bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization strategy of AC / DC hybrid energy supply in multi energy system considering adiabatic compressed air energy storage device and comprehensive demand response
Authors: Men Jiakai , Qiu Jianlong , Chen Xiangyong
Published: August 2022

Regional multi energy system (RMES)has advantages in meeting the diversified needs of energy and improving energy efficiency. In this paper, with the increase of DC power sources such as photovoltaic power generation and fuel cells, it is difficult for batteries to fully improve energy utilization efficiency and solve the problem of large-scale consumption of clean energy power. An adiabatic compressed air energy storage (A-CAES) device is established, and RMES model considering integrated demand response (IDR) is considered. As the most potential energy storage device at present, A-CAES device can better promote the absorption of new energy such as wind energy and photovoltaic, effectively utilize traditional energy and reduce the environmental pollution caused by RMES. Improve the ”multi-energy complementary” energy supply mode adopted by RMES through A-CAES. IDR is adopted to improve the economy and flexibility of integrated energy system. The results show that the total operating cost of the model established in this paper is significantly reduced, which is effective and feasible to promote new energy consumption, energy conservation and emission reduction.
P- element Induced Wimpy Testis (PIWI), a Novel Powerful Candidate Diagnostic Marker for Hepatocellular Carcinoma
Authors: Hammad Gehan , Mamdouh Samah , Seoudi Dina Mohamed , Seleem Mohamed Ismail , Safwat Gehan , Mohamed Rania Hassan
Published: August 2022

P-Element-induced wimpy testis (PIWI) proteins are engaged in epigenetic regulation of gene expression in germline cells when they are in combination with PIWI-interacting RNA (piRNA). Different types of tumour cells have been found to exhibit abnormal expression of piRNA and PIWI proteins. HCC is majorly diagnosed in later stages, which is associated with lower survival rates. There is an urgent need for improved, more specific and less invasive diagnostic methods that can detect earlier stages of the disease. Purpose: The aim of this study was to assess the diagnostic potential by determining the expression profiles of PIWI-like protein-1, -2, -3, & -4 (PIWIL1, PIWIL2, PIWIL3, & PIWIL4) in hepatocellular carcinoma, and determine its association with clinicopathological features. Methods: Samples from patients comprising serum and frozen fragments of paired tissue specimens (tumour and adjacent non-malignant liver tissue) were employed for molecular analyses. Real-time polymerase chain reaction was performed on 50 tissue and serum samples from HCC patients and 25 serum samples from healthy controls. Results: The PIWIL1, PIWIL2, PIWIL3, & PIWIL4 levels were significantly (<0.001) higher in both HCC tissue and serum samples than in the controls. Additionally, the diagnostic performance was assessed by ROC curves, the PIWIL1-4 levels in serum showed better potential and sensitivity to screen HCC patients than their levels in tissues. Moreover, some PIWIL elements were found here to be significantly correlated with the HCC profile. Conclusion: PIWI expression is considered as a powerful non-invasive diagnostic tool for HCC. Our findings also support the theory that PIWIL expression is critical for cancer progression.
Optimization for better Immunohistochemistry assay and more comprehensive pathological interpretation for PD-L1 expression in Classical Hodgkin lymphoma
Authors: SHI YUNFEI , Lan Mi , Lai Yumei , Zhao Min , Jia Ling , Du Tingting , Song Yuqin , Li Xianghong
Published: August 2022

Bckgoround:Treating the relapsed or refractory Classical Hodgkin Lymphomas were still challenging, previous studies indicated they can benefit from immune checkpoint inhibitors, over expression of PD-L1 can also be predictive marker for anti -PD -1 therapeutic efficacy, however, harmonization with different IHC assay s and explanation of the PD -L1 immunostaining results remains controversial in CHL. In this study, we sought to optimize the PD-L1 Immunohistochemistry (IHC) assay in classical Hodgkin lymphoma (CHL). Methods: All tests were performed on tumor tissue microarray established from 54 CHLs. Three IHC assays (405.9A11, SP142, 22C3) for PD-L1 expression were compared semi-quantitatively with RNAscope assay (No. 310035, ACD), and the difference for their expression on background immune cells (ICs), their associations with densities of TIL/TAM makers and their implication on survival were also analyzed. Results: 405.9A11 assay demonstrated best specificity on HRS cells and sensitivity on ICs. Thus, positive expression of PD-L1 was more frequent on ICs (85.2%) than on HRS cells (48.1%). Different subgroups of background IC cells including tumor associated macrophages (TAMs) were assessed and scored by CD4, CD8, FOXP3, and CD163. PD-L1 expression on ICs were most associated with elevated densities of TAMs, and in concordance with TAMs(P=0.026), PD-L1 expression on ICs ( P=0.067)indicated a negative effect on survival.Conclusions: 405.9A11 assay was proved to be most convincible for demonstrating PD-L1 expression，pathologists should report PD-L1 expression in a combined manner including both positive status of HRS cells and positive percentage of ICs.
Survey of Image Anomaly Detection
Authors: Ghamry Fatma M. , El-Banby Ghada , El-Fishawy Adel S. , El-Samie Fathi E. Abd , Dessouky Moawad I.
Published: August 2022

The phrase "anomaly detection" is often used to refer to any technique that seeks to find samples that differ from expected patterns. Depending on the availability of data labels, the types of abnormalities, and the applications, many anomaly detection models are developed. This study aims to give a well-organized and thorough review of anomaly detection research. We think it will aid in a superior thoughtful of the various areas in which study has been conducted on this issue, as well as how approaches created in one field can be utilized in domains where they were not originally intended. We've divided the anomaly detection research methodologies into distinct categories. We describe the fundamental anomaly detection approach, as well as its modifications and important assumptions, for distinguishing between normal and abnormal behavior in each category. In addition, we highlight the merits and limits of each category, as well as examine the computational complexity of the approaches in real-world application areas. Finally, we discuss research gaps and limitations encountered when using deep anomaly detection algorithms to solve real-world problems.
Prediction of superconducting properties of materials based on machine learning models
Authors: Jiang Yongquan , Jie Hu , Yan Yang , Siqi Yu , Houchen Zuo
Published: August 2022

Superconducting materials have extremely high application value in our life. At present, the discovery of new superconducting materials relies on the experience of experts through a large number of "trial and error" experiments. Obtaining the properties of superconductors also requires a large number of experiments. In this paper, we propose to use the XGBoost model to identify superconductors, reaching 0.986 in accuracy. We apply the deep forest algorithm to predict the critical temperature of superconductors and the coefficient of determination reaches 0.944. We propose to apply the same algorithm to predict the forbidden band width of materials and the coefficient of determination reaches 0.917. A new sub-network structure is constructed to predict the Fermi level of materials and the coefficient of determination reaches 0.984. All of these algorithms have state-of-the-art performance. Finally, the model is tested with a publicly available dataset to identify 50 candidate superconducting materials with a critical temperature greater than 90K.
Quality of Life in multiple scenarios: The impact of work mode and social contact quantity
Authors: Leng Cheng-Han , Tsai Chi-Shiun , Chan Ta-Chien , Lee Hsuan-Wei
Published: August 2022

Background This study aims to explore issues, such as (i) whether there is a difference in quality of life (QoL) among subgroups of the work mode (working from home (WFH) vs. working in the office (WIO)), social contact quantity, and face contact ratio; (ii) whether employees' QoL is moderated by the social contact quantity and face contact ratio given their work mode; (iii) whether the three-way interaction effect of work mode, social contact quantity, and face contact ratio on employee's QoL is significant; and (iv) whether the WHOQOL-BREF invariantly measures for the subgroups of the work mode, social contact quantity, and face contact ratio. Methods We assessed the QoL of 803 WFH employees and 588 WIO employees during the same time period and divided them into sixteen groups resulting from the levels of work mode, social contact quantity, and face contact ratio, forming a case-control study. A differential item functioning (DIF) analysis was used for analyzing the responses on the WHOQOL-BREF under the 4-dimensional rating scale model fitting. Results Our results indicated that WFH employees’ QoL was superior to that of WIO employees [χ2(1) = 8.52, p = 0.0035]. However, since the work mode was moderated by the social contact quantity [χ2(3) = 10.89, p = .012] and face contact ratio [χ2(1) = 11.39, p < .001], WFH employees’ QoL was worse than that of WIO employees if their amount of social contact was low and if most social contacts were not face-to-face. Moreover, WFH employees’ QoL was better than WIF employees’ QoL when most contacts were not face-to-face and the number of social contacts was high [χ2(3) = 9.07, p = .028]. Besides, the WHOQOL-BREF measured employees’ QoL biasedly as many facets of the WHOQOL-BREF were found to diverge among subgroups of the work mode and social contact quantity.Conclusions The WFH mode was practical in the COVID-19 pandemic. However, maintaining social connections is equally important so that employees can maintain good performance in jobs. The facets detected as DIF items provided implications for QoL research methodology and insight into factors affecting employees' QoL.
Quantitative Systems Modeling Approaches Towards Model-Informed Drug Development: Perspective Through Case Studies
Authors: Verma Meghna , Gall Louis , Biasetti Jacopo , Veroli Giovanni Di , Pichardo-Almarza Cesar , Kimko Holly
Published: August 2022

Quantitative systems pharmacology modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions. In this paper, we present examples of QSP modeling applications to highlight the notable contributions and opportunities that these approaches are to offer during the drug development process. We also consider the barriers to successful applications; outline the factors required to support the success of these modeling approaches; and provide insights for a strategy to enhance acceptance by the regulatory agencies.
Towards the reliability check of complementary methods for the precise estimation of peak efficiency of a long run used Germanium detector in low activity environmental measurements
Authors: Margret  , S Chandrasekaran , C.V Srinivas , B Venkatraman
Published: August 2022

The gamma-ray spectrometry using long run used hyper pure germanium(HPGe) detector needs a stringent full energy peak(FEP) efficiency calibration for environmental radioactivity measurements. The FEP efficiency calibration were carried out using the complementary methods like analytical estimations and Monte Carlo(MC) simulations. In our work, for the analytical estimations, the relative deviation of the theoretical results with that of experimental FEP efficiency was found to be less than 6%. But in the case of MC methodologies, an overall estimated standard deviation of 5% could be achievable only with the optimized geometry of the long run used germanium detector for low-activity environmental measurements.
Dust-acoustic periodic travelling waves in a magnetized dusty plasma with trapped ions and nonthermal electrons in astrophysical situations:Oblique excitations
Authors: El-Shamy E. F. , Selim M. M.
Published: August 2022

Obliquely propagating three-dimensional dust-acoustic periodic travelling waves (DAPTWs) has been undertakenin a magnetized dusty plasma composed of negatively charged inertial dust particles, trapped ions, and nonthermal fast electrons. In a dusty plasma model at hand, the dynamic behaviors of DAPTWs are governed by a Schamel equation. The presence of dust acoustic solitary waves (DASWs) and DAPTWs is investigated via bifurcation analysis of the Hamiltonian system. In the nonlinear regime, the Sagdeev potential and phase portrait structures indicate the presence of small-amplitude DAPTW solutions. The influences of intrinsic physical parameters include the strength of the static magnetic field, the obliqueness of propagation,the thermal pressure of charged dust grains, the electron to dust density ratio, the trapping parameter of trapped ions and the degree of nonthermality of fast electrons on the characteristics of DAPTWs are simulated numerically. In particular, the findings illustrate that the amplitude of DAPTWs is reduced as the numerical values of the trapping parameterare decreased. Interestingly, the numerical results of the theoretical simulations can be used to significantly highlight the physical nature of DAPTWs in astrophysical situations such as Earth’s magnetosphere, auroral region, and heliospheric environments.
Are we ready yet for digital transformation? Virtual versus On-Campus Objective Structured Clinical Examination (OSCE) as an assessment tools in pharmacy education. A randomized controlled head-to-head comparative assessment
Authors: Kharaba Zelal , Ahmed Mohammad Al , Elnour Asim Ahmed , AbouHajal Abdallah , Abumweis Suhad , Ghattas Mohammad A.
Published: August 2022

Background: The global COVID-19 pandemic has influenced pharmacy education including learning, assessment, and exams. In the UAE, pharmacy instructors have adapted several innovative teaching methods to strive for quality learning outcomes. The current trial presented a head-to-head comparative assessment between on-campus versus virtual Objective Subjective Clinical Examination (OSCE) with examiners’ and students’ perspectives. Aim: The main aim was to compare fourth-year students’ and examiners’ perceptions of the feasibility (time and logistics), stress, performance, and satisfaction between on-campus versus virtual OSCE. Method A randomized controlled head-to-head comparative assessment between the On-campus and virtual OSCE was conducted to explore performance and satisfaction of pharmacy students and examiners towards the two OSCE settings. The virtual OSCE was carried out directly after the on-campus -OSCE and the setting was designed in a way that aligned with the on-campus OSCE but in a virtual way. Microsoft Teams® breakout room was used as a virtual stations. Respondus-lockdown-browse and Google Meet® were used for proctoring purposes. Results: Students who sat for the on-campus assessment were more satisfied with the instructions, the orientation session, the time management, and the overall exam setting, the ability of the exam to assess their communication and clinical skills, professionalism and attitude, and the interactivity of the exam compared to the students who sat for the virtual assessment. Examiners’ perceptions for both settings were the same with the exception of interaction with students (p<0.05) as the on-campus OSCE was more interactive. Conclusion: Students still prefer the on-campus OSCE to the virtual OSCE format in many aspects. Nevertheless, virtual OSCE is still a feasible and satisfactory method of assessment when on-campus OSCE is not possible. There is a need of a specialized platform to conduct the virtual OSCE from A to Z rather than maximizing the use of options in the current digital platforms.
The Prediction of Global Mean Temperature through Machine Learning
Authors: Niyogi Debdarsan , Sriniva Jayaraman
Published: August 2022

Global Mean Temperature (GMT) is a very important variable to be predicted based on its history. The fluctuations in GMT might not be describable by exact mathematical modelling since the underlying Physics is not yet understood fully, and a data-driven approach to this problem is an alternative worth exploring. A variety of data-driven algorithms in Machine Learning (ML) and Deep Learning Neural Networks (DNN) are available for predicting time series. However, advanced algorithms, like DNN are complex to implement and computationally expensive. In this article, only simple ML methods have been evaluated to predict GMT treating it both as a univariate time series and also casting it to a regression problem. The effectiveness of a large set of simpler ML methods along with different data preparation techniques to forecast the GMT and mean value of GMT over a span of years was examined. It was found that some simple methods did as well or better than the more well-known ones showing merit in trying a large bouquet of algorithms as a first step. Forecasts were satisfactory with an RMSE value of around 0.056 on average, with the lowest value of 0.02. RMSE for mean GMT values ranged from 0.00002 to 0.00036. This establishes a benchmark for the more advanced ML models to reach. Some steps of data preparation were shown to be effective. Application of DNN is recommended to examine if that is capable of predicting GMT with greater accuracy.
Evaluation of a Transition to Survivorship Program for Pediatric, Adolescent and Young Adult Cancer Patients and Caregivers
Authors: Bingen Kristin , Karst Jeffrey , Anderson Lynnette , Chan Sherilynn , Jordan Anna , Morin Jocelyn , Nichols Julie , Palou-Torres Akasha , Phelan Rachel , Schmidt Debra , Yan Ke , Hoag Jennifer A
Published: August 2022

PurposeSurvivorship education and anticipatory guidance represents an unmet need for pediatric, adolescent, and young adult (AYA) cancer survivors and their caregivers when treatment ends. This pilot study evaluated the feasibility, acceptability, and preliminary efficacy of a structured transition program, bridging treatment to survivorship, to reduce distress and anxiety and increase perceived preparedness for survivors and caregivers.MethodsBridge to Next Steps is a 2-visit program, within 8 weeks of treatment completion and 7 months post-treatment, which provides survivorship education, psychosocial screening, and resources. Fifty survivors and 46 caregivers participated. Participants completed pre- and post-intervention measures: Distress Thermometer and PROMIS anxiety/emotional distress (ages ≥ 8 years), and perceived preparedness survey (ages ≥ 14 years). AYA survivors and caregivers completed a post-intervention acceptability survey.ResultsMost participants (92.59%) completed both visits, and most AYA survivors (57.1%) and caregivers (76.5%) endorsed the program as helpful. Caregivers’ distress and anxiety scores decreased from pre- to post-intervention (p < 0.01). Survivors’ scores remained the same, which were low at baseline. Participants felt more prepared for survivorship from pre- to post-intervention (p = 0.02, p < 0.01, respectively).ConclusionsBridge to Next Steps was feasible and acceptable for most participants. AYA survivors and caregivers felt more prepared for survivorship care after participation. Caregivers reported decreased anxiety and distress from pre- to post-Bridge, whereas survivors remained at a low level for both.Implications for Cancer SurvivorsEffective transition programs that better prepare and support pediatric and AYA cancer survivors and families from active treatment to survivorship care will contribute to healthy adjustment.
Relationship Between Freshwater Harmful Algal Blooms and Neurogenerative Disease Incidence Rates in South Korea
Authors: Lee Seungjun , Choi Boseung , Kim Sung Jae , Kim Jinnam , Kang Dayun , Lee Jiyoung
Published: August 2022

Background: Due to anthropogenic activities and global warming, the severity and distribution of harmful algal blooms (HABs) have been increasing steadily worldwide, including in South Korea (S. Korea). Previous studies reported exposure to HABs can increase the risk of HAB-related diseases. However, very few studies examined the linkage between HABs and disease occurrence, particularly in S. Korea. The objective of this study was to evaluate the potential impact of HABs on neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, and motor neuron disease, at a population level. Methods: Thirteen year data (2005-2017) for chlorophyll-a (chl-a) concentrations as a bloom-related parameter, annual numbers of NDs and population information were collected. First, the entire area of S. Korea was divided into a grid of 1-km and the population number in each 1-km grid was collected using Statistical Geographic Information Service Plus system. Cross-sectional time series data were analyzed with two statistical models, a generalized linear mixed model and a generalized linear model.Results: The results show that there is a general trend of increasing chl-a concentration and NDs year by year. We observed positive correlations between HAB intensity and incidence rate of NDs. Particularly, HABs seem to have the most long-term carry-over effect on Parkinson’s disease. Another key finding was that a 5-km radius from the HAB location was the boundary that showed most significant associations with three NDs. Conclusions: This study provides statistical evidence that supports the potential risk of NDs from the exposures of HAB. Thus, it is recommended to monitor a broad spectrum of cyanotoxins, including neurotoxins, in the areas of bloom-affected regions in S. Korea as well as epidemiological studies in the future.
Characteristics, challenges, benefits, and technologies of Smart Grid (SG): survey
Authors: Abdullah Ahmed. A.
Published: August 2022

The electric power system is undergoing considerable changes in operation, maintenance, and planning as a result of the integration of renewable energy resources (RERs). The transition to a smart grid (SG), which employs advanced automation and control techniques, brings with it new difficulties and possibilities. This paper provides an overview of next-generation smart grids by presenting the most current and cutting-edge developments in the SG sector. This paper discusses the benefits, drawbacks, and prospects of smart grids. The difficulties of integrating RERs into the grid, as well as alternative energy storage solutions, are discussed. The unpredictable nature of resources has an impact on RER output. The energy storage system is critical in dealing with RERs' unpredictable nature and ensuring a smooth and reliable supply to load demand. Smart energy systems provide a number of problems and possibilities in terms of developing, integrating, and implementing electrical grids that incorporate network and communication technologies, as well as important privacy and security concerns for various components within the grid. This paper also shows the influence of SGs on distributed energy generation, as well as a comparative analysis on electric cars (EVs), including classification, i.e., battery, and hybrid electric vehicles, as well as current difficulties and challenges in EV technology. A discussion of SG protection concerns and their resolution is also included.
Recovery Time from Total Disability Glare is Increased in Myopic Eyes
Authors: Ávila Francisco J. , Casado Pilar , Ares Jorge
Published: August 2022

Purpose
To investigate differences between myopic and emmetropic eyes in the measured recovery time after retinal photobleaching in a population of young healthy subjects.
Methods
A Maxwellian-illumination total disability glare instrument with controllable glare angular distribution, luminous intensity and contrast of the visual stimuli was employed to measure the recovery time after photo-stress induced vision for a 240 milliseconds exposure time in 66 myopic and 66 emmetropic eyes. The measurements were carried out for different combinations of glare angles and contrast of the visual stimuli.
Results
Time recovery measured in myopic eyes is significantly higher than emmetropic eyes. The measured recovery depends on both the glare angle and the contrast of the stimuli. In addition, myopic and emmetropic eyes present similar sensitivity to glare in terms of time recovery, however in glare conditions, the differences of measured recovery time drastically increase with the reduction of the contrast of the stimuli between both groups of study.
Conclusions
A total disability glare instrument has been employed to stablish the differences in the measured recovery time after retinal photobleaching. The versatility and simplicity of the instrument could help to explore those retinal disorders related to photopigment visual function at both central and peripheral retina.
Existence of solutions for some classes of integro-differential equations on C1(R+) by applying a measure of noncompactness
Authors: Tamimi Hengameh , Saiedinezhad Somayeh , Ghaemi Mohammad Bagher
Published: August 2022

This paper introduces sufficient conditions for the existence of solutions in some classes of integro-differential equations. Due to Darbo's fixed point theorem with an appropriate measure of noncompactness, we prove the existence of solution in each class of equations. Finally, some significant examples are solved using the artificial small parameter method.Mathematics Subject Classification (2010). 47H10, 45J05, 47H08.
Ultrasound assisted exploration of the primary anatomical dimension of lumbar epidural fat affecting epidural labour analgesia
Authors: Xu Chenyang , Guo Wenjun , Zhang Peijin , Yuan Hongmei , Feng Shanwu
Published: August 2022

Background: There is ambivalence about the effect of epidural fat on local anaesthetic diffusion in epidural anaesthesia. This study aimed to investigate the primary anatomical dimension of epidural fat affecting epidural labour analgesia using ultrasound measurements of the ligamentum flavum-dura mater unit (LFDM).Methods: A total of 162 women who received epidural labour analgesia were included in this study. The height (H), diameter (d), and volume (V) of the lumbar LFDM were measured and calculated using ultrasound as a proxy for the dimensions of epidural fat. After anaesthesia, the main observations were whether the analgesia was effective within 30 min and the changes in the levels of temperature and pain blockade within 30 min.Results: A total of 160 patients completed the follow-up. The height (H) of the LFDM (AUC=0.882) was more predictive of maternal analgesia than the volume (V) of the LFDM (AUC=0.667). Although the volume (V) of the LFDM was weakly correlated with the temperature block level (r=-0.423, P<0.0001) and pain block level (r=-0.459, P<0.0001), the height (H) of the LFDM was strongly correlated with the temperature block level (r=-0.864, P<0.0001) and pain block level (r=-0.811, P<0.0001). With a height (H) of LFDM =12.06 as the cutoff, the sensory block level was significantly higher in the short LFDM group than in the long LFDM group within 30 min.Conclusion: The height (H) of the lumbar LFDM, as determined by ultrasound, rather than its volume, is the primary anatomical dimension of epidural fat that affects epidural labour analgesia.
Seed Oil Content and Variability of Some Provenance of Jatropha Curcas Population in Ethiopia
Authors: Eshetu Reta , Minale Mesafint , Tedla Abeje
Published: August 2022

Background: Jatropha curcas (L.) is drought resistant large shrub or small tree. It belongs to the genus Jatropha and the family Euphorbiaceae. It is native to tropical America, but now found abundantly in many tropical and sub-tropical regions. Jatropha curcas (L.) is one of the important species that bear seed containing oil with a potential use as biodiesel. The objective of this research is to estimate the seed oil content and variability for some tree morphological traits of Jatropha curcas population in Ethiopia. Methodology: Fourteen Jatropha curcas populations were collected at different parts of Ethiopia. Sixteen plants per plot were planted at Shewarobit site in randomized complete block design with three replications. Data on survival rate, number of branches, seed yields and growth parameters were collected from those plants. Results: The result showed that a survival rate of 85-100%, average root collar diameter was 11cm and plant height of 235 cm were recorded at the age of 39 months after planting. Different traits of Jatropha curcas indicated statistically no significant difference (p>0.05). However, slightly higher seed and oil yield (k.g/ha/year) 3016.0 & 111169.8, 2711.3 & 91235.25 were found from Chefa and R1-009 seed sources, respectively. Conclusions: Even if, there was no significant difference observed among seed sources. Hence, Chefa and R1-009 collections have slightly greater yield both in seed and oil yields. So they should be chosen for future seed sources to produce crude oil due to their relative higher seed number and oil yield.
miR-19b-3p inhibits glioma progression via interacting with lncRNA HAGLR
Authors: Qi Xuchen , Liu Yiwei , Lu Qin , Wang Yirong , Yang Shuxu
Published: August 2022

LncRNA HOXD-AS1, alias HAGLR, was reported to be a tumor promoter and involved in the induction of chemoresistance in glioma. This study was designed to infer the potential miRNA which bound with HAGLR and contributed to tumor growth in glioma. Specifically, two miRNAs (miR-17b-5p and miR-19b-3p) targeted were selected by HAGLR in glioma cells. Then we constructed miRNA-overexpression vectors and transfected into U87 cells to establish experimental cell models. CCK-8 assay was applied to examine cell viability and the cell group with miR-19b-3p upregulation exhibited a stronger inhibition on cell growth, which therefore was selected for the following experiments. Transwell assay and flow cytometry were then utilized to detect cell migration and apoptosis and dual-luciferase reporter assay was used for examining the combination of HAGLR and miR-19b-3p. The results suggested that miR-19b-3p overexpression significantly decreased cell migration but increased cell apoptosis. Moreover, upregulated miR-19b-3p considerably reduced the relative luciferase activity of the wild-type, rather than the mutant HAGLR-harboring U87 cells, indicating that HAGLR was identified as the target of miR-19b-3p. This study identified a novel HAGLR/miR-19b-3p regulation axis in cellular activities of glioma cells, which provided a preliminary theoretical basis for further research on underlying molecular mechanisms.
Are gender norms systematic to caste institutions? Examining preferences through a social experiment in India
Authors: Dasgupta Aparajita , Datta Ashokankur
Published: August 2022

In this paper we examine how traditional institutions like caste interact with socio-economic status to mediate the perception of gender roles and attitudes around female labour force participation. We use third party vignettes to directly test the validity of the hypothesis that lower castes have more egalitarian gender norms and lower acceptance of restrictions on female autonomy. We find that the relationship between conservative gender norms and caste are in turn influenced by the class status of households, measured by land or asset ownership. Lastly, we conduct a simple social experiment to test for `pluralistic ignorance' and confirm the presence of systematic overestimation of conservative attitude that varies by caste and class identities.JEL Codes: J16, J21, J22, Z13
Linear programming the Ramsar Convention’s Criterion IV in the Shadegan Wetland; enlisting the wetland should it support waterfowl and waders under extreme climate conditions
Authors: Rafei Asma , Danehkar Afshin , Zandebasiri Mehdi , Goodarzi Mehdi Sheikh
Published: August 2022

Wetland ecosystems around the world are of great importance in terms of providing valuable ecological services to people and wildlife. According to the Montreux Record, there is a list of wetlands which failed to fulfill the Ramsar Convention’s criteria. The Shadegan international site, registered in 1975 as a Ramsar Convention member, has been subjecting to the Montreux record since 1993 owning to the conditions change. The purpose of this study was to apply linear programming (LP) to measure the status of Criterion IV of the Ramsar Convention over the extent of Shadegan Wetland. Accordingly, Criterion IV was defined in mathematical language and run by the Excel software. The Lingo software was also used to verify the previously retrieved linear model by defining constraints for X variables. The constraints of this model were chosen based on the extreme events (i.e. evaporation threshold was determined based on water and energy limitations) of each variable during the study period considering the trend effect of each variable.
Board Diversity and its Impact on Firm Performance
Authors: Hasan Fakhrul , Islam Mohammad Raijul
Published: August 2022

This study aims to examine and interpret the relationship between the demographic diversity of the board and firm performance. We used the FTSE 100 Index to do this research along with the longitudinal (panel) data. The use of the Blau index and the coefficient of variations helps define the demographic diversity value of the board. We used ROE as a dependent variable for our base line mode and ROA for our robustness test. The results of this study indicate that demographic diversity is positively related to firm performance. This study manages to discover a significantly negative relationship between gender diversity and ROE, as well as a significantly positive relationship between gender diversity and ROA. A significantly negative correlation is also found between CEO age and ROA and a significantly, positive correlation between board tenure and ROE.
Esports and Traditional sports players: An exploration of psychosocial profile
Authors: Singh Priya , Sharma Manoj Kumar , Arya Sidharth
Published: August 2022

Background: The commercial association has made computer-based games very attractive, providing a platform where they are being considered on similar lines as traditional/real sports. However, despite the similarities there exists considerable difference primarily because of extent of physical involvement. The study intended to explore the psychosocial profile of Esports players and traditional sports players. Methods: The study sample consisted of 140 participants (73 esports & 67 sports). In this cross-sectional study, we recruited participants from Esports cafes, Youth Sports centers & Universities and collected their sociodemographic variables and psychosocial profile with Mini-International Personality Pool 6, Self-Concept Clarity Scale, UCLA Loneliness Scale Version 3, Satisfaction with Life Scale, and Depression, Anxiety and Stress Scale-21. Results: The mean age of Esports and sports players were 23.11± 4.60 years and 22.24± 3.22 years respectively. Both category of players differed in term of hours of play on weekdays/weekend, process of introduction to games, engagement of family and methods used to improve game play. For Psychological variables, esports players were likely to report significant higher scores on openness (β= -0.151, CI=.769-.962) and honesty/Humility (β= -0.151, CI=.672-.863) compared to sports players but not on other variables of depression, anxiety, stress, loneliness, self-concept and satisfaction with life. Conclusions: Our study points out that despite differing in Socio-demographic and playing variables, esports and sports players tend to exhibit much similarity in psychological domains. Further longitudinal studies are warranted to extend the application and generalizability of our study results.
Impact of reinforcement on load-settlement behavior of a strip footing adjacent to granular soils-excavation
Authors: Ahmad Hussein
Published: August 2022

Improvement the granular soils by the inclusion geogrid makes to increase the load-settlement behavior of strip footing-soil-sheet wall system. The lack of urban land, usually the construction of new buildings adjacent to the old buildings are used. To this end, excavation is required. There is less information on the behavior of surface foundations adjacent to an excavation. In the present work, a series of numerical studies using an analysis of finite elements in reinforced and unreinforced granular soils adjacent to excavations loaded with a strip footing were carried out using two granular types soil. Therefore, selecting the hardening soil model (HSM) to simulate the granular soils behavior is utilized. This work aimed to define the impact of the geogrid reinforcement on load-settlement of that footing, suggest an optimal number of reinforcements, and investigate the behavior of two closed footings adjacent the pit. The research was carried out on sandy excavations (H=3B) by altering the distance between the footing from the edge of the various granular excavations. Various geogrid layers were used to achieve the highest bearing capacity. It is demonstrated that the final settlements of the footings can be greatly decreased by both existing three reinforcement layer and increasing the setback of pit. In this study, it was obtained that for granular soils using three layers of reinforcement, the final loading capacity of it will be considerably increased. Moreover, it is obvious that the final bearing capacity will increment in a non-linear manner by incrementing the distance from the edge of the excavation. As a result, a lot of care should be done to determine the footing location. Finally, the placement of foundations adjacent to each other increases their bearing capacity and efficiency factor. In the ratio of the distances between the surface foundations (D) beyond 5 times the foundation width (B), the effect of interference is negligible.
Discovery and Characterization of Novel Fertile Triploids and a New Chromosome Number in Caladium (Caladium × hortulanum)
Authors: Parrish S. Brooks , Deng Zhanao
Published: August 2022

Cultivated caladium (Caladium × hortulanum; 2n = 2x = 30) is an important ornamental aroid for the environmental horticulture industry. A better understanding of its genetic diversity is needed for continued improvement of caladium. The caladium germplasm maintained in the University of Florida’s caladium breeding program were surveyed for potential variation in chromosome number and nuclear DNA content to gain a better understanding of caladium genetic diversity at the cytogenetic level. For the first time caladium triploidy was discovered in two breeding lines, UF-15-414 and UF-4407 with 2n = 3x = 45 chromosomes and a nuclear DNA content of 13.86 pg·2C−1. In addition, a new chromosome number (2n = 2x = 34) was found in one cultivar, ‘White Wing’. Compared with their diploid parents or grandparents, the triploids showed a distinct, attractive leaf morphology with rounder and thicker leaves. The pollen stainability of UF-15-414 and UF-4407 was 63% and 73%, respectively, indicating potential male fertility, which was unexpected. Analysis of simple sequence repeat (SSR) marker banding patterns confirmed that UF-15-414 was a direct progeny of UF-4407 through hybridization with the diploid cultivar Aaron, whereas UF-4407 might result from fusion of an unreduced (female or male) gamete with a reduced gamete. Chromosome counting and SSR marker analysis of ‘White Wing’ and its progeny cultivars ‘White Wonder’ and ‘White Delight’ suggested that ‘White Wing’ possibly transmitted its 34 chromosomes to progeny during sexual reproduction. The discovery and characterization of these triploids revealed the occurrence of natural sexual polyploidization in caladium and indicated good potential for creating and selecting new triploids for future caladium breeding. The observed new chromosome number in ‘White Wing’ and its progeny cultivars implies that other chromosome variations may be present among cultivated caladiums. In summary, these results revealed two male-fertile triploid caladiums and a new chromosome number that can enrich the cytogenetic diversity in future caladium cultivar development.
New Mineral Names: Hydrous Minerals
Authors: Celestian Aaron J.
Published: August 2022

In this issue of New Mineral Names, a thematic approach is used to help provide context for advances and discoveries in mineralogy. There have been many new minerals described within the last year that have important H2O-OH groups within the crystal structure and/or have been formed by hydrothermal processes. Here we investigate the newly discovered hydrous minerals: taniajacoite, strontioruizite, flaggite, steudelite, whiteite-(MnMnMn), zolotarevite, garpenbergite, dobšináite, galeaclolusite, relianceite-(K), and hydroplumboelsmoreite.
ENFORCEMENT OF JUDICIAL ACTS ON HOUSING DISPUTES: GAPS IN LEGISLATION
Authors: Ivanov Nikolai Vasilevich , Taborkina Anna Gennadevna
Published: August 2022

The article provides an overview of some gaps in the legislation on enforcement proceedings, in terms of general and special issues related to the enforcement of judicial acts on housing disputes, taking into account the analysis of judicial practice
The position of Korean women during the period of Japanese colonial rule (1905-1945)
Authors: Fediunina Marina Andreevna
Published: August 2022

The article examines the transformation of the position of women in the context of the colonization of Korea. The forced "discovery" of Korea in the second half of the 19th century made it vulnerable to developed states: in the course of the struggle for a new sphere of influence, Japan established a protectorate over Korea. Contrary to the expectations of some reformers, Japan did not become a pillar in the modernization of the Korean state, perceiving Korea only as a colony. The involvment of female low-paid labor and the sexual exploitation of Korean women became evidence of the exploitative nature of Japanese colonial policy.
Aquasomes: Advanced Vesicular-based Nanocarrier Systems
Authors: Kulkarni Samruddhi , Prabhakar Bala , Shende Pravin
Published: August 2022

Background:

Aquasomes are novel trilayered non-lipoidal vesicular nanocarriers that demonstrate
structural similarity to ceramic nanoparticles with theranostic activity for diseases like ovarian cancer and
antigen delivery.

Objective:

The objective of the present article is to highlight the multifaceted potential of aquasomes over other
nanocarriers for the treatment of various treatments like hemophilia A, cancer, and hepatitis.

Methods:

Aquasomes enter the target cell by modifying the surface chemistry, extending drug release. The solid
core of aquasomes provides structural stability whereas their oligomeric coatings protect drugs from dehydration.
This vesicular delivery system was successfully utilized for the delivery of acid-labile enzymes,
antigens, vaccines, etc. The aquasomes nanocarrier exhibits a larger surface area, volume, and mass ratio that
allows the drug to penetrate inside the cells and a prolonged drug release profile. Moreover, aquasomes consist
of a high mechanical strength, reduced or no biodegradability during storage, and a good body response that
facilitates deeper penetration into capillaries which makes them more special and interesting.

Results:

Aquasomes are a potential alternative over other nanocarriers for insulin, antigen, and oxygen delivery.

Conclusion:

In the near future, aquasomes-based nano-drug delivery systems can be a fascinating field for research
in nanotechnology.
Pharmacological Targeting of Epithelial-to-Mesenchymal Transition in Colorectal Cancer
Authors: Zafari Nima , Velayati Mahla , Nassiri Mohammadreza , Khazaei Majid , Hassanian Seyed Mahdi , Ferns Gordon A. , Avan Amir
Published: August 2022

Background:

Colorectal cancer (CRC) is the third most common cause of cancer deaths, and metastasis is a major cause of mortalities. The survival rate of patients diagnosed with metastasis remains disappointing. Therefore, the prevention of tumor dissemination as well as treatment of existing metastatic lesions is an important focus of new cancer therapies. Epithelial-to-mesenchymal transition (EMT) is defined as a cellular transition from an epithelial to a mesenchymal state and determines lethal cancer characteristics consisting of invasiveness, metastasis formation, and drug resistance.

Methods:

We reviewed PubMed and EMBASE libraries to collect data about pharmacological targeting of Epithelial- to-Mesenchymal Transition in colorectal cancer to prevent metastatic tumor distribution and improve the survival of patients with CRC.

Result:

We provided an overview of the available EMT-based therapies in CRC, summarized FDA-approved and under-clinical trial drugs with EMT-inhibiting properties in metastatic CRC, and described several agents preventing EMT-associated progression and metastasis in preclinical studies. Although various preclinical and clinical findings have proven that inhibiting EMT via different pharmacological approaches can reduce aggressive features of many cancers, not all agents possessing EMT-inhibiting function in preclinical research exhibit improvement in clinical studies.

Conclusion:

Combating EMT as a therapeutic intervention with the aim of preventing tumor dissemination, eliminating exiting metastasis, and promoting resistance to therapy may be a novel and effective strategy in the treatment of CRC. We hope that further exploration of EMT-related mechanisms and EMT-inhibiting drugs will provide more opportunities to treat CRC efficiently.
Studies on Bloom Energy Server
Authors: Bulushi Faisal Al , A.M. Saravanan , Patil Ganesh , Walke Santosh
Published: August 2022

Background:

Energy is a fundamental requirement in economic growth and is
directly related to almost all aspects of global development. The global energy demand is
increasing daily due to the expanding economy, industrialization, and population growth.
Countries have adopted the trend of renewable energy over non-renewable energy due to
the sustainability of renewable energy sources. Bloom energy server is a renewable energy source that utilizes solid oxide fuel cell (SOFC) technology to convert fuel into electricity through an electrochemical reaction with high efficiency and without combustion.
Oman, however, still relies on non-renewable energy sources, namely oil and gas. Countries continuously apply the most efficient and cost-effective energy sources with the
other different energy sources available

Objective:

This paper aims to investigate the different available energy sources, both renewable and non-renewable and compare them and the bloom energy server and make
conclusions that Oman can adopt

Methods:

The methodology used was a comprehensive literature search of the Google
Scholar database, ProQuest database and Google search. The energy sources investigated
are SOFC, solar power, wind energy, hydropower, crude oil energy, coal energy and natural gas. The variant energy sources were compared based on the following parameters:
capacity capital cost, reliability and availability, sustainability, lifetime, environmental
concerns, efficiency, and long-term cost-effectiveness.

Results:

Results showed that renewable energy sources are superior to non-renewable
energy sources. Of the renewable sources, SOFC was the most reliable, hydropower the
most efficient with the longest lifetime, and solar and wind energy provided a long-term,
cost-effective energy option

Conclusion:

In conclusion, perhaps bloom energy servers are not the best option for
Oman, but the adoption of renewable energy sources is strongly urged