bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of perioperative clinical hypnosis on heart rate variability in patients undergoing oncologic surgery: secondary outcomes of a randomized controlled trial
Authors: Azam Muhammad Abid , Weinrib Aliza Z. , Slepian P. Maxwell , Rosenbloom Brittany N. , Waisman Anna , Clarke Hance , Katz Joel
Published: March 2024

Introduction

Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome study, it was hypothesized that surgical oncology patients randomized to receive perioperative clinical hypnosis (CH) would demonstrate greater heart-rate variability (HRV) during rest and relaxation at a 1-month post-surgery assessment compared to a treatment-as-usual group (TAU).

Methods

After REB approval, trial registration and informed consent, 92 participants were randomized to receive CH (n = 45) or TAU (n = 47). CH participants received a CH session before surgery and during post-surgical in-hospital stay HRV was assessed during rest (5 min) and relaxation (10 min) before and 1-month after surgery. Pain intensity was obtained using a 0–10 numeric rating scale pre and post 1-week and 1-month post surgery.

Results

One month after surgery, HRV was significantly higher in CH group (n = 29) during rest and relaxation (both p < 0.05, d = 0.73) than TAU group (n = 28). By contrast, rest and relaxation HRV decreased from pre- to 1-month post-surgery for the TAU (both p < 0.001, d > 0.48) but not the CH group. Pain intensity increased from pre-surgery to 1-week post-surgery (p < 0.001, d = 0.50), and decreased from 1-week to 1-month post-surgery (p = 0.005, d = 0.21) for all participants.

Discussion

The results suggest that hypnosis prevents the deleterious effects of surgery on HRV by preserving pre-operative vagal activity. These findings underscore the potential of clinical hypnosis in mitigating the adverse effects of surgery on autonomic function and may have significant implications for enhancing post-surgical recovery and pain management strategies.

Clinical Trial Registration

ClinicalTrials.gov, identifier (NCT03730350).
Can we achieve pain stratification in musculoskeletal conditions? Implications for clinical practice
Authors: Sofat Nidhi , Lambarth Andrew
Published: March 2024

In the last few years there has been an increased appreciation that pain perception in rheumatic and musculoskeletal diseases (RMDs) has several mechanisms which include nociceptive, inflammatory, nociplastic and neuropathic components. Studies in specific patient groups have also demonstrated that the pain experienced by people with specific diagnoses can present with distinctive components over time. For example, the pain observed in rheumatoid arthritis has been widely accepted to be caused by the activation of nociceptors, potentiated by the release of inflammatory mediators, including prostaglandins, leukotrienes and cytokine networks in the joint environment. However, people with RA may also experience nociplastic and neuropathic pain components, particularly when treatments with disease modifying anti-rheumatic drugs (DMARDs) have been implemented and are insufficient to control pain symptoms. In other RMDs, the concept of pain sensitisation or nociplastic pain in driving ongoing pain symptoms e.g. osteoarthritis and fibromyalgia, is becoming increasingly recognised. In this review, we explore the hypothesis that pain has distinct modalities based on clinical, pathophysiological, imaging and genetic factors. The concept of pain stratification in RMD is explored and implications for future management are also discussed.
Characteristics of adolescents referred for bariatric surgery in Abu Dhabi, United Arab Emirates
Authors: Beck Reem Hassan , Afrooz Imrana , Suhail Masalawala Muhammad , Watad Rama , Al Shaban Talat , Deeb Asma
Published: March 2024

About a third of children and adolescents are overweight or obese in the United Arab Emirates, and referrals for metabolic and bariatric surgery (MBS) are now common. Despite excellent evidence that MBS should be considered in adolescents with severe obesity, it remains a management approach of last resort in many cases. Baseline, real-world data on adolescent patients living with obesity referred for surgery, their characteristics, and how these relate to current and future referral policy are important to ensure best practice. Here we examined the demographic, anthropometric, and clinical characteristics of adolescents referred for MBS over a three-year period to Sheikh Shakhbout Medical City (SSMC), Abu Dhabi, UAE. Ninety-two adolescents living with obesity were recruited: 54.3% were female, the average age was 16.3 ± 2.4 years, and 88.0% of patients had a first-degree relative with a history of obesity and 62% a family history of bariatric surgery. The average BMI was 47.7 ± 10.5, and the average percentage of the 95th percentile BMI was 169.5 ± 38.8%. Complications of obesity (hypertension, type 2 diabetes and prediabetes, dyslipidemia, and liver function abnormalities) were common. Our analysis highlights that there exists a mismatch between the profiles of patients referred for MBS, local guidelines, and international best practice in decision-making for referral to MBS services. While many adolescents in the UAE seem to enjoy family support and experience in the surgical management of obesity, local guidelines need updating to reflect changes in the definitions of obesity, thresholds for referral, and to remove unnecessary developmental stage barriers to increase the window for personalized surgical management.
Experience in the treatment of long-gap esophageal atresia by intraluminal esophageal stretching elongation
Authors: Zhang Ning , Wu Wenjie , Zhuang Yujia , Wang Weipeng , Pan Weihua , Wang Jun
Published: March 2024

Objective

To summarize the experience with intraluminal esophageal stretching elongation (ILESE) in the successful treatment of long-gap esophageal atresia (LGEA) at a single center.

Methods

Clinical data of 68 neonates who underwent LGEA between February 2015 and January 2022 were retrospectively analyzed. Four patients died of multiple associated severe malformations and did not undergo ILESE. Esophageal anastomosis was successfully performed in 60 cases (93.75%) and failed in 4 cases (6.25%) treated with ILESE. The ILESE techniques, esophageal reconstruction, results, postoperative complications, and follow-up treatment were analyzed.

Results

The beginning time of performing ILESE preoperation was 53.4 ± 39.4 days after birth, and the age of esophageal reconstruction was 122.2 ± 70.3 days after birth in 60 cases. The gap length of proximal and distal esophageal segments which were evaluated the first time at admission was 4.8 ± 1.3 vertebral bodies, whereas the gap before anastomosis was −0.46 ± 0.90 vertebral bodies. Among the patients with esophageal primary-anastomosis, 55 received thoracoscopic surgery, and 5 underwent thoracotomy in the early stage. Of the 60 children with ILESE, 58 underwent end-to-end esophagostomy, of which 17 cases were combined with circular esophagotomy (livaditis), and 2 cases of esophageal lengthening were combined with the reversal of the ligulate loop of the proximal esophagus (flap). Overall, 59 cases were cured (98.3%), and 1 patient died of respiratory failure postoperatively. All patients were followed up for 7–96 months. Postoperative anastomotic leakage occurred in 16 patients (27.6%), all of whom were successfully treated conservatively. Anastomotic stenosis occurred in 49 cases (83.1%), all of which were successfully managed by non-surgical treatment, including 12.7 ± 9.3 times of esophageal balloon dilatation and 2 cases of stent dilatation. Gastroesophageal reflux occurred in 44 patients (74.6%), including associated or acquired esophageal hiatal hernia in 22 patients, and Nissen fundoplication was performed in 17 patients.

Conclusions

ILESE is an effective method for prolonging the proximal and distal esophagus of the LGEA to reconstruct esophageal continuity using its esophageal tissue, with an efficacy rate of 93.75%. Postoperative anastomotic stricture and gastroesophageal reflux are common and require long-term, standardized follow-up and treatment.
Case report: Successful induction of buprenorphine in medically complex patients concurrently on opioids: a case series at a tertiary care center
Authors: Shelton Thomas , Nama Sharanya , Hall Orman , Williams Margaret
Published: March 2024

Effective pain management is essential for optimal surgical outcomes; however, it can be challenging in patients with a history of opioid use disorder (OUD). Buprenorphine, a partial opioid agonist, is a valuable treatment option for patients with OUD. Initiating buprenorphine treatment in patients concurrently taking opioids can be complex due to potential adverse outcomes like precipitated withdrawal. Evolving guidelines suggest there are benefits to continuing buprenorphine for surgical patients throughout the perioperative period, however situations do arise when buprenorphine has been discontinued. Typically, in this scenario patients would be restarted on buprenorphine after they have fully recovered from post-surgical pain and no longer require opioids for pain control. Unfortunately, holding MOUD may expose the patient to risks such as opioid induced respiratory depression or addiction relapse. In this case series, we discuss a novel method to restart buprenorphine in small incremental doses, known as micro-dosing, while the patient is still taking opioids for pain. We will present two complex clinical cases when this method was used successfully at a tertiary care hospital system.
Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review
Authors: Zhao Zhe , Lu Ming , Ying Yingqiu
Published: March 2024

Minocycline is a tetracycline commonly used for several dermatological diseases. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but severe adverse event which can be caused by minocycline. An 18-year-old male patient developed fever, acute rash, pharyngeal pain, lymphadenopathy, hematologic abnormalities, increased creatinine level, elevated liver enzyme levels, and splenomegaly 4 weeks after the oral treatment of minocycline, 100 mg daily, for acne. Once diagnosed with DRESS syndrome, intravenous methylprednisolone was applied and his clinical manifestations and laboratory results remarkably improved. Then, a total of 13 DRESS syndrome cases induced by minocycline were reviewed and their clinical characteristics were summarized. In these cases, only two patient (15.4%) was present with pharynx involved. In conclusion, we reported a rare minocycline-induced DRESS syndrome who developed fever, eosinophilia, acute rash, pharyngitis, lymphadenopathy, acute kidney injury, hepatitis, and splenomegaly. Our report provides detailed clinical features of minocycline-induced DRESS syndrome, which helps us further understand this severe adverse event.
Real-world effectiveness of GLP-1 receptor agonist-based treatment strategies on “time in range” in patients with type 2 diabetes
Authors: Chen Yongru , Chen Jingxian , Zhang Shuo , Zhu Dan , Deng Feiying , Zuo Rui , Hu Yufei , Zhao Yue , Duan Yale , Lin Benwei , Chen Fengwu , Liang Yun , Zheng Jiaxiong , Khan Barkat Ali , Hou Kaijian
Published: March 2024

Background: Diabetes affects millions of people worldwide annually, and several methods, including medications, are used for its management; glucagon-like peptide-1 receptor agonists (GLP-1RAs) are one such class of medications. The efficacy and safety of GLP-1RAs in treating type 2 diabetes mellitus (T2DM) have been assessed and have been shown to significantly improve time in range (TIR) in several clinical trials. However, presently, there is a lack of real-world evidence on the efficacy of GLP-1RAs in improving TIR. To address this, we investigated the effect of GLP-1RA-based treatment strategies on TIR among patients with T2DM in real-world clinical practice.

Methods: This multicenter, retrospective, real-world study included patients with T2DM who had previously used a continuous glucose monitoring (CGM) system and received treatment with GLP-1RAs or oral antidiabetic drugs (OADs). Patients who received OADs served as controls and were matched in a 1:1 ratio to their GLP-1RA counterparts by propensity score matching. The primary endpoint was the TIR after 3–6 months of treatment.

Results: According to propensity score matching, 202 patients were equally divided between the GLP-1RA and OAD groups. After 3–6 months of treatment, the TIR values for the GLP-1RA and OAD groups were 76.0% and 65.7%, respectively (p < 0.001). The GLP-1RA group displayed significantly lower time above range (TAR) and mean glucose values than the OAD group (p < 0.001). Subgroup analysis revealed that, compared with the administration of liraglutide, the administration of semaglutide and polyethylene glycol loxenatide (PEG-Loxe) significantly improved TIR over 3–6 months of treatment (p < 0.05).

Conclusion: These real-world findings indicate that GLP-1RA-based treatment strategies could be superior to oral treatment strategies for improving TIR among patients with T2DM and that once-weekly GLP-1RA may be more effective than a once-daily GLP-1RA.

Clinical trial registration:http://www.chinadrugtrials.org.cn/index.html, identifier number ChiCTR2300073697.
Ambient temperature regulates root circumnutation in rice through the ethylene pathway: transcriptome analysis reveals key genes involved
Authors: Cai Zeping , Dai Yinuo , Jin Xia , Xu Hui , Huang Zhen , Xie Zhenyu , Yu Xudong , Luo Jiajia
Published: March 2024

Plant roots are constantly prepared to adjust their growth trajectories to avoid unfavorable environments, and their ability to reorient is particularly crucial for survival. Under laboratory conditions, this continuous reorientation of the root tip is manifested as coiling or waving, which we refer to as root circumnutation. However, the effect of ambient temperature (AT) on root circumnutation remains unexplored. In this study, rice seedlings were employed to assess the impact of varying ATs on root circumnutation. The role of ethylene in mediating root circumnutation under elevated AT was examined using the ethylene biosynthesis inhibitor aminooxyacetic acid (AOA) and the ethylene perception antagonist silver thiosulfate (STS). Furthermore, transcriptome sequencing, weighted gene co-expression network analysis, and real-time quantitative PCR were utilized to analyze gene expressions in rice root tips under four distinct treatments: 25°C, 35°C, 35°C+STS, and 35°C+AOA. As a result, genes associated with ethylene synthesis and signaling (OsACOs and OsERFs), auxin synthesis and transport (OsYUCCA6, OsABCB15, and OsNPFs), cell elongation (OsEXPAs, OsXTHs, OsEGL1, and OsEXORDIUMs), as well as the inhibition of root curling (OsRMC) were identified. Notably, the expression levels of these genes increased with rising temperatures above 25°C. This study is the first to demonstrate that elevated AT can induce root circumnutation in rice via the ethylene pathway and proposes a potential molecular model through the identification of key genes. These findings offer valuable insights into the growth regulation mechanism of plant roots under elevated AT conditions.
Proton relaxometry of tree leaves at hypogeomagnetic fields
Authors: Fabricant Anne M. , Put Piotr , Barskiy Danila A.
Published: March 2024

We report on a cross-species proton-relaxometry study in ex vivo tree leaves using nuclear magnetic resonance (NMR) at 7µT. Apart from the intrinsic interest of probing nuclear-spin relaxation in biological tissues at magnetic fields below Earth field, our setup enables comparative analysis of plant water dynamics without the use of expensive commercial spectrometers. In this work, we focus on leaves from common Eurasian evergreen and deciduous tree families: Pinaceae (pine, spruce), Taxaceae (yew), Betulaceae (hazel), Prunus (cherry), and Fagaceae (beech, oak). Using a nondestructive protocol, we measure their effective proton T2 relaxation times as well as track the evolution of water content associated with leaf dehydration. Newly developed “gradiometric quadrature” detection and data-processing techniques are applied in order to increase the signal-to-noise ratio (SNR) of the relatively weak measured signals. We find that while measured relaxation times do not vary significantly among tree genera, they tend to increase as leaves dehydrate. Such experimental modalities may have particular relevance for future drought-stress research in ecology, agriculture, and space exploration.
Factors influencing older adults’ acceptance of voice assistants
Authors: Cao Xiancai , Zhang Hao , Zhou Bolin , Wang Dahua , Cui Chenhong , Bai Xuejun
Published: March 2024

Introduction

Voice assistants (VAs) have the potential to uphold and enhance the quality of life for older adults. However, the extent to which older adults accept and benefit from VAs may be relatively modest.

Methods

This study developed a comprehensive model combined with product and personal characteristics to explain the acceptance of VAs among older adults, using semi-structured interviews (Study 1) and questionnaires (Study 2).

Results

Results revealed that in terms of product characteristics, perceived usefulness and perceived enjoyment significantly affect behavior intention. Regarding personal characteristics of older adults, technological self-efficacy and dispositional resistance to change significantly affect behavior intention. However, no direct impact of perceived ease of use and perceived trust on behavior intention. Additionally, perceived enjoyment influenced both perceived ease of use and perceived usefulness.

Discussion

Results suggested the significant role of technology self-efficacy and dispositional resistance to change in predicting the acceptance of VAs among older adults. Our newly developed model offers valuable insights for tailoring VAs to this demographic during design and implementation.
Psychosocial strain and coping of Finnish working mothers during the COVID-19 lockdown: a job demand-control approach
Authors: Panula Venla , Lyyra Nelli , Kallitsoglou Angeliki , Acquah Emmanuel , Topalli Pamela-Zoe
Published: March 2024

Introduction

In March 2020 many countries around the world, including Finland, implemented lockdown measures to mitigate the unprecedented impacts of the coronavirus infectious disease (COVID-19) on public health. As a result, school and daycare settings closed indefinitely and working from home became the new normal for a big part of the workforce, which came with increased homeschooling and childcare responsibility for mothers.

Methods

In this article we present the findings from maternal responses to open ended questions on psychosocial well-being, and experiences of combining work, family life and homeschooling during the COVID-19 national lockdown in Finland in March–May 2020. Working mothers’ responses (n = 72) were analyzed through the lens of Karasek’s job demand-control model, focusing on how the mothers experienced the demands of their life during the lockdown, and how they saw their possibilities to control the situation.

Results

The findings indicated important variation in the level of experienced demand and control and associated compensatory factors during the COVID-19 lockdown across different subgroups of working mothers.

Discussion

The findings have implications for understanding strain and plausible supports among working mothers during the COVID-19 lockdown as well as in the face of acute adversity including the next possible public health crisis.
School-based promotion of physical literacy: a scoping review
Authors: Grauduszus Martin , Koch Lennart , Wessely Stefanie , Joisten Christine
Published: March 2024

Introduction

The role of physical activity in children’s healthy development is undisputed, with school-based interventions being seen as a priority. The promotion of physical literacy (PL) seems to be promising due to its holistic approach, combining physical, cognitive, and affective domains. To develop recommendations for possible measures, we compiled existing literature on existing school-based PL interventions.

Methods

Five databases (MEDLINE, Web of Science, SPORTDiscus, ERIC, and PsycInfo) were searched between July 6 and July 10, 2023, by combining the terms “physical literacy,” “school,” “program,” “workshop,” “intervention,” and “curriculum” as well as a manual search. Records were screened in a two-stage process by two independent authors using a priori criteria. Eligible studies concerned PL interventions in the school context. The included records were sorted according to school type/population, structure, content, PL domains addressed, and evaluation.

Results

In total, 706 articles were found through the database search and an additional 28 articles through the manual search. After removing duplicates, 502 publications remained, which were screened by title and abstract, leaving 82 full texts. These were cut down to 37 articles describing 31 different programs (19 in primary schools, eight in secondary schools, one in both primary and secondary schools, and three unspecified). Most interventions were conducted during physical education classes (n = 12). All three PL domains were addressed by five interventions, while 11 interventions solely concerned the physical domain. In addition, 21 interventions evaluated their effects on PL. Most evaluations showed small to moderate but inconsistent effects on several PL-related constructs (e.g., self-efficacy, motivation, movement skills). Interventions incorporating all three domains reported positive effects on physical competence and enjoyment.

Discussion

Although there is a growing body of data related to school-based PL promotion, their effects and practical application remains relatively underdeveloped: study designs, study quality, PL assessments, and results are heterogeneous. Corresponding research adhering to the holistic approach of PL will be crucial in clarifying the potential lifelong role of PL in promoting physical activity, increasing health and well-being and to actually enable development of recommendations for action.
The association between use of social media and the development of body dysmorphic disorder and attitudes toward cosmetic surgeries: a national survey
Authors: Ateq Khadijah , Alhajji Mohammed , Alhusseini Noara
Published: March 2024

Introduction

Body dysmorphic disorder (BDD) causes distress due to one's negative appraisal of their body image. The development of BDD has been linked to the passive use of social media and photo-editing apps. People with BDD typically pursue cosmetic surgeries to remedy their perceived flaws. The dramatic increase in the use of photo-editing apps and their well-established effects on mental health is a public health concern.

Purpose

To study the association between use of social media and the development of BDD and acceptance toward cosmetic surgeries (ACSS) among Saudis.

Methods

An online, cross-sectional, validated survey conducted among Saudis 18 and older. Descriptive analyses were utilized for demographics and prevalence rates of main study variables. ANOVA was used to compare mean scores in BDD and ACSS among different demographic groups. Tukeys post-hoc test was done to identify the categories that were different when the ANOVA test showed a statistically significance. A p-value of <0.05 was considered statistically significant.

Results

A total of 1,483 Saudi adults completed the questionnaire. Key results showed that BDD was found in 24.4 % of the sample. The percentage of participants with BDD who spent 4–7 h per day on Instagram and Snapchat (29%) was significantly higher than those who spent only less than an hour per day on these platforms (19%) (p < 0.001). Individuals with BDD had a significantly higher risk of accepting cosmetic surgery compared to those without BDD (p < 0.001).

Conclusion

A growing body of evidence suggests that social media may impact mental health in different ways. This study reveals that heavy use of these platforms is associated with negative appraisals about one's physical appearance, and it fosters one's tendency toward cosmetic surgery, especially among females.
Factors influencing public participation behavior relating to government microblogs on COVID-19 updates
Authors: Shao Peng , Li Menglei
Published: March 2024

Introduction

During the global COVID-19 pandemic, densely populated megacities engaged in active international exchanges have faced the most severe impacts from both the disease and the associated infodemic. This study examines the factors influencing public participation behavior on government microblogs in these megacities during the pandemic. It guides megacities in disseminating epidemic information, promoting knowledge on epidemic prevention, managing public opinion, and addressing related matters.

Methods

Utilizing the elaboration likelihood model’s central and peripheral routes, drawing on an empirical analysis of 6,677 epidemic-related microblogs from seven Chinese megacities, this study analyses the influence mechanisms influencing public participation behavior and reveals the regulatory role of confirmed case numbers. Meanwhile,a qualitative comparative analysis examines and discusses diferent confgurations of ixn fuential factors.

Results

The study reveals that microblog content richness demonstrates a U-shaped impact on public participation behavior. Conversely, content interaction, content length, and the number of fans positively impact participation, while update frequency has a negative impact. Additionally, the number of new confrmed cases positively regulates the impact of microblog content and publisher characteristics on public participation behavior. Public participation behavior also varies based on publishing time and content semantic features. This study further revealed the different confgurations of influential factors by QCA method.

Conclusion

This study reveals the impact mechanism of the microblog content and publisher characteristics on public participation behavior. It also demonstrates the regulatory role of newly confrmed cases in the way content and publishers’ characteristics influence public participation behavior. This study is of great significance for the operation of government microblogs, the release of emergency information, and the promotion of public participation.
Unraveling the link: environmental tobacco smoke exposure and its impact on infertility among American women (18–50 years)
Authors: Peng Liang , Luo Xiaohan , Cao Baodi , Wang Xiaohui
Published: March 2024

Purpose

The detrimental effects of environmental tobacco smoke (ETS) on women’s reproductive health have been widely recognized. However, the detailed association between exposure to environmental tobacco smoke and the incidence of infertility remains under-explored. This investigation focuses on exploring this potential connection.

Methods

For this analysis, we extracted data from the US National Health and Nutrition Examination Survey (NHANES) database, covering the years 2013 to 2018, focusing on individuals with recorded serum cotinine levels and infertility information. ETS exposure and fertility status were analyzed as independent and dependent variables, respectively. We applied weighted multivariate logistic regression method to evaluate the impact of ETS on infertility, including subgroup analyses for more detailed insights.

Results

The study encompassed 3,343 participants. Logistic regression analysis revealed a notable positive correlation between ETS exposure and infertility, with an odds ratio (OR) of 1.64 (95% Confidence Interval [CI]: 1.14–2.36). We observed a non-linear relationship between ETS exposure and infertility risk. Notably, infertility risk increased by 64% in serum cotinine levels above 0.136 compared to that in serum cotinine levels below 0.011. Further, subgroup analysis and interaction tests showed consistent results across different segments, underscoring the robustness of the ETS-infertility link.

Conclusion

Our findings suggest that environmental tobacco smoke exposure may be a contributing factor to infertility. These results reinforce the recommendation for women in their reproductive years to avoid ETS exposure, especially when planning for pregnancy.
Automated extraction of standardized antibiotic resistance and prescription data from laboratory information systems and electronic health records: a narrative review
Authors: Cappello Alice , Murgia Ylenia , Giacobbe Daniele Roberto , Mora Sara , Gazzarata Roberta , Rosso Nicola , Giacomini Mauro , Bassetti Matteo
Published: March 2024

Antimicrobial resistance in bacteria has been associated with significant morbidity and mortality in hospitalized patients. In the era of big data and of the consequent frequent need for large study populations, manual collection of data for research studies on antimicrobial resistance and antibiotic use has become extremely time-consuming and sometimes impossible to be accomplished by overwhelmed healthcare personnel. In this review, we discuss relevant concepts pertaining to the automated extraction of antibiotic resistance and antibiotic prescription data from laboratory information systems and electronic health records to be used in clinical studies, starting from the currently available literature on the topic. Leveraging automatic extraction and standardization of antimicrobial resistance and antibiotic prescription data is an tremendous opportunity to improve the care of future patients with severe infections caused by multidrug-resistant organisms, and should not be missed.
Investigation of maternal breastfeeding guarantee policy needs and influencing factors: a cross-sectional study in China
Authors: Li Junying , Zhang Lan , Guo Nafei , Liu Ying , Jiang Hui
Published: March 2024

Background

The promotion of breastfeeding is an important strategy to prevent neonatal death and improve maternal and infant health. But Chinese efforts to improve breastfeeding practices have not been particularly effective. There is still a long way to go to achieve the national health development goals. We aimed to explore the maternal demand for breastfeeding guarantee policy in China and to determine the impact of a range of socio-demographic and neonatal-related variables on breastfeeding guarantee policy demand.

Methods

The study was carried out in the Obstetrics and Gynecology hospital of Shanghai, one of China's earliest provincial and municipal maternal and child health care institutions. From June to November 2021, 1,292 women were recruited for the cross-sectional study in child health clinic. We collected relevant socio- demographic and neonatal-related data. Maternal breastfeeding needs were measured through a self-designed questionnaire on breastfeeding guarantee policy demands of mothers.

Results

The mean score of breastfeeding guarantee policy demand was 4.42 ± 0.51. There were statistically significant differences in the effects of maternal age, education level, family income per capita (Yuan), medical payment type, baby age, work status, and current feeding methods on the demand for breastfeeding guarantee policies (P < 0.05). Multiple linear regression analyses showed that higher education level (B = 4.437, P < 0.001), baby age (B = 2.150, P = 0.002), and current feeding methods (B = 2.754, P = 0.005) were significantly associated with a higher demand for a breastfeeding guarantee policy, the effect of medical payment type is the most influencing factor (B = −7.369, P < 0.001).

Conclusions

The maternal needs for breastfeeding guarantee policy are multi-faceted and urgent. In the process of improving and implementing policies, the government and relevant departments should take into account the actual needs of women who have different education levels, baby ages, family economics, and feeding methods.
From bare life and necropolitics to a feminist care ethic: ageism in the COVID-19 pandemic and future directions
Authors: Simmonds Bethany
Published: March 2024

This perspective paper begins with discussing how COVID-19 magnified the pre-pandemic ‘bare life’ conditions which exposed older people’s lives to risks and indignities in the health and social care system. Then, by using the concept of Necropolitics, the life and death decisions, based on age as a proxy measure for population health during the pandemic, are discussed. This discussion includes examples of ‘exceptional’ practices that were implemented in the UK during the first wave, including ‘Do Not Resuscitate’ orders, unsafe hospital discharges, not transferring to hospitals, and denying access to treatment for older people. It then goes on to renew the call for a feminist care ethic to be central to the ways in which our future health and social care systems are configured. Arguing for the need to politically reframe ageing, health and social care provision towards a radical alternative system that rethinks care relations and addresses inequality.
Strength in arms: empowering older adults against the risk of slipping and falling—a theoretical perspective
Authors: Lee-Confer Jonathan
Published: March 2024

Background

Slips and falls are a serious health concern, particularly among older adults. Current physical therapy protocols strengthen the legs to improve balance. However, arm movements help maintain balance during a slip incident. Understanding how arm movements improve balance may help clinicians develop more comprehensive fall-prevention protocols to improve patient outcomes.

Clinical question

What limitations exist in current fall prevention protocols for reducing falls in older adults during slip incidents, and what new strategies can enhance these outcomes?

Key results

Slip incidents often result in a sideways loss of balance, leading to hip fractures in older adults. During a slip, the legs do not produce sideways motion and are less effective in regaining balance in this direction. Contrary, the arms produce 100 + degrees of abduction and this motion reduces falls by 200%+ during a slip incident. Notably, older adults exhibit 35.7% decreased arm abduction acceleration responses compared to younger adults during a slip incident. This delay may be attributed to age-related decreases in type II fibers of the deltoid. High-velocity and ballistic training have been shown to improve the proportion and size of type II fibers as well as improve fall outcomes when focused on the lower extremities.

Clinical application

Therefore, I propose incorporating arm abductor training, alongside leg exercises, as a cost-effective and low-risk intervention to enhance the slip responses in older adults. In light of its minimal risk and considerable potential benefits, starting arm abductor exercises with older adults is a sensible move.
Advancing precision medicine therapeutics for Parkinson’s utilizing a shared quantitative systems pharmacology model and framework
Authors: Denaro Christopher , Stephenson Diane , Müller Martijn L. T. M. , Piccoli Benedetto , Azer Karim
Published: March 2024

A rich pipeline of therapeutic candidates is advancing for Parkinson’s disease, many of which are targeting the underlying pathophysiology of disease. Emerging evidence grounded in novel genetics and biomarker discoveries is illuminating the true promise of precision medicine-based therapeutic strategies for PD. There has been a growing effort to investigate disease-modifying therapies by designing clinical trials for genetic forms of PD - providing a clearer link to underlying pathophysiology. Leading candidate genes based on human genetic findings that are under active investigation in an array of basic and translational models include SNCA, LRRK2, and GBA. Broad investigations across mechanistic models show that these genes signal through common molecular pathways, namely, autosomal lysosomal pathways, inflammation and mitochondrial function. Therapeutic clinical trials to date based on genetically defined targets have not yet achieved approvals; however, much is to be learned from such pioneering trials. Fundamental principles of drug development that include proof of pharmacology in target tissue are critical to have confidence in advancing such precision-based therapies. There is a clear need for downstream biomarkers of leading candidate therapies to demonstrate proof of mechanism. The current regulatory landscape is poised and primed to support translational modeling strategies for the effective advancement of PD disease-modifying therapeutic candidates. A convergence of rich complex data that is available, the regulatory framework of model informed drug development (MIDD), and the new biological integrated staging frameworks when combined are collectively setting the stage for advancing new approaches in PD to accelerate progress. This perspective review highlights the potential of quantitative systems pharmacology (QSP) modeling in contributing to the field and hastening the pace of progress in advancing collaborative approaches for urgently needed PD disease-modifying treatments.
Ultrasonography of the neotropical primate female reproductive system
Authors: Domingues Sheyla Farhayldes Souza , Leão Danuza Leite , Monteiro Frederico Ozanan Barros
Published: March 2024

The Neotropical (e. g., Aotus sp., Callithrix jacchus, Saguinus sp., Saimiri sp., and Sapajus sp.) primates are important models for biomedical research and studies on reproductive physiology and biotechnology. Consequently, studies about gynecological and obstetric ultrasonography are crucial. B-mode ultrasonography is a non-invasive imaging technique that provides real-time bidimensional or three-dimensional/four-dimensional B-mode images. In association with Doppler ultrasonography, B-mode ultrasonography can also be used to monitor the mammalian blood flow to the reproductive tract during important events such as ovulation and gestation. Thus, gynecological and obstetric ultrasonography is essential for establishing the female reproductive anatomical and physiological ovarian and uterine health status, gestational diagnosis, and fetal growth monitoring. For instance, the paper presents and discusses the state-of-the-art gynecological and obstetric ultrasonography in the Neotropical primates, species that are models for biomedical research, and some recent studies on species targets for conservation strategies for wild animal populations.
Organizational Climate in Construction Companies: A Systematic Literature Review
Authors: Puente Riofrío Mariana Isabel , Mostacero Llerena Soledad Janett , Uquillas Granizo Gilma Gabriela
Published: March 2024

The construction industry is fraught with risks due to the use of heavy machinery and work at heights, leading to increased occupational accidents. Understanding how the work environment affects personnel adaptation is crucial, as a negative environment can have detrimental consequences on the physical and mental health of workers. The aim of this study is to identify and examine the significant dimensions, factors, and models related to the organizational climate, with a particular focus on the construction sector. A systematic literature review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol, utilizing the SCOPUS database, from which 176 studies were obtained through search strings. Of this set, 142 were selected for final analysis. The results reveal that China has the highest number of studies on the organizational climate in construction. Regarding dimensions, emphasis is placed on occupational health and safety. Factors include a classification for dimensions, models, and other general factors. The model identified in studies with the most relevance is the JD-R (job demands–resources) model, which helps us to understand how job characteristics promote employee well-being. The implications of this study underscore the need for further research related to the work environment, implementing changes in occupational safety and health, and highlighting the importance of fostering a positive work environment from the early stages of organizational development. These findings provide valuable insights to refine labor practices, design more effective models, and guide future research in the realm of organizational climate in construction sector companies.
Uncertainty Constraint on Headphone Secondary Path Function for Designing Cascade Biquad Feedback Controller with Improved Noise Reduction Performance
Authors: Hua Yang , Peng Linhui
Published: March 2024

The uncertainty in the secondary path of active noise control (ANC) headphones affects the waterbed effect and stability of the feedback system. This study focuses on the uncertainty of the secondary path when real users wear headphones and proposes a new uncertainty constraint based on the measured results of the secondary path transfer function under different wearing conditions of a dummy head and limited subjects. This constraint and a cascaded second-order infinite impulse response filter with fixed coefficients are used to formulate a control strategic function, which is optimized using the Improved Grey Wolf Optimizer (IGWO) algorithm to obtain the optimal controller with better noise reduction performance. The proposed method and simulation model are validated based on the experimental test results. The results demonstrate that the safety factor and waterbed suppressing factor contained in the proposed uncertainty constraint ensure more stable noise reduction and effective suppression of the waterbed effect for new subjects without a priori data.
It Ain’t Necessarily So: Ludwig Boltzmann’s Darwinian Notion of Entropy
Authors: Gimbel Steven
Published: March 2024

Ludwig Boltzmann’s move in his seminal paper of 1877, introducing a statistical understanding of entropy, was a watershed moment in the history of physics. The work not only introduced quantization and provided a new understanding of entropy, it challenged the understanding of what a law of nature could be. Traditionally, nomological necessity, that is, specifying the way in which a system must develop, was considered an essential element of proposed physical laws. Yet, here was a new understanding of the Second Law of Thermodynamics that no longer possessed this property. While it was a new direction in physics, in other important scientific discourses of that time—specifically Huttonian geology and Darwinian evolution, similar approaches were taken in which a system’s development followed principles, but did so in a way that both provided a direction of time and allowed for non-deterministic, though rule-based, time evolution. Boltzmann referred to both of these theories, especially the work of Darwin, frequently. The possibility that Darwin influenced Boltzmann’s thought in physics can be seen as being supported by Boltzmann’s later writings.
Buttock Augmentation with Ultrasonic Liposuction and Ultrasound-Guided Fat Grafting: A Retrospective Analysis Based on 185 Patients
Authors: Elsaftawy Ahmed , Ostrowski Patryk , Bonczar Michał , Stolarski Mateusz , Gabryszuk Kamil , Bonczar Tomasz
Published: March 2024

Background: The popularity of gluteal augmentation has surged in recent decades, primarily due to satisfactory aesthetic results. Objectives: The primary goal of this retrospective analysis was to present the key characteristics of a large patient cohort from Europe, comprising 185 female patients who underwent gluteal augmentation with ultrasound-guided fat grafting. Methods: A retrospective analysis was conducted on 185 female patients who underwent gluteal augmentation with ultrasonic liposuction and fat grafting from February 2020 to July 2023. The procedures were performed in accordance with the latest safety recommendations. Results: Information concerning the patient demographic, volume of fat graft, and complications was analyzed. Additionally, patient satisfaction was evaluated through a questionnaire. The mean Body Mass Index (BMI) of the patients was 23.00 kg/m2 (SD = 2.62). Furthermore, the volume of transferred fat graft ranged from 500.00 mL to 800.00 mL, with a mean of 596.75 mL (SD = 67.29). The most frequent complication was the formation of seroma (5.41%). All complications were treated successfully. Conclusions: Using ultrasonic liposuction and ultrasound-guided fat grafting to enhance buttock contours is a reliable technique. Nevertheless, it is crucial to exert caution and take all necessary steps to reduce the risk of potentially life-threatening complications.
Detailed One-Year Follow-Up in Left Bundle Branch Area Pacing: Echocardiography, Natriuretic Peptide, Electrical Parameters and Complications
Authors: Fularz Maciej , Mitkowski Przemysław
Published: March 2024

Background: LBBAP is a promising method of cardiac pacing. Data on some follow-up details are still limited. We aimed to evaluate LBBAP over a one-year follow-up period. Methods: The studied population consisted of 110 patients who underwent LBBAP device implantation (93 for bradycardia indications, 17 for CRT). Echocardiography and NT-proBNP measurement were performed before the procedure and after one year. Electrical parameters, complications and some other conditions that required attention were noted during the observation period. Results: In total, 89 patients completed the one-year follow-up. NT-proBNP and echocardiographic parameters (LVEF, left ventricular end-diastolic dimension, left atrium dimension) improved after the one-year follow-up, especially in the patients with CRT indications, but also in the bradycardia patients. The independent predictors of a positive heart function response were higher baseline NT-proBNP and the presence of either RBBB or LBBB. The electrical parameters were satisfactory but a slight raise in the pacing threshold was observed at subsequent control visits. Major complications occurred in 4.5% of patients in the acute phase and in 4.4% during the follow-up (the most common was dislodgement of the non-LBBAP lead). One patient is presumed to have developed pacing-induced cardiomyopathy. The most frequent mild complications were intraprocedural RBBB (9.1%) and conversion to deep septal pacing during the follow-up period (5.5%). In addition, 4.4% of the patients required individual programming of the pacing output to maintain the optimal type of capture. Conclusions: The impact of LBBAP device implantation on cardiac function parameters is positive in a wide range of indications, especially in patients with RBBB or LBBB. The prevalence of complications is relatively high but major complications are rarely associated with LBBAP issues.
Fractional-Order Model-Free Adaptive Control with High Order Estimation
Authors: Lv Zhuo-Xuan , Liao Jian
Published: March 2024

This paper concerns an improved model-free adaptive fractional-order control with a high-order pseudo-partial derivative for uncertain discrete-time nonlinear systems. Firstly, a new equivalent model is obtained by employing the Grünwald–Letnikov (G-L) fractional-order difference of the input in a compact-form dynamic linearization. Then, the pseudo-partial derivative (PPD) is derived using a high-order estimation algorithm, which provides more PPD information than the previous time. A discrete-time model-free adaptive fractional-order controller is proposed, which utilizes more past input–output data information. The ultimate uniform boundedness of the tracking errors are demonstrated through formal analysis. Finally, the simulation results demonstrate the effectiveness of the proposed method.