bluuebunny/crossref_metadata_2025 huggingface dataset:
Late Quaternary evolution of alluvial fans in the Playa, El Fresnal region, northern Chihuahua desert, Mexico: Palaeoclimatic implications
Authors: Ortega-Ramírez J. , Maillol J. M. , Bandy W. , Valiente-Banuet A. , Urrutia Fucugauchi J. , Mortera-Gutiérrez C. A. , Medina-Sánchez J. , Chacón-Cruz J.
Published: April 2023

Estudios multidisciplinarios de geología del Cuaternario, ecología y geofísica en la región que actualmente ocupa el Lago-playa El Fresnal, norte del estado de Chihuahua, indican que se trata de una cuenca en extensión de tipo medio-graben, caracterizada por un lago-playa en la parte basal, rodeado por piemontes cubiertos por abanicos aluviales. El tectonismo extensional produjo zonas de fallas normales, bloques basculados con expresiones geomórficas diferenciales y volcanismo. El area del bloque levantado es la fuente principal de aportes detríticos; sin embargo, debido ala naturaleza asimetrica de la cuenca, los sedimentos provenientes del bloque hundido se encuentran espacialmente mas distribuidos. Resultado del bascularniento, los abanicos aluviales se segmentaron quedando las superficies mas antiguas en Ia parte distal del bloque levantado y en Ia parte proximal del bloque hundido.

Hasta ahora, la evolución de los abanicos aluviales ha sido considerada como el resultado de las variables tectónicas y climáticas; sin embargo, la función e importancia relativa que estas tienen en el control de la sedimentación tanto de los abanicos aluviales como de los rellenos de la cuenca no ha sido aun resuelto. Por ejemplo, algunos autores enfatizan la influencia de los cambios climáticos, mientras que otros ponderan el efecto de la actividad tectónica. En el presente trabajo se analizan los aspectos geomorfológicos de los abanicos aluviales, su posición topográifica relativa, el grado de disección y desarrollo de suelos, el tipo de drenaje, y de manera general, las distintas facies sedimentarias. Nuestros resultados indican que en la región existen tres generaciones de abanicos aluviales, formados durante las principales variaciones climaticas del Cuaternario Tardío. Esta interpretación es consistente con los principales cambios climáticos registrados en la estratigraffa paleolacustre del norte de México y del suroeste de los Estados Unidos. Los abanicos aluviales estan formados principalmente por depósitos de tipo debrisflow, resultado de precipitaciones abundantes de corta duración, producidas probablemente por cambios en las condiciones climaticas de relativamente húmedas a aridas. Las facies sedimentarias de estos depósitos contrastan con las producidas por regímenes tipicamente fluviales.doi: sin doi
Aquifer vulnerability mapping and GIS: A proposal to monitor uncertainty associated with spatial data processing
Authors: Murat Valerie , Rivera Alfonso , Pouliot Jacynthe , Miranda-Salas Marcelo , Savard Martine M.
Published: April 2023

El Servicio Geológico de Canadá llevo a cabo una evaluación acuífera para estimar la sustentabilidad y Ia vulnerabilidad acuífera en St. Lawrence Lowlands al suroeste de Quebec. El modelo DRASTIC y un SIG fueron usados para calcular y producir los mapas de vulnerabilidad. Paralelamente se realizó un detallado monitoreo del procesamiento de los datos para controlar la exactitud de los mapas de vulnerabilidad. Una estimación global incluyo errores identificados e incertidumbres asociadas con datos espaciales y descriptivos usados en el modelo. Los datos analizados se relacionaron con los pozos, perforaciones, mapas temáticos, y también con los procesos múltiples de los datos incluyendo a los errores e incertidumbre atribuidas a los cálculos de la conductibilidad hidráulica, las interpolaciones de los datos, las intersecciones de capas de los datos espaciales etc. Se propone un sistema de categorización usando el lenguaje UML, para categorizar datos espaciales con respecto al grado y fuente de incertidumbre. Este trabajo presenta este sistema, un ejemplo de aplicación en un área estudiada y una discusión sobre su utilidad en el control del procesamiento de datos. También muestra que Ia incertidumbre asociada con el procesamiento de datos espaciales y la integración de los datos a un sistema numérico puede ser muy significante; Ia principal ambigüedad ocurre cuando se limpian datos, se interpolan, se clasifican y se sobreponen. La caracterización de la incertidumbre en los procesos de los datos fue una valiosa fuente de información tan crucial como la misma calidad de los datos. Monitorear la incertidumbre asociada con el procesamiento de datos espaciales es casi tan importante como el modelo mismo. Sin embargo, el monitoreo de la incertidumbre puede ser complejo y subjetivo y de hecho es raramente efectuado sobre bases regulares principalmente porque requiere mucho más esfuerzo comparado con simplemente correr el modelo.doi: sin doi
Assessing rock aquifer vulnerability using downward advective times from a 3D model of surficial geology: A case study from the St. Lawrence Lowlands, Canada
Authors: Ross Martin , Martel Richard , Lefebvre Rene , Parent Michel , Savard Martine M.
Published: April 2023

Se verifica en St. Lawrence Lowlands en SW Quebec un método de evaluación de vulnerabilidad acuífera, el cual relaciona directamente Ia vulnerabilidad con el tiempo advectivo descendiente (DAT) a partir de un modelo geológico 3D. El objetivo fue evaluar Ia vulnerabilidad del acuífero regional, el cual es sobreyacido por unidades Cuaternarias discontinuas y no consolidadas. Parámetros hidrogeológicos como Ia recarga y la porosidad de cada unidad sobreyaciente fueron integrados a una malla estratigráfica gOcad. Esta malla fue generada a partir de un modelo geológico hecho con superficies entrelazadas representando las fronteras de las unidades Cuaternarias y Ia topografía del basamento. Se hicieron cálculos usando 1m enfoque determinístico y valores de DAT fueron obtenidos para el 74% del área en estudio. Los resultados son agrupados en 6 clases DAT, los cuales son interpretados en términos de un índice de vulnerabilidad relativa. La distribución espacial de este índice concuerda con el escenario hidrogeológico y los datos hidrogeoquímicos disponibles. Los resultados indican que 40% del área evaluada cae en clases de moderadamente alta a muy alta vulnerabilidad. Una comparación entre este mapa y no DRASTIC de Ia misma área revelan algunas discrepancias significantes, particularmente en áreas de profundidad somera a! basamento, las cuales son caracterizadas por rápidos DAT a través de Ia delgada zona vadosa. En estas áreas DRASTIC produce vulnerabilidades bajas mientras esta evaluación da valores altos de vulnerabilidad. Esta valoración provee bases legítimas para una planificación regional y !a toma de decisiones.doi: sin doi
Vulnerability assessment of aquifers in an urban-rural environment and territorial ordering in Leon, Mexico
Authors: Tovar Martin , Rodríguez Ramiro
Published: April 2023

Evaluaciones regionales de vulnerabilidad acuífera, DRASTIC y AVI, son adecuadas a una escala local para analizar el uso de suelo en la zona sudoeste de la ciudad de León, Guanajuato, Mexico. Los mapas temáticos a base de isolíneas son transformados en mapas de rejilla para ser utilizados en un Sistema de información Geográfica, GIS. Las principales fuentes potenciales de contaminación acuífera son incluidas en el análisis del ordenamiento territorial. Se analizan conjuntamente tendencias de vulnerabilidad y usos de suelo. Se revisan las tendencias de expansión urbana de acuerdo con la vulnerabilidad que presenta el acuífero. Se definen áreas restrictivas para el desarrollo urbano por su alta vulnerabilidad.doi: sin doi
Estimation of the vulnerability to saline intrusion of the coast of Hermosillo aquifer, Sonora, Mexico
Authors: Rangel-Medina Miguel , Monreal S. Rogelio , Morales M. Mariano , Castillo Gurrola José
Published: April 2023

La contaminación del agua subterránea tiene una amplia variedad de propagación ya sea fuentes puntuales o dispersas y su vulnerabilidad o el riesgo se han evaluado con métodos como DRASTIC, A VI, GOD, EPIK, SINTACS y otros, que poseen un común denominador, los contaminantes son adicionados sobre o cerca de la superficie del terreno. A diferencia de este mecanismo, la intrusión salina, o contaminación del agua dulce por agua de mar en acuíferos costeros, involucra características hidrogeológicas distintas de degradación. Ello obliga a usar metodologías más extensas, tardadas y a veces con alto grado de complejidad, pues el conocimiento de escenarios hidrogeológicos necesita de numerosas herramientas para la obtención de parámetros. En la costa noroeste del Pacifico mexicano, los principales acuíferos están gravemente afectados por sobrebombeo agrícola. El acuífero de la Costa de Hermosillo en Sonora ha sido intrusionado hasta 32 km tierra adentro; ello degrado la calidad del agua alcanzando conductividades eléctricas de hasta 40 000 J.lS/cm. Para conocer las zonas vulnerables por donde penetra diferencial y preferencialmente el agua de mar desde hace 37 años se actualizo el modelo hidrogeológico e identificaron la migración y posición del frente de intrusión utilizando la geometría del basamento, la hidroestratigrafía y propiedades del acuífero, obteniéndose a partir de ellas una clasificación de vulnerabilidad para tres zonas de riesgo: 1) Zona de vulnerabilidad Alta por subsidencia tectónica, 2) Zona de vulnerabilidad Media por permeabilidad del medio, 3) vulnerabilidad Baja definida por altos gravimétricos.doi: sin doi
Models for wellhead protection in regional unconfined aquifers and stratified aquifers
Authors: Lobo Ferreira J. P. , Krijgsman B. , Feseker T.
Published: April 2023

En este trabajo son presentados los conceptos matemáticos usados para el desarrollo de la protección de cabezales de pozos y la metodología de zonificación. Ellos están basados en soluciones analíticas, en el flujo del agua subterránea y en la modelación en diferencias finitas del rastreo de partículas. Los límites de la protección de cabezales de pozos están en función no solo de la geología local, de los parámetros del acuífero y de las características regionales del acuífero, también de los caudales de extracción (o de la productividad del acuífero). Verticalmente el análisis fue realizado usando un modelo de flujo simétrico a un eje asumiendo que el flujo de agua subterránea hacia el pozo es radial. Las herramientas matemáticas fueron desarrolladas para ser robustas y de uso amigable, facilitando la aplicación de la nueva legislación portuguesa relacionada con la protección del agua subterránea. La aplicación de la metodología es ejemplificada en dos estudios de caso, uno desarrollado para el acuífero costero de Bardez, en el estado de Goa, India y el otro en Ramahal, Portugal.doi: sin doi
Intensive exploitation effects on alluvial aquifer of the Catania plain, eastern Sicily, Italy
Authors: Ferrara V. , Pappalardo G.
Published: April 2023

El crecimiento de un área industrial en la parte este de la Llanura de Catania en Sicilia ha causado una intensa explotación del agua subterránea, con consecuencias negativas en su equilibrio hidrodinámico y en la degradación de la calidad del agua. En este trabajo, la porción este de la llanura localizada entre el Monte Etna y la meseta Hyblean, es analizada por medio de las características litológicas de perforaciones y datos de resistividad, los cuales han permitido la reconstrucción de las relaciones geométricas en el depósito y sus variaciones de espesor. La variabilidad granulométrica de los depósitos aluviales (arena, cieno y grava) y su permeabilidad relativa son características de un típico acuífero multicapa que es libre en la parte superior y parcialmente confinado en su porción inferior. Descansa sobre un susbstrato de arcillas marinas cuya morfología es afectada por estructuras tectónicas controlando el espesor del acuífero. La piezometría muestra una pronunciada depresión causada por el descenso del nivel estático cercano a los 2m anuales desde 1962 debido al bombeo de los pozos industriales. Esto también ha inducido infiltración de agua de mala calidad desde el acuífero contaminado sobreyaciente, mientras que perforaciones exploratorias profundas han causado una extensa contaminación del acuífero debido a los cloruros contenidos en el agua de las lentes arenosas dentro de las arcillas marinas subyacentes.doi: sin doi
Vulnerability maps pollution to hydrocarbon and urban waste pollution in seawater intrusion areas
Authors: Aureli A. , Carrubba S. , Cusimano G. , Dipasquale M. , Mazzurco N. , Privitera A.M.G. , Silluzio C. , Tosto S. , Zingale V.
Published: April 2023

De acuerdo con un proyecto nacional promovido por el Grupo Nacional Italiano para la Protección contra Riesgos Hidrogeológicos han sido publicados los mapas de vulnerabilidad (1:50.000) de parte del Territorio Italiano, particularmente algunos mapas de Sicilia: Montes Iblei, Moadonie, Sicani y el Monte Etna. Estos mapas se han vuelto documentos públicos para el manejo local del agua subterránea. Algunos fenómenos muy peligrosos han sido reportados en algunas áreas de Sicilia. Intervenciones antrópicas han creado basureros de residuos tóxicos sobre áreas vulnerables. Esta investigación explica las ventajas del uso de mapas de vulnerabilidad en estudio de tipos peligrosos de contaminación para la situación encontrada en el área de Augusta-Priolo, Sicilia, en la cual un complejo petroquímico ha sido instalado. Aspectos hidrogeológicos y petroquímicos son examinados para evaluar las posibilidades de intervención preventiva y de reclamación. En las mismas áreas, en regiones costeras, la intrusión marina esta incrementándose progresivamente.doi: sin doi
Seismic parameter evaluation of gravel and sand samples subjected to stress using general purpose piezocrystals
Authors: Imhof Armando Luis , Santamarina Juan Carlos
Published: April 2023

Se presenta el desarrollo e implementación de técnicas geofísicas altamente resolutivas basadas en Ia transmisión de ondas elásticas en gravas y arenas secas mediante el empleo de instrumental de bajo costo desarrollado para este estudio. Las técnicas fueron aplicadas en muestras de arenas y gravas a escala de laboratorio con diferentes grados de compactación. La adquisición de datos se efectuó utilizando piezocristales de muy bajo costo como emisores y receptores de señales, y otros dispositivos sencillos tales como microprocesadores TL084 como amplificadores analógicos. Como sismógrafo y convertidor A-D de las señales se empleó un osciloscopio Tektronix TDS 210 con capacidad de almacenamiento de datos en PC. Las muestras fueron sometidas a varios estados de esfuerzo con el propósito de simular profundidades crecientes. Se observó una correlación marcada entre las velocidades de propagación VP y los espectros de frecuencia con los esfuerzos efectivos aplicados que reflejaron el carácter inherentemente no-lineal de los contactos entre partículas, tal como lo describe el modelo hertziano. Durante el ciclo de descarga, los valores de VP fueron mayores que los correspondientes al ciclo inicial de carga, debido a Ia reubicación (y compactación) de los granos durante el mismo. Por consiguiente, es posible conocer el estado de compactación de las partículas en una muestra dada estudiando la propagación de ondas sísmicas, las cuales se calculan antes y después de Ia carga.doi: sin doi
Seismic characterization of station LNIG as a reference site in Northeast Mexico
Authors: Ramos-Zúñiga Luis G. , Montalvo-Arrieta Juan C. , Pérez-Campos Xyoli , Valdés González Carlos
Published: April 2023

La estación LNIG forma parte de Ia nueva generación de observatorios sismológicos que han sido instalados en los últimos a nos en Ia Republica Mexicana por el Servicio Sismológico Nacional (Mexico). La estación LNIG se instaló en enero de 2006 en terrenos de Ia Facultad de Ciencias de Ia Tierra de Ia Universidad Autónoma de Nuevo León en Linares, Nuevo León, Mexico. Evaluamos Ia respuesta de sitio de Ia estación LNIG de acuerdo con Ia definición del sitio estándar de referencia. Se obtuvo (a) el valor promedio de velocidades de ondas de corte para los primeros 30 m del subsuelo, V530, y (b) Ia frecuencia de resonancia. A partir de perfiles de refracción sísmica, obtuvimos V530 = 1870 m/s. De acuerdo con Ia NEHRP, corresponde a un sitio clase A (roca dura o macizo rocoso). La frecuencia de resonancia fue obtenida mediante cocientes espectrales H/V de registros de microtremores y de sismos locales (3.1 ≤; M : ≤; 4.5), los cuales muestran una respuesta plana con amplitud unitaria, para el rango de frecuencias de 0.2 a 20 Hz. De acuerdo con Ia definición propuesta por Steidl et at. ( 1996) y Cadet et al. (2010), Ia estación sismológica LNIG queda definida como un sitio de referencia, el cual se encuentra asentado sobre lutita de Ia Formación Méndez del Cretácico superior.doi: sin doi
Design and Implementation of an IOT Enabled Classified Authentication System using LabVIEW
Authors: Gangopadhyay Dr. Amit
Published: April 2023

Abstract: This paper describes the development of an authentication system with Internet of Things (IOT) enabled solution and the dashboard support with mobile applications. This Authentication system is composed of NI myRIO embedded controller with the proximity detection sensor, which senses the presence of the person in front of the device setup. After sensing a person in front of the system, GSM module is utilized to send the unique One Time Password (OTP) to the owner of the system for accessing and will provide an option of entering the OTP through the assembled thumbwheel switches. Once after entering the password, on board button of NI myRIO has to be pressed to make an entry of the password into system. If password matches with master database OTP, authentication will be provided to the end user along with LED glowing status and motor rotation will be turned on. If the password doesn’t match with the master database password, the buzzer will be blowing indicating the authentication failure that means access denied. In both the cases the data will be updated to cloud through dweet IOT service and the same status can be even updated into dash board application.
IOT Based College Notice Board LED Display
Authors: Teja Koppolu Sai , Maharana Swasthidipa , Reddy Thummala Ashan
Published: April 2023

Abstract: This project aims to develop a smart notice board system using P10 LED display and IoT technology. The system is designed to display important messages in schools, colleges, banks, and other public places. The system is controlled by an Atmega32p microcontroller, which interfaces with the Wi-Fi module and P10 LED display. Text-based commands are transmitted through Wi-Fi and received by the esp8266 Wi-Fi module. The microcontroller processes the information and scrolls the message on the P10 LED display. The system replaces the older message with a new one. The Atmega32p is loaded with an intelligent program written in embedded ‘C’ language to perform the task. The system provides an efficient and effective way of displaying important information to the public. The project is a cost-effective solution that can be implemented in various settings to improve communication and information dissemination. The system can be remotely managed through an Android SSH client such as JuiceSSH. Overall, the project provides an effective solution for displaying important information to the public in various settings.
Review on Efficient Multi-Objective Optimization for the Vehicle Routing Problem with Time Window to Enhance Resilience
Authors: Raj Mayank , K V Dr. Praveen Kumar
Published: April 2023

Abstract: The Vehicle Routing Problem under time window uncertainty A new type of travel time disturbance is constructed to capture the characteristics of the life scenario, and its disturbance region is determined by the maximum disturbance degree Two objectives are defined to minimise the total distance and the number of vehicles An advanced Robust Multi Objective Particle Swarm Optimization approach is developed using advanced coding, decoding model, reliability metrics and local search strategies to identify optimal solutions Due to the particles in the decision space, the properties of the problem space are fully exploited to drive the robust optimization, while the proposed metric measures the robustness of the solutions during the process Further improvements are achieved by problem based local search and route based local search strategies Several robust optimization benchmarks, where perturbations are applied to selected problems, demonstrate that our proposed algorithm can generate sufficiently robust solutions and ensure their optimality.
Use of AI-based Platforms in Teaching and Learning of General English Writing for College EFL Learners
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yi Jyi-yeon , Kim Youngsook
Published: April 2023

Objectives The present study aimed to find out the characteristics of English writing and learners' perception of the use of AI-based platforms after having university EFL learners use AI-based platforms in the English writing teaching and learning process.
Methods In the 2nd semester of 2022, AI-based English writing scoring/English grammar check platform and machine translation platform were used for the English writing process for 20 students in a general English required course in C university. The English composition drafts in 3rd week (pre-test) and 15th week(post-test) were constructed as a learner corpus and were analyzed by Text Inspector and Jamovi 2.3.21. In addition, a survey and reflection writings were used to investigate learners' perceptions of learning English writing using AI-based platforms.
Results As a result of analyzing the corpus of pre- and post-test, a significant improvement was shown only in terms of vocabulary diversity in English writing, and no significant difference was shown in quantitative improvement such as the number of sentences and sentence length. In addition, learners were positively aware of the effectiveness of English writing teaching and learning using AI-based platforms, and in particular, reported that it was very helpful in reducing the burden of using English, which has a positive effect on the affective aspect of using AI-based platforms.
Conclusions Based on these results, it is suggested that guidance for learners, improvement of instructors' awareness, and teaching ability are necessary for the effectiveness of using AI platform and its proper use in English writing teaching and learning.
Secondary Social Studies Teachers' Perception and Training Demand for AI-based Education
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Soyoung , Lee Sang-Il , Kim Se-Chang
Published: April 2023

Objectives This study aims to investigate the attitudes and beliefs of secondary social studies teachers towards AI-based education and to assess their demand for training in this area.
Methods To this end, a survey was administered to 1,164 middle and high school social studies teachers (civics, history, geography, and ethics). The survey consists of two parts: learning about AI (learning elements of AI and capabilities of AI) and learning with AI (difficulties of teaching with AI and demand for teacher training in AI-based education). First, the reliability coefficient of the questionary items was calculated, followed by descriptive statistical analysis. To verify the statistical significance of dfferences by teachers’ specialty, a one-way analysis of variance was performed, and the effect size was calculated to confirm the practical significance. For descriptive answers, the word frequency was calculated and visualized in a word cloud to identify prominent issues.
Results 1) It was discovered that social studies teachers consider AI's social impact, machine learning, and data as crucial learning components. Particularly, teachers believed that students should be aware of artificial intelligence's technical limitations and ethical implications. 2) Assuming the class situation, the teachers indicated that the greatest anticipated challenge would be the lack of ‘exemplary practices for social studies classes using AI’. 3) Despite the fact that few teachers have prior experience with coding or AI training, 71.2% of all respondents agreed that teacher training program in AI-based education is necessary.
Conclusions This study is anticipated to serve as a foundation for the development of AI-based training programs and the introduction of AI in education.
Acute peritoneal dialysis in children (indication and complication)
Authors: Alajrish Ali Adnan Nabat , Alwasity Abbas Khudhair Abbas , Alajrish Ahmad Adnan Nabat
Published: April 2023

Objectives: The aim of this study was to review the Indications and complications Acute peritoneal dialysis.

Method: A descriptive study was performed in pediatric central teaching hospital in Baghdad City on fifty-nine cases was admitted for peritoneal dialysis for different reasons.

Results: show that the pre renal causes of PD was the most common cause which represent more than sixty percent followed by chronic renal failure and other causes, acute gastroenteritis as a cause of renal failure is most commonly seen in the first four years of life while calculi mostly seen after age of two years, sepsis is seen in the first two years of life,  Catheter blockage was the most common complication followed by bleeding and other complications, Indications for acute peritoneal dialysis in the study group uremic symptom and  oliguria was the most common indications , male to female incidence is nearly equal.

Conclusion: PD was the most common cause of CKD, chronic renal failure, acute gastroenteritis, sepsis and catheter blockage was the most common complication followed by bleeding and other complications.
Social conditioning of reproductive behavior of the population
Authors:   The Pacific State University, Gareeva I. A.
Published: April 2023

The article presents analysis of the current demographic situation associated with the reproductive activity of population. Rosstat data, secondary studies of attitudes, behavior, opinions and attitudes of the population in relation to reproductive behavior are given. As a theoretical justification, the author relies on the theory of R. Inglehart, which is based on the idea of a cultural transition from an industrial society to a post-industrial. Another theoretical approach chosen by the author defines the role of emancipative values and implies freedom of choice and equal opportunities (K Welzel). According to the author, these are important structural elements that expand the understanding of the concept of «reproductive behavior». Reproductive behavior can be viewed from the point of view as a medical phenomenon associated with conception, childbearing and childbirth and medical impact; as a socio-political phenomenon associated with the decisions and measures of authorities at all levels to improve the demographic situation. Purpose – on the basis of a comprehensive analysis, to identify the main changes and trends in the development of the demographic situation associated with reproductive behavior, to identify factors that act both motivating and destabilizing reproductive activity of the population.
Labor market tension as an indicator of economic security of the region
Authors:   The Pacific State University, Syupova M.S. , Khalikova S.S. ,   The Russian Presidential Academy of National Economy and Public Administration, the Far-Eastern institute of management – branch of RANEPA
Published: April 2023

Labor market conditions play special role in ensuring the economic security of the country and its individual territories. On the one hand, the state of labor market has a direct impact on the level of well-being of the population and the degree of their social security, the dynamics of real production and labor productivity. On the other hand, labor market indicators are characterized by a high sensitivity to existing threats of a social, economic and demographic nature. The COVID 19 pandemic and the introduction of anti-Russian sanctions have caused serious transformations that have led to an increase in tension and formation of n the new hotbeds of vulnerability in the labor market. Examining tension as the indicator of economic security of the region, this article highlights the threats that arise as a result of imbalance in the regional labor market (open unemployment, stagnant unemployment. Along with this, the article considers factors that increase stress.
Zones of coordination of corporate and regional interests of construction business companies in the regional economy
Authors:   The Real Estate Agency “Menshen”, Romashin A.A.
Published: April 2023

The article substantiates the need to coordinate interests of all participants of economic activity in the regional economy. Indicators characterizing the financial stability of companies and efficiency of the construction business organizations in the region have been identified. An integral indicator of financial stability of the construction companies and the integral indicator of the regional efficiency of these business structures were calculated on the example of the Moscow region. As a result, a map of zones of coordination of corporate and regional interests of the construction companies in the modern economy was compiled
Las ciencias sociales en América Latina la imposibilidad de un campo académico
Authors: Ruiz Patiño Jorge Humberto
Published: April 2023

El artículo presenta una reflexión sobre el proceso de constitución de las ciencias sociales latinoamericanas en las condiciones actuales de producción de conocimiento. Se aborda el modo como se han configurado las ciencias sociales en América Latina a partir de las preguntas y problemas centrales que se plantean, la definición de sus objetos de observación y las tensiones en los procesos contemporáneos de institu-cionalización. Tres preguntas orientan la argumentación general: 1. ¿Cuál puede ser la noción articuladora de las ciencias sociales en la actualidad? 2. ¿Cómo está constitui-do hoy el campo de observación de las ciencias sociales latinoamericanas? 3. ¿Cuál es la zona de convergencia que en la actualidad permitiría reinstitucionalizar las ciencias sociales latinoamericanas? Para responder las preguntas se realizó un análisis docu-mental a partir de una selección de documentos que de forma indicativa permiten obtener una imagen cercana del campo actual de las ciencias sociales en América La-tina. Se concluye quelas ciencias sociales en América Latina se caracterizan por la inexistencia de una única noción articuladora, un campo de observación definido por la relación acción colectiva-régimen político-modelo económico, y por la necesidad de buscar áreas de convergencia múltiples que excedan al Estado como actor central.
Expression of SmATPDases in Schistosoma mansoni eggs favors IL-10 mediated modulation in infected individuals
Authors: Leite Pauline Martins , Gomides Thalisson Artur Ribeiro , Souza Márcio Luís Moreira de , Figueiredo Amanda Braga de , Lima Marlucy Rodrigues , Silveira Alda Maria Soares , Assis Girley Francisco Machado de , Fraga Lúcia Alves Oliveira , Silveira-Nunes Gabriela , Martucci Letícia , Garcia Jennifer Delgado , Afonso Luís Carlos Crocco , Teixeira-Carvalho Andrea
Published: April 2023

Background and objectives: A role of IL-10 is down-regulating T
cell responses to schistosome antigens. Since SmATPDases can be
correlated to modulation of the immune response, we evaluated the
expression of enzymes in S.mansoni eggs.
Patients/Methods: Fecal samples were collected from 40 infected
individuals to detect coding regions of the SmATPDases. The cytokines
was measured in supernatants of PBMC. The analysis was performed by the
global median determination and set up high producers (HP) of cytokines.
Results: Six individuals expressed SmATPDase1, six expressed
SmATPDase2, and six expressed both enzymes. The group who expressed only
SmATPDase1 showed a high frequency of IFN-γ, TNF, IL-4 HP, individuals
who expressed only SmATPDase2 showed a high frequency of IFN-γ, IL-6,
and IL-4 HP and individuals who expressed both enzymes showed a high
frequency of IL-10 HP. In the group that showed expression both enzymes
was observed lower indices the ratio between IFN-γ/IL-10. The positive
correlation between infection intensity and IL-10 levels remained only
in the positive SmATPDase group. The IL-10 is the only cytokine induced
by the expression of both enzymes. Conclusions: The expression
of both enzymes seems to be a factor that modulates the host immune
response by inducing high IL-10 production.
Room for improvement in current influenza vaccines? A systematic literature review on the humanistic and economic burden of influenza in older (≥65 years old) adults
Authors: Langer Jakob , Welch Verna , Moran Mary , Cane Alejandro , Lopez Santiago , Srivastava Amit , Enstone Ashley , Sears Amy , Markus Kristen , Heuser Maria , Kewley Rachel , Whittle Isabelle
Published: April 2023

Introduction: Adults aged ≥65 years contribute a large proportion of
influenza-related hospitalizations and deaths due to increased risk of
complications, which result in high medical costs and reduced
health-related quality of life (HRQoL). Although seasonal influenza
vaccines are recommended for older adults, the effectiveness of current
vaccines is dependent on several factors including strain matching and
recipient demographic factors. Objective: This systemic literature
review aimed to explore the economic and humanistic burden of influenza
in adults aged ≥65 years. Methods: An electronic database search was
conducted to identify studies assessing the economic and humanistic
burden of influenza, including influenza symptoms that impact the HRQoL
and patient related outcomes in adults aged ≥65 years. Studies were to
be published in English and conducted in Germany, France, Spain, and
Italy, United Kingdom, United States, Canada, China, Japan, Brazil,
Saudi Arabia, and South Africa. Results: Twenty-five studies reported on
the economic and humanistic burden of influenza in adults aged ≥65
years. Higher direct costs were reported for people at increased-risk of
influenza-related complications compared to those at low-risk. Lower
influenza-related total costs were found in those vaccinated with
adjuvanted inactivated trivalent influenza vaccine (aTIV) compared to
high-dose trivalent influenza vaccine (TIV-HD). Older age was associated
with an increased occurrence and longer duration of certain influenza
symptoms. Despite the limited data identified for, results show that
influenza exerts a high humanistic and economic burden. in older adults.
Further research is required to confirm findings and to identify the
unmet needs of current vaccines.
A 840μm2 557nW all-MOS temperature sensor front-end for SoC thermal monitoring
Authors: Li Hao , Su Yuquan , Kong Dezhu , Yin Aiguo , Peng Jibing , Yang Zhao , Zhang Peiyong
Published: April 2023

This letter presents an 840μm2 557nW temperature sensor front-end
designed for SoC thermal monitoring. The circuit is implemented using
MOS transistors exclusively, which enhances its scalability with process
technologies and compatibility with digital circuit processes. To
address MOSFETs circuit’s process variation issues, a differential
voltage readout scheme is employed. Dynamic element matching is used to
minimize mismatch of the circuit. The sensor is self-referenced,
eliminating the need for an external reference voltage. It is prototyped
in a 55nm technology, and the measurement results showed an error of
-3.9/3.4°C across 40 samples over a temperature range of 0°C to 90°C
without calibration. After a low-cost one-point calibration at room
temperature, the error was further reduced to -1.4/1.8°C.
Waning of SARS-Cov-2 vaccine effectiveness against delta variant in COPD patients
Authors: Polivka Lorinc , Valyi-Nagy Istvan , Szekanecz Zoltan , Bogos Krisztina , Vago Hajnalka , Kamondi Anita , Fekete Ferenc , Szlavik Janos , Surjan György , Surlyan Orsolya , Nagy Peter , Schaff Zsuzsa , Kiss Zoltan , Müller Cecilia , Kasler Miklos , Müller Veronika
Published: April 2023

Although, the COVID-19 pandemic is profoundly changing, data on the
effect of vaccination and duration of protection can still be
advantageous, especially for patients with COPD, who are more vulnerable
to respiratory infections. The Hungarian-COVID-19 registry was
retrospectively investigated for vaccine effectiveness (VE) and daily
risk for infection and hospitalization by time since the last
vaccination and vaccine type in adults with COPD diagnosis and an
exact-matched control group during the Delta VOC wave in Hungary. For
the matching sex, age, major comorbidities, vaccination status, and
prior infection was used on August 23, 2021. The study population
included 373 962 cases divided into COPD patients (age: 66.67±12.66) and
a 1:1 matched group (age: 66.73±12.67). In both groups, the female/male
ratio was 52.2:47.7. There was no significant difference between the
groups in daily risks for infection or hospitalization among the
unvaccinated. Regarding vaccinated cases, a faster decline of
effectiveness was noted for hospitalization prevention in the COPD group
regardless of vaccine type. The VE reduction in this group was from
90.1% (mRNA) and 87.8% (other) to 48.8% and 34.1% respectively in
180 days. Based on the time-stratified multivariate Cox analysis of the
vaccinated cases, the hazard ratio was 1.09 (95% CI: 1.05-1.14) for
infection and 1.87 (95% CI: 1.59-2.19) for hospitalization in the COPD
group. Based on our study COPD patients are at higher risk for SARS-Cov2
VE waning and have altogether a higher risk for infection and need for
hospitalization emphasizing suggestion for revaccination measures in
this patient population.
High energy expenditure at the core of a seabird’s winter range: metabolic mechanisms for range limits
Authors: Léandri-Breton Don-Jean , Elliott Kyle , Tarroux Arnaud , Legagneux Pierre , Jouanneau William , Amélineau Françoise , Angelier Frédéric , Blévin Pierre , Bråthen Vegard , Fauchald Per , Goutte Aurélie , Tartu Sabrina , Moe B. , Chastel Olivier
Published: April 2023

Understanding how geographic range limits are shaped is a central and
challenging question in ecology that has become particularly critical in
the context of global environmental changes. A central hypothesis in
several theories for range limitations is that the density, fitness and
performance of individuals decrease towards the edge of the range as
organisms become maladapted when approaching the limit of their
environmental tolerance (‘Abundant-centre Hypothesis’). Energy is a
critical resource, especially in winter when environmental conditions
deteriorate, and this hypothesis predicts that high energy expenditure
(low performance) at the range limit would lead to rapidly dwindling
body mass and reduced fitness. We investigated this hypothesis in an
Arctic breeding seabird wintering in the North-Atlantic, the
black-legged kittiwake (Rissa tridactyla). From 2008 to 2019, we tracked
118 adult kittiwakes (n= 178 tracks) with geolocation devices and
saltwater immersion sensors to estimate the time-activity budget and
energy expenditure of individuals during winter, and estimated their
reproductive success after their return to the colony during summer.
Density was indeed higher towards the center of the range. However,
contrary to the predictions, the energy expenditure of individuals was
higher at the centre of the range and decreased towards the edge. In
contrast, there were no spatial differences in the reproductive success
of individuals wintering at the centre versus at the edge of their
range. We conclude that performance and fitness did not increase towards
the centre of the range, implying that although resource acquisition was
likely higher at the abundant centre, energy expenditure was also
higher, so that individual fitness was constant across the range.
Alien bird species decrease the diversity of bird communities across human-disturbed landscapes
Authors: Marcolin Fabio , Segurado Pedro , Chamberlain Daniel , Reino Luis
Published: April 2023

Introduced alien species have direct and indirect effects on native
communities, leading to lower taxonomic diversity and negative impacts
on ecosystem functioning. Moreover, other aspects of diversity could be
negatively affected, through alteration of functional and phylogenetic
diversity of a community. This is particularly evident in habitats where
human disturbance may favour alien species, posing an additional
stressor on native communities. Following the community resistance
hypothesis (higher diversity, higher resistance to invasion), we
hypothesized: i) higher taxonomic, functional and phylogenetic diversity
(TD, FD and PD respectively) in non-invaded bird communities (i.e. no
alien bird species); and, ii) lower alien species impact on all
diversity metrics in less human-disturbed areas. We surveyed bird
communities in a modified Mediterranean landscape subject to varying
levels of human disturbance. We tested whether TD, FD and PD indices
were significantly different between non-invaded and invaded bird
communities, and assessed the effect of landscape composition and
configuration on these indices. We found that non-invaded communities
retained higher TD and FD than invaded communities. Alien birds occupied
novel parts of the functional space in invaded communities, but that
they did not fully compensate for the taxonomic and functional diversity
loss caused by the absence of native species. These results were
consistent across different habitats, suggesting weak environmental
filtering of communities. Generally, both communities were negatively
affected by more human-disturbed areas (e.g. agriculture and urban
areas) and enhanced by forest areas and by landscape heterogeneity. Our
results suggest that the occurrence of alien birds negatively affects TD
and FD (but not PD) of bird community assemblages, but that this impact
is stronger in human-modified landscapes. Therefore, since the
conservation of biodiversity in anthropogenic habitats is a worldwide
challenge, researchers should prioritize efforts to assess the effects
of alien species on communities inhabiting those habitats.
Identification of a human blood biomarker of pharmacological 11β-hydroxysteroid dehydrogenase 1 inhibition
Authors: Castella Cristina Gómez , Alimajstorovic Zerin , Othonos Nantia , Winter Denise , White Sarah , Lavery Gareth , Tomlinson Jeremy , Sinclair Alexandra J. , Odermatt Alex
Published: April 2023

Background and Purpose: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)
catalyzes the oxoreduction of cortisone to cortisol, thereby amplifying
levels of active glucocorticoids. It is considered a pharmaceutical
target in metabolic disease and cognitive impairments. 11β-HSD1 also
converts some 7oxo-steroids to their 7β-hydroxy forms. A recent study in
mice described the ratio of tauroursodeoxycholic acid
(TUDCA)/tauro-7oxolithocholic acid (T7oxoLCA) as a biomarker for
decreased 11β-HSD1 oxoreductase activity. The present study aimed to
evaluate the equivalent bile acid ratio glycoursodeoxycholic acid
(GUDCA)/glyco-7oxolithocholic acid (G7oxoLCA) as a biomarker for
pharmacological 11β-HSD1 inhibition in humans and compare it with the
currently applied urinary
(5α-tetrahydrocortisol+tetrahydrocortisol)/tetrahydrocortisone
((5αTHF+THF)/THE) ratio. Experimental Approach: Bile acid profiles were
analyzed by ultra-HPLC tandem-MS in blood samples from two independent,
double-blind placebo-controlled clinical studies on the orally
administered selective 11β-HSD1 inhibitor AZD4017. The blood
GUDCA/G7oxoLCA ratio was compared with the urinary
tetrahydro-glucocorticoid ratio for the ability to detect 11β-HSD1
inhibition. Key Results: No significant alterations were observed in the
bile acid profiles following 11β-HSD1 inhibition by AZD4017, except for
an increase of the secondary bile acid G7oxoLCA. The enzyme
product/substrate ratio GUDCA/G7oxoLCA was found to be more reliable to
detect 11β-HSD1 inhibition than the absolute G7oxoLCA concentration in
both cohorts. Comparison of the blood GUDCA/G7oxoLCA ratio with the
urinary (5αTHF+THF)/THE ratio revealed that both ratios successfully
detect 11β-HSD1 inhibition. Conclusion and Implications: 11β-HSD1
inhibition does not cause major alterations in bile acid homeostasis.
The GUDCA/G7oxoLCA ratio represents the first blood biomarker of
pharmacological 11β-HSD1 inhibition and may replace or complement the
urinary (5αTHF+THF)/THE ratio biomarker.
Seismic reliability analysis of soil slope based on Newmark sliding block model with representative slip surfaces and response surfaces
Authors: Yu Guangming , Li Chunli , Li Liang , Yu Hongbiao
Published: April 2023

This paper presents a framework combining Monte Carlo Simulation (MCS)
and the Newmark sliding block model with Representative slip surfaces
(RSS) (model II) and Multiple response surfaces method (MRSM) to conduct
seismic reliability analysis and risk assessment of soil slopes. An
empirical threshold is introduced to define the limit state function to
identify the failure samples in MCS and the sliding area and Newmark
sliding displacement are multiplied to quantify the failure consequence.
The proposed methodology is illustrated through a soil slope with
multiple layers. The calculation results demonstrate that traditional
Newmark sliding block model (model I) tend to underestimate the
variations of yield acceleration. Both the failure probability and
landslide risk exhibit decreasing trends with the increase of threshold.
Significant discrepancy in failure probability and landslide risk
between two models is found even for a small threshold. It is therefore,
the proposed methodology is highly recommended in seismic reliability
analysis and risk assessment. The contributions of RSSs to the failure
probability and landslide risk are insensitive to the variation of
displacement thresholds.
RNA imaging in live cells
Authors: Zhao Jingfang , Xiang Limin
Published: April 2023

Traditional molecular biology tools have elucidated the identities and
functions of RNA molecules, which are essential to the understanding of
gene transcription and protein translation. Deepening this research
field would further require the direct visualization of RNA dynamics
such as the DNA-RNA interactions and RNA-protein interactions. Towards
this goal, the rise of RNA imaging tools over the past 15 years has
reformed how we looked at these processes. In this emerging topic, we
first highlighted recent advances on three main RNA imaging tools based
on the species of interacting molecules: RNA-RNA pairing, RNA-protein
binding, and small molecule-RNA complex. We introduced the advantages of
these tools from a technical viewpoint, including binding affinity,
fluorescent turn-on ratio, stability, and impacts on targeted RNA. Next,
we discussed new rising opportunities and future directions, echoing the
state-of-the-art imaging tools in the fields of fluorescent proteins and
small fluorescent molecules. Together, we believe this emerging field
will bring new insights on how we study RNA biology in living systems.