bluuebunny/crossref_metadata_2025 huggingface dataset:
Nomadic reindeer herding of the Kanin Peninsula and its transformations (the first third of the 20th century — first quarter of the 21st century)
Authors: Kiselev S.B.
Published: June 2022

The territory of the Kanin Peninsula is a part of Nenets Autonomous District (the north of European Russia), and it borders on the south with the Mezen River basin. The Kanin Tundra occupies almost the entire area of the peninsula. The Kanin Peninsula is the most western region of traditional inhabitance of the Nenets and Izhma Komi ethnic groups. Historically, the nomadic economy of local reindeer herders was based on combination of reindeer husbandry, hunting and fishing. In this paper, different types of nomadic reindeer herding in the region in the first third of the 20th century and transformations currently occurring in the traditional economy are analyzed. The main research sources are represented by the materials of the Circumpolar Census of 1926/27 and materials of the author’s field studies. In the paper, principal components of nomadic reindeer herding in the region were studied, such as herd size and composition, migrations routes etc. Moreover, the factors determining specifics of the economic structure of the Nenets and Izhma Komi groups are analyzed, namely, the nature of interactions between the nomadic and sedentary populations of the region and the degree of orientation toward the “market” of no-madic economies. Characteristics of three basic types of the nomadic economy (hunting-and-fishing, mixed, and large herding) are given. The economic focus of households was determining the content of all elements of the traditional lifestyle. In the early 1930s, collectivization began in the region, and the nomadic reindeer husbandry started developing within collective and state farms; there existed nomadic reindeer herding. This circumstance greatly affected the no-madic economy of the region. In the early 1990s, collective and state farms were transformed into agricultural coopera-tives. Comparing the nomadic economy of the two selected periods, it is concluded that the role of the reindeer hus-bandry in the occupational structure of the Nenets and Izhma Komi groups is currently increasing due to concentration of the industry within cooperatives. At the same time, the role of other occupations (hunting and fishing) is decreasing along with the loss of the natural foundations of the nomadic economy.
The people of the Arctic in the space of Russia: interdisciplinary approaches to the translocal communities
Authors: Zamyatina N.Yu. , Liarskaya E.V.
Published: June 2022

Thе paper is based on the results of the “Arctic connections: people and infrastructures” project (2018–2021) which was aimed at interdisciplinary study of modern population of the Arctic zone of the Russian Federation. The paper is focused on the study of social support networks and their spatial distribution. We combine socio-anthropological (qualitative) and economic-geographical (quantitative) methods of research and analysis; the field data obtained as the result of in-depth interviews and observation of the participants were corroborated by rigor-ous quantitative analysis of available demographic data. For the anthropological analysis we use the prism of translocality and transnationalism, which enable an understanding of the structure of lives of people who do not reside in only one place but are connected by many ties and relationships to a whole range of localities. The fami-ly life of the northerners is often distributed between several localities, scattered across the whole country, and sometimes beyond its borders. The location of these ‘bases’ depends primarily on the configuration of each fam-ily’s social networks. We call this ‘a distributed way of life’. The quantitative analysis was carried out using the methodology of calculating the Migration Indices of Proportionality of (spatial) Structure (MIPS) of departures and arrivals of the migrants, proposed by O.L. Rybakovsky. The geographical scope of the study is the entire Arctic zone of the Russian Federation, as well as the regions most connected with the Arctic by migration ties (the southern part of the Tyumen region, Kurgan, Kaliningrad, Belgorod, Kirov Regions, etc.). The results of the study revealed close interregional migration ties between the groups of regions that are significantly spatially separated from each other: 1) between the majority of the regions of the Far North, on one hand, and Kaliningrad and Bel-gorod Regions on the other; 2) between Khanty-Mansi Autonomous Okrug and the Republics of Dagestan and Bashkortostan; 3) between Yamalo-Nenets Okrug and the Republic of Bashkortostan and the Omsk and Kurgan regions, as well as the south of the Tyumen Region; 4) between Nenets Autonomous Okrug and Kirov Region. The qualitative studies have shown how the migration flows in these areas increase due to established social ties, which in some cases are sustained already for several generations. In the paper, the importance of the influence of interregional social ties, both for the Arctic and for the country in general, is demonstrated. The authors demon-strate how these connections between the “northern” and “non-northern” regions, which are separated by about a 1000 km distance, lead to such close relations which are more characteristic of relationships between a popula-tion center and its nearest periphery. This ultra-distant social proximity is a vivid manifestation of the specifics of the Russian North and Arctic.
Pottery of the population of the Kulayka Culture (Surgut variant) in the settlement of Barsova Gora III/2: technology and traditions
Authors: Selin D.V. , Chemyakin Yu.P.
Published: June 2022

Barsova Gora is a unique complex of archaeological sites of the Neolithic — Late Middle Ages. The repre-sentative body of the collected sources requires systematic analysis, primarily, of the pottery collections. This paper presents the results of technical and technological analysis of 50 vessels of the Kulayka Culture (Surgut variant) from different dwellings of the settlement of Barsova Gora III/2. The study of the technological markers was carried out with the aid of binocular microscopy of the surfaces and fractures of the ceramics, followed by the comparison with an experimental collection of technological markers. It has been determined that ferruginous low-sand clays were used as the raw ductile material. The main artificial admixture is represented by broken stone, while chamotte and organic substance are found in the clay paste only alongside the broken stone. It has been found that the principal recipe of the clay paste is clay + broken stone (64 %). The second most common recipe of the clay paste is clay + broken stone + chamotte (28 %). It is possible that the raw materials for the grus were imported from areas with stone outcrops, and/or unknown sources of stone from Barsova Gora and the surroun-ding area were used. The bottom and hollow body of the vessels were formed from laterally overlapping bands. External and internal surface treatments vary, and include 29 different combinations. A comparison of the pottery technology of the ceramics from the settlement of Barsova Gora III/2 with the pottery from the fortress of Barsov Goro-dok III/6 showed their similarity. Differences appear in particular adaptive skills of the potters. These differences can be explained by active two-way contacts of the population of Barsova Gora III/2 with the representatives of other ar-chaeological cultures who lived in this territory, and by the started processes of mingling of the pottery technology.
Sistem Monitoring Kelembaban Tanah pada Tanaman Tebu (MONTABU) Berbasis IoT
Authors: Hilman Abdullah , Wijaya Dirga Putra , Saidi Banta , Budiyanto Almira , Adinandra Sisdarmanto
Published: June 2022

Sektor pertanian merupakan salah satu sektor terpenting bagi perekonomian di Indonesia. Guna memastikan hasil panen yang baik, berbagai indikator harus dijaga dengan baik salah satunya adalah kondisi tanah pertanian. Kelembaban tanah merupakan salah satu parameter penting yang perlu dipantau dan merupakan indikator yang paling mudah untuk menggambarkan kondisi tanah. Tanaman tebu merupakan salah satu dari berbagai jenis tanaman yang cukup sensitif terhadap kelembaban tanah. Tanaman tebu memerlukan tingkat kelembaban tanah yang berbeda-beda pada setiap fase penanaman. Oleh karena itu, sistem MONTABU (monitoring kelembaban tanah tanaman tebu) dibuat untuk membantu memonitoring kelembaban tanah tanaman tebu sehingga meningkatkan keberhasilan hasil panen. sistem MONTABU dirancang dengan berbasis IoT (Internet of Things), sehingga pemantauan dapat dilakukan tanpa terbatas ruang dan waktu. Selain itu, sistem MONTABU di rancang menggunakan sumber daya menggunakan photovoltaic dari cahaya matahari, sehingga sumber daya dapat diperbaharui terus menerus. Secara umum, kerja dari sistem MONTABU adalah sensor kelembaban tanah membaca pengukuran besar kelembaban dari tanah di perkebunan tebu kemudian diolah pada mikrokontroler lalu mengirimkan hasil pengukuran tersebut melalui SMS pengguna dan aplikasi android. Pengujian diuji dalam 7 hari di kebun tebu Maredan, Berbah, Sleman. Sistem akan mengukur kelembaban satu hari sekali pada pagi hari, dengan nilai hasil kelembaban rata-rata 70%. Perangkat prototipe ini dapat dipasang diluar ruangan dan dapat mengirim pesan secara real time. Hasil dari sistem MONTABU telah berhasil mengukur dan mengirimkan notifikasi kelembaban tanah dengan keberhasilan 100% melalui SMS dan dapat dipantau real time menggunakan IoT. Dampak masalah sosial dan lingkungan pada MONTABU cukup mempengaruhi performa sistem, karena terjadi pengrusakan oleh manusia dan hewan pengerat.
MOMIDRO: Sistem Monitoring Pembangkit Listrik Tenaga Mikrohidro Berbasis IoT pada Laboratorium Ketenagaan FTI UII
Authors: Firdaus Firdaus , Ramadhan Dio Trie , Ahmad Yanayir , Suryani Putri Indah
Published: June 2022

Saat ini terdapat modul Pembangkit Listrik Tenaga (PLT) Mikrohidro di Laboratorium Ketenagaan Fakultas Teknologi Industri (FTI) Universitas Islam Indonesia (UII). Pengguna harus melakukan pengukuran secara manual on-site ketika membutuhkan data performa energi dari PLT Mikrohidro, sehingga cukup merepotkan. Perlu dicari solusi supaya pencatatan data performa bisa dilakukan dengan mudah, maka diusulkan sistem monitoring performa energi listrik AC berbasis Internet of Thing (IoT) pada Pembangkit Listrik Tenaga (PLT) Mikrohidro (MOMIDRO). Dengan sistem ini, pengguna cukup mengakses akun melalui browser untuk memonitor data performa secara akurat dan real-time. MOMIDRO menyediakan data pembacaan tegangan, arus, daya aktif, dan energi. Pengujian sistem dilakukan dengan memanfaatkan beban dari RLC Load. Sistem dapat melakukan monitoring dengan baik secara real-time. Hasil pembacaan modul sensor PZEM-004T pada sisitem ini memiliki nilai error rata-rata pembaca tegangan, arus, daya, dan energi masing-masing sebesar 0,7%, 21,2%, 2,32% dan 28,7%. Persentase error nilai arus dan energi cukup besar dikarenakan nilai arus dan energi yang sangat kecil, namun jika dilihat nilai selisihnya maka hasil pembacaan sensor sangat mendekati nilai acuan.
Microbial Degradation of Pharmaceuticals
Authors: Kandhasamy Swathi , Balraj Sudha , Kanagaraj Suganya , Sundaravadivelu Sumathi
Published: June 2022

Pharmaceutically active compounds and organic pollutants are becoming a major environmental dispute possessing serious threat to the water bodies and terrestrial ecosystem. Microorganisms are capable of the self-purification process, and hence the microbial degradation is considered a lucrative method to counteract the therapeutic and recalcitrant pollutants. Pharmaceutical toxicants in aquatic system can be treated by conventional wastewater treatment, but slow sludge settling, presence of mixture of pharmaceuticals and recalcitrant compounds often pose a potential ecological risk. Some microbial strains are very effective in reducing the chemical oxygen demand (COD), biological oxygen demand (BOD), total dissolved solids (TDS), and turbidity in pharmaceutical industrial wastewater treatment. The natural microbial community has a significant role in the ecological processes of pharmaceutical and organic compounds, including non-steroidal anti-inflammatory drugs, analgesics, blood lipid regulators and other micropollutants. Specific bacterial isolates can act as biodegraders, and fungal treatment could offer protection to the ecosystem. These microorganisms use the pollutants as their sole carbon source and transform the contaminants by co-metabolic pathways. Natural attenuation by native microorganisms, biostimulation and bioaugmentation are the processes employed to degrade the target contaminant. Microorganisms may also be genetically engineered to improve the neutralization efficiency, which would assist in the mineralization of the pollutants. Thus, employing microorganisms to detoxify the pollutants probably enhances the sustainable potential biodegradability, improves water quality standards and ensures eco-friendly alternative bioremediation strategy.
A novel vegetarian food based on Balinese traditional foods: variety, processing, and nutrition
Authors: Trisdayanti Ni Putu Eka , Dalem AA. Gd. Putra KP. , Atmaja Made Purwa Dana
Published: June 2022

Changing diet preference to vegetarian is certainly not easy. Most people are very dependent on the delicious taste of meat, so it is very difficult to switch to plant-based foods. In addition, tourists visiting Bali, especially vegetarians, will find it difficult to enjoy Balinese specialties, which are predominantly made from meat. With these issues in mind, and to suit the demands of both local communities and tourists, some vegetarian vendors in Bali started to offer vegetarian versions of traditional Balinese foods. The sample of Balinese traditional plant-based foods was analysed for their nutritional content. The data were analysed using the descriptive qualitative method. The Balinese traditional plant-based foods found in Ubud were Sate Lilit, Kuah Kare, Balinese soup, Sayur Urap, Betutu, Lawar, Tum, Dendeng/Ati, Sisit, Sate, and Urutan; which is made similar to Balinese food processing using Balinese spices (Base Genep) contains good nutrition.
Utilization of waste from trimming process for the development of pangasius fish nugget
Authors: Jenita Laudya , Fransisca  , Purnomo Wibisono Agus
Published: June 2022

Currently, the processing of pangasius fish is limited in most industries in Indonesia. This fish can be processed into nuggets, but the texture is a common issue determined by the composition of the meat and fat. Therefore, optimal composition is needed to produce the desired texture. The fat used was derived from the trimmings, waste of the Pangasius fillet factory. This study, then, aims to determine the effect of substitution of fillet with trimmings on chemical and sensory characteristics of fish nugget. Furthermore, it obtains the best formulation using 6 ratios of fillet and trimmings at 100:0, 60:40, 50:50, 40:60, 30:70, and 20:80. Proximate analysis of moisture, ash, carbohydrate, protein, and fat content was conducted, while acceptance testing was used in sensory analysis. The results showed that the substitution of trimmings only resulted in significant difference in fat content. This is due to the direct proportionality between the percentage of trimmings, and the fat content of nuggets. Meanwhile, the sensory analysis only resulted in significant differences in crispness, hardness and overall. In conclusion, nugget with 20:80 treatment was the best formulation because it has the highest preference value and can utilize waste optimally.
Macromolecular Distribution of a Mixed System on Dodol Ulame by Confocal Laser Staining Microscopy (CLSM)
Authors: Setiavani Gusti , Sugiyono  , Ahza Adil Basuki , Suyatma Nugraha Edhi , Wangdi Jamyang Tashi
Published: June 2022

The aim of this study was to learn more about the macromolecular distribution of the food matrix system in the traditional food Dodol Ulame in order to better understand the interactions between starch, fat and sugar. Microstructural stages included dye selection, staining/coloring, material mixing, and observation. The starch was stained with APTS and the fat with Nile red. The starch was stained using the double staining method with covalent labeling. The samples were analyzed with a Zeiss Inverted LSM 800 AXIO Observer equipped with an AXIO cam 503 color camera and an excitation wavelength of 665 nm and 543 nm. The results indicated that GR was polyhedral. Fat and sugar are evenly distributed in the matrix system. Some of the fat interacts with the starch granules to form a coating that prevents the starch from interacting with the sugar and inhibits the imbibition of water into the starch granules at 50 °C and 70°C. Amylose escapes from the granules and reacts with the sugar solution at a higher temperature of 90 °C, while the free fat acts as a lubricant between the particles. This shows how flour, fat and sugar interact to affect the manufacturing process and the final properties of dodol ulame.
Effect of chlorophyll in alginate-based edible film in inhibiting spoilage of fish snacks
Authors: Dewi Eko Nurcahya , Tassakka Asmi Citra Malina A.R. , Yuwono Mochammad , Suyono Eko Agus , Purnamayati Lukita , Alam Jamaluddin Fitrah
Published: June 2022

Edible films are environmentally biodegradable materials used for food packaging. The edible green alga Caulerpa racemosa has antimicrobial properties; however, its chlorophyll-based bioactive compounds can be damaged when heated so it is prepared in microcapsules. Our research evaluated the effect of Caulerpa microcapsules on an alginate-based edible film on film properties and food spoilage. The microcapsules were used at concentrations of 0%, 0.5%, 1%, and 1.5%. The edible film was measured for film properties, total phenolic content (TPC), antioxidant activity (DPPH), functional group (FTIR) and microstructure (SEM). Food spoilage was evaluated on a popular fish-based product (fish bubble snacks). Bacterial strains of Escherichia coli and Staphylococcus aureus were used to evaluate antimicrobial effectiveness of the edible films. The addition of Caulerpa microcapsules had no significant negative effect on physical properties of the alginate-based film, while the smoother and more homogenous surface should enhance the barrier properties of the film. The slow and evenly distributed release of active compounds from the microcapsules increased resistance to Rhizopus sp. and significantly reduced the proliferation of E. coli but not S. aureus on coated fish snacks. Caulerpa racemosa can be used to enhance the effectiveness of alginate-based films in delaying spoilage and could extend product shelf-life
Corpo Editorial
Authors: Mendes Ricardo Evandro
Published: June 2022

Descrição do Corpo Editorial
Technology Focus: Completions (April 2022)
Authors: Lehr Doug
Published: June 2022

Data science continues to provide solutions for unconventional-well challenges. But innovative combinations of proven technologies also are delivering improved success in artificial lift wells. The articles I have selected for this feature provide details on these achievements. But can the learnings from one type of completion improve success in other types of completions?

The shale gas revolution is over 20 years old. The pace of innovation has been rapid, and many technologies and methods have been developed that reduce completion time and maximize access to the reservoir with one well. Unconventional-well innovation, therefore, has led to constant improvements in efficiency and reliability. There is no doubt this will continue, but can unconventional learnings be applied in conventional completions?

Electrical submersible pumps (ESPs) and intelligent-completion technologies are complementary, but each have very different service lives. For example, intelligent-completion hardware may have a 20-year service life, while ESPs may have a 2-year service life. So how can they be integrated in a way that ensures long-term reliability in the intelligent completion while accommodating periodic ESP workovers? Reimagining completion architecture is one way that a Middle East operator has achieved this goal.

Can large logging-while-drilling and measuring-while-drilling data sets be used to optimize completion of the well? One paper explains how perforation cluster design in Marcellus wells can be optimized by analyzing these data sets using a convolutional neural network model. The key to optimization involves mechanical specific energy. Is the lesson here to drill with the completion in mind or to complete with drilling in mind?

Will drilling engineers and completion engineers answer the last question differently, or will they agree on a different paradigm for the next well or project? It has been said that you will get the same result by repeating what you have done. But if you want to have a better result, you must change what you are doing. Is it time for a paradigm shift?

Recommended additional reading at OnePetro: www.onepetro.org.

SPE 199712 - Evaluating Limited-Entry Perforating and Diverter-Completion Techniques With Ultrasonic Perforation Imaging and Fiber Optic DTS Warmbacks by Chase Murphree, SM Energy, et al.

SPE 207862 - Modeling a Novel Approach To Delay the Water Breakthrough in Gas Cap Wells Using Smart Completions: Case Study Onshore Abu Dhabi Field by Aditya Ojha, ADNOC, et al.

SPE 201268 - DTS Flow Profiling for a Horizontal Multistage Fractured Well in Tight Gas Reservoirs by Improved Model Considering an Openhole Packer Completion Scenario by Weibo Sui, China University of Petroleum, et al.
Speed-adaptive PI Collection and PP Adjustment in Indoor VLC Network
Authors: Gong Guiyu , Gan Chaoqin , Zhu Yifan , Hu Qiuyue
Published: June 2022

In this paper, a novel adjustment scheme of the position-predicted period (PP: position-predicted period) in indoor VLC network is proposed. The scheme is adaptive to the movement speed. It contains two key parts: speed-adaptive PI collection (PI: position information) and speed-adaptive PP adjustment. By user’s mobile characteristics, speed-adaptive PI collection is realized to lift prediction accuracy. By distribution characteristics of received power, speed-adaptive PP adjustment is achieved to avoid unnecessary predictions. The AP selection based on position prediction can effectively improve the user’s transmission rate. By the AP selection based on position prediction and the PP adjustment scheme adaptive to movement speed, the user’s transmission quality under different movement speeds can be improved. Finally, by simulation, the effectiveness of this scheme is demonstrated.
The influence of 10-year Nuss bar placement on bar removal: a case report
Authors: gu haihua , xu guanxin , liu tianshu , Zhang Sai
Published: June 2022

Background: Nuss bar is commonly used for minimally invasive correction of pectus excavatum and is usually removed within 2-3 years.Here,we report a case of 10-year bar placement after Nuss procedure, accompanied by unique complications of thoracic malformation that have not been described before. The asymmetric pectus carinatum caused by bar displacement and significant rib periosteal hyperplasia is described for the first time.Case presentation: A 23-year-old man was admitted to our hospital due to the main complaint of obvious chest discomfort when lifting weights.He had undergone the Nuss procedure for pectus excavatum. Due to loss to follow-up, two bars were placed for 10 years.Chest asymmetry and distant heart sounds were found during physical examinations.The chest CT scan demonstrated the right end of the lower bar originally fixed outside the ribs had shifted into the thoracic cavity,and the left costal cartilage was obviously protruding. Additionally,the displaced bars were tightly attached to the pericardium, resulting in abnormalities of the anterior mediastinum. These secondary thoracic deformities made it extremely prone to massive hemorrhage or multiple rib fractures when sliding out the bars. However,serious consequences were avoided due to reasonable adjustments to the usual bar removal procedures.The patient was discharged on the sixth postoperative day. He had a follow-up one month after surgery and had no chest discomfort.The postoperative rib CT showed there were no rib fractures.Conclusions: This case demonstrates a specific type of bar displacement caused by prolonged placement of the bars, and highlights the importance of rigorous follow-up in patients after Nuss procedure.
Construction of a prognostic nomogram for transarterial chemoembolization combined with 125I seed implantation for hepatocellular carcinoma with portal vein tumor thrombus: a multicenter retrospective study
Authors: Zhao Xiao-Hui , Zhao Lei , Zhao Yan , Li Hai-Liang , Li Zhen , Cao Guang-Shao , Li Hong-Le , Xu Shi-Jun , Hu Hong-Tao
Published: June 2022

Background: To investigate the efficacy of transhepatic arterial chemoembolization (TACE) combined with 125I seed implantation in patients with first-branch portal vein tumor thrombus (PVTT) hepatocellular carcinoma (HCC), establish a prognostic nomogram to determine the prognosis for individual patients.Methods: We retrospectively collected 97 cases of TACE combined with 125I seed implantation in our hospital as the primary cohort. The main observation index of the results of the study was the median overall survival (mOS). Univariate analysis, optimal subset regression(OSR) and LASSO regression were used to screen the variables. The selected variables were included in the multivariate Cox survival regression model, and a prognostic nomogram was developed. The performance of the nomogram was assessed with respect to calibration, discrimination, and clinical usefulness. The internal and external verifications were evaluated.Results: The mOS of all patients was 12.5 months. The final determination was made using the Child-Pugh score, tumor burden, PVTT types and PLT level to establish a nomogram prediction model [C -index :0.771 (95% CI: 0.722-0.820)]. The model demonstrated good discrimination and calibration. Application of the nomogram to the external verification data still yielded good discrimination [C-index: 0.744], and good calibration. The decision curve analysis demonstrated that the clinical validity of the model is clinically useful.Conclusion: TACE combined with 125I seed implantation indicated better long-term outcomes in patients with HCC combined with type II PVTT. This nomogram can be used to predict the prognostic survival time of such patients and help doctors make decisions in clinical practice.
Design and feasibility of an implementation strategy to address Chagas guidelines engagement at the primary healthcare level in Argentina: a pilot study
Authors: Klein Karen , Roberti Javier , Rouvier Mariel , Belizan Maria , Cafferata Maria Luisa , Berrueta Amanda Mabel , Alonso Juan Pedro
Published: June 2022

Background: Chagas is a public health problem, especially in Latin America, exacerbated by migratory movements and increasing urbanization. Argentina has the highest number of cases in the region, with 1,500,000 infected people, with mother-to-child as the primary mode of transmission. Vertical transmission has been significantly reduced by treating women of childbearing age; several guidelines in the region recommend treatment as a primary prevention strategy for the child and a secondary prevention strategy for women and their families. Despite recommendations, women of childbearing age are not always treated, and children do not receive timely diagnosis and treatment. The objective of this research was to design an implementation strategy to improve using Chagas guidelines at the primary healthcare level and pilot it to assess its feasibility and the factors that influence its implementation in three primary health care centers, Argentina. Methods: We conducted a pilot feasibility study using the Consolidated Framework for Implementation Research. A qualitative process evaluation was conducted using semi-structured interviews with health care providers and observations in primary health care centers. Results: We developed a multifaceted implementation strategy including training, flowcharts and reminders, a register of suspected and confirmed Chagas cases, and the selection of a management facilitator. The pilot study took place between September 2019 and May 2020. The implementation level was heterogeneous and varied depending on the components, being the facilitating factors, the simplicity of the intervention, professionals’ willingness to expand the indication of serologic tests, and staff commitment to the adoption of intervention components. The main barriers were the change of authorities at the local level, some professionals´ reluctance to administer etiological treatment, staff shortages, lack of diagnostic supplies (linked to contextual factors), and the health emergency caused by the COVID-19 pandemic. Conclusions: Behavioral change strategies should be applied to improve implementation to address some of the main barriers, including support actions offered by opinion leaders, medical experts, and local health authorities. Rapid diagnostic tests should be readily available to maintain behavior changes. We suggest further refinement of the strategy and its implementation in more centers to assess outcomes prospectively with a hybrid implementation research design.
Transformation of a human placenta into a pre-vascularised breast implant.
Authors: Almelkar Shahdab , Walawalkar Sonal
Published: June 2022

Reconstructive surgery is the leading, vital yet critical, and brain-storming interdisciplinary field. Fabrication of large-sized, implantable, low-cost, bio-prosthesis like breast implants is a great challenge. Here, we propose combining the traditional method (decellularization by perfusion technique and cross-linking) and the contemporary method of co-culture. We used the human placenta for its advantages like abundant extracellular material, rich vascularity, and conservation of many growth and angiogenic factors. We confirmed acellularity by histology, the integrity of the vasculature by CT scan, and the presence of any pathogens using culture and sensitivity tests. We further re-plasticized sterile placental scaffold using ADSC (adipose-derived mesenchymal stem cells) and HUVECs (Human Umbilical Vein Endothelial Cells). Histology confirmed phenotypic plasticity and cellular migration on the microvasculature. The functionality of the re-cellularized graft was examined by studying cell viability and other biochemical assays. In this study, we successfully utilized the human placenta, a discarded, large-sized, temporary organ, for a pre-vascularized, low-cost, pathogen-free, low-immune, large-size breast construct. Our study projects the better possibilities of breast reconstruction to avoid post-operative complications like graft rejection, failure of angiogenesis, infection, capsular contractures, and muscular damage.
Usage of documents embedding for Person Name Disambiguation on the Web
Authors: LEBRUN Christophe , SCHUBERT Kieran , ZAFFORA Biagio , DOBROVOLSKI Dmitry , GAUDINAT Arnaud
Published: June 2022

This article introduces a new approach to improve person names’ disambiguation on Web based search using document embedding. This new approach drastically simplifies the pre-processing stage, while also outperforming state-of-the-art methods in a monolingual scenario. The addition of a summarization step, even if it comes with a drawback of increasing the computational cost, was able to significantly improve the performance of the whole pipeline. The methods were evaluated on the subset of English pages of the MC4WePS corpus with different metrics: BCubed precision, BCubed recall and F0.5-score. Therefore, the F0.5-score was improved by 5 percent compared to state-of-the-art on the English pages of the MC4WePS corpus. This allowed to take into account a realistic proportion of social media pages in the mix of search engine results.
Fatigue may be an early indicator of disease in Chinese patients with early rheumatoid arthritis
Authors: Gong Xun , TANG Yu , ASENSO James , WANG Yan-Run , SHI Wei , DENG Jia-Liang , RUI Jin-Bin , QIU Ying-Ying
Published: June 2022

Objective
To explore the incidence and clinical significance of fatigue in early RA (duration ≤ 1 year).
Methods
A total of 472 cases of early RA and 80 healthy controls matched by sex and age were recruited. The SF-36 was used to assess fatigue in early RA.
Results
①The incidence of fatigue in early RA was 63.00%, 44% of the patients with early RA had severe fatigue, and 32% had fatigue as the first symptom. ②There were significant differences in sex, education level, disability, sleep factors and depression between the fatigue and nonfatigue groups of early RA. The joint tenderness, tenderness index, HAQ, VAS and PGA in the early RA fatigue group were higher than those in the nonfatigue group. The level of IL-6 and DAS28 in the early RA fatigue group were significantly higher than those in the nonfatigue group, while the ESR and CRP, RF, and anti-CCP levels were not significantly different. ③Correlation analysis showed that fatigue severity was negatively correlated with education level in early RA and was positively correlated with the level of IL-6 and the DAS28. ④Logistic analysis showed that female sex, joint tenderness, VAS, HAQ and IL-6 levels were independent risk factors for early RA with fatigue.
Conclusion
These results suggest that severe fatigue occurs in early RA. Early RA with fatigue have more obvious joint pain, poorer quality of life and higher disease activity. Patients who need interventions for fatigue may be diagnosed with RA early in the course of the disease.
Bioreduction of Cr(VI) using a Propane-based Membrane BiofilmReactor
Authors: Liu Chunshuang , Zhang Luyao , Yu Haitong , Zhang Huijuan , Niu Hongzhe , Gai Jianing
Published: June 2022

The strong physiological toxicity of Cr(VI) makes it widely concerned in wastewater treatment. At present, the simplest and harmless method for treating Cr(VI) is known to be biologically reducing it to Cr(III), making it precipitate as Cr(OH)3(s), and then removing Cr(III) by solid separation technology. Studies have shown that Cr(VI) reduction bacteria can use CH4 and H2 as electron donors to reduce Cr(VI). Therefore, in this study, we used C3H8 as the only electron donor to investigate the potential of C3H8 matrix membrane bioreactor to treat Cr(VI) in wastewater. The experiment is divided into three stages, each stage runs stably for at least 30 days, for a total of 120 days. With the increase of the Cr(VI) load, the removal rate gradually decreased. In stage 3, when Cr(VI) concentration was 2.0 mg·L− 1, the removal rate was reduced from 90% in the first stage to 75%. According to X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis, it is known that Cr(III) is the main product during this process and it is adsorbed on the biofilm as Cr(OH)3 precipitate. During the experiment, the amount of EPS produced by microorganisms increased first and then decreased, and the amount of polysaccharides (PS) was always more than protein (PN). By analyzing the microbial community structure after inoculating sludge and adding Cr(VI), Nocardia and Rhodococcus dominate the biofilm samples. Chromate reductase, cytochrome c, nitrate reductase and other functional genes related to chromate reductase increased gradually with the experiment.
LPLUNC1 reduces glycolysis in nasopharyngeal carcinoma cells through the PHB1-p53/c- Myc axis
Authors: Oyang Linda , Ouyang Lei , Yang Lixia , Lin Jinguan , Xia Longzheng , Tan Shiming , Wu Nayiyuan , Han Yaqian , Yang Yiqing , Li Jian , Chen Xiaohui , Tang Yanyan , Su Min , Luo Xia , Li Jinyun , Xiong Wei , Zeng Zhaoyang , Liao Qianjin , Zhou Yujuan
Published: June 2022

Cancer cells usually prefer glycolysis to support their proliferation. Our previous studies have shown that the long palate, lung, and nasal epithelial cell clone 1 (LPLUNC1) can up-regulate prohibitin 1 (PHB1) expression to inhibit the proliferation of nasopharyngeal carcinoma (NPC) cells. Given that PHB1 is an important regulator of cell energy metabolism, we explored whether and how LPLUNC1 regulated glucose glycolysis in NPC cells. LPLUNC1 or PHB1 over-expression decreased glycolysis and increased oxidative phosphorylation (OXPHOS)-related protein expression in NPC cells, accompanied by enhancing PHB1 and 14-3-3σ expression and promoting phosphorylated PHB1 nuclear translocation. Co-immunoprecipitation indicated that 14-3-3σ directly interacted with phosphorylated PHB1. PHB1 Y259A mutant over-expression abrogated the decreasing glycolysis and increasing OXPHOS-related protein expression induced by LPLUNC1 over-expression in NPC cells. LPLUNC1 over-expression also increased p53, but decreased c-Myc expression in NPC cells, which were crucial for the decrease in glycolysis and increase in OXPHOS-related protein expression induced by LPLUNC1 over-expression. Finally, we found that treatment with all-trans retinoic acid (ATRA) reduced the viability and clonogenicity of NPC cells, decreased glycolysis and increased OXPHOS-related protein xpression by enhancing LPLUNC1 expression in NPC cells. Therefore, the LPLUNC1-PHB1-p53/c-Myc axis decreased glycolysis in NPC cells and ATRA up-regulated LPLUNC1 expression, a promising drug for intervention of NPC.
Enhanced Cr(VI) reduction and removal by Fe/Mn oxides biochar composites under acidic simulated wastewater
Authors: Chen Zhenshan , Liu Tao , Dong Jiefu , Chen Guoliang , Li Zhixian , Zhou Jianlin , chen zhang
Published: June 2022

Chromium (Cr(VI)) has attracted extensive attention because of its toxicity, which can cause severe damage to the ecosystem and human. In this paper, adsorbed Fe/Mn ions Bacillus cereus ZNT-03, lotus seeds, and graphene oxide were co-cultured as raw materials. Fe/Mn oxides biochar composite (FMBC) was prepared to treat Cr(VI) by one-step pyrolysis. FMBC has high-density micropores, and the average pore size is about 0.82 nm. Given the content of Fe (3.07 mg g− 1), Mn (2.56 mg g− 1), and N (3.04%) in the FMBC, Fe(II), Mn(II), and N-containing functional groups could be served as electron donors to reduce Cr(VI). The removal of Cr(VI) is monolayer chemisorption and pH-dependent. The maximum adsorption capacity of FMBC was 21.25 mg g− 1. Cr(VI) is reduced and adsorbed on FMBC by physical adsorption, reduction, complexation, electrostatic attraction, and co-precipitation. The contribution ratio of reduction mechanism to Cr(VI) is 72.25%. The packed column and regeneration experiments indicated that FMBC had high adsorption performance and excellent adsorption stability even after soaking in acidic simulated wastewater after 180 days (pH 1.5). These results indicate that FMBC can provide rapid reduction and efficient adsorption for Cr(VI), making it possible to apply in water treatment.
Dental health of patients with X-linked hypophosphatemia – a controlled study
Authors: Larsson Amila , Regnstrand Tobias , Skott Pia , Mäkitie Outimaija , Björnsdottir Sigridur , Legert Karin Garming
Published: June 2022

Objective: The present study compared the dental health of patients with X-linked hypophosphatemia (XLH) with healthy age- and gender-matched controls to increase our knowledge of the impact of XLH on oral health. Materials and methods: Twenty-two adult patients with XLH in the Stockholm region of Sweden were referred to the Department of Orofacial Medicine at Karolinska Institutet for an extended clinical and radiological examination. Pre-existing radiologic examinations of 44 healthy age- and gender-matched controls were retrieved from the Department of Oral Radiology, at Karolinska Institutet. Results: The 22 patients with XLH (15 females, median age 38 years, range 20–71; 7 males, median age 49 years, range 24–67) had a significantly higher number of root-filled teeth compared to healthy controls (p = .001). In the XLH group, females had significantly better oral health than males, especially concerning endodontic and cariological status (p’s = .01 and .02, respectively). Periodontal status differed non-significantly between the XLH and control groups. Conclusion: Patients with XLH had a significantly lower oral health status compared to a healthy population especially concerning endodontic conditions. Male patients with XLH had a higher risk of poor oral health compared to female patients with XLH.
The Comprehensive Detection of miRNA and circRNA in the Regulation of Intramuscular and Subcutaneous Adipose Tissue of Laiwu pig
Authors: Feng Hui , Yousuf Salsabeel , Liu Tianyi , Zhang Xiuxiu , Huang Wanlong , Li Ai , Xie Lingli , Miao Xiangyang
Published: June 2022

circRNAs, as miRNA sponges, participate in many important biological processes. However, it remains unclear whether circRNAs can regulate lipid metabolism. he purpose of this study is to explore the ceRNA regulatory network that affects the difference between intramuscular fat (IMF) and subcutaneous fat (SCF) deposition, and to screen key circRNAs and their regulatory genes. In this experiment, we identified 265 differentially expressed circRNAs, of which 187 up-regulated circRNA and 78 down-regulated circRNA in IMF. Subsequently, we annotated the function of DEcircRNA's host genes, and found that DEcircRNA's host genes were mainly enriched in GO terms(Including cellular response to fatty acids, lysophosphatidic acid acyltransferase activity, R-SMAD binding, etc) and signaling pathways(Fatty acid biosynthesis, Citrate cycle, TGF- β Signal pathway) related to adipogenesis, differentiation and lipid metabolism. By constructing a circRNA-miRNA network, we screened out DEcircRNA that can competitively bind to more miRNAs as key circRNAs (circRNA_06424 and circRNA_08840), and built a ceRNA network with key circRNA as the center. Through the functional annotation of target genes and protein network analysis, circrna_ 06424 affects the expression of PPARD, MMP9, uba7 and other target genes by competitively binding to miRNAs such as ssc-mir-339-5p, ssc-mir-744 and ssc-mir-328, and participates in PPAR signaling pathway, Wnt signaling pathway, unsaturated fatty acid and other signaling pathways, resulting in the difference of fat deposition between IMF and SCF. The results of this study provide a theoretical basis for further studying the differences of lipid metabolism in different adipose tissues, and provide potential therapeutic targets for ectopic fat deposition and lipid metabolism diseases.
Analytical Fractured reservoir characterization by using geological and petrophysical log
Authors: Movahed Zohreh , Aghajari Farzaneh
Published: June 2022

Background and Objectives: Due to structural complexities in some wells, higher than the expected thickness of Asmari formation is found. Fracture intensity and deep-rooted fractures broadly increase the risk of unpredictable water production. The well test analysis is not sufficient in describing fracture properties. Unfortunately, the core condition is poor in the fractured zones and cannot be used to provide reliable information. So, the objectives of this study are developing an accurate structural model for Asmari reservoir,fracture characterization in the borehole by interpreting image logs ,and comparing the log's image results with core data.Materials and Methods: Dip classification based on a geological log has the value of providing a direct demonstration of structural origin and detect Asmari fault and fracture systems and its impact on production and answer structural issue. So, in this study, the borehole imaging tools were interpreted to find solutions for fracture systems and fracture attributes.Result: Interpreting accurate structural dip determined structural problem, thus bringing the precise location of the well within the Asmari reservoir. Fracture properties (open or closed), occurrence, orientation, spacing, and porosity were interpreted using Image log . The high density of fractures seen on FMS image logs in the study well has been confirmed by inspection of the cores and the distinction between major and minor fracture types from the FMS image logs has been established following core review.Conclusion.As a result, this exercise has been confirmed to be very valuable, not only for indicating the value of the log data, but it has also emphasised some significant limitations of the core data. The amount of information extracted from the FMS image logs goes beyond that achieved from the core. This exercise has validated why image logs are the main source of fracture information in the oil fields of Iran.
Slope stability analysis considering the strength anisotropy of c-φ soil
Authors: He Yi , Li Zhi , Wang Wenfa , Yuan Ran , Zhao Xiaoyan , Nikitas Nikolaos
Published: June 2022

In traditional slope stability analyses, soil is usually approximated as isotropic. However, naturally cohesive soil deposits are inherently anisotropic, primarily due to the directional arrangement of soil particles during their deposition process. In this paper, a generalized anisotropic constitutive model for c-φ soil is introduced to evaluate the influence of varying shear strength on slope stability. In this model, the initial strength anisotropy is defined by the variety of friction angles to the direction of principle stress. This model is utilized by two approaches to estimate the slope stability. Firstly, the upper bound limit analysis solution for slope stability is developed, and the factor of safety of the slopes are studied. Secondly, this model is coupled with the finite element method to get insight of the influence of anisotropy on slope stability. One typic case of slope is studied by numerical analyses. It is found that the slope stability is largely overestimated when the strength anisotropy is ignored, and the overestimation, in terms of safety factors, can reach up to 32.9%. The complex interrelations between degree of anisotropy and evolution of the ensuing safety factor is revealed by a series of parametric study in terms of different degrees of anisotropy.
Light-driven progesterone production by InP-(M. neoaurum) biohybrid system
Authors: Liu Kun , Wang Feng-Qing , Liu Ke , Zhao Yunqiu , Gao Bei , Tao Xinyi , Wei Dongzhi
Published: June 2022

Progesterone is one of the classical hormone drugs used in medicine for maintaining pregnancy. However, its manufacturing process, coupled with organic reagents and poisonous catalysts, results in irreversible environmental pollution. Recent advances in synthetic biology have demonstrated the microbial biosynthesis of natural products, especially difficult-to-synthesize compounds, synthetic from building blocks is a promising strategy. Herein, overcoming the heterologous cytochrome P450 enzyme interdependency in Mycolicibacterium neoaurum successfully constructed the CYP11A1 running module to realize the metabolic conversion from waste phytosterols to progesterone. Subsequently, progesterone yield was improved through strategies involving electron transfer and NADPH regeneration. The CYP11A1 and ADR were connected by a flexible linker as a chimera to enhance electron transfer. Strain MNR-08 showed positive activity, with 45 mg/L progesterone, leading to a 3.95-fold improvement over strain MNR-04. Significantly, a novel inorganic-biological hybrid system was assembled by combining MNR-08 and InP nanoparticles to regenerate NADPH, which was increased 84-fold from the initial progesterone titers to 235 ± 50 mg/L. Altogether, this work highlights the green and sustainable potential for synthetic progesterone from sterols in M. neoaurum.