bluuebunny/crossref_metadata_2025 huggingface dataset:
BRCA Tumor Analysis as Molecular Screening for Germline Testing
Authors: Domínguez Mercedes Durán , Morales Alejandro González , Fernández-Aránguiz Blanca Ascensión Hernando , Burgos-Valladolid-Madrid Cooperative group: , Aras Enrique Lastra , González Gonzalo García , Herrero Guillermo Crespo , Gallego Iria Gallego , Morán Laura Ortega , Domínguez Mercedes Durán , Infante Sanz Mª del Mar , López Patricia Saiz
Published: June 2020

Background: In patients with advanced high-grade serous ovarian cancer (HGSOC) and prostate
adenocarcinoma, the identification of somatic/germline BRCA1/2 mutations allows new therapeutic
opportunities. To estimate the prevalence of somatic and germline BRCA1/2 mutations in non-mucinous
high grade ovarian/fallopian tube/peritoneal extraovarian cancer (NMHGOC) and prostate adenocarcinoma.
Methods: Prevalence was established by analyzing patients with NMHGOC or prostate adenocarcinoma,
with a BRCA1/2 study in the tumor between 2017 and 2018. Whether a germline study had been carried
out was subsequently reviewed.
Results: 10 patients out of 43 (23.3%) with NMHGOC had a BRCA1/2 mutation in the tumor. 9 patients
(20.9%) presented a BRCA1/2 mutation in the germline setting (2 without tumor result due to limited tissue
sample). 3 patients (6.9%) had only somatic mutations. 30% of the mutations in the tumor were, therefore,
somatic mutations. Of the 9 patients with prostate adenocarcinoma, 2 (22.2%) had a BRCA2 mutation in
the tumor. While 1 (11.1%) had the mutation in the germline setting, 1 patient (11.1%) had only somatic
mutations.
Conclusion: In our series, the prevalence of somatic and germline BRCA1/2 mutations in NMHGOC is
similar to that reported in the literature. Whereas somatic mutations are only present at the neoplastic tissue,
the rate of mutations in the tumor is higher than in the germline setting. A more effective diagnostic and
predictive strategy could be achieved with tumor BRCA analysis as the first attempt. Initial results in
prostate adenocarcinoma point to the same conclusion for this tumor.
Laparoscopic Treatment of De Garengeot´s Hernia with Appendicitis
Authors: Lima Favaro Murillo De , Marconi Iamarino Ana Paula , Da Silva Cíntia Magalhães , Ramos Da Silva Janaina Quagliareli , Ribeiro Marcelo , Lima Favaro Murillo De , Gabor Silvio
Published: June 2020

Introduction: The Garengeot’s hernia is a rare femoral hernia and its diagnosis should be suspected when
we identified a bulging in the right iliac fossa associated with anorexia and signs of inflammation. Their
treatment is still subject to divergences, and there is no common opinion about its treatment.
Presentation of Case: Female patient, LAT, 60 years old, had come to Grajau General Hospital (GGH) at
the Emergency Room (ER) presenting abdominal pain localized in the right iliac fossa. Computerized
tomography showed femoral hernia at right with mesenteric fat, cecal appendix and lymphonodes that
suggested regional inflammatory process. The patient was submitted to a laparoscopic surgery with closure
of the hernia ring without the placement of a mesh.
Conclusion: The laparoscopic approach can be used as less invasive method of treatment and it presents
better results.
Factors Associated with Occult Adverse Pathologic Features in Prostate Cancer Patients Eligible for Active Surveillance
Authors: Haddad Ahmed , Haddad Ahmed , Trivedi Jaimin , Ankem Murali , Rai Samarpit
Published: June 2020

Purpose: We examined factors associated with the presence of occult adverse pathologic features at
prostatectomy in patients otherwise eligible for active surveillance.
Materials and Methods: Using the National Cancer Database, we identified all low and favorableintermediate risk prostate cancer patients diagnosed from 2010-2016. The cohort was randomly divided into
test and validation groups. Logistic regression was used to identify factors associated with adverse
pathology at prostatectomy. Kaplan Meier analysis was used to determine overall survival difference in men
with or without adverse pathology.
Results: Among 168,505 active surveillance eligible patients, 83,153 underwent radical prostatectomy. In
men who received prostatectomy, the rate of occult adverse pathologic features defined as pT≥3b, Grade
Group ≥ 4 or pN1 was exceedingly low (2.3-6.1%). The rate of adverse pathology was 15.85-35.1% when
using a less restrictive definition (pT≥3a, Grade Group ≥ 3 or pN1). The number of positive biopsy cores
was independently associated with an increased risk of adverse pathology (OR= 1.11, p<0.01). The absolute
risk of adverse pathology remained low even at high positive core count. The AUC of the logistic model for
prediction of adverse pathology improved with the addition of a number of positive biopsy cores to the
NCCN criteria (0.610 to 0.649 in the test cohort and 0.638 in the validation cohort). 7-year overall survival
was 93%, with no difference between patients with or without adverse pathologic features.
Conclusion: We identified pre-surgical factors associated with occult adverse pathology in active
surveillance patients who underwent prostatectomy. This model may help select patients for additional risk
stratification with genomic assays or multiparametric MRI prior to treatment decisions.
Aggressive Behaviour of Merkel Cell Carcinoma in a Kidney Transplant Patient Receiving Tacrolimus Treatment – Is There an Alternative in Immune Checkpoint Inhibitor Treatment?
Authors: Gallucci Giuseppina , Bochicchio Anna Maria , Gallucci Giuseppina , Cagiano Luigi , Grieco Michele , Fabrizio Tommaso
Published: June 2020

Background: Merkel cell carcinoma (MCC) is a rare skin neoplasm first described by Toker in 1972. The
tumor usually presents in the sixth to seventh decade of life as a solitary reddish-brown to violaceous
subcutaneous nodule on the head, neck, or the extremities. It is seen at an earlier age only in
immunocompromised patients like transplant patients in immunosuppressive therapy. Thus, cancer has now
become the second cause of death among transplant patients. The tumor growth is rapid in MCC patients,
and for metastatic disease, no substantial benefit is obtained by chemotherapy. A new drug has recently
become available, an immune checkpoint inhibitor (CPI), avelumab, that is able to delay disease progression
significantly. However, there are no current guidelines for the use of immune checkpoint inhibitors in
transplant patients.
Case Presentation: We describe the case of a 55-year-old kidney transplant patient on immunosuppressive
therapy with tacrolimus with an early occurrence of a Merkel cell carcinoma whose aggressive behaviour
could not be hampered by Avelumab, due to fear of allograft rejection.
Conclusion: CPI therapy is potentially lifesaving in advanced MCC. Further studies are urgently needed to
test its benefit in this rapidly expanding field of post-transplant malignancies where there are only a few and
less effective therapeutic options.
Ultrasonic Activation of the Sonosensitizer Fimaporfin Enhances the Efficacy of Chemotherapy: An In Vitro Study on Rat Glioma Cells
Authors: Nguyen Le Jimmy , Høgset Anders , Hirschberg Henry , Nguyen Le Jimmy , Berg Kristian , Gederaas Odrun A , Madsen Steen J
Published: June 2020

Activation of sonosensitizers via focused ultrasound, i.e., sonodynamic therapy, has been proposed as an
alternative to light-activated photodynamic therapy for the treatment of a number of conditions from cancer
to bacterial infections. The use of focused ultrasound allows treatment to sites buried deep within tissues,
overcoming one of the main limitations of light-based modalities. Photochemical internalization is a
technique that utilizes the photochemical properties of photodynamic therapy for the release of trapped
endo-lysosomal macromolecules into the cell cytoplasm, greatly enhancing their efficacy. We have
examined ultrasonic activation of disulfonated tetraphenyl chlorin (fimaporfin) together with the anti-cancer
agent bleomycin, termed sonochemical internalization, as an alternative to light-activated photochemical
internalization. Our results indicate that, compared to drug or focused ultrasound treatment alone, focused
ultrasound activation of fimaporfin together with BLM significantly inhibits the viability of glioma
monolayers and the treated cells’ ability to form clonogenic colonies.
Primary Thyroid Lymphoma in an Adolescent with Hashimoto’s Thyroiditis and Congenital Deafness
Authors: Eelen Yeleni , Heerden Jaques van , Verlooy Joris , Norga Koen , Tousseyn Thomas , Eelen Yeleni
Published: June 2020

Background: Primary thyroid lymphoma is extremely rare in children and adolescents. The diagnosis of
thyroid malignancies is often made secondary to other thyroid pathologies including Hashimoto’s thyroiditis
(HT).
Case Presentation: This case describes a 14-year-old girl with a background of HT and congenital deafness
that presented with a rapidly enlarging multinodular thyroid mass. She underwent a total thyroidectomy and
a diffuse, large B-cell lymphoma was diagnosed on pathology.
Discussion: Primary thyroid disease is an extremely rare disease in childhood, usually presenting as a
rapidly enlarging goitre. The correlation between Hashimoto’s thyroiditis and primary thyroid lymphoma
is well-established in adults but has not been verified in the paediatric population. Our patient also has βthalassemia and Usher syndrome, however, no correlation between these and primary thyroid lymphoma
could be found in the literature.
Conclusion: It is important to include malignancy in the differential diagnosis of thyroid enlargement or
unexplained symptoms, especially in the presence of syndromes. Further research into the relation between
lymphomas and HT in the paediatric population is needed.
Malignant Ovarian Dysgerminoma Following Ovulation Induction in Patients with Polycystic Ovarian Syndrome: A Literature Review and Two Case Reports
Authors: Hemida Reda , Said Ahmed , Zalata Khaled , El-lakkany Naser , Hemida Reda
Published: June 2020

Background: The relation of ovarian induction drugs to development of ovarian cancer is still unclear.
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that has been reported as a risk factor
for ovarian cancer in some studies.
Case presentation: We report two cases with polycystic ovarian syndrome who developed a malignant
ovarian dysgerminoma following use of ovulation induction drugs. One of them was diagnosed during fifth
month of pregnancy by intracytoplasmic injection (ICSI). Both cases were treated with conservative
surgery.
Conclusion: We reported 2 cases of ovarian dysgerminoma in patients with PCOS following ovarian
stimulation. A large multicenter observational study is recommended to investigate a possible association.
A Preliminary Study of the Absorption and Metabolism of Temperate Propolis by Human Subjects
Authors: Watson Dave , Alotaibi Abdullah , Alqarni Abdulmalik , Alghamdi Adel , Watson Dave , Fearnley James , Rofaidi Mohammed Al
Published: June 2020

Temperate propolis is collected by bees from the sticky secretions produced by the buds of poplar species.
It is used to coat and seal the hive thus protecting against infections. Extensive research indicates that
propolis has strong anti-protozoal activity. There have been some large clinical trials testing propolis against
a variety of conditions but despite there is no information on whether or not the active components in
propolis are absorbed by humans. In order to answer this question, a small study was carried out in order to
determine whether or not propolis components could be detected in the urine of 5 human subjects taking a
small dose of propolis tincture. In two of the subjects, levels of several of the flavonoids present in the
propolis tincture many times above the baseline levels were detected following hydrolysis of the urine
samples with a glucuronidase/sulfatase. Analysis of urine samples prior to hydrolysis indicated the presence
of glucuronides and sulfates of the main flavonoids in propolis. Flavonoid absorption occurred to some
degree in all subjects, apparent lower levels of flavonoid absorption in 3 out of five subjects might indicate
genuine differences in level of absorption between subjects.
The ADeViD Study: Alzheimer’s Dementia and Vitamin D Study
Authors: Castagna Alberto , Castagna Alberto , Ruberto Carmen , Ruotolo Giovanni , Attisani Giuseppe , Greco Laura , Costa Raffaele , Cerra Rosa Paola
Published: June 2020

Introduction: Aging is associated with a large increase in the prevalence of hypovitaminosis D. 25-
Hydroxyvitamin D, 25(OH)D, is the best indicator for vitamin D status. Its possible role in the pathogenesis
of Alzheimer’s disease (AD), the leading cause of dementia in the elderly, is particularly important. The
aim of the present study was to examine the association between 25-hydroxyvitamin D (25(OH)D) and
cognitive functions in a group of Italian elderly patients affected with AD.
Methods: We studied the relationship between 25(OH)D and cognitive functions assessed by MMSE (Mini
Mental State Examination) in 150 consecutive elderly patients (F 76 %, age 78,66+ 6,05 years old) attending
our Geriatric ambulatory for cognitive disorders with diagnosis of AD.
Results: In our sample hypovitaminosis D was present in 100% of the screened patients; 111 patients (74%)
had 25(OH)D serum levels inferior to 20 ng/ml; 39 (26%) patients had serum levels included between 20
and 30 ng/ml. After adjustment for age, gender, systolic blood pressure, education, cardiovascular diseases
and antihypertensive treatment, a significant relationship was observed between 25(OH)D and cognitive
status. MMSE appeared significantly higher in subjects with 25(OH)D serum levels ≥ 20 ng/ml than in those
with 25(OH)D < 20 ng/ml (18,42+4,33 vs 12,22+4,44; p=0,000).
Conclusion: Our results showed a relationship between 25(OH)D and cognitive impairment in patients with
AD, suggesting that 25(OH)D could be involved in the onset of dementia.
Colonialization Impacts on the Inhabitants and Voices of Liberal Writers
Authors: Saeed Nadia , Shaikh Muhammad Ali , John Stephen
Published: June 2020

Colonialism is a policy in which a strong nation enters a weak territory and starts exploiting the inhabitants of that land for their economic interests. The colonizers dominate the colonized through violence to bring them into their subjection. Some liberal writers have written about colonialism and its impacts on the colonized slaves. Chinua Achebe has presented the realistic picture of Africa when it was colonized by the Britishers. His novel, "Things Fall Apart" presents the pre-colonial and colonial states of Africa that make it easy to understand how colonialization impacted the culture and lives of the natives. The paper justifies Franz Fanons point of view that the colonial world divides humans into the colonist and the colonized and this difference is created by colonists to assert their superiority
Performance of Agriculture Sector in Foreign Trade of Pakistan
Authors: Ali Gulzar , Mustafa Ghulam , Shah Said Zamin
Published: June 2020

The vigorous and dynamic expansion and technical progression of the agriculture productivity pave the way to considerable achievements in providing raw materials to the industrial sector and fulfilling domestic demand. The agriculture sector has an imperative role in poverty reduction, growth, increased employment opportunities and increasing foreign exchange reserves through exportable agricultural products. In short, agriculture is the backbone of economic stability and development in the country. This study is an attempt to investigate the performance of the agriculture sector and its impact on Pakistans foreign trade. The findings of the study revealed the affirmative and noteworthy role of the agriculture sector in the foreign trade of Pakistan during 1980-2017. The policymakers and government of Pakistan should encourage private and public investors for agriculture investment to enhance the production and agricultural exports.
Syllabification of English Words by Pashto Speakers
Authors: Shahabullah  , Rahman Ghani , Khan Arshad Ali
Published: June 2020

Syllabification of words plays a vital role in learning native like pronunciation. The present study tried to explore the syllabification of English words by Pashto speakers. The study aimed to put light on the problematic areas for Pashto speakers in terms of syllabification of English words. The data was collected from twenty undergraduate students and analyzed with reliable scientific tools. The analyzed data proved that English words having triphthongs were problematic for Pashto speakers. In addition to it, words having syllabic consonants were also problematic for Pashto speakers. Furthermore, words containing x in spelling also proved to be problematic for Pashto speakers. English words having the syllable structure CVC.VC were incorrectly syllabified CV.CVC. Pashto speakers faced problems in the identification of syllable boundaries in words where consonant clusters are used. The study recommends that Pashto speakers need proper training for learning correct syllabification of English words.
Genomic and molecular characterization of pituitary adenoma pathogenesis: review and translational opportunities
Authors: Elsarrag Mazin , Patel Parantap D. , Chatrath Ajay , Taylor Davis , Jane John A.
Published: June 2020

OBJECTIVE

Innovations in genomics, epigenomics, and transcriptomics now lay the groundwork for therapeutic interventions against neoplastic disease. In the past 30 years, the molecular pathogenesis of pituitary adenomas has been characterized. This enhanced understanding of the biology of pituitary tumors has potential to impact current treatment paradigms, and there exists significant translational potential for these results. In this review the authors summarize the results of genomics and molecular biology investigations into pituitary adenoma pathogenesis and behavior and discuss opportunities to translate basic science findings into clinical benefit.

METHODS

The authors searched the PubMed and MEDLINE databases by using combinations of the keywords “pituitary adenoma,” “genomics,” “pathogenesis,” and “epigenomics.” From the initial search, additional articles were individually evaluated and selected.

RESULTS

Pituitary adenoma growth is primarily driven by unrestrained cell cycle progression, deregulation of growth and proliferation pathways, and abnormal epigenetic regulation of gene expression. These pathways may be amenable to therapeutic intervention. A significant number of studies have attempted to establish links between gene mutations and tumor progression, but a thorough mechanistic understanding remains elusive.

CONCLUSIONS

Although not currently a prominent aspect in the clinical management of pituitary adenomas, genomics and epigenomic studies may become essential in refining patient care and developing novel pharmacological agents. Future basic science investigations should aim at elucidating mechanistic understandings unique to each pituitary adenoma subtype, which will facilitate rational drug design.
Optimizing pre-, intra-, and postoperative management of patients with sellar pathology undergoing transsphenoidal surgery
Authors: Cote David J. , Iuliano Sherry L. , Catalino Michael P. , Laws Edward R.
Published: June 2020

OBJECTIVE

Perioperative management of patients with sellar lesions is complex, requiring input from a multidisciplinary team of specialists for ongoing management of both endocrinological and neurosurgical issues. Here, the authors reviewed the experience of a single multidisciplinary center over 10 years to identify key postoperative practices that ensure positive outcomes for patients with sellar lesions who undergo transsphenoidal surgery.

METHODS

The authors performed a retrospective review of all transsphenoidal operations carried out by the senior author at a single center from April 2008 through November 2018. They included only adult patients and recorded perioperative management. They also reviewed the evolution of clinical practices for perioperative care at their institution to identify strategies for ensuring positive patient outcomes, and they reviewed the literature on select related topics.

RESULTS

In total, 1023 operations in 928 patients were reviewed. Of these, 712 operations were for pituitary adenomas (69.6%), and 122 were for Rathke cleft cysts (11.9%). The remainder included operations for craniopharyngiomas (3.6%), arachnoid cysts (1.7%), pituitary tumor apoplexy (1.0%), and other sellar pathologies (12.2%). Among the reviewed operations, the median hospital stay was 3 days (IQR 2–3). Patient management details during the pre-, intra-, and postoperative periods were identified, including both shared characteristics of all patients undergoing transsphenoidal surgery and unique characteristics that are specific to certain lesion types or patient populations.

CONCLUSIONS

Patients with sellar lesions who undergo transsphenoidal surgery require complex, multidisciplinary perioperative care to monitor for common adverse events and to improve outcomes, but there is a dearth of high-quality evidence guiding most perioperative practices. Here, the authors reviewed practices at their institution across more than 1000 transsphenoidal operations that may help ensure successful patient outcomes.
Assessing the surgical outcome of the “chopsticks” technique in endoscopic transsphenoidal adenoma surgery
Authors: Serra Carlo , Staartjes Victor E. , Maldaner Nicolai , Holzmann David , Soyka Michael B. , Gilone Marco , Schmid Christoph , Tschopp Oliver , Regli Luca
Published: June 2020

OBJECTIVE

The “chopsticks” technique is a 3-instrument, 2-hand mononostril technique that has been recently introduced in endoscopic neurosurgery. It allows a dynamic surgical view controlled by one surgeon only while keeping bimanual dissection. Being a mononostril approach, it requires manipulation of the mucosa of one nasal cavity only. The rationale of the technique is to reduce nasal morbidity without compromising surgical results and complication rates. There are, however, no data available on its results in endoscopic surgery (transsphenoidal surgery [TSS]) for pituitary adenoma.

METHODS

The authors performed a cohort analysis of prospectively collected data on 144 patients (156 operations) undergoing TSS using the chopsticks technique with 3T intraoperative MRI. All patients had at least 3 months of postoperative neurosurgical, endocrinological, and rhinological follow-up (Sino-Nasal Outcome Test–20 [SNOT-20] and Sniffin’ Sticks). The surgical technique is described, and the achieved gross-total resection (GTR) and extent of resection (EOR) together with patients’ clinical outcomes and complications are descriptively reported.

RESULTS

On 3-month postoperative MRI, GTR was achieved in 71.2% of patients with a mean EOR of 96.7%. GTR was the surgical goal in 122 of 156 cases and was achieved in 106 of 122 (86.9%), with a mean EOR of 98.7% (median 100%, range 49%–100%). There was no surgical mortality. At a median follow-up of 15 months (range 3–70 months), there was 1 permanent neurological deficit. As of the last available follow-up, 11.5% of patients had a new pituitary single-axis deficit, whereas 26.3% had improvement in endocrinological function. Three patients had new postoperative hyposmia. One patient had severe impairment of sinonasal function (SNOT-20 score > 40). The operation resulted in endocrine remission in 81.1% of patients with secreting adenomas.

CONCLUSIONS

This study shows that the chopsticks technique confers resection and morbidity results that compare favorably with literature reports of TSS. This technique permits a single surgeon to perform effective endoscopic bimanual dissection through a single nostril, reducing manipulation of healthy tissue and thereby possibly minimizing surgical morbidity.
Nursing Therapy in Hallucinations of Schizophrenia Patients A Literature Review
Authors: Sugiarto Angga , Suyanta Suyanta , Erawati Erna , Handayani Sri
Published: June 2020

Background: Hallucination is a problem that appears in schizophrenia as a positive symptom that must be addressed immediately so as not to disturb the health status. Nursing therapy is the main alternative to resolve hallucinatory problems in schizophrenic patients who are treated at the Mental Hospital.Methods: The method used is literature review with a library of articles or journals from 2010-2019 by searching through Google Scholar, Pro Quest, GALE, EBSCOhost, and Ovid Journal.Results: The results of the synthesis show that nursing therapy can overcome the problem of hallucinations in schizophrenic patients.Conclusion: CBT and group activity therapy as nursing therapy are effective for hallucinations of schizophrenia
The Effect of Prenatal Massage Towards Anxiety Level of Third Trimester Pregnant Women in The Work Area Of Cibeureum Public Health Center Tasikmalaya 2019
Authors: Ardianti Eva , Pertiwi Sinar , Rohmatin Etin
Published: June 2020

Background: During pregnancy, most women experience psychological and emotional changes, it often comes up in the third trimester. Anxiety itself will have a negative impact on pregnant women to delivery, such as the fetal nervous and hindering growth, weakens the uterine muscle contraction, and others. One way to overcome anxiety in pregnancy with non-farmokologi method is prenatal massage.Methods: The study design used was pre-experimental research design with one group pretest posttest. Sampling in this research using purposive sampling technique with a sample size of 30 people. Pretest and posttest data retrieval using a measuring instrument HARS Scale (Hamilton Rating Scale for Anxiety). The data were analyzed using univariate and bivariate using Spearman Correlation Test.Result: Obtained results correlation value 0.769, it shows that the correlation is very strong with 0,000 ρvalue (ρvalue 0.05).Conclusion: Thus prenatal massage was effective to reduced the anxiety level of third trimester pregnant women
1992: Escuchar a América Latina
Authors: Redacción Consejo de
Published: June 2020

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Ya comenzó el siglo XXI: el Norte contra el Sur
Authors: Gorostiaga Xabier
Published: June 2020

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Centroamérica en la encrucijada
Authors: Jerez César
Published: June 2020

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"La economía de mercado" (Recensión)
Authors: Barroso Campos Carmen
Published: June 2020

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"Problemas de legitimación en el Estado Social" (Recensión)
Authors: Porras Nadales Antonio J.
Published: June 2020

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Reseñas
Authors: Giner de Grado Carlos , Yuste Moyano Rafael , Trechera Herreros José Luis , Romero Rodríguez José Juan , Sequeiros San Román Leandro
Published: June 2020

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竖井(斜井)开挖施工中导井堵渣的预防和处理措施
Authors: 杨 晓辉 , 刘 旭刚
Published: June 2020

随着我国水利水电事业的飞速发展,对整体经济建设起到了良好的推动作用。水利水电工程在施工中也能够引进现代化技术,来解决施工环节的各类问题。然而在竖井与斜井的开挖环节,经常因为地质与人为因素造成堵井现象,不仅影响施工效率,而且还会构成安全隐患,基于此,文章针对竖井与斜井开挖施工中导井堵渣的预防与处理措施进行研究,根据问题制定针对性的优化对策。希望对相关从业人员提供一定的参考与借鉴。
浅析加快小型农田水利工程管理体制改革
Authors: 杨 利华
Published: June 2020

本文主要针对加快小型农田水利工程管理体制改革展开研究,首先阐述了小型农田水利工程管理体制的原则,其次提出了加快小型农田水利工程管理体制改革的重要性,并且提出小型农田水利工程管理体制改革存在的主要问题,最后提出了加快小型农田水利工程管理体制改革的建议。
水利泵站机电设备的安装与检修技术探讨
Authors: 王 伟 , 张 帅
Published: June 2020

水利泵站主要用于农田排灌、城市给排水以及跨流域调水等,在水资源的合理调度和管理中具有重要作用。随着泵站的建设在逐渐增多,人们对泵站的施工技术和安装技术也提出了更高的要求。文主要解释了机电设备的安装技术,分析了安装过程中存在的风险问题,然后提出了解决方案。希望达到提升国内水利泵站机电设施建设的质量、为推动其发展提供参考的目的。
水利水电工程项目施工质量管理的探析
Authors: 金 燕子 , 陈 华杰 , 张 思毅
Published: June 2020

水利水电工程建设目的主要是服务于人民,除害兴利,从而使自然界水资源得到合理分配。因此为了保证水利水电工程可靠运行,必须加强对其开展施工质量管理,基于此,本文阐述了水利水电工程项目中的施工质量管理内容,对水利水电工程项目施工质量管理的影响因素及其策略进行了探讨分析,旨在增强水利水电工程质量。
河长制工作存在问题及运行机制探析
Authors: 塔依尔 阿斯亚木 •
Published: June 2020

全面推行河长制能够在加强水污染治理、增强水的安全性方面发挥着非常积极的作用,并且也是我国有效改善水环境的关键。但是,因我国落实河长制的时间比较短,而且在这一方面也缺少丰富的经验,因此,在全面实施河长制的过程中存在着很多问题。面对这种现象,就需要加大对其中存在问题的研究力度,并且对河长制的未来出路加以明确,以此来有效指导河长制的真正落实,并且将其作用充分发挥出来。鉴于此,本文就河长制工作存在问题及运行机制展开探讨,以期为相关工作起到参考作用。
生态理念下的农田水利建设对策
Authors: 卡地尔 热依汗古丽 •
Published: June 2020

农田水利工程项目建设和生态环境需要统筹发展,这也是现代化水利事业可持续发展的基本需求。在环境要素方面的设计人员认为要充分根据该地区地形和水文、气候条件等方面的因素,重视三农中农村水利工程规划设计,逐步改善传统设计方式,根据生态哲学理念的要求,充分发挥出水利工程项目建设的社会效益、生态效益和经济效益。基于此,本文主要分析了生态理念下的农田水利建设对策。
新形势下自动化技术在机械设计制造中的应用浅析
Authors: 杨 帆
Published: June 2020

在新形势背景下,计算机技术更迭迅速,应用范围越发广泛,不仅使人们的生活方式、学习方式以及工作方式发生了翻天覆地的改变,并且促进了社会的长远发展。但在实际应用时,还存在不少问题,虚拟化应用以及信息化应用程度还不高,在一定程度上对机械制造行业的健康、稳定发展产生了诸多不良影响,阻碍了产业发展。本文主要就新形势下自动化技术在机械设计制造中的应用进行讨论分析,以供参考。
3S技术在水利工程地质勘测中的应用
Authors: 周 峰
Published: June 2020

水利工程作为一项基础性建设与中国国计民生有着直接的关系,在这其中有一项重要的环节就是地质勘测,对地质进行勘测时采用3s技术,勘测准确率提升的同时勘测效率也会有所提升,以此将水利工程信息化建设得以实现。因此,本文对水利工程地质勘查中3s技术的应用进行了阐述。
城市电网规划中常见问题及对策研究
Authors: 王 友江
Published: June 2020

随着我国社会的发展和不断进步,很多企业开始不断地进行扩张,大部分的人群涌入到城市当中。因此这也就导致了城市面积在不断扩大的过程,出现了电力供应不足的状况。在城市中供电问题不单单是因为电网本身存在一定的问题,还和城市的发展状况,和人们的需求有关,那么在城市电网规划的过程当中就需要更加深入地进行研究,这样才能够保证城市电网建设能够和城市的发展共同前行。因此本文将主要对城市电网规划中常见问题及对策研究展开相应论述。
智能电网中的电力设计关键技术
Authors: 陈 宏勤
Published: June 2020

伴随经济与科技的发展进步,智能技术开始在各个领域都有所应用,而且都取得了比较可观的成绩,在电力行业中自然也会利用到智能技术。在如今高速的双向通信网络中,智能电网的应用可以让整个电力系统的用电安全可靠,既能保障用电的需求,同时更符合我国生态可持续发展的理念。因此智能电网的建设以及关键技术的探索,已经成为目前电力行业十分重视的话题。本篇文章针对电力设计的主要技术环节进行了建设性的探讨。
农村电费回收的探析
Authors: 徐 鹏
Published: June 2020

随着我国社会生活水平,空调、电冰箱等电器普及到各家各户之中,为电力市场带来了极大的用户需求。电力作为人们日常生活和工作不可缺少的重要内容,为人们提供了极大的便利,但农村却因为种种原因而无法实现高效的电费回收,常常出现电费拖欠或拒缴的现象,这不仅阻碍了电力企业的正常工作,还对电力企业的经营产生了较大的影响。现就农村电费回收存在问题进行探讨,并提出了应对的措施。
水利工程建设与运行管理结合的问题及对策
Authors: 林 锋
Published: June 2020

水利工程是社会基础设施建设重要项目,新时期水利工程建设力度不断增强,投入了大量的人力、物力和财力,相应的也对水利工程建设和运行管理提出了更高的要求。水利工程可以实现水资源合理配置与利用,改善我国水资源分布不均的状况,所以为了保证水利工程充分发挥原有作用,应进一步加强水利工程建设与运行管理,加强各个环节的管理把控,打造高质量的水利工程项目。分析水利工程建设与运行管理结合,阐述具体现状和问题基础上,提出优化改进建议。
水利水电工程设计中地基处理技术研究
Authors: 张 伟
Published: June 2020

现阶段我国经济正处于飞速发展中,水利水电工程作为我国基础项目的主要部分之一,也得到了充分的发展和应用,尤其是在建筑行业地基处理中发挥着重要作用。但是在目前的应用中,地基处理技术还存在许多问题,也会影响整个工程质量,本文主要研究水利水电工程设计中地基处理技术的应用,从地基处理技术以及注意事项方面进行探讨,希望可以改善水利水电工程质量,满足日新月异的发展需求,为我国地基处理技术的成熟应用起到促进作用。
黄河水利工程项目施工管理及管理创新
Authors: 杨 军
Published: June 2020

社会在不断发展,科技也在进步,我国各行各业有了新的要求。黄河水利工程健康发展中离不开水利工程项目施工管理,想要保证水利工程健康稳步发展,必须落实水利工程项目施工管理,不断完善施工管理体系,加强施工过程监管,提高管理人员和施工人员的综合素质,促进我国水利事业朝着健康的方向前行,让黄河成为造福人民的幸福河。
水利工程水土保持生态修复技术的应用
Authors: 史 皓男
Published: June 2020

我国幅员辽阔,物资丰盈,但存在分部不均衡的现象,人均水资源占有率较低,尤其是随着社会经济的发展,工业、农业用水需求与日俱增,这种水资源供应的矛盾越来越严峻,水利工程项目的出现在很大程度解决了水资源分布不均衡的问题。然而从生态环境可持续发展视角来看,水利工程的建设对我国不少地区的土地资源、生态环境都造成了不利影响,亟需依托水土保持生态修复技术等来促进人类与自然的可持续发展。文章分析了水利工程建设存在的问题,剖析了水利工程水土保持生态修复技术应用的必要性,探讨了水利工程水土保持生态修复技术应用的要点,并尝试提出了水利工程水土保持生态修复常用的技术,以供参考。
防渗技术在水利工程施工中的应用
Authors: 杨 晶
Published: June 2020

在水利工程施工过程中,渗漏问题是非常常见的质量问题之一。防渗技术作为水利工程建设的关键内容,亦是水利工程建设中的质量控制要点,直接影响到水利工程的质量和安全。基于此,文章就防渗技术在水利工程施工中的应用进行分析。
基础灌浆施工技术在水利工程中的应用
Authors: 刘 丽
Published: June 2020

基础灌浆施工技术作为工程建设的重要技术方式,可以显著提升工程建设质量,在开展建设施工中,需要施工人员凭借自身经验,以认真严谨的态度对待各个施工环节,提升工程的可靠性和稳定性,为其后期正常运行奠定基础。本文以基础灌浆施工技术在水利工程中的应用为主线,进行了简要的分析和描述。
生态理念在水利水电设计过程中的应用
Authors: 马 双平
Published: June 2020

随着社会经济和科学技术的发展,水利水电工程对人们日常工作生活的影响也越来越大。在水利水电过程中应用生态理念,不仅能够有效的提升资源的吕勇率,还能促使环境得到可持续发展。本文主要研究生态理念在水利水电工程中的应用。
浅谈农田水利渠道工程的衬砌施工技术及其施工工艺
Authors: 张 阳
Published: June 2020

水利是保障农业稳定发展的不可或缺的重要环节,早期农田灌溉都是通过传统的土渠输水,将灌溉水从事先挖好的渠道中输送灌溉水,但是很多水都会由渠道底部、边坡土壤孔隙渗漏,在一定程度上浪费了很多水,现代的灌溉技术则很好的弥补了这个缺陷,通过对灌溉渠道进行防渗漏改造。可以降低农业用水在运输过程中因土壤空隙导致渗流。本文旨在通过对农田水利渠道工程衬砌施工工法的描述进而对衬砌施工技术及其施工工艺进行了探讨分析。
丘陵地区微喷管工程管网布置
Authors: 张 伟妮 , 周 坪
Published: June 2020

微喷管作为高效节水灌溉形式之一,广泛应用于瓜果蔬菜及经济作物的灌溉上,可以节水、节能,并且具有很强的实用性等特点。本文主要论述微喷灌工程的规划、布置形式,管径的选择。为丘陵地区微喷管工程提供了经验。
水利水电工程施工安全管理与安全控制
Authors: 陈 合文
Published: June 2020

水利水电工程作为我国重要的民生工程,其安全质量情况将会直接影响到水利水电工程的应用效果。为此,本文将对水利水电工程施工安全管理与安全控制措施进行分析探讨,希望对水利水电工程发展有所帮助。
Acil Serviste Yapılan Kan Transfüzyonları Acil Servis İşleyişini Etkiliyor mu?
Authors: YÜKSEL Melih , KAYA Halil , ERAYBAR Suna , AYGÜN Hüseyin , BULUT Mehtap
Published: June 2020

Bu çalışmanın amacı acil serviste yapılan kan ve kan ürünleri transfüzyonlarının acil servis işleyişini etkileyip etkilemediğini araştırmaktır. 01.08.2019 ile 31.12.2019 tarihleri arasında Sağlık Bilimleri Üniversitesi Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi Acil Servisi’nde kan ve kan ürünü transfüzyonu yapılan hastalar çalışmaya dahil edildi. Çalışmaya alınan hastaların yaş, cinsiyet, yapılan transfüzyon türü ve sayısı, kan grubu, kan bekleme süresi, transfüzyon işlem süresi ve acil servisteki toplam kalış süresi değişkenleri kaydedildi. Toplam 227 hasta çalışmaya dahil edildi. Hastaların %54,6 ‘sı erkek olup ortalama yaş 63,86±17,81, ortalama hemoglobin (Hg) düzeyi 7,12±2,42 g/dL, ortalama kan bekleme süresi 6,44±3,02 saat, ortalama transfüzyon işlem süresi 3,54±3,45 saat, ortalama toplam acil serviste kalış süresi 10,13 ±4,00 saat olarak saptandı. Hastaların %74,0’ ünde anemi tanısı mevcut idi. Oneway Anova testi ile yapılan analizde acil serviste toplam kalış süresi ile hasta tanıları arasında anlamlı fark olduğu görüldü (F=4,235; p=0.001). Post hoc tukey testi ile farkın koagülasyon bozuklukları ile anemi (p=0.001) ve koagülasyon bozuklukları ile gastrointestinal sistem kanamalarından (p=0.013) kaynaklandığı saptandı. Acil endikasyonu olmayan kan ve kan ürünleri transfüzyonlarının acil servislerde yapılması acil servis yoğunluğuna ve hastaların bekleme sürelerinin uzamasına neden olmaktadır. Dolayısıyla bu işlemlerin acil servislerde yapılması acil servis işleyişini olumsuz yönde etkilemektedir.
Potencial de geração de Energia Elétrica a partir de sistemas de energia heliotérmica no Estado de Minas Gerais
Authors: Assis Matheus Miranda de , Cunha Marcelo José Pereira da
Published: June 2020

Diante do crescente consumo de energia elétrica vivenciado atualmente pela sociedade, há uma demanda cada vez maior na diversificação da matriz energética utilizando-se fontes renováveis. Ante este cenário, o presente trabalho analisa e avalia, com auxílio de análise espacial em Sistema de Informação Geográfica (SIG) utilizando os aplicativos Quantum Gis e ArcGis, os locais mais propensos à instalação de usinas heliotérmicas no estado de Minas Gerais. Foi feita uma revisão bibliográfica dos modelos de sistemas heliotérmicos, apontando o modelo de torre central como o mais vantajoso e eficiente em relação aos demais. O cruzamento de dados de irradiação direta normal disponibilizados pelo Solar and Wind Energy Resource Assessment (SWERA), base cartográfica do estado de Minas Gerais, base cartográfica de hidrografia e linhas de transmissão de energia elétrica, modelo digital de elevação elaborado a partir de dos dados do Shuttle Radar Topograpy Mission (SRTM) disponibilizadas pela United States Geological Survey (USGS) e, por fim, o quantitativo e espacialização de indústrias instaladas por município indicou duas regiões em Uberlândia/MG, como locais mais propensos à instalação de uma usina heliotérmica no estado.
BOARD-BASED LEARNING EXPERIENCE: A PRACTICAL APPROACH TOWARDS THE IMPROVEMENT OF STUDENTS’ INFORMATION LITERACY INTEREST AND ACADEMIC RESULT
Authors: Nurfaidah Anisa
Published: June 2020

Teaching information literacy has always been a challenging issue to tackle. Classical teaching and learning activities require students to sit, to read, to understand and to be able to answer questions to meet the minimum accomplishment criteria. To undergo joyful learning, this board-based learning experience has enabled the teacher to manifest varied teaching strategies despite the limited resources and also to facilitate students to develop their reading, communication, and social skills. The findings of this study indicate that this experience has represented positive impacts toward the improvement of students’ information literacy interest and academic results. Not only relatively livelier learning experience, it has stimulated students to use mind map strategy to locate keywords and to link them with details in an informational text, resulting in the progress of the individual score progress by average which reached 21.67 points. Special notes should be addressed to the teachers or other practitioners that we should always give attention to students to find ways to connect main ideas, supporting ideas and blend them into the context. As the conclusion, the teacher should be able to enhance their teaching skill by integrating any teaching strategies.
THE ROLE OF INTERNAL CONSTRAINTS AND FANTASY ELEMENT IN CREATIVE LANGUAGE TASKS FOR FOREIGN LANGUAGE LEARNERS
Authors: Araminta Lavinia D. W.
Published: June 2020

For the past few years, language teaching, especially for foreign learners, has become more and more creative. Creativity has been deemed paramount in the history of language use by human beings, including day-to-day language play and literary works. It is also suggested that creative language tasks are helpful for learners when it comes to writing. This small-scale study involving two Indonesian university students in Auckland was conducted to find out how adult learners, at any rate, take advantage of imagination in language learning. It examines the role of internal constraints and fantasy element in helping adult learners create meanings in doing creative language tasks. The results show that these two components in creative language tasks could help adult learners play with language. By combining prior knowledge and existing linguistic resources, the participants came up with new meanings from previously known concepts which did not seem to relate to each other. Specifically, input and outcome constraints are useful, while external constraints should be left out. Fantasy element is also beneficial as it requires an act of imagining. For recommendation, to stimulate students to experiment with language, teachers need to design creative tasks which have appealing topics and require them to collaborate.
Sudden death from diseases of the circulatory system of employees of enterprises of the Republic of Bashkortostan
Authors: Karimova Lilia K. , Gimaeva Z. F. , Astrelina T. N. , Muldasheva N. A. , Bakirov A. B. , Akhmadullina G. Kh.
Published: June 2020

Introduction. Over the past decade, in Russia and abroad, there has been a clear trend towards an increase in cases of sudden death in the workplace from the disease of the circulatory system. Material and methods. During the study, there were studied the databases of the State Labor Inspectorate in the Republic of Bashkortostan in 2014-2018, including accident investigation reports, information on a special assessment of working conditions, medical examinations, forensic medical examinations and other materials. Results. Diseases of the circulatory system (DSC) were the main cause of sudden death in the workplace in more than 90% of cases. The maximum number of cases of sudden due to DSC was recorded in the age group of 56-60 years. The overwhelming majority of the deceased cases were represented by working occupations - 82.8%, drivers of transport were in 13.7% of cases. The vast majority of deaths occurred in the morning (from 6 to 12) and daytime (from 12 to 18) hours. The working conditions of deceased DCS workers in most cases (59.8%) corresponded to the permissible class (class 2); under harmful conditions (subclass 3.1 - 3.3) 24.9% cases worked. Most often, some form of acute coronary heart disease (CHD) was mentioned as the immediate cause of death (64.0%). Among acute forms of coronary heart disease in medical documents in more than 50% of cases the code I 24.8 “Other forms of acute coronary heart disease” was established. “Acute myocardial infarction” was verified in 11.1% of cases and was the main cause of death in men. In the group “Cerebrovascular Diseases”, “Intracerebral hemorrhage” was most often diagnosed. Conclusion. The obtained results substantiate the need to develop measures to prevent sudden death in the workplace, aimed primarily at preventing the development, progression and early diagnosis of DSC.
Hygienic assessment of learning environment conditions (by the example of higher educational institutions of the city of Ufa)
Authors: Gorbatkova Elena Ju.
Published: June 2020

Introduction. The important factors affecting health and performance of young people are the conditions of education, in particular, a comfortable microclimate in the classrooms of higher educational institutions. Materials and methods. In view of the urgency of this problem, an analysis was made of the microclimate parameters of educational organizations of different profiles (Ufa city, the Republic of Bashkortostan). 294 classrooms were studied in 22 buildings of 4 leading universities in Ufa. A total of 3,822 measurements were taken to determine the parameters of the microclimate. The analysis of ionizing radiation in the aerial environment of classrooms. There was performed determination of radon and its affiliated products content. In order to assess the conditions and lifestyle of students of 4 higher educational institutions of the city of Ufa, we conducted an anonymous survey of 1,820 students of I and IV years of education. Results. The average temperature in the classrooms of all universities studied was 23.9±0.09 C. The average relative humidity in all classrooms was 34.2 ± 0.42%. Analysis of ionizing radiation (radon and its daughter products decay) in the aerial environment of the classrooms and sports halls located in the basement determined that the average annual equivalent equilibrium volumetric activity of the radon daughter products (EROA ± Δ222Rn) ranged from 28 ± 14 to 69 ± 34.5 meter, which meets the requirements established by SanPiN. Conclusion. The hygienic assessment of the microclimate parameters of educational institutions of various profile revealed a number of deviations from the regulated norms. The results indicate the need to control the parameters of the microclimate, both from the administration of universities, and from the professors. According to the results of the study, recommendations were prepared for the management of higher educational institutions in Ufa.
Investigation of Load Bearing Capacities of Grouted Rock Bolts with New Auxetic Head Designs
Authors: Komurlu Eren , Durmus Demir Aysegul , Celik Atila Gurhan
Published: June 2020

Within this study, new bolt heads were designed to be able to expand in drill holes as the load applied on the bolt shank increases. The heads of newly designed rock bolts include a conic part and split rings encircling them. To determine load bearing capacities of new rock bolts with varying angles of the conic parts and expansion properties, a series of deformation controlled pull-out tests were carried out by using bolt samples grouted in rock blocks. In addition to the experimental studies, numerical modelling analyses were performed to better understand the support properties of newly designed rock bolts. Because of a negative Poisson’s ratio effect supplied by the head part expansion with the tension of the shank, new bolt heads are suggested to be defined as auxetic. According to the results of this study, the new head designs significantly improve the load bearing and energy absorption capacities of grouted rock bolts.
Lithofacies from the 1963-1967 Surtsey eruption in SUSTAIN drill cores SE-2a, SE-2b and SE-03
Authors: McPhie Jocelyn , White James D.L. , Gorny Carolyn , Jackson Marie D. , Gudmundsson Magnús Tumi , Couper Samantha
Published: June 2020

Surtsey was drilled in 2017 in the context of the Surtsey Underwater volcanic System for Thermophiles,
Alteration processes and INnovative Concretes (SUSTAIN) project. Vertical drill holes, SE-02a and SE02b (drilled to 191.64 m), and angled drill SE-03 (drilled to 354.05 m), intersected armoured lapilli tuff and
lapilli tuff generated mainly by explosive eruptions at Surtur from November 1963 to January 1964. The
top ~20 m of lapilli tuff was erupted from Surtungur. Intervals of coherent basalt in SE-02b (15.7 to 17 m
and <15 cm at the end) and in SE-03 (<1 m at ~60 m and ~238 m, and 10 m near the base) are probably
intrusions that may have fed the small lavas erupted at Surtur ~2.5 years later. Although collared only a few
m from the 1979 drill hole, neither SE-02a nor SE-02b intersected the 13-m-thick interval of basalt found
in the 1979 drill hole. The 2017 drill cores are entirely lithified and variably altered, reflecting the effects of
hydrothermal alteration and cement deposition on the originally fresh, unconsolidated ash and lapilli. Drill
hole SE-03 was drilled on an azimuth of 264o
and at 55o
from horizontal, obliquely crossing the crater- and
conduit-fill of Surtur. Although the exact trajectory of SE-03 is unknown (the drill hole was not surveyed),
the drill hole ended at a vertical depth of ~100 m below the pre-eruption sea floor, however, sedimentary
facies known to underlie the sea floor nearby were not intersected. Surtur eruptions therefore excavated the
pre-eruption sea floor to a depth of several tens of m.
Petrograpic and material observations of basaltic lapilli tuff, 1979 and 2017 Surtsey drill cores, Iceland
Authors: Jackson Marie D.
Published: June 2020

Petrographic studies of thin sections from the 1979 and 2017 Surtsey drill cores provide new insights
into microstructural features in basaltic lapilli tuff sampled from the principal structural and hydrothermal
zones of the volcano. These describe narrow rims of fine ash on altered glass pyroclasts in thin sections of
the 2017 cores, characteristics of granular and microtubular structures in the original thin sections of the
1979 core, and glass alteration in diverse environments. The narrow ash rims follow the outlines of glass
pyroclasts in the subaerial tuff cone and in submarine and sub-seafloor deposits; they suggest complex
eruptive and depositional processes. The tubular microstructures resemble endolithic microborings in older
oceanic basalt; they suggest possible microbial activity. Tubule lengths indicate rapid growth rates, up to
30 µm in ~15 years. Comparisons of glass alteration in thin sections prepared immediately after drilling in
1979 and 2017 indicate differential time-lapse alteration processes in the structural and hydrothermal zones
of the volcano. In contrast, thin sections of the 1979 core prepared after 38 years in the repository reveal
labile glass alteration during archival storage. The oven-dry density of the sub-seafloor lapilli tuff decreases
in 2017 samples with high porosity and water absorption and increases in 2017 samples with a compact
ash matrix and lower water absorption. The petrographic descriptions and material measurements provide
a foundational reference for further investigations of explosive eruption and deposition of basaltic tephra
at Surtsey and the subsequent alteration of these deposits in the volcanic environment and, potentially, the
curatorial environment.
KNOWLEDGE OF THE LAW THROUGH A COMPREHENSIVE APPROACH USING APHORISMS
Authors: Захарцев Сергей , Сальников Виктор
Published: June 2020

The authors pay attention to the fact that every person understands the law in different ways, but at the same time unilaterally: they see one single positive or negative side of the law (truth, justice, cruelty, violence, truth, deceit, etc.). To know the law competently the authors propose a comprehensive approach, which aroused considerable interest among Russian and foreign scientists.
THE LAW OF INTERNATIONAL SECURITY: MODERN DEVELOPMENT CONDITIONS AND TRENDS
Authors: Филиппов Олег , Харисова Зарина
Published: June 2020

The article analyzes the concept and the system of international security law in connection with the expansion of the subject of legal regulation of the industry. A study of the legal basis formaking an international security system is being conducted. Challenges and threats to international security have been identified. The directions of development of cooperation between States in achieving the goals of the international security system are proposed.