bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitigar las Consecuencias del Fenómeno de El Niño en las Finanzas de una Compañía
Authors: Merino Dominguez Rigoberto
Published: July 2018

En el presente documento se describe como las compañías pueden mitigar los impactos causados por el fenómeno del niño en sus finanzas. Debido a los avances tecnológicos de predicción meteorológica, hoy en día se puede predecir con alto grado de certidumbre la llegada e intensidad del fenómeno de El Niño. Esta información luego puede ser utilizada por los encargados del manejo del riesgo en las compañías para diseñar planes de mitigación con el objetivo de reducir sus impactos.
Complejidad en redes neuronales - retropropagación
Authors: Vargas Sánchez German Gonzalo
Published: July 2018

Este artículo muestra una forma para aplicar el concepto de complejidad a redes neuronales artificiales, particularmente a las que utilizan el método backpropagation. Apoyados en el principio hologramático del pensamiento complejo se encontró un método para preparar los datos de entrada a la red neuronal de acuerdo con los valores esperados de las salidas, separando los datos en dos conjunto los cuales tienen como patrones de entrenamiento el promedio de cada conjunto de datos.
Respuesta a la infiltración en distintos complejos suelo-vegetación en las sierras de Ventania, Argentina
Authors: Delgado Maria Isabel , Julia Gaspari Fernanda , Elba Senisterra Gabriela
Published: July 2018

La infiltración de un suelo es un importante indicador respecto de la eficiencia de los procesos de irrigación y drenaje, permitiendo optimizar el rendimiento de los cultivos. El objetivo de este trabajo fue establecer la infiltración del suelo bajo distintos usos del mismo. El estudio se centró en la cuenca del arroyo Belisario, en el Sudoeste de la provincia de Buenos Aires; la infiltración se midió utilizando un infiltrómetro de anillo simple. Junto a la escasa cobertura del suelo, tuvo un papel fundamental la compactación que presenta el suelo. Durante el ensayo el agua tardó más en infiltrarse en los sectores con Pastizal Degradado, favoreciéndose el escurrimiento superficial y potenciando sus posibles efectos adversos. El Pastizal natural en buenas condiciones presentó un efecto superador en cuanto a su capacidad de infiltración, secundada por la Cobertura forestal y luego por el Cultivo conservacionista.
O fetiche das mercadorias: a face oculta do contato entre índios e brancos
Authors: Leopoldi José Sávio
Published: July 2018

O trabalho visa discutir a relação dos grupos indígenas com os produtos industrializados, disponibilizados pelos brancos no processo de contato interétnico. Aquela relação sempre foi uma ponte permanentemente reconstruída entre as populações silvícolas e quaisquer segmentos da sociedade não-índia com que entravam em contato. A despeito de inevitáveis resistências culturais, incertezas, contradições e desafios que a aceitação das mercadorias implicava, o caminho foi um só: a submissão indígena ao poder dos itens industrializados que se foram impondo à vida cotidiana tanto em termos tecnológicos quanto, e especialmente, simbólicos. Mais do que à força das armas, os índios se curvaram ao “exército das mercadorias”, submetendo-se ao poder dos brancos, materializado no dinheiro e nos itens de consumo.
The Effect of Financial Performance toward Profit-Sharing Rate on Mudharabah Deposit of Sharia Banking in Indonesia
Authors: Sudarsono Heri , Saputri Miranti Aprilia
Published: July 2018

Abstract This study aims to determine the effect of financial performance in the form of Return On Assets (ROA), Operational Expense to Operating Income (OER), Finance to Deposits Ratio (FDR), Non Performing Finance (NPF), and Interest Rate to profit-sharing rate on mudharabah deposit of Sharia banking in Indonesia period 2011.1 to 2017.10. Data analysis method used is Auto-Regressive Distributed Lag (ARDL) which can analyze the relation between independent variable to dependent variable in long term and short term. The results of data analysis show that in the short term ROA and OER variable negatively affect the profit-sharing rate mudharabah deposits. While the variable of FDR and Interest rate have positive effect to profit-sharing rate of mudharabah deposit, on the other hand NPF variable does not affect to profit-sharing level of mudharabah deposit. Meanwhile in the long run the variable of FDR and OER have negative effect, the variable of Interest rate has positive effect. Meanwhile, the ROA and NPF variables do not affect the profit-sharing of mudharabah depositsAbstrak Penelitian ini bertujuan untuk mengetahui pengaruh kinerja keuangan berupa Return On Asset (ROA), Biaya Operasional terhadap Pendapatan Operasional (BOPO), Finance to Deposits Ratio (FDR), Non Performing Finance (NPF), dan Suku Bunga terhadap tingkat bagi hasil deposito mudharabah pada perbankan syariah di Indonesia periode tahun 2011.1 sampai 2017.10. Metode analisis data yang digunakan adalah Auto-Regressive Distributed Lag (ARDL) yang dapat menganalisa keterkaitan antara variabel independen terhadap variabel dependen dalam jangka panjang dan jangka pendek. Hasil analisis data menunjukkan bahwa dalam jangka pendek variabel ROA dan BOPO berpengaruh negatif terhadap tingkat bagi hasil deposito mudharabah. Sedangkan variabel FDR dan Suku Bunga berpengaruh positif terhadap tingkat bagi hasil deposito mudharabah, dilain pihak variabel NPF tidak berpengaruh terhadap tingkat bagi hasil deposito mudharabah. Dan dalam jangka panjang variabel FDR dan BOPO berpengaruh negatif, variabel Suku Bunga berpengaruh positif. Sementara itu, variabel ROA dan NPF masing-masing tidak berpengaruh terhadap tingkat bagi hasil deposito mudharabah
Pengelolaan Jurnal Elektronik Bidang Perpustakaan Menuju Jurnal Terakreditasi
Authors: Junandi Sri
Published: July 2018

The management of scientific journals in order to achieve national accredited scientificjournals requires an effective and efficient Journal Management and ManagementSystem. Management and Management Systems This journal should refer tothe instruments and criteria required by the accreditation of national journals andinternational indexing agencies. Periodical Manager of Library and Information Sciencehas implemented most of the instruments and criteria set out in accordance withthe Director General of Hig. Periodical Manager of Library and Information Sciencehas implemented most of the instruments and criteria set out in accordance with theDirector General of Higher Education Directive No. 1 2014 on Guidelines for Accreditationof Scientific Periodic Issue. In addition BIP managers are actively following thedevelopment related to the management of journals by attending workshops, training,mentoring, electronic journals governance grants, accreditation of scientific journals,journal indexation. Armed with genuine efforts and willingness Periodic Library andInformation Sciences managed to qualify to achieve accreditation status as the firstaccredited library of science journals in Indonesia with Decree No. 51 / E / KPT / 2017valid for five years ahead of the period 2017-2022. Armed with genuine efforts andwillingness Periodic Library and Information Sciences managed to qualify to achieveaccreditation status as the first accredited library of science journals in Indonesia withDecree No. 51 / E / KPT / 2017 valid for five years ahead of the period 2017-2022.
A IMPORTÂNCIA SOCIAL DO IPTU E OS PROBLEMAS EM SUA GESTÃO
Authors: Leão Celina Gontijo , Frias Lincoln
Published: July 2018

Os impostos não servem apenas para arrecadar recursos, eles também podem ser usados para buscar objetivos socialmente desejáveis. O objetivo deste artigo é mostrar que o Imposto sobre a Propriedade Predial e Territorial Urbana (IPTU) não tem sido utilizado em toda a sua potencialidade. Por meio da análise de dados empíricos, da legislação e de revisão não sistemática da literatura, o trabalho mostra como as alíquotas progressivas de acordo com características do imóvel e progressivas no tempo têm sido pouco utilizadas, fazendo com o que o IPTU seja regressivo em muitas situações, isto é, exija um esforço maior de quem tem uma capacidade contributiva menor. Além disso, o artigo elenca diversos problemas na gestão deste tributo, em especial, a ausência de cobrança efetiva (por causa de seus possíveis efeitos eleitorais) e as dificuldades de se atualizar a Planta Genérica de Valores (PGV, utilizada na estimação do valor dos imóveis). Essa é uma situação inadequada porque, com alíquotas progressivas e PGV atualizada, o IPTU permitiria uma repartição mais justa da carga tributária, estimularia a ocupação ordenada do território e ajudaria a garantir a autonomia financeira do município.
ASPECTOS SOCIOECONÔMICOS E AMBIENTAIS DOS EMPREENDIMENTOS DE BORRACHARIAS DO MUNICÍPIO DE PAU DOS FERROS-RN
Authors: Medeiros Lira Felipe , De Oliveira Pinto Filho Jorge Luís , Timoteo Júnior José Flávio , Cruz de Sousa Cláwsio Rogério , Monteiro de Barros Adriano David
Published: July 2018

Este trabalho objetiva realizar um diagnóstico socioeconômico das borracharias do município de Pau dos Ferros/RN, através da descrição das atividades, processos e serviços desses empreendimentos. Os procedimentos metodológicos dessa pesquisa foram: pesquisa bibliográfica e obtenção dos dados em campo. Constatou-se que atualmente no Pau dos Ferros – RN existem 23 borracharias em funcionamento, sendo classificadas conforme o SEBRAE (2016) quanto ao porte em: micro com até 9 empregados (91%) e pequeno variando de 10 a 49 empregados (9%). Verificou-se também que os principais impactos ambientais destes empreendimentos relacionam-se com o destino incorreto de insumos, pneus inservíveis e resíduos sólidos. Evidenciou-se que a proposição de diretrizes de gestão ambiental tem melhorias sobre os aspectos socioeconômicos, uso dos recursos naturais e insumos (inputs), aspectos ambientais (outputs) e, análise ambiental desse setor. Para tanto, é necessário investir em ações que contribuam para o aperfeiçoamento dessa atividade econômica, para assegurar a legalidade ambiental desse arranjo comercial.
UM ESTUDO LONGITUDINAL SOBRE A RELAÇÃO ENTRE PLANEJAMENTO ESTRATÉGICO E DESEMPENHO NAS UNIVERSIDADES FEDERAIS DO NORDESTE BRASILEIRO
Authors: Santos Alexandre Rodrigues , Martins Daniel Felipe Victor , Barbosa Flávia Lorenne Sampaio , Moura Héber José de , Moura Elizabeth Alencar de
Published: July 2018

A pesquisa tem por objetivo analisar a relação entre o Planejamento Estratégico (PE) e o Desempenho (D) alcançado pelas Instituições Federais de Ensino Superior (IFES) do Nordeste. Quanto aos procedimentos metodológicos, a pesquisa utiliza uma abordagem de natureza quantitativa porque trata os seus dados a partir da aplicação de técnicas de estatística descritiva. Nesse sentido, foram analisados os principais indicadores de gestão compreendidos longitudinalmente entre os anos de 2005 a 2014 das IFES do Nordeste. A análise dos resultados apontou que a relação entre o planejamento estratégico e o desempenho acontece na medida em que há uma mensuração e uma evolução positiva das variáveis relacionadas.
CHEMOMETRIC-BASED ELECTRONIC NOSE APPLICATION TO PORK OIL AND OLIVE OIL USING THE ODOR PATTERN CLASSIFICATIONS
Authors: Tazi Imam , Muthmainnah Muthmainnah , Suyono Suyono , Ainur Avin
Published: July 2018

A chemometric-based electronic nose has designed for analyzing pork oil and olive oil  using the odor pattern classifications. The electronic nose (e-nose) built from a combination of several chemical sensors derived from a semiconductor. The data retrieval was done by vaporizing the sample, then being captured by the sensor and identified by the electronic nose (e-nose). The output data from the electronic nose is the voltage released by each sensor. The analyzed samples were 100% olive oil, 100% pork oil and a combination of olive oil and pork oil with a ratio of 50%: 50%. The result of pattern classification using linear discriminant analysis (LDA) method shows that each sample is clustered well with the percentage of first discriminant function value is 87,9% and second discriminant function is 12,1%.
Análise da Revisão Cochrane: Alta Hospitalar Precoce para Hospitalização Domiciliária. Cochrane Database Syst Rev. 2017;6:CD000356.
Authors: Alves Mariana , Vieira Miguel Bigotte , Costa João , Carneiro António Vaz
Published: July 2018

A hospitalização domiciliária é um serviço que proporciona tratamento a doentes com doença aguda no próprio domicílio, os quais noutras condições necessitariam de internamento hospitalar em enfermaria de agudos. No entanto, o benefício clínico desta intervenção e o seu efeito nos custos em saúde não se encontram estabelecidos. Esta revisão sistemática Cochrane teve como objectivo avaliar a eficácia e custos associados aos cuidados de doentes admitidos no serviço de hospitalização domiciliária em comparação com internamento hospitalar habitual. Foi realizada revisão sistemática da literatura através de pesquisa nas seguintes bases de dados - The Cochrane Effective Practice and Organisation of Care Group (EPOC) register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, e EconLit - até 9 de janeiro de 2017. Foram incluídos 32 ensaios clínicos aleatorizados (2 dos quais não publicados), incluindo 4746 doentes. A presente revisão detetou evidência insuficiente do benefício económico (através de uma redução no período de internamento hospitalar) ou melhoria dos resultados clínicos da hospitalização domiciliária.
Effects of Red Fruit (Pandanus conoideus Lam) Oil on Malondialdehyde Level and Spermatozoa Quality in Mice (Mus musculus) Exposed to Monosodium Glutamate
Authors: Agustina Widayati , Widjiati Widjiati , Hayati Alfiah
Published: July 2018

This study aimed to determine the effects of red fruit (Pandanus conoideus Lam) oil on MDA levels and spermatozoa quality in mice (Mus musculus) exposed to MSG. The quality includes motility, viability, concentration, and morphology of spermatozoa. This experimental study used randomized post-test only control group design. The subjects of this study were 25 mice (Mus musculus), divided into 5 groups (5 mice per group). K- group received distilled water for 35 days. K+ group received 4 mg/g BW MSG for 21 days. P1, P2, and P3 treatment groups received 4 mg/g BW MSG for 21 days and 0.02; 0.04; 0.08 ml/g BW red fruit oil, respectively, from day 22 to 35. The results showed that mean spermatozoa morphology in K-, K+, P1, P2, P3 groups were as follows: 0.86; 0.56; 0.67; 0.61; and 0.87 (%). The spermatozoa concentrations were sequentially as follows: 21; 10; 15; 32,8,19 (107 cells/ml). The spermatozoa's vitalities were as follows: 0,64; 0,14; 0,24; P2: 0.36; 0.68 (%). MDA levels were respectively: 0.29; 0.60; 0.35; 0.23; and 0.19 (nm). As a conclusion, testicular MDA levels in mice exposed to MSG and given with red fruit oil were lower than those in mice exposed to MSG without receiving red fruit oil. The quality of spermatozoa in mice exposed to MSG and receiving red fruit oil was higher than that of mice exposed to MSG without being given with red fruit oil.
Purple Rosella (Hibiscus sabdariffa Linn.) Petal Extract Prevents Hepatocyte Degeneration in Wistar Rats Exposed to Cigarette Smoke
Authors: Ulilalbab Arya , Wiratmadi Bambang , Adriani Merryana
Published: July 2018

Currently, the number of smokers in Indonesia is still high. Cigarette smoke contains free radicals. This study aimed to analyze the effects of purple rosella petal extract on the prevention of hepatocyte degeneration in Wistar rats exposed to cigarette smoke. Twenty male rats were divided into four groups: negative control, positive control, treatment group receiving 270 mg/kg BW purple rosella petal extract, and treatment group receiving 540 mg/kg BW purple rosella calyx extract. Negative control was only given with standard feed. Positive control was given with standard feed and exposed to 2 cigarettes a day. Treatment groups were fed with standard feed and administered with rosella extract in the morning then exposed to 2 cigarettes every day. This study was conducted for 28 days. At the end of the study, hepatocyte degeneration was observed in liver histopathology stained with hematoxilin eosin. The administration of purple rosella petal extracts in the doses of 540 mg/kgBW and 270 mg/kgBW significantly (p<0.05) prevented hepatocyte degeneration. Purple rosella petal extract is able to prevent hepatocyte degeneration in Wistar rats exposed to cigarette smoke.
On the Numerical Modeling of FENE-CR Viscoelastic Droplet Impact Dynamics by the Volume Of Fluid Method
Authors: Tembely Moussa
Published: July 2018

In this paper, a numerical modeling of the impact, spreading, and eventually rebound of a viscoelastic droplet is reported. The numerical model is based on the volume of fluid (VOF) method coupled with the FENE-CR constitutive equations, and accounts for both the surface tension and the substrate wettability. The FENE-CR constitutive equations are used to model the polymer solution, while taking advantage of its rheological characterization. The comparison is performed between droplets of Newtonian solvent and a monodisperse polymer solution. The droplet impact on both hydrophilic and superhydrophobic substrate is analyzed through a detailed analysis of the spreading diameter evolution. It is found that while the droplet kinematic phase seems independent of the substrate and fluids properties, the recoiling phase is highly related to all of them. In addition, the model infers a critical polymer concentration above which the droplet rebound from a superhydrophobic substrate is suppressed. The simulation is of particular interest to ink-jet processing, and demonstrates the capability of the model to handle complex non-Newtonian droplet dynamics.
The Non-Uniform and Asymmetric Thermal Radiation upon the Human Physiological Responses in Outdoor Environment
Authors: Kurazumi Yoshihito , Fukagawa Kenta , Sakoi Tomonori , Aruninta Ariya , Yamashita Ken
Published: July 2018

Depending on human body conditions and environmental conditions, it is sometimes difficult to conduct subject experiments. In such cases, it is effective to use a thermal manikin. There are few studies that investigate the effect of the non-uniform and asymmetric outdoor thermal environment on the mean skin temperature. The purpose of this study is to clarify the influence of the non-uniform and asymmetric thermal radiation of short-wavelength solar radiation in an outdoor environment on the calculation of the mean skin temperature. The skin temperature of the front of the coronal surface, which was facing the sun and where the body received direct short-wavelength solar radiation, and the skin temperature of the rear of the coronal surface, which was in the shadow and did not receive direct short-wavelength solar radiation were respectively measured. The feet, upper arm, forearm, hand and lower leg, which are susceptible to short-wavelength solar radiation in a standing posture, had a noticeable difference in skin temperature between sites in the sun and in shade. The mean skin temperature of sites facing the sun was significantly higher than the mean skin temperature of those in the shade.
Filamentous Aggregates of Tau Proteins Fulfil Standard Amyloid Criteria
Authors: Dułak Dawid , Gadzała Małgorzata , Banach Mateusz , Ptak Magdalena , Wisniowski Zdzisław , Konieczny Leszek , Roterman Irena
Published: July 2018

Abnormal filamentous aggregates formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril’s long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure, which can be thought of as a distorted spherical micelle, which in limit form appears to be the ribbon-like micelle.
Modification of Nanofiber Support Layer for Thin Film Composite Forward Osmosis Membranes via Layer-By-Layer Polyelectrolyte Deposition
Authors: Gonzales Ralph Rolly , Park Myoung Jun , Tijing Leonard , Han Dong Suk , Phuntsho Sherub , Shon Hokyong
Published: July 2018

Electrospun nanofiber-supported thin film composite membranes are among the most promising membranes for seawater desalination via forward osmosis. In this study, a high-performance electrospun polyvinylidenefluoride (PVDF) nanofiber-supported TFC membrane was successfully fabricated after molecular layer-by-layer polyelectrolyte deposition. Negatively-charged electrospun polyacrylic acid (PAA) nanofibers were deposited on electrospun PVDF nanofibers to form a support layer consisted of PVDF and PAA nanofibers. This resulted to a more hydrophilic support compared to the plain PVDF nanofiber support. The PVDF-PAA nanofiber support then underwent a layer-by-layer deposition of polyethylenimine (PEI) and PAA to form a polyelectrolyte layer on the nanofiber surface prior to interfacial polymerization, which forms the selective polyamide layer of TFC membranes. The resultant PVDF-LbL TFC membrane exhibited enhanced hydrophilicity and porosity, without sacrificing mechanical strength. As a result, it showed high pure water permeability and low structural parameter values of 4.12 Lm−2h−1bar−1 and 221 µm, respectively, significantly better compared to commercial FO membrane. Layer-by-layer deposition of polyelectrolyte is therefore a useful and practical modification method for fabrication of high performance nanofiber-supported TFC membrane.
Environmental Issues Related to the Elderly and Physically Disabled People in Different Life Situations
Authors: Katunský Dušan , Brausch Carsten
Published: July 2018

In Europe we can see a change in the social structure in the last period. Average life expectancy has increased dramatically over the last 50 years. Because of the improved life situation and advanced level of health care, older people are slower. With advancing age, the likelihood of experiencing a variety of constraints such as visual impairment, reduced hearing or physical ability increases. In such a life stage tenants are often forced to leave their long-term living space because these homes can not serve "new" individual needs and the resulting personal protection goal. This transition from the privacy of their home to the new environment often appears to be a painful change. They will take their familiar and well-known surroundings, because their homes can not be adapted to serve new needs. It must be the policy’s role to create a new inclusive social space and the requirement for architects and designers to create new goals for the design of an adaptable environment. This is a comprehensive approach to the design of the outer and inner space that could serve people even if there is an unexpected situation and changes in movement and physiological limitations of older people. The contribution shows the results of the survey conducted in Germany and Slovakia. In the survey respondents expressed their opinion on what they considered important in creating an adaptive environment. Results are processed graphically with explanation. The results were mainly for designers and developers of the indoor environment. Based on the results of the questionnaire survey, studies of possible modifications in the interior of the flats were then prepared. The contribution yielded these results in three age groups of respondents; i. people aged 35, 50 and over 50.
Gallstone Magnesium Distributions from Optical Emission Spectroscopy
Authors: Pathak Ashok K. , Rai Nilesh K. , Kumar Rohit , Rai Pradeep K. , Rai Awadhesh K. , Parigger Christian G.
Published: July 2018

This work reports measurements of calcified gallstone elemental compositions using laser-induced optical emission spectroscopy. The experimental results support the importance of the magnesium concentration in gallstone growth. Granular stones reveal an increased magnesium concentration at the periphery of the granules, suggesting the inhibition of further growth. Non-granular gallstones reveal lower overall magnesium concentrations but with higher values near the center.
No Need for Dark-Matter, Dark-Energy or Inflation, Once Ordinary Matter is Properly Represented?
Authors: Knoll Yehonatan
Published: July 2018

In a recent Foundations of Physics paper [5] by the current author it was shown that, when the self-force problem of classical electrodynamics is properly solved, the representation of matter which results becomes a plausible ontology underlying QM's statistical description. In the current paper we extend this result, showing that ordinary matter, thus represented, possibly suffices in explaining the outstanding observations currently requiring for this task the contrived notions of dark-matter, dark-energy and inflation. The single `fix' to classical electrodynamics, demystifying both very small and very large scale physics, should be contrasted with other ad hoc solutions to either problems. Instrumental to our cosmological model is scale covariance (and `spontaneous breaking' thereof), a formal symmetry of CE which we consider to be just as important as its Poincare covariance.
Inhibition of Experimental Choroidal Neovascularization by a Novel Peptide Derived from Calreticulin Anti-Angiogenic Domain
Authors: Bee Youn-Shen , Chen Jinying , Tsai Pei-Jhen , Sheu Shwu-Jiuan , Lin Hsiu-Chen , Huang Hu , Liu Guei-Sheung , Tai Ming-Hong
Published: July 2018

Choroidal neovascularization (CNV) is a key pathological feature of several of the leading causes of vision loss including neovascular age-related macular degeneration. Here we show that a calreticulin anti-angiogenic domain (CAD)-like peptide 27, CAD27, inhibited in vitro angiogenic activities, including tube formation and migration of endothelial cells, and suppressed vascular sprouting from rat aortic ring explants. In rat model of laser-induced CNV, we demonstrate that intravitreal injection of CAD27 significantly attenuated the formation of CNV lesions as measured via fundus fluorescein angiography and choroid flat-mounts (19.5% and 22.4% reductions at 10μg and 20μg of CAD27 injected, respectively). Similarly, the reduction of CNV lesions was observed in the groups of rats that had received topical applications of CAD27 (choroid flat-mounts: 17.9% and 32.5% reductions at 10μg/mL and 20μg/mL of CAD27 installed, respectively). Retinal function was unaffected, as measured using electroretinography in both groups received interareal injection or topical applications of CAD27 at least for 9 days. These findings show that CAD27 can be used as a potential therapeutic alternative for targeting CNV in the diseases such as neovascular age-related macular degeneration.
An Autonomous Wireless Device for Real-Time Monitoring of Water Needs
Authors: BORRERO JUAN D , FERNANDEZ JOSE GUILLERMO , RODRIGUEZ CAMILO
Published: July 2018

A The agri-food sector is in full renovation, continuously demanding new systems that allow farmers to facilitate their work. Efficient agricultural practices are essential for increasing farm profitability. Efficient agricultural practices can be increased by understanding and managing water neeeds. However, real-time monitoring of water needs is currently slow, and irrigation decisions are based on previous data or physical evidence. Furthermore, the prices of automatic systems for collecting data from several sources (soil and climate) are expensive and the autonomy is very low. Emerging Internet of Things (IoT) technologies such as wireless sensor networks can be used to collect vast amounts of data recorded via apps. By means of an LPWAN communication the farmer can know in real time the state of his crops thanks to a large number of sensors connected wirelessly and distributed across his farm. This paper presents a low consumption solution based on LoRaWAN technology. The wireless sensor node, called BoX, exhibits very low power since it has been optimized both in terms of hardware and software. The result is a higher degree of autonomy than commercial motes. That will allow the farmer to have all the information necessary to achieve an efficient management of his crops with full autonomy.
KEEFEKTIFAN METODE BILINGUAL INTENSIF UNTUK KEMAMPUAN MEMBACA DAN MENULIS PADA PENDIDIKAN KEAKSARAAN MASYARAKAT SAMIN BLORA
Authors: Hapsari Melati Indri , Hadi Sanoto
Published: July 2018

This research aimed to know if in Samin community reading and writing skills of literacy education participants taught with intensive bilingual method are better than those taught with SAS method. The research conducted in Tanduran Village Blora Regency in 2010, involved 40 research subjects comprising 20 subjects for experimental group with intensive bilingual method and 20 subjects with SAS method for controlling group. The data obtained were analyzed in two stages i.e. in the preliminary analysis and in hypothesis testing. The result of the research indicates, the reading and writing skills of literacy education participants in Samin community taught with intensive bilingual method are better than those taught wit SAS method.
PENGEMBANGAN MODEL PENDIDIKAN LIFE SKILLS BERBASIS KEWIRAUSAHAAN MELALUI EXPERIENTIAL LEARNING
Authors: Prasetyo Iis , Tohani Entoh , Sumarno Sumarno
Published: July 2018

The existing life skill education program is not effective to reduce community poverty as the program just focus on producing more community hardskills than community softskills. This research aimed to create a model of entrepreneurship based 4-H lifeskills to decrease rural poverty. This research was conducted as from May through November 2013, in three regions of Gunung Kidul, Special Region of Yogyakarta. The data were collected by interview, documentation, observation and questionaire then analysed qualitatively and quantitatively. Research result shows: (1) most of the target research group members have dificulties in implementing several skills they obtained in the previous training; (2) the 4-H lifeskills model designed on the basis of empirical community condition is able to optimalize the use of the target group member resources; and (3) the model testing shows all of the three target groups have increasing mean of 4-H lifeskills perception. It means the model 4-H developed by researcher are effective.
GUSJIGANG; KARAKTER KEMANDIRIAN MASYARAKAT KUDUS MENGHADAPI INDUSTRIALISASI
Authors: Ihsan M.
Published: July 2018

Data antropologi, demografi dan perilaku ekonomi
masyarakat kudus menunjukkan bahwa masyarakat
Kudus adalah komunitas yang bercirikan sosial santri-
muslim yang bertumpu pada bidang usaha industri
pengolahan (62,72 %) dan perdagangan (24,12 %).
Perilaku tersebut dibangun di atas fondasi tradisi
lokal Gusjigang. Hubungan antara basis tradisi
(local value) dan potensi masyarakatnya (local asset)
dengan pelaksanaan industrialisasi seringkali dengan
differensiasi structural yang patut dicermati secara
serius, terutama ketika hal tersebut berada dalam
cengkeraman globalisasi. Intensitas dan cakupan
globalisasi ternyata menyentuh hampir seluruh
sendi kehidupan. Tidak hanya bidang ekonomi,
bisnis, budaya, politik, ideologi, melainkan juga telah
menjamah ke tataran systems, processes, actors, dan events. Tulisan ini menyajikan data bahwa tradisi
Gusjigang mampu dipertahankan dengan baik,
sehingga industrialiasasi di Kabupaten Kudus bisa
dijadikan model yang relevan sesuai dengan potensi
dan karakter masyarakatnya. Selain itu gusjigang
sebagai nilai-nilai kearifan lokal dapat dijadikan sebuah
pijakan untuk pengembangan sebuah pembelajaran
yang lebih berkarakter. Kebermaknaan pembelajaran
dengan lingkup kearifan lokal akan menampilkan
sebuah dimensi pembelajaran yang selain memacu
keilmuan seseorang, juga sekaligus bisa mendinamisasi
keilmuan tersebut menjadi kontekstual dan ramah
budaya daerah.
EXPLORING STRATEGIES TO ENHANCE ISLAMIC BANKING’S ROLE TO RAISE CASH WAQF FUNDS
Authors: Khairunisa Rizanti , Akbar Nashr , Devi Abrista
Published: July 2018

Cash Waqf funds has an important role to empower the
economy of Ummah. Unfortunately, the collected cash
waqf fund is still very small compared to its potential
number. Against this background, this research
aims to design systems that may enchance the role of
Islamic banks in cash waqf fund raising. This paper
employed Interpretative Structural Modeling (ISM) by
conducting literature studies and In-depth interviews
with some regulators, practitioners and academicians.
The result shows that experts and practitioners agreed
that the strong legal support on cash waqf is necessary
to enhance the role of Islamic Banks to raise cash waqf
funds. It creates a sense of secure to the stakeholders.
Furthermore, it requires a strong coordination between
Indonesian Waqf Board (BWI), Ministry of Religious
Affairs, Bank Indonesia (BI), Financial Services
Authority (OJK), Nazhir and Islamic Financial
Institutions that may receive cash waqf (LKS-PWU)
in order to boost the role of Islamic Banks. The main
obstacle that must be tacled soon is the lack of education
about cash waqf. 
STRATEGI PEMASARAN DALAM MENINGKATAN USAHA PARA ANGGOTA BAITUL MAAL WAT TANWIL
Authors: Gunawan Karebet
Published: July 2018

Ada berbagai faktor yang menentukan kesuksesan
sebagai wirausaha diantaranya modal usaha,
pasar, kondisi persaingan, dan trend bisnis.
Oleh karena itu, secara teori tidak cukup hanya
mengandalkan insting dalam mengambil
keputusan di dunia bisnis tetapi juga faktor yang
lain. Lebih dari itu, diperlukan suatu kalkulasi
yang komprehensif baik secara kualitatif maupun
kuantitatif dari segala aspek yang berkaitan
dengan usaha yang akan dibuat. orang yang
berusaha atau berwiraswasta agar dapat lebih
bersaing dan memiliki prospek perkembangan
yang bagus, maka sebelum mendirikan orang
yang berusaha atau berwiraswasta sebaiknya
dilakukan manajemen pemasaran usaha terlebih
dahulu.Dalam penelitian kali ini, penulis menggunakan
jenis penelitian field Reseach (Penelitian lapangan)
yaitu penelitian yang mengambil data primer
dari lapangan atau lokasi penelitian tertentu. Jadi
dalam hal ini penelitian yang penulis lakukan
berdasarkan pada data-data lapangan dan
literatur yang berkaitan pada pokok persoalan
yang dibahas. Dalam hal ini peneliti ingin meneliti
tentang strategi pemasaran yang baik.
Permintaan yang didukung oleh kekuatan tenaga
beli disebut permintaan efektif, sedangkan
permintaan yang didasarkan pada kebutuhan saja
disebut sebagai permintaan potensial. Strengths
yang ada dalam pemasaran harus dipertahankan
misalnya sudah punya nama yang baik dan
sudah tahu bagaimana cara meraih konsumen
maka harus dipertahankan. Weakness adalah
mempunyai arti kelemahan yang ada lemah
dalam pengendalian keuangan yang dilakukan
oleh beberapa usaha misalnya masalah keuangan
dimana jarang melakukan pencatatan walaupun
dalam pembuatan nota. Sampai di mana penjual
ingin menawarkan barangnya pada berbagai
tingkat harga ditentukan oleh berbagai faktor.
Functional Status of Women and Their Partners After Childbirth
Authors: ÖZKAN Sevgi , Göral Türkcü Sinem , Kayhan Özlem , Serçekuş Ak Pınar , Sevil Ümran
Published: July 2018

The aim of
this study is to define the changes within the social dimension of the
functional status of women and their partners in the months following the birth
of their child.
A total of 90 participants were included in the study
(45 women and 45 partners). Data were collected in two steps via face-to-face
interviews. The first step involved administration of a personal information
form and the functional status inventories to the women and their partners
between the postpartum sixth and eighth weeks. The second step involved
re-administration of the same functional status inventories to the women and
their partners in the postpartum sixth month. Results from the examination of the functional
status of the women and their partners in the postpartum second and sixth
months showed that there was a significant increase in the areas of household
activities (p=0,000), social and community activities (p=0,000) and self-care
activities (p=0,000) for the women in the sixth month; similarly, for the
fathers,  household activities (p=0,008),
social and community activities (p=0,003) and child care activities (p=0,007)
rose in the sixth month. Furthermore, the study found that certain sociodemographic
variables had an effect on functional status (p=0,000). It is important that nurses and/or
midwives support parents during the pregnancy process, particularly during the
transition into their new roles as women and their partners, and help prepare them
for the changes to occur as they enter into this new period of life.
Organizational development in banks management systems
Authors: Heorhiadi Nelli , Druhov Oleksiy , Vilhutska Roksolana , Bets Mariana , Stoianovskyi Andrii , Folwarski Mateusz
Published: July 2018

Organizational development in banks management systems (ODBMS) is a complex phenomenon of a sustainable and multifunctional nature. The goal of ODBMS is to generate creative ideas and implement changes in order to provide an appropriate level of rational interaction between the ODBMS subjects. It leads to an achievement of the expected economic and managerial results.Organizational changes that are accompanied by organizational development in the BMS can be controlled and spontaneous, positive and negative. The idea of the article is to reveal the methodical aspects of the managed organizational development of the BMS, with expected positive effects. It would be shown that the offered ideas can be used for achieving organizational goals, avoiding the organizational entropy, increasing the creative activity of bank employees, in particular, in developing new banking products, expanding the opportunities of Internet banking, etc.Achieving certain positive effects from the implementation of organizational changes in the BMS requires a high level of managers awareness about the state of implementation of the goals of the bank’s organizational development, the methods of their implementation, factors that affect the achievement of these goals. In this context, fundamental information about the structure and links in the BMS is important as well as operational information that characterizes the level of completeness and implementation quality of the specific banking officers’ duties.In the article the features of ODBMS are solved, based on the application of the provisions of morphological analysis and set theory. The proposed provisions are considered through the prism of two criteria – the level of managerial awareness and predictability of the results of the organizational changes implementation.
Gerencialismo, Internacionalização da educação e o papel da Teach For All no Brasil
Authors: Caetano Maria Raquel , Costa Marilda De Oliveira
Published: July 2018

O artigo examina os avanços da privatização da política educacional na proposta de formação de professores através da ONG “Ensina Brasil” na educação pública brasileira, em especial, na rede estadual de ensino de Mato Grosso. Trata-se da versão brasileira da organização global Teach For All responsável pela internacionalização da ONG Teach For America. Para a análise, utilizaram-se referenciais que abordam a internacionalização de políticas educacionais, o gerencialismo e as mais recentes alterações do capitalismo global, autointitulado capitalismo social. Para tanto, utilizou-se um método que entrecruza dados coletados em sites da web e dados documentais confrontados com discursos e motivações dos principais atores, público e privado, envolvidos nas negociações e o papel reservado a cada sujeito nesse processo. Os resultados apontam para novos desenhos de políticas globais para a educação, fomentada por organizações sociais do grande capital. A educação deixa de ser um direito e torna-se objeto de caridade aos mais pobres ou mesmo um negócio.
Lei 2.639, de 28 de janeiro de 1960
Authors: Araujo Marta Maria
Published: July 2018

No governo de Dinarte de Medeiros Mariz e de José Augusto Varela no Rio Grande do Norte (1956-1961), a Assembleia Legislativa aprovou a Lei n° 2.639, de 28 de janeiro de 1960, criando cargos no Magistério do Estado e transformava o Instituto de Educação do Rio Grande do Norte em Instituto de Educação de Natal constituído pelas seguintes instituições: Escola Normal de Natal, Escola de Aplicação e Jardim de Infância. Ademais, criava o Centro de Formação Educacional do Magistério Primário de Mossoró e o Centro de Formação do Magistério Primário de Caicó com as seguintes composições: Curso Pedagógico, Colégio Estadual de Mossoró/ Colégio Estadual de Caicó, Escola de Aplicação/Artesanato (Caicó) e Jardim de Infância. A importância dessa Lei, de 28 de janeiro de 1960, para a História da Educação do Rio Grande do Norte e do Brasil foi fundamental para a publicação nesta Seção de Documento.
Effect of Dietary Probiotics(Saccharomyces cerevisae)Supplementation on Serum Biochemicals ofTrypanosoma brucei bruceiInfected Rats
Authors: Eze James I. , Didacus Ubochioma E.
Published: July 2018

Background:

Trypanosomosis is an important disease of both humans and animals commonly found in most parts of Africa and South America. Because of their activities, the parasites produce numerous changes in the cellular and biochemical constituents of blood. Also, trypanosomosis cause immunosuppression and also induce lipid peroxidation in the host. Probiotics confer beneficial health benefit to the host such as immune stimulation, protection against pathogens, metabolism, reduced oxidative stress, etc.

Methods:

Thirty (30) adult albino rats were assigned into 5 groups (A – E) of 6 rats each. Groups A, B and C rats were fed feed supplemented with probiotics at 0.08, 0.12 and 0.16 mg per kg respectively. On day 14 on the supplementation (OTS), groups A, B, C and D rats were infected with 1 x 106 trypanosomes intraperitonealy. Group E served as the not infected, not supplemented control.

Results:

The pre-infection supplementation did not vary the serum alanine transaminase (ALT), aspartrate transaminase (AST), urea, creatinine and total protein values of groups A, B and C. However, following infection, the ALT value of group D (infected, not supplemented) was significantly (p<0.05) higher than other groups on day 42 OTS. Also, the AST value of groups A and D were significantly (p<0.05) higher than group E but not with groups B and C on days 42 and 56 on the supplementation. On day 28 OTS, the urea level of group B was significantly (p<0.05) lower than group D whereas on days 42 and 56, group E and groups E and C were significantly (p<0.05) lower than other groups respectively. The serum creatinine level showed increase following infection with groups A and D being significantly (p<0.05) higher than other groups on days 42 and 56 OTS. On day 28 OTS, the total protein value of group A was significantly (p<0.05) lower than group C but not with other groups. By days 42 and 56 OTS, group D showed significantly (p<0.05) lower protein level when compared with other groups. The mean parasitaemia level of group D was significantly higher than other infected infected groups on days 28 and 42 on the supplementation. However, on day 56, the parasitaemia level of all infected groups did not vary (p>0.05).

Conclusion:

The ability of the supplementation to keep serum biochemical values before infection within range, and the subsequent maintenance of the value during most part of the infection were indication that probiotic was not toxic and may play a vital role in management of trypanosomosis.
One-Pot Synthesis of Triazolo-Heterolignans: Biological Evaluation and Molecular Docking Studies as Tubulin Inhibitors
Authors: Reddy Chada Raji , Subbarao Muppidi , Vijaykumar Jonnalagadda , Jadav Surender Singh , Sasane Nilesh , Valleti Reddi Rani , Supriya Bhukya , Ummanni Ramesh
Published: July 2018

Background:

The anti-mitotic activity of podophyllotoxin derivative targeting tubulin enzyme
proved them as strong polymerization inhibitors. The introduction of heteroatom along with different heteroaryl
systems in naturally obtained lignans created a latitude for design of bioactive components. A novel one-pot
sequential propargylation/cycloaddition reaction strategy has been followed to synthesize triazolo-heterolignans.

Objective:

To screen anti-proliferative activity of novel heterolignans and to determine their mode of action.

Method:

SRB assay, Cytotoxicity evaluation, PI uptake for analysis of cell cycle, caspase-3 activity, Western
blot analysis and Immunofluorescence and molecular docking studies.

Results:

SRB assay of synthesised compounds were provided compound 3a and 5f to be highly active among
the synthesized compounds. The Compound 3a showed cell cycle arrest at G2/M phase and 5f arrest the cells at
G1 phase. Compound 5f displayed caspase 3 mediated apoptotic effect at lower levels. Compound 3a and 5f
displayed microtubule disassembly inhibition same as paclitaxel and found to be occupying colchicine binding
site of tubulin, both ligands were depicted π-cation interaction with Lys352 residue and triazole ring accommodated
at the lactone binding site.

Conclusion:

A novel one-pot sequential propargylation/cycloaddition reaction has been developed for the synthesis
of triazolo-heterolignans. Compound 3a and 5f were displayed good cytotoxic activities and found to
inhibit microtubule disassembly. The importance of triazole ring of heterolignans has been studied by molecular
docking experiments and results were compared.
Exploring the Lapse in Druggability: Sequence Analysis, Structural Dynamics and Binding Site Characterization of K-RasG12C Variant, a Feasible Oncotherapeutics Target
Authors: Adeniji Emmanuel A. , Olotu Fisayo A. , Soliman Mahmoud E.S.
Published: July 2018

Background:

The difficulty in druggability of K-Ras variant has presented a challenge in the treatment of cancer diseases associated with its dysfunctionality. Despite the identification of different binding sites, limited information exists in the literature about their characteristics. Therefore, identification, crossvalidation and characterization of its druggable sites would aid the design of chemical compounds that will arrest its dysfunctionality related oncogenesis.

Objective:

This study entails the identification, cross-validation and characterization of K-Ras G12C variant’s binding sites for potential druggability, coupled with the elucidation of alterations in 3D conformations and dynamics.

Method:

Molecular dynamics simulation was carried out on the inactive, the active and the hyperactive K-RasG12Cvariant using the amber software package. The SiteMap software was employed in identifying and characterizing the druggable binding sites while the validation of the binding sites was carried out with the SiteHound and MetaPocket servers.

Results:

Four druggable binding sites were identified, validated and characterized based on physicochemical attributes such as size, volume, degree of enclosure or exposure, degree of contact, hydrophobic/hydrophilic character, hydrophobic/hydrophilic balance and hydrogen-bonding features. Conformational studies also revealed that the K-Ras variant exhibited notable structural instability, increased flexibility and a strongly anticorrelated movement compared to the inactive and active wildtype forms.

Conclusion:

The attributes of the characterized druggable sites will be useful in designing site-specific K-Ras inhibitors for the treatment of K-Ras variant associated cancer diseases.