bluuebunny/crossref_metadata_2025 huggingface dataset:
The clinical significance of emotional urgency in bipolar disorder: a scoping review
Authors: Teh Wen Lin , Si Sheng Yeow , Liu Jianlin , Subramaniam Mythily , Ho Roger
Published: May 2024

Background

Emotional urgency, defined as a trait concept of emotion-based impulsivity, is at least moderately associated with general psychopathology. However, its clinical significance and associations with clinically relevant features of bipolar disorder remain unclear. This scoping review aims address this gap by determining the extent of evidence in this niche scope of study.

Methods

Evidence of between-group differences of positive and negative urgency, its associations with mood severity, and all peripheral associations related to illness and psychosocial outcomes were synthesized based on PRISMA checklists and guidelines for scoping reviews (PRISMA-ScR).

Design

Electronic databases were searched for articles published between January 2001 and January 2024. A total of 1013 entries were gathered, and a total of 10 articles were included in the final selection after the removal of duplicates and ineligible articles.

Results

Differences in urgency scores between bipolar disorder and healthy controls were large (Cohen’s d ranged from 1.77 to 2.20). Negative urgency was at least moderately associated with overall trauma, emotional abuse, neglect, suicide ideation, neuroticism, and irritable/cyclothymic temperament, whereas positive urgency was at least moderately associated with various aspects of aggression and quality of life. Positive but not negative urgency was associated with quality of life in bipolar disorder.

Conclusion

Large between-group differences found for emotional urgency in bipolar disorder imply large clinical significance. Emotional urgency was associated with worse clinical features and outcomes. Given the high clinical heterogeneity of the disorder, emotional urgency may be an important phenotype indicative of greater disorder severity.
Assessment of immediate and five-year earthquake impacts on river systems in sabah, Malaysia using multi-temporal satellite imageries
Authors: Chai Lee Ting , Nainar Anand , Roslee Rodeano , Wong Wilson Vun Chiong , Phua Mui-How
Published: May 2024

Background

Earthquake is one of the most destructive natural disasters, which cause immediate and long-term changes to the river systems. This research aimed to examine the immediate and five-year impacts of the 2015 Ranau Earthquake (6.0 Mw) on river systems in Malaysian state of Sabah, a region of low earthquake hazard.

Methods

We used object-based classification on Landsat 8 (2014 and 2015) and Sentinel-2A (2020) satellite imageries to derive land cover time series for investigating the impacts on the riparian areas.

Results

The earthquake removed vegetation in the riparian zones of four rivers, the highest being the Penataran River (69.21 ha). During the immediate impact period (2014–2015), river bar formation occurred in all rivers, with the largest increase occurring in the Kadamaian River (56.97 ha), followed by the Panataran River (54.36 ha), which had no river bar before the earthquake. The river bar of the Kadamaian River continued to increase, whereas the river bar of the Panataran River decreased five years after the earthquake. Land cover transition analysis revealed that 78.39 ha of vegetation, barren land, and river water areas changed to river bars in the Kadamaian riparian area during the immediate impact period. Except for 26.87% of river bars in the Kadamaian riparian area in 2015, most river bars transitioned to other land cover types five years later. During the period of immediate impact, 22.05 ha of vegetation and 10.71 ha of river water were transformed into river bars along the Penataran River. Five years later, except for 16.2 ha, all river bar areas had transitioned to other cover types. Additionally, 17.7 ha of new river bars were formed. This study provides crucial data on post-earthquake land cover changes, particularly river bar formation and changes, for assessing the earthquake impacts on the river systems and supporting impact mitigation.
Research on re-searching: interrupted foraging is not disrupted foraging
Authors: Hong Injae , Wolfe Jeremy M.
Published: May 2024

In classic visual search, observers typically search for the presence of a target in a scene or display. In foraging tasks, there may be multiple targets in the same display (or “patch”). Observers typically search for and collect these target items in one patch until they decide to leave that patch and move to the next one. This is a highly rule-governed behavior. The current study investigated whether these rules are disrupted when the foraging is interrupted in various manners. In Experiment 1, the foraging was briefly interrupted and then resumed in the same patch. In Experiments 2 and 3, the foraging in each patch either ended voluntarily or compulsorily after a fixed amount of time. In these cases, foraging resumed in a patch only after all patches were visited. Overall, the rules of foraging remained largely intact, though Experiment 2 shows that foraging rules can be overridden by the demand characteristics of the task. The results show that participants tended to perform approximately consistently despite interruptions. The results suggest that foraging behavior in a relatively simple foraging environment is resilient and not easily disrupted by interruption.
Estimating the volume of penumbra in rodents using DTI and stack-based ensemble machine learning framework
Authors: Kuo Duen-Pang , Chen Yung-Chieh , Li Yi-Tien , Cheng Sho-Jen , Hsieh Kevin Li-Chun , Kuo Po-Chih , Ou Chen-Yin , Chen Cheng-Yu
Published: May 2024

Background

This study investigates the potential of diffusion tensor imaging (DTI) in identifying penumbral volume (PV) compared to the standard gadolinium-required perfusion–diffusion mismatch (PDM), utilizing a stack-based ensemble machine learning (ML) approach with enhanced explainability.

Methods

Sixteen male rats were subjected to middle cerebral artery occlusion. The penumbra was identified using PDM at 30 and 90 min after occlusion. We used 11 DTI-derived metrics and 14 distance-based features to train five voxel-wise ML models. The model predictions were integrated using stack-based ensemble techniques. ML-estimated and PDM-defined PVs were compared to evaluate model performance through volume similarity assessment, the Pearson correlation analysis, and Bland–Altman analysis. Feature importance was determined for explainability.

Results

In the test rats, the ML-estimated median PV was 106.4 mL (interquartile range 44.6–157.3 mL), whereas the PDM-defined median PV was 102.0 mL (52.1–144.9 mL). These PVs had a volume similarity of 0.88 (0.79–0.96), a Pearson correlation coefficient of 0.93 (p < 0.001), and a Bland–Altman bias of 2.5 mL (2.4% of the mean PDM-defined PV), with 95% limits of agreement ranging from -44.9 to 49.9 mL. Among the features used for PV prediction, the mean diffusivity was the most important feature.

Conclusions

Our study confirmed that PV can be estimated using DTI metrics with a stack-based ensemble ML approach, yielding results comparable to the volume defined by the standard PDM. The model explainability enhanced its clinical relevance. Human studies are warranted to validate our findings.

Relevance statement

The proposed DTI-based ML model can estimate PV without the need for contrast agent administration, offering a valuable option for patients with kidney dysfunction. It also can serve as an alternative if perfusion map interpretation fails in the clinical setting.

Key points

• Penumbral volume can be estimated by DTI combined with stack-based ensemble ML.

• Mean diffusivity was the most important feature used for predicting penumbral volume.

• The proposed approach can be beneficial for patients with kidney dysfunction.

Graphical Abstract
Benefits and advances of Cone Beam CT use in prostatic artery embolization: review of the literature and pictorial essay
Authors: Rostambeigi Nassir , Crawford Daniel , Golzarian Jafar
Published: May 2024

Prostatic artery embolization (PAE) has proven to be an efficacious treatment for urinary symptoms of benign prostatic hyperplasia. PAE is performed in a complex and challenging anatomical field which may pose difficulties from procedural standpoint. Cone beam computed tomography (CBCT) has been proposed as an invaluable tool during the PAE procedure. A review of different techniques and advancements, as well as demonstration of CBCT benefits via a pictorial overview of the salient examples is lacking. The techniques of CBCT are discussed herein and the virtual injection technology as an advancement in CBCT is discussed. To show the merits of CBCT in PAE, a pictorial overview of various clinical scenarios is presented where CBCT can be crucial in decision making. These scenarios are aimed at showing different benefits including identification of the origin of the prostatic artery and avoiding non-target embolization. Other benefits may include ensuring complete embolization of entire prostate gland as angiographic appearance alone can be inconclusive if it mimics a severely thickened bladder wall or ensuring adequate embolization of the median lobe to provide relief from “ball-valve” effect. Further examples include verification of embolization of the entire prostate when rare variants or multiple (> 2) arterial feeders are present.
Unintentionally intentional: unintended effects of spinal stimulation as a platform for multi-modal neurorehabilitation after spinal cord injury
Authors: Moreno Romero Gerson N. , Twyman Avery R. , Bandres Maria F. , McPherson Jacob Graves
Published: May 2024

Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement, reducing symptoms of autonomic dysreflexia, improving functions mediated by muscles of the pelvic floor (e.g., bowel, bladder, and sexual function), reducing spasms and spasticity, and decreasing neuropathic pain, among others. This diverse set of actions is related both to the density of sensorimotor neural networks in the spinal cord and to the intrinsic ability of electrical stimulation to modulate neural transmission in multiple spinal networks simultaneously. It also suggests that certain spinal stimulation parameterizations may be capable of providing multi-modal therapeutic benefits, which would directly address the complex, multi-faceted rehabilitation goals of people living with spinal cord injury. This review is intended to identify and characterize reports of spinal stimulation-based therapies specifically designed to provide multi-modal benefits and those that report relevant unintended effects of spinal stimulation paradigms parameterized to enhance a single consequence of spinal cord injury.
Sonographic evaluation of peripheral nerve involvement in leprosy with electrophysiologic correlation: a cross-sectional study in sub-Himalayan region
Authors: Aggarwal Neeti , Thakur Pooja , Kapila Sumala , Thakur Shruti , Jhobta Anupam , Makhaik Sushma , Thakur Charu Smita
Published: May 2024

Background

Leprosy is an age-old chronic infectious disease with the majority of annual new case detections from South-East Asia. The disease manifestations coupled with the stigma attached to it often creates grave socioeconomic problems. Leprosy is curable and if detected and treated in the early stages can prevent disability. Ultrasonography provides information regarding location and degree of the nerve damage, nerve morphologic alterations, echo texture, fascicular pattern and vascularity. The aim of this study was to study the ultrasonographic features of neuropathy in leprosy with electrophysiologic correlation.

Results

A total of 34 histopathological proven cases of leprosy were included in this study, which was conducted for 1 year. High-resolution ultrasound (HRUS) of a total of 204 peripheral nerves in these 34 patients, including bilateral ulnar, median and common peroneal nerves, was performed. Cross-sectional areas, nerve diameters, nerve morphology and vascularity were noted and correlated with electrophysiologic study of these nerves. The results showed that all the patients having reduced motor or sensory function [decreased compound muscle action potential (CMAP), decreased compound nerve action potential (SNAP) and increased latency] in ulnar and common peroneal nerves were thickened on HRUS (100% in ulnar and common peroneal nerves) while 92% right median and 89% left median nerves with reduced motor or sensory function showed thickening on HRUS. Also, 5.8% ulnar nerves and 11.7% common peroneal nerves showed thickening on HRUS; however, sensory or motor conduction of these nerves was unaffected on nerve conduction study (NCS). So, a positive correlation was observed for nerve involvement as detected by ultrasonographic findings of nerve hypertrophy and the electrophysiologic study. The most common finding was focal or diffuse nerve thickening. Ulnar nerve was the most commonly thickened nerve in leprosy patients with the most common location of nerve thickening at medial epicondyle.

Conclusions

Ultrasound and electrophysiologic study of peripheral nerves in leprosy are complimentary to each other in diagnosing leprotic neuropathy.
The status of ultrasound imaging education in Doctor of Physical Therapy program curricula: results of a national survey
Authors: Savage Nathan J. , Condo Matthew , Hodges Nicole
Published: May 2024

Background

This investigation evaluated the state of ultrasound imaging (USI) education in entry-level Doctor of Physical Therapy (DPT) program curricula in the USA, including faculty perceptions and qualifications regarding USI and identification of potential barriers to inclusion or expansion of USI education. A review of published literature reveals that the inclusion of USI education in entry-level DPT program curricula has not been systematically investigated and is largely unknown.

Methods

Investigators created an online survey developed in QualtricsXM and distributed through email an electronic link to the program chair/director at all 258 accredited entry-level DPT programs in the USA with instructions to complete and or share with faculty.

Results

The overall response rate was 24% (65/269) and represented 54 programs from 28 of the 50 states; 70% reported including USI education in their program’s curriculum, with 91% spending < 10 h on instruction throughout their curriculum; 44% reported plans to expand USI education in their curriculum, with 85% citing expanding scope of practice and curriculum as primary reasons; 79% cited the lack of qualified instructors, lack of knowledge/training, and equipment cost as the largest barriers to the inclusion of USI education in their program’s curriculum. Whether USI is an entry-level skill was evenly split among respondents.

Conclusions

Respondents from a representative sample of entry-level DPT programs across the USA provided survey responses. Despite most respondents being knowledgeable about USI, most do not use this point-of-care imaging modality in clinical practice. Based on the results of this survey, overcoming perceived barriers is necessary to expand USI education in entry-level DPT program curricula, namely, lack of qualified instructors, lack of knowledge/training, and cost of equipment. This national survey provides original data that may stimulate discussion about innovative ways to include USI education in entry-level DPT program curricula to meet the emerging needs of our profession.
Optimization of porosity behavior of hybrid reinforced titanium metal matrix composite through RSM, ANN, and GA for multi-objective parameters
Authors: Gemeda Birhane Assefa , Sinha Devendra Kumar , Mengesha Getinet Asrat , Gautam Satyam Shivam
Published: May 2024

Titanium matrix composites (TMCs) have high specific strength and stiffness, and high-temperature TMCs can reduce weight by up to 50% when compared with monolithic super alloys while preserving equal stiffness and strength in jet engine systems for propulsion. The purpose of this work examines the use of mathematical models and learning approaches to optimize response such as porosity and control variables in synthesized hybrid titanium metal matrix composites (HTMMCs) reinforced by B4C-SiC-MoS2-ZrO2. To further understand the impacts of process factors on porosity reduction, the study employs methodologies such as the response surface methodology (RSM), integrated artificial neural networks (ANN), and genetic algorithm (GA). The findings indicate that these strategies have the potential to contribute to the industry. The optimal combination of 7.5wt.% SiC, 7.5wt.% B4C, 7.5wt.% ZrO2, 4wt.% MoS2, and 73.5wt.% Ti compositions was determined utilizing process factors such as milling period (6h), compaction pressure (50MPa), compact duration (50min), sintering temperature (1200°C), and sintering time (2h) as compared to pure Ti grade 5. The mechanical properties of the optimum combination of reinforcement weight percentage and process parameters resulted in a minimum porosity of 0.118%, density of 4.36gcm3, and micro-hardness of 63.4HRC boosted by 1.76%, and compressive strength of 2500MPa increased by 2.6%. In addition, these HTMMCs had a minimal wear rate of 0.176mm3/Nm and a corrosion resistance rate of 2.15×10-4mmpy. The investigation result analysis discovered that the RSM and combined ANN-GA models considerably enhanced the forecasting of multidimensional interaction difficulties in composite material production that were highly statistically connected, with R2 values of 0.9552 and 0.97984. The ANN-GA model provided a 95% confidence range for porosity predictions, which increased the production use of titanium-based particle composites. Furthermore, HMMCs can be utilized in the automotive and aviation industries with enhanced corrosion and wear resistance.
Large-scale 3D inversion of semi-airborne electromagnetic data — Topography and induced polarization effects in a graphite exploration scenario
Authors: Mörbe Wiebke , Yogeshwar Pritam , Tezkan Bülent , Kotowski Philipp , Thiede Anneke , Steuer Annika , Rochlitz Raphael , Günther Thomas , Brauch Klaus , Becken Michael
Published: May 2024

The transition toward renewable energies demands a secure supply of critical raw materials and requires efficient noninvasive methods for deep earth resource exploration. The novel, deep electromagnetic (EM) sounding for the mineral exploration semi-airborne EM (semi-AEM) exploration concept aims at the efficient exploration of resources down to a depth of 1 km. Here, we evaluate a large-scale semi-AEM exploration study in a graphite mining district in eastern Bavaria, Germany. The derived 3D semi-AEM model is based on approximately 70,000 complex-valued data points recorded using seven transmitters. Strong conductivity contrasts with dominant east–west-trending anomalies are visible. Shallow high-conductivity structures correlate well with the known occurrence of graphite and match existing helicopter-borne EM results. The main anomaly reaches down to several hundred meters depth. To investigate different interpretation scenarios for large-scale semi-AEM data, we determine the effect of topography and analyze the feasibility of fast 2D inversion applications. To validate the robustness of the 3D semi-AEM model, the data set is inverted with two different 3D inversion algorithms and the results are compared. The presence of graphite leads to significant induced polarization (IP) effects with considerably high chargeabilities superposing EM induction. We include these effects in a realistic 3D inversion using a synthetic data study to analyze if the IP effect alters the overall conductivity structure and demonstrate that the obtained 3D model is reliable.
Intimate Care Products and Incidence of Hormone-Related Cancers: A Quantitative Bias Analysis
Authors: O'Brien Katie M. , Wentzensen Nicolas , Ogunsina Kemi , Weinberg Clarice R. , D'Aloisio Aimee A. , Edwards Jessie K. , Sandler Dale P.
Published: May 2024

PURPOSE

Intimate care products may contain substances associated with increased risk of hormone-related cancers. The relationship between genital talc use and ovarian cancer, in particular, has been well studied, but concerns about recall bias and exposure misclassification have precluded conclusions. We examined the association between intimate care products and female hormone–related cancers, accounting for potential biases, using data from a US-based cohort study.

METHODS

The Sister Study enrolled 50,884 women who had a sister with breast cancer. Data on genital talc use and douching were collected at enrollment (2003-2009) and follow-up (2017-2019). We used Cox proportional hazards models to estimate hazard ratios (HRs) for associations between intimate care product use and breast, ovarian, and uterine cancers. To account for potential exposure misclassification and recall bias, we conducted quantitative bias analyses under various exposure reassignment assumptions.

RESULTS

Across considered scenarios, 41%-64% of participants douched and 35%-56% used genital talc. In models adjusted for exposure misclassification, genital talc use was positively associated with ovarian cancer (HR range, 1.17-3.34) Frequent douching and douching during young adulthood were positively associated with ovarian cancer, but neither douching nor talc was associated with breast or uterine cancer. Differential reporting of talc use by cases and noncases likely produces positive biases, but correcting for error still resulted in HRs above 1.0. For example, HR, 1.40 (95% CI, 1.04 to 1.89) when 25% of exposed cases and 10% of unexposed noncases had talc status reassigned.

CONCLUSION

Although results show how differential recall would upwardly bias estimates, corrected results support a positive association between use of intimate care products, including genital talc, and ovarian cancer.
Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With ERBB2/3 Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study
Authors: Cannon Timothy L. , Rothe Michael , Mangat Pam K. , Garrett-Mayer Elizabeth , Chiu Vi K. , Hwang Jimmy , Vijayvergia Namrata , Alese Olatunji B. , Dib Elie G. , Duvivier Herbert L. , Klute Kelsey A. , Sahai Vaibhav , Ahn Eugene R. , Bedano Pablo , Behl Deepti , Sinclair Sarah , Thota Ramya , Urba Walter J. , Yang Eddy S. , Grantham Gina N. , Hinshaw Dominique C. , Gregory Abigail , Halabi Susan , Schilsky Richard L.
Published: May 2024

PURPOSE

Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer and genomic alterations known to be drug targets. Results of a cohort of patients with biliary tract cancer (BTC) with ERBB2/3 amplification, overexpression, or mutation treated with pertuzumab plus trastuzumab are reported.

METHODS

Eligible patients had advanced BTC, measurable disease (RECIST v1.1), Eastern Cooperative Oncology Group performance status 0-2, adequate organ function, tumors with ERBB2/3 alterations, and a lack of standard treatment options. Simon's two-stage design was used with a primary end point of disease control (DC), defined as objective response (OR) or stable disease of at least 16+ weeks duration (SD16+) according to RECIST v1.1. Secondary end points included OR, progression-free survival, overall survival, duration of response, duration of stable disease, and safety.

RESULTS

Twenty-nine patients were enrolled from February 2017 to January 2022, and all had advanced BTC with an ERBB2/3 alteration. One patient was not evaluable for efficacy. One complete response, eight partial responses, and two SD16+ were observed for DC and OR rates of 40% (90% CI, 27 to 100) and 32% (95% CI, 16 to 52), respectively. The null hypothesis of 15% DC rate was rejected ( P = .0015). Four patients had at least one grade 3 adverse event (AE) or serious AE at least possibly related to treatment: anemia, diarrhea, infusion-related reaction, and fatigue.

CONCLUSION

Pertuzumab plus trastuzumab met prespecified criteria to declare a signal of activity in patients with BTC and ERBB2/3 amplification, overexpression, or mutation.
Scoping Review of Barriers and Facilitators to Recruitment of Black People With Cancer in Biospecimen-Based Research
Authors: Morris Hayley N. , Winslow Ashlee Taylor , Barreiro-Rosado Jeenn Alain , Torian Stacy , Charlot Marjory
Published: May 2024

The increasing focus on precision medicine to optimize cancer treatments and improve cancer outcomes is an opportunity to consider equitable engagement of people racialized as Black or African American (B/AA) in biospecimen-based cancer research. B/AA people have the highest cancer incidence and mortality rates compared with all other racial and ethnic groups in the United States, yet are under-represented in biospecimen-based research. A narrative scoping review was conducted to understand the current literature on barriers, facilitators, and evidence-based strategies associated with the engagement of B/AA people with cancer in biospecimen research. Three comprehensive searches of MEDLINE, CINAHL, Embase, and Scopus were conducted. Of 770 studies generated by the search, 10 met all inclusion criteria for this review. The most frequently reported barriers to engagement of B/AA people in biospecimen research were lack of biospecimen research awareness, fear of medical harm, and violation of personal health information privacy, resource constraints, and medical mistrust. Key facilitators included previous exposure to research, knowledge about underlying genetic causes of cancer, and altruism. Recommended strategies to increase participation of B/AA people in biospecimen-based research included community engagement, transparent communication, workforce diversity, education and training, and research participant incentives. Inclusion of B/AA people in biospecimen-based research has the potential to advance the promise of precision oncology for all patients and reduce racial disparities in cancer outcomes.
Using the Cell-Cycle Risk Score to Predict the Benefit of Androgen-Deprivation Therapy Added to Radiation Therapy in Patients With Newly Diagnosed Prostate Cancer
Authors: Tward Jonathan D. , Lenz Lauren , Gutin Alexander , Clegg Wyatt , Kasten Chelsea R. , Finch Robert , Cohen Todd , Michalski Jeff , Kishan Amar U.
Published: May 2024

PURPOSE

Guidelines recommend adding androgen-deprivation therapy (ADT) to radiation therapy (RT) in certain patients with localized prostate cancer. Individualized genomic testing may improve the prognostic accuracy of risk assessments. Herein, we describe a mathematical model of the benefit of adding ADT to RT as a function of the personalized clinical cell-cycle risk (CCR) score to inform 10-year metastasis risk.

METHODS

A model of absolute risk reduction (ARR) was built using a retrospective cohort of men tested with Prolaris who received RT alone (N = 467). The relative benefit of ADT added to RT to reduce distant metastasis was estimated at 41% on the basis of a meta-analysis of randomized trials. The ARR and number needed to treat (NNT) were computationally derived in patients clinically tested with Prolaris between January 1, 2020, and October 31, 2022 (N = 56,485). Risks were predicted using a cause-specific Cox proportional hazards model with CCR score predicting time to metastasis. A CCR score of 2.112 represents the validated multimodal treatment (MMT) threshold.

RESULTS

The ARR from ADT increased from almost zero at low CCR scores to 17.1% at CCR = 3.690 with the corresponding NNT = 6, indicating that adding ADT to RT would prevent metastasis within 10 years for one of every six treated individuals. In the clinical cohort, the average ARR was 0.86% in individuals under the MMT threshold (NNT = 116). The average ARR was 8.19% in individuals above the MMT threshold (NNT = 12). Broad ranges of ADT benefit were observed within National Comprehensive Cancer Network risk categories.

CONCLUSION

The precise and personalized risk estimate of metastasis provided by the CCR score can help inform patients and physicians when considering treatment intensification.
Antipolitics and the Administrative State
Authors: Coglianese Cary , Walters Daniel E.
Published: May 2024

This contribution to the Common Knowledge symposium “Antipolitics” A considers what it might mean for the administrative state to be antipolitical. Two conceptions of an antipolitical administrative state are identified. The first of these—antipolitics as in opposition to administrative discretion—holds that, in a democracy, value judgments should be made only by elected officials and that all administrators should do is carry out technical tasks calling for expertise. Administrators, however, inevitably make policy decisions that call for value judgments, making this first conception unattainable. On the other hand, a second conception or standard—one of antipolitics as in opposition to favoritism—is both realistic and desirable to expect of those who occupy positions of administrative power. It holds that administrators should avoid making decisions for self-interested reasons. Many doctrines of administrative law follow from aversion to favoritism, as the law aspires to free the administrative state from decision-making that is based on the interests of administrators and their partisan overseers or friends. Today, as the state comes under increasing threat from populist and authoritarian attempts to capture its power, distinguishing between these two conceptions of antipolitics—one unrealistic, the other imperative—can help to channel antipolitical impulses where they are most needed.
Endoluminal Biopsy for Vein of Galen Malformation
Authors: Hale Andrew T. , Liu Shanrun , Huang Fengyuan , Song Yuwei , Crowley Michael R. , Crossman David K. , Caudill Caroline , Arynchyna-Smith Anastasia , Chapman Lindsey , Feldman Michael J. , Saccomano Benjamin W. , Rocque Brandon G. , Rozzelle Curtis J. , Blount Jeffrey P. , Johnston James M. , Chong Zechen , Jones Jesse G.
Published: May 2024

BACKGROUND AND OBJECTIVES:

Vein of Galen malformation (VOGM), the result of arteriovenous shunting between choroidal and/or subependymal arteries and the embryologic prosencephalic vein, is among the most severe cerebrovascular disorders of childhood. We hypothesized that in situ analysis of the VOGM lesion using endoluminal tissue sampling (ETS) is feasible and may advance our understanding of VOGM genetics, pathogenesis, and maintenance.

METHODS:

We collected germline DNA (cheek swab) from patients and their families for genetic analysis. In situ VOGM “endothelial” cells (ECs), defined as CD31+ and CD45−, were obtained from coils through ETS during routine endovascular treatment. Autologous peripheral femoral ECs were also collected from the access sheath. Single-cell RNA sequencing of both VOGM and peripheral ECs was performed to demonstrate feasibility to define the transcriptional architecture. Comparison was also made with a published normative cerebrovascular transcriptome atlas. A subset of VOGM ECs was reserved for future DNA sequencing to assess for somatic and second-hit mutations.

RESULTS:

Our cohort contains 6 patients who underwent 10 ETS procedures from arterial and/or venous access during routine VOGM treatment (aged 12 days to ∼6 years). No periprocedural complications attributable to ETS occurred. Six unique coil types were used. ETS captured 98 ± 88 (mean ± SD; range 17-256) experimental ECs (CD31+ and CD45−). There was no discernible correlation between cell yield and coil type or route of access. Single-cell RNA sequencing demonstrated hierarchical clustering and unique cell populations within the VOGM EC compartment compared with peripheral EC controls when annotated using a publicly available cerebrovascular cell atlas.

CONCLUSION:

ETS may supplement investigations aimed at development of a molecular-genetic taxonomic classification scheme for VOGM. Moreover, results may eventually inform the selection of personalized pharmacologic or genetic therapies for VOGM and cerebrovascular disorders more broadly.
Comparison of Postoperative Complications After Gastrectomy for Gastric Cancer with Antecolic Versus Retrocolic Reconstruction: A Population-Based Study
Authors: Junttila Anna , Helminen Olli , Helmiö Mika , Huhta Heikki , Jalkanen Aapo , Kallio Raija , Koivukangas Vesa , Kokkola Arto , Laine Simo , Lietzen Elina , Louhimo Johanna , Meriläinen Sanna , Pohjanen Vesa-Matti , Rantanen Tuomo , Ristimäki Ari , Räsänen Jari V. , Saarnio Juha , Sihvo Eero , Toikkanen Vesa , Tyrväinen Tuula , Valtola Antti , Kauppila Joonas H. ,   on behalf of the FINEGO Group
Published: May 2024

Background

The purpose of this study was to examine the rates of 90-day anastomotic complications and other postoperative complications after total or partial gastrectomy with antecolic versus retrocolic reconstruction in a population-based setting.

Methods

This population-based nationwide retrospective cohort study included all patients undergoing total or partial gastrectomy for gastric adenocarcinoma in Finland in 2005–2016, with follow-up until 31 December 2019. Logistic regression provided odds ratios (ORs) with 95% confidence intervals (CIs) of 90-day mortality. Results were adjusted for age, sex, year of the surgery, comorbidities, tumor locations, pathological stage, and neoadjuvant therapy.

Results

A total of 2063 patients having gastrectomy with antecolic (n = 814) or retrocolic (n = 1249) reconstruction were identified from the registries. The anastomotic complication rate was 3.8% with antecolic reconstruction and 5.0% with retrocolic reconstruction. Antecolic reconstruction was not associated with a higher risk of anastomotic complications compared with retrocolic reconstruction in the adjusted analysis (OR 0.69, 95% CI 0.44–1.09) of the whole cohort or in the predefined subgroups. The reoperation rate was 8.2% with antecolic reconstruction and 7.7% with retrocolic reconstruction, without statistical significance. In subgroup analysis of total gastrectomy patients, the risk of major complications was lower with antecolic reconstruction compared with retrocolic reconstruction (OR 0.62, 95% CI 0.45–0.86).

Conclusions

The rate of anastomotic complications did not differ after antecolic versus retrocolic reconstruction after total or partial gastrectomy. In total gastrectomies, the risk of major complications was lower after antecolic compared with retrocolic reconstruction.
The genome sequence of the Green Pug moth, Pasiphila rectangulata (Linnaeus, 1758)
Authors: Wawman Denise C. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Pasiphila rectangulata (the Green Pug; Arthropoda; Insecta; Lepidoptera; Geometridae). The genome sequence is 582.5 megabases in span. Most of the assembly is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.74 kilobases in length. Gene annotation of this assembly on Ensembl identified 17,153 protein coding genes.
The genome sequence of purple glasswort, Salicornia ramosissima Woods (Amaranthaceae)
Authors: Mian Sahr , Christenhusz Maarten J. M. , Leitch Ilia J. , Leitch Andrew R. ,   Royal Botanic Gardens Kew Genome Acquisition Lab,   Plant Genome Sizing collective,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual Salicornia ramosissima (purple glasswort; Tracheophyta; Magnoliopsida; Caryophyllales; Chenopodiaceae). The genome sequence is 529.1 megabases in span. Most of the assembly is scaffolded into 9 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 328.55 kilobases and 153.3 kilobases in length, respectively.
The genome sequence of the Oak Nycteoline moth, Nycteola revayana (Scopoli, 1772)
Authors: Boyes Douglas , Broad Gavin R. , Holland Peter W. H. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Nycteola revayana (the Oak Nycteoline moth; Arthropoda; Insecta; Lepidoptera; Nolidae). The genome sequence is 621.0 megabases in span. Most of the assembly is scaffolded into 26 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.25 kilobases in length. Gene annotation of this assembly on Ensembl identified 19,235 protein-coding genes.
The genome sequence of an ichneumonid wasp, Amblyjoppa fuscipennis (Wesmael, 1844)
Authors: Mitchell Ryan , Sivell Duncan , Broad Gavin R. ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Amblyjoppa fuscipennis (an ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence is 278.5 megabases in span. Most of the assembly is scaffolded into 10 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 35.62 kilobases in length.
The genome sequence of the Pearl-bordered Fritillary, Boloria euphrosyne (Linnaeus, 1758)
Authors: Martin Simon H. , Lohse Konrad , Ebdon Sam , Mackintosh Alex ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Boloria euphrosyne (the Pearl-bordered Fritillary; Arthropoda; Insecta; Lepidoptera; Nymphalidae). The genome sequence is 400.4 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.17 kilobases in length. Gene annotation of this assembly on Ensembl identified 19,138 protein coding genes.
The genome sequence of the Fig-leaf Skeletoniser, Choreutis nemorana (Hübner, [1799])
Authors: Lees David C. ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Choreutis nemorana (the Fig-leaf Skeletoniser; Arthropoda; Insecta; Lepidoptera; Choreutidae). The genome sequence is 300.2 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.52 kilobases in length. Gene annotation of this assembly on Ensembl identified 15,351 protein coding genes.
The genome sequence of an ichneumonid wasp, Diplazon laetatorius (Fabricius, 1781)
Authors: Broad Gavin R. , Fletcher Chris , Januszczak Inez ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual female Diplazon laetatorius (ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence is 251.0 megabases in span. Most of the assembly is scaffolded into 15 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 29.27 kilobases in length.
The genome sequence of the Lulworth Skipper, Thymelicus acteon (Rottemburg, 1775)
Authors: Lohse Konrad , Vila Roger , Hayward Alex ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Thymelicus acteon (the Lulworth Skipper; Arthropoda; Insecta; Lepidoptera; Hesperiidae). The genome sequence is 537.0 megabases in span. Most of the assembly is scaffolded into 28 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 17.08 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,813 protein-coding genes.
COGNITIVE MODELING OF PROCESSES RELATED TO PERSONNEL MANAGEMENT IN AN ORGANIZATION
Authors: Avetisyan Tatiana V. , Lvovich Ksenia I. , Lvovich Emma M. , Preobrazhensky Yuri P.
Published: May 2024

When managing organizations, it is necessary in many cases to implement personnel management procedures. The paper proposes to use the methodology of cognitive modeling. Then the most effective management decisions and scenarios for the development of events can be selected using the fact that concepts are distinguished that will characterize the current situation in a qualitative and quantitative way. In addition, estimates of the mutual influence of factors are considered. The method of cognitive modeling of the processes of managing the development of the organization's personnel is proposed. In the course of its implementation, cognitive maps are formed. A block diagram aimed at cognitive and simulation dynamic analysis and modeling is presented. The implementation of the development of strategies and forecasts of how the personnel of the organization will develop with the involvement of a cognitive approach is considered in the form of the presented analytical technology. Suggestions for an intelligent advising system are given. The functions that are designed to solve problems related to the development of the company's personnel are shown. In the results, based on the proposed approach, an illustration of the developed scheme of causal relationships in the analysis of violations of technological discipline is given. The results of the work can be useful in modeling and managing the work of personnel in corporate information systems.
Desafíos de Colombia en tiempos del posacuerdo de paz
Authors: Baquero Melo Jairo , Páez Torres Magda
Published: May 2024

La firma del Acuerdo de Paz con las Farc en octubre de 2016 dio comienzo a una diversidad de cambios en muchas regiones del país, con marcados contrastes: varias poblaciones afrontan la presencia de disidencias y de otros actores armados, mientras en algunas zonas se han gestado importantes procesos sociales que involucran a excombatientes y sociedad civil. Así lo recoge el libro ‘El posacuerdo en Colombia’, una iniciativa de la Universidad del Rosario apoyada por la Fundación Fritz Thyssen de Alemania.
Autism and the HCA, 5: co-occurrence of autism and mental health conditions
Authors: Barber Chris
Published: May 2024

This series of articles will explore the neurodivergent condition of autism from a range of different perspectives. This fifth article will explore the co-occurrence of autism and mental health conditions throughout a person's life.
Paramedic role in emergency mental healthcare
Authors: Phillips Joel Simon
Published: May 2024

Background:

Paramedics are increasingly involved in providing emergency mental healthcare through specialist mental health paramedic roles or expanded responsibilities within generalist roles.

Methods:

This article reviews the relevant academic literature to critically evaluate the opportunities and challenges of greater paramedic involvement in mental health.

Findings:

Potential benefits include prompt crisis response, improved service integration, and enhanced accessibility. However, challenges exist around limited mental health training, role ambiguity, care continuity, and stakeholder concerns.

Conclusion:

Realising the benefits of paramedics in mental healthcare requires investment in education, clear protocols, strong governance, and collaboration with mental health professionals and service users to ensure safety and quality.
Peaks and troughs
Authors: Wyatt Dan
Published: May 2024

After experiencing one of the most difficult losses and continuing to navigate the journey of grief, Dan Wyatt reflects on the peaks and troughs of life, the support that is out there during the low points, and the surprisingly therapeutic nature of putting it all down on the page
Equine worming protocols: tackling the increasing problem of anthelmintic resistance
Authors: Mair Tim
Published: May 2024

Anthelmintic resistance is a growing global problem in the equine sector. Only three classes of anthelmintics are authorised for use against equine nematodes, and resistance to all of them has been reported in the UK. Resistance to praziquantel, which is effective against equine tapeworms, has also been reported. The use of anthelmintics therefore needs to be restricted, and adoption of diagnostic-led targeted treatment regimens is essential to protect efficacy and slow further development of resistance. This article discusses current recommendations regarding helminth treatment and control in horses and summarises Controlling ANTiparasitic resistance in Equines Responsibly and British Equine Veterinary Association guidelines published in 2024.
Leaving No One Behind- Teacher Peer Mentoring Before and After the Pandemics: A Mixed-Methods Systematic Review of Spanish and English Literature
Authors: Santos-Rico Juan Evangelista , Bellido-García Roberto Santiago , Rejas-Borjas Luis Gerardo
Published: May 2024

This paper examines how peer mentoring strengthens teaching practices in Regular Basic Education considering the changes undertaken since the COVID-19 pandemics. Peer mentoring is an in-service teacher training strategy that includes mutual collaboration, learning and monitoring. In this systematic review, we retrieved 24 articles since 2020 from Scopus (8), Web of Science (8), Dialnet (5), Google Scholar (2) and SciELO (1) to find out about the benefits of peer mentoring. Our review was guided by the PRISMA criteria. We found that educational companionship has a positive impact on reducing knowledge gaps regarding new technologies through the exchange of experiences, promotes openness to criticism, as well as the interest in learning and unlearning, supporting learning self-regulation, and guarantees consultation, reflection, and agreement between members of the teaching communities. We conclude that peer mentoring fulfilled, to a large extent, its purpose of improving teacher performance as one of the keys to educational quality.