bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of myocardial revascularization and endpoints after a 1-year follow-up of patients with acute and chronic coronary artery disease, depending on diabetes presence
Authors: Mamedov M. N. , Mardanov B. U. , Kokozheva M. A. , Shukurov F. B. , Akhundova H. R. , Kutsenko V. A.
Published: November 2022

Aim. To analyze myocardial revascularization in patients with acute and chronic coronary artery disease (CAD) and with different glycemic status, as well as to evaluate complications after a 1-year follow-up.

Material and methods. This prospective comparative clinical study included 202 patients of both sexes with acute and chronic coronary artery disease. Depending on the glycemic status and CAD type, the patients were divided into four groups: acute CAD and type 2 diabetes (T2D); acute CAD without T2D (control group); chronic CAD and T2D; chronic CAD without DM2 (control group). Depending on the clinical condition and the results of coronary angiography, patients underwent various types of myocardial revascularization: balloon angioplasty without stenting, stenting, coronary artery bypass grafting, stenting + coronary artery bypass grafting. One year after discharge, all patients were contacted to evaluate complications and endpoints, which included recurrent myocardial infarction, cerebrovascular accident, readmission, revascularization, and death. Total indicator of endpoints was assessed.

Results. Up to 80% of patients with acute and chronic CAD, regardless of glycemic status, underwent revascularization, mainly stenting. The prevalence of stenting among persons without T2D with acute and chronic CAD was significantly higher compared with patients with T2D. The absolute number of patients with coronary artery bypass grafting, including in combination with stenting, was higher in the T2D groups. In groups without T2D, the number of patients with one stent was 2-2,5 times higher compared to groups with T2D — acute CAD (p=0,041) and chronic CAD (p=0,017). The prevalence of implantation of ≥2 stents did not differ between the groups. Within 1 year after discharge, there were more hospitalizations and reoperations among people with acute and chronic CAD and T2D. The groups did not differ in the number of non-fatal and fatal complications, although the absolute numbers of these indicators were higher in patients with T2D. The total number of endpoints in T2D people, regardless of the CAD type, were 2 times higher compared to the corresponding control groups (p<0,001).

Conclusion. Most patients with acute and chronic CAD, regardless of glycemic status, underwent myocardial revascularization. In patients without T2D, stenting prevailed, most often of one coronary artery. Patients with T2D, along with stenting, underwent coronary bypass grafting, as well as a combination of these two procedures. After a year of follow-up, the number of complications in patients with T2D was 2 times higher compared to patients without type 2 diabetes, which emphasizes the importance of secondary prevention, including complex drug treatment.
Patient safety as a global health priority
Authors: Kim O. T.
Published: November 2022

Patient safety is a discipline that has arisen in response to the increasing complexity of health care delivery and the associated increase in patient harm. Adverse health care events are a serious problem, causing significant harm to the patient and increasing health care costs. The World Health Organization has identified patient safety as one of the key priorities for world health. The current review presents the historical background that led to the formation of the discipline of patient safety, the determinants of adverse events in medical practice, and the main tools for dealing with them.
VENTILATION SYSTEMS ENHANCEMENT IN SEMICONFINED AND CONFINED ROOMS USING STRAIGHT LOBED GRILLES
Authors: Bouasria S. , Bordjane Mustapha , Boualem Khadidja , Azzi A. , Mahi A.
Published: November 2022

This study presents a numerical investigation of flow behavior of a turbulent impinging jet in semiconfined and confined rooms using computing code ANSYS computational fluid dynamics. The lobed grille is proposed as a novel air diffuser design in order to develop air distribution inside the room. A comparison of the different types of diffuser geometry (elliptical, rectangular, and lobed grids) is carried out. Different discharge heights (0.3 m, 0.6 m, and 0.9 m) are taken into account. The effect of jet designs on thermal confort is investigated also. The validation results show a good agreement with the experimental data found in the literature. The flow behavior and thermal characteristics of the three designs are presented. The results show that lobed grilles enhance the ventilation systems for both semiconfined and confined rooms.
Cold Atmospheric Plasma Benefits after a Biopsy of the Gingiva and Palate: A Case Series
Authors: Ibáñez-Mancera Norma Guadalupe , López-Callejas Régulo , Toral-Rizo Víctor Hugo , Méndez Benjamín Gonzalo Rodríguez , Eguíluz Rosendo Peña , Lara-Carrillo Edith , Cabrera Antonio Mercado , Alvarado Raúl Valencia
Published: November 2022

When an oral biopsy is performed, wound healing depends on the formation of blood clots that resist mechanical forces. Mainly, when the biopsy is performed in the gingiva and palate area, the wounds are not easy to suture due to the type of tissue or area in which it is located. In this work, ten patients over 18 years of age with lesions located on the palate and gingiva required an excisional biopsy. A needle-type reactor powered by a radio frequency (RF) source was used to generate cold atmospheric plasma (CAP) for the healing wound. After placing the tip of the reactor on the wound after performing the biopsy, the CAP was applied to the wound through scanning. The time it took for the wound to heal after the biopsy was recorded in days. The wound achieved clinical repair time between one and seven days, where none of the patients undergoing treatment with CAP showed adverse effects. Significant tissue regeneration time was reduced, with an average of four days, without infection and absence of postsurgical pain, resulting in the almost immediate recovery of oral functions.
Safety management of offshore structures: overview
Authors: Houri Ausamah AL , Sadeghi Kabir
Published: November 2022

Safety management is a highly crucial process implemented in offshore structures for meeting safety criteria by eliminating potential risks. Accordingly, safety indicators are utilised to monitor systems and assess safety performance by meeting specific, measurable, achievable, relevant, timely, evaluated and reviewed (Smarter) criteria. Partly, the historical development of reliability and risk assessment methods is extensively discussed along with their advantages and disadvantages. Therefore, this paper focuses on the review of safety-management processes and their elements, including safety indicators, and it also discusses the process of optimising maintenance strategies using reliability and risk assessment approaches for offshore structures. The results in this paper show that utilising Smarter criteria for monitoring and evaluating the safety performance of offshore structures produced the most adequate safety system. For instance, the safety performance evaluation framework displayed functionality for benchmarking and constant enhancement of Malaysian offshore oil and gas platforms by conducting a comparison between 14 safety factors using a scoring system to determine fully the mechanisms and interactions of the factors with safety performance. Lastly, safety performance is established as a reference for the improvement of safety practices in offshore structures where the risk indicator system can provide a scientific benchmark for risk mitigation and investment decisions.
Assessment of Berezkinskoye ore field prospectivity using Micromine software
Authors: Bosikov I. I. , Klyuev R. V.
Published: November 2022

The use of modern computer aided methods, in particular the use of the Micromine software, is an important part of the integrated research for the determination of deposit prospects for various ores. The paper is devoted to the analysis of prospects and estimation of reserves for open-pit and underground mining in the Berezkinskoye ore field. For this purpose, silver reserves were determined as the principal valuable component. The deposit balance reserves were estimated separately for all types of ores in the optimal open pit envelope adopted in the final mining feasibility study (FS of permanent exploration conditions for ore extraction). To vectorize and verify the geological information entered into the database, graphical materials in the form of cross-sections and plans with the corresponding borehole database were georeferenced using the Micromine software. The final inspection was carried out to ensure that the sample depth information entered was consistent with the excavation depth. The database contains information on the location of boreholes and trenches, the design of boreholes, the spatial positioning of the boreholes/trenches axes, the data of sample assays for silver and copper. For underground mining, the delineation of ore bodies was carried out based on the cross-sections identified in the boreholes at a cut-off grade of 10.7 g/t, taking into account the orientation of geological structures. Reliability of the ore bodies delineation was verified in a Micromine three-dimensional model. For open-pit mining, the position of small ore bodies may be clarified by operational exploration with possible subsequent upgrading their reserve categories. The wireframe model of ore zones and bodies was constructed using the outlines obtained by the developed methodology. A wireframe model of faults was based on the Berezkinsky area plans and cross-sections. The construction of the fault wireframe model was performed in several steps. Application of modern geoinformation system (GIS) technologies makes it possible to qualitatively assess the prospects and estimate the reserves at the deposits. The Berezkinskoye deposit ore material composition, metallurgical properties, hydrogeological and geotechnical features were investigated.
Nature of radioactivity of quarry drainage waters in the Novosibirsk region
Authors: Derkachev A. S. , Maksimova A. A. , Novikov D. A. , Dultsev F. F. , Sukhorukova A. F. , Chernykh A. V. , Khvashchevskaya A. A.
Published: November 2022

This study is relevant for obtaining the first geochemical data (including information on radionuclides) on the drainage waters of developed and flooded quarries in the eastern areas of the Novosibirsk Region. The objective of the study was to identify the features of the chemical composition of drainage waters (a wide range of chemical elements from Li to U). The study was carried out by titrimetry, ion chromatography and mass spectrometry with inductively coupled plasma in a laboratory setting at the Hydrogeochemical Problem Research Laboratory (PNIL GGH) of the Engineering School of Natural Resources of Tomsk Polytechnic University (IShPR TPU). Measurements of 222Rn in waters were carried out at the Alfarad Plus facility of the Laboratory of Siberian Sedimentary Basins Hydrogeology of the A. A. Trofimuk Institute of Petroleum Geology and Geophysics, Siberian Branch of the Russian Academy of Sciences (INGG SB RAS). The data were divided into homogeneous geochemical populations using the coefficients Ca / Na, Ca/ Mg, Ca / Si, Mg/ Si, Na / Si. The chemical composition of the studied objects was found to be highly diverse. The dominant waters have the chemical formula SO4-HCO3 / Na-Mg-Ca with a TDS (total dissolved solids) of 400 to 700 mg/dm3. Three geochemical groups of waters were identified. The first is represented by drainage waters of the developed rubble stone quarries, the second includes facilities of the Gorlovka coal basin, and the third refers to abandoned flooded quarries. The first group is characterized by oxidizing conditions with Eh varying over a wide range from +84.6 to +261.0 mV, pH from 6.9 to 8.6, and O2dissoived from 3.43 to 14.39 mg/dm3. The radionuclide concentrations are (mg/dm3): 238U 9.30 • 10-3 - 1,40; 232Th 1,00 • 10-6 - 2,16 • 10-3; 222Rn activity varies from 1 to 572.5 Bq/dm3. The 232Th / 238U ratio ranges from 4.20 • 10-5 to 2.69 • 10-3 with an average of 8.40 • 10-4. The second group has a smaller Eh variation range of +133.2 to +199.6 mV, pH from 7.5 to 8.5, and O2dissolved from 6.81 to 10.43 mg/dm3. The radionuclide concentrations vary in the following ranges (mg/dm3): 238U 2.26 • 10-3 - 2.90 • 10-2; 232Th 7.5 • 10-6 - 5.57 • 10-4. The 232Th / 238U ratio ranges from 8.37 • 10-4 to 4.80 • 10-2 at an average of 9.54 • 10-3. The third group is also characterized by an oxidizingizing geochemical environment with Eh +131.3 - +250.0 mV, pH from 6.9 to 8.8 and O2dissolved from 4.00 to 16.59 mg/dm3. The radionuclide concentrations are (mg/dm3): 238U 3.00 • 10-4 - 2.74 • 10-2; 232Th 1.65 • 10-6 - 1.15 • 10-5; 222Rn activity varies from 2 to 31 Bq/dm3. The 232Th/ 238U ratio ranges from 2.36 • 10-4 to 1.02 • 10-3 at an average of 6.25 • 10-4. Overall, the 232Th / 238U ratio of the studied waters indicates their uranium nature of radioactivity. The data obtained indicate a slight impact of the drainage water discharge from the abandoned quarries on the environment.
Impact of knowledge, community attachment, and government trust on residents’ impact perceptions of and their support for a mega-event bidding
Authors:   The Tourism Sciences Society Of Korea, Lee Sang-Ho , Anh Sun-Young
Published: November 2022

This study was designed considering the limitations of social exchange theory, which assumes that external economic compensation is likely to motivate participation in resource exchanges. This study examined the effects of knowledge, community attachment, and government trust on exchange relationships under the assumption that rational and reciprocal exchange relationships can supplement the limitations of social exchange theory. The final test utilized 453 questionnaires gathered from local residents in preparation for the Busan World Expo. The following are the results: First, the more negative effects residents perceived, the less likely they were to oppose the Expo bid. Second, this study found that knowledge, community attachment, and government trust can enhance perceived positive impacts and influence positive impacts on Expo bid support. Despite the lack of statistical significance between these three variables, this study suggests that they may contribute to mitigating perceived negative impacts, which could be interpreted as a hint to encourage support for the Expo bid. This study concludes, based on these findings, that knowledge, community attachment, and government trust are necessary conditions for establishing a rational and reciprocal exchange relationship. Some strategies for increasing knowledge and trust in government are also proposed, such as providing objective information based on the Expo's functions and roles rather than biased public relations focusing on economic impacts, ensuring residents' participation in the Expo bidding process as a whole, and expanding private sector
Inbound tourists forecasting after COVID-19: Using intervention ARIMA analysis and tourism resilience
Authors:   The Tourism Sciences Society Of Korea, Kim Dohoon , Lim Changsik , Kim Nam-Jo
Published: November 2022

Predicting changes in the tourism industry following COVID-19 is a crucial task. Using an intervention ARIMA model that can compensate for external shocks such as COVID-19, this study forecasts the demand for inbound tourists visiting South Korea. Specifically, this study evaluates tourism's resilience in the aftermath of SARS and MERS. In addition, three recovery scenarios for forecasting tourism demand were presented, reflecting the resilience of the tourism industry. The first scenario assumes that COVID-19 is prolonged; in this case, the number of monthly inbound tourists is projected to remain stable between 100,000 and 130,000. The second scenario assumes the recovery rate of inbound tourists following the end of SARS, with 1.6 million visitors anticipated in February 2023. The third scenario assumes the recovery rate of inbound tourists after MERS has come to an end, with 2 million visitors anticipated in February 2023. Therefore, if COVID-19 is over, the trend of inbound tourists will return to pre-outbreak levels within two to six months. This study has academic significance because the intervention ARIMA model has the high prediction accuracy noted in prior research. In addition, it is significant because it is one of the only few tourism studies to conduct a quantitative study on tourism resilience after a disaster. Also, it can be helpful to policy-makers and tourism-related businesses in that it can present an empirical analysis system and provide objective data.
Superheavy elements
Authors:   Institute of Automation and Electrometry of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Yatsenko Aleksey S.
Published: November 2022

The article presents the main stages in the development of the doctrine of elements with a large nuclear charge and their place in the periodic table.
Business as a source of the recruitment of high-ranking officials of Russian federal economic ministries
Authors: Tev Denis
Published: November 2022

The article analyzes the role of business as a source of the recruitment of high-ranking officials of the economic ministries of the Russian government. The empirical basis of the study is a biographical database of 225 deputy ministers and directors of departments in eight ministries. The study demonstrated that although administrative professionalization is the most pronounced characteristic of officials’ careers, economic ministries are quite dependent on business as a channel for recruitment of their top executives, which, in this sense, has the features of a “new public management” bureaucracy. Business serves as the main supplier of senior staff for economic ministries outside the administrative realm, while large state-owned companies belonging to sectors supervised by ministries play a particularly significant role. Business experience is found more often at the highest level of the administrative hierarchy, particularly among deputy ministers. Interdepartmental differences are also significant: there are ministries with a pronounced presence of people from business, for example, the Ministry of Agriculture. In some ministries, the presence of intersections between ministers and their subordinates in the course of a business career preceding the current position is noticeable, which may indicate the importance of patrimonial recruitment based on personal loyalty or patron-client relations. The plutocratic recruitment of executives, especially noticeable in a number of ministries, probably puts overrepresented companies and industries in a privileged position in the policy-making and implementation process, thereby forming a kind of administrative bias in their favor.
Facultative Groups, Invisible Individuals: The Transformation of Social Relations in the New Technological Reality
Authors: Khestanov Rouslan , Suvalko Aleksander
Published: November 2022

The article aims to propose an alternative approach to the analysis of the social effects of digitalization. It was, by and large, intended to solve two problems; first, to assess the epistemological potential and limitations of existing theories and approaches, and second, it was to do what Luhmann, following Spencer Brown, called re-entry, to discover the blind spots of these theories, those differences that lead to the unrecognizable, the background, and the reduced, and then to try to re-enter the main theoretical concepts. Re-entry is easiest to accomplish with the new empirical material offered in this article. The study include the following results: 1) proposing a reactualization of Gordon Pask’s concept of “aesthetically charged environments” as a powerful analytical tool for social and digital communications; 2) an empirical and theoretical justification for the irrelevance of using the concept of “communities” in the context of digital practices research and replacing it with the concept of “facultative groups”; and 3) the fixation and description, on the basis of field research, of new forms of digital behavior that are inevitable reactions to the coercive or manipulative nature of digital regimes, which are expressed in the zero activity of advanced users, in the emerging digital ethic of absence, and in the development of new forms of self-discipline.
The philosophy of travel, communication with locality, and ‘landscape analytics’
Authors: Nemtsev Mikhail
Published: November 2022

Philosophical discussions about travel can easily turn into an analysis of the thinking and self-consciousness of travelers. However, the philosophy of travel should not be distracted from the locality with its materiality aspects. The essential feature of travel is that it implies an affective interaction with the terrain. The interaction can be understood as a special kind of communication Therefore it might be taken as the empirical basis for understanding travel not only as a research method, but also as a method of self-knowledge. The article discusses a collection of papers where such an experience of using travel in psychotherapy is developed in theory and conceived as a field test. This extensive understanding of the “journey” allows us to rethink the role of affects in the study of cultural landscapes. They turn out to be able to show a kind of activity, addressing travelers, and producing some personally valuable experiences (for example, the affect of topophilia).
Ontological security in international relations: on the mechanics of appropriation of territories inside the consciousness of nations
Authors: Kusliy Petr
Published: November 2022

Book review: Ejdus F. Crisis and Ontological Insecurity. Serbia’s Anxiety over Kosovo’s Secession (Cham: Springer Nature Switzerland AG, 2020).
Nutrition cycles in sessile oak (Quercus petraea Liebl.), Norway spruce (Picea abies L.Karst) and European beech (Fagus sylvatica L.) stands from Central Romania
Authors: Raluca-Elena Enescu , Alexandru Liviu Ciuvăț , Lucian Dincă , Carmen Iacoban , Elena Deleanu , Cristian Anghelus
Published: November 2022

In Romania, the sessile oak is the widest spread species of all native oak species, forming a lower story of vegetation. The European beech and Norway spruce cover 50% of the Romanian forest area. The purpose of this study was to analyze the variability of the leaf nutrients, as well as of the soil nutrients, for sessile oak, Norway spruce and European beech stands situated under different site conditions. The studied sites are located in the southern part of the Carpathian Mountains at altitudes varying from 600 m to 1300 m. Leaves samples were collected from twenty sessile oak trees, in three moments during the growing season. The same eight elements in total form were determined for soil and leave too: N, P, K, Ca, Mg, Fe, Cu and Zn. Leaves samples for beech and spruce were collected in the II Level Intensive Monitoring Grid of the ICP Forests Programme. The paper focuses on the seasonal concentration variation of eight macro elements in leaves and the correlations between the concentration of the macro elements in soil and litter. In addition, the study highlighted the degree of influence exerted by some soil properties on the foliar concentration of nutrients (through multiple regressions). The obtained results show different mobility of the elements and a greater variability was noticed in the case of certain elements. The same three soil properties were noticed to influence the foliar nitrogen concentration.
Evaluation of Readiness for Interprofessional Learning of students from the College of Pharmacy and the College of Nursing at a University
Authors:   The Pharmaceutical Society Of Korea, Kim Joo Hui , Kim Seong-Ok
Published: November 2022

This study was examined to evaluate readiness for interprofessional learning of students from the College of Pharmacy and the College of Nursing at a university. A cross-sectional structured survey was used to compare the readiness for interprofessional learning between different departments and by the experience of interprofessional education. As a survey questionnaire, the Korean version of readiness for interprofessional learning Scale (RIPLS) included 19 items. The subjects consisted of 76 students (20 nursing students with IPE experience, 33 pharmacy students with IPE experience, and 26 pharmacy students without IPE experience) enrolled in 2021. The response rate was 41.6%. The scores of readiness for interprofessional learning in nursing students were significantly higher than pharmacy students (p<0.05). The scores of readiness for interprofessional learning in pharmacy students without IPE experience were significantly higher than pharmacy students with IPE experience (p<0.05). Five sub-items in the teamwork and collaboration categories of RIPLS had a high score of over 4 points. An effective IPE program suitable for the educational field in Korea needs to be developed through additional research on IPE class content, essential skills, and learning methods in pharmaceutical education.
Development of Enzalutamide Solid Dispersion Loaded Tablet with Enhanced Solubility
Authors:   The Pharmaceutical Society Of Korea, Lee Jeong Gyun , Lee Su Min , Yun Seo Wan , Kim Kyeong Soo
Published: November 2022

The objective of this study was to develop a novel enzalutamide tablet formulation with enhanced solubility and bioavailability, and inhibited recrystallization. Kollidon VA64 was selected as a soluble polymer for preparing enzalutamide solid dispersions. Solid dispersions with different enzalutamide to Kollidon VA64 weight ratios were prepared via solvent evaporation method. The enzalutamide solid dispersion consisting of enzalutamide and Kollidon VA64 at a weight ratio of 1:1, exhibited an excellent dissolution rate and potent inhibition of recrystallization. Enzalutamide solid dispersions were characterized by scanning electron microscopy, powder X-ray diffractometry, differential scanning calorimetry, and in vitro dissolution studies. The 1:1 solid dispersion exhibited excellent productivity, an elevated dissolution rate, and recrystallization inhibition. Therefore, enzalutamide solid dispersion loaded tablets were prepared and their dissolution was evaluated compared to a commercial product (Xtandi® soft capsule). The selected tablet formulation containing enzalutamide solid dispersion exhibited a higher dissolution rate in pH 1.0 solution than did the Xtandi® soft capsule, and prevented recrystallization of the enzalutamide. This research suggests that enzalutamide-containing solid dispersion tablets could be the most effective method to date for improving the dosing compliance of Xtandi® soft capsules, improving the dissolution rate of enzalutamide, and preventing recrystallization.
Steps for setup of AWS organization, S3 data storage, and EC2 computing for using Python notebooks v1
Authors: J. Pollak Daniel
Published: November 2022

With the oncoming age of big data, biologists are encountering more use cases for cloud-based computing to streamline data processing and storage. Unfortunately, cloud platforms are difficult to learn, and there are few resources geared towards biologists for demystifying them. We have developed a guide for experimental biologists to set up cloud processing on Amazon Web Services to cheaply outsource data processing and storage. Here we provide a guide on setting up a computing environment in the cloud and showcase examples of using Python and Julia programming languages. We present example calcium imaging data in the zebrafish brain and corresponding analysis using suite2p software. Tools for management of users and budgets are discussed in the protocol. Following this guide should help researchers even with limited programming experience to get started or move existing coding infrastructure into the cloud environment.
Programa de Intervención #aquiproubullying en Educación Secundaria Obligatoria. Resultados de un Estudio Preliminar.
Authors: Mercader Rovira Albert , Cabrera Leopoldo , Solé Cases Silvia
Published: November 2022

El bullying y el ciberbullying son fenómenos que aparecen habitualmente en los centros de enseñanza y que provocan problemas físicos, emocionales y conductuales en las víctimas. Un centro público de Barcelona con alumnado de la Enseñanza Secundaria Obligatoria (ESO) implementó el programa #aquiproubullying propuesto por la Generalidad de Cataluña y quiso comprobar el efecto que tenía en la percepción de su alumnado (N=342) antes y después de la intervención con los cuestionarios EBIPQ (bullying) y ECIPQ (ciberbullying). Se aplicó un diseño cuasi-experimental con una variable independiente (VI), la intervención educativa; un diseño descriptivo para estudiar las puntuaciones de los cuestionarios EBIPQ y ECIPQ y un diseño asociativo para estudiar las relaciones entre las variables. La intervención no redujo la percepción de bullying aunque se detectó una reducción de la agresividad en ciberbullying entre el alumnado que pasó de segundo a tercero de ESO. Además, se encontraron asociaciones entre conductas victimizantes en bullying y ciberbullying y entre victimización y agresividad. Los autores apuntan la necesidad de mantener estos programas educativos aunque los datos no corroboren la efectividad plena a corto plazo en todas las conductas de bullying y ciberbullying.
Concepciones del Profesorado acerca de los Elementos Curriculares que Presentan los Libros de Texto y los Materiales de Elaboración Docente
Authors: Trave Gonzalez Gabriel , Soto Rosales Antonio , Travé González Gabriel
Published: November 2022

El estudio representa una contribución en el campo de las concepciones y prácticas reflexionadas del profesorado de Educación Infantil, Primaria y Secundaria en torno a los materiales curriculares de Ciencias Naturales y Sociales. Se ha indagado acerca de las concepciones docentes relacionadas con los elementos curriculares que proponen los libros de texto y los materiales de elaboración docente. Se utiliza una metodología mixta a partir de instrumentos de encuesta y entrevista con una muestra de 962 docentes andaluces. Entre los resultados se observa que existe homogeneidad entre las concepciones del profesorado de Educación Infantil y Primaria en torno a elementos curriculares que presentan los libros de texto y los materiales de elaboración docente, frente a la opinión del profesorado de Secundaria. Sin embargo, se pone de manifiesto el consenso de los tres grupos de profesorado en torno a la necesidad de complementar los libros de texto con otros materiales para enriquecer los procesos de enseñanza/ aprendizaje. Las conclusiones del estudio evidencian la necesidad de potenciar la competencia curricular del profesorado y apoyar el diseño, desarrollo y evaluación de materiales curriculares experimentados en la práctica de aula.
Langerhans cell histiocytosis in adults: literature review
Authors: Potapenko V. G. , Baykov V. V. , Zinchenko A. V. , Potikhonova N. A.
Published: November 2022

Langerhans cells histiocytosis is a variant of malignant histiocytosis. The course and symptoms vary. patients with localized forms have a better prognosis, because local therapy is effective. patients with multifocal forms of histiocytosis receive systemic drug therapy, which cures some of the patients. This review provides up-to-date data about typical presentation of the organ involvement, diagnosis, course and therapy of various forms of Langerhans cells histiocytosis.
Influence of nutritional support on tolerability and results of treatment in patients with newly diagnosed hemoblastoses received program chemotherapy
Authors: Shen’ N. P. , Minin A. S. , Gaydym E. Yu. , Ksenzova T. I.
Published: November 2022

Background. Nutritional deficiency in malignant hematological diseases is a common condition that contributes to a decrease in functionality, tolerability of anticancer treatment and patient quality of life, and an increase in mortality rates. Often, malnutrition develops even before the start of anticancer treatment or during therapy and often remains unrecognized up to pronounced stages. despite the obvious importance of assessing and correcting the nutritional status in patients with hematological malignancies, this problem remains poorly understood.Aim. To evaluate the effect of nutritional support on the tolerability and results of treatment in patients with hemoblastoses.Materials and methods. The study included 40 patients with newly diagnosed hemoblastoses with nutritional deficiency or at risk of its development, who received program chemotherapy. patients were randomized into 2 comparable groups: in the main group (n = 20) patients received 2–3 bottles of Nutridrink compact protein mixture per day for 30 days, in the control group (n = 20) they ate at their own discretion without the use of additional enteral nutrition.Results. Comparative results of laboratory monitoring showed a significant increase in albumin levels in the main group compared with the control group (p <0.01). In the main group, less severe gastrointestinal toxicity of systemic anticancer therapy was observed: a tendency to a lower incidence of diarrhea and mucositis, a statistically significant reduction in the frequency of constipation, and a significant 2.8-fold decrease in the frequency of taste changes (25 % versus 70 %). Assessment of hematological toxicity showed that pancytopenia persisted in the control group (decrease in leukocytes, erythrocytes, hemoglobin, hematocrit and platelets levels), which was absent in the main group; leukocytes, hemoglobin, hematocrit, platelets and eosinophils were statistically significantly lower compared to the main group.Conclusion. The use of the Nutridrink compact protein mixture within 30 days from the start of treatment in patients with newly diagnosed hemablastoses contributed to an increase in albumin level, and reduced the incidence of gastrointestinal and hematological toxicity during systemic antitumor therapy.
Tumour lysis syndrome: modern aspects of the problem
Authors: Matinyan N. V. , Valiev T. T. , Martynov L. A. , Akimov V. P. , Kovaleva E. A. , Buidenok Yu. V.
Published: November 2022

Background. Acute tumor lysis syndrome (ATLS) complicates the treatment of highly aggressive leukemias and lymphomas in children and leads to death in 21.4 % of severe cases. ATLS is based on the death of tumor cells, so the volume of decay products exceeds the excretory capacity of the kidneys. The ATLS risk group includes patients with acute lymphoblastic leukemia accompanied by hyperleukocytosis (above 100 × 109/L) and non-Hodgkin’s lymphomas with a large tumor mass (stage III–Iv of the disease). The development of acute renal and then multiple organ failure require intensive monitoring of ATLS clinical and biochemical markers and the development of optimal patient management tactics jointly by an intensive care physician and a pediatric oncologist-hematologist.Aim. To summarize the literature and our own clinical experience in the diagnosis and treatment of ATLS in pediatric oncohematology.Materials and methods. The literature data on the diagnosis and treatment of ATLS in children with oncohematological diseases were analyzed. Summarized own clinical experience from January 2009 to January 2022.Results. Of 379 patients with acute lymphoblastic leukemia and non-Hodgkin’s lymphomas, who are at risk for developing ATLS, 350 (93.4 %) patients underwent conservative ATLS therapy, of which in 31 (8.8 %) cases, hemodiafiltration was required to eliminate tumor decay products. The average number of hemodiafiltration procedures is 3 (from 1 to 15). Nevertheless, despite the whole range of therapeutic measures, the addition of infectious and multiple organ complications caused death in 7 (22.6 %) of 31 patients. Most (5 out of 7) fatal cases occurred between 2009 and 2013, and the number of lethal cases because of ATLS from 2014 to 2022 years were only 2. In 24 (77.4 %) patients, the signs of ATLS were successfully managed, the patients continued antitumor treatment. when observing patients for 6 years (from 7 months to 13 years), there were no signs of disease relapse, as well as renal dysfunction.Conclusion. prevention and treatment of ATLS, including cytoreductive prephase, infusion therapy, allopurinol and rasburicase, and in case of ineffectiveness, hemodiafiltration is the basis of modern intensive therapy for hematological malignancies in children. Additional study of the pathogenetic mechanisms of ATLS development, identification of key targets of drug therapy, and a multidisciplinary approach in the treatment of an extremely unfavorable group of oncohematological patients with advanced stages of the tumor process are possible components for further increasing the effectiveness of ATLS therapy.
Pharmacoeconomic analysis of fixed-duration targeted therapy regimens for chronic lymphocytic leukemia compared with therapy used until progression or intolerable toxicity
Authors: Kasimova A. R. , Kolbin A. S. , Proskurin M. A. , Balykina Yu. E.
Published: November 2022

Background. Chronic lymphocytic leukemia (CLL) is a b-cell tumor of small b-lymphocytes. In CLL, significant lymphocytosis (5000 monoclonal b-lymphocytes) is observed in the blood, there are no morphological signs of bone marrow involvement. The 2020 Russian Clinical Guidelines “Chronic lymphocytic leukemia/Small lymphocyte lymphoma” approved several main chemotherapy regimens for the treatment of CLL patients.Aim. To perform a pharmacoeconomic analysis of the feasibility of fixed therapy regimens based on venetoclax in comparison with other targeted drugs registered in Russia, from the class of bruton kinase inhibitors, used until CLL progression or unacceptable toxicity.Materials and methods. A list of direct costs in the health care system was compiled. To assess the change in the cost structure and budget impact analyze, 4 mathematical models were constructed from a health care system perspective. Model 1 analyzed the direct costs of the health care system over 5 years, without taking into account the addition of new patients to the model. At the beginning of the modeling, the patients were equally divided between the strategies; later, there was a natural withdrawal of patients from the cycle. Models 2–4 analyze the economic impact of increasing the proportion of venetoclax-based fixed regimens.Results. with venetoclax + rituximab and venetoclax + obinutuzumab combinations used in 65 % of new patients, a cost reduction of 6.97 % would be observed in 2nd year of the budget impact analysis. In the case of an increase in the use of venetoclax in combination with rituximab or obinutuzumab to 80 % for new patients in the 5th year of the budget impact analysis, direct costs will decrease by 31.17 %, to 9,077,299,932 rubles.Conclusion. Increasing the proportion of fixed-dose venetoclax-based combinations compared to regimens prior to CLL progression or unacceptable toxicity in all models demonstrates cost-effectiveness.
Priapism as the first symptom of chronic myeloid leukemia: literature review and own clinical case report
Authors: Pavlova T. Yu. , Valiev T. T.
Published: November 2022

Chronic myeloid leukemia is a ph-positive myeloproliferative disease, which is usually manifested by hyperleukocytosis and massive splenomegaly. Chronic myeloid leukemia is rare in childhood and adolescence, it accounts for 2 to 3 % of all leukemias cases. priapism is a rare manifestation of chronic myeloid leukemia and is an urgent urological condition that requires timely treatment to prevent long-term complications, in particular, erectile dysfunction.This review presents the literature information about priapism as the first sign of chronic myeloid leukemia, as well as the first description in the Russian literature of a clinical case of priapism in a 9-year-old patient with chronic myeloid leukemia.
Does Technology Thwart Gender Stereotypes? An Impression Formation-Based Examination of the Differential Influence of Technology across Gender and Messages
Authors: Luse Andy ,   Oklahoma State University, Townsend Anthony M. ,   Iowa State University, Mennecke Brian E. ,   Iowa State University
Published: November 2022

This research examines the relationship between gender, message sentiment, and technology use on the way that observers form impressions of others. Building on impression formation and gender stereotype research and theory, we develop a two-study research methodology for examining how impressions of technology users are formed. The results of our two studies indicate that technology use is an important component in impression formation, significantly inhibiting the effects of gender stereotyping, such that women and men are not evaluated differently based on their apparent competency in using technology nor on the content of their messaging. Our findings indicate that the use of technology subverts both the male and female stereotypes that observers normally engage.
Altering Electrical Features of LuFeO3 Compound Via Ir Doping into Fe Sites
Authors: POLAT Özgür
Published: November 2022

Three ceramic compounds, LuFeO3, LuFe0.95Ir0.05O3, and LuFe0.90Ir0.10O3, were fabricated via using solid-state reaction technique. Scanning electron microscopy (SEM) analyses have shown the porous nature of the samples. The loss-tan(δ) of Ir substituted compounds are less than the undoped sample at frequencies > 105 Hz. The impedance study has revealed the Ir substituted samples have higher impedance values. Z″ and M″ vs frequency plots unveiled the existence of a non-Debye relaxation with short-range migration of carriers in the examined compounds. It has been shown 5 mol % Ir substituted specimen holds the maximum resistivity at 100 0C. Scanning electron microscopy has been utilized to study surface morphology.
Singularities of the Ruled Surfaces According to RM Frame and Natural Lift Curves
Authors: KARACA Emel
Published: November 2022

In this study, the ruled surface generated by the natural lift curve in IR^3 is obtained by using the isomorphism between unit dual sphere, DS^2 and the subset of the tangent bundle of unit 2-sphere, T\bar{M}. Then, exploitting E. Study mapping and the isomorphism mentioned below, each natural lift curve on T\bar{M} is corresponded to the ruled surface in IR^3. Moreover, the singularities of this ruled surface are examined according to RM vectors and these ruled surfaces have been classified. Some examples are given to support the main results.
Influence of the Core Pillar Height on the Bandgap Characteristics of Piezoelectric Phononic Crystals with Ring-Shaped Grooves
Authors: KURUOĞLU Furkan
Published: November 2022

Dispersion profiles and surface acoustic wave attenuation characteristics of ring-shaped phononic crystals are investigated as a function of the core pillar height. Finite element method simulations are carried out for both band analyses and transmission spectra calculations. The results reveal that increasing core pillar height results in a decrement in the local resonance band frequency and the corresponding transmission peaks. The obtained dispersion profiles show that the phononic crystal bandgap also expands from 6 MHz to 11 MHz while the pillar height increases from 5 um to 7 um. Similar characteristics are also seen in the transmission spectra for the varying core pillar heights of the ring-shaped periodic grooves. In addition, surface acoustic wave attenuation competency depends on the core pillar height. The frequencies where the investigated phononic crystals are functional can be tuned by adjusting the core pillar height.
Nutritional interventions in the framework of a person-centered model of health care and geroprotection
Authors: Martyushev-Poklad Andrey V. , Yankevich Dmitry S. , Savitskaya Nataliya G. , Petrova Marina V.
Published: November 2022

The existing system of prevention of age-related diseases that focused on cohort-based risk factors shows insufficient effectiveness; thus, practicable methodology of health promotion compliant with the principles of P4 medicine, with a special focus on nutritional interventions, is needed. The study outlines an algorithm of nutritional interventions designed in accordance with the principles of person-centered organizational model of healthcare. The algorithm is based on the modern concept of exposome and its influence on the key mechanisms of accelerated aging and pathogenesis of age-related diseases. The proposed approach to personalized nutritional interventions is implemented in three steps: (1) the need for nutritional intervention is identified through the evaluation of the signs and symptoms of health impairment and accelerated aging that have very probable association with suboptimal nutrition, (2) individual exposome factors are evaluated as potential sources of health problems, and (3) first-line nutritional interventions are selected and implemented. The algorithm focused on eliminating the shortcomings of the diagnosis-centered organizational model of healthcare prevailing worldwide: to enable early detection of distress, use of the most effective and affordable interventions (diet and nutrition), and maximum involvement of the patient in health management. The algorithm bears a good potential of automation through decision support for patients regarding health. The use of original questionnaires and patient-centered data reduces the cost and expands the possibilities of scaling the algorithms of intervention. The algorithm can become the basis for the wide introduction of the principles of predictive, personalized, and participatory prevention of age-related diseases.
The impact of SARS-CoV-2 peptides on activation of NK cells
Authors: Ustiuzhanina Maria O. , Britanova Olga V. , Kovalenko Elena I.
Published: November 2022

BACKGROUND: NK cells, alone with T lymphocytes, have a high antiviral activity. Exploring the contribution of NK cells in fighting SARS-CoV-2 infection may promote the development of appropriate treatments for COVID-19. Previously, NK cell response was considered nonspecific, provided by a combination of signals from activating and inhibitory receptors. Currently, the existence of certain subpopulations of antigen-specific, or adaptive, NK cells has been shown.
AIM: To evaluate the functional response of NK cells induced by SARS-CoV-2 peptides.
MATERIALS AND METHODS: The functional response of NK cells to SARS-CoV-2 peptides was determined by their degranulation (surface CD107a expression) and IFN production levels, and by the activation degree (HLA-DR expression level). Volunteers who recovered from COVID-19 participated in the study, and immune cells from a healthy volunteer without SARS-CoV-2-specific antibodies were used as controls.
RESULTS: NK cells from individuals who had recovered from COVID-19, in contrast to a donor who had not been infected, showed a higher level of IFN production in response to SARS-CoV-2 peptides, compared with control samples. The level of degranulation of NK cells from donors previously infected with SARS-CoV-2 was higher than in the corresponding control. The proportion of activated NK cells obtained from recovered donors was also higher in samples stimulated with SARS-CoV-2 peptides.
CONCLUSIONS: We have demonstrated the activation of NK cells obtained from people who had previously recovered from COVID-19 in response to SARS-CoV-2 peptide antigens in cultures of peripheral mononuclear cells in vitro. This study reveals the possibility for further investigation of antigen-specific NK cells in COVID-19 disease. The use of such cells could help develop treatments for SARS-CoV-2 infection.