bluuebunny/crossref_metadata_2025 huggingface dataset:
TRAINING OF A FUTURE TEACHER OF PRESCHOOL ESTABLISHMENTS FOR THE REALIZATION OF AN INTEGRATED APPROACH TO PRESCHOOLERS’ EDUCATIONAL PROCESS
Authors:   Senior Lecturer of Methods of Preschool and Primary Education Department, Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, KOTELIANETS Yulia
Published: January 2021

The purpose of the article is to reveal the importance of preparation of future preschool teachers for implementation of an integrated approach into children's education and to identify key concepts of integration in which the future pre-school teacher should be competent. Integration as a principle of development of pedagogical theory and practice of preschool education is a leading idea that reflects the harmonious integration among educational lines and as a result creation of a single inseparable educational process and guarantees its implementation the achievement of higher results in the development and upbringing of children of preschool age. Integration as a process involves the direct establishment of harmonious links among the defined systems of integration and the creation of a new holistic education system for preschool children in accordance with the defined result. As a process, integration involves the integration of objects (educational lines, different types of children's activities, forms and methods) and designing a way to obtain the expected result. As a result of the educational activities of the preschool institution, integration does not involve the amount of knowledge, skills and abilities, but the acquired integrative qualities of the child, such as curiosity, activity, independence, responsibility, upbringing, etc. Integration as a result is considered by researchers through the form of its organization in the educational process, namely the possible forms of preschoolers’ integrated learning (projects, holidays, travelling, excursions, business and role-playing games), which immerse the preschooler into learning. In the process of integrated studying with the help of different interdisciplinary links, children’ comprehensive and objective vision of the problems of reality and diverse approaches to their solution are formed. A competent preschool teacher should be ready to implement an integrated approach in the process of their practical activities. This will allow to implement the tasks defined by the normative documents in the field of preschool education for teaching children and the formation of their life competencies.
CRITERIA FOR LITERARY DEVELOPMENT OF STUDENTS
Authors:   Ph.D in Philology, Associate Professor of World languages Department, International Kazakh-Turkish University named after H.A. Yasavi, The Republic of Kazakhstan, BEISEMBAYEVA Saltanat , KARPYKBAEVA Akmaral ,   Ph. D., secondary school teacher, The Republic of Kazakhstan
Published: January 2021

Introduction. Qualitative changes in the perception of fiction by schoolchildren of different ages pose the task of methodologists to define the concept of "literary development" and its criteria, which to a large extent should determine the direction and methods of studying artistic works. The methods. Definition of the concept of "literary development" and its criteria, which to a large extent should determine the direction and methods of studying artistic works. Results. Need form validation that would test both knowledge and skills, and yet would contain clear criteria for assessing knowledge and skills of students with different level of training, would be consistent with the concept of school literary education and educational standards in the literature, including "Requirements to level of preparation of students". The main school should form an understanding of the specific laws of literature and the nature of its impact on the reader. In grades 5–9, there is a "systematic accumulation of information and ideas related to the generic, genre and stylistic specifics of literature". A graduate of a basic school should become a reader capable of "artistic perception, their own reflections, experiences, associations". The level of literary development of schoolchildren is closely related to their philological abilities, age and individual characteristics, and the effectiveness of educational activities. The most important quality of the reader – the need to Express a feeling, idea, thought in the word, "germination" words in visual, auditory, and other associations, emotional sensitivity to the word, intonation and style of speech, a holistic attitude to the literary work, a General look at its architecture, the conceptual perception of the composition. Originality. The content of literary education of high school students in accordance with these criteria allows us to speak about their readiness for independent re- search work in literature lessons. Conclusion. The level of literary development of schoolchildren is closely related to their philological abili- ties, age and individual characteristics, and the effectiveness of educational activities. The most important quality of the reader – the need to Express a feeling, idea, thought in the word, "germination" words in visual, auditory, and other associations, emotional sensitivity to the word, intonation and style of speech, a holistic attitude to the literary work, a General look at its architecture, the con- ceptual perception of the composition.
Bilateral squamosal synostosis: unusual presentation of chromosome 1p12–1p13.3 deletion. Illustrative case
Authors: Chaisrisawadisuk Sarut , Vatanavicharn Nithiwat , Praphanphoj Verayuth , Anderson Peter J. , Moore Mark H.
Published: January 2021

BACKGROUND

Squamosal sutures are minor sutures of the human skull. Early isolated fusion of the sutures (squamosal synostosis) is rarely found.

OBSERVATIONS

The authors report a case of a girl who presented with an abnormal head shape and bilateral squamosal synostosis. Genetic testing revealed a chromosome 1p12–1p13.3 deletion. She has been managed with conservative treatment of the synostosis. She has global developmental delay and multiple anomalies due to the chromosome abnormality.

LESSONS

Isolated squamosal suture synostosis could be an uncommon feature of chromosome 1p12–1p13.3 deletion.
Peresepan Obat “Off-Label” Pada Anak Dengan Penyakit Infeksi Saluran Pernapasan Akut
Authors: Putra Oki Nugraha , Anggraini Eri Destin , Faizah Ana Khusnul
Published: January 2021

ABSTRAKInfeksi Saluran Pernapasan Akut (ISPA) termasuk penyakit yang banyak terjadi di Indonesia terutama pada usia anak. Pada populasi anak berisiko mendapatkan peresepan obat off-label dikarenakan terbatasanya data efikasi obat untuk anak. Penggunaan obat off-label meningkatkan risiko efek yang tidak dikehendaki. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat secara off-label pada peresepan pasien ISPA anak. Penelitian ini merupakan penelitian deskriptif observasional dengan menggunakan desain cross-sectional. Pengumpulan data menggunakan peresepan obat dengan diagnosis ISPA  pada anak usia 0-18 tahun. Penelitian ini dilakukan pada bulan November 2019 sampai dengan Februari 2020. Pada` penelitian ini didapatkan 124 resep dengan diagnosis ISPA. Penggunaan obat off-label pada peresepan penyakit infeksi saluran pernapasan akut untuk pasien anak sebesar 23% dengan kategori off-label usia (15,67%), off-label dosis (5,70%), off-label rute pemberian (1,22%) dan off-label indikasi (0,40%). Jenis obat off-label paling banyak diresepkan untuk ISPA anak adalah antihistamin klorfeniramin maleat. Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa penggunaan obat off-label pada penyakit ISPA anak cukup tinggi. Farmasis dan dokter dapat berkolaborasi untuk pemantauan penggunaan obat yang tergolong off-label. Penelitian lanjutan diperlukan untuk melihat korelasi atau faktor risiko yang berpotensi meningkatkan penggunaan off-label pada ISPA anak. Kata kunci : Obat off-label; ISPA; Peresepan; Anak. ABSTRACTAcute respiratory tract infections (ARTI) is a disease that often occurs in Indonesia, especially in children. The population of children is high risk of receiving off-label prescription drugs. The use of off-label drugs increases the risk of undesirable effects. This study was aimed to evaluate the off-label use of drugs in prescribing with acute respiratory tract infection. This research is a descriptive observational study using a cross-sectional design. Data was collected by the prescription in children aged 0-18 years old with acute respiratory tract infection. This study was conducted from November 2019 to February 2020. In this study, 124 prescriptions were obtained with a diagnosis of ARTI. The use of off-label drugs was 23% with the off-label age category (15.67%), off-label dose (5.70%), off-label route of administration (1.22%) and off-label indication (0.40%). The type of off-label drug most commonly prescribed in children with ARTI is chlorpheniramine maleate. It can be concluded that the use of off-label drugs in children with ARTI disease is quite high. Pharmacists and clinicians should collaborate each other to monitor the use of drugs that are classified as off-label. Further research is needed to analyze   correlations or risk factors that potentially may increase off-label use in children with ARTI.Keywords : Off-label drugs; Acute Respiratory Tract ; Infection; Prescribing; Children.
Prognostic significance of longitudinal evaluation on egfr mutant ctdna during tki treatment in nsclc
Authors: Moiseenko F.V. , Volkov, N.M. , Zhabina, A.S. , . Stepanova, M.L. , . Rjsev N.A. , Klimenko V.V. , Myslik A.V. , Artemieva E.V. , Abduloeva N.H. , Egorenkov V.V. , . Moiseyenko V.M.
Published: January 2021

Detection of EGFR mutations in tumor tissue is the gold standard for prescribing tyrosine kinase inhibitor therapy.However even in the same molecularly defined population effect of the treatment, response duration and survival might differ significantly. We did a prospective clinical trial to assess ctDNA-based EGFR mutations as a prognostic marker for patients with lung adenocarcinoma receiving TKI as first-line treatment.
Immune checkpoint inhibitors in the treatment of cervical cancer: literature review
Authors: Pardabekova O.A.
Published: January 2021

The incidence and mortality from cervical cancer (CC) remains high. There are few effective options among chemotherapeutic agents for the treatment of recurrent and metastatic CC. One of the novel therapeutic approaches is to induce anti-cancer immunity by immune checkpoint inhibitors (ICI). The search for prognostic biomarkers to improve the efficacy of immunotherapy is ongoing. The efficacy and safety of ICI, either used as monotherapy or in combination with chemotherapy, radiation therapy, is being evaluated in several clinical studies. Early results are promising, making ICI an important field of research in the development of novel therapies for CC.
Overdiagnosis of thyroid cancer
Authors: Zaridze D.G. , Stilidi I.S. , Kaprin A.D. , Maksimovich D.M.
Published: January 2021

Overdiagnosis is the main «driver» of the growing epidemic of thyroid cancer in the world. More than half of cases of thyroid cancer in women are the result of overdiagnosis, i.e. diagnosis of a tumor, the probability of progression and metastasis of which is extremely low. Our analysis showed that the incidence of thyroid cancer in Russia and most of its administrative regions is growing. At the same time, we observe pronounced interregional variability in the incidence rate. A very highage adjusted incidence rate, especially among women, is registered in the Bryansk region and other high-risk regions. The main cause of the increase in the incidence of thyroid cancer in the regions adjacent to the Chernobyl nuclear power plant is exposure to radioactive iodine (131I ) in childhood and adolescence. However, an increase in the incidence of thyroid cancer in this region at least partly is a consequence of ultrasonography (US) screening and the identification of clinically insignificant lesions. Only 40% of cases of thyroid cancer detected as a result, of screening could be the attributed to radiation. Accordingly, 60% are latent tumors that would never have clinically shown themselves if they had not been identified as a result, of screening.Altai region is also considered a high-risk region because it borders with the Semipalatinsk region of Kazakhstan the region where the former Soviet nuclear test site was located. Inthe Altai region, the introduction of US screening led to an increase in the detection of thyroid cancer from 8,7% in 1992 to 20,3% in 1999. A marked increase in incidence in Russia, the increase in incidence in middle age and as a result the change in expected exponential pattern of age-specific curve into inverted «U», a very high incidence to mortality ratio, a very high cancer survival rate, which statistically significantly correlates with incidence, a statistically significant correlation between the proportion of tumors detected at the first stage and the incidence of thyroid cancer, a statistically significant correlation between prevalence of thyroid cancer and the incidence is a clear evidence of overdiagnosis. We estimate that the number of overdiagnosed thyroid cancer in Russia over 27 years ranges from 99000 to 138000 cases. We do not have sufficient retrospective data to estimate more accurately the size of thyroid cancer overdiagnosis in Russia. Thyroid cancer incidence data for Russia overall is available only from 1989.
Models for the Design and Operation of Digital Educational Environments
Authors: Solovov A. V. , Menshikova A. A.
Published: January 2021

Many educational institutions, assessing their prospects, plan to develop distance educational services using their own electronic and information educational environments (EIEE). During creating and operating EIEE of educational institution (EI), a number of questions arise related to structural, marketing, personnel and other decisions. The purpose of this article is to research the organizational, technical and didactic aspects of the EIEE EI. The methodology of the research is based on methods of system analysis, cybernetics, pedagogical psychology and didacticism.

A conceptual model of the EIEE EI as an organizational and technical system has been proposed. It includes a marketing subsystem, a set of technical tools, various types of security and an organizational subsystem. The main functions of these subsystems and their various components have been identified.

A didactic model of a typical complex of digital educational resources has been developed. Within this model, the diversity of digital educational resources across each academic discipline is integrated into complexes that provide a complete study at different target levels of assimilation, from initial acquaintance to solving uncharacteristic professionally oriented tasks.

From the point of view of pedagogical psychology and cybernetics, the high importance of feedback in EIEE EI is shown. The classification of feedbacks (internal and external) is proposed for the triad “Teacher – Teaching Program – Learner”. The limits of the use of automation in the formation of feedbacks are specified, as opposed to other (non-computer) responses to students’ educational activities. The role and place of feedback in the “digital footprints” of students and teachers is shown and the directions for the use of this data in artificial intelligence systems are outlined.
Safety aspect of intraoperative, local urokinase lysis in patients with acute lower limb ischemia
Authors: Schierling Wilma , Bachleitner Kathrin , Kasprzak Piotr , Betz Thomas , Stehr Alexander , Pfister Karin
Published: January 2021

BACKGROUND: Acute lower limb ischemia (ALI) is associated with a high risk of limb loss and death. OBJECTIVE: The present study evaluates the safety of intraoperative, local urokinase lysis in patients with ALI and crural artery occlusion. METHODS: A total of 107 patients (115 legs) were treated surgically for ALI with additional intraoperative urokinase lysis to improve the outflow tract. Minor and major bleeding as well as efficacy of treatment and amputation-free survival were investigated. RESULTS: Complete restoration of at least one run-off vessel was achieved in 64%. Collateralization was improved in 34%. Lysis failed in 2%. Major amputation rate was 27% overall (12% within 30 days) and depended on Rutherford class of ALI (overall/30 day: IIa 11%/6%; IIb 20%/17%; III 37%/15%). Amputation-free survival turned out to be 82% after 30 days, 58% after one, and 41% after five years. Minor bleeding occurred in 21% (24/115) and major bleeding in 3.5% (4/115). One of these patients died of haemorrhage. No patient experienced intracranial bleeding. CONCLUSION: Intraoperative urokinase lysis improves limb perfusion and causes low major and intracranial bleeding. It can be safely applied to patients with severe ischaemia when surgical restoration of the outflow tract fails.
A gating context-aware text classification model with BERT and graph convolutional networks
Authors: Gao Weiqi , Huang Hao
Published: January 2021

Graph convolutional networks (GCNs), which are capable of effectively processing graph-structural data, have been successfully applied in text classification task. Existing studies on GCN based text classification model largely concerns with the utilization of word co-occurrence and Term Frequency-Inverse Document Frequency (TF–IDF) information for graph construction, which to some extent ignore the context information of the texts. To solve this problem, we propose a gating context-aware text classification model with Bidirectional Encoder Representations from Transformers (BERT) and graph convolutional network, named as Gating Context GCN (GC-GCN). More specifically, we integrate the graph embedding with BERT embedding by using a GCN with gating mechanism to enable the acquisition of context coding. We carry out text classification experiments to show the effectiveness of the proposed model. Experimental results shown our model has respectively obtained 0.19%, 0.57%, 1.05% and 1.17% improvements over the Text-GCN baseline on the 20NG, R8, R52, and Ohsumed benchmark datasets. Furthermore, to overcome the problem that word co-occurrence and TF–IDF are not suitable for graph construction for short texts, Euclidean distance is used to combine with word co-occurrence and TF–IDF information. We obtain an improvement by 1.38% on the MR dataset compared to Text-GCN baseline.
Aggregation operators of Pythagorean fuzzy soft sets with their application for green supplier chain management
Authors: Zulqarnain Rana Muhammad , Xin Xiao Long , Garg Harish , Khan Waseem Asghar
Published: January 2021

The Pythagorean fuzzy soft sets (PFSS) is a parametrized family and one of the appropriate extensions of the Pythagorean fuzzy sets (PFS). It’s also a generalization of intuitionistic fuzzy soft sets, used to accurately assess deficiencies, uncertainties, and anxiety in evaluation. The most important advantage of PFSS over existing sets is that the PFS family is considered a parametric tool. The PFSS can accommodate more uncertainty comparative to the intuitionistic fuzzy soft sets, this is the most important strategy to explain fuzzy information in the decision-making process. The main objective of the present research is to progress some operational laws along with their corresponding aggregation operators in a Pythagorean fuzzy soft environment. In this article, we introduce Pythagorean fuzzy soft weighted averaging (PFSWA) and Pythagorean fuzzy soft weighted geometric (PFSWG) operators and discuss their desirable characteristics. Also, develop a decision-making technique based on the proposed operators. Through the developed methodology, a technique for solving decision-making concerns is planned. Moreover, an application of the projected methods is presented for green supplier selection in green supply chain management (GSCM). A comparative analysis with the advantages, effectiveness, flexibility, and numerous existing studies demonstrates the effectiveness of this method.
Subdural extravasation of crystalloids and blood products through a scalp peripheral intravenous catheter into the subdural space of a neonate on veno-arterial extracorporeal membrane oxygenation
Authors: Fleiss N. , Klein-Cloud R. , Gill B. , Feldstein N.A. , Fallon E.M. , Ruzal-Shapiro C. , Collins A.
Published: January 2021

We describe a rare and devastating complication of a malpositioned scalp peripheral intravenous catheter (PIV) that resulted in subdural extravasation of infused fluids and midline shift in a critically ill neonate who required extracorporeal membrane oxygenation (ECMO). Recognition of increased intracranial pressure was hindered by the hemodynamic changes of being on ECMO and only identified by routine surveillance ultrasonography. Awareness of this complication may lead providers to seek alternate sites for vascular access in such patients, and encourage closer monitoring for this complication when an alternate site is unavailable.
Evaluating the impact of CPAP weaning procedures on total days on nasal CPAP: A retrospective chart review
Authors: Puthattayil Z.B. , Moore G.P. , Tang K. , Huneault-Purney N. , Lawrence S.L.
Published: January 2021

BACKGROUND:

There is no consensus on how to wean infants from Nasal Continuous Positive Airway Pressure (NCPAP). We hypothesized that ceasing NCPAP abruptly would decrease the duration required, compared with a gradual wean.

METHODS:

This retrospective chart review included preterm infants requiring NCPAP for over 48 hours. Cohort1 weaned NCPAP by cycling on and off, while cohort 2 ceased NCPAP abruptly. The primary outcome was total days on NCPAP. Secondary outcomes included rate of bronchopulmonary dysplasia, weight gain, duration of hospital stay, and compliance with the use of stability criteria.

RESULTS:

81 infants met inclusion criteria in cohort one, and 89 in cohort two. Median days on NCPAP were 17.0 and 11.0 days, respectively, not significant. There was no significant difference in secondary outcomes.

CONCLUSIONS:

There was no significant association between the two NCPAP weaning protocols and the outcomes studied.
Involvement in the organized market of such forms of self employment in rural areas as personal subsidiary farms of citizens
Authors: Kot Ekaterina , Zyryanova Tat'yana , Zyryanov Sergey
Published: January 2021

Abstract. Within the framework of a set of measures for the implementation of the national project on small and medium-sized enterprises and support for individual entrepreneurial initiative in accordance with the Decree of the President of the Russian Federation on national goals and strategic development tasks, the importance of involving citizens in independent production activities is reflected. In this regard, Federal Law No. 422-FL of 27 November 2018 (hereinafter referred to as the Law) initiated a tax experiment to establish a new special tax regime “Tax on Professional Income” (hereinafter referred to as the TPI). The purpose of the study is to determine the economic impact of the new tool on the involvement in economic turnover of such a form of self-employment in rural areas as personal subsidiary farms of citizens. Tasks: 1) using the deductive method of theoretical research to analyze the effect of the experiment on the application of the new special tax regime on the territory of Russia; 2) to consider in practical situations the options for applying the TPI for self-employed citizens; 3) systematize data on the calculation of naps in the form of a model that has theoretical and practical significance for the involvement of private subsidiary farms (hereinafter referred to as PSF) in an organized market. Research methods: deduction, axiomatic, analysis, synthesis, comparison, experiment, measurement. The scientific novelty and results is that according to the Law, a new target group is allocated – self-employed citizens who indicate services in different fields of activity. In agriculture, it is also necessary to direct the activities of PSF that sell their own products to an organized market. Results. In order to help improve financial literacy with the support of self-employed entrepreneurs, a comparative analysis of deductions for the calculation of professional income tax was conducted. Algorithms for calculating naps have been developed, which are the basis for considering practical situations. A model has been compiled that systematizes the procedure for applying the TPI for self-employed citizens.
Features of management of advertising activities of an agricultural holding
Authors: Lysenko Yuliya , Buhtiyarova Tat'yana , Butko Galina , Belokonov Yuriy
Published: January 2021

Abstract. Relevance. Currently, agroholdings actively use advertising to increase the recognition of agro-products, since advertising effectively affects the target segment, gives consumers new knowledge and opportunities to choose alternative products, which in turn increases satisfaction from purchase. Purpose. The article presents the main provisions of the development of measures aimed at improving the advertising activities of agricultural holdings (using the example of grain specialization). Methods. Among the common promotion methods, the authors distinguish the following: printing materials, online advertising, service, gift certificates, promotions, outdoor advertising. The current system of intra-company advertising was diagnosed and recommendations were made to improve the organization and planning of grain specialization advertising: the development of social networks, creative outdoor advertising. The main research methods are horizontal and vertical analysis, comparison and grouping methods. The proposed recommendations are supported by calculations, the forecast values of indicators and their relationship with the sale of agricultural products are indicated. Scientific novelty. In the analysis of intra-company advertising, it was established that a decrease in the use of advertising funds leads to the fact that the invested funds in advertising do not bring the expected results and show a decrease in the effectiveness of advertising. To solve the problem, the author developed a system of events: the creation of a creative advertising campaign in a magazine, creative outdoor advertising. Results. With increased investment in advertising, the return on investment ratio increases at a much faster pace, which indicates the advantage of online advertising and an increase in the number of visitors and buyers, an increase in profitability by more than 15 percent, and an increase in the level of attention of buyers to advertising will increase to 61 percent by 2022.
The main problems of processing livestock products in the Republic of Kazakhstan
Authors: Sadu Zhanna , Kushebina Gul'nara , Kuhar' V.
Published: January 2021

Abstract. Objective. Identification, assessment and solution of the main problems of livestock processing enterprises in the Republic of Kazakhstan. Methods. In the course of the study, analytical and economic-statistical methods, general scientific methods of systemic, comparative and structural-logical analysis were applied. Results. The article presents the results of the assessment of the current situation processing of livestock products in the Republic of Kazakhstan, the dynamics of dairy production for 2015–2019, which have a significant effect on the production direction of the industry, the regional location of the dairy enterprises, security at the expense of domestic production, exports and imports of milk and dairy products. The main problems of the milk processing industry are identified. Measures of state support for the processing of agricultural products are disclosed in order to ensure maximum utilization of processing enterprises, increase the share of processing of agricultural raw materials and increase the competitiveness of domestic products in the domestic and foreign markets. The current situation of meat processing enterprises in terms of their number and workload in the context of regions and in the republic as a whole is studied. The article presents the dynamics of the production of sausage products, canned meat and meat-growing products, security due to domestic production, as well as the export and import of meat products. The main problems and a number of measures of state support for the meat industry implemented by the state are indicated. Trends in the development of agricultural processing enterprises within the framework of the main state programs for the development of the meat industry of the Republic of Kazakhstan are presented. The scientific novelty lies in the study of the problems of processing livestock products in the Republic of Kazakhstan and the definition of the main directions of state support for processing enterprises in the livestock industry.
MEMBENTUK ENTREPRENEUR GENERASI MUDAUNTUK MEMBANGUN PERCAYA DIRI DALAM MENGHADAPI TANTANGAN MASA DEPAN PADA YAYASAN ISHLAHUL HAYAT RUMAH YATIM & DHUAFA KELURAHAN BAMBU APUS KECAMATAN PAMULANG TANGERANG SELATAN
Authors: . Maswarni , Andriani Jeni , Wulansari Retno , Sampurnaningsih Sri Retnaning , Susanti Novia
Published: January 2021

“Membentuk Entrepreneuer Generasi Muda untuk Membangun Percaya Diri DalamMenghadapi Tantangan Masa Depan”, Pada Yayasan Ishlahul Hayat, Rumah Yatim & Dhuafa Kelurahan Bambu Apus Kecamatan Pamulang Tangerang Selatan. Tujuan dari Pengabdian kepada Masyarakat (PKM) ini adalah untuk membentuk entrepreneur muda, dengan cara membangun percaya diri, sehingga dapat menghadapi tantangan masa depan. Pengabdian dilakukan kepada para guru dan anak didik/asuhan Yayasan Ishlahul Hayat melalui penyuluhan mengenai motivasi dan kreatifitas , serta pembuatan kerajinan (craft) decoupage. Adapun mitra PKM adalah Yayasan Ishlahul Hayat, Rumah Yatim & Dhuafa di Jalan Mujair Raya Kelurahan Bambu Apus Kecamatan Pamulang Tangerang Selatan.Metode yang digunakan dalam PKM ini adalah penyuluhan tentang motivasi dan kreatifitas serta pelatihan membuat kerajinan (craft) decoupage. Hasil dari pelaksanaan PKM ini, diharapkan anak asuhan Yayasan Ishlahul Hayat, Rumah Yatim & Dhuafa di Jalan Mujair Raya Kelurahan Bambu Apus Kecamatan Pamulang Tangerang Selatan mampu membuat kerajinan (craft) decoupage sehingga dapat membentuk entrepreneur yang terampil, mandiri dan kreatif, serta dapat meningkatkan percaya diri serta siap menghadapi tantangan masa depan,menuju kehidupan yang lebih cemerlang.
KEPEMIMPINAN PERSPEKTIF ALQURAN; INTERPRETASI SEMIOTIK QS. AL-BAQARAH (2): 30-34
Authors: Andi Azhari
Published: January 2021

Discourse of leadership is always facual and actual to be discussed. It is increasingly discussed by Indonesian in which general elction is coming up this year. This article attempts to examine discourse of leadership on QS. Al-Baqarah 2 / 30-34 which is analyzed through semiotic perspective that is introduced by Charles Sander Pierce. The article finds that requirement of being khalifah which is discussed by Q. 2/31-34 is having knowledge. Besides, spiritual piety is needed to become khalifah but not as significant as having knowladge.  In the other hand, the Qur'an, by Q. 2/31-34, criticizes that to become a leader is not depending on lineage factors and spiritual piety (only).
EKSISTENSI DISABILITAS DALAM PROFESIONALITAS KERJA PERSPEKTIF ALQURAN
Authors: Marhaban Nawawi , Lestari Lenni , Sani Alfian , Baiti Nur
Published: January 2021

This article discusses the existence of disability in shaping the professional attitude of the Qur'anic perspective. By preserving the story of Abdullah bin Ummi Maktum narrated in Surat 'Abasa, the Qur'an does not differentiate between normal people and those with disabilities, and not discriminate against one another. Not only acknowledging the existence of disability, the Qur'anic concept also explains how to behave and associate with them as being responsive and courteous, other dispensations that the Qur'an gives to disability. Although people with disabilities are not physically perfect, they have certain skills and skills that can be sharpened and developed, so that it can give birth to a professional attitude of work that does not see the physical.
Efektivitas effleurage massage terhadap pencegahan postpartum depression pada ibu nifas di PMB Elizabeth Banyuanyar Surakarta
Authors: Hapsari Erlyn , Rumiyati Eni , Astuti Hutari Puji
Published: January 2021

Latar Belakang: Depresi postpartum di Indonesia berkisar 11-30%, yang berdampak tidak baik pada kesehatan ibu, anak dan keluarga karena menyebabkan penurunan kemampuan dalam mengasuh anak, ketertarikan pada bayinya kurang, tidak berespon baik/positif terhadap bayinya dan ibu menjadi malas menyusui sehingga akan mempengaruhi kesehatan, pertumbuhandanperkembangan bayi. Tujuan penelitian ini untuk mengetahui efektivitas effelurage massage terhadap pencegahan postpartum depression pada ibu nifas di PMB Elisabeth Banyuanyar Surakarta. Metode penelitian ini menggunakan quasi eksperimen dengan desain one group pre-test and post-test. Subjek penelitian adalah ibu yang menjalani terapi effleurage massage di PMB Elizabeth Banyuanyar Surakarta. Sampel diambil dengan teknik purposive. Teknik pengumpulan data menggunakan observasi, dan kuesioner. Teknik analisis data menggunakan analisis deskriptif, dan inferensial dengan uji Wilcoxon. Hasil : (1) Tingkat depresi ibu pospartum sebelum menjalani effleurage massage yaitu : ada 40% dengan kategori tidak depresi, 20% mungkin depresi, dan 40 % mengalami depresi. (2) Tingkat depresi ibu pospartum setelah menjalani effleurage massageberkurang yaitu ada 60% responden sudah tidak mengalami depresi, 40% responden mungkin depresi dan tidak ada yang mengalami depresi. Simpulan : Ada perbedaan yang signifikan antara tingkat depresi sebelum dan setelah ibu pospartum menjalani effleurage massagedengan nilai probabilitas (p) 0,034 0,05.
Perubahan psikologis pasca aborsi premarital pada remaja
Authors: Mulyanti Lia
Published: January 2021

Latar belakang: Berkembangnya pola hidup seks bebas menimbulkan dampak semakin banyaknya kasus kehamilan yang tidak diinginkan terutama pada remaja. Kejadian kehamilan yang tidak diinginkan menuntut para pelaku seks bebas berusaha mencari solusi dari permasalahan yang sedang dihadapi. Sebagian perempuan terutama remaja yang mengalami kehamilan yang tidak dinginkan mencari temapat pelayanan aborsi yang tidak terlepas dari legalitas aborsi maupun ketersediaan pelayanan aborsi yang aman. Beberapa kejadian kehamilan yang tidak diinginkan berakhir dengan kelahiran tetapi beberapa diantaranya diakhiri dengan abortus. Abortus adalah ancaman atau pengeluaran hasil konsepsi sebelum janin dapat hidup di luar kandungan  sebagai batasan usia kehamilan kurang dari 20 minggu atau berat janin kurang dari 500 gram, sedangkan menurut WHO batasan usia kehamilan saat melakukan tindakan abortus adalah sebelum usia kehamilan 22 minggu Tujuan penelitian: Untuk mengetahui perubahan psikologis pada remaja yang telah melakukan aborsi pada kehamilannya. Metode: Penelitian ini menggunakan pendekatan kualitatif dengan desain studi kasus untuk mengumpulkan informasi secara mendalam tentang bagaimana perunahan psikologis pada remaja pasca melakukan tindakan aborsi. Hasil: Dari hasil deep interview yang dilakukan kepada 5 responden remaja yang melakukan aborsi didapatkan bahwa kelima responden mengungkapkan bahwa muncul perasaan depresi, kehilangan percaya diri Simpulan: Perubahan psikologis yang terjadi pada remaja yang melakukan aborsi dimana mereka merasa menyesal telah melakukan tindakan aborsi dan hanya mementingkan diri sendiri dan reputasi dirinya terhadap pandangan orang lain
Pengaruh delay cord clamping terhadap ikterus neonatorum
Authors: K. Rahayu Eryanti , Simbung Rismawati , Saleng Hasriani , Sudirman Jumrah
Published: January 2021

Latar belakang: Ikterus merupakan suatu kondisi yang ditandai dengan hiperbilirubin. Ikterus dapat terjadi pada saat bayi lahir dan setiap saat selama masa neonatus. Dampaknya apabila berlanjut berupa ketulian, gangguan bicara, retardasi mental serta kerusakan otak. Waktu penjepitan tali pusat berperan penting dalam menentukan kecukupan zat besi pada bayi baru lahir terutama saat proses transfusi plasenta. Tujuan penelitian : Diketahuinya pengaruh delay cord clamping terhadap kejadian ikterus neonatorum. Metode : Desain penelitian menggunakan Quasi Eksperimen dengan pendekatan posttest only. Perlakuan dilakukan pada 2 kelompok dengan penundaan 1 menit dan 2 menit masing-masing 17 sampel. Populasi seluruh bayi baru lahir di Puskesmas Bara-Baraya dan Puskesmas Pattingaloang pada tanggal 08 Juli- 24 September 2020. Jumlah sampel 34 bayi baru lahir yang diambil secara purposive sampling. Instrumen menggunakan lembar observasi. Data dianalisis dengan menggunakan uji Chi-Square dengan tingkat kesalahan ɑ = 0,05. Hasil : Hampir seluruhnya bayi dengan penundaan penjepitan tali pusat 2 menit tidak Ikterus 88,2%, ikterus fisiologis 11,8% dan tidak ada yang ikterus patologis. Dan persentase pada penundaan penjepitan tali pusat 1 menit ikterus patologis 35,3%, ikterus fisiologis 17,6% dan tidak ikterus 47,1%. Hasil uji Chi-Square menunjukkan ada pengaruh delay cord clamping terhadap kejadian ikterus neonatorum (p=0,008). Simpulan: Ada pengaruh delay cord clamping terhadap kejadian ikterus neonatorum.
PATTERNS OF HISTOMORPHOLOGICAL VARIANTS OF SKIN DISEASES IN A RURAL TERTIARY CARE CENTRE
Authors: Nema S.K. , Verma Sneha , Narang Sanjeev
Published: January 2021

Background: Skin biopsy is a common procedure in Dermatology practice. The usual intent of skin biopsy is to further characterize the nature of a skin growth or eruption and assist in diagnosis by allowing histopathological evaluation of a tissue sample. Although histopathology remains the gold standard for most dermatologic diagnoses, it must be recognized that not all lesions are amenable to definitive specific histological diagnosis1.

Material & Methods: The present study is undertaken in the department of Pathology, Index Medical College Hospital and Research Center, Indore (M.P). This was a cross sectional observational study which included skin biopsy specimen from 122 cases reported for histopathological evaluation attending Skin & VD OPD of the institute from June 2018 to Feb 2020. On the basis of histopathological features these skin disorders were classified in different groups as per Lever’s classification2.

Results: out of 116 cases included in the study, maximum cases belonged to group III (n=43) followed by group V (n=38), group IV (n=11), group I (n=7), group II (n=7), group VI (n=7) and group VII (n=3). Overall most common disease observed was Psoriasis followed by Leprosy. Highest number of cases were found in age group 41-50 years (n=25) and clinicopathological correlation was seen in 79.09% cases.

Conclusion: The skin biopsy and subsequent histopathological examination has been proved as gold standard for identifying a specific dermatoses and appropriate management, being most cost effective tool.

Keywords: Skin, Histopathology, Psoriasis, Leprosy
HISTOPATHOLOGICAL STUDY OF BENIGN AND MALIGNANT LESIONS OF UTERUS AND CERVIX IN HYSTERECTOMY SPECIMENS
Authors: Raghuwanshi Shikha , Bhadouria Dharmendra Singh , Raghuwanshi Surendra , Saxena Arun , Nema S.K.
Published: January 2021

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center.

Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination.

Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases.

Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions.

Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy
Application Research Progress of Neuromodulation Technology in the Treatment of Freezing Gait in Parkinson's Disease
Authors: Shi Guolin , Zhao Ninghui , Wu Tingting
Published: January 2021

Freezing gait is a common clinical symptom in patients with Parkinson's disease. It tends to get worse with the progress of the disease, causing the patients to fall easily, which is one of the important reasons for the loss of independent living ability. The treatment of frozen gait is very complicated, and drug treatment has no obvious effect. Neuromodulation technology is currently an effective method for clinical treatment of frozen gait in Parkinson's disease. This technology mainly uses implantable devices and non-implantable devices, and uses electrical or chemical methods to correct frozen gait, which helps to improve the quality of life of patients with Parkinson's disease. This article focuses on the application research of neuromodulation technology in the treatment of freezing gait in Parkinson's disease.
Optimalisasi Waktu Produksi, Jumlah Produksi, Dan Jalur Distribusi Pada Oulet Lazatto di Karawang
Authors: Lestari Cici , Sari Rianita Puspa
Published: January 2021

The development of the food and beverage business is still recorded as a number of high developments in this world, the types of food and beverage in various forms have increased because food is one of the basic needs that must be met. Lazatto is a food industry that is engaged in various fields of fast food restaurants by producing processed chicken. The problems that occur at Lazatto are the inability to maximize the amount of chicken production, optimize the production time for employees, and the distribution channel to determine the shortest route to utilize raw materials. The purpose of this research is to analyze the optimization of working time using the Hungarian method or assignment, the amount of production using the Branch and Bound method, and the distribution line using the Minimum Spanning Tree method. The results showed that the optimal working time is 83 minutes or 1 hour 23 minutes / one time production, the amount of production in one production is 23 pieces with a combination of 5 pieces of geprek chicken, 4 pieces of sadas chicken, and 14 pieces of fried chicken, with The optimal total distance for the distribution of raw materials is 137.6 km.
Метод инцизионной биопсии в диагностике заболеваний слизистой оболочки полости рта
Authors: Рутковская А.С. , Ленькова И.И. , Александрова Л.Л. , Казеко Л.А. , Бич Т.А.
Published: January 2021

Морфологическое исследование биопсийного материала является наиболее информативным методом для постановки окончательного диагноза и проведения дифференциальной диагностики поражений слизистой рта.
Цель исследования – разработать оптимальный метод инцизионной биопсии слизистой оболочки полости рта, позволяющий предотвратить артифициальные изменения и пространственную деформацию гистологического материала.
Объекты и методы исследования. Для демонстрации эффективности разработанного метода инцизионной биопсии и морфологической верификации клинического диагноза у 27 пациентов с различными поражениями слизистой рта проведен забор биопсийного материала в условиях хирургического стоматологического кабинета ГУ ≪Республиканская клиническая стоматологическая поликлиника≫. Стоматологическое обследование пациента проводилось согласно рекомендациям ВОЗ (2013г.) с детальной оценкой состояния слизистой, выявлением факторов риска, очагов одонтогенной инфекции и соматических заболеваний. Предварительный клинический диагноз устанавливали согласно международной классификации болезней (МКБ-10, 1997г.). Предложенный метод инцизионной биопсии содержит клиническую и морфологическую части. Клиническая часть включает: проведение инфильтрационной анестезии; прицельное выделение, иссечение и удержание биоптата в расправленном виде с его дальнейшим погружением в 10%-й раствор забуференного нейтрального формалина; наложение швов и ведение послеоперационного периода. Морфологическая часть включает: обработку биопсийного материала с изготовлением гистологических препаратов; их морфологическую оценку и заключение.
Результаты исследования и их обсуждение. Результатом использования предложенного метода стало установление объективного морфологического диагноза в 92,6% случаев. Артифициальные изменения биопсийного материала, такие как смещение инцизионного участка СОПР и механическое повреждение биоптата, отмечены в 7,4% случаев.
Заключение. Предложенный метод инцизионной биопсии слизистой рта позволяет: получить информативный гистологический материал для последующей оценки патогистологических признаков поражения слизистой; предотвратить артифициальные изменения гистологического материала; поставить окончательный морфологический диагноз; провести дифференциальную диагностику патологических состояний, сопровождающихся наличием элементов поражения на слизистой оболочке полости рта.
Возбудители одонтогенных и неодонтогенных воспалительных заболеваний челюстно-лицевой области
Authors: Кабанова А.А. , Гончарова А.И. , Окулич В.К.
Published: January 2021

Цель исследования. Провести сравнительный анализ спектра возбудителейбодонтогенных и неодонтогенных воспалительных заболеваний челюстно-лицевой области.
Объекты и методы исследования. Проведен анализ результатов бактериологического исследованиябгнойного очага у 494 пациентов с воспалительными заболеваниями челюстно-лицевой области,бнаходившихся на стационарном лечении в стоматологическом отделении УЗ ≪Витебская областная клиническая больница≫. Из общего числа исследуемых нозологий выделены воспалительные заболевания одонтогенной этиологии: острый гнойный одонтогенный периостит челюсти, одонтогенный абсцесс челюстно-лицевой области, острый одонтогенный остеомиелит челюсти, осложненный флегмоной прилежащих клетчаточных пространств. К патологии неодонтогенной этиологии были отнесены фурункулы, травматический остеомиелит нижней челюсти, сиаладениты. Клинические изоляты микроорганизмов выделяли, следуя инструкции по применению № 075-0210 ≪Микробиологические методы исследования биологического материала≫, утвержденной Министерством Здравоохранения Республики Беларусь 13.03.2010 г. Выделено 430 изолятов микроорганизмов.
Результаты исследования и их обсуждение. При анализе спектра возбудителей воспалительных заболеваний выявлено, что в этиологической структуре преобладают стрептококки и стафилококки. При этом преобладание одних над другими зависит от конкретной нозологии. Так, при развитии травматического остеомиелита челюсти, данное соотношение составило 30%/56%, что указывает на ведущую роль стафилококков. При развитии фурункула основным возбудителем является золотистый стафилококк (86%), при развитии сиаладенита – 46% стрептококков и 33% стафилококков. Одонтогенные воспалительные заболевания также связаны с ассоциациями стафилококков и стрептококков. При этом при развитии одонтогенного периостита челюсти преобладают стрептококки над стафилококками (69% и 25% соответственно). В этиологической структуре одонтогенных абсцессов идентифицировано 68% стафилококков и 20% стрептококков, при развитии флегмон выделено практически равное количество стрептококков и стафилококков.
Заключение. Следовательно, стафилококки и стрептококки, в меньшей степени энтерококки, являются основными аэробными возбудителями одонтогенных и неодонтогенных воспалительных заболеваний челюстно-лицевой области.