bluuebunny/crossref_metadata_2025 huggingface dataset:
Mellkas-CT textúraelemzése a COVID-19 okozta és más etiológiájú tüdőgyulladások elkülönítésére
Authors: Béresová Monika , Zilahi Anna , Berényi Ervin , Balkay László
Published: October 2024

A mellkas-CT-vizsgálatokat gyakran használták a COVID-19-megbetegedésben a tüdő kóros elváltozásainak kimutatására és a betegség progressziójának követésére. A textúraelemzés egy eszköz lehet a mellkas-CT kiértékelésében olyan betegeknél, akiknél a COVID-19-vírusfertőzéshez kapcsolódó tüdőgyulladás klinikai gyanúja áll fenn. Célunk volt felmérni a textúraanalízis jelentőségét a koronavírus és egyéb etiológiájú tüdőgyulladás megkülönböztetésében mellkas-CT-képeken. Módszerek: A 2020-as évből 53 igazolt COVID-19-diagnózissal rendelkező beteg és 2019-ből 53 kontrollszemély CT-képanyagának a textúraelemzését végeztük. Minden esetben interstitialis tüdőgyulladásra utaló, GGO (Ground Glass Opacity) CT-jelek voltak jellemzőek. A textúraanalízist LifeX programmal végeztük. A tüdőablakos CT-képeken a léziók VOI-kijelölése manuálisan történt a GGO centrumára fókuszálva. A 95 textúraindex közül a GLCM (Grey-Level Co-Occurrence Matrix), GLRLM (Grey-Level Run Length Matrix), GLZLM (Grey-Level Zone Length Matrix) és az NGLDM (Neighborhood Grey-Level Dependence Matrix) alapú paraméterekre fókuszáltunk. A statisztikai elemzést SPSS szoftverrel végeztük, a normalitásvizsgálat után kétmintás t-próba, Mann–Whitney U teszt és a ROC-görbe elemzése is történt. Eredmények: A szignifikáns különbséget mutató paraméterek száma 19 volt, és a textúra típusa szerinti megoszlásra a következőt kaptuk: GLCM – 6, GLRLM – 4, GLZLM – 7, NGTDM – 2. A ROC-görbe elemzésének eredménye AUC >0,8; p≤0,001 értékekkel megfelelő szenzitivitással és specificitással differenciálhatják a COVID-19 okozta tüdőgyulladást a más etiológiájú tüdőgyulladásoktól. Következtetés: A textúraanalízis nem invazív módszerként használható a COVID-19-ben előforduló tüdőgyulladás és a nem COVID-os tüdőgyulladás megkülönböztetésére, illetve segíthet a COVID-19-ben szenvedő betegek jobb prognózisában és diagnosztizálásában.
Korszerű komputertomográfiás eljárások szerepe a mozgásszervek képalkotó diagnosztikájában
Authors: Marton Nikolett , Gyebnár János , Csercsik Rita , Szöllősi Panna , Munkácsi Tamás , Purczel Tamás , Horváth Ákos , Gulácsi György , Menyhárt Ákos , Gyergyói Viktória , Bálint Péter Vince , Maurovich-Horvat Pál
Published: October 2024

A komputertomográfiás (CT) eljárások és az utólagos képfeldolgozási technikák az elmúlt évtizedekben jelentős fejlődésen estek át, ami a mozgásszervi vizsgálatok indikációs körét is bővítette. A klinikai gyakorlatban elterjedt energiaintegráló detektorokkal működő, multidetektoros CT-készülékek mellett megjelentek a spektrális képalkotásra alkalmas, kettős energiájú CT-k és a multienergiájú fotonszámláló CT-készülékek, a dinamikus vizsgálatot lehetővé tevő 4 dimenziós CT-felvételek, a helyszíni vizsgálatokra alkalmas kúpsugaras CT-k, illetve a végtagok nagy felbontású vizsgálatát lehetővé tevő perifériás CT-készülékek. A musculoskeletalis CT-technológia fejlesztése során a sugárterhelés csökkentése és a képminőség javítása mellett a fémes műtermékek eliminálása, jobb lágyrész-felbontás elérése, csontvelőödéma kimutatása, kristálydepozitumok differenciálása, csontok mikroarchitektúrájának részletgazdag megjelenítése mind kiemelten fontos szempont. A gyulladásos aktivitás meghatározására, tumorviabilitás mérésre lehet alkalmas a spektrális információkon alapuló jódtérképezés. A jelenlegi közlemény a vázrendszeri diagnosztikában kiaknázható CT-technológiák előnyeit és hátrányait, a mozgásszervi CT-vizsgálatokkal kapcsolatos technikai megfontolásokat, valamint a musculoskeletalis CT-vizsgálatok klinikai indikációit foglalja össze.
On the reception of Giacomo Leopardi in Georgia
Authors: Orlovskaja Natal’ja , Springfield Tomelleri Vittorio
Published: October 2024

In Georgia (Caucaso), la ricezione del poeta e pensatore italiano Giacomo Leopardi cominciò intorno alla metà del XIX secolo per il tramite di traduzioni russe di singole composizioni, selezionate in base alla situazione politica e alle esigenze del tempo. In una prima fase, la stampa periodica russa, e di riflesso quella georgiana, rivolse notevole attenzione alla particolare condizione dell’Italia, frammentata politicamente e soggetta alla dominazione straniera. In questo specifico contesto storico-politico, Leopardi emerse come il simbolo del poeta che cantava le disgrazie della patria e la lotta per la liberazione nazionale. Durante il primo periodo sovietico, l’interesse per Leopardi subì una pausa a causa delle condizioni ideologiche del tempo, poiché l’ispirazione lirica del poeta non rispondeva ai dettami del realismo socialista. Tuttavia, nella seconda metà del XX secolo l’interesse per Leopardi e le sue opere è aumentato considerevolmente: nuove traduzioni e materiali critici sono stati pubblicati in diverse riviste georgiane. In questa nuova fase, corrispondente al periodo dell’indipendenza della Georgia dopo il crollo dell’Unione Sovietica, Leopardi è divenuto ormai parte integrante della letteratura mondiale e come tale viene presentato e tradotto direttamente dall’originale.
La traducción del metalenguaje en las gramáticas del hispanismo italiano
Authors: Calleja Felisa Bermejo
Published: October 2024

En las gramáticas de la lengua española destinadas a italohablantes y publicadas a lo largo de los dos primeros tercios del siglo XX, se ha observado que diversos autores y autoras traducen la terminología gramatical empleada en la descripción de los fenómenos lingüísticos que presentan. El hecho de traducir el metalenguaje plantea varias cuestiones de interés; por ello, a partir de un corpus compuesto por ocho gramáticas, se determinará cuál es el alcance de la traducción terminológica. El objetivo último del presente estudio es valorar la necesidad, utilidad o conveniencia de la traducción de los términos gramaticales a la hora de facilitar u obstaculizar la enseñanza- aprendizaje de la lengua.
Guest Editorial: What do we pay attention to? Digital innovations in the competition for attention
Authors: Bachmann Philipp , Moist Richard , Sandmeier Fabio
Published: October 2024

There are only 24 hours a day, and our capacity for attention is limited. Yet, in our digital world, everything and everyone competes for this attention, using a wide range of technical and psychological strategies. This “hypercompetition” for attention was chosen as the theme for the annual conference of the Swiss Association of Communication and Media Research, held in April 2023. The conference, titled “What Do We Pay Attention To? Digital Innovations in the Competition for Attention,” was hosted by the Institute of Communication and Marketing at Lucerne University of Applied Sciences. We want to draw your attention to four contributions presented at the conference. The four articles in this Thematic Section contribute to understanding the competition for attention from distinct and varied perspectives. Hence, we hope you will devote some of your precious attention to exploring these enlightening articles.
Inclusion of Students With Disabilities in Physical Education: The Crossroads of Systemic Coherence
Authors: Fierro-Saldaña Belén , Treviño-Villarreal Ernesto
Published: October 2024

This study aims to identify and comprehend the factors and pedagogical practices that facilitate or hinder the inclusion of students with disabilities in physical education classes at school, considering micro and macrosystemic levels. The methodology employed in this study was a case study approach, using an interpretative phenomenological analysis to construct thematic categories of analysis. These categories include: 1.Flexibility of the physical education teacher’s practices and strategies, 2. Teacher training, 3. Inclusive spaces and infrastructure, 4. Involvement of the educational community. The various data collection tools (interviews, focus groups and observations) allowed to portray and illuminate each of the topics of analysis and the contextual differences of the three schools analyzed. The findings demonstrate that inclusive strategies must be coherent and systemic in accordance with the contexts. However, it is possible to highlight inclusive strategies that reveal the importance of teacher commitment, the interconnected work between teachers and school management, the use of expeditious communication channels within the educational community and with governmental levels, the use of implements related to the practice of physical education and the use of the teacher’s voice as the primary agent for the implementation of inclusive learning strategies.
Alguns contributos para a compreensão da construção médico-social da infância em Portugal (1820-1950)
Authors: Rocha Cristina , Ferreira Manuela
Published: October 2024

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A domesticação escolar do pensamento infantil: Perspectivas teóricas para a análise das práticas escolares
Authors: Reis Filipe
Published: October 2024

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Um contributo para a história do processo de escolarização da sociedade portuguesa na transição do antigo regime
Authors: Magalhães Justino
Published: October 2024

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Meninos entre árvores e lianas: Aprendizagem do mundo e das plantas pelas crianças Nalus (Guiné-Bissau)
Authors: Frazão-Moreira Amélia
Published: October 2024

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Convertidos e oblatos: Um exame da relação classes médias/escola na obra de Pierre Bourdieu
Authors: Nogueira Maria Alice
Published: October 2024

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Um estudo de caso sobre as explorações do ChatGPT no desenvolvimento do letramento probabilístico
Authors: Giordano Cassio Cristiano , Kistemann Junior Marco Aurélio , Souza Fabiano dos Santos
Published: October 2024

A Base Nacional Comum Curricular ampliou o espaço da Probabilidade na educação básica brasileira e criou novas oportunidades e novos desafios para os professores, com a introdução da probabilística frequentista e de demandas que requerem a absorção de tecnologias digitais nas aulas de Matemática. No currículo da rede estadual paulista, uma nova componente curricular foi criada no Ensino Médio, na condição de Itinerário Formativo:   Certeza e Incerteza: para que serve a Probabilidade - Tendências e Decisões. Nesse contexto, analisou-se o apoio da Inteligência Artificial, por meio do ChatGPT, nas investigações dos estudantes acerca das situações que envolvem acaso e aleatoriedade. Os resultados apontam para o potencial da Inteligência Artificial para a promoção do letramento probabilístico.
The State of Nature: Ecogothic (Mo)Other in Catalina Infante’s “Todas Somos una Misma Sombra”
Authors:   Universidad de Granada (España), Torres Montesinos Juan Ignacio
Published: October 2024

This paper analyzes “Todas somos una misma sombra,” a short story by Chilean writer Catalina Infante published in 2018. The story describes the evolution of a community where men extinguish and women, as a joint shadow, walk to interweave with nature. Sun has vanished so the analysis is conceived from the ecogothic premise of fear to climate disorder. Such an alteration is the symbolic result of the ecosocial system of Anthropocene.The study considers the archetype of the state of nature proposed by English philosopherThomas Hobbes. It expresses the fear human beings experience before reaching a pact to live in society. Catalina Infante’s text describes an itinerary of be-coming where women’s perception of nature is summarized by the idea of (M)other. Due to a new social pact based upon ecofeminism, the primary perception of otherness turns into the comprehension of nature as mother. The sense of shelter creates an imperative of preservation. “Todas somos una misma sombra” condenses those arguments and shows the theoretical suitability of the state-of-nature concept to analyze ecogothic literature.
An Ecogothic Reading of Sea Monsters: Deep Blue Sea (1999) and The Meg -2018
Authors:   Universidad de Alcalá (España), Sanz Alonso Irene
Published: October 2024

Even though our planet is mostly covered by water, seas and oceans are still considered inhospitable environments where the force of nature can be appreciated in all its splendor. It is perhaps this unconquerable character that makes humans perceive marine ecosystems with a mixture of awe and horror, feelings which may be increased if we think of the unknown creatures that populate the depths of the ocean. This article will look at two films which Meg (2018), and it will do so by using an ecogothic approach. The analysis will focus on why these movies could be catalogued as ecogothic by observing on their settings, their characters v and to the creatures that inhabit it, particularly with different forms of sharks, including their ancestor, the megalodon, emphasizing how these relationships tend to be portrayed as a fight for control. Furthermore, the representation of these nonhuman animals’ agency will also be considered with the aim of raising awareness about the dangers of humans’ attempts to control and manipulate nature.
Hábitos alimentares na infância, um olhar para o presente para projetar o futuro
Authors: Tudino Isadora Gori , Balbé Gabriel Ourique , Baccon Ana Flávia Gaio , Moreira Marina Laís Hahn , Soccol Gabriela , Scipioni Ana Luiza , Martins Patricia Domingos Noro da Silva
Published: October 2024

Objetivo: Relatar a experiência e expor o ponto de vista dos acadêmicos de medicina do 2º ano, por meio da matéria de Interação Comunitária II, com intuito de orientar e conscientizar as crianças sobre mudanças de hábitos alimentares com prática teórica e um projeto de intervenção. Relato de experiência: Tendo em vista o contexto desafiador da educação nutricional na infância, o qual exige criação de abordagens educativas para modificar hábitos e práticas alimentares havendo a necessidade de conscientização sobre alimentação mais adequada na época da vida que têm influência direta no desempenho cognitivo, escolar e na criação de preferências alimentares. Nesse sentido, introduziu-se a ação na escola com o intuito de apresentar a importância e o impacto da boa alimentação na vida das crianças e com essa experiência foram obtidos resultados positivos. Considerações finais: Salientou-se que a alimentação saudável tem papel fundamental, principalmente nos primeiros anos da infância, os quais com uma boa prática alimentar são decisivos para uma melhor qualidade de vida da criança. Desenvolvem uma melhor conscientização acerca do impacto de uma dieta nutritiva, trazendo resultados positivos não apenas no desempenho escolar, como também no seu desenvolvimento.
Transtorno mental associado ao trabalho: análise epidemiológica da região Sul do Brasil
Authors: Beraldi Pedro Otávio Capelasso , Lopes João Pedro , Vasconcelos Sandra Sayuri Nakamura de
Published: October 2024

Objetivo: Investigar o perfil epidemiológico dos casos de transtornos mentais relacionados ao trabalho (TMRT) na região Sul do Brasil no período entre 2007 e 2023. Métodos: Trata-se de um estudo epidemiológico, quantitativo e descritivo que utilizou dados secundários do Sistema Nacional de Agravos e Notificação (SINAN), do banco de dados do Departamento de Informática do Sistema Único de Saúde (DATASUS). Resultados: No período analisado foram notificados 3.000 casos e as mulheres (73,9%), entre 20 e 59 anos (95,3%), de cor branca (72,7%) e com nível médio e superior de ensino (63,6%) foram as mais acometidas. Quanto às variáveis clínicas, destaca-se alta prevalência do uso de medicamentos psicotrópicos (31%). Notou-se ainda que 36,4% dos trabalhadores diagnosticados com TMRT foram afastados trabalho; receberam tratamento ambulatorial (79,7%) e a evoluíram para uma incapacidade temporária (34,4%). Foi observada uma incompletude das fichas de notificação com uma alta percentagem de dados “ignorados” ou “em branco” o que prejudicou sobremaneira o conhecimento do real cenário desse agravo na região Sul do Brasil. Conclusão: Um número considerável de casos de TMRT foi notificado na região Sul do Brasil durante o período analisado, no entanto, novas pesquisas são necessárias para que o adoecimento laboral seja totalmente compreendido.
Chronic subdural hematoma: Management, sequelae with its predictive factors, and health-related quality of life of survivors
Authors: Javeed Farrukh , Shakeel Alisha , Khan Muhammad Zohaib
Published: October 2024

Objectives:

The objective of the study is to identify the risk factors associated with chronic subdural hematoma (CSDH) in the Pakistani population, to compare various surgical techniques commonly used in its management, and to analyze the outcomes of patients, including early, that is, at the time of discharge, and late, that is, the disability status of patients on follow-up after ≥6 weeks.

Materials and Methods:

This retrospective study was carried out at a tertiary care hospital in Pakistan between March 2023 and October 2023 and included 100 patients with CSDH. All patients underwent surgical procedures, and outcomes were assessed at six weeks.

Results:

The mean age of the patients diagnosed with CSDH in this study was 53.81 ± 11.54 years. The most commonly reported symptom was an altered level of consciousness (30%), but most patients presented with more than one symptom (50%). Mortality was associated with only 10% of cases, and 90% reported no complications or significant morbidity. The most commonly used surgical technique was two burr-hole drainage (67%). The risk of recurrence was increased with the presence of comorbidities (P = 0.001) and remarkably reduced with intraoperative subdural drain placement (P = 0.000).

Conclusion:

The choice of surgical technique had no influence on the length of stay in the hospital or functional status post-discharge but surgery with intraoperative subdural drain placement proved to yield definitive favorable outcomes.
Штрихи к портрету последнего российского императора
Authors: К.А. Золотарева
Published: October 2024

В статье идет речь о последнем императоре России, его личных и деловых качествах, мировоззрении, видении способов управления российским государством, крахе его замыслов и надежд.

The article deals with the last emperor of Russia, his personal and business qualities, worldview, vision of the methods of governing the Russian state, the collapse of his plans and hopes.
Study of the Correlation between Vibraimage Parameters and the Comprehensive Result of Military Service Adaptability Test
Authors: J.K. Choi , J.Ik. Hong
Published: October 2024

This study compared and analyzed correlations between the results of Military Service Adaptability Test, as a self-examination tool by vibraimage (VI) parameters tested by MAUMLENZ system. MAUMLENZ system was modified and developed by MINDEYE in Korea for testing and monitoring psychophysiological state based on VI technology. The Military Service Adaptability Test is comprehensively judged in four categories according to the severity: “GOOD, CAUTION, ATTENTION and ADDITIONAL CHECK REQUIRED”. The final results of Military Service Adaptability Test were classified and collected by two groups — “Normal” group “Warning” group. 37 Vibraimage parameters were collected by MAUMLENZ system. In the results of mean value, there were the significant differences in Stress(p = 0.041) and Energy(p = 0.005). In the results of variability value, Stress (p = 0.022), Tension(p = 0.021) and Energy (p = 0.045) were significantly different also as significantly different in Concentration (p = 0.012), Extraversion(p = 0.011), Average value of Information efficiency (p = 0.011), Standard Deviation of Frequency Histogram (p = 0.041), P21 indicator (p = 0.045), P22 indicator(p = 0.028). Especially, 3(three) parameters — Energy mean value(p = 0.005), Pleasure/Displeasure (p = 0.003) and Minimum value of Information efficiency (p = 0.005) were significantly different at 99% confidence level. And 11 parameters showed the 95% confidence level.
Construct validity of the Minnesota Multiphasic Personality Inventory (MMPI), 16 Personality Factor Questionnaire (16PF), Big Five Personality Traits (BFI), Neurolinguistic Profiling Blitz Judgment Program (BJP) in Complex Personality Assessment
Authors: Я.Н. Николаенко
Published: October 2024

Обсуждается проблема отсутствия единого подхода к оценке качества психодиагностических методик; проблема разобщенности мировых сообществ, ответственных за разработку методик психологического тестирования и структурной валидности опросников. На примере опросника MMPI, опросника Кеттела (16PF), теста Большой пятерки (BFI) и нейролингвистической программы Профайлер+ (на базе технологии виброизображения) анализируется структурная и прогностическая валидность. Обсуждаются преимущества методик комплексной оценки личности на базе измерения сознательной и бессознательной реакций по отношению к классическим опросникам и необходимость математической проверки полноты структуры личности.

The problem of the lack of unified approach to assessing the quality of psychometrics techniques is discussed; the problem of disunity of world communities responsible for the development of psychological testing methods and constructive validity of questionnaires. Using the example of Minnesota Multiphasic Personality Inventory (MMPI), 16 Personality Factor Questionnaire (16PF), Big Five inventory (BFI), neurolinguistic profiling (Blitz Judgment program or BJP), the construct and predictive validity of the techniques is examined. The advantages of methods for comprehensive personality assessment based on advanced vibraimage technology in relation to classical questionnaires are discussed.
What Cats are Silent About: Analysis of the Psychophysiological State of Domestic Cats Using Vibraimage Technology
Authors: Я.Н. Николаенко , В.А. Акимов
Published: October 2024

В статье рассматривается проблема уважительного отношения к личности и душевному здоровью животного (домашних кошек) в период проведения научных экспериментов. Предлагается использовать современные цифровые технологии — ПО Vibraimage Pro10 на базе технологии виброизображения как гуманный и точный метод исследования текущего психофизиологического состояния (ПФС) животных. Представлены результаты сравнительного анализа текущего ПФС домашних кошек при разных видах естественного поведения: сна (естественный физиологический сон); периода бодрствования, на фоне нейтрального эмоционального состояния; периода бодрствования, на фоне положительных эмоций (после вкусной еды или ласк хозяина). Показана зависимость поведенческой активности домашних кошек от текущего ПФС.

The article discusses the problem of respect for the personality and mental health of an animal (domestic cats) during the period of scientific experiments. It is proposed to use modern digital technologies — VibraPro10 software, based on vibraimage technology, as a humane and accurate method for studying the current psychophysiological state (PPS) of animals. The results of a comparative analysis of the current PPS of domestic cats during different types of natural behavior are presented: sleep (natural physiological sleep), the period of wakefulness, against the background of a neutral emotional state; period of wakefulness, against the background of positive emotions (after a delicious meal or the caress of the owner). The dependence of the behavioral activity of domestic cats on the current PFS is shown.
Characteristics of Personality Accentuations for Military Personnel with Various Prognostic Signs of Professional Success and Professional Orientation
Authors: М.Р. Назарова , Е.С. Щелканова
Published: October 2024

Статья посвящена исследованию акцентуаций личности военнослужащих по К. Леонгарду с помощью технологии виброизображения. Рассмотрены вопросы объективной, комплексной диагностики акцентуаций личности, а также их взаимосвязь с показателями профессиональной успешности и профессиональной направленности. В результате исследования установлены достоверные отличия по типам акцентуаций у лиц с различными прогностическими признаками успешности и направленности профессиональной деятельности. Установлена высокая взаимосвязь акцентуаций личности с элементами профессиональной направленности. У лиц с различными прогностическими характеристиками профессиональной успешности характер этой взаимосвязи различный. Результаты исследования могут быть положены в основу создания системы профессионального отбора граждан, включающей объективные экспресс-методы диагностики личностных особенностей.

The article is devoted to the study of the accentuations of the personality of military personnel according to K. Leonhard using vibraimage technology. The issues of objective, complex diagnostics of personality accentuations, as well as their interrelation are considered with indicators of professional success and professional orientation. As a result of the study, significant differences in the types of accentuation were found in individuals with different prognostic signs of success and orientation of professional activity. A high correlation of personality accentuations has been established with elements of a professional orientation. Individuals with different prognostic characteristics of professional success have a different nature of this relationship. The results of the study can be used as a basis for creating a system of professional selection of citizens, including objective express methods for diagnosing personal characteristics.
Mathematical Search for the Relationship Between Indicators of Different Nature on the Example of the Results Analysis of Psychophysiological Testing by Blitz Judgment Program
Authors: А.Ф. Бобров , Л.И. Фортунатова , Н.Л. Проскурякова , Ю.В. Лихачев
Published: October 2024

Рассмотрены многомерные математические методы для поиска взаимосвязи между медико-биологическими показателями различной природы, выделяемых в соответствии с иерархией различный функций организма: факторный и канонический корреляционный анализ. Логика и результаты их применения демонстрируются на результатах анализа открытой базы данных психофизиологического/психологического тестирования с использованием программы Профайлер+. Обсуждается классификация множественных интеллектов для работников опасных производств, оппозитное или прямое дихотомическое соответствие между ними при тестировании с 16-секундным интервалом между стимулами (программа ВибраМИ). Обсуждается изменение факторной структуры множественных интеллектов при тестировании в режиме программы Профайлер+ (5 сек интервалы между стимулами). Анализ взаимосвязи психофизиологических реакции на стимулы оценки способностей и моральных качеств показал их высокое соответствие (коэффициент канонической корреляции равен 0,82), что обусловлено одинаковым уровнем активации нервной системы вне зависимости от характера стимула. Взаимосвязь бальных оценок этих характеристик существенно ниже: коэффициент канонической корреляции равен 0,32. Это свидетельствует, что бальные характеристики, в отличие от психофизиологических реакций, являются относительно независимыми. Показано усиление взаимосвязи до 0,52 у лиц с напряжением механизмов психической адаптации

Multidimensional mathematical methods are considered to search for the relationship between biomedical indicators of various nature, allocated in accordance with the hierarchy of various body functions: factorial and canonical correlation analysis. The logic and results of their application are demonstrated based on the results of an analysis of an open database of psychophysiological/psychological testing using Blitz Judgment program (BJP). The classification of multiple intelligences (MI) for workers in hazardous industries, the oppositional or direct dichotomous correspondence between them when tested with a 16-second interval between stimuli (vibration program) is discussed. The change in the factor structure of MI during testing in BJP mode (5 sec intervals between stimuli) is discussed. The analysis of the relationship between psychophysiological responses to stimuli of assessment of MI and personality vices showed their high correspondence (the coefficient of canonical correlation is 0.82), which is due to the same level of activation of the nervous system, regardless of the nature of the stimulus. The correlation of the scores of these characteristics is significantly lower: the canonical correlation coefficient is 0.32. This indicates these characteristics are relatively independent. It is shown that the relationship increases to 0.52 in persons with stress of the mechanisms of mental adaptation
Morbidity & Mortality in Patients with Human Immunodeficiency Virus Infection Undergoing Open Heart Surgery in an Integrated Healthcare System
Authors:   Department of Anesthesiology, Kaiser Permanente Los Angeles Medical Center, USA, Conte Antonio Hernandez
Published: October 2024

Objective: This study sought to evaluate presurgical HIV-related immune characteristics and elucidate outcomes in HIV+ patients who underwent open heart cardiac surgery. Design: Retrospective IRB-approved study utilizing hospital electronic medical records and Society of Thoracic Surgeons database. The study was conducted within a single integrated healthcare system where subjects underwent surgery at two hospitals. Participants: Subjects were HIV+ patients who underwent open heart cardiac surgery from January 1, 2000 to December, 31, 2021 and followed for a period of two years postoperatively. Data review with no active interventions; subjects had undergone open heart surgery.
A Review on: Effect of Nutrients on Brain Function and Development
Authors:   National Institute of Food Science and Technology, University of Agriculture Faisalabad, Pakistan, Riaz Faiqa
Published: October 2024

Introduction: Nutrition is one of the critical factors that influence brain development, and has a significant impact on the brain’s developmental processes and functioning from foetal to adult age. Newborn human brains utilise 60% of the body’s total oxygen, which has an impact on calorie intake. For the anatomical and functional growth of the brain, all nutrients are essential, the ones that aid in energy, carbohydrate, protein, and fat metabolism are especially significant. Objectives: The aim of this review is to boost up memory through diet, to know about the Nutrients for the development of the brain and to ensure Foods that adversely affect normal brain function. Methodology: This literature review consulted multiple databases, focusing on brain health and development, cognitive function, and maternal diet. The review included research from previous decades and analysed around 1,000 articles, with nearly 185 selected. The review assessed the relevance of the content to search terms, evaluating resources based on material quality, topicality, and publication year. The review discussed macronutrients and micronutrients, healthy and unhealthy foods, and maternal diets for foetal brain development. Conclusion: Factors such as maternal diet and macro and micronutrient consumption significantly impact brain development and cognitive function. Nutrition is crucial for optimal brain health and preventing cognitive decline. Deficiencies and excesses of certain nutrients affect cognitive function differently. Vitamin A, LC-PUFAs, ketones, protein, zinc, neurotrophins, neuropeptides, choline deficiency, vitamin B, copper, lutein, and zeaxanthin are essential for brain health. Consuming foods like walnuts, dairy, fish, caffeine, and low glycemic index foods can be beneficial for brain health, while junk foods, refined sugar, and saturated fats can be harmful.
A Scoping Overview of Global Legislation on Data Privacy and Protection: What are the Implications for Data Use, Transfer, and Sharing in E-Health Research?
Authors:   Centre for Public Health Research, Kenya Medical Research Institute- Nairobi, Kenya, VW Wanjihia , BK Muriithi ,   Institute of Tropical Medicine, Nagasaki University-Kenya Medical Research Institute, Nairobi, Kenya, S Kaneko ,   Department of Eco-epidemiology, Institute of Tropical Medicine, Nagasaki University. Nagasaki, Japan
Published: October 2024

Integration of digital technologies into health-care is positively impacting health outcomes globally. Consequently, creating need for regulation to ensure proper usage and transfer of data in digital platforms, while promoting its protection and privacy of data subjects. This scoping review investigates state of data privacy and protection legislation globally and analyses its impact on eHealth research. The review examines various legislations in terms of coverage, strengths, weaknesses and recommendations in the context of biomedical research. It employs a methodological framework based on PRISMA-ScR checklist. Results indicate lack of harmonized data protection laws and robust data governance frameworks. There are limited safeguards to ensure security and ethical use of digital data in e-health research. There is also lack of clear legislation regarding the classification of encrypted data, and the need to simplify legal language to prevent non-compliance. Issues like, defining data subjects’ rights to opt out of data processing, establishing a consential age for data use, and protecting children’s data are inadequate in some legislations. There is also limited regulatory oversight, and insecure data transfer methods. Recommendations emphasize the need to encourage global enhancement of privacy standards and to treat data protection as a fundamental human right. Enhanced data subject privacy will foster scientific collaboration. Enforceable data subject rights and responsibilities for data processors that extend beyond territorial boundaries are recommended. Balancing privacy and data subject rights with advancing digital health research is the way forward. Unified bilateral or multilateral agreements to enhance data protection laws will ensure cohesive data governance.
Harnessing Carbene Reactivity of [1.1.1]Propellane for [2,3]-Sigmatropic Rearrangement: Application and Mechanistic Studies
Authors: Midya Suparnak , Ali Aksar , Hari Durga Prasad
Published: October 2024

[1.1.1]Propellane is a highly strained smallest tricyclic hydrocarbon, and its reactivity is primarily engrossed by addition reactions across the strained C-C bond, leading to the formation of bicyclo[1.1.1]pentane derivatives. Herein, we present an unprecedented [2,3]-sigmatropic rearrangement that uses [1.1.1]propellane as a carbene precursor to rapidly access allenylated or allylated methylenecyclobutanes. The reaction is highly efficient and scalable, works well under mild conditions, and can tolerate remarkable functional groups on propargyl and allyl sulfides/selenides. Another significant achievement of this approach is the utility of the obtained products in synthesizing substituted bicyclo[2.1.1]hexanes, potential bioisosteres of ortho and meta-substituted benzenes, by developing a novel photocatalyzed radical cascade cyclization. Density functional theory calculations have suggested that the mechanism of this reaction proceeds via a Cu(I)-assisted five-membered envelope transition state to give the [2,3]-rearrangement product.
Silver-promoted solid-phase guanidyl-formation triggered peptide stapling and cyclization: A robust platform for improving multiple properties of bioactive peptides
Authors: Wang Nan , Chen Baobao , Li Xiang , Hu Hong-Gang
Published: October 2024

Stapled or cyclic peptides offered advantageous membrane permeability and proteolytic stability to linear counterparts. We herein synthesized a series of S-alkyl-isothiourea building blocks, which could be conveniently coupled with one or two amine groups in both i,i+4 and i,i+7 space located within the peptides, enabling the silver-promoted solid-phase guanidyl-formation (SSG) peptide stapling. The guanidyl stapled peptides, characterized with highly hydrophilic and cationic properties, could be readily labelled by biotin, polyethylene glycol and fluorescent motif using the pre-made functionalized bis-S-alkyl-isothiourea. SSG reactions could be rendered for generating double-stapled peptide, and notably, tri-guanidyl bicyclic peptide with the aid of tri-S-alkyl-isothiourea donor. When compared with hydrocarbon stapled and/or linear peptide, SSG stapled peptides exhibited enhanced proteolytic tolerance, remarkable hydrophilicity, membrane penetration and thus higher in vitro biological activities. Our developed SSG peptide stapling and cyclization strategy served as a meaningful tool in modifying other peptide fragments and offering the potent peptide therapeutic candidates.
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
Authors: Zhuang Zhe , Byun Woong Sub , Kozicka Zuzanna , Donovan Katherine , Dwyer Brendan , Thornhill Abby , Jones Hannah , Jiang Zixuan , Zhu Xijun , Fischer Eric , Thoma Nicolas , Gray Nathanael
Published: October 2024

Targeted protein degradation (TPD) is an emerging therapeutic approach for the selective elimination of disease-related proteins. While molecular glue degraders exhibit drug-like properties, their discovery has traditionally been serendipitous and often requires post-hoc rationalization. In this study, we demonstrate the rational design of molecular glue degraders using gluing moieties. By appending a chemical gluing moiety to several small molecule inhibitors, we successfully transformed them into degraders, obviat-ing the need for a specific E3 ubiquitin ligase recruiter. Specifically, we found that incorporating a hydrophobic gluing moiety into a cyclin-dependent kinase 12 and 13 (CDK12/13) dual inhibitor enabled the recruitment of DNA damage-binding protein 1 (DDB1), thereby transforming a high-molecular-weight bivalent CDK12 degrader into a potent monovalent CDK12/13 molecular glue de-grader. We also showcase that attaching a cysteine-reactive warhead to a BRD4 inhibitor converts it into a degrader by recruiting the DDB1 and CUL4 associated factor 16 (DCAF16) E3 ligase.
Efficacy and toxicity analysis of selective BET bromodomain inhibitors in models of inflammatory liver disease
Authors: Doskey Luke , Scholtz Cole , Vail Nora , Khanal Shalil , Lee Amani , Kandanur Sai Giridhar Sarma , Hoell Zachariah , Huehls Amelia , Issa Mohamed , Kostallari Enis , Cao Sheng , Reid Joel , Malhi Harmeet , Shah Vijay , pomerantz william
Published: October 2024

BET bromodomain inhibitors demonstrate significant promise as anti-inflammatory agents targeting a variety of inflammatory disorders. However, clinical data has demonstrated that the administration of non-selective BET bromodomain inhibitors has led to significant dose-limiting toxicity in clinical settings. More selective inhibitors of the second BET bromodomains, referred to as pan-D2 inhibitors, are better tolerated, however their efficacy varies significantly depending on disease indication. Here, we use three orally bioavailable inhibitors, 1–3, that are either selective for the first N-terminal bromodomain of BRD4 (BRD4-D1 selective), or pan-D1 biased, for assessing their cellular and in vivo efficacy and safety profile in two models of inflammatory liver disease. We compare their effects to known pan-D2 and pan-BET inhibitors. Our results show that pan-D1 biased inhibitor, 3, is as efficacious as the pan-BET inhibitor I-BET151 in reducing inflammation from LPS-induced and drug-induced toxicity, whereas pan-D2 inhibitors are less effective. BRD4-D1 selective inhibitors, 1 and 2, are also efficacious; however, new inhibitors with improved cellular target engagement will be necessary to more thoroughly assess their effects. Finally, BRD4-D1 selective inhibitors are better tolerated in a preclinical model of thrombocytopenia than pan-D1 biased inhibitors, while gastrointestinal (GI) toxicity may be a BRD4-driven effect. These results highlight the importance of assessing specific BET protein and bromodomain functions due to their varying roles in diverse disease models.
DART: Unlocking Coordination Chemistry Beyond the Cambridge Structural Database
Authors: Clarke Cian , Sommer Timo , Kleuker Felix , García-Melchor Max
Published: October 2024

Computational high-throughput screening has become an essential tool in modern research, accelerating the discovery of novel compounds with tailored chemical reactivity and electronic properties. Metal complexes, with their versatile combinations of metal centers and ligands, offer vast potential for tuning their properties across a wide range of applications. This flexibility can be harnessed by computational algorithms that use ligands and metal centers as modular building blocks to create new molecules for exploration. However, there remains a need for a unified platform that integrates ligand databases, filters, and assembly algorithms into a single user-friendly framework, but also incorporates customizable ligand filters to precisely target novel metal complexes for specific applications. Here, we introduce DART (Directed Assembly of Random Transition metal complexes), an intuitive, end-to-end computational platform for automating the targeted assembly of monometallic complexes. Central to DART is the MetaLig database, containing 41,018 unique ligands extracted from the Cambridge Structural Database, each with automatically assigned formal charges. DART can generate up to 500 billion unique neutral molecular complexes in octahedral and square planar 3D structures by selecting ligands from the MetaLig database. Its assembler module enables the exploration of user-defined chemical spaces through customizable ligand filters, allowing DART to overcome the limitations of empirical databases, which are shaped by historical research trends and restricted to crystallizable structures, thereby enabling the exploration of novel chemistries. To demonstrate DART’s potential, we present a case study modeling intermediates in the oxidative addition step of transition metal-catalyzed C–C cross-coupling reactions. Within minutes, we assembled 620 square planar Pd and Ni complexes with P,N-type ligands. Subsequent density functional theory calculations revealed a broad spectrum of electronic properties for these intermediates, showcasing DART’s ability to facilitate targeted molecular design for complex research challenges.
Structural insight into Aurora A kinase based on molecular dynamics simulations
Authors: Abdullah Maaged
Published: October 2024

Aurora A kinase is one of the important targets for cancer and has inhibitors in clinical trials and due its high numbers of crystal structures that are deposited in RCSB database make it as good target to understand its mechanism. I have studied Aurora A kinase domain with its important residues using molecular dynamics simulations (MD simulations), and deeply I focused on regions as DFG motif, alpha-C-helix, HRD motif and activation loop. Two system of Aurora A complexes (protein-inhibitor) were selected to evaluate their flexibility and understand all changes and screening important interactions. The first complex of Aurora A which is described as inactive form and its DFG-out is in vertical state, and second complex of Aurora A kinase and its DFG available as DFG-in, and from multiple of MD simulations runs I identified important structural changes and transitions, The result provides clarification to understand flexibility of Aurora A for active and inactive forms and other nearest parts. The work was performed using MD simulations in nano to micro-second, and the result was compared with reported crystal structures of Aurora A as monomers and dimers.
A BRIEF OVERVIEW OF DEEP LEARNING'S POTENTIAL FOR MRI IMAGE BASED ALZHEIMER'S DISEASE PREDICTION
Authors:   Research Scholar Department of Computer Science  Dr.N.G.P.Arts and Science College  Coimbatore- 641048, Tamilnadu, India, Karpagam S.
Published: October 2024

Cognitive capacities gradually deteriorate with the onset of Alzheimer's Disease (AD), an irreversible neurological disease. As the disease progresses, it gradually robs people of their ability to control their movements and other brain functions. Initiating therapeutic measures that can impede the advancement of the disease is made possible by early detection. To detect structural and functional alterations linked to AD, Magnetic Resonance Imaging (MRI) offers high-resolution pictures of the brain. However, owing to typical aging overlap and brain architecture diversity, MRI picture interpretation might be difficult. In order to conduct a longitudinal study, sophisticated analytic methods and highly trained radiologists are required. This problem has been addressed in recent decades with the emergence of Deep Learning (DL) systems that automatically detect and classify AD using MRI scans. DL models are able to learn from complicated patterns and enormous datasets, allowing for early diagnosis and the detection of minor changes in brain structure prior to clinical signs. This study provides a comprehensive analysis of various DL frameworks that have been created for the purpose of AD picture recognition and classification using MRI. A number of AD classification systems built using DL algorithms have been briefly reviewed at the outset. In order to regulate the global morality rates, it is necessary to predict and classify MRI-based AD effectively. A comparative analysis is then performed to analyse the shortcomings of such algorithms and propose a new approach.
DEVELOPMENT OF AN EFFICIENT STUDENT HALL REGISTRATION AND EXEAT SYSTEM
Authors:   Computer Science Department School of Computing, Babcock University, Ilishan Remo, Ogun State Nigeria, Oyebola Akande
Published: October 2024

The current student’s hall registration and exeat system in private owned Nigerian higher institutions uses manual or paper-based approach. This method is cumbersome, susceptible to mistakes, and poses security concerns. The aim of this project is to develop a web-based student hall registration and exeat system (SRES) that enhances student housing management by automating and streamlining the processes for registration and exeat processes using scrum process model. Thus, students can register and request for exeat online by submitting necessary documents. The request will be reviewed by authorized school administrator who will either accept or reject the exeat based on whether reasons and documents supplied are satisfactory or not. The SRES implements a comprehensive data management system, making physical records obsolete. By consolidating student information, the university gains efficient oversight of residency status, streamlining administrative processes and enhancing security. Moreover, the SRES fosters a better learning atmosphere by easing the hall registration procedures and minimizing delays in exeat approvals, allowing students to focus on their academics
Bikefinder prototipo para localización y gestión de bicicletas alquiladas con tecnología GPS
Authors: De Avila Gutierrez Lourdes , Mendoza Sarmiento Karen Lizeth , Becerra Chica Juan José , De La Hoz Hernández Osman Andrés
Published: October 2024

El proyecto busca desarrollar un prototipo de un sistema de localización y gestión de alquiler de bicicletas mediante tecnología GPS. El prototipo se enmarca en el creciente uso de bicicletas compartidas como forma de transporte sostenible y saludable. El sistema estará implementado en Arduino y contará con una página web. El dispositivo ESP32 se instalará en el marco de la bicicleta y se conectará a un módulo GPS para determinar la ubicación de esta misma. La información de la ubicación se transmitirá a la página web a través de una conexión inalámbrica.