bluuebunny/crossref_metadata_2025 huggingface dataset:
GAMBARAN HASIL PEMERIKSAAN URINALISIS PADA PASIEN INFEKSI SALURAN KEMIH YANG TERPASANG KATETER DI RUANG RAWAT INAP PENYAKIT DALAM RSUD Dr. H. ABDUL MOELOEK PROVINSI LAMPUNG
Authors: Kumala Indra , Triswanti Nia , Hidayat Hidayat , Terta Riesca Lavenia
Published: March 2023

Infeksi saluran kemih adalah suatu keadaan yang menunjukan adanya mikroorganisme dalam saluran kemih yang dapat ditandai adanya kolonisasi bakteri di dalam saluran kemih. Kasus infeksi saluran kemih adalah kejadian infeksi nosokomial masih masuk kategori tersering sekitar 40% sedangkan infeksi saluran kemih yang dihubungkan dengan penggunaan kateter terjadi sekitar 80%. Tujuan penelitian untuk mengetahui gambaran hasil pemeriksaan urinalisis pada pasien infeksi saluran kemih yang terpasang kateter di ruang rawat inap penyakit dalam RSUD Dr. H. Abdul Moeloek Provinsi Lampung. Penelitian ini menggunakan sampel pasien yang terdiagnosis infeksi saluran kemih yang melakukan pemeriksaan urinalisis yang terpasang kateter di ruang rawat inap penyakit dalam RSUD Dr. H. Abdul Moeloek Provinsi Lampung Tahun 2019-2021. Berdasarkan hasil penelitian didapatkan usia 56-65 tahun sebanyak 20 (40,0%). Jenis kelamin perempuan 44  (88,0%). Sedimen urin jumlah leukosit positif 2 (++) 5-9 sel/ LPB berjumlah 17 (34,0%). Sedimen urin eritrosit ditemukan hasil terbanyak eritrosit positif 1 (+) 1-4 sel / LPB berjumlah 19 (38,0%). Hasil pemeriksaan urinalisis sel epitel ditemukan hasil terbanyak epitel positif 1 (+) 1-4 sel / LPB berjumlah 35 (70,0%). Hasil pemeriksaan urinalisis jumlah nitrit yang terbanyak negatif berjumlah 43 (86,0%). Hasil pemeriksaan urinalisis jumlah leukosit esterase yang terbanyak leukosit esterase positif 3 (+++) berjumlah 23 (46,0%).
Scrofuloderma : Etiologi, Diagnosis, Tatalaksana
Authors: Alhafiz Virgiansya , Ismunandar Helmi , Wintoko Risal , Hadibrata Exsa , Djausal Anisa Nuraisa
Published: March 2023

Tuberkulosis kulit adalah bentuk tuberkulosis ekstrapulmoner yang jarang, terdiri dari 1-2% kasus. Disebabkan oleh Mycobacterium tuberculosis atau galur terkait, penyakit ini menghadirkan berbagai manifestasi klinis, meniru penyakit kulit kronis lainnya dan menyebabkan diagnosis tertunda. Sebuah kasus skrofuloderma dilaporkan, yang diagnosis dan pengobatannya hanya dibuat enam tahun setelah timbulnya penyakit
JAMINAN MUTU PESAWAT CT SCAN SINGLE SLICE DI UNIT RADIOLOGI RSU SEMARA RATIH
Authors: Prasetya I Made Lana , Arthana I Putu Juli
Published: March 2023

Latar Belakang: Pesawat CT Scan single slice Merk SIEMENS/Dura 302 MV di unit Radiologi Rumah Sakit Umum Semara Ratih Kabupaten Tabanan Bali terpasang pada bulan Nopember 2020 merupakan alat second hand dengan tahun produksi 2012. Pelaksanaan kendali dilakukan pada saat penerimaan (acceptance test) meliputi pengujian terhadap indeks dosis  CT (CTDI) untuk  kepala, indeks dosis  CT (CTDI untuk badan, CT-Number udara, kesesuaian table slice dengan setting semua slice, indikator posisi meja (sumbu z), laser penanda dan pada bulan april 2021 yang dilakukan oleh Badan Pengawas Fasilitas Kesehatan (BPFK) Surabaya meliputi uji teknis generator dan tabung sinar-X (uji akurasi tegangan tabung, uji kualitas berkas sinar-X), uji kualitas citra (uji akurasi CT number air, keseragaman CT number), dan pelaksanaan kendali mutu rutin peralatan radiologi jarang dilaksanakan secara berkesinambungan untuk menjaga kinerja pesawat CT Scan. Metode penelitian: kualitatif deskriptif dengan pendekatan survey. Hasil dan Pembahasan: Pengujian yang telah dilakukan diperoleh nilai rata rata CT number untuk water phantom pada lima posisi yang berbeda adalah -1,68; -0,76; -2,21; -1,77; -1,53 HU dan semua berada pada rentang nilai toleransinya yaitu -4 sampai 4 HU. Pengujian Dry laser printer dengan dengan hasil sebagaian besar masih sesuai parameter uji yang berlaku, hanya pada pattern 0% terdapat nilai uji yang melebihi standar artinya quality control untuk Dry laser printer di Unit Radiologi RSU Semara Ratih tidak sasuai dengan standar sehingga di perlukan kalibrasi. Pada Pengujian form check list yang telah dilakukan di Unit Radiologi RSU Semara Ratih untuk mengetahui ada tidak nya  tombol alat yang tidak berfungsi dengan hasil semua fungsi dan tombol masih berfungi dengan baik. Kesimpulan: Hasil uji kesesuaian pada Pesawat CT Scan single slice Merk SIEMENS/Dura 302 MV di unit Radiologi Rumah Sakit Umum Semara Ratih Kabupaten Tabanan Bali dalam batas normal kecuali pada dry laser printer.
TANTANGAN MENYUSUI PADA IBU PEKERJA DI INDONESIA
Authors: Akbar Tasya Khariena , Mayasari Diana , Berawi Khairun Nisa , Anggraini Dian Isti
Published: March 2023

Pertumbuhan yang pesat terjadi pada masa bayi, sehingga diperlukan nutrisi dengan gizi yang optimal untuk memenuhi kebutuhan bayi yaitu ASI. Menyusui sangat penting untuk kelangsungan hidup anak dan mencegah anak dari ketidakcukupan gizi pada masa bayi. Pada tahun 2022 diperkirakan sekitar 44% bayi baru lahir diseluruh dunia diberikan ASI eksklusif pada 6 bulan pertama kehidupan. Di Indonesia dari 2,3 juta bayi hanya 52,5% yang diberikan ASI eksklusif, angka tersebut menurun dari tahun 2019 yaitu sebesar 64,5%. Prevalensi pemberian ASI eksklusif pada ibu pekerja bahkan jauh lebih rendah lagi. Menurut RISKESDAS tahun 2012 pemberian ASI eksklusif pada ibu pekerja hanya sebesar 32%.Salah satu penyebab utama penurunan pemberian ASI pada bayi adalah institusi yang mempekerjakan perempuan tidak memberikan kesempatan untuk ibu menyusui, sehingga ibu pekerja memiliki tantangan tersendiri dalam menyusui. Tantangan menyusui yang dapat dihadapi oleh ibu pekerja di Indonesia antara lain kurangnya kepercayaan diri ibu, banyaknya waktu yang tersita karena pekerjaan, tempat bekerja yang tidak difasilitasi dengan ruang menyusui, masa cuti yang hanya sebentar, alat pendingin ASI atau alat pompa ASI tidak dapat digunakan secara optimal, ketidakyakinan dari  dalam diri ibu dalam memberikan ASI, hambatan yang muncul dari keluarga, pimpinan, dan rekan kerja, serta sikap dan pengetahuan ibu yang negatif terhadap ASI eksklusif.  Tantangan tersebut umumnya dihadapi oleh ibu pekerja dan membutuhkan solusi yang tepat agar tantangan yang muncul tidak menjadi hambatan dalam mewujudkan keberhasilan menyusui bagi ibu pekerja.
Hubungan Pengaruh Polimorfisme Genetik Terhadap Risiko Kejadian Diabetes Melitus
Authors: Yunita Elvira , Putri Cindy Ernica , Indrian Audia , Umar Liya Agustin , Dita Diah Ayu Aguspa
Published: March 2023

Diabetes adalah suatu keadaan adanya gangguan metabolik yang terjadi jangka panjang/kronis ditandai dengan tingginya kadar glukosa darah yang disebabkan oleh defisiensi insulin absolut maupun relatif, disfungsi sel β, resistensi insulin atau dapat terjadi keduanya. Diabetes melitus secara diklasifikasikan menjadi beberapa jenis, dan yang paling umum diketahui adalah diabetes melitus tipe 1 dan tipe 2. Faktor-faktor yang berhubungan dengan angka kejadian DM diantaranya adalah overweight, obesitas sentral/abdominal, derajat stress, kurangnya aktifitas fisik, hipertensi, dislipidemia, kondisi prediabetes, merokok, ras, etnik, umur, jenis kelamin, riwayat keluarga dengan diabetes melitus. Faktor genetik diketahui mempunyai peranan yang cukup penting dalam kejadian, perjalanan dana perkembangan penyakit DM. Faktor genetik yang paling umum berperan adalah Single Nucleotide Polimorphism (SNP). Gen yang diketahui mempunyai hubungan yang erat dengan DMT1 antara lain  gen HLA, CTLA-4, PTPN22, dan IL2RA/CD25. Pada DMT2 terdapat beberapa gen yang berperan yaitu gen ABCC8, KCNJ11, PPAR-γ dan CALPN10.
Studi Literatur : GEJALA VASOMOTOR MENOPAUSE
Authors: Shariff Fonda Octarianingsih , Sirojuddin Mohammad , Prameswari Kevin Andara Setya
Published: March 2023

Abstrak: Gejala Vasomotor Monopause. Menopause adalah berhentinya haid secara permanen setelah didahului oleh amenorea selama minimal satu tahun beserta gejala pada masa transisinya. Usia menopause pada wanita dapat terjadi pada usia 45-50 tahun namun pada beberapa keadaan dapat terjadi lebih awal atau terlambat. Menopause dini adalah menopause yang terjadi pada usia kurang dari 40 tahun. Masa transisi dan proses menopause masih menjadi mengkhawatirkan bagi kaum wanita baik dari perubahan fisik, gejala yang dirasakan dalam aktivitas sehari-hari termasuk aktivitas seksual, dan beragam penyakit yang menyertai setelah menopause. Gejala vasomotor, salah satunya, merupakan gejala menopause yang kadang diabaikan, tidak terdiagnosis dan tidak ditatalaksanai dengan sesuai sehingga dapat berdampak negatif pada kualitas hidup. Berbagai penelitian telah dilakukan baik secara hormonal dan nonhormonal untuk mengatasi gejala vasomotor seperti hot flushes dan keringat malam hari.
PENGARUH PEMBERIAN EKSTRAK BUNGA PEPAYA (CARICA PAPAYA L) TERHADAP KADAR KOLESTEROL DARAH TOTAL DAN MASSA LEMAK ABDOMINAL PADA TIKUS YANG DIBERI DIET TINGGI LEMAK
Authors: Fitriani Dita , Rusmini Hetti , Gafar Miftahul Jannah
Published: March 2023

Abstrak : Pengaruh Pemberian Ekstrak Bunga Pepaya (Carica Papaya L) Terhadap Kadar Kolesterol Darah Total Dan Massa Lemak Abdominal Pada Tikus Yang Diberi Diet Tinggi LemakHiperlipidemia adalah kondisi kadar lipid di dalam darah melebihi batas normal ditandai dengan peningkatan kadar kolesterol darah total, yang kemudian berdampak pada peningkatan akumulasi lemak tubuh terutama lemak sentral di  abdomen. Bunga papaya mengandung senyawa yang mampu mempertahankan kadar kolesterol dalam batas normal karena mengandung senyawa flavonoid dan tanin yang berperan sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak bunga pepaya (Carica papaya L) terhadap kadar kolesterol darah total dan massa lemak abdominal. Penelitian eksperimental murni ini menggunakan 25 ekor tikus Sprague dawley jantan berusia 12-16 minggu dengan berat 200-250 gram. Tikus dibagi menjadi 5 kelompok yaitu; kelompok tikus yang diberi pakan standar (K), kelompok tikus yang diberi diet tinggi lemak (KN), kelompok tikus yang diberi diet tinggi lemak dan ekstrak bunga papaya 31 mg/kgBB (P1), kelompok tikus yang diberi diet tinggi lemak dan ekstrak bunga papaya 62 mg/kgBB (P2), kelompok tikus yang diberi diet tinggi lemak dan ekstrak bunga papaya 125 mg/kgBB (P3). Hasil penelitian menunjukkan pemberian ekstrak bunga pepaya menyebabkan terjadinya penurunan kadar kolesterol darah total pada semua kelompok perlakuan (p<0,05) dan penurunan massa lemak abdominal pada kelompok P2 dan P3 (p<0.05).
Hybrid-based Recommender System for Online Shopping: A Review
Authors: Lim Ying Fei , Haw Su Cheng , Ng Kok Why , Anaam Elham Abdulwahab
Published: March 2023

In the era of the digital revolution, online shopping has developed into a remarkably simple and economical option for consumers to make purchases securely and conveniently from their homes. In order for the online merchant to optimize their profit, the online shopping platform must always display a list of potential products that customers may purchase. The recommender system kicks in at this point to assist in finding products that customers would like and recommend a list of product recommendations that match the customer's preferences. This paper reviews the recommender system technology in detail by reviewing the classification technique. Other than that, the related works will be reviewed to understand how each technique works, the strengths and limitations, the datasets and evaluation metrics employed.
Severity and burden of sickle cell disease in France: a nationwide realworld study
Authors: Brousse Valentine , Bernaudin Francoise , Melaine Asma , Goguillot Melanie , Gallagher Meghan , Benard Steve , Habibi Anoosha
Published: March 2023

The burden of sickle cell disease (SCD) in France has been difficult to apprehend due to the paucity of reliable nationwide epidemiological data. We aimed to describe the epidemiology of SCD and evaluate its burden and costs. Patients with SCD and most severely affected patients were identified between 2012 and 2018 from the French National Health Data System database (SNDS, Systeme national des donnees de sante). Outcomes of interest included rates of acute and chronic complications, healthcare resource utilisation and associated costs, and were compared in subpopulations of patients before and after Hematopoietic Stem Cell Transplantation (HSCT), initiating hydroxyurea (HU) or a chronic transfusion program (CTP). Between 2012 and 2018, 22,619 patients with SCD were identified, among which 4,270 patients were defined as most severely affected. Rates of vaso-occlusion (VOC) episodes and acute chest syndrome (ACS) were 86.29 [95CI%: 85.75; 86.83] and 12.90 [95%CI: 12.69; 13.11] per 100 person-years in study population and 166.9 [95%CI: 165.4; 168.4] and 22.71 [95%CI: 22.16; 23.27] per 100 person-years in most severely affected patients. Median (Q1-Q3) annualised total costs were €5,073.63 (1,633.74-14,000.94) and €13,295.67 (5,754.67-26,385.23) in study population and most severely affected patients. Median annualised costs were 10 times lower after treatment intensification for HSCT (€29,011.75 vs €2,465.98, p
The Innovation of Pesantren Development in Aceh Province through the Effectiveness of Organizational Culture
Authors: Siregar Fauzan Ahmad , Prasetyo Muhammad Anggung Manumanoso
Published: March 2023

This study aimed to reveal the Dayah Perbatasan innovation based on the concept of organization development. Dayah Perbatasan is a government-affiliated Islamic boarding school educational institution. Operatively, Dayah Perbatasan is under Aceh province's education department. The research method used in descriptive qualitative approach. The subject of this study were pesantren leaders, school principal, vice of curriculum and pesantren senior teacher. The data collection technique used observation, interviews, focus group interviews and analysis of documentation materials. The data were analyzed by using the constant comparative analysis method. Based on the result, there were three innovations in the Dayah Perbatasan, first work engagement; second, leadership trust and the last organization management; These three innovations could lead the Dayah Perbatasan to be an innovative Islamic Boarding School in Aceh Province. This study has the originality of the concept value of developing pesantren government-style. In addition, the study adopted the development theory of change management organizations integrated with various factors related to boarding school changes.
Mapping of Disability Management Publications Using Bibliometric Analysis
Authors: Prasetya Budi Agung , Tunas Billy , Parimita Widya , Setiawan Adi
Published: March 2023

This research aims to identify scientific mapping and research developments related to Disability Management. Research related to disability management is needed to guide the implementation of disability management. The research method used a qualitative method using a historical approach. The research data were articles published by reputable journal publishers that use the Publish or Perish (PoP) application. Data analysis used bibliometric analysis assisted by VOSviewer. The bibliometric output visualized the keyword network and maps obtained from the titles and abstracts contained in the collected articles. The study results showed that the mapping and development of studies related to stability management are as follows: First, the publication trend of articles related to disability management which began in 1987, experienced fluctuating conditions. The data showed that research related to disability management was starting to receive attention from academics. Second, the results of the co-authorship analysis showed that there were 149 collaborating on research. Eleven authors carried out the most significant collaborations. The most articles produced by the author are seven articles. This condition showed the authors' high commitment to continue developing knowledge related to disability management. Third, a Network Visualization analysis with VOSviewer software produced 133 keywords related to stability management. These keywords were divided into 11 clusters. Keywords that were often researched were related to "intellectual disability", "perspective", "equity", "organization", "fairness", "risk, individual", "competence", "management disability practice" and "disability prevention".
Morphological Error Analysis in Students' Explanatory Text : An Analysis Based on Gender
Authors: Tahir Moh , Rahayu Hardianty , Ali Ali , Idris Idris , Suputra Gusti Ketut Alit
Published: March 2023

This study aims to analyze the form of morphological errors in student explanatory text based on gender. This research was a multi-case study with a qualitative approach. This study's type of data was written from the explanatory essays of 78 students from three junior high schools in Palu. Data was collected using the listening method obtained from collecting student assignments using reading and note-taking techniques. Data analysis in this study used four methods, namely 1) data collection, 2) data reduction, 3) data presentation, and 4) conclusion drawing. Presentation of the results of data analysis using informal methods. Based on the study's results, morphological errors were found in the explanatory essays of Grade VIII students. The errors referred to 1) Affixation Errors (13 errors), 2) Reduplication Errors (18 errors), and 3) Compound Errors (6 errors). Both genders made similar mistakes regarding abbreviating morphs and compounding but differ regarding affixation and reduplication. Female students made more affixation errors, specifically omission errors. Meanwhile, male students made more reduplication errors. Morphological errors in students' explanatory essays can serve as a barometer for improving comprehension of good Indonesian. Morphological errors in students' explanatory essays can be a benchmark for increasing understanding of good Indonesian rules.
Employing Fuzzy-weighted SERVQUAL, Refined-KANO, IPA, and QFD to Assess Service Quality in Vocational Higher Education
Authors: Surtiningtyas Sri Rahayu , Saputra Surya Tri
Published: March 2023

This research aims to evaluate the quality of vocational higher education services and determine which characteristics most influence service quality. The research used multiple service quality methods, including Fuzzy Weighted SERVQUAL, Refined Kano, Importance-Performance Analysis, and Quality Functional Deployment. This study was conducted in 7 aviation polytechnics: Indonesian Aviation Polytechnic Curug, Medan Aviation Polytechnic, Palembang Aviation Polytechnic, Surabaya Aviation Polytechnic, and Makassar Aviation Polytechnic, and Aviation Polytechnic Jayapura under the Human Resources Development Centre for Air Transportation - Ministry of Transportation. Random sampling was used to determine the number of samples. The population was 3063 cadets, with 507 samples drawn from seven Aviation Polytechnics in Indonesia. The research instrument was a questionnaire with Servqual dimensions and attributes that meet two criteria: service quality Servqual includes five dimensions and attributes of service quality in vocational higher education comprising 23 attributes. The data analysis techniques used were both quantitative and qualitative. The results of this study found that; (1) Of the 23 service quality items at vocational colleges, 14 items are the voice of customers for the Cadets of the seven aviation polytechnics under the PPSDMPU with modern or up-to-date practice lab equipment as the most item that needed to be improved. (2) Formulate 22 alternative technical problem-solving sequentially according to priority with the fulfillment of items carried out by considering the capability of the resources owned by each aviation polytechnic with the application of rights and obligations to all learners as the most quality characteristics that should be implemented.
E-Module Development of Sustainable Coffee Processing to Improve Vocational Students’ Green Skills
Authors: Handayani Mustika Nuramalia , Ramadhan Muhammad Oka , Maharani Shinta , Cakrawati Dewi , Mukhidin Mukhidin
Published: March 2023

This study aimed to analyze the eligibility of e-module and the effectiveness of their use in improving the green skills of vocational students. This research used development research using the ADDIE model (analysis, design, development, implementation, and evaluation). The components of green skills studied in this study include knowledge of the impact of coffee processing on the environment, waste management, and sustainable coffee processing innovations. Data collection was carried out through validation sheets distributed to validators to determine the feasibility of the e-module. In addition, test questions were used in this study to determine the effectiveness of the e-module in improving students' green skills. Furthermore, the data were analyzed using the N-gain test. The results showed that the E-module was eligible according to material experts, learning media experts, and linguists. In addition, the e-module is quite effective in improving vocational students' green skills. The results of this study indicate that the integration of the concept of sustainable coffee processing into learning media is the right decision for improving the green skills of vocational students
Atypical Ischemic Cranial Nerve Palsy in a Diabetic Patient
Authors: Choi Ju Won , Mun Junho , Kong Jeong Han , Choi Youn Joo
Published: March 2023

Purpose: We report an atypical case of ischemic oculomotor palsy occurring sequentially in both eyes and then improving, followed by a new abducens palsy in a diabetic patient with poor blood sugar control.Case summary: A 51-year-old woman presented with diplopia, dizziness, and pain in the right eye and was diagnosed with oculomotor palsy in the right eye. Magnetic resonance imaging of her brain was normal but glycated hemoglobin concentration was 13.4%. After 2 months, the third nerve palsy in the right eye had recovered completely but a new third nerve palsy occurred in the left eye. 1 month later, the symptoms had improved, and the patient did not return to our clinic until 18 months later, when she returned with new diplopia. This time, she was diagnosed with a sixth nerve palsy in the left eye and was observed while controlling her blood sugar. She recovered after 4 months.Conclusions: Generally, cranial nerve palsies occur unilaterally in situations that can cause ischemia, such as diabetes, high blood pressure, and hyperlipidemia. Rarely, they occur bilaterally, or two or more cranial nerve palsies occur simultaneously. However, it is very rare that cranial nerve palsy occurs sequentially in both eyes under the same systemic blood sugar control. Diabetic patients with poor blood sugar control require long-term monitoring, considering the possibility of symptoms developing in both eyes with a time lag or other forms of ischemic cranial nerve palsy.
Challenges for palliative care in times of COVID-19: a scoping review protocol
Authors: Lourenço Marisa , Gomes Tânia , Araujo Fátima , Ventura Filipa , Silva Rosa
Published: March 2023

Introduction: The COVID-19 Pandemic had a major impact on health personnel, families and the person receiving palliative and end-of-life care. Global measures to reduce contamination have forced a change in the practice. The fear of getting infected, restricted visits and the use of personal protective equipment challenged communication between the multidisciplinary team and the person and family in palliative and end-of-life care. The suffering of an end-of-life experience was compounded by long periods of loneliness. Synthesizing evidence from these experiences can inform decision-making and health policy for future global pandemics. Objectives: To map the experience of health personnel, the person and the family in palliative and end-of-life care, during the COVID-19 pandemic. Methods: This scope review will follow the JBI methodology for scoping reviews. Two independent reviewers will evaluate the articles and extract and synthesize the data. It will include studies published in Spanish, English and Portuguese, since March 2020. The following electronic databases will be searched: CINAHL Complete, MEDLINE, Scopus, SciELO, Psychology and Behavioral Sciences, MEDIClatina Cochrane Central Register of Controlled Trials and Access Scientific Repository, opened in Portugal. Results: This scoping review is expected to include studies that address the experience of health personnel, the person and the family in the context of palliative and end-of-life care during the COVID-19 pandemic. Conclusion: This scoping review will analyze and synthesize the available scientific evidence on the experiences of health personnel with people and families in palliative care during COVID-19. It can also be the basis for a systematic review and/or help identify gaps where it may be important to invest in the future. The protocol for this revision is registered with OSF under number OSFHOME-z6agy-v1.
Apendicite aguda na gravidez: uma revisão integrativa
Authors: Zanuto Thiago Silva , Silva Laura Vilela Buiatte , Zanuto Bruno Silva , Gondin Milena Bavaresco , Daguer Julia Resende , Lobo Nayara Silva , Carpanezi Ana Luísa Tano Sanches
Published: March 2023

Introdução: A Apendicite aguda na gravidez é a causa mais comum de doença abdominal não-obstétrica que determina a necessidade de cirurgia de urgência. Objetivo: Analisar os métodos utilizados para diagnosticar e tratar a apendicite aguda em pacientes gravidas, visando também diferenciar esses métodos quando realizados a pacientes não gravidas. O  presente  artigo  trata-se  de  uma  revisão  integrativa  de  literatura.  Foram  utilizado  os  bancos  de  dados  de  artigos científicos  para  realizar  as buscas:Us National  Library  Of  Medicine (PUBMED)  e Scientific  Electronic Library  Online (SCIELO). Foi utilizado os termos para ir de encontro à temática: “ Apendicite” AND “Gravidez” AND “Laparoscopia”. O recorte temporal engloba artigos publicados entre 1995 e 2022. A apendicite aguda na mulher gravida tem seu diagnostico dificultado devido as alterações anatomias e fisiológicas consequentes da gravidez, como por exemplo o deslocamento do apêndice devido ao crescimento do  útero. Em caso de apendicite aguda na mulher a cirurgia por vídeo laparoscopia é o melhor método a ser empregado, uma vez que proporciona vantagens no pós-operatório que a cirurgia a céu aberto não proporciona. A apendicite aguda em gravidas mesmo apresentando baixa mortalidade nos dias atuais, precisa ter seu diagnóstico feito de forma rápida uma vez que a perfuração do apêndice pode elevar a mortalidade e colocar mãe e feto em risco.
Laboratory and Imaging follow-up of the patient with Boné Paget´s
Authors: Andrade Glória Maria Barroso Rodrigues , Lima Júnior Francisco Jucier de , Tavares Neto Manoel Edenor , Brito Carla Maria Soares , Souza Luan Kelves Miranda de
Published: March 2023

Paget's Disease of Bone (POD) has a viral and/or hereditary etiology, its strong familial component is noticeable, since 40% of patients have a family history of the disease, strengthening the idea that there is an autosomal dominant inheritance pattern. The main follow-up method used for patients with POP is the measurement of serum alkaline phosphatase, which is also used to assess the initial response to treatment. The purpose of this bibliographical study is to present, synthesize and describe the most relevant aspects that guide the medical follow-up of patients diagnosed with Paget's Disease of Bone, in order to cite and analyze the importance of medical action in the care of these patients, in an attempt to generate knowledge and updates that help in dealing with these patients, above all, to avoid the evolution of the disease and the appearance of possible complications. UpToDate, Scielo, Virtual Health Library (VHL), PubMed and ebscohost were used as databases, using the following descriptors: Paget's disease, laboratory monitoring, imaging tests, genetics and complications. The pagetic patient can evolve with osteosarcoma, irreversible hearing loss and paraplegia, making its multidisciplinary follow-up essential, through serum and bone alkaline phosphatase dosages, as well as the use of imaging tests, such as scintigraphy and radiography, for research of structural complications or neoplastic transformations, aiming at symptomatic relief along with delaying the progression of the disease, avoiding the total disability of the patient.
Situação Epidemiológica da sífilis congênita em um estado da Amazônia Ocidental
Authors: Sousa Carlos Eduardo da Silva , Paes Thais de Lima , Nogueira Gustavo Eugênio Junqueira , Fernandes João Pedro Pires , Mafaldo Stephany de Lima , Bezerra Ana Clívia Ramos Fecury , Castro Emanuelli Novais da Silva , Araújo Brenda de Souza , Sampaio Ingrid Natascha de Souza , Costa Ruth Silva Lima da
Published: March 2023

Objetivou-se analisar a situação epidemiológica da sífilis congênita em um estado da Amazônia Ocidental. Trata-se de estudo transversal, de abordagem quantitativa tipo seccional, de dados secundários com coleta realizada no Departamento de Informações do Sistema Único de Saúde – DATASUS, tabulados a partir do TABNET. Os dados foram analisados pela estatística descritiva e inferencial afim de verificar as associações entre as variáveis de interesse. O comportamento da doença no estado apresenta uma tendência oscilante, onde no ano de 2018 ocorreu a maior parte dos casos (96), apresentando uma tendência de queda em 2021 com a notificação de (47) casos. Observou-se uma incidência geral de 4,8 casos para cada mil nascidos vivos, acima da meta estipulada pela Organização Pan Americana da Saúde. A maioria dos recém-nascidos diagnosticados com a doença, encontrava-se na faixa etária de até 6 dias de vida 365 (96%), do sexo feminino 192 (50%), da raça/cor da pele parda 325(85%), cujas mães possuíam o ensino fundamental incompleto 118 (31%). A maior parte das mães realizaram o acompanhamento pré-natal 322 (85%), cujo diagnóstico de sífilis materna ocorreu no momento do parto/curetagem 168 (44%), sendo que a maioria dos seus parceiros sexuais não foram tratados 285(75%). A maior parte dos recém-nascidos foram classificados como sífilis congênita recente 357 (94%), evoluindo em sua maioria para criança viva 331 (87%). A doença configura-se como um problema de saúde pública na região estudada e sugere-se que esteja associada a falhas na assistência pré-natal relacionadas ao diagnóstico oportuno e ao tratamento dos parceiros.
Efektivitas Larvasida Ekstrak Etanol Bunga Kecombrang (Etlingera elaitor) dan Daun Jambu Biji (Psidium guajava) terhadap Mortalitas Larva Aedes aegypti
Authors:   Universitas Perjuangan Tasikmalaya Indonesia, Bachtiar Kamiel Roesman , Rizkuloh Lina Rahmawati ,   Universitas Perjuangan Tasikmalaya Indonesia, Susanti Susanti ,   Universitas Perjuangan Tasikmalaya Indonesia, Endah Srie Rezeki Nur ,   Universitas Perjuangan Tasikmalaya Indonesia
Published: March 2023

Berbagai jenis tanaman di Indonesia telah diketahui mengandung senyawa bioaktif yang dapat dimanfaatkan sebagai biopestisida. DIantaranya adalah bunga kecombrang dan daun jambu biji yang dapat berfungsi sebagai larvasida. Tujuan dari penelitian ini adalah mengetahui efektivitas campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap mortalitas larva Aedes aegypti. Objek dalam penelitian ini adalah semua larva Aedes aegypti instar III yang berumur 3-4 hari Sampel total yang digunakan pada penelitian ini sebanyak 280 larva, yang di tentukan dengan teknik Purposive Sampling. Hasil penelitian menunjukkan ada pengaruh campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap kematian larva nyamuk Aedes aegypti. Semakin tinggi konsentrasi ekstrak bunga kecombrang dan daun jambu biji yang diberikan, semakin banyak pula terjadinya kematian pada larva Aedes aegypti. Angka kematian tertinggi sebesar 90% dengan label konsentrasi uji 5 pada konsentrasi 5000 ppm (komposisi 1250 ppm ekstrak bunga kecombrang dan 3.750 ppm ekstrak daun jambu biji). Hasil analisis probit menunjukkan nilai LC50 pada larva Aedes aegypti untuk formula campuran ekstrak bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidi guajava L.) adalah pada konsentrasi 2567,83 ppm
Deteksi populasi Cd3+Cd4+Cd25+Foxp3+ T-regulator pada Limpa Mencit Galur Balb/c dan Swiss-webster yang Mudah dan Cepat dengan Metode Flow Cytometry
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Tjahjono Yudy , Wijaya Hendy ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Esar Senny Yesery ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Caroline Caroline ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Jafet Nico ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Kusuma I Made Andika Bara ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Chrisantia Oryza ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Bhendy Maria Theresia Primadewy ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Palpialy Sindi Siska ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Soehadi Shellin ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Wilianto Yufita Ratnasari ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: March 2023

Sel T-regulator (Treg) memainkan peran kunci dalam mengendalikan autoimunitas, respon alergi, peradangan, dan respons terhadap infeksi. Sel T Cd4+ yang secara konstitutif mengekspresikan Cd25 dan protein forkhead 3 (Foxp3; yaitu, Cd3+Cd4+Cd25+Foxp3+) atau disebut juga sebagai Treg fungsional, telah terbukti memainkan peran utama dalam pemeliharaan toleransi dan homeostasis imun, sehingga deteksi Treg fungsional sangat penting dilakukan sebagai salah satu parameter imunomodulasi. Penelitian ini bertujuan untuk mendeteksi populasi sel Treg (Cd3+Cd4+Cd25+Foxp3+) pada organ limpa mencit galur Balb/c dan Swiss-webster dengan menggunakan metode yang mudah, cepat, serta terjangkau. Metode deteksi sel Treg dilakukan dengan cara isolasi organ limpa mencit Balb/c dan Swiss-webster kemudian dilakukan preparasi dan deteksi sel menggunakan instrumen flow cytometry. Hasil populasi sel Treg yang didapatkan berturut-turut pada mencit Balb/c dan Swiss-webster adalah 2,02 ± 0,36% dan 3,14 ± 1,64% dari total populasi yang dideteksi dengan hanya membutuhkan waktu 145 menit sejak pembedahan. Berdasarkan hasil tersebut dapat disimpulkan bahwa pengamatan populasi sel Treg pada splenosit mencit galur Balb/c dan Swiss-webster dengan flow cytometry dapat dilakukan dengan mudah dan praktis dengan pewarnaan kombinasi antibodi yang tertera pada manuskrip ini. Selain itu, metode pewarnaan yang tertera dapat digunakan sebagai salah satu acuan untuk mendeteksi imunomodulator pada berbagai model hewan coba yang menggunakan mencit galur Balb/c dan Swiss-webster, khususnya yang berhubungan dengan populasi sel Treg.
A review: Utilization of Herbal Medicines in Alzheimer's Disease from Three Plants in Indonesia
Authors:   Sekolah Tinggi Ilmu Kesehatan Medistra Indonesia, Reubun Yonathan Tri Atmodjo
Published: March 2023

Alzheimer's disease is a disease in which brain damage is characterized by a decrease in attention, memory, and personality. Personality changes often occur when sufferers become less spontaneous, more apathetic, and withdrawn from their environment. The use of chemical drugs derived from the synthesis of natural drugs is approved for clinical use for Alzheimer's patients. Synthesis from natural materials is carried out because of the many chemical compounds contained in plants which have various biological and pharmacological effects. As for the use of natural medicines that are efficacious as antioxidants, anticoagulants, and anti-inflammatories, they are targets in the prevention of Alzheimer's disease where from these effects they can inhibit the acetylcholinesterase enzyme that plays a role in neurotransmitter damage. This journal review aims to maximize the use of natural medicines that have antioxidant effects from plants such as turmeric (Curcuma longa L.), gotu kola (Centella asiatica L.) and Kelor leaves (Moringa oleifera Lam.) so that these three plants are expected to have an effect. potential in the prevention of Alzheimer's disease which will be discussed extensively.
Device Matters: Looking Beyond the Drug
Authors: Hesp Blair
Published: March 2023

Prof Helen Reddel opened the symposium by discussing the need to examine the modifiable nonpharmacological factors in the treatment of asthma and chronic obstructive pulmonary disease (COPD) that can be addressed to improve clinical outcomes. Dr Kai-Michael Beeh set the scene and discussed the need to review patient behaviour and drug delivery mechanisms to improve outcomes for patients with asthma and COPD. Dr John Haughney then discussed how patient preferences for inhalers can impact real-world outcomes. Prof Sinthia Bosnic-Anticevich outlined the challenges in learning and maintaining correct inhaler technique, while Prof Henry Chrystyn highlighted how inhaler design can help minimise the impact of inhaler errors on clinical outcomes. Prof Helen Reddel closed the session by bridging the gap between guidelines and clinical care, describing ways to incorporate regular checking and training of inhaler skills into a range of settings.
The meeting objectives were to look beyond drugs to the role of devices in optimising asthma and COPD management, to understand the impact of inhaler technique on treatment efficacy, to review how patient perspectives about their inhaler can impact on clinical outcomes, and to discuss how to implement current clinical guidelines on inhaler technique in day-to-day clinical care.
Efecto de la exposición a fotos editadas de Instagram en la imagen corporal: una replicación sistemática en jóvenes universitarias españolas
Authors: Muñoz Parralo María , Gómez Bujedo Jesús
Published: March 2023

La insatisfacción corporal está asociada a un mayor riesgo de suicidio y una peor calidad de vida. Esta puede generarse por comparación social y exposición a modelos corporales irreales por redes sociales. Este estudio es una replicación de una investigación de los Países Bajos (Kleemans et al., 2018) donde se analizaba la influencia de la exposición a fotos editadas de Instagram sobre la percepción de la imagen corporal en adolescentes. Se ha replicado el estudio con 104 jóvenes universitarias españolas que fueron expuestas de forma aleatoria a fotos editadas, fotos originales, o fotos de paisajes. Después se midió la percepción de la imagen corporal de las jóvenes. Respecto al artículo original se introdujo una tercera condición con fotos de paisajes, se midió la atención de las participantes y se realizó un cuestionario previo para evaluar la edición de las fotos estímulo. No se encontraron diferencias significativas entre los grupos. Se plantean las variables asociadas a la edad como influyentes en la relación entre la exposición a fotos en redes sociales y la percepción de la imagen corporal.
Delabelling multiple antibiotic allergy: Practical issues
Authors: Li Philip Hei , Thong Bernard Yu-Hor
Published: March 2023

With the growing incidence of multi-drug resistant organisms, delabelling incorrect antibiotic allergies has become an integral part of antimicrobial stewardship worldwide. For example, around 90% of penicillin allergy labels are found to be inaccurate following a full allergy work-up, which deprive patients the use of effective first-line penicillin antibiotics and increase the risk of antimicrobial resistance with the use of other extended spectrum non-penicillin antimicrobials. Significant numbers of adult and paediatric patients over time are labelled with multiple penicillin and non-penicillin antibiotic allergies often during inappropriate antimicrobial use, resulting in a label of “multiple antibiotic allergy”. In contrast to delabelling penicillin allergy where oral direct provocation tests can be used for low-risk, mild reactions, and sensitivity/specificity/positive and negative predictive values of skin tests have been demonstrated, diagnostic tests for multiple antibiotic allergy often require the use of a combination of in-vivo and in-vitro tests across different antimicrobial classes for evaluation. Shared decision making with patients and informed consent are also needed when prioritising which drugs to delabel first, balancing the risks, benefits of testing vs. interim use of alternative antibiotics. Similar to delabelling penicillin allergy, the cost-effectiveness of delabelling multiple drug allergies is unknown.
Sirtuin-3: A potential target for treating several types of brain injury
Authors: Yang Hongqiao , Zhou Zhaopeng , Liu Zhuanghua , Chen Junhui , Wang Yuhai
Published: March 2023

Sirtuin-3 (SIRT3) is responsible for maintaining mitochondrial homeostasis by deacetylating substrates in an NAD+-dependent manner. SIRT3, the primary deacetylase located in the mitochondria, controls cellular energy metabolism and the synthesis of essential biomolecules for cell survival. In recent years, increasing evidence has shown that SIRT3 is involved in several types of acute brain injury. In ischaemic stroke, subarachnoid haemorrhage, traumatic brain injury, and intracerebral haemorrhage, SIRT3 is closely related to mitochondrial homeostasis and with the mechanisms of pathophysiological processes such as neuroinflammation, oxidative stress, autophagy, and programmed cell death. As SIRT3 is the driver and regulator of a variety of pathophysiological processes, its molecular regulation is significant. In this paper, we review the role of SIRT3 in various types of brain injury and summarise SIRT3 molecular regulation. Numerous studies have demonstrated that SIRT3 plays a protective role in various types of brain injury. Here, we present the current research available on SIRT3 as a target for treating ischaemic stroke, subarachnoid haemorrhage, traumatic brain injury, thus highlighting the therapeutic potential of SIRT3 as a potent mediator of catastrophic brain injury. In addition, we have summarised the therapeutic drugs, compounds, natural extracts, peptides, physical stimuli, and other small molecules that may regulate SIRT3 to uncover additional brain-protective mechanisms of SIRT3, conduct further research, and provide more evidence for clinical transformation and drug development.
GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages
Authors: Jiang Ping , Chen Hongzhi , Feng Xiaojing , Xie Huiqi , Jiang Mengjie , Xu Danning , Tang Haoneng , Zhang Ningjie , Chen Jianlin , Zhang Lei , Tang Lingli
Published: March 2023

Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not been demonstrated. In this study, we found that C. trachomatis L2 infection of the mouse macrophage RAW 264.7 cells induced pyroptosis by monitoring the ultrastructural changes under transmission electron microscopy and the release of LDH and IL-1β. More importantly, this C. trachomatis-triggered pyroptosis with activation of caspase-1 and caspase-11 was also accompanied by gasdermin D (GSDMD) activation. Suppression of these two inflammatory caspases inhibited GSDMD activation. Interestingly, the C. trachomatis-triggered pyroptosis significantly inhibited the intracellular growth of C. trachomatis since inactivation of either GSDMD or caspase-1/11 significantly rescued infectious C. trachomatis yields, which suggests pyroptosis response can be utilized as an intrinsic mechanism to restrict C. trachomatis intracellular infection in addition to the well- documented extrinsic mechanisms by recruiting and enhancing inflammatory responses. This study may reveal novel targets for attenuating C. trachomatis infectivity and/or pathogenicity.
Phylogenetic relationships of Mycobacterium tuberculosis isolates in Poland: The emergence of Beijing genotype among multidrug-resistant cases
Authors: Bakuła Zofia , Marczak Mateusz , Bluszcz Agata , Proboszcz Małgorzata , Kościuch Justyna , Krenke Rafał , Stakėnas Petras , Mokrousov Igor , Jagielski Tomasz
Published: March 2023

Introduction

The epidemiological situation of tuberculosis (TB) in Poland urges for its continuous and scrupulous monitoring. The objective of this study was to explore the genetic diversity of multidrug-resistant (MDR) and drug-susceptible (DS) Mycobacterium tuberculosis isolates from Poland with a combination of spoligotyping and high-resolution mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) analysis. The results were placed in the Northern and Eastern Europe context.

Methods

The study included 89 (39 MDR and 50 DS) M. tuberculosis isolates collected from as many patients between 2018 and 2021 in Poland. The analysis was done using spoligotyping, and MIRU-VNTR typing at 24 standard loci. The data were compared to those available on Poland and neighbors and global M. tuberculosis datasets.

Results

The main identified families were Beijing (28.1%) and Haarlem (16.8%) while 34.8% of isolates were in the heterogeneous L4-unclassified group. Although the Beijing family was the most prevalent (61.5%) among MDR-TB cases, it accounted for only 2% of DS isolates. Among foreign-born patients, a higher ratio of MDR isolates were observed when compared with those who Poland-born (64.3% vs. 40%). Furthermore, all patients from the Former Soviet Union (FSU) countries were infected with MDR-TB.

Discussion

Whereas DS M. tuberculosis population in Poland is dominated by L4 isolates, MDR isolates are mostly of the Beijing genotype. The rise in the prevalence of the Beijing isolates in Poland, coupled with high proportion of the Beijing genotype among foreign-born TB patients may reflect an ongoing transmission of this family, imported to Poland mainly from FSU countries.
A contrastive study on the representation of “Made in China” in Chinese and U.S. newspapers
Authors: Wang Yingjie , Coler Matt , Redeker Gisela
Published: March 2023

The label “Made in China” (MIC) is an essential communication tool in the economic rise of China, marking its increasing prominence in international markets with labor-intensive products and also some knowledge-intensive products. This contrastive study adopts a corpus-based critical discourse analysis approach to illustrate how the major English-language newspapers in China and the United States represented MIC between 2006 and 2018. By categorizing the high-frequency noun lemmas in the two corpora of articles on MIC, we identify seven main topics that are shared by Chinese and U.S. newspapers, but differ in frequency and in trends across time. Through examining the collocates and concordances, we find that the overall attitude regarding MIC in U.S. newspapers is more negative than that in Chinese newspapers, where the dominant attitude shifts from negativity to positivity in 2013, while negativity dominates throughout in U.S. newspapers. We argue that the ideological differences evidenced in language patterns reflect the two countries' conflicting economic interests. This study makes a contribution to the existing literature on MIC by aligning with the prior findings of a negative portray of MIC around 2007, primarily due to product safety issues, and addresses a gap by examining the repidly evolving representation of MIC in the 2010s, which is characterized by the intensified trade relations between the two countries.