bluuebunny/crossref_metadata_2025 huggingface dataset:
Resection of the Primary Tumor Improves the Survival of Patients With Stage IV Gastric Neuroendocrine Carcinoma
Authors: Li Zefeng , Ren Hu , Wang Tongbo , Zhang Xiaojie , Zhao Lulu , Sun Chongyuan , Niu Penghui , Guo Chunguang , Chen Yingtai , Zhao Dongbing
Published: July 2022

Background

The prognostic prolongation effect of surgical resection in the management of gastric neuroendocrine carcinoma (GNEC) with distant metastases was still uncertain. The purpose of this study was to investigate the association of primary tumor resection (PTR) with outcomes in patients with stage IV GNEC.

Methods

This retrospective study analyzed patients with distant metastatic GNEC diagnosed between 2000 and 2018 and identified using the Surveillance, Epidemiology, and End Results (SEER) database. Patients were divided into PTR and non-PTR groups. The stabilized inverse probability of treatment weighting (IPTW) method was used to reduce the selection bias. Overall survival (OS) and cancer-specific survival (CSS) were estimated using the Kaplan–Meier method and log-rank test. Cox-regression analyses (uni- and multivariate) were performed to evaluate factors potentially influencing survival.

Results

A total of 126 patients with a median follow-up of 79 months were identified. Forty-four patients underwent PTR and 82 patients did not undergo surgery. After the IPTW approach, PTR improved the OS in patients with stage IV GNEC (median OS 12 vs. 6 months, P = 0.010). The 1- and 3-year OS for patients with or without PTR were 43.8% and 34.5%, and 27.9% and 6.5%, respectively. The median CSS was 12 months for patients undergoing PTR and 6 months for those who did not. The 1 and 3-year CSS for patients with or without PTR were 45.1% and 37.0%, and 27.9% and 6.5%, respectively. In IPTW-adjusted Cox proportional hazards regression analysis, PTR was recognized as an independent factor for improved survival after the occurrence of distant metastatic disease [OS: hazard ratio (HR) = 0.305; 95% confidence interval (CI): 0.196, 0.475; and CSS: HR = 0.278; 95% CI: 0.171, 0.452].

Conclusion

PTR for stage IV GNEC contributes to a better prognosis compared with non-surgery. This study supported the resection of the primary tumor in patients with distant metastatic GNEC.
Identification of a 3-Gene Model as Prognostic Biomarker in Patients With Gastric Cancer
Authors: Xue Siming , Zheng Tianjiao , Yan Juan , Ma Jinmin , Lin Cong , Dong Shichen , Wei Chen , Li Tong , Zhang Xiaoyin , Li Guibo
Published: July 2022

Objective

Although the incidence of gastric cancer (GC) is decreasing, GC remains one of the leading cancers in the world. Surgical resection, radiotherapy, chemotherapy, and neoadjuvant therapy have advanced, but patients still face the risk of recurrence and poor prognosis. This study provides new insights for assessment of prognosis and postoperative recurrence of GC patients.

Methods

We collected paired cancer and adjacent tissues of 17 patients with early primary GC for bulk transcriptome sequencing. By comparing the transcriptome information of cancer and adjacent cancer, 321 differentially expressed genes (DEGs) were identified. These DEGs were further screened and analyzed with the GC cohort of TCGA to establish a 3-gene prognostic model (PLCL1, PLOD2 and ABCA6). At the same time, the predictive ability of this risk model is validated in multiple public data sets. Besides, the differences in immune cells proportion between the high- and low-risk groups were analyzed by the CIBERSORT algorithm with the Leukocyte signature matrix (LM22) gene signature to reveal the role of the immune microenvironment in the occurrence and development of GC.

Results

The model could divide GC samples from TCGA cohorts into two groups with significant differences in overall and disease-free survival. The excellent predictive ability of this model was also validated in multiple other public data sets. The proportion of these immune cells such as resting mast cells, T cells CD4+ memory activated and Macrophages M2 are significantly different between high and low risk group.

Conclusion

These three genes used to build the models were validated as biomarkers for predicting tumor recurrence and survival. They may have potential significance for the treatment and diagnosis of patients in the future, and may also promote the development of targeted drugs.
A Survey of the Practice Status Quo of Ultrasound-Guided ECC Tip Location for Neonatal Patients in 31 Provinces of China
Authors: Liu Xuexiu , Tao Xiaojun , Xu Ye , Zhang Xianhong , Wu Liping
Published: July 2022

Objective

To investigate the status quo of implementing ultrasound (US)-guided epicutaneo-caval catheters (ECC) tip location for neonatal patients in 31 provinces.

Methods

The convenience sampling method was used to investigate the nursing managers and ECC (or intravenous therapy) nurses of 91 hospitals in 31 provinces from October 29 to November 10, 2021.

Results

The survey involved a total of 182 medical staff, including 91 managers and 91 nurses, and 91 institutions, including 22 children's hospitals, 49 general hospitals and 21 maternal and child health care hospitals. Sixteen hospitals (17.6%) carried out US-guided ECC for neonatal patients; 176 subjects (96.7%) of the 91 hospitals had known about or heard of the technology of US-guided ECC. The low awareness of operators of the tip location of ECC catheters in children under ultrasound guidance (OR = 2.690, 95% CI = 1.163–6.221), limited conditions in existing wards (OR = 2.953, 95% CI = 1.285–6.790), and insufficient funds (OR = 2.836, 95% CI = 1.149–7.004) were the independent risk factors responsible for the failure to carry out ultrasonic-guided location of ECC tips in newborns.

Conclusion

The popularity of neonatal US-guided ECC location was seriously hindered by factors such as a low awareness rate of the project, the low qualification certification rate of the nursing staff, a flawed performance allocation system, and the lack of a professional team, among other factors.
Long-term oral administration of naringenin counteracts aging-related retinal degeneration via regulation of mitochondrial dynamics and autophagy
Authors: Chen Guiping , Zeng Ling , Yan Feng , Liu Jinlong , Qin Mengqi , Wang Feifei , Zhang Xu
Published: July 2022

Aging-related retinal degeneration can manifest as decreased visual function due to damage to retinal structures and dysfunction in retinal homeostasis. Naringenin, a flavonoid, has beneficial effects in preventing cellular aging, preserving the functionality of photoreceptors, and slowing down visual function loss. However, the role and potential mechanism of naringenin in the aging mouse retina require further investigation. In this study, we evaluated the effects of naringenin on the aging eye using electroretinogram (ERG) and hematoxylin and eosin staining and explored its potential mechanism by western blotting. ERG showed that naringenin increased the amplitude of the a- and b-waves of scotopic 3.0, 10.0, and the a-wave amplitude of photopic 3.0 in the aging mouse retina. Furthermore, administration of naringenin prevented aging-induced retinal degeneration in the total retina, ganglion cell, inner plexiform layer, inner nuclear layer, and outer nuclear layer. The expression of mitochondrial fusion protein two was increased, OPA1 protein expression and the ratio of L-OPA1/S-OPA1 were unchanged, and dynamin-related protein one was decreased in the 12-month-old mice treated with naringenin compared with the 12-month-old mice treated with vehicle. Furthermore, the downregulation of age-related alterations in autophagy was significantly rescued in the aging mice by treatment with naringenin. Taken together, these results suggest that the oral administration of naringenin improves visual function, retinal structure, mitochondrial dynamics, and autophagy in the aging mouse retinas. Naringenin may be a potential dietary supplement for the prevention or treatment of aging-related retinal degeneration.
Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest
Authors: Han Bingjie , Sun Yuanyuan , Zhang Xiaofen , Yue Ping , Tian Meiling , Yan Dan , Yin Fanxiang , Qin Bo , Zhao Yi
Published: July 2022

The occurrence of cisplatin resistance is still the main factor limiting the therapeutic effect of non-small cell lung cancer (NSCLC). It is urgent to elucidate the resistance mechanism and develop novel treatment strategies. Targeted metabolomics was first performed to detect amino acids’ content in cisplatin-resistant cancer cells considering the relationship between tumour metabolic rearrangement and chemotherapy resistance and chemotherapy resistance. We discovered that levels of most amino acids were significantly downregulated, whereas exogenous supplementation of proline could enhance the sensitivity of NSCLC cells to cisplatin, evidenced by inhibited cell viability and tumour growth in vitro and xenograft models. In addition, the combined treatment of proline and cisplatin suppressed ATP production through disruption of the TCA cycle and oxidative phosphorylation. Furthermore, transcriptomic analysis identified the cell cycle as the top enriched pathway in co-therapy cells, accompanied by significant down-regulation of PLK1, a serine/threonine-protein kinase. Mechanistic studies revealed that PLK1 inhibitor (BI2536) and CDDP have synergistic inhibitory effects on NSCLC cells, and cells transfected with lentivirus expressing shPLK1 showed significantly increased toxicity to cisplatin. Inhibition of PLK1 inactivated AMPK, a primary regulator of cellular energy homeostasis, ultimately leading to cell cycle arrest via FOXO3A-FOXM1 axis mediated transcriptional inhibition in cisplatin-resistant cells. In conclusion, our study demonstrates that exogenous proline exerts an adjuvant therapeutic effect on cisplatin resistance, and PLK1 may be considered an attractive target for the clinical treatment of cisplatin resistance in NSCLC.
Adjusting the Trapping Process of a Directed Weighted Edge-Iteration Network
Authors: Su Jing , Ma Mingyuan , Zhang Mingjun , Yao Bing
Published: July 2022

Controlling the trapping process is one of the important themes in the study of random walk in real complex systems. We studied two types of random walks that are different from the traditional random walk on a directed weighted network. The first type of random walk is the weighted random walk controlled by the weight θ, and the other is the delayed-weighted random walk affected by both delay probability p and weight θ. Furthermore, we derived analytically the average trapping time (ATT) measuring the efficiency of the two types of trapping processes; the result shows that the ATT grows sub-linearly, linearly, and super-linearly with the network order when the weight satisfies θ<32, θ=32, and θ>32 , respectively. The weight θ of the directed network can be adjusted by direction, the delay parameter p only changes the pre-factor of the ATT, and the weight θ modifies both the pre-factor and scaling of the ATT.
Aquatic Contamination in Lugano Lake (Lugano Lake Ecological Reserve, Buenos Aires, Argentina) Cause Negative Effects on the Reproduction and Juvenile Survival of the Native Gastropod Biomphalaria straminea
Authors: Paredes María Gimena , Bianco Karina Alesia , Menéndez-Helman Renata J. , Kristoff Gisela
Published: July 2022

Lugano Lake is located in an Ecological Reserve of Buenos Aires City. Biomonitoring of its water quality is essential due to its importance as a place for recreation and protection of native species. Biomphalaria straminea is a native hermaphrodite aquatic gastropod that inhabits different freshwater bodies of Argentina and was recently selected as a potential bioindicator. We propose this study as a first approach to assessing specific organisms’ use in biomonitoring of urban wild reserves, and the usefulness of reproduction assays. B. straminea survival, behavior, reproduction success and offspring survival after the exposure to water samples from Lugano Lake (L1, L2, and L3) were evaluated. Temperature, pH, conductivity and dissolved oxygen were registered in situ. Samples were transported to the laboratory and chemical analysis and bioassays were performed using 20 snails per site. A control group with tap water was added. Egg masses were separated, exposed individually and observed daily using a stereoscopic microscope. After hatching, juveniles were placed in tap water and offspring survival was registered at the first, second, third and fourth months after the beginning of the assay. High levels of conductivity, turbidity and nutrients were obtained. Ammonium and nitrite were higher than the guideline level for the protection of aquatic life. During the bioassay 20% of the snails (L2 and L3) showed abnormally protruding of the head-food region. The number of eggs and embryonated eggs per mass did not differ between treatments. Egg masses exposed to water samples from the lake presented overlapping and abnormal eggs and arrested embryos. Besides, low % of hatching (L1: 33%, L2: 42%, and L3: 16%) and juvenile survival after the first (L1:14%; L2:78%) and second month (L1: 60%) were noted. In the control group, 85% of hatching and 100%–90% of survival were observed. Our results suggests the presence of pollutant in the lake. B. straminea seems to be a sensitive local species. Biomphalaria spp. reproduction assays can provide a valuable endpoint for toxicity and risk assessments and a usefulness tool for biomonitoring water quality.
The Reciprocal Effect of Elevated CO2 and Drought on Wheat-Aphid Interaction System
Authors: Xie Haicui , Shi Fengyu , Li Jingshi , Yu Miaomiao , Yang Xuetao , Li Yun , Fan Jia
Published: July 2022

Due to the rising concentration of atmospheric CO2, climate change is predicted to intensify episodes of drought. However, our understanding of how combined environmental conditions, such as elevated CO2 and drought together, will influence crop-insect interactions is limited. In the present study, the direct effects of combined elevated CO2 and drought stress on wheat (Triticum aestivum) nutritional quality and insect resistance, and the indirect effects on the grain aphid (Sitobion miscanthi) performance were investigated. The results showed that, in wheat, elevated CO2 alleviated low water content caused by drought stress. Both elevated CO2 and drought promoted soluble sugar accumulation. However, opposite effects were found on amino acid content—it was decreased by elevated CO2 and increased by drought. Further, elevated CO2 down-regulated the jasmonic acid (JA) -dependent defense, but up-regulated the salicylic acid (SA)-dependent defense. Meanwhile, drought enhanced abscisic acid accumulation that promoted the JA-dependent defense. For aphids, their feeding always induced phytohormone resistance in wheat under either elevated CO2 or drought conditions. Similar aphid performance between the control and the combined two factors were observed. We concluded that the aphid damage suffered by wheat in the future under combined elevated CO2 and drier conditions tends to maintain the status quo. We further revealed the mechanism by which it happened from the aspects of wheat water content, nutrition, and resistance to aphids.
Genomic Regions Associated With Seed Meal Quality Traits in Brassica napus Germplasm
Authors: Bhinder Gurleen , Sharma Sanjula , Kaur Harjeevan , Akhatar Javed , Mittal Meenakshi , Sandhu Surinder
Published: July 2022

The defatted Brassica napus (rapeseed) meal can be high-protein feed for livestock as the protein value of rapeseed meal is higher than that of the majority of other vegetable proteins. Extensive work has already been carried out on developing canola rapeseed where the focus was on reducing erucic acid and glucosinolate content, with less consideration to other antinutritional factors such as tannin, phytate, sinapine, crude fiber, etc. The presence of these antinutrients limits the use and marketing of rapeseed meals and a significant amount of it goes unused and ends up as waste. We investigated the genetic architecture of crude protein, methionine, tryptophan, total phenols, β-carotene, glucosinolates (GLSs), phytate, tannins, sinapine, and crude fiber content of defatted seed meal samples by conducting a genome-wide association study (GWAS), using a diversity panel comprising 96 B. napus genotypes. Genotyping by sequencing was used to identify 77,889 SNPs, spread over 19 chromosomes. Genetic diversity and phenotypic variations were generally high for the studied traits. A total of eleven genotypes were identified which showed high-quality protein, high antioxidants, and lower amount of antinutrients. A significant negative correlation between protein and limiting amino acids and a significant positive correlation between GLS and phytic acid were observed. General and mixed linear models were used to estimate the association between the SNP markers and the seed quality traits and quantile-quantile (QQ) plots were generated to allow the best-fit algorithm. Annotation of genomic regions around associated SNPs helped to predict various trait-related candidates such as ASP2 and EMB1027 (amino acid biosynthesis); HEMA2, GLU1, and PGM (tryptophan biosynthesis); MS3, CYSD1, and MTO1 (methionine biosynthesis); LYC (β-carotene biosynthesis); HDR and ISPF (MEP pathway); COS1 (riboflavin synthesis); UGT (phenolics biosynthesis); NAC073 (cellulose and hemicellulose biosynthesis); CYT1 (cellulose biosynthesis); BGLU45 and BGLU46 (lignin biosynthesis); SOT12 and UGT88A1 (flavonoid pathway); and CYP79A2, DIN2, and GSTT2 (GLS metabolism), etc. The functional validation of these candidate genes could confirm key seed meal quality genes for germplasm enhancement programs directed at improving protein quality and reducing the antinutritional components in B. napus.
Changes in Vertical Phenotypic Traits of Rice (Oryza sativa L.) Response to Water Stress
Authors: Zhang Yufan , Zha Yuanyuan , Jin Xiuliang , Wang Yu , Qiao Han
Published: July 2022

Drought-rehydration irrigation has an enhancing impact on rice yield, but the current research on its yield-increasing effect is mainly experimental and empirical, lacking mechanism theoretical support. Image-based machine vision is rapidly developing and can estimate crop physical and chemical properties. A novel image processing method has been purposefully carried out to detect the real-time response shape of rice drought-rehydration. By application of this method, two new types of morphological descriptors were proposed to characterize and quantify the vertical phenotypic heterogeneity of rice, in which the relative height of the plant centroid (RHC) locates the growth focus, while the leaf angle distribution model describes the vertical characteristics of the leaf phenotypic traits. We verified the response of the vertical traits to different water treatments through designed experiments. The results showed that the RHC and leaf angle distribution parameters followed divergent trends under water stress, reflecting the drought characteristics of rice at different growth stages. The newly developed indicators were sensitive to drought response at specific growth stages and also efficient for evaluating rice growth, including determination of radiation interception capacity and assessment of nutrient accumulation. Furthermore, through the measurement and analysis of vertical structural traits, we found that a short-term water deficit and reasonable rehydration during the rice heading period could help to extend the spike-growing time and improve photosynthetic efficiency, thus benefiting yield formation.
Genome-Wide Analysis of Anthocyanin Biosynthesis Regulatory WD40 Gene FcTTG1 and Related Family in Ficus carica L.
Authors: Fan Zhiyi , Zhai Yanlei , Wang Yuan , Zhang Long , Song Miaoyu , Flaishman Moshe A. , Ma Huiqin
Published: July 2022

WD40 proteins serve as crucial regulators in a broad spectrum of plant developmental and physiological processes, including anthocyanin biosynthesis. However, in fig (Ficus carica L.), neither the WD40 family nor any member involved in anthocyanin biosynthesis has been elucidated. In the present study, 204 WD40 genes were identified from the fig genome and phylogenetically classified into 5 clusters and 12 subfamilies. Bioinformatics analysis prediction localized 109, 69, and 26 FcWD40 proteins to the cytoplasm, nucleus and other cellular compartments, respectively. RNA-seq data mining revealed 127 FcWD40s expressed at FPKM > 10 in fig fruit. Most of these genes demonstrated higher expression in the early stages of fruit development. FcWD40-97 was recruited according to three criteria: high expression in fig fruit, predicted nuclear localization, and closest clustering with TTG1s identified in other plants. FcWD40-97, encoding 339 amino acids including 5 WD-repeat motifs, showed 88.01 and 87.94% amino acid sequence similarity to apple and peach TTG1, respectively. The gene is located on fig chromosome 4, and is composed of 1 intron and 2 exons. Promoter analysis revealed multiple light-responsive elements, one salicylic acid-responsive element, three methyl jasmonate-responsive elements, and one MYB-binding site involved in flavonoid biosynthesis gene regulation. FcWD40-97 was in the FPKM > 100 expression level group in fig fruit, and higher expression was consistently found in the peel compared to the flesh at the same development stages. Expression level did not change significantly under light deprivation, whereas in leaves and roots, its expression was relatively low. Transient expression verified FcWD40-97’s localization to the nucleus. Yeast two-hybrid (Y2H) and biomolecular fluorescence complementation (BiFC) assays revealed that FcWD40-97 interacts with FcMYB114, FcMYB123, and FcbHLH42 proteins in vitro and in vivo, showing that FcWD40-97 functions as a member of the MYB–bHLH–WD40 (MBW) complex in anthocyanin-biosynthesis regulation in fig. We therefore renamed FcWD40-97 as FcTTG1. Our results provide the first systematic analysis of the FcWD40 family and identification of FcTTG1 in fig pigmentation.
Nexus Between Financial Events and Emotional Exhaustion: Mediating Roles of Deliberate Thinking and Negative Interpersonal Events
Authors: Yang Liwei
Published: July 2022

Financial stress and emotional exhaustion have become prevalent elements of modern society, especially after COVID-19. This pandemic has changed people’s lives, particularly in a negative way. Individuals have begun to face the stress and emotional exhaustion associated with particular financial stressor events. However, limited studies have analyzed the relationship between financial stressor events and emotional exhaustion to date. Therefore, the current study aims to explore the relationship between different financial stressor events in an individual’s life and emotional exhaustion based on their well-being. This study also identifies the variables that play a mediating role in assessing the relationship between emotional exhaustion and financial stressor events. To achieve this, the researcher collected data from employees working in large organizations in May 2021 and December 2021. The study employs path analysis to assess the relationship between the identified variables. The study found that both organizations and employees are directly affected by financial stress, leading to emotional exhaustion or a decline in the mental well-being of the individuals. In addition, the study also found that financial stress and emotional exhaustion can directly affect the physical health of individuals. The study further revealed that deliberate thinking, negative interpersonal events, and individual characteristics are some of the identified variables that act as mediators between financial stressor events and emotional exhaustion.
Spatial Difference of China’s Regional Logistics Development and Construction of Information Network Platform Based on Artificial Intelligence Technology Under the Background of New Economy
Authors: Zhao Shajunyi , Xie Cuijie
Published: July 2022

Regional logistics is an important part of the regional economy. It plays an important role in optimizing the allocation of regional resources, promoting the upgrading of regional industrial structure, and promoting the sustainable development of regional economy. It is known as the “accelerator” of regional economic growth. Under the background of the expanding regional economic differences in China, this article focuses on the important components of regional economy, researching on regional logistics in different regions. This article focuses on the regional logistics development level, the internal mechanism of regional logistics promoting regional economic growth, the current situation and influencing factors of regional logistics development level differences, and the regional logistics development level differences. The purpose of this article is to study the application of artificial intelligence technology to the spatial difference analysis of China’s regional logistics development and the construction of information network platform under the background of the new economy. In this article, factor analysis is used to construct the index system. The research shows that the intensity of regional logistics connection is significantly enhanced, the regional logistics network is further improved, and a relatively complete multilevel regional logistics network structure is basically formed. In addition, there are great differences in the level of logistics development among regions. The characteristics of the spatial distribution circle in the eastern, central, and western regions are obvious, which is positively related to the economic development, in the Pearl River Delta with the strongest comprehensive competitiveness. The score coefficient of the Yangtze River Delta logistics area is 1.464, and the score coefficient of the northwest logistics weakest area is −0.328. The development of regional logistics can focus on the construction of logistics park, the construction of logistics network system, the progress of regional logistics technology, and the improvement of logistics efficiency. The construction of logistics park is conducive to the integration of regional logistics resources, improves the utilization efficiency of regional logistics resources, forms the economies of scale, and then reduces the transaction cost of the whole region.
RETRACTED: Neural Correlates of Handwriting Effects in L2 Learners
Authors: Li Yifei , Guan Connie Qun
Published: July 2022

Learning to write involves integrating motor production and visual perception to develop orthographic representations. This study tries to test the effect of hand movement training as a pathway to neural correlates for L2 Chinese and L2 English readers. Twenty L2 Chinese and 20 L2 English (n = 20) adults participated in both behavioral and electroencephalogram (EEG) experiments. We designed six learning conditions: Hand Writing Chinese (HC), Viewing Chinese (VC), Drawing followed by Character Recognition in Chinese (DC), Hand Writing English (HE), Viewing English (VE), and Drawing followed by Word Recognition in English (DE). Behavioral and EEG results demonstrated that drawing facilitated visual word recognition in Chinese compared to viewing. The findings imply that hand movement could strengthen the neural processing and improve behavioral performance in Chinese character recognition for L2 Chinese learners and English word recognition for L2 Chinese learners. Furthermore, N170 amplitude at the drawing condition was positively correlated with N400 amplitudes. Thus, the early visual word recognition neural indicator (e.g., N170) was predictive of the late neural indicator of semantic processing (e.g., N400), suggesting that hand movement facilitates the neural correlates between early word recognition and later comprehension.
Visual Perception in Expert Athletes: The Case of Rock Climbers
Authors: Marcen-Cinca Noel , Sanchez Xavier , Otin Sofia , Cimarras-Otal Cristina , Bataller-Cervero Ana Vanessa
Published: July 2022

The purpose of the present study was to examine the visual perception system in expert climbers through a psychophysical optical test in a cross-sectional study. Twenty-seven male participants with an International Rock Climbing Research Association (IRCRA) best on-sight lead skill level ranging between 18 and 27 and a best red-point level ranging between 18 and 29 completed a series of psychophysical optic tests assessing their visual field, visual acuity, and contrast sensitivity. Climbers were divided by their best red-pointed lead level, and, following IRCRA recommendations, two groups were created: an advanced group (IRCRA redpoint level between 18 and 23), and an elite-high elite group (IRCRA redpoint level between 24 and 29). The elite group presented more training days per week (5.25 ± 1.28), best on-sighted lead level (24.63 ± 1.92 IRCRA), and best red-pointed lead level (26.63 ± 2.56 IRCRA) than the advanced group (3.67 ± 0.91 training days per week, 19.50 ± 1.04 IRCRA on-sighted level and 20.67 ± 1.57 IRCRA red-pointed level). Better visual perception outputs were produced by the group of elite climbers in visual field tests; no differences were observed between the two groups for visual acuity and contrast sensitivity tests. Overall, findings indicate that best climbers performed better at the visual perception tasks that tested their visual field. Such better perception from best climbers is discussed given (1) the greater time they spend coercing the visual system during practicing climbing and (2) the specific complexity of the stimuli as they are confronted to harder routes where holds are less perceptible and the time to find best hold sequences is constrained.
Unrevealing the Hidden Effects of Job Insecurity: A Moderated-Mediation Model of Moral Disengagement and Moral Identity
Authors: Zhang Zheng , Waqas Muhammad , Yahya Farzan , Qadri Usman A. , Marfoh Joseph
Published: July 2022

Moral disengagement is an intensely negative reaction that triggers unethical behavior in the workplace. By integrating the conservation of resources and moral disengagement theories, the current research examined how moral disengagement can explain the mechanism through which job insecurity results in adverse consequences. Furthermore, moral identity was theorized to moderate the hypothesized relationships. The theoretical model was tested by using time-lagged multisource data collected from 425 Chinese employees and their respective supervisors associated with the healthcare sector. The study concluded that job insecurity was positively linked with employees’ moral disengagement, which, in turn, led to coworker undermining behavior. Furthermore, moral identity moderated the relationship between job insecurity, moral disengagement, and coworker undermining such that employees high in moral identity experience less moral disengagement and are less involved in coworker undermining. Theoretical and practical implications along with future research avenues are discussed.
Facilitative Effects of Embodied English Instruction in Chinese Children
Authors: Guan Connie Qun , Meng Wanjin
Published: July 2022

Research into the lexical quality of word representations suggests that building a strong sound, form, and meaning association is a crucial first step for vocabulary learning. For children who are learning a second language (L2), explicit instruction on word morphology is generally more focused on whole word, rather than sub-lexical, meaning. Though morphological training is emphasized in first language (L1) vocabulary instruction, it is unknown whether this training facilitates L2 word learning through sub-lexical support. To test this, we designed three experimental learning conditions investigating embodied morphological instruction [i.e., hand writing roots (HR), dragging roots (DR), gesturing roots (GR)] to compare against a control condition. One hundred students were randomly assigned to the four experimental groups. Pre- and post-tests examining knowledge of word meanings, forms, and sounds were administered. Results of mixed linear modeling revealed that three embodied morphological instruction on roots enhanced L2 vocabulary learning. Hand writing roots facilitated sound-meaning integration in all category-tasks for accessibility to word form and one task for word sound-form association. By contrast, GR facilitated meaning-based learning integration in two out of three category tasks for word form-meaning association. Chunking and DR facilitated meaning-based integration in one out of three category tasks for word form-meaning association. These results provide evidence that the underlying embodied morphological training mechanism contributes to L2 vocabulary learning during direct instruction. Future directions and implications are discussed.
The Psychological Impact of Global Education Approach to SDGs. A Study on Emotions and Sustainability Attitudes of European Teachers
Authors: Boffi Marco , Rainisio Nicola , Inghilleri Paolo
Published: July 2022

In line with the international policies, Global Education (GE) programs have been widely spread in European schools over the last 20 years, in order to promote environmental and social sustainability and the achievement of the Sustainable Development Goals. Despite this popularity, their effects on attitudes and behaviors have been poorly investigated so far, particularly for teachers. Our study addressed this research gap analyzing the psychological impact of an extensive GE project involving 1,303 teachers from 10 European countries. Relevant changes in teachers' emotional states and attitudes toward sustainability and migrations were analyzed through a pre-post experimental design. Results showed that the GE activities had wide positive effects on teachers, reducing their negative emotions after teaching, increasing their attitudes about sustainability, and mitigating negative attitudes toward migrants. No significant impacts on positive emotions have been detected. Educational and methodological implications of the applied psychological assessment are finally discussed.
Measuring Immersion, Involvement, and Attention Focusing Tendencies in the Mediated Environment: The Applicability of the Immersive Tendencies Questionnaire
Authors: Rózsa Sándor , Hargitai Rita , Láng András , Osváth Anikó , Hupuczi Ernő , Tamás István , Kállai János
Published: July 2022

This study explores the personal predispositions and dependencies while individuals use digital media and communication devices and analyses the statistical features of the Immersive Tendencies Questionnaire (ITQ) that is popular in assessing the personality trait-dependent reaction to mediated environments. The study evaluated 781 healthy graduates and postgraduates, of which 192 were men (average age: 28.6 years) and 589 were women (average age: 28.4 years). We applied several questionnaires to measure immersive tendencies in a mediated environment, adaptive and maladaptive personality predispositions, and problematic Internet use and Facebook addiction scales. We analyze the statistical features of the long and short forms of the Immersive Tendencies Questionnaire. The data obtained support the reliable usage of the short form of the instrument. The factor structure of the questionnaire presents dual facets. First, it indicates an absorptive and immersive tendency in any case of maladaptive tendencies. Second, it reflects an intensive capability to focus on the mediated environment with adequate cognitive control to avoid any contingency of being addicted. The short form of the ITQ is reliable and adequate to assess the relationship between the self-referred and environment-dependent psychological functions.
The Effect of Social Exclusion on Trust Among Youth Orphaned by HIV/AIDS: Evidence From an Event-Related Potentials Study
Authors: Wan Jiaojiao , Zhao Qi , Zhang Yafei , Ji Lili , Zhao Junfeng , Qiao Shan , Li Xiaoming
Published: July 2022

Grounded in a follow-up study among children who lost one or both parents to HIV in central China in the early 2000s, we conducted an event-related potentials (ERPs) experiment to explore the effect of social exclusion on trust and the corresponding neurophysiological mechanism among youth orphaned by HIV/AIDS (“AIDS orphans”). A sample of 31 AIDS orphans (26.16 ± 3.34 years old; 15 female) and 32 age and development status matched controls (25.02 ± 3.45 years old; 14 female) participated in the study. They were all assigned to play Cyberball, a virtual ball-tossing game that reliably induced social exclusion (15 orphans, 16 controls) and inclusion (16 orphans, 16 controls). Then, they played the Trust Game by taking the role of trustor with their electroencephalograms (EEGs) being recorded during the game. In the Trust Game, each participant was required to decide whether to trust their partners in over 150 trials (decision-making stage). The partner’s reciprocation strategies were pre-programmed by the experimenter (with an overall reciprocating rate of 50%). All participants were provided with post-decision feedback about the outcome of their decisions (gain or loss of game points) in each trial (outcome evaluation stage). We analyzed their behavioral responses at the decision-making stage and ERP components at the outcome evaluation stage. Behavioral results showed that the proportion of orphans choosing trust was significantly higher than the controls, and the trust ratio of the orphan exclusion (OE) group was significantly higher than that of the orphan inclusion (OI) group, control exclusion (CE) group, and control inclusion (CI) group. Furthermore, the response time of the OE group was significantly shorter than that of other groups. ERP results indicated that the amplitude of the feedback-related negativity (FRN) in the OI group was significantly more negative than that in the CI group with loss feedback, while there was no significant difference between the OE and OI groups. Similarly, the P300 amplitudes following outcome feedback were larger in the CI group than that in the OI group with gain feedback and had no significant difference between OE and OI.
Investigating Orthorexia Nervosa With the ORTO-R in a Sample of University Students With or Without Subthreshold Autism Spectrum: Focus on Dietary Habits and Gender Differences
Authors: Dell'Osso Liliana , Cremone Ivan Mirko , Chiarantini Ilaria , Arone Alessandro , Casagrande Danila , Massimetti Gabriele , Carmassi Claudia , Carpita Barbara
Published: July 2022

Background

The aim of the present study was to investigate the presence of Orthorexia (ON) symptoms in a sample of University students with or without autistic traits (AT), specifically focusing on evaluating the role of gender and of dietary habits in the association between ON and autism spectrum.

Methods

Subjects were requested to anonymously fill out the questionnaires through an online form.

Results

Two thousand one hundred forty students participated in the study. Subjects with significant AT, measured by means of the Adult Autism Sub-threshold spectrum (AdAS Spectrum) reported significantly higher ON symptoms, as measured by ORTO-R scores, than subjects with low AT. Females and subjects following a vegetarian/vegan diet reported significantly higher ORTO-R scores than males and than subjects following an omnivorous diet, respectively. Significant positive correlations were found between ORTO-R and AdAS Spectrum scores. A decision tree model, with gender, type of diet and presence of high AT as independent variables and ORTO-R score as dependent variable, showed in the first step the presence of significantly higher ORTO-R scores among females than among males, and in the second step showed in both genders the presence of higher ORTO-R scores among subjects with high AT than in those with low AT. A significant interaction of gender and presence/absence of high AT was reported on ORTO-R score, with a higher increasing trend of ORTO-R score with the increase of AdAS Spectrum score among females than among males.

Conclusions

Our results further highlighted the association between AT and ON, in particular among females.
Feasibility and Potential Effectiveness of a Smartphone Zero-Time Exercise Intervention for Promoting Physical Activity and Fitness in Patients With Coronary Heart Disease: A Pilot Randomized Controlled Trial
Authors: Chan Noel P. T. , Lai Agnes Y. K. , Choy Hau K. , Cheung Derek Y. T. , Wan Alice N. T. , Cheng Victor Y. H. , Chan Ka Y. , Lau Yuk K. , Yung Chi Y. , Cheung George O. C. , Lam T. H.
Published: July 2022

Background

Zero-time Exercise (ZTEx), a simple strength- and stamina-enhancing physical activity (PA) requiring no extra equipment, can potentially increase PA and fitness. This pilot trial examined the feasibility and potential effectiveness of a smartphone ZTEx intervention to promote PA and fitness in patients with coronary heart disease (CHD).

Methods

A parallel-group assessor-blinded pilot randomized controlled trial was conducted on Chinese patients with stable coronary heart disease (CHD) in three cardiology clinics. The experimental group received a 15-min brief individual face-to-face session and a 12-week ZTEx instant messaging with 28 picture e-messages and a smartphone ZTEx application (ZTExApp). The control group received the same duration of individual session and number and format of e-messages, but the content was healthy eating and breathing exercise. The feasibility was assessed based on: attrition rate, usage, response rate and perception of the intervention. The outcome evaluation included primary outcome (PA), fitness, exercise self-efficacy and intention, perceived happiness and health, and quality of life. A linear mixed model was used with intention-to-treat analysis adjusting for sex, age and baseline values. A semi-structured interview was conducted to collect feedback from the experiment group.

Results

One hundred thirty-nine patients (mean age 59.8 ± 6.6; 71.2% male) were randomized to the experimental group (n = 70) or control group (n = 69), and 80% (56/70) and 82% (57/69) of patients completed the 12-week follow-up assessment, respectively. The attrition rate was 18.7%. The experimental group reported that ZTEx was feasible to integrate PA into their daily life and appreciated the picture e-messages, and 95% of them sent feedback to us, but only 19.6% (13/70) of the participants entered their PA information into the e-diary of the ZTExApp. The experimental group had a significantly greater increase in time spent walking [mean difference (95% CI): 155.3 (10.1, 300.4), P = 0.04, Cohen's d = 0.34] than the control group.

Conclusions

This pilot study showed using a brief ZTEx face-to-face session with picture e-messages empowered patients with CHD to integrate PA into daily life. Future definitive trials with a longer follow-up and a more user-friendly ZTExApp interface are necessary to determine the effectiveness of the smartphone ZTEx intervention in enhancing PA and related outcomes.

Trial Registration

The research protocol was registered at the Hong Kong University Clinical Trials Registry (HKUCTR) on 22 Jul 2016 (Study identifier: HKUCTR-2165) and was also retrospectively registered at the National Institutes of Health (identifier number: NCT03464331) on 14 March 2018.
Clinical Efficacy and Safety of Surgical Treatments in Patients With Pure Cervical Radiculopathy
Authors: Gao Quan-You , Wei Fei-Long , Zhu Kai-Long , Zhou Cheng-Pei , Zhang Hu , Cui Wen-Xing , Li Tian , Qian Ji-Xian , Hao Ding-Jun
Published: July 2022

Background

Traditionally paired meta-analysis revealed inconsistencies in the safety and effectiveness of surgical interventions. We conducted a network meta-analysis to assess various treatments' clinical efficacy and safety for pure cervical radiculopathy.

Methods

The Embase, PubMed, and Cochrane Library databases were searched for randomized controlled trials (RCTs) comparing different treatment options for patients with pure cervical radiculopathy from inception until October 23, 2021. The primary outcomes were postoperative success rates, postoperative complication rates, and postoperative reoperation rates. The pooled data were subjected to a random-effects consistency model. The protocol was published in PROSPERO (CRD42021284819).

Results

This study included 23 RCTs (n = 1,844) that evaluated various treatments for patients with pure cervical radiculopathy. There were no statistical differences between treatments in the consistency model in terms of major clinical effectiveness and safety outcomes. Postoperative success rates were higher for anterior cervical foraminotomy (ACF: probability 38%), posterior cervical foraminotomy (PCF: 24%), and anterior cervical discectomy with fusion and additional plating (ACDFP: 21%). Postoperative complication rates ranked from high to low as follows: cervical disc replacement (CDR: probability 32%), physiotherapy (25%), ACF (25%). Autologous bone graft (ABG) had better relief from arm pain (probability 71%) and neck disability (71%). Among the seven surgical interventions with a statistical difference, anterior cervical discectomy with allograft bone graft plus plating (ABGP) had the shortest surgery time.

Conclusions

According to current results, all surgical interventions can achieve satisfactory results, and there are no statistically significant differences. As a result, based on their strengths and patient-related factors, surgeons can exercise discretion in determining the appropriate surgical intervention for pure cervical radiculopathy.

Systematic Review Registration: CRD42021284819.
Does It Matter to Establish a Strategic Partnership for COVID-19 Prevention and Control? The Perspective of Multiple Distances in Emerging Economies
Authors: Zhao Can , Wei Meng-Yang , Chen Yan , Shen Ruo-Yan
Published: July 2022

The rapid spread of the COVID-19 pandemic in early 2020 has impacted the politics, economy and society of countries around the world. The public health diplomacy system through which developed countries in Europe and America used to provide vertical one-way assistance to developing countries faces huge challenges. How emerging economies can cooperate to fight the pandemic on the basis of mutual trust and mutual benefit has become an urgent issue. In this paper, we examine the impact of political mutual trust on the effectiveness of pandemic prevention and control from the perspective of establishing strategic partnerships between emerging economies. Furthermore, taking into account the huge differences between emerging economies, this paper explores institutional distance, cultural distance, and geographical distance—the adjustment effect of the control effect. Studies have shown that the improvement of political mutual trust is conducive to the formation of a community of shared futures between countries and has a positive effect on curbing the spread of the pandemic. The increase of the three-dimensional distance of institutions, culture, and geography will weaken the effect of establishing strategic partners for pandemic prevention and control. This paper explores a new model of horizontal international cooperation among emerging economies, and provides a reference for emerging economies to deal with common globalization issues in the future.