bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Karakteristik Off Street Parking di Solo Paragon Lifestyle Mall
Authors: Magfirona Alfia , Farchani Muhamad Abas , Mulyono Gotot Slamet , Hidayati Nurul
Published: August 2024

The rapid development of the trade sector in Surakarta City has caused various problems. One of them is the limited parking facilities at Solo Paragon Lifestyle Mall due to the density of visitors. This study aims to analyze parking capacity, parking accumulation, parking volume, parking duration, turnover rate, parking index, and problem-handling strategies. Data was obtained from a survey recording the number, time, and license plate number of vehicles in and out on weekdays and weekends. The analysis results show. The parking capacity of two-wheeled vehicles is 711 SRP and four-wheeled 490 SRP. Weekends show an increase compared to weekdays. The highest accumulation of 820 two-wheeled vehicles in the 14:30-14:45 WIB period has exceeded capacity. The highest vehicle volume reached 2423 vehicles; the highest parking duration was 104.20 minutes for four-wheeled vehicles. Turnover was 3.63 (vehicles/day/space). The second highest vehicle index is 115% for two-wheeled vehicles. The handling strategies offered include increasing the standard or limitation of the maximum amount of parking, better parking supervision, and adding parking exits to unravel the queue of visitor vehicles leaving the mall.
ABSTRAK
Perkembangan sektor perdagangan di Kota Surakarta yang semakin pesat menimbulkan berbagai permasalahan. Salah satunya yaitu keterbatasan sarana parkir di Solo Paragon Lifestyle Mall dikarenakan padatnya pengunjung. Penelitian ini bertujuan untuk menganalisis kapasitas parkir, akumulasi parkir, volume parkir, durasi parkir, tingkat turn over, indeks parkir serta strategi penanganan masalah. Data diperoleh dari survei pencatatan jumlah, waktu dan nomor pelat kendaraan keluar masuk di hari kerja dan akhir pekan. Hasil analisis menunjukkan. Kapasitas parkir kendaraan roda dua sebesar 711 SRP dan roda empat 490 SRP. Di akhir pekan menunjukkan peningkatan dibandingkan hari kerja. Akumulasi tertinggi sebesar 820 kendaraan roda dua yang berlangsung pada periode waktu 14:30-14:45 WIB telah melebihi kapasitas. Volume kendaraan tertinggi mencapai 2423 kendaraan dan durasi parkir tertinggi yaitu 104,20 menit untuk jenis kendaraan roda empat. Turn over sebesar 3,63 (Kend/hari/ruang). Indeks tertinggi kedua kendaraan sebesar 115 % pada kendaraan roda dua. Strategi penanganan yang ditawarkan diantaranya adalah meningkatkan standar atau batasan jumlah maksimum parkir, pengawasan parkir yang lebih baik dan penambahan pintu keluar parkir untuk mengurai antrean kendaraan pengunjung yang akan keluar mall.
Pemanfaatan Material Limbah Tambang Emas dari Desa Tumbang Liting Sebagai Agregat pada Campuran Hot Rolled Sheet-Base (HRSBASE)
Authors: Desriantomy  , Lahasa Yubilate , Salonten
Published: August 2024

Central Kalimantan Province generally brings in materials from outside the region, such as Crushed Stone (Ex. Merak) for the need for pavement materials. This research determined the quality of gold mining waste materials in stone and sand from Tumbang Liting Village combined with Crushed Stone (Ex. Merak) as a mixture on Hot Rolled Sheet-Base (HRS-Base) pavement. From the results of Marshall testing and calculations, the Optimum Asphalt Content (KAO) value of 6.84%, Stability of 920.00 kg, Voids Between Aggregates (VMA) of 18.94%, Voids In The Mixture (VIM) of 4.00%, Voids Filled With Asphalt (VFA) of 78.90% and Marshall Quotient (MQ) of 260.00 kg/mm were obtained. The value of Marshall's characteristics shows that the use of gold mining waste material in stone and sand from Tumbang Liting Village has met the requirements for HRS-Base pavement so that the material can be used.
ABSTRAK
Provinsi Kalimantan Tengah umumnya mendatangkan material dari luar daerah seperti halnya Batu Pecah Eks.Merak untuk kebutuhan akan material perkerasan jalan. Penelitian ini dilakukan untuk mengetahui kualitas penggunaan material limbah tambang emas berupa batu dan pasir dari Desa Tumbang Liting yang dikombinasikan dengan Batu Pecah Eks.Merak sebagai campuran pada perkerasan Hot Rolled Sheet-Base (HRS-Base). Dari hasil pengujian Marshall dan perhitungan didapat nilai Kadar Aspal Optimum (KAO) sebesar 6,84%, Stabilitas sebesar 920,00 kg, Rongga Antar Agregat (VMA) sebesar 18,94%, Rongga Dalam Campuran (VIM) sebesar 4,00%, Rongga Terisi Aspal (VFA) sebesar 78,90% dan Hasil Bagi Marshall (MQ) sebesar 260,00 kg/mm. Nilai karakteristik Marshall tersebut menunjukkan bahwa penggunaan material limbah tambang emas berupa batu dan pasir dari Desa Tumbang Liting telah memenuhi spesifikasi pada perkerasan HRS-Base, sehingga material dapat digunakan.
Penerapan Skema Parkir Ganjil Genap di Kawasan Kampus
Authors: Althaf Muhammad , Joewono Tri Basuki , Hartieni Patricia
Published: August 2024

Availability of parking is one of the factors that determines whether someone wants to drive to a destination or not. This is due to limited parking space. Parking problems can be found anywhere, including the campus area. The density of parking lots in the campus area is due to the high number of students. One strategy to reduce the use of private vehicles is to place restrictions. This restriction can be an odd-even setting. This study aims to analyze student behavior in planning the implementation of odd-even parking schemes and to analyze student characteristics regarding parking space restriction strategies. The analysis results show that the student's decision to keep driving is influenced by the amount of pocket money and the time the policy is enforced. Correspondence analysis shows that the odd-even policy can be relied upon to reduce parking density, especially in the campus area.
ABSTRAK
Ketersediaan parkir adalah salah satu faktor yang menentukan apakah seseorang ingin berkendara ke suatu tujuan atau tidak. Hal ini disebabkan oleh keterbatasan lahan parkir. Masalah perparkiran dapat ditemukan dimana saja, termasuk area kampus. Kepadatan lahan parkir di area kampus disebabkan tingginya jumlah mahasiswa. Salah satu strategi dalam mengurangi penggunaan jumlah kendaraan pribadi adalah dengan melakukan pembatasan. Pembatasan ini dapat berupa pengaturan ganjil genap. Tujuan dari penelitian ini adalah menganalisis perilaku mahasiswa dalam perencanaan penerapan skema parkir ganjil genap dan menganalisis karakteristik mahasiswa terhadap strategi pembatasan lahan parkir. Hasil analisis menunjukkan bahwa keputusan mahasiswa untuk tetap membawa kendaraan dipengaruhi oleh besar uang saku dan jam pemberlakuan kebijakan. Analisis korespondensi menunjukkan bahwa kebijakan ganjil genap dapat diandalkan sebagai solusi untuk mengurangi kepadatan lahan parkir terutama di kawasan kampus.
Pengaruh Hambatan Samping Pengemis Terhadap Kenyamanan Pengguna Jalan pada Simpang Bersinyal Mall SKA Pekanbaru
Authors: Iswahyudi Ricky Dwi , Halim Muhammad Farid , Setyono Yahya Ramadan , Budiharjo Anton , Istiyanto Bambang
Published: August 2024

This research aims to determine (1) the influence of the presence of beggars on the comfort level of motorists at the SKA Mall Pekanbaru signalized intersection, (2) the factors that beggars prefer at signalized intersections as a place to beg, and (3) find solutions in resolving problems related to side obstacles, in the form of beggars at signalized intersections in Pekanbaru City. This research is experimental. Data was collected using interviews and questionnaires whose reliability and validity had been verified. Data analysis was carried out by calculating cycle time at intersections to determine the income of beggars. Finally, drivers' suggestions for beggars at signalized intersections are described in detail in the questionnaire results. The results of this research are (1) the presence of beggars disturbs the comfort and safety of motorists, (2) The factor causing the presence of beggars at Simpang Mall SKA Pekanbaru is because the average income of each beggar is IDR. 3,600,000.00 to Rp. 14,000,000.00/8 hours, and (3) the solution for beggars at signalized intersections is to enforce the law regarding controlling beggars and increase public awareness not to give beggars money.
ABSTRAK
Penelitian ini bertujuan untuk mengetahui  (1) pengaruh keberadaan pengemis terhadap tingkat kenyamanan pengendara di Simpang Bersinyal Mall SKA Pekanbaru, (2) faktor pengemis lebih memilih simpang bersinyal sebagai tempat untuk meminta – minta, dan (3) mencari solusi dalam penyelesaian masalah terkait hambatan samping berupa pengemis di simpang bersinyal Kota Pekanbaru. Penelitian ini adalah penelitian eksperimental. Pengumpulan data dilakukan dengan wawancara dan kuesioner yang telah diverifikasi reliabilitas dan validitasnya. Analisis data dilakukan dengan menghitung siklus waktu pada simpang untuk menentukan pendapatan pengemis. Terakhir, saran pengendara untuk pengemis di persimpangan bersinyal dideskripsikan secara rinci dari hasil kuesioner. Hasil penelitian ini adalah (1) keberadaan pengemis mengganggu kenyamanan dan keamanan pengendara, (2) Faktor penyebab keberadaan pengemis di Simpang Mall SKA Pekanbaru karena jumlah pendapatan yang tinggi rata-rata upah masing-masing pengemis adalah Rp. 3.600.000,00 sampai Rp. 14.000.000,00/8 jam, dan (3) solusi bagi pengemis di simpang bersinyal adalah menegakkan hukum tentang penertiban pengemis dan meningkatkan kesadaran masyarakat untuk tidak memberikan pengemis uang.
A Critical Discourse Analysis Of Religious Tolerance in ELT Textbook for Senior High School
Authors: Ikawati Fifi Nur , Setyono Budi , Rofiq Annur
Published: August 2024

This study was conducted to investigate how religious tolerance portrayed in ELT textbook for senior high school students for grade 10. The present study applied critical discourse analysis (CDA), framed in fairclough’s 3D model approaches in analyzing visual and textual artifact materials that represents the religious tolerance in the textbook. The findings showed that religious tolerance has very rare found in the textbook, which is represented 6 times through different images and oral text. The visual and textual data of religious tolerance contained in each textbook unit have been identified using the categories of fairness (F), respect (R1), and reasonableness (R2). The findings showed that there is still a lack of visual and verbal representation of religious tolerance in the textbook.
Avaliação do Efeito da Implementação de um Centro de Responsabilidade Integrado de Obesidade no Desempenho Hospitalar em Portugal
Authors: Carvalho Jorge , Campos Fernandes Adalberto
Published: August 2024

O aumento contínuo na prevalência da obesidade é um desafio ao nível global, em termos económicos e de saúde pública. Em Portugal, o tratamento da obesidade apresenta problemas acentuados no acesso aos serviços de saúde. Neste contexto, surge a necessidade de implementar e avaliar novos modelos de gestão que ofereçam respostas mais eficazes, como os centros de responsabilidade integrados. Este estudo tem como objetivo principal avaliar o impacto da implementação de um centro de responsabilidade integrado de obesidade no desempenho hospitalar. A pesquisa foi conduzida por meio de um estudo de caso múltiplo, predominantemente descritivo, mas com elementos também explanatórios. A abordagem metodológica é mista, combinando análises quantitativas e qualitativas. São avaliados indicadores de desempenho hospitalar, incluídos na dimensão do acesso, produção, eficiência, qualidade e económico-financeira, antes e após a implementação do novo modelo. Em termos globais a implementação de um centro de responsabilidade integrado de obesidade conduziu a melhorias no desempenho hospitalar nas dimensões avaliadas, sobretudo ao nível do acesso, produção e eficiência. Apesar de promissor, este novo modelo poderá beneficiar de um conjunto de melhorias em termos organizacionais, funcionais e jurídico-legais, como por exemplo no método de concessão de incentivos e no processo de financiamento. Nos casos analisados, este novo modelo de organização demonstrou ser uma solução para incrementar o desempenho hospitalar. Estas unidades podem desempenhar um papel estratégico fundamental no Sistema Nacional de Saúde, contribuindo para o acesso a tratamentos especializados, retenção de profissionais e sustentabilidade financeira.
A POPULATION-BASED STUDY ON THE DEMOGRAPHIC AND CLINICAL PARAMETERS AMONG CHILDHOOD LEUKEMIA SURVIVAL
Authors: Ali Nabihah , Saupin Saihpudin , Bahtiar Balqis , Shamsudin Shamsul Bahari
Published: August 2024

Introduction: Leukemia is the commonest childhood cancer among children aged 0-19 years in Malaysia, constituting approximately 39.1% of all pediatric cancer cases in the country. Aims: This study aimed to measure the characteristics and survival of childhood leukemia among the local Malaysian population. Methods: This was a retrospective cohort study based on all the childhood leukemia patients aged 0-19 years registered in the Malaysian National Cancer Registry between 2010 and 2014 with the date of death before or on the 31st December 2019. The Kaplan-Meier method and life table were used to estimate five-year survival rates. Statistical analysis was performed using SPSS (version 27). Result: A total of 1,212 participants were included in this study. Their mean (SD) age was 8 (5.6) at the time of diagnosis. The highest five-year survival estimates were seen in females (58%, 95% CI: 54.5-63.1), children aged 1 to 4 (66%, 95% CI: 62.3-70.9), Indian (61.6%, 95% CI: 50.2-73.0), children diagnosed with acute lymphoid leukemia (ALL) (65.7%, 95% CI: 61.6-69.8), and those who had undergone chemotherapy at diagnosis (57.3%, 95% CI: 54.0-60.6). Patients with childhood leukemia in Malaysia reported a 5-year overall survival of 56.4 %. Survival was greater in children aged 1 to 4 years old, Indians, with ALL, and have had chemotherapy treatment at the time of diagnosis. Conclusion: The study demographic and clinical findings were comparable with other Asian countries.
POLICY TO REDUCE UNDER TWO STUNTING IN EAST JAVA REGION, INDONESIA: WHO IS THE RIGHT TARGET?
Authors: Laksono Agung Dwi , Muis Early Wulandari , Wulandari Ratna Dwi
Published: August 2024

Introduction: Currently, 22% of children worldwide are stunted, and more than half live in Asia. Stunting in East Java is still high in several areas, which should have been prevented, given the relatively good resources. Aims: The study analyzes the policy targets for reducing stunting children in East Java. Methods: The study examined 4,541 children. The study analyzed nutritional status, residence, maternal (age, marriage, education, employment, socioeconomic, prenatal class), and child characteristics (age, gender, and early breastfeeding initiation (EIBF)). Results: Children in urban regions were likelier than those in rural regions to experience stunting. Stunted children were more prevalent among mothers of all ages compared to those <20. Lower education correlated with a greater likelihood of having stunted children. Stunted children were 2.410 times more prevalent among married mothers than divorced/widowed mothers (95%CI 2.292-2.534). Stunted infants were 1.062 times more prevalent among unemployed mothers compared to employed mothers (95%CI 1.050-1.075). All socioeconomic levels have a higher probability than the wealthiest to experience stunting. Mothers with prenatal classes were 1.088 times more likely than those without to have stunted kids (95%CI 1.073-1.103). Children aged 12-23 had a greater likelihood of developing stunting than those younger than <12. Boys were 1.286 times more likely than girls to experience stunting (95%CI 1.272-1.300). Children with EIBF had a 1.081 times higher likelihood of experiencing stunting than those without (95%CI 1.069-1.093). Conclusion: The appropriate policy targets for reducing the stunting prevalence were mothers in urban areas, young age, married, poor educated, unemployed, and poor.
RISK FACTOR ANALYSIS OF INCOMPLETE BASIC IMMUNIZATION IN CHILDREN AGED 12-23 MONTHS IN EAST NUSA TENGGARA PROVINCE
Authors: Almeida Denisca , Benyamin Bebengu Yahya , Syahrul Fariani , Hargono Arief
Published: August 2024

Introduction: Immunization is an effective effort to prevent some dangerous diseases in children. By providing complete basic immunization, it can reduce child mortality. East Nusa Tenggara province reached a low number of complete basic immunization coverage in 2016 (69.29%), increased in 2017 (72.2%), then decreased again in 2018 (51.72%).Aims: of this study is to analyze risk factors for incomplete immunization status in children aged 12-23 months in NTT province. Method. The method used is analytical observational with a cross-sectional design. The data used are  secondary data of Basic Health Research 2018. The study population was household members who could be interviewed at the time of Basic Health Research 2018 in the NTT provincial census block area. Total sample was 674 households. The sampling technique used is two stage one phase stratified sampling. The independent  variables include mother's age, father's age, mother's education level, father's education level, number of children, residence, AEFI, and ANC. The dependent variable is the incomplete basic immunization status. Results: In this study, it is known that the candidate in the regression test variables are father's age (p value= 0.005), mother's educational level (p value= 0.000), number of children (p value= 0.007), residence (p value= 0.000), and ANC (p value= 0.000). Conclusion: According to this study,  most children under two years were not fully immunized (63.2%). And in this research, the candidate variables will then become a prediction model of incomplete immunization status in children 12-23 months in East Nusa Tenggara  province.
ONLINE APPLICATION BASED ON KING INTERACTION SYSTEM THEORY TO INCREASE TREATMENT ADHERENCE AND CLINICAL INDICATORS IN TB CHILDREN
Authors: Sari Ethyca , Nur Kristina Tri , Sujianto Untung , Suhartono  , Sakti Hastaning
Published: August 2024

Introduction:  Non-adherence to treatment among TB children in Indonesia varied 40.5%-57.2%. An innovative method of education might improve treatment adherence and clinical recovery of TB children. The aims of this study were to compare the treatment adherence and clinical indicators of TB children who received an intervention using an online application based on King's theory with a conventional method. Methods: This is a quasi-experimental study to educate 55 TB school-age children using a validated online application based on King's interaction system theory, compared with the conventional method in 55 TB children as the control group. The medication regularity and control discipline were observed four times in weeks 2, 4, 6, and 8. Measurements of acid-fast bacilli (AFB) smear sputum examination, TB scoring, chest X-ray examination, level of Hb, and nutritional status were done twice in pre- and post-intervention. Data analysis used chi-square, paired t-test, independent t-test, Mann Whitney, McNemarᵇ. or Wilcoxon test. Results: The results of this study revealed that the intervention group was significantly successful compared to the control group in several indicators, such as increasing treatment adherence (p=0.001), controlling discipline (p=0.001), reducing AFB positive (p=0.001), TB scoring (p=0.001), infiltrate in chest X-ray examination ((p=0.013), and increasing Hb levels (p=0.001). Meanwhile, nutritional status could not be compared because, from the beginning of the study, the nutritional status was unbalanced and benefited the intervention group. Conclusion: The online application based on King's theory has succeeded in increasing medication adherence and clinical improvement of pulmonary TB in children.
Estimation of population structure in emmer wheat germplasm conserved in the National Genebank of India
Authors: Tanwar Jatin , Tyagi Sandhya , Sharma Shivani , Jakhar Preeti , Kumar Gaurav , Jacob Sherry R. , Singh Amit Kumar , Jha Shailendra K. , Kumari Jyoti
Published: August 2024

Emmer wheat germplasm has received little attention with regard to exploring its genetic diversity toward enhancing utilization. Agro-morphological characterization was performed on 192 emmer wheat accessions during the winter season of 2019–2020, and subsequently 96 accessions were selected for morphological and molecular diversity analysis during the winter season of 2020–2021. Genetic diversity and population structure of 96 diverse Triticum dicoccum genotypes conserved in the National Genebank of India were estimated using 56 microsatellite (simple sequence repeat) markers. The number of alleles per locus ranged from one to six, with an average of 1.68 alleles. A total of 93 alleles were detected, with the highest polymorphic information content value (0.9912) observed for the Xcfd20 marker. Based on ‘STRUCTURE’ analysis, 96 dicoccum accessions were divided into two subpopulations. The analysis of molecular variance revealed that genetic differentiation among subpopulations was low and within subpopulations was high. A cluster analysis based on Jaccard’s dissimilarity index identified two clusters which were in congruence with the population structure. Indigenous and exotic collections were categorized into distinct subclusters within the same cluster with some overlapping suggesting limited genomic differentiation between these collections. Based on the present study, it is evident that cultivated emmer wheat showed low genetic diversity and a narrow genetic base. This might be due to limited cultivation in small pockets and emphasizes a need to broaden the genetic base of emmer wheat genetic resources for enhanced utilization.
Ovarian clear cell carcinoma: research progress in oncogenesis and novel therapeutic strategies
Authors: Duan Fangqian , Sun Mingming , Chen Xiaojun , Jiang Wei
Published: August 2024

Clear cell carcinoma of the ovary exhibits distinct biological characteristics and clinical behaviors. Compared to other epithelial ovarian tumors, there are notable geographical and racial variations in its incidence. Patients diagnosed with clear cell carcinoma are typically younger, often presenting at an early disease stage, and frequently have a history of endometriosis. The most prevalent and consequential genetic mutations associated with clear cell carcinoma involve the AT-rich interactive domain 1A and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. Studies in gene expression profiling have revealed an upregulation of hepatocyte nuclear factor-1β and genes related to oxidative stress. Furthermore, these studies have delineated distinct tumor subgroups characterized as epithelial-like and mesenchymal-like. While the efficacy of platinum-based chemotherapy in clear cell carcinoma remains somewhat ambiguous, it remains the cornerstone of initial treatment. Patients with early-stage disease generally experience favorable clinical outcomes. Conversely, those with advanced-stage or recurrent disease face a poor prognosis. Active exploration into the molecular mechanisms underlying this carcinoma and the development of alternative treatment strategies is imperative to enhance patient outcomes. Targeted therapies based on molecular profiles show promise in this endeavor.
Investigating the Extent and Nature of the Primate Pet Trade on TikTok
Authors: Collins Daisy , Campera Marco
Published: August 2024

With online wildlife trade increasing and viral videos increasing demand, the trade in primates on TikTok is becoming more prevalent. Despite wildlife trade being banned on most social media platforms, the trade in primates persists. TikTok’s policies ban the sale of live animals, and specific terms related to wildlife trade are banned; however, these search term bans are easy to get around, and sellers are still prolific on the site. This study documented primates for sale on TikTok using the search term “for sale monkey” over a four-month period (from mid-July to mid-November 2023) with the aim of determining how widespread primate trade is on TikTok, the legality of advertisements, and which countries advertise the most primates for sale. 42 individual advertisements were identified, spanning 6 different genera of primates and 5 different countries. Spider monkeys, rhesus macaques, and common marmosets were found to be the most commonly advertised species on TikTok. All spider monkeys were advertised from the USA, while the majority of the marmosets were advertised from the UK, and all of the rhesus macaques were advertised from Pakistan. The USA was the only country identified in this study that advertised a range of species, and the only species found in this study that was not advertised in the USA was the mona monkey. 44% of all species recorded were classified as either Endangered or Critically Endangered, and it was found that endangered species were more frequently sold illegally than non-endangered species. The findings of this study underline a need for stricter primate legislation and wildlife law enforcement, especially if the UN’s sustainable development goals are to be achieved by 2030. They also show a need for TikTok to broaden their restrictions on wildlife trade on their app.
On the Sapir-Whorf Hypothesis, Innateness Hypothesis and Semiotics
Authors: Penzance Isaac
Published: August 2024

This article considers a different application of similar methods that have been used to reject the Sapir-Whorf Hypothesis and expounds the idea as a member of the cumulative proof against the theory. Rather than to explicitly include models of generative grammars, this model instead does not violate the ideas of Optimality Theory – and therein it preserves such qualities as freedom of analysis while retaining the idea of the pertinent constraints. However, it is suggestive of momentary disagreements with the Innateness Hypothesis.
Trust Your Generator: Enhancing out of Model Scope Detection
Authors: Diviš Václav , Spatz Bastian , Hrúz Marek
Published: August 2024

Recent research has drawn attention to the ambiguity surrounding the definition and learnability of Out Of Distribution (OOD) recognition. The term "Out of Model Scope" (OMS) detection provides a clearer perspective, although the original problem remains unsolved. The ability to detect OMS inputs is particularly beneficial in safety-critical applications such as autonomous driving or medicine. By detecting OMS situations, we not only enhance the system's robustness but also prevent it from operating in unknown and unsafe scenarios. In this paper, we introduce a novel approach for OMS detection that combines three sources of information: 1) the original input, 2) the latent feature space extracted by an encoder, and 3) the synthetic data generated from the encoder's latent feature space. We demonstrate the effectiveness of combining original images and synthetically generated images against adversary attacks in the computer vision domain. We achieve results comparable to other state-of-the-art methods and demonstrate that any Encoder can be integrated into our pipeline in a plug-and-train fashion. Our experiments further evaluate which combination of the Encoder's features works best in order to discover OMS samples and highlight the importance of a compact feature space for the training of the Generator.
Ferrer House at Rocafort, an Early Case of Design Brise-Soleil for the Mediterranean in Valencia
Authors: Gómez-Gil Antonio , Cabeza-Lainez Joseph
Published: August 2024

In 1944 the architect Antonio Gómez Davó designed and built a new house for Mr. Ferrer at Rocafort in the suburbs of Valencia (Spain). In this same year, Europe, America, Russia and even Japan were still at war and Spain was only recovering from its own intestine conflict. Therefore, architectural innovations and influences were scarce as was the circulation of specialized journals on the matter. But in many creations, like the ceramic vaults and the brise-soleil, Le Corbusier himself had declared his profound nostalgia from the Mediterranean, a Sea that he had come to appreciate in his travels to the “orient”. In the case of Gómez Davó, having been born and raised in a prominent family of Valencia he could not remain indifferent to the design features that appeared in the vernacular architecture of the area, specially the type of inclined louvers of Arabic descent, that covered bow-windows and balconies and which have come to be known in Spain as the Majorcan louvers; nowadays even employed by Rafael Moneo for instance at the extension of the Painter Miro Foundation. However, with so many difficult circumstances surrounding him, Gómez Davó could not get to the point of producing a ground breaking design based on solar assumptions for the whole façade of the building, instead when providing an entrance porch apt for spending life, meals and well deserved rest hours outdoors in the pure Mediterranean tradition, he ventured to construct a surprising perforated wall oriented to the South in order to control radiation in winter and provide shade in the summer while affording excellent light and superb conditions of ventilation. By means of our own devised simulation tools we have analyzed the conditions of the house and especially of such innovative brise-soleil at times reminiscent of Alvar Aalto solutions for day-lit roofs, which he was aware intuitively and by his own incipient study of solar geometry, that needed adaptation from so distant latitudes as Finland and Valencia. By outlining such unknown and bold precedent we contribute to revitalize the early and daring pioneers of solar architecture in peripheral Spain and Europe, at the birth of critic regionalism, a fact often disregarded in conventional history of Modern Architecture.
Viruses Identified in Shrews (Soricidae) and Their Biomedical Significance
Authors: Gong Huan-Yu , Chen Rui-Xu , Tan Su-Mei , Wang Xiu , Chen Ji-Ming , Zhang Yuan-Long , Liao Ming
Published: August 2024

Shrews (Soricidae) are common small wild mammals. Some species of shrews, such as Asian house shrews (Suncus murinus), have a significant overlap in their habitats with humans and domestic animals. Currently, over 190 species of viruses in 32 families, including Adenoviridae, Arenaviridae, Arteriviridae, Astroviridae, Anelloviridae, Bornaviridae, Caliciviridae, Chuviridae, Coronaviridae, Filoviridae, Flaviviridae, Hantaviridae, Hepadnaviridae, Hepeviridae, Nairoviridae, Nodaviridae, Orthoherpesviridae, Orthomyxoviridae, Paramyxoviridae, Parvoviridae, Phenuiviridae, Picobirnaviridae, Picornaviridae, Polyomaviridae, Poxviridae, Rhabdoviridae, Sedoreoviridae, Spinareoviridae, and three unclassified families, have been identified in shrews. Diverse shrew viruses, such as Borna disease virus 1, Langya virus, and severe fever with thrombocytopenia syndrome virus, cause diseases in humans and/or domestic animals, posing significant threats to public health and animal health. This review compiled fundamental information about shrews and provided a comprehensive summary of the viruses that have been detected in shrews, with the aim of facilitating a deep understanding of shrews and the diversity, epidemiology, and risks of their viruses.
Parallel Numerical Solution of 2D Electrostatics Poisson Equation on Different Mesh Partitioning Schemes
Authors: Kamboh Shakeel Ahmed , Khanam Faiza , Naeem Nadeem , Parveen Sajida , Kamboh Sakina , Kamboh Safina
Published: August 2024

The ideas of parallelism for the large scale problems or problems with dense meshes have gained much attention in last few decades. The key goal of applying the parallelization is to reduce the computational time. In this paper; the 2D finite difference mesh partitioning schemes and their effect on performance of parallel numerical solution is evaluated. The main objective was to investigate the mesh partitioning schemes for less computational time and high speedup. For testing and implementation purpose a 2D electrostatics Poisson’s equation with Dirichlet and Neumann boundary conditions applied on a 2D cross section of Electrohydrodynamic (EHD) planar ion-drag micropump is used to simulate the electric potential and electric field on a parallel system. The performance of the 7 different mesh partitioning schemes (PS) in terms of computational time, speedup, efficiency and communication cost was evaluated. It was revealed that among the seven different partitioning schemes the PS-3 (two-way or tile partitioning) is found the best scheme for the parallel numerical simulation of the problem. Moreover, the parallel algorithm remains more efficient on \(P=2\) to \(P=8 \) workers while for \(P>8\) the efficiency of the algorithm may drop because of the high communication time.
ULUR-ULUR TRADITION
Authors: Hendra Afiyanto  , Sun Mingyue
Published: August 2024

This study was made to construct the Ulur-Ulur tradition that emerged during the Majapahait period. The Ulur-Ulur tradition has passed through several periods of time, it is certainly interesting to study why it is still existence until now. The Ulur-Ulur tradition was still existence until the time of Islamic domination. What is the preservation of the Ulur-ulur tradition related to his ability to read discourse in each period? So that it has a different discourse in each period? or the existence of the Ulur-Ulur tradition due to the tolerance of the predominantly Islamic local community towards the previous culture? On the other hand, did the Ulur-Ulur tradition also negotiate itself from Islamic domination? This research uses historical and ethnographic methods. This study has three findings, first: the existence of the Ulur-Ulur tradition because of its ability to read discourse in each era, so that the Ulur-Ulur tradition has various meanings. Second, the tolerance of the majority Islamic community also maintains the existence of the Ulur-Ulur tradition. Third, the negotiation between the Ulur-ulur tradition and Islam, is also the key to the existence of tradition, the form of negotiation can be seen from the meaning of the offering.
Shallow-water Mussels Adapt to Deep-Sea Environment Through Transcriptomic and Metagenomic Insights
Authors: Sun Luyang , Liu Xiaolu , Zhou Li , Wang Hao , Lian Chao , Zhong Zhaoshan , Wang Minxiao , Chen Hao , Li Chaolun
Published: August 2024

Recent studies have unveiled the deep sea as a rich biosphere, populated by species descended from shallow-water ancestors post-mass extinctions. Research on genomic DNA evolution and microbial symbiosis has shed light on how these species thrive in extreme deep-sea conditions. However, early adaptation stages, particularly the roles of conserved genes and symbiotic microbes, remain inadequately understood. This study examined transcriptomic and microbiome changes in shallow-water mussels exposed to deep-sea conditions at the Site-F cold seep in the South China Sea, at a depth of 1,119 m. Results reveal complex gene expression adjustments in stress response, immune defense, homeostasis, and energy metabolism pathways during adaptation. After 10 days of deep-sea exposure, shallow-water mussels and their microbial communities closely resembled those of native deep-sea mussels, demonstrating host and microbiome convergence in response to adaptive shifts. Notably, methanotrophic bacteria, key symbionts in native deep-sea mussels, emerged as a dominant group in the exposed mussels. Host genes involved in immune recognition and endocytosis correlated significantly with the abundance of these bacteria. Overall, our analyses provide novel insights into adaptive transcriptional regulation and microbiome dynamics of mussels in deep-sea environments, highlighting the roles of conserved genes and microbial community shifts in adapting to extreme environments.
A Simplified Liver Perfusion Model, with Applications to Organ Preservation
Authors: Emerson Daniel , Rabin Yoed , Kara Levent Burak
Published: August 2024

Advanced liver preservation strategies could revolutionize liver transplantation by improving access and restoring function to marginal livers. However, developing new cryopreservation protocols requires exploration of a complex design space, further complicated by the scarcity of real human livers to experiment upon. We aim to create computational models of the liver to aid in the development of new cryopreservation protocols. Towards this goal, we present an approach for generating 3D models of the liver vasculature by building upon the space colonization algorithm. Additionally, we introduce the concept of a super lobule which enables a computational abstraction of biological liver lobules. User-tunable parameters allow for vasculatures of varying depth and topology to be generated. In each model, we solve for a common lumped resistance value assigned to the super lobules, allowing the overall physiological blood pressure and flow rate through the liver to be preserved. We demonstrate our approach's ability to maintain consistency between models of varying fidelity. Next, we simulate steady state machine perfusion of the generated models and highlight similarities with experimental observations. Lastly, we demonstrate how the models can be used to quickly test the effect of different boundary conditions when designing perfusion protocols.
Putting piezoelectric sensors into Fano resonances
Authors: Huang Qing-An , Wang Mengting , Huang Jianqiu
Published: August 2024

Piezoelectric resonance sensors are essential to many diverse applications associated with chemical and biological sensing. In general, they rely on continuously detecting the resonant frequency shift of piezoelectric resonators due to analytes accreting on their surfaces in vacuum, gas or fluid. Resolving the small analyte changes requires the resonators with a high quality factor. Here, we propose theoretically and demonstrate experimentally a scheme using a physics concept, i.e., a Fano resonance, to enhance the quality factor rather than optimizing the structure and material of the resonator itself though these are important. The Fano resonance arises due to the interference between a discrete mode and a continuum of modes, leading to the asymmetric and steep dispersion. In our scheme, the as-fabricated piezoelectric sensors are put into the Fano resonance by connecting an external shunt capacitor to them. As a verification case, one-port surface acoustic wave (SAW) resonators on LiNbO3 substrate, incorporating a composite of polymethyl methacrylate (PMMA) and graphene oxide (GO) for humidity sensing, have been fabricated and characterized. We enhance the quality factor by up to a factor of about 8, from 929 for the as-fabricated sensor to 7682 for that with the external shunt capacitor. Our results pave the way for the practical development of piezoelectric resonance sensors with high quality factor.
Temporal Co-Occurrence in a Community of Subtropical Australian Birds
Authors: Hudson Nicholas J.
Published: August 2024

I aimed to better understand the community ecology of sympatric birdlife in subtropical South East Queensland, Australia using patterns of temporal species co-occurrence and principles from network theory. In line with expectation, a hierarchical clustering analysis showed that sampling dates that were successive possesed similar patterns of observed bird species. Interestingly, there is an example of total observed bird biomass being almost identical (38 kg) on successive days in September, but comprising 36 species on the first day yet only 8 on the second, the latter date being dominated by biomass from a single species (Australian Pelican, Pelicanus conspicillatus). Ranking each species on its average pairwise correlation to the other 87 species in the set shows that, unsurprisingly, raptors (such as Whistling Kites, Haliastur splenurus) tend to be enriched at the extreme negative end of the list (hypergeometric enrichment statistic P = 0.00029) indicating their presence is inhibitory to other avian species. On the other hand, Silvereyes (Zosterops lateralis) possess the highest number of total connections, the highest radiality (or ‘network influence’) metric within the inferred co-occurrence network and have the second highest average positive correlation to all other bird species in the set (+0.32). Collectively, this suggests Z. lateralis can be seen as an indicator species whose presence indicates an enhanced likelihood of observing a diversity of other bird species. The use of the PCIT network reconstruction algorithm is demonstrated in ecology for the first time.
Operando spin observation elucidating performance-improvement mechanisms during operation of Ruddlesden–Popper Sn-based perovskite solar cells
Authors: Marumoto Kazuhiro , Chen Yizhou , Yamaguchi Seira , Sato Atsushi , Xue Dong
Published: August 2024

Sn-based perovskite solar cells (PSCs) have attracted attention because of their low environmental impact. Unfortunately, the readily occurring oxidation of Sn2+ inhibits further improvement of their efficiency and stability. Ruddlesden–Popper (RP) Sn-based perovskites are considered promising candidates as absorbers that improve the performance and stability of Sn-based PSCs. However, microscopic understanding of performance-enhancing mechanisms remains insufficient. For this study, electron spin resonance (ESR) spectroscopy measurements were taken of RP Sn-based PSCs with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hole-transport layers and (BA0.5PEA0.5)2FA3Sn4I13 perovskite layers to clarify the space-charge region formation mechanism at the PEDOT:PSS/(BA0.5PEA0.5)2FA3Sn4I13 interface. Results indicated electron-barrier formation in the (BA0.5PEA0.5)2FA3Sn4I13 layer near the PEDOT:PSS layer. Moreover, the electron barrier was found to be enhanced during device operation. The enhanced interface band bending reduces interface recombination and thereby improves the device performance. These findings might provide important progress in practical applications of PSCs and might advance the realization of a carbon-neutral society.
Pathogen delivery route impacts disease severity in experimental co-infection of sheep with Mycoplasma ovipneumoniae and Mannheimia haemolytica
Authors: Jacobson Bryan Tegner , Jessica DeWit , LaShae Zanca , Sonar Sobha , Hardy Carol , Throolin Michael , Brewster Patricia , Andujo Kaitlyn , Jones Kerri , Sago Jonathon , Smith Stephen , Bowen Lizabeth , Bimczok Diane
Published: August 2024

M. ovipneumoniae is a respiratory pathogen that can cause mild to moderate pneumonia and reduced productivity in domestic lambs. However, studies on both natural and experimental M. ovipneumoniae infection have reported highly variable clinical signs and pathology. Here, we assessed the impact of administering M. ovipneumoniae to the upper respiratory tract (URT) or to the lower respiratory tract (LRT) of two-months-old specific pathogen-free lambs. Lambs were inoculated with PBS (control) or with ceftiofur-treated nasal wash fluid obtained from sheep with natural M. ovipneumoniae infection, monitored for eight weeks, and subsequently euthanized. All lambs in the URT and LRT groups developed a stable infection with M. ovipneumoniae. M. ovipneumoniae infection led to lower weight gains and mild respiratory disease, with significantly greater effects following LRT inoculation compared to URT inoculation. At necropsy, lambs inoculated via the LRT showed consolidation of the cranial and alveolar, bronchiolar, and interstitial inflammation that was significantly more severe in the LRT compared to the URT group. M. ovipneumoniae loads in the trachea and bronchi also were significantly higher after LRT than URT inoculation. Interestingly, 9/10 inoculated lambs also tested positive for M. haemolytica in nasal swab but not in bronchial swab samples. In summary, our study suggests that bypassing protective mechanisms of the URT by delivering respiratory pathogens to the LRT leads to more severe respiratory disease and lung damage than delivery to the URT. We also confirmed that M. ovipneumoniae significantly enhances the susceptibility of lambs to secondary respiratory pathogens such as M. haemolytica.
Genome-wide identification of Aux/IAA gene family in grape and functional analysis of VaIAA3 in response to cold stress
Authors: Lu Shixiong , Li Ming , Chen Yongjuan , Gou Huiming , Che Lili , Liang Guoping , Mao Juan
Published: August 2024

The Aux/IAA gene is a key gene that regulates auxin signal transduction in plants. Although IAA genes have been characterized in various plant species, the role of the IAA gene in grape cold resistance is unclear. In order to further explore the members of Aux/IAA gene family in grape and their functions, in this study, based on the genomic data of ‘Pinot Noir’ (Vitis vinefera cv. ‘Pinot Noir’) and Shanputao (Vitis amurensis), 25 VvIAA genes and 18 VaIAA genes were identified. The VaIAA genes exhibited different expression patterns under diferent temperature periods by qPCR. VaIAA3 was selected as a candidate gene for further functional analysis because of its high expression level under low temperature stress. The subcellular localization showed that VaIAA3 was localized in the nucleus. Additionally, under 4℃ treatment at 24 h, the relative expression level of VaIAA3, antioxidant enzyme activity, survival rate, and cold responsive genes of the three transgenic lines (OE-1, OE-2, OE-3) were higher, while the contents of relative electrolytic conductivity (REC), malondialdehyde (MDA) and hydrogen peroxide (H2O2) were lower under cold stress. Transcriptome sequencing analysis revealed that the regulation of low temperature resistance in Arabidopsis thaliana (Arabidopsis) by VaIAA3 may be related to auxin, ABA and ethylene. Importantly, heterologous over-expression of VaIAA3 can enhance resistance of Arabidopsis under cold stress, which provides a theoretical basis for further use of IAA3 gene to improve grape agronomic traits.
SYVN1 aggravates esophageal squamous cell carcinoma development by facilitating macrophage M2 polarization and activating NF-κB pathway
Authors: Wang Kang , Yang Nan , Qiu Yuan , Huang Zhao , Shen Yi , Luo Jing
Published: August 2024

Esophageal squamous cell carcinoma (ESCC) is a leading lethal cancer in the digestive system. Tumor-associated macrophages (TAMs) are key participators in ESCC progression. Mounting evidence has testified the regulatory function of Synoviolin (SYVN1) in cancer development. However, the correlation between SYVN1 and TAM polarization remains unclear. As a result, the goal of the present study was to shed light on the new mechanism of SYVN1 in ESCC. It was found that SYVN1 was upregulated at mRNA and protein levels in tissue samples and cells of ESCC. Knockdown of SYVN1 attenuated the malignant behaviors of ESCC cells in vitro and in vivo. Of note, we verified that silencing SYVN1 contributed to the polarization of TAMs into M1 subtype. Moreover, our findings demonstrated that SYVN1 mediated cell pyroptosis through modulating TAM polarization. More than that, we explored the relationship between SYVN1 and pivotal modulatory factors of NF-κB signaling pathway. Our observations revealed that SYVN1 directly bound with DEAD-box helicase 5 (DDX5) and eukaryotic translation elongation factor 1 alpha 2 (eEF1A2) to enhance their expression. Besides, silencing of SYVN1 inhibited the activation of nuclear factor kappa B (NF-κB) pathway, and overexpression of DDX5 or eEF1A2 abolished the role of SYVN1 deficiency in NF-κB pathway. Overall, this study illustrated that SYVN1 induced ESCC progression by promoting the M2 polarization of TAMs and activating NF-κB pathway.