bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Indicators for Adaptive Human-Swarm Teaming
Authors: Hussein Aya , Ghignone Leo , Nguyen Tung , Salimi Nima , Nguyen Hung , Wang Min , Abbass Hussein A.
Published: February 2022

Swarm systems consist of large numbers of agents that collaborate autonomously. With an appropriate level of human control, swarm systems could be applied in a variety of contexts ranging from urban search and rescue situations to cyber defence. However, the successful deployment of the swarm in such applications is conditioned by the effective coupling between human and swarm. While adaptive autonomy promises to provide enhanced performance in human-machine interaction, distinct factors must be considered for its implementation within human-swarm interaction. This paper reviews the multidisciplinary literature on different aspects contributing to the facilitation of adaptive autonomy in human-swarm interaction. Specifically, five aspects that are necessary for an adaptive agent to operate properly are considered and discussed, including mission objectives, interaction, mission complexity, automation levels, and human states. We distill the corresponding indicators in each of the five aspects, and propose a framework, named MICAH (i.e., Mission-Interaction-Complexity-Automation-Human), which maps the primitive state indicators needed for adaptive human-swarm teaming.
Radial Transport of Energetic Electrons as Determined From the “Zebra Stripes” Measured in the Earth’s Inner Belt and Slot Region
Authors: Lejosne Solène , Fejer Bela G. , Maruyama Naomi , Scherliess Ludger
Published: February 2022

The “zebra stripes” are drift-periodic structures present in the form of peaks and valleys in energetic (tens to hundreds of keV) electron spectrograms in the Earth’s inner belt and slot region. Their characteristics inform of preceding electric field disturbances. Specifically, their amplitude contains information on the radial transport of trapped particles generated by azimuthal electric field disturbances. We introduce a method to quantify radial transport from the measured amplitude of the zebra stripes, and we apply it to the zebra stripes observed on 16 February 2014. The findings are compared with results from a particle tracing code that leverages an empirical analytical model for the electric field disturbances. The measured amplitude of the zebra stripes indicates that the electric field disturbances transported the trapped population coherently, over radial distances spanning several hundreds to thousands of kilometers. The magnitude of radial transport is shown to depend on angular drift frequency and initial location (equatorial radial distance and magnetic local time) in the disturbance. The model-observation comparison suggests that the timing for electric field variations provided by the model is valid for studying radial transport in the inner belt and slot region. On the other hand, we found discrepancies when comparing radial transport magnitudes. When assuming that radial transport varies as L3, as weakly suggested by the data for set angular drift frequencies, and extrapolating observations to L = 1, the amount of experimental transport obtained is two to three times greater than numerical estimates. Outputs from the standalone version of the Rice Convection Model (RCM) suggests that the electric field disturbances are likely greater than the estimates provided by the empirical model. RCM also supports the idea that radial transport driven by the prompt penetration of magnetospheric convection varies as L3 in the inner belt and slot region.
Commercial Seaweed Cultivation in Scotland and the Social Pillar of Sustainability: A Q-Method Approach to Characterizing Key Stakeholder Perspectives
Authors: Bjørkan Maiken , Billing Suzannah-Lynn
Published: February 2022

Finding the right way to move forward with seaweed cultivation requires the relevant stakeholders to reach agreement on what goals/limits to set and subsequently what measures should be taken to achieve them. Using a Q-method approach and an analytical framework based on in-put legitimacy and the four pillars of sustainability, we discuss the answers of a diverse set of stakeholders to the question: how should commercial seaweed cultivation in Scotland develop? Our results reveal three main discourses. The first focused on environmental and social sustainability, the second on accessing global markets, economic and environmental sustainability and the third prioritized jobs and social and institutional sustainability. The areas of consensus across the factors included the perception that large-scale and multi-national owned farms are not the ideal model for development of the industry in Scotland. All participants advised that the current regulatory regime for seaweed cultivation requires improvement. These results are discussed within the analytical framework and a prediction of the factors required to establish a legitimate seaweed cultivation industry in Scotland is presented.
Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
Authors: Wang Zhiwen , Chen Yuxin , Zhou Xinhui , Wang Changfeng , Chen Xianjun , Min Feixiang , Liu Ruen , Xiang Hui
Published: February 2022

Objective

Cerebrospinal fluid total protein (CSF-TP) levels in adults with posthemorrhagic hydrocephalus (PHH) are poorly studied. The objective of this study was to explore the characteristics of CSF-TP levels in patients with PHH.

Methods

The clinical data of 156 patients with hemorrhagic brain disease were retrospectively studied and divided into PHH and NPHH groups. Single-factor and multi-factor analyses were performed, and the key role of CSF-TP was evaluated using linear analysis.

Results

Among the 156 patients, 85 (54.5%) had PHH and 34 (21.8%) underwent surgeries. Hypertension (p = 0.017), days [total fever time when body temperature ≥ 38.5°C (p = 0.04)], Glasgow Coma Scale (GCS) score (p < 0.001), and time (from the onset of the disease to the obtainment of CSF-TP after lumbar puncture (p < 0.001) were important factors for PHH. Logistic regression analysis revealed that GCS score < 8 [odds ratio (OR) = 2.943 (1.421–6.097), p = 0.004] and CSF-TP × time ≥ 9,600 [OR = 2.317 (1.108–4.849), p = 0.026] were independent risk factors for PHH. All CSF-TP values were averaged every 2 days. CSF-TP was negatively correlated with time. Linear analysis showed that CSF-TP in the PHH group was higher than that in the NPHH group at the same onset time, and that the duration of detectionin the CSF was longer.

Conclusion

Cerebrospinal fluid total protein (CSF-TP) × time ≥ 9,600 and GCS score <8 were independent risk factors for PHH. CSF-TP was higher in the PHH group than in the NPHH group.
Pathological Features and Prognosis of Thymoma With or Without Myasthenia Gravis
Authors: Zhang Yunfeng , Yu Lei , Ke Ji
Published: February 2022

Introduction

To evaluate the different pathological and clinical characters of thymoma with and without myasthenia gravis (MG) and to determine whether the presence of MG influences the prognosis in patients with thymoma.

Methods

Four hundred and twenty-five consecutive patients operated was analyzed. A median sternotomy was used in 189 cases, and video-assisted thoracoscopic thymectomy was used in 236 cases. These patients with thymoma were subdivided into two groups: thymoma with myasthenia gravis MG (n = 220) and thymoma without MG (n = 205). All thymic epithelial tumors were classified according to the WHO histologic classification and the Masaoka clinical staging system. The result was evaluated according to the Myasthenia Gravis Foundation of America's criterion. The clinical features of the 2 test were compared between the two groups, and the survival analysis of Cox treatment effects was compared between the two groups.

Results

There were no perioperative deaths. The proportions of type A and thymic carcinoma were 0% in the group with MG and 10.7% (22/205) and 11.2% (23/205), respectively, in the group without MG. Thymic hyperplasia around the thymoma was 29.1% (64/220) in patients with MG and only 6.3% (13/205) in patients without MG (χ2 = 23.63, P = 0.000). The overall survival curve showed that the 5- and 10-year survival rates in the group without MG were 89.2 and 77.4%, respectively, while those in the MG group were 91.1 and 80.5%.

Conclusions

The existence of MG has little influence on the prognosis of thymomas, but it is suitable for early diagnosis and treatment. Extended thymectomy should be performed on all patients with thymoma, whether they have MG or not.
The Top-Cited Articles With a Focus on Barrett's Esophagus: A Bibliometric Analysis
Authors: Gan Peiling , Fan Wentao , Zhang Hailong , Zhong Chunyu , Xia Huifang , Lü Muhan , Zhou Xian , Tang Xiaowei
Published: February 2022

Background

Because the number of published literatures with a focus on Barrett's esophagus (BE) that researchers must be familiar with has quickly increased in recent years, the significance of selective searching and summarization of bibliometrics is also increasing. It is, thus, very important to find a method that can quickly and effectively search the most influential medical science articles. Therefore, the objective of this study was to use bibliometric analysis to assess and characterize the most influential articles involving BE research.

Methods

Publications on BE research were retrieved from the Web of Science Core Collection using the term “Barrett's esophagus.” Microsoft Excel 2016 and VOSviewer were used to further analyzed each article's citation number, title, journal, country, organization, category, and authorship.

Results

On 14 June 2020, 5,389 records of BE research published until 2020 were retrieved. The citation number of the top 100 most-cited articles ranged from 208 to 824. Gastroenterology published 29 articles, which accounted for the largest number of top 100 articles (29%); however, among the top 500 most-cited articles, the American Journal of Gastroenterology published the largest number. Of the top-cited articles, the USA was by far the leading country in BE research and contributed most of the articles (n = 72). Among the academic institutions that produced the top 100 most-cited articles, the University of Washington (n = 12) was dominant. Sharma Prateek (n = 6) authored the largest number of most-cited articles. The USA contributed the most articles per year, and the time trend of the number of top 500 articles increased by 38-fold between 1987 and 2000. “Adenocarcinoma,” “high-grade dysplasia,” “cancer,” “diagnosis,” and “dysplasia” were the most influential keywords.

Conclusions

This study not only presents a historical perspective but also facilitated the recognition of the significant advances in this area by researchers. Furthermore, the current study serves as a guide in decision clinical practice decision-making and provides a valuable reference for further research.
Sigmoid Colon Cancer Masquerading as a Right Incarcerated Inguinal Hernia: A Case Study and Literature Review
Authors: Zhang Jianfeng , Tang Yujie , Wu Xueliang , Wang Guiying , Li Tian
Published: February 2022

Background

Indirect inguinal hernia and sigmoid colon cancer are both common diseases, but carcinoma within the hernia sac is rare. We present a case of sigmoid colon cancer masquerading as a right incarcerated inguinal hernia. Since such a presentation is rare, and the correct diagnosis is usually made intraoperatively, there is still no consensus on the best treatment modality for such patients.

Case Presentation

A 70-year-old man presented to our hospital on September 20, 2020, with a right inguinal mass that had been painful for half a month, accompanied by symptoms of difficult defecation. The bulge was originally found at least 60 years before admission. There was no pain at the time; however, the mass enlarged progressively during the last 3 years. The right scrotum and groin area were obviously enlarged (~20 × 20 cm) and tender. Inside the scrotum, a circumscribed medium-hard mass (diameter 5 cm) that was palpable, with ill-defined borders and translational mobility was detected. The computed tomography (CT) scan showed a right blood vessel-containing strangulated inguinal hernia; the sigmoid colon showed focal wall thickening as it was in proximity to the inguinal hernia. Based on the biopsy results, a pathologic diagnosis of high-grade intraepithelial neoplasia was made. The preliminary diagnosis was that of sigmoid carcinoma and right incarcerated inguinal hernia. Emergency laparoscopic exploration, open sigmoid radical resection andright inguinal hernia repair were performed under general anesthesia. The patient recovered successfully and was discharged 1 week after the operation. One month after surgery, no discomfort and signs of recurrence were found.

Conclusions

The combination of colorectal cancer and inguinal hernia is uncommon, and detailed preoperative physical examination and imaging studies may contribute to the establishment of a correct diagnosis. The selection of appropriate surgical methods ensures good therapeutic results.
Analysis of the Effect of Phacoemulsification and Intraocular Lens Implantation Combined With Trabeculectomy on Cataract and Its Influence on Corneal Endothelium
Authors: Wang Bin , Tang Liqin
Published: February 2022

Objective

This study aimed to discuss the effect of phacoemulsification and intraocular lens implantation (PHACO + IOL) combined with trabeculectomy (TRAB) on cataracts and its influence on the corneal endothelium.

Methods

We selected 120 cataract patients admitted to our hospital from January 2018 to January 2021. According to different surgical methods, they were divided into the control group and the observation group. The observation group was treated with PHACO + IOL combined with TRAB, the control group only received PHACO. The clinical effect, ophthalmic-related parameters, corneal endothelium, complications, the satisfaction of the two groups were observed.

Results

The total effective rate and total satisfaction rate of the observation group were significantly higher than the control group (P < 0.05). One month after the operation, the vision and central anterior chamber depth of the observation group were higher than those of the control group, and intraocular pressure (IOP) was lower than that of the control group (P < 0.05). One month after the operation, the corneal endothelial cell area and cell density in the observation group were not significantly different from those before operation (P > 0.05). There was no significant difference in the total incidence of complications between the two groups (P > 0.05).

Conclusion

This study concluded that PHACO + IOL combined with TRAB has a good curative effect in the treatment of cataracts, which can improve the patients' vision and IOP, keep the functional integrity of corneal endothelial cells, and does not increase the occurrence of complications, the patients' satisfaction is high.
Conceptual System Dynamics and Agent-Based Modelling Simulation of Interorganisational Fairness in Food Value Chains: Research Agenda and Case Studies
Authors: McGarraghy Seán , Olafsdottir Gudrun , Kazakov Rossen , Huber Élise , Loveluck William , Gudbrandsdottir Ingunn Y. , Čechura Lukáš , Esposito Gianandrea , Samoggia Antonella , Aubert Pierre-Marie , Barling David , Đurić Ivan , Jaghdani Tinoush J. , Thakur Maitri , Saviolidis Nína M. , Bogason Sigurdur G.
Published: February 2022

System dynamics and agent-based simulation modelling approaches have a potential as tools to evaluate the impact of policy related decision making in food value chains. The context is that a food value chain involves flows of multiple products, financial flows and decision making among the food value chain players. Each decision may be viewed from the level of independent actors, each with their own motivations and agenda, but responding to externalities and to the behaviours of other actors. The focus is to show how simulation modelling can be applied to problems such as fairness and power asymmetries in European food value chains by evaluating the outcome of interventions in terms of relevant operational indicators of interorganisational fairness (e.g., profit distribution, market power, bargaining power). The main concepts of system dynamics and agent-based modelling are introduced and the applicability of a hybrid of these methods to food value chains is justified. This approach is outlined as a research agenda, and it is demonstrated how cognitive maps can help in the initial conceptual model building when implemented for specific food value chains studied in the EU Horizon 2020 VALUMICS project. The French wheat to bread chain has many characteristics of food value chains in general and is applied as an example to formulate a model that can be extended to capture the functioning of European FVCs. This work is to be further progressed in a subsequent stream of research for the other food value chain case studies with different governance modes and market organisation, in particular, farmed salmon to fillet, dairy cows to milk and raw tomato to processed tomato.
Development of SNP Marker Sets for Marker-Assisted Background Selection in Cultivated Cucumber Varieties
Authors: Lee Eun Su , Yang Hee-Bum , Kim Jinhee , Lee Hye-Eun , Lee Ye-Rin , Kim Do-Sun
Published: February 2022

Marker-assisted background selection is a powerful molecular tool that can enhance breeding efficiency through the analysis of a large number of markers representing the entire genomic background for precise selection. In the present study, the transcriptomes of 38 cucumber inbred lines with diverse traits were sequenced for single nucleotide polymorphism (SNP) mining for practical application to commercial cucumber breeding. A total of 62,378 high-quality SNPs were identified, of which 2462 SNPs were chosen based on the stringent filtering parameters. Finally, 363 evenly distributed common background selection markers (BMs) were developed and validated through polymorphism analysis and phylogenetic analysis using breeding materials with different genetic backgrounds; 327 out of 363 common BMs were useful for background selection. Moreover, the results of the phylogenetic analysis carried out using 50 selected core BMs were consistent with those for 327 common BMs. However, when the genotypes of breeding materials belonging to only the Baekdadagi-type were analyzed, the 327 common BMs showed a significant reduction in polymorphisms within the biased genomic locations. To address this issue, 59 highly polymorphic markers were selected as Baekdadagi BMs, as they showed better selection ability for the Baekdadagi-type. The 327 common BMs developed in the present study will enable efficient marker-assisted background selection in cucumber. Additionally, to reduce the genotyping cost, we suggested an alternative background selection strategy using both evenly distributed core BMs and biased Baekdadagi BMs for the improvement of commercial cucumber breeding programs.
A Metallochaperone HIPP33 Is Required for Rice Zinc and Iron Homeostasis and Productivity
Authors: Cao Hong Wei , Li Cao , Zhang Bai Qing , Rono Justice Kipkorir , Yang Zhi Min
Published: February 2022

Both zinc (Zn) and iron (Fe) are essential micro-nutrients for plant growth and development, yet their levels in plants are tightly regulated to prevent either deficiency or phytotoxicity. In agronomic reality, such an imbalance of metal bioavailability to crops occurs frequently. Thus, mining genetic resources to improve crop traits relevant to metal homeostasis is a great challenge to ensure crop yield and food quality. This study functionally identified an uncharacterized metallochaperone family HIPP protein gene Heavy Metal Associated Isoprenylated Plant Proteins 33 (OsHIPP33) in rice (Oryza sativa). OsHIPP33 resides in the nucleus and plasma membrane and constitutively expresses throughout the lifespan. Transcription of OsHIPP33 is not induced by deprivation of Zn and Fe but upregulated under excessive Zn and Fe stress. In a short-term (one month) hydroponic study with the normal Zn and Fe supply, there were no significant changes in the growth and metal accumulation between the knockout (OsHIPP33) or knockdown (RNA interference) mutant lines and wild-type, while the long-term field trials (for two successive years) demonstrated that the mutation of OsHIPP33 significantly compromised the rice growth and development (such as rice leave tissues, panicle length, spikelet fertility, seed weight per plant, 1000-grain weight, etc.), with the mature grain yield of OsHIPP33 and RNAi lines reduced by 52% and 12–15% respectively, compared with wild-type. Furthermore, the accumulation of Zn and Fe in rice straw, husk and brown rice was also reduced. These results suggest that the disruption of OsHIPP33 can dampen rice agronomic traits, signifying that OsHIPP33 expression is required for Zn and Fe homeostasis and subsequent production of rice grains.
The Response of Globe Artichoke Plants to Potassium Fertilization Combined with the Foliar Spraying of Seaweed Extract
Authors: Petropoulos Spyridon A. , Sami Rokayya , Benajiba Nada , Zewail Reda M. Y. , Mohamed Mustafa H. M.
Published: February 2022

This work investigated the effects of potassium mineral fertilizers, combined with biofertilizers (T1–T4 treatments) and the foliar spraying of seaweed extract (at 1 g/L, 2 g/L, and 3 g/L) on the vegetative growth characters, chemical constituents of foliage, and the yield and quality parameters of globe artichoke. The maximum height, and the fresh and dry weight of the leaves, was recorded in plants that received only soil with added potassium (T1 treatment) and sprayed with seaweed extract at 3 g/L. Furthermore, the highest number of offshoots per plant was registered in the T2 treatment combined with seaweed extract (3 g/L). T1 and T2 treatments resulted in the highest values of leaf N, P, K, and total carbohydrate content when combined with seaweed extract (3 g/L). The highest numbers of early, late, and total heads per plant were obtained for the T1 treatment and seaweed extract (3 g/L). Similarly, most of the head quality parameters were beneficially affected by the T2 treatment and seaweed extract (3 g/L). In conclusion, it is suggested that soil application of mineral potassium fertilizer (75% of RD) combined with biofertilizer (25% of RD) and the foliar spraying of seaweed extracts at 3 g/L, was most beneficial for the yield and quality parameters of globe artichoke plants.
Growth and Fatty Acid Composition of Black Soldier Fly Hermetia illucens (Diptera: Stratiomyidae) Larvae Are Influenced by Dietary Fat Sources and Levels
Authors: Li Xiangce , Dong Yewei , Sun Qiuxuan , Tan Xiaohong , You Cuihong , Huang Yanhua , Zhou Meng
Published: February 2022

A 16-day rearing trial was performed to investigate the influence of two supplemental levels (5% and 10%) of six dietary fat sources (linseed oil, peanut oil, coconut oil, soybean oil, lard oil and fish oil) on the growth, development and nutrient composition of black solider fly larvae. Our results demonstrated that the pre-pupa rate of larvae was linearly influenced by dietary C18:0, C18:3n-3 and C18:2n-6 content (pre-pupa rate = 0.927 × C18:0 content + 0.301 × C18:3n-3 content-0.258 × C18:2n-6 content p < 0.001)), while final body weight was linearly influenced by that of C16:0 (final body weight = 0.758 × C16:0 content, p = 0.004). Larval nutrient composition was significantly affected by dietary fat sources and levels, with crude protein, fat and ash content of larvae varying between 52.0 and 57.5, 15.0 and 23.8, and 5.6 and 7.2% dry matter. A higher level of C12:0 (17.4–28.5%), C14:0 (3.9–8.0%) and C16:1n-9 (1.3–4.3%) was determined in larvae fed the diets containing little of them. In comparison, C16:0, C18:1n-9, C18:2n-6 and C18:3n-3 proportions in larvae were linearly related with those in diets, with the slope of the linear equations varying from 0.39 to 0.60. It can be concluded that sufficient C16:0, C18:0 and C18:3n-3 supply is beneficial for larvae growth. Larvae could produce and retain C12:0, C14:0, and C16:1n-9 in vivo, but C16:0, C18:1n-9, C18:2n-6 and C18:3n-3 could only be partly incorporated from diets and the process may be enhanced by a higher amount of dietary fat. Based on the above observation, an accurately calculated amount of black soldier fly larvae could be formulated into aquafeed as the main source of saturated fatty acids and partial source of mono-unsaturated and poly-unsaturated fatty acids to save fish oil.
Reduction in Pathogenicity in Yeast-like Fungi by Farnesol in Quail Model
Authors: Sachivkina Nadezhda , Vasilieva Elena , Lenchenko Ekaterina , Kuznetsova Olga , Karamyan Arfenia , Ibragimova Alfia , Zhabo Natalia , Molchanova Maria
Published: February 2022

Candida albicans was the first eukaryotic microorganism to exhibit quorum-sensing through the secretion of the sesquiterpene E, farnesol. This molecule is generated by dephosphorylation of farnesyl pyrophosphate in the mevalonate biosynthetic pathway in mammalian and yeast cells. Exogenous farnesol inhibits yeast-to-hyphal formation in a concentration- and time-dependent manner at the earliest stage of hyphal development. Much research has been devoted to studying the role of farnesol as an inhibitor of hyphal morphogenesis; however, little research has been published regarding the in vivo impacts of farnesol on fungal virulence and the development of Candida infection. While other studies have examined the impact of multiple doses of farnesol in addition to antimycotics, we hypothesize that C. albicans treated with a single dose of this quorum-sensing molecule could reduce fungal virulence in a quail model.
Animal Welfare and Food Safety When Slaughtering Cattle Using the Gunshot Method
Authors: Hultgren Jan , Schiffer Katrin J. , Babol Jakub , Berg Charlotte
Published: February 2022

Transporting cattle from farm to slaughterhouse is often stressful for the animal, which can impair the meat quality. With the gunshot method, the animal is stunned with a rifle shot while together with familiar herd members in their home environment, exsanguinated and transported to a nearby slaughterhouse. Aiming to assess the consequences for animal welfare and food safety, 20 Hereford steers aged 18–54 months were shot with .22 Magnum ammunition from an elevated position and distance of 6–12 m. Each time, only one out of four to seven animals in a 16 × 10 m corral was shot. Dressing was done on farm. Based on the animals’ behaviour and blood concentrations of cortisol, glucose and lactate, stress levels before shooting were low. Eleven animals were deeply stunned, the consciousness of seven others was ambiguous, and two were poorly stunned. Two animals were reshot. The bleed-out was satisfactory for all animals, and little or no faecal contamination was found on the carcasses. We conclude that the gunshot method is applicable to large beef steers while maintaining a satisfactory level of animal welfare and food safety, provided that the necessary conditions can be attained.
Multi-Drug Resistant Escherichia coli, Biosecurity and Anti-Microbial Use in Live Bird Markets, Abeokuta, Nigeria
Authors: Adebowale Oluwawemimo , Makanjuola Motunrayo , Bankole Noah , Olasoju Mary , Alamu Aderonke , Kperegbeyi Eniola , Oladejo Oladotun , Fasanmi Olubunmi , Adeyemo Olanike , Fasina Folorunso O.
Published: February 2022

Live bird markets (LBM) remain a critical link from farm to fork in the poultry value chain, which oftentimes promotes indiscriminate antimicrobial use (AMU) and resistance (AMR). In this study, we assessed biosecurity practices, AMU, and associated these with multidrug resistant (MDR) E. coli in LBMs in Abeokuta, Ogun State. A cross-sectional survey among live bird sellers (LBS) in eight LBMs was conducted using a semi-structured questionnaire. Also, cloacal samples (n = 200) were randomly collected and pooled for bacteriological detection of MDR E. coli in live chickens of consenting LBS. Susceptibility to 14 antimicrobials belonging to 6 different classes was determined using the disk diffusion method. Biosecurity level and AMU were generally low. LBS less than 46 years were 6.8- fold more likely to fall within the poor biosecurity level (Crudes odds ratio = 6.8; 95% CI; 1.20–38.56; p = 0.03) than others. An informal or primary school education increased the odds of having a poor practice of AMU by 15.1 folds (Crudes odds ratio = 15.1; 95% CI; 2.73–84.18; p = 0.002) than those with secondary or tertiary. The prevalence of E. coli and MDR E. coli at the LBM level were 80% and 56.3%, respectively. Extremely high resistance rates were observed for ceftazidime (96.9%) and imipenem (90.6%). The odds of MDR E. coli increased eight-fold in poultry kept by LBS who use AMs as prophylaxis. This current data could be useful for the development of targeted behavioral risk communication and mitigation strategies for AMR to impede the potential horizontal transfer of AMR genes to humans through animal-sourced food.
Factors Associated with Daptomycin-Induced Eosinophilic Pneumonia
Authors: Ishikawa Kazuhiro , Matsuo Takahiro , Tsuda Yasumasa , Rahman Mahbubur , Uehara Yuki , Mori Nobuyoshi
Published: February 2022

The risk factors for eosinophilic pneumonia (EP) remain unclear. We investigate the characteristics of patients with daptomycin (DAP)-induced EP and conducted a retrospective observational study. A total of 450 patients aged ≥ 18 years who received DAP (25 DAP with EP, 425 DAP without EP) were included. The median duration from the first DAP administration to EP onset was 18.0 days. Definite, probable, and possible DAP-induced EP were diagnosed in 0, 9, and 16 patients, respectively. The median age (DAP with EP, 72.0 years; DAP without EP, 64.0 years), DAP dosage/body weight (BW) (9.00 vs. 7.50 mg/kg), blood eosinophil count (cells/μL) (419 vs. 96), and the percentage of hemodialyzed patients (40.0% vs. 13.4%) were significantly higher in patients with EP than in patients without EP in the univariate analysis. In separate multivariate logistic regression analyses, age (odds ratio (OR), 1.03; 95% confidence interval (CI), 1.00–1.05), DAP dosage/BW (OR, 1.61; 95% CI, 1.25–2.07), and hemodialysis (OR, 4.42; 95% CI, 1.86–10.5) were significantly associated with DAP-induced EP. Clinicians may need to consider the potential factors associated with EP, especially in older patients, patients on hemodialysis, or patients who receive > 9.00 mg/kg of DAP.
Impact of the Stringent Stress Response on the Expression of Methicillin Resistance in Staphylococcaceae Strains Carrying mecA, mecA1 and mecC
Authors: Milheiriço Catarina , Tomasz Alexander , de Lencastre Hermínia
Published: February 2022

The acquisition of the resistance determinant mecA by Staphylococcus aureus is of major clinical importance, since it confers a resistant phenotype to virtually the entire large family of structurally diverse β-lactam antibiotics. While the common resistance determinant mecA is essential, the optimal expression of the resistance phenotype also requires additional factors. Previous studies showed that the great majority of clinical isolates of methicillin-resistant S. aureus (MRSA) have a heterogeneous resistant phenotype, and we observed that strains carrying methicillin genetic determinants other than mecA also produce similar heterogeneous phenotypes. All these strains were able to express high and homogeneous levels of oxacillin resistance when sub-inhibitory concentrations of mupirocin, an effector of the stringent stress response, were added to growth media. Our studies show that the gene gmk, involved in guanine metabolism, was one of the first genes to exhibit mutations in homoresistant (H*R) derivatives obtained through serial passages (with increasing concentrations of oxacillin) of the prototype mecC-carrying MRSA strain LGA251. All these observations led us to propose that a common molecular mechanism for the establishment of high and homogeneous oxacillin resistance must be present among isolates carrying different methicillin resistance determinants. In this work, we tested this hypothesis using whole-genome sequencing (WGS) to compare isogenic populations differing only in their degrees of oxacillin resistance and carrying various methicillin genetic determinants
Picrasma quassioides (D.DON) Benn. Ethanolic Extract Improves Atopic Dermatitis and Hyperactivity Disorder in DNCB-Treated BALB/c Mice
Authors: Choi Min-Jin , Nguyen Ly Thi Huong , Shin Heung-Mook , Yang In-Jun
Published: February 2022

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that can be associated with psychiatric disorders. Picrasma quassioides (D.Don) Benn (Gomokpi, GMP), a traditional medicinal herb, has been used to treat skin diseases, including AD. The current study examined the effects of an ethanolic extract of GMP on 2,4-dinitrochlorobenzene (DNCB)-induced AD mice. The severity of skin symptoms and behavioral changes in AD mice were evaluated. GMP alleviated the AD-like skin inflammation and hyperlocomotion activity in DNCB-treated BALB/c mice. The effects of GMP behavioral abnormalities might occur by inhibiting TNF-α production in the PFC. GMP suppressed the production of TARC (Th2 chemokine) in TI-stimulated HaCaT keratinocytes. Moreover, GMP also exerted immunosuppressive effects by reducing TNF-α production in LPS-stimulated Raw264.7 macrophages, IL-17 expression in PI-stimulated EL4 cells, and VEGF secretion in SP-stimulated HMC-1 cells. These findings suggest that GMP could be useful for treating AD by modulating inflammatory responses and comorbid behavioral changes.
Assessing Robustness of Morphological Characteristics of Arbitrary Grayscale Images
Authors: Smolyar Igor , Smolyar Daniel
Published: February 2022

In our previous work, we introduced an empirical model (EM) of arbitrary binary images and three morphological characteristics: disorder of layer structure (DStr), disorder of layer size (DSize), and pattern complexity (PCom). The basic concept of the EM is that forms of lines play no role as a morphological factor in any narrow area of an arbitrary binary image; instead, the basic factor is the type of line connectivity, i.e., isotropic/anisotropic connections. The goal of the present work is to justify the possibility of making the EM applicable for the processing of grayscale arbitrary images. One of the possible ways to reach this goal is to assess the influence of image binarization on the robustness of DStr and DSize. Images that exhibit high and low edge gradient are used for this experimental study. The robustness of DStr and DSize against the binarization procedure is described in absolute (deviation from average) and relative (Pearson’s coefficient correlation) terms. Images with low edge gradient are converted into binary contour maps by applying the watershed algorithm, and DStr and DSize are then calculated for these maps. The robustness of DStr and DSize were assessed against the image threshold for images with high edge gradient and against the grid size of contour maps and Gaussian blur smoothing for images with low edge gradient. Experiments with grayscale arbitrary patterns, such as the surface of Earth and Mars, tidal sand ripples, turbulent flow, a melanoma, and cloud images, are presented to illustrate the spectrum of problems that may be possible to solve by applying the EM. The majority of our experiments show a high level of robustness for DStr and DSize.
A Machine Learning Model for the Prediction of Concrete Penetration by the Ogive Nose Rigid Projectile
Authors: Imran Latif Qadir Bux alias , Memon Zubair Ahmed , Mahmood Zafar , Qureshi Mohsin Usman , Milad Abdalrhman
Published: February 2022

In recent years, research interest has been revolutionized to predict the rigid projectile penetration depth in concrete. The concrete penetration predictions persist, unsettled, due to the complexity of phenomena and the continuous development of revolutionized statistical techniques, such as machine learning, neural networks, and deep learning. This research aims to develop a new model to predict the penetration depth of the ogive nose rigid projectile into concrete blocks using machine learning. Genetic coding is used in Python programming to discover the underlying mathematical relationship from the experimental data in its non-dimensional form. A populace of erratic formulations signifies the rapport amid dependent parameters, such as the impact factor (I), the geometry function of the projectile (N), the empirical constant for concrete strength (S), the slenderness of the projectile (λ), and their independent objective variable, X/d, where X is the penetration depth of the projectile and d is the diameter of the projectile. Four genetic operations were used, including the crossover, sub-tree transfiguration, hoist transfiguration, and point transfiguration operations on supervised test datasets, which were divided into three categories, namely, narrow penetration (X/d < 0.5), intermediate penetration (0.5 ≤ X/d < 5.0), and deep penetration (X/d ≥ 5.0). The proposed model shows a significant relationship with all data in the category for medium penetration, where R2 = 0.88, and R2 = 0.96 for deep penetration. Furthermore, the proposed model predictions are also compared with the most commonly used NDRC and Li and Chen models. The outcome of this research shows that the proposed model predicts the penetration depth precisely, compared to the NDRC and Li and Chen models.
Interpolating the Directional Room Impulse Response for Dynamic Spatial Audio Reproduction
Authors: Zhao Jiahong , Zheng Xiguang , Ritz Christian , Jang Daeyoung
Published: February 2022

Virtual reality (VR) is increasingly important for exploring the real world, which has partially moved to virtual workplaces. In order to create immersive presence in a simulated scene for humans, VR needs to reproduce spatial audio that describes three-dimensional acoustic characteristics in the counterpart physical environment. When the user moves, this reproduction should be dynamically updated, which provides practical challenges because the bandwidth for continuously transmitting audio and video scene data may be limited. This paper proposes an interpolation approach for dynamic spatial audio reproduction using acoustic characteristics of direction and reverberation at limited numbers of positions, which are represented using a first order Ambisonics encoding of the room impulse response (RIR), called the directional RIR (DRIR). We decompose two known DRIRs into reflection components, before interpolating early dominant components for DRIR synthesis and utilizing DRIR recordings for accuracy evaluation. Results indicate that the most accurate interpolation is obtained by the proposed method over two comparative approaches, particularly in a simulated small room where most direction of arrival estimation errors of early components are below five degrees. These findings suggest precise interpolated DRIRs with limited data using the proposed approach, which is vital for dynamic spatial audio reproduction for VR applications.
Similarities and Differences in Quorum Sensing-Controlled Bioluminescence between Photobacterium phosphoreum T3 and Vibrio qinghaiensis sp.-Q67
Authors: Wang Dan , Bai Linming , Li Shanshan , Yan Wei
Published: February 2022

Quorum sensing is a density-dependent mechanism using chemical signal molecules termed autoinducers to regulate diverse biological processes in bacteria, including bioluminescence. However, the correlation between growth and light emission of two typical luminescent bacteria, Photobacterium phosphoreum T3 and Vibrio qinghaiensis sp.-Q67, is still unclear. This study investigates the variations of bioluminescence and the light-emission-involved gene expression of the above two strains, respectively, showing that bioluminescence is population density-dependent. Furthermore, the effect of crude extracts (175, 350, 700 and 1750 mg/L) from the bacterial culture that contains the potential autoinducers on the bioluminescence is explored. At the exponential and the early stationary growth phase, T3 did not exhibit an obvious light intensity and cell density change after adding crude extracts at 175 and 350 mg/L, while the light intensity decreased at 700 and 1750 mg/L, showing a luminescence inhibition. For Q67, the light intensity increased dramatically with crude extract concentration. These results suggest that the bioluminescence process of both T3 and Q67 is controlled by quorum sensing. Furthermore, the different response modes of these two strains to autoinducers imply that the two strains could be applied to different compounds for toxicity assesses.
Distribution System State Estimation Using Model-Optimized Neural Networks
Authors: Kim Doyun , Dolot Justin Migo , Song Hwachang
Published: February 2022

Maintaining reliability during power system operation relies heavily on the operator’s knowledge of the system and its current state. With the increasing complexity of power systems, full system monitoring is needed. Due to the costs to install and maintain measurement devices, a cost-effective optimal placement is normally employed, and as such, state estimation is used to complete the picture. However, in order to provide accurate state estimates in the current power system climate, the models must be fully expanded to include probabilistic uncertainties and non-linear assets. Recognizing its analogous relationship with state estimation, machine learning and its ability to summarily model unseen and complex relationships between input data is used. Thus, a power system state estimator was developed using modified long short-term (LSTM) neural networks to provide quicker and more accurate state estimates over the conventional weighted least squares-based state estimator (WLS-SE). The networks are then subject to standard polynomial scheduled weight pruning to further optimize the size and memory consumption of the neural networks. The state estimators were tested on a hybrid AC/DC distribution system composed of the IEEE 34-bus AC test system and a 9-bus DC microgrid. The conventional WLS-SE has achieved a root mean square error (RMSE) of 0.0151 p.u. for voltage magnitude estimates, while the LSTM’s were able to achieve RMSE’s between 0.0019 p.u. and 0.0087 p.u., with the latter having 75% weight sparsity, estimates about ten times faster, and half of its full memory requirement occupied.
Investigation of the Influence of Neutron Irradiation on Cladded Nuclear Reactor Pressure Vessel Steel Blocks by Magnetic Adaptive Testing
Authors: Vértesy Gábor , Gasparics Antal , Szenthe Ildikó , Uytdenhouwen Inge
Published: February 2022

The influence of neutron irradiation degradation on reactor pressure vessel steel was investigated. Large blocks were irradiated by neutrons in the BR2 reactor at a low irradiation temperature. They were measured by a nondestructive magnetic method, magnetic adaptive testing, before and after the neutron irradiation. It was shown that the modification of the magnetic parameters due to the neutron irradiation was well detectable by this nondestructive method. It was also shown that the influence of neutron irradiation could be detected with a reasonable signal-to-noise ratio through the cladding. The present results are considered as a first step towards the application of magnetic adaptive testing in the nuclear industry.
Machine Learning-Based Highway Truck Commodity Classification Using Logo Data
Authors: He Pan , Wu Aotian , Huang Xiaohui , Rangarajan Anand , Ranka Sanjay
Published: February 2022

In this paper, we propose a novel approach to commodity classification from surveillance videos by utilizing logo data on trucks. Broadly, most logos can be classified as predominantly text or predominantly images. For the former, we leverage state-of-the-art deep-learning-based text recognition algorithms on images. For the latter, we develop a two-stage image retrieval algorithm consisting of a universal logo detection stage that outputs all potential logo positions, followed by a logo recognition stage designed to incorporate advanced image representations. We develop an integrated approach to combine predictions from both the text-based and image-based solutions, which can help determine the commodity type that is potentially being hauled by trucks. We evaluated these models on videos collected in collaboration with the state transportation entity and achieved promising performance. This, along with prior work on trailer classification, can be effectively used for automatically deriving commodity types for trucks moving on highways.
Derivation of High-Resolution Meteorological Parameters for Use in Airport Wind Shear Now-Casting Applications
Authors: Stocker Jenny , Johnson Kate , Forsyth Ella , Smith Stephen , Gray Stephanie , Carruthers David , Chan Pak-Wai
Published: February 2022

Methods for now-casting adverse weather conditions with the potential to cause disruption to aircraft landings often make use of real-time measurements at high temporal resolution. This paper describes processing methodologies developed to derive meteorological parameters from such measurements recorded in the vicinity of Hong Kong International Airport, specifically a radiometer in King’s Park, a wind profiler and surface anemometer on Cheung Chau Island and weather buoys in the Pearl River estuary. These parameters are suitable for use as input to a now-casting application of the computationally efficient airflow model, FLOWSTAR, which has previously been shown to predict mountain waves generated by flow over Lantau Island to the southeast of the airport. Radiosonde data from King’s Park have been used to test the radiometer processing method; the novel approach of using minimum and maximum potential temperature deviations from a series of height-dependent linear profiles to derive radiometer inversion layer parameters generates data that compares well with values derived from corresponding radiosonde profiles. Mountain wave strength depends on the magnitude of wind speed in the inversion layer; wind profiler data can be used to estimate typical and maximum wind speeds and associated wind directions using estimates of inversion layer depth derived from the radiometer data. With estimates of surface sensible heat flux appropriate for the airport’s coastal location calculated using a marine boundary layer scheme, a dataset of meteorological parameters at 20-min resolution has been derived for input into the FLOWSTAR model. The combination of automated meteorological data processing methods and flow field modelling has the potential to form part of a now-casting system for determining strong wind shear conditions at the airport.