bluuebunny/crossref_metadata_2025 huggingface dataset:
Purification and Characterization of Double-Stranded Nucleic Acid-Dependent ATPase Activities of Tagged Dicer-Related Helicase 1 and its Short Isoform in Caenorhabditis elegans
Authors: Kobayashi Taishi , Murakami Takuro , Hirose Yuu , Eki Toshihiko
Published: July 2020

The Dicer-related helicases (DRHs) are members of a helicase subfamily, and mammalian DRHs such as retinoic acid-inducible gene-I (RIG-I), are involved in antiviral immunity. Caenorhabditis elegans DRH-1 and DRH-3 play crucial roles in antiviral function and chromosome segregation, respectively. Although intrinsic double-stranded RNA-dependent ATP-hydrolyzing activity has been observed in the recombinant DRH-3 protein prepared from Escherichia coli, there are no reports of biochemical studies of the nematode RIG-I homolog DRH-1. In this study, the secondary structure prediction by JPred4 revealed that DRH-1 and DRH-3 had distinct N-terminal regions and that a 200-amino acid N-terminal region of DRH-1 could form a structure very rich in α-helices. We investigated expressions and purifications of a codon-optimized DRH-1 with four different N-terminal tags, identifying poly-histidine (His)-small ubiquitin-like modifier (SUMO) as a suitable tag for DRH-1 preparation. Full-length (isoform a) and a N-terminal truncated (isoform b) of DRH-1 were purified as the His-SUMO-tagged fusion proteins. Finally, the nucleic acid-dependent ATPase activities were investigated for the two His-SUMO-tagged DRH-1 isoforms and His-tagged DRH-3. The tagged DRH-3 exhibited dsRNA-dependent ATPase activity. However, detectable dsRNA dependency of ATPase activities was not found in either isoform of tagged DRH-1 and a tag-free DRH-1 (isoform a) treated with SUMO protease. These observations suggest that DRH-1 and its short isoform have no or poor nucleic acid-dependent ATPase activity, unlike DRH-3 and mammalian DRHs.
The Zagreb (Croatia) M5.5 Earthquake on 22 March 2020
Authors: Markušić Snježana , Stanko Davor , Korbar Tvrtko , Belić Nikola , Penava Davorin , Kordić Branko
Published: July 2020

On 22 March 2020, Zagreb was struck by an M5.5 earthquake that had been expected for more than 100 years and revealed all the failures in the construction of residential buildings in the Croatian capital, especially those built in the first half of the 20th century. Because of that, extensive seismological, geological, geodetic and structural engineering surveys were conducted immediately after the main shock. This study provides descriptions of damage, specifying the building performances and their correlation with the local soil characteristics, i.e., seismic motion amplification. Co-seismic vertical ground displacement was estimated, and the most affected area is identified according to Sentinel-1 interferometric wide-swath data. Finally, preliminary 3D structural modeling of the earthquake sequence was performed, and two major faults were modeled using inverse distance weight (IDW) interpolation of the grouped hypocenters. The first-order assessment of seismic amplification (due to site conditions) in the Zagreb area for the M5.5 earthquake shows that ground motions of approximately 0.16–0.19 g were amplified at least twice. The observed co-seismic deformation (based on Sentinel-1A IW SLC images) implies an approximately 3 cm uplift of the epicentral area that covers approximately 20 km2. Based on the preliminary spatial and temporal analyses of the Zagreb 2020 earthquake sequence, the main shock and the first aftershocks evidently occurred in the subsurface of the Medvednica Mountains along a deep-seated southeast-dipping thrust fault, recognized as the primary (master) fault. The co-seismic rupture propagated along the thrust towards northwest during the first half-hour of the earthquake sequence, which can be clearly seen from the time-lapse visualization. The preliminary results strongly support one of the debated models of the active tectonic setting of the Medvednica Mountains and will contribute to a better assessment of the seismic hazard for the wider Zagreb area.
Examining the Research Evolution on the Socio-Economic and Environmental Dimensions on University Social Responsibility
Authors: Meseguer-Sánchez Víctor , Abad-Segura Emilio , Belmonte-Ureña Luis Jesús , Molina-Moreno Valentín
Published: July 2020

Responsible higher education institutions have an impact on society and economic, environmental, and social development. These effects define the axes of the socially responsible management of the universities. The concept of university social responsibility (USR) manages these relationships to produce a positive impact on society through higher education, research, and the transfer of knowledge and technology, as well as education for sustainability. For this study, worldwide research into this subject was studied for the period 1970–2019. A bibliometric analysis of 870 articles was made, obtaining results for the scientific productivity of the journals, authors, institutions, and countries contributing to this research. The main category is business, management, and accounting. The most productive journal is the Business and Society Review, while the California Management Review is the most cited. The authors with the most articles are Stavnezer, Luo, and Lanero. The most productive institution is Wuhan University. The United States is the country with the most publications and citations, and the same country, together with the United Kingdom, make the most international contributions. Evidence shows growing worldwide interest in the economic and environmental impacts of USR. Future research should focus on analysing the links between the responsible and sustainable consumption of universities and their short-term financial, economic, and sustainable impacts.
Regional Analysis of Associations between Infant and Young Child Feeding Practices and Diarrhoea in Indian Children
Authors: Dhami Mansi , Ogbo Felix , Diallo Thierno , Agho Kingsley ,   on behalf of the Global Maternal and Child Health Research Collaboration (GloMACH)
Published: July 2020

Studies on the association between infant and young child feeding (IYCF) practices and diarrhoea across regional India are limited. Hence, we examined the association between IYCF practices and diarrhoea in regional India. A weighted sample of 90,596 (North = 11,200, South = 16,469, East = 23,317, West = 11,512, Central = 24,870 and North-East = 3228) from the 2015–2016 National Family Health Survey in India was examined, using multivariate logistic regressions that adjust for clustering and sampling weights. The IYCF indicators included early initiation of breastfeeding (EIBF), exclusive breastfeeding (ExcBF), predominant breastfeeding (PBF), bottle feeding (BotF), continued breastfeeding (BF) at one-year, continued BF at two years, children ever breastfed and the introduction of solid, semi-solid or soft foods (ISSSF). Diarrhoea prevalence was lower among infants who were BF within one-hour of birth and those who were exclusively breastfed. Multivariate analyses revealed that continued BF at one and two years, and infants who were introduced to complementary foods had a higher prevalence of diarrhoea. EIBF and ExcBF were protective against diarrhoea in the regions of North, East and Central India. PBF, BotF and ISSSF were risk factors for diarrhoea in Central India. Continued BF at two years was a risk factor for diarrhoea in Western India. Findings suggested that EIBF and ExcBF were protective against diarrhoea in Northern, Eastern and Central India, while PBF, BotF, continued BF at two years and ISSSF were risk factors for diarrhoea in various regions in India. Improvements in IYCF practices are likely to reduce the burden of diarrhoea-related morbidity and mortality across regions in India.
The Effect of Prescription Drugs and Alcohol Consumption on Intimate Partner Violence Victim Blaming
Authors: Sáez Gemma , Ruiz Manuel J. , Delclós-López Gabriel , Expósito Francisca , Fernández-Artamendi Sergio
Published: July 2020

Intimate Partner Violence (IPV) is a public health problem with harsh consequences for women’s well-being. Social attitudes towards victims of IPV have a big impact on the perpetuation of this phenomenon. Moreover, specific problems such as the abuse of alcohol and drugs by IPV victims could have an effect on blame attributions towards them. The aim of this study was to evaluate whether the external perception (Study 1) and self-perception (Study 2) of blame were influenced by the victims’ use and abuse of alcohol or by the victims’ use of psychotropic prescription drugs. Results of the first study (N = 136 participants) showed a significantly higher blame attribution towards female victims with alcohol abuse compared to those without it. No significant differences were found on blame attributed to those with psychotropic prescription drugs abuse and the control group. Results of the second study (N = 195 female victims of interpersonal violence) showed that alcohol consumption is associated with higher self-blame and self-blame cognitions among IPV victims. However, results did not show significant differences on self-blame associated to the victims’ use of psychotropic prescription drugs. Our findings indicate that alcohol consumption, but not prescription drugs use, plays a relevant role in the attribution of blame by general population and self-blame by victims of IPV.
Is Narcissism Associated with Heavy Work Investment? The Moderating Role of Workload in the Relationship between Narcissism, Workaholism, and Work Engagement
Authors: Falco Alessandra , Girardi Damiano , Di Sipio Annamaria , Calvo Vincenzo , Marogna Cristina , Snir Raphael
Published: July 2020

This study aimed to investigate the association between narcissism and two forms of heavy work investment, namely, workaholism and work engagement. More specifically, it was hypothesized that narcissism is positively associated with both workaholism and work engagement, with workload moderating these relationships, which are expected to be stronger when the workload is high. Overall, 217 workers completed a self-report questionnaire, and the hypothesized relationships were tested using moderated multiple regression. Results partially supported our predictions. Narcissism was positively associated with workaholism and its dimensions of working excessively and working compulsively only in individuals facing a high workload. Furthermore, narcissism was positively associated with work engagement and its dimensions of vigor and dedication (but no absorption) in employees with average levels of workload. Finally, the workload exacerbated the relationship between narcissism and work engagement and its dimensions so that these associations were stronger when the workload was high. Overall, our study suggested that in a work environment characterized by moderate levels of demand, individuals with strong narcissistic components might inherently feel energetic and dedicated (i.e., engaged) at work. Differently, in a demanding work environment, workers with high narcissism might experience higher work engagement, but they could also be at risk of workaholism.
Correlates of Depressive Symptoms among Middle-Aged and Older Homeless Adults Using the 9-Item Patient Health Questionnaire
Authors: Wang Lin-Yun , Lin Lan-Ping , Chen Yun-Cheng , Wang Tai-Wen , Lin Jin-Ding
Published: July 2020

This study investigates the screening for depressive symptoms among middle-aged and older homeless adults based on Patient Health Questionnaire-9 (PHQ-9) and examines the possible factors associated with their major depressive symptoms. A cross-sectional survey was employed, and research subjects included 129 homeless people aged 45 years old and over in Taipei Wanhua District and Taipei Main Station. We used a structured questionnaire and face-to-face interview conducted by three social workers to collect data in the analyses. The content of the questionnaire included an informed consent form, demographic characteristics, enabling and need factors of healthcare, and PHQ-9 of homeless people. Results revealed that 15.5% respondents were free of depressive symptoms, 16.3% had mild level (score 5–9), 31.8% had moderate level (score 10–14), 26.4% had moderately severe level (score 15–19), and 10.1% had severe level of depressive symptoms (score 20–27). Adopting a PHQ-9 score 10 as a cut-off point for major depressive symptoms, 68.3% of middle-aged and older homeless adults were the cases needing to be referred to healthcare settings for further recheck in the near future. A multiple regression analysis found gender, age, and usage of psychiatric outpatient care were associated with major depressive symptom occurrence. The female participants were less likely to have major depressive symptoms than the male participants (OR = 0.29, 95% CI = 0.09–0.96). The elderly participants were more likely to have major depressive symptoms than the aged 45–54 years (OR = 5.29, 95% CI = 1.44–19.41). Those participants who have ever used psychiatric outpatient care were significantly more correlated with the occurrence of major depressive symptoms than their counterparts (OR = 3.65, 95% CI = 1.46–9.09). The present study suggests that in the future health policy should eliminate the risk factors of depressive symptoms and improve mental healthcare access, to improve the health and wellbeing of the homeless population.
Geographical and Economic Factors Affecting the Spatial Distribution of Micro, Small, and Medium Enterprises: An Empirical Study of The Kujawsko-Pomorskie Region in Poland
Authors: Chłoń-Domińczak Agnieszka , Fiedukowicz Anna , Olszewski Robert
Published: July 2020

Micro, small, and medium-sized enterprises (MSMEs) are an essential part of economies at the national, regional, and local levels. Understanding the determinants of the development of this sector is interesting not only for researchers but also for local governments to support the development of this sector. This paper analyses micro, small, and medium enterprises at the gmina (local) level in one region, the Kujawsko-Pomorskie voivodship (NUTS2) in Poland. The authors use multivariate linear regression, spatial econometrics, and classification trees to model the influence of different factors on the number of enterprises relative to population size. The authors found that the most crucial factor in all cases, independently of the method used, is the local government’s revenue from personal income tax per capita. This finding, together with the lack of significance of variables related to the distance to technological parks or economic zones, indicates that the enterprises in the region produce mainly for local consumption and lack innovativeness. The authors also examined the influence of spatial context on the number of enterprises. The most important factor seems to be the percentage of built-up areas, but there are also others, depending on the model type; again, this confirms the local character of the activity of micro, small, and medium enterprises in the region. Variables representing the spatial context can explain the relative number of enterprises with coefficient of determination (R2) between 0.30 and 0.45, which shows that this context played a relatively significant role in the development of the MSME sector in the region. On the other hand, the econometric models (that include the neighborhood) are only significant (improving R2) for medium enterprises, which means that medium enterprises expand their activity beyond the local range.
A Soybean bZIP Transcription Factor GmbZIP19 Confers Multiple Biotic and Abiotic Stress Responses in Plant
Authors: He Qing , Cai Hanyang , Bai Mengyan , Zhang Man , Chen Fangqian , Huang Youmei , Priyadarshani S. V. G. N. , Chai Mengnan , Liu Liping , Liu Yanhui , Chen Huihuang , Qin Yuan
Published: July 2020

The basic leucine zipper (bZIP) is a plant-specific transcription factor family that plays crucial roles in response to biotic and abiotic stresses. However, little is known about the function of bZIP genes in soybean. In this study, we isolated a bZIP gene, GmbZIP19, from soybean. A subcellular localization study of GmbZIP19 revealed its nucleus localization. We showed that GmbZIP19 expression was significantly induced by ABA (abscisic acid), JA (jasmonic acid) and SA (salicylic acid), but reduced under salt and drought stress conditions. Further, GmbZIP19 overexpression Arabidopsis lines showed increased resistance to S. sclerotiorum and Pseudomonas syringae associated with upregulated ABA-, JA-, ETH- (ethephon-)and SA-induced marker genes expression, but exhibited sensitivity to salt and drought stresses in association with destroyed stomatal closure and downregulated the salt and drought stresses marker genes’ expression. We generated a soybean transient GmbZIP19 overexpression line, performed a Chromatin immunoprecipitation assay and found that GmbZIP19 bound to promoters of ABA-, JA-, ETH-, and SA-induced marker genes in soybean. The yeast one-hybrid verified the combination. The current study suggested that GmbZIP19 is a positive regulator of pathogen resistance and a negative regulator of salt and drought stress tolerance.
Detection of Genomic Regions Associated with Resistance to Stem Rust in Russian Spring Wheat Varieties and Breeding Germplasm
Authors: Leonova Irina N. , Skolotneva Ekaterina S. , Orlova Elena A. , Orlovskaya Olga A. , Salina Elena A.
Published: July 2020

Stem rust caused by Puccinia graminis f. sp. tritici Eriks. is a dangerous disease of common wheat worldwide. Development and cultivation of the varieties with genetic resistance is one of the most effective and environmentally important ways for protection of wheat against fungal pathogens. Field phytopathological screening and genome-wide association study (GWAS) were used for assessment of the genetic diversity of a collection of spring wheat genotypes on stem rust resistance loci. The collection consisting of Russian varieties of spring wheat and introgression lines with alien genetic materials was evaluated over three seasons (2016, 2017 and 2018) for resistance to the native population of stem rust specific to the West Siberian region of Russia. The results indicate that most varieties displayed from moderate to high levels of susceptibility to P. graminis; 16% of genotypes had resistance or immune response. In total, 13,006 single-nucleotide polymorphism (SNP) markers obtained from the Infinium 15K array were used to perform genome-wide association analysis. GWAS detected 35 significant marker-trait associations (MTAs) with SNPs located on chromosomes 1A, 2A, 2B, 3B, 5A, 5B, 6A, 7A and 7B. The most significant associations were found on chromosomes 7A and 6A where known resistance genes Sr25 and Sr6Ai = 2 originated from Thinopyrum ssp. are located. Common wheat lines containing introgressed fragments from Triticum timopheevii and Triticum kiharae were found to carry Sr36 gene on 2B chromosome. It has been suggested that the quantitative trait loci (QTL) mapped to the chromosome 5BL may be new loci inherited from the T. timopheevii. It can be inferred that a number of Russian wheat varieties may contain the Sr17 gene, which does not currently provide effective protection against pathogen. This is the first report describing the results of analysis of the genetic factors conferring resistance of Russian spring wheat varieties to stem rust.
Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro
Authors: Raunio Hannu , Pentikäinen Olli , Juvonen Risto O.
Published: July 2020

in vivo methods, such as spectrophotometric, fluorometric, mass spectrometric,and radioactivity-based techniques. In fluorescence-based assays, the reaction produces a fluorescentproduct from a nonfluorescent substrate or vice versa. Fluorescence-based enzyme assays areusually highly sensitive and specific, allowing measurements on small specimens of tissues withlow enzyme activities. Fluorescence assays are also amenable to miniaturization of the reactionmixtures and can thus be done in high throughput. 7-Hydroxycoumarin and its derivatives arewidely used as fluorophores due to their desirable photophysical properties. They possess a large -conjugated system with electron-rich and charge transfer properties. This conjugated structure leadsto applications of 7-hydroxycoumarins as fluorescent sensors for biological activities. We describe inthis review historical highlights and current use of coumarins and their derivatives in evaluatingactivities of the major types of xenobiotic-metabolizing enzyme systems. Traditionally, coumarinsubstrates have been used to measure oxidative activities of cytochrome P450 (CYP) enzymes. For thispurpose, profluorescent coumarins are very sensitive, but generally lack selectivity for individual CYPforms. With the aid of molecular modeling, we have recently described several new coumarin-basedsubstrates for measuring activities of CYP and conjugating enzymes with improved selectivity.
Stearoyl-CoA Desaturase-1 Attenuates the High Shear Force Damage Effect on Human MG63 Osteosarcoma Cells
Authors: Huang Kuo-Chin , Chuang Po-Yao , Hsieh Rong-Ze , Chen Cheng-Nan , Chang Shun-Fu , Su Yu-Ping
Published: July 2020

Mechanical regulation is known as an important regulator in cancer progression and malignancy. High shear force has been found to inhibit the cell cycle progression and result in cell death in various cancer cells. Stearoyl-CoA desaturase (SCD)-1, one of the important lipogenic enzymes, has recently been indicated as a potential pharmaceutical target in cancer therapy. In this study, we determined whether the cell fate control of shear force stimulation is through regulating the SCD-1 expression in cancer cells. Human MG63 osteosarcoma cells were used in this study. 2 and 20 dynes/cm2 shear forces were defined as low and high intensities, respectively. A SCD-1 upregulation in human MG63 osteosarcoma cells under 20, but not 2, dynes/cm2 shear force stimulation was shown, and this induction was regulated by Smad1/5 and peroxisome proliferator-activated receptor δ (PPARδ) signaling. Moreover, gene knockdown of PPARδ and SCD-1 in human MG63 osteosarcoma cells attenuated the differentiation inhibition and resulted in much more cell death of high shear force initiation. The present study finds a possible auto-protective role of SCD-1 upregulation in high shear force-damaged human MG63 osteosarcoma cells. However, its detailed regulation in the cancer fate decision of high shear force should be further examined.
Diagnostic and Therapeutic Management of Upper Extremity Deep Vein Thrombosis
Authors: Bosch Floris T. M. , Nisio Marcello Di , Büller Harry R. , van Es Nick
Published: July 2020

Upper extremity deep vein thrombosis (UEDVT) accounts for 5% of all deep vein thromboses (DVTs). UEDVT may be complicated by post thrombotic syndrome and pulmonary embolism, and early recognition and prompt start of anticoagulant treatment are key. Primary UEDVT, also known as Paget-von Schrötter syndrome, is associated with repeated or sudden physical activity of the upper arm and venous outflow obstruction due to anatomical variations. Secondary UEDVT is often associated with malignancy or use of intravenous devices, such as central venous catheters or pacemaker leads. Although the diagnosis and treatment of UEDVT have many similarities with DVT of the lower extremities, knowledge of specific aspects regarding UEDVT is important to guide optimal management. In this review, we will discuss the epidemiology, diagnosis, and treatment of UEDVT based on the current literature.
Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals
Authors: Weber Daniela , Kochlik Bastian , Stuetz Wolfgang , Dollé Martijn E. T. , Jansen Eugène H. J. M. , Grubeck-Loebenstein Beatrix , Debacq-Chainiaux Florence , Bernhardt Jürgen , Gonos Efstathios S. , Capri Miriam , Franceschi Claudio , Sikora Ewa , Moreno-Villanueva María , Bürkle Alexander , Grune Tilman
Published: July 2020

The regular use of medication may interfere with micronutrient metabolism on several levels, such as absorption, turnover rate, and tissue distribution, and this might be amplified during aging. This study evaluates the impact of self-reported medication intake on plasma micronutrients in the MARK-AGE Project, a cross-sectional observational study in 2217 subjects (age- and sex-stratified) aged 35–75 years from six European countries that were grouped according to age. Polypharmacy as possible determinant of micronutrient concentrations was assessed using multiple linear regression models adjusted for age-group, dietary fruit, vegetables, and juice intake, and other confounders. Younger participants reported taking fewer drugs than older participants. Inverse associations between medication intake and lutein (−3.31% difference per increase in medication group), β-carotene (−11.44%), α-carotene (−8.50%) and positive associations with retinol (+2.26%), α-tocopherol/cholesterol (+2.89%) and γ-tocopherol/cholesterol (+1.36%) occurred in multiple adjusted regression models. Combined usage of a higher number of medical drugs was associated with poorer status of carotenoids on the one hand and higher plasma concentrations of retinol, α- and γ-tocopherol on the other hand. Our results raise concerns regarding the safety of drug combinations via the significant and surprisingly multifaceted disturbance of the concentrations of relevant micronutrients.
Elongation Patterns of the Posterior Cruciate Ligament after Total Knee Arthroplasty
Authors: Hosseini Nasab Seyyed Hamed , Smith Colin , Schütz Pascal , Postolka Barbara , Ferguson Stephen , Taylor William R. , List Renate
Published: July 2020

This study aimed to understand the ability of fixed-bearing posterior cruciate ligament (PCL)-retaining implants to maintain functionality of the PCL in vivo. To achieve this, elongation of the PCL was examined in six subjects with good clinical and functional outcomes using 3D kinematics reconstructed from video-fluoroscopy, together with multibody modelling of the knee. Here, length-change patterns of the ligament bundles were tracked throughout complete cycles of level walking and stair descent. Throughout both activities, elongation of the anterolateral bundle exhibited a flexion-dependent pattern with more stretching during swing than stance phase (e.g., at 40° flexion, anterolateral bundle experienced 3.9% strain during stance and 9.1% during swing phase of stair descent). The posteromedial bundle remained shorter than its reference length (defined at heel strike of the level gait cycle) during both activities. Compared with loading patterns of the healthy ligament, postoperative elongation patterns indicate a slackening of the ligament at early flexion followed by peak ligament lengths at considerably smaller flexion angles. The reported data provide a novel insight into in vivo PCL function during activities of daily living that has not been captured previously. The findings support previous investigations reporting difficulties in achieving a balanced tension in the retained PCL.
Intensive Motion Style Acupuncture Treatment (MSAT) Is Effective for Patients with Acute Whiplash Injury: A Randomized Controlled Trial
Authors: Kim Doori , Park Kyoung-Sun , Lee Jin-Ho , Ryu Won-Hyung , Moon Heeyoung , Park Jiwon , Jeon Yong-Hyun , Seo Ji-Yeon , Moon Young-Joo , Namgoong Jin , Shin Byung-Cheul , Ha In-Hyuk
Published: July 2020

In this single-center, parallel, randomized controlled trial, we aim to examine the effects and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) on pain reduction and functional improvement in patients with whiplash-associated disorders (WADs). Ninety-seven patients with cervical pain admitted to the Bucheon Jaseng Hospital of Korean Medicine, South Korea, due to acute whiplash injury were treated with integrative Korean medicine (IKM) with (MSAT group, 48 patients) or without (control group, 49 patients) an additional 3-day MSAT during hospitalization (5–14 days) and followed-up for 90 days. The mean numeric rating scale (NRS) scores of the MSAT and control groups at baseline were 5.67 (95% confidence interval (CI), 5.33, 6.01) and 5.44 (95% CI, 5.06, 5.82), respectively, and on day 5, 3.55 (95% CI, 3.04, 4.06) and 4.59 (95% CI, 4.10–5.07), respectively. The NRS change difference between the groups was −1.07 (95% CI, −1.76, −0.37). The rate of recovery of neck pain (NRS score change ≥ 2 points) was significantly faster in the MSAT than in the control group (log-rank test p = 0.0055). IKM treatment combined with MSAT may be effective in reducing the pain and improving the range of motion in patients with WADs.
From Closed to Claimed Spaces for Participation: Contestation in Urban Redevelopment Induced-Displacements and Resettlement in Kigali, Rwanda
Authors: Nikuze Alice , Sliuzas Richard , Flacke Johannes
Published: July 2020

In many cities and urban areas in Africa, land acquisition for urban redevelopment, land readjustment, and resettlement of affected urban residents are currently framed as innovative approaches to eradicating informal settlements, improving the living environments, and supporting the implementation of newly adopted city Master Plans. Nevertheless, it is not yet known how the responses of institutions and affected people shape these processes. Based on research conducted in Kigali, Rwanda, this article discusses affected residents’ responses to land expropriation and resettlement necessary for urban redevelopments. Our findings show that affected informal settlement dwellers voiced their concerns over the deviations from the Expropriation Law, compensation decision-making made behind closed doors, lack of transparency in property valuation, and compensation packages that they perceive to be unfair. Some of the consequences of these concerns are strong feelings of unfairness, exclusion, and marginalisation; distrust and increased perceptions of impoverishment risks, all of which fuel contestation and resistance attitudes among the affected landowners. The affected landowners agitate to assert their rights and stake their claims through contestations, community mobilisation, and legal recourse. We conclude that such contestations constitute claimed spaces and interactions in which affected landowners are laying claim to fair processes against the ‘’exceptionality’’ and the “decide-defend” decision-making approaches, while local authorities assert legitimacy of their decisions. Critically, informal households affected by urban redevelopments see opportunities for participation in their resettlement decision-making as fundamental to securing their future.
Zr(OH)4/GO Nanocomposite for the Degradation of Nerve Agent Soman (GD) in High-Humidity Environments
Authors: Jang Seongon , Ka Dongwon , Jung Hyunsook , Kim Min-Kun , Jung Heesoo , Jin Youngho
Published: July 2020

Zirconium hydroxide, Zr(OH)4 is known to be highly effective for the degradation of chemical nerve agents. Due to the strong interaction force between Zr(OH)4 and the adsorbed water, however, Zr(OH)4 rapidly loses its activity for nerve agents under high-humidity environments, limiting real-world applications. Here, we report a nanocomposite material of Zr(OH)4 and graphene oxide (GO) which showed enhanced stability in humid environments. Zr(OH)4/GO nanocomposite was prepared via a dropwise method, resulting in a well-dispersed and embedded GO in Zr(OH)4 nanocomposite. The nitrogen (N2) isotherm analysis showed that the pore structure of Zr(OH)4/GO nanocomposite is heterogeneous, and its meso-porosity increased from 0.050 to 0.251 cm3/g, compared with pristine Zr(OH)4 prepared. Notably, the composite material showed a better performance for nerve agent soman (GD) degradation hydrolysis under high-humidity air conditions (80% relative humidity) and even in aqueous solution. The soman (GD) degradation by the nanocomposite follows the catalytic reaction with a first-order half-life of 60 min. Water adsorption isotherm analysis and diffuse reflectance infrared Fourier transform (DRIFT) spectra provide direct evidence that the interaction between Zr(OH)4 and the adsorbed water is reduced in Zr(OH)4/GO nanocomposite, indicating that the active sites of Zr(OH)4 for the soman (GD) degradation, such as surface hydroxyl groups are almost available even in high-humidity environments.
Physical and Technical Foundations of the Use of Alternating Free Bending for Producing Long-length Semi-products from Metals and Alloys with Improved Mechanical Properties
Authors: Raab Georgy , Utyashev Farid , Asfandiyarov Rashid , Raab Arseniy , Aksenov Denis , Kodirov Ilyas , Janeček Miloš , Krajňák Tomáš
Published: July 2020

In this work, we give a theoretical justification of the non-monotonic character of strain in the process of refinement and formation of a grain-type structure during the deformation processing of low-alloyed copper heat-hardenable alloys. A regularity is revealed, suggesting the alternating behavior of the strain state in the process of the continuous bending of billets. It is found that the continuous free bending process in the conditions of multi-cycle (four cycles) processing increases the strength and produces a gradient-type structure and a gradient of mechanical properties. Using fabrication of the experimental samples of the contact wire as an example, it is shown that the obtained results can serve as a scientific and technical foundation for the development of complex methods for the processing of axis-symmetrical long-length objects from copper heat-hardenable alloys in the form of wires and shaped products with improved mechanical properties, with potential adaptability for manufacturing.
Influence of Genetic Processes on Geochemistry of Fe-oxy-hydroxides in Supergene Zn Non-Sulfide Deposits
Authors: Santoro Licia , Putzolu Francesco , Mondillo Nicola , Boni Maria , Herrington Richard
Published: July 2020

In supergene Zn non-sulfide deposits, the Fe-oxy-hydroxides (FeO/OH) are mainly concentrated in the residual zones (gossan) on top of the oxidized ore bodies, although they can also be found throughout the whole weathering profile coexisting with the primary and secondary ore assemblages. Fe-oxy-hydroxides are rarely pure as they form in systems where a wide range of metals, most of them of economic importance (e.g., Zn, Pb, Co, REE, Sc, Ga, Ge, V, etc.), freely circulate and can be “captured” under specific conditions. Although their occurrence can be widespread, and they have a potential to scavenge and accumulate critical metals, FeO/OH are considered gangue phases during the existing processing routes of Zn non-sulfide ores. Moreover, very little is known about the role of the deposit type on the geochemistry of FeO/OH formed in a specific association. Therefore, this paper provides a comprehensive assessment of the trace element footprint of FeO/OH from a number of Zn non-sulfide deposits, in order to define parameters controlling the metals’ enrichment process in the mineral phase. To achieve this, we selected FeO/OH-bearing mineralized samples from four supergene Zn non-sulfide ores in diverse settings, namely Hakkari (Turkey), Jabali (Yemen), Cristal (Peru) and Kabwe (Zambia). The petrography of FeO/OH was investigated by means of scanning electron microscope energy dispersive analysis (SEM-EDS), while the trace element composition was assessed using laser ablation-ICP-MS (LA-ICP-MS). Statistical analyses performed on LA-ICP-MS data defined several interelement associations, which can be ascribed to the different nature of the studied deposits, the dominant ore-formation process and subsequent evolution of the deposits and the environmental conditions under which FeO/OH phases were formed. Based on our results, the main new inferences are: (A) Zinc, Si, Pb, Ga and Ge enrichment in FeO/OH is favored in ores where the direct replacement of sulfides is the dominant process and/or where the pyrite is abundant (e.g., Cristal and Hakkari). (B) When the dissolution of the host-rock is a key process during the supergene ore formation (i.e., Jabali), the buffering toward basic pH of the solutions favors the uptake in FeO/OH of elements leached from the host carbonate rock (i.e., Mn), whilst restricting the uptake of elements derived from the dissolution of sulfides (i.e., Zn, Pb, Ga and Ge), as well as silica. (C) The input of exotic phases can produce significant enrichment in “unconventional” metals in FeO/OH (i.e., Cr and Co at Kabwe; Y at Cristal) depending on whether the optimal pH-Eh conditions are attained. (D) In the Kabwe deposit, FeO/OH records heterogeneous geochemical conditions within the system: where locally basic conditions prevailed during the alteration process, the V and U concentration in FeO/OH is favored; yet conversely, more acidic weathering produced Zn- and Si-bearing FeO/OH.
A Core Flood and Microfluidics Investigation of Nanocellulose as a Chemical Additive to Water Flooding for EOR
Authors: Aadland Reidun C. , Akarri Salem , Heggset Ellinor B. , Syverud Kristin , Torsæter Ole
Published: July 2020

Cellulose nanocrystals (CNCs) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (T-CNFs) were tested as enhanced oil recovery (EOR) agents through core floods and microfluidic experiments. Both particles were mixed with low salinity water (LSW). The core floods were grouped into three parts based on the research objectives. In Part 1, secondary core flood using CNCs was compared to regular water flooding at fixed conditions, by reusing the same core plug to maintain the same pore structure. CNCs produced 5.8% of original oil in place (OOIP) more oil than LSW. For Part 2, the effect of injection scheme, temperature, and rock wettability was investigated using CNCs. The same trend was observed for the secondary floods, with CNCs performing better than their parallel experiment using LSW. Furthermore, the particles seemed to perform better under mixed-wet conditions. Additional oil (2.9–15.7% of OOIP) was produced when CNCs were injected as a tertiary EOR agent, with more incremental oil produced at high temperature. In the final part, the effect of particle type was studied. T-CNFs produced significantly more oil compared to CNCs. However, the injection of T-CNF particles resulted in a steep increase in pressure, which never stabilized. Furthermore, a filter cake was observed at the core face after the experiment was completed. Microfluidic experiments showed that both T-CNF and CNC nanofluids led to a better sweep efficiency compared to low salinity water flooding. T-CNF particles showed the ability to enhance the oil recovery by breaking up events and reducing the trapping efficiency of the porous medium. A higher flow rate resulted in lower oil recovery factors and higher remaining oil connectivity. Contact angle and interfacial tension measurements were conducted to understand the oil recovery mechanisms. CNCs altered the interfacial tension the most, while T-CNFs had the largest effect on the contact angle. However, the changes were not significant enough for them to be considered primary EOR mechanisms.
The Development of a Psychometrically Valid and Reliable Questionnaire to Assess Nutrition Knowledge Related to Pre-Schoolers
Authors: Rapson Jeanette , Conlon Cathryn , Beck Kathryn , von Hurst Pamela , Ali Ajmol
Published: July 2020

With rising childcare enrollments, caregivers have a unique opportunity to promote children’s nutrition education and healthy eating. Accurately identifying nutrition knowledge gaps amongst caregivers is necessary for professional development planning. Our aim was to design an early childhood education and care (ECEC) teacher nutrition knowledge questionnaire that satisfies psychometric criteria of validity and reliability. Items were based on the New Zealand Ministry of Health dietary guidelines, literature and expert advice. University students in their final year of a Bachelor of Science (BSc) in Human Nutrition (n = 40), and students with no nutrition background (n = 51) completed the questionnaire to assess construct validity; 35 BSc nutrition students completed the questionnaire two weeks later to assess reliability. The Mann-Whitney-U test and a median-split table assessed construct validity; Pearson’s product-moment correlation assessed test-retest reliability. Nutrition students achieved higher total and subcategory scores (p < 0.01). All nutrition students scored above the median of the combined group; 82% of non-nutrition students scored below the median. In testing reliability, first and second administration median scores for total and subcategories were significantly correlated (r = 0.43–0.78; p < 0.01). The questionnaire achieved construct validity and test-retest reliability and measured ECEC teachers’ nutrition knowledge for preschoolers.
Identification of Quantitative Trait Loci Relating to Flowering Time, Flag Leaf and Awn Characteristics in a Novel Triticum dicoccum Mapping Population
Authors: Wright Tally I.C. , Burnett Angela C. , Griffiths Howard , Kadner Maxime , Powell James S. , Oliveira Hugo R. , Leigh Fiona J.
Published: July 2020

Tetraploid landraces of wheat harbour genetic diversity that could be introgressed into modern bread wheat with the aid of marker-assisted selection to address the genetic diversity bottleneck in the breeding genepool. A novel bi-parental Triticum turgidum ssp. dicoccum Schrank mapping population was created from a cross between two landrace accessions differing for multiple physiological traits. The population was phenotyped for traits hypothesised to be proxies for characteristics associated with improved photosynthesis or drought tolerance, including flowering time, awn length, flag leaf length and width, and stomatal and trichome density. The mapping individuals and parents were genotyped with the 35K Wheat Breeders’ single nucleotide polymorphism (SNP) array. A genetic linkage map was constructed from 104 F4 individuals, consisting of 2066 SNPs with a total length of 3295 cM and an average spacing of 1.6 cM. Using the population, 10 quantitative trait loci (QTLs) for five traits were identified in two years of trials. Three consistent QTLs were identified over both trials for awn length, flowering time and flag leaf width, on chromosomes 4A, 7B and 5B, respectively. The awn length and flowering time QTLs correspond with the major loci Hd and Vrn-B3, respectively. The identified marker-trait associations could be developed for marker-assisted selection, to aid the introgression of diversity from a tetraploid source into modern wheat for potential physiological trait improvement.
Internal Residual Strain Measurements in Carbon Fiber-Reinforced Polymer Laminates Curing Process Using Embedded Tilted Fiber Bragg Grating Sensor
Authors: Ma Ke-Ping , Wu Chao-Wei , Tsai Yao-Tung , Hsu Ya-Chun , Chiang Chia-Chin
Published: July 2020

Carbon fiber reinforced plastics (CFRP) have many mechanical properties that are superior to those of conventional structural materials and are becoming more and more widely used. Monitoring the curing process used to produce such composite material is important to ensure the quality of the process, especially for the characterization of residual strains after the material has been manufactured. In this study, we present a tilted fiber Bragg grating (TFBG) sensor used to monitor the curing of CFRP composite materials. The TFBG sensor was embedded into the layers of CFRP laminates to study the curing residual strain of the laminates. The experimental results showed that the curing residual stress was about −22.25 MPa, the axial residual strain was −281.351 με, and lateral residual strain of 89.91 με. The TFBG sensor was found to be sensitive to the curing residual strain of the CFRP, meaning that it has potential for use in applications involving composite curing processes. Moreover, it is indeed possible to improve the properties of composite materials via the optimization and monitoring of their curing parameters.
Preparation and Characterization of Furan–Matrix Composites Blended with Modified Hollow Glass Microsphere
Authors: Ma Yizhe , Du Ying , Zhao Jin , Yuan Xubo , Hou Xin
Published: July 2020

In this study, a new class of thermal insulation composites was prepared by blending a modified hollow glass microsphere (HGM) with furan resin. The particle dispersion between the microparticles and resin matrix was improved using 3-methacryloxypropyltrimethoxy silane (KH-570). Furthermore, the structure and morphology of the modified HGM were characterised by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). In addition, the effects of the modified HGM on the thermal insulation, flame retardancy, and thermal properties of the composites were investigated. The thermal conductivity of the composites was lower than that of the native furan resin. The minimum thermal conductivity of the composites was 0.0274 W/m·K; the flame retardancy of the composites improved, and the limiting oxygen index become a maximum of 31.6%, reaching the refractory material level. Furthermore, the thermal analysis of the composites demonstrated enhanced thermal stability. This study demonstrates that the composite material exhibited good thermal insulation performance and flame retardancy and that it can be applied in the field of thermal insulation.
On the Impacts of Pre-Heated Natural Gas Injection in Blast Furnaces
Authors: Okosun Tyamo , Nielson Samuel , D’Alessio John , Ray Shamik , Street Stuart , Zhou Chenn
Published: July 2020

During recent years, there has been great interest in exploring the potential for high-rate natural gas (NG) injection in North American blast furnaces (BFs) due to the fuel’s relatively low cost, operational advantages, and reduced carbon footprint. However, it is well documented that increasing NG injection rates results in declining raceway flame temperatures (a quenching effect on the furnace, so to speak), with the end result of a functional limit on the maximum injection rate that can be used while maintaining stable operation. Computational fluid dynamics (CFD) models of the BF raceway and shaft regions developed by Purdue University Northwest’s (PNW) Center for Innovation through Visualization and Simulation (CIVS) have been applied to simulate multi-phase reacting flow in industry blast furnaces with the aim of exploring the use of pre-heated NG as a method of widening the BF operating window. Simulations predicted that pre-heated NG injection could increase the flow of sensible heat into the BF and promote complete gas combustion through increased injection velocity and improved turbulent mixing. Modeling also indicated that the quenching effects of a 15% increase in NG injection rate could be countered by a 300K NG pre-heat. This scenario maintained furnace raceway flame temperatures and top gas temperatures at levels similar to those observed in baseline (stable) operation, while reducing coke rate by 6.3%.