bluuebunny/crossref_metadata_2025 huggingface dataset:
Facilitation of interspecies electron transfer in anaerobic processes through pine needle biochar
Authors: Mohan Chander , Annachhatre Ajit
Published: October 2022

Role of biochar in promoting methanogenesis during anaerobic processes was investigated in this research. Biochar produced from Himalayan pine needles was used as medium for conductive material mediated interspecies electron transfer (CM-IET) amongst the electron producing microorganisms and electron consuming methanogenic archaea. Three anaerobic continuous stirrer tank reactors (CSTRs) with 0, 5 and 10 g/L pine needle biochar (PNB) were operated at steady state organic loading rate (OLR) of 2.0–2.5 kgCOD/(m3.d). R0 (0 g/L PNB), representing indirect interspecies electron transfer (IIET), failed at an OLR of 2.0 kgCOD/(m3.d) due to the highest volatile fatty acid (VFA) concentration of 6,300 mg/L among the three CSTRs. On the other hand, at an OLR of 2.5 kgCOD/(m3.d), R2 (10 g/L PNB) showed the most superior performance with chemical oxygen demand (COD) removal of 55% and volatile fatty acid (VFA) concentration of 3,500 mg/L, while R1 (5 g/L PNB) recorded COD removal of 45% and VFA concentration of 4,400 mg/L. In comparison, fixed biofilm reactor (FBR) with 80 g/L of PNB as support material operated satisfactorily at OLR of 13.8 kgCOD/(m3.d) with 70% COD removal and VFA concentration of 1,400 mg/L. These investigations confirmed the beneficial role of biochar in anaerobic processes by promoting CM-IET amongst VFA degrading bacteria and methane producing archaea.
Improved nitrogen removal efficiency by implementation of intermittent aeration
Authors: Srb M. , Lánský M. , Charvátová L. , Koubová J. , Pecl R. , Sýkora P. , Rosický J.
Published: October 2022

The aim of the paper was to verify the possibility of using intermittent aeration to decrease outflow total nitrogen concentrations in municipal WWTPs of different capacities (15,780, 23,000 and 806,250 PE). A simple time-based intermittent aeration control was used in the experimental work. The results of WWTPs are compared with each other and with literature sources. The use of intermittent aeration led to a significant decrease of outflow total nitrogen concentration by up to 57% without the need of additional investment costs or the increase of operating costs. Nitrification kinetic tests and fluorescence in-situ hybridization observations proved that intermittent aeration has no negative impact on nitrifiers. The results proved that it is possible to utilize intermittent aeration for treatment plants initially designed with permanent aeration of nitrification sections if the current load is lower than the designed capacity. A necessary prerequisite for successful implementation of intermittent aeration is sufficient blower power. Although the time-based control is very simple and inexpensive to implement, the results are comparable to more complex systems such as systems based on rule-based systems for N-NH4+ and N-NO3− concentrations, on fuzzy logic or on mathematical models.
High Density Lipoprotein: Are Elevated Levels Desirable and Achievable?
Authors: Bisgaier Charles L. , Pape Michael E.
Published: October 2022

In this review we focus on addressing two questions concerning high density lipoproteins (HDL). First, are elevated levels of HDL a desirable clinical plasma endpoint .>?: and secondly, if so, can strategies be devised that would allow the identification of agents •.• ef
to elevate HDL. To address the first question we briefly review the human epidemiologic ,., .._,,; • "'.
and prospective data that identifies HDL as a risk factor for coronary heart disease (CHD). •• ....
To introduce HDL elevating strategies, we next provide a brief review of the structural and enzymatic features of HDL followed by a discussion on the current thinking of the metabolic origin of the lipoprotein. We then turn to discussions on the key plasma and cell associated proteins involved in the synthesis, catabolism, and remodeling of HDL by analyzing data derived from human mutations, genetically engineered animal models with altered HDL metabolism and in vitro experimental systems. Lastly, we propose approaches to raise HDL that are either based on identification of small organic molecules or more unconventional approaches such as gene therapy or delivery of biologicals into plasma. This last section is based on an evaluation of the putative mechanism of actions of both old and new HDL elevating compounds. Our review concludes with an optimistic view that agents can be identified which may have promise in the treatment of human hypoalphalipoproteinemia andCHD.
Recent Developments in Tetracycline Antibiotics
Authors: Sum P.E. , Sum F.W. , Projan S.J.
Published: October 2022

The rapid emergence of pathogenic bacteria resistant to tetracyclines and other currently available antibiotics has caused serious concern among medical professionals. It has heightened resurgent interest in studying the mechanisms of resistance and in developing new antibiotics. A comprehensive review has outlined the developments of tetracyclines prior to 1980 (47]. This review will highlight the pertinent advances in the tetracycline field during the last two decades, including recent progress on elucidating the mechanisms of resistance, and the development of novel tet­
racyclines to combat bacterial resistance. Most of the new tetracycline derivatives described in this review have been either prepared semisynthetically or isolated from entation. In the semisynthetic area, efflux inhibitors that are effective in an in vitro model have been identified. A new class of tetracyclines, named glycylcyclines has been the subject of numerous reports, and will be the major focus of this review. The glycylcyclines are currently the only derivatives that exhibit antibacterial activity comparable to that of the early tetracyclines when they were first introduced. These compounds show potent activity against a broad spectrum of Gram-positive and Gram-negative bacteria, including strains that carry the two major tetracycline­ resistance determinants, efflux and ribosomal protection. Two of the glycylcycline derivatives, DMG-MINO and DMG-DMDOT, have been studied by several groups of investigators against a large number of clinical pathogens isolated from various sources. The spectrum of activity of these compounds includes organisms with resistance to antibiotics other than tetracyclines, e.g., methicillin-resistant staphylococci, penicillin-resistant streptococcus pneumoniae, and vancomycin-resistant enterococci. Their in vitro, as well as in vivo activity against bacteria with characterized tetracycline- or minocycline-resistant elements will be summarized. The structure-activity relationships of glycylcyclines and their mode of action will also be discussed.
A Redox Pathway Leading to the Alkylation of Nucleic Acids by Doxorubicin and Related Anthracyclines: Application to the Design of Antitumor Drugs for Resistant Cancer
Authors: Kocht Tad H. , Taatjes Dylan J. , Fenick David J. , Gaudianot Giorgio
Published: October 2022

Doxorubicin has been a constituent of antitumor drug protocols for a broad spectrum of cancers for more than two decades. Side effects and resistance continue to be important limitations. Drug targets responsible for both side effects and anti-tumor activity are cell membrane receptors, cell membrane lipids, nucleic acids and topoiso-
merase. Induction of oxidative stress is responsible for most if not all biological activity. An important consequence of oxidative stress is the production of formaldehyde which can subsequently be utilized by the drug for covalent bonding to nucleic acids and other targets as shown by in vitro experiments. Multidrug resistance mechanisms inhibit drug-induced DNA damage, drug uptake, and drug-induced oxidative stress. Synthetic anthracyclines conjugated to formaldehyde circumvent some if not all of the resistance mechanisms. Consequently, anthracycline-formaldehyde conjugates have potential for the treatment of resistant cancer.
Recent Progress in the Development of Tubulin Inhibitors As Antimitotic Antitumor Agents
Authors: Lee Kuo-Hsiung , Shi Qian , Chen Ke , Morris-Natschke Susan L.
Published: October 2022

Tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. Hundreds of synthetic or semisynthetic tubulin inhibitors have been discovered and developed recently that are related to the natural products colchicine, vinblastine; and taxol. Representatives include allothiocolchicinoids, vinorelbine, and taxotere. This review will describe the recent progress being made in the development of novel antimitotic antitumor tubulin inhibitors. The emphasis has been placed on related research in the author's laboratory, including development of colchicine derivatives and
other colchicine binding site drugs, such as flavonoids and quinolone derivatives. Syntheses and modifications of novel compounds, biological activity evaluation, and structural activity relationships will be discussed as well. Further research will undoubtedly lead to the discovery of additional tubulin inhibitors that have potential for use as anticancer drugs.
Heterocyclic Analogs of DNA Minor Groove Alkylating Agents
Authors: Baraldi P.G. , Cacciari B. , Guiotto A. , Romagnoli R. , Zaid A.N. , Spalluto G.
Published: October 2022

It is generally accepted that neoplastic transformation is related to genes alteration or oncogene activation. In particular, DNA minor groove binding drugs have been extensively studied through the years in order to influence the regulation of gene expression by means of specific interactions with DNA bases moieties. Pyrrolo[2,l­ c].[l,4].benzodiazepines (PBDs), CC-1065 and distamycins are three classes of minor groove binders which showed interesting cytotoxicity profiles, refined through already reviewed processes of SAR studies.
Among the modifications to the three families of antitumor compounds, heterocyclic substitutions have been extensively applied by many groups in order to either modify the reactivity profile or introduce extra interactions within the minor groove, thus changing the binding site or modulating the binding sequence. The updated material related to these modifications has been rationalised and ordered in order to offer an overview of the argument.
DR (MHC Class 11) Ligands: an Approach to Rheumatoid Arthritis Therapeutics
Authors: Hanson Gunnar J.
Published: October 2022

The presentation of peptide antigens to T-cells by MHC Class II proteins is a central process in cellular and humoral immune responses. Blockade of this presentation event via synthetic ligands that bind to disease-associated MHCs (such as DR1 and DR4 l may be useful for the treatment of autoimmune diseases such as rheumatoid arthritis, Type I diabetes, multiple sclerosis, lupus erthymatosis and Graves disease. Recently reported synthetic ligands for DR1 and DR4 are short modified peptides (2-7mers) capable of competing at nanomolar concentrations with antigenic peptides for the DR (MHC) binding groove.
Circular External Fixation for Distal Femoral Physeal Injury: A Case Report
Authors: Sato Takahiro , Chida Shuichi , Nozaka Koji , Kobayashi Moto , Sakuraba Tsutomu , Sasaki Ken , Miyakoshi Naohisa
Published: October 2022

Background:

Distal femoral physeal injuries are a challenging clinical scenario because the injuries have a high risk of growth disturbance. The selected treatments include closed reduction and cast immobilization, percutaneous pin fixation, and cannulated screws or internal fixation, but these treatments have some complications. Circular external fixation enables rigid immobilization and walking with full weight bearing. To the best of our knowledge, there is no article on the results of using circular external fixation for distal femoral physeal injury. This case is the first in which circular external fixation for distal femoral physeal injury is used.

Case Presentation:

A 9-year-old boy was injured in a skiing accident, and his injury was a Salter-Harris type II fracture of the distal femoral epiphysis. We immediately performed percutaneous pin fixation with circular external fixation under general anesthesia. After surgery, he was allowed to walk with full weight bearing. One year after surgery, he had no pain, and his knee regained full extension and 140°flexion.

Conclusion:

We consider circular external fixation to be an effective treatment option because of its rigid immobilization without injury to the plate. However, we and patients must fully acknowledge its difficulties (i.e., pin-site problems, neurologic injury, vascular injury, joint stiffness, and pain, and difficulty sleeping).
Implementation of Electronic Health Record System in Ghana: A Review
Authors: Achampong Emmanuel Kusi
Published: October 2022

There are several pieces of evidence to prove that electronic health records (EHRs) can improve the quality of service, efficiency, safety, and positive patient outcomes. Past decades have seen rapid growth in EHR system implementation in healthcare institutions in developing countries. Effective implementation of EHR system provides a unique opportunity to collect a wide range of patient data to support health tracking over a time period. This study seeks to make a case as to why despite some EHR system implementations in Ghana, there has not been any significant improvement in patient outcomes. This research is not a systematic review but assesses the implementation challenges of EHRs in Ghana. Several papers were identified by searching through some databases, including Google Scholar, PubMed, and Medline, using the following topics: EHR implementation, EHR implementation challenges, and EHR system implementation and EHR challenges in Ghana. The approach to the implementation of EHR system largely depends on the country dynamics and does not necessarily follow top-down or bottom-up methods. The focus should also be on the institution and whether they have the resources to make the project implementation successful. End-users should be an integral part of the whole implementation process, and their recommendations should be followed and implemented.
Analyzing the Adoption of Clean and Healthy Living Behaviors against COVID-19 Students in Indonesia
Authors: Utami Tri Niswati , Usiono Usiono , Sayekti Retno
Published: October 2022

The ease of obtaining information influences students adopting the behavior.

Purpose:

To analyze the indicators of clean and healthy living behavior (PHBS) on students and find the effect of information in dealing with COVID-19.

Methods:

This is a quantitative study using a cross-sectional design and was conducted from March – to June 2020. The sample of students at one of the State Universities in Medan City was 352 respondents. Furthermore, the data were collected through a questionnaire, and path analysis determined the relationship between variables x and y. The influence of the respondents’ characteristic variables (X1) on the consumption of nutritious food (Y1), exercise habits (Y2), handwashing habits (Y3), environmental hygiene (Y4), smoking habits (Y5), wearing masks (Y6), water consumption (Y7), consumption of cooked food (Y8), use of health facilities (Y9), the habit of praying (Y10) was analyzed. Meanwhile, the effect of access to information (X2) on the consumption of nutritious food (Y1), exercise habits (Y2), handwashing habits (Y3), environmental hygiene (Y4), smoking habits (Y5), wearing masks (Y6), water consumption (Y7), consumption of cooked food (Y8), use of health facilities (Y9), and praying habit (Y10) was studied.

Results:

This study found that information affected the consumption of nutritious food, exercise habits, handwashing habits, and health facilities with a T-statistic value of 2.603, 1.970, 2.941, and 4.631, respectively, while individual characteristics influenced the use of masks with a value of 2,167.

Conclusion:

Information affects PHBS, and information media is an effective way and impetus for students to adopt the behavior. Furthermore, behavior change will be impacted when information is presented well.
Diagnostic techniques for infectious bovine rhinotracheitis: a review
Authors: Dima Chala , Abdisa Kebede
Published: October 2022

Infectious bovine rhinotracheitis (IBR) is a group of the bovine respiratory disease multifaceted pathogens and a key disease of cattle, leading to significant economic losses to the dairy industry globally. The causative agent of IBR is Bovine herpesvirus type-1 (BoHV-1), which is a member of the genus Varicellovirus in the Alphaherpesvirinae subfamily, which belongs to the family Herpesviridae, order Herpesvirales. BoHV-1 can be categorized into three subtypes (BoHV-1.1, BoHV-1.2a, and BoHV-1.2b) that belong to one single viral species, which is a serologically indistinguishable strain. Therefore, a more optimal method for the rapid diagnosis of BoHV-1 infection is highly needed. Hence, the objective of this paper is to review the appropriate diagnostic techniques for the IBR virus in infected cattle. In this review, various rapid and confirmatory diagnostic methods used for the diagnosis of BoHV-1 infection were briefly described. BoHV-1 can be routinely detected by virus neutralization tests and enzyme-linked immunosorbent assays (indirect or blocking ELISA). IBRgE-ELISA is the most specific serological test for BoHV-1 and is recommended for marker vaccine to differentiate wild infection from vaccination schemes. Furthermore, virus isolation from tissue or swab samples by cell culture and DNA detection with LAMP, PCR, and real-time PCR techniques are all used to detect infected cattle. Direct sequencing of the entire genome using the Sanger sequencing method recently allowed for the differentiation of BoHV-1 subspecies and the distinction of the BoHV-1 field strain from vaccine strains based on single nucleotide polymorphisms. As the gold standard diagnosis for IBR is virus isolation in cell culture, commonly followed by BoHV-1 gene sequencing, it is also recommended.
The Role of Agriculture in the Australian Government’s Emission Reduction Fund
Authors: White Robert
Published: October 2022

Australia’s greenhouse gas emissions from agriculture in 2022 were 67.8 million (M) tonnes (t) of carbon dioxide equivalent (CO2-e), amounting to 12.9% of total emissions. Erupted methane (CH4) from ruminant animals comprised 42% of agricultural emissions. By 2030, the Australian Government aims to reduce total emissions by 43% from the 2005 level. The primary policy instrument for achieving this reduction is the Emissions Reduction Fund (ERF) in which there are two main pathways for agriculture – emission avoidance through suppression of CH4 emissions and soil carbon sequestration (SCS) through approved projects. Although agriculture since 2014 has promised 15.2 Mt of abatement, by April 2022 it has delivered only 1.1 Mt. Examples are given of potential abatement by SCS for pasture and cropping land in different rainfall zones. Methods of suppressing CH4 emissions have yet to be scaled up commercially and proven for grazing animals. The main constraints on SCS are the unreliability of Australian rainfall, the high cost of project management relative to the value of a C credit, and the opportunity cost of maintaining an approved land management for at least 25 years.
SPATIAL ABILITY IN MEDICAL AND DENTAL EDUCATION: SCOPING REVIEW
Authors: Ramadhani Nabilla Riadi Nur , Firman Dani Rizali , Sarilita Erli , Lita Yurika Ambar
Published: October 2022

Background: the ability to mentally manipulate 3D objects and understanding the relationships between structures is essential in many fields of medical and dental specialties. This scoping review of the literature on spatial ability in medical and dental education was conducted to provide a map of the literature and identify where gaps still exist for future research.Methods: the study was conducted using a scoping review method with guidelines from the Arksey and O'Malley framework to identify literatures related to the research topic. Searches was performed from February to May 2021 in PubMed, Cochrane, CINAHL and Google Scholar using keywords related to spatial ability, medical education and dental education. Literatures was also identified using snowballing technique. PRISMA-ScR analysis for study selection was performed.Results: fifteen articles were selected for review. Spatial ability correlates with performance in studying anatomical knowledge of medicine and dentistry, and surgery. 3D anatomical models are more effective when conveying complex spatial relationships than traditional 2D models. The Mental Rotation Test (MRT) is the most widely used test for measuring spatial abilities. The results of the measurement of spatial ability showed the superiority of males over females.Conclusion: spatial ability and learning in medical and dental education provide mutual benefits for both aspects. Additional spatial abilities module may be added to medical and dental education curricula to improve learning success
CRITICAL THINKING, CLINICAL REASONING SKILLS AND COGNITIVE ABILITIES OF DENTAL STUDENTS
Authors: Chrismawaty Bernadetta Esti , Emilia Ova , Rahayu Gandes Retno , Ana Ika Dewi
Published: October 2022

Background: Critical thinking (CT) and clinical reasoning (CR), along with adequate clinical knowledge, are crucial components of thinking in clinical practice. This study aimed to assess, compare and analyze the relationship between CT skills, CR skills, and cognitive abilities in undergraduate (UDS) and clinical dental students (CDS).Methods: This natural experimental study was conducted using the quantitative descriptive-analytic methods with a cross-sectional design. Thirty UDS and sixty-one CDS were selected purposively. Demographic and academic data were obtained through questionnaires. The Critical Thinking Tool (CriTT) was used to measure CT skills, and CR skills were measured by the Diagnostic Thinking Inventory (DTI). Knowledge acquisition was measured through the Cognitive Ability Test (CAT), which is a set of multiple-choice questions specifically developed and validated for this study. The statistical differences between them were analyzed by one-way ANOVA, and their relationship was tested by correlation matrix analyses.Results: There were no differences in CriTT measurements between groups. The overall DTI score and subscale 2 (Structure of memory) showed significant differences between groups, as did the overall CAT score and all clinical science subscales. Correlation matrix analyses revealed CR skills were related to CT skills, while the cognitive abilities or knowledge acquisition were related to CR skills.Conclusion: Results showed the CR skills and cognitive abilities of clinical dental students are superior to undergraduate dental students. Generally, the results indicated the more skilled students are in critical thinking, the better are their clinical reasoning skills. Better cognitive abilities tended to improve clinical reasoning skills.
Acquisition of Genitive Case by Bilingual Guilaki-Persian English Learners
Authors: Biderooni Maryam Tahvildary , Jabbari Ali Akbar , Nasiriani Yasaman
Published: October 2022

The present study focuses on recognition and production of the English genitive cases with similar structure in Guilaki (i.e., possessive determiners and possessive relations) or Persian (i.e., non-possessive relations) at initial state of EFL acquisition. In this regard, the researcher selected the most proficient Guilaki and Persian speakers-beginner EFL learners who were comparably aware of the structures under study to establish L3 and L2 groups. Both groups equally comprised 30 female third-grade junior high school English learners. The statistical analyses on GJT and Translation tests of the L3 group suggested different levels of cross-linguistic influence, and hence partially supporting FT/FA hypothesis, L2 transfer hypothesis or CEM for each form of genitive case. Moreover, the findings indicated a possible association between the L3 group’s poor performance and their incomplete L1 acquisition due to the intense contact with the majority language (i.e., Persian as L2). Consequently, EFL teaching through learners’ language background can improve their English and preserve their background languages.
Economic Development under Persistent Currency Intervention
Authors: Jin Hailong
Published: October 2022

During the recent two decades, the spectacular economic growth of China has been under increasing scrutiny in the literature. However, prevailing discourses have either evaluated the causes/effects of the RMB exchange rate misalignment or theorized the investment/speculation channels. The implication of this persistent currency intervention (CI) regime on economic development, in comparison, remains one of the most contentious subjects in international economics. To shed light on this issue, this research develops a new macroeconomic model to address the two core attributes of China's persistent CI: the stagnant adjustment of the capital markets and the fast liberalization of the commodity markets. It investigates the impacts of macroeconomic controls on output growth and price levels from multiple aspects. It also makes several interesting discoveries in opposition to key postulations of existing macroeconomic models.
Study on Oil Price Change, Internal Regulation and Profitability Index -- Taking Oil Exploitation Industry of China as an Example
Authors: Zhu Liangfeng , Zhu Xueyi
Published: October 2022

The objective of this paper is to study the relationship between the change of oil price and the profitability of Chinese oil mining enterprises. This paper collects the relevant data of China’s oil exploitation industry and listed companies from 2011 to 2020, and makes an empirical study by using the standard value weight method and regression analysis method. The conclusions are as follows: (1) from 2011 to 2020, the average annual decline of international oil price is 6.71%, which significantly weakened the profitability of Listed Companies in China’s oil exploitation industry. (2) From 2011 to 2020, the average annual decline of gasoline prices in China is 2.61%. However, due to the implementation of the “minimum price” policy by the Chinese government, the profitability of Listed Companies in the oil exploitation industry has not decreased, but increased. (3) From 2011 to 2020, the internal control level of Listed Companies in China’s oil exploitation industry continued to decline, which was significantly negatively correlated with profitability. (4) Listed companies in China’s petroleum exploration industry adhere to the concept of sustainable development, pay attention to scientific and technological investment, effectively operate assets, increase cash flow and control costs. These measures have significantly improved the profitability of enterprises.
Patrón de actividad y relaciones ecológicas del paujil nocturno en la Amazonía norte ecuatoriana
Authors: Gallo-Viracocha Freddy , Urgilés-Verdugo Carlos
Published: October 2022

El paujil nocturno, Nothocrax urumutum, es una de las especies de aves terrestres más elusivas en bosques de tierra firme y estribaciones de la Amazonía. Con el objetivo de evaluar el patrón de actividad del paujil nocturno y compararlo con 3 especies de competidores y 3 de depredadores, se realizaron muestreos directos en 3 localidades de la Amazonía occidental ecuatoriana. Entre julio y octubre de 2015 al 2017, se usaron 90 cámaras trampa ubicadas al azar a 1 km entre sí, en un área de 90 km2. Generamos patrones de actividad mediante curvas de densidad de Kernel y estimamos el coeficiente de solapamiento entre los competidores y depredadores del paujil nocturno. El 100% de los registros fueron diurnos, con picos de actividad entre las 06:30-08:30 y las 14:00-18:00 h. Cuatro especies presentaron coeficientes de solapamiento con el paujil nocturno superiores a 60%, mientras que 2 especies no superaron el 44%. El patrón de actividad del paujil nocturno fue significativamente diferente con respecto al trompetero aligrís, corzuela roja, ocelote, taira, y no cambió con la presencia del agutí negro y del perro doméstico.
Enseñanza remota de emergencia
Authors: Estrada Lorenzo , Paz Delgado Carla Leticia
Published: October 2022

El cierre inesperado de los campus universitarios debido a la pandemia por COVID-19, ha derivado en un modelo de enseñanza remota de emergencia. Este artículo presenta los resultados de un estudio cuyo objetivo era analizar la satisfacción de los estudiantes universitarios con los entornos de aprendizaje virtual y el impacto que las variables sociodemográficas y la autoeficacia informática tienen sobre la misma. Para ello se administró un cuestionario en línea a 4,469 estudiantes de la Universidad Pedagógica Nacional Francisco Morazán (UPNFM) de Honduras. Los datos se analizaron por medio de la prueba no paramétrica de Wilcoxon, un modelo de regresión lineal y un modelo multinivel como prueba de robustez. Los resultados revelan que la satisfacción con los entornos virtuales de aprendizaje difiere según la modalidad de estudio a la que pertenece el estudiante; adicionalmente, las variables sociodemográficas y la autoeficacia informática influyen en la satisfacción.
Motivaciones para iniciar una trayectoria de formación profesional en docencia universitaria
Authors: Lozano Eduardo , Gibelli Tatiana Inés , Pintos Juan Carlos
Published: October 2022

Desde visiones teóricas sobre el estudio de las trayectorias profesionales y su incidencia en la construcción de las identidades profesionales docentes, el objetivo de este estudio consiste en describir y analizar las motivaciones que expone un grupo de profesores y profesoras de materias del campo de las ciencias naturales y la salud de la Universidad Nacional de Río Negro (Argentina) para explicar sus razones para inscribirse en una especialización en docencia universitaria. Los datos se obtuvieron a partir de una encuesta inicial y el desarrollo de entrevistas en profundidad. La interacción recursiva entre datos y visiones teóricas permitió construir diferentes categorías para dar sentido a los argumentos expuestos por los y las docentes, y muestran un complejo de motivaciones extrínsecas y de logro, también sociales y, en menor medida, intrínsecas, en las que el registro de movilizaciones generadas a partir de iniciativas y/o proyectos de nivel institucional es mínimo.
Gobernanza educativa en América Latina
Authors: Ariza Dau Marco Antonio , Ramos Ruiz José Luis
Published: October 2022

El presente artículo contribuye al debate sobre la autonomía escolar como modo de gobernanza y su efecto en la calidad y equidad en América Latina. Desde el enfoque contractual de la economía de los costos de transacción, se evalúan los efectos de la autonomía escolar en el desempeño, así como sus implicaciones en las metas de equidad en el sistema educativo. A partir de los aspectos de gobernanza medidos por el programa PISA a nivel de organizaciones escolares, se derivaron estimaciones econométricas para dos medidas de desempeño: logro y equidad. Los hallazgos sugieren que sistemas educativos más autónomos se asocian con un mejor desempeño, pero la práctica de la autonomía podría estar sesgada hacia los centros escolares que representan menor riesgo en términos de costos de transacción. Además, la autonomía escolar implica una estructura de gobernanza que conlleva riesgos de inadaptación que amenazan la naturaleza distributiva de los sistemas educativos.
Diseño y pilotaje de una app para el pensamiento crítico
Authors: Thibaut Patricia , Lizasoain Andrea , Olivares-Rodríguez Cristián , Hurtado Torres Sebastián
Published: October 2022

Pese a la urgencia del desarrollo del pensamiento crítico en un contexto mediado digitalmente e inundado de noticias falsas, los resultados de este constructo son bajos a escala internacional. Esta investigación busca aportar en esta área a partir del diseño y pilotaje de una app cuyo objetivo es desarrollar el pensamiento crítico en estudiantes de primer ciclo de universidad. Se muestra el proceso de diseño y pilotaje, así como los resultados de uso en un curso de estudiantes de primer año de universidad. Los datos se analizaron cuantitativa y cualitativamente mediante un software de análisis de corpus, el sistema de ideación del lenguaje y una rúbrica de evaluación de textos. Los datos sugieren que la app puede contribuir al desarrollo del pensamiento crítico a través de la modelación de esta habilidad. Se destacan aspectos positivos en la producción de textos argumentativos mediados por la app, junto con sugerencias de mejora.
Gobernanza, poder y autonomía universitaria en la era de la innovación
Authors: Acosta Silva Adrián
Published: October 2022

Múltiples narrativas sobre la innovación acompañan la promoción de un nuevo ciclo de políticas en la educación superior. Se trata de un conjunto de relatos cuyo significado es impreciso, pero que configura una agenda de transformaciones centradas en políticas de digitalización, virtualidad y emprendimientos institucionales asociados a la búsqueda de prestigio institucional, el incremento de la competitividad y el uso de tecnologías de información e inteligencia artificial aplicadas a los procesos de gestión institucional. ¿Cómo afectan esas políticas la gobernanza institucional y la autonomía académica e intelectual de las universidades? ¿Qué efectos tienen en la legitimidad y el poder institucional de estas organizaciones del conocimiento? El argumento que se discute es que la innovación es la expresión de una forma o etapa de neo-modernización de la educación superior que tiene implicaciones en las relaciones entre las políticas públicas, la autonomía y la gobernanza universitaria en América Latina.
Job Satisfaction of the Service Sectors Employees with Special Reference to Chennai: A Study
Authors: Rath Jayashree , Hentry Joyleen , Krithika Dr. J
Published: October 2022

Abstract: The economic well-being of both individuals and the nation is strongly affected by employment. The employee's job satisfaction is critical for effective employment. This research was carried out to identify the variables that determine employee work satisfaction. A structural questionnaire was conducted to capture the relevant information from 303 respondents. Simple correlation analysis was utilized to analyze and interpret the data. The analysis found that Job satisfaction issues connected to organizational culture, non-financial benefits, and career progression have a positive relationship with job security. Career Advancement was ranked with the least mean value, while job security was rated with the second-least mean value. Career Advancement has both a strong and relatively modest correlation with employees' performance
Changing Consumer Spending Pattern during pandemic with Special Reference to Digitals Payments
Authors: Prakash Om , VS Raam Kishore , J Krithika
Published: October 2022

Abstract: The demonetization has resulted the consumers to use the digital payment which was motivated by digital India campaign by the government of India .The Digi locker is a place where you can store your documents .The massive outbreak of the covid-19 has resulted the consumers to use the different digital payment methods available in the market. The purpose of this research is to know the spending pattern of the consumer in terms of digital payments. The research works was carried out with 172 respondents and the convenience sampling technique was adopted to collect the data. The structured questionnaire was used to collect the data. Based on the findings the suitable recommendations were made by the researchers.
A high sensitivity double-roughness-structure based on the porous silicon with graphene embedded for the sensing improvement on the non-reactive molecules
Authors: Lin Jia-Chuan , Lin Yi-Chun , Wu Chein-Hong , Settu Kalpana
Published: October 2022

A high-sensitivity double-roughness-structure (DRS) and its innovative
manufacturing processes are originally proposed for the improvement on
the sensing of the non-reactive molecule. The nitrogen molecules are
served as the non-reactive test target in the study. In the DRS, the
high roughness graphene is embedded into/onto the roughness surface of
the porous silicon, and such the porous silicon is specially made by the
“bottom-hole assisted approach” to get high-quality films. It is
proved that the DRS reveals the double reinforcement on the improvement
of the sensitivity based on the high surface-to-volume ratio in the
sensing on non-reactive molecules.
Differentiation between rebound thymic hyperplasia and thymic relapse after chemotherapy in pediatric Hodgkin lymphoma
Authors: Stovesandt Dietrich , Franke Friedrich Christian , Damek Adrian , Steglich Jonas , Kurch Lars , Hasenclever Dirk , Georgi Thomas , Wohlgemuth Walter , Mauz-Koerholz Christine , Körholz Dieter , Kluge Regine , Landman-Parker Judith , Wallace William Hamish , Fosså Alexander , Vordermark Dirk , Karlen Jonas , Fernández-Teijeiro Ana , Cepelova Michaela , Klekawka Tomasz , Attarbaschi Andishe , Ceppi Francesco , Hraskova Andrea , Uyttebroeck Anne , Beishuizen Auke , Dieckmann Karin , Leblanc Thierry , Moellers Martin , Buerke Boris
Published: October 2022

Background Rebound thymic hyperplasia (RTH) is a common
phenomenon caused by stress factors such as chemo- (CTX) or radiotherapy
with an incidence of up to 40%. Misinterpretation of RTH and thymic
lymphoma relapse (LR) may lead to unnecessary diagnostic procedures
including invasive biopsies or treatment intensification. The aim of
this study was to identify parameters that differentiate between RTH and
thymic LR in the anterior mediastinum. Methods After completion
of CTX, we analyzed CTs and MRIs of 291 patients with classical Hodgkin
lymphoma (CHL) and adequate imaging available from the European Network
for Pediatric Hodgkin lymphoma C1-trial. In all patients with biopsy
proven LR an additional FDG-PET-CT was assessed. Structure and
morphologic configuration in addition to calcifications and presence of
multiple masses in the thymic region and signs of extrathymic LR were
evaluated. Results After CTX, a significant volume increase of a
new or growing mass in the thymic space occurred in 133 of 291 patients.
Without biopsy only 100 patients could be identified as RTH or LR. No
single finding related to thymic regrowth allowed differentiation
between RTH and LR. However, the vast majority of cases with thymic LR
presented with additional increasing tumor masses (34/35). All RTH
patients (65/65) presented with isolated thymic growth.
Conclusion Isolated thymic LR is very uncommon. CHL relapse
should be suspected when increasing tumor masses are present in distant
sites outside of the thymic area. Conversely, if regrowth of lymphoma in
other sites can be excluded, an isolated thymic mass after CTX likely
represents RTH.
Clinical efficacy of cabozantinib in two pediatric patients with relapsed and refractory Ewing sarcoma
Authors: Aygüneş Utku , karagun barbaros , Sasmaz İlgen , Antmen Bulent
Published: October 2022

Ewing sarcoma is children’s second most common malignant bone tumor
after osteosarcoma. Relapsed and/or treatment-refractory cases have a
poor prognosis. Cabozantinib is a tyrosine kinase inhibitor (TKI) that
targets vascular endothelial growth factor (VEGF) and MET. Here, we
present data on two children with metastatic Ewing sarcoma who received
cabozantinib therapy. In both cases, the disease regressed
significantly, symptoms improved, and side effects were manageable.
Further research is needed to determine whether cabozantinib can
maintain sustained disease control in children with Ewing sarcoma.
The Quantum Trajectory-quided Adaptive Gaussian Methodology in the Libra Software Package
Authors: Dutra Matthew , Garashchuk Sophya , Akimov Alexey
Published: October 2022

In this account we report an implementation of the quantum
trajectory-guided adaptive Gaussian (QTAG) method in a modular
open-source Libra package for quantum dynamics calculations. The QTAG
method is based on a representation of wavefunctions in terms of a
quantum trajectory-guided adaptable Gaussians basis and is generalized
for time-propagation on multiple coupled surfaces to be applicable to
model nonadiabatic dynamics. The potential matrix elements are evaluated
within either the local harmonic or bra-ket-average (linear)
approximations to the potential energy surfaces, the latter being a more
practical option. Performance of the QTAG method is demonstrated and
discussed for the Holstein and Tully models, which are the standard
benchmarks for method development in the area of nonadiabatic dynamics.
Placental Chorioangioma Separation in Third Trimester after Fetoscopic Laser Therapy: Report of a Rare Case
Authors: Wang Ying , Wei Yuan
Published: October 2022

We performed fetoscopic laser photocoagulation at 25+1 weeks gestation
successfully. But ultrasound showed apparent separation of the
chorioangioma from the placenta at 32+2 weeks gestation. An urgent
cesarean section was performed with the delivery of a healthy female
infant. To date, there have been no reports of similar cases.
A Rare Case of 2q37 Deletion Syndrome Presented with Patent Foramen Ovale
Authors: Zaki Ahmed , Shaheen Nour , Ramadan Abdelraouf , Ramadan Abdelraouf , Nashwan Abdulqadir
Published: October 2022

Here we report a patient with 2q37 deletion syndrome confirmed by
comparative genomic hybridization (CGH) plus single nucleotide
polymorphism (SNP), who does not suffer from mental developmental
abnormalities. The patient, however, does suffer from fatigue and gross
motor delay, and the presence of a patent foramen ovale.
A Disposable Impedance-based Sensor for In-line Cell Growth Monitoring in CAR-T Cell Manufacturing
Authors: Liu Zhaonan , Jiang Xuzhou , Li Shuai , Chen Jialei , Jiang Chen , Wang Kan , Zhang Chuck , Wang Ben
Published: October 2022

This paper presents the development of low-cost, disposable
impedance-based sensors for real-time, in-line monitoring of suspension
cell culture. The sensors consist of electrical discharge machining
(EDM) cut aluminum electrodes and polydimethylsiloxane (PDMS) spacers,
low-cost materials that can be safely disposed of. Our work testifies
the capability of the low-cost sensors for in-line, non-invasive
monitoring for suspension cell growth in cell manufacturing. A hybrid
equivalent circuit model extracts key features/parameters from
intertwined impedance signals and feeds them to a novel physics-inspired
model designed for low-frequency dielectric dispersion (LFDD) to decide
viable cell count (VCC), a critical quality attribute (CQA) in cell
manufacturing. Predicted VCC trends are then compared with image-based
cell count data to verify their accuracy.
Small-molecule natural products for reversing liver fibrosis based on modulation of HSCs activation: an update
Authors: Zheng Yu , Yang Zejun , Luo Kaipei , Li Xiaofang
Published: October 2022

Liver fibrosis (LF) is a trauma repair process carried out by the liver
in response to various acute and chronic liver injuries, featured by
excessive proliferation as well as abnormal dismissal of extracellular
matrix as the main pathological features, and its continuous development
will deteriorate into cirrhosis, liver cancer as well as other
illnesses. The occurrence of LF is closely related to Hepatic stellate
cells (HSCs) stimulation, and intervention in HSCs proliferation is
expected to reverse LF. Plant-based small molecule drugs have anti-LF
effects, and their mechanisms of action are related to
anti-inflammation, anti-oxidative stress, as well as inhibition of
abnormal accumulation of extracellular matrix. Consequently, new agents
for HSCs will be required to furnish a possible curative response.
Small-molecule natural products might be attractive for LF therapy. That
is because they not only have the effect against HSCs, but also have
excellent qualities such as low toxic side effects and easy availability
from the perspective of safety and cost. In this review, we provide an
updated review of the signal transduction pathways involved in HSCs and
small-molecule natural products targeting HSCs reported in the past 3
years at home and abroad, with the aim of providing new ideas for the
development of plant-based small molecule drugs targeting HSCs to
reverse LF.
Wpływ pandemii COVID-19 na wybór miejsc zakwaterowania w trakcie wyjazdów turystycznych w Polsce
Authors: Balińska Agata , Olejniczak Wioletta
Published: October 2022

Głównym celem badań była identyfikacja i ocena potrzeb w zakresie wyboru usług noclegowych w planowaniu wyjazdów turystycznych w okresie pandemii COVID-19. Po analizie dostępnych danych wtórnych przeprowadzono własne badania ankietowe na próbie 454 aktywnych turystycznie Polaków. Wynika z nich, że na wybór miejsca zakwaterowania turystycznego wpływały w różnym stopniu takie czynniki, jak płeć, wiek, poziom wykształcenia respondentów oraz ich aktywność turystyczna przed pandemią.
Determinanty uczestnictwa kibiców w sportowych imprezach masowych
Authors: Krzyżanowska Krystyna , Reda Adam
Published: October 2022

Celem badań było rozpoznanie motywów uczestnictwa kibiców w sportowych imprezach masowych, źródeł informacji o takich wydarzeniach, częstotliwości uczestnictwa, a także korzyści i barier w udziale w tego typ imprezach. Badania empiryczne przeprowadzono w 2021 roku za pośrednictwem portalu społecznościowego Facebook wśród 207 uczestników masowych imprez sportowych. Z przeprowadzonej analizy wynika, że do najważniejszych powodów uczestnictwa kibiców w masowych imprezach sportowych należały: chęć wsparcia drużyny/zawodnika, poczucie atmosfery wydarzenia i przeżycie czegoś emocjonującego, możliwość przyjemnego spędzenia czasu wolnego, a także perspektywa dobrej rozrywki i zabawy. W wydarzeniach sportowych częściej uczestniczyli mężczyźni niż kobiety oraz osoby o większym dochodzie rozporządzalnym na 1 osobę w rodzinie. Do głównych barier uczestnictwa w imprezie sportowej respondenci zaliczyli dużą odległość od miejsca zamieszkania, wysokie koszty wyjazdu i ceny biletów.
Myocardial extracellular volume expansion in type 2 diabetes is associated with ischemic heart disease, autonomic neuropathy, and active smoking
Authors: Bojer Annemie Stege , Sørensen Martin Heyn , Gæde Peter , Madsen Per Lav
Published: October 2022

  

OBJECTIVE Myocardial interstitial fibrosis expands the extracellular volume (ECV) and is in patients with type 2 diabetes implicated in the development of heart failure. ECV can be determined with gadolinium-contrast magnetic resonance imaging. We investigated which known risk factors for cardiovascular disease were associated with increased ECV in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS 296 patients with type 2 diabetes and 25 sex and age-matched controls were included in a cross-sectional magnetic resonance imaging study. The influence of risk factors on ECV was investigated by multiple regression analysis.

RESULTS Controls and patients with type 2 diabetes without complications had similar ECV (27.4±2.1% vs 27.9±2.6%, p=0.4). Compared to patients without, ECV was significantly increased in patients with 1≥ complication (29.0±3.3%, p=0.02). Both in univariable analysis and after multivariable adjustment, ischemic heart disease, autonomic neuropathy, and active smoking were associated with increased levels of ECV. Active smoking exhibited the largest effect size (ß=2.0%-point 95% CI 0.7 to 3.3). Former smokers had similar ECV as never-smokers. Albuminuria and systolic blood pressure were inversely associated with ECV in multivariable analysis, but after adjustment for medication suspected to affect ECV, the association with albuminuria was no longer significant (p=0.1). SGLT2i treatment was not significantly associated with reduced ECV (-0.8% 95%CI -1.7 to 0.06, p=0.067).

CONCLUSION Patients with complications of diabetes have increased ECV not seen in patients without complications. Ischemic heart disease, autonomic neuropathy, and active but not former smoking was highly associated with increased ECV.