bluuebunny/crossref_metadata_2025 huggingface dataset:
Confesiones inconfesables. La infancia recuperada en dos poemas de Jaime Gil de Biedma
Authors: Chirinos Arrieta Eduardo
Published: April 2023

En numerosas páginas ensayísticas y autobiográficas Jaime Gil de Biedma se ha detenido a reflexionar sobre el estrecho vínculo que existe entre la poesía y la sensibilidad infantil. Para un lector más o menos familiarizado con su obra no será difícil encontrar en estas reflexiones paráfrasis de poemas (incluso prosificación de versos y estrofas) que funcionan como claves de lectura. En el ensayo titulado precisamente «Sensibilidad infantil, mentalidad adulta» (1980), Gil de Biedma explica que la unificación de la sensibilidad solo es posible en el reencuentro voluntario con la infancia, la misma que a lo largo de los años se ha visto fragmentada por el desarrollo de la conciencia con ayuda de la educación formal.
Dinámicas sociales y contexto institucional en los centros educativos
Authors: Dupriez Vincent
Published: April 2023

Para este análisis me serviré de algunas herramientas teóricas, útiles porque per, miten el diálogo entre las personas. Y o puedo comunicarme de manera más eficaz con otro docente, con otro director de escuela, con otro investigador, entender su reali, dad mucho más fácilmente, si manejamos conceptos comunes y compartimos las for, mas de cualificar y de identificar los fenómenos. Desde luego, en este tipo de semina, rios, hay mucho interés en aclarar los conceptos con los cuales estamos trabajando.
El difícil cambio en los procesos de enseñanza, aprendizaje en escuelas vulnerables chilenas
Authors: Román Marcela
Published: April 2023

El artículo trabaja sobre un conjunto de estudios cualitativos realizados en esta, blecimientos vulnerables urbano,marginales y rurales, para describir y analizar la efectividad de la práctica pedagógica desarrollada por los docentes en la sala de clase, en relación a las representaciones sociales que ellos construyen sobre sus alumnos y alum, nas. En este contexto, se analiza y discute factores y variables referidos al universo simbólico de los docentes, que están mediando y afectando la calidad del proceso de enseñanza,aprendizaje que profesores y profesoras conducen e instalan en el aula es, colar en dichos contextos.
Los Objetivos Fundamentales Transversales de la reforma chilena. Reflexiones desde la práctica
Authors: Córdoba C. Claudia.
Published: April 2023

Acuerdos internacionales destacan la necesidad de que el sistema educativo incor, pore dentro de su quehacer cotidiano el desarrollo de habilidades personales, socia, les y afectivas en sus alumnos y alumnas. De esta forma lo que actualmente se pro, mueve es un cambio en la orientación del proceso educativo, asumiendo que las políticas educacionales exitosas son aquellas en que «el sistema educativo se hace parte en la formación de valores, estimula el desarrollo del carácter, enseña a traba, jar en equipo y a usar la iniciativa personal, y crea las bases para una convivencia res, ponsable y disciplinada, y no se preocupa solo del desarrollo cognitivo de los alum, nos» (Presidencia de la República 1995).
Liderazgo que promueve liderazgos
Authors: Anglas Cárpena Alina Otilia
Published: April 2023

El presente artículo consta de dos partes: una primera se contextualiza abor, dando el capítulo de Fe y Alegría en la educación del Perú, definiéndola, caracteri, zando su rol, así como delineando su modelo de organización y gestión. En un se, gundo capítulo se desarrolla el tema del liderazgo en Fe y Alegría, analizando el caso de una escuela, donde se hace una mirada rápida del contexto, un esbozo del modelo de organización y gestión, los actores y los liderazgos que ellos asumen en el ámbito educativo.
¿La escuela educa para la democracia o para el autoritarismo?
Authors: Evans Elizabeth
Published: April 2023

Para iniciar, se señala algunos rasgos típicos de sociedades con un fuerte control au, toritario, que bordean la dictadura; deducibles de la década pasada vivida en el Perú bajo un régimen que llegó a controlar casi la totalidad de las instituciones del Estado y de la sociedad civil. Se compara tal situación con el proceso de construcción demo, crática que ahora se está viviendo. Aunque estas características no se dan de manera estática y categórica en un mo, mento específico, pues se producen marchas y contramarchas, prioritariamente mar, can el devenir social y el avance de la sociedad y se van interiorizando en el compor, tamiento personal y social de los individuos y los grupos.
La mirada diferente de los padres y madres de familia acerca del rol de la cuna en la educación inicial
Authors: Pesantes María Amalia
Published: April 2023

El objetivo de ese estudio era diseñar pautas para profesores y padres de familia orientadas a disminuir las conductas agresivas identificadas en los niños de dos a tres años que estaban en el salón de María Teresa. El estudio complementaba registros anecdóticos en clase con entrevistas en pro, fundidad a padres y madres de familia. Dichas entrevistas estaban orientadas a cono, cerno solo el sistema de premios y castigos utilizados por los padres/madres de fami, lia en el hogar, sino también a conocer un poco más el entorno familiar e identificar los puntos de apoyo entre el sistema educativo impartido en la cuna y el impartido en el hogar.
La percepción de los actores de la escuela acerca de la nueva propuesta educativa
Authors: Macavilca Maritza
Published: April 2023

El trabajo que presento a continuación es una aproximación a un centro educativo público ubicado en el distrito de San Juan de Lurigancho, donde se analiza la percepción global que el docente de la escuela tiene de este cambio de enfoque en el trabajo pedagógico, los elementos que incorpora en su tarea, los que parecen ser mal entendidos y los que considera como obstáculos en esta nueva propuesta.
PECULIARITIES OF WILLOW (Salix alba) BARK MINERAL COMPOSITION
Authors:   Federal Scientific Vegetable Center, Golubkina N. , Plotnikova U. ,   Federal Scientific Vegetable Center, Amagova Z. ,   Chechen Agricultural Institute, Sheshnitsan S. ,   Voronezh State University of Forestry and Technologies
Published: April 2023

Willow bark is highly valuable in medicine, different branches of industry and ecology. In this respect antioxidants and minerals distribution between bark tissues seems to be highly valuable. Using ICP-MS mineral composition of willow bark cambium, phloem and periderm was determined for the first time. Predominance of P, K and Ca was recorded for cambium characterized by intensive metabolism. On the contrary, periderm demonstrated the highest concentrations of all heavy metals, except Ni, Al and As, and the highest coefficients of variation compared to phloem and cambium, especially for Al (107.5%), Pb (112.2%), V (133.3%), and Sn (90.9%). Though trace elements also prevail in periderm, low coefficient of variation between tissues indicates the importance of Fe, Mn, B, Zn, Cu and Mo in plants growth. Among tissues studied cambium recorded the highest antioxidant activity with relatively similar values of polyphenol content compared to periderm and phloem data. The results prove high prospects of willow bark cambium utilization as a valuable source of antioxidants and trace elements and of periderm as a natural adsorbent. KEYWORDS: willow bark, periderm, phloem, cambium, antioxidants, minerals.
Microscopic Colitis: A Clinical Case
Authors: Reznik E. V. , Smirnova A. S. , Gudilova Y. Y. , Baykova I. E. , Golukhov G. N.
Published: April 2023

Microscopic colitis is an inflammatory bowel disease of unknown etiology that presents as chronic watery diarrhea with no endoscopic evidence of the bowel involvement but with the microscopic changes. Diagnosis of microscopic colitis is based on the histological examination of the intestinal biopsy and requires a highly qualified gastroenterologist, endoscopist and histologist. The article presents a clinical case of microscopic colitis in a 42-year-old patient, reflects the main stages of diagnosis and treatment of the patient.
CLASSIFICATION OF GUIDING BLOCKS FOR THE VISUALLY IMPAIRED USING HOG AND SVM
Authors: Mustamin Nurul Fathanah , Ma’Ruf Muhammad Afief , Taufiqurrahman Rafif
Published: April 2023

All citizens, including those with physical limitations, should be able to use public facilities and services without issue. The principles of accessibility—convenience, safety, usability, and independence—must be followed if we are to achieve social welfare in every area of life. For those with mobility or sight impairments, a guiding block (also known as a guiding tile or warning tile) can serve as an important indication. Regrettably, not all visually impaired people make use of this function in its current setup. Use a Support Vector Machine (SVM) and a His-togram of Oriented Gradient (HOG) to extract features for use in Guidance block image categorization. At a threshold of 75, the guiding blocks' classification accuracy is 99.51 percent within 30 cm, 74.811 percent within 50 cm, and 82.221 percent within 80 cm.
Socio-Economic Impact of Freelancing: Evidence From Bangladesh
Authors: Islam Md. Nazrul , Islam Md. Nahidul
Published: April 2023

In a third-world acute jobless society like Bangladesh, working-aged youth are continuously seeking for every possible source of employment through which the economic as well as social lives and realities see at least a stable going on. This analytical paper aims to examine freelancing as a device to sustain the socioeconomic actualities of the people in Bangladesh. Along with demographic data, different socioeconomic determinants-related information from 200 freelancers was collected through a structured questionnaire. The chi-square test was applied to the hypotheses to obtain the result. The findings revealed that freelancing as an employment opportunity contributes to increasing income, upgrading living standards, improving the economic stability, alleviating poverty, improving health and nutrition, continuing education, improving the social status and recognition, and having substantial future prospects. It is to publicize the concept more to raise acquaintance and take initiatives to train interested youth, especially women and provide various opportunities in prospective freelancing sources. This study will be helpful to the freelancers as they will have a clear view of the existing promising results and to future researchers also as there are numerous perspectives of the field in developing countries, notably Bangladesh.
Use of nesting resources in an Australian arid-zone landbird community
Authors: Smith Judy , Smith Peter
Published: April 2023

We investigated the use of nesting resources in a landbird community in the arid zone near Peery Lake, northwestern New South Wales. Over a 3.5-year period (1990–1994), which encompassed pre-drought, drought and post-drought conditions, we recorded 504 active nests and 51 breeding species, including open- (45% of all breeding species), hollow- (27%), mud- (8%), ground- (8%) and tunnel-nesters (4%), and species that nested both in the open and in hollows (8%). Almost 90% of observed nests were located in run-on habitats – major creeklines and minor creeklines. Forty-two species nested in, and 24 species nested only in, run-on habitats. Only 23 species nested in the much more extensive surrounding run-off habitats, but the nests of six species were located only in run-off areas. Most nests (90%) were located in plants, all of which were perennials, with 408 nests in live plants and 47 nests in dead plants. The live plants included 20 tree and shrub species ≥0.5 m tall and 4 subshrub and grass species <0.5 m tall. Most (88%) nests in perennial plants were in trees >4 m tall but often low down in the tree (only 47% of all nests in perennial plants were at heights >4 m). Different bird species favoured different plant species. Favoured trees included River Red Gum Eucalyptus camaldulensis for hollow-nesters, and Whitewood Atalaya hemiglauca and Black Box Eucalyptus largiflorens for open- and mud-nesters. Though fewer nests were located in plants <4 m tall, they were in a wider variety of plant species (16 species) than the larger number of nests in plants >4 m tall (14 plant species). Some nomadic species nested in low vegetation which, though perennial, died back and was unavailable in dry times. To support the nesting requirements of all birds, and to retain the diversity of arid-zone birds, the floristic and structural diversity of perennial plants needs to be maintained. This will be difficult to achieve if the current pattern of ongoing, incremental loss of trees and shrubs continues in the arid zone, particularly as the rate of loss is likely to be exacerbated by the impacts of climate change.
Non-monotone complexity lower bound for multivalued functions
Authors: Kochergin Vadim Vasilievich , Mikhailovich Anna Vitalievna
Published: April 2023

A lower estimate for the nonmonotone complexity of functions of a multivalued logic in an arbitrary complete finite basis, different from the upper estimates of nonmonotone complexity only for an additive constant, not basis dependent.
Synthesis of asymptotically optimal circuits with high level of functionality reveal protection in selector bases
Authors: Lozhkin Sergey Andreevich , Pavlova Anastasia Fedorovna
Published: April 2023

Research into the possibility of building for "typical" and "most difficult" FAL of any implementing their CFE in a finite complete basis, which have asymptotically optimal complexity are characterized by a high level of protection against exposing functionality by hiding some local connections. Previously proposed methods for the synthesis of SFE in the standard basis are generalized to the case of an arbitrary nonsymmetric basis.
Cellular automata and continuum
Authors: Malyshev Vadim Alexandrovich , Malyshev Sergey Vadimovich
Published: April 2023

The article turned out to completely identify one micro model of the percussion waves with a specific cellular automaton. And thus get complete solution and understanding of this model.
On structural graphs of theory of mechanisms
Authors: Kovalev Mikhail Dmitrievich
Published: April 2023

It is shown that the graph commonly used by machine scientists in the analysis structures of mechanisms does not always carry complete information about the structure. It is proposed to use more suitable graphs, in particular, a weighted graph that carries complete information.
4D printing structures for extreme temperatures using metakaolin based geopolymers
Authors: Al-Chaar Ghassan , Brandvold Allison , Kozych Andrij , Mendoza William
Published: April 2023

Geopolymers (GPs) are a class of amorphous, aluminosilicate-based ceramics that cure at room temperature. GPs are formed by mixing an aluminosilicate source, which is metakaolin in this case, with an alkali activator solution, which can be either sodium or potassium water glass. GPs have attracted interest for use in structural applications over the past few decades because they have superior mechanical properties to ordinary Portland cement (OPC). Additionally, they can tolerate much higher temperatures and produce a fraction of the CO₂ compared to OPC. This project aims to develop geopolymer composites for 4D printing (the fourth dimension being time) and test their mechanical properties. Rheology and the effects of curing in ambient conditions will be evaluated for fresh geopolymer. Freeze-thaw resistance will be evaluated on potentially printable composites for extreme temperature resistance, etc.
Youth not in Employment, Education, or Training (NEET) in Turkey: A Regional Analysis
Authors: ÖZDEMİR Mehmet Ozan , METİN OZCAN Kivilcim , ÜÇDOĞRUK Şenay
Published: April 2023

The concept of youth not in education, training, and employment (NEET) is a relatively new popular concept. Its popularity is largely due to the fact that it takes into account different vulnerabilities such as unemployment and early school leaving, which are common among young people. The aim of this study is to examine the NEET youth in Turkey. In this context, the situation of young people in NEET status is examined according to gender, age, education level, marital status, and regional differences. For this purpose, the data pooled from the Household Labor Force Survey for the years 2014-2020 was used. In the study, first, NEET interpretations were made for Turkey using descriptive statistical tools, and then a logit analysis was performed to identify the determinants of NEET in Turkey. The findings reveal that demographic characteristics such as gender, marital status, age, education level, and region of residence are among the determinants of NEET.
Stage-by-Stage Hydraulic Fracture and Reservoir Characterization through Integration of Post-Fracture Pressure Decay Analysis and the Flowback Diagnostic Fracture Injection Test Method
Authors: Zeinabady D. , Clarkson C. R.
Published: April 2023

The post-fracture pressure decay (PFPD) technique is a low-cost method allowing for stage-by-stage hydraulic fracture characterization. The analysis of the PFPD data is complex, with data affected by both hydraulic fracture and reservoir properties. Available analysis methods in the literature are oversimplified; reservoir or fracture properties are often assumed to be constant along the horizontal well, and therefore changes in the trend of pressure decay data are attributed to hydraulic fracture or reservoir properties only. Moreover, methods analogous to those applied to the analysis of conventional diagnostic fracture injection tests (DFITs) are often used and ignore critical mechanisms involved in main-stage hydraulic fracture stimulation.

A conceptual numerical simulation study was first conducted herein to understand the key mechanisms involved in main-stage hydraulic fracturing. An analytical model was then developed to account for the dynamic behavior of the hydraulic fracture, leakoff, proppant distribution, multiple fractures, and propped- and unpropped-closure events. The analytical model is cast in the form of a new straightline analysis (SLA) method that provides stage-by-stage estimates of the ratio of unpropped fracture surface area to total fracture surface area. The SLA method was validated against numerical simulation results. Moreover, to account for the variation of reservoir properties along the horizontal well, the PFPD model is integrated with DFIT-flowback (DFIT-FBA) tests, performed at some points along the lateral, to obtain a reliable stage-by-stage hydraulic fracture and reservoir characterization approach. The practical application of the proposed integrated approach was demonstrated using PFPD and DFIT-FBA data from a horizontal well completed in 22 stages in the Montney Formation.

The numerical simulation study demonstrated that the use of proppant and injection into multiple clusters (creating multiple fractures) results in multiple closure events. The closure process may start early after the pump-in period at a pressure significantly higher than the minimum in-situ stress. Using DFIT-based analytical models, which ignore the presence of proppant, causes significant errors in hydraulic fracture and reservoir property estimation. The PFPD field data examined herein exhibited a similar pressure trend to the numerical simulation cases. The ratio of unpropped fracture surface area to total fracture surface area was determined stage by stage using the PFPD SLA method, constrained by DFIT-FBA data. Engineers can use this information to optimize the hydraulic fracture stimulation design in real time, optimize the well spacing, and forecast the production. The cost and time advantages of this diagnostic method make this approach very attractive.
Apparent Heat of Reaction of Heavy Oil with Application of Accelerated Rate Calorimeter
Authors: Fazlyeva Rita , Mallory Donald , Moore Gordon , Modaresghazani Jafar , Mehta Sudarshan , Cheremisin Alexey
Published: April 2023

A series of accelerated rate calorimeter (ARC) experiments were conducted on heavy oil mixed with a carbonate core to study the thermal behavior and oxygen uptake operating at different air fluxes of 5.0, 2.5, and 1.25 (m3(ST)/(m2h)) referred to as Runs -1, -2 and -3, respectively. As a result, evaluation of the temperature rise per unit mass of oxygen was proposed as a new approach for identifying the main contributing mechanism during in-situ combustion (ISC). The obtained findings can be used for predicting the transition occurring between low- and high-temperature ranges (LTR and HTR). For Runs -2 and -3, such a transition occurred at 280°C, whereas for Run-1, operated at the highest air flux, LTR shifted to HTR at about 300°C. The overlapping curves of O2 to COx and O2 to low-temperature oxidation (LTO) plus water were interpreted as equal contributors to energy formation. The calculated maximum values varied between 4053 for LTO reactions and 13 420 dT(°C)dmO2(g) for high-temperature oxidation (HTO) reactions depending on the air flux.

The measured self-heat rates (SHRs) and oxygen uptake, further used to obtain the apparent heat of reaction, were in general agreement with the values reported in the literature, 16 000 J/g O2 consumed. These values are typical for the HTO reactions; however, in this study, the heats of reaction when the oxidation reactions are operating in the oxygen addition or LTO mode were the main interest. Depending on the run, the apparent heats of LTO reactions varied between 4422 and 7101 J/g O2 consumed.
A Global Neuronopathic Gaucher Disease Registry (GARDIAN): A Patient-Led Initiative
Authors: Collin-Histed Tanya , Stoodley Madeline , Beusterien Kathleen , Elstein Deborah , Jaffe Dena H , Revel-Vilk Shoshana , Davies Elin Haf
Published: April 2023

Background
Gaucher disease (GD) is a rare autosomal recessive lysosomal storage disorder. GD types 2 and 3 are known as neuronopathic Gaucher disease (nGD) because they have brain involvement that progresses over time. Implementing a systematic approach to the collection of real-world clinical and patient-relevant outcomes data in nGD presents an opportunity to fill critical knowledge gaps and ultimately help healthcare providers in the management of this patient population. This paper summarizes the development of a patient-initiated Gaucher Registry for Development Innovation and Analysis of Neuronopathic Disease (GARDIAN).
Methods
The International Gaucher Alliance led the GARDIAN planning, including governance, scope, stakeholder involvement, platform, and reporting. Registry element input was determined in a series of meetings with clinical experts, patients, and caregivers, who identified key clinical variables and the draft content of nGD patient-reported outcomes (PRO) and observer-reported outcomes (ObsRO) focusing on symptoms, patient physical and emotional functioning. These were then tested in cognitive interviews with patients with nGD (> 12 years of age) and caregivers.
Results
Core registry data elements (n = 138) were identified by seven global clinical experts from Egypt, Germany, Israel, Japan, United Kingdom (UK), and United State (US) and reviewed via online Delphi method by 14 additional clinicians with experience of nGD from six countries and three pharmaceutical representatives. The elements were consistent with those identified via interviews with 10 patients/caregivers with nGD from Japan, Sweden, UK, and US. Key domains identified were demographics, diagnostic information, health status, clinical symptomatology, laboratory testing, treatment, healthcare resource utilization, aids/home improvements, and patient/caregiver burden and quality of life, specifically physical functioning, self-care, daily and social activities, emotional impacts, support services, and caregiver-specific impacts. Nine caregivers and six patients from the US, UK, China, Mexico, Egypt, and Japan participated in the cognitive interviews that informed revisions to ensure that all items are understandable and interpreted as intended.
Conclusions
The comprehensive set of clinical and patient relevant outcomes data, developed collaboratively among all stakeholders, to be reported using GARDIAN will bridge the many gaps in the understanding of nGD and align with regulatory frameworks on real-world data needs.
The Relationship among self-care, disease knowledge and hope in patients with heart failure
Authors: Mehri Zahra , Kheiry Fatemeh , Rakhshan Mahnaz
Published: April 2023

Background: Self-care, disease knowledge, and hope have been considered critical concepts in health-related research. So that all three of them are considered solutions to control heart failure and reduce its complications. The present study was conducted to determine the correlation of self-care with disease knowledge and hope in heart failure patients referred to Imam Reza Clinic, Shiraz, Iran.
Methods: In this correlational and cross-sectional descriptive study, the data of 85 heart failure patients referred to Imam Reza Clinic, Shiraz, Iran in 2021 were examined. Heart failure patients' self-care instruments based on Orem's self-care theory, the Heart Failure Knowledge Scale-Persian version, and the Heart Hope Index-Persian version were used in the present study. To analyze the data, descriptive statistics and the Pearson correlation coefficient were used.
Results: Out of 85 heart failure patients, 56.50% of the samples were male, and 43.50% were female. The mean and standard deviation of the self-care score was 196.54±25.54, the heart failure knowledge score was 4.49±2.59, and the score of hope was reported as 32.41±4.52 in these patients. The analysis of the Pearson correlation coefficient indicates the presence of a positive and significant correlation between "self-care and hope" (r=0.506, p<0.0001), "heart failure knowledge and hope" (r=0.409, p<0.0001), and self-care and heart failure knowledge" (r=0.407, p<0.0001).
Conclusions: Considering the positive and significant correlation between "self-care and heart failure knowledge", "self-care and hope", and "heart failure knowledge and hope", it seems to be necessary for doctors and nurses to pay attention to providing educational programs regarding increasing the heart failure knowledge to improve self-care and hope in heart failure patients.
Seismic evidence for deep hydrothermal circulation and faulting at slow spreading Mid-Atlantic Ridge
Authors: Vaddineni Venkata , Jian Hanchao , Singh Satish
Published: April 2023

Oceanic crust at slow spreading ridges is formed by a combination of magmatic and tectonic processes, where the heat is mined through hydrothermal circulation, but how deep and for how long the hydrothermal circulation occurs remain unknown. Using a combined P-wave and S-wave tomography of ocean bottom seismometer data at the equatorial Mid-Atlantic Ridge, here we show the presence of a high P- to S-wave velocity ratio beneath the ridge axis extending down to 5 km below the seafloor in a 50-km wide zone, indicating the occurrence of deep hydrothermal circulation extending up to ~1.6 Ma. Furthermore, full waveform inversion of coincident multi-channel seismic data shows extensive faulting penetrating down to 4 km depth, allowing the water to circulate deep into the crust, enabling a robust hydrothermal circulation. The presence of a 30-km wide low P-wave velocity anomaly in the mantle underneath reveals the existence of a thermal anomaly providing the heat source, invigorating the deep hydrothermal circulation. These results suggest that most of the heat is mined in the first 1.6 Ma, prior to the initiation of slow conductive plate cooling, the subsequent seafloor subsidence, and the lithospheric evolution.
Error per single-qubit gate below $10^{-4}$ in a superconducting qubit
Authors: Liu Weiyang , Li Zhiyuan , Liu Pei , Zhao Peng , Mi Zhenyu , Xu Hui-Kai , Liang Xuehui , Su Tang , Sun Weijie , Xue Guangming , Zhang Jing-Ning , Jin Yi-Rong , Yu Haifeng
Published: April 2023

Implementing arbitrary single-qubit gates with near perfect fidelity is among the most fundamental requirements in gate-based quantum information processing. In this work, we fabric a transmon qubit with long coherence times and demonstrate single-qubit gates with the average gate error below 10-4, i.e. (7.42±0.04)×10-5 by randomized benchmarking (RB). To understand the error sources, we experimentally obtain an error budget, consisting of the decoherence errors lower bounded by (4.62±0.04)×10-5 and the leakage rate per gate of (1.16±0.04)×10-5. Moreover, we reconstruct the process matrices for the single-qubit gates by the gate set tomography (GST), with which we simulate RB sequences and obtain single-qubit fedlities consistent with experimental results. We also observe non-Markovian behavior in the experiment of long-sequence GST, which may provide guidance for further calibration. The demonstration extends the upper limit that the average fidelity of single-qubit gates can reach in a transmon-qubit system, and thus can be an essential step towards practical and reliable quantum computation in the near future.
High Uric Acid Orchestrates Ferroptosis to Promote Doxorubicin-Induced Cardiomyopathy via ROS-GPX4 Signaling
Authors: Cheng Jidong , Xu Chenxi , Yu Wei , Xie De , Wang Qiang , Chen Binyang , Yang Haiyan , Xi Yuemei , Yu Linqian , Yan Yunbo , Yamamoto Tetsuya , Koyama Hidenori
Published: April 2023

Background: Doxorubicin (DOX) is a chemotherapeutic drug that induces cardiotoxicity known as doxorubicin -induced cardiomyopathy(DIC). Studies have confirmed that DOX can cause cardiac damage via ferroptosis. High uric acid (HUA), as a pro-oxidant, participates in the pathophysiology of cardiovascular disease. Epidemiological studies suggest elevated uric acid levels can have detrimentaleffects on cardiovascular disease. However, the effect of hyperuricemia in a specific type of cardiomyopathy, DIC, is unclear. It is unknown if HUA exacerbates DIC and if the tumor patients with hyperuricemia will aggravate the cardiac side effects of DOX.
Methods: In uricase knockout (Uox-/-) mice, we explored the effect of HUA on DOX-induced cardiotoxicity, including cardiac function, pathomorphology, and its mechanism.
Results: We demonstrated that Uox-KO mice accelerated the development of DIC, causing significantly impaired cardiac function and myocardial fibrosis. Meanwhile, the mitochondrial morphology was destroyed, the lipid peroxidation products increased in number and the antioxidant function was weakened. In addition, we evaluated the effects of ferrostatin-1 (Fer-1), the ferroptosis inhibitor. Myocardial damage can be reversed by the Fer-1 treatment caused by HUA combined with DOX treatment. Benzbromarone, a UA-lowering drug, decreases myocardial fibrosis and ferroptosis by alleviating hyperuricemia in Uox-KO mice by DOX administration. In vitro, we observed that the activity of cardiomyocytes treated with HUA combined with DOX decreased significantly, and lipid reactive oxygen species (ROS) increased significantly. Afterwards, we demonstrated that HUA can promote oxidative stress in DOX, characterised by increased mitochondrial ROS, and down-regulate protein levels of glutathione peroxidase 4 (GPX4). N-acetyl-L-cysteine, an antioxidant, inhibits the process by which HUA promotes DOX-induced ferroptosis by increasing the GPX4 expression.
Conclusions: Our data suggested that HUA promotes the DIC. And HUA promotes DOX-induced ferroptosis by increasing oxidative stress and down-regulating GPX4. It is implied that tumor patients with hyperuricemia may increase cardiac side effects when taking DOX during chemotherapy treatment.
Metabolomics in vitreous fluid of retinal detachment associated with choroidal detachment patients
Authors: Yang Lufei , Luo Shasha , Chen Yanghao , Gong Xuechun , Wu Zhifeng
Published: April 2023

Background
Rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) is a complex type of retinal detachment. This disease is characterized by high difficulty of operation and poor prognosis. However, the pathogenesis is still unclear. The purpose of this study was to analyze the changes of metabolites and metabolic pathways in vitreous fluid of RRDCD patients.
Method
Using ultra-high-performance liquid chromatography coupled with the quadrupole time-of-flight mass spectrometry method, metabolites in the vitreous fluid of RRDCD and idiopathic epimacular membrane (IEMM) patients were analyzed. A total of 28 samples were analyzed to compare the significance of different metabolites between these groups.
Results
We identified 135 different metabolites between the RRDCD and IEMM groups (VIP > 1, P value < 0.05). Compared with the IEMM group, the level of sphingomyelin, adenosine, L-palmitoylcarnitine and 4,7,10,13,1 6,19-docosahexaenoic acid up-regulated in RRDCD group. A series of lipid metabolites were up-regulated in RRDCD group. The main metabolic pathways involved were protein digestion and absorption, ABC transporters, aminoacyl-tRNA biosynthesis, central carbon metabolism in cancer and sphingolipids metabolism.
Conclusions
Our results suggest that the up-regulation of sphingomyelin and abnormal sphingolipids metabolism may induce cell migration and death after retinal or choroidal detachment. And then, it may induce intraocular inflammation and damage visual function. The accumulated L-palmitoylcarnitine and fatty acid metabolites may damage the energy pathway of retina, and aggravate the death of photoreceptors after hypoxia. These results provide clues for studying the mechanism, treatment and prognosis of RRDCD.
Influencing Factors of the Treatment Level of Elderly Care Workers and Their Career Development Prospects
Authors: cui kaichang , Yang fei , Qian Ruihan , Li Chenmei , Fan Mengting
Published: April 2023

Background: The increasingly aging population in current China has encouraged the emergence of the diversified and multi-level elderly care service industry, and the demand for high-quality elderly life with the help of elderly caregivers continues to grow.
Methods: Based on the existing questionnaire data, this article explores the influencing factors of the treatment level of care staff, and explores their future development prospects.
Results: The results show that whether they have participated in relevant vocational skills competitions, whether they have worked overtime, whether they have overtime wages, and their monthly income have significant effects on their satisfaction of treatment levels. Elderly care workers who have participated in skills competitions are more satisfied about their salary. In addition, workers who rarely and occasionally work overtime are more satisfied compared with those who have never worked overtime; Caregivers with a monthly income of 5,000-6,999 yuan are more satisfied with their salary and treatment than those with below 3,000 yuan.
Conclusion: Therefore, in order to better match the supply and demand of care workers, we should provide formal training and skill competitions for them, appropriately increase their salary level and reasonably arrange their working hours, so as to attract more professional talents into elderly care industry.
Scalable Interconnection Using a Superconducting Flux Qubit
Authors: Saida Daisuke , Hidaka Mutsuo , Makise Kazumasa
Published: April 2023

To improve the performance of quantum computers, implementation technology that guarantees the scalability of the number of qubits is essential, and increasing the degrees of freedom in routing by 2.5-dimensional implementation is important for realizing the scalability of circuits. Here, we achieve long-distance coupling using a superconducting flux qubit enabling routing on the order of millimeters. We report the design for a reliable connection qubit with a proof-of-concept demonstration of quantum annealing. We perform experiments and simulations on suppressing errors due to coupling. The coupling status is strictly controllable, enabling elimination of crosstalk from the unintentional circuit region. A low-temperature flip-chip bonding technology is introduced for the 2.5-dimensional interconnection. The superconducting flux qubit, formed across two different chips via bumps, is demonstrated for the first time to show a state transition similar to that in a conventional qubit. The connection qubit and flip-chip bonding pave the way for new interconnections between different types of qubits. The possibility of interactions between gate-type qubits is investigated in a simulation.
Proportion of HIV exposed infants aged 0-6 months that missed nevirapine prophylaxis in Mulago National Referral Hospital, Uganda: a cross-sectional study
Authors: Hellen Nasambu , Joseph Rujumba , Ezekiel Mupere , Fred Semitala , Philippa Musoke , Senyonga Ronald
Published: April 2023

Background:Nevirapine prophylaxis has been found to lower the risk of HIV transmission in breast-fed infants. While about 95% of pregnant and lactating mothers use Antiretroviral therapy in Uganda, a smaller percentage of HIV exposed infants (HEI)receive nevirapine (NVP)prophylaxis. This study aimed to determine the proportion of HEI whomissed NVP prophylaxis and associated factors.Methods:This was a cross-sectional study done using quantitative methods. It was conducted at Mulago National Referral Hospital. A total of 228mother-infant pairs were enrolled.The proportion of HEI who missed NVP, maternal, infant and health facility factors associated were measured using a pre-tested questionnaire. Bivariate analysis and binary logistic regression model were used to determine the proportion and factors associated with missing NVP prophylaxis.Results:The proportion of HEI who missed NVP prophylaxis was 50/228(21.9%). Factors significantly associated with HEI missing NVP prophylaxis included; delivery from outside government health facilities [AOR=8.41 95% (CI 3.22-21.99)], mothers; not undergoing PMTCT counselling [AOR=12.01 95% (CI 4.53-31.87)],not on ART[AOR=8.47 95% (CI 2.06-34.88)] and not having disclosed their HIV status to their partners [AOR=2.80 95% (CI 1.13-6.95)].The HEI that missed nevirapine and were HIV positive were 35 (70.0%).Conclusion: One in five HEI missed NVP prophylaxis and nearly three quarters of those who missed NVP prophylaxis were HIV infected. Improving uptake of nevirapine by HEI will require interventions tostrengthen PMTCT counselling, assisted partner notification, reduction of HIV stigma and support to the private sector in the provision of PMTCT services.
Role of soil nutrient elements transport on Camellia oleifera yield under different soil types
Authors: Chen Yu , Zheng Jinjia , Yang Zhijian , Xu Chenhao , Liao Penghui , Pu Shaosheng , El-Kassaby Yousry A. , Feng Jinling
Published: April 2023

Background
Most of C. oleifera forests have low yield and poor quality, largely associating with soil fertility. Soil physical and chemical properties interact with each other to affect soil fertility. C. oleifera growing under different soil conditions affected their yield and oil composition. Three main soil types were selected, and redundancy, correlation, and double-screening stepwise regression analysis were used, for exploring the relationships between Camellia oleifera nutrients uptake and soil physical and chemical properties, shedding light on the transport law of nutrient elements from root, leaves, and kernel, and elaborating the regulation of fruit yield and oil composition.
Results
In the present study, available soil elements content of C. oleifera forest were mainly regulated by water content, pH value total N, P and Fe contents. Seven elements (N, P, K, Mg, Cu, Mn and C) were key for kernel’s growth and development, with N, P, K, Cu and Mn contents determining the yield traits. The transport characteristics of these nutrients from root, leaves to the kernel were synergistic and antagonistic effects. There were two ways to control the oil production and the content of various oil components: one was to adjust N, P, K, Mg, Zn, Fe and Cu contents of leaves by applying corresponding foliar fertilizers, while the other was to change the soil water content and pH, and apply N, P, Zn, Mg and Ca fertilizers.
Conclusion
Soil type controlled nutrient absorption by soil pH, water content and total N, P and Fe content. There were synergistic and antagonistic effects on the inter-organ transport of nutrient elements, ultimately affecting the contents of N, P, K, Cu and Mn in kernel, which determined the yield and oil composition of C. oleifera.
Copper-Sulfur-Nitrogen Cluster Providing a Local Proton for Efficient Carbon Dioxide Photoreduction
Authors: Dong Jian-Peng , Xu Yue , Zhang Xun-Guang , Zhang Huan , Yao Ling , Wang Rui , Zang Shuang-Quan
Published: April 2023

Atomically precise Cu clusters are highly desirable as catalysts for CO2 reduction reaction (CO2RR), and they provide an appropriate model platform for elaborating their structure–activity relationship. However, an efficient overall photocatalytic CO2RR with H2O using assembled Cu-cluster aggregates as heterogeneous photosensitive semiconductors has not been reported. Herein, we report a stable crystalline Cu–S–N cluster photocatalyst with local protonated N–H groups (denoted as Cu6–NH). The catalyst exhibits suitable photocatalytic redox potentials, high structural stability, active catalytic species, and a narrow bandgap, which account for its outstanding photocatalytic CO2RR performance under visible light, with ~100% selectivity for CO evolution. Remarkably, systematic isostructural Cu-cluster control experiments, in situ infrared spectroscopy, and density functional theory calculations revealed that the protonated pyrimidine N atoms in the Cu6–NH cluster act as a proton relay station, providing a local proton during the photocatalytic CO2RR. This efficiently lowers the energy barrier for the formation of the *COOH intermediate, which is the rate-limiting step, efficiently enhancing the photocatalytic performance. This work lays the foundation for the development of atomically precise metal-cluster-based photocatalysts.
Construction of a prognostic model for gastric cancer patients based on NAD+ metabolism-related genes and tumor microenvironment analysis
Authors: Xing Yu , Zhang Zili , Gao Wenqing , Song Weiliang , Li Tong
Published: April 2023

Background
Nicotinamide adenine dinucleotide (NAD+) metabolism is important in the regulation of tumor immune escape. This study endeavored to develop a NAD + metabolism-related signature in gastric cancer (GC), which could provide a theoretical foundation for prognosis and therapy of GC patients.
Methods
First, differentially expressed genes (DEGs) between GC and paraneoplastic tissues were intersected with NAD + metabolism-related genes (NMRGs) to obtain differentially expressed NMRGs (DE NMRGs). Then, based on the transcript levels of NMRGs, GC patients were classified into high and low scoring groups using the Gene set variation analysis (GSVA) algorithm. Next, the DEGs between the high and low scoring groups were intersected with DEGs between GC and paraneoplastic tissues to obtain the GC-NM DEGs. Additionally, univariate Cox analysis and Least absolute shrinkage and selection operator (LASSO) regression analysis of GC-NM DEGs were performed to obtain prognostic biomarkers, which were used to construct a risk model. In addition, independent prognostic factors were obtained by Cox analysis based on risk scores and clinicopathological factors. Gene set enrichment analysis (GSEA) enrichment analysis and immune infiltration analysis were performed for the high- and low-risk groups. Finally, the mRNA expression of prognostic related genes was verified by experiment.
Results
10 DE NMRGs were obtained and they were involved in the biological process of NAD biosynthetic process, nicotinamide nucleotide, and biosynthetic process. Further 7 biomarkers, including DNAJB13, CST2, THPO, CIDEA, ONECUT1, UPK1B, and SNCG, were obtained through univariate Cox and LASSO analyses of 1001 GC-NM DEGs. In addition, risk score and gender were demonstrated as credible independent prognostic factors for GC. Moreover, GSEA showed that the high-risk group was associated with bile secretion, intrinsic component of synaptic membrane and other pathways, while the low-risk group was associated with CMG complex. In addition, T cells, B cells, and natural killer cells were positively correlated with risk scores, and plasmacytoid dendritic cells were negatively correlated with risk scores. By QRT-PCR, the expression of prognostic genes in GC tissues was significantly up-regulated compared with paraneoplastic tissues.
Conclusion
This study established a NAD + metabolism-related signature based on DNAJB13, CST2, THPO, CIDEA, ONECUT1, UPK1B, and SNCG, which is of great significance in developing prognostic molecular biomarkers, clinical prognosis prediction, and treatment strategy decision for GC patients.
A two-dimensional risk assessment method for oil and gas pipelines based on "accident probability - reputation loss"
Authors: chen xuefeng , chen wentao , Zhang YIfu , Peng Bin , Wang yuling , Xu mingwei
Published: April 2023

Oil and gas pipeline accidents not only caused personnel casualties, economic losses and environmental pollution, but also brought great panic to the public. In order to provide accurate accident prevention strategies, risk assessment (RA) has been widely used in the oil and gas pipeline industry. It aims to quantify the potential risk due to unexpected eventualities. However, the current RA methods mainly pay attention to the tangible risk (such as the human safety risk, economic risk and environmental risk), the intangible risk ( such as reputation loss risk) is often neglected. This cannot reflect the real risk for the oil and gas pipeline. To settle existing research limitation, a two-dimensional risk assessment method for oil and gas pipelines based on “accident probability - reputation loss” is proposed. The method mainly involves four steps, namely, risk identification, probability calculation, consequence assessment and risk assessment. The proposed method is used to quantitatively assess a natural gas pipeline in central China. Its results indicate that the pipeline risk is unacceptable. Therefore, this study can enrich and develop the current oil and gas pipeline RA method to reflect the real risk of oil and gas pipeline accidents.
A method of Gas sensor drift compensation based on intrinsic characteristics of response curve
Authors: Sun Yubing , Zheng Yutong
Published: April 2023

Sensor drift is an inevitable and challenging problem in gas sensing and an important problem in signal processing, as it seriously affects the detection performance and service life of sensor. In this study, a new sensor drift compensation method, which is based on intrinsic characteristic of sensory response, is proposed. The dataset for two different volatile organic compounds with a period of 36 months are employed and two kinds of features (one is steady-state feature, another is transient feature) are extracted. Their relationship is built and its change rule with sensor drift is explored. Then, drift compensation method is processed based on the change rule through iteration making the drifted sensor features adjusted to the value of month 1, which is considered as having no drift phenomenon. Moreover, the process is rapid. Finally, SVM is employed for proving the performance of the sensor drift compensation method proposed in this study. The results show the efficacy of 22 month of continuous monitoring, which has been enough for most application scenario, and almost 20% of increasement of correct classification rate of SVM after drift compensation, which indicates the effect of drift compensation method.