bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatocyte growth factor and insulin-like growth factor-1 were used to repair bone-cartilage defects in bone marrow mesenchymal stem cells in a rabbit model of postmenopausal
Authors: Guan Jia-Qi , Zang Chuan-Bo , Li Jun-Cen , Chen Fei-Fan , Wang Ya-Hui , Zhou Guang-Dong , Liu Yu , Cao Yi-Lin
Published: June 2024

In postmenopausal osteoporosis (PMOP), an imbalance exists in the differentiation of bone marrow mesenchymal stem cells (BMSCs), with a decrease in osteogenic differentiation and an increase in adipogenic differentiation. This imbalance leads to bone marrow adiposity, bone loss, bone fragility, and a substantial rise in fracture risk. After a patient experiences an osteochondral defect due to trauma, it struggles to heal naturally, presenting a clinical challenge for treatment. Our study delved into the abnormal differentiation of BMSCs in PMOP by conducting transcriptome sequencing on BMSCs from a PMOP model (PMOP-BMSCs) and a healthy control model (Normal-BMSCs). We identified insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) genesas significantly low-expressed protein-coding genes during the osteogenic cartilage differentiation process of PMOP-BMSCs. Due to the downregulation of its expression, it leads to the deletion of the proteins it encodes IGF-1 and HGF. In order to verify the sequencing results, the feasibility of co-culture the above two growth factors with PMOP-BMSCs to repair osteochondral defects was discussed. The findings indicated that the inclusion of elements enhanced the DNA replication activity and extracellular matrix mineralization of PMOP-BMSCs. It also promoted the construction of tissue-engineered bone in vitro and the up- regulation of Runx2, BMP4, OCN, ACAN, collagen type Ⅰ, II, and Sox9 osteochondral differentiation markers. In the rabbit model of knee osteochondral injury with PMOP, the group treated with both growth factors and PMOP-BMSCs showed superior outcomes in repairing cartilage and subchondral bone defects compared to the other groups. We suggest that the addition of HGF and IGF-1 increases the expression of osteoblast and cartilage-related genes and proteins, promoting the proliferation and differentiation of osteochondrous bone in PMOP-BMSCs. These findings could offer a novel cell therapy strategy for treating postmenopausal osteoporosis, utilizing growth factors.
Revisión documental sobre depresión, ansiedad y estrés durante la crisis sanitaria en personal de salud
Authors: Fernández Alvarado Silvia , Flores Peláez Lesly Matilde , Ortiz Rafael Jhosibeth , Paima Trigozo Juliana Mayli , Puelles Chuquizuta Lusgardo Wian , Za Jhon Alexander
Published: June 2024

Durante la crisis por la pandemia en Latinoamérica la depresión, ansiedad y estrés tuvieron un impacto desfavorable en el estado mental del personal de salud. Objetivo: Determinar el estado del conocimiento con relación a la depresión, ansiedad y estrés en personal de salud durante la crisis sanitaria. Metodología: Investigación cualitativa de alcance descriptivo, se hizo una exploración de artículos científicos registrados en bases de datos utilizando los términos depresión, ansiedad, estrés, personal sanitario o de salud, Perú, México, y otros países de Latinoamérica. Resultados. Treinta y cinco artículos conformaron la muestra de estudio. Se evidenció una mayor frecuencia de publicaciones de alcance descriptivo. Los instrumentos de preferencia fueron los que incluyeron subescalas de depresión, ansiedad y estrés de manera conjunta. La afectación mental mostró depresión y ansiedad en nivel medio y estrés en nivel bajo. Los factores sexo femenino y estado civil soltero se asociaron a estos problemas emocionales. Conclusiones. Se evidenció un impacto negativo en el estado mental en cuanto a depresión y ansiedad en personal de salud, siendo las profesionales mujeres y solteros los más perjudicados; existe un vacío en publicaciones con variables de soporte que se relacionen de forma inversa con las tres disfunciones emocionales.
LA CRISIS DE LA RELIGIÓN EN LA SOCIEDAD POSMODERNA
Authors: García Inda Andrés
Published: June 2024

La gestión pública del elemento religioso en nuestra sociedad occidental posmoderna plantea hoy dudas importantes. Los poderes públicos están interfiriendo sobre la libertad religiosa de sus ciudadanos, ahogando cualquier voz discrepante en los medios de comunicación oficiales y vertiendo estereotipos tan confusos como interesados. Esta controvertida gestión pública del elemento religioso se enmarca dentro de un proceso de evidente crisis religiosa. Una crisis que, marcada por un hondo relativismo, no es ajena a un laicismo combativo ante toda visibilidad de elementos religiosos en el espacio público, propiciando un clima de evidente hostilidad. Una crisis que bebe de la insensibilidad de la secularización social extrema, que pretende reducir la creencia religiosa a una simple cuestión de opinión. Una crisis que, no obstante, también plantea apasionantes retos futuros. Más aún en una sociedad marcada por el pluralismo y la diversidad, y que parece abocada hacia una nueva convivencia entre personas de diferentes creencias. La libertad religiosa es una cuestión de dignidad humana. Pero también afecta a la cohesión social, a su organización e, incluso, a la identidad, tanto de las minorías como en clave nacional. Sobre todo esto, y muchas otras cosas más, trata este libro, cuyos capítulos han sido abordados por prestigiosos especialistas procedentes de la Filosofía del Derecho y del Derecho eclesiástico.
Protección de menores y discapacitados
Authors: Carrillo Pozo Luis , Herranz Ballesteros Mónica , Febles Pozo Nayiber , Moreno Blesa Lidia , Abad Arenas Encarnación , Agulló Agulló Diego , Cueto Santa Eugenia Elisabet , Vargas Gómez-Urrutia Marina , Gálvez Puebla Iracema , Pereira Pérez Joanna , Martínez Hernández Dariana
Published: June 2024

La obra trata temas actuales y de gran interés en relación con la protección de los menores, las personas discapacitadas, así como los adultos vulnerables, todos ellos integrantes de un núcleo de la población que necesita una atención y protección especial desde una perspectiva eminentemente jurídica como la que aportan los trabajos que conforman este libro. El enfoque internacional en los temas tratados es un elemento común en la mayoría de los trabajos que lo integran. Además, la incorporación de estudios desde el Derecho civil, la justicia juvenil o del Derecho comparado dotan al texto de una visión multidisciplinar muy valorada en estos tiempos y que enriquece el contenido de la obra colectiva. A lo anterior hay que sumar la proyección práctica que la mayor parte de los escritos han dado a los temas tratados y que, sin duda, será muy útil al operador jurídico que se dedique al tratamiento de los problemas expuestos en esta obra.
PRESENTE Y FUTURO DE LA NEGOCIACIÓN COLECTIVA
Authors: Martínez Moreno Carolina
Published: June 2024

Ha pasado ya un año y medio desde la promulgación y entrada en vigor del Real Decreto Ley 32/2021, de 28 de diciembre, de medidas urgentes para la reforma laboral, la garantía de la estabilidad en el empleo y la transformación del mercado de trabajo, un tiempo suficiente para poder hacer un balance mínimamente certero de sus efectos sobre el comportamiento del mercado de trabajo en nuestro país. Sin dejar de ser conscientes, como se destaca en el capítulo inicial, de que el complejo contexto socioeconómico y geopolítico en el que echaba a rodar este nuevo y ambicioso marco de ordenación del empleo y las relaciones laborales, caracterizado por una combinación realmente inusual de factores y variables, impide achacar a la reforma la íntegra responsabilidad de los aciertos o la falta de ellos. Esa es la principal finalidad del presente estudio, pero no la única, pues fiel a lo que indica el título de esta obra también tiene el propósito de ir algo más allá de convertirse en un comentario crítico más de la normativa reformada, e incorporar algunas propuestas con vistas a ese tan anunciado —y ahora de incierto pronóstico— Estatuto de los Trabajadores del siglo XXI. De ahí que junto a las materias centrales sobre las que recae la reforma de 2021, modalidades de contratación con el objetivo decidido de reforzar la estabilidad en el empleo y contener la temporalidad, respaldo a la flexibilidad interna frente a las medidas de ajuste más duras, y retoques en el modelo de negociación colectiva en términos de reequilibrio, se aborden otros significativos y relevantes aspectos del marco institucional del trabajo asalariado como el relativo a la participación y representación en la empresa, la conciliación corresponsable, las becas, el trabajo de los extranjeros, el nuevo estatuto del personal al servicio del hogar familiar, los planes de igualdad y protocolos de acoso, el futuro del modelo de indemnizaciones tasadas legalmente al término de la relación laboral o los desafíos que para el trabajo humano suponen los sistemas de inteligencia artificial.
INDEMNIZACIONES LEGALES TASADAS POR EXTINCIÓN DE LA RELACIÓN LABORAL. APUNTE CRÍTICO SOBRE LAS NUEVAS PROPUESTAS DE COMPLEMENTACIÓN JUDICIAL MEDIANTE COMPENSACIONES ADICIONALES
Authors: Fernández Márquez Óscar
Published: June 2024

Ha pasado ya un año y medio desde la promulgación y entrada en vigor del Real Decreto Ley 32/2021, de 28 de diciembre, de medidas urgentes para la reforma laboral, la garantía de la estabilidad en el empleo y la transformación del mercado de trabajo, un tiempo suficiente para poder hacer un balance mínimamente certero de sus efectos sobre el comportamiento del mercado de trabajo en nuestro país. Sin dejar de ser conscientes, como se destaca en el capítulo inicial, de que el complejo contexto socioeconómico y geopolítico en el que echaba a rodar este nuevo y ambicioso marco de ordenación del empleo y las relaciones laborales, caracterizado por una combinación realmente inusual de factores y variables, impide achacar a la reforma la íntegra responsabilidad de los aciertos o la falta de ellos. Esa es la principal finalidad del presente estudio, pero no la única, pues fiel a lo que indica el título de esta obra también tiene el propósito de ir algo más allá de convertirse en un comentario crítico más de la normativa reformada, e incorporar algunas propuestas con vistas a ese tan anunciado —y ahora de incierto pronóstico— Estatuto de los Trabajadores del siglo XXI. De ahí que junto a las materias centrales sobre las que recae la reforma de 2021, modalidades de contratación con el objetivo decidido de reforzar la estabilidad en el empleo y contener la temporalidad, respaldo a la flexibilidad interna frente a las medidas de ajuste más duras, y retoques en el modelo de negociación colectiva en términos de reequilibrio, se aborden otros significativos y relevantes aspectos del marco institucional del trabajo asalariado como el relativo a la participación y representación en la empresa, la conciliación corresponsable, las becas, el trabajo de los extranjeros, el nuevo estatuto del personal al servicio del hogar familiar, los planes de igualdad y protocolos de acoso, el futuro del modelo de indemnizaciones tasadas legalmente al término de la relación laboral o los desafíos que para el trabajo humano suponen los sistemas de inteligencia artificial.
DERECHO DEL TRABAJO Y SISTEMAS DE INTELIGENCIA ARTIFICIAL: DESAFÍOS Y RESPUESTAS
Authors: Rodríguez Cardo Iván
Published: June 2024

Ha pasado ya un año y medio desde la promulgación y entrada en vigor del Real Decreto Ley 32/2021, de 28 de diciembre, de medidas urgentes para la reforma laboral, la garantía de la estabilidad en el empleo y la transformación del mercado de trabajo, un tiempo suficiente para poder hacer un balance mínimamente certero de sus efectos sobre el comportamiento del mercado de trabajo en nuestro país. Sin dejar de ser conscientes, como se destaca en el capítulo inicial, de que el complejo contexto socioeconómico y geopolítico en el que echaba a rodar este nuevo y ambicioso marco de ordenación del empleo y las relaciones laborales, caracterizado por una combinación realmente inusual de factores y variables, impide achacar a la reforma la íntegra responsabilidad de los aciertos o la falta de ellos. Esa es la principal finalidad del presente estudio, pero no la única, pues fiel a lo que indica el título de esta obra también tiene el propósito de ir algo más allá de convertirse en un comentario crítico más de la normativa reformada, e incorporar algunas propuestas con vistas a ese tan anunciado —y ahora de incierto pronóstico— Estatuto de los Trabajadores del siglo XXI. De ahí que junto a las materias centrales sobre las que recae la reforma de 2021, modalidades de contratación con el objetivo decidido de reforzar la estabilidad en el empleo y contener la temporalidad, respaldo a la flexibilidad interna frente a las medidas de ajuste más duras, y retoques en el modelo de negociación colectiva en términos de reequilibrio, se aborden otros significativos y relevantes aspectos del marco institucional del trabajo asalariado como el relativo a la participación y representación en la empresa, la conciliación corresponsable, las becas, el trabajo de los extranjeros, el nuevo estatuto del personal al servicio del hogar familiar, los planes de igualdad y protocolos de acoso, el futuro del modelo de indemnizaciones tasadas legalmente al término de la relación laboral o los desafíos que para el trabajo humano suponen los sistemas de inteligencia artificial.
PROBING THE SHALLOWING BLR RESPONSE TO OPTICAL CONTINUUM IN AGN
Authors: Bon Edi , Panda S. , Bon N. , Marziani P.
Published: June 2024

Active galactic nuclei (AGN) can exhibit significant variability over time. In this study, we investigate the connection between optical continuum variability and the response of broad emission lines, aiming to probe the physical parameters of the broad-line region (BLR) plasma surrounding the supermassive black hole in AGN. Building upon previous research, we explore the relationship between optical continuum variability and the corresponding response of the Hβ emission line. Our goal is to elucidate the saturation effect of BLR luminosity with increasing AGN continuum, commonly referred to as the Pronik- Chuvaev effect. Employing a comprehensive, multi-component simultaneous spectral fitting approach across a range of spectral epochs, we generate continuum and Hβ light curves. Our observations reveal a clear trend of shallowing in the relationship between Hβ and continuum luminosities. To further investigate this trend, we conduct CLOUDY photoionization simulations, integrating a suitable broadband spectral energy distribution. Exploring a wide parameter space, we model the Hβ emission from the BLR using a constant density, single-cloud model. Our analysis successfully replicates the observed shallowing of the Hβ emission relative to the rising AGN continuum, offering insights into the local BLR densities and the spatial distribution of the Hβ-emitting region., , and P. Marziani
ELECTRON-MOLECULAR CATION COLLISIONS IN INTERSTELLAR SPACE
Authors: Iacob F.
Published: June 2024

In the interstellar medium, highly excited states of molecules can form a state of matter called Rydberg Matter. Mainly, they are formed by the promotion of an electron from the lower layers of the molecule to the highly excited ones. However, these can also be formed by temporarily capturing an electron in high energy orbitals following its collisions with cations. This paper focuses on the latter, the collisional approach, which is more suitable for explaining these highly excited states that can be found in this environment. It should be mentioned that in this environment cations are abundant and the probability of collision with electrons is high generating with high rates these highly excited states of the neutral called Rydberg states. It is found that low-energy electrons, such as those in the interstellar medium, generate these neutral capture states much more frequently. These results provide a quantitative description of Rydberg matter, which by its properties is a good candidate for dark matter. As a case study the molecular cation NS+ is considered as a target for obtaining strongly excited states of neutral NS after collisions with low energy electrons.
DATA REDUCTION AND MODELLING OF DUST EMISSION IN THREE NEARBY ACTIVE GALACTIC NUCLEI
Authors: Faniyi J. , Stalevski M. , Leftley J.
Published: June 2024

The aim of this thesis is to process and model infrared spectrophotometric observations of three objects from the AGN sample in which the existence of dust in the polar region was established: ESO 323-G77, ESO 428-14, NGC 5506. Both archival and new, previously unpublished observations from the VLT telescope at the Paranal Observatory in Chile will be included. For modelling, the classic dust torus model will be used as well as a new model that includes dusty winds in the form of a hollow cone in the polar region. The publicly available code CIGALE will be used for fitting. As the main result, the parameters of the geometry and physical properties of the dust will be determined. This will be the first step towards characterising the dusty winds of a larger sample of AGNs, with the aim of establishing the conditions under which they arise and how they affect the galaxies in which they are located., , and
ELECTRON IONIZATION CROSS SECTIONS FOR IRON IONS - REPRESENTATION IN DATA BASES
Authors: Marinković Bratislav P. , Ivanović S. Ð.
Published: June 2024

Chemical abundances in active galaxies has been recently studied by Flury and Moran (2020). The Seyfert 2 galaxy NGC 6552 shows a reflected X-ray spectrum with strong Kα lines of many neutral atoms from O, Ne, Mg till Fe and Ni (Reynolds et al. 1994). Since iron is the most abundant of the heavier elements in the Universe, the study of its Kα profiles is a powerful tool for investigating the innermost regions of AGN. These profiles show characteristic double-horn structure influenced by gravitational and Doppler effects (Middei, 2018). The formation of the H-like iron (Fe XXVI) Lyα line at 6.97 keV in the framework of current models for accretion into a black hole have been studied by Bautista and Titarchuk (1999). Iron Project (Hummer et al. 1993) has provided a vast amount of computed data on electron excitation cross sections and rates of astrophysical importance, together with radiative transition probabilities and photoionization cross sections mainly for ions of the iron-group elements. Within the scope of that project electron excitation of the fine-structure transitions in hydrogen-like ions He II and Fe XXVI had been determined (Kisielius et al. 1996). Experimental electronimpact ionization cross sections have been obtained by measuring the equilibrium ionization balance from X-ray measurements of radiative recombination into the K-shell of hydrogen-like and bare iron ions within an electron beam ion trap (O’Rourke et al. 2001). Existing electron-impact ionization cross sections have been reviewed recently by Kynien˙e et al. (2019) together with the presentation of the new set of data for Fe IX ion. Some of these cross sections may be found in BEAM data base (Marinković et al. 2017) as well as in several other AMO data bases what will be discussed during the presentation.
ENSEMBLE POWER SPECTRAL DENSITY OF QUASARS IN UV/OPTICAL BANDS
Authors: Petrecca V. , Papadakis I. E. , Paolillo M. , De Cicco D. , Bauer F. E.
Published: June 2024

Variability of AGN has proven to be a powerful tool to constrain the properties of the accretion process onto supermassive black holes and their surroundings. Correlations between UV/optical variability and physical properties have been long studied with a plethora of different approaches and time-domain surveys, although the detailed interplay between different emitting regions is not yet clear. Upcoming surveys such as the Legacy Survey of Space and Time (LSST) will revolutionize time domain astronomy by increasing both the size of the sample and the temporal baseline. I present a completely model independent study of quasar optical variability through ensemble power spectral density (PSD) of archival data collected from different surveys and reaching LSST-like temporal coverage. Variability does not depend on redshift, while both PSD amplitude and slope depend on black hole mass, accretion rate and rest-frame wavelength. There is also evidence for a universal PSD shape for all quasars, where frequencies scale with black hole mass while normalization and slopes are fixed, at any given wavelength and accretion rate. The proposed framework can show the potential LSST capabilities and can be applied to the upcoming data, shedding lighton the accretion mechanism of AGN.
UNVEILING GAMMA-RAY-EMITTING FR0 RADIO GALAXIES
Authors: Pannikkote Meghana , S. Paliya Vaidehi , Saikia D.J.
Published: June 2024

Fanaroff-Riley type 0 (FR0) radio galaxies are the latest entry in the jetted active galactic nuclei family. They are characterized by their compact radio morphology and similarities to host galaxy properties of FR I sources. We have recently identified, for the first time, seven gamma-ray emitting FR0s by leveraging the high-resolution radio and optical spectroscopic datasets provided by the ongoing wide-field sky surveys, e.g., the Very Large Array Sky Survey. The subsequent analysis of the multi-wavelength observations reveals the gamma rays to be produced by misaligned jets similar to more common FR I and II radio galaxies. While parsec-scale radio structures vary among FR0s, gamma-ray-detected ones often showcase dominant core emission with core-jet configurations. Further details of the findings will be presented. Unified Astronomy Thesaurus concepts: Fanaroff-Riley radio galaxies (526); BL Lac- ertae objects (158); Relativistic jets (1390); Gammaray sources (633)
Un viaje de ida y vuelta: de Asturias a Cuba. El miliciano Urbano Sánchez Rodríguez (1890-1937) y su tiempo
Authors: Quijada Álamo Diego
Published: June 2024

El presente trabajo reconstruye la trayectoria del emigrante y miliciano cenetista asturiano Urbano Sánchez Rodríguez (1890-1937), desde una dimensión histórica y social a través de un recorrido vital que se articula en torno a dos hechos destacados de la historia contemporánea de España. El primero se centra en el significado de la experiencia migratoria ultramarina, es decir, el viaje y su permanencia en Cuba. El segundo, en cambio, aborda su adhesión al anarcosindicalismo en Langreo en los años treinta, tras su regreso a España, y la participación en la Guerra Civil y su fatal desenlace.
Remember. Memorias traumáticas del terrorismo en el cine español e italiano
Authors: Barrenetxea Marañón Igor
Published: June 2024

El terrorismo ha sido, y sigue siendo, una amenaza a nivel global, un fenómeno que ha golpeado dura y específicamente a diversos países europeos. Entre ellos especialmente a España, con organizaciones como ETA, y a Italia, con las Brigadas Rojas. Este artículo, por lo tanto, pretende analizar varias películas de ficción españolas e italianas vinculadas a estos grupos para mostrar y ahondar en la faz traumática de su legado, ya sea tanto en las víctimas, por supuesto, como en el efecto negativo que provoca en sus propios activistas. El cine muestra, así, no solo una excelente capacidad de abordar, desde su especial narrativa visual, esa faz oscura del legado terrorista, sino cómo sirve también a la hora de reflexionar y tomar conciencia sobre su desgarrador efecto de cara al futuro.
Legitimación y represión política en Palencia durante el Trienio Liberal
Authors: Cruz Macho Fco. Javier de la
Published: June 2024

Tradicionalmente, el interior peninsular se ha considerado, durante el reinado de Fernando VII, como el principal baluarte del absolutismo. Pero las capitales de provincia, sin embargo, no fueron ajenas al liberalismo. Las instituciones políticas locales y la ciudadanía se movilizaron, durante el Trienio Liberal, con un gran dinamismo, poniendo de manifiesto la difusión del liberalismo en estas pequeñas ciudades del interior. El caso de Palencia es un ejemplo más de que la población y sus autoridades participaron activamente en el proceso de legitimación del nuevo régimen liberal. No es Palencia un caso aislado. Estudios sobre otras localidades castellanas y de otras zonas del interior han evidenciado una situación similar.
"Ocultando cantidades de mucha consideración": población y riqueza en el Diccionario de Madoz. El caso de Burgos (1845-1850)
Authors: Martín García Juan José
Published: June 2024

El reconocido y monumental Diccionario de Pascual Madoz muestra a lo largo y ancho de sus más de once mil páginas la ocultación de las referencias exactas sobre población y riqueza de las poblaciones españolas a mediados del siglo XIX. El propio Madoz fue consciente de este grave problema –tanto por basarse en la poco fiable Matrícula Catastral de 1842 como por las actitudes ocultistas de ciertos colaboradores de la obra–, que ofrecían cifras alternativas. A pesar de todo ello, esta cuestión no se ha revisado de manera específica por la historiografía española, reproduciéndose estos errores desde su publicación. Teniendo como marco analítico la extensa provincia de Burgos, y gracias a fuentes de mayor fidelidad, se pone de manifiesto el desmesurado grado de estas ocultaciones.
Evaluation of First Grade Intermediate Computer Curriculum in the Light of E-learning Requirements of the Islamic Schools teachers’ viewpoint
Authors: Hussein Taan. Ghazi
Published: June 2024

Article focuses on methods of evaluating curricula for the intermediate stage, determining e-learning requirements when preparing the content of computer curricula. The study is aimed to evaluate the computer curriculum for first intermediate grade from the viewpoint of computer teachers in the Religious Education and Islamic Schools in Iraq, during the academic year 2021-2022. In this study we have used the descriptive analytical, the study has included (68) samples of teachers, who have chosen randomly from the study community, which numbered (245) teachers and supervisors. We used the questionnaire as a research tool, that included (5) main axes, and included under it (53) paragraphs, which were judged and ensured its validity and reliability to infer the results, and was considered as a standard for the study. The study concluded that there is a weakness in the practical aspect of the computer curriculum for the first intermediate grade, and the lack of training activities in it, in addition to the shortcomings in its objectives that do not meet the needs of students. The study found a list of E-learning requirements that must be available in its components and used in determining the level of meeting the computer curriculum at this stage, with an indication of the strengths and weaknesses of the current curriculum. The study indicated that most teachers are not satisfied with the content of the current curriculum, which has been updated for more than 8 years ago.
‘Ambivalence’ as a Concept in John Clare's Middle and Late Poetry
Authors: KAMAL NIBRAS
Published: June 2024

This paper signifies the contradictory point of view in John Clare’s poetry. Clare (1794-1864) is an English romantic poetry in the nineteenth century, who writes more than ten volumes about nature. So, this study highlights the concept of Psychoanalytic theory which is ‘ambivalence’ and how through this theory can interpret any literary text on the basis of utilizing psychoanalytic methods to literary texts in order to reveal the author's inner emotions such as motives, dreams, as well as wishes. Consequently, the concept of  ‘ambivalence’ has a lot in common with the human psyche and its struggles. Sometimes the reader finds the author/poet talking about something real or a notion with pleasant sentiments, and then he refers to the same thing with sad sensations that are not as happy as the first ones without explanations. Here, the critic's job is to identify the reasons behind these contradicting emotions in the piece of literature. Then,  two long poems ("Summer Images" and "Child Harold") from different times show opposing perspectives of natural scenes in the poet's environment and abstract thoughts that revolve in his head. Another aspect is Clare’s insanity. Is it only an accusation, or is it true?. Finally, this critical study emphasises the idea that Clare’s poetry always reflects the inconsistency and instability of thoughts and feelings that the poet suffers from due to his irritated psychological and mental condition.
Prolegomena til en studie om den danske litteraturen i DDR
Authors: Jager Benedikt
Published: June 2024

Die DDR definierte sich gerne als Leseland und die Publikation ausländischer Literatur wurde häufig kulturpolitisch instrumentalisiert. Der folgende Beitrag gibt einen kurzen Überblick über die wichtigsten Funktionsmechanismen des literarischen Feldes der DDR, das seit 1963 von der Hauptverwaltung Verlage und Buchhandel als Zensurbehörde dominiert wurde. In dieser Abteilung des Kulturministeriums wurden alle Steuerungsmechanismen des DDR-Buchmarktes gebündelt. Ohne die Druckgenehmigung der HV Verlage und Buchhandel konnte keine Publikation in der DDR erscheinen. In einem zweiten Schritt soll der Literaturtransfer von Dänemark nach Ost-Berlin mit äußerst groben Strichen skizziert werden. Abschießend sollen die dargestellten Mechanismen anhand der Texte Peter Seebergs, die in der DDR publiziert wurden, näher erläutert und diskutiert werden. Hauptau- genmerk liegt hierbei auf der Kurzprosasammlung Die Frau im Fluß (1983).
Intercooperação e redes de cooperativas no Rio Grande do Sul
Authors: Leoní Albrecht Gazzoni Angélica
Published: June 2024

(Menção Honrosa 8º Prêmio ABEU 2022) Este livro circunda as diversas temáticas que envolvem o cooperativismo e a formação de redes, trazendo uma importante revisão dos aspectos que englobam a comercialização de alimentos pelas redes de cooperativas organizadas por agricultores e suas entidades representativas. Portanto, apresenta conteúdo de interesse do meio acadêmico das Ciências Agrárias e Sociais e serve de apoio atualizado sobre o tema e de embasamento teórico-prático aos técnicos, engenheiros e extensionistas da extensão rural ou da assistência técnica especializada, assim como aos cooperativistas, os quais, a partir do conteúdo apresentado, podem aperfeiçoar e/ou incorporar novos métodos de organização e administração cooperativa. Igualmente, interessa ao público geral que busca conhecer novos mecanismos de ação coletiva. Além disso, a obra traduz em suas entrelinhas a experiência de seis anos (2012 a 2018) da autora na execução do Programa de Extensão Cooperativa (PEC/RS), criado em 2011 no RS e executado pela Emater/RS através das sete Unidades de Cooperativismo (UCPs) formada por profissionais multidisciplinares com o objetivo de assessorar as cooperativas agropecuárias.
The Drosophila EcR-Hippo component Taiman promotes epithelial cell fitness by control of the Dally-like glypican and Wg gradient
Authors: Schweibenz Colby K. , Placentra Victoria C. , Moberg Kenneth H.
Published: June 2024

Rapidly dividing cells can eliminate slow growing neighbors through the apoptotic process of cell competition. This process ensures that only high fitness cells populate embryonic tissues and is proposed to underlie the ability of oncogene-transformed cells to progressively replace normal cells within a tissue. Patches of cells in the
Drosophila
wing disc overexpressing the oncogenic Taiman (Tai) transcriptional coactivator kill normal neighbors by secreting Spätzle ligands that trigger pro-apoptotic Toll signaling in receiving cells. However, extracellular signaling mechanisms responsible for elimination of slow growing cells by normal neighbors remain poorly defined. Here we show that slow growing cells with reduced Tai (Tai
low
) are killed by normal neighbors through a mechanism involving competition for the Wingless (Wg/Wnt) ligand. Elevated Wg signaling significantly rescues elimination of Tai
low
cells in multiple organs, suggesting that Tai may normally promote Wg activity. Examining distribution of Wg components reveals that Tai promotes extracellular spread of the Wg ligand from source cells across the wing disc, thus ensuring patterned expression of multiple Wg-regulated target genes. Tai controls Wg spread indirectly through the extracellular glypican Dally-like protein (Dlp), which binds Wg and promotes its extracellular diffusion and capture by receptors. Data indicate that Tai likely controls Dlp at two levels: transcription of
dlp
mRNA and Dlp intracellular trafficking. Overall, these data indicate that the Tai acts through Dlp to enable Wg transport and signaling, and that cell competition in the Tai
low
model arises due to inequity in the ability of epithelial cells to sequester limiting amounts of the Wg growth factor.
ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia
Authors: Wang Shimin , Wang Hongxian , Jin Bicheng , Yan Hongli , Zheng Qingliang , Zhao Dong
Published: June 2024

Non-obstructive azoospermia (NOA) belongs to male infertility due to spermatogenesis failure. However, evidence for cell type-specific abnormalities of spermatogenesis disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) and NOA. HE staining confirmed the structural abnormalities of the seminiferous tubules in NOA patients. We identified 12 germ cell subtypes (spermatogonial stem cell-0 (SSC0), SSC1, SSC2, diffing-spermatogonia (Diffing-SPG), diffed-spermatogonia (Diffed-SPG), pre-leptotene (Pre-Lep), leptotene-zygotene (L-Z), pachytene (Pa), diplotene (Di), spermatids-1 (SPT1), SPT2, and SPT3) and 8 Sertoli cell subtypes (SC1-SC8). Among them, three novel Sertoli cell subtypes phenotypes were identified, namely SC4/immature, SC7/mature, and SC8/further mature Sertoli cells. For each germ or Sertoli cell subtype, we identified unique new markers, among which immunofluorescence confirmed co-localization of ST3GAL4, A2M, ASB9, and TEX19 and DDX4 (classical marker of germ cell). PRAP1, BST2, and CCDC62 were co-expressed with SOX9 (classical marker of Sertoli cell) in testes tissues also confirmed by immunofluorescence. The interaction between germ cell subtypes and Sertoli cell subtypes exhibits stage-specific-matching pattern, as evidenced by SC1/2/5/7 involving in SSC0-2 development, SC3 participating in the whole process of spermiogenesis, SC4/6 participating in Diffing and Diffed-SPG development, and SC8 involving in the final stage of SPT3. This pattern of specific interactions between subtypes of germ cell and Sertoli cell was confirmed by immunofluorescence of novel markers in testes tissues. The interaction was mainly contributed by Notch1/2/3 signaling. Our study profiled the single-cell transcriptome of human spermatogenesis and provided many potentials molecular markers for developing testicular puncture specific marker kits for NOA patients.
Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae
Authors: Tleiss Fatima , Montanari Martina , Pierre Olivier , Royet Julien , Osman Dani , Gallet Armel , Kurz C. Léopold
Published: June 2024

Multiple gut antimicrobial mechanisms are coordinated in space and time to efficiently fight foodborne pathogens. In
Drosophila melanogaster
, production of reactive oxygen species (ROS) and antimicrobial peptides (AMPs) together with intestinal cell renewal play a key role in eliminating gut microbes. A complementary mechanism would be to isolate and treat pathogenic bacteria while allowing colonization by commensals. Using real-time imaging to follow the fate of ingested bacteria, we demonstrate that while commensal
Lactiplantibacillus plantarum
freely circulate within the intestinal lumen, pathogenic strains such as.
Erwinia carotovora
or
Bacillus thuringiensis
, are blocked in the anterior midgut where they are rapidly eliminated by antimicrobial peptides. This sequestration of pathogenic bacteria in the anterior midgut requires the Duox enzyme in enterocytes, and both TrpA1 and Dh31 in enteroendocrine cells. Supplementing larval food with hCGRP, the human homolog of Dh31, is sufficient to block the bacteria, suggesting the existence of a conserved mechanism. While the IMD pathway is essential for eliminating the trapped bacteria, it is dispensable for the blockage. Genetic manipulations impairing bacterial compartmentalization result in abnormal colonization of posterior midgut regions by pathogenic bacteria. Despite a functional IMD pathway, this ectopic colonization leads to bacterial proliferation and larval death, demonstrating the critical role of bacteria anterior sequestration in larval defense. Our study reveals a temporal orchestration during which pathogenic bacteria, but not innocuous, are confined in the anterior part of the midgut in which they are eliminated in an IMD pathway dependent manner.
Enhancing cross-evidence reasoning graph for document-level relation extraction
Authors: Pi Qiankun , Lu Jicang , Zhu Taojie , Sun Yepeng , Li Shunhang , Guo Jiaxing
Published: June 2024

The objective of document-level relation extraction (RE) is to identify the semantic connections that exist between named entities present within a document. However, most entities are distributed among different sentences, there is a need for inter-entity relation prediction across sentences. Existing research has focused on framing sentences throughout documents to predict relationships between entities. However, not all sentences play a substantial role in relation extraction, which inevitably introduces noisy information. Based on this phenomenon, we believe that we can extract evidence sentences in advance and use these evidence sentences to construct graphs to mine semantic information between entities. Thus, we present a document-level RE model that leverages an Enhancing Cross-evidence Reasoning Graph (ECRG) for improved performance. Specifically, we design an evidence extraction rule based on center-sentence to pre-extract higher-quality evidence. Then, this evidence is constructed into evidence graphs to mine the connections between mentions within the same evidence. In addition, we construct entity-level graphs by aggregating mentions from the same entities within the evidence graphs, aiming to capture distant interactions between entities. Experiments result on both DocRED and RE-DocRED datasets demonstrate that our model improves entity RE performance compared to existing work.
Escrituras de viaje y desplazamientos por América en los 60: itinerarios políticos y géneros literarios
Authors: Johansson M. María Teresa , Vergara R. Constanza
Published: June 2024

Este artículo propone una interpretación de las principales tendencias de las escrituras sobre viajes producidas durante la década de los sesenta en el Cono Sur. En este periodo escritores, periodistas, artistas, militantes y revolucionarios efectuaron diversos recorridos por América Latina guiados por itinerarios políticos. A partir del análisis de un corpus heterogéneo, compuesto por crónicas, diarios y otros géneros, se propone que estos desplazamientos generaron una cartografía particular que evidencia nuevas formas de escritura. El artículo aborda las principales características de estos textos entre las que se encuentran: la autorrepresentación de la figura del escritor desde una perspectiva relacional, la hibridación de narrativas con un discurso social y político, la elaboración de la coyuntura y la centralidad de la entrevista. Se trata de aspectos que dan cuenta discursivamente de las tendencias ideológicas imperantes en esta época.
Imitación, reescritura, traslación: una aproximación al "Glosario gongorino" de Óscar Castro
Authors: Joannon Felipe
Published: June 2024

El artículo propone una interpretación de la primera obra póstuma de Óscar Castro, el Glosario gongorino, publicado a modo de homenaje en 1948, con ocasión del primer aniversario de la muerte del poeta. Mediante un análisis comparativo entre los poemas que componen esta obra y los sonetos de Luis de Góngora cuyo último verso Castro glosa, se intenta definir el tipo de ejercicio poético que caracteriza a este opúsculo encomiástico. Para tal efecto, se presta atención a la reivindicación de la figura de Góngora que llevó adelante la generación española del 27, así como al papel que jugaron en la poesía chilena de los años 30 los denominados “poetas de la claridad”.
Phytochemical and Proximate Analysis of Sweet Potato (Ipomea batatas) Leaves Aqueous Extract and Its Prophylatic Effects on Pseudomonas aeruginosa Infected Catfish (Clarias gariepinus)
Authors: I. O. K. Ukwe, , S. N. Deekae,
Published: June 2024

The phytochemical and proximate analysis of sweet potato (Ipomea batatas) leaves were carried out to ascertain its bio-active compounds and proximate composition, and their importance in aquaculture. Subsequently, four different feeds were produced from a thirty-five (35) percent crude protein feed using I. batatas aqueous leaves extracts as follows: Do (Oml/kg); D1 (50ml/kg); D2 (100ml/kg) and D3 (150ml/kg). One hundred and fifty (150) sub-adult Clarias gariepinus were distributed to five groups in triplicate and designated as: D+ve (positive control); D-ve (negative control); D1; D2 and D3. While D+ve and D-ve were fed Do, D1 – D3 were fed 50ml/kg – 150ml/kg respectively. After eight weeks of feeding ten (10) fish from D-ve, D1 – D3 were infected intraperitoneal, with 1.5ml of 15 x 1010cfu/ml over night grown Pseudomonas aeruginosa and the fish in D+ve was not infected. After one week post infection period, the prophylactic effects of the I. batatas leaves extract were evaluated on the experimental fish following assessments on survival rate, disease resistance, condition factor and physicochemical parameters of the experimental waters. The results indicates as follows: proximate composition of I. batatas leaves contains fat, crude protein, crude fibre, ash and carbohydrate at different percentages, but they were higher in content in the dried leaves, but reverse was the case for moisture content. Phytochemical content of I. batatas leaves contains high percentage of alkaloids, phenols, flavonoids and Saponins with noticeable quantities of tannins, anthraquinones and coumarins; the survival rate and disease resistance indicates that D-ve recorded 46.66+11.54% and 0+0.00% respectively, while D+ve and D1 – D3 had 100+0.00% in both parameters; there were no significant difference in the dissolve oxygen, temperature and pH D+ve, D-ve and D1 – D3 but the value in D-v were lower compared to the rest. The values for conductivity and total dissolve solids (TDS) were significantly higher in D1-D3 compared to D+ve and D-ve, but the value of TDS was significantly lower in D+ve.
A Rare Ischemic Complication: Tricuspid Pillar Rupture after Anterior Myocardial Infarction
Authors: Rouam H. , Boutgourine M. , Zinneddine H. , Hazzazi I. , Dahioui A. , Abdou A. , Bouzerda A.
Published: June 2024

The rupture of the papillary muscle (PRM) after a myocardial infarction (MI) became rare since the introduction of primary angioplasty. In most cases in literature, it’s reported in the mitral valve. Followed by a PMR of the tricuspid valve (TV), which is extremely rare. We described a case of a 78-year-old patient, who was admitted to the emergency room for a delayed anterior ST elevation myocardial infarction. It was later complicated by papillary muscle rupture after a percutaneous coronary intervention (PCI) of the right coronary artery involving a stent.  The patient underwent surgical repair of the TV with fatal evolution.
Kitchen Layout Design and Individual Work Performance of Eatery in Davao Del Norte, Philippines
Authors: Aparece Aila Krisiel B. , Ayop Mary Grace T. , Ruz Angelica T. , Lazaro Angelica P.
Published: June 2024

This study assessed the level of kitchen layout design and individual work performance in eateries in Davao del Norte, Philippines. A descriptive-correlational research design was employed in this study to determine the relationship between the two variables. The respondents of this study were 207 employees of eateries in Davao del Norte, selected through a simple random sampling technique. Two adapted questionnaires were used, and the statistical tools included mean, Pearson r, and standard deviation. The findings of this study revealed that the level of kitchen layout design in terms of lighting, space or arrangement of kitchen equipment, and type of flooring was very high. The investigation also found that the level of individual work performance in terms of task performance, contextual performance, and counterproductive work behavior was very high, indicating that these behaviors were always manifest. Additionally, the study found a significant relationship between kitchen layout design and individual work performance, with an r value of 0.781 and a p-value of 0.000. Therefore, it was recommended to select a suitable kitchen layout design in eateries to enhance individual performance and workplace productivity. Future researchers were encouraged to continue exploring the space or arrangement of kitchen equipment to better manage kitchens and develop creative technologies for improved comprehension in these areas. Enhancing the study of task and contextual performance was suggested to emphasize human factor considerations and a holistic approach to boost productivity outcomes.
The Development of Detective Fiction: From Poe to Conan Doyle
Authors: Kanupriya Dr.
Published: June 2024

This paper traces the development of detective fiction from its origins with Edgar Allan Poe to its establishment as a literary genre by Arthur Conan Doyle. It examines key works and innovations of Poe and Doyle, analyzing their contributions to the genre's conventions and enduring popularity. Through a critical review of primary texts and secondary literature, this study highlights the evolution of detective fiction and its impact on modern literature. This paper aims to explore the development of detective fiction, beginning with Poe's pioneering contributions and culminating in Doyle's refinement and popularization of the genre. By examining the thematic and structural innovations introduced by these authors, we gain insight into how detective fiction evolved from a nascent form of literary entertainment into a complex and enduring genre.
Ecocriticism and the Pastoral Tradition in Romantic Poetry
Authors: Kanupriya Dr.
Published: June 2024

Ecocriticism, an interdisciplinary approach that examines the relationship between literature and the physical environment, has gained prominence in recent decades. This paper explores the interplay between ecocriticism and the pastoral tradition in Romantic poetry, focusing on the works of William Wordsworth, Samuel Taylor Coleridge, and John Clare. By examining the poets' depictions of nature, this study highlights how Romantic poetry reflects and critiques contemporary environmental concerns. The analysis underscores the relevance of Romantic pastoral poetry to modern ecological discourse and its potential to inspire environmental consciousness.