bluuebunny/crossref_metadata_2025 huggingface dataset:
The Computational Complexity of Hierarchical Clustering Algorithms for Community Detection: A Review
Authors: Bui Van Hieu , Phan Huyen Trang
Published: June 2023

Community detection is a highly active research area that aims to identify groups of vertices with similar properties or interests within complex real-world networks. Over the years, a large number of papers have been published, resulting in the development of various community detection algorithms that consider factors such as the type of networks, the nature of communities, and applications. Despite numerous relevant review and survey papers, the literature lacks a comprehensive analysis of the computational complexity of existing community detection algorithms. This review aims to address this gap by providing a more detailed analysis and evaluation of the computational complexity of hierarchical clustering algorithms for community detection, including two main categories: agglomerative and divisive algorithms. We also highlight the main theoretical concepts, emphasizing the benefits and drawbacks of each approach, both in theory and in practical applications. This review helps researchers and practitioners in this field better understand valuable information on the differences and unique features of community detection algorithms with hierarchical community structure.
Electrochemical Detection of Melatonin at Tungsten Oxide Nanospheres Decorated Chitosan Electrode
Authors: Thenrajan Thatchanamoorthy , Girija Srinivasan , Sangeetha Selvaraj , Alwarappan Subbiah , Wilson Jeyaraj
Published: June 2023

Melatonin is a clinically important hormone as it plays a key role in maintaining immune system, circadian rhythm, blood pressure and cortisol levels. Therefore, its real time detection is crucial for monitoring body function. Melatonin detection by electrochemical sensors exhibits advantages such as high sensitivity, point-of-care analysis, rapid response time, easy to use and cost-effective. Natural polymer based biocomposites including chitosan, gum acacia, xanthan gum, chitin are widely employed due to their ready availability, low cost, biocompatibility and high surface area for biosensing applications. Herein, we investigated tungsten oxide (WO3) nanospheres decorated with functionalized chitosan (FCH) for melatonin detection. The functionalization of chitosan introduced plentiful amine groups and inter-hydrogen bonding that are essential for the formation of WO3/FCH biocomposite. Further, the large density of amine groups offered efficient binding affinity with WO3 and improved the conductivity of the nanocomposite thereby enabling sensitive melatonin detection. Electroanalysis confirmed the excellent electrocatalytic performance of the biocomposite towards melatonin with a limit of detection of 4.9 nM. The proposed nanocomposite exhibited excellent selectivity, reproducibility, stability. Further, its practical reliability was evaluated in real samples thereby demonstrating its usefulness in the detection of clinically relevant biomolecules.
Virtual reality: a technology to promote active learning of physiology for students across multiple disciplines
Authors: Ma Chun-Wai , Cheng Pui-Sum , Chan Ying-Shing , Tipoe George Lim
Published: June 2023

Virtual reality (VR) improves physiology education by promoting active learning in terms of interactive engagement, interest, problem-solving skills, and feedback. Positive responses toward multiple components of active learning were received from students across different disciplines. The majority of students agreed that VR learning of physiology not only stimulated their curiosity but also allowed them to obtain knowledge through diverse formats, participate in thought-provoking dialogue, and interact better with peers.
Sagittal kinematics and imbalance of the spine and whole body during walking in late-onset Pompe disease
Authors: De Blasiis Paolo , Fullin Allegra , Mazzoli Davide , Bruno Giorgia , Napolitano Filomena , De Luca Antonio , Melone Mariarosa Anna Beatrice , Sampaolo Simone
Published: June 2023

This study is the first to quantitatively characterize the sagittal spine and whole body posture of patients with late-onset Pompe disease during walking, showing a pathological kinematic pattern defined “man falling backwards.” 3-D-motion analysis, with a specific marker set (DB-total protocol) introducing new whole body kinematic parameters, may be useful for accurate functional evaluation and monitoring this rare disease.
Design and Fabrication of Metallic-Conductive Polymer-Based Hybrid Film Interconnections for Stretchable Electronic Devices
Authors: Sucharitha M. , Thomas Reena , Jyothi B. , Onyema Edeh Michael , Bekele Gashaw
Published: June 2023

Stretchable circuit is a technological innovation that has transformed the microelectronic landscape due to its enormous applications in the field of medicine. The consistency or durability of health monitoring devices can increase the dependability with which non-invasive clinical measures are collected. Metal–conductive polymer (CP) hybrid interconnects and metal–polyimide dual-layered interconnects were all produced as stretchable interconnections. Stretchable substrate for all of the interconnects was selected as soft elastomer polydimethylsiloxane (PDMS). However, the PDMS substrate presents challenges because it is temperature sensitive, limiting the process temperature. The extreme hydrophobic nature of the PDMS surface makes it difficult to deposit components that contain water and results in poor adhesion with different metals. Following the development of processes for fabricating materials on the PDMS substrate, methods for resolving these issues were investigated.
A Management Specification for Data Sharing Security in the System Construction of Smart Mine
Authors: Wang Haitao , Tan Lina , Zhang Yang , Gong Qiwen , Zhang Shan , Ren Yanan , He Tao
Published: June 2023

With the development of Internet of Things technology and the informatization of the coal industry, various intelligent applications have emerged in the process of the system construction of the smart mine. During this process, data sharing is essential to the effective use of data resources in the smart mine. In order to improve the protection of coal mine data, this study proposes a set of management specifications for data sharing applied to the system construction of a smart mine to unify security standards in data storage and sharing. It standardizes the processes of data collection, transmission, and storage. We design three subspecifications for these processes, namely, data source specification, data quality specification, and data storage specification. The data source specification specifies the data collection and transmission standards to improve the security and timeliness of data sharing. The data quality specification sets three evaluation criteria of integrity, accuracy, and timeliness according to the characteristics of each business system and data. The system ensures data quality during data sharing by governing and recording the data failing to meet the criteria. The data storage specification specifies the data storage protocol, data label, and data set restrictions. Only authorized platforms and users can share data and make use of data labels to search data efficiently. Finally, we constructed a coal mine data collection and analysis system. It can collect, manage, store, and safely share the real measured data from a certain colliery according to the specifications.
Hybrid Prosthesis versus Overdenture: Effect of BioHPP Prosthetic Design Rehabilitating Edentulous Mandible
Authors: Al-Asad Hanan Mohsen , El Afandy Mahmoud Hassan , Mohamed Hebatallah Tarek , Mohamed Magda Hassan
Published: June 2023

Aim. To compare the BioHPP (biocompatible high-performance polymer) as a substructure for the hybrid prosthesis versus the BioHPP bar supporting and retaining implant overdenture by radiographic evaluation to identify bone height alteration around the implants and to evaluate satisfaction based on visual analoge scale questionnaire. Materials and Methods. Ill-fitting mandibular dentures were chosen for 14 fully edentulous male patients with adequate dental hygiene, enough interarch space, and free of systemic diseases and parafunctional habits. Patients who received new dentures (CDs) were randomly allocated into each group using computer software, and four interforaminal implants were inserted in parallel using a surgical guide. Three months after osseointegration, the patients received either CAD–CAM BioHPP framework hybrid prosthesis (Group I) or BioHPP bar supported and retained overdenture (Group II). Using digital preapical radiography, the bone loss is evaluated 6, 12, and 18 months after insertion. The subjective patient evaluation was done using a questionnaire based on the VAS includes five points for chewing, comfort, esthetics, speech, oral hygiene, and general satisfaction. Results. The overall marginal bone loss (MBL) revealed that Group I (hybrid prosthesis) was more than Group II (bar overdenture) at all intervals in the anterior and posterior implants’ mesial and distal surfaces. The patient satisfaction survey results showed that, after 18 months, the difference was statistically not significant between them all (

P
>
0.05

) except for the comfort (for the overdenture group, 4.43 ± 0.53 while the fixed hybrid was 5.00 ± 0.00). Conclusion. BioHPP framework material is an alternative material for implant rehabilitation of edentulous mandible with minimal MBL in BioHPP bar overdenture compared to BioHPP hybrid prosthesis.
Enteral Nutrition Safety and Outcomes of Patients with COVID-19 on Continuous Infusion of Neuromuscular Blockers: A Retrospective Study
Authors: Al-Dorzi Hasan M. , Yaqoub Reem , Alalmaee Reema , Almutairi Ghafran , Almousa Allulu , Aldawsari Leen
Published: June 2023

Background. Intravenous infusions of neuromuscular blocking agents (NMBAs) and prone positioning are recommended for acute respiratory distress syndrome (ARDS) due to COVID-19. The safety of enteral nutrition (EN) during these treatments is unclear. This study assessed EN tolerance and safety during NMBA infusion in proned and nonproned patients with ARDS due to COVID-19. Methods. This retrospective study evaluated patients who were admitted to a tertiary-care ICU between March and December 2020, had ARDS due to COVID-19, and received NMBA infusion. We assessed their EN data, gastrointestinal events, and clinical outcomes. The primary outcome was gastrointestinal intolerance, defined as a gastric residual volume (GRV) ≥500 ml or 200–500 ml with vomiting. We compared proned and nonproned patients. Results. We studied 181 patients (mean age 61.2 ± 13.7 years, males 71.1%, and median body mass index 31.4 kg/m2). Most (63.5%) patients were proned, and 94.3% received EN in the first 48 hours of NMBA infusion at a median dose <10 kcal/kg/day. GRV was mostly below 100 ml. Gastrointestinal intolerance occurred in 6.1% of patients during NMBA infusion and 10.5% after NMBA discontinuation (similar rates in proned and nonproned patients). Patients who had gastrointestinal intolerance during NMBA infusion had a higher hospital mortality (90.9% versus 60.0%;

p
=
0.05

) and longer mechanical ventilation duration and ICU and hospital stays compared with those who did not. Conclusion. In COVID-19 patients on NMBA infusion for ARDS, EN was provided early at low doses for most patients, and gastrointestinal intolerance was uncommon in proned and nonproned patients, occurred at a higher rate after discontinuing NMBAs and was associated with worse outcomes. Our study suggests that EN was tolerated and safe in this patient population.
Supplementary Figures from Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation
Authors: Savage Hannah , Pareek Sumedha , Lee Jonghae , Ballarò Riccardo , Conterno Minussi Darlan , Hayek Karma , Sadullozoda Mumina , Lochmann Brooke S. , McQuade Jennifer L. , LaVoy Emily C. , Marmonti Enrica , Patel Hetal , Wang Guangyu , Imanishi Masaki , Kotla Sivareddy , Abe Jun-ichi , Schadler Keri
Published: June 2023

Supplementary Figures S1-S8
Data from Aerobic exercise alters the melanoma microenvironment and modulates ERK5 S496 phosphorylation
Authors: Savage Hannah , Pareek Sumedha , Lee Jonghae , Ballarò Riccardo , Conterno Minussi Darlan , Hayek Karma , Sadullozoda Mumina , Lochmann Brooke S. , McQuade Jennifer L. , LaVoy Emily C. , Marmonti Enrica , Patel Hetal , Wang Guangyu , Imanishi Masaki , Kotla Sivareddy , Abe Jun-ichi , Schadler Keri L.
Published: June 2023

Abstract
Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration by cytotoxic immune cells. The mechanisms driving these changes remain unclear. Herein, we demonstrate that exercise normalizes tumor vasculature and upregulates endothelial expression of VCAM1 in YUMMER 1.7 and B16F10 murine models of melanoma but differentially regulates tumor growth, hypoxia, and the immune response. We found that exercise suppressed tumor growth and increased CD8+ T-cell infiltration in YUMMER but not in B16F10 tumors. Single-cell RNA sequencing and flow cytometry revealed exercise modulated the number and phenotype of tumor-infiltrating CD8+ T cells and myeloid cells. Specifically, exercise caused a phenotypic shift in the tumor-associated macrophage population and increased the expression of major histocompatibility complex class II transcripts. We further demonstrated that ERK5 S496A knock-in mice, which are phosphorylation deficient at the S496 residue, ‘mimicked’ the exercise effect when unexercised, yet when exercised, these mice displayed a reversal in the effect of exercise on tumor growth and macrophage polarization compared to wild-type mice. Taken together, our results reveal tumor-specific differences in the immune response to exercise and show that ERK5 signaling via the S496 residue plays a crucial role in exercise-induced tumor microenvironment changes.  
Data from Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation
Authors: Savage Hannah , Pareek Sumedha , Lee Jonghae , Ballarò Riccardo , Conterno Minussi Darlan , Hayek Karma , Sadullozoda Mumina , Lochmann Brooke S. , McQuade Jennifer L. , LaVoy Emily C. , Marmonti Enrica , Patel Hetal , Wang Guangyu , Imanishi Masaki , Kotla Sivareddy , Abe Jun-ichi , Schadler Keri
Published: June 2023

Abstract
Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration by cytotoxic immune cells. The mechanisms driving these changes remain unclear. Herein, we demonstrate that exercise normalizes tumor vasculature and upregulates endothelial expression of VCAM1 in YUMMER 1.7 and B16F10 murine models of melanoma but differentially regulates tumor growth, hypoxia, and the immune response. We found that exercise suppressed tumor growth and increased CD8+ T-cell infiltration in YUMMER but not in B16F10 tumors. Single-cell RNA sequencing and flow cytometry revealed exercise modulated the number and phenotype of tumor-infiltrating CD8+ T cells and myeloid cells. Specifically, exercise caused a phenotypic shift in the tumor-associated macrophage population and increased the expression of MHC class II transcripts. We further demonstrated that ERK5 S496A knock-in mice, which are phosphorylation deficient at the S496 residue, “mimicked” the exercise effect when unexercised, yet when exercised, these mice displayed a reversal in the effect of exercise on tumor growth and macrophage polarization compared with wild-type mice. Taken together, our results reveal tumor-specific differences in the immune response to exercise and show that ERK5 signaling via the S496 residue plays a crucial role in exercise-induced tumor microenvironment changes.
TABLE 1 from Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics
Authors: Kazmierski Michal , Welch Mattea , Kim Sejin , McIntosh Chris , Rey-McIntyre Katrina , Huang Shao Hui , Patel Tirth , Tadic Tony , Milosevic Michael , Liu Fei-Fei , Ryczkowski Adam , Kazmierska Joanna , Ye Zezhong , Plana Deborah , Aerts Hugo J.W.L. , Kann Benjamin H. , Bratman Scott V. , Hope Andrew J. , Haibe-Kains Benjamin
Published: June 2023

Summary of challenge submissions and performance metrics. All models achieved performance better than random (FDR < 5%)
Supplementary Figure S4 from Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics
Authors: Kazmierski Michal , Welch Mattea , Kim Sejin , McIntosh Chris , Rey-McIntyre Katrina , Huang Shao Hui , Patel Tirth , Tadic Tony , Milosevic Michael , Liu Fei-Fei , Ryczkowski Adam , Kazmierska Joanna , Ye Zezhong , Plana Deborah , Aerts Hugo J.W.L. , Kann Benjamin H. , Bratman Scott V. , Hope Andrew J. , Haibe-Kains Benjamin
Published: June 2023

Model performances across permutations by clinical and imaging variables.
Supplementary Figure S1 from Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics
Authors: Kazmierski Michal , Welch Mattea , Kim Sejin , McIntosh Chris , Rey-McIntyre Katrina , Huang Shao Hui , Patel Tirth , Tadic Tony , Milosevic Michael , Liu Fei-Fei , Ryczkowski Adam , Kazmierska Joanna , Ye Zezhong , Plana Deborah , Aerts Hugo J.W.L. , Kann Benjamin H. , Bratman Scott V. , Hope Andrew J. , Haibe-Kains Benjamin
Published: June 2023

Patient selection and data curation process.
FIGURE 3 from Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics
Authors: Kazmierski Michal , Welch Mattea , Kim Sejin , McIntosh Chris , Rey-McIntyre Katrina , Huang Shao Hui , Patel Tirth , Tadic Tony , Milosevic Michael , Liu Fei-Fei , Ryczkowski Adam , Kazmierska Joanna , Ye Zezhong , Plana Deborah , Aerts Hugo J.W.L. , Kann Benjamin H. , Bratman Scott V. , Hope Andrew J. , Haibe-Kains Benjamin
Published: June 2023

Volume dependence of predictions. Spearman rank correlation of the predictions of each model with tumor volume against performance in terms of AUROC (A) and C-index (B), respectively. The top models fall into an optimal region of low (but nonzero) volume correlation and high performance. Note that while models 1 and 2 used tumor volume as one of the input variables, their predictions correlate with volume only moderately (ρ < 0.5), indicating they are able to exploit additional information present in the EMR features. Higher correlation leads to decreased performance as the predictions are increasingly driven by volume only. Most radiomics-only models fall in the high correlation region (ρ ≥ 0.5), although deep learning predictions correlate at notably lower level than engineered features. Interestingly, the best radiomics submission (number 9) achieves the lowest volume correlation, suggesting that it might be using volume-independent imaging characteristics.
Data from A Th1-like CD4+ T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Authors: Yanagihara Akitoshi , Yamasaki Satoshi , Hashimoto Kosuke , Taguchi Ryo , Umesaki Tetsuya , Imai Hisao , Kaira Kyoichi , Nitanda Hiroyuki , Sakaguchi Hirozo , Ishida Hironori , Kobayashi Kunihiko , Horimoto Katsuhisa , Kagamu Hiroshi
Published: June 2023

Perioperative immune checkpoint inhibitors have been shown to improve prognosis in early-stage lung cancer. However, no biomarkers are known to indicate the requirement for treatment. This study aimed to identify T-cell clusters responsible for antitumor immunity in patients with early-stage lung cancer. Preoperative blood samples from 50 consecutive patients with lung cancer who were diagnosed as operable and underwent complete resection were analyzed by mass cytometry. Patients were divided into two groups: no recurrence at a minimum observation period of 851 days (median observation period: 1,031.5 days) and recurrence by the last observation date. Mass cytometry and single-cell RNA sequencing analysis of lymph nodes (LN) and tumor-infiltrating T cells were also performed. CCR4−CCR6+ Th7R showed discriminative ability between recurrence and non-recurrence patients with lung cancer. Patients with more than 3.04% Th7R showed significantly favorable disease-free survival. Th7R was a major component of CD4+ T cells in tumor microenvironments and LNs adjacent to lung cancer tissues and was the only cluster that decreased in peripheral blood after the removal of cancer tissues, suggesting that Th7R was primed and proliferated in tumor-draining LNs in the presence of cancer tissues. Th7R had the kinetics that antitumor T cells should have, as indicated by the cancer immunity cycle; thus, peripheral blood Th7R could represent the potency of tumor immunity by reflecting priming and proliferation in tumor-draining LNs and Th7R in the tumor microenvironment. Prediction using peripheral Th7R before surgery could allow the selection of patients who require perioperative drug therapy and optimize therapeutic interventions with clinical implications.
Significance:
Peripheral Th7R, a Th1-like CD4+ T-cell cluster reflecting priming status in draining LNs and immune status in the tumor microenvironment, predicts disease-free survival after complete resection and has significant clinical relevance in selecting appropriate therapeutic interventions in patients with early-stage lung cancer.
Data from A Th1-like CD4+ T-cell Cluster that Predicts Disease-free Survival in Early-Stage Lung Cancer
Authors: Yanagihara Akitoshi , Yamasaki Satoshi , Hashimoto Kosuke , Taguchi Ryo , Umesaki Tetsuya , Imai Hisao , Kaira Kyoichi , Nitanda Hiroyuki , Sakaguchi Hirozo , Ishida Hironori , Kobayashi Kunihiko , Horimoto Katsuhisa , Kagamu Hiroshi
Published: June 2023

Abstract
Perioperative immune checkpoint inhibitors have been shown to improve prognosis in early-stage lung cancer. However, no biomarkers are known to indicate the requirement for treatment. This study aimed to identify T-cell clusters responsible for antitumor immunity in early-stage lung cancer patients. Preoperative blood samples from 50 consecutive lung cancer patients who were diagnosed as operable and underwent complete resection were analyzed by mass cytometry. Patients were divided into two groups: no recurrence at a minimum observation period of 851 days (median observation period: 1,031.5 days) and recurrence by the last observation date. Mass cytometry and single-cell RNA sequencing analysis of lymph nodes (LNs) and tumor-infiltrating T cells were also performed. CCR4-CCR6+ Th7R showed discriminative ability between recurrence and non-recurrence lung cancer patients. Patients with more than 3.04% Th7R showed significantly favorable disease-free survival. Th7R was a major component of CD4+ T cells in tumor microenvironments and LNs adjacent to lung cancer tissues and was the only cluster that decreased in peripheral blood after the removal of cancer tissues, suggesting that Th7R was primed and proliferated in tumor-draining LNs in the presence of cancer tissues. Th7R had the kinetics that antitumor T cells should have, as indicated by the cancer immunity cycle; thus, peripheral blood Th7R could represent the potency of tumor immunity by reflecting priming and proliferation in tumor-draining LNs and Th7R in the tumor microenvironment. Prediction using peripheral Th7R before surgery could allow the selection of patients who require perioperative drug therapy and optimize therapeutic interventions with clinical implications.
A Th1-like CD4+ T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Authors: Yanagihara Akitoshi , Yamasaki Satoshi , Hashimoto Kosuke , Taguchi Ryo , Umesaki Tetsuya , Imai Hisao , Kaira Kyoichi , Nitanda Hiroyuki , Sakaguchi Hirozo , Ishida Hironori , Kobayashi Kunihiko , Horimoto Katsuhisa , Kagamu Hiroshi
Published: June 2023

Perioperative immune checkpoint inhibitors have been shown to improve prognosis in early-stage lung cancer. However, no biomarkers are known to indicate the requirement for treatment. This study aimed to identify T-cell clusters responsible for antitumor immunity in patients with early-stage lung cancer. Preoperative blood samples from 50 consecutive patients with lung cancer who were diagnosed as operable and underwent complete resection were analyzed by mass cytometry. Patients were divided into two groups: no recurrence at a minimum observation period of 851 days (median observation period: 1,031.5 days) and recurrence by the last observation date. Mass cytometry and single-cell RNA sequencing analysis of lymph nodes (LN) and tumor-infiltrating T cells were also performed. CCR4−CCR6+ Th7R showed discriminative ability between recurrence and non-recurrence patients with lung cancer. Patients with more than 3.04% Th7R showed significantly favorable disease-free survival. Th7R was a major component of CD4+ T cells in tumor microenvironments and LNs adjacent to lung cancer tissues and was the only cluster that decreased in peripheral blood after the removal of cancer tissues, suggesting that Th7R was primed and proliferated in tumor-draining LNs in the presence of cancer tissues. Th7R had the kinetics that antitumor T cells should have, as indicated by the cancer immunity cycle; thus, peripheral blood Th7R could represent the potency of tumor immunity by reflecting priming and proliferation in tumor-draining LNs and Th7R in the tumor microenvironment. Prediction using peripheral Th7R before surgery could allow the selection of patients who require perioperative drug therapy and optimize therapeutic interventions with clinical implications.

Significance:

Peripheral Th7R, a Th1-like CD4+ T-cell cluster reflecting priming status in draining LNs and immune status in the tumor microenvironment, predicts disease-free survival after complete resection and has significant clinical relevance in selecting appropriate therapeutic interventions in patients with early-stage lung cancer.
O uso de agentes psicodélicos no tratamento da dependência de álcool e tabaco: revisão integrativa
Authors: Borges Eduarda Medrado Araújo , Barbosa Junior Glauber Carvalho , Araújo Alyce Maryana Costa , Moraes Marianna Nunes de , Nunes Jonatha Rospide
Published: June 2023

Objetivo: analisar os estudos que abordam o o uso deagentes psicodélicos no tratamento da dependência de álcoole tabaco no contexto nacional e internacional. Método:revisão integrativa na Literatura Latino-Americana e do Caribeem Ciências da Saúde (LILACS), Medical Literature Analysisand Retrievel System Online (Medline), Scientific EletronicLibrary Online (SciELO), EBSCO e PubMed, utilizando-seos descritores: “Alucinógenos”, “Dependência Química”,“Tratamento”, “Alcoolismo”, “Tabagismo”, “Hallucinogens”,“Chemical Dependence”, “Treatment”, “Alcoholism”, “TobaccoUse Disorder”. Resultados: a amostra final totalizou 14artigos, que abordaram o uso de agentes psicodélicos notratamento de dependência de álcool e tabaco, no contextonacional e internacional. Conclusão: o uso de agentespsicodélicos no tratamento da dependência de álcool e tabaco,não é conclusivo no tratamento da dependência química comoterapêutica única, entretanto, sua utilização pode ser umainovação eficaz para os modelos atuais de tratamentos, demodo que engloba a experiência psicodélica do paciente e arelação desta com o tratamento.
Os benefícios do exercício físico na saúde mental e no declínio cognitivo do idoso: uma revisão integrativa
Authors: Silva Joanair Rodrigues da , Lima Lorena Maria Ferreira de , Felício Janiel Ferreira , Sousa Albertina Antonielly Sydney de , Brasil Eysler Gonçalves Maia , Amaral Jeferson Falcão do
Published: June 2023

Objetivo: analisar a produção científica acerca dos efeitospositivos do exercício físico na saúde mental e no declíniocognitivo do idoso. Metodologia: trata-se de uma revisãointegrativa da literatura, realizada em 2021, cuja perguntanorteadora foi: Quais são os benefícios do exercício físico nasaúde mental dos idosos? A busca das produções foi realizadanas bases de dados Scientific Electronic Library Online, Webof Science e National Library of Medicine/National Institutesof Health, por meio da utilização dos descritores controlados“aged”, “physical exercise”, “mental health” e “disfunçãocognitiva”. Os artigos foram analisados por 2 pesquisadorese, após extração dos resultados, outro pesquisador realizou arevisão dos dados. Resultados: após aplicação dos critériosde inclusão e exclusão, bem como leitura de título e resumo eposterior leitura completa dos estudos, restaram 19 produçõescujo nível de evidência foi analisado. Os resultados revelaramos seguintes benefícios relacionados à prática de exercíciosfísicos: melhores pontuações no Mini Exame do Estado Mental(MEEM); melhor autopercepção da saúde mental; prevençãodo declínio cognitivo e retardo em sua progressão; diminuiçãodos sinais e sintomas depressivos e desenvolvimento derelações sociais efetivas e duradouras. Conclusão: os artigosanalisados mostraram que a prática de exercícios físicos pelosidosos pode auxiliar no controle dos prejuízos cognitivos e nosurgimento de problemas de saúde mental, e proporcionaro desenvolvimento de relações sociais efetivas e duradoras,fatores relacionados à melhor qualidade de vida e bem-estar.
Assistência a pessoas com autolesão não suicida: construção e validação de um cenário simulado
Authors: Ramos Aline Mendonça , Silva Aline Conceição , Pedrollo Laysa Fernanda Silva , Vedana Kelly Graziani Giacchero
Published: June 2023

Objetivo: construir e validar um cenário simulado paraassistência à saúde de pessoas com autolesão não suicida.Metodologia: estudo metodológico de construção evalidação de um cenário simulado de alta fidelidade.A construção do cenário foi baseada em um roteiro de boaspráticas em simulação de alta fidelidade e autolesão nãosuicida. A validação foi realizada com onze especialistas.A validação do cenário simulado foi realizada com usoda escala Likert de três pontos (Bom, Regular e Ruim).Os dados obtidos foram analisados por meio de umsoftware estatístico através de análise descritiva, Índicede Validade de Conteúdo e teste de Gwet. Resultados: ocenário obteve concordância geral de 97% entre os juízesespecialistas e todos os itens individuais apresentaramÍndice de Validade de Conteúdo acima de 0,80. O cenárioobteve alta confiabilidade total (teste de Gwet: 0,9438) econfiabilidade em ambos os tópicos de interesse no testede Gwet. Conclusão: o cenário simulado de autolesão nãosuicida desenvolvido tem potencial para contribuir com aformação de recursos humanos em saúde para atendimentode pessoas com autolesão não suicida.
Esquemas iniciais desadaptativos e modos esquemáticos em mulheres dependentes químicas com Transtorno de Personalidade Borderline
Authors: Sberse Larissa Biessek , Ávila Andressa Celente de , Carvalho Carolina Del Pino , Rospide Eduarda Baldissera , Alexandre Bárbara Stein , Oliveira Margareth da Silva
Published: June 2023

Objetivo: a Terapia do Esquema é uma abordagem integrativae estruturada desenvolvida inicialmente para o tratamento detranstornos de personalidade em pacientes crônicos. O presenteestudo teve como objetivo principal averiguar as associaçõesde Esquemas Iniciais Desadaptativos e Modos Esquemáticosem mulheres, dependentes químicas, com o transtorno depersonalidade Borderline em comorbidade. Metodologia:trata-se de uma pesquisa com delineamento transversal,quantitativo e descritivo. Foram utilizados os seguintesinstrumentos de avaliação: ficha de dados sociodemográficos;entrevista clínica estruturada para os transtornos do ManualEstatístico de Transtornos Mentais – IV e V; Young SchemaQuestionnaire; e o Schema Mode Inventory. A amostra geralcaracterizou-se por 35 mulheres, com idades entre 18 e 62anos, que deram origem a um subgrupo de 17 participantes quepreencheram os critérios para o Transtorno de PersonalidadeBorderline, de acordo com o DSM V. Resultados: na associaçãodos Esquemas Iniciais Desadaptativos, foram encontrados,uma significância p’ 0,190 em Abandono, uma significânciap’ 0,042 em Defectividade/Vergonha e uma significânciap’ 0,037 em Dependência/Incompetência, o que mostra queas médias, apresentaram diferença significativa. Conclusão:em relação às associações entre os Modos Esquemáticos, nãohouve diferença significativa entre os grupos.
Clinical and Microbiologic Outcomes of Ceramic Laminate Veneers Bonded to Teeth Without a Finish Line: 1-year Results of a Prospective Study
Authors: de Oliveira Danila , Souza Fernando , Caixeta Mariana , Duque Cristiane , Oliveira Sandra , Rocha Eduardo
Published: June 2023

Purpose: To evaluate changes in the periodontium of teeth restored with ultrathin (0.2 to 0.39 mm) ceramic laminate veneers (CLVs) placed subgingivally without a finish line compared to the same teeth before restorative treatment and to nonrestored antagonist teeth in healthy periodontium patients. Materials and Methods: A total of 73 CLVs were bonded onto the enamel surface of teeth without a finish line and with the cervical margin placed about 0.5 mm subgingivally. The gingival crevicular fluid was collected before bonding (baseline) and at 7, 180, and 365 days after bonding to quantify S mitis, P intermedia, and P gingivalis by quantitative polymerase chain reaction analysis. Visible plaque index (VPI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), gingival recession (GR), and marginal adaptation were evaluated from baseline to 365 days in both groups. Results: No statistically significant differences were observed in VPI, PD, or BOP at any time point in the intragroup or intergroup comparisons (P > .05). All restorations obtained the alpha concept for marginal adaptation (ie, the restoration margin remained ideal at all time points). There was a statistically significant difference for S mitis between 180 and 365 days (P = .03). No statistically significant difference was observed for P gingivalis at any time point (P > .05). Conclusion: The periodontium in the restored group showed a clinical behavior similar to baseline. Overcontouring of the ultrathin (up to 0.39 mm) CLV, similar to the cementoenamel junction convexity, did not contribute to plaque accumulation or changes in the oral microbiota of patients with a healthy periodontium and proper oral hygiene instruction.
Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling
Authors: van Ommen Anne-Mar , Diez Benavente Ernest , Onland-Moret N. Charlotte , Valstar Gideon B. , Cramer Maarten J. , Rutten Frans H. , Teske Arco J. , Menken Roxana , Hofstra Leonard , Tulevski Igor I. , Sweitzer Nancy , Somsen G. Aernout , den Ruijter Hester M.
Published: June 2023

BACKGROUND:

Concentric remodeling (cRM) can precede heart failure with preserved ejection fraction (HFpEF), a condition prevalent in women.

METHODS:

Patients (n=60 593, 54.2% women) visiting outpatient clinics of Cardiology Centers of the Netherlands were analyzed for cRM, HFpEF development, and mortality risk. We studied risk factors for relative wall thickness both sex-stratified and in women and men combined. Biomarker profiling was performed (4534 plasma proteins) in a substudy involving 557 patients (65.4% women) to identify pathways involved in cRM.

RESULTS:

cRM was present in 23.5% of women and 27.6% of men and associated with developing HFpEF (HR, 2.15 [95% CI, 1.51–2.99]) and mortality risk (HR, 1.09 [95% CI, 1.00–1.19]) in both sexes. Age, heart rate, and hypertension were statistically significantly stronger risk factors for relative wall thickness in women than men. Higher circulating levels of IFNA5 (interferon alpha-5) were associated with higher relative wall thickness in women only. Pathway analysis revealed differential pathway activation by sex and increased expression of inflammatory pathways in women.

CONCLUSIONS:

cRM is prevalent in approximately 1 in 4 women and men visiting outpatient cardiology clinics and associated with HFpEF development and mortality risk in both sexes. Known risk factors for cRM were more strongly associated in women than men. Proteomic analysis revealed inflammatory pathway activation in women, with a central role for IFNA5. Differential biologic pathway activation by sex in cRM may contribute to the female predominance of HFpEF and holds promise for identification of new therapeutic avenues for prevention and treatment of HFpEF.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT001747.
Impact of Neighborhood Social Deprivation on Health Care Costs Associated With TAVR
Authors: Sidhu Hasrit , Qiu Feng , Manoragavan Ragavie , Ko Dennis T. , Mamas Mamas A , Sud Maneesh , Tam Derrick Y. , Wijeysundera Harindra C.
Published: June 2023

BACKGROUND:

Cumulative costs of transcatheter aortic valve replacement (TAVR) differ in the referral, procedural and postprocedural phases depending on patient comorbidities, type of procedure, and procedural complications. Our goal was to determine the association between neighborhood measures of social deprivation and TAVR costs in each of the 3 phases.

METHODS:

Demographics, patient comorbidities, procedural details, in-hospital complications, and costs for adults undergoing TAVR between 2017 and 2020 in Ontario, Canada were obtained from administrative databases and linked to social deprivation data using the Ontario Marginalization Index. The 3 dimensions of social deprivation assessed were (1) material deprivation, (2) residential instability, and (3) ethnic concentration. Hierarchical generalized linear models were used to determine the association between neighborhood social deprivation and cumulative TAVR costs, reported in 2018 Canadian dollars.

RESULTS:

We identified a total of 7617 TAVR referrals with 3784 patients undergoing TAVR within our study period. Cumulative mean costs in the referral, procedural and postprocedural phases were $8116±$11 374, $32 790±$17 766, and $18 901±$32 490, respectively. After adjustment for clinical and demographic variables, higher factor scores in residential instability were associated with greater cumulative costs in the postprocedural phase, whereas higher factor scores in the other 2 dimensions of marginalization were not significantly associated with higher costs in any of the 3 phases.

CONCLUSIONS:

This analysis shows that residential instability is associated with higher cumulative costs in the postprocedural phase of TAVR. This lays the foundation for future studies to understand the mechanism of this finding and identify potential mitigation policies.
Six new species of fossil soldier beetles (Coleoptera: Cantharidae) from Eocene Baltic amber
Authors: PANKOWSKI MAXIMILIAN G. , Fanti FABRIZIO FANTI
Published: June 2023

We describe and illustrate six new species of the family Cantharidae from Baltic amber: Sucinorhagonycha maryae sp. nov. (Cantharinae, Cacomorphocerini), Podistra madelineae sp. nov. (Cantharinae, Cantharini), Malthinus (Malthinus) karenpankowskiae sp. nov. (Malthininae, Malthinini), Malthinus (Malthinus) pauljohnsoni sp. nov. (Malthininae, Malthinini), Malthodes (Libertimalthodes) betseyae sp. nov. (Malthininae, Malthodini) and Malthodes (Malthodes) greenwalti sp. nov. (Malthininae, Malthodini). These new taxa add to the astonishing palaeodiversity documented in Baltic amber, demonstrating the wide range of organisms thriving in European forests and wooded areas during the Eocene. Extant species of Malthodes, Malthinus and Podistra also provide important clues to how these extinct taxa lived, fed and reproduced some 35–40 million years ago.
New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. XX. Evseevite, Na2Mg(AsO4)F, the first natural arsenate with an antiperovskite structure
Authors: Pekov Igor V. , Zubkova Natalia V. , Agakhanov Atali A. , Vigasina Marina F. , Yapaskurt Vasiliy O. , Britvin Sergey N. , Turchkova Anna G. , Sidorov Evgeny G. , Zhitova Elena S. , Pushcharovsky Dmitry Yu.
Published: June 2023

The new mineral evseevite was found in the Arsenatnaya fumarole, Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. Evseevite is represented by two chemical varieties. The variety close to the end-member Na2Mg(AsO4)F (holotype) is associated with sanidine, hematite, tenorite, aegirine, cassiterite, sylvite, halite, johillerite, badalovite, calciojohillerite, hatertite, arsmirandite, yurmarinite, axelite, polyarsite, aphthitalite, potassic-magnesio-fluoro-arfvedsonite, litidionite, ferrisanidine and tridymite. The P- and S-enriched variety (cotype) is associated with hematite, fluorophlogopite, svabite, fluorapatite, tilasite, calciojohillerite, forsterite, cassiterite, belomarinaite and aphthitalite. Evseevite occurs as prismatic, acicular or hair-like crystals up to 0.7 mm long combined in clusters up to 0.5 mm, brushes or crusts up to 2 × 2 mm. It is transparent, colourless or pale pinkish, with vitreous lustre. Dcalc is 3.377 g cm–3 for the holotype and 3.226 g cm–3 for the cotype. Evseevite is optically uniaxial (+), α = 1.545(2), β = 1.546(2), γ = 1.549(2) and 2Vmeas = 40(10)°. The empirical formulae calculated based on O+F = 5 apfu are (Na1.99Ca0.03K0.01)Σ2.03(Mg0.98Fe3+0.01Zn0.01Cu0.01)Σ1.01[(As0.98Si0.01)Σ1.01O4](F0.97O0.03) for the holotype and Na2.02(Mg1.00Fe3+0.03)Σ1.03[(As0.69P0.25S0.07)Σ1.01O4](F0.78O0.22) for the cotype. Evseevite is orthorhombic, Pbcn, a = 5.3224(1), b = 14.1255(3), c = 12.0047(3) Å, V = 902.53(4) Å3 and Z = 8. Strong reflections of the powder XRD pattern [d,Å(I)(hkl)] are: 4.001(100)(121), 3.479(56)(023), 3.041(45)(042), 2.657(44)(200), 2.642(68)(142) and 2.613(36)(104). The crystal structure was solved from single-crystal XRD data and refined on powder data by the Rietveld method, Rwp = 0.0068, Rp= 0.0047 and Robs = 0.0435. Evseevite is isostructural to moraskoite Na2Mg(PO4)F. The structure of evseevite can be described in terms of anion-centred polyhedra. F-centred octahedra [FNa4Mg2]7+ share faces to form chains [FNa2Mg]3+ and AsO4 tetrahedra are located between the chains. Evseevite belongs to a small set of minerals with antiperovskite structures and is the first natural arsenate with antiperovskite units. The mineral is named in honour of the Russian mineralogist Aleksandr Andreevich Evseev (born 1949).
Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs
Authors: Mi Hui , Hu Fan , Gebeyew Kefyalew , Cheng Yan , Du Ruiping , Gao Min , He Zhixiong , Tan Zhiliang
Published: June 2023

Background

The liver is a principal metabolic organ and has a major role in regulating lipid metabolism. With the development of rapidly fattening livestock in the modern breeding industry, the incidence of hepatic steatosis and accumulation in animals was significantly increased. However, the molecular mechanisms responsible for hepatic lipid metabolic disturbances in a high concentrate diet remain unclear. The objective of this study was to evaluate the effects of increasing concentrate level in a fattening lamb diet on biochemical indices, hepatic triglycerides (TG) concentration, and hepatic transcriptomic profiles. In the present study, 42 weaned lambs (about 3 ± 0.3 months old) were randomly assigned to the GN60 group (60% concentrate of dry matter, GN60, n = 21) or GN70 group (70% concentrate of dry matter, n = 21) for a 3-months feeding trial.

Results

No difference was observed in the growth performance or plasma biochemical parameters between the GN60 group and the GN70 group. The hepatic TG concentration was higher in the GN70 group than GN60 group (P < 0.05). Hepatic transcriptomic analysis showed that there were 290 differentially expressed genes identified between GN60 and GN70 groups, with 125 genes up-regulated and 165 genes down-regulated in the GN70 group. The enriched Gene Ontology (GO) items and KEGG pathways and protein–protein interaction (PPI) network of differentially expressed genes (DEGs) revealed that the majority of enriched pathways were related to lipid metabolism. Further analysis revealed that the fatty acid synthesis was up-regulated, while fatty acid transport, oxidation, and TG degradation were down-regulated in the GN70 group when compared with the GN60 group.

Conclusions

These results indicated that GN70 induced excess lipid deposition in the liver of lambs during the fattening period, with high synthesis rates and low degradation rates of TG. The identified mechanisms may help understand hepatic metabolism in lambs with a high concentrate diet and provide insight into decreasing the risk of liver metabolism disorder in animals.
Factors related to the frequent use of emergency department services in Korea
Authors: Cho Eun Deok , Kim Bomgyeol , Kim Do Hee , Lee Sang Gyu , Jang Suk-Yong , Kim Tae Hyun
Published: June 2023

Background

Frequent Emergency Department (ED) visitors are identified by the policymakers to reduce avoidable ED visits and lessen the financial and operational burden. This study aimed to identify the factors related to the frequent use of ED services.

Methods

This nationwide, cross-sectional observational study was conducted using information obtained from the 2019 National Emergency Department Information System (NEDIS) database. Frequent ED users were defined as patients with four or more ED visits a year. We performed multiple logistic regression analyses to verify the relationship among sociodemographic characteristics, residential characteristics, clinical characteristics, and frequency of ED visits.

Results

Among 4,063,640 selected patients, 137,608 patients visited the ED four or more times a year (total number of visits = 735,502 times), which accounted for 3.4% and 12.8% of the total number of ED users and ED visits, respectively. A high ED visit frequency was associated with male sex, age < 9 or ≥ 70 years, Medical Aid (based on the insurance type), lower number of medical institutions and beds compared with that of the national average, and conditions, such as cancer, diabetes, renal failure, and mental illness. A low ED-visit frequency was associated with residence in regions vulnerable to emergency medical care and regions with high income. The possibility of frequent ED visits was high for patients with level 5 severity (non-emergent) and those with an increased need for medical treatment, including older patients and patients with cancer or mental illness. The possibility of frequent ED visits was low for patients aged > 19 years with level 1 severity (resuscitation).

Conclusions

Health service accessibility factors, including low income and medical resource imbalance, were associated with frequent ED visits. Future large-scale prospective cohort studies are warranted to establish an efficient emergency medical system.