bluuebunny/crossref_metadata_2025 huggingface dataset:
CEREBRAL BLOOD FLOW AND STATE OF SOME COGNITIVE FUNCTIONS IN HEALTHY HUMAN SUBJECTS FOLLOWING 520-DAY ISOLATION
Authors:   Institute of Biomedical Problems of Russian Academy of Sciences, Moscow, Kriushev E.S.
Published: May 2023

Six male volunteers at the age of 27 to 39 years were participants in an investigation of cerebral circulation and cognitive functions in a 520-d isolation study. Transcranial doppler ultrasonography was used for continuous recording the mean linear blood flow velocity in medial cerebral arteries (MCAs) at rest, during voluntary maximal breath-holding (hypercapnia), and cognitive tests. After the long-term isolation, both MCAs retained a statistically significant increase of the standard deviation of blood flow velocity relative to the values at rest. This finding reflects changes in amplitude of blood flow fluctuations in response to physiological and cognitive tests. Cognitive functions and mean blood flow velocity in both MCAs were not affects by long-term isolation.
Research Progress of α-Synuclein Aggregation Inhibitors for Potential
Parkinson’s Disease Treatment
Authors: Kalsoom Iqra , Wang Yuanhao , Li Bo , Wen Hongliang
Published: May 2023

Introduction:

Parkinson’s disease (PD) is characterized by fibrillation of disordered proteins
known as Lewy bodies in the substantia nigra that also undergo progressive neurodegeneration.
The aggregation of α-synuclein (α-syn) is a hallmark and potentially a critical step in the development
of Parkinson’s disease and other synucleinopathies. The synaptic vesicle protein α-syn is a small,
abundant, highly conserved disordered protein and the causative agent of neurodegenerative diseases.
Several novel pharmacologically active compounds are used to treat PD and other neurodegenerative
disorders. Though, the mechanism through which these molecules inhibit the α-syn aggregation is still
not fully understood.

Objective:

This review article is focused on the recent advancements in compounds that can inhibit
the development of α-syn fibrillation and oligomerization.

Methods:

The current review article is based on the most recent and frequently cited papers from
Google Scholar, SciFinder, and Researchgate sources.

Description:

In the progression of PD, the mechanism of α-syn aggregation involves the structural
transformation from monomers into amyloid fibrils. As the accumulation of α-syn in the brain has
been linked to many disorders, the recent search for disease-modifying medications mainly focused on
modifying the α-syn aggregation. This review contains a detailed report of literature findings and illustrates
the unique structural features, structure-activity relationship, and therapeutic potential of the
natural flavonoids in the inhibition of α-syn are also discussed.

Conclusion:

Recently, many naturally occurring molecules such as curcumin, polyphenols, nicotine,
EGCG, and stilbene have been recognized to inhibit the fibrillation and toxicity of α-syn. Therefore,
knowing the α-synuclein filament's structure and how they originate will help invent particular biomarkers
for synucleinopathies and develop reliable and effective mechanism-based therapeutics. We
hope the information this review provides may help evaluate novel chemical compounds, such as α-
syn aggregation inhibitors, and will contribute to developing novel drugs for treating Parkinson’s disease.
Recent Development and Advancement in Quantum Dots in
Pharmaceutical and Biomedical Fields for the Delivery of Drugs
Authors: Singh Pranjal Kumar , Singh Smita , Sachan Kapil , Verma Vikrant , Garg Sakshi
Published: May 2023

Nanoscale semiconductors known as quantum dots (QDs) are essential for drug testing
because they bridge the gap between nanotechnology and the testing of drugs. QDs are a valuable
tool in theranostics and treatment because of their unique physicochemical features. Due to their
photoluminescence and electronic properties, including broad and continuous absorption spectra,
narrow emission spectra from visible to near-infrared wavelengths, and long-lasting and high
brightness, they are suitable probe materials for use in (bio)sensing (immunological) platforms.
Several studies use QDs due to their optical, magnetic, electrical, photochemical, and biological
features that allow them to be employed in various scientific domains. When utilized in drug delivery
systems, fluorescent markers, such as QDs, can track the metabolism of drugs in the human
body. Many medicinal applications, such as disease diagnosis and medication research, can benefit
from these fluorescent tests. In this review article, the application of QD in drug delivery and
immunoassay sensing has been described in detail.
WITHDRAWN: Application of Chemotherapeutic Drugs and Convectionenhanced
Delivery Technology in Glioma
Authors: Huang Jinbai , Wang Wei , Zhou Yishu , Xue Yanfang , Ye Feilong , Wang Licui
Published: May 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has
been withdrawn from the website of the journal Anti-Cancer Agents in Medicinal Chemistry.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
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must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Role and Application of Nanostructures in Biotechnology
Authors: Rani Nidhi , Sharma Prerna , Gangwar Aishwarya , Verma Inderjeet , Walia Aditya
Published: May 2023

Nanotechnology is a major area of research entitling the production of an utmost different class
of materials. There are various types of nanostructures, such as nanoparticles, nanocrystals, nano spores,
nanorods, nanowires, nanoribbons, nanotubes, nano scaffolds, dendrimers, quantum dots, nanospheres,
and nanocapsules. These are size-dependent; thus, altering their size and shape to the nanoscale can alter
their properties. Also, they can be manufactured via various different methods. On a wider scale, in combination,
nanostructured materials and nanotechnology can have profound impacts, including biomedical
applications with advanced research in the delivery of biomolecules, the delivery of drugs, the diagnosis
of cancer, tissue engineering, the detection of biomarkers and imaging. These materials have numerous
applications in fabricating biotechnology, an advanced area of research.
A Photovoltaic-based Novel Transformerless High Gain Converter for DC
Microgrid Applications
Authors: Ramasamy Kannan , Subramani Pragaspathy , Venkitusamy Karthikeyan , Kadali Kalyan Sagar , Sankaranarayanan Saravanan , Ganesh Motepalli Siva Rama
Published: May 2023

Aim:

A typical microgrid network sourced by renewable energy encounters a technical
setback owing to the voltage imbalance across the source integration and load power dissemination.
Transformers employed to stabilize the potential may deteriorate the network efficiency and
increases the cost and size of the system as well.

Introduction:

Photovoltaic based transformerless high gain DC-DC converter (THG-DC) is proposed
here to aid the microgrid infrastructure. Microgrid fuelled by renewable energy sources demands
the high gain converter interface to boost low voltage generation. The proposed THG-DC is
employed with four switched inductors and three active power switches (IGBT) which are brought
together under dual leg configurations.

Methods:

The proposed topology offers dual-duty cycle modes of regulating the active switches to
realize the desired output voltage. Moreover, it is reliable to drive the proposed THG-DC with
lower values of duty cycles to achieve a higher gain. The voltage stress across the switches is minimized
and the magnitude of inductor current ripples is quashed to an extent. The proposed THGDC
is simple in architecture and easy to control in all three operating modes.

Results:

The operating characteristics and performance investigation of the novel converter during
the continuous and discontinuous modes are elucidated briefly and the comparative analysis on
switching stress, gain, and efficiency are executed to justify the standards of the proposed THGDC.

Conclusions:

Finally, the miniature prototype model is experimented with in the laboratory (0.3
kW) and the obtained results are in agreement with the theory. It is evident from the investigations
that the proposed THG-DC shows its dominance over other converters on the voltage gain, switching
stress, number of components, and overall efficiency.
Recent Advances and Trends in ZnO Hybrid Nanostructures
Authors: Kalia R.
Published: May 2023

ZnO nanostructures are excellent candidates for use in the production of functional devices because to their low toxicity, robust thermal stability, excellent corrosion resistance, biocompatibility, high specific surface area, and high conductivity. In this chapter we have discussed the various nanostructures of ZnO and their kind, synthesis of hybrid ZnO nanostructure, modification in nanostructure of ZnO, Hybrid nanostructure of ZnO. In addition, we have discussed the various methods like Sol-gel method, Hydrothermal method and Green Synthesis method in detail for the synthesis of ZnO nanostructures. The effect of these methods on variation of nanostructures have been discussed in detail. It has been observed that because of its great sensitivity to the chemical environment, ZnO nanostructures have been extensively used in sensing applications. Also, the ZnO nano structures have been widely used in light emitting diodes and in solar cells because of its semiconducting nature. The ZnO is a n-type semiconductors and has a perfect bandgap of 3.37eV for its use in solar cell applications. Thus, this chapter provides a detailed discussion about the various nano structures of ZnO, the synthesis methods and various applications.
Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study (Preprint)
Authors: Cao Xingqi , Li Xueqin , Zhang Jingyun , Sun Xiaoyi , Yang Gan , Zhao Yining , Li Shujuan , Hoogendijk Emiel O , Wang Xiaofeng , Zhu Yimin , Allore Heather , Gill Thomas M , Liu Zuyun
Published: May 2023

BACKGROUND

Compared with adults with normal glucose metabolism, those with prediabetes tend to be frail. However, it remains poorly understood whether frailty could identify adults who are most at risk of adverse outcomes related to prediabetes.

OBJECTIVE

We aimed to systematically evaluate the associations between frailty, a simple health indicator, and risks of multiple adverse outcomes including incident type 2 diabetes mellitus (T2DM), diabetes-related microvascular disease, cardiovascular disease (CVD), chronic kidney disease (CKD), eye disease, dementia, depression, and all-cause mortality in late life among middle-aged adults with prediabetes.

METHODS

We evaluated 38,950 adults aged 40 years to 64 years with prediabetes using the baseline survey from the UK Biobank. Frailty was assessed using the frailty phenotype (FP; range 0-5), and participants were grouped into nonfrail (FP=0), prefrail (1≤FP≤2), and frail (FP≥3). Multiple adverse outcomes (ie, T2DM, diabetes-related microvascular disease, CVD, CKD, eye disease, dementia, depression, and all-cause mortality) were ascertained during a median follow-up of 12 years. Cox proportional hazards regression models were used to estimate the associations. Several sensitivity analyses were performed to test the robustness of the results.

RESULTS

At baseline, 49.1% (19,122/38,950) and 5.9% (2289/38,950) of adults with prediabetes were identified as prefrail and frail, respectively. Both prefrailty and frailty were associated with higher risks of multiple adverse outcomes in adults with prediabetes (P for trend <.001). For instance, compared with their nonfrail counterparts, frail participants with prediabetes had a significantly higher risk (P<.001) of T2DM (hazard ratio [HR]=1.73, 95% CI 1.55-1.92), diabetes-related microvascular disease (HR=1.89, 95% CI 1.64-2.18), CVD (HR=1.66, 95% CI 1.44-1.91), CKD (HR=1.76, 95% CI 1.45-2.13), eye disease (HR=1.31, 95% CI 1.14-1.51), dementia (HR=2.03, 95% CI 1.33-3.09), depression (HR=3.01, 95% CI 2.47-3.67), and all-cause mortality (HR=1.81, 95% CI 1.51-2.16) in the multivariable-adjusted models. Furthermore, with each 1-point increase in FP score, the risk of these adverse outcomes increased by 10% to 42%. Robust results were generally observed in sensitivity analyses.

CONCLUSIONS

In UK Biobank participants with prediabetes, both prefrailty and frailty are significantly associated with higher risks of multiple adverse outcomes, including T2DM, diabetes-related diseases, and all-cause mortality. Our findings suggest that frailty assessment should be incorporated into routine care for middle-aged adults with prediabetes, to improve the allocation of health care resources and reduce diabetes-related burden.
Prediction of Diabetes Using Machine Learning and Data Mining Algorithm (Preprint)
Authors: Shojaee-Mend ⦁	Hassan , Velayati Farnia , Tayefi Batool , Babaee Ebrahim
Published: May 2023

BACKGROUND

Introduction: Currently, diabetes is known as one of the major health problems and the most important issue in the medical profession which has a high prevalence in children and adults. On the other hand, machine learning has been introduced as a developing, reliable, and supportive technology in the field of health, and one of the interesting techniques for analyzing interventions, diseases, and conditions of the health system is the use of data mining. In fact, data mining is the process of selecting, exploring, and modeling large amounts of data.

OBJECTIVE

The present study was performed in order to predict fasting blood sugar status using machine learning and data mining.

METHODS

The data used in this study was from a diabetes screening program in Tehran. 3376 participants over 30 years old in 16 comprehensive health service centers participated in this screening program to check the prevalence of diabetes and its related risk factors. The dataset was not balanced according to the output variable. Therefore, the random sampling method and SMOTE technique were used for making a balance. Four different machine learning algorithms including CatBoost, Random Forest, XGBoost, and logistic regression were used to model the dataset. Also, the Shapley technique was used to select the most important features. Accuracy, sensitivity, specificity, accuracy, F1- Score, and AUC criteria were used to evaluate the model.

RESULTS

The results of the Shapely technique in selecting the most important features showed that the characteristics of age, waist-to-hip ratio, body mass index, and systolic blood pressure were the most important factors in predicting fasting blood sugar status. Also, the modeling results showed that the CatBoost algorithm gave the best results. For the CatBoost algorithm, various evaluation criteria including accuracy, sensitivity, specificity, and AUC were obtained as 65.98%, 71.32%, 64.54%, and 0.74% respectively.

CONCLUSIONS

In this study, a predictive model was developed using gradient-improved decision tree algorithms to identify the most important risk factors related to diabetes. Age, waist-to-hip ratio, body mass index, and systolic blood pressure were the most important risk factors for diabetes, respectively. This model can be used in the planning for diabetes management.
Technology Acceptance of a Social Robot (LOVOT) Among Single Older Adults in Hong Kong and Singapore: Protocol for a Multimethod Study (Preprint)
Authors: Tan Cheng Kian Kelvin , Lou Vivian W Q , Cheng Clio Yuen Man , He Phoebe Chu , Mor Yan Ying
Published: May 2023

BACKGROUND

Given the rapidly aging nature of our global population, policy makers around the world are now emphatically promoting active aging. To address the psychosocial needs of older persons and support active aging, researchers are exploring the use of assistive technologies, specifically social robots as companions. However, there is limited evidence on the efficacy of social robots in promoting active aging for older people in the Hong Kong and Singapore contexts.

OBJECTIVE

This study presents the protocol of a study that investigates the acceptance and quality of interaction between a Japanese social robot, LOVOT, and single older adults in Hong Kong and Singapore.

METHODS

We used a baseline assessment to measure the primary outcome, participants’ acceptance of technology, and a sense of loneliness, namely, the participants’ differences in responses to LOVOT before and following their interaction with the social robot in this multimethod study design. The baseline assessment consisted of the Qualtrics survey, which measures senior technology acceptance, loneliness, older people’s quality of life, subjective happiness, cultural values, willingness to pay, and demographic characteristics, along with the LOVOT’s sociability and system usability. In the study, participants interacted with LOVOT in 3 sessions before being surveyed to measure the older people’s acceptance and attitudes toward LOVOT. A pre–social robot intervention also occurred in the first session. The study was conducted in both Hong Kong and Singapore. A total of 15 single older adults (ie, individuals who live alone) from Hong Kong and another 15 from Singapore were recruited. Participants were 60-75 years of age, lived by themselves, and had no known cognitive or mental issues.

RESULTS

The study began recruiting in March 2022, and recruitment was completed at the end of October 2022. Data collection and data set construction were completed at the end of January 2023. Analysis of the data is currently being conducted, and we plan to publish the results by mid-2023.

CONCLUSIONS

At an individual level, the study will clarify if LOVOT influences single older adults’ psychosocial well-being by reducing their loneliness. At a community level, the study’s findings will illustrate whether LOVOT can provide increased social connectedness while decreasing individual loneliness. Last, this study’s conclusions can inform policy makers to provide social robots to older people to improve their quality of life. Findings can also inform gerontechnology developers on which aspects and cultural considerations to take into account for future inventions.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/48618
Parental Interventions and Implementing Model for Tackling Misuse of Digital Media among the Teenagers in Bangladesh: A Qualitative Exploration (Preprint)
Authors: BakiBillah Abul Hasan , Khan Ayub , Muhammad Faisal , Sultana Sharmin , Shahinuzzaman Md. , Akram Muhammad , Almasri Nihad A. , Wani Mohammad Amin , Hossain Syed Billal , Ghosh Sanchita , Mukherjee Anindita , Kabir Russell , Chowdhury ABM Alauddin , Chowdhury Moniruddin
Published: May 2023

BACKGROUND

In Bangladesh, parents are crucial in ensuring that teens use digital devices responsibly.

OBJECTIVE

The purpose of this study was to figure out the parental interventions along with the implementing model in order to tackle the misuse of digital media among teenagers.

METHODS

Nineteen key informants took part in this study as part of the qualitative inquiry.

RESULTS

Participants come from a variety of backgrounds and play a variety of roles that all support the same goal. The parenting model was created using the information from the interviews. By placing secondary and upper secondary educational institutions at the core of government action, parents will be educated. This approach was first proposed to be used in the "Generation Breakthrough" program of the Ministry of Education. Parents should be invited to the institutions to learn about the actions that need to be performed and followed under the two main categories, preventative and curative. Technology, the spoken word, psychology, and relationships built on evidence and trust are all examples of preventive approaches. Corrective measures include counseling, assistance with cyber security, legal services, and law enforcement.

CONCLUSIONS

In order to ensure that teens are using digital devices responsibly, this study suggests educating and empowering parents through viable strategies.
Correction: iCHECK-DH: Guidelines and Checklist for the Reporting on Digital Health Implementations (Preprint)
Authors: Perrin Franck Caroline , Babington-Ashaye Awa , Dietrich Damien , Bediang Georges , Veltsos Philippe , Gupta Pramendra Prasad , Juech Claudia , Kadam Rigveda , Collin Maxime , Setian Lucy , Serrano Pons Jordi , Kwankam S Yunkap , Garrette Béatrice , Barbe Solenne , Bagayoko Cheick Oumar , Mehl Garrett , Lovis Christian , Geissbuhler Antoine
Published: May 2023

UNSTRUCTURED
Examining the Effectiveness of Electronic Patient-Reported Outcomes in People With Cancer: Systematic Review and Meta-Analysis (Preprint)
Authors: Perry Melissa Betty , Taylor Sally , Khatoon Binish , Vercell Amy , Faivre-Finn Corinne , Velikova Galina , Marsden Antonia , Heal Calvin , Yorke Janelle
Published: May 2023

BACKGROUND

Electronic patient-reported outcomes (ePROs) are commonly used in oncology clinical practice and have shown benefits for patients and health resource use.

OBJECTIVE

The aim of this study was to compare the isolated effect of administering ePROs to patients with cancer versus a control condition.

METHODS

The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed. Randomized controlled trials evaluating ePRO interventions that aimed to improve health-related outcomes among patients with cancer were included. The primary outcome was health-related quality of life (HRQOL), and the secondary outcomes were symptoms, hospital admissions, unplanned visits, chemotherapy completion, survival, and satisfaction with care. The effect sizes of ePROs on health-related outcomes were analyzed as standardized mean differences (SMDs) with 95% CIs using a random effects model.

RESULTS

The search identified 10,965 papers, of which 19 (0.17%) from 15 studies were included. The meta-analysis showed an improvement in HRQOL at 3 months, measured by the Functional Assessment of Cancer Therapy–General (SMD 0.28, 95% CI –1.22 to 1.78), and at 6 months, assessed using various HRQOL measures (SMD 0.07, 95% CI –1.24 to 1.39). The results should be interpreted with caution, given the wide 95% CIs. Of the 15 studies, 9 (60%) reported a positive signal on HRQOL, with two-thirds of the studies (n=6, 67%) including tailored patient advice and two-thirds (n=6, 67%) using clinician alert systems.

CONCLUSIONS

The meta-analysis showed a potential improvement in HRQOL at 6 months and in Functional Assessment of Cancer Therapy–General scores at 3 months for studies that included tailored advice and clinician alerts, suggesting that these elements may improve ePRO effectiveness. The findings will provide guidance for future use and help health care professionals choose the most suitable ePRO features for their patients.

CLINICALTRIAL

PROSPERO CRD42020175007; https://tinyurl.com/5cwmy3j6
Звернення головного редактора
Authors: Sirenko Yu.M.
Published: May 2023

No abstract
Прихильність до терапії у хворих високого серцево-судинного ризику в Україні: пацієнт-орієнтовані причини і можливості її поліпшення
Authors: Sirenko Yu.M. , Rekovets O.L.
Published: May 2023

Актуальність. Прихильність до лікування факторів ризику (антигіпертензивної, ліпідознижуючої та антитромботичної терапії, лікування діабету) не тільки запобігає прогресуванню захворювання, але й зменшує смертність від серцево-судинних причин. У цій статті ми проаналізували результати всеукраїнського дослідження думки пацієнта, проведеного методом інтерв’ювання хворих, щодо важливості поінформованості пацієнтів відносно серцево-судинних захворювань (ССЗ), алгоритму звернення пацієнтів до лікаря і дотримання призначеного режиму лікування для запобігання майбутнім ускладненням. Матеріали та методи. Дослідження виконано на основі глибинного інтерв’ю (приблизно 75 хв), яке було проведено у 12 досвідчених хронічних хворих на серцево-судинну патологію (із клінічно доведеним атеросклерозом і його ускладненнями та супутнім цукровим діабетом 2-го типу в частки з них) обох статей з різних регіонів України. Інтерв’ю записувались і аналізувалися спеціалістами, для яких українська мова є рідною, отже, не могло бути мовного бар’єра при його проведенні й оцінці результатів. Результати. Основний результат опитування показав необхідність збільшення поінформованості пацієнтів щодо симптомів захворювання. Це зумовлено високою часткою опитаних хворих, які були абсолютно не інформовані відносно симптомів ССЗ до встановлення діагнозу, а це може привести до затримки звернення по медичну допомогу, відстрочення встановлення діагнозу й раннього початку лікування. Наше опитування показало також низьке залучення пацієнтів до моніторингу їх симптомів. Це може асоціюватися з низькою прихильністю до терапії внаслідок неадекватної оцінки свого стану, а також неадекватного контролю симптомів при лікуванні. Відповіді респондентів показали, що найбільш зручним і критичним періодом, від якого залежить майбутня прихильність до лікування, є період з початку встановлення діагнозу й призначення лікування (перші 1–3 місяці), коли пацієнти відчувають себе найбільш вразливими і найбільше довіряють лікарю. Висновки. Використання методів моніторування свого стану, таких як фіксовані щоденники (надані лікарем) або електронні додатки, програми для смартфонів або планшетів, можуть допомогти пацієнтам стежити за симптомами, активно контактувати із лікарем при необхідності корекції лікування або загостренні. І ще наше опитування висвітлило необхідність навчання пацієнта щодо розуміння суті його хвороби і, отже, його залучення до лікування й поліпшення співпраці з медичним персоналом.
Каротидний атеросклероз і Н-тип артеріальної гіпертензії
Authors: Rekovets O.L. , Sirenko Yu.M. , Torbas O.O. , Kushnir S.M. , Primak G.F.
Published: May 2023

Актуальність. Атеросклеротичне ураження сонних артерій є важливим фактором ризику серцево-судинних захворювань. Останнім часом все більше доказів того, що артеріальна гіпертензія (АГ) зустрічається в поєднанні з гіпергомоцистеїнемією (ГГЦ) і може бути виявлена одночасно з бляшками в сонних артеріях, що впливає на прогноз подальших серцево-судинних подій. Мета: визначення зв’язку атеросклеротичного ураження каротидних артерій з наявністю артеріальної гіпертензії та гіпергомоцистеїнемії. Матеріали та методи. Наше дослідження було виконано в рамках дослідження ХІПСТЕР в Україні. У дослідження було включено 40 пацієнтів з I і II ступенем АГ (середній рівень офісного систолічного (САТ) і діастолічного артеріального тиску (ДАТ) — 155,88 ± 1,63 мм рт.ст. і 92,60 ± 1,43мм рт.ст. відповідно). Середній вік хворих становив 55,85 ± 2,09 (26–74) року. Пацієнтів з рівнем гомоцистеїну ≥ 10 мкмоль/л визначали як пацієнтів із ГГЦ (Н-тип АГ). Жорсткість судин визначали за швидкістю поширення пульсової хвилі (ШППХ). Пацієнтам проводили дослідження на початку і через 6 місяців лікування. Визначення наявності атеросклерозу каротидних артерій проводили на початку і через 12 місяців спостереження. Результати. Нами виявлено, що oфісний САТ у пацієнтів з Н-типом АГ на початку і через 6 місяців лікування був вищим порівняно з пацієнтами без ГГЦ (156,45 ± 1,04 мм рт.ст. проти 152,55±1,41мм рт.ст. на початку (р < 0,05) і 130,65 ± 0,96 мм рт.ст. проти 126,97 ± 1,08 мм рт.ст. через 6 місяців (р < 0,05)). Пацієнти з Н-типом АГ порівняно з пацієнтами без ГГЦ мали більш виражений ступінь інсулінорезистентності (індекс НОМА 4,27 ± 0,18 ум.од. проти 3,20±0,24 ум.од., р< 0,05). Атеросклеротичні бляшки в сонних артеріях було виявлено в 56,7 % (n = 17) пацієнтів із Н-типом АГ і 40,0 % (n = 4) пацієнтів з АГ без ГГЦ (p < 0,05 між групами). Пацієнти з Н-типом АГ мали більшу поширеність каротидного атеросклерозу — площа атеросклеротичної бляшки, виміряна за NASCET, становила 43,4 % проти 26,7 % (p < 0,05) і була більшою, ніж у пацієнтів з АГ без ГГЦ. Нові атеросклеротичні бляшки через 12 місяців було виявлено в 3 пацієнтів (10,0 %) із Н-типом АГ і не було виявлено в жодного пацієнта з групи АГ без ГГЦ. При проведенні регресійного аналізу рівень гомоцистеїну в сироватці крові асоціювався з ШППХ незалежно від зниження артеріального тиску на фоні терапії, а також із рівнем холестерину ліпопротеїдів низької щільності й наявністю атеросклеротичних бляшок у сонних артеріях. Гомоцистеїн був пов’язаний із ШППХ артеріями еластичного типу після лікування (β = 0,307; Р = 0,001), холестерином ліпопротеїдів низької щільності до лікування (β = –1,501; Р = 0,017), наявністю атеросклеротичних бляшок після лікування (β =5,236; Р= 0,031). Висновки. Атеросклеротичне ураження сонних артерій було пов’язане з Н-типом артеріальної гіпертензії.
«Salimos porque nos quisieron matar». Refugio guatemalteco en Chiapas, 1981-1999
Authors: Pérez Mendoza Joel
Published: May 2023

Quienes han estudiado el tema del refugio guatemalteco en México se han concentrado principalmente en las causas que lo propiciaron, en la aplicación de algunos programas de salud y educación, en los procesos de retorno e integración que trajeron consigo la resignificación o la construcción de nuevas identidades y en la lucha por su aceptación como nuevos mexicanos y mexicanas o por reintegrarse a su país de origen. Sin embargo, pocas han sido las que han tratado de hacer una reconstrucción histórica del proceso de refugio en México, que es precisamente el objetivo de esta obra. En este sentido, se pone especial atención en la vida cotidiana en los campamentos de refugio así como en su relación con la población chiapaneca, la diócesis de San Cristóbal de Las Casas, las autoridades mexicanas y las organizaciones guerrilleras guatemaltecas.
BEYOND MYTHS: REDISCOVERY OF THE WESTERN DIAMONDBACK RATTLESNAKE Crotalus atrox (BAIRD & GIRARD, 1853) IN THE MEXICAN STATE OF OAXACA AFTER A SPAN OF 79 YEARS
Authors: Villalobos Juárez Ivan , García- Padilla Elí , Ayala-Auyón Javier , Mayoral-Halla Cesar , Aguilar-Terrazas J. Carmen
Published: May 2023

We rediscovered and confirmed, after a span of 79 years, the presence of the Western Diamondback Rattlesnake Crotalus atrox in the Mexican state of Oaxaca. The record is based on six specimens found in an anthropized environment within the Base Aérea Militar II located in Ciudad Ixtepec, in the municipality of Asunción Ixtaltepec within the Isthmus of Tehuantepec region.
Las mitocondrias: sus funciones, las relaciones con otros organelos, la supervivencia celular y la medicina mitocondrial
Authors: Olvera-Sánchez Sofía , Gómez-Chang Erika , Flores-Herrera Oscar , Martínez Federico
Published: May 2023

Durante años se consideró que la función más importante de las mitocondrias era la de proveer a la célula de energía en forma de ATP o incluso, fungir como amortiguadores de la concentración del calcio citosólico. Sin embargo, se ha demostrado que las mitocondrias tienen más atributos al ser una parte medular de las cascadas de señalización, y de compartir funciones con las estructuras intra y extracelulares que permiten mantener la homeostasis y la función celular. Además, hay reportes que muestran que las células sanas pueden transferir a las mitocondrias por el torrente circulatorio o directamente a las células dañadas con el objetivo de brindarles protección y mejorar su función bioenergética en condiciones específicas. Los mecanismos de señalización para el reconocimiento de moléculas marcadoras son determinantes para establecer la transferencia de las mitocondrias entre células y a través de las estructuras vesiculares o de los túneles (TNT), entre otros sistemas. Actualmente, se han desarrollado estrategias para el aislamiento de las mitocondrias, las cuales, a su vez, se inyectan en los tejidos permitiéndoles su recuperación funcional, a lo que se ha llamado la “medicina mitocondrial” o la “mitocuración”. Aunque estos hallazgos sugieren que las mitocondrias podrían ser un nuevo método de profilaxis para las enfermedades o trastornos metabólicos, es necesario considerar que la transferencia mitocondrial no es del todo una solución positiva en el tratamiento de algunos padecimientos.
Análisis proximal, actividad antimicrobiana y crecimiento in vitro de Podaxis pistillaris s.l.
Authors: Quiñónez-Martínez Miroslava , Martínez-Escobedo Neida Aurora , Nájera-Medellín Jesús Alejandro , Valero Galván José , Garza-Ocañas Fortunato
Published: May 2023

Podaxis pistillaris s.l. (sensu lato) es un hongo gasteroide distribuido en las regiones áridas y semiáridas del mundo. Es usado en la medicina tradicional para tratar los problemas dermatológicos, como alimento y con fines estéticos por algunas tribus indígenas, sin embargo, el conocimiento sobre su composición proximal y potencial antibacterial es escaso en la literatura. En el presente estudio se determinó la composición proximal, así como la actividad antimicrobiana en Streptococcus agalactiae y Candida albicans a través del método de difusión en disco y Concentración Mínima Inhibitoria (CMI); el crecimiento miceliar in vitro en cinco medios de cultivo y tres pH distintos para el crecimiento de P. pistillaris. Los resultados muestran que el carpóforo de la especie es rico en proteínas (15.2%) y en carbohidratos (27.8%) y con bajo contenido lipídico (0.5%). Además, el crecimiento en ambos organismos se inhibió con la técnica de CMI a una concentración de 8.75 mg/mL para C. albicans y 6.25 mg/mL para S. agalactiae. Se obtuvo mejor crecimiento micelial in vitro al usar Agar de Maíz y de Avena en un pH de 7.0. Esta investigación reporta el primer estudio proximal y antimicrobiano de una especie con potencial médico-alimenticio del norte del desierto Chihuahuense.
Explanatory Problems for Mass Additivity and Dynamics
Authors: Perry Zee R.
Published: May 2023

I present an argument against the view that the additivity of mass (i.e., the property according to which a composite object’s mass is the “sum” of its parts’) is metaphysically independent of dynamical laws governing massive bodies. In particular, taking additivity to be independent of dynamics commits you to widespread unexplained correlations between the mass properties of composites and the dynamic behavior of massive bodies. The second half of the paper extends this explanatory worry, showing that the very same considerations apply to aspects of mass’s quantitative structure. This gives rise to a new and powerful objection to certain influential theories about the fundamental structure of physical quantities —most notably the magnitude realism of Peacocke (2019) and the second-order absolutist accounts defended by Mundy (1987) and Eddon (2013b).
Icons, Magnitudes, and Their Parts
Authors: Maley Corey J.
Published: May 2023

Analog representations come in different types. One distinction is between those representations that have parts that are themselves representations and those that do not (i.e., those for which the Parts Principle is true and those for which it is not). I offer a unified account of analog representation, showing what all types have in common. This account clarifies when the Parts Principle applies and when it does not, thereby illuminating why the Parts Principle is less interesting than one might have thought. Understanding analog representation instead requires understanding the kinds of magnitudes used in a particular representation, and the kinds of variation possible within a representational scheme.
Parámetro de regularidad constitucional: 10 años de la reforma constitucional en derechos humanos. Implicaciones teóricas y limitaciones prácticas
Authors: Mata Miranda Armando Ramón
Published: May 2023

Han transcurrido diez años de aquella paradigmática reforma constitucional en derechos humanos, la cual derivó en una gran diversidad de consecuencias interpretativas, constitucionales y normativas; entre ellas se conformó una égida protectora de derechos humanos: el parámetro de regularidad constitucional. En contraste, otro aspecto de este legado nos remite necesariamente a la sentencia Varios 293/2011, fallo en el cual se privilegió el aspecto restrictivo a los derechos humanos, cuando la Constitución así lo determine, frente a una protección más amplia dispuesta en los tratados internacionales. Una peculiaridad propia del complejo entramado constitucional, lo que implica algunos aspectos teóricos y ciertas limitaciones prácticas que merecen ser analizadas, y que en el desarrollo del presente trabajo pretendemos dilucidar.
El derecho a la educación en Brasil: diálogo multinivel y las amenazas internas
Authors: Santano Ana Claudia
Published: May 2023

El derecho a la educación es reconocido como un derecho social vital al desarrollo humano. Debido a su importancia, se encuentra expresamente mencionado en los documentos internacionales de protección de los derechos humanos, así como en diversas Constituciones, como es el caso de la brasileña. Además, su análisis ya consta en la jurisprudencia del sistema interamericano de derechos humanos, dándoles fuerza y sindicabilidad. Sin embargo, en los últimos tiempos, distintos aspectos del derecho a la educación están siendo amenazados, lo que hace que, internamente, Brasil se encuentre en una situación de desajuste con la normativa internacional. Partiendo de este contexto de la aún pendiente concreción de estos derechos, este trabajo se propone evaluar la situación del derecho a la educación a partir de una comparación con fallos tanto en el sistema interamericano como en Brasil, verificando si hay, efectivamente, un diálogo entre cortes o si hay, por parte de Brasil, una recepción de la normativa internacional sobre el tema en el ámbito interno. El texto expone algunos casos en los que los ataques a la educación en Brasil pone al país en situación de alerta en el sistema interamericano. Como conclusiones, fue posible observar que la legislación brasileña está de acuerdo con el reglamento internacional, más allá de los estándares mínimos establecidos, aunque este diálogo normativo no está siendo capaz de proteger a este derecho de los ataques del gobierno Bolsonaro.
Anaerobic Profile of Intra-abdominal Infections – A 23-Year Retrospective Study
Authors: Chetty Meghna , Rakhi Biswas , Sujatha Sistla , Chandra Sistla Sarath
Published: May 2023

Obligate anaerobes, which are part of normal intestinal flora are now gaining pathogenic potential by becoming more virulent and causing moderate to severe abdominal infections. Moreover, there is delay in initiation of appropriate antimicrobial therapy. The study aimed to describe and analyse 23 years data on anaerobic intra – abdominal infections in regards to the distribution and antimicrobial susceptibility patterns of the obligate anaerobes which were isolated from various intra – abdominal infections. The demographic and microbiological data was retrieved from the microbiology departmental registers. Total number of cases/specimen were 1124. Bacteroides fragilis group (238) (56%) and Peptostreptococcus sp (109) (25%) amounted to the majority of the isolates. Rare anaerobes like Clostridium sporogenes, Propionibacterium sp, Clostridium bifermentans and Fusobacterium varium were also isolated. Majority of mixed anaerobic infections were contributed by Bacteroides fragilis group and Peptostreptococcus sp (99) out of 102 mixed anaerobic infections). Chronic alcoholism was the most common predisposing condition (p value <0.05). Among the antimicrobials which were used by the clinicians for treating the infection, only Metronidazole was tested for its susceptibility pattern. One isolate was resistant to metronidazole (Diameter of inhibition zone was 6 mm). As they are fastidious they usually go unnoticed. Hence, this descriptive study intends to bring light on the large number of various obligate anaerobes and the potential diseases that they can cause and also the need for their antibiotic susceptibility testing to look for antimicrobial resistance among the isolates.
CNN LSTM Hybrid Approach for Sentiment Analysis
Authors: Jain Mansi , Vashishtha Purvit , Satyam Aman , Sehgal Smriti
Published: May 2023

Abstract: In recent years, one of the most popular study subjects has been sentiment analysis. It is employed to ascertain the text's actual intention. It is primarily interested in the processing and analysis of natural language data. The development of technology and the phenomenal rise of social media have produced a vast volume of confusing textual information. It's critical to examine the feelings that underlie such writings. Sentiment analysis reveals the core of irrational beliefs kept in enormous volumes of text. The primary objective is to get the computer to comprehend the backdrop of the data so that it may be divided into material that is good or bad. (i) Several machine learning models, including Naive Bayes, XGboost, Random Forest, LGB Machine, etc., are trained in this study. (ii) The implementation of the deep learning model Bi-LSTM, whose accuracy has showed promise. (iii) Bidirectional Encoder Representations from Transformers (BERT), a pre-trained language model that used an external Bi-LSTM model, was implemented. Then, a new approach of CNN-LSTM hybrid model is applied to IMDb dataset which performed better than all the models.
Air Conditioning Heat load Analysis of a Cabin
Authors: Pawar Sharad , Mamulkar Chetan , Kamane Prajakta , Shelki Shubham , Dighore Priya , Singh Ashwin
Published: May 2023

Abstract: Air conditioning, often abbreviated as A/C (US), AC (US), or air con (UK), is the process of removing heat from an enclosed space to achieve a more comfortable interior environment (sometimes referred to as "comfort cooling") and in some cases also strictly controlling the humidity of internal air. Air conditioning can be achieved using a mechanical 'air conditioner' or alternatively a variety of other methods, including passive cooling or ventilative cooling. Air conditioning is a member of a family of systems and techniques that provide heating, ventilation, and air conditioning (HVAC). Heat pumps are similar in many ways to air conditioners, but use a reversing valve to allow them to heat and also cool an enclosed space. Air conditioners, which typically use vapor-compression refrigeration, range in size from small units used within vehicles or single rooms to massive units that can cool large buildings. Air source heat pumps, which can be used for heating as well as cooling, are becoming increasingly common in cooler climates. According to the International Energy Agency (IEA), as of 2018, 1.6 billion air conditioning units were installed, which accounted for an estimated 20% of electricity usage in buildings globally with the number expected to grow to 5.6 billion by 2050. The United Nations called for the technology to be made more sustainable to mitigate climate change and for the use of alternatives, like passive cooling, evaporative cooling, selective shading, windcatchers, and better thermal insulation. CFC and HCFC refrigerants such as R-12 and R-22, respectively, used within air conditioners have caused damage to the ozone layer, and HFC refrigerants such as R-410a and R-404a, which were designed to replace CFCs and HCFCs, are instead exacerbating climate change. Both issues happen due to the venting of refrigerant to the atmosphere, such as during repairs. HFO refrigerants, used in some if not most new equipment, solve both issues with an ozone damage potential (ODP) of zero and a much lower global warming potential (GWP) in the single or double digits vs. the three or four digits of HFCs.
Helmet and License Plate Detection
Authors: Singh Siddhartha , Mishra Padmini , Ojha Siddhartha , Shoaib Mohd , Kumar Shivendra , Yadav Vivek Kumar
Published: May 2023

Abstract: Traffic accidents are one of the leading causes of death today. Motorcycle accidents lead to serious injuries. A helmet is important for every motorcyclist. However, many do not adhere to helmet laws. This is the software CNN uses to find motorcyclists without helmets. The structure consists of motorcycle detection, helmetless classification, and motorcycle licence plate recognition. The motorcycle is scanned with the feature vector HOG. Once the motorcycle is recognised by CNN, do motorcyclists wear helmets? Motorcycle licence plate if it is determined that the motorcyclist is not wearing a helmet. Motorcycles are recognised by Tesseract OCR.
Experimental Investigation on Desert Cooler Using Different Cooling Pad Materials
Authors: Bhagat Prof. P. R. , Rambhad Aakash R. , Barahate Kaushik B. , Raut Abhishek D. , Bhivgade Aman A. , Kusma Abhishek
Published: May 2023

Abstract: Desert coolers are important in society, especially in arid regions with hot and dry climates. They provide a costeffective and energy-efficient alternative to air conditioners, which can be expensive to operate and maintain. Desert coolers use natural cooling mechanisms such as evaporation to cool the surrounding air, which makes them more environmentally friendly than air conditioners. In this case, the cooling materials being considered are coconut coir, wood wool, and honeycomb mesh. This involves constructing a desert cooler with a removable cooling pad compartment to allow for the insertion and removal of the different cooling materials. Install each of the cooling materials in the cooler one at a time and record the temperature and humidity of the air passing through the cooler over a set period of time. Compare the results obtained from each of the cooling materials to determine which one provides the most effective cooling. Honeycomb has been found to have excellent water absorption and retention capacity, which helps in maintaining a high level of humidity in the air passing through the cooler, resulting in better cooling. Honeycomb mesh, on the other hand, has a large surface area and a complex structure that enhances the evaporation process and improves the cooling efficiency. While wood wool is also a popular cooling material used in desert coolers, its efficiency may not be as high as coconut coir or honeycomb mesh. However, the choice of the most efficient cooling material can also depend on other factors such as availability, cost, and environmental impact. Overall, the selection of the most efficient cooling material for a desert cooler may require careful consideration of several factors.
The case study on exploring psychological burnout experience of working women through app-based on-line counseling
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kang Min Sun , Koo Mee-hyang , Lee Jeong-Mi
Published: May 2023

Objectives The aim of this case study is to understand burnout status and examine changes in emotional status using a web-based application with online counseling in working women.
Methods Two participants who have experienced physical and emotional difficulties and been working in an office were included in this case study and asked to choose pre-selected symbolic images and express their emotional status in writing notes using the web-based application.
Results Based on the analysis of personal note, selected images and online counselling, burnout status was expressed as ‘Exhaustion’, ‘Lethargy’, ‘Physical symptoms’, ‘Anxiety’, ‘Conflict confrontation’, ‘Incompetence’, ‘Cynical’, ‘Insensitivity’, ‘Incompetence’, ‘Expectation’, ‘positive expectation’, ‘willingness to try’, ‘hope’, ‘self-confidence’, ‘recovery of trust’.
Conclusions Online counselling using this web-based application is a feasible and acceptable method of understanding and addressing burnout for working women.