bluuebunny/crossref_metadata_2025 huggingface dataset:
School and non‐school day screen time profiles and their differences in health and educational indicators in adolescents
Authors: Sánchez‐Miguel Pedro Antonio , Sevil‐Serrano Javier , Sánchez‐Oliva David , Tapia‐Serrano Miguel Angel
Published: July 2022

Sedentary behavior and screen‐based devices in particular have been negatively associated with a wide range of health and educational indicators. However, few have examined these relationships separately for school days and non‐school days, and none have used a person‐centered approach. This study aimed to identify school and non‐school day screen time profiles, as well as examine possible differences in health indicators (physical fitness, fatness, physical activity, sleep duration, and Mediterranean diet) and academic performance. This study involved the participation of 1573 Spanish adolescents aged 12–16 years (54.73% girls). Academic performance was measured through grades in Mathematics, Language, English, and Physical Education. Physical fitness was measured through a battery of tests (cardiorespiratory fitness was measured using the 20 m shuttle run test, and muscular strength with both handgrip and standing long jump tests), while fatness (skinfold thicknesses) was assessed with calipers. Finally, physical activity, screen time, sleep duration, and adherence to the Mediterranean diet were measured using self‐reported questionnaires. Hierarchical cluster analyses based on square Euclidian distances and Ward's method were performed based on daily minutes of screen time recorded on school and non‐school days. We identified four clusters labeled and described as: (1) “High‐high”: highest screen time on school and non‐school days; (2) “High‐low”: high screen time on school days and low screen time on non‐school days; (3) “Low‐high”: low screen time on school days and high screen time on non‐school days; (4) “Low‐low”: lowest screen time on school and non‐school days. Adolescents who belonged to the “High‐high” profile had worse health‐related behaviors (i.e., physical activity, sleep duration, and adherence to Mediterranean diet) and academic performance than most other profiles, while adolescents who belonged to “Low‐low” profile showed the opposite pattern. Adolescents in the “Low‐high” profile had a higher sleep duration on school days and better academic performance than those in the “High‐low” profile. No differences in body fat, cardiorespiratory fitness, and muscular strength were found between the four different profiles. The results suggest that adolescents who accumulated a large amount of screen time on school and non‐school days reported worse health‐related behaviors and academic performance. Moreover, adolescents who had high screen time on school days reported only a short sleep duration on school days and worse academic performance than on non‐school days. Conducting interventions to reduce screen time in these four profiles, particularly in the groups of students with more screen time on school days, becomes essential to improving adolescents' healthy lifestyles and academic performance.
Torsion points on isogenous abelian varieties
Authors: Dill Gabriel A.
Published: July 2022

Investigating a conjecture of Zannier, we study irreducible subvarieties of abelian schemes that dominate the base and contain a Zariski dense set of torsion points that lie on pairwise isogenous fibers. If everything is defined over the algebraic numbers and the abelian scheme has maximal variation, we prove that the geometric generic fiber of such a subvariety is a union of torsion cosets. We go on to prove fully or partially explicit versions of this result in fibered powers of the Legendre family of elliptic curves. Finally, we apply a recent result of Galateau and Martínez to obtain uniform bounds on the number of maximal torsion cosets in the Manin–Mumford problem across a given isogeny class. For the proofs, we adapt the strategy, due to Lang, Serre, Tate, and Hindry, of using Galois automorphisms that act on the torsion as homotheties to the family setting.
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates
Authors: Devanathan Aaron S. , White Nicole R. , Desyaterik Yury , De la Cruz Gabriela , Nekorchuk Michael , Terry Margaret , Busman-Sahay Kathleen , Adamson Lourdes , Luciw Paul , Fedoriw Yuri , Estes Jacob D. , Rosen Elias P. , Kashuba Angela D. M.
Published: July 2022

Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucidate the relationship between antiretrovirals (ARVs) and viral expression in the spleen.
Supercharged MPNs? Automated Determination of High-Throughput Most Probable Number (htMPN) Using Chip-Based 3D Digital PCR
Authors: Wang Zhiying , Zhu Tongbo , Simpson David J. , Gänzle Michael G.
Published: July 2022

htMPN uses chip-based fluorescence acquisition and is a simple and compact tool for automatic viable cell enumeration with applications in microbiological research. This method applies to a wide range of anaerobic or facultative anaerobic species and improves accuracy by reducing the number of pipetting steps.
Primordial Capsid and Spooled ssDNA Genome Structures Unravel Ancestral Events of Eukaryotic Viruses
Authors: Munke Anna , Kimura Kei , Tomaru Yuji , Wang Han , Yoshida Kazuhiro , Mito Seiya , Hongo Yuki , Okamoto Kenta
Published: July 2022

Single-stranded DNA (ssDNA) viruses are an extremely widespread group of viruses that infect diverse hosts from all three domains of life, consequently having great economic, medical, and ecological importance. In particular, bacilladnaviruses are highly abundant in marine sediments and greatly influence the dynamic appearance and disappearance of certain algae species.
IgD lambda multiple myeloma causing hyperammonaemia with possibly reduced ammonium excretion
Authors: Isse Naohi , Nakahara Kei , Sasai Ryutaro
Published: July 2022

A man in his 70s presented with impaired consciousness due to hyperammonaemia while investigating multiple tumours in his brain, chest, spine and right adrenal gland. He did not have any disorders causing hyperammonaemia, such as liver dysfunction, urea-producing bacterial infection or any medications interfering with ammonium metabolism. Blood and urine tests in addition to tumour biopsy specimens confirmed immunoglobulin D lambda multiple myeloma. His general status responded to chemotherapy using bortezomib, dexamethasone and daratumumab, and he subsequently regained full consciousness and a normalised serum ammonia level. He, unfortunately, died of refractory multiple myeloma with hyperammonaemia. The autopsy specimen revealed lambda light-chain deposits in the distal tubule epithelium with cast precipitation and intact liver cells. Urine osmolality gap analysis suggested possibly reduced urinary ammonium excretion, but further investigation is necessary to elucidate the significance of pathological renal characteristics in multiple myeloma with hyperammonaemia.
NIR fluorescence imaging and treatment for cancer immunotherapy
Authors: Kang Homan , Kang Min-Woong , Kashiwagi Satoshi , Choi Hak Soo
Published: July 2022

Cancer immunotherapy has emerged as one of the most powerful anticancer therapies. However, the details on the interaction between tumors and the immune system are complicated and still poorly understood. Optical fluorescence imaging is a technique that allows for the visualization of fluorescence-labeled immune cells and monitoring of the immune response during immunotherapy. To this end, near-infrared (NIR) light has been adapted for optical fluorescence imaging because it is relatively safe and simple without hazardous ionizing radiation and has relatively deeper tissue penetration into living organisms than visible fluorescence light. In this review, we discuss state-of-the-art NIR optical imaging techniques in cancer immunotherapy to observe the dynamics, efficacy, and responses of the immune components in living organisms. The use of bioimaging labeling techniques will give us an understanding of how the immune system is primed and ultimately developed.
Prediction of 90 day home time among patients with low baseline ASPECTS undergoing endovascular thrombectomy: results from Alberta’s Provincial Stroke Registry (QuICR)
Authors: Singh Nishita , Holodinsky Jessalyn K , Kashani Nima , McDonough Rosalie V , Bala Fouzi , Horn MacKenzie , Stang Jillian , Demchuk Andrew M , Hill Michael D , Almekhlafi Mohammed A
Published: July 2022

Background

The benefit of endovascular thrombectomy (EVT) in stroke patients with a low baseline Alberta Stroke Program Early CT Score (ASPECTS, ≤5) is uncertain. We aim to use random forest regression modeling to predict 90 day home time in patients with low ASPECTS.

Methods

We used the Quality Improvement and Clinical Research (QuICR) provincial stroke registry and administrative data from southern Alberta to identify patients who underwent EVT in our center from July 2015 to November 2020. Baseline ASPECTS on non-contrast CT and CT angiography data were scored by a two physician consensus. The primary outcome was the predicted 90 day home time (the number of nights a patient is back at their premorbid living situation without an increase in level of care within 90 days of the stroke) using random forests regression. Estimates were generated using 200 bootstrapped datasets. Covariate contribution to home time was determined using partial dependence plots.

Results

Of 657 EVT patients, 85 (12.9%) had baseline ASPECTS ≤5 (mean age 70.9 years, 44.7% women, 93.9% good–moderate collaterals, 60% M1–middle cerebral artery occlusion). Using partial dependence estimates, mean predicted home times were similar in the low ASPECTS (44.3 days) versus higher ASPECTS (43.1) groups. Factors predicting lower 90 day home time in this population were diabetes mellitus (−8.8 days), hypertension (−5.7 days), and atrial fibrillation (−3.6 days). There was no meaningful difference in predicted 90 day home time by sex, baseline National Institutes of Health Stroke Severity Scale score, occlusion site, tandem lesion, collateral grade or thrombolysis.

Conclusions

Patients with low ASPECTS who are selected for EVT using demographic and clinical profiles similar to higher ASPECTS patients achieved comparable outcomes.
Exploring the relationship between resting-state intra-network connectivity and accelerometer-measured physical activity in pediatric concussion: a cohort study
Authors: Sharma Bhanu , Obeid Joyce , DeMatteo Carol , Noseworthy Michael D. , Timmons Brian W.
Published: July 2022

Our objective was to explore the association between resting-state functional connectivity and accelerometer-measured physical activity in pediatric concussion. Fourteen children with concussion (aged 14.54 ± 2.39 years, 8 female) were included in this secondary data analysis of a larger study. Participants had neuroimaging at 15.3 ± 6.7 days postinjury and subsequently a mean of 11.1 ± 5.0 days of accelerometer data. Intra-network connectivity of the default mode network (DMN), sensorimotor network (SMN), salience network (SN), and frontoparietal network (FPN) was computed using resting-state MRI. We found that, per general linear models (GLMs), only intra-network connectivity of the DMN was associated with physical activity levels. More specifically, increased intra-network connectivity of the DMN was significantly associated with higher levels of subsequent accelerometer-measured light physical activity (LPA; F(2, 11) = 7.053, p = 0.011, Ra2 = 0.562; β = 0.469), moderate physical activity (MPA; F(2, 11) = 6.159, p = 0.016, Ra2 = 0.528; β = 0.725), and vigorous physical activity (VPA; F(2, 11) = 10.855, p = 0.002, Ra2 = 0.664; β = 0.792). Intra-network connectivity of the DMN did not significantly predict sedentary time. Therefore, these preliminary findings suggest that there is a positive association between the intra-network connectivity of the DMN and device-measured physical activity in children with concussion.
Effects of aldo-keto reductase family 1 member A on osteoblast differentiation associated with lactate production in MC3T3-E1 preosteoblastic cells
Authors: Kuo Chia-Hsiao , Lee Inn-Chi , Huang Bo-Jun , Chen Chuan-Mu , Liou Ying-Ming
Published: July 2022

Aldo-keto reductase family 1 member A (AKR1A) is an NADPH-dependent aldehyde reductase widely expressed in mammalian tissues. In this study, induced differentiation of MC3T3-E1 preosteoblasts was found to increase AKR1A gene expression concomitantly increased NOx− (nitrite + nitrate), increased glucose uptake, increased [NAD(P)+]/[NAD(P)H] and lactate production but decreased reactive oxygen species (ROS) without changes in endothelial nitric oxide synthase (eNOS) expression in differentiated osteoblasts (OBs). A study using gain- and loss-of-function MC3T3-E1 cells indicated that AKR1A is essential for modulating OB differentiation and gene expression of collagen 1 A1, receptor activator of nuclear factor kappa-B ligand, and osteoprotegerin in OBs. Immunofluorescence microscopy also revealed that changes in AKR1A expression altered extracellular collagen formation in differentiated OBs. Consistently, analyses of alkaline phosphatase activity and calcium deposits of matrix mineralization by Alizarin Red S staining verified that AKR1A is involved in the regulation of OB differentiation and bone matrix formation. In addition, AKR1A gene alterations affected the levels of NOx−, eNOS expression, glucose uptake, [NAD(P)+]/[NAD(P)H] dinucleotide redox couples, lactate production, and ROS in differentiated OBs. Herein, we report that AKR1A-mediated denitrosylation may play a role in the regulation of lactate metabolism as well as redox homeostasis in cells, providing an efficient way to quickly gain energy and to significantly reduce oxidative stress for OB differentiation.
Mechanical behavior of Malan loess under unconfined compression conditions
Authors: He Shengdi , Li Yanrong , Zhang Shuai
Published: July 2022

Loess landslides result in heavy casualties and economic losses. Among them, toppling is one of the predominant failure modes in Malan loess. Loess toppling failure normally arises from deep vertical cracks, which tend to develop in the shoulder areas of loess slopes and extend to a depth of several meters. Under natural conditions, loess’ static lateral pressure coefficient is low and the loess mass within a 2 m horizontal depth from the slope surface approximates an unconfined compression stress state. In this work, we sought to further examine this unconfined compression state using acoustic emission monitoring and in situ computed tomography scans to investigate the mechanical behavior of Malan loess. Results indicated that Malan loess failed under compression-induced tension in unconfined compression condition. It exhibited the brittle failure with an abrupt release of elastic energy. The failure plane was at large angles and occurred nearly along the loading axis. This result coincided well with the vertiloess structure, which is characterized by vertically aligned strong units and weak segments. The above failure mode supports the formation of vertical cracks in the loess strata and consequently the toppling and crack sliding slope failures, as well as the formation of loess walls and columns.
Experimental investigation of vibration-induced shear resistance reduction in sheared granular soils
Authors: Xie Tao , Guo Peijun , Stolle Dieter
Published: July 2022

To investigate the characteristics of vibration-induced shear resistance reduction (ViSRR) in granular soils, laboratory tests were performed using a modified triaxial apparatus. Monotonic loading and vibration with controlled frequency and acceleration amplitude were superimposed to soil specimens under drained conditions. Tests were conducted for dry and saturated specimens at relative densities of Dr = 35% and 70%. The tests revealed that superimposed vibration causes a reduction of shear resistance in addition to an additional volume change of the specimen. After the termination of vibration, the shear resistance was found to be recovered as the monotonic shearing continued. It was confirmed that the shear resistance reduction was not caused by vibration-induced variation of excess pore pressure in the specimen. For high-frequency vibration with frequency varying between 60 and 120 Hz, the relative shear resistance loss tended to increase linearly with the peak acceleration. Based on the test results, the concept of “vibro-critical state” is proposed to describe the ViSRR of granular soil subjected to monotonic shear and vibration simultaneously.
The effect of feed efficiency classification on visceral organ mass in finishing steers
Authors: Cunningham-Hollinger Hannah C. , Gray Zebadiah T.L. , Christensen Kelcey W. , Means Warrie J. , Lake Scott L. , Paisley Steve I. , Cammack Kristi M. , Meyer Allison M.
Published: July 2022

Individual feed intake of crossbred beef steers (one contemporary group/year, 2 years) was recorded during finishing to investigate visceral organ mass in steers divergent for feed efficiency. Based on residual feed intake (RFI), the 20% most efficient (HE, n = 8/year) and 20% least efficient (LE; n = 8/year) steers with 12th rib fat ≥1.02 cm were slaughtered. High efficiency steers had less DM intake ( P < 0.001), greater G:F ( P < 0.001), and similar ADG and hot carcass weight (HCW). High efficiency steers tended to have less ( P ≤ 0.10) small intestinal mass (actual and relative to BW and HCW) in year 1. In year 2, HE steers tended to have greater ( P ≤ 0.10) large intestinal actual and relative masses. Low efficiency steers tended to have greater ( P = 0.06) actual omasum mass and had greater ( P ≤ 0.03) relative omasum masses compared with HE. Stomach complex, total gastrointestinal tract, liver, and kidney masses tended to be greater ( P ≤ 0.10) relative to BW, and were greater ( P ≤ 0.05) relative to HCW, in LE. Data suggest that visceral organ mass, especially of the gastrointestinal tract, plays a role in overall metabolic efficiency of finishing steers.
An efficient multi-objective optimization framework to maintain road networks based on Bayesian optimization and reliability theory
Authors: Altarabsheh Ahmad , Altarabsheh Ibrahim , Altarabsheh Sara
Published: July 2022

This study proposes an efficient asset management framework that enables decision makers to prioritize the maintenance of their roads, while focusing on the most critical road segments. In particular, this study first extends the application of reliability theory to estimate the overall network condition. Following that, this study proposes a new consequence of failure function for the whole road network based on road segments’ reliability, age, and road agency preferences. Finally, the study proposes an efficient multi-objective optimization algorithm, with the goal of maximizing overall network performance with the least maintenance and computational cost. The suggested framework was applied to three main roads in Jordan and validated statistically by comparing its performance to that of a typical multi-objective genetic algorithm (GA) under various scenarios and utilizing multiple performance metrics. The results show that the proposed algorithm outperforms the traditional GA in terms of objective function values, convergence, and solution spread.
Geochronology, geochemistry, and Hf isotopic compositions of the Early Devonian Heihaibei granite in the East Kunlun Orogen, Northwest China
Authors: Lu Haifeng , Pan Tong , Jiao He , Ding Qing-feng , Zheng Tao , Zhou Xuan , Wu Ruizhe
Published: July 2022

The East Kunlun Orogen (EKO) is located in the western part of the Central Asian Orogenic Belt, and it records the Neoproterozoic–Early Devonian tectonic evolution involving the subduction and extinction of the Proto-Tethys Ocean. The Heihaibei granite is located in the South Kunlun belt within EKO. In this study, geochronology, geochemistry, and Hf isotope analysis of Heihaibei monzogranite and granodiorite were carried out. Their LA-ICP-MS zircon U-Pb results yielded ages of 414.1 ± 2.0 and 417.8 ± 2.0 Ma. The Heihaibei granite is peraluminous (A/CNK = 0.99–1.30), with high alkali contents (7.76–9.14 wt.%) and 10 000 Ga/Al (2.60–3.38), FeOT/MgO (27.6–49.5), and Y/Nb ratios (1.93–2.93), suggesting that the Heihaibei granite is an A2-type granite. The Heihaibei granite samples have zircon εHf(t) values ranging from −6.3 to −0.3, which suggests that the Early Devonian granite was derived from partial melting of Mesoproterozoic ( TDM2 = 1797–1415 Ma) crust. When considering data on contemporaneous granites, geochronological and geochemical data for the Heihaibei granite indicate that it was emplaced in a post-collisional extension environment following the closure of the Proto-Tethys Ocean. The Heihaibei granite was formed by extension of the southern subduction accretionary complex as part of the post-collisional setting during the closure of the Proto-Tethys Ocean.
Eigenfunction method for splitting of energy levels in quantum mechanics
Authors: Gnanasangeetha G.
Published: July 2022

In this work, we illustrate the use of eigenfunction method (EFM) in quantum mechanics by taking a specific example namely the splitting of energy levels under perturbation. Initially, the symmetry group of the Hamiltonian is taken to be [Formula: see text] which under the action of a perturbing potential changes to a lower symmetry namely [Formula: see text]. We have constructed an irreducible basis using the EFM for both the symmetries and show the simplifications that ensure the calculation of the expectation value of the perturbing Hamiltonian.
Investigation of transport mechanism in transient mixed convective flow of magnetize Maxwell nanofluid subject to nonuniform source/sink
Authors: Ahammad N. Ameer , Ahmed Awais , Alhowaity Awatif , Yasir Muhammad , Hamam Haneen , Galal Ahmed M.
Published: July 2022

Nowadays, the heat transfer potential of the base fluids can also be improved by adding nanoparticles to them. These nanotechnology-based fluids, called nanofluid, have superior properties such as high thermal conductivity, large critical heat flux (CHF) and improved heat transfer coefficient. The purpose of this paper is to study the thermal effectiveness of nanoparticles in transient flow of Maxwell fluid together the properties of mixed convection and magnetic field. Thermal field is controlled with the novel aspects of variable conductivity and nonuniform heat sink/source. Additionally, the impact of Brownian and thermophoretic diffusions is considered caused by nanoparticles dispersion in the fluid. The appropriate conversions yield the governing nonlinear ordinary differential system. Homotopic approach has been utilized to attain the solution of differential system and results are envisioned graphically. This study explores that the buoyancy ratio and mixed convection parameters enhance the velocity field. Further, the heat transfer rate rises significantly as the thermophoretic and Brownian diffusion parameters increase. Moreover, the effect of nonuniform heat source/sink on temperature field is noticed to be an increasing trend of temperature profile.
Some optical soliton solutions to the generalized (1 + 1)-dimensional perturbed nonlinear Schrödinger equation using two analytical approaches
Authors: Tariq Kalim U. , Seadawy Aly R. , Rizvi Syed T. R. , Javed Rizwan
Published: July 2022

In this paper, we study the perturbed nonlinear Schrödinger equation (P-NLSE) representing the propagation of waves and may be regarded as a nonlinear complicated physical model. We use the modified extended Tan hyperbolic function (METhF) approach and the [Formula: see text]-expansion approach to construct some new traveling wave structures. Several solutions have been found including dark soliton, periodic-type solitons, bell-shaped solitons, single bell-shaped solitons. We also show a graphical representation of a number of exact solutions to the dynamical model together with a description of their behavior. The proposed techniques can also be extended to various nonlinear evolution models in mathematical physics and engineering.
Review—Electrochemical Aptasensor for Pathogenic Bacteria Detection
Authors: Pham Thi-Thuy Duong , Phan Le Minh Tu , Park Juhyun , Cho Sungbo
Published: July 2022

Pathogenic bacteria are a major public cause of foodborne and waterborne infections and are currently among the most serious public health threats. Conventional diagnostic techniques for bacteria, including plate culturing, the polymerase chain reaction, and the enzyme-linked immunosorbent assay, have many limitations, such as time consumption, high rates of false results, and complex instrument requirements. Aptamer-based electrochemical biosensors for bacteria address several of these issues and are promising for bacterial detection. This review discusses the current advances in electrochemical aptasensors for pathogenic bacteria with regard to the sensing performance with various specific aptamers for different types of bacteria. The advantages and disadvantages of these electrochemical aptasensors were investigated with the aim of promoting the development and commercialization of electrochemical aptasensors for the point-of-care detection of bacteria.
A Comprehensive Review on Traffic Control Modeling for Obtaining Sustainable Objectives in a Freeway Traffic Environment
Authors: Sheikh Muhammad Sameer , Peng Yinqiao
Published: July 2022

Traffic control strategy plays a significant role in obtaining sustainable objectives because it not only improves traffic mobility but also enhances traffic management systems. It has been developed and applied by the research community in recent years and still offers various challenges and issues that may require the attention of researchers and engineers. Recent technological developments toward connected and automated vehicles are beneficial for improving traffic safety and achieving sustainable goals. There is a need to develop a survey on traffic control techniques, which could provide the recent developments in the traffic control strategy and could be useful in obtaining sustainable goals. This survey presents a comprehensive investigation of traffic control techniques by carefully reviewing existing methods from a new perspective and reviews various traffic control strategies that play an important role in achieving sustainable objectives. First, we present traffic control modeling techniques that provide a robust solution to obtain reasonable traffic and sustainable mobilities. These techniques could be helpful for enhancing the traffic flow in a freeway traffic environment. Then, we discuss traffic control strategies that could be helpful for researchers and practitioners to design a robust freeway traffic controller. Second, we present a comprehensive review of recent state-of-the-art methods on the vehicle design control strategy, which is followed by the traffic control design strategy. They aim to reduce traffic emissions and energy consumption by a vehicle. Finally, we present the open research challenges and outline some recommendations which could be beneficial for obtaining sustainable goals in traffic systems and help researchers understand various technical aspects in the deployment of traffic control systems.
Acupuncture Analgesia in Patients with Postoperative Neck Pain: A Protocol for Systematic Review and Meta-Analysis
Authors: Liu Renming , Li Songming , Liu Yuhuan , He Min , Cao Jiazhen , Sun Mengmeng , Duan Changwei , Li Tie
Published: July 2022

Background. There is a yearly increase in pain after neck surgery, which is accompanied by high consumption of opioids. However, the opioid addiction epidemic is one of the most serious public health problems worldwide. Therefore, it is important to find suitable alternatives for opioids. Acupuncture therapy has been found effective for some types of pain control. This protocol aims to evaluate the efficacy and safety of acupuncture therapy in the treatment of pain after neck surgery. Methods and Analysis. We will search eight electronic databases from their inception to April 2022. Only randomized controlled trials (RCTs) using manual acupuncture, auricular acupuncture, or electroacupuncture as major therapy will be included, regardless of whether the study was published in Chinese or English. The selection of studies and data extraction will be independently completed by at least two experienced reviewers with a master’s degree. The methodological quality of the included studies will be assessed by the Cochrane risk-of-bias tool. For the meta-analysis, Review Manager Statistical (RevMan V.5.3) software will be used. The results will be presented as the risk ratio (RR) for the binary data and the mean difference (MD) or standardized mean difference (SMD) for the continuous data. Ethics and Dissemination. This protocol for a systematic review will be submitted to a peer-reviewed journal for publication and presented at a relevant conference, and there is no need to obtain formal ethical approval. Trial Registration Number. PROSPERO registration number CRD42021281722.
Mechanical Properties of Different Lithological Rocks: A Case Study of the Coal Measure Strata in the Eastern Margin of Ordos Basin, China
Authors: Jian Xiong , Jianjun Wu , Junjie Liu , Bing Li , Xiangjun Liu , Lixi Liang
Published: July 2022

In this paper, the mechanical behaviors of different lithological rocks of coal measure strata from Shanxi Formation in the eastern margin of the Ordos Basin, China, were investigated through uniaxial compression tests, and the deformation characteristics and failure modes of different lithological rocks were investigated. On this basis, the energy evolution of different lithology rocks was also discussed. The results show that there are obvious differences in the mechanical properties of different lithology rocks in coal measure strata, resulting in different wellbore instability prevention measures and fracturing measures in different lithology strata. Under the uniaxial compression condition, the peak strain of different lithological rocks is obviously different, and the denaturation characteristics are also obviously different, and the failure modes of rocks are mainly the tensile fracture mode, suggesting that the rock samples have strong brittle characteristics. With the increase of the strain, the total energy of different lithological rocks of the coal measure strata increases, and the elastic energy first increases and then decreases rapidly, whereas the dissipated energy first increases slowly and then increases rapidly. Each energy at the peak point is different, and the average total energy of shale, silty shale, siltstone, fine sandstone, and coal is 0.022 J/cm3, 0.045 J/cm3, 0.052 J/cm3, 0.042 J/cm3, and 0.003 J/cm3, respectively, indicating that there are obvious differences in the energy evolution laws of the different lithological rocks.
Research on Indoor Environment Positioning System considering Multisensor in the Multi-Information Data Fusion
Authors: Xu Bo
Published: July 2022

Outdoor positioning can often achieve accurate positioning according to GPS and mobile phone signaling, while indoor positioning is difficult to meet the needs of practical application due to the limitations of satellite reception. In order to effectively solve the problem of large error in the individual positioning strategy in the indoor environment, this paper applies multisensor in the multisource information fusion indoor positioning system. By using the positioning results of multiple sensors to limit the range of geomagnetic matching for combined matching, the matching error can be effectively reduced. Then, the global optimal value of indoor network is calculated by using the multi-information data fusion algorithm, which can optimize the initial value and threshold of the multi-information data fusion algorithm, improve the network accuracy as much as possible, and accelerate the convergence speed at the same time. After completing the optimization processing, the indoor network can obtain the combined positioning and predicted positioning results, so as to facilitate the fusion training to the actual position coordinates, and finally obtain the optimal positioning results. The simulation results show that the mean square error predicted by the multi-information data fusion algorithm calculated by the multi-information data fusion algorithm can be effectively reduced by 76%, and the fusion positioning accuracy can be improved by 48% compared with the accuracy of a single positioning strategy. The method proposed in this paper effectively improves the positioning accuracy, indicating that the positioning performance is better.
DRDB: A Machine Learning Platform to Predict Chemical-Protein Interactions towards Diabetic Retinopathy
Authors: Wei Yu , Zhang Ruili , Li Xiaoqiang , Li Zhonglin , Guo Kaimin , Li Shanshan , Yan Li , Zhao Qian , Qu Baijian , Wang Wenjia , Zhou Shuiping , Sun He , Lin Jianping , Hu Yunhui
Published: July 2022

Diabetic retinopathy (DR), a diabetic microangiopathy caused by diabetes, affects approximately 93 million people, worldwide. However, the drugs used to treat DR have limited efficacy and the variety of side effects. This is possibly because the complicated pathogenesis of DR is associated with multiple proteins. In this work, we attempted to identify potential drugs against DR-associated proteins and predict potential targets for drugs using in silico prediction of chemical-protein interactions (CPI) based on multitarget quantitative structure-activity relationship (mt-QSAR) method. Therefore, we developed 128 binary classifiers to predict the CPI for 15 DR targets using random forest (RF),

k

-nearest neighbours (KNN), support vector machine (SVM), and neural network (NN) algorithms with MACCS, extended connectivity fingerprints (ECFP6) fingerprints, and protein descriptors. In order to facilitate discovery of the novel drugs and target identification using the 128 binary classifiers, a free web server (DRDB) was developed. Compound Danshen Dripping Pills (CDDP), composed of Salvia miltiorrhiza, Panax notoginseng, and borneol, is commonly used in the treatment of cardiovascular diseases. To explore the applicability of DRDB, the potential CPIs of CDDP in treatment of DR were investigated based on DRDB. In vitro experimental validation demonstrated that cryptotanshinone and protocatechuic acid, two key components of CDDP, are capable of targeting ICAM-1 which is one of the key target of DR. We hope that this work can facilitate development of more effective clinical strategies for the treatment of DR.
Research on Digital Industry Development Algorithm Based on Deep Learning
Authors: Gao Chao , Wu Fan
Published: July 2022

In order to explore the analysis and research on the development of digital industry and further understand the industrial development trend, in view of the continuous growth of the scale and quantity of digital industry and the continuous increase and expansion of digital industry economy, this paper uses the most popular intelligent deep learning algorithm to verify and research the efficiency of digital industry development under intelligent technology. Finally, it is considered that the application of intelligent deep learning algorithm not only meets the development needs of digital industry in the intelligent era but also improves the accuracy of economic development of digital industry and the overall development power. It has important strategic significance in promoting the economic prosperity of digital industry in the later stage, improving the advantages of industrial development and improving people’s livelihood, and has a new awareness of China’s economic development in the world.
Deficiency of kin17 Facilitates Apoptosis of Cervical Cancer Cells by Modulating Caspase 3, PARP, and Bcl-2 Family Proteins
Authors: Su Bingsen , Zhong Meifeng , Zhang Yuzhao , Wu Kunhe , Huang Qiyuan , Zhu Chuiyu , Zeng Tao
Published: July 2022

Background. The treatment of cervical cancer in the late stage is still quite challenging, because of nonspecificity in conventional therapies and the lack of molecular targeted drugs. It is necessary to find novel biomarkers for cervical cancer treatment. Methods. In the present study, cervical cell lines HeLa and SiHa with kin17 knockdown were constructed by transfection of the recombinant lentiviral vector carrying KIN17 siRNA and screened by puromycin. The established cells with kin17 knockdown were determined by fluorescence observation and western blotting. Cell apoptosis and the mitochondrial membrane potential (MMP) were detected by flow cytometry. The activity of caspase 3 enzyme was tested by spectrophotometry. The expression profile of apoptosis-associated proteins was analyzed by western blotting. Finally, we used bioinformatics and proteomic data to analyze KIN-related genes in cervical cancer. Results. The results showed high fluorescent positive rates (>90%) and high gene silencing efficiency (>65%) in HeLa and SiHa cells transfected with gene silencing vectors. Moreover, kin17 deficiency decreased the MMP and increased the apoptosis rates in HeLa and SiHa cells, respectively. Furthermore, knockdown of kin17 enhanced the activity of caspase 3 enzyme, increased the expression of cleaved PARP and Bim, while decreasing the expression of Bcl-xL and phosphorylated BAD in HeLa and SiHa cells. Identification of KIN-related prognostic genes in cervical cancer revealed that a total of 5 genes (FZR1, IMPDH1, GPKOW, XPA, and DDX39A) were constructed for this risk score, and the results showed that CTLA4 expressions were negatively correlated with the risk score. Conclusion. Our findings demonstrated that kin17 knockdown facilitates apoptosis of cervical cancer cells by targeting caspase 3, PARP, and Bcl-2 family proteins. Besides, kin17 could regulate cancer cell apoptosis through the mitochondrial pathway and could be used as a novel therapeutic target for the regulation of cell apoptosis in cervical cancer.
Evaluation of Existing Bond‐Slip Relations for CFRP‐Steel Joints and New Model for Linear and Nonlinear Adhesives
Authors: Altaee Mohammed J. , Altayee Sarmed A. S. , Kadhim Majid M. A. , Jawdhari Akram , Majdi Ali , Chabuk Ali , Al-Ansari Nadhir
Published: July 2022

Existing bond‐slip (τ‐s) relations for fibre‐reinforced polymer (FRP)‐steel joints employ different shapes and mathematical expressions, inferring that their predictions of failure load and mode, and other interface properties, might be inconsistent or inaccurate. In this study, predictions of four widely used τ‐s relations are evaluated using a large experimental database of 78 double‐lap FRP‐steel specimens. To facilitate the evaluation process, a robust finite element (FE) model is developed for each test, implementing data from either of the existing τ‐s relations to define the FRP‐steel interface. Comparisons between test and FE results indicated that the existing τ‐s models were unable of predicting the ultimate load (Pu) and effective bond length (Leff) of FRP‐steel joints, or the relation between Pu and bond length and that between Leff and FRP modulus (Ef). A new τ‐s model is developed based on an inverse FE simulation, comparison with experimental results, and regression analysis. It considers the effects of Ef, the type of FRP reinforcement (sheet or plate), and applies to both linear and nonlinear adhesives. The model predictions were validated by comparing with results from small bond tests and large FRP‐strengthened steel beams tested under bending, yielding excellent results for Pu, failure mode, and all other interfacial properties.
The Impact of the “Belt and Road” Initiative on Accounting Conservatism of Energy‐Intensive Enterprises under the Low‐Carbon Background
Authors: Liu Tingting , Gao Kai , Anwar Sajid
Published: July 2022

In recent years, the “Belt and Road” Initiative (BRI) has paid more and more attention to practicing the concept of green development. The concept of green development in the BRI will help promote the active response to climate change in the regions along the route and maintain global ecological security and is of great significance to the green transformation and development of energy‐intensive enterprises. Using company‐level data from China over the 2011–2020 period, we provide a comprehensive analysis of the impact of the BRI on energy‐intensive enterprise accounting conservatism. We find that BRI has decreased the energy‐intensive enterprise accounting conservatism, and this result continues to hold after a series of robustness tests. We also examine the effect of the RBI on accounting conservatism across company types and ages and find that the BRI is beneficial to energy‐intensive state‐owned enterprises (SOEs) and young companies. Furthermore, analysis reveals that BRI changes the accounting conservatism of energy‐intensive enterprises mainly through debt financing, tax burden, and legal environment channels.
Helicobacter suis-Associated Gastritis Mimicking Conventional H. pylori-Associated Atrophic Gastritis
Authors: Iwamuro Masaya , Murayama Somay Yamagata , Nakamura Masahiko , Hamada Kenta , Tanaka Takehiro , Okada Hiroyuki
Published: July 2022

A 45-year-old Japanese man underwent esophagogastroduodenoscopy, which revealed spotty redness at the gastric fornix, mucosal swelling, diffuse redness in the corpus, and mucosal atrophy in the gastric angle and antrum. Histological examination showed rod-shaped bacteria that appeared larger than Helicobacter pylori. The patient tested positive for rapid urease test, and serum anti-H. pylori IgG antibody test results were negative. Further examination of the bacteria revealed that H. suis antibody test was positive, and the presence of H. suis was confirmed using H. suis-specific real-time PCR. H. suis was successfully eradicated after triple therapy with vonoprazan, amoxicillin, and clarithromycin. This case reinforces the notion that non-H. pylori Helicobacter species such as H. suis and H. heilmannii may be involved in the pathogenesis of active gastritis in patients who test negative for H. pylori antibodies.
Active Control of Aerial Refueling Hose-Drogue Dynamics with the Improved Reel Take-Up System
Authors: Cheng Jiangfeng , Deng Feng , Liu Xueqiang , Ji Kang
Published: July 2022

An improved reel take-up system for suppressing the aerial refueling hose whipping phenomenon (HWP) is proposed and analyzed. The conventional spring-loaded take-up system is improved by adding a rewinding acceleration changing rate limiter (RACRL), relying on a permanent magnet synchronous motor (PMSM). The effectiveness of this new reel take-up system is confirmed by the numerical simulation at various closure speeds. The results show that the new PMSM-RACRL reel take-up system successfully accomplishes the active control of tension oscillation and the suppressing of HWP with a straightforward strategy. The amplitude of tension oscillation is reduced to one-tenth of that without active control. It is also discovered that the reel take-up speed lagging behind the drogue closure speed is mainly caused by the oscillation of hose tension, and a maximum acceleration of the reel take-up system lower than the maximum closure acceleration of the drogue will inevitably cause the slack and whipping of the hose.
Detecting Noncooperation Nodes Mechanisms in Wireless Networks: A Survey
Authors: Nobahary Solmaz , Gharaee Garakani Hossein , Khademzadeh Ahmad
Published: July 2022

Wireless networks face security problems compared with traditional wired networks. In wireless networks such as wireless sensor networks (WSNs), mobile ad hoc networks (MANETs), vehicular ad hoc networks (VANETs), and the internet of things (IoT), nodes have limited radio bandwidth and power supply then. They require cooperation in sending messages. It increases the motivation of nodes not to cooperate in such networks. This paper reviews different methods for identifying and stimulating nodes for focused cooperation. The performance of each method, its advantages, and its disadvantages have been reviewed and functionally categorized and compared with the metrics of false positive/negative rate and detection accuracy, throughput, and other metrics.
An Adaptive Sparsity Estimation KSVD Dictionary Construction Method for Compressed Sensing of Transient Signal
Authors: Ju Mingchi , Han Tailin , Yang Rongkang , Zhao Man , Liu Hong , Xu Bo , Liu Xuan
Published: July 2022

Overcomplete dictionaries occupy an essential position in the sparse representation of signals. The dictionary construction method typically represented by

K

singular value decomposition (KSVD) is widely used because of its concise and efficient features. In this paper, based on the background of transient signal detection, an adaptive sparse estimation KSVD (ASE-KSVD) dictionary training method is proposed to solve the redundant iteration problem caused by fixed sparsity in existing KSVD dictionary construction. The algorithm features an adaptive sparsity estimation strategy in the sparse coding stage, which adjusts the number of iterations required for dictionary training based on the pre-estimation of the sample signal characteristics. The aim is to decrease the number of solutions of the underdetermined system of equations, reduce the overfitting error under the finite sparsity condition, and improve overall training efficiency. We compare four similar algorithms under the speech signal and actual shock wave sensor network data conditions, respectively. The results show that the proposed algorithm has obvious performance advantages and can be applied to real-life scenarios.
An Approach for Performance Assessment of Tracked Vehicle Transmission Based on the Median-Rank Weight and the Least-Square Support Vector Machine
Authors: Zou Tiangang , Zhang Jinbao , Yan Qingdong , Wei Ran , An Yuanyuan
Published: July 2022

Transmission efficiency is one of the important indicators for the performance assessment of the tracked vehicle transmission device. Considering the influence of many factors in the transmission process at the straight driving mode, an approach for constructing the normalized comprehensive performance assessment indicator is proposed based on the median rank of no-load power loss and the median rank of transmission efficiency. Then, the performance assessment of the single tracked vehicle transmission device is performed with the least-square support vector machine (LSSVM). The results show that the stable comprehensive performance assessment indicator could be obtained in the first 10 speed measurement points, and the performance state of the vehicle transmission device is identified according to the criterion.
Multiobjective Optimization Designs in Downlink NOMA Transmission Systems
Authors: Li Zhe
Published: July 2022

To further balance the high-capacity transmission requirement and the scarce spectrum resources status quo, we investigate the joint optimization of energy efficiency (EE) and spectral efficiency (SE) in a downlink multiuser NOMA system. While ensuring the user quality of service (QoS), a power allocation algorithm based on two-layer optimization is proposed by transforming the original multiobjective optimization problem into a univariate problem through the linear weighted sum method. Based on the optimal user power allocation coefficient solution obtained from the inner layer, the outer layer applies the bisection principle to search for the optimal system transmit power according to the uniqueness of the maximum value of pseudo-concave functions. Simulation results show that the proposed algorithm always converges within fewer iterations and can achieve the flexible tradeoff between EE and SE. This is of great significance for improving the energy utilization of actual scenarios with time-varying communication demands.