bluuebunny/crossref_metadata_2025 huggingface dataset:
Resuming a Dynamic Task Following Increasingly Long Interruptions: The Role of Working Memory and Reconstruction
Authors: Labonté Katherine , Vachon François
Published: June 2021

Studies examining individual differences in interruption recovery have shown that higher working memory capacity (WMC) attenuated the negative impact of interruption length on resumption, at least in static contexts. In continuously evolving (or dynamic) situations, however, working memory may not be as central to the effective resumption of a task, especially in the case of long interruptions. One of the main theories of task interruption suggests that dynamic task resumption could depend on a reconstruction of the primary task context, that is, a visual examination of the post-interruption environment. To better define the role of working memory and reconstruction processes in interruption recovery, the current study examined the association between (1) dynamic task resumption following interruptions of various lengths and (2) two cognitive abilities chosen to operationalize the processes under study, namely, WMC and visual search capacity. Participants performed a multiple object tracking task which could be uninterrupted or interrupted for 5, 15, or 30 s while the hidden stimuli continued their trajectory. They also completed tasks measuring the two cognitive abilities of interest. The results revealed that WMC contributed to post-interruption accuracy regardless of interruption duration. On the contrary, visual search capacity was related to faster resumption in the 15-s and 30-s interruption conditions only. Those results show that working memory plays a preponderant role in resumption not only in static, but also in dynamic contexts. However, our study suggests that this mechanism must share the limelight with reconstruction following lengthy interruptions in dynamic settings.
Validation of a Tool to Evaluate Drug Prevention Programs Among Students
Authors: Galvão Patrícia Paiva de O. , Valente Juliana Y. , Millon Jacqueline N. , Melo Márcia H. S. , Caetano Sheila C. , Cogo-Moreira Hugo , Mari Jair J. , Sanchez Zila M.
Published: June 2021

Background: School-based prevention programs have been implemented worldwide with the intention of reducing or delaying the onset of alcohol and drug use among adolescents. However, their effects need to be evaluated, being essential to use validated and reliable questionnaires for this purpose. This study aimed to verify the semantic validity and reliability of an instrument developed to evaluate the results of a government drug prevention program for schoolchildren called #Tamojunto2.0.

Methods: This is a mixed methods study with quantitative (test-retest, confirmatory factor analysis and non-response evaluation) and qualitative analyses (focus group and field cards). The self-administered questionnaires were used for a sample of 262 eighth-grade students (elementary school II) in 11 classes of four public schools in the city of São Paulo.

Results: The level of agreement was substantial (Kappa 0.60–0.79) or almost perfect (Kappa > 0.8) for almost all questions about the use of marijuana, alcohol, cigarettes, cocaine, crack, and binge drinking. The model fit indices, for almost all secondary outcomes, indicated that the modls underlying each scale, constituted by observed and latent variables, had a good fit adjustument. The focus groups and field cards provided high-quality information that helped the researchers identify the main difficulties in applying and understanding the questions.

Conclusion: The questionnaire showed high factorial validity, reliability and understanding by adolescents. After the necessary changes, identified in this study, the questionnaire will be suitable to evaluate the results of the #Tamojunto2.0 program in a randomized controlled trial.
“Want to Learn” and “Can Learn”: Influence of Academic Passion on College Students' Academic Engagement
Authors: Zhao Hui , Liu Xiaoxian , Qi Chunhui
Published: June 2021

Although research exists on the relationship between passion and engagement among employees, the mechanisms of academic passion on academic engagement among students needs to be elucidated. Guided by the broaden-and-build and situated cognition theories, we explored the positive effect of academic passion on academic engagement, the mediating effect of academic self-efficacy, and the role of teacher developmental feedback as a moderator in the relationship between academic passion and academic engagement. Based on a sample of 1,029 college students from universities in the Henan Province of China, the results showed that academic passion was positively related to academic engagement, academic self-efficacy partially mediated the relationship between academic passion and academic engagement, and teacher developmental feedback effectively moderated the relationship between academic passion and academic engagement. These findings explained the mechanism underlying the relationship between academic passion and academic engagement. Moreover, the findings highlighted important factors that promote college students' academic engagement.
Common Venues in Romantic Relationships of Adults With Symptoms of Autism and Attention Deficit/Hyperactivity Disorder
Authors: Soares Lorrayne Stephane , Alves Ana Luiza Costa , Costa Danielle de Souza , Malloy-Diniz Leandro Fernandes , Paula Jonas Jardim de , Romano-Silva Marco Aurélio , Miranda Débora Marques de
Published: June 2021

Introduction: Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) figures among the most common neurodevelopmental disorders. Despite having opposite stereotypes, both ADHD and ASD compromise, though in different ways, skills such as social interactions, communication skills, and social thinking, which may underlie difficulties in romantic relationships.

Methods: We evaluated 306 adults about their romantic relationships and the intensity of their love. Participants were from one of four groups:, individuals with ASD-only traits, a group with symptoms of ADHD-only, participants with neither ADHD nor ASD symptoms (control) or from a fourth group of individuals with both ADHD and ASD traits.

Results: The ASD traits group had fewer married people and more people who have never been married, while the rate of divorce was higher in the ADHD traits group. Regarding the intensity of love, the mean scores of the ADHD and the ADHD+ASD traits groups were higher in the Passionate Love Scale than the mean score of the control group. Passionate love in the ASD group was no different from the other groups. Small positive correlations were found between passionate love and ADHD and ASD behavioral problems.

Conclusion: Marital status was distinct depending on symptoms of a neurodevelopmental disorder in adulthood. Also, ADHD and ASD symptoms were associated with greater passionate love. Therefore, ADHD and ASD behavioral dimensions may impact long-term and short-term experiences of a person's relationship with a significant other in distinct ways. Understanding how people with neurodevelopmental disorders experience love might help us to better clarify the mechanisms associated with their relationship patterns.
A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis
Authors: Ghafouri-Fard Soudeh , Eghtedarian Reyhane , Taheri Mohammad , Beatrix Brühl Annette , Sadeghi-Bahmani Dena , Brand Serge
Published: June 2021

Schizophrenia is a destructive neuropsychiatric disease with a median prevalence of 4.0 per 1,000 during the whole life. Genome-wide association studies have shown the role of copy number variants (generally deletions) and certain alleles of common single nucleotide polymorphisms in the pathogenesis of schizophrenia. This disorder predominantly follows the polygenic inheritance model. Schizophrenia has also been linked with various alterations in the transcript and protein content of the brain tissue. Recent studies indicate that alterations in non-coding RNAs (ncRNAs) signature underlie a proportion of this dysregulation. High throughput microarray investigations have demonstrated momentous alterations in the expression of long non-coding RNAs (lncRNA) and microRNAs (miRNAs) in the circulation or post-mortem brain tissues of patients with schizophrenia compared with control samples. While Gomafu, PINT, GAS5, TCONS_l2_00021339, IFNG-AS1, FAS-AS1, PVT1, and TUG1 are among down-regulated lncRNAs in schizophrenia, MEG3, THRIL, HOXA-AS2, Linc-ROR, SPRY4-IT1, UCA1, and MALAT1 have been up-regulated in these patients. Moreover, several miRNAs, such as miR-30e, miR-130b, hsa-miR-130b, miR-193a-3p, hsa-miR-193a-3p, hsa-miR-181b, hsa-miR-34a, hsa-miR-346, and hsa-miR-7 have been shown to be dysregulated in blood or brain samples of patients with schizophrenia. Dysregulation of these transcripts in schizophrenia not only provides insight into the pathogenic processes of this disorder, it also suggests these transcripts could serve as diagnostic markers for schizophrenia. In the present paper, we explore the changes in the expression of miRNAs and lncRNAs in patients with schizophrenia.
A Bird's-Eye View of Exercise Intervention in Treating Depression Among Teenagers in the Last 20 Years: A Bibliometric Study and Visualization Analysis
Authors: You Yanwei , Wang Dizhi , Wang Yuning , Li Zhipeng , Ma Xindong
Published: June 2021

Background: Exercise is medicine. Multiple studies on the effects and mechanisms of exercise in treating depression among teenagers and adolescents have been widely reported. However, literature involving scientometric analysis of this topic is sparse. Here, we endeavored to conduct a bibliometric study and visualization analysis to give a bird's-eye view of publications between 2000 and 2020 on exercise therapy treating depression.

Methods: Relevant original publications were obtained from the Science Citation Index Expanded in the Web of Science Core Collection (WoSCC) database between 2000 and 2020. CiteSpace (5.7.R 5) and VOSviewer (1.6.16) software were used to perform bibliometric analysis of countries, institutions, categories, journals, authors, references, and keywords involved in this topic.

Results: A total number of 975 articles on this field were retrieved from the WoSCC database and we identified an overall increase in the amount of publications over the past two decades, with the United States and Harvard University leading the field. Most related publications were published in the journals with a focus on sport, medicine, rehabilitation, psychology, and health, as represented by the dual-map overlay. A series of authors and co-cited authors were identified as main contributors in the exercise-depression-teenager domain. Three major clusters were explored based on the reference co-citation analysis: “exercise,” “suicide,” and “concussion”.

Conclusions: Current concerns and hotspots of exercise intervention in depression treatments were summarized by “individual level,” “social level,” “role of exercise,” and “research quality.” We considered that the following four directions were potential future perspectives: “research on the effect of specific exercise intervention,” “research on the essence of exercise and sports,” “research on the combination mode of ‘exercise + X',” and “research on the micro and molecular level,” which should receive more attention.
Ketamine and Attentional Bias Toward Emotional Faces: Dynamic Causal Modeling of Magnetoencephalographic Connectivity in Treatment-Resistant Depression
Authors: Gilbert Jessica R. , Galiano Christina S. , Nugent Allison C. , Zarate Carlos A.
Published: June 2021

The glutamatergic modulator ketamine rapidly reduces depressive symptoms in individuals with treatment-resistant major depressive disorder (TRD) and bipolar disorder. While its underlying mechanism of antidepressant action is not fully understood, modulating glutamatergically-mediated connectivity appears to be a critical component moderating antidepressant response. This double-blind, crossover, placebo-controlled study analyzed data from 19 drug-free individuals with TRD and 15 healthy volunteers who received a single intravenous infusion of ketamine hydrochloride (0.5 mg/kg) as well as an intravenous infusion of saline placebo. Magnetoencephalographic recordings were collected prior to the first infusion and 6–9 h after both drug and placebo infusions. During scanning, participants completed an attentional dot probe task that included emotional faces. Antidepressant response was measured across time points using the Montgomery-Asberg Depression Rating Scale (MADRS). Dynamic causal modeling (DCM) was used to measure changes in parameter estimates of connectivity via a biophysical model that included realistic local neuronal architecture and receptor channel signaling, modeling connectivity between the early visual cortex, fusiform cortex, amygdala, and inferior frontal gyrus. Clinically, ketamine administration significantly reduced depressive symptoms in TRD participants. Within the model, ketamine administration led to faster gamma aminobutyric acid (GABA) and N-methyl-D-aspartate (NMDA) transmission in the early visual cortex, faster NMDA transmission in the fusiform cortex, and slower NMDA transmission in the amygdala. Ketamine administration also led to direct and indirect changes in local inhibition in the early visual cortex and inferior frontal gyrus and to indirect increases in cortical excitability within the amygdala. Finally, reductions in depressive symptoms in TRD participants post-ketamine were associated with faster α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) transmission and increases in gain control of spiny stellate cells in the early visual cortex. These findings provide additional support for the GABA and NMDA inhibition and disinhibition hypotheses of depression and support the role of AMPA throughput in ketamine's antidepressant effects.

Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT00088699?term=NCT00088699&draw=2&rank=1, identifier NCT00088699.
Developing a mHealth Routine Outcome Monitoring and Feedback App (“SMART Track”) to Support Self-Management of Addictive Behaviours
Authors: Beck Alison K. , Kelly Peter J. , Deane Frank P. , Baker Amanda L. , Hides Leanne , Manning Victoria , Shakeshaft Anthony , Neale Joanne , Kelly John F. , Gray Rebecca M. , Argent Angela , McGlaughlin Ryan , Chao Ryan , Martini Marcos
Published: June 2021

Background: Routine outcome monitoring (ROM) has been implemented across a range of addiction treatment services, settings and organisations. Mutual support groups are a notable exception. Innovative solutions are needed. SMART Track is a purpose built smartphone app designed to capture ROM data and provide tailored feedback to adults attending Australian SMART Recovery groups for addictive behaviour(s).

Objective: Details regarding the formative stage of app development is essential, but often neglected. Improved consideration of the end-user is vital for curtailing app attrition and enhancing engagement. This paper provides a pragmatic example of how principles embedded in published frameworks can be operationalised to address these priorities during the design and development of the SMART Track app.

Methods: Three published frameworks for creating digital health technologies (“Person-Based Approach,” “BIT” Model and IDEAS framework) were integrated and applied across two stages of research to inform the development, design and content of SMART Track. These frameworks were chosen to ensure that SMART Track was informed by the needs and preferences of the end-user (“Person-Based”); best practise recommendations for mHealth development (“BIT” Model) and a collaborative, iterative development process between the multi-disciplinary research team, app developers and end-users (IDEAS framework).

Results: Stage one of the research process generated in-depth knowledge to inform app development, including a comprehensive set of aims (clinical, research/organisation, and usage); clear articulation of the target behaviour (self-monitoring of recovery related behaviours and experiences); relevant theory (self-determination and social control); appropriate behavioural strategies (e.g., behaviour change taxonomy and process motivators) and key factors that may influence engagement (e.g., transparency, relevance and trust). These findings were synthesised into guiding principles that were applied during stage two in an iterative approach to app design, content and development.

Conclusions: This paper contributes new knowledge on important person-centred and theoretical considerations that underpin a novel ROM and feedback app for people with addictive behaviour(s). Although person-centred design and best-practise recommendations were employed, further research is needed to determine whether this leads to improved usage outcomes.

Clinical Trial Registration: Pilot Trial: http://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377336.
The Role of Parvalbumin Interneurons in Neurotransmitter Balance and Neurological Disease
Authors: Nahar Lailun , Delacroix Blake M. , Nam Hyung W.
Published: June 2021

While great progress has been made in the understanding of neurological illnesses, the pathologies, and etiologies that give rise to these diseases still remain an enigma, thus, also making treatments for them more challenging. For effective and individualized treatment, it is beneficial to identify the underlying mechanisms that govern the associated cognitive and behavioral processes that go awry in neurological disorders. Parvalbumin fast-spiking interneurons (Pv-FSI) are GABAergic cells that are only a small fraction of the brain's neuronal network, but manifest unique cellular and molecular properties that drastically influence the downstream effects on signaling and ultimately change cognitive behaviors. Proper brain functioning relies heavily on neuronal communication which Pv-FSI regulates, excitatory-inhibitory balances and GABAergic disinhibition between circuitries. This review highlights the depth of Pv-FSI involvement in the cortex, hippocampus, and striatum, as it pertains to expression, neurotransmission, role in neurological disorders, and dysfunction, as well as cognitive behavior and reward-seeking. Recent research has indicated that Pv-FSI play pivotal roles in the molecular pathophysiology and cognitive-behavioral deficits that are core features of many psychiatric disorders, such as schizophrenia, autism spectrum disorders, Alzheimer's disease, and drug addiction. This suggests that Pv-FSI could be viable targets for treatment of these disorders and thus calls for further examination of the undeniable impact Pv-FSI have on the brain and cognitive behavior.
Housing and Care for Older Women in Australia
Authors: Byles Julie E. , Princehorn Emily M. , Forder Peta M. , Rahman Md Mijanur
Published: June 2021

Background: Housing is essential for healthy ageing, being a source of shelter, purpose, and identity. As people age, and with diminishing physical and mental capacity, they become increasingly dependent on external supports from others and from their environment. In this paper we look at changes in housing across later life, with a focus on the relationship between housing and women's care needs.

Methods: Data from 12,432 women in the 1921–26 cohort of the Australian Longitudinal Study on Women's Health were used to examine the interaction between housing and aged care service use across later life.

Results: We found that there were no differences in access to home and community care according to housing type, but women living in an apartment and those in a retirement village/hostel were more likely to have an aged care assessment and had a faster rate of admission to institutional residential aged care than women living in a house. The odds of having an aged care assessment were also higher if women were older at baseline, required help with daily activities, reported a fall, were admitted to hospital in the last 12 months, had been diagnosed or treated for a stroke in the last 3 years, or had multiple comorbidities. On average, women received few services in the 24 months prior to admission to institutional residential aged care, indicating a potential need to improve the reach of these services.

Discussion: We find that coincident with changes in functional capacities and abilities, women make changes to their housing, sometimes moving from a house to an apartment, or to a village. For some, increasing needs in later life are associated with the need to move from the community into institutional residential aged care. However, before moving into care, many women will use community services and these may in turn delay the need to leave their homes and move to an institutional setting. We identify a need to increase the use of community services to delay the admission to institutional residential aged care.
Out-of-Hospital Cervical Ripening With a Synthetic Hygroscopic Cervical Dilator May Reduce Hospital Costs and Cesarean Sections in the United States—A Cost-Consequence Analysis
Authors: Saunders Sita J. , Saunders Rhodri , Wong Tess , Saad Antonio F.
Published: June 2021

Objective: Out-of-hospital (outpatient) cervical ripening prior to induction of labor (IOL) is discussed for its potential to decrease the burden on hospital resources. We assessed the cost and clinical outcomes of adopting an outpatient strategy with a synthetic hygroscopic cervical dilator, which is indicated for use in preinduction cervical ripening.

Methods: We developed a cost-consequence model from the hospital perspective with a time period from IOL to post-delivery discharge. A hypothetical cohort of women to undergo IOL at term with an unfavorable cervix (all risk levels) were assessed. As the standard of care (referred to as IP-only) all women were ripened as inpatients using the vaginal PGE2 insert or the single-balloon catheter. In the comparison (OP-select), 50.9% of low-risk women (41.4% of the study population) received outpatient cervical ripening using a synthetic hygroscopic cervical dilator and the remaining women were ripened as inpatients as in the standard of care. Model inputs were sourced from a structured literature review of peer-reviewed articles in PubMed. Testing of 2,000 feasible scenarios (probabilistic multivariate sensitivity analysis) ascertained the robustness of results. Outcomes are reported as the average over all women assessed, comparing OP-select to IP-only.

Results: Implementing OP-select resulted in hospital savings of US$689 per delivery, with women spending 1.48 h less time in the labor and delivery unit and 0.91 h less in the postpartum recovery unit. The cesarean-section rate was decreased by 3.78 percentage points (23.28% decreased to 19.50%). In sensitivity testing, hospital costs and cesarean-section rate were reduced in 91% of all instances.

Conclusion: Our model analysis projects that outpatient cervical ripening has the potential to reduce hospital costs, hospital stay, and the cesarean section rate. It may potentially allow for better infection-prevention control during the ongoing COVID-19 pandemic and to free up resources such that more women might be offered elective IOL at 39 weeks.
Does Industrial Air Pollution Increase Health Care Expenditure? Evidence From China
Authors: Shen Jin-Sheng , Wang Qun , Shen Han-Pu
Published: June 2021

This paper discusses the impact of air pollution on medical expenditure in eastern, central, and western China by applying the fixed-effect model, random-effect model, and panel threshold regression model. According to theoretical and empirical analyses, there are different relationships between the two indexes in different regions of China. For eastern and central regions, it is obvious that the more serious the air pollution is, the more medical expenses there are. However, there is a non-linear single threshold effect between air pollution and health care expenditure in the western region. When air pollution is lower than this value, there is a negative correlation between them. Conversely, the health care expenditure increases with the aggravation of air pollution, but the added value is not enough to make up for the health problems caused by air pollution. The empirical results are basically consistent with the theoretical analysis, which can provide enlightenment for the government to consider the role of air pollution in medical expenditure. Policymakers should arrange the medical budget reasonably, according to its situation, to make up for the loss caused by air pollution.
Does the Economic Growth Improve Public Health? A Cross-Regional Heterogeneous Study in China
Authors: Niu Xiao-Tong , Yang You-Cai , Wang Yu-Cong
Published: June 2021

On public health, the effect of economic growth in China is analyzed in this paper by using the panel threshold regression model. The empirical study from 2000 to 2017 shows that China's economic growth has a significant threshold effect on public health. After the threshold is exceeded, public health will be improved dramatically. The threshold effect is heterogeneous at the regional level. The eastern region has no threshold, and both central and western regions have a single significant threshold. However, the threshold value and threshold effect in the central and western regions are also different. The heterogeneity is caused by the different levels of regional economic development. Therefore, based on public health utility maximization, the government should make different health policies according to the characteristics of regional development.
A Holistic Approach to Human-Supervised Humanoid Robot Operations in Extreme Environments
Authors: Wonsick Murphy , Long Philip , Önol Aykut Özgün , Wang Maozhen , Padır Taşkın
Published: June 2021

Nuclear energy will play a critical role in meeting clean energy targets worldwide. However, nuclear environments are dangerous for humans to operate in due to the presence of highly radioactive materials. Robots can help address this issue by allowing remote access to nuclear and other highly hazardous facilities under human supervision to perform inspection and maintenance tasks during normal operations, help with clean-up missions, and aid in decommissioning. This paper presents our research to help realize humanoid robots in supervisory roles in nuclear environments. Our research focuses on National Aeronautics and Space Administration (NASA’s) humanoid robot, Valkyrie, in the areas of constrained manipulation and motion planning, increasing stability using support contact, dynamic non-prehensile manipulation, locomotion on deformable terrains, and human-in-the-loop control interfaces.
A Pediatric Knee Exoskeleton With Real-Time Adaptive Control for Overground Walking in Ambulatory Individuals With Cerebral Palsy
Authors: Chen Ji , Hochstein Jon , Kim Christina , Tucker Luke , Hammel Lauren E. , Damiano Diane L. , Bulea Thomas C.
Published: June 2021

Gait training via a wearable device in children with cerebral palsy (CP) offers the potential to increase therapy dosage and intensity compared to current approaches. Here, we report the design and characterization of a pediatric knee exoskeleton (P.REX) with a microcontroller based multi-layered closed loop control system to provide individualized control capability. Exoskeleton performance was evaluated through benchtop and human subject testing. Step response tests show the averaged 90% rise was 26 ± 0.2 ms for 5 Nm, 22 ± 0.2 ms for 10 Nm, 32 ± 0.4 ms for 15 Nm. Torque bandwidth of P.REX was 12 Hz and output impedance was less than 1.8 Nm with control on (Zero mode). Three different control strategies can be deployed to apply assistance to knee extension: state-based assistance, impedance-based trajectory tracking, and real-time adaptive control. One participant with typical development (TD) and one participant with crouch gait from CP were recruited to evaluate P.REX in overground walking tests. Data from the participant with TD were used to validate control system performance. Kinematic and kinetic data were collected by motion capture and compared to exoskeleton on-board sensors to evaluate control system performance with results demonstrating that the control system functioned as intended. The data from the participant with CP are part of a larger ongoing study. Results for this participant compare walking with P.REX in two control modes: a state-based approach that provided constant knee extension assistance during early stance, mid-stance and late swing (Est+Mst+Lsw mode) and an Adaptive mode providing knee extension assistance proportional to estimated knee moment during stance. Both were well tolerated and significantly improved knee extension compared to walking without extension assistance (Zero mode). There was less reduction in gait speed during use of the adaptive controller, suggesting that it may be more intuitive than state-based constant assistance for this individual. Future work will investigate the effects of exoskeleton assistance during overground gait training in children with neurological disorders and will aim to identify the optimal individualized control strategy for exoskeleton prescription.
Co-producing a Community University Knowledge Strategy
Authors: Bell Sarah , Lee Richard , Fitzpatrick Daniel , Mahtani Sona
Published: June 2021

This community case study describes the process of developing a strategy for community-university engagement, as an example of co-production, and presents the strategy and early outcomes of the work. Based in London, the strategy and the process of co-production are of international relevance in supporting more productive relationships between universities and their cities, as a foundation for repurposing universities for sustainable human progress. The case study is presented in the context of literature related to community engagement with universities and co-production, an area of growing concern as universities seek to strengthen relationships and contribution to sustainable human progress in their home cities. London is one of the world's great university cities, with more than 40 higher education institutions contributing ground-breaking research and educating students from across the globe. London is also home to vibrant local communities, with a strong tradition of grassroots action, community organization and citizen participation. Community groups and universities have a strong history of working together, often without formal recognition or resources. The Community university Knowledge Strategy for London, known as Collaborate!, was a collaboration between universities and grassroots community groups in London, co-convened by Just Space and University College London (UCL). A series of workshops, guided by two steering committees of community and university members, explored principles for working together, cultural and institutional barriers, decolonization, industrial strategies, community spaces and case studies of good practice. The final conference outlined the basis for a London-wide strategy to enable better engagement between universities and grassroots community groups. The strategy addresses core principles, curriculum, evaluation and evidence, resources, relationship building, governance and structures to support collaboration. Co-production ensured high levels of trust between participants and commitment to the outcomes. Implementation of the strategy actions requires ongoing resources to support intermediary structures to overcome misalignment between universities as large, hierarchical institutions and community groups as dynamic, informal, social organizations.
Necropolitics and Diffuse Violence: Critical Reflections on Social Discourses About the LGBT Body
Authors: Ribeiro Cristine Jaques , Moraes Camila de Freitas , Silva de Oliveira Lívio
Published: June 2021

This article aims to discuss the state’s function and the speeches about the LGBT body from the theoretical concept of necropolitics, defended by Achille Mbembe, which apprehends that this is a sovereign state that subdues, oppresses, and acts for the management of politics of death and applies them on bodies and populations, determining who is subject to live or die. The concept of necropolitics will be enunciated with diffuse violence as a systemic concept that demarcates social relations, and forms of sociability in contemporaneity as defensive behaviors that can legitimize human rights violations. Diffuse violence recognizes the increasing criminal rates, especially homicides and patrimonial offenses, as the main factor in producing diffuse fear, connoting a generalization of the feeling of insecurity. However, this dynamic also points out which types and social groups are most vulnerable to violence. Based on these theoretical and methodological contributions, we will seek to understand how social discourses and their implications are transversal to the LGBT body and how they manifest through oppression.
Optimizing Nitrogen Fixation and Recycling for Food Production in Regenerative Life Support Systems
Authors: Langenfeld Noah J. , Kusuma Paul , Wallentine Tyler , Criddle Craig S. , Seefeldt Lance C. , Bugbee Bruce
Published: June 2021

Nitrogen (N) recycling is essential for efficient food production in regenerative life support systems. Crew members with a high workload need 90–100 g of protein per person per day, which is about 14 g of N, or 1 mole of N, per person per day. Most of this N is excreted through urine with 85% as urea. Plants take up N predominantly as nitrate and ammonium, but direct uptake as urea is possible in small amounts. Efficient N recycling requires maintenance of pH of waste streams below about 7 to minimize the volatilization of N to ammonia. In aerobic reactors, continuous aerobic conditions are needed to minimize production and volatilization of nitrous oxide. N is not well recycled on Earth. The energy intensive Haber–Bosh process supplies most of the N for crop production in terrestrial agriculture. Bacterial fixation of dinitrogen to ammonium is also energy intensive. Recycling of N from plant and human waste streams is necessary to minimize the need for N fixation. Here we review approaches and potential for N fixation and recycling in regenerative life support systems. Initial estimates indicate that nearly all the N from human and plant waste streams can be recovered in forms usable for plants.
Genome Wide Prediction, Mapping and Development of Genomic Resources of Mastitis Associated Genes in Water Buffalo
Authors: Jaiswal Sarika , Jagannadham Jaisri , Kumari Juli , Iquebal Mir Asif , Gurjar Anoop Kishor Singh , Nayan Varij , Angadi Ulavappa B. , Kumar Sunil , Kumar Rakesh , Datta Tirtha Kumar , Rai Anil , Kumar Dinesh
Published: June 2021

Water buffalo (Bubalus bubalis) are an important animal resource that contributes milk, meat, leather, dairy products, and power for plowing and transport. However, mastitis, a bacterial disease affecting milk production and reproduction efficiency, is most prevalent in populations having intensive selection for higher milk yield, especially where the inbreeding level is also high. Climate change and poor hygiene management practices further complicate the issue. The management of this disease faces major challenges, like antibiotic resistance, maximum residue level, horizontal gene transfer, and limited success in resistance breeding. Bovine mastitis genome wide association studies have had limited success due to breed differences, sample sizes, and minor allele frequency, lowering the power to detect the diseases associated with SNPs. In this work, we focused on the application of targeted gene panels (TGPs) in screening for candidate gene association analysis, and how this approach overcomes the limitation of genome wide association studies. This work will facilitate the targeted sequencing of buffalo genomic regions with high depth coverage required to mine the extremely rare variants potentially associated with buffalo mastitis. Although the whole genome assembly of water buffalo is available, neither mastitis genes are predicted nor TGP in the form of web-genomic resources are available for future variant mining and association studies. Out of the 129 mastitis associated genes of cattle, 101 were completely mapped on the buffalo genome to make TGP. This further helped in identifying rare variants in water buffalo. Eighty-five genes were validated in the buffalo gene expression atlas, with the RNA-Seq data of 50 tissues. The functions of 97 genes were predicted, revealing 225 pathways. The mastitis proteins were used for protein-protein interaction network analysis to obtain additional cross-talking proteins. A total of 1,306 SNPs and 152 indels were identified from 101 genes. Water Buffalo-MSTdb was developed with3-tier architectureto retrieve mastitis associated genes having genomic coordinates with chromosomal details for TGP sequencing for mining of minor alleles for further association studies. Lastly, a web-genomic resource was made available to mine variants of targeted gene panels in buffalo for mastitis resistance breeding in an endeavor to ensure improved productivity and the reproductive efficiency of water buffalo.
Integrated Building Energy Simulation–Life Cycle Assessment (BES–LCA) Approach for Environmental Assessment of Agricultural Building: A Review and Application to Greenhouse Heating Systems
Authors: Decano-Valentin Cristina , Lee In-Bok , Yeo Uk-Hyeon , Lee Sang-Yeon , Kim Jun-Gyu , Park Se-Jun , Choi Young-Bae , Cho Jeong-Hwa , Jeong Hyo-Hyeog
Published: June 2021

A substantial reduction in the environmental impacts related to the construction and operation of agricultural buildings is needed to adapt to the continuing development of agriculture. The life cycle assessment (LCA) is a methodology used to quantify the environmental impact of different processes involved in the production and therefore has been increasingly applied to assess the environmental burden. However, most LCA-related research studies have focused on the overall environmental impact of the entire system without considering the energy load of the agricultural buildings. By integrating the LCA tool with other design tools such as the building energy simulation (BES), the identification of environmental hotspots and the mitigation options become possible during the design process. Thus, the objective of the paper was to identify the current integration approaches used to combine BES and LCA results to assess the environmental impact of different heating systems such as absorption heat pump (AHP) using energy from thermal effluent, electricity-powered heat pump and kerosene-powered boilers used in a conventional multi-span Korean greenhouse. The assessment result revealed that the environmental impact caused using a kerosene-powered boiler is largest in terms of the acidification potential (AP), global warming potential (GWP) and Eutrophication Potential (EP) of 1.15 × 100 kg SO2-eq, 1.13 × 102 kg CO2-eq and 1.62 × 10−1 kg PO4-eq, respectively. Detailed analysis of the result showed that the main contributor for greenhouse gas emission was caused by the type, amount and source of energy used to heat the greenhouse, which contributed to a maximum of 86.59% for case 1, 96.69% for case 2 and a maximum of 96.47% for case 3, depending on the type of greenhouse gas being considered.
Genomic Prediction in Local Breeds: The Rendena Cattle as a Case Study
Authors: Mancin Enrico , Tuliozi Beniamino , Sartori Cristina , Guzzo Nadia , Mantovani Roberto
Published: June 2021

The maintenance of local cattle breeds is key to selecting for efficient food production, landscape protection, and conservation of biodiversity and local cultural heritage. Rendena is an indigenous cattle breed from the alpine North-East of Italy, selected for dual purpose, but with lesser emphasis given to beef traits. In this situation, increasing accuracy for beef traits could prevent detrimental effects due to the antagonism with milk production. Our study assessed the impact of genomic information on estimated breeding values (EBVs) in Rendena performance-tested bulls. Traits considered were average daily gain, in vivo EUROP score, and in vivo estimate of dressing percentage. The final dataset contained 1691 individuals with phenotypes and 8372 animals in pedigree, 1743 of which were genotyped. Using the cross-validation method, three models were compared: (i) Pedigree-BLUP (PBLUP); (ii) single-step GBLUP (ssGBLUP), and (iii) weighted single-step GBLUP (WssGBLUP). Models including genomic information presented higher accuracy, especially WssGBLUP. However, the model with the best overall properties was the ssGBLUP, showing higher accuracy than PBLUP and optimal values of bias and dispersion parameters. Our study demonstrated that integrating phenotypes for beef traits with genomic data can be helpful to estimate EBVs, even in a small local breed.
Application of the Ridden Horse Pain Ethogram to Horses Competing at the Hickstead-Rotterdam Grand Prix Challenge and the British Dressage Grand Prix National Championship 2020 and Comparison with World Cup Grand Prix Competitions
Authors: Dyson Sue , Pollard Danica
Published: June 2021

The Ridden Horse Pain Ethogram (RHpE) comprising 24 behaviours was developed to facilitate the identification of musculoskeletal discomfort, with scores of ≥8/24 indicating the presence of pain. The median RHpE score for 147 competitors at World Cup Grand Prix events from 2018 to 2020 was three (interquartile range [IQR] 1–4; range 0–7). The aim of the current study was to apply the RHpE to 38 competitors at the Hickstead-Rotterdam Grand Prix Challenge and 26 competitors at the British Dressage Grand Prix National Championship in 2020. The median RHpE scores were four (IQR 3–6; range 0–8) and six (IQR 4–7; range 1–9), respectively, which were both higher (p = 0.0011 and p = 0.0000) than the World Cup competitors’ scores. Ears back ≥ 5 s (p = 0.005), intense stare ≥ 5 s (p = 0.000), repeated tail swishing (p = 0.000), hindlimb toe drag (p = 0.000), repeated tongue-out (p = 0.003) and crooked tail-carriage (p = 0.000) occurred more frequently. These were associated with a higher frequency of lameness, abnormalities of canter, and errors in rein-back, passage and piaffe, canter flying-changes and canter pirouettes compared with World Cup competitors. There was a moderate negative correlation between the dressage judges’ scores and the RHpE scores (Spearman’s rho −0.66, p = 0.0002) at the British Championship. Performance and welfare may be improved by recognition and appropriate treatment of underlying problems.
Effects of Season, Plumage Colour, and Transport Distance on Body Weight Loss, Dead-on-Arrival, and Reject Rate in Commercial End-of-Lay Hens
Authors: Çavuşoğlu Enver , Petek Metin
Published: June 2021

Transport conditions of end-of-lay hens are important for their welfare. This study investigated the effects of season, plumage colour, and transportation distance on the welfare of end-of-lay hens. Retrospective data from 31,667,274 end-of-lay hens transported to a poultry slaughterhouse in Turkey were analysed. The mean body weight loss, dead-on-arrival (DOA) rate, and reject rate were 3.723%, 1.397%, and 0.616%, respectively. The effects of season, plumage colour, and transport distance on the evaluated parameters were all statistically significant (p < 0.001). The highest body weight loss was found in winter, while the lowest body weight loss was found in autumn. The average DOA rate was highest in spring and lowest in autumn. The highest average reject rate was found in spring (0.630%). Body weight loss, DOA rates, and reject rates were also significantly different among white and brown hens (p < 0.001; p < 0.001; p = 0.016, respectively). The highest body weight loss and reject rates were found in white plumage hens, while the highest DOA rate was found in brown plumage hens. The body weight loss and DOA rate were positively correlated with transportation distance (p < 0.001). The results of this study indicate that more preventive measures should be taken during the transport of end-of-lay hens, especially in cold seasons such as winter, and over longer transport distances, in regard to the welfare of these animals. Additionally, the transport of these animals should be lessened to a certain distance.
Impact of Dietary Crude Protein Level on Hepatic Lipid Metabolism in Weaned Female Piglets
Authors: Liu Ning , Ji Yun , Yang Ying , Jia Hai , Si Xuemeng , Jiang Da , Zhang Yunchang , Dai Zhaolai , Wu Zhenlong
Published: June 2021

Amino acids serve not only as building blocks for proteins, but also as substrates for the synthesis of low-molecular-weight substances involved in hepatic lipid metabolism. In the present study, eighteen weaned female piglets at 35 days of age were fed a corn- and soybean meal-based diet containing 20%, 17%, or 14% crude protein (CP), respectively. We found that 17% or 20% CP administration reduced the triglyceride and cholesterol concentrations, while enhanced high-density lipoprotein cholesterol (HDL-C) concentration in serum. Western blot analysis showed that piglets in the 20% CP group had higher protein abundance of hormone-sensitive triglyceride lipase (HSL) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), as compared with other groups. Moreover, the mRNA expression of sterol regulatory element binding transcription factor 1 (SREBPF1), fatty acid synthase (FASN), and stearoyl-CoA desaturase (SCD) were lower in the 17% or 20% CP group, compared with those of the piglets administered with 14% CP. Of note, the mRNA level of acetyl-CoA carboxylase alpha (ACACα) was lower in the 17% CP group, compared with other groups. Additionally, the mRNA level of lipoprotein lipase (LPL), peroxisome proliferator-activated receptor alpha α (PPARα), glucose-6-phosphatase catalytic subunit (G6PC), and phosphoenolpyruvate carboxykinase 1 (PKC1) in the liver of piglets in the 20% CP group were higher than those of the 14% CP group. Collectively, our results demonstrated that dietary CP could regulate hepatic lipid metabolism through altering hepatic lipid lipogenesis, lipolysis, oxidation, and gluconeogenesis.
Loaded Plyometrics and Short Sprints with Change-of-Direction Training Enhance Jumping, Sprinting, Agility, and Balance Performance of Male Soccer Players
Authors: Aloui Ghaith , Hermassi Souhail , Hayes Lawrence D. , Bouhafs El Ghali , Chelly Mohamed Souhaiel , Schwesig René
Published: June 2021

This project investigated effects of 8 weeks of biweekly loaded combined plyometric and short sprint with change-of-direction training an in-season regimen of young soccer players. An experimental (n = 17, age: 16.5 ± 0.5 years, body mass: 64.5 ± 5.2 kg, height: 1.73 ± 0.07 m,) and control group (n = 17, age: 16.7 ± 0.5 years, body mass: 65.6 ± 4.8 kg, height: 1.74 ± 0.07 m) were tested pre- and post-intervention for squat-jump (SJ), countermovement-jump (CMJ), and five-jump test (5JT), 10 m and 30 m sprint performance, change-of-direction ability, and dynamic balance performance. The experimental group (EG) outperformed the control group (CG) over 8 weeks in jumping (p < 0.001; d = 0.98–1.17), 10 m sprinting (p < 0.001; d = 0.94), change-of-direction ability (p < 0.001; d = 1.24), and dynamic balance performance (p < 0.001; d = 0.53–0.74). We conclude that adding biweekly loaded plyometric with short sprints and change-of-direction training to habitual training improves athleticism of young soccer players. Therefore, loaded plyometric with short sprints and change-of-direction training should be implemented as a part of research-informed soccer training.
Latest Advances on Synthesis, Purification, and Characterization of Peptides and Their Applications
Authors: El-Faham Ayman , de la Torre Beatriz G. , Albericio Fernando
Published: June 2021

Peptides have a broad number of applications: from biochemical tools to diagnostic kits; from nanotechnology to new materials; and from vaccines to drugs [...]