bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of hemostasis system state indicators in severe COVID-19
Authors: Tikhomirova I. A. , Ryabov M. M.
Published: January 2022

Introduction. Clinical experience in managing patients with a new coronavirus infection caused by the SARS-CoV-2 allowed to identify specific hemostasis disorders, and enables to introduce the concept of COVID-associated coagulopathy. The aim of the study was to assess the direction of coagulogram parameter changes, whole blood clotting parameters and characteristics of platelet and plasma hemostasis in patients with severe COVID-19. Materials and methods. The parameters of the hemostasis system were assessed using venous blood of 12 patients with severe COVID-19 and 16 healthy volunteers. The whole blood clotting process was investigated by low-frequency piezothromboelastography. The platelet count and indicators of spontaneous and ADP-induced platelet aggregation were estimated with the help of a laser platelet aggregation analyzer. Fibrinolytic activity of plasma, plasminogen activity, content of fibrinogen, D-dimer, PTT, APTT, PTI and INR were assessed. Results. An increased level of fibrinogen, a 6-fold increased D-dimer level, and increased PTT were found in patients with severe COVID-19. The patient platelets count was reduced by 51 % (p <0.05), spontaneous platelet aggregation remained at nearly normal level. Almost complete inhibition of ADP-induced platelet reactivity and inhibition of XIIa-dependent fibrinolysis was revealed, despite an increased by 19.3 % (p <0.05) plasminogen activity. Parameters of the whole blood coagulation process pointed a pronounced activation of platelet hemostasis, a significant intensification of the polymerization stage of clot formation and an increased intensity of clot lysis and retraction. Conclusion. The significant increase of D-dimer level and paradoxical inhibition of plasma fibrinolytic activity revealed by test of XIIa-dependent fibrinolysis (in contrast to the increased intensity of clot lysis when assessing the coagulation of whole blood) indicate the complex pathogenic mechanisms of coagulopathy caused by SARS-CoV-2 infection, and the involvement of blood cells and the vascular wall in the process of pathological thrombus formation.
Learning and Teaching en Dos Idiomas: Critical Autoethnography, Translenguaje, y Rechazando English Learner
Authors: Navarro Martell Melissa Arabel
Published: January 2022

Language usage in US K–12 classrooms and beyond continues to be an issue of equity (Navarro Martell, 2021; Palmer et al., 2019). Teachers expect racialized students who appear to be Latinx to know and perform as if their native language is Spanish, mientras a otros se les celebra sus intentos de usar el español; otro idioma colonizador. Some educators know language can be used as a tool to teach content y que muchos adultos translenguamos mientras navegamos espacios profesionales y personales, not because of our lack of mastery of English or Spanish, pero porque tenemos la habilidad y el poder de navegar y vivir en varios idiomas. Entonces, why are many educators determined to force students to use only one language at a time cuando el translanguage es tan común (Martínez et al., 2015)? This essay provides reflections and lessons learned of one immigrant, formerly labeled “English learner,” who was once a fourth and eighth grade math and science dual language teacher. Inspired by critical autoethnography, this manuscript is written by a current math and science bilingual methods teacher educator and supporter of translanguaging in the P–20+ classroom.
Centering Translanguaging in Teacher Education: Cultivando Nuevos Conocimientos de Translenguaje en la Educación de Docentes Bilingües
Authors: Ramírez Pablo C. , Garza Ayala Armando
Published: January 2022

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Bilingualism and Bilingual Education: Conceptos Fundamentales
Authors: Armijo Romero Minea
Published: January 2022

N/A
Nota Editorial
Authors: Editorial Equipo
Published: January 2022

La literatura pensada como un espacio de creación humana ha dado cabida a otras artes, pero también a otras disciplinas, que pueden ser englobadas en las diversas expresiones de la ciencia y de la filosofía. En este sentido, la historiografía literaria ha evidenciado que, a lo largo de los siglos, ha existido un punto de interacción entre estos ámbitos culturales. Aun con ello, todavía se juzga, a priori, que éstos se mantienen muy distantes el uno del otro, de los otros. Sin embargo, un análisis somero -que hoy en día toca los campos de expresión teórica de lo inter y lo transdisciplinario, con un amplio rango de metodologías- revela que el diálogo entre distintos campos disciplinarios lleva a pensar la literatura desde una óptica muy reveladora.
Imaginación, subjetividad y compromiso: Sartre y las potencias de la ficción
Authors: Quepons Ramírez Ignacio
Published: January 2022

Con base en una sistematización general de la fenomenología de lo imaginario de Sartre, el artículo propone las pautas para la reconstrucción de un concepto de ficción con base en las premisas de la filosofía de Sartre. Con ello, es posible aclarar la relación entre ficción y subjetividad y, por otro lado, sugerir una reflexión en torno a las potencias de la ficción que permita elucidar el sentido en el que puede comprenderse la noción sartreana de compromiso. En la primera parte, se presenta el papel de la imaginación y lo imaginario en los estudios literarios de Sartre. En la segunda parte, se presenta un esquema sobre la dialéctica de la reflexión y el papel de lo imaginario en la configuración de la subjetividad. Finalmente, y con base en la argumentación anterior, se plantea una interpretación fenomenológica del ensayo ¿Qué es literatura?, para sugerir inmediatamente después cómo la interpretación materialista de lo imaginario, sugerida por Sartre al final de sus días, se refiere a un concepto de ficción que se encuentra implícito en sus estudios literarios.Imagination, subjectivity and commiment: Sartre and the fiction potencysAbstractDeparting from a general systematization of Sartre’s phenomenology of the imaginary, the article proposes guidelines for the reconstruction of a concept of fiction based on the premises of Sartre’s philosophy. With this, it is possible to clarify the relationship between fiction and subjectivity and, on the other hand, to suggest a reflection on the powers of fiction that allows us to elucidate the sense in which Sartre’s notion of commitment can be understood. The first part presents the role of the imagination and the imaginary in Sartre’s literary studies. The second part presents an outline of the dialectic of reflection and the role of the imaginary in the configuration of subjectivity. Finally, and based on the previous argumentation, a phenomenological interpretation of the essay What is Literature?, is proposed in order to suggest immediately afterwards how the materialist interpretation of the imaginary, suggested by Sartre at the end of his days, refers to a concept of fiction that is implicit in his literary studies. Enviado a dictamen: 10 de noviembre de 2021Aceptación: 29 de noviembre 2021
“Parte del ayre”: el concepto del pneuma y el beso erótico
Authors: Sol Mora Pablo
Published: January 2022

El concepto del pneuma –“aire”, “aliento”– aparece ya en la filosofía presocrática y posteriormente en el corpus hippocraticum y las obras de Platón y Aristóteles. Es un término filosófico y médico que tiene que ver con la materia que constituye el universo y el proceso de respiración. Después, pasa al pensamiento paulino y da pie al pneuma cristiano. En tanto el beso, desde la Antigüedad, se consideró un intercambio de alientos, el concepto del pneuma está estrechamente relacionado con él. Este artículo rastrea su historia desde sus orígenes clásicos hasta el Renacimiento y muestra cómo se volvió un elemento indispensable en la representación del beso. “Parte del ayre”: The Concept of Pneuma and the Erotic KissAbstractThe concept of pneuma –“air”, “breath”– appears in the Presocratic philosophy and later in the corpus hippocraticum and the works of Plato and Aristotle. It is a philosphical and medical term related to the origins of the universe and the process of breathing. Afterwards, saint Paul elaborates on it and gives birth to the Christian pneuma. Since Antiquity, the kiss was considered to be an exchange of breaths. This paper traces pneuma’s history from its classical origins to the Renaissance and shows how it became key in kisses in literature. Enviado a dictamen: 10 de noviembre 2021Aceptación: 24 de noviembre 2021
Miguel Capistrán. Contemporáneos y otras lecturas
Authors: Lima Martínez Diego Armando
Published: January 2022

Miguel Capistrán. (2020). Contemporáneos y otras lecturas, 269 pp. ISBN: 978-607-98946-1-0. Xalapa. Universidad Veracruzana-Academia Mexicana de la Lengua.En el último de los casos que resolvió Erik Lönnrot, enigmático protagonista de “La muerte y la brújula”, Jorge Luis Borges disolvió las diferencias que separaban las dos grandes pasiones de su relato: el misterio policiaco y la lectura. En Lönnrot, podemos encontrar, a un mismo tiempo, la labor del crítico literario y la del investigador criminalista.
Carlos Fuentes y los horizontes de la traducción literaria
Authors: Ahumada Aguirre Javier
Published: January 2022

Norma Angélica Cuevas Velasco y Ricardo Corzo Ramírez (Eds. y Coords.). (2020). Carlos Fuentes y los horizontes de la traducción literaria. 314 pp. ISBN UV: 978-607-502-860-6 y Colsan: 978-607-8666-72-0. Xalapa: Universidad Veracruzana/El colegio de San Luis. Un mito fundacional del Antiguo Testamento, el de la torre de Babel, explica el origen de la variedad lingüística del hombre como un escarmiento divino, cuyo objetivo era imposibilitar la comprensión mutua de las tribus humanas y dispersarlas por la tierra.
THE STATUS OF THE UNAFFECTED EYE IS A PREDICTOR OF SHORT-TERM RECOVERY IN A CROATIAN COHORT OF PATIENTS WITH MONOCULAR OPTIC NEURITIS
Authors:   Department of Ophthalmology, Clinical Hospital Centre Osijek, Osijek, Croatia, Jelić Vuković Marija ,   Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Matić Suzana ,   Department of Ophthalmology, Clinical Hospital Centre Osijek, Osijek, Croatia,   Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Barać Josip ,   Department of Ophthalmology, Clinical Hospital Centre Osijek, Osijek, Croatia,   Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Biuk Dubravka ,   Department of Ophthalmology, Clinical Hospital Centre Osijek, Osijek, Croatia,   Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Pivić Kovačević Ivana Pivić Kovačević ,   Department of Ophthalmology, Clinical Hospital Centre Osijek, Osijek, Croatia,   Faculty of Medicine, Josip Juraj Strossmayer University of Osijek
Published: January 2022

Aim: To define the clinical profile of patients with unilateral optic neuritis (ON) presented to our clinic and to identify baseline clinical features and demographic data associated with one-month visual acuity (VA) outcome. Methods: Patients with suspected ON referred to our clinic were consecutively assessed for inclusion between February 2017 and November 2019. VA was measured using Snellen charts. Clinical and demographic, baseline and after one-month follow-up data were analyzed in a multivariate model. Results: Overall, 71 patients were included, of which six were considered lost to follow-up. The median age was 50 years old (interquartile range 37-57 years old) and the female to male ratio was 3:1. 14.1 % had a severe attack and 83.1 % recovered completely one month after the diagnosis. Multivariate analysis of data from 65 patients showed that baseline VA of the affected eye (P=0.011) and fellow eye (P=0.015) were factors associated with VA of the affected eye at follow up. Conclusion: Our cohort was older, had a higher female to male ratio and on average, a less severe ON clinical presentation compared to reports from other countries. Baseline VA of both the affected and fellow eye are predictors of one-month VA recovery
RESEARCH OF CANCER CASES AMONG LONG-LIVED WOMEN IN LVIV REGION (UKRAINE) DURING 1991–2019 YEARS
Authors:   SI «Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine», Lviv, Ukraine, Kitsera Nataliya ,   Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine, Shparyk Yaroslav ,   Lviv Oncological Regional Medical and Diagnostic Center, Lviv, Ukraine, Tril Orest ,   Lviv Oncological Regional Medical and Diagnostic Center, Lviv, Ukraine, Dvulit Zoriana ,   Lviv Polytechnic National University, Lviv, Ukraine
Published: January 2022

Cancer is the second leading cause of death worldwide. Aim of our study was to describe the spectrum of cancer among longlivers women in Lviv region (Ukraine) from database during 1991-2019. Material and methods. We studied 444 longlivers women aged 90+ who were diagnosed of cancer, treated and followed-up. Results. 104 women (23%) were diagnosed cancer to stage I, II -142 (32%), III -71 (10%), IV -57 (13%):other malignant neoplasms of skin (38.29%), breast (9.46%), colon (6.98%) and pancreas (4.95%) cancer. Diagnosis was confirmed cytology -169 (38.1%), histology-139 (31.3%). CT and MRI were used in rare cases in older women – 11(2.5%). Half of the women (227 or 51.13%) lived beyond 1 year after diagnosis. The rest is from 1 to 13 years. The relationship between life expectancy after diagnosis of cancer and type of treatment is weak (Сramer ratio ; Pearson's criterion ). Detected that the relationship between life expectancy after diagnosis and the age of patients at the time of oncologic diagnosis is weak too (Сramer ratio ; Pearson's criterion ). The relationship between life expectancy after diagnosis and stage of cancer is strong (Сramer ratio ; Pearson's criterion ). Conclusion. Aggressive anticancer treatments are less commonly used in cancer patients aged 90+, which may be one of the reasons for poorer survival due to comorbidities and natural causes. Life expectancy has relationship on the stage of the cancer, but does not have relationship on the age of the long-lived women and the type of treatment.
FROM BASIC SCIENCES TO CLINICAL APPLICATIONS WITH A SYMPOSIA SERIES: A GLOBAL OUTREACH
Authors:   School of Medicine, American University of Health Sciences, Signal Hill/Long Beach, CA, USA, Szabo Sandor
Published: January 2022

Dissemination of research results between scientists usually happens via publications of original papers & review articles published in strictly controlled, peer-reviewed scientific journals. This is certainly a beneficial and useful way of communication, but it does not cover all the needs in scientific interactions. This manuscript aims to highlight the unmet need for effective creative communication among scientists during international conferences and congresses. A brief history of the 35-years symposia series “International Symposia on Cell/Tissue Injury & Cytoprotection/Organoprotection” (ISCTICO) are presented
A DEEP DIVE INTO THE BASICS OF DEEP LEARNING
Authors:   Memorial Sloan Kettering Cancer Center, Department of Medical Physics, New York, New York, USA, Wolansky Ivan
Published: January 2022

Deep learning is a type of machine learning (ML) that is growing in importance in the medical field. It can often perform better than traditional ML models on different metrics, and it can handle non-linear problems due to activation functions. Activation functions are different non-linear functions that are used to restrict the values propagated to an interval. In deep learning, information propagates forward, passing through different layers of weights and activation functions, before reaching the final layer. Then a cost function is evaluated and propagated back through the network to adjust weights. A convolutional neural network (CNN) is a form of deep learning that is used primarily in imaging. CNNs perform significantly well with grid-like inputs because they learn shapes well. CNNs compute dot products between layers and kernels in a convolutional layer, prior to pooling, which outputs summary statistics. CNNs are better than trivial neural networks for imaging due to a number of reasons, like sparse interaction and equivariance of translation
A Comparison of Structure, Stability of Neutral and Cationic Vanadium-doped Germanium Clusters GenV0/+ (n = 2 - 8) by using Density Function Theorym clusters GenV0/+ (n = 2 - 8) by using density function theory
Authors: Huu Tho Nguyen , Cam Pham Hong
Published: January 2022

The geometries, stabilities and electronic properties of vanadium-doped germanium clusters GenV0/+ (n=2-8) were systematically investigated by using density functional theory (DFT) at the PBE level and the 6-311+G(d) basis set. The results show that the geometries of lowest-energy structures of the cationic clusters are only significant different from those of the neutral at n = 6 or 7. The ground state of neutral clusters is a doublet, except Ge2V which is a quartet while that of cationic clusters is a triplet, except Ge8V+, which is a singlet. The average binding energy values generally increase with increasing cluster size. The results from average binding energies showed that it is more stable for the cationic than neutral clusters at the same size. Furthermore, the calculated values of fragmentation energy, second-order energy difference, HOMO-LUMO gap and adiabatic ionization potential suggest that the neutral clusters possess higher stability when n = 2, 5, 8 and the cations are more stable when n = 2, 3, 5 and 6.
The New Deep Web Drug Market Place (And the role of Bitcoin as a currency for drugs)
Authors: IYER SURYA , RAJESWARI G. RAJA , R ARUNA , JAYAKRISHNAN BALAJI
Published: January 2022

Drugs are a true menace to our society today. “Drug use on the rise” is an increasingly common headline in newspapers and it is well-known that this is the case. With the topic of drugs becoming more and more common in popular media, youngsters are especially influenced to try drugs. This is not a new problem, as such, and has been a relevant issue in modern society. Coupled with this, the internet plays a huge role in spreading information about emerging drugs (such as synthetic and ‘designer’ drugs). [2] This paper aims to understand the role of the internet’s Deep Web [3] and Bitcoin (and other Crypto currencies) in dealing drugs online.
PRESTIGE OF THE TEACHING PROFESSION AND THE LEVEL OF INTELLIGENCE DEVELOPMENT AMONG STUDENTS PEDAGOGICAL UNIVERSITIES
Authors: KIBYSH ANATOLY , YURCZAK DARIUSZ
Published: January 2022

The main purpose of this study is an attempt to draw the attention of the scientific community to the problem of the prestige of the teaching profession against the background of the opinion that has developed in modern society about the low level of intelligence of applicants of pedagogical universities. This problem is relevant today for many European countries, including Poland, where the first stage of research was conducted. A wide range of studies conducted by scientists from Poland, Ukraine and Russia (a list of names is given in the text of the article) indicates the continuing interest of the scientific community in the problem of the prestige of the teaching profession. However, there are not enough publications linking the prestige of the profession and the intelligence of students studying in this direction in the scientific environment. Most publications on this topic do not have scientifically confirmed facts, but are based only on emotions and public perception of the problem. Therefore, we decided to conduct a number of studies in the universities of the three listed countries in order to confirm or decline the prevailing opinion about the low intellectual development of applicants of pedagogical universities. Our research (the first stage) was conducted on the basis of the Warsaw University of Natural Sciences among first-year students studying in the direction of "Pedagogy" using survey as a research method, in particular the Raven test. The article publishes only partial results of research conducted at this Polish higher educational institution, which, nevertheless, allow us to refute the thesis about the low level of intellectual development among students of pedagogical directions. These data are presented in comparison with the similar situation in Ukraine and Russia, which allows us to conclude that the prestige of the teaching profession as a pan-European trend is falling (in relation to the countries of the Eastern Europe). The research results also contradict the generally accepted opinion about the low level of intelligence among students of pedagogical educational institutions. Most of them have an average and high level (according to the Raven test), which, however, does not directly affect the prestige of the teaching profession. More than half of the respondents do not intend to work in their primary specialty, but consider pedagogical education prestigious for further career outside of school.
METHODOLOGICAL FEATURES OF FORMATION OF THE CULTURE OF CRITICAL THINKING OF PRIMARY SCHOOLCHILDREN
Authors: LIONENKO MARIIA
Published: January 2022

The article deals with the methods and techniques for the development of critical thinking of primary schoolchildren, which are fundamentally different from the reproductive style of learning. The development of critical thinking of students can largely meet the requirements of modernity, namely: the content of education is considered not as a material for learning, but as a material for research; the student in this system is one of the main subjects of cooperation; the teacher, acting as an assistant, encourages students to maximum cognitive activity, maintains a creative psychological climate through co-creativity with students. It is noted that for the quality organization of the educational process and achievement of the set goals it is important to correctly apply the tools and methods of development of critical thinking. The article suggests a detailed description of the basic methods and techniques for the development of critical thinking and features of their application at primary school lessons. It is noted that the technologically correct application of methods and techniques for the development of critical thinking will promote active learning of students and form a culture of critical thinking.
FORMING PRIMARY SCHOOL PUPIL’S EDUCATIONAL AND COGNITIVE ACTIVITY WHILE WORKING WITH DIGITAL INFORMATION
Authors: SHYSHAK ANDRIANA
Published: January 2022

The relevance of the research topic is due to the fact that educational and cognitive activities of pupils are formed in the primary school years. A pupil learns the system of competencies gradually, which influences the development of his cognitive mental processes. Taking into consideration the fact that the field of education is in the stage of digitalization, pupils of primary school work with digital information during the educational process. The work with digital data itself is a means of forming educational and cognitive activities of junior pupils. The purpose of the article is to specify the essence of the concepts “educational and cognitive activity” and “digital information”; investigate the features of the formation of educational and cognitive activities of pupils of primary school while working with digital information.

In the article educational-cognitive activity is substantiated as activity which is directed on mastering a system of competencies. Therefore development of its cognitive mental processes is carried out. Being a complex category, its components are the educational and cognitive activities of a learner. One of the means of forming educational and cognitive activities of pupils of primary school are work with digital information. It is specified that digital information is information, the creation, storage, transmission and processing of which is carried out by means of information and communication technologies. In the context of digitalization of primary education, the specifics of the gradual acquisition of knowledge, skills, abilities and experience of cognition by the pupils of primary school while working with digital information are outlined: perception, comprehension and understanding, generalization, consolidation and application. The characteristic features of cognitive activity of primary school pupils (sensation, perception, memory, thinking, attention, imagination and speech) were analyzed through the prism of their work with digital information, which are caused by the specific form of educational material and the age characteristics of pupils of primary school. It is determined that motivation is the basis for the formation of educational and cognitive activities of pupils of primary school while working with digital materials; the motives of educational and cognitive activities that relate to the interaction of primary school pupils with digital information are characterized: the desire to learn something new, the desire to learn new ways of action, the desire to work with information and digital media.
PSYCHOLOGICAL AND PEDAGOGICAL POTENTIAL OF HUMOUR AS A MEANS OF TEACHING AND NURTURING PRIMARY SCHOOL PUPILS
Authors: PYSARCHUK OKSANA , CHAIKA VOLODYMYR
Published: January 2022

The relevance of the article is stipulated to the active search for qualitatively new ways to improve the efficiency of the educational process in primary school. One of them is humour as a special property of human nature. The use of elements of humour in the organization of the educational process in primary school, methods and techniques based on wit, has significant psychological and pedagogical potential and is a significant reserve for improving the effectiveness of learning, education and personality development of primary school. The application of forms of humour with pupils of primary school in work contributes to the development of personal qualities of pupils, the formation of their critical thinking, the ability to make decisions independently and creatively approach any business. The purpose of the article is to determine the psychological and pedagogical potential of humour as a means of teaching and nurturing pupils of primary school.

Various approaches to the interpretation of the essence of the concept of “humour” are analyzed in the article; the complexity of the nature of humour is grounded, which is stipulated to synthetic combinations of communicative, emotional and intellectual spheres, personal traits of a child, socio-cultural conditions of its formation. The problem of application of elements of humour during the organization of educational process in establishments of general secondary education in the context of scientific developments of known scientists (Ya. A. Komensky, A. Makarenko, V. Sukhomlinsky, Sh. Amonashvili, O. Savchenko) is investigated. The psychological and pedagogical potential of humour as a means of teaching and nurturing pupils of primary school, which provides a set of all available tools, opportunities for humor that can be used in teaching and educational process in general, and identified a set of psychological and pedagogical conditions to increase its productivity: creating an atmosphere of cooperation and trust through the skillful use of humorous methods and techniques; adequacy of humor to the peculiarities of the development of the emotional sphere of junior pupils; organic use of humor in the content of educational material. The role of the influence of humor elements on the emotional sphere of junior pupils during the organization of the educational process in primary school is substantiated. The relationship of value emotional states (interest, joy, surprise) with the mental processes of the individual (memory, will, thinking) during the use of elements of humour in primary school lessons is analyzed. The forms of humour in the life of pupils of primary school, the peculiarities of their formation and development in accordance with the age category are reflected.
PRIVATE PRESCHOOL EDUCATION INSTITUTIONS AS AN ALTERNATIVE TO STATE INSTITUTIONS FOR EDUCATIONAL TRAINING OF PRESCHOOL CHILDREN
Authors: RUDENSKIY ROSTISLAV , ZHARKOVA IRYNA
Published: January 2022

It is noted that the development of a progressive society is dynamic, with a tendency to constantly accelerate, complicate and change, so the integration of Ukraine into the international educational space is the main task of Ukrainian education in general and preschool education in particular. Preschool education is not only a system of knowledge for its transmission to the younger generation, but also the most important means of creating a successful future for all mankind, and the key goal of education is a mature and educated person. It is noted that private preschools can become an effective alternative to public kindergartens only if the requirements set out in the State Standard for Preschool Education are met. The current state of the network of preschool educational institutions (PEI) of different types and forms of ownership (public, municipal, private, corporate, family) is analysed and regional indicators of the end of 2020 – beginning of 2021 are taken into account. It is determined that private and corporate PEI can help to solve national problems with groups overcrowding, low quality of educational and developmental environment organization (subject-spatial, psychological-didactic, social-communication and motivational-cognitive components), inclusive education organization, implementation of ideas of the best international experience, insufficient number of PEI in Ukraine.
The effect of orthodontic treatment with fixed appliances on sleep quality in adults and adolescents in Saudi Arabia using Pittsburgh sleep quality index
Authors: Alkadhi Omar Hamad , Alomran Ali A. , Alrafee Nawaf S. , Alaresh Faisal A. , Alqahtani Marzouq S. , Talic Faisal N.
Published: January 2022

Objectives:

The aim of this study was to investigate the effect of pain caused by orthodontic fixed appliances on sleep quality of participants using the Pittsburgh Sleep Quality Index (PSQI).

Materials and Methods:

A previously validated Arabic version of PSQI was electronically distributed through different social media platforms and in waiting areas of orthodontic offices. Eligibility criteria included healthy adults and adolescents with orthodontic fixed appliances and with no systemic conditions that may affect sleep. The cut-off point used to determine poor sleep quality was (>5).

Results:

Three hundred and eighteen participants were included in the final analysis (28.9% males and 71.1% females). Both males and females with orthodontic fixed appliances had poor sleep quality with (Mean = 6.48, SD = 2.85, P = 0.000) for males, and (Mean = 7.18, SD = 2.87, P = 0.000) for females. Comparing males and females, we found that females scored higher than males in both subjective sleep quality and PSQI global score.

Conclusion:

Individuals undergoing orthodontic treatment with fixed appliances have poor sleep quality. Females undergoing orthodontic treatment tend to have poorer sleep quality compared to males.
Evaluation of white spot lesions around orthodontic brackets using different bonding agents – An in vivo study
Authors: Vashishta Vaibhav , Kaul Rakesh , Singh Ankita , Kapoor Sudhir , Grover Sulabh , Singhal Monisha
Published: January 2022

Objectives:

The objectives of the study were to assess the white spot lesions around orthodontic bracket macroscopically using two different bonding agents – one with amorphous calcium phosphate (ACP) (Aegis Ortho) and one without ACP (Transbond XT).

Materials and Methods:

The study comprises 10 patients from 14 to 23 years of age. Patients were divided into control and study groups. Forty premolar teeth were then observed (20 teeth in each group). Bonding procedure was done and brackets were positioned on all four 1st pre-molars teeth and pre-treatment photographs were taken. The experimental material used was Aegis Ortho composite (study group) and Transbond XT (control group). Debonding procedure (by Wing deformation technique) was performed after 16 weeks which led to adhesive fracture at composite resin adhesive bracket interface leaving essentially all adhesive on the enamel. Then, follow-up photographs were taken to evaluate each.

Results:

Aegis Ortho containing ACP used for bonding purpose, provided lesser enamel demineralization than Transbond XT.

Conclusion:

Aegis Ortho for orthodontic bonding is significantly more beneficial and reliable, however, further investigations are also required to understand its clinical performance better.
A case of Stage III essential hypertension treated with homoeopathy through the windows of the unconscious mind: A case report
Authors: Patil Manoj Kishor
Published: January 2022

A 36-year-old man presented with Stage III accelerated hypertension and reluctance to start anti-hypertensive medication. This case is an attempt to demonstrate the importance of unconscious emotions and dreams with their psychodynamic correlations in essential hypertension through the portrait of disease. Mag carb was selected based on the totality of symptoms in view of the evolution of person, dispositions and adaptive patterns along with available physical characteristics through the psychodynamic study.
Localization of irritative zones in epilepsy with thermochromic silicone
Authors: de Font-Réaulx Enrique , Terrazo-Lluch Javier , Díaz-López Luis Guillermo , Collado-Corona Miguel Ángel , Shkurovich-Bialik Paul , González-Astiazarán Adalberto
Published: January 2022

Background:

During epilepsy surgery, the gold standard to identify irritative zones (IZ) is electrocorticography (ECoG); however, new techniques are being developed to detect IZ in epilepsy surgery and in neurosurgery in general, such as infrared thermography mapping (ITM), and the use of thermosensitive/thermochromic materials.

Methods:

In a cohort study of consecutive patients with focal drug-resistant epilepsy of the temporal lobe treated with surgery, we evaluated possible adverse effects to the transient placement of a thermochromic/thermosensitive silicone (TTS) on the cerebral cortex and their postoperative evolution. Furthermore, we compared the precision of TTS for detecting cortical IZ against the gold standard ECoG and with ITM, as proof of concept.

Results:

We included 10 consecutive patients, 6 women (60%) and 4 men (40%). Age ranges from 15 to 56 years, mean 33.2 years. All were treated with unilateral temporal functional lobectomy. The mean hospital stay was 4 days. There were no immediate or late complications associated with the use of any of the modalities described. In the 10 patients, we obtained consistency in locating the IZ with ECoG, ITM, and the TTS.

Conclusion:

The TTS demonstrated biosecurity in this series. The accuracy of the TTS to locate IZ was similar to that of ECoG and ITM in this study. More extensive studies are required to determine its sensitivity and specificity.
Recurrent ossification of the posterior longitudinal ligament in the upper thoracic region 10 years after initial decompression
Authors: Segi Naoki , Ando Kei , Nakashima Hiroaki , Machino Masaaki , Ito Sadayuki , Koshimizu Hiroyuki , Tomita Hiroyuki , Imagama Shiro
Published: January 2022

Background:

Posterior decompression surgery consisting of laminoplasty is generally considered be the treatment of choice for upper thoracic OPLL. Here, we describe a patient who, 10 years following a C3–T4 level laminectomy, developed recurrent OPLL at the T2–3 level with kyphosis requiring a posterior fusion.

Case Description:

A 64-year-old male with CT documented OPLL at the C3–4, C6–7, and T1–4 levels, originally underwent a cervicothoracic laminectomy with good results. However, 10 years later, when T2–3 OPLL recurred along with kyphosis, he warranted an additional posterior fusion.

Conclusion:

Due to the long-term risks of developing kyphotic deformity/instability, more patients undergoing initial decompressive surgery alone for upper thoracic OPLL should be considered for primary fusions.
Adult gangliocytoma arising within the lateral ventricle: A case report and review of the literature
Authors: Alarifi Norah , Del Bigio Marc R. , Beiko Jason
Published: January 2022

Background:

Gangliocytomas are rare neuronal tumors with an incidence of <1% of all central nervous system (CNS) neoplasms. They occur mostly in the pediatric age group, localizing within the cerebral cortex, most often the temporal lobe.

Case Description:

We report a case of an intracranial gangliocytoma arising within the lateral ventricle in a 66-year-old female. Magnetic resonance imaging of the brain showed a diffusely enhancing lobulated mass situated within the frontal horn of the right lateral ventricle with extension into the foramen of Monro and obstructive hydrocephalus. The patient underwent an interhemispheric transcallosal approach with gross total resection and relief of her hydrocephalus. Pathological examination showed clusters of highly pleomorphic neuron-like cells without evidence of neoplastic glial cells. Histopathological and immunohistochemistry findings were consistent with the diagnosis of gangliocytoma (World Health Organization Grade 1).

Conclusion:

Gangliocytomas are rare low-grade CNS neoplasms that can present in an older population within unusual locations and should be included within the differential whenever a suspicious lesion is encountered.
SYNTHESIS OF MACROCYCLES FROM COMPLEX NICKEL SALTS
Authors: Ильясов Д.С. , Ильясов С.Г.
Published: January 2022

Исследовано взаимодействие комплексной соли хлорида никеля (II) с диаминомочевиной в присутствии глиоксаля. Получены различные комплексные соли катионного типа на основе никеля (II) с диаминомочевиной и на их основе были синтезированы соответствующие макроциклические соединения. Полученные комплексы и макроциклы исследованы физико-химическими методами анализа.

The interaction of a complex salt of nickel (II) chloride with diamino urea in the presence of glyoxal was studied. Various complex salts of the cationic type based on nickel (II) with diamino urea were obtained and the corresponding macrocyclic compounds were synthesized on their basis. The resulting complexes and macrocycles were studied by physicochemical methods of analysis.
SYNTHESIS OF 2-NITRO-1,3-BIS(3,3’-DIHYDROXYMETHYL)-1,2,3-TRIAZOLYL-2-AZAPROPANE BY THE REACTION OF AZIDE-ALKYN CYCLOADDITION
Authors: Шестакова Е.О. , Щурова И.А. , Ильясов С.Г.
Published: January 2022

2-Нитро-1,3-бис(3,3'-дигидроксиметил)-1,2,3-триазолил-2-азапропан (2-НДТАП) представляет интерес в качестве исходного вещества в синтезе высокоэнергетических соединений. В статье рассмотрен синтез 2-НДТАП реакцией азид-алкинового циклоприсоединения 1,3-диазидо-2-нитро-2-азапропана с пропаргиловым спиртом в среде трет-бутилового спирта в присутствии медного катализатора (проволока, порошок меди, оксид меди, нанооксид меди). Исследовано влияние катализатора и температуры процесса на его продолжительность, выход и качество продукта. Структура 2-НДТАП подтверждена методами ИК- и ЯМР-спектроскопии. В результате разработан метод получения 2-НДТАП с выходом 62 % и содержанием основного вещества выше 97 %.

2-Nitro-1,3-bis (3,3'-dihydroxymethyl)-1,2,3-triazolyl-2-azapropane (2-NDTAP) is of interest as a starting material in the synthesis of high-energy compounds. The article discusses the synthesis of 2-NDTAP the reaction of azide-alkyne cycloaddition 1,3-diazido-2-nitro-2-azapropane with propargyl alcohol in tert-butyl alcohol in the presence of a copper catalyst (wire, copper powder, copper oxide, nano copper oxide). The influence of the catalyst and the temperature of the process on its duration, yield and product quality has been investigated. The structure of 2-NDTAP was confirmed by IR and NMR spectroscopy. As a result, a method for obtaining 2-NDTAP with a yield of 62 % and a basic substance content of more than 97 % was developed.
METHOD FOR THE PREPARATION OF 2,4,6-TRIHYDROXYTOLUENE FROM 2,4,6-TRINITROTOLUENE
Authors: Щурова И.А. , Алексеева Н.А. , Сысолятин С.В. , Малыхин В.В.
Published: January 2022

Статья посвящена усовершенствованию способа получения 2,4,6-тригидрокситолуола, востребованного химического реагента в синтезе азокрасителей и пигментов, а также химико-фармацевтических препаратов и различных полимеров. Основным сырьем для его получения является 2,4,6-тринитротолуол, который подвергают каталитическому гидрированию с последующим гидролизом образовавшегося 2,4,6-триаминотолуола. В данной работе предложены условия многоциклового использования палладиевого катализатора гидрирования 2,4,6-тринитротолуола, позволяющие сохранять активность катализатора и повысить выход 2,4,6-триаминотолуола выше 98 %. Аминопроизводное выделяется в виде дисульфата действием концентрированной серной кислоты. Кроме того, изучено влияние соотношения вода/дисульфат 2,4,6-триаминотолуола на выход 2,4,6-тригидрокситолуола; найдены условия, в которых выход на стадии гидролиза увеличен до 83-84 %. Проведен сравнительный анализ различных способов выделения 2,4,6-тригидрокситолуола из реакционной массы.

The paper is concerned with upgrading the synthetic method for 2,4,6-trihydroxytoluene, an in-demand chemical reactant in the synthesis of azo-dyes and pigments, as well as chemical pharmaceuticals and various polymers. The basic feedstock for the synthesis thereof is 2,4,6-trinitrotoluene, which is subjected to catalytic hydrogenation followed by hydrolysis of the resulting 2,4,6-triaminotoluene. Here we suggest conditions for the multicycle use of Pd catalyst employed for the hydrogenation of 2,4,6-trinitrotoluene, which allow the catalyst activity to be retained and the yield of 2,4,6-triaminotoluene to be enhanced above 98%. The amino derivative is liberated as the disulfate by concentrated sulfuric acid. Moreover, we examined how the ratio of water / 2,4,6-triaminotoluene disulfate influences the yield of 2,4,6-trihydroxytoluene. Conditions were found in which the yield from hydrolysis is 83-84 %. Different methods for the isolation of 2,4,6-trihydroxytoluene from the reaction mixture were comparatively analyzed.
AUTOMATION HR PROCESSES
Authors: Крылова Е.А. , Бережнова В.К.
Published: January 2022

Статья посвящена изучению эффективных инструментов для автоматизации HR процессов. Чтобы разобраться в современных цифровых технологиях и быстро меняющихся условиях в области HR, специалисту по кадровому производству необходимо интегрировать в свою работу инновационные IT-инструменты, одним из которых является внедрение корпоративного программного обеспечения. Проведено исследование инструментов управления персоналом в условиях глобальной цифровизации, выявлены положительные и отрицательные аспекты автоматизации HR процессов. Рассмотрен вопрос развития автоматизации HR процессов в условиях эпидемиологической ситуации. Приведены наиболее перспективные ИТ-технологии в управлении персоналом. Автоматизация HR процессов экономит время, которое кадровый работник может использовать для выполнения других важных задач. Для этого на языке программирования PYTHON разработан проект извлечения телефонных номеров и адресов электронной почты. Данный проект протестирован на браузере страницы контактов сайта Ykt.ru.

The article focuses on the study of effective tools for automating HR processes. To understand modern digital technologies and the rapidly changing environment in the field of HR, an HR specialist needs to integrate innovative IT tools into his work, and one of such tools is the implementation of corporate software. A study of human resources management tools in the context of global digitalization is carried out, the positive and negative aspects of the automation of HR processes are identified. The issue of the development of automation of HR processes in the context of an epidemiological situations is considered. The most promising IT technologies in personnel management are presented. Automating HR processes saves time that an HR worker can use to complete other important tasks. For this purpose, a project for extracting telephone numbers and e-mail addresses has been developed in the Python programming language. This project has been tested on the browser of the contact page of the website of Ykt.ru
INFLUENCE OF POROSITY OF PRESSED SAMPLES OF SUPERFINE ALUMINUM POWDER ON COMBUSTION PARAMETERS
Authors: Попов В.О. , Комов В.Н. , Попенко Е.М. , Сергиенко А.В.
Published: January 2022

Данная статья посвящена исследованию влияния пористости прессованных таблеток из сверхтонкого порошка алюминия (СТП Al). Определен механизм горения, протекающий в две стадии: первая, медленная, включающая в себя как «кольцевое» горение боковой поверхности, так и параллельное горение концентрическими слоями, вторая стадия объемная, сопровождающаяся резким самопроизвольным увеличением температуры горения и интенсивности свечения. Показано, что увеличение плотности упаковки СТП Al позволяет замедлить процесс окисления алюминия более чем в два раза. Это обусловлено снижением газопроницаемости таблетки и затруднением доступа воздуха вглубь образца. Повышение пористости материала позволяет регулировать процесс нитридообразования за счёт увеличения содержания азота в продуктах при фильтрационном механизме горения, что открывает возможности получения тугоплавких материалов.

This article is devoted to the study of the effect of porosity of compressed tablets from ultrafine aluminum powder (STP Al). The combustion mechanism was determined, which proceeds in two stages: the first, slow, which includes both "ring" combustion of the side surface and parallel combustion with concentric layers, the second stage is volumetric, accompanied by a sharp spontaneous increase in the combustion temperature and glow intensity. It has been shown that an increase in the packing density of HFC Al makes it possible to slow down the process of aluminum oxidation by more than two times. This is due to a decrease in the gas permeability of the tablet and the difficulty of air access deep into the sample. An increase in the porosity of the material makes it possible to regulate the process of nitride formation by increasing the nitrogen content in the products during the filtration mechanism of combustion, which opens up the possibility of obtaining refractory materials.