bluuebunny/crossref_metadata_2025 huggingface dataset:
Physicochemical Characteristics and Anti-Bacterial Ability of Liquid Soap with the Addition of Pandan Wangi Extract
Authors:   University of Riau, Hamzah Farida Hanum , Putra Diswanto ,   University of Riau, Zalfiatri Yelmira ,   University of Riau, Pramana Angga ,   University of Riau
Published: September 2023

Pandan wangi leaves have bioactive properties that can inhibit the growth of Staphylococcus aureus and Escherichia coli bacteria so they can prevent skin infections. The ability of pandan wangi leaf extract to inhibit microbial growth can be applied to liquid soap. This research was conducted to determine the characteristics of liquid soap with the addition of pandan wangi leaf extract. This study used a completely randomized design with five treatments and three replications. The treatment in this study was a variation of adding pandan wangi leaf extract to the liquid. soap formulation, which were 1.5; 2.0; 2.5; 3.0; and 3.5 grams. The data obtained was analyzed statistically using analysis of variance (ANOVA). The results of variance showed that the addition of pandan wangi leaf extract had a significant effect on foam stability, acidity (pH), anti-bacterial activity test, and sensory test. The liquid soap treatment chosen in this study was the addition of 3.5 grams of pandan wangi extract with a foam stability value of 81.52%, specific gravity of 1.0596 g/ml, viscosity of 271.7 mPas, acidity of 9.02, amount of free alkali 0%, has an anti-bacterial inhibition zone against Escherichia coli 11.22 mm and Escherichia coli 12.22 mm, does not irritate, and is preferred by hedonic panelists with a description of pandan wangi aroma.
Dynamic Rheological, Thermal, and Structural Properties of Starch from Modified Cassava Flour (MOCAF) with Two Cultivars of Cassava
Authors:   Universitas Jember, Diniyah Nurud , Iguchi Miyuki ,   Prefectural University of Hiroshima, Nanto Mai ,   Prefectural University of Hiroshima, Yoshino Tomoyuki ,   Prefectural University of Hiroshima, Subagio Achmad ,   Universitas Jember
Published: September 2023

The objectives of this study were to investigate alteration in the starch properties of modified cassava flour from two different local cassava cultivars from Indonesia at different fermentation times, provide structural information for starch molecules, and characterize the dynamic rheological and thermal properties. Resistant starch, non-resistant starch, and total starch levels in the cassava cultivars were also evaluated. Changes in the starch properties of Cimanggu and Kaspro (local cultivars of cassavas from Indonesia) were compared following different fermentation times (0, 12, and 24 hours). The properties of starch from modified cassava flour were influenced by the fermentation time, although both cassava varieties showed the same general characteristics. Their levels of resistant starch, non-resistant starch, and total starch were 33.28% to 51.74%, 20.51% to 23.72%, and 53.81% to 72.25% (g/100 g dry sample), respectively. The starch granules for the non-fermented samples were oval, polygonal, and round shapes; however, during fermentation, the starch granules became more porous and developed cracks of various sizes. The starches of both varieties showed an onset temperature between 67.85 and 70.17 °C, a peak temperature of 69.33 °C to 71.62 °C, and an end set temperature of 68.62 °C to 70.95 °C, with enthalpy values ranging from 1.25 mJ/mg to 1.74 mJ/mg.
Pelemahan Masyarakat Sipil dan Gagalnya Desain Kelembagaan Demokrasi Pasca Reformasi 1998
Authors: Djo Damianus Benediktus Gene Djo , Jenila Patrisius Eduardus Kurniawan
Published: September 2023

The fall of Suharto did not make the position of civil society grow and had a significant impact on the trajectory of the consolidation of Indonesian democracy after the 1998 Reformation. Instead, in the sharing of the results, the picture is of a civil society that is much weaker and unable to support democratic agendas. The weakening of civil society after the 1998 reform was motivated by many factors, such as the tragedy of the 1965 massacre and the strengthening of the position of oligarchic groups in the post-1998 reform democratic system. Oligarchic networks are able to hijack democratic institutions through democratic means for the accumulation and protection of material resources. The operationalization of oligarchic networks in weakening the position of civil society manifests itself in repressive measures in a number of regulations that restrict the expression of freedom in the public sphere, such as the Law on Electronic Information and Transactions, which has so far often been usedas an instrument by public officials in silencing critics.In the midst of weakening and subordinating the position of civil society, it increasingly confirms that the institutional approach—an approach that is often used to measure the quality of democracy—is not enough to support the sustainability of an empowered and bargaining civil society in powerrelations. This is exactly where structural approaches come into play to address the impasse of democracy and the sustainability of civil society in post-1998 democratic politics. Through the use of qualitative approaches with descriptive analysis methods, this paper sees that the democratic agendas after the 1998 reform have not changed much towards improvement due to the weakening of the position of civil society.
Penetrasi Politik Identitas melalui Media Sosial: Studi Terbentuknya Identitas Politik “Kampret” dan “Cebong” di Indonesia
Authors: Ahmad Irfan Fauzi
Published: September 2023

This research discusses the emergence of cebong and kampret political identities and their penetration through social media from 2014 to 2022. Segmentation and doctrine of political groups in the 2014 Presidential Election (Pilpres) clashed where Joko Widodo supporters were labeled as cebong and Prabowo Subianto's supporters as kampret. This is qualitative research. Source of data taken through observation and literature study. The results of the study show that the penetration of cebong and kampret identity politics on social media was formed from clashes between the political elites of the PDI-P Party and the Gerindra Party. The process of defining identity antagonistically by defining who is friend and who is foe participates in strengthening identity which results in a “zero sum game” relationship between subjects. This process triggers the emergence of other definitions of identity such as the kampret label giving rise to the cebong label, the cebong label gives rise to the kadrun label and so on. The next stage of penetration is the emergence of the existence and influence of influencers on the cebong-kapret feud phenomenon. The existence of Ade Armando and Denny Siregar as supporters of Joko Widodo as well as the existence of the Opposite6890 account which created negative narratives against Jokowi's government strengthened this institutionalized polarization. This is also an attempt to impress the existence of enemies that hinder the search for power. The characteristics of social media that provide space for freedom of expression without space and time barriers make political expression negative. The emergence of this political identity group has been identified to trigger the development of blasphemy, hate speech, and hoaxes that have the potential to cause division and undermine the nationalism of Indonesian citizens.
Introduction: Life Writing through Refugee Tales
Authors: Mayer Sandra , Mieszkowski Sylvia , Potter Kevin
Published: September 2023

This cluster took off from an interdisciplinary and international workshop hosted at the University of Vienna in May 2022. Some of the original contributors turned their presentations into articles for this cluster; other articles were recruited later on. The original idea for both the workshop and cluster was inspired by the UK’s Refugee Tales project, founded and organized by David Herd and Anna Pincus. Some of the articles collected here discuss the life writing aspect of this project from different angles and positions: Patience Agbabi as contributing author to the first Refugee Tales volume, Sandra Mayer as a scholar of literary celebrity, and Sylvia Mieszkowski as cultural analyst. Other articles take a look at other projects in which displaced persons work on life narratives alongside citizens of the host countries: Jessica Gustafsson writes about the Swedish Flyktpodden podcast and Helga Ramsey-Kurz about the Austrian ARENA initiative. Two articles provide the collection with an opening frame, as they focus on the paradoxes that are perpetually produced by immigration law and the cultural conceptions of ‘the refugee’ in the European context (Judith Kohlenberger) and in Austria, specifically for minors (Ayşe Dursun and Birgit Sauer). An Afterword by one of the founders and organizers of Refugee Tales (David Herd) closes the cluster, offering an assessment of the project’s role in the context of the UK’s political situation in the summer of 2023, just after both Houses of Parliament passed the Illegal Migration Bill, which the UN has publicly denounced as contrary to international law.
The Refugee (Tale) Paradox: Narratives of Vulnerability and Aspirationality
Authors: Kohlenberger Judith
Published: September 2023

The global refugee regime can be characterized by central paradoxes, similarly to how our societal narratives around displacement and refuge are fundamentally contradictory, yet immanent to the system they help to maintain. Following Hannah Arendt’s notion of the ‘aporia of human rights’, I discuss one particular salient set of contradictions as the ‘refugee paradox’. It describes a set of policy expectations and narratives around the figure of the refugee as vulnerable and hence deserving of protection, yet self-sufficient and self-reliant; one who must be happy to have survived and not aspire to much more, but, once the asylum status is approved, must display agency and aspirations for upward mobility; a victim of their circumstances, yet a role model of integration and economic success in the host society. I analyse the discursive charging and real-life consequences of the refugee paradox with a particular view to discourses of ‘worthy’ and ‘unworthy’, or ‘deserving’ and ‘undeserving’ refugees in the present geopolitical landscape. Existing interventions, be they local aid, humanitarian intervention or political activism, necessarily move within the narrow confines of this paradox and therefore seldom accomplish more than symptom control. Thus, at its core, the refugee paradox is naturalized and serves to legitimate the status quo.
Afterword: The Refugee Tales Walking Inquiry into Immigration Detention
Authors: Herd David
Published: September 2023

The purpose of this afterword is to provide an update on the recent actions of the Refugee Tales project against the background of new developments in UK policies on asylum and immigration. The afterword reports on the parliamentary launch of the Refugee Tales Walking Inquiry into Immigration Detention. It then considers the implications of the UK government’s proposal to offshore asylum processing to Rwanda and, more broadly, of the new powers to detain and deport established by the Illegal Migration Bill. The afterword details the development, process, and findings of the Walking Inquiry and shows how those findings relate to and extend the remit of the official Public Inquiry into ‘the mistreatment of individuals who were detained at Brook House Immigration Removal Centre in 2017’. In conclusion, it comments on the importance of Refugee Tales’ practice of walking, as a process of collective action and deliberation, and as counter to the politics of hostility.
Methods for the Clinical Validation of Digital Endpoints: Protocol for a Scoping Review Abstract
Authors: Rego Sílvia , Henriques Ana Rita , Serra Sofia Silvério , Costa Teresa , Rodrigues Ana Maria , Nunes Francisco
Published: September 2023

Background

Clinical trials often use digital technologies to collect data continuously outside the clinic and use the derived digital endpoints as trial endpoints. Digital endpoints are also being developed to support diagnosis, monitoring, or therapeutic interventions in clinical care. However, clinical validation stands as a significant challenge, as there are no specific guidelines orienting the validation of digital endpoints.

Objective

This paper presents the protocol for a scoping review that aims to map the existing methods for the clinical validation of digital endpoints.

Methods

The scoping review will comprise searches from the electronic literature databases MEDLINE (PubMed), Scopus (including conference proceedings), Embase, IEEE (Institute of Electrical and Electronics Engineers) Xplore, ACM (Association for Computing Machinery) Digital Library, CENTRAL (Cochrane Central Register of Controlled Trials), Web of Science Core Collection (including conference proceedings), and Joanna Briggs Institute Database of Systematic Reviews and Implementation Reports. We will also include various sources of gray literature with search terms related to digital endpoints. The methodology will adhere to the Joanna Briggs Institute Scoping Review and the Guidance for Conducting Systematic Scoping Reviews.

Results

A search for reviews on the existing evidence related to this topic was conducted and has shown that no such review was previously undertaken. This review will provide a systematic assessment of the literature on methods for the clinical validation of digital endpoints and highlight any potential need for harmonization or reporting of methods. The results will include the methods for the clinical validation of digital endpoints according to device, digital endpoint, and clinical application goal of digital endpoints. The study started in January 2023 and is expected to end by December 2023, with results to be published in a peer-reviewed journal.

Conclusions

A scoping review of methodologies that validate digital endpoints is necessary. This review will be unique in its breadth since it will comprise digital endpoints collected from several devices and not focus on a specific disease area. The results of our work should help guide researchers in choosing validation methods, identify potential gaps in the literature, or inform the development of novel methods to optimize the clinical validation of digital endpoints. Resolving these gaps is the key to presenting evidence in a consistent way to regulators and other parties and obtaining regulatory acceptance of digital endpoints for patient benefit.

International Registered Report Identifier (IRRID)

PRR1-10.2196/47119
Health Providers’ Perceptions and Experiences of Using mHealth for Chronic Noncommunicable Diseases: Qualitative Systematic Review and Meta-Synthesis (Preprint)
Authors: Gu Yu , Guan Yushan , Meng Zhaolin
Published: September 2023

BACKGROUND

Mobile health (mHealth) technology has great potential for addressing the epidemic of chronic noncommunicable diseases (CNCDs) by assisting health providers (HPs) with managing these diseases. However, there is currently limited evidence regarding the acceptance of mHealth among HPs, which is a key prerequisite for harnessing this potential.

OBJECTIVE

This review aimed to investigate the perceptions and experiences of HPs regarding the barriers to and facilitators of mHealth use for CNCDs.

METHODS

A systematic search was conducted in MEDLINE (via Ovid), Embase, Web of Science, Google Scholar, and Cochrane Library (via Ovid) for studies that assessed the perceptions and experiences of HPs regarding the barriers to and facilitators of mHealth use for CNCDs. Qualitative studies and mixed methods studies involving qualitative methods published in English were included. Data synthesis and interpretation were performed using a thematic synthesis approach.

RESULTS

A total of 18,242 studies were identified, of which 24 (0.13%) met the inclusion criteria. Overall, 6 themes related to facilitators were identified, namely empowering patient self-management, increasing efficiency, improving access to care, increasing the quality of care, improving satisfaction, and improving the usability of the internet and mobile software. Furthermore, 8 themes related to barriers were identified, namely limitation due to digital literacy, personal habits, or health problems; concern about additional burden; uncertainty around the value of mHealth technology; fear of medicolegal risks; lack of comfortable design and experience; lack of resources and incentives; lack of policy guidance and regulation; and worrisome side effects resulting from the use of mHealth.

CONCLUSIONS

This study contributes to the understanding of the beneficial factors of and obstacles to mHealth adoption by HPs for CNCDs. The findings of this study may provide significant insights for health care workers and policy makers who seek ways to improve the adoption of mHealth by HPs for CNCDs.
Chest X-Ray–Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study (Preprint)
Authors: Gómez-Valverde Juan J , Sánchez-Jacob Ramón , Ribó José Luis , Schaaf H Simon , García Delgado Lara , Hernanz-Lobo Alicia , Capellán-Martín Daniel , Lancharro Ángel , Augusto Orvalho , García-Basteiro Alberto L , Santiago-García Begoña , López-Varela Elisa , Ledesma-Carbayo María J
Published: September 2023

BACKGROUND

Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnostic tests, underscores the need for improved tools to enhance diagnosis and care in resource-limited settings.

OBJECTIVE

This study aims to present a telemedicine web platform, BITScreen PTB (Biomedical Image Technologies Screen for Pediatric Tuberculosis), aimed at improving the evaluation of pulmonary TB in children based on digital chest x-ray (CXR) imaging and clinical information in resource-limited settings.

METHODS

The platform was evaluated by 3 independent expert readers through a retrospective assessment of a data set with 218 imaging examinations of children under 3 years of age, selected from a previous study performed in Mozambique. The key aspects assessed were the usability through a standardized questionnaire, the time needed to complete the assessment through the platform, the performance of the readers to identify TB cases based on the CXR, the association between the TB features identified in the CXRs and the initial diagnostic classification, and the interreader agreement of the global assessment and the radiological findings.

RESULTS

The platform’s usability and user satisfaction were evaluated using a questionnaire, which received an average rating of 4.4 (SD 0.59) out of 5. The average examination completion time ranged from 35 to 110 seconds. In addition, the study on CXR showed low sensitivity (16.3%-28.2%) but high specificity (91.1%-98.2%) in the assessment of the consensus case definition of pediatric TB using the platform. The CXR finding having a stronger association with the initial diagnostic classification was air space opacification (χ21>20.38, P<.001). The study found varying levels of interreader agreement, with moderate/substantial agreement for air space opacification (κ=0.54-0.67) and pleural effusion (κ=0.43-0.72).

CONCLUSIONS

Our findings support the promising role of telemedicine platforms such as BITScreen PTB in enhancing pediatric TB diagnosis access, particularly in resource-limited settings. Additionally, these platforms could facilitate the multireader and systematic assessment of CXR in pediatric TB clinical studies.
Perceptions of ecological momentary assessment impact on trial participants’ smoking behavior: A qualitative analysis of a pilot study (Preprint)
Authors: Stevens Elizabeth R , Li Rina , Xiang Grace , Wisniewski Rachel , Rojas Sidney , O'Connor Katherine , Wilker Olivia , Vojjala Mahathi , El-Shahawy Omar , Sherman Scott E
Published: September 2023

BACKGROUND

Ecological momentary assessment (EMA) is an increasingly used tool for data collection in behavioral research. There has been limited evaluation of EMA’s potential influence on behavior.

OBJECTIVE

This paper examines perceptions of the potential behavioral influence of EMA on research participants enrolled in a tobacco treatment intervention.

METHODS

We performed a qualitative analysis of in-depth interviews with participants enrolled in a tobacco treatment intervention pilot randomized clinical trial that used text messaging to collect EMA data on smoking behaviors. Participants were prompted to share their experiences with the EMA texting component of the trial, but were not directly asked about the influence of the EMA on their behavior. Transcripts were coded according to the principles of the Framework analysis for applied research. The codes were then examined, summarized, and grouped together into themes using the principles of grounded theory.

RESULTS

Themes developed from the analysis suggest there is a potential for EMA, in the form of a text-messaging smoking diary, to influence participant smoking behaviors. EMA prompts’ impact was not uniform across participants with some perceiving it as a source of accountability, while others reported the messages serve as trigger for cigarette use.

CONCLUSIONS

The collection of EMA smoking behavior data via text messaging may influence behaviors and perceptions of participants in tobacco treatment interventions. More research is needed to determine the magnitude of impact and mechanisms to account for the potential effects of EMA. A broader discussion of unintended effects introduced by the use of EMA is warranted among the research community.

CLINICALTRIAL

N/A
Effect of Prosocial Behaviors on e-Consultations in a Web-Based Health Care Community: Panel Data Analysis (Preprint)
Authors: Liu Xiaoxiao , Guo Huijing , Wang Le , Hu Mingye , Wei Yichan , Liu Fei , Wang Xifu
Published: September 2023

BACKGROUND

Patients using web-based health care communities for e-consultation services have the option to choose their service providers from an extensive digital market. To stand out in this crowded field, doctors in web-based health care communities often engage in prosocial behaviors, such as proactive and reactive actions, to attract more users. However, the effect of these behaviors on the volume of e-consultations remains unclear and warrants further exploration.

OBJECTIVE

This study investigates the impact of various prosocial behaviors on doctors’ e-consultation volume in web-based health care communities and the moderating effects of doctors’ digital and offline reputations.

METHODS

A panel data set containing information on 2880 doctors over a 22-month period was obtained from one of the largest web-based health care communities in China. Data analysis was conducted using a 2-way fixed effects model with robust clustered SEs. A series of robustness checks were also performed, including alternative measurements of independent variables and estimation methods.

RESULTS

Results indicated that both types of doctors’ prosocial behaviors, namely, proactive and reactive actions, positively impacted their e-consultation volume. In terms of the moderating effects of external reputation, doctors’ offline professional titles were found to negatively moderate the relationship between their proactive behaviors and their e-consultation volume. However, these titles did not significantly affect the relationship between doctors’ reactive behaviors and their e-consultation volume (P=.45). Additionally, doctors’ digital recommendations from patients negatively moderated both the relationship between doctors’ proactive behaviors and e-consultation volume and the relationship between doctors’ reactive behaviors and e-consultation volume.

CONCLUSIONS

Drawing upon functional motives theory and social exchange theory, this study categorizes doctors’ prosocial behaviors into proactive and reactive actions. It provides empirical evidence that prosocial behaviors can lead to an increase in e-consultation volume. This study also illuminates the moderating roles doctors’ digital and offline reputations play in the relationships between prosocial behaviors and e-consultation volume.
Evaluation of a New Telemedicine System for Early Detection of Cardiac Instability in Patients With Chronic Heart Failure: Real-Life Out-of-Hospital Study (Preprint)
Authors: Urien Jean Marie , Berthelot Emmanuelle , Raphael Pierre , Moine Thomas , Lopes Marie Emilie , Assayag Patrick , Jourdain Patrick
Published: September 2023

BACKGROUND

For a decade, despite results from many studies, telemedicine systems have suffered from a lack of recommendations for chronic heart failure (CHF) care because of variable study results. Another limitation is the hospital-based architecture of most telemedicine systems. Some systems use an algorithm based on daily weight, transcutaneous oxygen measurement, and heart rate to detect and treat acute heart failure (AHF) in patients with CHF as early on as possible.

OBJECTIVE

The aim of this study is to determine the efficacy of a telemonitoring system in detecting clinical destabilization in real-life settings (out-of-hospital management) without generating too many false positive alerts.

METHODS

All patients self-monitoring at home using the system after a congestive AHF event treated at a cardiology clinic in France between March 2020 and March 2021 with at least 75% compliance on daily measurements were included retrospectively. New-onset AHF was defined by the presence of at least 1 of the following criteria: transcutaneous oxygen saturation loss, defined as a transcutaneous oxygen measurement under 90%; rise of cardiac frequency above 110 beats per minute; weight gain of at least 2 kg; and symptoms of congestive AHF, described over the phone. An AHF alert was generated when the criteria reached our definition of new-onset acute congestive heart failure (HF).

RESULTS

A total of 111 consecutive patients (n=70 men) with a median age of 76.60 (IQR 69.5-83.4) years receiving the telemonitoring system were included. Thirty-nine patients (35.1%) reached the HF warning level, and 28 patients (25%) had confirmed HF destabilization during follow-up. No patient had AHF without being detected by the telemonitoring system. Among incorrect AHF alerts (n=11), 5 patients (45%) had taken inaccurate measurements, 3 patients (27%) had supraventricular arrhythmia, 1 patient (9%) had a pulmonary bacterial infection, and 1 patient (9%) contracted COVID-19. A weight gain of at least 2 kg within 4 days was significantly associated with a correct AHF alert (P=.004), and a heart rate of more than 110 beats per minute was more significantly associated with an incorrect AHF alert (P=.007).

CONCLUSIONS

This single-center study highlighted the efficacy of the telemedicine system in detecting and quickly treating cardiac instability complicating the course of CHF by detecting new-onset AHF as well as supraventricular arrhythmia, thus helping cardiologists provide better follow-up to ambulatory patients.
Pemanfaatan Silika Gel 70-230 Mesh Bekas Sebagai Pengganti Fase Diam Kromatografi Kolom pada Praktikum Kimia Organik
Authors: Emilda Emilda , Delfira Noviza
Published: September 2023

Salah satu modul percobaan dalam Praktikum Kimia Organik di laboratorium kimia organik jurusan kimia FMIPA-UNRI adalah kromatografi, yaitu kromatografi kolom yang menggunakan silika gel 70-230 mesh sebagai fase diam. Namun setelah selesai pengggunaan, silika gel 70-230 mesh menjadi limbah yang di buang begitu saja. Sedangkan harga dari silika gel 70-230 mesh cukup mahal. Oleh karena itu dilakukan penelitian tentang pemanfaatan silika gel 70-230 mesh bekas sebagai pengganti fase diam kromatografi kolom pada praktikum kimia organik. Penelitian dilakukan dengan cara mencuci silika gel bekas menggunakan larutan 40 mL bayclin yang di encerkan dalam 500 mL akuades, selanjutnya pencucian dilakukan secara bertahap dengan akuades dan metanol teknis, kemudian dikeringkan dengan menggunakan oven pada suhu 105 ᵒC selama 2 jam. Silika gel kotor dicuci sebanyak 200 gram dan didapatkan 194,212 gram silika gel bersih berwarna putih. Uji terhadap kemampuan silika gel setelah dicuci dalam memisahkan komponen yang terdapat pada campuran ekstrak metanol ubi jalar ungu (Ipomoea batatas) dan ekstrak metanol daun pucuk merah (Syzygium oleana), dibandingkan dengan silika gel baru. Hasil uji menunjukkan 4 pita serapan pada silika gel setelah dicuci, dan 4 pita serapan pada silika gel baru, yang ditandai dengan terbentuk 4 warna yang berbeda pada silika gel di tabung kolom dan pada vial penampung baik untuk ekstrak metanol ubi ungu maupun ekstrak metanol daun pucuk merah. Hal ini menunjukkan bahwa silika gel yang dicuci dengan bayclin mempunyai kemampuan memisahkan senyawa yang terdapat pada ekstrak metanol ubi ungu dan ekstrak metanol daun pucuk merah. Berdasarkan hasil penelitian tersebut silika gel yang telah dicuci selanjutnya dapat digunakan untuk kebutuhan praktikum kimia organik II khususnya di laboratorium kimia organik FMIPA Universitas Riau.
Pengaruh Ekstrak Daun Ipomoea batatas L. sebagai Flokulan Fe dalam Pengolahan Air
Authors: Rohana Hana , Maemunah Iin , Sonjaya Yaya
Published: September 2023

Kandungan besi (Fe) merupakan masalah yang sering ditemukan pada air tanah. Hal tersebut menyebabkan air berubah warna kekuningan dan berbau. Untuk menjernihkan serta mengurangi kandungan besi dalam air perlu adanya pengolahan air. Penelitian ini untuk mengetahui pengaruh ekstrak daun Ipomoea batatas L. sebagai flokulan terhadap kandungan besi dalam pengolahan air. Penelitian dilakukan melalui dua tahap. Tahap pertama yaitu optimasi parameter-parameter optimum pengolahan dilanjutkan dengan pengolahan air menggunakan parameter-parameter optimum dengan metoda Jar test. Tahap kedua yaitu analisis kadar besi pada air hasil olahan dan non olahan dengan metoda AAS, dan analisis gugus fungsi pada daun Ipomoea batatas L. secara FTIR. Hasil analisis menunjukkan parameter optimum pengolahan air menggunakan ekstrak daun Ipomoea batatas L. sebagai flokulan adalah pH 8, dosis koagulan 50 mg/L, dosis flokulan 25 mg/L, kecepatan pengadukan koagulan 200 rpm dan kecepatan pengadukan flokulan 40 rpm masing-masing selama 10 menit. Hasil pengujian kadar besi pada air non olahan 5,13 mg/L dan pada air olahan tidak terdeteksi. Uji statistik menunjukkan perbedaan signifikan antara konsentrasi besi di dalam air sumur sebelum dan sesudah diberi perlakuan. Perlakuan memberikan pengaruh berupa penurunan kandungan besi dalam air sumur. Hasil analisis gugus fungsi pada daun Ipomoea batatas L. mengandung -OH (3363), C=O karbonil (1653), dan C=C aromatik (1546). Simpulan hasil penelitian ini adalah ekstrak daun Ipomoea batatas L. berpengaruh pada penurunan kadar besi dalam air yang diduga karena mekanisme destabilisasi koloid jenis sweep floc melalui absorpsi kimia serta reaksi besi dengan flokulan yang mengandung gugus fungsi karboksilat dan fenolik.
CLOZAPINE INDUCED EXTRAPYRAMIDAL SYMPTOMS FOLLOWING ALCOHOL CONSUMPTION IN PATIENT WITH SCHIZOPHRENIA AND ALCOHOL DEPENDENCE SYNDROME: A CASE REPORT OF SIALORRHEA, ACUTE AKATHISIA AND DYSTONIA
Authors: AKHIL ARUN
Published: September 2023

Clozapine (CLZ), a second-generation or atypical antipsychotic, although not recommended as the first-line drug of choice in the treatment of schizophrenia and schizoaffective disorders; however, it is recommended in the treatment of Treatment-Resistant Schizophrenia and in schizophrenic patients to decrease the recurrent risk of suicidal behavior. For the cytochrome P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4, CLZ serves as a substrate. CLZ also exhibits drug-food interaction with alcohol leading to an increase in the risk of seizures and extrapyramidal symptoms. A case of a 36-year-old male patient with a known history of paranoid schizophrenia and alcohol dependence syndrome came with complaints of dystonia and hypersalivation 1 day following the consumption of alcohol after ingestion of tablet CLZ. After clinical pharmacist intervention, the doses were titrated and the patient improved gradually. With this, it can be postulated that the concomitant use of alcohol with CLZ can be a predisposing factor for drug toxicity in the patients and hence patients should be monitored and counseled to abstain from the use of alcohol while on CLZ therapy.
MATERNAL OBESITY AS A PREDICTIVE MARKER FOR ADVERSE PREGNANCY OUTCOME: A CASE–CONTROL STUDY
Authors: JYOTI SAINI  , SAWAI SINGH LORA  , MONICA CHETANI GUPTA
Published: September 2023

Objective: Obesity in pregnancy is an important risk factor for adverse maternal and neonatal outcomes. In the past, various studies have compared adverse pregnancy-related outcomes between obese and normal body mass index (BMI) mothers. In the present study, we aimed to examine the impact of obesity class on maternal and perinatal outcomes. The aim of the study was to evaluate the association between maternal adiposity and pregnancy outcomes.
 Methods: A prospective and cross-sectional study conducted at Zanana Hospital SMS Medical College Jaipur on 68 antenatal obese/overweight woman (BMI>25 kg/m2) and 68 control antenatal woman (BMI<25 kg/m2) with singleton pregnancies.
Results: The incidence of gestational diabetes was 8.82% and 2.94%, respectively, in obese and control group. The incidence of pre-eclampsia was 14.70% and 5.88% in obese and control group. The incidence of gestational hypertension was 8.82% and 5.88% in obese and control group. The cesarean delivery rates were higher in obese group (55.88%) than control group (32.35%). About 20.58% of babies born to obese women and 8.82% of babies born to control were admitted in NICU (p<0.05). The incidence of pre-term delivery, fetal abnormality, and macrosomia was higher in obese group as compared to control group.
Conclusions: Obesity increases the risk of many adverse maternal and neonatal outcomes. Therefore, appropriate measures must be taken to reduce obesity incidence in women of reproductive age to circumvent the adverse maternal and neonatal outcomes associated with obesity.
VOLTAIRE-RA and VOLTAIRE-RA extension: Clinical equivalence studies of BI 695501 (Cyltezo®; adalimumab-adbm) and adalimumab reference product in rheumatoid arthritis
Authors: Cohen Stanley
Published: September 2023

This video discusses the clinical equivalence of BI 695501 (Cyltezo®; adalimumab-adbm) and adalimumab for rheumatoid arthritis - the VOLTAIRE-RA and extension studies.
The Role of Accounting Conceptual Framework in Neoliberalism
Authors: Nugraha Farhani Kautsar , Sasongko Ananta Wahyu , Saputri Rizka Dibi Arryanti
Published: September 2023

Purpose: This article discusses the relationship between accounting regulations and neoliberalism. It will also discuss changes to the conceptual framework developed by the two financial accounting standard boards, namely the IASB and FASB. Methodology/approach: This article uses a conceptual review paper methodology on accounting theories and existing research to analyzes the conceptual framework developed by the IASB and FASB. Findings: The conceptual framework developed by the IASB and FASB plays a role in the survival of neoliberalism and the financialization of the capital market Practical implications: This article presents a thorough overview of the primary concerns associated with accounting conceptual framework and contributes to the ongoing discussion on standard setting. Originality/value: This paper offers an understanding of the key aspects of the accounting conceptual framework that are closely related to neoliberalism.
Corporate Social Responsibility (CSR) Disclosures, Board Of Directors And Company Profitability: Audit Quality As Moderation
Authors: Wicaksono Agung Prasetyo Nugroho , Wahyuningtias Adhinni Lailiya , Amalia Firda Ayu , Dewananda Wiharta
Published: September 2023

Purpose: This study aims to examine the effect of corporate social responsibility (CSR) and the board of directors on the company's profitability with audit quality as moderating variable. Methodology/approach: The population in this study are manufacturing compannies sub-sectors of food and beverage listed on the Indonesia Stock Exchange (IDX) in 2019 – 2021. The sampling method uses purposive sampling with a total sample were 56. The data analysis method used data panel analysis and moderated regression analysis. Findings: The result of this study shows that corporate social responsibility (CSR) has a significant effect on the company's profitability which was proxied by ROA, while the board of directors has no significant effect on the company's profitability which was proxied by ROA, and audit quality cannot affect the relationship between corporate social responsibility (CSR) and the company's profitability which was proxied by ROA, but audit quality can affect the relationship between the board of directors and the company's profitability which was proxied by ROA. Practical implications: This shows that in making a decision, audit quality is very important because high audit quality will strengthen decision-making carried out by the board of directors. With the high quality of the audit, the board of directors will be assisted in making decisions to obtain favorable results for the company and to increase the company's profitability Originality/value: The more CSR that is carried out by a company, the higher the ROA obtained, so the productivity of assets in obtaining net profit is getting better. The better a company is at obtaining net income, the greater the attractiveness of investors to the company because the rate of return will be greater.
Evaluation of Newly Synthesized Compounds Targeting Carbonic Anhydrase Enzyme for Antineoplastic Activity in Solid Tumors
Authors: Naji Esraa M. , Hussein Sahar A. , Naser Noor H.
Published: September 2023

Objective: This study was conducted with the aim of assessing the antineoplastic potential of recently developed compounds, namely F3, F4, and F5. These compounds were designed to target the carbonic anhydrase enzyme in solid tumors.

Methods: The synthesis of these compounds involved the utilization of sulfanilamide, chloroacetylchloride, thiourea, benzyl chloride derivatives, and silver nitrate. Docking studies were carried out using the MOE software program version 2015.10, and the cytotoxic activity was predicted through the implementation of the MTT assay.

Results: The compounds that were synthesized displayed noteworthy antineoplastic activity, as evidenced by both in silico simulations and cell line investigations. Notably, Compound F5 exhibited an IC50 value of 9.02 μg/ml for MCF7 cells, signifying a substantial difference when compared to the IC50 value of cisplatin. Moreover, Compounds F3 and F4 exhibited higher S scores in the docking study compared to acetazolamide, implying a more robust binding affinity to the catalytic site of the receptor. The inclusion of a substituted thiazole ring contributed to increased flexibility and enhanced receptor interaction.

Conclusion: The synthetic compounds put forth in this study demonstrated notable antineoplastic properties. Furthermore, the complexation process notably augmented the inhibition of cancer cell growth, underscoring their potential as promising agents for combating cancer.
Connective Tissue Mobilization Vs. Combination of Taping with Pelvic Tilt on Primary Dysmenorrhea.
Authors: Muthulakshmi K. , Monesh D. , Moses Srilakshmi , Aunselvi J. , Ebenezer Cyrus Bernard , Gunasekar Thirulogachandar , V.S. Rakshana.
Published: September 2023

Primary dysmenorrhea is pain aggravation on menstruation without any pelvic disease. It is perhaps the most widely recognizedissue females face, influencing them physically and mentally. Connective tissue mobilization can help venous return by increasing theproduction of prostaglandin and different substances and preventing their collection in the pelvis, which can be powerful during the period,to reduce the pain aggravation and inconvenience. This study examines the effects of connective tissue mobilization vs. a combination oftaping and pelvic tilt on unmarried women with primary dysmenorrhea. This is an experimental design with pre and post-comparativestudy. This was conducted in the physiotherapy outpatient department at ACS Medical College and Hospital. The study duration was about3 months. The subjects aged 18 to 25 years female with primary dysmenorrheal were included in this study. The subject with Pelvicinflammatory disease, Uterine/ovarian tumor, Spinal pathology, deformity, and PCOD, were excluded from this study. 30 subjects wereselected and divided into 2 groups in which Group-A 15 received connective tissue mobilization for 3-4 minutes with a total of 20minutes/day a day before menstruation for 3 days for consecutive 3 months, and Group B received taping with pelvic tilt was given 4 daysfor lower abdomen and lumbar, one day before menstruation taping was applied and pelvic tilt was given 2-3 minutes for 20 minutes/dayfor 3 consecutive months The outcome measures were a pain. The outcome tools were the Menstrual symptom questionnaire, Numericalrating scale, and WaLIDD score. Comparing the pretest and posttest within Group A and Group B, Group B shows a highly significantdifference in Mean values at P <_0.001. Thus this study concludes that a combination of taping and pelvic tilt reduces pain in unmarriedwomen having primary Dysmenorrhea.
PEMBERITAAN TRAGEDI KANJURUHAN DALAM TAYANGAN YOUTUBE NARASI MATA NAJWA: ANALISIS WACANA KRITIS VAN DIJK
Authors: Nur Ellya Fasilatul , Yarno Yarno , Fatin Idhoofiyatul
Published: September 2023

Pada tanggal 1 Oktober 2022, terjadi kekacauan pasca pertandingan sepak bola Liga 1 antara Arema FC melawan Persebaya di Stadion Kanjuruhan Malang yang menimbulkan korban sebanyak 712 orang. Kejadian tersebut menjadi perhatian berbagai pihak luput dari seorang jurnalis Najwa Shihab yang mengangkat topik tragedi Kanjuruhan dalam acara rutinnya yaitu Mata Najwa. Penelitian ini bertujuan untuk menganalisis struktur teks, kognisi sosial, dan konteks sosial dalam tayangan Mata Najwa epsiode tragedi Kanjuruhan. Penelitian ini termasuk penelitian deskriptif kualitatif menggunakan video Youtube sebagai data sember dan teknik pengumpulan data yang digunakan adalah dokumentasi, simak, dan catat. Teknik analisis data meliputi reduksi data, penyajian data, dan simpulan.Hasil penelitian yang ditemukan dalam tayangan Mata Najwa episode tragedi Kanjuruhan analisis wacana kritis Van Dijk yaitu berdasarkan dimensi teks ditemukan elemen-elemen struktur mikro menunjukkan permasalahan utama yaitu kronologi kejadian tragedi Kanjuruhan. Adapun analisis kognisi sosial menghasilkan skema yang paling dominan yaitu skema peristiwa. Terdapat dua wcana yang ditekankan dalam kognisi sosial yaitu pembenaran terkait gas air mata dan kericuhan terjadi akibat suporter turun ke lapangan. Penelitian ini berimplikasi dalam konteks sosial dapat membantu mengidentifikasi ketidakadilan yang terkandung dalam bahasa dan wacana yang digunakan oleh kelompok yang berkuasa.
PENGEMBANGAN RIKSABASA: APLIKASI PEMERIKSAAN KESALAHAN BERBAHASA INDONESIA
Authors: Primandhika Restu Bias , Yani Aurelia Sakti , Putri Adinda Insani , Farras Salman Khairy
Published: September 2023

Kurangnya pemahaman terhadap Pedoman Umum Ejaan Bahasa Indonesia (PUEBI) berdampak pada banyaknya kesalahan kebahasaan. Salah satunya dalam konteks penulisan mulai dari ejaan hingga ke tanda baca. Tidak hanya pada tulisan ilmiah yang ditulis oleh mahasiswa, guru, dosen tetapi juga acapkali ditemui dalam surat-surat resmi yang ditulis oleh sebuah instansi baik itu pemerintahan maupun swasta. Berdasarkan permasalahan tersebut, maka penelitian ini bertujuan untuk mengkaji aplikasi kebahasaan yang ada dan mengembangkan aplikasi pemeriksa kebahasaan Riksabasa. Studi pendahuluan terbatas dilakukan terlebih dahulu untuk mengetahui dominasi kesalahan berbahasa dari berbagai tataran linguistik. Pengembangan aplikasi dilakukan melalui aplikasi prototyping seperti Adobe XD dan pengembangan melalui android studio.Diharapkan penelitian pengembangan ini dapat menghasilkan satu aplikasi yang dapat menjadi alternatif khususnya dalam menulis tugas akhir, makalah, esai, dan artikel.
Modernisasi Pemikiran Maulana Syaikh Zainudin Abdul Madjid Dalam Pengembangan Ajaran Islam Pada Suku Sasak
Authors: Ajjahidi Muhammad Hilmi
Published: September 2023

Abstrak: Penelitian ini membahas tentang modernisasi pemikiran maulana Syaikh Zainudin Abdul Madjid dalam pengembangan ajaran islam pada suku sasak. Dalam mengkaji pemikiran Maulana Syaikh Zainuddin Abdul Madjid penelitian ini menggunakan jenis penelitian dengan menggunakan pendekatan kualitatif, dan merupakan penelitian kepustakaan atau library research. Adapun mengenai teknik analisis data dilakukan dengan metode pengumpulan (data collection), reduksi data (data reduction), penyajian data (data display), dan penarikan kesimpulan serta verifikasi (conclusion drawing or verivication). Penelitian ini menghasilkan kesimpulan bahwa Kehidupan manusia tidak akan pernah terlepas dari permasalahan pembaharuan, hal tersebut dikarenakan semakin maju dan pesatnya perkembangan zaman yang ada. Dalam hal ini Maulana Syaikh Zainuddin selaku ulama’ dan juga tokoh karismatik melakukan pembaharuan ajaran Islam dalam beberapa aspek dalam kehidupan masyarakat. Pembaharuan dilakukan dalam beberapa aspek yang menurut Maulana Syaikh Zainuddin sangat penting di antara dalam hal pendidikan, sosial dan dakwah. Berubahnya sistem pendidikan menuju yang lebih modern dengan menganut sistem formal agar pendidikan lebih terarah sesuai dengan perkembangan zaman, dalam hal sosial organisasi kemasyarakatan didirikan sebagai bentuk wadah bernaungnya pendidikan tersebut dan dakwah dilakukan dengan sistem lebih modern.
Kata Kunci: Modernisasi; Pemikiran; Ajaran Islam.
Seq2Sat & SatAnalyzer toolkit: towards comprehensive microsatellite genotyping from sequencing data
Authors: Liu Peng , Wilson Paul , Redquest Bridget , Keobouasone Sonesinh , Manseau Micheline
Published: September 2023

Accurate and efficient genotyping of microsatellite loci is essential
for their application in population genetics and various demographic
analysis. Protocols for next generation sequencing of microsatellite
loci generate high-throughput and cross-compatible allele scoring
characteristics: common issues associated with size separation on
conventional capillary-based protocols. As a result, we have developed a
novel, ultra-fast, all-in-one software Seq2Sat in C++ to support
accurate automated microsatellite genotyping. It directly takes raw
reads of microsatellite amplicons and subsequently performs read quality
control before inferring genotypes based on depth of read, sequence
composition and length. It does not produce any intermediate files,
making I/O very efficient. Additionally, we developed a module in
Seq2Sat for sex identification based on sex locus amplicons. We further
developed a user-friendly website-based platform SatAnalyzer to conduct
reads-to-report analyses by calling Seq2Sat to generate genotype tables
and interactive genotype graphs for manual editing. SatAnalyzer also
allows visualization of read quality and distribution across loci and
samples to troubleshoot multiplex optimization and high-quality library
preparation. To evaluate its performance, we benchmarked SatAnalyzer
against conventional capillary gel electrophoresis and an existing
microsatellite genotyping software MEGASAT. Results show that
SatAnalyzer can achieve > 0.993 genotyping accuracy and
Seq2Sat is ~ 5 times faster than MEGASAT despite many
more informative tables and figures generated. Seq2Sat and SatAnalyzer
are freely available at github
(https://github.com/ecogenomicscanada/Seq2Sat) and dockerhub
(https://hub.docker.com/r/rocpengliu/satanalyzer).