bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Ukuran Perusahaan, Debt To Equity Ratio, Current Ratio, Dan Return On Asset Terhadap Nilai Perusahaan Pada Perusahaan Makanan Dan Minuman Yang Terdaftar Di Bursa Efek Indonesia Periode 2017-2020
Authors: Yuliana Yuliana , Jocelyn Jocelyn , Kurniawan Alex
Published: September 2023

This study aims to analyze the variables mentioned above in relation to the market capitalization of food and beverage companies listed on the Indonesia Stock Exchange between 2017 and 2020. The research strategy used is quantitative. This study uses a purposeful selection strategy to select 12 banking institutions that have been listed on the Indonesia Stock Exchange within four years before the research began. Researchers observe that company size, debt to equity ratio, current ratio, and return on assets all have a significant simultaneous effect on food and beverage companies listed on the Indonesia Stock Exchange between 2017 and 2020 scores. Companies involved in the food and beverage industry are listed on the Indonesia Stock Exchange will have a value that fluctuates in part depending on its size between 2017 and 2020. Between 2017 and 2020, the stock prices of food and beverage companies listed on the Indonesia Stock Exchange Exchange have a sizeable correlation with their debt-to-equity ratio . No statistically significant effect of the current ratio in the market can be seen for 2017-2020. companies involved in the production and distribution of food and beverages in Indonesia, as measured by their market value on the Indonesia Stock Exchange. Food and beverage companies traded on the Indonesia Stock Exchange saw less impact on their return on assets on their share prices between 2017 and 2020.

Keywords: Company Size, Debt To Equity Ratio, Current Ratio, Return On Assets,  Company Value
PENGEMBANGAN MEDIA ADOBE FLASH BERBASIS KONTEKS LUBUKLINGGAU DITINJAU DARI SEGI KEVALIDAN
Authors: Anggraini Lissa , Refianti Rani , Adha Idul
Published: September 2023

This study aims to produce a context-based mathematics learning media in Lubuklinggau using a valid Adobe Flash application. This research is a development research using the ADDIE model. This model consists of 5 stages, namely: the analysis stage (Analyze), planning (Design), development (Development), implementation (Implementation), and evaluation (Evaluation). Data collection was carried out using a questionnaire sheet and a walkthrough. Based on the results of the assessment analysis by three experts, namely: linguists, material experts, and media experts, it showed that the Lubuklinggau context-based mathematics learning media using the Adobe Flash application met the valid criteria with an average score of 4.05.
PENERAPAN MEDIA KARTU BILANGAN PADA PEMBELAJARAN MATEMATIKA SISWA KELAS II SD NEGERI 4 MEGANG SAKTI
Authors: Avrianti Tika , Rosalina Elya , Aswarliansyah Aswarliansyah
Published: September 2023

The research objective was to determine the completeness of learning outcomes in the application of number card media in mathematics learning for grade II students of SD Negeri 4 Megang Sakti. This research method uses an experimental research method with a quasi-experimental design with the categories of pre-test and post-test group. The subjects of this study were 11 grade students of SD Negeri 4 Megang Sakti. The data collection technique uses a test technique in the form of 6 essay questions. The data were analyzed using the "z" test formula. Based on the data analysis, it is known that the results of the pre-test with an average value of 41.591 and the final test (post-test) score of 83.364. Based on the results of hypothesis testing, then zcount is compared with zcount with a significant level of α = 0.05, obtained z_hitung 11.036 and z_table 1.645, then z_hitung 11.036> z_table 1.645 with this, H_a is accepted and H_O is rejected. So it can be concluded that the application of the number card media for the learning outcomes of grade II SD Negeri 4 Megang Sakti is significantly complete.
The effect of myelopathic symptoms on hospital costs, length of stay, and discharge location in anterior cervical discectomy and fusion
Authors: Porche Ken , Vaziri Sasha , Stein Alan , Awan Omar , Kubilis Paul S. , Lipori Paul , Hoh Daniel J. , Polifka Adam , Fox W. Christopher
Published: September 2023

OBJECTIVE

Cervical spondylotic myelopathy (CSM) is a common clinical degenerative disease treated with anterior cervical discectomy and fusion (ACDF), which seriously impacts quality of life and causes severe disability. The objective of the study was to determine the effect of different characteristics of the neurological deficit found in myelopathic patients undergoing ACDFs on hospital cost, length of stay (LOS), and discharge location.

METHODS

This is a retrospective review of ACDF cases performed at a single institution by multiple surgeons from 2011 to 2017. Patient symptomatology, complications, comorbidities, demographics, surgical time, LOS, and discharge location were collected. Patients with readmissions or reoperations were excluded. Symptoms evaluated were based on clinical diagnosis, Japanese Orthopaedic Association classification, Ranawat grade, and Cooper scales. Symptoms were further grouped using principal component analysis. Cost was defined as surgical episode hospital stay costs plus outpatient clinic costs plus discharge disposition cost. Multivariate linear regression models were created to evaluate correlations with outcomes. The primary outcome was total 90-day hospital costs. Secondary outcomes were discharge location and LOS.

RESULTS

A total of 250 patients were included in the analyses. Discharge location, neuromonitoring use, number of surgical vertebral levels, cage use, LOS, surgical time, having a complication, and sex were all found to be predictive of total 90-day costs. Myelopathic symptomatology was not found to be associated with increased 90-day costs (p ≥ 0.131) when correcting for these other factors. Lower-extremity functionality was found to be associated with increased LOS (p < 0.0001). Upper-extremity myelopathy was found to be associated with increased discharge location needs (p < 0.0001).

CONCLUSIONS

Cervical myelopathy was not found to be predictive of total 90-day costs using symptomatology based on multiple myelopathy grading systems. Lower-extremity functionality was, however, found to predict LOS, while upper-extremity myelopathy was found to predict increased discharge location needs. This implies that preoperative deficits from myelopathy should not be considered in a bundled payment system; however, certain myelopathic symptoms should be considered when determining the cost of care.
Kinetical Study of Adsorption Active and Non Activated Carbon from Chocoa Skin in Methyl Violet Solution
Authors: Hartono Tri , Murdiningsih Hastami , Amri Amri , Nurhayati Nurhayati , F Ramadhani
Published: September 2023

Methyl violet solution has particular color and mostly used to coloring in textiles industry and traditional cloth making.Â  The liquid wastes containing this color can be reduces or removed by several methods, one of which is by adsorption using carbon as an adsorbent. The chocoa plant is abundant in Indonesia while its fruit consists of 60.67% lignin, 36.47% selulosa and 18.90% hemiselulosa [1]. Hartono et al. [2 &3] reported cassavaâ€™s skins contain protein, cellulose and crude fiber can be used as basic material (similarly with chocoa skin) of producing active carbon. This research is to develop more on reducing methyl violet (as particular color) containing in liquid waste by adsorbent from chocoa skin with variation of reaction time between active carbon and non-activated carbon for constant particle sizes of 48 Mesh (-425/+250 mm), and also to study the kinetical reaction of chocoa skin active carbon and non-activated carbon for adsorbing methyl violet in term of Freundlich and Langmuir isotherm equations. The result shows the kinetical adsorption of both active and non-activated carbon from chocoa skin as adsorbent follows Langmuir isotherm equation with adsorption capacity of 579.91 mg/g and 338.94 mg/g respectively.Â
An den Nationalsozialismus erinnern
Authors: Friebel Harry
Published: September 2023

Was war der Holocaust damals und wie wirkt der Holocaust heute noch? Harry Friebel betrachtet den Themenkomplex „Erinnerungskultur“ aus einer interdisziplinären Perspektive und untersucht Motivationen, Bedeutungen und Interessenlagen auf verschiedenen Ebenen. Besondere Aufmerksamkeit wird der Wechselseitigkeit von Täter- und Opferperspektive innerhalb der NS-Diktatur und im Leben der Nachkommen in einer multikulturellen Moderne gewidmet. Abschließend diskutiert der Autor die Frage, wie eine Erinnerungskultur für die Zukunft aussehen kann.
Nigeria: die regionale Führungsmacht in Westafrika
Authors: Sedzro Paul
Published: September 2023

Nigeria ist einer der einflussreichsten Akteure in Afrika. Das Land agiert als wichtiger Player in den internationalen Beziehungen und tritt als regionale Führungsmacht in der Westafrikanischen Wirtschaftsgemeinschaft (ECOWAS) auf. Die Studie analysiert Nigerias Führungsrolle innerhalb der ECOWAS, insbesondere in der regionalen Sicherheitspolitik. Im Fokus steht dabei die Frage, inwieweit Nigerias Innenpolitik die Leistungsfähigkeit der ECOWAS bei der Bewältigung von Konflikten und Krisen in Westafrika beeinflusst.
The Impact of Dose Reduction of Bacillus Calmette–Guerin on Oncological Outcomes and Toxicity in Non-Muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis
Authors: Azuri Wadi , Jaunarena Jorge Horacio , Camean Juan Jorge , Chemi Joaquín , Villaronga Alberto , Daneshmand Siamak , Villoldo Gustavo Martín
Published: September 2023

BACKGROUND:

Bacillus Calmette–Guerin (BCG) is the standard adjuvant treatment for intermediate and high-risk non-muscle invasive bladder cancer (NMIBC) following transurethral resection of the bladder (TURB). However, the optimal dose, strain, and schedule of BCG remain unclear.

OBJECTIVE:

To evaluate the impact of BCG dose reduction on oncological outcomes and toxicity in patients with non-muscle invasive bladder cancer.

METHODS:

We performed a systematic review of the literature in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases. Selected studies were analyzed for Meta Analysis using PRISMA criteria. The study focused on disease recurrence, progression, and toxicity. We also compared the oncological outcomes of the different BCG strains.

RESULTS:

A total of 2963 patients in 13 randomized controlled trials were included. In recurrence analysis, we found a non-significant difference between the full dose and any dose reduction of BCG (RR = 1.17, [1.06–1.28], I2 = 0%, p = 0.7). In terms of progression, the difference was also non-statistically significant (RR: 1.12 [0.89 - 1.41], I2 = 0%, p = 0.93). In the toxicity analysis, there were more local (RR: 0.81 [0.67–0.99] I2 = 76%; p < 0.01) and systemic (RR: 0.53 [0.34–0.82] I2 = 83%; p < 0.01) side effects in the full dose group than in the dose reduction group. There were no statistically significant differences in oncological outcomes between the analyzed BCG strains.

CONCLUSIONS:

Dose reduction did not affect the oncological outcomes of patients with NMIBC who received adjuvant therapy with BCG. On the other hand, dose reduction showed a significant trend towards fewer systemic and local side effects. Further studies comparing oncological and toxicity outcomes using different strains are needed.
Intrusion detection using rough-fuzzy set and parallel quantum genetic algorithm
Authors: Ling Zhang , Qi Gui , Min Huang
Published: September 2023

An intrusion detection method using rough-fuzzy set and parallel quantum genetic algorithm (RFS-QGAID) is proposed in this paper. The RFS-QGAID is applied to solve the serious problems of determining the optimal antibodies subsets used to detect an anomaly. To obtain a simplified antibodies collection for high dimensional Log data sets, RFS is applied to delete the redundant antibody features and obtain the optimal antibodies features combination. Then, the optimal attitudes are entered into the QGA classifier for learning and training in the following stage. At last, the detected Log antigens are fed into RFS-QGAID, and we can classify the intrusion types. With RFS-QGAID, we give the simulations, the results on real Log data sets show that: the higher detection accuracy of RFS-QGAID is higher detection accuracy, but the false negative rate is lower for small samples sets, the adaptive performance is higher than other detection algorithms.
MODERN TECHNOLOGIES FOR THE FORMATION OF MARKETING MANAGEMENT STRATEGIES OF ENTERPRISES AS AN IMPERATIVE FOR THEIR INNOVATIVE DEVELOPMENT
Authors: Mudra Mariia , Jing Qian
Published: September 2023

The essence and features of the main modern strategies of marketing activity of enterprises are considered through the prism of the latest management trends. It is substantiated that the system of marketing strategic management of the enterprise is the basis of the efficiency of its activity, which affects competitiveness and determines the direction of further development. An analysis of the evolution of the species diversity of marketing tools was carried out. The stages of formation and development of the enterprise's marketing management strategy are revealed. It is noted that the use of marketing tools for the formation of the company's strategy increases the efficiency of management as a whole. The main elements of the marketing management system of the enterprise are studied. The need to introduce advanced, i.e. marketing-oriented, strategic enterprise management has been proven. The essence and general provisions of the evaluation of the effectiveness of the enterprise's marketing management strategy and directions for its improvement are substantiated. The essence and features of the main modern strategies of the marketing activity of enterprises are considered through the lens of the latest market trends. There are cases where enterprises succeed using modern marketing strategies to expand the horizons of their activities. Developed components of management of marketing tools, based on indicators of monitoring the existing level of satisfaction and loyalty of consumers due to mergers, acquisitions and innovations of new products by the main key players of the market. It is substantiated that the system of marketing strategic management of the enterprise is the basis of the efficiency of its activity, which affects competitiveness and determines the direction of further development in modern conditions.
ZONING CONFLICTS OF HISTORICAL AND ARCHITECTURAL NATURE IN THE CITY OF IVANO-FRANKIVSK IN THE PROCESS OF PUBLIC ADMINISTRATION
Authors: Stovban Vasyl
Published: September 2023

Existing spatial conflicts related to the historical environment of the city of Ivano-Frankivsk are analyzed. Examples of the emergence of conflict-forming factors of spatial conflicts related to the impact on the historical and architectural environment of our city are given. An analysis of the appearance of this kind of spatial conflicts, which have the greatest impact on the historical center of the city, where the historical environment of our city is most concentrated, was conducted.

Conducting an analysis of the given examples of spatial conflicts that arose on the territory of our city, related to the historical environment, gives grounds for drawing conclusions about the low professional ethics of architects, designers, managers who make decisions without thinking about the preservation of architectural monuments, are not far-sighted in terms of preserving the historical past. Manifestations of inconsistency between architectural and urban planning and historical and architectural legislation. After all, with further actions, we can lose the historical memory associated with many buildings or places, and in the future such places can be displayed only on commemorative plaques, and in the best case, or completely forgotten.

It is necessary to continue the work on conducting a total inventory of the architectural monuments of our city with subsequent subsequent certification of historical monuments. Conduct work with all owners or tenants on the conclusion of security agreements with memo holders.

Unsystematic intervention in the historical environment deprives us of many historical evidences; any construction work can be carried out in the historical area only after the conclusion of archaeologists. Therefore, during the constant monitoring of construction sites in the center of the city, the department for the protection of cultural heritage obliges developers to conclude agreements with archaeological services, or to assist archaeologists in surveying during earthworks, although in most cases they cause active opposition from both developers and builders.
ABOUT THE MODELING OF PUBLIC SAFETY CENTERS OF TERRITORIAL COMMUNITIES
Authors: Shulyk Vasyl , Koshel Vladislav
Published: September 2023

A significant theoretical and practical work in the study of issues, related to the modeling of the architectural environment, has been made by architectural scientists for today. The use of architectural environment modeling method, opens up an opportunity to simplify the process of developing models of one or another architectural environment as a system, and will also contribute to improving the process of formulating efficiency criteria.

Architectural systems, which differ in quantitative and qualitative characteristics of their components, can be represented by one formal model with accuracy up to C-isomorphism. Therefore, the structural model of the urban planning system "population - activity - environment" and the model of human life-activity processes (functional model) can be taken as a basis for building a model of public safety centers (PSC).

Public safety centers belong to the public service system and includes three services (law enforcement, medical and emergency services). Basing on this, it is possible to build a structural and functional model of the PSC organization, which includes all systemically determined components.

The constituent components of the specified PSC model should be as following: recreation, service, material production and communications. These subsystems should include the following structural components: "restoration" - population in need of restoration, population restoration activities (human recreation) and environment for restoration; "service" - service personnel, their activities and environment for service; "production" - production personnel, production activities and environments for production; "communications" - the personnel of communication networks, the service of communications and the environment for communications.

In general, the presentation of public safety centers in the form of a structural and functional model allows to do the research of them and formation based on a systematic approach.
Engineering and geological aspects in the museumification of architectural and archaeological monuments
Authors: Dubrovin K. A. , Vyazkova O. E.
Published: September 2023

Background. Tourism is an important economic sector, attracting a large amount of people to historical sites, including architectural and archaeological monuments. At present, the question of their museumification is resolved by considering their historical value and economic expediency. At the same time, the possibility of physically preserving the structures and materials of extant monuments is frequently ignored.

   Aim. To substantiate the need to study the engineering and geological conditions during museumification of architectural and archaeological monuments to predict their sustainable functioning.

   Materials and methods. The results of the authors’ long-term field and desktop research into the impact of engineering and geological conditions on the preservation of architectural and archaeological monuments during museumification were generalized and analyzed.

   Results. Two different scenarios were formulated for carrying out an engineering and geological assessment of the state of not only already museumified monuments, but also those that are supposed to be museumified in order to ensure their long-term, safe and manageable functioning as museums.

   Conclusion. The need to involve geologists in solving the question of museumification of architectural and archaeological monuments is substantiated. Examples of successful implementation of such a practice, which allowed emergency situations to be avoided, are provided.
Formation and placement of oil and gas traps within the junction area of Cis-Ural trough and West-Ural outer folding zone
Authors: Bondareva L. I. , Osipov A. V.
Published: September 2023

Background. The Cis-Ural trough and its junction area with the West-Ural outer folding zone are known as structures with high oil and gas potential. However, the complexity of the geological structure, due to the wide development of faults of various genesis and morphology, the discrepancy between the structural plans of parts of the sedimentary section, etc., as well as the low quality of the available seismic material and, as a result, unreliable geological models of the object are a deterrent to the development of the resource base of the area under consideration.

   Aim. To study the formation conditions and to typify oil and gas traps within the junction area of the Cis-Ural trough and the West-Ural outer folding zone.

   Materials and methods. A series of seismogeological profiles in the sublatitudinal direction was used for the research: No. 2622001-02 ShP in the interpretation of Drozdov V. V., Krasnovishersk-Severouralsk in the interpretation of Popov A. G., No. 15-RS in the interpretation of Makarevich V. N. The technique of structural-kinematic modeling was used, which allows reconstructing the structural evolution of fold-thrust zones.

   Results. Based on geological and geophysical data and using modern computer modeling technologies, a substantiated conceptual geological model of the formation and structure of the junction area of the Cis-Ural trough and the West-Ural outer folding zone was created. Oil and gas trapswere predicted and their types were determined.

   Conclusion. Conditions for the formation, preservation and placement of oil and gas traps within the junction area of the Cis-Ural trough and the West-Ural outer folding zone were studied. The types of the traps were determined, which, in conjunction with the analysis of hydrocarbon systems, creates the basis for a scientifically robust assessment of the prospects for oil and gas potential of the studied area.
Meteorological impact on gravimeter and seismometer readings
Authors: Antonov Yu. V. , Ponomarenko I. A.
Published: September 2023

Background. The density of atmospheric air varies with temperature. Therefore, variations in the atmospheric layer temperature leads the emergence of local gravity anomalies. The amplitude of such anomalies can exceed ±0.1 mGal. The results obtained by the Arti Geophysical Observatory(Yekaterinburg, Russia) on the non-tidal variations of gravity confirm the influence of temperature variations on gravimeter readings, which may significantly exceed the calculated data.

   Aim. To assess the impact of weather changes on seismic and gravity fields.Materials and methods. At the RAS Bishkek Geodynamic Test Area (Bishkek, Kyrgyzstan), RAS Institute of Geophysics (Yekaterinburg, Russia) and Zapolye Observatory (Vladimir, Russia), gravity was measured by CG-5 AUTOGRAV gravimeters. At the Shults Cape (Vladivostok, Russia), Arti (Yekaterinburg, Russia) and BFO (Black Forest, Germany [10]) observatories, gravimetric measurements were conducted by La Coste & Romberg tidal gravimeters.

   Results. Variations in the atmospheric layer temperature were found to lead to the emergence of local gravity anomalies. The amplitude of such anomalies can exceed ±0.1 mGal. The results obtained by the Arti Geophysical Observatory (Yekaterinburg, Russia) on the non-tidal variations of gravity confirm the influence of temperature on gravimeter readings, which may significantly exceed the calculated data.

   Conclusion. Meteorological processes, such as liquid-water content and the Earth’s atmospheric temperature, affect the readings of gravimeters and seismometers. The atmospheric air density varies with temperature. Along with temperature, gravimeters and seismometers are affected by pressure, humidity and water content of the atmosphere. This is related to atmospheric deformations under the influence of the Moon and the Sun. Meteor streams and their impact on the Earth’s atmosphere have the greatest influence on the readings of gravimeters and seismometers.
IMPLEMENTATION OF THE DIRECT METHOD OF TEACHING FOREIGN LANGUAGES IN FRENCH TEXTBOOKS USED IN GALICIA (THE FIRST HALF OF THE 20TH CENTURY)
Authors: Labinska B. , Ivashchuk А.
Published: September 2023

Abstract. The article under discussion deals with the analysis of French textbooks used at the lessons ofthe French language in Galicia in the first half of the twentieth century. The authors carry out an overview ofthe sources relevant to the issue under study and prove that the topic has never been an object of any scientificresearch before. In the article, we have reviewed five French textbooks and identified the main method of Frenchlanguage teaching implemented in them. The books, which were used, can be divided into three groups – textbooks,readers, and grammar reference books. All the textbooks under analysis were recommended by the educationauthority of Galicia. The textbooks are analyzed according to the criteria proposed by N. Borysko. Thus, the Frenchtextbooks used in Galicia are found to be compiled by means of the direct method of teaching foreign languagesthat is marked with a wide range of phonetic material, the absence of translation exercises, the emphasis ona practical approach to improving foreign language competencies.
French Grammar Course Syllabus for Bachelor Students
Authors: Rusnak D. , Matvieieva О.
Published: September 2023

Abstract. The syllabus is designed for bachelor students majoring in 014 Secondary Education,014.023 Secondary Education, Language and Literature (French). The obligatory course is aimed at developingstudents receptive and reproductive grammar skills, namely teach students to build simple and complexsentences of different types according to the French language, and also teach them to perceive and understanda foreign language by ear and while reading. The course consists of four modules: concordance of the times of the indicative mood, pronouns, types of conditional phrases and Subjunctive mood. The course focuseson teaching the understanding and use of grammatical structures in different communication situations.The Syllabus offers a list of references on the course topics.
Dialogical speech competence as a goal of prospective English teachers development
Authors: Koval S. V.
Published: September 2023

The article considers the essence and structure of competence in dialogical speechand the importance of its development in prospective English teachers. The research describesthe main componentsof the competence in the dialogical speech and highlights the importance of non-verbal component to the classicalstructure of competence in dialogical speech because of significant influence on the interaction. Purpose.To describe the essence and structure of dialogical speech competence. Methods. The following methods havebeen used in the research of the competence in dialogical speech as a goal of prospective English teachers’development: theoretical and empirical (critical analysis of pedagogical, psychological, linguistic, methodologicalliterature; comparative analysis of scientific, experimental research, domestic and foreign experience, whichdescribes methods the English competence in dialogical speech development in prospective teachers, the methodof pedagogical observation). Results. Teacher-student dialogue is the basis of communication and an effectivetool for teaching English, as it not only functions as a language exchange between teachers and students, butalso creates a community of speakers and listeners who purposefully use a foreign language. Competence indialogical speech is based on knowledge, skills and abilities and communicative ability, which determines thelevel of involvement of the subject in the dialogue. The research proposes the addition to the classical structureof the competence by the non-verbal component introduction. Traditionally, visual speech has been regardedas a redundant signal in verbal communication. But the article highlights that visual speech information playsa sufficient role in dialogical speech. Conclusion. To ensure a high level of English teachers training, we suggestto exploring the components of competence in English dialogical speech deeply, especially the stages of theirformation and ways of its development.
Noções Básicas Sôbre as Provas de Função Respiratória na Prática Médica
Authors: Viruez Fernando Monasterio
Published: September 2023

O autor explica a importância e os princípios técnicos da realização das provas funcionais respiratórias, analizando cada uma delas e assinala seu significado clínico na prática médica.
O Brasil Apresenta Teses Modernas e Objetivas Perante a 17ª Assembléia Mundial de Saúde
Authors: Fadul Wilson
Published: September 2023

Palavras do Ministro da Saúde WILSON FADUL, em Genebra, mostram a interligação entre conceitos de Saúde e Desenvolvimento Econômico.
Enzimologia Diagnóstica
Authors: Santos Cesar Lima
Published: September 2023

O Autor faz, inicialmente, uma síntese dos atuais conhecimentos sôbre a natureza química, origem e destinos biológicos das enzimas. Analisa os métodos de separação das iso-enzimas organo-específicas e suas pontencialidades na individualização diganóstica das agressões teciduais. Discute também os critérios de elegibilidade dos testes diagnósticos de enzimas. Aborda as enzimas digestivas, referindo a modificação introduzida pela adição de Pancreozimina ao clássico teste da Secretina e estuda as possibilidades da nova técnica no diagnóstico do Câncer de pâncreas e da pancreatite crônica. Refere também aos estudos sôbre a elevação do Tripsinogênio sérico naquelas doenças, assim como do Inibidor da quimotripsina na avaliação prévia à mastectomia radical, no Câncer de mama. Analisa o valor diagnóstico das enzimas metabólicas, baseando-se na correlação de um grupo de doenças com padrões de respostas fundamentais, dependentes do comportamento das Dehidrogenases Isocítrica e Lática. Focaliza os comportamentos enzimáticos mais importantes no Infarto do miocárdio, salientando os aspectos favoráveis do estudo da Dehidrogenase Hidroxibutírica. Apresenta, em apêndice, esquema das atividades da Transaminase Glutâmica Oxalacética e da Dehidrogenase Lática assim como outros exames laboratoriais no diagnóstico do Infarto pulmonar. Apresenta os aspectos de valor diagnóstico e prognóstico da Aldolase na Distrofia Muscular Progressiva. O Autor faz uma esquematização das atividades enzimáticas de maior valor semiológico em várias formas de Câncer. Refere os estudos realizados com a Fosfohexose Isomerase e a Aldolase na evolução dos Cânceres de mama e próstata. Faz referência particular ao trabalho de WETSTONE e cols., onde se demonstra a importância da Colinesterase no diagnóstico precoce das doenças cancerosas. O Autor apresenta um estudo crítico comparativo das atividades enzimáticas na hepatite a virus, na cirrose do tipo Laennec e sua utilização no discrimine diagnóstico das icterícias intra e post-hepáticas. Na parte final do trabalho são referidos os testes de valor diagnóstico nas disgenopatias vinculadas a perturbações primárias do controle enzimático. O Autor frisa a importância da determinação do “Número de Dibucaína”, teste que permite o rastreamento dos portadores de anomalias congênitas da Colinesterase. Como esta condição patológica não tem manifestações clínicas patentes, a exposição dos pacientes a inibidores da enzima provoca apnéia prolongada, usualmente mortal. Finalizando, o Autor advoga a inclusão do “Número de Dibucaína” como teste rotineiro quando da internação dos pacientes do LN.C., visando impedir as consequências catastróficas do uso inadvertido daqueles inibidores.
O Sistema T.N.M. de Classificação dos Tumores Malígnos: Instruções Para Sua Aplicação
Authors: União Internacional Contra o Câncer
Published: September 2023

Desde 1950 a U.I.C.C. tem dedicado particular interesse ao estudo da classificação dos tumores malignos por estádios clínicos. Deste problema se ocupou, em princípio, a Comissão de Nomenclatura e Estatística de Tumores, presidida pela Dra. Isabela H. Perry (1950-1954). A Comissão decidiu adotar como base de seu trabalho, sobre a classificação por estádios clínicos, as definições gerais de extensão local de tumores malignos propostas pela Subcomissão do O.M.S. de Registros e Apresentação Estatística de Casos de Câncer. Em julho de 1953, a Comissão de Nomenclatura e Estatística de Tumores realizou uma reunião em Copenhagne com o “Comitê de Agrupamento dos Estádios em Cancerologia e Apresentação de Resultados Terapêuticos do Câncer”, do Congresso Internacional de Radiologia. Assim, chegou-se a um acordo sobre esta técnica geral de classificação por estádios clínicos dos cânceres da mama, do colo uterino e do faringe. A Comissão convidou a U.I.C.C. a continuar este trabalho, visando a: a) chegar a outras conclusões sobre os cânceres da mama, do colo uterino e do laringe; b) externar a técnica geral aos cânceres de outras localizações. A U.I.C.C. aceitou a incumbência e sua comissão de investigação, em 1954, nomeou um grupo especial, presidido pelo Dr. P. Denoix para prosseguir as investigações. Entre 1954 e 1958 este grupo preparou propostas relativas aos princípios gerais que devem ser levados em conta para a classificação por estádios clínicos dos tumores malignos e sua aplicação, em particular, à mama e ao laringe. Estas propostas foram apresentadas aos especialistas de várias nações, a fim de que se obtivesse a opinião do maior número possível de técnicos.
Kualitas Keputusan Investasi, Risiko Bisnis, Efisiensi dan Pertumbuhan Laba
Authors: Hirawati Heni , Giovanni Axel , Sijabat Yacobo P
Published: September 2023

Penelitian ini bertujuan untuk memberikan bukti secara empiris mengenai peran kualitas keputusan investasi, risiko bisnis dan efisiensi terhadap pertumbuhan laba perusahaan. Kualitas keputusan investasi diproksikan dengan ROA (Return on Assets), risiko bisnis diproksikan dengan DAR (Debt to Assets Ratio), dan efisiensi diproksikan dengan ATR (Asset Turnover Ratio). Penelitian ini menggunakan data sekunder dengan format data panel. Populasi penelitian terdiri dari seluruh perusahaan yang tercatat dalam indeks SRI KE-HATI dari tahun 2017-2021. Penarikan sampel penelitian dilakukan dengan metode purposive sampling, dan diperoleh sampel penelitian sebanyak 15 perusahaan atau sebanyak 75 observasi. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi data panel dengan bantuan aplikasi STATA. Hasil uji F menunjukkan bahwa secara simultan variabel kualitas keputusan investasi, risiko bisnis, dan efisiensi berpengaruh terhadap pertumbuhan laba. Hasil pengolahan data menjelaskan bahwa variabel kualitas keputusan investasi, risiko bisnis, dan efisiensi secara parsial tidak berpengaruh terhadap pertumbuhan laba.
Analisis Break Even Point untuk Meningkatkan Tingkat Penjualan Rengginan Istimewa Cap Bawang di Kecamatan Pringsurat Kabupaten Temanggung
Authors: Winarsih Winarsih , Martono Sri
Published: September 2023

Penelitian ini bertujuan untuk mengetahui besarnya laba yang diperoleh, pengusaha terlebih dahulu harus mengetahui tingkat Break Even Point (BEP) yang dicapai yaitu keadaan dimana perusahaan tidak mengalami kerugian maupun keuntungan. Karena ingin mengetahui pada tingkat volume berapa, penjualan Rengginan Istimewa Cap Bawang mengalami Break Even Point. Jenis penelitian yang digunakan dalam penelitian ini yaitu penelitian deskripsi dengan pendekatan kuantitatif, sumber adta yang digunakan adalag data sekunder dengan Teknik pengumpulan data keuangan Rengginan Istimewa Cap Bawang di Kecamatan Pringsurat Kabupaten Magelang. Dari perhitungan diatas jumlah barang yang dijual periode Mei 2021 agar home industri Rengginan Cap Bawang mencapai Break Even Point adalah sebesar 19,46 unit atau saat melakukan penjualan sebesar Rp. 388.568,00. Jika melebihi Break Even Point berarti mengalami keuntungan tapi jika kurang dari Break Even Point maka akan mengalami kerugian. Margin Of Safety menunjukkan jarak antar penjualan yang direncanakan dengan penjualan pada Break Even Point. Dengan demikian Margin Of Safety juga menggambarkan batas jarak, dimana jika berkurangnya penjualan melampaui batas jarak tersebut perusahaan akan menderita kerugian. Semakin kecil Margin Of Safety berarti semakin cepat perusahaan menderita kerugian. Margin of Safety Mei 2021 yaitu 5,94% atau Rp. 56.430,00.
Pengaruh Expertise, Attractiveness, Trustworthiness, dan Review Quality Terhadap Purchase Intention Produk Kosmetik
Authors: Malikhah Feni Nafisatun , Susanti Dewi Noor
Published: September 2023

Purpose of this study was to determine the effect of expertise, attractiveness, trustworthiness, and review quality on purchase intention. The population in this study were all Putra Bangsa University students who had watched Rachel Goddard's Beauty Vlogger content. This study uses purposive sampling method with a sample of 100 respondents. Based on statistical methods, multiple linear regression tests were carried out, validity tests, reliability tests, classical assumption tests (multicollinearity test, heteroscedasticity test, and normality test), partial test, stimulus test and coefficient of determination test. Based on the results of the study, it can be seen that expertise has a simultaneous effect on purchase intention, attractiveness, trustworthiness, and review quality has a simultaneous effect on purchase intention of 35.7%. The results of this study indicate that based on the validity and reliability test all variables are declared valid and reliable. Based on the results of the t-test of expertise and trustworthiness, there is no significant effect on purchase intention, while attractiveness and review quality have a significant effect on purchase intention.
Pengaruh Religiusitas dan Etika Kerja Islam Terhadap Organizational Citizenship Behavior dengan Mediasi Kepuasan Kerja
Authors: Mustakhirah Nafisatul , Helmy Irfan
Published: September 2023

Penelitian ini bertujuan untuk menguji pengaruh religiusitas dan etika kerja islam terhadap organizational citizenship behavior melalui kepuasan kerja sebagai variabel mediasi. Metode pengambilan sampel yang digunakan adalah teknik non probability sampling yakni sampling jenuh yaitu mengambil sampel secara keseluruhan atau semua anggota populasi digunakan sebagai sampel. Responden pada penelitian ini adalah karyawan pada BMT SM NU Kramat Cabang Kebumen berjumlah 38 orang. Penelitian ini menggunakan metode analisis deskriptif dan statistik dilakukan uji validitas, uji relibilitas, uji multikolinearitas, uji heteroskedastisitas, uji normalitas, uji korelasi, koefisien determinasi, uji t, analisis jalur, dan perhitungan pengaruh. Pengujian dalam uji t menunjukan bahwa religiusitas berpengaruh positif terhadap kepuasan kerja pada BMT SM NU Kramat Cabang Kebumen. Etika kerja islam berpengaruh positif terhadap kepuasan kerja. Religiusitas  berpengaruh positif terhadap organizational citizenship behavior. Etika kerja islam berpengaruh positif terhadap organizational citizenhsip behavior. Religiusitas terhadap organizatonal citizenship behavior melalui kepuasan kerja BMT SM NU Kramat Cabang Kebumen kepuasan kerja dapat memediasi antara religiusitas dan organizational citizenship behavior. Etika kerja islam terhadap organizational citizenship behavior melalui kepuasan kerja BMT SM NU Kramat Cabang Kebumen, kepuasan kerja tidak dapat memediasi antara etika kerja islam dengan organizational citizenship behavior.
Pengaruh Intellectual Capital, Tax Avoidance dan Leverage Terhadap Nilai Perusahaan dengan Profitabilitas sebagai Variabel Intervening
Authors: Qurrotulaini Nihayatul , Anwar Saiful
Published: September 2023

Intellectual capital, tax avoidance and leverage toward the company value with profitability as the variable of Intervening. This research uses quantitative research method with the use of doubled linear regrecy analysis and route analysis as a method of data analysis. This research uses secondary data of data panel on manufacture food and beverages company during period of 2014-2019. The method of sample taking used is purposive sampling. The sample in this research is 10 companies. The result of research shows that partially, the independent variable does not affect on dependent variable with coeficient value bigger than significancy level. Meanwhile, for the variable of Intervening, the value of the Counted-T from Intellectual Capital and Tax Avoidance variables shows bigger number than the Table-T. Thus occured an indirect relation between intellectual capital dan tax avoidance variables towards company value.
Peningkatan Pendapatan Masyarakat Melalui Ekonomi Kreatif dan Kewirausahaan Sosial
Authors: Pambudi Agus Rilo , Rahardjo Budi
Published: September 2023

Permasalahan sosial merupakan fenomena yang kerap terjadi dimasyarakat. Permasalahan sosial dimasyarakat mulai dari kesejahteraan, kesehatan, pendidikan, pengangguran, kemiskinan  sampai dengan kerusakan lingkungan. Permasalahan tersebut disebabkan salah satunya karena askes masyarakat yang terbatas  dalam menjangkau dikarenakan pendapatan yang masih minim,tidak bisa dipungkiri juga bahwa untuk memperoleh akses atau menikmati hal diatas berupa kesehatan,pendidikan, kesejahteraan dan lainya masyarakat masih perlu mengeluarkan pendapat yang tergolong tidak sedikit. Mengatasi permasalahan tersebut ekonomi kreatif dapat menjadi solusi dalam hal meningkatkan pendapatan masyarakat melalui pemanfaatan sumber daya yang terbatas dikombinasikan dengan kreativitas dan inovasi untuk menghasilkan keuntungan. Disisi lain ada kewirausahaan sosial  yang juga dapat mengatasi permasalahan tersebut melalui penerapan aspek sosial dalam berwirausaha agar memberikan dampak positif. Melalui kewirausahaan sosial keuntungan yang diperoleh bisa didistribusikan kepada masyarakat sehingga pendapatan bisa meningkat. Metode penelitian menggunakan metode studi literatur untuk mencari hasil  dari penelitian terdahulu kemudian dianalisis lebih lanjut sebagai literatur atau jurnal untuk mendukung dan memperkuat peningkatan pendapatan masyarakat melalui ekonomi kreatif dan kewirausahaan sosial. Hasil penelitian menunjukan bahwa sektor ekonomi kreatif dapat meningkatkan pendapatan masyarakat begitu juga dengan kewirausahaan sosial dapat meningkatkan pendapatan masyarakat.
Pengaruh Kinerja Lingkungan, Kinerja Keuangan dan Ukuran Perusahaan Terhadap Environmental Disclosure pada Perusahaan Manufaktur yang Terdaftar di BEI Tahun 2016-2019
Authors: Assiva Rizki , Kaharti Eni
Published: September 2023

This Research was conducted to determine the effect of environmental performance, financial performance and firm size on environmental disclosure in manufacturing companies listed on the IDX in 2016-2019 with a total of 150 companies. By using the purposive sampling method, 25 manufacturing companies were taken. The analysis technique used is multiple linear regression analysis. The results of this research indicate that environmental performance have an effect on environmental disclosure, financial performance has a negative effect on environmental disclosure, firm size has no effect on environmental disclosure.
Pengaruh Social Media Influencer Terhadap Brand Image dan Attitude yang Berdampak pada Purchase Intention Skin Mobile Legends melalui Review di Youtube
Authors: Nurohman Fauzi , Riptiono Sulis
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Social Media Influencer terhadap Brand Image dan Attitude yang berdampak pada Purchase Intention skin Mobile Legends.  Metode pengambilan sampel yang digunakan dalam penelitian ini adalah nonprobability sampling dengan teknik purposive sampling. Total sampel yang akan digunakan dalam penelitian ini adalah 100 responden. Metode pengumpulan data menggunakan kuesioner. Analisis data yang digunakan yaitu uji instrument validitas dan reliabilitas, uji asumsi klasik dan uji hipotesis dengan menggunakan program SPSS 25.0 for windows. Hasil penelitian ini menunjukkan bahwa semua item pernyataan setiap variabel valid dan reliable. Model penelitian memenuhi kriteria uji asumsi klasik tidak terdapat multikolonieritas, heterokedastisitas, dan memenuhi asumsi normalitas. Berdasarkan hasil uji parsial (uji t) substrukural I diperoleh hasil bahwa variabel Social Media Influencer terhadap Brand Image berpengaruh secara signifikan terhadap Brand Image. Pada substruktural II diperoleh hasil bahwa variabel Social Media Influencer berpengaruh secara signifikan terhadap Attitude. Pada substruktural III diperoleh hasil bahwa variabel Brand Image dan Attitude berpengaruh secara signifikan terhadap Purchase Intention. Sedangkan variabel Social Media Influencer tidak berpengaruh secara signifikan terhadap Purchase Intention.
Pengaruh Kompensasi, Person Job Fit, dan Lingkungan Kerja Non Fisik Terhadap Kinerja Guru Tidak Tetap SMK Negeri Gombong Kebumen
Authors: Pratiwi Shelly , Helmy Irfan
Published: September 2023

Penelitian ini bertujuan untuk menganalisis pengaruh kompensasi, person job fit, dan lingkungan kerja non fisik terhadap kinerja guru. Penelitian ini mengambil sampel 38 guru SMK N 1 Gombong. Teknik sampel yang digunakan dalam penelitian ini adalah menggunakan metode sensus, dimana seluruh guru tidak tetap SMK N 1 Gombong  dijadikan sebagai sampel. Instrumen penelitian yang digunakan dalam penelitian ini adalah kuesioner untuk memperoleh data-data primer yang dibutuhkan. Analisis data menggunakan uji regresi linear berganda dengan alat bantu program SPSS versi 25. Hasil pengujian koefisien determinasi menunjukkan bahwa nilai Adjusted R2 sebesar 0,570 artinya 57% variabel kinerja dapat dipengaruhi oleh kompensasi, person job fit, dan lingkungan kerja non fisik dan 43% dipengaruhi oleh variabel lain di luar model. Berdasarkan hasil analisis regresi linier berganda dan uji t yang telah dilakukan dapat disimpulkan bahwa kinerja dipengaruhi oleh kompensasi, person job fit, dan lingkungan kerja non fisik.