bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of permanent and transient domain-domain interactions in multi-domain proteins
Authors: Sowdhamini Ramanathan , Sidhanta Swayam Prakash Das , Srinivasan Narayanaswamy
Published: June 2023

Protein domains are structural, functional, and evolutionary units.
These domains bring out the diversity of functionality by means of
interactions with other co-existing domains and provide stability.
Hence, it is important to study intra-protein inter-domain interactions
from the perspective of types of interactions. Domains within a chain
could interact over short timeframes or permanently, rather like
protein-protein interactions (PPIs). However, no systematic study has
been carried out between two classes, namely permanent and transient
domain-domain interactions (DDIs). In this work, we studied 264
two-domain proteins, belonging to either of these classes and their
interfaces on the basis of several factors, such as interface area and
details of interactions (number, strengths, and types of interactions).
We also characterized them based on residue conservation at the
interface, correlation of residue motions across domains, its
involvement in repeat formation, and their involvement in particular
molecular processes. Finally, we could analyse the interactions arising
from domains in two-domain monomeric proteins, and we observed
significant differences between these two classes of domain interactions
and a few similarities. This study will help to obtain a better
understanding of structure-function and folding principles of
multi-domain proteins.
“Catch-up” therapy: Combining antidotal treatment with dermal application of AHA following percutaneous VX poisoning in the domestic swine
Authors: Bloch-Shilderman Eugenia , Nili Uri , Nahum Victoria , Smolkin Boris , Ashkenazi Nissan
Published: June 2023

Low volatility organophosphorus chemical warfare agents are
cholinesterase inhibitors which rapidly absorb into the skin, leading to
the formation of a dermal depot from which they slowly enter the
bloodstream. This leads to sustained cholinergic hyperstimulation, which
if untreated may lead to death. Current available countermeasures are
not adequate to neutralize the agent residing in the dermal depot.
Herein, we evaluated the efficacy of the potassium salt of
acetohydroxamic acid (AHAK), as a potential “catch-up” therapy lotion
intended to neutralize the dermal depot by penetrating the skin and
decomposing it before it reaches the bloodstream. We compared the
clinical outcome following skin surface decontamination combined with
antidotal treatment, to that following the same antidotal treatment
combined with dermal application of AHAK at the site of VX exposure,
against percutaneous poisoning by a lethal neat dose of the low
volatility nerve agent VX, in an unanesthetized swine model. Following
skin surface decontamination and antidotal treatment, recurrence of
intoxication signs and a prolonged recovery time was observed. In
contrast, similar antidotal treatment combined with dermal application
of AHAK significantly reduced intoxication signs recurrence and
accordingly medical supervision duration needed, paralleled by a
significantly faster recovery of whole blood ChE activity. An initial
evaluation demonstrated the safety of prolonged whole-body AHAK
application. By quickly penetrating the skin at the site of exposure and
degrading the depot within it, the AHAK lotion may act as an efficient
“catch-up” therapy against percutaneous poisoning by low volatility OP
CWAs, thus improving the clinical outcome and reducing the burden on
medical staff.
Establishing A Comprehensive Workflow for Extracting MS1 Isotope Distributions in LC-MS/MS Proteomics
Authors: Vilenne Frédérique , Agten Annelies , Appeltans Simon , Ertaylan Gökhan , Valkenborg Dirk
Published: June 2023

The continuous advancements in LC-MS/MS proteomics over the past decades
have paved the way for transformative changes in the field of medicine,
particularly in the realms of preventive and personalized healthcare.
Many new algorithms are evaluated on unknown proteomes and using
databases with annotated MS2-spectra. When the research is focused on
MS1-spectra, such databases are not available yet. Specifically, we
propose a comprehensive workflow to extract MS1 isotope distributions
from spectra, which we validated using a proteomics standard kit
comprising known proteins at varying concentrations in duplicate. Our
workflow incorporated a database search utilizing a state-of-the-art
algorithm at 1% FDR. Through this approach, we investigated the impact
of protein concentration on the probability of protein identification.
Confidently identified PSMs were used to extract the MS1 isotope
distributions through the proposed workflow. A total of 138.111 MS1
isotope distributions were extracted. Isotope distributions with 2 or
more peaks were compared with their theoretical isotope distributions
using the spectral angle. A median spectral angle of 0,101 and 0,0992
was observed in both samples indicating a high similarity. The findings
from this study were compiled into a dataset which can potentially
facilitate the development of novel tools with a focus on MS1 data.
Perturbations in spike specific peripheral T follicular helper cells in SARS-CoV2 breakthrough convalescent individuals immunized by BBV152 vaccine.
Authors: Devadas Satish , Sengupta Soumya , K Shubham Shaw , Chatterjee Sanchari , Bhattacharya Gargee , K Prakash Barik , Chattopadhyay Soma
Published: June 2023

SARS-CoV2 infection has caused an increase in mortality and morbidity
but with vaccination, the disease severity has significantly reduced.
But with emergence of various variants of concerns (VOCs), the vaccine
breakthrough infection has also increased. Here, we studied circulating
spike specific T follicular response (cTfh) in infection naïve vaccinees
and convalescent vaccinees (individuals who got delta breakthrough
infection after 2 doses of BBV152 vaccine) to understand their response
as they are the most crucial cells that are involve in vaccine mediated
protection by helping in B-cell maturation. Our results indicated that
cTfh cells in both the groups recognized wild type and delta spike
protein but memory response to wild type spike was superior in infection
naïve than in convalescent group. The cytokine response particularly
IL-21 from cTfh cells was also higher in infection naïve than
convalescent vaccines indicating a dampened cTfh response in
convalescent vaccines after breakthrough infection. Also, there was
positive correlation between IL-21 from cTfh cells and neutralizing
antibodies of infection naïve vaccinees. Multiple cytokine analysis also
revealed higher inflammation in convalescent vaccinees. Our data
indicated necessity of third booster dose may be individual specific
depending in the steady state functional phenotype of immune cells.
Coastal polynyas enable transitions between high and low West Antarctic ice shelf melt rates
Authors: Moorman Ruth , Thompson Andrew F. , Wilson Earle Andre
Published: June 2023

Melt rates of West Antarctic ice shelves in the Amundsen Sea track large
decadal variations in the volume of warm water at their outlets. This
variability is generally attributed to wind-driven variations in warm
water transport towards ice shelves. Inspired by conceptual
representations of the global overturning circulation, we introduce a
simple model for the evolution of the thermocline, which caps the water
warm layer at the ice-shelf front. This model demonstrates that
interannual variations in coastal polynya buoyancy forcing can generate
large decadal-scale thermocline depth variations, even when the supply
of warm water from the shelf-break is fixed. The modeled variability
involves transitions between bistable high and low melt regimes, enabled
by feedbacks between basal melt rates and ice front stratification
strength. Our simple model captures observed variations in near-coast
thermocline depth and stratification strength, and poses an alternative
mechanism for warm water volume changes to wind-driven theories.
Aviation Turbulence Induced by the Interaction between a Jet Stream and Deep Convection
Authors: Chen Haoming , Shi Xiaoming , Leung Christy Yan-Yu , Cheung Ping , Chan Pak Wai
Published: June 2023

On December 18, 2022, Hawaiian Airlines flight HA35 encountered severe
turbulence in a cloud-free region without warning. We simulated this
incident using the Model for Prediction Across Scales (MPAS) with a
convective permitting grid. We found that the turbulence formed due to
the Kelvin-Helmholtz instability (KHI) generated by strong vertical wind
shear. At low altitudes, deep convection caused a decrease in wind speed
in both upstream and downstream regions. At upper levels, the jet
descended and accelerated after flowing over the convection, which acted
like a barrier and produced a situation similar to a downslope
windstorm. The low Scorer parameter above the jet and the self-induced
critical level created the locally enhanced descending jet stream, which
destabilized the flow through KHI.
How realistic are multi-decadal reconstructions of GRACE-like total water storage anomalies?
Authors: Hacker Charlotte , Kusche Jürgen
Published: June 2023

The Gravity Recovery and Climate Experiment (GRACE) mission has
monitored total water storage anomalies (TWSA) globally with
unprecedented resolution and accuracy since 2002. However, many
applications require a data-based, multi-decadal extended record of TWSA
prior to the GRACE period and for bridging the eleven-months gap between
GRACE and its successor GRACE Follow-On (GRACE-FO), that does not depend
on hydrological modelling. Statistical and machine-learning
‘reconstruction’ approaches have been developed to this end, mostly via
identifying relations of GRACE-derived TWSA to climate variables, and
some regional or global land data sets are now publicly available.In this contribution, we compare the two global reconstructions by
Humphrey and Gudmundsson (2019) and Li et al.(2021) mutually and against
output from the water Global Analysis and Prognosis (WaterGAP)
hydrological model from 1979 onwards, against large-scale mass-change
derived from geodetic satellite laser ranging (SLR) from 1992 onwards,
and finally against differing GRACE/-FO solutions from 2002 onwards.We find that the reconstructions agree surprisingly well in many regions
at seasonal and sub-seasonal timescales, even in the pre-GRACE era. We
find larger differences at inter-annual timescales which we speculate
are in part due to the way reconstructions are trained, and in part on
which specific GRACE solution they are trained as well as the
climatological characteristics of the region. Our comparison against
independent SLR data reveals that reconstructions (only) partially
succeed in representing anomalous TWSA for regions that are influenced
by large climate modes such as El
Ni$\tilde{\text{n}}$o-Southern
Oscillation (ENSO).
On the vertical structure and propagation of marine heatwaves in the Eastern Pacific
Authors: Köhn Eike Eduard , Vogt Meike , Münnich Matthias , Gruber Nicolas
Published: June 2023

Marine heatwaves (MHWs) have been recognized as a serious threat to
marine life, yet, most studies so far have focused on the surface only.
Here, we investigate the vertical dimension and propagation of surface
MHWs in the Eastern Pacific using results from a high-resolution
hindcast simulation (1979 to 2019), performed with the Regional Ocean
Modeling System. We detect MHWs using a seasonally varying percentile
threshold on a fixed baseline and track their vertical propagation
across the upper 500 m. We find that nearly a third (∼ 29 %) of the
MHWs extend beyond the surface mixed layer depth (MLD). On average,
these deep-reaching MHWs (dMHWs) extend to 110 m below the MLD and last
five times longer than MHWs that are confined to the mixed layer (184
vs. 36 days). The dMHWs can cause stronger temperature anomalies at
depth than at the surface (maximum intensity of 5.0°C vs. 1.9°C). This
general subsurface MHW intensification even holds when scaling the
temperatures with the respective local variability. A clustering of
dMHWs reveals that 41 % of them are block-like, i.e., continually
remain in contact with the sea surface, 24 % propagate downward, 20 %
propagate upward, while 15 % appear at the surface multiple times.
Although the water column MHW duration, intensity and severity are only
moderately correlated with their corresponding surface-based MHW
characteristics, dMHWs have the potential to be detected from the
surface. Our study can help to augment the remote sensing-based
monitoring of upper ocean exposure to MHWs.
Postfire Snow Albedo and Forest Structure Recovery Drive Decadal Watershed Scale Reductions in Snow-Water Storage and Snow Retention
Authors: Surunis Anton James , Gleason Kelly
Published: June 2023

Forest fires darken snow albedo and degrade forest structure altering
snowpack energy balance, peak snow volume and snowmelt timing for up to
15 years following burn. To date, three-dimensional volumetric estimates
of postfire effects on snow hydrology over the course of postfire
recovery have not been quantified at the watershed scale. Here we
present an improved parameterization of recovery of forest fire effects
on snow hydrology. Using a spatially-distributed snow mass and energy
balance model called SnowModel, we estimate volumetric shifts in
snow-water storage and snowmelt timing across a chrono-sequence of eight
burned forests occurring between 2000 and 2019. One to three years
following fire, postfire effects reduced peak snow-water storage by
8.42% on average (sd = 9.38%) and advanced snow disappearance date by
34 days on average (sd = 7 days). Magnitudes of snow disappearance date
advances tended to decline over recovery relative to the losses observed
immediately following fire. Postfire reductions in peak snow-water
equivalent (SWE) tended to decrease immediately following fire, and
generally recovered over 15 years postfire, but then increased again 4
to 9 years later. Postfire reductions on peak SWE summed over the
15-year postfire recovery period were up to eighteen times greater than
the losses incurred in the first winter following fire alone. Beyond 15
years following fire, postfire effects on snow persisted due to the
postfire shift from forest to open meadow.
A Drought and Heat Risk Assessment Framework for Urban Green Infrastructure
Authors: Shehayeb Raghid , Ortlepp Regine , Schanze Jochen
Published: June 2023

Urban green infrastructure (UGI) is a prominent concept towards climate
adaptation and urban resilience, but is also affected by droughts and
heat. Hence, this study aims to advance the multi-assessment of drought
and heat risks for UGI through a framework with conceptual and
methodological features, paving the way towards knowledge creation and
decision support. The framework was systematically developed, starting
with defining the situation, analyzing concepts, and finally,
constructing the framework. The situation is interpreted as a Coupled
Human and Natural System to represent the biophysical and immaterial
elements, processes and interrelations. Further, the concepts of risk,
UGI and ecosystem services come together in a risk system showing the
compound hazards, the exposure, and the cascading vulnerabilities of the
UGI. The drought and heat risk assessment framework distinguishes two
stages, multi-risk analysis, and multi-criteria risk evaluation. The
analysis includes definition and interpretation of the UGI situation
under drought and heat conditions, analyzing the hazards, exposure, and
vulnerabilities of the system, and translating the risk system into an
indicator-based information system. Hereby, the vulnerability analysis
of the biophysical UGI aspects comprises the susceptibility and
resilience of UGI entities, as well as the degree to which providing
ecosystem functions and services can be affected. The multi-criteria
risk evaluation covers the assignment of thresholds and weights for
indicators, in addition to the aggregation methods. The resulting
framework intends to support local actors in the risk assessment of
current and future conditions, fostering evidence-based decisions and
interventions to deal with risks.
Drought-flood Underlying Interactions over Global Environments
Authors: Tang Qiuhong , Haile Gebremedhin Gebremeskel
Published: June 2023

Drought and floods affect the structure, composition, and the function
of global environments and thus human societies. Although several
studies exist on both droughts and floods, studies on whether droughts
can be a means to cause floods or vice versa are lacking in the
literature. However, it has been repeatedly said that after a severe
drought season, there is heavy rainfall and thus flooding. Using
different global terrestrial ecosystems from across the globe,
understanding the underlying mechanisms, evolutions, and drivers of how
droughts can abruptly cause flooding or vice versa on a global scale
representing drought-flood hotspot regions from both the Northern and
Southern Hemispheres is indispensable. Considering drought hotspot areas
across the globe such as the 2000s Australia’s Millennium drought, and
the 2010/11 Horn of Africa drought that experienced large-scale flooding
in the aftermath of drought is crucial. Subject to analysis and
interpretations, the study findings of drought-flood underlying
interactions reveal major contributions to the growing field of drought
hydrology for future policymaking.
An ARGO and XBT observing system for the Atlantic Meridional Overturning Circulation and Meridional Heat Transport (AXMOC) at 22.5ºS
Authors: Pita Ivenis , Goes Marlos Pereira , Volkov Denis L. , Dong Shenfu , Goni Gustavo J. , Cirano Mauro
Published: June 2023

Changes in the Atlantic Meridional Overturning Circulation (AMOC) and
associated Meridional Heat Transport (MHT) can affect climate and
weather patterns, regional sea levels, and ecosystems. However, despite
its importance, direct observations of the AMOC are still limited
spatially and temporally, particularly in the South Atlantic. The main
goal of this study is to implement a cost-effective trans-basin section
to estimate for the first time the AMOC at 22.5°S, using only sustained
ocean observations. For this, an optimal mapping method that minimizes
the difference between surface in-situ dynamic height and satellite
altimetry was developed to retrieve monthly temperature and salinity
profiles from Argo and XBT data along the 22.5°S section. The mean AMOC
and MHT for 22.5°S were estimated as 15.55±2.81 Sv and 0.68±0.18 PW,
respectively, and are stronger during austral fall/winter and weaker in
spring. The high-resolution XBT data available at the western boundary
are vital for capturing the highly variable Brazil Current, and our
section shows a significant improvement when compared to Argo database.
The mean values, interannual and seasonal time series of AMOC and MHT
were compared with other products. At 22.5S the North Atlantic Deep
Water is divided into two cores that flow along both western and eastern
boundaries near 2500 m depth. Our results suggest a greater influence of
western boundary system on the AMOC variability at 22.5°S; highlight the
importance of high resolution in situ data for AMOC estimations; and
contribute for a better understanding of AMOC and MHT variability in the
South Atlantic.
On the optimization of trading on the grain market with the grain storage cost
Authors: Kociński Marek
Published: June 2023

In the article the influence of the increase in the grain storage cost on the effect of the optimization of trading on the grain market is considered. The result of the execution of the strategy of the grain purchase can be characterized for example by the sum of the expected value of the amount of money paid for the purchase of the grain and the cost of the storage of this grain. The process of the market price of the grain can be determined for example by the forecast of the grain price in the future. From the exemplary numerical calculations it follows that the storage may have a significant impact on the result of the optimization of the trading strategy on the grain market.
The Influence of Macro- and Socio-Economic Factors on the Consumption of Music throughout the Year
Authors: Woźniak Michał , Wysocki Maciej , Lis Szymon , Kijewski Mateusz
Published: June 2023

Popular research methods in assessing the impact of macroeconomic and environmental variables on music preferences were psychological experiments and surveys with small groups or analyzing the effect of one or two variables in the whole population. Instead inspired by the article of The Economist about February being the gloomiest month in terms of music listened to, we have created a dataset with many variables. We used Spotify API to create a dataset with average valence for 26 countries for the period from January 1, 2018, to December 1, 2019. Then we applied the regression and machine learning models to them. Our study confirmed the effects of summer, December, and the number of Saturdays in a month and contradicted the February effect. The influence of GDP per capita on the valence was confirmed, while the impact of the happiness index was disproved. All models partially confirmed the influence of the music genre on the valence. Among the weather variables, two models confirmed the significance of the temperature variable. Macroeconomic variables turned out to have non-linear relationships that made interpretations difficult, while the environmental ones clearly indicated a linear relationship with valence.
Insulin Sensitivity and β-Cell Function During Early and Late Pregnancy in Women With and Without Gestational Diabetes Mellitus
Authors: Mittendorfer Bettina , Patterson Bruce W. , Haire-Joshu Debra , Cahill Alison G. , Cade W. Todd , Stein Richard I. , Klein Samuel
Published: June 2023

OBJECTIVE

To evaluate the metabolic alterations associated with gestational diabetes mellitus (GDM) in women with overweight or obesity.

RESEARCH DESIGN AND METHODS

We compared fasting and postprandial plasma glucose and free fatty acid (FFA) concentrations, insulin sensitivity (IS; Matsuda index), and β-cell function (i.e., β-cell responsiveness to glucose) by using a frequently sampled oral glucose tolerance test (OGTT) at 15 and 35 weeks’ gestation in women with overweight or obesity who had GDM (n = 29) or did not have GDM (No-GDM; n = 164) at 35 weeks.

RESULTS

At 15 weeks, IS and β-cell function were lower, and fasting, 1-h, and total area-under-the-curve plasma glucose concentrations during the OGTT were higher (all P < 0.05) in the GDM than in the No-GDM group. At 35 weeks compared with 15 weeks, IS decreased, β-cell function increased, and postprandial suppression of plasma FFA was blunted in both the GDM and No-GDM groups, but the decrease in IS and the increase in postprandial FFA concentration were greater and the increase in β-cell function was less (all P ≤ 0.05) in the GDM than in the No-GDM group. A receiver operating characteristic curve analysis showed that both fasting plasma glucose and 1-h OGTT glucose concentration at 15 weeks are predictors of GDM, but the predictive power was <30%.

CONCLUSIONS

Women with overweight or obesity and GDM, compared with those without GDM, have worse IS and β-cell function early during pregnancy and a greater subsequent decline in IS and blunted increase in β-cell function. Increased fasting and 1-h OGTT plasma glucose concentration early during pregnancy are markers of increased GDM risk, albeit with weak predictive power.
Ambulatory Glucose Profile Changes During Pregnancy in Women With Type 1 Diabetes Using Intermittently Scanned Continuous Glucose Monitoring Empowered by Personalized Education
Authors: Baretić Maja , Lekšić Gloria , Ivanišević Marina
Published: June 2023

The ambulatory glucose profile is a valuable tool in managing type 1 diabetes during pregnancy. Time in range (TIR) in the third trimester is one of the most significant parameters contributing to good pregnancy outcomes. This study aimed to evaluate the effect of intermittently scanned continuous glucose monitoring (isCGM) empowered by education on glucose dynamics and to predict third trimester TIR.

Data were retrospectively analyzed from 38 pregnant patients with type 1 diabetes (mean age 30.4 ± 6.4 years, BMI 23.7 ± 3.7 kg/m2, disease duration 15.4 ± 9.5 years, preconception A1C 6.9 ± 1%) who used a first-generation FreeStyle Libre isCGM system for at least 3 months before conception and had sensor data captured >70% of the time the system was used. Patients received personalized education on diabetes and on minimizing hypoglycemia and hyperglycemia using CGM trend arrows and frequent sensor scanning.

This intervention improved glycemic parameters of glucose regulation (TIR, glucose management indicator, and mean glucose), hyperglycemia (time above range), glucose variability (SD and coefficient of variation [%CV]), and scanning frequency, but did not improve parameters of hypoglycemia (time below range and a number of low glucose events). Logistic regression analysis showed that the first trimester %CV and scanning frequency contributed to the third trimester TIR (P <0.01, adjusted R2 0.40).

This study suggests that the use of isCGM empowered by personalized education improves glycemic control in pregnant women with type 1 diabetes. Scanning frequency and %CV in the first trimester predicts TIR in the third trimester, which could help clinicians intervene early to improve outcomes.
Investigations on dross formation susceptibility in laser fusion cutting of different stainless steel compositions with emphasis on minor element effects
Authors: Mahrle A. , Wanski T. , Zeuner A. T. , Herwig P. , Zimmermann M.
Published: June 2023

The problem of variable susceptibility to dross formation or cast-to-cast variations in the performance of solid-state laser fusion cutting of 2 mm stainless steel sheets is investigated. The conducted study considered five different steel batches that each fully meets the material specifications of AISI 304 steel but show variations in minor element concentrations, particularly with respect to the sulfur content. Based on the hypothesis that the dross formation phenomenon correlates with surface tension and viscosity of the melt, the general melt flow behavior of the batches was first characterized by complementary experimental and simulative investigations. This combined approach allowed for a qualitative distinction of batches with a primary negative or positive temperature coefficient (NTC/PTC) of surface tension. Subsequent cutting experiments on qualitatively different batches with variations in cutting speed and gas pressure give evidence that an experienced wider processing window for dross-free cuts relates to PTC batches. However, these batches showed more irregular cut edge topography with slightly increased roughness values. It is consequently concluded that proper quality management in laser cutting of different batches of a material needs to consider the real composition of the materials being cut.
COGNITIVE STUDY OF APHORISMS
Authors: Anastasieva Oksana
Published: June 2023

This paper deals with the cognitive study of the conceptual field of the English language aphorism. The methodology of the cognitive analysis of the textual concepts has been proposed and applied for the study of the means of verbalization of concept WISDOM in English aphorisms. Based on the application of the proposed methodology of the cognitive study of English-language aphorisms, it can be stated that the concept WISDOM has the following constituents: 1) conceptual, the scope of which is much wider than reflected in dictionaries: «wisdom is the possession of knowledge», «wisdom is common sense», «wisdom is the ability to make spiritual sense of life», «wisdom as freedom from feelings», wisdom is sophistication», «wisdom is the heritage of the age», «wisdom is an aphorism»; 2) figurative, which is represented by figurative metaphors: «wisdom is power», «wisdom is knowledge of the truth», «wisdom is self-demanding», «wisdom is moral impeccability», «wisdom is modesty», «wisdom is freedom»; 3) valuable, represented mainly by a positive and exalted assessment.
THE IMAGE OF “AN ORDINARY AMERICAN” IN J. UPDIKE’S SHORT STORIES
Authors: Bezhan Olena
Published: June 2023

The article is devoted to the study of the short story genre in the context of the second half of the twentieth century American literature, an attempt is made to show the way of the genre from the form of standard story to so called “psychological sketch”. The short story manifested the national originality of American prose, the peculiarities of the national character and local color earlier and more fully than other forms. It developed the traditions of folk stories, folk humor, and satire. The object of analysis is J. Updike’s short story "Pigeon Feathers", that is concentrated on the middle class problems of American society and the “ordinary Americans”. Updike became an innovator in the short story genre, embodying the best ideas of his predecessors and developing his own ideas of genre diversity. According to both national and American critics, the main stylistic feature of Updike's short story collections is the close connection between them, most of them continuing each other, leaving behind a through plot and a single emotional experience.
DEVELOPMENT OF A DIGITAL EDUCATIONAL ENVIRONMENT IN CHINA
Authors: Quandeng Gou
Published: June 2023

Current model design research in the field of personalized learning mainly includes three categories: personalized learner model, personalized learning resource recommendation model, and personalized learning path model. The development of a personalized student model mainly depends on the basic information of the student, his interests and preferences, learning style, behavioral characteristics, etc.; and all learner information and data are also used to develop and implement a personalized learning resource recommendation model and an individualized learning path model Essential framework. The learner model is developed through an in-depth analysis of the learner's main attributes, learning process and learning outcomes, and on this basis, a model of the learning path that fits the learner is planned and personalized learning resources are presented. Among the various developed models, the student model occupies the largest share. In the study of personalized learning, different models can be developed that correspond to the individual characteristics and actual needs of students, so as to be more in line with the concept of respecting the individual characteristics of students, thereby contributing to the high-quality development of individualized learning and the overall development of students. We also described the model with tables that are given in the article.
PRINZIPIEN DER KONTRASTIVEN PHONOLOGISCHEN UNTERSUCHUNGEN DES UKRAINISCHEN UND DES DEUTSCHEN
Authors: Kiyko Svitlana , Kudriavtseva Olena
Published: June 2023

Inhalt des vorliegenden Beitrags ist die bestehenden Methodiken eines kontrastiven Vergleichs auf phonetisch-phonologischer Ebene zwischen zwei und mehr beliebigen Sprachen aufzulisten, ihre Vor- bzw. Nachteile für das Sprachenpaar Ukrainisch als Ausgangssprache und Deutsch als Zielsprache) zu überprüfen und eine eigene Methodik des kontrastiven Vergleichs vorzuschlagen. Uns interessieren Prinzipien der Analyse qualitativer phonologischer Unterschiede, weil gerade qualitative Gegenüberstellung für die Methodik des Fremdsprachenunterrichts unentbehrlich ist. Phonetische Abweichungen in der Aussprache der Lerner einer Fremdsprache im Sinne vom Verstoß gegen die Standardaussprache gehen in erster Linie auf den Einfluss der Muttersprache zurück. In der Regel erwirbt der Lernende das System der Zielsprache auf der Basis des Systems der Muttersprache und überträgt dieses weitgehend auf die Zielsprache, was zu zahlreichen Interferenzfehlern führt. Darum werden vor allem solche Laute nicht wahrgenommen und folglich nicht (richtig) ausgesprochen, die im System der Ausgangssprache entweder keine Entsprechung oder andere Funktionen haben oder in anderen Positionen vorkommen. Eine kontrastive Analyse auf der phonematischen Ebene soll daher in erster Linie dazu dienen, die Übereinstimmungen, Ähnlichkeiten und Divergenzen zwischen Ausgangs- und Zielsprache aufzuzeigen und somit die Möglichkeiten zu schaffen, Interferenzphänomenen in der Zielsprache kontrolliert und effektiv zu begegnen, sie durch entsprechend konzipierten Unterricht und methodisch aufbereitetes Übungsmaterial zu begrenzen oder ganz zu verhindern
THE DEVELOPMENT OF CULTURAL LITERACY AND AESTHETIC THINKING OF MUSIC TEACHERS IN CHINESE UNIVERSITIES
Authors: Meihuan Liu
Published: June 2023

This article aims to explore artistic techniques, education cognition and culture experience constitute the main system of music education. Based on numerous teaching practices of college music teachers, the development of culture literacy and aesthetic thinking are of great importance at present. Thus teaching space and application range can be extended while creation and deepening of teaching materials would be increased. This work was the result of a scientific and historical study, before which the goal was to determine the quality of musical training in China. The article shows the impact on the level of musical training of Chinese students of the latest technologies using the latest generation of multimedia technology in the process of learning to understand music better. The level of formation of professional competence characterizes the degree of preparedness of a music teacher for music-educational work at school, and acts as a prerequisite for the effectiveness of his pedagogical activity. With the development of times and the progress of society in China, the number of colleges and universities is constantly increasing. College teachers not only carry out the important task of promoting the creative traditional culture of the Chinese nation, but also must have a high degree of cultural awareness and depth. China's spiritual culture and the whole process of teaching and educating people can fulfill this mission.
ANALYSIS OF THE RISK FACTORS OF PERINATAL PATHOLOGY IN WOMEN WHO HAD COVID-19 DURING PREGNANCY
Authors: Melenchuk Lidiia
Published: June 2023

The aim of this study is to look at the impact of COVID-19 on the occurrence of perinatal complications in women who contracted COVID-19 during pregnancy, among the population of the Lviv region. Data on the results of medical and social characteristics, somatic and reproductive anamnesis, and the course of pregnancy of women who contracted COVID-19 during pregnancy (the main group) were analyzed. 20.0% of women who contracted COVID-19 during pregnancy were aged 36 years or older, while there were no women of this age in the control group (p< 0.05). The majority of pregnant women who contracted COVID-19 during pregnancy, namely 68.0% lived in the city, and the majority of healthy pregnant women in the control group lived in rural areas, namely 70.0% (p <0.05). According to social status, a significant part of the women of the main group, namely 30.0% were employed, compared to the women of the control group, where only 16.7% or (p<0.05) were employed. 24.0% of women in the main group had certain peculiarities in their reproductive anamnesis and 52.0% of them had somatic diseases. None of the women in the control group had reproductive or somatic history of complications. All women in the main group had a complicated course of pregnancy, in particular, 30.0% of women had preeclampsia, 28.0% had anemia of various degrees, 52.0% of pregnant women had combined complications, and 16.0% of women had an exacerbation of somatic pathology. In the control group, 90.0% of women did not have a complicated course of pregnancy. The majority of pregnant women (96.0%) fell ill with COVID-19 in the 3rd trimester of pregnancy, and only 4.0% of people – in the 2nd trimester. About half of the women (54.0%) had a mild course of COVID-19, 38.0% of pregnant women had a moderate course of the disease, and 8.0% had a severe course of the disease. Therefore, women over 36 years, living in an urbanized area with somatic pathology and complicated course of pregnancy can be considered as risk factors for perinatal complications for pregnant women with COVID-19.
Detection Methods of Genetically Modified Organisms (GMOS): Review
Authors: M Gidi
Published: June 2023

A living organism is considered a genetically modified organism (GMO) when a new foreign DNA segment or transgene is inserted into it to create a new trait. The field of biotechnology is currently developing at a rapid pace, with more traits and applications emerging every day. Due to concerns about the environment and living organisms, societies have not yet accepted this technology. Countries adhere to a strict biosafety protocol to reduce their fear of this issue and detect DNA and GMO protein molecules using a variety of mechanisms to ensure biotechnology products are free of foreign material or contain it at a level below the threshold, if it is present. Based on the quantity and quality of DNA and protein in these samples, these detections are made. Quantitative detection is crucial for determining the GMO threshold for each sample. The DNA-based detection of GMOs using various PCRs, either qualitatively or quantitatively is one of these detection techniques. The second most popular technique for determining how much a protein is expressed in a side organism is protein-based detection. DNA microarray, biosensors, chromatography, and DNA sequencing can all be used to find GMOs. The availability of accurate and sensitive GMO detection techniques allows us to control the presence of GMOs in crops, foods, and ingredient sources.
Hubungan Antara Kekuatan Otot Perut, Kekuatan Otot Lengan Dan Kekuatan Otot Tungkai Terhadap Kemampuan Smash Bola Voli
Authors: Adi Agasta I Made , Hidayat Syarif , Tuti Ariani Ni Luh Putu
Published: June 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara kekuatan otot perut, kekuatan otot lengan, dan kekuatan otot tungkai terhadap kemampuan smash dalam permainan bola voli. Penelitian ini merupakan penelitian korelasional dan dilakukan dengan alasan karena sebelumnya belum pernah dikaji mengenai hubungan antar variabel tersebut. Populasi dalam penelitian ini berjumlah 15 orang, dan seluruh populasi merupakan sampel penelitian. Teknik yang digunakan untuk mengumpukan data dalam penelitian ini yaitu teknik tes dan pengukuran dengan instrumen berupa tes sit-up, single hand push test, leg dynamometer tes keterampilan smash bola voli. Analisis data yang digunakan adalah uji korelasional menggunakan uji-r, dengan ketentuan apabila rhitung > rtabel maka dinyatakan bahwa kedua variabel memiliki hubungan. Hasil dari penelitian ini adalah sebagai berikut (1) terdapat hubungan antara kekuatan otot perut terhadap kemampuan smash dengan hasil r = 0.682 > r tabel = 0.514, (2) terdapat hubungan antara kekuatan otot lengan dengan kemampuan smash dengan hasil r = 0.751 > r tabel 0.514, (3) terdapat hubungan antara kekuatan otot tungkai terhadap kemampuan smash dengan hasil r = 0.824 r > r tabel = 0.514, (4) terdapat hubungan antara kekuatan otot perut, kekuatan otot lengan dan kekuatan otot tungkai terhadap kemampuan smash dengan hasil r = 0.868 > r tabel = 0.514. Berdasarkan hasil analisis data tersebut disimpulkan bahwa antar variabel tersebut memiliki korelasi.
Hubungan Antara Kekuatan Otot Tungkai Dan Koordinasi Mata-Kaki Dengan Kemampuan Shooting Sepakbola
Authors: Putu Juliarta Agus , Suratmin Suratmin , Agus Dharmadi Made
Published: June 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara kekuatan otot tungkai, koordinasi mata-kaki dengan kemampuan shooting. Ini merupakan penelitian kuantitatif dengan metode korelasi. Subjek penelitian ini adalah siswa SSB Negaroa U-15 yang berjumlah 15 orang. Instrumen yang digunakan adalah leg dynamometer test, mitchhell soccer test, dan tes keterampilan shooting sepakbola. Analisis data menggunakan uji korelasi bivariat dengan kriteria pengambilan keputusan yaitu apabila  r > r tabel maka dinyatakan terdapat hubungan antar variabel. Hasil penelitian ini adalah sebagai berikut (1) terdapat hubungan antara kekuatan otot tungkai terhadap kemampuan shooting dengan hasil r = 0.910 > r tabel = 0.514, (2) terdapat hubungan antara koordinasi mata-kaki dengan kemampuan shooting dengan hasil r = 0.930 > r tabel 0.514, (3) terdapat hubungan antara kekuatan otot tungkai, dan koordinasi mata-kaki dengan kemampuan shooting dengan hasil r = 0.940 > r tabel = 0.514 Hasil penelitian dapat disimpulkan bahwa (1) terdapat hubungan antara kekuatan otot tungkai dengan kemampuan shooting pada siswa SSB Negaroa U-15 dalam kategori kuat, (2) terdapat hubungan antara koordinasi mata-kaki dengan kemampuan shooting pada siswa SSB Negaroa U-15 dalam kategori kuat, (3) terdapat hubungan antara kekuatan otot tungkai, dan koordinasi mata-kaki dengan kemampuan shooting pada siswa SSB Negaroa U-15 dalam kategori  sangat kuat.
Motivasi Atlet Remaja Putri Dalam Mengikuti Kegiatan Pembinaan Olaharaga Bolavoli
Authors: Tasya Fahmi Alma , Suratmin Suratmin , Happy Kardiawan I Kadek
Published: June 2023

Abstrak

Penelitian ini bertujuan untuk mengetahui tingkat motivasi atlet remaja putri dalam mengikuti kegiatan pembinaan olahraga bola voli. Jenis penelitian ini adalah penelitian deskriptif. Metode yang digunakan adalah metode survey. Subyek yang digunakan dalam penelitian ini yaitu atlet remaja putri yang mengikuti kegiatan pembinaan olahraga bola voli di Tawang Alun Banyuwangi yang berjumlah 25 orang. Instrumen yang digunakan adalah observasi, kuesioner, wawancara dan dokumen. Analisis data menggunakan teknik analisis statistik deskriptif. Hasil penelitian menunjukkan bahwa tingkat motivasi atlet remaja putri yang mengikuti kegiatan pembinaan olahraga bolavoli di Tawang Alun Banyuwangi menunjukkan bahwa rata-rata nilai intrinsik motivasi atlet remaja putri sebesar 48,44, nilai simpang baku sebesar 2,93 dan total nilai skor yang dihasilkan oleh atlet sebesar 1211. Untuk nilai ektrinsik motivasi atlet remaja putri sebesar 63,44, nilai simpang baku sebesar 4,39 dan total nilai skor yang dihasilkan oleh atlet sebesar 1586. Dikarenakan X > M + 1,5 SD maka dapat disimpulkan bahwa motivasi atlet remaja putri dalam mengikuti kegiatan pembinaan olahraga bolavoli masuk kedalam kategori sangat tinggi.
sagrado feminino e a presença da Deusa em um círculo de mulheres de Fortaleza
Authors: Câmara Yls Rabelo
Published: June 2023

Este artigo – fruto de uma pesquisa básica, de abordagem qualitativa e de objetivo exploratório –, surgiu da necessidade de abordarmos a Espiritualidade feminina representada pelas danças circulares que cultuam o Sagrado Feminino. Assim, ancoramos nosso levantamento bibliográfico em Cordovil (2015), Ribeiro (2008, 2012) e Oliveira (2005), dentre outras e outros investigadores A partir dessa revisão de literatura, aliamos a teoria a um trabalho de campo de observação participante e aplicamos uma entrevista semiestruturada final às integrantes de um círculo de mulheres praticantes das danças sagradas femininas na cidade de Fortaleza, no estado brasileiro do Ceará, mulheres essas que cultuam a Deusa e reverenciam o sangue menstrual. À guisa de conclusão, acredita-se que o resultado da pesquisa em tela tem o potencial de contribuir para mostrar a importância de se estudar esse fenômeno, paralelo a tantas outras formas de expressão da Espiritualidade entre mulheres.
Koronapandemia ja mielenterveysoireilu yliopistoväellä, kyselytutkimus
Authors: Salokangas Raimo K. R. , From Tiina , Hietala Jarmo
Published: June 2023

Johdanto. Koronapandemialla on monenlaisia haitallisia vaikutuksia ihmisten mielenterveyteen. Vaikutukset riippuvat yksilökohtaisista tekijöistä
Menetelmät. Toukokuussa 2021 lähetettiin Turun yliopiston opiskelijoille ja henkilökunnalle Webropol-kysely, jossa kartoitettiin heidän masennusoireitaan ja niihin yhteydessä olevia tekijöitä korona-aikana. Kysely lähetettiin 27784 yliopistolaiselle, joista 1998 eli 7.4 % palautti hyväksytysti täytetyn lomakkeen. Yliopisto-otoksen tuloksia verrattiin vuonna 2008 toteutetun vastaavan väestökyselyn tuloksiin.
Tulokset. Alle 51-vuotiaat yliopistokyselyn tutkittavat raportoivat masennusoireita enemmän kuin vastaavan ikäiset väestökyselyn tutkittavat ennen koronapandemiaa. Iän ja työtilanteen lisäksi kontaktien määrä perheenjäseniin ja ystäviin, aktiivinen kuntoilu ja nopea toipuminen vastoinkäymisistä (resilienssi) yhdistyivät vähäisiin masennusoireisiin. Sen sijaan lapsuuden traumakokemukset yhdistyivät runsaaseen masennusoireiluun.
Pohdinta. Koronapandemialla ja sen torjuntaan liittyvillä toimenpiteillä saattoi olla yhteyttä erityisesti nuorten aikuisten lisääntyneeseen depressiiviseen oireiluun myös yliopistoyhteisössä. Pandemian torjunnassa tulee tartuntojen ehkäisyjen ohella ottaa huomioon myös toimintaohjeisiin ja rajoitustoimenpiteisiin liittyvät, väestöön kohdistuvat sosiaalipsykologiset haittavaikutukset.
Huonoon tai kohtalaiseen itsearvioituun terveydentilaan yhteydessä olevat tekijät viidesluokkalaisilla lapsilla
Authors: Kesanto-Jokipolvi Heidi , Ojala Kristiina , Koivisto Anna-Maija , Lindfors Pirjo
Published: June 2023

Itsearvioitu terveydentila on monipuolinen mittari, jossa sosiokulttuuriset tekijät yhdistyvät yksilötasoiseen kokemukseen. Monipuolisuutensa vuoksi se on tärkeä väline lasten terveysseurannassa. Suomalaisten lasten itsearvioitu terveydentila näyttää huonontuneen viime vuosina. Lisää tietoa lasten terveyskokemuksesta ja siihen yhteydessä olevista tekijöistä tarvitaan, sillä edellisiä on tutkittu verrattain vähän. Tämän tutkimuksen tavoitteena oli tunnistaa mitkä tekijät ovat yhteydessä viidesluokkalaisten lasten huonoon tai kohtalaiseen itsearvioituun terveydentilaan ja eroavatko nämä tekijät sukupuolen mukaan.
Tutkimuksen aineistona käytettiin viidesluokkalaisten (11-vuotiaat, n=959) WHO-Koululaistutkimuksen kyselyvastauksia vuodelta 2018. Logistista regressiomallia käyttämällä tutkittiin miten sosioekonominen asema, kokemus oman kehon painosta, koetut terveysongelmat, aamiaisen syöminen, päivittäinen hedelmien tai vihannesten käyttö sekä fyysinen aktiivisuus ovat yhteydessä tyttöjen ja poikien huonoon tai kohtalaiseen itsearvioituun terveydentilaan.
Oman kehon arvioiminen liian lihavaksi tai liian laihaksi oli yhteydessä huonoon tai kohtalaiseen itsearvioituun terveydentilaan kaikissa tutkituissa malleissa molemmilla sukupuolilla. Tarkasteltaessa yksittäisten tekijöiden yhteyttä huonoon tai kohtalaiseen itsearvioituun terveydentilaan havaittiin, että koettujen terveysongelmien ja viikonloppuisin syödyn aamiaisen yhdysvaikutukset olivat sukupuolen kanssa tilastollisesti merkitseviä. Huonoon tai kohtalaiseen itsearvioituun terveydentilaan yhteydessä olevat tekijät painottuivat pojilla ja tytöillä eri tavalla myös tutkittaessa usean tekijän samanaikaista yhteyttä. Pojilla korostuivat epäterveelliset ruokailutottumukset ja tytöillä itsearvioidut terveysongelmat sekä aamiaisen epäsäännöllinen syöminen viikonloppuisin.
Tutkimuksemme viidesluokkalaisten huonoon tai kohtalaiseen itsearvioituun terveydentilaan yhteydessä olevista tekijöistä antaa viitteitä sukupuolittaisten erojen varhaisesta kehittymisestä. Näiden erojen lisäksi tulisi huomioida koettuun kehon painoon liittyvä merkityksenanto jo alakouluiässä.