bluuebunny/crossref_metadata_2025 huggingface dataset:
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state
Authors: Erkan‐Candag Hazel , Clarke Amy , Tiapko Oleksandra , Gsell Mathias AF , Stockner Thomas , Groschner Klaus
Published: May 2022

Coordination of lipids within transient receptor potential canonical channels (TRPCs) is essential for their Ca2+ signaling function. Single particle cryo‐EM studies identified two lipid interaction sites, designated L1 and L2, which are proposed to accommodate diacylglycerols (DAGs). To explore the role of L1 and L2 in TRPC3 function, we combined structure‐guided mutagenesis and electrophysiological recording with molecular dynamics (MD) simulations. MD simulations indicate rapid DAG accumulation within both L1 and L2 upon its availability within the plasma membrane. Electrophysiological experiments using a photoswitchable DAG‐probe reveal potentiation of TRPC3 currents during repetitive activation by DAG. Importantly, initial DAG exposure generates a subsequently sensitized channel state that is associated with significantly faster activation kinetics. TRPC3 sensitization is specifically promoted by mutations within L2, with G652A exhibiting sensitization at very low levels of active DAG. We demonstrate the ability of TRPC3 to adopt a closed state conformation that features partial lipidation of L2 sites by DAG and enables fast activation of the channel by the phospholipase C‐DAG pathway.
Estudio de la biota de ratas de bioterio: caracterización de Escherichia coli comensal
Authors: Vega-Manriquez Xochitl , Hernández-Fraga Omar , Pinos-Rodríguez Juan Manuel , Martínez-Benítez Cesar , Hernández-Chiñas Ulises , Eslava-Campos Carlos
Published: May 2022

El objetivo del trabajo fue caracterizar cepas de E. coli aisladas de Rattus norvegicus pertenecientes a un bioterio de nivel 1. Se tomaron muestras de heces a 13 ratas. Se seleccionaron cinco colonias al azar del crecimiento primario del cultivo de cada individuo muestreado. Se realizaron pruebas bioquímicas y en las cepas que fueron identificadas como E. coli se estableció el patotipo y el filogrupo por medio de la técnica de PCR. Además, se realizaron pruebas para la formación de biopelículas y la susceptibilidad antimicrobiana. El 65% (26/40) de las cepas aisladas correspondieron a E. coli. El análisis mediante PCR mostró que todas se agruparon en el filogrupo B2. Seis de las cepas de E. coli presentaban resistencia a nitrofurantoina (23%), cuatro fueron resistentes a ampicilina (15%) y en tres cepas se observó resistencia a cefozolina (11%). Ninguna mostró la formación de biopelículas, ni la amplificación de genes relacionados a algún patotipo. Los resultados denotan que E. coli perteneciente a la biota de ratas de bioterio presenta resistencia a antibióticos y la presencia de los genes chuA y yjaA que incluyen a las cepas en el filogrupo B2 relacionado a enfermedades extraintestinales.
Seroprevalencia de anticuerpos contra el virus de la Rinotraqueitis Infecciosa Bovina en ganaderías de crianza extensiva en tres distritos de Ayacucho, Perú
Authors: Vilchez-Tineo Caroline , Morales-Cauti Siever
Published: May 2022

El objetivo del estudio fue determinar la seroprevalencia de anticuerpos contra el virus de la rinotraqueitis infecciosa bovina (IBR) en los distritos de Coracora, Chumpi y Pullo de la provincia de Parinacochas, Ayacucho, durante 2018. Se obtuvieron 460 muestras de sangre de bovinos, machos y hembras. mayores de 4 meses criados bajo un sistema de crianza extensiva. Las muestras fueron analizadas con un kit comercial de ELISA indirecto. El 59.56 + 4.45% (282/460) de las muestras presentaron anticuerpos frente al virus de IBR; siendo Pullo el distrito con mayor seroprevalencia (71.58 + 4.09%). Asimismo, la categoría zootécnica y la raza presentaron asociación estadística significativa (p<0.05) frente al virus de la IBR.
Efectos de la flor de marigold (Tagetes erecta) y el rizoma de cúrcuma (Curcuma longa) como fuentes de carotenoides sobre el rendimiento productivo y las características de carcasa de pollos doble propósito en la fase de finalización
Authors: Paredes Manuel , Quispe Keiko
Published: May 2022

El objetivo del estudio fue determinar el efecto de la flor de marigold (Tagetes erecta) y el rizoma de cúrcuma (Curcuma longa) como fuentes de carotenoides sobre el desempeño productivo del pollo doble propósito y características de carcasa. Se trabajó con 120 pollos de ambos sexos desde 84 hasta 112 días de edad, asignados a seis tratamientos (cinco repeticiones por tratamiento y cuatro aves por repetición), bajo arreglo factorial, con dos factores: sexo (machos y hembras) y fuentes de carotenoides (control, marigold y cúrcuma). Todos los pollos recibieron el mismo alimento concentrado, variando las fuentes de carotenoides. La flor de marigold y el rizoma de cúrcuma no mejoraron el rendimiento productivo de los pollos ni generaron efectos adversos en el crecimiento. La cúrcuma produjo mayor tonalidad rojiza en la carcasa que el marigold; sin embargo, la flor de marigold provocó mayor amarillamiento de la piel de pechuga. El rizoma de cúrcuma redujo la acumulación de grasa abdominal en la carcasa, con menor masa de hígado con relación al peso corporal del ave.
Global Substrate Mapping and Targeted Ablation with Novel Gold-tip Catheter in De Novo Persistent AF
Authors: Pope Michael TB , Betts Timothy R
Published: May 2022

Results from catheter ablation for persistent AF are suboptimal, with no strategy other than pulmonary vein isolation showing clear benefit. Recently employed empirical strategies beyond pulmonary vein isolation involve widespread atrial ablation in all patients and do not take into account patient-specific differences in AF mechanisms or phenotype. Charge density mapping using the non-contact AcQMap system (Acutus Medical) allows visualisation of whole-chamber activation during AF and reveals localised patterns of complex activation thought to represent important mechanisms for AF maintenance that can be targeted with focal ablation. In this review, the authors outline the fundamentals of this technology, the initial data exploring the mechanistic role of activation patterns seen and the application to ablation of persistent AF.
Cosmopolitismo e decolonialidade
Authors: Costa Antônio Carlos da Rocha
Published: May 2022

Neste artigo, explicitamos os sentidos políticos das propostas de cosmopolitismo e de decolonialidade tal como elas foram respectivamente apresentadas por Immanuel Kant, no texto Ideia de uma História Universal desde um Ponto de Vista Cosmopolita e por Aníbal Quijano, no artigo “Colonialidade e Modernidade/Racionalidade”. Com base na explicitação desses sentidos, focalizamos então, desde o ponto de vista do processo de equilibração das relações internacionais, a questão da interdependência das duas propostas, isto é: (1) a impossibilidade de cada proposta ser pensada completamente sem a outra; (2) a possibilidade de uma coordenação positiva entre as duas propostas, permitindo que cada uma contribua para a concretização da outra.
Relato de experiência: programa de aperfeiçoamento didático em patologia geral e sistemas na pandemia COVID-19
Authors: Salles Débora , De Souza Santos Debora , Cristina de Moraes Malinverni Andréa
Published: May 2022

A combinação de diversos elementos leva a uma boa qualidade de ensino, dentre os quais pode-se destacar a preparação dos discentes e docentes. O estágio em docência vai muito além de aprender a ministrar uma aula, pois o professor que se sente comprometido com seu aluno faz uso de recursos que proporcionarão sua motivação e aprendizagem real.  O Programa de Aperfeiçoamento Didático é um Programa Institucional da Universidade Federal de São Paulo que atende a política de formação docente de pós-graduandos de Programas de Pós-Graduação , tendo como objetivo o desenvolvimento para a prática docente em todos os seus aspectos. O objetivo deste trabalho é relatar a experiência deste estágio em docência na unidade curricular de Patologia, para o segundo ano de graduação do curso de bacharel em Enfermagem da Escola Paulista de Enfermagem, Universidade Federal de São Paulo. A atuação dos estagiários envolveu preparar e lecionar aulas supervisionadas, além de realizar e tutoria para a apresentação dos trabalhos finais da disciplina, entre outras atividades. Foram obtidos ótimos resultados quanto à interação entre estagiários e alunos, e o processo foi uma experiência ímpar, pois os estagiários passaram de uma posição de “recebedor” para “fornecedor” do saber, tendo como desafio democratizar o conhecimento.
Scenarios for vocational education and training in Europe in the 21st century
Authors: Markowitsch Jörg , Bjørnåvold Jens
Published: May 2022

Building on the findings of Cedefop’s research project ‘The changing nature and role of VET in Europe’ (2015–18), this article outlines the development and transformation of European VET over the last two decades. Exploring change from epistemological-pedagogical, institutional and socio-economic perspectives, the research not only illustrates the stability and path dependence of national VET systems (and how this sustains overall VET-diversity in Europe), it also demonstrates how the combination of incremental change and major societal and economic shocks shift the orientation of VET. This mapping and analysis of the past is used to outline possible scenarios for the future of vocational education and training in Europe. Three main scenarios - pluralistic, distinctive and special-purpose VET - illustrate the different directions VET can take in the next two decades and the challenges and opportunities involved in this. The final part of the article discusses the potential use of the scenario-approach and how this is taken forward in Cedefop’s follow-up project on the Future of VET (2019–2022).
The characteristics of social problem-solving among Palestinian adolescents
Authors: Aburezeq Khalil , Kasik László
Published: May 2022

Social problem-solving skills are the individual's way for better social adaptation. Therefore, the study aimed to investigate the characteristics of Palestinian adolescents' social problem-solving (Positive orientation, negative orientation, rational style, impulsive style, and avoidance style) in connection to some demographic variables (i.e. gender, age, family composition, father's education, and mother's education). As an instrument, Social Problem-Solving Inventory-Revised (SPSI-R) was applied to 410 Palestinian adolescents whose ages (12, 15, and 18 years old). The results showed that the Palestinian adolescents had the highest level of positive orientation and the least level of negative problem orientation towards solving social-problems. In addition, the finding showed that there were no differences between girls and boys in positive orientation, rational style and impulsive style, while females had a tendency towards negative orientation and avoidance style. There were no differences attributed to age in negative orientation, rational style, impulsive style, and avoidance style. However, it was found that positive orientation was prominent in 18 years old. There was no difference in adolescents' family composition in their dealing with social problems. Also, there was no difference in solving social problems attributed to the father's education. However, there was no difference in negative orientation, positive orientation, rational style, and impulsive style attributed to mother's education. However, there was a relationship between the mother who has elementary school and avoidance style.
Sistem Keamanan Pintu Rumah Berbasis Internet of Things via Pesan Telegram
Authors: Arifin Jaenal , Frenando Jery , Herryawan Herryawan
Published: May 2022

Pada era sekarang ini, banyak didapati kasus keamanan rumah yang semakin kompleks. Hal ini yang mendasari penelitian ini dilakukan. Penelitian ini bertujuan membuat sistem keamanan pintu rumah dengan notifikasi pesan via aplikasi telegram yang diharapkan memberikan rasa aman bagi pemilik rumah dengan. Sistem keamanan pintu rumah ini menggunakan Wemos D1 R1 sebagai mikrokontroler. Sistem ini dirancang dengan menggunakan aplikasi telegram messenger sebagai notifikasi. Penelitian ini menggunakan proximity sensor yang berfungsi mendeteksi setiap gerakan di sekitar pintu. Di atas pintu dipasang kamera yang dapat menangkap gambar atau objek saat ada gerakan. Sistem ini memiliki 2 cara kerja, yaitu pengecekan secara otomatis dan manual. Sistem bekerja secara otomatis pada saat sensor menangkap gerakan dan kamera langsung menggambil gambar, selanjutnya mengirimkan gambar tersebut ke aplikasi telegram. Sedanhgkan sistem bekerja secara manual dengan cara memasukkan perintah lewat BOT telegram untuk membuka pintu rumah. Hasil pengujian nilai rata- rata kinerja alat secara otomatis dari penangkapan gambar atau objek sebesar 16,7 detik, nilai rata-rata waktu kinerja alat secara manual sebesar 9,7 detik. Nilai rata-rata waktu kinerja solenoid doorlock sebesar 7,6 detik. Hasil pengujian kualitas layanan menunjukkan rata-rata delay sebesar 3,244 detik, dan rata-rata throughput sebesar 301.465 byte/s. In today's era, many cases of home security are increasingly complex. This is what underlies this research. This study aims to create a home door security system with message notifications via the telegram application which is expected to provide a sense of security for homeowners. This home door security system uses Wemos D1 R1 as a microcontroller. This system is designed using the telegram messenger application as a notification. This study uses a proximity sensor to detect any movement around the door. Above the door is installed a camera that can capture images or objects when there is movement. This system has 2 ways of working, namely checking automatically and manually. The system works automatically when the sensor captures motion and the camera immediately takes a picture, then sends the image to the telegram application. While the system works manually by entering commands via the telegram BOT to open the door of the house. The results of testing the average value of the tool's performance automatically from capturing images or objects of 16.7 seconds, the average value of manual tool performance takes 9.7 seconds. The average value of the door locked solenoid performance takes 7.6 seconds. The result of testing the quality of data services show an average delay of 3,244 seconds, and an average throughput is 301,465 byte/s.
Economic and Strategic Determinants of The Trans-Pacific Partnership
Authors:   Embassy of the Republic of Poland in Singapore, Czesław Kozłowski Stanisław
Published: May 2022

This article provides an economic and political analysis of the past and current state of the Trans-Pacific Partnership (TPP) project. The TPP talks, which have been ongoing since March 2010 and now involve 12 nations (Australia, Brunei, Canada, Chile, Japan, Malaysia, Mexico, New Zealand, Peru, Singapore, the United States, and Vietnam), are aimed at lowering trade barriers across a much wider range of sectors than classical preferential trade agreements. Namely, it aims at not only removing tariffs on goods and services, but would also cover labor and the environment, intellectual property, government procurement and state- -owned enterprises. The latter are forced by the US as the cornerstone of the Obama Administration’s economic policy in the Asia Pacific. TPP is thus a vital part of a plan known as ‘Asia Pivot’ strategy and represents American attempts to re-engage Asia. If completed, TPP agreement could serve as a template for a future trade pact among 21 members of Asia-Pacific Economic Cooperation regional group.
Flexicurity Towards Responsibility for the Labour Market Changes
Authors:   Poznań University of Life Sciences, Makarewicz-Marcinkiewicz Agnieszka
Published: May 2022

The concept of flexicurity has been a key issue in the discussions and activities of institutions of the European Union in the field of employment and social policy for about two decades. The purpose of this article is to analyze the idea of flexicurity in the context of responsibility for development of the labour market. The responsibility is mostly transferred to the state and employees, while the employers are exempt from accountability for the social costs associated with the fluctuations in the economic cycle. The article contains the analysis of the labour market flexibilisation process and its compensation with the security system, critical approach to flexicurity models and challenges associated with the implementation of this concept.
The Prospects of the Grand Coalition in Germany
Authors: Nassmacher Hiltrud
Published: May 2022

The pressure for reforms is similar in all established democracies, including Germany. This is true for all policies. Lower income caused by economic development and ageing societies is a burden on all budgets. ! is increases the pressure on political actors to speed up the decision-making process. In 2005 the grand coalition of CDU/CSU and SPD was welcomed by the German people. Many commentators assumed that the political deadlock would be overcome by the government of the two major parties. Because the second chamber (Bundesrat) is the major veto-player in the German federal system, the current CDU/CSU majority in the Bundesrat was a high hurdle for the former red-green government (1998 to 2005), as until 2006 about 80 percent of all laws had to pass the second chamber. This led to early elections. People hope that the grand coalition under Chancellor Angela Merkel will overcome this restriction, which the SPD-led government could not evade.
Populism and National Identity
Authors:   University of Wrocław (Poland), Ociepka Beata
Published: May 2022

Populism became a signi! cant factor of political debates in Eastern and Western countries of the EU and a new force in European party systems in the nineties. The frame for the discussion on populism is made by the representative form of democracy and responding to it dual system of media of communication. The popularity of populist parties and movements nowadays reflects the crisis of representative democracy. It is accompanied by the growing role of media in politics, which might be seen as the result of citizens’ dissatisfaction with the existing models of intermediation. The media also play a crucial role in the process of identity creation, at the same moment they illustrate the dificulty of defining identity anew.
Liberalism vs. Solidarity or Freedom vs. Socialism? Conflicting and Misleading Framings of Mediated Messages in the 2005 Polish Presidential Campaign: A Political Communication Perspective
Authors:   University of Warszawa (Poland), Płudowski Tomasz
Published: May 2022

For most of September and October 2005, the Polish news media were busy covering the parliamentary and the presidential elections in that country. Beginning two weeks apart from one another, with the presidential run-off election following two weeks later, these overlapping campaigns became the most important media and political events of the year. Their conjunction was an occurrence expected to happen once in 20 years because of Poland’s five-year presidential term and a four-year parliamentary term. For the first time since 1989, the result was that the President, the upper house of the parliament (Senat) and the lower house (Sejm) of the parliament are now controlled by the same party, Law and Justice (PiS). For the first time since Solidarity swept both elections, the Polish electorate has also made a definite turn to the right, voting for a political party that supports radical change, the symbolic setting up of a Fourth Republic which will be a morally superior country in contrast to the third Republic, the independent Polish state established after the Solidarity revolution when Poland was the first country in the former Soviet Block to end communism. This essay analyzes the 2005 presidential campaign from the point of view of agenda setting theory of how political communication is framed in campaign messages, media use and media coverage.
The Position of Poland on the Background of Sustainable Development Trends in the Baltic Sea Region
Authors:   University of Szczecin (Poland), Korol Janusz
Published: May 2022

The Baltic Sea Region was the first multi-country region in the world to adopt common goals and actions for sustainable development. The instrument for that cooperation is Baltic 21 (formally “An Agenda 21 for the Baltic Sea Region”). There are two de"nitions of sustainable development (SD): technical and nontechnical. Technical definition: “a sound balance among the interactions of the impacts (positive and/or negative), or stresses, on the four major quality systems: People, Economic Development, Environment and Availability of Resources”. The non-technical definition was given as being: “a sound balance among the interactions designed to create a healthy economic growth, preserve environmental quality, make wise use of our resources, and enhance social benefits” [Global Community Assessment Centre].
The U.S. Supreme Court and the Cold War: Fear V. Security. The Times of Vinson Court and Warren Court
Authors:   Jagiellonian University in Kraków, Laidler Pawel
Published: May 2022

The main field of my study concerns the role of the Supreme Court in American legal and political system. My research frequently focuses on the case law, especially on some of the most important cases in the Court’s history, and on their in#uence on the whole of political, economic, and social relations of the country. I personally believe that American federal judges – among whom the most in#uential are the Justices of the Supreme Court – have gained more power than the Framers of the Constitution agreed to give them. Such situation occurred mostly because of the creation of the power of judicial review by the Supreme Court, which allowed the judiciary to determine the contitutionality of acts created by the other branches of government.
The Status of the European Institutions Officials
Authors:   Nicolaus Copernicus University in Toruń (Poland), Hoffmann Tomasz
Published: May 2022

The European Union increasingly inuences the member states, their political institutions, business groups, commercial business sector and the citizens. The institutions, politics and legal regulations of the Communities inuence also countries and human beings from outside the Union. is inuence means that each member state of the European Union has its own representative in the European Institutions such as European Parliament, European Commission, the Court of Justice and the Court of Auditors
The Development of Lithuanian Statehood in Years 1918–1940
Authors:   Nicolaus Copernicus University in Toruń (Poland), Runiewicz–Jasińska Renata , Dudzińska Kinga
Published: May 2022

The Lithuanian historiography is not a novelty in Polish academic literature. The attempts undertaken many times by historians to examine the Lithuanian past are fully justied by the common history of the Polish and Lithuanian lands. It is worth stressing that there are still many controversial questions in this area, which have not been answered in both Lithuanian and Polish academic circles. Taking into account the basic facts from Lithuanian history in the 20th century, when Lithuanians undertook the first actions towards developing a state which would be offcially recognized by the international community, it should not be surprising that it is a subject frequently discussed by the newest studies, which continually refer to the equally rich literature of the earlier period. The researchers ascribe considerable signi!cance to the circumstances, in which the independent Lithuanian state came into being and to its functioning in the interwar period, in years 1918–1940 . What also had a strong influence on this process were the following events in the history of the state, when Lithuania was in the end incorporated into the Soviet Union.
Alfred Korzybski's Thought and the Question of the Search for Truth in Journalist's Work
Authors:   Nicolaus Copernicus University in Toruń (Poland), Wacławczyk Wiesław
Published: May 2022

In 1933, twelve years aer his Manhood and Humanity came out, Alfred Korzybski (1879-1950), a Polish aristocrat who arrived in the United States during World War I, published his most famous book called Science and Sanity. A former Russian intelligence o!cer, earlier trained as a chemical engineer at the Polytechnic Institute in Warsaw, Korzybski had a broad-ranging intellectual background, which he employed to work out his theory of general semantics. It is beyond doubt that the theory under discussion can help journalists depict the reality of the world in its multidimensional complexity – and thus make their performance more professional.
Book review: Michał Kosman, “United Germany and the Process of European Integration (1990–2002)”, Wydawnictwo Adam Marszałek, Toruń 2004, pp. 205
Authors:   Marie Curie-Skłodowska University of Lublin (Poland), Hofman Iwona
Published: May 2022

Michał Kosman’s book is worth attention not just in the context of the ongoing discussions regarding deteriorating Polish-German relations. It deserves to be read for a number of reasons – in order to verify widespread opinions on the role of Germany in European politics in the final decade of the twentieth century. The most important of these reasons are: high competence of the young researcher (affiliated with universities in Bydgoszcz and Poznań), his balanced opinions and comments formulated on the basis of Germanlanguage publications and magazine articles, and thorough factographical presentation.
“Ibsen e o friso da vida!”, O friso da vida e A gênese do friso da vida, de Edvard Munch
Authors: Zwick Ludmila Menezes
Published: May 2022

RESUMO Para a história da arte, os escritos de artistas são referências documentais importantes. Em razão disso, apresenta-se uma tradução anotada de três textos de Edvard Munch (1863-1944) relativos à história da elaboração de suas obras mais conhecidas, bem como de suas respectivas exposições: o manuscrito “Ibsen e o friso da vida!” (não datado) e os textos posteriores, nele baseados, O friso da vida (1918) e A gênese do friso da vida (1928), que serviram de apresentação à exposição O friso da vida. Esta reuniu grande parte das obras de Munch e foi o projeto artístico de sua vida; assim, tais textos dão voz ao artista e possibilitam interpretar e compreender melhor a obra desse expoente da arte. Esses textos também apontam para a possibilidade de que o próprio artista possa servir de referencial teórico ao estudo de suas obras.
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells
Authors: Schepelmann Martin , Ranieri Marianna , Lopez-Fernandez Irene , Webberley Thomas S. , Brennan Sarah C. , Yarova Polina L. , Graca Joao , Hanif Umar-Khetaab , Müller Christian , Manhardt Teresa , Salzmann Martina , Quasnichka Helen , Price Sally A. , Ward Donald T. , Gilbert Thierry , Matchkov Vladimir V. , Fenton Robert A. , Herberger Amanda , Hwong Jenna , Santa Maria Christian , Tu Chia-Ling , Kallay Enikö , Valenti Giovanna , Chang Wenhan , Riccardi Daniela
Published: May 2022

Significance Statement

Vascular calcification is a major complication in CKD–metabolic bone disorder and an independent predictor of cardiovascular morbidity and mortality. In CKD, impaired calcium and phosphate homeostasis are associated with altered expression of the calcium-sensing receptor (CaSR) in the parathyroid glands and the kidney. The CaSR is also present in the vasculature, but its contribution to total body mineral ion homeostasis is unknown. We demonstrated that ablation of CaSR from vascular smooth muscle cells in knockout mice led to profound mineral ion imbalance. These results demonstrate a previously unknown mode of mineral ion regulation besides the parathyroid glands and the kidneys. Alterations in expression and activity of CaSR in vascular smooth muscle cells would be expected to contribute to mineral ion imbalance in CKD.

Background

Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification in vitro. Conversely, vascular calcification can be reduced by calcimimetics, which function as allosteric activators of CaSR.

Methods

To determine the role of the CaSR in vascular calcification, we characterized mice with targeted Casr gene knockout in vascular smooth muscle cells (
SM22α
CaSR
Δflox/Δflox
).

Results

Vascular smooth muscle cells cultured from the knockout (KO) mice calcified more readily than those from control (wild-type) mice in vitro. However, mice did not show ectopic calcifications in vivo but they did display a profound mineral ion imbalance. Specifically, KO mice exhibited hypercalcemia, hypercalciuria, hyperphosphaturia, and osteopenia, with elevated circulating fibroblast growth factor 23 (FGF23), calcitriol (1,25-D3), and parathyroid hormone levels. Renal tubular α-Klotho protein expression was increased in KO mice but vascular α-Klotho protein expression was not. Altered CaSR expression in the kidney or the parathyroid glands could not account for the observed phenotype of the KO mice.

Conclusions

These results suggest that, in addition to CaSR’s established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.
Effects and Risks of Digital Quality of Life in Russian Regions
Authors:   Novosibirsk State Technical University, Litvintseva G.P. , Karelin I.N. ,   Novosibirsk State Technical University
Published: May 2022

Widespread digital transformation significantly changed people’s quality of life. We hypothesise that the digital component of people’s quality of life had a positive but differential impact on economic growth in Russian regions during 2015–2019. Moreover, economic and institutional risks occurring at the current stage of digital transformation could negatively affect economic development. The research pays special attention to the institutional factor, namely, project management quality and its influence on real gross domestic product (GDP) per capita in Russian regions. Methods of economic research were used such as index, rating, expert evaluation methods as well as regression and panel data models (including those with dummy variables). Transformation assessment was based on an integral index proposed by the authors called the Russian regional index of digital component of people’s quality of life (RRIDCPQL). The value of this digital index was increasing during 2015– 2019. The hypotheses of statistically significant influence of the digital quality of life, regional and temporal unobserved factors on real GDP per capita in 2015–2019 were confirmed. However, the study rejected the hypotheses of the positive impact of digitalisation on the unemployment rate and on the decrease in the share of government employees. Positive influence of digitalisation on the divorce rate was revealed while its negative influence on economic criminality and real income per capita of the population was partially confirmed. The importance of project management quality of the program “Digital economy of the Russian Federation” for regional development was demonstrated. The research results presenting new data on the growth of digital economy can be used to adjust the implementation of digital projects in Russian regions.
Palm Tree Plantation as a Panacea for Poverty and Unemployment Reduction in South-Western Nigeria: A Review
Authors:   Prince Sultan University, Amuda Yusuff Jelili
Published: May 2022

Nigeria as a nation is endowed with both human and natural resources. These resources are enough to solve multifarious challenges such as poverty and unemployment. Unfortunately, the issue of poverty and unemployment in the country receives insufficient attention instead of being the government’s foremost priority in the recent time. Little attention is also paid to the exploration of palm tree plantation as a way forward for addressing the challenges of poverty and unemployment in the country. The present paper reviews literature that investigated palm tree plantation as a remedy to endemic or abject poverty and unemployment in the country. The conceptual framework is used to explore the significant impact of palm tree plantation on poverty and unemployment reduction in the country. The methodology of content analysis of relevant literature was applied. The research results indicated that there are potentials to be tapped in palm tree plantation as a solution to the prevalent poverty and unemployment in the South-western part of the country. The findings reiterated that palm tree plantation can make an essential contribution to the development of infrastructure such as roads, schools, and telecommunications among others. The paper revealed that there is a relationship between palm tree plantation and poverty and unemployment reduction in the South-Western Nigeria. However, the study also identifies the effect of palm cultivation, especially its impact on tropical rainforests. It is thereby suggested that palm tree plantation should be included as part of social intervention programmes. In addition, the government should constitute the Nigerian Palm Oil Board (NPOB) and initiate the Nigerian Palm Plantation Development Act (NPPA) in order to expand the agricultural investment in the country. It is further suggested that palm tree plantation should be used for infrastructural development, such as roads, schools, telecommunications etc. Lastly, Land Protect Act (LPA) should be effectively formulated and executed for safeguarding the socio-environment degradation emanating from palm tree plantation.
Identification of Industrial and Innovative Development Models of Regional Economic Systems
Authors:   Belgorod State Technological University named after V. G. Shukhov, Doroshenko Y.A. , Starikova M.S. ,   Belgorod State Technological University named after V. G. Shukhov, Ryapukhina V.N. ,   Belgorod State Technological University named after V. G. Shukhov
Published: May 2022

New industrialisation challenges, turbulent economic environment and opening market niches change the structure of competitiveness factors and determine the innovativeness of industrial development. In the current context, it is necessary to deepen the analysis of industrialisation and innovation performance of regions. Therefore, this study aims to identify industrial and innovative development models present in Russian regions. To this end, we propose a methodology based on assessing the localisation coefficients of both regional industrialisation and innovation performance. Calculation of these indicators resulted in the creation of four models: Model 1 (low industrial development and low innovation performance), Model 2 (low industrial development and high innovation performance), Model 3 (high industrial development and high innovation performance), Model 4 (high industrial development and low innovation performance). The classification of the constituent entities of the Russian Federation according to the industrial and innovative development model shows that more than 40 % of regions use Model 1 and about 12 % of territories use Model 2. Simultaneously, approximately 27 % of regions (including Tula, Lipetsk, Chelyabinsk, Vladimir oblasts, Republic of Bashkortostan) chose Model 3, which most fully meets the new industrialisation challenges. The high stability of this disproportionate structure indicates the absence of positive dynamics and poor balance of industrial and innovation policy measures in most Russian regions in the period 2015–2019. The study results can be used to create an alternative ranking of innovative development of regions. Further research can apply these findings to assess the efficiency of regional industrial and innovation policies.
Institutional Framework for Synthesis of Market and A Priori Approaches to Industrial Policy
Authors:   Ukhta State Technical University, Kayukov V.V. , Shikverdiev A.P. ,   Pitirim Sorokin Syktyvkar State University
Published: May 2022

The spread of anti-globalisation trends against various forms of economic internationalisation requires the adjustment of the system of economic management in general and industrial policy in particular. Using new institutional approaches, the paper examines industrial policy along with the market subsystem and non-market regulated sectors. All these subsystems interact through the intersection of conventions between economic agents. Industrial convention is characterised by continuous production, technology demands compliance, and standards as an information source (as opposed to the market convention that relies on prices). The research shows that the circulation of production means cannot function only based on universal norms of market behaviour, as it happens in the movement of high liquidity consumer goods. Circulation of production means can be determined by long-term agreements, engineering performance specifications and set prices. The paper demonstrates that the inefficient use of market instruments in the innovation sector may lead to state intervention in the circulation of production means. Therefore, by choosing a coordinated, associative management approach, industrial policy can focus on the creation and implementation of relevant strategic documents, as well as on the adjustment of interactions between economic agents and authorities. The presented findings can be used as a methodology for developing regional and national industrial policies.
Din - Felsefe Tartışmaları Bağlamında Osmanlı Tehâfüt Geleneği -Mûsâ Kâzım Efendi Örneği-
Authors: Demirci Osman
Published: May 2022

Bu makalede Gazzâlî’nin İslâm filozoflarını eleştirmek amacıyla yazdığı Tehâfütü’l-felâsife adlı eserinin ismiyle özdeşleşen ve bir din-felsefe tartışmasına dönüşen Tehâfüt geleneği içinde son dönem Osmanlı âlimlerinden Mûsâ Kâzım Efendi’nin yeri incelenecektir. Bu çerçevede din-felsefe tartışmalarının İslâm dünyasındaki seyri kısaca ele alınarak Tehâfüt tartışmalarına zemin hazırlayan gelişmelere değinilecek, Gazzâlî ve İbn Rüşd’ün karşılıklı eleştirilerine yer verilecek ve Mûsâ Kâzım Efendi’nin de dâhil olduğu Osmanlı dönemindeki Tehâfüt yazarlarının bu tartışmada temel bakış açıları irdelenecektir. Din-bilim, din-akıl tartışmalarının yoğunlaştığı Osmanlı’nın son döneminde şeyhülislâmlık yapan Mûsâ Kâzım Efendi, bir kelâmcı olmasına rağmen Tehâfüt geleneğinde eser veren diğer kelâmcılardan radikal bir şekilde ayrılarak İbn Rüşd’ü Gazzâlî’ye karşı savunacak ve bu tartışma üzerinden İslâm’da din-bilim, din-akıl çatışmasının olmadığını göstermeye çalışacaktır. Mûsâ Kâzım Efendi, Tehâfüt geleneğinde İbn Rüşd’ü merkeze alması, İslâm’ın bir din olarak gelişmeye engel olduğunu ileri süren pozitivist düşünür Renan’ın aynı zamanda bir İbn Rüşd uzmanı olduğunu düşündüğümüzde zamanlama açısından da oldukça ilginçtir. İbn Rüşd’e tekrar yoğun bir ilginin başladığı bir dönemde Mûsâ Kâzım Efendi güçlü bir şekilde İbn Rüşd’ün şahsında felsefenin meşruiyetini temellendirmeye çalışacak ve aynı zamanda İbn Rüşd’ün Gazzâlî’ye yönelik oldukça sert eleştirilerinin çoğuna da katılacaktır.
Taxonomía, distribución y conservación de Funastrum (Apocynaceae; Asclepiadoideae) en México
Authors: Chávez Hernández María Guadalupe , Alvarado-Cárdenas Leonardo Osvaldo
Published: May 2022

Antecedentes: Las especies de Funastrum están ampliamente distribuidas en México y 70 % de sus especies se localizan en el territorio nacional. La información sistemática del género se encuentra dispersa o desactualizada, así como el conocimiento de su distribución geográfica y estado de conservación.
Preguntas: ¿Cuántas especies de Funastrum hay en México y cómo se distribuyen? ¿Cuál es el estado de conservación de las especies en el país?
Especies de estudio: Funastrum .
Sitio y años de estudio: México, 2018-2021.
Métodos: Revisión de herbarios nacionales e internacionales, bases de datos (Trópicos, JSTOR, Naturalista, etc.) y búsqueda intensiva de literatura, evaluación de estado de conservación siguiendo los criterios de la IUCN y análisis de riqueza usando el paquete MonographaR en R.
Resultados: Funastrum cuenta con 14 especies en México, siete de las cuales se encuentran en alguna categoría de riesgo. Se proporciona una clave de identificación de especies y descripciones para cada uno de los taxones, así como mapas de distribución y un mapa de riqueza.
Conclusiones: México es reconocido un centro de diversidad para el género, donde 14 de las 20 especies están en el territorio. Para siete taxones se sugiere su inclusión en alguna categoría de riesgo.

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Análisis de factores determinantes de emprendimiento social en jóvenes universitarios
Authors: Caldera González Diana del Consuelo , Velázquez Sagahón Francisco Javier , Zárate Negrete Laura Elena
Published: May 2022

En años recientes, el emprendimiento social se ha posicionado como una alternativa para el desarrollo, la generación de riqueza y el abatimiento de problemas colectivos; así, desde las universidades se ha explorado la manera de incorporar este tema como una competencia transversal en los planes y programas de estudio. En esta investigación se realizó un diagnóstico de factores determinantes de emprendimiento social en jóvenes universitarios en México con lo cual se logró identificar áreas con oportunidad de fortalecimiento desde el perfil emprendedor social de estudiantes y egresados. La metodología fue de tipo cuantitativa, de alcance correlacional y de diseño no experimental. Se elaboró una encuesta de 80 ítems y se validó a través del índice de confiabilidad alfa de Cronbach (.937). Dicha encuesta se aplicó a una muestra incidental de 966 jóvenes inscritos en 64 universidades de México. Los resultados apuntan a la importancia de los factores endógenos, como el control y la autonomía, para la determinación del perfil emprendedor social de jóvenes universitarios. Se determinó también que ni los factores exógenos ni las características sociodemográficas mostraron una correlación significativa con el perfil emprendedor social. En las conclusiones se enfatiza la necesidad de fortalecer las competencias de desarrollo humano y personal (endógenas) desde las universidades para el desarrollo de un perfil emprendedor social.
Competencia digital, burnout y compromiso organizacional en educadores de universidades privadas en el contexto de la COVID-19
Authors: Mendoza García Erica
Published: May 2022

Este artículo tiene como objetivo general establecer la relación que existe entre la competencia digital, el burnout y el compromiso organizacional en educadores de universidades privadas en el contexto de la COVID-19. Para ello, se utilizó un diseño no experimental, transversal y correlacional. El muestreo fue no probabilístico intencional. La muestra estuvo conformada por 274 docentes, entre varones y mujeres de 30 a 65 años, y pertenecientes a universidades privadas. Los instrumentos utilizados fueron el Cuestionario de Competencias Digitales Docentes, el Cuestionario de Burnout del Profesorado Revisado y el Cuestionario de Compromiso Organizacional. Se halló una relación significativa entre las variables, pues existe una relación negativa y significativa entre la competencia digital y el burnout, una relación negativa y significativa entre el burnout y el compromiso organizacional y una relación positiva y significativa entre la competencia digital y el compromiso organizacional de los docentes. Además, se analizan las implicancias de los hallazgos respecto a la relevancia que tienen para el desempeño docente y su repercusión en la formación de los futuros profesionales en el contexto del COVID-19.
Factores que afectan la participación activa de estudiantes universitarios en clases remotas en el contexto de la pandemia COVID-19: El caso de la UNE
Authors: Hermitaño Atencio Bernardo Clímaco , Delgado Arenas Raúl
Published: May 2022

Durante el segundo año de la pandemia COVID-19 y la continuidad de las clases remotas en las universidades públicas, se considera que la participación activa y eficiente de los estudiantes en las actividades académicas es de notable importancia para su normal desarrollo integral. En ese contexto, la presente investigación busca analizar los factores que afectan la participación activa de los estudiantes en la Universidad Nacional de Educación (UNE). Para ello, se recogen datos de una nuestra de 104 estudiantes del Departamento Académico de Electrónica y Telemática, quienes tuvieron ninguna o poca participación activa en las clases en tiempos de pandemia; se excluye a los estudiantes que tuvieron una partición regular o buena. Los resultados muestran que los principales factores son el acceso al uso de las tecnologías de la información, la disponibilidad de tiempo, las actitudes y habilidades de trabajo en la modalidad virtual.
Evaluation of agrobiodiversity and its trophic interactions as an indicator of sustainability in productive systems
Authors: Taraborelli P , Carrasco N , Malaspina M , Domínguez MC , Belaus A , López A , Scavone AS , Barbera A , Zamora MY
Published: May 2022

Agriculture has intervened, modified, and simplified ecosystems to obtain some goods and services. Conventional o industrial agriculture emphasizes the use of external inputs and the homogeneity of the landscape; agroecology promotes biodiversity to maximize biological interactions and their ecosystem services. The objective was to evaluate agrobiodiversity and its trophic interactions as an indicator of sustainability by comparing: industrial productive systems, and agro-ecological and semi-natural sites in the southern Pampas region. Samples were taken of mammals, birds, arthropods, and vegetation; with different indices, the food chains and the state of the system were evaluated. The results show that agricultural intensification simplifies landscape structure with a loss of biodiversity and the absence of functional groups (herbivores and nectarivorous). In agroecological wheat, the highest density of links was found and in agroecological pastures the highest grouping coefficient, this reveals greater cohesion and integration among the components of the system and more mechanisms of self-regulation. The agroecological diversity Index showed no differences between the management, this could be related to the presence of a biological corridor in the conventional field that would be increasing biodiversity. The key to achieving sustainable agroecosystems is to procure biodiverse landscapes with patches and corridors of shrub and herbaceous species.
[RETRACTED] Keto Extreme v1
Authors: Keto EFX Extreme
Published: May 2022

[RETRACTED]

Keto Extreme Fat Burner