bluuebunny/crossref_metadata_2025 huggingface dataset:
Destructive Effects of Steroidal Drug Abuse and their Immunological Impact
Authors: Duraisamy Parimalanandhini , Ravi Sangeetha , Krishnan Mahalakshmi , Catherene Martin Livya , Manikandan Beulaja , Janarthanan Sundaram , Manikandan Ramar
Published: July 2023

Steroidal drugs are synthetic in nature that are closely identical to naturally
produced hormones in our body such as cortisol and testosterone. They are lifesavers
for several threatening medical conditions. They are currently in wide use for the
treatment of various inflammatory diseases since they are known to involve in
suppressing the immune system resulting in a reduced inflammatory process. They are
produced in different forms and do not cause any major side effects when consumed at
low doses. However, occasionally they lead to perilous side effects when taken in
appropriate doses that lead to mental health problems, high blood pressure, diabetes,
osteoporosis, etc. Practices such as the uptake of illicit anabolic steroids and
corticosteroid drugs without an appropriate prescription can potentially lead to fatal
side effects. Anabolic steroids are performance and image-enhancing drugs that were
once viewed as predicament associated with bodybuilders and have now become a
widespread problem throughout our society including children. Dietary supplements
which act as steroidal precursors also promote medical consequences that are similar to
steroids and the absence of such awareness in our society leads to varied difficulties in
our current lifestyle. The increasing concern about possible health hazards in
association with abusive steroid drug uptake should be addressed with strict measures.
It is important to educate our society about the hazardous effects of steroidal drug
abuse and the precautions that need to be carried out while using them. This chapter
highlights different types of steroid drugs that are currently in use and the deleterious
side effects caused by their abusive use. Potential treatments for their withdrawal and
preventive measures will also be addressed in detail.
Изотопический сдвиг ИК полос поглощения монокристаллов германия
Authors: Кропотов Г.И. , Рогалин В.Е. , Каплунов И.А. , Шахмин А.А. , Филин С.А. , Буланов А.Д.
Published: July 2023

A clear correspondence between the position of the peak in the IR absorption spectrum of isotopically pure germanium single crystals and the mass number of the isotope was found. The dependence obtained can be used for express analysis of the mass composition of isotopically pure germanium single crystals.
Reach, Adoption and Sustainability of a Mobile Clinical Decision Support Tool Paired with a National Quality Improvement Project Targeting Emergency Department Febrile Infant Management (Preprint)
Authors: Kerns Ellen , McCulloh Russell , Dai Hongying
Published: July 2023

BACKGROUND

Deploying electronic clinical decision support (ECDS) using a mobile app (mECDS) has shown the potential to be a viable method of overcoming scalability and sustainability limitations.

OBJECTIVE

We aimed to determine, during and post an associated project, whether mECDS tool use (1) increased over time, 2) spread to other areas, 3) differed between aress with and without project sites, 4) was associated with other corresponding geospatial and temporal factors.

METHODS

In 2016, our team released a free mECDS as part of a national multi-site project. For this study, we evaluated trends in weekly mECDS use: 1) metric related screen views (MetricHits), 2) unique designated market areas (DMA) where the mECDS was used (UniqueDMAs), 3) density of use or MetricHits/UniqueDMAs (HitsPerDMA). Linear regressions were performed for each use measure across three time periods (during the project, 1-year post, 2-years post). Models were alo stratified by DMA site status.

RESULTS

Strong growth in the number of UniqueDMAs and MetricHits occurred during the period of 1-year post and continued to be stable 2-years post. HitsPerDMA had stronger growth in DMAs with a site. MetricHits were higher in DMAs with a larger population, more sites, more children’s hospitals, and in the summer versus winter months.

CONCLUSIONS

Sustained temporal and geospatial increases in mECDS app usage were found contrary to more rapid drop offs in post-project ECDS usage found by others. Further research is needed to determine the factors driving mECDS use and its impact on clinical practice and patient outcomes.
Moderating Effect of Media Literacy and Flow Between Web-based Learning Environment and Knowledge Sharing among Chinese Medical Students (Preprint)
Authors: Wang Guan-jun , Li Shu-hui , Guo Hai-chen , Yuan Jia , Wang Yan-ping , Gan Yu-tian , Zhang Yi-lin , Zhao Ji-yang , Zhang Zhong , Zhang Shu-E , Yang Li-bin
Published: July 2023

BACKGROUND

The Internet era provides new opportunities for knowledge transfer between individuals, which helps medical students efficiently learn medical knowledge and skills.

OBJECTIVE

This study aims to (1) assess the status of knowledge sharing among Chinese medical students; (2) examine the association between web-based learning environment, media literacy, flow, and knowledge sharing; (3) identify the moderating role of media literacy and flow in the relationship between web-based learning environment and knowledge sharing.

METHODS

The study was conducted online from July to September 2021 in China. A total of 987 valid responses were retained (response rates was 82.25%). Hierarchical linear regression analysis was used to explore factors related to knowledge sharing and test the moderating effect of flow and media literacy on the association of web-based learning environment and knowledge sharing.

RESULTS

The mean score of knowledge sharing among Chinese medical students was 3.91 ± 0.58. Knowledge sharing was significantly and positively influenced by the web-based learning environment (β =.159, P < .001), flow (β =.480, P < .001) and media literacy (β = .366, P < .001). Flow (β =.732, P < .001) and media literacy (β = .900, P < .05) significantly moderated the association between web-based learning environment and knowledge sharing.

CONCLUSIONS

The positive correlation between web-based learning environment and knowledge sharing is more pronounced among medical students with high flow or high media literacy. Our finding provides a more optimal pathway for promoting knowledge sharing in Chinese medical education settings, including strengthening network infrastructure construction, creating a harmonious web-based learning environment, and integrating media literacy into the curriculum.
The relation analysis between principal's leadership behavior style and teachers' school commitment
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Tae-Sang
Published: July 2023

The purpose of this study is to analyze the relationship between principal's leadership behavior style and teachers' school commitment among 3 areas school teachers. The questionnaire were distributed to 173 school teachers in Gyunggi, Daejeon, Gangwon Province.
It were found that the high different perception existed on principal's leadership behavior style and teachers' school commitment by sex, school size, school location, and teaching experience. And there was a significant correlation between principal's leadership behavior style and teachers' school commitment factors. In addition, it was found that there were significant relationships among some subvariables of principal's leadership behavior style and teachers' school commitment.
Experience of Alternative Practice Education for Trainees in Nursing Care Training Course : Exploration Using Q methodology
Authors:   Korean Academy of Integrated Care Management, Lee Yu-JIN , Hwang Mi-Kung
Published: July 2023

The purpose of this study was to improve the educational process to strengthen the professionalism of caregivers known to play a key role in the long-term care service system for the elderly. Therefore, in the process of fostering nursing care workers, characteristics of perceptions of those who experienced alternative practice were identified, typified, and explored through the Q methodology to confirm the meaning. In order to form the Q population, four study participants were interviewed in advance. Q samples on a total of 34 trainees' alternative practice education experiences were extracted through interview content and literature analysis. Q classification was conducted for 22 study participants. P samples were male and female trainees educated at the caregiver training center, 22 caregiver trainees with nursing assistant and social worker licenses corresponding to long-term care workers, and caregiver trainees corresponding to the general new class. Three recognition factors extracted by analyzing the data collected in Q sorting with the PC QUANL program explained 40.6% of the total variance. They were ‘rational inquiry’, ‘critical analysis’, and ‘realistic satisfaction’. According to implications of research results, this study proposes that it is important to improve the curriculum that can strengthen the professional competency of caregivers who respond to the era of integrated care in the community.
Experiences of Caring for Others and Self-Care Among Care Workers Serving the Vulnerable Population
Authors:   Korean Academy of Integrated Care Management, Seon Mi Jeong
Published: July 2023

As the demand for social care increases, the topic of good care continues to be discussed. The purpose of this study was to provide a contextual direction for good care by exploring in-depth experiences of caring for others and self-care among care workers serving the vulnerable population. To achieve this, five carers from a vulnerable class were recruited through intentional and snowball sampling. Qualitative research was conducted through in-depth interviews. Within case and between case analysis methods were used. As a result of this study, experiences of caring for others and self-care among vulnerable care workers resembled a symphony of fate, including major and minor keys and repetition. Care for others and self-care revealed six sub-elements (expectations of caregiving, satisfaction of caregiving, limitations of caregiving, vulnerability in self-care, burnout in self-care, and realignment of self-care) and a total of 26 units of meaning. The central theme was ‘transition and repetition toward the balance of good care (harmony).’ Finally, based on findings in this study, social welfare practices and policies are suggested.
Ewolucja miejsca i roli rzepaku w rolnictwie oraz gospodarce Polski
Authors: Kapusta Franciszek
Published: July 2023

Rzepak jest znany w uprawie od ok. 4 tys. lat, a obecnie następuje natężenie jego uprawy na cele spożywcze i przemysłowe. Celem opracowania było ukazanie znaczenia rzepaku w rolnictwie i gospodarce. Zbadano: poziom i strukturę spożycia tłuszczów w Polsce w latach 1965-2013, powierzchnię uprawy, zbiory i plony roślin oleistych oraz rzepaku w latach 2000-2013, bilans handlu zagranicznego surowcami i produktami roślin oleistych w latach 2007-2013, bilans nasion rzepaku i samowystarczalność Polski w latach 2000/2001-2012/2013. Opracowanie powstało w oparciu o publikacje zwarte i ciągłe, informacje GUS oraz raporty IERiGŻ. Zgromadzony materiał został opracowany za pomocą metod: porównawczej w formie horyzontalnej i wertykalnej, statystycznej, a ocenę samowystarczalności dokonano metodą Kapusty. Badania wykazały dynamiczny rozwój produkcji rzepaku na początku XXI w., powodowany zapotrzebowaniem na jego nasiona na cele spożywcze i przemysłowe – głównie do produkcji biopaliw.
Changes in the Value of Exports of Agricultural Products from Selected ACP Countries
Authors: Chryniewicz Łukasz
Published: July 2023

The process of globalization creates and stimulates the network of mutual economic and trade relations between countries through cooperation within international organizations. Export of agricultural products has a measurable and significant impact on the development of world trade, and therefore it is important to examine the changes that have occurred in exports of selected ACP countries from 2002 to 2013.
Regional Diversification of Expenditure Structure in Poland: a GCA Approach
Authors: Gostkowski Michał , Jałowiecki Piotr , Tekień Agnieszka
Published: July 2023

The paper presents the results of the analysis of household expenditure structures in Poland using Grade Correspondence Analysis (GCA). Studies have shown that in the analyzed period the structure of consumer expenditure changed. The share of food and non-alcoholic beverages expenditures decreased steadily, while the share of expenses related to maintenance and household equipment, culture and recreation, or restaurants and hotels steadily increased. Further studies have shown that the structure of consumer expenditures in Poland is diversified regionally. The greatest variation occurs between the north-eastern region voivodeships and the central region/south-west voivodeships.
The Impact of College English Teaching on Improving Students’ Writing Effectiveness in the Context of Big Data
Authors: Sun Lu
Published: July 2023

In order to improve the English writing ability of college students and help them lay a good foundation for written communication in English when they graduate from school or continue their studies abroad. This paper collects data on college students’ English writing on the Internet through a clustering algorithm with the support of big data technology background and defines the scoring criteria for essays to target the deficiencies in college students’ English writing nowadays and urge students to correct them. With the support of a search algorithm, we obtained the demand for college students’ English from employers in China over the past 10 years and reflected on the aggregated demand data to link classroom teaching with workplace English. The study found that the English language skills valued by employers in order were speaking 80.5%, writing 86.3%, reading 57.9%, listening 40.2%, and translation 21.7%. A demand questionnaire survey was conducted randomly among non-English majored first- to fourth-year undergraduate students in five universities with tiered teaching. The results showed that 72% of the students thought they needed to improve their English speaking skills, 70.3% thought they needed to improve their English writing skills, and 40% thought they needed to improve their grammar skills, which shows that college students’ needs for improving their English speaking and writing skills are particularly prominent. The emphasis on English writing classroom education for college students can solve the urgent needs of students for English learning and improve college students’ English writing skills through big data science.
Construction of a refined people management model for SMEs based on discrete regression algorithm
Authors: Ma Hongli
Published: July 2023

Management innovation is particularly important today when technological convergence is becoming increasingly evident. Furthermore, as employees are the most important resource in work dynamic scheduling, the mobility of employees will bring extremely discrete regression particle swarm algorithm uncertainty to work projects, making its scheduling problem more complex. This paper first proposes to apply a discrete regression particle swarm algorithm based on refinement management as an enterprise management innovation to optimize three indicators of time, cost, and stability by implementing refinement personnel management. Secondly, we set constraints for dynamic tasks to implement management rescheduling to avoid overworking employees and thus maximize profits for the enterprise. Finally, the effectiveness of the discrete regression particle swarm algorithm is verified by selecting 27 benchmark examples to compare from three indicators of contribution and time and cost. The results show that the discrete regression particle swarm algorithm (S-PSO-VNS) has an average time reduction of 22.65%, a cost reduction of 15.21%, and a stability improvement of 35.74% compared to the other two control algorithms in terms of management algorithm quality and performance analysis. The research data illustrates that the discrete regression algorithm proposed in this paper can have high efficiency and effectiveness, and the discrete regression particle swarm algorithm can provide managers of SMEs with more informed decisions on work schedules, thus maximizing profits and achieving more profitability.
Research on the evaluation of the employment effect of Jiangsu artificial intelligence based on neural network on colleges and universities
Authors: Hao Fujin
Published: July 2023

Under the wave of digitization of big data information, the development of artificial intelligence technology continues to deepen the information technology revolution, which has a profound impact on human society and will also revolutionize the employment of different industries and groups. In this paper, we study the evaluation of employment effects of universities based on the neural network Jiangsu artificial intelligence. Since a neural network model needs to be built for training and there is a certain requirement for sample size, Jiangsu AI is selected for the study on the evaluation of employment effects in colleges and universities. The results show that the Dense Net model (C2) has better overall performance than the Vgg Net model, with weight and efficiency values of 89 and 88%, respectively, under the index of the educational level of college employment. Analyzing the impact of AI on college employment and unemployment in Jiangsu for the eight years from 2015 to 2022, it is concluded that with the development of time, the employment rate of college graduates reaches 87%, and the unemployment rate is 13% in 2022. This study has a guiding value for the employment of college graduates, and colleges and universities should focus on the future talent demand, guide students to cope with the possible impact of AI technology actively, cultivate students to acquire core competencies and literacy that AI does not easily replace, and promote high-quality employment of college students.
A study of cultural differences in Sino-Thai translation based on big data analysis
Authors: Zhao Jin
Published: July 2023

In today’s era of digital development of big data information, cross-cultural and cross-regional communication are becoming more and more frequent, and human beings have the right and desire to enjoy certain common cultural information, and it has been 38 years since China and Thailand established diplomatic relations in 1975. Cultural differences in Sino-Thai translation based on big data are studied in four aspects: inter-translation of personal names, inter-translation of geographical names, inter-translation of quantity sets, and inter-translation of date and time. This paper focuses on the research of cultural differences in Sino-Thai mutual translation based on big data analysis, constructing a bilingual word translation model with monolingual word vectors under the big data platform Spark, and conducting data analysis on the accuracy and efficiency of translation by collecting Chinese dataset and Thai dataset in parallelization algorithm in two structures SchemeA and SchemeB . The results show that the accuracy of the bilingual word vectors generated by either SchemeA or SchemeB improves as the size of the dataset increases. In addition, SchemeA is better than SchemeB in terms of accuracy and SchemeB is better than SchemeA in terms of efficiency performance, so Sche A me is suitable for translation tasks with high accuracy requirements, while Sche B me is suitable for translation tasks on large data sets. This study can improve the efficiency and accuracy of mutual translation between China and Thailand and train more translators. Today’s high technology brings much convenience to people, and social knowledge is constantly updated and developed. It is necessary to study in order to keep up with the changes of the times and to grasp the updates of the words of the times in order to translate well and more accurately, and this study not only contributes to the translation work in China but also has an important historical significance to the cultural exchange and communication between China and Thailand.
Associação entre carboidratos, triglicerídeos e doenças cardiovasculares
Authors: Avelar Nikolly Fabiana Dias de , Machado Patrícia da Cunha , Azevedo Filho Francino Machado de , Reis Lilian Barros de Sousa Moreira
Published: July 2023

Objetivo: Avaliar o papel dos carboidratos dietéticos nas doenças cardiovasculares e no marcador lipídico triglicerídeo e qual o seu impacto nos desfechos cardiovasculares. Métodos: Revisão integrativa da literatura, com busca nas bases de dados PubMed e Biblioteca Virtual em Saúde (BVS), no intervalo de tempo de 2012 a 2022, por meio dos Descritores em Ciências da Saúde (DeCS) e Medical Subject Headings (Mesh): triglycerides, carbohydrates e cardiovascular risk factors com o operador booleano “AND”. Utilizou-se como pergunta norteadora: Qual a influência dos carboidratos dietéticos no marcador triglicerídeo e qual sua relação com doença cardiovascular? Resultados: Foram incluídos nessa análise 10 artigos que atenderam aos critérios de inclusão. Ao todo, entre os estudos incluídos na revisão, foi obtida uma amostra de 17,879 indivíduos com idades entre 18 e 75 anos. O IMC médio variou entre 23 e 45 kg/m². Considerações finais: Dietas com baixo teor de carboidratos podem ser eficazes para perda de peso e promovem benefícios nos marcadores de risco cardiovascular a curto prazo, com um aumento nos níveis de HDL. No entanto, quando se trata de triglicerídeos, os resultados são controversos.
Management Style SMEs Development of Wooden Batik Centre
Authors: Torrido Aryan
Published: July 2023

Industrial centers are often used as places for small and medium enterprise (SMEs) development activities and sources of regional income. This includes wooden batik centers in the DIY Province, namely in Putat Village, Gunung Kidul Regency, and Sendangsari Village, Bantul Regency. However, the development activities of SMEs in industrial centers in Indonesia were not optimal, one of the reasons is the management strategy. Therefore, this article contains a comparative study of management styles of development activities, using qualitative research methods, with multiple cases.  The results showed that there was a different management style of SMEs development activities in the wooden batik center, where the management style of the wooden batik center SMEs development activity in Putat Village which was applied by the management of Kopinkra Sumber Rejeki Makmur as a center development institution was authoritarian, so the management system tends to be closed. In contrast to the management style of SMEs development activities in the wooden batik center in Sendangsari Village, which is applied by the Sido Katon Cooperative management as a development center institution assisted by the Pokdarwis Institute and BPDW Krebet Binangun, it is democratic, so the management system tends to be open.
Development of Innovation Capability Model: Analysis of e-CRM and Risk Perceptions of Covid-19 in Bogor City MSMEs
Authors: Chandra Yanita Ella Nilla , Barry Husnil
Published: July 2023

The phenomenon of the commercial revolution 4.0 encourages MSME actors to comply with current trends in order that the goods produced may be competitive. Creative enterprise merchandise require innovation competencies with a view to produce advanced merchandise. This study  takes a look at discusses improvement troubles withinside the MSME quarter that are despite the fact that restricted in conventional organization control, inadequate fine of human assets, manufacturing scale and strategies, low innovation functionality and confined get admission to to economic establishments, especially banking. The growth the variety of enterprise actors primarily based totally on facts from the Cooperatives Office the town of Bogor in 2021 with a mean growth of 6.141% of all forms of organizations isn't always matched with the aid of using trends the subject of innovation to assist enhance the advertising overall performance of SMEs the town of Bogor. Where in enhancing the capacity of innovation, it's miles anticipated to synergize with Customer Relationship Marketing or CRM such as numerous information, consumer involvement, long-time period partnerships and technology-primarily based totally trouble fixing in developing enterprise overall performance.
Factors Affecting Behavioral Intention of Millennial Generation Using Mobile Delivery Order Services in Digital Era Revolution
Authors: Mavilinda Hera Febria , Putri Yulia Hamdaini , Nazaruddin Akhmad
Published: July 2023

The purpose of this research is to analyze the factors that can influence the behavioral intention of the millennial generation towards the use of mobile delivery order (MDO) in food delivery services. Questionnaires were distributed to 218 respondents who are millennials and have used the mobile delivery order services. The sampling technique uses non-probability   random sampling methods. This research is a quantitative research that using Structural Equation Modeling (SEM) analysis which is operated by Analysis of Moment Structure (AMOS) program. The results showed that the variables of perceived usefulness, time saving orientation and non-pharmaceutical intervention are factors that can influence the behavioral intention of the millennial generation for using MDO in food delivery services. Meanwhile, the perceived ease of use has no significant effect on the behavioral intention of the millennial generation for using MDO.
Assessment of Duration and Frequency of Drought by Percent Normal Precipitation Index (PNPI) for Lombok Island
Authors: Saidah Humairo , Budianto Muh. Bagus , Yasa I Wayan , Hidayat Syamsul , Jaya Negara I Dewa Gede , Sulistiyono Heri
Published: July 2023

Meteorological drought is a climatic condition categorized by a scarcity of rainfall. Understanding the drought characteristics is a significant step appointed uncertain climate conditions due to current global climate change. This study aims to assess the duration and frequency of drought using the Normal Precipitation Index (PNPI) method to identify drought characteristics in the study area. The PNPI revealed a spatial variation in percent value monthly rainfall to average rainfall across the island of Lombok that prolonged and severe droughts have occurred in entire study areas with varying duration and frequency. PNPI method in analyzing drought events in the island of Lombok showed that Sopak is the driest area and Sekotong is the wettest one
CCL14 is differentially expressed in central nervous system metastasis.
Authors: Mamoor Shahan
Published: July 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer and lung cancer (1-3). We mined published RNA-sequencing and multiplexed gene expression data (4, 5), comparing primary and brain metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the CNS. We found that C-C motif chemokine ligand 14, encoded by CCL14, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Multiplexed gene expression data (5) revealed conserved differential expression of CCL14 in CNS metastasis in patients with lung cancer. CCL14 mRNA was present at increased quantities in metastasis to the brain in humans with breast cancer. Expression of CCL14 in primary tumors of the breast was correlated with overall, distant metastasis-free, and recurrence-free survival. Modulation of CCL14 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with cancer of the lung and breast.
Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension
Authors: SUNGUR Mustafa Azmi , SUNGUR Aylin , CAN Fatma , ESEN Aycan , GÜNGÖR Barış , YILDIRIMTÜRK Özlem
Published: July 2023

Abstract

Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long-term mortality in PAH.

Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months.

Results: 92 patients (mean age=43.915.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score (2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p
Increase of the motility of buck semen with Andromed® extender and the addition of HTF
Authors: Quintero-Elisea Juan A. , Clemente-Sánchez Fernando , Cortez-Romero César , Velázquez-Morales José V. , Olguín-Arredondo Héctor A. , Orozco-Lucero Ernesto
Published: July 2023

Objective: To test whether HTF (Human Tubal Fluid) is capable of protecting goat sperm cells increasing the semen m
Objective: To determine if HTF (Human Tubal Fluid) can protect buck sperm cells, increasing semen motility when used by itself or combined with the Andromed® commercial extender.
Design/Methodology/Approach: The semen of eight bucks of the Boer breed was used (10 ejaculates per male). Each ejaculate was diluted in three treatments (5 repetitions per treatment): 1) only Andromed®; 2) only HTF; and 3) Andromed® + HTF. The following variables were evaluated: mass motility (MM) and progressive motility (MP) in fresh (37 °C) and refrigerated (5 °C) semen. The differences between treatments were detected, based on the MM and MP in fresh and refrigerated semen variables, using the GLM procedure (SAS V9). In the case of the MM evaluated in three different periods, the measures repeated over time were analyzed using the Proc Mixed procedure (SAS V9).
Results: Regarding the quality of fresh spermatozoa, MM and MP recorded similar values (p>0.05) for the three treatments. On the one hand, MM registered 97.1% for Andromed®, 95.8% for HTF, and 97.5% for Andromed® + HTF; its highest value was achieved with the Andromed® + HTF combination, followed by Andromed® and HTF. On the other hand, the highest MP percentage was observed with the combination of Andromed® + HTF (91.0%), followed by Andromed® (90.4%), and HTF (89.0%). Regarding the quality of the sperm refrigerated at 5 °C, the combination of Andromed® + HTF had a higher MP value (p<0.05) than other treatments.
Study Limitations/Implications: In all the evaluated treatments, the motility of sperm decreased over time (0 to 24 hours after cooling); however, the treatments with Andromed®, and Andromed®+HTF maintained a high motility.
Findings/Conclusions: The combination of Andromed® and HTF can be used to dilute both fresh and cooled semen.
Types and Nature of Oral Feedback Given by Teachers on Students’ Speech
Authors: Lemma Befikadu
Published: July 2023

Classroom oral feedback helps students to improve their English language performance. The purpose of this study is to examine English language teachers' attitudes toward different types and methods of providing feedback on students' speech during English classes. To achieve this objective, eight speaking lessons for tenth-grade students at Mieraf Primary and secondary school were recorded. Transcriptions were made from these recorded lessons, specifically focusing on classroom exchanges involving teacher initiation, learners' responses, and teacher feedback. The feedback types utilized in the recorded lessons were based on the models proposed by Zahorik (1970) and Chaudron (1977). Furthermore, the frequency of each feedback type found in the recorded lessons was determined and analyzed. In addition to the transcriptions and analysis, questionnaires were administered to four English teachers who taught in the five sections. These teachers were also interviewed to gather their perspectives. The data collected from the questionnaires and interviews were analyzed both quantitatively and qualitatively. The findings revealed that the teachers frequently employed the elaborate praise type of feedback. Moreover, the majority of students expressed positive attitudes toward the feedback they received from their teachers regarding their speech. However, it was noted that a significant number of students expressed the need for feedback from their peers, but only if their teachers provided guidance on how to provide constructive comments to one another. Based on the results, it is recommended that students should be informed about the role of peer feedback in improving their speech. Additionally, teachers should create opportunities for students to enhance their speech skills independently and encourage them to receive feedback from their peers.
Maternal complete heart block in pregnancy: a case report, literature review and management options
Authors:   Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Rutgers University, NJ, USA, Kaila Krishnamoorthy , Powell Kim ,   Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Rutgers University, NJ, USA, Williams Shauna ,   Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Rutgers University, NJ, USA, Gittens-Williams Lisa ,   Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Rutgers University, NJ, USA, Apuzzio Joseph ,   Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Rutgers University, NJ, USA
Published: July 2023

Objective: to discuss the management of maternal complete heart block during pregnancy Methods: This is a case report, discussion, and recommendations for managing complete heart block during pregnancy. Results: Maternal complete heart block was managed successfully during pregnancy. Conclusion: Maternal complete heart block occurring during pregnancy is a rare condition that can first present during pregnancy. Management is guided by expert opinion based on sparse literature, with no established guidelines, and requires a multidisciplinary team approach.
COVID-19 Preoperative Blood Tests : What Do They Tell Us About COVID-19 Vaccines?
Authors:   Department of Plastic Surgery, 74 avenue Jean Jaures 47200 Marmande, France., Dupoirieux Laurent
Published: July 2023

This observational real-world study was conducted on 14 patients who needed a minor office surgery or procedure and who were eligible for a COVID-19 booster according to the French Health Agency. The aim of the study was focused on biological markers which might have an incidence after surgery. The platelet count, D-dimer level, and anti-spike IgG antibodies levels, were the numeric parameters studied. The study showed no perturbation in the platelet count. Conversely, we observed an abnormal elevation of D-dimer levels in 4 patients (28 %). The most remarkable data was the constant residual positive level anti-spike IgG antibodies observed in all patients after 6 months ranging from 44 to 5680 BAU/mL. For these reasons, further studies on a bigger cohort would be useful to clarify the possible incidence of COVID-19 vaccines on D-dimer levels and a monitoring of the immune response should be proposed to all patients eligible for a SARS-CoV-2 vaccine booster in order to evaluate the benefit-risk ratio of this injection.
The Role of Mirror Neuron System (MNS) in Autism Spectrum Disorders (ASD)
Authors:   Faculty of Psychology, Isfahan University, Isfahan, Iran, Nabizadeh Mohammad
Published: July 2023

The Mirror Neuron System (MNS) is a group of specialized neurons that discharge when an individual performs an action or observes another individual performing the same activity. This system is divided into two principal hubs; the premotor area in the frontal lobe and inferior parietal lobule(IPL). Mirror neurons play an essential role fundamentally in human social interaction, such as action observation, imitation, understanding the emotions of others, and a myriad of other sophisticated human behavior and thought processes as well as the theory of mind. Since people with Autism Spectrum Disorders (ASD) have disorders and defects in communication, social interaction, the theory of mind, etc . So it can be suggested that defects in the mirror neuron system (MNS) may be linked to disorders like ASD and also play an essential role in this phenomenon. In this review, we discuss this connection.
Bacterial and prognostic profile of nosocomial meningitis in newborns
Authors:   Neonatal Intensive Care Unit, Mother and child Pole, Mohammed VI University Hospital, Marrakesh, Morocco, Elhanafi FZ ,   Child Health and Development Research Laboratory, faculty of medicine, Cadi Ayyad University, Marrakesh, Morocco, Bennaoui F , Mahir N , Slitine NE , FMR Maoulainine
Published: July 2023

Introduction: Nosocomial neonatal meningitis is particularly dreadful because it occurs in patients of immature immunity and a developing brain. It is always a challenge for the clinician due to its clinical polymorphism making the diagnosis often difficult Aim: To study the epidemiological, clinical, bacteriological, therapeutic and evolutionary aspects of neonatal nosocomial bacterial meningitis. Results: Through our series, we reported fourteen cases of nosocomial meningitis, ie 43% of meningitis recorded over the study period. A male predominance was observed in 57.1%. The newborns were preterm in 28% of cases and had low birth weight in 42% of cases. The germ isolated was Klebsiella pneumoniae in 28.4% of cases. The blood culture was positive in 64% of cases. The same germ was isolated in both blood and the cerebrospinal fluid in 42% of cases. The complications found were: ventriculitis (28.5%), triventricular and tetraventricular hydrocephalus (14.2%) and multiple cerebral abscesses (14.2%). The mortality rate recorded in our series was 28.5%. Conclusion: Nosocomial meningitis is a serious or even fatal condition requiring early diagnosis and adequate antimacrobial therapy. Prevention remains the best strategy for the battle against this infection
Clinical Diagnosis of Pleuroparenchymal Fibroelastosis
Authors:   Professor, M.D, Department of Pulmonary Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University, Istanbul, Turkey, Tetikkurt Cuneyt
Published: July 2023

Pleuroparenchymal fibroelastosis (PPFE) is an extremely rare interstitial lung disease (ILD) characterised by fibroelastotic changes predominating in the subpleural lung parenchyma with visceral pleural fibrosis involving the upper lobes. It has distinctive clinical, radiological, and pathological manifestations. Diagnosis constitutes literally a stalemate because of its rarity, unavailability of an agreed diagnostic consensus, and requirement of tissue biopsy for an accurate final diagnosis that can not be performed in most of the patients owing to the comorbid complications of the disease itself. Identification of PPFE may also pose great difficulties due to the coexistence of other interstitial lung diseases. PPFE usually exhibits a persistently deteriorating prognostic course culminating in fatal complications including respiratory failure, pulmonary hypertension, cor pulmonale, or pneumothorax. Presence of disease relevant complications frequently preclude invasive tissue biopsy interventions in these patients leading to a diagnostic challenge for clinicians. This review aims to provide a definitive diagnosis based on entirely the clinical manifestatins of PPFE by shedding light on the pathogenesis, clinical, and radiologic findings of the disease. Histopathological tissue evaluation was also included in the diagnostic approach for patients whose condition was suitable for an invasive biopsy intervention. With this review, it is concluded that an approach consisting of exclusively clinical manifestations will ensure adequate support for an accurate PPFE diagnosis without any requirement for histopathological tissue examination.
Motor cortex hemodynamic response to goal-oriented and non-goal-oriented tasks in healthy subjects
Authors: Lacerenza Michele , Frabasile Lorenzo , Buttafava Mauro , Spinelli Lorenzo , Bassani Elisa , Micheloni Francesco , Amendola Caterina , Torricelli Alessandro , Contini Davide
Published: July 2023

Background

Motor disorders are one of the world’s major scourges, and neuromotor rehabilitation is paramount for prevention and monitoring plans. In this scenario, exercises and motor tasks to be performed by patients are crucial to follow and assess treatments’ progression and efficacy. Nowadays, in clinical environments, quantitative assessment of motor cortex activities during task execution is rare, due to the bulkiness of instrumentation and the need for immobility during measurements [e.g., functional magnetic resonance imaging (MRI)]. Functional near-infrared spectroscopy (fNIRS) can contribute to a better understanding of how neuromotor processes work by measuring motor cortex activity non-invasively in freely moving subjects.

Aim

Exploit fNIRS to measure functional activation of the motor cortex area during arm-raising actions.

Design

All subjects performed three different upper limbs motor tasks: arm raising (non-goal-oriented), arm raising and grasping (goal oriented), and assisted arm raising (passive task). Each task was repeated ten times. The block design for each task was divided into 5 seconds of baseline, 5 seconds of activity, and 15 seconds of recovery.

Population

Sixteen healthy subjects (11 males and 5 females) with an average (+/− standard deviation) of 37.9 (+/− 13.0) years old.

Methods

Cerebral hemodynamic responses have been recorded in two locations, motor cortex (activation area) and prefrontal cortex (control location) exploiting commercial time-domain fNIRS devices. Haemodynamic signals were analyzed, separating the brain cortex hemodynamic response from extracerebral hemodynamic variations.

Results

The hemodynamic response was recorded in the cortical motor area for goal-oriented and not-goaloriented tasks, while no response was noticed in the control location (prefrontal cortex position).

Conclusions

This study provides a basis for canonical upper limb motor cortex activations that can be potentially compared to pathological cerebral responses in patients. It also highlights the potential use of TD-fNIRS to study goal-oriented versus non-goaloriented motor tasks. Impact: the findings of this study may have implications for clinical rehabilitation by providing a better understanding of the neural mechanisms underlying goal-oriented versus non-goal-oriented motor tasks. This may lead to more effective rehabilitation strategies for individuals with motor disorders and a more effective diagnosis of motor dysfunction supported by objective and quantitative neurophysiological readings.
Integrative analysis illustrates the role of PCDH7 in lung cancer development, cisplatin resistance, and immunotherapy resistance: an underlying target
Authors: Li Huakang , Xu Haoran , Guo Hong , Du Kangming , Chen Diang
Published: July 2023

Background: Cisplatin resistance is a common clinical problem in lung cancer. However, the underlying mechanisms have not yet been fully elucidated, highlighting the importance of searching for biological targets.

Methods: Bioinformatics analysis is completed through downloaded public data (GSE21656, GSE108214, and TCGA) and specific R packages. The evaluation of cell proliferation ability is completed through CCK8 assay, colony formation, and EdU assay. The evaluation of cell invasion and migration ability is completed through transwell and wound-healing assays. In addition, we evaluated cell cisplatin sensitivity by calculating IC50.

Results: Here, we found that PCDH7 may be involved in cisplatin resistance in lung cancer through public database analysis (GSE21656 and GSE108214). Then, a series of in vitro experiments was performed, which verified the cancer-promoting role of PCDH7 in NSCLC. Moreover, the results of IC50 detection showed that PCDH7 might be associated with cisplatin resistance of NSCLC. Next, we investigated the single-cell pattern, biological function, and immune analysis of PCDH7. Importantly, we noticed PCDH7 may regulate epithelial–mesenchymal transition activity, and the local infiltration of CD8+ T and activated NK cells. Furthermore, we noticed that patients with high PCDH7 expression might be more sensitive to bortezomib, docetaxel, and gemcitabine, and resistant to immunotherapy. Finally, a prognosis model based on three PCDH7-derived genes (GPX8, BCAR3, and TNS4) was constructed through a machine learning algorithm, which has good prediction ability on NSCLC patients’ survival.

Conclusion: Our research has improved the regulatory framework for cisplatin resistance in NSCLC and can provide direction for subsequent related research, especially regarding PCDH7.
Differential networks for processing structural dependencies in human language: linguistic capacity vs. memory-based ordering
Authors: Umejima Keita , Nakamura Isso , Fukui Naoki , Zushi Mihoko , Narita Hiroki , Sakai Kuniyoshi L.
Published: July 2023

Surface linear (left-to-right) arrangements of human languages are actually an amalgam of the core language system and systems that are not inherently related to language. It has been widely recognized that an unbounded array of hierarchically structured linguistic expressions is generated by the simplest combinatorial operation “Merge,” and the notion of Merge-generability has been proposed as a key feature that characterizes structural dependencies among linguistic elements. Here we tested Merge-generable dependencies by using a Subject-Predicate matching task, which required both linguistic capacity and short-term memory. We used three types of dependency: Nesting, Crossing, and Grouping as the control. The Nesting dependency istotallyMerge-generable, while the Crossing dependency requires some additional processes for memory-based ordering. In order to identify the regions employed for these two dependencies, we directly compared cortical responses to the sentence stimuli (with noun phrases and an adverb as the first half of stimuli, and with verbs as the latter) using functional magnetic resonance imaging (fMRI), and the following results were obtained. First, for the Nesting – Crossing contrast, significant activations were observed in the bilateral lateral premotor cortices (LPMCs) and inferior frontal gyri, left middle temporal gyrus, and bilateral angular/supramarginal gyri, indicating engagement of the syntax-related networks. In contrast, the Crossing – Nesting contrast showed focal activations in the left fusiform gyrus, lingual gyrus, and middle occipital gyrus (L. FG/LG/MOG). Secondly, for the first half of the Nesting stimuli, signal changes in the bilateral LPMCs were well fitted with the estimates of computational costs to search the workspace and to select items (Σ operations). Moreover, for the latter half of the Crossing stimuli, the signal changes in the L. FG/LG/MOG were differentially fitted with the estimates of loads related to the ordering of elements/words (numbers of Ordering). Thirdly, these fitting models were by far more likely than the exchanged estimates between bilateral LPMCs and L. FG/LG/MOG, confirming a double dissociation for primary processes with Σ and Ordering. In conclusion, these results indicate that separate cortical networks are differentially employed, and their careful elucidation will provide further insights and challenges.