bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening of Low Chill Peaches Grown under Indian Subtropics for Phenolic Compounds, Vitamins and Organic Acids
Authors: Bhattacherjee A.K. , Dikshit A. , Srivastava K.K. , Singh Achal
Published: April 2022

Background: Peach [Prunus persica (L.) Batsch] fruits are good source of phenolic compounds, vitamins and organic acids. Low chill peach cultivars require low chilling hour for bud burst and growth. Methods: Seven phenolic compounds, four vitamins and six organic acids were profiled in eight low chill peach cultivars at edible ripe stage using HPLC-PDA and evaluated using multivariate analysis. Result: Gallic acid, chlorogenic acid and catechin were the most predominant phenolic components, ascorbic acid and niacin were the major vitamins and citric acid and malic acid were the prevalent organic acids in all peach cultivars. Though not a single low chill peach cultivar possessed all the nutraceuticals in good amount, Sharbati Surkha and Sharbati contained maximum amounts of total of identified phenolic components (1472.20 and 1306.89 µg/g, respectively), whilst Sharbati, Sharbati Surkha and Pant Peach-1 had maximum amounts of total of identified vitamins (368.22, 341.48 and 335.13 µg/g, respectively). Total of identified organic acids were recorded maximum in Pant Peach-1, Pratap, Shan-e-Punjab and Sharbati Surkha (21.12, 18.70, 18.56 and 17.66 mg/g, respectively). Sharbati Surkha was the best cultivar overall while other cultivars could be used either for fresh consumption or for imparting flavor in peach based processed products.
Assessment of Brackish Water Usability for Irrigating the Coastal Sugarcane Fields under the Background of Saline Intrusion
Authors: Dinh Kim Hao Thi , Dang Truong An
Published: April 2022

Background: Globally, irrigation water deficit (IWD) due to saline intrusion and decreased rainfed continues to affect coastal cultivation regions (CCRs). Coastal lowland regions have increasingly frequent saline intrusion, resulting in the IWD as a part of climate variability. Cu Lao Dung Isle, a terrain-low coastal plain in Vietanm is facing revenue loss due to adverse cultivation conditions in recent years. Methods: The objective of this study was, therefore, to assess the effectiveness of the mixture of brackish and freshwater (MBF) for irrigating the spring crop sugarcane in the 2019/20 season grown in a household farming in Cu Lao Dung Isle. An experiment was exploded with the MBF varying from 1.5 to 5.0 dS m-1 corresponding to 100 and 120% of the crop evapotranspiration (ETc). Determination of daily ETc was conducted simulating the FAO-Penman Monteith model based on the weather data obtained using an automatic weather station, locating in the study area. Result: Based on the findings, the MBF at 3.0 dS m-1 levels corresponding to 120% of ETc was stated to be suitable for normal growth of sugarcane Khonkaen III variety. The results showed that the MBF of increasing levels varying from 3.5 to 5.0 dS m-1 significant influenced the growth process and yield of sugarcane. In general, the utilization of brackish water for irrigating in the CCRs is a suitable solution for economic efficiency.
Influence of Covid-19 Pandemic Climate, Discipline, Motivation to Performance in BAERT Kupang City
Authors: Riwukore Jefirstson Richset , Yustini Tien , Zamzam Fakhry , Habaora Fellyanus
Published: April 2022

This research aimed to analyze the influence of the Covid-19 pandemic climate, work discipline, and work motivation on the performance of the state civil apparatus. This research was implemented from January to June 2021 at the Body of Apparatus, Education, and Training of Kupang City. The research method in this article uses a quantitative approach. The population and sample in this study were 123 ASN in the Body of Apparatus, Education, and Training of Kupang City. At the same time, the data analysis technique used multiple linear regression analysis. This study indicates that the Covid-19 pandemic climate and work discipline have no effect on employee performance, but work motivation positively influences employee performance. Simultaneously, the Covid-19 pandemic climate variables, work discipline, and work motivation positively and significantly influence employee performance.
Workplace Spirituality as Mediator the Influence of Leadership Style on Employee Performance
Authors: Ekowati Vivin Maharani
Published: April 2022

This study aims to know the direct effect of leadership style on employee performance and test and analyze workplace spirituality's role as a mediator influencing leadership style to performance of employees. The target population of this study was employees of Indonesian Islamic banks in Malang Raya, totaling 310 employees. Sampling was done by proportional random sampling, using Slovin formula with a tolerable error rate of 10 percent, then obtained a total sample of 76 employees. Data were collected directly from respondents using a questionnaire instrument. The data analysis technique used is Path Analysis. The results of the study prove that leadership style has a significant effect on employee performance. Workplace spirituality mediates influence leadership style on employee performance.
The Contribution of Anatoly Fedorovich Koni to the Development of the Criminal Process at the Beginning of the 20th Century
Authors: Kodintsev A. Ya.
Published: April 2022

Based on a set of archival materials, the article shows the evolution of the views of the famous Russian lawyer Anatoly Fedorovich Koni in the 1900-1910’s on the essence and principles of the criminal process. Koni developed his creative potential in three aspects: practical, theoretical and legislative. At the beginning of the twentieth century, the theoretical and legislative activities of the senator came to the fore. As a practical lawyer, he actively participated in the drafting of comments on the Charter of criminal proceedings (where he gave a scientific assessment of the final debate in court, the accusatory speech of the prosecutor, the private prosecution, the defense speech of the lawyer, the conclusion of the prosecutor in cassation proceedings, etc.). As a participant in the legislative process, Koni defended in the State Council (in the early 1910s) bills aimed at improving procedural law. He defended the preservation of the rite of trial, insisted on changing the clarification to jurors of the issue of punishment for the accused, limiting the powers of the justice of the peace, etc. The role of the senator was especially active in 1917, when, as chairman of the subcommittee to change the Charter of Criminal Procedure, Koni had a decisive influence to change the judicial process in the Russian Republic. A huge contribution to the development of the foundations of criminal justice was made by the work of Anatoly Fedorovich – Judicial Ethics. In it, he set a high ethical and legal standard of conduct for all participants in the process. The study analyzes in detail those legal institutions of the criminal process that have become the object of study by the senator. Including the principles of procedural law, the procedure for considering cases of crimes of the press, the procedure for the rite of passage to court, the procedure for explaining to jurors the consequences of their sentence, the status of a private attorney, the status of a prosecutor in court, etc. The senator's ideas about the evolution of procedural norms are considered separately. The purpose of this work is to establish the contribution of A.F. Koni in the development of criminal justice through his theoretical and legislative activities. In preparing the publication, the problem-chronological method, as well as the historical method, were used.
AHMED FERÎD’İN MANZÛME-İ SE ZEBÂN-I AKÂİD-İ ADÛDÎ ADLI ESERİ (EDİSYON KRİTİK VE ÇEVİRİ)
Authors: SÜSLÜ Zahir , ŞİMŞEK Şahin
Published: April 2022

Klasik Türk edebiyatı içerisinde tevhid, mevlid, siyer, miraç, naat, akaid, fıkıh gibi dinî konulubirçok manzum eser yazılmıştır. 19. yüzyılda yaşadığı bilinen ancak hayatı hakkında pek bilgibulunmayan Ahmed Ferîd’in üç dilde yazdığı mesnevisi de dini konuludur. Ahmed Ferîd,Adudüddin el-Îcî’nin “el-Akâidü’l-Adudiyye” isimli eserini manzum formata soktuktan sonraFarsça ve Türkçeye manzum formatta tercüme etmiştir. Şair, Adudî’nin eseri haricindeCelâlüddîn Muhammed ed-Devvânî’nin “Şerhu’l-Akaidi’l-Adudiyye”si ile Mehmet FevziEfendi’nin “el-Cemâlü’d-Deyyânî ale’l-Celâli’d-Devvânî” isimli eserlerinden de faydalanmıştır.Eser dönemin Şeyhülislamı Sadeddin Efendi’ye ithaf edilmiştir. Eserin üç dilde yazılmışolması, klasik dönem edebiyatı açısından son derece önemlidir. Ahmed Ferîd, Adudî’ninakaidini 76’şar beyitlik Arapça, Farsça ve Türkçe beyitlerle anlatmıştır. Eserin sonuna 25beyitten oluşan Türkçe-Farsça sözlük eklemiştir. Akaid eseri yazan her şair gibi bu geleneğidevam ettiren Ahmed Ferîd de, eserini sanat kaygısında uzak tamamen didaktik bir amaçlayazmıştır.Bu makale, Ahmed Ferîd adına Çorum İl Halk Kütüphanesi 19 Hk 1084/2 arşiv numarada kayıtlıbir akaid manzumesinin incelemesidir. Çalışmaya öncelikle, akaid ilmi ve klasik Türk edebiyatıdöneminde yazılmış manzum akaid eserleri hakkında bilgi verilerek başlanmıştır. Sonrasındasırasıyla; eserin tercüme edildiği kaynak ve müellifi, incelenen eserin müellifi, eserinnüshaları, eserin yazılış tarihi ve sebebi, eserin şekil özellikleri ve muhtevası gibi konularadeğinilmiştir. İncelemeden sonra eser, Latin harflerine aktarılmıştır.
Different expression of NF-kB and endometrial implant width in the administration of red fruit (Pandanus conoideus Lam) and leuprolide
Authors: Hikmah Raudatul , Hendarto Hendy , Widjiati Widjiati
Published: April 2022

HIGHLIGHTS
1. Endometriosis treatment remains controversial, whether it should be managed with hormonal modulation and/or surgical removal of the lesion.2. NF-kB becomes potential therapeutic target as it has constitutive activation in peritoneal endometriosis.3. It has been recognized that NF-kB expression decreases when red fruit extract is given.4. Effect of red fruit extract, compared to leuprolide, a widely used treatment for endometriosis, on NF-kB expression was examined.5. NF-kB was significantly lower in endometriotic group receiving red fruit extract than in group receiving leuprolide.
 
ABSTRACT
Objectives: This study aimed to prove the effect of different administration of red fruit (Pandanus conoideus Lam) extract and leuprolide on the expression of NF-kB and endometrial implant width in mouse models of endometriosis.
Materials and Methods: This study used completely randomized design with pre-post separated sample. The sample size was 36 female mice (Mus muculus), which were divided into 3 groups randomly. They were given with cyclosporine A, estrogen and endometrial tissue to form endometriosis model.
Results: The mean expression of NF-kBin in treatment group receiving leuprolide (4.13 + 0.70) and red fruit (2.70 + 1.08) were significantly lower than that in control group (6.94 + 1.007). Whereas, in treatment group receiving red fruit (2.70 + 1.08), it was significantly lower than in those receiving leuprolide (4.13 + 0.70). Mean endometrial implant width in treatment group receiving leuprolide (13.62 + 3.21) and red fruit (8.93 + 2.74) were significantly lower than that in control group (28.89 + 8.28). Whereas, in treatment group receiving leuprolide (13.62 + 3.21), it was not significantly higher than in those receiving red fruit (8.93 + 2.74).
Conclusion: The expression of NF-kB was significantly lower after the administration of red fruit than leuprolide. The width of endometrial implant was not significantly lower after the administration of red fruit than after the administration of leuprolide.
Contraception method among pregnant women with HIV delivered in Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Authors: Indarti Junita , Pangestu Shinta , Anggayana Adri Dwi , Rifiranda Cherysa , Prameswari Natasya , Alda Kristian
Published: April 2022

HIGHLIGHTS
1. HIV transmission from HIV positive mothers to their children should be reduced by strengthening family planning programs.2. Characteristics of contraceptive methods among women with HIV infection delivered in a tertiary hospital were investigated.3. IUD was the most common contraceptive method used by women with HIV infection. Its use was related to age, gravida and method of delivery.
 
ABSTRACT
Objectives: The aim of this study was to describe characteristics of contraceptive methods among women with HIV infection who delivered in a tertiary hospital.
Materials and Methods: This was a cross-sectional study. The inclusion criteria were pregnant women with HIV infection who delivered in Cipto Mangunkusumo General Hospital (RSCM), Jakarta, Indonesia, from January 2016 to December 2020. Data were retrieved from medical records, registered HIV and laboratory result. The included data were  demographic data, obstetric data, mode of delivery, contraception method, ARV history, and laboratory history of the mothers.
Results: From January 2016 to December 2020 there were 119 HIV patients who delivered at the RSCM. Most of the subjects were 35 years old (84%), had low education (52.9%) and worked as housewives (76.5%). A total of 79.8% of the subjects were gravida >2 and most of the subjects delivered by caesarean section (87.3%). The choice of contraceptive methods were IUD (72.4%), tubectomy (26.8%) and implants (0.8%). There was a statistically significant relationship between contraceptive method with age (p 0.040), gravida (p 0.016) and delivery method (p 0.049)
Conclusion: The most common contraceptive method was IUD. The choice of this method of contraception was related to age, gravida and method of delivery.
Educación y apoyo familiar, y logro en matemáticas en dos contextos sociodemográficos diferentes
Authors: Bazán-Ramírez Aldo , Hernández-Padilla Eduardo , Castellanos-Simons Doris
Published: April 2022

Este trabajo presenta los resultados de un estudio no experimental, transversal, realizado bajo un diseño explicativo-mixto (con variables manifiestas y latentes) en una escuela indígena de zona rural y una escuela urbana de Morelos (México). Se consideró al contexto sociodemográfico de las escuelas de procedencia como variable predictora del logro en matemáticas en 6to grado de primaria, y como variables mediadoras, el nivel educativo de los padres y el apoyo familiar. Al término del 6to grado, los alumnos de ambas escuelas respondieron una escala sobre apoyo familiar y una prueba corta sobre dos competencias matemáticas: Comunicar información matemática y Manejar técnicas de manera eficiente. Los datos se analizaron mediante dos modelos de regresión estructural de relaciones entre variables manifiestas (contexto escolar y nivel educativo de los padres) y variables latentes (apoyo familiar con ocho ítems y logro en matemáticas con dos índices de competencias matemáticas). El logro en matemáticas fue la variable latente final a explicar. Ambos modelos resultantes mostraron que el logro en matemáticas fue explicado significativamente y de forma positiva por la variable latente Apoyo Familiar, y de manera indirecta y positiva, por la variable manifiesta Educación de los padres, variable que a su vez fue explicada de forma significativa pero negativamente, por la variable manifiesta contexto de procedencia de la escuela. Los hallazgos respaldan la hipótesis de que las oportunidades de aprendizaje de los estudiantes dependen en gran medida del contexto socioeconómico y educativo de las familias, los cuales están determinados por el entorno demográfico y físico donde se vive y se estudia.
Percepción de la calidad de vida urbana en residentes del Área Metropolitana de Monterrey, México: su importancia psicoeducativa
Authors: García-Luna Romero Ana , Malvaceda-Espinoza Eli
Published: April 2022

La expansión urbana es un fenómeno de suma importancia para quienes habitan en grandes ciudades y sienten los efectos de la misma, lo cual puede afectar su calidad de vida. Al respecto, el objetivo de la presente investigación es conocer la percepción del ser urbano en relación a la calidad de vida urbana en el área metropolitana de Monterrey, México. Se realizó una investigación cualitativa, de diseño de análisis temático. Participaron 24 personas residentes de la zona metropolitana de Monterrey. Se aplicó una entrevista en profundidad semiestructurada. Como resultados se encontró que la calidad de vida urbana puede ser entendida a través de las calidades externas, tales como el estándar de vida adecuado a sus necesidades; e internas, tales como la felicidad urbana, los estilos de vida urbana y el repensar el vínculo sociedad y naturaleza. Se concluye que tanto la percepción de las calidades externas, e internas afectan a la calidad de vida urbana. Asimismo, su conocimiento es de importancia para la formulación intervenciones psicoeducativas que mejoren la calidad de vida urbana en los residentes.
Mesenchymal stem cell-derived extracellular vesicles for cell-free therapy of ocular diseases
Authors: Liu Xiaoling , Hu Liang , Liu Fei
Published: April 2022

Mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) have noticeably attracted clinicians’ attention in treating ocular diseases. As the paracrine factor of MSCs and an alternative for cell-free therapies, MSC-EVs can be conveniently dropped over the ocular surface or diffused through the retina upon intravitreal injection, without increasing the risks of cellular rejection and tumor formation. For clinical translation, a standardized and scalable production, as well as reprogramming the MSC-EVs, are highly encouraged. This review aims to assess the potential approaches for EV production and functional modification, in addition to summarizing the worldwide clinical trials initiated for various physiological systems and the specific biochemical effects of MSC-EVs on the therapy of eye diseases. Recent advances in the therapy of ocular diseases based on MSC-EVs are reviewed, and the associated challenges and prospects are discussed as well.
THE COVID-19 IMPACTS ON THE HOSPITALITY INDUSTRY HIGHLIGHTS FROM EXPERTS IN PORTUGAL
Authors: Almeida Sofia , Mesquita Susana , Carvalho Inês
Published: April 2022

Purpose - To better understand the impact of COVID -19 on the tourism sector, with a focus on the hospitality industry, and how these changes will affect the sector and business responsiveness. Design - This is research focusing on the COVID-19 impacts on the hospitality sector in Portugal. The study reports in detail how a group of experts perceived this critical situation caused by the pandemic. Methodology - For data collection, a focus group was conducted with six experts in the field. A thematic analysis was conducted to interpret the data and NVivo software was used to organise and define the themes. Findings - Experts emphasised the massive collective dismissals in large hotel chains, the possible loss of 50 million jobs in the tourism sector, and the negative impact on the entire value chain. The low occupancy rate had a negative financial impact, as total revenues in the sector plummeted by more than 70% compared to the previous year. This pandemic required significant adjustments from operations to ensure safe operations. Participants not only stressed the importance of motivating and bringing teams together, but also described strategies to increase employee engagement. Another area of growth during the pandemic was food delivery platforms. Originality of the research - This is the first time research describing economic, financial, organizational, operational, and technological impact of COVID -19 on the hospitality industry. Hopefully these study results will help hotel and restaurant managers better plan their strategy following this pandemic.
Absorption Spectra Comparison of Tm/Ho-Codoped Bototellurite Glasses
Authors: Saraswati Azmi , Marzuki Ahmad , Suryanti Venty
Published: April 2022

This paper presents a comparison study of absorption spectra of borotellurite glasses with compostion: 20TeO2 – 15Bi2O3 – 3TiO2 – (4-x) Na2CO3 – 1Tm2O3 - xHo2O3 where x = 0; 0.5; 1; 1.5; 2; 2.5 (mol%). All glasses are fabricated using melt quenching method. Absorption spectra were recorded at room temperature in the spectral range of 200 – 1100 nm. Within this range, glass with x = 0 mol % of Ho2O3 shows 2 absorption peaks which corresponds to electronics transition from 3H6 to state to 3F3 and 3H4.   For x = 0.5; 1; 1.5; 2; 2.5 (mol%), nine absorption peaks corresponding to electronics transition from 3H6 to state to 5G5, 5G6, 1G4, 1G4, 5F3, 5F4, 5F5, 3F3, and 3H4 are shown. It is shown that absorption at 680 nm and 790 are insensitive to the addition of Ho2O3 in contrast to that at 580 nm and 650 nm.
Foundational Problems of Quantum Theory: Novel Approach to Temporal Probability Density
Authors: Erol Mustafa , Kuzucu M. Emre
Published: April 2022

Present study focuses on some foundational problems of quantum theory specifically deals with the concept of probability density and relating introductory problems. In this sense, the work initially investigates the origins of the general probability theory and re-examines the concepts of spatial and temporal probability densities based on genuine epistemological and ontological arguments. In order to tackle the foundational problems, standard theory is primarily memorised and criticized scientifically and philosophically in terms of foundationally disappearing term of time dependent potential energy within the time and space dependent Schrödinger wave equation. Based on those arguments, the problematic inconsistency between the spatial and temporal probability density functions is underlined. Given the problem, an original approach previously suggested, is concisely described and extended to resolve the existing problem. The novel approach, based on a novel time dependent Schrödinger wave equation, resolves the discrepancy with the classical wave equation and also leads to time dependent temporal probability densities even for the time free potential energies. Novel temporal probability density function is also normalized and has a fluctuation period of around 10-16 s which is very short compared to the atomic time scales.
Analisis Pelaksanaan Proyek Konstruksi dengan Metode Earned Value pada Pembangunan Hotel Santika Bukittinggi
Authors: Honesti Leli , Wiranto Rendra
Published: April 2022

Pembangunan infrastruktur dan proyek konstuksi di kota Bukittingi semakin meningkat. Salah satu infrastruktur yang dibangun saat ini adalah Hotel Santika Bukittinggi yang digunakan sebagai tempat penginapan yang memiliki fasilitas kamar, hiburan serta layanan yang mewah. Proyek pembangunan hotel tersebut dijadwalkan selesai dalam masa 365 hari kalender. Semua daya upaya harus dilakukan secara matang agar biaya dan waktu proyek menjadi lebih terkendali. Tujuan dari penelitian ini adalah untuk menganalisa kinerja proyek berdasarkan waktu dan biaya, prakiraan waktu total dalam penyelesaian pekerjaan proyek konstruksi dan prakiraan biaya total proyek berdasarkan metode Earned Value. Data yang digunakan adalah data sekunder yang didapat dari kontraktor pelaksana. Data yang digunakan meliputi data RAB, RAP dan Time Schedule. Konsep earned value terdiri dari tiga indikator yaitu Budget Cost of Work Schedule (BCWS), Budget Cost of Work Performance (BCWP), dan Actual Cost of Work Performance (ACWP). Dari ketiga indikator tersebut, dilakukan analisis Cost Varians (CV), Cost Performance Index (CPI) dan Schedule Performance Index (SPI). Setelah menghitung bermacam indeks tersebut maka dapat dihitung Estimate to Complete (ETC), Estimate at Completion (EAC) dan Estimate all Schedule (EAS). Hasil penelitian menunjukkan kinerja proyek mengalami keterlambatan, ini terlihat dari data perhitungan analisis penilaian kinerja proyek SV<0 dan dari indeks kinerja jadwal didapat SPI < 1.
Beton Ringan dengan Bahan Plastik sebagai Agregat Kasar untuk Konstruksi di Atas Lahan Gambut
Authors: Basri Doni Rinaldi , Mubarak Husni
Published: April 2022

Provinsi Riau merupakan wilayah yang memiliki lahan gambut yang terluas di Sumatra 4,044 juta Ha (56,1% dari luas lahan gambut Sumatera atau 45% dari luas daratan Propinsi Riau). Tanah gambut memiliki daya dukung rendah, tingkat kompresibilitas yang tinggi dan kandungan air yang juga tinggi sehingga kurang baik digunakan sebagai pendukung bangunan konstruksi. Oleh karena itu untuk menahan konstruksi yang berada di atas tanah gambut perlu inovasi baru terhadap betonnya yaitu menggunakan beton ringan. Pada penelitan beton ringan ini agregat kasar (batu) diganti menggunakan plastik PET (polyethylene terephthalate) selanjutnya dilakukan analisis uji tekan beton dan massa/berat beton. Tujuan pengujian tersebut adalah untuk mangetahui campuran plastik yang mana tergolong dalam beton ringan dan cocok digunakan untuk konstruksi di atas lahan gambut. Manfaat dari penelitian ini adalah membuat beton ringan yang bisa digunakan pada lahan gambut. Penggantian agregat kasar dengan plastik PET dibuat dengan variasi campuran 0%, 40%, 50%, 70% dan 100%, dari hasil pengujian campuran 70% dan 100% yang termasuk beton ringan dengan berat 6.4 Kg dan 5.81 Kg. Pada capuran 70% PET mutu beton K-193 termasuk beton ringan dengan kekuatan menengah, sehingga campuran ini dapat digunakan pada konstruksi lahan gambut.
Estimasi Model Geoid Tanpa Koreksi Adiktif Menggunakan Metode Modifikasi Kuadrat Terkecil Untuk Pulau Sumatera
Authors: Guvil Quinoza , Zola Guvil Febio
Published: April 2022

Geoid merupakan referensi tinggi di Indonesia sesuai amanat Peraturan Kepala BIG (Perka BIG) nomor 15 Tahun 2013 tentang Sistem Referensi Geospasial Indonesia (SRGI). Pemodelan geoid memberikan informasi penting dalam penentuan tinggi ortometrik dengan menggunakan teknologi Global Navigation Satellite System (GNSS). Penentuan model geoid yang tepat adalah salah satu tujuan utama penelitian ini. Ada beberapa pendekatan dalam penentuan model geoid. Dalam penelitian ini, pendekatan kuadrat terkecil dievaluasi dalam penentuan estimasi model geoid gravimetri untuk Pulau Sumatera. Himpunan parameter: M = L = 180, Ψ_0 = 3. 0 dan σ_Δg = 5.0 mGal ditentukan untuk memberikan nilai optimal untuk penentuan model geoid Pulau Sumatera yang sesuai dengan menggunakan pendekatan kuadrat terkecil. Nilai yang diperoleh dari model geoid gravimetri yang diestimasi dengan membandingkan nilai yang diketahui pada benchmark (BM) yang sudah ditentukan. Estimasi perhitungan model geoid gravimetri dengan metode Root Mean Square Error tanpa koreksi aditif adalah ±32,1cm. Secara umum, pendekatan tersebut memiliki akurasi dan potensi tinggi dalam menentukan model geoid yang tepat untuk Pulau Sumatera.
MENINGKATKAN LITERASI DAN MINAT BACA ANGGOTA TAMAN BACA ABDUROHMAN
Authors: Trisnani Novy , Utami Wulan Tri Puji
Published: April 2022

This service activity is a collaboration between the Service Team and Taman Baca Abdurohman. Taman Baca Abdurohman at the beginning of its establishment was the initiation of a community group in RT.13/08 Panjatan, Kulon Progo. The purpose of establishing the Taman Baca Abdurohman is to facilitate children in the surrounding environment who like to read or want to read but are hindered by economic affordability. In addition, the purpose of establishing the Taman Baca Abdurohman is to increase interest in reading and improve literacy, especially for children around and in general the community in the reading park environment is located. Children as the main users of the benefits of Taman Baca Abdurohman's have a tendency to like folklore and fairy tales. With the advancement of science and technology, of course, adjustments must be made by Taman Baca Abdurohman. The service team and partner cooperation programs implemented to achieve these goals are empowerment and mentoring. Empowerment activities are carried out through adding to the collection of books in Abdurohman's reading park and implementing empowerment for PKK mothers around the reading park locations, mentoring activities are carried out through the provision of English language tutoring and competitions. The results of the evaluation of the service program showed that there was an increase in the number of visits by members of the Taman Baca Abdurohman and the general public to the place. So it can be concluded that the solution provided by the service team is appropriate to overcome the problems that exist in Taman Baca Abdurohman's.
The Effect of Unloading Path on the Time-Dependent Behavior of Beishan Granite
Authors: Yu Peiyang , Pan Peng-Zhi , Feng Guangliang , Wang Zhaofeng , Miao Shuting
Published: April 2022

Understanding the time-dependent characteristics of Beishan granite after excavation is critically important for the long-term stability and disaster control of the high-level radioactive waste repository. In this context, a series of creep tests under different unloading paths are designed to simulate the time-dependent behavior of rock mass after excavation. Results show that the instantaneous volume deformation under each loading step is greatly influenced by the unloading path. Moreover, the unloading path has minor effects on the creep strain. The axial and lateral creep strain is dominated by creep fracture potential, which can be characterized by a unified time-dependent fracture potential index (ξTFPI) for different stress states. It is observed that the creep strain generally increases with increasing ξTFPI. In order to describe the fracture mechanism during the creep process, a damage mechanical model based on time-dependent subcritical crack growth theory is adopted. It reveals that the strain hardening behavior dominates the granite creep process, and the strain softening effect is gradually strengthened with increasing ξTFPI.
Snow monitoring in midlatitude lowlands using SAR backscattering ratio
Authors: Rimkus Egidijus , Kilpys Justinas
Published: April 2022

In this study we tested and evaluated an algorithm for generating binary snow maps using Sentinel-1 SAR data on various land cover types in midlatitude lowlands. The SAR data was acquired over the Šventoji river basin in Lithuania and included five cold seasons from 2014 to 2021. Snow classification was done by thresholding SAR backscattering ratio between the image with snow and the reference image based on the snow-free SAR observations in autumn. We used ground range dual-polarized Sentinel-1 data and calculated the weighted VV and VH polarization ratio to determine land cover type-specific snow classification thresholds. The validation of snow maps derived from SAR data was done using Sentinel-2 images. Validation results showed that accuracy of SAR based snow maps over grasslands and arable land was within a 0.85–0.92 range, while in the coniferous forests it was 0.49. Results suggest that the most important factors influencing the accuracy of snow detection using Sentinel-1 SAR data are snow depth and dense forest vegetation. The study contributes to the evolving SAR-based algorithms to determine snow cover characteristics and demonstrates the capability of the Sentinel-1 mission for snow monitoring in various landscapes.
Clinical characteristics and prognosis of patients with glioblastoma with infratentorial leptomeningeal dissemination
Authors: Kawauchi Daisuke , Ohno Makoto , Honda-Kitahara Mai , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Tamura Yukie , Kikuchi Miyu , Ichimura Koichi , Narita Yoshitaka
Published: April 2022

Objective
Leptomeningeal dissemination (LMD) is a severe complication of glioblastoma (GBM) and has become a more common and indispensable clinical proposition with improved patient prognosis. Although infratentorial leptomeningeal dissemination (ITD) of GBM is rare, it is clinically significant as it may largely influence patient prognosis. Here, we investigated the clinical characteristics and prognosis of patients with ITD.
Methods
Data of patients with newly diagnosed isocitrate dehydrogenase (IDH)-wildtype GBM treated at our institution between October 2008 and December 2018 were reviewed. ITD was defined as the dissemination of GBM, which first emerged as a supratentorial tumor, and later disseminated in the infratentorial region as the first recurrent site.
Results
Of 160 patients with newly diagnosed IDH-wildtype GBM, seven (4.4%) were classified as having ITD. ITD lesions were in the fourth ventricle in two patients, extra-cerebellum or extra-brainstem in two, and intra-cerebellum in three. The primary symptoms of ITD were gait disturbance (85.7%, n = 6), nausea and vomiting (28.6%, n = 2), cerebellar mutism (14.3%, n = 1), and none (14.3%, n = 1). In four cases (57.1%), symptoms were confirmed before ITD discovery. The median progression-free survival (PFS) and overall survival of the patients were 12.2 and 19.7 months, respectively. Radiotherapy was performed in five patients, and all the patients received chemotherapy. The PFS and overall survival rates from ITD diagnosis were 2.9 and 7.1 months, respectively. Patients with favorable prognoses were younger and had higher Karnofsky performance status (KPS) scores.
Conclusions
Radiotherapy or molecular-targeted therapy may be effective in some cases of ITD and may contribute to extending survival. Carefully checking the infratentorial region of patients with GBM during follow-up and rapidly treating ITD before their KPS score starts declining are crucial.
Impact of short segment fixation on Spinopelvic Sagittal Alignment in Thoracolumbar Fracture Cases
Authors: Li Kepeng , Ma Guoju , Zhao Heyi , Han Ye , Zuo Jinzeng
Published: April 2022

Background: Thoracolumbar kyphosis induced by spinal fractures can alter the overall sagittal alignment. There is a lack of literature analyzing the effects of short segment fixation on spinopelvic parameters in patients with spinal burst fracture. This study aimed to explore the impact of short segment fixation on spinopelvic sagittal alignment in patients with thoracolumbar fractures.Methods: We performed a retrospective analysis of thoracolumbar fracture cases treated with short-segment fixation surgery at our institution from February 2018 to July 2022. Perioperative radiographs of 42 patients were obtained. The pelvic and spinal parameters were measured, and the influence of fracture site on all parameters was retrospectively analyzed. A descriptive analysis characterizing these parameters and multivariate analysis was performed to investigate the influencing factors of thoracolumbar kyphosis.Results: The mean age of included cases was 47.1±9.9 years, Pelvic incidence was 44.1±4.7º. Preoperative fractured level kyphosis (FLK) and thoracolumbar kyphosis(TLK) were 10.3±9.9º and 15.6±10.4º, respectively. Operative corrected degree(OCD) of FLK and TLK were 6.8±7.9º and 7.7±8.4º, respectively. Preoperative parameters, including FLK, TLK, Pelvic tilt (PT), Sacral slope (SS), Lumbar lordosis (LL), were no different in the different fracture sites. PT-OCD is greater in L2～L5 fractures than in T12～L1(t=0.82, P=0.03). FLK-OCD(B=0.36), LL-OCD(B=-0.34) and PT-OCD(B=0.22), as well as age(B=-0.23) were independent factors to influence TLK-OCD. pelvis anteversion and high FLK-OCD was associated with a more satisfactory correction of the TLK deformity. TLK-OCD was negatively influenced by age. Conclusions: Short segment fixation surgery can correct TLK caused by fractures. Satisfactory TLK-OCD is related to excellent fracture reduction, pelvic anteversion, and younger patients. With FLK fixed by operation, the pelvis rotates from rear to front, more obviously in lumbar fractures.
Intersectionality and the Invisibility of Transgender Health in the Philippines
Authors: Abesamis Luis Emmanuel Ang
Published: April 2022

The vulnerability of the Filipino LGBTQI + community to health problems is disproportionately experienced by trans Filipinos. Because of the institutional prejudice and discrimination against trans Filipinos in Philippine society, an intersectional approach presents an opportunity to analyze the invisibility and potentially elucidate the unique health needs of trans Filipinos. This paper reviews the literature to elucidate how the invisibility of trans Filipinos in health is a product of co-existing and interacting prejudiced and discriminatory institutions, such as the law, education, and medicine, where the historical experiences of colonization, the hegemony of cisgenderism, and the impact of capitalism remain salient. By elucidating these co-existing and interacting structures and forces, the gaps in Philippine healthcare system are surfaced. In light of this, recommendations for future research and policy work are made vis-à-vis creating and cultivating a more trans inclusive and responsive healthcare system in the Philippines.
The efficacy and safety of roxadustat in anemia treatment in hemodialysis patients with erythropoietin-hyporesponsiveness
Authors: Zou Yang , Chang Dan , Wang Amanda Y , He Jingdong , Li Mingzhu , Cai Yanrong , Wei Jinxi , Yang Dongmei , He Dong , Lei Min , Deng Fei , He Qiang , Xue Hen , Hong Daqing , Li Guisen
Published: April 2022

BackgroundErythropoietin is an important drug for the treatment of anemia in hemodialysis patients. However, many patients show erythropoietin-hyporesponsiveness. Roxadustat has been shown to be effective in treating patients with anemia due to chronic kidney disease. However, its efficacy and safety in hemodialysis patients with erythropoietin-hyporesponsive anemia remain unclear.MethodsErythropoietin-hyporesponsiveness was defined as erythropoietin dose of more than 450U/kg intravenously or 300U/kg subcutaneously for 16 weeks, with hemoglobin rising rate below 1 g/dL/month or 11.0 g/dL. A cohort of hemodialysis patients with anemia and a low response to erythropoietin from January 2020 to December 2020 were treated with roxadustat for 12 weeks to observe changes in hemoglobin, iron metabolism, blood lipid, and inflammatory indicators and to evaluate the safety and efficacy of roxadustat.ResultsThere were 56 patients with erythropoietin-hyporesponsiveness, and a total of 44 patients (78.6%) completed the 12-week follow-up, including 16 males (36.4%); patient ages were 54.6±14.2 years. The mean initial treatment dose of roxadustat was 104.4±12.4 mg thrice a week. At week 12, 30 subjects (68.2%) met the protocol-defined primary efficacy endpoint. After 12 weeks of treatment, hemoglobin was significantly increased from 7.81±1.36 g/dL to 9.80±1.94 g/dL (P<0.001), serum ferritin, serum total cholesterol and triglyceride were significantly decreased. While white blood cells and neutrophils significantly increased than baseline.ConclusionThis study indicated that roxadustat significantly increases hemoglobin levels, improving iron absorption and utilization, reducing cholesterol and triglyceride levels, with good short-term safety profile in hemodialysis patients with erythropoietin-hyporesponsive anemia.
Optimum cultural conditions to achieve the best biofilm formation by Staphylococcus aureus
Authors: Sharifi Aram , Mohammadzadeh Abdolmajid , Mahmoodi Pezhman , Salehi Taghi Zahraei
Published: April 2022

The aim of this study was to investigate the influences of different broth culture media supplemented with glucose, on the biofilm formation and ica expression of Staphylococcus aureus. The phenotypic ability to adhere to a polystyrene surface and to produce slime layer were evaluated using microtiter plate test (MtP) and Congo red tube test, respectively. Using PCR, the presence of ica locus in S. aureus strains was confirmed and subsequently, quantitative real-time RT-PCR was performed to investigate transcription of icaA in various media including Tryptic soy broth (TSB), Brain-heart infusion broth (BHIB), (Nutrient broth) NB and (Muller-Hinton broth) MHB contained 0, 0.25, 0.5, 1 and 2% glucose. Our results showed that although all of the studied strains adhered to the wells of polystyrene microtiter plates, the optimum rate of biofilm formation was observed for TSB medium contained 1% glucose, but biofilm formation was not significantly different in NB, MHB and BHIB media. Supplementation of all media with 1% glucose led to the highest production of biofilm formation and in all of media transcription of icaA was increased with glucose addition to one present. The results of the present study indicated that TSB medium supplemented with 1% glucose was the most appropriate medium for evaluation of biofilm formation by S. aureus isolates.
Pleural manometry during thoracocentesis in patients with malignant pleural effusion: A randomized controlled trial
Authors: Hassaballa Aly Sherif , Mostafa Ahmed , Haikal Tamer , Elnori Ahmed , Elsayed Hany Hassan
Published: April 2022

Background
Large volume therapeutic thoracentesis may be associated with re-expansion pulmonary edema RPE. Without the use of pleural manometry, this limits the amount of fluid drained. We investigated whether monitoring of pleural pressure with manometry during thoracentesis would avoid RPE or allow larger volume drainage.
Research Question
We wanted to see if using manometry to measure pleural pressure during thoracentesis may help minimize RPE or allow for more volume drainage.
Patients and Methods
We did a randomized controlled trial involving 110 patients with large malignant pleural effusions. Patients were randomly allocated to obtain thoracentesis with or without pleural manometry. The primary outcome was overall chest discomfort symptoms, the amount of fluid aspirated, and pleural pressures. This trial is listed on ClinicalTrials.gov as NCT04420663
Results
The mean amount of total paracentesis fluid withdrawn from the control group was 945.4 ± 78.9(ml) and 1690.9 ± 681.0(ml) from the cases group (p < 0.001). clinical signs of RPE appeared in (n = 20) (36.3%) of patients of cases group while no signs of RPE appeared in controls (p-value < 0.001). opening pleural pressure was 13.4 ± 12.7 cm H2O in non-REP cluster vs 23.5 ± 5.7 cm H2O in REP cluster (p-value = 0.002). The difference between opening and closing pressures between the non-REP and REP cluster was (32.8 ± 15.6 vs 42.2 ± 13) respectively. (p-value = 0.02). Total fluid withdrawn from non-REP was 1828.5 ± 505ml in comparison to 1450 ± 875ml in the REP cluster (p-value = 0.04)
Interpretation
Pleural manometry is useful in malignant pleural effusion to increase the amount of fluid withdrawn But has no role in preventing RPE. The drop of pleural pressure of more than 17cm H2O should be avoided. Our findings do not support the routine use of this approach.
Diffusive regimes in a two-dimensional chiral fluid
Authors: López-Castaño Miguel Ángel , Reyes Francisco Vega , Rodríguez-Rivas Álvaro
Published: April 2022

We have found strong experimental evidence of odd diffusion in a chiral fluid (composed in this case of a set of identical disk-shaped rotors); i.e., in general — but not always— the chiral fluid displays strong anisotropic diffusion, represented here by an antisymmetric two-dimensional tensor. In particular, we show that chiral diffusion is strikingly complex (featuring transitions between super, quasi-normal, and sub diffusion), and very slowly aging. Moreover, we show that the diffusion tensor elements (including off-diagonal elements; i.e. odd diffusion coefficient) change sign according to the flow vorticity value. Therefore, the chiral fluid appears to have a self regulated diffusive behavior, controlled by chiral vorticity.
Group size varies with climate and oceanographic conditions in bottlenose dolphins
Authors: Methion Séverine , Paradell Oriol Giralt , Padín Xosé Antonio , Corrège Thierry , López Bruno Díaz
Published: April 2022

The authors have requested that this preprint be removed from Research Square.
Job burnout, depression and anxiety symptoms: the mediating role of psychological capital among 969 managers in eastern China
Authors: Jiang Zhaoqiang , Jiang Huiquan , Jin Mingying , Chen Junqiang , Lin Guomin , Chen Junfei , Feng Lingfang , Xia Hailing , Li Yongxin , Xu Huadong , Liu Shuang , Lou Jianlin , Ni Zhe
Published: April 2022

Objectives: Psychological capital plays an important role in the improvement of mental health. However, the mediating role of psychological capital between job burnout and mental problems has rarely been addressed. This study aims to explore the association between burnout and anxiety and depression symptoms, and the mediating role of psychological capital in this association among managers in eastern China. Methods: A total of 969 managers were recruited to complete a structured questionnaire consisting of items from demographic characteristics, job burnout, anxiety, to depression symptoms using the Maslach Burnout Inventory-General Survey, Generalized Anxiety Disorder Scale, Patient Health Questionnaire-9, and psychological capital scale. The associations between burnout, psychological capital, depression, and anxiety symptoms using multivariate linear regression models. The significance of the mediation effect was calculated using the Sobel test.Results: A total of 969 participants were recruited. The average scores of burnout, psychological capital, depression, and anxiety symptoms were (36.6±14.9), (4.7±0.7), (5.0±4.5), and (6.1±4.9), respectively. Job burnout was positively associated with depression and anxiety symptoms (P < 0.001), and negatively associated with psychological capital (r = -0.46, P < 0.001). Psychological capital mediated the association between job burnout and depression symptoms (P = 0.02). Conclusions: Our findings contribute to the understanding the mediating role of psychological capital in the association between job burnout and depression. Interventions are needed to improve positive psychological capital for the management of the burnout and mental problems among managers.
Rotating Behind Security: An enhanced authentication protocol for IoT-enabled devides in distributed cloud computing architecture
Authors: Wu Tsu-Yang , Kong Fangfang , Meng Qian , Kumari Saru , Chen Chien-Ming
Published: April 2022

As Internet of Things (IoT) technology continues to advance, IoT devices have permeated every part of life. The emergence of cloud computing has become a key technology for solving the memory limitation problem of IoT devices, greatly promoting resource sharing, facilitating user access to information at any time, and providing IoT services. However, IoT message is transferred over public channels and is therefore accessible to attacks in the IoT-based cloud computing environment, resulting in user and server privacy leakage. To solve this issue, Amin et al. proposed an authentication protocol for use in this environment. However, Kang et al. proved that their protocol had many security vulnerabilities and proposed an improved authentication protocol. Recently, Huang et al. found security vulnerabilities in Kang et al.’s protocol and designed an enhanced protocol of their own. In this article, we first demonstrate that Huang et al.’s enhanced protocol is vulnerable to privileged insider attacks and temporary value leakage attacks. Then, based on their protocol an enhanced authentication protocol is proposed for IoT-enabled devices in a distributed cloud computing architecture. Finally, security analysis and performance comparisons are conducted, showing that our protocol has both greater security and better performance.