bluuebunny/crossref_metadata_2025 huggingface dataset:
EE score: an index for simple differentiation of homozygous hemoglobin E and hemoglobin E-β0-thalassemia
Authors: Singha Kritsada , Fucharoen Goonnapa , Sanchaisuriya Kanokwan , Fucharoen Supan
Published: April 2018

Background:

The objective of the study was to describe a formula based on hemoglobin (Hb)A2 and HbF levels for differentiation of homozygous HbE and HbE-β-thalassemia.

Methods:

A total of 1256 subjects suspected for homozygous HbE or HbE-β0-thalassemia were recruited at the ongoing thalassemia screening program at Khon Kaen University, Thailand. Hb analysis was done using capillary electrophoresis. Genotyping was based on DNA analysis. An arbitrary formula based on HbA2 and HbF was developed statistically for differentiation of the two conditions. Validation was carried out prospectively on another 139 subjects encountered at routine laboratory.

Results:

Among 1256 subjects, Hb and DNA analyses identified cases with homozygous HbE (n=1076, 85.7%), HbE-β0-thalassemia (n=140, 11.1%), HbE-δβ0-thalassemia (n=30, 2.4%) and unknown HbE-related disorder (n=10, 0.8%). An inverse correlation between the amounts of HbA2 and HbF in HbE-β0-thalassemia was observed. With differences in the amounts of HbA2 and HbF between the groups, an arbitrary score (7.3 HbA2+HbF) was developed where score above 60 indicated HbE-β0-thalassemia. Application of this score on another 139 subjects showed accurate prediction of HbE-β0-thalassemia with 100% sensitivity, 96.5% specificity, 85.7% positive predictive value and 100% negative predictive value. Successful application onto couples at risk was demonstrated.

Conclusions:

An established score should prove useful in the differentiation of homozygous HbE and HbE-β0-thalassemia in routine setting and lead to a significant reduction in number of referring cases for molecular testing.
Progress in the treatment of fungal infections of the central nervous system
Authors: Li Xuemei , Li Xiaoxia
Published: April 2018

The incidence of fungal infections of the central nervous system (CNS) has gradually increased in recent years. Intracranial fungal infection can be classified as diffuse and focal infections. The clinical manifestations of these infections include fever and cranial pressure caused by meningitis or meningoencephalitis, as well as focal neurological defects caused by lesions in the intracranial space. Diagnosing fungal infections of the CNS requires comprehensive analysis of the patient’s medical history, epidemiology, underlying disease, clinical manifestation, imaging manifestations, and results from various laboratory tests. The identification of fungal bodies or structures in brain tissue or cerebrospinal fluid specimens is the golden standard of diagnosis. The principles for the treatment of fungal infections of the CNS are the effective control of pathogenic risk factors, use of effective antifungal drugs, and the active implementation of surgical intervention for fungal abscesses and granulomas. In the meantime, new diagnoses and treatments should be actively explored to improve the prognosis of patients.
NADPH promotes the rapid growth of the tumor
Authors: Hao Sheng
Published: April 2018

NADPH oxidase is the main source of intracellular reactive oxygen species (ROS). ROS plays an important role in a variety of tumor types. The ROS mediated by NADPH oxidase increases the expression of hypoxia-inducible factor alpha (HIF-α) through multiple signaling pathways in tumor, and HIF-α could be regulated and controlled by downstream multiple targeted genes such as vascular endothelial growth factor, glucose transporter to promote tumor angiogenesis, cell energy metabolism reprogram and tumor metastasis. Meanwhile, HIF-α can also regulate the expression of NADPH oxidase by ROS, thus further promoting development of tumor. In this review, we summarized the functions of NADPH in tumorigenesis and discussed their potential implications in cancer therapy.
Modelling of Chemical Reactors: From Systemic Approach to Compartmental Modelling
Authors: Haag Jérémie , Gentric Caroline , Lemaitre Cécile , Leclerc Jean-Pierre
Published: April 2018

To take into account the impact of hydrodynamics on their behavior, chemical reactors are traditionally modeled as an association of smaller ideal reactors: perfectly stirred or plug flow reactors. This modeling is mainly based on the reactor hydrodynamics but sometimes also on phenomena governing the considered process such as heat or mass transfer or chemical reaction. The approaches encountered in the literature start from the most basic one in which the whole reactor is considered as an ideal reactor, up to a very fine discretization using Computational Fluid Dynamics (CFD). In between, the reactor can be described as an association of a small number of ideal reactors: this is the systemic approach. Another intermediate approach has also been recently developed: the compartmental method, where all compartments are assumed to be perfectly mixed. In the compartment method, the compartment number is significantly more important than in the systemic approach - but lower than for CFD. Furthermore, these compartments are chosen to be relevant regarding their position in space as opposed to systemic models in which, in most of cases, only the global physical behavior is taken into account. Compared to CFD, compartment models are less computationally demanding while taking into account the most important flow features. The present review describes the different types of modeling commonly used in chemical reaction engineering during the last 60 years from the systemic approach to CFD, with a focus on the attractive compartmental modelling. In particular, the methodologies encountered to determine the compartment structure are detailed, as well as the different possibilities to determine the turbulent fluxes between compartments.
Tenckhoff tunneled peritoneal catheter placement in the palliative treatment of malignant ascites: technical results and overall clinical outcome
Authors: Maleux Geert , Indesteege Inge , Laenen Annouschka , Verslype Chris , Vergote Ignace , Prenen Hans
Published: April 2018

Background

To assess the technical and clinical outcome of percutaneous insertion of tunneled peritoneal catheters in the palliative treatment of refractory malignant ascites and to determine the safety and feasibility of intraperitoneal administration of cytotoxic drugs through the tunneled catheter.

Materials and methods

Consecutive patients palliatively treated with a tunneled peritoneal catheter to drain the malignant ascites were identified. Patients’ medical history, procedural and clinical follow-up data, including complications and estimated survival, were reviewed. Additionally, a sub analysis of the patients with widespread ovarian cancer and refractory ascites treated with or without intraperitoneal administration of cytotoxic drugs was made.

Results

In all 94 patients it was technically feasible to insert the peritoneal drainage catheter and to drain a median of 3260 cc (range 100 cc – 8500 cc) of malignant ascitic fluid. Post procedural complications included catheter infection (n = 2; 2%), fluid leakage around the entry site (n = 4; 4%), catheter occlusion (n = 2; 2%), sleeve formation around the catheter tip (n = 1; 1%) and accidental loss of the catheter (n = 1; 1%). There was no increase in catheter infection rate in patients treated with or without intraperitoneal administration of cytotoxic drugs. Median overall survival after catheter insertion is 1.7 months.

Conclusions

Percutaneous insertion of a tunneled Tenckhoff catheter for the palliative drainage of malignant ascites and intraperitoneal infusion of cytotoxic drugs is feasible and associated with a very low complication rate, including catheter infection. These tunneled peritoneal lines are beneficial for symptomatic palliative treatment of refractory ascites and allow safe intraperitoneal chemotherapy.
Electrochemotherapy in pancreatic adenocarcinoma treatment: pre-clinical and clinical studies
Authors: Bimonte Sabrina , Leongito Maddalena , Granata Vincenza , Barbieri Antonio , Vecchio Vitale del , Falco Michela , Nasto Aurelio , Albino Vittorio , Piccirillo Mauro , Palaia Raffaele , Amore Alfonso , Giacomo Raimondo di , Lastoria Secondo , Setola Sergio Venanzio , Fusco Roberta , Petrillo Antonella , Izzo Francesco
Published: April 2018

Background

Pancreatic adenocarcinoma is currently one of the deadliest cancers with high mortality rate. This disease leads to an aggressive local invasion and early metastases, and is poorly responsive to treatment with chemotherapy or chemo-radiotherapy. Radical resection is still the only curative treatment for pancreatic cancer, but it is generally accepted that a multimodality strategy is necessary for its management. Therefore, new alternative therapies have been considered for local treatment.

Conclusions

Chemotherapeutic resistance in pancreatic cancer is associated to a low penetration of drugs into tumour cells due to the presence of fibrotic stroma surrounding cells. In order to increase the uptake of chemotherapeutic drugs into tumour cells, electrochemotherapy can be used for treatment of pancreatic adenocarcinoma leading to an increased tumour response rate. This review will summarize the published papers reported in literature on the efficacy and safety of electrochemotherapy in pre-clinical and clinical studies on pancreatic cancer.
Medical physics in Europe following recommendations of the International Atomic Energy Agency
Authors: Casar Bozidar , Lopes Maria do Carmo , Drljević Advan , Gershkevitsh Eduard , Pesznyak Csilla
Published: April 2018

Background

Medical physics is a health profession where principles of applied physics are mostly directed towards the application of ionizing radiation in medicine. The key role of the medical physics expert in safe and effective use of ionizing radiation in medicine was widely recognized in recent European reference documents like the European Union Council Directive 2013/59/EURATOM (2014), and European Commission Radiation Protection No. 174, European Guidelines on Medical Physics Expert (2014). Also the International Atomic Energy Agency (IAEA) has been outspoken in supporting and fostering the status of medical physics in radiation medicine through multiple initiatives as technical and cooperation projects and important documents like IAEA Human Health Series No. 25, Roles and Responsibilities, and Education and Training Requirements for Clinically Qualified Medical Physicists (2013) and the International Basic Safety Standards, General Safety Requirements Part 3 (2014). The significance of these documents and the recognition of the present insufficient fulfilment of the requirements and recommendations in many European countries have led the IAEA to organize in 2015 the Regional Meeting on Medical Physics in Europe, where major issues in medical physics in Europe were discussed. Most important outcomes of the meeting were the recommendations addressed to European member states and the survey on medical physics status in Europe conducted by the IAEA and European Federation of Organizations for Medical Physics.

Conclusions

Published recommendations of IAEA Regional Meeting on Medical Physics in Europe shall be followed and enforced in all European states. Appropriate qualification framework including education, clinical specialization, certification and registration of medical physicists shall be established and international recommendation regarding staffing levels in the field of medical physics shall be fulfilled in particular. European states have clear legal and moral responsibility to effectively transpose Basic Safety Standards into national legislation in order to ensure high quality and safety in patient healthcare.
Use of Bivalirudin for Anticoagulation in Interventional Cardiovascular Procedures
Authors: Ge Zhen , Chandrasekhar Jaya , Mehran Roxana
Published: April 2018

Anticoagulation is imperative to reduce the incidence of thrombotic complications in patients undergoing percutaneous interventional cardiovascular procedures; however, this is at the expense of increased risk of bleeding. The optimal anticoagulation strategy for these procedures remains unclear. Unfractionated heparin is the most commonly used anticoagulant during interventional procedures, but has several limitations, such as relatively high incidence of bleeding events, occurrence of heparin-induced thrombocytopenia, and a paradoxical thrombotic effect. Contemporary studies have demonstrated that bivalirudin decreases the occurrence of bleeding complications, but potentially increases the risk of acute stent thrombosis. This review discusses the pharmacology of bivalirudin and its current clinical application in patients undergoing percutaneous coronary intervention and transcatheter aortic valve replacement procedures.
Translatome Regulation in Neuronal Injury and Axon Regrowth
Authors: Rozenbaum Meir , Rajman Marek , Rishal Ida , Koppel Indrek , Koley Sandip , Medzihradszky Katalin F. , Oses-Prieto Juan A. , Kawaguchi Riki , Amieux Paul S. , Burlingame Alma L. , Coppola Giovanni , Fainzilber Mike
Published: April 2018

Transcriptional events leading to outgrowth of neuronal axons have been intensively studied, but the role of translational regulation in this process is not well understood. Here, we use translatome analyses by ribosome pull-down and protein synthesis characterization by metabolic isotopic labeling to study nerve injury and axon outgrowth proteomes in rodent dorsal root ganglia (DRGs) and sensory neurons. We identify over 1600 gene products that are primarily translationally regulated in DRG neurons after nerve injury, many of which contain a 5’UTR cytosine-enriched regulator of translation (CERT) motif, implicating the translation initiation factor Eif4e in the injury response. We further identified approximately 200 proteins that undergo robust de novo synthesis in the initial stages of axon growth. ApoE is one of the highly synthesized proteins in neurons, and its receptor binding inhibition or knockout affects axon outgrowth. These findings provide a resource for future analyses of the role of translational regulation in neuronal injury responses and axon extension.
Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor–Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK
Authors: Kotzadimitriou Dimitrios , Nissen Wiebke , Paizs Melinda , Newton Kathryn , Harrison Paul J. , Paulsen Ole , Lamsa Karri
Published: April 2018

Hypofunction ofN-methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder with many susceptibility genes. However, it is still unclear how SZ risk genes interfere with NMDAR-mediated synaptic transmission in diverse inhibitory interneuron populations. One putative risk gene is neuregulin 1 (NRG1), which signals via the receptor tyrosine kinase ErbB4, itself a schizophrenia risk gene. The type I isoform ofNRG1shows increased expression in the brain of SZ patients, and ErbB4 is enriched in GABAergic interneurons expressing parvalbumin (PV) or cholecystokinin (CCK). Here, we investigated ErbB4 expression and synaptic transmission in interneuronal populations of the hippocampus of transgenic mice overexpressing NRG1 type I (NRG1tg-type-Imice). Immunohistochemical analyses confirmed that ErbB4 was coexpressed with either PV or CCK in hippocampal interneurons, but we observed a reduced number of ErbB4-immunopositive interneurons in the NRG1tg-type-Imice. NMDAR-mediated currents in interneurons expressing PV (including PV+basket cells) or CCK were reduced in NRG1tg-type-Imice compared to their littermate controls. We found no difference in AMPA receptor–mediated currents. Optogenetic activation (5 pulses at 20 Hz) of local glutamatergic fibers revealed a decreased NMDAR-mediated contribution to disynaptic GABAergic inhibition of pyramidal cells in the NRG1tg-type-Imice. GABAergic synaptic transmission from either PV+or CCK+interneurons, and glutamatergic transmission onto pyramidal cells, did not significantly differ between genotypes. The results indicate that synaptic NMDAR-mediated signaling in hippocampal interneurons is sensitive to chronically elevated NGR1 type I levels. This may contribute to the pathophysiological consequences of increasedNRG1expression in SZ.
Distribution of Spinal Neuronal Networks Controlling Forward and Backward Locomotion
Authors: Merkulyeva Natalia , Veshchitskii Aleksandr , Gorsky Oleg , Pavlova Natalia , Zelenin Pavel V. , Gerasimenko Yury , Deliagina Tatiana G. , Musienko Pavel
Published: April 2018

Higher vertebrates, including humans, are capable not only of forward (FW) locomotion but also of walking in other directions relative to the body axis [backward (BW), sideways, etc.]. Although the neural mechanisms responsible for controlling FW locomotion have been studied in considerable detail, the mechanisms controlling steps in other directions are mostly unknown. The aim of the present study was to investigate the distribution of spinal neuronal networks controlling FW and BW locomotion. First, we applied electrical epidural stimulation (ES) to different segments of the spinal cord from L2 to S2 to reveal zones triggering FW and BW locomotion in decerebrate cats of either sex. Second, to determine the location of spinal neurons activated during FW and BW locomotion, we used c-Fos immunostaining. We found that the neuronal networks responsible for FW locomotion were distributed broadly in the lumbosacral spinal cord and could be activated by ES of any segment from L3 to S2. By contrast, networks generating BW locomotion were activated by ES of a limited zone from the caudal part of L5 to the caudal part of L7. In the intermediate part of the gray matter within this zone, a significantly higher number of c-Fos-positive interneurons was revealed in BW-stepping cats compared with FW-stepping cats. We suggest that this region of the spinal cord contains the network that determines the BW direction of locomotion.

SIGNIFICANCE STATEMENTSequential and single steps in various directions relative to the body axis [forward (FW), backward (BW), sideways, etc.] are used during locomotion and to correct for perturbations, respectively. The mechanisms controlling step direction are unknown. In the present study, for the first time we compared the distributions of spinal neuronal networks controlling FW and BW locomotion. Using a marker to visualize active neurons, we demonstrated that in the intermediate part of the gray matter within L6 and L7 spinal segments, significantly more neurons were activated during BW locomotion than during FW locomotion. We suggest that the network determining the BW direction of stepping is located in this area.
Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75NTR signal pathway
Authors: Zhang Fan , Chen Jian , Lin Xinyue , Peng Shiqiao , Yu Xiaohui , Shan Zhongyan , Teng Weiping
Published: April 2018

Objective

Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH) on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring.

Methods

Female adult Wistar rats were randomly divided into three groups (n = 15 per group): control (CON) group, SCH group and overt hypothyroidism (OH) group. Spatial learning and memory in the offspring were evaluated by long-term potentiation (LTP) and Morris water-maze (MWM) test. The protein expression of the p75 neurotrophin receptor (p75NTR), phospho-c-Jun N-terminal kinase (p-JNK), the pro-apoptotic protein p53 and Bax were detected by Western blotting.

Results

The Pups in the SCH and OH groups showed longer escape latencies in the MWM and decreased field-excitatory post synaptic potentials in LTP tests compared with those in the CON group. p75NTR, p-JNK, p53 and Bax expression levels in the cerebral cortex increased in pups in the SCH and OH groups compared with those in the CON group.

Conclusions

Maternal SCH during pregnancy may impair spatial learning and memory in the offspring and may be associated with the increased apoptosis in the cerebral cortex.
The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells
Authors: Shao Weijuan , Szeto Vivian , Song Zhuolun , Tian Lili , Feng Zhong-Ping , Nostro M Cristina , Jin Tianru
Published: April 2018

Pancreatic β-cell Tcf7l2 deletion or its functional knockdown suggested the essential role of this Wnt pathway effector in controlling insulin secretion, glucose homeostasis and β-cell gene expression. As the LIM homeodomain protein ISL1 is a suggested Wnt pathway downstream target, we hypothesize that it mediates metabolic functions of TCF7L2. We aimed to determine the role of ISL1 in mediating the function of TCF7L2 and the incretin hormone GLP-1 in pancreatic β-cells. The effect of dominant negative TCF7L2 (TCF7L2DN) mediated Wnt pathway functional knockdown on Isl1 expression was determined in βTCFDN mouse islets and in the rat insulinoma cell line INS-1 832/13. Luciferase reporter assay and chromatin immunoprecipitation were utilized to determine whether Isl1 is a direct downstream target of Tcf7l2. TCF7L2DN adenovirus infection and siRNA-mediated Isl1 knockdown on β-cell gene expression were compared. Furthermore, Isl1 knockdown on GLP-1 stimulated β-catenin S675 phosphorylation and insulin secretion was determined. We found that TCF7L2DN repressed ISL1 levels in βTCFDN islets and the INS-1 832/13 cell line. Wnt stimulators enhanced Isl1 promoter activity and binding of TCF7L2 on Isl1 promoter. TCF7L2DN adenovirus infection and Isl1 knockdown generated similar repression on expression of β-cell genes, including the ones that encode GLUT2 and GLP-1 receptor. Either TCF7L2DN adenovirus infection or Isl1 knockdown attenuated GLP-1-stimulated β-catenin S675 phosphorylation in INS-1 832/13 cells or mouse islets and GLP-1 stimulated insulin secretion in INS-1 832/13 or MIN6 cells. Our observations support the existence of TCF7L2–ISL1 transcriptional network, and we suggest that this network also mediates β-cell function of GLP-1.
Features of Social and Educational Support of Young Parents and their Children
Authors: Mykhailyshyn Halyna , Budnyk Olena
Published: April 2018

The article presents social and educational aspects of early (teenage) pregnancy, young motherhood. The authors grounded negative consequences of early pregnancy and the peculiarities of social and educational support for young parents and their children. The authors described experience Centre for Teen Parents: moral and psychological preparation of pregnant teenagers to deliver the baby, directions and methods of working with young families, especially setting up comfortable psychological interaction using innovative methods of working with preschool children, providing conditions for young mothers to continue education in schools, counseling young families on resolving housing issues, financial support and others.

The paper emphasizes the need for preventive work to keep teenagers from pregnancy, carrying out social and educational events in terms of promoting healthy and responsible parenthood and others
Contemporary Ukrainian Literature for Children and Youth in the Context of Multiculturalism as an Educational Practice
Authors: Kachak Tetiana , Blyznyuk Tetyana
Published: April 2018

The article outlines the problem of relevance of multiculturalism in Ukrainian society and educational practice of the modern Ukrainian school. The authors analyze the artistic works by Oksana Lushchevska, addressed to young readers, representing the coexistence of various forms of cultural life, highlighting the problem of preserving one's own and perceiving another cultural identity, tolerant interaction of representatives of various ethnic groups. Simultaneously, the novel by American writer Rainbow Rowell focused on negative phenomena of interethnic interaction, but offered readers an interesting and multifunctional artistic text in terms of receptive poetics and aesthetics. Considered in the paper works can be an effective means of multicultural education and upbringing of schoolchildren
Insertion / Deletion Polymorphism of Angiotensin Converting Enzyme Gene Does Not Contribute to Chronic Kidney Disease in Palestine
Authors: Abuaisha Asmaa Mahmoud , Marzoq Lamia Faisal Abou , Eljbour Mai Sufian , Fayyad Eman Saad , Baraka Abeer Kamal , Serakinci Nedime
Published: April 2018

Background: Chronic Kidney Disease (CKD) is progressive kidney damage in which the glomerular filtration rate (GFR) decreases by 15% of that performed by normal kidneys, with the result that the kidneys are no longer to function effectively and this condition is treated with either kidney transplantation or dialysis. Hemodialysis (HD) is a process in which the blood passes through a machine (dialyzer) to remove waste. Angiotensin Converting Enzyme (ACE) is one of the major components of the renin-angiotensin aldosterone system (RAAS) that is responsible for blood pressure regulation. Insertion/Deletion I/D polymorphism of a 287 bp Alu repeat sequence in introns 16 of the ACE gene results in three genotypes I/D, D/D and I/I. The aims of this study were to evaluate ACE genotypes and allele frequency among HD patients and control subjects and to examine the association between ACE genotypes with HD risk.

Methods: A retrospective case-control study included 186 subjects, 86 HD patients and 100 healthy individuals as a control. EDTA whole blood samples were collected from all participants for DNA extraction, and the ACE gene polymorphism was analyzed by using the Polymerase Chain Reaction (PCR) technique. Additionally, all individuals were requested to complete the questionnaire.

Results: The initial results demonstrated that the D/D genotype was the most common genotype in all subjects and the association between ACE genotypes with HD occurrence was not statistically significant in the Gaza Strip-Palestine. Furthermore, no statistically significant association was detected between the polymorphism and the study groups (p-value = 0.511).
Notas sobre uma história da fotografia na América Latina
Authors: Etcheverry Carolina Martins
Published: April 2018

MRAZ, John; MAUAD, Ana Maria. Fotografía e historia en América Latina. Montevideo: Intendencia de Montevideo/Centro de Fotografia de Montevideo, 2015. 262 p.
Más allá de la simple imagen: fotografía e investigación
Authors: Rius Núria F.
Published: April 2018

***Além de imagens simples: fotografia e pesquisa***LAIS. Tejedores de imágenes. Propuestas metodológicas de investigación y gestión del patrimonio fotográfico y audiovisual. México, DF: Instituto Mora, 2014. 311 p.
Marxismo y filosofía de la vida: las reflexiones tempranas de Siegfried Kracauer sobre la Revolución Rusa y los comienzos de la Unión Soviética
Authors: Vedda Miguel
Published: April 2018

El artículo analiza las reflexiones tempranas de Kracauer sobre la Revolución Rusa de octubre de 1917, sobre la figura y la significación de Lenin y sobre los primeros años de la Unión Soviética. Destaca las “afinidades electivas” que el ensayista alemán encuentra entre sus propios puntos de vista y el “método” de Lenin y Trotski pone estas reflexiones en relación con la obra posterior de Kracauer.
Educação, justiça e configuração social na América Portuguesa no Século XVII
Authors: Montagnoli Gilmar Alves , Costa Célio Juvenal
Published: April 2018

Este artigo tem como objetivo analisar a administração da justiça na América portuguesa do século XVII, com base em pressupostos da teoria de Norbert Elias. Mais especificamente, as Ordenações Filipinas, código jurídico publicado no ano de 1603 fornecem elementos para pensar mecanismos de controle presentes na obra eliasiana. Parte-se do entendimento de que, tal como propõe a teoria, as Ordenações expressam o esforço de controle do Estado sobre os indivíduos, possível graças à monopolização da violência física pelo Estado. A norma expressa o anseio de controlar as ações humanas, coibindo comportamentos indesejados e motivando práticas tidas como ideais no contexto. Traduz a necessidade de regulamentação das atividades do Estado e, mais especificamente, das ações individuais, expressando a constante correspondência entre estrutura social e estrutura do ser individual. Além da força física, são identificados dispositivos capazes de despertar sentimentos com condições de atuar na internalização de hábitos.
Atividades miméticas e dispositivos de controle no Colégio Americano Batista no Recife
Authors: Souza Edilson Fernandes , Simões José Luís , Costa Marcos André Nunes
Published: April 2018

À luz da teoria eliasiana, o artigo apresenta as atividades miméticas incentivadas no Colégio Americano Batista, criado na cidade do Recife, em 1906, e os seus dispositivos institucionais publicados para orientar e controlar os estudantes no cotidiano educacional. A análise concentra-se em fontes como o Prospecto de 1918, o Regulamento Disciplinar de 1920 e o Decálogo de 1925. Constata-se que a Instituição Educacional Batista tinha como objetivo o desenvolvimento do self-control em seus estudantes, permitindo jogos parlamentares e atléticos e proibindo, simultaneamente, impulsos contrários à Lei do Governo Próprio e o Cavalheirismo no Jogo. Assim, o referido Colégio buscava afirmação de membros outsiders no campo educacional e cristão protestante.
O artístico no cotidiano: os significados da arte de Frida Kahlo nos calçados da Arezzo
Authors: Fabrin Maria Eduarda Carrenho , Baliscei João Paulo , Stein Vinícius
Published: April 2018

Ainda hoje, a vida e obra de Frida Kahlo, artista mexicana cuja estética é amplamente reconhecida, continuam repercutindo em imagens cinematográficas, bibliográficas e publicitárias. Nesse artigo, nosso objetivo é identificar e analisar as maneiras como as referências artísticas são veiculadas e consumidas nas visualidades contemporâneas. Para isso, investigamos duas produções distintas denominadas Viva la Vida. A primeira versão de Viva la Vida é uma pintura do gênero natureza-morta, elaborada por Frida Kahlo em 1954, pouco antes de seu falecimento. A segunda versão de Viva la Vida é uma coleção de bolsas e calçados produzida e divulgadas pela marca Arezzo ao longo de 2015. Quais as convergências expressivas apresentadas entre esses dois artefatos culturais? Quais os desdobramentos do artístico nas visualidades cotidianas? Respaldados no Estudo da Cultura Visual e nas referências oferecidas pelas duas versões de Viva la Vida, identificamos elementos de intersecção que aproximam a arte institucional às visualidades populares contemporâneas.
As paixões, as pulsões e as emoções humanas em Aristóteles, Freud e Norbert Elias: uma reflexão para a educação contemporânea
Authors: Carvalho Alonso Bezerra , Brandão Carlos Fonseca
Published: April 2018

Este artigo tem como objetivo discutir o papel e a importância das emoções no processo de constituição dos indivíduos e da própria sociedade e suas possíveis ressonâncias na educação. De caráter teórico, o texto parte da exposição da noção de emoções para autores como Aristóteles, Freud e Norbert Elias, defendendo a ideia de que o homem é marcado e constituído por uma dimensão que precisa ser retomada se quisermos compreendê-lo e, assim, contribuir de alguma maneira para os desafios que são enfrentados, por exemplo, por professores e alunos em uma sala de aula. Partimos da ideia de que as emoções pertencem à natureza humana, isto é, para conhecer os homens deveríamos começar a observar as suas ações apaixonadas, visto que elas podem indicar o caráter de um indivíduo e de um grupo. Nesse aspecto, a melhor maneira de se estabelecer estratégias para influenciar a conduta de uma pessoa está em considerar esse outro lado de sua existência. Na sala de aula, lugar formativo por excelência, esse debate se faz necessário, tendo em vista que ali se manifestam os mais diversos tipos de emoções, e que considerados, podem contribuir para uma formação mais ampla e integral do ser humano.
Duas leituras de um movimento: Norbert Elias e Ttheodor W. Adorno, sobre o processo civilizador
Authors: Vaz Alexandre Fernandez
Published: April 2018

No presente trabalho analiso um texto de Norbert Elias que corresponde ao discurso por ele proferido quando do recebimento do prêmio Theodor W. Adorno, em Frankfurt, 1977.  No texto de Elias, que se chama Discurso sobre Adorno: Respeito e Crítica, confluem comentários pessoais e teóricos sobre Theodor W. Adorno, seu contemporâneo, mas com o qual teve relação muito superficial. Os comentários de Elias estão centrados, em grande parte, nas dificuldades e apuros do humanismo marxista de Adorno. Suas críticas referem-se principalmente aos supostos limites impostos pelo pensamento de Marx às reflexões de Adorno. É esse o ponto principal de minha análise, na qual problematizo essa crítica de Elias, levantando argumentos que procuram contrariar as observações a respeito da Obra de Adorno, sobretudo no que se refere à sua relação com o marxismo.
O Programa Nacional Escola de Gestores da Educação Básica na Universidade Federal de viçosa-MG: impasses e perspectivas na visão do gestor
Authors: Souza Valdirene Eliane , Coelho Edgar Pereira , Vaz de Mello Rita Márcia Andrade
Published: April 2018

O presente artigo analisa os principais impasses e perspectivas da formação continuada de Gestores Escolares, e ao mesmo tempo se essa formação a distância no âmbito do Programa Nacional Escola de Gestores da Educação Básica (PNEGEB), ofertado pela Universidade Federal de Viçosa - MG, contribuiu para prática pedagógica desse profissional. Para responder aos questionamentos da pesquisa adotou-se como perspectiva metodológica a abordagem qualitativa. Foram utilizados como instrumentos para a coleta de dados: análise teórico-bibliográfica; análise da matriz curricular e dos documentos oficiais do PNEGEB; análise de dez TCCs dos cursistas/gestores da Zona da Mata Mineira período (2013-2014) e, aplicação de cinco questionário aos gestores já egressos pelo programa. Os resultados apontaram situações problemas importantes, onde fica explícito que a educação brasileira sofre com os mais diversos problemas e carências de origem socioeconômica e política. Indicaram ainda que os gestores entenderam que essa formação e a prática reflexiva foram fundamentais para uma mudança e uma consequente melhoria da atuação profissional. Ademais, as análises mostraram que essa formação continuada foi relevante em sua essência diante da prática pedagógica dos gestores.
O conceito de cidadania a partir da obra de T.H Marshall: conquista e concessão
Authors: Mastrodi Josué , Avelar Ana Emília Cunha
Published: April 2018

O objetivo deste artigo é abordar discussões acerca do quadro teórico trazido por T.H. Marshall em sua obra Citizenship and Social Class. Analisaremos a relação feita pelo autor entre o desenvolvimento da cidadania e a concretização dos Direitos Fundamentais; o “surgimento” dos direitos civis, políticos e sociais, dispostos didaticamente ao longo dos séculos XVIII, XIX e XX. Pretendemos identificar a teoria de Marshall à compreensão da realidade inglesa e salientar algumas implicações sobre a inadequação dessa análise ao contexto brasileiro.
Reabilitação estética e funcional em paciente com amelogênese imperfeita: Relato de caso
Authors: Holanda Rafaela Costa , Feitosa Diana Maria Arraes , Alves Karla Shangela Silva , Gonçalves Ginna Kércia Matos , Gouveia Thayla Hellen Nunes , Lobo Patrícia Leal Dantas
Published: April 2018

Introdução: A amelogênese Imperfeita constitui um distúrbio de caráter hereditário caracterizado pela formação anormal de esmalte, podendo ocorrer na dentição decídua como na permanente. O esmalte pode apresentar-se como hipoplásico, hipomaturado, hipocalcificado ou hipoplásico-hipomaturado com taurodontismo, surgindo de forma isolada ou associada a outras anomalias. Sua etiologia pode ser de origem local, sistêmica, genética ou idiopática. O diagnóstico deve ser preciso para proceder o tratamento adequado para cada caso, seja preventivo, interceptativo ou o acompanhamento. Objetivo: Este artigo tem como objetivo apresentar um caso clínico de um paciente com amelogênese imperfeita, o qual foi reabilitado estético e funcionalmente, por meio da técnica direta utilizando resinas compostas. Relato de caso: O relato do presente caso refere-se a uma paciente do gênero feminino, 11 anos de idade, que apresentou-se com queixa de “dentes escuros”, “vergonha de sorrir” e “dificuldade de higienizar”, apresentando sério comprometimento estético e funcional. Este caso foi realizado, incluindo, fase preventiva, restauradora e de manutenção, devolvendo estética e função ao paciente. Conclusão: O comprometimento do sorriso de um indivíduo apresenta grande impacto na sua vida, gerando desde problemas estéticos e funcionais até interferir seu convívio social e suas relações pessoais. Para minimizar estes problemas, o diagnóstico e tratamento devem ser realizados o mais precoce possível e de maneira conservadora e eficaz, a fim de manter e devolver as funções orais, com a finalidade de promover ao paciente bem estar geral, autoestima e consequentemente melhorar sua qualidade de vida.
Editorial
Authors: Da Silva Carlos Alberto
Published: April 2018

Editorial
Avaliação de fatores de risco para síndrome metabólica em grupo de funcionários de uma Escola Pública
Authors: Rodrigues Mayzza Campina , Silva Evanuzia Miranda da , Silva Bhárbara Karolline Rodrigues , Quaresma Fernando Rodrigues Peixoto , Sesti Luis Fernando Castagnino , Adami Fernando , Maciel Erika Da Silva
Published: April 2018

A Síndrome Metabólica é definida como um conjunto de alterações que aumentam os riscos de desenvolvimento de doenças crônicas não transmissíveis. Objetivos: avaliar a presença de fatores de risco associado à síndrome metabólica em funcionários de uma escola pública. Metodologia: Trata-se de um estudo de delineamento transversal, de natureza descritiva. As variáveis analisadas foram colesterol total, percentual de gordura, glicemia em jejum, triglicérides, pressão arterial sistólica e diastólica. O perímetro abdominal e o índice de massa corporal foram classificados de acordo com os critérios da Organização Mundial da Saúde. Para classificação de Síndrome Metabólica (SM) foram adotados os parâmetros do NCEP-ATPIII, para o nível de atividade física, utilizou o Questionário Internacional de Atividade Física (IPAQ), versão 8. A análise de dados foi realizada de forma descritiva e teste de comparação Resultados: Participaram da pesquisa 26 voluntários, entre os resultados destacam-se que 88,5% da população apresenta percentual de gordura elevado. Os critérios do NCEP-ATPIII caracterizaram SM em 19,2%. Para os indivíduos classificados com sobrepeso ou obesidade todas as demais variáveis apresentaram valores superiores àqueles classificados como eutróficos. A análise estatística indicou que há diferenças entre os grupos com significância nos indicadores de composição corporal sendo o conjunto dessas variáveis o principal fator de risco. Conclusão: Evidenciou-se que o público alvo apresenta riscos para SM e que, medidas educacionais de saúde para mudança no estilo de vida no ambiente laboral, poderiam ser adotadas como método de prevenção.
O enfermeiro da atenção básica no acolhimento aos familiares de usuários de substâncias psicoativas
Authors: Santos Carvalho Silas , Da Silva Suzarte Karla
Published: April 2018

As substâncias psicoativas são um problema de grande importância social e seu consumo tem sido crescente. A Atenção Básica, por sua vez, tem como um de seus princípios facilitar o primeiro acesso das pessoas ao sistema de saúde, inclusive daquelas que precisam de cuidado em saúde mental. O profissional de enfermagem confronta-se com obstáculos encontrados dentro da própria família, comunidade e resiliência pessoal do usuário, tornando-se um desafio o envolvimento da família e o comprometimento do usuário. Neste trabalho, foram analisadas informações obtidas dos bancos de dados bibliográficos (SCIELO, MEDLINE, LILACS e PUBMED) enfocando pesquisas sobre a prática da enfermagem no acolhimento aos familiares de usuários de substâncias psicoativas. Para isso, buscamos artigos científicos, livros e manuais nacionais publicados entre os anos de 2003 a 2016. As informações obtidas com este trabalho permitem observar a necessidade da capacitação dos profissionais de saúde nas práticas de acolhimento dos usuários de substâncias psicoativas e seus familiares, bem como alteração nos moldes de ensino no intuito de que saberes e práticas caminhem juntos.
The Performance of Zea mays as Influenced by NPK fertilizer Application
Authors: LAW-OGBOMO Kolawole Edomwonyi , LAW-OGBOMO Joyce Egberanwen
Published: April 2018

Field trials were made to estimate the effect of NPK 15:15:15 fertilizer on the growth and yield of maize were conducted over a two year period. NPK fertilizer applications significantly increase plant height, stem girth, number of leaves, leaf area, leaf area index, dry matter accumulation and yield. The optimum level of NPK 15:15:15 fertilizer for successful production of maize grains was 400 (60 kg N + 27.16 kg P + 49.80 kg K) kg / ha compound fertilizer based on the fact that it had the greatest dry cob yield (12.44 t / ha), grain yield (7.95 t /ha), relative grain yield (2.26) and 100-seeds weight (11.62g).
Determination on Genetic Variation for Morphological Traits and Yield Components of New Winter Wheat (Triticum aestivum L) Lines
Authors: ALIU Sali Ali , FETAHU Shukri
Published: April 2018

he genetic studies were conducted on six new winter wheat (Triticum aestivum L.) line during three years investigations developed in agro ecological conditions of Kosovo. Data for various morphological and yield traits were taken and analyzed for spike length (SL), plant height (PH), total dry matter (TDM), spike Weight (SW), grain weight per spike (GWS), yield (Y) and harvest index (HI). Field design consisted in a randomized blocks design (RBD) with three replications. Results indicated that the line 01KS as the most competitive genotypes produced significantly higher for SL (9.58 cm), GWS (2.37 g per spike) and grain yield (10.66 t ha-1) while lower yield was recorded at the line 04KS (8.02 t ha-1). The lowest SL (8.4 cm) belonged to line 06KS which was ranked as the least competitive genotype. The significantly higher total dry matter (TDM) was recorded at the wheat line 02KS on value 4.88 g, while the lowest (4.44 g) belonged to 04KS which was ranked as the last genotype. There was a positive and significant harvest index (HI) on value from 50.5% to 39.1%.
Comparison among Different Integrated Nutrition Management for Soil Micro and Macro Elements after Winter Wheat Harvesting and Yield
Authors: KHODAEI JOGHAN Aydin , Ghalavand Amir , AGHAALIKHANI Majid , GHOLAMHOSEINI Majid , DOLATABADIAN Aria
Published: April 2018

A comparative field experiment has been conducted in order to study the effect of chemical, organic and integrated nitrogen suppliment on micro and macro nutrient residue after wheat harvesting, at Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran. The treatments consisted in three groups that are chemical, organically and integrated of them. Nitrogen was supplied in different proportion from chemical and organic sources. Also, zeolite was applied in two ways: mixed with soil and mixed with cattle manure during composting. Before sowing and after wheat harvesting, macro and micro nutrient availability in the soil were examined. The results showed that, among treatments supplying with 100% nitrogen required from composted cattle manure amended with 10% (w/w) zeolite had the best effect on nutrition residue after wheat production because zeolite decreased nitrogen leaching during the manure composting. Crop yield was not statistically different between fertilizer treatments but the highest seed yield was achieved from supplying 50% nitrogen required from cattle manure compost and 50% by urea amended with 10% (w/w) zeolite. This study demonstrated that composted cattle manure amended with zeolite improves soil fertility after wheat production compared with chemical fertilization.
Comparison of Pattern Recognition, Artificial Neural Network and Pedotransfer Functions for Estimation of Soil Water Parameters
Authors: LAKZIAN Amir , BANNAYAN AVAL Mohammad , GORBANZADEH Nasrin
Published: April 2018

This paper presents the comparison of three different approaches to estimate soil water content at defined values of soil water potential based on selected parameters of soil solid phase. Forty different sampling locations in northeast of Iran were selected and undisturbed samples were taken to measure the water content at field capacity (FC), -33 kPa, and permanent wilting point (PWP), -1500 kPa. At each location solid particle of each sample including the percentage of sand, silt and clay were measured. Organic carbon percentage and soil texture were also determined for each soil sample at each location. Three different techniques including pattern recognition approach (k nearest neighbour, k-NN), Artificial Neural Network (ANN) and pedotransfer functions (PTF) were used to predict the soil water at each sampling location. Mean square deviation (MSD) and its components, index of agreement (d), root mean square difference (RMSD) and normalized RMSD (RMSDr) were used to evaluate the performance of all the three approaches. Our results showed that k-NN and PTF performed better than ANN in prediction of water content at both FC and PWP matric potential. Various statistics criteria for simulation performance also indicated that between kNN and PTF, the former, predicted water content at PWP more accurate than PTF, however both approach showed a similar accuracy to predict water content at FC.
Effect of different Planting Pattern of Wheat (Triticum aestivum) and Bean (Vicia faba) on Grain Yield, Dry Matter Production and Weed Biomass
Authors: ESKANDARI Hamdollah , GHANBARI Ahmad
Published: April 2018

An experiment was conducted in University of London, Kent, UK during the year 2003. The aim of experiment was to investigate the effects of planting pattern on performance of wheat and bean intercrops. A complete randomized block design with four replications was employed to compare the treatments. Treatments included wheat sole crop (W), Bean sole crop (B), within row intercropping (M1), row intercropping (M2) and mix cropping (M3). The density of intercropping was according to replacement design (one wheat replaced by three bean plants). The results showed that total dry matter achieved by intercrops was significantly higher than those achieved by either wheat or bean sole crop. Regarding to weed control, intercrops were more effective than sole crops, especially bean sole crop. Crops performance in terms dry weight, height and percentage of leaf, stem pod and ear was affected by cropping systems depending on crop species, where wheat showed more changes compared to bean . Grain yield, harvest index and thousand grain weights of wheat were decreased in intercropping while bean had reduction only in grain yield.
Distribution of Wild and Cultivated Grapes in Turkey
Authors: UZUN Ibrahim H , BAYIR Arzu
Published: April 2018

Turkey is one of main gene centers in the world for grapes. It is believed that cultivated grapes have their origins in Turkey and the surrounding countries. Vitis vinifera ssp sylvestris is the only wild grape species in this region. That is why Turkey has a very large amount of wild grapevine populations and grape cultivars which offer to grapevine breeders a valuable gene pool. Wild grapevines have significant characters for inducing the resistence to biotic and abiotic stress factors, such as resistance to lime, drought, pests and diseases. Turkey has over 1.600 local grape cultivars, among which the majority of them are conserved at the national grape collection vineyard in Tekirda?. They are mostly used as table grapes, dried grapes or for local consumptions. Wild grapes are distributed all over the country territory, mainly in the river basins and forests. Wild grape collection vineyards were established at some universities in Turkey. These grapevines will be screened for the resistance to biotic and abiotic stress factors.