bluuebunny/crossref_metadata_2025 huggingface dataset:
Организация онкологической службы Республики Башкортостан
Authors: Забелин М. В. , Измайлов А. А. , Аюпов Р. Т. , Закирова Л. К. , Волынцева Э. Р. , Рахимов Р. Р. , Султанбаев А. В.
Published: November 2021

Аннотация: Злокачественные новообразования остаются одной из важнейших проблем в области медицины и здоровья населения и одной из наиболее значимых статей расходов системы здравоохранения в целом по России, так и по Республике Башкортостан в частности [1]. В статье представлена динамика основных показателей онкологической службы, анализ оказания онкологической помощи населению. Онкологическая служба республики имеет многоуровневую систему, представлена онкодиспансером, межрайонными онкологическими отделениями, межмуниципальными медицинскими онкоцентрами, центрами амбулаторной онкологической помощи и первичными онкологическими кабинетами, также открыты филиалы онкодиспансера — онкологические отделения противоопухолевой лекарственной терапии на базе многопрофильных медицинских организаций республики. В рамках регионального проекта «Борьба с онкологическими заболеваниями» переоснащены медицинским оборудованием 10 медицинских организаций республики, в них поставлено 289 ед. оборудования за счет средств федерального бюджета и бюджета Республики Башкортостан: ОФЭКТ/КТ/МРТ, маммографы, линейные ускорители комплекса лучевой, эндоскопические видеокомплексы, аппарата для патоморфологии и др.Цель исследования: Анализ организации онкологической помощи населению Республики Башкортостан, целевых показателей регионального проекта «Борьба с онкологическими заболеваниями».Материалы и методы: Для анализа состояния онкологической службы Республики Башкортостан изучались данные Федерального ракового регистра ФГБУ «Московский научно-исследовательский онкологический институт им. П.А. Герцена» Минздрава России, регионального ракового регистра, территориального фонда обязательного медицинского страхования [2,5].Результаты: Заболеваемость злокачественными новообразованиями в 2020 году составила 273,4 на 100 тыс. человек, что на 20,4% ниже 2019 года. Выявляемость злокачественных новообразований на ранних 1–2 стадиях составила 51,9% от числа впервые зарегистрированных злокачественных новообразований. Несмотря на значительный рост, показатель ранней диагностики остается ниже российского значения на 8,5%. В период пандемии отмечается снижение смертности от злокачественных новообразований до 169,6 на 100 тыс. населения, что ниже 2019 года на 5,7%.Заключение: Несмотря на положительную динамику реализации регионального проекта ««Борьба с онкологическими заболеваниями», остается определенный риск невыполнения поставленных задач. Важная задача — сохранение уровня помощи онкологическим пациентам, в том числе с коронавирусной инфекцией.
Практические рекомендации по лекарственному лечению нейроэндокринных неоплазий лёгких и тимуса
Authors: Орел Н. Ф. , Артамонова Е. В. , Горбунова В. А. , Делекторская В. В. , Емельянова Г. С. , Кузьминов А. Е. , Любимова Н. В. , Маркович А. А. , Орлов С. В.
Published: November 2021

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Практические рекомендации по лекарственному лечению метастатических опухолей головного мозга
Authors: Насхлеташвили Д. Р. , Банов С. М. , Бекяшев А. Х. , Борисова Т. Н. , Ветлова Е. Р. , Голанов А. В. , Зайцев А. М. , Кобяков Г. Л. , Смолин А. В.
Published: November 2021

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Практические рекомендации по лекарственному лечению рака коры надпочечника
Authors: Горбунова В. А. , Коломейцева А. А. , Бельцевич Д. Г. , Бохян В. Ю. , Мельниченко Г. А. , Переводчикова Н. И. , Феденко А. А.
Published: November 2021

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Практические рекомендации по лекарственному лечению нейроэндокринных неоплазий желудочно-кишечного тракта, поджелудочной железы и других локализаций
Authors: Орел Н. Ф. , Артамонова Е. В. , Горбунова В. А. , Делекторская В. В. , Емельянова Г. С. , Любимова Н. В. , Маркович А. А. , Орлова К. В. , Орлова Р. В. , Трифанов В. С.
Published: November 2021

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género y las subjetividades políticas
Authors: Flórez Natalia
Published: November 2021

Este artículo expone los resultados de la investigación de Maestría en Estudios Latinoamericanos de la Pontificia Universidad Javeriana, cuya sistematización de experiencias se centró en comprender la configuración de las subjetividades políticas del colectivo de Mujeres EntreRedes en medio de su proceso de educación popular. Así pues, para llevarlo a cabo se utilizó el método biográfico y autobiográfico narrativo que logró consolidar los objetivos, las prácticas organizativas, los momentos significativos, las actividades, los aprendizajes y los retos que enfrentan las mujeres diversas en el actual contexto capitalista, neoliberal y patriarcal propio del sistema hegemónico globalizador; en consecuencia, se dio cuenta de cómo los sectores populares han impulsado propuestas de educación popular feministas que buscan, a partir de prácticas políticas, transformar los espacios y las estructuras socialmente establecidas. Además, los relatos permitieron comprender que la formación política —como un eje transversal— es un campo productor de conocimiento que permite la materialización de transformaciones sociales e identitarias, en donde cobra especial relevancia la memoria como posibilidad de reconstrucción de la historia individual y colectiva, contribuyendo así a enriquecer el campo epistemológico.
Programa Binacional de Educación Migrante en el estado de Baja California, 2014-2019: análisis de resultados
Authors: Osuna García José Candelario
Published: November 2021

El presente artículo contiene un resumen de resultados del Programa Binacional de Educación Migrante durante la administración de Francisco Vega de Lamadrid, gobernador constitucional del estado de Baja California para el periodo 2014-2019, haciendo énfasis en los avances y limitaciones del plan de trabajo sexenal. Para ello, se llevó a cabo un análisis de documentos oficiales con el propósito de establecer la congruencia entre las metas, estrategias y líneas de acción de las declaraciones internacionales con el plan nacional y estatal de desarrollo, así como con el plan de trabajo de dicho programa federal en esta entidad federativa. Adicionalmente, se realizó una búsqueda y análisis de notas periodísticas en medios locales de comunicación escrita y digital para conocer los informes emitidos y los acontecimientos celebrados por la coordinación estatal de educación migrante, en el mismo periodo de tiempo, como una aproximación a la evaluación del desempeño.
Espacios de la política. Cartografías, geoculturas y geopolíticas americanas
Authors: Saballes Martin
Published: November 2021

Oscar Madoery es politólogo y doctor en ciencias sociales, con una rica experiencia en desarrollo territorial; dirige el doctorado en Ciencia Política de la Universidad Nacional de Rosario, Director de la Escuela de Ciencia Política y es profesor e investigador titular de esa universidad. Sus múltiples obras conjugan una sólida formación teórica con una amplia perspectiva latinoamericana; su pensamiento y su práctica se encuentran fuertemente arraigadas en las realidades sociohistóricas, políticas y culturales de nuestras sociedades, en diálogo crítico e incisivo con otros enmarcamientos teóricos y otros procesos.Espacios de la memoria presenta la relación entre espacio, política y cultura en un ejercicio de pensamiento situado como crítica a lo “global homogéneo” como toma de posición epistemológica. Lo universal, sostiene Madoery a través de toda la obra, es lo universal europeo, producto de la expansión colonial-imperialista del capitalismo europeo a partir del siglo XVI. El libro que puede ser leído como una continuación de su anterior Los desarrollos latinoamericanos y sus controversias (publicado en 2016 por la Universidad Nacional de Tierra del Fuego); continuidad reconocida por el propio autor. Es, sin embargo, una continuidad en un nivel conceptual y argumentativo diferente. El territorio aparece ahora no sólo como producto político de la delimitación de un espacio geográfico-económico, o la materia sobre la que las relaciones de poder operan y de la que se apropian; es sobre todo ámbito de generación cultural donde un grupo de población define su identidad, desenvuelve su existencia cotidiana y se relaciona con otras poblaciones, espacios y culturas. El autor desarrolla su argumento en tres capítulos (Cartografías, Geoculturas, Geopolíticas) precedidos por dos prólogos (Vilas y Madoery), una introducción y un “Mensaje de cierre: Lo político desde el suelo”.
De la servidumbre por deudas al trabajo indecente. Grupos económicos, mundo del trabajo y derechos humanos en Latinoamérica
Authors: Trotta Miguel
Published: November 2021

El libro de Daniel Cieza abarca y profundiza en todos los tópicos señalados, a lo largo de un texto compuesto por diecisiete capítulos, desde la perspectiva de la investigación acción. Proponiendo miradas de los distintos universos de la producción de diversos bienes en la contradictoria y compleja realidad laboral de nuestra América Latina. Si bien enfatiza en el caso de la región, su análisis incorpora las tendencias generales estructurales y coyunturales del mundo del trabajo desde el siglo XX hasta la primera década del siglo XXI.El autor está particularmente calificado para tratar el tema. Abogado con temprano e intenso ejercicio de su profesión en materia laboral y de derechos humanos, sociólogo y doctor en ciencias sociales, involucrado en las luchas por la democracia y la emancipación social, cuenta por experiencia personal y reflexión crítica con una visión amplia de las cuestiones que su libro analiza.Plantea desde un abordaje multidisciplinario, que en la actualidad los derechos consagrados por las normas nacionales e internacionales son vulnerados sistemáticamente por las grandes corporaciones económicas y por las instituciones estatales que deben velar por su control. Presenta en ese marco, un análisis diacrónico de la contradicción entre vulneración de derechos y control estatal que abarca todo el siglo XX hasta el siglo XXI. Afirma que la servidumbre por deudas (análoga a la esclavitud) hacia comienzos del siglo XX fue superada promediando el mismo, por la consagración de los derechos sociales.
Funkcja turystyczno-wypoczynkowa Mrągowa
Authors: Olszewska Barbara
Published: November 2021

W pracy podjęto próbę kompleksowego określenia funkcji turystyczno-wypoczynkowej Mrągowa. Materiały potrzebne do opracowania tego tematu zdobyto podczas badań terenowych prowadzonych w 1984 r. Celem tych badań było znalezienie odpowiedzi na następujące pytania:

1. Czy Mrągowo pełni funkcję turystyczno-wypoczynkową; jeśli tak, to co zadecydowało o jej rozwoju i jaka jest obecnie rola tej funkcji w przestrzeni i życiu miasta?

2. Jaki zasięg przestrzennego oddziaływania posiada funkcja turystyczno- wypoczynkowa Mrągowa?

3. W jakim stadium rozwoju znajduje się badana funkcja w Mrągowie?

W niniejszej pracy funkcję turystyczno-wypoczynkową utożsamia się z działalnością gospodarczą, której istotą jest świadczenie dóbr i usług na rzecz turystów i własnych mieszkańców przy wykorzystaniu atrakcyjności turystycznej danej jednostki przestrzennej.
Flood Disaster Risk, Sense of Place, and Preparedness of Entrepreneurs in Communities along a River
Authors:   Siliman University, Oracion Enrique
Published: November 2021

This paper investigated the flood experiences of entrepreneurs in communities along the Ocoy River in Negros Oriental. It further examined the relationships among flood disaster risk perception, sense of place, and flood disaster preparedness of the respondents composed of 36 non-probable samples of owners and managers of enterprises near the river. The face-to-face survey revealed that most had accumulated damage and losses during floods, reinforcing their high flood disaster risk perceptions. But the latter was positively and significantly related to their sense of place score, which suggests a high value they assigned to their communities despite a high flood risk. However, they had a low disaster preparedness score which is not significantly related to flood disaster risk perception and a sense of place. Only place dependence had a positive and significant relationship to flood disaster preparedness which explains their reluctance to relocate their operations. Therefore, as part of enterprises’ formal operational requirements for a business permit, the entrepreneurs must undergo flood disaster preparedness orientation to adapt to climate change.
Dimensiones estratégicas para evaluar la efectividad de la Evaluación del Impacto Ambiental, bajo la legislación ambiental peruana
Authors: Espinoza Ortiz Diego Mauricio , Jiménez Peña Gaspar , Páez Warton José , Evangelista Vargas Diego , Salas Delgado Milward , Ramos Guillén Marta , Carrera Saavedra Henry , Natividad María Ángeles
Published: November 2021

A treinta años de su implantación en la legislación nacional del Perú, la Evaluación del Impacto Ambiental (EIA) ha sido revisada con la finalidad de determinar qué indicadores podrían emplearse para evaluar su efectividad. Fueron analizadas fuentes de información sobre la calidad y efectividad de la EIA para el uso sostenible de recursos naturales, logrando un modelo conceptual de cadena de valor para la gestión por resultados desde la administración pública, identificando los insumos y las actividades para ofrecer un servicio de certificación ambiental que resulte específicamente en el uso sostenible de recursos naturales, y contribuya al goce de un ambiente equilibrado y adecuado al desarrollo de la vida. De la revisión efectuada a los trabajos de Chanchitpricha y Bond (2013), Bond et al. (2015) y Pope et al. (2018), entre otros, se distinguen seis dimensiones que permiten evaluar la efectividad de la EIA, referido al uso sostenible de los recursos naturales, que son: i) normativa, alcanzando las metas establecidas en las políticas; ii) participativa, involucrando de forma segura y confiable a las partes interesadas; iii) organizacional, facilitando la gestión del conocimiento sobre la EIA como herramienta de la gestión ambiental; iv) transaccional, gestionando de forma eficiente los recursos en la ejecución de la EIA, como tiempo, financieros, alcance o requisitos y habilidades del personal; v) procedimental, debido a un marco procedimental coherente y fiable; y vi) sustantiva, debido a la eficacia de la decisión tomada por la autoridad competente respecto de la viabilidad ambiental del proyecto sometido a la EIA. El trabajo es una contribución a mayores estudios sobre la efectividad de la EIA en el abordaje de los problemas ambientales y sociales que actualmente enfrentamos, y las posibles tendencias a presentarse en las futuras décadas.
Numerical simulation for increasing the sand mastic adaptation of repairing the breakwater
Authors: Jung Hyo Jun , Bang Young Jun , Lee Seung Oh
Published: November 2021

As a breakwater gradually becomes obsolete, it becomes vulnerable to loss of its original functions and finally occurs corruption due to cavitation, scours inside, etc. The mortar grouting method, which has been in general applied in many cases, would invoke serious issues such as coastal environmental pollutions because of spilled-out cement before curing on the near sea. Thus, the sand mastic that utilizes the mastic asphalt becomes focused on as a substitute. However, the related study is hard to find in the domestic literature. In this study, therefore, the workability of sand mastic when filling up the cavitation inside a breakwater was evaluated with a 3-D numerical model, FLOW-3D. It was intended to propose the workability index (WI) of sand mastic based on the diffusion diameter. It has been shown that the temperature and the composition ratio of the asphalt are the most significant parameters on the rheologic characteristics of the sand mastic. As a result, it is recommended that the asphalt composition above 16% and the initial temperature above 150℃ when applying with a breakwater with inside cavitation.
AKTIVITAS ANTIBAKTERI FRAKSI SAPONIN DARI KULIT BATANG TUMBUHAN KASTURI (Mangifera casturi)
Authors: Rosyidah K. , Nurmuhaimina S. A. , Komari N. , Astuti M. D.
Published: November 2021

This research to study antibacterial activity (E.coli and S.aureus) of saponin fractions from stem bark of Mangifera casturi. Powdered of stem bark of M.casturi (512,67 g) were extracted with methanol. Methanol extract (32.57 g) was partitionated with n-hexane to give saponin extract. Saponin extract (5.98 g) was partitionated by Vacuum Liquid Chromatography (VLC) over silica gel to give 39 fractions were grouped into four major fractions A-D by combining fractions with similar TLC profile. Every fractions studied antibacterial activity with E. coli and S. Aureus with difusi methode. Fraction A most active then other fraction with inhibition diameter 10.3 ± 0.5 mm (E.coli) and 10.8 ± 0.3 mm (S.aureus).
PENAPISAN BAKTERI YANG BERASOSIASI DENGAN SPONS JASPIS SP. PENGHASIL ENZIM AMILASE
Authors: Mahdiyah Dede
Published: November 2021

Sponges have been known as excellent sources for natural products such asbioactive compounds. Their bioactivities include enzyme inhibitors, cell divisioninhibitors,antiviral, antifungal, antimicrobial, etc. The aims of study were to yielded ofamilase from association sponge Jaspis sp. With bacteria. The bacteria was isolated byusing sea water complete media and to determine amilase toward using soluble starch.Among 136 isolates examined, thirty three isolates yielded amilase.
GAMBARAN STRUKTUR ANATOMIS DAN UJI AKTIVITAS ANTIOKSIDAN DAUN SERTA BATANG Hydroleaspinosa
Authors: Darsono Putri Vidiasari
Published: November 2021

This studyaimed toobserve anatomicalstructure and antioxidant activitiesofleavesand stemsHydroleaspinosa. Anatomical tissues section of leaves and stems wereprepared using paraffin method and analysis of antioxidant activities was done by DPPHmethod (1, 1–difenil–2–pikrilhidrazil). The results showed that the anatomical structureofHydroleaspinosaleavescross sectionconsistsofupperepidermis cells(adaksial)andlowerepidermis cells(abaksial), trichomes, mesophyll that was differentiatedintoabovepalisadeparenchymaandbelow spongyparenchyma, vasculartissues, the strengthenertissuesanddruscrystals. While on thecross sectionofthe stems wereepidermis, cortex,vessels, and pith.There wasairspace between medium stemsand old stems. The resultsofanalytical measurements ofantioxidantactivities onethanolextractofHydroleaspinosaleaves with IC50value 52.735ppm are higher than thestemswithIC50value 68.911ppmbutstill lowerthan the controlof vitaminCandBHT.
SOCIAL ASSISTANT WORK MANAGEMENT IN EDUCATION POLICY
Authors: Quadrado Jaqueline Carvalho , Lima Eduardo
Published: November 2021

The study aimed to understand the importance of the Social Worker work management process in Education Policy, more specifically in the Coordination of Social Work Course. It was questioned whether the theoretical and methodological principles of management apply in the federal public sector, where the work to be carried out already obeys a previously planned and orchestrated agenda by the federal sphere, as it obeys plans and goals established by the managing bodies of policies public. Then, it was asked whether it would be possible to build the theoretical-practical process of management and how to carry it out in the field of professional practice, where the overvaluation of bureaucratic work directly interferes with professional action, a process that contributes to the construction of a practice emptied and uncritical professional. Also in this questioning guideline, it was also asked, what are the theoretical and practical principles of management that the social worker could appropriate as a work tool in his performance in the public sector, where the professional routinely runs into institutional limits and power relations established in the state apparatus. The documentary and bibliographic study was characterized by its exploratory character and qualitative approach. It was considered that the process of valuing bureaucratic work has been gradually encouraging the bureaucratization of practice and the professional void, a fact that conditions professional practice to bureaucratic and routine tasks. Work management and the ability to plan and organize professional action on a purposeful basis become instruments of great importance in the formulation of proposals to face the challenges posed to Social Service professionals.

KEYWORDS: Management; Planning; Education; Social Work; Work.
A GESTÃO DO TRABALHO DO ASSISTENTE SOCIAL NA POLÍTICA DE EDUCAÇÃO
Authors: Quadrado Jaqueline Carvalho , Lima Eduardo
Published: November 2021

O estudo objetivou compreender a importância do processo de gestão do trabalho do Assistente Social na Política de Educação, mais especificamente na Coordenação de Curso de Serviço Social. Questionou-se, se os princípios teóricos e metodológicos da gestão se aplicam no setor público federal, onde o trabalho a ser realizado já obedece a uma agenda previamente planejada e orquestrada pela esfera federal, por obedecer a planos e metas estabelecidas pelos órgãos gestores das políticas públicas. Em seguida, foi questionado, se seria possível construir o processo teórico-prático da gestão e como efetivá-lo no campo de atuação profissional, onde a supervalorização do trabalho burocrático interfere diretamente na ação profissional, processo esse que contribui para a construção de uma prática profissional esvaziada e acrítica. Ainda nesta diretriz de questionamentos, também se perguntou, quais os princípios teóricos e práticos da gestão que o assistente social poderia se apropriar enquanto instrumento de trabalho em sua atuação no setor público, onde o profissional, esbarra rotineiramente nos limites institucionais e nas relações de poder estabelecidas no aparelho estatal. O estudo documental e bibliográfico caracterizou-se por seu caráter exploratório e abordagem qualitativa. Considerou-se que o processo de valorização do trabalho burocrático vem gradativamente estimulando a burocratização da prática e o vazio profissional, fato que condiciona o exercício profissional ao tarefismo burocrático e rotineiro. A gestão do trabalho e a capacidade de planejar e organizar propositivamente a ação profissional tornam-se instrumentos de grande importância na formulação de propostas de enfrentamento aos desafios postos ao profissional de Serviço Social.
JORNALISMO LITERÁRIO AVANÇADO E NARRATIVAS ARTESÃS: sinalizadores para a pesquisa em Turismo
Authors: Eme Jennifer Bauer , Baptista Maria Luiza Cardinale
Published: November 2021

O presente texto tem como objeto de estudo a proposição de entrelaçamento do Jornalismo Literário Avançado (JLA) com a produção de ‘narrativas artesãs’, tendo como objetivo propor sinalizadores para a pesquisa em Turismo. O artigo apresenta o conceito de JLA e a compreensão de Turismo, como Trama-Ecossistêmica de Desterritorialização. Os aspectos metodológicos são compostos pela Cartografia de Saberes. Narrativas artesãs correspondem ao campo de pesquisa, com relatos de histórias de vida de artesãos de rua, entrelaçados com registros pessoais de diário de pesquisa. A produção permite pensar no JLA e as narrativas artesãs como campos de potencialidades, para a brotação de pesquisas que compreendam o Turismo e suas transversalidades, em sua complexidade.
THE NEW CORONAVIRUS AND THE CONSEQUENCES IN THE MENTAL HEALTH OF HEALTH PROFESSIONALS INVOLVED IN THEIR COURSE
Authors: Maciel Érika da Silva , Gotardelo Marcele , Rodrigues Allana Lima Moreira , Quaresma Fernando Rodrigues Peixoto , Barasuol Aldair Martins , Nascimento Ladislau Ribeiro do
Published: November 2021

The disease pandemic caused by the new Coronavirus - SARS-Cov-2 is characterized as one of the biggest international public health problems in recent decades. This study aimed to perform a narrative review of the evidence described on the impact on mental health of health professionals who work in care practice related to Covid-19. The articles showed that the problems faced by health professionals during the pandemic can lead to exhaustion of the team, physical and mental exhaustion, contributing to the development of psychological problems.

 

KEYWORDS: Covid-19; Mental health; Health professionals.
Initial and continuing training of teachers mediating the development of educational practice: a historical-critical analysis
Authors: Sousa Elayna Maria Santos , Marques Eliana de Sousa Alencar
Published: November 2021

The article discusses results of research carried out with the aim of analyzing teachers' meanings about professional training, both initial and continuing. The research is based on the ideas of Vigotski and Espinosa about human development, in which two teachers who work in the municipal public network of Teresina-PI participated. The research instruments were a questionnaire and semi-structured interview. The analysis had the nuclei of meanings as a procedure. The analyzes indicate that, if, on the one hand, in the initial training, the appropriate knowledge helped in the professional development of the teachers, on the other hand, the continuing education has collaborated to keep them in a passive situation in the face of educational demands, because they remain dependent to tell them how to act professionally. The results also indicate that continuing education has the potential to remove teachers from the condition of passivity when it collaborates with the development of the conscience of this professional, in short, with their historical development.
Design And Build Virtual Reality Photography Web-Based To Support Tourism
Authors: Julianto Indri Tri
Published: November 2021

Tourism is the activity of visiting tourist objects for recreational and leisure purposes. Along with developments in the world of technology and information, there is a technology that can be used to promote a tourist attraction called Virtual Reality. Virtual Reality is a technology designed to allow users to interact with a computer-simulated environment. The problem is that there are still very few travel websites that provide this feature. Virtual Reality technology in the world of photography is known as Virtual Reality Photography. Virtual Reality Photography can produce images in 360o, so people can see the image as a whole and as if they were in place when the photographer was taking pictures. The purpose of this research is to design and build a website that provides information for tourists who want to visit tourist objects. The development method used is the Multimedia Development Life Cycle. The output of his research is a Virtual Reality Photography website that provides information in the form of 360o images equipped with location maps and static images. Augmented Reality technology can be applied on this website as a form of information presented as well as Virtual Reality technology.

Keywords— Information, Multimedia, Tourism, Virtual Reality, Web.
Design and Construction of Additional Security Device for House Door Using Arduino Uno Based on Short Message Service
Authors: Wara Yuan Reski , Putri Tri Wahyu Oktaviana
Published: November 2021

Security is a very important aspect of a house. The level of protection and comfort of the house certainly cannot be separated from how good the security system of the house is. The door is used for the main entrance and exit of the house. When the owner of the house is inside, the door can be locked from the inside with the addition of a slop lock on the door. However, if the owner of the house leaves, the door is only locked using a regular key without any additional keys on the inside of the door. So that the door of the house can be opened only by "lockpick" by an irresponsible person. Such problems can be prevented by installing additional security devices on the door of the house that can be controlled to lock the inside of the door and can provide early warning to homeowners through SMS (Short Message Service) notifications on cell phones. The components used in this system are Arduino Uno microcontroller, Servo Motor, Vibration Sensor (SW-420), Buzzer, Magnetic Switch MC-38, and GSM SIM800L V2. The prototype worked well and reach the research’s objective.
The Analysis of Needs for Integrated Science Learning Tools Development for Character Education
Authors: Nugroho Irham , Shalikhah Norma Dewi , Purnanto Arif Wiyat
Published: November 2021

Arah pengembangan perangkat pembelajaran sains saat ini masih belum banyak mengakomodir pembentukan karakter peserta didik SD/MI. Penelitian ini bertujuan untuk menganalisis kebutuhan pengembangan perangkat pembelajaran sains di SD/MI. penelitian ini menggunakan pendekatan diskriptif kualitatif. Pengumpulan data menggunakan teknik kuesioner, observasi, dan wawancara dengan melibatkan 63 guru SD/MI sebagai responden. Penelitian ini menghasilkan tiga temuan penting. Pertama, 57,1% guru menyiapkan perangkat pembelajaran sains. Kedua, 79.0% guru mengintegrasikan aspek-aspek karakteristik. Ketiga, 58,7% guru menyatakan pembelajaran berbasis masalah memberi konstribusi dalam pendidikan karakter. Untuk itu perlu dikembangkannya perangkat pembelajaran sains terintegrasi pendidikan karakter untuk mendukung kegiatan belajar mengajar (KBM) di SD/MI.
ANALISIS ANALISIS KEMAMPUAN BERPIKIR KREATIF SISWA DALAM MENYELESAIKAN SOAL OPEN ENDED PADA MATERI PERSAMAAN DAN PERTIDAKSAMAAN LINEAR SATU VARIABEL
Authors: Rachmawati Yuni Ashari , Widayanti Evi
Published: November 2021

Berpikir kreatif merupakan kemampuan yang dimiliki seseorang dalam mengembangkan gagasan yang berkualitas dan berbeda dengan orang lain serta sesuai dengan tugasnya. Kemampuan berpikir kreatif siswa dapat dilihat melalui pemberian soal open ended. Soal open ended merupakan soal yang mempunyai beberapa jawaban benar dan banyak cara untuk mendapatkan jawaban tersebut. Soal open ended yang telah dikerjakan akan dianalisis berdasarkan indikator kemampuan berpikir kreatif. Sehingga tujuan penelitian ini adalah untuk mengetahui kemampuan berpikir kreatif siswa dalam menyelesaikan soal open ended pada materi persamaan dan pertidaksamaan linear satu variabel. Jenis penelitian ini merupakan penelitian kualitatif. Pada akhir pemberian masalah dilakukan analisis berdasarkan beberapa indikator kemampuan berpikir kreatif. Subjek penelitian ini adalah siswa kelas VII SMP Muhammadiyah 17 Surabaya tahun ajaran 2019/2020 berjumlah 5 subjek. Instrumen penelitian ini menggunakan soal tes berupa soal open ended yang memiliki banyak jawaban benar dan sudah divalidasi oleh dua validator. Berdasarkan analisis yang telah dilakukan pada siswa secara keseluruhan sudah mencapai aspek kelancaran dan elaborasi. Hanya beberapa siswa saja yang mencapai aspek keluwesan dan hanya ada satu siswa yang mencapai aspek kebaruan. Hal ini membuktikan bahwa siswa berkemampuan tinggi pun tidak selalu memenuhi keempat indikator berpikir kreatif.
Detention as the Default: How Greece, with the support of the EU, is generalizing administrative detention of migrants
Authors: Papastergiou Vasilis
Published: November 2021

Putting migrants and asylum seekers into detention for administrative reasons is a common practice in Greece, despite this policy contravening human rights. Greek authorities are using detention and the new EU-funded closed compounds as a way to discourage people from seeking asylum in Europe. Detention, as outlined in Greek law, should only be used as a final resort and only then in specific instances. Detention carries with it not only a financial cost, but also a considerable moral cost. Detention without just cause violates basic human rights, such as freedom of movement, the right to health and the right to family life. Alternatives to detention exist and must be prioritized.
Genome-wide Association Study and Possible Candidate Genes for Root Color and Carotenoid Contents in Japanese Orange Carrot F2 Populations
Authors: Shibaya Taeko , Kuroda Chika , Tsuruoka Hisano , Minami Chiharu , Obara Akiko , Nakayama Shinobu , Fujii Takayoshi , Isobe Sachiko
Published: November 2021

Carrot is a major source of provitamin A in a human diet. Two of the most important traits for carrot breeding are carotenoid contents and root color. To examine genomic regions related to these traits and develop DNA markers for carrot breeding, we performed a genome-wide association study (GWAS) using genome-wide single-nucleotide polymorphisms (SNPs) in two F2 populations, both derived from crosses of orange root carrots bred by a Japanese seed company. The GWAS revealed 21 significant associations, and the physical position of some associations suggested two possible candidate genes. An Orange (Or) gene was a possible candidate for visual color evaluation and the α- and β-carotene contents. Sanger sequencing detected a new allele of Or with an SNP which caused a non-synonymous amino acid substitution. Genotypes of this SNP corresponded to the visual evaluation of root color in another breeding line. A chromoplast-specific lycopene β-cyclase (CYC-B) gene was a possible candidate for the β/α carotene ratio. On CYC-B, five amino acid substitutions were detected between parental plants of the F2 population. The detected associations and SNPs on the possible candidate genes will contribute to carrot breeding and the understanding of carotenoid biosynthesis and accumulation in orange carrots.
A Convolutional Neural Network(CNN) Classification To Identify The Presence of Pores in Powder Bed Fusion Images
Authors: Ansari Muhammad Ayub , Crampton Andrew , Garrard Rebecca , Cai Biao , Attallah Moataz
Published: November 2021

This study focuses on the detection of seeded porosity during metal additive manufacturing by employing convolutional neural networks (CNN). The aim of the study is to demonstrate the application of Machine Learning (ML) in in-process monitoring. Laser Powder Bed Fusion (LPBF) is a selective laser melting technique used to build complex 3D parts. The current monitoring system in LPBF is inadequate to produce safety-critical parts due to the lack of automated processing of collected data. To assess the efficacy of applying ML to defect detection in LPBF by in-process images, a range of synthetic defects have been designed into cylindrical artefacts to mimic porosity occurring in different locations, shapes, and sizes. Empirical analysis has revealed insights into the importance of accurate labelling strategies required for data-driven solutions. Two labelling strategies based on the computer aided design (CAD) file and X-ray computed tomography (XCT) scan data was formulated. A novel CNN was trained from scratch and optimised by selecting the best values of an extensive range of hyper-parameters by employing Hyperband tuner. The accuracy of the model was 90% when trained using a CAD-assisted labelling, and 97% when using XCT-assisted labelling. The model successfully spotted pores as small as 0.2mm. Experiments revealed that balancing the data set improved the model's precision from 89% to 97% and recall from 85% to 97% when compared to training on an imbalanced data set. We strongly believed that the proposed model would significantly reduce post-processing cost and provide a better base model network for transfer learning of future ML models aimed at LPBF micro-defects detection.
High Siglec15 Expression in Triple Negative Breast Cancer Predicts Poor Prognosis
Authors: Zhou Peng , Yang Yun-Song , Liu Xi-Yu , Shao Zhi-Ming , Fan Lei
Published: November 2021

Introduction: Normalization cancer immunotherapy is a new strategy to treat breast cancer. Sialic acid binding Ig-like lectin 15 (Siglec-15) is a new potential target for normalization cancer immunotherapy. In this study, we evaluated the role of Siglec15 in breast cancer and investigated the influence of Siglec15 on the microenvironment of infiltrating immune cells in the cancer.Methods: We performed immunhistochemical staining to analyze Siglet-15 expression in primary invasive breast cancer tissue microarrays. The tissue specimens were from 90 patients. Furthermore, The relationship between Siglec15 and clinicopathological features was analyzed with logistic regression and the Wilcoxon signed-rank test. The association between clinical characteristics and overall survival in the Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) patients was assessed. Results: Immunhistochemical staining of tissue microarrays showed that Siglet-15 had higher expression in breast cancer tissues than those in adject normal tissues. Breast cancer tissues had higher Siglec15 expression than normal tissues. Kaplan-Meier survival analysis suggested that triple negative breast cancer with high Siglec15 expression had poorer survival than those with lower Siglec15 expression (p=0.042). Furthermore, high Siglec15 expression group had low activated dendritic cells, follicular helper T cells, and M1 macrophages. Conclusions: Siglet-15 had high expression in breast cancer tissues. High Siglec15 expression is associated with low activated dendritic cells, follicular helper T cells, and M1 macrophages proportions in breast cancer tissue, and predicts poor prognosis in triple negative breast cancer. Siglec15 expression may be a potential prognostic molecular marker of poor survival in breast cancer.
Prostate Cancer Histopathology Using Label-free Multispectral Deep-UV Microscopy Quantifies Phenotypes of Tumor Aggressiveness and Enables Multiple Diagnostic Virtual Stains
Authors: Soltani Soheil , Ojaghi Ashkan , Qiao Hui , Kaza Nischita , Li Xinyang , Dai Qionghai , Osunkoya Adeboye O , Robles Francisco E
Published: November 2021

Identifying prostate cancer patients that are harboring aggressive forms of prostate cancer remains a significant clinical challenge. Here we develop an approach based on multispectral deep-ultraviolet (UV) microscopy that provides novel quantitative insight into the aggressiveness and grade of this disease, thus providing a new tool to help address this important challenge. We find that UV spectral signatures from endogenous molecules give rise to a phenotypical continuum that provides unique structural insight (i.e., molecular maps or “optical stains") of thin tissue sections with subcellular (nanoscale) resolution. We show that this phenotypical continuum can also be applied as a surrogate biomarker of prostate cancer malignancy, where patients with the most aggressive tumors show a ubiquitous glandular phenotypical shift. In addition to providing several novel “optical stains” with contrast for disease, we also adapt a two-part Cycle-consistent Generative Adversarial Network to translate the label-free deep-UV images into virtual hematoxylin and eosin (H&E) stained images, thus providing multiple stains (including the gold-standard H&E) from the same unlabeled specimen. Agreement between the virtual H&E images and the H&E-stained tissue sections is evaluated by a panel of pathologists who find that the two modalities are in excellent agreement. This work has significant implications towards improving our ability to objectively quantify prostate cancer grade and aggressiveness, thus improving the management and clinical outcomes of prostate cancer patients. This same approach can also be applied broadly in other tumor types to achieve low-cost, stain-free, quantitative histopathological analysis.
Using Telomeric Length Measurements and Methylation to Understand The Karyotype Diversification of Ctenomys Minutus (A Small Fossorial Mammals)
Authors: Matzenbacher Cristina A. , Silva Juliana , Garcia Ana Leticia H. , Kretschmer Rafael , Cappetta Mónica , Oliveira Edivaldo H. Correa , Freitas Thales R. O.
Published: November 2021

The genus Ctenomys has been widely used in karyotype evolution studies due to the variation in their diploid numbers (2n), which range from 2n = 10 to 2n = 70. Ctenomys minutus is characterized by intraspecific variation in diploid number (2n = 42, 46, 48, and 50), which makes it an interesting model to investigate the genomic instability mechanisms that have led to different cytotypes in this species. We aimed to contribute to the knowledge about telomeres’ role in chromosomal instability and global DNA methylation in the genome evolution of C. minutus. This study found that telomere length differs between cytotypes, but only for females (50a<46a,48a,42), although methylation was also higher, no significant difference was shown. It was also shown that young individuals, regardless of cytotype, had the longest telomere and the most methylated DNA, although only the last was statistically significant. Despite this, there is still much to be answered, although new cytotypes seem to have emerged within the distribution of parental cytotypes by the accumulation of different chromosomal rearrangements.
Association of D-Dimer Levels On Admission With Outcomes in Elderly Patients With Chronic Obstructive Pulmonary Disease Exacerbation
Authors: Ma Jinling , Li Chengxin , Gao Meng , Wang Xiujie , He Lei
Published: November 2021

Elevated D-dimer is a reliable prognostic marker for both short-term and long-term survival in patients admitted for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We retrospectively reviewed the data of consecutive patients aged 80 years and older with a primary admission diagnosis of AECOPD between December 2008 and December 2014. A total of 2206 patients were included. The patients were followed up for 30 days. D-dimer levels were higher in non-survivors than in survivors (p < 0.001). Patients with need for MV had higher D-dimer levels than patients without need for MV (p < 0.001). Moreover, a significant correlation between D-dimer level and C-reaction protein (CRP) was found (r = 0.2271, p < 0.001). D-dimer level above 1.66 mg/L as the optimal cutoff level predicted 30-day all-cause mortality with a sensitivity and specificity of 87.6% and 89.1%, respectively. Similarly, D-dimer above 1.33 mg/L predicted 30-day need for MV with a sensitivity and specificity of 89.4% and 82.9%, respectively. Furthermore, Kaplan–Meier event-free survival curves demonstrated that higher D-dimer levels had worse event-free survival. D-dimer could be used as a valuable biomarker to predict both 30-day all-cause mortality and the need for MV in elderly patients admitted for AECOPD.
Default Mode and Fronto-Parietal Network Associations with IQ Development Across Childhood in Autism
Authors: Lee Joshua K , Cho An Chuen Billy , Andrews Derek S , Ozonoff Sally , Rogers Sally J , Amaral David G , Solomon Marjorie , Nordahl Christine Wu
Published: November 2021

Background: Intellectual disability affects approximately one third of individuals with autism spectrum disorder (autism), yet a major unresolved question remains concerning the neurobiology that differentiates autistic individuals with and without intellectual disability. IQ is highly variable during childhood. We previously identified subgroups of autistic children with different trajectories of intellectual development from early childhood (2-3½ yeas) up to middle childhood (9-12 years): (a) Persistently-High: Individuals whose intelligence quotients (IQs) remained in the average or better range during this period, (b) Persistently-Low: Individuals whose IQs remained in the range of intellectual disability (IQ < 70) throughout development, and (c) Changers: Individuals whose IQs began in the range of intellectual disability but increased to the borderline or normal IQ range by middle childhood. In the present research, we sought to identify neurobiology that differentiates these trajectory-defined groups within our autism cohort in two brain networks with established links to intellectual functioning and its impairment in (1) the frontoparietal network (FPN), and (2) the default mode network (DMN). Methods: We conducted multivariate distance matrix regression (MDMR) and effect size analyses to examine the volumes of 22 brain regions (11 regions x 2 hemispheres) within the FPN and 24 (12 regions x 2 hemispheres) within the DMN in 48 Persistently-High (18 female), 108 Persistently-Low (32 female), and 109 Changers (39 female) using structural MRI that had been acquired at baseline, and IQ measurements from up to three time points spanning early to middle childhood (Mean Age Time 1: 3.2 years; Time 2: 5.4 years; Time 3: 11.3 years). FPN and DMN network regions of interest were defined on the basis of the large-scale networks defined in Smith et al., (2009).Results: Changers exhibited different DMN network structure from both Persistently-Low and Persistently-High trajectory groups at baseline, but the Persistently-High did not differ from the Persistently-Low group, suggesting that DMN structure may be an early predictor for change in IQ trajectory across childhood. In contrast, Persistently-High exhibited differences in the FPN from both Persistently-Low and Changers groups at baseline, suggesting a difference related more to concurrent IQ and the absence of intellectual disability. Conclusions: Within autism, DMN structure at baseline may differentiate individuals with persistently low IQ from those with more transitory low IQ that improves to the borderline range or better through early childhood, potentially indicating compensatory mechanisms which may be targeted by future interventions. The brain structure differences between these three IQ-based subgroups may be indicative of distinct neural underpinnings of autism phenotypic subtypes.
Comparison of Objective and Subjective Visual Quality Following LASEK, FS-LASIK and SMILE for Different Myopic Corrections: A Prospective Study
Authors: Liang Gang , Zhou Miao , Pan Chen-Wei
Published: November 2021

Background: To investigate the differences in visual quality after laser epithelial keratomileusis (LASEK), femtosecond laser in situ keratomileusis (FS-LASIK) and small-incision lenticule extraction (SMILE) in different degrees of myopia.Methods: This prospective study incorporated 200 consecutive myopic subjects (200 eyes). Myopia was subdivided into 3 levels based on the preoperative spherical equivalent (SE) value: low myopia (SE ≥ -3.0 D), moderate myopia (−3.0 D > SE ≥ −6.0 D), and high myopia (SE < −6.0 D). Visual quality was recorded and analyzed both objectively using the Optical Quality Analysis System II (OQAS II), and subjectively with uncorrected distance visual acuity (UDVA) and a questionnaire, preoperatively, 1 month and 6 months postoperatively. Results: Six months after LASEK, FS-LASIK and SMILE in myopia, the logarithm of the minimum angle of resolution (LogMAR) UDVA statistically decreased compared with preoperative values (all P < 0.001). While preoperatively, in three surgical procedure groups, objective visual quality parameters demonstrated no significant difference among three degrees of myopia (all P > 0.05), at 6 months postoperatively, after FS-LASIK and SMILE, the modulation transfer function (MTF) cutoff frequency in low myopia was significantly higher than that in high myopia (both P < 0.05). Moreover, intergroup differences in LASEK, FS-LASIK and SMILE groups were not statistically significant, before and 6 months after surgery (all P > 0.05), except that FS-LASIK provided a significantly higher preoperative LogMAR UDVA than SMILE in high myopia (P < 0.05).Conclusion: LASEK, FS-LASIK and SMILE could achieve similar improvement in visual quality to each other after myopia correction. Low myopic patients may achieve better postoperative visual quality after FS-LASIK and SMILE than high myopic patients.Trial registration: This is a prospective study. The study followed the Declaration of Helsinki and was approved by the Institutional Review Board of the Second People’s Hospital of Yunnan Province.