bluuebunny/crossref_metadata_2025 huggingface dataset:
SRC kinase-mediated signaling pathways and targeted therapies in breast cancer
Authors: Luo Juan , Zou Hailin , Guo Yibo , Tong Tongyu , Ye Liping , Zhu Chengming , Deng Liang , Wang Bo , Pan Yihang , Li Peng
Published: December 2022

Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven members sharing similar structure and function. Among them, SRC is the first identified proto-oncogene in mammalian cells. Oncogenic overexpression or activation of SRC has been revealed to play essential roles in multiple events of BC progression, including tumor initiation, growth, metastasis, drug resistance and stemness regulations. In this review, we will first give an overview of SRC kinase and SRC-relevant functions in various subtypes of BC and then systematically summarize SRC-mediated signaling transductions, with particular emphasis on SRC-mediated substrate phosphorylation in BC. Furthermore, we will discuss the progress of SRC-based targeted therapies in BC and the potential future direction.
Focused Ultrasound and RadioTHERapy for non-invasive palliative pain treatment in patients with bone metastasis: a study protocol for the three armed randomized controlled FURTHER trial
Authors: Slotman Derk J. , Bartels Marcia M. T. J. , Ferrer Cyril J. , Bos Clemens , Bartels Lambertus W. , Boomsma Martijn F. , Phernambucq Erik C. J. , Nijholt Ingrid M. , Morganti Alessio G. , Siepe Giambattista , Buwenge Milly , Grüll Holger , Bratke Grischa , Yeo Sin Yuin , Blanco Sequeiros Roberto , Minn Heikki , Huhtala Mira , Napoli Alessandro , De Felice Francesca , Catalano Carlo , Bazzocchi Alberto , Gasperini Chiara , Campanacci Laura , Simões Corrêa Galendi Julia , Müller Dirk , Braat Manon N. G. J. A. , Moonen Chrit , Verkooijen Helena M. ,   on behalf of the FURTHER consortium
Published: December 2022

Background

Cancer-induced bone pain (CIBP), caused by bone metastases, is a common complication of cancer and strongly impairs quality of life (QoL). External beam radiotherapy (EBRT) is the current standard of care for treatment of CIBP. However, approximately 45% of patients have no adequate pain response after EBRT. Magnetic resonance image-guided high-intensity focused ultrasound (MR-HIFU) may improve pain palliation in this patient population. The main objective of this trial was to compare MR-HIFU, EBRT, and MR-HIFU + EBRT for the palliative treatment of bone metastases.

Methods/design

The FURTHER trial is an international multicenter, three-armed randomized controlled trial. A total of 216 patients with painful bone metastases will be randomized in a 1:1:1 ratio to receive EBRT only, MR-HIFU only, or combined treatment with EBRT followed by MR-HIFU. During a follow-up period of 6 months, patients will be contacted at eight time points to retrieve information about their level of pain, QoL, and the occurrence of (serious) adverse events. The primary outcome of the trial is pain response at 14 days after start of treatment. Secondary outcomes include pain response at 14 days after trial enrolment, pain scores (daily until the 21st day and at 4, 6, 12 and 24 weeks), toxicity, adverse events, QoL, and survival. Cost-effectiveness and cost-utility analysis will be conducted.

Discussion

The FURTHER trial aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU—alone or in combination with EBRT—compared to EBRT to relieve CIBP. The trial will be performed in six hospitals in four European countries, all of which are partners in the FURTHER consortium.

Trial registration

The FURTHER trial is registered under the Netherlands Trials Register number NL71303.041.19 and ClinicalTrials.gov registration number NCT04307914. Date of trial registration is 13–01-2020.
HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case–control study and a prospective nested case–control study
Authors: Liu Chunlan , Li Mengxia , Yin Qiming , Fan Yao , Shen Chong , Yang Rongxi
Published: December 2022

Background

Stroke is the leading cause of mortality in China. DNA methylation has essential roles in multiple diseases, but its association with stroke was barely studied. We hereby explored the association between blood-based HTRA serine protease 1 (HTRA1) methylation and the risk of stroke.

Results

The association was discovered in a hospital-based case–control study (cases/controls = 190:190) and further validated in a prospective nested case–control study including 139 cases who developed stroke within 2 years after recruitment and 144 matched stroke-free controls. We observed stroke-related altered HTRA1 methylation and expression in both case–control study and prospective study. This blood-based HTRA1 methylation was associated with stroke independently from the known risk factors and mostly affected the older population. The prospective results further showed that the altered HTRA1 methylation was detectable 2 years before the clinical determination of stroke and became more robust with increased discriminatory power for stroke along with time when combined with other known stroke-related variables [onset time ≤ 1 year: area under the curve (AUC) = 0.76].

Conclusions

In our study, altered HTRA1 methylation was associated with stroke at clinical and preclinical stages and thus may provide a potential biomarker in the blood for the risk evaluation and preclinical detection of stroke.
Neglected case of a huge leiomyoma in an elderly postmenopausal woman: a case report
Authors: Garg Priyanka , Bansal Romi
Published: December 2022

Background

Fibroids are benign tumors of the female reproductive tract originating from the myometrial smooth muscle cells. They are a frequent occurrence in women of childbearing age but their incidence is rare after menopause. In addition, there is a remote possibility of malignant transformation to leiomyosarcoma in less than 1% of cases.

Case presentation

We hereby report a case of large fibroid in a postmenopausal Indian female with rapid growth, raising the suspicion of malignant transformation into leiomyosarcoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology report confirmed it to be benign leiomyoma without any evidence of neoplasia.

Conclusion

Sudden enlargement of leiomyoma in postmenopausal women should not be ignored due to possible malignant transformation and is to be dealt immediately with hysterectomy followed by histopathology.
Computerized clinical decision support systems for prescribing in primary care: main characteristics and implementation impact—protocol of an evidence and gap map
Authors: Acosta-García Héctor , Ferrer-López Ingrid , Ruano-Ruiz Juan , Santos-Ramos Bernardo , Molina-López Teresa
Published: December 2022

Background

Computerized clinical decision support systems are used by clinicians at the point of care to improve quality of healthcare processes (prescribing error prevention, adherence to clinical guidelines, etc.) and clinical outcomes (preventive, therapeutic, and diagnostics). Attempts to summarize results of computerized clinical decision support systems to support prescription in primary care have been challenging, and most systematic reviews and meta-analyses failed due to an extremely high degree of heterogeneity present among the included primary studies. The aim of our study will be to synthesize the evidence, considering all methodological factors that could explain these differences, and build an evidence and gap map to identify important remaining research questions.

Methods

A literature search will be conducted from January 2010 onwards in MEDLINE, Embase, the Cochrane Library, and Web of Science databases. Two reviewers will independently screen all citations, full text, and abstract data. The study methodological quality and risk of bias will be appraised using appropriate tools if applicable. A flow diagram with the screened studies will be presented, and all included studies will be displayed using interactive evidence and gap maps. Results will be reported in accordance with recommendations from the Campbell Collaboration on the development of evidence and gap maps.

Discussion

Evidence behind computerized clinical decision support systems to support prescription use in primary care has so far been difficult to be synthesized. Evidence and gap maps represent an innovative approach that has emerged and is increasingly being used to address a broader research question, where multiple types of intervention and outcomes reported may be evaluated. Broad inclusion criteria have been chosen with regard to study designs, in order to collect all available information. Regarding the limitations, we will only include English and Spanish language studies from the last 10 years, we will not perform a grey literature search, and we will not carry out a meta-analysis due to the predictable heterogeneity of available studies.

Systematic review registration

This study is registered in Open Science Framework https://bit.ly/2RqKrWp
Urban expansion of Energiewende in Germany: a systematic bibliometric analysis and literature study
Authors: Yang Peter
Published: December 2022

Background

Despite Germany’s world leadership of Energiewende, there have been mounting challenges, such as the slowdown of German renewable energy growth since 2017, when the Merkel administration dramatically changed the German renewable energy promotion policy from feed-in tariffs to competitive auctions. These challenges pose important research questions about whether and how an emerging urban expansion of Energiewende can serve as a vital solution to counteract the challenges to the energy transition. Answering these research questions provides a unique opportunity to explore the academic and historic foundations of the energy transition and its urban expansion, the emerging events that exemplify urban expansion, and the viable solutions this growing trend of urban expansion might be able to provide to the challenges to the German energy transition.

Methods

This paper conducted visual and manual bibliometric analyses, examined the results of case studies, and reviewed secondary literature and data on urban expansion of German Energiewende.

Results

By analyzing the bibliometric and investigative results, this paper identified political, socioeconomic, and technological challenges to Energiewende and a new trend of solar energy expansion in German cities aimed at meeting Germany’s carbon neutrality targets by 2045. The new trend of the urban expansion of the German energy transition manifests itself in the focused research efforts on identifying the vast untapped potential on new building rooftop areas in most populous German cities and/or detached and two-family houses in Germany and the recent booming of building-related solar PV and heating mandates in German cities and states, the expanding solar heating and cooling systems, and the government policy support at various levels in this urban expansion through aggressively strengthening climate and renewable energy targets.

Conclusions

In search for answers to the recent challenges of Energiewende in Germany, this paper conducted both visual and manual bibliometric analyses and applied desk research and reviews of secondary literature and data. This paper found an emerging trend of the urban expansion of Energiewende, including the awareness of the vast potential and gap of urban solarization and the enhanced urban municipal policies, actors, actions, and accomplishments of exploiting this potential. These findings were based on academic knowledge on the German energy transition and contribute to expanding this academic knowledge. To help more effectively exploit the vast potential in solarizing all German cities, especially the largest ones, this study recommends that further research more closely track the progress of this trend and apply more quantitative tools and approaches in future tracking.
Toxico-clinical study of patients poisoned with household products; a two-year cross-sectional study
Authors: Eizadi-Mood Nastaran , Lalehzar Sahar Sadat , Niknam Sara , Mahvari Razieh , Mirmoghtadaee Parisa , Meamar Rokhsareh
Published: December 2022

Background

Several studies worldwide have investigated household product poisoning. We conducted a toxico-clinical study on the two-year prevalence of poisoning with household products.

Methods

This cross-sectional study was performed in Khorshid Hospital, the main referral center for poisoning cases in Isfahan, affiliated to Isfahan University of Medical Sciences, Isfahan, central Iran. All patients with intentional or unintentional household substance poisoning, referring to the poisoning emergency center of the hospital, were evaluated with respect to epidemiological and toxico-clinical features and outcomes.

Results

During the study period, 5946 patients were hospitalized, of which 83 (1.39%) had been poisoned with household products including 48 (57.8%) men and 35 (42.2%) women with a mean ± SD age of 34.40 ± 17.71 years. Most patients (54.2%) were in the 20–40-year-old age group. Accidental poisoning (63.9%) was the most common type of exposure (P = 0.02) predominantly in men (57.8%, P = 0.51). The most common household products were sodium hypochlorite (32.53%) followed by petroleum hydrocarbon (21.68%). Most of the accidental poisonings (77.8%) were due to petroleum hydrocarbon. 59% of cases were poisoned at home (P < 0.0001). No patient died.

Conclusion

Household products were not common means of poisoning in our referral center. Sodium hypochlorite and petroleum hydrocarbon were the most common substances. Most of the patients were men with accidental exposure at home. Because of the availability of the household product, the frequency and outcomes may be varied in different societies.
Budget impact analysis of breast cancer medications: a systematic review
Authors: Mohammadnezhad Ghader , Sattarpour Melika , Moradi Najmeh
Published: December 2022

Background

Breast cancer (BC) is the most common cancer globally among women, with 2,261,419 new cases in 2020; systemic treatment may be neo-adjuvant, adjuvant, or both. BC subtype guides the standard systemic therapy administered, which consists of endocrine therapy for all HR + tumors, trastuzumab-based HER2-directed antibody therapy plus chemotherapy for all HER2 + tumors (with endocrine therapy given in addition, if concurrent HR positivity), and chemotherapy alone for the triple-negative subtype. This study aimed to identify, evaluate, and systematically review all budget impact analyses (BIAs) of BC medications worldwide.

Methods

PubMed, Scopus, and Web of Science Core Collection databases were thoroughly searched up to 26th March 2022 to identify original published studies which evaluate BIA of BC medications. ISPOR Task Force guidelines were used to assess the quality of included studies. This study was conducted and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

In total, 17 BIAs were included in the study. About half of the studies were conducted in Europe. The results of the BIAs showed that most of the included BIAs are conducted from the payer’s perspective; they have different methodological frameworks for recommended chemotherapy, targeted therapy, and immunotherapy agents to treat BC. For the same medications, the results of budgetary effects are not consistent in diverse countries. Nine out of the 17 studies were focused on trastuzumab, in which the biosimilar form reduced costs, but the brand form increased costs, especially in a 52-week treatment period.

Conclusion

Researchers should conduct the budget impact analysis of high-value medications such as anti-tumor drugs more objectively, and the accuracy of parameters needs to be more strictly guaranteed. Furthermore, it is worthy of declaring that the budgetary impact of the same drug is not always consistent over time, so the researchers should measure access to medication in the long run.
Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis
Authors: Ghobrial Emad E. , Galal Rasha E. , Gadass Maha S. , Shaalan Yomna M.
Published: December 2022

Background

Growth and pubertal retardation are one of the most visible comorbidities in children with chronic kidney disease (CKD) and end-stage renal disease (ESRD) under regular hemodialysis. This study evaluated pubertal development in children and adolescents with CKD and ESRD on regular hemodialysis.

Methods

This study was carried out on 40 children with CKD and 20 with ESRD under regular hemodialysis. All patients and controls were subjected to a thorough clinical examination pubertal assessment.

Results

There was a statistically significant difference in the breast or testicular stage of the three groups (P < 0.001). Most cases of ESRD were either stages 1 or 2 (50.0%, 45.0%, respectively). The CKD cases were also stages 1 and 2 (35.7%, 52.4%, respectively). The controls were in stages 3 and 4 (44.3 and 29.5%, respectively), which showed normal development for age. There was a statistically significant difference in the pubic hair stage and axillary hair stage of the three groups (P < 0.001). Most cases of ESRD were either stages 1 or 2 (55.0%, 40.0%, respectively). The CKD cases were also between stages 1 and 2 (38.1%, 52.4%, respectively), with a higher level in stage 2. Of the control group, 39.3% was stage 3, and 36.1% was stage 4, with a higher level in stage 3 proving normal development for age.

Conclusion

Pubertal growth and sexual maturation in children with CKD and ESRD are markedly affected. It is necessary to regularly follow up with children with ESRD for early detection of endocrinal complications.
Vanillic acid attenuates testicular ischemia/reperfusion injury in rats
Authors: Mentese Ahmet , Demir Selim , Kazaz Ilke Onur , Yulug Esin , Alemdar Nihal Turkmen , Demir Elif Ayazoglu , Kartal Mehmet Baris , Durmus Tenzile Beyza , Aliyazicioglu Yuksel
Published: December 2022

Background

Testicular torsion is an important pediatric problem and ischemia/reperfusion injury (IRI) is involved in its etiopathogenesis. Vanillic acid (VA) is a phenolic acid has strong antioxidant properties. To our knowledge, the ability of VA to reduce testicular IRI has not been previously investigated. It was therefore aimed to evaluate whether VA had a beneficial effect against testicular IRI model in rats for the first time. Twenty-four rats were segregated into four groups: sham control, torsion/detorsion (T/D), T/D + VA (50 mg/kg and 100 mg/kg). The levels of testicular oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis markers were determined using colorimetric methods. Hematoxylin–eosin staining method was used in the histopathological evaluation.

Results

Oxidative stress, inflammation, ER stress and apoptosis levels were significantly higher in testicular tissues of rats with only IRI model (p < 0.05). VA applications improved these injuries in a dose-dependent manner (p < 0.05). Moreover, it was found that the results of histological examinations supported the biochemical results to a statistically significant extent.

Conclusions

It was revealed that VA application can remove testicular IRI for the first time. This testicular protective efficacy of VA needs to be supported by more extensive preclinical studies.
An empirical investigation into people’s intention to participate in mega events tourism: applying mixture of two behavioral theoretical models
Authors: Halim Yasser Tawfik , Halim Hazem Tawfik , El-Deeb Mohamed Samy , El Sheikh Samia Adly
Published: December 2022

The purpose of this research is to build and evaluate a theoretical model capable of forecasting public participation in mega events. This study predicts event tourism participation using a mixed behaviour model based on a trust model and a deliberate actions model. Using data from 261 local and international visitors, structural equation modelling was engaged to examine the study hypotheses. According to the study's results, observed benefits were positively connected with people’s perspective, but observed obstacles were negatively associated, and observed benefits had a positive influence on interactive mechanism and observed obstacles had a negative influence on interactive mechanism. Additionally, the study's results suggested that individuals' intention to participate in mega events was positively influenced by their observed benefits, perspective, interactive mechanism, and normative beliefs and negatively influenced by observed obstacles. Finally, we perceived that observed risk significantly moderated the associations between observed benefits, observed obstacles and perspective, observed benefits, observed obstacles and interactive, lastly, observed benefits, observed obstacles, perspective, interactive mechanism, normative beliefs and intention to participate in events. The research's outcomes have significant hypothetical and applied effects for mega-events travel.
Dynamic Risk Stratification for Predicting Long-term Outcomes in Pediatric Differentiated Thyroid Cancers
Authors: Majeed Althaf K , Satapathy Swayamjeet , Ballal Sanjana , Bal Chandrasekhar
Published: December 2022

Context

The American Thyroid Association (ATA) guidelines recommend Dynamic Risk Stratification (DRS) for predicting long-term outcomes and personalizing management in adult differentiated thyroid cancers (DTCs). However, its applicability in pediatric DTCs needs to be validated.

Objective

We have attempted a validation study concerning the use of DRS in pediatric DTCs.

Methods

Data of children (age ≤18 years) with DTCs and follow-up of ≥5 years were extracted. All patients were classified according to DRS (excellent biochemical or structural incomplete responses). Univariate and multivariate analyses were done to identify factor(s) affecting disease-free survival (DFS).

Results

We included 176 pediatric patients with DTC (median age at diagnosis 15 years). All patients underwent thyroidectomy and received radioiodine as part of initial management. On the basis of clinical, biochemical, and imaging findings acquired during the first 2 years of follow-up, the DRS system divided patients into 3 response categories: excellent response in 82/176 (46.6%), biochemical incomplete response in 56/176 (31.8%), and structural incomplete response in 38/176 (21.6%) patients. The median follow-up was 10.6 years (interquartile range 7.7-15.5). Ten-year overall survival and DFS rates were 100% and 88.7%, respectively. In univariate analysis, DFS was significantly affected by extrathyroidal extension (P = .002), lymph node metastasis (P = .018), ATA initial risk stratification (P = .033), and DRS (P = .004). However, in multivariate analysis, DRS alone showed a significant association with DFS (P = .016).

Conclusion

Like adults, DRS correctly predicts long-term outcomes in pediatric DTC. In addition to ATA initial risk stratification, DRS could further refine risk in pediatric DTCs and help in planning more personalized treatment and follow-up strategies.
Stress, Anxiety, and Depression Associated With Awake Craniotomy: A Systematic Review
Authors: Mofatteh Mohammad , Mashayekhi Mohammad Sadegh , Arfaie Saman , Chen Yimin , Hendi Kasra , Kwan Angela Tian Hui , Honarvar Faraz , Solgi Arad , Liao Xuxing , Ashkan Keyoumars
Published: December 2022

BACKGROUND:

Awake craniotomy (AC) enables real-time monitoring of cortical and subcortical functions when lesions are in eloquent brain areas. AC patients are exposed to various preoperative, intraoperative, and postoperative stressors, which might affect their mental health.

OBJECTIVE:

To conduct a systematic review to better understand stress, anxiety, and depression in AC patients.

METHODS:

PubMed, Scopus, and Web of Science databases were searched from January 1, 2000, to April 20, 2022, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline.

RESULTS:

Four hundred forty-seven records were identified that fit our inclusion and exclusion criteria for screening. Overall, 24 articles consisting of 1450 patients from 13 countries were included. Sixteen studies (66.7%) were prospective, whereas 8 articles (33.3%) were retrospective. Studies evaluated stress, anxiety, and depression during different phases of AC. Twenty-two studies (91.7%) were conducted on adults, and 2 studies were on pediatrics (8.3 %). Glioma was the most common AC treatment with 615 patients (42.4%). Awake-awake-awake and asleep-awake-asleep were the most common protocols, each used in 4 studies, respectively (16.7%). Anxiety was the most common psychological outcome evaluated in 19 studies (79.2%). The visual analog scale and self-developed questionnaire by the authors (each n = 5, 20.8%) were the most frequently tools used. Twenty-three studies (95.8%) concluded that AC does not increase stress, anxiety, and/or depression in AC patients. One study (4.2%) identified younger age associated with panic attack.

CONCLUSION:

In experienced hands, AC does not cause an increase in stress, anxiety, and depression; however, the psychiatric impact of AC should not be underestimated.
Reference Vector Assisted Candidate Search with Aggregated Surrogate for Computationally Expensive Many Objective Optimization Problems
Authors: Wang Wenyu , Shoemaker Christine A.
Published: December 2022

Pareto-optimal sets of multiobjective optimization problems with black-box and computationally expensive objective functions are generally hard to locate within a limited computational budget, and this situation gets even worse when more than three objectives are involved. To this end, we present a novel surrogate-assisted many-objective optimization algorithm RECAS. Unlike most prior studies, the proposed algorithm is a non–evolutionary-based method, and it iteratively determines new points for expensive evaluation via a series of independent reference vector assisted candidate searches. Furthermore, to make the number of surrogates to be maintained independent of the number of objectives, in each candidate search, RECAS constructs a surrogate model in an aggregated manner to approximate the quality assessment indicator of each point rather than a certain objective function. Under some mild assumptions, this study proves that RECAS converges almost surely to the Pareto-optimal front. In the numerical experiments, the effectiveness and reliability of RECAS are examined on both DTLZ and WFG test suites with the number of objectives varying from 2 to 10. Compared with six state-of-the-art many-objective optimization algorithms, RECAS generally performs better in maintaining convergent and well-spread approximation of the Pareto-optimal front. Finally, the good performance of RECAS on two watershed simulation model calibration problems indicates its great potential in handling real-world applications.

History: Accepted by Antonio Frangioni, Area Editor for Design and Analysis of Algorithms–Continuous.

Funding: This work was supported by the National University of Singapore start-up grant to C.A. Shoemaker [Grant R-266-000-109-133].

Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplementary Information [ https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1260 ] or is available from the IJOC GitHub software repository ( https://github.com/INFORMSJoC ) at [ http://dx.doi.org/10.5281/zenodo.7243971 ].
Optimizing User Engagement Through Adaptive Ad Sequencing
Authors: Rafieian Omid
Published: December 2022

This paper develops an offline reinforcement learning framework that identifies and evaluate the ad sequencing policy that optimizes user engagement.
The Utilization Premium
Authors: Grigoris Fotis , Segal Gill
Published: December 2022

We study the interaction of flexible capital utilization and depreciation for expected returns and investment of firms. Empirically, an investment strategy that buys (sells) equities with low (high) utilization rates earns 5% per annum. Utilization predicts excess returns beyond other production-based variables. We reconcile this novel utilization premium quantitatively using a production model. The model suggests that flexible utilization is important for matching the cross-sectional distribution of investment and stock prices jointly. A model without flexible utilization yields many counterfactuals that flexible utilization addresses by making depreciation fluctuate endogenously. Overall, utilization tightens the link between firms’ production and valuations.

This paper was accepted by Lukas Schmid, finance.

Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4647 .
Non-Episodic Angioedema Associated with Eosinophilia after COVID-19
Authors: Harada Taku , Kosaka Shintaro , Nakai Mori
Published: December 2022

ntroduction: Non-episodic angioedema associated with eosinophilia (NEAE) has been reported primarily in young East Asian women and is characterized by a single episode of persistent limb oedema, peripheral eosinophilia, and transient joint pain. Although there are reports of eosinophilia disease after coronavirus disease 2019 (COVID-19), the occurrence of NEAE has not been previously reported. Case description: A 29-year-old Japanese woman, with a history of allergic rhinitis and atopic dermatitis, sought a medical consultation for persisting oedema of the extremities, which developed about 2 weeks after she contracted COVID-19. Physical examination revealed symmetrical non-pitting oedema with peripheral predominance. Laboratory examination revealed a blood eosinophil count of 7536/µl. The patient was diagnosed with NEAE and a 7-day course of prednisolone (15 mg/day) was initiated, with rapid improvement in the oedema and no recurrence on follow-up. Discussion: The exact aetiology of NEAE is unknown, but it may develop after infection or drug exposure. Eosinophilic disease after COVID-19 infection has been reported and, therefore, eosinophilic angioedema should be considered in the differential diagnosis of non-pitting oedema of the extremities after a COVID-19 infection. Early diagnosis of NEAE is important as rapid improvement can be achieved with low-dose steroid treatment.  Conclusion: NEAE can develop after COVID-19 and should be considered in the differential diagnosis of non-pitting oedema of the extremities.
Attitudes about Cybersecurity Articulation Agreements and Transfer Students: A Statewide Survey of Faculty Members and Advisors
Authors: Payne Brian K. , Vandecar-Burdin Tancy , Cigularova Daniela
Published: December 2022

In this study, cybersecurity faculty and academic advisors from community colleges and 4-year universities in the southeast region of the United States completed a survey assessing attitudes about and support for articulation agreements and related transfer policies. Hypothesizing that professional structures shape attitudes and experiences, the researchers conducted an exploratory quantitative study with primarily descriptive analyses. The results reveal differences in attitudes between community college and 4-year stakeholders and between faculty and academic advisors. The results of this study are discussed in relation to faculty and advisor training and communication.
Online Graduate Career Changers: Motivations and Use of Academic and Career Advising Services and Resources
Authors: Talbott Katelyn
Published: December 2022

This work expands the literature and research focused on career change students enrolled in an online master's program by examining the literature regarding transitions, motivations, and advising support for career changers. Also studied are the motivations of career change students enrolled in two different online, synchronous graduate programs. The study outlined offerings to this special population in terms of full-time primary role academic and career advising. It was found that participants utilized personalized communications and orientation programming provided by academic and career advising.
Practitioner Inquiry to Develop Antiracist Advising Practice: Investigating Issues of Equity and Access
Authors: Chimel Mark , Hurst Heather
Published: December 2022

In the field of academic advising, the advising and retention of students of color are of particular concern. Academic advisors can utilize practitioner inquiry to better understand the (in)equities in their interactions with and in service to these students. Our inquiry was conducted over one semester at a Predominantly White Institution (PWI) in the mid-Atlantic region. We utilized practitioner inquiry groups and the Equity Scorecard to identify antiracist actions in our advising practice, including supporting students' connectivity to support services on campus and advocating for changes to inequitable campus systems. The implications demonstrate why advisors may conduct a similar inquiry on their advising practice. The findings further emphasize the importance of proactive approaches and modeling advocacy in prior advising studies.
Increasing Access and Enhancing Transition Experiences of Transfer Students in a 2+2 Program: A Descriptive Case Study
Authors: McGill Craig M. , Lazarowicz Tony
Published: December 2022

Transfer agreements between institutions have existed for decades, but a newer 2+2 model provides pathways to bachelor's degree completion for students who initially applied to 4-year institutions but were not admitted. Most literature on these programs focuses on how articulation agreements and dual-admissions processes provide a gateway to baccalaureate degree attainment. Scant academic literature has focused on how institutional partnering programs facilitate the transfer process for students. This descriptive case study examined one dual-admission transfer program at a large Hispanic-Serving Institution and offers implications for practice, future research, and program design.
Alagille Syndrome Nowadays: “One, no-One and One Hundred Thousand”
Authors: Arrabito M. , D’Amico S. , Gulizia C. , Marino L. , Parisi G.F. , Papale M. , Manti S. , Leonardi S.
Published: December 2022

Alagille syndrome [ALGS] is an autosomal dominant, complex multisystem disorder that includes a wide range of clinical aspects, most commonly manifest in infancy or early childhood. It is mostly caused by mutations of genes involved in the Notch signaling pathway. The major of clinic manifestations occur in liver, but also other organs, like heart, eye and skeleton can be impaired. Herein we report the story of a family in which four members were diagnosed with ALGS, leading the same gene mutation. The peculiarity of our case lies in the fact that they manifested the disease in different time of their life and with many different symptoms, highlighting the impressive clinical variability of the ALGS and the importance of considering it in the differential diagnosis of liver impairment disease.
Usefulness of the Berlin Questionnaire for Screening Patients With Obstructive Sleep Apnea
Authors: Yang Hyunju , Yoo Sung-Hee
Published: December 2022

Objectives: This study aimed to evaluate the usefulness of the Berlin questionnaire (BQ) as a screening tool for obstructive sleep apnea (OSA) in a sleep clinic.Methods: We used a retrospective review of 77 subjects with suspected OSA to conduct a secondary analysis of a previously published sleep study. A total of 77 subjects attended and completed overnight, in-laboratory polysomnography. Subjects completed the standard BQ in the evening just before the sleep study.Results: The mean age of 77 subjects was 49.94±15.78 years, of which 37 (48.1%) were male and 42 (63.7%) were white. Forty-six subjects (59.7%) were diagnosed with OSA through polysomnography. In the analysis of each item of the standard BQ, the sensitivity ranged from 4.6% to 92.5%, and the specificity ranged from 13.3% to 85.7%. For item 8, the sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 4.6%, 84.9%, 0.3, and 1.1, respectively. The area under the curve values of the standard BQ and after deleting item 8 were 0.634 and 0.751, respectively. When item 8 was deleted and each item on the standard BQ was calculated as one point, the cutoff values representing the highest Yuden index were 3.5 and 4.5.Conclusions: A modified BQ that selects four different questions for each subject, regardless of the number of positive categories in the standard BQ, will provide improved accuracy in screening subjects with a high likelihood of having OSA.
A Case of Seizure Like Movement During Rapid Eye Movement Sleep Diagnosed With Pseudo-Rapid Eye Movement Sleep Behavior Disorder Associated With Severe Obstructive Sleep Apnea
Authors: Park Soo Ryun , Bae Hyoeun , Joo Eun Yeon
Published: December 2022

Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by complex motor behaviors and REM without atonia. RBD shows diverse clinical manifestations, ranging from typical violent dreamenacting behaviors to relatively subtle limb movements. Sleep disorders such as obstructive sleep apnea (OSA) and nocturnal seizure that mimic RBD symptoms are referred to as pseudo-RBD. We describe a patient who showed an atypical clinical presentation of pseudo-RBD associated with severe OSA. Polysomnography with a full 10–20 electroencephalography montage was useful for accurate diagnosis.
Sleep-Related Head Jerk Presenting With Dream Enactment Behavior: A Case Report
Authors: Shin Jung-Won
Published: December 2022

Sleep-related head jerk (SRHJ) is conceived as a physiological motor phenomenon, which is mostly seen during rapid eye movement (REM) sleep. It should be distinguished from movements during REM sleep, mainly REM sleep behavior disorder (RBD). A 25-year-old male complained of daytime sleepiness with snoring and dream enactment behavior (DEB). Video polysomnography (PSG) excluded RBD and obstructive sleep apnea; frequent SRHJs during REM sleep with or without respiratory effort-related arousals, and SRHJs followed by one episode of DEB was observed. On PSG with continuous positive airway pressure titration, SRHJ with arousal events still remained but DEB symptom was resolved. REM without atonia unrelated to head jerks was not observed on all PSG data. Excessive SRHJs with arousal related to a sleep disturbance could indicate an SRHJ disorder, which might be a novel sleep-related movement disorder. In addition, clinicians should be careful in diagnosing young patients with RBD.
The Oxygen Desaturation Index for Severity Assessment of Obstructive Sleep Apnea Associated With Cigarette Smoking
Authors: Lee Sujin , Seong Min Jae , Joo Eun Yeon
Published: December 2022

Objectives: Nicotine stimulates release of neurotransmitters that regulate the sleep-wake cycle and thereby leads to insomnia. Smoking is associated with upper airway distress; however, its role in severe sleep-related breathing disorders remains controversial. In this study, we investigated the effects of smoking on obstructive sleep apnea (OSA).Methods: We investigated 1,163 patients diagnosed with OSA who underwent polysomnography between March 2020 and July 2022. We recorded details including smoking status (current, former, and non-smoker), demographics, questionnaire-related data, and polysomnography findings and performed univariate analysis to compare these variables between smokers and non-smokers. We also analyzed the correlation between smoking status and OSA severity. The risk of smoking on the severity of OSA was determined using logistic regression analysis.Results: Current and former smokers included 461 male (49.1%) and 10 female (4.4%) (p=0.001). Smokers had a high apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) (p<0.001), high arousal index (p=0.001), and severe daytime sleepiness (indicated by the Epworth Sleepiness Scale, p<0.001). We observed no correlation between the AHI and the number of cigarettes smoked per day and the duration of smoking. Logistic regression analysis after adjustment for age, sex, body mass index, and alcohol consumption showed that smoking was a risk factor for ODI (ODI >15, odds ratio 1.33, p=0.04), and AHI was independent of smoking.Conclusions: Controversy regarding the severity of OSA with smoking has currently not been definitively determined. However, our results provide new evidence to support the association between smoking and the ODI, which few studies have investigated to date.
Near-field circular dichroism of single molecules
Authors: Yamane Hidemasa , Yokoshi Nobuhiko , Oka Hisaki , Sugawara Yasuhiro , Ishihara Hajime
Published: December 2022

Near-field images of molecules provide information about their excited orbitals, giving rise to photonic and chemical functions. Such information is crucial to the elucidation of the full potential of molecules as components in functional materials and devices at the nanoscale. However, direct imaging inside single molecules with a complex structure in the near-field is still challenging because it requires in situ observation at a higher resolution than the molecular scale. Here, using a proven theoretical method that has demonstrated sub-nanoscale resolution based on photoinduced force microscopy (PiFM) experiment [Nat. Commun. 12, 3865 (2021)10.1038/s41467-021-24136-2], we propose an approach to obtaining the near-field imaging with spatial patterns of electronic transitions of single molecules. We use an extended discrete dipole approximation method that incorporates microscopic nonlocal optical response of molecules and demonstrate that PiFM can visualize circular-dichroism signal patterns at sub-nanometer scale for both optically allowed and forbidden transitions. The result will open the possibility for the direct observation of complex spatial patterns of electronic transitions in a single molecule, providing insight into the optical function of single molecules and helping realize new functional materials and devices.
Tunable dual optical frequency comb at 2 μm for CO2 sensing
Authors: Russell E. , Ruth A. A. , Corbett B. , Garcia Gunning F. C.
Published: December 2022

In this article, we demonstrate a dual frequency comb (DFC) based on the gain-switching of mutually injection-locked semiconductor lasers in the 2 μm wavelength region with a tunable free spectral range (FSR) between 500 MHz and 3 GHz. Through the down-conversion process enabled by DFCs, the beating spectra of the optical frequency combs were captured in a 15 MHz electrical bandwidth with high resolution and millisecond acquisition times. A first experimental demonstration of sensing CO2 with this architecture is also presented.
Hiding private information in private information protection liquid crystal displays using periodical waveplates and pixel quaternity
Authors: Liu Cheng-Kai , Chang Shu-Ching , Juang Yung-Shiang , Cheng Ko-Ting
Published: December 2022

A method to hide private information (PI) in private information protection liquid crystal displays (PIPLCDs) using periodical waveplates and pixel quaternity is reported in this study. The PIPLCD structure and its operation mechanism are conceptually elucidated. Users employing wide-view broadband circular polarizers (WVBCPs) can see PI hidden in images displayed on the PIPLCDs in PIP mode. However, people who do not use WVBCPs can only see the displayed images but not the PI at almost any viewing angles. The issues of the PIPLCD in PIP mode and possible fabrications of the periodical waveplates are also discussed.
Upgraded Cherenkov time-of-flight detector for the AFP project
Authors: Nozka Libor , Avoni Giulio , Banas Elzbieta , Brandt Andrew , Cerny Karel , Davis Paul M. , Duarte Pinto Serge , Georgiev Vjaceslav , Hrabovsky Miroslav , Komarek Tomas , Korcyl Krzysztof , Lopez-Paz Ivan , Milovanovic Marko , Mladenovic Goran , Orlov Dmitry A. , Rijssenbeek Michael , Schovanek Petr , Sykora Tomas , Trzebinski Maciej , Urbasek Vladimir , Zich Jan
Published: December 2022

We present the results of our performance studies of the upgraded Cherenkov time-of-flight (ToF) detector for the AFP (ATLAS Forward Proton) project. The latest version consists of solid L-shaped fused silica bars, new customized ALD-coated micro-channel plate photomultipliers (MCP-PMTs) miniPlanacon XPM85112-S-R2D2 with an extended lifetime which operate at low gains (order of 103), and an updated construction. The improvements were aimed to increase the efficiency, the lifetime as well as the radiation hardness of the detector which has been designed to operate in high radiation areas (above 400 kGy/year). The detector was finally tested at the CERN-SPS test-beam facility (120 GeV π+ particles) in August 2021 prior to its installation at the Large Hadron Collider (LHC) at CERN. Measurements proved the detector kept its inner timing resolution of 20 ps despite the rather low gain of its photodetector and reduced optical throughput caused by inevitable changes in the detector geometry.
Supermode Bragg grating inscribed in a strongly coupled seven-core fiber and its responses to temperature and curvature
Authors: Dong Xian , Xie You-Hang , Ou Jia-Le , Wu Chuang , Li Jie , Guan Bai-Ou
Published: December 2022

A Bragg grating is successfully inscribed in a piece of strongly coupled seven-core fiber (SCF). There are two separate Bragg resonance notches observed in the transmission spectrum, corresponding to backward coupling of HE11-like and HE12-like supermodes of the SCF. The mode coupling mechanism of the Bragg grating is theoretically investigated via modeling and analyzing modal properties of the SCF. The theoretical results agree well with the experimental results. Since the SCF is spliced between two standard single mode fibers with central alignments at both ends, the transmission spectrum of the device also contains a set of interference fringe due to modal interference between the supermodes. The device’s responses to temperature and curvature are experimentally measured, respectively. The obtained temperature sensitivities and curvature sensitivities of the supermode Bragg grating notches are 9.55 pm/°C and 9.55 pm/°C, −1.8 pm/m−1 and −112.3 pm/m−1, respectively. The obtained temperature sensitivity and curvature sensitivity of one of the interference spectrum dips are 11.8 pm/°C and −3909.8 pm/m−1, respectively. This device is potentially useful for simultaneous measurement of temperature and curvature.