bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Egyptian Mothers’ Knowledge and Domestic Management Practices of Fever in Preschool Children in Zagazig City, Sharkia Governorate
Authors: Waly Eman H. , Bakry Huny M.
Published: March 2022

(1) Background: Childhood fever is a frequent reason for health care visits. Parents are worried about fever and its complications and show variation between their knowledge about managing fever and real practice, which are affected by many factors and beliefs. This study aimed to assess knowledge of Egyptian mothers about fever of preschool children and its domestic management and the relation between them and to identify sociodemographic factors affecting mothers’ knowledge and practice. (2) Methods: a cross-sectional study was conducted at the pediatric outpatient clinic at Zagazig University Hospitals among 297 mothers with preschool children. A structured questionnaire consisting of three parts assessed the sociodemographic characteristics, mothers’ knowledge about childhood fever, and its management practices. (3) Results: 37.7% of mothers had good knowledge about childhood fever, and 23.9% showed good management practices. Young mothers, less number of children, high education, sufficient income, and good knowledge were the significant predictors of domestic management practices towards childhood fever. (4) Conclusions: The Egyptian mothers showed insufficient levels of knowledge and domestic management practices towards preschool childhood fever. Health education interventions should be targeted to mothers to improve their knowledge and practice.
Citizen Science Contributions to the Conservation of Sea Turtles Facing Port City and Land Use Stressors in the Mexican Central Pacific
Authors: Cervantes-Rosas Omar , Hernández-López Julieta , Verduzco-Zapata Gerardo Manuel , Pérez-Morales Alfredo , García-Villalvazo Patricia , Quijano-Scheggia Sonia Isabel , Olivos-Ortiz Aramis
Published: March 2022

The unplanned development of a port city generates urban growth in its coastal zone that stresses the local biotic and abiotic resources, affecting the nesting beach areas of sea turtles. This work evaluated the impact of social collaboration on sea turtle conservation in response to coastal rigidization. Over the past twenty years, the Manzanillo Port (Colima), located in the Mexican Central Pacific, underwent vigorous development and urbanization. This growth has produced stressors including increasing levels of marine noise pollution due to the transit of merchant ships, the decrease in 4.3 ha in beach areas, and increased light pollution, which likely reduced the number of turtles that reached the nesting stage. Despite the above, the number of turtle nests has increased thanks to social collaboration through protection actions, education programs, and the participation of volunteers along with public and private organizations supported by the media and social networks. These actions are part of citizen science and contribute to the balance between urban development and the protection of sea turtles, reducing environmental vulnerability in the coastal zone. This success story can be reproduced in coastal cities for other wildlife species to achieve a social-ecological benefit through advocacy projects that involve the empowerment of local inhabitants and the appropriation of their landscapes and natural elements. These projects will contribute to alleviating the effects of coastal rigidization in the face of future challenges that will require solutions to different environmental aspects of imminent climate change.
Preparation and Study on Fretting Tribological Behavior of Composite Lubrication Structure on the Titanium Alloy Surface
Authors: Ma Zhen , Song Junjie , Fan Hengzhong , Hu Tianchang , Hu Litian
Published: March 2022

As an excellent light metal material, titanium alloy has an important application in high technology equipment. In this study, the composite lubrication structure was prepared on the titanium alloy surface by combining the surface texture, thermal oxidation layer, and polytetrafluoroethylene (PTFE)-based lubricating coating. The effect of texture parameters and thermal oxidation layer on the fretting wear behavior of the composite lubrication structure was evaluated under a load of 50 N. The results showed that the PTFE-based lubricating coating on the textured surface showed excellent friction-reduction and anti-wear effect compared with the coating on the single smooth surface and thermal oxidation surface. The introduction of a thermal oxidation layer on the textured surface further improved the fretting wear life of lubrication coating. The friction coefficient and wear rate can be as low as 0.242 and 2.3 × 10−5 mm3·N−1m−1, respectively, under dry fretting contact conditions. Compared with the untextured surface, the longevity of the composite lubrication structure is extended by more than 90%.
GWAS for Stripe Rust Resistance in Wild Emmer Wheat (Triticum dicoccoides) Population: Obstacles and Solutions
Authors: Tene May , Adhikari Elina , Cobo Nicolas , Jordan Katherine W. , Matny Oadi , del Blanco Isabel Alicia , Roter Jonathan , Ezrati Smadar , Govta Liubov , Manisterski Jacob , Yehuda Pnina Ben , Chen Xianming , Steffenson Brian , Akhunov Eduard , Sela Hanan
Published: March 2022

Stripe rust is a devastating disease in wheat that causes substantial yield loss around the world. The most effective strategy for mitigating yield loss is to develop resistant cultivars. The wild relatives of wheat are good sources of resistance to fungal pathogens. Here, we used a genome-wide association study (GWAS) to identify loci associated with stripe rust (causal agent: Puccinia striiformis f. sp. tritici) resistance in wild emmer (Triticum dicoccoides) at the seedling stage, in the greenhouse, and at the adult plant stage, in the field. We found that the two major loci contributing to resistance in our wild emmer panel were the previously cloned seedling-stage resistance gene, Yr15, and the adult-plant-stage resistance gene, Yr36. Nevertheless, we detected 12 additional minor QTLs that additionally contribute to adult plant resistance and mapped a locus on chromosome 3AS that tentatively harbors a novel seedling resistance gene. The genotype and phenotype data generated for the wild emmer panel, together with the detected SNPs associated with resistance to stripe rust, provide a valuable resource for disease-resistance breeding in durum and bread wheat.
Theoretical Model for a Novel Electronic State in a Dirac Electron System Close to Merging: An Imaginary Element between Sulphur and Selenium
Authors: Naito Toshio , Suzumura Yoshikazu
Published: March 2022

Topological materials with Dirac electron systems have been extensively studied. Organic crystalline materials form a unique group of such compounds with well-defined crystal structures. While most organic compounds require high pressures to exhibit Dirac-cone-type band structures, the title compound, α-STF2I3, has garnered increasing interest due to its Dirac-cone-type band structure under ambient pressure. Various experiments have been conducted under ambient pressure; their results can be compared with those of theoretical calculations to obtain insights into Dirac electron systems. However, structural disorder peculiar to the STF molecules in the solid-state has prevented any type of theoretical calculation of the states. In this study, we report a new method for calculating intermolecular interactions in disordered systems based on the extended Hückel approximation. This method enables band calculations, suggesting that this material is a rare example of a system close to merging. The obtained band structure indicates that the characteristic disorder in the STF solids distributed electrons equally on the sulphur and selenium atoms as if they belong to an imaginary element between sulphur and selenium and are arranged without disorder.
Defense Installation Energy Resilience for Changing Operational Requirements
Authors: Mallery Janice , Van Bossuyt Douglas L. , Pollman Anthony
Published: March 2022

We propose a methodology to determine the impact of different potential mission scenarios upon energy resilience for mission-critical loads attached to a military base’s microgrid infrastructure. The proposed methodology applies to any installation with changing operational states that has energy-resilience requirements. The proposed methodology may be used by energy managers to account for potential mission scenarios that a base may be part of, followed by assessing the microgrid energy resilience to supply the critical loads for said mission scenarios, especially where the external grid power may be unavailable and/or damage to microgrid components may be present. In the event a microgrid design is unable to provide sufficient electrical energy, distributed energy resources and energy storage systems including renewable energy resources may be added to improve energy resilience. A case study is conducted on a fictitious representative military base, microgrid design, and changing mission demands to demonstrate the application of the proposed methodology. This article contributes a methodology for energy managers to evaluate energy resilience using microgrids by accounting for potential mission scenarios, their energy requirements, resulting energy preparedness, and recommendations for improvement, as necessary.
Successfully Managed Respiratory Insufficiency in a Patient with a Novel Pathogenic Variant of the BMPER Gene: A Case Report
Authors: Park Ho Eun , Yoon Jin A. , Shin Yong Beom
Published: March 2022

Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER) gene mutation presents a disease spectrum ranging from a mild type of ischiospinal dysostosis (ISD) to a more severe type of diaphanospondylodysostosis (DSD). It is known that BMPER gene mutations are very rare, and their resulting clinical manifestations, including musculoskeletal modifications, appear in a spectrum of various types and severity levels. With the development of genetic diagnosis, case reports of patients with specific mutations in the BMPER gene have been published. The most commonly known clinical features are kidney structural problems, including neuroblastoma and renal cysts. Meanwhile, respiratory failure is a common and fatal symptom for patients with BMPER gene mutation, but it does not appear to have been well evaluated or managed so far. We report a case of a confirmed novel mutation of c.1750delT (p.Cys584fs) in the BMPER gene in a female adolescent patient and highlight the importance of the regular assessment of respiratory failure for successful management of this condition.
Novel Usefulness of Krebs von den Lungen 6 (KL-6) with Hemoglobin and Lactate Dehydrogenase for Assessing Bone Marrow Fibrosis
Authors: Nam Minjeong , Hur Mina , Park Mikyoung , Kim Hanah
Published: March 2022

Bone marrow fibrosis (BMF) is manually assessed by reticulin and trichrome stain of bone marrow (BM) biopsy and graded on a semi-quantitative scale. Krebs von den Lungen 6 (KL-6) and Mac-2 binding protein glycosylation isomer (M2BPGi) are known to be associated with lung and liver fibrosis, respectively. We explored the usefulness of KL-6 and M2BPGi to assess BMF. A total of 250 patients who underwent BM biopsy with hematologic or non-hematologic diseases were included, and 42 patients with lung and liver diseases were excluded. The patients’ data, including age, sex, diagnosis, white blood cell, hemoglobin (Hb), platelet, and lactate dehydrogenase (LDH) were collected. Measured KL-6 and M2BPGi levels were compared with reticulin grade (RG) (grade 0–3). KL-6 levels were significantly elevated with an increase in RG, but M2BPGi did not show a significant difference. Hb, LDH, or KL-6 were independent predictors for BMF (odds ratio: 1.96, 2.26, 2.91, respectively), but showed poor predictive ability (area under the curve [AUC] 0.62, 0.61, 0.60, respectively). The combination of Hb, LDH, and KL-6 showed a significantly improved predictive ability for BMF (AUC 0.73; integrated discrimination improvement 0.057; category-free net reclassification improvement 0.625). This is the first study to evaluate the usefulness of KL-6 for assessing BMF. The combination of Hb, LDH, and KL-6 would be an objective and relevant biomarker approach and be applied to risk stratification for BMF.
“Someone Like Anyone Else”: A Qualitative Exploration of New Zealand Health Professional Students’ Understanding of Disability
Authors: Ravichandran Sadhana , Calder Allyson , Ingham Tristram , Jones Bernadette , Perry Meredith
Published: March 2022

Background: One in four New Zealanders identify as disabled. Disabled people, including Māori (the indigenous people of New Zealand (NZ)), experience health disparities. Systemic and individual health professional (HP) biases are factors that may affect health outcomes. Disability education is a means for improving attitudes and behaviors towards disabled people. The objective of this study was to explore NZ HP students’ understanding of disability and health-related concepts. Methods: HP students from one tertiary institution in NZ were interviewed through Zoom video call about their understanding of disability and health. A relativism paradigm and contextualism epistemology (underpinned by the socio-ecological model) shaped the reflexive thematic analysis. Transcripts were analyzed at a deductive and latent level. Results: Nine HP participants, from different professional courses and cultural backgrounds, were interviewed. Three main themes influenced participants’ understanding of disability: life experiences, professional education, and societal exposure. Participants who had more experience with disabled people had a deeper and more nuanced appreciation of the challenges disabled people face in accessing health services and obtaining equitable health outcomes. Cultural background also influenced the participants’ understanding of disability. Participants preferred more experiential learning methods to improve their knowledge of disability concepts. Lastly, expectations of inclusion are determined by observing social norms. Conclusion: Participants reported learning just a few models of disability. The HP students predominantly came from a perspective of ensuring equality rather than equity. There was limited recognition of the systemic biases that exist within multiple social determinants and how these perpetuate health inequities for disabled people. A socio-ecological consideration of disability throughout the curricula, self-reflection, acknowledging systemic bias, and proactively including disabled people as HP students and teachers are potential means for addressing health inequities.
Effects of Urbanization Intensity on the Distribution of Black Carbon in Urban Surface Soil in South China
Authors: Wang Min , Liu Xiaodong , Wu Wenkun , Zeng Huixian , Liu Mengyun , Xu Guoliang
Published: March 2022

Rapid urbanization causes the accumulation of large amounts of pollutants, including heavy metals, organic pollutants, and black carbon (BC). BC is the carbonaceous residue generated from the incomplete combustion of fossil fuels and biomass. It plays an important role on the migration of heavy metals and organic pollutants, as well as soil carbon sequestration. BC accumulation due to human activities greatly affects the global carbon budget, helps to drive climate change, and damages human health. To date, few studies have examined how the intensity of urbanization affects the distribution of BC in soils in urban areas. Therefore, the objective of this study is to determine the effects of urbanization intensity on the spatial distribution and content of BC in urban surface soil. We collected samples from 55 sites in South China and used a multi-scale geographical regression model to evaluate the impact of the interference intensity of urbanization on the amount and distribution of BC. Our results showed that the BC content was significantly higher in urban areas (9.74 ± 1.18 g kg−1) than in rural areas (2.94 ± 0.89 g kg−1) and that several urban parks with a higher interference intensity were hotspots of BC accumulation, suggesting that urbanization promoted BC accumulation. Our model revealed that road density was significantly and positively correlated with BC accumulation. Because there are more cars driving in areas with high road density, vehicle emissions may be one of the causes of BC accumulation. Our results also indicated that the impact of urbanization intensity on the BC distribution was sensitive to sampling density.
Modeling Anaerobic Co-Digestion of Corn Stover Hydrochar and Food Waste for Sustainable Biogas Production
Authors: Shaba Mohammed Ibrahim , Na Risu , Shimizu Naoto
Published: March 2022

Despite the importance of the biodegradability of lignocellulose biomass, few studies have evaluated the lignocellulose biomass digestion kinetics and modeling of the process. Anaerobic digestion (AD) is a mature energy production technique in which lignocellulose biomass is converted into biogas. However, using different organic waste fractions in AD plants is challenging. In this study, lignocellulose biomass (corn stover hydrochar) obtained from hydrothermal carbonization at a temperature, residential time, and biomass/water ratio of 215 °C, 45 min, and 0.115, respectively, was added to the bioreactor as a substrate inoculated with food waste and cow dung to generate biogas. A state–space AD model containing one algebraic equation and two differential equations was constructed. All the parameters used in the model were dependent on the AD process conditions. An adaptive identifier system was developed to automatically estimate parameter values from input and output data. This made it possible to operate the system under different conditions. Daily cumulative biogas production was predicted using the model, and goodness-of-fit analysis indicated that the predicted biogas production values had accuracies of >90% during both model construction and validation. Future work will focus on the application of modeling predictive control into an AD system that would comprise both models and parameters estimation.
Numerical Valuation of European and American Options under Fractional Black-Scholes Model
Authors: Yang Pei , Xu Zuoliang
Published: March 2022

In this paper, we investigate the numerical valuation of European and American options under the time fractional Black-Scholes model. We first apply a coordinate stretching transformation to the asset price so that the spatial region can focus on the vicinity of singularities, which are usually found in the payoff function. The radial basis function finite difference method is used for the spatial discretization, and the improved L1 method is used to deal with the reduced order of convergence for the nonsmooth initial data. We use the operator splitting method for solving the linear complementary problem of American options. The proposed scheme leads to a sparse linear system which is trivial to solve. Moreover, the stability of the proposed numerical scheme is analyzed using Fourier analysis. Numerical experiments demonstrate the accuracy and efficiency of the proposed method.
Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation
Authors: Suhail Muhammad , Shao Yu-Fang , Vu Quoc Lam , Wu Pao-Chu
Published: March 2022

In the current research work, pH-sensitive hydrogels were prepared via a free radical polymerization technique for the targeted delivery of 5-aminosalicylic acid to the colon. Various proportions of chitosan, β-Cyclodextrin, and acrylic acid were cross-linked by ethylene glycol dimethacrylate. Ammonium persulfate was employed as an initiator. The development of a new polymeric network and the successful encapsulation of the drug were confirmed by Fourier transform infrared spectroscopy. Thermogravimetric analysis indicated high thermal stability of the hydrogel compared to pure chitosan and β-Cyclodextrin. A rough and hard surface was revealed by scanning electron microscopy. Similarly, the crystallinity of the chitosan, β-Cyclodextrin, and fabricated hydrogel was evaluated using powder X-ray diffraction. The swelling and drug release studies were performed in both acidic and basic medium (pH 1.2 and 7.4, respectively) at 37 °C. High swelling and drug release was observed at pH 7.4 as compared to pH 1.2. The increased incorporation of chitosan, β-Cyclodextrin, and acrylic acid led to an increase in porosity, swelling, loading, drug release, and gel fraction of the hydrogel, whereas a decrease in sol fraction was observed. Thus, we can conclude from the results that a developed pH-sensitive network of hydrogel could be employed as a promising carrier for targeted drug delivery systems.
Development and Cross-Species Transferability of Novel Genomic-SSR Markers and Their Utility in Hybrid Identification and Trait Association Analysis in Chinese Cherry
Authors: Liu Zhenshan , Zhang Jing , Wang Yan , Wang Hao , Wang Lei , Zhang Lu , Xiong Muran , He Wen , Yang Shaofeng , Chen Qing , Chen Tao , Luo Ya , Zhang Yong , Tang Haoru , Wang Xiaorong
Published: March 2022

Chinese cherry (Cerasus pseudocerasus (Lindl.) G.Don) is an economically important tetraploid fruiting cherry species native to China. Simple sequence repeats (SSRs)—due to their codominance, polymorphism, and stability—have been widely applied in genetic identification and trait-association analysis. In this study, using comparative genomics strategy and the data of one high-quality whole genome and seven preliminarily assembled genome sequences, we constructed a database containing 25,779 polymorphic SSR loci to efficiently develop novel markers. Sixty-four SSR loci covering eight linkage groups were selected to design primer pairs. Sixty (93.75%) primer pairs yielded specific bands and 32 (50.00%) exhibited moderate-to-high levels of informativeness (PIC ranging from 0.264 to 0.728) in 94 Chinese cherry accessions. A total of 38 primer pairs exhibited high transferability across 13 Cerasus taxa. The marker SAUCps203 was species-specific in C. pseudocerasus by checking with 114 accessions from Cerasus and 16 relatives, suggesting its potential application in accurate identification of Chinese cherry or its interspecific hybrid. Moreover, 1081 out of 1122 individuals from three cross F1 populations of Chinese cherry were identified as true hybrid offspring by using only five SSR markers. Trait association analysis suggested that 20 SSR loci were significantly associated with soluble solids and fruit size, with explained phenotypic variance ranging from 9.02% to 26.35%. This study will provide a basis for SSR-based germplasm identification and further marker-assisted selection (MAS) of Chinese cherry.
Efficacy and Safety of Ivermectin and Hydroxychloroquine in Patients with Severe COVID-19: A Randomized Controlled Trial
Authors: Beltran Gonzalez Jose Lenin , González Gámez Mario , Mendoza Enciso Emanuel Antonio , Esparza Maldonado Ramiro Josue , Hernández Palacios Daniel , Dueñas Campos Samuel , Robles Itzel Ovalle , Macías Guzmán Mariana Jocelyn , García Díaz Andrea Lucia , Gutiérrez Peña César Mauricio , Martinez Medina Lucila , Monroy Colin Victor Antonio , Arreola Guerra Jose Manuel
Published: March 2022

During the first year of the COVID-19 pandemic, unauthorized drugs were widely used. Ivermectin and hydroxychloroquine are drugs that inhibit viral replication in vitro and that have been used in several medical centers. This clinical trial analyzes their efficacy in hospitalized patients with moderate COVID-19. Methods: This a controlled, clinical, randomized, double-blind trial that included hospitalized patients with COVID-19-induced pneumonia, without severe respiratory failure. Patients were randomized to one of three groups: Group 1—hydroxychloroquine, 400 mg every 12 h on the first day and, subsequently, 200 mg every 12 h for 4 days; Group 2—ivermectin, 12 mg or 18 mg, according to patient weight; and Group 3—placebo. At inclusion, blood samples for arterial blood gases and biochemical markers were obtained. The primary outcome was established as the length of stay due to patient improvement and the rate of respiratory deterioration or death. Results: During the month of August 2020, the admission of patients requiring hospitalization mostly encompassed cases with severe respiratory failure, so we ended the recruitment process and analyzed the data that was available at the time. One hundred and six (106) patients with an average age of 53 yrs (±16.9) were included, with a greater proportion of males (n = 66, 62.2%). Seventy-two percent (72%) (n = 76) had an associated comorbidity. Ninety percent (90%) of patients were discharged due to improvement (n = 96). The average duration of hospitalization was 6 days (IQR, 3–10). No difference in hospitalization duration was found between the treatment groups (Group1: 7 vs. Group 2: 6 vs. Group 3: 5, p = 0.43) nor in respiratory deterioration or death (Group 1: 18% vs. Group 2: 22.2% vs. Group 3: 24.3%, p = 0.83). Conclusions: In non-critical hospitalized patients with COVID-19 pneumonia, neither ivermectin nor hydroxychloroquine decreases the number of in-hospital days, respiratory deterioration, or deaths.
Power Distance Belief and Workplace Communication: The Mediating Role of Fear of Authority
Authors: Dai Yuwan , Li Hao , Xie Wenting , Deng Tianyi
Published: March 2022

Power distance is the degree of acceptance of unequal distribution of power in societies. In a high power distance context, the acceptance of inequality conflicts with the operation of modern organizations, which causes obstacles to workplace communication or even triggers workplace accidents due to ineffective communication. We conducted four studies (N = 1063) to explore the relations between and mechanisms of power distance belief and workplace communication. In Study 1, the participants with high power distance belief had ineffective workplace communication—specifically ineffective communication with superiors—but no difference in communication with subordinates and colleagues. We further focused on the mechanism underlying the relationship between power distance belief and communication with superiors. A questionnaire study (Study 2) was conducted in three stages over a three-month period, and an experimental study (Study 3) indicated that fear of authority mediated the negative effect of high power distance on communication with superiors. A cross-culture study (Study 4) re-tested the hypotheses among Chinese and U.S. participants. This research provides insight into the mechanisms that explain the relationship between power distance belief and workplace communication, indicating that fear of authority is significant. Organizations should pay attention to power distance belief and fear of authority, as they may lead to workplace accidents due to communication disasters.
The Relationship between Emotional Stability, Psychological Well-Being and Life Satisfaction of Romanian Medical Doctors during COVID-19 Period: A Cross-Sectional Study
Authors: Muntean Lorena Mihaela , Nireștean Aurel , Popa Cosmin Octavian , Strete Elena Gabriela , Ghiga Dana Valentina , Sima-Comaniciu Andreea , Lukacs Emese
Published: March 2022

Due to the COVID-19 pandemic, as well as the fast progression of modern society, occupational stress has recently reached alarming levels with consequences for doctors’ psychological well-being. The aim of this study was to analyze the relationship among emotional stability, psychological well-being, and life satisfaction of medical doctors. We conducted a cross-sectional study on 280 medical doctors from Romania between February 2021 and September 2021, in the period between the third and fourth pandemic waves, who were evaluated by the DECAS, ASSET, and Satisfaction with Life scales. Our results showed that emotional stability is negatively correlated with psychological well-being (r = −0.526, p < 0.000) and positively correlated with life satisfaction (r = 0.319, p < 0.0001). Between psychological well-being and life satisfaction, we found a negative correlation (r = −0.046, p < 0.001). This study shows that there is a correlation among emotional stability, psychological well-being, and life satisfaction, which is why it can be considered that Romanian doctors have generated coping mechanisms during the COVID-19 pandemic.
An Investigation into the Physical Activity Experiences of People Living with and beyond Cancer during the COVID-19 Pandemic
Authors: Pringle Andy , Kime Nicky , Zwolinsky Stephen , Rutherford Zoe , Roscoe Clare
Published: March 2022

This study investigated the physical activity experiences of people living with and beyond cancer (PLWBC) during the COVID-19 pandemic. Participants attended the cancer and rehabilitation exercise (CARE) programme delivered by a football community trust. Staff (n = 2) and participants (n = 9) attended semi-structured interviews investigating the PA participation and experiences of attending/delivering different modes of CARE, including exercise classes delivered outdoors and delivered online. Interviews also investigated participant aspirations for returning to CARE sessions delivered in person indoors. The findings show that the COVID-19 pandemic and government restrictions impacted on PA participation, yet exercise sessions provided via CARE offered participants an important opportunity to arrest their inactivity, keep active and maintain their fitness and functionality. Barriers to participation of CARE online included access to IT infrastructure, internet connectivity and IT skills and comfort using IT. Regarding CARE outdoors, the weather, range of equipment, variety of exercises and the lack of toilets and seats were barriers. In the different CARE modes, the skills of delivery staff who were sensitive to the needs of participants, social support, and the need for participants to maintain good mental and social health were important facilitators for engagement and are considerations for programme delivery. CARE helped PLWBC to keep physically active.
Coenzyme A Restriction as a Factor Underlying Pre-Eclampsia with Polycystic Ovary Syndrome as a Risk Factor
Authors: Hodgman Charlie , Khan Gulafshana Hafeez , Atiomo William
Published: March 2022

Pre-eclampsia is the most common pregnancy complication affecting 1 in 20 pregnancies, characterized by high blood pressure and signs of organ damage, most often to the liver and kidneys. Metabolic network analysis of published lipidomic data points to a shortage of Coenzyme A (CoA). Gene expression profile data reveal alterations to many areas of metabolism and, crucially, to conflicting cellular regulatory mechanisms arising from the overproduction of signalling lipids driven by CoA limitation. Adverse feedback loops appear, forming sphingosine-1-phosphate (a cause of hypertension, hypoxia and inflammation), cytotoxic isoketovaleric acid (inducing acidosis and organ damage) and a thrombogenic lysophosphatidyl serine. These also induce mitochondrial and oxidative stress, leading to untimely apoptosis, which is possibly the cause of CoA restriction. This work provides a molecular basis for the signs of pre-eclampsia, why polycystic ovary syndrome is a risk factor and what might be done to treat and reduce the risk of disease.
Prediction of Railway Track Condition for Preventive Maintenance by Using a Data-Driven Approach
Authors: Vale Cecília , Simões Maria Lurdes
Published: March 2022

For scheduling track maintenance, infrastructure managers perform inspections to assess the track condition. When the irregularities are higher than the threshold limits, a track has a defect that should be corrected to avoid future failures or traffic disruption. Scheduling maintenance actions contribute to reliability and availability but demand the prediction of the evolution of track degradation. In recent years, several degradation models have been defined to forecast geometrical evolution over time and/or tonnage, mainly for heavy rail systems. Nevertheless, most of those models have limitations when dealing with measured data collected in different time intervals as happens in reality. To overcome this problem, a data-driven model based on the logistic binary function is presented and validated with real inspection measurements. The results prove that the model has a 91.1% success rate, an excellent discrimination ability, and a high sensitivity, classifying correctly 84.1% of inspections in need of maintenance. The model also has high specificity as it classifies 94.5% of inspections with no demand of maintenance action. The model is easy to implement, which is also an advantage for the track asset management with guaranty of excellent sensitivity and discrimination.
Similar Bacterial Communities among Different Populations of a Newly Emerging Invasive Species, Tuta absoluta (Meyrick)
Authors: Wang Hao , Xian Xiaoqing , Gu Yujuan , Castañé Cristina , Arnó Judit , Wu Suran , Wan Fanghao , Liu Wanxue , Zhang Guifen , Zhang Yibo
Published: March 2022

Microorganisms in the guts of insects enhance the adaptability of their hosts with different lifestyles, or those that live in different habitats. Tuta absoluta is an invasive pest that is a serious threat to tomato production in China. It has quickly spread and colonized Xinjiang, Yunnan and other provinces and regions. We used Illumina HiSeq next generation sequencing of the 16S rRNA gene to study and analyze the composition and diversity of the gut microbiota of three geographical populations of T. absoluta. At the phylum level, the most common bacteria in T. absoluta across all three geographical populations were Proteobacteria and Firmicutes. An uncultured bacterium in the Enterobacteriaceae was the dominant bacterial genus in the T. absoluta gut microbiotas. There were no significant differences in alpha diversity metrics among the Spanish, Yunnan and Xinjiang populations. The structures of the gut microbiota of the three populations were similar based on PCoA and NMDS results. The results confirmed that the microbial structures of T. absoluta from different regions were similar.
In Vivo Methods to Monitor Cardiomyocyte Proliferation
Authors: Young Alexander , Bradley Leigh A. , Wolf Matthew J.
Published: March 2022

Adult mammalian cardiomyocytes demonstrate scarce cycling and even lower proliferation rates in response to injury. Signals that enhance cardiomyocyte proliferation after injury will be groundbreaking, address unmet clinical needs, and represent new strategies to treat cardiovascular diseases. In vivo methods to monitor cardiomyocyte proliferation are critical to addressing this challenge. Fortunately, advances in transgenic approaches provide sophisticated techniques to quantify cardiomyocyte cycling and proliferation.
Numerical Modelling on the Local Design of a Marine Bonded Composite Hose (MBCH) and Its Helix Reinforcement
Authors: Amaechi Chiemela Victor , Chesterton Cole , Butler Harrison Obed , Gu Zewen , Odijie Agbomerie Charles
Published: March 2022

With the exploration of oil trending deeper, from shallow waters to deep waters, there is a corresponding increase in the need for more sustainable conduit materials for production purposes. Secondly, there is an increasing demand for more energy from fossil fuels that are excavated with less expensive technologies. As such, short-service hoses are applied in the offshore industry. The industry has utilised composites to improve the material and solve different offshore issues. This study analyses a current problem facing the oil and gas industry at present regarding hose usage. This paper presents results from the local design and analyses of a marine bonded composite hose (MBCH), to present its result visualisations and nephographs. In this paper, the local design of a 1 m section of an MBCH was carried out in ANSYS under different loading conditions. Some design criteria were set, and other load conditions were used to simulate the model using the finite element model (FEM) approach. From this study, composites could be considered to improve conventional marine hoses. The findings of the study include the identification of linear wrinkling and damage sites on the helix reinforcement. An experimental investigation and proper content test are recommended for the bonded hose. Additionally, highly reinforced hose ends are recommended in the ends of the MBCH, as they had maximum stress and strain values. It is recommended that hose operations like reeling must be conducted under operational pressure and not design pressure, as the study shows that the design pressure could be high on the hose model.
AoSsk1, a Response Regulator Required for Mycelial Growth and Development, Stress Responses, Trap Formation, and the Secondary Metabolism in Arthrobotrys oligospora
Authors: Jiang Ke-Xin , Liu Qian-Qian , Bai Na , Zhu Mei-Chen , Zhang Ke-Qin , Yang Jin-Kui
Published: March 2022

Ssk1, a response regulator of the two-component signaling system, plays an important role in the cellular response to hyperosmotic stress in fungi. Herein, an ortholog of ssk1 (Aossk1) was characterized in the nematode-trapping fungus Arthrobotrys oligospora using gene disruption and multi-phenotypic comparison. The deletion of Aossk1 resulted in defective growth, deformed and swollen hyphal cells, an increased hyphal septum, and a shrunken nucleus. Compared to the wild-type (WT) strain, the number of autophagosomes and lipid droplets in the hyphal cells of the ΔAossk1 mutant decreased, whereas their volumes considerably increased. Aossk1 disruption caused a 95% reduction in conidial yield and remarkable defects in tolerance to osmotic and oxidative stress. Meanwhile, the transcript levels of several sporulation-related genes were significantly decreased in the ΔAossk1 mutant compared to the WT strain, including abaA, brlA, flbC, fluG, and rodA. Moreover, the loss of Aossk1 resulted in a remarkable increase in trap formation and predation efficiency. In addition, many metabolites were markedly downregulated in the ΔAossk1 mutant compared to the WT strain. Our results highlight that AoSsk1 is a crucial regulator of asexual development, stress responses, the secondary metabolism, and pathogenicity, and can be useful in probing the regulatory mechanism underlying the trap formation and lifestyle switching of nematode-trapping fungi.
Synchronized Efficacy and Mechanism of Alkaline Fertilizer and Biocontrol Fungi for Fusariumoxysporum f. sp. cubense Tropical Race 4
Authors: Li Yuanqiong , Jiang Shuting , Jiang Jiaquan , Gao Chengxiang , Qi Xiuxiu , Zhang Lidan , Sun Shaolong , Dai Yinhai , Fan Xiaolin
Published: March 2022

The purpose of this study was to determine the effect and mechanism of alkaline fertilizer, bio-control fungi, and their synergistic application on control of Fusarium Tr4 incidence. Synchronized use of the alkaline fertilizer and biocontrol fungi eliminates rhizome browning and reduces the incidence rate of banana Fusarium wilt. The incidence of yellow leaves (ratio of yellow leaf to total leaf) and disease index in +Foc Tr4 CF treatment were the same (65%), while incidence of yellow leaves and disease index in +Foc Tr4 AFBCF were 31% and 33%, respectively. Under the stress of Foc Tr4 infection, the synergistic utilization of the alkaline fertilizer and biocontrol fungi would raise the activities of peroxidase, catalase and superoxide dismutase in banana roots. The root activity of banana was also increased. As a result, the banana height and stem diameter increments, shoot and root dry weight, accumulation of N, P and K in banana plants had been increased. The efficacy of the synergistic application of alkaline fertilizer and biocontrol fungi was not only reducing Foc Tr4 pathogen colonization and distribution in banana plants, but also preventing tylosis formation in vascular vessel effectively. Therefore, the normal transport of water and nutrients between underground and aboveground is ensured.
Effectiveness of Human–Artificial Intelligence Collaboration in Cephalometric Landmark Detection
Authors: Le Van Nhat Thang , Kang Junhyeok , Oh Il-Seok , Kim Jae-Gon , Yang Yeon-Mi , Lee Dae-Woo
Published: March 2022

Detection of cephalometric landmarks has contributed to the analysis of malocclusion during orthodontic diagnosis. Many recent studies involving deep learning have focused on head-to-head comparisons of accuracy in landmark identification between artificial intelligence (AI) and humans. However, a human–AI collaboration for the identification of cephalometric landmarks has not been evaluated. We selected 1193 cephalograms and used them to train the deep anatomical context feature learning (DACFL) model. The number of target landmarks was 41. To evaluate the effect of human–AI collaboration on landmark detection, 10 images were extracted randomly from 100 test images. The experiment included 20 dental students as beginners in landmark localization. The outcomes were determined by measuring the mean radial error (MRE), successful detection rate (SDR), and successful classification rate (SCR). On the dataset, the DACFL model exhibited an average MRE of 1.87 ± 2.04 mm and an average SDR of 73.17% within a 2 mm threshold. Compared with the beginner group, beginner–AI collaboration improved the SDR by 5.33% within a 2 mm threshold and also improved the SCR by 8.38%. Thus, the beginner–AI collaboration was effective in the detection of cephalometric landmarks. Further studies should be performed to demonstrate the benefits of an orthodontist–AI collaboration.
Patient Activation: The Cornerstone of Effective Self-Management in Chronic Kidney Disease?
Authors: Lightfoot Courtney J. , Nair Devika , Bennett Paul N. , Smith Alice C. , Griffin Anthony D. , Warren Madeleine , Wilkinson Thomas J.
Published: March 2022

The importance of patient activation (i.e., the knowledge, skills, and confidence one has in managing one’s own healthcare) in people with long-term conditions, including kidney disease, is growing. Enabling and empowering patients to take a more active role in their health and healthcare is the focus of person-centred care. Patient activation is recognised as a key construct of self-management, as to effectively self-manage a long-term condition, it is required to enable individuals to actively participate in treatment decisions, prevent complications, and manage risk factors. Identifying an individual’s level of activation can help guide and tailor care, and interventions aimed at increasing patient activation may improve patient engagement and health outcomes. In this review, we explore the concepts of patient activation and self-management, the relationship between patient activation and self-management, interventions aimed at improving these, and what these mean to people living with kidney disease.
Anti-Inflammatory Dietary Approach to Prevent the Development and Progression of Non-Alcoholic Fatty Liver Diseases
Authors: Portius Dorothea
Published: March 2022

Non-alcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide and is associated with insulin resistance, increased visceral fat mass, and cardiovascular problems. Lifestyle factors such as sedentary lifestyle, chronic stress, obesogenic environment as well as a Western pattern diet are main contributors to the development and progression of this disease. In particular, the diet plays a pivotal role. An unhealthy diet including high consumption of red and processed meats, refined carbohydrates, simple sugars, highly processed foods with food additives and conservatives are lighting the fire for a low-grade inflammation. If other risk factors come into play, metabolic and hormonal derangement may occur, leading to the increase in visceral fat, gut dysbiosis and leaky gut, which stoke the inflammatory fire. Thus, lifestyle interventions are the most effective approach to quell the inflammatory processes. An anti-inflammatory and low-glycemic diet named the GLykLich diet, which includes whole and unprocessed foods, may reduce the risk of increased morbidity and mortality. The GLykLich diet suggests a meal consisting of complex carbohydrates (fiber), good quality of protein and healthy fats (DHA/EPA), and is rich in secondary plant products. There is no single nutrient to prevent the progression of NAFLD, rather, it is the complexity of substances in whole unprocessed foods that reduce the inflammatory process, improve metabolic state, and thus reverse NAFLD.
Ion Dynamics at the Carbon Electrode/Electrolyte Interface: Influence of Carbon Nanotubes Types
Authors: Escobar-Teran Freddy , Perrot Hubert , Sel Ozlem
Published: March 2022

Electrochemical quartz crystal microbalance (EQCM) and AC-electrogravimetry methods were employed to study ion dynamics in carbon nanotube base electrodes in NaCl aqueous electrolyte. Two types of carbon nanotubes, Double Wall Carbon Nanotube (DWCNT) and Multi Wall Carbon Nanotube (MWCNT), were chosen due to their variable morphology of pores and structure properties. The effect of pore morphology/structure on the capacitive charge storage mechanisms demonstrated that DWCNT base electrodes are the best candidates for energy storage applications in terms of current variation and specific surface area. Furthermore, the mass change obtained via EQCM showed that DWCNT films is 1.5 times greater than MWCNT films in the same potential range. In this way, the permselectivity of DWCNT films showed cation exchange preference at cathode potentials while MWCNT films showed anion exchange preference at anode potentials. The relative concentration obtained from AC-electrogravimetry confirm that DWCNT base electrodes are the best candidates for charge storage capacity electrodes, since they can accommodate higher concentration of charged species than MWCNT base electrodes.
Highly Transparent and Polarization-Maintained Terahertz Plasmonic Metamaterials Based on Metal-Wire-Woven Hole Arrays: Fundamentals and Characterization of Transmission Spectral Peaks
Authors: You Borwen , Lu Ja-Yu , Chen Po-Lun , Hung Tun-Yao , Yu Chin-Ping
Published: March 2022

Metal-hole-supported terahertz (THz) waves through the structure of a metal-wire-woven hole array (MWW-HA) present high-frequency-passed transmittance spectra of one plasmonic metamaterial with artificial plasmonic frequencies, which are inversely proportional to metal-hole widths. For the transmitted THz waves of MWW-HA, transverse-electric (TE) and transverse-magnetic (TM) waveguide modes mix within a symmetric metal-hole boundary. THz resonance waves transversely crossing the holes of MWW-HA are experimentally characterized with spectral peaks in the frequency range of 0.1–2 THz that are correlated with aperture sizes, unit-cell-hole widths, metal-wire thicknesses, and wire-bending angles. The metal-hole-transported resonance waves of MWW-HA are dominated by TE waveguide modes instead of TM ones because a hole width of MWW-HA is approximate to the half wavelength of a resonance wave. The round metal edges of the woven metal wires can minimize the effective optical length of a thick metal hole to transmit THz resonance waves, thereby resulting the smallest rotation angle of linear polarization and high transmittance up to 0.94. An MWW-HA structure is therefore reliable for supporting metal-hole resonance waves with low resistance, whereas a metal-slab-perforated hole array cannot achieve the same result.