bluuebunny/crossref_metadata_2025 huggingface dataset:
Article processing charges of health professions category journals in SCOPUS
Authors: Vučković Mirela , Starčević Klasan Gordana , Baždarić Ksenija
Published: November 2023

Introduction and aim: Scientific journals are a key communication channel for the transmission of scientific information, and the publication of articles is mandatory in scientific advancements. Open access publishing enables greater visibility of scientific outputs but publication in open access is rarely free (Van Norden, 2013; Pourret 2022). The aim of this research is to examine the article processing charges (APCs) of journals in the Health professions category within the SCOPUS database, along with their respective business models (hybrid, OA or diamond OA).Methods: We collected data on journals using Scimago, DOAJ and Sherpa Romeo databases, as well as the homepages of journals and publishers. Using the SCImago Journal & Country Rank data for the year 2022, we filtered journals belonging to the field and category of "Health Professions (miscellaneous)". Data were gathered on the number of journals in Scopus, the type of journal (hybrid, open access, diamond journal) and the cost for publishing (APC) an original scientific article/review article in open access. Information about the type of the journal was collected in Sherpa Romeo/DOAJ databases, information on the APCs was found on the pages of the journal or publisher.Results: A total of 60 journals belonging to the category of Health professions in Scopus were identified, with 28 (47%) of them also in the Web of Science database according to Scimago. Of these 60 journals, 28 are hybrid journals, 32 are in open access (53%), including 10 in open access with an APC, and 22 completely free - diamond journals. The publication cost in all journals is in the range from €0 to €3,385.00, with an average median price of €788 (ranging from €0 to €2,895). The average APC is significantly lower in open access journals than in hybrid journals (median €881, ranging from €92 to €2466, versus €2895, ranging from €2045 to €2977), which is in line with previously published results in the medical field (Siler et al, 2018). Most of the diamond journals are in the 3rd (6 out of 22) and 4th quartiles (9 out of 22) or have only recently (3 out of 22) been included in the Scopus database.Limitations of the study: The study sample is small, and has only 60 journals, while there could be more journals connected with health professions in other Scopus categories. Information about waivers was not collected.Conclusion: Journals of the 1st and 2nd quartile, which are considered an important criterion for advancement in the biomedical field, are mostly hybrid journals and the APCs are very high. Consequently, the conclusion emerges that health professions do not have a large selection of journals for publishing in open access, and therefore it is necessary to educate authors to self-archive their articles.
Downregulation of CRHBP is associated with trophoblast invasion inhibition in recurrent pregnancy loss
Authors: Sun Fengrun , Cui Liyuan , Qian Jinfeng , Du Meirong , Wang Songcun
Published: November 2023

In brief

Corticotropin-releasing hormone binding protein (CRHBP) is fundamental to the stress response and plays an important role in parturition during pregnancy. This study shows that abnormal CRHBP expression could be an early warning sign of recurrent pregnancy loss and that CRHBP knockdown could suppress HTR8/SVneo cell invasion by the PKC signaling pathway via interacting with CRH receptor 2.

Trophoblast invasion is critical for placentation and pregnancy success. Trophoblast dysfunction results in many pregnancy complications, including recurrent pregnancy loss (RPL). Corticotropin-releasing hormone binding protein (CRHBP) is fundamental to the stress response and plays an important role in parturition during pregnancy via binding with CRH. To further characterize its function in early pregnancy, we explored the expression of CRHBP in villi during early pregnancy. Compared with normal pregnant women, we demonstrated that the expression of CRHBP decreased in the trophoblasts and villi in RPL patients and that knockdown of CRHBP expression could suppress HTR8/SVneo cell invasion significantly. Our further exploration indicated that the capacity of CRHBP for regulating trophoblast invasion was associated with the PKC signaling pathway via interacting with CRH receptor 2. These findings might provide a new fundamental mechanism for successful pregnancy and a new diagnostic and therapeutic target for RPL.
Corrupción, pérdida de confianza social y justicia restaurativa
Authors: Gaddi Daniela
Published: November 2023

Resumen: El presente trabajo analiza el potencial de la justicia restaurativa para reparar la pérdida de confianza social como daño social específico causado por la corrupción. Para ello, se delimitan conceptualmente las nociones de corrupción y confianza social, se describe cómo la corrupción deteriora la confianza social y se examinan los factores que permiten o impiden a la justicia restaurativa funcionar como una estrategia efectiva de reparación. Finalmente, se formulan algunas propuestas para el abordaje restaurativo de los delitos de corrupción.
Is it Possible to Define the Boundaries of Hate Speech?
Authors: Župerka Kazimieras
Published: November 2023

During the last few years, a phrase hate speech has become widespread as an expression of a legal concept in the Lithuanian language. In the laws of the Republic of Lithuania, the concept of hate speech has not yet been precisely defined and directly established. The usage of the combination of these two words expands the concept of hate, it loses at least somewhat clearer boundaries. However, based on this concept, intentions are expressed to reinforce the laws of administrative law regarding manifestations of hate speech.

In the article, the concept of the Lithuanian noun neapykanta (‘hate’) is explained by its usage in texts, the relationship between this word and other Lithuanian words with negative connotations has been analysed as well. The examples of unmeasured expansion of the concept of hate speech found in research works have been highlighted. Several more prominent cases of public speaking that had a wider resonance, which were associated with hate speech, are discussed from the point of view of language axiology.

Since negative words with a softer definition are not considered at the same level as hate, then prescribing (to) bully, (to) make fun of, (to) push around, (to) intimidate, (to) tease (concept expressed in corresponding words) to the definition of hate is a conceptual mistake. These emotional and verbal or non-verbal speech concepts can be associated with hate but they can also be described as just emotions “until hate”.

Replacing the compound speech that provokes hate with an abbreviated hate speech leads to confusion: different concepts are conflated, it becomes irrelevant, whether it is inciting hatred or just is associated with it – it still tends to be considered a crime (especially in cases where the case of public linguistic expression is related to the so-called vulnerable, protected groups of persons, for example, Gypsies/Roma, LGBT, migrants). Only the direct encouragement of hatred, the call for confrontation can be evaluated and more or less exactly formulated linguistically, and therefore, legally.
The Territorial Dimension of Russian Aggression Against Ukraine—Polish and European Perspective
Authors:   Institute of Geography and Spatial Organization, Polish Academy of Sciences, Poland, Komornicki T. , Wiśniewski R. ,   Institute of Geography and Spatial Organization, Polish Academy of Sciences, Poland, Szejgiec-Kolenda B. ,   Institute of Geography and Spatial Organization, Polish Academy of Sciences, Poland, Duma P. ,   Institute of Geography and Spatial Organization, Polish Academy of Sciences, Poland, Czapiewski K. ,   Institute of Geography and Spatial Organization, Polish Academy of Sciences, Poland
Published: November 2023

Russian aggression against Ukraine and the associated sanctions from the side of the United States and the European Union resulted in gradual changes in the previous directions of the socio-economic linkages. Besides this global scale, the war in Ukraine has also influenced the linkages and the spatial structures on the regional or local levels. The purpose of the present article is to provide an initial identification of the development of new territorial differentiation in three dimensions: socio-demographic (migrations), economic (first of all the official trade exchange), as well as infrastructural (extension and use of transport networks). The focus here was on the potential consequences that can take place in Europe and in Poland (as a country bordering Ukraine and playing a very special role in both the social relations—the inflow of refugees, and in the economic ones—intermediation in the interactions between the European Union and Ukraine). Identification of spatial differentiation was performed on the basis of analysis of various statistical data, including, in particular, cross-border traffic data, Polish foreign trade at LAU1 level, inflow of refugees (official data of the Polish government), or the secondary data, resulting from project work (in particular, ESPON IRiE). The ultimate scale of the influence of war in Ukraine, neither on the society nor on the economy, cannot be established at this stage of the conflict. The studies performed confirm, however, that the consequences (in each of the dimensions analyzed) are highly territorially diversified. This diversification, though, does not concern only countries or even regions. It has also a local dimension and as such should be adequately perceived by the public authorities of different levels.
Military Geography and GeographicalFactor in the Russian War in Ukraine
Authors:   Embassy of the Republic of Armenia in Ukraine, Kyiv, Sayadyan H. Ya.
Published: November 2023

The article draws attention to the increasing military conflicts and wars at the regional level, as well as the role of geography in their preparation and conduct. Military operations always take place in real time and in real space, therefore, the study of the geographical environment is vital for any socially organized structure that has a military organization (armed forces). Geographical factors (the size of territories, population, relief and landscape features, hydrology and climate, forest cover, and other factors) have long been taken into account when planning and conducting military operations or developing (capturing) new regions. In terms of military geography, geographical knowledge of space, and the necessary scale, provides an understanding of contemporary security issues and promotes the idea that such understanding is critical to understanding and managing significant military issues on a local, regional, and global scale. Attention is drawn to specific methods for the preparation and conduct of military operations—geographic information systems (GIS) in conjunction with aerospace sounding. Without them, modern wars are not produced. The importance of some geographical factors is confirmed by specific examples during the Russian aggression against Ukraine (2014–2023).
Kettős bárdlebeny alkalmazása fej-nyaki bőrtumorok műtéti defektusainak rekonstrukciójára
Authors: Major Tamás , Pribelszki Erzsébet , Rácz Tamás , Nagy Kinga , Nagy Szilveszter
Published: November 2023

Bevezetés: A bőr rosszindulatú daganatai a leggyakoribb humán
neoplasmák, melyeknek 90%-a a fej-nyaki régióban jelentkezik. Elsődleges
terápiájuk a műtéti eltávolítás, melynek során gyakran alakul ki valódi
bőrhiány. Ennek zárása ideális esetben színében, vastagságában és
szőrtüszőtartalmában a laesio kiindulási helyével megegyező helyi lebenyekkel
történik. Célkitűzés: Jelen munkánkban egy random vérellátású
helyi lebeny, a kettős bárdlebeny alkalmazásával kapcsolatos első
tapasztalatainkról számolunk be. Módszer: A 2021. november és
2023. június között a fej-nyaki bőrtumor eltávolítása utáni defektus kettős
bárdlebennyel történő zárásán átesett betegeket prospektív módon követtük.
Vizsgáltuk a primer tumor lokalizációját, méretét, az anesztézia módját, továbbá
a korai és késői szövődmények előfordulását. A műtét után legalább 6 hónapig
követett betegek esetében egy, a műtét utáni statusra vonatkozó elégedettségi
kérdőívet töltettünk ki. Eredmények: A vizsgált időszakban 13
beteget operáltunk a kettős bárdlebeny technikájával, átlagéletkoruk 79,6 év
volt. A leggyakoribb lokalizáció a skalp volt, a reszekátumok átlagos mérete
40,5 × 32,1 mm volt. Valamennyi esetben R0-reszekciót végeztünk. 1 esetben a
defektus teljes zárása nem volt lehetséges. Korai szövődményként 2 betegben
részleges lebenynekrózist, késői következményként 2 betegben mimikai
mozgászavart észleltünk. A betegek számára a legzavaróbb következmény a
hegesedés volt. Megbeszélés: A helyi lebeny kiválasztásakor a
defektus elhelyezkedése, mérete, mélysége, a bőr elaszticitása, a defektus
környezetében mobilizálható bőr mennyisége, a Langer-féle erővonalak és a ráncok
iránya, a szőrzet (hajas fejbőr és szemöldök), valamint az arc esztétikai
egységeinek és alegységeinek határai a meghatározó tényezők. Amennyiben a kettős
bárdlebeny kialakításának alapelveit betartjuk (hossz és szélesség aránya, a
lebeny nyelének szélessége a defektus méretéhez képest), elfogadható
szövődményrátával rendelkező, megbízható módszer áll rendelkezésünkre.
Következtetés: A kettős bárdlebeny mint random vérellátású
helyi lebeny különösen alkalmas a hajas fejbőr és a homlok területén
elhelyezkedő 2–5 cm-es bőrdefektusok zárására. Orv Hetil. 2023; 164(44):
1755–1763.
The Inequality of Zakat Distribution to the Indonesia’s Impoverished Muslim Urban
Authors: Darwis Muh , Pabbajah Mustaqim , Harun Dato' Sudin , Adliyah Nurul , Fitriani Fitriani
Published: November 2023

Zakat, which is supposed to be for the alleviation of poverty, has actually been a source of problems because of the fact that the distribution has not been in line with its objectives. This current study addresses the inequality in the distribution of zakat to impoverished urban. The distribution of zakat is one of the substantial instruments for the Islamic financial ecosystem to alleviate poverty. The distribution of zakat aims to cater to impoverished communities’ needs and provide financial protection. This study relays on a descriptive qualitative research design where data were obtained through interviews and literature study. The data is used to analyse the concept of inequality in relation to poverty as a result of the unequal distribution of zakat. The results of this study indicate that the distribution of zakat is personally and unequally distributed. The unequal distribution of zakat impacts the welfare of people experiencing poverty due to inequality in selecting zakat recipients. Not merely that, zakat, which is relatively small and temporary, cannot support the productive ability of people with low incomes to achieve prosperity. Therefore, it is necessary to assert the prioritized distribution of zakat.
Overcoming Theological Dilemmas: Fostering Religious Moderation through the Resolution of Faith and Rationality
Authors: Marjani Gustiana Isya
Published: November 2023

This study aims to explore pertinent philosophical approaches in order to analyze the primary dilemma associated with theological beliefs, which impede the efficacy of religious moderation within the Indonesian context. Consequently, the study endeavors to fortify the framework of religious moderation policies. By anchoring arguments and research within this philosophical paradigm, the author endeavors to establish a robust theoretical underpinning that substantiates the integration of faith and reason in the realm of religious moderation. The chosen methodology for this research comprises a comprehensive literature review, entailing the systematic gathering and analysis of diverse primary and secondary sources. Primary sources encompass relevant scholarly writings that directly address the subject of religious moderation, while secondary sources encompass a compendium of academic works, including books, journals, articles, and papers that specifically delve into the intricacies of this subject matter. The findings of this study demonstrate that the practice of religious moderation is frequently impeded by the exclusivity inherent in theological truths, which undermines the rationality of human actions. Therefore, a resolution between faith and reason is imperative to surmount this quandary, particularly through the facilitation and engagement in interfaith dialogues, the promotion of inclusive theological education, the cultivation of critical and rational thinking, the accentuation of universal moral values and religious virtues, the deepening of hermeneutics and moderation in interpretations, the distancing from identity politics, the spotlighting of spiritual experiences in religious praxis, and the emphasis on the fundamental right to freedom of religion.
Optimization of resistance spot welding with surface roughness dissimilar mild steel with stainless steel
Authors: Ariyanto Ariyanto , Sukardin Muhammad Setiawan , Renreng Ilyas , Arsyad Hairul , Syahid Muhammad , Alwi Muhammad
Published: November 2023

Resistance spot welding plays a critical role in the manufacture dissimilar material industry. However, there are differences in mechanical properties between mild steel and satinless steel so as to reduce the quality of welded joints. In order for differences in mechanical properties to be corrected, surface roughness was treated. The aim of this study was to optimize the welding parameters of DRSW with surface roughness by analysis using the Taguchi and Anova Methods. In this study discusses about investigates the Resistance spot welding parameters on weld geometry, mechanical properties, and SEM EDS on dissimilar materials of mild steel and stainless steel. The material thickness of the mild steel and stainless steel are 1 mm, respectively. The process parameters of the resistance spot welding joint used, example; surface roughness, current, welding time, and electrode force. Quality welding joint test results include weld geometry, mechanical properties, and SEM EDS. Weld geometry testing to determine the weld nugget profile. The mechanical properties test was shear tensile test, while the SEM EDS included macrostruture and microstructure observations. The results showed the highest nugget diameter 6.65 mm highest shear tensile strength 7.66 kN. The most influential parameter is current by 75.08 %, then surface roughness by 12.35 %. The highest tensile strength has fewer defects. Surface roughness treatment before welding is very good to make welding quality joints between mild steel and quality stainless steel increase. Surface roughness treatment was very good to be included when making welding procedures for welding engineers for welding processes resistance spot welding dissimilar mild steel with stainless steel.
Identifying the features of surface roughness and H2 bubble production on the super-hydrophobic properties of Al2O3 and Mg membranes
Authors: Subagyo Rachmat , Wardana I. N. G. , Widodo Agung Sugeng , Siswanto Eko , Nugraha Andy , Fadilah M. Munawar , Agusnaedi Agusnaedi , Ramadhani Ahmad Fadhila
Published: November 2023

This research investigates Alumina (Al2O3) and Magnesium nano membrane layers using hybrid technology. Hybrid is a concept of combining two or more materials/elements to achieve something better. Hybrid technology was developed because of the possibility of combining materials/elements which, if used simultaneously, has more advantages than if used independently. The problem to be solved is to find the best composition of Alumina and Magnesium hybrid membranes. Superhydrophobic properties of the membrane are achieved at a percentage of Mg: 50 %, Al2O3:50 %. At a composition below 50 % Mg, the small surface roughness has a low surface tension, while the H2 production reaction by Mg is also low, so the surface tension carrying capacity of the gas and the roughness of the droplets is not strong, which causes the hydrophobicity to be low. In compositions above 50 % Mg, H2 production by high Mg makes bubbles cover the roughness peaks so that the surface tension is lower and changes the superhydrophobic to hydrophobic properties. At a high Mg percentage, H2 production is very large, while surface roughness decreases due to minimal Al2O3. As a result, the roughness grooves are unable to accommodate H2 gas bubbles, the bubbles completely cover the roughness peaks which are the source of surface tension so that the hydrophobic properties become hydrophilic. The results of this best hybrid composition can be used as a guide in making superhydrophobic membranes on Alumina (Al2O3) and Magnesium alloys. This membrane application is used as a filtration membrane in the water purification process. Superhydrophobic membranes are widely applied in membrane distillation, membrane gas absorption and pervaporation
Ensuring the stability of machining when using end mills
Authors: Petrakov Yuri , Ohrimenko Olexander , Sikailo Maxim
Published: November 2023

This paper reports a new approach to ensuring the stability of the end milling process, due to vibration-free cutting modes, which are determined from the stability lobes diagram of the dynamic machining system. An application program for automatic calculation of the stability lobes diagram in the coordinates «mill spindle speed – feed» has been developed, which is a tool for the technologist-programmer when designing control program for numerically controlled machines. The mathematical model underlying the application program represents a dynamic machining system as a single-mass system with two degrees of freedom, covered by negative feedback in the direction of two coordinates. The trailing machining is represented as positive feedback loops with a delay function in each. The mathematical model is given in the form of state variables, which allows applying numerical modeling methods to determine both transient and frequency responses. The software developed includes a separate module for automatic design of the stability lobes diagram whose algorithm uses the features of the location of the Nyquist diagram on the complex plane. Since the functioning of the developed program requires a priori information about the dynamic parameters of the machining system, a procedure for their experimental identification is presented. The stiffness of the machining system in two coordinates was determined with the help of a dynamometer, and the frequency responses were determined by the impulse response function, which was obtained with an impact hammer. The research results were confirmed experimentally both by computer simulation and milling on a machine tool and could be recommended for determining the cutting mode at end milling
Construction of a simulated dynamic model of data packet routing on a telecommunication network fragment
Authors: Turovsky Oleksandr , Zakharzhevskyi Andrii , Makarenko Anatoliy , Dakova Larysa
Published: November 2023

The object of the current research is the process of routing data packets in a telecommunications network. It was established that the state and parameters of data transmission channels and routers could have a negative impact and need to be taken into account in the process of modeling the routing of data packets in telecommunication networks.
A model of simulated dynamic modeling of data packet routing in telecommunication networks has been devised and proposed. The suggested model makes it possible to establish quantitative values of the delay time of processing data packets during their routing along a separate segment of the telecommunications network, taking into account the state and parameters of the data transmission channel and routers.
It has been established that the achievement of the minimum delay time of data packets during routing is achieved by choosing the path of their transmission under the condition of minimum transmission time by communication lines and the capabilities of routers in terms of their accumulation and service speed. At the same time, the reduction of packet transmission delay time relative to the average for the time network segment can reach from 21 to 38 percent. It is shown that the main factor affecting the value of the delay time is the speed of data processing along the selected path of packet transmission. The number of routing nodes in a separate data transmission path can affect the delay time only if the parameters of the routers are equal compared to others that are included in alternative routes.
The model of simulated dynamic modeling of data packet routing reported in this work, unlike the existing ones, takes into account the state and parameters of data transmission channels and routers. It can be used in practical improvement of existing and development of new multi-service telecommunication communication networks
Determining the technological parameters of electron-beam welding of high-strength titanium alloys
Authors: Fedosov Oleksiі , Karpovych Olena
Published: November 2023

It is usually quite difficult to carry out deep penetration of thick-walled products from titanium alloys using conventional welding technologies. In this study, it was proposed to use electron beam welding under high vacuum conditions for the realization of 40 mm thick melting of VT23, VT3-1 alloys.
This paper considers the possibility of obtaining high-quality welded joints from high-strength titanium alloys having (a+β) two-phase structures. For the implementation of research works, samples were made from selected materials, samples were welded according to the specified modes, metallographic analysis was performed, and the level of mechanical properties was determined. The research results were verified under laboratory conditions.
The technological features of the processes of electron-beam welding of products with a thickness of 40 mm were considered; the parameters affecting the weldability of titanium alloys and their structure were determined. The welded samples were checked by X-ray non-destructive testing, the microstructure of the welds was studied, and the physical and mechanical properties of the welded joints were checked. It was established that a feature of titanium alloys VT3-1, VT23 is the need for heat treatment after welding under the base metal regimes to improve the characteristics of the welded joint. The resulting strength limit of the alloys after heat treatment reached values of 1250 MPa and more, while the impact toughness was at the level of 48–50 J·cm-2.
Modeling the welding process has made it possible to ensure the reproducibility of the characteristics of the welded joint at a level close to that of the base metal, to increase the quality indicators of welded joints, and to reduce the time required to test the technology. The studies of simulator samples showed compliance of the quality of welded joints with the predefined parameters.
Construction of mathematical model of particle movement by an inclined screw rotating in a fixed casing
Authors: Volina Tetiana , Pylypaka Serhii , Kalenyk Mykhailo , Dieniezhnikov Serhii , Nesvidomin Viktor , Hryshchenko Iryna , Lytvynenko Yana , Borodai Artem , Borodai Dmytro , Borodai Yana
Published: November 2023

Screw conveyors are used to move bulk materials vertically upwards, horizontally, and at an angle to the horizon. The processes that take place when particles are moved by a screw conveyor in vertical and horizontal directions have been studied. There is a significant difference between them: for transportation in the vertical direction, the necessary conditions must be ensured (sufficient angular speed of rotation of the screw), and for horizontal transportation, the movement of the particle occurs at any angular speed of rotation of the screw. Therefore, when changing the inclination of the axis of the screw, there comes a moment when transportation becomes possible, while it was impossible in the vertical direction.
This paper considers the movement of a particle under the condition that it simultaneously contacts two surfaces: the moving surface of the screw and the stationary surface of the cylindrical casing in which the screw rotates. Their common line along which the particle slides is a helical line – the periphery of the screw. The particle slides along the helical line of the rotating screw, i.e., it is in relative motion with respect to it. At the same time, it slides along the surface of the casing, relative to which it is in absolute motion. The trajectory of the particle's absolute motion is its sliding track on the casing surface.
When constructing differential equations of the relative motion of particles, the forces applied to the particle were taken into account. The initial position was taken to be the vertical direction of the screw to transport the particle upwards. If an auger in a cylindrical casing is tilted from the vertical direction to a certain angle, then all applied forces (except the force of weight) will also tilt to this angle. On the basis of this, generalized differential equations of the relative motion of a particle during its transportation by an inclined screw were built. They made it possible to derive a generalized mathematical model of the movement of a particle by an inclined screw that rotates inside a fixed casing
Improvement of the vacuum evaporator for the production of paste-like semi-finished products with a high degree of readiness
Authors: Minenko Sofiia , Cherevko Oleksander , Skrynnik Viktoriia , Tesliuk Hennadii , Bondar Mariana , Skoromna Oksana , Liulchak Svitlana , Postadzhiev Alexander
Published: November 2023

The object of this study is the process of cooking blended pureed mass based on apple, Jerusalem artichoke, cranberry, and hawthorn in an improved vacuum evaporation apparatus with a unified stirrer for the production of paste-like semi-finished products with a high degree of readiness. Conventional devices for cooking are associated with intermediate heat carriers, significant energy and metal consumption, the difficulty of stabilizing the temperature field under the conditions of a significant duration of the process, which prevents ensuring mobility, resource efficiency, and reducing the quality of resulting products. This led to the improvement of the vacuum evaporator by replacing the steam jacket with a film-like resistive electric heater of the radiating type, with the simultaneous use of a unified stirrer to increase the useful heat exchange surface by 0.6 m2. This was achieved by heating the internal space of the stirrer with the heater mentioned above, thereby forming the total area of heat exchange up to 2.8 m2, which is 28 % more than the area of the prototype (2.2 m)2. The rheological parameters of the resulting fruit and vegetable paste at a boiling temperature of 50...55 °C at a shear rate of 0.8...2.0 s-1 were determined, while the effective viscosity was in the range of 5.0...18.0 Pa·s. At the same time, the character of boiling kinetics in the improved vacuum-evaporating apparatus was 30 % lower than the indicator for the basic design MZ-2S-241a.
The improved vacuum-evaporator with a unified stirrer is characterized by reduced specific heat consumption for heating the loaded pureed semi-finished product by 13.8 %. By increasing the heating surface by 28 % and reducing the duration of the temperature load on the product according to experimental data in the device by 29.6 %
Synthesis of an electromechanical system of body tilt and recuperation of vibration energy for a high-speed electric train
Authors: Ozulu Anton , Liubarskyi Borys , Iakunin Dmytro , Dubinina Oksana
Published: November 2023

This paper considers issues related to the undercarriage system of a high-speed electric train with body inclination and a vibration recovery system. The main suspension systems of the electric train body, which are currently used, were investigated. The existing shock absorption systems and alternative approaches and solutions for increasing the speed characteristics of electric rolling stock have been highlighted. A basic problem of these suspension systems was put forward, which is the lack of the possibility of recovery of oscillations, as well as the complexity of systems for tilting the body. The main dimensional and power parameters of the proposed promising shock absorber are presented. The characteristics of basic parameters of the electromechanical shock absorber were compared with those of a pneumatic spring shock absorber. A simulation model of a high-speed electric train with an electromechanical shock absorber was built in the MATLAB Simulink environment. The main units of the simulation model were defined and described, owing to which it is possible to simulate the inclination of the body to a given angle and the simulation of vibration energy recovery.
Based on the results of simulating the operation of an electromechanical shock absorber as part of the undercarriage of the electric locomotive, it was determined that the synthesis of this system makes it possible to tilt the body by 5 degrees in 2 seconds. It is also stated that the proposed system makes it possible to reduce the vibrations of the electric train body by 2 times, and to recover 84 W/h of vibration energy. The body tilt results are predetermined by the speed of the mechanism due to the absence of a compressor set used in the pneumatic system.
The scope of application of the vibration damper also includes the automotive field, subject to additional research into the form, amplitude of road surface vibrations and changes in overall parameters in accordance with the requirements
A structural model for building a system for the development of methodological competence and methods for evaluating its effectiveness
Authors: Biloshchytskyi Andrii , Omirbayev Serik , Mukhatayev Aidos , Kuchanskyi Oleksandr , Biloshchytska Svitlana , Andrashko Yurii , Toxanov Sapar , Faizullin Adil
Published: November 2023

The paper develops a structural model for building a system for developing methodological competence. The structural model is built based on a service-oriented approach to developing large software complexes and includes six subsystems. Each subsystem is implemented as a separate microservice, which allows system scaling. The paper describes a technique that allows you to build a teacher’s competency map and evaluate its eight components: cognitive, didactic, project, informational, communication, reflective, monitoring, and personal-motivational. A four-level scale is proposed for assessing the level of competencies. A methodology for evaluating the effectiveness of the methodical competence development system based on the hierarchical expert method has been developed. The system was verified and implemented. According to the results of the system implementation, the intensification of the educational process and the improvement of the training quality of students were recorded. Students’ success in studying subjects has increased significantly. Namely, the number of bad students has decreased by 15 %, the number of «excellent» students has increased by 10 %, and the number of «good» students has increased by 18 %.
The paper touches upon creating information technologies adequate for improving the higher education system. The goal is the targeted development and implementation of information technologies in educational institutions and the creation and operation of integrated, flexible software to support a mixed system for organizing the educational process, as well as increasing the efficiency of implementing a mixed system for organizing the educational process.
Assessment of the possibility of using the fruits of the oriental persimo (Diospyros kaki L.) as a source of filter membranes based on the tensor approach
Authors: Khalilov Mushfiq , Ismayilova Melahet , Gasimova Afet , Kazimova İlhama , Maharramova Sevinj , Omarova Elza
Published: November 2023

Like all raw materials of plant origin, persimmon fruits are considered a material rich in carbohydrates. This subtropical plant grows almost throughout the entire territory of the Republic of Azerbaijan. Despite the widespread distribution of this plant in the republic, very few types of products are produced from it. The main reason why persimmon fruits are not used effectively from a production point of view is that they have astringent properties. Since fruit carbohydrates play an important role in eliminating the tart taste of persimmons, the study of the carbohydrate complex was considered as a basic condition.
After fractionation of carbohydrates with a water-alcohol mixture, certain stresses arise in the filter residue, which consists of cellulose-lignin. These stresses are analyzed using tensors. It has been established that the size of the filter pores is about 0.005÷0.05 microns, and the volume of these pores is 0.062÷0.195 cm3/g. The clearance coefficient averaged 19.97 %.
It is known that the outer layer of a plant cell consists of cellulose and other structural compounds. These substances determine the porosity of the material. The mass fraction of the final product of the fractional residue, more precisely cellulose, averaged 0.63 %.
The use of the resulting filter membrane in the clarification of fruit juices has shown its usefulness in industry. It has been established that the selectivity of these membranes for various amino acids is 5÷18 %, and for minerals 1÷30 %. The lipid resistance of the membranes was high. It should be noted that cellulose has the ability to restore its structure and at the last stage acts only as a filter membrane. This explains the usefulness of the cellulose-lignin mixture as a membrane material
Synthesis, docking study and antimicrobial activity evaluation of pyridyl amides of thieno[2,3-d]pyrimidine-4-carboxylic acid
Authors: Vlasov Sergiy , Severina Hanna , Vlasova Olena , Borysov Oleksandr , Shynkarenko Pavlo , Golovchenko Olga , Konechnyi Yulian , Georgiyants Victoriya
Published: November 2023

The aim. The combination in one molecule of pharmacophore fragments of thieno[2,3-d]pyrimidine-4-carboxylic acids with the fragments of 2- or 4-aminopyrimidine by peptide coupling promoted acylation in order to develop the new drug-like molecules with antimicrobial activity.
Materials and methods. The molecular docking studies were performed with the AutoDock Vina та AutoDockTools 1.5.6 programs; TrmD Pseudomonas aeruginosa PDB ID – 5ZHN was used as the protein target. Synthetic methods of peptide coupling were used. 1H and 13C NMR spectra were recorded with a Varian-400 spectrometer at 400 MHz and Bruker Avance DRX 500 device at 500 MHz and 125 MHz in DMSO-d6 as a solvent, using TMS as the internal standard. LC-MS analysis of the compounds was carried out with Agilent 1100 HPLC з with atmospheric pressure chemical ionization (APCI). The studied derivates were tested in vitro for their antibacterial and anti-fungal activities using agar diffusion and serial dilutions resazurin-based microdilution assays (RBMA).
Results and discussion. By the combination of the pharmacophore fragments of thieno[2,3-d]pyrimidine-4-carboxylic acids with the fragments of 2- of 4-aminopyrimidine, the combinatorial library of amides was constructed. For this library of compounds, the potential of antimicrobial activity was revealed using docking studies to the TrmD enzyme isolated from P. aeruginosa. The peptide coupling promoted by 1,1'-carbonyldiimidazole was found to be effective for the synthesis of pyridyl amides of thieno[2,3-d]pyrimidine-4-carboxylic acids, and it allowed to combine these pharmacophores in one molecule. The results of antimicrobial activity study revealed the broad spectrum of antimicrobial activity for N-(pyridin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-carboxamide (2g), while 5,6-dimethyl-N-(6-methylpyridin-2-yl)thieno[2,3-d]pyrimidine-4-carboxamide (2c) showed the best MIC value against the reference strain of Pseudomonas aeruginosa ATCC 10145. N-(6-Methylpyridin-2-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-carboxamide (2h) was also found to be active against Pseudomonas aeruginosa.
Conclusions. An effective method for the synthesis of pyridyl amides of thieno[2,3-d]pyrimidine-4-carboxylic acid has been developed. The amides molecular docking method showed their ability to inhibit TrmD enzyme isolated from P. aeruginosa; the further in vitro studies of the compounds showed the rationality of the further studies of the derivatives with 2-amino-6-methylpyridine in amide substituent because this fragment favoured the selectivity against Pseudomonas aeruginosa
The study of the stability of silver proteinate solutions prepared in pharmacies
Authors: Cherniakova Valeriia , Bevz Nataliia , Strilets Oksana , Harna Nataliia , Bevz Olena , Yevtifieieva Olga
Published: November 2023

Today, medicines made in pharmacies are increasingly attracting consumers' attention and are in growing demand in Ukraine. Pharmacy production faces a number of problems, including the study of the stability of extemporaneous dosage forms and the determination of an optimal shelf life. 1 % and 2 % water silver proteinate solutions used in ophthalmology, otolaryngology and nephrology are produced in Ukrainian pharmacies both extemporaneously and as a reserve.
The aim. The aim of the work is to develop methods for quality support and study the chemical stability of 1 % and 2 % water solutions of silver proteinate, and to study the microbiological purity to extend the storage time of nasal drops.
Materials and methods. A study of the chemical stability of 1 % and 2 % water silver proteinate solutions of pharmaceutical production is carried out using chemical identification reactions (to silver and protein), quantitative determination by thiocyanatometric titrimetric method and determination of microbiological purity.
Results. The validation characteristics of the method for the quantitative thiocyanatometric determination of silver proteinate were studied (the correlation coefficient r = 0.9995 and 0.9996; the systematic error – 0.26 % and 0.03 %, the relative confidence interval – 0.88 % and 0.74 % for 1 % and 2 % solutions, respectively), as well as its suitability for this purpose was proven. “Silver proteinate solution, 1.0 %” and “Silver proteinate solution, 2.0 %” prepared in the pharmacy were studied for 150 days by the “Microbiological purity” indicator and were biologically stable.
Conclusions. The chemical identification reactions and methods for the quantitative determination of silver proteinate in an extemporaneous dosage form used to study the chemical stability of the drug have been proposed. The study results of the chemical stability and microbiological purity allow us to recommend pharmacies to extend the shelf life of nasal drops containing silver proteinate as an active pharmaceutical ingredient for 150 days
Research by choice of excipients ingredients of the gel for the therapy of radiation lesions of the skin based on rheological studies
Authors: Burban Ksenija , Kukhtenko Halyna , Kriukova Anna , Yakovenko Volodymyr , Matsiuk Ksenia , Slipchenko Halyna , Vyshnevska Liliia
Published: November 2023

The aim of this work is to conduct a research analysis of changes in the structural and mechanical properties of the gel from the addition of active substances and surfactants.
Materials and methods. In the presented work, model samples of the gel with active substances were studied: freshly obtained stonecrop juice, sea buckthorn oil, rosehip oil, St. John's wort oil and quercetin. As substances for the manufacture of bases hydrocolloids of cellulose derivatives were used: sodium carboxymethylcellulose (NaCMC) and hydroxyethylcellulose (HEC) with a surfactant Lanette SX.
A study of the rheological properties of the samples was performed using a rheoviscometer Rheolab QC (Anton Paar, Austria) using a system of coaxial cylinders C-CC27 / SS. The Rheolab QC rheometer is equipped with RheoPlus software, which allows you to set the necessary experimental conditions (shear rate gradient range, number of measuring points and measurement time of one point).
Results. The rheological properties of model samples of NaCMC and HEC gels, depending on the used concentration, were studied. With increasing concentrations of both NaCMC and HEC thixotropy of dispersed systems decreases. The change of structural and mechanical parameters of hydrogels from the addition of active ingredients and surfactant is analyzed, and established that adding them into the hydrogels increases the structural and mechanical parameters of model samples.
A study of gels with a constant concentration of sodium carboxymethylcellulose and hydroxyethylcellulose and different content of surfactant Lanette SX established that as the surfactant concentration increases, the area of the hysteresis loop and the resistance of the dispersed system to the applied mechanical fracture increase.
Conclusions. According to the results of the obtained structural and mechanical parameters and rheograms of the studied model samples of gels, it is rational to use in further studies of sodium carboxymethyl-cellulose (1.5 %) and hydroxyethylcellulose (1.25 %) stabilized Lannete SX in concentrations of 4-5 % and 3-5 % respectively
Application of the direct encapsulation method in the technology of medicine with dry rauwolphia extract (Rauvolfia serpentina Benth.)
Authors: Zlahoda Viktoriia , Bobrytska Larisa , Nazarova Olena , Tarasenko Viktoriia , Shpychak Oleh , Nazarkina Viktoriia , Hrytsenko Vita
Published: November 2023

The aim: development of the composition and technology of a medicinal drug in the form of capsules with a dry extract of Rauwolfia for the treatment of hypertension.
Materials and methods. Experimental samples of masses for encapsulation contained 2.0 mg of dry Rauwolfia extract and various excipients used in the technology of solid dosage forms. The study of pharmaco-technological characteristics was carried out on the devices of the company "Pharma Test" (Germany). The time of decay was determined on the device of the company "Erweka" (Germany). A comparative analysis of the cost calculation of the production of tablets and capsules with dry rauwolfia extract was carried out by the "cost plus" method.
Results. The use of PROSOLV® SMCC HD 90 improved the flowability, homogeneity and homogeneity of the mass with Rauwolfia dry extract powder, considering the low dosage of the substance of 2 mg. It has been experimentally proven that PROSOLV® SMCC HD 90 shortens the disintegration time as a disintegrant, because due to silicate moisture easily penetrates into the MCCC, hydrophilic bridges are formed, wettability increases and mass swelling occurs. The multifunctionality of PROSOLV® SMCC HD 90 three-in-one excipient, which has the properties of a filler, a disintegrant and a glidant, makes it easy to apply direct encapsulation technology, replace and reduce the number of excipients and thus increase production efficiency.
Conclusions. When developing the composition of capsules with dry rauwolfia extract, the effect of various excipients on the pharmaco-technological properties of encapsulating masses and ready-made capsules was investigated. The combined excipient, namely PROSOLV® SMCC HD 90, having the properties of a filler, a disintegrant and a lubricant, in direct encapsulation technology is more effective in influencing the fluidity of the mass and disintegration of the capsules. The introduction of the direct encapsulation method will allow to expand the range of new medicines and improve existing technologies, in particular in the form of tablets, which are widely produced in industrial production. it is possible to attach specifically to Rauwolfia
El ser humano como sujeto social
Authors: Gaviria Rojas León Darío , Nasif Arciniegas Jalal Othman
Published: November 2023

Como sujeto social el ser humano interactúa con otras realidades, circunstancias, entornos y esto hace posible que sea considerado socialmente responsable en el cuidado de sí mismo, de los recursos naturales, de crear nexos interculturales y renunciar al individualismo absoluto en el que predomina el egoísmo, el narcisismo, la indiferencia ante las situaciones externas, a tal punto de fragmentar las redes y rutas de trabajo colaborativo e interacción colectiva.