bluuebunny/crossref_metadata_2025 huggingface dataset:
Simultaneous Occurrence of Multiple Neoplasms in Children with Cancer Predisposition Syndromes: Collaborating with Abnormal Genes
Authors: Telman Gabriela , Strauss Ewa , Sosnowska-Sienkiewicz Patrycja , Halasz Magdalena , Januszkiewicz-Lewandowska Danuta
Published: July 2023

The identification of cancer predisposition syndromes (CPSs) plays a crucial role in understanding the etiology of pediatric cancers. CPSs are genetic mutations that increase the risk of developing cancer at an earlier age compared to the risk for the general population. This article aims to provide a comprehensive analysis of three unique cases involving pediatric patients with CPS who were diagnosed with multiple simultaneous or metachronous cancers. The first case involves a child with embryonal rhabdomyosarcoma, nephroblastoma, glioma, and subsequent medulloblastoma. Genetic analysis identified two pathogenic variants in the BRCA2 gene. The second case involves a child with alveolar rhabdomyosarcoma, Xanthogranuloma Juvenile, gliomas, and subsequent JMML/MDS/MPS. A pathogenic variant in the NF1 gene was identified. The third case involves a child with pleuropulmonary blastoma and pediatric cystic nephroma/nefroblastoma in whom a pathogenic variant in the DICER1 gene was identified. Multiple simultaneous and metachronous cancers in pediatric patients with CPSs are a rare but significant phenomenon. Comprehensive analysis and genetic testing play crucial roles in understanding the underlying mechanisms and guiding treatment strategies for these unique cases. Early detection and targeted interventions are crucial for improving outcomes in these individuals.
Long-Term Assessment of PurpleAir Low-Cost Sensor for PM2.5 in California, USA
Authors: Farooqui Zuber , Biswas Jhumoor , Saha Jayita
Published: July 2023

Regulatory monitoring networks are often too sparse to support community-scale PM2.5 exposure assessment while emerging low-cost sensors have the potential to ﬁll in the gaps. Recent advances in air quality monitoring have produced portable, easy-to use, low-cost, sensor-based monitors, which has given a new dimension to the air pollutant monitoring and has democratized the air quality monitoring process by making monitors and results directly available at community level. This study used PurpleAir(c) sensors for PM2.5 assessment in California, USA. Evaluation of PM2.5 from sensors included Quality Assurance & Quality Control (QAQC) procedures, assessment with respect to reference monitored PM2.5 concentrations, and formulation of a decision support system integrating these observations using geostatistical techniques. The hourly and daily average observed PM2.5 concentrations from PurpleAir monitors followed the trends of observed PM2.5 at regulatory monitors. PurpleAir monitored PM2.5 also captured the peak PM2.5 concentrations due to incidents like forest fire. In comparison with reference monitored PM2.5 levels, it was found that PurpleAir PM2.5 concentrations were mostly higher. The most important reason for PurpleAir higher PM2.5 concentrations was the inclusion of moisture or water vapor as aerosol in contrast to measurements of PM2.5 excluding water content in FEM/FRM and non-FEM/FRM monitors. On long term assessment (2016-2020), R2 was between 0.54 and 0.86 at selected collocated PurpleAir and regulatory monitors for hourly PM2.5 concentrations. Past research studies have been conducted for mostly shorter time periods (<3-4 months) that resulted in higher R2 values between 0.80 to 0.98. This study aims to provide reasonable estimations of PM2.5 concentrations with high spatiotemporal resolutions based on statistical models using PurpleAir measurements. The methods of Kriging and IDW, geostatistical interpolation techniques, showed similar spatio-temporal patterns. Overall, this study revealed that low-cost, sensor based PurpleAir sensors could be effective and reliable tools for episodic and long-term ambient air quality monitoring.
Approaching High-Performance TS-1 Zeolites in the Presence of Alkali Metal Ions via Combination of Adjusting pH Value and Modulating Crystal Size
Authors: Li Geng , Fu Kairui , Xu Fulin , Li Tianduo , Wang Yunan , Wang Jingui
Published: July 2023

Lewis acid zeolites play an important role in industrially important green reactions closely related to fine chemicals and biomass conversion. Titanium-doped TS-1 zeolite is a milestone Lewis acid zeolite, which widely uses in industrially significant green oxidation processes with hydrogen peroxide as an oxidant under mild conditions. TS-1 Zeolites are normally synthesized in basic condition under hydrothermal treatment. Up to now, it is still not successful to synthesize active TS-1 Lewis acid zeolite by using inorganic alkali, e.g. NaOH or KOH as base, which are cheaper and more stable compared with quaternary ammonium hydroxide or organic amines used in the traditional synthesis. Here, inorganic base of NaOH was firstly employed in synthesizing active TS-1 zeolites. The crucial factor was the control of adverse effects of sodium cations on the incorporation of active titanium cations. A higher catalytic activity could be achieved by further reducing the size of the TS-1 crystal by seed-added strategy, which could approach the catalytic activity of commercial catalyst while the production cost was much lower than the commercial TS-1 catalysts, indicating great commercial potential and the possibility of preparing other cheap Lewis acid catalysts by using inorganic alkali.
Novel Compounds for the Treatment of Schizophrenia – A Narrative Review
Authors: Diakaki Kalliopi , Miliaras Apostolos , Tsapakis Evangelia Maria , Fountoulakis Konstantinos N
Published: July 2023

Schizophrenia is a chronic neuropsychiatric syndrome with a significant impact on daily function and quality of life. All available guidelines suggest a combined treatment approach with pharmacologic agents and psychological interventions. However, one in three patients is a non-responder, the effect on negative and cognitive symptoms is limited, and many drug-related adverse effects complicate clinical management. As a result, discovering novel drugs for schizophrenia presents a significant challenge for psychopharmacology. This narrative review of the literature aims to present recently approved and newly discovered pharmacological substances for the treatment of schizophrenia as well as their suggested mechanism of action. We discuss seven novel drugs, three of which have been approved by the FDA (Olanzapine/Samidorphan, Lumateperone, and Pimavanserin). The rest are under clinical trial investigation (Ulotaront, CVL-231, Xanomeline/Trospium, Brilaroxazine). Additional basic and clinical research is, however, required not only to improve our understanding of the neurobiology and potential novel targets in schizophrenia treatment but also to establish modern and more effective therapeutical interventions with friendlier side-effect profiles.
In-silico Discovery of Genetic Diversity in Cucumis sativus var. hardwickii: A Wild Relative of Cultivated Cucumber
Authors: Rawat Suniti , Singh Vikas Kumar , Kumar Rahul , Sharma Meenakshi , Delta Anil Kumar , Dhanda Parmdeep Singh , Yadav Alpa , Kaushik Prashant
Published: July 2023

Genome-wide sequencing data play an important role in evaluating the genomic level differences between superior and poor-quality crop plants and improving our understanding of molecular association with desired traits. We analyzed the obtained 92,921,066 raw reads from genome-wide resequencing of Cucumis sativus var. hardwickii through in-silico approaches and mapped to the reference genome of Cucumis sativus to identify the genome-wide single nucleotide polymorphisms (SNPs) and Single nucleotide variations (SNV). Here, we report 19, 74,213 candidate SNPs including 1,33,468 insertions and 1,43,237 deletions and 75 Indels genome-wide. A total of 2228224 identified variants were classified into four classes including 0.01% sequence alteration, 5.94% insertion, 6.37% deletion and 87.66% SNV respectively. These variations can be a major source of phenotypic diversity and sequence variation within the species. During the present study these variants were also utilized to resolve orthologous relationships among the genomes of C. melo and C. sativus var. hardwickii. Overall, the discovery of SNPs and genomic variants may help predict the plant response to certain environmental factors and can be utilized to improve crop plants' economically important traits.
Dynamics of Organic Carbon and Predictive Management Indices in Contrasting Land Use Types on Weathered Soils of Eastern Tanzania
Authors: Mwakipa Dorcasy Johannes , Nassary Eliakira Kisetu
Published: July 2023

This study examined carbon footprint as an indicator of soil health at spatiotemporal scales with different land use types and varying soil depths in Morogoro, representing the eastern agroecological zone of Tanzania. Soils are highly weathered and acidic. The specific objectives were twofold: (1) To quantify soil organic carbon (SOC) at varying soil depths (0–15 cm, 15–30 cm) in contrasting land use types, including tractor cultivated, hand-hoe cultivated, ranch land, and reserved/bare land type; (2) To predict carbon management indices (CMI) of the studied land use types through regresses SOC, carbon pool index (CPI), and lability index (LI) at varying soil depths. Composite soil samples were based on transects of three main plots each (replicates) of 20 m by 50 m. Results showed that land use types and soil depths significantly (P <0.001) affected SOC (3.4%) and CMI (126.3). Hand hoe cultivated land at 0–15 cm recorded CMI of 259.8. Regression analysis showed an increase in CMI ranging from 97% to 99%, with standard error ranging from 2.177 to 46.096. Similar trends, but with disparity magnitudes in regressed parameters provide useful insight into transformations of organic carbon in contrasting land use types.
Expression Profiling of Salt- And Drought-Stress Responsive Genes in Wild Barley (Hordeum spontaneum L.)
Authors: Bakır Melike , Altınkut Uncuoğlu Ahu , Yüksel Özmen Canan , Yılmaz Baydu Funda , Kazan Kemal , Kibar Umut , Schlauch Karen , Cushman John Chandler , Ergül Ali
Published: July 2023

Drought and salinity are among the most important abiotic stress factors that limit the productivity in economically important plants. Although genes from wild relatives or unadapted germplasm have often been used for stress tolerance breeding, only few studies have examined wild relatives to understand the genetic and molecular basis of stress tolerance. In this study, we monitored the changes in gene expression profiles of leaf and root tissues of two wild barleys (Hordeum spontaneum L.) accessions from Israel after treatment with salt (NaCl) and drought (PEG) stress.

We identified a total of 641 differentially expressed genes across 24 conditions (2 accessions, 2 stress conditions, 2 tissues and 3 time points). Our gene expression analyses revealed large numbers of differentially expressed genes in different accessions by different stress treatments. In addition, the number of genes altered in the leaves of stress-exposed plants of both genotypes was higher than those altered in the roots. Interestingly, there was a relatively little overlap between the leaf and the root stress-responsive gene expression patterns, suggesting that different stress-associated processes might be operating in these tissues during stress adaptation.
Overall, our results revealed a number of candidate genes and plant processes associated with stress tolerance in wild barley. Wild barley would be a useful source of new genetic variation for drought and salt stress tolerance. Our results could provide new insights into the mechanisms of drought and salt stress tolerance in wild barley and should be useful for genetic improvement of salt-drought tolerance in cultivated barley.
Magnetic Compression Anastomosis – Past Experience and Current Proposals for Further Development in Pediatric Minimally Invasive Surgery
Authors: Kotlovsky Anatole M. , Muensterer Oliver J. , Nikolaev Vasily V. , Razumovskiy Alexander Y.
Published: July 2023

Originating in the 1970s, Magnetic Compression Anastomosis (MCA) has lately been revisited with a focus on minimal invasive surgery (MIS). The aim of this report is to reappraise our earlier experience with MCA with the intention of facilitating future MCA advancement. A retrospective review was conducted regarding preclinical experiments and clinical trials at a single institution from 1980 through 1995. The reviewed information was compiled and appraised to generate proposals for future MCA use. The experimental studies, including 250 MCA cases in gastrointestinal and urinary tract animal models, demonstrated the technical versatility of MCA as well as the superior biomechanical characteristics in comparison to hand-sewn anastomoses. Clinical trials encompassed 87 MCA procedures in 86 children, 2 to 10 years of age, involving the following techniques: non-operative esophageal recanalization (n=15), non-operative ileostomy undiversion (n=46), Swenson pull-through (n=10), non-operative urethral recanalization (n=5), and extravesical ureterocystoneostomy (n=11). Clinical MCA was found to be successful in over 87% of cases. MCA limitations concerning anastomotic failure and scarring were thought to be mostly due to inadequate magnetic compression. Based on our historic experience, we propose further research on the technical aspects of MCA, along with the biologic aspects of anastomotic tissue remodeling. Magnets should be designed and manufactured for a wide spectrum of pediatric surgical indications, particularly in combination with novel MIS techniques.
Economic Geographical Study of Factors Limiting Foreign Direct Investment in Free Economic Zones of Uzbekistan
Authors: Ahn Young-Jin , Juraev Zuhriddin
Published: July 2023

Uzbekistan, as an emerging national economy, aims to attract foreign direct investment (FDI) to foster the development of its free economic zones (FEZs). While recent policy reforms have enhanced the country's appeal to investors and facilitated the inflow of international capital, challenges persist in attracting investment. This study employs an economic geographical approach to analyze and propose solutions to these obstacles. By examining the spatial patterns of FEZs and FDI through a comprehensive geographical lens, this research utilizes document analysis as an alternative to empirical analysis, considering the broader context rather than focusing on a specific FEZ. The findings reveal that the insufficiency of an innovation-driven environment, logistical systems, energy resource-related issues, among others, negatively impact the inflow of FDI into FEZs. Moreover, the study underscores the significance of economic geography in understanding these factors. Finally, relevant insights and recommendations are provided from an economic geographical perspective.
A Drag Reduction Study on The Aerodynamics of The Irish Taxi Sign
Authors: Connolly Michael Gerard , O'Rourke Malachy , Ivankovic Alojz
Published: July 2023

This comprehensive study focused on the standard taxi sign used in Ireland, its impact on drag production, fuel expenses, and CO2 emissions. Experimental analysis revealed that the conventional taxi sign significantly increased drag, especially when mounted on streamlined vehicles such as saloon cars, due to flow separation issues on the rear roof and rear windshield. Longitudinal reorientation of the sign offered a 14-fold reduction in drag increase compared to the traditional placement. It was found that positioning the sign in the middle of the roof offered the greatest fuel efficiency. Furthermore, the study estimated that implementing longitudinal repositioning on all Irish taxi signs could save drivers approximately 832 per year and reduce national CO2 emissions by a substantial 22,464 tonnes annually. Comparative analyses with international taxi signs demonstrated that the Irish sign had significantly larger drag contributions, emphasizing the need for improved aerodynamics. To address the inherent drag issue, the study explored novel appendable devices and proposed alternative taxi sign designs. Among the tested solutions, a magnet-mounted front ramp proved the most effective, reducing total drag by nearly 30%. Additionally, a motorized flip-up taxi sign design demonstrated a remarkable 40% reduction in drag. Finally, a newly proposed taxi sign design, featuring longitudinal positioning and pointed triangular front and rear faces, resulted in a minimal 4.3% increase in vehicle drag compared to the baseline car.
Measuring Circularity and Impact Reduction Potential of Post-industrial and Post-consumer Recycled Plastics
Authors: Schulte Anna , Kampmann Benjamin , Galafton Christina
Published: July 2023

Post-industrial recycling (PIR) and post-consumer recycling (PCR) are measures to sustain re-sources by improving materials’ circularity and sustainability. Currently, circularity is mostly measured as the degree of reutilization of a material from 0 to 100 % at product or company lev-el. This lacks in assessing the resources’ usage over multiple product life cycles. Therefore, we propose to assess circularity as (i) the frequency resources are used in products (effective circu-larity eC) and (ii) a vehicle to reduce virgin resource use and environmental impacts (environ-mentally efficient circularity eeC). Besides, to compare the environmental impacts of using recy-cled materials from PIR or PCR, we analyse their impact reduction potential (IRP) indicating the environmental benefits of recycling in relation to virgin material put onto the market. We demonstrate the suggested indicators for a case study material: polypropylene. For this polymer type, the eC ranges between 0.93 and 9.08 uses of the resource on average depending on collec-tion, sorting, and recycling rates. Likewise, the eeC ranges between 0.31 and 1.50 uses per kg of CO2 equivalents emitted. PCR has a higher IRP regarding climate change impacts than PIR in all analysed scenarios. The results reveal the relevance of PCR and PIR beyond the product life cycle.
Incidence of Photosensitization in Husbandry Animals: A Meta Study on the Effects of Feed Diversity and Feed Choice
Authors: Aboling Sabine , Moritz Rieke
Published: July 2023

As most prominent plant-associated disease, photosensitization in large herbivores provides a substantial data base to evaluate the conditions under which animals are concerned. The purpose of this meta study was to investigate whether the level of feed plant diversity and feed choice influence the incidence of photosensitization. Case reports from 1900 to 2022 served as database. 113 publications described 178 cases of altogether 12 animal species, most of them being farm animals. 73.6% of the cases originated from three continents: South America, Australia and North-America. Of the 40 phototoxic agents, herbs represented the majority (63.6%). Brachiaria, Froelichia and other four genus were associated in almost 50% of the cases. Usually, animals received feed both of normal quality and in fresh state. Secondary photosensitization was most frequent only when associated with poor feed quality. If the animals had had access to high-diversity feed instead of low-diversity feed, the incidence was 27.5% smaller. If the animals had the choice between various kind of feed, the incidence was even reduced by 56.1%. Horses could select the least, however, suffered mainly from primary photosensitization. We conclude that farmers may prevent photosensitization in husbandry animals by allowing both more feed choice and feed diversity.
Using CMIP6 Models to Assess Future Climate Change Effects on Mine Sites in Kazakhstan
Authors: Golian Saeed , El-Idrysy Houcyne , Stambuk Desana
Published: July 2023

Climate change is a threat to mining and other industries, especially those involving water supply and management by inducing or amplifying some climatic parameters such as changes in precipitation regimes and temperature extremes. Using the latest NASA NEX-GDDP-CMIP6 datasets, this study quantifies the level of climate change that may affect the development of two mine sites (Site1 and Site2) in northeast Kazakhstan. The study analyses the daily precipitation and maximum and minimum temperature a of a number of global circulation models (GCM) over three future time periods, 2040s, 2060s and 2080s, under two shared socioeconomic pathway (SSP) scenarios, SSP245 and SSP585, against the baseline period 1981- 2014. The analyses revealed that: (1) Both maximum and minimum temperature will increase under both SSP in those time periods, with the rate of change for minimum temperature being higher than maximum temperature. (2) The mean annual precipitation will increase by an average rate of 7% and 10.5% in 2040s for SSP245 and 17.5% and 7.5% for SSP585 in 2080s at Site1 and Site2, respectively. It is also observed that summer months will experience drier condition whilst all other months will increase in precipitation. (3) The values of 24-hour precipitation with 10-year return period will also increase under both SSP scenarios and future time periods for most of the studied GCM and at both mine sites. These predicted changes should be considered as design criteria adjustments for project water supply and water management structures.
Use of Few-Layer Graphene Synthesized under Conditions of Self-Propagating High-Temperature Synthesis for Supercapacitors Applications
Authors: Vozniakovskii A.A. , Smirnova E.A. , Apraksin R.V. , Kidalov S.V. , Voznyakovskii A.P.
Published: July 2023

Graphene nanostructures (GNS) are among the most promising materials for creating supercapacitors. However, GNS are still not used in creating supercapacitors due to the impossibility of obtaining large volumes of high-quality material at an acceptable cost. In this work, we investigated the efficiency of using few-layer graphene (FLG) with the number of layers is not more than 5 synthesized under Self-propagating high-temperature synthesis (SHS) conditions as basic material for supercapacitors. Using the SHS process makes it possible to synthesize large volumes of FLG without Stone-Wales defects. It was found that the synthesized FLG makes it possible to obtain better results than using classical materials, namely activated carbon (AC). It was found that the sample based on FLG has a higher specific capacitance – 65 F×g-1 compared to the sample from AC, the specific capacitance of which is 35 F×g-1, for a speed of 5 mV×s-1 these values are 170 and 64 F×g-1, respectively. The drop in capacitance over 1000 cycles was 4%, which indicates a sufficiently high stability of FLG and allows us to consider FLG as perspective material for use in supercapacitors.
Alternatives for Transport, Storage in Port and Bunkering Systems for Off-Shore Green Hydrogen
Authors: Saborit Enrique , García-Rosales Eduardo , Gracia M. Dolores Storch de , Nieto Gema María Rodado , Fondón Pablo Martínez , Abánades Alberto
Published: July 2023

Offshore electricity production, mainly by wind turbines, and eventually floating PV in the future, will contribute to increase renewable energy production, as well as their dispatchability. The need for that energy evacuation and the implementation of the hydrogen economy are challenges that arise the evaluation of such energy facilities for the direct production of hydrogen. The analysis of the alternatives for the evacuation of offshore renewable electricity for the production of hydrogen is presented. The analysis includes discussion about the current state of the art of hydrogen pipelines and subsea cables, as well as the storage and bunkering system that is needed on shore. The main options for energy evacuation will be via an electric subsea cable to produce hydrogen onshore, or by pipeline, depending on the capacity of the offshore plant. For low capacity, an electric subsea cable is the best option. For high capacity renewable offshore plants, pipelines start to be competitive for distances above aprox. 450 miles.
Management of Cartilage-Conduction Hearing Aids in Pediatric Patients
Authors: Yakawa Satomi , Sugiuchi Tomoko , Myojin Rika , Murakami Takako , Sato Kiyoko , Miyoshi Yuki , Sugio Yuichiro
Published: July 2023

: Forty-nine children who started wearing cartilage conduction hearing aids (CC-HA) before elementary school graduation (including 17 cases of bilateral hearing loss and 32 cases of unilateral hearing loss) were followed up and examined. The wearing and utilization status of CC-HA, as well as the progress to date, were evaluated. In addition, 33 participants who purchased CC-Has were interviewed to assess the wearing effect. Eleven of the 17 children with bilateral hearing loss and 25 of the 32 children with unilateral hearing loss have continued using CC-HA. In terms of wearing effect, a good wearing effect was reported, even by those with one-sided hearing loss. In cases where it is difficult to wear CC-HAs stably with pasting or ear tips, it is possible to fix them stably using commercially available hair bands and eyeglass vines. In two cases, CC-HAs were worn from the age of 0. With ingenuity and appropriate educational and medical support, it is possible to wear CC-HA from infancy.
Polymerizationof alpha,omega-Bis(o-methoxyphenyl)arenes with trans-1,4-Cyclohexanedicarboxylic acid: Yielding Organosoluble Semi-Aromatic Polyketones
Authors: Maeyama Katsuya , Katada Ayumu
Published: July 2023

A series of alpha,omega-bis(o-methoxyphenyl)arenes were prepared through Suzuki-Miyaura coupling reactions of dibromoarenes with o-methoxyphenyl boronic acid. P2O5-CH3SO3H-mediated direct polycondensation of alpha,omega-bis(o-methoxyphenyl)arenes with trans-1,4-cyclohexanedicarboxylic acid proceeded regioselectively to afford 1,4-cyclohexanediyl-containing aromatic polyketones. The resulting aromatic polyketones have high Tg and excellent solubility in typical organic solvents. In addition, the polyketone films fabricated by solution casting method are more colorless and transparent than those without cyclohexanediyl units.
Begomovirus-Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA while Suppressing Host Defense Mechanisms
Authors: Breves Sâmera de S. , Silva Fredy A. , Euclydes Nívea C. , Saia Thainá F.F. , Jean-Baptiste James , Andrade Neto Eugenio R , Fontes Elizabeth P. B.
Published: July 2023

Begomoviruses, which belong to the Geminiviridae family, are intracellular parasites transmitted by whiteflies to dicotyledonous plants, significantly damaging agronomically relevant crops. These nucleus-replicating DNA viruses need to move intracellularly from the nucleus to the cytoplasm and then, like other plant viruses, spread systemically throughout the plant to cause dis-ease. The transport proteins of begomoviruses play a crucial role in recruiting host components for the movement of viral DNA within and between cells while exhibiting functions that suppress the host's immune defense. Pioneering studies on species of the Begomovirus genus have identified specific viral transport proteins involved in intracellular transport, cell-to-cell movement, and systemic spread. Recent research has primarily focused on viral movement proteins and their interaction with the cellular host transport machinery, significantly expanding our understanding of viral infection pathways. This review focuses on three main aspects: (i) the role of viral transport proteins, specifically movement proteins (MPs) and nuclear shuttle proteins (NSPs), (ii) their ability to recruit host factors for intra- and intercellular viral movement, and (iii) suppress antiviral immunity, with a particular emphasis on bipartite begomoviral movement proteins.
On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends
Authors: Alfaro Gómez Manuel , Fernández-Santos María del Rocío , Jurado-Campos Alejandro , Soria-Meneses Pedro Javier , Montoro Vidal , Soler Ana Josefa , Garde José Julián , Rodríguez-Robledo Virginia
Published: July 2023

Male infertility (MI) involves various endogenous and exogenous facts. These include oxidative stress (OS), which is known to alter several physiological pathways and it is estimated to be present at high levels in up to 80 % of infertile men. That is why since the late 20th Century, the relationship between OS and MI has been widely studied. New terms have emerged, such as Male Oxidative Stress Infertility (MOSI), which is proposed as a new category to define infertile men with high OS levels. Another important term is MOXI: Male, Antioxidants, and Infertility. Such term refers to the hypothesis that antioxidants could improve male fertility without the use of assisted reproductive technology. However, there is no evidence-based antioxidant treatments that directly improve seminal parameters or birth ratio. In this regard, there is controversy about their use. While certain scientists argue against their use due to the lack of results, others support this use because of their safety profile and low price. Some uncertainties related to the use of antioxidants for treating MI are their questionable efficacy or the difficulties to know their correct dosage. In addition, the lack of quality methods for OS detection can lead to an excessive antioxidant supplementation, resulting in “reductive stress”. Another important problem is that, although the inflammatory process is interdependent and closely linked to OS, it is usually ignored. To solve these uncertainties, new trends have recently emerged. These include the use of molecules with anti-inflammatory and antioxidant potential, and which are also able to specifically target the reproductive tissue; as well as the use of new methods that allow for reliable quantification of OS and a quality diagnosis. This review aims to elucidate the main uncertainties about MOXI and to outline the latest trends in research to achieve effective therapies with clinically relevant outcomes.
STRATEGI MINDFULL PARENTING PADA DUAL CAREERS FAMILY
Authors: Ranita Sari  , Hasanah Uswatun , Hasanah Uswatun , Nugraheni Prastiti Laras
Published: July 2023

Penelitian ini merupakan penelitian deskriptif mengenai strategi mindful parenting pada dual careers family yang bertujuan untuk mendeskripsikan hasil survei kuesioner. Metode penelitian ini yang digunakan yakni metode deskriptif kuantitatif. Responden dalam penelitian ini merupakan dual careers family. Responden dalam penelitian ini berjumlah 93 orang. Hasil penelitian yang diperoleh menunjukkan bahwa variabel mindful parenting yang diterapkan oleh dual careers family dalam penelitian ini dikategorikan tinggi dengan presentase 53% (49 orang). Dual Careers Family yang dikategorikan tinggi dalam dimensi Being In The Moment with The Child sebesar 57%. Sedangkan, Dual Careers Family yang dikategorikan tinggi dalam dimensi Mindful Dicipline sebesar 49%.
Evaluation of Racial, Ethnic, and Socioeconomic Disparities in Indication for Carpal Tunnel Release
Authors: Kerluku Jona , Walker Paul , Amen Troy , Almeida Bryan Aristega , McColgan Rosie , Urruela Adriana , Nguyen Joseph , Fufa Duretti T.
Published: July 2023

Background:

Disparities in the utilization of orthopaedic surgery based on race and ethnicity continue to be reported. We examined the impact of sociodemographic factors on treatment recommendation by hand surgeons for carpal tunnel syndrome (CTS) of similar disease severity.

Methods:

Patients with electrodiagnostic study (EDS)-confirmed CTS were evaluated at a single institution between 2016 and 2020. Data including patient age, sex, race/ethnicity, ZIP Code, and EDS severity were collected. The primary outcome was the recommended treatment by the hand surgeon at the first clinic visit according to patient race/ethnicity and the Social Deprivation Index (SDI). Secondary outcomes included the treatment selected by patients (nonsurgical or surgical) and the time to surgery.

Results:

The 949 patients had a mean age of 58 years (range, 18 to 80 years); 60.5% (n = 574) were women. The race/ethnicity of the patient cohort was 9.8% (n = 93) Black non-Hispanic, 11.2% (n = 106) Hispanic/Latino, 70.3% (n = 667) White non-Hispanic, and 8.7% (n = 83) “other.” Overall, Black non-Hispanic patients (38.7%; odds ratio, [OR] 0.62; 95% confidence interval [CI], 0.40 to 0.96) and Hispanic/Latino patients (35.8%; OR, 0.55; 95% CI, 0.36 to 0.84) were less likely to have surgery recommended at their first visit compared with White non-Hispanic patients (50.5%). This was no longer apparent after adjusting for demographic and clinical variables including EDS severity and SDI (Black non-Hispanic patients: adjusted odds ratio [aOR], 0.67; 95% CI, 0.4 to 1.11; Hispanic/Latino patients: aOR, 0.69: 95% CI, 0.41 to 1.14). Across all categories of EDS severity, surgeons were less likely to recommend surgery to patients with a higher SDI (aOR: 0.66, 0.64, and 0.54 for quintiles 2, 3 and 4, respectively). When surgery was recommended, patients in the highest SDI quintile were less likely to proceed with surgery (p = 0.032). There was no association between patient race/ethnicity and the treatment selected by the patient or time to surgery (p = 0.303 and p = 0.725, respectively).

Conclusions:

Patients experiencing higher levels of social deprivation were less likely to be recommended for CTS surgery and were less likely to proceed with surgery, regardless of patient race/ethnicity. Additional investigation into the social factors influencing both surgeon and patient selection of treatment for CTS, including the impact of patient socioeconomic background, is warranted.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
PENGARUH PENAMBAHAN LIMBAH BATU BATA MERAH BUKITTINGGI SEBAGAI FILLER PADA CAMPURAN AC-WC DENGAN PENGUJIAN MARSHALL
Authors: Misbah Misbah , Pratiwi JF Anggun , Arman Arman , Mulyati Mulyati , Rofifah Jihan
Published: July 2023

Keberadaaan jalan raya sangat dibutuhkan dalam pengembangan suatu daerah. Permasalahan yang sering dihadapi dalam pembangunan jalan raya yakni muatan kendaraan berlebih dari yang diizinkan, pemeliharaan jalan yang kurang optimal serta pengaruh faktor campuran aspal, sehingga sering ditemukan jalan mengalami kerusakan sebelum umur rencana tercapai. Untuk meningkatkan kualitas konstruksi perkerasan jalan perlu dilakukan penelitian terhadap inovasi campuran yang digunakan atau memberikan bahan tambahan lain pada campuran konstruksi perkerasan tersebut, sehingga dihasilkan mutu campuran yang lebih baik. Jenis penelitian yang bisa dilakukan salah satunya adalah menggunakan metoda pembuatan benda uji dengan melakukan percobaan dilaboratorium dengan menganalisa pengaruh penambahan limbah batu bata merah Bukittinggi  sebagai filler pada campuran AC-WC dengan pengujian Marshall. Dari hasil penelitian dengan pengujian Marshall yang telah dilakukan, dengan judul “Pengaruh Penambahan Limbah Batu Bata Merah Bukittinggi  sebagai Filler pada campuran AC-WC dengan pengujian Marshall, didapat hasil pada penambahan variasi 1% filler limbah batu bata merah mengakibatkan nilai properties yaitu nilai : stabilitas, MQ, VMA, VFA memenuhi persyaratan spesifikasi Bina Marga 2018 revisi 2, sedangkan pada penambahan variasi 2% filler limbah batu bata merah mengakibatkan nilai properties yaitu nilai Flow dan VIM tidak memenuhi persyaratan spesifikasi Bina Marga 2018 rmevisi 2, hal ini menandakan meningkatnya deformasi pada lapis perkerasan saat diberikan beban. Maka, pada variasi penambahan 2% tidak dianjurkan, penggunaan limbah batu bata merah sebagai filler added pada campuran AC-WC yang dapat digunakan hanya sampai batas 1%.
Biogeography and Species Durations of Selected Cenozoic Shallow and Deep-Water Smaller Calcareous Benthic Foraminifera – A Review
Authors: Hayward Bruce W. , Holzmann Maria
Published: July 2023

Most previous accounts summarising the biogeography and species durations of smaller calcareous benthic foraminifera have been based on literature reviews or on a massive North American database that had been taxonomically standardised. In this review we limit consideration to extant and fossil families or genera (from nearshore, open shelf, and deep-sea environments) with modern reviews that have standardised their global morphotaxonomy and where available, are complimented by molecular studies.

We confirm previous studies that indicate most shelf species have limited geographic ranges and the majority of deep-water species are widespread and cosmopolitan or nearly so. In our intertidal and inner shelf groups only one species (molecular and morphological), Ammonia veneta, has a cosmopolitan distribution, although four warm-water morphospecies, of Ammonia and Rugobolivinella, have or had distributions that spanned more than one ocean in equatorial latitudes. The majority of both warm- and cool-water species in these groups are regionally or locally-restricted endemics (92% of Bolivinellidae, 100% of Tubulogenerina, 73% of Ammoniidae). The biogeographic distribution of the two rarer, warm-water groups (Bolivinellidae, Tubulogenerina) changed dramatically through the Cenozoic with the Paleocene–Eocene North American–European distribution of Bolivinellidae switching to purely Indo-Pacific by the Pliocene–Quaternary.

In our shelf–upper bathyal groups (Notorotaliiidae, Plectofrondiculariidae), two genera have been restricted to the Southern Hemisphere since their Eocene originations with their greatest diversity throughout in New Zealand and Australia, respectively. The dominantly cold-water notorotaliid genus Buccella has a biogeographic distribution largely restricted to the Arctic Ocean and both coasts of North and South America. Most notorotaliid species are locally or regionally endemic (100% of Notorotalia, Parrellina, Porosorotalia, 75% of Buccella). At least 50–60% of species in five extinct mid-bathyal–abyssal families are cosmopolitan and have been throughout the Cenozoic since their originations. The majority of these deep-sea species with more-restricted distributions are rare, and many could possibly be more widespread with further extensive study.

This review found that the shortest mean species durations (4–5 myrs) occur in two groups of rather rare, tropical–subtropical inner-shelf foraminifera with many locally endemic species. In cooler and progressively deeper water environments the mean species durations increase to 7–11 myrs for temperate shelf–bathyal taxa (Notorotaliidae), 20 myrs for an extinct mid-shelf to bathyal family (Plectofrondiculariidae) and 41–50 myrs for five extinct mid-bathyal–abyssal families (Chrysalogoniidae, Ellipsoidinidae, Glandulonodosariidae, Pleurostomellidae, Stilostomellidae). One species in each of four of these deep-water families had a species duration of 150–120 myrs.
Distinguishing Coastal Habitats of Caribbean Panama with Benthic Foraminifera
Authors: Gudnitz Maria N. , Collins Laurel S.
Published: July 2023

Benthic foraminifera were collected from reef coral, seagrass and mangrove sediments of Almirante Bay, Caribbean Panama, to associate species and assemblages with habitats and environmental conditions related to degraded water quality. The three habitats occur in different adjacent areas within an embayed, patch-reef setting. We analyzed the relative abundance, diversity and community structure of benthic foraminiferal species > 63 µm in 17 sediment samples from < 2 m mean water depth. Results from hierarchical cluster analysis, analysis of similarity, similarity percentages, non-metric multidimensional scaling and Fisher's alpha diversity were compared from seagrass, mangrove and coral habitats and also between two areas with contrasting water quality as previously defined by hydrography and general water quality.

Among the three neighboring habitats, assemblages are fairly similar but differ in species proportions. Overall, Ammonia parkinsoniana, indicative of relatively low and variable salinities, is a dominant taxon. Foraminiferal assemblages from mangroves had the lowest mean diversity, a common trend under reduced salinity conditions, and diversity appears to be regionally controlled by freshwater input. Planorbulina acervalis was dominant in seagrass beds. Low-diversity, stress-tolerant foraminiferal assemblages are present in samples from all three habitats, reflecting the bay's highly variable patch-reef structure, freshwater input, and possible hypoxia. Diversity is generally lower near the mainland than in the eastern bay off the island of Isla Colón. Environmental associations of the benthic foraminifera of Almirante Bay are baseline ecologic data for comparisons to coastal habitats formed before human occupation and have the potential to be used in the sedimentary record to assess the impact of anthropogenic disturbance.
Study on the impact of decarbonization on regional coal-fired power generation -based on mechanism analysis and empirical tests
Authors: Tan Caixia , Geng Shiping , Tan Qingbo , Tan Zhongfu , Wang He
Published: July 2023

The impact of decarbonization on regional coal-fired power generation is investigated using a weighted control method with panel data for China from 2001 to 2020. Five provinces, Guangdong Province, Liaoning Province, Hubei Province, Shaanxi Province and Yunnan Province, were used as the experimental group, and the remaining provinces were used as the control group. The robustness of the experimental results was verified by multidimensional tests such as dynamic test, counterfactual test, change window period test and ranking test. The empirical test results show that the low-carbon policy has a restraining effect on the carbon emissions, coal consumption and coal-fired power generation caused by regional coal-fired power generation. At the same time, Hansen test results show that low-carbon policy has no significant impact on regional coal-fired power generation through technology effect, but it has significant impact on regional coal-fired power generation through structure effect and regulation effect.
The role of overfeeding in infants with brief resolved unexplained events (BRUE): a prospective observational study
Authors: Quitadamo Paolo , Mosca Caterina , Verde Alessandra , De Marco Giulio , Giorgio Valentina , Valitutti Francesco , Dolce Pasquale , Parisi Pasquale , Evangelisti Melania , Andreozzi Marialuisa , Nardo Giovanni Di
Published: July 2023

Background
Although inappropriate feeding has been suggested to play a role in the occurrence of BRUE, only anecdotal reports have been so far described. The main objective of our study was to objectively evaluate whether overfeeding may represent a risk factor for the occurrence of BRUE.
Methods
We enrolled 42 infants aged 0–6 months admitted for BRUE episodes and a same number of age- and sex-matched healthy infants, who served as controls. Data about feeding practices and auxological parameters of each enrolled infant were collected and analysed, along with clinical data about peri- and post-natal period. Main outcome measures were mean daily body weight gain, daily number of feedings and mean volume of feedings and average daily volume of feedings only for bottle-fed infants.
Results
The mean (± SD) daily body weight gain, the only available and reliable parameter to assess feeding adequacy in both breast- and formula fed infants, was 41 ± 15 grams in infants with BRUE vs 35 ± 11 grams in healthy infants (95% CI [0.21; 11.8], p = 0.042). Moreover, infants with BRUE were more likely than controls having received mixed breastfeeding, although this difference did not reach statistical significance (33% vs 17%, 95 CI [-0.04; 0.37], p = 0.131).
Conclusions
Overfeeding seems to be a risk factor for the occurrence of BRUE, either through milk inhalation and choking or through GER worsening. Detecting inappropriate feeding practices, and providing appropriate education to correct them, may help preventing the occurrence of BRUE produced by either scenarios.
The impact of climate change on habitat of a vulnerable European Otter (Lutra lutra) in Iran
Authors: Nazari Zahra , Khalilipour Olyagholi , Ashrafzadeh Mohammad Reza , Saidian Soheil
Published: July 2023

Climate change's effect on plants and animal species is one of the significant concerns of conservation biologists. These changes cause an increase in extinction and changes in the distribution and abundance of species. This research examined the impact of climate change on the habitat of the European Otter (Lutra lutra) in Khuzestan based on habitat modeling in R with climate scenarios and general circulation model MRI-ESM2-0. For this purpose, more than 40 presence points were recorded and 10 climatic and environmental variables were used as input for species distribution models including the Generalized Linear Model (GLM), Generalized Boosting Method (GBM), random forest (RF), and Multivariate Adaptive Regression Splines (MARS). The value of AUC and TSS and the Kappa coefficient indicate the high accuracy and precision of the model. The RF and GBM are the best methods to determine the habitat of the European Otter in Khuzestan. The variables of distance from the river, Annual Mean Temperature (Bio), and Isothermality index had the greatest role in habitat suitability. The 185.9176 Km2 (14.3%) of Khuzestan was identified as a suitable habitat for this species. The prediction of changes in the geographical distribution of the species under the climate scenarios of ssp126, ssp370, and ssp585 showed that the habitat of this species would decrease by 10.37, 10.38 and 11.58%, respectively. According to the results of climate change, it has a significant impact on the distribution range of the species.
pH-dependent effects of polystyrene microplastics on ciprofloxacin toxicity and uptake by ryegrass
Authors: Wang Yun , Shan Ning , Habibul Zumrat , Habibul Nuzahat
Published: July 2023

The ubiquitous coexistence of microplastics (MPs) and antibiotics in the aquatic environment has been demonstrated, and as such, the effects of environmental conditions (such as pH) on combined toxicity of MPs and antibiotics to biota must be determined. Here, we investigated the effects of different pH on combined toxicity of polystyrene MPs- ciprofloxacin (CIP) to ryegrass growth and uptake of CIP by ryegrass. The results revealed that, regardless of with or without MPs, the neutral and basic condition decreased CIP accumulation in ryegrass roots. However, CIP contents in shoots (including leaves) increased with increasing solution pH. Relative to pH 5.3, CIP contents in shoots increase of 24.7-fold and 29.5-fold with CIP+200 nm MPs and CIP+500 nm MPs treatment at pH 8.8. Moreover, the effects of pH on root and shoot growth inhibition more obvious at pH 7.0 and pH 8.8 than at pH 5.3. Under the neutral and basic condition (pH 7.0 and pH 8.8), the ryegrass shoot length of 500 nm MPs+CIP and 200 nm MPs+CIP treatment was only 50.3%, 69.7% and 86.8%, 81.3% of the acidic condition (pH 5.3) plants, respectively. These findings implied that the uptake and toxicity of CIP with MPs in ryegrass were influenced by solution pH. Furthermore, the relatively higher CIP removal efficiency imply the potential for CIP removal by ryegrass under MPs co-contaminated environment.