bluuebunny/crossref_metadata_2025 huggingface dataset:
Mori dreamness of blowups of weighted projective planes
Authors: Zhou Shengtian
Published: June 2021

We consider the blowup X(a, b, c) of a weighted projective space $${\mathbb {P}}(a,b,c)$$

P
(
a
,
b
,
c
)

at a general nonsingular point. We give a sufficient condition for a curve to be a negative curve on X(a, b, c) in terms of $$\chi ({\mathcal {O}}_X(C))$$

χ
(

O
X

(
C
)

)

. This can be applied to find the effective cone of X(a, b, c) and can serve as a starting point to prove the Mori dreamness of blowups of many weighted projective planes. We confirm the Mori dreamness of some X(a, b, c) as examples of our method.
ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
Authors: Zolotarov Yevgen , Ma Chao , González-Recio Irene , Hardy Serge , Franken Gijs A. C. , Uetani Noriko , Latta Femke , Kostantin Elie , Boulais Jonathan , Thibault Marie-Pier , Côté Jean-François , Díaz-Moreno Irene , Quintana Antonio Díaz , Hoenderop Joost G. J. , Martínez-Cruz Luis Alfonso , Tremblay Michel L. , de Baaij Jeroen H. F.
Published: June 2021

Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation factor-like GTPase 15 (ARL15), a small GTP-binding protein. ARL15 interacts with CNNMs at their carboxyl-terminal conserved cystathionine-β-synthase (CBS) domains. In silico modeling of the interaction between CNNM2 and ARL15 supports that the small GTPase specifically binds the CBS1 and CNBH domains. Immunocytochemical experiments demonstrate that CNNM2 and ARL15 co-localize in the kidney, with both proteins showing subcellular localization in the endoplasmic reticulum, Golgi apparatus and the plasma membrane. Most importantly, we found that ARL15 is required for forming complex N-glycosylation of CNNMs. Overexpression of ARL15 promotes complex N-glycosylation of CNNM3. Mg2+ uptake experiments with a stable isotope demonstrate that there is a significant increase of 25Mg2+ uptake upon knockdown of ARL15 in multiple kidney cancer cell lines. Altogether, our results establish ARL15 as a novel negative regulator of Mg2+ transport by promoting the complex N-glycosylation of CNNMs.
The multifaceted view of heart problem in Duchenne muscular dystrophy
Authors: Florczyk-Soluch Urszula , Polak Katarzyna , Dulak Józef
Published: June 2021

Dystrophin is a large protein serving as local scaffolding repetitively bridging cytoskeleton and the outside of striated muscle cell. As such dystrophin is a critical brick primarily in dystrophin-associated protein complex (DAGC) and in a larger submembranous unit, costamere. Accordingly, the lack of functional dystrophin laying at the root of Duchenne muscular dystrophy (DMD) drives sarcolemma instability. From this point on, the cascade inevitably leading to the death of myocyte begins. In cardiomyocytes, intracellular calcium overload and related mitochondrial-mediated cell death mainly contribute to myocardial dysfunction and dilation while other protein dysregulation and/or mislocalization may affect electrical conduction system and favor arrhythmogenesis. Although clinically DMD manifests as progressive muscle weakness and skeletal muscle symptoms define characteristic of DMD, it is the heart problem the biggest challenge that most often develop in the form of dilated cardiomyopathy (DCM). Current standards of treatment and recent progress in respiratory care, introduced in most settings in the 1990s, have improved quality of life and median life expectancy to 4th decade of patient’s age. At the same time, cardiac causes of death related to DMD increases. Despite preventive and palliative cardiac treatments available, the prognoses remain poor. Direct therapeutic targeting of dystrophin deficiency is critical, however, hindered by the large size of the dystrophin cDNA and/or stochastic, often extensive genetic changes in DMD gene. The correlation between cardiac involvement and mutations affecting specific dystrophin isoforms, may provide a mutation-specific cardiac management and novel therapeutic approaches for patients with CM. Nonetheless, the successful cardiac treatment poses a big challenge and may require combined therapy to combat dystrophin deficiency and its after-effects (critical in DMD pathogenesis). This review locates the multifaceted heart problem in the course of DMD, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.
Enhancing sensitivity of QCM for dengue type 1 virus detection using graphene-based polymer composites
Authors: Navakul Krongkaew , Sangma Chak , Yenchitsomanus Pa-thai , Chunta Suticha , Lieberzeit Peter A.
Published: June 2021

Graphene oxide-molecularly imprinted polymer composites (GO-MIP) have attracted significant attention as recognition materials in sensing due to their outstanding properties in terms of electrical and thermal conductivity, high mechanical modulus, and the comparably straightforward way to functionalize them. The aim of this study was to design a MIP-based sensor recognition material and enhance its sensitivity by blending it with GO for sensing a harmful dengue hemorrhagic fever pathogen, namely the dengue type 1 virus (DENV-1). Polymer composites comprising GO incorporated to an acrylamide (AAM)/methacrylic acid (MAA)/methyl methacrylate (MMA)/N-vinylpyrrolidone (VP) copolymer were synthesized and compared to the “pure” MIP, i.e., the copolymer without GO. The pure polymer revealed a zeta potential of + 9.9 ± 0.5 mV, whereas GO sheets prepared have a zeta potential of − 60.3 ± 2.7 mV. This results in an overall zeta potential of − 11.2 ± 0.2 mV of the composite. Such polymer composites seem appropriate to bind the positively charged DENV-1 particle (+ 42.2 ± 2.8 mV). GO-MIP coated onto 10-MHz quartz crystal microbalance (QCM) sensors indeed revealed two times sensitivity compared to sensors based on the pure MIP. Furthermore, GO-polymer composites revealed imprinting factors of up to 21, compared to 3 of the pure MIP. When plotting the sensor characteristic in a semilogarithmic way, the composite sensor shows the linear response to DENV-1 in the concentration range from 100 to 103 pfu mL−1. The corresponding limits of detection (S/N = 3) and quantification (S/N = 10) are 0.58 and 1.94 pfu mL−1, respectively. Furthermore, imprinted polymer composites selectively bind DENV-1 without significant interference: DENV-2, DENV-3, DENV-4, respectively, yield 13–16% of DENV-1 signal. The sensor requires only about 15–20 min to obtain a result.

Graphical abstract
Dynamics of Legionella Community Interactions in Response to Temperature and Disinfection Treatment: 7 Years of Investigation
Authors: Girolamini Luna , Salaris Silvano , Pascale Maria Rosaria , Mazzotta Marta , Cristino Sandra
Published: June 2021

In man-made water distribution systems, Legionella community interactions remain unknown, due to their ability to change from sessile to planktonic states or live in viable but non-culturable forms, in response to anthropic and environmental stress. During 7 years of hospital Legionella surveillance, in 191 hot water positive samples, the interactions among the Legionella species, temperature, and disinfection treatment were evaluated. Legionella was isolated following ISO 11731:2017, and identification was performed by mip gene sequencing and sequence-based typing (SBT) for L. anisa or L. rubrilucens and L. pneumophila, respectively. The species with the higher frequency of isolation was L. pneumophila serogroup 1 (78.53%; 4865.36 ± 25,479.11 cfu/L), followed by L. anisa (54.45%; 558.79 ± 2637.41 cfu/L) and L. rubrilucens (21.99%; 307.73 ± 1574.95 cfu/L), which were sometimes present together. Spearman’s rho correlation test was conducted among the species with respect to temperature and disinfectant (H2O2/Ag+). The results showed a generally positive interaction among these species sharing the same environment, except for competition between L. anisa and L. rubrilucens. High temperature (48.83 ± 2.59 °C) and disinfection treatment (11.58 ± 4.99 mg/L) affected the presence of these species. An exception was observed with L. anisa, which showed disinfection treatment resistance. For the purposes of environmental surveillance, it is fundamental to better understand the interactions and dynamic of the Legionella community in man-made water systems in order to choose the proper physical or chemical treatments. The simultaneous presence of different Legionella species could result in an increased resistance to high temperature and disinfectant treatment, leading to changes in contamination level and species diversity.
Cyanophage Distribution Across European Lakes of the Temperate-Humid Continental Climate Zone Assessed Using PCR-Based Genetic Markers
Authors: Jaskulska Aleksandra , Šulčius Sigitas , Kokociński Mikołaj , Koreivienė Judita , Nájera Arnoldo Font , Mankiewicz-Boczek Joanna
Published: June 2021

Studies of the diversity and distribution of freshwater cyanophages are generally limited to the small geographical areas, in many cases including only one or few lakes. Data from dozens of various lakes distributed at a larger distance are necessary to understand their spatial distribution and sensitivity to biotic and abiotic factors. Thus, the objective of this study was to analyze the diversity and distribution of cyanophages within the infected cells using marker genes (psbA, nblA, and g91) in 21 Polish and Lithuanian lakes. Physicochemical factors that might be related to them were also analyzed. The results demonstrated that genetic markers representing cyanophages were observed in most lakes studied. The frequently detected gene was psbA with 88% of cyanophage-positive samples, while nblA and g91 were found in approximately 50% of lakes. The DNA sequence analyses for each gene demonstrated low variability between them, although the psbA sequences branched within the larger cluster of marine Synechoccocuss counterparts. The principal component analysis allowed to identify significant variation between the lakes that presented high and low cyanobacterial biomass. The lakes with high cyanobacterial biomass were further separated by country and the different diversity of cyanobacteria species, particularly Planktothrix agardhii, was dominant in the Polish lakes and Planktolyngbya limnetica in the Lithuanian lakes. The total phosphorous and the presence of cyanophage genes psbA and nblA were the most important factors that allowed differentiation for the Polish lakes, while the pH and the genes g91 and nblA for the Lithuanian lakes.
The cavernous carotid inferolateral trunk and persistent primitive maxillary arteries: analysis of dissected arterially injected fetal specimens and high-resolution micro-CT of the dog’s anastomotic arteries
Authors: Kier E. Leon , Conlogue Gerald J. , Staib Lawrence H.
Published: June 2021

Purpose

The presence of a persistent primitive maxillary artery is described in the literature dealing with the development of the cavernous carotid inferolateral trunk, and the relevant similarities of the cranial circulation of the human and dog. The literature includes no dissection photographs of the above-mentioned two human fetal arteries, only diagrammatic representations. This study’s objectives were to analyze photographs of fetal dissections for the presence of these two arteries, and also investigate the possibility of obtaining, in preserved dog specimens, high-resolution micro-CT imaging of arteries homologous with the above-mentioned two human arteries.

Methods

The literature describing the embryologic development of the cavernous carotid inferolateral trunk, the persistent primitive maxillary arteries, and their homologies in the dog was reviewed. Relevant dissections of fetal specimens were analyzed. High-resolution micro-CT images of un-dissected dog arteries were produced and analyzed.

Results

Photographs of fetal specimen dissections demonstrate the cavernous carotid inferolateral trunk. A separate persistent primitive maxillary artery was not present in the dissected specimens. High-resolution micro-CT images of the dog demonstrate homologous arteries with segments of the human inferolateral trunk, and other skull base and brain arteries.

Conclusion

This investigation provides the only photographs in the literature of dissected human fetal cavernous carotid inferolateral trunks. A persistent primitive maxillary artery was not present in the dissected specimens and is a non-existent structure, likely a previously misidentified carotid inferolateral trunk. High-resolution micro-CT images of the dog visualized arteries that are homologous to segments of the human cavernous carotid inferolateral trunk artery.
The Clock Drawing Test as a predictor of cognitive decline in non-demented stroke patients
Authors: Cova Ilaria , Mele Francesco , Zerini Federica , Maggiore Laura , Rosa Silvia , Cucumo Valentina , Brambilla Michela , Nicotra Alessia , Maestri Giorgia , Bertora Pierluigi , Pomati Simone , Pantoni Leonardo
Published: June 2021

Background

The early detection of patients at risk of post-stroke cognitive impairment (PSCI) may help planning subacute and long-term care. We aimed to determine the predictivity of two screening cognitive tests on the occurrence of mild cognitive impairment or dementia in acute stroke patients.

Methods

A cognitive assessment within a few days of ischemic or hemorrhagic stroke was performed in patients consecutively admitted to a stroke unit over 14 months by means of the Clock Drawing Test (CDT) and the Montreal Cognitive Assessment-Basic (MoCA-B).

Results

Out of 191 stroke survivors who were non-demented at baseline, 168 attended at least one follow-up visit. At follow-up (mean duration ± SD 12.8 ± 8.7 months), 28 (18.9%) incident cases of MCI and 27 (18%) cases of dementia were recorded. In comparison with patients who remained cognitively stable at follow-up, these patients were older, less educated, had more comorbidities, a higher score on the National Institutes of Health Stroke Scale (NIHSS) at admission, more severe cerebral atrophy, and lower MoCA-B and CDT scores at baseline. In multi-adjusted (for age, education, comorbidities score, NIHSS at admission and atrophy score) model, a pathological score on baseline CDT (< 6.55) was associated with a higher risk of PSCI at follow-up (HR 2.022; 95% CI 1.025–3.989, p < 0.05) with respect to non-pathological scores. A pathological baseline score on MoCA-B (< 24) did not predict increased risk of cognitive decline at follow-up nor increased predictivity of stand-alone CDT.

Conclusion

A bedside cognitive screening with the CDT helps identifying patients at higher risk of PSCI.
Response inhibition deficits are positively associated with trait rumination, but attentional inhibition deficits are not: aggressive behaviors and interpersonal stressors as mediators
Authors: Hasegawa Akira , Matsumoto Noboru , Yamashita Yuko , Tanaka Keisuke , Kawaguchi Jun , Yamamoto Tetsuya
Published: June 2021

Previous findings on relationships between inhibition that is a core executive function, and trait rumination have been inconsistent. This inconsistency could be overcome by investigating the association between rumination and the two subcomponents of inhibition: response inhibition and attentional inhibition. This study examined whether and how response inhibition and attentional inhibition were related to rumination as well as worry. University students in Japan (N = 213) conducted the Go/No-Go Task and the Modified Stroop Task. They also completed self-report measures of depression, trait rumination, trait worry, stressors, and aggressive behaviors. Results indicated that response inhibition deficits were positively associated with trait rumination, and this association was mediated by increases in aggressive behaviors and interpersonal stressors. The associations between these variables remained significant even after controlling for depression level. There were no significant direct or indirect associations between attentional inhibition deficits and rumination. These results suggest that response inhibition deficits, among the subcomponents of inhibition, have an indirect positive association with rumination through interpersonal processes. Results also showed nonsignificant differences between rumination and worry in the magnitude of correlation coefficients with the two subcomponents of inhibition. Therefore, it remains unclear whether the positive association with response inhibition is unique to rumination.
A touch of hierarchy: population receptive fields reveal fingertip integration in Brodmann areas in human primary somatosensory cortex
Authors: Schellekens W. , Thio M. , Badde S. , Winawer J. , Ramsey N. , Petridou N.
Published: June 2021

Several neuroimaging studies have shown the somatotopy of body part representations in primary somatosensory cortex (S1), but the functional hierarchy of distinct subregions in human S1 has not been adequately addressed. The current study investigates the functional hierarchy of cyto-architectonically distinct regions, Brodmann areas BA3, BA1, and BA2, in human S1. During functional MRI experiments, we presented participants with vibrotactile stimulation of the fingertips at three different vibration frequencies. Using population Receptive Field (pRF) modeling of the fMRI BOLD activity, we identified the hand region in S1 and the somatotopy of the fingertips. For each voxel, the pRF center indicates the finger that most effectively drives the BOLD signal, and the pRF size measures the spatial somatic pooling of fingertips. We find a systematic relationship of pRF sizes from lower-order areas to higher-order areas. Specifically, we found that pRF sizes are smallest in BA3, increase slightly towards BA1, and are largest in BA2, paralleling the increase in visual receptive field size as one ascends the visual hierarchy. Additionally, we find that the time-to-peak of the hemodynamic response in BA3 is roughly 0.5 s earlier compared to BA1 and BA2, further supporting the notion of a functional hierarchy of subregions in S1. These results were obtained during stimulation of different mechanoreceptors, suggesting that different afferent fibers leading up to S1 feed into the same cortical hierarchy.
Expression of estrogen-related receptors in ovarian cancer and impact on survival
Authors: Schüler-Toprak Susanne , Weber Florian , Skrzypczak Maciej , Ortmann Olaf , Treeck Oliver
Published: June 2021

Purpose

This study further approaches the role of estrogen-related receptors (ERRs) in ovarian cancer. Protein expression of ERRα, ERRβ and ERRγ in ovarian cancer was assessed and was correlated with ovarian cancer markers, steroid hormone receptors and cancer-associated genes. Additionally, we examined to what extent expression of ERRs affects survival of ovarian cancer patients.

Methods

For this purpose, we established a tissue microarray from 208 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins.

Results

ERRα and ERRγ protein could be detected at different levels in more than 90% of all ovarian cancer tissues, whereas expression of ERRβ was observed in 82.2% of the cases. ERRα was found to positively correlate with ovarian cancer marker CEA (p < 0.005) and ERRγ correlated with ERα (p < 0.001). Univariate survival analyses revealed that ERRα expression did not affect overall (OS) or progression-free survival (PFS) of ovarian cancer patients. In contrast, higher expression of ERRβ in serous ovarian cancers was found to lead to a significantly decreased OS (p < 0.05). The strongest impact on survival was exhibited by ERRγ. Lower expression of this receptor in women with serous ovarian cancers indicated significantly increased OS compared to those with higher levels of ERRγ (p < 0.05). Multivariate survival analyses revealed ERRγ as an independent prognostic marker regarding OS of patients with serous ovarian cancer.

Conclusion

Our data demonstrating that ERR proteins are frequently expressed in ovarian cancer and high levels of ERRβ and ERRγ significantly decreased OS of serous ovarian cancer patients suggest that these proteins might be interesting therapy targets in this cancer entity.
Detecting and learning from unknown by extremely weak supervision: exploratory classifier (xClass)
Authors: Angelov Plamen , Soares Eduardo
Published: June 2021

In this paper, we break with the traditional approach to classification, which is regarded as a form of supervised learning. We offer a method and algorithm, which make possible fully autonomous (unsupervised) detection of new classes, and learning following a very parsimonious training priming (few labeled data samples only). Moreover, new unknown classes may appear at a later stage and the proposed xClass method and algorithm are able to successfully discover this and learn from the data autonomously. Furthermore, the features (inputs to the classifier) are automatically sub-selected by the algorithm based on the accumulated data density per feature per class. In addition, the automatically generated model is easy to interpret and is locally generative and based on prototypes which define the modes of the data distribution. As a result, a highly efficient, lean, human-understandable, autonomously self-learning model (which only needs an extremely parsimonious priming) emerges from the data. To validate our proposal, we approbated it on four challenging problems, including imbalanced Faces-1999 data base, Caltech-101 dataset, vehicles dataset, and iRoads dataset, which is a dataset of images of autonomous driving scenarios. Not only we achieved higher precision (in one of the problems outperforming by 25% all other methods), but, more significantly, we only used a single class beforehand, while other methods used all the available classes and we generated interpretable models with smaller number of features used, through extremely weak and weak supervision. We demonstrated the ability to detect and learn new classes for both images and numerical examples.
Getting started with uncertainty evaluation using the Monte Carlo method in R
Authors: Veen Adriaan M. H. van der , Cox Maurice G.
Published: June 2021

The evaluation of measurement uncertainty is often perceived by laboratory staff as complex and quite distant from daily practice. Nevertheless, standards such as ISO/IEC 17025, ISO 15189 and ISO 17034 that specify requirements for laboratories to enable them to demonstrate they operate competently, and are able to generate valid results, require that measurement uncertainty is evaluated and reported. In response to this need, a European project entitled “Advancing measurement uncertainty—comprehensive examples for key international standards” started in July 2018 that aims at developing examples that contribute to a better understanding of what is required and aid in implementing such evaluations in calibration, testing and research. The principle applied in the project is “learning by example”. Past experience with guidance documents such as EA 4/02 and the Eurachem/CITAC guide on measurement uncertainty has shown that for practitioners it is often easier to rework and adapt an existing example than to try to develop something from scratch. This introductory paper describes how the Monte Carlo method of GUM (Guide to the expression of Uncertainty in Measurement) Supplement 1 can be implemented in R, an environment for mathematical and statistical computing. An implementation of the law of propagation of uncertainty is also presented in the same environment, taking advantage of the possibility of evaluating the partial derivatives numerically, so that these do not need to be derived by analytic differentiation. The implementations are shown for the computation of the molar mass of phenol from standard atomic masses and the well-known mass calibration example from EA 4/02.
Prioritizing core components of successful transitions from child to adult mental health care: a national Delphi survey with youth, caregivers, and health professionals
Authors: Cleverley Kristin , McCann Emma , O’Brien David , Davies Julia , Bennett Kathryn , Brennenstuhl Sarah , Courey Lynn , Henderson Joanna , Jeffs Lianne , Miller Joshua , Pignatiello Tony , Rong Jessica , Rowland Emily , Stevens Katye , Szatmari Peter
Published: June 2021

Youth accessing mental health care often experience a disruption in care as they attempt to transition between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS). Few studies have evaluated interventions seeking to improve the experience and outcomes of CAMHS–AMHS transitions, in part due to lack of consensus on what constitutes best practices in intervention success. As such, the aim of this study was to engage patients, caregivers, and clinicians to prioritize core components of successful CAMHS–AMHS transitions which can be used in the design or evaluation of transition interventions. As such, a Delphi study was conducted to determine core components of successful CAMHS–AMHS transitions. Guided by the principles of patient-oriented research, three balanced expert panels consisting of youth, caregivers, and clinicians ranked and provided feedback on the importance and feasibility of core components of CAMHS-AMHS transitions. Components endorsed as feasible or important with ≥ 70% agreement from any panel moved to the next round. As a result, a list of 26 core components of CAMHS–AMHS transitions has been refined which can be used in the design, implementation, or evaluation of interventions intended to improve transition experiences and outcomes for youth in mental health care. Youth and families were engaged in an expert advisory role throughout the research process, contributing their important perspectives to the design and implementation of this study, as well as interpretation of the findings.
Age at school entry and reported symptoms of attention-deficit/hyperactivity in first graders: results of the prospective cohort study ikidS
Authors: Diefenbach Christiane , Schmidt Martina F. , Huss Michael , König Jochem , Urschitz Michael S. ,   The ikidS Study Group, Hoffmann Dietmar , Blettner Maria , Queisser-Wahrendorf Annette , Wiesel Awi , Zepp Fred , Faber Jörg , Gehring Stephan , Mildenberger Eva , Letzel Stephan , Elflein Heike , Schuster Alexander K. , Willershausen Brita , Weusmann Jens , Matthias Christoph , Läßig Anne , Imhof Margarete , Simon Perikles
Published: June 2021

Young age at school entry (ASE) is related to attention-deficit/hyperactivity disorder in higher grades. The reason for this association is unclear, but medical oversupply and stress-related factors are discussed. We aimed to investigate whether ASE is associated with reported symptoms of attention-deficit/hyperactivity (ADH) already in first grade. Data of a population-based prospective cohort study (N = 2003; Mainz-Bingen region; Rhineland-Palatinate; Germany) with baseline assessments prior to school entry and two follow-ups during first grade were analysed. ADH symptoms were assessed by parent and teacher versions of the Strengths and Difficulties Questionnaire. Associations between ASE and scores of the hyperactivity/inattention subscale (range 0–10) were investigated by regression analysis and adjusted for potential confounders and baseline symptoms prior to school entry. In total, 1633 children (52% boys, mean ASE 6.5 years) were included. There were no relationships between ASE and parent-reported scores of the hyperactivity/inattention subscale prior to school entry and 3 months thereafter. However, at the end of first grade, ASE was negatively associated with the hyperactivity/inattention subscale in parent (− 0.7 subscale points per year ASE, standard error = 0.16, p < 0.0001) and teacher reports (− 1.2 subscale points per year ASE, standard error = 0.25, p < 0.0001). This ASE effect appeared more pronounced in girls than in boys. Young ASE is related to more reported symptoms of ADH at the end of first grade, but not before. The evolvement of this effect during first grade may be a clue to ASE-related stress factors.
Scalable online first-order monitoring
Authors: Schneider Joshua , Basin David , Brix Frederik , Krstić Srđan , Traytel Dmitriy
Published: June 2021

Online monitoring is the task of identifying complex temporal patterns while incrementally processing streams of data-carrying events. Existing state-of-the-art monitors for first-order patterns, which may refer to and quantify over data values, can process streams of modest velocity in real-time. We show how to scale up first-order monitoring to substantially higher velocities by slicing the stream, based on the events’ data values, into substreams that can be monitored independently. Because monitoring is not embarrassingly parallel in general, slicing can lead to data duplication. To reduce this overhead, we adapt hash-based partitioning techniques from databases to the monitoring setting. We implement these techniques in an automatic data slicer based on Apache Flink and empirically evaluate its performance using two tools—MonPoly and DejaVu—to monitor the substreams. Our evaluation attests to substantial scalability improvements for both tools.
Probabilistic assessment of seismic-induced slope displacements: an application in Italy
Authors: Rollo Fabio , Rampello Sebastiano
Published: June 2021

Earthquake-induced slope instability is one of the most important hazards related to ground shaking, causing damages to the environment and, often, casualties. Therefore, it is important to assess the seismic performance of slopes, especially in the near fault regions, evaluating the permanent displacements induced by seismic loading. This paper applies a probabilistic approach to evaluate the seismic performance of slopes using an updated database of ground motions recorded during the earthquakes occurred in Italy. The main advantage of this approach is that of accounting for the aleatory variability of both ground motions and prediction of seismic-induced displacements of slopes. The results are presented in terms of hazard curves, showing the annual rate of exceedance of permanent slope displacement evaluated using ground motion data provided by a standard probabilistic hazard analysis and a series of semi-empirical relationships linking the permanent displacements of slopes to one or more ground motion parameters. The procedure has been implemented on a regional scale to produce seismic landslide hazard maps for the Irpinia district, in Southern Italy, characterised by a severe seismic hazard. Seismic landslide hazard maps represent a useful tool for practitioners and government agencies for a regional planning to identify and monitor zones that are potentially susceptible to earthquake-induced slope instability, thus requiring further detailed, site-specific studies.
Lag times and invasion dynamics of established and emerging weeds: insights from herbarium records of Queensland, Australia
Authors: Osunkoya Olusegun O. , Lock Claire B. , Dhileepan Kunjithapatham , Buru Joshua C.
Published: June 2021

Herbarium records provide comprehensive information on plant distribution, offering opportunities to construct invasion curves of introduced species, estimate their rates and patterns of expansions in novel ranges, as well as identifying lag times and hence “sleeper weeds”, if any. Lag times especially have rarely been determined for many introduced species, including weeds in the State of Queensland, Australia as the trait is thought to be unpredictable and cannot be screened for. Using herbarium records (1850–2010), we generated various invasiveness indices, and developed simple invasion and standardised proportion curves of changes in distribution with time for ~ 100 established and emerging weed species of Queensland. Four major periods (decades) of increased weed spread (spikes) were identified: 1850s, 1900–1920, 1950–1960 and 2000–2010, especially for grasses and trees/shrubs. Many weeds with spikes in spread periods did so only 1–2 decadal times, except for a few species with higher spike frequencies > 6; the majority of these spikes occurred recently (1950–1990). A significant proportion (~ 60%) of Queensland’s weeds exhibit non-linear increase in spread with time, and hence have lag phases (mean: 45.9 years; range: 12–126 years); of these lag-phase species, 39% are “sleeper” weeds with > 50 years of lag time (mainly trees/shrubs and grasses). Twelve traits of invasiveness, including lag time and species-specific/historical factors were screened, of which frequency of invasion waves, spread rates and residence time were the main drivers of weeds’ distribution. The low predictive power of lag time on weed distribution suggests that retrospective analyses offer little hope for a robust generalisation to identify weeds of tomorrow.
Prioritisation and design of clinical trials
Authors: Heath Anna , Myriam Hunink M. G. , Krijkamp Eline , Pechlivanoglou Petros
Published: June 2021

Clinical trials require participation of numerous patients, enormous research resources and substantial public funding. Time-consuming trials lead to delayed implementation of beneficial interventions and to reduced benefit to patients. This manuscript discusses two methods for the allocation of research resources and reviews a framework for prioritisation and design of clinical trials. The traditional error-driven approach of clinical trial design controls for type I and II errors. However, controlling for those statistical errors has limited relevance to policy makers. Therefore, this error-driven approach can be inefficient, waste research resources and lead to research with limited impact on daily practice. The novel value-driven approach assesses the currently available evidence and focuses on designing clinical trials that directly inform policy and treatment decisions. Estimating the net value of collecting further information, prior to undertaking a trial, informs a decision maker whether a clinical or health policy decision can be made with current information or if collection of extra evidence is justified. Additionally, estimating the net value of new information guides study design, data collection choices, and sample size estimation. The value-driven approach ensures the efficient use of research resources, reduces unnecessary burden to trial participants, and accelerates implementation of beneficial healthcare interventions.
The Impact of Bilingualism on Everyday Executive Functions of English-Arabic Autistic Children: Through a Parent-Teacher Lens
Authors: Sharaan Shereen , MacPherson Sarah E. , Fletcher-Watson Sue
Published: June 2021

There is evidence that autistic children may have reduced executive function skills, contributing to day-to-day difficulties, but much remains unknown regarding the influence of bilingualism. We investigated its influence on sustained attention, interference control, flexible switching and working memory, in Arabic-English autistic (n = 27) and typically developing peers (n = 53) children, aged 5 to 12 years old. Parents and teachers completed rating measures assessing children’s daily EF abilities. Results showed generalized positive effects for bilingual autistic children relative to their monolingual peers across all EF domains, but using parent ratings only. The findings indicate that bilingualism does not negatively impact the executive function skills of autistic children, and that it might mitigate difficulties faced on a day-to-day basis.
Gene-flow within a butterfly metapopulation: the marsh fritillary Euphydryas aurinia in western Bohemia (Czech Republic)
Authors: Junker Marius , Konvicka Martin , Zimmermann Kamil , Schmitt Thomas
Published: June 2021

In human-altered landscapes, species with specific habitat requirements tend to persist as metapopulations, forming colonies restricted to patches of suitable habitats, displaying mutually independent within-patch dynamics and interconnected by inter-colony movements of individuals. Despite intuitive appeal and both empirical and analytical evidence, metapopulations of only relatively few butterfly systems had been both monitored for multiple years to quantify metapopulation dynamics, and assayed from the point of view of population genetics. We used allozyme analysis to study the genetic make-up of a metapopulation of a declining and EU-protected butterfly,Euphydryas aurinia, inhabiting humid grasslands in western Czech Republic, and reanalysed previously published demography and dispersal data to interpret the patterns. For 497 colony x year visits to the 97 colonies known at that time, we found annual extinction and colonisation probabilities roughly equal to 4%. The genetic diversity within colonies was intermediate or high for all assessed parameters of population genetic diversity and hence higher than expected for such a habitat specialist species. All the standard genetic diversity measures were positively correlated to adult counts and colony areas, but the correlations were weak and rarely significant, probably due to the rapid within-colony population dynamics. Only very weak correlations applied to larval nests numbers. We conclude that the entirety of colonies forms a well-connected system for their majority. Especially in its core parts, we assume a metapopulation structure with a dynamic equilibrium between local extinction and recolonization. It is vital to conserve in particular these structures of large and interconnected colonies.

Implications for insect conservation:Conservation measures should focus on considering more in depth the habitat requirements ofE. auriniafor management plans and on stabilisation strategies for colonies, especially of peripheral ones, e.g. by habitat restoration.
Subtropical Mode Water in a recent persisting Kuroshio large-meander period: part I—formation and advection over the entire distribution region
Authors: Oka Eitarou , Nishikawa Hatsumi , Sugimoto Shusaku , Qiu Bo , Schneider Niklas
Published: June 2021

Since August 2017, the Kuroshio has taken a large-meander (LM) path, which has forced the Kuroshio extension (KE) to be in its stable state against its wind-forced decadal variability. How such current conditions have impacted the formation and advection of North Pacific subtropical mode water (STMW) over its distribution region was examined using Argo float data during 2005–2020. Out of the whole STMW defined as a low-potential vorticity layer of 16–19.5 ºC, a relatively cold variety of 16–18 ºC, which was formed south of the KE and advected westward and southward, occupied more than 80% of the total volume. The formation rate of the 16–18 ºC variety was low during 2006–2009 in an unstable-KE period and high during 2010–2015 in a stable-KE period, and then dropped drastically in 2016 despite the KE still being in the stable state. After a short unstable-KE period in 2016–2017, the LM-forced, stable-KE period began, but the formation rate of the 16–18 ºC variety has not restored, possibly due to stronger background stratification propagated from the central North Pacific. In addition, the 16–18 ºC variety has had to make a southern detour around the LM, and its westward advection from the formation region south of the KE to the region south of Japan has been significantly decreased, possibly because it is dissipated more strongly over a southern part of the Izu–Ogasawara Ridge. Due to such decline in the formation and advection, the volume of the 16–18 ºC variety and hence that of the whole STMW have gradually decreased since 2016.
Numerical Solution of the Parametric Diffusion Equation by Deep Neural Networks
Authors: Geist Moritz , Petersen Philipp , Raslan Mones , Schneider Reinhold , Kutyniok Gitta
Published: June 2021

We perform a comprehensive numerical study of the effect of approximation-theoretical results for neural networks on practical learning problems in the context of numerical analysis. As the underlying model, we study the machine-learning-based solution of parametric partial differential equations. Here, approximation theory for fully-connected neural networks predicts that the performance of the model should depend only very mildly on the dimension of the parameter space and is determined by the intrinsic dimension of the solution manifold of the parametric partial differential equation. We use various methods to establish comparability between test-cases by minimizing the effect of the choice of test-cases on the optimization and sampling aspects of the learning problem. We find strong support for the hypothesis that approximation-theoretical effects heavily influence the practical behavior of learning problems in numerical analysis. Turning to practically more successful and modern architectures, at the end of this study we derive improved error bounds by focusing on convolutional neural networks.
Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum
Authors: Malik Erum , Phoenix David A. , Snape Timothy J. , Harris Frederick , Singh Jaipaul , Morton Leslie H. G. , Dennison Sarah R.
Published: June 2021

Here the hypothesis that linearized esculentin 2EM (E2EM-lin) from Glandirana emeljanovi possesses pH dependent activity is investigated. The peptide showed weak activity against Gram-negative bacteria (MLCs ≥ 75.0 μM) but potent efficacy towards Gram-positive bacteria (MLCs ≤ 6.25 μM). E2EM-lin adopted an α-helical structure in the presence of bacterial membranes that increased as pH was increased from 6 to 8 (↑ 15.5–26.9%), whilst similar increases in pH enhanced the ability of the peptide to penetrate (↑ 2.3–5.1 mN m−1) and lyse (↑ 15.1–32.5%) these membranes. Theoretical analysis predicted that this membranolytic mechanism involved a tilted segment, that increased along the α-helical long axis of E2EM-lin (1–23) in the N → C direction, with −  < µH > increasing overall from circa − 0.8 to − 0.3. In combination, these data showed that E2EM-lin killed bacteria via novel mechanisms that were enhanced by alkaline conditions and involved the formation of tilted and membranolytic, α-helical structure. The preference of E2EM-lin for Gram-positive bacteria over Gram-negative organisms was primarily driven by the superior ability of phosphatidylglycerol to induce α-helical structure in the peptide as compared to phosphatidylethanolamine. These data were used to generate a novel pore-forming model for the membranolytic activity of E2EM-lin, which would appear to be the first, major reported instance of pH dependent AMPs with alkaline optima using tilted structure to drive a pore-forming process. It is proposed that E2EM-lin has the potential for development to serve purposes ranging from therapeutic usage, such as chronic wound disinfection, to food preservation by killing food spoilage organisms.
Critical thresholds for mode-coupling instability in viscoelastic sliding contacts
Authors: Papangelo Antonio , Putignano Carmine , Hoffmann Norbert
Published: June 2021

Mode-coupling instabilities are known to trigger self-excited vibrations in sliding contacts. Here, the conditions for mode-coupling (or “flutter”) instability in the contact between a spherical oscillator and a moving viscoelastic substrate are studied. The work extends the classical 2-Degrees-Of-Freedom conveyor belt model and accounts for viscoelastic dissipation in the substrate, adhesive friction at the interface and nonlinear normal contact stiffness as derived from numerical simulations based on a boundary element method capable of accounting for linear viscoelastic effects. The linear stability boundaries are analytically estimated in the limits of very low and very high substrate velocity, while in the intermediate range of velocity the eigenvalue problem is solved numerically. It is shown how the system stability depends on externally imposed parameters, such as the substrate velocity and the normal load applied, and on contact parameters such as the interfacial shear strength $$\tau _{0}$$

τ
0

and the viscoelastic friction coefficient. In particular, for a given substrate velocity, there exist a critical shear strength $$\tau _{0,crit}$$

τ

0
,
c
r
i
t

and normal load $$F_{n,crit}$$

F

n
,
c
r
i
t

, which trigger mode-coupling instability: for shear stresses larger than $$\tau _{0,crit}$$

τ

0
,
c
r
i
t

or normal load smaller than $$F_{n,crit}$$

F

n
,
c
r
i
t

, self-excited vibrations have to be expected.
Laying ghosts to rest
Authors: O’Conaill Donnchadh
Published: June 2021

One of the most widely-discussed arguments against physcialism appeals to the conceivability of zombies, being which are physically or functionally identical to humans but which have no conscious experiences. Philip Goff (Philos Phenomenol Res 81(1): 119–139, 2010; Consci Cognit 21(2): 742–746, 2012a; in Sprevak M, Kallestrup J (eds) New waves in philosophy of mind. Palgrave, 2014) has recently presented a number of different anti-physicalist arguments appealing to the conceivability of ghosts, entities whose nature is exhausted by their being conscious. If ghosts are conceivable, this would rule out a priori physicalism. If the conceivability of ghosts entails that they are metaphysically possible, then this forms the basis for arguments against a posteriori physicalism. Drawing on work on conceivability by Peter Kung (Philos Phenomenol Res 81(3):620–663, 2010, Noûs 50(1): 90–120, 2016) and my own discussion of arguments which appeal to the conceivability of zombies (O’Conaill in Mihretu P Guta (ed) Consciousness and the ontology of properties. Routledge, New York, 2019), I shall argue that ghosts are conceivable, but that what allows us to conceive of them (our ability to make certain stipulations about the scenarios we conceive) undermines the belief that conceivability is a reliable guide to possibility. While this does not undermine Goff’s argument against a priori phyiscalism, it suggests that a posteriori physicalists need not be haunted by ghosts.
The power of shared positivity: organizational psychological capital and firm performance during exogenous crises
Authors: Grözinger Ann-Christin , Wolff Sven , Ruf Philipp Julian , Moog Petra
Published: June 2021

This study examines the influence of organizational psychological capital on the performance of small and medium-sized companies (SMEs) during crises. We argue that SMEs use their intangible resources to cope with difficult situations such as the COVID-19 pandemic. Therefore, we investigate how organizational psychological capital impacts performance and creative innovation through such intangible resources, namely, organizational citizenship behavior, solidarity, and cooperation. Methodologically, we combine structural equation modelling and regression analysis on a dataset of 379 SMEs. Our results support the notion that organizational psychological capital positively influences creative innovation of SMEs and thus performance during crises. Our research contributes to the organizational behavior literature by showing that psychological resources of SMEs can strengthen performance in times of crisis and help to prepare for future ones.
Neutron Insights into Sorption Enhanced Methanol Catalysis
Authors: Nikolic Marin , Daemen Luke , Ramirez-Cuesta Anibal J. , Xicohtencatl Rafael Balderas , Cheng Yongqiang , Putnam Seth T. , Stadie Nicholas P. , Liu Xiaochun , Terreni Jasmin , Borgschulte Andreas
Published: June 2021

Sorption enhanced methanol production makes use of the equilibrium shift of the $$\hbox {CO}_2$$

CO
2

hydrogenation reaction towards the desired products. However, the increased complexity of the catalyst system leads to additional reactions and thus side products such as dimethyl ether, and complicates the analysis of the reaction mechanism. On the other hand, the unusually high concentration of intermediates and products in the sorbent facilitates the use of inelastic neutron scattering (INS) spectroscopy. Despite being a post-mortem method, the INS data revealed the change of the reaction path during sorption catalysis. Concretely, the experiments indicate that the varying water partial pressure due to the adsorption saturation of the zeolite sorbent influences the progress of the reaction steps in which water is involved. Experiments with model catalysts support the INS findings.