bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Environmental Life Cycle Assessment of the Combustion of Ammonia/Methane Fuels in a Tangential Swirl Burner
Authors: Razon Luis F. , Valera-Medina Agustin
Published: April 2021

Ammonia has been proposed as a replacement for fossil fuels. Like hydrogen, emissions from the combustion of ammonia are carbon-free. Unlike hydrogen, ammonia is more energy dense, less explosive, and there exists extensive experience in its distribution. However, ammonia has a low flame speed and combustion emits nitrogen oxides. Ammonia is produced via the Haber-Bosch process which consumes large amounts of fossil fuels and requires high temperatures and pressures. A life cycle assessment to determine potential environmental advantages and disadvantages of using ammonia is necessary. In this work, emissions data from experiments with generating heat from tangential swirl burners using ammonia cofired with methane employing currently available technologies were utilized to estimate the environmental impacts that may be expected. Seven ammonia sources were combined with two methane sources to create 14 scenarios. The impacts from these 14 scenarios were compared to those expected from using pure methane. The results show that using ammonia from present-day commercial production methods will result in worse global warming potentials than using methane to generate the same amount of heat. Only two scenarios, methane from biogas combined with ammonia from hydrogen from electricity and nuclear power via electrolysis and subsequent ammonia synthesis using nitrogen from the air, showed reductions in global warming potential. Subsequent analysis of other environmental impacts for these two scenarios showed potentially lower impacts for respiratory organics, terrestrial acidification-nutrification and aquatic acidification depending on how the burner is operated. The other eight environmental impacts were worse than the methane scenario because of activities intrinsic to the generation of electricity via wind power and nuclear fission. The results show that generating heat from a tangential swirl burner using ammonia currently available technologies will not necessarily result in improved environmental benefits in all categories. Improvements in renewable energy technologies could change these results positively. Other means of producing ammonia and improved means of converting ammonia to energy must continue to be explored.
Methanol-Driven Oxidative Rearrangement of Biogenic Furans – Enzyme Cascades vs. Photobiocatalysis
Authors: Jäger Christina , Bruneau Cloé , Wagner Philip K. , Prechtl Martin H. G. , Deska Jan
Published: April 2021

The oxidative ring expansion of bio-derived furfuryl alcohols to densely functionalized six-membered O-heterocycles represents an attractive strategy in the growing network of valorization routes to synthetic building blocks out of the lignocellulosic biorefinery feed. In this study, two scenarios for the biocatalytic Achmatowicz-type rearrangement using methanol as terminal sacrificial reagent have been evaluated, comparing multienzymatic cascade designs with a photo-bio-coupled activation pathway.
A Tumor Microenvironment Responsive Nanotheranostics Agent for Magnetic Resonance Imaging and Synergistic Photodynamic Therapy/Photothermal Therapy of Liver Cancer
Authors: Zhu Yuwan , Deng Mo , Xu Nannan , Xie Yingjun , Zhang Xuewen
Published: April 2021

Surgery is the main treatment for liver cancer in clinic owing to its low sensitivity to chemotherapy and radiotherapy, but this results in high mortality, recurrence, and metastasis rates. It is a feasible strategy to construct tumor microenvironments activated by nanotheranostics agents for the diagnosis and therapy of liver cancer. This study reports on a nanotheranostic agent (MONs@PDA-ICG) with manganese oxide nanoflowers (MONs) as core and polydopamine (PDA) as shell loading, with ICG as a photosensitizer and photothermal agent. MONs@PDA-ICG can not only produce ROS to kill cancer cells but also exhibit good photothermal performance for photothermal therapy (PTT). Importantly, O2 generated by MONs decomposition can relieve the tumor hypoxia and further enhance the treatment effects of photodynamic therapy (PDT). In addition, the released Mn2+ ions make MONs@PDA-ICG serve as tumor microenvironments responsive to MRI contrast for highly sensitive and specific liver cancer diagnosis.
Fabrication of Nanostructured Cadmium Selenide Thin Films for Optoelectronics Applications
Authors: Hussain Shahnwaz , Iqbal Mazhar , Khan Ayaz Arif , Khan Muhammad Nasir , Mehboob Ghazanfar , Ajmal Sohaib , Ashfaq J. M. , Mehboob Gohar , Ahmed M. Shafiq , Khisro Said Nasir , Li Chang-Jiu , Chikwenze Raphael , Ezugwu Sabastine
Published: April 2021

There is lot of research work at enhancing the performance of energy conversion and energy storage devices such as solar cells, supercapacitors, and batteries. In this regard, the low bandgap and a high absorption coefficient of CdSe thin films in the visible region, as well as, the low electrical resistivity make them ideal for the next generation of chalcogenide-based photovoltaic and electrochemical energy storage devices. Here, we present the properties of CdSe thin films synthesized at temperatures (below 100°C using readily available precursors) that are reproducible, efficient and economical. The samples were characterized using XRD, FTIR, RBS, UV-vis spectroscopy. Annealed samples showed crystalline cubic structure along (111) preferential direction with the grain size of the nanostructures increasing from 2.23 to 4.13 nm with increasing annealing temperatures. The optical properties of the samples indicate a small shift in the bandgap energy, from 2.20 to 2.12 eV with a decreasing deposition temperature. The band gap is suitably located in the visible solar energy region, which make these CdSe thin films ideal for solar energy harvesting. It also has potential to be used in electrochemical energy storage applications.
Transcription Factors Interplay Orchestrates the Immune-Metabolic Response of Leishmania Infected Macrophages
Authors: Bichiou Haifa , Bouabid Cyrine , Rabhi Imen , Guizani-Tabbane Lamia
Published: April 2021

Leishmaniasis is a group of heterogenous diseases considered as an important public health problem in several countries. This neglected disease is caused by over 20 parasite species of the protozoa belonging to the Leishmania genus and is spread by the bite of a female phlebotomine sandfly. Depending on the parasite specie and the immune status of the patient, leishmaniasis can present a wide spectrum of clinical manifestations. As an obligate intracellular parasite, Leishmania colonize phagocytic cells, mainly the macrophages that orchestrate the host immune response and determine the fate of the infection. Once inside macrophages, Leishmania triggers different signaling pathways that regulate the immune and metabolic response of the host cells. Various transcription factors regulate such immune-metabolic responses and the associated leishmanicidal and inflammatory reaction against the invading parasite. In this review, we will highlight the most important transcription factors involved in these responses, their interactions and their impact on the establishment and the progression of the immune response along with their effect on the physiopathology of the disease.
Gas Hydrates as a Means for Biogas and Biomethane Distribution
Authors: Moghaddam Elham Ahmadi , Larsolle Anders , Tidåker Pernilla , Nordberg Åke
Published: April 2021

Biomethane is receiving great attention as a renewable energy gas with lower environmental impacts and diversified sources of production. However, availability of gas infrastructure is an important factor in biomethane development and use. Biomethane can be distributed by the natural gas or local biogas grid. Biomethane can also be road-transported as compressed biomethane (CBG) or liquefied bio-methane (LBG). Biomethane could be distributed via gas hydration technology, where methane molecules are physically trapped within the crystalline structures of frozen host water molecules as gas hydrate compounds. Using life cycle assessment methodology, this study compared the energy performance and climate impact of two gas hydrate scenarios, biogas hydrate and biomethane hydrate, with that of a base case distributing biomethane as CBG. The technical system, from biogas upgrading, hydration, compression and road transport to filling station of biomethane as CBG, was included in the analysis. Results of this study show that distribution of biomethane as gas hydrates had a lower energy performance and higher climate impact than compressed biomethane distribution. The low energy performance was due to high electricity demand in hydrate formation and dissociation processes. The gas hydrate scenarios also had higher climate impacts as a result of high methane losses from hydrate formation and dissociationdissociation and emissions related to energy source use. Biogas upgrading to biomethane also significantly contributed to methane losses and climate impact of the scenarios studied.
The Shape of Species Abundance Distributions Across Spatial Scales
Authors: Antão Laura H. , Magurran Anne E. , Dornelas Maria
Published: April 2021

Species abundance distributions (SADs) describe community structure and are a key component of biodiversity theory and research. Although different distributions have been proposed to represent SADs at different scales, a systematic empirical assessment of how SAD shape varies across wide scale gradients is lacking. Here, we examined 11 empirical large-scale datasets for a wide range of taxa and used maximum likelihood methods to compare the fit of the logseries, lognormal, and multimodal (i.e., with multiple modes of abundance) models to SADs across a scale gradient spanning several orders of magnitude. Overall, there was a higher prevalence of multimodality for larger spatial extents, whereas the logseries was exclusively selected as best fit for smaller areas. For many communities the shape of the SAD at the largest spatial extent (either lognormal or multimodal) was conserved across the scale gradient, despite steep declines in area and taxonomic diversity sampled. Additionally, SAD shape was affected by species richness, but we did not detect a systematic effect of the total number of individuals. Our results reveal clear departures from the predictions of two major macroecological theories of biodiversity for SAD shape. Specifically, neither the Neutral Theory of Biodiversity (NTB) nor the Maximum Entropy Theory of Ecology (METE) are able to accommodate the variability in SAD shape we encountered. This is highlighted by the inadequacy of the logseries distribution at larger scales, contrary to predictions of the NTB, and by departures from METE expectation across scales. Importantly, neither theory accounts for multiple modes in SADs. We suggest our results are underpinned by both inter- and intraspecific spatial aggregation patterns, highlighting the importance of spatial distributions as determinants of biodiversity patterns. Critical developments for macroecological biodiversity theories remain in incorporating the effect of spatial scale, ecological heterogeneity and spatial aggregation patterns in determining SAD shape.
Identification of Hub Genes and Construction of a Transcriptional Regulatory Network Associated With Tumor Recurrence in Colorectal Cancer by Weighted Gene Co-expression Network Analysis
Authors: Liu Shengwei , Zeng Fanping , Fan Guangwen , Dong Qiyong
Published: April 2021

Tumor recurrence is one of the most important risk factors that can negatively affect the survival rate of colorectal cancer (CRC) patients. However, the key regulators dictating this process and their exact mechanisms are understudied. This study aimed to construct a gene co-expression network to predict the hub genes affecting CRC recurrence and to inspect the regulatory network of hub genes and transcription factors (TFs). A total of 177 cases from the GSE17536 dataset were analyzed via weighted gene co-expression network analysis to explore the modules related to CRC recurrence. Functional annotation of the key module genes was assessed through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. The protein and protein interaction network was then built to screen hub genes. Samples from the Cancer Genome Atlas (TCGA) were further used to validate the hub genes. Construction of a TFs-miRNAs–hub genes network was also conducted using StarBase and Cytoscape approaches. After identification and validation, a total of five genes (TIMP1, SPARCL1, MYL9, TPM2, and CNN1) were selected as hub genes. A regulatory network of TFs-miRNAs-targets with 29 TFs, 58 miRNAs, and five hub genes was instituted, including model GATA6-MIR106A-CNN1, SP4-MIR424-TPM2, SP4-MIR326-MYL9, ETS1-MIR22-TIMP1, and ETS1-MIR22-SPARCL1. In conclusion, the identification of these hub genes and the prediction of the Regulatory relationship of TFs-miRNAs-hub genes may provide a novel insight for understanding the underlying mechanism for CRC recurrence.
The Influence of the Toxin-Producing Dinoflagellate, Alexandrium catenella (1119/27), on the Survival and Reproduction of the Marine Copepod, Acartia tonsa, During Prolonged Exposure
Authors: Abdulhussain Ali H. , Cook Kathryn B. , Turner Andrew D. , Lewis Adam M. , Bibby Thomas S. , Mayor Daniel J.
Published: April 2021

Copepods can feed on, and may regulate, the blooms of harmful algae (HA), and may also facilitate dinoflagellate blooms by inducing toxin production and through selective grazing. However, exposure to HA may also cause mortality and reproductive impairment in copepods, with detrimental effects at the population-scale. Here we present the toxin profile of the dinoflagellate, Alexandrium catenella (formerly Alexandrium tamarense), and examine how it affects the survival and reproduction of the cosmopolitan marine copepod, Acartia tonsa. Healthy adult copepods were exposed to mono-specific diets of toxic and non-toxic strains of A. catenella (1119/27 and 1119/19, respectively) and non-toxic Rhodomonas sp. for 10 days alongside unfed controls to examine how their survival was influenced by likely HA bloom conditions. Additional 2-day experiments examined how their egg production rate and hatching success were affected by food deprivation, toxic A. catenella, a non-toxic alternative and a mixture of toxic and non-toxic prey, at high and low concentrations. Survival of A. tonsa declined over the 10-day experiment in all treatments but was not significantly lower in the toxic A. catenella treatment; mortality was only significantly enhanced in the unfed animals, which showed 100% mortality after 9 days. Egg production rates and hatching success from females in the unfed and toxic A. catenella treatments were all significantly lower than values observed in females fed Rhodomonas sp. or non-toxic A. catenella. Animals offered 1,000 μg C L–1 of Rhodomonas sp. and a 50:50 mixture of toxic A. catenella and Rhodomonas sp. produced significantly more eggs than animals fed toxic A. catenella alone. These results were not apparent at prey concentrations of 100 μg C L–1. The percentages of eggs to successfully hatch from females offered mono-specific diets of toxic A. catenella were always close to zero. Collectively, our results indicate that adult female A. tonsa can acquire sufficient energy from toxic A. catenella to survive, but suffer reproductive impairment when feeding on this prey alone.
Ammonia Stress Coping Strategy in a Highly Invasive Ascidian
Authors: Chen Yuqing , Huang Xuena , Chen Yiyong , Zhan Aibin
Published: April 2021

The outbreak of invasive ascidianMolgula manhattensishas negatively affected marine and coastal ecosystems and caused huge economic loss in various industries such as aquaculture. In mariculture systems usually characterized by high ammonia nitrogen, the capacity ofM. manhattensisto defend against drastic ammonia elevation plays a crucial role in its survival and subsequent invasions. However, ammonia coping strategies and associated genes/proteins remain largely unknown. Here we investigated rhesus glycoproteins (Rh)-mediated ammonia transport by identifying all Rh proteins and exploring their mRNA expression regulations under ammonia stress. Three types of primitive Rh proteins were identified, and all contained conserved amino acid residues and functional domains. Ammonia stress largely suppressed the expression of immune-related genes, but rapidly induced the increased expression of Rh genes. Ammonia was converted into glutamine as indicated by the increased expression of glutamine synthetase gene, rather than urea as illustrated by the stable expression of arginase gene. Collectively,M. manhattensismitigates ammonia challenge by enhancing ammonia excretion through Rh channels and detoxifying ammonia into glutamine. Our results provide insights into the molecular mechanisms underlying high tolerance and invasion success to high ammonia environments by invasive ascidians.
Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic “LIF” Into the Brain: Preclinical Proof of Concept
Authors: Flor Raul de la , Robertson Janette , Shevchenko Rostislav V. , Alavijeh Mo , Bickerton Sean , Fahmy Tarek , Metcalfe Su M.
Published: April 2021

Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppressive only. LIF is a vital stem cell growth factor active throughout life—and essential for health of the central nervous system (CNS), being tolerogenic, myelinogenic, and neuroprotective. Nano-formulation of LIF (LIFNano) using FDA-approved PLGA captures LIF's compound therapeutic properties, increasing potency 1,000-fold when targeted to CD4 (LIFNano-CD4). Moreover, circulating CD4+ lymphocytes are themselves regulated by LIF to express the Treg phenotype, known to release T cell-derived LIF upon engagement with cognate antigen, perpetuating antigen-specific self-tolerance. With the longer-term aim of treating inflammatory lesions of MS, we asked, does LIFNano-CD4 cross the blood–brain barrier (BBB)? We measure pK and pD using novel methodologies, demonstrate crossing of the BBB, show LIF-cargo-specific anti-inflammatory efficacy in the frontal cortex of the brain, and show safety of intravenous delivery of LIFNano-CD4 at doses known to provide efficacious concentrations of LIF cargo behind the BBB.
Autoimmune Encephalitis in Late-Onset Seizures: When to Suspect and How to Treat
Authors: Süße Marie , Zank Maria , von Podewils Viola , von Podewils Felix
Published: April 2021

Objective: This study was conducted to elucidate prevalence, clinical features, outcomes, and best treatment in patients with late-onset seizures due to autoimmune encephalitis (AE).

Methods: This is a single-institution prospective cohort study (2012–2019) conducted at the Epilepsy Center at the University of Greifswald, Germany. A total of 225 patients aged ≥50 years with epileptic seizures were enrolled and underwent an MRI/CT scan, profiling of neural antibodies (AB) in serum and cerebrospinal fluid (CSF), and neuropsychological testing. On the basis of their work-up, patients were categorized into the following three cohorts: definite, suspected, or no AE. Patients with definite and suspected AE were subsequently treated with immunosuppressive therapy (IT) and/or anti-seizure drug (ASD) therapy and were followed up (FU) regarding clinical and seizure outcome.

Results: Of the 225 patients, 17 (8%) fulfilled the criteria for definite or suspected AE according to their AB profile and MRI results. Compared with patients with no evidence of AE, those with AE were younger (p = 0.028), had mesial temporal neuropsychological deficits (p = 0.001), frequently had an active or known malignancy (p = 0.006) and/or a pleocytosis (p = 0.0002), and/or had oligoclonal bands in CSF (p = 0.001). All patients with follow-up became seizure-free with at least one ASD. The Modified Rankin scale (mRS) at hospital admission was low for patients with AE (71% with mRS ≤2) and further decreased to 60% with mRS ≤2 at last FU.

Significance: AE is an important etiology in late-onset seizures, and seizures may be the first symptom of AE. Outcome in non-paraneoplastic AE was favorable with ASD and IT. AB testing in CSF and sera, cerebral MRI, CSF analysis, and neuropsychological testing for mesial temporal deficits should be part of the diagnostic protocol for AE following late-onset seizures.
β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension
Authors: Tan Xing , Jiao Pei-Lei , Sun Jia-Cen , Wang Wen , Ye Peng , Wang Yang-Kai , Leng Yue-Qi , Wang Wei-Zhong
Published: April 2021

Oxidative stress in the rostral ventrolateral medulla (RVLM), a key region for blood pressure (BP) regulation, has been demonstrated to be responsible for the overactivity of the sympathetic nervous system in hypertension and heart failure. Nuclear factor-erythroid-2-related factor 2 (Nrf2) is a key transcription factor that maintains redox homeostasis by governing a broad array of antioxidant genes in response to oxidative stress. β-Arrestin1 is a multifunctional scaffold protein with the ability to interact with diverse signaling molecules independent of G protein-coupled receptors (GPCRs), and its overexpression in the RVLM could reduce BP and renal sympathetic nerve activity (RSNA) in spontaneously hypertensive rats (SHR). The goal of this study was to investigate whether Nrf2-mediated antioxidative stress is involved in the antihypertensive effect of β-arrestin1 in the RVLM. It was found that the activation level of Nrf2 in the RVLM of SHR was significantly reduced, compared with normotensive Wistar-Kyoko (WKY) rats. Overexpression of β-arrestin1 in the RVLM significantly decreased ROS production and facilitated the Nrf2 activation in the RVLM of SHR, accompanied by upregulating the expression of HO-1 and NQO-1. However, Nrf2 knockdown attenuated the antioxidant effect of β-arrestin1 overexpression in the RVLM by downregulating HO-1 and NQO-1 expression levels. In conclusion, the current results suggested that the antihypertensive effect of β-arrestin1 overexpression in the RVLM is mediated by decreased ROS production, which is associated with Nrf2 activation.
Lung Adenocarcinoma Patient Harboring EGFR-KDD Achieve Durable Response to Afatinib: A Case Report and Literature Review
Authors: Zhao Lingling , Wang Zhen , Du Haiwei , Chen Songan , Wang Pingli
Published: April 2021

The rapid development of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of patients with advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR mutations including but not limited to exon 19 deletions (19 del) and point mutation L858R in exon 21. However, the efficacy of EGFR-TKIs in patients with rare mutations, such as EGFR-kinase domain duplication (KDD), remains elusive. EGFR-KDD often results from in-frame tandem duplication of EGFR exons 18–25, causing subsequent constitutive activation of EGFR signaling. Several case reports have revealed the efficacies of EGFR-TKIs in advanced lung adenocarcinoma (LUAD) with EGFR-KDD but yielded variable antitumor responses. In the present study, we report a 61-year-old male patient diagnosed with T1N3M0 (stage IIIB) LUAD harboring EGFR-KDD involving exons 18–25. He was treated with afatinib and achieved partial response (PR) with progression-free survival (PFS) of 12 months and counting. Our work, confirming EGFR-KDD as an oncogenic driver and therapeutic target, provides clinical evidence to administer EGFR-TKIs in patients with advanced LUAD harboring EGFR-KDD.
Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support
Authors: Pérez Marín Maria , Prod'hom Sylvain , de Villiers Suzanne Francesca , Ferry Thomas , Amiet Vivianne , Natterer Julia , Perez Maria-Helena , Buclin Thierry , Chtioui Haithem , Longchamp David
Published: April 2021

Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism and involves an enterohepatic circulation, with a small contribution of renal elimination (10–30%). Colchicine toxicokinetics is however rarely described, especially in children. We present the case of a 4-year-old patient who survived a severe iatrogenic colchicine intoxication with a dose of 0.5 mg/kg. She developed multi-organ failure and shock, but recovered after receiving aggressive resuscitation, including extracorporeal life support. Close monitoring of colchicine blood levels showed a plateau for 6 days, indicating impeded elimination resulting from liver failure. We observed no significant clearance from renal replacement therapy, nor activated charcoal, during this period. Extracorporeal life support may play a supportive role in the management of severe colchicine poisoning. However, extracorporeal techniques do not seem to improve colchicine elimination.
Comparison of Two Techniques of Superior Vena Cava Flow Measurement in Preterm Infants With Birth Weight <1,250 g in the Transitional Period—Prospective Observational Cohort Study
Authors: Miletin Jan , Stranak Zbynek , Ó Catháin Niamh , Janota Jan , Semberova Jana
Published: April 2021

Objectives: Superior Vena Cava (SVC) flow in neonates measured by the standard approach has been validated by different groups around the world. The modified SVC flow measurement technique was recently suggested. The aim of our study was to evaluate standard and modified technique of echocardiography SVC flow measurement in a cohort of extremely preterm neonates in the immediate postnatal period.

Methods: Prospective, observational cohort study in a level III neonatal center. Infants with birth weight <1,250 g were eligible for enrolment. SVC flow was measured by echocardiography using standard and modified methods at 6, 18 and 36 h of age. Our primary outcome was equivalency (using raw bounds of −20 to +20 mL/kg/min difference between the paired measurements), agreement and correlation between standard and modified methods of the SVC flow measurements.

Results: Thirty-nine infants were enrolled. The mean gestational age of the cohort was 27.4 (SD 2.1) weeks of postmenstrual age, the mean birth weight was 0.95 kg (SD 0.2). The measurements at 6 and 36 h of age were equivalent as defined in the design of the study (p = 0.003 and p = 0.004 respectively; raw bounds −20 to +20 mL/kg/min). At 6 h of age the mean difference (bias) between the measurements was −0.8 mL/kg/min with 95% limits of agreement −65.0 to 63.4 mL/kg/min. At 18 h of age, the mean difference (bias) between the measurements was +9.5 mL/kg/min, with 95% limits of agreement −79.6 to 98.7 mL/kg/min. At 36 h of age the mean difference (bias) between the measurements was −2.2 mL/kg/min with 95% limits of agreement −73.4 to 69.1 mL/kg/min. There was a weak, but statistically significant correlation between the standard and modified method at 6 h of age (r = 0.39, p = 0.04).

Conclusion: Both SVC flow echocardiography measurement techniques yielded clinically equivalent results, however due to wide limits of agreement and poor correlation they do not seem to be interchangeable.
Compensation Preferences: The Role of Personality and Values
Authors: Julian Amanda M. , Wijngaard Onno , de Vries Reinout E.
Published: April 2021

The present study investigated relations between personality and values on the one hand and compensation preferences on the other. We hypothesized that HEXACO Honesty-Humility and self-transcendence versus self-enhancement values predict preference for higher relative compensation level and that HEXACO Openness to Experience and openness to change versus conservation values predict preference for compensation variability. Furthermore, we expected perceived utility of money and risk aversion to mediate the respective relations. The hypotheses were tested using a sample of 2,210 employees from a large international organization. The results provided support for the direct and mediated relations between personality and values on the one hand and preferences for compensation variability and level on the other.
Improving on Half-Lightweight Male Judokas' High Performance by the Application of the Analytic Network Process
Authors: Uriarte Marcos Sugoi , Rodríguez-Rodríguez Raúl , Alfaro-Saiz Juan-José , Carballeira Eduardo , Uriarte Marcos Maier
Published: April 2021

Judo is a multifactorial sport where many variables or key performance indicators (KPIs) such as force-velocity profile, bioenergetic capacity, technical and tactical skills, and cognitive and emotional competence play a role and influence the final result. While there have been many academic studies of these variables, usually in isolation, none have examined KPIs holistically or analyzed their impact on strategic performance. The main objective of the present study, therefore, is to apply a novel and easily replicable methodology to identify and prioritize the main KPIs affecting performance in professional judo. Such a methodology was applied to the High-Performance Judo Centre of Valencia, using a multi-criteria decision aid technique: the analytic network process (ANP). The ANP is used to identify and quantify cause and effect relationships not only between KPIs but also between KPIs and performance objectives. Further, the ANP offers effective results when there is a lack of historical KPI data, because it is based on experts' opinions and judgments. A judo expert group (JEG) comprising elite judo coaches and half-lightweight (under 66 kg) male judokas applied the methodology to discriminate between the characteristics required when aiming to reach high-level strategic objectives (such as participating in the Olympic Games or winning a medal in a Grand Slam/Gran Prix). The JEG, which consisted of five elite judokas, national and international champions, and three Olympic coaches—including a former European champion and silver medalist in a world championship—provided high added value to the study. The main findings were that the KPIs that made the most difference were mostly psychological, specifically motivation, stress, and team cohesion. Of these, motivation was by far the most important KPI for success in our case study, so judokas should make sure that they analyze it properly. Motivation is usually intrinsic to the competitor and should be maintained at a high level, not only during tournaments but also during daily training and lifestyle activities. Physical and other specific forms of training, as well as lifestyle KPIs, are very important for the elite competitor but are not sufficient to reach high-level objectives. The most important of these KPIs were Kumi-Kata (grip work), dual career, focus and concentration level, scouting, nutrition, and basic technique. Power and strength were the most important physical KPIs. In general, these are essential for meeting strategic objectives, but they do not make the crucial difference. This suggests that professional psychological support should be provided in daily training and that international team composition and internships should be fostered.
How Does Happiness Influence the Loyalty of Karate Athletes? A Model of Structural Equations From the Constructs: Consumer Satisfaction, Engagement, and Meaningful
Authors: Núñez-Barriopedro Estela , Cuesta-Valiño Pedro , Gutiérrez-Rodríguez Pablo , Ravina-Ripoll Rafael
Published: April 2021

Federations are concerned about attracting new sportsmen and sportswomen and increasing the number of members. The purpose of this research was to describe karate federations' strategies for attracting and retaining members through happiness. The analysis was carried out by designing a structural equation modeling (SEM), which allowed to analyze the main variables that influenced the happiness of the karate athlete and consequently to study their effect on people's loyalty to sports federations. In particular, Partial least squares SEM was applied in an overall model when it was possible to understand the happiness role in relation with other traditional relevant variables on loyalty. The data were obtained through primary sources employing a survey sent to the autonomous federations in the discipline of karate, obtaining a sample of 682 federated members in Spain. The results of the model revealed that consumer satisfaction, engagement, and meaningful influence on consumer happiness, but engagement was the most important and relevant variable for affecting this variable. Finally, consumer satisfaction and consumer happiness influence loyalty, and consumer satisfaction was the most important variable, but consumer happiness showed a real alternative for improving loyalty in karate sports federations. Then, one of the implications of this work was that it helped to explain how the federations can be managed to achieve loyal consumers together with a more considerable increase in the number of federated members.
A Study on the Relationship Between Physical Activity, Sedentary Behavior, and Sleep Duration in Preschool Children
Authors: Chang Zhenya , Lei Wei
Published: April 2021

Purpose: Explore the role of physical activity (PA) and sedentary behavior (SB) in the sleep of preschool children.

Method: Preschool children (n = 458) from kindergarten were recruited, measures included accelerometer-derived 24 h activity [SB, light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), daytime sleep duration (DSP), and nocturnal sleep duration (NSP)]. A self-made questionnaire was used to supplementary survey on different types of SB. The two-layer chi-square test and the Cochran–Mantel–Haenszel test were used and significance set at p < 0.05.

Results: PA is mainly a protective factor for DSP, while SB is mainly a risk factor for NSP of preschool children; Screen-type SB including screen viewing SB and video game SB is a risk factor for NSP, while quiet learning SB have no significant correlation with sleep duration in preschool children; Gender and social economic status are important factors affecting the association of PA, SB, and sleep duration in preschool children.

Conclusions: The relationship between sleep duration at different periods and PA and SB of preschool children is different. Future educators need to gradually realize the different factors affecting the sleep of preschool children at different stages, clarify the protective factors and risk factors, in order to improve the sleep duration of preschool children.
Why Is Rehabilitation Assistance Policy for Children With Disabilities Deviated in Supply-Demand? A Case Study in Mainland China
Authors: Qi Cai Yun , Wang Yuan
Published: April 2021

Children with disabilities have most potential for salvage rehabilitation, and their rehabilitation results are concerned with their entire life process. Although, the Chinese state has established a targeted Rehabilitation Assistance System for Disabled Children and has expanded the provision of rehabilitation services, a severe deviation between supply and demand remains. Existing studies have focused relatively more on policy content and less on the policy context, at the macro-structural level. However, using the case of the ZW Rehabilitation Center in City J, this study divided the deviation into exclusion errors and inclusion errors, and used the policy context approach to explore the reasons for the deviation. We found that the behaviors of the participants in rehabilitation services exist in a dynamic interaction between the regulatory context, the normative context, and the cognitive context. The joint forces of the three contexts produce both exclusion errors and inclusion errors, which are the underlying reasons for the inaccurate execution of the targeted policy. The results of this research can provide enlightenment for improving rehabilitation policy.
Rangeland Ecosystem Service Markets: Panacea or Wicked Problem?
Authors: Roche Leslie M. , Saitone Tina L. , Tate Kenneth W.
Published: April 2021

Rangelands support nearly one-third of Earth's population and provide a multitude of ecosystem services. Land managers and society face increasing pressures to sustainably intensify rangeland food systems; therefore, the time is ripe for thoughtful approaches to simultaneously produce more food, provide economic opportunities for livestock-dependent communities, and enhance environmental benefits from rangeland ecosystems. Payments for ecosystem services (PES) programs have been put forth as potential mechanisms to maintain the quality and quantity of ecosystem services while enhancing economic viability of livestock operations. Free markets have long been proposed as solutions for mitigating trade-offs from ecosystem services that are not co-produced with livestock production; such markets have failed to emerge at the scale required to address global threats to sustainability. We highlight fundamental obstacles on demand and supply sides that challenge the concept of a market as a panacea; we do so through an interdisciplinary lens of fundamental economic underpinnings overlaid with a social survey of cattle producers' perspectives. Relevant to the demand side, we discuss the most significant impediments to development and function of non-bundled ecosystem service markets; on the supply side, we provide unique perspectives, using novel interview data from California rangeland cattle producers. Producer interviews highlighted substantial financial challenges threatening the economic sustainability of their operations. Among interviewed producers, 85% identified government regulations as the central threat to their livelihoods. Producers identified opportunities for enhancing enterprise sustainability via improved value and marketing of livestock goods co-produced with ecosystem services, participation in conservation easements, and improved connections with society. Only 11% of producers identified PES programs as future opportunities. When asked about willingness to participate in PES markets, 13% of interviewees indicated they would not, 45% were neutral, and 42% indicated they would consider participating. Interviewees stated trust in the market broker is key and they would be less willing to participate if there was government involvement. Ecosystem service markets—whether voluntary or non-voluntary—are likely not sustainable solutions to the complex social-economic-ecological dilemma ranchers and society face. Sustainability on working rangelands will require partnerships to co-develop strategies to build more equitable food systems and sustain these ecosystems.
Psychological and Forensic Challenges Regarding Youth Consumption of Pornography: A Narrative Review
Authors: Gassó Aina M. , Bruch-Granados Anna
Published: April 2021

Nowadays, technology has become part of the daily activities of a large part of the population. Many of the activities and development and socialization processes of minors and young people have been transferred to the online world, generating attention and concern from the educational, scientific, and forensic communities. One of the most worrying issues derived from this new online world is the consumption of pornography by teens. The objective of this literature review is to draw attention to the consequences and emotional disturbances derived from the consumption of pornography in young people, as well as the forensic implications of this phenomenon, among which are paraphilias, perpetration, and victimization of sexual assaults, and the development of new forms of online sexual victimization. The main findings suggest that the first contact with pornography starts at the age of 8 years old, with important behavioral and psychological consequences, such as hypersexualization, emotional disturbances, and the perpetuation of gender inequality. Furthermore, pornography consumption by youth has been linked to the exacerbation of paraphilias, an increase in sexual aggression perpetration and victimization, and, finally, it has been linked to an increase in online sexual victimization. Implications and future lines of research are discussed.
Impact of Partial Root Drying and Soil Mulching on Squash Yield and Water Use Efficiency in Arid
Authors: Farah Abdulhalim H. , Al-Ghobari Hussein M. , Zin El-Abedin Tarek K. , Alrasasimah Mohammed S. , El-Shafei Ahmed A.
Published: April 2021

Practical and sustainable water management systems are needed in arid regions due to water shortages and climate change. Therefore, an experiment was initiated in winter (WS) and spring (SS), to investigate integrating deficit irrigation, associated with partial root drying (PRD) and soil mulching, under subsurface drip irrigation on squash yield, fruit quality, and irrigation water use efficiency (IWUE). Two mulching treatments, transparent plastic mulch (WM) and black plastic mulch (BM), were tested, and a treatment without mulch (NM) was used as a control. Three levels of irrigation were examined in a split-plot design with three replications: 100% of crop evapotranspiration (ETc), representing full irrigation (FI), 70% of ETc (PRD70), and 50% of ETc (PRD50). There was a higher squash yield and lower IWUE in SS than WS. The highest squash yields were recorded for PDR70 (82.53 Mg ha−1) and FI (80.62 Mg ha−1). The highest IWUE was obtained under PRD50. Plastic mulch significantly increased the squash yield (34%) and IWUE (46%) and enhanced stomatal conductance, photosynthesis, transpiration, leaf chlorophyll fluorescence, and leaf chlorophyll contents under PRD plants. These results indicate that in arid and semi-arid regions, soil mulch with deficit PRD could be used as a water-saving strategy without reducing yields.
Effect of Preconception Selenium Intake on the Risk for Gestational Diabetes: The Japan Environment and Children’s Study
Authors: Kyozuka Hyo , Murata Tsuyoshi , Fukuda Toma , Yamaguchi Akiko , Kanno Aya , Yasuda Shun , Sato Akiko , Ogata Yuka , Hosoya Mitsuaki , Yasumura Seiji , Hashimoto Koichi , Nishigori Hidekazu , Fujimori Keiya
Published: April 2021

Selenium (Se) acts as a cofactor of antioxidant enzymes. Preconception care may reduce the risk of gestational diabetes mellitus (GDM). We examined the association between preconception Se intake and the risk of GDM in Japanese women. Using the Japan Environment and Children’s Study database, we identified 92,764 Japanese women recruited between January 2011 and March 2014. Participants were categorized into five groups according to preconception Se intake quintiles (Q1 and Q5 were the lowest and highest Se intake groups, respectively). GDM was categorized as early-onset (Eo-GDM) or late-onset (Lo-GDM) diagnosed before or after 24 weeks, respectively. Multiple logistic regressions were performed to identify the effect of preconception Se intake on GDM, Eo-GDM, and Lo-GDM. Using Q3 (the middle Se intake group) as the reference, a multiple logistic regression analysis showed that the highest (Q5) Se intake group demonstrated increased risks of GDM (adjusted odds ratio (aOR): 1.15, 95% confidence interval (CI): 1.01–1.30) and the lowest (Q1) Se intake group had increased risks of Lo-GDM (aOR: 1.19, 95% CI: 1.01–1.41). Thus, both high and low preconception Se intakes increase risks of glucose intolerance during pregnancy. This finding may indicate new recommendations for preconception Se intake to prevent GDM.
Bearing Fault Diagnosis Approach under Data Quality Issues
Authors: AlShalalfeh Ashraf , Shalalfeh Laith
Published: April 2021

In rotary machinery, bearings are susceptible to different types of mechanical faults, including ball, inner race, and outer race faults. In condition-based monitoring (CBM), several techniques have been proposed in fault diagnostics based on the vibration measurements. For this paper, we studied the fractal characteristics of non-stationary vibration signals collected from bearings under different health conditions. Using the detrended fluctuation analysis (DFA), we proposed a novel method to diagnose the bearing faults based on the scaling exponent (α1) of vibration signal at the short-time scale. In vibration data with high sampling rate, our results showed that the proposed measure, scaling exponent, provides an accurate identification of the health state of the bearing. At the end, we evaluated the performance of the proposed method under different data quality issues, data loss and induced noise.
Performance Evaluation of Buried Concrete Pipe Considering Soil Pressure and Crack Propagation Using 3D Finite Element Analysis
Authors: Ban Hoki , Roh Seungjun , Park Won-Jun
Published: April 2021

Numerous factors affect the soil pressure distributions around buried pipes, including the shape, size, and stiffness of the pipe, burial depth, and the stiffness of the surrounding soil. Additionally, to some extent, a pipe can benefit from the soil arching effect, where the overburden and surcharge pressure at the crown can be supported by the adjacent soil. As a result, a buried pipe only needs to support the portion of the load that is not transferred to the adjacent soil. This paper presents numerical investigations of the soil pressure distributions around buried concrete pipes and crack propagation under different environmental conditions, such as loading, saturation level, and the presence of voids. To this end, a nonlinear elastoplastic model for backfill materials was implemented using finite element software and a user-defined subroutine. Three different backfill materials and two different native soils were selected to examine the material-specific behaviors of concrete pipes, including soil pressure distributions and crack propagation. For each backfill material, the effects of the loading type, groundwater, and voids were investigated. These simulation results provide helpful information regarding pressure redistribution and buried concrete pipe behavior under various environmental conditions.
LCA Practices of Plastics and Their Recycling: A Critical Review
Authors: Kousemaker Timothy M. , Jonker Gerald H. , Vakis Antonis I.
Published: April 2021

In a bid to help address the environmental footprints associated with products and services, life cycle assessment (LCA) applications have become increasingly popular throughout the years. This review summarizes some important methodological developments in recent years, such as the advent of dynamic LCA, as well as highlighting recent LCA applications in the context of plastics/recycling with a focus on their methodological choices. Furthermore, this review aims to offer a set of possible research lines to improve the gap between LCA and decision-making (policy). It was found that the majority of reviewed papers are mostly conservative in their methodological practice, employing mostly static analyses and making little use of other methods. In order to bridge the gap between LCA and policy, it is suggested to broaden system boundaries through the integration of dynamic modelling methods, incorporating interactions between fore- and background systems, and including behavioral components where relevant. In addition, advanced sampling routines to further explore and assess the policy space are recommended. This is of paramount importance when dealing with recycling processes as the molecules/polymers constituting the output of those processes have to be benchmarked in terms of costs and, crucially, their sustainability character against virgin ones.