bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric Preventive Care in Middle-High Resource Countries—The Padova Chart for Health in Children
Authors: Galderisi Alfonso , Perilongo Giorgio , Caprio Sonia , Da Dalt Liviana , Di Salvo Giovanni , Gatta Michela , Giaquinto Carlo , Rizzuto Rosario , Robb Adelaide , Sly Peter David , Simonelli Alessandra , Staiano Annamaria , Vettor Roberto , Baraldi Eugenio
Published: April 2022

Importance

The Padova Chart for Health in Children (PCHC) aims to gather the evidence of healthcare promotion and protection for chidren and adolescents (i.e., aged <18 y) into a single document in order to guide families, healthcare providers and social actors on healthy choices. No more than 2% of Europeans and North Americans aged <30 y have a healthy lifestyle. This, together with metabolic and brain plasticity during childhood, creates the ideal opportunity to implement preventive strategies. Guided interventions promoting healthy lifestyle in children and families therefore have a key role in abating the unprecedented pandemic of non-communicable diseases (NCDs) in adulthood.

Observations

The PCHC is divided into four sections: nutrition, cardiovascular health, respiratory health, and mental and social health. Each section is structured in an ALICE approach (assessment, lobbying, intervention, call-for-action, evaluation): assessment of necessity, describing relevance to healthcare; lobbying to identify those who can effect the proposed interventions; interventions involving family, school and peers; a call-for-action to define priorities among the proposed interventions; and objective evaluation measures that can be applied on a population basis.

Conclusions and Relevance

Interventions promoting health in childhood require joint action from multiple institutional, local and family representatives, with the shared goal of promoting health across the entire age group. These lifestyle interventions have the potential to change the lifetime risk trajectory for NCDs.
NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities
Authors: Zhang Fang , Amat Gulbanur , Tang Yanjing , Chen Ru , Tian Xin , Hu Wenting , Chen Changcheng , Shen Shuhong , Xie Yangyang
Published: April 2022

Background

Thiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression. The nudix hydrolase 15 (NUDT15) genetic polymorphism is strongly associated with the tolerance and myelosuppressive effect of mercaptopurine administration, but the frequency of NUDT15 variants is known to vary among different ethnic groups or nationalities. At present, the NUDT15 gene polymorphism in ethnic minorities such as the Uighur, Kirghiz, and Dai nationalities in China is unclear.

Procedure

DNA samples were isolated from 1,071 Chinese children, including 675 Han children with acute lymphoblastic leukemia and 396 healthy minority children, including 118 Uighur, 126 Kirghiz, and 152 Dai participants. The coding regions of NUDT15 exons 1 to 3 were amplified by polymerase chain reaction. NUDT15 genotypes were identified by Sanger sequencing.

Results

Five NUDT15 genetic variants of coding regions including rs746071566 (c.55_56insGAGTCG), rs186364861 (c.52G > A), c.137C > G, and c.138T > G in exon 1, and the variant rs116855232 (c.415C > T) in exon 3 were found among the participants. The frequency of NUDT15 rs746071566 variants was lower in the Uighur and Kirghiz populations than in the Han population and in other East Asian nationalities, while the frequency of c.415C > T variants was lower in the Dai population. The c.52G > A variant was relatively uncommon in children of the Han, Uighur, Kirghiz, and Dai ethnic groups. Notably, the rare variants c.137C > G and c.138T > G in a Uighur child were predicted to be disruptive sites.

Conclusion

In summary, our results illustrate the NUDT15 polymorphisms in Chinese children of Han, Uighur, Kirghiz, and Dai nationalities, and provide the most effective detection recommendations for different ethnic groups to predict thiopurine-related toxicity, which could be used to guide future clinical thiopurine dose adjustment.
What Is Teamwork? A Mixed Methods Study on the Perception of Teamwork in a Specialized Neonatal Resuscitation Team
Authors: Ediger Krystyna , Rashid Marghalara , Law Brenda Hiu Yan
Published: April 2022

Introduction

Neonatal resuscitation is a team-based activity involving many decisions and tasks. Non-technical factors, such as teamwork, are increasingly recognized as impacting how well-neonatal resuscitation is performed, and therefore influencing infant outcomes. Prior studies on teamwork in neonatal resuscitation have focused on quantification of teamwork behaviors, or the effects of team training. This study aimed to explore healthcare providers' own perception of teamwork in this specialized environment to identify perceived barriers and facilitators to effective team functioning.

Methods

This single-center exploratory sequential mixed methods study used two phases. First, semi-structured interviews were conducted, and thematic analysis used to identify themes. Subsequently, interview data informed the development of quantitative surveys to explore selected themes in the wider team.

Results

From ten semi-structured interviews, seven themes were identified including: (1) Team Composition, (2) Effective Communication, (3) Team leadership, (4) Hierarchy, (5) Team Training, (6) Debriefing, and (7) Physical Environment. Perceived teamwork facilitators include role assignment, familiarity, team composition, talking out loud to maintain shared mental models, leadership, and team training. Perceived barriers included time pressures, ad hoc team, ineffective leadership, and space limitations. Selected themes (Communication, Speaking up, Hierarchy, and Leadership) were further explored via electronic surveys distributed via email to all members of the resuscitation team. There were 105 responses; a response rate of ~53%. All respondents agreed or strongly agreed that speaking up is important; however, not all felt comfortable doing so. Neonatal fellows (14%) and nurses (12%) were most likely to report not feeling comfortable speaking up. All respondents agreed that team communication is important to an effective resuscitation. Most respondents (91.5%) agreed that a hierarchy exists within the team; 54.3% believed that hierarchy positively contributes to effective resuscitation. All respondents agreed or strongly agreed that having a clearly defined leader is important in delivery room resuscitations. Ineffective leadership was the most cited reason for poor team communication.

Conclusions

In this mixed methods study of perceptions of teamwork within a specialized, multi-disciplinary neonatal resuscitation team, communication, hierarchy, and leadership were positively perceived and facilitates teamwork. However, even in this environment, some nurses and trainees expressed discomfort with speaking up.
Epigallocatechin-3-Gallate Delivery in Lipid-Based Nanoparticles: Potentiality and Perspectives for Future Applications in Cancer Chemoprevention and Therapy
Authors: Farabegoli Fulvia , Pinheiro Marina
Published: April 2022

Chemoprevention is a strategy aimed to not only reduce the risk but also delay the development or recurrence of cancer. An ideal chemopreventive agent is not dangerous and ought not to result in side effects or damage to human health. In this context, epigallocatechin-3-gallate (EGCG) is considered a suitable chemopreventive agent, but its clinical use is limited by many factors, namely, the difference in source, administration, individual metabolism, absorption, and distribution. Genetic and dietary differences greatly cause this variability, which has limited the rational use of EGCG in chemoprevention and, particularly, the definition of a safe and efficient concentration. In the present mini review, the main limitations to a complete understanding of the use of EGCG as a chemopreventive agent will be briefly illustrated. This review also indicates the introduction and trialing of lipid-based nanoparticles (NPs) as a proper strategy to deliver EGCG at a well-defined concentration for better investigation of the chemopreventive activity. Finally, some examples of cancers that might benefit from EGCG treatment in different stages of the disease are proposed.
Magnetic Nozzle and RPA Simulations vs. Experiments for a Helicon Plasma Thruster Plume
Authors: Cichocki Filippo , Navarro-Cavallé Jaume , Modesti Alberto , Ramírez Vázquez Gonzalo
Published: April 2022

The experimental characterization of electrodeless plasma thrusters with a magnetic nozzle is fundamental in the process of increasing their maturity to reach the industrialization level. Moreover, it offers the unique opportunity of validating existing numerical models for the expansion of a magnetized plasma plume, and for the synthetic simulation of diagnostics measurements, like those of a retarding potential analyzer, which provides essential information regarding the ion beam energy distribution function. Simulations to experiments comparison ultimately enables a better understanding of the physical processes behind the observed experimental curves. In this work, input experimental data of a Helicon plasma plume is used to simulate both a magnetic nozzle expansion in the divergent field region, and the corresponding measurements of a retarding potential analyzer, through dedicated small-scale simulations of this diagnostics tool. Magnetic nozzle simulation and experimental results agree well in terms of the angular distribution of the ion current at 40 cm distance from the source, and also in the prediction of the energies of the two main peaks of the ion energy distribution function: a first one at 45 eV due to source ions, and a second one, at 15–20 eV, due to ions from charge-exchange and ionization collisions in the plume. Finally, the small-scale simulation of the retarding potential analyzer permits to assess the parasitic effects caused by the ion current collected by the different analyzer grids. The inclusion of the retarding and electron suppression grids currents in the overall I-V characteristic is shown to correct almost entirely these effects on the obtained ion velocity distribution.
Automatic Multichannel Electrocardiogram Record Classification Using XGBoost Fusion Model
Authors: Ye Xiaohong , Huang Yuanqi , Lu Qiang
Published: April 2022

There is an increasing demand for automatic classification of standard 12-lead electrocardiogram signals in the medical field. Considering that different channels and temporal segments of a feature map extracted from the 12-lead electrocardiogram record contribute differently to cardiac arrhythmia detection, and to the classification performance, we propose a 12-lead electrocardiogram signal automatic classification model based on model fusion (CBi-DF-XGBoost) to focus on representative features along both the spatial and temporal axes. The algorithm extracts local features through a convolutional neural network and then extracts temporal features through bi-directional long short-term memory. Finally, eXtreme Gradient Boosting (XGBoost) is used to fuse the 12-lead models and domain-specific features to obtain the classification results. The 5-fold cross-validation results show that in classifying nine categories of electrocardiogram signals, the macro-average accuracy of the fusion model is 0.968, the macro-average recall rate is 0.814, the macro-average precision is 0.857, the macro-average F1 score is 0.825, and the micro-average area under the curve is 0.919. Similar experiments with some common network structures and other advanced electrocardiogram classification algorithms show that the proposed model performs favourably against other counterparts in F1 score. We also conducted ablation studies to verify the effect of the complementary information from the 12 leads and the auxiliary information of domain-specific features on the classification performance of the model. We demonstrated the feasibility and effectiveness of the XGBoost-based fusion model to classify 12-lead electrocardiogram records into nine common heart rhythms. These findings may have clinical importance for the early diagnosis of arrhythmia and incite further research. In addition, the proposed multichannel feature fusion algorithm can be applied to other similar physiological signal analyses and processing.
Identification and Validation of Quantitative Trait Loci for Wheat Dwarf Virus Resistance in Wheat (Triticum spp.)
Authors: Pfrieme Anne-Kathrin , Ruckwied Britta , Habekuß Antje , Will Torsten , Stahl Andreas , Pillen Klaus , Ordon Frank
Published: April 2022

Wheat dwarf virus (WDV) is transmitted by the leafhopper Psammotettix alienus. As a major pathogen in wheat and other cereals, WDV causes high yield losses in many European countries. Due to climate change, insect-transmitted viruses will become more important and the restrictions in the use of insecticides efficient against P. alienus renders growing of WDV resistant/tolerant varieties the only effective strategy to control WDV. So far, there is little information about the possible sources of resistance and no known information about the genome regions responsible for the resistance. In a screening for WDV resistance using artificial inoculation in gauze houses, a panel of 500 wheat accessions including cultivars, gene bank accessions, and wild relatives of wheat was phenotyped for virus titer, infection rate, as well as plant height and yield parameters relative to healthy controls of the same genotype. Additionally, 85 T. aestivum-Ae. tauschii intogression lines were tested for WDV resistance in the greenhouse. A subset of 250 hexaploid wheat accessions was genotyped with the 15k iSelect SNP Chip. By genome-wide association study (GWAS), the quantitative trait loci (QTL) for partial WDV resistance were identified. Within these studies, one cultivar was identified showing an average infection rate of only 5.7%. By analyzing single seed descent (SSD) and doubled haploid (DH) populations comprising 153 and 314 individuals for WDV resistance and by genotyping these with the 25k iSelect SNP Chip, QTL for yield per plant, thousand-grain weight, and relative virus titer were validated on chromosomes 1B, 2B, 3B, 4B, 4A, 5A, 6A, and 7A. These results will be the basis for marker-assisted selection for WDV resistance to replacing the laborious, time-consuming, and technically challenging phenotyping with WDV bearing leafhoppers.
Exploring the Nature of Teachers’ Math-Gender Stereotypes: The Math-Gender Misconception Questionnaire
Authors: Dersch Anna-Sophia , Heyder Anke , Eitel Alexander
Published: April 2022

Stereotypes of girls having weaker mathematical abilities than boys (math-gender stereotypes) are one factor reducing women’s representation in mathematics. Teachers, as powerful socializers, often hold math-gender stereotypes. Reducing math-gender stereotypes in (student) teachers thus may foster women’s representation in mathematics. Yet knowing the stereotypes’ underlying assumptions is crucial to reducing it. Do math-gender stereotypes reflect elaborate, disproven theories about gender differences in math, meaning math-gender misconceptions? And if so, which math-gender misconceptions are behind math-gender stereotypes? This is the focus of the present research. The relevant literature implies the existence of three distinct misconceptions: (1) empathizing-systemizing (“As girls think rather empathically and boys think rather systematically, boys are on average more talented in math than girls”), (2) girls’ compensation (“To achieve equally good grades in mathematics, boys have to make less effort because they are more talented than girls are”), and (3) girls’ non-compensability (“Despite their on average stronger effort, girls are normally less proficient in math than boys”). We assessed these misconceptions in a student teacher sample (N = 303) using our newly developed Math-Gender Misconceptions Questionnaire. Our results offer support for the expected three-factor structure of math-gender misconceptions. All three math-gender misconceptions showed good to acceptable scale reliabilities. On average, preservice teachers did not hold (strong) math-gender misconceptions. But a subgroup of 48.2% of preservice teachers held at least one of the three misconceptions. The empathizing-systemizing misconception was the most prevalent (32.0%) among the three misconceptions. Descriptively, endorsing the math-gender stereotype correlated most strongly with the empathizing-systemizing (r = 0.43) and the girls’ compensation misconception (r = 0.44). This may indicate that especially these two misconceptions partly underlie math-gender stereotypes. As a consequence, refutation instructions designed to reduce these misconceptions may be a promising method to weaken math-gender stereotypes. Further research is needed to investigate to what degree reducing the present misconceptions is related to reducing math-gender stereotypes. Hence, this study is the first one of a planned series of studies on the relation between math-gender misconceptions and math-gender stereotypes.
Does It Pay to Issue Green? An Institutional Comparison of Mainland China and Hong Kong’s Stock Markets Toward Green Bonds
Authors: Chen Xingxing , Weber Olaf , Saravade Vasundhara
Published: April 2022

The stock market is an indicator of investor sentiment when it comes to new information or innovative firm-level products. Green bonds are both innovative and unique in terms of their higher information disclosures and understanding the impact of sustainable finance on investor outlook for a company’s stock. Using the comparative case of Mainland China and Hong Kong’s stock market, we examine whether green bond announcements from 2016 to 2019 can create significant investor reactions. By employing the event study methodology, we confirm that both markets react in a positive way toward green bond announcements. This reinforces the reputational and financial benefits of green bonds. We find that issuers that are non-banks, environmentally friendly firms as well as those issuing non-general bonds, create a more positive reaction, whereas ownership aspects do not matter as much for investors. However, even among those issuers listed in both markets, certain institutional dynamics like strategic framing and source credibility tend to reinforce a firm’s institutional legitimacy and are seen as being more prominent for investor reaction. The policy implications of our study show that the stock market reaction among two connected economies, where previously varying institutional contexts have resulted in regional differences, are now equally supportive of sustainable financial markets like the green bond. As seen with the positive stock market sentiment, governments and listed issuers can now better align their policies and internal strategies, allowing the low-carbon transition to be a financially attractive opportunity for all investors.
The Effect of Pre-operative Psychological Interventions on Psychological, Physiological, and Immunological Indices in Oncology Patients: A Scoping Review
Authors: Hanalis-Miller Tsipi , Nudelman Gabriel , Ben-Eliyahu Shamgar , Jacoby Rebecca
Published: April 2022

Introduction

The stressful pre-operative period exerts a profound impact on psychological, physiological and immunological outcomes. Oncological surgeries, in particular, elicit significantly higher stress responses than most other surgeries. Managing these responses through psychological interventions may improve long-term outcomes. The purpose of the current research was to review studies that have explored pre-operative psychological interventions in cancer patients in order to map the types of current interventions and provide an initial assessment of whether these interventions improved psychological, physiological, and/or immunological indices as well as long-term cancer outcomes.

Methods

A systematic literature search for studies that included pre-operative psychological interventions in oncology patients was conducted, using the databases PubMed and Web of Science. Inclusion criteria included studies pertaining to oncological surgery in adults, study designs that included a clearly defined pre-operative psychological intervention and control group.

Results

We found 44 studies, each using one of the following interventions: psychoeducation, cognitive interventions, relaxation techniques, integrated approaches. All the studies reported improved immediate post-operative psychological, physiological, and/or immunological outcomes. Only a few studies addressed long-term cancer outcomes, and only one reported improved survival.

Conclusions

Research on pre-operative interventions with cancer patients is missing systematic methods. Studies provide varying results, which makes it difficult to compare them and reach reliable conclusions. There is considerable heterogeneity in the literature regarding the specific intervention used, the timing of intervention, the characteristics of the patients studied and the outcome measures. In order to improve research in this field, including the measurement of long-term outcomes, we suggest some steps that should be taken in further research.
Crowdfunding Curriculum Design Based on Outcome-Based Education
Authors: Wu Yenchun Jim , Yuan Chih-Hung
Published: April 2022

Entrepreneurship has flourished in recent years; however, since education on how to raise funds has received little attention from scholars, obtaining funds remains a difficult task. The development of crowdfunding has provided new opportunities to entrepreneurs, thus solving the funding, marketing, and distribution problems they previously faced. The main purpose of this study is to organize crowdfunding literature and to develop a crowdfunding curriculum grounded on output-based education. Students are asked to develop a product and a crowdfunding plan within the span of one semester. This study explains the teaching content separately from the crowdfunding plan competition, course elements, and timetable.
Predicting Verbal Learning and Memory Assessments of Older Adults Using Bayesian Hierarchical Models
Authors: Ebrahim Endris Assen , Cengiz Mehmet Ali
Published: April 2022

Verbal learning and memory summaries of older adults have usually been used to describe neuropsychiatric complaints. Bayesian hierarchical models are modern and appropriate approaches for predicting repeated measures data where information exchangeability is considered and a violation of the independence assumption in classical statistics. Such models are complex models for clustered data that account for distributions of hyper-parameters for fixed-term parameters in Bayesian computations. Repeated measures are inherently clustered and typically occur in clinical trials, education, cognitive psychology, and treatment follow-up. The Hopkins Verbal Learning Test (HVLT) is a general verbal knowledge and memory assessment administered repeatedly as part of a neurophysiological experiment to examine an individual’s performance outcomes at different time points. Multiple trial-based scores of verbal learning and memory tests were considered as an outcome measurement. In this article, we attempted to evaluate the predicting effect of individual characteristics in considering within and between-group variations by fitting various Bayesian hierarchical models via the hybrid Hamiltonian Monte Carlo (HMC) under the Bayesian Regression Models using ‘Stan’ (BRMS) package of R. Comparisons of the fitted models were done using leave-one-out information criteria (LOO-CV), Widely applicable information criterion (WAIC), and K-fold cross-validation methods. The full hierarchical model with varying intercepts and slopes had the best predictive performance for verbal learning tests [from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study dataset] using the hybrid Hamiltonian-Markov Chain Monte Carlo approach.
Theory of Mind and Concealing vs. Forthcoming Communication in Adolescence
Authors: Lavoie Jennifer , Talwar Victoria
Published: April 2022

Concealing information requires that adolescents manage the information that they share, which requires cognitive skills, for example, theory of mind (ToM). This study explored motivations for concealment that early adolescents (N = 90, M = 12.81 years, SD = 5.10 months, range 12–14 years, and 58% female) endorsed concealing or disclosing to friends and parents, in relation to their theory of mind. We found that adolescents broadly endorsed disclosure to both parents and friends, even when it might mean they would face consequences, be impolite (by not protecting another’s feelings), or face negative identity-related emotions. We found that ToM ability was associated with a tendency to endorse being forthcoming and sharing information with both friends and parents. These findings provide new insight into how the relation between ToM and concealment may change with age, specifically how in early adolescence it may foster open communication rather than concealment as is the case in early and middle childhood.
Responsivity of the Striatal Dopamine System to Methylphenidate—A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Authors: Aster Hans-Christoph , Romanos Marcel , Walitza Susanne , Gerlach Manfred , Mühlberger Andreas , Rizzo Albert , Andreatta Marta , Hasenauer Natalie , Hartrampf Philipp E. , Nerlich Kai , Reiners Christoph , Lorenz Reinhard , Buck Andreas K. , Deserno Lorenz
Published: April 2022

Background:

Methylphenidate (MPH) is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). MPH binds to the dopamine (DA) transporter (DAT), which has high density in the striatum. Assessments of the striatal dopamine transporter by single positron emission computed tomography (SPECT) in childhood and adolescent patients are rare but can provide insight on how the effects of MPH affect DAT availability. The aim of our within-subject study was to investigate the effect of MPH on DAT availability and how responsivity to MPH in DAT availability is linked to clinical symptoms and cognitive functioning.

Methods

Thirteen adolescent male patients (9–16 years) with a diagnosis of ADHD according to the DSM-IV and long-term stimulant medication (for at least 6 months) with MPH were assessed twice within 7 days using SPECT after application of I-123-β-CIT to examine DAT binding potential (DAT BP). SPECT measures took place in an on- and off-MPH status balanced for order across participants. A virtual reality continuous performance test was performed at each time point. Further clinical symptoms were assessed for baseline off-MPH.

Results

On-MPH status was associated with a highly significant change (−29.9%) of striatal DAT BP as compared to off-MPH (t = −4.12, p = 0.002). A more pronounced change in striatal DAT BP was associated with higher off-MPH attentional and externalizing symptom ratings (Pearson r = 0.68, p = 0.01). Striatal DAT BP off-MPH, but not on-MPH, was associated with higher symptom ratings (Pearson r = 0.56, p = 0.04).

Conclusion

Our findings corroborate previous reports from mainly adult samples that MPH changes striatal DAT BP availability and suggest higher off-MPH DAT BP, likely reflecting low baseline DA levels, as a marker of symptom severity.
Comparisons of Serum Interleukin-8 Levels in Major Depressive Patients With Drug-Free Versus SSRIs Versus Healthy Controls
Authors: Zhu Zhen Hua , Song Xiao Ying , Man Li Juan , Chen Peng , Tang Zhen , Li Rong Hua , Ji Cai Fang , Dai Ning Bin , Liu Fang , Wang Jing , Zhang Jianping , Jia Qiu Fang , Hui Li
Published: April 2022

Objective

The interleukin-8 (IL-8) has been reported to play an important role in depression, which might be modulated by the selective serotonin reuptake inhibitors (SSRIs). Thus, the aim of this study was to investigate serum IL-8 levels, depressive symptom, and their associations in drug-free MDD patients, MDD patients with SSRIs, and healthy controls (HCs).

Methods

Fifty-seven drug-free MDD patients (male/female = 35/22, mean age: 39.24 years), 30 MDD patients with SSRIs (male/female = 11/19, mean age: 39.73 years), and 101 HCs (male/female = 52/49, mean age: 37.38 years) were recruited in this cross-sectional study. Serum IL-8 levels and depressive symptom were assessed using the Flow Cytometer and Hamilton Depression Scale (HAMD). The analysis of variance was used for the comparison between groups. The relationship between serum log10IL-8 levels and HAMD score was analyzed by Pearson correlation.

Results

Serum log10IL-8 levels were lower in all patients than HCs after controlling for covariates (F= 4.86,p= 0.03). There was significant difference in serum Log10IL-8 levels among three groups after controlling for covariates (F= 14.63,p< 0.001). Serum Log10IL-8 levels in drug-free patients were lower compared to HCs (F= 19.38,p< 0.001) or patients with SSRIs (F= 21.89,p< 0.001) after controlling for covariates. However, there was not difference in serum log10IL-8 levels between patients with SSRIs and HCs after controlling for covariates. Moreover, serum Log10IL-8 levels were negatively correlated with HAMD score in all patients (r= −0.37,p= 0.02). Also, serum Log10IL-8 levels were negatively correlated with HAMD score in drug-free patients (r= −0.74,p= 0.01), but not in patients with SSRIs.

Conclusion

Our data supported that the decline in serum IL-8 levels was association with depression. Moreover, the SSRIs might modulate increased serum IL-8 levels of depression.
Glutamatergic Neurons in the Amygdala Are Involved in Paclitaxel-Induced Pain and Anxiety
Authors: Liu Jiaxin , Li Dangchao , Huang Jing , Cao Jing , Cai Guohong , Guo Yuexian , Wang Guiying , Zhao Shuang , Wang Xiuli , Wu Shengxi
Published: April 2022

Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors. However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some patients. In addition, patients received paclitaxel chemotherapy are often accompanied by negative emotions such as anxiety. The amygdala is critically involved in regulating pain signals, as well as anxiety. The purpose of this study is to clarify the role of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons in the amygdala in paclitaxel-induced pain and negative affective symptoms. Intraperitoneal injection of paclitaxel into mice caused mechanical and thermal allodynia, as measured by Von Frey test and Hargreaves test, and anxiety, as measured by open field test and elevated plus maze test. Immunofluorescence staining revealed that c-fos-positive neurons were significantly more in the basolateral amygdala (BLA) and central amygdala (CeA) in paclitaxel-treated mice than untreated mice. Furthermore, part of c-fos-positive neurons in the BLA were immunoreactive of CaMKII. Engineered Designer receptors exclusively activated by designer drugs (DREADD) receptor hM4Di or hM3Dq was selectively expressed on CaMKII neurons by injection of adeno-associated virus (AAV) vectors containing CaMKII and hM4Di or hM3Dq. Administration of DREADD agonist CNO to selectively inhibit the CaMKII neurons in the BLA significantly increased the paw withdrawal thresholds and paw withdrawal latencies. In addition, selectively inhibition of CaMKII neurons in the BLA alleviated anxiety behavior without affecting the motor activity. In summary, our findings suggest that CaMKII neurons in the amygdala are critical for neuropathic pain and anxiety behaviors induced by paclitaxel chemotherapy.
Don't Get Lost in Translation: Integrating Developmental and Implementation Sciences to Accelerate Real-World Impact on Children's Development, Health, and Wellbeing
Authors: Wakschlag Lauren S. , Finlay-Jones Amy L. , MacNeill Leigha A. , Kaat Aaron J. , Brown C. Hendricks , Davis Matthew M. , Franklin Patricia , Berkel Cady , Krogh-Jespersen Sheila , Smith Justin D.
Published: April 2022

Translation of developmental science discoveries is impeded by numerous barriers at different stages of the research-to-practice pipeline. Actualization of the vast potential of the developmental sciences to improve children's health and development in the real world is imperative but has not yet been fully realized. In this commentary, we argue that an integrated developmental-implementation sciences framework will result in a translational mindset essential for accelerating real world impact. We delineate key principles and methods of implementation science of salience to the developmental science audience, lay out a potential synthesis between implementation and developmental sciences, provide an illustration of the Mental Health, Earlier Partnership (MHE-P), and set actionable steps for realization. Blending these approaches along with wide-spread adoption of the translational mindset has transformative potential for population-level impact of developmental science discovery.
Open Debates Conducive for Vaccination Rate Flatlines: A Scoping Review and Convergent Cross Mapping
Authors: Hu Zhiwen , Chen Ya
Published: April 2022

COVID-19 pandemic is fueling digital health transformation—accelerating innovations of digital health services, surveillance, and interventions, whereas hastening social contagion of deliberate infodemic. The USA and many other countries are experiencing a resurgent wave of the COVID-19 pandemic with vaccination rate slowdown, making policymaking fraught with challenges. Political leaders and scientists have publicly warned of a “pandemic of the unvaccinated,” reinforcing their calls for citizens to get jabs. However, some scientists accused elites of stigmatizing the unvaccinated people and undermining the moral pillars of public health. Following the PRISMA-ScR guidelines, we first reviewed the nuances of stakeholders involved in the ongoing debates and revealed the potential consequences of divisive pronouncements to provide perspectives to reframe extensible discussions. Then, we employed the convergent cross mapping (CCM) model to reveal the uncharted knock-on effects of the contentious tsunami in a stakeholders-oriented policymaking framework, coupled with rich metadata from the GDELT project and Google Trends. Our experimental findings suggest that current news coverage may shape the mindsets of the vaccines against the unvaccinated, thereby exacerbating the risk of dualistic antagonism in algorithmically infused societies. Finally, we briefly summarized how open debates are conducive to increasing vaccination rates and bolstering the outcomes of impending policies for pandemic preparedness.
Scaling Up Physical Activity Promotion Projects on the Community Level for Women in Difficult Life Situations and Older People: BIG-5 and GET-10—A Study Protocol
Authors: Till Maike , Abu-Omar Karim , Herbert-Maul Annika , Fleuren Tobias , Reimers Anne Kerstin , Ziemainz Heiko
Published: April 2022

Introduction

Physical inactivity is a major risk factor for a population's health, especially among socially disadvantaged groups. Many health promotion projects focus on increasing physical activity among their respective target groups. However, because they are mostly developed and implemented under laboratory conditions, they fail when being scaled to real-world settings. The community-based participatory research projects BIG and GESTALT have demonstrated their effectiveness regarding the physical activity promotion in real-world settings by employing a participatory method.

Material and Analysis

Within the context of the BIG-5 and GET-10 projects, these previously implemented and tested participatory projects are scaled to 15 additional settings in Bavaria, Germany. By applying an overarching mixed-methods evaluation framework, the aim is to gain insights into a) the recruitment of communities for scale-up; b) the specific results of the projects according to the RE-AIM framework. In the recruitment of communities, standardized information on the first contact, the consultation process, the person in charge, and previously implemented health promotion projects are collected. A systematic web search will complete information on each community and their health promotion activities. Results will be compared with information on those communities most in need, here according to the deprivation index of communities in Bavaria, Germany. The scale-up process and its results will be measured using semi-structured interviews with project coordinators. A standardized questionnaire will be used with the course's participants. Applying the RE-AIM framework, the collected data will be analyzed deductively.

Discussion

We expect the results to be highly relevant for the effective scale-up of any health promotion project. The study will enhance the understanding of how to reach those communities most in need of health promotion projects and will identify the barriers coordinators face in reaching socially disadvantaged groups.

Conclusion

Although participatory projects are often used as individual projects, little is known about the scaling up of participatory health promotion projects. This cross-cutting evaluation of two projects aims at producing data on the barriers and facilitators for the reach of settings most in need, and those success factors for a durable implementation.
Epidemiology of Indigenous Dengue Cases in Zhejiang Province, Southeast China
Authors: Ren Jiangping , Chen Zhiping , Ling Feng , Huang Yangmei , Gong Zhenyu , Liu Ying , Mao Zhiyuan , Lin Chunping , Yan Hao , Shi Xuguang , Zhang Rong , Guo Song , Chen Enfu , Wang Zhen , Sun Jimin
Published: April 2022

Objective

Autochthonous transmission of the dengue virus (DENV) occurred each year from 2014 to 2018 in Zhejiang province, and became an emerging public health problem. We characterized the autochthonous transmission of the DENV and traced the source of infection for further control and prevention of dengue.

Methods

Descriptive and spatiotemporal cluster analyses were conducted to characterize the epidemiology of autochthonous transmission of the DENV. Molecular epidemiology was used to identify the infection source.

Results

In total, 1,654 indigenous cases and 12 outbreaks, with no deaths, were reported during 2004–2018. Before 2017, all outbreaks occurred in suburban areas. During 2017–2018, five out of eight outbreaks occurred in urban areas. The median duration of outbreaks (28 days) in 2017–2018 was shortened significantly (P = 0.028) in comparison with that in 2004–2016 (71 days). The median onset-visiting time, visiting-confirmation time, and onset-confirmation time was 1, 3, and 4 days, respectively. The DENV serotypes responsible for autochthonous transmission in Zhejiang Province were DENV 1, DENV 2, and DENV 3, with DENV 1 being the most frequently reported. Southeast Asia was the predominant source of indigenous infection.

Conclusions

Zhejiang Province witnessed an increase in the frequency, incidence, and geographic expansion of indigenous Dengue cases in recent years. The more developed coastal and central region of Zhejiang Province was impacted the most.
Inclusive Insurance, Income Distribution, and Inclusive Growth
Authors: Zheng Lili , Su Ya
Published: April 2022

Financial inclusion, whereby all adults have effective access to financial products, including insurance, has increasingly become a global priority, particularly in low and middle income economies. This study matches the measured development level of inclusive insurance in Chinese provinces with China Family Panel Studies (CFPS) data and evaluates the impact of inclusive insurance on income distribution and inclusive growth. The findings support that inclusive insurance has a positive impact on income distribution and inclusive growth. The effect is more pronounced in eastern areas, rural areas and low-income households. The policy shocks and instrumental variables introduced prove the robustness of the results. PSM-DID test indicate that the inclusive insurance policy has a significant positive effect on income distribution. Alternative measure of inclusive insurance and GMM test with instrumental variables indicate that the results are robust. Additionally, we also find that there is a threshold effect on the impact of the inclusive insurance on income. When the universal insurance index exceeds the threshold value, the promoting effect on income is enhanced.
Toward a Reliable Correction of NOAA AVHRR Orbital Drift
Authors: Julien Yves , Sobrino José A.
Published: April 2022

The NOAA (National Oceanic and Atmospheric Administration) AVHRR (Advanced Very High-Resolution Radiometer) orbital drift prevents the use of its derived land surface temperature (LST) data for global studies of temperature trends, especially for the 80s and 90s over land. In a previous study, we showed how orbital drift correction methods could be validated by simulating a reference and drifted time series from alternative MSG (Meteosat Second Generation) SEVIRI (Spinning Enhanced Visible and InfraRed Imager) data, thanks to their high (15 min) temporal resolution. In this study, we show how these alternative data allow identifying orbital drift effects on different land covers, and how these effects could be mitigated with novel approaches. We also identify two key statistical parameters to assess orbital drift correction performance: the bias between corrected and drifted time series and the trend of their difference. We present two methods and compare their results with an alternative orbital drift correction, validated against in situ data by their authors. Considering an ideal case where the whole influence of the orbital drift is known, our novel approach allows for an almost complete removal of the orbital drift effect (zero bias and 0.05 K/yr difference trend). However, in real cases, when we have only access to the drifted time series, our approach’s performance decreases slightly, mainly through a larger spread of the retrieved statistics. As for the alternative correction method, its performance is poorer, even if it actually succeeds in removing part of the observed orbital drift. These results, as well as the new insights we provide on the orbital drift effect on LST, pave the way toward a reliable correction of NOAA AVHRR orbital drift. We therefore recommend the use of simulated LST time series such as the ones used in this study for the validation of orbital drift correction methods.
Axons in Trouble Yelp for Help From Schwann Cells
Authors: Islam Rakibul , Hurtado Danielle , Elias Zeev , Babetto Elisabetta , Beirowski Bogdan
Published: April 2022

The axons of our nerves are like long wires that carry important communication signals around the body. Axons are not alone in nerves; they are surrounded by special cells called Schwann cells. This companionship allows our bodies to do things such as go to school, catch a ball, and eat. In some people with illnesses called neuromuscular diseases, axons fall seriously sick and may wither away. We discovered that when axons become sick, Schwann cells quickly detect the issue. The Schwann cells act as an emergency-response team that delivers an extra supply of special sugars to axons in need. This sugar-boost makes harmed axons stronger and allows them to recover. We hope that this discovery will lead to novel therapies that will help keep axons alive in sick people.
The Power of Your Adrenal Glands to Help You Cope With Stress
Authors: Ruiz-Babot Gerard , Becerra Miriam Veiras
Published: April 2022

Whenever you face a difficult exam at school, you may feel nervous and stressed. In these situations, your adrenal glands kick in. These glands are located on the tops of the kidneys. The main job of the adrenal glands is to produce hormones, which are molecules responsible for many functions in the body. One of the hormones produced by the adrenal glands is called cortisol. Cortisol helps us manage stressful situations. However, some people’s bodies fail to produce cortisol. These people suffer from what is called Addison’s disease, and they must be treated with cortisol for life. In this article, we will learn what the adrenal glands are, what they do to help the body to be healthy, and how people with Addison’s disease manage that condition.
Staying in or Dropping Out of Elite Women's Football—Factors of Importance
Authors: Bjerksæter Ingrid Amalie Hoftun , Lagestad Pål Arild
Published: April 2022

The average age of elite women footballers in Norway is 22.7 years, significantly lower than that of elite male footballers in Norway (26.5). This study examines the factors leading to elite female footballers ending their careers at a relatively young age, and those factors influencing other female elite players to continue. Semi-structured interviews were conducted with five female elite players who had ended their career at the age of 19–24, and four who were still active (age 26–31). Based on the age of the informants who had ended their career and the informants who were still active, this study defines “young age” as <25years of age. The female elite players experiences were analyzed and discussed in relation to earlier research. The results of the study show that the same factors affecting the early end of a career, also had an impact on continuing the career in the Norwegian top league, beyond the average age. A low level of internal and external motivation, poor financial circumstances, high stress load, long injury breaks, lack of playing time and other priorities, are all factors leading elite players to end their football careers at a young age. These factors are increasingly being addressed in relation to still active elite players, and this has an impact on the length of their playing career. Like earlier research, this study indicates that the emergence of Norwegian women's football in recent years has helped to improve conditions for being female elite players in the professional leagues in Norway.
Prevalence and Self-Perceived Experiences With the Use of Hormonal Contraceptives Among Competitive Female Cross-Country Skiers and Biathletes in Norway: The FENDURA Project
Authors: Engseth Tina P. , Andersson Erik P. , Solli Guro S. , Morseth Bente , Thomassen Tor Oskar , Noordhof Dionne A. , Sandbakk Øyvind , Welde Boye
Published: April 2022

Purpose

To investigate the prevalence of hormonal contraceptive (HC) use by female cross-country (XC) skiers and biathletes competing at a national and/or international level, their reasons for HC use, and to compare negative symptoms related to the HC-/menstrual cycle in HC users and non-HC users. Additionally, to characterize the self-perceived influence of HC use on training and performance.

Methods

A total of 113 Norwegian competitive XC skiers and biathletes completed an online questionnaire including both closed and open-ended questions. The questions were designed to assess the type of HC, reasons for use, self-reported negative symptoms related to HC-/menstrual cycle, as well as athletes' experiences regarding how HC use affects training and performance.

Results

In total, 68% of all the athletes used HC, with 64 and 36% of them using a progestin-only and combined type HC, respectively. Non-contraceptive reasons for HC use were reported by 51% of the progestin-only HC users vs. 75% of the combined HC users (P = 0.039), with reduction of negative menstrual-related symptoms as the most common reason. Of the athletes reporting regular withdrawal bleedings in connection to HC use, 80% of the progestin-only and 86% of combined HC users experienced negative menstrual-related symptoms, which was comparable to the non-HC group (86%). The majority (81%) of HC users experienced solely positive, or no effect, of HC use on training and performance, with no differences between progestin-only and combined HC users (P = 0.942).

Conclusions

In total, 68% of the XC skiers and biathletes used HC, with the highest proportion (64%) using a progestin-only HC. Many athletes used HC to manipulate their menstrual cycle due to perceived negative menstrual-related symptoms that interfered with their training sessions and/or competitions.