bluuebunny/crossref_metadata_2025 huggingface dataset:
Biopharmaceutical innovative ecosystems: problems of legal regulation
Authors: Sushkova O. V.
Published: September 2023

The purpose of this article is to study biopharmaceutical innovation ecosystems through the prism of the results of intellectual activity and objects of civil and business turnover. In doing so, this work aims to answer the following research question: which stakeholders are needed for innovation systems in the biopharmaceutical industry and what is their main role in creating intellectual property. The research strategy was developed in accordance with the grounded theory methodology. The author makes an attempt to prove that biopharmaceutical innovation ecosystems consist of a multi-level set of key stakeholders. In addition, taking a holistic view of biopharma innovation ecosystems, the study traces the dynamics of biopharma innovation ecosystems through a driving force analysis. This article presents an attempt to deeply analyze biopharmaceutical innovation ecosystems from a holistic perspective, including regulatory issues. The conclusions made in the article can be considered an important addition to biopharmaceutical innovations around the world.
History of development of legal regulation of biomedical research
Authors: Gromova A. A.
Published: September 2023

This article analyzes the historical development of medical experiments and biomedical research, as well as their subsequent regulatory consolidation. Medical experiments originate from the I century BC, gradually transforming into biomedical research, taking into account the progressive development of science and the emergence of new and emerging technologies. The article presents various stages of legal regulation of research both in the Russian Federation and abroad. Much attention is paid to the legal regulation of genomic research as a modern type of biomedical research. The author comes to the conclusion that the legal regulation of medical experiments and biomedical research has a long history, however, at the present stage, legislation mainly regulates certain areas, and there is also no general regulatory approach to the achievements of modern biomedical technologies.
Retos del nuevo anteproyecto de Ley asturiana de la infancia. Conferencia inaugural del máster en protección jurídica de las personas y los grupos vulnerables (14 de septiembre de 2022)
Authors: Aláez Corral Benito
Published: September 2023

Sin resumen
El papel del registro de la propiedad en las principales actuaciones urbanísticas
Authors: Vallejo Menéndez Mar
Published: September 2023

El objeto del presente trabajo es analizar la relación entre el RP y las principales actuaciones de ejecución urbanística que pueden acceder a él. En una primera fase nos centraremos en las actuaciones de reparcelación y en los procedimientos de equidistribución, que se insertan en las primeras pese a tener una sustantividad propia y poder encuadrarse en otras actuaciones que se encuentran fuera del ámbito de este trabajo. Posteriormente se analizarán las actuaciones de conservación y rehabilitación. El enfoque adoptado en este trabajo es un análisis de la normativa vigente en la materia, combinando los ámbitos civil y administrativo a nivel estatal y autonómico, centrando este último en el ámbito de la Comunidad Autónoma del Principado de Asturias. Además de lo anterior, también se analizará la doctrina y jurisprudencia existentes en la materia.
Entrevista a D. José Antonio Seijas Quintana, realizada por María Paz Fernández-Rivera González, profesora de Derecho Eclesiástico y Magistrada Suplente de la Audiencia Provincial de Oviedo
Authors: Fernández-Rivera González María Paz
Published: September 2023

Sin resumen
Unresolved pain in a middle-aged woman: an integrated family medicine approach
Authors: KÜÇÜKERDEM Halime Seda , İŞ Olgu , GOKDEMIR Ozden
Published: September 2023

47 years old woman had applied to the outpatient clinic as she was suspicious because of COVID-19. The patient has non-specific symptoms such as fever, pain, and anosmia. The family physician has prescribed Enfluvir, vitamin D, etol-fort tb . After the medication, she has come to the clinic again because of the not finished pain. The family physician that the first one consulted has ordered Magnetic Resonance Imagining for the sacroiliac region as the patient told that the pain when she was sitting for at least two and half years and nowadays her pain was more although she was taking her painkillers. According to the non-contrast, MRI of the sacroiliac joint: “ joint surfaces exhibit irregularity and narrowing. In the posterior, more prominent articular surfaces on the right in the fat-suppressed axial and coronary sequences, there is focal bone marrow edema and sacroiliitis activation. The right adnexa within the sections showed an 8 cm cystic appearance. MRI and USG of the lower abdomen are advised.”. The lab and also with IV contrast, MRI of the pelvis, and ultrasonography were planned with the rheumatology and gynecology consultations.
From cough to Schwannoma diagnosis: a case report
Authors: FİDANCI İzzet , AKSOY Hilal , AYHAN BAŞER Duygu
Published: September 2023

The complaints of sore throat and cough are the symptoms that we encounter frequently in our daily routine, and it is important to remember that if not thoroughly examined, different underlying diseases can be revealed. Our case was applied to the family medicine outpatient clinic with complaints of sore throat and cough, and a mass appearance was observed during the chest radiography requested due to abnormal findings from the sounds coming from the patient's lung. Thus, the mass was detected early, and we presented the patient with the diagnosis of Schwannoma, whose mass was removed.
Why should we be careful while drinking green tea?
Authors: FİDANCI İzzet
Published: September 2023

Green tea is a widely consumed beverage renowned for its numerous positive health effects. However, it is crucial to be cognizant of certain considerations, as excessive consumption can result in adverse outcomes. Green tea offers numerous health benefits; however, certain considerations should be taken into account. Therefore, it is essential for individuals to tailor their green tea consumption based on their specific health status and requirements.
Cytotoxic activity of TRPV4 antagonist RN-1734 in G-361 human melanoma cancer cell line
Authors: GÜLEŞ Özay , BİLİCİ Esra , KURBASEVIC Emira , LENGER Ömer Faruk , BOYACIOĞLU Murat , EPİKMEN Erkmen Tuğrul
Published: September 2023

Purpose: Intracellular calcium (Ca2+) signaling plays a role in many cellular events, such as cell proliferation and differentiation, gene transcription, oxidative stress, the antioxidant system, and apoptosis. Transient receptor potential vanilloid 4 (TRPV4) channels are non-selective cation (Ca2+) channels. The present study aims to investigate the cytotoxic activity of RN-1734, a transient receptor potential vanilloid 4 (TRPV4) antagonist, in the G361 human melanoma cancer cell line.

Materials and Methods: The effects of RN-1734 on G361 cell viability at concentrations of 1, 5, 25, 50, and 100 μM were measured using the 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide (MTT) method. Total antioxidant status (TAS) and total oxidant status (TOS) levels were determined using a ready-made commercial kit, after which oxidative stress index (OSI) values were calculated. To determine the apoptotic effects of RN-1734, Bcl-2, Bax, and p53 expression levels, caspase-3 and -8 activities were examined via quantitative real-time PCR analysis.

Results: G361 cell viability significantly decreased to 82.72, 72.81, 56.36, 39.16 and 18.96% in RN-1734 groups (1, 5, 25, 50 and 100 μM) compared to the control group (100.00%). At IC50 concentration (39.48 μM), RN-1734 application (3.35 mmol/g prot.-TAS, 45.87 μmol/g prot.-TOS, and 1501.97 AU-OSI) increased the TAS level (2.17 mmol/g prot.) and decreased the TOS level (55.41 μmol/g prot.) and OSI value (3142.76 AU) compared to the control group.

Conclusion: Our findings show that RN-1734 may be a novel therapeutic approach to treating melanoma by decreasing the cell viability of G361 human melanoma cancer cells.
Sinus vein thrombosis and epileptic seizures: outcomes of long term follow-up
Authors: PEKÖZ Mehmet Taylan , DEMİR Turgay
Published: September 2023

Purpose: In the acute phase of Cerebral Venous Sinus Thrombosis (CVST), approximately 35-50 % of patients diagnosed epileptic seizures. This study aimed to investigate the demographic and clinical characteristics, frequency of seizures, prognosis of patients during a one-year follow-up period.

Materials and Methods: The files of patients who were followed up with the diagnosis of acute ischemic stroke between January 1, 2018 and January 1, 2022 were evaluated in this retrospective study. Demographic features, presence of seizure history and seizure frequency, neuroimaging findings, affected cerebral venous sinuses, and anti-seizure medication use were recorded.

Results: A total of 701 patients with acute stroke had their medical records reviewed. Thirty-two of 701 patients (4.56 %) were diagnosed with CVST; 37.5 % of patients experienced early-onset seizures. Seizure control was achieved with monotherapy in 88.8 % (n:8) of patients with seizures. Involved sinuses in patients with seizures; 50 % (n=6) superior sagittal sinus was the most commonly involved sinus and inferior sagittal sinus and sinus rectus were not involved. In terms of sinus involvement, there was no statistically significant difference between patients with and without seizures. On cerebral magnetic resonance imaging, venous infarcts were detected in 66.7 % (n=8) of patients with seizures, compared to 35 % of patients without seizures.

Conclusion: This retrospective study revealed that seizures typically occur early in the disease, have a favorable prognosis over the long term, and can be managed with monotherapy.
Distribution and antifungal susceptibility of clinical Trichosporon spp. isolates: 10 years of single-center experience
Authors: GÜMÜŞ Hatice Hale
Published: September 2023

Purpose: The genus Trichosporon, which is a yeast-like basidiomycete, is ubiquitous in nature and a part of human microbiota. It’s an oppurtunistic fungal pathogen, which was once rare, but increasing dramatically recently, leading to fatal infections. The aim of this study was to determine the prevalence, and antifungal susceptibility of clinical Trichosporon spp. isolates, and to determine whether there was a change in incidence during the COVID-19 Pandemic.

Materials and Methods: This was a retrospective cross-sectional descriptive study, conducted between January 1, 2013 and February 5, 2023. Cultures which Trichosporon spp. isolated (n=125) were screened, and those met the eligibility criteria were included (n=77). Identification, antifungal susceptibility test results, age, gender records were identified from Microbiology Laboratory Information Management System.

Results: 97.4% of the isolates were Trichosporon asahii, and 2.6% were Trichosporon mucoides. The most frequent isolation period was the 2016 and 2019 year group (71.4%), not during the COVID-19 Pandemics (19.5%). The most common sample type was urine (58.4%), of whom predominantly (58.4%) hospitalized in the Intensive Care Unit. Amphotericin B MICs were ≤1µg/ml in 68.9% of the isolates. Fluconazole and voriconazole MICs were ≤1µg/ml in 20.0% and 94.8%, respectively. 59.7% of the isolates had a MIC of ≥4µg/ml for flucytosine. Micafungin and caspofungin MICs were ≥4µg/ml in 88.3% and 92.2% of the isolates, respectively. Voriconazole had the strongest in vitro activity, and amphotericin B had lower MICs than expected. The combination therapy of voriconazole and amphotericin B could be a therapeutic option in this setting, as well as monotherapy of voriconazole.

Conclusion: Trichosporon spp. isolated in clinical specimens and their antifungal susceptibility depend on the geographic region and the anatomic site. Identifying local data will contribute to both the management of these patients, and surveillance studies.
Masseter kası yeni bir parça Anatomi ve Embriyolojisi: Pars coronoidea tartışması
Authors: ÖZANDAÇ POLAT Sema , KARA Samet
Published: September 2023

Dörtgen şeklinde kalın bir kas olan masseter kasının en temel görevi mandibula’yı maxilla’ya karşı eleve etmek, dişlerin ısırma ve çiğneme işlevlerini gerçekleştirmek suretiyle çeneyi kapatmaktır. Lateral hareketlerde ve mandibula protraksiyonunda az da olsa görev alan masseter kası, esasen yüz estetiğinde oldukça önem arz eden dört çiğneme kasından biridir. Aralık 2021’de Mezey ve ark.ları tarafından yayınlanan bir makalede, anatomik olarak, masseter kasına ait derin farklı üçüncü bir tabakanın os temporale processus zygomaticus medial yüzeyinden, coronoideus posterior kenarına ve köküne doğru uzandığı gösterildi. Masseter pars coronoidea olarak adlandırılan bu yapının masseter kasına ait üçüncü ve yeni bir parça olduğu ileri sürüldü. Bu çalışma, bilim dünyasında oldukça ilgi çekici bulunduğu kadar, beraberinde bazı soru işaretlerinin varlığını da gündeme getirmiş ve tepkilere neden olmuştur.

Sunulan bu çalışmada, geçmişten günümüze masseter kasının, embriyolojik gelişimleri ile anatomik ve histolojik yapılarının güncel bilgiler ışığında gözden geçirilmesi ve yeni bir tanımlama olarak bilim dünyasına sunulan masseter kası ile ilgili tartışmanın tüm yönleriyle ele alınması amaçlandı.
Sosyal Bilgiler Ders Kitaplarında Eleştirel Düşünme Becerisinin Yeri
Authors: AVCI AKÇALI Aslı , BAŞ Özgür
Published: September 2023

Bu çalışmanın temel amacı eleştirel düşünme becerisinin ortaokul sosyal bilgiler ders kitaplarında ne düzeyde yer aldığını tespit etmektir. Bu yolla ders kitaplarının niteliğinin iyileştirilmesine yönelik çıkarımlar yapılarak öneriler sunulabilmesi hedeflenmiştir. Araştırmada nitel araştırma desenlerinden durum çalışması kullanılmıştır. Araştırma verileri araştırmacının geliştirmiş olduğu doküman inceleme formu kullanarak toplanmış, betimsel analiz yöntemine dayalı olarak analiz edilmiştir. Araştırmanın çalışma materyalini 2021-2022 eğitim öğretim yılında kullanılmakta olan ve Millî Eğitim Bakanlığı tarafından hazırlanan 5., 6. ve 7. sınıf sosyal bilgiler ders kitapları oluşturmaktadır. Kitapların üniteler içi etkinlikler ile ölçme-değerlendirme bölümleri ayrı olarak değerlendirilmiştir. Araştırma sonuçlarına göre ders kitaplarının eleştirel düşünme becerisine dair içeriği hem sınıf seviyesine göre hem de ünite içi etkinlikler ve ölçme-değerlendirme bölümleri arasında farklılık göstermektedir. Eleştirel düşünme etkinliklerinin öğrenme alanlarına göre dağılımı açısından da önemli oransal farklılıkların bulunduğu görülmüştür. Ayrıca ünite içi ve ölçme-değerlendirme bölümlerinde eleştirel düşünme alt becerilerinin desteklenme oranlarında dengesizlikler görülmüş, bazı alt becerilerle ilgili hiçbir içeriğin bulunmadığı tespit edilmiştir.
Ekonomik Büyümenin Sektörel Belirleyicilerinin İş Gücü Açısından Değerlendirilmesi: Panel Veri Analizi
Authors: DİLBER Caner
Published: September 2023

İş gücü verimliliğinin en önemli göstergelerinden biri şüphesiz üretilen mal ve hizmetlerin reel değeridir. Yüksek iş gücü verimliliğine sahip ülkeler uluslararası ticarette her zaman rekabet avantajını da ellerinde tutacaklardır. Üç temel sektör olarak değerlendirilen tarım, hizmet ve sanayi sektörlerinde çalışan iş gücünün reel hâsıla üzerindeki etkilerini araştırmak verimliliklerinin karşılaştırılması açısından önemli bir gösterge olabilir. Bu çalışmada 153 ülke için tarım, hizmet ve sanayi sektöründe çalışan işgücünün reel hasıla üzerindeki etkisi panel veri analizleri ile incelenmiştir. Yatay kesit bağımlılığı, birim kök, homojenite ve eşbütünleşme testlerinden sonra panel AMG (Augmented Mean Group) modeli kullanılarak tahminler yapılmıştır. Analiz sonuçlarına göre tarım sektöründe çalışanların toplam çalışanlar içindeki oranı %1 arttığında reel GSYH’nın parasal değeri %0,13 azalmaktadır. Diğer taraftan sanayi sektöründe çalışanların toplam çalışanlar içindeki oranı %1 arttığında ise reel GSYH’nın parasal değeri %0,34 artmaktadır. Hizmet sektörü için kurulan modelde ise istatistiki olarak anlamlı bir ilişki tespit edilememiştir.
Brand Crisis Communication and Consumer Brand Engagement on Social Media: The Case of Frontline Employee Generated Crisis
Authors: OMERAKI ÇEKİRDEKCİ Şahver
Published: September 2023

Social media enables brands to communicate instantly with consumers and drive user engagement. However, consumers’ brand engagement on social media is not always positive, especially in the presence of a crisis. Consumer brand engagement becomes more complicated given consumers’ empowerment through social media and the brands’ multiple stakeholders that shape brands’ value. The purpose of this research is to explore consumers’ multi-valenced online comments to a brand crisis communication initiated by front-line employees’ misbehavior to a group of consumers in the retail environment. Data was collected from the brand crisis communication that was shared on the official Instagram account of the brand. Focusing on real time Instagram data from consumers that reside in a collectivistic culture, a typology was developed to classify the hybrid and multi-valenced forms of consumer brand engagement. The study contributes to the consumer brand engagement and brand crisis communication literatures.
Gelişmekte olan bir ekonomide yeni girişimlerin hayatta kalması ve erken dönem başarısını etkileyen unsurların niteliksel karşılaştırmalı analiz yöntemiyle incelenmesi
Authors: TOPALER Başak
Published: September 2023

Bu çalışmanın amacı, gelişmekte olan bir ekonomide faaliyet gösteren yeni girişimlerin hayatta kalması ve erken dönem başarısını etkileyen unsurların incelenmesidir. Söz konusu olgunun teorik karmaşıklığı ve gelişmekte olan ülke ekonomilerindeki dinamiklerine ilişkin yönlendirici öncül çalışmaların eksikliği göz önüne alınarak keşifsel bir araştırma tasarlanmıştır. Hayatta kalma ve başarı üzerinde etkili olabilecek çevresel, örgütsel ve kuruculara ilişkin bir faktör seti önerilerek bunlar arasındaki ilişkiler niteliksel karşılaştırmalı analiz (QCA) yöntemi kullanılarak incelenmiştir. Çalışmanın görgül ortamı Türkiye yeni girişim (startup) ekosistemidir. Bulgular, farklı düzeylerdeki unsurlar arasındaki karmaşık etkileşimlerin yeni girişimlerin hayatta kalması ve başarısında (erken dönemde birleşme/satın alma) etkili olabileceğine işaret etmektedir. Çevresel, örgütsel ve kuruculara ilişkin özelliklerin farklı kombinasyonları bu iki sonuca ulaşmada alternatif yollar sağlayabilmektedir. Hayatta kalma yerel yetkinliklerin etkin kullanımı ile mümkün olabilse de erken dönemde birleşme/satın alma gibi bir başarı yakalayabilmek daha ziyade global yetkinliklere sahip olmakla ilişkilidir.
Manajemen Pra-Produksi Film Pendek Geger
Authors: Kariem Ahsan Jihadan Aulia , Khairiyyah Rizqi Lailatul , Zaharany Annisa Adya
Published: September 2023

Film Geger merupakan sebuah film pendek skala produksi mandiri (Proman) sebuah program kerja Cinema Komunikasi UMY. Penelitian ini membahas tentang manajemen pra-produksi film Geger. Penelitian ini berfokus kepada bagaimana produser film Geger ini bisa melakukan pra produksi secara baik disaat pandemic Covid-19. Metode penelitian yang digunakan ialah metode penelitian deskriptif kualitatif dengan sumber data berasal dari wawancara. Hasil dari penelitian tersebut ialah produser film Geger mempersiapkan segala hal secara matang dalam manajemen pra produksi berlangsung seperti membuat timeline, merekrut kru, membuat ide cerita, menentukan lokasi, sarana dan prasarana semua dipersiapkan selama pra produksi. Hal tersebut dilakukan untuk meminimalisir hal yang tidak diinginkan pada saat produksi dan pasca produksi, karena mempersiapkan pra produksi sangatlah penting dalam proses pembuatan film.
Analisis Model Komunikasi Polres Magelang Kota dalam Meningkatkan Ketertiban Lalu Lintas
Authors: Rosdiana Anggita Cahya , Lintang Muliawanti
Published: September 2023

Lalu lintas merupakan salah satu aspek penting dalam kehidupan sehari-hari, terutama di kota-kota besar yang memiliki penduduk padat. Namun, permasalahan yang sering terjadi adalah masih banyak pengguna jalan yang melanggar peraturan lalu lintas, seperti melanggar lampu merah, berbelok sembarangan, parkir ditempat yang tidak seharusnya, dan lain sebagainya. Penelitian ini bertujuan untuk mengetahui, menganalisis, dan mendeskripsikan strategi komunikasi Satlantas Polres Magelang Kota dalam meningkatkan kesadaraan masyarakat tentang pentingnya taat pada aturan lalu lintas. Penelitian ini juga diharapkan dapat menjadi referensi terkait strategi komunikasi yang efektif dalam meningkatkan ketertiban lalu lintas pada satlantas kota maupun daerah lain. Metode yang digunakan adalah deskriptif kualitatif. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Adapun subjek yang diteliti adalah Satuan Lalu Lintas Polres Kota Magelang. Peneliti berfokus untuk mengidentifikasi strategi komunikasi yang digunakan oleh Satuan Lalu Lintas Polres Kota Magelang dalam meningkatkan ketertiban lalu lintas di wilayah hukumnya dengan menggunakan teori komunikasi Harold Lasswell. Hasil penelitian ini menunjukkan bahwa dalam meningkatkan ketertiban lalu lintas satlantas polres Magelang Kota menggunakan media sosial seperti Instagram, facebook dan twitter; media outdoor seperti baliho, spanduk, dan billboard; media elektronik seperti videotron; dan melakukan sosialisasi ketertiban lalu lintas.
Analisis Peran Humas Komisi Pemilihan Umum Kabupaten Magelang Dalam Menjalankan Aktivitas Kehumasan
Authors: Putri Sekar Amalia , Lintang Muliawati
Published: September 2023

Pentingnya peranan Humas dalam sebuah organisasi/intansi sejalan dengan fungsi tugas Humas dalam menjaga citra kepada khalayak umum. Penelitian ini membahas bagaimana peran Humas KPU Kabupaten Magelang dalam Menjalankan Aktivitas Kehumasannya serta untuk mengetahui faktor pendukung dan penghambat dari aktivitas Humas KPU Kabupaten Magelang. Penelitian ini menggunakan metode kualitatif deskriptif dengan analisis data menggunakan Teori Peran dan Fungsi Humas oleh Scott dan Allen. Hasil dari penelitian ini menyimpulkan bahwa Humas KPU Kabupaten Magelang menjalankan perannya dengan baik yaitu sebagai communicator dengan menyelenggarakan program sosialisasi pemilu bagi pemula, sebagai relationship yang mana KPU Kabupaten Magelang menjalin hubungan dengan media dan stekeholder lainnya, sebagai back up management dengan upaya membagi anggota tim agar membantu bagian yang lainnya, dan sebagai good image maker dengan melakukan branding di sosial media.
Surgical versus non-surgical interventions for distal radius fractures: a quantitative analysis of patient-rated wrist evaluation measures
Authors: S. Gill Saran , Namireddy Srikar R.
Published: September 2023

Trials to assess differences in PRWE (Patient related wrist evaluation) over time, for both surgical and non-surgical interventions post DRFs (distal radius fractures) are rare. The DASH (Disabilities of the arm, shoulder and hand) questionnaire has been shown to be improved by a greater margin in the medium term for surgical interventions, than non surgical interventions. However, a study found that PRWE can be considered superior to the DASH questionnaire for DRFs, due to greater specificity to wrist pain and function. Conflicting data makes it difficult to determine surgical vs non-surgical superiority for DRF’s over time with PRWE as a recovery metric. PubMed and Cochrane were searched for randomised controlled trials up to 31.8.23, reporting PRWE over 3, and 12 months. Data was extracted by 2 researchers. The differences in PRWE over time post surgical and non-surgical interventions was assessed using unpaired T testing. 1226 records were screened. Four studies enrolling 817 participants met the eligibility criteria and were analysed. Significantly lower PRWE in surgical intervention has been identified at the 3 month mark (p<0.001). There was greater significant change in non-surgical intervention between months 3 and 12 (p<0.001). Change in PRWE over time may be a good indicator of functional outcomes in DRFs post surgical or non-surgical interventions. This could inform future clinical trial design and surgical decision-making. Further work is required to design even more user-friendly and digital patient-reported outcomes specifically for DRFs.
Addressing hypersensitivity reactions induced by Daratumumab: A review of management approaches and preventive measures
Authors: Mariya Rose , Cheriyan Basil
Published: September 2023

Daratumumab is a novel and remedial monoclonal antibody with broad-spectrum killing activity. It has shown a favorable safety profile as monotherapy in cases with relapsed/refractory multiple myeloma. Daratumumab along with its remedial benefits is associated with a range of Adverse Drug Reactions (ADRs) most importantly Hypersensitivity reactions that can significantly impact patient outcomes and health-related quality of life. The standard of care can be maintained by administering pre-infusion prophylactic medications and also by optimizing the Daratumumab infusions. The review focuses on the adverse drug reactions induced by Daratumumab, various preventative measures, and management strategies opted for curbing the Daratumumab-mediated infusion-related hypersensitivity reactions.
Comparison of CBNAAT and AFB screening using Ziehl Neelsen stain and fluorescent stain on FNAC sample for rapid diagnosis of tubercular lymphadenitis
Authors: Jayakumar Priya , Kaushal Manju , Duggal Nandini
Published: September 2023

: Tuberculous lymphadenitis is the most common etiology of cervical lymphadenopathy in endemic countries. Fine needle aspiration of palpable lymph nodes is done for rapid diagnosis of tuberculous lymphadenitis This study presents a comparative evaluation of fine needle aspiration cytology (FNAC) with acid fast bacilli screening using Ziehl Neelsen stain, Fluorescent stain with Cartridge based nucleic acid amplification test (CBNAAT) for the rapid diagnosis of tubercular lymphadenitis.

: An observational cross sectional study was done over a period of 15 months from January 2020 to March 2021. All newly diagnosed cases of tubercular lymphadenitis irrespective of age and sex were included. Fine needle aspiration was performed from the palpable lymph node. Smears were prepared using Giemsa, Papanicolaou, Ziehl Neelsen and Auramine O stain.Rest of the sample was used for Mycobacterial growth indicator test (MGIT) and CBNAAT. Statistical Analysis was performed using McNemar test. For gold standard, MGIT as well as a composite reference standard on parameters that included MGIT, radiological findings of tuberculosis, Positive Mantoux test and Positive response to ATT seen in the form of complete resolution of clinical and radiological findings.

: The diagnostic value of CBNAAT differed with respect to the chosen gold standard. With MGIT as gold standard, CBNAAT had the highest sensitivity, specificity, positive predictive value and negative predictive value. The diagnostic accuracy of CBNAAT was also the highest. Using CRS (Composite Reference standard) as gold standard, CBNAAT showed the highest specificity and positive predictive value.

: With CBNAAT showing statistically significant data of a higher diagnostic value in our study as well as showing rapid result, being automated and not subjected to observer interpretation, we conclude that CBNAAT is more efficient in the diagnosis of tubercular lymphadenitis as compared to AFB screening methods. The only limitation of CBNAAT in our study was its ability to show positive results for three atypical mycobacteria due to possible cross contamination.
Morphological perspective of skin adnexal tumours: A case series
Authors: Hota Sarbashis , Ghosh Sukanya , Jha Sneha , Das Tushar Kanti
Published: September 2023

Adnexal or appendageal tumours of skin comprise an important subcategory of cutaneous neoplasms, although thorough understanding of this entity is still in its early stages. The role of immunohistochemistry in diagnosis is particularly limited, and, it is morphology that actually guides pathologists for clinching diagnosis. Here, we present three uncommon cases of skin adnexal tumours- a case of retiform trichoblastoma, trichilemmal carcinoma and sebaceous carcinoma; especially highlighting the morphological approach of diagnosis and the associated clinical implications based on literature review.
Malignant phyllodes tumor with heterologous sarcomatous element: A rare case report
Authors: Asotra Sarita , Sharma Shikha , Asotra Sehar , Chandel U K
Published: September 2023

Phyllodes tumors being a rare neoplasm of the breast attributes only 0.3% to 1% of all breast tumors, with an annual incidence of about 2 per million women. Malignant differentiation of phyllodes tumors can occur, resulting in cases of extremely rare heterologous sarcomatous differentiation.

We present a rare case of a 63-year-old women with features of malignant phyllodes with sarcomatous (chondrosarcomatous) differentiation.

Morphologically, phyllodes tumors are categorized as benign, borderline and malignant based on the scope of stromal atypia, mitotic activity, stromal overgrowth, and the tumor margins. The presence of heterologous elements in a phyllodes directly upgrades it to a malignant category. A close follow-up with a CT scan is of utmost need to detect the recurrence and metastasis to the earliest.
Xanthoma- A case report
Authors: Gokhale Tanvi , Jindal Richa , Joseph Molly , Kaur Kuldeep , Nawale Ankita
Published: September 2023

Xanthomas are lesions that are mostly located within the skin or subcutaneous tissue and consist of cholesterol and cholesterol esters. Xanthomas can occur at any site. They are mostly associated with Familial hypercholesterolemia. Although the clinical picture is variable, a high level of LDL cholesterol is the common manifestation. Here we report a case report on multiple Xanthomas in a 19 years old male.
A rare case report of familial multiple lipomatosis and its diagnostic approach with review of literatures
Authors: Verma Kartavya Kumar
Published: September 2023

Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also, syndromic associations were documented. Familial multiple lipomatosis (FML) is an autosomal dominant disorder. It presents as multiple lipomas in the body at specific sites. In presenting case 26-year-old patient complained of multiple swellings in his forearms, both thigh, and anterior abdominal wall for 5 years. A diagnosis of multiple lipomatosis is made by Fine needle aspiration cytology and confirmed by histopathological examination.
In memoriam ks. prof. Antoniego Siemianowskiego (28.05.1930 – 4.12.2022)
Authors: Pietryga Piotr
Published: September 2023

Tekst jest poświęcony pamięci Księdza Antoniego Siemianowskiego (1930-2022) — profesora filozofii, absolwenta Katolickiego Uniwersytetu Lubelskiego. Artykuł jest najszerszym dotąd opracowaniem życiorysu Księdza Profesora Siemianowskiego wraz z prześledzeniem jego poglądów filozoficznych — zbiera dotychczasowe publikacje dotyczące Księdza Profesora i dokonuje ich syntezy. Autor miał zamiar wskazać na najważniejsze momenty z życia duchownego-filozofa, który zapisał się w pamięci przestrzeni akademickich Kujaw i Wielkopolski — najbardziej w Inowrocławiu, z którego pochodził, a także Gniezna, z którym był związany poprzez pracę wykładowcy, przez ponad pół wieku. Tekst analizuje drogę intelektualną Księdza Profesora od edukacji szkolnej, poprzez studia filozoficzno-teologiczne, studia doktoranckie, a w końcu poszukiwanie „własnej drogi w filozofii” — drogi od historii filozofii, poprzez tomizm do fenomenologii. Zwrócić należy uwagę, że Ksiądz Siemianowski nie zajmował się jedynie pracą naukową, ale był także jako prezbiter katolicki duszpasterzem, który także poprzez nauczanie pokoleń przyszłych kapłanów formował w nich styl myślenia, zgodnie z zasadą, że „filozofia jest służebnicą teologii”. Inną przestrzenią aktywności Księdza Siemianowskiego była publicystyka — nawiązawszy współpracę z wieloma czasopismami, popularyzował na ich łamach wiedzę z zakresu etyki, filozofii kultury czy antropologii filozoficznej.
II wojna światowa w diarystyce Iwana Bunina
Authors: Bielniak Nel
Published: September 2023

Iwan Bunin niemal całe życie prowadził dzienniki, które pełniły różne funkcje, charakteryzowały się ponadto fragmentarycznością i nieciągłością. W diariuszu pisarz odnotowywał m.in. istotne dla niego wydarzenia i towarzyszące im emocje. Znalazły się w nich również jego przemyślenia dotyczące II wojny światowej, którą pisarz spędził głównie na południu Francji. Bunin uważnie śledził i komentował przebieg działań wojennych na świecie i losy kolejnych zaangażowanych w nią krajów. Konflikt na terytorium dawnej ojczyzny skłonił diarystę m.in. do złagodzenia wypowiedzi o ZSRR, jak też do wspomnień o kraju ojczystym. Z kolei opis francuskich realiów wojennych obfituje w szczegółowe uwagi o warunkach bytowych i zdrowotnych Bunina i jego bliskich, przedstawia ponadto skomplikowaną i niepewną sytuację rosyjskich emigrantów. A wszystkie zapiski okraszone są rozważaniami o przemijaniu, czasie, śmierci czy pamięci.
The Tender Narrator In Guzel Yakhina’s Zuleikha
Authors: Głąb Anna
Published: September 2023

The main assertion in this paper is that the tender narrator, whom the Polish writer, Olga Tokarczuk, made the subject of her Nobel Lecture, can convey the author’s perspective in such a way that all readers can find themselves in it. Using the example of Guzel Yakhina’s Zuleikha, the author of this paper demonstrates how tender narration brings out the titular character’s defenselessness as a quality of the human condition. The author ponders what distinguishes Yakhina’s novel among other examples of camp or historical literature and also addresses Hélène Cixous’s concept of l’écriture feminine, concluding that the perspective of tender narration is coextensive with the feminine narration that is open to voices arriving from a multitude of perspectives. The author also demonstrates that Yakhina’s Zuleikha is an example of literature that highlights and explores the experience of a human being’s internal freedom, which is inalienable, even though its external freedom may be endangered by fate, the laws of history or political machinations.
Białorusin? Rosjanin? Homo soveticus? Problem tożsamości narodowej w dramatach Maksima Dośki
Authors: Gulina Anastasia
Published: September 2023

Od początku XXI wieku na Białorusi w warunkach prawie całkowitego braku niezależnych mediów teatr, a w większym stopniu – dramat współczesny, pełnił funkcje publicystyczne, poruszając tak ważne tematy, jak postawa obywatelska, konflikty międzypokoleniowe, przemoc domowa oraz problem tożsamości narodowej. W artykule są analizowane utwory dramatopisarza białoruskiego Maksima Dośki (Radio Kultura, Londyn) pod kątem charakterystyki jego bohaterów z punktu widzenia tożsamości narodowej. Celem jest pokazanie jak owa kategoria funkcjonuje i rozwija się w warunkach dwujęzyczności, jak wpływają na nią postkolonialne zjawiska mentalne. Bohaterowie sztuk Maksima Dośki to zwykli mieszkańcy białoruskiej prowincji lub przedmieść Mińska, nieświadomie szukający odpowiedzi na najważniejsze pytania, związane z mentalnością i tożsamością. Jednocześnie charakteryzują się oni brakiem tradycji kulturowej, a nawet nieznajomością języka ojczystego. Wykorzystując podejście interdyscyplinarne, autor artykułu analizuje tożsamość bohaterów dramatu białoruskiego, zastanawiając się, czy czują się oni przedstawicielami niepodległego państwa, czy nadal funkcjonują w modelu homo soveticus, przedstawionym w książce publicystycznej Swietłany Aleksijewicz Czasy secondhand. Koniec czerwonego człowieka .
Protective Effect of L-Carnitine against Deltamethrin Induced Male Reproductive Toxicity in Adult Rats Exposed at their Prepubertal Stage
Authors: Thathapudi Daveedu , Yendluri Raja Jayarao , Adimulapu Anilkumar , Gunda Mahesh , Vadela Manohar , Sainath S. B. , Manohar P. R. V.
Published: September 2023

The present study aims to investigate the protective role of L-Carnitine (LC) against Deltamethrin-induced testicular toxicity in male rats exposed during their early developmental period. DTM was administered at a dose of 6 mg/kg body weight to the prepubertal rat’s Post-Natal Day (PND) 23 rats through oral route and exposure was continued until they reach PND 90. After completion of the exposure period, male rats were assessed for reproductive endpoints. Deltamethrin exposure caused a significant reduction in testosterone production and decreased the sperm parameters such as sperm count, sperm motility, sperm viability and sperm membrane integrity. Deltamethrin intoxication also reduced the reproductive organs’ weight and testicular steroidogenic enzymes (3β-hydroxysteriod dehydrogenase and 17β-hydroxysteriod dehydrogenase) levels. Further DTM exposure induced the oxidative stress as evidenced by the significant reduction in the superoxide dismutase, catalase, and glutathione levels with significant elevation in the malondialdehyde. DTM also induced the significant sperm DNA damage. In addition, DTM exposure significantly declined the testosterone levels over the control group, indicating the impaired steroidogenesis. In addition to the compromised steroidogenesis DTM exposure also deteriorated the testicular architecture according to the histological observations. On the other hand, therapy with LC (100 mg/kg body weight) improved the biomass of reproductive organs, the features of the sperm, testicular steroidogenesis and testicular antioxidant enzymes levels. Concluding that DTM might disturb the testicular antioxidant level that eventually impaired the reproductive health of rats. However, LC supplementation mitigated the reproductive toxicity through its antioxidant property.
In vivo Acute Toxicity and Anti-inflammatory Activity of Ferula sulcata Desf. from Setif, Algeria
Authors: Rahmouni Malika , Hamoudi Meriem , Mlik Randa , Laouer Hocine , Khennouf Seddik , Dahamna Saliha , Mekhadmi Nour Elhouda , Mouane Aicha
Published: September 2023

Several works are interested in studying the undesirable therapeutic effects of medicinal plants, which must be used with great caution because they can be toxic. Under this objective falls our work, which consists in studying the acute toxicity and anti-inflammatory action in vivo of the Essential Oil (EO) of the aerial part (seed) of Ferula sulcata Desf. harvested from the region of Setif in western Algeria. Two doses were applied by oral gavage (2000 and 5000 mg/kg body weight). After administration of the oil, the mice were continuously monitored for 14 days. The results obtained showed that there was no mortality or morbidity whereas the animals showed toxic effects e.g., behavioral and morphological changes. On the other hand, a significant increase (p<0.05) in body weight was observed. In addition, an important increase was recorded in the relative organ weights compared to the controls, whereas the liver was significantly increased (**p<0.05): 6.12±0.19; 6.14±0.31 in females compared to controls. Furthermore, ALT value decreased significantly (**p<0.05): 6.83±2.59 in males. In addition, the oral administration of EO at the dose of 600 mg/kg showed an interesting antiinflammatory activity comparable to indomethacin. Histopathological damage was observed in the liver and kidney tissues of mice treated with EO of this plant. Hence, the acute toxicity and anti-inflammatory activities of EO of F. sulcata Desf. are considered the first data.
Toxicological Evaluation of Vaisvanara churna an Ayurvedic Formulation
Authors: Ilavarasan R. , Arunadevi R. , Thomas Susan , Jamadagani Shrirang Balkrishna , Gaidhani Sudesh N. , Thenmozhi M. , Manikandan N.
Published: September 2023

Vaisvanara churna an ayurvedic formulation was screened for its toxicity profile. The study was carried out based on CCRAS Protocols. For the acute oral toxicity study, Group I served as vehicle control, Vaisvanara churna at a single oral dose of 6500 mg/kg b.w., was administered to 5 male and 5 female Swiss albino mice (Group II) and observed for 14 consecutive days for clinical signs, body weight and mortality. For 90 days repeated dose toxicity study eighty animals (40 male and 40 female) were distributed into four groups. Group I served as vehicle control. Groups II, III, and IV were administered with 450, 2250 and 4500 mg/kg b.w., respectively for 90 days orally. During this period, feed intake, body weight, signs of toxicity, haematological and biochemical parameters were recorded at periodical intervals. After 90 days animals were sacrificed for necropsy, vital organs were weighed and preserved for histopathological analysis. In an acute toxicity study, a single dose of Vaisvanara churna at 6500 mg/kg b.w., caused no mortality in animals, suggesting that the median lethal dose is greater than 6500 mg/kg b.w. In 90-day, repeated dose toxicity study, administration of Vaisvanara churna for 90 days, up to 4500 mg/kg b.w., caused no significant changes in body weights or organ weights of rats in the treated groups when compared with the control group. In addition, haematological and biochemical parameters were within the physiological limits. Histopathological analysis revealed no signs of degeneration. These results showed that Vaisvanara churna is apparently safe as indicated therapeutically for long-term administration for chronic ailments.
Karakteristik Fisikokimia, Mikrobiologi, dan Uji Pasar Yogurt Smoothies Rosela Stroberi pada Usia Remaja dan Dewasa di Bogor
Authors: Berutu Putra Jahtra , Arief Irma Isnafia , Soenarno Mochammad Sriduresta , Dekriyatna Lucya Cyrilla Eko Nugrohowati Supriyadi
Published: September 2023

Yogurt is a dairy product that is processed into a fermented drink using lactic acid bacteria. Smoothies are drinks made from fruit or vegetables containing milk, yogurt, or honey. Strawberry Rosella Yogurt Smoothie is yogurt that has been processed by reducing the water content and adding rosella flower extract and strawberry jam. Before being marketed, these products need to be tested for safety and market opportunities. This study aims to analyze the physicochemical characteristics, microbiology, and market tests of strawberry rosella yogurt smoothies in adolescents and adults in Bogor. The physicochemical characteristics tested included pH, water activity (aw), viscosity, and total titrated acid. The microbiological parameters tested were total lactic acid bacteria and Salmonella sp. The market parameters tested include analysis of consumer perceptions and preferences and their correlation with yogurt consumption patterns. The market test was carried out using 100 respondents consisting of 50 students from SMAN 1 Bogor and 50 students from IPB University. The results showed that the physical properties (pH, water activity, viscosity, and total lactic acid) fulfilled the SNI yogurt quality requirements. The chemical properties or nutritional content and microbiological properties of yoghurt smoothies have met the requirements for yoghurt quality standards based on SNI. The results showed that respondents had good perceptions and preferences on the attributes of smoothie yogurt. Consumer preferences regarding the appearance of the packaging in general, color, ingredient content, packaging information, and appearance of the contents of the yogurt are generally positively correlated with the price range of yogurt that consumers buy. Strawberry Rosella Yoghurt Smoothie is safe for consumption and can be marketed.   Keywords: consumer perception, consumer preferences, microbiology, physicochemistry, yogurt smoothies
Keamanan Mikrobiologis Air Minum Isi Ulang dan Perubahannya Selama Penyimpanan
Authors: Tasya Fitri Yunada  , Winiati Pudji Rahayu  , Dian Herawati
Published: September 2023

Indonesians use refilled drinking water which can be obtained at depots because of practical and affordable reasons. Low levels of sanitation and hygiene and storage of refilled drinking water for an extended period can lead to the possibility of the growth of indicator and pathogenic microorganisms such as Coliform and Escherichia coli (E. coli). This study aims to evaluate the application of drinking water refilling stations (DWRS) sanitary hygiene, microbiological quality and safety of refilled drinking water and its changes during storage. Samples of refilled drinking water were taken from two DWRSs for each region in five areas of DKI Jakarta including West, East, South, North, and Central Jakarta. The treatments in this study were refilled drinking water storage in gallons of closed and open-closed conditions at room temperature (28 + 2°C) for 0, 7, and 14 days. The results of observations showed that 30% (n=30) of depots complied with hygiene sanitation standards according to Permenkes RI No. 43 of 2014 (>70%). The analysis results showed that refilled drinking water at 0 days of storage, 100% met the TPC (5 Log CFU/mL), 20% met the total Coliform standard (0 Log CFU/mL), and 80% met the E. coli standard (0 Log CFU/mL) according to Permenkes RI No. 492 of 2010. Storage times of 0, 7, and 14 days of refilled drinking water had a significant effect on TPC and total Coliform (P < 0.05), but had no significant effect on E. coli (P > 0.05) in gallons with closed and open-closed conditions.

 

Keywords: Coliform, DWRS, E. coli, refilled drinking water
Sifat Fisika dan Mekanika Kayu Acacia aulacocarpa dari KHDTK Wanagama
Authors: Gaol Nur Indah Lumban , Hidayati Fanny , Nugroho Widyanto Dwi , Praptoyo Harry , Karyanto Oka , Marsoem Sri Nugroho
Published: September 2023

This study aims to determinethe physical properties and mechanical properties at axial (base, middle, and top) and radial (near the pith, middle, and near the bark) positions, as well as the relationship between the specific gravity and mechanical properties of Acacia aulacocarpa wood. Three 27-year-old trees planted at KHDTK Wanagama wereused. Wood physical and mechanical propertieswere tested per British Standard 373:1957. The statistical analysis used was a two-way ANOVA and a follow-up test of Tukey HSD. The results showed that the average moisture content was 98.95%; the green and air-dry sepesific gravity were 0.58 and 0.61. Radial, tangential, and longitudinal shrinkage from green to oven-dry conditions (total shrinkage) were 2.02%, 5.09%, and 0.33%. The tangential/radial (T/R) ratio was 2.80%. The static bending strength of stress at proportion limit, MoE, and MoR were 498.13 kg/cm2, 116.16x1000 kg/cm2, and 1043.68 kg/cm2, respectively. The compressive strength parallel to the grain and perpendicular to the grain were 596.05 kg/cm2 and 227.25 kg/cm2, respectively. The results of the variance analysis showed that the radial position factor has a significant effect on green moisture content, green and air-dry specificgravity, total radial shrinkage, T/R ratio, static bending strength at stress of proportion limit, MoE, MoR, compressive strength parallel to the grain, and compressive strength perpendicular to the grain. However, the axial position factor did not show any significant differences in the physical and mechanical properties of the wood. Furthermore, air-dry specific gravity has a significant moderate to high positive correlation with all mechanical properties.

Keywords: Acacia aulacocarpa, physical properties, mechanical properties, axial position, radial position