bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide CRISPR screen reveals genetic modifiers of Ca2+-mediated cell death
Authors: Reyes Gaido Oscar E. , Schole Kate L. , Anderson Mark E. , Luczak Elizabeth D.
Published: January 2023

Ca2+is a fundamental determinant of survival in living cells. Excessive intracellular Ca2+causes cellular toxicity and death but the genetic pathways contributing to Ca2+induced cell death are incompletely understood. Here, we performed genome-wide CRISPR knock-out screening in human cells challenged with the Ca2+ionophore ionomycin and identified genes and pathways essential for cell death after Ca2+overload. We discovered 115 protective gene knockouts, 82 of which are non-essential genes and 21 of which belong to the druggable genome. Notably, members of store operated Ca2+entry (SOCE), very long-chain fatty acid synthesis, and SWItch/Sucrose Non-Fermentable (SWI/SNF) pathways provided marked protection against Ca2+toxicity. These results reveal pathways previously unknown to mediate Ca2+-induced cell death and provide a resource for the development of pharmacotherapies against the sequelae of Ca2+overload in disease.
Mapping the field of sustainable procurement: a bibliometric analysis
Authors: Kabra Gaurav , Srivastava Samir K. , Ghosh Vinit
Published: January 2023

Purpose

The study aims to analyze the intellectual structure in sustainable procurement (SP) research to identify the knowledge research clusters and provide potential avenues for future research.

Design/methodology/approach

The study conducted a bibliometric analysis to analyze the intellectual structure in the area of SP. Overall, 1,294 articles were selected from the Scopus database published between 2000 and 2022. The analysis was conducted using bibliometric R package, Biblioshiny and VOSviewer software. Further, content analysis of research clusters was carried out to set the future research agenda.

Findings

The study identifies four major knowledge research clusters of SP, namely, (1) green supply chain practices, (2) socially responsible purchasing, (3) environmental purchasing and (4) public procurement and policy. The study suggests a few research directions in the SP field. Moreover, the future research directions are aligned with specific organizational theories applicable in the area of SP research.

Research limitations/implications

The study is dependent on the Scopus database for the source of research publications on SP. Future studies may consider other research database sources.

Practical implications

Identifying knowledge research clusters of SP research is of paramount importance for developing policies in the near future. These policy initiatives pave the way for the adoption of SP practices in the business. The findings indicate the issues managers encounter while implementing SP in organizations.

Originality/value

The study offers valuable insights concerning parameters such as significant publication outlets, influential countries concerning the number of publications, impactful authors, title keywords and identifying major knowledge research clusters of SP to suggest future research directions. Further, the present study highlights emerging areas that require further research, including process governance, supplier diversity, innovation, the role of emerging technologies and the application of organizational theories in SP.
Modeling transformational leadership, supply chain collaboration and firm performance – a case of India
Authors: Prabhu Mahesh H. , Srivastava Amit Kumar
Published: January 2023

Purpose

The competitive rivalry, rapid change and high business volatility necessitate inter-organizational collaboration, including the supply chain (SC). This paper develops an interpretive model of the effect of the chief executive officers’ (CEO's) transformational leadership (TL) style on SC collaboration and, consequently, on the firm's performance.

Design/methodology/approach

Total interpretive structural modeling (TISM) is adopted to develop a hierarchical model to delineate the association between the elements of TL, SC collaboration and firm performance. Furthermore, the model has been validated statistically.

Findings

The TISM analysis results suggest that the TL style elements require maximum attention and are strategic. These elements drive factors of SC collaboration leading to improved firm performance. Therefore, CEO leadership is critical for SC collaboration to effectively affect firm performance.

Research limitations/implications

The TISM framework in this paper preferred the majority approach over the fuzzy one, which requires a much larger data set. However, the bias of the majority approach can be eliminated by having multiple consultations with participants. Further, the development and validation of the paper was limited to manufacturing small and medium enterprises (SMEs) in India. The model can also be tested in large organizations to garner additional insights.

Originality/value

This study uniquely integrates TL and SC collaboration elements to explain firm performance. The TISM framework explains not only the “what” and “how” but also the “why” of theory building. This study also adds methodological value by combining triangulation with the interpretive tool.
Information confusion as a driver of consumer switching intention on social commerce platforms: a multi-method quantitative approach
Authors: Wang Jianming , Vo-Thanh Tan , Liu Yi-Hung , Dang-Van Thac , Nguyen Ninh
Published: January 2023

Purpose

On the basis of the approach-avoidance motivation theory, this study aims to examine the role of information confusion in influencing consumer switching intention among social commerce platforms, with the mediating effect of emotional exhaustion and the moderating role of social overload.

Design/methodology/approach

This study applied a multi-method quantitative approach including a survey and two experiments. Data were obtained from consumers on popular social commerce platforms in China. The survey's sample size was 327 respondents, whereas a total of 1,621 consumers participated in the two experiments.

Findings

Findings from the survey reveal that information confusion affects switching intention directly and indirectly via emotional exhaustion. Moreover, social overload moderates the emotional exhaustion–switching intention relationship and the indirect impact of information confusion on switching intention. Results of the two experiments further confirm the relationships found in the survey.

Originality/value

This study develops and validates a mediation and moderation model which expectedly serves as a framework to better explain consumer switching intention on social commerce platforms. The study also offers fresh insights into consumer switching intention in the unique context of social commerce in an emerging market (i.e. China), which has been largely ignored in the prior literature.
Past, present and future impact of social media on health workers’ mental health: a text mining approach
Authors: Novera Chowdhury Noushin , Connolly Regina , Wanke Peter , Rahman Md. Azizur , Azad Md. Abul Kalam
Published: January 2023

Purpose

The COVID-19 epidemic has brought attention to the variables that influence the mental health of health workers who are entrusted with nursing individuals. Despite the fact that many articles have examined the effects of social media usage on mental health, there is a lack of research synthesizing learning from this body of research. The purpose of this study is to use text mining and citation-based bibliometric analysis to conduct a detailed review of extant literature on health workers’ mental health and social networking habits.

Design/methodology/approach

This study conducts a full-text analysis of 36 articles selected on health workers' mental health and social media using text-mining techniques in R programming and a bibliometric citation analysis of 183 papers from the Scopus database in VOS viewer software. But the limitations of the methods used in this study are that the bibliometric analysis was limited to the Scopus database because the VOS viewer program did not support any other database and the text-mining approach caused the natural processing redundancy.

Findings

The bibliometric analysis reveals the thematic networks that exist in the literature of health workers’ mental health and social networking. The findings from text mining identified ten topic models, which helped to find the related papers classified in ten different groups and are provided alongside a summary of the published research and a list of the primary authors with posterior probability through Latent Dirichlet Allocation.

Originality/value

To the best of the authors’ knowledge, this is the first hybrid review, combining text mining and bibliometric review, on health workers’ mental health where social networking plays a moderating role. This paper critically provides an overview of the impact of social networking on health workers' mental health, presents the most important and frequent topics, introduces the scientific visualization of articles published in the Scopus database and suggests further research avenues. These findings are important for academics, health practitioners and medical specialists interested in learning how to better support the mental health of health workers using social media.
The “gender affinity effect” behind female politicians' social media support: facebook civil talk during Israel's 2021 elections
Authors: Samuel-Azran Tal , Yarchi Moran
Published: January 2023

Purpose

The study aims to examine the validity of the gender affinity effect on social media throughout election campaigns.

Design/methodology/approach

This paper examines the role of gender in political discourse, using citizens' conversations on Facebook in the days leading up to Israel's 2021 elections as its case study. The analysis measured the engagement generated by male and female politicians in citizens' publicly open Facebook discussions (N = 1875) using a trend-tracking software. The analysis uses t-tests to examine differences in engagement between conversations about male versus female politicians and between posts written by male versus female authors. In addition, a two-way ANOVA analysis was conducted in an attempt to understand the shared impact of both the politicians' gender and posts authors' gender on the posts' engagement.

Findings

The study reveals that although more posts discuss male politicians, posts dealing with female politicians expressed significantly more support towards those politicians. The analysis also highlights that women tend to write more supportive posts and that most of their posts deal with female politicians. Furthermore, interaction effect analysis revealed that women's posts about female politicians generate more engagement in terms of likes, comments and number of participants than posts written by women that deal with male politicians.

Practical implications

The findings should encourage women politicians to run their campaigns via social media.

Originality/value

The study presents the first social media analysis for gender affinity effect and highlights the importance of the effect in online political communication studies.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-04-2022-0199
From Great Resignation to Great Re-Negotiation on space and time for more holistic individuals and organizations
Authors: Liu Leigh Anne
Published: January 2023

Purpose

This paper aims to offer a new perspective to conceptualize the Great Resignation from the cognition of space and time, as well as the opportunity to re-negotiate space and time arrangements in personal and organizational lives. As a result, the paper provides new ideas for developing more holistic and sustainable individuals and organizations to survive and thrive in challenges of global disruptions.

Design/methodology/approach

Drawing from anthropology and psychology works in space and time, this paper proposes new ideas for individuals and organizations to negotiate space and time arrangements that facilitate holistic personal growth and sustainable organizational lives.

Findings

This research raises a critical point on the need to reconceptualize and renegotiate work arrangements about where we work and when we work. Anthropologist Edward Hall suggests that work should be viewed from multiple lenses that connotate different meanings of space and time in different parts of the world. Instead of separating professional and personal lives, we need to cultivate a more holistic mindset and renegotiate space and time settings at work.

Originality/value

This research broadened current conceptualizations of the Great Resignation and organizational behavior around work arrangements. From an interdisciplinary perspective, this paper suggests that individuals and organizations negotiate space and time arrangements for more agile and resilient future.
Tinkering with (in)visibilities: Caring for older people with surveillance technologies
Authors: Kamp Annette , Grosen Sidsel Lond , Hansen Agnete Meldgaard
Published: January 2023

New surveillance technologies have in later years been introduced in care for older people as part of a broader policy agenda of ‘sustainable’ welfare state retrenchment, promoting ideals of self‐sufficiency and empowerment of older people ‘ageing in place’. Drawing on newer approaches to surveillance studies, this article explores care workers’ active labour in creating (in)visibility in a complex and ongoing process of tinkering, while negotiating political rationales of empowerment and professional accountability. Hence, visibilities are conceived as coded, reflecting different ideals and rationales. Based on extensive fieldwork in Danish eldercare, we analyse two forms of surveillance: virtual homecare and sensor‐flooring, where clients are involved and positioned in different ways in accomplishing surveillance. We illuminate how the process of accomplishing (in)visibility does not only involve tinkering with technology, but also with spatial arrangements in the client’s home, and with clients’ behaviour. Consequently, we underscore how tinkering may turn out to be a difficult and even conflictual task of negotiating professional authority and accountability in ways that resonate with clients’ sense of autonomy and policy ideals of empowerment. Our studies underline how the power dynamics of surveillance in care should not be overlooked, even though they are continuously negotiated in care practices.
Genome‐wide re‐sequencing data reveals the genetic diversity and population structure of Wenchang chicken in China
Authors: Tian Shuaishuai , Li Wei , Zhong Ziqi , Wang Feifan , Xiao Qian
Published: January 2023

Wenchang (WC) chicken, the only indigenous chicken breed listed in Chinese genetic resources in Hainan province, is well known for its excellent meat quality and is sold all over southeast Asia. In recent years, the number of WC has decreased sharply with considerable variability in the quality at market. To explore the genetic diversity and population structure of WC chickens, the whole‐genome data of 235 WC individuals from three conservation farms were obtained using the Illumina 150 bp paired‐end platform and used in conjunction with the sequencing data from 123 individuals from other chicken breeds (including eight Chinese indigenous chicken breeds and three foreign or commercial breeds) downloaded from a public database. A total of 12 111 532 SNPs were identified, of which 11 541 878 SNPs were identified in WC. The results of gene enrichment analyses revealed that the SNPs harbored in WC genomes are mainly related to environmental adaptation, disease resistance and meat quality traits. Genetic diversity statistics, quantified by expected heterozygosity, observed heterozygosity, linkage disequilibrium, nucleotide diversity and fixation statistics, indicated that WC displays high genetic diversity compared with other Chinese indigenous chicken breeds. Genetic structure analyses showed that each population displayed great differentiation between WC and the other breeds, indicating the uniqueness of WC. In conclusion, the results of our study provide the first genomic overview of genetic variants, genetic diversity and population structure of WC from three conservation farms. This information will be valuable for the future breeding and conservation of WC and other surveyed populations.
Risk factors for persistent pain after breast cancer surgery: a multicentre prospective cohort study
Authors: Tan H. S. , Plichta J. K. , Kong A. , Tan C. W. , Hwang S. , Sultana R. , Wright M. C. , Sia A. T. H. , Sng B. L. , Habib A. S.
Published: January 2023

Identifying factors associated with persistent pain after breast cancer surgery may facilitate risk stratification and individualised management. Single‐population studies have limited generalisability as socio‐economic and genetic factors contribute to persistent pain development. Therefore, this prospective multicentre cohort study aimed to develop a predictive model from a sample of Asian and American women. We enrolled women undergoing elective breast cancer surgery at KK Women's and Children's Hospital and Duke University Medical Center. Pre‐operative patient and clinical characteristics and EQ‐5D‐3L health status were recorded. Pain catastrophising scale; central sensitisation inventory; coping strategies questionnaire‐revised; brief symptom inventory‐18; perceived stress scale; mechanical temporal summation; and pressure‐pain threshold assessments were performed. Persistent pain was defined as pain score ≥ 3 or pain affecting activities of daily living 4 months after surgery. Univariate associations were generated using generalised estimating equations. Enrolment site was forced into the multivariable model, and risk factors with p < 0.2 in univariate analyses were considered for backwards selection. Of 210 patients, 135 (64.3%) developed persistent pain. The multivariable model attained AUC = 0.807, with five independent associations: age (OR 0.85 95%CI 0.74–0.98 per 5 years); diabetes (OR 4.68, 95%CI 1.03–21.22); pre‐operative pain score at sites other than the breast (OR 1.48, 95%CI 1.11–1.96); previous mastitis (OR 4.90, 95%CI 1.31–18.34); and perceived stress scale (OR 1.35, 95%CI 1.01–1.80 per 5 points), after adjusting for: enrolment site; pre‐operative pain score at the breast; pre‐operative overall pain score at rest; postoperative non‐steroidal anti‐inflammatory drug use; and pain catastrophising scale. Future research should validate this model and evaluate pre‐emptive interventions to reduce persistent pain risk.
A case of supraventricular tachycardia misdiagnosis after dual‐chamber implantable cardioverter defibrillator implantation with His bundle pacing
Authors: Sun Xianchao , Huang Yue
Published: January 2023

The combined use of an implantable cardioverter defibrillator (ICD) and His bundle pacing (HBP) is believed to benefit patients with dilated cardiomyopathy (DCM) and atrial fibrillation but needs more guidance built on clinical experience. A patient who had an implanted dual‐chamber ICD with HBP presented to our hospital with DCM and atrial fibrillation. In the present case, the criteria for differential diagnosis were set as “if all,” which requires matching the morphological template, sudden onset, and interval stability. Ventricular tachycardia (VT) was misdiagnosed as supraventricular tachycardia due to morphological matching to sinus tachycardia. The misdiagnosis and mistaken VT treatment(ICD adaptive treatment) highlight the importance of personalized settings for differential diagnosis to avoid such a misdiagnosis or omission.
Analysis of serum microRNA‐122 in a randomized controlled trial of N‐acetylcysteine for treatment of antituberculosis drug‐induced liver injury
Authors: Moosa Muhammed Shiraz , Russomanno Giusy , Dorfman Jeffrey R. , Gunter Hannah , Patel Chandni , Costello Eithne , Carr Dan , Maartens Gary , Pirmohamed Munir , Goldring Christopher , Cohen Karen
Published: January 2023

Aim

Serum microRNA‐122 (miR‐122) is a novel biomarker for drug‐induced liver injury, with good sensitivity in the early diagnosis of paracetamol‐induced liver injury. We describe miR‐122 concentrations in participants with antituberculosis drug‐induced liver injury (AT‐DILI). We explored the relationship between miR‐122 and alanine aminotransferase (ALT) concentrations and the effect of N‐acetylcysteine (NAC) on miR‐122 concentrations.

Methods

We included participants from a randomized placebo‐controlled trial of intravenous NAC in AT‐DILI. ALT and miR‐122 concentrations were quantified before and after infusion of NAC/placebo. We assessed correlations between ALT and miR‐122 concentrations and described changes in ALT and miR‐122 concentrations between sampling occasions.

Results

We included 45 participants; mean age (± standard deviation) 38 (±10) years, 58% female and 91% HIV positive. The median (interquartile range) time between pre‐ and post‐infusion biomarker specimens was 68 h (47‐77 h). The median pre‐infusion ALT and miR‐122 concentrations were 420 U/L (238‐580) and 0.58 pM (0.18‐1.47), respectively. Pre‐infusion ALT and miR‐122 concentrations were correlated (Spearman's ρ = .54, P = .0001). Median fold‐changes in ALT and miR‐122 concentrations between sampling were 0.56 (0.43‐0.69) and 0.75 (0.23‐1.53), respectively, and were similar in the NAC and placebo groups (P = .40 and P = .68 respectively).

Conclusions

miR‐122 concentrations in our participants with AT‐DILI were considerably higher than previously reported in healthy volunteers and in patients on antituberculosis therapy without liver injury. We did not detect an effect of NAC on miR‐122 concentrations. Further research is needed to determine the utility of miR‐122 in the diagnosis and management of AT‐DILI.
VBAC calculator 2.0: Recent evidence
Authors: Thornton Patrick D.
Published: January 2023

Following criticism for the use of race as a biological predictor of vaginal birth after cesarean (VBAC), an updated version of the Society for Maternal‐Fetal Medicine (SMFM) VBAC calculator has been published. The variable “African American” or “Hispanic” (yes/no), which produced systematically lower chances of VBAC for nonwhites has been replaced with “chronic hypertension requiring treatment” (yes/no). Although there are no published external validation studies to date, developers report accuracy (area under the curve and calibration) nearly identical to the original calculator and it is published online for immediate use. This review examines the history of the calculator, measures of its validity, and recent studies measuring its performance among Hispanics, Blacks, Asians, and others with lower range scores. Underprediction of successful VBAC is evident in the original calculator, especially as predicted VBAC decreases. These studies raise a concern about the use of calculator scores in clinical management, that is, discouraging or restricting access to labor after cesarean (LAC) for parents with lower calculator scores. This raises special concern for minority populations who experience increased cesarean‐related morbidity, face obstacles accessing LAC care, and who may benefit disproportionately from increased LAC uptake. Although calculator developers have discouraged using calculator scores to restrict access to LAC, such uses are documented. It is not clear what effect the removal of race will have on calculator performance, and further study is required before calculator scores are used in counseling. This includes studies that include large numbers of low scoring and minority patients.
Interaction between nanomaterials and the innate immune system across evolution
Authors: Boraschi Diana , Canesi Laura , Drobne Damjana , Kemmerling Birgit , Pinsino Annalisa , Prochazkova Petra
Published: January 2023

Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno‐nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity is the first line of immune reactivity towards exogenous agents and is highly conserved throughout evolution, this review focuses on the major effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll‐like receptors (TLRs), for assessing the modes of successful versus pathological interaction between ENMs and host defences. By comparing the phagocyte‐ and TLR‐dependent responses to ENMs in plants, molluscs, annelids, crustaceans, echinoderms and mammals, we aim to highlight common recognition and elimination mechanisms and the general sufficiency of innate immunity for maintaining tissue integrity and homeostasis.
Rhegmatogenous retinal detachment surgery: A review
Authors: Warren Alexis , Wang Daniel W. , Lim Jennifer I.
Published: January 2023

Rhegmatogenous retinal detachment (RRD) is a serious surgical condition with significant ocular morbidity if not managed properly. Once untreatable, approaches to the repair of RRD have greatly evolved over the years, leading to outstanding primary surgical success rates. The management of RRD is often a topic of great debate. Scleral buckling, vitrectomy and pneumatic retinopexy have been used successfully for the treatment of RRD. Several factors may affect surgical success and dictate a surgeon's preference for the technique employed. In this review, we provide an overview and supporting literature on the options for RRD repair and their respective preoperative and postoperative considerations in order to guide surgical management.
Spontaneous recovery rate of idiopathic sudden sensorineural hearing loss: A systematic review and meta‐analysis
Authors: Chaushu Hen , Ungar Omer J. , Abu Eta Rani , Handzel Ophir , Muhanna Nidal , Oron Yahav
Published: January 2023

Purpose

Steroids comprise the mainstay of treatment for idiopathic sudden sensorineural hearing loss (ISSNHL). Since steroidal treatment was integrated to clinical practice guidelines, newly published no‐treatment or placebo arms in clinical trials are scarce. To evaluate the effectiveness of steroidal treatment ± hyperbaric oxygen therapy, the data should be compared to spontaneous recovery. The aim of this paper is to find the most accurate spontaneous recovery rate, in the light of which, other treatment modalities should be judged.

Materials and Methods

Eligible studies published until July 2021 were identified through systematic searches of ‘PubMed’, ‘Web of Science’ and ‘Google Scholar’. Retrospective studies and randomised/non‐randomised control trials involving only adult participants (≥18 years) with ISSNHL, and placebo/no treatment were included. Only articles that used the American Academy of Otolaryngology–Head and Neck Surgery's diagnostic criteria for ISSNHL were included.

Results

942 records initially identified, 166 duplicates and 753 articles were excluded based on article subject, title, and abstract. The full texts of 13 articles were reviewed. Seven studies were included for qualitative synthesis, five papers included in quantitative synthesis. 180 ears were included in pooled statistics. The pooled spontaneous recovery was 60.28% (95% confidence interval [CI] = 38.88%–79.94%) with a heterogeneity of 86.0% (95% CI = 69.4%–93.6%).

Conclusions

Spontaneous recovery of ISSNHL should not be over‐looked, as it may be close to 60%. This may have both clinical and research implications.
Uncovering the Structure of Semantic Representations Using a Computational Model of Decision‐Making
Authors: Ramotowska Sonia , Steinert‐Threlkeld Shane , van Maanen Leendert , Szymanik Jakub
Published: January 2023

According to logical theories of meaning, a meaning of an expression can be formalized and encoded in truth conditions. Vagueness of the language and individual differences between people are a challenge to incorporate into the meaning representations. In this paper, we propose a new approach to study truth‐conditional representations of vague concepts. For a case study, we selected two natural language quantifiers most and more than half. We conducted two online experiments, each with 90 native English speakers. In the first experiment, we tested between‐subjects variability in meaning representations. In the second experiment, we tested the stability of meaning representations over time by testing the same group of participants in two experimental sessions. In both experiments, participants performed the verification task. They verified a sentence with a quantifier (e.g., “Most of the gleerbs are feezda.”) based on the numerical information provided in the second sentence, (e.g., “60% of the gleerbs are feezda”). To investigate between‐subject and within‐subject differences in meaning representations, we proposed an extended version of the Diffusion Decision Model with two parameters capturing truth conditions and vagueness. We fit the model to responses and reaction times data. In the first experiment, we found substantial between‐subject differences in representations of most as reflected by the variability in the truth conditions. Moreover, we found that the verification of most is proportion‐dependent as reflected in the reaction time effect and model parameter. In the second experiment, we showed that quantifier representations are stable over time as reflected in stable model parameters across two experimental sessions. These findings challenge semantic theories that assume the truth‐conditional equivalence of most and more than half and contribute to the representational theory of vague concepts. The current study presents a promising approach to study semantic representations, which can have a wide application in experimental linguistics.
Abstracts of randomized controlled trials in the field of dentofacial trauma: Reporting quality and spin
Authors: Fang Xiaolin , Guo Feiyang , Chen Zhi , Hua Fang , Zhang Lu
Published: January 2023

Background/Aim

Abstracts of randomized controlled trials (RCTs) provide a summary of the entire trial report. Their transparent, detailed, and accurate reporting is essential for clinical decision‐making and evidence‐based dental practice. The aim of this study was to assess the reporting quality and prevalence of spin in abstracts of RCTs in the field of dentofacial trauma.

Materials and Methods

The PubMed database was searched to identify RCT reports published between 2017 and 2021 in the field of dentofacial trauma. The reporting quality of abstracts was assessed according to the 16‐item CONSORT for Abstracts checklist and measured with an overall quality score (OQS, range: 0–16). Linear regression analyses were used to identify factors associated with reporting quality. Among the included RCTs, parallel‐group RCTs with non‐significant primary outcomes were selected for spin assessment using predefined spin strategies.

Results

One hundred and twelve eligible abstracts were identified and included. The mean OQS was 4.51 (SD, 1.35; 95% CI, 4.26–4.76). Abstracts with more than 250 words (p = .004) and a structured format (p = .032) had significantly better reporting quality. Of the 30 abstracts that were eligible for spin assessment, spin was identified in 23 (76.7%). Among these, spin was observed in the Conclusions sections of 22 abstracts (73.3%) and the Results sections of 9 abstracts (30.0%).

Conclusions

Among RCT abstracts in the field of dentofacial trauma, the reporting quality was sub‐optimal and the prevalence of spin was relatively high. Strict adherence to the CONSORT for Abstracts guidelines is needed to ensure complete and transparent reporting. Relevant stakeholders need to make concerted efforts to avoid spin.
Social support buffers young men's resilient coping to psychological distress
Authors: Sharp Paul , Oliffe John L. , Kealy David , Rice Simon M. , Seidler Zac E. , Ogrodniczuk John S.
Published: January 2023

Aim

Social support and resilient coping can aid mental health. The aim of this study was to examine age effects of social support on men's resilient coping for psychological distress.

Methods

The sample consisted of 434 help‐seeking Canadian men who completed standardized measures. Regression analyses tested a moderated moderation model, controlling for COVID‐19 pandemic impact.

Results

Greater resilient coping was associated with lower psychological distress and this relationship was moderated by social support. Higher levels of social support had a significant positive effect on men's resilient coping for psychological distress. Findings indicated that younger men (18–24 years) were most positively buffered by social support.

Conclusions

Social support appears to be particularly important for young men's coping response to psychological distress. This is an important finding in the context of the COVID‐19 pandemic, where social support networks have been challenged. Community‐based and clinical programs and initiatives that proactively target young men's development of social connections and robust supportive networks, while bolstering their individual resilient coping skills, are likely to provide protections from psychological distress.
Dominant temperate and subalpine Japanese trees have variable photosynthetic thermal optima according to site mean annual temperature
Authors: Kobayashi Yuta , Haga Chihiro , Shinohara Naoto , Nishizawa Keita , Mori Akira S.
Published: January 2023

Aim

Global flux data analyses have shown a significant positive and linear relationship between site‐scale photosynthetic optimum temperature (Topt‐s) and averaged temperature variables. However, as existing studies have not fully considered species composition, it remains unclear to what extent the change in Topt‐s is derived from intraspecific plasticity or from a difference in species with a consistent species‐specific Topt‐s. We tested these two hypotheses using the satellite‐derived enhanced vegetation index (EVI).

Location

Subalpine and temperate forests in Japan.

Time period

2001–2020.

Major taxa studied

Thirty‐three tree species.

Methods

Based on an in situ vegetation survey dataset, we identified 1814 EVI cells (250 m × 250 m) that were characteristic of the spectral reflectance of a single dominant species. For each cell, we pooled EVIs from 2001 to 2020 and estimated the temperature at the time of EVI peak as a species‐specific Topt‐s. We tested our hypotheses by fitting linear regression models to the Topt‐s and mean annual temperature (MAT). A positive slope indicated support for the intraspecific plasticity hypothesis.

Results

For 32 of the 33 tree species, the Topt‐s increased with an increase in MAT. A linear mixed‐effect model provided a good explanation of the variation in the Topt‐s based on the MAT (intercept = 14.63, slope = 0.58, marginal R2 = .78), with minimal effect of species difference (conditional R2 = .75).

Main conclusions

Our results support the intraspecific plasticity hypothesis. At least in East Asian subalpine and temperate forests, the Topt‐s can be estimated from the MAT, irrespective of the dominant canopy species. The observed MAT–Topt‐s relationship is consistent with the findings of previous photosynthetic studies and has important implications for the establishment of new algorithms for estimating gross primary productivity that can account explicitly for spatial and temporal differences in temperature‐dependent photosynthetic responses.
Greasing the wheels of policy reversal: Discursive engineering and public opinion management during the relaxation of China's family planning policy
Authors: Yan Xiaojun , Li La
Published: January 2023

How do autocratic regimes use political propaganda to facilitate policy reversals of major significance? In this article, we demonstrate how the authoritarian regime in China dynamically uses propaganda to accomplish rapid discursive shifts in the context of major policy changes. Using a structural topic model for unsupervised machine learning to analyze extensive propaganda materials, we explore how the Chinese Communist Party facilitated the reversal of its One‐Child Policy in 2015 by deploying a systematic, precise, multi‐dimensional, and multi‐layered discursive engineering project. Our findings demonstrate that instead of a monolithic and rigid operation, China's state propaganda is a strategic and flexible discursive engineering project tailored to contingent factors, such as the nature of the policy being advocated, the level of the propaganda venue, and the needs, mentality, and tastes of carefully targeted audiences. This coordinated maneuver of state narrative is key for the effective and smooth policy reversal of major significance.
Cross‐sectional study evaluating the association of haemophilia‐related distress and clinically relevant outcomes
Authors: Guasch Sara , Scott Lia C. , Figueroa Janet , Buckner Tyler W. , Mattis Shanna , Tran Duc Q. , Kempton Christine L.
Published: January 2023

Introduction

In chronic diseases, disease‐related distress can impact disease outcomes. Distress and haemophilia‐related distress has been demonstrated in people with haemophilia (PwH). The association of haemophilia‐related distress on disease outcomes among PwH is unknown.

Aim

To study the association of haemophilia‐related distress with haemophilia specific outcomes, including adherence to prophylactic therapy, the presence of a target joint, healthcare utilization and work‐impairment.

Methods

In a cross‐sectional study, adults with haemophilia A or B were enrolled in a study to validate the haemophilia‐related distress questionnaire (HRDq). In this planned analysis, univariate and multivariate associations between the HRDq total score and disease outcomes were explored.

Results

The 114 participants in this analysis were male, mostly with haemophilia A (92%) and severe disease (52%) with a median age of 31.9 years. On univariate analysis, HRDq total score (5‐point change) was associated with the presence of a target joint (P = .002), high healthcare utilization (P = .011), poor adherence (P = .033) and work‐impairment (P ≤ .001). After adjustment for age, race, severity and other potential confounders, adherence (aβ 0.33, 95% CI .17, .49) and work‐impairment (aβ 4.69, 95% CI 3.27‐6.1) remained statistically significantly associated with HRDq total score.

Conclusion

Haemophilia‐related distress is associated with poor adherence to factor prophylaxis and work‐impairment. The direction of the association (causation) is yet to be determined and requires future study.
Access to novel drugs and therapeutics for children and youth: Eliciting citizens' values to inform public funding decisions
Authors: Gauvreau Cindy L. , Wight Lisa , Subasri Mathushan , Palmer Antonia , Hayeems Robin , Croker Alysha , Abelson Julia , Fraser Brent , Bombard Yvonne , Moore Hepburn Charlotte , Wilson Michael G. , Denburg Avram
Published: January 2023

Introduction

The unique evidentiary, economic and ethical challenges associated with health technology assessment (HTA) of precision therapies limit access to novel drugs and therapeutics for children and youth, for whom such challenges are amplified. We elicited citizens' perspectives about values‐based criteria relevant to the assessment of paediatric precision therapies to inform the development of a child‐tailored HTA framework.

Methods

We held four citizen panels virtually in May–June 2021, informed by a plain‐language citizen brief summarizing global and local evidence about the challenges, policy and programmatic options and implementation strategies related to enhancing access to precision therapies for Canadian children and youth. Panellists were recruited through a nationally representative database, medical/patient networks and social media. We inductively coded and thematically analysed panel transcripts to generate themes and identify priority values.

Results

The perspectives of panellists (n = 45) coalesced into four overlapping themes, with attendant subthemes, relevant to a child‐tailored HTA framework: (1) Childhood Distinctions: vulnerability, ‘fair innings’, future potential, family impacts; (2) Voice: agency of children and youth; lived versus no lived experience; (3) One versus Many: disease severity, rarity, equity, unmet need and (4) Health System Governance: funding, implementation inequities, effectiveness and safety. Participants broadly agreed that childhood distinctions, particularly family impacts, justify child‐tailored HTA. Dissent arose over whose voice should inform HTA and how such perspectives are best incorporated.

Conclusions

Citizens can offer unique insights into criteria relevant to the development or revision of HTA frameworks to capture holistic, societally responsive dimensions of value attached to unique contexts or populations, including children. Balancing the hopes and expectations of patients and caregivers for access to expensive but potential life‐altering therapies against the opportunity costs borne by encompassing health systems is a fundamental challenge that will require rigorous methods to elicit, weigh and reconcile varied views.

Patient or Public Contribution

A patient advocate served on the steering committee of this study and co‐authored this article. Key informants for the Citizen Brief included patient advocates and caregivers; a separate patient advocate reviewed the Brief before dissemination. Qualitative and quantitative data were collected from the general public and caregivers of children, with written consent.
Exploring COVID‐19 experiences for persons with multiple sclerosis and carers: An Australian qualitative study
Authors: Correia Helen , Martin‐Lynch Pamela , Finlayson Marcia , Learmonth Yvonne C.
Published: January 2023

Objective

The COVID‐19 pandemic continues to impact communities around the world. In this study, we explored the COVID‐19 experiences of persons with multiple sclerosis (MS) and carers.

Methods

Using a qualitative approach, interviews were undertaken with 27 participants residing in Australia (10 persons with MS, 10 carers and 7 MS service providers). Demographic and background data were also collected. Interviews were analysed using an inductive iterative thematic analysis.

Results

Across all groups, participants consistently recognized pandemic challenges and impacts for persons with MS and carers, especially due to disruption to routines and services. Emotional and mental health impacts were also highlighted, as anxiety, fear of contracting COVID‐19 and stress, including relationship stress between persons with MS and carers and family members. Some persons with MS also mentioned physical health impacts, while for carers, the challenge of disruptions included increased demands and reduced resources. In addition to acknowledging challenges, persons with MS and carers also gave examples of resilience. This included coping and adapting by finding new routines and creating space through rest and breaks and through appreciating positives including the benefits of access to telehealth.

Conclusion

Additional support is required for persons with MS and carers in navigating the impacts of COVID‐19 as the pandemic progresses. In addition to addressing challenges and disruptions, such support should also acknowledge and support the resilience of people with MS and carers and enhance resilience through supporting strategies for coping and adaptation.

Patient and Public Contribution

Service user stakeholders were consulted at the beginning and end of the study. They provided feedback on interview questions and participant engagement, as well as service user perspectives on the themes identified in the current study. Participants were provided with summaries of key themes identified and invited to provide comments.
The impact of climate change on atopic dermatitis and mental health comorbidities: a review of the literature and examination of intersectionality
Authors: Kam Sharon , Hwang Barrington J. , Parker Eva R.
Published: January 2023

Climate change, fueled by increasing concentrations of greenhouse gases, is associated with rising temperatures, extreme weather events, increased aeroallergen production, and air pollution. Our understanding that many inflammatory cutaneous diseases carry important mental health comorbidities is expanding. Simultaneously, the detrimental impacts of climate change on human health are now widely recognized as a global public health crisis. Importantly, these climate‐associated phenomena exacerbate the environmental triggers of atopic dermatitis (AD) and are also associated with amplification of comorbid mental health conditions in AD including depression, anxiety, trauma‐related disorders, and psychotic spectrum disorders. This review is the first to examine the nexus of climate change, atopic dermatitis, and mental health comorbidities and emphasizes the disproportionate impacts of climate change in vulnerable and marginalized populations.
Soluble programmed death ligand‐1‐induced immunosuppressive effects on chimeric antigen receptor‐natural killer cells targeting Glypican‐3 in hepatocellular carcinoma
Authors: Chen Lin , Liu Siyuan , Adah Dickson , Sun Qingyang , Liang Zhaoduan , Ho Mitchell , Sun Beicheng
Published: January 2023

Although the pre‐clinical study of chimeric antigen receptor (CAR)‐natural killer (NK) cell was effective against various tumours, immunosuppression mediated by tumour microenvironment hampers their application and several efforts have been explored to improve their effect in combating solid tumours. Glypican 3 (GPC3) is a promising target for hepatocellular carcinoma (HCC), and CAR‐T cells targeting GPC3 have been tested in clinical trials. Based on an affinity‐enhanced antibody (hYP7) targeting GPC3, we constructed GPC3‐CAR‐NK cells to explore their potential function in the treatment of HCC. We found that patients with HCC secreted high levels of soluble programmed death‐ligand 1 (sPD‐L1), which inhibits the function of CAR‐NK cells targeting GPC3. In addition, we combined high‐affinity sPD‐L1 variant (L3C7c‐Fc) with GPC3‐CAR‐NK cells to solve the problem of GPC3‐CAR‐NK inhibition. Our studies demonstrated that L3C7c‐Fc could enhance the therapeutic effect of CAR‐NK cells by reversing the suppression of sPD‐L1, which provides the experimental evidence for the subsequent development of HCC immunotherapy strategies.
How to introduce a livestreaming channel: a case of the hotel at a fixed capacity
Authors: Guo Qiang , Cheng Shengyan , Zhao Pengfei
Published: January 2023

Considering two hotels that sell substitutable rooms through the same online travel agency (OTA), we study the optimal supply chain structure for a fixed‐capacity hotel to introduce a livestreaming channel (LC). First, ideal pricing and room allocation are explored through four scenarios: (a) a single channel with no introduction, (b) a dual channel with a hotel‐operated LC, (c) a dual channel with an OTA‐operated LC, and (d) a dual channel involving an influencer retailer. Upon comparing each model's supply chain performance, we find that small and large hotels prefer influencer retailers, while medium‐sized hotels favor a self‐operated LC when influencers cannot demonstrably extend the market. An OTA‐operated livestreaming service is only appropriate for a declining economy because the platform's reputation and livestream presentation can inform consumers’ travel intentions after recovery. Furthermore, OTAs may only suffer during the introductory period, whereas a supply chain system will benefit from celebrities’ charisma and impulsive consumption.