bluuebunny/crossref_metadata_2025 huggingface dataset:
Geometric Aspects of Shape Optimization
Authors: Plotnikov Pavel I. , Sokolowski Jan
Published: April 2023

We present a review of known results in shape optimization from the point of view of Geometric Analysis. This paper is devoted to the mathematical aspects of the shape optimization theory. We focus on the theory of gradient flows of objective functions and their regularizations. Shape optimization is a part of calculus of variations which uses the geometry. Shape optimization is also related to the free boundary problems in the theory of Partial Differential Equations. We consider smooth perturbations of geometrical domains in order to develop the shape calculus for the analysis of shape optimization problems. There are many applications of such a framework, in solid and fluid mechanics as well as in the solution of inverse problems. For the sake of simplicity we consider model problems, in principle in two spatial dimensions. However, the methods presented are used as well in three spatial dimensions. We present a result on the convergence of the shape gradient method for a model problem. To our best knowledge it is the first result of convergence in shape optimization. The complete proofs of some results are presented in report (Plotnikov and Sokolowski, Gradient flow for Kohn–Vogelius functional).
Cobot uptake in construction: embedding collaborative robots in digital construction processes
Authors: Schöberl Maximilian , Huber Adrian , Kreppold Sebastian , Dirnaichner Johannes , Kessler Stephan , Fottner Johannes
Published: April 2023

The paper at hand investigates the interrelation of automation and collaboration in digital construction processes. Labor shortage, demographic change, and a deficit in productivity motivate automation in construction. While the automation of single tasks is on its way, there is a lack of collaboration between automated equipment and robots along the digital construction process. To foster the development of collaborating robots, definitions and classification criteria for automation and collaboration activities are given. With these criteria at hand, it is possible to classify scientific examples from literature. On top of that, the paper introduces a prototyping framework for automated and collaborative equipment. The framework is thoroughly tested in an earthworks case study consisting of automated and collaborative excavation and compacting of an area. Through the collaboration of an automated excavator and vibratory plate, it is possible to simultaneously execute the ‘excavation’ and ‘compaction’ task, speeding up the overall earthworks process by a factor of almost two. Along with a higher productivity, the high degree of automation allows for safer work, as less workers are exposed to dangerous workspaces and the quality increases through continuous quality checking and integrated documentation of as-built data in BIM models.
Semantic Attack on Disassociated Transaction Data
Authors: AlShuhail Asma , Shao Jianhua
Published: April 2023

Accessing and sharing information, including personal data, has become easier and faster than ever because of the Internet. Therefore, businesses have started to take advantage of the availability of data by gathering, analysing, and utilising individuals’ data for various purposes, such as developing data-driven products and services that can help improve customer satisfaction and retention, and lead to better healthcare and well-being provisions. However, analysing these data freely may violate individuals’ privacy. This has prompted the development of protection methods that can deter potential privacy threats by anonymising data. Disassociation is one anonymisation approach used to protect transaction data. It works by dividing data into chunks to conceal sensitive links between the items in a transaction, but it does not account for semantic relationships that may exist among the items, which adversaries can exploit to reveal protected links. We show that our proposed de-anonymisation approach could break the privacy protection offered by the disassociation method by exploiting such semantic relationships. Our findings indicate that the disassociation method may not provide adequate protection for transactions: up to 60% of the disassociated items can be reassociated, thereby breaking the privacy of nearly 70% of the protected items. In this paper [an extension to our work reported in AlShuhail and Shao (Semantic attack on disassociated transactions. In: Proceedings of the 8th International Conference on information systems security and privacy-ICISSP, INSTICC. SciTePress, pp. 60–72, 2022)], we develop additional techniques to reconstruct transactions, with additional experiments to illustrate the impact of our attacking method.
COVID-19: Physical Activity, Government Restrictions, and Mental Health in the UK and Italy
Authors: Sansone-Pollock Mikaela , Mutrie Nanette , Guerra Cristóbal , Sechi Cristina , Mula Silvana , Calia Clara
Published: April 2023

COVID-19 restrictions could potentially induce poor mental health. This study considers opposing government restrictions on outdoor physical activity in Italy and the UK to evaluate participants’ ability to conduct physical activity, the relationship between physical activity and mental health, and whether restrictions affect mental health as mediated by physical activity. Participants from the UK and Italy self-reported physical activity before and during restrictions, sociodemographic data, and symptoms of depressions, stress, and anxiety during restrictions. Changes in physical activity were analyzed by tests of differences, and relationships between mental health, physical activity, and the effect of country restrictions were evaluated through path analysis. Two hundred sixty-four participants (UK: 57%; Italy: 43%) responded. The model (χ2(2) = .429, p > .05; RMSEA < .08; CFI > .90) confirmed the country’s effect on physical activity. Participants from Italy significantly decreased physical activity while the least active individuals in the UK increased activity during restrictions. Decreases in physical activity had a significant effect on increased reports of stress and depression. Physical activity did not mediate mental health within the countries. Future policies may consider ways to support individuals in maintaining physical activity habits to minimize the possibility of worsening mental health.
Science is more than knowing
Authors: Shan Yafeng
Published: April 2023

Bird’s new book, Knowing Science, provides an exemplar of how to do epistemology and philosophy of science together. While I wholeheartedly appreciate his attempt to bridge the gap between epistemology and philosophy of science and find his project promising, I am not convinced by the central thesis of the book that knowledge plays a central role in science. In this article, I focus on Bird’s epistemic account of scientific progress, which is the view that the nature of scientific progress is the accumulation of scientific knowledge. Contra Bird, I argue that scientific progress cannot be fully characterised as the accumulation of scientific knowledge.
Copyright in the Street
Authors: Bonadio Enrico
Published: April 2023

This book explores how copyright laws are perceived within street art and graffiti subcultures to examine how artists and writers view certain creative aspects of their own practice. Drawing on ethnographic research and fieldwork, the book gives voice to the main actors of these communities and highlights their feelings and opinions toward issues that are increasingly impacting their everyday life and work. It also touches on related and complementary issues, such as the 'gallerisation' or economic exploitation of these forms of art and the curious similarities between the graffiti and advertising worlds. Unique and comprehensive, Copyright on the Street brings the 'voice from the street' into the debate over the legal and non-legal protection of street art and graffiti.
Painting in Renaissance Perugia
Authors: Shaneyfelt Sheri Francis
Published: April 2023

This volume offers the first comprehensive study of painting in Renaissance Perugia from the late fifteenth to the mid- sixteenth centuries. Showcasing works by Perugino, Raphael, and Pintoricchio, as well as less familiar artists who worked in Perugia from ca. 1480–1540, Sheri Shaneyfelt traces  the influence and impact of Perugino's workshop in central Italy over more than a half a century. She demonstrates why Perugia, which has been overlooked in modern scholarship, was such a vital center for the production of early modern Italian art. Shaneyfelt's study also shifts the focus away from the analysis of individual artistic creativity by highlighting the importance and significance of collaboration and workshop production in Renaissance Italy. Interweaving historical and archival evidence with analyses of numerous paintings and drawings, her book, richly illustrated with 115 color illustrations, offers many new insights into the vibrant artistic culture of early modern Perugia.
Dress Cultures in Zambia
Authors: Hansen Karen Tranberg
Published: April 2023

Drawing on half-a-century of research in Zambia and regional scholarship, Karen Tranberg Hansen offers a vibrant history of changing dress practices from the late-colonial period to the present day. Exploring how the dressed body serves as the point of contact between personal, local, and global experiences, she argues that dress is just as central to political power as it is to personal style. Questioning the idea that the West led fashion trends elsewhere, Hansen demonstrates how local dress conventions appropriated western dress influences as Zambian and shows how Zambia contributed to global fashions, such as the colourful Chitenge fabric that spread across colonial trading networks. Brought to life with colour illustrations and personal anecdotes, this book spotlights dress not only as an important medium through which Zambian identities are negotiated, but also as a key reflector and driver of history.
Occupied
Authors: Roshwald Aviel
Published: April 2023

For most of the population of Europe and East and Southeast Asia, the most persistent and significant aspect of their experience of the Second World War was that of occupation by one or more of the Axis powers. In this ambitious and wide-ranging study, Aviel Roshwald brings us the first single-authored, comparative treatment of European and Asian responses to German and Japanese occupation during the war. He illustrates how patriotic, ethno-national, and internationalist identities were manipulated, exploited, reconstructed and reinvented as a result of the wholesale dismantling of states and redrawing of borders. Using eleven case studies from across the two continents, he examines how behavioral choices around collaboration and resistance were conditioned by existing identities or loyalties as well as by short-term cost–benefit calculations, opportunism, or coercion.
Behavioural public policies for the social brain
Authors: Banerjee Sanchayan , Mitra Siddhartha
Published: April 2023

Behavioural public policy is increasingly interested in scaling-up experimental insights to deliver systemic changes. Recent evidence shows some forms of individual behaviour change, such as nudging, are limited in scale. We argue that we can scale-up individual behaviour change by accounting for nuanced social complexities in which human responses to behavioural public policies are situated. We introduce the idea of the ‘social brain’, as a construct to help practitioners and policymakers facilitate a greater social transmission of welfare-improving behaviours. The social brain is a collection of individual human brains, who are connected to other human brains through ‘social cues’, and who are affected by the material and immaterial properties of the physical environment in which they are situated (‘social complex’). Ignoring these cues and the social complex runs the risk of fostering localised behavioural changes, through individual actors, which are neither scalable nor lasting. We identify pathways to facilitate changes in the social brain: either through path dependencies or critical mass shifts in individual behaviours, moderated by the brain's property of social cohesion and multiplicity of situational and dispositional factors. In this way, behavioural changes stimulated in one part of the social brain can reach other parts and evolve dynamically. We recommend designing public policies that engage different parts of the social brain.
Interventions to improve the mental health or mental well-being of migrants and ethnic minority groups in Europe: A scoping review
Authors: Apers Hanne , Van Praag Lore , Nöstlinger Christiana , Agyemang Charles
Published: April 2023

In Europe, migrants and ethnic minority groups are at greater risk for mental disorders compared to the general population. However, little is known about which interventions improve their mental health and well-being and about their underlying mechanisms that reduce existing mental health inequities. To fill this gap, the aim of this scoping review was to synthesise the available evidence on health promotion, prevention, and non-medical treatment interventions targeting migrants and ethnic minority populations. By mapping and synthesising the findings, including facilitators and barriers for intervention uptake, this scoping review provides valuable insights for developing future interventions. We used the PICo strategy and PRISMA guidelines to select peer-reviewed articles assessing studies on interventions. In total, we included 27 studies and synthesised the results based on the type of intervention, intervention mechanisms and outcomes, and barriers and facilitators to intervention uptake. We found that the selected studies implemented tailored interventions to reach these specific populations who are at risk due to structural inequities such as discrimination and racism, stigma associated with mental health, language barriers, and problems in accessing health care. The majority of interventions showed a positive effect on participants’ mental health, indicating the importance of using a tailored approach. We identified three main successful mechanisms for intervention development and implementation: a sound theory-base, systematic adaption to make interventions culturally sensitive and participatory approaches. Moreover, this review indicates the need to holistically address social determinants of health through intersectoral programming to promote and improve mental health among migrants and ethnic minority populations. We identified current shortcomings and knowledge gaps within this field: rigorous intervention studies were scarce, there was a large diversity regarding migrant population groups and few studies evaluated the interventions’ (cost-)effectiveness.
Sethoxydim performance on torpedograss (Panicum repens) and sand cordgrass (Spartina bakeri) as affected by carrier volume and rate
Authors: Sperry Benjamin P. , Enloe Stephen F. , Prince Candice M. , Durham Michael W.
Published: April 2023

Greenhouse experiments were conducted in 2020 to investigate the effects of carrier volume and sethoxydim rate on torpedograss (Panicum repens L.) control and sand cordgrass (Spartina bakeri Merr.) response from a single application. Panicum repens control and biomass reduction generally increased with increasing sethoxydim rates in evaluations at 14, 28, and 42 d after treatment (DAT); however, increasing the rate to 2X the maximum labeled rate did not always result in increased efficacy. In the first experimental run, which consisted of small plants, P. repens control and biomass reductions were largely similar among tested carrier volumes (37, 187, and 935 L ha−1). However, in run 2, which consisted of larger, mature P. repens plants, efficacy increased when carrier volume was reduced. Spartina bakeri injury increased with sethoxydim rate, reaching a maximum of 45% by 42 DAT. However, no differences in S. bakeri injury among carrier volumes were observed at 14 and 28 DAT evaluations. Spartina bakeri aboveground biomass reductions were also largely driven by sethoxydim rate increases rather than reduced carrier volumes, reaching 40% to 50% reduction in initial aboveground biomass. However, S. bakeri belowground biomass was 20% to 32% greater in treatments applied at 37 or 187 L ha−1 compared with those at 935 L ha−1. Overall, these data suggest that selective P. repens control with sethoxydim may be enhanced through reducing carrier volumes from 935 L ha−1 and that native, perennial, caespitose grasses may exhibit greater tolerance to sethoxydim compared with the rhizomatous P. repens. Future research should further test these hypotheses under field conditions at operational scales.
Policing, citizenship and the civil courts: how increased settlement of civil claims has impacted police accountability
Authors: Torrible Clare
Published: April 2023

It is recognised that civil litigation has a place within the police accountability infrastructure. However, the role of actions against the police for wrongful arrest, false imprisonment, assault, and malicious prosecution (hereafter police actions) is underexplored. Taking citizenship as its analytical frame, this paper probes the relationship between police actions and the police complaints and discipline system over the last 60 years. Its primary focus is the Court of Appeal decision Thompson v Commissioner of Police of the Metropolis, Hsu v Same [1998] QB 498 (Thompson). Here the potential for police actions to expose questionable police responses to officer misconduct, and failings in external oversight mechanisms, came into conflict with the drive towards proportionate civil justice. In prioritising the latter, Thompson increased police autonomy over settlement of police actions, thereby deprioritising the role of the courts in demarcating the limits of state interference with citizens’ rights. It is not suggested that Thompson should be overruled. Instead, it is contended that recognising the impact of the decision on subsequent reforms to police accountability processes and contemporary conceptions of the police-citizen relationship is crucial to understanding the roots of current disquiet concerning police accountability (and therefore to the development of meaningful reforms).
Incapacitous patients, assisted reproductive technology, and the importance of informed consent
Authors: Cherkassky Lisa
Published: April 2023

The principle of self-determination has gained significant judicial support over the last three decades, and the choice to procreate using assisted reproductive technology is a clear example of our right to choose a treatment that enhances our personal lives. The Human Fertilisation and Embryology Act 1990 (as amended in 2008) stipulates that each party must give written, informed consent to ensure that our reproductive materials are used within strict parameters. However, the growing number of posthumous conception cases in several jurisdictions has raised concerns, particularly in situations where gametes are extracted from incapacitous patients without their consent, leading to posthumous parenthood. The landmark case of Y v A Healthcare NHS Trust [2018] EWCOP 18 caused significant concern when it authorised the retrieval, storage and use of sperm from a suspected brain stem dead man for procreative purposes under the Mental Capacity Act 2005. It has never been known to be in the ‘best interests’ of a patient who lacks capacity to procreate in English law, and the consequences of this decision could be highly significant, raising questions about the exploitation of incapacitous patients and the misuse of genetic material. The decision has since been confirmed as the correct approach by the Court of Protection in Re X (Catastrophic Injury: Collection and Storage of Sperm) [2022] EWCOP 48, and a public consultation has now been opened by the Human Fertilisation and Embryology Authority. This paper examines the rigorous consent regime of the 1990 Act and the ethical complexities of retrieving gametes from incapacitous patients for procreative purposes. It will be determined that the 1990 Act's preference for a rigorous consent regime for public policy reasons is appropriate, and any alternative forms of consent could open a slippery slope to the unethical use of vulnerable individuals for their reproductive materials.
A vaccination romance: Rider Haggard’s Dr. Therne (1898) in the vaccination debate
Authors: Broad Juliana
Published: April 2023

Henry Rider Haggard, the famed author of adventure romances, wrote the novel Dr. Therne (1898) in response to weakening compulsory smallpox vaccination laws, thus entering one of the most heated debates of the late nineteenth century. With Dr. Therne, Haggard aimed to intervene in the lives of the many working-class anti-vaccinationists who, from the 1850s onwards, mobilised to evade what they perceived as a gross – and targeted – extension of state power at the expense of individual rights. Recovering the novel, which has not yet received scholarly attention from historians of medicine, reveals the way fiction was called upon to change minds during a crucial period of Victorian medicine, one that witnessed a climactic shift in public health intervention. This article will examine the reception of Dr. Therne in various print media – middle-class London papers, medical journals and working-class, anti-vaccinationist publications – to consider some new dynamics of the debate which the disagreement over Haggard’s polemic exposes, including the perceived power of fiction (when properly priced and distributed) to change minds, and the contested role of the evangelical press. Additionally, a discussion of the different iterations of Dr. Therne, and a look at an exceptional anti-vaccinationist response in the form of a competing novel, illustrates that pro- and anti-vaccinationists alike contributed to a moment in late Victorian society when the role of fiction was considered a worthy contender in a debate ostensibly about fact.
Post-operative vestibular and equilibrium evaluation in patients with cholesteatoma-induced labyrinthine fistulas
Authors: Peng Q , Liu K , Wang M , Zhou C , Zhang S , Liu Y , Xie B
Published: April 2023

Objective

This study aimed to compare the pre- and post-operative vestibular and equilibrium functions of patients with cholesteatoma-induced labyrinthine fistulas who underwent different management methods.

Methods

Data from 49 patients with cholesteatoma-induced labyrinthine fistulas who underwent one of three surgical procedures were retrospectively analysed. The three management options were fistula repair, obliteration and canal occlusion.

Results

Patients underwent fistula repair (n = 8), canal occlusion (n = 18) or obliteration procedures (n = 23). Patients in the fistula repair and canal occlusion groups suffered from post-operative vertigo and imbalance, which persisted for longer than in those in the obliteration group. Despite receiving different management strategies, all patients achieved complete recovery of equilibrium functions through persistent efforts in rehabilitation exercises.

Conclusion

Complete removal of the cholesteatoma matrix overlying the fistula is reliable for preventing iatrogenic hearing deterioration due to unremitting labyrinthitis. Thus, among the three fistula treatments, obliteration is the optimal method for preserving post-operative vestibular functions.
NT-proBNP levels as a predictor of higher left ventricular end-diastolic pressure in children with small perimembranous ventricular septal defect
Authors: Apandi Putria R. , Djer Mulyadi M. , Kuswiyanto Rahmat B. , Wijaya Elrika A. , Artiko Bagus , Rahayuningsih Sri E.
Published: April 2023

Introduction:

The decision to close small ventricular septal defect is still controversial. Previous study showed that ventricular dysfunction in adulthood is correlated with small perimembranous ventricular septal defect. N terminal pro B-type natriuretic peptide (NT-proBNP) is a neurohormone secreted primarily from the ventricles in response to increased left and right ventricular pressure and volume load. The left ventricular end-diastolic pressure will reflect ventricular performance. This study aimed to evaluate the correlation between left ventricular end-diastolic pressure and the NT-proBNP in children with small perimembranous ventricular septal defect.

Materials and Methods:

Level of NT-proBNP in 41 patients with small perimembranous ventricular septal defect was measured before transcatheter closure procedure. We also measured the left ventricular end-diastolic pressure in each patients during catheterisation. We investigated the value of NT-proBNP in patients with small perimembranous ventricular septal defect and its correlation with the level of left ventricular end-diastolic pressure

Result:

We found positive correlation between NT-proBNP and left ventricular end-diastolic pressure (r = 0.278, p = 0.046). The median of NT-proBNP at left ventricular end-diastolic pressure < 10 was lower than at left ventricular end-diastolic pressure ≥ 10 (0.87 ng/ml versus 1.83 ng/ml, p = 0.023). The results of the NT-proBNP diagnostic test for predicting left ventricular end-diastolic pressure ≥ 10 using Receiver Operating Characteristic (ROC) analysis showed the area under the curve value of 0.715 (95% CI: 0.546–0.849). The cut-off value >0.99 ng/ml of NT-proBNP has 75.0% sensitivity and 72.2% specifity.

Conclusion:

Level of NT-proBNP higher than 0.99 ng/ml was correlated significantly with left ventricular end-diastolic pressure ≥10 in children with small perimembranous ventricular septal defect.
Coronary artery dilation associated with bicuspid and unicuspid aortic valve disease in children: a series of 17 patients
Authors: Robinson David L. , Minich L. LuAnn , Menon Shaji C. , Ou Zhining , Eckhauser Aaron W. , Ware Adam L.
Published: April 2023

Introduction:

Coronary artery dilation associated with bicuspid/unicuspid aortic valves is described in adults with limited data in children. We aimed to describe the clinical course of children with bicuspid/unicuspid aortic valves and coronary dilation including coronary Z-score changes over time, association of coronary changes with aortic valve anatomy/function, and complications.

Materials and methods:

Institutional databases were searched for children ≤18 years with both bicuspid/unicuspid aortic valves and coronary dilation (1/2006-6/2021). Kawasaki disease and isolated supra-/subvalvar aortic stenosis were excluded. Statistics were descriptive with associations measured by Fisher’s exact test and overlapping 83.7% confidence intervals.

Results:

Of 17 children, bicuspid/unicuspid aortic valve was diagnosed at birth in 14 (82%). Median age at coronary dilation diagnosis was 6.4 years (range: 0-17.0). Aortic stenosis was present in 14 (82%) [2 (14%) moderate, 8 (57%) severe]; 10 (59%) had aortic regurgitation; 8 (47%) had aortic dilation. The right coronary was dilated in 15 (88%), left main in 6 (35%), and left anterior descending in 1 (6%) with no relationship between leaflet fusion pattern or severity of aortic regurgitation/stenosis on coronary Z-score. Follow-up evaluations were available for 11 (mean 9.3 years, range 1.1–14.8) with coronary Z-scores increasing in 9/11 (82%). Aspirin was used in 10 (59%). There were no deaths or coronary artery thrombosis.

Discussion:

In children with bicuspid/unicuspid aortic valves and coronary dilation, the right coronary artery was most frequently involved. Coronary dilation was observed in early childhood and frequently progressed. Antiplatelet medication use was inconsistent, but no child died nor developed thrombosis.
Cardiac side effects of propranolol in infants treated for infantile haemangiomas
Authors: Maliqari Numila , Duka Enkeleda , Kuneshka Loreta
Published: April 2023

Objectives:

This study aims to add proof to the safety profile of propranolol as first-line choice in treating infantile haemangiomas, in particular related to its cardiac side effects the main hindering reason for parents and physicians to start and comply with treatment.

Method:

This is a prospective observational and analytic study with a sample of 476 patients diagnosed with infantile haemangioma and treated with systemic propranolol during the time interval January 2011 to December 2021. We studied clinical propranolol adverse events experienced in hospital or outpatient and measured the impact of propranolol on blood pressure and heart rate.

Results:

This study showed that symptomatic adverse events caused by propranolol were mild and severe adverse events were rare. The most common clinical side effects were paleness, sweating, reduced feeding, and agitation. Only in 28 (5.9%) cases these symptoms were severe enough to review treatment, 1.8% had severe respiratory symptoms, 2.7% experienced hypoglycaemia, and 1.2% had heart-related symptoms. Mean blood pressure reduction with treatment was statistically significant only after achieving the maintenance dose 2 mg/kg body weight. Blood pressure under the 5th percentile was registered in 2.9% of cases, but only four patients had symptomatic hypotension. While heart rate reduction was noticed with the first dose, only two experienced symptomatic bradycardia.

Conclusion:

We conclude that propranolol is not only an excellent drug in treating infantile haemangioma, but it has also a very safe profile, with mild side effects and very rare severe cardiac adverse events, easily overcome with treatment interruption.
Association of breakfast skipping with habitual dietary intake and BMI in female rotating shift workers
Authors: Yoshizaki Takahiro , Komatsu Taiki , Tada Yuki , Togo Fumiharu
Published: April 2023

Objective:

Higher BMI, lower quality of diet and a higher percentage of breakfast-skippers have been reported among rotating shift (RS) workers compared with day shift (DS) workers. As such, this study examined the association between breakfast skipping, habitual food consumption and BMI in RS workers.

Design:

Japanese nurses were studied using a self-administered questionnaire that assessed the height, weight, breakfast consumption habits, dietary consumption, physical activity, sleep habits, chronotype and demographic characteristics of the participants.

Setting:

A cross-sectional study was conducted in a population of nurses in Japan. Dietary and health-related questionnaires were mailed to 5536 nurses aged 20–59 years, working at 346 institutions.

Participants:

A total of 3646 nurses at 274 institutions responded to the questionnaire. After removing those who met the exclusion criteria, 2450 participants were included in the statistical analysis.

Results:

The RS breakfast-skippers had lower total energy intake, diet quality and higher BMI than DS workers, whereas the RS breakfast-consumers had a higher total energy intake and BMI than the DS workers. In the RS workers, breakfast skipping on the days of DS and the end days of evening/night shift was associated with a poorer diet quality. Additionally, breakfast skipping on the days of DS was positively associated with BMI, independent of the total energy intake and diet quality.

Conclusions:

Breakfast skipping on workdays may contribute to a difference in dietary intake and BMI between RS workers and DS workers and may increase BMI in RS workers, independent of dietary intake.
Beaver Pond Geomorphology Influences Pond Nitrogen Retention and Denitrification
Authors: Murray Desneiges , Neilson Bethany T. , Brahney Janice
Published: April 2023

Beaver ponds are increasingly promoted as a strategy for physical stream restoration, and more recently recognized as natural solutions for excess nonpoint source pollutants, such as nitrogen (N). Beaver ponds facilitate N transformations on the streamscape by increasing sediment‐water interactions and creating low and high redox conditions in close proximity. Because beaver ponds vary widely in their geomorphology, the spatial extent of morphological units should dictate the degree of biogeochemical processing. We explore the role of beaver pond geomorphic units in facilitating sediment N transformations using a sediment mass balance approach. We quantified input, output, and transformation of N species within the sediments and water of the riffle, backwater, and margin geomorphic units of a beaver pond in Northern Utah. Our interpretations were supplemented using sediment oxygen demand (SOD) and sediment C and N stable isotopes. The backwater performed most of the biogeochemical work, including increased sedimentation (2.1 g N m−2d−1), ammonification (1.3 g N m−2d−1), nitrification (0.07 g N m−2d−1), and denitrification (0.1 g N2 m−2 d−1), the latter facilitated by high sediment OM (14%) and SOD (−0.95 ± 0.2 g O2 m−2 d−1). Backwater sediment isotopes, supported by N flux measurements, indicated increased benthic microbial activity and denitrification. The margin and backwater surface sediments had low C:N ratios, indicating sediment input from autochthonous production. These findings suggest the representation of geomorphic units in a beaver pond may predict whether the pond can facilitate N removal through sediment sequestration and denitrification.
Burnout and Coping Strategies in Pediatric and Neonatal Intensive Care Staff
Authors: Butcher Isabelle , Morrison Rachael , Balogun Omobolanle , Duncan Heather , St Louis Kate , Webb Sarah , Shaw Rachel
Published: April 2023

Objective:

Staff in pediatric and neonatal intensive care units (PICU and NICU) experience high rates of burnout due to the highly stressful environment. There is growing literature describing stress and burnout, but to date, no review of the evidence specific to pediatric and neonatal intensive care. For the development of interventions to reduce and prevent burnout, there needs to be a better understanding of this evidence. Little is known about coping strategies employed by critical care staff; it is important to collate and critique this literature to inform interventions. The objective of this systematic review was to examine burnout occurrence and coping strategies among staff working in PICU and NICU.

Methods:

A systematic search of Web of Science (WoS), Scopus, Medline, AMED, PsycINFO, CINAHL, Nice Evidence, and EMBASE was conducted following PRISMA guidelines.

Results:

Studies measuring burnout and/or coping in PICU and NICU were included in the review. Twenty-two studies met the inclusion criteria, the majority of which used a quantitative cross-sectional design. Of the included studies, 14 measured burnout, and 17 measured coping.

Conclusion:

Staff working in pediatric and neonatal intensive care settings experience high rates of burnout. While staff may have the ability to use coping strategies, often time and lack of awareness mean they don't. Psychologically informed interventions are required to prevent burnout and to provide staff with the tools and resources to develop healthy coping strategies in order to boost their well-being. Those interventions must then be formally evaluated to determine their impact on staff psychological outcomes.

Implications for Impact Statement

This work offers insight into avenues for future research to further describe the nature of burnout and to identify the predictors of successful coping. The literature review shows that there is variation in the way burnout and compassion fatigue are measured; working toward a consensus for a “gold standard” measurement would help synthesize the evidence. Coping is less well described and measures are not always appropriate; further work is required to identify and measure the impact of coping strategies to develop the evidence base.
Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial
Authors: Yan Xiang , Li Xia , Liu Bingwen , Huang Jiaqi , Xiang Yufei , Hu Yuhang , Tang Xiaohan , Zhang Ziwei , Huang Gan , Xie Zhiguo , Zhou Houde , Liu Zhenqi , Wang Xiangbing , Leslie Richard David , Zhou Zhiguang
Published: April 2023

Disease modifying therapies aiming to preserve β-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking. Here, we conducted a multi-centre, randomized, controlled trial to assess the β-cell preservation effects of saxagliptin alone and saxagliptin combined with vitamin D as adjunctive therapies in adult-onset autoimmune type 1 diabetes. In this 3-arm trial, 301 participants were randomly assigned to a 24-month course of the conventional therapy (metformin with or without insulin) or adjunctive saxagliptin or adjunctive saxagliptin plus vitamin D to the conventional therapy. The primary endpoint was the change from baseline to 24 months in the fasting C-peptide. The secondary endpoints included the area under the concentration-time curve (AUC) for C-peptide level in a 2-h mixed-meal tolerance test, glycemic control, total daily insulin use and safety, respectively. The primary endpoint was not achieved in saxagliptin plus vitamin D group (P = 0.18) and saxagliptin group (P = 0.26). However, compared with the conventional therapy, 2-h C-peptide AUC from 24 months to baseline decreased less with saxagliptin plus vitamin D (-276 pmol/L vs. -419 pmol/L; P = 0.01), and not to the same degree with saxagliptin alone (-314 pmol/L; P = 0.14). Notably, for participants with higher glutamic acid decarboxylase antibody (GADA) levels, the decline of β-cell function was much lower in saxagliptin plus vitamin D group than in the conventional therapy group (P = 0.001). Insulin dose was significantly reduced in both active treatment groups than in the conventional therapy group despite all groups having similar glycemic control. In conclusion, the combination of saxagliptin and vitamin D preserves pancreatic β-cell function in adult-onset autoimmune type 1 diabetes, an effect especially efficacious in individuals with higher GADA levels. Our results provide evidence for a novel adjunct to insulin and metformin as potential initial treatment for adult-onset type 1 diabetes. (ClinicalTrials.gov identifier: NCT02407899).
Ultra-stable and tough bioinspired crack-based tactile sensor for small legged robots
Authors: Kim Taewi , Hong Insic , Kim Minho , Im Sunghoon , Roh Yeonwook , Kim Changhwan , Lim Jongcheon , Kim Dongjin , Park Jieun , Lee Seunggon , Lim Daseul , Cho Junggwang , Huh Seokhaeng , Jo Seung-Un , Kim ChangHwan , Koh Je-Sung , Han Seungyong , Kang Daeshik
Published: April 2023

For legged robots, collecting tactile information is essential for stable posture and efficient gait. However, mounting sensors on small robots weighing less than 1 kg remain challenges in terms of the sensor’s durability, flexibility, sensitivity, and size. Crack-based sensors featuring ultra-sensitivity, small-size, and flexibility could be a promising candidate, but performance degradation due to crack growing by repeated use is a stumbling block. This paper presents an ultra-stable and tough bio-inspired crack-based sensor by controlling the crack depth using silver nanowire (Ag NW) mesh as a crack stop layer. The Ag NW mesh inspired by skin collagen structure effectively mitigated crack propagation. The sensor was very thin, lightweight, sensitive, and ultra-durable that maintains its sensitivity during 200,000 cycles of 0.5% strain. We demonstrate sensor’s feasibility by implementing the tactile sensation to bio-inspired robots, and propose statistical and deep learning-based analysis methods which successfully distinguished terrain type.
Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson’s disease dementia brain
Authors: Scholefield Melissa , Church Stephanie J. , Taylor George , Knight David , Unwin Richard D. , Cooper Garth J. S.
Published: April 2023

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, most commonly characterised by motor dysfunction, but also with a high prevalence of cognitive decline in the decades following diagnosis—a condition known as Parkinson’s disease dementia (PDD). Although several metabolic disruptions have been identified in PD, there has yet to be a multi-regional analysis of multiple metabolites conducted in PDD brains. This discovery study attempts to address this gap in knowledge. A semi-targeted liquid chromatography–mass spectrometry analysis of nine neuropathologically-confirmed PDD cases vs nine controls was performed, looking at nine different brain regions, including the cingulate gyrus, cerebellum, hippocampus, motor cortex, medulla, middle temporal gyrus, pons, substantia nigra and primary visual cortex. Case–control differences were determined by multiple t-tests followed by 10% FDR correction. Of 64 identified analytes, 49 were found to be altered in at least one region of the PDD brain. These included metabolites from several pathways, including glucose and purine metabolism and the TCA cycle, with widespread increases in fructose, inosine and ribose-5-phosphate, as well as decreases in proline, serine and deoxyguanosine. Higher numbers of alterations were observed in PDD brain regions that are affected during earlier α-synuclein Braak stages—with the exception of the cerebellum, which showed an unexpectedly high number of metabolic changes. PDD brains show multi-regional alterations in glucose and purine metabolic pathways that reflect the progression of α-synuclein Braak staging. Unexpectedly, the cerebellum also shows a high number of metabolic changes.
An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection
Authors: Bollman Brooke , Nunna Naveen , Bahl Kapil , Hsiao Chiaowen Joyce , Bennett Hamilton , Butler Scott , Foreman Bryant , Burgomaster Katherine E. , Aleshnick Maya , Kong Wing-Pui , Fisher Brian E. , Ruckwardt Tracy J. , Morabito Kaitlyn M. , Graham Barney S. , Dowd Kimberly A. , Pierson Theodore C. , Carfi Andrea
Published: April 2023

Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of congenital disease during a major outbreak in the Americas in 2016. Vaccine design strategies relied on limited available isolate sequence information due to the rapid response necessary. The first-generation ZIKV mRNA vaccine, mRNA-1325, was initially generated and, as additional strain sequences became available, a second mRNA vaccine, mRNA-1893, was developed. Herein, we compared the immune responses following mRNA-1325 and mRNA-1893 vaccination and reported that mRNA-1893 generated comparable neutralizing antibody titers to mRNA-1325 at 1/20th of the dose and provided complete protection from ZIKV challenge in non-human primates. In-depth characterization of these vaccines indicated that the observed immunologic differences could be attributed to a single amino acid residue difference that compromised mRNA-1325 virus-like particle formation.
Tissue memory relies on stem cell priming in distal undamaged areas
Authors: Levra Levron Chiara , Watanabe Mika , Proserpio Valentina , Piacenti Gabriele , Lauria Andrea , Kaltenbach Stefan , Tamburrini Annalaura , Nohara Takuma , Anselmi Francesca , Duval Carlotta , Elettrico Luca , Donna Daniela , Conti Laura , Baev Denis , Natsuga Ken , Hagai Tzachi , Oliviero Salvatore , Donati Giacomo
Published: April 2023

Epithelial cells that participated in wound repair elicit a more efficient response to future injuries, which is believed to be locally restricted. Here we show that cell adaptation resulting from a localized tissue damage has a wide spatial impact at a scale not previously appreciated. We demonstrate that a specific stem cell population, distant from the original injury, originates long-lasting wound memory progenitors residing in their own niche. Notably, these distal memory cells have not taken part in the first healing but become intrinsically pre-activated through priming. This cell state, maintained at the chromatin and transcriptional level, leads to an enhanced wound repair that is partially recapitulated through epigenetic perturbation. Importantly wound memory has long-term harmful consequences, exacerbating tumourigenesis. Overall, we show that sub-organ-scale adaptation to injury relies on spatially organized memory-dedicated progenitors, characterized by an actionable cell state that establishes an epigenetic field cancerization and predisposes to tumour onset.
Nationwide health, socio-economic and genetic predictors of COVID-19 vaccination status in Finland
Authors: Hartonen Tuomo , Jermy Bradley , Sõnajalg Hanna , Vartiainen Pekka , Krebs Kristi , Vabalas Andrius ,   FinnGen,   Estonian Biobank Research Team, Metspalu Andres , Esko Tõnu , Nelis Mari , Hudjashov Georgi , Leino Tuija , Nohynek Hanna , Sivelä Jonas , Mägi Reedik , Daly Mark , Ollila Hanna M. , Milani Lili , Perola Markus , Ripatti Samuli , Ganna Andrea
Published: April 2023

Understanding factors associated with COVID-19 vaccination can highlight issues in public health systems. Using machine learning, we considered the effects of 2,890 health, socio-economic and demographic factors in the entire Finnish population aged 30–80 and genome-wide information from 273,765 individuals. The strongest predictors of vaccination status were labour income and medication purchase history. Mental health conditions and having unvaccinated first-degree relatives were associated with reduced vaccination. A prediction model combining all predictors achieved good discrimination (area under the receiver operating characteristic curve, 0.801; 95% confidence interval, 0.799–0.803). The 1% of individuals with the highest predicted risk of not vaccinating had an observed vaccination rate of 18.8%, compared with 90.3% in the study population. We identified eight genetic loci associated with vaccination uptake and derived a polygenic score, which was a weak predictor in an independent subset. Our results suggest that individuals at higher risk of suffering the worst consequences of COVID-19 are also less likely to vaccinate.
Electrical control of hybrid exciton transport in a van der Waals heterostructure
Authors: Tagarelli Fedele , Lopriore Edoardo , Erkensten Daniel , Perea-Causín Raül , Brem Samuel , Hagel Joakim , Sun Zhe , Pasquale Gabriele , Watanabe Kenji , Taniguchi Takashi , Malic Ermin , Kis Andras
Published: April 2023

Interactions between out-of-plane dipoles in bosonic gases enable the long-range propagation of excitons. The lack of direct control over collective dipolar properties has so far limited the degrees of tunability and the microscopic understanding of exciton transport. In this work we modulate the layer hybridization and interplay between many-body interactions of excitons in a van der Waals heterostructure with an applied vertical electric field. By performing spatiotemporally resolved measurements supported by microscopic theory, we uncover the dipole-dependent properties and transport of excitons with different degrees of hybridization. Moreover, we find constant emission quantum yields of the transporting species as a function of excitation power with radiative decay mechanisms dominating over nonradiative ones, a fundamental requirement for efficient excitonic devices. Our findings provide a complete picture of the many-body effects in the transport of dilute exciton gases, and have crucial implications for studying emerging states of matter such as Bose–Einstein condensation and optoelectronic applications based on exciton propagation.