bluuebunny/crossref_metadata_2025 huggingface dataset:
Distance Learning Design: A Problem-Based Learning with Flipped Classroom Model through improving student learning outcomes and learning motivation
Authors: Laswadi Laswadi , Setiawan M Eval , Efyanti Yasni , Pentang Jupeth Toriano , Taresh Sahar M
Published: February 2024

The purpose of this study is to improve learning outcomes in the form of cognitive abilities and student learning motivation through the development of the learning design Problem-Based Learning within flipped classroom model. The study used quasi-experimental research with One Group Pretest-Post Test Design. In the research process, instruments are needed in the form of (1) multiple-choice tests as instructional cognitive measurements of students, and (2) observation sheets of learning motivation measurements in the form of motivational rubrics developed based on arcs rubrics. The increased motivation was analyzed based on the results of the questionnaire produced based on the ARCS rubric develop the results of student learning (post-test) are calculated using the t-test and then continued with the conclusion of the learning hypothesis. Based on the hypothesis test, it was found that 0.000 0.005, it can be concluded that there is a real difference between learning outcomes in the pretest and posttest data. This result means that the application of this learning method can improve the learning outcomes of students. In addition, there is an increase in motivation in the learning process with flipped classrooms and problem-based learning design. Increased student motivation in the learning process I to learning III by 3% to 13%. But from this study, it is expected that there will be further research using the same model in other subjects and by using a larger sample and taking measurements on affective and psychomotor aspects
B5N10 Nanocarrier Functionalized with Al, C, Si Atoms: A Drug Delivery Method for Infectious Disease Remedy
Authors: Mollaamin Fatemeh , Monajjemi Majid
Published: February 2024

As proof has recommended a close connection between COVID-19 and neurodegenerative disorders, this article aims to investigate the chloroquine (CLQ) drug as the SARS-CoV-2’s primary protease, which can prevent in vitro viral duplication of all diverse experiments to present. CLQ is an anti-viral drug enlarged by Pfizer, which can operate as an orally effective 3C-like protease inhibitor. In this study, CLQ has been assessed for its effectiveness against coronavirus by trapping it within a boron nitride nanocage (B5N10_NC) functionalized with specific atoms for drug delivery. This procedure relies on the principle of direct electron transfer and can be elucidated using density functional theory (DFT) in quantum mechanics methods. It was performed the theoretical method of the B3LYP/6-311+G(d,p) to account for the aptitude of B5N10_NC for grabbing CLQ drug via density of electronic states, nuclear quadrupole resonance, nuclear magnetic resonance, and thermodynamic specifications. Finally, the resulting amounts illustrated that using B5N10_NC functionalized with aluminum (Al), carbon (C), and silicon (Si) for adsorbing CLQ drug towards formation of CLQ@Al–B4N10_NC, CLQ@C–B4N10_NC, CLQ@Si–B4N10_NC might provide the reasonable formula in drug delivery technique which can be fulfilled by quantum mechanics computations due to physicochemical properties of PDOS, NMR, NQR, and IR spectrum. An overview of recent developments in nanocage-based drug delivery systems will be provided, including the design of nanocages and atom-doped nanocages.
Effectiveness of eHealth Interventions Promoting Physical Activity in Children and Adolescents: Systematic Review and Meta-Analysis
Authors: Sequí-Domínguez Irene , Cavero-Redondo Iván , Álvarez-Bueno Celia , López-Gil Jose Francisco , Martínez-Vizcaíno Vicente , Pascual-Morena Carlos
Published: February 2024

Background

eHealth interventions have been postulated as a feasible, acceptable, and possibly effective tool to promote physical activity (PA) among children and adolescents; however, a comprehensive quantitative analysis of the effects of eHealth interventions promoting PA is lacking.

Objective

This study aims to conduct a systematic review and meta-analysis on experimental studies reporting the effects of eHealth interventions aimed at promoting PA on PA parameters and sedentary behavior parameters in children and adolescents.

Methods

The CENTRAL, MEDLINE, Embase, and Web of Science databases were searched from inception to February 2022 for randomized controlled trials that analyzed the effects of eHealth interventions aimed at promoting PA on PA and sedentary parameters in children and adolescents. The Hartung-Knapp-Sidik-Jonkman random effects method was used to determine the mean differences (MDs) with their respective 95% CIs. The risk of bias was assessed using the Risk of Bias 2 (RoB2; Cochrane) tool and its extension for cluster randomized controlled trials. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool.

Results

A total of 20 trials reporting the effects of different eHealth interventions aimed at promoting PA were included. Results for each parameter were as follows: counts per minute (MD −16.11 counts, 95% CI −122.76 to 90.53; k=3; n=402; I2=69%; favoring control), steps per day (MD 593.46 steps, 95% CI −2102.27 to 3289.19; k=2; n=152; I2=0%; favoring intervention [FI]), moderate to vigorous PA (MD −1.99 min/d, 95% CI −8.95 to 4.96; k=14; n=2336; I2=86%; favoring control), light PA (MD 3.28 min/d, 95% CI −15.48 to 22.04; k=5; n=355; I2=67%; FI), screen time (MD −31.48 min/d, 95% CI −68.62 to 5.65; k=5; n=904; I2=0%; FI), and sedentary time (MD −33.12 min/d, 95% CI −57.27 to −8.97; k=8; n=819; I2=75%; FI). Our results should be interpreted cautiously because of important limitations such as the scarcity of evidence, overall risk of bias, and low to very low certainty of evidence.

Conclusions

We did not find conclusive evidence regarding the impact of PA-targeted eHealth interventions on PA parameters, but the very low certainty of evidence suggests that eHealth interventions may reduce sedentary time in children and adolescents. Our results may have important scientific implications as they highlight that the rapid development of eHealth interventions to promote PA lacks robust supporting evidence.

Trial Registration

PROSPERO CRD42020211020; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=211020
N-of-1 Trials of Antimicrobial Stewardship Interventions to Optimize Antibiotic Prescribing for Upper Respiratory Tract Infection in Emergency Departments: Protocol for a Quasi-Experimental Study
Authors: Attal Hersh , Huang Zhilian , Kuan Win Sen , Weng Yanyi , Tan Hann Yee , Seow Eillyne , Peng Li Lee , Lim Hoon Chin , Chow Angela
Published: February 2024

Background

Antimicrobial stewardship programs attempting to optimize antibiotic therapy and clinical outcomes mainly focus on inpatient and outpatient settings. The lack of antimicrobial stewardship program studies in the emergency department (ED) represents a gap in tackling the problem of antimicrobial resistance as EDs treat a substantial number of upper respiratory tract infection cases throughout the year.

Objective

We intend to implement two evidence-based interventions: (1) patient education and (2) providing physician feedback on their prescribing rates. We will incorporate evidence from a literature review and contextualizing the interventions based on findings from a local qualitative study.

Methods

Our study uses a quasi-experimental design to evaluate the effects of interventions over time in the EDs of 4 public hospitals in Singapore. We will include an initial control period of 18 months. In the next 6 months, we will randomize 2 EDs to receive 1 intervention (ie, patient education) and the other 2 EDs to receive the alternative intervention (ie, physician feedback). All EDs will receive the second intervention in the subsequent 6 months on top of the ongoing intervention. Data will be collected for another 6 months to assess the persistence of the intervention effects. The information leaflets will be handed to patients at the EDs before they consult with the physician, while feedback to individual physicians by senior doctors is in the form of electronic text messages. The feedback will contain the physicians’ antibiotic prescribing rate compared with the departments’ overall antibiotic prescribing rate and a bite-size message on good antibiotic prescribing practices.

Results

We will analyze the data using segmented regression with difference-in-difference estimation to account for concurrent cluster comparisons.

Conclusions

Our proposed study assesses the effectiveness of evidence-based, context-specific interventions to optimize antibiotic prescribing in EDs. These interventions are aligned with Singapore’s national effort to tackle antimicrobial resistance and can be scaled up if successful.

Trial Registration

ClinicalTrials.gov NCT05451863; https://clinicaltrials.gov/study/NCT05451836

International Registered Report Identifier (IRRID)

DERR1-10.2196/50417
Effectiveness of eHealth Interventions Promoting Physical Activity in Children and Adolescents: Systematic Review and Meta-Analysis (Preprint)
Authors: Sequí-Domínguez Irene , Cavero-Redondo Iván , Álvarez-Bueno Celia , López-Gil Jose Francisco , Martínez-Vizcaíno Vicente , Pascual-Morena Carlos
Published: February 2024

BACKGROUND

eHealth interventions have been postulated as a feasible, acceptable, and possibly effective tool to promote physical activity (PA) among children and adolescents; however, a comprehensive quantitative analysis of the effects of eHealth interventions promoting PA is lacking.

OBJECTIVE

This study aims to conduct a systematic review and meta-analysis on experimental studies reporting the effects of eHealth interventions aimed at promoting PA on PA parameters and sedentary behavior parameters in children and adolescents.

METHODS

The CENTRAL, MEDLINE, Embase, and Web of Science databases were searched from inception to February 2022 for randomized controlled trials that analyzed the effects of eHealth interventions aimed at promoting PA on PA and sedentary parameters in children and adolescents. The Hartung-Knapp-Sidik-Jonkman random effects method was used to determine the mean differences (MDs) with their respective 95% CIs. The risk of bias was assessed using the Risk of Bias 2 (RoB2; Cochrane) tool and its extension for cluster randomized controlled trials. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool.

RESULTS

A total of 20 trials reporting the effects of different eHealth interventions aimed at promoting PA were included. Results for each parameter were as follows: counts per minute (MD −16.11 counts, 95% CI −122.76 to 90.53; k=3; n=402; I2=69%; favoring control), steps per day (MD 593.46 steps, 95% CI −2102.27 to 3289.19; k=2; n=152; I2=0%; favoring intervention [FI]), moderate to vigorous PA (MD −1.99 min/d, 95% CI −8.95 to 4.96; k=14; n=2336; I2=86%; favoring control), light PA (MD 3.28 min/d, 95% CI −15.48 to 22.04; k=5; n=355; I2=67%; FI), screen time (MD −31.48 min/d, 95% CI −68.62 to 5.65; k=5; n=904; I2=0%; FI), and sedentary time (MD −33.12 min/d, 95% CI −57.27 to −8.97; k=8; n=819; I2=75%; FI). Our results should be interpreted cautiously because of important limitations such as the scarcity of evidence, overall risk of bias, and low to very low certainty of evidence.

CONCLUSIONS

We did not find conclusive evidence regarding the impact of PA-targeted eHealth interventions on PA parameters, but the very low certainty of evidence suggests that eHealth interventions may reduce sedentary time in children and adolescents. Our results may have important scientific implications as they highlight that the rapid development of eHealth interventions to promote PA lacks robust supporting evidence.

CLINICALTRIAL

PROSPERO CRD42020211020; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=211020
N-of-1 Trials of Antimicrobial Stewardship Interventions to Optimize Antibiotic Prescribing for Upper Respiratory Tract Infection in Emergency Departments: Protocol for a Quasi-Experimental Study (Preprint)
Authors: Attal Hersh , Huang Zhilian , Kuan Win Sen , Weng Yanyi , Tan Hann Yee , Seow Eillyne , Peng Li Lee , Lim Hoon Chin , Chow Angela
Published: February 2024

BACKGROUND

Antimicrobial stewardship programs attempting to optimize antibiotic therapy and clinical outcomes mainly focus on inpatient and outpatient settings. The lack of antimicrobial stewardship program studies in the emergency department (ED) represents a gap in tackling the problem of antimicrobial resistance as EDs treat a substantial number of upper respiratory tract infection cases throughout the year.

OBJECTIVE

We intend to implement two evidence-based interventions: (1) patient education and (2) providing physician feedback on their prescribing rates. We will incorporate evidence from a literature review and contextualizing the interventions based on findings from a local qualitative study.

METHODS

Our study uses a quasi-experimental design to evaluate the effects of interventions over time in the EDs of 4 public hospitals in Singapore. We will include an initial control period of 18 months. In the next 6 months, we will randomize 2 EDs to receive 1 intervention (ie, patient education) and the other 2 EDs to receive the alternative intervention (ie, physician feedback). All EDs will receive the second intervention in the subsequent 6 months on top of the ongoing intervention. Data will be collected for another 6 months to assess the persistence of the intervention effects. The information leaflets will be handed to patients at the EDs before they consult with the physician, while feedback to individual physicians by senior doctors is in the form of electronic text messages. The feedback will contain the physicians’ antibiotic prescribing rate compared with the departments’ overall antibiotic prescribing rate and a bite-size message on good antibiotic prescribing practices.

RESULTS

We will analyze the data using segmented regression with difference-in-difference estimation to account for concurrent cluster comparisons.

CONCLUSIONS

Our proposed study assesses the effectiveness of evidence-based, context-specific interventions to optimize antibiotic prescribing in EDs. These interventions are aligned with Singapore’s national effort to tackle antimicrobial resistance and can be scaled up if successful.

CLINICALTRIAL

ClinicalTrials.gov NCT05451863; https://clinicaltrials.gov/study/NCT05451836

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/50417
Authors’ Reply: Ambiguity in Statistical Analysis Methods and Nonconformity With Prespecified Commitment to Data Sharing in a Cluster Randomized Controlled Trial (Preprint)
Authors: Arguello Diego
Published: February 2024

UNSTRUCTURED

-

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/43018
indigenismos en el Florilegio medicinal de Juan de Esteyneffer (1712)
Authors: Ramírez Luengo José Luis
Published: February 2024

El presente trabajo procura analizar los indigenismos léxicos que aparecen en la primera parte del Florilegio medicinal del jesuita Juan de Esteyneffer, obra que se publica por primera vez en la Ciudad de México en los inicios del siglo XVIII (1712) y tiene múltiples reediciones durante todo el siglo. Los objetivos fundamentales que se buscan en este trabajo son cuatro: a) listar todos los indigenismos que Esteyneffer utiliza en el primer libro de su Florilegio; b) clasificar tales indigenismos desde diversos puntos de vista (origen etimológico, campos léxicos, etc.); c) analizar el grado de incorporación de algunos de los indigenismos en el español de la época; y d) indicar qué voces muestran su primera datación en esta obra. El propósito final es conseguir una visión más amplia y completa del léxico que durante el Siglo Ilustrado emplean los profesionales de la medicina en las diferentes regiones del Nuevo Mundo.
“Cuadernos de coca”: los trabajadores del narcotráfico en Mariposa blanca (1990) de Tito Gutiérrez
Authors: Fonseca Alberto
Published: February 2024

Las narconarrativas latinoamericanas han logrado representar el complejo mundo del narcotráfico desde diferentes modalidades y técnicas literarias. Mariposa blanca de Tito Gutiérrez utiliza una mezcla entre novela de aprendizaje y comentario social, para aproximarnos a la realidad cambiante del tráfico de drogas en Bolivia. Con la historia de Lázaro, un estudiante de la ciudad de Cochabamaba que viaja a la capital de las drogas en el Chapare boliviano, Gutiérrez trabaja con las ansiedades de una sociedad que ve trastocados sus valores culturales y su trabajo. El texto de Gutiérrez ilustra magistralmente la tensión que existe entre el uso tradicional de la coca frente a la producción de cocaína, y la crisis cultural y económica que trae el tráfico de drogas a la región andina.
Motivos caballerescos en El vasauro de Pedro de Oña: el requerimiento amoroso y la penitencia de amor
Authors: Campos García Rojas Axayácatl
Published: February 2024

El artículo analiza dos motivos caballerescos (el requerimiento amoroso y la penitencia de amor) en El vasauro, poema de Pedro de Oña. En este estudio se busca identificar y analizar los motivos que caracterizan la literatura caballeresca en una obra de 1635, cuando el género de los libros de caballerías hispánicos comenzaba su declive editorial. Sin embargo, a través de este análisis se pone de manifiesto la pervivencia de los recursos propios de las obras caballerescas más allá del siglo xv y en la literatura virreinal hispánica. Se destaca también los elementos procedentes de la literatura de pastores.
descomposición del lenguaje y la extinción de la literatura en la narrativa breve de José María Merino
Authors: Cabrera Espinosa Claudia
Published: February 2024

Los cuentos fantásticos de José María Merino abordan temas como la identidad, la descomposición social y la falta de sentido de la existencia. Para exponerlos en su narrativa, recurre a hechos fantásticos como las metamorfosis, el desdoblamiento de la personalidad y la desintegración corpórea, entre otros. En este trabajo abordamos tres relatos (“Las palabras del mundo”, “Los libros vacíos” y “El viaje inexplicable”) en donde las preocupaciones principales del autor son la descomposición del lenguaje y el fin de la ficción y la lectura.
¿Lo que no se mide no existe? El problema con los indicadores en materia de derechos humanos para los poderes judiciales
Authors: Suárez Ávila Alberto Abad
Published: February 2024

El uso de indicadores para medir las problemáticas sociales se ha extendido desde hace más de tres décadas como parte de la gobernanza global, fenómeno del cual las organizaciones públicas forman parte activa, incluidos los poderes judiciales. Los indicadores se utilizan en la judicatura de manera cotidiana: las administraciones centrales los emplean como insumo para elaborar su política judicial y rendir cuentas, mientras que los operadores de justicia los usan como una herramienta indispensable para la gestión diaria de sus cargas de trabajo. El gran atractivo de los indicadores es que pueden ayudar a los poderes judiciales a modernizarse a través de metodologías científicas. A pesar del atractivo que tienen los indicadores en derechos humanos, existen una serie de problemáticas relacionadas con su implementación que deben ser observadas por los tribunales. Desde el análisis de la literatura especializada y con referencia al caso mexicano, este artículo aborda algunas de las principales, las cuales se concentran en cinco aspectos: 1) indicadores ¿para qué?; 2) la gobernanza de los indicadores; 3) las epistemologías de derechos humanos que se utilizan en su construcción; 4) los efectos sobre la cultura organizacional, y 5) los límites a la búsqueda de legitimidad que persiguen con su adopción.
La ciudad novohispana: del tardomedievo a la modernidad
Authors: Tormo Camallonga Carlos
Published: February 2024

Este artículo tiene por objetivo abordar a la ciudad como una institución jurídica y político-institucional. Para ello, partirá de estudiar los modelos de ciudad peninsulares —en particular, el de la corona de Aragón— y su posible repercusión en las Indias. Destacará así el papel de la ciudad en sus dimensiones espacial, jurídica, social y política-institucional, mismas que permiten entender la transición y cambios de las ciudades bajomedievales peninsulares y de las ciudades modernas en las Indias.
Derechos y actos jurídicos inscribibles en el sistema registral paraguayo
Authors: Salinas González Claudio Arnaldo Manuel , Flecha Lima René
Published: February 2024

La investigación versa sobre el derecho registral, en cuanto a su evolución histórica, el sistema registral utilizado en el Paraguay, la organización y funcionamiento del Registro Público, y, en específico, sobre aquellos actos y derechos cuya viabilidad de inscripción se encuentra establecida por ley, específicamente en el Código Civil Paraguayo y en el Manual Técnico Registral. Se identifican cuáles son aquellos actos y derechos que por su naturaleza y validez deben encontrarse inscritos en el registro público. Se enuncian los diversos principios registrales existentes, resaltando su importancia y la riqueza de contenido que aportan como ideas rectoras. Se profundiza acerca de la publicidad registral, delimitando sus notas distintivas, y diferenciándola de la publicidad noticia. Finalmente, se hace un análisis en cuanto a los actos y derechos inscribibles en el sistema registral paraguayo, enunciando las normativas legales que rigen la materia, también se diferencian los instrumentos públicos de los privados; se individualizan los diversos tipos de actos jurídicos teniendo en cuenta las formalidades de cada uno respecto a si deben ser inscritos para su validez, o, si dicho requisito puede ser dispensable para ciertos actos jurídicos. Por otro lado, se culmina con la investigación acerca del sistema Numerus Clausulus, el cual versará específicamente acerca de los derechos reales.
Keyboard and Mouse Free Music Controller
Authors: Gupta Rahul Kumar , Saxena Varun
Published: February 2024

Abstract: Human-machine interface (HMI) is a crucial area of research as gestures have the potential to efficiently control and interact with computers. Many applications for hand detection have been created as a result of the pervasive use of built-in cameras in computers, smartphones, and tablets. For the majority of users, however, many of these are not useful. A straightforward concept for a keyboard- and mouse-free music controller is presented in this research. Using MATLAB code that integrates skin detection, area labelling, erosion, dilation, and motion differentiation, a music player controller is developed using the real-time frame tracking feature of a camera. Three hand detection algorithms are created and assessed for maximum performance and accuracy. Real-time hand detection for operating the music player is provided by the algorithm, which is created with efficiency and speed in mind.
Promoting student’s habits of mind and cognitive learning outcomes in science education
Authors: Ariyati Eka , Susilo Herawati , Suwono Hadi , Rohman Fatchur
Published: February 2024

: Learning must be able to develop knowledge, skills, and mindsets so that the graduates produced have attitudes, abilities and knowledge that are integrated and skilled in life. One way to achieve learning can be done through habits of mind  because the success of learning is strongly influenced by   habits of mind. The purpose of this study is to as certain how habits of mind and cognitive learning outcomes in biology are affected by learning process oriented guided inquiry learning  with blended learning support. A pretest-postest design wih a non-equivalent control group was employed in this study. The trial ran from February to June 2022. Utilizing the habits of mind questionnaire, pupils’ thought patterns were assessed. Essay tests are also used to evaluate the results of cognitive learning. In this study, google form, LMS, and google meet were used for data collection. Statistical Product and Service Solutions software version 23 is used for data analysis and the results of covariance analysis (ANCOVA) showed a p value < 0,005, meaning that POGIL-supported blended learning can empower habits of mind and cognitive learning outcomes in biology learning. There is a substantial difference between the outcomes of the least significant difference and increasing habits of mind and cognitive learning outcomes. As a result, POGIL with moodle support can be used to enhance students’ habits of mind and cognitive learning results in biology classes.
Factores asociados al pronóstico de morbimortalidad en pacientes pediátricos con absceso cerebral
Authors: Pérez-Cárdenas Sofy Helena , Márquez-Herrera Kelly Christina , Echeverría-Palacio Carlos Mario , Cárdenas-Hernández Vicky Carolina , Parrado-Sánchez Zayra Daniela , Bustos-Acosta Juan Carlos
Published: February 2024

Introducción: El absceso cerebral, aunque poco frecuente en la población pediátrica, es una entidad con alta carga de morbimortalidad. El reconocimiento de las manifestaciones clínicas iniciales y la epidemiología local permite realizar un diagnóstico temprano y un tratamiento oportuno, lo que lleva a mejorar la sobrevida y evitar secuelas. Objetivo: Determinar las características clínicas, paraclínicas y los factores asociados a morbimortalidad de pacientes pediátricos con diagnóstico de absceso cerebral atendidos en un hospital pediátrico de alta complejidad en un periodo de 5 años. Métodos: Estudio observacional, con componente descriptivo y analítico. Se recolectaron los datos sociodemográficos, factores de riesgo y variables derivadas del curso de la enfermedad como la presentación clínica, resultados de ayudas diagnósticas, hallazgos microbiológicos, tratamiento recibido y complicaciones de los pacientes incluidos. Al final se exploraron las posibles asociaciones con respecto a las variables de interés planteadas. Resultados: Se incluyeron en total 32 pacientes con absceso cerebral, 68,8 % de sexo masculino, con un promedio de edad de 120 meses, sin encontrar factor predisponente o comorbilidad en 81,3 %. La localización más frecuente del absceso fue frontal (50 %) y el foco infeccioso más común fue la sinusitis (50 %). Los síntomas más frecuentes fueron la cefalea (65,7 %) y las crisis epilépticas (62,5 %). El esquema antibiótico más utilizado fue ceftriaxona + vancomicina en el 43,3 % de los pacientes, con una mediana de tiempo de 21 días, la mediana de tiempo de hospitalización fue de 32 días. El 37,5 % de los pacientes requirió ingreso a Unidad de Cuidado Intensivo (UCI) con una mediana de estancia de 3 días y el 75 % requirió drenaje quirúrgico. Se logró la recuperación del agente etiológico en 28 % de los casos, siendo S. aureus (n=3) y S. pneumoniae (n=2) los microorganismos más frecuentes. El 68,8 % de los pacientes no tuvo complicaciones y el 50 % no tuvo secuelas neurológicas. La secuela más frecuente fue la hemiparesia (15,6 %), los signos de focalización se resolvieron en una mediana de 40 días. Conclusión: En la población estudiada se encontró una asociación significativa entre la necesidad de UCI y la presencia de cefalea (p 0,018; OR 11, IC95% 1,1-101,9) y signos de focalización neurológica al ingreso (p 0,033; OR 5,5, IC95%1,1, 27,5). Los pacientes que tuvieron crisis epilépticas tempranas se asociaron a una mayor probabilidad de desarrollar epilepsia con respecto a quienes tuvieron crisis tardías y los que no tuvieron crisis (p 0,035; OR 27, IC95% 1,6, 442,8).
Guía de práctica clínica para el diagnóstico y tratamiento de la criptococosis en personas adultas que viven con el VIH
Authors: Cortés Jorge Alberto , Valderrama-Rios Martha Carolina , Lizarazo Jairo , Millán-Oñate José , Diaz-Brochero Cándida , Gómez Quintero Carlos Hernando , Nocua-Báez Laura Cristina , Martínez Buitrago Ernesto , López María José , Remolina-Granados Sergio Andrés , Castañeda Elizabeth , Escandón Patricia , Gómez Juan Carlos , Hernández-Rojas Enrique Steff , Varón-Vega Fabio , Álvarez-Moreno Carlos Arturo
Published: February 2024

La criptococosis es la infección fúngica ocasionada por el complejo de especies Cryptococcus neoformans y Cryptococcus gattii, desarrollada con mayor frecuencia en personas con compromiso del sistema inmune. En las personas que viven con el virus de la inmunodeficiencia humana (VIH), la criptococosis es una infección oportunista de gran importancia, con consecuencias devastadoras para los pacientes, la sociedad y el sistema de salud, debido al incremento en morbilidad, mortalidad y costos que genera. La presente guía contiene recomendaciones para el diagnóstico y tratamiento de la criptococosis en personas adultas que viven con el VIH, basadas en la evidencia, realizadas mediante el proceso de adaptación de guías de práctica clínica internacionales para el contexto colombiano.
Effect of Thermal Activation on the Mineralogical Structure of Magnesium Slag
Authors: Korkmaz Abdul Vahap
Published: February 2024

Magnesium slag's production process is similar to the Portland cement production process. The raw material used is carbonate-containing dolomite, and is calcined in a rotary kiln at 850-900 oC. Afterwards, ferrosilicon and fluorite raw materials are added to the calcined material, they are ground together and turned into pellets, and then they are reduced at a temperature close to the firing temperature of Portland cement clinker (1250-1350 oC) to obtain crown magnesium and magnesium slag. The reduction time of pellet material in reduction furnaces is 12 hours. During this period, almost all of the magnesium minerals in the mixture material are reduced and taken as crown magnesium metal. The remaining material, described as magnesium production slag (reduction furnace waste), consists of Alite (C3S), Belite (C2S), Celite (C3A) and C4AF minerals contained in Portland cement clinker. Some of the minerals contained in Portland cement clinker in the rotary kiln are formed at temperatures below 1400 °C, which is the clinker firing temperature. The only difference other than the firing temperature is that after the Portland cement clinker is fired in the rotary kiln, the clinker is cooled rapidly, increasing the alite (C3S) crystals formed in its structure and preventing the alite minerals from turning back into belite (C2S) minerals. This study produced magnesium slags at different temperatures (1200-1350 oC) by thermal activation method in an industrial environment. The Bogue and XRD methods calculated the mineral phase amounts of the products produced.
Inovando a partir de uma análise de custo-benefício com base em indicadores de desempenho do Palivizumabe 2019/2020 em uma Unidade Neonatal no município de Niterói, Rio de Janeiro
Authors: VALMONT HELEN CRISTINE
Published: February 2024

Abstract
Innovation process in the health area has promoted changes in management and with a consequential improvement of the cost benefit of patient treatment (Christensen,2009). The use of indicators that come to measure management performance through balanced metrics - balanced scorecard (Kaplan, 1996) has even more contributed to this management with the use of indicators and correlation between them. This research aims to perform a comparative analysis with newborns in international between february and july 2019 and 2020, period of the seasonality of application of palivizumabe, in neonatal unit, using the indicator model. The data collection was performed through the protocol of application of this medication. The objective is to perform comparative analysis in order to identify the relevance of usingthe method, reducing material costs and resources, and a significant and effective improvement in the actions developed as, when used and permitting, in the use of the permanent resources of management, taking the feedbacks of the miscellaneous professionals involved, as well as the client, with assertive use, avoiding increased increase in stays and return to the hospital. We can observe that there was a considerable cost reduction and a significant 65% saving on the final value of the product for the company.
Keywords: Balanced Scorecard; Cost-benefit; Neonatal; Palivizumabe.
Industry 4.0: The role of small and medium-sized entreprises in Germany
Authors: Amorim Vanessa , Bernardes Óscar , Santos Bárbara , Rua Orlando
Published: February 2024

Purposes: In the present study, the concepts inherent to Industry 4.0 and Mittelstand will be initially defined in a clear way, for a better understanding of the context under analysis. Afterwards, the current situation of Industry 4.0 in the German SME sector will be evaluated, presenting as results the respective inherent challenges and opportunities. In this follow-up, the research will conclude whether the concept of Industry 4.0 can represent a key success factor for the SME sector in Germany.

Methodology: The data analysis in the present research are based on a bibliographic review and an analysis of statistical data, seeking to represent a combination of quantitative and qualitative approaches.

Results: The challenges analyzed and discussed may be a possible justification for a slow reversal of traditional production processes for Industry 4.0. However, the numerous opportunities and their high implementation potential are preponderant for the adoption of the 4.0 industry in the production processes of the future.

Conclusions: This research shows that currently, there is still a high percentage of companies in the German SME sector that have not implemented Industry 4.0. However, the opportunities presented throughout the study, overcome the possible challenges posed in this context, as Industry 4.0 can considerably increase the profitability and efficiency of production as well as the overall competitiveness of the organization.

Keywords: digitization; industry 4.0; mittelstand; SME.
ANALYSIS OF THE FACTORS THAT FACILITATE THE CREATION OF KNOWLEDGE AND INNOVATION IN PUBLIC ORGANIZATIONS
Authors: Matela Lobosco Letícia , Picinini Méxas Mirian , Meirelles Drumond Geisa , Dias Ana Claudia , Correia da Silveira Batista Haydée Maria
Published: February 2024

The age of knowledge has brought new values, new ways of relating, doing business, learning. Public organizations need to adapt to this new reality and review their processes. Thus, this article aims to analyze the factors that influence the creation of organizational knowledge and innovation in the public sector. For that, it was adopted the methodology of a case study in a federal teaching institution. As a research tool, it was used a semi-structured interview script. The results of this study showed that the factors of commitment and teamwork are evaluated positively. In addition, there are flaws in factors such as communication and interorganizational network. Because it is a case study, this research presents as a limitation the impossibility of the results generalization, nevertheless it can serve as an input for other institutions whose focus is the progress of knowledge, creation and innovation.  This article aims to contribute to scientific knowledge in the field of innovation in public administration, highlighting the importance of continuous improvement.
Kedudukan Peradilan Pajak dalam Sistem Peradilan di Indonesia
Authors: Mushawirya Rustian
Published: February 2024

This paper was prepared against the background of the unclear position of the Tax Court in the judicial system in Indonesia. This research uses normative juridical methods supported by data collection techniques using literature studies intended to obtain secondary data. In conducting this research, the type of research used by the author is normative juridical, or also often referred to as normative legal research. The choice of this type of research is intended to obtain theoretical matters, principles, conceptions, legal doctrines, and legal methods related to the position of tax justice in the judicial system in Indonesia. The issues studied in this study are the position of the Tax Court in the judicial system in Indonesia, and whether the tax dispute resolution mechanism according to Law No. 14 of 2002 is in line with the principle of judicial power in Indonesia. This research uses.
Green synthesis of size-controlled silver nan particles and their anti-cancer potentiality
Authors: Kabir M. F. , Rahman M. Z. , Ferdousy J. , Atique Ullah A. K. M , Razzakul M. Foysal, I. M. , Rahman M. M.
Published: February 2024

Silver nanoparticles (Ag-NPs) are now well recognized as one of the most prevalent kinds of materials that are put to use in a wide variety of biomedical applications, most notably as an anti-cancer agent. In the current investigation, Ag-NPs were effectively produced by reducing silver ions by employing the leaf extract of Artocarpus heterophyllus as a source of reducing and capping agents. By altering the quantity of the silver nitrate solution, we successfully synthesized three distinct kinds of Ag-nanoparticles that were mediated by Artocarpus heterophyllus leaf extract. The X-ray diffraction (XRD) analysis first confirmed the formation of metallic silver, where peaks were found at fixed angles. XRD method was also used to validate the crystal geometry of the Ag-NPs, revealing that the Ag-NPs had a face-cantered cubic structure. The calculated average crystallite sizes of Sample-1 Ag-NPs, Sample-2 Ag-NPs, and Sample-3 Ag-NPs were 20.34 nm, 16.99 nm, and 18.88 nm, respectively. Ag-NPs were also confirmed from EDX analysis and firm Ag peaks, including several organic compound peaks. The nanoparticle’s range was between 120 nm and 220 nm, and the average particle size was near 170 nm, as found in the SEM image, and accumulation was observed in the SEM image. Using Fourier Transform Infrared (FT-IR) spectroscopy, we determined the functional groups of organic compounds that might be responsible for reducing agents and the presence of capping agents on the surface of Ag-NPs. The cell viability test was used to assess the cytotoxicity using the HeLa cell, a human carcinoma cell. The results revealed that the produced Ag-NPs demonstrated toxicity against carcinoma cells.
Implicações da regulação do acesso à educação superior no Espírito Santo
Authors: Teixeira Maia Zilka Sulamita , Santos Wagner dos
Published: February 2024

Este artigo visa discutir os efeitos e desdobramentos concretos das políticas educacionais nacionais de acesso à educação superior implementadas nas redes públicas do Espírito Santo entre 1997 e 2017. Orientado pelo marxismo histórico-dialético, produziu-se uma análise documental a partir de indicadores educacionais e demográficos. Evidenciou-se que a materialização das regulamentações nacionais na rede pública que oferta a educação superior no estado do Espírito Santo, entre 1997 e 2017, expressa as diferentes formas de regulação estatal, demonstrando inicialmente estreitamento e, no período mais recente, especialmente a partir de 2012, o alargamento do acesso de camadas mais pobres da população (especialmente pretos, pardos e indígenas) ao nível mais elevado de ensino.
Investigation of dye-sensitized solar cell performance based on vertically aligned TiO2 nanowire photoanode
Authors: Shougaijam Biraj , Singh Salam
Published: February 2024

In this work, we present our results related to the development of
Dye-Sensitized Solar Cells (DSSCs) based on vertically aligned TiO2-nanowire
(NW) and Ag nanoparticle (NP) assisted vertically aligned TiO2-NW (TAT)
photoanode fabricated by the glancing angle deposition (GLAD) technique on
fluorine doped thin oxide (FTO) substrates. The scanning electron microscopy
(SEM) analysis reveals that the Ag-NP assisted vertically aligned TiO2-NW
photoanode was successfully deposited on FTO substrates. The average length
and diameter of the NW have been measured to be ~ 350 nm and ~ 90 - 100 nm,
respectively. Moreover, transmission electron microscopy (TEM) and X-ray
diffraction (XRD) manifest the presence of small crystals of TiO2 and Ag.
Further, the absorption spectrum analysis reveals that the incorporation of
Ag-NP in TiO2-NW increases absorption in the visible region, but decreases
the efficiency of the cell after the incorporation of the nanoparticle. The
calculated bandgap of the annealed Ag-NP (30 nm) assisted TiO2-NW (TAT@30nm)
sample from the photoluminescence (PL) graph is ~ 3.12 eV. Finally, it is
observed that the TiO2-NW based DSSC device shows better performance in
terms of photo conversion efficiency (PCE) compared to the TAT@30nm
photoanode based device, with an efficiency of ~0.61 % from the former and ~
0.24 % from the latter. This reduction in the efficiency of TAT@30nm based
devices is due to the larger size of Ag-NP, in which the nanoaprticle acts
as an electron sink and acts as a blocking layer.
The Fredkin gate in reversible and quantum environments
Authors: Moraga Claudio , Hadjam Fatima
Published: February 2024

Reversible Computing circuits are characterized by low power consumption and
their proximity to circuits for quantum computing. The Fredkin gate was one
of the earliest proposed controlled reversible circuits, which however, was
soon superseded by the Toffoli gate, the NOT, and CNOT gates, which
constituting a flexible functionally complete set could also realize the
Fredkin gate as a building block. In quantum computing circuits, the Fredkin
gate (under the name controlled SWAP) plays an important role regarding the
superposition of states. The present paper studies extensions of the Fredkin
gate in terms of mixed polarity in the reversible domain and an application
in quantum computing.
Life quality of patients with rheumatoid arthritis treated with biotherapy
Authors: Obradovic-Gajic Jelena , Boskovic Ksenija , Zvekic-Svorcan Jelena , Igic Natasa
Published: February 2024

Introduction. Rheumatoid arthritis is a chronic disease that causes joint
damage and loss of function, thus impairing quality of life. Administration
of biological drugs can change the course of the disease and improve life
quality and functional capacity of patients. The objective of the study is
to examine the quality of life in patients with rheumatoid arthritis treated
with biological therapy. Material and Methods. The prospective
cross-sectional study followed 56 patients of both sexes treated with
biological drugs at the Special Hospital for Rheumatic Diseases, Novi Sad.
The data were collected using a standardized questionnaire for monitoring
the quality of life (Health Assessment Questionnaire-disability index) and
a general questionnaire, containing socio-demographic data, disease and
therapy data. Computer program Statistical Package for the Social Sciences
version 24 was used for data processing. Results. The results of the
assessment of the life quality of patients with rheumatoid arthritis
undergoing biological therapy showed that the values of the Health
Assessment Questionnaire-disability index range from Min=0.00 to Max=2.25,
with the mean M=0.76. Observed by category, 39.3% of participants are in
remission, while the rest (60.7%) have low disease activity. The Health
Assessment Questionnaire-disability index has a statistically significant
correlation with the place of residence (p<0.05), as well as with the
duration of morning stiffness (p<0.01). The Health Assessment
Questionnaire-disability index has no statistically significant correlation
with other general data, disease and therapy data. Conclusion. Applica?tion
of biotherapy on patients with rheumatoid arthritis leads to low disease
activity and remission, which results in good quality of life.
Institute for rural studies of the Serbian Academy of Sciences: 1947-1954
Authors: Isic Momcilo
Published: February 2024

The SAS Institute for the Rural Studies, within the Department of Social
Sciences, was founded on June 10, 1947, with the appointment of Sreten
Vukosavljevic, a professor at the Faculty of Law in Belgrade, as its
manager. The basic task of the Institute was to study the development of
social life in the countryside, the existence and development of land
ownership, the organization of the village as a settlement, the organization
of the family settlement, the evolution of the organization of agricultural
and other works; consanguinity, birth rate and sexual morality; forms of
behavior; religious life and the religious world, helping each other,
leisure and entertainment, health and consciousness, etc. Due to the lack of
sufficient staff, especially professional staff, and then the opposition of
the Institute?s most influential associates to the demands of the manager
Sreten Vukosavljevic, the Institute was slow to realize the set goals and
tasks, which ultimately resulted in the resignation of Sreten Vukosavljevic,
and then the closure of the Institute on March 1, 1954.
Orthodox Christianity in Serbia from 1990s until nowadays: Beliefs and practices of active believers context, concept and preliminary research results
Authors: Pavicevic Aleksandra
Published: February 2024

In this text, the religious revival is discussed as a continuous process that
evolved in Serbia from 1990s until nowadays. The historical and cultural
contexts of this process are described, but also underlined less explored
field of liturgical renewal which reflected inner transformations of life of
Serbian Orthodox Church. These parallel flows - one that was focused on
collective identity strategies and the other related to personal
spirituality, shaped religious revival in Serbia. Aim of project to which
articles in this issue are dedicated is to research believes and religious
practices of the so-called active believers of SOC. Thus, this paper also
brings overview of preliminary research results and announces complexity of
the phenomenon that will be analyzed in further readings of rich
ethnographic material collected during field work in different regions of
Serbia.
Influence of church orthodoxy on intangible cultural heritage: Reduction, transformation and disappearance of local folk customs
Authors: Andjelkovic Biljana
Published: February 2024

This article presents the results of research into the religiosity of
churchgoers of the Serbian Orthodox Church with a special focus on the
connection between active participation in liturgical life and attitudes
towards elements of traditional culture and customs of the individual?s life
cycle. The aim of the article was to show, through the analysis of
narratives and attitudes of church believers about folk beliefs and customs,
the influence that the acceptance of Orthodox teaching has on the reduction,
transformation and disappearance of certain customs. Ethnographic research
was conducted within the project ?Ecclesiastical and Religious Practices of
Christian Orthodox Believers in Serbia: Anthropological Research?
(2021-2023).
Does Status Equal Substance? The Effects of Specialist Social Status on Auditor Assessments of Complex Estimates
Authors: Gold Anna , Kadous Kathryn , Leiby Justin
Published: February 2024

Auditing standards require that auditors’ reliance on a specialist is commensurate with the specialist’s competence. In assessing competence, auditors encounter cues diagnostic of the specialist’s social status but less so of competence. In an experiment, we manipulate specialist status and find that auditors mistake status for competence unless they are prompted to separate the constructs. This raises the possibility that auditors could over-rely on high-status specialists. However, auditors also assess high-status specialists as more influential, and when the specialist disagrees with the client, they rely more on high-status specialists because of this perceived influence. Thus, high-status specialists can increase auditors’ willingness to challenge the client by providing a strong ally. Additional analyses suggest that auditors are aware that they rely on the specialist’s influence rather than competence, indicating that auditors do not use the process that auditing standards envision to evaluate and rely on specialists.

Data Availability: Data are available upon request.

JEL Classifications: M42.