bluuebunny/crossref_metadata_2025 huggingface dataset:
Προσδιορισμός απόστασης πυροβολισμού από βραχύκαννα ραβδωτά πυροβόλα όπλα (πιστόλια), καθώς και λειόκαννα κυνηγητικά όπλα (καραμπίνες)
Authors: Κωστορρίζος Αθανάσιος
Published: July 2024

Σκοπός της έρευνας είναι να δώσει απαντήσεις σε ερωτήματα που τίθενται από τις προανακριτικές ή δικαστικές αρχές ή ανακύπτουν κατά την νεκροψία και νεκροτομή, σχετικά με τον προσδιορισμό της απόστασης πυροβολισμού με τη χρήση ραβδωτών πυροβόλων όπλων και συγκεκριμένα πιστολίων, διαμετρήματος 9mm Parabellum, από αποστάσεις μικρότερες ή ίσες των πέντε (5) μέτρων, καθώς και λειόκαννων κυνηγετικών όπλων, διαμετρήματος 12 Gauge, από αποστάσεις 10, 18 και 25 μέτρων. Όσον αφορά την έρευνα για τον προσδιορισμό της απόστασης πυροβολισμού με τη χρήση ραβδωτών πυροβόλων όπλων (πιστολίων) αυτή επικεντρώθηκε στη μελέτη 143 ανθρωποκτονιών που έλαβαν χώρα από τα έτη 2008 – 2017, στην περιοχή του Νομού Αττικής, όπου επιλέχτηκαν 27 υποθέσεις με 31 θύματα ανθρωποκτονίας. Η καταγραφή των τραυμάτων έδειξε ότι όταν ο πυροβολισμός που πραγματοποιείται από απόσταση μικρότερη ή ίση των πέντε (5) μέτρων, ένα σημαντικό ποσοστό των τραυμάτων είναι διαμπερή, ποσοστό το οποίο κυμαίνεται ανάλογα με την ανατομική περιοχή. Τα ευρήματα της νεκροψίας και νεκροτομής όλων των θυμάτων που εξετάσθηκαν, η μελέτη του προανακριτικού υλικού, καθώς και το ποσοστό των διαμπερών και τυφλών τραυμάτων καταγράφηκαν σε πίνακες, οι οποίοι παρέχουν χρήσιμες πληροφορίες στους εξεταστές για τον προσδιορισμό της απόστασης πυροβολισμού. Τέλος, όσον αφορά την υλοποίηση του σκοπού για τον προσδιορισμό της απόστασης πυροβολισμού με τη χρήση λειόκαννων κυνηγετικών όπλων, διαμετρήματος 12 Gauge, διενεργήθηκαν εκατό σαράντα τέσσερις (144) συνολικά πειραματικές βολές με δυο (2) διαφορετικά κυνηγετικά όπλα, διαφορετικών κατασκευαστικών χαρακτηριστικών, αλλά ιδίου διαμετρήματος (12 Gauge) και με όλους τους δυνητικά πιθανούς συνδυασμούς βολών, όπλου, βαθμού στένωσης κάννης (τσοκ), γόμωση φυσιγγίων (βάρος, ΝΟ σκαγιών) και από αποστάσεις πυροβολισμού, 10, 18 και 25 μέτρα. Από τις μετρήσεις και την παρατήρηση όλων των πειραματικών βολών διαπιστώθηκε ότι από το σύνολο των σκαγιών κάθε βολής το 65% έως 80% αυτών κατανεμήθηκε ομοιόμορφα στο κέντρο του στόχου καταλαμβάνοντας ένα κύκλο, το εμβαδόν του οποίου για κάθε βολή υπολογίστηκε, ενώ μετρήθηκε και ο αριθμός των σκαγιών που περιέχονται σ΄ αυτόν. Με βάση τους συνταχθέντες πίνακες της ερευνητικής εργασίας, όταν διερευνάται μια επιφάνεια (στόχο), στην οποία έχουν προσκρούσει σκάγια κυνηγετικού όπλου και από την αυτοψία του χώρου ή από τα στοιχεία της δικογραφίας, προκύπτουν τα τεχνικά χαρακτηριστικά των πειστηρίων που σχετίζονται με το συμβάν (όπλα, φυσίγγια, κάλυκες, γόμωση φυσιγγίων κ.λπ.), τα οποία προσομοιάζουν με τα τεχνικά χαρακτηριστικά των όπλων και φυσιγγίων που χρησιμοποιήθηκαν στην ερευνητική εργασία, τότε παρέχεται η δυνατότητα στον εξεταστή - ερευνητή να προσδιορίζεται-εκτιμάται σε ποια απόσταση πυροβολισμού αντιστοιχεί κάθε σχετική μέτρηση.
Διερεύνηση του καρκίνου του προστάτη στον πληθυσμό της Θεσσαλίας με χρήση προηγμένων απεικονιστικών μεθόδων και ιστολογική συσχέτιση
Authors: Αγρότης Γεώργιος
Published: July 2024

Εισαγωγή –Στόχοι: Η διδακτορική διατριβή διερευνά την απεικονιστική προσέγγιση του καρκίνου του προστάτη, με επίκεντρο τη χρήση της πολυπαραμετρικής μαγνητικής τομογραφίας (mpMRI) σε συνδυασμό με διορθική υπερηχογραφική καθοδηγούμενη βιοψία (Fusion-guidedmpMRI-TRUS). Η εργασία έχει ως στόχο την αξιολόγηση της διαγνωστικής ακρίβειας αυτής της μεθόδου σε σύγκριση με τις παραδοσιακές συστηματικές βιοψίες, καθώς και τη βελτίωση των κλινικών αποτελεσμάτων μέσω της ακριβέστερης ανίχνευσης και κατηγοριοποίησης των καρκινικών εστιών. Μεθοδολογία: Η μεθοδολογία της μελέτης περιλαμβάνει την ανάλυση δεδομένων από 185 ασθενείς που υποβλήθηκαν σε mpMRIκαι βιοψία με συστηματική και fusion-guidedmpMRI-TRUS. Οι ασθενείς επιλέχθηκαν με βάση συγκεκριμένα κριτήρια(DRE, PSA, κλινική υποψία)και η στατιστική ανάλυση των δεδομένων πραγματοποιήθηκε με το SPSS έκδοση 28. Η μεθοδολογία περιλαμβάνει περιγραφή των διαδικασιών απεικόνισης και βιοψίας, καθώς και των παραμέτρων που χρησιμοποιήθηκαν για την αξιολόγηση των ευρημάτων. Αποτελέσματα: Συνολικά εντοπίστηκαν 81/185 (43,8%)περιπτώσεις θετικές για καρκίνο. 23/81 (28,4%) περιπτώσεις με μη κλινικά σημαντικόκαρκίνο του προστάτη-insPCaκαι 58/81 (71,6%) περιπτώσεις με κλινικά σημαντικό καρκίνο του προστάτη-csPCa. Υπήρξε στατιστικά σημαντική διαφορά στη συνολική ανίχνευση αδενοκαρκινωμάτων μεταξύ των μεθόδων (p = .035, δοκιμή McNemar). Επιπλέον, υπήρξε στατιστικά σημαντική διαφορά στην ανίχνευση insPCa μεταξύ των δύο μεθόδων (p = .004, δοκιμή McNemar). Η συστηματική βιοψία ανίχνευσε 13 ασθενείς με insPCa περισσότερους (14,4%) από τη στοχευμένη μέθοδο βιοψίας. Ωστόσο, δεν υπήρξε στατιστική διαφορά στο ποσοστό ανίχνευσης του csPCa μεταξύ των δύο μεθόδων (p = 1, δοκιμή McNemar). Όταν συνδυάστηκαν και οι δύο τεχνικές, εντοπίστηκαν περισσότερες περιπτώσεις csPCa. Συμπεράσματα: Η διατριβή καταλήγει στο συμπέρασμα ότι η πολυπαραμετρικήμαγνητική τομογραφία σε συνδυασμό με τη στοχευμένη διορθική υπερηχογραφική βιοψία αποτελεί μια αξιόπιστη και αποτελεσματική μέθοδο για την ανίχνευση του καρκίνου του προστάτη. Αυτή η προσέγγιση επιτρέπει την ανίχνευση κλινικά σημαντικών καρκίνων με μεγαλύτερη ακρίβεια, μειώνοντας παράλληλα τον αριθμό των περιττών βιοψιών. Επιπλέον, η mpMRI χρησιμοποιείται ως εργαλείο διαλογής των ασθενών πριν τη βιοψία, παρέχοντας σημαντικές πληροφορίες για τη λήψη κλινικών αποφάσεων. Η μελέτη προτείνει τη χρήση της mpMRIκαι της fusion-guidedmpMRI-TRUSμαζί με τη συστηματική βιοψία, ως πρότυπο για τη διάγνωση του καρκίνου του προστάτη, επισημαίνοντας τα πλεονεκτήματα αυτού του συνδυασμού σε σχέση με τις παραδοσιακές μεθόδους βιοψίας. Τέλος, η διατριβή τονίζει τη σημασία της συνεχούς εκπαίδευσης και εξειδίκευσης των ιατρών στη χρήση αυτών των τεχνολογιών για την επίτευξη βέλτιστων κλινικών αποτελεσμάτων.
Ozempic (semaglutide) - review of pharmacological properties, mechanism of action and clinical applications
Authors: Koman Anna Maria , Przygodzka Sabina , Gadżała Katarzyna , Janik Izabela , Pliszka Marzena , Palacz Karolina Alicja , Kułak Klaudia Brygida , Sztybór Izabela , Kuśmierska Martyna , Chamera-Cyrek Katarzyna
Published: July 2024

Introduction: Ozempic is a new generation antihyperglycemic drug used to treat type 2 diabetes in adults whose underlying disease is not sufficiently controlled with physical activity and diet, as well as for long-term weight control in people with excess body weight and comorbidities. The aim of this study is to explore and integrate the latest literature on the analysis of the pharmacology, mechanism of action and clinical applications of Ozempic.
Material and Methods of Research: A literature review focused on keywords related to the topic was performed using databases such as PubMed and Google Scholar.
Results: Ozempic effectively lowers blood glucose levels and supports weight loss in patients with type 2 diabetes and obesity. Clinical trials have demonstrated its superiority over other antidiabetic medications, with significant reductions in HbA1c and body weight. Patients receiving Ozempic experienced improved glycemic control and cardiovascular outcomes, with manageable side effects. Ongoing research suggests additional benefits in cardiovascular prevention and obesity management.
Conclusion: Ozempic (semaglutide) is a potent GLP-1 receptor agonist that effectively improves glycemic control and aids in weight reduction for patients with type 2 diabetes and obesity. Its practical administration, patient education, and regular monitoring are essential for optimal outcomes. Ongoing research and technological advancements, including the development of oral forms, promise to expand its applications and improve patient adherence, making Ozempic a versatile and valuable therapeutic option.
LA ORDEN DE MALTA Y AMÉRICA: PROSOPOGRAFÍA, CULTURA POLÍTICA Y ARBITRISMO FALLIDO (1665-1724)
Authors: Quirós Rosado Roberto
Published: July 2024

El vínculo entre la Orden de San Juan de Malta y América asistió, en la transición de los siglos XVII y XVIII, a una historia de éxitos y fracasos. Tras la venta de sus efímeras colonias en las islas de Barlovento a Francia en 1665, los caballeros de la Lengua de Castilla ejercieron reseñables servicios a la Monarquía de los Austrias en el Nuevo Mundo, a la vez que la memoria cronística y los gustos culturales siguieron teniendo a las Indias como un espacio central de su proyección. Asimismo, sus miembros en la España borbónica no dejaron de promover un retorno a América mediante el establecimiento de encomiendas en espacios de frontera para la lucha con los “infieles”.
LA GUERRA DEL PACÍFICO EN LOS PERIÓDICOS DE CHINA (1879-1883).
Authors: Soto Lara José Julián , Zhang Xiao
Published: July 2024

Se estudian las noticias que circularon en China sobre la Guerra del Pacífico. Los análisis de estructura, contenido y discurso practicados a los textos permiten concluir que los periódicos instituyeron imaginarios nacionales diferentes hacia Chile, Perú y Bolivia, destacando la organización política y poder militar del primer país en detrimento del segundo y el tercero.
First record of Coxiella sp. in Ornithodoros hasei parasitizing Rhogeessa tumida in México
Authors: Grostieta Estefania , Muñoz-Leal Sebastián , Zazueta-Islas Héctor M. , Solís-Cortés Marlene , Flores-Vázquez Fernanda , Ballados-González Gerardo G. , Colunga-Salas Pablo , Becker Ingegorg , Pech Canché Juan Manuel , Sánchez-Montes Sokani
Published: July 2024

Las garrapatas blandas representan un grupo desatendido de ectoparásitos asociadas con una amplia gama de vertebrados.  En México se han reportado 24 especies, la mayoría parasitando murciélagos.  Varias especies son vectores competentes de una amplia gama de microorganismos patógenos.  Por esta razón, el objetivo del presente trabajo fue identificar garrapatas asociadas con murciélagos de Tuxpan de Rodríguez Cano, Veracruz, México.  Los murciélagos fueron capturados usando redes de niebla y fueron inspeccionados visualmente para detectar la presencia de garrapatas.  Los ectoparásitos se identificaron morfológica y molecularmente con el uso del marcador mitocondrial 16SrDNA.  Adicionalmente, se realizó la detección molecular de varios patógenos bacterianos y protozoarios.  Se inspeccionaron 25 murciélagos de 9 especies.  Se recolectaron 7 larvas de garrapatas identificadas morfológicamente como Ornithodoros hasei de una hembra de murciélago amarillo de alas negras (Rhogeessa tumida).  La secuenciación del fragmento de 400 pb del gen 16S rDNA demostró una similitud del 96 % (373/388 pb) con O. hasei de Argentina y Brasil.  Adicionalmente, se confirmó la presencia de Coxiella sp.  Nuestros hallazgos proporcionan información relevante sobre la biología de O. hasei al identificar a R. tumida como un nuevo huésped, proporcionando el registro más nororiental para la distribución geográfica de esta garrapata en el Golfo de México y detectando la presencia de un nuevo huésped-endosimbionte en esta garrapata.
Helminths parasites of heteromyds rodents from semiarid regions of México
Authors: Falcón-Ordaz Jorge , Aquino-Camacho Mitzi F. , Ladrón de Guevara-Barcenas Karla , Fernández Jesús A.
Published: July 2024

Como parte de un proyecto en desarrollo para inventariar los helmintos parásitos de roedores heterómidos en México, se ha muestreado desde el año 2002 diversas localidades semiáridas del país, colectando los especímenes de los géneros Chaetodipus, Dipodomys, Liomys y Perognathus, obteniéndose un total de 19 helmintos (3 platelmintos y 16 nematodos).  Para el presente estudio se llevaron a cabo muestreos de roedores y sus parásitos durante los años 2007, 2008, 2015 y 2017, recolectándose 60 especímenes de la familia Heteromyidae (Chaetodipus sp., Dipodomys sp., D. merriami, D. phillipsii ornatus, Heteromys irroratus y Perognathus flavus) de diferentes regiones semiáridas localizadas en los estados de Chihuahua, Coahuila, Guanajuato, Hidalgo, Estado de México, Puebla y San Luis Potosí.  Derivado de la disección de los roedores recolectados se encontraron un total de 11 taxa de helmintos: 2 céstodos (Hymenolepis morfotipo 1 y morfotipo 2) y 9 nematodos (Capillaria cf. americana, Heteromyoxyuris otomii, Physaloptera sp., Protospirura dipodomis, Pterygodermatites dipodomis, Syphacia sp., Trichuris sp. T. elatoris y Vexillata sp.).  La presencia de parásitos con ciclo de vida directo (e. g., Hymenolepis sp. y Pt. dipodomis) nos indica que dentro de la alimentación de los roedores existe la presencia de un insecto.  Siete de los 11 helmintos encontrados en este trabajo coinciden con los registrados en estudios previos mostrando que la biota de las áreas semidesérticas de México cuenta con elementos de afinidad Neártica que la relacionan con el sur de los Estados Unidos de América.
Best practices for use of regional limb perfusion in a field setting
Authors: Tyma Jesse
Published: July 2024

Regional limb perfusion is an effective method of local antimicrobial delivery to the distal extremities of the horse. This technique is easy to perform and can augment the treatment of infectious orthopaedic injuries and wounds. Understanding the benefits and limitations of the procedure, recognising appropriate case selection and optimising the approach to regional limb perfusion will enable the field practitioner to incorporate this technique into their clinical approach and skillset, and implement it effectively.
Equine metabolic syndrome: part 2
Authors: Johnson Philip J
Published: July 2024

Obesity, insulin dysregulation and predisposition to endocrinopathic laminitis represent the major cornerstones of equine metabolic syndrome. This article summarises new information pertaining to the predispositions and pathophysiology of equine metabolic syndrome and presents some newly emergent and effective treatments for this important and common condition.
Effects of emerging SARS-CoV-2 on total and cause-specific maternal mortality: A natural experiment in Chile during the peak of the outbreak, 2020–2021
Authors: Enriquez Yordanis , Critto María Elena , Weinberg Ruth , de Janon Quevedo Lenin , Galleguillos Aliro , Koch Elard
Published: July 2024

This study estimated the effects of the COVID-19 pandemic on maternal mortality in Chile between 2020 and 2021. A natural experiment was conducted using official data on maternal deaths and live births (LBs) between 1997 and 2021. The effects of the SARS-CoV-2 outbreak were evaluated using interrupted time series (ITS) and an autoregressive integrated moving average (ARIMA) model to forecast the expected rates on MMR and 95% confidence intervals (95% CI). In Chile, following World Health Organization suggestions, maternal deaths aggravated by SARS-CoV-2 are assigned to code O98.5 (non-respiratory infectious indirect) accompanied by code U07.1 or U07.2, depending on confirmation of the presence or absence of the virus. ITS analysis revealed that the SARS-CoV-2 outbreak impacted the MMR due to indirect causes, with a greater increase in indirect nonrespiratory causes than respiratory causes. The ARIMA forecast was consistent with ITS, showing that the expected MMR for indirect causes (3.44 in 2020 and 1.55 in 2021) was substantially lower than the observed rates (9.65 in 2020 and 7.46/100.000 LBs in 2021). For nonrespiratory indirect causes, the observed values of the MMR for 2020 (8.77/100.000 LBs) and 2021 (7.46/100.000 LBs) were double the predicted values of 4.02 (95% CI: 0.44–7.61) and 3.83 (95% CI: -0.12–7.79), respectively. A lower effect was observed on direct obstetrical deaths. During 2020–2021, there was a rise in the MMR in Chile attributable to SARS-CoV-2. The pandemic contributed to an escalation in the MMR due to indirect causes, particularly nonrespiratory and infectious causes. MMR due to direct obstetric causes were less affected. This suggests that the pandemic disproportionately affected maternal health by exacerbating conditions unrelated to pregnancy, childbirth, or postpartum, more than those directly linked to obstetric complications.
Integrating health across the Sustainable Development Goals in the Eastern Mediterranean Region: Assessment of Voluntary National Reviews from 18 countries
Authors: Mabry Ruth M. , Doctor Henry V. , Khair Mina N. N. , Abdelgalil Maha , Rashidian Arash
Published: July 2024

Voluntary National Reviews are the formal mechanism for countries to report on progress and share lessons learned on SDG implementation. We assessed the Voluntary National Reviews submitted by countries in the WHO Eastern Mediterranean Region to note the reported progress on Sustainable Development Goal (SDG) implementation, the review preparation process and how health is positioned and framed to identify priorities for accelerating progress on the health-related SDGs. We extracted quantitative and qualitative data from 26 Voluntary National Reviews from 18 countries submitted during the period 2016 to January 2022. We focused on three areas: SDG implementation, the review preparation process and the positioning of health in the reviews. Three assessors conducted the data extraction based on the agreed framework according to their language of expertise (Arabic, English and French). One assessor supervised the whole process for consistency. If there was a doubt in interpretation, it was discussed and agreed among the assessors. Countries have established a mechanism for SDG implementation under high-level leadership, engaged in multistakeholder consultations, aligned and mainstreamed SDGs to national plans, and created a monitoring and review mechanism. Countries reported use of national participatory approach for the report preparation. The prioritization of both health and well-being (SDG3) and economic growth (SDG8) in the reports is unique compared to other regional and global assessments. Health was often framed around disease and health care provision without linkages to societal inequities and structural challenges. The reports indicated good progress in SDG implementation. Addressing upstream issues and the determinants of health requires the health sector to take a more strategic approach in advocating for health and well-being. Further research is needed to demonstrate how to address synergies and trade-offs of policy choices and identify the co-benefits of addressing health in the context of fiscal instability and widening inequities in the region.
A scoping review on the association between early childhood caries and life on land: The Sustainable Development Goal 15
Authors: Foláyan Morẹ́nikẹ́ Oluwátóyìn , Schroth Robert J. , Duangthip Duangporn , Al-Batayneh Ola B. , Virtanen Jorma I. , Sun Ivy Guofang , Arheiam Arheiam , Feldens Carlos A. , El Tantawi Maha
Published: July 2024

Background

The Sustainable Development Goal 15 (SDG15) deals with protecting, restoring, and promoting the sustainable use of terrestrial ecosystems, sustainably managing forests, halting and reversing land degradation, combating desertification and halting biodiversity loss. The purpose of this scoping review was to map the current evidence on the association between SDG 15 and Early Childhood Caries (ECC).

Methods

This scoping review was reported in accordance with the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) guidelines. Formal literature searches were conducted in PubMed, Web of Science, and Scopus in March 2023 using key search terms. Studies with the criteria (in English, with full text available, addressing component of life on land, focusing on dental caries in humans, with results that can be extrapolated to control ECC in children less than 6 years of age) were included. Retrieved papers were summarised and a conceptual framework developed regarding the postulated link between SDG15 and ECC.

Results

Two publications met the inclusion criteria. Both publications were ecological studies relating environmental findings to aggregated health data at the area level. One study concluded that the eco-hydrogeological environment was associated with human health, including caries. The other reported that excessive calcium was associated with the presence of compounds increasing groundwater acidity that had an impact on human health, including caries. The two ecological studies were linked to SDG 15.1. It is also plausible that SDG 15.2 and SDG 15.3 may reduce the risk for food insecurity, unemployment, gender inequality, zoonotic infections, conflict and migration; while SDG 15.4 may improve access to medicinal plants such as anticariogenic chewing sticks and reduction in the consumption of cariogenic diets.

Conclusions

There are currently no studies to support an association between ECC and SDG15 although there are multiple plausible pathways for such an association that can be explored. There is also the possibility of synergistic actions between the elements of soil, water and air in ways that differentially affect the risk of ECC. Studies on the direct link between the SDG15 and ECC are needed. These studies will require the use of innovative research approaches.
Memory systems modulate crosslinguistic influence on third language morphosyntactic acquisition
Authors: Xu Emily Shimeng , Matthews Stephen , Yip Virginia , Wong Patrick C. M.
Published: July 2024

Previous studies on crosslinguistic influence (CLI) on third language (L3) morphosyntactic acquisition have provided support for competing theories about the source(s) of CLI. The present study aimed to test if both L1 and L2 can be the source of CLI, and whether they influence L3 learning in similar or different ways. In particular, we aimed to add to our knowledge of the neural correlates of CLI by conducting an exploratory EEG study to investigate how L1 and L2 CLI affect L3 neural processing. Predictions based on the D/P model, which posited different memory systems sustaining L1 and L2, were tested. The findings confirmed both L1-sourced and L2-sourced facilitation on L3 morphosyntactic acquisition. Specifically, we suggest that L1-similarity showed a consolidating effect on L3 implicit knowledge and neurocognitive internalization, whereas L2-similarity contributed to enhanced L3 metalinguistic knowledge. This preliminary study is the first to investigate the neurocognitive mechanisms underlying CLI in L3 learning by natural language learners.
An image quality assessment index based on image features and keypoints for X-ray CT images
Authors: Maruyama Sho , Watanabe Haruyuki , Shimosegawa Masayuki
Published: July 2024

Optimization tasks in diagnostic radiological imaging require objective quantitative metrics that correlate with the subjective perception of observers. However, although one such metric, the structural similarity index (SSIM), is popular, it has limitations across various aspects in its application to medical images. In this study, we introduce a novel image quality evaluation approach based on keypoints and their associated unique image feature values, focusing on developing a framework to address the need for robustness and interpretability that are lacking in conventional methodologies. The proposed index quantifies and visualizes the distance between feature vectors associated with keypoints, which varies depending on changes in the image quality. This metric was validated on images with varying noise levels and resolution characteristics, and its applicability and effectiveness were examined by evaluating images subjected to various affine transformations. In the verification of X-ray computed tomography imaging using a head phantom, the distances between feature descriptors for each keypoint increased as the image quality degraded, exhibiting a strong correlation with the changes in the SSIM. Notably, the proposed index outperformed conventional full-reference metrics in terms of robustness to various transformations which are without changes in the image quality. Overall, the results suggested that image analysis performed using the proposed framework could effectively visualize the corresponding feature points, potentially harnessing lost feature information owing to changes in the image quality. These findings demonstrate the feasibility of applying the novel index to analyze changes in the image quality. This method may overcome limitations inherent in conventional evaluation methodologies and contribute to medical image analysis in the broader domain.
The inconsistency of p-curve: Testing its reliability using the power pose and HPA debates
Authors: Montoya R. Matthew , Kershaw Christine , Jurgens Christopher T.
Published: July 2024

Recent works have called into question whether p-curve can reliably assess the presence of "evidential value" within a set of studies. To examine an as-yet unexplored issue, we examined the method used to identify p-values for inclusion in a p-curve analysis. We developed iterated p-curve analysis (IPA), which calculates and p-curves every permutation for a set of reported p-values, and applied it to the data reported in several published p-curve analyses. Specifically, we investigated two phenomena for which p-curves have been used to evaluate the presence of evidential value: the power pose and the hypothalamic-pituitary-adrenal (HPA) reactivity debates. The iterated p-curve analyses revealed that the p-curve method fails to provide reliable estimates or reproducible conclusions. We conclude that p-curve should not be used to make conclusions regarding the presence or absence of evidence for a specific phenomenon.
Quercetin inhibits the epithelial-mesenchymal transition and reverses CDK4/6 inhibitor resistance in breast cancer by regulating circHIAT1/miR-19a-3p/CADM2 axis
Authors: Li Xiaogang , Niu Chao , Yi Guoqiang , Zhang Yuan , Jin Wendi , Zhang Zhiping , Zhang Wanfu , Li Bo
Published: July 2024

Breast cancer (BC) cells have a high risk of metastasis due to epithelial-mesenchymal transition (EMT). Palbociclib (CDK4/6 inhibitor) is an approved drug for BC treatment. However, the drug resistance and metastasis can impair the treatment outcome of Palbociclib. Understanding the mechanisms of EMT and Palbociclib drug resistance in BC is conducive to the formulation of novel therapeutic strategy. Here, we investigated the role of circHIAT1/miR-19a-3p/CADM2 axis in modulating EMT and Palbociclib resistance in BC. circHIAT1 and CADM2 were down-regulated in BC tissues and cell lines, and miR-19a-3p showed an up-regulation. circHIAT1 could interact with miR-19a-3p and suppress its activity, while miR-19a-3p functioned to negatively regulate CADM2. Forced over-expression of circHIAT1 could impaired the EMT status and migratory ability of BC cells, and this effect was inhibited by miR-19a-3p mimic. In addition, we also generated Palbociclib resistant BC cells, and showed that circHIAT1 and CADM2 were down-regulated in the resistant BC cells while miR-19a-3p showed an up-regulation. Forced circHIAT1 over-expression re-sensitized BC cells to Palbociclib treatment. Quercetin, a bioactive flavonoid, could suppressed the migration and invasion of BC cells, and re-sensitized BC cells to Palbociclib. The anti-cancer effect of quercetin could be attributed to its regulatory effect on circHIAT1/miR-19a-3p/CADM2 axis. In vivo tumorigenesis experiment further revealed that quercetin administration enhanced the anti-cancer effect of Palbociclib, an effect was dependent on the up-regulation of circHIAT1 by quercetin. In summary, this study identified quercetin as a potential anti-cancer compound to reverse Palbociclib resistance and impair EMT in BC cells by targeting circHIAT1/miR-19a-3p/CADM2 axis.
Visuomotor adaptation across the lifespan
Authors: Clayton Holly A. , Abbas Sahir , `t Hart Bernard Marius , Henriques Denise Y. P.
Published: July 2024

Being able to adapt our movements to changing circumstances allows people to maintain performance across a wide range of tasks throughout life, but it is unclear whether visuomotor learning abilities are fully developed in young children and, if so, whether they remain stable in the elderly. There is limited evidence of changes in motor adaptation ability throughout life, and the findings are inconsistent. Therefore, our goal was to compare visuomotor learning abilities throughout the lifespan. We used a shorter, gamified experimental task and collected data from participants in 5 age groups. Young children (M = 7 years), older children (M = 11 years), young adults (M = 20 years), adults (M = 40 years) and older adults (M = 67 years) adapted to a 45° visuomotor rotation in a centre-out reaching task. Across measures of rate of adaptation, extent of learning, rate of unlearning, generalization, and savings, we found that all groups performed similarly. That is, at least for short bouts of gamified learning, children and older adults perform just as well as young adults.
Assessment of perceived patient comfort and ease of bedpan handling by caregivers, a cross-sectional survey
Authors: Secher Cailleteau Pia , Cadon Lucie , Paille Cécile , Olivier Elise , Rulleau Thomas
Published: July 2024

Introduction

Since its creation in the 18th century, bedpan has remained more or less the same. Its unique material composition varies from one model to another, but its shape remains relatively similar. The environment is one of the four pillars of the nursing paradigm. It is therefore essential to question this device in the nursing discipline.

Aim

To assess perceived patient comfort and ease of bedpan handling by nurses and their assistants.

Method

A cross-sectional survey via an online questionnaire was conducted among nurses and nursing assistants, nursing students, and health executives using the bedpan for their patients to assess their feelings and their level of satisfaction. The questionnaire asks professionals about the ease of handling the bedpan and the patient’s perceived comfort.

Results

431 responses were obtained out of 3007 persons interviewed (14.3%). 83.0% believe that the cause of poor elimination by the patient is often or very often due to physical discomfort on the bedpan. 62.6% find the installation of the bedpan rather tough or very difficult. 59.2% find the removal of the bedpan rather tough or very difficult.

Discussion

Our study confirms our hypothesis and highlights a lack of comfort in the bedpan as perceived by professionals. This analysis is the first step in enabling the nurse researcher to support change in the transformation paradigm.
Endoscopic and Surgical Management of Bouveret Syndrome: Gastric Outlet Obstruction From an Impacted Gallstone
Authors: Manivannan Ahila , Khan Muhammad Zarrar , Simmer Stephen , Watson Andrew , Zuchelli Tobias , Elatrache Mazen
Published: July 2024

Impacted gallstones in the stomach and the duodenum lead to a rare presentation of gastric outlet obstruction known as Bouveret syndrome. Diagnosis and management is often challenging because of lack of streamlined protocol. However, when a diagnosis is made, there is an extensive toolkit available to endoscopists and surgeons to ensure favorable outcomes for the patient. In this article, we present a challenging case of Bouveret syndrome that required multidepartmental coordination and intervention.
Progress versus tradition – traditional craftsmanship and attempts at industrial tower clock production in the Czech lands in the 19th century
Authors: Knespl David
Published: July 2024

With the growing need for accurate timekeeping, the demand for clocks on public buildings increased in the 19th century. The only way to meet the demand, however, was to produce individual items by hand. Due to the conservative and protectionist influence of the clockmaker’s guilds and the absence of a specialised clockmaking education, technical innovations from abroad were slow to be adopted. Despite this, there are significant innovative watchmaking personalities, such as Josef Božek at the beginning and Václav Krečmer in the second half of the century. There were also several attempts at factory mass production of tower clocks, which, however, were not developed until the 1880s by the company of Ludvík Hainz.
A geopolitics of the diaspora of British engineers in South America in the first half of the 20th century: the cases of the Institution of Locomotive Engineers centre in Argentina
Authors: Rodríguez Ortiz Jorge Alonso
Published: July 2024

The circulation of British engineers in South America during the first half of the twentieth century is a barely explored phenomenon that should be studied in the basis of methodologies that articulate the different elements involved, with the aim of contributing to the history of technology and providing new interpretations regarding the development and decline of the South American railway system. Through the case of the Institution of Locomotive Engineers centre in Argentina, the phenomenon of the diaspora of technical knowledge and technology transmission is examined.
Escarafunchando os sentidos da docência: ofício e vocação
Authors: Fortunato Ivan , Araújo Osmar Hélio Alves , Medeiros Emerson Augusto de
Published: July 2024

Resumo: Este artigo, escrito na forma de um ensaio, tem como objetivo traçar uma discussão a respeito de um binômio particular ao magistério: ofício ou vocação. Nossa pergunta chave é: seria a docência um exercício de vocação, baseado no dom de ensinar e no apreço pelas pessoas? Por meio de três princípios da e para a docência, produzimos um diálogo articulado entre as premissas mais gerais a respeito do trabalho docente e as reflexões originadas da experiência cotidiana como professores formadores. Ao final, esperamos destacar a complexidade da profissão que é ofício e vocação.
Palavras-chave: Educação; Formação Docente; Ensino
Delving into meanings of teaching from three principles
Abstract: This paper, written as an essay, aims to outline a discussion about a particular binomial to the teaching profession: profession or calling. Our key question is: would teaching be an exercise of vocation, based on the gift of teaching and appreciation for people? Through three principles of and for teaching, we produced an articulated dialogue between the most general premises regarding teaching work and the reflections originated from the daily experience as teacher educators. In the end, we hope to highlight the complexity of the profession that is both profession and calling.
Keywords: Education; Teacher Education; Teaching
Profundizando en significados de la enseñanza desde tres principios
Resumen: Este artículo, escrito en forma de ensayo, tiene como objetivo esbozar una discusión sobre un binomio particular a la profesión docente: oficio o vocación. Nuestra pregunta clave es: ¿sería la docencia un ejercicio de vocación, basado en el don de la enseñanza y el aprecio por las personas? A través de tres principios de y para la docencia, producimos un diálogo articulado entre los presupuestos más generales en torno al trabajo docente y las reflexiones originadas desde la experiencia cotidiana como formadores de docentes. Al final, esperamos resaltar la complejidad de la profesión que es a la vez oficio y vocación.
Palabras clave: Educación; Formación de Profesores; Enseñanza
Data de registro: 29/06/2022
Data de aceite: 26/10/2022
Semel in vita: considerações sobre a brevidade do projeto fundacionalista cartesiano
Authors: Sousa Ana Cláudia Teodoro
Published: July 2024

Resumo: O objetivo desse trabalho é explorar a perenidade e o significado da expressão semel in vita para a filosofia de Descartes. Por meio de uma análise minuciosa de todas as ocorrências dessa formulação dentro do corpus cartesiano, busca-se evidenciar que semel in vita é um recurso retórico relevante que está vinculado ao momento decisivo da filosofia cartesiana de realizar uma reestruturação do conhecimento a partir da investigação radical e preliminar sobre o escopo do entendimento humano. É concluído, dessa forma, que a estratégia cartesiana de reformulação científica, desde a sua juventude, depende de um inquérito sobre o entendimento puro, mas que este inquérito deve ser realizado e acabado, já que fornece os recursos para seguir em investigações ulteriores.
Palavras-Chave: Descartes; Conhecimento; Metafísica; Fundacionalismo
Semel in vita: considerations on the brevity of the Cartesian foundational project
Abstract: The objective of this work is to explore the perenniality and meaning of the expression semel in vita for the philosophy of Descartes. Through a carefully analysis of all occurrences of this formulation within the Cartesian corpus, this work seeks to show that semel in vita is a relevant rhetorical resource that is linked to the decisive moment of Cartesian philosophy to carry out a restructuring of knowledge starting from the radical and preliminary investigation on the scope of human understanding. It is thus concluded that the Cartesian strategy of scientific reformulation, from its youth, depends on an inquiry into pure understanding, but that this inquiry must be carried out and finished, since it provides the resources to follow in further investigations.
Key-words: Descartes; Knowledge; Metaphysics; Foundationalism
Semel in vita: considérations sur la brièveté du projet fondamentaliste cartésien
Résumé: Le but de ce travail est d’explorer la pérennité et la signification de l’expression semel in vita pour la philosophie de Descartes. Au moyen d’une analyse approfondie de toutes les occurrences de cette formulation dans le corpus cartésien, on cherche à mettre en évidence que semel in vita est une ressource rhétorique importante qui est liée au moment décisif de la philosophie cartésienne de réaliser une restructuration de la connaissance à partir de la recherche radicale et préliminaire sur l’étendue de la compréhension humaine. Il est donc conclu que la stratégie cartésienne de refonte scientifique, dès son plus jeune âge, dépend d’une enquête sur l’entendement pure, mais que cette enquête doit être menée et achevée, car elle fournit des ressources pour poursuivre des recherches ultérieures.
Mots-clés: Descartes; Connaissance; Métaphysique; Fondationnalisme
Data de registro: 23/12/2023
Data de aceite: 20/09/2023
Entrevista com Prof. Dr. Rodrigo Duarte
Authors: Silva Rafael Cordeiro , Gomide Ana Paula de Ávila , Dias João Paulo Andrade , Saldanha Victor Hugo de Oliveira Saldanha
Published: July 2024

Entrevista realizada em outubro de 2023 por Rafael Cordeiro Silva, Ana Paula de Ávila Gomide, João Paulo Andrade Dias, Victor Hugo de Oliveira Saldanha e concedida a Educação e Filosofia para publicação no v. 37, n. 81, p. 1727-1740, set./dez. 2023, como parte integrante do Dossiê Teoria Crítica 100 Anos organizado por Prof. Dr. Rafael Cordeiro Silva, Prof. Drª. Ana Paula de Ávila Gomide e Prof. Dr. Sertório de Amorim e Silva Neto, e também publicado nesta mesma edição.
Cidades e a Transição Demo-Climática no Brasil
Authors: Barbieri Alisson Flávio
Published: July 2024

O artigo propõe uma reflexão sobre os desafios para o planejamento e as políticas públicas em termos da adaptação das cidades brasileiras à dinâmica futura da transição climática e das transições populacionais (demográfica, epidemiológica, urbana e de mobilidade). A relação recursiva entre tais transições será determinante para definir como os Sistemas Socioambientais Urbanos, que incluem as suas populações em distintos tamanhos, densidades, distribuições espaciais intraurbana e composições, e as características ambientais, socioeconômicas, morfológicas e funcionais das cidades, terão que se adaptar aos riscos e desastres nas próximas décadas. Inicialmente, o artigo discute as principais características das transições populacionais e climática, as suas relações com o processo de modernização, e o desafio que representam para a adaptação dos Sistemas Socioambientais Urbanos. É discutido, em seguida, o conceito de Transição Demo-climática como o reconhecimento da natureza endógena da relação entre as transições populacionais e as mudanças ambientais globais, especificamente as mudanças climáticas. Por fim, é proposto um modelo conceitual de adaptação de Sistemas Socioambientais Urbanos aos desafios da Transição Demo-climática, tendo como eixo os aumentos de capacidade adaptativa e resiliência urbanas, e a construção de capacidade de planejamento e políticas públicas de curto, médio e longo prazos. Nesse contexto, o planejamento, como a ponte entre um processo político (Policy) e o conhecimento científico associado aos saberes locais, é um instrumento fundamental para potencializar a resiliência e capacidade adaptativa dos Sistemas Socioambientais Urbanos como resposta à emergência climática.
Dinâmica Espaço-Temporal do Uso das Terras em Mato Grosso do Sul Entre 1988 a 2018 e Pagamentos por Serviços Ecossistêmicos
Authors: Farinha Maycon Jorge Ulisses Saraiva , Berezuk André Geraldo , Bernardo Luciana Virginia Mario , Soares Filho Adelsom
Published: July 2024

As ações do homem na natureza são uma relação antiga que possibilita, dentre algumas características, a mudança no uso da terra. Uma possibilidade de estudo destas mudanças está na classificação destes usos e suas transformações no decorrer dos anos, de modo a possibilitar conhecer a relação das pessoas com a natureza em uma determinada localidade. Neste contexto, a pesquisa abordou o Estado de Mato Grosso do Sul, com objetivo de investigar a dinâmica e o espaço temporal do uso das terras de suas mesorregiões, e a implementação de ações públicas e privadas de políticas ambientais desenvolvidas nos municípios, visando o escopo dos serviços ecossistêmicos. Para isso, foi utilizado o modelo Shift-Share, para identificar as transformações no uso da terra, no período de 1988 a 2018, os dados foram extraídos do MapBiomas. Além disso, a partir do que preconiza o Código Florestal para a conservação de áreas em propriedades rurais e as Unidades de Conservação criadas, estimou-se o Valor da Conservação via Políticas Públicas por município do estado. No período de análise, pode-se perceber que, entre 1988 e 2018, ocorreram mudanças no uso das terras em todas as mesorregiões do estado. Cada mesorregião tem suas características singulares para a substituição do uso das terras, mas, de forma geral, pode-se perceber que a vegetação natural tem perdido área para outros usos, sendo o principal destino o uso agropecuário. Foi observado também, como as políticas públicas ambientais, tem auxiliado a conservação das áreas, em Mato Grosso do Sul.
Parenting Styles and Gadget Use: Examining hIntensity and Negative Impacts on Early Childhood Development in Bima City
Authors: Muliati Meli , Hendra Hendra , Ruslan Ruslan
Published: July 2024

This study explores the influence of different parenting styles democratic, authoritarian, and permissive on the intensity of gadget use and its negative impacts on children aged 1-8 years in Bima City. Utilizing a mixed-methods approach, the research design included literature review, hypothesis formulation, data collection via online questionnaires, and data analysis. Quantitative data were analyzed using regression techniques, and qualitative data provided contextual depth. The findings reveal significant differences in gadget use intensity and associated negative outcomes, including reduced social skills and hearing problems, depending on parenting style. Democratic and authoritarian parenting were linked to higher gadget use, while permissive parenting exhibited a wide range of use patterns, from high usage to complete abstention. The study underscores the importance of effective parental monitoring and engagement to manage children's screen time and mitigate adverse effects. Limitations include a localized sample and reliance on self-reported data, suggesting the need for further research in diverse populations. These findings have important implications for parenting strategies and public health policies, emphasizing the need for targeted interventions to educate parents on managing children’s digital habits and promoting healthy development. Future research should further investigate these relationships and develop comprehensive support strategies for parents.
Development of a Hierarchy of Augmentative and Alternative Communication Resources and Situation Switching User Interface for Location and Situation-Based AAC
Authors: Seo Jiwoo , Ryu Se Hui , Hong Ki-Hyung , Yeon Seok Jeong , Chae Soojung , Lee Heeyeon ,   Korean Society of Augmentative and Alternative Communication
Published: July 2024

Background and Objectives: For people who have difficulties in language, locationbased Augmentative and Alternative Communication (AAC) mobile applications recommend AAC symbols based on their location to assist communication in daily life. Using AAC symbols available at a specific location with smart devices having small screens requires additional actions like swiping, which can be burden for [This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HJ21C0007). This research extends the poster presentation of ‘An AAC Board Hierarchy and User Interface for Communication Situation Switching in Location-Based AAC’ in ‘The 3rd East Asian Regional Conference on Augmentative and Alternative Communication: AAC Beyond Pandemic’ of Korean Society of Augmentative and Alternative Communication (KSAAC). Correspondence to Ki-Hyung Hong, Ph.D., Department of Service Design Engineering, Sungshin Women’s University, Seoul, Korea, e-mail: khhong@sungshin.ac.kr, tel: + 82 2 920 7525] AAC users. This study aims to make it easier for AAC users to explore symbols and improve efficiency of facilitation by reusing AAC resources. Method: We define AAC situation boards as collections of AAC symbols specifically needed for certain communication situations. Group AAC boards, on the other hand, are collections of AAC symbols that belong to the same categories. We designed a hierarchy to allow these situation and group AAC boards to be included as sub-boards in general and location AAC boards. We also developed a user interface that allows facilitators to manage AAC resources based on the hierarchy. The interface makes it easy for AAC users to select appropriate AAC symbols for the current situation through a situation-based symbol circulation and switching method. Result & Conclusion: We enhanced and expanded location and situation-based AAC mobile applications by utilizing a hierarchy of AAC resources and integrating a user interface for efficient management and utilization of these resources. To assess its usability, we conducted a user evaluation involving 44 facilitators. The results of the evaluation indicate that the location and situation-based AAC mobile application, with its ability to switch situations based on the AAC resource hierarchy, received high ratings in terms of satisfaction, convenience, and stability.
Examining the swelling potential of cohesive soils with high plasticity according to their index properties using GIS
Authors: Kalkan Murat
Published: July 2024

As the value ranges presented in the literature with tables and graphs that feature soil index properties related to the soil swelling potential are intertwined, their interpretation may pose certain challenges. In this study, the spatial distribution maps of soil swelling potential were created using soil index data obtained from this research, and those values of ranges from the swelling potential of the study area were assessed by combining all maps, resulting in a single comprehensive map and new limit ranges in the high plasticity cohesive soils. Soils in the study area were evaluated according to the newly determined limit value ranges. The findings show that the high plasticity cohesive soils in the region should have swelling potential in all parameters of the new limit value ranges to show swelling potential. The limit values for high plasticity cohesive soils to demonstrate a high swelling potential are: % natural water content <18, % passing through #200 sieve >90, liquid limit >65, plasticity index >21, swelling pressure >240 kPa, and % swelling percentage >6.