bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Hardware Implementation of an IGBT-Based Half-Bridge Cell for Modular Voltage Source Inverters
Authors: Morales-Caporal Roberto , Pérez-Cuapio José F. , Martínez-Hernández Haydee P. , Cortés-Maldonado Raúl
Published: October 2021

This article presents the design and hardware implementation of an IGBT-based half-bridge voltage source inverter (VSI) to be used as a basic cell to assemble VSIs of different topologies in modular ways. Herein, we have presented the design methodology and utilized techniques for reducing stray inductances and EMI radiation on the printed circuit board, as well as the way to calculate and select the main electronic components. For the design of the circuit board, local regulations for grid interconnection and international standards were considered in order to obtain a safe and reliable electronic power cell. The developed hardware was subjected to different tests using AC electric motors as loads to validate its design. Two VSIs topologies were evaluated: a single-phase two-level full-bridge inverter and a three-phase two-level inverter. The experimental results validated the theory and demonstrated the excellent performance, reliability, and high efficiency of the developed half-bridge power cell for modular VSIs.
An Implementation Design of Unified Protocol Architecture for Physical Layer of LoRaWAN End-Nodes
Authors: Park Jean , Kim Juyeop
Published: October 2021

LoRa Wide Area Networks (LoRaWAN) can provide a connectivity service to Internet of Things (IoT) for an extremely long run-time and with low power consumption. As the LoRaWAN is extensively applied to various IoT scenarios, LoRaWAN solutions face a flexibility issue in terms of inter-operating with various kinds of LoRa modem hardware and protocol scenarios. In this regard, we design a unified protocol architecture for LoRaWAN physical layer, which can flexibly correspond to various deployment and operational cases. The new protocol architecture includes a hardware abstraction sub-layer, which contains generalized handlers for configuring various kinds of the LoRa modem, and a physical procedure sub-layer that structurally models the physical layer procedures of the LoRaWAN based on Finite State Machine(FSM). We illustrate the flexibility of the new protocol architecture by implementing an extensive feature that enhances the packet reception ratio based on the status of preamble detection. For evaluating the new protocol architecture, we implement the LoRaWAN physical layer protocol on real-time embedded systems and conduct experiments. The experimental results show that the proposed protocol robustly transmits and receives packets and generates little amount of additional burden compared with the conventional open source protocol provided by SemTech.
Segmentation of Aorta 3D CT Images Based on 2D Convolutional Neural Networks
Authors: Bonechi Simone , Andreini Paolo , Mecocci Alessandro , Giannelli Nicola , Scarselli Franco , Neri Eugenio , Bianchini Monica , Dimitri Giovanna Maria
Published: October 2021

The automatic segmentation of the aorta can be extremely useful in clinical practice, allowing the diagnosis of numerous pathologies to be sped up, such as aneurysms and dissections, and allowing rapid reconstructive surgery, essential in saving patients’ lives. In recent years, the success of Deep Learning (DL)-based decision support systems has increased their popularity in the medical field. However, their effective application is often limited by the scarcity of training data. In fact, collecting large annotated datasets is usually difficult and expensive, especially in the biomedical domain. In this paper, an automatic method for aortic segmentation, based on 2D convolutional neural networks (CNNs), using 3D CT (computed axial tomography) scans as input is presented. For this purpose, a set of 153 CT images was collected and a semi-automated approach was used to obtain their 3D annotations at the voxel level. Although less accurate, the use of a semi-supervised labeling technique instead of a full supervision proved necessary to obtain enough data in a reasonable amount of time. The 3D volume was analyzed using three 2D segmentation networks, one for each of the three CT views (axial, coronal and sagittal). Two different network architectures, U-Net and LinkNet, were used and compared. The main advantages of the proposed method lie in its ability to work with a reduced number of data even with noisy targets. In addition, analyzing 3D scans based on 2D slices allows for them to be processed even with limited computing power. The results obtained are promising and show that the neural networks employed can provide accurate segmentation of the aorta.
State Estimation in Electric Power Systems Using an Approach Based on a Weighted Least Squares Non-Linear Programming Modeling
Authors: Florez Hugo A. R. , Marujo Diogo , López Gloria P. , López-Lezama Jesús M. , Muñoz-Galeano Nicolás
Published: October 2021

In this work, the state estimation problem of electric power systems is represented through a mathematical programming approach. Initially, a non-linear mathematical model based on the classical method of weighted least squares is proposed to solve the state estimation problem for comparative purposes. Due to the inherent limitations that this classical model presents when dealing with errors in the set of measurements, a new mathematical model is proposed that can be used within an iterative procedure to reduce the impact of measurement errors on the estimated results. Several tests on a didactic 5-bus power system and IEEE benchmark power test systems showed the effectiveness of the proposed approach which achieved better results than the proposed classical state estimation model. The non-linear programming models proposed in this paper are implemented in the mathematical modeling language AMPL. Additionally, to validate the results of the proposed methodologies, the power system operation points are compared with the results obtained using the Matpower simulation package. The results allowed concluding that the proposed mathematical models can be successfully applied to perform state estimation studies in power systems.
Potential Use of Copper-Contaminated Soils for Hemp (Cannabis sativa L.) Cultivation
Authors: Quagliata Giulia , Celletti Silvia , Coppa Eleonora , Mimmo Tanja , Cesco Stefano , Astolfi Stefania
Published: October 2021

To mitigate climate change, reducing greenhouse gas emissions can be achieved by decreasing the use of fossil fuels and increasing that of alternative sources, such as energy crops. However, one of the most important problems in the use of biomass as a fuel is that of changing soil use and consumption, leading to competition with food crops. We addressed the topic by evaluating the possibility to exploit contaminated areas for energy crops cultivation. Indeed, soil contamination makes land inappropriate for cultivation, with damaging consequences for ecosystems, as well as posing serious health hazards to living beings. Specifically, this work aimed to evaluate the ability of hemp (Cannabis sativa L.) plants to grow on a copper (Cu)-contaminated medium. In addition, the effectiveness of an environment-friendly treatment with sulfate in improving plant ability to cope with Cu-induced oxidative stress was also explored. Results showed that plants were able to grow at high Cu concentrations. Therefore, hemp could represent an interesting energy crop in Cu-contaminated soils. Although the response of Cu-treated plants was evidenced by the increase in thiol content, following modulation of sulfur metabolism, it remains to be clarified whether the use of exogenous sulfate could be an agronomic practice to improve crop performance under these edaphic conditions.
The Transport and Evolution of MHD Turbulence throughout the Heliosphere: Models and Observations
Authors: Adhikari Laxman , Zank Gary P. , Zhao Lingling
Published: October 2021

A detailed study of solar wind turbulence throughout the heliosphere in both the upwind and downwind directions is presented. We use an incompressible magnetohydrodynamic (MHD) turbulence model that includes the effects of electrons, the separation of turbulence energy into proton and electron heating, the electron heat flux, and Coulomb collisions between protons and electrons. We derive expressions for the turbulence cascade rate corresponding to the energy in forward and backward propagating modes, the fluctuating kinetic and magnetic energy, the normalized cross-helicity, and the normalized residual energy, and calculate the turbulence cascade rate from 0.17 to 75 au in the upwind and downwind directions. Finally, we use the turbulence transport models to derive cosmic ray (CR) parallel and perpendicular mean free paths (mfps) in the upwind and downwind heliocentric directions. We find that turbulence in the upwind and downwind directions is different, in part because of the asymmetric distribution of new born pickup ions in the two directions, which results in the CR mfps being different in the two directions. This is important for models that describe the modulation of cosmic rays by the solar wind.
Experimental Characterization of the Flow Field around Oblong Bridge Piers
Authors: Bento Ana Margarida , Viseu Teresa , Pêgo João Pedro , Couto Lúcia
Published: October 2021

The prediction of scour evolution at bridge foundations is of utmost importance for engineering design and infrastructures’ safety. The complexity of the scouring inherent flow field is the result of separation and generation of multiple vortices and further magnified due to the dynamic interaction between the flow and the movable bed throughout the development of a scour hole. In experimental environments, the current approaches for scour characterization rely mainly on measurements of the evolution of movable beds rather than on flow field characterization. This paper investigates the turbulent flow field around oblong bridge pier models in a well-controlled laboratory environment, for understanding the mechanisms of flow responsible for current-induced scour. This study was based on an experimental campaign planned for velocity measurements of the flow around oblong bridge pier models, of different widths, carried out in a large-scale tilting flume. Measurements of stream-wise, cross-wise and vertical velocity distributions, as well as of the Reynolds shear stresses, were performed at both the flat and eroded bed stages of scouring development with a high-resolution acoustic velocimeter. The time-averaged values of velocity and shear stress are larger in the presence of a developed scour hole than in the corresponding flat bed configuration.
Consumer Trust in Food and the Food System: A Critical Review
Authors: Wu Wen , Zhang Airong , van Klinken Rieks Dekker , Schrobback Peggy , Muller Jane Marie
Published: October 2021

Increased focus towards food safety and quality is reshaping food purchasing decisions around the world. Although some food attributes are visible, many of the attributes that consumers seek and are willing to pay a price premium for are not. Consequently, consumers rely on trusted cues and information to help them verify the food quality and credence attributes they seek. In this study, we synthesise the findings from previous research to generate a framework illustrating the key trust influencing factors that are beyond visual and brand-related cues. Our framework identifies that consumer trust in food and the food system is established through the assurances related to individual food products and the actors of the food system. Specifically, product assurance builds consumer trust through food packaging labels communicating food attribute claims, certifications, country or region of origin, and food traceability information. In addition, producers, processors, and retailers provide consumers with food safety and quality assurances, while government agencies, third-party institutions, advocacy groups, and the mass media may modify how labelling information and food operators are perceived by consumers. We hope our framework will guide future research efforts to test these trust factors in various consumer and market settings.
The Fading Wild Plant Food–Medicines in Upper Chitral, NW Pakistan
Authors: Abdul Aziz Muhammad , Ullah Zahid , Adnan Muhammad , Sõukand Renata , Pieroni Andrea
Published: October 2021

The subject of food–medicines (foods ingested in order to obtain a therapeutic activity or to prevent diseases) is garnering increasing attention from both ethnobiologists and ethnopharmacologists as diet-related chronic diseases are one of the major problems resulting in a large proportion of deaths globally, which calls for interest from the scientific community to make sensible decisions in the field of food and medicine. In this regard, the current study is an important attempt at providing baseline data for developing healthy and curative food ingredients. This study aimed at recording the culinary and medicinal uses of wild food plants (WFPs) in the remote Mastuj Valley, located at the extreme north of Chitral District, Pakistan. An ethnobotanical survey was completed via 30 in-depth semi-structured interviews with local knowledge holders to record the food and medicinal uses of WFPs in the study area. A total of 43 WFPs were recorded, most of which were used as cooked vegetables and raw snacks. Leaves were the most frequently used plant part. A remarkable proportion (81%) of use reports for the recorded wild plant taxa were quoted as food–medicines or medicinal foods, while very few were reported as either food or medicines, without any relationship between uses in these two domains. Previous ethnomedicinal studies from nearby regions have shown that most of the recorded wild plants have been used as medicines, thus supporting the findings of the current study. A literature survey revealed that many of the reported medicinal uses (33%) for the quoted WFPs were not verifiable on PubMed as they have not been studied for their respective medicinal actions. We observed that most of the plants quoted here have disappeared from the traditional food and medicinal system, which may be attributed to the invasion of the food market and the prevalence of allopathic medicine. However, knowledge of these wild plants is still alive in memory, and women are the main holders of cultural knowledge as they use it to manage the cooking and processing of WFPs. Therefore, in this context, we strongly recommend the preservation of local biocultural heritage, promoted through future development and educational programs, which could represent a timely response to the loss of cultural and traditional knowledge.
Low Acrylamide Flatbreads from Colored Corn and Other Flours
Authors: Li Xueqi , Kahlon Talwinder , Wang Selina C. , Friedman Mendel
Published: October 2021

Dietary acrylamide formed during baking and frying of plant-based foods such as bread and other cereal products, coffee, fried potatoes, and olives is reported to induce genotoxic, carcinogenic, neurotoxic, and antifertility properties in vivo, suggesting the need to keep the acrylamide content low with respect to widely consumed heat-processed food including flatbreads. Due to the fact that pigmented corn flours contain biologically active and health-promoting phenolic and anthocyanin compounds, the objective of this study was to potentially define beneficial properties of flatbread by evaluating the acrylamide content determined by high-performance liquid chromatography/mass spectrometry (HPLC/MS) with a detection limit of 1.8 µg/kg and proximate composition by standard methods of six experimental flatbreads made from two white, two blue, one red, and one yellow corn flours obtained by milling commercial seeds. Acrylamide content was also determined in experimental flatbreads made from combinations in quinoa flour, wheat flour, and peanut meal with added broccoli or beet vegetables and of commercial flatbreads including tortillas and wraps. Proximate analysis of flatbreads showed significant differences in protein and fat but not in carbohydrate, mineral, and water content. The acrylamide content of 16 evaluated flatbreads ranged from 0 to 49.1 µg/kg, suggesting that these flatbreads have the potential to serve as low-acrylamide functional foods. The dietary significance of the results is discussed.
Physico-Chemical Characteristics and Lipid Oxidative Stability of Zebra (Equus Burchelli) Droëwors Made Using Different Levels of Sheep Fat
Authors: Mandela Zikhona , Arnaud Elodie , Hoffman Louwrens C.
Published: October 2021

The physico-chemical properties (proximate, salt content, water activity (aw), pH) and lipid oxidation of droëwors (dried salted/spiced meat sausages) produced with zebra meat and different sheep fat levels (10, 15, and 20% by weight) measured at day 0 (before drying), day 2 (after drying at 30 °C and 40% relative humidity), and over a 90 day storage (day 17, 32, 47, 62, 77, and 92) under vacuum at 25 °C were investigated. The use of lower fat levels (10 and 15%) in the formulation resulted in higher weight loss during drying and droëwors with higher protein, ash, and salt content and lower aw and pH compared to the droëwors made with 20% fat. The pH increased (p < 0.001) during storage for all the fat levels, while the moisture content and the aw were stable as expected. TBARS values were the highest in droëwors made with 20% of fat after drying (day 2), but droëwors made with 10% of fat reached similar maximal values on day 17. Formulations containing 15% sheep fat displayed the lowest TBARS values after drying and along storage, and thus had the best characteristics in relation to oxidative stability.
Techniques for Dealcoholization of Wines: Their Impact on Wine Phenolic Composition, Volatile Composition, and Sensory Characteristics
Authors: Sam Faisal Eudes , Ma Teng-Zhen , Salifu Rafia , Wang Jing , Jiang Yu-Mei , Zhang Bo , Han Shun-Yu
Published: October 2021

The attention of some winemakers and researchers over the past years has been drawn towards the partial or total dealcoholization of wines and alcoholic beverages due to trends in wine styles, and the effect of climate change on wine alcohol content. To achieve this, different techniques have been used at the various stages of winemaking, among which the physical dealcoholization techniques, particularly membrane separation (nanofiltration, reverse osmosis, evaporative perstraction, and pervaporation) and thermal distillation (vacuum distillation and spinning cone column), have shown promising results and hence are being used for commercial production. However, the removal of alcohol by these techniques can cause changes in color and losses of desirable volatile aroma compounds, which can subsequently affect the sensory quality and acceptability of the wine by consumers. Aside from the removal of ethanol, other factors such as the ethanol concentration, the kind of alcohol removal technique, the retention properties of the wine non-volatile matrix, and the chemical-physical properties of the aroma compounds can influence changes in the wine sensory quality during dealcoholization. This review highlights and summarizes some of the techniques for wine dealcoholization and their impact on wine quality to help winemakers in choosing the best technique to limit adverse effects in dealcoholized wines and to help meet the needs and acceptance among different targeted consumers such as younger people, pregnant women, drivers, and teetotalers.
In Vivo and In Vitro Starch Digestibility of Fresh Pasta Produced Using Semolina-Based or Wholemeal Semolina-Based Liquid Sourdough
Authors: Fois Simonetta , Piu Piero Pasqualino , Sanna Manuela , Roggio Tonina , Catzeddu Pasquale
Published: October 2021

The use of wholemeal flour and sourdough fermentation in different food matrices has received considerable attention in recent years due to its resulting health benefits. In this study, a semolina-based and a wholemeal semolina-based sourdough were prepared and added to the formulation of gnocchetti-type fresh pasta. Four types of gnocchetti were made, using semolina plus semolina-based sourdough (SS), semolina plus wholemeal semolina-based sourdough (SWS), semolina alone (S), and semolina plus wholemeal semolina (WS). The latter two were used as controls. The digestibility of starch was studied both in vitro and in vivo, and the glycemic response (GR) and glycemic load (GL) were determined. Starch digestibility, both in vivo and in vitro, was higher in wholemeal semolina than semolina pasta and the resulting GR values (mg dL−1 min−1) were also higher (2209 and 2277 for WS and SWS; 1584 and 1553 for S and SS, respectively). The use of sourdough significantly reduced the rapidly digestible starch (RDS) content and increased the inaccessible digestible starch (IDS) content. The addition of sourdough to the formulation had no effect on the GR values, but led to a reduction of the GL of the pasta. These are the first data on the GR and GL of fresh pasta made with sourdough.
Effects of Shoe Midsole Hardness on Lower Extremity Biomechanics during Jump Rope in Healthy Males
Authors: Yu Hai-Bin , Tai Wei-Hsun , Li Jing , Zhang Rui , Hao Wei-Ya , Lin Jian-Zhi
Published: October 2021

This study investigated differences in lower extremity muscle activations and vertical stiffness during a 2.2 Hz jump rope exercise with different midsole hardnesses (45, 50, 55, and 60 Shores C). Twelve healthy male participants wore customized shoes with different hardness midsoles and performed jump rope exercises in a random order. A nine-camera motion analysis system (150 Hz), a force platform (1500 Hz), and a wireless electromyography (EMG) system (Noraxon, 1500 Hz) were used to measure the biomechanical parameters during the jump rope exercise. The biceps femoris %MVC of barefoot participants was significantly greater than that of those wearing the 45 Shores C (p = 0.048) and 55 Shores C (p = 0.009) midsole 100 ms before landing. The vastus medialis %MVC of barefoot participants was significantly greater than that of those wearing the 55 C midsole (p = 0.005). Nonsignificant differences in vertical stiffness were found between midsole hardnesses and barefoot. Lower extremity muscle activation differed between conditions. The results of this study indicate that for repetitive activities that entail multiple impacts, sports shoes with a low midsole hardness (e.g., 50 Shores C or 45 Shores C) may be appropriate. It is important to provide customers with information regarding midsole hardness in shoe product labeling so that they properly consider the function of the shoes.
Clinical Outcomes of Genotype-Matched Therapy for Recurrent Gynecological Cancers: A Single Institutional Experience
Authors: Sawada Kiyoka , Nakayama Kentaro , Nakamura Kohei , Yoshimura Yuki , Razia Sultana , Ishikawa Masako , Yamashita Hitomi , Ishibashi Tomoka , Sato Seiya , Kyo Satoru
Published: October 2021

Recent advances in next-generation sequencing and genome medicine have contributed to treatment decisions in patients with cancer. Most advanced gynecological cancers develop resistance to chemotherapy and have a poor prognosis. Therefore, we conducted genomic tests in gynecological tumors to examine the efficacy and clinical feasibility of genotype-matched therapy. Target sequencing was performed in 20 cases of gynecological cancers (cervical cancer, 6; endometrial cancer, 6; and ovarian cancer, 6). Both actionable and druggable genes were identified in 95% (19/20) of the cases. Among them, seven patients (35%) received genotype-matched therapy, which was effective in three patients. Of the three patients, one patient with a PTEN mutation received everolimus, another patient with a TSC2 mutation received everolimus and letrozole, and the patient with a BRIP1 mutation received olaparib. Subsequently, disease control in these three patients lasted for more than half a year. However, all patients relapsed between 9 and 13 months after the initiation of genotype-matched therapy. In this study, the response rate of genotype-matched therapy was 43% (3/7), which may have contributed to improved prognoses. Therefore, genotype-matched therapies may help patients with refractory gynecological cancers achieve better outcomes.
Self-Reported Prevalence of HIV Infection, Sexually Transmitted Infections and Risky Sexual Behavior among Mental Health Care Users Accessing Healthcare Services in Tshwane District, South Africa
Authors: Mokgatle Mathildah Mpata
Published: October 2021

The rate of HIV and sexually transmitted infections among mental patients is higher than that of the general population worldwide. Many risky sexual behaviors are associated with mental illness. However, mental health care users (MHCUs) are not specifically targeted for HIV preventative care, and routine HIV testing is not done among this population. Limited studies have investigated self-reported HIV and STI prevalence and associated risky sexual behavior in persons with mental illnesses accessing health care services in South Africa in particular. This study set out to determine both the Sexually Transmitted Infections (STI) and human immunodeficiency virus (HIV) self-reported prevalence and sexual practices of MHCUs. A descriptive cross-sectional survey using purposive sampling was used to select 107 MHCUs across five clinics within Gauteng Province of South Africa who were above the age of 18, had a mental illness, and were currently stable and receiving chronic medication. Descriptive statistics were performed using Stata IC version 16. The chi square test was used to indicate statistical significance (p < 0.05) of differences in frequency distributions. More males (52.5%) than females were currently in a sexual relationship (50.0%), having multiple sexual partners (n = 4.13%), and having alcohol-driven sex (n = 4.19%). The majority of MHCUs (n = 82.77%) had an STI in the past six months, and a quarter (n = 21.25%) were HIV-positive with over two-thirds of MHCU (n = 69.70%) perceiving themselves not at risk for HIV. MHCUs engaged in risky behaviors had a low perception of the risks of contracting HIV. Bivariate analysis of gender by sexual behavior revealed that female MHCUs are more at risk of being forced to have sex compared to males (p = 0.006). Integrated interventions should be put in place to ensure that MHCUs’ sexual and reproductive health are not left behind and issues such as sexual education, safe sex, and sexually transmitted infections should form part of the care of MHCUs.
Impact of Drought and Flooding on Alkaloid Production in Annona crassiflora Mart
Authors: Honório Ana Beatriz Marques , De-la-Cruz-Chacón Iván , Martínez-Vázquez Mariano , da Silva Magali Ribeiro , Campos Felipe Girotto , Martin Bruna Cavinatti , da Silva Gustavo Cabral , Fernandes Boaro Carmen Sílvia , Ferreira Gisela
Published: October 2021

The Brazilian Cerrado is the second largest Brazilian biome. In recent decades, a reduction in rainfall has indicated an extension of the dry season. Among the many native species of the Cerrado of the Annonaceae family and used in folk medicine, Annona crassiflora Mart. has fruits of high nutritional value and its by-products are sources of bioactive compounds, such as alkaloids. The aim of the study was to investigate how water stress impacts the production of alkaloids. The study was carried out in a nursery, and the knowledge was flood, field capacity and drought. Gas exchange, chlorophyll a fluorescence, antioxidant enzymes, total soluble sugars, starch, reducing sugars, sucrose, total alkaloids and liriodenine were analyzed. We observed that plants subjected to drought had an increase in the production of total alkaloids and liriodenine, without a reduction in photosynthetic metabolism. Plants kept under drought and flood conditions dissipated higher peroxidase activity, while catalase was higher in flooded plants. Starch showed the highest concentration in flooding plants without differing from drought plants; the lowest trehalose concentrations were found in both drought and flooding plants. The drought stimulated the synthesis of total alkaloids and liriodenine without reducing the primary metabolism, which suggests adaptation to Cerrado conditions.
On Information Orders on Metric Spaces
Authors: Otafudu Oliver Olela , Valero Oscar
Published: October 2021

Information orders play a central role in the mathematical foundations of Computer Science. Concretely, they are a suitable tool to describe processes in which the information increases successively in each step of the computation. In order to provide numerical quantifications of the amount of information in the aforementioned processes, S.G. Matthews introduced the notions of partial metric and Scott-like topology. The success of partial metrics is given mainly by two facts. On the one hand, they can induce the so-called specialization partial order, which is able to encode the existing order structure in many examples of spaces that arise in a natural way in Computer Science. On the other hand, their associated topology is Scott-like when the partial metric space is complete and, thus, it is able to describe the aforementioned increasing information processes in such a way that the supremum of the sequence always exists and captures the amount of information, measured by the partial metric; it also contains no information other than that which may be derived from the members of the sequence. R. Heckmann showed that the method to induce the partial order associated with a partial metric could be retrieved as a particular case of a celebrated method for generating partial orders through metrics and non-negative real-valued functions. Motivated by this fact, we explore this general method from an information orders theory viewpoint. Specifically, we show that such a method captures the essence of information orders in such a way that the function under consideration is able to quantify the amount of information and, in addition, its measurement can be used to distinguish maximal elements. Moreover, we show that this method for endowing a metric space with a partial order can also be applied to partial metric spaces in order to generate new partial orders different from the specialization one. Furthermore, we show that given a complete metric space and an inf-continuous function, the partially ordered set induced by this general method enjoys rich properties. Concretely, we will show not only its order-completeness but the directed-completeness and, in addition, that the topology induced by the metric is Scott-like. Therefore, such a mathematical structure could be used for developing metric-based tools for modeling increasing information processes in Computer Science. As a particular case of our new results, we retrieve, for a complete partial metric space, the above-explained celebrated fact about the Scott-like character of the associated topology and, in addition, that the induced partial ordered set is directed-complete and not only order-complete.
File System Support for Privacy-Preserving Analysis and Forensics in Low-Bandwidth Edge Environments
Authors: Ovesen Aril Bernhard , Nordmo Tor-Arne Schmidt , Johansen Håvard Dagenborg , Riegler Michael Alexander , Halvorsen Pål , Johansen Dag
Published: October 2021

In this paper, we present initial results from our distributed edge systems research in the domain of sustainable harvesting of common good resources in the Arctic Ocean. Specifically, we are developing a digital platform for real-time privacy-preserving sustainability management in the domain of commercial fishery surveillance operations. This is in response to potentially privacy-infringing mandates from some governments to combat overfishing and other sustainability challenges. Our approach is to deploy sensory devices and distributed artificial intelligence algorithms on mobile, offshore fishing vessels and at mainland central control centers. To facilitate this, we need a novel data plane supporting efficient, available, secure, tamper-proof, and compliant data management in this weakly connected offshore environment. We have built our first prototype of Dorvu, a novel distributed file system in this context. Our devised architecture, the design trade-offs among conflicting properties, and our initial experiences are further detailed in this paper.
Towards Edge Computing Using Early-Exit Convolutional Neural Networks
Authors: Pacheco Roberto G. , Bochie Kaylani , Gilbert Mateus S. , Couto Rodrigo S. , Campista Miguel Elias M.
Published: October 2021

In computer vision applications, mobile devices can transfer the inference of Convolutional Neural Networks (CNNs) to the cloud due to their computational restrictions. Nevertheless, besides introducing more network load concerning the cloud, this approach can make unfeasible applications that require low latency. A possible solution is to use CNNs with early exits at the network edge. These CNNs can pre-classify part of the samples in the intermediate layers based on a confidence criterion. Hence, the device sends to the cloud only samples that have not been satisfactorily classified. This work evaluates the performance of these CNNs at the computational edge, considering an object detection application. For this, we employ a MobiletNetV2 with early exits. The experiments show that the early classification can reduce the data load and the inference time without imposing losses to the application performance.
Stability of Shield-Bored Tunnel for the Challenge of Nile Crossing
Authors: Elgamal Ahmed , Elfaris Nissreen
Published: October 2021

Underwater tunnel structures are vital in urban areas, and their use is continuously increasing. The engineering assessments for these impressive phenomena have to be performed from both geotechnical and structural engineering perspectives. The designer should take account of the requirements of the underwater structures to adequately withstand different applied loads. The underwater tunnel might be particularly vulnerable at locations where the geological conditions are uncertain. This study will cover all aspects concerning the stability of the tunnel crossing of the River Nile. The protentional exists for the tunnel failure during construction due to insufficient cover thickness and after construction due to a combination of long-term degradation and local scour. There were no imposed constraints on the alignment and the original design with a cover between the tunnel crown and the riverbed of at least one tunnel diameter. The tunnel stability was analyzed based on the most critical underwater section with a minimum cover thickness of the Greater Cairo Metro, Line 2 as the case study. Then, three-dimensional (3D) numerical analysis based on the Finite Element (F.E.) models was employed to explore soil–tunnel interactions. Comparison between numerical models’ results indicated that the safe cover thickness was equal to the tunnel diameter. The minimum cover thickness can be used to verify the required factor of safety calculated by theoretical analysis. The safety factor of the tunnel stability should not be less than 1.5 for construction and service stages and 1.3 for the exceptional case; scour accrues.
Air Temperature and Humidity at the Bottom of Desert Wolf Spider Burrows Are Not Affected by Surface Conditions
Authors: Steves Irene , Berliner Pedro , Pinshow Berry
Published: October 2021

Burrows are animal-built structures that can buffer their occupants against the vagaries of the weather and provide protection from predators. We investigated whether the trapdoors of wolf spider (Lycosa sp.; temporary working name "L. hyraculus") burrows in the Negev Desert serve to maintain favorable environmental conditions within the burrow by removing trapdoors and monitoring the ensuing temperature and relative humidity regime within them. We also monitored the behavioral responses of “L. hyraculus” to trapdoor removal at different times of the day and in different seasons. “L. hyraculus” often spun silk mesh in their burrow entrances in response to trapdoor removal during the day, possibly to deter diurnal predators. The frequency of web-spinning peaked on summer mornings, but spiders began spinning webs sooner after trapdoor removal later in the day. In addition, we monitored temperature and relative humidity in artificial burrows in the summer during the morning and at midday. At noon, air temperature (Ta) at the bottom of open burrows increased by <1 °C more than in covered burrows, but water vapor pressure in burrows did not change. The relatively small increase in Ta in uncovered burrows at midday can probably be ascribed to the penetration of direct solar radiation. Thus, air temperature and humidity at the bottom of the burrow are apparently decoupled from airflow at the surface.
The Effects of Nosema apis and Nosema ceranae Infection on Survival and Phenoloxidase Gene Expression in Galleria mellonella (Lepidoptera: Galleriidae) Compared to Apis mellifera
Authors: Özgör Erkay
Published: October 2021

The study aims to prove the possibility of colonization of N. apis and N. ceranae to the intestine of the greater wax moth, detect the differences of greater wax moth based on the presence of Nosema species and examine the effect of Nosema species on the phenoloxidase level of greater wax moth compared with honeybees. Each group was fed on the 1st day of the experiment with its appropriate diet containing 106 Nosema spores per insect. Each group was checked daily, and dead insects were counted. Furthermore, changes in the level of expression of the phenoloxidase-related gene after Nosema spp. treatment on the 6th, 9th and 12th days, which was detected by Q-PCR, and the mRNA level of phenoloxidase gene were measured in all experiment groups with the CFX Connect Real-Time PCR Detection System. This study shows that Apis mellifera L. has a 66.7% mortality rate in mixed Nosema infections, a 50% mortality rate in N. ceranae infection, a 40% mortality rate in N. apis infection, while there is no death in G. mellonella. A significant difference was found in the mixed Nosema infection group compared to the single Nosema infection groups by means of A. mellifera and G. mellonella (Duncan, p < 0.05). G. mellonella histopathology also shows that Nosema spores multiply in the epithelial cells of greater wax moth without causing any death. The increase in the mRNA level of Phenoloxidase gene in A. mellifera was detected (Kruskal–Wallis, p < 0.05), while the mRNA level of the Phenoloxidase gene did not change in G. mellonella (Kruskal–Wallis, p > 0.05). These findings prove that the Nosema species can colonize into the greater wax moth, which contributes to the dissemination of these Nosema species between beehives.
Comparison of Preoperative Cone-Beam Computed Tomography and 3D-Double Echo Steady-State MRI in Third Molar Surgery
Authors: Valdec Silvio , Al-Haj Husain Adib , Winklhofer Sebastian , Müller Marcel , Piccirelli Marco , Stadlinger Bernd
Published: October 2021

We investigated the reliability of assessing a positional relationship between the inferior alveolar nerve (IAN) and mandibular third molar (MTM) based on CBCT, 3D-DESS MRI, and CBCT/MRI image fusion. Furthermore, we evaluated qualitative parameters such as inflammatory processes and imaging fusion patterns. Therefore, two raters prospectively assessed in 19 patients with high-risk MTM surgery cases several parameters for technical image quality and diagnostic ability using modified Likert rating scales. Inter- and intra-reader agreement was evaluated by performing weighted kappa analysis. The inter- and intra-reader agreement for the positional relationship was moderate (κ = 0.566, κ = 0.577). Regarding the detectability of inflammatory processes, the agreement was substantial (κ = 0.66, κ = 0.668), with MRI providing a superior diagnostic benefit regarding early inflammation detection. Independent of the readers’ experience, the agreement of judgment in 3D-DESS MRI was adequate. Black bone MRI sequences such as 3D-DESS MRI providing highly confidential preoperative assessment in MTM surgery have no significant limitations in diagnostic information. With improved cost and time efficiency, dental MRI has the potential to establish itself as a valid alternative in high-risk cases compared to CBCT in future clinical routine.
Incidence and Transition of Acute Kidney Injury, Acute Kidney Disease to Chronic Kidney Disease after Acute Type A Aortic Dissection Surgery
Authors: Chang Chih-Hsiang , Chen Shao-Wei , Chen Jia-Jin , Chan Yi-Hsin , Yen Chieh-Li , Lee Tao Han , Cheng Yu-Ting
Published: October 2021

Acute kidney disease (AKD) is the persistence of renal injury between days 8 and 90 after an initial acute kidney injury (AKI). In this study, we aimed to explore the incidence of AKD, the association between AKD, and patient outcomes after acute type A aortic dissection (type A AAD) surgery. We identified 696 participants who underwent type A AAD surgery. Patients were categorized into stages 1 to 3 or 0 (non-AKD) AKD groups. Outcomes included major adverse kidney events (MAKEs), respiratory failure, all-cause readmission, and ischemic stroke from day 91 after operation. A total of 376 (54%) participants developed AKI, and 135/376 (35.9%) developed AKD. Moreover, 34/320 (10.6%) patients without AKI still developed AKD. Overall, 169/696 (24.3%) participants developed AKD. Patients with stages 2 and 3 AKD are associated with persisted declined renal function within 1 year. AKD was associated with a higher risk of MAKEs (hazard ratio (HR): 2.52, 95% confidence interval (CI) 1.90–3.33) and all-cause readmission (HR: 2.86, 95% CI: 2.10–3.89). Development of AKD with or without AKI is associated with a higher risk of MAKEs and hospitalization after acute aortic dissection surgery. Higher-stage AKD is associated with a trend of persistent decline in kidney function.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview
Authors: Deumer Undine-Sophie , Varesi Angelica , Floris Valentina , Savioli Gabriele , Mantovani Elisa , López-Carrasco Paulina , Rosati Gian Marco , Prasad Sakshi , Ricevuti Giovanni
Published: October 2021

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic systemic disease that manifests via various symptoms such as chronic fatigue, post-exertional malaise, and cognitive impairment described as “brain fog”. These symptoms often prevent patients from keeping up their pre-disease onset lifestyle, as extended periods of physical or mental activity become almost impossible. However, the disease presents heterogeneously with varying severity across patients. Therefore, consensus criteria have been designed to provide a diagnosis based on symptoms. To date, no biomarker-based tests or diagnoses are available, since the molecular changes observed also largely differ from patient to patient. In this review, we discuss the infectious, genetic, and hormonal components that may be involved in CFS pathogenesis, we scrutinize the role of gut microbiota in disease progression, we highlight the potential of non-coding RNA (ncRNA) for the development of diagnostic tools and briefly mention the possibility of SARS-CoV-2 infection causing CFS.
Minimally Invasive Surgery and Surgical Volume-Specific Survival and Perioperative Outcome: Unmet Need for Evidence in Gynecologic Malignancy
Authors: Matsuzaki Shinya , Klar Maximilian , Chang Erica J. , Matsuzaki Satoko , Maeda Michihide , Zhang Renee H. , Roman Lynda D. , Matsuo Koji
Published: October 2021

This study examined the effect of hospital surgical volume on oncologic outcomes in minimally invasive surgery (MIS) for gynecologic malignancies. The objectives were to assess survival outcomes related to hospital surgical volume and to evaluate perioperative outcomes and examine non-gynecologic malignancies. Literature available from the PubMed, Scopus, and the Cochrane Library databases were systematically reviewed. All surgical procedures including gynecologic surgery with hospital surgical volume information were eligible for analysis. Twenty-three studies met the inclusion criteria, and nine gastro-intestinal studies, seven genitourinary studies, four gynecological studies, two hepatobiliary studies, and one thoracic study were reviewed. Of those, 11 showed a positive volume–outcome association for perioperative outcomes. A study on MIS for ovarian cancer reported lower surgical morbidity in high-volume centers. Two studies were on endometrial cancer, of which one showed lower treatment costs in high-volume centers and the other showed no association with perioperative morbidity. Another study examined robotic-assisted radical hysterectomy for cervical cancer and found no volume–outcome association for surgical morbidity. There were no gynecologic studies examining the association between hospital surgical volume and oncologic outcomes in MIS. The volume–outcome association for oncologic outcome in gynecologic MIS is understudied. This lack of evidence calls for further studies to address this knowledge gap.
Lack of Association between Serum Interleukin-23 and Interleukin-27 Levels and Disease Activity in Patients with Active Systemic Lupus Erythematosus
Authors: Pawlak-Buś Katarzyna , Schmidt Wiktor , Leszczyński Piotr
Published: October 2021

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of multiple autoantibodies, resulting in tissue and organ damage. Recent studies have revealed that interleukin-23 (IL-23) and interleukin-27 (IL-27) may be therapeutically relevant in selected SLE manifestations. This study aimed to identify associations between serum IL-27 and IL-23 levels and disease activity in Polish patients with different manifestations of SLE: neuropsychiatric lupus (NPSLE), and lupus nephritis (LN). Associations between interleukin levels and oligo-specific antibodies against double-stranded DNA (dsDNA), dose of glucocorticoids, and type of treatment were also analyzed. An enzyme-linked immunosorbent assay was used to assess anti-dsDNA antibodies and analyze the serum concentration of IL-27 and IL-23 from 72 patients aged 19–74 years with confirmed active SLE. Disease activity was measured using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI 2-K). No significant correlations between interleukin levels and SLEDAI score, anti-dsDNA, corticosteroid dose, or type of treatment were noted. Patients with NPSLE and LN presented the highest median scores of SLEDAI.