bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring tuberculosis patient perceived quality of care in public and public–private mix settings in India: an instrument development and validation study
Authors: Periyasamy Murugesan , Thomas Beena E , Watson Basilea , Rani Sudha , A Deepalakshmi , J Vignesh Kumar , A Stephen , Jayabal Lavanya , Murugesan Jagadeesan , Ananthakrishnan Ramya , Thomas Tiju , G N Sumathi , Nagarajan Karikalan
Published: July 2022

Background

At present, there are no validated quantitative scales available to measure patient-centred quality of care in health facilities providing services for tuberculosis (TB) patients in India and low-income and middle-income countries.

Methods

Initial themes and items reflective of TB patient’s perceived quality of care were developed using qualitative interviews. Content adequacy of the items were ascertained through Content validity Index (CVI) and content validity ratio (CVR). Pilot testing of the questionnaire for assessing validity and reliability was undertaken among 714 patients with TB. Sampling adequacy and sphericity were tested by Kaiser-Meyer-Olkin and Bartlett’s test, respectively. Exploratory and confirmatory factor analysis was undertaken to test validity. Cronbach’s α and test–retest scores were used to test reliability.

Results

A 32-item tool measuring patient-perceived quality of TB distributed across five domains was developed initially based on a CVI and CVR cut-off score of 0.78 and cognitive interviews with patients with TB. Bartlett’s test results showed a strong significance f (χ2=3756 and p<0.001) and Kaiser-Meyer-Olkin was measured to be 0.698 highlighting data adequacy and correlation between the variables. Exploratory factor analysis with varimax rotation extracted 4 factors related to 14 items with Eigen values >1 which accounted for 60.9% of the total variance of items. Correlation (z-value >1.96) between items and factors was highly significant and Cronbach’s α was acceptable for the global scale (0.76) for the four factors. Intraclass correlation coefficient and the test retest scores for four factors were (<0.001) significant.

Conclusion

We validated a measurement tool for patient-perceived quality of care for TB (PPQCTB) which measured the patient’s satisfaction with healthcare provider and services. PPQCTB tool could enrich quality of care evaluation frameworks for TB health services in India.
Palliation of heart failure: value-based supportive care
Authors: Atkinson Clea , Hughes Sian , Richards Len , Sim Victor MF , Phillips Julie , John Imogen J , Yousef Zaheer
Published: July 2022

Objectives

Heart failure (HF) is a prevalent condition associated with poor quality-of-life and high symptom burden. As patients reach ceilings of survival-extending interventions, their priorities may be more readily addressed through the support of palliative care services; however, the best model of care remains unestablished.

We aimed to create and evaluate a cospeciality cross-boundary service model for patients with HF that better provides for their palliative care needs in the latter stages of life, while delivering a more cost-effective patient journey.

Methods

In 2016, the Heart Failure Supportive Care Service (HFSCS) was established to provide patient-centred holistic support to patients with advanced HF. Patient experience questionnaires were developed and distributed in mid-2018 and end-of-2020. Indexed hospital admission data (in-patient bed days pre-referral/post-referral) were used allowing statistical comparisons by paired t-tests.

Results

From 2016–2020, 236 patients were referred to the HFSCS. Overall, 75/118 questionnaires were returned. Patients felt that the HFSCS delivered compassionate care (84%) that improved symptoms and quality of life (80% and 65%). Introduction of the HFSCS resulted in a reduction in HF-related admissions: actual days 18.3 to 4 days (p<0.001), indexed days 0.05 to 0.032 days (p=0.03). Cost mapping revealed an estimated average saving of at least £10 218.36 per referral and a total estimated cost saving of approximately £2.4 million over 5 years.

Conclusion

This service demonstrates that a cospeciality cross-boundary method of care delivery successfully provides the benefits of palliative care to patients with HF in a value-based manner, while meeting the priorities of care that matter to patients most.
Reheating constraints on modified single-field natural inflation models
Authors: Zhou Hua , Yu Qing , Pan Yu , Zhou Ruiyu , Cheng Wei
Published: July 2022

In this paper, we discuss three modified single-field natural inflation models in detail, including Special generalized natural inflation model (SNI), extended natural inflation model (ENI) and natural inflation inspired model (NII). We derive the analytical expression of the tensor-to-scalar ratio r and the spectral index $$n_s$$

n
s

for those models. Then the reheating temperature $$T_{re}$$

T

re

and reheating duration $$N_{re}$$

N

re

are analytically derived. Moreover, considering the CMB constraints, the feasible space of the SNI model in $$(n_s, r)$$

(

n
s

,
r
)

plane is almost covered by that of the NII, which means the NII is more general than the SNI. In addition, there is no overlapping space between the ENI and the other two models in $$(n_s, r)$$

(

n
s

,
r
)

plane, which indicates that the ENI and the other two models exclude each other, and more accurate experiments can verify them. Furthermore, the reheating brings tighter constraints to the inflation models, but they still work for a different reheating universe. Considering the constraints of $$n_s$$

n
s

, r, $$N_k$$

N
k

and choosing $$T_{re}$$

T

re

near the electroweak energy scale, one can find that the decay constants of the three models have no overlapping area and the effective equations of state $$\omega _{re}$$

ω

re

should be within $$\frac{1}{4}\lesssim \omega _{re} \lesssim \frac{4}{5}$$

1
4

≲

ω

re

≲

4
5

for the three models.
The acoustic streaming effects of sonic black hole
Authors: Su Liang , Chen Jianwen , He Xingyun , Wang Yongqin , Liang Xiao , Chu Jiaming , Liang Haofeng , Wang Shengsheng , Nie Songhui , Liu Baixi , Wu Jiu Hui
Published: July 2022

In this paper, the acoustic streaming effects of Sonic Black Hole (SBH) are deeply studied by using the numerical and simulation method. By solving Navier–Stokes equations of compressible fluid, we analyze the flow characteristics of acoustic medium in SBH excited by sound wave, and further discuss the acoustic streaming effects and sound wave capture mechanism of SBH. The phenomenon of simultaneous reduction of medium and high-frequency sound reflection and transmission is analyzed. Under the excitation of medium- and high-frequency sound waves, the interaction between fluid medium flow and SBH structure leads to the uneven internal velocity distribution in the sound propagation direction, which can lead to the phenomenon of sound wave capture and deceleration. For low-frequency sound waves, the velocity distribution of sound medium is uniform, and there is almost no change in velocity gradient, resulting in the uniform distribution of sound pressure without sound absorption. These theoretical and numerical results are in good agreement with the experimental results in the literature, and also verify our results. Finally, by improving the structure, increasing the complexity of sound medium flow and the gradient change in the direction of sound propagation, the sound absorption and insulation ability of the SBH can be further improved. This study reveals the sound transmission mechanism of SBH, which can provide a new idea for the suppression of low-frequency sound waves in SBH.
A Self-Supervised Model Advance OCTA Image Disease Diagnosis
Authors: Li Bingbing , Ding Yiheng , Wei Ziqiang , Fu Zhijie , Sun Peng , Sun Qi , Zhang Hong , Mo Hongwei
Published: July 2022

Due to the lack of medical image datasets, transfer learning/fine-tuning is generally used to realize disease detection (mainly the ImageNet transfer model). Significant differences of dominance between natural and medical images seriously restrict the performance of the model. In this paper, a contrastive learning method (BY-OCTA) combined with patient metadata is proposed to detect the pathology in fundus OCTA images. This method uses the patient’s metadata to construct positive sample pairs. By introducing super-parameters into the loss function, we can reasonably adjust the approximate proportion of the same patient metadata sample pair, so as to produce a better representation and initialization model. This paper evaluates the performance of downstream tasks by fine-tuning the multi-layer perceptron of the model. Experiments show that the linear model pretrained by BY-OCTA is better than that pretrained by ImageNet and BYOL on multiple datasets. Furthermore, in the case of limited labeled training data, BY-OCTA provides the most significant benefit. This shows that the BY-OCTA pretraining model has better characterization extraction ability and transferability. This method allows a flexible combination of medical opinions and uses metadata to construct positive sample pairs, which can be widely used in medical image interpretation.
Reduction of Artifacts and Edge Preservation of Underwater Images Using Deep Convolution Neural Network
Authors: Somasekar M. , Murugan S. Sakthivel
Published: July 2022

Underwater exploration has been one of the areas of active research over the last few decades. Image enhancement is difficult for computer vision-based underwater research because of the degradation of the underwater environment’s images. Several types of artifact reduction approaches are already available of value averaging filters to smooth the continuity that artifact reduction approaches appear across image boundaries. While some of these approaches can somewhat reduce these unwanted artifacts’ severity, other approaches have some limitations that can cause blurring to high-contrast edges in the image. Therefore we need novel methods to overcome the theses’ drawbacks. This research work introduced a Deep Convolution Neural Network (DCNN)-based deep learning method to overcome the drawbacks of blurring to low-contrast edges in the image. The proposed system’s performance is validated through simulation, and the simulation results are obtained using Python simulation software. The obtained simulation results demonstrate the superiority of the proposed underwater image enhancement method. The number of different coefficients is compared with the results of the algorithm of the Underwater Image Colorfulness Measure (UICM), Underwater Image Sharpness Measure (UISM), Underwater Image Contrast Measure (UIconM) and Underwater Image Quality Measure (UIQM) values. After that, it was found to be an effective comparison of visualization techniques.
Industrial Control Systems Security via Runtime Enforcement
Authors: Lanotte Ruggero , Merro Massimo , Munteanu Andrei
Published: July 2022

With the advent of
Industry 4.0
, industrial facilities and critical infrastructures are transforming into an ecosystem of heterogeneous physical and cyber components, such as
programmable logic controllers
, increasingly interconnected and therefore exposed to
cyber-physical attacks
, i.e., security breaches in cyberspace that may adversely affect the physical processes underlying
industrial control systems
.

In this article, we propose a
formal approach
based on
runtime enforcement
to ensure specification compliance in networks of controllers, possibly compromised by
colluding malware
that may locally tamper with actuator commands, sensor readings, and inter-controller communications. Our approach relies on an ad-hoc sub-class of Ligatti et al.’s
edit automata
to enforce controllers represented in Hennessy and Regan’s
Timed Process Language
. We define a synthesis algorithm that, given an alphabet 𝒫 of observable actions and a timed correctness property
e
, returns a monitor that enforces the property
e
during the execution of any (potentially corrupted) controller with alphabet 𝒫, and complying with the property
e
. Our monitors do
mitigation
by correcting and suppressing incorrect actions of corrupted controllers and by generating actions in full autonomy when the controller under scrutiny is not able to do so in a correct manner. Besides classical requirements, such as
transparency
and
soundness
, the proposed enforcement enjoys
deadlock- and diverge-freedom
of monitored controllers, together with
scalability
when dealing with networks of controllers. Finally, we test the proposed enforcement mechanism on a non-trivial case study, taken from the context of industrial water treatment systems, in which the controllers are injected with different malware with different malicious goals.
The Application of Nanoparticle Ceramic Materials in the Design of Modern Handicrafts
Authors: Gao Zhimin , Lee Seungjin , Huang Jiaxi
Published: July 2022

With the development of society, people’s purchasing power is gradually increasing, and more and more people choose to buy handicrafts. The popularity of handicrafts has also promoted the development of production technology and production materials, and high‐quality handicrafts are most favored by consumers. As an enduring material, ceramics are also under continuous development. This article is aimed at studying nanoceramic materials and gaining a detailed understanding of the classification, structure, and manufacturing process of nanoceramic materials. In the experimental stage of this article, through the analysis of whether nanoceramic materials and technology are used in modern crafts, it is verified whether nanoceramic materials contribute to the advancement of modern craft design and the growth of product sales. This article shows through experimental research that the application of nanoceramic materials to handicrafts can not only increase its sales by more than 30% but also increase its sales unit price by 36%.
Research on the Extraction Technology of Gas-Integrated Working-Face in Close Coal Seam Mining in Permafrost Area
Authors: Wu Chao , Deng Rongbin
Published: July 2022

In order to understand the mechanical deformation characteristics of the permafrost layer and the stress-fracture-gas seepage law of the superimposed mining of the proximity coal seam group, a coupled gas-solid model of the proximity coal seam in the permafrost area was constructed based on the theoretical model of small deflection of thin plate and the deformation control equation, gas transport equation, porosity evolution equation and permeability evolution equation of the coal rock body, and the analysis of the dependent project. The analysis was carried out at the NMT coal mine. The results show that the multiyear permafrost seam in the NMT coal mine has a tendency to move to the left and will produce extensive pull damage near the right end. The initial and periodic collapse steps are 192.87 m and 43.24 m, respectively; the pore and fissure structural characteristics of the NMT coal seam are not conducive to gas transport, and the stress and fissure fields have a nonlinear increasing effect. The study also proposed the “protected seam mining and bottom extraction lane directional drilling group comining technology” to increase the daily production of working face by 25.8%. The results of the study can be used as a reference for similar projects.
Analysis of Competitiveness and Complementarity of Chinese Fruits and Vegetables in Pakistani Market in the Context of Industrial Internet of Things
Authors: Wang Bin , Zhang Ya-ting , Wang Ting , Li Hong , Zhou Chang-ming , Wu Ting
Published: July 2022

The digital revolution changes the perception of the economy and business. The emergence of the industrial internet of things (IIoT) poses a large impact on established business models of manufacturing companies. As an important economic partner of China in South Asia, Pakistan plays an important role in the Belt and Road Initiative. This paper based on the three models: trade specialization coefficient (TSC) index, revealed comparative advantage (RCA) index, and trade complementarity (TC) index, analyzes the competitiveness and complementarity of Chinese Fruit and Vegetable (F&V) trade between China and Pakistan. The results showed that China-Pakistan had their own comparative advantages in F&V export, and there was a big difference in the types of F&V, and the competitiveness of F&V export between them was weak. The import and export structure of F&V between China and Pakistan is consistent, and there is strong trade complementarity. Therefore, it is suggested that China-Xinjiang and Pakistan should establish an import and export cooperation mechanism for F&V and export F&V with strong complementarity to each other. We should build a well-connected logistics network, which relies on the geographical advantages of Xinjiang, and comprehensively upgrade the level and quality of agricultural cooperation with Pakistan to enhance the agricultural cooperation between China and Pakistan. At the same time, China-Pakistan should strengthen cooperation in agricultural technology, trade, and equipment so as to achieve win-win results.
Waveform Reconstruction of DSSS Signal Based on VAE-GAN
Authors: Feng Qi , Zhang Junyi , Chen Li , Liu Fang
Published: July 2022

The complex electromagnetic environment will limit the efficacy of communication equipment. It is critical to construct a complex electromagnetic environment to test communication equipment in order to maximize its capability. One of the most important methods for constructing a complex electromagnetic environment is signal reconstruction. This paper proposes a VAE-GAN-based method for reconstructing direct sequence spread spectrum (DSSS) signals. In this method, the deep residual shrinkage network (DRSN) and self-attention mechanism are added to the encoder and discriminator of VAE-GAN. In feature learning, the DRSNs can reduce the redundant information caused by noise in the collected signal. The self-attention mechanism can establish the long-distance dependence between the input sequences, making it easier for the network to learn the samples’ pseudonoise (PN) sequence features. In addition, feature loss is applied to the encoder and generator to improve network stability during training. The results of the experiments indicate that this method can reconstruct DSSS signals with the characteristics of the target signal.
Research on Data Fusion Method Based on Multisource Data Awareness of Internet of Things
Authors: Sun Fanglei , Diao Zhifeng
Published: July 2022

The diversity of big data in Internet of Things is one of the important characteristics that distinguish it from traditional big data. Big data of Internet of Things is often composed of a variety of data with different structural forms. The description of the same thing by these different modal data has certain independence and strong relevance. Accurately and efficiently extracting and processing the hidden fusion information in the big data of the Internet of Things is helpful to solve various multimodal data analysis tasks at present. In this paper, a multimodal interactive function fusion model based on attention mechanism is proposed, which provides more efficient and accurate information for emotion classification tasks. Firstly, a sparse noise reduction self-encoder is used to extract text features, Secondly, features are extracted by encoder. Finally, an interactive fusion module is constructed, which makes text features and image features learn their internal information then the combination function is applied to the emotion classification task.
PKCι Is a Promising Prognosis Biomarker and Therapeutic Target for Pancreatic Cancer
Authors: Abdelatty Alaa , Fang Dan , Wei Guanqun , Wu Fubing , Zhang Chengfei , Xu Haojun , Yao Chengyun , Wang Yundong , Xia Hongping
Published: July 2022

Background: As the highest prevalent pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) ranks the 7th lethal malignancy worldwide. The late diagnosis, chemotherapeutic resistance, and high associated mortality make PDAC a dilemma facing the oncologists. Protein kinase C (PKC) enzymes have been shown to be important in different cancer progression. Methods: To understand the pattern of PKC enzymes in PDAC, we examined all PKC family member genes expression in PDAC and matched normal tissues. The critical role of PKCι was further investigated in different PDAC cells using cellular and molecular technology. Results: We found that PRKCI (PKCι) was the most significantly overexpressed PKCs in pancreatic cancer. However, little is known about its role and regulation of oncogenic signaling pathways in pancreatic cancer. In this study, we confirmed the overexpression of PKCι in PDAC, and this high expression was associated with poor prognosis of patients. We proved that knockdown of PKCι by small interfering RNA or shRNA significantly inhibited pancreatic cancer cell growth and migration or invasion. Conversely, PKCι overexpression promoted pancreatic cancer cell growth and migration. Moreover, bioinformatical and technical studies informed the participation of PKCι in regression of apoptosis in PDAC cells, which may be related to the regulation of both PI3K/AKT and Wnt/β-catenin pathways. Conclusions: Therefore, our results are adding more insight into the importance of PKCι in pancreatic cancer. PKCι induces pancreatic cancer progression through activation of PI3K/AKT and Wnt/β-catenin signaling pathways, which may provide a promising therapeutic target for pancreatic cancer.
A Real-World Study in Patients with Type 2 Diabetes Treated with Gliclazide Modified Release during Fasting in Gulf Cooperation Council Countries: An Analysis from the International DIA-RAMADAN Study
Authors: Hassanein Mohamed , Al Sifri Saud , Al Awadi Fatheya , Alessa Thamer , Shaaban Ashraf
Published: July 2022

Introduction: The safety and effectiveness of gliclazide modified release (MR) in patients with type 2 diabetes mellitus (T2DM) who fasted during Ramadan were previously published. Here, we carried out a regional analysis among patients living in Gulf Cooperation Council (GCC) countries. Patients and Methods: DIA-RAMADAN was a real-world, observational, international, noncomparative study conducted in nine countries that included >1200 T2DM adults receiving gliclazide MR for at least 90 days before inclusion. The study comprised 2 visits: at inclusion, 6–8 weeks before the start of Ramadan (V0) and 4–6 weeks after the end of Ramadan (V1). The primary endpoint was the proportion of patients reporting ≥1 symptomatic hypoglycemic event as collected using a patient diary. Changes in HbA1c, fasting plasma glucose (FPG), and weight were also analyzed. This manuscript represents data collected in GCC countries (Kuwait, Saudi Arabia, and United Arab Emirates). Results: Data from 161 patients were analyzed: mean (SD) age 56.8 (10.6) years, 30.4% women, body mass index 29.1 (3.7) kg/m2, T2DM disease duration 6.7 (3.3) years, baseline HbA1c 7.9% (0.8). The proportions of patients reporting ≥1 symptomatic hypoglycemic event or confirmed hypoglycemia during Ramadan were 4.3% and 0.6%, respectively. No cases of severe hypoglycemia were reported. Significant reductions in main variables were observed before the start of Ramadan (V0) and 4–6 weeks after the end of Ramadan (V1): HbA1c (from 7.9 [0.8] to 7.6 [0.7]%; p value <0.001), FPG (from 143.5 [24.3] to 137.9 [25.2] mg/dL; p value = 0.031), and weight (from 79.0 [73.0–86.0] to 78.0 [72.0–85.0] kg; p value = 0.018). Conclusions: These real-world data indicate that patients with T2DM treated with gliclazide MR during Ramadan in the selected GCC countries have a low risk of hypoglycemia and maintain glycemic control and weight while fasting.
NETwork Meta-analysis Of Trials of Initial Oxygen in preterm Newborns (NETMOTION): A Protocol for Systematic Review and Individual Participant Data Network Meta-Analysis of Preterm Infants <32 Weeks’ Gestation Randomized to Initial Oxygen Concentration for Resuscitation
Authors: Sotiropoulos James X. , Oei Ju Lee , Schmölzer Georg M. , Hunter Kylie E. , Williams Jonathan G. , Webster Angela C. , Vento Maximo , Kapadia Vishal , Rabi Yacov , Dekker Janneke , Vermeulen Marijn J. , Sundaram Venkataseshan , Kumar Praveen , Saugstad Ola D. , Seidler Anna Lene
Published: July 2022

Background: Internationally recognized guidelines recommend the judicious use of low oxygen (21–30%), titrated to peripheral oxygen saturation targets, for the initiation of resuscitation of very and extremely preterm infants (<32 weeks’ gestation). However, despite more than 10 randomized controlled trials on this question, the ideal initial oxygen concentration for this group of vulnerable infants remains uncertain. Aims: This study aims to assess the effect of various initial oxygen concentrations on (1) all-cause mortality, chronic lung disease, intraventricular hemorrhage, and retinopathy of prematurity; and (2) reaching the prescribed oxygen saturation targets by 5 min after birth, in preterm infants requiring resuscitation. Methods: We will conduct a systematic review and network meta-analysis using individual participant data. Studies of preterm infants <32 weeks’ gestation, randomized to initial oxygen concentration, will be included. We will systematically search medical databases and trial registries for eligible studies (published or unpublished). Records will be screened by two independent reviewers, with conflicts resolved by the inclusion of a third reviewer. Identified initial oxygen concentrations will be grouped into the following nodes: low (≤30%), intermediate (60%), and high (≥90%) oxygen. A two-step random-effects contrast-based network meta-regression will be calculated to compare and rank different oxygen concentrations. Analyses will be intention-to-treat, with the primary outcome of all-cause mortality. Discussion: This is the first individual participant data network meta-analysis of initial oxygen concentrations for the resuscitation of preterm infants. This novel approach may address long-standing uncertainty regarding optimal oxygen supplementation practice for the resuscitation of preterm infants <32 weeks’ gestation.
Circumscribed Morphea of the Scalp: An Entity to Be Considered in the Differential Diagnosis of Cicatricial Alopecia
Authors: Romagnuolo Maurizio , Moltrasio Chiara , Barbareschi Mauro , Barberi Francesco , Riva Davide , Di Benedetto Alessandra , Boggio Francesca
Published: July 2022

Introduction: Morphea, also known as localized scleroderma, could affect the head and neck region, mainly manifesting in a linear pattern. Localized scleroderma of the scalp presenting as a circumscribed alopecic patch has been described as an unusual clinical entity. We present a new case of circumscribed morphea of the scalp. Case Report: We present the case of a 33-year-old man with a single cicatricial alopecic patch of the scalp. The main clinical, trichoscopic, and histopathological findings are described. Conclusion: We suggest considering scalp morphea in the differential diagnosis of mono-lesional cicatricial alopecia involving the scalp.
Uveamelanom: Neue Therapieoption zugelassen
Authors: Klespe Kai-Christian
Published: July 2022

In der IMCgp100–202 Studie wurden zuvor unbehandelte HLA-A*02:01-positive Patienten mit metastasiertem Aderhautmelanom im Verhältnis 2:1 nach dem Zufallsprinzip entweder mit Tebentafusp (Tebentafusp-Gruppe) oder einer Therapie nach Wahl des Prüfarztes mit Pembrolizumab, Ipilimumab oder Dacarbazin (Kontrollgruppe) behandelt, stratifiziert nach dem Laktatdehydrogenase-Spiegel. Der primäre Endpunkt war das Gesamtüberleben. Die Gesamtüberlebensrate nach einem Jahr betrug 73% in der Tebentafusp-Gruppe und 59 % in der Kontrollgruppe (Hazard Ratio für Tod 0,51; 95% Konfidenzintervall [CI] 0,37 bis 0,71; P<0,001) in der Intention-to-Treat-Population. Das progressionsfreie Überleben war in der Tebentafusp-Gruppe ebenfalls signifikant höher als in der Kontrollgruppe (31% gegenüber 19% nach 6 Monaten; Hazard Ratio für Krankheitsprogression oder Tod, 0,73; 95% CI, 0,58 bis 0,94; P = 0,01). Die häufigsten behandlungsbedingten unerwünschten Ereignisse in der Tebentafusp-Gruppe waren zytokinvermittelte Ereignisse (aufgrund von T-Zell-Aktivierung) und hautbezogene Ereignisse (aufgrund von Glykoprotein-100-positiven Melanozyten), einschließlich Hautausschlag (83%), Pyrexie (76%) und Pruritus (69%). Die Häufigkeit und der Schweregrad dieser unerwünschten Ereignisse nahmen nach den ersten 3 oder 4 Dosen ab und führten nur in seltenen Fällen zum Abbruch der Studienbehandlung (2%). Es wurden keine behandlungsbedingten Todesfälle gemeldet.
Evaluating HEmopatch® in Reducing Seroma-Related Complications following Axillary Lymph Node DIssection: A Pilot Study (HEIDI)
Authors: Spiekerman van Weezelenburg Merel A. , de Rooij Lisa , Aldenhoven Loeki , Broos Pieter P.H.L. , van Kuijk Sander M.J. , van Haaren Elisabeth R.M. , Janssen Alfred , Vissers Yvonne L.J. , Beets Geerard L. , van Bastelaar James
Published: July 2022

Purpose: Axillary lymph node dissection (ALND) is performed to treat locoregional metastatic disease in breast cancer and melanoma patients. However, it is notorious for its complications, most commonly seroma formation and its sequelae. Ample research has been done to evaluate seroma formation after ALND; these results, however, have not been conclusive. Hence, this pilot study aimed to evaluate a readily available haemostatic patch, Hemopatch®, to assess its effect on seroma formation following ALND. Methods: In this pilot study, a prospective cohort of 20 patients receiving Hemopatch® following ALND was compared to a retrospective cohort of patients who underwent ALND between 2014 and 2019. The primary outcome measure was the number of patients developing clinically significant seroma (CSS) after ALND. Additionally, the number of wound complications, subsequent interventions, additional outpatient clinic visits, and drain output was assessed. Differences between groups were deemed clinically relevant if the proportions differed >50% between groups. Results: In total, 20 prospective and 42 retrospective patients were included. In the Hemopatch® group, 30% of the patients developed CSS, compared to 43% in the control group. Three patients in both groups developed a surgical site infection . Thirty-five percent of patients in the Hemopatch® group required additional unscheduled visits versus 62% of patients in the control group. Conclusion: The application of Hemopatch® after ALND did not lead to a clinically relevant reduction of CSS and wound complications. However, fewer Hemopatch® patients required additional outpatient clinic visits. Due to the limited amount of participants, the true value of Hemopatch® in ALND remains unclear.
Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat
Authors: Suzuki Jiro , Nagase Masashi , Sato Naoko , Takahashi Yukari , Okamoto Aikou , Kato Fusao
Published: July 2022

Introduction: Despite its recent reputation as prosocial neurohormone, the most important physiological role of oxytocin (OT) is stimulating uterine contractions. Though it is well known that plasma OT concentrations change drastically during delivery, it remains unexplored whether and how OT receptors in the maternal brain are activated. We examined whether the responses of cells in the central amygdala (CeA), an OT receptor-rich limbic site involved in pain and fear memory regulation, to exogenously applied OT analogue, Thr-Gly-OT (TGOT), vary depending on delivery. Methods: Intracellular Ca2+ dynamics of the CeA cells were visualized in brain slices from female rats at virgin (VG), during pregnancy term (PT) days 16–21, within 24 h after delivery (G0), and within 1–3 days after delivery (G3). The Ca2+ responses to 1 µM TGOT, 20 mM KCl (high K), and 300 µM ADP were compared. Results: We found that fraction of cells responding to TGOT, high K, and ADP differed significantly between the four delivery-associated terms. In particular, the fraction of cells responding to TGOT (TGOT responders) significantly increased from VG and PT at G0 and G3. Furthermore, the significant positive correlation between TGOT and high K response in TGOT and high K responders was reduced at G0, while that between TGOT and ADP responses in TGOT and ADP responders was increased at G0. Conclusion: These results indicate that the responses of CeA cells to an OT receptor agonist markedly change around delivery, which might play a role in controlling the labor-related pain and post-delivery emotional complications.
Molecular survey of Leishmania spp. in skin samples of capybaras (Hydrochoerus hydrochaeris) from different areas of Brazil
Authors: Pereira Agnes Antônia Sampaio , Benatti Hector Ribeiro , Mori Carina Carvalho , Estevam Letícia Gracielle Tôrres de Miranda , Gontijo Célia Maria Ferreira , Luz Hermes Ribeiro , Labruna Marcelo Bahia , Paz Gustavo Fontes
Published: July 2022

Leishmaniases comprise a spectrum of diseases caused by protozoan parasites of the genus Leishmania, with some species of rodents being incriminated as reservoirs. The capybara is the largest extant rodent species in the world and is widely distributed in South America. The occurrence of infection by Leishmania spp. was investigated in capybaras captured in Brazil during 2015–2019 from established populations in five highly anthropic areas of the state of São Paulo and two natural areas of the states of Mato Grosso and Mato Grosso do Sul. A total of 186 individuals were captured and subjected to abdominal skin biopsy. All skin samples were Leishmania kDNA-negative, suggesting that capybaras have no role in the transmission cycles of Leishmania species in the studied areas despite the well-known role of other rodents in the life cycle of Leishmania spp.
ÜLKEMİZDE GERÇEKLEŞTİRİLEN ETİK KOD ÇALIŞMALARININ NİTEL ANALİZİ: ULAKBİM VERİ TABANI ÖRNEĞİ
Authors: KILINÇ Erman
Published: July 2022

Bu çalışmanın amacı, ULAKBİM veri tabanında yer alan “etik kod” ile ilgili Türkçe makalelerin nitel açıdan analiz edilmesidir. Çalışmada, ULAKBİM veri tabanında yer alan tüm disiplinlere ait makaleler “etik kod” ve “etik kodlar” kelimeleriyle filtrelenmiştir. Filtreleme işlemi makale başlıkları ve anahtar kelimelere uygulanmıştır. Filtreleme sonucunda analize uygun on iki makaleye NVivo 12 programıyla nitel analiz teknikleri uygulanmıştır. Araştırma sonucunda, etik kodlarla ilgili en yüksek frekanslı kelimelerin “etik, sosyal, bilimsel, psikolojik ve yönetime” olduğu görülmüştür. Analize kelime bulutu ve kavram haritası oluşturularak devam edilmiştir. Daha sonra, “etik” kodlarla ilgili ağaç haritası oluşturulmuştur. Son olarak, veri havuzunda yer alan kelimeler birbirleriyle ilişkilendirilerek kümeleme analizi yapılmıştır. Çalışma sürecinde, ülkemizde yazılan etik kod ile ilgili makale sayısının yeterli olmadığı ve mevcut makalelerden bazılarının farklı kavramlarla ifade edilerek etik kod konusunda kavram karmaşasının olduğu görülmüştür.
ÜCRETLİ EV İŞLERİNDE ÇALIŞAN KADINLARIN GÜNDELİK YAŞAMI VE TÜKETİM ALIŞKANLIKLARI ÜZERİNE BİR İNCELEME
Authors: SARI Gülşah , YILMAZ BİLECEN Meltem
Published: July 2022

Bu çalışma evlere temizliğe giderek ücretli emek sürecine eklemlenen kadınların gündelik hayatlarını, kazandıkları para üzerindeki tasarruflarını, tüketim alışkanlıklarını ve çalışıyor olmanın onların hayatlarında yaptığı değişiklikleri ortaya koymak amacıyla hazırlanmıştır.

Çalışmada İstanbul Ataşehir’de evlere temizliğe giden on kadınla yüz yüze derinlemesine mülakat tekniğiyle görüşmeler gerçekleştirilmiş olup görüşmeler esnasında temelde kırk altı sorunun yer aldığı soru formundan hareket edilmiştir. Beş temel kategori altında değerlendirilen görüşmelerde kadınlara ilişkin demografik verilere, aile yaşantılarına, kazançları ve tüketme alışkanlıklarına, sosyal medya kullanımı biçimlerine, çalışmanın onların hayatlarında yarattığı değişikliklere odaklanılmıştır. Çalışmada ücretli ev işlerinde çalışan kadınların kent hayatına uyum süreci ve tüketim alışkanlıklarında çalıştıkları evlerdeki orta ve üst sınıf ailelerinin katkısının olduğu sonucuna varılmıştır.
GİRİŞİMCİLİĞE ODAKLANAN BİR ÖĞRENEN ŞEHİR
Authors: KORKMAZ H. Ufuk
Published: July 2022

Girişimcilik her yaştan ve her alandan paydaşlarla birlikte yürütüldüğünde şehrin gelişimine ve kalkınmasının sürdürülebilirliğine katkı sağlamaktadır. Öğrenen şehirler ise hem bireysel gelişime hem de kültürel çeşitliliğe etki etmektedir. Çalışmada UNESCO Öğrenen Şehirler Küresel Ağı’na göre girişimciliğe odaklanan bir öğrenen şehrin katkısı önerilerle açıklanmaktadır. Öğrenen Şehirlerin temel yapı taşlarından biri “Hayat boyu öğrenme kültürünün teşvik edilmesi” dir. UNESCO Öğrenen Şehirler Küresel Ağı’nda yer alan ve girişimciliğe odaklanan bir öğrenen şehir olarak başarılı uygulamaları hayata geçirmiş Swansea şehri; “Girişimciliğe odaklanan bir öğrenen şehir” olarak kendini tanımlamaktadır Türkiye’den kabul edilen ilk iki şehir Eskişehir ve Konya’dır. Türkiye’deki şehirlerin, UNESCO Öğrenen Şehirler Küresel Ağı’na katılımının teşvik edilmesi amacıyla gerçek deneyimleri içeren bir çalışmadır. Bu ağa katılmak isteyen ve girişimciliğe odaklanan öğrenen şehir olma yolunda adım atmak isteyen şehirlerde yapılabilecek uygulamalara ilişkin öneriler oluşturularak sunulmuştur.
KAMUYU BİLGİLENDİRME MODELİ BAĞLAMINDA COVİD-19 PANDEMİSİNE İLİŞKİN YAPILAN BİLGİLENDİRMELERİN ALGILANMASI: BOLU İLİ ÖRNEĞİ
Authors: AKAR Fatma
Published: July 2022

Bu çalışmanın amacı iki yıldan fazla bir zamandır tüm Dünya’yı ekonomik, psikolojik ve sosyolojik açıdan olumsuz etkileyen Covid-19 pandemisi sürecinde Türkiye Cumhuriyeti Sağlık Bakanlığı tarafından pandemi ile ilgili çeşitli araç ve ortamlarda gerçekleştirilen bilgilendirme faaliyetlerinin toplum tarafından nasıl algılandığını ölçmektir. Çalışmanın evrenini Bolu’da ikamet eden 15 yaş üstü bireyler ve örneklemini ise bu kişiler arasından rastgele seçilen 355 kişi oluşturmaktadır. Çalışmada elde edilen veriler nicel araştırma yöntemlerinden biri olan anket tekniği ile toplanmıştır. Anket çalışması pandemi şartlarından dolayı Google Anket uygulaması ile çevrimiçi olarak gerçekleştirilmiştir. Çalışmada sonucunda elde edilen verilere bakıldığında katılımcıların %76,1 gibi yüksek bir oranının aşı olduğu, cinsiyet açısından kadınların, yaş olarak 41-60 yaş aralığındaki bireylerin ve aşı olmayanlardan ziyade aşı olanların Sağlık Bakanlığı tarafından Covid-19 pandemisi ile ilgili yapılan bilgilendirme çalışmalarına daha fazla önem verdikleri, ayrıca aşı olanların ve üniversite mezunlarının Covid-19 virüsü ile ilgili daha fazla kaygı ve endişe duydukları tespit edilmiştir.
AKILLI ŞEHİRLERDE VERİ YÖNETİMİ YAKLAŞIMLARI
Authors: TAMER Halil Yasin
Published: July 2022

Bu çalışmada, ilk olarak T.C. Çevre, Şehircilik ve İklim Değişikliği Bakanlığı’nın hazırladığı “2020-2023 Ulusal Akıllı Şehir Stratejileri ve Eylem Planı” belgesinin içerik analizi yöntemiyle incelenmesi sonucunda veri yönetimi konusunun eksikliği tespit edilmiş ve bundan hareketle ‘kentsel veriler nasıl yönetilebilir’ sorusuna kamu yönetimi bağlamında yanıt aranmıştır. Amaç, kamu yönetimi literatüründe ve bahsi geçen belgede veri yönetimine dönük eksiklikleri ortaya koymak ve buna uygun çözüm önerileri getirmektir. Bu amaçla, akıllı şehir, veri, veri yönetimi kavramlarına ilişkin literatür taranmıştır. Kavramsal çerçeve belirlendikten sonra, akıllı şehir tasarımını belirleyecek belgeler ve akıllı şehirlerde veri yönetimine dönük çalışmalar içerik analiziyle incelenmiştir. Bu incelemeyle, literatürün temel eksikliğinin, sosyo-teknik incelemelerin göz ardı edilmesi ve veri yönetimi yaklaşımlarının kamu yönetimi perspektifinden değerlendirilmemesi olduğu anlaşılmıştır. Bu bulgular ışığında, akıllı şehir tasarım, strateji ve politikalarına veri yönetimi bağlamında çözüm önerileri getirilmiştir.
KADINLARIN MUTLULUĞUNUN YORDAYICILARI OLARAK ÖZ-ŞEFKAT VE OLUMLU ÇOCUKLUK YAŞANTILARI
Authors: TUNCA Aslı
Published: July 2022

Araştırmanın temel amacı, kadınların öz-şefkat düzeylerinin ve olumlu çocukluk yaşantılarını algılayışlarının mutluluklarını yordama gücünü belirlemektir. Araştırma, ilişkisel araştırma modelinde nicel bir çalışmadır. Araştırmaya yaşları 18-64 arasında değişen 449 kadın katılmıştır. Bulgulara göre; kadınların mutluluğu yaşanılan yer ve çalışma durumuna göre anlamlı farklılık göstermezken, ebeveyn olan kadınların mutluluk düzeyleri daha yüksek bulunmuştur. Öz-şefkat ve olumlu çocukluk yaşantılarının kadınların mutluluğunun pozitif yönde önemli bir yordayıcısı olduğu saptanmıştır. Kadınların toplumsal cinsiyet rolleri sebebiyle olumsuz durumları deneyimleme olasılıkları göz önünde bulundurulduğunda öz-şefkat ve olumlu çocukluk yaşantılarını geliştirmeye yönelik müdahalelerin bu çalışma ile önemi anlaşılmıştır. Ruh sağlığı uzmanları, kadınlara öz-şefkati geliştirici ve olumlu çocukluk yaşantılarını arttırıcı psiko-eğitimler ve terapi yaklaşımları sunabilirler.
Covid 19 Pandemisinin Yerel Ekonomik Etkileri: Isparta İli Dış Ticareti Üzerine Bir İnceleme
Authors: ÖZMEN Fatma
Published: July 2022

Dünya genelinde bir salgına yol açan Covid - 19 virüsü, 2020 mart ayında Pandemi olarak ilan edildiği günden bu yana hayatın her alanını geri döndürülemez bir şekilde etkilemiş bulunmaktadır. Yarattığı tahribatlar göz önüne alındığında ülkelerin pandemi gibi durumlara karşı hazırlıksız olduğu ortaya çıkmıştır. Bu çalışmada, öncelikle pandeminin ortaya çıkış süreci ve ekonomiye olan etkileri ele alınmış ve ilgili literatür taranmıştır. Salgınının küresel, ulusal ve yerel boyuttaki ekonomik etkilerine ilişkin değerlendirme yapılmaya çalışılmıştır. Sonrasında da salgının yerel düzeyde Isparta ili ekonomisi üzerine etkisi üzerinde durulmuştur. Yerel düzeydeki pandemi etkilerini Isparta ili özelinde uluslararası ticaret işlemleri yönünden incelenmeye çalışılmıştır. Bu bağlamda değişimi ortaya koyabilmek için yayınlanmış raporlar ve istatistiki veriler incelenerek pandemi öncesi ve sonrası durum hakkında bir karşılaştırma yapılmaya çalışılmıştır.
Türkiye'de Kadına Yönelik Dilsel Şiddet
Authors: USTA Çiğdem
Published: July 2022

Şiddet, maddi ve(ya) manevi kuvvet vasıtasıyla bireyin kişisel sınırlarının ve haklarının ihlalidir. Şiddetin fiziksel, cinsel, ekonomik, dilsel olmak üzere pek çok çeşidi vardır. Fiziksel şiddet görünürlüğü nedeniyle üzerinde en çok durulan ve bilinen şiddet türüdür. En az fiziksel şiddet kadar insan ruhuna zarar veren dilsel şiddet ise muhtemelen en sık uygulanan şiddet şeklidir. Çoğunlukla “küfür” olarak algılanan bu ihlal, gerçekte hakaret, tehdit, alay, iftira, kıyaslama, lakap takma, sözlerini çarpıtma vb. pek çok farklı görünüme sahiptir. Çalışmada Türkiye’de kadına yönelik dilsel şiddet üzerinde durulacak, bu konuda genel bir çerçeve çizilmeye çalışılacaktır.
SOSYAL MEDYA GÖRÜNÜRLÜĞÜ İLE MARKA GÜCÜ VE DEĞERİ ARASINDAKİ İLİŞKİSİNİN İNCELENMESİ: GLOBAL MARKALAR ÜZERİNE AMPRİK BİR İNCELEME
Authors: TOPUZ Yusuf Volkan
Published: July 2022

Bu çalışmanın amacı markaların sosyal medya görünürlükleri ile marka gücü ve marka değeri arasındaki ilişkiyi incelemektedir. Bu kapsamda, markaların sosyal medya performansını belirlemek amacıyla BrandWatch tarafından hesaplanan; Sosyal Görünürlük, Web Görünürlüğü ve Arama Görünürlüğü endeksleri bağımsız değişken olarak ele alınmıştır. Çalışmanın bağımlı değişkenleri ise BrandFinance tarafından hesaplanan Marka Gücü Endeksi (BSI) ve Marka Değeri’dir. 148 Global marka verisinin dahil edildiği çalışmada değişkenler arasındaki ilişki yol analizi ile test edilmiştir. Analizler sonucunda, sosyal medya görünürlüğünün markanın gücünü ve marka değerini istatistiksel olarak anlamlı şekilde pozitif yönlü olarak etkilediği görülmüştür.
ANTEP FISTIĞI VE TÜREVLERİNİN GAZİANTEP YEREL GASTRONOMİK KİMLİĞİNDEKİ YERİ
Authors: BAYCAR Abdullah
Published: July 2022

Dünyanın önemli Antep fıstığı yetiştiricilerinden birisi Türkiye’dir. Fıstığın; Gaziantep yerel gastronomik kimliğindeki pozisyonundan dolayı ülke sınırları içerisinde ilin ismiyle anılan ender ürünlerdendir. Tarihi, ekonomideki yeri ve diğer sosyal yapılarla bütünleşmesi Antep fıstığının lokal gastronomideki konumunu taklit edilemeyecek bir seviyeye ulaştırmıştır. Bu çalışmadaki amaç, yöresel ürünler içerisinde yer alan Antep fıstığı ve türevlerinin yerel gastronomik kimlik gelişim aşamalarındaki yerlerini açığa çıkarmaktır. Araştırma verileri; saha ziyaretleri, ziyaret esnasındaki görüşmeler, medya analizleri, birincil ve ikincil kaynak taramalarıyla elde edilmiştir. Antep fıstığının lokal gastronomik kimlikte yer alan; çerezlik fıstık, fıstıklı baklava, fıstıklı kadayıf, fıstıklı katmer, Antep fıstık şekeri, Antep fıstık ezmesi, Antep fıstıklı cezerye, Gaziantep Fıstık Müzesi, fıstık heykelleri, gastronomi kursları ve Uluslararası Antepfıstığı Kültür ve Sanat Festivali gibi birçok öğesi mevcuttur. Çalışma sonucunda Antep fıstığına ait her unsurun yerel gastronomik kimlikteki yeri saptanmıştır.
COVID-19 Pandemisinin Seramik Sanayiine Etkileri
Authors: OBUT BİLİM Zehra , AVCI Sedat
Published: July 2022

COVID-19 pandemisi tüm dünyaya yayılarak, başta sağlık ve ekonomi olmak üzere birçok sektörü olumsuz etkilemiştir. 21. yüzyılda meydana gelen bu pandemi diğer salgınlardan farklı olarak daha geniş coğrafi bölgelere yayılmıştır. Ekonomik faaliyetlerin küreselleşmesi, ticari ilişkilerin de salgından etkilenmesi bütün dünya ülkeleri için geçerlidir. Çalışmanın amacı; COVID-19 pandemisinin ekonomik etkilerinin dünyada ve Türkiye’de seramik sanayii açısından değerlendirilmesidir. İstatistiki verilerden; Trade Map; GTİP 69- 6907-6910 kodlu ihracat-ithalat verileri değişimlerinden hareketle seramik sanayiinde pandeminin etkileri ortaya konulmuştur. Seramik sanayiinde birçok ülkenin üretim, ihracat ve ithalat faaliyetlerinin olumsuz etkilendiği gözlemlenmişken Türkiye’nin pandemide seramik sanayii ihracatını arttırdığı ortaya çıkmıştır.
HEİDEGGER’İN DASEİN İÇİN İNŞA ETTİĞİ-MESKENDE/N GÖRÜLEN-TOPLUMSAL TEZAHÜRLER
Authors: ERTÜRK Mustafa
Published: July 2022

Yirminci yüzyılın önemli düşünürlerinden Heidegger’in varlığa ilişkin ontolojik soruşturmasının düşünce dünyasında önemli etkileri olmuştur. Bu çalışmada birbiri üzerine katlanan ve Heidegger’in düşüncesinde bütünlüklü bir yapı görünümü sunan iki düzlem aynı anda kat edilmektedir. Bunlardan birincisi, Heidegger’in temel sorunsalı Dasein’ın görünümlerinin, mekân, yer, yakınlık ve uzaklık gibi mekansal kavramsallaştırmalar dolayımında toplumsal imkanının soruşturulması; ikinci düzlem ise Dasein’ın toplumsal görünümlerinin ‘mesken’ ve ‘inşa’ kavramları bağlamında tekrar çerçevelenmesidir. Bu tartışma aynı zamanda Heidegger'in düşüncesindeki felsefe (ontik/ontolojik varlık, metafizik, Dasein) ile sosyoloji (toplum, bir arada var olma, toplumsal) arasındaki etkileşimin olasılığını mekân, yer, mesken ve bina gibi mimarlık disiplinin kavramları dolayımıyla ortaya koymaktadır. Sonuçta, Heidegger’in Dasein için inşa ettiği meskenin toplumsal yönüne dikkate değer bir teklif sunduğu görülmektedir; bu, her şeyden önce “-ile birlikte” varlığın, insan topluluğunun dünya ile yeni bir ilişkinin potansiyeline işaret etmektedir.
TRIPADVISOR KULLANICILARININ TÜRKÇE VE İNGİLİZCE YORUMLARI KAPSAMINDA DUYGU ANALİZİ YÖNTEMLERİNİN KARŞILAŞTIRMALI ANALİZİ
Authors: POLAT Hıdır , AĞCA Yılmaz
Published: July 2022

Araştırmanın amacı, TripAdvisor kullanıcılarının Türkçe ve İngilizce yorumlarındaki duygusal eğilimlerin ortaya çıkarılması ve sınıflandırılmasında kullanılan duygu analizi yöntemlerini karşılaştırmaktır. Amaç kapsamında makine öğrenme yöntemlerinden Decision Tree, Random Forest gibi sınıflandırma algoritmaları kullanılmıştır. Nicel araştırma özelliği gösteren bu çalışma kapsamında veriler, TripAdvisor turizm portalından web kazıma tekniği ile elde edilmiştir. Amaçsal örnekleme yönteminin benimsendiği bu çalışmada verilerin analiz edilmesi sürecinde duygu analizi yöntemi kullanılmıştır. Veri analiz sürecinde açık kaynak kodlu KNİME veri madenciliği programından yararlanılmıştır. Araştırma neticesinde makine öğrenme algortimalarının sözlük tabanlı analize göre daha etkin sınıflandırma gerçekleştirdiği görülmüştür. Ayrıca makine öğrenme algortimaları sınıflandırma aşamasında Türkçe dilindeki yorumlarda daha başarılı sonuçlar üretmiştir.