bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of the Role of Australia and New Zealand in Sustainable Dairy Competition in the Chinese Market after the Dairy Safety Scandals
Authors: Xu Junqian , Wu Yuanyuan
Published: December 2018

After the melamine milk scandal in 2008, China’s global imports of dairy products soared, especially after FTAs had been established with Australia and New Zealand. The dairy products of the two countries have a unique competitive trading advantage in the Chinese market. However, at a time when Chinese consumers are increasingly dependent on imported dairy products, a succession of whey protein scandals affecting New Zealand’s dairy products in 2013 had a negative psychological impact on Chinese importers and consumers, and this even affected the import status of New Zealand dairy imports to the Chinese market. The present paper, based on the United Nations Comtrade Harmonized System, studies the role of Australia and New Zealand in China’s dairy market. It calculates the trade competitiveness index, revealing the relative competitive advantages of Australia and New Zealand, and investigates the impact of the dairy products from these countries on China’s imports from the rest of the world across six dairy sectors in the period 1992–2017. We find that, under the food safety laws, the relative dairy import prices, milk scandals, and Free Trade Agreements, together with the competitive advantages of Australia and New Zealand, had a varied impact on the corresponding Chinese dairy imports across the relevant sectors in the context of China food safety laws after the melamine milk scandal. These findings acknowledge Australia and New Zealand’s competitiveness in the international dairy trade, and also lead to suggestions regarding their competitiveness and sustainable development in the Chinese market.
The Role of Sleep Quality in the Psychological Well-Being of Final Year UndergraduateStudents in China
Authors: Zhai Keyu , Gao Xing , Wang Geng
Published: December 2018

There are increasing numbers of university students in China suffering from poor sleep and psychological well-being problems. In particular, the issues are more severe among the final year undergraduate students, because they are experiencing a transitory period from university life to the workplace. However, extant research has rarely explored sleep quality and psychological well-being of final year university students. To better understand the role of sleep quality in psychological well-being, we examined the association between different sleep quality and mental health. Based on a cross-sectional survey of 2495 full-time final year university students in China, we employed multivariable logistic regression to assess association between sleep quality and psychological well-being by controlling for sociodemographic factors such as age, gender, education, marital or relationship status, household conditions, place of birth, study subjects and etc. According to the research results, we can find strong association between sleep quality and psychological well-being. Having normal sleep quality is associated with lower level of psychological well-being problems. By contrast, poor sleep quality is associated with high level of negative psychological well-being. Poor sleep quality has higher potency than normal sleep quality due to negative bias. Among covariates, age, gender and education have significant effects on psychological well-being.
Depression and Quality of Life among Patients Living with HIV/AIDS in the Era of Universal Treatment Access in Vietnam
Authors: Tran Bach Xuan , Dang Anh Kim , Truong Nu Thi , Ha Giang Hai , Nguyen Huong Lan Thi , Do Ha Ngoc , Nguyen Tuan Quoc , Latkin Carl A. , Ho Cyrus S. H. , Ho Roger C. M.
Published: December 2018

Although antiretroviral treatment (ART) access has been universal in recent years, few studies have examined if this policy contributes to the mental health of the patients. This study assessed depression and its relations with health-related quality of life (HRQOL), which is defined as the status of general well-being, physical, emotional, and psychological, among HIV patients. A cross-sectional study was conducted in 482 patients at five outpatient clinics. Patient Health Questionnaire-9 (PHQ-9) and EuroQol-5 dimensions-5 levels (EQ-5D-5L) were used to assess the severity of depression and HRQOL. About one-fifth of patients reported symptoms of depression. According to the result of a multivariate logistic regression model, patients who had a lower number of CD4 cells at the start of ART, who received ART in the clinic without HIV counseling and testing (HCT) services, who had a physical health problem, and who experienced discrimination were more likely to have depression. Depression was associated with significantly decreased HRQOL. Depression is prevalent and significantly negatively associated with HRQOL of HIV/AIDS patients. We recommend screening for depression and intervening in the lives of depressed individuals with respect to those who start ART late, and we also recommend community-based behavioral change campaigns to reduce HIV discrimination.
The Role of Job Demands–Resources (JDR) between Service Workers’ Emotional Labor and Burnout: New Directions for Labor Policy at Local Government
Authors: Kim Sunhee , Wang Jaesun
Published: December 2018

Recently, research on service workers’ emotional labor has received considerable attention, both in theory and practice. Emotional labor has been reported to cause both stress and burnout in service workers, eventually leading to a decrease in organizational productivity. In this context, there is also a growing interest in identifying ways to reduce such burnout. This study aimed to examine the influence of emotional labor and job demands–resources (JD–R) on service workers’ burnout. Specifically, we analyzed the direct, indirect, and moderating effects of JD–R on burnout. Data were collected from service workers (N = 1517) in public sectors. Results revealed that three dimensions—emotional labor, intensity/variety, and surface acting—increase burnout, whereas deep acting decreases it. Additionally, job demands were found to increase burnout, while job resources decreased it. Among the job demands, customer contact had the greatest positive impact on burnout, followed by role ambiguity and workload, respectively. Among the job resources, self-efficacy and social support had the greatest negative impact on burnout. Finally, customer contact, role ambiguity, job autonomy, and social support were identified as moderators that worsened or buffered the impact of emotional labor on burnout.
Undeserving, Disadvantaged, Disregarded: Three Viewpoints of Charity Food Aid Recipients in Finland
Authors: Salonen Anna Sofia , Ohisalo Maria , Laihiala Tuomo
Published: December 2018

Since the economic recession of the 1990s, Finland has experienced the proliferation of charity food aid as a means of helping people who are afflicted by poverty. However, so far little research has been conducted regarding the food aid recipients. This article gives discursive, demographic, and experiential insights into charity food provision and reception in Finland. Drawing on quantitative survey data, online discussion data related to news published on Finnish newspapers’ web pages, and observation and interviews with food aid recipients, this article sheds new light on Finnish food aid recipients from three perspectives. First, public perceptions about food aid often portray food recipients as dishonourable and responsible for their own poverty. Secondly, the survey data shows that the main reason for people resorting to charity food aid is deep economic disadvantage, and further, that there is an unequal accumulation of disadvantage among the food aid recipients, illustrating internal diversity. Third, observational and interview data show that from the food recipients’ perspective, the food aid system has only a limited ability to answer even their immediate food needs, and for the recipients, food aid venues can become not only socially significant, but also socially demanding and emotionally burdening places.
Sistas Taking a Stand for Breast Cancer Research (STAR) Study: A Community-Based Participatory Genetic Research Study to Enhance Participation and Breast Cancer Equity among African American Women in Memphis, TN
Authors: Smith Alana , Vidal Gregory A. , Pritchard Elizabeth , Blue Ryan , Martin Michelle Y. , Rice LaShanta J. , Brown Gwendolynn , Starlard-Davenport Athena
Published: December 2018

African American women are substantially underrepresented in breast cancer genetic research studies and clinical trials, yet they are more likely to die from breast cancer. Lack of trust in the medical community is a major barrier preventing the successful recruitment of African Americans into research studies. When considering the city of Memphis, TN, where the percentage of African Americans is significantly higher than the national average and it has a high rate of breast cancer mortality inequities among African American women, we evaluated the feasibility of utilizing a community-based participatory (CBPR) approach for recruiting African American women into a breast cancer genetic study, called the Sistas Taking A Stand for Breast Cancer Research (STAR) study. From June 2016 and December 2017, African American women age 18 and above were recruited to provide a 2 mL saliva specimen and complete a health questionnaire. A total of 364 African American women provided a saliva sample and completed the health questionnaire. Greater than 85% agreed to be contacted for future studies. Educational workshops on the importance of participating in cancer genetic research studies, followed by question and answer sessions, were most successful in recruitment. Overall, the participants expressed a strong interest and a willingness to participate in the STAR study. Our findings highlight the importance of implementing a CBPR approach that provides an educational component detailing the importance of participating in cancer genetic research studies and that includes prominent community advocates to build trust within the community.
Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus
Authors: Yin Limin , Gan Xiuhai , Shi Jing , Zan Ningning , Zhang Awei , Ren Xiaoli , Li Miao , Xie Dandan , Hu Deyu , Song Baoan
Published: December 2018

Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent biological activity against plant viruses, especially protective activity. Inspired by these results, the active substructure of pentadienone and quinazoline were spliced to obtain curcumin analogs as potential exogenously induced resistant molecule. Bioassay results showed that compound A13 exhibited excellent protective activity for tobacco to against Tobacco mosaic virus (TMV) at 500 μg/mL, with a value of 70.4 ± 2.6% compared with control treatments, which was better than that of the plant immune activator chitosan oligosaccharide (49.0 ± 5.9%). The protective activity is due to compound A13 inducing tobacco resistance to TMV, which was related to defense-related enzymes, defense-related genes, and photosynthesis. This was confirmed by the up-regulated expression of proteins that mediate stress responses and oxidative phosphorylation.
Butyrate Stimulates Histone H3 Acetylation, 8-Isoprostane Production, RANKL Expression, and Regulated Osteoprotegerin Expression/Secretion in MG-63 Osteoblastic Cells
Authors: Chang Mei-Chi , Chen Yunn-Jy , Lian Yun-Chia , Chang Bei-En , Huang Chih-Chia , Huang Wei-Ling , Pan Yu-Hwa , Jeng Jiiang-Huei
Published: December 2018

Butyric acid as a histone deacetylase (HDAC) inhibitor is produced by a number of periodontal and root canal microorganisms (such as Porphyromonas, Fusobacterium, etc.). Butyric acid may affect the biological activities of periodontal/periapical cells such as osteoblasts, periodontal ligament cells, etc., and thus affect periodontal/periapical tissue destruction and healing. The purposes of this study were to study the toxic effects of butyrate on the matrix and mineralization marker expression in MG-63 osteoblasts. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cellular apoptosis and necrosis were analyzed by propidium iodide/annexin V flow cytometry. The protein and mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) were analyzed by Western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR). OPG, soluble RANKL (sRANKL), 8-isoprostane, pro-collagen I, matrix metalloproteinase-2 (MMP-2), osteonectin (SPARC), osteocalcin and osteopontin (OPN) secretion into culture medium were measured by enzyme-linked immunosorbant assay. Alkaline phosphatase (ALP) activity was checked by ALP staining. Histone H3 acetylation levels were evaluated by immunofluorescent staining (IF) and Western blot. We found that butyrate activated the histone H3 acetylation of MG-63 cells. Exposure of MG-63 cells to butyrate partly decreased cell viability with no marked increase in apoptosis and necrosis. Twenty-four hours of exposure to butyrate stimulated RANKL protein expression, whereas it inhibited OPG protein expression. Butyrate also inhibited the secretion of OPG in MG-63 cells, whereas the sRANKL level was below the detection limit. However, 3 days of exposure to butyrate (1 to 8 mM) or other HDAC inhibitors such as phenylbutyrate, valproic acid and trichostatin stimulated OPG secretion. Butyrate stimulated 8-isoprostane, MMP-2 and OPN secretion, but not procollagen I, or osteocalcin in MG-63 cells. Exposure to butyrate (2–4 mM) for 3 days markedly stimulated osteonectin secretion and ALP activity. In conclusion, higher concentrations of butyric acid generated by periodontal and root canal microorganisms may potentially induce bone destruction and impair bone repair by the alteration of OPG/RANKL expression/secretion, 8-isoprostane, MMP-2 and OPN secretion, and affect cell viability. However, lower concentrations of butyrate (1–4 mM) may stimulate ALP, osteonectin and OPG. These effects are possibly related to increased histone acetylation. These events are important in the pathogenesis and repair of periodontal and periapical destruction.
Interaction of Chrysin and Its Main Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide with Serum Albumin
Authors: Mohos Violetta , Fliszár-Nyúl Eszter , Schilli Gabriella , Hetényi Csaba , Lemli Beáta , Kunsági-Máté Sándor , Bognár Balázs , Poór Miklós
Published: December 2018

Chrysin (5,7-dihydroxyflavone) is a flavonoid aglycone, which is found in nature and in several dietary supplements. During the biotransformation of chrysin, its conjugated metabolites chrysin-7-sulfate (C7S) and chrysin-7-glucuronide (C7G) are formed. Despite the fact that these conjugates appear in the circulation at much higher concentrations than chrysin, their interactions with serum albumin have not been reported. In this study, the complex formation of chrysin, C7S, and C7G with human (HSA) and bovine (BSA) serum albumins was investigated employing fluorescence spectroscopic, ultrafiltration, and modeling studies. Our major observations/conclusions are as follows: (1) Compared to chrysin, C7S binds with a threefold higher affinity to HSA, while C7G binds with a threefold lower affinity; (2) the albumin-binding of chrysin, C7S, and C7G did not show any large species differences regarding HSA and BSA; (3) tested flavonoids likely occupy Sudlow’s Site I in HSA; (4) C7S causes significant displacement of Sudlow’s Site I ligands, exerting an even stronger displacing ability than the parent compound chrysin. Considering the above-listed observations, the high intake of chrysin (e.g., through the consumption of dietary supplements with high chrysin contents) may interfere with the albumin-binding of several drugs, mainly due to the strong interaction of C7S with HSA.
miRNAmotif—A Tool for the Prediction of Pre-miRNA–Protein Interactions
Authors: Urbanek-Trzeciak Martyna O. , Jaworska Edyta , Krzyzosiak Wlodzimierz J.
Published: December 2018

MicroRNAs (miRNAs) are short, non-coding post-transcriptional gene regulators. In mammalian cells, mature miRNAs are produced from primary precursors (pri-miRNAs) using canonical protein machinery, which includes Drosha/DGCR8 and Dicer, or the non-canonical mirtron pathway. In plant cells, mature miRNAs are excised from pri-miRNAs by the DICER-LIKE1 (DCL1) protein complex. The involvement of multiple regulatory proteins that bind directly to distinct miRNA precursors in a sequence- or structure-dependent manner adds to the complexity of the miRNA maturation process. Here, we present a web server that enables searches for miRNA precursors that can be recognized by diverse RNA-binding proteins based on known sequence motifs to facilitate the identification of other proteins involved in miRNA biogenesis. The database used by the web server contains known human, murine, and Arabidopsis thaliana pre-miRNAs. The web server can also be used to predict new RNA-binding protein motifs based on a list of user-provided sequences. We show examples of miRNAmotif applications, presenting precursors that contain motifs recognized by Lin28, MCPIP1, and DGCR8 and predicting motifs within pre-miRNA precursors that are recognized by two DEAD-box helicases—DDX1 and DDX17. miRNAmotif is released as an open-source software under the MIT License. The code is available at GitHub (www.github.com/martynaut/mirnamotif). The webserver is freely available at http://mirnamotif.ibch.poznan.pl.
Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-κB Phosphorylation
Authors: Yang Chien-Chung , Lin Chih-Chung , Hsiao Li-Der , Yang Chuen-Mao
Published: December 2018

Galangin, a member of the flavonol compounds of the flavonoids, could exert anti-inflammatory effects in various cell types. It has been used for the treatment of arthritis, airway inflammation, stroke, and cognitive impairment. Thrombin, one of the regulators of matrix metalloproteinase (MMPs), has been known as a vital factor of physiological and pathological processes, including cell migration, the blood–brain barrier breakdown, brain edema formation, neuroinflammation, and neuronal death. MMP-9 especially may contribute to neurodegenerative diseases. However, the effect of galangin in combating thrombin-induced MMP-9 expression is not well understood in neurons. Therefore, we attempted to explore the molecular mechanisms by which galangin inhibited MMP-9 expression and cell migration induced by thrombin in SK-N-SH cells (a human neuroblastoma cell line). Gelatin zymography, western blot, real-time PCR, and cell migration assay were used to elucidate the inhibitory effects of galangin on the thrmbin-mediated responses. The results showed that galangin markedly attenuated the thrombin-stimulated phosphorylation of proto-oncogene tyrosine-protein kinase (c-Src), proline-rich tyrosine kinase 2 (Pyk2), protein kinase C (PKC)α/β/δ, protein kinase B (Akt), mammalian target of rapamycin (mTOR), p42/p44 mitogen-activated protein kinase (MAPK), Jun amino-terminal kinases (JNK)1/2, p38 MAPK, forkhead box protein O1 (FoxO1), p65, and c-Jun and suppressed MMP-9 expression and cell migration in SK-N-SH cells. Our results concluded that galangin blocked the thrombin-induced MMP-9 expression in SK-N-SH cells via inhibiting c-Src, Pyk2, PKCα/βII/δ, Akt, mTOR, p42/p44 MAPK, JNK1/2, p38 MAPK, FoxO1, c-Jun, and p65 phosphorylation and ultimately attenuated cell migration. Therefore, galangin may be a potential candidate for the management of brain inflammatory diseases.
Searching for the Novel Specific Predictors of Prostate Cancer in Urine: The Analysis of 84 miRNA Expression
Authors: Lekchnov Evgeniy A. , Amelina Evgeniya V. , Bryzgunova Olga E. , Zaporozhchenko Ivan A. , Konoshenko Mariya Yu. , Yarmoschuk Sergey V. , Murashov Ivan S. , Pashkovskaya Oxana A. , Gorizkii Anton M. , Zheravin Aleksandr A. , Laktionov Pavel P.
Published: December 2018

The aim of this study was to investigate miRNA profiles of clarified urine supernatant and combined urine vesicle fractions of healthy donors and patients with benign prostatic hyperplasia and prostate cancer (PCa). The comparative analysis of miRNA expression was conducted with a custom miRCURY LNA miRNA qPCR panel. Significant combinations of miRNA pairs were selected by the RandomForest-based feature selection algorithm Boruta; the difference of the medians between the groups and a 95% confidence interval was built using the bootstrap approach. The Asymptotic Wilcoxon-Mann-Whitney Test was performed for miRNA combinations to compare different groups of donors. Benjamini-Hochberg correction was used to adjust the statistical significance for multiple comparisons. The most diagnostically significant miRNAs pairs were miR-107-miR-26b.5p and miR-375.3p-miR-26b.5p in the urine supernatant fraction that discriminated the group of healthy patients and PCa patients, as well as miR-31.5p-miR-16.5p, miR-31.5p-miR-200b, miR-31.5p-miR-30e.3p and miR-31.5p-miR-660.5p in the fraction extracellular vesicles that were different between healthy men and benign prostate hyperplasia patients. Such statistical criteria as the occurrence of individual significant miRNA pairs in the total number of comparisons, median ΔCt difference, and confidence interval can be useful tools for determining reliable markers of PCa.
How Glucocorticoids Affect the Neutrophil Life
Authors: Ronchetti Simona , Ricci Erika , Migliorati Graziella , Gentili Marco , Riccardi Carlo
Published: December 2018

Glucocorticoids are hormones that regulate several functions in living organisms and synthetic glucocorticoids are the most powerful anti-inflammatory pharmacological tool that is currently available. Although glucocorticoids have an immunosuppressive effect on immune cells, they exert multiple and sometimes contradictory effects on neutrophils. From being extremely sensitive to the anti-inflammatory effects of glucocorticoids to resisting glucocorticoid-induced apoptosis, neutrophils are proving to be more complex than they were earlier thought to be. The aim of this review is to explain these complex pathways by which neutrophils respond to endogenous or to exogenous glucocorticoids, both under physiological and pathological conditions.
Brassinosteroid Signaling in Plant–Microbe Interactions
Authors: Yu Mei-Hui , Zhao Zhe-Ze , He Jun-Xian
Published: December 2018

As sessile organisms, plants are frequently exposed to different stress conditions caused by either biotic or abiotic factors. Understanding the mechanisms that underlie plant interaction with the biotic and abiotic environments is fundamental to both plant biotechnology and sustainable agriculture. Brassinosteroids (BRs) are a group of plant-specific steroidal compounds essential for normal growth and development. Recent research evidence indicates that BRs are also actively involved in plant–environment interactions and play important roles in shaping plant fitness and the growth–defense trade-offs. In this minireview, we focus our attention on recent advances in the understanding of BR functions in modulating plant interactions with different pathogenic microbes, with particular focus on how BR signaling primes the plant innate immunity pathways and achieves a trade-off between growth and immunity.
Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics
Authors: Holstein Elisa , Binder Mathias , Mikulits Wolfgang
Published: December 2018

Signaling of the receptor tyrosine kinase Axl and its ligand Gas6 is crucially involved in the development of liver fibrosis and hepatocellular carcinoma (HCC) by activation of hepatic stellate cells and modulation of hepatocyte differentiation. Shedding of Axl’s ectodomain leads to the release of soluble Axl (sAxl), which is increased in advanced fibrosis and in early-to-late stage HCC in the presence and absence of cirrhosis. Here, we focus on the dynamics of Axl receptor shedding and delineate possible scenarios how Axl signaling might act as driver of fibrosis progression and HCC development. Based on experimental and clinical data, we discuss the consequences of modifying Axl signaling by sAxl cleavage, as well as cellular strategies to escape from antagonizing effects of Axl shedding by the involvement of the hepatic microenvironment. We emphasize a correlation between free Gas6 and free sAxl levels favoring abundant Gas6/Axl signaling in advanced fibrosis and HCC. The raised scenario provides a solid basis for theranostics allowing the use of sAxl as an accurate diagnostic biomarker of liver cirrhosis and HCC, as well as Axl receptor signaling for therapeutic intervention in stratified HCC patients.
Smart Antenna for Application in UAVs
Authors: Carneiro António Fernando Alves , Torres João Paulo N. , Baptista António , Martins Maria João M.
Published: December 2018

In the present paper, a smart planar electrically steerable passive array radiator (ESPAR) antenna was developed and tested at the frequency of 1.33 GHz with the main goal to control the main radiation lobe direction, ensuring precise communication between the antenna that is implemented in an unmanned aerial vehicle (UAV) and the base station. A control system was also developed and integrated into the communication system: an antenna coupled to the control system. The control system consists of an Arduino, a digital potentiometer, and an improved algorithm that allows defining the radiation-lobe direction as a function of the UAV flight needs. The ESPAR antenna was tested in an anechoic chamber with the control system coupled to it so that all previously established requirements were validated.
Mayall: A Framework for Desktop JavaScript Auditing and Post-Exploitation Analysis
Authors: Rapley Adam , Bellekens Xavier , Shepherd Lynsay A. , McLean Colin
Published: December 2018

Writing desktop applications in JavaScript offers developers the opportunity to create cross-platform applications with cutting-edge capabilities. However, in doing so, they are potentially submitting their code to a number of unsanctioned modifications from malicious actors. Electron is one such JavaScript application framework which facilitates this multi-platform out-the-box paradigm and is based upon the Node.js JavaScript runtime—an increasingly popular server-side technology. By bringing this technology to the client-side environment, previously unrealized risks are exposed to users due to the powerful system programming interface that Node.js exposes. In a concerted effort to highlight previously unexposed risks in these rapidly expanding frameworks, this paper presents the Mayall Framework, an extensible toolkit aimed at JavaScript security auditing and post-exploitation analysis. This paper also exposes fifteen highly popular Electron applications and demonstrates that two-thirds of applications were found to be using known vulnerable elements with high CVSS (Common Vulnerability Scoring System) scores. Moreover, this paper discloses a wide-reaching and overlooked vulnerability within the Electron Framework which is a direct byproduct of shipping the runtime unaltered with each application, allowing malicious actors to modify source code and inject covert malware inside verified and signed applications without restriction. Finally, a number of injection vectors are explored and appropriate remediations are proposed.
18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Assessing Treatment Response of Pulmonary Multidrug-Resistant Tuberculosis
Authors: Choi Joon Young , Jhun Byung Woo , Hyun Seung Hyup , Chung Myung Jin , Koh Won-Jung
Published: December 2018

Background: The purpose of this prospective study was to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for assessing treatment response in patients with pulmonary multidrug-resistant tuberculosis (MDR-TB). Methods: The study subjects were four patients diagnosed with pulmonary MDR-TB who underwent MDR-TB treatment and serial 18F-FDG PET/CT at baseline and 6 and 12 months after treatment. The highest lung maximum standardized uptake value (SUVmax), average SUVmean (average of all hypermetabolic parenchymal lesions), total metabolic lung volume (TMLV, sum of metabolic volumes from the hypermetabolic parenchymal lesions), and total lung glycolysis (TLG, sum of lesion glycolysis from the hypermetabolic parenchymal lesions) were determined as representative quantitative PET parameters for each patient. Results: All patients except one had negative sputum culture conversion after one month of treatment and achieved successful treatment outcomes. Baseline TMLV and TLG PET parameters were much higher in the single patient with treatment failure than in the remaining three patients with treatment success. No other PET parameters at baseline or follow-up were associated with the treatment results. Conclusions: Pretreatment volume-based 18F-FDG PET/CT lung parameters were associated with the final therapeutic response in patients with pulmonary MDR-TB. Our preliminary results warrant a larger study.
Bank Credit and Housing Prices in China: Evidence from a TVP-VAR Model with Stochastic Volatility
Authors: He Xie , Cai Xiao-Jing , Hamori Shigeyuki
Published: December 2018

Housing prices in China have been rising rapidly in recent years, which is a cause for concern for China’s housing market. Does bank credit influence housing prices? If so, how? Will the housing prices affect the bank credit system if the market collapses? We aim to study the dynamic relationship between housing prices and bank credit in China from the second quarter of 2005 to the fourth quarter of 2017 by using a time-varying parameter vector autoregression (VAR) model with stochastic volatility. Furthermore, we study the relationships between housing prices and housing loans on the demand side and real estate development loans on the supply side, separately. Finally, we obtain several findings. First, the relationship between housing prices and bank credit shows significant time-varying features; second, the mutual effects of housing prices and bank credit vary between the demand side and supply side; third, influences of housing prices on all kinds of bank credit are stronger than influences in the opposite direction.
Landscapes in the Eastern Mediterranean between the Future and the Past
Authors: Vogiatzakis Ioannis N. , Terkenli Theano S. , Trovato Maria Gabriella , Abu-Jaber Nizar
Published: December 2018

Landscapes have long been viewed as complex, synthetic entities reflecting the human imprint upon the land. [...]
5-(4-Bromophenyl)-7-(2,4-dimethoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine
Authors: Haq Kautsar , Liawati Mareta , Abdulloh Abdulloh , Suwito Hery
Published: December 2018

A derivative of dihydrotetrazolopyrimidine has been successfully synthesized through a cyclocondensation reaction between a chalcone derivative with 5-aminotetrazole. The molecular structure of the title compound was established based on Fourier transform infrared spectra (FTIR), high-resolution mass spectrometry (HRMS), 1D and 2D nuclear magnetic resonance (NMR) spectrum.
A Mini Review: Recent Advances in Surface Modification of Porous Silicon
Authors: Lee Seo Hyeon , Kang Jae Seung , Kim Dokyoung
Published: December 2018

Porous silicon has been utilized within a wide spectrum of industries, as well as being used in basic research for engineering and biomedical fields. Recently, surface modification methods have been constantly coming under the spotlight, mostly in regard to maximizing its purpose of use. Within this review, we will introduce porous silicon, the experimentation preparatory methods, the properties of the surface of porous silicon, and both more conventional as well as newly developed surface modification methods that have assisted in attempting to overcome the many drawbacks we see in the existing methods. The main aim of this review is to highlight and give useful insight into improving the properties of porous silicon, and create a focused description of the surface modification methods.
Physics of Discrete Impurities under the Framework of Device Simulations for Nanostructure Devices
Authors: Sano Nobuyuki , Yoshida Katsuhisa , Yao Chih-Wei , Watanabe Hiroshi
Published: December 2018

Localized impurities doped in the semiconductor substrate of nanostructure devices play an essential role in understanding and resolving transport and variability issues in device characteristics. Modeling discrete impurities under the framework of device simulations is, therefore, an urgent need for reliable prediction of device performance via device simulations. In the present paper, we discuss the details of the physics associated with localized impurities in nanostructure devices, which are inherent, yet nontrivial, to any device simulation schemes: The physical interpretation and the role of electrostatic Coulomb potential in device simulations are clarified. We then show that a naive introduction of localized impurities into the Poisson equation leads to a logical inconsistency within the framework of the drift-diffusion simulations. We describe a systematic methodology for how to treat the Coulomb potential consistently with both the Poisson and current-continuity (transport) equations. The methodology is extended to the case of nanostructure devices so that the effects of the interface between different materials are taken into account.
Ultrasonic Vibration Facilitates the Micro-Formability of a Zr-Based Metallic Glass
Authors: Han Guangchao , Peng Zhuo , Xu Linhong , Li Ning
Published: December 2018

Thermoplastic microforming not only breaks through the bottleneck in the manufacture of metallic glasses, but also offers alluring prospects in microengineering applications. The microformability of metallic glasses decreases with a reduction in the mold size owing to the interfacial size effect, which seriously hinders their large-scale applications. Here, ultrasonic vibration was introduced as an effective method to improve the microformability of metallic glasses, owing to its capabilities of improving the material flow and reducing the interfacial friction. The results reveal that the microformability of supercooled Zr35Ti30Cu8.25Be26.75 metallic glasses is conspicuously enhanced by comparison with those under quasi-static loading. The more intriguing finding is that the microformability of the Zr-based metallic glasses can be further improved by tuning the amplitude of the ultrasonic vibration. The physical origin of the above scenario is understood, in depth, on the basis of ultrasonic vibration-assisted material flow, as demonstrated by the finite element method.
Light Management Enhancement for Four-Terminal Perovskite-Silicon Tandem Solar Cells: The Impact of the Optical Properties and Thickness of the Spacer Layer between Sub-Cells
Authors: Hajjiah Ali , Parmouneh Fahad , Hadipour Afshin , Jaysankar Manoj , Aernouts Tom
Published: December 2018

Mechanical stacking of a thin film perovskite-based solar cell on top of crystalline Si (cSi) solar cell has recently attracted a lot of attention as it is considered a viable route to overcome the limitations of cSi single junction power conversion efficiency. Effective light management is however crucial to minimize reflection or parasitic absorption losses in either the top cell or in the light in-coupling of the transmitted light to the bottom sub-cell. The study here is focused on calculating an optimum performance of a four-terminal mechanically stacked tandem structure by varying the optical property and thickness of the spacer between top and bottom sub-cells. The impact of the nature of the spacer material, with its refractive index and absorption coefficient, as well as the thickness of that layer is used as variables in the optical simulation. The optical simulation is done by using the transfer matrix-method (TMM) on a stack of a semi-transparent perovskite solar cell (top cell) mounted on top of a cSi interdigitated back contact (IBC) solar cell (bottom cell). Two types of perovskite absorber material are considered, with very similar optical properties. The total internal and external short circuit current (Jsc) losses for the semitransparent perovskite top cell as a function of the different optical spacers (material and thickness) are calculated. While selecting the optical spacer materials, Jsc for both silicon (bottom cell) and perovskite (top cell) were considered with the aim to optimize the stack for maximum overall short circuit current. From these simulations, it was found that this optimum in our four-terminal tandem occurred at a thickness of the optical spacer of 160 nm for a material with refractive index n = 1.25. At this optimum, with a combination of selected semi-transparent perovskite top cell, the simulated maximum overall short circuit current (Jsc-combined, max) equals to 34.31 mA/cm2. As a result, the four-terminal perovskite/cSi multi-junction solar cell exhibits a power conversion efficiency (PCE) of 25.26%, as the sum of the perovskite top cell PCE = 16.50% and the bottom IBC cSi cell PCE = 8.75%. This accounts for an improvement of more than 2% absolute when compared to the stand-alone IBC cSi solar cell with 23.2% efficiency.
Specific Cutting Forces of Isotropic and Orthotropic Engineered Wood Products by Round Shape Machining
Authors: Goli Giacomo , Curti Rémi , Marcon Bertrand , Scippa Antonio , Campatelli Gianni , Furferi Rocco , Denaud Louis
Published: December 2018

The set-up of machining parameters for non-ferric materials such as wood and wood-based materials is not yet defined on a scientific basis. In this paper, a new rapid experimental method to assess the specific cutting coefficients when routing isotropic and orthotropic wood-based materials is presented. The method consists of routing, with different depths of cut, a given material previously machined to a round shape after having it fixed on a dynamometric platform able to measure the cutting forces. The execution of subsequent cuts using different depths of cut allows the calculation of the specific cutting coefficients. With the measurement being done during real routing operations, a method to remove machine vibrations was also developed. The specific cutting coefficients were computed for the whole set of grain orientations for orthotropic materials and as an average for isotropic ones. The aim of this paper is to present and validate the whole method by machining selected materials such as Polytetrafluoroethylene—PTFE (isotropic), Medium Density Fiberboard—MDF (isotropic), beech Laminate Veneer Lumber—LVL (orthotropic) and poplar LVL (orthotropic). The method and the proposed analysis have been shown to work very effectively and could be used for optimization and comparison between materials and processes.
Rheological Behavior and Microstructure Characteristics of SCC Incorporating Metakaolin and Silica Fume
Authors: Ling Gang , Shui Zhonghe , Sun Tao , Gao Xu , Wang Yunyao , Sun Yu , Wang Guiming , Li Zhiwei
Published: December 2018

This study explores the effects of metakaolin (MK) and silica fume (SF) on rheological behaviors and microstructure of self-compacting concrete (SCC). The rheology, slump flow, V-funnel, segregation degree (SA), and compressive strength of SCC are investigated. Microstructure characteristics, including hydration product and pore structure, are also studied. The results show that adding MK and SF instead of 4%, 6% and 8% fly ash (FA) reduces flowability of SCC; this is due to the fact that the specific surface area of MK and SF is larger than FA, and the total water demand increases as a result. However, the flowability increases when replacement ratio is 2%, as the small MK and SF particles will fill in the interstitial space of mixture and more free water is released. The fluidity, slump flow, and SA decrease linearly with the increase of yield stress. The total amount of SF and MK should be no more than 6% to meet the requirement of self-compacting. Adding MK or SF to SCC results in more hydration products, less Ca(OH)2 and refinement of pore structure, leading to obvious strength and durability improvements. When the total dosage of MK and SF admixture is 6%, these beneficial effects on workability, mechanical performance, and microstructure are more significant when SF and MK are applied together.
Natural Dyes and Their Derivatives Integrated into Organic Solar Cells
Authors: Vohra Varun
Published: December 2018

Natural photosynthetic systems contain several dyes such as carotenoids or chlorophylls which are adequately arranged to produce efficient photoinduced charge separation and electron transfer. Several research groups have attempted integrating these natural dyes and photosynthetic systems into functional organic solar cells (OSCs) producing power conversion efficiencies (PCEs) up to 0.99%. The studies presented in this short review emphasize that functionalization of natural dyes can considerably improve their PCEs. For instance, chlorophyll derivatives can yield PCEs up to 2.1%, and copolymers produced with isoindigo as an electron-deficient unit generate high PCEs up to 8%, respectively, when combined with fullerene C70 based electron acceptors in the OSC active layers. An alternative approach for natural dye integration into OSC architectures is to place these light-harvesting antennas at the interface between the active layer and the charge collection layers in these low-cost photovoltaic devices. This strategy produces large PCE increases up to 35% with respect to OSCs prepared without the interlayer. When light-harvesting systems are combined with silver nanoprisms as interlayers, additional localized surface plasmon resonance effects result in high-performance OSCs that integrate natural photosynthetic systems and demonstrate a PCE over the milestone value of 10%.
Rapid Processing of Wafer-Scale Anti-Reflecting 3D Hierarchical Structures on Silicon and Its Templation
Authors: Bindra Harsimran Singh , R. Jaikrishna , Kumeria Tushar , Nayak Ranu
Published: December 2018

Hierarchically structured silicon (Si) surfaces with a combination of micro/nano-structures are highly explored for their unique surface and optical properties. In this context, we propose a rapid and facile electroless method to realize hierarchical structures on an entire Si wafer of 3″ diameter. The overall process takes only 65 s to complete, unlike any conventional wet chemical approach that often combines a wet anisotropic etching of (100) Si followed by a metal nanoparticle catalyst etching. Hierarchical surface texturing on Si demonstrates a broadband highly reduced reflectance with average R% ~ 2.7% within 300–1400 nm wavelength. The as-fabricated hierarchical structured Si was also templated on a thin transparent layer of Polydimethylsiloxane (PDMS) that further demonstrated prospects for improved solar encapsulation with high optical clarity and low reflectance (90% and 2.8%).
Some Symmetric Identities Involving the Stirling Polynomials Under the Finite Symmetric Group
Authors: Lim Dongkyu , Qi Feng
Published: December 2018

In the paper, the authors present some symmetric identities involving the Stirling polynomials and higher order Bernoulli polynomials under all permutations in the finite symmetric group of degree n. These identities extend and generalize some known results.
Some Identities Involving Fibonacci Polynomials and Fibonacci Numbers
Authors: Ma Yuankui , Zhang Wenpeng
Published: December 2018

The aim of this paper is to research the structural properties of the Fibonacci polynomials and Fibonacci numbers and obtain some identities. To achieve this purpose, we first introduce a new second-order nonlinear recursive sequence. Then, we obtain our main results by using this new sequence, the properties of the power series, and the combinatorial methods.
Transcriptome Analysis of Phycocyanin-Mediated Inhibitory Functions on Non-Small Cell Lung Cancer A549 Cell Growth
Authors: Hao Shuai , Li Shuang , Wang Jing , Zhao Lei , Yan Yan , Cao Qi , Wu Tingting , Liu Liyun , Wang Chengtao
Published: December 2018

Phycocyanin (PC), derived from cyanobacteria and Spirulina cells, is a type of natural antineoplastic marine protein. It has been reported that phycocyanin exerts an antitumor function in non-small cell lung cancer (NSCLC) cells, but the underlying mechanism has not been elucidated. In this research, a transcriptome study was performed to investigate the regulatory mechanisms of phycocyanin on human NSCLC A549 cells. The survival rate and proliferation ability of A549 cells were markedly reduced by phycocyanin, along with abnormal morphologic changes. The transcriptome analysis showed that 2970 genes were differentially expressed after phycocyanin treatment in A549 cells, including 1431 down-regulated and 1539 up-regulated genes. Gene ontology and KEGG analysis suggested that some classical pathways, such as Wnt, NF-κB, and PI3K-AKT signaling, were significantly enriched. Strikingly, protein–protein interaction (PPI) analysis showed that ubiquitin-C (UBC) occupied the highest degree (the highest number of interactions) in differential genes, indicating that it might play a key role in the phycocyanin-mediated regulatory process in A549 cells. Moreover, qRT-PCR results showed consistent expression trends of differential genes with transcriptome analysis. Consequently, this study has provided a theoretical basis for regulation of phycocyanin in A549 cells, which lays a foundation for the treatment of NSCLC.
Reduced Number of Adipose Lineage and Endothelial Cells in Epididymal fat in Response to Omega-3 PUFA in Mice Fed High-Fat Diet
Authors: Adamcova Katerina , Horakova Olga , Bardova Kristina , Janovska Petra , Brezinova Marie , Kuda Ondrej , Rossmeisl Martin , Kopecky Jan
Published: December 2018

We found previously that white adipose tissue (WAT) hyperplasia in obese mice was limited by dietary omega-3 polyunsaturated fatty acids (omega-3 PUFA). Here we aimed to characterize the underlying mechanism. C57BL/6N mice were fed a high-fat diet supplemented or not with omega-3 PUFA for one week or eight weeks; mice fed a standard chow diet were also used. In epididymal WAT (eWAT), DNA content was quantified, immunohistochemical analysis was used to reveal the size of adipocytes and macrophage content, and lipidomic analysis and a gene expression screen were performed to assess inflammatory status. The stromal-vascular fraction of eWAT, which contained most of the eWAT cells, except for adipocytes, was characterized using flow cytometry. Omega-3 PUFA supplementation limited the high-fat diet-induced increase in eWAT weight, cell number (DNA content), inflammation, and adipocyte growth. eWAT hyperplasia was compromised due to the limited increase in the number of preadipocytes and a decrease in the number of endothelial cells. The number of leukocytes and macrophages was unaffected, but a shift in macrophage polarization towards a less inflammatory phenotype was observed. Our results document that the counteraction of eWAT hyperplasia by omega-3 PUFA in dietary-obese mice reflects an effect on the number of adipose lineage and endothelial cells.