bluuebunny/crossref_metadata_2025 huggingface dataset:
Antisense oligonucleotides (ASOs) and CRISPR systems are promising gene therapy treatments for Alzheimer's disease
Authors: Dowaidar Moataz
Published: June 2021

Animal models, together with the emergence of new technology, have considerably increased our understanding of the molecular processes implicated in Alzheimer's disease (AD) pathogenesis. These advancements have elucidated numerous critical A plaque development mechanisms, and it is quite some time until we can identify a viable cure for Alzheimer's disease. Animal models don't perfectly mimic the disease's intricacy. Another key challenge is the lack of molecular markers to detect early stages of the disease in the vast majority of patients. Precise and detailed diagnostic and therapeutic instruments are highly sought for. Dysregulation of AS may be present in up to 90% of all Alzheimer's cases. Using genetic polymorphisms such as sQTLs, which alter splicing processes involved in Alzheimer's disease, can help identify those who are at risk of the disease and may benefit from routine brain imaging to detect early stages of the disease.Human transcriptome and proteome complexity is impacted by AS. AS governs a distinct collection of genes than those regulated at the transcriptional level, and represents a second, adaptive layer of gene expression regulation. In fact, coordinated AS programs are important in embryonic development and extracellular signal response.The AD brain puts neurons and microglia under various stress. UPRER is triggered when one experiences dietary limitation, changes in redox potential, or if their calcium levels are too low. UPRER may both protect neurons and induce apoptosis in some instances. Furthermore, diabetes and mitochondrial dysfunction are rather prevalent, associated with elevated ROS formation (for a review on the connection between cellular stress and AD). Stress, along with the activation of the immune system, is known to have an effect on AS. The finding of stress patterns in the AD brain, which might help reduce AD risk through easy lifestyle alterations, may be attainable by transcriptome analysis.Research on the extensive inter-AS networks in AD must continue. The functional roles of several AS isoforms and their impact on AD are unknown; Splicing factors may be part of regulatory circuits that modulate the expression of other splicing factors, as previously reported; Patient-specific RBP aggregation afflicts a subset of AD patients, making identification of these patient-specific features difficult. Alzheimer's disease could be better understood and maybe new routes for the development of other neurodegenerative disorders could be discovered if characterizing splicing dysregulation is used.
Virus-like particles are good nanocarriers for liquid biopsy probes, imaging contrast agents, and anticancer medications
Authors: Dowaidar Moataz
Published: June 2021

Recent advances in nanotechnology, chemistry, and material science have spurred the development and deployment of virus-mimetic particles. Virus-like particles have several competitive advantages. Virus-like particles are good nanocarriers for liquid biopsy probes, imaging contrast agents, and anticancer medications because of these advantages. Despite these encouraging improvements, virus-mimetic particles still have a number of shortcomings, particularly in vivo immune response and tumor targeting efficiency. The immunogenicity of virus-like particles is reduced to some extent by PEGylation of the viral capsid surface, allowing for passive tumor targeting. PEGylation, on the other hand, causes the ABC phenomenon, which results in the formation of new immune responses. Researchers are currently looking for novel materials with immune camouflage properties to negate the immunostimulatory potential of particles. Although it is projected that altering some types of virus-like particles will increase their targeted internalization, the plasma proteins adsorbed by the particles will diminish particle-target cell affinity. The corona-mediated delivery technique improves in vivo targeting effectiveness and may pave the way for clinical translation of virus-mimetic particles. With quick knowledge renewal of nanoparticle in vivo behaviors and ongoing invention of research methodologies and procedures, virusmimetic nanoparticles are projected to be completely endowed with the twin roles of immune camouflage and tumor targeting, displaying great therapeutic effectiveness.
Hospitalitas Kristen
Authors: Meldayantymelda@gmail.com
Published: June 2021

Abstrak: hospitalitas Pelayanan merupakan suatu kegiatan atau urutan kegiatan yang terjadi dalam interaksi langsung antara seseorang dengan orang lain, tetapi pelayanan bukan hanya melakukan pelayanan di gereja atau pemberitaan Firman Tuhan tetapi dimana kita dapat membantu orang lain yang membutuhkan bantuan kita. Dengan melakukan pelayanan harus dilakukan dengan iklas dan sepenuh hati serta ramah tamah kepada mereka supaya itu juga menjadi berkat bagi kita yang malakukan pelayanan tersebut. Diakonia dapat berarti melayani. Ketika mendengarkan kata melayani atau pelayanan bagi orang Kristen tidaklah sulit. Tetapi perluh juga dikatahui bahwa berdiakonia tidak semudah hanya diucapkan dengan kata-kata. Pelayanan diakonia, perwujudan kasih yang berbentuk pelayanan sosial yang missioner, yaitu tindakan nayat orang Kristen yang peduli terhadap persoalan dunia dan masyarakat. Tindakan Allah dalam turut serta memilihara, melindungi, dan menyalamatkan dunia ini bagi manusia dan seluruh alam semesta.
Development and Application of Novel Performance Validity Metrics for Computerized Neurocognitive Batteries
Authors: Scott J. Cobb , Moore Tyler Maxwell , Roalf David R , Satterthwaite Theodore D. , Wolf Daniel H. , Port Allison M. , Butler Ellyn , Ruparel Kosha , Nievergelt Caroline M. , Risbrough Victoria B. , Baker Dewleen G. , Gur Raquel E. , Gur Ruben C.
Published: June 2021

Objective: Data from neurocognitive assessments may not be accurate in the context of factors impacting validity, such as disengagement, unmotivated responding, or intentional underperformance. Performance validity tests (PVTs) were developed to address these phenomena and assess underperformance on neurocognitive tests. However, PVTs can be burdensome, rely on cutoff scores that reduce information, do not examine potential variations in task engagement across a battery, and are typically not well-suited to acquisition of large cognitive datasets. Here we describe the development of novel performance validity measures that could address some of these limitations by leveraging psychometric modeling from data embedded within the Penn Computerized Neurocognitive Battery (PennCNB). Method: We first developed these validity measures using simulations of invalid response patterns with parameters drawn from real data. Next, we examined their application in two large, independent samples: 1) children and adolescents from the Philadelphia Neurodevelopmental Cohort (n=9,498); and 2) adult servicemembers from the Marine Resiliency Study-II (n=1,444). Results: Our performance validity metrics detected patterns of invalid responding in simulated data, even at subtle levels. Furthermore, a combination of these metrics significantly predicted previously established validity rules for these tests in both developmental and adult datasets. Moreover, most clinical diagnostic groups did not show reduced validity estimates. Conclusion: These results provide proof-of-concept evidence for multivariate, data-driven performance validity metrics. These metrics offer a novel method for determining the performance validity for individual neurocognitive tests that is scalable, applicable across different tests, less burdensome, and dimensional. However, more research is needed into their application.
Adults' Health-Related Problem Solving Is Facilitated by Number Lines, But Not Risk Ladders and Icon Arrays
Authors: Mielicki Marta , Fitzsimmons Charles , Schiller Lauren , Scheibe Daniel Aaron , Taber Jennifer M , Sidney Pooja , Matthews Percival G , Waters Erika A. , Coifman Karin , Thompson Clarissa A.
Published: June 2021

Visual displays, such as icon arrays and risk ladders, are often used to communicate numerical health information. Number lines improve reasoning with rational numbers but are seldom used in health contexts. College students compared rates for information related to COVID-19 (e.g., number of deaths and number of cases) in one of four randomly-assigned conditions: icon arrays, risk ladders, number lines, or no accompanying visual display. As predicted, number lines facilitated performance on these problems – the number line condition outperformed the other visual display conditions, which did not perform any better than the no visual display condition. In addition, higher performance on the health-related math problems was associated with higher COVID-19 worry for oneself and others, higher perceptions of COVID-19 severity, and higher endorsement of intentions to engage in preventive health behaviors, even when controlling for baseline math skills. These findings have important implications for effectively presenting health statistics.
Managing clients and patients: Exploring the experience of client-based incivility in veterinary practice
Authors: Irwin Amy , Hall Dionne , Ellis Hannah
Published: June 2021

Background: Interactions with clients have been identified as a key potential stressor within veterinarian work. However, there is a lack of research investigating the experience, and impact, of specific behaviours such as incivility. The current study aimed to address this literature gap by investigating veterinary perceptions of client-based rudeness. Method: Telephone interviews were used to gather qualitative data regarding veterinary perceptions of client-based rudeness. This encompassed the potential causes of incivility, the impact on the veterinarian, and coping strategies.Results: Thematic analysis produced 16 themes relevant to client-based rudeness, and one over-arching theme. The over-arching theme suggested that vets consider client management, and patient care, two distinct aspects of their role. Key themes included the perception of client worry as a key causal factor of rudeness, the utilisation of empathy as a client management technique and the potential for rudeness to have an adverse impact on mental health. A supportive practice was considered vital for enabling successful coping.Conclusion: It is important that veterinary practices are aware of the potential for client rudeness to adversely impact vet wellbeing. Practices should seek to develop guidelines detailing appropriate responses to rudeness, alongside developing a supportive culture to maximise vet coping strategies.
On the heterogeneity of preferences for disability services
Authors: Randle Melanie , Grün Bettina , Dolnicar Sara
Published: June 2021

This paper investigates heterogeneity of preferences for disability services within the theoretical framework of consumption values. We conducted interviews with people with a disability and disability service providers to develop survey items, then conducted a survey with 2000 adult Australian residents who either had a disability or were carers of a person with a disability. After conducting descriptive analyses and data-driven market segmentation, findings revealed that, at the aggregate level, basic or functional benefits of disability services are most important. However, when accounting for heterogeneity, very distinct benefit patterns emerge, pointing to the substantial potential for improving disability services by catering to distinct market segment needs. These insights have the potential to improve disability service provision, thus maximally harvesting the opportunities from disability service models that now often include commercial providers, and enabling people with disabilities to make optimal choices in relation to both services and providers.
Understanding and interpreting the effects of prior cognitive exertion on self-regulation of sport and exercise performance
Authors: Graham Jeffrey D , Brown Denver M. Y.
Published: June 2021

Over the past decade there has been considerable research into the effects of prior cognitive exertion on subsequent self-regulation of sport and exercise performance. In this chapter we provide an overview of how this body of literature has developed amongst two parallel, yet separate perspectives - self-control and mental fatigue – and where it currently stands. The prominent theories in the field are discussed and areas that warrant further investigation moving forward are highlighted. This includes discussion of factors known to mediate and moderate this relationship, and future directions that will help us elucidate underlying mechanisms.
"SILK ROAD" AND CHINESE DIRECT INVESTMENT IN HIGH-TECH INDUSTRIES OF THE EU
Authors: Senyuk Ninel , Terukov Ivan
Published: June 2021

This article presents a study of the dynamics of the distribution of Chinese direct investment in high-tech industries within the EU. The influence of Chinese FDI on the EU regulatory policy and the specifics of bilateral relations between the PRC and the EU member states in the field of high technologies were also studied. Based on data from the China Global Investment Tracker, the article analyzes the dynamics of Chinese investment flows to the EU from 2005 to 2019 and the distribution of Chinese investments by the EU member states and sectors of national economies before and after the implementation of China’s Belt and Road global initiative. Using a structured semi-formalized online survey of employees of high-tech companies located in the EU, the paper describes the specifics of cooperation with Chinese investors, the personal attitude of survey participants to the growth of Chinese investment capital in the EU and the respondents’ opinion on the prospects for the development of investment relations between the EU and the PRC. Based on the results of the empirical analysis, the following conclusions were drawn: China seeks to increase the export of capital to the EU, especially in the high-tech and infrastructure sectors. The EU’s strategic response is to develop common regulatory rules. However, the countries of Central and Eastern Europe are interested in increasing Chinese investment inflows much more than their western neighbors, and this fact increases the spread of opinions within the integration union. In addition, the implementation of the Belt and Road program has strengthened the positions of such southern European states as Italy, Greece, Portugal, as global information technology and infrastructure hubs within the framework of China-EU investment relations. At the same time, the consequences of Brexit, the global pandemic and the growth of protectionist sentiments of the EU leadership towards Chinese FDI will certainly have a negative impact on the volume of investment flows from China to the EU in the short term.
BALKAN VECTOR OF BELARUS FOREIGN POLICY (LATE XX - EARLY XXI CENTURIES)
Authors:   INION RAN, Shanshieva Larisa
Published: June 2021

The article examines the Balkan vector of the Belarus’ foreign policy in the context of the concept of a multi-vector policy. It is noted that the Republic of Belarus (RB), created as an independent state after the collapse of the Soviet Union in 1991, initially attached great importance to the establishment of mutually beneficial relations with different countries. This approach laid the foundation for the subsequent formation of the named concept. The thesis is expressed that the implementation of a multi-vector policy entailed certain contradictions. They were based on the need to constantly maintain a balance in relations between the Republic of Belarus and countries that have different economic and political systems and are members of various regional associations. On the one hand, Belarus has established strong allied relations with Russia and joined organizations such as the EAEU and the CSTO. On the other hand, it actively established trade and economic relations with the countries of the European Union, as well as with China and the United States. The main attention is paid to the Balkan vector of international cooperation of the Republic of Belarus, first of all to the Belarusian-Serbian relations. It is noted that the Belarusian leadership sought to cooperate with other Balkan countries, involving them in the orbit of trade and economic ties in the EAEU markets. The main research methods are the content analysis method and the predictive method. The author analyzes the features of the modern political situation in Belarus, caused by the ambiguous results of the presidential elections on August 9, 2020. It is concluded that the confrontation between the authorities and society will have negative consequences for the foreign policy of the Republic of Belarus, for its relations with other states, including the Balkans.
WARMING IN THE ARCTIC: OPPORTUNITIES AND RISKS
Authors:   INION RAN, Zhilina Irina
Published: June 2021

The dynamics and forecasts of climate change in the Arctic as a result of global warming on the planet are considered. The article analyzes the influence of climate change on the natural environment, some sectors of the economy and social sphere of the Arctic zone of Russia, and the way of life of the indigenous peoples of the North.
ВОЗДЕЙСТВИЕ СРЕДСТВ МАССОВОЙ ИНФОРМАЦИИ КАЗАХСТАНА НА ЭТНОПОЛИТИКУ РЕСПУБЛИКИ (АНАЛИТИЧЕСКИЙ ОБЗОР)
Authors:   INION RAN, Schensnovish Valentina
Published: June 2021

На нынешнем этапе актуальна тема влияния СМИ на этнополитику. Исследователи показывают: многонациональному государству, каким является Казахстан, приходится учитывать, что СМИ сегодня часто становятся главным источником информации для населения. Иначе деструктивные оппозиционные силы, обостряя существующие межнациональные конфликты, могут привести к распаду государства.
REISLAMIZATION OF MUSLIM LIFE IN CENTRAL ASIA AT THE END OF THE 20TH CENTURY
Authors: Ikromov Shavkat
Published: June 2021

The author describes changes in the religious life of Muslims of the former Soviet republics that took place during the period 1989-91. At this particular time a delegation of representatives of the Organization of the Islamic Conference headed by Sheikh Muhammad Nasir Al-Abudi visited the republic. The text was prepared on the basis of the sheikh's diary entries, which were subsequently published in Arabic and aroused great interest in Muslim countries.
BETWEEN JEKYLL AND HYDE: DIGITAL ALTER EGO IN THE CONTEXT OF PERSONALITY COGNITIVE DEVELOPMENT
Authors: Akhmetova L.V. , Shkaev Dmitriy
Published: June 2021

In the article the authors address one of the key aspects of the new reality - the digital personality - emerging in the environment of computer games and social networks. From the authors' point of view the digital alter ego not only marks the beginning of a new era in interdisciplinary research but also defines the essence of deviant behavior that user can broadcast from online mode to the real world.
ACTUAL ETHICAL PROBLEMS OF MODERN SCIENCE
Authors:   INION RAN, Letov Oleg
Published: June 2021

This review examines moral and legal issues such as the movement of self-driving cars, human-machine cooperation in the field of health and others. It is noted that patients receiving palliative care may have an increase in life expectancy. The exercise of their right to choose will also become more and more real, given that competence is a complex concept where rationality is integrated with emotional understanding and human intuition.
BOOK REVIEW: MARKOVIć L. NIJE DOBRO ALI IMA NáDE. EUROPA I NJEZINE DILEME. [MARKOVIC L. NO THAT IT’S GOOD, BUT THERE’S HOPE. EUROPE AND ITS DILEMMAS]
Authors:   INION RAN, Kaloeva Elena
Published: June 2021

This paper is a review of the book written by the famous Croatian-German researcher L. Markovic, containing answers primarily to such challenges facing Europe as the migration crisis, the confrontation of Christianity and Islam, abd the upsurge of right-wing radicalism. The author makes an attempt to help «a little» man overcome his fears associated with finding a rightful place in the modern world.
BYZANTINE SYMPHONY AND AUTOCRACY: DIALECTICS OF THE CIVILIZATIONAL MIND
Authors:   INION RAN, Skvortsov Lev
Published: June 2021

The influence of the Byzantine Symphony on state policy in Russia is considered. It is noted that the interaction of the Patriarch and the Tsar was aimed at influencing Christian morality to mitigate the power aspect of the autocracy's policy and the influence of the Tsar on the behavior of his entourage. The author analyzes the historical contradictions of this process that emerged during the reign of Ivan the terrible and Peter the Great, and the reasons for the abolition of the Patriarchate, and the consequences of the concentration of state and spiritual power in the hands of the autocrat. The factors influencing the reanimation of the philosophy and logic of the Byzantine Symphony in its transformed form - in relation to modern conditions-are considered.
Optimasi Dosis Koagulan Untuk Pengolahan Air Sungai Suko
Authors: Aini Syarifah
Published: June 2021

Sungai Suko, desa drono, kecamatan Ngawen, kabupaten Klaten, terletak di dekat jalan raya, pemukiman penduduk dan pabrik tahu, kemungkinan air mengalami pencemaran cukup tinggi, yang disebabkan oleh limbah rumah tangga, baik limbah organik maupun limbah anorganik. Air sungai ini dapat diolah menjadi air bersih dengan proses koagulasi dengan metode Jar Test  menggunakan koagulan tawas, PAC dan kaporit. Tujuan dari penelitian adalah untuk mengetahui dosis optimum koagulan dalam pengolahan air sungai Suko menjadi air bersih dengan metode Jart test dan mengetahui koagulan mana yang paling cocok digunakan dalam mengolah air sungai Suko menjadi air bersih. Metode penelitian ini adalah menggunakan percobaan Jar Test untuk menentukan dosis koagulan optimum dalam mengolah air sungai Suko menjadi air bersih, sampel air sebelum percobaan diuji kualitasnya terlebih dahulu, kemudian hasil percobaan akan diketahui tingkat kejernihan airnya. Hasil penelitian menunjukkan kadar tawas optimum percobaan adalah 120 ppm yaitu dengan menambahkan 6 ml tawas ke dalam 500 ml air, kadar PAC optimum percobaan adalah 200 ppm yaitu dengan menambahkan 10 ml PAC ke dalam 500 ml air, kadar kaporit optimum percobaan adalah 160 ppm yaitu dengan menambahkan 8 ml kaporit ke dalam 500 ml air.
Manejo do ácaro rajado (Tetranychus urticae Koch) em cultivos de gérbera:controle biológico com ácaros predadores (Phytoseiidae), influência de cultivares e agroquímicos
Authors:   , Macena Angelita Berto de
Published: June 2021

A gérbera (Gerbera jamesonii Adlam) está entre as ornamentais mais cultivadas e se destaca por ter uma grande variedade de cores e por sua alta durabilidade.A cultura vem sofrendo sérias injúrias devido ao ataque do ácaro rajado, Tetranychus urticae Koch (Acari: Tetranychidae) que afeta a produção e a qualidade das flores. Um dos problemas associados ao controle químico da praga é a seleção de populações resistentes aos principais acaricidas registrados no Brasil. Assim, o uso de inimigos naturais tem sido um dos controles mais viáveis e eficientes para o controle desta praga. Ácaros predadores da família Phytoseiidae, com destaque para as espécies Neoseiulus californicus (McGregor) e Phytoseiulus macropilis (Banks), vêm sendo utilizados por produtores de ornamentais no Brasil, com resultados promissores para o combate de ácaro rajado. O objetivo do trabalho foi avaliar a influência de diferentes cultivares de gérbera sobre a infestação de ácaro rajado, assim como o efeito de liberações de ácaros predadores (P.macropilis e N. californicus) para o controle de T. urticae nas diversas cultivares de gérbera, no município de Holambra, SP.
Caracterização da população de Phytophthora infestans (Mont) de Bary em regiões produtoras de batata (Solanum tuberosum L.) no Brasil
Authors:   , Zanotta Samantha
Published: June 2021

A requeima, causada por Phytophthora infestans (Oomycota, Stramenopila), é uma das doenças mais destrutivas na bataticultura mundial, podendo comprometer a produção em poucos dias. Este trabalho tem como principal objetivo a caracterização da população de Phytophthora infestans nas regiões produtoras de batata no Brasil e, para isso, teve como objetivos específicos: i) obter isolados de P. infestans a partir de plantas de batata com sintomas de requeima oriundas de diferentes regiões produtoras do país; ii)iIdentificar e monitorar o tipo de reprodução de isolados de P. infestans existentes no Brasil; iii) caracterizar os isolados do patógeno quanto ao grupo de compatibilidade; iv) caracterizar os isolados do patógeno quanto ao genótipo empregando-se marcadores moleculares tipo SSR; v) avaliar a sensibilidade dos genótipos de P. infestans a quatro ingredientes ativos com diferentes mecanismos de ação, utilizados para o controle químico do patógeno. Para isso, material botânico (folhas, hastes, caules, frutos e tubérculos) manifestando sintomatologia típica de requeima, provenientes de diversos locais produtores de batata pelo Brasil, foi coletado. Destas coletas foram realizadas as análises quanto ao tipo de reprodução presente e o isolamento do patógeno para estudo da população de P. infestans.
Anatomic Veterinary Usage: Discussion Around Technical Nomenclature Vs. Jargon
Authors: Parés-Casanova P.M.
Published: June 2021

This article discusses some examples of problems derived from the mix of technical jargon and anatomical veterinary words and makes recommendations regarding their use according to specific situations.
BUILDING ORGANIZATIONAL SYSTEM FRAMEWORK MODEL FOR CRISIS MANAGEMENT AND SUSTAINABILITY IN CONSTRUCTION SECTOR OF GEORGIA
Authors: Ana Tvaliashvili  , Ketevan Chiabrishvili
Published: June 2021

The breakout of COVID-19 pandemic is followed by the unexpected and continuous crisis in all fields of activities. Literature is describing the features of challenges of different levels in different segments of economic performance. Georgia’s economic development is experiencing inevitable changes, which are not necessarily negative. Crises often lead to changes in the entrepreneurial mindset. The companies start considering new business models for future continuous operations and long-term sustainability. We set studying the current anti-crisis strategies of the construction companies and development of recommended system framework as a research problem. There was considerable doubt whether companies had strategy and plan for handling the crisis beforehand. The article provides some research findings on how companies managed to bring uncertainties and losses to a minimum. The method of interview allowed conducting qualitative analysis of different factors impacting construction projects. The pre-crisis performance, challenges during the crisis, and signs of recovery period are characterized. Study highlights the role of government in maintaining business operations. The results of survey and model for improved resilience is developed and introduced representing recommended set of resources, components of business process for desired outputs and outcomes in the construction business in Georgia.
The growth, development and meat qualities characteristics of different genotypes lambs
Authors:   Institute of Steppe Animal Husbandry named after MF Ivanova ", Iovenko V. ,   Askania-Nova",   - National Scientific Breeding and Genetics Center for Sheep Breeding, Hladii I. ,   Institute of Steppe Animal Husbandry named after MF Ivanova "Askania-Nova" - National Scientific Breeding and Genetics Center for Sheep Breeding.
Published: June 2021

The growth, development and meat qualities characteristics of different genotypes lambs he growth and development features of three different genotypes ram-lambs, from their birth to six months age, were studied, in particular: purebred youngling of the Ascanian Fine-Fleeced breed (AFF), a cross of this gene pool with the Texel (AFFxT) and Merinolandschaf (AFFxM) breeds. Control over the growth and development these experimental animals was carried out by weighing in different age periods. The meat quality was assessed based on the slaughter results. It was found that the best development parameters were characteristic for the Texel crossbred with the Ascanian Fine-Fleeced breed; therefore, this crossing option has the meat productivity highest genetic potential. Keywords: sheep, genotype, live weight, linear parameters, growth rate.
Володимир Менчиць (1837–1916) на тлі епохи
Authors: Романюк Неля , Сініцький Андрій
Published: June 2021

Purpose of the article is to broaden the knowledge about the Ukrainian national movement, problems of the creation of a nation in 19th – beginning of the 20th century through the prism of life and activities of an individual person – Volodymyr Amvrosiiovych Menchyts, as a cultural and educational figure. The methodology of research is based on a combination of general scientific and special historical methods with the principles of historicism, objectivity and consistency. The application of these methods made it possible to conduct a systematic analysis of the sources that helped to personify the figure of V. Menchyts. Scientific novelty. The role of V. Menchyts against the backdrop of the epoch of the second half of the 19th – early 20th century has been highlighted on the basis of published and archival documents. His role was marked by the intensification of the national movement, the formation of the idea of state formation of Ukraine. Conclusions. Research into the biography of Volodymyr Amvrosiyovych Menchyts and its reproduction showed that he was an outstanding personality, a bright representative of the Ukrainian national movement of the second half of the 19th – beginning 20th century. He entered Ukrainian history as an educator and philosopher, a collector of Ukrainian folklore, and a specialist in literature and publishing. V. Menchyts was a representative of the spiritual elite of the society of that time. Those people contributed to the formation of moral and ethical foundations of the social worldview, national idea and state formation of Ukraine. A significant constellation of figures that developed and acted in this period in society, in particular Volodymyr Menchyts and his company, clearly defined the outlines of the Ukrainophil movement. Along with a cohort of less known but, undoubtedly, sincere patriots, the famous representatives of this movement were able to lay the ideological foundation for the development of the Ukrainian state at the beginning of 20th century.
Емблематика пострадянської Донеччини: офіціоз «господарників», переробки «з народу», альтернативи апологетів «русского мира»
Authors: Мєлєкєсцев Кирило
Published: June 2021

The purpose of the article is the analysis of the development of Donetsk region emblems (official heraldry and vexillology of Donetsk Oblast, reflection of historical themes in commercial nomenclature, reinterpretations of official symbols by individuals) in 1991–2015, identifying the main trends in the development of emblems, their connections with the views of customers and authors on history and politics, transformations of symbolics. The methodology of the research is based on the principles of historicism, objectivity, and systematics. General scientific and special-historical methods were used, such as content analysis, generalization, chronological, retrospective methods. The scientific novelty is based on it being the first attempt to generalize various elements of emblem studies of the Donetsk region, for the first time going beyond the official heraldry and vexillology of the Oblast, while considering their transformation in the hands of non-state actors. Conclusions. The post-Soviet era emblems of Donetsk and the Donetsk Oblast were developed in a unique situation: on the one hand local elites wanted to move away from Soviet symbols and modernize Donetsk as a “brand”, and on the other hand, due to the peculiarities of these elites’ education, origins and political preferences, did not perceive the region’s history. outside of the Soviet stereotypes about “Donbas as the economic center.” As a result, local elites ignored Cossack history of the Donetsk region in contrast to the perpetuation of industrial achievements of the Russian Empire (such as the Oblast’s coat of arms motto with a quote from Dmitri Mendeleev, “The Mertsalov Palm Tree”, as well as various “John Hughes/Yuz” nomenclature). Over the decades, there has been a divergence of traditions of Donetsk emblem use: official, business, and national-patriotic. At the same time, pro-Moscow organizations have been developing and imposing a separate emblem tradition since 1991, based on historical myths around the Donetsk-Kryvyi Rih Soviet Republic, but detached from both the old Soviet symbols and the new official Donetsk emblems. The latter were developed to symbolize the “uniqueness” of eastern Ukraine, the “separateness” of Donetsk region, but did not actually intersperse with Russian symbols (with the exception of the Russian-language motto). In this form, it did not meet the goals of Moscow’s agents of influence, but was accepted and reworked by pro-Ukrainian patriotic forces. Thus, the use of one or the other version of Donetsk region symbols indicates a person’s political beliefs, their understanding of regional history and “memory politics” around it.
Ревізія ігуменів монастирів Львівської унійної єпархії 1724 р.
Authors: Павлишин Андрій
Published: June 2021

The aim of the research is to introduce an important source of the history of the church, in particular the monasticism of the Lviv Union eparchy of the first half of the XVIII century into scientific circulation – “Inspection of the hegumens of the Lviv eparchy in 1724”. The methodology of the researchis based on the principles of historicism, analytical and synthetic critique of sources. Comparative and typological general historical methods are also used.The scientific noveltyis in the introduction of the source, which most fully reflects the real state of monasticism of the Lviv eparchy in the first quarter of the XVIII century into wide circulation for the first time. Conclusions: As a result of archival searches, a historical source “Inspection of the hegumens of Lviv eparchyin 1724”was discovered and put into scientific circulation. It is the first complete description of the existing monasteries of the Lviv dioceseand allows to recreate their detailed network at the first quarter of the XVIII century. For the first time, the document also reliably outlines the number of monastic communities in the eparchy. Onthebasisofinspection it can be stated that the Lviv Union diocesein 1724 had 62 monasteries with 341 monks. The source also allows us to trace the power of bishops over monasteries, in particular the mechanism of hegumens subordination to bishops. The document contains valuable information about the relationship of monasteries, in particular the subordination of smaller monastic communities to larger ones. No less important are the sources about the economic situation of the monasteries.In 1724, only 34 out of 62 monasteries, showed documents for the right to own some land plots, which allows us to speak of a relatively modest monastic farming. “Inspection of the hegumens of the Lviv eparchy in 1724”, is a key source that allows us to characterize not only the state of monasteries, but also the Lviv eparchy in general in the first decades after the adoption of the Brest Union by the diocese.
Long Working Hours, Stress, Turnover and Organization Commitment among Employees in Banking Sector
Authors: Khan Faisal , Nisar Suneeza , Malik Muhammad Faizan
Published: June 2021

The main aim of the study is to examine the impact of a long working hour on stress, turnover and commitment of employees in the baking sector District Swabi. Stress affects the state of equilibrium. Stress is the reaction on the employees when there are a lot of pressures on them it can be workload, office environment or other factors. The data were collected through self-administrated from 234 respondents of the banking sector. The findings of the study show that there is a positive relationship between long working hours with turnover and stress while a negative relationship with organizational commitment. For enhancing both organizational and employee's productivity, the administration and policymakers need to increase compensations, organizational commitment and rewards. This study also provides the limitations and recommendations for further research.
China in Quesnay’s doctrine: Interpretations, translations, cultural aspects
Authors:   Institute of Far Eastern Studies, Russian Academy of Sciences, Moscow, Russia, Borokh O.N.
Published: June 2021

The paper analyzes the Chinese influences on the doctrine of the French physiocrat François Quesnay from the perspective of the cultural specifics of the perception of economic and political ideas. The approaches of Chinese researchers were impacted by Marxist methodology, sinocentric views and fragmentary use of primary sources. The application of the Marxist concept of socio-economic formations supported the arguments that feudal Confucianism could not influence the views of physiocrats, which reflected the emergence of capitalist relations. In the 18th century opponents of the physiocrats used the comparison of the Tableau Économique with the scheme of the Chinese Book of Changes to disqualify Quesnay’s doctrine. For Chinese researchers this comparison became a confirmation of the value of the Tableau Économique and an incentive to search for the ideas of circular flows and equilibrium in both tables. The study of Despotism in China content confirms its connection with the actual historical China. It is concluded that Chinese scholars seek to interpret the historical precedent of the influence of Confucian thought on Quesnay’s doctrine in the context of plans to increase the global clout of China’s social sciences.
PENERAPAN PEMBELAJARAN BACA TULIS AL-QUR’AN DENGAN MENGGUNAKAN METODE AL-HUSNA DI SD NEGERI CANDIREJO
Authors: Nugroho Bekti Taufiq Ari , Mustaidah Mustaidah
Published: June 2021

Jenis penelitian ini adalah kualitatif deskriptif, yaitu penelitiankualitatif yang berusaha menggambarkan dan menginterpretasi objek sesuai dengan apa adanya. Metode ini digunakan untuk menganalisis data mengenai obyek penelitian yaitu SD Negeri Candirejo, serta untuk menyimpulkan data-data di lapangan yang berhubungan dengan pelaksanaan metode Al-Husna dalam pembelajaran membaca Al-Qur`an.

Hasil penelitiannya adalah Penerapan metode Al-Husna di SD Negeri Candirejo, mempunyai ciri khas tersendiri yaitu dengan pendekatan Klasikal dan Individual. Pendekatan metode Al-Husna dilaksanakan dengan 3 tehnik yaitu: 1) Tehnik 1 (tartil yaitu Tartil ialah mentajwidi huruf dan mengenal dimana harus waqaf); 2) Tehnik 2 (guru membaca siswa menirukan); 3) Tehnik 3 guru dan siswa sama-sama membaca dengan kaidah rasm utsmani. Evaluasi dalam tilawati ini dilakukan setiap 3 bulan sekali untuk kenaikan jilid. Sedangkan untuk kenaikan halaman setiap di akhir pertemuan sebelim pulang, dengan ketentuan dari pendidik, dan sesuai pedoman pelaksanaan imtihan.
Collaborative robotics: a literature overview from the perspective of production management
Authors: Sordan Juliano Endrigo , Pimenta Marcio Lopes , Oprime Pedro Carlos , Rodrigues Yasmine Tomasella , Marinho Clesio Aparecido
Published: June 2021

Purpose: This paper aims to understand the specificities inherent to collaborative robotics from the perspective of production and operations management, as well as to identify opportunities for future research on the topic.
Methodology/Approach: A systematic literature review was carried out through Scopus and Web of Science databases. This procedure covered 84 articles published between 1997 and 2018.
Findings: The study revealed the issues most addressed in the research on Collaborative robots (Cobots), the most cited works, and the research approaches adopted.
Research Limitation/implication: The sample was extracted from only two international databases excluding publications in the form of books and articles from other databases.
Originality/Value of paper: The study reveals some specificities regarding the application and development of COBOTs, as well as their advantages and drawbacks in the scope of production management.
Première mention en France et en Italie du Lépidoptère alticole Dahlica wehrlii (Müller-Rütz, 1920) dans le massif du Mont-Blanc (Lepidoptera, Psychidae)
Authors: Leraut Guillaume
Published: June 2021

First record in France and Italy of the high-altitude-living moth Dahlica wehrlii (Müller-Rütz, 1920) in the Mont-Blanc massif (Lepidoptera, Psychidae). The Lepidoptera Psychidae Dahlica wehrlii (Müller-Rütz, 1920), a species inhabiting high-altitude biotopes and up to now recorded only from Switzerland, is mentioned from the Mont-Blanc massif, both in France and in Italy. Observation conditions as well as biological elements are given.
The genus Orthochirus Karsch, 1891, in Algeria with description of a new species (Scorpiones, Buthidae)
Authors: Lourenço Wilson R. , Sadine Salah Eddine
Published: June 2021

A new species of Orthochirus Karsch, 1891 (Scorpiones, Buthidae) is described from El-Oued, Debila, in Algeria. The number of confirmed Orthochirus species from Algeria is now raised to two. Further studies most certainly will clarify the status of yet undescribed populations.
AUDITORY REACTION TIME MEASUREMENT WITH OBSERVER-BASED PSYCHOPHYSICAL PROCEDURE
Authors: Baskurt Yasam Yildirim , Kirkim Gunay
Published: June 2021

Reaction is defined as a behavioral response to a stimulus. The stimulus can be auditory or visual. Reaction time (RT) is determined as the time between the onset of the stimulus and response. According to this definition, the auditory RT is the time between the auditory stimulus and the response. Simple reaction time has been the subject of comparison of many different groups with both auditory and visual stimuli. When the simple auditory and visual RT in normal hearing individuals are compared, it has been observed that the auditory RT is faster than visual reaction. Auditory RT in womens's was observed slower than men. In many different studies, average values are 180-200 ms for visual RT and 140-160 ms for auditory RT with normal hearing and sighted individuals.
Keywords: Reaction Time, Cochlear Implant, Hearing loss
SOCIAL PHOBIA (SOCIAL ANXIETY DISORDER) DURING COVID-19 IN MEDICAL INTERNSHIP STUDENTS
Authors: Dixit Nidhi , Choubey Vishal , Desai Samir N
Published: June 2021

Background & Method: A cross sectional study was conducted on 100 internship students (50 male and 50 female students). To assess Social Phobia (Social Anxiety Disorder) during COVID-19 Pandemic in medical internship students based on determination of frequency, quantifying the symptoms, severity & socio demographic profile, duration of study – conducted from May to July 2020.

Result: In our study we found, social phobia present in 44% in males & 38% in females. ?2 = 7.714, p = 0.05, Highly significant.

Conclusion: According to my study, frequency of Social Phobia is 82% during COVID-19 in medical internship students. Our study suggests that during COVID-19, mild and moderate degree of social phobia is maximum in medical interns of both sexes. Proper psycho education along with sessions of applied relaxation and social skills training was given to medical internship students because of their high prevalence of social anxiety disorder during COVID-19 which was quite successful.

Keywords: social phobia, clinical, anxiety & disorder.
The Definition of Specific-Purpose English Language Competences Needed in Border Control and Their Development Potentials
Authors: Borszéki Judit
Published: June 2021

The aim of this series of papers is to present modern methods of linguistics and language pedagogy concerning specific-purpose language competences and to describe the English competences EU border guards need for their work and international activities and to explore the prospects for their improvement. The first part discusses the dilemmas and methodology related to the definition of specific-purpose language competences, indispensable for language course design. The second and the third parts wish to prove that the ongoing FRONTEX project entitled English Communication for Border and Coast Guards very well illustrates how the new approach to needs analysis methods is used to define the English language skills needed for border control in the EU. Using the authentic material provided by border guards and the Common European Framework of Reference for Languages, the author also makes an attempt to define the ESP competences at various levels, needed for their work, according to the categories used in applied linguistics. The second and the third parts discuss elementary and intermediate (A2/B1) and upper-intermediate (B2) EBG competences respectively.
Koronavírus a szabálysértés szemszögéből
Authors: Skorka Tamás
Published: June 2021

A koronavírus az élet minden területén éreztette hatását, így a változások a szabálysértési jogterületet is elérték. Az új helyzet új megoldásokat kívánt, a lehető leggyorsabban, így a vírus leküzdése elleni szabályok kormányrendeletek sorában láttak napvilágot, amelyek betartatását a szabálysértési jog szankciórendszere biztosította.
Innovative profile of the Russian pharmaceutical industry
Authors: Podshivalova M. V. , Pylaeva I S. , Almrshed S. K.
Published: June 2021

InnoThe article examines the specifics of innovative activity of Russian drug manufacturers, which in the context of a COVID-19 pandemic become a matter of national security. The research is based on panel data: out of a total of 1,816 enterprises in the industry, a sample of 345 innovatively active enterprises is formed with a time series of data 20 years long. The sample is diversified by the scale of enterprise activity into 4 groups: micro enterprises, small, medium, and large enterprises. These types of enterprises are compared both in absolute terms — size of investments in intangible assets, age, and in relative ones — frequency of investments in innovations, coefficient of autonomy, profitability of sales and assets, share of intangible assets in revenue and assets. The analysis was supplemented by enterprises not included in the sample to identify the effectiveness of innovation in the industry. The result is the innovative profile of industrial enterprises in the context of the scale of their activities. The conclusion is drawn about the specifics of the domestic pharmaceutical industry innovation activity, which generally coincides with the established distribution of roles in the global pharmaceutical industry, when large enterprises are leaders in the innovations development and implementation. Russian large companies also tend to use micro enterprises to implement risky projects. The authors conclude that in Russia, the foundations have been formed for transition to a new model of pharmaceutical industry innovative development. This model is based on cooperation of small and large businesses.
The transparency of monetary policy and the effect of exchange rate pass-through
Authors: Kartaev Ph. S. , Tubdenov V. G.
Published: June 2021

The work is devoted to the study of the influence of changes in the transparencyof monetary policy on the effect of exchange rate pass-through in consumer prices. Based on econometric modeling of cross-country panel data, it is shown that an increase in the transparency of communication between the central bank and the population leads to a decrease in the elasticity of domestic prices with respect to the exchange rate in countries that target inflation and adhere to other monetary policy regimes. The effect is observed for both developed and developing economies; it is stronger in the second case. The obtained result can be interpreted as an argument in favor of the advisability of the Bank of Russia transition from a verbal description of its future actions to the publication of a quantitative forecast of the interest rate trajectory.