bluuebunny/crossref_metadata_2025 huggingface dataset:
Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells
Authors: Naderali Elahe , Valipour Behnaz , Khaki Amir Afshin , Soleymani Rad Jafar , Alihemmati Alireza , Rahmati Mohammad , Nozad Charoudeh Hojjatollah
Published: August 2019

Purpose: The PI3K/Akt signaling pathway regulates cell growth, proliferation and viability in hematopoietic cells. This pathway always dysregulates in acute lymphoblastic leukemia (ALL). PTEN and P53 are tumor suppressor genes correlated with PI3K/Akt signaling pathway, and both have a tight link in regulation of cell proliferation and cell death. In this study, we investigated the effects of dual targeting of PI3K/Akt pathway by combined inhibition with nvp-BKM-120 (PI3K inhibitor) and MK-2206 (Akt inhibitor) in relation with PTEN and P53 on apoptosis and proliferation of leukemia cells. Methods: Both T and B ALL cell lines were treated with both inhibitors alone or in combination with each other, and induction of apoptosis and inhibition of proliferation were evaluated by flow cytometry. Expression levels of PTEN as well as p53 mRNA and protein were measured by real-time qRT-PCR and western blot, respectively. Results: We indicated that both inhibitors (BKM-120 and MK-2206) decreased cell viability and increased cytotoxicity in leukemia cells. Reduction in Akt phosphorylation increased PTEN and p53 mRNA and p53 protein level (in PTEN positive versus PTEN negative cell lines). Additionally, both inhibitors, particularly in combination with each other, increased apoptosis (evaluated with Annexin V and caspase 3) and reduced proliferation (Ki67 expression) in leukemia cells. However, administration of IL7 downregulated PTEN and P53 mRNA expression and rescued cancer cells following inhibition of BKM-120 and MK-2206. Conclusion: This investigation suggested that inhibition of Akt and PI3K could be helpful in leukemia treatment.
The Effects of Thymoquinone on Viability, and Anti-apoptotic Factors (BCL-XL, BCL-2, MCL-1) in Prostate Cancer (PC3) Cells: An In Vitro and Computer-Simulated Environment Study
Authors: Saffari_Chaleshtori Javad , Heidari-Sureshjani Ehsan , Moradi Fahimeh , Heidarian Esfandiar
Published: August 2019

Purpose: Since active plant ingredients can induce apoptosis in many tumors, in this study we evaluate the apoptotic effects of thymoquinone (TQ) on PC3 cells. Also, we predicted the interaction of TQ with BCL-XL, BCL-2, and MCL-1anti-apoptotic factors by computer-simulated environment. Methods: PC3 cells were treated with different concentrations of TQ (0- 80 µM) and IC50 was determined using 3-(4, 5-dimethylthiaztol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Apoptotic and cytotoxicity effects of TQ were analyzed using flowcytometry and comet assay, respectively. Changes in energy and the molecular interactions of TQ with BCL-XL, BCL-2 and MCL-1 anti-apoptotic factors were investigated using simulation. Results: IC50 value was 40 µM. TQ led to the destruction of the genome of PC3 cells and inducing apoptosis. Molecular dynamics (MD) revealed that the root mean-square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), and the number of hydrogen and hydrophobic bonds between TQ and residues of BCL-2, BCL-XL and MCL-1were significantly (P<0.001) changed. TQ makes a more stable and stronger connection with BCL-XL compared to BCL-2 and MCL-1 and inhibits BCL-XL non-competitively. Conclusion: Our results demonstrated that TQ not only led to apoptosis, at least partly, due to reduction in the Coil, Turn, and Bend structure of BCL-XL but also caused a decrease in the Rg and RMSD value of BCL-XL, MCL-1, and BCL-2.
Evaluating the Differential Effects of Valproic Acid on Wharton’s Jelly Mesenchymal Stem Cells
Authors: Salami Homa , Mowal Seyed Javad , Moukhah Rasoul , Hajebrahimi Zahra , Hosseini Seyed Abdolhakim , Edalat Houri
Published: August 2019

Purpose: The histone deacetylases (HDAC) inhibitor, valproic acid (VPA), is a common antiepileptic drug and is attractive for its broad range of therapeutic effects on many diseases. It has been employed as an inducer of pluripotency in some cultured cells. Conversely, VPA has also been employed as an inducer of in vitro differentiation in many other cells. Therefore, we employed WJMSCs as a cellular target to evaluate the differential effects of of VPA on potency state and differentiation level of Wharton’s Jelly mesenchymal stem cells (WJMSCs) in various concentrations and different culture mediums. Methods: The isolated WJMSCs were cultured in DMEM (MSC medium). According to previous protocols, WJMSCs were treated with 0, 0.5 and 1 mM VPA in MSC or embryonic stem cell (ESC) medium and 2 mM VPA in neural differentiation medium. Real-time polymerase chain reaction (PCR) and western blot analysis were performed for evaluating the expression of pluripotency markers. MTT and caspase assays were also performed on VPA-treated cells. Results: The expression of pluripotency markers and the viability of the WJMSCs – determined by MTT assay – were significantly increased after 0.5 mM VPA treatment in ESC medium. A 2 mM VPA treatment in neural differentiation medium significantly diminished the expression of pluripotency markers and the viability of WJMSCs. Conclusion: According to our results, both VPA concentration and the medium context can influence VPA effects on WJMSCs. The differential effects of VPA on WJMSCs can reflect its wide range of effects in the treatment of various diseases.
Modification of AC Thermal Properties to Mitigate UHI Effects
Authors: Papagiannakis A. T. , Kaphle R.
Published: August 2019

An analysis of the asphalt concrete (AC) pavement material properties that affect surface temperatures is presented. These properties affect the contribution to the urban heat island effects. Its goal is to analyze the effect of various alternative aggregate materials, such as limestone, silica, polymer, glass, and graphite, on AC pavement surface temperatures under various environmental conditions. Pavement surface temperatures were analyzed for two extreme weather locations in the United States, namely South Texas and Northern Minnesota. Long-Term Pavement Performance weather data over a year-long period were analyzed for each location using the computer model Temperature Estimate Model for Pavement Structures. The average and range of pavement temperatures were compared at a depth of 0.01 m. It was concluded that the higher the coefficient of thermal conductivity, heat capacity, and albedo of the pavement surface layer, the lower the average and maximum surface temperatures are during the summer months. Graphite was shown as a promising limestone aggregate substitute producing significant reductions in AC surface temperatures. It reduced the peak daily surface temperatures by between 3.5°C and 5°C. On the other hand, the modified AC mixtures showed mechanical properties not quite at par with those of conventional ACs.
Detection of Porcine DNA in Processed Beef Products Using Real Time – Polymerase Chain Reaction
Authors: Septiani Triayu
Published: August 2019

Meat is one of food materials which has protein source and mostlyconsumed by non-vegetarian. Consuming halal food is an obligation for every Muslim. Meat processed products usually contaminated by pork. One of technique that is often chosen as an authentication process for proofing halalness of the product is PCR technique, one of PCR technique which most commonly used is RT-PCR. RT-PCR technique was chosen as identification method because it has high accuration for detection of porcine DNA in fresh meat and processed products. RT-PCR is the amplification technique in the specific regions that are restricted by two oligonucleotide with the help of polymerase enzymes. Annealing is the first process of RT-PCR analysis who was primary attachment to the DNA template that determines the specificity and amount of DNA produced. In this study, extraction kit and detection kit were used for analysis Porcine DNA in meatballs. The results obtained from this study were from whole DNA samples, which had DNA purity ranging from 1.82 to 1.93. From the all samples three of them containing porcine DNA. The positive samples shown from amplification curves who was specifically formed when probes reacts with porcine gene.
Caregivers’ strategies for eliciting storytelling from toddlers in Japanese caregiver–child picture book reading activities
Authors: Takada Akira , Kawashima Michie
Published: August 2019

Although storytelling is a central practice in everyday interaction, it is not an easy task for young children, because it requires extended turns-at-talk. To tell a story successfully, a child requires considerable support from the recipient. In this article, we examine how storytelling is facilitated in Japanese caregiver–child interactions, focusing on the strategies employed by caregivers to elicit storytelling from 2- to 3-year-old children during picture book reading activities. Our analysis indicates that caregivers employ various multimodal strategies in encouraging children to launch, develop, and end a story, and that these strategies are themselves effectively implemented through the application of several grammatical features, conventional expressions, and formulaic words. Hence, storytelling functions as a valuable device in orchestrating attention, affect, and morality in caregiver–child interactions.
Scaffolding storytelling and participation with a bilingual child in a culturally and linguistically diverse preschool in Australia
Authors: Theobald Maryanne
Published: August 2019

Children frequently share stories as they play. Oral storytelling brings forth matters to do with language competence, and thus may present challenges for those with varying linguistic ability or those who are have a first language other than the dominant language of the setting. This article reports on a study of children’s playground interaction in a culturally and linguistically diverse preschool in Brisbane, Australia. An extended sequence of interaction is showcased in which one bilingual child (aged four years), speaking in his second language, takes up the role of storyteller in a designated ‘storytelling chair’. Sequential analyses using conversation analysis show how scaffolding is collaboratively achieved through a teacher’s responsiveness and the children’s demonstrated competence as storyteller and story recipients. By focusing on the interactional contributions of the members rather than individuals’ linguistic development, findings offer understandings about the co-productive and interactive communicative resources required for scaffolding storytelling.
Referring to past actions in caregiver–child interaction in Japanese
Authors: Takagi Tomoyo
Published: August 2019

In naturally occurring everyday caregiver–child interaction, a major part of what is hearable as storytelling or an incipient form of it is talk about participants’ (mostly children’s) past experiences. Adopting a conversation-analytic approach, this study attempts to show how explicit references to children’s past actions formulated in the form of [(X) did (Y)], where X is the young child interacting with the caregiver, can engender opportunities for participants to develop telling activities. Through the detailed analysis of talk and embodied features of telling sequences in each case, the analysis will reveal how the [(X) did (Y)]-format utterance is utilized for co-constructing the telling, and what social and interactional consequences are accomplished through the telling occasioned by such reference.
State of the art in vulvar cancer imaging
Authors: Serrado Maria Ana , Horta Mariana , Cunha Teresa Margarida
Published: August 2019

Abstract Vulvar carcinoma is an uncommon tumor that predominantly affects postmenopausal women. Currently, there is no screening procedure for vulvar carcinoma; in most cases, it is diagnosed only when symptoms appear. The most widely used staging system is that developed by the International Federation of Gynecology and Obstetrics. Lymph node status is the most important prognostic factor. We searched the PubMed/Medline database to identify relevant English-language articles on vulvar cancer, with a special focus on its imaging evaluation. Magnetic resonance imaging is useful for local and nodal staging, as well as facilitating the planning of surgical interventions and radiotherapy. Computed tomography or positron-emission tomography/computed tomography can play an important role in nodal and distant disease assessment, whereas ultrasound is often used for image-guided biopsies. Imaging is pivotal for staging and treatment planning in vulvar carcinoma.
Fetal posterior fossa malformations: review of the current knowledge
Authors: Milani Hérbene Jose Figuinha , Barreto Enoch Quindere de Sá , Ximenes Renato Luis da Silveira , Baldo Carlos Alberto Raimundo , Araujo Júnior Edward , Moron Antonio Fernandes
Published: August 2019

Abstract Ultrasound diagnosis of posterior fossa malformations in the prenatal period is a challenge, having major implications for the counseling and follow-up of pregnant women. The purpose of this study was to review aspects of the ultrasound evaluation of the fetal posterior fossa, as well as to describe the most relevant ultrasound findings of the main posterior fossa malformations that can affect the fetus in the prenatal period.
The many faces of pseudomyxoma peritonei: a radiological review based on 30 cases
Authors: Fonseca Cássia , Carvalho Saulo , Cunha Teresa Margarida , Gil Rui Tiago , Abecasis Nuno
Published: August 2019

Abstract Objective: To determine the most common imaging features of pseudomyxoma peritonei (PMP), as well as the histologic subtypes of the primary tumors. Materials and Methods: We reviewed 30 cases of women with pathologically confirmed PMP. Only computed tomography scans were available. All cases were retrospectively studied by four radiologists, working independently. We identified the most common imaging findings, the predominant primary site of the disease, and the growth pattern. The most common sites of recurrence were also analyzed. Results: The most common computed tomography finding was peritoneal/omental nodules (including “omental caking”), followed by visceral scalloping and non-mucinous ascites. The most common site of the primary tumor was the appendix (in 63.3%), followed by the ovaries (in 16.6%), and 16.6% of the tumors were of undetermined origin. There was one case of synchronous appendiceal and ovarian tumors. Low-grade mucinous neoplasm was the most common histologic subtype, accounting for 84.2% of the appendiceal tumors and 40% of the ovarian tumors. Conclusion: Although PMP is a relatively rare entity, radiologists must be aware of its possible imaging findings, common locations, and possible patterns of recurrence. The origin of the primary tumor should also be investigated. Future studies are needed in order to determine which preoperative imaging findings predict surgical outcomes and to characterize the main findings of radiological recurrence.
USA’s trade policy in the context of global crisis and the decline of North American hegemony
Authors: Guillén Arturo
Published: August 2019

ABSTRACT The global crisis of 2007 reinforced the deflationary tendencies, as well as the withdrawal of the central countries inwards. After the Great Recession 2008-2009, most economies have experienced semi-stagnation and deglobalization processes. The crisis accelerated the decline of the hegemony of the United States. While they retain an overwhelming military advantage and maintain financial hegemony, they have lost ground in production, in international trade and in direct foreign investment. Trump’s trade policy will accelerate deglobalization. And while its tax cut has had a short-term positive effect on growth, it will be difficult to overcome “secular stagnation”.
Economic globalization in the global post-crisis of 2008: limits and deadlocks
Authors: Manzi Rafael Henrique Dias
Published: August 2019

ABSTRACT Economic globalization has entered a new phase of relative stagnation and cooling since the beginning of the global crisis of 2008. The main objective of this article is to examine the dynamics that explain the stagnation of the economic globalization process from the beginning of the global crisis of 2008. The initial results indicate that the process of stagnation of global forces is not only related to a scenario of lower economic growth of the global economy after 2008, but also reflects mainly political dynamics within national states and the international system itself that have a direct impact on the phenomenon of economic globalization.
Supplanting resistance of the Mi gene by root-knot nematode in industrial tomato in the Cerrado in Goiás State of Brazil
Authors: Silva Rodrigo Vieira da , Lima Brenda Ventura de , Peixoto Fabricio Rodrigues , Gondim João Pedro Elias , Miranda Bruno Eduardo Cardoso de
Published: August 2019

ABSTRACT: Problems with root-knot nematodes, caused by genus Meloidogyne, can be controlled through the introduction of resistance genes in commercial varieties of tomatoes. However, plants of the hybrid ‘Heinz 9992’ for industrial processing, carrying the Mi gene, were reported with their roots severely infected in experimental cultivation in Goiás State of Brazil with symptoms typical of galls caused by Meloidogyne spp. After dissecting the galls present in the root samples, the females of the nematodes were removed and afterwards, performed the analysis of the perineal pattern and the biochemical characterization by electrophoresis of isoenzymes, besides the pathogenicity test. The pathogen analyzed was identified as Meloidogyne incognita. The pathogenicity test confirmed the supplanting resistance of the tomato hybrid with the Mi gene by this virulent population of M. incognita.
Fibroadnexal hamartoma in the dog: retrospective epidemiological and histopathological study of 102 cases
Authors: Loures Fabrícia Hallack , Conceição Lissandro Gonçalves , Acha Lívia Maria Rosa
Published: August 2019

ABSTRACT: Fibroadnexal hamartoma (FH), also called focal adnexal dysplasia, is the most common hamartomatous lesion in dogs. There are few retrospective studies about FH in dogs, which did not describe histopathological findings in detail. The main objective was to conduct a retrospective study and to describe the epidemiological and histopathological characteristics of a series of 102 FH cases in dogs. Descriptive statistics and Odds Ratio were used to analyze the data. The lesions were exophytic and measured on average 2.5 cm in diameter. The anatomic sites most affected were the limbs and digital region. The animals were on average 7 years of age and both sexes were equally affected. Doberman (OR: 4.15; P=0.0069) and Schnauzer (OR: 2.50; P=0.049) showed a higher risk for FH. Recurrence was not observed in any case. Four histopathological FH subtypes were identified: follicle-sebaceous (73.53%), sebaceous (16.66%), follicular (8.82%) and sebaceous-apocrine (0.98%). Diffuse and perianexial fibroplasia and inflammation were frequently seen. Chronic inflammation and mature adipocytes were seen in 71.6% and 7.8% of the cases, respectively.
Antimicrobial activity of enterocin obtained from Enterococcus durans on Shiga-like toxin-producing Escherichia coli
Authors: Tosoni Natara Favaro , Perini Hugo Felix , Terra Márcia Regina , Katsuda Marly Sayuri , Furlaneto Márcia Cristina , Maia Luciana Furlaneto
Published: August 2019

ABSTRACT: Shiga-like toxin-producing Escherichia coli (STEC) is an important source of food contamination that presents risks to human health. Several industrial food processes eliminate this microorganism; however, these processes can alter the characteristics of the product. Alternative methods of preservation have been identified as an option to control these foodborne pathogens. The purpose of this study was to evaluate the action of bacteriocins produced by Enterococcus durans MF5 in STEC cells. Cell-free supernatant (CFS) containing enterocins from the MF5 isolate was tested over different time points (6, 18, and 24 h). Enterocins present in the crude CFS showed inhibition against STEC at all time points. In the investigation of cell integrity, using propidium iodide and fluorescence microscopy, considerable cell death was observed within 6 h of the cells being in contact with the enterocins, which was also observed at the 18 and 24 h time points. These results showed that the enterocins produced by the MF5 isolate have potential use in the control of STEC.
Mudanças climáticas, ciência e sociedade
Authors: Fleury Lorena Cândido , Miguel Jean Carlos Hochsprung , Taddei Renzo
Published: August 2019

Resumo Este texto propõe uma breve apresentação dos estudos em sociologia das mudanças climáticas, sugerindo uma síntese do surgimento dessa área de pesquisa, suas principais contribuições para o debate e, em especial, destacando suas inter-relações com o campo dos Estudos Sociais em Ciência e Tecnologia (ESCT). Desse modo, pretende contextualizar o dossiê Mudanças climáticas, ciência e sociedade, que compõe esta edição de Sociologias. Este dossiê articula textos de autores nacionais e internacionais que demonstram o quanto o tema das mudanças climáticas vem sendo enfrentado nas diferentes esferas de ação política e tem-se institucionalizado, demonstrando ser um objeto privilegiado para a análise do reordenamento contínuo das relações sociais por meio da interface entre conhecimento científico, políticas públicas e materialidades. Portanto, de forma pioneira no debate nacional, o dossiê sumariza uma contribuição do enfoque sociológico ao tema que se tem demonstrado cada vez mais premente: os efeitos das mudanças climáticas na vida social contemporânea. Os artigos aqui reunidos discutem as batalhas travadas sobre o assunto dentro das distintas arenas políticas, e nos permitem constatar como a questão das mudanças climáticas tem poder de agenciamento de transformações políticas em diversas escalas e territórios. Assim, os textos apresentados documentam como a coexistência de paradigmas, associada a transformações no âmbito das ciências da terra, constitui-se em oportunidade ímpar de elaboração analítica e teórica para a sociologia e os ESCT.
Intra-annual variation in rainfall and it’s influence of the adult’s Cyprideis spp (Ostracoda, Crustacea) on a eutrophic estuary (Guanabara Bay, Rio de Janeiro, Brazil).
Authors: Pessoa L. A. , Paiva P. C. , Paranhos R. , Freitas M. A. V. , Echeverría C. A.
Published: August 2019

Abstract Spatial and temporal distribution of two species of adult´s ostracods (Cyprideis sp. and Cyprideis salebrosa) were studied as a function of the rainfall patterns in the Guanabara Bay, Rio de Janeiro, Brazil. Samples were taken in ten stations, along six surveys representing three periods (Dry, Early and Late Rainy) for two years. Stations were nested in four areas (Outer, Central, EPA Guapimirim and Impacted). The bottom water (temperature, salinity, dissolved oxygen and oxygen saturation) were measured in each area to characterize the influence of seasonal variations by rainfall. Cyprideis sp. and Cyprideis salebrosa showed patterns distribution to seasonality/surveys (p = 0,002 and p <0,001, respectly). The spatial distribution of Cyprideis sp was significantly different areas studied (p <0.001) indicated well defined areas and distribution in along of the surveys. However, C. salebrosa showed homogeneous distribution in along of the areas within of each survey (p <0.001). Redundancy Analysis (RDA) for the two years evidenced environment preference of the Cyprideis sp. for areas with marine conditions (high influence for channel central) and C. salebrosa for brackish water (high influence of the rivers). This observation reinforces of the existence of areas created by the seasonality of pluviometric regime, a possible dispersion of the adult’s ostracods and possibility the use with bioindicators.
Survey of fish species from the Lower Roosevelt River, Southwestern Amazon basin
Authors: Anjos Marcelo Rodrigues dos , Machado Nadja Gomes , Pedersoli Mizael Andrade , Pedersoli Nátia Regina Braga , Barros Bruno Stefany , Lourenço Igor Hister , Barreiros João Pedro
Published: August 2019

Abstract: This study presents an inventory of the ichthyofauna of the lower Roosevelt River sub-basin and its associated tributaries. Fish sampling with fishing nets and measurements of environmental parameters of water occurred in November/2012 (rising water), February/2013 (flooding), May/2013 (falling water) and August/2013 (drought). Depth mean was 8.86 m, water transparency was 0.6 m, conductivity was 22.7 µS.cm-1, pH was 6.59, dissolved oxygen was 7.63 mg.l-1 and temperature was 28°C. The total estimated capture area was 68,829.6 m2 during 2,880 hours. The catch per unit Effort (CPUE) was 0.37 individuals m-2.day-1. Species were spatially aggregated in all sampling points and river water levels. A total of 5,183 individuals distributed in 7 orders, 29 families, 104 genders and 188 species were sampled in this survey. The diversity index was 4.121 and equitability index was 0.789. The Characiforms order was the most abundant with 106 species, followed by Siluriforms with 63 species and Cichliforms with 23 species. The most abundant species was Serrasalmus rhombeus (Linnaeus, 1766) with 327 individuals (5.9%), followed by Chalceus epakros (Cope, 1870) with 309 individuals (5.6%) and Acestrorhynchus microlepis (Schomburgk, 1841) with 250 individuals (4.5%). Trophicity was characterized by omnivorous (28.6%), piscivorous (14.3%), carnivorous (13.8%) and detritivorous (12.8%). According to IBAMA's regulation, 29.25% of captured species presents ornamental potential.
FAZENDO E DESFAZENDO GÊNERO NA POLÍTICA: UMA HISTÓRIA DE VIDA
Authors: Chaves Adller Moreira , Souza Eloisio Moulin de
Published: August 2019

RESUMO Este artigo tem como objetivo analisar como o gênero é feito e desfeito dentro da política institucional. Para tanto, investigou-se a história de vida de uma vereadora, sendo que a produção dos dados foi feita por meio de 13 encontros. Nestes, ocorreram as entrevistas que permitiram entender a relação entre a história de vida da participante com o fazer e desfazer o gênero no contexto da política partidária institucional. Os dados produzidos foram analisados por meio de análise de discurso, onde constatou-se a importância e a influência da família, da escola e do trabalho na constituição das performances e performatividades de gênero no legislativo municipal. As histórias relatadas pela vereadora mostram que as relações de poder no contexto em que está inserida manifestam as performatividades e regulam suas possíveis performances no espaço legislativo. Dessa forma, constatou-se que o fazer masculinidade é utilizado pela participante como estratégia para a sua sobrevivência neste espaço.
UM ESTUDO SOBRE SENTIDOS DA MEDIDA SOCIOEDUCATIVA DE INTERNAÇÃO NA VIDA DE ADOLESCENTES INSTITUCIONALIZADOS
Authors: Oliveira Thaíssa Fernanda Kratochwill , Miranda Lilian
Published: August 2019

RESUMO O presente artigo é o desdobramento de uma pesquisa mais ampla que investigou a função da medida socioeducativa de internação na vida de adolescentes que cumpriam tal medida em uma instituição do Rio de Janeiro e discute os sentidos atribuídos por estes sujeitos à determinação judicial e à experiência do cumprimento da medida. Adotando a perspectiva hermenêutica em pesquisa qualitativa e o método clínico-qualitativo, foram realizadas entrevistas abertas com oito adolescentes e utilizada a observação participante. O estudo de suas histórias de vida permitiu a observação de aspectos de suas construções subjetivas sobre sua relação com a criminalidade e com o cumprimento da medida socioeducativa. Em relação ao sistema socioeducativo, os relatos revelaram aspectos da rotina no dia-a-dia e da assistência prestada aos adolescentes na instituição, bem como suas consequências em seu processo socioeducativo, sendo possível apontar possíveis estratégias de aperfeiçoamento do potencial socioeducativo das unidades do sistema.
Haciendo-lugar vía huellas y apegos: las personas migrantes africanas y sus experiencias de movilidad, inmovilidad e inserción local en América Latina. Introducción al dossier temático REMHU 56
Authors: Winters Nanneke , Reiffen Franziska
Published: August 2019

Resumen Este artículo introductorio al dossier temático traza los conocimientos y estudios existentes sobre la actual migración africana subsahariana hacia y por América Latina, y propone una perspectiva del haciendo-lugar para su análisis. Tal enfoque analítico permite incluir y vincular las experiencias y prácticas de las personas migrantes con una mirada más estructural que tiene en cuenta regímenes de movilidad y la industria de la migración. Más allá de una victimización o esencialización de las personas migrantes africanas, así se puede llegar a una mejor comprensión de sus compromisos de corta o larga duración con los lugares en los cuales habitan o que atraviesan en sus trayectorias; compromisos que afectan y se desarrollan tanto a un nivel material como social y emocional.
A Loja de Mohamed. Espaços transnacionais, práticas muçulmanas e relações de gênero entre migrantes senegaleses numa pequena cidade do Rio Grande do Sul
Authors: Mejía Margarita Rosa Gaviria , Scapin Marcele
Published: August 2019

Resumo Este artigo aborda experiências migratórias de senegaleses e as conexões transnacionais que dão suporte a esse fluxo migratório, fundamentado em princípios religiosos muçulmanos da confraria murid. As reflexões apoiam-se numa pesquisa etnográfica realizada em Lajeado, Rio Grande do Sul. O eixo de análise são as trajetórias de vida de migrantes das quais nos aproximamos na Loja de Mohamed, qualificada como espaço transnacional, com ênfase nas relações de gênero instituídas com base no muridismo. O artigo contribui para pensar relações de gênero e dar visibilidade aos migrantes senegaleses em Lajeado, contingente migratório que não aparece no registro da distribuição de migrantes senegaleses no Rio Grande do Sul.
Más allá de la vigilancia y el control. Políticas de regularización y migración boliviana en la ciudad de La Plata, Argentina
Authors: Rodrigo Federico
Published: August 2019

Resumen El artículo aborda el modo en el que en torno a la implementación de programas de documentación para migrantes y a la posibilidad del acceso de las personas a los “papeles” se constituyen procesos políticos que transforman el lugar de los/as arribados/as en la sociedad de destino, focalizando en el caso de la migración boliviana a la ciudad de La Plata. De esta manera, indagamos en una dinámica en la que agencias consulares e instituciones sociales, sindicales y partidarias locales situaron a los/as migrantes como actores relevantes en el marco de sus objetivos y fueron parte del desarrollo de procesos de movilización y elaboración de demandas novedosas. Se busca sostener, entonces, dos argumentos: en primer lugar que los documentos de identidad -y las políticas destinadas a facilitar su tramitación- pueden ser objetos con una productividad política mucho más compleja que la restringida a la vigilancia y el control. Y, en sintonía, frente a los discursos que señalan que los programas de regularización operan como una forma de continuidad de lógicas securitarias, apostamos a demostrar que junto con la Ley 25.871 formaron parte inescindible de una dinámica de posicionamiento ciudadano de las personas bolivianas que impacta en diferentes aspectos de sus vidas.
Proposta de um construto para gestão da informação no ciclo de vida dos agentes
Authors: Silva Sergio Evangelista , Ribeiro Filipe Nunes , Garcia Joao Alexandre Borges , Amorim Vicente José Peixoto de , Camarda Rafael Ferreira
Published: August 2019

Resumo Atualmente as infromações geradas por um agente (ex. uma pessoa; um automóvel; uma obra pública, etc.) ao longo do seu ciclo de vida encontram-se espalhadas por diferentes sistemas de informação (SIs) de diferentes organizações. Por exemplo, um cidadão ao longo de sua vida gera informações nos mais variados tipos de organização (ex. hospitais, escolas, empresas, repartições públicas, etc.). Todavia, estas informações contidas nos SIs destas organizações não podem ser livremente acessadas por este cidadão. Contudo, frente ao atual desenvolvimento tecnológico é possível desenvolver SIs capazes de centralizar em um único respositório as informações geradas por um agente ao longo do seu ciclo de vida, construção essa ainda pouco observada em nossa sociedade. Em face desta oportunidade de pesquisa neste artigo é proposto um construto para gestão da informação no ciclo de vida dos agentes (GICVA). Tendo em vista seu caráter aplicado é utilizado o método Design Science Research (DSR). Em seguida, este construto é demonstrado por meio de um SI para gestão de informações de pessoas em dois contextos. Da perspectiva conceitual este artigo apresenta um novo construto que permitirá desenvolver SIs sob um novo paradigma. Da perspectiva da aplicação, SIs baseados nos princípios da GICVA poderão ser implementados para gerenciar informações de diferentes tipos de agentes, tais como pessoas, automóveis, imóveis, projetos, dentre outros, podendo trazer grandes benefícios para a sociedade.
Níveis de pressão sonora em salas de aula de uma Universidade e seus efeitos em alunos e professores
Authors: Dias Fernanda Abalen Martins , Santos Bárbara Alves dos , Mariano Hully Cecília
Published: August 2019

RESUMO Objetivo Mensurar os níveis de pressão sonora em salas de aula de uma Universidade, bem como verificar a autopercepção do ruído e sua influência nas atividades desempenhadas por alunos e professores universitários. Método Trata-se de um estudo realizado em dez salas de aula do Instituto de Ciências Biológicas e da Saúde da Pontifícia Universidade Católica de Minas Gerais. Participaram do estudo 279 alunos e 20 professores. Alunos e professores responderam a um questionário destinado ao levantamento de informações sobre a autopercepção do ruído nas salas de aula, seus impactos nas atividades acadêmicas e presença de sintomas associados à exposição ao ruído. Foi realizada também medição dos níveis de pressão sonora nas salas de aula, em pontos selecionados de acordo com o recomendado pela literatura e conforme consta na legislação. Resultados As salas de aula do turno da manhã apresentaram o maior nível de ruído. O primeiro andar apresenta maior nível de ruído mensurado, sendo classificado como o andar mais ruidoso. O ruído é percebido tanto por alunos quanto pelos professores como fator interferente nas atividades desempenhadas dentro das salas de aula, entretanto professores apresentam maior percepção da interferência do ruído em suas atividades que os alunos. Não foi observada ocorrência significativa de sintomas associados à exposição ao ruído. Conclusão O ruído está presente em todas as salas de aula com valores superiores ao preconizado pela legislação nacional. Este ruído é percebido por alunos e professores e interfere negativamente nas atividades de ensino-aprendizagem.
Desenvolvimento e aplicação de um game sobre saúde e higiene vocal em adultos
Authors: Roza Ana Paula , Gielow Ingrid , Vaiano Thays , Behlau Mara
Published: August 2019

RESUMO Objetivo Desenvolver um game sobre saúde e higiene vocal (VoxPedia) e aplicá-lo em adultos, para investigar o conhecimento em cuidados vocais e compreender a autoavaliação vocal dos respondentes. Método Participaram 293 adultos, 204 mulheres e 129 profissionais da voz, convidados através de mídias digitais. Os participantes responderam: 1) Termo de Consentimento Livre e Esclarecido (TCLE); 2) Dados de Identificação; 3) Protocolo do Índice de Desvantagem Vocal (IDV-10); 4) Questionário de Saúde e Higiene Vocal (QSHV); 5) Aplicação do quiz VoxPedia. Resultados O VoxPedia foi desenvolvido com questões simples e com dinâmica que permitiu aos participantes conhecerem seu desempenho em tempo real. Os dados adquiridos através do quiz mostram que os profissionais da voz relataram menos desvantagem vocal e acertaram mais itens no QSHV e questões do VoxPedia. Profissionais da voz ou não, os participantes que erraram a natureza do impacto dos aspectos de saúde no QSHV referiram maior desvantagem vocal no IDV-10. Contudo, apesar da desvantagem autorreferida, a maioria não relata problemas de voz. Em contrapartida, quando o respondente relatou problemas de voz, nem sempre houve desvantagem percebida ou busca por terapia vocal. Conclusão O VoxPedia apresentou alguns conceitos de saúde e higiene vocal aos participantes. Além disso, possibilitou o estudo das relações entre conhecimento em cuidados vocais e autoavaliação vocal. Os dados sugerem que os indivíduos com mais conhecimento em cuidados vocais têm melhor autoavaliação de voz; participantes com pior autoavaliação vocal não percebem problemas de voz; e aqueles que percebem problemas vocais não necessariamente procuram cuidados profissionais.
Auditory training in autism spectrum disorder: a case report
Authors: Ferreira Laís , D’Agostini Ayra Renata , Pichini Fernanda dos Santos , Pazini Eduarda , Rechia Inaê Costa , Biaggio Eliara Pinto Vieira
Published: August 2019

ABSTRACT This study aimed to measure the effects of a Computer-based Auditory Training Program (CBATP) on an adolescent diagnosed with Autism Spectrum Disorder (ASD) and Central Auditory Processing Disorder (CAPD). This is the case report of a male, 14-year-old adolescent diagnosed with ASD. The individual was submitted to basic audiological evaluation, central auditory processing assessment and hearing electrophysiology (EP), pre- and post-therapeutic intervention. Central auditory processing (CAP) was assessed by means of the following instruments: Time-compressed Speech Test (TCST), Random Gap Detection Test (RGDT), Staggered Spondaic Word Test (SSWT), Frequency (Pitch) Pattern Sequence Test (FPST), and Duration Pattern Test (DPT). The P300 component of the Event-related Potential (ERP) was used in the hearing EP. Pre-intervention assessment of CAP showed changes in the auditory skills of closure, figure-ground and temporal ordering, but normal temporal resolution ability. Post-intervention evaluation of CAP showed improvement in all previously mentioned auditory skills, except for the figure-ground ability, which remained unchanged. Regarding the findings of the hearing EP, a decrease in the latency of the P300 component was observed pre- and post-intervention. This study demonstrated that the use of a CBATP resulted in improvement in the hearing abilities assessed in an adolescent diagnosed with ASD.
Evidence of orofacial myofunctional therapy patients with asthma and rhinitis: a systematic review
Authors: Araújo Brenda Carla Lima , Simões Silvia de Magalhães , Moreira Marcela Gama Santana , Mendes Amanda Louize Félix , Martins-Filho Paulo Ricardo Saquete
Published: August 2019

ABSTRACT Purpose to evaluate the efficacy of orofacial myofunctional therapy in improving orofacial function and nasal breathing in patients with asthma and rhinitis and, consequently, achieve clinical control of these conditions. Research strategies We used the elements of the PICOT method (study population, intervention, comparison, outcomes and type of studies) to define the eligibility criteria: (1) Population: patients with asthma and rhinitis; (2) Intervention: orofacial myofunctional therapy to improve chewing, swallowing, and breathing; (3) Comparison: control group without orofacial myofunctional therapy; (4) Predefined outcomes: clinical control of asthma and improvement of orofacial functions and nasal breathing; (5) Study type: clinical trials. The data were collected from PubMed, SCOPUS, Web of Science, Science Direct, LILACS, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), OATD, and Open Thesis, in November 2018. Selection criteria Randomized controlled trials published in full-text versions without language restriction, no filter was used. Data analysis Demographic characteristics of study participants, specific diagnosis of asthma and control medication, type, duration, intensity and follow-up of orofacial myofunctional therapy, and outcome data. The risk of bias was assessed according to the Cochrane guidelines for clinical trials. Results One study met the eligibility criteria: although the study has shown an improvement of functional control and clinical scores of asthma, the evidence is very low. Conclusion There is no scientific evidence on the efficacy of orofacial myofunctional therapy in improving clinical control, orofacial function, and nasal breathing in patients with asthma and rhinitis.
Associação interna como forma de integração dos presídios às redes externas do tráfico: a percepção dos agentes territoriais da segurança pública no estado do Pará
Authors: Reis Netto Roberto Magno , Chagas Clay Anderson Nunes
Published: August 2019

Resumo Este artigo busca compreender a estratégia de estabelecimento e manutenção de redes ou relações entre os agentes sintagmáticos internos ao cárcere como forma de integração dos presídios às redes territoriais externas do tráfico de drogas, a partir da percepção de agentes territoriais da segurança pública no estado do Pará. Pautado em um método hermenêutico e dialético, e sob uma abordagem qualitativa e quantitativa, o presente estudo se valeu da técnica de coleta de dados por entrevistas direcionadas a agentes territoriais da segurança pública no estado do Pará, seguida de uma análise do conteúdo das falas. Essa análise dos dados confirmou a existência da estratégia considerada, bem como suas possíveis peculiaridades locais (relativas à influência das transferências e à inadvertida junção de presos no cárcere). Igualmente, restaram identificados aspectos práticos sobre o processo de cooptação de internos e a centralidade das lideranças, bem como elementos relativos à economia interna das facções da atividade do tráfico de drogas.
Following McWhinney’s footsteps: from family medicine to traditional and complementary medicine
Authors: Norman Armando Henrique , Tesser Charles Dalcanale
Published: August 2019

Family physicians have developed a holistic approach to patients’ care which can facilitate a mutual understanding of different Traditional and Complementary Medicine (T&CM) practices. This analytical paper considers three intertwined issues: (1) Ian McWhinney’s critique of biomedical abstractions (i.e., disease categories); (2) The similarity between the cosmology of family medicine’s organismic thinking and homeopathy’s vitalism as an example of T&CM; and (3) The gradient of explanatory models (EMs) to delineate the space within which T&CM can be applied to patients’ care. In primary health care predominates a blend of physiopathological and semiological EMs comprised of low to moderate risk patients. In this scenario, the introduction of T&CM practices can enhance family physicians’ therapeutic scope. Thus, the combination of gradient of EMs, primary health care attributes, and family physicians’ professionalism can provide the required safe environment for implementing T&CM services.
O governo das condutas e os riscos do risco na saúde
Authors: Carvalho Sergio Resende , Andrade Henrique Sater de , Oliveira Cathana Freitas de
Published: August 2019

Buscamos, a partir de uma perspectiva governamental, refletir sobre os modos que o conceito de risco vem operando na saúde e dialogar com práticas discursivas, como a Nova Saúde Pública e a Medicina da Vigilância. Entendemos que o risco não existe em si, mas constitui-se como uma tecnologia moral e política que fabrica modos de olhar e de calcular a realidade, governar condutas, normalizar o social e produzir subjetividades. Ao estimular uma vida saudável, seus efeitos podem contribuir para uma “governamentalidade neoliberal”, induzindo-nos a uma autovigilância ativa, construindo uma “cidadania econômica” e um ideal de “empresários de si mesmos” e criando redes de vigilância e normalização que reforcem modos submissos e pouco potentes de viver. Apesar desses “riscos do risco”, essas tecnologias defrontam-se continuamente com práticas de resistência e contracondutas que inventam outros possíveis para a saúde e a vida.
Repensando as políticas de Saúde no Brasil: Educação Permanente em Saúde centrada no encontro e no saber da experiência
Authors: Carvalho Monica Sampaio de , Merhy Emerson Elias , Sousa Maria Fátima de
Published: August 2019

Este artigo tem o objetivo de discutir a formação em Educação Permanente em Saúde (EPS), denominada "EPS em Movimento" e realizada em 2012 pelo Departamento de Gestão da Educação na Saúde (DEGES) da Secretaria de Gestão do Trabalho e da Educação na Saúde (SGTES) do Ministério da Saúde (MS) do Brasil, em parceria com instituições de ensino, trabalhadores e gestores do Sistema Único de Saúde (SUS), e que teve como aposta principal dar visibilidade às experiências de EPS, provenientes das afecções e dos encontros. Pretende-se cartografar e compreender essa experiência, seu caráter inovador e a conexão com os modos como as políticas de saúde para o SUS estão sendo formuladas e implementadas, incluindo a Política de Educação Permanente em Saúde instituída no Brasil desde 2003.
CERVICAL NEURENTERIC CYST: A CASE REPORT
Authors: D’HERBEMONT SOPHIE , MORALES-MARTÍNEZ ANDRÉS HUMBERTO , NAVARRO-CHÁVEZ IGNACIO PAVEL
Published: August 2019

ABSTRACT Objective Neurenteric cysts account for 0.7–1.3% of all spinal cord tumors. These rare lesions are composed of heterotopic endodermal tissue. Methods A 26-year-old woman with a 13-month history of severe cervicalgia and brachial paresthesia. Clinically she had mildbilateral brachial paresis (4/5), generalized hyperreflexia and a left Babinski Sign. Past medical history was significant for a cervical fistula closure when she was 1yearold. The superior somatosensory evoked potentials revealed medullary axonal damage with a left predominance. A cervical magnetic resonance imaging of the neck was performed showing a dorsal homogeneous cystic intradural extramedullary lesion with high signal intensity on T2. Computed tomography revealed a Klippel-Feil syndrome. Results A posterior laminectomy and surgical excision were performed without complications. Post-operative follow-up showed a complete recovery of arm strength. The histopathological report confirmed the preoperative diagnosis of neurenteric cyst. Most neurenteric cysts are located in the spine, mainly in a ventral position. A total of 95% of neurenteric cysts are found in the intradural/intramedullary compartment. Symptomatic neurenteric cysts typically appear in the second and third decades of life and are 1.5 to 3 times more common in men. In 50% of the cases, other vertebral malformations have also been reported. In this case, a congenital dorsal enteric cyst and a Klippel-Feil syndrome were observed. Conclusions The intraspinal neurenteric cysts are rare lesions that must be included in the differential diagnosis of a dorsal, intradural cystic structure. The diagnosis may be overlooked, especially in cases of chronic neck pain without neurological deficit. Level of evidence V; Expert Opinion.