bluuebunny/crossref_metadata_2025 huggingface dataset:
Bodysnatching in the marketplace
Authors: Cronin James , Hopkinson Gillian
Published: November 2017

This article theorizes how market-focused health activism catalyses market change through revealing the ill-effects that consumers’ conformity with market-shaped expectations and ideals has on their bodies and embodied lives. An understanding of this activism is developed by analysing a vicarious form of ‘bodily dys-appearance’ which is used in Jamie Oliver’s televised documentary, Sugar Rush (2015), to narratively provoke corporeal anxieties among audiences. In our analysis, we borrow tropes from the science fiction film, Invasion of the Body Snatchers, to interpret themes centred on a threat, a victim and a hero. We argue that market-focused health activism problematizes the neo-liberal logic of personal responsibility and promotes market intervention as the only means to insulate and safeguard the body from harm. Where extant theorization of consumers’ antagonism towards the market hinges mostly on politically or intellectually motivated resistance, this article demonstrates how somatically oriented concerns operate alternatively to invoke activism.
Joint space tracking control of underwater vehicle-manipulator systems using continuous nonsingular fast terminal sliding mode
Authors: Wang Yaoyao , Chen Bai , Wu Hongtao
Published: November 2017

To ensure satisfactory control performance for the underwater vehicle-manipulator systems, a novel continuous nonsingular fast terminal sliding mode controller is proposed and investigated using time delay estimation in this article. Complex lumped unknown dynamics including the strong nonlinear couplings and external disturbance are properly compensated with time delay estimation, which are mainly based on the time-delayed signals of underwater vehicle-manipulator systems and can provide with a fascinating model-free feature. Afterwards, the satisfactory tracking control performance and good robustness under heavy lumped uncertainties are ensured using the continuous nonsingular fast terminal sliding mode term with a fast terminal sliding mode–type reaching law. Therefore, the proposed controller is easy to use thanks to time delay estimation, and can ensure good control performance owing to continuous nonsingular fast terminal sliding mode. Stability of the closed-loop control system is analyzed using Lyapunov stability theory, and theoretical tracking errors are calculated and presented. Finally, the effectiveness and advantages of the proposed controller are demonstrated through comparative 7-degree-of-freedom pool experiments.
Seeing Myself Through Film: Diasporic Belongings and Racial Identifications
Authors: Oh David C.
Published: November 2017

Through critical autoethnography, I explore memories with film that I have drawn upon to form hybrid diasporic identifications located in “new ethnicities” that are situated between dominant White racial meanings of home and transnationally informed meanings of homeland. Recalling my memory of watching Dragon: The Bruce Lee Story, I recognize that my identification with Bruce Lee (Jason Scott Lee) and his relationship with Linda Lee Caldwell (Lauren Holly) was situated in my desire for White acceptance, which was manifest in my heterosexual romantic interests in White women. I unravel the ways in which racial isolation and a desire for acceptance and visibility created an internalized politics of desire rooted in dominant racial hierarchies. The second narrative examines my viewing of The Last Present, a Korean film, in a Seoul theater. Seeing a love story centered on a romantically involved Asian man in a relationship with an Asian woman, especially a Korean man and woman, was something I had never previously known, and its presence made visible its absence in my mediated life in the United States. This changed my sense of self, my relationship to dominant culture as part of the Korean diaspora, and my sexual and romantic interests. Because I am in the diaspora, my identification is found in what Hall refers to as new ethnicities, situated in the gaps between the local, dominant culture and transnationally received ethnic, homeland culture.
Radiofrequency ablation of osteoid osteoma in the atlas: A case report
Authors: Yang Jun , Li Wei , Yin Yu , Li Zhi , Ni Caifang
Published: November 2017

Osteoid osteoma of the atlas has previously been reported very rarely in the published literature. The traditional standard treatment has been a surgical resection of the nidus. Recently, computed tomography (CT)-guided radiofrequency ablation (RFA) has gained favor as a more precise alternative treatment. Here, we present a case of osteoid osteoma of the C1 lateral mass treated successfully using CT-guided RFA. A 30-year-old woman who presented with a four-month history of occipital and suboccipital pain was treated by CT-guided RFA. The visual analog scale (VAS) assessed the pain before and after RFA. The patient reported significant pain relief and normal activities. The VAS score reduced from 8/7 to 1/0 after the procedure. Therefore CT-guided percutaneous RFA of C1 vertebral osteoid osteoma is a safe and effective method. The technique might be contraindicated when the nidus is less than 2 mm away from the neural structures.
Parental satisfaction with early intensive behavioral intervention
Authors: Grey Ian , Coughlan Barry , Lydon Helena , Healy Olive , Thomas Justin
Published: November 2017

Research related to parental satisfaction with early intensive behavioral intervention (EIBI) remains limited. A 35-item questionnaire called the parental satisfaction scale–EIBI (PSS-EIBI) was developed with four subdomains (child outcomes, family outcomes, quality of the model, and relationship with the team). Study 1 assessed levels of satisfaction for 48 parents with their child’s EIBI program after approximately 1 year of intervention. Study 2 examined the relationship between parental satisfaction, length of child participation in EIBI, and the relationship between parental satisfaction and actual outcomes for their child as assessed by the Verbal Behavior Milestones Assessment and Placement Program after approximately 2 years. Results indicate that parental satisfaction with EIBI was consistently high in all four domains of the PSS-EIBI in both studies. Parental satisfaction was found to be associated with gains in child functioning after 1 year of intervention.
How to make Lesson Study work in America and worldwide: A Japanese perspective on the onto-cultural basis of (teacher) education
Authors: Rappleye Jeremy , Komatsu Hikaru
Published: November 2017

Lesson Study is a Japanese approach to teacher development borrowed by American researchers in the late 1990s seeking to break from top-down, “best practice” approaches. Two decades later, Lesson Study has gained a strong foothold in American policy circles. Seeking to contribute to the growing research base, this article looks deeper into the cultural obstacles obstructing effective practice in the American context. It suggests that the divergent onto-cultural basis of the Japanese context may be one major factor that helps make Lesson Study successful in Japan but challenging in other national contexts worldwide, perhaps most of all in the United States. The account is based on a meta-analysis of existing research on Lesson Study (1999–2015), combined with a reconceptualization of a rich ethnographic literature on compulsory schooling in Japan. This account frames the American borrowing of Japanese teacher developed practice in terms of educational borrowing and lending, suggesting that scholars need to return to the puzzle of culture, engage philosophically, and be open to ontological alterity.
Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion
Authors: Alemseged Fana , Shah Darshan G , Bivard Andrew , Kleinig Timothy J , Yassi Nawaf , Diomedi Marina , Di Giuliano Francesca , Sharma Gagan , Drew Roy , Yan Bernard , Dowling Richard J , Bush Steven , Sallustio Fabrizio , Caltagirone Carlo , Mercuri Nicola B , Floris Roberto , Parsons Mark W , Levi Christopher R , Mitchell Peter J , Davis Stephen M , Campbell Bruce CV
Published: November 2017

Background

CT perfusion may improve diagnostic accuracy in posterior circulation stroke. The posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) on Computed Tomography Angiography source images (CTA-SI) predicts functional outcome in patients with basilar artery occlusion.

Aims

We assessed the prognostic value of pc-ASPECTS on CT perfusion in patients with vertebral and basilar artery occlusion (VBAO) in comparison with CTA-SI.

Methods

Whole-brain CT perfusion from consecutive stroke patients with VBAO at four stroke centers was retrospectively analyzed. pc-ASPECTS – a 10-point score assessing hypoattenuation on CTA-SI – was calculated from CT perfusion parameters as focally reduced cerebral blood flow or cerebral blood volume, focally increased time to peak of the deconvolved tissue residue function (Tmax) or mean transit time. Two investigators independently reviewed the images. Reliability was assessed with intraclass correlation coefficient. Good outcome was defined as modified Rankin scale ≤3 at three months.

Results

We included 60 patients with VBAO. After assessment of four CT perfusion maps simultaneously, area-under-ROC curve (AROC) was 0.83 (95%CI 0.72–0.93) for cerebral blood volume, 0.76 (95%CI 0.64–0.89) for cerebral blood flow, 0.77 (95%CI 0.64–0.89) for Tmax, 0.70 (95%CI 0.56–0.84) for mean transit time versus area-under-ROC curve 0.64 (95%CI 0.50–0.79) for CTA-SI. Cerebral blood volume had greater accuracy compared with CTA-SI for poor outcome (p = 0.04). In logistic regression analysis, cerebral blood volume pc-ASPECTS≤8 was independently associated with poor outcome (OR 9.3 95%CI 2.2–41; p = 0.003, adjusted for age and clinical severity). Inter-rater agreement was substantial for cerebral blood volume pc-ASPECTS (intraclass correlation coefficient 0.82 95%CI 0.71–0.90 versus 0.67 for CTA-SI 95%CI 0.43–0.81).

Conclusions

Cerebral blood volume pc-ASPECTS may identify VBAO patients at higher risk of disability.
Is college education an equalizer for social disparities in health literacy? A case study in Shanghai, China
Authors: Hu Anning , Yang Xiaozhao Yousef
Published: November 2017

Objectives:

The aim of the study was to illustrate the immediate effect of the college education process (across college grades) on the strength of association between parental education and college attendees’ health literacy.

Methods:

Cross-sectional analysis was conducted based on data from a random sample of students in one university in Shanghai, China ( N = 574). Exploratory factor analysis was used to generate factors of different dimensions of health literacy. Ordinary least square regression models were estimated to investigate how college education process alters the family-based disparity in health literacy.

Results:

The link between parental education and health-related skills did not vary significantly across grades of participants, but participants in their third ( p < 0.05) and fourth year ( p < 0.001) revealed a significantly weaker association between health-promoting proactivity and parental education, relative to the first-year counterparts. Also, the impact of parental education on health-related attitudes significantly declined among the fourth-year seniors, compared with first-year students ( p < 0.05).

Conclusions:

Higher education experience is an important mechanism to alleviate the socioeconomic gap in health literacy. Such an equalizer effect, nevertheless, is contingent on the particular dimensions of health literacy.
The Attitudinal and Behavioral Impact of School Law Courses
Authors: Decker Janet R. , Ober Patrick D. , Schimmel David M.
Published: November 2017

Although past research has documented that school leaders and teachers lack legal knowledge, this study is the first to ask the critical question whether legal training affects educators’ actions and attitudes. School leaders and teachers responded to a survey in the years after completing a graduate-level school law course. They indicated that the course empowered them to solve legal dilemmas. Specifically, 88% reported that this legal training increased their confidence and 85% indicated that the course altered their behaviors. They encountered numerous legal issues, but prior to the course, they received little legal training and had limited access to legal advice.
Peripheral Visual Cues Contribute to the Perception of Object Movement During Self-Movement
Authors: Rogers Cassandra , Rushton Simon K. , Warren Paul A.
Published: November 2017

Safe movement through the environment requires us to monitor our surroundings for moving objects or people. However, identification of moving objects in the scene is complicated by self-movement, which adds motion across the retina. To identify world-relative object movement, the brain thus has to ‘compensate for’ or ‘parse out’ the components of retinal motion that are due to self-movement. We have previously demonstrated that retinal cues arising from central vision contribute to solving this problem. Here, we investigate the contribution of peripheral vision, commonly thought to provide strong cues to self-movement. Stationary participants viewed a large field of view display, with radial flow patterns presented in the periphery, and judged the trajectory of a centrally presented probe. Across two experiments, we demonstrate and quantify the contribution of peripheral optic flow to flow parsing during forward and backward movement.
Trigger Features for Conveying Facial Expressions: The Role of Segmentation
Authors: Ramachandran Vilayanur S , Chunharas Chaipat , Smythies Michael
Published: November 2017

Primates are especially good at recognizing facial expression using two contrasting strategies—an individual diagnostic feature (e.g., raise eyebrows or lower mouth corner) versus a relationship between features. We report several novel experiments that demonstrate a profound role of grouping and segmentation—including stereo—on recognition of facial expressions.
Selfie-taking motives and social psychological dispositions as predictors of selfie-related activities among university students in Kuwait
Authors: Al-Kandari Ali A. , Abdelaziz Yasser Abuelmakarem
Published: November 2017

This study explores motives for taking and posting selfies on social media and whether those motives and other social psychological dispositions predict the selfie-related activities of “taking,” “posting,” and “editing” selfies. A sample of 404 university students in Kuwait indicated they took and posted selfies for motives of appraisal-seeking self-presentation (ASSP), entertainment, status-updating self-presentation (SUSP) and documentation. Females were more likely to be involved in selfie-related activities and to use selfies for ASSP. Documentation was the prime predictor of the activity of “taking” selfies, SUSP was for “posting” selfies, and ASSP was for “editing” selfies. Self-perceived attractiveness predicted the activities of “posting” and “taking” selfies. Results are discussed in light of the influence of culture in Kuwait and some conceptual considerations about selfies are made.
X-linked adult-onset adrenoleukodystrophy: Psychiatric and neurological manifestations
Authors: Shamim Daniah , Alleyne Karen
Published: November 2017

Adult-onset adrenoleukodystrophy is a rare x-linked inborn error of metabolism occurring predominantly in males with onset in early 30s. Here, we report a 34-year-old male with first signs of disease in early 20s manifesting as a pure psychiatric disorder. Prior to onset of neurological symptoms, this patient demonstrated a schizophrenia and bipolar-like presentation. The disease progressed over the next 10–13 years and his memory and motor problems became evident around the age of 33 years. Subsequently, diagnostic testing showed the typical magnetic resonance imaging and lab findings for adult-onset adrenoleukodystrophy. This case highlights adult-onset adrenoleukodystrophy which may present as a pure psychiatric disturbance in early adulthood and briefly discusses the prolonged time between the onset of psychiatric symptoms and the onset of neurological disease.
Accountability for Sustainable Development and the Challenges of Leadership in Nigeria, 1999-2015
Authors: Gberevbie Daniel , Joshua Segun , Excellence-Oluye Nchekwube , Oyeyemi Adeola
Published: November 2017

Development of any society is meant to enhance the living standard of citizens. However, where there are challenges of accountability, development is more likely to be a mirage. Past studies in Nigeria on the challenges of leadership and sustainable development identified corruption and lack of required skills on the part of public officials to perform in terms of proper policy formulation and implementation among others. The main goal of this article is to explore the relationship between accountability for the sustainable development and the challenges of leadership in Nigeria. With the analysis of data obtained from secondary sources, this present study identified lack of accountability for sustainable development to include the challenges leadership, unethical behavior, poor maintenance culture, poor management of resources, corruption on the part of public officials, and inadequate funds to execute projects in Nigeria. This article therefore recommends, among others, the need for government to adopt a more practical approach to the promotion of accountability, a determined fight against corruption and unethical behavior, proper management of resources, and devotion of more funds to the execution of capital projects that could positively affect the lives of the people for improved standard of living.
The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and Treatment
Authors: Goodwin C. Rory , Ahmed A. Karim , Boone Christine , Abu-Bonsrah Nancy , Xu Risheng , Germscheid Niccole , Fourney Daryl R. , Clarke Michelle , Laufer Ilya , Fisher Charles G. , Bettegowda Chetan , Sciubba Daniel M.
Published: November 2017

Study Design:

Systematic review.

Objectives:

The objective of this systematic review was to answer 2 key questions: (1) What is the clinical presentation and probability of symptomatic improvement following treatment for patients with renal cell carcinoma (RCC) of the spine? (2) What is the overall survival of patients diagnosed with spinal metastases from RCC?

Methods:

A literature review was performed to identify articles that reported on survival, clinical outcomes, and/or prognostic factors in the RCC population with spinal metastases from 1986 to 2016.

Results:

Forty-eight articles (807 patients) were included. The Fuhrman Nuclear Grade has been significantly associated with survival in previous studies but was underpowered in the current study. The Memorial Sloan-Kettering Cancer Center Score (MSKCC/Motzer) was also underpowered in the current study. From the time of spinal metastasis, the mean and median survival for patients with previously diagnosed primary RCC was 8.75 and 11.7 months, respectively, whereas synchronously diagnosed patients (primary RCC and spinal metastasis) had a mean and median survival of 6.75 and 11 months, respectively. Patients with a “low” (0-8), “intermediate” (9-11), or “high” (12-15) revised Tokuhashi score at initial presentation had a median survival of 5.4, 11.7, and 32.9 months, respectively.

Conclusion:

Patients with either a synchronous or latent diagnosis of RCC survived greater than 6 months from the time of presentation. Initial Furhman grade, Tokuhashi score, and MSKCC/Motzer can be useful tools in informing patient-specific prognosis for those with metastatic RCC of the spine.
Monopoly Regulation Under Relaxed Pareto Efficiency
Authors: Saglam Ismail
Published: November 2017

Baron and Myerson (BM; 1982, Econometrica, 50(4), 911–930) propose an incentive-compatible, individually rational and ex ante socially optimal direct-revelation mechanism to regulate a monopolistic firm with unknown costs. Their mechanism is not ex post Pareto dominated by any other feasible direct-revelation mechanism. However, there also exist an uncountable number of feasible direct-revelation mechanisms that are not ex post Pareto dominated by the BM mechanism. To investigate whether the BM mechanism remains in the set of ex post undominated mechanisms when the Pareto axiom is slightly weakened, we introduce the ∈-Pareto dominance. This concept requires the relevant dominance relationships to hold in the support of the regulator’s beliefs everywhere except for a set of points of measure ∈, which can be arbitrarily small. We show that a modification of the BM mechanism which always equates the price to the marginal cost can ∈-Pareto dominate the BM mechanism at uncountably many regulatory environments, while it is never ∈-Pareto dominated by the BM mechanism at any regulatory environment.
Punishment, Religion, and the Shrinking Welfare State for the Very Poor in the United States, 1970–2010
Authors: Shannon Sarah K. S.
Published: November 2017

The U.S. social safety net for the very poor has been shrinking for several decades. Two factors stand out as potential drivers of this transformation: a neoliberal turn in poverty governance that favors incarceration and other punitive policies and “religious neoliberalism,” which melds neoliberal, anti-statist political ideology with conservative Christian ideals of compassionate assistance administered not by government but through local congregations. Yet these two streams have not been studied simultaneously in relation to welfare retrenchment. Analysis of the demise of state General Assistance (GA) programs using Cox regression models and a unique longitudinal data set shows that higher incarceration rates and higher church density both contribute to the decline of public assistance over time. Findings support the theoretical perspective of religious neoliberalism.
Changes in bone marrow innate lymphoid cell subsets in monoclonal gammopathy: target for IMiD therapy
Authors: Kini Bailur Jithendra , Mehta Sameet , Zhang Lin , Neparidze Natalia , Parker Terri , Bar Noffar , Anderson Tara , Xu Mina L. , Dhodapkar Kavita M. , Dhodapkar Madhav V.
Published: November 2017

Key Points

Altered number, subset composition, and function of bone marrow innate lymphoid cells are early events in monoclonal gammopathies. Pomalidomide therapy leads to reduction in Ikzf1 and Ikzf3 and enhanced human innate lymphoid cell function in vivo.
Some generalizations for $(\alpha - \psi,\phi )$-contractions in b-metric-like spaces and an application
Authors: Zoto Kastriot , Rhoades B. E. , Radenović Stojan
Published: November 2017

In this paper, we introduce a new class of $\alpha_{qs^{p}}$

α

q

s
p

-admissible mappings and provide some fixed point theorems involving this class of mappings satisfying some new conditions of contractivity in the setting of b-metric-like spaces. Our results extend, unify, and generalize classical and recent fixed point results for contractive mappings.
Random semilinear system of differential equations with impulses
Authors: Baliki A , Nieto JJ , Ouahab A , Sinacer ML
Published: November 2017

In this paper, we study the existence of solutions for systems of random semilinear impulsive differential equations. The existence results are established by means of a new version of Perov’s, a nonlinear alternative of Leray-Schauder’s fixed point principles combined with a technique based on vector-valued metrics and convergent to zero matrices. Also, we give a random abstract formulation to Sadovskii’s fixed point theorem in a vector-valued Banach space. Examples illustrating the results are included.
Model-based redatuming of seismic data: An inverse-filter approach
Authors: Planès Thomas , Snieder Roel , Singh Satyan
Published: November 2017

Standard model-based redatuming techniques allow focusing of the direct waves at the new datum, but the focus can be degraded because of surface multiples and internal multiples in the overburden. We demonstrate that if the medium above the redatuming level is known, these multiples can be correctly handled. We compute the exact focusing functions, free of multiples, using an inverse-filter approach. These focusing functions create downward-radiating and upward-radiating virtual sources at the new datum. The surface responses to these virtual sources are then used to compute the objective redatumed data set through multidimensional deconvolution. The redatumed data set corresponds to a virtual acquisition made at the new datum and for which the imprint of the overburden is completely removed. We test the technique on 2D acoustic synthetic examples corresponding to a seismic context and an acoustic nondestructive testing context.
Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase
Authors: Locke Clifford , Machida Kazuya , Wu Yi , Yu Ji
Published: November 2017

Erythropoietin-producing hepatocellular (Eph) receptors regulate a wide array of developmental processes by responding to cell-cell contacts. EphB2 is well-expressed in brain and known to be important for dendritic spine development, as well as for the maintenance of the synapses, although the mechanisms of these functions have not been fully understood. Here we studied EphB2's functions in hippocampal neurons with an optogenetic approach, which allows us to specify spatial regions of signal activation and monitor in real-time the consequences of signal activation. We designed and constructed OptoEphB2, a genetically encoded photoactivatable EphB2. Photoactivation of OptoEphB2 in fibroblast cells induced receptor phosphorylation and resulted in cell rounding – a well-known cellular response to EphB2 activation. In contrast, local activation of OptoEphb2 in dendrites of hippocampal neurons induces rapid actin polymerization, resulting dynamic dendritic filopodial growth. Inhibition of Rac1 and CDC42 did not abolish OptoEphB2-induced actin polymerization. Instead, we identified Abelson Tyrosine-Protein Kinase 2 (Abl2/Arg) as a necessary effector in OptoEphB2-induced filopodia growth in dendrites. These findings provided new mechanistic insight into EphB2's role in neural development and demonstrated the advantage of OptoEphB as a new tool for studying EphB signaling.
Krox20 defines a subpopulation of cardiac neural crest cells contributing to arterial valves and bicuspid aortic valve
Authors: Odelin Gaëlle , Faure Emilie , Coulpier Fanny , Di Bonito Maria , Bajolle Fanny , Studer Michèle , Avierinos Jean-François , Charnay Patrick , Topilko Piotr , Zaffran Stéphane
Published: November 2017

Although cardiac neural crest cells are required at early stages of arterial valve development, their contribution during valvular leaflet maturation remains poorly understood. Here, we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of Krox20-expressing neural crest cells shows a large contribution to the borders and the interleaflet triangles of the arterial valves. Loss of Krox20 function results in hyperplastic aortic valve and partially penetrant bicuspid aortic valve formation. Similar defects are observed in neural crest Krox20-deficient embryos. Genetic lineage tracing in Krox20−/− mutant mice shows that endothelial-derived cells are normal, whereas neural crest-derived cells are abnormally increased in number and misplaced in the valve leaflets. In contrast, genetic ablation of Krox20-expressing cells is not sufficient to cause an aortic valve defect, suggesting that adjacent cells can compensate this depletion. Our findings demonstrate a crucial role for Krox20 in arterial valve development and reveal that an excess of neural crest cells may be associated with bicuspid aortic valve.
HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis
Authors: Desgrange Audrey , Heliot Claire , Skovorodkin Ilya , Akram Saad U. , Heikkilä Janne , Ronkainen Veli-Pekka , Miinalainen Ilkka , Vainio Seppo J. , Cereghini Silvia
Published: November 2017

Kidney development depends crucially on proper ureteric bud branching giving rise to the entire collecting duct system. The transcription factor HNF1B is required for the early steps of ureteric bud branching, yet the molecular and cellular events regulated by HNF1B are poorly understood. We report that specific removal of Hnf1b from the ureteric bud leads to defective cell-cell contacts and apicobasal polarity during the early branching events. High-resolution ex vivo imaging combined with a membranous fluorescent reporter strategy show decreased mutant cell rearrangements during mitosis-associated cell dispersal and severe epithelial disorganization. Molecular analysis reveals downregulation of Gdnf-Ret pathway components and suggests that HNF1B acts both upstream and downstream of Ret signaling by directly regulating Gfra1 and Etv5. Subsequently, Hnf1b deletion leads to massively mispatterned ureteric tree network, defective collecting duct differentiation and disrupted tissue architecture, which leads to cystogenesis. Consistently, mRNA-seq analysis shows that the most impacted genes encode intrinsic cell-membrane components with transporter activity. Our study uncovers a fundamental and recurring role of HNF1B in epithelial organization during early ureteric bud branching and in further patterning and differentiation of the collecting duct system in mouse.
FOX and ETS family transcription factors regulate the pigment cell lineage in planarians
Authors: He Xinwen , Lindsay-Mosher Nicole , Li Yan , Molinaro Alyssa M. , Pellettieri Jason , Pearson Bret J.
Published: November 2017

Many pigment cells acquire unique structural properties and gene expression profiles during animal development. The underlying differentiation pathways have been well characterized in cells formed during embryogenesis, such as the neural crest-derived melanocyte. However, much less is known about the developmental origins of pigment cells produced in adult organisms during tissue homeostasis and repair. Here we report a lineage analysis of ommochrome- and porphyrin-producing cells in the brown, freshwater planarian Schmidtea mediterranea. Using an RNA-sequencing approach, we identified two classes of markers expressed in sequential fashion when new pigment cells are generated during regeneration or in response to pigment cell ablation. We also report roles for FOXF-1 and ETS-1 transcription factors, as well as for an FGFR-like molecule, in the specification and maintenance of this cell type. Together, our results provide insights into mechanisms of adult pigment cell development in the strikingly colorful Platyhelminthes phylum.
Cohesin facilitates zygotic genome activation in zebrafish
Authors: Meier Michael , Grant Jenny , Dowdle Amy , Thomas Amarni , Gerton Jennifer , Collas Philippe , O'Sullivan Justin M. , Horsfield Julia A.
Published: November 2017

At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear architectural proteins cohesin and CCCTC-binding factor (CTCF) contribute to chromatin structure and gene regulation. We show here that normal cohesin function is important for ZGA in zebrafish. Depletion of the cohesin subunit Rad21 delays ZGA without affecting cell cycle progression. In contrast, CTCF depletion has little effect on ZGA, whereas complete abrogation is lethal. Genome-wide analysis of Rad21 binding reveals a change in distribution from pericentromeric satellite DNA and other locations, including the miR-430 locus (the products of which are responsible for maternal transcript degradation), to genes, as embryos progress through the MZT. After MZT, a subset of Rad21 binding overlaps the pioneer factor Pou5f3, which activates early expressed genes. Rad21 depletion disrupts the formation of nucleoli and RNA polymerase II foci, suggestive of global defects in chromosome architecture. We propose that Rad21/cohesin redistribution to active areas of the genome is key to the establishment of chromosome organization and the embryonic developmental program.
Identification of organic pigments in tattoo inks and permanent make-ups using MALDI-TOF mass spectrometry
Authors: Niederer Markus , Hauri Urs , Kroll Lydia , Hohl Christopher
Published: November 2017

Nowadays, about 12% of the European and 20% of the US population are tattooed. Rising concerns regarding consumer safety, led to legal restrictions on tattoo inks and permanent make-up (PMU) inks. Restrictions also include bans on certain hazardous colourants. Both ink types use organic pigments for colour-giving, plus inorganic pigments for white and black and colour tones. Pigments are only sparingly soluble in common solvents and occur as suspended particles in the ink matrix. Their detection and identification therefore pose a major challenge for laboratories involved in monitoring the legal compliance of tattoo inks and PMUs. We overcame this challenge by developing a matrix-assisted laser desorption ionisation time-of-flight mass spectrometry method, which included an easy sample clean up. The method proved to be capable of detecting and identifying organic pigments in almost all of the tested ink samples. Method validation and routine deployment during market surveys showed the method to be fit for purpose. Pigment screening of 396 tattoo inks and 55 PMUs taken from the Swiss market between 2009 and 2017 lead to the following conclusions: Pigment variety is much greater in tattoo inks (18) than in PMUs (10); four prohibited pigments (Pigment Green 7, Pigment Red 122, Pigment Violet 19 and 23) were found in both ink types; for PMUs, these four pigments made up 12% of the pigment findings, compared to 32% for tattoo inks. Therefore, legal compliance of PMUs was at a higher level. A comparison of pigments found with those declared on tattoo ink labels clearly showed that banned pigments are rarely declared, but rather masked by listing not present legal pigments and label forging; therefore, highlighting the urgency of widespread market controls.
Reconceptualizing Family-Professional Partnership for Inclusive Schools: A Call to Action
Authors: Haines Shana J. , Francis Grace L. , Mueller Tracy Gershwin , Chiu Chun-Yu , Burke Meghan M. , Kyzar Kathleen , Shepherd Katharine G. , Holdren Natalie , Aldersey Heather M. , Turnbull Ann P.
Published: November 2017

Despite the documented link between the presence of family-professional partnership and successful inclusion in schools, these trusting relationships are more of an exception than a reality. We demonstrate the need for a framework to organize research, policy, and practice on family-professional partnership; describe a contemporary framework, the Sunshine Model, that relies on a tiered and multidimensional approach to ensure family-professional partnership with all families; and illustrate how this framework can guide research, policy, and practice in family-professional partnership in inclusive schools.
The curator’s sketchbook: Reflections on learning to see
Authors: Mida Ingrid
Published: November 2017

This paper advocates for the use of drawing as an interdisciplinary research tool and argues in favour of drawing as a method by which to improve the observation and reading of artefacts. I suggest that the process of drawing, in slowing down the process of looking, can facilitate close observation of artefacts and thereby help to reveal subtle clues and hidden narratives. I call this method of attentive looking The Slow Approach to Seeing. The genesis of that idea and its extension as a pedagogic tool are described herein. This methodological position is supported with reference to John Ruskin, John Berger and James Elkins.
First steps towards a model of style grammar in drawing
Authors: Sweo Jennie
Published: November 2017

A process for identifying key elements that make up a drawing style would make it much easier to teach drawing students how to borrow critical elements from experienced artists and art connoisseurs’ different ways to see drawings. This paper starts developing a model of style grammar in drawing. A comprehensive literature review suggests line length, width and expressiveness, local and global tone, pattern and depth as expressed through form, outline, shape or object position are likely to be the most important traits to a drawing style. To test and validate the list based on human perception, a multidimensional scaling card sorting procedure was employed. Quantitative estimates of the visual features produced four dimensions; smudge, depth, tone and line expressiveness. Future statistical analysis may prove that the four identified dimensions will provide significance for comparison measures of style that can guide the development of a rule set for intelligent borrowing and design reuse.
There is drawing and there is laughter
Authors: Hewish Andrew
Published: November 2017

An examination of the artist/cartoonist David Shrigley’s work through the prism of philosopher Simon Critchley’s writing reveals a melancholic space of play where humour and obliquity allows the difficult but necessary expression of the unspeakable. A historical overview of melancholy and a close reading of the philosophical and psychoanalytical subtexts of humour in and through drawing opens up a reading of Shrigley’s work illuminated by the triad of nihilism, humour and a long historical strain of melancholy. Critichley, whose work on humour sits within the larger context of his work on nihilism, expands from Freud on melancholy and humour to articulate a self that is constituted as a mournful melancholic. Shrigley’s manipulations of the tropes of drawing produce a wistful ironic distance equivalent to Critchley’s self that ‘smiles and finds ourselves ridiculous in our own impossible mourning’. Shrigley’s work explodes this state towards materialism, immateriality and loss apposite to the work of Benjamin, Derrida and Agamben.
AVALIAÇÃO DO PERFIL DE ÁCIDOS GRAXOS DE QUEIJO TIPO CHEVROTIN SIMBIOTICO
Authors: Beltrao Fabiana Augusta Santiago , Moura Carla Veronica Rodarte de , Madruga Martha Suely , Andrade Annie Elisabeth Beltrao de
Published: November 2017

Alimentos com bactérias probióticas ou prebióticos estão incluídos na categoria de alimentos contendo compostos bioativos que tem despertado interesse devido ao efeito benéfico para a saúde. O objetivo deste estudo foi avaliar o efeito da produção de queijos tipo “chevrotin” de leite caprino, bovino e misto com a utilização de um prebiótico (inulina), associados à utilização de um probiótico, a bactéria Bifidobacterium lactis. Foram utilizados nove queijos, alocados em um delineamento inteiramente casualizado, com fatorial (3x3), em três tipos de leite e três níveis de inulina (0%, 2,5% e 5,0%). De acordo com os resultados, os percentuais de ácidos graxos saturados (AGS), a concentração dos ácidos monoinsaturados (MUFA) e a concentração dos ácidos polinsaturados (PUFA) aumentaram linearmente (p < 0,01). Foram identificados trinta ácidos graxos, dentre estes 17 saturados, nove monoinsaturados e quatro poliinsaturados. A composição dos ácidos graxos nos diferentes tipos de queijos apresentou maior teor de ácidos graxos monoinsaturados e poliinsaturados nos queijos caprinos e misto e maior teor de ácidos graxos saturados nos queijos com leite bovino.
REAÇÃO DE MAILLARD: UMA REVISÃO
Authors: Francisquini Júlia D'Almeida , Martins Evandro , Silva Paulo Henrique Fonseca , Schuck Pierre , Perrone Ítalo Tuler , Carvalho Antônio Fernandes
Published: November 2017

A reação de Maillard é um importante tema de estudo em ciência e tecnologia de alimentos e diferentes áreas do conhecimento estão integradas como química, engenharia de alimentos, nutrição e tecnologia de alimentos. O objetivo deste artigo é apresentar os conceitos envolvidos na reação de Maillard levando em conta as etapas da reação, os principais produtos e algumas consequências tecnológicas para os produtos lácteos.
Carcass and Meat Quality of Male and Female Water Buffaloes Finished Under an Intensive Production System
Authors: Ekiz Bulent , Yilmaz Alper , Yalcintan Hulya , Yakan Akin , Yilmaz Ismail , Soysal Ihsan
Published: November 2017

Carcass and meat quality of male and female Anatolian water buffaloes were investigated using 10 carcasses from each gender. Gender had no influence on carcass characteristics, except warm carcass weight, which was 13% higher in males compared to females. Meat from male water buffaloes had higher ultimate pH and lightness (L*), but lower redness (a*) values than females. Meat samples aged for 21 days had lower values for expressed juice, cooking loss and Warner Bratzler shear force compared with those of 7-day aged ones. Meat samples aged for 21 days had higher L* value at 1 h and 24 h after cutting, a* value at 1 h after cutting compared with those of 7-day aged meat samples. Gender had no effect on meat sensory characteristics. Meat from male water buffaloes had higher proportions of C14:0, C18:3 n-3, C20:2 n-6, C20:3 n-3 and C20:4 n-6 and Σn-3 fatty acids and lower Σn-6/Σn-3 ratio compared with female water buffaloes.
Analysis of Woven Fabric at the Place of the Sewn Seam
Authors: Rogina-Car Beti , Schwarz Ivana , Kovačević Stana
Published: November 2017

Key importance and the role of sewn seam in the woven fabric are presented. Fabric properties in the places joined with the sewn seam on which garment durability, applicability, appearance and quality depend are highlighted. Seam location is usually the weakest spot on the garment, especially when the great loads are present at these places. Mechanical properties of the sewn fabrics were investigated in different test conditions. The influence of the load on the sewn seam is analyzed in time intervals. Sample with seam have approximately 70% lower breaking properties (breaking force and elongation at break) than the sample without seam. By preloading the seam fabrics with 30%, 50% and 70% of elongation at break, for a 3-h period, the effect on mechanical properties were tested and the differences in pre-stretching intensity were observed. By conducting such test, it is expected that the fabric experience further degradation and that breaking properties further reduce, but the exact opposite occurred (breaking properties, by increasing the preload, increase even more), because of various material properties (structural fabric properties, raw material characteristics, seam characteristics).
Development concepts of a Smart Cyber Operating Theater (SCOT) using ORiN technology
Authors: Okamoto Jun , Masamune Ken , Iseki Hiroshi , Muragaki Yoshihiro
Published: November 2017

Currently, networking has not progressed in the treatment room. Almost every medical device in the treatment room operates as a stand-alone device. In this project, we aim to develop a networked operating room called “Smart Cyber Operating Theater (SCOT)”. Medical devices are connected using Open Resource interface for the Network (ORiN) technology. In this paper, we describe the concept of the SCOT project. SCOT is integrated using the communication interface ORiN, which was originally developed for industry. One feature of ORiN is that the system can be constructed flexibly. ORiN creates abstracts of the same type of devices and increases the robustness of the system for device exchange. By using ORiN technology, we are developing new applications, such as decision-making navigation or a precision guided treatment system.
Robust Cascade Control for Chemical Reactors: An Approach based on Modelling Error Compensation
Authors: Romero-Bustamante Jorge A , Moguel-Castañeda Jazael G , Puebla Hector , Hernandez-Martinez Eliseo
Published: November 2017

In this work, a robust model-based cascade control scheme for composition regulation in chemical reactors is proposed. The controller is based on a two loop control in a composition-temperature configuration. State-observers are introduced to provide robustness to the controller via the estimation of lumped model uncertainties. The second loop is introduced with a favorable choice of the Arrhenius equation as a virtual control input. The control design is illustrated based on two cases studies, a tubular reactor exhibiting two temperature dynamics (quasi-linear and hot-spot) and a CSTR presenting multiple steady-states. Numerical results indicate that proposed controller is robust in the face of external disturbances, operation changes, and model uncertainties.
Obligations to Reduce Emissions: From the Oslo Principles to Enterprises
Authors: Sutherland Philip
Published: November 2017

The release of Greenhouse Gases (GHGs) by the activities of humans is a major contributor to current global climate change. A major environmental catastrophe caused by this climate change will be averted only if the emission of GHGs are drastically reduced. Attempts have been made to reach international agreements among nations to achieve this, but these attempts, of which the Paris Agreement is the most recent, appear to be inadequate and ineffective. A group of scholars, the Oslo group, therefore asked the question whether more comprehensive obligations that bind states and enterprises could be deduced from other sources of law. The attempts to answer these questions have culminated in the Oslo Principles on Global Climate Change Obligations. The basic methodology that was followed in drafting the Oslo Principles is described. The Oslo group concluded that several concrete obligations to mitigate climate change could be stated by reference to international and domestic law. Particular attention is given in this contribution to tort law as a basis for mitigation obligations in the Oslo Principles but some attention is also given to other areas of law. The central pillar of the Oslo Principles is the primary mitigation obligation, which according to the Principles, is imposed on states. The ambit and nature of this obligation are described. Finally, it is acknowledged that the Oslo Principles only describe rudimentary obligations on enterprises and that it is both difficult and necessary to set out mitigation obligations that can be imposed on enterprises. The contribution finally proposes that the ideas behind the Oslo Principles and United Nations Guiding Principles on Business and Human Rights can be utilised in devising basic mitigation obligations for enterprises.