bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating Head and Neck Porocarcinoma: Systematic Review with Special Emphasis on Surgical Safety Margins
Authors: Kučinskaitė Alvija , Ulianskaitė Gintarė , Pamedys Justinas , Stundys Domantas
Published: March 2024

Eccrine porocarcinoma, sharing many features with other skin tumours, is diagnostically challenging. A conventional biopsy might be misleading and surgical excision becomes a primary diagnostic tool and a treatment method. However, the data on surgical safety margins are not consistent. We present a systematic review analysing the surgical margins of porocarcinoma in the head and neck area, which was conducted across the PubMed, Cochrane, and Web of Science databases including studies published from inception to November of 2023. In this systematic review, the PRISMA-ScR checklist was used, and a Cohen’s Kappa coefficient of 0.92 was applied, indicating very good agreement between reviewers. Out of 529 identified articles, 18 studies yielding 20 cases in total were selected for a thorough analysis. Nine (45%) cases were observed in the facial regions, eight (40%) on the scalp, and three (5%) on the neck. The primary treatment of choice was wide local excision with safety margins ranging from 3 to 22 mm (mean: 10.1). It demonstrated that surgical margins do not differ by age or anatomic regions, with the main point of reference being the tumour size. As observed, the bigger the tumour, the wider the safety margins were. However, the limited disclosure of surgical safety margins in analysed case reports impeded our ability to define the minimum safety margins. Further investigation and a consensus on recommended safety margins are required.
Recent Developments in Multifunctional Coordination Polymers
Authors: Dragutan Ileana , Ding Fu , Sun Yaguang , Dragutan Valerian
Published: March 2024

This Special Issue of Crystals “Multifunctional Coordination Polymers: Synthesis, Structure, Properties and Applications” [...]
Significant Wave Height Forecasting Based on EMD-TimesNet Networks
Authors: Ouyang Zhuxin , Gao Yaoting , Zhang Xuefeng , Wu Xiangyu , Zhang Dianjun
Published: March 2024

Significant Wave Height (SWH) is a crucial parameter in ocean wave dynamics, impacting coastal safety, maritime transportation, and meteorological research. Building upon the TimesNet neural network, a recent advancement in the realm of time series prediction in deep learning, this study proposes an integrated approach combining Empirical Mode Decomposition (EMD) with TimesNet, introducing the EMD-TimesNet model for SWH forecasting. The TimesNet model’s multidimensional spatial mapping guarantees effective historical information extraction, while the EMD approach makes it easier to decompose subsequence characteristics inside the original SWH data. The predicted Root Mean Square Error (RMSE) and Correlation Coefficient (CC) values of the EMD-TimesNet model are 0.0494 m and 0.9936; 0.0982 m and 0.9747; and 0.1573 m and 0.9352 at 1 h, 3 h, and 6 h, respectively. The results indicate that the EMD-TimesNet model outperforms existing models, including the TimesNet, Autoformer, Transformer, and CNN-BiLSTM-Attention models, both in terms of overall evaluation metrics and prediction performance for diverse sea states. This integrated model represents a promising advancement in enhancing the accuracy of SWH predictions.
SAB-YOLOv5: An Improved YOLOv5 Model for Permanent Magnetic Ferrite Magnet Rotor Detection
Authors: Yu Bo , Li Qi , Jiao Wenhua , Zhang Shiyang , Zhu Yongjun
Published: March 2024

Surface defects on the permanent magnetic ferrite magnet rotor are the primary cause for the decline in performance and safety hazards in permanent magnet motors. Machine-vision methods offer the possibility to identify defects automatically. In response to the challenges in the permanent magnetic ferrite magnet rotor, this study proposes an improved You Only Look Once (YOLO) algorithm named SAB-YOLOv5. Utilizing a line-scan camera, images capturing the complete surface of a general object are obtained, and a dataset containing surface defects is constructed. Simultaneously, an improved YOLOv5-based surface defect algorithm is introduced. Firstly, the algorithm enhances the capability to extract features at different scales by incorporating the Atrous Spatial Pyramid Pooling (ASPP) structure. Then, the fusion of features is improved by combining the tensor concatenation operation of the feature-melting network with the Bidirectional Feature Pyramid Network (BiFPN) structure. Finally, the introduction of the spatial pyramid dilated (SPD) convolutional structure into the backbone network and output end enhances the detection performance for minute defects on the target surface. In the study, the SAB-YOlOv5 algorithm shows an obvious increase from 84.2% to 98.3% in the mean average precision (mAP) compared to that of the original YOLOv5 algorithm. The results demonstrate that the data acquisition method and detection algorithm designed in this paper effectively enhance the efficiency of defect detection permanent magnetic ferrite magnet rotors.
3-Complex Symmetric and Complex Normal Weighted Composition Operators on the Weighted Bergman Spaces of the Half-Plane
Authors: Jiang Zhi-Jie
Published: March 2024

One of the aims of this paper is to characterize 3-complex symmetric weighted composition operators induced by three types of symbols on the weighted Bergman space of the right half-plane with the conjugation Jf(z)=f(z¯)¯. It is well known that the complex symmetry is equivalent to 2-complex symmetry for the weighted composition operators studied in the paper. However, the interesting fact that 3-complex symmetry is not equivalent to 2-complex symmetry for such operators is found in the paper. Finally, the complex normal of such operators on the weighted Bergman space of the right half-plane with the conjugation J is characterized.
Deciphering the Molecular Mechanisms of Reactive Metabolite Formation in the Mechanism-Based Inactivation of Cytochrome p450 1B1 by 8-Methoxypsoralen and Assessing the Driving Effect of phe268
Authors: Kamel Emadeldin M. , Alwaili Maha A. , Rudayni Hassan A. , Allam Ahmed A. , Lamsabhi Al Mokhtar
Published: March 2024

This study provides a comprehensive computational exploration of the inhibitory activity and metabolic pathways of 8-methoxypsoralen (8-MP), a furocoumarin derivative used for treating various skin disorders, on cytochrome P450 (P450). Employing quantum chemical DFT calculations, molecular docking, and molecular dynamics (MD) simulations analyses, the biotransformation mechanisms and the active site binding profile of 8-MP in CYP1B1 were investigated. Three plausible inactivation mechanisms were minutely scrutinized. Further analysis explored the formation of reactive metabolites in subsequent P450 metabolic processes, including covalent adduct formation through nucleophilic addition to the epoxide, 8-MP epoxide hydrolysis, and non-CYP-catalyzed epoxide ring opening. Special attention was paid to the catalytic effect of residue Phe268 on the mechanism-based inactivation (MBI) of P450 by 8-MP. Energetic profiles and facilitating conditions revealed a slight preference for the C4′=C5′ epoxidation pathway, while recognizing a potential kinetic competition with the 8-OMe demethylation pathway due to comparable energy demands. The formation of covalent adducts via nucleophilic addition, particularly by phenylalanine, and the generation of potentially harmful reactive metabolites through autocatalyzed ring cleavage are likely to contribute significantly to P450 metabolism of 8-MP. Our findings highlight the key role of Phe268 in retaining 8-MP within the active site of CYP1B1, thereby facilitating initial oxygen addition transition states. This research offers crucial molecular-level insights that may guide the early stages of drug discovery and risk assessment related to the use of 8-MP.
Tetramethylpyrazine Antagonizes the Subchronic Cadmium Exposure-Induced Oxidative Damage in Mouse Livers via the Nrf2/HO-1 Pathway
Authors: Hu Xue , Zhao Siqi , Guo Ziming , Zhu Yiling , Zhang Shuai , Li Danqin , Shu Gang
Published: March 2024

Hepatic oxidative stress is an important mechanism of Cd-induced hepatotoxicity, and it is ameliorated by TMP. However, this underlying mechanism remains to be elucidated. To investigate the mechanism of the protective effect of TMP on liver injuries in mice induced by subchronic cadmium exposure, 60 healthy male ICR mice were randomly divided into five groups of 12 mice each, namely, control (CON), Cd (2 mg/kg of CdCl2), Cd + 100 mg/kg of TMP, Cd + 150 mg/kg of TMP, and Cd + 200 mg/kg of TMP, and were acclimatized and fed for 7 d. The five groups of mice were gavaged for 28 consecutive days with a maximum dose of 0.2 mL/10 g/day. Except for the control group, all groups were given fluoride (35 mg/kg) by an intraperitoneal injection on the last day of the experiment. The results of this study show that compared with the Cd group, TMP attenuated CdCl2-induced pathological changes in the liver and improved the ultrastructure of liver cells, and TMP significantly decreased the MDA level (p < 0.05) and increased the levels of T-AOC, T-SOD, and GSH (p < 0.05). The results of mRNA detection show that TMP significantly increased the levels of Nrf2 in the liver compared with the Cd group as well as the HO-1 and mRNA expression levels in the liver (p < 0.05). In conclusion, TMP could inhibit oxidative stress and attenuate Cd group-induced liver injuries by activating the Nrf2 pathway.
Identification and Biological Evaluation of a Novel Small-Molecule Inhibitor of Ricin Toxin
Authors: Yang Xinran , Wei Aili , Cao Xiyuan , Wang Zicheng , Wan Hongzhi , Wang Bo , Peng Hui
Published: March 2024

The plant-derived toxin ricin is classified as a type 2 ribosome-inactivating protein (RIP) and currently lacks effective clinical antidotes. The toxicity of ricin is mainly due to its ricin toxin A chain (RTA), which has become an important target for drug development. Previous studies have identified two essential binding pockets in the active site of RTA, but most existing inhibitors only target one of these pockets. In this study, we used computer-aided virtual screening to identify a compound called RSMI-29, which potentially interacts with both active pockets of RTA. We found that RSMI-29 can directly bind to RTA and effectively attenuate protein synthesis inhibition and rRNA depurination induced by RTA or ricin, thereby inhibiting their cytotoxic effects on cells in vitro. Moreover, RSMI-29 significantly reduced ricin-mediated damage to the liver, spleen, intestine, and lungs in mice, demonstrating its detoxification effect against ricin in vivo. RSMI-29 also exhibited excellent drug-like properties, featuring a typical structural moiety of known sulfonamides and barbiturates. These findings suggest that RSMI-29 is a novel small-molecule inhibitor that specifically targets ricin toxin A chain, providing a potential therapeutic option for ricin intoxication.
Sonocatalytic Activity of Porous Carbonaceous Materials for the Selective Oxidation of 4-Hydroxy-3,5-dimethoxybenzyl Alcohol
Authors: Hashemi Hosseini Behdokht , Oliveira Rafael L. , Łomot Dariusz , Chernyayeva Olga , Colmenares Quintero Juan C.
Published: March 2024

Selective oxidation, which is crucial in diverse chemical industries, transforms harmful chemicals into valuable compounds. Heterogeneous sonocatalysis, an emerging sustainable approach, urges in-depth exploration. In this work, we investigated N-doped or non-doped carbonaceous materials as alternatives to scarce, economically sensitive metal-based catalysts. Having synthesized diverse carbons using a hard-template technique, we subjected them to sonication at frequencies of 22, 100, 500, and 800 kHz with a 50% amplitude. Sonochemical reaction catalytic tests considerably increased the catalytic activity of C-meso (non-doped mesoporous carbon material). The scavenger test showed a radical formation when this catalyst was used. N-doped carbons did not show adequate and consistent sonoactivity for the selective oxidation of 4-Hydroxy-3,5 dimethoxybenzyl alcohol in comparison with control conditions without sonication, which might be associated with an acid–base interaction between the catalysts and the substrate and sonoactivity prohibition by piridinic nitrogen in N-doped catalysts.
Design, Synthesis, Computational Studies, and Anti-Proliferative Evaluation of Novel Ethacrynic Acid Derivatives Containing Nitrogen Heterocycle, Urea, and Thiourea Moieties as Anticancer Agents
Authors: El Abbouchi Abdelmoula , Mkhayar Khaoula , Elkhattabi Souad , El Brahmi Nabil , Hiebel Marie-Aude , Bignon Jérôme , Guillaumet Gérald , Suzenet Franck , El Kazzouli Saïd
Published: March 2024

In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported. The synthesised compounds were screened for their anti-proliferative activity against two different cancer cell lines, namely, HL60 (promyelocytic leukaemia) and HCT116 (human colon carcinoma). The results of the in vitro tests reveal that compounds 1–3, 10, 16(a–c), and 17 exhibit potent anti-proliferative activity against the HL60 cell line, with values of the percentage of cell viability ranging from 20 to 35% at 1 μM of the drug and IC50 values between 2.37 μM and 0.86 μM. Compounds 2 and 10 showed a very interesting anti-proliferative activity of 28 and 48% at 1 μM, respectively, against HCT116. Two PyTAP-based fluorescent EA analogues were also synthesised and tested, showing good anti-proliferative activity. A test on the drug-likeness properties in silico of all the synthetised compounds was performed in order to understand the mechanism of action of the most active compounds. A molecular docking study was conducted on two human proteins, namely, glutathione S-transferase P1-1 (pdb:2GSS) and caspase-3 (pdb:4AU8) as target enzymes. The docking results show that compounds 2 and 3 exhibit significant binding modes with these enzymes. This finding provides a potential strategy towards developing anticancer agents, and most of the synthesised and newly designed compounds show good drug-like properties.
Cytotoxic Cyclolignans Obtained by the Enlargement of the Cyclolignan Skeleton of Podophyllic Aldehyde, a Selective Podophyllotoxin-Derived Cyclolignan
Authors: García Pablo A. , Hernández Ángela-Patricia , Gómez-Zurita Mª Antonia , Miguel del Corral José M. , Gordaliza Marina , Francesch Andrés , San Feliciano Arturo , Castro Mª Ángeles
Published: March 2024

Podophyllotoxin, a cyclolignan natural product, has been the object of extensive chemomodulation to obtain better chemotherapeutic agents. Among the obtained podophyllotoxin derivatives, podophyllic aldehyde showed very interesting potency and selectivity against several tumoral cell lines, so it became our lead compound for further modifications, as described in this work, oriented toward the enlargement of the cyclolignan skeleton. Thus, modifications performed at the aldehyde function included nucleophilic addition reactions and the incorporation of the aldehyde carbon into several five-membered rings, such as thiazolidinones and benzo-fused azoles. The synthesized derivatives were evaluated against several types of cancer cells, and although some compounds were cytotoxic at the nanomolar range, most of them were less potent and less selective than the parent compound podophyllic aldehyde, with the most potent being those having the lactone ring of podophyllotoxin. In silico ADME evaluation predicted good druggability for most of them. The results indicate that the γ-lactone ring is important for potency, while the α,β-unsaturated aldehyde is necessary to induce selectivity in these cyclolignans.
Novel Enzyme-Assisted Recycle Amplification Strategy for Tetracycline Detection Based on Oxidized Single-Walled Carbon Nanohorns
Authors: Feng Tingting , Yan Shuzhu , Huang Yu
Published: March 2024

In this study, oxidized single-walled carbon nanohorns (oxSWCNHs) were prepared using nitric acid oxidation and subsequently combined with 3′6-carboxyfluorescein through charge transfer to prepare fluorescent probes. These oxSWCNHs were used to quench fluorogen signals at short distances and dissociate ssDNA using cryonase enzymes. We established a method for rapidly detecting tetracycline (TC) in complex samples based on the amplification of cryonase enzyme signals. After optimizing the experimental conditions, our method showed a detection limit of 5.05 ng/mL, with good specificity. This method was used to determine the TC content in complex samples, yielding a recovery rate of 90.0–103.3%. This result validated the efficacy of our method in detecting TC content within complex samples.
One-Step Hydrothermal/Solvothermal Preparation of Pt/TiO2: An Efficient Catalyst for Biobutanol Oxidation at Room Temperature
Authors: Lei Lijun , Cao Qianyue , Ma Jiachen , Hou Fengxiao
Published: March 2024

The selective oxidation of biobutanol to prepare butyric acid is an important conversion process, but the preparation of low-temperature and efficient catalysts for butanol oxidation is currently a bottleneck problem. In this work, we prepared Pt-TiO2 catalysts with different Pt particle sizes using a simple one-step hydrothermal/solvothermal method. Transmission electron microscopy and X-ray diffraction results showed that the average size of the Pt particles ranged from 1.1 nm to 8.7 nm. Among them, Pt-TiO2 with an average particle size of 3.6 nm exhibited the best catalytic performance for biobutanol. It was capable of almost completely converting butanol, even at room temperature (30 °C), with a 98.9% biobutanol conversion, 98.4% butyric acid selectivity, and a turnover frequency (TOF) of 36 h−1. Increasing the reaction temperature to 80 and 90 °C, the corresponding TOFs increased rapidly to 355 and 619 h−1. The relationship between the electronic structure of Pt and its oxidative performance suggests that the synergistic effect of the dual sites, Pt0 and Pt2+, could be the primary factor contributing to its elevated reactivity.
Cyclocurcumin as Promising Bioactive Natural Compound: An Overview
Authors: Gasbarri Carla , Angelini Guido
Published: March 2024

Although identical in molecular formula and weight, curcumin and cyclocurcumin show remarkable differences in their reactivity. Both are natural compounds isolated from the rhizome of turmeric, the former is involved in the diketo/keto-enol tautomerism through the bis-α,β-unsaturated diketone unit according to the polarity of the solvent, while the latter could react by trans-cis isomerization due to the presence of the α,β-unsaturated dihydropyranone moiety. Even if curcumin is generally considered responsible of the therapeutical properties of Curcuma longa L. due to its high content, cyclocurcumin has attracted great interest over the last several decades for its individual behavior and specific features as a bioactive compound. Cyclocurcumin has a hydrophobic nature characterized by fluorescence emission, solvatochromism, and the tendency to form spherical fluorescent aggregates in aqueous solution. Molecular docking analysis reveals the potentiality of cyclocurcumin as antioxidant, enzyme inhibitor, and antiviral agent. Promising biological activities are observed especially in the treatment of degenerative and cardiovascular diseases. Despite the versatility emerging from the data reported herein, the use of cyclocurcumin seems to remain limited in clinical applications mainly because of its low solubility and bioavailability.
Acylated Inulin as a Potential Shale Hydration Inhibitor in Water Based Drilling Fluids for Wellbore Stabilization
Authors: Lv Kaihe , Shen Haokun , Sun Jinsheng , Huang Xianbin , Du Hongyan
Published: March 2024

Shale hydration dispersion and swelling are primary causes of wellbore instability in oil and gas reservoir exploration. In this study, inulin, a fructo-oligosaccharide extracted from Jerusalem artichoke roots, was modified by acylation with three acyl chlorides, and the products (C10-, C12-, and C14-inulin) were investigated for their use as novel shale hydration inhibitors. The inhibition properties were evaluated through the shale cuttings hot-rolling dispersion test, the sodium-based bentonite hydration test, and capillary suction. The three acylated inulins exhibited superb hydration-inhibiting performance at low concentrations, compared to the commonly used inhibitors of KCl and poly (ester amine). An inhibition mechanism was proposed based on surface tension measurements, contact angle measurements, Fourier-transform infrared analysis, and scanning electron microscopy. The acylated inulin reduced the water surface tension significantly, thus, retarding the invasion of water into the shale formation. Then, the acylated inulin was adsorbed onto the shale surface by hydrogen bonding to form a compact, sealed, hydrophobic membrane. Furthermore, the acylated inulins are non-toxic and biodegradable, which meet the increasingly stringent environmental regulations in this field. This method might provide a new avenue for developing high-performance and ecofriendly shale hydration inhibitors.
A Study of the Drift Phenomena of Gate-Functionalized Biosensors and Dual-Gate-Functionalized Biosensors in Human Serum
Authors: Song Yunjia , Chen Nan , Curk Tine , Katz Howard E.
Published: March 2024

In this paper, we study the drift behavior of organic electrochemical transistor (OECT) biosensors in a phosphate-buffered saline (PBS) buffer solution and human serum. Theoretical and experimental methods are illustrated in this paper to understand the origin of the drift phenomenon and the mechanism of ion diffusion in the sensing layer. The drift phenomenon is explained using a first-order kinetic model of ion adsorption into the gate material and shows very good agreement with experimental data on drift in OECTs. We show that the temporal current drift can be largely mitigated using a dual-gate OECT architecture and that dual-gate-based biosensors can increase the accuracy and sensitivity of immuno-biosensors compared to a standard single-gate design. Specific binding can be detected at a relatively low limit of detection, even in human serum.
The Preparation and Performance Study of Polyamide Film Based on PDA@MWCNTs/PVDF Porous Support Layer
Authors: Xu Zhenzhen , Li Quanjun , Sun Xuzhi , Xing Jian , Hong Xinghua , Liu Feng
Published: March 2024

It is urgent to develop a polyamide (PA) thin-film composite (TFC) membrane with a new method in this study by designing and constructing a new nanomaterial support layer instead of the conventional support layer. Polydopamine-wrapped single-walled carbon nanotubes (PDA@MWCNTs) as the place of the polymerization reaction can optimize the PA film structure and performance. The resulting composite membrane presents a higher water flux of 15.8 L·m−2·h−1·bar−1 and a rejection rate of 97% to Na2SO4, simultaneously maintaining this high separation performance in 300 min. It is a new ideal to construct novel support layer by using inorganic nanoparticles and organic polymer nanofiber membranes.
An Electrochemical Immunosensor Based on Chitosan–Graphene Nanosheets for Aflatoxin B1 Detection in Corn
Authors: Zhang Shuai , Wu Caizhang , Zhao Zhike , Xu Kun
Published: March 2024

We reported a highly efficient electrochemical immunosensor utilizing chitosan–graphene nanosheets (CS-GNs) nanocomposites for the detection of aflatoxin B1 (AFB1) in corn samples. The CS-GNs nanocomposites, serving as a modifying layer, provide a significant specific surface area and biocompatibility, thereby enhancing both the electron transfer rate and the efficiency of antibody immobilization. The electrochemical characterization was conducted utilizing both differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). Moreover, the antibody concentration, pH, antibody immobilization time, and immunoreaction time, were optimized. The results showed that the current change (ΔI) before and after the immunoreaction demonstrated a strong linear relationship (R2=0.990) with the AFB1 concentration, as well as good specificity and stability. The linear range extended from 0.05 to 25 ng/mL, with a detection limit of 0.021 ng/mL (S/N=3). The immunosensor exhibited a recovery rate ranging from 97.3% to 101.4% in corn samples, showing a promising performance using an efficient method, and indicating a remarkable prospect for the detection of fungal toxins in grains.
Nanomaterial Delivery Vehicles for the Development of Neoantigen Tumor Vaccines for Personalized Treatment
Authors: Huang Xiaoyu , Zhu Xiaolong , Yang Huan , Li Qinyi , Gai Lizhi , Sui Xinbing , Lu Hua , Feng Jiao
Published: March 2024

Tumor vaccines have been considered a promising therapeutic approach for treating cancer in recent years. With the development of sequencing technologies, tumor vaccines based on neoantigens or genomes specifically expressed in tumor cells, mainly in the form of peptides, nucleic acids, and dendritic cells, are beginning to receive widespread attention. Therefore, in this review, we have introduced different forms of neoantigen vaccines and discussed the development of these vaccines in treating cancer. Furthermore, neoantigen vaccines are influenced by factors such as antigen stability, weak immunogenicity, and biosafety in addition to sequencing technology. Hence, the biological nanomaterials, polymeric nanomaterials, inorganic nanomaterials, etc., used as vaccine carriers are principally summarized here, which may contribute to the design of neoantigen vaccines for improved stability and better efficacy.
A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton)
Authors: Sugitha S. K. Johnsy , Venkatesan Raja , Latha R. Gladis , Vetcher Alexandre A. , Al-Asbahi Bandar Ali , Kim Seong-Cheol
Published: March 2024

The green synthesis of zinc oxide nanoparticles (ZnO NPs) using plants has grown in significance in recent years. ZnO NPs were synthesized in this work via a chemical precipitation method with Jasminum sambac (JS) leaf extract serving as a capping agent. These NPs were characterized using UV-vis spectroscopy, FT-IR, XRD, SEM, TEM, TGA, and DTA. The results from UV-vis and FT-IR confirmed the band gap energies (3.37 eV and 3.50 eV) and the presence of the following functional groups: CN, OH, C=O, and NH. A spherical structure and an average grain size of 26 nm were confirmed via XRD. The size and surface morphology of the ZnO NPs were confirmed through the use of SEM analysis. According to the TEM images, the ZnO NPs had an average mean size of 26 nm and were spherical in shape. The TGA curve indicated that the weight loss starts at 100 °C, rising to 900 °C, as a result of the evaporation of water molecules. An exothermic peak was seen during the DTA analysis at 480 °C. Effective antibacterial activity was found at 7.32 ± 0.44 mm in Gram-positive bacteria (S. aureus) and at 15.54 ± 0.031 mm in Gram-negative (E. coli) bacteria against the ZnO NPs. Antispasmodic activity: the 0.3 mL/mL sample solution demonstrated significant reductions in stimulant effects induced by histamine (at a concentration of 1 µg/mL) by (78.19%), acetylcholine (at a concentration of 1 µM) by (67.57%), and nicotine (at a concentration of 2 µg/mL) by (84.35%). The antipyretic activity was identified using the specific Shodhan vidhi method, and their anti-inflammatory properties were effectively evaluated with a denaturation test. A 0.3 mL/mL sample solution demonstrated significant reductions in stimulant effects induced by histamine (at a concentration of 1 µg/mL) by 78.19%, acetylcholine (at a concentration of 1 µM) by 67.57%, and nicotine (at a concentration of 2 µg/mL) by 84.35%. These results underscore the sample solution’s potential as an effective therapeutic agent, showcasing its notable antispasmodic activity. Among the administered doses, the 150 mg/kg sample dose exhibited the most potent antipyretic effects. The anti-inflammatory activity of the synthesized NPs showed a remarkable inhibition percentage of (97.14 ± 0.005) at higher concentrations (250 µg/mL). Furthermore, a cytotoxic effect was noted when the biologically synthesized ZnO NPs were introduced to treated cells.
Radical Mediated Decarboxylation of Amino Acids via Photochemical Carbonyl Sulfide (COS) Elimination
Authors: Benny Alby , Di Simo Lorenzo , Guazzelli Lorenzo , Scanlan Eoin M.
Published: March 2024

Herein, we present the first examples of amino acid decarboxylation via photochemically activated carbonyl sulfide (COS) elimination of the corresponding thioacids. This method offers a mild approach for the decarboxylation of amino acids, furnishing N-alkyl amino derivatives. The methodology was compatible with amino acids displaying both polar and hydrophobic sidechains and was tolerant towards widely used amino acid-protecting groups. The compatibility of the reaction with continuous-flow conditions demonstrates the scalability of the process.
Proclamation and Power: Toward a Phenomenology of Preaching and Its Affects
Authors: McLaughlin-Sheasby Amy
Published: March 2024

Preachers have long perceived that the power of proclamation can only partially be traced to sermonic language. Something is always stirring beneath the surface of our words—a sublinguistic property of preaching tugs at the attention and responses of our hearers. Many homileticians affirm that preaching is empowered by the Spirit. God gives preaching its efficacy, sometimes despite our language. We frequently describe effective preaching as anointed, evoking the distinctly divine quality of preaching. But preaching—like scripture, the sacraments, and the incarnation—is a mysterious union of the divine and the human, the Creator and the created. This essay focuses on a creaturely aspect of preaching, namely, the way it awakens, conjures, transmits, and configures emotion. The divine cannot be parsed from the experiencing body; however, affect theory offers insight into creaturely emotional interplay that elucidates what happens in preaching and how. This essay follows the lead of affect theorists who contend that activities such as preaching are always inherently affective, and that affects contribute to the structuring of social power. Attention to the emotional experiences of bodies in preaching offers a mode by which a phenomenology of social power in preaching may emerge.
Théorie et pratique des lacs en Italie. Normes, fonctions et cas paradigmatiques
Authors: Fanetti Stefano , Muti Giuseppe , Vaccari Ezio
Published: March 2024

Partendo dall’analisi dei laghi naturali e artificiali italiani, il contributo affronta la carenza strutturale di dati per evidenziare gli squilibri tra le funzioni dei bacini lacustri e la loro regolazione e tutela giuridica. Studiando casi paradigmatici sulla gestione dei laghi dal punto di vista dell’inquinamento industriale e della costruzione e gestione delle infrastrutture pubbliche, si evidenzia una costante distanza tra la narrazione dei laghi come elemento naturale fondamentale, oggetto di pratiche e politiche di tutela, e la pratica attuale dei laghi come oggetto di sfruttamento contraddittorio in ambito economico e politico.
La trajectoire touristique des lacs de Savoie : apports des documents promotionnels dans l’analyse de l’évolution de lieux touristiques
Authors: Jobert Chloé , Duval-Massaloux Mélanie
Published: March 2024

This article presents a research carried out in 2016 within the framework of a Master’s degree in geography at the University of Savoie Mont Blanc, which focused on the concept of tourist image of the lakes of Savoie. Regarding the latest bi-departmental promotional tourism campaign focused on lake tourism, it proposes to take a retrospective and analytical look at the lake tourism development in the department of Savoie, with the lakes of Bourget and Aiguebelette. To do so, the article mobilizes the chronosystemic tool in order to cross the images produced by the stakeholders of the destination and the lake planning actions. Three main tourist periods are thus defined, with several «types » of lakes interspersed. Their perspective highlights both i) permanences in the images produced, with “ types of lakes” continuously mobilized by tourism stakeholders to sell their destination but also ii) innovations with the creation of new discursive elements. In fine, this work highlights the logic of permanent readjustments between the tourism images produced by the stakeholders of tourism promotion, the main developments carried out and the tourism practices observed.
Biblijski sloj hrvatskoglagoljskih propovijedi na primjeru Senjskoga korizmenjaka (1508.)
Authors: Radošević Andrea , Kuhar Kristijan , Požar Sandra
Published: March 2024

U radu se istražuje biblijski sloj u Senjskom korizmenjaku (1508.), jedinoj tiskanoj glagoljskoj zbirci propovijedi koja predstavlja hrvatski prijevod djela Quaresimale volgare Roberta Caracciola iz Lecce. Naglasak je stavljen na utvrđivanje različitih stupnjeva oslanjanja citata na već postojeće prijevode biblijskih čitanja, za razliku od nekih prijašnjih istraživanja, u kojima je zanimanje bilo usmjereno na ispitivanje stupnja prilagođenosti biblijskih dijelova ostatku propovjednog teksta. Biblijski citati uspoređuju se s hrvatskoglagoljskim knjigama (misalima, brevijarima, psaltirima) u kojima je sačuvano više od polovice crkvenoslavenskoga prijevoda Svetoga pisma te s latiničnim lekcionarima. Cilj je rada istražiti jesu li crkvenoslavenizmi uglavnom rezultat prevoditeljeva stilskog obilježavanja teksta (oznaka višeg registra) ili pak potvrda oslanjanja na liturgijske predloške. Analizom suodnosa čakavskih i crkvenoslavenskih dijelova citata donose se zaključci o postojanju svojevrsne prevoditeljske koncepcije intelektualaca koji su na prijelazu iz 15. u 16. stoljeće sudjelovali u radu senjske glagoljske tiskare.
The Intentional Layering of Love, Imagination, and Expression as a Pathway to Freedom: A Conversation with Drs. Detra Price and Yolanda Sealey-Ruiz
Authors: Touloukian Cami , Price Detra , Sealey-Ruiz Yolanda
Published: March 2024

This conversation was first imagined as an interview with Drs. Detra Price and Yolanda Sealey-Ruiz about their groundbreaking book Advancing Racial Literacies in Teacher Education: Activism for Equity in Digital Spaces. With a focus on fostering and learning from students' digital activism by purposefully weaving together pedagogies for racial justice and multimodal literacies, their book and their scholarship is the perfect fit for this special issue. However, much like their book that recently won the Divergent Publication Award, these two scholars and visionaries are not easily boxed in. Thus, while our conversation begins by exploring how arts and technologies can come together to promote healing, we also delve into the intentional layering of love, imagination, (un)learning, artistic expression, amplification, and trusting relationships as essential components for building the world we want to live in.
Testbed mimicking intracellular environment for optical-resolution photoacoustic microscopy
Authors: Nishimae Daisuke , Ishii Takuro , Ogasawara Kouetsu , Saijo Yoshifumi
Published: March 2024

Photoacoustic imaging (PAI) represents an innovative method that utilizes optics for transmission and acoustic for sensing. Within the realm of PAI modalities, optical-resolution photoacoustic microscopy (OR-PAM) stands out for its ability to achieve high-resolution cellular and intracellular imaging. However, an optical testbed setup emulating the intracellular environment and accelerating the development of cellular-level OR-PAM systems has not been established. In this study, we present a testbed setup designed to mimic intracellular conditions. Assessment of this testbed setup efficacy involved embedding photoacoustic contrasts and imaging them using an OR-PAM system. The imaging results show that our testbed setup can provide instrumental in accurately measuring photoacoustic signals within an intracellular aqueous environment, avoiding risks of the contamination and degradation of the acoustic transducer.
Optical analysis of III-nitride micro-light-emitting diodes with different sidewall treatments at low current density operation
Authors: Wong Matthew S. , Gee Stephen , Tak Tanay , Gandrothula Srinivas , Rebollo Steve , Cha NamGoo , Speck James S. , DenBaars Steven P.
Published: March 2024

In this work, the optical efficiency of III-nitride blue micro-LEDs (μLEDs) ranged from 5 × 5 to 60 × 60 μm2 with different sidewall treatments at low current density range was investigated. The results showed dielectric sidewall passivation using atomic layer deposition (ALD) has superior optical enhancement compared to conventional RF sputtering, where most of the enhancement occurred at low current density range. Additionally, the use of ALD sidewall passivation and chemical treatment offered significant efficiency improvement for different sizes of μLEDs at operating less than 1 A cm−2 and the devices without sidewall treatments did not emit light. The effect of sidewall treatments to the effective Shockley–Read–Hall (SRH) nonradiative recombination coefficient, or the effective A coefficient from the ABC model, was estimated. The effective SRH nonradiative recombination coefficient was suppressed by two orders of magnitude for devices with sidewall treatments compared to devices without sidewall passivation.
Compared RGB Methods Towards Efficient Money Detector for Blind People
Authors: Fadilah Maulina , Maulana Yulian Zetta , YUSRO MUHAMMAD
Published: March 2024

Limitations of profound visual impairment distinguishing each nominal number of banknotes are often used by people with bad intentions to take advantage of that basis, like money fraud. Due to this reason, the blind people need to be helped to recognize their surroundings by developing assistive technology that is advanced for them. This study aims to build an efficient design of a money detector by comparing three RGB methods: range breakdown, If-Then Rules, and decision tree to recognize the nominal of money. The sample used in this experiment is rupiah banknotes for the 2016 and 2022 issuances. The device is built with a TCS3200 colour sensor and designed in a real-time platform. It has been found that the highest average percentage accuracy was achieved by the breakdown range method with 100% (2016 sample) and 90% (2022 sample). This device also successfully produced a notification sound from a speaker that mentions the detected nominal value. This research could be used as a reference to improve assistive technology for blind people.
ВИЗНАЧЕННЯ СТАТИЧНОГО МОМЕНТУ ЕЛЕКТРОДВИГУНА В АВТОМАТИЗОВАНОМУ ЕЛЕКТРОПРИВОДІ
Authors: Соколовський Юлій , Лимонов Леонід
Published: March 2024

Точна інформація про величину статичного моменту навантаження електродвигуна, що діє у складі автоматизованого електроприводу, використовується як для підвищення технологічних показників, так і захисту електродвигуна та механізму в аварійних ситуаціях.
TECHNOLOGICAL AND TACTICAL SUBSYSTEMS OF THE INTELLIGENT MANAGEMENT INFORMATION SYSTEM (ON THE EXAMPLE OF AN OIL AND GAS CORPORATION)
Authors: Krasnyuk Maxim , Kulynych Yurii , Hrashchenko Iryna , Krasniuk Svitlana , Goncharenko Svitlana , Denysenko Vitalina
Published: March 2024

Providing Ukraine with its own oil and natural gas is one of the main tasks of the national economy. The possibility of development of the oil and gas industry is primarily determined by the volume of explored and mined resources. Since the existing explored reserves will not ensure the growth of oil and gas production, it is necessary to increase the amount of investments in the exploration and development of new deposits and hydrocarbon deposits with the aim of increasing their reserves and further growth of production, which requires the adoption of management decisions, which are characterized by increased technological and economic risk, uncertainty.

Taking into account the main reasons for the decline in oil and gas production in Ukraine, the specifics of the industry and the requirements for information systems in the oil and gas industry, it can be argued that the use of intelligent technologies not only at the strategic, but also at the tactical and technological levels of management - is one of the keys to success in creating/reengineering, implementation and effective use of management decision support systems.

The scientific and practical results presented in the article regarding the innovative configurations of architecture and  design, proposed intellectual methodology for tactical and technological subsystems of the corporation management information systems. The above-proposed solutions - should be taken into account when reengineering corporate information systems not only in the oil and gas industry in Ukraine [1-3].

Moreover, the obtained results are relevant and applicable not only for local companies, but also for international corporations on emerging markets in the context of global and regional macroeconomic and military crisis phenomena.
ОСОБЛИВОСТІ ВИКОРИСТАННЯ КЕЙС-ТЕХНОЛОГІЇ В УМОВАХ ІННОВАЦІЙНОЇ ПАРАДИГМИ ОСВІТИ
Authors: Вишківська Ванда , Голікова Оксана
Published: March 2024

Стан вищої освіти в Україні в умовах модернізації вимагає забезпечення сучасної якості знань. Головна зміна у суспільстві, що впливає на ситуацію у сфері освіти, - прискорення темпів розвитку суспільства. Парадигма розвитку сучасного суспільства спрямована на розширення функції освіти як соціокультурного феномену, як одного з найважливіших факторів соціальної стабільності, культури, виховання особистості креативної, мобільної, відповідальної, підготовки фахівців, які вміють досягати поставленої мети в різних освітніх ситуаціях за рахунок володіння методами вирішення широкого кола професійних завдань, готових здійснювати інноваційну діяльність.
ФОРМУВАННЯ ЗДОРОВОГО СПОСОБУ ЖИТТЯ СПЕЦІАЛІСТІВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ В СУЧАСНИХ УМОВАХ НАВЧАННЯ НА ПРИКЛАДІ ЗАГАРТУВАННЯ
Authors: Шепеленко Тетяна , Дорофєєва Тетяна , Гринько Віталій , Сапегіна Ірина , Довженко Світлана
Published: March 2024

Для професійної підготовки студентів фізична культура має велике значення. Відомо, що здорова, фізично підготовлена людина, яка має великий арсенал різноманітних вмінь та навичок, зможе швидше адаптуватися до майбутньої професійної діяльності та умов виробництва, більш ефективно працювати. Незважаючи на збільшення частки розумової праці в сучасному виробництві, фізична підготовленість працівників не втрачає своєї актуальності, так як сприяє підвищенню не тільки фізичної, але й розумової працездатності, допомагає більш ефективно боротися з наслідками втоми та нервово-психічної напруги. В своїй основі фізична культура має доцільну рухову діяльність в формі фізичних вправ, завдяки чому відбувається формування важливих  вмінь та навичок, фізичних здібностей, підвищення рівня здоров’я і працездатності.
ГОЛОКОСТ В ХАРКОВІ: ДИСКУРС КУЛЬТУРИ ПАМ’ЯТІ
Authors: Фесенко Галина
Published: March 2024

У статті на основі існуючої історіографії окреслено події, що передували Голокосту в Харкові, доля євреїв в часи німецької окупації, перші спроби радянсьої влади зафіксувати злочини у Дробицькому ярі. Висвітлено контекст змін в публічній радянській політиці у напрямку «неєврейськості» жертв Дробицького Яру та «неділення мертвих». Це згодом вплинула на немеморіалізацію масових могил у Дробицькому яру у радянський період.
EVALUATION OF ANTERIOR SEGMENT CHANGES AFTER LASER PERIPHERAL IRIDOTOMY AND TRABECULECTOMY IN PRIMARY ANGLE CLOSURE GLAUCOMA USING SIRIUS SCHEIMPFLUG IMAGING
Authors: Mahendra Dhara , Kumar Manoj
Published: March 2024

Purpose: To evaluate changes in anterior segment morphology following laser peripheral iridotomy (LPI) and trabeculectomy in primary angle
closure glaucoma (PACG) using Sirius Scheimpug imaging. Methods: In this prospective study, PACG patients undergoing LPI and
trabeculectomy were imaged pre- and post-procedure using the Sirius Scheimpug system. Anterior segment parameters including anterior
chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), iris curvature (I-Curv), and lens vault (LV) were analyzed
and compared. Results: 72 eyes of 36 PACG patients were analyzed. At 1 month post-LPI, there was signicant widening of ACA (p<0.001),
attening of I-Curv (p=0.002), and lowering of LV (p<0.001) with no change in ACD or ACV. After trabeculectomy, ACD and ACV increased
signicantly (p<0.001), along with further ACA widening (p=0.03) and I-Curv attening (p=0.01). LV remained reduced. Conclusions: Sirius
imaging allows quantitative assessment of anterior segment changes after LPI and trabeculectomy in PACG. LPI induced morphologic changes
consistent with iris prole attening and angle widening. Trabeculectomy additionally increased anterior chamber depth and volume. Scheimpug
imaging enables understanding of biomechanical effects of glaucoma surgery.
Pyramid of Thought: Enhancing the Chain of Thought with the Fibonacci Sequence and the Inner Thought Journal
Authors: Fabo Nkwindjeu
Published: March 2024

Recent advances in large language models (LLMs) have demonstrated their
remarkable abilities in complex language tasks. However, achieving the
depth and flexibility of human reasoning remains a challenge. Inspired
by the power of step-by-step reasoning highlighted in “Chain-of-Thought
Prompting Elicits Reasoning in Large Language Models,” this paper
introduces the “Pyramid of Thought” framework. This framework
leverages principles of Euclidean geometry, the Fibonacci sequence, and
psychological engagement to create structured, adaptable AI responses
while promoting transparent and intuitive communication.

The “Pyramid of Thought” uses a dynamic layer mechanism, adjustable
via  linear, logarithmic, or Fibonacci-based scaling.  This aligns the
AI’s thought process with natural mathematical patterns. Mirroring
psychological principles, this approach aims to promote user
engagement.  Each layer builds on the previous one, starting with
foundational facts (“Five Ws”) and progressing through reasoning steps
(“How,” “Then”), culminating in an “Apex” of analysis or insight.
An inner thought journal maintains contextual richness.

The flexible and iterative nature of the “Pyramid of Thought” reflects
the emphasis on refinement and evolution found in conceptual modeling.
Experiments will evaluate its effectiveness against traditional AI
response methods. Metrics will include user engagement, response
coherence, satisfaction, and the model’s ability to communicate its
reasoning process transparently. We anticipate that the “Pyramid of
Thought” will produce more intuitive, meaningful, and thought-provoking
interactions, aligning with the goals of conceptual modeling in
simulation. This work contributes to the development of AI systems that
better emulate human reasoning patterns and foster clearer
communication.
In ricordo del Professore Alberto Abrami
Authors: Manni Cristiano
Published: March 2024

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