bluuebunny/crossref_metadata_2025 huggingface dataset:
Preclinical safety evaluation of Macleaya Cordata extract: A re-assessment of general toxicity and genotoxicity properties in rodents
Authors: Dong Zhen , Tang Shu-Sheng , Ma Xiao-Lan , Li Chang-Hong , Tang Zhao-Shan , Yang Zi-Hui , Zeng Jian-Guo
Published: August 2022

Macleaya cordata extract (MCE) is widely used for its diverse pharmacological actions and beneficial effects on farm animals. Modern pharmacological studies have shown that it has anti-inflammatory, anti-cancer, and anti-bacterial activities, and is gradually becoming a long-term additive veterinary drug used to improve animal intestinal health and growth performance. Although some evidence points to the DNA mutagenic potential of sanguinarine (SAN), a major component of MCE, there is a lack of sufficient basic toxicological information on the oral route, posing a potential safety risk for human consumption of food of animal origin. In this study, we assessed the acute oral toxicity, repeated 90-day oral toxicity and 180-day chronic toxicity of MCE in rats and mice and re-evaluated the genotoxicity of MCE using a standard combined in vivo and ex vivo assay. In the oral acute toxicity test, the LD50 for MCE in rats and mice was 1,564.55 mg/kg (95% confidence interval 1,386.97–1,764.95 mg/kg) and 1,024.33 mg/kg (95% confidence interval 964.27–1,087.30 mg/kg), respectively. The dose range tested had no significant effect on hematology, clinical chemistry, and histopathological findings in rodents in the long-term toxicity assessment. The results of the bacterial reverse mutation, sperm abnormality and micronucleus test showed negative results and lack of mutagenicity and teratogenicity; the results of the rat teratogenicity test showed no significant reproductive or embryotoxicity. The results indicate that MCE was safe in the dose range tested in this preclinical safety assessment. This study provides data to support the further development of maximum residue limits (MRLs) for MCE.
Linear and quadratic convection significance on the dynamics of MHD Maxwell fluid subject to stretched surface
Authors: Akbar Asia Ali , Awan Aziz Ullah , Bani-Fwaz Mutasem Z. , Tag-ElDin ElSayed M. , Guedri Kamel , Yassen Mansour F. , Ali Bagh
Published: August 2022

The heat transmission process is a prominent issue in current technology. It occurs when there is a temperature variation between physical processes. It has several uses in advanced industry and engineering, including power generation and nuclear reactor cooling. This study addresses Maxwell fluid’s steady, two-dimensional boundary layer stream across a linearly stretched sheet. The primary objective of this research is to investigate the impact of the non-Newtonian fluid parameter (Deborah number) on flow behavior. The secondary objective is to investigate the effect of linear and quadratic convection to check which model gives higher heat transfer. The flow is caused by the surface stretching. The mathematical model containing the underlying partial differential equations (PDEs) is built using the boundary layer estimations. The governing boundary layer equations are modified to a set of nonlinear ordinary differential equations (ODEs) using similarity variables. The bvp4c approach is employed to tackle the transformed system mathematically. The impacts of numerous physical parameters like stretching coefficient, mixed convective parameter, heat source/sink coefficient, magnetic coefficient, variable thermal conductance, Prandtl number, and Deborah number over the dimensionless velocity and temperature curves are analyzed via graphs and calculated via tables. After confirming the similarity of the present findings with several earlier studies, a great symmetry is shown. The findings show that the linear convection model gains more heat transport rate than the quadratic convection model, ultimately giving a larger thermal boundary layer thickness. Some numeric impacts illustrate that boosting the magnetic coefficient elevates the fluid’s boundary layer motion, causing an opposite phenomenon of Lorentz force because the free stream velocity exceeds the stretched surface velocity.
miR-3064-5p and miR-4745-5p affect heparin sensitivity in patients undergoing cardiac surgery by regulating AT-III and factor X mRNA levels
Authors: Ma Hai-Ping , Fu Min , Masula Maisitanguli , Xing Chang-Shuang , Zhou Qiang , Tan Jing-Tong , Wang Jiang
Published: August 2022

Subject: Perioperative regulation of coagulation function through heparin in patients undergoing cardiac surgery with cardiopulmonary bypass is an important part of performing cardiac surgery, and postoperative bleeding due to abnormal coagulation function caused by differences in heparin sensitivity in different individuals is an independent risk factor for postoperative complications and death.

Method: Using an online database, 10 miRNAs interacting with AT-III and FX genes were predicted. Patients were divided into three groups according to the difference in activated clotting time (ACT) after the first dose of heparin (2.5 mg kg−1): group A: hyposensitive group (ACT < 480 s); group B: sensitive group (480 s ≤ ACT ≤ 760 s); and group C: hypersensitive group (ACT > 760 s). Perioperative and 24 h postoperative blood loss and other clinical data of patients in the three groups were recorded. Blood samples were collected before surgery, and RT-PCR was used to detect the levels of AT-III and FX gene mRNA and the levels of predicted 10 miRNAs.

Result: Heparin sensitivity was positively correlated with AT-III mRNA levels and negatively correlated with FX gene mRNA levels in the three groups, and the blood loss in group B was significantly lower than that in groups A and C, which was statistically significant (p < 0.05). miR-3064-5p and miR-4745-5p expression levels were significantly different among group A, group B, and group C (p < 0.05) and were closely correlated with AT-III and FX gene mRNA expression levels, respectively.

Conclusion: Differences in heparin sensitivity in patients undergoing cardiac surgery were associated with the mRNA expression of AT-III and FX genes, and the expression levels of miR-3064-5p and miR-4745-5p were found to be closely related to the AT-III and FX gene mRNA, respectively, indicating that miR-3064-5p and miR-4745-5p affect the differences in heparin sensitivity among different individuals by regulating the mRNA expression levels of AT-III and FX genes.

Clinical Trial Registration:http://www.chictr.org.cn/abouten.aspx, identifier registration number: ChiCTR-2100047348
Functional brain imaging and central control of the bladder in health and disease
Authors: Pang Dongqing , Gao Yi , Liao Limin
Published: August 2022

Central control of the bladder is a complex process. With the development of functional imaging technology and analysis methods, research on brain-bladder control has become more in-depth. Here, we review previous functional imaging studies and combine our latest findings to discuss brain regions related to bladder control, interactions between these regions, and brain networks, as well as changes in brain function in diseases such as urgency urinary incontinence, idiopathic overactive bladder, interstitial cystitis/bladder pain syndrome, urologic chronic pain syndrome, neurogenic overactive bladder, and nocturnal enuresis. Implicated brain regions include the pons, periaqueductal grey, thalamus, insula, prefrontal cortex, cingulate cortex, supplementary motor area, cerebellum, hypothalamus, basal ganglia, amygdala, and hippocampus. Because the brain is a complex information transmission and processing system, these regions do not work in isolation but through functional connections to form a number of subnetworks to achieve bladder control. In summarizing previous studies, we found changes in the brain functional connectivity networks related to bladder control in healthy subjects and patients involving the attentional network, central executive network or frontoparietal network, salience network, interoceptive network, default mode network, sensorimotor network, visual network, basal ganglia network, subcortical network, cerebella, and brainstem. We extend the working model proposed by Griffiths et al. from the brain network level, providing insights for current and future bladder-control research.
Iron dyshomeostasis and time-course changes in iron-uptake systems and ferritin level in relation to pro-inflammatory microglia polarization in sepsis-induced encephalopathy
Authors: Sharawy Nivin , Imam Ahmad Abdel-Aliem , Aboulhoda Basma Emad , Khalifa Mohamed Mansour , Morcos George N. B. , Abd Algaleel Waleed Ahmed , Moustafa Passant E. , Abdelbaset Marwan A. , Shoukry Tarek
Published: August 2022

Encephalopathy is a frequent and lethal consequence of sepsis. Recently, a growing body of evidence has provided important insights into the role of iron dyshomeostasis in the context of inflammation. The molecular mechanisms underlying iron dyshomeostasis and its relationship with macrophage phenotypes are largely unknown. Here, we aimed to characterize the changes in iron-transporter and storage proteins and the microglia phenotype that occur during the course of sepsis, as well as their relationship with sepsis-induced encephalopathy. We used a cecal ligation and puncture (CLP) murine model that closely resembles sepsis-induced encephalopathy. Rats were subjected to CLP or sham laparotomy, then were neurologically assessed at 6 h, 24 h, and 3 days after sepsis induction. The serum and brain were collected for subsequent biochemical, histological, and immunohistochemical assessment. Here, an iron excess was observed at time points that followed the pro-inflammatory macrophage polarization in CLP-induced encephalopathy. Our results revealed that the upregulation of non-transferrin-bound iron uptake (NTBI) and ferritin reduction appeared to be partially responsible for the excess free iron detected within the brain tissues. We further demonstrated that the microglia were shifted toward the pro-inflammatory phenotype, leading to persistent neuro-inflammation and neuronal damage after CLP. Taken together, these findings led us to conclude that sepsis increased the susceptibility of the brain to the iron burden via the upregulation of NTBI and the reduction of ferritin, which was concomitantly and correlatively associated with dominance of pro-inflammatory microglia and could explain the neurological dysfunction observed during sepsis.
Genome-wide investigation of AP2/ERF gene family in the desert legume Eremosparton songoricum: Identification, classification, evolution, and expression profiling under drought stress
Authors: Zhao Mingqi , Haxim Yakupjan , Liang Yuqing , Qiao Siqi , Gao Bei , Zhang Daoyuan , Li Xiaoshuang
Published: August 2022

Eremosparton songoricum (Litv.) Vass. is a rare leafless legume shrub endemic to central Asia which grows on bare sand. It shows extreme drought tolerance and is being developed as a model organism for investigating morphological, physiological, and molecular adaptations to harsh desert environments. APETALA2/Ethylene Responsive Factor (AP2/ERF) is a large plant transcription factor family that plays important roles in plant responses to various biotic and abiotic stresses and has been extensively studied in several plants. However, our knowledge on the AP2/ERF family in legume species is limited, and no respective study was conducted so far on the desert shrubby legume E. songoricum. Here, 153 AP2/ERF genes were identified based on the E. songoricum genome data. EsAP2/ERFs covered AP2 (24 genes), DREB (59 genes), ERF (68 genes), and Soloist (2 genes) subfamilies, and lacked canonical RAV subfamily genes based on the widely used classification method. The DREB and ERF subfamilies were further divided into A1–A6 and B1–B6 groups, respectively. Protein motifs and exon-intron structures of EsAP2/ERFs were also examined, which matched the subfamily/group classification. Cis-acting element analysis suggested that EsAP2/ERF genes shared many stress- and hormone-related cis-regulatory elements. Moreover, the gene numbers and the ratio of each subfamily and the intron-exon structures were systematically compared with other model plants ranging from algae to angiosperms, including ten legumes. Our results supported the view that AP2 and ERF evolved early and already existed in algae, whereas RAV and DREB began to appear in moss species. Almost all plant AP2 and Soloist genes contained introns, whereas most DREB and ERF genes did not. The majority of EsAP2/ERFs were induced by drought stress based on RNA-seq data, EsDREBs were highly induced and had the largest number of differentially expressed genes in response to drought. Eight out of twelve representative EsAP2/ERFs were significantly up-regulated as assessed by RT-qPCR. This study provides detailed insights into the classification, gene structure, motifs, chromosome distribution, and gene expression of AP2/ERF genes in E. songoricum and lays a foundation for better understanding of drought stress tolerance mechanisms in legume plants. Moreover, candidate genes for drought-resistant plant breeding are proposed.
Variations of rhizosphere and bulk soil microbial community in successive planting of Chinese fir (Cunninghamia lanceolata)
Authors: Chen Jiachen , Deng Zhifang , Jiang Zheng , Sun Jin , Meng Fangfang , Zuo Xiaodong , Wu Linkun , Cao Guangqiu , Cao Shijiang
Published: August 2022

Successive planting and monoculture, as common forest management methods, are widely used globally, especially in Chinese fir plantations in the subtropical areas of southern China. Although soil fertility depletion and productivity decline caused by successive planting have been widely reported, the underlying mechanism is still ambiguous. In this study, the composition and diversity of soil microorganisms (rhizosphere and bulk soils) in Chinese fir seedlings exposed to successive planting soils (first-generation Chinese fir seedings, FCP. second-generation Chinese fir seedings, SCP. third-generation Chinese fir seedings, TCP) and broadleaf tree species soil (Phoebe zhennan S. Lee et F. N. Wei, CK) were examined with high-throughput sequencing technology. Our findings revealed that the diversity and richness of bacterial and fungal communities were remarkably reduced in TCP than FCP and SCP, and were remarkably different between FCP and SCP. At the phylum level, the fungi with greatest relative abundance were Basidiomycota (5.74–32.88%) and Ascomycota (57.63–87.38%), while the bacteria with the greatest relative abundance were Acidobacteria (23.16–31.17%) and Proteobacteria (24.71–29.32%) for all treatments in both soil types. Additionally, the relative abundance of some pathogens (Penicillium and Burkholderia) was significantly higher in TCP than in FCP and SCP, suggesting that the presence of pathogens is an important factor in increasing the incidence of soil-borne sickness. Moreover, changes in fungal and bacterial communities were predominantly driven by soil dissolved organic carbon (DOC), DOC/DON ratio (DOCN), NO3–-N, microbial biomass carbon (MBC), and MBC/MBN ratio (MBCN). Overall, the long-term monoculture of Chinese fir promotes the microecological imbalance of rhizosphere and bulk soil, and remarkably reduced soil microbial community diversity. These results can provide a scientific support for the implementation of future management measures for fir plantations (e.g., fertilization, addition of microbial fungicides, and construction of mixed forests).
The psychological and cognitive factors causing college students’ demotivation to learn English in China
Authors: Ren Xiaobin , Abhakorn Jirapa
Published: August 2022

Demotivation is one of the important factors causing students’ failure in learning a language. To explore the psychological and cognitive factors causing college students’ demotivation to learn English in China’s universities and to investigate the relations among these internal factors, this study constructed a shopping cart model by applying grounded theory method and tested the model by using structural equation modeling. This study found three paths underlying students’ demotivation to learn English, originating from large discrepancy between students’ actual and required positioning of English learning, low required positioning of English learning and low value of English learning in students’ minds. Based on these findings, this study gave some pedagogical implications for English teaching.
Effect of skill proficiency on motor imagery ability between amateur dancers and non-dancers
Authors: Mao Xiaoling , Huang Shaoxu , Ouyang Mingkun , Xie Yangqiu , Tan Xinhua
Published: August 2022

Evidence has shown that athletes with high motor skill proficiency possess higher motor imagery ability than those with low motor skill proficiency. However, less is known whether this superiority in motor imagery ability emerges over amateur athletes. To address the issue, the present study aimed to investigate the individual differences in motor imagery ability between amateur dancers and non-dancers. Forty participants completed a novel dance movement reproduction task and measures of the vividness of visual imagery questionnaire (VVIQ) and the vividness of motor imagery questionnaire (VMIQ). The results showed that, relative to non-dancers, amateur dancers had higher ability of motor imagery to reproduce the lower-limb and upper-limb dance movements during the dance movement reproduction task. Besides, amateur dancers displayed higher abilities of the visual motor imagery and the kinesthetic imagery, but comparable visual imagery ability as the non-dancers. These findings suggest that the mental representation of motors but not the visual is affected by the motor skill levels, due to the motor imagery practice in sports amateurs.
Effects of homework creativity on academic achievement and creativity disposition: Evidence from comparisons with homework time and completion based on two independent Chinese samples
Authors: Fan Huiyong , Ma Yidan , Xu Jianzhong , Chang Ying , Guo Shengli
Published: August 2022

During the past several decades, the previous studies have been focusing on the related theoretical issues and measuring tool of homework behaviors (mainly including homework time, completion, and homework creativity). However, the effects of these homework behaviors on general creativity remain unknown. Employing a number of questionnaires, this study investigated two samples from middle schools of Mainland China. The results showed that (1) the eight-item version of Homework Creativity Behaviors Scale had acceptable validity and reliability; (2) compared with homework completion and homework time, homework creativity explained less variety of academic achievement (3.7% for homework creativity; 5.4% for completion and time); (3) homework creativity explained more variance of general creativity than that of homework completion and homework time accounted (7.0% for homework creativity; 1.3% for completion and time); and (4) homework creativity was negatively associated with grade level. Contrary to the popular beliefs, homework completion and homework creativity have positive effects on the students’ general creativity. Several issues that need further studies were also discussed.
Financial well-being: Capturing an elusive construct with an optimized measure
Authors: Aubrey Marc , Morin Alexandre J. S. , Fernet Claude , Carbonneau Noémie
Published: August 2022

Several definitions and measures of financial well-being (FWB) have been proposed in the scientific literature. The Multidimensional Subjective Financial Well-being Scale (MSFWBS) stands out among these measures in its ability to account for the conceptual richness of FWB. However, the original validation study based on a confirmatory factor analytic model indicated that the factor structure of scores obtained on this instrument was acceptable at best, revealing factor correlations high enough to question the discriminant validity of the factors. To improve conceptual and operational clarity of FWB, this study assesses the psychometric properties of the MSFWBS among French-Canadian adults (n = 454), using statistical models better suited to the examination of multidimensional constructs (exploratory structural equation modeling—ESEM, and bifactor-ESEM). Our results supported a bifactor-ESEM representation of scores on the MSFWBS, and their measurement invariance across groups of participants defined on the basis of their age, sex, personal income and household income. Our results also supported the convergent (with other measures of FWB) and criterion-related (with measures of life satisfaction, perceived stress, and psychological distress) validity of scores obtained on the MSFWBS (particularly the global FWB factor). By providing an optimized measure of FWB, our study contributes to advancing research on FWB.
Is exercise/physical activity effective at reducing symptoms of post-traumatic stress disorder in adults — A systematic review
Authors: Jadhakhan Ferozkhan , Lambert Nichola , Middlebrook Nicola , Evans David W. , Falla Deborah
Published: August 2022

Background

Exercise has been used to manage symptoms of post-traumatic stress disorder (PTSD). The effect of exercise on PTSD outcomes has been previously explored in several studies. However, it still remains unclear what type of exercise/physical activity, intensity and duration is most effective for reducing symptoms of PTSD. A systematic review was conducted to determine which forms of exercise or physical activity have the greatest effect on PTSD outcome scores including an evaluation of exercise frequency and volume.

Methods

The following electronic databases were systematically searched from January 1980 to June 2021: MEDLINE, PsycINFO, PubMed and Web of Science. Inclusion criteria were studies investigating adults aged 18 or over, reporting the effect of exercise and physical activities on PTSD symptom outcome scores. Two reviewers independently extracted information on study characteristics, exposure and outcomes. In total of 3,217 articles were screened and 23 full text articles further assessed, with 13 RCT's included in the review, covering seven exercise/physical activity interventions. The study protocol was registered prospectively with PROSPERO (CRD42021255131).

Results

Thirteen studies from four countries involving a total of 531 patients were selected for inclusion. Individual forms of exercise/physical activity examined showed some effect on reducing PTSD symptoms but combined exercises (resistance training, aerobic, strength and yoga) administered over a 12 week period, three times a week for 30–60 min showed greater effects on PTSD symptoms.

Conclusion

The limited evidence suggests that a combined exercise intervention has the best evidence for a having a beneficial effect on PTSD symptoms.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=255131.
Prosocial priming and bystander effect in an online context
Authors: Scaffidi Abbate Costanza , Misuraca Raffaella , Vaccaro Chiara , Roccella Michele , Vetri Luigi , Miceli Silvana
Published: August 2022

The present study tested the effect of priming the concept of prosociality on the bystander effect in an online environment. Participants were sent an e-mail requesting a plea for help and randomly assigned to one of four conditions in a 2 (Bystander: 0 vs. 14) × 2 (Priming: present vs. absent) design. The results demonstrated support for the study hypothesis. As expected, the virtual presence of many others significantly reduced e-mail responsiveness except when the request for help is preceded by prosocial priming. Implications of these findings for the literature on the bystander effect and priming are discussed.
Efficacy of Smartphone Apps in Patients With Depressive Disorders: A Systematic Review
Authors: Hernández-Gómez Alba , Valdés-Florido María José , Lahera Guillermo , Andrade-González Nelson
Published: August 2022

Background

Digital interventions have become an accessible format in clinical practice to provide better support for patients with mental disorders. However, the clinical efficacy in patients with depressive disorders is not well known. We aimed to determine the efficacy of smartphone applications (apps) in patients diagnosed with a depressive disorder.

Method

An electronic database search was performed of PubMed, PsycINFO, and Web of Science, to identify relevant articles up to June 12, 2021. Peer-reviewed articles were screened and selected based on predetermined inclusion and exclusion criteria.

Results

Seven articles met the inclusion criteria and therefore were selected for the systematic review, which included a total of 651 patients. The results were heterogeneous, essentially due to the different methodologies used in the selected studies.

Conclusions

Digital smartphone-delivered interventions do not appear to reduce depressive symptomatology nor improve the quality of life in patients diagnosed with depressive disorders when compared to an active control group. Taking into account the inherent methodological difficulties and the variability among such studies, it is apparent that further research—with more methodologically refined clinical trials, including larger sample sizes—is needed.
Public stigma profile toward mental disorders across different university degrees in the University of Valencia (Spain)
Authors: Ruiz Juan C. , Fuentes-Durá Inmaculada , López-Gilberte Marta , Dasí Carmen , Pardo-García Cristina , Fuentes-Durán María C. , Pérez-González Francisco , Salmeron Ladislao , Soldevila-Matías Pau , Vila-Francés Joan , Balanza-Martínez Vicent
Published: August 2022

Background

A large proportion of studies carried out in recent years in different populations have shown that stigma toward mental disorders is highly prevalent. In the present study we conducted a comprehensive assessment of stigma to describe and compare stigma toward mental disorders in students enrolled in five different university degrees.

Methods

Three hundred and twenty-five students from the University of Valencia (Spain), attending the second term of their first-degree courses in the faculties of medicine, psychology, teaching, economics, and data science participated in this cross-sectional study. Stigma was measured using: the Reported and Intended Behavior Scale (RIBS), the Scale of Community Attitudes toward Mental Illness (CAMI), the Attribution Questionnaire (AQ-27), and the Knowledge about Mental Illness test (KMI).

Results

We found different patterns of stigma according to gender, the fact of knowing or living with a person with mental disorders and the university degree studied. Overall, women show fewer stigmatizing attitudes than men but similar stereotypes and prejudice toward people with mental disorders. However, the pattern of results across degrees is more complex. Overall, students of medicine, psychology and teaching showed fewer stigmatizing attitudes than students of economics and data science but differences between degrees were more subtle in stereotypes and prejudice toward people with mental disorders.

Conclusion

Our study suggests the existence of different profiles of stigma in relation to mental disorders in university students. These profiles varied in relation with the degree being studied, gender and already knowing or living with a person with mental disorders.
Subgroup detection-based dental caries status and inequalities trend exploration: A nationwide, 10-year-repeated cross-sectional study
Authors: He Jie , Liang Hongyuan , Kang Jian , Yuan Chao
Published: August 2022

Background

The goal of this study was to identify potentially important factors for the dental health though heterogeneous effects of risk factors within Chinese adolescent populations with different characteristics by analyzing the repeated cross-sectional data collected in the 3rd (2005) and 4th (2015) National Oral Health Survey.

Methods

We studied the relationships between the decayed, missing and filled permanent teeth (DMFT) score, which was a discrete value, with the caries risk factors (region, census type, gender, only child or not, parents' education level, tooth bushing, dentist visit history, knowledge score, sugar intake, and pit-and-fissure sealants status), though the Poisson mixture regression model, which could identify subgroups among the full population and estimate the heterogeneous effects of risk factors simultaneously. We performed a series of tests and trend analysis based on the model fitting results to explore the primary causes for the dental caries issue clearly and intuitively.

Results

A total of 39,049 teenagers aged 12 years were involved in the analysis. The Poisson mixture regression model clustered all individuals into three subgroups, where the mean values (standard deviations) of DMFT were 0.18 (0.56), 1.31 (1.49), and 2.91 (1.89), respectively. Model fitting results indicated that the heterogeneous effects of the involved risk factors were significant. In addition, we also found significant differences in the distributions and trends of DMFT within different categories of selected risk factors (region, census type, gender and dentist visiting history) from the projection analysis results. The estimated and projected proportions showed that the proportion of high caries risk population in the southwestern region increased by 31.8%, and will become even more severe as it will be the major component of high caries risk population in 2025.

Conclusions

We found that the trends for the developments and changes of dental caries within populations with different characteristics were inequality. The regional difference is the primary factor for diversified changes in DMFT. The findings in this study provide support for intervention and prevention policies for the deterioration of dental caries risk within different adolescent populations.
COVID-19 triggered a physically active lifestyle of people with cardiovascular diseases: Results of a small Austrian qualitative study
Authors: Krczal Eva , Hyll Walter
Published: August 2022

Objective

This paper explores physical activity patterns and compensation strategies of people with cardiovascular diseases. The aim is to provide insights into the factors and their relationships that may affect physical activity levels positively or negatively during the pandemic.

Methods

We adopted a qualitative approach with 35 participants who were purposively sampled from different provinces in Austria, including rural and urban areas. Semi-structured interviews were conducted during the second COVID-19 wave in autumn/winter 2020 and the fourth wave in autumn/winter 2021. Content analysis was applied to explore physical activity patterns, the perceived impact of the pandemic on physical activity as well as strategies adopted by participants to maintain physically active during the pandemic waves.

Results

Results show encouraging signs of a recovery or even increase in physical activity during the pandemic waves. The main drivers for maintaining or even increasing physical activity were intrinsic motivation and self-determined motivation relating to the pursue of individual health goals. Furthermore, analysis suggests a reinforcing effect of exercising in green natural areas by decreasing perception of effort and increasing motivation. There was also one group who experienced difficulties in adapting physical activity behaviors. Study participants who were used to exercise indoors struggled to replace accustomed activity patterns with alternatives that were not impacted by lockdown restrictions.

Conclusions

This study provides novel qualitative evidence on the effect of COVID-19 lockdowns on physical activity patterns of people with cardiovascular diseases. Public health interventions to enhance a physically active lifestyle during and beyond the COVID-19 pandemic are recommended to target moderate outdoor exercising and enhance adaptive capacities of people with cardiovascular diseases.
Psychological health in COVID-19 patients after discharge from an intensive care unit
Authors: Carola Valeria , Vincenzo Cristina , Morale Chiara , Pelli Massimiliano , Rocco Monica , Nicolais Giampaolo
Published: August 2022

Along with physical changes, psychological changes are detectable in patients with COVID-19. In these patients, the stressful experience of intensive care unit (ICU) hospitalization may aggravate psychological conditions. Our study examines the short- and long-term psychological consequences of COVID-19 in ICU patients. COVID-19 patients completed the self-rating questionnaires Kessler 10 Psychological Distress Scale (K10), Perceived Stress Scale-10 (PSS), Impact of Event Scale Revised (IES-R), and Post-traumatic Growth Inventory (PTGI) and were clinically interviewed 1 and 6 months after discharge. Altered behavioral-psychological symptoms and patients' strategies (adaptive vs. maladaptive) for coping with stress during and after hospitalization were coded during clinical interviews. Between 20 and 30% of patients showed moderate symptoms of depression or anxiety and perceived stress 1 and 6 months after discharge. Sleep problems, difficulty concentrating, confusion in placing events, and fear of reinfection were observed in many (6–17%) patients. At 6 months, only 7% of patients showed PTSD symptoms, and 50% showed post-traumatic growth in the “appreciation of life” sub-scale. Finally, 32% of subjects were classified as “maladaptive coping patients,” and 68% as “adaptive coping patients.” Patients who adopted “adaptive” coping strategies showed significantly lower levels of anxious-depressive symptoms and perceived stress when compared to subjects with “maladaptive” strategies at both time points. Coping strategy had no effect on PTSD symptoms or post-traumatic growth at 6 months. These findings clarify the short- and long-term psychological effects of intensive care due to COVID-19 infection and demonstrate that patient characteristics, particularly strategies for coping with stress, seem to play a critical role in psychological outcomes.
Development and comparison of predictive models for sexually transmitted diseases—AIDS, gonorrhea, and syphilis in China, 2011–2021
Authors: Zhu Zhixin , Zhu Xiaoxia , Zhan Yancen , Gu Lanfang , Chen Liang , Li Xiuyang
Published: August 2022

Background

Accurate incidence prediction of sexually transmitted diseases (STDs) is critical for early prevention and better government strategic planning. In this paper, four different forecasting models were presented to predict the incidence of AIDS, gonorrhea, and syphilis.

Methods

The annual percentage changes in the incidence of AIDS, gonorrhea, and syphilis were estimated by using joinpoint regression. The performance of four methods, namely, the autoregressive integrated moving average (ARIMA) model, Elman neural network (ERNN) model, ARIMA-ERNN hybrid model and long short-term memory (LSTM) model, were assessed and compared. For 1-year prediction, the collected data from 2011 to 2020 were used for modeling to predict the incidence in 2021. For 5-year prediction, the collected data from 2011 to 2016 were used for modeling to predict the incidence from 2017 to 2021. The performance was evaluated based on four indices: mean square error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE).

Results

The morbidities of AIDS and syphilis are on the rise, and the morbidity of gonorrhea has declined in recent years. The optimal ARIMA models were determined: ARIMA(2,1,2)(0,1,1)12, ARIMA(1,1,2)(0,1,2)12, and ARIMA(3,1,2)(1,1,2)12 for AIDS, gonorrhea, and syphilis 1-year prediction, respectively; ARIMA (2,1,2)(0,1,1)12, ARIMA(1,1,2)(0,1,2)12, and ARIMA(2,1,1)(0,1,0)12 for AIDS, gonorrhea and syphilis 5-year prediction, respectively. For 1-year prediction, the MAPEs of ARIMA, ERNN, ARIMA-ERNN, and LSTM for AIDS are 23.26, 20.24, 18.34, and 18.63, respectively; For gonorrhea, the MAPEs are 19.44, 18.03, 17.77, and 5.09, respectively; For syphilis, the MAPEs are 9.80, 9.55, 8.67, and 5.79, respectively. For 5-year prediction, the MAPEs of ARIMA, ERNN, ARIMA-ERNN, and LSTM for AIDS are 12.86, 23.54, 14.74, and 25.43, respectively; For gonorrhea, the MAPEs are 17.07, 17.95, 16.46, and 15.13, respectively; For syphilis, the MAPEs are 21.88, 24.00, 20.18 and 11.20, respectively. In general, the performance ranking of the four models from high to low is LSTM, ARIMA-ERNN, ERNN, and ARIMA.

Conclusion

The time series predictive models show their powerful performance in forecasting STDs incidence and can be applied by relevant authorities in the prevention and control of STDs.
Changes in leisure activities of the elderly due to the COVID-19 in Korea
Authors: Kim Eui Jae , Park Seong Man , Kang Hyun Wook
Published: August 2022

Recreational activities such as physical and social activities are key components of a healthy life for the elderly. Since the outbreak of Corona 19, leisure facilities such as indoor sports facilities, religious facilities, and cultural facilities have been closed, and group activities such as volunteer activities and clubs are also being held under control. These measures are expected to bring about many changes in the leisure activities of the elderly. In this study, an empirical analysis was made on how COVID-19 caused changes in leisure activities of the elderly using national statistical data. For the data analysis, raw data of the “2019 National Leisure Activities Survey” and “2020 National Leisure Activities Survey” conducted by the Ministry of Culture, Sports and Tourism were used, and data of a total of 5,069 elderly people were analyzed. As for the analysis method, the changes in leisure activities of the elderly before and after COVID-19 in terms of participation rate were compared and analyzed. In addition, the changes in leisure activities of the elderly in terms of the type of leisure activities were examined before and after COVID-19 as well. As a result of the analysis, the participation rate in sports activities, hobbies and entertainment activities, and leisure activities increased, while the participation rates in culture and art viewing and participation activities, sports viewing activities, tourism activities, and social activities decreased. In particular, it was found that the proportion of the elderly spending leisure time centered on active and social activities decreased, and the proportion of the elderly consuming leisure time centered on passive activities increased. As a result, it was found that the leisure activities of the elderly are changing passively due to COVID-19. Leisure support policies for active leisure activities of the elderly are likely to be necessary.
Obamacare: A bibliometric perspective
Authors: Carrasco-Aguilar Alvaro , Galán José Javier , Carrasco Ramón Alberto
Published: August 2022

Obamacare is the colloquial name given to the Affordable Care Act (ACA) signed into law by President Obama in the USA, which ultimately aims to provide universal access to health care services for US citizens. The aim of this paper is to provide an overview of the political-legal, economic, social, management (or administrative), and medical (or health) repercussions of this law, using a bibliometric methodology as a basis. In addition, the main contributors to research on ACA issues have been identified in terms of authors, organizations, journals, and countries. The downward trend in scientific production on this law has been noted, and it has been concluded that a balance has not yet been reached between the coexistence of private and public health care that guarantees broad social coverage without economic or other types of barriers. The law requires political consensus to be implemented in a definitive and global manner for the whole of the United States.
Public sentiments toward COVID-19 vaccines in South African cities: An analysis of Twitter posts
Authors: Ogbuokiri Blessing , Ahmadi Ali , Bragazzi Nicola Luigi , Movahedi Nia Zahra , Mellado Bruce , Wu Jianhong , Orbinski James , Asgary Ali , Kong Jude
Published: August 2022

Amidst the COVID-19 vaccination, Twitter is one of the most popular platforms for discussions about the COVID-19 vaccination. These types of discussions most times lead to a compromise of public confidence toward the vaccine. The text-based data generated by these discussions are used by researchers to extract topics and perform sentiment analysis at the provincial, country, or continent level without considering the local communities. The aim of this study is to use clustered geo-tagged Twitter posts to inform city-level variations in sentiments toward COVID-19 vaccine-related topics in the three largest South African cities (Cape Town, Durban, and Johannesburg). VADER, an NLP pre-trained model was used to label the Twitter posts according to their sentiments with their associated intensity scores. The outputs were validated using NB (0.68), LR (0.75), SVMs (0.70), DT (0.62), and KNN (0.56) machine learning classification algorithms. The number of new COVID-19 cases significantly positively correlated with the number of Tweets in South Africa (Corr = 0.462, P < 0.001). Out of the 10 topics identified from the tweets using the LDA model, two were about the COVID-19 vaccines: uptake and supply, respectively. The intensity of the sentiment score for the two topics was associated with the total number of vaccines administered in South Africa (P < 0.001). Discussions regarding the two topics showed higher intensity scores for the neutral sentiment class (P = 0.015) than for other sentiment classes. Additionally, the intensity of the discussions on the two topics was associated with the total number of vaccines administered, new cases, deaths, and recoveries across the three cities (P < 0.001). The sentiment score for the most discussed topic, vaccine uptake, differed across the three cities, with (P = 0.003), (P = 0.002), and (P < 0.001) for positive, negative, and neutral sentiments classes, respectively. The outcome of this research showed that clustered geo-tagged Twitter posts can be used to better analyse the dynamics in sentiments toward community–based infectious diseases-related discussions, such as COVID-19, Malaria, or Monkeypox. This can provide additional city-level information to health policy in planning and decision-making regarding vaccine hesitancy for future outbreaks.
Accurate species identification of food-contaminating beetles with quality-improved elytral images and deep learning
Authors: Bisgin Halil , Bera Tanmay , Wu Leihong , Ding Hongjian , Bisgin Neslihan , Liu Zhichao , Pava-Ripoll Monica , Barnes Amy , Campbell James F. , Vyas Himansi , Furlanello Cesare , Tong Weida , Xu Joshua
Published: August 2022

Food samples are routinely screened for food-contaminating beetles (i.e., pantry beetles) due to their adverse impact on the economy, environment, public health and safety. If found, their remains are subsequently analyzed to identify the species responsible for the contamination; each species poses different levels of risk, requiring different regulatory and management steps. At present, this identification is done through manual microscopic examination since each species of beetle has a unique pattern on its elytra (hardened forewing). Our study sought to automate the pattern recognition process through machine learning. Such automation will enable more efficient identification of pantry beetle species and could potentially be scaled up and implemented across various analysis centers in a consistent manner. In our earlier studies, we demonstrated that automated species identification of pantry beetles is feasible through elytral pattern recognition. Due to poor image quality, however, we failed to achieve prediction accuracies of more than 80%. Subsequently, we modified the traditional imaging technique, allowing us to acquire high-quality elytral images. In this study, we explored whether high-quality elytral images can truly achieve near-perfect prediction accuracies for 27 different species of pantry beetles. To test this hypothesis, we developed a convolutional neural network (CNN) model and compared performance between two different image sets for various pantry beetles. Our study indicates improved image quality indeed leads to better prediction accuracy; however, it was not the only requirement for achieving good accuracy. Also required are many high-quality images, especially for species with a high number of variations in their elytral patterns. The current study provided a direction toward achieving our ultimate goal of automated species identification through elytral pattern recognition.
Case report: Focal segmental glomerulosclerosis and nephrotic syndrome following treatment with pamidronate for calcitriol toxicity
Authors: Dawson Katherine Ann , Blong April , Walton Rebecca
Published: August 2022

Objective

This study aimed to describe a case of glomerulosclerosis resulting in nephrotic syndrome following the administration of pamidronate disodium to treat clinical calcitriol toxicity in a dog.

Case summary

A 12-week-old intact male Labrador Retriever weighing 11.8 kg presented with lethargy and vomiting for 20 h after ingesting a 100 g tube of topical antipsoriatic cream (3 mcg/g of calcitriol; Vectical Ointment™, Galderma, Lausanne, Switzerland). Severe hypercalcemia was present on the day of the presentation. Hypercalcemia treatments such as saline diuresis, furosemide (Salix®, furosemide, Merck Animal Health, Kenilworth, NJ), and dexamethasone sodium phosphate (Dexamethasone SP, Mylan, Canonsburg, PA) were initiated. The dog was also administered a single dose of pamidronate disodium (Pamidronate disodium, Mylan, Canonsburg, PA) on the day of presentation. Initially, the patient's clinical signs improved, and the hypercalcemia resolved. Exactly 130 h post-pamidronate disodium (Dexamethasone SP, Mylan, Canonsburg, PA) administration, the patient developed biochemical abnormalities and severe edema, consistent with nephrotic syndrome, and was euthanized. Necropsy results revealed evidence of focal segmental glomerulosclerosis (FSGS).

Unique information

Pamidronate disodium, commonly used for the treatment of hypercalcemia, may have resulted in glomerulosclerosis and nephrotic syndrome in a dog with calcitriol toxicity. This complication should be taken into consideration when monitoring patients treated with pamidronate disodium for hypercalcemia.
Case Report: Brentuximab Vedotin Associated Acute Pancreatitis in a Pediatric Hodgkin Lymphoma Patient: Case Report and Literature Review
Authors: Truszkowska Ewelina , Andrzejewska Marta , Szymańska Cyntia , Wziątek Agnieszka , Derwich Katarzyna
Published: August 2022

Brentuximab vedotin is a conjugate drug used mainly in Hodgkin lymphoma, systemic and primary cutaneous anaplastic large cell lymphomas, and CD30-expressing peripheral T-cell lymphoma. We report a unique case of acute pancreatitis associated with brentuximab vedotin in a 17-year-old male patient suffering from classical Hodgkin lymphoma. Diagnosed in 2020, the patient was classified to an intermediate therapeutic group and disease’s grade was IIIAE. The patient was treated with brentuximab vedotin and bendamustine in the third line. Two weeks after the drug administration, the patient developed acute epigastric pain. Laboratory and radiological findings confirmed the clinical suspicion of acute pancreatitis that was managed with opioid pain medications, meropenem, parenteral nutrition, ondansetron and omeprazole. This is the first case report of brentuximab vedotin-associated acute pancreatitis in the pediatric patient reported in the literature to the best of our knowledge.