bluuebunny/crossref_metadata_2025 huggingface dataset:
Attitude and Use of Pentavent Vaccine among Pregnant Women Attending Antenatal Care in Plateau State Specialist Hospital, Jos, Nigeria
Authors: Okafor Kingsley Chinedu , Isah Haroun O. , Bimba J. S. , Thilza S. , Parah Zainab G.
Published: July 2019

Background: The World Health Organization (WHO) and the Global Alliance for Vaccines and Immunizations (GAVI) recommended the use of Pentavelent vaccines in Nigeria and other developing countries to replace the DPT (Diphtheria, pertusis and tetanus) vaccine. This was done to increase the uptake of the hepatitis B (HB) and Haemophilus influenza type b (Hib) vaccines in these countries by capitalising on the uptake of DPT vaccine. Objective: This study aims to assess the attitude and use of pentavalent vaccine in pregnant women attending antenatal care in a Tertiary Hospital in Jos, Plateau State. Methods: The study was carried out among pregnant women receiving antenatal care in Plateau Specialist hospital, Jos using a descriptive cross sectional study design. The study was done over a period of four (4) months (August 2018 to December 2018). Simple Random Sampling was used to select 397 women who participated in the study. Results: Respondents were predominantly Christians 283 (71.3%) while Muslims represent about 114 (28.7%) of respondents. About 373 (94%) respondents were married, While 24 (6.0%) percent of the respondents were single parents. Also 213 (53.7%) were business women, Only 48 (12.1%) were civil servants while 85 (21.4%) of the respondents had no form of employment. Majority 257(97.0%) of them had a positive attitude towards the vaccine while only a few 8(3.0%) had a negative attitude.Eighty eight (32.2%) felt pentavalent vaccines were not important. A similar proportion 88 (3.2%) also stated that they would not give their child the vaccine. Most women 252 (95.1%) agreed that mothers should be encouraged to attend immunization regularly. Side effect experienced by children were fever 69 (87.3%), swelling at injection site 21 (26.6%), rash 6 (7.6%). Conclusion and recommendations: All most all pregnant women had a positive attitude towards the vaccine while only a few had a negative attitude. Nine in ten women had children who had received pentavalent vaccine.Health workers should improve efforts at health education on immunization especially on adverse effects following immunization (AEFI), reasons for missed opportunities, coverage of hard to reach areas or distant areas via special immunization or home visiting to administer vaccine.
Transfixant Injuries of the Mediastinum: Always A Challenge
Authors: Barros Wysterlânyo Kayo Pereira , Sizenando Isadora Priscila de Oliveira , Medeiros Tâmara Azevedo de , Medeiros Thomas Di Nardi , Silva Wagner Gomes Da Nóbrega , Rêgo Amália Cinthia Meneses , Filho Irami Araujo
Published: July 2019

Transfixant injuries of the mediastinum are those in which the aggressor object travels through the midline of the thorax, where the mediastinum is located, being associated with high morbidity and mortality. This review of the literature addressed several aspects of the theme, including diagnosis and treatment. A search was carried out in Pubmed, Scopus and Scielo databases, using indexed descriptors and selection of articles by peers. Mortality rates from 20% to 87% among the victims of this injury modality were observed, varying due to the proportion of unstable patients. In patients undergoing thoracotomy resuscitation, mortality rates between 85-100%. The treatment consisted of maintaining the patient's hemodynamic status, so that patients with imminent death in the emergency service should undergo resuscitation thoracotomy, unstable patients should undergo emergency thoracotomy After a brief clinical/diagnostic evaluation, while stable patients benefit from further investigation and in up to 60% of the cases, do not require a surgical approach. It was concluded, therefore, that such lesions are associated with high morbidity and mortality, and their approach differs according to the patient's hemodynamic profile in the emergency room. Emergency services should be prepared to meet this new patient profile, which arrives at prompt care with severe injuries and increasingly critical clinical conditions.
Pengembangan Modul Berbasis Education for Sustainable Development pada Konsep Ekologi untuk Siswa Kelas X SMA
Authors: Rahman Aditya , Heryanti Lucya Mega , Ekanara Bambang
Published: July 2019

This research aimed to develop a product and to find out its eligibility and students�s response of module based education for sustainable development (EfSD) on ecology concept for X grade students. Research and development (R&D) method with Dick & Carey model was used in this research. It consisted of 5 stages, that were Analysis, Planning, Development, Formative Evaluation, and Revision. Instrument validation was assessed by experts (concept, media and teachers). According to the result of expert assesment, the module earned score 94%. The score was included into very decent category. The score of students�s response was 84,4%. The score was included into very worth category. It can be concluded module based EfSD on ecology concept for X grade students was very decent for learning material.
Kepraktisan Bahan Ajar Statistika Pendidikan Fisika Bermuatan Model Cooperative Problem Solving
Authors: Afrizon Renol , Dewi Wahyuni Satria
Published: July 2019

The statistics of physics education are compulsory course with a lot of material descriptions so the lectures must be assisted by the use of teaching materials. The lectures of statistics of physics education that took place in the July-December 2017 semester illustrates that: 1) teaching materials are less attractive to students, 2) the assignments given are quite clear and sufficient in accordance with the level of thinking of students, 3) materials delivered by the lecturer is in accordance with the targets in the syllabus with some material is still abstract, 4) the lecture have been pursued in accordance with the syllabus but the methods used have not varied and 5) students learn material of statistic of physics education only from the lecturer explanation so that only a few students can answer statistical problems quickly and correctly. This indicates that it is need provided teaching materials with a cooperative problem solving model. The author has tried to design teaching materials of statistic of physics education with cooperative problem solving models with very valid criteria according to the assessment of six experts with educational qualifications of statistics and physics education. However, this teaching material has not been tested at normal conditions in the lectures so that the level of practicality has not been revealed. The aim of this study was to determine the practicality level of educational statistical teaching materials containing cooperative problem solving models according to users, namely lecturers and students who listed in the course. Type of research is research and devel-opment with the ADDIE model. The ADDIE model stands for Analyze, Design, Develop, Implement and Evaluation. This research is part of the Implementation stage where development products are implemented in real terms so that the level of practicality can be measured with indicators of ease of use, attractiveness and efficiency. Data collection used student response questionnaires and lecturer response questionnaires with a Likert scale. Data analysis used descriptive statistic analysis techniques. The results showed that teaching materials of physics education statistics had very practical criteria (lecturers opinion) and practical (students opinion). The conclusion of this study is the teaching materials of statistic of physics education with cooperative problem solving model has been practically used in lectures
ANALISIS TINGKAT KEPUASAN SISTEM INFORMASI PENCATATAN DAN PENAGIHAN BIAYA REKENING AIR PELANGGAN PDAM MENGGUNAKAN METODE END USER COMPUTING SATISFACTION (EUCS)
Authors: Anwar Muhammad , Azisan Muhammad
Published: July 2019

This study aims to examine the effect of the End User Computing Satisfaction variable on user satisfaction of the information system application. Recording and collection of customer water costs for PDAM Kota padang. This analysis uses independent variables, namely content, accuracy, format, easy of use, and timeliness. the application user satisfaction. Samples of this research are PDAM employees: billing, service, cashier, finance, IT and director directors and recording records. Samples were conducted using the proportionate stratified random method. Data collection was done by questionnaires distributed directly to respondents 78 questionnaires. Instead it was distributed to PDAM employees by measuring using a Likert scale after it was tested for validity and reliability. Data analyzed would use a questionnaire questionnaire. Samples were taken at PDAM Kota Padang. Statistical methods used Multiple Linear Regression Analysis. The results of the analysis of a data show: All instruments on EUCS simultaneously have an influence in recording and collection of water costs for PDAM customers. The use of EUCS has a significant effect on the recording and collection of customer water costs at PDAM Padang City.
IMPLEMENTASI JARINGAN SYARAF TIRUAN DALAM MEMPREDIKSI FREKUENSI RESONANSI ANTENA MIKROSTRIP
Authors: Budayawan Khairi , Yuhandri Yuhandri , Nurcahyo Gunadi Widi
Published: July 2019

The resonant frequency of an antenna is determined by the dimensional parameters and permittivity of the antenna substrate. Generally, to get the resonant frequency, a complex mathematical formula is needed to solve. For this reason, an intelligent method is offered to determine the resonant frequency more easily. In this study, an artificial neural network method with Backpropagation algorithm is used to overcome the problem. The data used were consisting of 80 training data and 15 testing data. The results have shown that the artificial neural network learning method with the backpropagation algorithm was successfully utilized to calculate the resonant frequency of microstrip antennas, where the precision of the resonant frequency obtained of 93.33% at an error of = 1%, and 100% at an error of = 2%.
PERANCANGAN SISTEM DETEKSI OBJEK PADA ROBOT KRSBI BERBASIS MINI PC RASPBERRY PI 3
Authors: Sugianda Ilfan , Thamrin Thamrin
Published: July 2019

KRSBI Wheeled is One of the competitions on the Indonesian Robot Contest,. It is a football match that plays 3 robot full autonomous versus other teams. The robot uses a drive in the form of wheels that are controlled in such a way, to be able to do the work the robot uses a camera sensor mounted on the front of the robot, while for movement in the paper author uses 3 omni wheel so the robot can move in all directions to make it easier towards the ball object. For the purposes of image processing and input and output processing the author uses a Single Board Computer Raspberry PI 3 are programmed using the Python programming language with OpenCV image processing library, to optimize the work of Single Board Computer(SBC) Raspberry PI 3 Mini PC assisted by the Microcontroller Arduino Mega 2560. Both devices are connected serially via the USB port. Raspberry PI will process the image data obtained webcam camera input. Next, If the ball object can be detected the object's position coordinates will be encoded in character and sent to the Microcontroller Arduino Mega 2560. Furthermore, Arduino mega 2560 will process data to drive the motors so that can move towards the position of the ball object. Based on the data from the maximum distance test results that can be read by the camera sensor to be able to detect a ball object is �5 meters with a maximum viewing angle of 120 �.
PERBANDINGAN METODE EDAS DAN ARAS PADA PEMILIHAN RUMAH DI KOTA PONTIANAK
Authors: Midyanti Dwi Marisa , Hidayati Rahmi , Bahri Syamsul
Published: July 2019

Dalam masalah pengambilan keputusan, teknik dan model dari Multi Criteria Decision Making (MCDM) sangat sering digunakan, dan berkembang sangat pesat. Pada penelitian ini menggunakan dua metode MCDM yaitu EDAS dan ARAS pada pemilihan rumah di Kota Pontianak. Metode EDAS didasarkan pada skor penilian (AS) tertinggi untuk mendapatkan pilihan terbaik dari semua alternatif, sedangkan metode ARAS menggunakan nilai utilitas (Ki) tertinggi untuk mendapatkan pilihan terbaik. Data yang digunakan pada penelitian ini berjumlah 30 data perumahan dengan 11 kriteria. Hasil akhir dari penelitian ini menunjukkan bahwa metode EDAS dan ARAS menghasilkan pilihan berbeda pada perangkingan alternatif. Untuk alternatif terbaik pada dengan metode EDAS didapatkan alternatif 9 dengan skor penilaian sebesar 0.7372, sementara dengan metode ARAS alternatif 10 merupakan alternatf terbaik dengan nilai utilitas 1
أغراض الإستفهام بـ "هل" فى الذكر الحكيم
Authors: Nawawi Aksa Muhammad
Published: July 2019

هذا البحث يتحدث عن الاستفهام بــ"هل" فى الذكر الحكيم, يتضمن مبحثين, أما الأول: كيف كانت حقيقة "هل " فى اللغة العربية؟ والثاني: كيف كانت أغراضه فى علم البلاغة وفى الذكر الحكيم؟  فالبحث جار على التحليل البلاغي الكيفي, وتجري على دراسة كتب, ويعنى بها أن المعلومات –بجانب المعلومات التى صدرت من تحليل الكاتب - صادرة من المصادر ا  لمكتوبة– وهى  الكتب – التى تتعلق بموضوع البحث. والمنهج المستخدم أو الطريقة المستخدمة فى البحث هو علوم البلاغة والسياق والمناسبة والنحو والتركيب والتفسير. فالكاتب جعل "هل" فى الذكر الحكيم مادة أولى بالمساعدة على الكتب المتعلقة به لمعرفة الأغراض والأسرار. فالذي يدفعني إلى اختيار هذا الموضوع هو غموض هذا الموضوع. فقد نرى - بنظرة ساطحة - كثيرا فى القران استخدام هذا الأسلوب. فلذلك يحتاج هذا الأسلوب إلى دراسة لفك الغموض وكشف الأسرار. ونتيجة البحث تدل على أسرار ومعاني بلاغية دقيقة لهذا الأسلوب, وأنها تنقسم إلى قسمين: معان رئيسية ومعان فرعية . فالمعاني الرئيسية تنحصرعلى معان أربعة : تقريري, وإنكاري, وطلبي, وعرضي. أما المعاني الفرعية فهي لاتنحصرمنها: التوبيخ والتعجيز والتهكم إلى غير ذلك من المعاني تستنبط من السياق.
FUNGSI KOMUNIKASI ISLAM DI ERA DIGITAL
Authors: Qudratullah Qudratullah
Published: July 2019

Communication is a very important thing in everyday life. Through communication, there is an interaction between communicator and communicant with the aim of achieving an equation. The communication process can be interpreted as an activity of 'transfer information' or message from the sender of the message as a communicator and to the recipient as a communicant. In the communication process aims to achieve mutual understanding between the two parties involved in the communication process. In the process of communication, the communicator sends messages or information to the communicant as the target of communication. In the communication process, it must work as its function. No exception to Islamic communication. The functions of Islamic communication are very important to be implemented so that communication is carried out not only as a process but communicators and communicants can get a good impact. Islamic communication functions are discussed in several parts, namely: information functions, convincing functions, reminding functions, motivating functions, social functions, guidance functions, satisfaction functions, spiritual, and entertainment functions. In the digital era with the rapid development of media, the function is easily applied because it follows the convenience given to communicators and communicants. But there needs to be limitations that must be made so that the functions of Islamic communication that are applied are able to bring benefits to themselves and society in general and avoid things that are not in accordance with the values of religion and culture adopted.
PEMMALI: METODE DAKWAH LELUHUR BUGIS MAKASSAR
Authors: ABIDIN ZAENAL , SAMIN SABRI , AR MOH SABRI
Published: July 2019

This article examines the pemmali as a method of da'wah by Bugis and Makassar ancestors in maintaining the noble values formulated in the cultural system. This study with the dawah approach found that the Bugis and Makassar people always maintained the most fundamental values, namely siri'. This value is at the core of a cultural system called pangadereng. Implementation of Pangangadereng is always maintained and controlled through paseng (warning / tazkirah) or (message / wasiyah) and pemmali or prohibition and prevention. Paseng has a role in directing the implementation of the values of Pangangadereng, while pemmali as an effort to prevent violations against pangngadereng. Paseng in the science of da'wah aims to amar ma'ruf, while pemmali is directed at the nahi munkar. Amar ma'ruf and nahi munkar in the science of da'wah are part of the function of dakwah activities that must be realized. There are various ways of carrying out these functions, including the tanzīr methods. The tanzīr which means a warning against this threat was taken by the ancestors of the Bugis and Makassar people with pemmali
PEMBINGKAIAN BERITA ISU PELEMAHAN RUPIAH MENJELANG PEMILIHAN PRESIDEN 2019 PADA MEDIA ONLINE
Authors: Apriani Marcella
Published: July 2019

The study entitled "Framing of the News Issue of Weakening the Rupiah Ahead of Presidential Election 2019 in Media Online" aims to find out how online media news frames the issue of weakening the rupiah ahead of the presidential election. The news in this study is news that has a high popularity on the issue of the rupiah, namely the period 2 September-8 September 2018. Based on that period, four news were found through the google database. The method in this study is descriptive qualitative research method using the theory of framing analysis of Zhongdang Pan and Gerald M Kosicki. By using four structures from Pan and Kosicki namely syntactic, script, thematic, and rhetorical structures. The results of this study indicate that Kompas.com's online media news framed the news of rupiah depreciation in the political frame, it is seen the use of the word "frying" in quoting statements to describe the rise of the US dollar against the rupiah exchange rate.
Market Research Concerning Functional and Material Solutions Employed in Nursery Facilities
Authors: Radziszewska-Zielina E. , Grabowska W. , Szewczyk B.
Published: July 2019

A great number of non-functional child care facilities for children up to the age of three have been created in Poland to this day. This state of affairs may be the consequence of the low level of knowledge in this field, as well as few available studies on topics associated with nursery facilities, which may familiarise readers with the legal aspects, administrative procedures, or examples of good functional and material solutions of such units. What is more, there is also little information about the needs and preferences of people directly related to the topic. The aim of the article is to analyse the expectations and preferences of nursery facilities’ users in terms of the functional and material solutions. Based on a survey conducted among the nurseries’ employees and parents placing their children in the care of such institutions, a number of guidelines has been defined, allowing for the design of an optimal nursery facility that would meet the market’s expectations.
Prevalence of temporomandibular disorder in Turkish university students: A questionnaire study
Authors: Emel Dervis
Published: July 2019

Background/Aim: Temporomandibular dysfunction (TMD) might influence any individual with different signs and symptoms irrespective of gender or age. The aim of this study is to assess the prevalence of TMD in Oral and Dental Health Program students of İstanbul University-Cerrahpaşa. Material and Methods: This study include a sample of 486 students with age ranging from18 to 24 years. The presence and severity of TMD was evaluated using the Fonseca's Anamnestic Index (FAI) and its questionnaire. The data were analysed using SPSS Version 22. The chisquare test was used to compare the data from different groups and to determine whether the differences were statistically significant. Results: The results showed that a total of 47,53% of students had some degree of TMD and females were generally more affected than males. These degrees were as follows: 33,95 % were classified as mild, 11,52 % moderate and 2,05 % severe signs and symptoms. The women exhibited some degree of TMD (51,8%) at a higher frequency than men (40,33%). No significant differences were observed between gender for a same TMD severity degree (p>0.05). Conclusions: A high prevalence of mild TMD was found in this study population. In addition, tense personalities, headaches, and temporomandibular joint (TMJ) sounds were the most prevalent findings of TMD. The present study suggests that Fonseca's Anamnestic Index (FAI) has been used in screening for TMD for prevention and management of TMD in a non-patient young population.
Assessment of problematic eating behaviour and dental caries in children
Authors: Nembhwani Harsha , Winnier Jasmin
Published: July 2019

Background/Aim: Eating behaviour in children has wide range from anorexia, to selective eating, fussy eater, neophobic/pouching of food & slow eating. Eating behaviour in childhood has been implicated in the development of dental caries and further affecting the body mass index of the child. The aim was to assess the Problematic Eating Behaviour (PEB) and its association with dental caries status of the child. Material and Methods: Parents of 150 children between 3-8 years of age were divided into 2 groups, Group A (3-5 years) and Group B (6-8 years). The parents completed the Children's Eating Behaviour Questionnaire (CEBQ) & the child's dental caries status was recorded. The collected data was subjected to statistical analysis using unpaired t test & Pearson's correlation coefficient test. Results: The results showed that the dental caries status was significantly higher in younger age group (3-5 years) than older age group (6-8 years). Further evaluating the PEB using CEBQ, there was no significant relation found between PEB and dental caries in younger age group of children (3-5 years), but in the older age group (6-8 years) the Factor 4 Desire to Drink (p=0,274) and Factor 5 Satiety Responsiveness (p=0,291) were significantly associated to the dental caries. Conclusions: Eating behaviour can contribute to the development of caries and this has been successfully studied with the use of CEBQ in the present study.
Optical Coherence Tomography-Angiography of Different Choroidal Neovascularization Subtypes in Wet Age-related Macular Degeneration
Authors: Stavrev Vladimir N. , Sivkova Nelly P. , Koleva-Georgieva Desislava N.
Published: July 2019

Age-related macular degeneration is a leading cause of irreversible vision loss in individuals over 55 years of age worldwide. Conventionally, it is divided into two subtypes – dry (non-neovascular) and wet (neovascular) form. Neovascular age-related macular degeneration comprises only 10-15% of all patients but is responsible for more than 80% of blindness related to the disease. It requires early diagnosis and timely treatment. Fluorescein angiography is the current ‘gold standard’ for diagnosing neovascular forms. However, as an invasive procedure, it may be contraindicated in some circumstances and cause serious adverse effects. Optical coherence tomography-angiography is a relatively new, non-invasive and fast imaging modality gaining popularity in the diagnosis of age-related macular degeneration, especially for the neovascular form of the disease. It enables structural and functional information of blood vessels in the retina and choroid, without the need of an intravenous dye. In this study we present and discuss 3 cases of different subtypes of choroidal neovascularization secondary to neovascular age-related macular degeneration. All of them were examined by fluorescein angiography and optical coherence tomography-angiography. The results were qualitatively analyzed.
Role of Fecal Calprotectin as a Noninvasive Indicator for Ulcerative Colitis Disease Activity
Authors: Nakov Radislav V. , Nakov Ventsislav N. , Gerova Vanya A. , Tankova Lyudmila T.
Published: July 2019

Background: It is essential in clinical management to determine the disease activity in ulcerative colitis (UC) patients. At present, the most accurate way of evaluating the UC severity is endoscopy with biopsy. Fecal calprotectin (FCP) is a non-invasive biomarker that is frequently used for monitoring of intestinal inflammation.

Aims: The purpose of our study was to assess the role of FCP as a noninvasive indicator for UC disease activity.

Materials and methods: This prospective study enrolled 116 patients with UC (56 with quiescent UC and 60 with active UC) and 36 controls, referred for colonoscopy to our Center. Colonoscopy was performed in all the patients and the findings were graded according to Mayo endoscopic score (EMS) and UC endoscopic index of severity (UCEIS). FCP was analyzed in stool samples by means of point-of-care desk-top Quantum Blue® method.

Results: There was no significant difference between mean FCP levels in controls and UC patients in remission (р=0.205). Mean FCP in patients with active UC was significantly higher than that in controls (p<0.001) and in patients in remission (p<0.001). FCP significantly correlated with UCEIS (r = 0.869, p<0.001) and EMS (r = 0.814, p<0.001).

Conclusion: The strong correlation with endoscopic disease activity suggests that FCP is a useful biomarker for noninvasive diagnosis and monitoring of disease activity in UC patients.
Temperature-dependent in Situ Gel of Clotrimazole: an Experimental Study
Authors: Patel Vipul P. , Damasiya Harshad M. , Kapupara Pankaj , Ashara Kalpesh C.
Published: July 2019

Background: The in-situ gel-forming polymeric formulations offer sustained and prolonged action in comparison to conventional drug delivery systems.

Aim: To formulate and evaluate in situ vaginal gel of clotrimazole.

Materials and methods: Poloxamer 407 (20%) was slowly added to freezing water (5°C) with constant stirring. The prepared dispersion was refrigerated for 5 h, the different concentrations of polymers were added for preliminary batches. Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were performed for clotrimazole-excipients compatibility study. The final batch was prepared and evaluated for physicochemical parameters, in vitro clotrimazole release, in vitro antifungal activity, and in vivo vaginal tissue irritation test.

Results: The compatibility study showed no chemical interaction between clotrimazole and excipients used. The evaluation parameters showed that clotrimazole release was in the range of 8 to 10 h, gelling temperature was in the range of 27–35°C, gelling time was in the range of 28–34 sec, pH was in the range of 4.4–4.8, and viscosities were in the range of 16.4–182.6 cP (solution form) and 10,500–20,756 cP (gel form). The zone of inhibitions for clotrimazole pure drug, the marketed vaginal gel of clotrimazole, and optimized gel formulation was 9.15±0.75 mm, 14.35±1.12 mm, and 18.85±1.56 mm, respectively (p < 0.0001, q = 5.98). An optimized gel formulation was not irritant to vaginal tissue.

Conclusion: It was possible to formulate effective in situ vaginal gel for control release action of clotrimazole.

Level of Evidence: IIC.
The Epithelial-Mesenchymal Transition, E-cadherin and Tumor Progression in Ovarian Serous Tumors
Authors: Bozhkova Desislava M. , Poryazova-Markova Elena G.
Published: July 2019

Background: The epithelial-mesenchymal transition (EMT), which is a change in the cell phenotype from epithelial to mesenchymal morphology, is an important step in the invasion process and metastasis of ovarian carcinomas. It is known that the suppression of cell adhesion molecules such as E-cadherin and the expression of mesenchymal markers such as Vimentin are key processes in EMT. There is controversy in the literature about the EMT status of ovarian carcinomas.

Aim: To investigate EMT status using immunohistochemical expression of E-cadherin in benign, primary malignant serous ovarian tumors and metastases from them in order to assess their significance in tumor progression.

Materials and methods: The study included a retrospective investigation of 217 ovarian epithelial tumors. Ninety-two cases of serous ovarian tumors and metastases were examined for expression of E-cadherin.

Results: In our study, the predominant histological subtype in benign ovarian tumors and carcinomas was serous (73% and 61%, respectively). 65% of benign tumors demonstrated EMT negative status. The majority of carcinomas demonstrated EMT positive status (82%), whereas negative EMT status was only observed in 18% of cases. 89% of the metastases showed EMT positive status, whereas only 11% of them showed negative EMT status. In 6 selected cases with positive EMT status we found Vimentin expression in tumor cells.

Conclusion: Positive EMT status (reduced E-cadherin expression) is a characteristic of ovarian carcinomas and metastases, but not of benign serous ovarian tumors.
NPS2390, a selective calcium-sensing receptor antagonist controls the phenotypic modulation of hypoxic human pulmonary arterial smooth muscle cells by regulating autophagy
Authors: Peng Xue , Wei Can , Li Hong-Zhu , Li Hong-Xia , Bai Shu-Zhi , Wang Li-Na , Xi Yu-Hui , Yan Jin , Xu Chang-Qing
Published: July 2019

Background and Objectives

Calcium-sensing receptor (CaSR) is known to regulate hypoxia-induced pulmonary hypertension (HPH) and vascular remodeling via the phenotypic modulation of pulmonary arterial smooth muscle cells (PASMCs) in small pulmonary arteries. Moreover, autophagy is an essential modulator of VSMC phenotype. But it is not clear whether CaSR can regulate autophagy involving the phenotypic modulation under hypoxia.

Methods

The viability of human PASMCs was detected by cell cycle and BrdU. The expressions of proliferation protein, phenotypic marker protein, and autophagy protein in human PASMCs were determined by western blot.

Results

Our results showed that hypoxia-induced autophagy was considerable at 24 h. The addition of NPS2390 decreased the expression of autophagy protein and synthetic phenotype marker protein osteopontin and increased the expression of contractile phenotype marker protein SMA-ɑ and calponin via suppressing downstream PI3K/Akt/mTOR signal pathways.

Conclusions

Our study demonstrates that treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.
Unknown use of end-tidal CO2 in metabolic emergencies in pediatric patients
Authors: Redant Sebastien , Angoulvant Francois , Honore Patrick M. , Attou Rachid , Biarent Dominique , Bels David De
Published: July 2019

The authors describe two cases of metabolic acidosis, caused by diabetic ketoacidosis in the first case and by dehydration following gastroenteritis in the second one. Both patients were followed with noninvasive end-tidal CO2 (ETCO2) monitoring. A correlation between EtCO2 and PCO2 and HCO3− has been established in the literature. Noninvasive ETCO2 is used in only 5–6% of metabolic emergencies. In contrast, users described its use as easy and convenient.
Magnetostrictive Vibration Model for Evaluation of Mechanical Integrity of Power Transformer Magnetic Core
Authors: Marks J. , Vitolina S. , Dirba J.
Published: July 2019

Magnetostriction process creates vibrations within magnetic core of a power transformer. This effect can cause delamination of magnetic core layers and increase the vibration amplitudes on the surface of transformer tank. In this paper, a magnetostrictive vibration model is proposed for improved evaluation of the mechanical integrity of magnetic core and the finding of possible mechanical defects. This model is based on the simulation of magnetostrictive vibrations by replacing the magnetic core with mass and spring system, and application of a dynamic genetic algorithm in order to find the necessary system configuration. A case study is provided structurally modelling magnetic core in Matlab and Matlab Simulink with the analysis of simulated vibrations that indicate a possible mechanical defect.
Design of Jack-Up Platform for 6 MW Wind Turbine: Parametric Analysis Based Dimensioning of Platform Legs
Authors: Dymarski Paweł
Published: July 2019

The article presents the results of the research conducted within the framework of the project entitled WIND-TU-PLA (ERA-NET, MARTEC II), the general aim of which was to design and analyse supporting structures for wind turbines intended for operation on the South Baltic area. The research part described in the article aimed at developing a preliminary design for a jack-up platform which can operate on water areas with depth of 40 m. The main task was to determine optimal dimensions of platform legs and the radius of their spacing. Two jack-up platform concepts differing by spacing radius and hull dimensions were designed with the intention to be used as a supporting structure for a 6-MW offshore wind turbine. For each concept, the parametric analysis was performed to determine optimal dimensions of platform legs (diameter Dleg and plating thickness tleg). Relevant calculations were performed to assess the movements of the platform with parameters given in Table 1 in conditions simulating the action of the most violent storm in recent 50 years. The obtained results, having the form of amplitudes of selected physical quantities, are shown in comprehensive charts in Fig. 6 and 7. Based on the critical stress values (corresponding to the yield stress), the area was defined in which the impact strength conditions are satisfied (Fig. 14).

Then, the fatigue strength analysis was performed for two selected critical leg nodes (Fig. 12). Its results were used for defining the acceptable area with respect to structure’s fatigue (Fig. 14). Geometric parameters were determined which meet the adopted criteria, Table 6. The decisive criterion turned out to be the fatigue strength criterion, while the yield point criterion appeared to be an inactive constraint.
Difference in Markers of Microbial Translocation and Cell Apoptosis in HIV Monoinfected and HIV/HCV Coinfected Patients
Authors: Madelāne Monta , Krūmiņa Angelika , Sīmanis Raimonds , Šķenders Ģirts , Ivanovs Andrejs , Stūre Gunta , Vīksna Ludmila
Published: July 2019

Immune activation in human immunodeficiency virus (HIV) infection is driven by microbial translocation and in HIV patients is one of the contributors to faster progression of liver disease along with increased cell apoptosis. The aim of the study was to compare microbial translocation and apoptosis markers in HIV monoinfected and HIV/hepatitis C virus (HCV) coinfected patients, depending on HIV immune status and antiretroviral treatment (ART). We analysed data for 78 HIV monoinfected and 105 HIV/HCV coinfected patients from the Rīga East University Hospital. Lipopolysaccharide (LPS), endotoxin core antibodies (EndoCAb), cytokeratin 18 (CK18) and cyto-chrome c (Cyt-c) levels were measured. No significant difference in LPS, EndoCAb, Cyt-c levels between HIV and HIV/HCV patients was found. The CK18 level was higher in the HIV/HCV group. Correlation between CD4+ cell count and EndoCAb antibodies was found in HCV positive patients. There was a significant effect of ART on markers for EndoCAb IgA and EndoCAb IgM antibodies in the HIV monoinfected group. Correlation between CD4+ cell count and EndoCAb antibodies and LPS was found in HIV/HCV patients on ART. Coinfection with HCV can lead to more pronounced response in EndoCAb antibody production and higher levels of cell apoptosis markers, despite similar LPS levels. ART has a positive effect on immune activation.
Anthropometric Parameters and Biochemical Markers of Military Personnel Under the Influence of High Physical and Psychological Loads
Authors: Pļaviņa Liāna , Mackēvičs Vitolds , Smagare Silva , Čakstiņš Andris , Stankēviča Jekaterina
Published: July 2019

Physical fitness, health, and physical endurance are important attributes of persons in military. The purpose of the present study was to assess the changes of anthropometric parameters and of biochemical markers in blood serum for participants of a one-week combat training course (CTC) during which participants had high physical and psychological loads in combination with dietary limitation and sleep deprivation. High physical and psychological loads cause changes in the level of biochemical markers that are indicative of musculoskeletal system dysfunction. The study group included participants (n = 59) of both genders aged 23 to 30 years. Anthropometric parameters (body mass, height, body mass index) were determined. Blood plasma analyses were done before and directly after CTC. Biomarkers like lactate dehydrogenase (LDH), creatine phosphokinase (CPK), alanine amino transferase (ALT) and aspartate amino transferase (AST) were measured. Data were analysed by using SPSS 20. We determined levels of anthropometric parameters before, during and after a combat training course. The body mass decreased during the one-week training course, until the sixth day of combat training course, when the peak of physical and emotional stress was reached. The level of biomarkers lactate dehydrogenase and creatine phosphokinase sharply increased after the combat training course. A high physical load caused changes in biochemical markers, indicating musculoskeletal dysfunction in healthy young persons. The study underlines the importance of checking the health status of military personnel before and after exercises with high physical and psychological loads in order to prevent major health disorders in the combat environment.
The Influence of Sustainability and Green Management Concepts on Educational Facility Performance in Nigeria
Authors: Femi Oyeyoade Stephen , Araloyin Funmilayo Moyinola
Published: July 2019

This paper investigates the impact of sustainable development and green management on the performance of an educational facility with a view of enhancing the learning environment and increasing students’ achievement in Nigeria. A sequential examination of the benefits of green features and barriers in their adoption was carried out.

The data for the study relied on a study sample of 400 respondents comprising university teachers, “in-resident” building professionals and postgraduate students of a built environment selected from four renowned universities in the south-west region of Nigeria. An ideation framework was constructed and multilevel analysis performed to evaluate perceptions on associated factors alongside the variable items.

The low recognition of basic green benefits by the respondents was, to some extent, the result of unfamiliarity with the discussed concepts. In view of barrier factors deterring the implementation of concepts, the lack of government intervention, unavailability of formulated policies, lack of inclusion of the sustainability concept in the school curricula, and unavailability of capacity training for professionals in the building industry, were perceived to be the prime factors.

The paper concludes that all stakeholders have cogent roles to play at an individual level when it comes to eliminating barriers, initiating concepts, and realizing the desired facility performance capable of ensuring a sustainable learning environment as well as promoting academic excellence in the Nigerian educational sector.
Building Information Modeling for Housing Renovation - Example for Ukraine
Authors: Siniak Nikolai , Źróbek Sabina , Nikolaiev Vsevolod , Shavrov Sergey
Published: July 2019

Building Information Modelling (BIM) is the latest software technology used widely by many construction businesses - big and small - particularly within the Architecture Engineering Construction (AEC) sector. Besides being a design and documentation tool, building information models (BIM) provide a platform for enhanced knowledge base collaboration, the potential to manage modification, and therefore the capability to provide information support throughout the lifecycle of an apartment building. A big share of the eastern European construction industries remains excluded from BIM technology and the potential advantages it will hand over to their business, particularly for renovation projects. It requies the involvement of all stakeholders to realize higher-level coordination, productivity, visualization and value efficiencies. The advantages of BIM exploitation for renovation projects are considered in the article. Tendencies in the development of BIM technologies throughout the globe and in eastern European countries on example of Ukraine are shown. Examples of the exploitation of local building information systems in realizing renovation processes are given, and proposals for policymakers in terms of applying BIM technologies in housing renovation activities and facility management are formulated.
The Determinants of Capital Structure: Evidence from GCC and UK Real Estate Sectors
Authors: Yousef Ibrahim
Published: July 2019

This paper investigates the determinants of capital structure in the context of the Gulf Cooperation Council (GCC) and United Kingdom (UK) real estate sectors. The results of a bivariate analysis indicate that leverage in the UK is much higher than in GCC countries. This may be attributable to UK companies facing a lower cost of debt, which would facilitate their raising of debt capital from the market. In addition, UK real estate firms tend to be larger and have higher levels of tangibility and retained earnings compared with GCC firms, while GCC firms tend to be more profitable and have more growth opportunities. The results of panel and Tobit regression analyses support both trade-off and pecking order theories; for instance, company size was found to have a significant positive impact on different types of debt measurements (market and book debt ratios), which is consistent with the trade-off theory, while profitability and retained earnings to total assets exhibited a significant negative impact for GCC and UK real estate firms, which is consistent with the pecking order theory. Importantly, these results hold true regardless of whether the regressions are estimated using an OLS, random effects, fixed effects panel estimation or a Tobit model.
The neutrophil to lymphocyte ratio in heart failure: a comprehensive review
Authors: Delcea Caterina , Buzea Cătălin Adrian , Dan Gheorghe Andrei
Published: July 2019

Introduction. Heart failure (HF) and systemic inflammation are interdependent processes that continuously potentiate each other. Distinct pathophysiological pathways are activated, resulting in increased neutrophil count and reduced lymphocyte numbers, making the neutrophil to lymphocyte ratio (NLR) a potential indirect marker of severity. We conducted this comprehensive review to characterize the role of NLR in HF.

Methods. We searched the PubMed (MEDLINE) database using the key words “neutrophil”, “lymphocyte”, “heart failure”, “cardiomyopathy”, “implantable cardioverter defibrillator”, “cardiac resynchronization therapy” and “heart transplant”.

Results. We identified 241 publications. 31 were selected for this review, including 12,107 patients. NLR was correlated to HF severity expressed by clinical, biological, and imaging parameters, as well as to short and long-term prognosis. Most studies reported its survival predictive value. Elevated NLR (>2.1–7.6) was an independent predictor of in-hospital mortality [adjusted HR 1.13 (95% CI 1.01–1.27) – 2.8 (95% CI 1.43–5.53)] as well as long-term all-cause mortality [adjusted HR 1.43 (95% CI 1.1–1.85) – 2.403 (95% CI 1.076–5.704)].

Higher NLR levels also predicted poor functional capacity [NLR > 2.26/2.74, HR 3.93 (95% CI 1.02–15.12) / 3.085 (95% CI 1.52–6.26)], hospital readmissions [NLR > 2.9/7.6, HR 1.46 (95% CI 1.10–1.93) / 3.46 (95% CI 2.11–5.68)] cardiac resynchronization therapy efficacy [NLR > 3.45/unit increase, HR 12.22 (95% CI 2.16–69.05) / 1.51 (95% CI 1.01–2.24)] and appropriate implantable cardioverter defibrillator shocks (NLR > 2.93), as well as mortality after left ventricular assist device implantation [NLR > 4.4 / quartiles, HR 1.67 (95% CI 1.03–2.70) / 1.22 (95% CI 1.01–1.47)] or heart transplant (NLR > 2.41, HR 3.403 (95% CI 1.04–11.14)].

Conclusion. Increased NLR in HF patients can be a valuable auxiliary biomarker of severity, and most of all, of poor prognosis.
KONSEP MASHLAHAH DALAM KONSUMSI DITINJAU DARI PERSPEKTIF EKONOMI ISLAM
Authors: Ilyas Rahmat
Published: July 2019

Islamic economics is an integral part (integral) of Islam. As a derivation of Islam, the Islamic economy would follow the method in all aspects. Islam is a system of life (way of life), where Islam has provided a variety of devices complete rules for human life, including in the economic field. Islam positions of economic activities as one of the important aspects to get the glory (Falah), therefore the activity of economic as other activities need to be guided and controlled in order to run harmony with the methods of Islam as a whole. Mashlahah is any goodness dimensional world and hereafter, material and spiritual as well as individual and collective, and it must consist of three elements like adherence of sharia (halal), useful and bring good (Thoyib) in all aspects manner that does not pose a crucial trouble.Ekonomi Islam merupakan bagian yang tidak terpisahkan (integral) dari agama Islam. Sebagai derivasi dari agama Islam, ekonomi islam akan mengikuti ajarannya dalam berabagai aspeknya. Islam adalah sistem kehidupan (way of life), dimana Islam telah menyediakan berbagai perangkat aturan yang lengkap bagi kehidupan manusia, termasuk dalam bidang ekonomi. Islam memposisikan kegiatan ekonomi sebagai salah satu aspek penting untuk mendapatkan kemuliaan (falah), dan karenanya kegiata ekonomi sebagaimana kegiatan lainnya perlu dituntun dan dikontrol agar berjalan seirama dengan ajaran Islam secara keseluruhan. Mashlahah merupakan segala bentuk kebaikan yang berdimensi duniawi dan ukhrawi, material dan spritual serta individual dan kolektif serta harus memenuhi tiga unsur yakni kepatuhan syariah (halal), bermanfaat dan membawa kebaikan (thoyib) dalam semua aspek secara keseluruahn yang tidak menimbulkan kemudharatan.
IMPLEMENTASI PRINSIP-PRINSIP EKONOMI SYARIAH: Alternatif Mewujudkan Kesejahteraan Berkeadilan
Authors: Mursal Mursal
Published: July 2019

One difference between the Islamic economic system with the conventional economic system is a paradigm of life dengaan all akitivitasnya. Islamic economic position as the foundation of belief in doing good activity in social interaction maupn financial transactions. Tawhid is expected to establish the integrity of which will help the formation of a good government. The principle of justice is a necessity in the enforcement of Islamic law. By implementing the principles of economy and Isam in all aspects of economic behavior that justice can be expected welfare terujud. So, so that economic agents do not pursue material gains but also the spiritual.Salah satu perbedaan antara sistem ekonomi Islam dengan sistem ekonomi konvensional adalah paradigma kehidupan dengaan semua akitivitasnya.Posisi ekonomi Islam sebagai dasar keyakinan dalam melakukan aktivitas yang baik dalam interaksi sosial maupun transaksi keuangan. Tauhid diharapkan dapat membentuk integritas yang akan membantu pembentukan pemerintah yang baik. Prinsip keadilan merupakan sebuah keharusan dalam penegakkan syariat Islam.Dengan mengimplementasikan prinsip-prinsip ekonomi Isam dalam semua aspek dan prilaku ekonomi diharapkan kesejahteraan yang berkeadilan dapat terujud.Sehingga, sehingga agen ekonomi tidak mengejar keuntungan materi saja melainkan juga spiritual.