bluuebunny/crossref_metadata_2025 huggingface dataset:
A toxina botulínica nos tratamentos estéticos faciais para a feminização - Relato de Caso
Authors: Machado Costa Cieila Caroline , Monteiro Andrea Guion , Albergaria-Barbosa José Ricardo de , Silva Luiz Carlos Foletto da , Rizzatti Barbosa Célia Marisa
Published: March 2022

Introdução: Os recursos da harmonização facial para suavizar ou evidenciar traços tem sido buscado por  homens e mulheres, e, neste contexto, insere-se a feminização, um tratamento para acentuar a definição feminina da face, que ora envolve aspectos forenses, além dos éticos. Para tal, tem-se utilizado a TBA , intervenção minimamente invasiva, no sentido de  delinear movimentos expressivos de músculos da face. Os maiores desafios no uso da toxina botulínica do tipo A (TBA) estão relacionados às expectativas do paciente e à escolha de técnicas adequadas, e associações. A força e extensão da musculatura determinam a dose a ser utilizada no tratamento. Objetivo: O objetivo deste trabalho consiste em apresentar um relato de caso com o uso da TBA (Allergan, BOTOX®) como recurso para feminização facial, como uma alternativa na busca de traços naturais da face e elevação da auto estima. Relato de Caso: Paciente do gênero masculino, com 43 anos de idade, apresentava músculos da expressão facial de alta tonicidade, com movimentos e expressões típicos da constituição física masculina. Instituiu-se a intervenção com de toxina botulínica do tipo A, nos pontos musculares estratégicos, que culminaram no delineamento feminino da face. Conclusões: O tratamento com injeção de TBA, além de ter elevado grau de satisfação do paciente, também apresentou baixo índice de complicações ou efeitos colaterais, além de admitir-se como um complemento importante no contexto de visagismo do paciente.
Chronic intestinal pseudo-obstruction: a case report with review of the literature and practical guidance for the clinician
Authors: De Meulder S , Vanuytsel T
Published: March 2022

Chronic Intestinal Pseudo-obstruction (CIPO) is a rare but debilitating and severe form of gastrointestinal dysmotility. The diagnosis is often made very late in the disease course due to its rarity and complexity. Treatment is mainly supportive, as there is no definitive cure. Pharmacologic therapy comprises prokinetics, antibiotics for bacterial overgrowth and pain management. Pain can also be alleviated with intestinal decompression in selected cases. Beside the pharmacologic therapy, nutrition and fluid replacement play a key role. Rarely, intestinal transplantation is necessary in patients with CIPO and intestinal failure. In this review, we describe an advanced CIPO case and provide an update of the clinical and diagnostic features and current management strategies. The goal of our review is to raise awareness around CIPO and to give practical guidance for the clinician.
Calibration of Line Impedance Stabilization Network / Artificial Mains Network in accordance with CISPR 16-1-2 Ed 2.1 2017-11
Authors:   Standards and Calibration Laboratory, Lai H.W. ,   The Government of the Hong Kong Special  Administrative Region, Tsui C.M. , Ma C.K. , Yang S.L
Published: March 2022

This paper describes a measurement procedure developed by the Standards and Calibration Laboratory (SCL) for measuring the parameters of single phase 50 Ω/50 μH + 5 Ω V-network type Line Impedance Stabilization Networks (LISN) or Artificial Mains Networks (AMN) specified in the International Standard CISPR 16-1-2, which are the impedance at the EUT port, the isolation between the power port and the receiver port, and the voltage division factor between the EUT port and the receiver port. The corresponding measurement models and evaluation of measurement uncertainties are presented. Characterization method of in-house developed adapters for BS1363 type plug and socket is also presented.
Measurement of Voltage Transformer Errors using a Self-calibrating Multi-ratio Capacitive Divider System
Authors:   National Measurement Institute Australia, Emms Frederick
Published: March 2022

A new portable voltage transformer (VT) calibration system has been developed, based on an existing fixed laboratory system. The existing system is based on a high voltage compressed gas capacitor in the upper arm of a voltage divider, and a range of precision air capacitors in the lower arm, with the errors being balanced via the use of inductive voltage dividers. The new system utilises the same high voltage compressed gas capacitor in the upper arm but in the lower arm uses small, class 1, multi-layer ceramic capacitors. Instead of balancing the system with inductive voltage dividers, a direct measurement of the VT errors is made with the use of an integrating amplifier and two digital multimeters (DMMs). One DMM measures the secondary voltage and the other measures the relative phase and amplitude of the error voltage from an integrating amplifier. Using a VT with the nominal ratio of 10:1, and the ability of switching several of the lower arm ceramic capacitors into the upper arm, and then following a sequence of measurements, all the relative capacitance values can be calculated using a mathematical build-up process. The new portable VT calibration system has achieved a typical measurement uncertainty for voltage error and phase displacement of better than 0.003% and 0.003 crad respectively. It can test VTs with applied primary voltages from 30 V to 220 kV, and secondary voltages from 10 V to 300 V, with the ratio settings of the capacitive divider in the range of 0.1 to 2200. The system has been optimised for operating at 50 Hz and 60 Hz, but theoretically it could be used for higher frequencies.
Measurement Information Infrastructure (MII) Projects and Outlook
Authors: Kuster Mark
Published: March 2022

Have you heard of digital calibration certificates? Digital metrology? The digital quality infrastructure? The European Metrology Cloud? These globally scattered initiatives all seek to upgrade our industry from Metrology 2.5 to Metrology 4.0 by automating our remaining manual systems via networked intercommunication. Laboratories have long since automated many of their test and measurement processes, but the global quality infrastructure remains mired in paper and pdf documents that a) require subject-matter experts to interpret, and b) omit information that would have value if automatically put to use. NCSLI’s own initiative, the Measurement Information Infrastructure (MII), envisions a set of normative standards that define data structures, taxonomies, service protocols and security for locating, communicating and sharing measurement information seamlessly among our computing systems with little to no manual intervention. In this panel session, the NCSLI MII & Automation Committee will present its MII Vision, progress and outlook and describe some of the ongoing efforts. An open discussion and Q&A session will follow so that you may understand how an MII might affect your business and value stream.
Coletânea saúde na Amazônia: ensino e perspectivas
Authors: Feitosa Fabio Biasotto , Delani Daniel , Farias Edson dos Santos
Published: March 2022

É uma satisfação apresentar a “Coletânea Saúde na Amazônia: Ensino e Perspectivas – 2022”, que no formato de e-book traz reflexões sobre as práticas de cuidado, ensino e formação em saúde. É fruto do trabalho contínuo de investigação de um grupo de docentes e discentes preocupados com as práticas de saúde e a formação em saúde em Rondônia.
Combining of Mie-Raman and fluorescence observations: a step forward in aerosol classification with lidar technology
Authors: Veselovskii Igor , Hu Qiaoyun , Goloub Philippe , Podvin Thierry , Barchunov Boris , Korenskii Mikhail
Published: March 2022

Abstract. The paper presents an innovative approach to reveal variability of aerosol type at high spatio-temporal resolution, by combining fluorescence and Mie-Raman lidar observations. The multi-wavelength Mie-Raman lidar system in operation at the ATOLL platform (ATmospheric Observatory of liLLe), Laboratoire d’Optique Atmosphérique, University of Lille, includes, since 2019, a wideband fluorescence channel allowing the derivation of the fluorescence backscattering coefficient βF. The fluorescence capacity GF, which is the ratio of βF to the aerosol backscattering coefficient, is an intensive particle’s property, strongly changing with aerosol type, thus providing a relevant basis for aerosol classification. In this first single version of the algorithm, only two intensive properties are used for classification: the particle depolarization ratio at 532 nm, and the fluorescence capacity, GF. We applied our new classification approach to ATOLL high performance lidar data obtained during 2020–2021 period, which includes strong smoke, dust and pollen episodes. It is demonstrated that separation of the main particle’s types and their mixtures can be performed with height resolution about 60 m and temporal resolution better than 10 minutes for the current lidar configuration.
Spatial heterogeneity in rain-bearing winds, seasonality and rainfall variability in southern Africa's winter rainfall zone
Authors: Conradie Willem Stefaan , Wolski Piotr , Hewitson Bruce Charles
Published: March 2022

Abstract. A renewed focus on southern Africa's winter rainfall zone (WRZ) following the Day Zero drought and water crisis has not shed much light on the spatial patterns of its rainfall variability and climatological seasonality. However, such understanding remains essential in studying past and potential future climate changes. Using a dense station network covering the region encompassing the WRZ, we study spatial heterogeneity in rainfall seasonality and temporal variability. These spatial patterns are compared to those of rainfall occurring under each ERA5 synoptic-scale wind direction sector. A well-defined “true” WRZ is identified with strong spatial coherence between temporal variability and seasonality not previously reported. The true WRZ is composed of a core and periphery beyond which lies a transition zone to the surrounding year-round rainfall zone (YRZ) and late summer rainfall zone. In places, this transition is highly complex, including where the YRZ extends much further westward along the southern mountains than has previously been reported. The core receives around 80 % of its rainfall with westerly or north-westerly flow compared to only 30 % in the south-western YRZ incursion, where below-average rainfall occurs on days with (usually pre-frontal) north-westerly winds. This spatial pattern corresponds closely to those of rainfall seasonality and temporal variability. Rainfall time series of the core and surroundings are very weakly correlated (R2<0.1), also in the winter half-year, implying that the YRZ is not simply the superposition of summer and winter rainfall zones. In addition to rain-bearing winds, latitude and annual rain day climatology appear to influence the spatial structure of rainfall variability but have little effect on seasonality. Mean annual rainfall in the true WRZ exhibits little association with the identified patterns of seasonality and rainfall variability despite the driest core WRZ stations being an order of magnitude drier than the wettest stations. This is consistent with the general pattern of near homogeneity within the true WRZ, in contrast to steep and complex spatial change outside it.
Spatial heterogeneity of 2015–2017 drought intensity in South Africa's winter rainfall zone
Authors: Conradie​​​​​​​ Willem Stefaan , Wolski Piotr , Hewitson Bruce Charles
Published: March 2022

Abstract. The 2014–2018 drought over South Africa's winter rainfall zone (WRZ) created a critical water crisis which highlighted the region's drought and climate change vulnerability. Consequently, it is imperative to better understand the climatic characteristics of the drought in order to inform regional adaptation to projected climate change. In this paper we investigate the spatio-temporal patterns of drought intensity and the recent rainfall trends, focusing on assessing the consistency of the prevailing conceptual model of drought drivers with observed patterns. For this we use the new spatial subdivision for the region encompassing the WRZ introduced in our companion paper (Conradie et al., 2022). Compared to previous droughts since 1979, the 2014–2018 drought in the WRZ core was characterised by a markedly lower frequency of very wet days (exceeding the climatological 99.5th percentile daily rainfall – including dry days) and of wet months (SPI1>0.5), a sub-seasonal attribute not previously reported. There was considerable variability in the spatial footprint of the drought. Short-term drought began in the south-western core WRZ in spring 2014. The peak intensity gradually spread north-eastward, although a spatially near-uniform peak is seen during mid-2017. The overall drought intensity for the 2015–2017 period transitions radially from most severe in the WRZ core to least severe in the surroundings. During 2014 and 2015, the drought was most severe at those stations receiving the largest proportion of their rainfall from westerly and north-westerly winds; by 2018, those stations receiving the most rain from the south and south-east were most severely impacted. This indicates an evolving set of dynamic drivers associated with distinct rain-bearing synoptic flows. No evidence is found to support the suggestion that the drought was more severe in the mountain catchments of Cape Town's major supply reservoirs than elsewhere in the core nor that rain day frequency trends since 1979 are more negative in this subdomain. Rainfall and rain day trend rates also exhibit some connections to the spatial seasonality structure of the WRZ, although this is weaker than for drought intensity. Caution should be applied in assessing South African rain day trends given their high sensitivity to observed data shortcomings. Our findings suggest an important role for zonally asymmetric dynamics in the region's drought evolution. This analysis demonstrates the utility of the spatial subdivisions proposed in the companion paper by highlighting spatial structure in drought intensity evolution linked to rainfall dynamics.
A global dataset of spatiotemporally seamless daily mean land surface temperatures: generation, validation, and analysis
Authors: Hong Falu , Zhan Wenfeng , Göttsche Frank-M. , Liu Zihan , Dong Pan , Fu Huyan , Huang Fan , Zhang Xiaodong
Published: March 2022

Abstract. Daily mean land surface temperatures (LSTs) acquired from polar-orbiters are crucial for various applications such as global and regional climate change analysis. However, thermal sensors from polar-orbiters can only sample the surface effectively with very limited times per day under cloud-free conditions. These limitations have produced a systematic sampling bias (ΔTsb) on the daily mean LST (Tdm) estimated with the traditional method, which uses the averages of clear-sky LST observations directly as the Tdm. Several methods have been proposed for the estimation of the Tdm, yet they become less capable of generating spatiotemporally seamless Tdm across the globe. Based on MODIS and reanalysis data, here we proposed an improved annual and diurnal temperature cycle-based framework (termed the IADTC framework) to generate global spatiotemporally seamless Tdm products ranging from 2003 to 2019 (named as the GADTC products). The validations show that the IADTC framework reduces the systematic ΔTsb significantly. When validated only with in situ data, the assessments show that the mean absolute errors (MAEs) of the IADTC framework are 1.4 K and 1.1 K for SURFRAD and FLUXNET data, respectively; and the mean biases are both close to zero. Direct comparisons between the GADTC products and in situ measurements indicate that the MAEs are 2.2 K and 3.1 K for the SURFRAD and FLUXNET datasets, respectively; and the mean biases are −1.6 K and −1.5 K for these two datasets, respectively. By taking the GADTC products as references, further analysis reveals that the Tdm estimated with the traditional averaging method yields a positive systematic ΔTsb of greater than 2.0 K in low- and mid-latitude regions while of a relatively small value in high-latitude regions. Although the global mean LST trend (2003 to 2019) calculated with the traditional method and the IADTC framework is relatively close (both between 0.025 to 0.029 K/year), regional discrepancies in LST trend does occur – the pixel-based MAE in LST trend between these two methods reaches 0.012 K/year. We consider the IADTC framework can guide the further optimization of Tdm estimation across the globe; and the generated GADTC products should be valuable in various applications such as global and regional warming analysis. The GADTC products are freely available at https://doi.org/10.5281/zenodo.6287052 (Hong et al., 2022).
La recepción de la definición de la música de san Agustín (Mus.1.2.2) en la obra y el pensamiento de san Isidoro de Sevilla
Authors: Diago Jiménez José María
Published: March 2022

La famosa definición de la música de san Agustín (Mus.1.2.2) tuvo una notable influencia posterior, siendo recogida por grandes autores como san Isidoro, quien define la música de manera parecida en varios lugares de su obra. El objetivo de este artículo es localizar y analizar estas definiciones isidorianas para delimitar su significado y su alcance dentro del pensamiento musical del obispo hispalense, así como las posibles fuentes utilizadas por san Isidoro para su elaboración.
López Alós, J. (2021): El intelectual plebeyo. Vocación y resistencia del pensar alegre, Madrid: Taugenit, 169 pp.
Authors: Medina-Vicent Maria
Published: March 2022

El intelectual plebeyo. Vocación y resistencia del pensar alegre es la continuación del trabajo que Javier López Alós sintetizó en Crítica de la razón precaria. La vida intelectual ante la obligación de lo extraordinario (2019). En esta nueva obra el autor focaliza en la reflexión sobre la figura del intelectual en nuestros días, destacando la perplejidad y el malestar como dos bases presentes en las trayectorias tanto de los investigadores consagrados, como de los más jóvenes. A través del concepto del “intelectual plebeyo” proyecta una reivindicación, una articulación del malestar que explora el potencial movilizador de la conciencia de desigualdad e injusticia del intelectual. El concepto de vocación, apunta López Alós, ha sido modulado para convertirse en una herramienta para la (auto)explotación y la servidumbre voluntaria. Frente a esto, su propuesta trata de centrarse en una práctica intelectual alternativa que supere la ideología neoliberal, por lo que el concepto “intelectual plebeyo” pretende politizar la posición precaria de gran parte de las personas que se dedican al trabajo intelectual. Así, “plebeyo” contiene un gran potencial movilizador, una conciencia de la desigualdad y la injusticia, así como una toma de postura ante estas.
A Comperative Study of Instagram Pages of Two Leading Turkish Museums: Topkapı Museum and Sakıp Sabancı Museum
Authors: ÇALIŞ Deniz
Published: March 2022

As the competition between the museums increase, tools like digital marketing are used to attract the stakeholders and increase museum attendance. By their nature, museums cannot be managed like regular consumer or industrial brands but there are areas where strategic moves can be made such as social communication. An important tool in this area is the social media where different means exist including Facebook, Instagram, Twitter. Museums thrive to attract visitors and stay close to other stakeholders using social media. Playing a major role in tourism markets as well as cultural and educational areas, museums follow the developments in social media and adapt to changing environments. Different methods exist for the classification of museums and for this study institutional classification of museums, namely State versus Private museums were considered and compared. In Turkey, as Topkapı Museum is one of the most visited museums among state museums, whereas Sakıp Sabancı Museum is among the most visited private ones, Instagram pages of these museums were taken into consideration. This study analyzes @topkapi_sarayi and @sakipsabancimuzesi Instagram pages, compares them in terms of number of followers, posts, topics, views/likes, comments and other content. The analysis is made for the whole year 2021 coverage of each page. Content analysis technique has been applied as the research technique for the study. The data has been analysed and recorded between January 03, 2022 and January 20, 2022. As of the end of the recording period, Sakıp Sabancı Museum has approximately 196.000 followers versus Topkapı Museum has approximately 37.100 followers. The results indicate that Sakıp Sabancı Museum is much more active in terms of number of posts (337 versus 68 posts) and variety of topics shared (24 versus 8). Thus the result is reflected in the total number of Views/Likes/Comments; that is 570.855 Views/Likes and 2872 Comments for Sakıp Sabancı Museum and 137.052 Views/Likes and 674 Comments for Topkapı Museum. The study also points out some suggestions to improve Instagram Page quality, content and attract new followers for the museums. Keywords: Museum, Social media, Instagram, @topkapi_sarayi, @sakipsabancimuzesi
Türkiye’de Eğitim Yönetiminin Amaç, Kapsam ve Yöntem Açısından İncelenmesi
Authors: Korkmaz Hacı Ali
Published: March 2022

The main function of education management is to ensure the functionality of education as a whole in a systematic way. Education management is a management mechanism responsible for the healthy functioning and supervision of educational institutions in harmony. Educational institutions need educational management in order to ensure the sociocultural richness of society and create a civilized youth by following the requirements of the era. Educational institutions also need a holistic planning consisting of a uniform and on-site unity of goals, scope and methods in order to systematically create the function expected of them. In order for this planning to be carried out in a functional and functional way, it is also necessary to create education management in an inclusive way. Key words: Education, Educational Institutions, Educational Administration
Association between depression and HbA1c levels in the elderly population with type 2 diabetes mellitus during COVID-19 pandemic
Authors: Zahra Zulfa , Ramadhani Cut T. , Mamfaluti Teuku , Pamungkas Subhan R. , Firdausa Sarah
Published: March 2022

Diabetes mellitus is a chronic progressive disease affecting the metabolic hormonal system and its prevalence in the elderly population is high. Depression is one of the psychiatric disorders in diabetic patients in particular during the coronavirus disease 2019 (COVID-19) pandemic. People with depression are more susceptible to leading an unhealthy lifestyle; therefore, depression and diabetes have a negative influence on life quality and aggravate complications and symptoms. The aim of this study was to determine the association between depression and hemoglobin A1c (HbA1c) levels in elderly with type 2 diabetes mellitus patients. A cross-sectional study was conducted where a total of 42 diabetic patients from the Puskesmas Belakang Padang, Batam of Indonesia was recruited. The HbA1c level, the main determinant of optimum glycemic control, was measured using ion-exchange high-performance liquid chromatography while the level of depression was assessed using Geriatric Depression Scale-15 (GDS-15). The association between depression and HbA1c levels was analyzed using the chi-squared test. Our study found that that 69% of the elderly with diabetes experienced a depression, classified as mild (40.5%), moderate (21.4%) and severe (7.1%). There were 61.9% of the subjects had poor HbA1c control. Our data suggested that the depression level was associated with HbA1c (p=0.002). In conclusion, there is a significant association between depression and HbA1c levels in the elderly with type 2 diabetes mellitus.
CIRCULATION OF PARAMIXOVIRAL INFECTION AMONG DECORATIVE PIGEONS OF SOUTH UKRAINE
Authors: Bogach N.V. , Selishcheva N.V. , Lizogub L.Yu. , Bogach D.N.
Published: March 2022

The article presents information on the results of monitoring regarding paramyxovirus diseases of fancy pigeons in the South Ukraine. Seropositivity to the PMV-1 virus was stated in the blood of fancy pigeons and their young (average antibody titer 3.2 log2 and 9.7 log2, respectively), while clinical signs of the disease were not ob-served in all birds, the infection being manifested in a subclinical form.
EFFECT OF THE PREPARATION «PROSTIMUL» ON IMMUNE STATUS, PRODUCTIVITY AND SAFETY OF RETARDED IN GROWTH PIGS
Authors: Shakhov A.G. , Sashnina L.Yu. , Tarakanova K.V. , Karmanova N.V. , Vladimirova Yu.Yu.
Published: March 2022

The article presents the results of studies on the effect of Prostimul containing cytokines of the type 1, vitamins A, E, and C on the immune status, productivity, and safety of pigs that lag behind in growth and development. It was found that the drug, administered twice with an interval of 48 hours was followed by an increase in the immune status of animals, which was manifested by increasing in the serum the level of total protein, gamma globulins, total immunoglobulins, lysozymic and complementary activity, as well as the absorptive and digestive function of phagocytes, and a decrease in the level of circulating immune complexes and their pathogenicity. The use of Prostimul, accompanied by an increase in the immune status of pigs that retard in growth and devel-opment, had a positive effect on their productivity and safety. This allows the drug to be recommended for a wide use in industrial pig farming.
EFFICIENCY OF USING THE YORKSHIRE SOWS IN COMMERCIAL PIG FARMING
Authors: Yatusevich V.P. , Onufriyuk I.P.
Published: March 2022

The use of the Yorkshire sows in commercial pig farming both in purebred breeding and crossing with the Landras, Duroc and hybrid boars (L × D) and (Y × D) is effective and provides profit at a profitability level of 4.16-7.14%.
ESSENTIAL OILS AND THEIR COMPOSITIONS AS THE BASIS OF PREPARATIONS FOR INCLUSION IN THE METHOD OF INCREASING THE RESISTANCE OF POIKILOTHERMIC ANIMALS TO MICROORGANISMS OF THE GENUS AEROMONAS AND GENUS PROTEUS
Authors: Degtyarik S.M. , Poloz S.V. , Shutova A.G. , Maksimyuk Y.V. , Govor T.A.
Published: March 2022

In the course of studies, the antimicrobial activity of plant essential oils was assessed, the basic principles of de-velopment were determined and the compositions of compounds were proposed that can be used as a basis for prepara-tions for inclusion in the method of increasing the resistance of poikilothermic animals to microorganisms of the genus Aeromonas and the genus Proteus.
THE ROLE OF TOXOPLASMA GONDII IN THE REGULATION OF PROTOONCOGENES EXPRESSION IN THE EXPERIMENT
Authors: Pashinskaya E.S.
Published: March 2022

Brain glioma is the most common type of tumor that grows from glial tissue, which is made up of auxiliary cells of the nervous system. Gliomas account for about 60% of all tumors located in the brain.
Toxoplasma gondii is a parasite, the favorite location of which is the mammalian brain. In the tissues where the parasite is located, necrotic areas, cysts are formed, lesions of the brain and spinal cord, eyes and muscles are fixed. The mechanical, chemical influence of toxoplasmas leads to impaired brain activity, blindness, myositis, and myocarditis.
By now, it has not been studied whether the parasite can influence the regulation of carcinogenic processes at the molecular and genetic level.
The experiment showed that toxoplasmosis can lead to an increase in the expression of the proto-oncogenes survivin (BIRC5), VEGF, ErbB-2/HER2-Neu, GLI in the tissues of tumors, lungs, liver, spleen, and brain during the de-velopment of an experimental carcinogenic process. Infection of rats with glioma by toxoplasma is accompanied by a decrease in the expression of the anti-oncogene TP53 in the tumor tissues with its simultaneous growth in the lungs, liver, spleen, and brain.
MICROBIOLOGICAL AND CYTOLOGICAL INDICATORS OF MILK OF CLINICALLY HEALTHY COWS IN THE EARLY POSTPARTUM PERIOD WHEN USING THE PREPARATION «AMM»
Authors: Pasko N.V. , Zimnikov V.I. , Klimov N.T. , Pavlenko O. B. , Manzhurina O.A. , Kashirina L.N. , Tyurina E.V.
Published: March 2022

As a result of the studies it was found that the application of the preparation «AMM» contributed to the normalization of cytological and immunological indices of the udder secretion in clinically healthy cows within the postpartum period. At the end of the experiment, the contamination of milk with microflora decreased by 8.4 times, and bacteria carrying – by 2.5 times.
INFLUENCE OF DONORS ON THE EFFICIENCY OF OBTAINING EMBRYOS IN CULTURE IN VITRO
Authors: Golubets L.V.
Published: March 2022

In the process of research the influence of individual characteristics of donors on the efficiency of aspiration and obtaining embryos in culture in vitro was studied. As a result no regularity has been established for the effectiveness of aspiration and obtaining embryos in culture in vitro depending on their number. Thus, the number of aspirated follicles, depending on the donor, ranged from 3.7 to 8.2, the yield of viable oocytes from 55.1% to 96.4%, the level of cleavage from 41.7% to 95.1%, and the yield of embryos from 2.1% to 32.4%. There is a tendency for the average efficiency indicators to be increased as the aspiration serial number increases. Thus, the average yield of oocytes with an increase in the number of aspirations from one to nine was, depending on the donor, 2.3-4.8, and the yield of embryos was 0.1-0.7, with an increase in the number of aspirations from 11 to 14, -2.4-5.3 and 0.3 -0.7 and with an increase in number of aspirations from 15 to 22 - 3.9-9.7 and 0.6-1.8, respectively.
Fekete-Szegö problem for a subclass of analytic functions associated with Chebyshev polynomials
Authors: Çağlar Murat , Orhan Halit , Kamali Muhammet
Published: March 2022

In this paper, we obtain initial coefficients |a2| and |a3| for a certain subclass by means of Chebyshev polynomials expansions of analytic functions in D. Also, we solve Fekete-Szegö problem for functions in this subclass.
Global existence and stability of solution for a p-Kirchhoff type hyperboc equation with variable exponents
Authors: Ouaoua Amar , Khaldi Aya , Maouni Messaoud
Published: March 2022

In this paper, we consider the following p-Kirchhoff type hyperboc equation with variable exponents Equation We prove that a global existence of the solution with positive initial energy, the stability based of Komorniks inequality.
THE CURRENT STATE OF AGRICULTURAL LENDING IN KAZAKHSTAN
Authors: Duskaliyev А. , Tyumambayeva А. , Abdeshova А.
Published: March 2022

The purpose of the research is to identify problems on the basis of theoretical and methodological developments to increase the need for a loan in the agricultural sector of the Republic of Kazakhstan and develop recommendations for their solution.

Methodology. In this study, the authors attempted to analyze agricultural lending and identify the factors that influence the success of the industry. The article used methods typical for economic research: an economic statistical method based on data grouping, a comparative method, a tabular method and a generalization method.

Originality / value of the research. The research results can be used in the development of programs to expand the financing channels for lending to the agricultural sector, change the mechanism for subsidizing the development of agricultural production.

Findings. This article analyzes the available credit resources for the agricultural sector, and also proposes various programs for lending to the agricultural sector from different sources. Problems in the country with regard to lending to the agricultural sector were identified and recommendations were made to reduce and resolve them.
RESEARCH OF THE YOUTH LABOR MARKET IN THE CONTEXT OF A PANDEMIC
Authors: Sabirova R. K. , Karimbaeva G. Zh. , Dzhumaeva A. K.
Published: March 2022

The purpose of this article is to study the public opinion of the youth of Kazakhstan on the problem of employment, labor market and labor migration, as well as to develop proposals for regulating the youth labor market.

Research methodology. On the territory of 14 regions of Kazakhstan and 3 cities of republican signifycance: Nur-Sultan, Almaty and Shymkent, Atyrau city and 7 districts in Atyrau region, a survey of young people on the social well-being of young people aged 18-25 in Kazakhstan, including employment problems, labor market and labor migration was conducted. The survey was attended by young people of the Republic of Kazakhstan aged 18 to 25 years. The total volume of the sample set of studies was 4 000 people.

Originality / value of the research. The problems related to the labor market and labor migration of young people of the Republic of Kazakhstan under "COVID-19" have been identified.

Findings. The article deals with the issues of the youth labor market in Kazakhstan, youth unemployment and youth labor migration, and based on the results of the survey, recommendations are given on state regulation of the youth labor market. In particular, state support for entrepreneurship in the field of youth employment, digitalization of labor market infrastructure, development of youth professional skills.
RATING EVALUATION OF THE UNIVERSITIES-BUSINESS INTERACTION EFFICIENCY BY REGIONS OF KAZAKHSTAN
Authors: Drakh T. P. , Salzhanova Z. A. , Vitrenko A.
Published: March 2022

Purpose of the research. The article is devoted to highlighting and analyzing the results of the rating evaluation of the universities-business interaction effectiveness based on the calculation of the integral indicator at the meso-level in the regions of the Republic of Kazakhstan for making further decisions in the development of regional policy in the field of higher education and support for universities in those regions that most effectively interact with the real sector of the economy.

Methodology. The study used a methodical approach to the calculation of the integral indicator.

 Originality / value of the research. This evaluation allows to determine the universities-business interaction effectiveness in the regions objectively on the basis of available statistical data.

 Findings. The evaluation has made it possible to determine that the leaders of the regional ranking are regions with a high level of educational and scientific potential.
Challenges of Ending the Rwandan Refugee Problem in Uganda; The relationship between the Old Case Loads and New Case Loads
Authors: Justus Asasira , Winfred Aliguma
Published: March 2022

Uganda is home to over 1 million refugees and asylum seekers. The origin of refugees in Uganda is an unending crisis in the neighboring countries. Rwanda poses a big threat of ending the refugee problem as the host country has accommodated these refugees for over decades with no hopes to return. The two strands (old and new cases loads) make repatriation challenging due to divergent views and attitudes. The paper examines the relationship between the two strands of Rwandan refugees living in Nakivale settlement. Another niche in this paper is focused on how these refugees live with the host communities of Ugandan origin living around the settlement and answers partly why voluntary repatriation has not been realized among Rwandan refugees living in Uganda.
Edith Wharton and the Architect
Authors: Orlando Emily J.
Published: March 2022

To date, the only scholarly attention paid to the two abandoned Wharton novels called “The Keys of Heaven” has focused on the “Praslin version,” a retelling of a murder-suicide from 1840s Paris. The “Olney-Beecher version” concerns a woman named Catherine Beecher, her would-be lover Jacob Olney, and her husband, a New England architect who sounds a lot like Ogden Codman Jr., with whom Wharton wrote The Decoration of Houses. This overlooked material evidently from the mid-1920s should be of interest to scholars for the potential light it sheds on her writing from the period and on the status of her rift with Codman. The evidence suggests that Wharton's fictional narratives moved from a place where she was writing in “one long shriek” to a space where she could imagine a lover turning the handle of that inner door and crossing the threshold into a room full of treasures awaiting discovery.
Investigation of biomarkers in the anterior chamber aqueous humor and the vitreous body in patients with neovascular glaucoma and diabetes mellitus
Authors: Biletskaya V. A. , Lipatov D. V. , Frolov M. A. , Surguch V. K. , Frolov A. M.
Published: March 2022

PURPOSE. To study possible biomarkers of proliferative diabetic retinopathy complicated by neovascular glaucoma and hemophthalmos located in the aqueous humor of the anterior chamber of the eye and the vitreous body, and to evaluate their role in the pathogenesis of pathological neovascularization in diabetes mellitus.

METHODS. Samples were taken from the anterior chamber aqueous humor of 7 patients with type 2 diabetes mellitus and operated neovascular glaucoma (Ahmed valve), as well as from the vitreous body of the same patients who underwent vitrectomy after drainage surgery due to long-term total hemophthalmos. The comparison group consisted of patients without diabetes mellitus, who also had aqueous humor samples taken from the anterior chamber of the eye and vitreous. Concentration of markers was assessed by multiplex immune analysis.

RESULTS. A significant increase in the levels of selected markers relative to the control group (patients without diabetes mellitus) was found in the aqueous humor of the anterior chamber and the vitreous body. The concentration of some cytokines differed significantly in the experimental and control groups suggesting the possibility of their evaluation for early detection of a more severe course of diabetic retinopathy.

CONCLUSION. The obtained results expand the knowledge about the pathogenesis of neovascular glaucoma and confirm the importance of further study of the immunological aspects of pathological neovascularization in diabetes mellitus. This allows us to take a fresh look at the role of biomarkers in the process and indicates their connection with the activation and support of the pathological chain of the process of new vessels formation.
Evaluation of the effectiveness of frequency doubling technology perimetry in the diagnosis of optic neuropathies
Authors: Simakova I. L. , Tikhonovskaya I. A.
Published: March 2022

PURPOSE. To compare the diagnostic effectiveness of two perimetric threshold strategies with frequency-doubling technology in patients with early primary open-angle glaucoma (POAG), the optical form of multiple sclerosis (MS) and papilledema in an open-label comparative clinical study.

MATERIAL AND METHODS. The study involved 78 patients (105 eyes) with optic neuropathies (ON). The patients were divided into 3 groups depending on the etiology of optic neuropathy: the first group included 30 patients (46 eyes) with early POAG aged 30 to 65 years (54.9±1.3); the second group included 26 patients (26 eyes) diagnosed with the optic form of MS (an episode of retrobulbar optic neuritis in the medical history) aged 22 to 44 years (33.7±6.5); the third group consisted of 22 patients (33 eyes) aged from 18 to 66 years (35.7±14.9) with papilledema caused in the majority of cases by various brain tumors (25 eyes or 75.7%). The fourth (control) group consisted of 60 healthy individuals (60 eyes) aged 20 to 65 years, who were divided into 2 equal subgroups – younger (24.8±4.4) and older (56.4±3.9).

Standard and non-standard perimetry was performed on all subjects during a comprehensive ophthalmic examination using the Humphrey 745i Visual Field Analyzer II (HFA II, «24-2» threshold strategy) (Germany-USA) and the author's own modification of Frequency Doubling Technology (FDT) Perimetry, in the form of 2 threshold strategies: the well-known «FDT-16» and the new «FDT-64».

RESULTS. Both the «FDT-16» and the «FDT-64» threshold strategies were more effective in diagnosing glaucomatous optic neuropathy (GON), as confirmed by the higher sensitivity of their results to two criteria — the number of identified scotomas (n of scotomas n≥2), and the number of scotoma clusters in patients with POAG (88 and 100%; 95 and 83%, respectively) compared with those in patients with MS (61 and 76%; 85 and 54%, respectively) and papilledema (51 and 78%; 88 and 70%, respectively). The specificity of the «FDT-16» and «FDT-64» threshold strategies was significantly higher than the specificity of Humphrey perimetry (100, 80 and 63%, respectively).

CONCLUSION. Both perimetric threshold strategies with frequency-doubling technology were found to be the most effective in detecting GON. This confirms that they are more sensitive in patients with early POAG when compared with the sensitivity in patients with MS and papilledema. The level of specificity of both FDT perimetry strategies far exceeds the level of specificity of Humphrey perimetry data, which indicates the advantage of FDT perimetry in separating healthy people from patients with ON, and not only of glaucoma genesis.
Comparative assessment of the potential impact of chronic herpesvirus infection on intra- and postoperative complications in patients with glaucoma
Authors: Erichev V. P. , Abdullaeva E. H. , Mazurova Yu. V.
Published: March 2022

PURPOSE. To evaluate the potential impact of herpesvirus infection (carriage) on early postoperative outcomes of antiglaucoma surgeries.

MATERIAL AND METHODS. The study included 95 patients with stage I, II and III primary open-angle glaucoma (POAG), with indications for surgical treatment. The patients were divided into the main group (group 1, 31 patient) and the control group (group 2, 64 patients). The groups were formed on the basis of information obtained from the anamnesis about a transferred herpes simplex virus of any localization (as a rule, it was labial, oral-facial herpes and its skin manifestation). The indication for surgical treatment was the absence of persistent normalization of intraocular pressure and a decrease in visual functions. Depending on the clinical situation, patients underwent one of the two types of surgical interventions: trabeculectomy and non-penetrating deep sclerectomy. Analysis of postoperative complications was performed on day 7 after surgery.

RESULTS. The most frequent complications in the early postoperative period were ciliochoroidal detachment, hyphema, increased intraocular pressure, shallow anterior chamber syndrome, excessive vascularization in the surgery site, clinical signs of conjunctival-scleral and sclerascleral scarring. On day 7 after antiglaucoma surgery, the IOP level was 9.1±0.8 mm Hg on average in the groups. IOP was 1–2 mm Hg higher in case of non-penetrating surgery. In the same patients, normalization of IOP by the same date was obtained in 63.15% of cases, which required goniopuncture; needling was indicated and performed in 84.2% of patients. Ciliochoroidal detachment was diagnosed in both groups with the same frequency: 9.7 and 9.4%, respectively. Presence of minor hyphema was observed only after trabeculectomy, in 16.1 and 10.9% of cases, respectively.

CONCLUSION. Results of this study, firstly, do not indicate that HSV activates in response to surgical intervention; secondly, in patients who had been infected with it previously, only a tendency for the number of most common intra- and postoperative complications to increase was noted. The obtained results are insufficient for an unambiguous answer to the question posed in this study, which indicates the need for further research.
Additional professional education of medical doctors and clinical practice results (analytical online study)
Authors: Movsisyan A. B. , Kuroyedov A. V. , Zavadski P. Ch. , Brezhnev A. Yu. , Abdrakhmanova E. S. , Gorodnichy V. V.
Published: March 2022

PURPOSE. To study the opinion of ophthalmologists about the usefulness of training programs presented on the continuing medical education (CME) web portal, their significance and impact on the process of obtaining knowledge in modern conditions, when the scene is dominated by hybrid forms of education.

MATERIAL AND METHODS. This study was multicenter scientific and analytical selective cross-sectional observational in design and was conducted in the period from June to September 2021; it was based on the data obtained by an online survey among Russian ophthalmologists with varying records and/or work experience, employed at institutions of different forms of ownership. The prepared questionnaire included two groups of questions: general statistical data and special questions related to the topic "glaucoma".

RESULTS. The study involved 1113 clinically practicing ophthalmologists (88%), with an average medical experience of 18 (0; 50) years, without medical category (35%), and have a polyclinic as their main place of work (77%). According to the survey results, 46% of respondents give a high assessment of the content of educational programs, 35% — negative. When choosing therapeutic and diagnostic tactics, doctors prefer their own clinical experience (36.4%), while the main source of knowledge today is the CME training courses (30.8%). According to respondents, the target level of intraocular pressure is achieved in clinical practice in around 71% of cases, which is facilitated by the comprehensive approach to treatment (47%). At the same time, according to the majority of specialists (71%), only 25% of patients achieve target intraocular pressure.

CONCLUSION. Representativeness of the sample is beyond doubt. Registration on the CME web portal, in general, does not depend on work experience, attitude to educational organizations, or place of work. With increase in work experience, there is an increase in the number of positive responses characterizing the information completeness of the CME training courses (from 39.7% to 61.8%). CME programs in the field of glaucoma and comorbid ophthalmic pathologies require adaptation taking into account personal skill levels of ophthalmologists.
Land-Use/ Land-Cover Changing Trends and their Relation to Landslides: A Case Study of Hali-Ela in Badulla District, Sri Lanka
Authors: Alahakoon A.M.R.N.K. , Thisara Sathsara K.L. , Arachchige Udara S.P.R. , Subasinghea Shyamantha
Published: March 2022

The study has evaluated the impact of Land-use/Land Cover (LULC) in a period of 65 years from 1956 to 2021 on landslides occurrence in Hali-Ela Divisional Secretariat Division (HDSD) in Badulla District, Sri Lanka. LULC distribution patterns were evaluated by comparing thematic maps prepared for three different years. These maps were overlaid with spatial distribution of total landslides and each type of landslides in a Geographic Information System (GIS) to assess their spatial frequency distribution and relative failure potentials related to selected topographic attributes LULC type in that particular area. The spatial analysis results revealed a close relationship between the topographic attributes of the post-landslides, local surface and LULC changes. And also, in the study area the forest area has decreased by more than 45%, whereas home garden has increased by 27% for the study period of 65 years. It is clear that changes in vegetation cover affect the landslide frequency distribution and landslides are highly dependent on LULC changes. Poorly managed tea land, home gardens on steep slopes and poorly managed open forest areas are more vulnerable to landslides.