bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustained attention, not procedural learning, is a predictor of reading, language and arithmetic skills in children
Authors: West Gillian , Shanks David , Hulme Charles
Published: September 2018

This is an original manuscript of an article published by Taylor & Francis in Scientific Studies of Reading (SSR) on 14th April, 2020, available online: http://www.tandfonline.com/[Article DOI: http://dx.doi.org/10.1080/10888438.2020.1750618].The procedural deficit hypothesis claims that impaired procedural learning is a causal risk factor for developmental dyslexia and developmental language disorder. We investigated the relationships between measures of basic cognitive processes (declarative learning, procedural learning and attention) and measures of attainment (reading, grammar and arithmetic) in a large sample of 7- and 8-year-old children. A latent variable path model showed that verbal declarative memory skills predicted attainment but were not significantly related to attention. Procedural learning was only weakly related to measures of attainment and attention assessed during the procedural learning task accounted entirely for its relationship with measures of attainment. Our results challenge the procedural deficit hypothesis of reading and language disorders, but suggest that attentional skills (rather than procedural learning ability per se) may be an important predictor of reading, arithmetic and grammatical skills.
A Comparative Study of Exclusive Breastfeeding Practices Among Working and Non-Working Women in Bharatpur-Tandi, Chitwan, Nepal
Authors: Duwadi Sabina , Upadhyay Hari Prasad
Published: September 2018

Background: Breastfeeding has been accepted as the most vital intervention for reducing infant mortality, ensuring optimal growth and development of children. Twenty-two percent of newborn deaths can be prevented through breastfeeding in the first hour of birth.Objective: The objective is to find the proportion of exclusive breastfeeding practices among working and non-working women and significant factors associated with exclusive breastfeeding practices. Exclusive breastfeeding means a baby receives only breast milk without any additional food or drinks, including water until 6 months of age.Materials and Methods: Semi-structured schedule was adopted to take the information from the respondents. The sample size of the study was 140 of which 70 working and 70 non-working women were selected purposively. Results: The percentage of exclusive breastfeeding practices among working women was 67.10% and 81.4% among non-working women. More than 90% of the women knew the importance of breastfeeding. Similarly, 68.9% of working and 67.7 % of the non-working women had initiated breastfeeding within one hour of birth. Type of family, number of children, working hour were statistically significant to exclusive breastfeeding practices.Conclusion: Exclusive breastfeeding practices were quite higher among non-working women compared to working women. In order to improve breastfeeding practices the concerned authority should formulate the provision of child health care center at working places.Nepalese Journal of Statistics, Vol. 2, 1-10
A Probabilistic Approach for Assessment of Future Drought in Bagmati River Basin, Nepal
Authors: Shrestha Rajendra Man , Sthapit Azaya Bikram , Shrestha Srijan Lal
Published: September 2018

Background: The Bagmati River is the rain-fed river in the basin of Nepal. The climate change in rainfall patterns may lead to drought or flashflood in this basin. Drought is a silent and pervasive hazard due to the deficit of water availability. It may have adverse impact on society leading to impact on environment, culture, political and other functions of the region.Objective: This study aims to assess the future drought in the Bagmati River Basin, Nepal.Materials and Methods: Providing Regional Climates for Impact Studies precipitation data was obtained from Department of Hydrology and Meteorology, Kathmandu. The Generalized Extreme Distribution was fitted to respective total precipitations in 3 time-scales using EasyFit software. Standardized Precipitation Index (SPI) method was used to derive SPI for winter drought, SPI for summer drought and SPI for long-term (annual) drought.Results: The results of data analysis showed that winter moderate drought episodes may occur in years 2035, 2042, 2048, 2049, 2051 and 2053. Likewise, summer severe drought episode may occur in 2046. The year 2046 also indicated long-term extreme drought. Moreover, 2030, 2031, 2035, 3040 and 2053 may be long-term moderate drought episodes years in future.Conclusion: There may be winter moderate drought, summer severe drought and a long-term extreme as well as moderate drought during the future period 2030-2060.Nepalese Journal of Statistics, Vol. 2, 75-88
Impact of performance appraisal reactions on affective organizational commitment and work performance
Authors: Husain Kamil
Published: September 2018

The objective of the study is to examine the relationship between performance appraisal reactions and employeesâ€™ outcome in terms of affective organizational commitment and work performance in Pakistanâ€™s 5 largest banks, which is situated at federal capital city, Islamabad, by using a data of 101 banking employees. The results of the survey show that performance appraisal reaction has a positive impact on organizational commitment, while it has a significant impact on work performance only for those employees whom have been receiving a high level of perceived regular feedback. This positivity describes the importance of performance appraisal reactions in high level of work performance, which was mediated by regular feedback. The results suggest that formal performance appraisal cannot compensate for low levels of regular feedback. The results derive substantial evidence of work performance by organizational commitment and performance appraisal in banking sector.
Relationship between Financial Knowledge and Spending Habits among Faculty of Managementâ€™s Staff
Authors: Binti Azmi Nor Fazleena , Ramakrishnan Suresh
Published: September 2018

Spending habits in the most desirable way is one of the factors that can lead to financial satisfaction. Therefore, financial satisfaction depends on the ability of people to manage and take control of their personal finance in order to improve their financial decision making and financial status. This study was conducted to identify the level of spending habits among Management Faculty staff at Universiti Teknologi Malaysia. This study also conducted to investigate the level of personal financial knowledge adapted by staff and lastly to determine the relationship between financial knowledge and spending habits among Management Faculty staff. The total of 97 questionnaires were distributed and completed by the staff. Data was analyzed by using descriptive, Pearson Correlation and Multiple Regression that include in Statistical Package for Social Science (SPSS). The results firstly revealed that the higher level of financial knowledge is the factors that influence the most desirable financial behavior in spending habits among staff. Secondly, the staff perceived that the financial knowledge can be enhanced through financial education in order to improve their financial planning. Finally, the result indicates that financial knowledge have positive relationship with spending habits.
Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women
Authors: Khadka Bikram , Tiwari Mohan Lal , Gautam Ravi , Timalsina Binod , Pathak Nandu Prasad , Kharel Krishna , Sharma Shanta , Acharya Dilaram
Published: September 2018

Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal. 

Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20.

Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01).

Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.
Effectiveness of Herbal Mouthwash among Visually Impaired Residential School Students
Authors: Dahal Sirjana , Shrestha Ashish , Bhagat Tarakant
Published: September 2018

Introduction: Visually impaired patients are unable to visualize the plaque on tooth surfaces resulting in inadequate plaque removal and therefore the progression of dental caries and inflammatory disease of the periodontium. The objective of the study was to assess the effectiveness of herbal mouth wash in reduction of plaque and gingivitis among visually impaired children.

Methods: Randomized controlled clinical trial was conducted with parallel groups study, comprising 6 to 20 year old visually impaired children, 20 in each group (herbal mouth wash or chlorhexidine mouthwash or placebo mouthwash). Plaque and gingival index were recorded at baseline and at the end of the study. Children were asked to use the mouth wash twice daily for two weeks. Analysis was done using Chi-square test for categorical data and Mann-Whitney U test/independent t-test and one way analysis of variance/Kruskal-wallis H test for quantitative data. The level of significance was set at P<0.05.

Results: Participants showed fair oral hygiene (mean plaque scores of 1.14±0.53) and moderate gingivitis (mean gingival scores of 1.12±0.45) with no significant difference between three groups (P=0.47 and 0.84, respectively). Significant reduction of plaque and gingivitis was seen at follow-up with no significant difference between herbal and chlorhexidine mouthwash. However, significant difference was found between placebo and herbal/chlorhexidine mouthwash.

Conclusions: Herbal mouthwash showed significant effect on reducing plaque formation and gingivitis in visually impaired students. The effectiveness of herbal mouthwash was analogous to the gold standard chlorhexidine.
Male Breast Cancer: A Rare Entity
Authors: Gautam Swotantra , Joshi Brikha Raj , Adhikary Shailesh , Regmi Sudeep , Pradhan Anju
Published: September 2018

Male breast carcinoma is a rare malignancy (<1% of all breast carcinomas, 0.2% of all male malignancies). Its common histopathological type is infiltrating carcinoma, not otherwise specified. Three male patients aged 56 (stage –IIIB), 64 (T4bN0M0) and 78 (T2N0MO) years presented with a breast lump within a year. Their hematological and biochemical parameters were within normal limits. Two of them had palpable regional lymph nodes. Male breast carcinoma occurs in older males as in our cases. Two cases showed infiltrating ductal carcinoma, not otherwise specified on histopathological evaluation, and one showed special type with apocrine differentiation. Their two-year follow-up was uneventful after modified radical mastectomy and chemotherapy. Male breast carcinoma is associated with risk factors different from and overlapping with female breast carcinoma. Male breast carcinoma differs from female breast carcinoma on clinical presentation, biological behaviour and prognosis.
Assessment of the Attitude and Knowledge of the Principles and Practices of Orthodontic Treatment Among the Non-orthodontic Specialists and General Practitioner Dentists
Authors: Kapoor Deepika , Bhatia Sandeep , Garg Deepanshu
Published: September 2018

Introduction: General practitioner dentists and non-orthodontic specialties ought to have the knowledge of the basic principles and practices of orthodontics in order to educate the patients, diagnose their problems correctly and for proper referral. The objective of the present study is to assess the attitude and knowledge of the general practitioner dentists and non-orthodontic specialists towards the basic principles and practices of orthodontics.

Methods: This study was performed by presenting a closed questionnaire to a total of 78 participants out of which 46 were general practitioners and 32 were non-orthodontic specialists. A questionnaire consisting of a total of 21 questions was distributed and each question was allocated 0.5 marks for correct response whereas no deduction for wrong answer.

Results: In this present study, the total mean score of the evaluation of the questionnaire came out for general practitioner dentist and the non-orthodontic dental specialists was 13.92 and 16.69 respectively. The present study showed a statistically highly significant knowledge and attitude difference between Group A and Group B ( P<0.001).

Conclusions: This study shows a need for a increased clinically oriented education in the undergraduate courses and a multi-disciplinary inter department seminar presentations and forums set up for the post graduation courses for them to understand the scope of each other’s specialties.
An Audit of An Intensive Care Unit of A Tertiary Care Hospital
Authors: Acharya Subash Prasad , Bhattarai Adheesh , Bhattarai Binita
Published: September 2018

Introduction: The patients with the most severe and life threatening illnesses requiring constant monitoring and support are admitted in the intensive care unit. Tribhuvan University Teaching Hospital is the oldest and tertiary referral center hospital in the country with eleven-bedded level III mixed medical surgical ICU. This audit was performed to study the profile of critically ill patients under different headings like diagnosis at admission, primary specialty, outcome of the patients, etc.

Methods: A descriptive cross-sectional study was designed and all patients admitted to the intensive care unit of our center between 13 April 2017 and 13 April 2018 (1st Baisakh 2074 to 30th Chaitra 2074) were selected for this study.

Results: A total of 813 patients were admitted in TUTH ICU over a period of one year (2074 B.S.) with male patients being more common. Neurosurgical cases were most common at 199 (24.48 %), followed by respiratory cases at 149 (18.32%) and so on. The overall mortality was 246 (32.8%). The overall surgical cases were more common than medical cases with better outcomes.

Conclusions: This audit presents the profile of patients admitted in a tertiary level hospital in Nepal, their indications and mortality. The most common patients being admitted were Neurosurgical patients and the mortality was significantly higher compared to ICUs in developed countries.
Different Sensor Systems for the Application of Variable Rate Technology in Permanent Crops
Authors: Petrović Davor , Barač Željko
Published: September 2018

The paper presents a review of different sensory systems for trees’ characterization and detection in permanent crops and the detection of plant health status in crop
conditions for the purpose of applying the variable application rate. The use of new technologies enables the use of variable inputs in production with the aim of increasing the
economic profit and reducing the negative impact on the environment. World trends increasingly emphasize the use of various sensor systems to achieve precision agriculture
and apply the following: ultrasonic sensors for the detection of permanent crops; LIDAR (optical) sensors for treetop detection and characterization; infrared sensors with similar
characteristics of optical sensors, but with very low cost prices and N - sensors for variable nitric fertilization. The daily development of sensor systems applied in agricultural
production improves the performance and quality of the machines they are installed on. With a more intensive use of sensors in agricultural mechanization, their price becomes
more acceptable for widespread use by achieving high quality work with respect to the ecological principles of sustainable production.
Application of Thermoelectric Modules as Renewable Energy Sources
Authors: Šumiga Ivan , Kondić Živko
Published: September 2018

Thermoelectric modules are used for heating or cooling if an electric current flows through them. If one side of such a module is heated and the other side is cooled, the
outputs show a potential difference that creates the current flow through an enclosed circuit. The paper describes briefly the physical basis of the operation of semiconductor
thermoelectric modules and their application for generating electricity as thermoelectric generators. The experimental measurements were made with different available modules
of thermoelectric generators. The analysis of obtained results has provided the conclusions about the possibility of their application as sources of electricity. Although the efficiency
of thermoelectric modules is still quite low, the latest research reveals the possibility of the use of materials that make modules more efficient. Considering the fact that they do not
contain moving parts, they are characterized by reliable, long-lasting work and simple operation and maintenance.
Color Perception
of the Observer with the Manifestation of the Chromatic Effect of Crispening
Authors: Hajdek Krunoslav , Hajdek Martina
Published: September 2018

This research presents the results of the appearance of chromatic effect of crispening on a designer solution in which the primary stimuli are made in the purple color
with the values of 55% RTV and 65% RTV and backgrounds are made in the green-blue color, and their variations are designed in the values of 25% RTV, 50% RTV, 75% RTV
and 100% RTV that are placed around the primary stimuli. The test subjects (n=10) that took part in the research had the task to equalize the test primary stimuli with the referential
stimuli on a computer screen with the help of the technique of simultaneous binocular harmonization. The strength of the crispening effect was defined and shown in the CIEDE00
system. The conclusion of the conducted tests indicates that the intensity of crispening was stronger on the test primary stimuli 65% RTV, where the differences in the perception
of color were more significant.
Factors affecting labour productivity of construction worker on construction site: A case of Hanoi
Authors: Tam Nguyen Van , Huong Nguyen Lien , Ngoc Nguyen Bao
Published: September 2018

Labour productivity of Vietnamese economy in general and of Vietnamese construction industry in particular is low in comparison with other countries. Boosting labour productivity is becoming an urgency and is attracting much attention from both domestic and foreign researchers. This paper focuses on a series of factors affecting labour productivity on construction site in Hanoi. The research aims to evaluate and rate the extent of impact of each factor to labour productivity. By referring to the outcomes of this study, Vietnamese construction contractors will be able to come up with workable solutions which will contribute towards a better performance of construction workers. On that basis, the productivity of construction firms and national economy will be improved correspondingly.

Keywords: productivity; labour productivity; factors affecting; construction worker.
Quality of Higher Education and Current Researches in This Area
Authors: Wubbels Teo , Kurbatov Sergiy
Published: September 2018

In his exclusive interview for our journal the President of the European Educational Research Association (EERA), Professor of Education at Utrecht University Theo Wubbels told about his professional development as an expert in the area of educational researches. He analyzed the process of establishing and further development of the internal quality assurance system at Utrecht University, which helps this university to be a leader in European and global academic space. For example, Professor Wubbels specially stressed the point, that system of quality assurance in higher education could not be reduced only to the formal mechanisms of assessment, but need to include the possibilities for professional development and intensive dialogue between teachers and students. Theo Wubbles discussed the main activities of the European Educational Research Association (EERA) and the possibilities for researchers, which membership in this association provides. He also shared his impressions from cooperation with Ukrainian colleagues.
The Philosophy of Kazimierz Twardowski: History and modern interpretation
Authors: Honcharenko Olha Anatoliivna
Published: September 2018

The program of the Symposium «The Philosophy of Kazimierz Twardowski: History and modern interpretation» dedicated to 150th anniversary of Polish philosopher and teacher Kazimierz Twardowski’s birth has been highlighted. The Symposium was organized by K. Twardowski Philosophical Society of Lviv and the Institute of Philosophy of the University of Warsaw with the support of the Center for Urban History of East Central Europe.

The reports of participants have been reviewed and the events took place within the Symposium have been described.
Key Competencies in Transnational Educational Space: the Definition and Implementation
Authors: Gorbunova Lyudmyla
Published: September 2018

The article deals with the most important factors which shape challenges for educational policy and directions of its reformation in transnational educational space. In context of global society formation educational policies of developed countries demonstrates experiences of development and implementation of transversal (transferable, transcultural) competencies as key competencies of the 21st century in order to generate collective nous, peace, social justice and sustainable economic development. As one of the main goals of key competencies development considered promotion lifelong learning; It emphasizes the need for situational, contextualize, projective teaching and constructivist approaches. Particular attention is paid to analysis of key competencies in the trans-European educational space, of transferable competencies as US educational strategy and transversal competencies as the strategies proposed by UNESCO.
A note on hyperbolic quaternions
Authors: ARDA KÖSAL İşıl
Published: September 2018

In this work, we introduce hyperbolic quaternions and their algebraic properties. Moreover, we express Euler's and De Moivre's formulas for hyperbolic quaternions.
Existence and uniqueness of an inverse problem for a second order hyperbolic equation
Authors: TEKİN İbrahim
Published: September 2018

In this paper, an initial boundary value problem for a second order hyperbolic equation is considered. Giving an additional condition, a time-dependent coefficient multiplying a linear term is determined and existence and uniqueness theorem for small times is proved. The finite difference method is proposed for solving the inverse problem numerically.
Pengaruh Kinerja Dan Kepedulian Manajemen Bank Pembangunan Daerah Di Indonesia Terhadap Porsi Penyaluran Kredit Pengembangan Sektor UMKM
Authors: Soerip S. Riauwanto
Published: September 2018

This study investigates the effect of performance management and care of BPD in Indonesia against the share of SME sector development lending.The loan portfolio BPD in Indonesia is dominated employee loans (consumer) compared with the productive sectors especially the MSME sector.The inequality shows the composition distribution disitermediari very sharp.Though SME sector contribute greatly to the economy of Indonesia.But the “concern” BPD in Indonesia management is less interested in developing SME loans larger portion of consumer credit (employees).This study uses secondary data sources from Financial Statements 26 BPD in Indonesia period 2005-2009 for which data are derived from the website of Bank Indonesia.Cross-section data and time series of data obtained are arranged into panels totaling 130 sets of data.The data of this research is the dependent variable PK (MSME sector credit portion), while the independent variables consist of CAR, NPL, EQI, ROA, LIQRR, LDR, IRISK, SIZE and SHM.Data management factors described by the factor of “concern” managers and owners (EQI and SHM).The model was tested using Hausman equation to obtain the most appropriate model.The results using fixed effects approach to data processing.Methods of data using multiple regression analysis (multiple regression model), while the data processing using statistical program eviews 6. The study found that the factors “concern” the development of the SME sector is still weak, because the portions are relatively much smaller when compared to consumer credit.In addition to a weak level of concern, caring influence too weak manager and owner of the credit portion of the development of SMEs.This is due to liquid assets tend to be directed and invested in the reserve requerment and not optimized for using the development of SMEs.Another finding is that the overall performance of BPD has no effect on the development of SME lending portion, except NPL factors and SIZE bank.NPL showed a negative effect, while SIZE positive effect on bank lending portion of the SME sector development. Thus, this study found and concluded that the performance of BPD in Indonesia in managing assets - liability to the development of the SME sector is not optimal and efficient.The portion of the SME sector has not made backbound loan portfolio, although a major contribution to the Indonesian economy.Inequality composition of the loan portfolio between consumptive portion and the SME sector credit shows that there has been disintermediari on bank performance.Therefore, profits or revenues (achievement) is now obtained the credit market has yet to show real potential, because lounable support fund owned by the BPD in Indonesia is still very large.
Pengaruh Motivasi Kerja Terhadap Kinerja Pegawai Kantor Sekretariat Daerah Kabupaten Gunungkidul
Authors: Sutrischastini Ary , Riyanto Agus
Published: September 2018

This paper will discuss the effect of work motivation (incentives, motives and expectations) on the performance of the staff of the Regional Secretariat Gunungkidul. The purpose of this paper is: 1) Determine the effect of incentives on the performance of the staff of the Regional Secretariat Gunungkidul, 2) Determine the effect of motive on the performance of the staff of the Regional Secretariat Gunungkidul, 3) To know the effect of expectations on the performance of the staff of the Regional Secretariat Gunungkidul, 4)To know the effect of incentives, motives and expectations on the performance of the staff of the Regional Secretariat Gunungkidul.Research sites in the Regional Secretariat Gunungkidul and the population is 162entire employee in the Regional Secretariat Gunungkidul. Samples amounted to 116 respondents taken with simple random probability sampling method. Data were analyzed using multiple linear regression. Results obtained: (1) incentives positive and significant effect on the performance of, (2) motif positive and significant effect on the performance of, (3) expectations positive and significant impact on the performance of , and (4) incentives, motives and expectations of positive and significant impact on the performance of the staff of the Regional Secretariat Gunungkidul.
Pengembangan Marketing Knowledge Ditengah Perbedaan Perspektif Akademisi-Praktisi
Authors: Wibowo Amin
Published: September 2018

Knowledge is created and learned by academicians for the purpose of further theory development. Academician’role in disseminating knowldege is very important. To reach a convergent understanding both theory and practice, it’s a need of flexibility between methodology and sources of data so that it stimulates actionable insight.One of the problems between theory and practice differencesis customers focus.For practicians customer focus raised three foundamentals questions: can the knowledge phylosophy reduce cost?. Can the knowledge phylosophy increse sales?, and can the knowledge phylosophy increase the profit?. This paper discuss the development of marketing knowledge based on the marketing practice to bridge the gap between academicians and practicians. Issues being discussed in this paper are the meaning of marketing knowledge from practician perspective, the theory of marketing in practician’s world, actionable research as the bridge of knowledge development, and the difference perspective between academician and parctician.
Pengaruh Kepemimpinan, Lingkungan Kerja Dan Jenjang Karyawan Terhadap Kinerja Pegawai
Authors: Nurwahyudi Muhammad Robi
Published: September 2018

The influence of leadership, work environment and the level of employees of the performance of employees at the Pos Office Agent UGMYogyakarta and the main objective of this research is to test the influence of motivation, leadership, communication, and rewards together and in partial of the performance on the data collected from 30 respondents.Together factors leadership, work environment, and the level of employees have had a positive impact and significant of the performance of employees which evidenced by constant value 3.527 and f-hitung = 3,001 & gt; f-tabel = 2,780. Leadership have had a positive impact and significant of the performance of employees which evidenced by the magnitude of the regression coefficient 0,401 and t-statistik = 2,317 & gt; t-tabel = 1,725. Work environment have had a positive impact and significant of the performance of employees which evidenced by the magnitude of the regression coefficient 0,411 and t-statistik = 2,249 & gt; t-tabel =1,725. The level of work have had a positive impact and significant of the performance of employees the Pos Office Agent UGMas evidenced by the magnitude of the regression coefficient 0,411 and t-statistik = 0,2304 & gt; t-tabel =1,725.
Strategi Obyek Wisata Di Gunung Kidul
Authors: Zuraida Lukia , Handayani Marliana , Novitasari Dwi
Published: September 2018

Gunung Kidul District is one of areas in Yogyakarta Special Region in which has potentialities of special interests of natural tourist destinations. It has about 58 caves, 69 beaches, and many other natural tourist destinations. Most of them are Karst as the main potential of natural destinations. Regarding with the special interests on tourism, Gunung Kidul District has given contribution to the Yogyakarta Regional Revenue on tourism it’s about 4,5 billion in 2012. It means that there is increasing of the revenues about 133 % from 2011, with the regional revenue is about 1,7 billion. Based on the contributions of regional revenues on tourism field, and the significant increase of the tourists, especially in Pindul Cave and Indrayanti Beach during last five years, it is necessary to have research on Marketing Strategies of Pindul cave Tourist Destinations and Indrayanti Beach. The aim of the research is to analyze the Marketing strategy of Pindul cave and Indrayanti Beach. Another purpose to discover factors weather internal or external factors give influences to the Marketing strategy of Pindul Cave and Indrayanti Beach. To get comprehensive data, this research used several data collection methods, participary observations, and in–depth interview with visitors, agencies, communities, government, and local people. Based on the descriptive analyze of the 30 interviewers about Pindul Cave and Indrayanti Beach , most of them explained that marketing of Pindul Cave and Indrayanti Beach are quite good. The analyze proved that the agencies and the marketing strategies of Pindul Cave and Indrayanti Beach are at the first (I) quadrant (the Growth), in which they have opportunities and strengths to be developed, with the differencies of their opportunities and strength .
Analisis Positioning Dan Brand Awareness Terhadap Keputusan Pembelian Handphone Blackberry Pada Mahasiswa Fakultas Ekonomi Ugm
Authors: Zuraida Lukia , Novitasari Dwi
Published: September 2018

This research analyzed positioning and brand awareness on decision to purchase Blackberry handphone. The research done in 2013 using 100 students of economic faculties, UGM. The analytical method used was multiple regression. The results showed that a significant differences between positioning with purchasing decisions as indicated by the significance value below 0.005 and brand awareness with purchasing decisions have significance value below 0.000. This suggests that the higher positioning and brand awareness will be increased purchasing decisions.
Kepuasan Masyarakat Terhadap Pelayanan Polisi Sektor Bawang Kabupaten Banjarnegara
Authors: Sumino Sumino , Sutrischastini Ary
Published: September 2018

This research objectives to understand how big citizen’s satisfaction on Bhabinkamtibnas’ service officers in build Kamtibnas in Polsek Bawang Banjarnegara area. Respondents taken as many as 100 people as samples by the method Accidental sampling. Interviews and surveys was the method that used in data collection. Anlaysis method used on this research was SERVQUAL method.This research have five dimension SERVQUAL, there are tangible, Reliable, Responsiveness, Assurance, dan empathy. The results are overall of each attributes dimensions SERVQUAL still negative and has an average gap by -0.36. This shows that Bhabinkamtibnas’ service officers still didn’t meet the citizen satisfactory. Despite the value of gap very small (under 1), this indicates that Bhabinkamtibnas’ service officers still need to improve its quality to reach the ideal services.
A study of neutron emission spectra and angular distribution of neutron from (p,n) reaction on some targets of heavy elements
Authors: Nguyen Thu Thi Ai
Published: September 2018

For the design of ADS (Accelerator Driven System), it is important to study neutron spectra and details of nuclear reactions induced by neutrons. Furthermore, neutron energy and angular distribution data are important for a correct simulation of the propagation of particles inside a spallation target and the geometrical distribution of the outgoing neutron flux. Many experimental results are available for thin targets and massive targets additional studies of neutron spectra and neutron production were investigated to design target for ADS with incident proton energies up to 3 GeV. In our study, the angular distribution and the neutron energy spectra are reported for the (p,n) reaction on target nuclei such as Pb, U, W with energy from 50 MeV to 350 MeV calculated with database of JENDL-HE 2007. We obtain a set of data about the angular distribution and energy spectra of produced neutrons on some heavy targets with energy ranges as stated above. From the results of neutron spectra, the paper also gives many comments to recommend a choice of materials for target and energies for accelerating proton beam . From the angle distribution of neutrons generated in (p, n) reactions on the different targets with the different energies of proton, the solutions to arrange the reflection bars in reactor proposed. A comparison is also made to improve the reliability for calculation of the paper.
Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis
Authors: Gong Xianling , Sun Ruibo , Gao Zhuowei , Han Weili , Liu Yawei , Zhao Liang , Jing Linlin , Yao Xueqing , Sun Xuegang
Published: September 2018

Macropinocytosis is a highly conserved endocytic process which characterizes the engulfment of extracellular fluid and its contents into cells via large, heterogeneous vacuoles known as macropinosomes. Tubeimoside-1 (TBM1) is a low toxic triterpenoid saponin extracted from a traditional Chinese herb Bolbostemma paniculatum (Maxim.). TBM1 stimulates a quick accumulation of numerous phase-lucent cytoplasmic vacuoles in multiple colorectal cancer (CRC) cell lines. These vacuoles can be termed as macropinosomes that efficiently engulf lucifer yellow. These vesicles are not overlaps with endocytic organelle tracers, such as ERTracker, LysoTracker and mitoTracker. These vacuoles induced by TBM1 partially incorporate into lysosomes. Transmission electron microscope indicates membrane ruffling to form lamellipodia. Protrusions collapse onto and then fuse back with the plasma membrane to generate these large endocytic vacuoles. Notably, TBM1 efficiently trafficks dextrans into heterotopic xenografts in vivo, thus provide consolidated evidence that the vacuolization can be mainly defined as macropinocytosis. TBM1 downregulates cell viability and increases PI-positive, but not highlighted Hoechst 33342-positive cells. TBM1 induced cell death can be ascribed as methuosis by hyperstimulation of macropinocytosis which can be compromised by amiloride derivative 5-(Nethyl-N-isopropyl). Light chain 3 II is recruited to these vesicles to stimulate macropinocytosis. The cell death and vacuoles can be significantly neutralized by chloroquine, but can not be the inhibited by 3-methyladenine. TBM1 can coordinate with 5-FU to exert toxicity reducing and efficacy enhancing effects in vivo by increasing the uptake of the latter without hepatic injury. In conclusion, TBM1 effectively induces in vitro and in vivo macropinocytosis which can traffick small molecules into CRC cells. It is an attractive drug transporter and can be harnessed as a chemotherapeutic synergist with translational potential.
Identification and Characterization of the Glutathione Peroxidase (GPX) Gene Family in Watermelon and Its Expression under Various Abiotic Stresses
Authors: Zhou Yong , Li Jingwen , Wang Junhong , Yang Wenting , Yang Youxin
Published: September 2018

Plant glutathione peroxidase (GPX) is an important antioxidant enzyme to maintain H2O2 homeostasis and regulate plant response to abiotic stress. In this paper, we present the first report of a genome-wide identification of GPX genes in watermelon. A total of six genes (ClGPX1–ClGPX6) were identified, which were unevenly located on four chromosomes of the watermelon genome. Based on phylogenetic analysis, the GPX genes of Arabidopsis, rice, cucumber, and sorghum were classified into four groups. Through analyzing the promoter regions of ClGPX genes, many development-, stress-, and hormone-responsive cis-acting regulatory elements were also identified. Expression pattern analysis by qRT-PCR indicated that all ClGPX genes were actively expressed in flowers and fruits, and exhibited relatively lower expression in other tissues, particularly roots and stems. In addition, the expression of ClGPX genes was significantly induced by salt, drought, and cold stresses, as well as abscisic acid (ABA) treatment at different time points, suggesting that they may be involved in response to abiotic stress and ABA. Taken together, our findings demonstrated that ClGPX genes might function in watermelon development, especially in flower and fruit tissue, as well as in response to abiotic stress and hormones.
Sources of Airborne Endotoxins in Ambient Air and Exposure of Nearby Communities—A Review
Authors: Rolph Catherine A. , Gwyther Ceri L. , Tyrrel Sean F. , Nasir Zaheer A. , Drew Gillian H. , Jackson Simon K. , Khera Shagun , Hayes Enda T. , Williams Ben , Bennett Allan , Collins Samuel , Walsh Kerry , Kinnersley Rob , Gladding Toni L.
Published: September 2018

Endotoxin is a bioaerosol component that is known to cause respiratory effects in exposed populations. To date, most research focused on occupational exposure, whilst much less is known about the impact of emissions from industrial operations on downwind endotoxin concentrations. A review of the literature was undertaken, identifying studies that reported endotoxin concentrations in both ambient environments and around sources with high endotoxin emissions. Ambient endotoxin concentrations in both rural and urban areas are generally below 10 endotoxin units (EU) m−3; however, around significant sources such as compost facilities, farms, and wastewater treatment plants, endotoxin concentrations regularly exceeded 100 EU m−3. However, this is affected by a range of factors including sampling approach, equipment, and duration. Reported downwind measurements of endotoxin demonstrate that endotoxin concentrations can remain above upwind concentrations. The evaluation of reported data is complicated due to a wide range of different parameters including sampling approaches, temperature, and site activity, demonstrating the need for a standardised methodology and improved guidance. Thorough characterisation of ambient endotoxin levels and modelling of endotoxin from pollution sources is needed to help inform future policy and support a robust health-based risk assessment process.
Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process
Authors: Goldrick Stephen , Lovett David , Montague Gary , Lennox Barry
Published: September 2018

Raman spectroscopy is a novel tool used in the on-line monitoring and control of bioprocesses, offering both quantitative and qualitative determination of key process variables through spectroscopic analysis. However, the wide-spread application of Raman spectroscopy analysers to industrial fermentation processes has been hindered by problems related to the high background fluorescence signal associated with the analysis of biological samples. To address this issue, we investigated the influence of fluorescence on the spectra collected from two Raman spectroscopic devices with different wavelengths and detectors in the analysis of the critical process parameters (CPPs) and critical quality attributes (CQAs) of a fungal fermentation process. The spectra collected using a Raman analyser with the shorter wavelength (903 nm) and a charged coupled device detector (CCD) was corrupted by high fluorescence and was therefore unusable in the prediction of these CPPs and CQAs. In contrast, the spectra collected using a Raman analyser with the longer wavelength (993 nm) and an indium gallium arsenide (InGaAs) detector was only moderately affected by fluorescence and enabled the generation of accurate estimates of the fermentation’s critical variables. This novel work is the first direct comparison of two different Raman spectroscopy probes on the same process highlighting the significant detrimental effect caused by high fluorescence on spectra recorded throughout fermentation runs. Furthermore, this paper demonstrates the importance of correctly selecting both the incident wavelength and detector material type of the Raman spectroscopy devices to ensure corrupting fluorescence is minimised during bioprocess monitoring applications.
Interaction of rRNA with mRNA and tRNA in Translating Mammalian Ribosome: Functional Implications in Health and Disease
Authors: Bastide Amandine , David Alexandre
Published: September 2018

RNA-RNA interaction slowly emerges as a critical component for the smooth functioning of gene expression processes, in particular in translation where the central actor is an RNA powered molecular machine. Overall, ribosome dynamic results from sequential interactions between three main RNA species: ribosomal, transfer and messenger RNA (rRNA, tRNA and mRNA). In recent decades, special attention has been paid to the physical principles governing codon-anticodon pairing, whereas individual RNA positioning mostly relies on ribosomal RNA framework. Here, we provide a brief overview on the actual knowledge of RNA infrastructure throughout the process of translation in mammalian cells: where and how do these physical contacts occur? What are their potential roles and functions? Are they involved in disease development? What will be the main challenges ahead?
Peace ‘at Last Sight’: The Other Face of ‘Warchitecture’
Authors: Saifi Yara , Hürol Yonca
Published: September 2018

The first part of the title of this article purposefully recalls Walter Benjamin’s interpretation of ‘love at last sight’ in connection with Charles Baudelaire’s famous poem entitled ‘To a Passerby’ in his famous book ‘The Flowers of Evil’. The poem was written about a lost chance of love. Within the title of this article it is used in relation to the concept of peace. The other part of the title contains Andrew Herscher’s concept of ‘warchitecture’, which is used to describe destroyed or semi destroyed pieces of architecture in political conflict zones. The paper intendeds to represent another face of warchitecture, which has nothing to do with physical destruction. By making value judgements regarding examples of architectural aesthetics, which exist within a long-term conflict zone—Jerusalem; Mosche Safdie’s David Village and Santiago Calatrava’s Bridge of Strings will be discussed. Peacefully they may stand in their appearance, they express a ‘nonbeing peace’ when analyzed in relation to their context. Accordingly, this paper questions both buildings’ attempts to peace and harmony when discrimination is taking place against Palestinians in Jerusalem. By articulating the relationship between the representation of ‘nonbeing’ and the destruction of buildings’ ‘warchitecture’ during wars, the paper shows that neglect can be another tool of destruction towards Palestinians and their culture.
The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers
Authors: Eissa Ibrahim , Bustos-Villalobos Itzel , Ichinose Toru , Matsumura Shigeru , Naoe Yoshinori , Miyajima Noriyuki , Morimoto Daishi , Mukoyama Nobuaki , Zhiwen Wu , Tanaka Maki , Hasegawa Hitoki , Sumigama Seiji , Aleksic Branko , Kodera Yasuhiro , Kasuya Hideki
Published: September 2018

Oncolytic viral therapy has been accepted as a standard immunotherapy since talimogene laherparepvec (T-VEC, Imlygic®) was approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for melanoma treatment in 2015. Various oncolytic viruses (OVs), such as HF10 (Canerpaturev—C-REV) and CVA21 (CAVATAK), are now actively being developed in phase II as monotherapies, or in combination with immune checkpoint inhibitors against melanoma. Moreover, in glioma, several OVs have clearly demonstrated both safety and a promising efficacy in the phase I clinical trials. Additionally, the safety of several OVs, such as pelareorep (Reolysin®), proved their safety and efficacy in combination with paclitaxel in breast cancer patients, but the outcomes of OVs as monotherapy against breast cancer have not provided a clear therapeutic strategy for OVs. The clinical trials of OVs against pancreatic cancer have not yet demonstrated efficacy as either monotherapy or as part of combination therapy. However, there are several oncolytic viruses that have successfully proved their efficacy in different preclinical models. In this review, we mainly focused on the oncolytic viruses that transitioned into clinical trials against melanoma, glioma, pancreatic, and breast cancers. Hence, we described the current status and future prospects of OVs clinical trials against melanoma, glioma, pancreatic, and breast cancers.