bluuebunny/crossref_metadata_2025 huggingface dataset:
The Legal Development of Public Control in Education and Science
Authors:   Rector of the Griboyedov Institute of International Law and Economics, Head of the Department of Legal Bases of Management of the Moscow State Institute of International Relations (University) of the Ministry of Foreign Affairs of the Russian Federation (MGIMO University), Corresponding Member of the Russian Academy of Education (RAE), Honored Lawyer of the Russian Federation, LL.D., Professor, Grib Vladislav V.
Published: March 2022

The article analyzes subjects and forms of public control in science and education, the author singles out among such subjects the Public Chamber of the Russian Federation and public chambers of the constituent entities of the Russian Federation, public councils under federal executive authorities and public councils for the independent evaluation of quality of educational activities of organizations as well as public organizations and public supervisors. The following public control forms are characteristic of education: pedagogical examination of bills; independent evaluation of quality of education; creation of ratings in education; public accreditation of educational institutions; professional and public accreditation of educational programs; monitoring in the system of education; participation in management of educational institutions.
The Concept of the Legal Doctrine of Sustainable Complex Development of Rural Settlements of the Russian Federation
Authors:   Associate Professor of the Dostoevsky Omsk State University, PhD (Law), Associate Professor, Afanasyev Aleksandr A.
Published: March 2022

The article analyzes the current State of federal and regional legislation, municipal legal acts in the implementation of the State policy of sustainable integrated social and economic development of rural territories of the Russian Federation. The author comes to the conclusion that the current legal norms and the mechanism of legal regulation do not ensure the achievement of the stated goals and objectives for the development of the village. Key ideas, principles and directions for their improvement are formulated. The legal analysis, conclusions and proposals for changes to the organizational and legal mechanism for ensuring sustainable integrated development of rural settlements in the Russian Federation are presented in the form of a concept of legal doctrine.
Engagement of Citizens in the Government of a State: Expediency and Limits (Problem Setting)
Authors:   Head of the Department of Financial Law and Customs of the Law Institute of the Vladimir State University (VlSU), PhD (Law), Associate Professor, Pogodina Irina V.
Published: March 2022

New technologies have led to the emergence of new forms of citizens’ participation in government, including in rule-making. So-called “co-management” is expanding at an unprecedented rate. Digitalization of civic participation not only facilitates access to more information, but also makes the processes of interaction between the state and citizens fast, relatively cheap, and also promotes political and legal discussions about the limits of such participation. On the one hand, the participation of citizens in public administration is a necessary, inevitable process that legitimizes power, one of the hallmarks and instruments of democracy. However, on the other hand, the involvement of too many participants in public administration processes has a number of disadvantages.
Sağlık Göstergeleri ile İşgücü Verimliği İlişki Yapısının Kanonik Korelasyon Analizi
Authors: Nurdoğan Ali Kemal , Bayar Hilal Tuğçe
Published: March 2022

Çalışmanın amacı sağlık göstergeleri ile işgücü verimliliği arasındaki ilişkiyi incelemektir. Çalışmada, Avrupa Birliği üyesi yirmi altı ülkeye ait sağlık ve işgücü verimliliği verileri kullanılarak sağlık göstergeleri ve işgücü verimliliği değişken setleri arasındaki ilişki çok değişkenli istatistiksel analiz tekniği kanonik korelasyon analizi yöntemi ile incelenmiştir. Kanonik korelasyon analizine başlanmadan önce veri seti ve varsayımlar test edilmiş ve değişkenlerin çok değişkenli normal dağılım gösterdiği görülmüştür. Yapılan kanonik korelasyon analizi sonucunda elde edilen dört adet kanonik korelasyon fonksiyonundan birinci ve ikinci kanonik değişken istatistiksel olarak anlamlı bulunmuştur. Birinci kanonik korelasyon .895 değeri ile iki veri setinin arasında yüksek dereceli bir ilişki olduğunu göstermektedir. İkinci kanonik korelasyon .690 değeri ile iki veri setinin arasında orta dereceli bir ilişki olduğunu göstermektedir. Birinci kanonik değişken çiftine (U1V1) en fazla katkı sağlayan değişkenler Kronik Hastalık ve Çalışılan Saat Başına İşgücü Maliyet değişkenleridir. İkinci kanonik değişken çiftine (U2V2) en fazla katkı sağlayan değişkenler Kişi Başı Sağlık Harcaması ve Birim İşçilik Maliyetleri-Çalışma Saatine Göre değişkenleridir. Elde edilen bulgular değerlendirildiğinde sağlık göstergeleri ile işgücü verimliliği arasında anlamlı ve pozitif yönlü yüksek bir ilişki olduğu sonucuna ulaşılmıştır.
Anahtar Kelimeler: Sağlık, İşgücü, İşgücü Verimliliği
JEL Sınıflandırması: I19, J10, J24
The Analysis of Structural Changes in the Reserves of the Bank of England
Authors: Çetin Mehmet
Published: March 2022

Bank of England, one of the leading examples of modern banking, has been established at the end of the 17th century. Economic and social turmoils and wars that broke up in the first half of the 19th century have led to a serious debate between the Currency School and Banking School regarding the primary function of BoE. The Bank Charter Act dated 1844 has been enacted to eliminate the ongoing instabilities in the British economy. The act was suspended in 1847, 1857, and 1866 because of the developments. In this study, the effects of economic and non-economic developments on the Bank’s reserves are investigated using the structural breakpoint tests for the period between 1844 and 1866. To detect the presence of any regime shifts in both series mean and variance, the Bai and Perron and ICSS algorithm procedures were employed. The findings of the study reveal the effects of domestic and foreign military, political and economic developments directly affecting the UK, on the reserves of the Bank.
Key Words: Bank of England, The Bank Charter Act of 1844, Structural breaks.
JEL Classification: N23, E58, E52
Discriminating Between the Side Effects of the Firm Behavior: Did We Import COVID-19?
Authors: Aydoğan Yiğit
Published: March 2022

Early COVID-19 presence and related deaths in Turkish cities can be explained by their international trade volume. Trade with China has a higher impact on the pandemic against the total international trade of cities. The ordering between imports, exports and total trade with China varies depending on the stage of the pandemic. As the China were sealed off by many countries, continuing international trade with the country has increasing impact on the case numbers.
Key Words: COVID-19, City-level Data Analysis, International Trade.
JEL Classification: C21, R15, F14, F68
Are Standard COVID-19 Isolation Protocols Appropriate in Haemodialysis Units? A Description of a Novel SARSCoV-2 Coronavirus Outbreak in a Haemodialysis Unit in Johannesburg, South Africa
Authors: Davies M. , Cassimjee Z. , Chiba S. , Dayal C. , Motala N.
Published: March 2022

Background: Recipients of outpatient haemodialysis are at an increased risk of acquiring severe SARS-CoV-2 infection. Isolation of infected patients reduces in-centre transmission, but protocols extrapolated from the general population may not be applicable in this setting. We describe the kinetics of an outbreak in a tertiary dialysis centre in Johannesburg, South Africa, to suggest an appropriate isolation strategy.

Methods: Retrospective analysis of a clinical database employed to facilitate isolation of exposed and infected patients was undertaken. Modes of transmission, incubation and recovery periods in patients developing SARS-CoV-2 infection were assessed. The effects of factors modulating immune function on incubation and recovery periods were modelled using sigma-restricted partial least squares linear regression. Severity of infection and the outcomes thereof were described to assess the efficacy of the isolation protocols employed.

Results: SARS-CoV-2 infection was diagnosed in 24.7% of patients receiving outpatient haemodialysis. Contact with an infected healthcare worker was the leading indication for surveillance swabbing in this cohort (49.12%). Forty per cent of all positive cases had antecedent contact with an infected healthcare worker, and possible patient-to-patient transmission occurred in one case. The median time to the diagnosis of infection following known exposure was 16.5 days. Comorbid diabetes and increasing dialysis vintage were associated with a shorter incubation period. The median time to clearance of infection was 33.5 days. The clinical disease severity prolonged the recovery period. No patient required mechanical ventilation, and there were no deaths during the study period.

Conclusion: Haemodialysis patients manifest prolonged incubation and recovery periods. Serial monitoring with RT-PCR swabs may be required to ensure effective isolation.
Korekta rocznego zeznania podatkowego w podatku dochodowym od osób fizycznych – wybrane zagadnienia
Authors: Gródecka Magdalena
Published: March 2022

Konstrukcja podatku dochodowego od osób fizycznych oparta jest na tzw. samoobliczeniu, a więc złożeniu przez podatnika stosownej deklaracji podatkowej. Obowiązkowi złożenia przez podatnika rocznego zeznania podatkowego towarzyszy możliwość korygowania tego rodzaju deklaracji, w szczególności z uwagi na błędy formalne (np. w zakresie danych identyfikujących składającego) lub rachunkowe. Korekta deklaracji może wiązać się zarówno ze zmniejszeniem kwoty do zapłaty (nadpłata), jak i z koniecznością zwiększenia kwoty zobowiązania. W przypadku wykazania zobowiązania podatkowego w kwocie wyższej niż wskazana w poprzedniej deklaracji podatnik ma obowiązek obliczenia i uiszczenia nie tylko kwoty zaległości, ale również odsetek od tej zaległości. Korygowanie zeznania rocznego w podatku dochodowym od osób fizycznych co do zasady stanowi uprawnienie podatnika, choć – w przypadku spełnienia przesłanek z art. 274 ustawy z dnia 29 sierpnia 1997 r. – Ordynacja podatkowa – organ podatkowy może zwrócić się do składającego deklarację o jej skorygowanie bądź dokonać stosownej korekty z urzędu. Skorygowanie deklaracji powoduje, że deklaracja pierwotna traci „byt prawny” i obowiązuje wersja skorygowana.1 Niniejszy artykuł przybliża problematykę dopuszczalności i skutków złożenia korekty rocznego zeznania podatkowego w podatku dochodowym od osób fizycznych. Mając na względzie to, że nieograniczony obowiązek podatkowy w podatku dochodowym od osób fizycznych dotyczy osób fizycznych mających miejsce zamieszkania na terytorium Rzeczypospolitej Polskiej, postulować należy zwiększenie przejrzystości analizowanych przepisów.
Nowy (bez)Ład w opodatkowaniu najmu nieruchomości
Authors: Jaśniewicz Maciej
Published: March 2022

W pakiecie zmian podatkowych Nowego Ładu zawarto nowe, wręcz rewolucyjne zmiany dotyczące opodatkowania podatkiem dochodowym przychodów z najmu. Dotyczą one wyłączenia możliwości opodatkowania przychodów z tego źródła na zasadach ogólnych przez osoby fizyczne nieprowadzące działalności gospodarczej oraz zakazu amortyzacji nieruchomości mieszkalnych przez przedsiębiorców. W artykule przedstawiono rys dotyczący dotychczasowych zasad opodatkowania przychodów z najmu oraz zaprezentowano uchwalone obecnie zmiany, które w dużej części mają wejść w życie od 2023 r. Poddano je także krytycznej ocenie, gdyż przede wszystkim stanowią one odwrót od koncepcji powszechnego podatku dochodowego. Ponadto są naruszeniem konstytucyjnych zasad ochrony praw nabytych i ochrony interesów w toku. Pozostają także w kolizji z wcześniej wprowadzonymi zmianami ustawodawczymi, które miały zachęcać przedsiębiorców do inwestycji w rynek nieruchomości mieszkaniowych przeznaczonych na wynajem. W podsumowaniu wskazano na faktyczne intencje ustawodawcy, które w rzeczywistości nie mają na celu porządkowania systemu opodatkowania dochodów osobistych.
Krajowa Administracja Skarbowa – reasumpcja
Authors: Nowak Ireneusz
Published: March 2022

Artykuł poświęcony jest procesowi konsolidacji administracji podatkowej, skarbowej i celnej w Krajową Administrację Skarbową, począwszy od prac podjętych w 2007 r., a kończąc na uchwalonych w tym zakresie aktach prawnych z 2016 r. W publikacji podjęto próbę ustalenia, jakie cele przyświecały ustawodawcy, a raczej sui generis „ghostwriterom” z Ministerstwa Finansów, ponieważ tam właśnie powstały projekty wspomnianych tekstów prawnych, które następnie zostały przedstawione jako projekty poselskie. W powyższym celu badawczym autor wykorzystał materiał empiryczny pochodzący od Ministra Finansów, Szefa Krajowej Administracji Skarbowej i jego zastępcy, z raportów Najwyższej Izby Kontroli oraz poglądów doktryny i stanowiska judykatury.
Przemiany poziomu dzietności w obecnych miastach wojewódzkich w Polsce w latach 1983–2020
Authors: Szukalski Piotr
Published: March 2022

Przełom XX i XXI w. to okres znaczących zmian w sferze zachowań rozrodczych w Polsce. Celem artykułu jest prezentacja w szerszym kontekście przemian zachodzących na bazie współczynnika dzietności (płodności całkowitej) w miastach będących aktualnie stolicami województw. Przeprowadzona analiza wykazała podobieństwo występujących zmian, choć równocześnie utrzymywanie się grup miast pionierów (największe miasta) i miast, w których – w stosunku do pionierów – występuje pewne opóźnienie względem obserwowanych tendencji przemian demograficznych (mniejsze ośrodki, ulokowane zwłaszcza we wschodniej części kraju).
Implementación de metodologías analíticas para la caracterización de aguas geotérmicas para aplicación en usos directos
Authors: Robles-Chaves Diana , Arias-Molina Olman Alberto
Published: March 2022

En Costa Rica se han identificado importantes campos geotermales con temperaturas inferiores a los 150 °C, que han sido poco explorados, y su uso es prácticamente exclusivo para baños termales; dejándose de lado importantes aplicaciones en usos directos donde se utiliza el calor de este recurso, para sistemas de climatización, acuicultura, deshidratación, entre otros. En esta investigación, se seleccionaron seis sitios de agua geotérmica en la zona de Cartago con temperaturas superficiales en un rango entre (43 - 61) °C, y se determinó que la totalidad de las muestras son clasificadas como aguas salobres con una composición predominante de tipo (HCO3- __ Na+) o (SO42- __ Na+), las cuales podrían presentar problemas de corrosión o incrustación. Se estimó que el geotermómetro de SiO2 es el más adecuado para estimar las temperaturas del reservorio las cuales se encuentran en el rango entre (75 - 83) °C. La validez de las metodologías analíticas empleadas fue demostrada realizando enriquecimientos con material de referencia en esta matriz, obteniéndose porcentajes de recuperación entre (85-119)%.
Travma Mağdurlarına Yönelik Grup Müdahaleleri
Authors: ÇAMAŞ Gözde , ANAYURT Ayşegül
Published: March 2022

Travmatik deneyimlerin yaşanma sıklığının artması, travma mağduru kişi sayısında artışa neden olmaktadır. Görülen bu artış, psikolojik destek sürecini de beraberinde getirmektedir. Travmatik deneyimlere maruz kaldıktan kısa bir süre sonra ise birçok bireyin travma sonrası stres bozukluğu (TSSB) yaşadığı gözlenmektedir. Travmatik deneyimler ve TSSB ile başa çıkma konusunda travma mağdurlarına hem bireysel hem de grupla psikolojik müdahaleler uygulanabilmektedir. Grupla uygulanan müdahalelerin çeşitli avantajları düşünüldüğünde ise son yıllarda tercih edilen yaklaşımlardan biri olduğu görülmektedir. Bu derleme makalesi ile alanyazında son yıllarda ön plana çıkan travma mağdurlarına uygulanan grup müdahaleleri ve bu müdahalelerin etkililiği ele alınmak istenmiştir.
Anormal Kavramına Ruh Sağlığı Üzerinden Bir Bakış
Authors: ÖZEN Yener , TAŞDEMİR Oğuzhan
Published: March 2022

Bu çalışmada anormal davranış çerçevesinde ruh sağlığının tanımı, anormal kavramının tanımı, bireylerin nasıl ve hangi kriterlere göre normal ve anormal olarak ele alındığı, geçmişte anormal kavramına hangi statülerin verildiği, anormal davranış gösteren bireylerin tedavilerinin nasıl yapıldığı, ruhsal bozuklukların tanımı ve ölçütlerinin neler olduğu ele alınmıştır. Bu bağlamda alanyazında ön plana çıkan bozuklukların ayırt edici noktaları ile akıl sağlığı noktasındaki gerçekler ve kurgulara değinilmiştir. Bununla birlikte anormal davranış ile bireyin iyi oluşunu inceleyen yaklaşımlar arasında ilişki kurulmasının ve tedavi noktasında kültüre özgü varyasyonların göz önünde bulundurulmasının önemli olduğuna dikkat çekilmiştir. Alanyazından hareketle hem uygulayıcılar hem de araştırmacılar için çeşitli öneriler sunulmuştur.
Pengaruh Arus Kas Operasi Dan Laba Akuntansi Terhadap Return Saham Pada Perusahaan LQ45 Yang Terdaftar Di Bursa Efek Indonesia Tahun 2018-2020
Authors: Rivandi Muhammad , Lestari Nur Hikmah
Published: March 2022

Return saham merupakan keuntungan yang diperoleh dari kepemilikan saham investor atas investasi yang dilakukan. Tujuan dalam penelitian ini yaitu untuk mengetahui pengaruh arus kas operasi terhadap return saham perusahaan LQ45 yang terdaftar di Bursa Efek Indonesia tahun 2018-2020.Populasi penelitian adalah semua perusahaan LQ45 yang terdaftar di BEI. Sampel dalam penelitian ini sebanyak 23 perusahaan yang dipilih dengan metode purposive sampling. Metode analisis yang digunakan adalah metode regresi panel. Berdasarkan hipotesis hasil penelitian menunjukkan bahwa arus kas operasi tidak berpengaruh terhadap return saham dan laba akuntansi berpengaruh positif dan signifikan terhadap return saham
Energy Unit Expenses of Trains with Asynchronous Electric Drive
Authors: Shlendov Igor'
Published: March 2022

Objective: The assessment of energy effectiveness of traction drives for carriages of rolling stock models 81-765/766/767 and 81-556/557/558 (“NEVA”) from various producers and drafting technical requirements for drive electric equipment. Stock 81-765/766/767 uses asynchronous engine of 170 kW wattage and 43 Hz field rated frequency, 81-556/557/558 — 167 kW with 70 Hz rated frequency. Methods: The comparative analysis of drive energy indicators of trains with asynchronous electric drives has been accomplished in accordance with the calculation methodology. Measuring section was set in accordance with GOST P 50850-96. There are defined the assumptions at motion of rolling stock with equal maximal acceleration in a runaway and maximal deceleration in a braking and constant deceleration in a run-out. Maximal acceleration and deceleration were calculated incompliance adhesion set coefficient, grip weight (mass of motor cars) and moment of inertia. The calculation by method of analytical integration of motion differential equation was held on runaway five intervals. Initial technical data of trains with rated load as well as calculated indicators at train motion on measuring section were accepted. Diagrams of train motion on section were built and comparative analysis of characteristics of stock carriage models 81-765/766/767 and 81-556/557/558 (“NEVA”) was pursued. Results: It was established during the comparison that engine overload by torque on shaft is the same with 1.5 coefficient to rated torque. Stocks have significantly different indicators as by unit expenses as well as by motion dynamics. It’s been also established that for to minimize energy costs for traction it’s required to develop maximally allowable deceleration at braking and maximally allowable acceleration at runaway. Practical importance: The necessity of entry into Technical Task for new rolling stock of the requirement on stock check on runaway possibility with maximal set acceleration.
Dependence of corrosion activity of aquatic-petroleum mixtures on characteristics of aquatic environments
Authors: Homenko Anna , Gomelya Mykola , Мakarenko Iryna , Shabliy Tetiana
Published: March 2022

The processes of metal corrosion in water-oil mixtures depending on the level of water mineralization, reaction of the environment, and ratio between the volumes of oil and aqueous solutions at temperatures of 20 oC and 80 oC were studied. It is shown that the corrosiveness of the medium against metals becomes higher with increasing level of water mineralization and acidic content with decreasing pH of the medium and increasing temperature. The corrosion rate of metals is significantly reduced in the presence of oil. Increase in the oil content in water-oil mixtures has little effect on the corrosion rate of metals. Increase in the hardness of water in the presence of acetic acid does not reduce the corrosion rate of metals and, in some cases, there is an increase in the corrosion activity of water with increasing hardness.
Adaptation of EORTC QLQ-INFO25 Questionnaire to Turkish in Cancer Patients: A Validity and Reliability Study
Authors: Çakır Pınar Atak , KALLİ Büşra , MUTLUAY Fatma , ETİ Serkan
Published: March 2022

Background
The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life (QL) Group has developed the EORTC INFO module to evaluate information received by cancer patients. The aim of this study is to examine the validity and reliability of the Turkish version of the EORTC QLQ-INFO25 scale.
Methods
Turkish version of the EORTC QLQ-INFO25, EORTC QLQ-C30 and EORTC IN-PATSAT32 questionnaires were applied to 197 patients at different stages of the disease and in the chemotherapy, radiotherapy, and surgery stages of the treatment. For the reliability and validity of the questionnaire, Cronbach's alpha, inter- scale correlation and factor analysis were used.
Results
As a result of validity analysis; according to factor analysis findings, the explained variance of the scale was found to be sufficient with 66.68%. As a result of reliability analysis, Cronbach’s alpha coefficient was 0.92 for the entire questionnaire, which showed that the reliability of the scale was high. The correlation of each item with its own scale (Rho ≥ 0.6) represents a high convergent validity. The selected questions of EORTC IN-PATSAT32 and Pearson correlation coefficients between the 4 determined areas and 2 items of EORTC QLQ-INFO25 showed high convergent validity. Low correlation (Spearman Rho < 0.2) was found between the EORTC-QLQ-C30 questionnaire and the different areas of the EORTC QLQ-INFO25 questionnaire, indicating that the two questionnaires measured different concepts.
Conclusions
It was determined that the Turkish version of the EORTC QLQ-INFO25 scale is a valid, reliable tool for measuring the knowledge level of cancer patients and can be used in Turkish society.
The relationship between genetic variation of genes in RLR-MAVS and cGAS-STING signaling pathway and other genes with HBV intrauterine transmission
Authors: Liu Suihan , Wu Rufang , Peng Songxu , Zhang Xukuan , Du Yukai
Published: March 2022

Background
Hepatitis B virus is a major public health problem worldwide. The genetic susceptibility of HBV intrauterine transmission has also attracted extensive attention from researchers. We explored the relationship between genetic variation of genes in RLR-MAVS and cGAS-STING signaling pathway and other genes with intrauterine transmission.
Methods
A case-control study was performed on HBsAg-positive pregnant women who delivered from January 2013 to August 2017 at Wuhan Medical Care Center for Women and Children, Wuhan, China. In total, 1356 infants born from those women were included, and there were 107 infants with HBV intrauterine infection. RLR-MAVS and cGAS-STING signaling pathway-related genes and IL10, IL12A, IL12B, TLR3, TLR9, TNFSF14 were selected as candidates. MassARRAY gene detection system was used for genotyping. Multivariate unconditional logistic regression, cumulative effect analysis, and multifactor dimensionality reduction were used for statistical analysis.
Result
The risk of HBV intrauterine transmission in infants with rs28413168 CC/CG genotype in INTS10 gene increased by 100% compared with those with GG genotype, and GG/AG genotype in MB21D1 gene was significantly lower than that in infants with AA genotype. Compared with the rs1800872 CC genotype in IL10 gene, the risk of HBV intrauterine transmission in infants with AA genotype was significantly increased. Compared with the rs3775291 CT/CC genotype in TLR3 gene, infants with TT genotype had significantly increased risk of HBV intrauterine transmission. The risk of HBV intrauterine transmission in infants with 5–8 risk alleles was 4.34 times higher than that in those with 0–2 risk alleles after adjustment for the age of delivery, parity, HBeAg, HBV DNA.
Conclusions
The genetic polymorphisms of INTS10 rs28413168, MB21D1 rs311678, IL10 rs1800872, TLR3 rs3775291 are closely related to the susceptibility of HBV intrauterine transmission. The more risk alleles an infant carries, the higher the risk of HBV intrauterine transmission.
Piezoelectric inkjet printing of tyrosinase (polyphenol oxidase) enzyme on atmospheric plasma treated polyamide fabric
Authors: Biswas Tuser T. , Yu Junchun , Nierstrasz Vincent A.
Published: March 2022

Tyrosinase enzyme was digitally printed on plasma pretreated polyamide-6,6 fabric using several sustainable technologies. Ink containing carboxymethyl cellulose was found to be the most suitable viscosity modifier for this enzyme. Before and after being deposited on the fabric surface, the printed inks retained enzyme activity of 69% and 60%, respectively, compared to activity prior printing process. A good number of the printed enzyme was found to be strongly adsorbed on the fabric surface even after several rinsing cycles due to surface activation by plasma treatment. Rinsed out fabrics retained a maximum activity of 34% resulting from the well-adsorbed enzymes. The activity of tyrosinase on printed fabrics was more stable than ink solution for at least sixty days. Effects of pH, temperature and enzyme kinetics on ink solution and printed fabrics were assessed. Tyrosinase printed synthetic fabrics can be utilized for a range of applications from biosensing and wastewater treatment to cultural heritage works.
Ligands tris(2-pyridylmethyl)amine with nitrile group in α-substituted and the corresponding FeCl2 complexes
Authors: Thallaj Nasser
Published: March 2022

We have synthesized the mono, bis and tris nitrile at the α position ligands in the tris(2-pyridylmethyl) amine (TPA) series, respectively CNTPA, (CN)2TPA and (CN)3TPA. Nitrile at the α position of these nitrogen-containing tripods shifts the oxidation potential of the ligand by comparison with the TPA ligand, it is observed that the oxidation potentials of the ligands increase regularly with the number of nitrile groups. For each group added, the oxidation potential is increased by an average of 110mV / ECS. This reflects the strong electron-withdrawing effect of the nitrile groups.. The crystal structure analysis of the dichloroferrous complexes with CNTPA and (CN)2TPA reveals that the iron lies in a distorted octahedral geometry comparable to that already found in TPAFeCl2. All spectroscopic data indicate that the geometry is retained in solution. These three isostructural complexes all react with molecular dioxygen to yield µ-oxo diferric complexes as stable compounds. Upon reduction, all µ-oxo diferric complexes convert back into the starting ferrous species. The oxygenation reaction parallels the well known formation of µ-oxo derivatives from dioxygen in chemistry of porphyrins reported almost three decades ago. The crystal structure analysis is reported for each of these three µ-oxo compounds. With TPA, a symmetrical structure is obtained for a dicationic compound, the tripod coordinating in the (κ4-N) coordination mode. With CNTPA, the compound is a neutral µ-oxo di-ferric complex. When oxygenation is carried out on the (CN)2TPA complex, a neutral asymmetrical compound is obtained. The striking point within the series of ferrous precursors is the effect of the ligand on the kinetics of oxygenation of the complexes. Whereas the parent complex undergo full oxygenation over 14 hours, the mono nitrile ligand provides a complex that has fully reacted over 14 hours, the reaction time being only 2 hours for the complex with the dinitriles ligand,and for trinitriles ligand it will tack 30min. Thus electron-deficiency ( Lewis acidity at the metal centre) seems to govern the kinetics of oxygenation. This strongly suggests coordination of the dioxygen as an initial step in the process leading to formation of µ-oxo diferric compounds, by contrast with un unlikely outer sphere reduction of dioxygen, that generally occurs at very negative potentials. Finally, we report that cyclohexane is catalytically converted into cyclohexanone when reacted with dioxygen in the presence of zinc amalgam, and that the conversion rate also parallels the Lewis acidity at the metal center, with the best rate obtained for with (CN)2TPAFeCl2.
The Relationship Between Cumulative Ecological Risk and Adolescent Cyberbullying: the Mediating Effects of Rumination and Cybervictimization
Authors: Liu Yifan , Gan Xiong , Liu Rong , Jin Xin , Zhu Congshu
Published: March 2022

This study explored the mechanism of cyberbullying, the independent mediating effect of rumination and cybervictimization respectively, and the chain mediation effect of rumination and cybervictimization based on the theory of cumulating ecological risk. 1510 junior high school students (mean age:15.2, standard deviation: 1.41, ag range: 13–17) were adopted to fill with the Cyberbullying/Cybervictimization Questionnaire, the Cumulative Ecological Risk Scale, the Rumination Scale. And we tested the correlation among the four variables, namely rumination, cybervictimization, cumulative risk, and cyberbullying. The chain mediating effect of rumination and cybervictimization between cumulative ecological risk and cyberbullying was modelled as well. The results revealed that: (1) cumulative ecological risk had a significant positive predictive effect on cyberbullying behaviour with controlling for grade and gender. (2) Cybervictimization mediated the relationship between cumulative ecological risk and cyberbullying; (3) Rumination and cyber-victimization play a chain mediating role in the relationship between cumulative ecological risk and cyberbullying.
CD44+/CD24-Flow Cytometry and Immunohistochemistry on Therapy Response to the Administration of Chemotherapy in Ovarian Cancer
Authors: Sihombing Unedo Hence Markus , Andrijono Andrijono , Purwoto Gatot , Gandamihardja Supriadi , Harahap Alida R. , Rustamadji Primariadewi , Kekalih Aria , Widyawati Retno , Fuady Dzicky Rifqi
Published: March 2022

Ovarian cancer is one of the deadliest women’s cancers. There is much chemoresistance to ovarian cancer standard therapy. CD44+/CD24− have an essential role in developing chemoresistance and poor prognosis for the patients. We aimed to study CD44+/CD24− relationship with ovarian cancer chemoresistance and its ability to predict chemoresistance. This study is an ambispective cohort study of 32 people in each group at the Obstetrics-gynecology and pathology Department of Cipto Mangunkusumo, Tarakan, Dharmais, and Fatmawati Hospital. All suspected ovarian cancer patients will undergo cytoreductive debulking and histopathological examination. Chemotherapy will be given for six series followed by six months of observation. We determine therapy response with the RECIST Criteria (Response Criteria in Solid Tumours) then classify it into chemo-resistant or chemo-sensitive groups. Our study is the first study examining CD44+/CD24− in ovarian cancer from flow cytometry blood test and directly from ovarian cancer tissue by double immunohistochemistry. We found a significant relationship between increased levels of CD44+/CD24− expression (p < 0,05) with chemoresistance of ovarian cancer from both studies while immunohistochemistry has a better multivariate analysis result. Both studies indicate that CD44+/CD24− was significantly associated with ovarian cancer chemoresistance and CD44+/CD24− immunohistochemistry is a better predictor.
Evaluation of change in the peat soil properties affected by different fire severities
Authors: Fulazzaky Mohamad Ali , Ismail Ibrahim , Harlen Harlen , Sukendi Sukendi , Roestamy Martin , Siregar Yusni Ikhwan
Published: March 2022

Tropical peatland ecosystems of Indonesia provide direct economic benefits to the local communities and act to maintain the local weather patterns. The impact of burning tropical peat swamp forests of land clearing for palm oil plantations can have significant consequences on the change in the characteristics of peat soil. The aim of this study was to determine the physical, chemical, and biological properties of the peat soils by the field and laboratory testing and analysis for understanding a change in the nature and characteristics of the peatlands at four locations in the Pelalawan regency of Riau province. The results showed that the effect of burning peat swamp forests can lead to a change in the physical, chemical, and biological properties of the peat soils. Soil permeability and soil microbial population can significantly decrease with increasing of the fire severity. The effect of different fire severities on the characteristics of peat soil are verified to contribute to advanced management of the tropical peatland in the future.
Multi-tissue metabolomic profiling reveals potential biomarkers of cocoon yield in silkworms (Bombyx mori) fed formula feed versus mulberry leaves
Authors: Wu Xuehui , Chen Xuedong , Ye Aihong , He Ruimin , Zhang Meihua , Pan Meiliang , Jin Feng , Ma Huanyan , Cao Jinru , Zhou Wenlin
Published: March 2022

Background
Use of formula feed (FF) for silkworms for all instars, has promoted transformation and progress in traditional sericulture. However, the cocoon yield of FF silkworms has failed to reach that of silkworms fed mulberry leaves (ML). The biological mechanisms underlying this phenomenon have not been well described. This study aimed to identify potential biomarkers and metabolic mechanisms relating to the poor cocoon yield of FF silkworms. In this study, silkworms received treatments of either ML (ML group) or FF (FF group) for all instars. At the 3rd day of the 5th instar, the hemolymph, midgut and posterior silk gland were collected for the metabolome profiles detection. The remaining silkworms were fed ML or FF until cocooning for investigation.
Results
The whole cocoon yield (WCY) was significantly higher in the FF group than the ML group (P < 0.05), whereas the cocoon shell weight (CSW) and cocoon shell rate (CSR) were significantly lower in the FF group (P < 0.05). A total of 867, 845 and 831 metabolites were qualified and quantified in the hemolymph, midgut and posterior silk gland of the FF silkworms, respectively. Correspondingly, 833, 789 and 730 metabolites were quantified in above three tissues of the ML group. Further, 249, 230 and 304 significantly different metabolites (SDMs) were identified in the hemolymph, midgut and posterior silk gland between the FF and ML group, respectively. Eleven metabolic pathways enriched by the SDMs were mutual among the three tissues. Among them, cysteine and methionine metabolism, arginine biosynthesis, and arginine and proline metabolism were the top three pathways with the highest impact value in the posterior silk gland. Six biomarkers were obtained through biomarker analysis and Pearson correlation calculation. Among them, homocitrulline, glycitein, valyl-threonine, propyl gallate and 3-amino-2,3-dihydrobenzoic acid were positively correlated with WCY, but negatively correlated with CSW and CSR (P < 0.05). An opposite correlation pattern was observed between 3-dimethylallyl-4-hydroxyphenylpyruvate and the three cocoon performance traits.
Conclusions
Overall, three key metabolic pathways and six biomarkers associated with cocoon yield were interpreted, and should provide directions for formula feed optimization in factory-raised silkworms.
Faculty perceptions and use of e-learning resources for medical education and future predictions: a cross sectional study
Authors: Kim Kyong-Jee , Kim Giwoon , Kang Youngjoon
Published: March 2022

Background: The remarkable increase in the use of online teaching and learning in medical education caused by the COVID-19 pandemic, research on faculties’ perceptions and the use of e-learning resources has been scant. This study aims to investigate the use of e-learning resources by medical faculties and explore future directions in using and sharing of such resources.Methods: This descriptive study was conducted on full-time faculty members who were registered users of the e-learning portal of the consortium of 36 Korean medical schools. Participants were invited to an online survey containing 45 items that addressed their perceptions and use of e-learning resources, and their predictions of future use. Descriptive analysis and reliability analysis were conducted as well as a thematic analysis of qualitative data.Results: Ninety faculty members from 31 medical schools returned the questionnaires. Respondents had positive perceptions of e-learning resources and predicted that the use of such resources would become more popular. However, only a half of the respondents used e-learning resources for teaching, and they pointed out several barriers to the use and sharing of the resources. Furthermore, our findings suggest future directions in terms of content areas that we should focus on creating and sharing resources, namely, multimedia assessment items, clinical videos, virtual patients, sharing best video lectures across institutions, and Massive Open Online Courses (MOOCs).Conclusions: Medical schools need to provide faculty support to overcome barriers that inhibit faculty use and sharing of e-learning resources. Our findings suggest future directions in terms of content areas that we should focus on creating and sharing resources in order to respond to current challenges in medical education.
Structure-Guided Engineering of Immunotherapies Targeting TRBC1 and TRBC2 in T Cell Malignancies
Authors: Ferrari Mathieu , Baldan Vania , Wawrzyniecka Patrycja , Bulek Anna , Kinna Alex , Ma Biao , Bugda Reyisa , Akbar Zulaikha , Srivast Saket , Ghongane Priyankha , Gannon Isaac , Robson Matthew , Sillibourne James , Jha Ram , Lim Wen Chean , Hopkins Jade , Welin Martin , Surade Sachin , Dyson Michael , McCafferty John , Cordoba Shaun , Thomas Simon , Logan Derek , Sewell Andy , Maciocia Paul , Onuoha Shimobi , Pule Martin
Published: March 2022

Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells has limited the efficacy of immunotherapeutic approaches. The T cell receptor expresses one of two highly homologous chains [T cell receptor β-chain constant (TRBC) domains 1 and 2] in a mutually exclusive manner, making it a promising target. We previously described an antibody with unique TRBC1 specificity (Jovi-1). Here we demonstrate specificity redirection by rational design using structure-guided computational biology to generate a TRBC2-specific antibody (KFN). This permitted the generation of paired reagents (chimeric antigen receptor-T cell) specific for TRBC1 and TRBC2, with preclinical evidence to support their efficacy in T cell malignancies.
Development of a short-form Chinese Health Literacy Scale For Low Salt Consumption (CHLSalt-22) and its validation among hypertensive patients
Authors: Zhang Yanli , Zhang Hanjing , Li Song , Li Yuetong , Hu Cunjie , Li Hongyu
Published: March 2022

Background:With the accelerated pace of people's life and the changed dietary patterns, the number of chronic diseases is increasing and occurring at a younger age in today's society. The speedily rising patients with hypertension led it to becoming one of the main risk factors for chronic diseases. People should focus on health literacy related to salt consumption and reach a better quality of life. At present, there is a lack of local assessment tools for low salt consumption in mainland China. Objective:To develop a short-form version of Chinese Health Literacy Scale For Low Salt Consumption instrument for using in mainland China. Methods:A cross-sectional design was conducted in a sample of 1472 people in Liaoxi, China. Participants completed a sociodemographic questionnaire, the Chinese version of the CHLSalt-22, the measuring change in restriction of salt (sodium) in diet in hypertensives (MCRSDH-SUST), the Brief Illness Perception Questionnaire (BIPQ) and the Benefit-Finding Scales (BFS) to test the hypothesis. Exploratory factor analysis and confirmatory factor analyses were performed to examine the underlying factor structure of the CHLSalt-22. One month later, 37 patients who participated in the first test were recruited to evaluate the test–retest reliability. Results:The CHLSalt-22 demonstrated adequate internal consistency, good test–retest reliability and satisfactory construct validity, convergent validity and discriminant validity. The CHLSalt-22 count scores were correlated with age, sex, body mass index (BMI), education level, income, occupation, the Measuring Change in Restriction of Salt (sodium) in Diet in Hypertensives (MCRSDH-SUST), the Brief Illness Perception Questionnaire (BIPQ), and the Benefit-Finding Scales (BFS). Conclusion:The results indicate that the version of the Chinese Health Literacy Scale For Low Salt Consumption (CHLSalt-22) has good reliability and validity, and that it can be considered a tool to assess health literacy related to salt consumption in health screenings.
Engineering Branching Morphogenesis Using Cell Communication
Authors: Marquette Christophe , Devillard Chloe
Published: March 2022

Branching morphogenesis, a specialized part of morphogenesis, leads to the formation of microstructures (tubes, canals, and glands), source of the active organ functions. The dynamic mechanisms involved are appearance/disappearance of biomolecules morphogens gradients. In the context of angiogenesis, growth factors allow the initiation, regulation, and remodeling of blood vessels. In the particular case of micro-vascularization, it seems essential to reproduce and study the interaction of endothelial cells with their environment but also with other cellular components, including fibroblasts. To bring understanding here, we developed an angiogenesis 3D bioprinted model based on a proliferative bioink populated with fibroblasts and HUVECs. We demonstrated that we were able to recapitulate branching angiogenesis, producing organized microvascularization in 7 days only. We clearly demonstrated that a bidirectional communication was at stake between the two cell types, evidenced only when both types were culture in a 3D environment. Proteomic results consolidated the understanding of this phenomenon, with 11 angiogenic proteins identified in the co-culture supernatant. They were identified as inducers of vasculogenesis and angiogenesis. Through matrix composition and cell organization study, we were able to demonstrate that tissue remodeling, extracellular matrix production (type I collagen), phenotype modification (pericytes) were taking place in our branching morphogenesis model.
Utilization of A Meteorological Satellite for Planetary Science as A Space Telescope: The Lunar Mid-Infrared Spectrum as Seen by Himawari-8
Authors: Nishiyama Gaku , Namiki Noriyuki , Sugita Seiji , Uno Shinsuke
Published: March 2022

The Japanese meteorological satellite Himawari-8 has been capturing not only the earth’s atmosphere, but also stars, planets, and the moon in its field of view and enables us to take their spectroscopy with 16 bands from visible to mid-infrared wavelengths. Especially for the lunar case, nine infrared bands equipped in the Advanced Himawari Imager (AHI) onboard Himawari-8 are unique in spaceborne observations and potentially useful for lunar science. Besides, the infrared bands of AHI cover similar wavelengths with those of other interplanetary instruments, thus are useful for their calibrations. However, the infrared AHI data have not been investigated in planetary science. To confirm the utility of AHI for planetary science, we develop the procedure to retrieve the lunar infrared spectrum and compare it with thermal conduction simulations. Our analysis shows that the lunar brightness temperature curves can be obtained in the morning, evening, and night sides at all nine bands. Particularly at 8.5 μm, they show a good agreement with the previous observation by the Diviner radiometer onboard NASA's Lunar Reconnaissance Orbiter. As pointed out previously, the brightness temperatures differ between bands, indicating the temperature mixing within a pixel. In the morning and evening, our simulation suggests that surface roughness as steep as those measured at Apollo landing sites significantly contributes to the observed brightness temperature differences. On the other hand, the nightside brightness temperatures are greatly affected by rocks that have higher thermal inertia than regolith. The rock abundances are estimated as 0.18 –0.48 and 5.6 –10.4 % at the equator and within Tycho crater, respectively. Our estimations from the AHI data are consistent with one from Diviner. These results support that AHI potentially serves as a space telescope for future lunar and planetary sciences, for example, to constrain water content on the lunar surface.
The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression
Authors: Feng Ninghan , Yao Bing , Zhu Sha , Wei Xiyi , Chen Ming-Kun , Feng Yangkun , Li Zhimin , Xu Xinyu , Zhang Yuwei , Wang Yang , Zhou Jingwan , Tang Ningyuan , Ji Chengjian , Jiang Peng , Zhao Shan-Chao , Qin Chao
Published: March 2022

Background: Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and its mechanism remains poorly understood. Therefore, it is urgent to discover potential novel diagnostic biomarkers and therapeutic targets that can potentially facilitate the development of efficient anticancer strategies.Methods: A series of functional in vitro and in vivo experiments were conducted to evaluate the biological behaviors of PCa cells. RNA pulldown, Western blot, luciferase reporter, immunohistochemistry and chromatin immunoprecipitation assays were applied to dissect the detailed underlying mechanisms. High-throughput sequencing was performed to screen for differentially expressed circRNAs in PCa and adjacent normal tissues.Results: Upregulation of protein arginine methyltransferase 5 (PRMT5) is associated with poor progression-free survival and the activation of multiple signaling pathways in PCa. PRMT5 inhibits the transcription of CAMK2N1 by depositing the repressive histone marks H4R3me2s and H3R8me2s on the proximal promoter region of CAMK2N1, and results in malignant progression of PCa both in vitro and in vivo. Moreover, the expression of circSPON2, a candidate circRNA in PCa tissues identified by RNA-seq, was found to be associated with poor clinical outcomes in PCa patients. Further results showed that circSPON2 induced PCa cell proliferation and migration, and that the circSPON2-induced effects were counteracted by miR-331-3p. Particularly, circSPON2 acted as a competitive endogenous RNA (ceRNA) of miR-331-3p to attenuate the repressive effects of miR-331-3p on its downstream target PRMT5. Conclusions: Our findings showed that the epigenetic regulator PRMT5 aggravates PCa progression by inhibiting the transcription of CAMK2N1 and is modulated by the circSPON2/miR-331-3p axis, which may serve as a potential therapeutic target for patients with aggressive PCa.