bluuebunny/crossref_metadata_2025 huggingface dataset:
Hyperuricemia has increased the risk of progression of chronic kidney disease: propensity score matching analysis from the KNOW-CKD study
Authors: Oh Tae Ryom , Choi Hong Sang , Kim Chang Seong , Bae Eun Hui , Ma Seong Kwon , Sung Su-Ah , Kim Yong-Soo , Oh Kook Hwan , Ahn Curie , Kim Soo Wan
Published: April 2019

The prevalence of hyperuricemia and chronic kidney disease (CKD) has been steadily increasing. The role of hyperuricemia and efficacy of uric acid-lowering agents against CKD progression remain controversial. This study aimed to evaluate the effect of hyperuricemia and uric acid-lowering agents on the progression of CKD. A total 2042 patients with CKD were analyzed in the KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD), a prospective cohort study. Patients were classified into quartiles on the basis of their serum uric acid level and the prevalence of advanced CKD was higher in patients with a high uric acid level. A composite renal outcome was defined as one or more of the following: initiation of dialysis or transplantation, a two-fold increase in baseline serum creatinine levels, or a 50% decline in the estimated glomerular filtration rate during the follow-up period. A Cox proportional hazard ratio model was applied to analyze the relationship between composite renal outcome and uric acid levels. The risk of progression to renal failure increased by 28% (hazard ratio [HR], 1.277; 95% confidence interval [CI], 1.212–1.345) for each 1 mg/dl increase in the baseline uric acid level. In multivariate models, an association was found between the highest quartile of uric acid and increased risk of composite renal outcome (HR, 3.590; 95% CI, 2.546–5.063). A propensity score matching analysis was performed to survey the effect of uric acid lowering agent. Both allopurinol and febuxostat did not affect the renal outcome. In conclusion, hyperuricemia appears to be an independent risk factor for composite renal outcome, but allopurinol and febuxostat did not show reno-protective effect.
Probing the Transfer of the Exchange Bias Effect by Polarized Neutron Reflectometry
Authors: Zhan X. Z. , Li G. , Cai J. W. , Zhu T. , Cooper J. F. K. , Kinane C. J. , Langridge S.
Published: April 2019

The magnetic reversal behavior of a ferromagnet (FM) coupled through an FeMn antiferromagnet (AF) to a pinned ferromagnet has been investigated by polarized neutron reflectivity measurements. With FeMn as the AF layer it is found that there exists 90° interlayer coupling through this layer and that this plays a key role in the transfer of the exchange bias (EB) effect from the FM/AF interface to the AF/pinned-FM interface. Combined with Monte Carlo simulations, we demonstrate that the competition between the interlayer coupling and the anisotropy of the AF layer results in a control of the EB effect which has potential for device applications.
The influence of organically intercalated montmorillonites on the interfacial tension and structure of oil-in-water nanoemulsions
Authors: Peng Fangfang , Ke Yangchuan , Zhao Yi , Hu Xu , Zhao Xi
Published: April 2019

The amphipathic nature of the organically intercalated montmorillonites will influence their adsorption properties on the emulsion, and thus make the oil/emulsion interfacial tension quite different.
A cellular automaton for modeling non-trivial biomembrane ruptures
Authors: Gupta Abhay , Gözen Irep , Taylor Michael
Published: April 2019

A cellular automaton capturing experimentally observed floral and fractal avalanche rupture morphologies in self-spreading double lipid bilayers.
Shear melting and recovery of crosslinkable cellulose nanocrystal–polymer gels
Authors: Rao Abhinav , Divoux Thibaut , McKinley Gareth H. , Hart A. John
Published: April 2019

Cellulose nanocrystals (CNC) are naturally-derived nanostructures of growing importance for the production of composites having attractive mechanical properties, and improved sustainability. Polymer–CNC composite gels display a number of the distinctive features of colloidal glasses and their response to the flow conditions encountered during processing of composites can be tuned by chemical additives.
Densely cross-linked polysiloxane dielectric for organic thin-film transistors with enhanced electrical stability
Authors: Kim Joo-Young , Lee Eun Kyung , Jung Jiyoung , Lee Don-Wook , Yun Youngjun , Chung Jong Won , Park Jeong-Il , Kim Jang-Joo
Published: April 2019

A solution-processable organic–inorganic hybrid material composed of a polysiloxane urethane acrylate composite (PSUAC) was developed through a dual cross-linking mechanism and satisfies all the requirements for use as a gate dielectric for flexible organic thin-film transistors (OTFTs).
Determination of phosphate anions with a near-infrared heptamethine cyanine dye in a neutral aqueous solution
Authors: Gao Xia , Xu Jie , Ye Baoxian , Wu Weidong , Zheng Hong
Published: April 2019

A novel strategy was developed for the detection of phosphate anions with anionic heptamethine cyanine and Tb3+ in the NIR region.
The imaging of local glucose levels in tumor periphery via peroxyoxalate chemiluminescent nanoparticle–glucose oxidase–doped alginate hydrogel
Authors: Li Zengjin , Zhu Beibei , Duan Xinrui , Tang Wei
Published: April 2019

A simple, sensitive, and biological safety POCL–GOx–alginate/Ca gel system to detect and image local concentration of glucose in tumor periphery.
Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair
Authors: Han Chaoshan , Zhou Jin , Liang Chun , Liu Bin , Pan Xiangbin , Zhang Yu , Wang Yanli , Yan Bing , Xie Wenping , Liu Feng , Yu Xi-Yong , Li Yangxin
Published: April 2019

Stem cell-derived exosomes have been recognized as a potential therapy for cardiovascular disease.
Multiple glass transitions in vapor-deposited orientational glasses of the most fragile plastic crystal Freon 113
Authors: Vila-Costa A. , Ràfols-Ribé J. , Gonzalez-Silveira M. , Lopeandía A. , Tamarit J. Ll. , Rodríguez-Viejo J.
Published: April 2019

Stable glass formation for both structural glass and as-deposited glassy crystal at deposition temperatures below Tg.
Hydration-mediated stiffening of collective membrane dynamics by cholesterol
Authors: Päslack Christopher , Smith Jeremy C. , Heyden Matthias , Schäfer Lars V.
Published: April 2019

Hydration water governs the cholesterol-induced changes in collective headgroup dynamics in lipid bilayers.
Stanene on a SiC(0001) surface: a candidate for realizing quantum anomalous Hall effect
Authors: Li Ping
Published: April 2019

Stanene, a cousin of graphene, has pz-orbital Dirac states, but the quadratic topological states are derived from the px,yorbitals rather than pzorbital in stanene on SiC(0001).
Dual oxidase/oxygenase reactivity and resonance Raman spectra of {Cu3O2} moiety with perfluoro-t-butoxide ligands
Authors: Brazeau Sarah E. N. , Norwine Emily E. , Hannigan Steven F. , Orth Nicole , Ivanović-Burmazović Ivana , Rukser Dieter , Biebl Florian , Grimm-Lebsanft Benjamin , Praedel Gregor , Teubner Melissa , Rübhausen Michael , Liebhäuser Patricia , Rösener Thomas , Stanek Julia , Hoffmann Alexander , Herres-Pawlis Sonja , Doerrer Linda H.
Published: April 2019

A mechanism for the formation of O-donor trinuclear {Cu3O2} moiety is reported.
Nitrite reductase activity of heme and copper bound Aβ peptides
Authors: Nath Arnab Kumar , Ghosh Chandradeep , Roy Madhuparna , Seal Manas , Ghosh Dey Somdatta
Published: April 2019

The heme(III)-Cu(i)-Aβ complexes relevant to Alzheimer’s disease (AD) can reduce nitrite to nitric oxide (NO) and thus behave as nitrite reductases.
A new approach to spectroscopic and structural studies of the nano-sized silicate-substituted hydroxyapatite doped with Eu3+ ions
Authors: Targonska S. , Szyszka K. , Rewak-Soroczynska J. , Wiglusz R. J.
Published: April 2019

Nanocrystalline silicate-substituted hydroxyapatites Ca10−xEux(PO4)4(SiO4)2(OH)2 (where x = 0.5, 1.0, 2.0, 5.0 mol%) doped with Eu3+ ions were synthesized using a microwave assisted hydrothermal method and heat-treated in the temperature range from 700 to 1000 °C.
Surface intercalated spherical MoS2xSe2(1−x) nanocatalysts for highly efficient and durable hydrogen evolution reactions
Authors: Lin Bo , Lin Zhiping , Chen Shougang , Yu Meiyan , Li Wen , Gao Qiang , Dong Mengyao , Shao Qian , Wu Shide , Ding Tao , Guo Zhanhu
Published: April 2019

Surface intercalated spherical MoS2xSe2(1−x) nanocatalysts with large numbers of defects and edge areas phase transition, and increased surface roughness significantly improved the HER catalytic activity.
Energetic furazan-triazole hybrid with dinitromethyl and nitramino groups: decreasing sensitivity via the formation of a planar anion
Authors: Tang Yongxing , He Chunlin , Imler Gregory H. , Parrish Damon A. , Shreeve Jean'ne M.
Published: April 2019

Enlarging the skeleton containing two heterocyclic five-membered rings can decrease sensitivity in comparison with most highly nitro-functionalized mono nitrogen-rich rings.
Ellagic acid ameliorates AKT-driven hepatic steatosis in mice by suppressing de novo lipogenesis via the AKT/SREBP-1/FASN pathway
Authors: Zhang Cong , Hu Junjie , Sheng Lei , Yuan Ming , Wu Yong , Chen Liang , Wang Guihong , Qiu Zhenpeng
Published: April 2019

Ellagic acid alleviates hepatic lipid accumulation in mice by suppressing AKT-driven de novo lipogenesis.
Total polysaccharides of adlay bran (Coix lachryma-jobiL.) improve TNF-α induced epithelial barrier dysfunction in Caco-2 cellsviainhibition of the inflammatory response
Authors: Li Yanlong , Tian Xudong , Li Shengcai , Chang Lijun , Sun Ping , Lu Yubei , Yu Xiaoyan , Chen Shiwang , Wu Zhengquan , Xu Zhong , Kang Wanrong
Published: April 2019

Dysfunction of the intestinal epithelial barrier plays an important role in the pathogenesis of several intestinal diseases, including celiac disease, inflammatory bowel disease, and irritable bowel syndrome.
UsingDrosophilaas a platform for drug discovery from natural products in Parkinson's disease
Authors: Maitra Urmila , Ciesla Lukasz
Published: April 2019

The review provides an overview of discovery of new drug leads from natural extracts usingDrosophilaas a screening platform to evaluate the therapeutic potential of phytochemicals against Parkinson's disease.
Nanoscale distribution of TLR4 on primary human macrophages stimulated with LPS and ATI
Authors: Neumann Jan , Ziegler Kira , Gelléri Márton , Fröhlich-Nowoisky Janine , Liu Fobang , Bellinghausen Iris , Schuppan Detlef , Birk Udo , Pöschl Ulrich , Cremer Christoph , Lucas Kurt
Published: April 2019

Localization microscopy reveals donor-dependent membrane distribution of Toll-like receptor 4 (TLR4) on primary human macrophages.
Cold-swappable DNA gels
Authors: Bomboi Francesca , Caprara Debora , Fernandez-Castanon Javier , Sciortino Francesco
Published: April 2019

Experimental investigation of a designed all-DNA gel capable of swapping its linksviaa controlled toehold exchange reaction.
Real-time monitoring of pH-responsive drug release using a metal-phenolic network-functionalized upconversion nanoconstruct
Authors: Hu Feng , Liu Bei , Chu Hongqian , Liu Chang , Li Zhaohui , Chen Daquan , Li Lele
Published: April 2019

A metal-phenolic network-functionalized upconversion nanoconstruct is controllably synthesized for the monitoring of a pH-responsive drug release in real-time.
Nanoscale & Nanoscale Advances joint themed collection on halide perovskite nanocrystals
Authors: Polavarapu Lakshminarayana , Zhang Qiao , Krahne Roman
Published: April 2019

This themed issue includes a collection of articles on halide perovskite nanocrystals.
Monodisperse, sequence-defined macromolecules as a tool to evaluate the limits of ring-closing metathesis
Authors: Wetzel Katharina S. , Meier Michael A. R.
Published: April 2019

Sequence-defined macromolecules of uniform size unlock the door to many new applications in polymer chemistry, such as structure/property or structure/activity relationship investigations, which cannot be conducted accurately, if the investigated macromolecules exhibit dispersity.
Synthesis of self-healable waterborne isocyanate-free poly(hydroxyurethane)-based supramolecular networks by ionic interactions
Authors: Bossion Amaury , Olazabal Ion , Aguirresarobe Robert H. , Marina Sara , Martín Jaime , Irusta Lourdes , Taton Daniel , Sardon Haritz
Published: April 2019

A novel synthetic strategy to isocyanate-free supramolecular polyhydroxyurethanes based on ionic interactions is described.
Carbon quantum dot-covered porous Ag with enhanced activity for selective electroreduction of CO2 to CO
Authors: Gao Jin , Zhao Siqi , Guo Sijie , Wang Huibo , Sun Yue , Yao Bowen , Liu Yang , Huang Hui , Kang Zhenhui
Published: April 2019

A carbon quantum dot-covered porous Ag composite can efficiently reduce CO2 to CO.
An efficient, three-dimensional non-fullerene electron acceptor: functionalizing tetraphenylethylene with naphthalene diimides
Authors: Wagalgave Sopan M. , Bhosale Sheshanath V. , Bhosale Rajesh S. , Puyad Avinash L. , Chen Jing-Yu , Li Jing-Liang , Evans Richard A. , Gupta Akhil , Bhosale Sidhanath V.
Published: April 2019

A non-fullerene acceptor, W8, based on tetraphenylethylene and naphthalene diimide ITO/PEDOT:PSS/PTB7:W8 (1 : 1.2 D : A w/w)/Ca/Al; PCE = 8.58%.
Copper-mediated direct sulfonylation of C(sp2)–H bonds employing TosMIC as a sulfonyl source
Authors: Fan Cai-Ling , Zhang Lin-Bao , Liu Jia , Hao Xin-Qi , Niu Jun-Long , Song Mao-Ping
Published: April 2019

Cu-Mediated sulfonylation of C(sp2)–H bonds with p-tosylmethyl isocyanide (TosMIC) as a sulfonyl source was developed utilizing a removable N,O-directing group.
Oxidative radical addition–chlorination of alkenes to access 1,1-dichloroalkanes from simple reagents
Authors: Chen Cui , Li Yibiao , Pan Yupeng , Duan Linhai , Liu Weibing
Published: April 2019

This protocol provides a facile regioselective method for the synthesis of 1,1-dichloroalkanes from terminal alkenes using simple chloro reagents.
Biocatalytic oxidation of flavone analogues mediated by general biocatalysts: horseradish peroxidase and laccase
Authors: Yan Qingsong , Tang Xiaoguang , Zhang Baojing , Wang Chunjie , Deng Sa , Ma Xiaochi , Wang Chao , Li Dawei , Huang Shanshan , Dong Peipei
Published: April 2019

HRP and laccase as the oxidases have been applied to catalyze the oxidation of various flavones, and the mechanism has been investigated.
Si, Sr, Ag co-doped hydroxyapatite/TiO2coating: enhancement of its antibacterial activity and osteoinductivity
Authors: Qiao Haixia , Song Guiqin , Huang Yong , Yang Hao , Han Shuguang , Zhang Xuejiao , Wang Zhenhui , Ma Jing , Bu Xiaopei , Fu Li
Published: April 2019

A multifaceted coating with favourable cytocompatibility, osteogenic activity and antibacterial properties would be of great significance and value due to its capability for improving osseointegration and alleviating prosthesis loosening.
In vitrocytotoxicity and antibiotic application of green route surface modified ferromagnetic TiO2nanoparticles
Authors: Atique Ullah A. K. M. , Tamanna A. N. , Hossain A. , Akter M. , Kabir M. F. , Tareq A. R. M. , Fazle Kibria A. K. M. , Kurasaki Masaaki , Rahman M. M. , Khan M. N. I.
Published: April 2019

Artocarpus heterophyllusleaf extract mediated green synthesized TiO2nanoparticles exhibit less toxicity with high antibacterial activity.
Explaining the influence of the introduced base sites into alkali oxide modified CsX towards side-chain alkylation of toluene with methanol
Authors: Li Peidong , Han Qiao , Zhang Xiaomin , Yuan Yangyang , Zhang Yanfei , Xu Li , Guo Hongchen , Xu Lei
Published: April 2019

Alkali oxide modification promotes side-chain alkylation of toluene with methanol by strengthening the base properties of Oδ− in the CsX framework.
Spinel oxide CoFe2O4 grown on Ni foam as an efficient electrocatalyst for oxygen evolution reaction
Authors: Zhu Shasha , Lei Jinglei , Qin Yonghan , Zhang Lina , Lu Lijuan
Published: April 2019

The effect of the oxygen evolution reaction (OER) is important in water splitting.
Knockdown of circPVT1 inhibits progression of papillary thyroid carcinoma by sponging miR-126
Authors: Tao Ling , Yang Li , Tian Ping , Guo Xiangyang , Chen Yanping
Published: April 2019

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. Recent studies have reported that circular RNAs (circRNAs) play essential roles in human cancers, including PTC.
Development of double strand RNA mPEI nanoparticles and application in treating invasive breast cancer
Authors: Liu Rui , Mu Li-Min , Bai Jing , Du Ya-Fei , Xie Ying , Lu Wan-Liang
Published: April 2019

dsRNA mPEI nanoparticles entered cytoplasm and lysosomal escape occurred. dsRNA was released to form a dsRNA–RISC complex. Then, remaining sense strand bound to mRNA, forming a new structure. Thus, mRNA was cleared and translation was inhibited.
A photochemical and theoretical study of the triplet reactivity of furano- and pyrano-1,4-naphthoquionones towards tyrosine and tryptophan derivatives
Authors: Teixeira Rodolfo I. , Goulart Juliana S. , Corrêa Rodrigo J. , Garden Simon J. , Ferreira Sabrina B. , Netto-Ferreira José Carlos , Ferreira Vitor F. , Miro Paula , Marin M. Luisa , Miranda Miguel A. , de Lucas Nanci C.
Published: April 2019

Biologically active naphthoquinones undergo photochemical induced hydrogen abstraction from biologically relevant substratesviaa PCET mechanism.
Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells
Authors: Pewklang Thitima , Chansaenpak Kantapat , Lai Rung-Yi , Noisa Parinya , Kamkaew Anyanee
Published: April 2019

A bivalent indomethacin/Aza-BODIPY conjugate can selectively visualize the COX-2 enzyme in cancer and inflamed cells confirming its potential as a COX-2-specific biomarker in clinical applications.
The label-free detection and distinction of CYP2C9-expressing and non-expressing cells by surface-enhanced Raman scattering substrates based on bimetallic AuNPs–AgNWs
Authors: Cao Xiaowei , Chen Shuai , Wang Zhenyu , Liu Yong , Luan Xiaowei , Hou Sicong , Li Wei , Shi Hongcan
Published: April 2019

A AuNPs–AgNWs decorated silicon wafer was used as a non-destructive and label-free tool in SERS spectroscopy to detect and distinguish the cellular composition of CYP2C9-expressing cells (293T-Mig-2C9) and non-expressing cells (293T-Mig-R1).
Riboflavin-protected ultrasmall silver nanoclusters with enhanced antibacterial activity and the mechanisms
Authors: Li Xizhe , Fu Tao , Li Bingyu , Yan Peng , Wu Yayan
Published: April 2019

Riboflavin acted as a surface coating to synthesize ultrasmall silver nanoclusters and RF@AgNCs possessed highly efficient antibacterial activity and good biocompatibility.
Design and synthesis of CoIIHMTAA-14/16 macrocycles and their nano-composites for oxygen reduction electrocatalysis
Authors: Kumar Anuj , Vashistha Vinod Kumar
Published: April 2019

The major concerns in the design of macrocycle based-ORR catalysts are understanding the macrocyclic, π-conjugation, central metal and substituent effects on electrocatalysis; and their use on the electrode surface for the retention of activity due to poor stability.
Simultaneous size manipulation and red upconversion luminescence enhancement of CaF2:Yb3+/Ho3+nanoparticles by doping with Ce3+ions
Authors: Yang Xu , Yuan Maohui , Wang Rui , Zhao Xiaofan , Yang Zining , Han Kai , Wang Hongyan , Xu Xiaojun
Published: April 2019

Size manipulation and red upconversion luminescence enhancement are simultaneously realized in CaF2:Yb3+/Ho3+nanoparticles by doping with Ce3+ions.
A dynamic self-regulation actuator combined double network gel with gradient structure driven by chemical oscillating reaction
Authors: Li Jie , Li Xiuchen , Zheng Zhaohui , Ding Xiaobin
Published: April 2019

Self-regulation of the dynamic actuation of a chemical oscillating reaction-based gel was realized by altering the network structure of the gradient double network gel.
Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
Authors: Nie Hui-Jun , Guo An-Di , Lin Hai-Xia , Chen Xiao-Hua
Published: April 2019

A straightforward protocol for the rapid construction of privileged indazolone architectures suggests a new avenue of great importance to medicinal chemistry.
Tar yield and composition from poultry litter gasification in a fluidised bed reactor: effects of equivalence ratio, temperature and limestone addition
Authors: Horvat Alen , Pandey Daya Shankar , Kwapinska Marzena , Mello Barbara B. , Gómez-Barea Alberto , Fryda Lydia E. , Rabou Luc P. L. M. , Kwapinski Witold , Leahy James J.
Published: April 2019

Qualitative and quantitative measurements of tar from poultry litter gasification in an air-blown fluidised bed.
A visible-light mediated three-component radical process using dithiocarbamate anion catalysis
Authors: Cuadros Sara , Horwitz Matthew A. , Schweitzer-Chaput Bertrand , Melchiorre Paolo
Published: April 2019

A three-component radical process is reported that, by coupling alkyl chlorides, maleimides, and heteroaromatic fragments, installs multiple biologically relevant heterocycles within complex cascade products. This method, which generates radicals via an SN2-based photochemical catalytic mechanism, activates substrates incompatible with or inert to classical radical-generating strategies.
Rational design of functional materials guided by single particle chemiluminescence imaging
Authors: Kong Weijun , Li Qi , Wang Wei , Zhao Xiaoning , Jiang Shenglong , Zheng Tianhua , Zhang Qun , Shen Wen , Cui Hua
Published: April 2019

Correlated chemiluminescence imaging and structural characterization of single particles helped the rational design of functional materials with significantly improved performance.
Machine learning for renewable energy materials
Authors: Gu Geun Ho , Noh Juhwan , Kim Inkyung , Jung Yousung
Published: April 2019

Achieving the 2016 Paris agreement goal of limiting global warming below 2 °C and securing a sustainable energy future require materials innovations in renewable energy technologies. Machine learning has demonstrated many successes to accelerate the discovery renewable energy materials.
Green full polymer flexible transparent electrodes showing versatile switching behaviors based on either counterion transport or nanoarea crystallization
Authors: Liao Jingwen , Yang Mingjin , Liu Wenfeng , Zhou Yahong , Bi Xiaofeng , Yuan Hai
Published: April 2019

Based on either counterion transport or nanoarea crystallization, a green full polymer flexible transparent electrode shows versatile switching behaviors.
Understanding the effects of oxygen defects on the redox reaction pathways in LiVPO4F by combining ab initio calculations with experiments
Authors: Park Heetaek , Kim Minkyung , Kang ShinYoung , Kang Byoungwoo
Published: April 2019

Asymmetric redox reaction pathways in LiVPO4F can be understood by a presence of oxygen defects in fluorine sites.
Amphiphilic two-dimensional graphitic carbon nitride nanosheets for visible-light-driven phase-boundary photocatalysis
Authors: Yao Chengkai , Yuan Aili , Wang Zhongsen , Lei Hua , Zhang Long , Guo Limin , Dong Xiaoping
Published: April 2019

Amphiphilic two-dimensional graphitic carbon nitride nanosheets exhibit improved performance for visible-light-driven phase-boundary photocatalytic reduction of nitrobenzene to aniline.
High energy density and high efficiency all-organic polymers with enhanced dipolar polarization
Authors: Li Zongze , Treich Gregory M. , Tefferi Mattewos , Wu Chao , Nasreen Shamima , Scheirey Sydney K. , Ramprasad Rampi , Sotzing Gregory A. , Cao Yang
Published: April 2019

The dielectric constant of polymers was increased by combining flexible segments and rigid polar segments in the polymer backbone.
Polymerization induced phase separation as a generalized methodology for multi-layered hydrogel tubes
Authors: Rong Mingming , Ma Shuanhong , Lin Peng , Cai Meirong , Zheng Zijian , Zhou Feng
Published: April 2019

Herein, we report a conceptually chemical strategy to facilitate the fabrication of layered hydrogel tubes based on the polymerization-induced phase separation mechanism.
Asymmetric multifunctional 3D cell microenvironments by capillary force assembly
Authors: Song Qimeng , Druzhinin Sergey I. , Schönherr Holger
Published: April 2019

The fabrication and characterization of advanced 3D cell culture microenvironments that enable systematic structure–property relationship studies are reported.
Solid-phase synthesis of atomically thin two-dimensional non-layered MoO2 nanosheets for surface enhanced Raman spectroscopy
Authors: Lin Xiangcheng , Yan Pengfei , Xu Fafeng , Wu Wenzhuo , Hu Tianzhao , Wei Cong , Xu Qun
Published: April 2019

Atomically thin plasmonic MoO2 nanosheets were successfully obtained via a solid–solid reaction, which exhibits tremendous potential for the general fabrication of other two-dimensional nonlayered materials.
Impact of XPF rs2276466 polymorphism on cancer susceptibility: a meta-analysis
Authors: Liu Yezhou , Liu Kun , Zhao Xueru , Sun Yidan , Ma Ning , Tang Longmei , Yang Haitao , Gao Xia , Yan Lina , Yuan Meina , Wang Bingshuang , Zhang Xiaolin , Jia Jinhai
Published: April 2019

Association between the xeroderma pigmentosum complementation group F (XPF)rs2276466 located in the excision repair cross complementation group 4 (ERCC4) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility. PubMed, Embase and Science-Web databases were searched systematically up to May 20, 2018, to obtain all the records evaluating the association between the rs2276466 polymorphism and the risk of all types of cancers. We used the odds ratio (OR) as a measure of effect, and pooled the data in a Mantel-Haenszel weighed random-effects meta-analysis to provide a summary estimate of the impact of this polymorphism on gastrointestinal cancer, neurogenic cancer and other cancers (breast cancer and SCCHN). All the analyses were carried out in STATA 14.1.11 case–control studies that consisted of 5730 cases and 6756 controls, were eventually included in our meta-analysis. The significant association was observed between the XPFrs2276466 polymorphism and neurogenic cancer susceptibility (recessive model: OR = 1.648, 95% CI = 1.294–2.098, P<0.001). Furthermore, no significant impact of this polymorphism was detected on decreased gastrointestinal cancer risk (dominant model: OR = 1.064, 95%CI = 0.961–1.177, P = 0.233). The rs2276466 polymorphism might play different roles in carcinogenesis of various cancer types. Current evidence did not suggest that this polymorphism was directly associated with gastrointestinal susceptibility. However, this polymorphism might contribute to increased neurogenic cancer risk. More preclinical and epidemiological studies are still imperative for further evaluation
The Effect of Recording Montage and Tone Burst Duration on Cervical and Ocular Vestibular Evoked Myogenic Potential Latency and Amplitude
Authors: Smith Kaylee J. , McCaslin Devin L. , Jacobson Gary P. , Burkard Robert
Published: April 2019

Objectives

The objectives of this study were (a) to investigate the optimal tone burst duration when recording the cervical vestibular evoked myogenic potential (cVEMP) and the ocular vestibular evoked myogenic potential (oVEMP) and (b) to determine whether monopolar recording influences the latency or amplitude of the cVEMP or the oVEMP.

Method

Fifteen subjects (
M
= 27.7 years,
SD
= 6.73 years) participated in this study. The participants had no prior history of otological or neurological disease. Both oVEMPs and cVEMPs were recorded at a fixed stimulus level for stimulus durations of 2, 5, 10, and 25 ms. For both cVEMP and oVEMP, responses were obtained using a traditional differential recording montage and a monopolar recording montage.

Results

The cVEMP and the oVEMP had the greatest amplitude in the 2-ms stimulus condition. There was a statistically significant decrease in amplitude for durations greater than 2 ms. Monopolar and bipolar cVEMP and oVEMP latencies and amplitudes were not significantly different.

Conclusion

As stimulus duration increased beyond 2 ms, the amplitude of the response decreased for both the cVEMP and the oVEMP. There was no significant change in latency with increasing stimulus duration for either response. These results suggested the optimal stimulus duration for both the oVEMP and cVEMP is 2 ms, and there is no apparent advantage of using a bipolar recording technique.
Systematic Review of Auditory Training in Pediatric Cochlear Implant Recipients
Authors: Rayes Hanin , Al-Malky Ghada , Vickers Deborah
Published: April 2019

Objective

The purpose of this systematic review is to evaluate the published research in auditory training (AT) for pediatric cochlear implant (CI) recipients. This review investigates whether AT in children with CIs leads to improvements in speech and language development, cognition, and/or quality of life and whether improvements, if any, remain over time post AT intervention.

Method

A systematic search of 7 databases identified 96 review articles published up until January 2017, 9 of which met the inclusion criteria. Data were extracted and independently assessed for risk of bias and quality of study against a PICOS (participants, intervention, control, outcomes, and study) framework.

Results

All studies reported improvements in trained AT tasks, including speech discrimination/identification and working memory. Retention of improvements over time was found whenever it was assessed. Transfer of learning was measured in 4 of 6 studies, which assessed generalization. Quality of life was not assessed. Overall, evidence for the included studies was deemed to be of low quality.

Conclusion

Benefits of AT were illustrated through the improvement in trained tasks, and this was observed in all reviewed studies. Transfer of improvement to other domains and also retention of benefits post AT were evident when assessed, although rarely done. However, higher quality evidence to further examine outcomes of AT in pediatric CI recipients is needed.
Unsupervised fault diagnosis method based on iterative multi‐manifold spectral clustering
Authors: Song Wenbin , Wen Long , Gao Liang , Li Xinyu
Published: April 2019

Fault diagnosis is very important to the modern manufacturing system. As a powerful data‐driven method, machine learning (ML) has been widely used for fault diagnosis. However, a certain amount of labelled data is essential to most of the ML methods, which is not always available. In this study, an unsupervised fault diagnosis method based on iterative multi‐manifold spectral clustering (IMMSC) is proposed. The IMMSC, that the affinity matrix is constructed based on local tangent space, can improve the performance of spectral clustering on multi‐manifold distributed data. The IMMSC is conducted after feature extraction to divide data into different clusters first. Then local outlier factor is utilised to identify the normal condition. A fault index is found to recognise the fault conditions. The proposed IMMSC is tested on five simulation datasets and the proposed method is validated on the motor bearing dataset provided by Case Western Reserve University. The mean accuracy of IMMSC on simulation data is 97.85%, which outperforms the other spectral clustering and traditional methods. Furthermore, the result of the IMMSC is stable over 30 individual tests. The mean accuracy of the proposed method on motor bearing dataset is 98.53%. The result demonstrates its potential in fault diagnosis field.
Distributed optimisation‐based collaborative security‐constrained transmission expansion planning for multi‐regional systems
Authors: Mehrtash Mahdi , Kargarian Amin , Mohammadi Ali
Published: April 2019

This study presents a distributed collaborative transmission expansion planning (TEP) algorithm for interconnected multi‐regional power systems. The proposed algorithm is a multi‐agent‐based TEP. A local TEP is formulated for each region (agent) with respect to the region's local characteristic and interactions (i.e. tie‐line flows) with its neighbours. Nodal power balances at border buses are modified to model the interactions. Realistic planning constraints and objectives such as budget constraints, operational costs, N − 1 security criterion, and uncertainties are modelled in the local TEPs. The information privacy is respected as each local planner needs to share limited information related to cross‐border tie lines with other planners. To coordinate the local planners, a two‐level distributed optimisation algorithm is proposed based on the concept of analytical target cascading (ATC) for multidisciplinary design optimisation. While the upper level solves the local TEPs in parallel, the lower level seeks to coordinate neighbouring regions. The lower‐level problem is further replaced in the upper‐level optimisation by Karush–Kuhn–Tucker conditions to relax the need for any form of central coordinator. This makes the proposed ATC‐based TEP a fully parallelised distributed optimisation algorithm. An initialisation strategy is suggested to enhance the performance of the distributed TEP.
Electric vehicle charging schedule considering user's charging selection from economics
Authors: Chen Jie , Huang Xiaoqing , Tian Shiming , Cao Yijia , Huang Bicheng , Luo Xiaoyue , Yu Wenlong
Published: April 2019

Electric vehicle (EV) charging will bring new challenges to the coordination of grid and EV load. To facilitate large‐scale EV applications, optimal scheduling of EVs has become essential. However, the power grid has no power to force EV users to charge or give up charging. The actual type and mode of user's charging, may deviate from the expectations of grid. When the number of deviation's EV is sufficient, the power grid schedule will not achieve the expected results. In this context, a multi‐objective scheduling method considering user's charging selection is proposed to determine the optimal EV charging. The novel contributions of this paper lie in the exploitation of the user's preferences and their criterion of charging selection in form of functions based on concepts from economics. Three types of charging preferences for EV users including radical, conservative and balanced are used to influence the charging cost of EVs and load variance of grid. Finally, the ideal scheduling and actual scheduling are used to simulate various scenarios. The extensive results show that by introducing a method considering the influence of EV user's selection, the efficacy of the proposed scheduling can be further improved.
Probabilistic deep neural network price forecasting based on residential load and wind speed predictions
Authors: Afrasiabi Mousa , Mohammadi Mohammad , Rastegar Mohammad , Kargarian Amin
Published: April 2019

Precise price forecasting can lessen the risk of participation in the deregulated electricity market. On account of a large amount of historical data, deep learning based methods can be a promising solution to achieve an accurate forecast. This study presents a deep neural network algorithm to estimate the probability density function of price, incorporating the prediction of wind speed and residential load as two other high volatile parameters. To this end, first, a combination of convolution neural network (CNN) and gated recurrent unit (GRU) is utilised to predict wind speed and residential load. Then, the results are integrated into historical price information to form the input dataset for price forecasting. The proposed price forecast procedure consists of CNN, GRU, and adaptive kernel density estimator (AKDE). AKDE is used as a numerical algorithm to capture probabilistic characterisation of real‐time and day‐ahead prices. Several deep and shallow networks and the proposed algorithm are implemented, and the results are compared. Furthermore, the effectiveness of AKDE in providing complete statistical information is verified through comparison with conventional and fixed smooth KDEs. In addition, the gradient boosting tree method is incorporated to verify the dependence of the price to the wind and the residential loads.
Application of cluster analysis in short‐term wind power forecasting model
Authors: Xu Aoran , Yang Tao , Ji Jianwei , Gao Yang , Gu Cailian
Published: April 2019

At present, the method of predicting wind power generation is mainly based on data integration calculation. Although this method is simple, it has shortcomings in short‐term and ultra‐short‐term predictions owing to low accuracy. In this study, the clustering analysis data processing method is used to pre‐process the meteorological wind power generation data, thus improving the data quality. This method builds model samples based on historical data with similar numerical weather prediction (NWP) characteristic parameters of the original sample data and forecast date, takes the NWP information of the forecast date as the basis of similarity measurement, and extracts effective data for the neural network prediction model after the improved clustering processing. Therefore, short‐term wind power prediction analysis can be performed. Herein, the proposed data processing method is combined with the neural network model to create a software product that is applied to a wind farm in northeast China. The combined clustering data processing method of the wind power prediction model improved power prediction by ∼12% compared with that of the traditional continuous model. This demonstrates an obvious improvement in the prediction accuracy, thereby further proving the validity of the proposed method.
Multilevel quasi-Monte Carlo integration with product weights for elliptic PDEs with lognormal coefficients
Authors: Herrmann L. , Schwab C.
Published: April 2019

We analyze the convergence rate of a multilevel quasi-Monte Carlo (MLQMC) Finite Element Method (FEM) for a scalar diffusion equation with log-Gaussian, isotropic coefficients in a bounded, polytopal domainD⊂ ℝd. The multilevel algorithmQL*which we analyze here was first proposed, in the case of parametric PDEs with sequences of independent, uniformly distributed parameters in Kuoet al.(Found. Comput. Math.15(2015) 411–449). The random coefficient is assumed to admit a representation withlocally supported coefficient functions, as arise for example in spline- or multiresolution representations of the input random field. The present analysis builds on and generalizes our single-level analysis in Herrmann and Schwab (Numer. Math.141(2019) 63–102). It also extends the MLQMC error analysis in Kuoet al.(Math. Comput.86(2017) 2827–2860), to locally supported basis functions in the representation of the Gaussian random field (GRF) inD, and to product weights in QMC integration. In particular, in polytopal domainsD⊂ ℝd,d=2,3, our analysis is based on weighted function spaces to describe solution regularity with respect to the spatial coordinates. These spaces allow GRFs and PDE solutions whose realizations become singular at edges and vertices ofD. This allows fornon-stationaryGRFs whose covariance operators and associated precision operator are fractional powers of elliptic differential operators inDwith boundary conditions on∂D. In the weighted function spaces inD, first order, Lagrangian Finite Elements on regular, locally refined, simplicial triangulations ofDyield optimal asymptotic convergence rates. Comparison of theε-complexity for a class of Matérn-like GRF inputs indicates, for input GRFs with low sample regularity, superior performance of the present MLQMC-FEM with locally supported representation functions over alternative representations,e.g.of Karhunen–Loève type. Our analysis yields general bounds for theε-complexity of the MLQMC algorithm, uniformly with respect to the dimension of the parameter space.
L’édition de gènes dans la découverte du médicament et l’innovation thérapeutique
Authors: Galzi Jean-Luc
Published: April 2019

On lit régulièrement dans la presse que les méthodes thérapeutiques récentes vont supplanter celles plus traditionnelles de la pharmacopée. Le biomédicament et les thérapies géniques connaissent un essor considérable, mais on s’aperçoit que chaque approche thérapeutique a ses contraintes et ses limites et que les champs thérapeutiques les plus pertinents sont le plus souvent complémentaires de ceux du médicament traditionnel, plutôt que concurrents, et bien souvent synergiques. Cette revue met en perspective les méthodes de l’édition de génomes avec celle de la découverte du médicament, dans le domaine de l’innovation thérapeutique.
Milieu Intérieur : définir les limites d’une réponse immunitaire saine pour mieux comprendre la maladie
Authors: Duffy Darragh
Published: April 2019

Un point commun de tous les individus réside dans le fait qu’ils sont justement tous différents. Certaines des plus grandes différences entre deux individus peuvent être liées à leurs réponses immunitaires, entraînant des conséquences variables face à une infection, à la gravité d’une maladie et à la réponse aux traitements médicaux. Les différences dans les réponses immunitaires reposent en partie sur des forces évolutives agissant au niveau de la génétique de l’hôte. Elles peuvent également être dues aux différences que nous rencontrons dans notre environnement et notre mode de vie. Malgré ces différences interindividuelles bien connues, cette variabilité inhérente est rarement incluse dans les approches cliniques ou le développement de médicaments.
Lipid Droplet Formation and Lipophagy in Fatty Liver Disease
Authors: Schulze Ryan J. , McNiven Mark A.
Published: April 2019

Lipid droplets (LDs) are key sites of neutral lipid storage that can be found in all cells. Metabolic imbalances between the synthesis and degradation of LDs can result in the accumulation of significant amounts of lipid deposition, a characteristic feature of hepatocytes in patients with fatty liver disease, a leading indication for liver transplant in the United States. In this review, the authors highlight new literature related to the synthesis and autophagic catabolism of LDs, discussing key proteins and machinery involved in these processes. They also discuss recent findings that have revealed novel genetic risk factors associated with LD biology that contribute to lipid retention in the diseased liver.
Macrophages as Key Players during Adipose Tissue–Liver Crosstalk in Nonalcoholic Fatty Liver Disease
Authors: Korf Hannelie , Boesch Markus , Meelberghs Lore , van der Merwe Schalk
Published: April 2019

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that could lead to serious health problems including liver failure, cancer, or death. The term NAFLD includes a spectrum of disease states with histological features ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). A key aspect within this research field is the identification of pathogenic factors that trigger inflammation, thus fueling the transition from nonalcoholic fatty liver to NASH. These inflammatory triggers may originate from within the liver as a result of innate immune cell activation and/or hepatocyte injury. Additionally, they may originate from other sites such as adipose tissue or the intestinal tract. In the current review, the authors will primarily focus on events within adipose tissue which may be of importance in triggering the disease progression. They specifically focus on the role of adipose tissue macrophages during NAFLD pathogenesis and how microenvironmental factors may shape their metabolic profile. They further dissect how redirecting the macrophage's metabolic profile alters their immunological functions. Finally, they discuss the opportunities and challenges of targeting macrophages to interfere in disease progression.
Thrombotic Complications in Gliomas
Authors: Czap Alexandra L. , Becker Ashley , Wen Patrick Y.
Published: April 2019

Arterial and venous thromboses are common in glioma patients, both in the perioperative period and throughout the course of the disease. High-grade glioma patients harbor underlying hypercoagulability, which predisposes these high-risk patients with prolonged immobility and neurologic deficits to thrombotic events. Despite the high incidence and recurrent nature of these complications, there is no standardized approach to the management of glioma patients, and many challenges remain. Historically, the perceived risk of intracranial and intratumoral hemorrhage limited the use of anticoagulation, favoring nonpharmacological prophylaxis and treatment. Multiple studies have demonstrated the safety and efficacy of anticoagulation when indicated, with low molecular weight heparin as the preferred short- or long-term treatment. This review will discuss the epidemiology, risk factors, and therapeutic management of both venous and arterial thrombotic complications in glioma.
Measurement of the non-radiative minority recombination lifetime and the effective radiative recombination coefficient in GaAs
Authors: Niemeyer M. , Kleinschmidt P. , Walker A. W. , Mundt L. E. , Timm C. , Lang R. , Hannappel T. , Lackner D.
Published: April 2019

The combination of time-resolved (TR) and power-dependent relative (PDR) photoluminescence (PL) measurements reveals the possibility of separating the radiative and non-radiative minority carrier lifetimes and measuring the sample-dependent effective radiative recombination coefficient in direct bandgap semiconductors. To demonstrate the method, measurements on 2 μm thick p-type GaAs double-hetero structures were conducted for various doping concentrations in the range of 5x1016 and 1x1018 cm-3. With a photon recycling factor of 0.76 ± 0.04 the radiative recombination coefficient was determined to be (3.3±0.6)×10-10 cm3s-1 for the structures with a doping concentration below 1*1018 cm-3, whereas the effective radiative recombination parameter for an absorber thickness of 2 μm was directly measured to be (0.78±0.07) ×10-10 cm3s-1. For a doping concentration of 1×1018 cm-3, the radiative recombination coefficient decreases significantly probably due to the degeneracy of the semiconductor.
Performance of trajectory surface hopping method in the treatment of ultrafast intersystem crossing dynamics
Authors: Peng Jiawei , Xie Yu , Hu Deping , Lan Zhenggang
Published: April 2019

We carried out extensive studies to examine the performance of the fewest-switches surface hopping method in the description of the ultrafast intersystem crossing dynamic of various singlet-triplet (S-T) models by comparison with the results of the exact full quantum dynamics. Different implementation details and some derivative approaches were examined. As expected, it is better to perform the trajectory surface hopping calculations in the spin-adiabatic representation or by the local diabatization approach, instead of in the spin-diabatic representation. The surface hopping method provides reasonable results for the short-time dynamics in the S-T model with weak spin-orbital coupling (diabatic coupling), although it does not perform well in the models with strong spin-orbital coupling (diabatic coupling). When the system accesses the S-T potential energy crossing with rather high kinetic energy, the trajectory surface hopping method tends to produce a good description of the nonadiabatic intersystem crossing dynamics. The impact of the decoherence correction on the performance of the trajectory surface hopping is system dependent. It improves the result accuracy in many cases, while its influence may also be minor for other cases.