bluuebunny/crossref_metadata_2025 huggingface dataset:
Ghost imaging of blurred object based on deep-learning
Authors: Zhang Zijin , Wang Chunfang , Gong Wenlin , Zhang Dawei
Published: April 2021

In this paper, a new, to the best of our knowledge, neural network combining a new residual neural network (ResNetV2), the residual dense block (RDB), and eHoloNet is proposed to reconstruct a blurred object. With the theory of ghost imaging, only the bucket signal that passes through the blurred object is necessary for reconstruction. The training sets are ENMNIST, which is used for simulation, and the blurred object is designed by Airy convolution. To test the generalization of the neural network, we use multi-slit as the testing sets. Both simulated and experimental results show that the trained neural network is superior in a generalized reconstruction of the blurred object. In addition, the limitation of the reconstruction is also explained in this work.
Terahertz focusing metalens of reflectionless meta-atoms with negative refractive indices
Authors: Nakao Haruaki , Kondoh Satoshi , Suzuki Takehito
Published: April 2021

Terahertz continuous-wave (CW) sources oscillating around the 1.0 THz band at room temperature have rapidly been developed to bridge the terahertz gap. However, reflectionless metasurfaces suitable for integration with terahertz CW sources as optical components have yet to be developed in the terahertz gap. Here, we propose a terahertz-focusing metalens consisting of reflectionless meta-atoms with a discrete distribution of negative refractive indices from

−

1.1

to

−

2.8

. The proposed 2D gradient-refractive-index metalens converts an incident terahertz Gaussian beam to a line focus. We also experimentally demonstrate a metasurface of reflectionless meta-atoms with a negative refractive index of

−

2.8

adopted in the periphery of the metalens. The reflectionless metasurface in the terahertz gap would be a welcome contribution to the rapid growth of terahertz industrial applications with terahertz CW sources. Further, the design approach based on reflectionless meta-atoms with negative refractive indices could be applied to various 2D planar optical components with attractive functionalities such as collimating, arbitrary wavefront shaping, and light vortices.
THz-TDS parameter extraction: empirical correction terms for the analytical transfer function solution
Authors: Gorecki Jon , Apostolopoulos Vasilis
Published: April 2021

Terahertz time-domain spectroscopy (TDS) is capable of determining both real and imaginary refractive indices of a wide range of material samples; however, converting the TDS data into complex refractive indices typically involves iterative algorithms that are computationally slow, involve complex analysis steps, and can sometimes lead to non-convergence issues. To avoid using iterative algorithms, it is possible to solve the transfer function analytically by assuming the material loss is low; however, this leads to errors in the refractive index values. Here we demonstrate how the errors created by solving the transfer function analytically are largely predictable, and present a set of empirically derived equations to diminish the error associated with this analytical solution by an impressive two to three orders of magnitude. We propose these empirical correction terms are well suited for use in industrial applications such as process monitoring where analysis speed and accuracy are of the utmost importance.
Tunable reflective dual-band line-to-circular polarization convertor with opposite handedness based on graphene metasurfaces
Authors: Fu Yu , Wang Yueke , Yang Guofeng , Qiao Qi , Liu Yongqi
Published: April 2021

In this letter, we propose a dual-band tunable reflective linear-to-circular (LTC) polarization converter, which is composed of a graphene sheet etched with an I-shaped carved-hollow array. In the mid-infrared region, two LTC bands with opposite handedness are simultaneously realized due to the excitation of the three graphene surface plasmon (GSP) modes. The band of line-to-right-circular-polarization (LTRCP) ranges from 9.87 to 11.03THz with ellipticity χ <−0.95, and from 9.69 to 11.36 THz with an axial ratio of less than 3 dB; the band of line-to-left-circular-polarization (LTLCP) ranges from 13.16 to 14.43THz with χ >0.95, and from 12.79 to 14.61 THz with an axial ratio of less than 3 dB. The tunable responses of the reflective polarizer with Fermi energy (Ef) and electron scattering time (τ) are discussed, and especially the perfect LTLCP can be changed to LTRCP with increasing Ef. Also, the influences of geometric parameters, incident angle, and polarization angle on the performances of the dual-band LTC are also investigated, and it is found that our polarizer converter shows angle insensitivity. All simulation results are conducted by the finite element method. Our design enriches the research of tunable LTC polarizers and has potential applications in integrated terahertz systems.
Dual-frequency optoelectronic oscillator incorporating a single cavity and multiband microwave photonic filter
Authors: Liu Ling , Jin Xian , Ning Tigang , Chen Lawrence R. , Capmany José
Published: April 2021

Dual-frequency optoelectronic oscillators (OEOs) have potential applications in dual-band wireless networking and dual-parameter sensing systems. We propose a dual-frequency OEO incorporating a multiband microwave photonic filter (MPF). In particular, the two microwave signals are generated simultaneously in a single OEO cavity. By simply varying the parameters of optical spectral slicing and sampling (e.g., with a programmable optical filter) used to implement the MPF, we can readily achieve simultaneous tuning of the dual-frequency output, as well as alternate switching between single-frequency and dual-frequency output. The multi-passband nature of the MPF, enabled via optical spectral slicing, opens a path to multi-frequency OEO operation by scaling our scheme in the future. Such a structure provides a flexible way to generate simultaneously tunable and reconfigurable multi-frequency microwave signals.
Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi
Authors: Ibarrola-Vannucci Ana K. , De Pablos Luis M. , Retana-Moreira Lissette , Cornet-Gomez Alberto , Cruz-Bustos Teresa , Schijman Alejandro G. , Ramírez José L. , Vílchez Susana , Osuna Antonio
Published: April 2021

Background

Chagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study ofT.cruziPHBs revealed a pleiotropic function in different stages of the parasite, participating actively in the transformation of the non-infective replicative epimastigote form into metacyclic trypomastigotes and also in the multiplication of intracellular amastigotes.

Methodology/principal findings

To obtain and confirm our results, we applied several tools and techniques such as electron microscopy, immuno-electron microscopy, bioinformatics analysis and molecular biology. We transfectedT.cruziclones with the PHB genes, in order to overexpress the proteins and performed a CRISPR/Cas9 disruption to obtain partially silenced PHB1 parasites or completely silenced PHB2 parasites. The function of these proteins was also studied in the biology of the parasite, specifically in the transformation rate from non-infective forms to the metacyclic infective forms, and in their capacity of intracellular multiplication.

Conclusion/significance

This research expands our understanding of the functions of PHBs in the life cycle of the parasite. It also highlights the protective role of prohibitins against ROS and reveals that the absence of PHB2 has a lethal effect on the parasite, a fact that could support the consideration of this protein as a possible target for therapeutic action.
CaBagE: A Cas9-based Background Elimination strategy for targeted, long-read DNA sequencing
Authors: Wallace Amelia D. , Sasani Thomas A. , Swanier Jordan , Gates Brooke L. , Greenland Jeff , Pedersen Brent S. , Varley Katherine E. , Quinlan Aaron R.
Published: April 2021

A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as Oxford Nanopore’s MinION, enable direct measurement of complex loci without introducing many of the biases inherent to short-read methods, though they suffer from relatively lower throughput. This limitation has motivated recent efforts to develop amplification-free strategies to target and enrich loci of interest for subsequent sequencing with long reads. Here, we present CaBagE, a method for target enrichment that is efficient and useful for sequencing large, structurally complex targets. The CaBagE method leverages the stable binding of Cas9 to its DNA target to protect desired fragments from digestion with exonuclease. Enriched DNA fragments are then sequenced with Oxford Nanopore’s MinION long-read sequencing technology. Enrichment with CaBagE resulted in a median of 116X coverage (range 39–416) of target loci when tested on five genomic targets ranging from 4-20kb in length using healthy donor DNA. Four cancer gene targets were enriched in a single reaction and multiplexed on a single MinION flow cell. We further demonstrate the utility of CaBagE in two ALS patients with C9orf72 short tandem repeat expansions to produce genotype estimates commensurate with genotypes derived from repeat-primed PCR for each individual. With CaBagE there is a physical enrichment of on-target DNA in a given sample prior to sequencing. This feature allows adaptability across sequencing platforms and potential use as an enrichment strategy for applications beyond sequencing. CaBagE is a rapid enrichment method that can illuminate regions of the ‘hidden genome’ underlying human disease.
Design of a multifunction novel flexible fault current limiter for AC distribution network
Authors: Liu Yao , Guan Lin , Tan Zhe , Yang Kun , Guo Fang , Chen Yong , Liu Renliang , Zheng Feng
Published: April 2021

Based on the separation voltage type of cascaded H bridge-modular multilevel converters (CHB-MMC) and current predictive model control (CPMC) technology, a novel flexible fault-current limiter (NFFCL) is firstly proposed for restraining the negative impact of the distribution network’s disturbance in this paper. When a disturbance occurs, the inner-loop CPMC of the multilevel converters establish the value function to offer the specific current, thus increasing the voltage deviation at both ends of the series capacitor or generating reverse harmonic compensation voltage. In that case, three single-phase MNFFCLs can be regarded as variable voltage sources to eliminate the negative effects of faults or harmonics. Owing to the multi-capacitance series structure, the maximum voltage drops of the single capacitance can be predetermined by the number of capacitors. And with the low voltage drop of single capacitance, the output current of the CHB-MMC can also be controlled within an acceptable range. Through the simulation results, the disturbance’s negative impact on the non-fault area can be eliminated almost 100%.
Strike one hundred to educate one: Measuring the efficacy of collective sanctions experimentally
Authors: Chapkovski Philipp
Published: April 2021

In this paper, we test whether sanctions applied to an entire group on account of the free-riding of one of its members can promote group cooperation. To measure the efficiency of such collective sanctions, we conducted a lab experiment based on a standard public good game. The results show that, overall, collective sanctions are ineffective. Moreover, when subjects are able to punish their peers, the level of cooperation is lower in the regime of collective sanctions than under individual sanctions. Both outcomes can be explained by a general disapproval of the collective responsibility for an individual fault: in the post-experimental survey, an absolute majority evaluated such regimes as unfair. While collective sanctions are not an effective means for boosting group compliance, there are nevertheless two insights to be gained here. First, there are differences across genders: under collective sanctions, men’s level of compliance is significantly higher than under individual sanctions, while the opposite is true for women. Second, there were intriguing differences in outcomes between the different regime types. Under collective sanctions, a person who is caught tends to comply in the future, at least in the short term. By contrast, under individual sanctions, an individual wrongdoer decreases his or her level of compliance in the next period.
Association between acoustic speech features and non-severe levels of anxiety and depression symptoms across lifespan
Authors: Albuquerque Luciana , Valente Ana Rita S. , Teixeira António , Figueiredo Daniela , Sa-Couto Pedro , Oliveira Catarina
Published: April 2021

Background

Several studies have investigated the acoustic effects of diagnosed anxiety and depression. Anxiety and depression are not characteristics of the typical aging process, but minimal or mild symptoms can appear and evolve with age. However, the knowledge about the association between speech and anxiety or depression is scarce for minimal/mild symptoms, typical of healthy aging. As longevity and aging are still a new phenomenon worldwide, posing also several clinical challenges, it is important to improve our understanding of non-severe mood symptoms’ impact on acoustic features across lifetime. The purpose of this study was to determine if variations in acoustic measures of voice are associated with non-severe anxiety or depression symptoms in adult population across lifetime.

Methods

Two different speech tasks (reading vowels in disyllabic words and describing a picture) were produced by 112 individuals aged 35-97. To assess anxiety and depression symptoms, the Hospital Anxiety Depression Scale (HADS) was used. The association between the segmental and suprasegmental acoustic parameters and HADS scores were analyzed using the linear multiple regression technique.

Results

The number of participants with presence of anxiety or depression symptoms is low (>7: 26.8% and 10.7%, respectively) and non-severe (HADS-A: 5.4 ± 2.9 and HADS-D: 4.2 ± 2.7, respectively). Adults with higher anxiety symptoms did not present significant relationships associated with the acoustic parameters studied. Adults with increased depressive symptoms presented higher vowel duration, longer total pause duration and short total speech duration. Finally, age presented a positive and significant effect only for depressive symptoms, showing that older participants tend to have more depressive symptoms.

Conclusions

Non-severe depression symptoms can be related to some acoustic parameters and age. Depression symptoms can be explained by acoustic parameters even among individuals without severe symptom levels.
Gamma radiation sterilization of N95 respirators leads to decreased respirator performance
Authors: DeAngelis Haedi E. , Grillet Anne M. , Nemer Martin B. , Wasiolek Maryla A. , Hanson Don J. , Omana Michael A. , Sanchez Andres L. , Vehar David W. , Thelen Paul M.
Published: April 2021

In response to personal protective equipment (PPE) shortages in the United States due to the Coronavirus Disease 2019, two models of N95 respirators were evaluated for reuse after gamma radiation sterilization. Gamma sterilization is attractive for PPE reuse because it can sterilize large quantities of material through hermetically sealed packaging, providing safety and logistic benefits. The Gamma Irradiation Facility at Sandia National Laboratories was used to irradiate N95 filtering facepiece respirators to a sterilization dose of 25 kGy(tissue). Aerosol particle filtration performance testing and electrostatic field measurements were used to determine the efficacy of the respirators after irradiation. Both respirator models exhibited statistically significant decreases in particle filtering efficiencies and electrostatic potential after irradiation. The largest decrease in capture efficiency was 40–50% and peaked near the 200 nm particle size. The key contribution of this effort is correlating the electrostatic potential change of individual filtration layer of the respirator with the decrease filtration efficiency after irradiation. This observation occurred in both variations of N95 respirator that we tested. Electrostatic potential measurement of the filtration layer is a key indicator for predicting filtration efficiency loss.
Applying model approaches in non-model systems: A review and case study on coral cell culture
Authors: Roger Liza M. , Reich Hannah G. , Lawrence Evan , Li Shuaifeng , Vizgaudis Whitney , Brenner Nathan , Kumar Lokender , Klein-Seetharaman Judith , Yang Jinkyu , Putnam Hollie M. , Lewinski Nastassja A.
Published: April 2021

Model systems approaches search for commonality in patterns underlying biological diversity and complexity led by common evolutionary paths. The success of the approach does not rest on the species chosen but on the scalability of the model and methods used to develop the model and engage research. Fine-tuning approaches to improve coral cell cultures will provide a robust platform for studying symbiosis breakdown, the calcification mechanism and its disruption, protein interactions, micronutrient transport/exchange, and the toxicity of nanoparticles, among other key biological aspects, with the added advantage of minimizing the ethical conundrum of repeated testing on ecologically threatened organisms. The work presented here aimed to lay the foundation towards development of effective methods to sort and culture reef-building coral cells with the ultimate goal of obtaining immortal cell lines for the study of bleaching, disease and toxicity at the cellular and polyp levels. To achieve this objective, the team conducted a thorough review and tested the available methods (i.e. cell dissociation, isolation, sorting, attachment and proliferation). The most effective and reproducible techniques were combined to consolidate culture methods and generate uncontaminated coral cell cultures for ~7 days (10 days maximum). The tests were conducted on scleractinian corals Pocillopora acuta of the same genotype to harmonize results and reduce variation linked to genetic diversity. The development of cell separation and identification methods in conjunction with further investigations into coral cell-type specific metabolic requirements will allow us to tailor growth media for optimized monocultures as a tool for studying essential reef-building coral traits such as symbiosis, wound healing and calcification at multiple scales.
Development of a graph convolutional neural network model for efficient prediction of protein-ligand binding affinities
Authors: Son Jeongtae , Kim Dongsup
Published: April 2021

Prediction of protein-ligand interactions is a critical step during the initial phase of drug discovery. We propose a novel deep-learning-based prediction model based on a graph convolutional neural network, named GraphBAR, for protein-ligand binding affinity. Graph convolutional neural networks reduce the computational time and resources that are normally required by the traditional convolutional neural network models. In this technique, the structure of a protein-ligand complex is represented as a graph of multiple adjacency matrices whose entries are affected by distances, and a feature matrix that describes the molecular properties of the atoms. We evaluated the predictive power of GraphBAR for protein-ligand binding affinities by using PDBbind datasets and proved the efficiency of the graph convolution. Given the computational efficiency of graph convolutional neural networks, we also performed data augmentation to improve the model performance. We found that data augmentation with docking simulation data could improve the prediction accuracy although the improvement seems not to be significant. The high prediction performance and speed of GraphBAR suggest that such networks can serve as valuable tools in drug discovery.
Mining heterogeneous clinical notes by multi-modal latent topic model
Authors: Wen Zhi , Nair Pratheeksha , Deng Chih-Ying , Lu Xing Han , Moseley Edward , George Naomi , Lindvall Charlotta , Li Yue
Published: April 2021

Latent knowledge can be extracted from the electronic notes that are recorded during patient encounters with the health system. Using these clinical notes to decipher a patient’s underlying comorbidites, symptom burdens, and treatment courses is an ongoing challenge. Latent topic model as an efficient Bayesian method can be used to model each patient’s clinical notes as “documents” and the words in the notes as “tokens”. However, standard latent topic models assume that all of the notes follow the same topic distribution, regardless of the type of note or the domain expertise of the author (such as doctors or nurses). We propose a novel application of latent topic modeling, using multi-note topic model (MNTM) to jointly infer distinct topic distributions of notes of different types. We applied our model to clinical notes from the MIMIC-III dataset to infer distinct topic distributions over the physician and nursing note types. Based on manual assessments made by clinicians, we observed a significant improvement in topic interpretability using MNTM modeling over the baseline single-note topic models that ignore the note types. Moreover, our MNTM model led to a significantly higher prediction accuracy for prolonged mechanical ventilation and mortality using only the first 48 hours of patient data. By correlating the patients’ topic mixture with hospital mortality and prolonged mechanical ventilation, we identified several diagnostic topics that are associated with poor outcomes. Because of its elegant and intuitive formation, we envision a broad application of our approach in mining multi-modality text-based healthcare information that goes beyond clinical notes. Code available at https://github.com/li-lab-mcgill/heterogeneous_ehr.
Evaluation of the performance of health extension workers on malaria rapid diagnostic tests and predictor factors in Bahir Dar Zuria district, northwest Ethiopia: A cross-sectional study
Authors: Dejazmach Zelalem , Alemu Getaneh , Yimer Mulat , Muluneh Chalachew , Tegegne Banchamlak
Published: April 2021

Background

In Ethiopia, anti-malaria treatment is initiated after parasitological confirmation using blood film microscopy at health centers and hospitals, or serological rapid diagnostic tests at health posts. At health posts, the diagnosis is performed by health extension workers using rapid diagnostic tests after little training. However, there is paucity of data about the health extension workers’ performance on rapid diagnostic tests. Hence, periodic monitoring of the performances of health extension workers on malaria rapid diagnostic tests and predicted factors plays a pivotal role for the control of malaria.

Methods

A cross sectional study was conducted in May 2020, among 75 health extension workers working at health posts in Bahir Dar Zuria district, Northwest Ethiopia. Their performance on malaria rapid diagnostic tests was assessed by distributing known positive and negative samples as confirmed by investigators using both rapid diagnostic test and blood film microscopy. Test results from health extension workers were then compared with that of investigators. Procedural errors committed while performing the tests were assessed using observational checklist. Data were analyzed using SPSS software version 20.

Results

The overall sensitivity and specificity of health extension workers in detecting Plasmodium species were 96.8% and 98.7%, respectively with 97.3% result agreement between the health extension workers and investigators (kappa value = 0.949). The most common procedural errors committed by health extension workers was ‘not checking expiry date of the test kits’ followed by ‘not adhering to the appropriate time of reading results’ that 70.7% and 64% of the participants committed these errors, respectively. Total number of procedural errors committed by those who have got in-service training was decreased by 47.3% as compared to those without in-service training.

Conclusions

Health extension workers had high performance on malaria rapid diagnostic tests. However, in-service training and periodic supervision should be given in order to maximize performance on these tests.
Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka
Authors: Hewage Sumudu , Somasundaram Noel , Ratnasamy Vithiya , Ranathunga Ishara , Fernando Amitha , Perera Indika , Perera Udara , Vidanagama Dhammika , Cader Mizaya , Fernando Poorna , Pallewatte Nirupa , Rathnayaka Lakmal , Jayawardhana Dushani , Danansuriya Manjula , Gunawardena Nalika
Published: April 2021

End TB strategy by the WHO suggest active screening of high-risk populations for tuberculosis (TB) to improve case detection. Present study generates evidence for the effectiveness of screening patients with diabetes mellitus (DM) for Pulmonary TB (PTB). A study was conducted among 4548 systematically recruited patients over 45 years attending DM clinic at the National Hospital of Sri Lanka. The study units followed an algorithm specifying TB symptom and risk factor screening for all, followed by investigations and clinical assessments for those indicated. Bacteriologically confirmed or clinically diagnosed PTB were presented as proportions with 95% CI. Mean (SD) age was 62·5 (29·1) years. Among patients who completed all indicated steps of algorithm, 3500 (76·9%) were investigated and 127 (2·8%) underwent clinical assessment. Proportion of bacteriologically confirmed PTB patients was 0·1% (n = 6,95%CI = 0·0–0·3%). None were detected clinically. Analysis revealed PTB detection rates among males aged ≥60 years with HbA1c ≥ 8 to be 0·4% (n = 2, 95%CI = 0·0–1·4%). The study concludes that active screening for PTB among all DM patients at clinic settings in Sri Lanka, to be non-effective measure to enhance TB case finding. However, the sub-category of diabetic males with uncontrolled diabetics who are over 60 years of age is recommended as an option to consider for active screening for PTB.
Effects of changes in regular physical activity status on hip fracture: A nationwide population-based cohort study in Korea
Authors: Han Sangsoo , Jang Hae-Dong , Nah Sangun , Han Kyungdo , Lim Hyunwoong , Kim Won Seok , Hong Jae-Young
Published: April 2021

Objective

Hip fracture incidence is increasing with rapid aging of the population and regular physical activity (RPA) is an important modifiable protective factor for fracture. However, the association between the risk of hip fractures and changes in RPA status in the general population remains unknown. Thus, we explore the association between the risk of hip fracture and changes in RPA status.

Methods

We studied 4,984,144 individuals without fractures within a year whose data were registered in the Korean National Health Insurance Service database. Baseline physical activity level was assessed using a standardized self-reported questionnaire during two consecutive national health screening surveys performed in Korea from 2009 to 2012. The risk of hip fracture between 2013 and 2016 according to change in RPA was prospectively analyzed. Participants were divided into those who were always inactive, became inactive, became active, and were always active.

Results

Compared to participants who were always inactive, those who became inactive exhibited a 0.12/1,000 person-years (PY) reduction in hip fracture incidence rate (IR) [aHR: 0.865; 95% confidence interval (CI): 0.824–0.908]. Participants who became active, and those who were always active, exhibited a 0.24/1,000 PY reduction in IR (aHR: 0.827; 95% CI: 0.787–0.870) and a 0.39/1,000 PY reduction in IR (aHR: 0.691; 95% CI: 0.646–0.740), respectively.

Conclusion

Changes in RPA status were associated with the risk of hip fracture; consistent RPA was related to the maximum benefit for risk reduction in the general population.
Sex-differences in circulating biomarkers during acute myocardial infarction: An analysis from the SWEDEHEART registry
Authors: Eggers Kai M. , Lindhagen Lars , Baron Tomasz , Erlinge David , Hjort Marcus , Jernberg Tomas , Johnston Nina , Marko-Varga György , Rezeli Melinda , Spaak Jonas , Lindahl Bertil
Published: April 2021

Background

Sex-differences in the pathobiology of myocardial infarction are well established but incompletely understood. Improved knowledge on this topic may help clinicians to improve management of men and women with myocardial infarction.

Methods

In this registry-based cohort study (SWEDEHEART), we analyzed 175 circulating biomarkers reflecting various pathobiological axes in 856 men and 243 women admitted to Swedish coronary care units because of myocardial infarction. Two multimarker panels were applied (Proximity Extension Assay [Olink Bioscience], Multiple Reaction Monitoring mass spectrometry). Lasso analysis (penalized logistic regression), multiple testing-corrected Mann-Whitney tests and Cox regressions were used to assess sex-differences in the concentrations of these biomarkers and their implications on all-cause mortality and major adverse events (median follow-up up to 6.6 years).

Results

Biomarkers provided a very high discrimination between both sexes, when considered simultaneously (c-statistics 0.972). Compared to women, men had higher concentrations of six biomarkers with the most pronounced differences seen for those reflecting atherogenesis, myocardial necrosis and metabolism. Women had higher concentrations of 14 biomarkers with the most pronounced differences seen for those reflecting activation of the renin-angiotensin-aldosterone axis, inflammation and for adipokines. There were no major variations between sexes in the associations of these biomarkers with outcome.

Conclusions

Severable sex-differences exist in the expression of biomarkers in patients with myocardial infarction. While these differences had no impact on outcome, our data suggest the presence of various sex-related pathways involved in the development of coronary atherosclerosis, the progression to plaque rupture and acute myocardial damage, with a greater heterogeneity in women.
Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
Authors: Thi Bui Dieu Huyen , Nguyen Bai Xuan , Truong Dat Cong , Meyrowitsch Dan Wolf , Søndergaard Jens , Gammeltoft Tine , Bygbjerg Ib Christian , Jannie Nielsen
Published: April 2021

Objectives

People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam.

Method

People with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress.

Results

Of the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (<1–5 years OR = 1.66; 95%CI: 1.09–2.53 and >5 years OR = 1.74; 95%CI: 1.14–2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1–2 comorbidities: OR = 2.0; 95%CI: 1.18–3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50–4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11–2.01) as compared to those without distress.

Conclusions

In rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements.
Aquatic invasive alien rodents in Western France: Where do we stand today after decades of control?
Authors: Bonnet Manon , Guédon Gérald , Pondaven Marc , Bertolino Sandro , Padiolleau Damien , Pénisson Vanessa , Gastinel Francine , Angot Fabien , Renaud Pierre-Cyril , Frémy Antonin , Pays Olivier
Published: April 2021

Two aquatic invasive alien rodents, the coypu (Myocastor coypus) and muskrat (Ondatra zibethicus), have taken over a significant amount of wetlands in France. Pays de la Loire is an administrative region of about 32 000 km2 in the Western France with 6.3% of its area in wetlands (excluding the Loire River). Populations of coypus and muskrats are established and a permanent control programme has been set to reduce their impacts. The control plan is based on few professional trappers and many volunteers which makes this programme unique compared to other programme relying on professionals only. The aim of this study is to analyse the temporal and spatial dynamics of coypu and muskrat captures during the last 10 years to evaluate their effectiveness. The number of rodents removed per year increased by 50% in 10 years and reached about 288 000 individuals in 2016 with about 80% of them being coypus. During the same time length, the number of trappers involved in the programme also increased by 50% to reach 3 000 people in 2016. Although the raise of coypus and muskrats trapped can possibly be explained by an increase of the number of trappers, the number of coypus removed per trapper per year increased by 22%. Despite the outstanding number of individuals removed per year, our results suggest that the programme does not limit the population dynamics of coypus. Finally, since 2017, the number of data gathered from municipalities decreased, as did the total number of individuals trapped. Indeed, although rewards are crucial to recruit new volunteers, subsidies from local and regional authorities are declining. Decision makers and financers should be encouraged to fund this programme from the perspectives of the direct or indirect costs related to the presence of aquatic invasive alien rodents in wetlands.
Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques
Authors: Sabater-Cruz Noelia , Figueras-Roca Marc , Padró-Pitarch Lydia , Tort Jaume , Casaroli-Marano Ricardo P.
Published: April 2021

Purpose

To report corneal transplant activity carried out in Catalonia (Spain) and the evolving indications for keratoplasty over an 8-year period.

Methods

Annual reports from the Catalan Transplant Organization, Spain, on corneal graft indications and techniques from 2011 to 2018 were reviewed.

Results

A total of 9457 keratoplasties were performed in Catalonia, from January 2011 to December 2018. The most frequent indications were bullous keratopathy (BK; 20.5%), Fuchs endothelial dystrophy (FED; 17.9%), re-graft (13.7%), and keratoconus (11.3%). Penetrating keratoplasty (PKP) accounted for 63.4% of all performed keratoplasties. Since the introduction of eye bank precut tissue for Descemet stripping automated endothelial keratoplasty (DSAEK) in 2013 and for Descemet membrane endothelial keratoplasty (DMEK) in 2017 the number of endothelial keratoplasties has drastically increased. An increasing trend of posterior lamellar techniques over the total of keratoplasties was found (p<0.001). Endothelial keratoplasties for different endothelial diseases indications (BK, FED, and re-graft), also showed and increasing trend (p<0.001). DMEK is the technique with the highest increase (statistically significantly different from linearity) over other endothelial keratoplasties in FED (p<0.001) but not in BK (p = 0.67) or re-grafts (p = 0.067).

Conclusion

Endothelial diseases represented the top indication for keratoplasty over the 8-year period. PKP is still the most used technique in Catalonia, but endothelial keratoplasties and especially DMEK showed a significant increasing trend over the last years. This is congruent with the main rationale nowadays for keratoplasties: to customize and transplant as less tissue as possible. Therefore, the availability of precut tissue could have definitely enforced such approach.
A computational lens into how music characterizes genre in film
Authors: Ma Benjamin , Greer Timothy , Knox Dillon , Narayanan Shrikanth
Published: April 2021

Film music varies tremendously across genre in order to bring about different responses in an audience. For instance, composers may evoke passion in a romantic scene with lush string passages or inspire fear throughout horror films with inharmonious drones. This study investigates such phenomena through a quantitative evaluation of music that is associated with different film genres. We construct supervised neural network models with various pooling mechanisms to predict a film’s genre from its soundtrack. We use these models to compare handcrafted music information retrieval (MIR) features against VGGish audio embedding features, finding similar performance with the top-performing architectures. We examine the best-performing MIR feature model through permutation feature importance (PFI), determining that mel-frequency cepstral coefficient (MFCC) and tonal features are most indicative of musical differences between genres. We investigate the interaction between musical and visual features with a cross-modal analysis, and do not find compelling evidence that music characteristic of a certain genre implies low-level visual features associated with that genre. Furthermore, we provide software code to replicate this study athttps://github.com/usc-sail/mica-music-in-media. This work adds to our understanding of music’s use in multi-modal contexts and offers the potential for future inquiry into human affective experiences.
Community-based conservation with formal protection provides large collateral benefits to Amazonian migratory waterbirds
Authors: Campos-Silva João Vitor , Peres Carlos A. , Hawes Joseph E. , Abrahams Mark I. , Andrade Paulo C. M. , Davenport Lisa
Published: April 2021

Populations of migratory waterbirds are facing dramatic declines worldwide due to illegal hunting, habitat loss and climate change. Conservation strategies to reverse these trends are imperative, especially in tropical developing countries, which almost invariably allocate insufficient levels of investment for environmental protection. Here, we compared the effectiveness of sustainable-use Protected Areas (PAs) and Community-based Conservation (CBC) arrangements for the conservation of migratory waterbirds that breed on seasonal riverine sandy beaches in Brazilian Amazonia. We modeled local population responses of four migratory waterbird species on 155 beaches along a ~1,600 km section of a major tributary of the Amazon, as a function of community enforcement, official protection status, human pressure and landscape features. We show that 21 community-protected beaches within the study area host more than 80% of all sampled birds. Black Skimmers showed the most dramatic response, with breeding numbers 135-fold larger in CBC arrangements compared to beaches with no official protection status. The same pattern was observed for nesting Large-Billed and Yellow-Billed Terns. For the Near Threatened Orinoco Goose, PA status was the strongest predictor of local population size. These dramatic results demonstrate the value of protected refugia, achieved through the concerted action of participating local communities, to support breeding populations of key waterbird species. This highly-effective and low-cost conservation model can potentially be replicated in other regions of the developing world experiencing increasingly intensive exploitation of riverine natural resources.
A vezetés-szervezés diszciplína nagyjai: Susánszky János, Kovács Sándor, Ladó László
Authors: Barakonyi Károly , Bakacsi Gyula , Balaton Károly , Dobák Miklós , Erdősi Gyula , Szintay István
Published: April 2021

Az MTA Vezetés- és Szervezéstudományi Bizottsága 2007. március 9-én emlékülést szervezett a vezetésszervezés diszciplína hazai nagyjai emlékére. Az emlékülés visszaemlékezéseit, méltatásait a szerzők egy cikksorozatban örökítették meg. A Vezetéstudomány márciusi számában Szabó Lászlóról, Harsányi Istvánról és Máriás Antalról olvashattak, most pedig Susánszky Jánosra, Kovács Sándorra és a közelmúltban elhunyt Ladó Lászlóra emlékeznek a szerzők.
Multiparadigmatikus megközelítés válasza a paradigmavitára
Authors: Primecz Henriett
Published: April 2021

A cikk azt az elméleti kérdést vizsgálja, hogy a szervezetelméletek területén definiált paradigmák milyen viszonyban állnak egymással, és a szakirodalomban elterjedt összeegyeztethetőségi vitának milyen perspektívái léteznek. A szerző szerint erre a vitára leginkább a multiparadigmatikus megközelítés ad választ. Ugyanakkor kiemeli a szerző, hogy a multiparadigmatikus megközelítés nem tagadja az összeegyeztethetőségi vitát, nem integrálja vagy keveri a paradigmákat. A multiparadigmatikus megközelítésnek több fajtáját mutatja be a cikk: a zárójelbe tételt, a zárójelbe tételt és hídverést, a hídverést, a párhuzamos és szekvenciális kutatást, metaelmélet-építést és az interplayt.
A beosztás és a nemek hatása a változások érzékelésére egy lean projekt tapasztalatai egy magyar autóipari beszállítónál (Efficient possibilities of the customer complaints: compensation and apology)
Authors: Demeter Krisztina , Losonci Dávid , Jenei István
Published: April 2021

Tanulmányukban a szerzők egy magyar tulajdonú autóipari beszállító lean (továbbiakban karcsú) átalakulását vizsgáljuk. Bár az új rendszer bevezetése alig több mint egy éve kezdődött el a vállalatnál, mégis a rövid idő ellenére komoly eredményekről számolhatnak be. Különösen látványos a pénzügyi mutatók és a vevői elégedettség területén elért javulás. Kutatásuk célja kettős volt: (1) megvizsgálni, hogyan érzékelik a vezetők és a beosztottak a változásokat, valamint (2) összehasonlítani a vállalat két üzemében dolgozó nők és férfiak átalakítással kapcsolatos reakcióit és érzeteit. Az eredmények alapján elmondható, hogy a vezetők és a beosztottak, csakúgy, mint a két nem képviselői, nagyon eltérően gondolkodnak a változásokról és az átalakítás sikerének hátteréről. Eredményeik tükrében megállapítható, hogy a vizsgált szervezetnél a női munkavállalóknál a hit, a férfiaknál az elkötelezettség az a tényező, amely leginkább hatással van a sikerérzetre. A kutatás tapasztalatait felhasználva tanácsokat fogalmaznak meg a karcsú menedzsment sikeres bevezetésével kapcsolatosan. ______________ Relatively little research attention has been given to what happens after service failure, how the organizations respond to the failure and how this response affects customers’ subsequent behaviours and attitudes. This article proposes to take an in-depth look at the different organizational responses to customer complaints. On the basis of the equity theory the concept of justice has been used that involves distributive, procedural and interactional justice. Using 2x2x2 factorial design experiment based on scenarios the main findings of the research is that interactional justice (explanation and apology) is as important as distributive justice (compensation). On the other hand the result is dependent on the failure type: different recovery effort is efficient in the case of outcome or process failure.
Quaternary Geology of the Indiana Portion of the Eastern Extent of the South Bend 30- x 60-Minute Quadrangle
Authors: Antinao Jose Luis , Rupp Robin
Published: April 2021

The Quaternary Geology of the eastern South Bend 30- x 60-Minute Quadrangle in Indiana represents landforms and near-surface sediments deposited during the Wisconsin Episode, Late Pleistocene. Sediments and landforms reflect the interplay between the Saginaw and Michigan Lobes of the Laurentide Ice Sheet. A relatively shallow, buried pre-Wisconsin and mid-Wisconsin morphology has been overridden by advances leading to the Last Glacial Maximum (LGM), ca. 24 ka. Between 24 and 17 ka, retreating ice fronts from the Michigan Lobe left a succession of ice-contact sediment ramps and associated pitted and collapsed fan-moraine complexes throughout the south and west of the map area. A sequence of stacked diamicton and sand and gravel fan heads appears at the hinged interlobate area north and northeast of South Bend. Ice margin positions are marked by distinct features like fans, kames and ice-walled lake plains, which are well developed on Michigan Lobe margins. The thicker glaciofluvial sand and gravel packages appear mostly interbedded with diamicton beds along fan heads, with relatively minor deposits in valley train units. Lowlands are mostly occupied by post-LGM (ca. 18 ka) valley-train outwash deposits, with interpreted flow toward the south and west, derived from an ice margin retreating first from south to north, near Mishawaka, then from southeast to northwest across the Kankakee valley. Sand and gravel colluvial and alluvial fans developed in a short span after ice retreated, along with incision of the ice-sculpted morphology. Late-glacial aeolian sand dunes sealed the landscape. Relatively minor modification of the landscape during the Holocene is indicated by alluvial and palustrine deposits.
Bedrock Topography of the Berne, Domestic, Geneva, and Willshire 7.5-Minute Quadrangles, Indiana-Ohio
Authors: Rupp Robin R. , Tripp Donald C. , Loope Henry M. , Antinao Jose Luis , Johnson Matthew R. , Nash Thomas A. , Norris Tyler A.
Published: April 2021

This map provides updated bedrock topography for the eastern extent of the Lafayette Bedrock Valley System in Indiana.