bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the Antitumor Effect of Chemotherapy with Ocoxin as a Novel Adjuvant Agent to Treat Prostate Cancer
Authors: Hernandez-Unzueta Iera , Benedicto Aitor , Telleria Uxue , Sanz Eduardo , Márquez Joana
Published: May 2023

Prostate cancer is one of the most common cancers among men. Although many patients respond favorably to first-line treatments, castration—and chemotherapy—resistance arises after a few years, leading to metastasis. Thus, new approaches are being investigated using natural supplements to reinforce current therapies. Ocoxin is a plant-based mixture with antitumor properties that have been proved in several cancers. Here, we evaluated the cytotoxic capacity of this compound itself and combined with Docetaxel, Enzalutamide and Olaparib as an adjuvant agent. We observed that Ocoxin reduced tumor cell viability; slowed down cell cycles; altered the expression of genes involved in DNA replication, cell cycles and the p53 signaling pathway; and reduced migratory capacity after stimulation with cancer-associated fibroblasts (CAFs) and osteoblasts in vitro and reduced tumor volume in vivo. The combination of the nutritional supplement with chemotherapy showed a higher cytotoxic effect than chemotherapy alone and reverted chemoresistance conferred by CAFs and osteoblasts. Moreover, the adjuvant therapy also improved the outcome in vivo compared to the treatment with solo chemotherapy, where mice developed smaller tumors and less angiogenesis. Therefore, Ocoxin arises as a good candidate for further studies in combination with current treatments for prostate-cancer patients.
Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents
Authors: Gil-Edo Raquel , Royo Santiago , Carda Miguel , Falomir Eva
Published: May 2023

This work focuses on the development of thirteen benzylethylenearyl ureas and one carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, and cancer ones, such as HT-29, MCF-7 or A-549, on the immune Jurkat T-cells and endothelial cells HMEC-1. Compounds C.1, C.3, C.12 and C.14 were selected for further biological studies to establish their potential as immunomodulating agents. Some of the derivatives exhibited significant inhibitory effects on both targets: PD-L1 and VEGFR-2 in the HT-29 cell line, showing that urea C.12 is active against both targets. Some compounds could inhibit more than 50% of cancer cell proliferation compared to non-treated ones when assessed in co-cultures using HT-29 and THP-1 cells. In addition, they significantly reduced CD11b expression, which is a promising target for immune modulation in anticancer immunotherapies.
Towards a More Efficient In and Ex Situ Conservation of Sri Lankan Wild Rice Species
Authors: Sajeevan Thasajini , Mondoni Andrea , Wijayasinghe Malaka , Jayasuriya Gehan , Kumarage Minindu , Orsenigo Simone
Published: May 2023

Five species of wild Oryza (O. nivara, O. rufipogon, O. eichengeri, O. rhizomatis and O. granulata), including the endemic species O. rhizomatis, have been recorded in Sri Lanka. These species are facing continuous decline in their populations due to natural and anthropogenic processes, with habitat loss being the main threat. This study aimed to provide information on the distribution, the current status of ex situ and in situ conservation, and to identify high-priority species and sites of wild rice in Sri Lanka, in order to improve the effectiveness of conservation efforts. Occurrence records of Sri Lankan wild rice species were collected from literature, gene banks, and field surveys. The distribution of these species was mapped, and areas with high species richness were identified. A gap analysis was conducted to determine the high-priority areas and species for ex situ and in situ conservation. It was found that about 23% of the wild rice populations in Sri Lanka were within protected areas, and by expanding these protected areas by 1 km, an additional 22% of the populations located on the border of these areas could be effectively conserved. Our analysis also revealed that 62% of Sri Lankan wild rice populations were not represented in gene banks. The species-rich areas were found to be in only two districts (Polonnaruwa and Monaragala), and less than 50% of these areas were within protected areas. Based on these findings, O. rhizomatis, O. eichengeri, and O. rufipogon were identified as high-priority species for in situ conservation. Ex situ collections were also deemed necessary for O. granulata and O. rhizomatis to ensure diversity representation in gene banks.
Pigment Biosynthesis and Molecular Genetics of Fruit Color in Pepper
Authors: Wang Linlin , Zhong Yangmin , Liu Jia , Ma Ruifang , Miao Yeminzi , Chen Wenqi , Zheng Jiaqiu , Pang Xin , Wan Hongjian
Published: May 2023

Pepper, as a vegetable crop with a wide cultivation area worldwide, besides being a significant condiment and food, also has a momentous use for chemistry, medicine, and other industries. Pepper fruits are rich in various pigments, such as chlorophyll, carotenoids, anthocyanins, and capsanthin, which have important healthcare and economic value. Since various pigments are continuously metabolized during the development of pepper fruits, peppers exhibit an abundant fruit-colored phenotype in both the mature and immature periods. In recent years, great progress has been made in the study of pepper fruit color development, but the developmental mechanisms are still unclear systematically dissected in terms of pigment, biosynthesis, and regulatory genes. The article outlines the biosynthetic pathways of three important pigments: chlorophyll, anthocyanin, and carotenoid in pepper and the various enzymes involved in these pathways. The genetics and molecular regulation mechanisms of different fruit colors in immature and mature peppers were also systematically described. The objective of this review is to provide insights into the molecular mechanisms of pigments biosynthesis in pepper. This information will provide theoretical basis for the breeding of high-quality colored pepper varieties in the future.
Diurnal Regulation of Leaf Photosynthesis Is Related to Leaf-Age-Dependent Changes in Assimilate Accumulation in Camellia oleifera
Authors: Zhang Jinshun , Zhang Lingyun , Wang Qi , Liu Jiali , Sun Yongjiang
Published: May 2023

In order to clarify the mechanism of diurnal changes in photosynthesis of leaves of different leaf ages in Camellia oleifera, current-year leaves (CLs) and annual leaves (ALs) were used as the test materials to analyze the diurnal changes in photosynthetic parameters, assimilate contents and enzyme activities, as well as structural differences and expression levels of sugar transport regulating genes. The rate of net photosynthesis in CLs and ALs was highest in the morning. During the day, there was a decrease in the CO2 assimilation rate, and this decrease was greater in ALs than in CLs at midday. The maximal efficiency of photosystem II (PSII) photochemistry (Fv/Fm) showed a decreasing trend as the sunlight intensity increased, but no significant difference between CLs and ALs was found. Compared with CLs, ALs showed a greater decrease in the carbon export rate at midday and the levels of sugars and starch increased significantly in ALs, accompanied by higher enzyme activity of sucrose synthetase and ADP-glucose pyrophosphorylase. In addition, compared with CLs, ALs had a larger leaf vein area and higher leaf vein density, as well as higher expression levels of sugar transport regulating genes during the day. It is concluded that the excessive accumulation of assimilate is an important factor contributing to the midday depression of photosynthesis in Camellia oleifera annual leaves on a sunny day. Sugar transporters may play an important regulatory role in excessive accumulation of assimilate in leaves.
Durability of Polymer-Modified Asphalt Mixture with Wasted Tire Powder and Epoxy Resin under Tropical Climate Curing Conditions
Authors: Kim Kyung-Nam , Le Tri Ho Minh
Published: May 2023

The quality of pavements in tropical climates is negatively affected by the frequent wet and dry cycles during the rainy season, as well as by issues related to overloading from heavy trucks and traffic congestion. Contributing to this deterioration are factors such as acid rainwater, heavy traffic oils, and municipal debris. In light of these challenges, this study aims to assess the viability of a polymer-modified asphalt concrete mixture. This study investigates the feasibility of a polymer-modified asphalt concrete mixture with the addition of 6% crumb rubber powder from waste car tires and 3% epoxy resin to counter the harsh conditions of tropical climate weather. The study involved subjecting test specimens to five to 10 cycles of contaminated water (100% rainwater + 10% used oil from trucks), curing for 12 h, and air drying in a chamber of 50 °C for 12 h to simulate critical curing conditions. The specimens underwent fundamental laboratory performance tests such as the indirect tensile strength test, dynamic modulus test, four points bending test, and Cantabro test, as well as the double load condition in the Hamburg wheel tracking test to determine the effectiveness of the proposed polymer-modified material in actual conditions. The test results confirmed that the simulated curing cycles had a critical impact on the durability of the specimens, with the greater curing cycles leading to a significant drop in the strength of the material. For example, the TSR ratio of the control mixture dropped from 90% to 83% and 76% after five and 10 curing cycles, respectively. Meanwhile, the modified mixture showed a decrease from 93% to 88% and 85% under the same conditions. The test results revealed that the effectiveness of the modified mixture outperformed the conventional condition in all tests, with a more prominent impact observed under overload conditions. Under double conditions in the Hamburg wheel tracking test and a curing condition of 10 cycles, the maximum deformation of the control mixture sharply increased from 6.91 to 22.7 mm, whereas the modified mixture increased from 5.21 to 12.4 mm. Overall, the test results confirm the durability of the polymer-modified asphalt concrete mixture under harsh tropical climate conditions, promoting its application for sustainable pavements, especially in Southeast Asian countries.
Dynamic Optimization of Variable Load Process for Combined Heat and Power Unit Based on Sequential Quadratic Programming and Interior Point Method Alternating Solution Method
Authors: Huang Yuehua , Chen Qing , Zhang Lei , Zhang Zihao , Liu Xingtao , Tu Jintong
Published: May 2023

Aiming at the problem that the modeling and solving method of combined heat and power (CHP) unit variable load control process is challenging to meet the demand for efficient analysis of complex systems, this paper proposes a method based on sequential quadratic programming and interior point method (SQP-IPM) alternating solution for dynamic optimization of the CHP unit variable load process. Firstly, by constructing the CHP unit mechanism model, multi-variable coordination control constraints, and output variable process constraints, the dynamic optimization proposition of the CHP unit variable load control process is formed. Then, the large-scale nonlinear programming (NLP) problem formed by using the orthogonal configuration method to discrete the state and control variables is optimally solved using the IPM-SQP alternating solution method. Further, from the perspective of balancing the accuracy of the solution and computational efficiency, the flexible convergence depth control (CDC) strategy is introduced into the alternative solution method to improve the real-time performance of the algorithm. Finally, the variable load control process of 300MW extraction CHP unit is simulated to verify that the proposed method reduces the calculation time for 12 consecutive variable load scenarios by about 70%, effectively improving the real-time performance of scenario applications.
Oppositional Mirror on the Wall: Discursive Practices of Humorous Pashkevilim in Israel’s Ultra-Orthodox Community
Authors: Rosenberg Hananel , Lowenstein-Barkai Hila , Vogelman-Natan Kalia
Published: May 2023

Pashkevilim, printed wall notices posted around Jewish ultra-Orthodox neighborhoods, serve as one of the religious community’s popular communication channels. The Pashkevilim mostly deal with controversial intra-community issues and feature a unique style, extremist rhetoric, and vocabulary derived from the religious literature. Humorous imitations of the genre arose over the years, which circulated in the community and outside of it, posing a challenge to the rabbinic hegemony. Although humorous Pashkevilim have likely been present for as long as Pashkevilim themselves, there is currently a lack of research investigating them. By adopting a critical discourse analysis approach, the current study aims to address this gap by identifying the predominant types of humorous Pashkevilim and analyzing the discursive practices they employ. The findings indicate three main discursive practices that characterize humorous Pashkevilim: parody, satire, and irony. While parody exaggerates the formal characteristics of the genre and mocks them, satire and irony criticize the content and topics discussed in traditional Pashkevilim, especially on the subject of Jewish law and religious stringency. These practices express an oppositional reading of the genre, which challenges its function as well as its socio-cultural, political, and religious significance.
Spatial Validation of Spectral Unmixing Results: A Systematic Review
Authors: Cavalli Rosa Maria
Published: May 2023

The pixels of remote images often contain more than one distinct material (mixed pixels), and so their spectra are characterized by a mixture of spectral signals. Since 1971, a shared effort has enabled the development of techniques for retrieving information from mixed pixels. The most analyzed, implemented, and employed procedure is spectral unmixing. Among the extensive literature on the spectral unmixing, nineteen reviews were identified, and each highlighted the many shortcomings of spatial validation. Although an overview of the approaches used to spatially validate could be very helpful in overcoming its shortcomings, a review of them was never provided. Therefore, this systematic review provides an updated overview of the approaches used, analyzing the papers that were published in 2022, 2021, and 2020, and a dated overview, analyzing the papers that were published not only in 2011 and 2010, but also in 1996 and 1995. The key criterion is that the results of the spectral unmixing were spatially validated. The Web of Science and Scopus databases were searched, using all the names that were assigned to spectral unmixing as keywords. A total of 454 eligible papers were included in this systematic review. Their analysis revealed that six key issues in spatial validation were considered and differently addressed: the number of validated endmembers; sample sizes and sampling designs of the reference data; sources of the reference data; the creation of reference fractional abundance maps; the validation of the reference data with other reference data; the minimization and evaluation of the errors in co-localization and spatial resampling. Since addressing these key issues enabled the authors to overcome some of the shortcomings of spatial validation, it is recommended that all these key issues be addressed together. However, few authors addressed all the key issues together, and many authors did not specify the spatial validation approach used or did not adequately explain the methods employed.
Fully 3D-Printed Dry EEG Electrodes
Authors: Tong Adele , Perera Praneeth , Sarsenbayeva Zhanna , McEwan Alistair , De Silva Anjula C. , Withana Anusha
Published: May 2023

Electroencephalography (EEG) is used to detect brain activity by recording electrical signals across various points on the scalp. Recent technological advancement has allowed brain signals to be monitored continuously through the long-term usage of EEG wearables. However, current EEG electrodes are not able to cater to different anatomical features, lifestyles, and personal preferences, suggesting the need for customisable electrodes. Despite previous efforts to create customisable EEG electrodes through 3D printing, additional processing after printing is often needed to achieve the required electrical properties. Although fabricating EEG electrodes entirely through 3D printing with a conductive material would eliminate the need for further processing, fully 3D-printed EEG electrodes have not been seen in previous studies. In this study, we investigate the feasibility of using a low-cost setup and a conductive filament, Multi3D Electrifi, to 3D print EEG electrodes. Our results show that the contact impedance between the printed electrodes and an artificial phantom scalp is under 550 Ω, with phase change of smaller than −30∘, for all design configurations for frequencies ranging from 20 Hz to 10 kHz. In addition, the difference in contact impedance between electrodes with different numbers of pins is under 200 Ω for all test frequencies. Through a preliminary functional test that monitored the alpha signals (7–13 Hz) of a participant in eye-open and eye-closed states, we show that alpha activity can be identified using the printed electrodes. This work demonstrates that fully 3D-printed electrodes have the capability of acquiring relatively high-quality EEG signals.
Student Stress and the Effects of Relaxation: A Study Conducted at the University of Lille in Northern France
Authors: Gondo Dan , Bernardeau-Moreau Denis , Campillo Philippe
Published: May 2023

Although all sections of society experience periods of stress of varying intensity, there is one population that appears to be particularly vulnerable to stress and its harmful effects: students. Many studies attest to the high level of vulnerability experienced by this young and fragile population, exposed to situations that generate tension, doubt, and stress. Studies estimate that one in three young people suffer from somatic and emotional disorders and have difficulty managing their stress. What can be done about this situation? Based on a representative sample of students enrolled at the University of Lille (Northern France), our study aims to more accurately identify stress levels and factors among the student population. To do this, we conducted three surveys: a qualitative survey consisting of interviews (N = 165), a quantitative survey based on a questionnaire (N = 1049) and an immersive survey where students were invited to take part in an initial relaxation session (N = 22). For the interviews, we used the PSS (Perceived Stress Scale) method of Cohen et al. For the questionnaires, we used the self-administered method (questionnaires sent out and returned by email) with the online application “Survio”. We have thus tried to better assess the impact of sport and relaxation on student stress and determine the extent to which these activities can significantly reduce stress and its harmful effects on the health of young students. Our results show that the main stress factors are exams and uncertainty about the future. The main symptoms of stress are tachycardia and stomach ache. To manage their stress, students prefer to play sports and to go out with friends. Finally, we show a significant correlation between the practice of relaxation and the reduction in stress levels.
The Effects of Massage Therapy on Sport and Exercise Performance: A Systematic Review
Authors: Dakić Miloš , Toskić Lazar , Ilić Vladimir , Đurić Saša , Dopsaj Milivoj , Šimenko Jožef
Published: May 2023

Background: A massage is a tool that is frequently used in sports and exercise in general for recovery and increased performance. In this review paper, we aimed to search and systemize current literature findings relating to massages’ effects on sports and exercise performance concerning its effects on motor abilities and neurophysiological and psychological mechanisms. Methods: The review has been written following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis) guidelines. One hundred and fourteen articles were included in this review. Results: The data revealed that massages, in general, do not affect motor abilities, except flexibility. However, several studies demonstrated that positive muscle force and strength changed 48 h after the massage was given. Concerning neurophysiological parameters, the massage did not change blood lactate clearance, muscle blood flow, muscle temperature, or activation. However, many studies indicate pain reduction and delayed onset muscle soreness, which are probably correlated with the reduction of the level of creatine kinase enzyme and psychological mechanisms. In addition, the massage treatment led to a decrease in depression, stress, anxiety, and the perception of fatigue and an increase in mood, relaxation, and the perception of recovery. Conclusion: The direct usage of massages just for gaining results in sport and exercise performance seems questionable. However, it is indirectly connected to performance as an important tool when an athlete should stay focused and relaxed during competition or training and recover after them.
Measurement Indicators and an Evaluation Approach for Assessing the Sustainable Development Capacity of Tropical Agriculture: A Case Study for Hainan Province, China
Authors: Ye Huichun , Wang Hongye , Nie Chaojia , Wang Jingjing , Huang Wenjiang , Teng Lingling , Wu Mingquan
Published: May 2023

Agriculture is increasingly facing major challenges, such as climate change, the scarcity of natural resources, environmental degradation, labor shortages, and changing societal demands. To meet these challenges, there is an urgent need to move towards more sustainable agricultural practices. The aim of this research was to construct the evaluation index system for the sustainable development of tropical agriculture and evaluate the sustainable development level of tropical agriculture in China’s Hainan Province from 1988 to 2020. Eighteen indicators were selected from the four aspects of agricultural resources, the ecological environment, economic conditions, and social conditions to establish an evaluation index system for the sustainable development of tropical agriculture. A combination of the Coefficient of Variation Method (CVM) and the Index Weighted Method (IWM) was applied to evaluate the comprehensive index of the sustainable development of tropical agriculture. The results of our research indicate that there were significant differences in the level of sustainable agricultural development in Hainan in 2020 across counties and cities, with a downward trend from the central mountainous areas to the surrounding coastal areas. The cities and counties of Wuzhishan, Lingshui, and Qiongzhong had a high level of sustainable development, while Sanya, Dongfang, Wenchang, Qionghai, Ding’an, Danzhou, and Haikou had a low level. From 1988 to 2020, the sustainable development level of tropical agriculture in the province gradually improved, with the highest improvement value of the sustainability index (SI) in Wuzhishan, Wanning, Chengmai, Linggao, and Lingshui and the lowest improvement value of the SI in Baisha, Haikou, and Sanya. Indicators such as the use of agricultural mechanization, construction of farmland infrastructure, improvement of crop productivity, investment in science and technology, and investment in agricultural insurance played a positive role in promoting sustainable development. However, the high use of fertilizers, pesticides, and agricultural films per unit area and the increase in agricultural input prices were not conducive to the sustainable development of tropical agriculture. It is suggested to strengthen the construction and protection of farmland quality, improve the farmland ecological environment, promote agricultural scientific and technological innovation, and formulate feasible policies for the sustainable development of tropical agriculture. The results provide a basic theoretical and methodological reference for achieving Hainan’s sustainable development goals and for assessing the sustainable development capacity of tropical agriculture in similar regions.
Praseodymium(III) Removal from Aqueous Solutions Using Living and Non-Living Arthrospira platensis Biomass
Authors: Yushin Nikita , Zinicovscaia Inga , Cepoi Liliana , Chiriac Tatiana , Rudi Ludmila , Grozdov Dmitrii
Published: May 2023

Praseodymium, the sixth-most abundant rare-earth element, is widely used in the aircraft industry for the elaboration of refractory substances, coloring materials, lighting equipment, and fiber optical cables. Living and non-living Arthrospira platensis biomass was applied for Pr(III) removal from aqueous solutions. In bioaccumulation experiments, the effect of Pr(III), introduced into the medium in a concentration range of 10–30 mg/L, on biomass productivity, biochemical composition, and antioxidant activity was assessed. The biomass showed high accumulation capacity (more than 99%) toward Pr(III). Supplementation of the cultivation medium with Pr(III) led to a decrease in carbohydrate and lipid content, but it did not significantly influence biomass productivity or the content of proteins and pigments. In experiments with non-living biomass, the effect of pH, Pr(III) concentration, temperature, and contact time on the efficiency of metal removal was investigated. The maximum uptake of Pr(III) was achieved at pH 3.0 after 3.0 min of interaction. The equilibrium data were explained using the Langmuir and Freundlich models, while the kinetics of the process was described by applying pseudo-first-order, pseudo-second-order, and Elovich models. The maximum sorption capacity of Arthrospira platensis biomass calculated from the Langmuir model was 99.3 mg/g. According to the thermodynamic calculations, the process of Pr(III) removal was spontaneous and exothermic in nature. The obtained data can be used for the development of environmentally-friendly technology for Pr(III) recovery from wastewater as well as to understand the effect of Pr(III) on aquatic organisms.
Ortaöğretim Kurumlarında Görev Yapan X ve Y Kuşağı Öğretmenlerin Yönetim Algıları ve Yönetimden Beklenti Düzeylerinin Karşılaştırılması
Authors: KARATAŞ Melahat , AKÇA Musa
Published: May 2023

Farklı dönemlerde ortak yargı ve yaşam koşullarında doğan ve ortak paydalarda buluşan nüfus kuşak (Baby Boomer, X, Y, Z ve Alfa) olarak tanımlanmaktadır. Kuşaklar bu ortak paydalar ve çevresel koşullar altında iş hayatından, toplumsal ilişkiler ve tüketim alışkanlıklarına kadar benzer davranışlar göstermektedir. Ekonomik siyasi, sosyal ve kültürel açıdan farklı yaşam koşullarında yetişen kuşaklar arasında ise mesleğe karşı tutum; yeniliklere, değişikliklere karşı istek ve uyum, meslekten ve yöneticilerden beklentiler değişmekte ve farklılaşmaktadır. Farklılıkların yönetimi günümüzde artık gruplara ya da bireylere; ayrım yapmamanın ötesinde bireysel farklılıkları olduğu gibi kabul eden, değerli gören, zenginlik olarak bakan bir anlayışa dönüşmüştür. Eğitim liderlerinin değişen bu anlayışa bakışı ve kabulü iş görenlerin potansiyelini ve dolayısıyla eğitimin kalitesini de belirlemektedir. Bir taraftan toplumsal değişim ve gelişimin temelini oluştururken bir taraftan da değişim ve gelişmelerden etkilenen eğitim kurumlarının liderleri, yönetim politikalarında sürekli bir gelişim anlayışı ile hareket etmek durumundadır. Bu araştırma Ortaöğretim kurumlarında X ve Y Kuşağı öğretmenlerin okul yöneticilerinin yönetimsel uygulamalarına ve farklılıkları yönetim düzeyine ilişkin algılarının farklılaşıp farklılaşmadığını araştırmak amacıyla yapılmıştır. Balay ve Sağlam tarafından geliştirilen ‘’Eğitimde Farklılıkların Yönetimi Ölçeğinin’’, Yönetimsel Uygulamalar ve Politikalar bölümü uygulanmıştır. Çalışma grubunu 2020–2021 eğitim-öğretim yılı Adana Seyhan İlçesinden rastgele seçilen Anadolu lisesinde görev yapan 204 öğretmen içinde X ve Y kuşağına giren 192 öğretmen oluşturmuştur. 16 maddelik 5’ li Likert tipi Farklılıkların Yönetimi Ölçeği (Ölçeğin Yönetsel Uygulamalar ve Politikalar bölümü) ile elde edilen veriler SPSS 26 istatistik paket programında, analize tabi tutulmuştur. Kuşakların ifadelere verdikleri cevapların her biri ANOVA testine tabi tutularak aralarında anlamlı fark oluşturup oluşturmadığı tespit edilmiştir. Genel olarak kuşakların yönetim algı ve beklentileri arasında pozitif yönde, yönetimin eşitlik ve adalet boyutunda ise negatif yönde ilişki olduğu tespit edilmiştir.
Sosyal Medya Savaşlarında Yeni Bir Kavram: Rusya-Ukrayna Savaşı Özelinde Dijital Ambargo
Authors: FİDAN Mustafa , LOKMANOGLU Ensar
Published: May 2023

Makale, merkezine dijital ambargo kavramını almaktadır. Rusya ile Ukrayna arasında yaşanan savaşın bir cephesi olarak öne çıkan dijital medya, savaşın sahadaki sonucuna doğrudan etki etmese de dünya kamuoyunda sürecin algılanması noktasında önemli bir işlev görmüştür. Algı ve propaganda faaliyetleri özellikle savaş dönemi gibi güçlerin çatıştığı ve meşruiyetin yeniden inşa edildiği dönemlerde elzem bir ihtiyaç olarak öne çıkmaktadır; bu doğrultuda medya ve iletişim faaliyetleri de önem kazanmaktadır. Neredeyse tamamı Batı (ABD) kökenli olan sosyal medya mecraları ve dijital uygulamaların, bu süreçte Rusya devletinin iletişim faaliyetlerini propaganda ve provokasyon yapıldığı gerekçesiyle kısıtlaması ve engellemesi birçok tartışmayı da beraberinde getirmiştir. Facebook, Instagram, YouTube, Twitter, Google, Microsoft ve Netflix gibi sosyal medya mecrası ve dijital medya uygulamalarının başta Rusya’yla ilişkili haber kanalları olmak üzere Rusya genelinde faaliyetlerini durdurma, kısıtlama veya engelleme gibi kararlar alması bireylerin bilgi ve haber alma özgürlüğü tartışmasını yeniden gündeme taşımıştır. Küresel anlamda kamuoyu oluşturma, gerçekliği yeniden inşa etme, haber alma ve haberdar etme konusunda neredeyse başat medya konumundaki sosyal medya şirketlerinin, bölgesel savaşlarda siyasal bir duruş sergilediği görülmüştür. Batı’nın müttefiki durumundaki Ukrayna’dan yana tavır alarak Rusya’ya binevi (dijital) savaş ilan eden ve dijital medya uygulamalarının bu tavrı dijital ambargo kavramını ortaya çıkarmıştır. Bir derleme çalışması olan bu makalede, çeşitli örnekler listelenerek Rusya’ya karşı yürütülen dijital ambargo konusu etraflıca değerlendirilmiş ve gelecekteki olası anlaşmazlık, çatışma ve savaşlarda benzer gelişmelerin yaşanması ihtimaline karşı ortaya konulması gereken politikalar tartışılmıştır. Akademik bir kavramdan ziyade güncel politik bir kavram olması itibariyle dijital ambargo kavramının literatür yönünden zayıf kaldığı görülmüş, bu çalışmayla dijital ambargo kavramının literatürde yer alması ve farklı çalışmalarla ile zenginlik kazanacak bir yer edinmesi amaçlanmıştır. Söz konusu bu detay çalışmanın özgün değeri olarak da öne çıkmaktadır.
Delayed parenchymal hemorrhages in the acute period of traumatic brain injury: etiopathogenetic aspects. Literature review
Authors: Pyak A. A. ,   Federal State Budgetary Scientific Institution «N. P. Bekhtereva Human Brain Institute» of the Russian Academy of Science., St. Petersburg, Kholyavin A. I. ,   Federal State Budgetary Scientific Institution «N. P. Bekhtereva Human Brain Institute» of the Russian Academy of Sciences, St. Petersburg
Published: May 2023

The presented literature review is devoted to the pathogenesis of delayed parenchymal hemorrhages in the acute period of traumatic brain injury as the most severe group of patients with high incidence and high mortality. This includes progressing cerebral contusions and delayed intracerebral hematomas. In the literature, there are different viewpoints regarding the determination of prognostic risk factors for the progression of cerebral contusions or in terms of studying the effect of blood pressure on the progression of the injury focus, etc. There is also a lot of disagreement regarding disorders in the coagulation system in TBI. In modern Russian and foreign literature, there are many indicatithat one of the causes of delayed intracerebral hematoma may be hemorrhagic stroke, however, not enough attention is paid to the detailed description of these cases. The purpose of the review is to analyze all the current opinions, disagreements, and perspectives on the etiopathogenesis of delayed parenchymal hemorrhages in traumatic brain injury in order to find the optimal way to influence evolutionary processes in the acute period of severe traumatic brain injury.
Assessment of the impact of the COVID-19 pandemic on the psychological health of the population
Authors: Kameneva A.E. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Vyatkina N.Yu. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow
Published: May 2023

Many researchers are studying various aspects of mental and psychological health of the population during the coronavirus pandemic (COVID-19). Numerous screening studies have been conducted extensively, using various methods of collecting information. These studies indicate that in the current context of the COVID-19 pandemic, there is an increase in the number of cases of anxiety disorders among various social groups.
Erectile dysfunction from the standpoint of comorbidity in vibration disease
Authors: Babanov S.A. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Tatarovskaya N.A. , Kiryushina T.M. , Agarkova I.A. ,   SBHI SR Samara Regional Clinical Geriatric Hospital, Samara,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Samara,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Samara
Published: May 2023

The article presents the data (based on questionnaire results) on the impact of vi bration disease from the exposure to local and general vibration on men’s erectile function. The main changes in the parameters of erectile function (frequency, need, etc.) are described in vibration disease of the first and second degrees from exposure to local vibration, and in vibration disease of the first and second degrees from exposure to general vibration based on the data of a questionnaire survey of male patients and persons in the control group.
Anxiety in vibration disease and comorbidity problems
Authors: Babanov S. A. ,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Baraeva R. A. , Kiryushina T. M. , Azovskova T. A. ,   SBHI SR Samara City Hospital No. 5,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation,   FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation
Published: May 2023

When conducting a comprehensive examination of 145 people with various forms of vibration disease (VD) (first degree VD from exposure to local vibration, second degree VD from exposure to local vibration, second degree VD from exposure to local vibration in combination with hypertension, first degree VD from exposure to general vibration, second degree VD from exposure to general vibration, second degree VD from exposure to general vibration in combination with hypertension) and 30 people in the control group during the integrative anxiety test, an increased level of personal anxiety was revealed in patients with VD, both in the local vibration group and in the group of general vibration, as well as in combination with arterial hypertension (AH), regardless of the vibration type. In the study of the structure of personal anxiety, an increase in the level of the asthenic component of anxiety, emotional discomfort,and prospects assessment of more than 6.0 stanines was found. In the study of situational anxiety, the most pronounced changes in its structure were found in patients with vibration disease in combination with hypertension, regardless of the vibration type. In the structure of situational anxiety in patients with second degree VD from exposure to general vibration and in combination with AH, regardless of the vibration type, the levels of the asthenic component of anxiety and prospects assessment were signifi cantly increased, more than 6 stanines. In patients with vibration disease, both from the impact of local and general vibration and in combination with AH, there is a predominance of destructive psychological defenses (denial and projection) over constructive defenses (compensation and rationalization).
Genetic monitoring of sterlet juveniles (Acipenser ruthenus) in the Volga river
Authors: Makarova E.G. ,   Volga-Caspian branch of VNIRO (CaspNIRKH), Russia, Astrakhan, Kozlova N.V. ,   Volga-Caspian branch of VNIRO (CaspNIRKH), Russia, Astrakhan
Published: May 2023

The aim of the work was to carry out genetic monitoring of the natural reproduction of juveniles (larvae and underyearlings) of sterlet (Acipenser ruthenus Linnaeus, 1958), caught in the middle and lower spawning zones of the Volga River for the period 2021–2022, which is necessary and relevant in the context of a decrease in the number of sturgeon species of fish. The study of fish was carried out according to five nuclear markers and a fragment of the control region of mitochondrial DNA.According to the results of microsatellite analysis, sterlet individuals were characterized by species-specific dominant alleles and high values of the main indicators of genetic diversity: the number of alleles, allelic diversity and heterozygosity, and a slight deficit of heterozygotes was noted. By analyzing of the nucleotide sequences of the mtDNA D-loop region a high level of diversity of maternally inherited haplotypes was revealed, reflecting the number of females involved in natural reproduction. According to the monitoring data, no differences in the distribution and number of identified variants of the D-loop region were registered in the interannual aspect. During the study period, 48 sterlet mitochondrial haplotypes were recorded, of which 18 mtDNA variations were unique, occurring in the Volga-Caspian fishery basin. In the study of sterlet larvae by molecular genetic methods in the Volga River was revealed the process of hybridization between stellate sturgeon and sterlet (Acipenser stellatus × Acipenser ruthenus).
Full-system study of neuroendocrine regulation of fish reproduction. 3. To improve biotech managing methods of valuable fish species reproduction
Authors: Garlov P.E. ,   Saint-Petersburg State Agrarian University, Russia, Saint-Petersburg, Rybalova N.B. , Nechaeva T.A. , Temirova S.U. , Denisenko A.N. ,   Saint-Petersburg State Agrarian University, Russia, Saint-Petersburg,   Saint-Petersburg State Agrarian University, Russia, Saint-Petersburg,   Saint-Petersburg State Agrarian University, Russia, Saint-Petersburg,   Saint-Petersburg State Agrarian University, Russia, Saint-Petersburg
Published: May 2023

According to presently used biotechnics of salmon farm reproduction, producers are withdrawn (fishing out) from spawning (fish spawning grounds), and the survival rate of one-year-old farmed juveniles in nature (in the form of “spawning return”) is half of the standard. To exclude these most important biotech imperfections, a new biotechnological approach based on the identification and use of species potencies of reproduction, survival and growth in an adequate species-specific complex of optimal habitat conditions are developing. The purpose of our full-system research is to develop effective biotechnics for the artificial reproduction of salmon fish populations in the North-West. To refine the previously developed basic full-system method of reproduction of salmon and sturgeon fish populations to the possibility of its industrial use is the main task of the work. The new “Method for production offspring of sturgeon and Atlantic salmon in seawater” includes the maintenance of brood-stock and the production of offspring of migratory fish in a wide range of salinity of the brood pond. To do this, at the onset of spawning temperatures, producers are sorted according to the degree of readiness for spawning and physiological (hormonal) stimulation of the mature producers gonads maturation are carried out with a natural hormonal preparation — an isolated anterior pituitary lobe, in established species temperature-dependent doses. And immature producers are subjected to environmental (ecological) stimulation of maturation by a periodic influx of fresh water and, upon reaching readiness for spawning, they are stimulated by preparate of the isolated anterior pituitary lobe. The method provides the efficiency increase of natural and artificial reproduction of migratory fish by expanding the possibilities of obtaining offspring from producers in the marine habitat.
Risk management in business: strategies and techniques for preventing losses and ensuring sustainable development
Authors: Mikryukov D. N. ,   Bio-Rad Laboratories, Moscow
Published: May 2023

This scientific article provides an analysis of various types of risks that organizations encounter in the business fi eld and explores strategies and methods for managing these risks. The article thoroughly examines fi nancial, operational, reputational, and legal risks, with a focus on detailed descriptions of each type and their associated consequences. The author analyzes various methods for risk analysis and management, such as developing risk management strategies, establishing monitoring and control programs, utilizing insurance and diversification, managing human resources, implementing technology, and other approaches. Each method is studied with the inclusion of practical examples of successful implementation and a detailed discussion of their advantages and limitations. The research also includes an analysis of statistical data related to each type of risk, aiming to provide an objective understanding of the likelihood and impact of each risk type on business processes. Based on the analysis conducted, conclusions are drawn regarding the necessity of a comprehensive approach to risk management in business and the signifi cance of each risk type in ensuring the success and sustainability of an organization. The article off ers valuable scientifi c foundations and recommendations for managerial practice, emphasizing the importance of effective risk management and the need to take appropriate measures for risk minimization and control within the context of the modern business environment. As a result of the research presented in the article, the necessity of a comprehensive approach to risk management in the business field is emphasized. The author has discovered that each type of risk — financial, operational, reputational, and legal — has its unique characteristics and potential implications for an organization.
Kur’ân Metnine İlave İddiası (Kur’ân Meâlî ve Yorumu Adlı Meâl Örneği)
Authors: KAYIŞ Mahmut
Published: May 2023

Kur’ân-Kerîm, bütün insanlığın hidâyeti için gönderilmiş Arapça bir kitaptır. Onun evrensel mesajının dili Arapça olmayan toplumlar tarafından da anlaşılması gerekmektedir. Bu amaca matuf olarak ülkemizde Kur’ân çevirileri yapılmakta ve bunların sayısı günden güne artmaktadır. Bazı çeviriler, üzerinde ciddiyetle durulması gereken problemlerle meâl dünyasına katılmaktadır. Bu çalışmada, Aydın Sevin’in “Kur’ân Meâli ve Yorumu” adlı eserinde dile getirdiği “Kur'ân metnine ilavelerin yapıldığı iddiası” incelenmiştir. İlgili eserde, Hz. Peygamber’in (s.a.v.) vefatından sonra bir kısım sahâbînin ibadet ve muamelâtla ilgili bazı âyetleri Kur'ân’a ekledikleri savunulmaktadır. Çalışmamızda önce Kur’ân metnine müdahale edildiğine yönelik tarihsel süreçte ortaya çıkan şâz görüşler, genel manada incelenmiştir. Ardından ilgili meâlde bu hususta ileri sürülen argümanlar, Kur'ân metninin ortaya koyduğu mana, Hz. Peygamber’in (s.a.v.) uygulamaları ve tarihsel veriler bağlamında mukayeseli olarak analiz edilmiştir. Bu çalışmayla Kur’ân’ın korunmuşluğuna halel getiren bahse konu iddiaların ilmi değerinin ortaya konulması amaçlanmış olup bunların meâl kültürümüzde ve toplumun Kur'ân algısında meydana getirebileceği olumsuz etkinin azaltılması da hedeflenmiştir.
الضوابط التفسيرية التي استمدها ابن رشد من الطبري في تأويله الفلسفي للقرآن الكريم تجربة لقراءة التأويل الفلسفي بين الحداثة والبرهان
Authors: MAHMOOD Rawad Mohammed
Published: May 2023

انشغل هذا البحث بدراسة أهمية التفسير في إنجاز فعل المقاربات الفلسفية للنصوص الدينية. أي الكشف عن أثر منهج الطبري (310/923)، في منهج ابن رشد (595/1198)، الفلسفي. وتتبع القواعد والأصول التفسيرية والمفاهيم التي استمدها من "جامع البيان" في تأويله الفلسفي للقرآن الكريم. ولهذه الخطوة الأثر الكبير في الكشف عن الإمكانات التي توفرها علاقة الفلسفة بالتفسير منهجاً ومضموناً. وقد بدت آثار منهج الطبري واضحة في تعاملات ابن رشد مع النص. وموقفه الفلسفي من التراث. وبالرغم من اعتقاد الدراسات الحداثية بتقليدية الطبري في التأويل إلا أن ابن رشد قد استفاد منه في تأويل العلاقة بين الدين والفلسفة. وأنشأ عن هذه العملية اتصال دائم بين الفلسفة والتفسير. وأسس لحداثة برهانية مستدامة. وتأمين غطاء آمن للعقل. غطاء يبقيه في وضع النشاط والقدرة على الاتصال الدائم بالوحي. وهذا الاتصال هو المسؤول عن إنجاز المقاربات الحديثة التي يريد الوحي تحقيقها في ذهنية العقل المعاصر. فلا وسيلة غير البرهان للاتصال بالوحي. ولا فعل غير فعل الفلسفة والتفسير قادر على حدوث الاتصال. وقراءة مصاديق المفاهيم بما يتناسب ومعطيات العقل الذي يتطلع بآماله نحو عالم يليق بتوسعه.
Improving teaching practice using peer observation of teaching while participating in a Community of Practice
Authors:   , Staples James
Published: May 2023

This paper discusses research that was conducted at the Otago Polytechnic Auckland International Campus with the aim of creating a programme for peer observation of teaching. The motivation for the research was to discover a process for lecturers to feel empowered in developing their facilitation practice through a sustained sharing of ideas, and to foster a greater culture of collegiality among teaching staff. Participants in the research project engaged in multiple rounds of peer observation of teaching over the course of a teaching block on the campus, during which each participant acted as both classroom observer and observee. To foster the sharing of practice, participants were also placed into a community of practice where they would discuss their experiences after each round of observation. The feedback from the participants was used to determine if the structure of the programme would be acceptable for a wider implementation of such a project. Participative action research was selected as the methodology, as this allowed for the participants and the researcher to work together in determining the process and for the participants to have the freedom to operate in a method that suited their own practice. Key findings from the project included that the use of a community of practice was instrumental in getting facilitators to share their practice and engage in sustained observations of teaching in a mutually beneficial manner, and that lecturers need to be given a level of autonomy in how they manage their observations for them to feel empowered in their own development of practice. The results from this study can be used to develop similar peer observation processes across Otago Polytechnic.