bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience in endoscope choice for neuroendoscopic lavage for intraventricular hemorrhage of prematurity: a systematic review
Authors: Wassef Catherine E. , Thomale Ulrich W. , LoPresti Melissa A. , DeCuypere Michael G. , Raskin Jeffrey S. , Mukherjee Shreya , Aquilina Kristian , Lam Sandi K.
Published: May 2024

Objective

Intraventricular hemorrhage (IVH) of prematurity occurs in 20–38% of infants born < 28 weeks gestational age and 15% of infants born in 28–32 weeks gestational age. Treatment has evolved from conservative management and CSF diversion of temporizing and shunting procedures to include strategies aimed at primarily clearing intraventricular blood products. Neuroendoscopic lavage (NEL) aims to decrease the intraventricular blood burden under the same anesthetic as temporizing CSF diversion measures in cases of hydrocephalus from IVH of prematurity. Given the variety of neuroendoscopes, we sought to review the literature and practical considerations to help guide neuroendoscope selection when planning NEL.

Methods

We conducted a systematic review of the literature on neuroendoscopic lavage in IVH of prematurity to examine data on the choice of neuroendoscope and outcomes regarding shunt rate. We then collected manufacturer data on neuroendoscopic devices, including inflow and outflow mechanisms, working channel specifications, and tools compatible with the working channel. We paired this information with the advantages and disadvantages reported in the literature and observations from the experiences of pediatric neurosurgeons from several institutions to provide a pragmatic evaluation of international clinical experience with each neuroendoscope in NEL.

Results

Eight studies were identified; four neuroendoscopes have been used for NEL as reported in the literature. These include the Karl Storz Flexible Neuroendoscope, LOTTA® system, GAAB system, and Aesculap MINOP® system. The LOTTA® and MINOP® systems were similar in setup and instrument options. Positive neuroendoscope features for NEL include increased degrees of visualization, better visualization with the evolution of light and camera sources, the ability to sterilize with autoclave processes, balanced inflow and outflow mechanisms via separate channels, and a working channel. Neuroendoscope disadvantages for NEL may include special sterilization requirements, large outer diameter, and limitations in working channels.

Conclusions

A neuroendoscope integrating continuous irrigation, characterized by measured inflow and outflow via separate channels and multiple associated instruments, appears to be the most commonly used technology in the literature. As neuroendoscopes evolve, maximizing clear visualization, adequate inflow, measured outflow, and large enough working channels for paired instrumentation while minimizing the footprint of the outer diameter will be most advantageous when applied for NEL in premature infants.
Clinical characteristics and hearing loss etiology of cochlear implantees undergoing surgery in their teens, 20s, and 30s
Authors: Choe Goun , Lim Jong Woo , Chun Ye Jun , Han Jin Hee , Kim Bong Jik , Choi Byung Yoon
Published: May 2024

Purpose

This study aimed to investigate the etiology of hearing loss, including genetic variants, in individuals who underwent cochlear implantation (CI) in their teens to thirties. It also sought to analyze post-CI speech performance and identify prognostic factors affecting CI outcomes in this age group.

Methods

We conducted a retrospective review of 421 cochlear implant patients at Seoul National University Bundang Hospital, focusing on 63 subjects aged 10–39 years who underwent their first CI by a single surgeon between July 2018 and June 2022. The study included audiologic evaluation, molecular genetic testing, and analysis of speech performance post-CI. Statistical analyses were performed using SPSS 25 and GraphPad Prism 7.

Results

Among 63 participants (M:F, 24:39), nine underwent CI in their teens, 24 in their 20 s, and 30 in their 30 s. Most of them (40, 63.5%) had postlingual deafness. The study found that 65.2% (40/63) of subjects received a genetic diagnosis, with DFNB4 being the most common etiology (37.5%, 15/40). Post-CI speech evaluation showed an average sentence score of 80% across all subjects. Factors such as the onset of hearing loss, duration of deafness (DoD), and preoperative Speech Intelligibility Rating (SIR) significantly influenced CI outcomes. Notably, longer DoD was associated with poorer CI outcomes, but this did not affect individuals with postlingual hearing loss as much.

Conclusion

The study concludes that in individuals aged 10–39 undergoing CI, the onset of hearing loss and preoperative SIR are critical predictors of postoperative outcomes. CI is recommended for those with postlingual hearing loss in this age group, irrespective of the DoD. The study highlights the importance of genetic factors especially DFNB4 in hearing loss etiology and underscores the value of the relatively easy-to-evaluate factor, preoperative SIR in predicting CI outcomes.
Effect of elevated temperature and hydrocortisone addition on the proliferation of fibroblasts
Authors: Pavlikova Zuzana , Zahradnicek Oldrich , Jelinek Michaelidesova Anna , Sramek Jaromir , Davidkova Marie , Hovorakova Maria
Published: May 2024

Hyperthermia along with hydrocortisone (HC) are proven teratogens that can negatively influence embryo development during early pregnancy. Proliferation of cells is one of the main developmental processes during the early embryogenesis. This study was focused on testing the effect of elevated temperature and HC addition on proliferation of cells in in vitro cultures. The V79-4 cell line was treated with HC and cultured in vitro at 37 °C or 39 °C, respectively. To reveal the effect of both factors, the proliferation of cells cultured under different conditions was evaluated using various approaches (colony formation assay, generation of growth curves, computation of doubling times, and mitotic index estimation). Our results indicate that a short-term exposure to elevated temperature slightly stimulates and a long-term exposure suppresses cell proliferation. However, HC (0.1 mg/ml) acts as a stimulator of cell proliferation. Interestingly, the interaction of HC and long-term elevated temperature (39 °C) exposure results in at least partial compensation of the negative impact of elevated temperature by HC addition and in higher proliferation if compared with cells cultured at 39 °C without addition of HC.
Outpatient Surgery and Unplanned Overnight Admission in Bilateral Inguinal Hernia Repair: A Population-based Study
Authors: Hidalgo Nils Jimmy , Guillaumes Salvador , Llompart-Coll M. Magdalena , González-Atienza Paula , Bachero Irene , Momblán Dulce , Vidal Óscar
Published: May 2024

Purpose

The use of outpatient surgery in inguinal hernia is heterogeneous despite clinical recommendations. This study aimed to analyze the utilization trend of outpatient surgery for bilateral inguinal hernia repair (BHIR) in Spain and identify the factors associated with outpatient surgery choice and unplanned overnight admission.

Methods

A retrospective observational study of patients undergoing BIHR from 2016 to 2021 was conducted. The clinical-administrative database of the Spanish Ministry of Health RAE-CMBD was used. Patient characteristics undergoing outpatient and inpatient surgery were compared. A multivariable logistic regression analysis was performed to identify factors associated with outpatient surgery choice and unplanned overnight admission.

Results

A total of 30,940 RHIBs were performed; 63% were inpatient surgery, and 37% were outpatient surgery. The rate of outpatient surgery increased from 30% in 2016 to 41% in 2021 (p < 0.001). Higher rates of outpatient surgery were observed across hospitals with a higher number of cases per year (p < 0.001). Factors associated with outpatient surgery choice were: age under 65 years (OR: 2.01, 95% CI: 1.92–2.11), hospital volume (OR: 1.59, 95% CI: 1.47–1.72), primary hernia (OR: 1.89, 95% CI: 1.71–2.08), and laparoscopic surgery (OR: 1.47, 95% CI: 1.39–1.56). Comorbidities were negatively associated with outpatient surgery. Open surgery was associated (OR: 1.26, 95% CI: 1.09–1.47) with unplanned overnight admission.

Conclusions

Outpatient surgery for BHIR has increased in recent years but is still low. Older age and comorbidities were associated with lower rates of outpatient surgery. However, the laparoscopic repair was associated with increased outpatient surgery and lower unplanned overnight admission.
Variability of joint hypermobility in children: a meta-analytic approach to set cut-off scores
Authors: Williams Cylie M. , Welch James J. , Scheper Mark , Tofts Louise , Pacey Verity
Published: May 2024

Current international consensus of the appropriate Beighton score cut-off to define if a child has generalised joint hypermobile or not is based upon expert opinion. Our aim was to determine the prevalence of Beighton scores of children worldwide to provide a recommendation for establishing the Beighton score cut-off to identify generalised joint hypermobility in children. We used AMED, OVID Medline, Embase and CINAHL to find published articles from inception to April 2024 describing Beighton scores of children up to and including 18 years from the general population. We extracted study demographics including country of publication, total number of participants, summary data about the age and sex of participant, Beighton scores and any cut-off used where authors deemed children hypermobile and how many children were rated at the corresponding Beighton scores. There were 37 articles reporting on the prevalence or incidence of hypermobility at cut-off scores from 28,868 participants. Using the cut-off of ≥ 6 resulted in a prevalence of 6% for studies reporting male data and 13% for studies reporting female data. Limited data reporting availability precluded further sub-analysis at a Beighton score of ≥ 7, age, pubertal status and ethnicity.

    Conclusion: The working threshold for identifying generalised joint hypermobility in children should be a Beighton score of 6 or more. Our analysis also suggests a Beighton score of 7 or greater may be appropriate in childhood, particularly for females.

What is Known:• The working threshold for identifying generalised joint hypermobility in children previously was set based on expert opinion.

What is New:• The threshold to identify hypermobility in children should be at a minimum of ≥ 6 on the Beighton score.
Treatment of endometrial cancer from 2000 to 2020 in Germany: a retrospective population based cohort study
Authors: Papathemelis Thomas , Ortmann Olaf , Kohl Cynthia , Neuser Petra , Tol Kees Kleihues-van , Klinkhammer-Schalke Monika , Ugocsai Peter , Walter Christina Barbara , Rottmann Miriam , Real Catherine , Justenhoven Christina , Robers Gabriele , Schneider Constanze , Gerken Michael , Sackmann Andrea , Kim-Wanner Soo-Zin
Published: May 2024

Purpose

Endometrial cancer (EC) is one of the most common malignancies among women in western countries. This study aimed to assess data on patient treatment in Germany throughout two decades to evaluate the development and effect of surgery, radiation, and chemotherapy.

Methods

This retrospective registry study included 34,349 EC patients diagnosed between 2000 and 2020. Patients were classified into five risk groups. Overall survival was analyzed by Kaplan–Meier method as well as univariable and multivariable Cox regression to evaluate risk factors and treatment options.

Results

Over the study period, minimal invasive surgery was used more often compared to open surgery and was associated with better overall survival. Patients with advanced EC were more likely to receive multimodal therapy.

Patients with intermediate risk EC had a good prognosis upon surgery, which further improved when radiotherapy was added. High-risk patients showed poorer prognosis but clearly benefited from additional radiotherapy. Survival of elderly high-risk patients with a non-endometrioid histology was improved when chemotherapy was added to surgery and radiotherapy.

Conclusion

Our study includes a large analysis of data from German clinical cancer registries on the care of endometrial cancer during two decades. We observed an increase of minimal invasive surgery. There is evidence that minimal invasive surgery is not inferior to open surgery. Adjuvant radio- and chemotherapy further improves survival depending on risk group and age.
Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer
Authors: Luo Yuanyuan , Mao Dongmei , Zhang Le , Yang Zhihui , Miao Jingxia , Zhang Lili
Published: May 2024

Purpose

To identify symptom clusters (SCs) in patients with lung cancer who are undergoing initial chemotherapy and to identify the sentinel symptoms of each SC.

Methods

A convenience sampling method was used to recruit patients with lung cancer who were undergoing their initial chemotherapy treatment. Patient information was collected using the General Demographic Questionnaire, MD Anderson Symptom Inventory (including the lung cancer module) and a schedule documenting the initial occurrence of symptoms. The Walktrap algorithm was employed to identify SCs, while sentinel symptoms within each SC were identified using the Apriori algorithm in conjunction with the initial occurrence time of symptoms.

Results

A total of 169 patients with lung cancer participated in this study, and four SCs were identified: the psychological SC (difficulty remembering, sadness, dry mouth, numbness or tingling, and distress), somatic SC (pain, fatigue, sleep disturbance, and drowsiness), respiratory SC (coughing, expectoration, chest tightness, and shortness of breath), and digestive SC (nausea, poor appetite, constipation, vomiting, and weight loss). Sadness, fatigue, and coughing were identified as sentinel symptoms of the psychological, somatic, and respiratory SCs, respectively. However, no sentinel symptom was identified for the digestive SC.

Conclusion

Patients with lung cancer who are undergoing chemotherapy encounter a spectrum of symptoms, often presenting as SCs. The sentinel symptom of each SC emerges earlier than the other symptoms and is characterized by its sensitivity, significance, and driving force. It serves as a vital indicator of the SC and assumes a sentry role. Targeting sentinel symptoms might be a promising strategy for determining the optimal timing of interventions and for mitigating or decelerating the progression of the other symptoms within the SC.
Changes in vessel density patterns assessed with OCTA in patients with diabetic macular edema treated with anti-VEGF therapy
Authors: Santamaría Juan , Cobos Estefanía , Biarnes Marc , Caminal Josep María , Rodriguez-Leor Ramon , Morwani Rahul , García-Mendieta Manel , Lorenzo Daniel , García-Bru Pere , Arias Luis
Published: May 2024

Aims

To determine the presence of sectoral changes in vessel density (VD) patterns induced by vascular endothelial growth factor inhibitors (anti-VEGF) in patients with diabetic macular edema (DME) using optical coherence tomography angiography (OCTA).

Methods

Prospective, interventional study. A total of 43 patients (63 eyes) were initially enrolled in the study. We performed swept source (SS) OCT and sectorial OCTA measurement to determine parafoveal VD at baseline and after six months of anti-VEGF treatment. In the locations with statistically significant differences in VD between baseline and month 6, we performed univariate and multivariate analyses to determine which, if any, of the baseline variables were associated with the observed changes.

Results

A total of 34 patients (48 eyes) were included in the final analysis. Mean VD decreased from baseline to month 6 (from 45.2 (± 3.5) to 44.6 (± 3.2) % in the SCP and from 50 (± 3.3) to 49 (± 3.9) % in the DCP). The only significant changes in VD were observed in the nasal sector of the deep capillary plexus, with a decrease of 2.9% (p = 0.001). On univariate and multivariate analyses, the only variable significantly associated with changes in VD in the nasal sector after 6 months of treatment was baseline VD in the same sector.

Conclusions

Anti-VEGF therapy has a small impact on VD values over time. These variations observed after treatment seems to be related to changes over areas of vascular anomalies and displaced vessels adjacent to cystic areas, with no significant changes over ischemic areas. No correlation was observed between this trend and other clinical baseline features.
Cultivating empathy through narratives in virtual reality: a review
Authors: Hadjipanayi Christos , Christofi Maria , Banakou Domna , Michael-Grigoriou Despina
Published: May 2024

In recent years, there has been a growing interest in the potential of virtual reality (VR) as a powerful tool for storytelling and as a means of promoting empathy. This systematic review examines 20 research papers that were deemed relevant based on inclusion and exclusion criteria from a database of a total of 661 papers to investigate the use of VR for empathy-building through immersive storytelling. Thematic analysis of the interventions revealed that most of the narratives focused on the experiences of victims of abuse, social minorities, and individuals affected by medical conditions or political ramifications. These fall under three types of digital narratives identified as (a) personal, (b) historical, and (c) educational. Changes in empathy are identified either through comparisons with non-VR narratives or pre- and post-interventions. Interaction techniques, VR affordances, and methods to measure empathy are further identified. The review concludes that while VR shows promise as a tool for promoting empathy, more research is needed to fully understand its potential and limitations.
The perception of the scope of oral and maxillofacial surgery and differentiation from similar specialities among dental students, medical students, trainee interns and pre-vocational junior doctors
Authors: Mane Robert , Sharpe-Davidson William Fox , De Silva Harsha , Choi Joanne Jung Eun
Published: May 2024

Purpose

To explore the ability of Dental Students (DS), Medical Students (MS), Trainee Interns (TI) and Pre-vocational Junior Doctors (JD) in identifying procedures performed by Oral and Maxillofacial Surgery (OMS), the scope of practice (SOP) of OMS and ability to differentiate OMS from similar specialities.

Methods

The study included 282 complete responses to a survey consisting of: 9 demographic questions, 11 OMS awareness, professional ambition, teaching and exposure, confidence in identifying and referring questions and 70 procedural/scenario questions across four domains. Collected data was qualitatively and statistically analysed using SPSS V29.

Results

OMS awareness was limited. 92.2% reported None to Small amount of OMS teaching and exposure during university, with 66.0% preferring to have had a Fair to Significant amount. DS experienced more than medical respondents (2.1 vs. 1.5, p < 0.001). Most respondents reported No to Low confidence in identifying the SOP and procedures performed by OMS (67.7%) and referring to OMS (62.4%) compared to similar specialities (32.4% and 33.2%, respectively). 52.9% of procedures performed by OMS were correctly identified as being performed by OMS. The ability to identify the OMS SOP (8.7%) and differentiate OMS from similar specialities (5.0%) was low, however better among DS than medical respondents (14.9% vs. 6.3%, p = 0.002 and 12.2% vs. 2.2%, p < 0.001).

Conclusion

The study has highlighted a deficit in the understanding of OMS with potential implications in the public and private healthcare sector. Identification of procedures, OMS SOP and ability to differentiate OMS from similar specialities is limited however slightly better among DS.
A verified low-level implementation and visualization of the adaptive exterior light and speed control system
Authors: Krings Sebastian , Körner Philipp , Dunkelau Jannik , Rutenkolk Kristin
Published: May 2024

In this article, we present an approach to the ABZ 2020 case study that differs from those usually presented at ABZ: Rather than using a (correct-by-construction) approach following a formal method, we use C for a low-level implementation instead. We strictly adhere to test-driven development for validation, and only afterwards apply model checking using CBMC for verification. While the approach has several benefits compared to the more rigorous approaches, it also provides less mathematical clarity and overall less thorough verification. In consequence, our realization of the ABZ case study serves as a baseline reference for comparison, allowing to assess the benefit provided by the various formal modeling languages, methods and tools.
Head-locked, world-locked, or conformal diminished-reality? An examination of different AR solutions for pedestrian safety in occluded scenarios
Authors: Peereboom Joris , Tabone Wilbert , Dodou Dimitra , de Winter Joost
Published: May 2024

Many collisions between pedestrians and cars are caused by poor visibility, such as occlusion by a parked vehicle. Augmented reality (AR) could help to prevent this problem, but it is unknown to what extent the augmented information needs to be embedded into the world. In this virtual reality experiment with a head-mounted display (HMD), 28 participants were exposed to AR designs, in a scenario where a vehicle approached from behind a parked vehicle. The experimental conditions included a head-locked live video feed of the occluded region, meaning it was fixed in a specific location within the view of the HMD (VideoHead), a world-locked video feed displayed across the street (VideoStreet), and two conformal diminished reality designs: a see-through display on the occluding vehicle (VideoSeeThrough) and a solution where the occluding vehicle has been made semi-transparent (TransparentVehicle). ABaselinecondition without augmented information served as a reference. Additionally, theVideoHeadandVideoStreetconditions were each tested with and without the addition of a guiding arrow indicating the location of the approaching vehicle. Participants performed 42 trials, 6 per condition, during which they had to hold a key when they felt safe to cross. The keypress percentages and responses from additional questionnaires showed that the diminished-realityTransparentVehicleandVideoSeeThroughdesigns came out most favourably, while theVideoHeadsolution caused some discomfort and dissatisfaction. An analysis of head yaw angle showed thatVideoHeadandVideoStreetcaused divided attention between the screen and the approaching vehicle. The use of guiding arrows did not contribute demonstrable added value. AR designs with a high level of local embeddedness are beneficial for addressing occlusion problems when crossing. However, the head-locked solutions should not be immediately dismissed because, according to the literature, such solutions can serve tasks where a salient warning or instruction is beneficial.
Automated classification of choroidal neovascularization, diabetic macular edema, and drusen from retinal OCT images using vision transformers: a comparative study
Authors: Akça Said , Garip Zeynep , Ekinci Ekin , Atban Furkan
Published: May 2024

Classifying retinal diseases is a complex problem because the early problematic areas of retinal disorders are quite small and conservative. In recent years, Transformer architectures have been successfully applied to solve various retinal related health problems. Age-related macular degeneration (AMD) and diabetic macular edema (DME), two prevalent retinal diseases, can cause partial or total blindness. Diseases therefore require an early and accurate detection. In this study, we proposed Vision Transformer (ViT), Tokens-To-Token Vision Transformer (T2T-ViT) and Mobile Vision Transformer (Mobile-ViT) algorithms to detect choroidal neovascularization (CNV), drusen, and diabetic macular edema (DME), and normal using optical coherence tomography (OCT) images. The predictive accuracies of ViT, T2T-ViT and Mobile-ViT achieved on the dataset for the classification of OCT images are 95.14%, 96.07% and 99.17% respectively. Experimental results obtained from ViT approaches showed that Mobile-ViT have superior performance with regard to classification accuracy in comparison with the others. Overall, it has been observed that ViT architectures have the capacity to classify with high accuracy in the diagnosis of retinal diseases.
Geochemical Characterization of an AMD-Affected Stream: Detection of Associated Trace Metal Contamination Using Element ‘Dilution Factors’
Authors: Abrahams Jamie-Leigh Robin , Carranza Emmanuel John Muico
Published: May 2024

This study characterized metal contamination in the Blesbokspruit River waters, near the coal-mining town of Emalahleni in Mpumalanga, South Africa, using enrichment factors (EFs) and contamination factors (CFs). We investigated the potential of Fe and Al ‘dilution factors’ (stream water divided by overbank sediment concentrations) under base flow hydrological conditions to detect AMD-related trace metal contamination in the study site. Waters of the Blesbokspruit River were characterized by acidic (< 3) to near neutral (≈7) pH, high EC (up to 2240 µS/cm), high sulfate (up to 1530 mg/L), ultra-high degrees of Fe contamination and minor to moderately severe enrichment of trace metals, all of which strongly indicate that the river is affected by AMD. Fe and Al dilution factors showed moderate to strong positive correlations with dissolved trace metals (Co, Ni, Zn, Pb, Cr, and Cd), but not with Cu, which is likely more associated with kaolinite in the study area. In addition, correlation analysis showed that dilution factors were better for detecting aqueous Co and Cd, and comparable for detecting aqueous Ni, relative to stream pH and aqueous Fe and Al. Dilution factors have an advantage over stream pH and aqueous Al and Fe because, once calculated, they can be used to monitor AMD-related trace metal contamination in streams during dry seasons by using only Al and Fe content in sediments. This can be beneficial when preservation methods or storage necessary for water samples are not available. However, the robustness of dilution factors during wet seasons requires further investigation.
Recht und Governance von In-vitro-Fleisch – insbesondere zur EU-Novel-Food-Verordnung
Authors: Heyl Katharine , Ekardt Felix
Published: May 2024

Globale Klima- und Biodiversitätsziele verlangen eine drastische Reduktion der Nutztierhaltung. Die neben pflanzlicher Nahrung damit in den Blick rückenden Fleischersatzprodukte wie In-vitro-Fleisch werfen einige bisher kaum diskutierte Rechts- und Steuerungsfragen auf. Einige wichtige davon erörtert der vorliegende kurze Beitrag mit Schwerpunkt auf die EU-Novel-Food-Verordnung.
Comprehensive analysis of digital twins in smart cities: a 4200-paper bibliometric study
Authors: El-Agamy Rasha F. , Sayed Hanaa A. , AL Akhatatneh Arwa M. , Aljohani Mansourah , Elhosseini Mostafa
Published: May 2024

This survey paper comprehensively reviews Digital Twin (DT) technology, a virtual representation of a physical object or system, pivotal in Smart Cities for enhanced urban management. It explores DT's integration with Machine Learning for predictive analysis, IoT for real-time data, and its significant role in Smart City development. Addressing the gap in existing literature, this survey analyzes over 4,220 articles from the Web of Science, focusing on unique aspects like datasets, platforms, and performance metrics. Unlike other studies in the field, this research paper distinguishes itself through its comprehensive and bibliometric approach, analyzing over 4,220 articles and focusing on unique aspects like datasets, platforms, and performance metrics. This approach offers an unparalleled depth of analysis, enhancing the understanding of Digital Twin technology in Smart City development and setting a new benchmark in scholarly research in this domain. The study systematically identifies emerging trends and thematic topics, utilizing tools like VOSviewer for data visualization. Key findings include publication trends, prolific authors, and thematic clusters in research. The paper highlights the importance of DT in various urban applications, discusses challenges and limitations, and presents case studies showcasing successful implementations. Distinguishing from prior studies, it offers detailed insights into emerging trends, future research directions, and the evolving role of policy and governance in DT development, thereby making a substantial contribution to the field.
Effective interpretable learning for large-scale categorical data
Authors: Zhang Yishuo , Zaidi Nayyar , Zhou Jiahui , Wang Tao , Li Gang
Published: May 2024

Large scale categorical datasets are ubiquitous in machine learning and the success of most deployed machine learning models rely on how effectively the features are engineered. For large-scale datasets, parametric methods are generally used, among which three strategies for feature engineering are quite common. The first strategy focuses on managing the breadth (or width) of a network, e.g., generalized linear models (aka. ). The second strategy focuses on the depth of a network, e.g., Artificial Neural networks or (aka. ). The third strategy relies on factorizing the interaction terms, e.g., Factorization Machines (aka. ). Each of these strategies brings its own advantages and disadvantages. Recently, it has been shown that for categorical data, combination of various strategies leads to excellent results. For example,  -Learning, , etc., leads to state-of-the-art results. Following the trend, in this work, we have proposed another learning framework—-Learning, based on the combination of , , , and a newly introduced component named  (). is in the form of a Bayesian network classifier whose structure is learned apriori, and parameters are learned by optimizing a joint objective function along with , and  parts. We denote the learning of  parameters as . Additionally, the parameters of  are constrained to be actual probabilities—therefore, it is extremely interpretable. Furthermore, one can sample or generate data from , which can facilitate learning and provides a framework for knowledge-guided machine learning. We demonstrate that our proposed framework possesses the resilience to maintain excellent classification performance when confronted with biased datasets. We evaluate the efficacy of our framework in terms of classification performance on various benchmark large-scale categorical datasets and compare against state-of-the-art methods. It is shown that, framework (a) exhibits superior performance on classification tasks, (b) boasts outstanding interpretability and (c) demonstrates exceptional resilience and effectiveness in scenarios involving skewed distributions.
Spontaneous focusing on numerical order and numerical skills of 3- to 4-year-old children
Authors: Harju Heidi , Van Hoof Jo , Nanu Cristina E. , McMullen Jake , Hannula-Sormunen Minna
Published: May 2024

Recent studies have highlighted the importance of ordinality skills in early numerical development. Here, we investigate individual differences in ordering sets of items and suggest that children might also differ in their tendency to spontaneously recognize and use numerical order in everyday situations. This study investigated the individual differences in 3- to 4-year-old children’s tendency to spontaneously focus on numerical order (SFONO), and their association with early numerical skills. One hundred fifty children were presented with three SFONO tasks designed as play-like activities, where numerical order was one aspect that could be focused on. In addition, the children were administered tasks addressing spontaneous focusing on numerosity (SFON), numerical ordering, cardinality recognition, and number sequence production. Our results showed that children had substantial individual differences in all measures, including SFONO tendency. Children’s SFONO tendency was associated with their early numerical skills. To further investigate the association between SFONO tendency and numerical ordering skills, a hierarchical regression was conducted for a group of children who could successfully order sets from one to three at a minimum and were regarded as likely having the requisite skills to spontaneously focus on numerical order. The findings reveal that SFONO tendency had a unique contribution to children’s numerical ordering skills, even after controlling for age, cardinality recognition, and number sequence production. The results suggest that SFONO tendency potentially plays a relevant role in children’s numerical development.
The non-linear impact of monetary policy on shifts in economic policy uncertainty: evidence from the United States of America
Authors: Dima Bogdan , Dima Ștefana Maria
Published: May 2024

A stochastic volatility estimation of VIX index’s latent volatility is used for the United States of America, as a proxy for the adjustments in the levels of investors’ uncertainty related to current and future economic policies. The impact of monetary policy stance on such measure is examined in the framework of the distributed lag non-linear models (DLNM). We place this analysis in the literature stream emphasizing the various sources of heterogeneity concerning investors’ expectations. The main finding is that the monetary policy does impact non-linearly the adjustments in investors’ predictions. While a tighter monetary policy does generally contribute to an increase in VIX’s latent volatility, the shape of such effect varies across different GLM and GAM specifications of DLNM. This outcome remains robust, even if: (1) we control for the global price of Brent crude and consumers’ confidence; (2) we use, instead of the stochastic framework, a Markov-switching GARCH-based estimator; or (3) we replace the monetary policy instrument with monetary policy uncertainty. We argue that accounting for its nonlinear effects on financial markets is of critical importance for the design of a monetary policy pursuing global financial stability.
Testing the Labeling Effect in Autistic Children
Authors: Parrillas-Manchón Sergio , Castroviejo Elena , Hernández-Conde José V. , Rodríguez-Armendariz Ekaine , Vicente Agustín
Published: May 2024

Purpose

Our objective was to test the labeling effect in autistic children. The effect has been robustly tested in typically developing (TD) individuals. TD children expect that any two objects that receive the same linguistic label will have similar properties, which suggests that they generate concepts based on acts of labeling. The labeling effect has not been tested on autistic children, who may not be equally attuned to the relevance of linguistic clues or may not generalize as swiftly as TD children.

Methods

We reproduced Graham et al.,’s (Frontiers in Psychology 10.3389/fpsyg.2012.00586, 2013) design on 30 autistic children of different ages. Participants were divided into two groups depending on whether objects presented to them were named alike or differently (Same or Distinct Label between-individuals condition). The dependent variable was the number of target actions the child performed on an object, depending on whether that object made the same sound as a previously shown test object.

Results

We did not reproduce results similar to those reported in Graham et al., (Frontiers in Psychology 10.3389/fpsyg.2012.00586, 2013). Children in the Same Label group did not perform significantly more actions than children in the Distinct Label group when the objects that were handed to the children did not make the same sound as the test object.

Conclusions

Autistic children do not seem to be sensitive to the labeling effect to the same extent as TD children. If these results are confirmed, intervention programs for autistic children should consider trainings on this way of generating concepts shared by their linguistic community.
Introduced mammalian predators influence demography and trait variation of a New Zealand stag beetle
Authors: Grey L. , Trewick S. A. , Johnson S. L.
Published: May 2024

Most species co-evolve with their predators and develop strategies to avoid predation. This is not possible when a novel predator invades an environment. Native residents must quickly adapt to their new predator or face local extinction. Intense competition for mating opportunities exerts significant selective pressure that can drive the evolution of exaggerated structures across taxa. However, these elaborate traits can elevate the risk of predation for some organisms. In the present study, we observe the effect that rats have had on a population of endemic New Zealand stag beetles, Geodorcus helmsi. Rats in Rakiura | Stewart Island often prey on stag beetles, taking them to a sheltered area to eat them and discard any uneaten parts of the beetle, namely the head and mandibles. We compared the head size, mandible size and numbers of predated and non-predated male and female beetles in three sites in Rakiura | Stewart Island that differ in their abundance of mammalian predators. We found that the population demography and the size of the beetles differed significantly between sites. Additionally, we determined whether predated beetles were larger than non-predated beetles, across multiple years, regardless of site. We found that overall the predated specimens were larger than the non-predated beetles. The trends found here suggest that exaggeration of the male mandibles increases the predation risk of these iconic beetles, acting as a limit to mandible size.

Implications for insect conservation

Our results show for the first time the effect that novel predators can have on a population of animals with exaggerated sexually selected traits. The presence of novel predators can cause a shift in both population demography and trait distribution.
Impact of aluminium doping in magnesium-doped zinc oxide thin films by sputtering for photovoltaic applications
Authors: Rahman Mirza Mustafizur , Rahman Kazi Sajedur , Rokonuzzaman Md. , Bhari Bibi Zulaika , Ludin Norasikin Ahmad , Ibrahim Mohd Adib
Published: May 2024

In this study, Mg-doped zinc oxide (MZO) thin films were deposited through radio frequency (RF) sputtering for different substrate temperatures ranging from room temperature (25 °C) to 350 °C. XRD analysis depicted that the higher substrate temperatures lead to increased crystallite size. From the UV–Vis spectroscopy, transmittance (T) was found approximately 95% and the optical band energy gap (Eg) was determined around 3.70 eV. Hall effect measurement system measured the carrier concentration and resistivity of all films in the order of 1014 cm−3 and 103 Ω-cm, respectively. Since the structural and optoelectrical properties of the MZO films were not significantly affected by the substrate temperatures, Aluminium (Al) was co-doped in the MZO film to improve structural and optoelectrical properties. As a result, the carrier concentration of Al doped MZO (AMZO) films was increased up to ~ 1020 cm−3 from ~ 1014 cm3 (MZO), and the resistivity was decreased up to ~ 10–1 Ω-cm from 103 Ω-cm (MZO) representing the significant changes in electrical properties without affecting the transmittance. This study opens a pathway for improving the MZO buffer layer that can enhance the cell performance of CdTe solar cells.

Graphical abstract
Behavioral state-dependent selection of roads by guanacos
Authors: Serota Mitchell W. , Alarcón Pablo A. E. , Donadio Emiliano , Middleton Arthur D.
Published: May 2024

Context

Widespread globally, roads impact the distribution of wildlife by influencing habitat use and avoidance patterns near roadways and disrupting movement across them. Wildlife responses to roads are known to vary across species; however within species, the response to roads may depend on the season or the individual’s behavioral state.

Objectives

We assess the movement behavior and space use of the most widespread large herbivore in Patagonia, the guanaco (Lama guanicoe). We estimated the preference or avoidance to paved or unpaved roads (the proximity effect) and the preference or avoidance to traverse them (the crossing effect).

Methods

Using GPS collar data, we combined Hidden Markov Models with an integrated step selection analysis to segment guanaco movement trajectories into individual behaviors and test for differences in road effects on movement.

Results

We found that guanacos display distinct movement responses to different types of roads depending on their behavioral state. Guanacos select for proximity to paved roads while foraging, but against them when traveling. Yet, guanacos select for unpaved roads when traveling. Despite the selection for proximity to paved roads, guanacos avoid crossing them, irrespective of their behavioral state.

Conclusion

Our findings offer significant implications for guanaco distribution and management across Patagonia. The selection for roads strongly influences the distribution of guanacos, which could concentrate grazing in some areas while freeing others. Despite potential benefits such as increased vegetation near roadsides, increased association with roads while foraging may result in an ecological trap. Finally, the strong aversion to crossing paved roads raises concerns about habitat loss and connectivity.
Predictors and surgical outcome of hemorrhagic metastatic brain malignancies
Authors: Rauschenbach Laurèl , Kolbe Pia , Engel Adrian , Ahmadipour Yahya , Oppong Marvin Darkwah , Santos Alejandro N. , Kebir Sied , Dobersalske Celia , Scheffler Björn , Deuschl Cornelius , Dammann Philipp , Wrede Karsten H. , Sure Ulrich , Jabbarli Ramazan
Published: May 2024

Purpose

Intracerebral metastases present a substantial risk of tumor-associated intracerebral hemorrhage (ICH). This study aimed to investigate the risk of hemorrhagic events in brain metastases (BM) from various primary tumor sites and evaluate the safety and outcomes of surgical tumor removal.

Methods

A retrospective, single-center review of medical records was conducted for patients who underwent BM removal between January 2016 and December 2017. Patients with hemorrhagic BM were compared to those with non-hemorrhagic BM. Data on preoperative predictors, perioperative management, and postoperative outcomes were collected and analyzed.

Results

A total of 229 patients met the inclusion criteria. Melanoma metastases were significantly associated with preoperative hemorrhage, even after adjusting for confounding factors (p = 0.001). Poor clinical status (p = 0.001), larger tumor volume (p = 0.020), and unfavorable prognosis (p = 0.001) independently predicted spontaneous hemorrhage. Importantly, preoperative use of anticoagulant medications was not linked to increased hemorrhagic risk (p = 0.592). Surgical removal of hemorrhagic BM, following cessation of blood-thinning medication, did not significantly affect intraoperative blood loss, surgical duration, or postoperative rebleeding risk (p > 0.096). However, intra-tumoral hemorrhage was associated with reduced overall survival (p = 0.001).

Conclusion

This study emphasizes the safety of anticoagulation in patients with BM and highlights the safety of neurosurgical treatment in patients with hemorrhagic BM when blood-thinning medication is temporarily paused. The presence of intra-tumoral hemorrhage negatively impacts survival, highlighting its prognostic significance in BM patients. Further research with larger cohorts is warranted to validate these findings and elucidate underlying mechanisms.
4E cognition, moral imagination, and engineering ethics education: shaping affordances for diverse embodied perspectives
Authors: van Grunsven Janna , Marin Lavinia , Gammon Andrea , Franssen Trijsje
Published: May 2024

While 4E approaches to cognition are increasingly introduced in educational contexts, little has been said about how 4E commitments can inform pedagogy aimed at fostering ethical competencies. Here, we evaluate a 4E-inspired ethics exercise that we developed at a technical university to enliven the moral imagination of engineering students. Our students participated in an interactive tinkering workshop, during which they materially redesigned a healthcare artifact. The aim of the workshop was twofold. Firstly, we wanted students to experience how material choices at the levels of design and functionality can enable morally significant reimaginings of the affordances commonly associated with existing artifacts. We term this type of reimagining world-directed moral imagination. Secondly, through the design process, we wanted students to robustly place themselves in the lived embodied perspectives of (potential) users of their selected artifacts. We term this person-directed moral imagination. While student testimonies about the exercise indicate that both their world-directed and person-directed moral imagination were enlivened, we note that the fostering of robust person-directed moral imagination proved challenging. Using 4E insights, we diagnose this challenge and ask how it might be overcome. To this end, we engage extensively with a recent 4E-informed critique of person-directed moral imagination, raised by Clavel Vázquez and Clavel-Vázquez (2023). They argue that person-directed moral imagination is profoundly limited, if not fundamentally misguided, particularly when exercised in contexts marked by emphatic embodied situated difference between the imaginer and the imagined. Building upon insights from both the 4E field and testimonies from critical disability studies, we argue that, while their critique is valuable, it ultimately goes too far. We conclude that a 4E approach can take on board recent 4E warnings regarding the limits of person-directed moral imagination while contributing positively to the development of moral imagination in engineering ethics education.
Composition of integral-type operators and discrete operators involving Laguerre polynomials
Authors: Abel Ulrich , Gupta Vijay
Published: May 2024

In this note we provide a new way to capture operators involving Laguerre polynomials by composition of an integral operator and a discrete operator. The new operator so obtained is a discrete operator. We give three examples by considering composition of Szász-Durrmeyer operator, exponential-type operator related to $$2x^{3/2}$$

2

x

3
/
2

and the Phillips operator, respectively, with Szász-Mirakyan operators. In all cases we obtain positive linear, discretely defined operators which are based on Laguerre polynomials and approximate functions on the positive real half-axis.