bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical characterizations of synthetic nano PcGaCl thin film. In vitro, hemocompatibility, cytotoxicity, and PDT valuation
Authors:   ME-physics master program, Department of Physics, Faculty of Science, University of Tabuk, KSA, Al-Qaissi H. , Al-qarni Y. ,   ME-physics master program, Department of Physics, Faculty of Science, University of Tabuk, KSA, Al-Aniezi A. ,   ME-physics master program, Department of Physics, Faculty of Science, University of Tabuk, KSA, Elblbesy M. A. ,   Department of Medical Laboratory Technology, Faculty of Applied Medical Science, University of Tabuk, KSA, Hamdalla T. A. ,   Department of Physics, Faculty of Science, University of Tabuk, KSA, Darwish A. A. A. ,   Department of Physics, Faculty of Science, University of Tabuk, KSA, Moustafa M. E. ,   Department of Medical Biophysics, Medical Research Institute, Alexandria University, Egypt
Published: September 2022

Doped Phthalocyanines compounds are very applicable materials that have been utilized in different fields of industry and medicine such as photovoltaic, fuel cell, and photodynamic therapy. Here, we report the optical, cytotoxicity, and PDT evaluation of PcGaCl thin film. The optical studies show that the investigated thin film has a high light abortion at a wavelength of 500 nm. the energy gap of PcGaCl thin film has been evaluated using the WDD model and it was found to be 3.9 eV. The hemocompatibility and cytotoxicity studies of PcGaCl thin film have been evaluated in Caco-2, melanoma, and fibroblast. PcGaCl thin film showed no cytotoxicity in the dark. Upon exposure to different radiation doses of 2.5 J/cm2, 4.5 J/cm2, and 8.5 J/cm2, PcGaCl thin film has exhibited a high photocytotoxicity. The result suggests that Ga(III)Cl thin film can be considered a promising photosensitizer for Photodynamic therapy (PDT).
Morphological and optical properties of MgO1-xZnSx thin films
Authors:   Physics Department ,College of Science, Diyala University, Diyala, Iraq, Al-Rikabi H. S. , Al-Timimi M. H. ,   Physics Department ,College of Science, Diyala University, Diyala, Iraq, Albanda W. H. ,   Science Department - College of Basic Education - Al-Mustansiriya University, Iraq
Published: September 2022

(MgO) films doped with (ZnS) were prepared using a spray pyrolysis technique. Thin films were deposited on glass substrates at (350°C) with different concentrations (0,2,4,6,8) % of ZnS to study the surface morphology and optical properties. The (AFM) images indicated that increasing the (ZnS) concentrations leads to a decrease in the surface roughness rate. The optical measurements showed a decrease in the transmittance and reflectivity spectrum of all the prepared films, with an increase in (ZnS) concentrations and an increase in the absorption coefficient, refractive index, and extinction coefficient. The values of the real part of the dielectric constant were higher compared to the imaginary part for all the prepared films. Also, the optical energy gap decreased with the increase of (ZnS) concentrations within the range of (2.771-2.549) eV.
Visible light photocatalyticdye degradation activity of Fe3+, Co2+, Mn2+ and Zn2+ mononuclear complexes derived from O-vanillin bidentate schiffbase ligands
Authors:   Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan, Jaan A. , Iqbal W. ,   Department of Chemistry and Chemical Technologies, University of Calabria, 87036 Rende, Cosenza, Italy, Shahzad B. ,   Soochow Institute for Energy and Materials Innovations, College of Energy, Soochow University, Suzhou 215006, China, Iqbal Y. ,   Department of Chemistry, Government College University Faisalabad-38000, Pakistan, Rehman M. U. ,   Soochow Institute for Energy and Materials Innovations, College of Energy, Soochow University, Suzhou 215006, China, Haider I. ,   Materials Modeling Laboratory, Department of Physics, Hazara University, Mansehra, Pakistan, Javid M. T. ,   Department of Chemistry, Rawalpindi Women University Rawalpindi, 46300, Pakistan, Anwar U. ,   Soochow Institute for Energy and Materials Innovations, College of Energy, Soochow University, Suzhou 215006, China
Published: September 2022

O-Vanillin derived schiff base ligands were synthesized with 1,3-diaminapropane and oxamidei.e L1 and L2. These schiff base ligands were then used to synthesize mononuclear schiff base metal complexes by treating them with Fe3+, Co2+,Mn2+and Zn2+ metal salts, giving L1Fe, L1Co, L1Zn and L2Co, L2Mn metal complexes. L1 and L2ligandsand L1Fe, L1Co, L1Zn and L2Co, L2Mn metal complexes were characterized by FT-IR, UV-vis and PXRD. The synthesized metal complexes were used against rhodamine blue (RB) dye for their comparative study of degradation properties. Among the synthesized complexes L1Co showed maximum degradation of RB after 70 min of interval of about 56.835% whereas, the degradation property shown by L1Zn, L1Fe, L2Co and L2Mn is 42.446%, 32.733%, 20.863% and 13.309% respectively. The order of degradation of RB by all the metal complexes is as follows; L1Co> L1Zn> L1Fe> L2Co> L2Mn.
Starch-capped silver oxide (Ag2O) nanoparticles: synthesis, characterization and antibacterial activity
Authors:   University of KwaZulu Natal, Department of Chemistry, Private Bag X021, Scottsville, 3209, South Africa, South Africa, Mahlambi P. N. , Moloto M. J. ,   Institute for Nanotechnology and Water Sustainability, College of Science, Engineering and Technology, University of South Africa, Florida Park, Roodeport, 1709, South Africa
Published: September 2022

Silver oxide nanoparticles were synthesized at room temperature using a green synthetic method and water as a solvent. Starch was used as a capping and reducing agent because it is cheap, non-toxic and environmentally friendly. The effect of precursor and capping agent concentrations were investigated. The nanoparticles have been characterized using spectroscopic and morphological techniques. The spectrum of Ag2O nanoparticles showed the maximum absorbance range at 350-366 nm. TEM analysis showed a size particle range of 2-14 nm. The increase in precursor concentration showed an increase in particle size while increasing the capping agent concentration resulting in reduced particle size. Increased capping concentration also resulted in the change to nanofibers. The nanoparticles showed antibacterial activities against both Staphylococcus aureus and Escherichia coli strains. The 2:1 Ag2O ratio showed the best activity towards both strains, 15 ± 0.19 and 14 ± 0.11 mm diameter, respectively.
A preliminary study on the reactive suspension approach to create bioactive polymer nanocomposites for dental applications
Authors:   Department of Mechanical Engineering, Kumaraguru College of Technology, Coimbatore - 641049, Tamil Nadu, India, Arun K. K. , Rajeshkannan S. ,   Department of Electronics and Communication Engineering, St. Joseph’s College of Engineering, OMR, Chennai - 600119, Tamil Nadu, India., Ezhilarasi P. ,   Department of Electronics and Communication Engineering, St. Joseph’s College of Engineering, OMR, Chennai - 600119, Tamil Nadu, India., Natrayan L. ,   Department of Mechanical Engineering, Saveetha School of Engineering, SIMATS, Chennai, Tamil Nadu, India.
Published: September 2022

The modified chemical particle with appropriate combination agents possesses a lesser surface and the organic matrix gives more compatibility with the unprocessed matrix, is a typical strategy for limiting agglomeration problems. The limited time processing was the main sign of the chemical modification and particle purification. The production of nanoparticles directly inside the organic matrix is an alternate technique in situ approach. The present studies focused to make a new nanocomposites matrix with powder and liquid phase PMMA and hydroxyethyl methacrylate and it is processed by in-situ method to compose the hydroxyapatite nanoparticles of (Ca10(PO4)6(OH)2. Therefore reactive suspension approach was utilized in this study. During the in-situ process, the precursors like ammonium dihydrogen and calcium nitrate tetrahydrate are used. When the combinations of HA with the influence of the HEMA agent. These precursors and the agents composed the hybrid material with even dispersion. Due to maximum phase interrelations were achieved between the dead filler and polymer matrix base. HA is an inorganic phase that is osteogenic and osteoconductive, comparable to bone-based minerals. Similarly, it promotes polymer-based composites from bioactivity to enhance bone regeneration. The structure and morphology characteristics of PMMA, hydroxyethyl methacrylate and HA processed composites are examined in this work. The mechanical characteristics of the composites are measured in the combinational mode of compression and flexural. Then the bioactivity is investigated by submerging into the simulated bodily fluid (SBF). The mixing among the HA and polymer reduces the water sorption values significantly. After soaking in simulated bodily fluid, the surface of the HA generation was verified into the bioactivity of the processes composites.
Hydrothermal synthesis, characterization and antimicrobial activity of Ag-modified ZnO nanoplates against pathogen
Authors:   Department of Physics, Hazara University Mansehra, Mansehra, 21300, Pakistan, Ullah A. , Toufiq A. M. ,   Department of Physics, Hazara University Mansehra, Mansehra, 21300, Pakistan, Qureshi M. T. ,   Department of Basic Sciences, College of Preparatory Year, University of Ha’il, Ha’il 2440, Kingdom of Saudi Arabia, Khan A. ,   Department of Physics, Hazara University Mansehra, Mansehra, 21300, Pakistan, Younas M. ,   Department of Microbiology, Government College University Faisalabad, Pakistan, Obeidat S. T. ,   Department of Basic Sciences, College of Preparatory Year, University of Ha’il, Ha’il 2440, Kingdom of Saudi Arabia, Al Elaimi M. ,   Department of Basic Sciences, College of Preparatory Year, University of Ha’il, Ha’il 2440, Kingdom of Saudi Arabia, Hameed R. A. ,   Department of Basic Sciences, College of Preparatory Year, University of Ha’il, Ha’il 2440, Kingdom of Saudi Arabia, Ullah F. ,   Department of Physics, Hazara University Mansehra, Mansehra, 21300, Pakistan
Published: September 2022

Antibiotic resistance is concerned with public health and a serious threat in modern world. Pathogenic strains are rapidly developing resistance against antibiotics and limiting the treatment options. Nanostructured zinc oxide (ZnO) shows significant results when doped with silver (Ag), therefore used as an antibacterial agent. In this work, we synthesized pure and varying concentration of Ag-doped ZnO nanoplates through a one-step hydrothermal route. The structural, morphological, and optical properties of prepared nanostructures were comparatively studied. Furthermore, we have performed the ager-well assay, minimum inhibitory concentration study, and minimum bactericidal concentration study of synthesized nanoplates against five different bacterial strains including A. baumannii, P. aeruginosa, E. coli, K. pneumoniae, and S. aureus. The antimicrobial screening shows that Ag-doped ZnO nanoplates are more effective against all pathogenic strains as compared to pure ZnO, and therefore can be used in biomedical science.
Effect of 4A zeolite on adsorption and release properties of sodium alginate/chitosan microspheres to sodium valproate
Authors:   Institute of New Pesticide Innovation﹠Research, Qingdao Agricultural University， Qingdao,People's Republic of China, Chen W. Y , Jiao X. J. ,   Institute of New Pesticide Innovation﹠Research, Qingdao Agricultural University， Qingdao,People's Republic of China, Liu Y. F. ,   Institute of New Pesticide Innovation﹠Research, Qingdao Agricultural University， Qingdao,People's Republic of China, Liu J. X. ,   Institute of New Pesticide Innovation﹠Research, Qingdao Agricultural University， Qingdao,People's Republic of China, Zhang B. H. ,   Institute of New Pesticide Innovation﹠Research, Qingdao Agricultural University， Qingdao,People's Republic of China
Published: September 2022

4A zeolite/sodium alginate/chitosan microspheres (4A/SA/CS Ms) and sodium alginate/chitosan microspheres (SA/CS Ms) were prepared and its characterization were confirmed by the results of XRD, FTIR and SEM. Results showed that the addition of 4A zeolite can enlarge its particle size and is more conducive to balling. Adsorption properties of two microspheres toward sodium valproate (SV) were studied at different pH and temperature and it can be observed that the equilibrium adsorption capacity of 4A/SA/CS Ms for SV at pH = 7 was 8.1833 mg/g, compared with 4.9776 mg/g by SA/CS Ms, which reveal that 4A zeolite can increase the adsorption capacity. Cumulative release percentage reach to 42.69% in 48 hours by 4A/SA/CS@SV Ms at 25 ℃ and pH = 7 which demonstrated that 4A zeolite could improve the drug release performance. Overall, these results suggest that 4A/SA/CS Ms show a case to be used as promising drug carriers.
Glove Defect Detection Via YOLO V5
Authors: How Yong Chen , Ab. Nasir Ahmad Fakhri , Muhammad Khairul Fikri , P. P. Abdul Majeed Anwar , Mohd Razman Mohd Azraai , Zakaria Muhammad Aizzat
Published: September 2022

Malaysia is one of the biggest producers and exporters of gloves in the world. To meet and exceed the customer’s expectation, a predictive defect model is necessary to minimize the defect glove. There are three crucial parts to develop an effective defect glove detection model, which are data collection, model development and model evaluation. The data provided should be good quality, the algorithm for developing the model should reach high accuracy and high inference time due to the fast glove production line, and the developed model must compare to the other quality model to prove its robustness and effectiveness. This paper focuses on employing the YOLO V5 model for glove defect detection as well as investigating the efficiency of other several deep learning approaches. The dataset collected in this research was 493 images with three classes which are normal glove, tear glove and unstripped glove. To avoid overfitting due to the small amount of dataset, argumentation processes such as saturation, exposure and noise were applied to increase the dataset number to 1148 images. Data were then split to 70:20:10 for the training-validation-test ratio. The parameter setup was 100 epochs with 129 iterations. The YOLO V5 was compared with Scaled YOLO V4, Detectron2 and EfficientDet by the training time, model size, accuracy, and inference time. In conclusion, the best model was YOLO V5 because it reached the lowest training (0.259 hour) and inference time (0.0095 seconds), smallest model size (14418kb) and highest accuracy (mAP = 0.9951).
Pressure Based Control For A Variable Speed Diesel Engine Driven Pump Controller
Authors: Mohd Jamil Muhammad Arieffuddin , Mohd Romlay Fadhlur Rahman , Muhamad Khairul Fikri , Abdul Samat Shamsudin , Ishak Ismayuzri
Published: September 2022

Chemical cleaning is a process that utilizes chemical as a cleaning medium to remove unwanted contaminants. The chemical cleaning process may involve with the use of pump to circulate the chemical during cleaning process. The pump for the cleaning process can be driven by electrical or internal combustion engine. This paper presents the development of a variable speed diesel engine driven  pump controller for chemical cleaning application. The controller utilize proportional control method as the control scheme. The variable speed diesel engine driven pump system includes a diesel engine coupled with centifugal pump, a controller, pressure sensor, and battery powerpacks. All the components are mounted on a skid platform for the ease of use as a system. Proportional control method were used in order to get the critical gain parameter to compute PID parameter gains using Ziegler Nichols tuning method
Challenges of Ground Control System in Ensuring Safe Flights for Unmanned Aerial Vehicles
Authors: Mohammed Ameer , Ibrahim Bashir Garba , Momoh Muyideen Omuya , Ter Kumater Peter , Adetifa Abolanle Oluwatoyin , Oluwole Damilare Abdulbasit
Published: September 2022

Unmanned Aerial Systems (UAS) are considered as evolving technology due to the diversity and feasibility of their applications. Generally, UAS are controlled by a ground operator in a ground control station (GCS). GCS can be used for several remote applications for unmanned vehicles; however, for the purpose of this review, GCS applications would be limited to its application on Unmanned Aerial Vehicles (UAV). Such stations are made up of basic components consisting of commercial-off-the-shelf components and low-cost equipment depending on the sophistication of the UAV. This requires that as UAVs evolve, GCS are equally upgraded to meet with the technological feet. This paper discusses the challenges associated with GCS in ensuring safe operations of the UAV. Hence, a brief background of GCS, its architecture, applications, inherent challenges and the proposed solutions are presented.
Badminton Smashing Recognition through Video Performance by using Deep Learning
Authors: Yip Zi Ying , Mohd Khairuddin Ismail , Mohd Isa Wan Hasbullah , P. P. Abdul Majeed Anwar , Abdullah Muhammad Amirul , Mohd Razman Mohd Azraai
Published: September 2022

Nowadays, badminton become the hot trends sport in Malaysia due to the influence of Lee Zii Jia which is the Malaysian badminton player and he has been participate the men’s single badminton in Tokyo 2020 Olympic Game at the Musashino Forest Sports Plaza in Tokyo. Due to this reason, sport analysis become one major contribution in analysing and improving the performance of athlete. Hence, this project constructs a badminton smashing recognition through video performance by using the deep learning. The main purpose of this project is to evaluate the performance of the models in classifying the types of smashing in badminton. The models will be trained using Deep Learning models of ResNet-18, GoogleNet and VGG-16 and the best precision of badminton smashing accuracy were compared. In this project, we found that ResNet-18 has the best performance of accuracy of 97.51% and 98.86% on both training and testing datasets respectively by using the software Jupyter. On other hand, GoogleNet has the highest accuracy of 83.04% and 97.20% on both training and testing datasets respectively by using hardware Jetson Nano.
Analysis and Design of Control System for Desktop Size Concrete 3D Printer
Authors: Iqbal A. R. , Muhammad Khairul Fikri
Published: September 2022

Concrete, in construction, structural material consisting of a hard, chemically inert particulate substance, known as aggregate (usually sand and gravel), that is bonded together by cement and water. Concrete is the world's second-most-used substance after water, and it is also the most extensively used building material. 3D printer has become a prominent method of additive manufacturing with its rapid prototyping capabilities and is able to reduce the time and cost of any complex manufacturing process. This paper describes work the process of 3D design, analysis, manufacturing and testing of a concrete 3D printer to explore the plausibility and sustainability of concrete 3D printing to replace the conventional construction method. A desktop size concrete 3D printer concrete 3D printer with 0.5×0.5×0.5 m print volume is developed for lab testing, which utilizes computer-based control system to layer-by- layer construct physical objects is developed to study the usability of the printer as well as the feasibility of replacing the conventional construction method. The development of the 3D printer is divided into two parts, Part A: Mechanical and Part B: Control System. Concrete 3D printing technology is not widely known and is expensive to be deployed. Thus, greater research and development of the technology is required to evolve into a more mature study that is accessible to consumers. The project output envisions as to lay a foundation for extended studies and applications of 3D printed concrete in Malaysia
Automated Detection of Knee Cartilage Region in X-ray Image
Authors: Teo Jia Chern , Mohd Khairuddin Ismail , Mohd Razman Mohd Azraai , P. P. Abdul Majeed Anwar , Mohd Isa Wan Hasbullah
Published: September 2022

The prevalence of a symptomatic knee or osteoarthritis (OA) is approximately 9.6% in men and 18.0% in women over 60 years of age according to the OARSI 2016 report. Using early on-stage clinical qualitative assessments through means of X-ray scans, the cartilage health and degradation of an individual can be monitored through cartilage shape and surface over time. In this paper, we implement the application of transfer learning models such as InceptionV3, Xception and DenseNet201 for feature extraction of a rebalanced 1,000 knee X-ray images taken from Osteoarthritis Initiative (OAI) dataset with 5 classes graded 0–4 according to Kellgren-Lawrence grading split into a 70/15/15 training/validation/testing split. The features extracted are subsequently fed into machine learning classifiers, namely support vector machine (SVM). An average multiclass accuracy of 71.33% was achieved for hyperparameter fine-tuned DenseNet201-SVM model.
Regulation of financial supervision in the European Union
Authors:   Kozminski University, Głuchowski Jan , Górski Krzysztof Adam ,   Kozminski University
Published: September 2022

This contribution offers a broad theory on the regulation of the financial supervisory architecture in the European Union. It discusses the macro- and micro-prudential competences of the specialised agencies that are now ranging from direct supervision of individual financial institutions to the ability to impose market-wide restrictions on financial activities. The regulatory response to the financial crisis of 2007/08 centralised and strengthened the EU competences of monitoring financial markets and enforcing cooperation between the national competent authorities, especially in cross-border situations. It is however observed that – with some notable exceptions – the supervisory model in the European Union remains fragmented. Lack of direct supervisory powers – especially in the securities and payments markets – means that many international institutions remain without appropriate supervision. This results not only in weaker consumer protection and increased systemic risk, but also in jurisdictional arbitrage and, ultimately, damaged competitiveness of the European financial sector.
Tax not clear on what?
Authors:   University of Białystok, Poland, Etel Leonard
Published: September 2022

Property tax is the second, after VAT, most contested issue to administrative courts. The reason for such a situation is wrongly determined subject of tax. This paper presents basic weaknesses of the regulations regarding buildings, structures and land. These problems may be eliminated only by radical changes in the binding law. Without them, this tax will still cause difficulties in its practical implementation.
Practical experience and the significance of the settlement tax in Hungary
Authors:   Széchenyi István Egyetem, Hungary, Hulkó Gábor , Pardavi László ,   Széchenyi István Egyetem, Hungary
Published: September 2022

The study deals with the theoretical and practical issues of settlement taxes as a special type of local taxes. The settlement tax is a unique type of local tax introduced in 2015, which can be levied on anything that is not subject to any other public or local tax. Municipalities, therefore, have a relatively large margin of discretion in setting the settlement tax. Within the framework of the present research, the significance of this type of tax within the Hungarian municipalities was examined from both a regulatory-theoretical and a practical perspective. It can be concluded that while from a theoretical-regulatory point of view a workable model for the implementation of this type of tax has emerged, the fiscal significance of this tax and its practical application is less popular. This study evaluates and analyses the period since the introduction of the settlement tax in the Hungarian legal system.
Digital assets: Kazakhstan’s experience
Authors:   Caspian University, Republic of Kazakhstan, Moroz Svetlana Pavlovna
Published: September 2022

This article is devoted to the study of digital assets in the Republic of Kazakhstan. The purpose of the article is to explore Kazakhstan’s experience in the legal regulation of digital assets and to identify further areas for legislative improvements. It is noted that Kazakhstan’s legislation does not regulate digital money, but the term “digital asset” is used. It is spoken in detail about secured and unsecured digital assets, as well as the procedure for their issuance and circulation in the financial market. The article gives a detailed analysis of the norms of the RoK Laws “On Payments and Payment Systems”, and “On Informatization”. Much attention is given to the history of cryptocurrencies and the attempts of individual states to introduce their own electronic payment systems in digital currency. In this regard, the main provisions of the draft Model Law of the Commonwealth of Independent States “On Digital Financial Assets” are analysed and some comments are made on the establishment of a single regime for secured and unsecured digital assets and on the distinction between corporate (investment) and obligation (credit) digital assets. As a result of this study, the Author concludes that digital assets have now become widely used and for this reason states need to change their attitude towards them, that is stop ignoring them, and it is necessary to define their legal regime.
Development of budgetary rules in the Czech Republic
Authors:   Masaryk University, Czech Republic, Czudek Damian
Published: September 2022

At a time when more and more demands are made on public budgets, it is appropriate to evaluate the rules governing the institutes of budget management and consider strengthening the instruments that ensure efficient, economy and effective management of public funds. For this reason, the contribution is devoted to the analysis of the development of budgetary rules in the Czech Republic, especially to the analysis of breach of budgetary discipline, which is an important part of the financial management and control of public budgets. This article also follows the outputs of the Ministry of Finance project, co-financed by the he EEA and Norway grants 2014-2021, which is dedicated to strengthening public financial management and control.
11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease
Authors: Nowotny Hanna F , Braun Leah , Vogel Frederick , Bidlingmaier Martin , Reincke Martin , Tschaidse Lea , Auer Matthias K , Lottspeich Christian , Wudy Stefan A , Hartmann Michaela F , Hawley James , Adaway Joanne E , Keevil Brian , Schilbach Katharina , Reisch Nicole
Published: September 2022

Background

Symptoms of hyperandrogenism are common in patients with Cushing's disease (CD), yet they are not sufficiently explained by androgen concentrations. In this study, we analyzed the contribution of 11-oxygenated C19 steroids (11oxC19) to hyperandrogenemia in female patients with CD.

Methods

We assessed saliva day profiles in females with CD pre (n = 23) and post (n = 13) successful transsphenoidal surgery, 26 female controls, 5 females with CD treated with metyrapone and 5 treated with osilodrostat for cortisol, cortisone, androstenedione (A4), 11-hydroxyandrostenedione (11OHA4), testosterone (TS), 11-ketotestosterone (11KT), as well as metabolites of classic and 11-oxygenated androgens in 24-h urine. In addition, morning baseline levels of gonadotropins and estradiol, sex hormone-binding globulin, cortisol and dehydroepiandrosterone sulfate (DHEAS) in serum and adrenocorticotrophic hormone in plasma in patients and controls were investigated.

Results

Treatment-naïve females with CD showed a significantly elevated area under the curve of 11OHA4 and 11KT in saliva throughout the day compared to controls (11OHA4 mean rank difference (mrd) 18.13, P = 0.0002; 11KT mrd 17.42; P = 0.0005), whereas A4, TS and DHEAS were comparable to controls. Gonadotropin concentrations were normal in all patients with CD. After transsphenoidal surgery, 11oxC19 and their metabolites dropped significantly in saliva (11OHA4 P < 0.0001; 11KT P = 0.0010) and urine (11-oxo-androsterone P = 0.0011; 11-hydroxy-androsterone P < 0.0001), treatment with osilodrostat and metyrapone efficaciously blocked 11oxC19 synthesis.

Conclusion

Hyperandrogenemia in CD is predominantly caused by excess of 11oxC19 steroids.
Follicular and hormonal changes after estrous synchronization in bottlenose dolphins
Authors: Montano Gisele , Clough Pat , Schmitt Todd , Davis Michelle , Steinman Karen , O’Brien Justine , Robeck Todd
Published: September 2022

To gain more knowledge about the influence of hormone regulation on follicle development, ovarian ultrasounds were performed, and urinary hormone profiles were determined in ovulating and non-ovulating female bottlenose dolphins (n  = 15) following estrus synchronization with altrenogest. Ovarian ultrasounds were conducted daily, post-synchronization to describe follicular recruitment in relation to the endocrine profile. Follicle sizes were grouped into very small (VSM), small (SM), medium (MD) and large (LG). In ovulating females, two follicular waves were identified, and follicular deviation toward establishing a dominant follicle only occurred during the second wave. For non-ovulating females, only the first wave was observed. For all urinary hormones, the non-ovulating group presented significantly lower concentrations of follicle-stimulating hormone (uFSH), luteinizing hormone (uLH), estrone conjugates (uE1-C) and estriol (uE3) but similar progestagen and cortisol concentrations compared to the ovulating group. Concentrations of uE1-C and uE3 and the numbers of MD and LG follicles significantly (P < 0.05) increased, while uFSH concentrations significantly (P < 0.05) decreased as ovulation approached. Urinary LH significantly increased concurrently with increasing numbers of LG follicles and decreasing numbers of SM follicles. The characterization of follicular development and its relationship with hormone assessment complements our understanding of follicular recruitment post-synchronization in bottlenose dolphins and provides new information concerning differences between ovulating and non-ovulating females in response to an estrous synchronization protocol.

Lay summary

Many species of fresh and saltwater dolphins and porpoises are facing increasing pressure for food and habitats due to human activities. One of the primary aspects that can be affected by such activities is reproduction. The bottlenose dolphin has been successfully bred in zoos and aquariums for at least 70 years, and they can be trained for several voluntary behaviors that enable medical examinations. Therefore, they represent a unique resource for research and understanding of normal dolphin reproduction. In this research, voluntary ultrasound exams and urine samples from 15 female dolphins were used to describe changes in their ovaries. The resulting descriptions and comparisons provide insight into the unique ovarian physiology of bottlenose dolphins and into the differences between animals after treatment. This information adds to the body of knowledge which one day may be used for developing advanced reproductive techniques to help preserve endangered species of dolphins.
Sustainability Agreements and Social Norms
Authors: Inderst Roman , Rhiel Felix , Thomas Stefan
Published: September 2022

Spurred by recent publications of National Competition Agencies, there is an ongoing debate on whether and, if so, how competition law and its enforcement shall give due consideration to concerns of sustainability, notably environmental sustainability. With respect to horizontal agreements, we define circumstances where sustainability concerns may indeed warrant a somewhat modified approach for the assessment of consumer welfare implications of a market related measure. We posit a feedback-effect on the willingness-to-pay for more sustainable products when a horizontal agreement leads other consumers to change their behavior. The underlying reason for this stems from the non-use value associated with sustainability and from its relation to social norms. In such scenarios, there can be a first-mover disadvantage for a firm who would unilaterally introduce a more sustainable product, which may justify horizontal cooperation. More generally, we argue that the construction of counterfactuals, in particular over a longer time horizon, may prove particularly challenging in a competitive assessment of sustainability claims. We also document the feedback effect arising from other consumers’ behavior with data that the Dutch Competition Authority gathered for its “Chicken of Tomorrow” case.
Rückstellungen für kartellrechtliche Risiken nach HGB und IFRS
Authors: Hennrichs Joachim , Pöschke Moritz
Published: September 2022

Kartellrechtliche Risiken spielen in der Wirtschaftspraxis eine immer größere Rolle. Die Bildung und Auflösung entsprechender Rückstellungen in den Abschlüssen der betroffenen Unternehmen kann erhebliche Ergebniseffekte haben und damit auch die Ausschüttungsfähigkeit (Dividendenpolitik) betreffen. Im April 2019 bildete etwa BMW ertragswirksam eine Rückstellung von 1,4 Mrd. € für von der EU-Kommission vermutete illegale Kartellabsprachen. Der folgende Beitrag vermittelt einen systematischen Überblick über den gesamten Themenkomplex – und zwar mit Blick auf Abschlüsse nach HGB wie IFRS. Nach einer Darstellung der einschlägigen Risiken, für die aus Sicht der betroffenen Unternehmen eine Rückstellungsbildung in Betracht kommt, werden die Voraussetzungen für die Bildung und Bewertung von Rückstellungen eingehend untersucht.
Will sustainability and environmental considerations be the next big hit for shaping the application of Article 102 TFEU?
Authors: Lindenberg Helen
Published: September 2022

The German Federal Cartel Office’s (FCO) proceedings against Facebook have made big waves. The FCO used antitrust instruments, but based its action on a violation of data protection regulations. This action could serve as a blueprint for the violation of other non-competitive regulations, such as the violation of sustainability and environmental goals. This paper explores whether and how specifically Article 102 TFEU can serve in implementing sustainability and environmental considerations.
Optimizing Antibiotic Treatment of Skin Infections in Pediatric Emergency and Urgent Care Centers
Authors: Wiltrakis Susan May , Jaggi Preeti , Lu Lydia , Jain Shabnam
Published: September 2022

OBJECTIVES

The objective was to optimize antibiotic choice and duration for uncomplicated skin/soft tissue infections (SSTIs) discharged from pediatric emergency departments (EDs) and urgent cares (UCs).

METHODS

Pediatric patients aged 0 to 18 years discharged from 3 pediatric EDs and 8 UCs with a diagnosis of uncomplicated SSTIs were included. Optimal treatment was defined as 5 days of cephalexin for nonpurulent SSTIs and 7 days of clindamycin or trimethoprim/sulfamethoxazole for purulent SSTIs. Exclusion criteria included erysipelas, folliculitis, felon, impetigo, lymphangitis, paronychia, perianal abscess, phlegmon, preseptal or orbital cellulitis, and cephalosporin allergy. Baseline data were collected from January 2018 to June 2019. Quality improvement (QI) interventions began July 2019 with a revised SSTI guideline, discharge order set, and maintenance of certification (MOC) QI project. MOC participants received 3 education sessions, monthly group feedback, and individual scorecards. Balancing measures included return visits within 10 days requiring escalation of care. Data were monitored through March 2021.

RESULTS

In total, 9306 SSTIs were included. The MOC QI project included 50 ED and UC physicians (27% of eligible physicians). For purulent SSTI, optimal antibiotic choice, plus duration, increased from a baseline median of 28% to 64%. For nonpurulent SSTI, optimal antibiotic choice, plus duration, increased from a median of 2% to 43%. MOC participants had greater improvement than non-MOC providers (P < .010). Return visits did not significantly change pre- to postintervention, remaining <2%.

CONCLUSIONS

We improved optimal choice and reduced duration of antibiotic treatment of outpatient SSTIs. MOC participation was associated with greater improvement and was sustained after the intervention period.
A 14-Year-Old Female With Chest Mass, Shortness of Breath, and Hypertension
Authors: Kirkman Kelsey , Prudowsky Zachary D. , Shah Shweta , Demmler Harrison Gail , Rao Seema , Cohen Adam
Published: September 2022

BACKGROUND

A previously healthy 14-year-old girl was evaluated in the emergency department (ED) with 2 months of shortness of breath and fatigue.

METHODS

She initially presented to her primary pediatrician, where a complete blood count was only significant for mild anemia, thyroid function tests were normal, and a chest x-ray revealed a chest mass. This prompted her primary pediatrician to order a computed tomography scan and refer to the ED.

RESULTS

Her computed tomography scan confirmed a mediastinal mass versus necrotic lymphadenopathy. Her initial physical exam was unremarkable, except for hypertension. From the ED, she was admitted to the pediatric hospital medicine service. Infectious disease, oncology, and nephrology services were consulted to guide diagnostic evaluation.

CONCLUSIONS

Eventually, during her hospitalization, further history and workup led to a definitive diagnosis.
Tactics of diagnostics and treatment of dysplasia of mammary glands and hysteromyoma at women of perimenopause age
Authors:   I. Horbachevsky Ternopil State Medical University of the Ministry of health of Ukraine, Kruk O.Yu.
Published: September 2022

The objective: development and deployment of tactics of diagnostics and treatment of dysplasia of mammary glands in combination with hysteromyoma at women of perimenopause age Materials and methods. Complex clinical-laboratory, ehografical and morphological examination 93 women of perimenopause age with the combined pathology – benign dysplasia of mammary glands and hysteromyoma was conducted. Results. Should be noticed efficiency of the complex developed by us that at women with the combined pathology it was succeeded to carry out to 43.4% of cases prophylaxis of advance and a recedives of dysplasia of mammary glands and to 36.7% – hysteromyomas. The obtained data, in our opinion, convincingly testify that complex conservative treatment of the women suffering from illnesses of mammary glands in combination with hysteromyoma, is preventive action concerning advance and recedives of the combined pathology at this category of patients. Conclusion. The results received by us grant to us the right to recommend an offered complex in practical health care. Key words: dysplasia of mammary glands, hysteromyoma, diagnostics, treatment, perimenopause age.
Psychological and medical aspects of pregnancy and birth in single women
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Benyuk V.O. , Kurochka V.V. ,   Bogomolets National Medical University, Kyiv, Ukraine, Koroluk N.P. ,   Bogomolets National Medical University, Kyiv, Ukraine,, Oleshko F.V. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: September 2022

The article presents data on the results of clinical and statistical analysis, estimation of the pregnancy course and labor in single and married women. Studies have shown that single women are at high risk of developing obstetric and perinatal complications. The age of single women exceeded 6 years; among them housewives were 5 times more often; the gynecological anamnesis of single women is three times more complicated and somatic anamnesis is twice as complicated. Marital status and partner support during pregnancy, labor and postpartum can improve obstetric and perinatal birth outcomes, as well as the clinical course of the postpartum period. Inadequate family structure, psychological and social factors in single women have a negative impact on the course of pregnancy and childbirth. Key words: pregnancy and delivery, single women, perinatal complications.
New approaches in the treatment of cervical erosion and vaginal atrophy
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Podolsky Vl.V , Podolsky V.V ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv
Published: September 2022

The therapeutic use of various materials has long been known in medical practice. The use of polymers in dental surgery, eye surgery, heart surgery and other areas today is widespread in most countries. Substances that interact with human cells are called biomaterials. However, many issues of the interaction between human cells and synthesized materials remain unresolved, for example, such as compatibility and degradation in the case of prosthetics. The development of combined materials containing human proteins or cells and complex polymers is a promising industry in the development of medicine. The extracellular matrix (ECM) is an auxiliary substance for each cell of the human body, contains proteins and macromolecules. Substances derived from ECM are now widely used as biomaterials, such as collagen and hyaluronic acid. A large number of studies on the effect of hyaluronic acid on the human body, allowed us to determine its main properties, due to which hyaluronic acid is widely used in the medical, pharmaceutical and cosmetic industries, namely, for its high bioavailability, degradability, and lack of response of the immune system to this compound, as well as for its viscoelasticity. Such properties of hyaluronic acid provide the possibility of its use in obstetric and gynecological practice. Vaginal suppositories with hyaluronic acid and medicinal plants are becoming popular because they are safe and effective, which doctors and patients pay attention to. The preparations Gial-Eroz and Gial-Meno, which are presented in the form of suppositories, are the optimal dosage form for intravaginal use. The use of Gial-Eroz and Gial-Meno drugs, which have various mechanisms for restoring the vaginal mucosa, can be an effective part of complex therapy in women with cervical erosion and atrophic vaginitis. Key words: cervical erosion, vaginal atrophy, women, hyaluronic acid, vitamins, postmenopausal period, Gial-Eroz, Gial-Meno.
The role of mixed infection in pathological processes of the epithelium of the genitals with atypia of cells of unclear genesis in women with infertility
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kiev, Kaminskiy V.V. , Sumenko V.V. ,   Shupyk National Medical Academy of Postgraduate Education, Kiev, Bondaruk O.Y. ,   Shupyk National Medical Academy of Postgraduate Education, Kiev, Gak I.O. ,   USIR Shupyk National Medical Academy of Postgraduate Education, Kiev,   Kyiv City Center for Reproductive and Perinatal Medicine
Published: September 2022

The objective: In purpose to study the biocenosis and infectious agents of the urogenital tract in women with infertility combined with pathological processes of epithelium of the genitals with atypia of cells of unclear genesis. Matirials and methods. 148 women with infertility and pathological processes of epithelium of the genitals with atypia of cells of unclear genesis were examined. The control group included 80 women with infertil. All patients underwent cytological, bacterioscopic, bacteriological examination and polymerase chain reaction to diagnose urogenital tract infections. Results. Dysbiosis of the microflora of the vagina was observed in women with infertility and the presence of pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis. Sexually transmitted infections are reported in 60.1% of patients. In the structure of sexually transmitted infections, prevailed mixed infections (mycoplasmosis associated with ureaplasmosis – 24.3%, and chlamydia with ureaplasmosis – 4.7%) and mono-infections (ureaplasmosis – 10.8%, mycoplasmosis – 13.5%, chlamydia – 4.7%). In 21.3% of cases was detected an association of human papillomavirus with sexually transmitted infections and vaginal dysbiosis. In most cases were observed highly oncogenic types of human papilloma virus, in particular, 18 type and similar types – 19.6%, 16 type and similar types – 8.8% and 45 type and similar types – 15.5%. Conclusion. Due to the prevalence of fungi of the genus Candida, aerobic and anaerobic flora there is a violation of vaginal biocenosis in patients with infertility combined with pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis. Among the sexually transmitted infections are the most common mixed infection of M. genitalium + U. urealyticum and M. hominis + U. urealyticum, as well as mono-infection with urea-micoplasmosis and chlamydia. HPV is 6.2 times more higher than in the comparison group. Highly oncogenic types of HPV were detected in the structure of virus types with a significant difference, in particular, 18 type and similar types, 16 types and similar types. 45 type was determined only in patients with infertility combined with pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis. Key words: pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis (AGC-NOS); infertility; biocenosis of vagina, sexually transmitted infections; human papilloma virus.
The first experience in Ukraine of total replacement of a diaphragm defect (with its aplasia) by a muscle autograft in a newborn child
Authors:   Center for Neonatal Surgery for Congenital Malformations and Rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Sliеpov O.K. , Ponomarenko O.P. ,   Center for Neonatal Surgery for Congenital Malformations and Rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Znak К.L. ,   Center for Neonatal Surgery for Congenital Malformations and Rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Gladyshko O.P. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Golopapa G.V. ,   Center for Neonatal Surgery for Congenital Malformations and Rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv
Published: September 2022

Congenital diaphragmatic hernias, in newborns, with large defect of the diaphragm, are an extreme risk group and characterized by high mortality. We present our own experience of successful surgical treatment of a newborn with aplasia of the left half of the diaphragm. The child was born in the State Institution «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova National Academy of Medical Sciences of Ukraine» with a prenatal diagnosis. After preoperative stabilization, for the first time in Ukraine, the left half of the diaphragm was completely replaced with a split muscle flap from the anterior abdominal wall. The child survived after the operation, his physical development corresponds to age. During the 3-year follow-up, there are no signs of recurrence. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Keywords: congenital diaphragmatic hernia, diaphragmatic aplasia, surgical correction, flap of the muscles of the anterior abdominal wall, newborn baby.