Population Pharmacokinetics of Dolutegravir in African Children: Results From the CHAPAS-4 Trial
Authors: Waalewijn Hylke , Wasmann Roeland E , Bamford Alasdair , Gibb Diana M , McIlleron Helen M , Colbers Angela , Burger David M , Denti Paolo ,   the CHAPAS-4 trial team, Gibb Di , Walker Sarah , Turkova Anna , Shakeshaft Clare , Spyer Moira , Thomason Margaret , Griffiths Anna , Monkiewicz Lara , Massingham Sue , Szubert Alex , Bamford Alasdair , Doerholt Katja , Bigault Amanda , Dudakia Nimisha , South Annabelle , Van Looy Nadine , Au Carly , Sweeney Hannah , Kityo Cissy M , Musiime Victor , Natukunda Eva , Nambi Esether , Rutebarika Antonia Diana , Nazzinda Rashida , Namyalo Imelda , Nangiya Joan , Nabeeta Lilian , Nakalyango Aidah , Kobusingye Lilian , Otike Caroline , Namala Winnie , Ampaire Phionah , Edgar Ayesiga , Nasaazi Claire , Ndigendawani Milly , Ociti Paul , Kyobutungi Priscilla , Mbabazi Ritah , Mwesigwa Rubondo Phyllis , Ankunda Juliet , Naabalamba Mariam , Nannungi Mary , Musiime Alex , Mbasani Faith , Enoch Louis Babu , Namusanje Josephine , Odoch Denis , Bagirigomwa Edward , Rubanga Eddie , Mulima Disan , Oronon Paul , David Williams Eram , Baliruno David , Kobusingye Josephine , Uyungrwoth Agnes , Mukanza Barbara , Okello Jimmy , Ninsiima Emily , Ezra Lutaro , Nambi Christine , Mangadalen Nansaigi , Sharif Musumba , Serunjogi Nobert B , Thomas Otim , Lugemwa Abbas , Makumbi Shafic , Musumba Sharif , Mawejje Edward , Yawe Ibrahim , Jovia Kyomuhendo Linda , Kasozi Mariam , Ankunda Rogers , kariisa Samson , Inyakuwa Christine , Ninsiima Emily , Atwine Lorna , Tumusiime Beatrice , Ahuura John , Tukwasibwe Deogracious , Nagasha Violet , Kukundakwe Judith , Zahara Nakisekka Mariam , Winnie Nambejja Ritah , Tukamushaba Mercy , Baker Rubinga , Keminyeto Edridah , Ainebyoona Barbara , Myalo Sula , Acen Juliet , Jinta Wangwe Nicholas , Natuhurira Ian , Kananura Natukunatsa Gershom , Mulenga Veronica , Chabala Chishala , Chipili Lungu Joyce , Kapasa Monica , Zyambo Khonzya , Zimba Kevin , Zangata Dorothy , shingalili Ellen , Mumba Naomi , kaonga Nayunda , Kabesha Mukumbi , Mwenechanya Oliver , Chipoya Terrence , Manakalanga Friday , Malama Stephen , Chola Daniel , Nduna Bwendo , Mwamabazi Mwate , Banda Kabwe , Kabamba Beatrice , Inambao Muleya , Mahy Mukandila Pauline , Nachamba Mwizukanji , Himabala Stella , Ngosa Shadrick , Sondashi Davies , Banda Collins , Munyangabe Mark , Mbewe Ngoma Grace , Chimfwembe Sarah , Lukonde Malasha Mercy , Kajimalwendo Mumba , Musukwa Henry , Mumba Shadrick , Hakim James , Bwakura-Dangarembizi Mutsa , Nathoo Kusum , Kamuzungu Taneal , Chidziva Ennie , Bhiri Joyline , Choga Joshua , Angela Mujuru Hilda , Musoro Godfrey , Mumbiro Vivian , Chitsamatanga Moses , Mutata Constantine , Zimunhu Rudo , Mudzingwa Shepherd , Gondo Secrecy , Moyo Columbus , Nhema Ruth , Boyd Kathryn , Matimba Farai , Kouamou Vinie , Matarise Richard , Tangwena Zorodzai , Mudzviti Taona , Matubu Allen , Kateta Alfred , Chinembiri Victor , Mukura Dorinda , Chimanzi Joy , Murungu Dorothy , Mapfumo Wendy , Ngwaru Pia , Chivere Lynette , Dube Prosper , Mukanganiki Trust , Weza Sibusisiwe , Gwenzi Tsitsi , Mutsai Shirley , Phiri Misheck , Ndlovu Makhosonke , Gwaze Tapiwa , Chitongo Stuart , Njaravani Winisayi , Musarurwa Sandra , Langa Cleopatra , Tafeni Sue , Ishemunyoro Wilbert , Mudzimirema Nathalie , Ndebele Wedu , Nyathi Mary , Siziba Grace , Tawodzera Getrude , Makuchete Tracey , Chidarura Takudzwa , Murangandi Shingaidzo , Mafaro Lawrence , Chivima Owen , Dumani Sifiso , Mampondo Beaullar , Maphosa Constance , Mwale Debra , Dhlamini Rangarirai , Sibanda Thabani , Madubeko Nobukhosi , Nyathi Silibaziso , Matiwaza Zibusiso , Nabukenya Sylvia , Tibakabikoba Harriet , Nakalanzi Sarah , Williams Cynthia , Chandiwana Precious , Gozhora Winnie , Dube Benedictor , Mulambo Sylvia , Mwanyungwi Hope , Burger David , Colbers Angela , Waalewijn Hylke , Bevers Lisanne , Mohsenian-Naghani Shaghayegh , McIlleron Helen , Norman Jennifer , Wiesner Lubbe , Wasmann Roeland , Denti Paolo , Tsirizani Galileya Lufina , Natukunda Eva , Musiime Victor , Musoke Phillipa , Revill Paul , Walker Simon , Kekitiinwa Adeodata , Mushavi Angela , Banda Kawamya Febby , Tindyebwa Denis , Lyall Hermione , Weller Ian , Peto Tim , Musoke Philippa , Siwale Margaret , Kambarami Rose , Roth Johanna , Beattie Pauline 
Published: July 2024

We characterized population pharmacokinetics in 42 African children receiving once-daily 25 mg (14 to &lt;20 kg) or 50 mg (&gt;20 kg) dolutegravir. Coadministration with emtricitabine and tenofovir alafenamide reduced dolutegravir bioavailability by 19.6% (95% confidence interval: 8.13%–30.8%) compared with zidovudine or abacavir with lamivudine. Nevertheless, concentrations remained above efficacy targets, confirming current dosing recommendations.