bluuebunny/crossref_metadata_2025 huggingface dataset:
The City Has Abandoned Geometry: The Countryside Has Not! Reflections on Geometry and Its Teaching from the Perspective of Countryside Education
Authors: Fernandes Filipe Santos , Grossi Flávia Cristina Duarte Pôssas , Martins Maria de Fátima Almeida
Published: April 2023

Background: On the one hand, the history of mathematics teaching in Brazil is marked by the gradual abandonment of Geometry teaching; on the other hand, the countryside has always assumed it as an essential ally in the political and identity affirmation of its populations. Objectives: This paper discusses how Geometry and its teaching can emerge, in the paradigm of Countryside Education, as a possibility of political-epistemic disobedience to a Mathematics Education referenced in the knowledge, procedures, attitudes, and values of urban, industrial, and market forms of life. Design: The research uses qualitative methodology with a focus on Countryside Education. Setting and participants: The investigation was developed in the context of an Undergraduate Teaching Degree in Countryside Education, based on records of students' activities. Data collection and analysis: The text mobilizes formative experiences of a degree in Countryside Education with emphasis on Mathematics to reflect on how Geometry can be articulated to rural peoples' territories and territorialities, aiming to contribute to pedagogical guidelines for teaching K-12 Mathematics. Results: The paper contributes to evaluating epistemological and educational positions regarding Geometry and geometric knowledge commonly established by school cultures, not necessarily limited to schooling in rural regions. Conclusions: Geometry in school cultures can be used to understand the social reality in which subjects, communities and collectives are inserted, mapping inequality relations, and proposing ways to overcome them.
Desfecho de pacientes coinfectados pelo vírus da imunodeficiência humana e o novo coronavírus: Revisão Integrativa
Authors: Vaz Peixoto Silva Vitória Vivian , Bomfim de Almeida Jéssica
Published: April 2023

Introdução: O novo coronavírus surgiu na cidade de Wuhan, na China, e se espalhou rapidamente por vários países, sendo considerado uma pandemia. Essa doença leva a diversos sintomas que normalmente são agravados em pessoas que possuem algum tipo de comorbidade e/ou são imunossuprimidas, como as pessoas que vivem com HIV/AIDS. Objetivo: Avaliar na literatura científica o desfecho e as características clínicas de pessoas portadoras de HIV quando coinfectadas pelo SARS-CoV-2. Métodos: Foi realizada uma revisão integrativa de estudos publicados nas bases de dados PubMed e LILACS em . Foram identificados 127 estudos e destes foram incluídos 16 artigos para análise. Os dados demográficos e clínicos de 616 pacientes foram coletados e inseridos no software Microsoft® Office Excel 2016; dessa forma, as variáveis contínuas foram resumidas usando média e desvio-padrão e as variáveis categóricas, por frequência e porcentagem. Resultados: Do total de indivíduos incluídos no estudo, 82,6% dos participantes eram do sexo masculino e 51,6% possuíam algum tipo de comorbidade; além disso, 84,6% apresentaram algum tipo de sintoma relacionado a COVID-19. Apesar disso, 66% faziam uso de antirretrovirais e 87% estavam com contagem de linfócitos T CD4 + maior que 200 células/µL. Ademais, o quadro clínico da COVID-19 variou de leve a moderado em 77% dos pacientes, que em sua maioria (96,6%) evoluiu para a cura. Conclusão: O desfecho clínico dos pacientes coinfectados por HIV/SARS-CoV-2 é favorável, visto que mais de 90% dos participantes evoluíram para a cura, mesmo aqueles que tinham algum tipo de comorbidade associada e/ou apresentaram sintomas clínicos da doença.
Indicações de traqueostomia em uma unidade de terapia intensiva
Authors: Da Silva Nascimento Tainara , Braga Arcanjo Ana Beatriz , José Fernandes Murilo
Published: April 2023

Introdução: A traqueostomia é um procedimento cirúrgico e uma alternativa mais segura para os pacientes com tempo de intubação prolongado ou falha no desmame ventilatório, pois facilita o desmame, possibilitando um menor tempo de ventilação mecânica. Objetivo: Documentar os pacientes em ventilação mecânica invasiva que necessitaram de traqueostomia e verificar a relação do procedimento com a clínica dos pacientes que foram a ele submetidos. Métodos: Pesquisa quantitativa, descritiva e transversal realizada a partir da coleta de dados de prontuários de pacientes submetidos a traqueostomia em uma Unidade de Terapia Intensiva (UTI) durante os meses de novembro de 2019 a agosto de 2020. Resultados: Foram incluídos 67 pacientes de ambos os sexos internados em uma Unidade de Terapia Intensiva que permaneceram sob intubação orotraqueal por 48 horas ou mais, divididos em dois grupos: cirúrgico e clínico. Em relação aos dias de ventilação mecânica antes da traqueostomia, esse período foi menor no grupo cirúrgico do que no grupo clínico (respectivamente: mediana = 8 e 12,5 dias; intervalo interquartil 6-12 e 8-14,5; p=0,0109). A principal indicação do procedimento no grupo cirúrgico foi de traqueostomia precoce por diagnóstico com perspectiva de ventilação mecânica prolongada (42,4%) e na clínica foi de nível de consciência inadequado para extubação (47,1%). Não houve diferença entre os grupos (p=0,3102) quanto aos dias de ventilação mecânica após o procedimento, grupo cirúrgico (mediana = 5 dias; intervalo interquartil 2-8) e grupo clínico (mediana = 4 dias; intervalo interquartil 2-7). Conclusão: Nível de consciência inadequado para extubação e opção por traqueostomia precoce em patologia com perspectiva de ventilação mecânica prolongada foram as principais indicações do procedimento em nossa Unidade. O tempo de ventilação mecânica invasiva antes da traqueostomia foi maior no grupo de pacientes clínicos do que no grupo de pacientes cirúrgicos.
Review of Factors Affecting Remission in Narcological Patients
Authors: Agibalova Tat'yana V. , Nobatova Viktoriya N. , Tuchina Ol'ga D. , Leonov Egor V. , Pinegin Aleksandr R. , Tukhvatullina El'mira I.
Published: April 2023

INTRODUCTION: Achievement of a sustained remission in patients with substance dependence syndrome is the main criterion of the quality of narcological treatment and a priority treatment task. The article presents a review of factors that influence remission in patients with mental and behavioral disorders resulting from use of psychoactive substances. Studies performed in the recent 15 years, consider the main five groups of factors for development and failure of remission: biological (gender, age, genetic parameters, organic lesions of the brain, etc.), narcological (course of the disease, age at the first use of a drug), personality and pathopsychological (cognitive disorders, comorbid mental disorders, mental trauma, etc.), social (employment, family and social situation, social support, etc.) and therapeutic factors (duration and methods of treatment, therapeutic alliance, etc.)..
CONCLUSION: There are basic factors of favorable prognosis of the course of narcological diseases that are confirmed from study to study: late onset of the disease, absence of a comorbid dependence syndrome and of a severe mental disorder, involvement in long-term treatment and rehabilitation programs that continue after remission.
Role of Myocardial Bridging in Myocardial Ischemia: Case Report
Authors: Solov'yeva Aleksandra V. , Gurbanova Arzu A. , Maksimtsev Ivan A. , Lazareva Oksana Yu. , Maksimtseva Elena A.
Published: April 2023

INTRODUCTION: Myocardial bridging (MB) is considered a benign pathology, however, its existence is often associated with angina pectoris, myocardial infarction, ventricular tachycardia and sudden cardiac death. The clinical significance of MB is determined by the dynamic stenosis of the coronary artery, which depends on the rate and strength of heart contractions and is poorly visualized by instrumental methods, which impairs timely diagnosis and early administration of the adequate treatment. A clinical case of a combined damage to the coronary bed in a 58-year-old patient is presented: MB of the anterior interventricular artery (AIVA) causing dynamically significant narrowing of the tunnel artery and hemodynamically insignificant atherosclerotic lesion of the coronary arteries. MB was typically located in the mid-segment of the AIVA. The diagnosis of the anomaly of the coronary bed was established after coronary angiography: MB of AIVA led to stenosis of the tunnel segment to 80% and was the cause of angina attacks. Stenting of the AIVA with a drug-coated stent was performed. The effectiveness of the stenting can be referred to a peculiar feature of this case, since in the treatment of this pathology the preference is given to myotomy and coronary artery bypass grafting as more effective methods. The follow-up period was 7.5 years; after stenting of the tunnel segment of the AIVA the anginal attacks did not recur.
CONCLUSION: The described clinical case demonstrates the role of MB in the development of myocardial ischemia. With timely diagnosis of the coronary blood flow disorders, successful revascularization and adequate pharmacotherapy in accordance with the current clinical recommendations, the prognosis is good.
Peculiarities of Brain Hemodynamics and Heart Rhythm Variability in Young Men in Performing Modeled Cognitive Activity with Unequal Effectiveness
Authors: Kulagin Pavel A. , Lapkin Mikhail M. , Trutneva Elena A.
Published: April 2023

INTRODUCTION: Purposeful cognitive brain activity of an individual depends on blood supply to the cells of the cerebral cortex (CC), and on their autonomic innervation.
AIM: To identify peculiarities of the brain hemodynamics and heart rhythm variability (HRV) in young men performing cognitive tasks with unequal effectiveness.
MATERIALS AND METHODS: The study involved 42 practically healthy young men (mean age 19.40 1.20 years). The brain hemodynamics was studied using Reo-Spektr-2 rheograph (Neurosoft, Russia) in the initial condition of relative rest and in modeled purposeful cognitive activity. Synchronously with record of rheoencephalogram, rhythmocardiogram was recorded using Varicard 2.51 hardware-software complex (Ramena, Russia). Purposeful cognitive activity was modeled in Physiotest program for psychophysiological studies with use of behavioral model: Schulte Table Test in a two-color SchulteGorbov modification. In statistical data processing, cluster and correlation analyses were used.
RESULTS: Based on the effectiveness of SchulteGorbov Table Test, the sample of subjects was divided to two clusters (n = 28 and n = 14). Comparison of clusters in the initial condition of relative physiological rest and during cognitive activity revealed differences in rheoencephalographic parameters, which reflects unequal hemodynamic supply of the brain in representatives of the given clusters. Differences in HRV parameter were found reflecting the different levels of tension of adaptation mechanisms in the initial condition and in cognitive activity. The results of the correlation analysis demonstrated different dependence between the parameters of rheoencephalogram, HRV and parameters of the effectiveness of Schulte-Gorbov Test in representatives of different clusters.
CONCLUSIONS: (1) High-effective subjects are characterized by shorter time of propagation of the rheographic wave and longer time of slow blood filling of the right vertebral artery basin, and by higher rheographic index asymmetry coefficient in the basin of the left internal carotid artery and of vertebral arteries of both hemispheres during cognitive activity compared to low-effective subjects. (2) Physiological support of purposeful activity of an individual with unequal effectiveness of salvation of cognitive tasks is characterized not only by different levels of brain hemodynamics and activity of autonomic regulatory mechanisms, but also by certain type of correlation relationships of these parameters with parameters of purposeful behavior, in particular, with the total time of fulfilment of the task and efficiency coefficient.
Combined Effect of Multimorbidity and Increased Body Mass Index on Control of Bronchial Asthma and Quality of Patients’ Life
Authors: Tribuntseva Lyudmila V. , Avdeyev Sergey N. , Budnevskiy Andrey V. , Prozorova Galina G. , Kozhevnikova Svetlana A.
Published: April 2023

INTRODUCTION: Bronchial asthma (BA) is a serious medical and social problem due to its increasing prevalence, significant burden on healthcare and the persisting high level of disability and mortality.
AIM: To study a combined effect of multimorbidity and increased body mass index (BMI) on BA control and quality of life (QL) of patients to determine the possibilities of optimization of personalized program of patient management.
MATERIALS AND METHODS: Two hundred thirty seven patients with BA were divided to 3 groups: 1 with normal body weight (n = 59; 24.9%); 2 with overweight (n = 69; 29.1%); 3 with obesity (n = 109; 46.0%). The level of multimorbidity was analyzed by Charlson comorbidity Index (CCI) and the cumulative illness rating scale (CIRS); BA control by ASTTM and ACQ-5; QL by AQLQ. The average number of groups of comorbid diseases (according to CIRS) was 7.44 0.95, while 13.5% of patients had 12 groups of comorbid diseases, 33.8% 34 groups, 46.8% 5 groups. In the group of obesity, 82.6% of patients had 5 groups of diseases. The average score of CIRS index was 7.44 0.95 points, the maximum score was 19, the minimum was 2. In the first group, the average value of CIRS index was 4.68 0.31 points, in the second 5.62 0.43 points, in the third 10.1 1.9 points (p1, 2 = 0.001, p1, 3 0.0001, p2, 3 0.0001).
RESULTS: Ten patients (4%) had fully controlled BA by АСТ and 33 (14%) by ACQ-5. In the group with obesity, controlled BA was not detected (2 = 34.128; p = 0.0002), (F = 41.362; p 0.001). With increase in the number of comorbid diseases, the control of BA reliably decreased; thus, in groups 2 and 3 with the existence of 5 groups of comorbid diseases, asthma had uncontrolled course with the lowest parameters in patients with obesity (р 0.05). Analysis of BA by AQLQ showed negative influence of the disease on the severity of symptoms, motor activity, general QL of patients with obesity. The data obtained are confirmed by the correlation analysis.
CONCLUSION: Multimorbidity negatively influences control of BA: increase in CCI and CIRS parameters considerably impairs control of BA. Increase in BMI is a significant additional risk factor of impairment of BA control. Multimorbidity in combination with obesity significantly impairs QL of patients with BA according to AQLQ. The absence of control of BA according to АСТ and ACQ-5 influences the quality of life of patients with BA. The evaluation of multimorbidity and BMI must be included in the personalized program for management of patients with BA to take into account multivariate assessment of treatable signs of the disease.
Disease-Specific Treatment For Primary Membranous Nephropathy: The Role of Monoclonal Antibodies
Authors: Ruggenenti Piero
Published: April 2023

Primary Membranous Nephropathy is an autoimmune disease caused by the deposition of Immunoglobulin G and complement components on the subepithelial layer of the glomerular capillary wall. It affects 5-10 patients per million population and is the second cause of nephrotic syndrome in adults after diabetic kidney disease. For decades steroids and non-specific immunosuppressive medications have been advocated as a therapeutic option for patients with membranous nephropathy at increased risk of kidney failure because of persistent nephrotic syndrome. These medications, however, have major and potentially fatal adverse effects that offset their potential benefits and should be abandoned. The discovery of nephritogenic autoantibodies against podocyte M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) antigens provided a clear pathophysiological rationale for interventions specifically targeting B cell lineages to prevent antibody production and subepithelial deposition. The first-in-class anti-CD20 monoclonal antibody rituximab is safe and achieves remission in approximately two-thirds of patients with nephrotic membranous nephropathy. In PLA2R-related disease, remission is invariably preceded by depletion of anti PLA2R autoantibodies and relapse by their re-emergence into the circulation. Because of its superior risk/benefit profile as compared to non-specific immunosuppressive therapy, rituximab is now first-line therapy for patients with membranous nephropathy at risk of kidney failure. Novel monoclonal antibodies targeting CD20 cells (such as ofatumumab and obinutuzumab) and their differentiation (belimumab) or targeting long-living antibody producing CD38 memory cells (daratumumab, felzartamab) along with proteasome inhibitors such as bortezomib are being evaluated for the treatment of nephrotic patients with membranous nephropathy who are resistant or intolerant to rituximab. Complement inhibitor therapy might serve to stop the glomerular inflammatory process until the benefits of these medications become effective. Thus, major advances in the understanding of the mechanisms of membranous nephropathy have led to novel treatment perspectives. The integrated evaluation of serum autoantibody titer and proteinuria, together with serum albumin levels in patients with overt nephrotic syndrome, could guide diagnosis of membranous nephropathy and individually tailored treatment protocols. The introduction of monoclonal antibodies targeting disease-specific mechanisms will pave the way for a novel therapeutic paradigm based on the principle of precision medicine and personalized therapy.
Are Vitamin D Supplements an Adequate Substitute for Sun Exposure?
Authors: Hoel David , Miller Allen
Published: April 2023

It is becoming well understood that low blood levels of 25-hydroxyvitamin D (25(OH)D) are a risk factor for many diseases and other adverse health effects including hypertension, cardiovascular disease, stroke, breast cancer, colorectal cancer, metabolic syndrome, type 2 diabetes, obesity, multiple sclerosis, type 1 diabetes, rheumatoid arthritis, Alzheimer’s disease, autism, schizophrenia, asthma, preterm birth, maternal mortality, myopia and COVID-19. Levels of serum 25(OH)D are at the same time a measure of vitamin D status and, since 70-90% of this biomolecule is produced by sun exposure, a measure of sun exposure. There is some disagreement among scientists as to whether vitamin D supplements are an effective substitute for sun exposure for attenuation of these diseases and adverse health effects. In this paper we review the current state of the science on this subject and conclude that vitamin D supplements are not an adequate substitute for sun exposure for attenuation of most of these diseases and adverse health effects, particularly hypertension and cardiovascular disease, and should not be recommended in lieu of sun exposure to patients presenting with low levels of serum 25(OH)D. Vitamin D supplementation for such patients could even be harmful, because it will raise patients’ serum 25(OH)D levels, thereby giving patients a false sense of security and obscuring the best available metric for insufficient sun exposure.
Analysis of Bevacizumab Activity Following Treatment of Patients with Ovarian Cancer or Glioblastoma
Authors: Lallemand Christophe , Ferrando-Miguel Rosa , Pauli Franziska , Deisenhamer Florian , Tovey Michael
Published: April 2023

Highly sensitive reporter-gene assays have been developed that allow the precise quantification of both the direct vascular endothelial growth factor-A neutralizing activity of bevacizumab and the ability of bevacizumab to activate antibody dependent cellular cytotoxicity. The use of these assays to analyzes samples from patients with ovarian cancer following four cycle of bevacizumab treatment revealed a close correlation between bevacizumab neutralizing activity and antibody dependent cellular cytotoxicity activity, and a reasonably good correlation between both activities and circulating drug levels determined using an enzyme-linked immunosorbent assay. Analysis of longitudinal samples from a small cohort of patients with glioblastoma treated with bevacizumab revealed a lower correlation between these parameters. We report herein that reanalysis of the grouped samples from the two studies using the nonparametric Spearman rank correlation coefficient revealed a surprisingly good correlation between the two facets of bevacizumab activity, and between both activities and circulating drug levels despite the different indications and treatment regimens, revealing new insights into the action of bevacizumab in neoplastic disease.
Anatomical and visual outcome of vitrectomy for giant retinal tear detachment with proliferative vitreoretinopathy: A retrospective, consecutive case series
Authors: Okonkwo Ogugua , Hassan Adekunle , Onyeaso Obinna , Akanbi Toyin , Komolafe Rhoda
Published: April 2023

Aim: To report the anatomical and visual outcome of giant retinal tear (GRT) associated retinal detachment (RD) with advanced proliferative vitreoretinopathy (PVR) and determine the effect of presenting clinical and surgical variables Method: Retrospective, non-comparative, consecutive, interventional case series of vitreoretinal surgeries performed in a private tertiary eye unit. Patient demographics, preoperative, and intra-operative variables were assessed and analyzed. Inclusion: Eyes which had surgery for previously unoperated GRT RD with PVR and had > 3 months of follow up. Exclusion: Other primary and secondary forms of RD with no GRT. Results: Thirty-six eyes of 36 patients were evaluated. Male: female ratio = 5:1. Mean age of 45.53 ± 13.2 years (range 12 - 65 years). Left eye, twenty-three eyes (63.9%). Rate of advanced PVR C and D was 83%, four quadrant (total RD) 55.6%, macula detachment 91.7%, giant tear size was 90 to 180 degree and > 180 degree in 55.6% and 33.3% respectively. Single surgery attachment rate was 41.7% and final attachment after a second surgery was 86.1%. Visual outcome was CF or better in twenty-three eyes (63.9%). Recurrent RD in 58.3% was due to postoperative PVR. Gender, age, laterality, PVR grade, giant tear size, quadrants affected by RD had no impact on anatomical outcome (p> 0.05). Significantly, scleral buckle (SB) use did not reduce rate of recurrent RD and had no significant effect on anatomical outcome (p > 0.05). Conclusion: GRT RDs have a higher rate of PVR compared to more commonly encountered RRD. When treating GRT RD with advanced PVR, meticulous membrane removal should be accomplished using vital dyes to aid visualization. This will reduce recurrence of postoperative PVR. Pre-, intra- and post-operative factors, including use of a SB did not affect single surgery success. Visual improvement is limited by the occurrence of PVR.
Non-Invasive Blood Pressure Total Waveform Monitoring Using Information Extracted by an Extended Kalman Filter Algorithm from Pulsations in an Oscillatory Cuff
Authors: Hullender David , Brown Olen , Shrotriya Atul
Published: April 2023

This paper describes a novel approach designed for non-invasive, routine screening of patients for cardiovascular disorders without the complexities of using an electrocardiogram or invasive probes. Specifically, an oscillographic-view of the brachial artery blood pressure waveform, including the dicrotic notch, is extracted from information in the pressure pulsations from an ordinary blood pressure cuff. The novelty of this approach is that the total continuous shape of the waveform, not just two numbers for pressures, is generated. A computer algorithm processes the cuff pressure pulsations and provides a near real-time visual estimate of the continuous shape of the blood pressure waveform to be viewed on oscilloscopes commonly used in hospitals and medical clinics. A model-based Extended Kalman Filter (EKF) algorithm is used to process the information and identify the coefficients of a Fourier transform model for the waveform and the coefficients for an empirical model for artery stiffness. By viewing the total waveform, variations or disorders in the waveform during a series of pulse cycles can be observed and easily recognized. Simulations of two-case studies demonstrate successful convergence of the algorithm for a variety of waveform disorders including arrhythmia, variations in the shape of the dicrotic notch, changing systolic and diastolic pressure levels, and stiff arteries. Experimental verification of this proposed procedure will require invasive pressure measurements while simultaneously processing the algorithm for non-invasive waveform comparisons. Once the algorithm is verified experimentally, the end goal is to use the procedure on patients with known cardiovascular diseases in order to easily create a database of waveform disorders correlated with disorders of specific cardiovascular diseases.
Towards adaptive structuring of the lupologist’s consultation to transform the care pathway of systemic lupus erythematosus
Authors: Chiche Laurent , Thomas Guillemette , Chiche Noémie , Escoda Thomas
Published: April 2023

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, which can be clinically heterogeneous in the same patient over the disease process and has an unpredictable evolution. Although its prevalence is increasing, SLE remains a rare disease with frequent extra-articular manifestations managed by multiple specialists. Among these, the internist is a key player in the overall coordination of the care pathway. The dramatic improvement in the short-term prognosis of SLE observed over the past few decades has favoured the emergence of more chronic disease-associated morbidities, especially infectious, cardiovascular and/or related to sequelae, notably renal. Thus, every lupologist is confronted with the difficulty of having to address, in an educational, individualised but also systematic way, a certain number of key items on which the short-, medium- and long-term medical future of patients who develop SLE at a relatively young age depend. In recent years, in addition to the creation of a network of reference centres and the drafting of regularly updated national therapeutic guidelines and therapeutic education programs, international consensus about the factors to consider in SLE patients has been reached, including the definition of therapeutic objectives according to a treat-to-target (T2T) strategy. However, the translation of these new objectives/paradigms in real-life has encountered a number of difficulties. As part of a multidisciplinary team involving SLE patients, we developed practical tools in the form of CHECKLISTs addressing the problems of refractory SLE (D2T), the management of comorbidities and toxicities (BASICs), and, more recently, therapeutic de-escalation with a shared medical decision (T2U). It appears that there is an opportunity to transform the care pathway of SLE patients by allowing the implementation of these tools within adaptive structuring of the consultation, which has the advantage of defining a starting point within the care pathway as a common denominator for lupologists, regardless of their specialty or where they work.
Industrial Enterprises and Their Role in the Innovative Development of the Region
Authors: Карпов А.С.
Published: April 2023

Рассматривается роль промышленных предприятий в  инновационном развитии региона. Инновационное развитие регионов понимается как сбалансированное сочетание инициатив «сверху» (поступающих от федеральных органов власти), «снизу» (заинтересованности руководителей производственных структур во внедрении инноваций) и «извне» (со стороны инвесторов) с  учетом региональной специфики и  ограничений, присущих конкретной территории. Рассматриваются, помимо прочих, категории «умная специализация региона» и «пространственная (инновационная) стратегия». Одним из путей инновационного развития промышленности региона является компетентностный подход, который акцентирует внимание не на предприятии как таковом, а на наборе его компетенций, и кластеризация, таким образом, происходит из учета перспективных, приоритетных и подходящих для региона компетенций. Данный подход рекомендуется реализовывать поэтапно, при участии представителей органов власти, инвесторов, учебных и исследовательских учреждений и руководителей предприятий и предпринимательских ассоциаций.

The article considers the role of industrial enterprises in innovative development of the region. Innovative development of the regions is understood as a balanced combination of initiatives coming from the federal authorities, initiatives coming from the heads of production structures who are interested in the introduction of innovations and from outside investors, taking into account the regional specifics and limitations inherent in specific territory. The categories of “smart specialization of the region” and “spatial (innovation) strategy” are considered, among others. As one of the ways of innovative development of the industry of the region is a competency-based approach, which focuses not on the enterprise as such, but on a set of its competencies. Thus, clustering comes from taking into account potential, priority and suitable competencies for the region. Th is approach is recommended to be implemented in stages, with the participation of representatives of authorities, investors, educational and research institutions and heads of enterprises and business associations.
Public Joint Stock Company “RusHydro” – The Current State and Prospects of Development
Authors: Живов А.М.
Published: April 2023

Представлено исследование деятельности публичного акционерного общества «РусГидро», выявлены перспективы развития компании в  современных условиях путем анализа природы деятельности компании, структуры функционирования и  анализа финансовых показателей с  дальнейшим выявлением сильных сторон организации. Результаты исследования демонстрируют, что «РусГидро» является системообразующим и  важным элементом Единой энергетической системы России, что открывает для компании огромные перспективы развития не только технологическом отношении, но и в плане финансовой успешности, так как компания производит ресурс неограниченного спроса, требуемый не только в  каждой производственной отрасли, но и в бытовой жизни населения.

The purpose of the article is to study the activities of the Public Joint Stock Company “RusHydro” and identify the prospects for the development of the company in modern conditions by analyzing the nature of the company’s activities, the structure of functioning and financial indicators with further identification of the strengths of the organization. The results of the study will demonstrate that “RusHydro” is a backbone and important element of the Unified Energy System of Russia. This opens up huge development prospects for it both in technological progress, but also in financial success, since the company produces a resource of unlimited demand, required not only in every industrial sector, but also in the everyday life of the population.
Innovation in Business: Pros and Cons (In English)
Authors: Сахария К.Т.
Published: April 2023

Быстрый рост бизнеса привел к  формированию новой конкурентной среды с преобладанием инновационных решений, которые пытаются повысить эффективность различных процессов путем внедрения новых подходов. Статья посвящена внедрению инноваций для повышения эффективности бизнеса. Отмечается, что из-за ограничений традиционных подходов руководители предприятий должны постоянно искать новые способы внедрения инноваций. С этой целью используются историческая и описательная методологии для получения доступа и оценки эффективности инноваций в бизнесе «за» и «против».

The rapid growth of business resulted in the formation of a new competitive environment with the dominance of innovative solutions that attempt to increase the effectiveness of various processes by introducing new approaches. Hence, the article is focused on innovation implementation in bringing effectiveness into business. The article further observes that due to the limitations of traditional approaches, business executives must constantly seek out novel ways to innovate. To this end, the article employs historical and descriptive methodologies to access and evaluate the performance of innovation in business pros and cons.
Glamping Market in Russia: Formation and Prospects for Development
Authors: Сыпачева А.В.
Published: April 2023

Рассмотрена глэмпинг-индустрия в мире и в России. Изучено понятие глэмпинга и  история его возникновения, подробно описаны типы данного вида размещения. Уделено внимание вопросу сертификации глэмпингов в мировой практике и законодательному закреплению термина. Рассмотрена практика организации глэмпинг-индустрии в  других странах. Приведены статистические данные за последние несколько лет, показывающие динамику развития индустрии, проведен анализ рынка глэмпингов в России.

The article examines the glamping industry in the world and in Russia. The concept of glamping and the history of its origin are studied, and the types of this kind of placement are also described in detail. The article pays special att ention to the issue of certification of this type of placement in world practice and legislative consolidation of the term. The practice of organizing the glamping industry in other countries is considered. The author provides statistical data for the last few years showing the dynamics of the glamping industry development and the analysis of the glamping market in Russia is carried out.
Impact of Digitalization on Changes in Understanding the Human Rights System
Authors: Быкова Н.В.
Published: April 2023

Рассмотрены вопросы трансформации понимания системы прав человека в цифровую эпоху. Исследование проведено с использованием методов юридического моделирования и прогнозирования. Отмечено, что в научной среде и сфере публичного управления отсутствуют полные представления о влиянии цифровых преобразований на изменения в правозащитных механизмах и их целесообразности. Представлены вопросы понижающего и повышающего влияния цифровизации на права человека. Смоделированы изменения в понимании гражданских прав. Сделан вывод о необходимости комплексно учитывать объективные научные знания в юридическом прогнозировании, а также реализовывать меры по адаптации правозащитных систем к цифровым реалиям, чтобы пользоваться их преимуществами, нивелируя негативные воздействия.

The paper addresses the issues concerning transformation of the human rights system understanding in the digital age. The study was conducted using the methods of legal modeling and forecasting. It is noted that in the scientific community and the field of public administration, there is probably no complete understanding of the impact of digital transformations on changes in human rights mechanisms and the appropriateness of application. The paper dwells on the questions of the decreasing and increasing influence of digitalization on human rights. Changes in the understanding of civil rights are modeled. It is concluded that it is necessary to comprehensively consider objective scientific knowledge in legal forecasting, as well as to implement measures to adapt human rights systems to digital realities to enjoy their advantages, and levelling their negative impact.
Kesesuaian Habitat Peneluran dengan Wisata dan Daya Dukung Kunjungan di Kawasan Pelestarian Penyu Pantai Batu Kumbang, Kabupaten Muko-Muko, Provinsi Bengkulu
Authors: Santri Purari putra  , Imran Zulhamsyah , Sulistiono Sulistiono
Published: April 2023

The balance of ecological and economic utilization plays a real role in maintaining the stability of turtle nesting habitat on the coast. This study aims to calculate the suitability index and visitation carrying capacity (DDK) of sea turtle nesting habitat to maintain the sustainability of its population. The survey was conducted in December 2020 to January 2021 at Batu Kumbang Beach, Pulau Baru Village, Muko-Muko Regency. The analysis used was the Habitat Suitability Index (IKH), Tourism Conformity Index (IKW), and visitation carrying capacity (DDK). The Mukomuko Turtle Conservation Nature Lovers Community (KPAKPM) reported that this beach is still predominantly used as a nesting habitat for green turtles (Chelonia mydas), olive ridley sea turtles (Lepidochelys olivacea), hawksbill turtles (Eretmochelys imbricata), and leatherback turtles (Dermochelys coriacea) in 2018. At least 35 heads of various types landed and laid eggs here and further decreased in 2020 with only 17 heads. The IKH showed that about 84.06%, 75.36%, and 75.36% belonged to the highly appropriate category and were spread out at Stations 1, 2, and 3, respectively. The suitability of the coastal area is at a value of 2.0 ≤ IKW < 2.5, and is categorized as sustainable. The number of visitors allowed according to DDK is only 84 people per day. Batu Kumbang Beach needs to be managed in a balanced manner with a conservation approach and beach ecotourism to ensure the sustainability and sustainability of nesting habitats for various types of turtles.

 

Keywords: beach conservation, ecosystem, turtle nesting habitat
Correlation of Rice Production and Greenhouse Gas Emissions in North Sulawesi Province
Authors: Thomas Suli Andreas Aprilano , Damanik Mario
Published: April 2023

This study aimed to reveal correlation, calculate significance, and discover the regression equation of rice production to Green House Gas (GHG) emission in North Sulawesi Province. The data on GHG emissions from rice cultivation (Gg CO2eq) was obtained from the Ministry of Environment and Forestry of Indonesia. Data on rice production from wetland and dryland (Gg) was from the BP Statistical Review annual period of 2000-2021, both for North Sulawesi Province. Data analysis of correlation coefficient, F-test for Regression, and Simple Regression Analysis will be processed with the help application of MS Excel. The results show that the correlation between rice production and emission of rice cultivation in North Sulawesi Province is 0.53 and classified as a moderate correlation. The coefficient of determination stated that the emission of rice cultivation could be explained by about 28.6% from rice production. Therefore, rice production is statistically significant to the emission of rice cultivation with a 5% confidence level for North Sulawesi Province. Furthermore, this study found a regression equation, emission of rice cultivation is 112.67 + 0.516 times rice production.

 

Keywords: correlation coefficient, green house gas emission, rice production
Profil Fisiologis Pascapemberian Katuk Depolarisasi untuk Peningkatan Produktivitas Sapi Pedaging
Authors: Tarigan Ronald , Atabany Afton , Satrija Fadjar , Muladno Muladno , Hanif Nofriyandi , Suprayogi Agik
Published: April 2023

Katuk (Sauropus androgynus), a traditional herb that has been traditionally consumed by breastfeeding mothers to increase their milk production but still has some side effects, such as bronchiolitis obliterans and inhibition of calcium absorbtion. Removing the polar compounds in katuk leaf (depolarized katuk leaf) can eliminate those side effects without eliminating its side effect in increasing milk production and body growth in several production animals. This study was aimed to analyze the physiological status of beef cows consuming diet supplemented with depolarized katuk leaf as feed additive by measuring their hematology and blood mineral profile. Nine Brahman cross cows in the finisher stage, were grouped based on their diet: complete feed (control), complete feed plus depolarized katuk leaf powder (P1; 100 g per day), and complete feed plus depolarized katuk leaf pellet (P2; 100 g per day). Blood sample was collected after six weeks of consumption for analysis of hematological profiles including total erythrocytes, hematocrit, hemoglobin, total leukocytes, stress index (neutrophil-lymphocyte ratio); and blood mineral concentration (calcium and phosphorous). Dietary administration of depolarized katuk leaf did not have any statistically significant effect on all hematology parameters and blood mineral profiles. In conclusion, depolarized katuk leaf can be used as a growth promoter in beef cows without any negative effect on their physiological status.

 

Keywords: Hematologi, katuk depolarisasi, kesehatan, mineral, sapi pedaging
Efisiensi Alokatif Usaha Tani Paprika di Kecamatan Cisarua
Authors: Hidayanti Cika Santi , Hastuti Hastuti
Published: April 2023

Cultivation of bell peppers by farmers in Pasirlangu Village, Cisarua District, West Bandung Regency, tends to reach less optimum production, indicated by the average production per crop. The purpose of this study is to evaluate three aspects: (1) factors that affect productivity, (2) allocative efficiency, and (3) income of paprika farming in Pasirlangu Village. The Ordinary Least Squares method was used to analyze factors affecting productivity, the Marginal Product Value method to assess allocative efficiency, and the R/C ratio to calculate cultivation profits. The results showed that labor and seed inputs are inputs that have a significant effect on the productivity of agricultural businesses. In the efficiency analysis, seed input and husk charcoal are not efficient inputs, so these inputs need to be added. The income analysis shows that the paprika farming business in Pasirlangu Village is still profitable even though it is not optimal, as indicated by the ratio of profits and costs, which is > 1.

 

Keywords: bell pepper, income analysis, marginal product value, ordinary least squares, R/C ratio
Digital oscillography of proton-conductive polymer membranes
Authors:   Donetsk Institute for Physics and Engineering named after A. A. Galkin, Prokhorov Igor Yu.
Published: April 2023

Polyvinyl alcohol-based cast membranes have promising application in creating commonly available fuel cells and fuel synthesizers, as well as inexpensive water sources and microelectromechanical systems. In order to control the properties of such membranes a deep understanding of the charge transfer mechanisms and their relationship with the structure formed at a certain composition and manufacturing technology is required. A method for studying the structure of the proton-conductive polymer membranes using digital oscillography of ion currents excited by the low-frequency rectangular pulses with the amplitudes below the threshold voltage of the ionic conductivity in a dehydrated membrane, and for the analysis of the resulting ion current pulses (spikes) in the frames of the model of a proton pump acting in each layer of the membrane is proposed in this paper. Fast Fourier transform of these oscillograms reveals from 2 to 4 branches or spike sequences corresponding to the phases with different ionic conductivity and makes it possible to determine the thicknesses of both high-conductivity phase layers (7–30 µm) and low-conductivity phase interlayers (1–7 µm) formed in the process of polymerization. The reason of spike merging into bursts is described in terms of successively induced increase in the excited proton density over a threshold value in highly conductive layers. The resonance observed in dry proton membranes at the frequencies of about 2.2 to 3.0 kHz is interpreted as the burst merge point with the further increase in impedance due to proton lagging and respective decrease in the effective thickness of active layers. The effective charge carrier concentrations (as small as 1012 to 1013 cm−3) and the velocity (from 5 to 18 cm/s for the highly conductive phases which turned out to be much higher than those observed in solutions) are estimated. The asymmetry of the cast membranes, which becomes apparent at low frequencies and causes the generation of a direct ion current in response to excitation by a purely alternating current, is studied. It is found that the apparent conductivity determining contribution to the total ohmic resistance is made by a thin interlayer with a very low ion velocity, presumably surface layer, rather than the main layers. The conclusion on the optimization of the production technology and the composition of the proton membranes for various applications is made.
The results of liver transplantation performed in a single center due to hepatocellular carcinoma
Authors: ASLAN Serdar , YAZAR Şerafettin , KARGI Ahmet , KURNAZ Eray , ŞAHİN Dilek , PEKER Kemal , ASTARCİOGLU Ibrahim , POLAT Kamil
Published: April 2023

Objective: Hepatocellular cancer (HCC) is the most common malignancy of the hepatobiliary system. There are significant differences in the global spread of HCC. It is the major cause of death in patients with cirrhosis. Its molecular pathogenesis is highly complex and heterogeneous. Major risk factors for the development of HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection and alcohol-related liver cirrhosis. Hepatocellular cancer is rarely seen in the first 4 decades of life, except in communities where HBV infection is hyperendemic.

Method: The study was conducted by retrospectively scanning the files of 204 patients diagnosed with HCC who applied to Organ Transplantation Center between 21.09.2014 and 13.04.2019. Patients were transplanted liver by being classified according to Milan criteria, San Francisco [University of California San Francisco (UCSF)] criteria, and Barcelona Clinic Liver Cancer (BCLC) criteria.

Result: The median age of the patients was 58.03 (range 31 to 72). 170 of the patients were men and 34 of them were female. Liver transplantation was performed from cadaveric donors to 31 patients and from living donors to 173 patients. There is a significant relationship between the life span of the patients and their gender. Female patients have a longer life expectancy [t (202) = 2,963, p =, 003]. A significant relationship was found between life expectancy and surgical classification [F (3) = 3,008, (p =, 031)].

Conclusion: In patients diagnosed with HCC and undergoing liver transplantation; the gender being female and the classification method before transplantation affect life expectancy.
Niepewność zatrudnienia wśród pracowników na przykładzie banków
Authors: Kaźmierczyk Jerzy
Published: April 2023

Głównym celem monografii jest identyfikacja i pomiar powiązań niepewności zatrudnienia z wybranymi aspektami pracy (stresem, zaangażowaniem organizacyjnym i subiektywnie postrzeganą efektywnością pracy, z uwzględnieniem wpływu takich mediatorów organizacyjnych jak zaufanie i relacje interpersonalne oraz wpływu postrzeganej zatrudnialności i kontroli nad pracą). Przeprowadzono pogłębioną analizę literatury przedmiotu, opartą na blisko 700 pozycjach dotyczących niepewności zatrudnienia na gruncie ekonomii i finansów. Badania autorskie pozwoliły zapełnić część luk, zarówno tych dotyczących technik i metod badawczych, jak i samego meritum niepewności zatrudnienia. Badanie empiryczne przeprowadzono wśród pracowników polskich banków na dużej próbie badawczej ponad 2400 osób, co jest istotne ze względu na brak do tej pory takich badań w Europie Środkowej i Wschodniej. To pierwsza w Polsce praca całościowo traktująca zagadnienie niepewności zatrudnienia (przyczyny, skutki, metody pomiaru, subiektywna niepewność zatrudnienia, ilościowa i jakościowa niepewność zatrudnienia). W warstwie empirycznej bazuje na bankach, jednak zarówno rozważania teoretyczne, jak i wnioski w dużym stopniu mają charakter uniwersalny i mogą zostać wykorzystane w odniesieniu do niepewności zatrudnienia w innych sektorach gospodarki.