bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduced expression level of protein phosphatase, PPM1E, serves to maintain insulin secretion in type 2 diabetes
Authors: Gheibi Sevda , Cataldo Luis Rodrigo , Hamilton Alexander , Huang Mi , Kalamajski Sebastian , Fex Malin , Mulder Hindrik
Published: January 2023

Reversible phosphorylation is an important regulatory mechanism. Regulation of protein phosphorylation in β-cells has been extensively investigated, but less is known about protein dephosphorylation. To understand the role of protein dephosphorylation in β-cells and type 2 diabetes (T2D), we first examined mRNA expression of type 2C family (PP2C) of protein phosphatases in islets from T2D donors. Phosphatase expression overall was changed in T2D, and that of PPM1E was most markedly downregulated. PPM1E expression correlated inversely with HbA1c. Silencing of PPM1E increased glucose-stimulated insulin secretion (GSIS) in INS-1 832/13 cells and/or islets from T2D patients while PPM1E overexpression decreased GSIS. Increased GSIS following PPM1E silencing was associated with decreased oxidative stress, elevated cytosolic Ca2+ levels and ATP/ADP ratio, increased hyperpolarization of the inner mitochondrial membrane and phosphorylation of CaMKII, AMPK and acetyl-coA carboxylase. Silencing of PPM1E, however, did not change insulin content. Increased GSIS, cell viability, and activation of AMPK upon metformin treatment in β-cells were observed upon PPM1E silencing. Thus, protein dephosphorylation via PPM1E abrogates GSIS. Consequently, reduced PPM1E expression in T2D may be a compensatory response of β-cells to uphold insulin secretion under metabolic duress. Targeting PPM1E in β-cells may thus represent a novel therapeutic strategy for treatment of T2D.
Análise das Percepções de Professores de Matemática em Formação Inicial e Continuada sobre a Aprendizagem Significativa e Crítica
Authors: Dos Reis Simone Regina , Santarosa Maria Cecília Pereira , Mathias Carmen Vieira
Published: January 2023

OO presente trabalho é um recorte de uma pesquisa mais ampla, que busca identificar as percepções prévias de professores(as) de matemática em formação inicial e continuada sobre o tema formação de professores(as) em uma perspectiva significativa e crítica. Por meio de um estudo de caso, adotando como referencial metodológico a análise de conteúdo de Bardin, essas percepções são analisadas sob a ótica da aprendizagem significativa e crítica, argumentando sobre as implicações dos resultados para a prática do ensino. Os dados analisados foram coletados ao longo do desenvolvimento de uma oficina sobre a formação de professores(as), com destaque para a participação de acadêmicos(as) de uma licenciatura em matemática, participantes do Programa Residência Pedagógica na condição de residentes, atuando colaborativamente com os(as) professores(as) da escola básica, na condição de preceptores(as) do mesmo programa. Dentre as percepções prévias identificadas na pesquisa, pode-se concluir que é preciso ampliar ainda as ações de formação de professores(as), para que se fomente a troca de experiências e a reflexão crítica sobre a própria prática dos(as) profissionais envolvidos(as) na formação continuada proposta. Os resultados também indicam que é possível observar que os(as) participantes ainda precisam reconhecer-se como profissionais em ações de ensino e de aprendizagem.
(re)constituição da identidade profissional de futuros professores de matemática no contexto da residência pedagógica
Authors: Gouveia de Sousa Ana Cláudia , Bezerra de Melo Carlos Ian , Santos Pontello Luiza , Da Silva Neta Maria de Lourdes
Published: January 2023

Este artigo discute a relação entre o Programa de Residência Pedagógica (PRP) e a constituição da identidade profissional docente (IPD), com o objetivo de identificar mobilizações nas IPD dos(as) residentes vivenciadas no contexto de um núcleo de matemática de uma IES pública federal. O percurso metodológico, de abordagem qualitativa, recorreu à técnica da coleta documental nos relatórios finais de um grupo de oito residentes, a partir das técnicas da análise de conteúdo. A pesquisa revelou que as mobilizações identitárias foram (re)constituídas considerando a relação entre os aprendizados da docência e a IPD, enfatizando as ambientações nas escolas, o apoio das preceptoras, a importância do planejamento e dos recursos e ferramentas digitais. Destacou também as reflexões enquanto aspecto formativo e constitutivo da IPD, como característica do núcleo, e o PRP como elemento identitário e espaço multi formativo da IPD, ilustrado pela interação entre residentes e professoras experientes.
Residência pedagógica matemática, inclusão e ensino remoto: desdobramentos para a formação inicial e continuada e para a identidade profissional docente
Authors: Bichara Guimarães Amália , Pinto Gisela Maria da Fonseca
Published: January 2023

NNeste artigo apresentamos a residência pedagógica do Núcleo de Matemática da Universidade Federal Rural do Rio de Janeiro, atendendo ao objetivo de analisar algumas vivências e desdobramentos para a formação docente inicial e continuada da participação nas duas edições deste programa. Para responder à questão: “A residência pedagógica contribui para a constituição da identidade profissional docente e para formação de seus atores?”, adotamos a metodologia das narrativas dos residentes sobre essa experiência, que se focam nos destaques voltados para a educação matemática inclusiva, no edital do ano de 2018, e para a questão do ensino remoto, no edital de 2020. A condução das análises pela preceptora e pela docente orientadora revelam o impacto considerável para a constituição e consolidação da identidade docente de todos(as) os(as envolvidos(as), que entendem que este programa deve integrar permanentemente os cursos de licenciatura.
Construindo novas compreensões sobre o ensino de matemática com o programa residência pedagógica
Authors: Queiroz de Oliveira Larissa , Borges de Oliveira Daniel , de Souza Pereira Grilo Jaqueline
Published: January 2023

O texto apresenta os principais resultados alcançados por um estudo que teve como objetivo analisar como os ambientes de aprendizagem mobilizados por um professor ao ministrar aulas de matemática na educação básica impactam na formação de futuros(as) professores(as). A noção de ambiente de aprendizagem é tomada da perspectiva da educação matemática crítica de Ole Skovsmose. A pesquisa não objetivou quantificar esses ambientes, sendo desenvolvida por meio de uma abordagem qualitativa que utilizou com estratégia de produção dos dados a observação e a análise documental dos diários reflexivos. Os dados foram categorizados a partir das aulas observadas pelos residentes durante a fase de imersão no espaço escolar do Programa Residência Pedagógica. Os resultados apontam que os ambientes mobilizados pelo professor impactam na formação dos residentes mostrando a importância: da formação contínua, do domínio do conteúdo traduzido em diferentes estratégias para ensinar, de ações educativas nas quais o estudante é o protagonista e de exercitar uma reflexão sobre a prática.
Editorial
Authors: SAITO FUMIKAZU
Published: January 2023

Editorial
Panorama das teses nacionais e internacionais relacionadas ao Pensamento Algébrico no período entre 2010 e 2019
Authors: SILVA ANDERSON ADELMO DA , BIANCHINI BARBARA LUTAIF
Published: January 2023

Neste estudo inventariamos a produção acadêmica de teses relacionadas ao Pensamento Algébrico delimitando lacunas e tendências da área e contribuindo para o direcionamento de novos estudos. Apresentamos o panorama das teses produzidas no Brasil (quinze), Espanha (seis), Estados Unidos (seis) e Portugal (nove) no período de 2010-2019. Para a análise, destacamos os dados físicos das teses (autor, orientador, país, título e ano de defesa); os aspectos abordados sobre o Pensamento Algébrico, tendo sido abordadas treze características; a relação com a Teoria Elementar dos Números, que não é citada diretamente, tendo sido abordada a Teoria dos Números em dez teses, quatro relacionando temas a serem abordados para desenvolver o Pensamento Algébrico e seis destacando sua importância na formação dos professores; e os Conhecimentos Docentes que foram abordados em onze teses citando quarenta e três obras.
Towards a philosophical foundation of human rights in contemporaneity
Authors: Piemonte Ditão Ygor Pierry , Vavá Cavalcante Antonio , Gobetti Talissa
Published: January 2023

Using bibliographical review and analysis, this article seeks to elaborate upon the philosophical foundations of Human Rights. In order to do so, we conducted a research regarding the jusnaturalist, positivist, moralist and negationist schools in order to present aspects of converging 'concentric circles'. This structure enables the possibility of a shared philosophical foundation of Human Rights instead of multiple theoretical misconceptions emerging from each theory read individually. There is therefore a lesser risk of leading such theories and their interpretations into anachronism and stasis.
Tutela inibitória como instrumento de efetividade do direito ao acesso à justiça em tempos de pandemia
Authors: PAGGIATTO CAMACHO Luciana da Silva , GRANADO Daniel Willian , ARÉVALO Jorge Alfredo , MARTINS José Alberto Monteiro
Published: January 2023

Objetivo: o presente artigo científico tem como finalidade abordar o cenário excepcional imposto pela pandemia decorrente do vírus SarsCov2 – COVID-19 e seus desdobramentos, dos quais decorrem alterações na vida dos cidadãos em relação aos direitos de personalidade, como, por exemplo, a liberdade de ir e vir, o direito à informação e o direito do consumidor, entre outros, em confronto com direitos coletivos para salvaguardar a saúde, como bem primordial da sociedade, por ser um dos elementos que integram o Estado: o território, a soberania e o povo (quiçá vivo).
Metodologia: a metodologia de pesquisa utilizada foi a jurídica-teórica, por meio do raciocínio empírico-dedutivo e da observação da realidade social, estudos do ordenamento jurídico, material bibliográfico doutrinário e jurisprudencial.
Resultados: os resultados obtidos foram respectivamente (i) a necessidade de reflexão e fomento das normas constitucionais para salvaguardar o Estado Democrático de Direito consagrado na Constituição; (ii) a defesa do direitos e garantias do indivíduo, (iii) os direitos da personalidade e outros referenciados; (iv ) a utilização de tutelas inibitórias individuais e coletivas para atingir este mister. E, por fim, de forma sintética, concluiu-se que a tutela inibitório é um meio eficaz para tornar direitos efetivos, principalmente no contexto excepcional imposto pela pandemia.
Contribuições: a contribuição científica almejada é, inicialmente, fomentar o debate sobre os meios de efetivação da tutela jurisdicional na defesa de Direitos materiais, difusos, coletivos e individuais homogêneos, sobre os quais não há a possibilidade de quantificar os danos, em sendo lesionados, por suas características imanentes não patrimoniais e, em um segundo momento, revisar institutos de Direito processual, como as tutelas preventivas, e, em especial, a tutela inibitória, aqui tratada, como meio de salvaguarda desses direitos.
Palavras-Chave: Tutela inibitória. Direito de ação. Tutela jurisdicional diferenciada. Pandemia.
reconhecimento biométrico facial e a utilização pelo Poder Público
Authors: Castro Katia Shimizu de , Veiga de Paula Luciana
Published: January 2023

A biometria facial vem sendo cada vez mais utilizada pelo poder público para reconhecimento dos indivíduos. Apesar dos dados biométricos faciais serem considerados sensíveis, o uso desta tecnologia carece de cuidado no que tange ao direito à privacidade e aos possíveis casos de vieses discriminatórios capazes de trazerem aos seus titulares danos irreparáveis, vez que acontecimentos nessa esfera são constantemente relatados em países que adotaram o uso dessa tecnologia. No Brasil não existe uma legislação específica que regulamente o seu uso, há projetos de lei há anos em tramitação sem que haja, entretanto, qualquer avanço em sua aprovação, no entanto, apesar da lacuna legislação o poder público faz uso constante do reconhecimento facial.
La sémiotique en prise sur le singulier
Authors: Kersyté Nijolé
Published: January 2023

Quel est, selon l’approche structurale, le rapport entre une oeuvre singulière et le système général dont elle relève ? Si on conçoit cette approche comme ayant pour objectif de mettre en évidence et de décrire le système de tous les phénomènes réels, mais aussi possibles, et donc prédictibles, alors tout phénomène particulier (un texte, un discours, une oeuvre, un événement) apparaît comme une simple réalisation d’un schéma, d’un modèle ou d’une structure connue d’avance et a priori. En ce cas, toute « créativité » serait exclue. Mais parmi les divers modèles structuraux, la sémiotique de Greimas fait exception. Elle se distingue par un ensemble de choix épistémologiques et méthodologiques (grammaire générative du discours, description du système en termes syntaxiques et paradigmatiques, sémantique discursive non taxinomique) qui la rendent tout à fait apte à saisir la singularité d’une oeuvre, du moins dès le moment où on la pratique de manière inventive et non pas dogmatique. Les analyses concrètes menées dans ce cadre montrent que la nouveauté ou l’inventivité d’un discours se laisse le mieux saisir sur le plan de la sémantique discursive, considérée dans ses rapports avec la structure narrative.
corporeidade na nova teonomia
Authors: Souza Waldir , Quintas Michel Eriton
Published: January 2023

A corporeidade, em teologia, compreende-se a partir da fronteira entre a sistemática (antropologia) e a moral. Das compreensões do humano às decorrências antropológicas. Assumindo um panorama de valor positivo quanto ao corpo, o presente artigo objetiva discutir sua experiência que, superadas a heteronomia e a mera autonomia, dá espaço, através da Revelação, para a vivência da teonomia. A metodologia empregada é bibliográfica com análise e discussão de conteúdo. Para tanto, foram contemplados os seguintes objetivos: (i) construir uma breve distinção entre heteronomia, autonomia e teonomia; (ii) indicar a compreensão da Revelação como ponto de superação do conflito; e (iii) explorar a aplicação da nova teonomia às experiências do corpo, a sexualidade, o gênero, a família. Desta forma, evidencia-se que as orientações morais cumprirão o papel de formação da consciência e que, somente esta será base da tomada de decisões. Superado o moralismo e o amoralismo, portanto, a prática do amor se abre às possibilidades. Estas que, diante do fracasso, não se sujeitam a resignação, mas abrem-se à novas tentativas. Assim, as experiências dos corpos dissidentes também são compreendidas, das questões da diversidade sexual às novas configurações familiares. Conclui-se, portanto, que a corporeidade, ao encontrar sua plenitude na sexualidade – como dado antropológico – obtém, através da autonomia fundada em Deus, uma moral da qualidade das relações. Complexa, relaciona-se com o discernimento, com a criatividade (ou subversão) fiel. Desta forma, o itinerário da presente reflexão apresenta e elabora argumentos em perspectiva inclusiva e identitária, isto é, reconhecendo a subjetividade como ponto fundamental para a hermenêutica da tradição. Assim, a máxima expressão do corpo dá-se através da teonomia enquanto prática do amor.
Por uma Teologia do Direito Canônico
Authors: Fraga Gomes Tiago de , Demarchi Laudemir
Published: January 2023

A respeito de uma Teologia do Direito Canônico ou Canonística é necessário compreender e analisar o que está implícito no Código de Direito Canônico latino e das Igrejas Orientais. Algumas questões podem justificar, ou não, o fenômeno canônico na Igreja, por exemplo: há necessidade do Direito Canônico eclesial? A Igreja conseguiria levar a cabo a missão de Jesus sem seu Direito próprio e peculiar? O presente artigo busca fundamentar a necessidade de uma Teologia do Direito Canônico, especialmente no contexto pós-conciliar. A nova consciência eclesiológica oriunda do Concílio Vaticano II, além da noção de Direito ou o desenvolvimento de correntes teóricas que tratam do Direito na Igreja, é base para uma Teologia do Direito Canônico.
Crise Humanitária e Consciência Humanitária em Construção
Authors: Passos João Décio
Published: January 2023

As crises humanitárias acompanham a história da humanização como um antídoto persistente. A “descoberta do humano” como valor e norma de convivência civilizada é uma construção em processo. Posturas e regimes atuais assumem narrativas e políticas de negação do humano que colocam em dúvidas supostas seguranças humanitárias institucionalizadas. A revolução humanitária que gestou uma consciência humanitária cada vez mais global resulta uma percepção milenar de fundo religioso e filosófico. Contudo, ela ainda não conheceu sua conclusão e, de fato, não poderá conhecê-la por se tratar de um projeto em permanente construção. A utopia do humano é um horizonte a ser mantido vivo para além de todas as configurações históricas.
silenciamento das mulheres como entrave ao discipulado de Iguais
Authors: Ottaviani Edelcio Serafim , Santinon Ivenise , Mariotti Lucy Terezinha
Published: January 2023

Este artigo procura traçar uma breve genealogia do silenciamento das mulheres na estrutura eclesial. Parte da análise de um retábulo, pintado entre os séculos XII e XIII, e mostra os discursos e as práticas de silenciamento no interior da Igreja, nos oito séculos anteriores e nos oito séculos posteriores à pintura. O silenciamento se apresenta como um elemento decorrente do patriarcalismo enraizado na estrutura eclesial e desvela uma relação de poder que exclui as mulheres dos organismos de decisão. Divido em três tópicos, precedidos por um preâmbulo que analisa os argumentos do retábulo e o lugar destinado à mulher que fala na igreja, o artigo apresenta o silenciamento como um entrave ao discipulado de iguais. Composto a seis mãos, ele entrelaça os objetos de pesquisa do trio de autores envolvidos em sua redação: a análise iconográfica dos três primeiros séculos da era cristã, com ênfase nas transposições artísticas do poder pastoral; o movimento beguinal − tido por movimento de contraconduta, segundo Michel Foucault, e profético, segundo José Comblin, como resistência ao poder clerical; a perspectiva da teologia feminista, sobre os entraves ao discipulado de iguais.
Psychometric analysis of a simplified version of the Emotion Regulation Questionnaire in Mexican adults: The ERQ-CA-9
Authors: Valencia Pablo D. , De la Rosa-Gómez Anabel
Published: January 2023

Background: The Emotion Regulation Questionnaire (ERQ) is the most widely used measure of cognitive reappraisal and expressive suppression, two core emotion regulation strategies. However, the original ERQ has complex wording, which may make it difficult for readers of lower educational levels. Objective: We aimed to examine the psychometric properties of a simplified version of the ERQ, initially designed for children and adolescents: the ERQ-CA. Method: A sample of 397 Mexican adults was studied (77.3% women, 22.7% men; mean age = 22.84). A confirmatory factor analysis, as well as a graded response model, were used to study the internal functioning of the instrument. In addition, its associations with three psychopathological variables (anxiety, depression, and suicidal ideation) were examined. Results: A 9-item version of the ERQ-CA showed adequate fit (CFI = .95, RMSEA = .06), as well as good reliability (ωreappraisal = .76; ωsuppression = .75). Both subscales performed better at levels closer to the mean of their respective constructs. Finally, significant correlations were found between both subscales and the psychopathological variables. Conclusion: The 9-item ERQ-CA constitutes a promising alternative to measure cognitive reappraisal and expressive suppression in the Mexican adult population.
Varicotape: temporary selective varices compression
Authors: Casoni Paolo , Nanni Emanuele , Pizzamiglio Matteo , Ricci Stefano
Published: January 2023

We incidentally hypothesized that placing Kinesio tapes over the bulging varicose veins patients had immediate clinical benefit. Refilling Time prolongation after taping seems the explanation of this effect. Fifteen patients were investigated via a clinical questionnaire and photoplethysmography trying to demonstrate the possibility of this type of temporary selective varices compression as a conservative treatment of varicose veins incompetence syndrome. The results were very encouraging suggesting a rapid divulgation of this simple and cheap method.
Sedative effect with the combination of butorphanol and midazolam on two-dimensional shear wave elastography of pancreas and kidney in healthy dogs
Authors: Cho Hyun , Yang Seung Wha , Suh Guk Hyun , Choi Jihye
Published: January 2023

OBJECTIVE

To evaluate the sedative effect of a combination of butorphanol and midazolam on 2-D shear wave elastography (SWE) of the kidneys and pancreas in dogs.

ANIMALS

8 clinically healthy dogs.

PROCEDURES

We conducted a 2-D SWE examination of the bilateral kidneys and the pancreas before and after IV of 0.2 mg/kg butorphanol and 0.1 mg/kg midazolam in each dog. We performed 2-D SWE on the left kidney via a subcostal approach with the dog in right lateral recumbency, on the right kidney via the intercostal approach with the dog in left lateral recumbency, and on the right lobe of the pancreas via the subcostal approach. Subsequently, the pancreas and kidney shear wave velocities (SWV) pre- and postsedation were compared.

RESULTS

On qualitative evaluation using color mapping, the pancreas and kidneys showed a homogeneous blue-to-green color in pre- and post-sedation 2-D SWE. There was no significant difference in SWV pre- and post-sedation in the pancreas and kidneys.

CLINICAL RELEVANCE

Intravenous administration of a combination of 0.2 mg/kg butorphanol and 0.1 mg/kg midazolam did not change the 2-D SWE of the pancreas and kidneys significantly. The combination of butorphanol and midazolam can be used in healthy dogs for 2-D SWE evaluation of the pancreas and kidneys, especially when the patient is uncooperative during the examination.
Research on the evaluation of historical building values based on historic building mapping
Authors: Wu Juan , Lin Hongjian , Yuxi Saizhi
Published: January 2023

Historic buildings carry the history of human civilisation, and their conservation and utilisation are widely valued by countries around the world. At present, the lack of qualitative and quantitative assessment and evaluation methods for the preservation status and attachment value of historic buildings poses a challenge to the smooth implementation of the conservation and utilisation of historic buildings. The development of a set of system standards for the assessment and evaluation of historic buildings is an urgent task for the conservation and utilisation of historic buildings. This paper proposes a set of comprehensive mapping assessment and evaluation system for historical buildings through the analysis and sorting out of the current situation of preserving historical buildings and their development lineage, architectural style, building type, society and art. Finally, based on the above mapping evaluation system, 20 historical buildings are graded according to the requirements of historical building classification, and according to the different levels. Corresponding conservation measures are proposed and different planning schemes are formulated to better utilise the historical, scientific, cultural and economic values of historical buildings.
Extremal trees for the Randić index
Authors: Jahanbani Akbar , Shooshtari Hajar , Shang Yilun
Published: January 2023

Graph theory has applications in various fields due to offering important tools such as topological indices. Among the topological indices, the Randić index is simple and of great importance. The Randić index of a graph 𝒢 can be expressed as

R

(
G
)

=

∑

x
y
∈
Y

(
G
)

1

τ

(
x
)

τ

(
y
)

R\left( G \right) = \sum\nolimits_{xy \in Y\left( G \right)} {{1 \over {\sqrt {\tau \left( x \right)\tau \left( y \right)} }}}

, where 𝒴(𝒢) represents the edge set and τ(x) is the degree of vertex x. In this paper, considering the importance of the Randić index and applications two-trees graphs, we determine the first two minimums among the two-trees graphs.
Partial sums of the Rabotnov function
Authors: Kazımoğlu Sercan , Deniz Erhan
Published: January 2023

This article deals with the ratio of normalized Rabotnov function ℝα,β (z) and its sequence of partial sums (ℝα,β)
m
(z). Several examples which illustrate the validity of our results are also given.
Three-Point Iterated Interval Half-Cutting for Finding All Local Minima of Unknown Single-Variable Function
Authors: Romanuke Vadim
Published: January 2023

A numerical method is suggested to find all local minima and the global minimum of an unknown single-variable function bounded on a given interval regardless of the interval length. The method has six inputs: three inputs defined straightforwardly and three inputs, which are adjustable. The endpoints of the initial interval and a formula for evaluating the single-variable function at any point of this interval are the straightforward inputs. The three adjustable inputs are a tolerance with the minimal and maximal numbers of subintervals. The tolerance is the secondary adjustable input. Having broken the initial interval into a set of subintervals, the three-point iterated half-cutting “gropes” around every local minimum by successively cutting off a half of the subinterval or dividing the subinterval in two. A range of subinterval sets defined by the minimal and maximal numbers of subintervals is covered by running the threepoint half-cutting on every set of subintervals. As a set of values of currently found local minima points changes less than by the tolerance, the set of local minimum points and the respective set of function values at these points are returned. The presented approach is applicable to whichever task of finding local extrema is. If primarily the purpose is to find all local maxima or the global maximum of the function, the presented approach is applied to the function taken with the negative sign. The presented approach is a significant and important contribution to the field of numerical estimation and approximate analysis. Although the method does not assure obtaining all local minima (or maxima) for any function, setting appropriate minimal and maximal numbers of subintervals makes missing some minima (or maxima) very unlikely.
On the Development of Long-Range Water Quality Monitoring System for Outdoor Aquaculture Objects
Authors: Pikulins Dmitrijs , Gotlaufs Roberts , Solovjova Tatjana , Aboltins Arturs , Grizāns Juris , Migla Sandis
Published: January 2023

The paper is dedicated to the development of hardware and software components for the autonomous water quality monitoring system (WQMS) for fishing farms. The system can measure main water quality parameters, storing and processing data on the remote server. The LoRaWAN technological solutions and infrastructure are utilized, providing the optimal tradeoff between data transmission range and adaptive power consumption. The main implementation and exploitation issues are described, and the proposed solutions are provided.
Trichotomization with two cutoff values using Kruskal-Wallis test by minimum P-value approach
Authors: Ogura T. , Shiraishi C.
Published: January 2023

In clinical trials, age is often converted to binary data by the cutoff value. However, when looking at a scatter plot for a group of patients whose age is larger than or equal to the cutoff value, age and outcome may not be related. If the group whose age is greater than or equal to the cutoff value is further divided into two groups, the older of the two groups may appear to be at lower risk. In this case, it may be necessary to further divide the group of patients whose age is greater than or equal to the cutoff value into two groups. This study provides a method for determining which of the two or three groups is the best split. The following two methods are used to divide the data. The existing method, the Wilcoxon-Mann-Whitney test by minimum P-value approach, divides data into two groups by one cutoff value. A new method, the Kruskal-Wallis test by minimum P-value approach, divides data into three groups by two cutoff values. Of the two tests, the one with the smaller P-value is used. Because this was a new decision procedure, it was tested using Monte Carlo simulations (MCSs) before application to the available COVID-19 data. The MCS results showed that this method performs well. In the COVID-19 data, it was optimal to divide into three groups by two cutoff values of 60 and 70 years old. By looking at COVID-19 data separated into three groups according to the two cutoff values, it was confirmed that each group had different features. We provided the R code that can be used to replicate the results of this manuscript. Another practical example can be performed by replacing x and y with appropriate ones.
The application of PSO-BP combined model and GA-BP combined model in Chinese and V4’s economic growth model
Authors: Gui X. , Fečkan M. , Wang J. R.
Published: January 2023

This paper adopts different optimization algorithms such as Genetic Algorithm (GA) and Particle Swarm Optimization Algorithm (PSO-Algorithm) to train Back-Propagation (BP) neural networks, fits the Chinese, the Czech, Slovak, Hungarian, and Polish gross domestic product (GDP) growth model (from 1995 to 2020) and makes short-term simulation predictions. We use the PSO-Algorithm and GA with strong global search ability to optimize the weights and thresholds of the network, combine them with the BP neural network, and apply the resulting Particle Swarm Optimization Back-Propagation (PSO-BP) combined model or Genetic-Algorithm Back-Propagation (GA-BP) combined model to allow the network to achieve fast convergence. Besides, we also compare the above two hybrid models with standard multivariate regression model and BP neural network with different initialization methods like normal uniform and Xavier for fitting and short-term simulation predictions. Finally, we obtain the excellent results that all the above models have achieved a good fitting effect and PSO-BP combined model on the whole has a smaller error than others in predicting GDP values. Through the technology of PSO-BP and GA-BP, we have a clearer understanding of the five countries gross domestic product growth trends, which is conducive to the government to make reasonable decisions on the economic development.
A heteroscedastic Bayesian model for method comparison data
Authors: Lakmali S. M. M. , Nawarathna L. S. , Wijekoon P.
Published: January 2023

When implementing newly proposed methods on measurements taken from a human body in clinical trials, the researchers carefully consider whether the measurements have the maximum accuracy. Further, they verified the validity of the new method before being implemented in society. Method comparison evaluates the agreement between two continuous variables to determine whether those measurements agree on enough to interchange the methods. Special consideration of our work is a variation of the measurements with the magnitude of the measurement. We propose a method to evaluate the agreement of two methods when those are heteroscedastic using Bayesian inference since this method offers a more accurate, flexible, clear, and direct inference model using all available information. A simulation study was carried out to verify the characteristics and accuracy of the proposed model using different settings with different sample sizes. A gold particle dataset was analyzed to examine the practical viewpoint of the proposed model. This study shows that the coverage probabilities of all parameters are greater than 0.95. Moreover, all parameters have relatively low error values, and the simulation study implies the proposed model deals with the higher heteroscedasticity data with higher accuracy than others. In each setting, the model performs best when the sample size is 500.
Customer Satisfaction and Switching Intentions of Banking Services End-Users in Montenegro
Authors: Jovović Milorad , Mišnić Nikola , Pejović Bojan , Mijušković Marija
Published: January 2023

Numerous research studies of the various companies’ business practices indicate a strong relationship between customer satisfaction, as an overall positive response generated after the use of the specific product or service, and their intention to continue using the products/services of the company. As a rule, satisfied and particularly delighted customers show intention to return and become loyal, whereas dissatisfied and disappointed customers have switching intentions. Therefore, the objective of this study is to empirically test to which extent the intention to switch banks in Montenegro depends on customer satisfaction or dissatisfaction. With this regard, we have posed a question inquiring about the level of consumers satisfaction/dissatisfaction with banking services in Montenegro, what their intentions are regarding the continuation of using services of the chosen bank (customer retention & defection), and to what extent customer satisfaction and dissatisfaction determine their intention to change the bank. The analysis has established a statistically significant correlation between satisfaction, dissatisfaction, and intentions of leaving the bank. Findings has shown a relatively high level of customer satisfaction with banking services in Montenegro, as well as confirming that dissatisfaction usually leads to the intention to leave and change the bank, while satisfaction leads to the continued use of the bank’s services. A high level of competition in the banking services market as well as the struggle for each consumer makes this topic undeniably current and this research represents a significant input for the bank management in Montenegro regarding the identification of the real situation with customer satisfaction and their intention to switch banks in accordance with their level of satisfaction.
Clinical Mastits Incidence In Small-Scale Dairy Cow Farms
Authors: Janevski Aleksandar , Nikolovski Martin , Cvetkovikj Iskra , Andreevska Silvana , Todorovski Angjelche , Mitrov Dine
Published: January 2023

The incidence of clinical mastitis (CM) in small and large-scale dairy cow farms can be highly variable and can be affected by age, parity, post-calving status, and atmospheric conditions. The current study aimed to assess the CM-incidence and its association with the post-calving days, number of lactations, season, and number of affected udder quarters in dairy cows in small-scale dairy farms. The study was conducted within one calendar year in 177 small-scale farms with 864 dairy cows. Clinically confirmed CM cows (n=72) were sampled from each udder quarter and processed for bacteriology examination. The CM-positive samples were grouped according to the season (spring, summer, autumn, and winter), the number of days after calving (<90, 90-180, and >180), the number of lactations (1-st, 2-5-th, and >6-th), and the number of affected udder quarters (one, two, three, and four). The CM-positive samples (n=72, 8.3%) were confirmed on bacteriology examination in significantly lower count (n=56, 6.5%). The 2-5-th lactations cows (n=35, 68.6%) were significantly more compared to the first lactation (n=6, 11.8%), and >6-th lactation cows (n=10, 19.6%). CM cows with infection of one udder quarter (n=40, 78.4%) were significantly more than the cows with two (n=6, 11.8%), and four infected quarters (n=5, 9.8%). The CM-incidence in small-scale dairy cow farms in North Macedonia was 8.3% and 6.5% by clinical and bacteriology examination, respectively. The highest CM susceptibility was observed in the cows between the second and fifth lactations. One udder quarter was most frequently affected in CM-positive cases.
Intermediates derived from p-terphenyl in the methyltributylammonium bis[(trifluoromethyl)sulfonyl]imide ionic liquid saturated with carbon dioxide: Pulse radiolysis study
Authors: Kocia Rafał
Published: January 2023

Radiation-induced processes in ionic liquid (IL) methyltributylammonium bis[(trifluoromethyl)sulfonyl] imide ([MeBu3N][NTf2]) solutions containing p-terphenyl (TP) and saturated with carbon dioxide (CO2) were studied using nanosecond pulse radiolysis technique with UV-vis detection. The transient absorption spectra generated in these solutions were assigned to TP radical anions (TP•−) and triplet excited states (3TP*). Saturation of [MeBu3N][NTf2] solutions with carbon dioxide efficiently takes out presolvated electrons

(

e

presolv

−

)

( {{\rm{e}}_{{\rm{presolv}}}^ - } )

and solvated electrons

(

e

solv

−

)

( {{\rm{e}}_{{\rm{solv}}}^ - } )

. On the other hand CO2 is not a scavenger of excited states of TP (1TP*, 3TP*), which in the reaction with triethylamine (TEA) leads to the formation of TP•−.
Simulation as Tool for Logistic Chain Optimization
Authors: Klapita Vladimír
Published: January 2023

Simulation is one of the methods in which a real system is substituted with a computer model where experiments are practiced and then subsequently analyzed and evaluated. After the application of the results of simulation and verification of its effects the results are applied in the real system with the aim to optimize processes. It seems that simulation is appropriate tool which offers all useful information about how model system works in given conditions. Simulation in planning and optimizing allows better and faster understanding of processes and guarantees that operational devices will work at the top of their effectiveness. Simulation plays an important role in optimization of logistic chains organization. There is a need to analyze strictly, find narrow places, remove them and consequently to repeat simulation with the new data. It is also very profitable to parallelly simulate more possible alternatives when there is a change in input data and consequently to compare them. The model of logistic chain created by simulation will considerably influence right decisions in process solving related to distribution. Subsequent optimization of logistic chain management can be aimed at the organization where the sum of final costs for transport and warehousing is minimum in compliance with basic parameters of customers’ service level.

In the paper classic systems of the management of logistic chains are compared, namely direct distribution and indirect distribution made by technology Cross-Dock canter. Final comparative analysis of both systems simulation points out not only to their advantages and disadvantages but also to the possibilities of their optimization and application in particular operational conditions.
Otitis media supuratif kronis maligna dengan komplikasi paresis nervus fasialis perifer: Studi kasus
Authors: Valentina Eunike Alicia , Wicaksono Ardhian Noor
Published: January 2023

Otitis media supuratif kronis (OMSK) adalah peradangan kronis pada telinga tengah dan mukosa mastoid. Manifestasi klinis OMSK terbagi menjadi 2 jenis, yaitu benigna dan maligna. Pada OMSK maligna, morbiditas dan mortalitas cenderung tinggi karena adanya kolesteatoma yang bersifat destruktif terhadap tulang. Paresis nervus fasialis adalah salah satu komplikasi intrakranial OMSK maligna yang terjadi ketika kolesteatoma mengerosi tulang kanalis fasialis. Keterlambatan diagnosis dan penatalaksanaan komplikasi OMSK dapat mempengaruhi morbiditas, mortalitas dan kualitas hidup pasien. Studi kasus ini menggambarkan pasien perempuan berusia 37 tahun yang datang dengan keluhan wajah sebelah kiri tertarik (‘perot’) disertai pipi kanan yang bengkak dan nyeri. Pasien memiliki riwayat keluhan nyeri telinga yang disertai keluarnya cairan dari telinga. Pasien kemudian didiagnosis OMSK maligna auris dextra dengan komplikasi paresis nervus fasialis perifer. Pasien diterapi dengan antibiotik, kortikosteroid, dan analgesik, serta dirujuk untuk tindakan mastoidektomi. Setelah mendapatkan terapi medikamentosa, bengkak dan nyeri pada wajah berkurang. Pasien juga dapat berbicara lebih jelas dibanding ketika pertama kali datang ke rumah sakit. Kesembuhan paresis nervus fasialis perifer akibat OMSK sangat bergantung pada seberapa cepat pasien memperoleh terapi definitif.
Profil Pasien Tuberkulosis Paru tanpa dan dengan Diabetes Melitus di RSUD Sungai Dareh Dharmasraya
Authors: Pradinda Mustika Dita , Russilawati Russilawati , Ilhami Yose Ramda
Published: January 2023

Latar Belakang: Tuberkulosis (TB) merupakan penyakit infeksi menular yang menjadi salah satu penyebab utama kematian di dunia. Salah satu komorbid dari TB adalah penyakit Diabetes Melitus (DM).
Objektif: Penelitian ini bertujuan untuk mengetahui profil pasien Tuberkulosis paru tanpa dan dengan Diabates Melitus di RSUD Sungai Dareh Dharmasraya.
Metode: Penelitian ini merupakan penelitian deskriptif restrospektif dengan pengambilan sampel menggunakan teknik total sampling. Sampel diambil dari rekam medik pasien yang didiagnosis TB paru tahun 2020 di RSUD Sungai Dareh Dharmasraya.
Hasil: Hasil penelitian didapatkan 74 pasien TB paru tanpa DM dan 21 pasien TB-DM. Penelitian ini menunjukkan kelompok umur terbanyak pasien TB paru tanpa DM 35-44 tahun (28,4%) dan pada pasien TB-DM 45-54 tahun (33,3%). Jenis kelamin laki-laki paling banyak pada TB paru tanpa dan dengan DM (60,8% : 85,7%) serta status IMT adalah underweight (63,5% : 52,4%). Gejala klinis terbanyak pada TB paru tanpa DM adalah batuk (74,3%) dan TB-DM adalah sesak napas (76,2%). Hasil BTA sputum terbanyak pada TB paru tanpa DM adalah 3+ (37,8%) dan pada TB-DM adalah 1+ (38,1%). Hasil TCM TB Paru tanpa dan dengan DM terbanyak adalah Mtb detected Rif resisten not detected (83,8% : 76,2%). Hasil radiologi terbanyak pada TB paru tanpa DM di lapangan atas paru (18,9%) tanpa kavitas (60,8%) sementara pada TB-DM di lapangan bawah paru (28,5%) tanpa kavitas (61,9%).
Kesimpulan: Sebagian besar pasien TB paru dengan DM mengeluhkan gejala klinis sesak napas, dan pada pasien TB paru tanpa DM lebih banyak mengeluhkan batuk.
Hubungan Obesitas dengan Kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil Padang
Authors: Helmi Iqbal Muhammad , Sulastri Delmi , Mulyana Roza
Published: January 2023

Latar Belakang: Gastroesophageal Reflux Disease merupakan kondisi patologis akibat refluks kandungan lambung ke esofagus yang terjadi berulang kali. Kondisi obesitas dapat meningkatkan tekanan intra-abdomen dan menurunkan fungsi esofagus serta Lower Esophageal Sphincter sehingga risiko Gastroesophageal Reflux Disease akan meningkat.
Objektif: Penelitian ini bertujuan untuk melihat hubungan antara obesitas dan kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil Padang tahun 2018-2019.
Metode: Jenis penelitian ini adalah analitik observasional menggunakan pendekatan retrospektif dengan rancangan penelitian case-control study yang telah berlangsung dari bulan November hingga Desember 2021 di Instalasi Rekam Medis RSUP Dr. M. Djamil Padang. Penelitian ini menggunakan teknik pengambilan simple random sampling dengan jumlah sampel sebanyak 38 pasien kelompok kasus dan 38 pasien kelompok kontrol. Penelitian ini dilakukan menggunakan uji Chi-Square dengan cara membandingkan frekuensi penderita obesitas pada kelompok kasus dan kontrol.
Hasil: Hasil penelitian ini memperoleh 52,6% kelompok kasus mederita obesitas dan 10,5% kelompok kontrol menderita obesitas. Berdasarkan uji Chi-square, terdapat hubungan yang bermakna antara obesitas dengan kejadian Gastroesophageal Reflux Disease (p=0,001, OR=9,444).
Kesimpulan: Kesimpulan pada penelitian ini adalah terdapat hubungan yang bermakna antara obesitas dengan kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil.
Green tourism in Ukraine, formation, development and prospects
Authors: Marchyshyn Nazar , Ostrovskaya Nadiya
Published: January 2023

The article is devoted to the problem of the development of green tourism in Ukraine. Green tourism is an important part of rational nature management, which involves the creation and maintenance of recreational systems, including supporting the development of destinations by improving their ecological and general culture. The purpose of the study is to identify and analyze the vectors of formation, development and promising directions for the development of green tourism tour products. Research objectives: 1) to identify the relevance of the problem; 2) consider the concepts, features, types and functions of green tourism; 3) study the main determinants of the development of tourism potential in Ukraine; 4) develop proposals regarding the prospects for the development of green tourism on the territory of Ukraine. To achieve the goal of the article, a number of methods of scientific knowledge were used, namely: analysis of scientific literature, induction, deduction, synthesis, generalization, comparison.

The development of green tourism requires the implementation of mandatory strategic and territorial planning for each individual territory within the administrative and territorial units of our country, the creation of the necessary infrastructure in rural areas, the implementation of an individual marketing strategy, monitoring the consequences of the growth of tourist flows, the involvement of the local population, and the development of volunteerism. Based on the relationship to green tourism as an economic category, it is possible to define green tourism as a component of the tourism industry, which produces and sells its tourism product and receives profit from it, or as a tourist activity in rural areas that brings profit for the preservation of the natural environment, and also to improve the standard of living of the local population. The most promising direction for improving the green tourism management system at the regional level is the creation of regional tourism administrations.

The conducted analysis provides an opportunity to talk about Ukraine as a country that has great potential for the formation of a successful segment of green tourism. The main development problem is the lack of a strategy for the development of green tourism and, as a result, there are no precisely established tasks and goals facing this area. Taking into account the determining importance of green tourism for the development of tourism in Ukraine, it is necessary to create a cluster "Green tourism in rural areas of Ukraine". For these purposes, it is necessary to make changes to the program of the development of inbound and domestic tourism with the establishment of specific tasks and goals that are in the green tourism, with clarification of effective mechanisms for their implementation and a plan of activities for the development of the cluster.