bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of adverse drug reactions on the outcomes of tuberculosis treatment
Authors: Sant´Anna Flávia M. , Araújo-Pereira Mariana , Schmaltz Carolina A. S. , Arriaga María B. , Andrade Bruno B. , Rolla Valeria C.
Published: February 2023

Background

Adverse drug reactions (ADR) challenge successful anti-tuberculosis treatment (ATT). The aim of this study was to evaluate the impact of ATT-associated ADR and related factors on ATT outcomes.

Methods

A prospective cohort study of persons with tuberculosis (TB) at a referral center in Rio de Janeiro, Brazil, from 2010 to 2016. Baseline information: race, sex, schooling, economic status, tobacco, drugs and alcohol abuse, HIV-infection status and comorbidities were captured during TB screening and diagnosis. Laboratory exams were performed to confirm TB diagnosis and monitor ADRs, favorable (cure and treatment completion) and unfavorable (death, loss to follow up and failure) outcomes were prospectively captured. The Kaplan-Meier curve was used to estimate the probability of ADR-free time. A logistic regression analysis (backward elimination) was performed to identify independent associations with unfavorable outcomes.

Results

550 patients were enrolled, 35.1% were people living with HIV (PLHIV) and ADR occurred in 78.6% of all participants. Smoking (OR: 2.32; 95% CI:1.34–3.99) and illicit-drug use (OR:2.02; 95% CI:1.15–3.55) were independent risk factors for unfavorable outcomes. In PLHIV, alcohol abuse and previous ART use were associated with unfavorable outcomes. In contrast, ADR increased the odds of favorable outcomes in the overall population. PLHIV more frequently experienced grade 3/4-ADR (18.36%), especially “liver and biliary system disorders”. Lower CD4 counts (<100 cells/uL) were associated with hepatotoxicity (p = 0.03). ART-naïve participants presented a higher incidence of ADR in comparison with ART-experienced patients.

Conclusion

Substance use was associated with unfavorable outcomes, highlighting the need for better strategies to reduce this habit. In contrast, ADRs were associated with favorable outcomes. Attention to the occurrence of ADR in PLHIV is essential, especially regarding hepatotoxicity in those with high immunosuppression.
A differential correction based shadow removal method for real-time monitoring
Authors: Liu Sheng , Chen Meng , Li Zhiheng , Liu Jingxian , He Menglong
Published: February 2023

Shadow removal is an important issue in the field of motion object surveillance and automatic control. Although many works are concentrated on this issue, the diverse and similar motion patterns between shadows and objects still severely affect the removal performance. Constrained by the computational efficiency in real-time monitoring, the pixel feature based methods are still the main shadow removal methods in practice. Following this idea, this paper proposes a novel and simple shadow removal method based on a differential correction calculation between the pixel values of Red, Green and Blue channels. Specifically, considering the fact that shadows are formed because of the occlusion of light by objects, all the reflected light will be attenuated. Hence there will be a similar weakening trends in all Red, Green and Blue channels of the shadow areas, but not in the object areas. These trends can be caught by differential correction calculation and distinguish the shadow areas from object areas. Based on this feature, our shadow removal method is designed. Experiment results verify that, compared with other state-of-the-art shadow removal methods, our method improves the average of object and shadow detection accuracies by at least 10% in most of the cases.
Can mask mandates boost nature-based tourism? The role of escapism and travel anxiety
Authors: Paredes Mario R. , Apaolaza Vanessa , Hartmann Patrick , Marcos Aitor , García-Merino Jose Domingo
Published: February 2023

Tourism in a post-pandemic era will likely be oriented toward nature because contact with nature has restorative health benefits. The purpose of this study was to analyze the antecedents of tourists’ intentions to visit nature-based resorts during a pandemic. A nationally representative sample of the Spanish population (n = 500) was recruited by an online commercial panel to test and empirically validate the proposed conceptual framework. The findings confirmed a direct relationship between negative perceptions of wearing face masks during the COVID-19 pandemic and tourists’ intentions to visit nature-based resorts. The relationship between the perceived negative effects of wearing face masks and the intention to visit nature-based resorts was positively mediated by the need for escapism. This impact was less pronounced for anxious travelers, as shown by results corroborating the moderating effect of travel anxiety. The findings of this study contribute to research on tourism crises and provide future insights into the recovery of the industry during COVID-19.
Atrial fibrillation in UK South Asian hospitalized ischemic stroke patients: The BRAINS study
Authors: Aurelius Taylor , Ken-Dror Gie , Sharma Sapna D. , Amlani Sageet , Gunathilagan Gunaratnam , Cohen David L. , Rajkumar Chakravarthi , Maguire Stuart , Ispoglou Sissi , Balogun Ibrahim , Parry Anthea , Sekaran Lakshmanan , Syed Hafiz , Lawrence Enas , Singh Ravneeta , Hassan Ahamad , Wharton Chris , Javaid Khalid , Goorah Neetish , Carr Peter , Abdus Sami Eman , Sharma Pankaj
Published: February 2023

Introduction

South Asian diaspora comprise one of the largest ethnic minority groups in the world yet data about atrial fibrillation (AF) in this demographic is understudied. Our aim is to identify differences in AF prevalence and treatment between South Asians and white British stroke patients.

Method

The UK arm of a prospective ongoing large international repository on stroke was analysed. Ethnic differences in AF prevalence and management in those with ischemic stroke were analysed.

Results

Of the 3515 individuals recruited with ischemic stroke, 1482 (men: 972, women: 510) were South Asian and 2033 (men:1141, women:892) of white British ethnicity. AF was present in 462 white British and 193 South Asians stroke patients, with South Asians displaying a lower prevalence of AF (South Asians: 13.0% vs white British 22.7%, P<0.001). Despite adjustment for traditional AF risk factors, South Asians had a significantly lower OR of AF compared to white British stroke patients (OR: 0.40, 95%CI: 0.33:0.49, P<0.001). Among confirmed AF cases, 31.8% of South Asians and 41.4% of white British were untreated at admission (P = 0.02). Antiplatelet treatment was significantly higher among South Asians at both admission (South Asian: 47.4% vs. white British: 29.9%, P<0.001) and discharge (South Asian: 49.5% vs. white British: 34.7%, P = 0.001), although anticoagulation treatment was similar across both ethnic groups at admission (South Asian: 28.5% vs white British: 28.1%, P = 0.93), and discharge (South Asian: 45.1% vs white British: 43.1%, P = 0.64).

Conclusion

Stroke patients of South Asian descent are at significantly lower risk of AF but more likely to be on antiplatelet treatment compared to their white British counterparts.
The effects of microbiome-targeted therapy on cognitive impairment and postoperative cognitive dysfunction—A systematic review
Authors: Sugita Saiko , Tahir Peggy , Kinjo Sakura
Published: February 2023

Background

The gut-brain axis involves bidirectional communication between the gut-microbiota and central nervous system. This study aimed to investigate whether probiotics and/or prebiotics, known as Microbiome-targeted Therapies (MTTs), improve cognition and prevent postoperative cognitive dysfunction (POCD).

Methods

Relevant animal and human studies were identified using a systematic database search (PubMed, EMBASE, Cochrane Library, and Web of Science), focusing on the effects of MTTs on inflammation, perioperative and non-perioperative cognitive impairment. Screening and data extraction were conducted by two independent reviewers. The Risk of bias was assessed using the SYRCLE’s risk of bias tool for animal studies. The revised Cochrane risk of bias tool (RoB 2) was used for human studies.

Results

A total of 24 articles were selected; 16 of these involved animal studies, and 8 described studies in humans. In these papers, the use of MTTs consistently resulted in decreased inflammation in perioperative and non-perioperative settings. Out of 16 animal studies, 5 studies (2 associated with delirium and 3 studies related to POCD) were conducted in a perioperative setting. MTTs improved perioperative cognitive behavior and reduced inflammation in all 5 animal studies. Eleven animal studies were conducted in a non-perioperative setting. In all of these studies, MTTs showed improvement in learning and memory function. MTTs showed a positive effect on levels of pro-inflammatory cytokines and biomarkers related to cognitive function. Among the 8 human studies, only one study examined the effects of perioperative MTTs on cognitive function. This study showed a reduced incidence of POCD along with improved cognitive function. Of the remaining 7 studies, 6 suggested that MTTs improved behavioral test results and cognition in non-perioperative environments. One study failed to show any significant differences in memory, biomarkers of inflammation, or oxidative factors.

Conclusion

In the studies we examined, most showed that MTTs decrease inflammation by down-regulating inflammatory cytokines and oxidative stress in both perioperative and non-perioperative settings. In general, MTTs also seem to have a positive effect on cognition through neural, immune, endocrine, and metabolic pathways. However, these effects have not yet resulted in a consensus regarding preventative strategies or treatments. Based on these current research results, MTTs could be a potential new preventative strategy for cognitive impairment after surgery.
Pretreatment with antibiotics is associated with reduced therapeutic response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma
Authors: Maesaka Kazuki , Sakamori Ryotaro , Yamada Ryoko , Doi Akira , Tahata Yuki , Ohkawa Kazuyoshi , Oshita Masahide , Miyazaki Masanori , Yakushijin Takayuki , Nozaki Yasutoshi , Matsumoto Kengo , Tanaka Satoshi , Kaneko Akira , Iio Sadaharu , Nawa Takatoshi , Yamada Yukinori , Morishita Naoki , Usui Takeo , Hiramatsu Naoki , Doi Yoshinori , Sakakibara Mitsuru , Imanaka Kazuho , Yoshida Yuichi , Kodama Takahiro , Hikita Hayato , Tatsumi Tomohide , Takehara Tetsuo
Published: February 2023

Aim

Alterations in microbial composition of gut microbiota due to antibiotics (ATB) may lead to resistance to immune checkpoint inhibitors (ICIs). This study aimed to assess the impact of ATB use on therapeutic response in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab.

Methods

This study retrospectively analyzed 105 patients with HCC treated with atezolizumab plus bevacizumab as a primary systemic therapy from prospectively-registered, multicenter, cohorts. Nineteen patients who received prior ATB were included in the ATB (+) group; 86 patients who did not receive prior ATB were included in the ATB (-) group. The therapeutic outcomes were compared between the two groups.

Results

Most of the patients’ baseline characteristics were not significantly different between the two groups. The objective response rates according to the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) (30.1% vs. 11.1%; p = 0.143) and modified RECIST (mRECIST) (44.6% vs. 27.8%; p = 0.190) were not significantly different between the ATB (-) and ATB (+) groups. The disease control rates were higher in the ATB (-) group than in the ATB (+) group according to RECIST v1.1 (74.7% vs. 44.4%; p = 0.012) and mRECIST (78.3% vs. 50.0%; p = 0.020). Prior ATB use was found to be independently associated with radiological progressive disease of the first therapeutic assessment. The median progression-free survival according to RECIST v1.1 (9.1 months vs. 3.0 months; p = 0.049) and mRECIST (9.1 months vs. 3.0 months; p = 0.036), and overall survival (not reached vs. 11.4 months; p = 0.015) were longer in the ATB (-) group than in the ATB (+) group.

Conclusions

Prior ATB use was associated with reduced therapeutic responses in patients with HCC receiving atezolizumab plus bevacizumab.
Hsa-miR-22-3p inhibits liver cancer cell EMT and cell migration/ invasion by indirectly regulating SPRY2
Authors: Cui Shuaishuai , Chen Yuanyuan , Guo Yunfei , Wang Xing , Chen Dahu
Published: February 2023

The general mechanism for microRNAs to play biological function is through their inhibition on the expression of their target genes. In cancer, microRNAs may accelerate cell senescence, block angiogenesis, decrease energy supplies, repress tumor cell cycle and promote apoptosis to function as the tumor repressors. On the other hand, microRNAs can modulate tumor suppressor molecules to activate oncogene relevant signaling pathway to initiate tumorigenesis and promote tumor progression. By targeting different genes, miR-22 can function as either a tumor suppressor or a tumor promoter in different types of cancer. In liver cancer, miR-22 mainly functions as a tumor suppressor via its regulation on different genes. In this study, we demonstrated that miR-22 indirectly regulates SPRY2 by inhibiting CBL, an E3 ligase for SPRY2 that has been confirmed. As one of the modulators of the MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated kinase) signaling pathway, SPRY2 plays important roles in many developmental and physiological processes, and its deregulation has been reported in different types of cancer and shown to affect cancer development, progression, and metastasis. By inhibiting the expression of CBL, which stabilizes SPRY2, miR-22 indirectly upregulates SPRY2, thereby suppressing the epithelial-mesenchymal transition (EMT), cell migration, and invasion and decreasing the expression of liver cancer stem cell (CSC) marker genes. The inhibitory effects of miR-22 on EMT, cell migration, and invasion can be blocked by the knockdown of SPRY2 expression in miR-22 overexpressing cells. Additionally, we demonstrated that miR-22 expression inhibits the ERK signaling pathway and that this effect is due to its upregulation of SPRY2. Overall, our study revealed a novel miR-22-3p/CBL/SPRY2/ERK axis that plays an important role in EMT, cell migration, and invasion of liver cancer cells.
Does the presence of health insurance and health facilities improve access to healthcare for major morbidities among Indigenous communities and older widows in India? Evidence from India Human Development Surveys I and II
Authors: George Mathew Sunil , Niyosenga Theo , Mohanty Itismita
Published: February 2023

In this paper, we examine whether access to treatment for major morbidity conditions is determined by the social class of the person who needs treatment. Secondly, we assess whether health insurance coverage and the presence of a PHC have any significant impact on the utilisation of health services, either public or private, for treatment and, more importantly, whether the presence of health insurance and PHC modify the treatment use behaviour for the two excluded communities of interest namely Indigenous communities and older widows using data from two rounds (2005 and 2012) of the nationally representative India Human Development Survey (IHDS). We estimated a multilevel mixed effects model with treatment for major morbidity as the outcome variable and social groups, older widows, the presence of a PHC and the survey wave as the main explanatory variables. The results confirmed access to treatment for major morbidity was affected by social class with Indigenous communities and older widows less likely to access treatment. Health insurance coverage did not have an effect that was large enough to induce a positive change in the likelihood of accessing treatment. The presence of a functional PHC increased the likelihood of treatment for all social groups except Indigenous communities. This is not surprising as Indigenous communities generally live in locations where the terrain is more challenging and decentralised healthcare up to the PHC might not work as effectively as it does for others. The social class to which one belongs has a significant impact on the ability of a person to access healthcare. Efforts to address inequity needs to take this into account and design interventions that are decentralised and planned with the involvement of local communities to be effective. Merely addressing one or two barriers to access in an isolated fashion will not lead to equitable access.
Amadou Hampâté Bâ: Un voyage à travers la tradition
Authors: Narbona Inmaculada Díaz , Boisson Cristina Boidard
Published: February 2023

The importance of tradition is fundamental in Amadou Hampâté Bâ's works. In his Memories, the prominent traditionalist Malian writer addresses questions of 'Tradition' in the African context. These questions are a rich journey into the history of the African continent
during the twentieth century, from colonization to the Independences.
La música de acompañamiento
Authors: Payri Blas
Published: February 2023

Definimos varios tipos de obras audiovisuales en torno a la danza (film de danza comercial, videodanza, videoclip) para analizar la naturaleza y la función de la música en cada caso. Proponemos el concepto de música de acompañamiento, que es una herencia de la música de foso del teatro musical y la danza escénica. Dicha música tiene unas características melódico-rítmicas que la hacen bailable o cantable, una estructura propia, y se realiza en preproducción para que genere y acompañe la acción de la danza y el canto durante el rodaje. Se diferencia de la música cinematográfica incidental que se ajusta a la estructura del montaje en la postproducción, pero no lo genera.
Concluimos que la música de acompañamiento se diferencia de la música incidental porque es oída por los personajes y genera la acción de la danza. Es una música que pertenece a la diégesis de la danza/coreografía, pero los músicos que la generan son ajenos a la diégesis de la danza. Independientemente de que el acompañamiento tenga una justificación diegética o no en el film musical, su mezcla y espacialización es envolvente y absoluta como una música de espectáculo, y rompe con el realismo de espacialización de la música diegética.
El maestro Suñé, un caso paradigmático como músico y director en el acompañamiento musical cinematográfico de la tercera déca da del s. XX en Barcelona
Authors: Gil Zulueta Jorge
Published: February 2023

Esta publicación presenta una inicial reconstrucción de la trayectoria de uno de esos músicos «anónimos» que se dedicaban al acompañamiento musical de las películas en los años veinte del pasado siglo. José Suñé Tomás aparece referenciado en los medios de prensa y revistas cinematográficas de la época como «el maestro Suñé» junto a la orquestina de su propio apellido. Pero en este caso no es un nombre más entre los dispersos en las agendas culturales, sino que sobresale en determinados reportajes la distinción de su trabajo musical en torno a un cine que aún no conocía lo que hoy universalizamos como banda sonora musical.
Partiendo de los escasos datos biográficos que hasta el momento se tienen, se esboza a través de un análisis hemerográfico el perfil formativo del maestro, la actividad que realizó la orquestina Suñé en los cines Kursaal y Capitol entre 1923 y 1928, los acompañamientos musicales de los diferentes estrenos de las producciones cinematográficas más importantes de mediados de los años veinte, así como las pocas partituras localizadas en su producción compositiva o como arreglista, por lo que podemos considerarlo como un caso paradigmático del hecho musical del cine «mudo» español.
KESIAPAN NILAI TRADISIONAL MASYARAKAT SUNDA DALAM REVOLUSI INDUSTRI 4.0 MENUJU SOCIETY 5.0
Authors: Pratika Sindi , Megawati Annisa Sriayuning , Maulana Ilham Rizkia
Published: February 2023

The industrial revolution 4.0 has great potential benefits for human life but still cannot be utilized optimally. On the other hand, the concept of society 5.0 focuses on a human-centered and technology-based society already developed partially. The transition from the industrial revolution 4.0 to society 5.0 certainly affected the lives of Indonesian society, including Sundanese society. According to modern values, the values of Sundanese traditional that is needed to be maintained on the transition from the industrial revolution 4.0 to society 5.0 is interesting to explore. This research aims to understand the existence of traditional Sundanese values, identify the inclusion of traditional Sundanese values between young and old in their interaction with modern values, and analyze the repositioning of Sundanese people in synergizing modern values to traditional values from industrial revolution 4.0 to society 5.0. The study is secondary research with a literature review from 23 with relevant keyword-based selected journals. The result is that the modern value of the industrial revolution 4.0 embraced by the younger generation does not conform to the traditional Sundanese values held by the older generation thus leading to the inclusion of different traditional Sundanese values and threatening the existence of traditional Sundanese values. The result also indicates that the transitioning from industrial revolution 4.0 to society 5.0 needs repositioning of Sundanese traditional values that able to synergize or collaborate with modern values towards society 5.0.
ETHICAL IMPLICATION OF GOD CONCEPT IN JAVANESE PRAYERS
Authors: Sartini Sartini
Published: February 2023

Penelitian ini didasari oleh fenomena ketidakpahaman maksud ritual  dan doa yang sering menimbulkan klaim kekafiran sehingga menjadi pemicu konflik  di masyarakat. Kebudayaan Jawa yang penuh ritual dan variasi doa menjadi salah satu objek yang menarik untuk dikaji. Penelitian ini bertujuan mengeksplorasi pengertian doa, macam doa Jawa, konsep Tuhan di dalam doa Jawa, dan implikasi etik dari doa.  Penelitian ini merupakan penelitian pustaka mengenai konsep yang ada di masyarakat. Untuk mendapatkan hasil penelitian dilakukan pengumpulan sumber bacaan, pembacaan referensi, deskripsi, klasifikasi, analisis dan penyimpulan. Hasil penelitian menunjukkan bahwa doa merupakan ucapan atau ungkapan keinginan berupa pernyataan eksistensi, pemujaan, permohonan, kepasrahan, kesyukuran dan ungkapan terima kasih  kepada Tuhan atau entitas Supranatural. Doa Jawa dibagi dua yaitu doa Slametan dan  mantra.  Kebanyakan doa Slametan dan doa mantra yang bersifat baik,  mengandung unsur nama Tuhan, sebagian lain mengandung unsur Nabi, sahabat Nabi, wali, dan nenek moyang. Hal ini bermakna keyakinan atas kekuasaan Tuhan dan penghormatan kepada para pihak yang berperan dalam hidup. Doa mantra yang cenderung bersifat negatif terindikasi tidak menyebut nama Tuhan dan tokoh kehidupan yang dihormati. Doa Slametan lebih bersifat baik dan komunal, bermuatan etik, mengarahkan pada laku baik. Doa Slametan juga berisi harapan untuk kebaikan diri pendoa dan semua manusia.
Complementing The Access Theory by Collaborative Approach in Indonesia Social Forestry Context
Authors: Rachmawan Dicky , Seda Francisia Saveria Sika Ery , Siburian Robert
Published: February 2023

Many previous studies examine social forestry in Indonesia from 2016-2020 which describing the factors relate to the implementation. Beyond the previous studies, this paper clustering and mapping the factors through access theory and further complement access theory by a collaborative approach in the social forestry implementation context. Qualitative desk research is used to examine 39 papers with Nvivo 12. The result shows there are two elements of the four elements of structure-relational access mechanism (SRAM) that have positive effects on social forestry implementation, while three elements of the five elements of the SRAM element give a negative effect. In turn, there are various unclustered factors which not a part of SRAM that affects social forestry implementation both positive or negative. These unclustered factors are the blank spaces of access theory which complemented by a collaborative approach, there are “participation” and “equity” which supported by “effective communication”. With a collaborative approach, the scope becomes wider that not only analyze in individual scope, but also in organizational scope, and the benefit can be seen by outside stakeholder through community contribution in social forestry implementation.
Examining Women, Peace, and Security Agenda in Local Concept Case study: Aceh, Indonesia
Authors: Ocktaviana Sentiela , Kamaruzzaman Suraiya
Published: February 2023

The UN security council established Resolution 1325 (SCR1325) to affirm women's vital role in peacemaking and peacebuilding in conflict. Women, Peace, and Security (WPS) agenda emphases equal participation of men and women in the negotiation process and creates gender equality in post-conflict, and eradicates gender violence in conflict. This study illustrates how women in Aceh fight for their rights throughout the conflict and post-conflict within an unequal society; and also highlights how important to adapt the WPS agenda to ensure gender equality and social justice. By applying narrative analysis, researchers enable to explore Acehnese women's experiences and struggles in seeking justice through their narratives. The implementation of the WPS agenda in Aceh faces many challenges, both structural and cultural. Thegovernment and combatant groups overlooked women's participation in peace negotiation. When the conflict ended, gender inequality is still lingering in every aspect. Aceh women experience injustice, sexual violence, and discrimination in the domestic and public sphere. Besides revealing the challenges in adapting the WPS agenda and creating gender equality in Aceh, this study also obtains policy recommendations to be considered by the local and central governments to ensure gender justice and substantial peace for women in Aceh post-conflict.
SEEDLING AND GROWTH OF Rhizophora mangle L. PROPAGULES AT A RESTORATION SITE (APA DE GUAPI-MIRIM - RJ)
Authors: Finotti Ricardo , Capinam Viviane Santos , De Oliveira Antonio Augusto
Published: February 2023

One of the biggest mangrove forests in Rio de Janeiro is located at Guanabara Bay. However, a large part of this ecosystem is currently suppressed and only 1/3 of the original 261.90 kmÂ² of mangrove vegetation can be observed. Thus, several conservation and management actions are conducted in this ecosystem. Studying plantations and other restoration strategies for this biome is important to understand the dynamics of this ecosystem and enhance such strategies. Size can be one of the most important characteristics for propagules success. Some studies state that larger seedlings can resist more and have greater survival than smaller seedlings. Therefore, this study aims to analyze the germination and development of Rhizophora mangle L. propagules at an in situ plantation in the mangroves of the Guapi-Mirim Environmental Protection Area. A total of nine plots were delimited with spacing of 4 meters by 1 meter each in which Rhizophora mangle propagules were separated into small and large groups and planted. Their germination and development were subsequently monitored for a period of 6 months. The diameter, height and initial weight of the propagules and the increase in height and diameter at 76, 93 and 154 days after planting were measured. Periodic observations were made approximately every 20 days in order to quantify the rate and type of mortality (predation, water current carriage and drying) and to monitor time (in days) of pairs of leaves opening. There were no differences between the propagules according to the size for the opening time of leaf pairs, nor for the mortality rate. The increments in diameter and height were larger for the small propagules in the first development periods, but not in the last ones. The large and small propagules did not show significant differences in diameter or height at 154 days. There was high mortality of small propagules due to predation and/or water current carriage, while the mortality for large propagules was higher due to desiccation. The results generally suggest there is no difference in the survival and development of the propagules related to size, as they are more affected by local ecological conditions.
A Juhász Gyula Tanárképző Főiskola, majd SZTE Juhász Gyula Tanárképző Főiskolai Kar Matematika Tanszékének és az SZTE Juhász Gyula Pedagógusképző Kar Tanító- és Óvóképző Intézet, majd Alkalmazott Pedagógiai Intézet Tanítóképző Tanszék Matematika Szakcsoportjának története 1998-tól 2021-ig
Authors: Krisztin Német István
Published: February 2023

Tanulmányunkban az SZTE JGYPK és jogelődjei Matematika Tanszékének és Szakcsoportjának történetét foglaljuk össze 1998-tól, a JGYTF 1999-ban kiadott, a tanszéktörténeteket bemutató kötetének lezárásától 2021-ig, a szakcsoport megszűnéséig. Az összefoglalásban kitérünk az egység helyére, vezetésére, munkatársaira, oktatására, kutatására, tehetséggondozására, kiadványaira, kapcsolataira.
Contributors
Authors: Shankar Louis
Published: February 2023

List of contributor biographies for Object Vol 24 (2023)
Theses in Progress
Authors: Shankar Louis
Published: February 2023

List of theses in progress for the 2022/23 academic year from the UCL History of Art department. 
Análisis de las propiedades psicométricas del Cuestionario de Competencias Socioemocionales SEC-Q en estudiantes universitarios chilenos
Authors:   Departamento Mediaciones y Subjetividades, Universidad de Playa Ancha, Valparaíso, Chile, Figueroa-Varela Marlen , Rodríguez Vera Montserrat ,   Universidad de Playa Ancha, Valparaíso, Chile
Published: February 2023

Introducción/objetivo: Las competencias socioemocionales median la gestión emocional y el ajuste social, son relevantes para el aprendizaje, el desempeño profesional, la salud mental y el bienestar entre otras. El objetivo de este estudio es analizar las propiedades psicométricas del Cuestionario de Competencias Socioemocionales SEC-Q en estudiantes universitarios chilenos. Método: Los participantes fueron 699 estudiantes universitarios, 493 mujeres y 206 varones. La estructura interna se analizó mediante validación cruzada, aplicando análisis factorial exploratorio y confirmatorio. La validez convergente y discriminante fue evaluada mediante correlaciones de Pearson entre las subescalas del SEC-Q con: la Escala Autoeficacia Percibida Especifica de Situaciones Académicas, Satisfacción con la vida e Inventario de Burnout de Maslach. Resultados: El cuestionario evidencia adecuadas propiedades psicométricas y los cuatro componentes del instrumento original: autoconciencia, autogestión, conciencia social y toma de decisiones; se presentan de acuerdo con lo esperado, una relación directa con autoeficacia y satisfacción con la vida, e inversa con el estrés. La conciencia social presentó diferencias según el género, siendo mayor en mujeres que en hombres. Conclusión: El SEC-Q es un instrumento confiable y válido para utilizar con estudiantes universitarios chilenos.
Memórias Cruzadas: reconstruindo a história da formação e trabalho docente em escolas primárias rurais paulista (1940-1970)
Authors: Garcia Noely Costa Dias , Chaloba Rosa Fátima de Souza
Published: February 2023

Este texto apresenta resultados parciais de pesquisa sobre a história da formação e trabalho de professores de escolas primárias rurais pertencentes à Diretoria de Ensino do município de São José do Rio Preto/SP entre 1940 e 1970. O corpus fundamental do estudo foi constituído por entrevistas realizadas com dez professores (9 professoras e um professor) que exerceram a docência em escolas rurais no período delimitado para o estudo. Além das fontes orais, são analisadas as políticas educacionais com relação à expansão do ensino primário rural, bem como a as alterações do Curso Normal, em 1971. Os resultados obtidos indicaram que os docentes tiveram dificuldades com as classes multisseriadas e a localização das escolas rurais, geralmente de difícil acesso, contudo, muitos desafios foram dirimidos com a produção de materiais de ensino, produção da merenda e compra de cartilhas para as crianças, soluções individualizadas, já que a escola rural em São Paulo nunca recebeu um planejamento sistêmico.
Helena Antipoff e Anísio Teixeira: diálogos no campo da História da Educação Especial no Brasil
Authors: Gouvêa Fernando César Ferreira , Borges Adriana Araújo Pereira
Published: February 2023

Helena Antipoff e Anísio Teixeira foram importantes intelectuais do cenário educacional brasileiro do século 20. No entanto, a relação entre eles é pouco explorada. O objetivo do artigo foi analisar essa relação, a partir do aporte teórico da História Cultural e da História Política. Foram analisadas fontes documentais, incluindo a correspondência estabelecida entre os intelectuais, a partir da mediação de outra personagem importante, Helena Dias Carneiro. Os resultados demonstram que Antipoff e Teixeira podem ser considerados intelectuais de pensamento e ação, pois os dois se dedicaram às pesquisas, mas ao mesmo tempo atuaram fortemente no campo político e institucional. Foi possível perceber ainda, afinidades teóricas, como atesta a relação de ambos com a Escola Ativa e preocupações semelhantes no que se refere ao campo educacional da época.
Discurso republicano e o debate sobre a formação do povo brasileiro na trajetória de Virgílio Cardoso de Oliveira
Authors: Damasceno Alberto , Vieira Carlos Eduardo
Published: February 2023

O objetivo deste artigo é discutir a trajetória de Virgílio Cardoso de Oliveira (1868-1935), tendo como foco a relação entre o discurso republicano e os debates sobre a formação do povo brasileiro no contexto da Primeira República, especialmente no período do entresséculos, na região amazônica. Em termos teóricos, exploraremos, o conceito de intelectual, as noções de espaço de experiência e horizontes de expectativas, além dos conceitos de jogos de linguagem e conceitos normativos. Entre as fontes utilizadas para a análise destacamos: jornais, documentos do Estado, livros e imagens. Concluímos afirmando que Virgílio Cardoso representou uma posição importante dentro do discurso e da prática republicana, ainda que seu poder de transformar a realidade educacional do país tenha sido limitada, pelas resistências, explícitas e implícitas, em tornar a República um projeto democrático e capaz de promover inclusão política e a justiça social.
A Feira de Ciências de São Paulo na imprensa brasileira (1960-1976)
Authors: Magalhães Danilo Castro , Massarani Luisa , Rocha Jessica Norberto
Published: February 2023

As feiras de ciências foram introduzidas e popularizadas no Brasil nas décadas de 1960 e 1970, como parte do movimento renovador do ensino de ciências. Neste artigo, tivemos como objetivo analisar a cobertura jornalística da Feira de Ciências de São Paulo, considerada a primeira no país. Foi feito levantamento na Hemeroteca Digital da Biblioteca Nacional e nos acervos digitais de jornais, a partir do qual identificamos 248 textos de 15 jornais, que compuseram o corpus de nossa análise. Os jornais apresentaram a Feira de São Paulo como a mais desenvolvida do Brasil, servindo de referência para a organização de feiras pelo país e internacionalmente. A análise das matérias permitiu observar também que os jornais defenderam que as feiras tinham um papel importante no movimento que visava a reforma educacional e na legitimação da ciência, inseridas em um projeto de desenvolvimento nacional baseado no fortalecimento da ciência e da tecnologia.
Os Salesianos no processo de expansão do Ensino Secundário e na formação dos jovens em Mato Grosso (1895-1951)
Authors: Sá Elizabeth Figueiredo de , Furtado Alessandra Cristina
Published: February 2023

Este artigo analisa o processo de expansão das escolas secundárias confessionais salesianas em Mato Grosso e a sua contribuição na formação civilizadora dos jovens de maior poder aquisitivo desse estado, no período de 1895 a 1951. Inicialmente, consultamos dissertações, teses e obras produzidas sobre a Ordem Salesiana no Brasil e no estado de Mato Grosso. Após, voltamo-nos para as fontes documentais, priorizando os periódicos. A análise está ancorada nos aportes de Norbert Elias. Os resultados apontaram que a atuação educacional da Ordem Salesiana se direcionou e expandiu, principalmente, para o sul do estado, onde ofereciam o ensino secundário para ambos os sexos, em escolas distintas, visando a formação civilizatória dos jovens de famílias de maior poder aquisitivo, preparando-os como líderes para atuarem na sociedade, no caso dos rapazes, e de esposas e mães conscientes de seus deveres para com a família e sociedade, no caso das moças.
O Ensino Secundário na França napoleônica
Authors: Palladino Florindo
Published: February 2023

A contribuição visa elucidar o reformismo napoleônico no campo da instrução, com foco na gênese do ensino secundário como arquitrave de um sistema educacional moderno implantado na França imperial e posteriormente estendido aos estados satélites. As reformas, implementadas entre 1802 e 1811, garantiram à França napoleônica um sistema de ensino público administrado e controlado pelo Estado, baseado em uma concepção laica que incorporava os setores privado e eclesiástico, com um sistema que se dividia prospectivamente em três graus: primário, secundário e superior, em que o liceu representou o ápice do ensino secundário e a base do segmento superior.
An experimental workflow for enrichment of low abundant proteins from human serum for the discovery of serum biomarkers
Authors: Sarihan Mehmet , Gulsen Merve , Albayrak Bal , Kasap Murat , Akpinar Gurler , Kocyigit Elifcan
Published: February 2023

Serum contains proteins that possess important information about diseases and their progression. Unfortunately, these proteins, which carry the information in the serum are in low abundance and are masked by other serum proteins that are in high abundance. Such masking prevents their identification and quantification. Therefore, removal of high abundance proteins is required to enrich, identify, and quantify the low abundance proteins. Immunodepletion methods are often used for this purpose, but there are limitations in their use because of off-target effects and high costs. Here we presented a robust, reproducible and cost-effective experimental workflow to remove immunoglobulins and albumin from serum with high efficiency. The workflow did not suffer from such limitations and enabled identification of 681 low abundance proteins that were otherwise undetectable in the serum. The identified low abundance proteins belonged to 21 different protein classes, namely the immunity-related proteins, modulators of protein-binding activity, and protein-modifying enzymes. They also played roles in various metabolic events, such as integrin signalling, inflammation-mediated signalling, and cadherin signalling. The presented workflow can be adapted to remove abundant proteins from other types of biological material and to provide considerable enrichment for low-abundance proteins.
Comparison of the Grid and Off-Grid Hybrid Power Systems for Application in University Buildings in Nigeria
Authors: Diyoke Chidiebere , Egwuagu Marcel Onyekachi , Onah Thomas Okechukwu , Ugwu Kenneth Chikwado , Dim Eberechukwu Chukwunyelum
Published: February 2023

The Nigerian Universities rely on weak and unreliable fossil-based electric grids with diesel engine generators (DEG) as a backup. However, there is a potential to light up the campuses using power systems derived from primary renewable power systems (RPS) like wind turbine (WT) and solar photovoltaic (PV), that can be on or off-grid to improve the energy mix and duration reliably. This study presents the comparative analysis of the optimal hybrid grid and off-grid systems (OGS & OOGS) for serving the demand load of university buildings in four climatic regions of Nigeria. HOMER Pro is used to design and select the systems based on minimal net present cost (NPC) and cost of electricity (COE). The impact of a minimal renewable fraction of 95% on the optimal system architecture (OSA) and COE is studied for both grid and off-grid modes. Also, sensitivity analysis of the impact of key variables on performance for the sites is carried out. It is found that the OGS in the four regions is PV/Converter (Conv), while for the OOGS, it is PV/WT/DEG/battery (BB)/Conv except in Port Harcourt (PH), where it is PV/DEG/BB/Conv. The COE for the OGS in the Savana and monsoon climes of Enugu and PH are 10 and 19% more than that in the warm-semi arid climate zones of Maiduguri and Kano, which is approximately 0.09 $/kWh. The COE ($/kWh) for the OOGS is 0.21 in Maiduguri, 0.245 in Kano, 0.275 in Enugu and 0.338 in PH. An obligatory 95% RF changes the architecture and increases COE in all the locations except Maiduguri, with a slightly improved COE but higher NPC like other locations. It is established that the suggested hybrid system is beneficial and feasible for supplying more reliable and clean energy to educational buildings in different Nigerian locations.
Capabilities and skills for manufacturing planning in an automotive use case scenario
Authors: Grimm Stephan , Haselböck Alois , Neidig Jörg , Perry Kevin , Peschke Jörn , Scharm Oliver , Schnittger Jens
Published: February 2023

The necessity for increased flexibility in production and handling of high-variant product families is a strong trend in Industry 4.0 scenarios. A promising approach to achieve this is to replace the rigid programming of the manufacturing management systems by a declarative description of machines and their functionality. This allows for a dynamic allocation of tasks to resources. This paper reports the ongoing work on applying the concept of capabilities and skills to an industrial application example in order to investigate its potential benefits. To apply the abstract concept of capabilities and skills to the production scenario it is implemented using specific technologies. These include Semantic Web ontologies, constraint solving methods and OPC UA for skill invocation and communication.
Content removal bias in web scraped data: A solution applied to real estate ads
Authors: Marconi Gabriele
Published: February 2023

I propose a solution to content removal bias in statistics from web scraped data. Content removal bias occurs when data is removed from the web before a scraper is able to collect it. The solution I propose is based on inverse probability weights, derived from the parameters of a survival function with complex forms of data censoring. I apply this solution to the calculation of the proportion of newly built dwellings with web scraped data on Luxembourg, and I run a counterfactual experiment and a Montecarlo simulation to confirm the findings. The results show that the extent of content removal bias is relatively small if the scraping occurs frequently compared with the online permanence of the data; and that it grows larger with less frequent scraping.
Fully Nonparametric Methods for Multivariate Data in Factorial Designs. Asymptotics, Finite Sample Approximations, and Implementation in R
Authors: Kiefel Maximilian , Bathke Arne C.
Published: February 2023

This article methodologically complements the R package nparMD, and it presents the follow-up to a previous article that had built the foundation for the procedure implemented initially within the package. We consider non-parametric rank-based inference methods for multivariate samples in completely randomized factorial designs. Assumption on the data are minimal: the variables need to be at least ordinal (including binary), and the multivariate observation vectors from different experimental units are assumed independent although there may be dependencies within the vectors. Different endpoints may be measured on different scales. That is, multivariate observation vectors with a count variable, a continuous metric response, and ordinal endpoints, are allowed for.

Two different asymptotic settings are considered: (1) sample sizes are large while the number of factor levels is small and bounded, (2) small samples while the number of factor levels is large. Special attention is paid to deriving inference methods for the interaction effect, as here the variance-covariance matrix does not simplify under the null. In addition, we discuss some finite sample approximations and demonstrate application of the methods using real data from a psychological study on Seasonal Affective Disorder (SAD), also commonly referred to as Winter depression
A simple PCR-SSP method for detection of HLA-B*15:02, *15:13, and *15:21
Authors: Musa Nurfadhlina , Govindasamy G. Saravana , Hoong Chew Beng , Annuar Aziati Azwari , Mohamed Noor Dzul Azri , Daud Nur Aizati Athirah
Published: February 2023

Objectives

This study aims to develop a simple polymerase chain reaction (PCR) sequence-specific primer method, which will be used to genotype HLA-B*15:02, HLA-B*15:13, and HLA-B*15:21.

Methods

DNA was extracted from whole blood using a commercial DNA extraction kit. New specific primers were designed. The PCR was optimized for reproducibility and specificity. Parameters investigated included concentrations of MgCl2, primers concentration, and annealing temperature, to produce specific bands of interest. Known DNA samples were selected at random and tested using the PCR method.

Results

Simultaneously six duplex PCRs were successfully optimized using 1.0 mM MgCl2 and an annealing temperature of 62 °C. The method was also reproducible and specific. The results from the method showed 100% concordance with known DNA samples.

Conclusions

This study has successfully developed a simple and specific method to simultaneously genotype HLA-B*15:02, HLA-B*15:13, and HLA-B*15:21 using in-house developed PCR-SSP.
Apokalipszis most? „...aki igaz, cselekedjék igazságot ezután is...” (Jel 22,11) avagy A filozófus egy puzzle bolygón
Authors: Csikai Ildikó
Published: February 2023

Apokalypse Now?Ildikó CsikaiThe critical condition of our planet and the crises of philosophy are not new phenomenons. According to a group of researchers, philosophy also needs a renewal, and not only in the proceed on the ground of evidence-based arguments and critical thinking but also it has to participate effectively in the education process for the birth of action-oriented and socially responsible citizen. The article is looking for answers if philosophy, philosophers can have any roles in the current situation, in the possible solutions of the difficulties of our planet.
Vagy soha?
Authors: Kis Pongrácz Tamás
Published: February 2023

Or never?Tamás Kis PongráczBefore I find the answer to the question: “Is there a particular relevance of the risk of apocalypse coming close, due to the pandemic?”, I try to clarify briefly how the notion of apocalypse changed through time. After that, in agreement with the spiritual evolutionism of Teilhard de Chardin and based on this theory I give reasons that human kind is not at the end of its road but it has started to grow adolescent and will truly deploy itself from now on.
Egyetemi nyelvi képzés a Közép-Duna Menti Térségben
Authors: Koltai Zoltán
Published: February 2023

University language training in the Middle Danube RegionZoltán KoltaiThe University of Pécs provided in 2021, in connection with the Paks II project, online English and Russian language learning, free of charge, for adults living or working in the settlements of the Middle Danube Region, or in the towns Bonyhád and Dombóvár. The aim of the programme was thepreparation of the inhabitants or the labour force of the area for personal communication with the foreign employers and their family members arriving for the implementation of the Paks II investment. The implementation of the training took place with the involvement of language teachers provided by two faculties of the University of Pécs: the Faculty of Humanities and SocialSciences and the Faculty of Cultural Sciences, Education and Regional Development. The paper demonstrates the major steps of the organisational process of the programme, with special emphasis on the challenges related to online implementation, and also focuses on the achievements.