bluuebunny/crossref_metadata_2025 huggingface dataset:
Historiografia e historicidade de mulheres militares profissionais da saúde no planejamento reprodutivo
Authors: Elias Elayne Arantes , Paiva Andyara do Carmo Pinto Coelho , Souza Ívis Emília de Oliveira
Published: March 2023

Objetivos: descrever a historiografia e a historicidade de mulheres militares profissionais de saúde do Corpo de Bombeiros Militar do Estado do Rio de Janeiro no vivido do planejamento reprodutivo. Metodologia: Pesquisa qualitativa com abordagem fenomenológica heideggeriana. Participaram 21 mulheres militares das equipes de saúde que realizam o atendimento pré-hospitalar, da coordenação dessas equipes, de uma policlínica e uma odontoclínica. Foram realizadas entrevistas gravadas, fidedignamente transcritas e lidas de forma atentiva. Resultados: A maioria das mulheres tem filhos, não vive com um companheiro e também possui vida sexual ativa. Todas já utilizaram algum método contraceptivo e o mais citado foi a pílula anticoncepcional. A maioria afirmou que realiza o planejamento reprodutivo nos relatos de decisão de ter filhos e evidenciando o momento de não utilizar os métodos contraceptivos para a concretização da maternidade. Em contrapartida, a gravidez não planejada também foi desvelada, gerando insatisfação em algumas. As mulheres devem ser assistidas por profissionais qualificados para que o planejamento reprodutivo, de fato, seja exercido efetivamente, incluindo os homens no processo. Conclusão: O planejamento reprodutivo deve ser aplicado e estimulado pelos profissionais de saúde e discutido na sua amplitude de ações, cumprindo com as políticas públicas de saúde e os princípios do SUS. O enfermeiro deve realizar a abordagem da saúde sexual e reprodutiva o quanto antes, através da educação em saúde e do respeito aos direitos sexuais e reprodutivos.
Synthesis, characterization, and evaluation of derivatives from cardanol as repellents/pesticides agents of Liriomyza sativae (Diptera: Agromyzidae) and Bemisia tabaci (Hemiptera: Aleyrodidae) on melon plants
Authors: Oliveira Maria Roniele Félix , Dias-Pini Nívia da Silva , Celin Elaine Facco , Abreu Katiany do Vale , Oliveira Nádylla Régis Xavier de , Melo Airis Maria Araújo , Oliveira Marília de Albuquerque , Biswas Atanu , Cheng Huai Nan , Alves Carlucio Roberto
Published: March 2023

Hydrogenated cardanol derivatives were evaluated as potentially active insecticides/repellent agents against insect pests such as Liriomyza sativae (Diptera: Agromyzidae) and Bemisia tabaci biotype B (Hemiptera: Aleyrodidae). Benzoylation, acetylation, and methylation were made on the hydrogenated cardanol aromatic ring to synthesize active ingredients with potential insecticide action. Nuclear magnetic resonance spectra (13C and 1H NMR) and infrared (IR) proposed the chemical elucidation of the products. The production of melon seedlings was made and each synthesized products, benzoylated 3-pentadecylphenol, acetylated 3-pentadecylphenol, and methylated 3-pentadecylphenol were applied to seedlings by glass sprayer. Phytotoxicity evaluations were carried out, noting that all the plants showed burnt leaves except for concentration of 1% which the leaves remained healthy look. The insecticidal efficacy as well as the repellent and dissuasive effects were evaluated by a completely randomized design (DIC) and a randomized complete block design (DBCA) with six treatments, five and four replicates respectively. The compounds derived from cardanol did not present insecticidal activity in DBCA for L. sativae; however, they had a noticeable effect on oviposition index (IPO). Ovicidal effect and nymphal mortality only were found for B. tabaci by methylated 3-pentadecylphenol and Mospilan® in terms of dissuasion and oviposition effects in the two bioassays evaluated and, methylated 3-pentadecyl showed a similar behavior as the effect of Abamectin® on the confinement test, with 53.5% - 65.4% repellence of adults, an important data to emphasize that the products synthesized from cardanol are promising in preventing the pests attack such as L. sativae and, B. tabaci.
Tratamento conservador da polpa em dentes permanentes vitais com rizogênese incompleta – uma revisão de literatura
Authors: Veras Pedryna Maria Oliveira , Oliveira Daisy Coelho , Rodrigues Jéssica da Silva , Paiva Leyriane Mendes , Costa Marinna Barroso Maciel , Cunha Clarice Fernandes Eloy da Costa , Vivacqua Flávia Darius
Published: March 2023

O objetivo deste estudo foi realizar uma revisão de literatura acerca dos tratamentos conservadores propostos para os casos de dentes permanentes jovens, com rizogênese incompleta e vitalidade pulpar, bem como os materiais mais utilizados para este fim. Trata-se de uma revisão integrativa da literatura. Os estudos foram criteriosamente avaliados e coletados através de buscas nas plataformas de pesquisa da Pubmed, Scielo, BVS e Google Scholar, utilizando os seguintes termos: “Conservative Treatment”, “Pulp Capping” e “Endodontics”. Após a busca nos portais eletrônicos foram encontrados 67 artigos no qual foi realizada a leitura de títulos e resumos, respeitando os critérios de inclusão e exclusão, elegendo-se assim, 43 estudos para análise detalhada. Após a avaliação do texto completo, excluíram-se 22, restando 21 artigos que compuseram   esta revisão. As técnicas atualmente descritas na literatura para este fim são: o capeamento pulpar direto, curetagem pulpar e pulpotomia, sendo os principais materiais utilizados para a realização desses procedimentos o Hidróxido de Cálcio e o Agregado de Trióxido Mineral (MTA). Os estudos mostram não haver diferença significativa entre ambos, com relação a resposta pulpar e a continuidade da formação apical. Conclui-se que o capeamento pulpar direto é o procedimento atualmente mais realizado e viável em casos de dente permanente jovem, com ápice incompleto. Dentre os materiais de escolha, os mais utilizados para esse procedimento são o hidróxido de cálcio e o MTA, contudo o MTA, tem apresentado propriedades biológicas mais relevantes.
Benefícios da Análise do Comportamento Aplicada para Intervenção Precoce no Transtorno do Espectro Autista (TEA)
Authors: Cavalcante Suyane Santana , Costa Flávia Beatriz Piauilino , Rocha Yloma Fernanda de Oliveira , Correia Rodrigo Feitosa de Oliveira , Lustosa Geovanna Mirella Palmer , Viana Nilara Cardoso Pereira
Published: March 2023

O presente estudo busca refletir acerca da temática da importância e benefícios da Análise do Comportamento Aplicada (ABA) na intervenção precoce de crianças com o diagnóstico de Transtorno do Espectro Autista. A intervenção precoce baseada nos princípios da ABA pode melhorar o funcionamento de crianças com TEA, abordando déficits e excessos comportamentais. Deste modo, o objetivo dessa obra busca compreender a atuação do método ABA no auxílio e desenvolvimento de crianças que vivem no espectro. Trata-se de uma revisão integrativa de literatura como método de investigação sobre o tema, uma vez que esse modelo de pesquisa busca organizar e examinar os discursos e contribuições realizadas por outros autores. Os dados coletados obtiveram-se a partir das bases de dados: Scientific Electronic Library Online, Literatura Latino-Americana em Ciências da saúde via BVS e Medical Literature and Retrivial System on-Line via PubMed, período de 2017 até 2022. Obteve-se uma amostra de oito estudos, os resultados apresentaram deduções positivas com relação à relevância da Análise do Comportamento Aplicada e a possibilidade do desenvolvimento de mais habilidades cognitivas, comportamentais e sociais, a partir do diagnóstico e intervenção precoce.
Obstrução intraluminal de duodeno proximal em dois animais do gênero Ateles spp - Relato de caso
Authors: Baselly-Cueva Luis Orlando , Cestari Heitor , Gallo Caroline de Cássia , Moraes Alessandra Regina Dhom Pimentel de , Souza Estevam Rodriguez de , Janini Ludimila Cardoso Zoccal , Oba Eunice
Published: March 2023

A obstrução intestinal por corpo estranho de origem frutífera em primatas não humanos é pouco comum na rotina clínico cirúrgica de animais silvestres, mas de grande relevância quando se trata de animais resgatados que foram submetidos a mudanças alimentares, podendo ocasionar ingestão errônea de frutos inteiros e de sementes de grande tamanho. Desta forma, o objetivo deste trabalho é relatar dois animais do gênero Ateles spp. que apresentaram desconforto abdominal agudo e que foram submetidos à celiotomia exploratória onde observou-se obstrução intraluminal por corpo estranho de origem frutífera do duodeno proximal, ambos os casos foram submetidos ao tratamento cirúrgico e manejo pós-operatório. Observou-se melhora clínica de ambos os animais e foi possível o retorno dos mesmos ao centro de resgate e concluiu-se que a técnica empregada de diagnóstico, tratamento e manejo pós-operatório foi eficiente para a manutenção da vida destes animais.
Pseudomeningocele Iatrogênica: Uma revisão de literatura
Authors: Silva Laura Ramires , Pessoa Caroline Pimentel , Torres-da-Silva Kelly Regina , Machado Alex Martins , Machado Aline Rafaela da Silva Rodrigues , Silva André Valério da
Published: March 2023

Introdução: Pseudomeningocele iatrogênica consiste na laceração do saco dural resultando em vazamento do líquido cerebroespinhal (LCR) durante cirurgia da coluna vertebral, como reparo para hérnia de disco. Trata-se de um cisto revestido por tecido fibroso e preenchido por LCR, sendo sintomático ou assintomático. Nesse sentido, deve-se ressaltar essa complicação cirúrgica com grandes prejuízos ao paciente, como sintomas álgicos no pós-cirúrgico. Objetivo: Revisão narrativa acerca da literatura publicada sobre o assunto buscando reunir e sintetizar o conhecimento. Método: revisão de literatura com pesquisas nas bases de dados Biblioteca Virtual em Saúde/MEDLINE, CINAHL, Web of Science e Scopus CAPES, com os descritores do Medical Subject Headings (MeSH): “pseudomeningocele”, “adult”, “laminectomy'', associados pelo operador booleano AND, no período 2005 a 2021. Foram encontrados 92 artigos, sendo 14 duplicados e 5 triplicados. Dos 49 artigos encontrados, 18 foram incluídos, com o objeto de responder a partir da leitura na íntegra, à pergunta norteadora: “Quais as manifestações clínicas, diagnósticos e tratamentos utilizados para identificar, tratar e prever prognóstico para pacientes com pseudomeningocele?”. Resultados e discussão: os casos de pseudomeningocele é assintomática, pequena e regride espontaneamente. Em sintomáticos, manifesta-se por cefaléia, dor lombar e radiculopatia. Trata-se de fatores de risco: técnicas invasivas, uso de acetonido de triancinolona epidural, laminectomia e idade avançada, foraminectomia, abordagem lateral e fusão foram fatores protetivos. O tratamento para assintomáticos é conservador; sintomáticos, recomenda-se a revisão cirúrgica para reparo dural. Conclusão: Portanto, sua compreensão é importante para reduzir a ocorrência e conscientizar os pacientes sobre seu risco durante cirurgias da coluna vertebral.
Promoção da qualidade de vida para idosos por meio da inclusão digital: Projeto EnvelheSer
Authors: Landim Marcos Jonaty Rodrigues , Oliveira Evandro Nogueira de
Published: March 2023

A proporção de pessoas com mais de 60 anos no mundo aumentará para 1 em cada 6 pessoas até 2050, enquanto a expectativa de vida tem aumentado para 90% em países com maior expectativa de vida. A pandemia de COVID-19 revelou a urgência das questões relacionadas à longevidade. Durante o isolamento social, as tecnologias digitais tornaram-se grandes aliadas da população idosa, ajudando a minimizar a solidão dos idosos e oferecendo-lhes mais atenção e cuidado. A fase da velhice apresenta desafios únicos para os idosos, como a possibilidade de vida solitária, perda de entes queridos e falta de rede de apoio, que podem torná-los vulneráveis. A tecnologia pode ser uma ferramenta de ajuda, mas muitos idosos têm dificuldades para compreender e usar essas tecnologias, o que pode levar à desigualdade e ao isolamento. A falta de habilidade e acesso à tecnologia também pode limitar sua capacidade de manter contato com a sociedade de forma independente. Assim, este trabalho objetiva analisar e discutir alguns aspectos da aplicação do projeto EnvelheSer, um projeto que visa proporcionar a inclusão digital às pessoas idosas. Desse modo, foi visto que os idosos necessitam de mais oportunidades e que projetos como este necessitam ser progressivamente mais presentes na sociedade.
KINERJA DINAS KOMUNIKASI DAN INFORMATIKA KOTA PONTANAK DALAM PELAYANAN INFORMASI BERBASIS ELEKTRONIK JEPIN (JENDELA PONTIANAK INTEGRASI)
Authors: Ismail Ismail , Azizah Nur Laili
Published: March 2023

Jendela Pontianak Integrasi (JEPIN) is an electronic-based public information service system that is a product of the Pontianak City Communication and Informatics Office. JEPIN aims to be a forum for information about the needs of the community, the Pontianak city government, and community complaints. This research is based on the findings of obstacles experienced by the agency in the application of the system through secondary data. The purpose of this research is to find out the performance of the Pontianak City Communication and Informatics Office in organizing JEPIN information services. This research is qualitative descriptive research with inductive approach (from special to general) Interview, observation and documentation data collection techniques. Data analysis techniques used include data reduction, data presentation and conclusion drawing. The results of research at the Department of Communication and Informatics Pontianak city showed that the performance of the office in electronic-based information services is still not running well, this is seen from 5 (five) dimensions of the assessment of the performance of the office which 4 (four) of them did not meet the target that has been determined. Namely productivity, quality of service, responsiveness, and responsiveness, only the dimension of accountability meets the targeted service.

Keyword: Jendela Pontianak Integrasi (JEPIN), Performance, Information Services
EFEKTIVITAS PELAYANAN PENERBITAN KARTU KELUARGA MELALUI TANDA TANGAN ELEKTRONIK DI DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KOTA SOLOK PROVINSI SUMATERA BARAT
Authors: Rizqiqa Edtyva Dwirahmi , Amalia Rizki
Published: March 2023

Electronic signatures are an innovation of the population acceleration program, aimed at making population documents more efficient without having to meet face-to-face. There are still damaged documents in the issuance of family cards and the limited number of employees who understand services through electronic signatures are problems. The purpose of the study was to determine the effectiveness of family card issuance services through electronic signatures, obstacles and efforts to overcome them. The method used is descriptive qualitative inductive approach. Data collection techniques were carried out by triangulation which included in-depth interviews (10 informants), observation and documentation. In this paper, an analysis of the effectiveness of family card issuance services through electronic signatures is carried out with the indicators studied, namely (1) Production or productivity, (2) Quality, (3) Efficiency, (4) Flexibility, and (5) Satisfaction. (Gibson and Steers in Sumaryadi (2005:107)).The results showed that the effectiveness of family card issuance services through electronic signatures had been implemented quite well, but still needed improvements in efficiency indicators. Barriers to the effectiveness of family card issuance services through electronic signatures, namely (1) Unstable Network Connections, (2) Lack of Human Resources, (3) Lack of supporting facilities. Efforts are being made to overcome obstacles, namely (1) repairing the server network that is experiencing disruptions, (2) Involving existing employees in training or technical guidance, (3) Adding supporting facilities. Suggestions from the research: (1) reform the system related to optimizing the central network as the organizer of the Electronic Signature policy, (2) increase the number of employees and (3) improve infrastructure facilities.

Keywords: Electronic Signature, Effectiveness, Family Card.
Transformasi Pelayanan Dinas Kependudukan Dan Pencatatan Sipil Kabupaten Subang Di Masa Pandemi Covid 19
Authors: Mulianingsih Sunasih
Published: March 2023

Pelayanan aparatur sipil negara (ASN) kepada masyarakat, di masa pandemi covid 19, menghadapi berbagai permasalahan, meskipun demikian harus tetap berjalan sebagaimana mestinya, melalui perubahan dan penyempurnaan, agar masyarakat tetap mendapatkan pelayanan sesuai kebutuhannya. Tujuan penelitian ini adalah untuk mengetahui Transformasi Pelayanan Dinas Kependudukan dan Pencatatan Sipil Kabupaten Subang di masa Pandemi Covid 19 serta hambatan dan upaya mengatasi hambatan tersebut. Dalam penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan induktif. Data diperoleh dari primer dan sekunder. Hasil dan simpulan, bahwa Agar pelayanan dapat terlaksana dengan sebaik-baiknya, maka Dinas Kependudukan dan pencatan sipil melakukan perubahan atau Transformasi di bidang pelayanan meskipun pelaksanaannya terbatas karena memiliki hambatan yaitu Sarana yang belum memadai yang berupa jaringan, kemudian yang dimiliki oleh masyarakat untuk memperlancar transformasi pelayanan terbatas, selanjutnya mind set masyarakat masih sederhana dan Adanya keterbatasan SDM dalam proses transformasi secara kulaitas maupun kuantitas. untuk mengatasi hambatan dilakukan upaya sosialisasi dan edukasi, membuka mindset masyarakat dan Untuk keterbatasan sumber daya manusia melalui pendidikan dan latihan IT bagi pegawai.Kata Kunci: Transformasi; Pelayanan; Pandemi Covid-19.
Manajemen Pemerintahan Kecamatan Dalam Mendukung Penerapan Protokol Kesehatan Di Kecamatan Wirosari Kabupaten Grobogan
Authors: Setiawan Irfan
Published: March 2023

Penelitian ini bertujuan untuk mengkaji dan menganalisis manajemen pemerintahan kecamatan dalam mendukung penerapan protokol kesehatan pandemi Covid di Kecamatan Wirosari, dan untuk mengkaji dan mengetahui dukungan pemerintah daerah dalam penanganan pandemi Covid 19 di Kecamatan Wirosari, Kabupaten Grobogan, Jawa Tengah. Penelitian ini menggunakan konsep manajemen Terry (1971) untuk mendeskripsikan penyelenggaraan manajemen pemerintahan kecamatan. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Guna memperoleh informasi yang jelas, peneliti menggunakan teknik pengumplan data melalui wawancara, obeservasi dan dokumentasi terhadap sumber data yang berasal dari para aparat di Kantor Kecamatan Wirosari, pegawai Puskesmas, aparat instansi vertikal, lurah dan kepala desa desa serta masyarakat di Kecamatan Wirosari. Data Hasil penelitian menunjukkan Manajemen pemerintahan Kecamatan dalam mendukung penanganan protokol kesehatan di Kecamatan Wirosari berjalan dengan baik. Hal tersebut terlihat dari pelaksanaan fungsi perencanaan, pengorganisasian, pergerakan dan pengawasan di Kecamatan Wirosari.Dukungan pemerintah kabupaten berjalan dengan baik pada segi dukungan kebijakan, sementaraa untuk dukungan anggaran kegiatan tidak didukung secara khusus dengan anggaran dalam pelaksanaan kegiatan di kecamatan.Kata Kunci: Manajemen Pemerintahan; Kecamatan; Protokol kesehatan; Pandemi Covid.
Analisis Perilaku Korupsi Aparatur Pemerintah Di Indonesia (Studi pada Pengelolaan Bantuan Sosial Di Era Pandemi Covid-19)
Authors: Setiawan Irfan , Jesaja Christin Pratami
Published: March 2023

Korupsi merupakan suatu tindakan menyimpang untuk mendapatkan kekayaan dan keuntungan pribadi menggunakan uang rakyat atau negara secara ilegal dengan menyalahgunakan kekuasaan yang diberikan. Salah satu kasus yang terjadi belakangan ini dan cukup memprihatinkan ialah kasus korupsi bantuan sosial di masa pandemi virus corona. Tujuan penulisan ini adalah menganalisis perilaku korupsi bantuan sosial oleh para aparatur pemerintahan di tengah pandemi virus corona, Penanganan tindakan korupsi aparatur pemerintahan Indonesia, dan Upaya untuk meminimalisir tindakan korupsi bantuan social di Indonesia. Penelitian ini memadukan konsep Kast, Rosenzweig, 1970 mengenai perilaku yang didasarkan motivasi, konsep McClelland, 1985 mengenai dorongan dasar motivasi & konsep GONE dari Jack Bologne, 1993 mengenai penyebab korupsi. Metode penulisan yang digunakan adalah metode deskriptif dan kepustakaan (pengumpulan data pustaka) dengan melakukan analisis secara sistematis dari semua data terkumpul yang berkaitan dengan masalah dalam penulisan, disamping itu penulis juga mewawancarai tenaga ahli baik dari penyuluh anti korupsi maupun pengkaji masalah sumber daya aparatur. Hasil penulisan ini menunjukkan bahwa korupsi merupakan masalah yang sangat besar karena dapat mengganggu pertumbuhan dan pembangunan negara, serta butuh penanganan serius untuk mengatasi atau meminimalisir keberadaannya. Korupsi bisa terjadi karena cara pandang seseorang akan kekayaan yang salah, ketamakan, adanya peluang, kebutuhan, penyalahgunaan kekuasaan, tidak adanya nilai-nilai integritas dan nasionalisme, ketidaktegasan hukum, dan pandangan terhadap hukum. Salah satu contohnya ialah kasus korupsi penyalahgunaan dana bantuan sosial saat pandemi virus corona yang menyebabkan kerugian besar. Upaya yang dapat dilakukan untuk meminimalisir hal ini dapat dilakukan dengan memberi edukasi sejak dini akan nilai-nilai anti korupsi, menegakkan hukum yang berlaku secara tegas, dan menyosialisasikan kepada masyarakat tentang mekanisme pengaduan dan pelaporan apabila mengetahui terjadinya tindakan korupsi.

 

Kata Kunci: Perilaku Korupsi, Aparatur Pemerintah, Bantuan Sosial, Pandemi COVID-19
Research progress on antitumor activity of XRP44X and analogues as microtubule targeting agents
Authors: Wang Chao , Shi Lingyu , Yang Shanbo , Chang Jing , Liu Wenjing , Zeng Jun , Meng Jingsen , Zhang Renshuai , Xing Dongming
Published: March 2023

Cancer threatens human health and life. Therefore, it is particularly important to develop safe and effective antitumor drugs. Microtubules, the main component of cytoskeleton, play an important role in maintaining cell morphology, mitosis, and signal transduction, which are one of important targets of antitumor drug research and development. Colchicine binding site inhibitors have dual effects of inhibiting proliferation and destroying blood vessels. In recent years, a series of inhibitors targeting this target have been studied and some progress has been made. XRP44X has a novel structure and overcomes some disadvantages of traditional inhibitors. It is also a multifunctional molecule that regulates not only the function of tubulin but also a variety of biological pathways. Therefore, the structure, synthesis, structure-activity relationship, and biological activity of XRP44X analogues reported in recent years were summarized in this paper, to provide a useful reference for the rational design of efficient colchicine binding site inhibitors.
Using multiple lines of evidence to assess recovery potential of a warm water fish population in a cold water impacted river
Authors: Tonkin Zeb , Koehn John , Commens Sarah , Hackett Graeme , Harris Annique , Kitchingman Adrian , Lyon Jarod , Moloney Paul , Todd Charles , Woodhead Jon
Published: March 2023

Introduction

Humans have substantially altered landscapes across the globe, generating novel ecosystems with varying states of modification. The principles of reconciliation ecology emphasise that such novel ecosystems must also be considered for conservation outcomes. This requires an understanding of how anthropogenic habitat alterations in a novel ecosystem may disrupt life cycle processes of key biota, thereby enabling the development of management strategies that may bypass or ameliorate potential bottlenecks in life history stages. We explore this by assessing Murray cod (Maccullochella peelii), a native fish species of considerable cultural, recreational and conservation significance in a severely altered river reach in south-eastern Australia. This species was considered to have disappeared in the reach following alterations to the river’s thermal profile (cold water pollution - CWP), but instead has persisted.

Methods

We examined the life cycle of Murray cod and use multiple lines of evidence to assess the impacts of CWP pollution on key processes such as adult migration, recruitment and juvenile survival. We also evaluated the potential for recovery and persistence of the species in this novel system using mitigation measures such as flow management and stocking and opportunistically tested their effectiveness.

Results

We found the key impact pathway of CWP on the Murray cod population is via its effects on the key processes influencing natural recruitment. Conversely, the effects of CWP on emigration and survival of larger juveniles and adults did not appear to be a major bottleneck for the population. Using a stochastic population model, we showed that the population could be sustained by stocking and opportunistic water management while still meeting irrigation demands. Monitoring to test our recommendations showed natural recruitment and improved survival of stocked fish during years with limited flow releases, thereby corroborating our predictions.

Discussion

Our use of multiple lines of evidence to assess a species’ responses to impacts of habitat alteration in a novel ecosystem enabled the formulation of recommendations for management that could then be tested. The success of such actions add to the growing body of literature that shows species of conservation significance can be maintained in novel ecosystems which should be specifically considered within the context of conservation planning across the landscape.
Incremental healthcare cost burden in patients with atrial flutter only
Authors: Kim Kathryn M. , Kim Steven Y. , Schulman Kathy L. , Kim Michael H.
Published: March 2023

Background

Limited information is available on the costs related to atrial flutter only. This study provides a comprehensive estimate of the cost in patients with atrial flutter only versus matched patients without any atrial arrhythmia.

Methods

Patients over 20 years of age with a minimum of one inpatient or two outpatient diagnosis codes for atrial flutter in 2005 and a minimum of 12 months of continuous enrollment pre- and post-index were identified using the MarketScan Commercial and Medicare databases. Atrial flutter patients were propensity matched to patients without atrial arrhythmias. Total costs for each patient for 12 months post-index were calculated. National cost was estimated using the projected prevalence of atrial flutter for 2010.

Results

A total of 1,042 patients with atrial flutter only were successfully matched with comparison patients. For atrial flutter patients compared to matched controls without atrial arrhythmias, total mean annual cost per patient was 81% higher ($23,008 vs. $12,717) and mean annual inpatient expenditure was 214% higher ($8,518 vs. $2,713). When applied to national atrial flutter prevalence data, total incremental cost burden was estimated to be $687.9 million per year more than patients without atrial arrhythmias, primarily due to cardiovascular specific expenditure ($377 million, 55% of total) with 58% ($218.5 million) of the increased inpatient expenditure due to cardiovascular specific admissions and $159 million (23%) for atrial flutter specific care. Sex-related differences were also present in atrial flutter only patients.

Conclusion

Although atrial flutter-only patients are less prevalent than atrial fibrillation patients, the national incremental cost burden in atrial flutter is substantial on a per-patient level.
Examining the influence of substance use on mental health rating during COVID-19: A Canadian perspective
Authors: Sivashankar Yadurshana , Chen Ze Lin
Published: March 2023

Introduction

Substance use and mental health symptoms (e.g., depression and anxiety) have increased during the COVID-19 pandemic, partly due to implementation of physical distancing measures aimed at containing the spread of the SARS-CoV-2 virus. However, there is limited pandemic-specific research that has examined the relationship between substance use and mental health with other correlates of well-being, including life satisfaction and social confidants.

Methods

In the current study, we used ordered logistic regression analyses to examine whether a greater frequency of substance use (e.g., alcohol, cannabis, and opioids) during the pandemic predicted poorer ratings of self-reported mental health in a large sample of Canadians aged 15 to 64 years. We further considered whether life satisfaction and number of social confidants interacted with substance use to influence mental health, and stratified the models by sex and personal feelings of shame surrounding the use of substances (i.e., high and low shame).

Results

Findings indicated that frequency of substance use was significantly associated with increased odds of reporting poorer mental health for males and females exhibiting both low and high shame. In females reporting low shame, we found that as frequency of cannabis use increased, life satisfaction has a much greater positive association with mental health. Whereas, in females disclosing high shame, maintaining social relations was particularly important to benefit the mental health of current users of opioids, relative to past and non-users. No such interaction was found in males.

Discussion

Overall, the findings of the current study showed the negative mental health consequences of substance use during COVID-19 in a large Canadian sample, and most importantly revealed a critical sex difference in the way in which social determinants interact with substance use to influence mental health.
ACER2 forms a cold tumor microenvironment and predicts the molecular subtype in bladder cancer: Results from real-world cohorts
Authors: Liu Jinhui , Cheng Chunliang , Qi Tiezheng , Xiao Jiatong , Zhou Weimin , Deng Dingshan , Dai Yuanqing
Published: March 2023

Background: ACER2 is a critical gene regulating cancer cell growth and migration, whereas the immunological role of ACER2 in the tumor microenvironment (TME) is scarcely reported. Thus, we lucubrate the potential performance of ACER2 in bladder cancer (BLCA).

Methods: We initially compared ACER2 expressions in BLCA with normal urothelium tissues based on data gathered from the Cancer Genome Atlas (TCGA) and our Xiangya cohort. Subsequently, we systematically explored correlations between ACER2 with immunomodulators, anti-cancer immune cycles, tumor-infiltrating immune cells, immune checkpoints and the T-cell inflamed score (TIS) to further confirm its immunological role in BLCA TME. In addition, we performed ROC analysis to illustrate the accuracy of ACER2 in predicting BLCA molecular subtypes and explored the response to several cancer-related treatments. Finally, we validated results in an immunotherapy cohort and Xiangya cohort to ensure the stability of our study.

Results: Compared with normal urinary epithelium, ACER2 was significantly overexpressed in several cell lines and the tumor tissue of BLCA. ACER2 can contribute to the formation of non-inflamed BLCA TME supported by its negative correlations with immunomodulators, anti-cancer immune cycles, tumor-infiltrating immune cells, immune checkpoints and the TIS. Moreover, BLCA patients with high ACER2 expression were inclined to the luminal subtype, which were characterized by insensitivity to neoadjuvant chemotherapy, chemotherapy and radiotherapy but not to immunotherapy. Results in the IMvigor210 and Xiangya cohort were consistent.

Conclusion: ACER2 could accurately predict the TME and clinical outcomes for BLCA. It would be served as a promising target for precision treatment in the future.
Advances and Clinical Outcomes in Hodgkin Lymphoma in the Era of Novel Therapies
Authors: Paviglianiti Annalisa , Rampi Nicolò
Published: March 2023

Hodgkin lymphoma (HL) is traditionally considered one of the hematological malignancies with the highest rate of cure, ranging from 70 to 90% depending on the disease and patient features [...]
Special Issue “Biotechnological Application of Photosynthetic Bacteria”
Authors: Miyasaka Hitoshi
Published: March 2023

This Special Issue aims to contribute to the current knowledge in the field and promote the practical application of photosynthetic bacteria (PSB) biotechnology [...]
A Sulfur-Bridging Sulfonate-Modified Zinc(II) Phthalocyanine Nanoliposome Possessing Hybrid Type I and Type II Photoreactions with Efficient Photodynamic Anticancer Effects
Authors: Chen Zixuan , Zhao Yuan-Yuan , Li Li , Li Ziqing , Fu Shuwen , Xu Yihui , Zheng Bi-Yuan , Ke Meirong , Li Xingshu , Huang Jian-Dong
Published: March 2023

Phthalocyanines are potentially promising photosensitizers (PSs) for photodynamic therapy (PDT), but the inherent defects such as aggregation-caused quenching effects and non-specific toxicity severely hinder their further application in PDT. Herein, we synthesized two zinc(II) phthalocyanines (PcSA and PcOA) monosubstituted with a sulphonate group in the alpha position with “O bridge” and “S bridge” as bonds and prepared a liposomal nanophotosensitizer (PcSA@Lip) by thin-film hydration method to regulate the aggregation of PcSA in the aqueous solution and enhance its tumor targeting ability. PcSA@Lip exhibited highly efficient production of superoxide radical (O2∙−) and singlet oxygen (1O2) in water under light irradiation, which were 2.6-fold and 15.4-fold higher than those of free PcSA, respectively. Furthermore, PcSA@Lip was able to accumulate selectively in tumors after intravenous injection with the fluorescence intensity ratio of tumors to livers was 4.1:1. The significant tumor inhibition effects resulted in a 98% tumor inhibition rate after PcSA@Lip was injected intravenously at an ultra-low PcSA@Lip dose (0.8 nmol g−1 PcSA) and light dose (30 J cm−2). Therefore, the liposomal PcSA@Lip is a prospective nanophotosensitizer possessing hybrid type I and type II photoreactions with efficient photodynamic anticancer effects.
Generic Methods for Simultaneous Analysis of Four Direct Oral Anticoagulants in Human Plasma and Urine by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Authors: Ren Jian-Wei , Zheng Xin , Han Xiao-Hong
Published: March 2023

The new direct oral anticoagulants (DOACs) are increasingly used to treat and prevent thromboembolic disorders, and monitoring concentrations may be valuable in some special scenarios to prevent clinical adverse events. This study aimed to develop generic methods for the rapid and simultaneous analysis of four DOACs in human plasma and urine. Protein precipitation and one-step dilution were used to prepare the plasma and urine; the extracts were injected to ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for analysis. Chromatographic separation was performed on an Acquity™ UPLC BEH C18 column (2.1 × 50 mm, 1.7 μm) with gradient elution of 7 min. A triple quadrupole tandem mass spectrometer with an electrospray ionization source was employed to analyze DOACs in a positive ion mode. The methods showed great linearity in the plasma (1~500 ng/mL) and urine (10~10,000 ng/mL) for all analytes (R2 ≥ 0.99). The intra- and inter-day precision and accuracy were within acceptance criteria. The matrix effect and extraction recovery were 86.5~97.5% and 93.5~104.7% in the plasma, while 97.0~101.9% and 85.1~99.5% in the urine. The stability of samples during the routine preparation and storage were within the acceptance criteria of less than ±15%. The methods developed were accurate, reliable, and simple for the rapid and simultaneous measurement of four DOACs in human plasma and urine, and successfully applied to patients and subjects with DOACs therapy for anticoagulant activity assessment.
Peranan Audit Operasional dalam Pemeriksaan Sumber dan Penggunaan Dana pada PT. BPR Eka Prasetya Medan
Authors: Sinaga Liskauli , Abidin Zainal , Rosmaini Rosmaini
Published: March 2023

xThe purpose of this study was to determine the role of operational audit in examining sources and uses of funds at BPR Eka Prasetya Medan. The formulation of the problem in this study is "What is the role of the operational audit in examining the sources and use of funds at BPR Eka Prasetya"?. Auditing is "An examination that is carried out critically and systematically by an independent party, on the financial statements that have been prepared by management along with the accounting records and supporting evidence, with the aim of being able to provide an opinion regarding the fairness of the financial statements". BPR Eka Prasetya Medan, prepares a cash flow statement using the indirect method, in which this method reports cash flows prepared based on cash/bank. The method of preparing the statement of cash flows is indirectly prepared based on the income statement and balance sheet. changes in cash inflows (inflows) and cash outflows (outflows) as presented in cash flows in operating activities are as follows, in 2011 the value of Rp. 894,055,200, - while in 2012 it was Rp. 610,441,800,-. Changes in operating cash flow can be seen from 2011 to 2012 of (Rp. 283,610,400) the company's operating cash flow experienced a decrease or was negative. After doing a comparison between theory and practice regarding the role of operational audit in the source and use of funds on cash flow as a tool in increasing the effectiveness and efficiency of the company. This can also be seen from the procedures carried out by BPR Eka Prasetya in avoiding misappropriation of incoming and outgoing cash.
Pengaruh Promsi dan Kualitas Produk Terhadap Keputusan Pembelian pada pelanggan PT. Biosafe Medan
Authors: Geofansa Irene Nur , Syahrial Hery , Isnaniah Isnaniah
Published: March 2023

The study purposes to identify : 1) the effect of promotion has a positive and significant influence towards the customer’s Buying Decision at PT. Biosafe Medan. 2) the effect of product quality has a positive and significant influence towards the customer’s Buying Decision at PT. Biosafe Medan. 3) the effect of both promotion and product quality has a simultaneous influence towards the customer’s Buying Ddecision at PT. Biosafe Medan. An associative study was conducted using population size as much as 26,275 employees. A total 100 respondents of PT. Biosafe Medan were chosen as the sampel by using random samplig method.  The  study  utilized the multiple linier regression  analysis as the data analysing technique. The dta of this study were gathered through interview and distributing questionnaire.  The  study  result  obtained  that  promotion  has  a  positif  and  significant influence towards the customer’s buying decision, where positive showed from the value 0,516 dan significant 0,000 0,05. Product quality has a positif dan significan influence towerds the customer’s buying decision, where positive showed prome the value 0,392 and significant 0,000 0,05. Both promotion and product quality has a positive and significant influence toweds the customer’s buying decision, where positif showed frome the value 2,711 and significant 0,000 0,05.
Podcasts na Educação Ambiental: o que apontam as pesquisas
Authors: Sant'Anna Murilo , Kárita Bonzanini Taitiâny
Published: March 2023

Realizou-se um levantamento sistemático em quatro bases de dados com o objetivo de identificar publicações dos últimos cinco anos que tratassem sobre o potencial do uso de podcasts como ferramenta para a Educação Ambiental, em especial, com discussões sobre gestão da água. Foram identificados 228 trabalhos que evidenciaram potencialidades dos podcasts em aproximar-se de audiências mais jovens, promovendo uma compreensão crítica sobre questões ambientais. Além disso, esse recurso pode favorecer aprendizagens com o uso da tecnicidade do jornalismo nos processos educativos, o que corrobora com a percepção de jornalismo educador.
"Abordagem Nexo - Alimento, Energia e Água" como contexto para o planejamento de práticas sustentáveis
Authors: Lourenço Ariane Baffa , Dictoro Vinicius Perez , Anício Sabrina de Oliveira , Borges Andréa , Fernandez Fernanda da Rocha Brando , Malheiros Tadeu Fabricio
Published: March 2023

Este artigo apresenta o Projeto Nexo - Alimento, Energia e Água desenvolvido na Universidade de São Paulo e direcionado ao ensino interdisciplinar em cursos de graduação a partir do planejamento de práticas sustentáveis em instituições extramuros da universidade. O Projeto tem como base o desenvolvimento de práticas que visem a abordagem do Nexo na resolução de problemas ambientais, e é realizado por discentes de diferentes cursos de graduação que trabalham em grupos em temas de sustentabilidade. Para além das práticas propostas e seus benefícios à sociedade, os resultados revelam que o Projeto tem potencial de promover oportunidades de aprendizagens dos discentes em uma perspectiva interdisciplinar.
Educação Ambiental: práticas pedagógicas em escolas da rede PEA da Unesco localizadas na Região Metropolitana de Campinas (SP)
Authors: Sartori Siliane Vanessa , Conti Diego de Melo , Sugahara Cibele Roberta , Benedicto Samuel Carvalho de
Published: March 2023

Nesta pesquisa, buscou-se verificar quais as práticas pedagógicas de Educação Ambiental são desenvolvidas em escolas integrantes da Rede Programa de Escolas Associadas da UNESCO localizadas na Região Metropolitana de Campinas/SP e se elas estão alinhadas com a Educação Ambiental para o desenvolvimento sustentável ou com a Educação Ambiental crítica. Quanto a metodologia o estudo é de natureza pura, exploratória com uma abordagem qualitativa. As técnicas utilizadas para a coleta dos dados desta pesquisa são a análise documental e bibliográfica. Assim, é possível concluir que as escolas estão preocupadas e buscando soluções para tratar os temais ambientais em sala de aula, mas ainda falta uma maior interação das escolas junto à comunidade, aos órgãos públicos na busca de uma Educação Ambiental que realmente seja efetiva e traga resultados concretos para as escolas e para a comunidade local.
Jogos sérios em sustentabilidade: uma análise exploratória nas plataformas GAMES4SUSTAINABILITY e LUDOPÉDIA
Authors: Georges Marcos Ricardo Rosa , Araújo Keila Santos
Published: March 2023

Os jogos sérios são assim chamados porquê são destinados à educação e treinamento de assuntos específicos. Nesta perspectiva, este trabalho analisou 154 jogos sérios disponíveis nas plataformas Games4Ssustainability e Ludopedia à luz da Sustentabilidade. Os resultados mostraram que o ODS 11 foi o assunto mais abordado, estando presente em 80 jogos, seguido pelo ODS 16 que foi abordado por 52 jogos. A maioria dos jogos (52) tratam de um único ODS, mas há 37 jogos que abordam simultaneamente 2 ODS’s e 25 jogos que abordam simultaneamente 3 ODS’s. A maioria dos jogos (53%) são de acesso pago, enquanto que 47% são de acesso livre.
Projeto “Ser Sustentável”: aprendizagem em educação climática das jornadas pelo clima no The Climate Reality Project Brasil
Authors: Cardoso Lilian
Published: March 2023

O The Climate Reality Project Brasil incentiva metodologias para a educação climática. O objetivo deste trabalho é apresentar o projeto Ser Sustentável elaborado por meio, das Jornadas pelo Clima, onde propõe ensinar que a crise climática pode ser reduzida através de um processo de Educação Ambiental que facilite a compreensão do agir ecológico como ferramenta de mudança. O projeto iniciou-se com publicação de fotografias de biodiversidade, plantio de mudas, coleta de tampinhas de plástico, compostagem caseira e hábitos ecológicos. Conclui-se que a propagação de ações mais sustentáveis norteia a reflexão e a busca de mudanças de atitudes e um maior entendimento sobre a realidade das consequências das mudanças climáticas globais.
Jogos de regras com embalagem cartonada na pedagogia
Authors: Magnani Eliana Maria , Sorbara Alessandra , Oselame Ana Carolina Severo , Wiederkehr Luana
Published: March 2023

Este texto tem por objetivo refletir acerca da Educação Ambiental, a partir da utilização de jogos educativos feitos com embalagens cartonadas e adaptados de modelos industrializados, tais como o Risk, o Lançando História e o Cachola. No estudo, explicita-se como os materiais foram explorados com acadêmicos do curso de Pedagogia da Universidade Estadual do Oeste do Paraná (Unioeste), campus de Cascavel (PR). O trabalho com os jogos apoiou-se em conteúdos da Proposta Curricular desse município, provocando inquietações relacionadas ao consumismo desenfreado e a outros temas relativos ao meio ambiente. Defende-se, desse modo, a implantação de uma (eco)brinquedoteca no curso de Pedagogia - um local lúdico que proporciona educação de qualidade.
Interacción de factores genéticos y ambientales en el metabolismo del ácido fólico y la patogénesis de defectos del tubo neural
Authors: Valdez Milton Alexander Morocho , Pozo-Palacios Juan
Published: March 2023

Los defectos del tubo neural (DTN) son considerados las malformaciones congénitas multifactoriales más frecuentes y comunes en humanos que afecta el desarrollo del sistema nervioso central, de los cuales presentan una mayor incidencia la espina bífida y la anencefalia. La estrategia preventiva de estos defectos congénitos es el consumo de ácido fólico; sin embargo, el efecto preventivo de esta vitamina esencial varía de acuerdo a la interacción entre factores genéticos y ambientales a la que se encuentre expuesto el feto. Además, las condiciones metabólicas maternas permiten una interacción materno-fetal perjudicial para el feto, que aumenta el riesgo de desarrollar estos defectos congénitos. El objetivo principal de esta investigación es describir la interacción de factores genéticos y ambientales implicados en el metabolismo del ácido fólico y la patogenia de DNT. Se espera impulsar el desarrollo de métodos que permitan diferenciar con mayor claridad los factores de susceptibilidad que contribuyen a la etiología de los DNT.
Assistência odontológica para pacientes com paralisia cerebral: uma revisão integrativa da literatura
Authors: De Farias Maria José Batista , De Queiroz José Thomas Azevedo , Farias Weslen Dhouglas da Silva , de Andrade Ana Carolina Soares , Do Nascimento Talita Álvares , De Mendonça Rayza Dayane Silva , Silva Lauralice Tavares , De Freitas Elyabe Erik Martins , Getar Brenda Vitória Silva , Ferreira Dayanne Larissa , Spineli Elizabete Arruda
Published: March 2023

Paralisia Cerebral (PC), é uma doença crônica que não tem cura, trata-se de uma das deficiências mais comuns na infância, e é caracterizada por alterações neurológicas permanentes que afetam o desenvolvimento motor e cognitivo, envolvendo o movimento e a postura do corpo e pode impossibilitar as crianças de algumas formas. A grande maioria dos pacientes portadores de paralisia cerebral não possui capacidade de realizar a higienização bucal adequadamente. Os índices elevados mostram que há prevalência da doença periodontal e cárie, relacionado com a dificuldade de higienização bucal e a presença da respiração bucal. O atendimento odontológico desse grupo populacional deve priorizar pela multidisciplinaridade, buscando em Odontologia a promoção de saúde bucal. o objetivo deste trabalho foi abordar sobre a assistência odontológica adequada a pacientes com paralisia cerebral. Trata-se de uma revisão integrativa da literatura, onde foram utilizados termos de pesquisa como "Paralisia Cerebral" e "Assistência Odontológica”, com filtros temporais dos último 6 anos e idiomas Português e Inglês. Foi possível elucidar as características e descrever sobre os pacientes com PC, classificando os tipos de sintomas, sinais e suas principais características. O trabalho relatou que estes pacientes são mais suscetíveis a apresentar alterações bucais e, em virtude disso, o profissional da Odontologia desempenha um papel necessário na equipe multiprofissional e em seu atendimento.