HOP-PLANT CARBONATE EXTRACT. TOXICITY. ORGANIC CHANGES
Authors:   State Institution «І. Меchnikov Іnstitute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine», Moiseienko Tetiana , Khrystian Gennadiy ,   State Institution «І. Меchnikov Іnstitute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine», Torianyk Inna ,   State Institution «І. Меchnikov Іnstitute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine»
Published: December 2020

Acne is a leading player in the spread of skin diseases. Epidemiological studies conducted in industrialised Western countries have estimated the prevalence of acne in adolescents at between 50% and 95%, depending on the method used to calculate the lesions. Acne, a disease that most often befalls teenage faces, occurs in children after the onset of adrenal and gland androgens production and subsides after growth. However, it may continue to manifest itself in a large proportion of adults, especially women. Even after recovery, negative effects such as scars and pigment spots remain. Acne (L.70, eels, ICD-10) is a chronic polymorphic multifactorial inflammatory disease of the sebaceous glands and periglandular tissue that develops mainly in young people. To date, the causes of etiopathogenesis of BX have not been sufficiently investigated. According to ICD-10, the following factors are important in the development of the disease: 1) increase in skin fat production 2) excessive follicular hyperkeratosis; 3) microflora (Propionibacterium acnes) influence 4) inflammation development. Patients suffering from acne have significantly increased skin fat production, which is usually correlated with the severity of the disease. Changes in the physiological state of the seborrhea glands, which is the basis of seborrhea, develop under the influence of neuroendocrine system dysfunction. Hyperplasia and sebaceous gland hyper-secreting occur, the physical and chemical composition of seborrhea changes and its bactericidal properties are reduced. The imbalance of the autonomic nervous system is important, which leads to a temporary or permanent increase in the tone of the vagus innervation of the sebaceous glands and, as a result, hyperproduction of sebum. A number of researchers consider follicular hyperkeratosis to be one of the leading links in the pathogenesis of acne. The aim of the study was to study the chronic toxicity of a gel with an extract of carbon dioxide hops and to determine the effect of the latter on organ changes in laboratory animals. The methodological basis was microbiological, cultural, morphological and biochemical research methods. The duration of observation was 30 days. Both experimental prototypes of gel preparations and placebo were studied in the study groups. The results in the experiments were compared with intact controls. In an animal experiment (laboratory rats), it was found that gels with carbon dioxide hop extract do not exhibit toxic (chronic) effects on the body. Dynamics of the body mass of the individuals studied, blood parameters, including the constituent elements of the blood serum, CNS functioning parameters, structural and functional state of the urine and kidney systems are the objective evidence base for the use of the medicinal substance after the clinical stage of the studies. Based on the results of a pathomorphological study of the internal organs of experimental animals, it was established that the acne gel for long-term use in the studied dose does not affect the relative mass of the internal organs of rats and does not cause morphological and functional changes in them, does not lead to inflammatory reactions, destructive and degenerative processes and necrosis. Thus, the results of this study provide the basis for the treatment of acne with mudflow medications through their prolonged use. It has been determined that the gel does not have toxic effects on the skin and does not lead to negative effects on the internal organs of animals.