bluuebunny/crossref_metadata_2025 huggingface dataset:
Increased Circulating Pentraxin 3 Levels in Patients with Rheumatoid Arthritis: A
Meta-analysis
Authors: Guan Shi-Yang , Chen Yuting , Shao Ming , Yang Hui , Xu Wei , Shuai Zongwen , Zhao Hui , Zhao Dahai , Pan Faming
Published: June 2022

Background:

Pentraxin 3 (PTX3) as a soluble pattern recognition molecule not only acts as a promising indicator reflecting the disease activity of rheumatoid arthritis (RA) patients, but exerts essential pathogenic roles in the progression of RA and serves as a potential therapeutic target for RA patients. Our study intends to systematically evaluate the circulating PTX3 levels and their potential influencing factors in RA patients.

Methods:

Articles regarding the circulating PTX3 levels of RA patients were identified in Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Cochrane databases. Standardized mean difference (SMD) and corresponding 95% confidence intervals (95% CI) were calculated and further illustrated by the forest plot. Egger’s regression test and sensitivity analysis were conducted to assess the publication bias and stability of the results, respectively.

Results:

Twenty articles with 21 individual studies were recruited in our meta-analysis. The overall results revealed that compared with healthy controls, RA patients had significantly higher circulating PTX3 levels (pooled SMD = 0.97, 95% CI: 0.48 to 1.45). Subgroup analyses further demonstrated that compared with healthy controls, RA patients of age ≤ 50 years, 2.6 < disease activity score in 28 joints (DAS28) ≤ 3.2, 3.2 < DAS28 ≤ 5.1, DAS28 > 5.1, C-reactive protein (CRP) levels > 10 mg/L, erythrocyte sedimentation rate (ESR) > 20 mm/h, and disease duration > 5 years had significantly higher circulating PTX3 levels, respectively; whereas RA patients of age > 50 years, DAS28 ≤ 2.6, CRP levels ≤ 10 mg/L, ESR ≤ 20 mm/h and disease duration ≤ 5 years had no significantly altered circulating PTX3 levels, respectively. Additionally, no matter the patients of Caucasian ethnicity or not, circulating PTX3 levels were significantly increased in RA patients.

Conclusion:

Compared with healthy controls, circulating PTX3 levels are significantly increased in RA patients, which are influenced by the age, disease activity, CRP levels, ESR, and disease duration of the patients.
Thiourea-Catalyzed Amidation of Esters: A New Method for the Preparation
of Amides
Authors: Davis Todd A. , Garza Audrey B. , Miller Rebecca G. , Gardner Steven B. , Fuhrer Timothy J. , Campbell Alicia B.
Published: June 2022

Although amides are one of the most abundant bonds in biology and medicinal chemistry,
methods to prepare them are still limited. To expand on current methods for the formation of amides
bonds, organocatalysts (thiourea-based) were developed to mediate the conversion of esters to amides.
The reactions proceed in good to moderate yields and tolerate a variety of functional groups. 1
H NMR
titration and computational studies show a strong hydrogen-bonding interaction between the thiourea
catalyst and the ester moiety. This hydrogen-bonding interaction is proposed to be the driving force for
the amidation of esters.
Synthetic PARP-1 Inhibitors Reported During the Last Decade
Authors: Guleria Maneesh , Kumar Pradeep , Thareja Suresh
Published: June 2022

Background:

Cancer is the world's second largest cause of death and is responsible for an estimated 9.6 million mortalities in 2018. Poly-ADP-ribose polymerases (PARPs) are enzymes and family of proteins, involved in many cellular processes, including DNA repair, gene regulation, chromatin remodeling, and apoptosis. The first characterized and best known member of the PARP family is poly(ADP-ribose) polymerase 1 (PARP-1). PARP-1 is a major protein for DNA single-strand breaks in the BER pathway (base excision repair) (SSBs).

Objective:

The objective of this article was to compile synthetic PARP-1 inhibitors reported in the last decade

Methods:

In the present manuscript, bibliographic investigation was carried out by scrutinizing peerreviewed
articles from online/offline databases. The inclusion criteria consisted of the most relevant studies
indicating the relationship between PARP-1 and cancer in textbooks/edited books and peer-reviewed
papers from scientific databases, like SCOPUS, PUBMED, NISCAIR, and Google Scholar since 2010 to
2020. Only the studies published in English language were searched/considered. The exclusion criteria
consisted of the studies on other PARP isoforms than PARP-1. The studies thus obtained were classified
according to the heterocyclic moieties, year of publication, etc. The data compiled in this article is a systematic
review of the reported studies.

Results:

The literature reports indicated that a number of PARP-1 inhibitors reported have IC50 value in nanomolar concentration.

Conclusion:

PARP-1 is an essential target for anti-cancer drug discovery. Further, research for more effective and safe PARP-1 inhibitors is carried out and we may discover some novel PARP-1 inhibitors in the near future.
Evaluation of CT Scan Diagnostic Value in the Novel Coronavirus Disease
and Presenting a Corona CT Severity Index
Authors: Taheri Abdolmajid , Asadi-Samani Majid , Dezaki Ebrahim Saedi , Kheiri Soleiman , Taheri Elham
Published: June 2022

Background:

Several diagnostic methods have been proposed and evaluated for the COVID-19 disease. However, the published studies have reported different diagnostic values for these methods.

Aims:

The present study aimed to evaluate the diagnostic performance and accuracy of CT in the novel corona virus disease (COVID-19) and to develop and present a Corona CT severity index.

Methods:

The CT diagnostic performance was measured based on sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy, and RT-PCR was regarded as a standard. Patients’ CT reports were evaluated by a radiologist, and scoring and calculating of the CT severity index were performed.

Results:

Of 208 patients, 82 showed positive and 126 showed negative RT-PCR results with a positive frequency of 39.4% (95% CI, 32.7-46.4). The chest CT scan related to 136 patients indicated COVID-19, whereas their initial RT-PCR assays of 56 patients were negative. Considering RT-PCR results as reference standard, the sensitivity, specificity, and accuracy of chest CT to indicate COVID-19 infection was 100%, 55.6% (95% CI 46.4-64.4%), and 72.8% (95% CI 66.2-78.8%), respectively. The severity of pulmonary involvement was assigned with different grades. For 60.7% of patients with severity grades of 2 to 6, who showed the involvement of at least one lung lobe in CT, PCR retrieved negative results.

Conclusion:

CT scan represents an appropriate sensitivity as well as a consistently higher specificity to diagnose COVID-19 pneumonia than PCR. It can be regarded as a primary tool to detect the current COVID-19 in epidemic regions.
A Rare Case of Extrauterine Endometrial Stromal Sarcoma Arising from
Deep Pelvic Endometriosis: Role of Multidisciplinary Team Meeting
Authors: Long Xueying , Pei Yigang , Masokano Ismail Bilal , Zhu Xin , Lin Wei , He Siting , Liu Hui
Published: June 2022

Introduction:

Extrauterine endometrial stromal sarcoma (EESS) arising from Deep pelvic
endometriosis (DPE) has a poor life quality and is difficult to diagnose pre-operatively. However, the
patient’s quality of life can be improved when it is diagnosed precisely and managed successfully.

Case report:

A 35‑year‑old woman presented to our hospital with a 3-month history of hematochezia
and anal pain. Initially, she was misdiagnosed as a rectal stromal tumor and then precisely diagnosed
as having EESS from DPE following several multidisciplinary team (MDT) meetings. The lesion was
shrunk by gonadotrophin-releasing hormone agonist (GnRH-α) treatment and then resected with minimal
trauma.

Conclusions:

MDT is crucial in the treatment of the patient. It can promote individualized treatment
and improve patient’s quality of life.
Elemicin-rich Cymbopogon khasianus (Hack) Stapf (ex Bor) Essential Oil:
Pharmacological Effects, Toxicological Investigation, and Compositional
Analysis
Authors: Gogoi Roktim , Begum Twahira , Sarma Neelav , Pandey Sudin Kumar , Bhandari Sangeeta , Saikia Samarjit , Tamang Raghu , Saikia Raktim Jyoti , Lal Mohan
Published: June 2022

Background:

Cymbopogon khasianus is a widely used industrial and pharmacologically important aromatic grass species.

Objective:

The present investigation was designed to study and compare the elemicin rich Cymbopogon khasianus essential oil (EREO) and its pharmacological effects, genotoxicity with pure compound elemicin

Materials and Methods:

Chemical composition, identification was performed using GC/MS and NMR techniques. 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), reducing power assay for antioxidant; albumin denaturation, protease inhibitor for anti-inflammatory; acetylcholinesterase (AChE) for anti-cholinesterase; amylase inhibitory for anti-diabetic; tyrosine inhibitory for skin whitening; disc diffusion and minimum inhibitory concentration assay for antimicrobial, and Allium cepa assay for genotoxicity were used.

Results:

GC/MS analysis identified 38 compounds; among them elemicin 72.34%, D-limonene 3.81%; methyl eugenol 3.34% were the major compounds. A significant amount of antioxidant activity IC50 31.38 µg/mL; anti-inflammatory activity (protein denaturation assay) IC50 16.77 µg/mL; protease inihibitor assay IC50 51.08 µg/mL; anticholinesterase IC50 12.095 µg/mL; antidiabetic activity IC50 17.36 µg/mL; and anti-tyrosinase activity IC50 17.69 µg/mL were reported. Antimicrobial activity analysis against 13 microbial strains revealed negative effect. Genotoxicity study using Allium cepa assay revealed negative toxicity of EREO with aberration percentage of 04.30% and pure elemicin 05.30% which was very low in comparison to ethyl-methanesulfonate (EMS) 13.90%.

Conclusion:

To the best of our knowledge this is the first scientific evaluation of novel elemicin rich EREO pharmacological properties and to compare with pure compound elemicin. Together, it can be stated that EREO possesses antioxidant, anti-inflammatory, anti-cholinesterase activities way better than pure compound elemicin as well as standard drugs used.
Novel bis-amide-based bis-thiazoles as Anti-colorectal Cancer Agents Through Bcl-2
Inhibition: Synthesis, In Vitro, and In Vivo studies
Authors: Dawood Kamal M. , Raslan Mohamed A. , Abbas Ashraf A. , Mohamed Belal E. , Nafie Mohamed S.
Published: June 2022

Background:

Some heterocycles having bisamide linkage are receiving much interest due to their remarkable
biological potencies and they are naturally occurring. Some bisamides and thiazole derivatives were found to inhibit
the protein levels of Bcl-2 significantly. This prompted us to synthesize new bis(heterocyclic) derivatives having
bisamide function to explore their anti-cancer activities.

Method:

Novel bis-amide-based bis-thiazoles and thiadiazoles were synthesized by reaction of a new bisthiosemicarbazone
with a variety of hydrazonoyl chlorides, a-chloroacetylacetone and haloacetic acid derivatives. Most
of the synthesized derivatives were tested for colorectal (HCT-116) and breast (MCF-7) cell lines using the MTT assay,
with the apoptotic investigation through flow cytometric and RT-PCR analyses.

Results:

Some derivatives were found to be highly cytotoxic against HCT-116 cells with an IC50 range of (10.44-13.76
μM) compared to 5-fluorouracil (5-FU) (IC50 = 11.78 μM). One product significantly stimulated apoptotic colorectal
cancer cell death by 27.24-fold (50.13% compared to control 1.84%) by arresting the cell cycle at the G2/M phase. The
obtained results revealed that compound 7f was more cytotoxic against HCT-116 cells than 5-FU. Compound 7f
remarkably enhanced apoptotic colorectal cancer cell death and upregulated the propapoptotic genes (P53, BAX and
Capases-3,-8,-9) and downregulated the anti-apoptotic gene, B-cell lymphoma 2 (Bcl-2). In vivo study exhibited that
7f-treatment caused tumor inhibition ratio (TIR%) of 50.45% compared to 54.86% in the 5-FU treatment, with a
significant reduction in tumor mass and volume. The anti-tumor activity of compound 7f was accompanied by
ameliorated hematological and biochemical analyses, histopathological improvement in treated liver tissues, and the
immunohistochemical staining revealed Bcl-2 inhibition in agreement with the in vitro results.

Conclusion:

Compound 7f is an interesting candidate for further development as a chemotherapeutic anti-cancer agent.
İnmeli Bireylerin Fonksiyonel Durumlarının Bakım Veren Ağrısı Üzerine Etkisi
Authors: DURAY Mehmet , YAŞAR Pınar
Published: June 2022

Amaç: İnme sonrası meydana gelen fonksiyonel yetersizlikler bireylerin başkalarına bağımlı hale gelmelerine neden olmaktadır. Fonksiyonel düzeyi düşük inmeli bireylere bakım veren kişilerin maruz kaldıkları fiziksel yüklenmeye bağlı olarak kas iskelet sistemi problemlerine açık hale geldiği bilinmektedir. Bu çalışmanın amacı inmeli bireylerin fonksiyonel durumlarının bu bireylere bakım verenlerin kas iskelet sistemi ağrıları üzerine etkisini incelemektir. Yöntem: Çalışmaya en az 8 haftadır klinik durumu stabil olan 45 inmeli birey ve en az 8 haftadır bu bireylere bakım sağlayan 45 bakım veren katılımcı dahil edildi. Akut ağrısı olan ve ücretli bakım sağlayan kişiler çalışma dışında tutuldu. Hemiplejik/hemiparetik bireylerin fonksiyonel durumlarını belirlemek için Modifiye Rankin Skalası (MRS) uygulandı. Bakım veren bireylerin kas iskelet sistemi ağrısını değerlendirmek için Cornell Kas İskelet Sistemi Rahatsızlık Skalası kullanıldı. Ağrı şiddeti Görsel Analog Skalası (GAS) ile belirlendi. Değerlendirme sonucuna göre bakım verenler, bakım verdikleri inmeli bireylerin fonksiyonel seviyesine göre iki gruba ayrılarak gruplar arası kas iskelet sistemi ağrısı karşılaştırması yapıldı. Bulgular: Grupların sosyodemografik özellikleri bakımından benzer olduğu görüldü (p>0,05). Fonksiyonel seviyesi düşük olan grubun bakım verenlerinde bel ağrısı şiddet ve frekansının diğer vücut bölgelerinden daha yüksek olduğu tespit edildi (p<0,05). İstirahat ve aktivite sırasındaki bel ağrısı GAS değeri fonksiyonel düzeyi düşük olan grupta anlamlı düzeyde yüksek olduğu bulundu (p<0,05). Sonuç: İnmeli bireylerin fonksiyonel durumları, bakıma duyulan ihtiyacı değiştirmektedir. Fonksiyonel düzeyin düşük olması bakım verenlerin kas iskelet sistemi yüklenmelerini artırmaktadır. Bu nedenle, fonksiyonel düzeyi düşük olan inmeli bireylere bakım verenlerin sahip olduğu özellikle omurgaya yönelik semptomların daha titiz bir şekilde ele alınması gerekmektedir.
Análisis del diseño e implementación de un sistema inteligente para el control de la energía en usos residenciales
Authors: David Campo Wilfer Andrés , Agudelo Arboleda Andrés , Arley Salazar Kristian , García Arango David Alberto
Published: June 2022

The present work is focused on the rationalization of electrical energy, as well as an alternative that improves security systems in homes, with this project it is intended to create a system that is not very complex in its management focused on savings. Basically, technological innovations have always been applied and used in homes. Its incorporation has contributed to change from family relationships to the structure of the city.Recently home automation, or the use and adoption of newinformation and communication technologies in the home.It is beginning to induce changes in the use and function ofhousing, accentuating the alterations in the perception ofspace-time that are already detected in other instances of daily life. In countries such as the United States, there are figures that around more than 50% of smartphone users have cell phones with Android operating system, the operating system that follows on the list is iPhone iOS, with 15%, showing a high trend by devices with the operating system provided by Google.
Use of Random Domain Intercept Technology to Track COVID-19 Vaccination Rates in Real Time Across the United States: Survey Study
Authors: Sargent Rikki H , Laurie Shaelyn , Weakland Leo F , Lavery James V , Salmon Daniel A , Orenstein Walter A , Breiman Robert F
Published: June 2022

Background

Accurate and timely COVID-19 vaccination coverage data are vital for informing targeted, effective messaging and outreach and identifying barriers to equitable health service access. However, gathering vaccination rate data is challenging, and efforts often result in information that is either limited in scope (eg, limited to administrative data) or delayed (impeding the ability to rapidly respond). The evaluation of innovative technologies and approaches that can assist in addressing these limitations globally are needed.

Objective

The objective of this survey study was to assess the validity of Random Domain Intercept Technology (RDIT; RIWI Corp) for tracking self-reported vaccination rates in real time at the US national and state levels. RDIT—a form of online intercept sampling—has the potential to address the limitations of current vaccination tracking systems by allowing for the measurement of additional data (eg, attitudinal data) and real-time, rapid data collection anywhere there is web access.

Methods

We used RDIT from June 30 to July 26, 2021, to reach a broad sample of US adult (aged ≥18 years) web users and asked questions related to COVID-19 vaccination. Self-reported vaccination status was used as the focus of this validation exercise. National- and state-level RDIT-based vaccination rates were compared to Centers for Disease Control and Prevention (CDC)–reported national and state vaccination rates. Johns Hopkins University’s and Emory University’s institutional review boards designated this project as public health practice to inform message development (not human subjects research).

Results

By using RDIT, 63,853 adult web users reported their vaccination status (6.2% of the entire 1,026,850 American web-using population that was exposed to the survey). At the national level, the RDIT-based estimate of adult COVID-19 vaccine coverage was slightly higher (44,524/63,853, 69.7%; 95% CI 69.4%-70.1%) than the CDC-reported estimate (67.9%) on July 15, 2021 (ie, midway through data collection; t63,852=10.06; P<.001). The RDIT-based and CDC-reported state-level estimates were strongly and positively correlated (r=0.90; P<.001). RDIT-based estimates were within 5 percentage points of the CDC’s estimates for 29 states.

Conclusions

This broad-reaching, real-time data stream may provide unique advantages for tracking the use of a range of vaccines and for the timely evaluation of vaccination interventions. Moreover, RDIT could be harnessed to rapidly assess demographic, attitudinal, and behavioral constructs that are not available in administrative data, which could allow for deeper insights into the real-time predictors of vaccine uptake–enabling targeted and timely interventions.
Gastroesophageal reflux disease combined with Oddi sphincter dysfunction: control of health-related quality of life in patients
Authors: Mosiychuk L.M. , Demeshkina L.V. , Zigalo E.V.
Published: June 2022

Background. Due to the need to assess the impact of comorbid pathology (GERD and Oddi sphincter dysfunction), it is not possible to use such well-known specific questionnaires as the GERD Health-Related Quality of Life Questionnaire, the Quality of Life in Reflux and Dyspepsia and others. The purpose: to study Health-Related Quality of Life (HRQoL) before and after treatment in patients with GERD, combined with dysfunction of the sphincter of Oddi, using Short Form Health Status Survey (SF-36) and the self-developed specific questionnaire. Materials and methods. 30 patients with comorbid diseases GERD and Oddi’s sphincter dysfunction were studied. SF-36 and the self-developed specific questionnaire were used. Results. The specific questionnaire for patients with gastoesophageal reflux disease combined with Sphincter of Oddi dysfunction was worked out. The evaluation of the questionnaire (patients comprehensiveness of questions, timesuming etc.) was explored. Using SF-36, it was significant improvement of HRQoL for all scales after treatment compared with initial data: physical functioning (PF, (77,1±2,0) versus (71,4±2,2)), role-physical functioning (RP, (52,1±5,0) versus (30,6±2,4)), bodily pain (BP, (65,8±1,2) versus (48,7±2,1)), social functioning (SF, (69,5±2,0) versus (50,8±2,1)), mental health (MH, (68,5±2,1) versus (49,8±1,8)), role emotional (RE, (65,2±4,7) versus (35,8±3,7)), vitality (VT, (63,3±2,1) versus (43,2±2,2)), general health (GH, (58,1±2,4) versus (46,1±1,7) points). All patients had decreased HRQoL due to comorbid GERD and sphincter dysfunction Oddi. Moderate or significant disorders of activity and rhythm of life due to these diseases was revealed, but after treatment there was an improvement in significant HRQoL in all patients, in addition to psycho-emotional perception of their diseases became more positive. Conclusions. All patients had decreased HRQoL due to comorbid GERD and sphincter dysfunction Oddi, and it improved after treatment in most of patients.
ÜNİVERSİTELERİN ÖZEL YETENEK SINAVI İLE ÖĞRENCİ ALAN BÖLÜMLERİNDE GÖREV YAPAN AKADEMİK PERSONELİN SINIRSIZ VE ÇOK YÖNLÜ KARİYER TUTUMLARI
Authors: MAVİBAŞ Muhammet
Published: June 2022

Bu çalışma, üniversitelerin spor bilimleri ile güzel sanatlar fakültelerinde görev yapan akademik personelin sınırsız ve çok yönlü kariyer tutumlarını incelemek amacıyla yapılmıştır. Araştırmaya, üniversitelerin spor bölümlerinden 251, sanat bölümlerinden 172 olmak üzere toplam 423 akademik personelin katılmıştır. Katılımcıların demografik özelliklerini belirlemek için “Kişisel Bilgi Formu”; “Sınırsız Kariyer” ve “Çok Yönlü Kariyer” yönelimlerini araştırmak için Briscoe vd., (2006) tarafından geliştirilen ve Onay ve Ataseven (2010) tarafından Türkçe’ye uyarlanarak geçerlilik ve güvenirlilik çalışması yapılan “Sınırsız ve Çok Yönlü Kariyer Ölçeği” kullanılmıştır. Araştırmanın sonucunda, katılımcıların sınırsız ve çok yönlü kariyer tutumları incelendiğinde, sınırsız kariyer tutumları ile genel çok yönlü kariyer tutumlarının “yüksek” düzeyde olduğu tespit edilmiştir. Üniversitelerin spor ile sanat bölümlerinde görev yapan akademik personel arasında sınırsız ve çok yönlü kariyer tutumlarında anlamlı farklılıklara rastlanmamıştır ve her iki grubunda yüksek düzeyde sınırsız ve çok yönlü kariyer tutumuna sahip oldukları saptanmıştır.
Īpašuma aizsardzība Satversmē
Authors:   Latvijas Universitāte, Rozenfelds Jānis
Published: June 2022

Constitution of Latvia of 1922 consisted of 88 articles. Chapter VIII of the Constitution addressing human rights’ protection became a part of the Constitution only in 1997. Article 105 provides that everyone has the right to own property. Article 105 of Constitution corresponds with the contents of the paragraph 1 of the First Protocol to the European Convention of Human Rights. Protection of the right to ownership as provided by the Constitution is carried out by the Constitutional Court of Latvia. The latter was established in 1996. The current report is based on the analysis of a significant number of judgements which have been handed down by the Constitutional Court in order to establish whether certain acts of legislation are compatible with the Constitution. The effectiveness of such protection could be achieved, if Constitutional court were to scrutinise each contested norm against the Constitution as a whole.
Atsevišķi galvojuma institūta aspekti profesora Aleksandra Būmaņa un Senāta judikatūras atziņās
Authors:   Latvijas Universitāte, Kalniņš Erlens
Published: June 2022

The article considers certain aspects of the institute of suretyship, reflecting the insights into the relevant issues that can be found in the dissertation “Suretyship in Civil Law” by Professor Aleksandrs Būmanis (1881–1937), defended in 1933, and expressed in the recent case law of the Senate. Although the final conclusions (leading theses) of A. Būmanis and the Senate coincide in all aspects discussed in this article, not all of these conclusions have been supported by the same arguments. Therefore, the article explores the differences or similarities in the reasoning used by A. Būmanis and the case law of Senate in order to support the above-mentioned final conclusions.
Tiešā prasība apdrošināšanas līgumtiesībās un tās regulējuma pilnveides nepieciešamība Latvijā
Authors:   Latvijas Universitāte, Mantrovs Vadims
Published: June 2022

The present article deals with direct claim in insurance contract law in Latvia in conjuncture with a discussion of necessity for its modernization. At the beginning, the article provides review of direct claim in Latvian legal environment by analysing its aim and character. Furthermore, the article analyses regulation of direct claim in Latvian civil liability insurance law, particularly Article 53 of theLatvian Insurance Contract Law, in conjuncture with existing Latvian court practice by providing insight in the perception of Latvian courts in respect of application of this regulation. Likewise, this discussion is carried out closely with analysis of regulation of direct claim in other European countries, especially other Baltic states. The article proceeds with characterising modernization of Latvian civil liability insurance regulation on direct claim. Particularly, the author of the article argues that direct claim should be envisaged in Latvia at least in compulsory insurance by following the modern approach and an example of other European countries including the Baltic states. The article finishes with the conclusion summarising the discussion reflected in the article and emphasising the legislative proposal to express Article 53 of the Latvian Insurance Contract Law in a new wording envisaging direct claim at least in compulsory insurance cases.
Prasījumu tiesību cesijas izpratne un ar to saistītā problemātika
Authors:   Latvijas Universitāte, Brants Edijs
Published: June 2022

In this article, the author analyses a number of issues related to the understanding of cession of the right to claim. Firstly, the author analyses the prevailing view in Latvian legal doctrine and case law that cession transfers only the cedents’ rights to cessionary, but not the cedents’ obligations, in which respect the author provides a critique of this approach. Secondly, the author discusses the question of the permissibility of cession of non-monetary claims, noting that typically in practice cession serves monetary claims. Thirdly, the author addresses the issue of the legal consequences in cases where a contractual prohibition on assignment is breached or where the cedent alienates the same claim more than once. Fourthly, as the final issue in this article, the author explores the aspect of assignment of accessory claims.
Personas izdarīts noziedzīgs nodarījums un sodāmība kā Latvijas Republikas Satversmē paredzēto tiesību izvēlēties nodarbošanos un darbavietu ierobežojums
Authors:   Latvijas Universitāte, Vīnkalna Evija
Published: June 2022

The first sentence of the Section 106 of the Constitution of the Republic of Latvia (Constitution) states that “everyone has the right to freely choose their employment and workplace according to their abilities and qualifications”. These rights are not absolute, the Section 116 of the Constitution provides for possibility of restrictions “in circumstances provided for by law in order to protect the rights of other people, the democratic structure of the State, and public safety, welfare and morals”. The aim of the article is to discuss the legal restrictions on the choice of employment and workplace, their assessment in connection with a criminal offence committed by a person and criminal record.
Satversmes 105. pantā garantēto tiesību aizsardzības efektivitāte tiesā pirmstiesas kriminālprocesa laikā
Authors:   Latvijas Universitāte, Kūtris Gunārs
Published: June 2022

Article 105 of the Constitution guarantees the protection of human rights to property. A criminal offence may be directed at the victim’s property and therefore actions must be taken in criminal proceedings to ensure the protection of the victim’s rights. In carrying out this task, the right of the bona fide owner may be infringed. The article analyses the situation, identifies problems and offers solutions to them. The other circle of persons whose rights to property may be limited during criminal proceedings can be the affected owner of the property – the person whose property may be arrested or confiscated. The article offers a proposition aimed at more effective protection of these rights.
Autonomā interpretācija Briseles I bis regulā
Authors:   Latvijas Universitāte, Kačevska Inga
Published: June 2022

This contribution discusses the autonomous interpretation of concepts in the Brussels I bis regulation. It explains a meaning of “autonomous interpretation” and gives guidance for establishment of autonomous concepts in the Regulation. Most particularly, this article deals with the autonomous meanings of “sale of goods”, “provision of services”, “object rights in rem in immovable property or tenancies” and difficulties of application of those concepts in the courts of Latvia.
Judikatūras maiņa, tiesiskā noteiktība un tiesiskās paļāvības princips
Authors:   Latvijas Universitāte, Krūkle Ginta
Published: June 2022

The article is dedicated to the evolution of the judge-made-law by way of overruling as an unavoidable phenomenon of administration of justice, as well as to the theoretical and practical risks associated with the overruling. The author identifies problematic aspects of the concept of overruling, and analyses each of them in the context of the need for the development of judge-made-law as part of a dynamic legal system. Thesis of the judge-made-law are being recognised as legal norms formulated by judges, and, as such, these norms not only may, but should follow the development of the legal system. Weighting and balancing of the legal certainty and the principle of legitimate expectations on one side against fair trial and requirement of justice and rule of law on the other side gives the answer to the question whether to overrule or not in the specific case at hand.
Faktiskās rīcības jēdziens Latvijā un Vācijā
Authors:   Latvijas Universitāte, Kovaļevska Anita
Published: June 2022

The concept of real action (Realakt – in German) is well known in both Latvia and Germany. In both countries, real action is contrasted with those acts of public administration that produce legal effects, thus explaining the distinction between real action and administrative acts, regulatory acts and contracts. In Germany, however, the concept of real action is broader and actually covers all activities of public administration, which do not produce legal effects. Consequently, public administration’s activities (actions) in the field of private law, activities (actions) aimed at the execution of an administrative act, simple administrative activities (actions), internal public administration activities (actions) and procedural activities (actions) are also covered by the concept of real action.
Pieteikuma tiesības administratīvajā tiesā un varas dalīšanas princips
Authors:   Latvijas Universitāte, Bērtaite-Pudāne Inga
Published: June 2022

Standing before the administrative court and the principle of separation of powers is a relatively rarely discussed topic in the continental legal tradition. This article focuses on the said topic in the Latvian legal system. The possible impact of the individual legal standing, as well as of actio popularis in environmental cases, on the principle of separation of powers is analysed separately.
PENINGKATAN PENGETAHUAN DAN SIKAP SISWA SMK N 2 KOTA JAMBI DALAM KESELAMATAN BERKENDARA (SAFETY RIDING)
Authors: Halim Rd. , Syukri Muhammad
Published: June 2022

Motor vehicle accidents are multifactorial (human factors, vehicles, and the physical environment).The high percentage of young riders in motorcycle accidents is a serious public health problem. The purpose of this counseling activity is to increase knowledge and attitudes in safety riding. The target of this service activity was 21 students of SMK N 2 Jambi City who were selected purposively. Students are given understanding related to safety riding and then followed by a discussion. Before being given the material, students are asked to fill out a pre-test form to measure knowledge and attitudes, then another measurement was taken after the discussion session in the form of a post-test to find out differences in attitude knowledge before and after counseling. Data analysis used the Wilcoxon test and paired sample t-test. The analysis showed that there were differences in knowledge (p-value = 0.005) and attitudes (p-value = 0.001) before and after counseling. Counseling that has a positive impact so that there is an increase in the knowledge and attitudes of students of SMKN 2 Jambi City.
PENYULUHAN KESEHATAN TENTANG GIZI SEIMBANG DI POSYANDU BALITA KINASIH RW 29 WILAYAH KELURAHAN KADIPIRO SURAKARTA
Authors: Pratiwi Erinda Nur , Nurjanah Siti , Murharyati Atiek
Published: June 2022

A health problem in Indonesia is the death of children under five years of age (toddlers). Based on the results of Basic Health Research, the prevalence of malnutrition under 5 years of age in Indonesia is 17.9% (3.7 million children under five), as many as 6800 children under five in East Java experience malnutrition, 25% of which is caused by malnutrition intake. Malnutrition status in toddlers can have an effect that greatly inhibits physical, mental and thinking skills which in turn will reduce work productivity. Balanced food at this age needs to be implemented because it will affect the quality at adulthood to advanced age so that community service is expected to improve the health status of toddlers. The goal of community service in the form of counseling on balanced nutrition is that after receiving the counseling, it is hoped that mothers with toddlers are able to instill good and correct eating habits in their children regarding balanced nutrition according to the needs for optimal child development, maintaining and increasing endurance. child against disease. The benefits of community service to increase knowledge, especially about balanced nutrition for toddlers according to the needs for optimal child growth and development so as to maintain and increase the child's resistance to disease. This community service method includes lectures, questions and answers and leaflet media. The results of the implementation of community service regarding balanced nutrition for toddlers show that toddlers' mothers understand better about balanced nutrition in toddlers with an average value of knowledge about balanced nutrition in toddlers with a percentage of 75%. The conclusion from this community service is that it is important for mothers under five to understand balanced nutrition in toddlers because it can improve the healthstatus of toddlers.
Optimalisasi Individual Effort, Organizational Effort dan Environment Effort Pemuda Karang Taruna Dalam Meningkatkan Daya Tanggap (Responsiveness) Kondisi Darurat Wabah COVID-19
Authors: Murharyati Atiek , Sulisetyowati Dwi , Pratiwi Erinda Nur , Nurjanah Siti
Published: June 2022

Taruna coral organization has an important role to face the Covid  19 outbreak, because it has good resilience and a reliable way of thinking,so that it can be done optimization of taruna coral organization in keeping the spread of Covid  19 is not more widespread. Based on this, the youth of taruna coral needs strengthening of the organization so that it will increase the powerof the ladder p(responsiveness)  smart youth. The purpose of community service is to strengthen the organization of taruna coral so that it can become an organization that has high responsiveness to the environmental situation due to Covid through the strengthening of  individual efforts, organizational efforts and environment efforts. Some things that need to be strengthened are  individual effort, organizational effort and environment effort. The method is done by educating young people in the form of lectures and mentoring  activities in the face of the Covid 19 pandemic outbreak. The results were realized that after the education of 100% members of taruna coral realize and know the importance of strengthening the organization through strengthening  individual effort, organizational effort and environment effort. And after mentoring activities in the form of social service, 100% of taruna coral members are able to do activities as a form of responsiveness  to the occurrence of the covid 19 outbreak, namely by the form of social service activities of distribution of foodstuffs and Brochures covid 19 to citizens. The conclusion is that taruna coral organizations can run programs by fostering and strengthening  individual efforts, organizational efforts and environment efforts  so as to have responsiveness   to the environmental situation due to Covid 19.
Perlindungan Hukum Terhadap Anak Yang Berada Di Wilayah Perang Menurut Konvensi Jenewa 1949 Dengan Protokol Tambahan 1977
Authors: Amini Intan , Perbrianto Dony Yusra
Published: June 2022

Artikel ini membahas bagaimana perlindungan terhadap anak-anak yang berada di wilayah konflik bersenjata. Perlindungan anak telah diatur pada Konvensi Jenewa 1949, Protokol Tambahan 1977, International Convention on The Rights of  Childs 1989, Optional Protocol on Involvent of Children in Armed Conflict 2000. Namun, para pihak yang berkonflik masih melanggar prinsip pembedaan, prinsip pembatasan, prinsip keseimbangan, dan prinsip perlindungan yang berlaku dalam hukum humaniter internasional.  Padahal, Hukum Humaniter  melarang penduduk sipil dijadikan sebagai objek kekerasan dan wajib diberikan  perlindungan  dari segala hal yang berkaitan dengan peperangan. Sedangkan kombatan dapat dijadikan objek kekerasan saat berperang tetapi tetap wajib  diberikan perlindungan ketika menjadi tawanan perang. Sebagai bentuk tanggung jawab negara, maka sanksi pidana dan ganti rugi perlu diterapkan demi menjamin kepastian hukum dan memberikan keadilan bagi para pihak yang menjadi korban menurut hukum humaniter.
Legitimasi Hukuman Mati: Perlukah Mandatory Consular Notification Antar Negara?
Authors: Fatriani Lendra , Sipahutar Bernard
Published: June 2022

Artikel ini mempertanyakan bagaimana praktik Mandatory Consular Notification yang diterapkan oleh Kerajaan Arab Saudi terhadap Indonesia dalam menyelamatkan tenaga kerja yang dijatuhi hukuman mati. Mandatory Consular Notification adalah hak untuk memperoleh informasi dan akses terkait perwakilan negara atas warga negaranya serta hak warga negara atas staf perwakilan negara. Ini merupakan pedoman utama dalam tata laksana hubungan internasional yang telah diatur di Pasal 36 dan Pasal 37 Konvensi Wina 1963. Dalam pelaksanaannya, Kerajaan Arab Saudi tidak melakukan Mandatory Consular Notification sesuai ketentuan yang berlaku. Oleh karena itu Indonesia perlu memastikan upaya-upaya perlindungan hukum  terhadap tenaga kerjanya dengan cara melakukan Memorandum of Understanding dengan Kerajaan Arab Saudi. Selain itu, Indonesia juga perlu mengupayakan langkah hukum lain khususnya dalam bentuk perjanjian agar tercipta kepastian hukum diantara negara pihak.
EFFECT TWO ZERO DISPERSION WAVELENGTHS AND RAMAN SCATTERING IN THE THIRD-ORDER SOLITON OF SOLID CORE PHOTONIC CRYSTAL FIBERS TO PRODUCE SUPERCONTINUUM GENERATION
Authors: Altaie Mohammed
Published: June 2022

Photonic crystal fibers (PCFs) which consist of dielectric materials are a don't ever and an ever field in more modern application. The Split-Step Fourier method (SSFM) was used in this work to create a fiber photonic crystal, which was suggested and validated using a Matlab software .The impact of two -zero- dispersion on the Soliton in solid core photonic crystal fibers has been studied by investigating the interplay between Raman effect and second- order- dispersion. It has been discovered that the proposed photonic crystal fibers two –zero- dispersion wavelengths (TZDW) can be used to effectively tailor the properties of third order soliton. Many current applications, including medical and industrial, rely on spectral expansion. In addition, soliton has an important role in modern communication systems.
PENGELOLAAN FILANTROPI ISLAM DI TENGAH PANDEMI COVID-19 (STUDI PADA KOMUNITAS KURIR SEDEKAH)
Authors: Efendi Mansur
Published: June 2022

Â Covid-19 pandemic which happened to most of countries have been heavily affected many sectors, especially economy. Social distancing policy in Indonesia implicated on businesses activities degression. Many companies have to do a layoff policy. Another issues also appeared when positive patients must be quarantined. Economic issues that appear during pandemics triggered many philanthropy movement in Indonesia to be founded, one of them is Komunitas Kurir Sedekah (Charity Courier Community). The appearance of Komunitas Kurir Sedekah added diversity of Islamic philanthropy movement in Indonesia. Their crowd fundind and recipients targeting program is practical, efficient and directly involving all members. With this approach, all members of community had strong sense of belonging. Meanwhile, funds distribution directed to overcome to short term and temporary humanity issues. At least, the appearance of Komunitas Kurir Sedekah capable to overcome government's temporary program's problematics. Furthermore, this community can raise community awareness to do charity during pandemics.Â Â Pandemi Covid-19 yang terjadi hampir di semua negara, telah memberikan dampak yang cukup berat pada sendi kehidupan, khususnya sektor ekonomi. Demikian halnya dengan Indonesia, kebijakan pembatasan aktivitas bagi masyarakat (social distancing) berimplikasi pada penurunan kegiatan bisnis. Beberapa perusahaan terpaksa melakukan Pemutusan Hubungan Kerja (PHK). Persoalan lain juga nampak pada masyarakat yang dinyatakan positif dan harus dirawat serta dikarantina. Persoalan ekonomi yang muncul sebagai akibat Pandemi Covid-19, merangsang lahirnya gerakan filantropi di Indonesia, salah satunya adalah Komunitas Kurir Sedekah. Keberadaan Komunitas Kurir Sedekah menambah keragaman gerakan filantropi Islam di Indonesia. Sasaran penerima program dan penghimpunan dana dilakukan secara praktis, cepat dan melibatkan langsung anggota. Dengan pendekatan seperti ini, maka rasa kepemilikan (sense of belonging) anggota terhadap komunitas akan semakin kuat. Sedangkan penyaluran dana diarahkan pada persoalan kemanusiaan yang bersifat jangka pendek. Hadirnya Komunitas Kurir Sedekah setidaknya mampu menjawab problematika program pemerintah yang sifatnya temporer. Lebih jauh, keberadaannya juga mampu meningkatkan kesadaran masyarakat untuk tetap berbagi di tengah pandemi.
ANALISIS STRATEGI FUNDRAISING ORGANISASI PENGELOLA ZAKAT DI ERA DIGITALISASI
Authors: Yuliar Ade
Published: June 2022

Zakat potential in Indonesia is very large, but the potential has not been explored optimally. One of the challenges is how zakat institutions create innovative strategies of collecting zakat in accordance with the current millennial era. This study aims to analyze zakat fundrasing models that have been done by zakat institutions and also attempt to propose solutions to optimize zakat funding in the digital era. The results of the research formulate that digital era funding strategy must be in line with the revolutionary spirit of industry 4.0 characterized by digital-based. So far the fundraising strategy is not yet new, that is still conservative for example: not yet make the website become based on android, so website more accessible. Zakat institutions also should innovates zakat payment cooperation as online zakat (online payment or e-payment), for example cooperation through fintech and e-commerce. Suggestions and conclusions that all zakat institutions have similarities, no new strategy and zakat institutions should innovate in strategy.Â Potensi zakat di Indonesia sangat besar, namun potensi tersebut belum tergarap secara maksimal. Salah satu tantangannya adalah bagaimana lembaga zakat menciptakan strategi inovatif dalam menghimpun zakat sesuai dengan era milenial saat ini. Penelitian ini bertujuan untuk menganalisis model-model fundrasing zakat yang telah dilakukan oleh lembaga zakat dan juga berupaya memberikan solusi untuk mengoptimalkan pendanaan zakat di era digital. Hasil penelitian merumuskan bahwa strategi pendanaan era digital harus sejalan dengan semangat revolusioner industri 4.0 yang bercirikan berbasis digital. Sejauh ini strategi fundraising masih belum baru, yaitu masih konservatif misalnya: belum menjadikan website berbasis android, sehingga website lebih mudah diakses. Lembaga zakat juga harus melakukan inovasi kerjasama pembayaran zakat sebagai zakat online (pembayaran online atau e-payment), misalnya kerjasama melalui fintech dan e-commerce. Saran dan kesimpulan bahwa lembaga zakat memiliki kesamaan,yaitu tidak ada strategi baru dan lembaga zakat harus berinovasi dalam strategi fundraising.
NILAI FILANTROPI: SEBUAH TINJAUAN PELAKSANAAN AKAD QARDHUL HASAN DI MASA PANDEMI
Authors: Murdianto Wahidin
Published: June 2022

BMT Tumang Boyolali is a non-bank Islamic financial institution. Baitul Maal wa Tamwil is an institution that runs two fields, namely business through Tamwil and social through maal. One of the social programs at Baitul Maal at BMT Tumang is an economic empowerment program, namely Pokusma. The main problem raised regarding the implementation of the qardhul hasan contract used in the maal program is reviewed with maqashid shari'ah during the covid-19 pandemic, namely the suitability of the implementation of the contract with existing provisions and the fulfillment of maqashid shari'ah values in the use of the qardhul hasan contract in the field of Maal BMT Tumang Boyolali Center during the covid-19 pandemic. Thus it will be known how the qardhul hasan contract is used in the maal program in the midst of the Covid-19 pandemic. The review of maqashid shari'ah on the implementation of the qardhul hasan contract during the covid-19 pandemic will reveal the extent to which the values of maqashid sharia and maqashid qardh are being fulfilled.
 
BMT Tumang Pusat Boyolali merupakan lembaga keuangan syariah non Bank. Baitul Maal wa Tamwil merupakan lembaga yang menjalankan dua bidang, yakni bisnis melalui tamwil dan sosil melalui maal. Salah satu program sosial pada baitul maal di BMT Tumang adalah program pemberdayaan ekonomi yaitu pokusma. Masalah utama yang diangkat perihal pelaksanaan akad qardhul hasan yang digunakan pada program maal ditinjau dengan maqashid syariah di masa pandemi covid-19 yakni kesesuaian pelaksanaan akad dengan ketentuan yang ada dan pemenuhan nilai-nilai maqashid syariah dalam penggunaan akad qardhul hasan dalam bidang maal BMT Tumang Pusat Boyolali di masa pandemi covid-19. Dengan demikian akan diketahui bagaimana penggunaan akad qardhul hasan pada program maal di tengah pandemi Covid-19. Tinjauan  maqashid syariah terhadap pelaksanaan akad qardhul hasan di masa pandemi covid-19 akan diketahui sejauh mana pemenuhan nilai-nilai maqashid syariah dan maqashid qardh.
Nivolumab for Pediatric Malignant Peritoneal Mesothelioma
Authors: Ortaköylü Melek Yaman , Özdemir Sonay İncesoy , Dinçaslan Handan Ugur , Tacyildiz Nurdan , Ünal Ali Ekrem , Soydal Çiğdem , Fitoz Suat , Unal Emel
Published: June 2022

Mesothelioma is a rare and aggressive tumor originating from the serosal
lining of the pleural, peritoneal and pericardial cavities. There are
very few cases diagnosed with malignant peritoneal mesothelioma reported
in childhood. Thanks to the developments in the field of immunotherapy,
the prognosis of the disease has improved with the addition of the
immune check point inhibitor, an anti-programmed death-1 monoclonal
antibody, nivolumab to the treatment of MPM. In the treatment of our
case who was diagnosed with diffuse malignant peritoneal mesothelioma at
a very early age; cytoreductive surgery, hyperthermic intraperitoneal
chemotherapy, platinum and pemetrexed combination chemotherapy and
nivolumab were used. Our patient, who has been on nivolumab therapy for
14 months and has been followed up for 20 months since her diagnosis, is
still in remission. This case supports the utility of nivolumab in
pediatric MPM.