bluuebunny/crossref_metadata_2025 huggingface dataset:
Insider trading: Extracellular matrix proteins and their non‐canonical intracellular roles
Authors: Hellewell Andrew L. , Adams Josephine C.
Published: November 2015

In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneous microenvironment that has important supportive and instructive roles. Although the primary site of action of ECM proteins is extracellular, evidence is emerging for non‐canonical intracellular roles. Examples include osteopontin, thrombospondins, IGF‐binding protein 3 and biglycan, and relate to roles in transcription, cell‐stress responses, autophagy and cancer. These findings pose conceptual problems on how proteins signalled for secretion can be routed to the cytosol or nucleus, or can function in environments with diverse redox, pH and ionic conditions. We review evidence for intracellular locations and functions of ECM proteins, and current knowledge of the mechanisms by which they may enter intracellular compartments. We evaluate the experimental methods that are appropriate to obtain rigorous evidence for intracellular localisation and function. Better insight into this under‐researched topic is needed to decipher the complete spectrum of physiological and pathological roles of ECM proteins.
New directions for protease inhibitors directed drug discovery
Authors: Hamada Yoshio , Kiso Yoshiaki
Published: November 2015

Proteases play crucial roles in various biological processes, and their activities are essential for all living organisms—from viruses to humans. Since their functions are closely associated with many pathogenic mechanisms, their inhibitors or activators are important molecular targets for developing treatments for various diseases. Here, we describe drugs/drug candidates that target proteases, such as malarial plasmepsins, β‐secretase, virus proteases, and dipeptidyl peptidase‐4. Previously, we reported inhibitors of aspartic proteases, such as renin, human immunodeficiency virus type 1 protease, human T‐lymphotropic virus type I protease, plasmepsins, and β‐secretase, as drug candidates for hypertension, adult T‐cell leukaemia, human T‐lymphotropic virus type I‐associated myelopathy, malaria, and Alzheimer's disease. Our inhibitors are also described in this review article as examples of drugs that target proteases. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 563–579, 2016.
Echocardiographic determinants of LV functional improvement after transcatheter aortic valve replacement
Authors: Chen Jinling , Nawaz Nasir , Fox Zachary , Komlo Caroline , Anwaruddin Saif , Desai Nimesh , Jagasia Dinesh , Herrmann Howard C. , Han Yuchi
Published: November 2015

Background

Transcatheter aortic valve replacement (TAVR) is an established therapy in high‐risk patients with severe aortic stenosis. Among patients with reduced left ventricular ejection fraction (LVEF), it is unclear which patients will derive maximal benefit from TAVR.

Methods

Clinical and echocardiographic data of patients with severe aortic stenosis and low LVEF (≤50%) who underwent TAVR at a single institution during 2009–2013 were retrospectively analyzed. Patients were divided into 2 groups post‐TAVR based on improved LV function (Group A = ΔLVEF ≥ 10%) versus persistent LV dysfunction (Group B = ΔLVEF<10%). Echocardiographic parameters were assessed for their association with LVEF change post‐TAVR. Kaplan–Meier analysis was performed to generate survival estimates.

Results

Of 382 patients who underwent TAVR, 60 patients had low LVEF, LV function failed to improve ≥10% in 50% of patients following the procedure (Group B). At baseline echocardiograms, Group B had higher LVEF, stroke volume (SV), SV index; and lower E, E/E′, and estimated pulmonary arterial systolic pressure (PASP) compared to Group A. Higher mortality was found in Group B compared to the Group A (p = 0.003) with a significantly shorter survival (Group A = 3.3 ± 0.1 years vs Group B = 2.7 ± 0.2 years, p = 0.003). One‐year event free survival was 53.3% in Group B compared to 93.3% in Group A, with a stable trend over ensuing years (5‐year survival; 53.3% versus 90.0%, p = 0.003).

Conclusions

In patients undergoing TAVR with depressed LV function, those who failed to improve were more likely to have relatively higher LVEF, SV, and SVI; and lower E, E/E′, and PASP at baseline. Mortality rates were found to be higher in persistent LV dysfunction group. © 2015 Wiley Periodicals, Inc.
AVERTing contrast nephropathy—delivering less to get more?
Authors: Seto Arnold H. , Kern Morton J.
Published: November 2015

Key Points

Delivered contrast volume is the major modifiable risk factor for contrast nephropathy.

The AVERT system can divert 31–40% of contrast for peripheral angiography.

The upcoming results of the AVERT clinical trial will demonstrate whether the AVERT system reduces contrast nephropathy.
Contrast does not lie, but can we see the true?
Authors: Gilchrist Ian C.
Published: November 2015

Key Points

The ability to estimate true length in the coronary artery by simple visual inspection appears to be as inaccurate as estimates of coronary stenosis.

Recognizing this physician‐related factor may play a roll in correct choice of stent length and thereby effect procedural outcome is the first step in improving results.

Further work is needed on how adjunctive equipment with reference markers such as wires or balloons may improve on the estimate of length is needed.
One step forward or eight needles back: A retro(grade) approach to femoral hemostasis for TAVR
Authors: Turi Zoltan G.
Published: November 2015

Key points

Percutaneous approach rather than surgical cutdown is the procedure of choice for TAVR patients to minimize morbidity and procedure time.

ProGlide has been shown to have noninferior outcomes versus surgical cutdown with shorter procedure time and less pain; noninferiority was not demonstrated by single Prostar XL in a randomized trial of “preclosure” for endovascular aortic aneurysm repair. The current study did not include a ProGlide arm.

As the size of Transcatheter Aortic Valve Replacement devices continues to decrease, the need for large bulky 4‐needle devices like the Prostar XL is likely to become obsolete.
Isodicentric Philadelphia chromosome: an uncommon chromosomal abnormality in the chronic phase of chronic myeloid leukemia (CML)
Authors: Loo Eric , Bansal Pranshu , Cherukuri Durga , Arana Yi Cecilia
Published: November 2015

Key Clinical Message

An isodicentric Philadelphia chromosome is an uncommon finding previously described as a secondary chromosomal abnormality in accelerated‐ or blast‐phase of chronic myeloid leukemia (CML) with resistance to imatinib mesylate or dasatinib. Here, we present a case with idic(Ph) chromosome identified at initial diagnosis in a patient with chronic‐phase CML.
Thigh compartment syndrome complicated by sciatic nerve palsy, rhabdomyolysis, and acute renal failure
Authors: Alobaidi Ahmad , Backdash Mohamad Munir , El‐Menyar Ayman
Published: November 2015

Key Clinical Message

We reported a rare case of thigh compartment syndrome (TCS) complicated by sciatic nerve palsy, rhabdomyolysis, and acute renal failure in an alcoholic patient. Intensive care measures and immediate posteromedial decompressive fasciotomy were performed. These timely interventions resulted in improvement of the nerve injury and restoration of the kidney function.
Vacuolated lymphocytes signifying a metabolic disorder in an infant with developmental delay
Authors: Salama Rasha , Zhou Jiehao
Published: November 2015

Key Clinical Message

Metabolic disorders sometimes cause accumulation of metabolic byproducts which are manifested as cytoplasmic vacuoles in lymphocytes. We report the case of an infant with final diagnosis of GM1 gangliosidosis who initially presented with developmental delay and peripheral blood vacuolated lymphocytes. Blood film review is recommended in children suspicious for metabolic disorders.
Carbon Dioxide/Epoxide Reactions Catalyzed by Bimetallic Salalen Aluminum Complexes
Authors: Cozzolino Mariachiara , Press Konstantin , Mazzeo Mina , Lamberti Marina
Published: November 2015

Four new bimetallic aluminum complexes that bear salalen ligands were synthesized and characterized. They were employed as catalysts in the reaction of CO2 with both cyclohexene oxide and propylene oxide with tetrabutyl ammonium bromide as the cocatalyst. The effect of the reaction conditions on the productivity and selectivity of the catalytic system was evaluated. Under the optimized reaction conditions, cis‐cyclohexene carbonate and propylene carbonate were obtained as exclusive products, respectively. Interestingly, in the production of cis‐cyclohexene carbonate, turnover frequencies comparable to those of the most active systems described in the literature were obtained. Moreover the catalytic system was active even if it was operated at a low CO2 pressure (0.2 MPa) and with a low catalyst loading (0.04 mol %).
Alkylaminophosphazenes as Efficient and Tuneable Phase‐Transfer Agents for Polyoxometalate‐Catalysed Biphasic Oxidation with Hydrogen Peroxide
Authors: Craven Michael , Yahya Rana , Kozhevnikova Elena F. , Robertson Craig M. , Steiner Alexander , Kozhevnikov Ivan V.
Published: November 2015

Alkylaminophosphazenes (RPN) are efficient and tuneable phase‐transfer agents for environmentally benign biphasic oxidation with hydrogen peroxide catalysed by polyoxometalates (POMs). Substituent groups on the phosphazene ring can be varied to modify the phase‐transfer efficiency of RPN for use in water–organic two‐phase systems. Active phosphazene–polyoxometalate aggregates that self‐assemble in situ from RPN and Keggin POMs, such as PMo12O403−and PW12O403−, were found to be efficient and recyclable catalysts for the oxidation of benzothiophenes and the epoxidation of alkenes with hydrogen peroxide. Lipophilic phosphazene cations present in these aggregates render the POM soluble in organic media. Catalyst activity in the biphasic oxidation with H2O2varies with the RPN substituent alkylamino groups with respect to the solvent system used. The activity decreases in the series of POMs: PMo12O403−>PW12O403−≫SiW12O404−irrespective of the solvent system used.
ChemInform Abstract: Structural Transformation Between Two Cubic Phases of (NH4)3SnF7.
Authors: Flerov I. N. , Molokeev M. S. , Laptash N. M. , Udovenko A. A. , Pogoreltsev E. I. , Mel'nikova S. V. , Misyul S. V.
Published: November 2015

Single crystals of (NH4)3SnF7 are obtained from aqueous solutions of (NH4)2SnF6 and excess NH4F during solvent evaporation.
ChemInform Abstract: Ca4Au10Zn3 — A Substitution Variant of AlB2 by Incorporation of Zn3 Triangles.
Authors: Gerke Birgit , Hoffmann Rolf‐Dieter , Poettgen Rainer
Published: November 2015

Single crystals of the title compound are selected from high‐frequency melts of the elements in stoichiometric ratio with a 5 at.% Zn excess (sealed Ta ampoules, 925 K, 3 h).
ChemInform Abstract: Syntheses, Crystal Structures, and Electronic Properties of Ba8Si2US14 and Ba8SiFeUS14.
Authors: Mesbah Adel , Prakash Jai , Lebegue Sebastien , Stojko Wojciech , Ibers James A.
Published: November 2015

Black single crystals of the new title compounds are prepared using U, Rb2S3, BaS, and S as starting materials (silica tubes, 1223 K, 96‐192 h, ≈5% yield).
ChemInform Abstract: Synthesis, Crystal Structure and Electrical Properties of a New Iron Arsenate Na2.77K1.52Fe2.57 (AsO4)4.
Authors: Ouerfelli Najoua , Ben Smida Youssef , Zid Mohamed Faouzi
Published: November 2015

Single crystals of Na2.77K1.52Fe2.57 (AsO4)4 are prepared by solid state reaction of a 1:1:1:5 molar mixture of Na2CO3, K2CO3, Fe(NO3)3, and NH4H2AsO4 (Pt crucible, 1.
ChemInform Abstract: Asymmetric Reduction of Imines with Trichlorosilane Catalyzed by Valine‐Derived Formamide Immobilized onto Magnetic Nano‐Fe3O4.
Authors: Ge Xin , Qian Chao , Ye Xiaoming , Chen Xinzhi
Published: November 2015

Formyl‐valine containing iron oxide/silica nanoparticles catalyze the asymmetric reduction of imines.
ChemInform Abstract: First Regioselective Iodocyclization Reaction of 3‐Aryl‐5‐(prop‐2‐ynylthio)‐1H‐1,2,4‐triazoles.
Authors: Rode Navnath D. , Sonawane Amol D. , Garud Dinesh R. , Joshi Rohini R. , Joshi Ramesh A. , Likhite Anjali P.
Published: November 2015

Iodocyclization of substrates (I) using molecular iodine followed by copper‐catalyzed intramolecular C—N coupling affords triazolothiazines (III).
ChemInform Abstract: Facile Route to 2‐Fluoropyridines via 2‐Pyridyltrialkylammonium Salts Prepared from Pyridine N‐Oxides and Application to 18F‐Labeling.
Authors: Xiong Hui , Hoye Adam T. , Fan Kuo‐Hsien , Li Ximin , Clemens Jennifer , Horchler Carey L. , Lim Nathaniel C. , Attardo Giorgio
Published: November 2015

Starting from pyridine N‐oxides the formation of various 2‐trialkylammonium salts is examined.
ChemInform Abstract: Latent Ruthenium—Indenylidene Catalysts Bearing a N‐Heterocyclic Carbene and a Bidentate Picolinate Ligand.
Authors: Schmid Thibault E , Modicom Florian , Dumas Adrien , Borre Etienne , Toupet Loic , Basle Olivier , Mauduit Marc
Published: November 2015

From a set of three novel precatalysts compound RIC gives the best results in ring‐closing, cross‐ and enyne metathesis reactions.
ChemInform Abstract: RhIII‐Catalyzed Olefination of 2‐Aryloxypyridines Using 2‐Pyridyloxyl as the Removable Directing Group.
Authors: Borah Arun Jyoti , Yan Guobing , Wang Lianggui
Published: November 2015

Acrylates, acrylamide and styrenes can be used in the title reaction.
ChemInform Abstract: Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by Aziridine Carbinols.
Authors: Wang Xiaojuan , Zhao Wenxian , Li Gaowei , Liu Guanjun , Wang Jin , Wang Mincan , Liu Lantao
Published: November 2015

The enantiopure aziridine carbinol ligands are easily prepared in five steps from commercially available starting materials and successfully used as catalyst in the synthesis of chiral secondary alcohols.
ChemInform Abstract: Oxidation of Benzyl Alcohols to Benzaldehydes in Water Catalyzed by a Cu(II) Complex with a Zwitterionic Calix[4]arene Ligand.
Authors: Gao Jun , Ren Zhi‐Gang , Lang Jian‐Ping
Published: November 2015

The use of the Cu‐calixarene complex (CAL) in combination with TEMPO allows a high yielding oxidation of benzylic alcohols to the corresponding aldehydes with hydrogen peroxide as the oxidant.
ChemInform Abstract: Copper(II)‐Triflate‐Catalyzed Oxidative Amidation of Terminal Alkynes: A General Approach to α‐Ketoamides.
Authors: Kumar Manjeet , Devari Shekaraiah , Kumar Arvind , Sultan Shaista , Ahmed Qazi Naveed , Rizvi Masood , Shah Bhahwal Ali
Published: November 2015

In the presence of atmospheric oxygen, secondary and primary amines can be used in the title process.
ChemInform Abstract: N‐Heterocyclic‐Carbene‐Catalyzed Sulfa‐Michael Additions.
Authors: Li Yuan‐Zhen , Wang Ying , Du Guang‐Fen , Zhang Hai‐Yan , Yang Hong‐Li , He Lin
Published: November 2015

The mild procedure tolerates various functionalities in the unsaturated ketone substrates and affords the required β‐keto sulfides in generally high yields.
ChemInform Abstract: Bismuth(III)‐Promoted Acetylation of Thioethers into Thioacetates.
Authors: Jevric Martyn , Petersen Anne Ugleholdt , Mansoe Mads , Madsen Anders Oestergaard , Nielsen Mogens Broendsted
Published: November 2015

A convenient method is found which allows the conversion of tBu‐thioethers to thioacetates, an important function in various fields of chemistry.
ChemInform Abstract: An Efficient Electrochemical Synthesis of β‐Keto Sulfones from Sulfinates and 1,3‐Dicarbonyl Compounds.
Authors: Pan Xiao‐Jun , Gao Jian , Yuan Gao‐Qing
Published: November 2015

β‐Keto sulfones are synthesized through an electrochemical route by using ammonium iodide as the supporting electrolyte.
ChemInform Abstract: Palladium/Copper‐Cocatalyzed Oxidative Amidobrominations of Alkenes.
Authors: Chen Xiao Yun , Bohmann Rebekka Anna , Wang Long , Dong Shunxi , Raeuber Christoph , Bolm Carsten
Published: November 2015

The procedure allows a difunctionalization of the starting alkenes in a highly selective manner (reaction mechanism).
ChemInform Abstract: A Highly Active and Easily Accessible Cobalt Catalyst for Selective Hydrogenation of C=O Bonds.
Authors: Roesler Sina , Obenauf Johannes , Kempe Rhett
Published: November 2015

The newly developed catalyst is successfully applied in the hydrogenation of aryl/hetaryl‐alkyl, diaryl, and dialkyl substituted ketones as well as benzaldehydes.
ChemInform Abstract: Application of Quinoxaline Based Diimidazolium Salt in Palladium Catalyzed Cross‐Coupling Reactions.
Authors: Siddiqui Mujahuddin M. , Waheed Mohammed , Bhat Sajad A. , Balakrishna Maravanji S.
Published: November 2015

The title diimidazolium salt was used together with Pd(OAc)2 to catalyze Suzuki—Miyaura and Heck reactions.
ChemInform Abstract: The Reaction of 2,3‐Dimethylimidazole‐1‐sulfonyl Azide Triflate with 3‐Substituted Indoles: Reactivity and Scope.
Authors: Shen Mei‐Hua , Xu Ke , Sun Chu‐Han , Xu Hua‐Dong
Published: November 2015

The title reaction provides imidazolium intermediates which are trapped with alcohols or amines and, depending on the conditions, 2‐iminoindolines, 2‐aminoindoles, 2‐imino‐3‐aminoindolines or spiroindoline architectures may be obtained.
ChemInform Abstract: Catalyst‐Free and Oxidant‐Free Synthesis of 1,3,5‐Trisubstituted Pyrazoles by Michael‐Type Addition of Hydrazone sp2 Nitrogen Atoms to Enones.
Authors: Zhu Chunyin , Bi Benwei , Yao Dewei , Chen Qiu‐Yun , Luo Zhi‐Bin
Published: November 2015

The title synthesis shows good compatibility with both α‐ester‐ and α‐keto‐substituted hydrazones [e.g. (IIa) and (IIb)], but it doesn′t apply to alkyl substituted enones, e.g. butane‐2,3‐dione.
ChemInform Abstract: Synthesis and Antimicrobial Evaluation of Some New 4,5′‐Bisthiazoles.
Authors: Rozsa Tibor , Duma Mihaela , Vlase Laurian , Ionut Ioana , Pirnau Adrian , Tiperciuc Brindusa , Oniga Ovidiu
Published: November 2015

All synthesized compounds are found to show moderate to very good antifungal activity against C.
ChemInform Abstract: Regioselective Cross‐Couplings of Coumarins and Flavones with Ethers via C(sp3)—H Functionalization.
Authors: Niu Ben , Zhao Wannian , Ding Yingcai , Bian Zhaogang , Pittman Charles U. , Zhou Aihua , Ge Haibo
Published: November 2015

A radical cross‐coupling reaction of coumarins and flavones with acyclic and cyclic alkyl ethers yields the corresponding α‐ and β‐(alkoxyalkyl) derivatives, respectively.
ChemInform Abstract: Synthesis of C4—C5 Cycloalkyl‐Fused and C6‐Modified Chromans via ortho‐Quinone Methides.
Authors: Tangdenpaisal Kassrin , Chuayboonsong Kanokpish , Sukjarean Patchaya , Katesampao Varisa , Noiphrom Nok , Ruchirawat Somsak , Ploypradith Poonsakdi
Published: November 2015

The title chromans are synthesized via ortho‐quinone methides/hetero‐Diels—Alder reactions.
ChemInform Abstract: 9‐Aryl Substituted Hydroxylated Xanthen‐3‐ones: Synthesis, Structure and Antioxidant Potency Evaluation.
Authors: Veljovic Elma , Spirtovic‐Halilovic Selma , Muratovic Samija , Valek Zulj Lidija , Roca Suncica , Trifunovic Snezana , Osmanovic Amar , Zavrsnik Davorka
Published: November 2015

Ten 9‐aryl substituted hydroxylated xanthen‐3‐ones, including three new compounds (III) are synthesized using a reliable one‐pot synthesis.
ChemInform Abstract: Nano‐TiCl4/SiO2: An Efficient Heterogeneous Solid Acid Catalyst for the One Pot Cascade Five‐Component Synthesis of Densely Functionalized Tetrahydropyridines.
Authors: Bamoniri Abdolhamid , Mirjalili Bi Bi Fatemeh , Tarazian Reza
Published: November 2015

The tetrahydropyridines are synthesized from para‐substituted anilines, aromatic aldehydes, and ethyl acetoacetate using the title inexpensive catalyst under thermal conditions.
ChemInform Abstract: First Report of Multiple Metal Ions Containing Glass—Ceramic Material as a Heterogeneous Ditopic Catalyst for the Chromatography Free Synthesis of 2‐Amino‐3,5‐dicarbonitrile‐6‐arylthio‐pyridines in Water.
Authors: Manna Priyabrata , Maiti P. K.
Published: November 2015

The title glass‐ceramic material is synthesized and utilized as catalyst for the three‐component condensation of aldehydes, thiols, and malononitrile.
ChemInform Abstract: The Convenient Synthesis of 11‐Methyl‐3,8‐disubstituted‐12‐aryl‐3,4,7,8,9,12‐hexahydro‐1H‐chromeno [2,3‐b]quinoline‐1,10(2H)‐dione Derivatives.
Authors: Han Guang‐Fan , Zhao Li‐Jun , Chen Li‐Zhuang , Du Jia‐Wei , Wang Zhong‐Xia
Published: November 2015

Arylidene‐3‐oxobutanenitrile derivatives (III) prepared by Knoevenagel condensation of aldehydes with 3‐oxobutanenitrile, react with cyclohexanedione in ethylene glycol to give benzopyran derivatives (V).
ChemInform Abstract: Quinoline Alkaloids — Synthesis, Molecular Docking Studies of Atanine, 2‐Isopropylfuro[2,3‐b]quinolines and 3,4‐Dihydro‐2,2‐dimethyl‐2H‐pyrano[2,3‐b]quinolines.
Authors: Satheeshkumar R. , Kavitha C. , Muthusankar A. , Shanmughavel P. , Prasad K. J. Rajendra
Published: November 2015

The novel and efficient synthetic route to the title compounds involves a decarboxylation reaction leading to atanine (IV) followed either by Prevost′s reaction affording furoquinolines (II) or by cyclization with a few drops of conc.
ChemInform Abstract: One‐Step Synthesis of Alkyl 2‐Chloropyrimido[1,2‐a]benzimidazole‐3‐carboxylates under Catalyst‐Free: Combined Experimental and Computational Studies.
Authors: Liu Yang , Xia Guoming , Luo Chao , Sun Jianqi , Ye Benfei , Yuan Yanli , Wang Hongming
Published: November 2015

The title species (IV) are prepared through a facile one‐pot reaction of substrates (I) and (II) with alcohols.
ChemInform Abstract: Identification and Antifeedant Activities of Limonoids from Azadirachta indica.
Authors: Yan Yu‐Xin , Liu Jie‐Qing , Wang Hong‐Wei , Chen Jin‐Xiong , Chen Jian‐Chao , Chen Li , Zhou Lin , Qiu Ming‐Hua
Published: November 2015

isolation and structure elucidation of four new limonoids, azadiraindins A—D from neem tree Azadirachta indica
ChemInform Abstract: Synthesis of Magnetic and Multiferroic Materials from Polyvinyl Alcohol‐Based Gels
Authors: Lisnevskaya I. V. , Bobrova I. A. , Lupeiko T. G.
Published: November 2015

Review: 50 refs.
ChemInform Abstract: Magnetic Interactions: a Tool to Modify the Magnetic Properties of Materials Based on Nanoparticles
Authors: Peddis Davide , Joensson Petra F. , Laureti Sara , Varvaro Gaspare
Published: November 2015

Review: 190 refs.
ChemInform Abstract: Rhenium(V) Oxocomplexes [ReOX(N‐O)2] and [ReOL(N‐O)2]+‐Synthesis, Structure, Spectroscopy and Catalytic Properties
Authors: Machura Barbara , Wolff Mariusz , Gryca Izabela
Published: November 2015

Review: 51 refs.
ChemInform Abstract: Biomimicry in Metal‐Organic Materials
Authors: Zhang Muwei , Gu Zhi‐Yuan , Bosch Mathieu , Perry Zachary , Zhou Hong‐Cai
Published: November 2015

Review: 309 refs.
ChemInform Abstract: Diarylplatinum(II) Compounds as Versatile Metallating Agents in the Synthesis of Cyclometallated Platinum Compounds with N‐Donor Ligands
Authors: Crespo Margarita
Published: November 2015

Review: 72 refs.
ChemInform Abstract: An Overview of Reductive Trifluoromethylation Reactions Using Electrophilic ′+CF3′ Reagents
Authors: Wang Shi‐Meng , Han Jia‐Bin , Zhang Cheng‐Pan , Qin Hua‐Li , Xiao Ji‐Chang
Published: November 2015

Review: [66 refs.
ChemInform Abstract: Advances in Immobilized Organocatalysts for the Heterogeneous Asymmetric Direct Aldol Reactions
Authors: Bartok Mihaly
Published: November 2015

Review: 188 refs.
ChemInform Abstract: Solid Base Catalysts: Fundamentals and Their Applications in Organic Reactions
Authors: Hattori Hideshi
Published: November 2015

Review: 33 refs.
ChemInform Abstract: The Activation Strain Model and Molecular Orbital Theory
Authors: Wolters Lando P. , Bickelhaupt F. Matthias
Published: November 2015

Review: 144 refs.
Treatment of Stable Angina Pectoris With Ivabradine in Everyday Practice: A Pan‐Hellenic, Prospective, Noninterventional Study
Authors: Zarifis John , Grammatikou Violetta , Kallistratos Manolis , Katsivas Apostolos ,   on Behalf of the Investigators of the Prospective, Noninterventional, Observational Study of the Antianginal Efficacy of Ivabradine During a 4‐Month Treatment of a Greek Population With Coronary Artery Disease
Published: November 2015

Introduction

In coronary artery disease (CAD), medical treatment is the main clinical strategy for controlling ischemia and angina symptoms while restoring a satisfactory level of usual activities and improving quality of life (QOL). This study's purpose was to evaluate in CAD patients the antianginal efficacy of 4‐month treatment with ivabradine plus a β‐blocker and to record patient compliance and the effect of treatment on QOL.

Methods

In this noninterventional study, 2403 patients with chronic stable angina were prospectively studied from 245 private cardiology offices. Data were recorded at baseline and at 1 and 4 months after inclusion. Patient quality of life was assessed using the EuroQol 5 dimensions (EQ‐5D) questionnaire.

Results

From baseline to study completion, mean heart rate decreased from 81.5 ± 9.7 bpm to 63.9 ± 6.0 bpm (P <‐0.001), mean number of anginal attacks decreased from 2.0 ± 2.0 times/wk to 0.2 ± 0.6 times/wk (P < 0.001) and nitroglycerin consumption decreased from 1.4 ± 2.0 times/wk to 0.1 ± 0.4 times/wk (P < 0.001). The percentage of patients with Canadian Cardiovascular Society angina class I increased from approximately 38% (baseline) to 84% (study completion; P < 0.001). The reduction in anginal attacks, nitroglycerin consumption, and angina score was correlated with reduction in heart rate (P < 0.001). The mean EQ‐5D visual analogue scale index increased by 16.1 points (P < 0.001), and compliance with treatment was high throughout the trial (96%).

Conclusions

Ivabradine administration on top of optimal individualized dose of β‐blockers is associated with decreased anginal events and with improvement of QOL in CAD patients.
Development of Polar Order in the Liquid Crystal Phases of a 4‐Cyanoresorcinol‐Based Bent‐Core Mesogen with Fluorinated Azobenzene Wings
Authors: Alaasar Mohamed , Prehm Marko , Tamba Maria‐Gabriela , Sebastián Nerea , Eremin Alexey , Tschierske Carsten
Published: November 2015

A bent‐core mesogen consisting of a 4‐cyanoresorcinol unit as the central core and laterally fluorinated azobenzene wings forms four different smectic LC phase structures in the sequence SmA–SmCs–SmCsPAR–M, all involving polar SmCsPS domains with growing coherence length of tilt and polar order on decreasing temperature. The SmA phase is a cluster‐type de Vries phase with randomized tilt and polar direction; in the paraelectric SmCs phase the tilt becomes uniform, although polar order is still short‐range. Increasing polar correlation leads to a new tilted and randomized polar smectic phase with antipolar correlation between the domains (SmCsPAR) which then transforms into a viscous polar mesophase M. As another interesting feature, spontaneous symmetry breaking by formation of a conglomerate of chiral domains is observed in the non‐polar paraelectric SmCs phase.
Metal‐organic CVD of Y2O3 Thin Films using Yttrium tris‐amidinates
Authors: Karle Sarah , Dang Van‐Son , Prenzel Marina , Rogalla Detlef , Becker Hans‐Werner , Devi Anjana
Published: November 2015

Thin films of Y2O3 are deposited on Si(100) and Al2O3 (0001) substrates via metal‐organic (MO)CVD for the first time using two closely related yttrium tris‐amidinate compounds as precursors in the presence of oxygen in the temperature range 400–700 °C. The structural, morphological, and compositional features of the films are investigated in detail. At deposition temperatures of 500 °C and higher both the precursors yield polycrystalline Y2O3 thin films in the cubic phase. The compositional analysis revealed the formation of nearly stoichiometric Y2O3. The optical band gaps are estimated using UV‐Vis spectroscopy. Preliminary electrical measurements are performed in the form of a metal oxide semiconductor (MOS) structure of Al/Y2O3/p‐Si/Ag. Leakage currents and dielectric constants are also determined.
Flow cytometric analysis of CD200 expression by pulmonary small cell carcinoma
Authors: Bohling Sandra D. , Davis Evan , Thompson Kimberly , Kussick Steven J. , Love Jason
Published: November 2015

Background

CD200 is a membrane bound glycoprotein that is expressed by a variety of normal tissues and hematopoietic malignancies. Flow cytometric analysis of CD200 expression has utility in the evaluation of mature B‐cell neoplasms, myeloma, and acute leukemia; however, CD200 expression in nonhematopoietic malignancies has not been extensively studied.

Methods

We studied 14 cases of biopsy proven pulmonary small cell carcinoma in which a discrete CD45 negative, CD56 positive abnormal cell population was identified by flow cytometry. We retrospectively evaluated these cases for flow cytometric and immunohistochemical evidence of CD200 expression.

Results

Twelve of the 14 cases of pulmonary small cell carcinoma showed convincing expression of CD200 by both immunohistochemistry and flow cytometry.

Conclusions

Pulmonary small cell carcinoma frequently expresses CD200 at a level that can be detected by flow cytometry and immunohistochemistry. CD200 expression therefore may be used to help identify pulmonary small cell carcinoma in flow cytometry specimens and tissue sections. CD200 may also play a role in the biology of pulmonary small cell carcinoma and is a potential target of future therapies. © 2015 International Clinical Cytometry Society
Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal‐Retzius cells
Authors: Barber Melissa , Pierani Alessandra
Published: November 2015

Tangential migration is a mode of cell movement, which in the developing cerebral cortex, is defined by displacement parallel to the ventricular surface and orthogonal to the radial glial fibers. This mode of long‐range migration is a strategy by which distinct neuronal classes generated from spatially and molecularly distinct origins can integrate to form appropriate neural circuits within the cortical plate. While it was previously believed that only GABAergic cortical interneurons migrate tangentially from their origins in the subpallial ganglionic eminences to integrate in the cortical plate, it is now known that transient populations of glutamatergic neurons also adopt this mode of migration. These include Cajal‐Retzius cells (CRs), subplate neurons (SPs), and cortical plate transient neurons (CPTs), which have crucial roles in orchestrating the radial and tangential development of the embryonic cerebral cortex in a noncell‐autonomous manner. While CRs have been extensively studied, it is only in the last decade that the molecular mechanisms governing their tangential migration have begun to be elucidated. To date, the mechanisms of SPs and CPTs tangential migration remain unknown. We therefore review the known signaling pathways, which regulate parameters of CRs migration including their motility, contact‐redistribution and adhesion to the pial surface, and discuss this in the context of how CR migration may regulate their signaling activity in a spatial and temporal manner. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 847–881, 2016
Hybridization of cultivated Vitis vinifera with wild V. californica and V. girdiana in California
Authors: Dangl Gerald S. , Mendum Mary Lou , Yang Judy , Walker M. Andrew , Preece John E.
Published: November 2015

Hybridization of introduced domesticates and closely related natives is well documented in annual crops. The widespread introduction of the domesticated grapevine, Vitis vinifera, into California where it overlaps with two native congenerics, with which it is interfertile, provides opportunity to investigate hybridization between woody perennials. Although geographically widespread, the introduction over the past two centuries has been limited to a few elite clonal cultivars, providing a unique opportunity to study the effects of hybridization on the native species. The amount of hybridization with V. vinifera and the genetic diversity of wild‐growing Vitis californica and Vitis girdiana were examined using nineteen microsatellite markers. STRUCTURE analysis was used to define hybrid and introgressed individuals and to analyze genetic structure of the native species. FAMOZ software was used to identify which V. vinifera cultivars served as parents of F1 hybrids. The three species were clearly distinguished by STRUCTURE analysis. Thirty percent of 119 V. californica vines were hybrids. The domesticated parent was identified for 16 F1 hybrid vines; the original California cultivar, ‘Mission’, was the parent of eight. Backcrosses were also found, showing introgression into subsequent generations. Similar results were obtained for a small sample of V. girdiana. Removing hybrids greatly reduced the genetic variation of the presumed pure species, among which there was essentially no genetic structure. Limited genetic variability indicates the California natives may be threatened by genetic erosion. The discovery of F1 hybrids of ‘Mission’, a cultivar not grown in the areas for ~100 years, suggests long generation times for wild vines that, often, grow into expansive liana and propagate by layering, all factors that limit recruitment in populations already disjunct by habitat lose. Hermaphroditic flowers and fruit that is more attractive to birds may favor the production of backcross seed and establishment of introgressed individuals.
Determining habitat quality for species that demonstrate dynamic habitat selection
Authors: Beerens James M. , Frederick Peter C. , Noonburg Erik G. , Gawlik Dale E.
Published: November 2015

Determining habitat quality for wildlife populations requires relating a species' habitat to its survival and reproduction. Within a season, species occurrence and density can be disconnected from measures of habitat quality when resources are highly seasonal, unpredictable over time, and patchy. Here we establish an explicit link among dynamic selection of changing resources, spatio‐temporal species distributions, and fitness for predictive abundance and occurrence models that are used for short‐term water management and long‐term restoration planning. We used the wading bird distribution and evaluation models (WADEM) that estimate (1) daily changes in selection across resource gradients, (2) landscape abundance of flocks and individuals, (3) conspecific foraging aggregation, and (4) resource unit occurrence (at fixed 400 m cells) to quantify habitat quality and its consequences on reproduction for wetland indicator species. We linked maximum annual numbers of nests detected across the study area and nesting success of Great Egrets (Ardea alba), White Ibises (Eudocimus albus), and Wood Storks (Mycteria americana) over a 20‐year period to estimated daily dynamics of food resources produced by WADEM over a 7490 km2 area. For all species, increases in predicted species abundance in March and high abundance in April were strongly linked to breeding responses. Great Egret nesting effort and success were higher when birds also showed greater conspecific foraging aggregation. Synthesis and applications: This study provides the first empirical evidence that dynamic habitat selection processes and distributions of wading birds over environmental gradients are linked with reproductive measures over periods of decades. Further, predictor variables at a variety of temporal (daily‐multiannual) resolutions and spatial (400 m to regional) scales effectively explained variation in ecological processes that change habitat quality. The process used here allows managers to develop short‐ and long‐term conservation strategies that (1) consider flexible behavioral patterns and (2) are robust to environmental variation over time.
Seasonal and urban effects on the endocrinology of a wild passerine
Authors: Russ Anja , Reitemeier Susanne , Weissmann Anne , Gottschalk Jutta , Einspanier Almuth , Klenke Reinhard
Published: November 2015

In order to maximize their fitness, organisms in seasonal environments rely on external cues to optimally time their life‐history stages. One of the most important zeitgeber to time reproduction is the photoperiod, but further environmental cues are assessed to fine‐tune reproduction due to year‐to‐year variation in environmental conditions. However, in urbanized environments, the pervasive artificial light at night has altered the natural signal of light and darkness. Accordingly, artificial light at night was repeatedly shown to affect avian reproductive physiology and to advance seasonal reproduction in birds. However, these experiments were mainly conducted in the absence of further environmental cues to facilitate the investigation of the mechanisms which are still poorly understood. Here, we investigate whether the endocrine system of free‐ranging European blackbirds (Turdus merula) correlates with the amount of artificial light at night along a rural to urban gradient while the birds still encounter complementary environmental cues including seasonal variation in day length and temperature. Testosterone and estrone were assessed as metabolites in fecal samples and corticosterone in blood from mist‐netted blackbirds. We demonstrate that seasonal fluctuations in abiotic factors, individual conditions, but also light at night affect the reproductive and stress physiology of wild European blackbirds. Elevated artificial night light intensities were significantly positively correlated with corticosterone and negatively with female estrone levels. No effects of artificial light were found for testosterone levels. Our results suggest that female blackbirds in particular perceive even low levels of artificial light at night as a weak but chronic stressor that interacts with the hypothalamic‐pituitary‐gonadal axis and leads to a reduced secretion of reproductive hormones. These findings point out that the impacts of light pollution are diverse and we only slowly disentangle its multiple effects on physiology, ecology, and biodiversity.
Earlier breeding, lower success: does the spatial scale of climatic conditions matter in a migratory passerine bird?
Authors: Grimm Annegret , Weiß Brigitte M. , Kulik Lars , Mihoub Jean‐Baptiste , Mundry Roger , Köppen Ulrich , Brueckmann Tomas , Thomsen Ruth , Widdig Anja
Published: November 2015

Following over 20 years of research on the climatic effects on biodiversity we now have strong evidence that climate change affects phenology, fitness, and distribution ranges of different taxa, including birds. Bird phenology likely responds to changes in local weather. It is also affected by climatic year‐to‐year variations on larger scales. Although such scale‐related effects are common in ecology, most studies analyzing the effects of climate change were accomplished using climatic information on a single spatial scale. In this study, we aimed at determining the scale‐dependent sensitivity of breeding phenology and success to climate change in a migratory passerine bird, the barn swallow (Hirundo rustica). For both annual broods, we investigated effects of local weather (local scale) and the North Atlantic Oscillation (NAO, large scale) on the timing of breeding and breeding success. Consistent with previous studies in migratory birds we found that barn swallows in Eastern Germany bred progressively earlier. At the same time, they showed reduced breeding success over time in response to recent climatic changes. Responses to climatic variation were observed on both local and large climatic scales, but they differed with respect to the ecological process considered. Specifically, we found that the timing of breeding was primarily influenced by large‐scale NAO variations and to a lesser extent by local weather on the breeding grounds. Conversely, climatic conditions on the local scale affected breeding success, exclusively. The observed decrease in breeding success over years is likely a consequence of scale‐related mismatches between climatic conditions during different breeding phases. This provides further evidence that a species' response of earlier breeding may not be enough to cope with climate change. Our results emphasize the importance of considering the response of ecological processes along different climatic scales in order to better understand the complexity of climate change effects on biodiversity.
Relationships between vegetation type, peat hydraulic conductivity, and water table dynamics in mountain fens
Authors: Crockett Audrey C. , Ronayne Michael J. , Cooper David J.
Published: November 2015

The ecohydrologic function of fens is characterized by feedbacks between biological and hydrologic processes. Vegetation composition is one important factor that is both responsive to the site hydrologic regime and, by providing the organic material that determines peat hydrophysical properties, influences hydrologic conditions. In this study, we investigated the relationship between vegetation type and peat soil hydraulic conductivity in fen wetlands within the Rocky Mountain National Park, Colorado. We used ponded infiltration tests to estimate the saturated hydraulic conductivity of near‐surface peat in mountain fens with differing vegetation, including large‐sedge fens dominated by Carex aquatilis and Carex utriculata, small‐sedge fens dominated by Eleocharis quinqueflora, and fens with an abundance of woody plants and mosses. Estimated hydraulic conductivities were lowest at the fens dominated by E. quinqueflora, with a median value of 1·3 × 10−3 cm s−1 compared with 1·3 × 10−2 and 9·6 × 10−3 cm s−1, respectively, at the large‐sedge and woody fens. These data help explain historical water table observations at each fen. The E. quinqueflora‐dominated fens in our study area maintain a high water table with saturated conditions throughout the summer growing season. Other fens with higher‐conductivity peat show a more dynamic water table that is below ground surface by late summer. Copyright © 2015 John Wiley & Sons, Ltd.
Dysprosium‐ and Ytterbium‐Based Complexes Involving Tetrathiafulvalene Derivatives Functionalised with 2,2′‐Bipyridine or 2,6‐Di(pyrazol‐1‐yl)‐4‐pyridine
Authors: Feng Min , Speed Saskia , Pointillart Fabrice , Lefeuvre Bertrand , Le Guennic Boris , Golhen Stéphane , Cador Olivier , Ouahab Lahcène
Published: November 2015

Two new tetrathiafulvalene‐based ligands {L1 = 4,5‐bis[2,6‐di(pyrazol‐1‐yl)‐4‐pyridylmethylthio]‐4′,5′‐bis(methylthio)tetrathiafulvene, L3 = 4‐(4′‐methyl‐2,2′‐bypiridin‐4‐ylmethylthio)‐5‐(2‐cyanoethylthio)‐4′,5′‐ethylenedithiotetrathiafulvene} have been elaborated and four new lanthanide coordination complexes, namely [Dy2(hfac)6(L1)]·C6H14 (1; hfac– = 1,1,1,5,5,5‐hexafluoroacetylacetonate), [Ln(hfac)3(L2)]·CH2Cl2 {Ln = Dy (2) and Yb (3); L2 = 4,5‐bis[2,6‐di(pyrazol‐1‐yl)‐4‐pyridylmethylthio]‐4′,5′‐ethylenedithiotetrathiafulvene} and [Yb(hfac)3(L3)] (4) were isolated as single crystals. The lanthanide ions adopt an N3O6 nine‐coordination with either a spherical tricapped trigonal prism (D3h) or spherical capped square antiprism (C4v) as coordination polyhedra in complexes 1–3. In 4, the YbIII ion adopts an N2O6 eight‐coordination with a square antiprism (D4d) coordination sphere. The photophysical properties of the ligands L1 and L3 were studied in both solution and solid state and rationalised by time‐dependent density functional theory. Complex 2, in which the DyIII ion has the most regular C4v symmetry, behaves as a field‐induced single‐molecule magnet.
Environment friendly synthesis of magnetite–graphene composite for adsorption of toxic chromium (VI) ions from drinking water
Authors: Harijan Dilip K.L. , Chandra Vimlesh
Published: November 2015

Magnetite graphene composite (MGC) was synthesized via environment friendly route via thermal reduction of graphene oxide to graphene in alkali solution at 90°C and in the absence of toxic hydrazine hydrate. X‐ray diffraction pattern of MGC shows formation of magnetite phase with crystallite size of 10 nm. TEM image of MGC shows formation of regularly distributed magnetite particles on graphene sheets and average particle size of 10 nm. HRTEM image shows formation of lattice fringes with inter‐planar distance 0.482 nm. AFM shows formation of uniform size particles and cross sectional analysis shows formation of ∼10 nm magnetite particles and 2‐nm‐thick graphene sheets. The presence of different functional groups in the graphene oxide and MGC were confirmed from FTIR and Raman spectrophotometer. The sorption performance of MGC for Cr (VI) was evaluated. The maximum sorption capacity for Cr (VI) on MGC was 5.5 mg g−1 (pH =6.6) which was much higher than that of Fe3O4 nanoparticles. The graphene sheets could not only prevent agglomeration of the Fe3O4 nanoparticles and enable a good dispersion of this oxide, but also substantially enhance the specific surface area of the composite. The MGC composite may be a promising sorption material for the separation and preconcentration of heavy metal ions from aqueous solutions in environmental pollution cleanup. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 700–705, 2016
Context‐awareness over transient cloud in D2D networks: energy performance analysis and evaluation
Authors: Bisio Igor , Lavagetto Fabio , Sciarrone Andrea , Penner Terrence , Guirguis Mina
Published: November 2015

The exponential increase in the number and types of mobile devices, along with their ever‐growing sets of capabilities, have enabled the development of new architectures that aim to harness such heterogeneity. Transient clouds are examples of mobile clouds, which are created on‐the‐fly by the devices present in an environment to share their physical resources (e.g. CPU, memory and network) and would disappear as the nodes leave the network. They enable a device to go beyond its own physical limitations through utilising the capabilities offered by nearby devices over an ad hoc network. This idea exploits the device‐to‐device (D2D) communications paradigm, which allows two nearby devices to communicate with each other in the licenced cellular bandwidth without a base station involved.

In this paper, we present a transient context‐aware cloud (TCAC) paradigm based on the assumption that the nodes of the network care more about providing/learning higher level functionalities rather than lower level capabilities in D2D scenario. The proposed architecture, realised by using a WiFi Direct, can be portable through any paradigm, which exploits the D2D communications, so opening the doors to forthcoming 5G scenarios.

We present a prototype implementation of our architecture over Android smartphones connected via WiFi Direct along with the performance metrics (power/energy consumption and accuracy) to show the benefits of TCAC. A theoretical and analytical model for the energy consumption related to a device within the TCAC is provided as well. Copyright © 2015 John Wiley & Sons, Ltd.