bluuebunny/crossref_metadata_2025 huggingface dataset:
Collective Aggressivity in Numerical cales
Authors: Suyitno Imam
Published: January 2024

The social reality of conflict (group violence) is now occurring in many spheres of our society, including students who are synonymous with educated groups and prioritize rationality in making decisions. There are several reasons why conflicts between student groups occur. Firstly, the social reality triggers the tendency for students to behave aggressively and individual conflict occurs between students, which then shifts or switches to inter-group conflicts. This is deliberately created so that actors gain sympathy, support, even assistance from members of their group. Secondly, clashes between student groups tend to increase. This is because each conflicting group has seeds of conflict symptoms which at any time give a strong contribution to student’s aggressive behavior, in the form of group prejudice, ethnocentrism, and discrimination. Lastly, when compared with the existing conflict symptoms, group prejudice ranks first in contributing to the emergence of student aggressive behavior tendencies (ry2 = 0.98 or 98%), followed by discrimination (0.96 or 96%), and ethnocentrism (0.94 or 94%).
Keywords: collective aggressivity, Universitas Negeri Makassar
NEUROLOGICAL CONSEQUENCES OF ABUSIVE USE OF ANABOLIC-ANDROGENIC STEROIDS
Authors: Gomides Lindisley , Oliveira Leandro Almeida , Mayers Nicholas , Lacerda Francielly Baêta , Santos João Pedro Belchior , Filho Brenda Borcard , Assunção Isadora Nogueira , Cupertino Marli , Santana Marcos Gonçalves
Published: January 2024

The abuse of anabolic-androgenic steroids (AASs) is associated with high morbidity and mortality rates. The highest incidence of this malpractice documented in males (prevalence rate about 6.4%), a third of which develop adverse reactions. Accordingly, the objective was to review published studies about the neurological complications triggered by the indiscriminate use of AASs, with focus on the pathogenesis of lesions in the nervous system (NS). As a result it was observed that at NS, these stimulants actuate through a complex signaling systems that include the neuroendocrine alteration of the hypothalamic-pituitary-gonadal axis, modification of neurotransmitters and their receptors, as well as the induction of neuronal death by apoptosis in several pathways. These organic neurological alterations can lead to a clinical symptomatology with neurological, mood and sleep disorders. Consequently, varying adverse effects were observed analogous to the class of AAS utilized, how it was administered and time of use. Even though to date, only a few classes were submitted for scientific analyses, on dosages, mode of administration and specific exposure times. Furthermore, the illegal use and production of these drugs does not propitiate their appropriate application, quality control and purity. It was concluded that the abuse of AAS has inimically severe and complex effects, including serious neurotoxic issues.
ARTETERAPIA E SUAS CONTRIBUIÇÕES PARA A QUALIDADE DE VIDA DAS PESSOAS
Authors: Rufato Glaucia
Published: January 2024

A Arteterapia é uma área de atuação profissional baseada principalmente nos fundamentos da arte e da psicologia, que utiliza vários tipos de expressões artísticas com uma finalidade terapêutica, que visa melhorar a saúde das pessoas e a qualidade de vida. O presente trabalho tem o objetivo de conhecer a Arteterapia e seus principais recursos artísticos, refletindo sobre os benefícios da utilização dessa prática para a saúde mental das pessoas. Essa pesquisa é de caráter bibliográfico, apoiada na revisão de literatura sobre a temática, contextualizando historicamente o surgimento da Arteterapia e seus principais fundamentos. A questão que problematiza esse estudo é: Como a utilização das manifestações artísticas utilizadas na Arteterapia contribuem para a vida das pessoas? A reflexão desenvolvida nesse trabalho nos possibilitou conhecer a Arteterapia, como ela funciona e quais seus benefícios, permitindo aos indivíduos expressarem sua subjetividade de diferentes formas. Concluímos que essa prática terapêutica é uma ferramenta importante na melhoria da saúde das pessoas, sejam elas crianças, adultos ou idosos.
PÓS-GRADUAÇÃO EM SAÚDE COLETIVA
Authors: Patricio das Graças Almeida Kayrle , Alves dos Santos Morais Paola , Guio Cavaca Aline , Pavani Lemos Ana Silvia
Published: January 2024

O trabalho objetiva refletir sobre a formação e inserção do egresso de pós-graduação em Saúde Coletiva no mercado de trabalho. Para tanto, realizou-se uma revisão integrativa da literatura, utilizando-se a estratégia PICO (população, intervenção, comparação e desfecho), elaborada em seis etapas: definição da pergunta norteadora; busca na literatura; coleta de dados; análise crítica dos estudos incluídos; discussão dos resultados; e apresentação da revisão integrativa. A busca foi realizada nas bases de dados LILACS, Scielo, CAPES, EMBASE, Pubmed, Medline e Google Acadêmico, referente ao período de 2008 a 2019. Ao final, foram selecionados seis trabalhos que respondiam à questão norteadora. Após análise crítica dos resultados, a discussão foi apresentada em três categorias analíticas: a) formação do profissional pós-graduado em Saúde Coletiva; b) Inserção dos profissionais no mercado de trabalho; c) contribuição do pós-graduado em Saúde Coletiva para o fortalecimento do Sistema Único de Saúde. Revela-se que é necessário formar pesquisadores/trabalhadores aptos a identificar problemas coerentes com as necessidades sociais em saúde, e que a compreensão da trajetória dos egressos dos cursos de pós-graduação em Saúde Coletiva é um desafio, não somente pela diversidade de projetos pedagógicos, mas também pelas múltiplas formas de inserção no mercado de trabalho.
Palavras-chave: Saúde pública, Saúde Coletiva, Mercado de trabalho, Educação de pós-graduação.
A problematização da convergência dos campos do Direito e da Saúde Coletiva
Authors: Vasconcelos Nunes José Ronaldo , Silva Jemerson de Lima , Silva Roseli Joseli da , Oliveira Carolayne Barbosa de , Silva Wendel Johnson da , Lira Anderson Diego Araújo de
Published: January 2024

O presente artigo tem o objetivo de problematizar a aproximação entre os campos de conhecimento do Direito e da Saúde Coletiva. Utilizou-se de uma revisão narrativa da literatura que permitiu a análise do objeto a partir da emergência de duas categorias que se apresentam como dicotômicas, na convergência dos dois campos, no que diz respeito às perspectivas teórica e prática. As categorias analisadas foram o Direito Sanitário e a Judicialização das questões da Saúde. O aprofundamento do debate sobre essa relação que envolve características distintas dos campos, e que tem significativa repercussão na vida social dos brasileiros que demandam políticas públicas, requer utilização de estratégias de ação tanto a partir dos sanitaristas, quanto dos agentes do Direito. A abordagem interdisciplinar se apresenta como um caminho teórico para amenizar as consequências das diferenças existentes entre os campos.
Comparative Analysis of Glycoform Profiles Between Biosimilar and Originator Monoclonal Antibodies by Liquid Chromatography–Mass Spectrometry
Authors: ATİK Ahmet Emin
Published: January 2024

Glycosylation is considered as a critical quality attribute for monoclonal antibodies (mAbs) and needs routine monitoring during production. This study aims to compare the glycoform profiles of biosimilar and four originator mAbs using ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization-quadrupole time of flight-mass spectrometry (ESI/Q-TOF MS). The resultant mass spectrum showed that seven different glycoform pairs, including G0F–GN/G0, G0F–GN/G0F, G0F/G0F, G0F/G1F, G1F/G1F, G1F/G2F, and G2F/G2F were identified via intact mass analysis for all tested mAb samples. The correct identification of each glycoform pair was achieved by comparing the observed mass with its theoretical mass using high-resolution mass spectrometry data (with mass accuracies of less than 100 ppm). The most abundant paired glycoforms detected at the intact protein level are G0F/G0F and G0F/G1F, with relative abundance ranges of 38.45 – 43.43% and 19.32 – 22.20%, respectively. The obtained data demonstrated that biosimilar and originators have the same types of glycoform pairs, and the relative abundances of each pair were comparable among biosimilar and four originator mAb samples. Additionally, the reduced mass analysis revealed that five different glycans (G0F–GN, G0, G0F, G1F, and G2F) were attached to the heavy chain of the mAb, and the relative abundance of G0F ranged from 75.21 to 77.90%. The detected mass accuracies for reduced mass analysis were below 25 ppm. The results of the intact and reduced mass analyses showed that the biosimilar is similar to its originator in terms of glycoform percentages and molecular masses.
Aquaculture Bacterial Pathogens
Authors: Ebeniro Ruth N
Published: January 2024

A significant part of Indian food production involves fisheries and aquaculture, which contribute to agricultural exports and employ around fourteen million people. Since independence, the nation has consistently increased fish production as a result of its vast aquatic resources. A total of 6.3 percent of world fish production comes from the industry, which contributes 1.1 percent to GDP and 5.15 percent to agricultural GDP. A total of 10.07 million metric tons of fish are produced in the inland sector, and around 65 percent are produced in the cultural sector. Increasing fish diseases have slowed aquaculture production and product trade in India, threatening fishermen's livelihoods. Infections can be caused by a number of factors, including low physicochemical and microbiological quality of culture water, high stocking density, and poor nutrition. It is possible for seed fish and adults to become deformed and die from exposure to pollution and suspended particles. As a result of different opportunistic bacterial infections and parasites, the fish industry suffers a significant loss in mortality and morbidity, decreased growth, and increased chemical control and prevention costs.
Ko se srečata znanje in odločanje: Pristopi k ocenjevanju varnostnih tveganj
Authors: Prislan Mihelič Kaja , Modic Maja , Lobnikar Branko , Slak Boštjan , Mihelič Anže
Published: January 2024

Ocenjevanje varnostnih tveganj predstavlja temelj strateškega upravljanja varnosti razvitih držav. V monografiji je predstavljen širok pregled različnih usmeritev in pristopov za ocenjevanje varnostnih tveganj in ogroženosti. Predstavljamo tako nacionalne strateške in zakonodajne podlage kot tudi ključne strokovne vire, mednarodne standarde in smernice. Poleg splošnih usmeritev monografija prikazuje nekatere prakse tujih držav ocenjevanja varnostnih tveganj in ogroženosti. Osrednji doprinos tega dela predstavlja predlagani model za ocenjevanje ogroženosti in tveganj na področju javne varnosti, ki je primarno namenjen organizacijam, ki delujejo na področju javne varnosti. Gre za model, ki je v svoji osnovi celovit, enovit in praktično uporaben. Model predstavlja vodilo in orodje za izvajalce (analitike) ter je zasnovan v obliki navodila, ki omogoča izvedbo ocene skozi analitično in sistematično zasnovan proces, skozi katerega se odločevalcem zagotovi ustrezna informacijska podpora za odločanje. Zaradi specifičnih pričakovanj in zahtev je model predlagan v polni in skrajšani različici
Assessment of Left Ventricle and Left Atrial Function by Speckle Tracking Echocardiography in Hypertensive Patients
Authors: Hameed Imran
Published: January 2024

Hypertension is a common clinical entity and is responsible for high cardiovascular morbidity and mortality. It affects especially the left sided chambers of the heart mainly i.e. the left ventricle and left atrium. Conventional parameters can detect the dysfunction in these chambers when it is too late. Speckle tracking echocardiography a relatively new modality but by virtue of its ease of use, angle independency and robustness can detect dysfunction at a sub-clinical stage, when effective remedies can save the patient from the deleterious effects of hypertension. In this manuscript the basics and the present clinical status of speckle tracking echocardiography in hypertensive patients have been reviewed.
Catheter Ablation of Premature Ventricular Complexes Exclusively by a Pace-Mapping Software Technique: Feasibility of a Registry Study
Authors: Sarmento Vassallo Fabricio
Published: January 2024

Introduction/Objective: Ablation of premature ventricular complexes a challenge in routine electrophysiology because results, depend on factors such as location, tools and technologies used. Aim of study was analyze exclusive use of pace-mapping technique with module of Score Map Software of Ensite Velocity/Precision and compare with success procedure, 7- and 30-days post-ablation. Methods/Results: Retrospectively analyzed 50 procedures in 47 symptomatic patients between January 2018 and February 2020. Ablation with irrigated tip catheter, power 40Watts, pump flow 30ml/min. Mapping with Duodecapolar in 40(80%) and HDGrid catheter in 10(20%). Female was 25 (53.19%), mean age 53.5years (19-78), hypertension 27 (57.45%), 7 (14.91%) coronary disease, 4 (8.51%) myocarditis, 2 (4.26%) Diabetes and 2 (4.26%) patients with an implanted defibrillator. Mean ejection fraction 63.17%. Average radiofrequency time was 580.58 seconds and mean XRay time 7.74min. Median SM was 93.92% and only 8 (16%) ablations were considered unsuccessful due to maintenance of extrasystoles or do not show a marked reduction on PVC at the end of the procedure. At 7- and 30-days follow up 9 (18%) and 7 (14%) patients had unsuccessful ablation. All patients had a Score <95%, underwent ablation with conscious sedation, majority female, most PVCs located in left ventricle and had more extensive ablation. Conclusion: Score Map is useful as exclusive technique for ablation of premature ventricular complexes with very good acute success and low complications. Score Map more than 95% had high success. Failure is related to conscious sedation, female gender, left ventricle ablation and longer radiofrequency time.
Clinical Results of Decellularized Pulmonary Allografts for Right Ventricular Outflow Tract reconstruction during Ross Procedure. Where are we today?
Authors: Dohmen Pascal M
Published: January 2024

Sir Donald N. Ross established a new era to treat aortic valve disease by introducing the Ross procedure in 1967. The original technique was complex by implanting the pulmonary valve subcoronary into the aortic root with excellent long-term results. The limited part of this specific approach however, was meanly the right ventricular outflow tract (RVOT) reconstruction. Today, the golden standard is the use of a cryopreserved pulmonary allograft, however disadvantageous such as availability and immunogenic response can eventually lead to structural valve deterioration. Tissue engineering could help to create a valve with an excellent durability including remodelling, regeneration and growth potential for RVOT reconstruction. This article reflex a recent literature overview on clinical available solutions of correcting the RVOT by the use of decellularized pulmonary allografts.
Pengaruh Kepemimpinan, Motivasi dan Disiplin Kerja Terhadap Kinerja Guru SMP Negeri di Kabupaten Minahasa Tenggara
Authors: Hosang Yudita Elvira , Handoko Yunus , K Tin Agustina
Published: January 2024

Kinerja guru sangat penting demi tercapainya tujuan pendidikan. Penelitian ini dilakukan dengan tujuan menilai pengaruh atau dampak kepemimpinan, motivasi, dan disiplin kerja terhadap kinerja guru SMP Negeri di Kabupaten Minahasa Tenggara. Metode kuantitatif digunakan dengan mengambil sampel dari 80 guru SMP Negeri dari total populasi 398 guru. Analisis regresi linear berganda dilakukan dengan SPSS 25. Hasil penelitian menunjukkan bahwa kepemimpinan tidak berpengaruh terhadap kinerja guru. Sedangkan motivasi dan disiplin kerja memiliki pengaruh positif yang signifikan terhadap kinerja guru. Temuan ini menegaskan pentingnya meningkatkan motivasi dan disiplin kerja guru untuk meningkatkan kinerja mereka di wilayah penelitian.
Transformational Leadership of Madrasah Principals in the Implementation of the Independent Curriculum
Authors: VikaSari Asri Yuni , Fauzi Anis , Bahaf Abdul Muin , Gunawan Agus , Priatna Suherman
Published: January 2024

Leaders have a key role in dealing with curriculum changes. They are responsible for identifying new needs and motivating team members through transformational leadership. This research uses qualitative methods with library research, using primary data from documents and secondary data from national/international journals with the keywords "leadership," "transformational leadership," "driving school," and "implementation of the independent curriculum." With the theoretical perspective of Bernard Bass, the author analyzes the transformational leadership of madrasa heads in implementing the independent curriculum. This article aims to describe transformational leadership through idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration. This leadership style is suitable for overcoming the challenges of changing curriculum policies because it has a positive and dynamic impact on the work environment.
FLEKSIBILITAS JAMINAN PEMBIAYAAN USAHA MIKRO PADA BMT AL-HIKMAH SEMESTA JAWA TIMUR
Authors: Ferdinand Niki Rio , Khusnudin Khusnudin
Published: January 2024

The existence of MSMEs plays a crucial role as the core of the economic growth in developing countries like Indonesia. They require ease of access to additional capital to expand their businesses. BMT Al-Hikmah Semesta Jawa Timur is one of the Islamic microfinance institutions (LKMS) that provides access to capital for micro-business operators through the flexibility of collateral in their financing products. That case is an intriguing phenomenon worth studying. The research includes examination of the forms of collateral flexibility, the risks associated with implementing this flexibility, and the goals behind its application. This study employs a qualitative approach with data collection techniques such as observation, interviews, and documentation. Based on the research findings, there are various forms of collateral flexibility, including unsecured financing, the use of non-personal collateral, flexible collateral constraints, and a quick collateral release period. However, these flexible collateral arrangements carry the risk of financing repayment failure or default. Service excellence is the ultimate objective of implementing collateral flexibility for members. This research is valuable for those who wish to delve into collateral flexibility in financing.
Implementasi Pendidikan Responsif Gender Melalui Kegiatan Funcooking pada Taman Kanak-Kanak
Authors: Azizah Farah , Afandi Nur Kholik
Published: January 2024

Penelitian ini berangkat dari problem di dalam sekolah yaitu ketimpangan jumlah siswa antara laki-laki dan perempuan yang menyebabkan terjadinya diskriminasi gender dalam setiap proses belajar dan bermain. Selain itu, anak laki-laki cenderung menkotak-kotakkan peran dalam sebuah permainan misal: bermain masak-masakan hanya untuk perempuan saja. Tujuan penelitian ini adalah untuk melihat bagaimana implementasi pendidikan responsif gender melalui kegiatan funcooking di Taman Kanak-kanak. Jenis penelitian yang di gunakan adalah jenis penelitian kualitatif dengan pendekatan studi kasus. Penelitian ini menggunakan tehnik pengumpulan data berupa observasi, wawancara dan dokumentasi. Teknik analisis data dengan model yang di terapkan Miles & Huberman dengan subjek penelitian Kepala Sekolah, guru, dan anak-anak pada Taman Kanak-Kanak di Samarinda. Hasil penelitian menunjukkan bahwa anak dapat memahami pendidikan responsif gender, memahami makna bekerjasama dalam suatu pekerjaan yang di anggap hanya sebagai pekerjaan domestik perempuan. Anak-anak di berikan kesempatan yang sama, perlakuan yang sama, bahan ajar yang sama, pelayanan yang sama dari guru tanpa membedakan gender. Pendidikan anak berbasis gender di harapkan menjadi elemen dalam pembentukan karakter dan prilaku anak ke depan.
Pengembangan Media Spinning Wheel: Media untuk Stimulasi Kemampuan Mengenal Konsep Bilangan pada Anak
Authors: Susmiarni Amelisa , Atika Nyimas , Fitri Izza
Published: January 2024

Tujuan penelitian ini adalah mengembangkan media pembelajaran spinning wheel untuk menstimulasi konsep bilangan pada anak usia dini. Penelitian ini merupakan penelitian Research and Developmen (RnD) dengan model pengembangan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Partisipan dalam penelitian ini adalah peserta didik untuk jenjang Taman Kanak-Kanak yang berada direntang usia 4-5 tahun. Untuk pengumpulan data, penelitian ini menggunakan observasi, wawancara angket dan dokumentasi serta untuk analisis data hasil lapangan menggunakan uji kevalidan, kepraktisan, dan keefektifan. Dengan analisis instrument menggunakan skala likert, didapatkan hasil validitas ahli materi 80 dengan kategori valid dan ahli media 93,33 dengan kategori sangat valid. Uji kepraktisan media spinning wheel berdasarkan angket respon guru 94 dengan kategori sangat praktis, serta angket respon peserta didik diatas 85 dengan kategori sangat efektif. Sehingga media spinning wheel dalma pengenalan konsep bilangan dinyatakan valid, praktis, dan efektif.
La gamificación en la Educación Secundaria: Estrategia Innovadora para Fomentar la Motivación de Estudiantes
Authors: Avello-Martínez Raidell
Published: January 2024

The objective of the work was to evaluate the effectiveness of the implementation of gamification with Minecraft as a pedagogical strategy in the context of the 'San Pedro de Shaglli' Educational Unit to improve student motivation. A quantitative approach was used, with a pretest-posttest experimental design with control group. The sample consisted of 25 first- and second-year high school students and eight teachers from the same institution. The questionnaire Motivational Evaluation of Instructional Materials and the Game Motivation Scale were applied. An interview was also conducted with the teachers to find out their opinion about the use of gamification and Minecraft in the classroom. The results showed that gamification with Minecraft had a positive and significant impact on some dimensions of motivation, such as confidence, satisfaction and general motivation. In addition, it was evidenced that teacher’s value positively the use of the game as a pedagogical tool, but that they require support and training to integrate it properly in the classroom. Gamification with Minecraft can be an effective strategy to improve the motivation of high school students, but it also faces some challenges that should be taken into account.
O conhecimento multidisciplinar, o trabalho como naturalista e o ativismo ambiental de Ricardo Krone [1861-1917]
Authors: Martins Carlos Eduardo
Published: January 2024

Introdução. Este artigo aborda a obra de Ricardo Krone, nascido em Dresden, Saxônia, em 1861 e falecido em Iguape, Estado de São Paulo, em 1917. Apesar das inúmeras menções a Krone em muitos estudos de diversas áreas do conhecimento, indicando que ele tinha inúmeras habilidades metodológicas e um conhecimento científico multidisciplinar, ainda não havia um estudo específico sobre ele. Objetivo. Apresentam-se ao público, de forma sistemática e contextualizada, as contribuições científicas de Ricardo Krone. Metodologia. A pesquisa é uma revisão bibliográfica de Ricardo Krone, das fontes que permitiram contextualizar a sua obra e do modelo educacional oferecido a ele em Dresden. Resultados. Krone atuou no Vale do Ribeira como naturalista para museus nacionais e internacionais, em Antropologia, Arqueologia, Cartografia, Ecologia, Etnografia, Espeleologia, Paleontologia e Ornitologia; contribuiu diretamente para a proteção legal das grutas calcárias, em 1906 e, indiretamente, na instituição do Parque Estadual e Turístico do Alto Ribeira (PETAR), em 1958. Conclusão. Ricardo Krone pesquisou diversas áreas do conhecimento, graças à formação politécnica recebida em Dresden, onde aprendeu a pensar de forma multidisciplinar e a propor soluções transversais para alcançar seus objetivos.
Industria y desarrollo: un análisis kaldoriano de la economía colombiana
Authors: Morales Martínez Daniel , Dathein Ricardo
Published: January 2024

El presente trabajo analiza la validez de las proposiciones de Kaldor en la economía colombiana entre 1976 y 2016. Se considera la industria de transformación o manufacturera como el sector clave del crecimiento económico, gracias a que presenta retornos crecientes, los cuales son más grandes que en otros sectores. Se utilizan datos de series de tiempo para producción y empleo, de varios sectores de actividad económica. Los resultados se obtienen mediante el estimador Newey-West, y de modelos autorregresivos AR(1) con procesos de Cochrane-Orcutt, Prais-Winsten y Hildreth-Lu. La evidencia encontrada es consistente con los argumentos kaldorianos y sugiere que las manufacturas tienen gran importancia en el crecimiento económico; además, presentan efectos spillover o de desbordamiento tecnológico, los cuales estimularían aumentos de productividad en otros sectores de la economía colombiana. Esto demuestra la relevancia de fomentar la producción industrial en países en desarrollo.
Estimación del PIB turístico por localidad, municipio y entidad federativa de México en 2018
Authors: Asuad-Sanén Normand Eduardo , Contreras Cleofas Omar , Mújica Romo Armando , Huitrón Mendoza José Antonio
Published: January 2024

El turismo en México es una de las actividades económicas más importantes, sin embargo, no se cuenta con datos estimados de manera rigurosa y sistemática sobre el producto interno bruto (PIB) turístico (PIBT) en escalas local, municipal y por entidad federativa, lo que no permite obtener información básica para la construcción de indicadores regionales, ni tener un conocimiento más real sobre la actividad turística subnacional en el país. De ahí que los objetivos generales de esta investigación son: 1) estimar el PIB turístico por estados y municipios para 2018 y su distribución espacial a nivel subnacional; 2) calcular el PIB turístico por localidades con base en estimaciones del PIBT municipal y estatal. Ambas estimaciones se realizan mediante análisis econométricos rigurosos a fin de dar certeza sobre su medición y presentar la distribución espacial de la actividad turística en las principales localidades, municipios y entidades federativas de México. Los resultados empíricos obtenidos consisten en datos para 2018 del pib turístico para 828 localidades, las cuales participan con 90% del pib turístico nacional (PIBTN), 644 municipios con 97% del PIBTN y 100% del PIBTN para los 32 estados de México.
Does public debt disrupt economic growth in Nigeria? A two-stage least squares approach
Authors: Duru Innocent Uchechukwu , Fortunatus Okorontah Chikeziem , Danjuma Iyaji , Nwamuo Chukwuemeka , Promise Uzoma Kelechi , Favour Ojo Toluwalashe
Published: January 2024

The impact of Nigeria's public debt on economic growth was investigated in this study. Additionally, it confirmed the validity of Nigeria's debt burden and crowding-out hypotheses. The time series data used ranged from 1981 to 2021. For analysis, the Two-Stage Least Squares and Toda Yamamoto Causality tests were employed. The findings contradicted the debt overhang effect hypothesis by showing that public debt had a positive and significant influence on economic growth. This proves that Nigeria's public debt has no adverse effects on the economic growth of the nation. Additionally, debt service has a detrimental effect on economic growth. This demonstrated that the crowding-out effect, often known as the crowding-out hypothesis, existed in Nigeria. Thus, servicing the national debt has a negative impact on Nigeria's economic expansion. The results of the public debt model, however, showed that trade openness and real gross domestic product had a favourable effect on public debt. A bidirectional relationship between public debt and economic growth was revealed by the findings of the causality test. The results also showed a one-way relationship between debt service and economic growth. As a result, the study implies that the government can simultaneously pursue its two policy goals of economic growth and public debt. Furthermore, decisions about debt repayment in Nigeria should be made in a way that promotes the growth of the economy. Nigeria should also improve institutional performance and boost its macroeconomic policy in the areas of inflation, foreign direct investment, trade, and exchange rates.
Professores de instrumento musical e suas estratégias para lidar com a motivação do aluno: um estudo guiado pela Teoria da Integração Organísmica
Authors: Figueiredo Edson
Published: January 2024

Os professores de instrumento musical, mesmo aqueles que nunca estudaram as teorias motivacionais, desenvolvem e adotam suas próprias estratégias para lidar com a motivação dos alunos. No entanto, não sabemos quais são as estratégias que os professores adotam, particularmente no contexto do ensino de instrumento musical. Diante dessa lacuna, o objetivo deste estudo foi analisar a forma como esses docentes procuram lidar com a motivação dos alunos. A análise foi conduzida sob a ótica da Teoria da Integração Organísmica, oriunda da Teoria da Autodeterminação. Inicialmente, 16 professores de uma escola de música responderam a um questionário para fornecer informações sobre seu estilo motivacional. Depois, os professores com pontuação mais alta e mais baixa foram selecionados para entrevistas e observações de aulas. Os resultados mostram que os professores utilizam estratégias baseadas em todos os estilos regulatórios simultaneamente (regulação externa, introjetada, identificada e integrada). Além disso, demonstram um discurso relativamente mais promotor de autonomia em oposição a uma atuação relativamente mais controladora. As estratégias aqui analisadas, principalmente as controladoras, podem ser um tema relevante para discutir o ensino de instrumento e elucidar as consequências motivacionais das ações dos professores.
Spatiotemporal Variability Analysis of Glaciers in the Hindukush Region of Pakistan using Remote Sensing Data
Authors: Irfan Muhammad , Shafiq Muhammad , Nergis Yasmeen
Published: January 2024

Glaciers in northern Pakistan are a prime source of fresh water, providing headwater in the Indus River System and serving as a lifeline to millions of people in the region. These glaciers undergo continuous changes by melting due to global warming or accumulation due to snowfall/precipitation at higher altitudes. In this study, we used remote sensing data to quantify glacier changes in spatiotemporal variability in the past three decades. Five glaciers in the Gilgit region (near the junction of the Hindukush and Karakoram Mountains) with an extent of less than 5 square kilometers were selected, namely Phakor glacier, Karamber glacier, East Gammu glacier, Bhort glacier, and Bad-e-Swat glacier. The fluctuations in these glaciers were monitored using a digital elevation model (DEM) and a cloud-free continuous series of Landsat satellite pictures from the minimal snow cover season. The annual climatic trends were studied through spatially interpolated gridded climate data WοrldClim version-1 climate database for 1970 – 2000. We used it to study the variations of minimum and maximum temperature, solar radiation, and precipitation by preparing sub-sets from the original global grids. The temporal assessment of Bhort, Bad-e-Sawat, East Gammu, Karamber, and other rivers was also carried out. It is observed that the glaciers in the Gilgit watershed are rather stable. The little variability of glaciers is due to their geographic condition, altitude, topography, and orientation. The mapped glacier classes have been validated to check the accuracy assessment through an error matrix method. The kappa coefficient from the error matrix has been calculated to be 84 %. The study makes a critical input to a greater understanding of watershed controlling and hydrological processes in the upper Indus catchment's Gilgit watershed.
Mammalian Cell Cytotoxicity, Antibacterial Activity, and the Properties of Methylenebis[hydroxybenzoic Acid] and Its Related zinc(II) Complex
Authors: Hussein Ahmed Ayman , Althobaiti Ibrahim O. , Aljohani Marwah , Gad Ehab S , Asiri Yazeed M. , Hussein Omar A.
Published: January 2024

Formaldehyde, sulfuric acid and salicylic acid were combined to create 3,3’-methylenebis[2-hydroxybenzoic acid] (MHB) ligand, which was subsequently permitted to bind with zinc ions. The ligand and its zinc (II) complex (Zn-MHB) have been described by a combination of elemental analyses, spectral (UV-Vis, IR, MS, NMR), XRD, TEM as well as TGA measurement. The ligand has been suggested to coordinate to the zinc center in tetradentate manner forming binuclear tetrahedral complex. An X-ray analysis indicated a considerable difference between MHB (crystalline) and Zn-MHB (amorphous). UV-Vis spectra were used to determine the optical properties such as bandgap, refractive index, optical conductivity and penetration depth. Possibility of employing the samples for optoelectronic applications was indicated from the band gap values which underlie the range of semiconductors. TEM revealed spherical shapes and mutation of ligand particles into nano-scale by complexation. The antimicrobial potential of the MHB towards gram-positive and negative bacterial growths has been investigated. The results suggested that it would be possible to employ MHB to stop bacterial development, particularly salmonella typhimurium. Cytotoxicity of the MHB was assessed against two types of mammalian cells: VERO (the kidney of an African green monkey) and HFB4 (human skin melanocytes). Lower sensitivity was observed in VERO cells.
Effects of a Novel Biostimulant Consisting of Six Bacillus sp. Strains on Growth, Yield, and Nutrient Status of Zucchini Squash
Authors: Savvas Dimitrios , Magkana Paraskevi , Yfantopoulos Dionisios , Kalozoumis Panagiotis , Ntatsi Georgia
Published: January 2024

The use of biostimulants consisting of plant growth promoting rhizobacteria (PGPR) is rapidly expanding in horticulture in recent years. In the current study, a novel mix of six Bacillus sp. strains was tested as a PGPR biostimulant in two experiments with zucchini squash (Cucurbita pepo L.) cultivated in the greenhouse soil and in an open field, respectively. In both experiments, seeds of the local landrace ‘Kompokolokytho’ and the commercial hybrid ‘ARO-800’ were either inoculated or non-inoculated with the PGPR biostimulant. The application of the six Bacillus sp. strains increased both the vegetative growth and the yield of zucchini squash, and these effects were associated with significantly higher shoot phosphorus levels in both experiments and both genotypes. Furthermore, at the end of the cultivation, the colony forming units of Bacillus sp. were appreciably higher in plants originating from inoculated compared to non-inoculated seeds, indicating that the tested mix of Bacillus sp can be successfully applied through seed inoculation. ‘ARO-800’ produced more vegetative and fruit biomass than ‘kompokolokytho’ under greenhouse cropping conditions, while in the open-field crop both genotypes performed equally, presumably because the local landrace is traditionally grown in open fields, and thus it is not well adapted to greenhouse cropping.
Phenotypic Characterization of Patients with Polycystic Ovary Syndrome in a Population from the Ecuadorian Andes: A Cross-Sectional Study
Authors: Espinosa Maria Elena , Sánchez Raul , Otzen Tamara , Bautista-Valarezo Estefanía , Aguiar Stephanie , Corrales-Gutierrez Isabel , Leon-Larios Fatima , Manterola Carlos
Published: January 2024

Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder in women of reproductive age. Diagnosis of this syndrome relies on criteria established by the Rotterdam Consensus, with PCOS phenotypes being crucial for distinguishing potential complications, treatment approaches, and timing. The aim of this study is to characterize the biodemographic, clinical, metabolic, and reproductive variables and their association with PCOS phenotypes in a population from the Ecuadorian Andes. Methodology: A cross-sectional study was conducted with a non-random consecutive sample of 92 women attending the gynecology and endocrinology outpatient clinic at the Technical University of Loja Hospital (UTPL)-Santa Inés, Loja, Ecuador, between January 2022 and July 2023.Results: The average age was 22±3.4 years, predominantly mestizo, urban, single, with higher education and a medium-high socioeconomic status. Oligo-amenorrhea and acne appear strongly associated with phenotypes A and B, while hirsutism and polycystic ovaries on ultrasound show a weaker association with these phenotypes. Alopecia is more prevalent in phenotypes C and D. Triglyceride levels and BMI have a strong association with phenotypes A and B. Total testosterone levels, 17 OH progesterone, LH, and free androgen index show a moderate association with phenotypes A and B, while other reproductive variables exhibit weak associations. Conclusions: Classical phenotypes A and B of PCOS are most common in Andean Ecuadorian women, carrying higher risks of insulin resistance, anovulation, metabolic disorders, and elevated triglycerides compared to phenotypes C and D. Ethnic diversity and sociocultural habits influence the prevalence and clinical manifestations of phenotypes.
Microstructure and Mechanical Properties of Al-Li Alloys with Different Li Contents Prepared by Selective Laser Melting
Authors: Shao Shuobing , Liang Zhuoheng , Yin Peng , Li Xingyuan , Zhang Yongzhong
Published: January 2024

Research on the development of new lightweight Al-Li alloys using selective laser melting pro-cess has great potential for industrial applications. This paper reports on the development of novel aluminum-lithium alloys using selective laser melting technology. Al-Cu-Li-Mg-Ag-Sc-Zr pre-alloyed powders with lithium contents of 1 wt.%, 2 wt.% and 3 wt.%, respectively, were prepared by inert gas atomization. After SLM process optimization, the microstructure and me-chanical properties of the as-formed specimens were investigated. The densification of the three newly developed alloys are 99.51 %, 98.96 % and 92.01 %, respectively. They all have good form-ability, with the lithium loss rate about 15 %. The as-formed alloy with 1% Li content presents good comprehensive properties with a yield strength of 412.6 ± 16.0 MPa, an ultimate tensile strength of 461.1 ± 11.7 MPa, and an elongation of 13.6 ± 1.1%. The three alloys exhibit a layered molten pool stacking morphology and have a typical heterostructure. The columnar crystals and equiaxed fine grains are alternately arranged, and most of the precipitated phases are enriched at the grain boundaries. The change of Li content mainly affects the precipitation of Cu-containing phase. When the Li content is 1 wt.%, there are θ phase, T1 phase and TB phase. When Li increased to 2 wt.%, T1 and T2 phases precipitated together. When Li reaches 3 wt.%, δ' phase precipitates with T2 phase. This study provides useful guidance for the future SLM form-ing of new crack-free and high-strength Al-Li alloys.
Comparative Study Of Spheroids (3D) And Monolayer Cultures (2D) For In Vitro Assessment Of Cytotoxicity Induced By The Mycotoxins Sterigmatocystin, Ochratoxin A And Patulin
Authors: Zingales Veronica , Esposito Maria Rosaria , Quagliata Martina , Cimetta Elisa , Ruiz María-José
Published: January 2024

Mycotoxins are secondary metabolites produced by filamentous fungi associated to a variety of acute and chronic foodborne diseases. Current toxicology studies mainly rely on monolayer cell cultures and animal models, which are undeniably affected by several limitations. To bridge the gap between the current in vitro toxicology approach and the in vivo predictivity of the data, we here investigated the cytotoxic effects induced by the mycotoxins sterigmatocystin (STE), ochratoxin A (OTA) and patulin (PAT) on different 2D and 3D cell cultures. We focused on human tumours (neuroblastoma SH-SY5Y cells, and epithelial breast cancer MDA-MB-213 cells) and healthy cells (bone marrow derived mesenchymal stem cells, BM-MSC, and umbilical vein endothelial cells, HUVECs). Cytotoxicity of STE, OTA, and PAT was determined after 24, 48 and 72 h of exposure by ATP assay in both culture models. 3D spheroids morphology was also analysed using the MATLAB-based open-source software AnaSP. Our results highlighted how each cell line and different culture models showed specific sensitivities, reinforcing the importance of using more complex models for toxicology studies and a multiple cell line approach for an improved and more comprehensive risk assessment.
Serological Antibodies Against Membrane Antigens As Potential Biomarkers of Immune Disorders
Authors: Hernandez-Suarez Leidi , Egiguren-Ortiz June , Diez-Martin Eguzkiñe , Fernández Roberto , Echevarría Aitor , Astigarraga Egoitz , Miguélez Cristina , Ramirez-Garcia Andoni , Barreda-Gomez Gabriel
Published: January 2024

Immune disorders, characterized by dysregulation at cellular and inflammatory levels, result from a complex interplay of genetics and environmental factors that lead to an abnormal immune response against autoantigens, triggering tissue damage. Recent research highlights reactive antibodies as key players in autoimmune diseases and graft rejection, but the complexity of their determination limits their use in clinic. Hence, we studied the specific binding profile of serological antibodies against a panel of cellular membranes in order to determine whether this antigenic panel could be used to diagnose specific immune disorders in humans. For this purpose, cell membrane microarrays of spleen, liver, and kidney tissues of monkey, rat, and human were developed, and human sera were analyzed, including healthy controls, patients with autoimmune disorders, and kidney transplant patients. A significant increase in antibody reactivity against specific monkey kidney and spleen membranes was observed in the serum of patients with lupus nephritis, while kidney transplant patients showed a significant enhancement against human tissues and Human embryonic kidney 293 cells. These results show the potential importance for clinical and basic research purposes of studying the presence of specific IgG against membrane antigens in the serum of patients as potential biomarkers of immune disorders.
Research on Bioethanol/Gasoline Ratios and Engine Spark Ignition Control for Energy and Environmental Sustainability of Vehicles
Authors: Rimkus Alfredas , Mejeras Gabrielius , Pukalskas Saugirdas , Nagurnas Saulius
Published: January 2024

This article presents an experimental study focused on the impact of supplementing pure gasoline (E0) with bioethanol, gradually increasing the biofuel concentration up to 70% (E10, E50, and E70). The research was conducted in two phases: In the first phase (Part I), the engine's operation involved varying engine speeds (n = 2000 rpm, n = 2500 rpm) and adjusting throttle openings (15%, 20%, 25%) to analyze changes in brake torque, thermal efficiency, and ecological indicators. The second phase (Part II) aimed to complement and clarify the study data. Here, the engine was maintained at a constant speed (n = 2000 rpm) and brake torque (MB = 80 Nm) while altering ignition timing. The findings revealed that increasing the bioethanol concentration up to 70% led to modest enhancements in engine brake torque and thermal efficiency. However, the most significant impact was observed in the reduction of greenhouse gas emissions and incomplete combustion byproducts. The study also established that achieving higher thermal efficiency requires compensating for the extended ignition delay phase resulting from bioethanol addition by advancing ignition timing. Nevertheless, this approach is constrained by the escalating emissions of carbon dioxide and hydrocarbons. These findings provide valuable insights into optimizing the balance between bioethanol supplementation, engine performance, and environmental sustainability in spark ignition engines.
Combating Antibiotic Resistance in a One Health Context: A Plethora of Frontiers
Authors: Ajose Daniel Jesuwenu , Montso Peter Kotsoana , Ateba Collins Njie , Saeed Shamsaldeen Ibrahim
Published: January 2024

Abstract: One of the most significant medical advancements of the 20th century was the discovery of antibiotics, which continue to play a vital tool in the treatment and prevention of diseases in humans and animals. However, the imprudent use of antibiotics in all fields of One-Health and concerns about antibiotic resistance among bacterial pathogens have raised interest in antibiotic use restrictions on a global scale. Despite the failure of conventional antimicrobial agents, only about 15 new antibiotics have been introduced clinically since year 2000 to date. Moreover, there have been reports of resistance to some of these new antibiotics. This has necessitated a need to search for an alternative strategy to combat antimicrobial resistant pathogens. Thus, this review compiles and evaluates the approaches—natural compounds, phage treatment, and nanomaterials—that are being used and/or suggested as the potential substitutes for conventional antibiotics. These strategies include those that focus on the enzymes or proteins, as well as the physiology and metabolism of resistant bacteria
Coefficient of Lateral Soil Pressure When Using Reinforced and Unrein-Forced Piles Filled With Sand and Granite Grains for Strengthening Road Layers
Authors: AYYAD SAMI MOHAMMED
Published: January 2024

Abstract

Several studies have been conducted to strengthen weak road layers, regardless of whether they are un-der construction or are undergoing maintenance. Using substrates filled with different materials has proven effective for increasing the strength of these layers. In this study, I evaluated the coefficient of lateral soil pressure under various conditions when using reinforced and unreinforced piles filled with in-expensive material and the extent of their contribution to strengthening road layers. The results con-firmed that there was a difference in the coefficient of lateral soil pressure when the sand-filled piles were reinforced. The sand-filled piles were divided into several parts by arming. The maximum coeffi-cient of lateral soil pressure was 0.38 in the case of sand (1 mm) with reinforcement, whereas it was 0.29 in the same case without reinforcement as shown in Figure 1. The maximum coefficient of lateral soil pressure was 0.27 in the case of granite grain (2 mm) with reinforcement, whereas it was 0.17 in the same case without reinforcement. Moreover, the maximum lateral pressure coefficient was 0.26 in the case of granite grain (3 mm) with reinforcement, and it was 0.30 in the same case without reinforce-ment.
Executive Functions in Patient with Low Degree Glioma of the Central Nervous System: Case Report
Authors: Guerrero Gómez Manuel José , Jimenez Urrego Angela María , Gonzalez Trujillo Fernando , Botero Carvajal Alejandro
Published: January 2024

Tumors of the central nervous system produce adverse outcomes in everyday life; however, low-grade gliomas are uncommon in adults. For this reason, the objective is to describe the executive function of a 59-year-old adult neuro-oncological patient. Pre- and postintervention evaluation of neurological and neuropsychological functioning was performed through neuroimaging techniques (iRM, Spectroscopy, Electroencephalography), hospital history, psychological interview, and Wisconsin Card Classification Test (WCST). Executive performance exhibited a noticeable decline in typical and centile WCST results, as evidenced by deterioration in persistent scores, failure to maintain an attitude and difficulty learning from clinical samples. This information coincides with the evolution of the neuroimage over time. Finally, this topic is discussed in the literature.