bluuebunny/crossref_metadata_2025 huggingface dataset:
LncRNAs Landscape in the patients of primary gout by microarray analysis
Authors: Qing Yu-Feng , Zheng Jian-Xiong , Tang Yi-Ping , Dai Fei , Dong Zeng-Rong , Zhang Quan-Bo
Published: February 2021

To determine the expression profile and clinical significance of long non-coding RNAs (lncRNAs) in peripheral blood mononuclear cells (PBMCs) of patients with primary gout and healthy control subjects. Human lncRNA microarrays were used to identify the differentially expressed lncRNAs and mRNAs in primary gout patients (n = 6) and healthy control subjects (n = 6). Bioinformatics analyses were performed to predict the roles of differently expressed lncRNAs and mRNAs. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the expression levels of 8 lnRNAs in 64 primary gout patients and 32 healthy control subjects. Spearman’s correlation was used to analyze the correlation between these eight lncRNAs and the laboratory values of gout patients. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of the lncRNAs identified in gout. The microarray analysis identified 1479 differentially expressed lncRNAs (879 more highly expressed and 600 more lowly expressed), 862 differentially expressed mRNAs (390 more highly expressed and 472 more lowly expressed) in primary gout (fold change > 2, P < 0.05), respectively. The bioinformatic analysis indicated that the differentially expressed lncRNAs regulated the abnormally expressed mRNAs, which were involved in the pathogenesis of gout through several different pathways. The expression levels of TCONS_00004393 and ENST00000566457 were significantly increased in the acute gout flare group than those in the intercritical gout group or healthy subjects (P<0.01). Moreover, inflammation indicators were positive correlated with TCONS_00004393 and ENST00000566457 expression levels. The areas under the ROC curve of ENST00000566457 and NR-026756 were 0.868 and 0.948, respectively. Our results provide novel insight into the mechanisms of primary gout, and reveal that TCONS_00004393 and ENST00000566457 might be as candidate targets for the treatment of gout flare; ENST00000566457 and NR-026756 could effectively discriminate between the gout and the healthy control groups.
Classification aware neural topic model for COVID-19 disinformation categorisation
Authors: Song Xingyi , Petrak Johann , Jiang Ye , Singh Iknoor , Maynard Diana , Bontcheva Kalina
Published: February 2021

The explosion of disinformation accompanying the COVID-19 pandemic has overloaded fact-checkers and media worldwide, and brought a new major challenge to government responses worldwide. Not only is disinformation creating confusion about medical science amongst citizens, but it is also amplifying distrust in policy makers and governments. To help tackle this, we developed computational methods to categorise COVID-19 disinformation. The COVID-19 disinformation categories could be used for a) focusing fact-checking efforts on the most damaging kinds of COVID-19 disinformation; b) guiding policy makers who are trying to deliver effective public health messages and counter effectively COVID-19 disinformation. This paper presents: 1) a corpus containing what is currently the largest available set of manually annotated COVID-19 disinformation categories; 2) a classification-aware neural topic model (CANTM) designed for COVID-19 disinformation category classification and topic discovery; 3) an extensive analysis of COVID-19 disinformation categories with respect to time, volume, false type, media type and origin source.
Dynamic graph embedding for outlier detection on multiple meteorological time series
Authors: Li Gen , Jung Jason J.
Published: February 2021

Existing dynamic graph embedding-based outlier detection methods mainly focus on the evolution of graphs and ignore the similarities among them. To overcome this limitation for the effective detection of abnormal climatic events from meteorological time series, we proposed a dynamic graph embedding model based on graph proximity, called DynGPE. Climatic events are represented as a graph where each vertex indicates meteorological data and each edge indicates a spurious relationship between two meteorological time series that are not causally related. The graph proximity is described as the distance between two graphs. DynGPE can cluster similar climatic events in the embedding space. Abnormal climatic events are distant from most of the other events and can be detected using outlier detection methods. We conducted experiments by applying three outlier detection methods (i.e., isolation forest, local outlier factor, and box plot) to real meteorological data. The results showed that DynGPE achieves better results than the baseline by 44.3% on average in terms of the F-measure. Isolation forest provides the best performance and stability. It achieved higher results than the local outlier factor and box plot methods, namely, by 15.4% and 78.9% on average, respectively.
Risk factors and visual outcome of Non-Arteritic Ischemic Optic Neuropathy (NAION): Experience of a tertiary center in Kuwait
Authors: Behbehani Raed , Ali Abdullah , Al-Moosa Ashref
Published: February 2021

Background

Non-arteritic ischemic optic neuropathy (NAION) is the most common acute optic neuropathy over the age of 50 years. NAION is commonly associated with systemic vascular risk factors (diabetes, hypertension, hyperlipidemia) and small cup-to-disc-ratio. We have assessed the prevalence risk factors of NAION and the visual outcome in patients referred to a tertiary ophthalmology center in Kuwait.

Materials and methods

A retrospective review of new cases of NAION presenting within 2 weeks of onset were included and baseline clinical and demographics characteristic were determined. The prevalence of risk factors and the visual outcome (change in logMAR visual acuity, mean deviation of visual field) was compared between young NAION patients (below 50 years of age) and older NAION patients (over 50 years of age). The odds ratio of a final favorable visual outcome (visual acuity 20/40 or better) by age category was determined.

Results

Seventy-eight eyes of 78 patients with recent onset NAION were included in the study. The most prevalent risk factors for NAION in our subjects were diabetes (64.1%), small cup-to-disc ratio (61.5%), hyperlipidemia (51.3%) and hypertension (38.5%). Young NAION patients had better final logMAR visual acuity (0.55 +- 0.57) then older NAION patients (0.9 +- 0.73), (p = 0.03). Furthermore, young NAION patients were 2.8 times more likely to have a final visual acuity of 20/40 or better than older NAION patients, odds ratio (OR), 2.87; 95% confidence interval (CI), 1.12–7.40, Chi-square p-value = 0.03).

Conclusion

There is a high prevalence of systemic vascular risk factors and small cup-to-disc ratio in NAION patients referred to our center across different age groups (below and above 50 years). Patients below the age of 50 years with NAION are more likely to have a final visual acuity of 20/40 or better than NAION patients above the age of 50 years.
The impact of different weed management strategies on weed flora of wheat-based cropping systems
Authors: Shahzad Muhammad , Jabran Khawar , Hussain Mubshar , Raza Muhammad Aown Sammar , Wijaya Leonard , El-Sheikh Mohamed A. , Alyemeni Mohammed Nasser
Published: February 2021

The world population will rise in future, which would demand more wheat production to fulfil dietary needs of wheat-dependent population of the world. Food security in wheat-dependent regions will greatly rely on wheat productivity. Weed infestation is a major constraint reducing wheat productivity globally. Nonetheless, cropping systems and weed management strategies strongly influence weed infestation in modern agriculture. Herbicides are the key weed management tool in conventional agriculture. However, frequent use of herbicides have resulted in the evolution of herbicide-resistance weeds, which made weed management a challenging task. Sustainable and eco-friendly weed management strategies shift weed-crop competition in the favour of crop plants. Limited studies have evaluated the interactive effect of cropping systems and weed management strategies on weed flora of wheat-based cropping systems (WBCSs). This two-year study evaluated the impact of different weed management strategies (WMSs) on weed flora of WBCSs, i.e., fallow-wheat (FW), rice-wheat (RW), cotton-wheat (CW), mungbean-wheat (MW) and sorghum-wheat (SW). The WMSs included in the study were, false seedbed, allelopathic water extracts and herbicide application, while weed-free and weedy-check were maintained as control treatments. Data relating to diversity and density of individual and total broadleaved and narrow-leaved weeds were recorded. The WBCSs, WMSs and their interaction significantly altered diversity and density of individual, total, broadleaved and narrow-leaved weeds. Weed-free and weedy-check treatments recorded the lowest and the highest values of diversity and density of individual, total, broadleaved and narrow-leaved weeds. Herbicide application effectively reduced density and diversity of weeds. Allelopathic water extracts and false seedbed proved less effective than herbicides. On the other hand, SW cropping system not only reduced weed density but also limited the weed flora. It is concluded that false seedbed and SW cropping system can be efficiently used to manage weeds in WBCSs. However, long-term studies are needed to infer the impact of SW cropping system and false seedbed on soil properties, soil microbes and productivity of wheat crop.
Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
Authors: Terceño Mikel , Remollo Sebastian , Silva Yolanda , Bashir Saima , Werner Mariano , Vera-Monge Víctor A. , Serena Joaquín , Castaño Carlos
Published: February 2021

Background

Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture. We aim to determine the effect of this drugs on the risk of rupture of IA.

Patients and methods

We performed a retrospective cohort study from a prospective database of patients with IA treated in our institution between January 2013 and December 2018. Demographics, previous oral treatments, presence of multiple aneurysms, size of aneurysm, lobulation, location and morphology of the aneurysms were recorded. Patients were dichotomized as ruptured and unruptured IA.

Results

A total of 408 IA were treated, of which 283 (68.6%) were in women. The median age was 53, 194 (47.5%) were ruptured IA. 38 patients (9.3%) were receiving ASA and 84 (20.6%) were receiving statins at the moment of the IA diagnosis. In the multivariable regression analysis, ASA plus statin use and multiple aneurysms were independently associated with unruptured IA (OR 5.01, 95% CI, 1.37–18.33, P = 0.015 and OR 2.72, 95% CI 1.68–4.27, P<0.001, respectively). Whereas, lobulated wall aneurysm and PComA/AComA location were inversely and independently associated with unruptured IA condition (OR 0.34, 95% CI 0.21–0.55, P<0.001 and OR 0.37, 95% CI 0.23–0.60, P<0.001, respectively). However, ASA and statins in monotherapy were not independently associated with unruptured IA condition.

Conclusions

In our study population ASA plus statins treatment is independently associated with unruptured IA. Larger and prospective studies are required to explore this potential protective effect against IA rupture.
An optimized workflow for CRISPR-Cas9 deletion of surface and intracellular factors in primary human T lymphocytes
Authors: Leoni Cristina , Bianchi Niccolò , Vincenzetti Lucia , Monticelli Silvia
Published: February 2021

The appropriate regulation of T lymphocyte functions is key to achieve protective immune responses, while at the same time limiting the risks of tissue damage and chronic inflammation. Deciphering the mechanisms underpinning T cell responses in humans may therefore be beneficial for a range of infectious and chronic diseases. Recently, the development of methods based on CRISPR-Cas9 gene-editing has greatly expanded the available tool-box for the mechanistic studies of primary human T cell responses. While the deletion of a surface protein has become a relatively straightforward task, as long as an antibody for detection is available, the identification and selection of cells lacking an intracellular protein, a non-coding RNA or a protein for which no antibody is available, remain more problematic. Here, we discuss the options currently available to scientists interested in performing gene-editing in primary human T lymphocytes and we describe the optimization of a workflow for the screening and analysis of lymphocytes following gene-editing with CRISPR-Cas9 based on T cell cloning and T7 endonuclease I cleavage assay.
DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity
Authors: Boyle William K. , Richards Crystal L. , Dulebohn Daniel P. , Zalud Amanda K. , Shaw Jeff A. , Lovas Sándor , Gherardini Frank C. , Bourret Travis J.
Published: February 2021

Throughout its enzootic cycle, the Lyme disease spirochete Borreliella (Borrelia) burgdorferi, senses and responds to changes in its environment using a small repertoire of transcription factors that coordinate the expression of genes required for infection of Ixodes ticks and various mammalian hosts. Among these transcription factors, the DnaK suppressor protein (DksA) plays a pivotal role in regulating gene expression in B. burgdorferi during periods of nutrient limitation and is required for mammalian infectivity. In many pathogenic bacteria, the gene regulatory activity of DksA, along with the alarmone guanosine penta- and tetra-phosphate ((p)ppGpp), coordinate the stringent response to various environmental stresses, including nutrient limitation. In this study, we sought to characterize the role of DksA in regulating the transcriptional activity of RNA polymerase and its role in the regulation of RpoS-dependent gene expression required for B. burgdorferi infectivity. Using in vitro transcription assays, we observed recombinant DksA inhibits RpoD-dependent transcription by B. burgdorferi RNA polymerase independent of ppGpp. Additionally, we determined the pH-inducible expression of RpoS-dependent genes relies on DksA, but this relationship is independent of (p)ppGpp produced by Relbbu. Subsequent transcriptomic and western blot assays indicate DksA regulates the expression of BBD18, a protein previously implicated in the post-transcriptional regulation of RpoS. Moreover, we observed DksA was required for infection of mice following intraperitoneal inoculation or for transmission of B. burgdorferi by Ixodes scapularis nymphs. Together, these data suggest DksA plays a central role in coordinating transcriptional responses in B. burgdorferi required for infectivity through DksA’s interactions with RNA polymerase and post-transcriptional control of RpoS.
Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses
Authors: Le Sage Valerie , Jones Jennifer E. , Kormuth Karen A. , Fitzsimmons William J. , Nturibi Eric , Padovani Gabriella H. , Arevalo Claudia P. , French Andrea J. , Avery Annika J. , Manivanh Richard , McGrady Elizabeth E. , Bhagwat Amar R. , Lauring Adam S. , Hensley Scott E. , Lakdawala Seema S.
Published: February 2021

Human-to-human transmission of influenza viruses is a serious public health threat, yet the precise role of immunity from previous infections on the susceptibility to airborne infection is still unknown. Using the ferret model, we examined the roles of exposure duration and heterosubtypic immunity on influenza transmission. We demonstrate that a 48 hour exposure is sufficient for efficient transmission of H1N1 and H3N2 viruses. To test pre-existing immunity, a gap of 8–12 weeks between primary and secondary infections was imposed to reduce innate responses and ensure robust infection of donor animals with heterosubtypic viruses. We found that pre-existing H3N2 immunity did not significantly block transmission of the 2009 H1N1pandemic (H1N1pdm09) virus to immune animals. Surprisingly, airborne transmission of seasonal H3N2 influenza strains was abrogated in recipient animals with H1N1pdm09 pre-existing immunity. This protection from natural infection with H3N2 virus was independent of neutralizing antibodies. Pre-existing immunity with influenza B virus did not block H3N2 virus transmission, indicating that the protection was likely driven by the adaptive immune response. We demonstrate that pre-existing immunity can impact susceptibility to heterologous influenza virus strains, and implicate a novel correlate of protection that can limit the spread of respiratory pathogens through the air.
The theatre of cruelty and the limits of representation: Sade/Salò
Authors: Romanska Magda
Published: February 2021

When first released in 1975, Salò or the 120 Days of Sodom, directed by the already-notorious Italian director Pier Paolo Pasolini, aroused instant controversy. As a framework for its plot, Salò took the infamous 500-page novel by the Marquis de Sade, 120 Days of Sodom. In de Sade’s novel, four libertines, President de Curval, the Duc de Blangis, Durcet and the Bishop of X, sign a contract whose main clause is commitment to breaking as many taboos as they can possibly think of. With sixteen youths, eight girls and eight boys, servants, guards and four procurers and ex-prostitutes, the libertines isolate themselves in a remote chateau to re-enact their every fantasy. Filming Salò, Pasolini’s goal was to remain faithful to Sade’s novel. The characters, events and structure of the story remain the same. The more controversial aspect of the film, however, was Pasolini’s idea of relocating Sade’s novel into the actual historical context of the fascist Republic of Salò. For Pasolini, the gesture of moving Sade to Salò was to draw an actual analogy between the fascism and sadism. For some critics, the parallel between fascism and sadism was unfortunate exactly because it presented fascism, a real and palpable phenomenon, as an abstraction (the way that Sade’s world functions).
Problemas de sumar y restar en los Cuadernos Rubio (España)
Authors: Carrillo Gallego Dolores , Castejón Mochón José Francisco , Olivares Carrillo Pilar
Published: February 2021

Los cuadernos Rubio de aritmética han sido ampliamente utilizados en España para el aprendizaje de las operaciones aritméticas básicas desde su aparición en 1959. En el trabajo se han identificado seis épocas en la edición de estos cuadernos y se estudian los problemas de sumar y restar que proponen; para ello, se utilizan las categorías formuladas por G. Vergnaud para el campo conceptual de las estructuras aditivas. Se analizan cuadernos de problemas de la edición de 1978 (época 2), tanto los problemas verbales como los gráficos, constatando que son de los tres primeros tipos, entre los seis formulados por Vergnaud. Se estudia la evolución de estos cuadernos hasta los que se comercializan actualmente: hay continuidad en los problemas propuestos y los cambios, aparte de los producidos para adaptarlos al cambio de moneda al euro, afectan al diseño, no al contenido.
Llegada de las ideas de la didáctica de la matemática francesa a los documentos oficiales de la municipalidad de Buenos Aires
Authors: Deriard Alejandra
Published: February 2021

Ante la inexistencia de referencias historiográficas acerca de la llegada de la Didáctica de la Matemática francesa a Buenos Aires, se realiza una búsqueda de los actores pertenecientes a ese espacio temporal y se los contrasta con fuentes documentales. Los resultados indican que esta teoría didáctica ingresa a Buenos Aires mediante un proceso de triangulación Francia, México, Buenos Aires, a fines de la década de 1980, constituyéndose en grupos de investigación. La puesta en marcha de situaciones didácticas, del estilo de las utilizadas por Brousseau (Brousseau, 1986) durante los procesos investigativos, fueron consecuencia del armado de equipos de investigación, cuyo efecto fue la escritura de documentos oficiales y del Diseño Curricular de la Ciudad de Buenos Aires. Se utilizan para el análisis metodologías correspondientes a la Historia Presente, siguiendo las recomendaciones metodológicas de Arostegui (2004) y de Valente (2007) con respecto a la Historia de la Enseñanza de la Matemática.
A matemática do ensino e o ensino de matemática: as frações nos primeiros anos escolares, segunda metade do século XIX
Authors: Rodrigues Valente Wagner
Published: February 2021

Este texto divulga resultados de pesquisas que vêm sendo desenvolvidas no âmbito de um grupo de investigadores em torno de projetos coletivos de trabalho. Tais projetos têm por interesse analisar historicamente as mudanças no saber profissional do professor que ensina matemática nos primeiros anos escolares. Em específico, para este artigo, privilegiou-se o estudo pontual sobre as frações. Utiliza-se como aparato teórico-metodológico os estudos culturais, em particular, mobiliza-se o conceito de cultura escolar, considerando a escola como produtora de saberes no seio dessa cultura. A partir dessa referência explicitam-se as diferenças entre «matemática do ensino» e «ensino de matemática». A pergunta norteadora que conduz o artigo pode ser enunciada do seguinte modo: Como caracterizar a matemática do ensino de frações na segunda metade do século xix? Os resultados mostram a organização de uma matemática do ensino de frações que se altera em razão das necessidades de escolarização do sistema métrico decimal.
Una encuesta paralizada en el tiempo: el cuaderno de preparación de lecciones
Authors: Ortiz De Santos Rosa
Published: February 2021

En 1932 la revista Escuelas de España publicó las respuestas de una veintena de maestros a una encuesta sobre el cuaderno de preparación de lecciones. Informaba de que, más adelante, compartirían el análisis y las conclusiones del estudio. La desaparición temporal de la revista provocó que estos datos no llegasen a ser objeto de análisis. En esta propuesta, siendo conocedores de la evolución que vivieron los cuadernos de preparación, damos continuidad a la investigación. Los resultados evidencian el valor que los docentes encuestados otorgaban a los cuadernos como un recurso que favorecía la autonomía y el empoderamiento del profesorado. Al mismo tiempo, de manera casi premonitoria, temían que llegasen a utilizarse como un instrumento de control de la actividad docente.
O conhecimento do professor em tempos de mudança curricular. O caso da telescola portuguesa (1965-1967)
Authors: Almeida Mária Cristina , Matos José Manuel
Published: February 2021

Este artigo procura conhecer os modos como a comunicação de ideias matemáticas foi levada a cabo na implementação da Telescola em Portugal durante os anos de 1965/66 e 1966/67 e que, para além do uso educativo da televisão, incorpora também a inovação curricular da Matemática Moderna. Este artigo investiga os saberes matemáticos expressos em documentação associada aos dois anos letivos iniciais da Telescola em Portugal (1965/66 e 1966/67). Procuraremos identificar não só o conhecimento comum do conteúdo matemático, mas especialmente o seu conhecimento especializado. Procuraremos igualmente determinar como esses  conhecimentos evoluíram em consequência da introdução da matemática moderna.
A munkával kapcsolatos értékek és attitűdök változása Közép-Kelet Európában a XXI. század első évtizedében (Changing values and attitudes regarding labour in Central- Eastern Europe in the first decade of 21st century)
Authors: Borgulya Istvánné Vető Ágnes
Published: February 2021

A szerző tanulmányában a 2000 és 2010 közötti gazdasági és társadalmi változásokat és a munkával kapcsolatos értékek és attitűdök alakulását állítja időbeli párhuzamba, és azokra a kérdésekre keresi a választ, hogy milyen prioritások jellemzik 2010-ben a munka egyes aspektusaihoz való viszonyulást Közép-Kelet- Európa uniós tagállamaiban, és közöttük kiemelten Magyarországon? Vajon változtak-e ezek a jellemzők az elmúlt tíz év során, s ha igen, milyen irányú az elmozdulás. Azonos tendenciájúak-e a változások a vizsgált országokban? Megállapíthatók-e jellegzetes különbségek három kiválasztott, magas életszínvonalú, régebbi uniós (EU-15) tagországhoz viszonyítva? Elemzése jelentős mértékben támaszkodik az EVSfelmérés 2010-ben közzétett adataira, melynek alapját a 2008 és 2009 során lefolytatott adatgyűjtés képezi. Tanulmányában azokra a közép-kelet-európai országokra összpontosít, amelyek az elmúlt évtized során az unió tagjai lettek, és a 2000-es felmérésben is részt vettek már. _____ The author sets into parallelism economic and social changes and the development of values and attitudes regarding labour between 2000 and 2010, and looks for answers to questions what priorities characterize in 2010 the attitude to some aspects of labour in EU member countries of CEE, and especially in Hungary. Have these features changed in the last decade and in positive case, what is the direction of the shift? Are changes of similar tendency in countries under consideration? Can considerable differences be stated as compared to three selected, earlier EU 15 member countries with high living standard? The analysis largely relies on data of EVS survey, published in 2010 whose basis is the data collection carried out in 2008-2009. The essay focuses on Central Eastern European countries which have become members of the Union during the last decade and took part already in the survey of 2000.
A fogyasztói lojalitás előzményei a magyar mobiltelefonos szolgáltatási piacon – A bizalom szerepe (Antecedents of the consumer loyalty in the Hungarian telecommunication market – the role of trust)
Authors: Simay Attila Endre
Published: February 2021

A fogyasztói lojalitás kritikus versenyelőnynek számít a szolgáltatóknak a telekommunikációs szektorban, ahol a piac növekedésének lassulásával és az erősödő piaci verseny folytán a vállalatoknak inkább a fogyasztók megtartására kell fókuszálniuk. Egyre fontosabbá vált és válik a piaci részesedés, illetve a már meglévő ügyfelek megtartása, mivel az új ügyfelek megszerzésének költsége és nehézsége is megnőtt. Az ügyfelek megtartásához ki kell vívni a hosszú távú kapcsolat fenntartását, vagyis a fogyasztók lojalitását. A korábbi marketing-irodalomban a fogyasztók elégedettségének szerepe a lojalitás kialakításában vitathatatlan, azonban felmerül a kérdés, hogy mennyire közvetlen ez a hatás. Így érdemes megvizsgálni, mint közvetítő változónak az elégedettség és lojalitás között, a fogyasztói bizalom szerepét is a fogyasztói lojalitás formálódásában. A szerző empirikus kutatásának eredményei azt támasztják alá, hogy a fogyasztói elégedettség hatása a fogyasztói lojalitásra nem feltétlenül közvetlen, hanem a fogyasztói bizalom játszik közvetítő szerepet, és a bizalom a fogyasztói lojalitás erősebb indikátorának bizonyult, mint egyedül az elégedettség. / === / The consumer loyalty is a crucial competitive advantage in the telecommunication sector, which has a decreasing growth rate and increasing market competition, so the companies should focus on the consumer retention. The market share and the retention of present consumers become more and more important, because both the cost and the difficulty of the acquisition of new consumers are increased. The previous marketing literature states that the role of satisfaction in loyalty is evident, but the effect is not necessary a direct one. Worth to examine the role of consumer trust in loyalty creation, where trust is a mediator variable between satisfaction and loyalty. The author’s empirical results suggest the direct effect of satisfaction on loyalty is not necessary direct, but indirect, where the consumer trust is the link. The effect of trust on loyalty is higher than the satisfaction alone.
Vállalati stratégiák, konfigurációk Magyarországon 1992 és 2010 között – 1. rész (Corporate strategies, configurations in Hungary between 1992 and 2010)
Authors: Szabó Zsolt Roland
Published: February 2021

A vállalatok közvetlen versenytársaikkal összevetett eredményei alapján képzett teljesítményértékelési dimenziók, és az azok szerint képzett vállalati stratégiai archetípusok, konfigurációk azonosítása, leírása áll az empirikus kutatás fókuszában. Ezek során a szerző azonosítja a vállalati stratégiák archetípusait, felhasználva a konfigurációs iskola módszertanát. A kutatás az 1992 és 2010 között felvett magyarországi adatsorok alkalmazásával, több mint 1200 felsővezetői vélemény alapján készült. A válaszok alapján a vállalatok teljesítményét hét, egymástól független dimenzió mentén különíti el, melyek alapján különböző vállalatistratégia-típusok azonosíthatók. A kiemelkedő vállalati teljesítmény elérése érdekében a szerző konkrét ajánlásokat fogalmaz meg cikkében ______________ The identification and description of the strategic archetypes (configurations) are the focus of the empirical research. The author identifies and describes the archetypes of the adaptation strategies by using the methodology of the configuration school. The dataset of the research consists of more than 1200 CEO’s responses from Hungary between 1992 to 2010. Based on the responses, corporate performance has 7 independent dimensions, and they are suitable to identify and descripe different strategic archetypes. Based on the results, the article has practical advices how to deliver superior corporate performance.
Keresleti-kínálati diszharmónia a szervezeti kultúra tükrében (Demand–supply disharmony in the organizational culture)
Authors: Balogh Ágnes , Bogdány Eszter , Cserháti Gabriella , Csizmadia Tibor , Polák-Weldon Réka
Published: February 2021

A szerzők kutatásának célja ráirányítani a figyelmet arra a tényre, hogy a tényleges és potenciális munkavállalók szervezeti kultúrára vonatkozó vágyai és a valóság között jelentős eltérés tapasztalható. Napjaink pénzpiaci és reálgazdasági válságának hatásaként még fokozottabban jelentkezik az igény a változásra, változtatásra nemcsak a szervezetek, de az egyén szintjén is. Ahhoz azonban, hogy a változtatás lehetséges útjai, módjai közül megalapozottan lehessen választani, nemcsak a kívánatos cél kitűzésére, de a kiinduló állapot minél precízebb meghatározására is szükség van. Jelen cikkükben a szerzők egyrészt azokról az eredményekről számolnak be, amelyek az egyetemi hallgatók „vágyott” munkahelyének szervezeti kultúráját, és ennek kapcsolatát a tényleges piaci kínálattal mutatják be. Másrészt egy közszolgáltató cég példáján a munkavállalók szervezeti kultúrára vonatkozó vágyai és a valóság kapcsolatával foglalkoznak. _____ The aim of the authors is to review and examine the gap between the aspirations and reality regarding organizational culture of those already employed and those seeking employment. These days the financial and real economic crisis generated an increased demand for change on the part of organizations as well as individuals. However, in order to map the possibilities for change and formulate a well-founded decision on which alternative to adopt it is essential to define the starting point and to set clear aims. Present article outlines the research results of the aspirations of university students regarding the organizational culture of their possible future workplaces and how they can be related to the reality of labor market supply. Furthermore, by providing the case of a public utility company, the aspirations of employees regarding organizational culture and the way it relates to reality is also presented.
A piaci likviditás hatása a vállalatokra (The effect of market liquidity for companies)
Authors: Michaletzky Márton
Published: February 2021

A 2007-ben kezdődő pénzügyi eredetű világgazdasági válság nyilvánvalóvá tette a kapcsolatot a likviditás két fajtája, a finanszírozási és a piaci likviditás között. A cikk megismertet a piaci likviditással kapcsolatos olyan alapvető fogalmakkal, mint order flow, ajánlati könyv, piaci struktúrák, bemutatja a piaci likviditás dimenzióit, a likviditás néhány mutatószámát és a piaci likviditás stilizált tényeit. A banki likviditáskezelés rövid összefoglalásán túl bevezetést nyújt a portfóliók likviditáskockázat melletti értékelésébe, végezetül összefoglalja, hogy az alapvetően finanszírozási likviditási kockázatnak kitett nem pénzügyi vállalatok hogyan vehetik figyelembe döntéseik meghozatalakor a piaci likviditást. _____________________ The global financial crisis starting in 2007 has showed that the connection between market liquidity and funding liquidity is apparent. This paper introduces the basic notions regarding market liquidity such as order flow, order book, and market structures. The article also presents the various dimensions of market liquidity, several measures of liquidity and the stylized facts of market liquidity. Besides a short description of liquidity management of banks it briefly introduces portfolio valuation in the presence of liquidity risk. Finally, the paper gives insight to non-financial companies, fundamentally exposed to funding liquidity risk, on how to consider market liquidity in their decisions.
Influence of cardiovascular risk factors on pre-mild cognitive decline at middle and old age
Authors: Koberskaya N. N. , Yakhno N. N. , Gridin V. N. , Smirnov D. S.
Published: February 2021

Much attention is currently paid to non-dementia cognitive impairment, such as mild cognitive impairment and pre-mild cognitive decline (PMCD), since their timely detection and optimal correction increase the possibility of preventing dementia.

Objective: to analyze the neuropsychological characteristics of patients with PMCD depending on the presence or absence of cardiovascular risk factors (CVRFs): hypertension, cardiac disorders (ischemic heart disease, intracardiac conduction disturbance), and prior stroke and myocardial infarction, as well as diabetes mellitus.

Patients and methods. Examinations were made in 182 patients (132 women, 50 men; mean age, 59.32±5.41 years) with PMCD and CVFRs, 101 patients (77 women, 24 men; mean age, 59.45±7.04 years) with PMCD without CVRFs, and 77 control persons (55 women, 22 men; mean age, 60.55±5.65 years). All underwent general clinical, neurological, and clinical psychological studies using rating scales and tests.

Results and discussion. The patients with PMCD and CVRFs had lower scores on all neuropsychological tests than the control group and on most tests than the patients with PMCD without CVRFs. In addition to some deterioration in memory indicators, the patients with CVRFs performed worse executive function tests. Cluster analysis showed that in the patients with PMCD, the severity of cognitive decline was considerably affected by hypertension, cardiac disorders, and diabetes mellitus; among them, hypertension was of the most significance.

Conclusion. The association of cognitive decline with the burden of CVRFs indicates their important role in the deterioration of cognitive functions in PMCD.
Systematic analysis of molecular biological mechanisms for supporting connective tissue metabolism with chondroitin sulfate
Authors: Torshin I. Yu. , Gromova O. A. , Nechaeva G. I. , Reier I. A. , Zagorodniy N. V.
Published: February 2021

Objective: to analyze the roles of undifferentiated connective tissue dysplasia (UCTD) in the development of cartilage and ligamentous apparatus diseases.

Material and methods. This paper presents the results of analyzing the literature on fundamental and clinical studies of relationships between chondroitin sulfate (CS) and connective tissue (CT) disease. A total of 922 publications on the relationship between CT dysplasia and CS and 2249 publications on CS receptor molecules were analyzed. These arrays of publications were analyzed using topological and metric approaches to data analysis.

Results and discussion. The genetic predisposition to UCTD is substantially aggravated by inadequate nutrition that leads to deficiency of certain micronutrients that support CT reconstructive processes. The paper presents the results of a systematic analysis of prospects for the use of drugs based on standardized CS substances in patients with UCTD. CS is a material for CT reconstruction. CS increases the activity of growth factors and reduces CT inflammatory destruction (inhibition of the secretion of histamine, pro-inflammatory chemokines, Toll-like receptors, and the NF-κB cascade through exposure to the CD44 receptor).

Conclusion. The pharmacological effects of CS indicate the importance of using standardized CS forms in the treatment of patients with UCTD.
Biophysical Characterization of Thin Films of Zinc Oxide Prepared by Sol-Gel
Authors: Almohana Abothur , Jawad Radea Hateem
Published: February 2021

In this research, ZnO nano-powder was used, and the work was in two biological and physical parts. Where the work of the first part was to examine the effect of ZnO powder on Staphylococcus aureus, and the result of inhibition was 100%. As for the second part, the preparation of a thin film by the Sol-Gel method, where thin films were deposited on glass, the structural properties and topography of the surface were studied. The prevailing trend (101). Also, the results of the atomic force microscopy (AFM) tests showed that the resulting granular size of the prepared and annealed films with a temperature (400 ° C) was less than 100 nm, wherein an anti-bacterial nanoscale S. aureus was made.
Johann Schreck Terrentius, SJ - Index
Authors: Golvers Noël
Published: February 2021

Concordance Terrentius: Verhaeren

Index Geographicus

Index Terminologicus

Index Thematicus
Nutrition knowledge and its relation with dietary behaviour in children and adolescents: a systematic review
Authors: Thakur Sunaina , Mathur Pulkit
Published: February 2021

Objectives

This review explored the relationship between knowledge among children and adolescents and their dietary behaviour.

Content

Potentially eligible original research articles were identified through a systematic search in PubMed, SCOPUS, Web of Science and WHO Virtual Health Library from 2000 to 2018. From the initial search, a total of 7,258 research articles were obtained. Duplicate studies were identified and removed. Observational studies on children and adolescents (5–19 years) of any gender, ethnicity and country were included in which the outcome measured was either a scoring of/ association between nutrition knowledge and practices. After screening using the inclusion criteria, 13 studies were selected for this paper.

Summary and Outlook

Four studies reported non-significant association between overall nutrition knowledge and practices. Only two studies found a significant association, out of which one showed a weak association highlighting that nutrition knowledge is not sufficient to result in healthy eating. Other factors which showed significant but weak associations with knowledge/practices included age, gender, nutritional status and lifestyle, peer influence, parents’/guardians’ knowledge, education and occupation level. The causal relationship couldn’t be examined in the present review due to the cross-sectional nature of the studies. Besides imparting knowledge through nutrition education interventions, there is a need for holistic behaviour change strategies including supporting food skills like menu planning, food shopping and cooking to encourage healthy eating habits among children. These interventions should target children from an early age, involving family/parents, teachers and peers to facilitate improvement in the food environment for sustainable change.
Ein praxistheoretischer und funktionaler Blick auf Konzepte für Deutsch als Zweitsprache für den Beruf
Authors: Daase Andrea
Published: February 2021

Der Beitrag greift Überlegungen zum Konzept Sprache als soziale Praxis und seiner didaktischen Umsetzung aus EU-Projekten zum Berufsbezogenen Deutsch als Zweitsprache auf und führt sie mittels praxistheoretischer Ansätze fort. Als ein mit dieser Sicht kompatibles und für didaktische Zwecke produktives Konzept wird die Funktionale Grammatik nach Halliday und Schleppegrell vorgeschlagen. Unter Rückgriff auf aktuelle Konzepte werden Anregungen für die Unterrichtspraxis vorgestellt.
How does Tort Law deal with Historical Injustice?
Authors: Loth Marc
Published: February 2021

How does tort law deal with historical injustice? This question appears of increasing relevance since the global quest for the reparation of historical injustices influences tort law. This contribution seeks to offer an answer to it by addressing three sub-questions: (1) how may reparation be claimed, that is, what kind of reparation claims are possible and what problems do they encounter?; (2) why should these claims be sustained, that is, how do they fit in the traditional legitimation patterns of tort law?; and (3) when are they most likely to be sustained, that is, what conditions will enhance their chances of success? In this article I draw on examples from the slavery reparation suits in the US, post-colonial redress cases in the Netherlands, and sexual abuse cases against clergymen (amongst others). I conclude that only under specific circumstances can tort law offer a remedy for historical injustice. Amongst the variables of successful claims are the period of time that has lapsed, the nature of the parties, the remedies claimed, the moral legitimation, and political considerations. This list is not closed, however, since many more cases are to be expected.
Librarians’ Perceptions of the Challenges for Researchers in Rwanda and the Potential of Open Scholarship
Authors: Cox Andrew , Abbott Pamela
Published: February 2021

Open scholarship is a major reform movement within research. This paper seeks to understand how open scholarship might address the challenges faced by research in Africa, through a study based on a participatory collaborative workshop to create a partnership with librarians in Rwanda. The literature review identifies three broad perspectives on the apparent under-performance of Rwandan research: one locating the issue in the unequal scholarly communications system, a second pointing to a country deficit and a third blaming cognitive injustices. The Rwandan librarians see researchers as challenged through the pressures on them to publish, the costs of research, poor infrastructure, lack of skills and limited access to literature. Collectively these challenges constitute a critical barrier to research. These limits fit largely the country deficit perspective. Open scholarship as conceived in the Global North is only a small part of the answer to the challenges faced by Rwandan scholars. To promote equity, notions of open scholarship need to take into account the conditions under which research is conducted in less privileged contexts such as Rwanda.
Counterpart Theories: The Argument from Concern
Authors: Baber Harriet E.
Published: February 2021

Modal counterpart theory identifies a thing’spossibly being Fwith its having a counterpart that isFat another possible world; temporal counterpart theory, thestage view, according to which people and other ordinary objects are instantaneous stages, identifies a thing’shaving been Forgoing to be F, with its having a counterpart that isFat another time. Both counterpart theories invite what has been called ‘the argument from concern’ (Rosen, G. 1990. “Modal Fictionalism.” Mind 99 (395): 327–54). Why should I be concerned about my counterparts at other possible worlds or other times? I care about how things might have gone forme—not how they go for other people at other possible worlds; I care aboutmyprospects—not the way go for other people at other times. Jiri Benovsky has argued that while modal counterpart theory can be defended against this style of argument, temporal counterpart theory cannot (Benovsky, J. 2015. “Alethic Modalities, Temporal Modalities, and Representation.” Kriterion: Journal of Philosophy 29: 18–34). I argue that temporal counterpart theory, like modal counterpart theory, resists the argument from concern.
New fractional order discrete Grüss type inequality
Authors: Asliyüce Serkan , Güvenilir A. Feza
Published: February 2021

The aim of this study is to establish new discrete Grüss type inequality using fractional order h-sum and h-difference operators that generalize the fractional sum and difference operators.
The crystal structure of 10-(3,5-di(pyridin-4-yl)phenyl)-10H-phenoxazine dihydrate, C28H23N3O3
Authors: Yang Zhuqing , Hou Meng
Published: February 2021

C28H23N3O3, orthorhombic, Pna21 (no. 33), a = 29.0466(11) Å, b = 5.2448(3) Å, c = 14.4825(7) Å, V = 2206.32(19) Å3, Z = 4, R

gt
(F) = 0.0511, wR

ref
(F
2) = 0.1341, T = 100.00(10) K.
Assessment of deficit irrigation efficiency. Case study: Middle Sebou and Innaouene downstream
Authors: Moumen Zineb , Elhassnaoui Ismail , Khaddi Walid , Wahba Mohamed A. S. , Lahrach Abderrahim
Published: February 2021

Future projection shows that the availability of freshwater per capita will decrease to 560 m3/year by 2030 in Morocco. In this realm of adopting efficient irrigation, alternatives become a priority to overcome water shortage. The presented study aims to investigate theoretically the likelihood of improving irrigation efficiency at the plot level of the Middle Sebou and Innaouene downstream perimeter using 75% of the total irrigation water requirement (IWR), based on the successful results obtained by the Moroccan National Institute for Agronomic Research. The methodology consists of the extraction of monthly evaporation data from MODIS16A2 and process it under Google Earth Engine (GEE); data that are used in the second part of the study, which aims to assess the efficiency of deficit irrigation on a plot of 2,500 olive tree, using three main indexes; olive three height (cm), Stomatal conductance (mmol H2O m−2 s−1), and olive tree growth (cm). The results show that 0.75 of full irrigation could save 17% of the total water used, reducing the water irrigation supply by an average of 5 Mm3, with a slight decreasing of the olive production, estimated as 0.5 t/ha. Furthermore, water use efficiency and water productivity have been enhanced under deficit irrigation by respectively 0.25 kg/m3 and 0.54 Dh/m3. In economic terms, the result shows that with deficit irrigation, the decision-maker, or the farmer, could save about 5 million m3 per year, which is a boost to the global economy if the method is transposed and applied to other Moroccan regions and also a support for the new agricultural strategy called Generation Green.
Existenzvernichtung, Unterkapitalisierung, kalte Liquidation
Authors: Schirrmacher Carsten
Published: February 2021

Seit der Trihotel-Entscheidung aus dem Jahr 2007 sieht der BGH im existenzvernichtenden Eingriff eine vorsätzliche sittenwidrige Schädigung der Gesellschafter zum Nachteil ihrer GmbH. Ein Nachteil dieser Konzeption wird zumeist in der Unbestimmtheit des Tatbestands gesehen. Der vorliegende Beitrag soll Leitlinien zur Konkretisierung und Weiterentwicklung des anzulegenden Sittlichkeitsmaßstabs aufzeigen. Er findet seinen Ursprung in den Liquidationsvorschriften. So verstanden bietet die Existenzvernichtungshaftung ein dogmatisches Konzept, das nicht nur stimmig ist, sondern auch auf benachbarte und seit jeher kontrovers diskutierte Fallgruppen der Gesellschafterhaftung Anwendung finden kann, insbesondere auf die materielle Unterkapitalisierung.