bluuebunny/crossref_metadata_2025 huggingface dataset:
Very High-energy Afterglow Emission of GRB 190829A: Evidence for Its Hadronic Origin?
Authors: Sahu Sarira , Valadez Polanco Isabel Abigail , Rajpoot Subhash
Published: April 2022

The detection of multi-TeV gamma rays from the afterglow phase of GRB 190829A by the High Energy Stereoscopic System telescope is an addition to the already existing list of two GRBs observed in very high-energy (VHE) gamma rays in recent years. Jets of blazars and GRBs have many similarities and the photohadronic model is very successful in explaining the VHE gamma-ray spectra from the high-energy blazars. Recently, the photohadronic model has been successfully applied to study the sub-TeV gamma rays from the afterglow phases of GRB 180720B and GRB 190114C. We employed this model again to explain the VHE spectra observed for the two consecutive nights from GRB 190829A. We show that the spectra of GRB 190829A can be due to the interactions of high-energy protons with the synchrotron self-Compton photons in the forward shock region of the GRB jet, similar to the low emission state of the VHE flaring events of high-energy blazars. We speculate that, if in the future, it is possible to observe the VHE gamma-ray spectra from nearby GRBs in their afterglow phases, then some of them could only be explained by employing two different spectral indices. If confirmed, such VHE spectra could be interpreted as a result of the interactions of the high-energy protons with the photons, both from the synchrotron background and the synchrotron self-Compton background in the forward shock region.
A Single-pulse Study of the Subpulse Drifter PSR J1631+1252 Discovered at FAST
Authors: Wen Z. G. , Yuan J. P. , Wang N. , Li D. , Chen J. L. , Wang P. , Wu Q. D. , Yan W. M. , Yuen R. , Wang Z. , Tedila H. M. , Wang H. G. , Zhu W. W. , Niu J. R. , Miao C. C. , Xue M. Y. , Duan X. F. , Xiang B. B. , He D. L.
Published: April 2022

We report on the pulse-to-pulse energy distribution and longitude-resolved modulation properties of PSR J1631+1252 discovered by the Five-hundred-meter Aperture Spherical radio Telescope. Our analysis made use of the data acquired at 1250 MHz from the follow-up timing observations that lasted over a year. PSR J1631+1252 has a rotational period of ∼0.310 s, and a dispersion measure of ∼32.73 pc cm−3. The energy distribution is well described by a lognormal distribution, the parameters of which do not vary with time. We show that large modulation occurs across the bridge emission of the pulse profile, with sporadic bright bursts at the leading emission region. The fluctuation spectral analysis reveals the existence of subpulse drifting in the leading component with vertical spacing between the drift bands of 3.28 ± 0.08 pulse periods between consecutive drift bands. Possible physical mechanisms for subpulse drifting are discussed.
The Interstellar Medium in the Environment of the Supernova-less Long-duration GRB 111005A
Authors: Leśniewska Aleksandra , Michałowski M. J. , Kamphuis P. , Dziadura K. , Baes M. , Cerón J. M. Castro , Gentile G. , Hjorth J. , Hunt L. K. , Jespersen C. K. , Koprowski M. P. , Floc’h E. Le , Miraghaei H. , Guelbenzu A. Nicuesa , Oszkiewicz D. , Palazzi E. , Polińska M. , Rasmussen J. , Schady P. , Watson D.
Published: April 2022

Long (>2 s) gamma-ray bursts (GRBs) are associated with explosions of massive stars, although in three instances, supernovae (SNe) have not been detected, despite deep observations. With new H i line and archival optical integral-field spectroscopy data, we characterize the interstellar medium (ISM) of the host galaxy of one of these events, GRB 111005A, in order to shed light on the unclear nature of these peculiar objects. We found that the atomic gas, radio continuum, and rotational patterns are in general very smooth throughout the galaxy, which does not indicate a recent gas inflow or outflow. There is also no gas concentration around the GRB position. The ISM in this galaxy differs from that in hosts of other GRBs and SNe, which may suggest that the progenitor of GRB 111005A was not an explosion of a very massive star (e.g., a compact object merger). However, there are subtle irregularities of the GRB 111005A host (most at a 2σ level), which may point to a weak gas inflow or interaction. Because in the SE part of the host there is 15% more atomic gas and half the molecular gas than in the NW part, the molecular gas fraction is low. In the SE part there is also a region with a very high Hα equivalent width. There is more continuum 1.4 GHz emission to the SE and an S-shaped warp in the UV. Finally, there is also a low-metallicity region 3.″5 (1 kpc) from the GRB position. Two galaxies within 300 kpc or a past merger can be responsible for these irregularities.
The Refined Transit Ephemeris of TOI-2180 b
Authors: Dalba Paul A. , Jacobs Thomas Lee , Omohundro Mark , Gagliano Robert , Jursich Jay , Kristiansen Martti H. , LaCourse Daryll M. , Schwengeler Hans M. , Terentev Ivan A.
Published: April 2022

The Transiting Exoplanet Survey Satellite (TESS) observed a single transit of the giant exoplanet TOI-2180 b in Sector 19 of its primary mission. A subsequent effort to characterize this system found that the orbital period of TOI-2180 b is 260.8 ± 0.6 days. This level of precision precludes most efforts to detect future transits and to further understand this exoplanet. We present a new transit of TOI-2180 b observed by TESS in Sector 48 and update the planet’s transit ephemeris with its precisely measured orbital period. The refined ephemeris enables future transit observations to explore this planet’s atmosphere or to search for rings or moons.
Factors Related to Depression among Caregivers Attending Post-Ischemic Stroke Patients
Authors: Khaddafi Muhammad Rio , Loebis Bahagia , Nasution Nazli Mahdinasari , Rambe Aldy Safruddin , Effendy Elmeida , Amin Mustafa M.
Published: April 2022

BACKGROUND: Stroke is known as chronic disease, leading to disability which makes help from caregivers become necessary. Attending stroke patients possess certain challenges and burdens toward the caregivers.

AIM: We aim to investigate risk factors related to depression among caregivers attending post-ischemic stroke.

METHODS: Eighty-three caregivers and post-ischemic stroke patients were collected consecutively from the Neurology Department of Universitas Sumatera Utara Hospital, Medan, Indonesia. Linear regression was used to analyze the data.

RESULTS: Our multivariate study shows that patient’s age, caregiver’s gender, patient’s gender, and modified Barthel Index are associated with depression with adjusted R2 of 59.3%.

CONCLUSION: Early detection and intervention should be addressed regularly for caregivers attending post-stroke patients.
Four new Parasterope (Ostracoda, Myodocopina) from the Northwest Pacific and their phylogeny based on 16S rRNA
Authors: Pham Huyen T. M. , Karanovic Ivana
Published: April 2022

Parasterope Kornicker, 1975 is a marine ostracod genus with 49 species described so far, which makes it the most diverse representative of the subfamily Cylindroleberidinae, as well as the entire family Cylindroleberididae. Despite its global distribution no species are reported from South Korea. Three new species collected from the Korean coast of the Sea of Japan (Parasterope busanensissp. nov., P. singulasp. nov., and P. sohisp. nov.), and one from the Japanese coast of the Pacific Ocean (P. sagamisp. nov.) are described. A taxonomic key to all named species from East Asia is provided. A phylogenetic tree is reconstructed based on partial 16S rRNA sequences of the four new species and other Cylindroleberidinae available from GenBank. Monophyly of Parasterope is supported by high posterior probabilities, but the phylogenetic analyses also indicate that some of the GenBank data attributed to this genus are probably misidentifications. A map of distribution and a checklist of all described Parasterope species are also provided.
Ergothérapie en psychiatrie
Authors: Guihard Jean-Philippe
Published: April 2022

Résumé La folie ou les folies interroge(nt) nos pratiques cliniques quant à leur validité. Mais elle(s) interroge(nt) aussi les concepts qui sous-tendent ces pratiques. Ainsi, pourquoi l’ergothérapie a-t-elle sa place dans le processus thérapeutique relatif au(x) folie(s) et en quoi l’activité, l’acte et l’action sont-ils des données fondamentales dans cette perspective ? La place donnée à la parole est prépondérante alors que le lieu et le lien de rencontre du sujet sont l’activité véritablement porteuse de signification et partageable socialement. Cette thérapie des troubles de l’activité humaine ne serait-elle pas l’ergon-thérapie ?
Ergothérapie en psychiatrie
Authors: Koch Béatrice
Published: April 2022

Résumé Le monde de la psychiatrie évolue, tant dans la diversité d’offres de thérapies que dans les nouvelles directives de santé publique. Se sensibiliser à une démarche évaluative en santé mentale devient incontournable. Cette approche répond à la fois à des critères d’efficience, à nos valeurs professionnelles mais prend surtout une place dans l’alliance thérapeutique. Elle permet de mieux connaître et de mieux accompagner nos patients dans leur projet personnalisé et de s’intégrer pleinement dans leur parcours de soin. À travers une petite étude, 24 patients ont bénéficié pendant 6 mois d’un suivi ergothérapique avec une visée évaluative. L’outil ELADEB et 6 autres, qui découlent du Modèle de l’occupation humaine de G. Kielhofner, vont être présentés et comparés, pour saisir l’impact de leur usage dans le fonctionnement de vie, voire, un maillon dans le processus de changement de ces personnes.
Ergothérapie en psychiatrie
Authors: Gumy Marc
Published: April 2022

Résumé Dans un cadre institutionnel, cette communication évoque une partie de l’histoire thérapeutique d’une jeune fille souffrant de graves troubles narcissiques. Son traitement nous a mené à la rencontre des éléments corporels de la composition du narcissisme et des contenants de pensée archaïques. Les moyens mis en œuvre sont exposés chronologiquement : un groupe thérapeutique ; une médiation corporelle : le massage ; un atelier : la sculpture. Ils illustrent une certaine manière d’intégrer un mode de compréhension psychodynamique, le champ cognitif et l’approche corporelle.
Crowdfunding et transition énergétique : analyse empirique des plateformes de financement participatif des projets d’énergies renouvelables en France
Authors: Lesgards Valérie , Stelitano Salvatore
Published: April 2022

Cet article vise à mieux comprendre la réalité du crowdfunding en France, en termes de contribution à la transition énergétique et en termes d’engagement citoyen dans les projets d’énergies renouvelables. La méthodologie utilisée est une analyse statistique exploratoire quantitative des données en open source recueillies sur 9 plateformes de crowdfunding . Les résultats montrent qu’à l’horizon 2030, les projets de crowdfunding pourraient contribuer à hauteur de 33 % à l’objectif national de 216 TWh de production d’énergies renouvelables fixé par la loi. Cette estimation repose sur la poursuite du modèle actuel dans lequel le citoyen investit en moyenne 2 643 € par projet et finance 14 % en moyenne du coût total du projet. Ces résultats sont comparés avec ceux de la littérature et quelques recommandations sont également formulées pour renforcer le crowdfunding au service de la transition énergétique. Codes JEL : O30, G23
L’agenda législatif sur la gouvernance d’entreprise soutenable : le point de vue des entreprises de l’Afep
Authors: De Brosses Odile
Published: April 2022

La législation française impose de plus en plus d’aborder les sujets de responsabilité sociale et environnementale des entreprises (RSE) en termes de gouvernance d’entreprise. Les grandes entreprises françaises adhérentes de l’Afep partagent la conviction qu’il importe de veiller à l’adéquation de leur organisation avec l’objectif de développement durable. Elles ont adopté unilatéralement des engagements et des procédures pour ce faire. En outre, le Code de gouvernement d’entreprise des sociétés cotées adopté par l’Afep-Medef intègre diverses recommandations sur la nécessaire intégration des enjeux environnementaux et sociaux dans le système de gouvernance. Pour autant, les grandes entreprises françaises sont aussi préoccupées de voir la France multiplier les initiatives unilatérales déconnectées des réalités européennes et internationales. L’adoption d’un cadre européen harmonisé et compatible avec les référentiels normatifs internationaux a leur préférence. L’enjeu écologique repose à nouveau des questions classiques de la gouvernance d’entreprise. En allongeant la liste des intérêts à prendre en considération dans la gestion de la société, la crise écologique renforce l’importance des dirigeants pour arbitrer les conflits dans le sens de l’intérêt propre de la société.
L’agenda législatif du Parlement européen sur la gouvernance d’entreprise soutenable : le point de vue de Marie Toussaint, eurodéputée (EELV)
Authors: Toussaint Marie
Published: April 2022

À l’heure actuelle, la gouvernance d’entreprise n’est toujours pas adaptée aux enjeux environnementaux, climatiques et sociaux du XXI e  siècle. Pourtant, il y a urgence à repenser et réformer les règles applicables aux entreprises pour qu’elles intègrent véritablement les répercussions de leurs activités sur le climat, la biodiversité ou encore les droits humains, et qu’elles répondent de leurs actes. Si les choses commencent doucement à évoluer au niveau européen, nous devons être vigilants et rester ambitieux afin de passer d’un droit souple à un droit réellement contraignant qui assurerait en particulier le respect des objectifs climatiques fixés dans l’Accord de Paris. Une réflexion sur le temps long, la prise en compte des limites planétaires dans les stratégies internes élaborées par les entreprises ou encore la pénalisation des comportements préjudiciables pour l’environnement font partie intégrante de ces solutions ambitieuses mais nécessaires pour reconnecter l’humain avec le vivant.
L’entreprise dans la pensée juridique américaine : brèves perspectives historiques
Authors: Abadie Pauline
Published: April 2022

L’approche historique de la notion d’entreprise, à travers ses diverses constructions doctrinales et les applications jurisprudentielles auxquelles elle a donné lieu, éclaire sur la manière dont les juristes outre-Atlantique appréhendent un sujet aussi essentiel dans l’avènement du capitalisme moderne. La généalogie des débats qui ont animé la doctrine enseigne que l’entreprise, loin de l’étiquette qui lui est trop souvent affublée, n’a pas toujours été la chose d’actionnaires cupides ou le jouet de managers perchés dans leur tour d’ivoire, et que la question de ses responsabilités sociales a été beaucoup plus vite perçue aux États-Unis qu’en France. L’intérêt de l’analyse historique consiste à mettre en exergue la permanence des problématiques soulevées et à tracer l’horizon pour projeter des évolutions déjà bien tangibles.
Galien Restoré vs Galen Rethoré : pour une lecture comparée
Authors: Colombo Timelli Maria
Published: April 2022

La version en prose de Galien est transmise par un manuscrit du xv e  siècle et un incunable d’Antoine Vérard (1500) ; malgré d’indéniables similarités, les deux textes demeurent assez différents pour que les éditeurs modernes (Keller–Kaltenbach, 1998) aient choisi de les éditer séparément, l’un à la suite de l’autre. Ayant pour but de vérifier l’hypothèse d’une source commune, cet article suit un parcours en trois étapes : après avoir comparé la structure des deux versions (organisation interne des chapitres / paragraphes), on propose la collation de quelques passages représentatifs (naissance de Galien, miracle du soleil arrêté, exécution de Ganelon) en ayant recours, lorsque cela est possible, à la source en vers, le Galien dit « de Cheltenham » ; une dernière collation est menée sur les expressions proverbiales communes au manuscrit et à l’imprimé.
« Elle fondit en larmes afin de l’inciter à la fureur. » Humiliation, genre et émotions autour de la révolte poitevine de 1241–1242
Authors: de Vasselot de Régné Clément
Published: April 2022

En 1241, un bourgeois de La Rochelle, pour prévenir Blanche de Castille des préparatifs des barons poitevins en vue d’une révolte, lui envoie une lettre très détaillée dont les précisions ont souvent été prises au premier degré et utilisées pour tirer un portrait psychologique à charge des acteurs de la rébellion, en particulier d’Isabelle d’Angoulême. En réalité, la comtesse-reine mobilise ou transgresse à dessein un langage émotionnel et des codes comportementaux partagés par l’ensemble des acteurs de la révolte. Cette missive est d’une extrême richesse pour appréhender ces codes qui régissent la théâtralisation des émotions au xiii e  siècle et leur dimension genrée. Joint aux autres textes relatifs à la révolte de 1241–1242, ce document exceptionnel illustre ainsi combien le jeu de l’humiliation et le langage émotionnel font le lien entre les représentations mentales et leur traduction en actes, occupent une place majeure dans la communication politique ou les relations entre puissants et contribuent à la bonne marche des stratégies de gouvernement.
La présomption Bosphorus après l’arrêt Bivolaru et Moldovan de la Cour européenne des droits de l’homme : un bouclier de papier ?
Authors: Platon Sébastien
Published: April 2022

L’arrêt Bivolaru et Moldovan de la Cour européenne des droits de l’homme, en date du 25 mars 2021, est le premier arrêt dans lequel la Cour a constaté une insuffisance manifeste de protection des droits fondamentaux permettant de renverser la présomption de respect de la Convention européenne des droits de l’homme dont bénéficient, sous certaines conditions, les États membres de l’Union européenne lorsqu’ils exécutent le droit de l’Union. Au-delà de cette solution, le raisonnement de la Cour laisse apparaître les faiblesses structurelles de cette présomption.
Pluralisme des statuts de conjugalité imposé aux plus récalcitrants des Européens
Authors: Lamarche Marie
Published: April 2022

La défense d’une conception traditionnelle du mariage – formé d’un couple de personnes de sexe différent ayant pour but la procréation et l’éducation des enfants – ne saurait impliquer la négation des droits des personnes homosexuelles. La Cour européenne des droits de l’homme rappelle, dans l’arrêt Fedotova et autres c. Russie , l’obligation d’assurer le respect de la vie privée des couples de personnes de même sexe en leur fournissant un statut juridique.
Psychological Behavior, Work Stress, and Social Support of Frontline Nurses During the COVID-19 Pandemic
Authors: Li Xixi , Wang Haiyan , Wu Yuanchen , Ma Yanfei
Published: April 2022

Using a cluster sampling method, 248 nurses from frontline departments of three large general hospitals in Sichuan Province, China, were selected as participants in the current study. Risk perception and coping methods during the coronavirus disease 2019 (COVID-19) pandemic, negative emotions and psychological workload, and awareness of social support among nurses were studied. Negative emotions among nurses increased significantly, with fear being the most common (73.4%,
n
= 182). Psychological workload of nurses in close contact with patients with COVID-19 was higher than that of nurses in other positions (
p
< 0.05). Family was the major source of social support. Social support was negatively associated with depression (−0.206,
p
< 0.05), obsessive-compulsiveness/anxiety (−0.185,
p
< 0.05), and hypochondriasis (−0.234,
p
< 0.05). Psychological workload of nurses was positively correlated with depression (0.251,
p
< 0.05), neurasthenia (0.242,
p
< 0.05), and obsessive-compulsiveness/anxiety (0.231,
p
< 0.05). Nursing staff in frontline departments encountered psychological workload burdens to varying degrees during the COVID-19 pandemic. Thus, it is important to implement and strengthen psychological counseling for nurses in close contact positions, and to seek family and social support for nurses. [
Journal of Psychosocial Nursing and Mental Health Services, 60
(10), 21–27.]
Pediatric Anxiety and Depression in the Time of COVID-19
Authors: Beharry Meera
Published: April 2022

Pediatricians and other primary care clinicians are responsible for the screening of numerous health issues. As the coronavirus disease 2019 (COVID-19) pandemic persists, the adverse mental health effects on patients, their families, and the community at large are evident. Therefore, pediatricians are tasked with assessing, triaging, and initiating treatment for common mental health concerns such as anxiety and depression. Complicating the picture is long-COVID. This article reviews the epidemiology of pediatric and adolescent anxiety and depression and data about pediatric long-COVID. Additionally, strategies and tools for pediatricians and their office staff to address the mental health needs of their patients are outlined.

[
Pediatr Ann
. 2022;51(4):e154–e160.]
The Effect of COVID-19 on the Mental Health of Military Connected Children and Adolescents
Authors: Lawson Michelle L. , Bowsher Barbara , Hansen Shana
Published: April 2022

With a growing body of literature describing the coronavirus disease 2019 (COVID-19) pandemic's effect on children and adolescents, there remain few official reports regarding mental health in military connected youth. With sparse literature available specifically in youth associated with the Armed Forces, published studies on global child and adolescent mental health during the COVID-19 pandemic are first reviewed. Military connected youth have unique needs and experiences. Implications of pandemic-related stressors on their mental health are suggested based on analysis of disaster and deployment literature. Military members have continued to move and deploy throughout the pandemic. Uniformed families have high risk factors for mental health concerns. Managing the mental health of military connected youth will fall heavily on civilian providers, both in primary and subspecialty practices. As such, vigilance for psychological health concerns and familiarity with military resources are vital for the mental wellness of our military pediatric patients.

[
Pediatr Ann
. 2022;51(4):e138–e143.]
Objective Physical Activity Levels, Sedentary Time, and Muscle Mass, Strength, and Function: Impact on Physical and Mental Health-Related Quality of Life in Older Adults
Authors: Taani Murad H. , Strath Scott J. , Cho Chi C. , Ellis Julie , Oh Hyunkyoung
Published: April 2022

Limited physical activity, sedentary behavior, and reduction in muscle mass, strength, and function are accompanied by negative outcomes. The relationship between these factors and physical and mental health-related quality of life (HRQoL) has yet to be elucidated in continuing care retirement community (CCRC) residents. The current study investigated the relationships among physical activity, sedentary behavior, and muscle mass, strength, and function to physical and mental HRQoL. A sample of 105 CCRC residents participated in this cross-sectional correlational study. Findings demonstrated that low physical activity and muscle function were significantly associated with low physical HRQoL and explained 38% of the variance in physical HRQoL. Handgrip strength was significantly associated with low mental HRQoL and explained 8% of the variance in mental HRQoL. Older adults living in CCRCs may benefit from interventions targeting physical activity and the distinct muscle components of sarcopenia that have the potential to improve physical and mental HRQoL. [
Research in Gerontological Nursing, 15
(3), 131–139.]
Repair of Rhegmatogenous Retinal Detachment in Choroideremia Secondary to Posterior Extramacular Retinal Hole
Authors: Wang Jay C. , Qian Cynthia X. , Comander Jason I.
Published: April 2022

Rhegmatogenous retinal detachment in choroideremia is a rare occurrence. The authors present a case of a 23-year-old man with choroideremia with a near-total rhegmatogenous retinal detachment. Fundus examination did not reveal any retinal breaks, but extensive preoperative optical coherence tomography detected a small posterior hole along the superior arcades. The retinal detachment was successfully managed with vitrectomy, perfluorooctane to confirm the absence of any peripheral breaks, endolaser, and 20% sulfur hexafluoride gas. Similar extramacular holes were found in the patient's other eye. Patients with choroideremia may develop posterior retinal breaks leading to retinal detachment.
Course of Diabetic Retinopathy in Untreated Fellow Eyes in RIDE and RISE: A Post Hoc Analysis
Authors: Bakri Sophie J. , Malhotra Mila , Stoilov Ivaylo
Published: April 2022

BACKGROUND AND OBJECTIVE:

To characterize diabetic retinopathy (DR) progression without therapy.

PATIENTS AND METHODS:

This post hoc analysis of the phase 3 RIDE and RISE trials examined the association between baseline DR severity on rates of ≥ 2-step DR progression and improvement in untreated fellow eyes (n = 530) and ranibizumab-treated study eyes (n = 369). Kaplan–Meier analyses estimated progression to proliferative DR (PDR) over 2 years in eyes with nonproliferative DR (NPDR) at baseline.

RESULTS:

At month 24, 28.8% of untreated fellow eyes with moderately severe to severe NPDR at baseline experienced ≥ 2-step DR progression, versus 10.3% of eyes with absent to moderate NPDR and 0 eyes with mild- to high-risk proliferative DR. Of the untreated fellow eyes with moderately severe to severe NPDR, 18.9% achieved ≥ 2-step DR improvement, compared with 88.4% of ranibizumab-treated eyes.

CONCLUSION:

Without treatment, patients with moderately severe to severe NPDR are at risk of rapid disease progression and vision loss.

[
Ophthalmic Surg Lasers Imaging Retina
. 2022;53(4):202–207.]
Improved collision detection of MD5 with additional sufficient conditions
Authors: Fang Linan , Wu Ting , Qi Yongxing , Shen Yanzhao , Zhang Peng , Lin Mingmin , Dong Xinfeng
Published: April 2022

One application of counter-cryptanalysis is detecting whether a message block is involved in a collision attack, such as the detection of MD5 and SHA-1. Stevens and Shumow speeded up the detection of SHA-1 by introducing unavoidable conditions in message blocks. They left a challenge: how to determine unavoidable conditions for MD5. Later, Shen et al. found that the unavoidable conditions of MD5 were the sufficient conditions located in the last round of differential paths. In this paper, we made further work. We discover sufficient conditions in the second round that can also be used as unavoidable conditions. With additional sufficient conditions, we subdivide three sets and distinguish seven more classes. As a result, compared with Shen's collision detection algorithm, our improved algorithm reduces the collision detection cost by 8.18%. Finally, we find that they do exist in the differential paths constructed by the automatic tool "HashClash".
A numerical study of fractional population growth and nuclear decay model
Authors: Alzaid Sara S. , Shaw Pawan Kumar , Kumar Sunil
Published: April 2022

This paper is devoted to solving the initial value problem (IVP) of the fractional differential equation (FDE) in Caputo sense for arbitrary order $ \beta\in(0, 1] $. Based on a few examples and application models, the main motivation is to show that FDE may model more effectively than the ordinary differential equation (ODE). Here, two cubic convergence numerical schemes are developed: the fractional third-order Runge-Kutta (RK3) scheme and fractional strong stability preserving third-order Runge-Kutta (SSRK3) scheme. The approximated solution is derived without taking any assumption of perturbations and linearization. The schemes are presented, and the convergence of the schemes is established. Also, a comparative study has been done of our proposed scheme with fractional Euler method (EM) and fractional improved Euler method (IEM), which has linear and quadratic convergence rates, respectively. Illustrative examples and application examples with the numerical comparison between the proposed scheme, the exact solution, EM, and IEM are given to reveal our scheme's accuracy and efficiency.
Properties for fourth order discontinuous differential operators with eigenparameter dependent boundary conditions
Authors: Li Kun , Wang Peng
Published: April 2022

In this paper, a class of fourth order differential operators with eigenparameter-dependent boundary conditions and transmission conditions is considered. A new operator associated with the problem is established, and the self-adjointness of this operator in an appropriate Hilbert space $ H $ is proved. The fundamental solutions are constructed. Sufficient and necessary conditions of the eigenvalues are investigated. Then asymptotic formulas for the fundamental solutions and the characteristic functions are given. Finally, the completeness of eigenfunctions in $ H $ is given and the Green function is also involved.
« Caius Lucretius […], marchand de couleurs de la rue des fabricants de courroies ». Réflexions critiques sur les concentrations de métiers à Rome
Authors: Monteix Nicolas
Published: April 2022

En dépit d’une absence chronique de définition, l’idée de regroupement topographique est très forte dans les études récentes sur les espaces de production du monde romain. Initialement développée à partir de l’exemple de l’Vrbs, et reposant sur des indices topographiques majoritairement transmis par l’épigraphie funéraire, cette théorie s’est progressivement étendue au reste de l’Empire jusqu’à donner naissance à la notion de « quartier artisanal », qui suppose que certaines portions de l’espace urbain étaient vouées à la seule fonction productive. Après un détour par les concepts de la géographie urbaine, une analyse critique des mentions de localisation dans les inscriptions d’hommes de métier à Rome est développée. Avec un corpus de 138 inscriptions, certaines redondances de formulation permettent de proposer une hypothèse sur les raisons qui ont amené ces praticiens à indiquer leur lieu d’exercice dans leur épitaphe. Si une idée de « quartier » doit être maintenue, elle ne saurait se distinguer de l’espace vécu, incluant l’ensemble du paysage urbain. Pour le domaine des activités économiques, seule la notion de concentration paraît opératoire, bien qu’elle ne constitue qu’un constat initial et non une interprétation en soi.
A Single-Domain TCR-like Antibody Selective for the Qa-1b/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint
Authors: Ghaffari Soroush , Upchurch-Ange Katherine , Gimlin Susanne , Tripathi Trivendra , Sluijter Marjolein , Middelburg Jim , van Hall Thorbald , Weidanz Jon
Published: April 2022

The NKG2A/HLA-E axis is an immune checkpoint that suppresses immune effector activity in the tumor microenvironment. In mice, the ligand for the NKG2A/CD94 inhibitory receptor is the nonclassical MHC molecule Qa-1b, the HLA-E ortholog, which presents the peptide AMAPRTLLL, referred to as Qdm (for Qa-1 determinant modifier). This dominant peptide is derived from the leader sequences of murine classical MHC class I encoded by the H-2D and -L loci. To broaden our understanding of Qa-1b/Qdm peptide complex biology and its tumor protective role, we identified a TCR-like Ab from a single domain VHH library using yeast surface display. The TCR-like Ab (EXX-1) binds only to the Qa-1b/Qdm peptide complex and not to Qa-1b alone or Qa-1b loaded with control peptides. Conversely, currently available Abs to Qa-1b bind independent of peptide loaded. Flow cytometric results revealed that EXX-1 selectively bound to Qa-1b/Qdm-positive B16F10, RMA, and TC-1 mouse tumor cells but only after pretreatment with IFN-γ; no binding was observed following genetic knockdown of Qa-1b or Qdm peptide. Furthermore, EXX-1 Ab blockade promoted NK cell–mediated tumor cell lysis in vitro. Our findings show that EXX-1 has exquisite binding specificity for the Qa-1b/Qdm peptide complex, making it a valuable research tool for further investigation of the Qa-1b/Qdm peptide complex expression and regulation in healthy and diseased cells and for evaluation as an immune checkpoint blocking Ab in syngeneic mouse tumor models.
Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis
Authors: Tan Chuyi , Reilly Bridgette , Jha Alok , Murao Atsushi , Lee Yongchan , Brenner Max , Aziz Monowar , Wang Ping
Published: April 2022

Extracellular cold-inducible RNA binding protein (eCIRP) is an inflammatory mediator that causes inflammation and tissue injury in sepsis. Gasdermin D (GSDMD) is a protein that, when cleaved, forms pores in the cell membrane, releasing intracellular contents into the extracellular milieu to exacerbate inflammation. We hypothesize that eCIRP is released actively from viable macrophages via GSDMD pores. We found that LPS induced eCIRP secretion from macrophages into the extracellular space. LPS significantly increased the expression of caspase-11 and cleavage of the GSDMD, as evidenced by increased N-terminal GSDMD expression in RAW 264.7 cells and mouse primary peritoneal macrophages. GSDMD inhibitor disulfiram decreased eCIRP release in vitro. Treatment with glycine to prevent pyroptosis-induced cell lysis did not significantly decrease eCIRP release from LPS-treated macrophages, indicating that eCIRP was actively released and was independent of pyroptosis. Downregulation of GSDMD gene expression by siRNA transfection suppressed eCIRP release in vitro after LPS stimulation. Moreover, GSDMD−/− peritoneal macrophages and mice had decreased levels of eCIRP in the culture supernatants and in blood treated with LPS in vitro and in vivo, respectively. GSDMD inhibitor disulfiram inhibited serum levels of eCIRP in endotoxemia and cecal ligation and puncture–induced sepsis. We conclude that eCIRP release from living macrophages is mediated through GSDMD pores, suggesting that targeting GSDMD could be a novel and potential therapeutic approach to inhibit eCIRP-mediated inflammation in sepsis.
Zebrafish CERKL Enhances Host TBK1 Stability and Simultaneously Degrades Viral Protein via Ubiquitination Modulation
Authors: Chen Dan-Dan , Lu Long-Feng , Xiong Feng , Wang Xue-Li , Jiang Jing-Yu , Zhang Can , Li Zhuo-Cong , Han Ke-Jia , Li Shun
Published: April 2022

In the viral infection process, host gene function is usually reported as either defending the host or assaulting the virus. In this study, we demonstrated that zebrafish ceramide kinase-like (CERKL) mediates protection against viral infection via two distinct mechanisms: stabilization of TANK-binding kinase 1 (TBK1) through impairing K48-linked ubiquitination and degradation of spring viremia of carp virus (SVCV) P protein by dampening K63-linked ubiquitination, resulting in an improvement of the host immune response and a decline in viral activity in epithelioma papulosum cyprini (EPC) cells. On SVCV infection, ifnφ1 expression was increased or blunted by CERKL overexpression or knockdown, respectively. Subsequently, we found that CERKL localized in the cytoplasm, where it interacted with TBK1 and enhanced its stability by impeding the K48-linked polyubiquitination; meanwhile, the antiviral capacity of TBK1 was significantly potentiated by CERKL. In contrast, CERKL also interacted with and degraded SVCV P protein to disrupt its function in viral proliferation. Further mechanism analysis revealed K63-linked deubiquitination is the primary means of CERKL-mediated SVCV P protein degradation. Taken together, our study reveals a novel mechanism of fish defense against viral infection: the single gene cerkl is both a shield for the host and a spear against the virus, which strengthens resistance.
Pneumonia Severity and Phase Linked to Virus-Specific T Cell Responses with Distinct Immune Checkpoints during pH1N1 Infection
Authors: Li Hui , Zhao Min , Zhang Hangjie , Quan Chuansong , Zhang Dannie , Liu Yingmei , Liu Meng , Xue Chunxue , Tan Shuguang , Guo Yaxin , Zhao Yingze , Wu Guizhen , Gao George F , Cao Bin , Liu William J
Published: April 2022

The detailed features and the longitudinal variation of influenza-specific T cell responses within naturally infected patients and the relationship with disease severity remain uncertain. In this study, we characterized the longitudinal influenza-specific CD4+ and CD8+ T cell responses, T cell activation, and migration-related cytokine/chemokine secretion in pH1N1-infected patients with or without viral pneumonia with human PBMCs. Both the influenza-specific CD4+ and CD8+ T cells presented higher responses in patients with severe infection than in mild ones, but with distinct longitudinal variations, phenotypes of memory markers, and immune checkpoints. At 7 ± 3 d after onset of illness, effector CD8+ T cells (CD45RA+CCR7−) with high expression of inhibitory immune receptor CD200R dominated the specific T cell responses. However, at 21 ± 3 d after onset of illness, effector memory CD4+ T cells (CD45RA−CCR7−) with high expression of PD1, CTLA4, and LAG3 were higher among the patients with severe disease. The specific T cell magnitude, T cell activation, and migration-related cytokines/chemokines possessed a strong connection with disease severity. Our findings illuminate the distinct characteristics of immune system activation during dynamic disease phases and its correlation with lung injury of pH1N1 patients.
A Permian mixohaline ostracod association of the Teresina Formation, Paraná Basin, Brazil
Authors: Bergue Cristianini Trescastro , Maranhão Maria da Saudade Araújo Santos , Ng Christiano , Naumcheva Maria A.
Published: April 2022

New ostracod species are described for Middle to Upper Permian (Guadalupian) rocks of the Teresina Formation, Paraná Basin, from two localities in the São Paulo State, southwestern Brazil: Xavante Dam and Pau Preto Quarry. Paranacythere nigripallus gen. nov. and sp. nov., Velatomorpha xavante sp. nov., and Velatomorpha pseudoaltilis sp. nov. are herein described. The association Velatomorpha–Paranacythere is proposed as typical of Permian mixohaline environments of the Teresina Formation, and is the most abundant in the two studied localities. Paranacythere nigripallus gen. nov. and sp. nov. is proposed to accommodate a very abundant species with typically cytheroidean characteristics, and tentatively ascribed to the family Cytheruridae. Some ecological remarks are presented based on ostracod population age structure, biostratinomy and taxonomic composition of assemblages. The diagnosis of Velatomorpha Tibert & Dewey is emended. Keywords: evolution, marginal marine environments, paleoecology, Teresina Formation, taxonomy.
Mecanismos de fertilização inferidos através do registro de cocolitoforídeos durante o Quaternário Tardio na Margem Continental Sul-Brasileira
Authors: Gonçalves Juliana de Freitas , Leonhardt Adriana
Published: April 2022

Mechanisms of fertilization inferred from the coccolithophorid record during the Late Quaternary in the southern Brazilian Continental Margin. This study aimed to understand which fertilization mechanisms are preponderant over oceanic primary productivity and its relationship with remarkable climatic events of the Late Quaternary in the south of the Brazilian Continental Margin. The investigation was carried out through geochemical and coccolithophorid analyzes in the SIS188 marine core, recovered from the Pelotas Basin slope at 1,514 m water depth. The record shows that productivity was related to insolation (with a predominance of the precession cycle) and atmospheric processes that influence ocean dynamics. During the glacial period (MIS 3 and 2), the highest productivity intervals were associated with the expansion of the upwelling system in the Santa Marta Cape region, driven by the northeast winds. However, the interval of greatest productivity recorded in the core is the initial Holocene, when the upwelling was attenuated. This substantial increase in productivity is attributed to lagging processes resulting from the decrease in sea level that occurred during the Last Glacial Maximum. Keywords: productivity, Pelotas Basin, upwelling, Quaternary, coccolithophorids.
Post-meeting report of the 2022 On-site Padua Days on Muscle and Mobility Medicine, March 30 - April 3, 2022, Padua, Italy
Authors: Carraro Ugo , Bittmann Frank , Ivanova Elena , Jónsson Jr Halldór , Kern Helmut , Leeuwenburgh Christiaan , Mayr Winfried , Scalabrin Mattia , Schaefer Laura , Smeriglio Piera , Zampieri Sandra
Published: April 2022

Despite COVID-19 outbreak, the program of the 2022 Padua Days of Muscle and Mobility Medicine (PDM3) was confirmed On-site in February from March 30 to April 2, 2022 to be held at the University of Padua Aula Magna and at Conference Hall of the Hotel Petrarca of Thermae of Euganean Hills (Padua), Italy. Over 130 abstracts, including the last-minute submissions listed below, convinced organizers to extend the program to five days. The sponsorship of the University of Florida and the willingness of attendees to meet friends after two years of virtual conferences were the keys of success, despite concerns for current events in East Europe. Only fourteen Virtual presentations were in the final program, eight due to last-minute Coronavirus infections and six for East Europe problems. The first two days of the programincluded scientists and clinicians of the University of Florida, USA and their invitees from Canada, France, Italy, Swiden, Swiss, UK and USA. Researchers and clinicians from Austria, Belgium, France, Germany, Iceland, Ireland, Italy, Russia, Slovakia, Slovenia, UK and USA filled the program of last three days more oriented to aging and rehabilitation. The large majority of abstracts was e-published before the meeting; here are last-minute abstracts and the final program. The program of the 2023 On-site PDM3 was informally designed during the Meeting, but will be circulated during 2022 summer. Fix the dates in your agenda from Thursday March 28 to Friday March 31. For now, please, submit Communications to the European Journal of Translational Myology, PAGEpress, Pavia, Italy and Original Articles or Reviews to the Journal Diagnostics, MDPI, Basel, Swiss. Both journals will host Special PDM3 Sections and will apply 50% discount on editorial processing fees to the first 15 accepted typescripts.
Dermatoscopic Features of Onychomycosis and its Correlation with Nail Plate Potassium Hydroxide Mount (KOH), Culture, and Periodic Acid Schiff Stain (PAS) in North East India
Authors: Marak Anita , Verma Shikha , Lyngdoh Wihiwot Valerie , Dey Biswajit
Published: April 2022

Context:

Dermatoscopy has been used recently for identifying the specific features of onychomycosis. Very few studies have used it as a diagnostic tool. Our study highlights the specific patterns in different clinical types of onychomycosis and the novel features that have never been reported previously.

Aims:

To study the dermatoscopic patterns in patients with onychomycosis and determine the sensitivity, specificity, positive, and negative predictive values of the different features.

Study Design:

A cross-sectional study.

Materials and Method:

Dermatoscopic picture using dinolite video dermatoscope was taken in patients diagnosed with onychomycosis either with a positive KOH, culture, and/or PAS.

Result:

A total of 80 patients were included. Onychomycosis was identified in 68 individuals. Clinically, 73.52% presented with distal lateral subungual onychomycosis (DLSO) and 26.47% had total dystrophic (TD). PAS was positive in 85.29% of patients, KOH in 75%, and culture in 66.17%. Trichophyton species were isolated in 53.33%, whereas Candida species in 40% of patients. Dermatoscopic features were seen in all 68 patients (100%). The most common finding in decreasing order includes spike pattern, ruin appearance, distal irregular terminations (DIT), longitudinal striations, chromonychia, focal homogeneous opacities, microsplitting, and uniform homogeneous pattern. Three novel patterns were observed: homogeneous opacity with a-z pattern border, microsplitting in a Christmas tree pattern, and focal homogeneous opacities.

Conclusion:

To our knowledge, this is the first study conducted in northeast India where dermatoscopy was used as a diagnostic tool and it was found to have the highest sensitivity. New features that have not been described before have been identified.
The Unsung Signs of Dermatology
Authors: Ramesh Heera , Somashekar Sachin
Published: April 2022

“The eye sees only what the mind is prepared to comprehend.”

The term “sign” refers to an objective physical finding observed by the examiner. In dermatology, the diagnosis mainly depends on the examiner and certain physical signs serve as an important clue to diagnosis of the disease. The objective of this review is to bring to light certain lesser-known signs in dermatology.
Serum Cortisol Levels in Lichen Planus
Authors: Sushanthi L Casilda , Ramani Pratibha , Ramasubramanian Abilasha , Gheena S , Krishnan Reshma P
Published: April 2022

Lichen planus (LP) is an autoimmune, mucocutaneous, T-cell mediated chronic inflammatory disease that involves the oral mucosa. The prevalence of LP is 0.04–2% in general population with a female predilection. Patients with skin lesions also manifest oral lesions predominantly and about 25% present with only oral lesions. The aim of the systematic review is to analyze the serum cortisol levels in LP patients to elucidate the role of cortisol in pathogenesis of the lesion. A comprehensive search was done using electronic data bases such as PUBMED, EMBASE, SCIENCE DIRECT, COCHRANE, GOOGLE, manual search, and back references of the articles were extracted. A total of seven relevant articles were reviewed and analyzed. Electronic database and manual search identified 55 articles. Out of which, 33 were excluded after reading titles and removing duplication and 23 studies were evaluated in detail after reading the abstract and full text. A final of seven studies were included based on the inclusion criteria to meet the research question. All the studies analyzed the serum cortisol levels in LP patients and also in healthy subjects. Within the limitations of this review, it can be inferred that Cortisol is an established stress hormone and Serum cortisol estimation could be an important indicator in identifying susceptible oral lichen planus patients.
Etiology of corneal blindness in patients attending a tertiary care center in Kashmir
Authors: Kounser Afshan , Rasool Aalia , Wani Junaid S. , Manzoor Nadia
Published: April 2022

PURPOSE:

To study the etiology of corneal blindness in patients attending the cornea clinic of a tertiary care center of Kashmir.

MATERIALS AND METHODS:

This was a hospital-based cross-sectional study with prospective as well as retrospective recruitment of cases conducted over a period of 2 years. Patients with corneal blindness were included, and history regarding age, gender, laterality, residence, and occupation was taken.

RESULTS:

A total of 318 patients were studied with 151 (47.5%) males and 167 (52.5%) females; majority (48.8%) belonged to the age group of 31 to 50 years. 92.8% had unilateral and 7.2% had bilateral involvement, 57.2% belonged to rural and 42.8% to urban areas, and 61% were outdoor and 39% were indoor workers. The most common cause was infectious keratitis (57.54%) which included viral (25.8%), bacterial (23.27%), and fungal (8.5%). Bullous keratopathy accounted for 17.30% (aphakic 3.10% and pseudophakic 14.2%), followed by trauma 10.26% with mechanical trauma 6.29% and chemical trauma 3.46%. Advanced keratoconus accounted for 7.5% of cases and failed graft for 4.72%. Corneal dystrophies and degenerations accounted for 1.9% of cases.

CONCLUSION:

Majority of the causes of corneal blindness are preventable if addressed appropriately and timely with good health-care facilities at community level, education, awareness, and proper facilities, especially provision of protective tools and equipment at workplaces.