bluuebunny/crossref_metadata_2025 huggingface dataset:
ALGORITHMIC SUPPORT OF THE WEB SERVICE RECOMMENDATION SYSTEM FOR LEARNING FOREIGN LANGUAGES
Authors: Bodnar Liliia , Shulakova Kateryna , Gryzun Liudmyla
Published: December 2021

This work is devoted to the analysis of algorithmic support of multimedia content recommender systems and the development of a web service toincrease the efficiency of learning foreign languages using a recommender system that personalized the selection of educational content for the user.To form a list of necessary multimedia content, the main criteria of the recommender system were selected, the basic needs of users were identified,which the system should solve, since increasing the efficiency of learning a foreign language is achieved not only by choosing teaching methods, butalso by watching multimedia content, namely news, films, educational videos, clips, etc. Therefore, in order to form a list of the necessary multimediacontent, the main criteria of the recommender system were formed, the main needs of users were identified, which the system must solve. From theside of the method for implementing algorithmic support, various types of data filtering were considered, from modern technical methods to librariesto ensure the functionality of the system, and the algorithm based on hybrid filtering was chosen, in which known user ratings are used to predict thepreferences of another user. Functional requirements have been developed and a web service has been proposed that allows a comprehensive impact onuser learning when learning a foreign language, software implementation of which is made using Java Script, Python and additional libraries. Thisimplementation allows you to build a process for tracking changes in user requirements and transfer information to the database (DB) and, afteranalyzing the input data, change the proposed multimedia content to the user. In the course of further research, it is planned to conduct practicalexperiments, taking into account the specifics of certain methods of teaching foreign languages and the use of statistical data to assess the effectivenessof the algorithm of the proposed recommender system.
MATHEMATICAL MODEL OF THE DEVELOPMENT OF A SINGLE TWIN LAYER IN METAL CRYSTALS
Authors: Bosin Mark , Gomozov Yevgen , Drygach Tetyana
Published: December 2021

By analyzing the experimental data available in the scientific literature, a mathematical model of the development of a single twin layer in metal crystals has been obtained. The model has the form of a differential equation, the order of which is determined by the required accuracy of obtaining the results associated with the solution of this equation. Even in the linear approximation of one of the main parameters of the phenomenological model, the latter gives qualitatively the same dependences of the development of single twins under different loading conditions compared to the experiment. Despite a large number of experimental works devoted to twinning, there is still no rigorous quantitative theory of the development of twinning layers in different media and under different conditions. However, in these works, the mathematical approach was demonstrated only in relation to elastic twins. This work is an introduction to the creation of a quantitative theory of twinning in metal crystals. Comparisons with the experimental results of the proposed phenomenological model were limited in this work to the task of demonstrating the performance of the model in the sense of predicting the most specific effects of the development of twins under various conditions and loading modes. In particular, the model implies the effect of loss and subsequent restoration of hardening by twin boundaries during stress pulsations, the Bauschinger effect upon a change in the sign of the applied voltage, and a number of other effects observed experimentally on a number of different metal crystals.
PARAMETRIC SYNTHESIS OF A MOVING OBJECT STABILIZER
Authors: Aleksandrov Yevgen , Vanin Viktor , Aleksandrova Tetyana , Vanin Boris
Published: December 2021

The problem of choosing the variable parameters of a stabilizer of an object which minimize an additive quadratic integral functional reflecting the complex of requirements for a closed stabilization system is considered. To solve the problem a combined method of parametric synthesis of the stabilizer, which is a sequential combination of the Sobol grid method and the Nelder-Mead method, is proposed. At the first stage of the method by applying the Sobolev grid method a working point of the closed system in the pace of its variable parameters is transferred into a neighborhood of the quality functional global minimum point. Then at the second stage the Nelder-Mead method is used to relocated the working point into a small neighborhood of the global minimum. The method proposed comprises a particular algorithm for choosing the weight coefficient of the additive quality functional as well as makes use of the stabilization object state vector main coordinates, which provide the most adequate description of its dynamic features. The properties of a mathematical model of controlled system with discontinuous stabilization process control are studied numerically. The analysis of the plots in the dynamical system state phase space indicates non-spiral approach of the system to its equilibrium state. The synthesized control is realized in the form of a sequence of switchovers.
METHOD FOR ELIMINATING ANOMALOUS MEASUREMENTS IN ANALYSIS OF THE MULTI-DIMENSIONAL DATABASE IN SOLVING THE DECISION-MAKING PROBLEM
Authors: Sofronova Maryna
Published: December 2021

The paper proposes a method for eliminating abnormal measurements (outliers) to improve the quality of multivariate data in statistical studies. Such a problem arises, for example, in the theory of managerial decision-making, since when calculating estimates of the parameters of probability distributions, the presence of anomalous (that is, those that significantly increase the confidence interval) measurements in the sample can distort the results of a statistical study, and, consequently, the main problem. The peculiarity of the proposed method is a combination of statistical and geometric methods, namely: the Gestwirt estimation method, the Tukey procedure, and a modification of the method for constructing the convex hull of a finite set of points in a multidimensional space. A set of multidimensional data is associated with a set of points of a multidimensional space. To find and eliminate outliers, a sequence of nested convex hulls, polytopes, is constructed, each of which is described by the intersection of half-spaces (support facets). A detailed algorithm for finding anomalous measurements is given. Their elimination corresponds to the successive elimination of the boundary points of nested convex hulls. The Gestwirt estimate gives the condition for stopping the operation of the algorithm. The proposed method does not require large computational costs and can be widely used in solving both theoretical and practical problems related to the processing of multidimensional data. The numerical results of the method with the number of data components 4 and 5 are presented.
THE EFFECT OF LEADERSHIP STYLE AND MOTIVATION ON THE QUALITY OF WORK LIFE WITH ORGANIZATIONAL COMMITMENT AS INTERVENNING VARIABLES (STUDY AT THE INSPECTORATE OF BOGOR REGENCY)
Authors: Iwan Kurniawan  , Dewi Susita
Published: December 2021

This study aimed to analyze the influence of leadership style and motivation on the quality of work-life and organizational commitment as an intervening variable (study at Bogor District Inspectorate). This research is explanatory. The population in this study were all employees of the Inspectorate of Bogor and the sampling method used was purposive sampling with the number of respondents 90 people. The analytical method used is SEM with Smart PLS. The results showed that the leadership style of a positive and significant effect on the quality of work-life through commitment Bogor District Inspectorate employee organization, motivation and significant positive effect on the quality of work-life through the organizational commitment of employees Inspectorate Bogor,
INSTRUMENT DEVELOPMENT OF HIGHER ORDER THINKING SKILL IN MATHEMATICS INSTRUCTIONAL ON SENIOR HIGH SCHOOL
Authors: Tanujaya Benidiktus
Published: December 2021

The purpose of this research was to develop an instrument that can be used to measure higher-order thinking skills (HOTS) in mathematics instructional of high school students. This research was conducted using a standard procedure of instrument development, from the development of conceptual definition, development of operational definitions, determination constructs, dimensions, and indicators, to the preparation of blue print, item preparation, expert validation, and testing. Data results from trials be analyzed using factor analysis and analysis of structural equation modeling (SEM). The data analysis shows that there are 9 factors HOTS that construct the instrument with good validity and reliability. This instrument classifies high school students in the five categories of HOTS ability. HOTS grouping results can be used by various interested institutions to evaluate the instructional of mathematics. These evaluations are used to determine the success of student learning and the success of teachers' teaching.
A MEANINGFUL BRAIN-BASED LITERATURE LEARNING MODEL
Authors: . ELYUSRA
Published: December 2021

The objective of this research is to design a model of literary study in accordance with students and lecturers needs at the Faculty of Teacher Training and Education in Muhammadiyah University of Bengkulu. This is a research and a developmental study by using the Borg and Gallâ€™s method. It is conducted through identification of students and lecturers' needs toward the models of literature learning, literature review, model design, and validity test from the expertâ€™s judgment. The result of this research was a Meaningful Brain-Based Literature Learning Model which had been validated by two experts. This model covers the components of the plan, implementation, and evaluation.
THE EFFECT OF TUTORING AND CREATIVITY AGAINST STUDENT ACHIEVEMENT OF CLASS XII STUDENTS SMA NEGERI 2 SERANG CITY CIPOCOK JAYA DISTRICT
Authors: Yulida Asri
Published: December 2021

This study aimed to determine (1) Effect of tutoring on student achievement, (2) Influence of creativity on student achievement, (3) Effects of tutoring and creativity of student achievement at the same time. The results of the analysis of hypothesis (1) The correlation value of X1 with Y was 0.6341 with the coefficient of determination was 40.21 %, (2) The correlation value of X2 with Y was 0.5981 with the coefficients of determination was 35.77 %, (3) The correlation value of X1 and X2 with Y was 0.7188 with the coefficients of determination was 51.66 %. Thus, H0 is rejected and H1 is accepted or there was influence of tutoring and creativity on student achievement.
PROGRAM EVALUATION OF THE FREE EDUCATION IN BALANGAN REGENCY
Authors: . Akhriani
Published: December 2021

The research is aimed to investigate and analyze the contexts, input, process, and product of the free education program in the regency of Balangan. The research is an evaluative study by employing a CIPP model of program evaluation by Daniel L. Stufflebeam.The data of the study is collected from various sources which include the Education Department, headmasters, teachers, school committees, parents, students, and schooldocuments. The data is collected by utilizing observation, interview, questionnaire, and documentation.The results of the program evaluation show that: 1) the component of context which include the needs, goals, foundations, and program targets have met the evaluation criteria; 2) the component of input which consists of program plan, program structure, program management, and availability of the finance have met the evaluation criteria however the aspect of manpower particularly in the announcement of the finance that the schools have received, the use of the budget, and the announcement of free education through banners have not met the evaluation criteria; 3) the component of process have not met the evaluation criteria particularly the aspect of check clearing which include the indicator of accuracy of financial revenue to the school account, and the involvement of the school committees in designing the RAPS. On the aspect of budget use is the schoolâ€™s announcement on the plan of financial use in the early of academic year. Meanwhile, on the aspect of budget responsibility is the schoolâ€™s announcement on the use of the BOS/BOSDA in the school announcement boards. On the aspect of monitoring, the BOS/BOSDA management in the regency has analyzed the results of the monitoring whereas on the aspect of supervision the BOS/BOSDA management in the regency has carried out supervision to schools; and 4) the component of product involves the decrease of the numbers of the drop out children have met the evaluation criteria because the free education program has caused a significant effect on the decrease of the numbers of drop outs in the regency of Balangan
EVALUATION OF FIELD JOB P RACTICE IMPLEMENTATION PROGRAM FOR THE STUDENT IS STATE VOCATIONAL HIGH SCHOOL 1 JAKARTA
Authors: Liberna Hawa
Published: December 2021

Implementation of Hammond Model in Evaluation of Field Work Practice Program of State Vocational High School 1 Jakarta. The purpose of this study is to evaluate how the implementation of a program that has been selected in accordance with the purpose of information and implementation of a policy to take a decision. This research is taken one example of Hammond model implementation in Hammond model program evaluation one of program evaluation model that can help change learning to be better seen from 3 aspects that is learning, behavior, and institution. This Hammond program evaluation is a very helpful evaluation of the implementation of an existing school program for the better, in terms of these three aspects. In this research, the researcher evaluates the Field Work Practice program in STMN I Jakarta which has been running for more than 3 years and after the researcher conducted the research at State Vocational High School I many inputs from the researcher about the 3 aspects. And as an acceptable result is the implementation of Field Work Practices in Vocational Secondary School 1 will change its implementation in the first semester IX in the semester V. Because in the semester IX students sufficient knowledge to follow the implementation of Field Work Practices in the field to be better and competence.
THE IMPLEMENTATION OF INNOVATIVE LEARNING MODELS TOWARDS THE SKILL OF STUDENTS SCIENCE PROCESS ON PHYSIOLOGY CLASS
Authors: . Supramono , Rahmaniati Rita
Published: December 2021

This study aimed to examine: (1) the influence of the implementation of inquiry model toward the skill of student science process of Biology Education students of Palangka Raya university, (2) the influence of PBM model toward the skill of student science process of Biology Education students of Palangka Raya university, (3) the influence of GI type cooperative learning toward the skill of student science process of Biology Education students of Palangka Raya university, (4) the difference of influence of inquiry model, PBM, GI toward the skill of student science process of Biology Education students of Palangka Raya university. The design of the research used of pretest and posttest control group design. The sample of the research was the students who take the plant physiology class. The data were collected by written tests and observations about the students' science processes. Unovariate of covariance analysis (anacova) was used in data analysis of learning outcome of science process. The research results showed that there are a significant influence of innovative learning models toward the student science process, which are of inquiry model of score F = 34.978; p = 0.000; PBM model of score F = 24.636; p = 0.000; and cooperative learning model of type inquiry group of score F = 9.361; p = 0.030.
The Assessment Practices by Content-faculty, Student-teaching Supervisor and Cooperating Mentors of Pre-professional Mathematics Teachers in State Universities in Cagayan Valley Region in the Philippines â€
Authors: Oli MARIO Colega
Published: December 2021

Assessment is the process of teachers gathering information about studentsâ€™ learning, including their achievement and behavior in both the cognitive and affective domains enabling teachers to make informed decisions for classroom instruction. The Pre-professional Math Teachers were exposed with various assessment practices during their academic years which were implemented by their Professors across their academic subject and not to exclude Mathematics classes.  Assessment was just regarded as a means for â€œgradingâ€ the mathematical skills and knowledge of the students and not to measure what is worth measuring. This study aimed to determine the assessment practices of content faculty, student-teaching supervisors and cooperating mentors of pre-professional mathematics teachers in State Universities in the Cagayan Valley Region in the Philippines It made used of the qualitative-quantitative research method and utilized questionnaires and semi-structured interview. Frequencies, means, standard deviation, and one-way analysis of variance were used. It was found out that Mathematics content faculty used conceptual class discussions  or recitations, studentsâ€™ calculator and computer use, routine homework or drills, studentâ€™s use of manipulatives to monitor the learning progress of their students while write up of projects, tests (prelim, midterms, finals), and critique papers are utilized for grading purposes. The Student teaching Supervisors always used standard checklist for demonstration teaching, and post-conference and the Cooperating mentors used formal visit and post conference with the Pre-service Math Teachers for formative assessment in assessing the pedagogical skills of the Student teachers during the practicum period. Formal visits, standard checklists for demonstration teaching, and post-conferences with concerned individuals were utilized by both for summative assessment.
THE EFFECT KIND OF WRITTEN TEST AND BELIEF OF MATHEMATIC TOWARD MATHEMATICRESULT
Authors: Iskandar
Published: December 2021

This study aim is to find out the effect kind of written test and belief of mathematic toward mathematic result. The sample in this research is the second grade of vocational school of YPI Way Jepara. The dependent variable is mathematic result and independent variable is kind of written test that are depent to problem solving test and structure exercise method test, and belief of mathematic that are depent to positive and negative category. The instrument that use are mathematic result test and quisioner about mathematic belief. The method used was an quasi experiment method using the treatment by level design 2 x 2. The research hypotheses were tested using two way analysis of variance (ANAVA). The study concluded that mathematic result which the student have positive belief of mathematic is more effective treat by problem solving test, and the mathematic result of the student that
THE IMPLEMENTATION OF TRAINING AND EDUCATION PROGRAM FOR THE HEADMASTER CANDIDATES AT EDUCATION QUALITY GUARANTY INSTITUTION (LPMP) LAMPUNG
Authors: Fardarita  , Ahmad
Published: December 2021

This research was aimed at investigating the reaction, learning achievement, behavior changing, and the effect of training and education program for headmaster candidates by paying attention on institutional, instructional, and behavioral dimension. The research was conducted at the Education Quality Guaranty Institution Lampung. The evaluative qualitative research was applied in this research using blended model of evaluative training model of the Four Levels and the three dimensions cube model. The data was collected by giving questionnaire, observation, interview, documentation, and headmaster candidates’ test results. The result of the research revealed that the purpose of the program was formulated based on the participants’ need, considering the clear qualification of the purpose formulation and the outcome could be observed, the program design described the continuous application strategy dealt with the competence structure, the realization of time, the training and education needed to be improved especially in the use of method, time, management, and the quality of the consumption, the participants’ behavior changing after going back to their working place, the result of the training and education program impacted very much in increasing the school quality, and the appointment of the headmasters considered their competence. As the result of the evaluation, it can be concluded that the headmaster candidates training and education program is categorized good and recommended to be continued with some improvements.
A STUDY ON SELF PERCEIVED ASSESSMENT SKILLS OF BASIC EDUCATION SCHOOL TEACHERS
Authors: Yar Zar Chit
Published: December 2021

The main of this study was to investigate the self-perceived assessment skills of basic education teachers. A total of 228 teachers from primary, middle and high schools (public and private schools) at Pyawbwe Township in Myanmar participated in this study. Descriptive research design and survey method were used in this study.  An instrument: Self-Perceived Assessment Skills Questionnaire was used to collect required data. According to the results, there were significant differences in teachers’ constructing, administering assessment skills, and performance assessment skills by gender at 0.05 levels. Similarly, there were also significant differences in teachers’ grading skills and overall self-perceived assessment skills by gender at 0.01 levels. Besides, it was also found that there were significant differences in teachers’ performance assessment skills and grading skills by school type at 0.05 levels. Moreover, in the comparison of teachers’ self-perceived assessment skills by position, the mean score of junior teachers is the highest and the mean score of primary teachers is the lowest.  Similarly, in the comparison of teachers’ self-perceived assessment skills by service, the mean score of teachers who have above 30-years service is the highest. Finally, this study expects that the school administrators can get any idea to recover and promote the teachers’ assessment skills with the cooperation of experts.
DEVELOPMENT OF ASSESSMENT INSTRUMENTS BASED ON HOTS AT SURABAYA VOCATIONAL HIGH SCHOOL
Authors: Hartono Rudi , Pahlevi Triesninda
Published: December 2021

This study aims to produce assessment instruments according to Higher Order Thinking Skills (HOTS) in General Administration subjects at Basic Competencies 3.9 The Implementation of Office Layout, and 3.10 The Implementation of  Communication in the Workplace as many as 40 items of multiple-choice, and to decide the feasibility level of the questions in measuring students' HOTS based on the validation results from the material expert, evaluation expert, and linguist. This study is Research and Development (R&D) adapted Sugiyono's development model that has been adopted into 5 stages: potential and problems, data collection, product design, design validation, and design revision. Then, the research instruments used by the researcher were the validation sheet from the expert of material, evaluation, and the linguist. Furthermore, the validation result from the material expert was 98.3% (very strong). Besides, the validation result of the evaluation expert was 100% (very strong). Moreover, the validation results from the linguist were 98.7% (very strong). Therefore, the average validation result was 99% with the interpretations of criteria were "very strong" and feasible to use. In conclusion, the development of assessment instruments based on HOTS at Surabaya vocational high school was feasible to use in measuring students' HOTS.

Keywords: An Assessment Instrument Development, General Administration, HOTS.
THE CLINICAL COMPREHENSIVE PRACTICE EVALUATION SYSTEM OF PHYSIOTHERAPY STUDENTS DIPLOMA-IV BINAWAN UNIVERSITY
Authors: Arsyad Noraeni
Published: December 2021

This study aims to describe the problems of the clinical practice assessment system are not in accordance with standards which has an impact on the results of Binawan University Diploma IV physiotherapy graduate. Some items in measuring devices to assess the clinical performance of physiotherapy students have low responsive level. To solve this problem, this study uses descriptive qualitative methods with case study approach that uses various sources of information in gathering data to provide conclusions or detailed descriptions. Data is collected through in-depth interviews with student, clinical instructors and document observations. Data analysis through reduction techniques, presenting data and giving conclusions through triangulation of sources, data and methods by connecting the suitability of relevant theories with the data obtained. The results of the study are generally illustrated the assessment system has been running more focused on case reports, general competency and group comprehensive test assessments. It was found that lack of an independent clinical performance assessment to see individual competencies related to learning outcome from implementation of comprehensive practice physiotherapy clinic. Thus the findings are expected to improve and evaluate the implementation of clinical  comprehensive practice evaluation system of physiotherapy students Diploma IV Binawan University
CONSTRAINTS TO EFFECTIVE CONTINUOUS PROFESSIONAL DEVELOPMENT OF TEACHERS IN GOVERNMENT SECONDARY SCHOOL IN FCT
Authors: Ogunode Niyi Jacob
Published: December 2021

Authentic assessment is a tool of evaluating students learning applicable to real world situation. It is unavoidable tools for modern assessment of learning outcomes. It can be apply as formative or summative assessments or for both assessment types. This paper attempted to examined the concept of assessment and its types, the concept of authentic assessment and its categories, the forms of authentic assessment, the tools used for authentic assessment, methods used in authentic assessment, steps involved in authentic assessment, advantages of authentic assessment, challenges of authentic assessment among others. The paper concludes that it is a high time for authentic assessment to replace traditional methods of assessment in all level of learning. The paper also recommended that the Curriculum Planners should design a curriculum based on types of authentic assessment for all levels of learning, the application of authentic assessment at all levels of learning, time has comes to move from traditional method of assessment to authentic assessment form and required competencies must be possessed by the teacher in order to carry out authentic assessments through proper training
Test Equating with the Rasch Model to Compare Pre-test and Post-test Measurements
Authors: UZUN Zeynep , ÖĞRETMEN Tuncay
Published: December 2021

The purpose of this study is to prove the equitability of pre and post-tests with the Rasch Model and to provide the observability of individual and interindividual ability changes by evaluating the equated tests with stack analysis within the scope of the Rasch Measurement Theory. The pre-test and post-test data that are applied in this study were derived from the project named A Model Proposal to Increase Turkey’s Success in the field of Mathematics in International Large-Scale Exams: Effectiveness of the Cognitive Diagnosis based Monitoring Model No. 115K531, which started on 15/11/2015 and was supported by the TUBİTAK SOBAG 3501 program. The tests were analyzed with the Rasch model, and the fit of the data to the Rasch model was evaluated, and then the Rasch Model and the Separate estimation-Common person method were applied for equating process. Lastly, individual and interindividual ability changes were observed by applying the stack analysis method with the Rasch model. As a result of the analysis of pre and post-tests with the Rasch model, it was concluded that they meet the requirements of the model. As a consequence of the equating process, the equitability of pre-test and post-test was proved, and it was observed that the individual and interindividual ability change could be evaluated by analyzing the pre-test and post-test data with the stack analysis method.
The Impact of a Resident’s Sense of Control on Burnout in Orthopaedic Surgery Residency
Authors: Orman Sebastian , Albright J. Alex , Vutescu Emil Stefan , Eberson Craig P.
Published: December 2021

» Physician burnout is a barrier to the patient-centered approach to health care.

» One of the driving factors of resident burnout is the decreased level of control that residents have over their everyday lives.

» Providing residents with a sense of control over their lives and their jobs increases job satisfaction and leads to a decrease in reports of negative effects on health, rest, participation in extracurricular activities, and time with family.
Optical Biopsy for Esophageal Squamous Cell Neoplasia by Using Endocytoscopy
Authors: Shimoda Yoshihiko , Shimizu Yuichi , Takahashi Hiroaki , Okahara Satoshi , Miyake Takakazu , Ichihara Shin , Tanaka Ikko , Inoue Masaki , Kinowaki Sayoko , Ono Masayoshi , Yamamoto Keiko , Ono Shoko , Sakamoto Naoya
Published: December 2021

Background

Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet undergone histological diagnosis was evaluated. We conducted a surveillance study for patients in a high-risk group of esophageal squamous cell carcinoma (ESCC) and evaluated the in vivo histological diagnostic accuracy of ECS.
Methods

This study was a multicenter prospective study. We enrolled 197 patients in the study between September 1, 2019 and November 30, 2020. The patients first underwent white light imaging and narrow band imaging, and ultra-high magnifying observation was performed if there was a lesion suspected to be an esophageal tumor. Endoscopic submucosal dissection (ESD) was later performed for lesions that were diagnosed to be ESCC by ECS without biopsy. We analyzed the diagnostic accuracy of ECS for esophageal tumorous lesions.
Results

ESD was performed for 37 patients (41 lesions) who were diagnosed as having ESCC by ECS, and all of them were histopathologically diagnosed as having ESCC. The sensitivity (95% confidence interval (CI)) was 97.6% (87.7%-99.7%), specificity was 100% (92.7%-100%), diagnostic accuracy was 98.9% (94.0%-99.8%), positive predictive value (PPV) was 100% (91.4%-100%) and negative predictive value (NPV) was 98.0% (89.5%-99.7%).
Conclusions

ECS has a high diagnostic accuracy and there were no false positives in cases diagnosed and resected as ESCC. Optical biopsy by using ECS for esophageal lesions is considered to be sufficient in clinical practice.
Online Food Delivery Services Among Young Adults in Depok: Factors Affecting the Frequency of Online Food Ordering and Consumption of High-risk Food
Authors: Martha Evi , Ayubi Dian , Besral Besral , Rahmawati Nurul Dina , Mayangsari Aisyah Putri , Sopamena Yoslien , Astari Miranda , Zulfa Resvi Siti
Published: December 2021

BackgroundThe increasing desire of the community towards fulfilling the practical needs of life is currently accommodated by the rapid development of communication technology in the last five years in Indonesia. One example is the emergence of various food delivery applications. This will affect the pattern of daily food consumption in the community. Therefore, this study determined the personal and socio-environmental factors that influence the frequency of online food ordering (OFO) behavior and also high-risk food consumption through online food delivery services (OFDS) among young adults in Depok City. MethodsThis research was a cross-sectional study conducted with 686 participants of young adults aged 20–39 years that lived in Depok City, West Java Province, Indonesia, for minimal the last six months. They were administered a questionnaire through Alchemer, formerly SurveyGizmo. Descriptive statistics were employed for all variables measured. A T-test and a Chi-square test were conducted to determine the factors influencing the OFO frequency and high-risk food consumption through OFDS. Predictor variables were generated using multi-logistic regression models. The predictor for the frequency of OFO behavior was satisfaction toward OFDS (ß = 3.3; CI: 2.4–4.7; p-value = 0.000), while those for high-risk food consumption were personal and socio-environmental factors (ß = 1.8; CI: 1.3–2.5; p-value = 0.001 and ß = 1.7; CI: 1.2–2.4; p-value = 0.001, respectively).ResultsThe personal and socio-environmental factors related to the frequency of OFO behavior were attitudes toward risk, benefit, barriers, features of OFDS, satisfaction with OFDS, socio-environmental influence, perception about OFDS, and online food preference. Furthermore, the factors associated with high-risk food consumption through OFDS were attitudes toward benefit, features, satisfaction with OFDS, socio-environmental influence, perception about OFDS, online food preference, and knowledge of OFDS. ConclusionsSatisfaction, social environment, and food preference play essential roles in OFDS. The findings demonstrated the urgency of conducting further studies to elaborate on the association of OFDS with non-communicable diseases.
Prevalence and Associated Factors of Depression in Outpatients of Internal Medicine Department of Kigali University Teaching Hospital, Rwanda
Authors: Gafaranga Jean Pierre , Bitunguhari Leopold , Mudenge Charles , Kelly Brian
Published: December 2021

Background
Depression is more prevalent in medically ill patients than in the general population. More is not known about depression rates in internal medicine outpatients consulting the teaching hospitals in Rwanda. Adults with medical diseases are more likely to develop depression, it is an often-unrecognized co-morbidity in this group, and it has a major impact on their function and disability. In the absence of studies in our region, we did this research in our country with interest in what factors might be associated with depressive symptoms.
Methods
The descriptive cross-sectional study was used to determine the prevalence of depression and associated factors among internal medicine outpatients of Kigali university teaching hospital (CHUK). The 9 items Patient Health Questionnaire (PHQ-9) instrument was used to screen depression symptoms among outpatients. The validated cut-off score of 10 for diagnosing depression was applied in this study. Patients’ clinical and socio-demographic characteristics were collected and analyzed for their relationship with depression. All patients who scored PHQ-9 above 10 were referred to CHUK mental health department for appropriate management.
Results
Three hundred patients were recruited, of whom 65.3%) were females and 51% had an age between 45 and 96 years. The overall prevalence of depression among outpatients in the internal medicine department of CHUK was 45.7%. Outpatients had 20.7%, 17%, and 10% for moderate, moderately severe, and severe depression, respectively. Age, educational status, and follow-up visits as current physical complaints were independently associated with depression (P < 0.05). As much as 22.7% of patients were presenting with Suicidal ideas. The study showed that low income was strongly associated with suicide ideation (P < 0.001). Regardless of age and gender, the prevalence of depression was higher among outpatients of internal medicine than the general population.
Conclusions
A holistic approach in the management of internal medicine outpatients should be implemented to facilitate the early detection and treatment of depression in general tertiary hospitals. Furthermore, intervention programs that address depression and suicide in adults are needed.
Myomaker and Myomixer Characterization in Gilthead Sea Bream Under Different Myogenesis Conditions.
Authors: Perelló-Amorós Miquel , Otero-Tarrazón Aitor , Jorge-Pedraza Violeta , García-Pérez Isabel , Sánchez-Moya Albert , Gabillard Jean-Charles , Moshayedi Fatemeh , Navarro Isabel , Capilla Encarnación , Fernández-Borràs Jaume , Blasco Josefina , Josep Chillarón , serrana Daniel García de la , Gutiérrez Joaquim
Published: December 2021

The skeletal muscle is formed by multinucleated myofibers originated by waves of hyperplasia and hypertrophy during myogenesis. Tissue damage triggers a regeneration process including new myogenesis and muscular remodeling. During myogenesis, the fusion of myoblasts is a key step that requires different genes’ expression, including the fusogens Myomaker and Myomixer. The present work aimed to characterize these proteins in gilthead sea bream and their possible role in in vitro myogenesis, at different fish ages and during muscle regeneration after induced tissue injury. Myomaker is a transmembrane protein highly conserved among vertebrates; whereas Myomixer is a micropeptide that is moderately conserved but maintains its crucial AxLyCxL motif. myomaker expression is restricted to skeletal muscle, while the expression of myomixer is more ubiquitous. In primary myocytes culture, myomaker and myomixer expression peaked at day 6 and day 8, respectively. During regeneration, the expression of both fusogens and all the myogenic regulatory factors showed a peak after 16 days post-injury. Moreover, myomaker and myomixer were present at different ages, but in fingerlings there were significantly higher transcript levels than in juveniles or adult fish. Overall, Myomaker and Myomixer are valuable markers of muscle growth that together with other regulatory molecules, can provide a deeper understanding of myogenesis regulation in fish.
Polymerized Porin as a Novel Delivery Platform for Coronavirus Vaccine
Authors: Yang Zhongqian , Hua Liangqun , Yang Mengli , Li Weiran , Ren Zhaoling , Zheng Xiao , Chen Haoqian , Long Qiong , Bai Hongmei , Hang Weiwei , Ma Yanbing
Published: December 2021

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), seriously threatens human life and health. The correct folding and polymerization of the receptor-binding domain (RBD) protein of coronavirus in Escherichia coli may reduce the cost of SARS-CoV-2 vaccines. Here, we designed this nanopore by using the principle of ClyA porin polymerization triggered by the cell membrane. We use surfactants to "pick" the ClyA-RBD nanopore from the bacterial outer membrane in this study. More importantly, the polymerized RBD displayed on ClyA-RBD polymerized porin (RBD-PP) already has some correct spatial structures of virus spikes. The nanostructures of RBD-PP can target lymph nodes and promote antigen uptake and processing by dendritic cells, thereby effectively eliciting the production of anti-SARS-CoV-2 neutralizing antibodies and systemic cellular immune responses and immune memory. We applied ofthis PP-based vaccine platform to make an RBD-based subunit vaccine against SARS-CoV-2, which will provide a foundation for the development of inexpensive coronavirus vaccines. The development of novel vaccine delivery system is an important part of innovative drug research. This novel PP-based vaccine platform is likely to be applied to more fields, including other viral vaccines, bacterial vaccines, tumor vaccines, drug delivery, and disease diagnosis.
Inhibition of Salmonella enterica serovar Typhimurium Type Ⅲ Secretion System and Infection Using Small Molecule Quercitrin
Authors: Li Qingjie , Wang Lianping , Liu Shuang , Xu Jingwen , Song Zeyu , Chen Tingting , Deng Xuming , Lv Qianghua
Published: December 2021

AimsThis study was conducted to screen the type Ⅲ secretion system (T3SS) inhibitors of Salmonella enterica serovar Typhimurium (S. Typhimurium) from natural compounds. Through systemic analysis the pharmacological activity and action mechanism of candidate compounds in vivo and in vitro. Methods and resultsUsing an effector-β-lactamase fusion reporter system in S. Typhimurium, we discovered that quercitrin could block effector SipA translocation into eukaryotic host cell without affecting bacterial growth, and inhibit invasion or epithelial cells damage. Using β-galactosidase activity and Western blot assay, it was found that quercitrin significantly inhibits the expression of SPI-1 genes (hilA and sopA) and effectors (SipA and SipC). The animal experiment results indicated that quercitrin reduces mortality, pathological damages and colony colonization of infected mice. ConclusionsSmall-molecule inhibitor quercitrin directly inhibits the founction of T3SS in S. Typhimurium, and provids a potential alternative antimicrobial against Salmonella infection.Significance and impact of the studyNatural compounds have become valuable resources for antibacterials discovery due to their widely structures and biological activities. However, the potential targets and molecular action mechanisms of candidate compounds responsible for anti-infections remain elusive. The T3SS plays a crucial role in bacterial invasion and pathogenesis process in S. Typhimurium. Compared with traditional antibiotics, small molecular compounds can inhibit the T3SS of Salmonella and achieve the effect of anti-infection. They have less pressure on bacterial survival and are not easy to produce drug resistance. This provides strong evidence for development novel anti-virulence drugs against Salmonella infection.
Quantitative Proteomic Analysis of Bi Zhong Xiao Decoction Against Collagen-induced Arthritis Rats in the Early and Late Stages
Authors: He Cailin , Wang Yang , Wen Yuqi , Li Teng , Hu En , Zeng Siqing , Xiong Xingui
Published: December 2021

Background: Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune inflammatory disease. Bi Zhong Xiao decoction (BZXD) performs multiple functions for rheumatoid arthritis (RA) treatment for decades. In this study, we aimed to study the protein alterations of BZXD in the early and late stages of RA.Methods: Sprague-Dawley rats were randomly divided into the Control, collagen-induced arthritis (CIA) and BZXD groups. Clinical assessment, paw thickness, weight changes and serum inflammatory cytokine levels were used to evaluate anti-inflammatory effects. Histopathological tests were performed to assess the improvement of inflammation and synovial hyperplasia. Moreover, we analyzed the proteins profiling of synovial tissue samples with different time intervals after BZXD treatment by Isobaric Tag for Relative Absolute (ITRAQ) quantitative proteomics technology. To further explore the interrelationships among differentially expressed proteins (DEPs), we used DAVID Bioinformatics Resources v6.8 and STRING 11.0 for bioinformatics analysis. Besides, western blot was exerted to verify related proteins.Results: In our study, BZXD ameliorated joint inflammation, suppressed the pathological changes in arthrosis of CIA rats. The proteomic analysis demonstrated that CIA rats were mainly involved in two significant pathways (the focal adhesion and the ECM-receptor interaction) in the early stage. BZXD down-regulated the expression of proteins involved in these pathways, such as CAV1, CHAD, COL3A1, COL5A2, COL6A1 and COL6A5. Additionally, BZXD exerts anti-inflammatory effects in the late stage mainly by increasing the expression of FASN, and affecting fatty acid metabolism.Conclusion: BZXD exerts therapeutic effects on RA through multi-pathways in the early and late stages. This work may provide proteomic clues for treating RA by BZXD.
Dry EEG Measurement of P3 to Evaluate Cognitive Load During Sitting, Standing, and Walking
Authors: Swerdloff Margaret , Hargrove Levi
Published: December 2021

The impact of cognitive load on individuals with motor impairments is poorly understood. Cognitive load has been studied using subjective assessments, dual-task studies, physiological measures, and clinical metrics, which are specific to the motor task being performed and do not measure brain signals directly. Combining brain imaging with dual-task paradigms provides a quantitative, direct metric of cognitive load that is agnostic to the motor task. To better understand the impact of cognitive load during activities of daily living, we measured brain activity from a dry EEG headset as participants attended to an auditory stimulus paradigm during sitting, standing, and walking. The stimulus paradigm consisted of an auditory oddball task in which they had to report the number of oddball tones that were heard during each task. The P3 event-related potential, which is sensitive to cognitive load, was extracted from EEG signals in each condition. Results showed that P3 was significantly lower during walking compared to sitting (p = .039), indicating that cognitive load was higher during walking compared to the other activities. No significant differences in P3 were found between sitting and standing. Head motion did not have a significant impact on the measurement of cognitive load. These results encourage the use of a dry EEG system to further investigate cognitive load during dynamic activities in individuals with and without motor impairments.
Developing Landslide Hazard Scenario of Kashmir Himalaya from the Historical Events
Authors: shah Bilquis , Bhat M. Sultan , Alam Akhtar , Sheikh Hilal , Ali Noureen
Published: December 2021

Kashmir Himalaya being a rugged and tectonically active zone has complex, unstable geology along with steep slopes, creating a favorable environment for landslide hazards, especially along the National Highway (NH-44) that connects the Vale of Kashmir with the rest of India. The historical landslide database for the whole country has not yet been developed and the data provided by various government organizations are often very limited because most of the time local and small-scale landslide events do not get recorded, thus, leading to misinterpretations. The present study focuses on retrieving the information on landslide events and their impacts to develop a comprehensive database for the period from 1990 to 2020 in Jammu and Kashmir, emphasizing Jammu-Srinagar National Highway (NH-44). A hotspot analysis tool (Getis-ord-Gi* algorithm) was used to understand the spatial distribution and concentration of the events throughout the region. The annual and seasonal analysis of the 739 landslide events reported in the valley for the selected period suggests an increasing trend causing 1000 fatalities and 267 injuries. The findings show that out of 20 districts, 16 are relatively more exposed to landslides and the socio-impact induced by landslides was found more along the NH-44 with 303 landslide occurrences reported in 260 days in the past three decades having a high intensity of damage and loss. The results of this study are expected to be of potential use for developing a Landslide Early Warning System (LEWS) and for mitigating the impacts of landslides in the Kashmir Himalaya.
A Novel Decentralized Fixed-Time Tracking Control for Modular Robot Manipulators: Theoretical and Experimental Verification
Authors: Lu Zengpeng , Li Yuanchun , Li Yan
Published: December 2021

This paper presents a novel decentralized fixed-time tracking control approach, which realizes the advantages of modular robot manipulators (MRMs) with fixed-time convergence, strong robustness, and high tracking performance. First, to estimate the total uncertainty of MRMs, the fixed-time observer based on the extended state is developed. Then, combined with the disturbance observer, a novel decentralized control method based on a fixed-time control strategy was devised to accomplish global fixed-time convergence of MRMs. And, stability analysis based on Lyapunov is utilized to obtain the fixed-time stability as well as convergence time of MRMs. Finally, numerical analysis and experiment respectively verify the excellent tracking ability of the presented decentralized fixed-time tracking control.