bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of the COVID-19 Lockdown on the Position-Specific Match Running Performance of Professional Football Players; Preliminary Observational Study
Authors: Sekulic Damir , Versic Sime , Decelis Andrew , Castro-Piñero Jose , Javorac Dejan , Dimitric Goran , Idrizovic Kemal , Jukic Igor , Modric Toni
Published: November 2021

The COVID-19 pandemic interrupted professional football in the 2019/2020 season, and football experts anticipate that the consequences of lockdown measures will negatively affect the physical performance of players once competition restarts. This study aimed to evaluate position-specific match running performance (MRP) to determine the effect of COVID-19 lockdowns on the physical performance of professional football players. Players’ MRPs (n = 124) were observed in matches before and after the COVID-19 lockdown in the 2019/2020 season of the highest level of national competition in Croatia and were classified according to player position: central defenders (CD; n = 42), fullbacks (FB; n = 20), midfielders (MF; n = 46), and forwards (FW; n = 16). The MRPs were measured using Global Positioning System, and included the total distance covered, low-intensity running (≤14.3 km/h), running (14.4–19.7 km/h), high-intensity running (≥19.8 km/h), total accelerations (>0.5 m/s2), high-intensity accelerations (>3 m/s2), total decelerations (less than –0.5 m/s2), and high-intensity decelerations (less than –3 m/s2). The results indicated that, in matches after the COVID-19 lockdown, (i) CDs and FBs featured lower running and high-intensity running (t-value: from 2.05 to 3.51; all p < 0.05; moderate to large effect sizes), (ii) MFs covered a greater distance in low-intensity running and achieved a lower number of total accelerations, and total and high-intensity decelerations (t-value: from –3.54 to 2.46; all p < 0.05, moderate to large effect sizes), and (iii) FWs featured lower high-intensity running (t-value = 2.66, p = 0.02, large effect size). These findings demonstrate that the physical performances of football players from the Croatian first division significantly decreased in matches after the COVID-19 lockdown. A combination of inadequate adaptation to football-specific match demands and a crowded schedule after the competition was restarted most likely resulted in such an effect.
The Effects of Sit-to-Stand Training Combined with Real-Time Visual Feedback on Strength, Balance, Gait Ability, and Quality of Life in Patients with Stroke: A Randomized Controlled Trial
Authors: Hyun Seung-Jun , Lee Jin , Lee Byoung-Hee
Published: November 2021

This study aimed to investigate the effects of lower limbs muscles’ strength, balance, walking, and quality of life through sit-to-stand training combined with real-time visual feedback (RVF-STS group) in patients with stroke and to compare the effects of classic sit-to-stand training (C-STS group). Thirty patients with stroke were randomly divided into two groups. The RVF-STS group received sit-to-stand training combined with real-time visual feedback using a Wii Balance Board (n = 15), and the C-STS group received classic sit-to-stand training (n = 15). All participants received training for 20 min once a day, 5 days a week for 6 weeks, and both groups underwent general physical therapy for 30 min before training. Before and after the training, the muscle strength of the hip flexor, abductor, and knee extensor were measured, and the Wii Balance Board was used to perform the center of pressure test and Berg Balance Scale to evaluate static and dynamic balance. Additionally, the 10 m walking test and the Timed Up and Go test were performed to evaluate gait function. The Stroke-Specific Quality of Life was used to measure the quality of life. The results showed that the lower extremity muscle strength, balance ability, walking ability, and quality of life of the RVF-STS group significantly improved in comparison of the pre- and post-differences (p < 0.05), and it also showed significant differences between groups (p < 0.05). This study showed that sit-to-stand training combined with real-time visual feedback was effective at improving the muscle strength of the lower extremities, balance, gait, and quality of life in patients with stroke. Therefore, repeating sit-to-stand training combined with real-time visual feedback could be used as an effective treatment method for patients with stroke.
Interrelationships of Economic Stressors, Mental Health Problems, Substance Use, and Intimate Partner Violence among Hispanic Emergency Department Patients: The Role of Language-Based Acculturation
Authors: Cunradi Carol B. , Caetano Raul , Ponicki William R. , Alter Harrison J.
Published: November 2021

We analyzed the interrelationships of economic stressors, mental health problems, substance use, and intimate partner violence (IPV) among a sample of Hispanic emergency department patients and probed if Spanish language preference, which may represent low acculturation and/or immigrant status, had a protective effect, in accordance with the Hispanic health paradox. Study participants (n = 520; 50% female; 71% Spanish speakers) provided cross-sectional survey data. Gender-stratified logistic regression models were estimated for mental health problems (PTSD, anxiety, depression), substance use (risky drinking, cannabis, illicit drug use), and IPV. Results showed that economic stressors were linked with mental health problems among men and women. Among men, PTSD was associated with greater odds of cannabis and illicit drug use. Men who used cannabis and illicit drugs were more likely to report IPV. Male Spanish speakers had lower odds of anxiety and cannabis use than English speakers. Female Spanish speakers had lower odds of substance use and IPV than English speakers. The protective effect of Spanish language preference on some mental health, substance use, and IPV outcomes was more pronounced among women. Future research should identify the mechanisms that underlie the protective effect of Spanish language preference and explore factors that contribute to the observed gender differences.
Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease
Authors: Kim Chaebin , Yousefian-Jazi Ali , Choi Seung-Hye , Chang Inyoung , Lee Junghee , Ryu Hoon
Published: November 2021

Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of CAG trinucleotide repeat located in the exon 1 of Huntingtin (HTT) gene in human chromosome 4. The HTT protein is ubiquitously expressed in the brain. Specifically, mutant HTT (mHTT) protein-mediated toxicity leads to a dramatic degeneration of the striatum among many regions of the brain. HD symptoms exhibit a major involuntary movement followed by cognitive and psychiatric dysfunctions. In this review, we address the conventional role of wild type HTT (wtHTT) and how mHTT protein disrupts the function of medium spiny neurons (MSNs). We also discuss how mHTT modulates epigenetic modifications and transcriptional pathways in MSNs. In addition, we define how non-cell autonomous pathways lead to damage and death of MSNs under HD pathological conditions. Lastly, we overview therapeutic approaches for HD. Together, understanding of precise neuropathological mechanisms of HD may improve therapeutic approaches to treat the onset and progression of HD.
Molecular Modeling Studies of N-phenylpyrimidine-4-amine Derivatives for Inhibiting FMS-like Tyrosine Kinase-3
Authors: Ghosh Suparna , Keretsu Seketoulie , Cho Seung Joo
Published: November 2021

Overexpression and frequent mutations in FMS-like tyrosine kinase-3 (FLT3) are considered risk factors for severe acute myeloid leukemia (AML). Hyperactive FLT3 induces premature activation of multiple intracellular signaling pathways, resulting in cell proliferation and anti-apoptosis. We conducted the computational modeling studies of 40 pyrimidine-4,6-diamine-based compounds by integrating docking, molecular dynamics, and three-dimensional structure–activity relationship (3D-QSAR). Molecular docking showed that K644, C694, F691, E692, N701, D829, and F830 are critical residues for the binding of ligands at the hydrophobic active site. Molecular dynamics (MD), together with Molecular Mechanics Poison–Boltzmann/Generalized Born Surface Area, i.e., MM-PB(GB)SA, and linear interaction energy (LIE) estimation, provided critical information on the stability and binding affinity of the selected docked compounds. The MD study suggested that the mutation in the gatekeeper residue F691 exhibited a lower binding affinity to the ligand. Although, the mutation in D835 in the activation loop did not exhibit any significant change in the binding energy to the most active compound. We developed the ligand-based comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models. CoMFA (q2 = 0.802, r2 = 0.983, and QF32 = 0.698) and CoMSIA (q2 = 0.725, r2 = 0.965 and QF32 = 0.668) established the structure–activity relationship (SAR) and showed a reasonable external predictive power. The contour maps from the CoMFA and CoMSIA models could explain valuable information about the favorable and unfavorable positions for chemical group substitution, which can increase or decrease the inhibitory activity of the compounds. In addition, we designed 30 novel compounds, and their predicted pIC50 values were assessed with the CoMSIA model, followed by the assessment of their physicochemical properties, bioavailability, and free energy calculation. The overall outcome could provide valuable information for designing and synthesizing more potent FLT3 inhibitors.
Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the MGMT Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set
Authors: Zappe Katja , Pirker Christine , Miedl Heidi , Schreiber Martin , Heffeter Petra , Pfeiler Georg , Hacker Stefan , Haslik Werner , Spiegl-Kreinecker Sabine , Cichna-Markl Margit
Published: November 2021

Due to its cost-efficiency, high resolution melting (HRM) analysis plays an important role in genotyping of candidate single nucleotide polymorphisms (SNPs). Studies indicate that HRM analysis is not only suitable for genotyping individual SNPs, but also allows genotyping of multiple SNPs in one and the same amplicon, although with limited discrimination power. By targeting the three C>T SNPs rs527559815, rs547832288, and rs16906252, located in the promoter of the O6-methylguanine-DNA methyltransferase (MGMT) gene within a distance of 45 bp, we investigated whether the discrimination power can be increased by coupling HRM analysis with pyrosequencing (PSQ). After optimizing polymerase chain reaction (PCR) conditions, PCR products subjected to HRM analysis could directly be used for PSQ. By analyzing oligodeoxynucleotide controls, representing the 36 theoretically possible variant combinations for diploid human cells (8 triple-homozygous, 12 double-homozygous, 12 double-heterozygous and 4 triple-heterozygous combinations), 34 out of the 36 variant combinations could be genotyped unambiguously by combined analysis of HRM and PSQ data, compared to 22 variant combinations by HRM analysis and 16 variant combinations by PSQ. Our approach was successfully applied to genotype stable cell lines of different origin, primary human tumor cell lines from glioma patients, and breast tissue samples.
Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Qβ Conjugates as a Vaccine Candidate
Authors: Zong Guanghui , Toonstra Christian , Yang Qiang , Zhang Roushu , Wang Lai-Xi
Published: November 2021

The broadly neutralizing antibody PG9 recognizes a unique glycopeptide epitope in the V1V2 domain of HIV-1 gp120 envelope glycoprotein. The present study describes the design, synthesis, and antibody-binding analysis of HIV-1 V1V2 glycopeptide-Qβ conjugates as a mimic of the proposed neutralizing epitope of PG9. The glycopeptides were synthesized using a highly efficient chemoenzymatic method. The alkyne-tagged glycopeptides were then conjugated to the recombinant bacteriophage (Qβ), a virus-like nanoparticle, through a click reaction. Antibody-binding analysis indicated that the synthetic glycoconjugates showed significantly enhanced affinity for antibody PG9 compared with the monomeric glycopeptides. It was also shown that the affinity of the Qβ-conjugates for antibody PG9 was dependent on the density of the glycopeptide antigen display. The glycopeptide-Qβ conjugates synthesized represent a promising candidate of HIV-1 vaccine.
Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis
Authors: Abuja Peter M. , Zatloukal Kurt , Denk Helmut
Published: November 2021

Understanding the pathomechanism of steatohepatitis (SH) is hampered by the difficulty of distinguishing between causes and consequences, by the broad spectrum of aetiologies that can produce the phenotype, and by the long time-span during which SH develops, often without clinical symptoms. We propose that SH develops in four phases with transitions: (i) priming lowers stress defence; (ii) triggering leads to acute damage; (iii) adaptation, possibly associated with cellular senescence, mitigates tissue damage, leads to the phenotype, and preserves liver function at a lower level; (iv) finally, senescence prevents neoplastic transformation but favours fibrosis (cirrhosis) and inflammation and further reduction in liver function. Escape from senescence eventually leads to hepatocellular carcinoma. This hypothesis for a pathomechanism of SH is supported by clinical and experimental observations. It allows organizing the various findings to uncover remaining gaps in our knowledge and, finally, to provide possible diagnostic and intervention strategies for each stage of SH development.
Comparative Genome Analysis of Genes Regulating Compound Inflorescences in Tomato
Authors: Yang Yahui , Yang Huanhuan , Tan Yinxiao , Zhao Tingting , Xu Xiangyang , Li Jingfu , Jiang Jingbin
Published: November 2021

Inflorescences are the main factor affecting fruit yield. The quantity and quality of inflorescences are closely related to fruit quality and yield. The presence of compound inflorescences in cherry tomatoes is well established, and it has been discovered by chance that compound racemes also exist in tomatoes. To explore the formation of compound inflorescences in tomato, transcriptome sequencing was performed on Moneymaker (MM) and Compound Inflorescence (CI) plants. In-florescences were collected in three periods (early, middle and late) in three replicates, for a total of 18 samples. Data analysis showed that the DEGs were most enriched in metabolic pathways and plant hormone signal transduction pathways. The DEGs were also enriched in the cell cycle pathway, photosynthesis pathway, carbon metabolism pathway and circadian rhythm pathway. We found that the FALSIFLORA (FA), COMPOUND INFLORESCENCE (S) and ANANTHA (AN) genes were involved in compound inflorescence development, not only revealing novel genes but also providing a rich theoretical basis for compound inflorescence development.
On the Importance of Pnictogen and Chalcogen Bonding Interactions in Supramolecular Catalysis
Authors: Frontera Antonio , Bauza Antonio
Published: November 2021

In this review, several examples of the application of pnictogen (Pn) (group 15) and chalcogen (Ch) bonding (group 16) interactions in organocatalytic processes are gathered, backed up with Molecular Electrostatic Potential surfaces of model systems. Despite the fact that the use of catalysts based on pnictogen and chalcogen bonding interactions is taking its first steps, it should be considered and used by the scientific community as a novel, promising tool in the field of organocatalysis.
The Laccase Gene Family Mediate Multi-Perspective Trade-Offs during Tea Plant (Camellia sinensis) Development and Defense Processes
Authors: Yu Yongchen , Xing Yuxian , Liu Fengjing , Zhang Xin , Li Xiwang , Zhang Jin , Sun Xiaoling
Published: November 2021

Laccase (LAC) plays important roles in different plant development and defense processes. In this study, we identified laccase genes (CsLACs) in Camellia sinensis cv ‘Longjing43′ cultivars, which were classified into six subclades. The expression patterns of CsLACs displayed significant spatiotemporal variations across different tissues and developmental stages. Most members in subclades II, IV and subclade I exhibited contrasting expression patterns during leaf development, consistent with a trade-off model for preferential expression in the early and late developmental stages. The extensive transcriptional changes of CsLACs under different phytohormone and herbivore treatment were observed and compared, with the expression of most genes in subclades I, II and III being downregulated but genes in subclades IV, V and VI being upregulated, suggesting a growth and defense trade-off model between these subclades. Taken together, our research reveal that CsLACs mediate multi-perspective trade-offs during tea plant development and defense processes and are involved in herbivore resistance in tea plants. More in-depth research of CsLACs upstream regulation and downstream targets mediating herbivore defense should be conducted in the future.
An Analytical and Numerical Detour for the Riemann Hypothesis
Authors: Riguidel Michel
Published: November 2021

From the functional equation F(s)=F(1−s) of Riemann’s zeta function, this article gives new insight into Hadamard’s product formula. The function S1(s)=d(lnF(s))/ds and its family of associated Sm functions, expressed as a sum of rational fractions, are interpreted as meromorphic functions whose poles are the poles and zeros of the F function. This family is a mathematical and numerical tool which makes it possible to estimate the value F(s) of the function at a point s=x+iy=x˙+½+iy in the critical strip S from a point 𝓈=½+iy on the critical line ℒ.Generating estimates Sm∗(s) of Sm(s) at a given point requires a large number of adjacent zeros, due to the slow convergence of the series. The process allows a numerical approach of the Riemann hypothesis (RH). The method can be extended to other meromorphic functions, in the neighborhood of isolated zeros, inspired by the Weierstraß canonical form. A final and brief comparison is made with the ζ and F functions over finite fields.
Metadata Schema for Folktales in the Mekong River Basin
Authors: Kwiecien Kanyarat , Chansanam Wirapong , Supnithi Thepchai , Chitiyaphol Jaturong , Tuamsuk Kulthida
Published: November 2021

The aim of this study was to analyze the content, context, and structure of folktales from the Mekong River Basin, and to develop a metadata schema for data description and folktale storage. The research was conducted using the MAAT metadata lifecycle model, which comprises the following four steps: (1) conducting an information content analysis; (2) creating metadata requirements, (3) developing a metadata schema; and (4) carrying out a metadata service and evaluation. The folktale analysis, based on Anne Gilliland’s information object analysis, revealed the following: (1) the folktale content consists of types of tales, and the morals, beliefs, and parts they incorporate; (2) the folktale context consists of and names distributors, characters, scenes, magical objects, ethnic groups, languages, countries, relationships between tales, and their sources; (3) the folktale structure includes verbal, non-verbal, and mixed forms. The metadata schema development adopted the functional requirements for bibliographic records concepts and existing metadata standards, resulting in metadata with the following 18 elements: identifier, title, creator, contributor, description, relation, language, medium, sources, date, rights, keyword, character, moral, ethnic group, motif, place, and country. The metadata elements were described using the categories: name, definition, format, example, and note.
Effectiveness of Entomopathogenic Fungi on Immature Stages and Feeding Performance of Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae) Larvae
Authors: Idrees Atif , Qadir Ziyad Abdul , Akutse Komivi Senyo , Afzal Ayesha , Hussain Mubasher , Islam Waqar , Waqas Muhammad Saad , Bamisile Bamisope Steve , Li Jun
Published: November 2021

Maize is a major staple crop in China, and the sustainable productivity of this primary crop has been recently threatened by fall armyworm (FAW), Spodoptera frugiperda, invasion. The five fungal isolates, Aspergillus sp. BM-3 and SE-2-1, Cladosporium tenuissimum SE-10, Penicillium citrinum CTD-24, and Beauveria bassiana ZK-5 were assessed for their efficacy in causing mortality against first to sixth instar eggs and neonate larvae seven days post-treatment, and their effects on the feeding performance of sixth instar S. frugiperda larvae at 48 h post-treatment at three concentrations (1 × 106, 1 × 107, and 1 × 108 conidia mL−1) were also assessed. The six instar S. frugiperda larvae were not susceptible to the five tested fungal isolates. However, B. bassiana ZK-5 caused the highest egg mortality of 40, 70, and 85.6% at 1 × 106, 1 × 107, and 1 × 108 conidia mL−1, respectively, followed by P. citrinum CTD-24 (30.6, 50, and 75.6%) and C. tenuissimum SE-10 (25.6, 40, and 55.6%). In addition, B. bassiana ZK-5 caused the highest neonate mortality of 54.3% at 1 × 108 conidia mL−1. B. bassiana ZK-5 and P. citrinum CTD-24 caused cumulative mortality, including 93.3 and 83.3% mortality of eggs and neonates, respectively, at 1 × 108 conidia mL−1. Furthermore, B. bassiana ZK-5 reduced the feeding efficacy of first to third instar S. frugiperda larvae by 66.7 to 78.6%, while P. citrinum CTD-24 and C. tenuissimum SE-10 reduced larval feeding by 48.3 to 57.1% at 1 × 108 conidia mL−1. However, these fungal isolates were less potent in reducing the feeding activity of fourth to sixth instar S. frugiperda larvae (>46% with B. bassiana at 48 h post-treatment). The tested fungal isolates could play an essential role as microbial biopesticides in suppressing the S. frugiperda population in China after further investigations on their efficacy are obtained in the field.
Correlation Analysis between Hemoglobin and C-Reactive Protein in Patients Admitted to an Emergency Unit
Authors: Santos-Silva Miguel A. , Sousa Nuno , Sousa João Carlos
Published: November 2021

Anemia and inflammation are common clinical conditions in emergency departments. This study explored a cohort of patients admitted to the emergency department with a particular interest in determining the frequency of anemia and inflammation and the association between hemoglobin (Hb) and C-reactive protein (CRP) concentrations. The study included 125 patients categorized according to their demographic (gender and age) and clinical condition (Hb and CRP concentrations, pathological background, and diagnostic). We found that anemia and inflammation were simultaneously present in 36.0% of the cohort, reaching 67.0% in patients that were subsequently hospitalized. The Hb level was significantly lower in patients with elevated concentration of CRP when compared to individuals with normal CRP levels (11.58 ± 2.23 vs. 13.25 ± 1.80, p = 0.001); furthermore, we found a significantly negative correlation between Hb concentration and the CRP level (rs = −0.42, p < 0.001). The linear regression model applied to the cohort showed that CRP levels explain 15% of Hb variations. The sensitivity of the CRP/Hb ratio (cut-off = 1.32) as a predictor of hospitalization was 80.0%, with a specificity of 68.4% for all patients. These findings confirmed the prevalence of anemia and inflammation and identified a moderate but significant association between Hb and serum CRP in a heterogeneous group of patients admitted to the emergency department.
Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
Authors: De Cristofaro Elena , Salvatori Silvia , Marafini Irene , Zorzi Francesca , Alfieri Norma , Musumeci Martina , Biancone Livia , Calabrese Emma , Monteleone Giovanni
Published: November 2021

Background and Aims: Treatment with intravenous corticosteroids (IVCS) is a mainstay in the management of acute severe ulcerative colitis (UC). Although most patients respond to IVCS, little is known about the long-term outcomes. In this study, we assessed the long-term outcomes of IVCS in a real-life cohort. Methods: Disease activity, clinical relapse (partial Mayo score >4), the need for steroids or other maintenance therapies and the rates of colectomy and re-hospitalization were evaluated in consecutive patients admitted to the Tor Vergata University hospital between 2010 and 2020 for acute severe UC who responded to IVCS. Results: Eighty-eight patients were followed up with for a median period of 46 (range 6–133) months. Of these, 56 (64%) patients were treated with 5-aminosalycilic acid and 32 (36%) with immunomodulators or biologics after discharge. A total of 60 out of 88 patients (68%) relapsed, 28 (32%) were re-hospitalized, and 15 (17%) underwent a colectomy with no difference between the two maintenance therapy groups. The multivariate analysis showed that patients in clinical remission 6 months after discharge had a lower risk of relapse during the follow-up. Conclusions: Nearly two-thirds of patients with acute UC responding to IVCS experienced relapse after a median follow-up of 4 years, and this was not influenced by the maintenance therapy.
Practice Guidelines of the Central European Hepatologic Collaboration (CEHC) on the Use of Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease Undergoing Invasive Procedures
Authors: Flisiak Robert , Antonov Krasimir , Drastich Pavel , Jarcuska Peter , Maevskaya Marina , Makara Mihály , Puljiz Željko , Štabuc Borut , Trifan Anca
Published: November 2021

Background: Second-generation thrombopoietin receptor agonists (TPO-RAs) are emerging as the new standard for managing thrombocytopenia (TCP) in patients with chronic liver diseases (CLDs) undergoing scheduled procedures. However, practical guidance for their routine use in CLD patients undergoing specific invasive procedures is lacking. Methods: These practice guidelines were developed by the Initiative Group for Central European Hepatologic Collaboration (CEHC), composed of nine hepatologist/gastroenterologist experts from Central Europe. Using an adapted Delphi process, the CEHC group selected ten invasive procedures most relevant to the hepatology/gastroenterology setting in the region. Consensus recommendations for each invasive procedure are reported as a final percentage of expert panel responses. Results: A consensus was agreed that TPO-RAs should be considered for raising platelet count in CLD patients undergoing scheduled abdominal surgery, high-bleeding risk dentistry, endoscopic polypectomy, endoscopic variceal ligation, liver biopsy, liver surgery, liver transplantation and percutaneous ablation, but it was also agreed that they are less beneficial or not necessary for endoscopy without intervention and paracentesis. Conclusions: Using a modified Delphi method, experts reached an agreement for TCP management in CLD patients undergoing ten invasive procedures. These practice guidelines may help with decision making and patient management in areas where clinical evidence is absent or limited.
Efficacy and Safety of Oral Ibandronate versus Intravenous Zoledronic Acid on Bone Metabolism and Bone Mineral Density in Postmenopausal Japanese Women with Osteoporosis
Authors: Uehara Masashi , Nakamura Yukio , Suzuki Takako , Nakano Masaki , Takahashi Jun
Published: November 2021

There are no published clinical reports comparing ibandronate (IBN) treatment and zoledronic acid (ZOL) treatment in Japanese postmenopausal osteoporotic patients. This investigation therefore compared the efficacy and safety of the drugs on improving bone metabolism and bone mineral density (BMD) in Japanese postmenopausal women with primary osteoporosis. Eighty-two treatment-naïve primary osteoporotic female patients were randomly divided into IBN-treated or ZOL-treated groups. Bone turnover markers and BMD were examined immediately prior to treatment (baseline) and at 6, 12, 18, 24, and 30 months of therapy. Compared with baseline levels, the values of type 1 procollagen N-terminal propeptide, bone-specific alkaline phosphatase (BAP), urinary type-I collagen amino-terminal telopeptide (NTX), and tartrate-resistant acid phosphatase 5b were all significantly decreased at every time point in both groups apart from BAP at 30 months in the ZOL group, urinary NTX at 12 months in the ZOL group and at 24 and 30 months in both groups. Lumbar BMD values were significantly increased at 6, 12, 18, and 24 months in the IBN group and at 6 and 12 months in the ZOL group compared with pre-treatment levels. Hip BMD values were also significantly increased at 6, 12, 18, and 24 months in the IBN group and at 6, 12, and 18 months in the ZOL group compared with baseline values. The percentage changes of hip BMD at 18 and 24 months in the ZOL group were significantly higher than those in the IBN group (both p < 0.05). No remarkable adverse events were noted in either group. In conclusion, both IBN and ZOL significantly and safely improved bone turnover markers and BMD during 30 months of treatment in Japanese osteoporosis patients. The ZOL group tended to exhibit greater gains in BMD as compared with the IBN group, which merits further investigation.
Association between Oral Health Status and Relative Handgrip Strength in 11,337 Korean
Authors: Kim Ji-Eun , Kim Na-Yeong , Choi Choong-Ho , Chung Ki-Ho
Published: November 2021

Grip strength is a simple indicator of physical strength and is closely associated with systemic health. Conversely, oral health has also been reported to have an important association with systemic health. The present study aimed to assess the effect of oral health status on relative handgrip strength. The data pertaining to 11,337 participants were obtained by means of the seventh Korea National Health and Nutrition Survey (2016 to 2018). Oral health status was evaluated on the basis of the presence of periodontitis and number of remaining teeth (PT, present teeth). Relative handgrip strength was evaluated by means of a digital dynamometer and the value pertaining to the lower 25% of measurements was used as the quartile by gender. The association between oral health status and relative handgrip strength was evaluated by means of multiple regression analysis and multiple logistic regression analysis with covariate correction. Analysis of the crude model revealed a significant association in the group of patients with periodontal disease (odds ratio = 1.69, 95% confidence interval: 1.51–1.89). However, analysis with adjusted covariates revealed that the association was not statistically significant. Moreover, statistical analysis after adjustment for covariates revealed a consistent correlation between PT and relative handgrip strength as categorical and continuous variables. Hence, the present study observed a significant association between oral health status and relative handgrip strength among the Korean adult population.
Retinal Changes before and after Silicone Oil Removal in Eyes with Rhegmatogenous Retinal Detachment Using Swept-Source Optical Coherence Tomography
Authors: Lee Jungwook , Cho Heeyoon , Kang Minho , Hong Rimkyung , Seong Mincheol , Shin Yongun
Published: November 2021

This study aimed to evaluate and compare the retinal and choroidal thickness and vessel density (VD) changes between silicone oil (SO) tamponade and after SO removal using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). Thirty patients who underwent pars plana vitrectomy for retinal detachment (RD) with SO tamponade were included. SS-OCT and OCTA were conducted before RD surgery, during SO tamponade, and after SO removal. A 3-dimensional volumetric wide scan protocol was used for the analysis. The segmented retina, choroidal thickness map, and peripapillary thickness were then measured. For the OCTA analysis, 4.5 × 4.5 mm scans were used. Superficial and deep capillary plexus VDs in unaffected fellow eyes and eyes after SO removal were compared. During the SO tamponade period, the thickness of the parafoveal total retina, ganglion cell-inner plexiform layer, and peripapillary retinal nerve fiber layer (ppRNFL) were significantly thinner than those of unaffected fellow eyes (p < 0.05). The parafoveal layer thickness thinning recovered up to three to six months after SO removal. Moreover, six months after SO removal, the parafoveal thickness was not significantly different compared to that of unaffected fellow eyes (p > 0.05). However, the ppRNFL thickness was significantly decreased during SO tamponade and remained unrecovered six months after SO removal. There was no significant difference in the VD on the OCTA. Thus, SO tamponade and removal for RD resulted in a change in the retinal and peripapillary thickness. This may be due to the mechanical pressure effect of SO.
Surf Zone Turbulence and Suspended Sediment Dynamics—A Review
Authors: Aagaard Troels , Brinkkemper Joost , Christensen Drude F. , Hughes Michael G. , Ruessink Gerben
Published: November 2021

The existence of sandy beaches relies on the onshore transport of sand by waves during post-storm conditions. Most operational sediment transport models employ wave-averaged terms, and/or the instantaneous cross-shore velocity signal, but the models often fail in predictions of the onshore-directed transport rates. An important reason is that they rarely consider the phase relationships between wave orbital velocity and the suspended sediment concentration. This relationship depends on the intra-wave structure of the bed shear stress and hence on the timing and magnitude of turbulence production in the water column. This paper provides an up-to-date review of recent experimental advances on intra-wave turbulence characteristics, sediment mobilization, and suspended sediment transport in laboratory and natural surf zones. Experimental results generally show that peaks in the suspended sediment concentration are shifted forward on the wave phase with increasing turbulence levels and instantaneous near-bed sediment concentration scales with instantaneous turbulent kinetic energy. The magnitude and intra-wave phase of turbulence production and sediment concentration are shown to depend on wave (breaker) type, seabed configuration, and relative wave height, which opens up the possibility of more robust predictions of transport rates for different wave and beach conditions.
Surface Chlorophyll-A Fronts in the Yellow and Bohai Seas Based on Satellite Data
Authors: Xia Lu , Liu Hao , Lin Lei , Wang Yueqi
Published: November 2021

Chlorophyll fronts are important to monitor and map the oceanic front, especially in the season when sea surface temperature (SST) fronts weaken. In this study, surface chlorophyll-a (chl-a) fronts in the Yellow and Bohai seas were characterized for the first time using satellite data. Five distinct chl-a fronts (i.e., the Bohai Strait, Shandong Peninsula, Jiangsu, Liaodong Peninsula, and Korean Peninsula fronts) were observed in summer along the 40 m isobaths and faded in other seasons. Notably, these fronts coincided with SST fronts. Strong chl-a fronts emerged during summer due to chl-a blooms in eutrophic coastal waters paired with surface chl-a fading in strongly stratified offshore waters and coastal physical fronts. Although SST fronts were strong during winter, light limitation and strong vertical mixing in offshore waters led to low chl-a in both coastal and offshore waters, suppressing chl-a front formation. Both chl-a and SST fronts coincided with steep seabed slopes (slope ratio > 1), suggesting that seabed slope may be an indicator of oceanic front location.
Robust Parameter Estimation of an Empirical Manoeuvring Model Using Free-Running Model Tests
Authors: Costa Ana Catarina , Xu Haitong , Guedes Soares Carlos
Published: November 2021

The work presents the identification and validation of the hydrodynamic coefficients for the surge, sway, and yaw motion. This is performed in two ways: using simulated data and free-running test data. The identification and validation with the simulation data are carried out using a 25° turning test and a 20°−20° zigzag manoeuvring test. For the free-running test data, two zigzag manoeuvres are used: 30°−30° zigzag for identification and 20°−20° zigzag for validation. A nonlinear manoeuvring model is proposed based on the standard Euler equations, and the hydrodynamic coefficients are computed using empirical equations. To obtain robust results, the truncated singular value decomposition is employed to diminish the multicollinearity and the parameter uncertainties due to noise. The validation is carried out by comparing the result of the measured values with the predictions obtained using the manoeuvring models. Finally, a sensitivity analysis for the simulation data is performed to understand the influence of the parameters in the manoeuvres.
Effect of Database Generation on Damage Consequences’ Assessment Based on Random Forests
Authors: Braidotti Luca , Prpić-Oršić Jasna , Valčić Marko
Published: November 2021

Recently, the application of machine learning has been explored to assess the main damage consequences without employing flooding sensors. This method can be the base of a new generation of onboard decision support systems to help the master during the progressive flooding of the ship. In particular, the application of random forests has been found suitable to assess the final fate of the ship and the damaged compartments’ set and estimate the time-to-flood. Random forests have to be trained using a database of precalculated progressive flooding simulations. In the present work, multiple options for database generation were tested and compared: three based on Monte Carlo (MC) sampling based on different probability distributions of the damage parameters and a parametric one. The methods were tested on a barge geometry to highlight the main effects on the damage consequences’ assessment in order to ease the further development of flooding-sensor-agnostic decision support systems for flooding emergencies.
Station-Keeping Control of Autonomous and Remotely-Operated Vehicles for Free Floating Manipulation
Authors: Ding Ningning , Tang Yuangui , Jiang Zhibin , Bai Yunfei , Liang Shixun
Published: November 2021

This paper investigates the station-keeping control of autonomous and remotely-operated vehicles (ARVs) for free-floating manipulation under model uncertainties and external disturbances. A modified adaptive generalized super-twisting algorithm (AGSTA) enhanced by adaptive tracking differentiator (ATD) and reduced-order extended state observer (RESO) is proposed. The ATD is used to obtain the smooth reference signal and its derivative. The RESO is used to estimate and compensate for the model uncertainties and external disturbances in real-time, which enhances the robustness of the controller. The modified AGSTA ensures the fast convergence of the system states and maintains them in a predefined neighborhood of origin without overestimating control gains. Besides, the proposed new variable gain strategy completely avoids the control gains vibrating near the set minimum value. Thanks to the RESO, the proposed controller is model-free and can be easily implemented in practice. The stability of the closed-loop system is analyzed based on Lyapunov’s direct method in the time domain. Finally, the proposed control scheme is applied to the station-keeping control of Haidou-1 ARV, and the simulation results confirm the superiority of the proposed control scheme over the original AGSTA.
The Protective Effect of Digital Financial Inclusion on Agricultural Supply Chain during the COVID-19 Pandemic: Evidence from China
Authors: Fang Da , Zhang Xiaoke
Published: November 2021

Financial inclusion plays a positive role in protecting agriculture during or after disaster. This paper focuses on the protective effect of digital financial inclusion on the agricultural supply chain and analyzes three mechanisms of the protective effect: financial widening, financial deepening, and financial services digitization. Based on the Gravity Equation, we conduct an empirical study using agricultural logistics and digital financial inclusion data from China. The regression results indicate that a 1% increase in the digital financial inclusion, measured by the Peking University Digital Inclusion Index, increases agricultural trade during the COVID-19 pandemic by approximately 1.6%. Furthermore, heterogeneous protective effects exist between regions in China. Digital financial inclusion is more effective in the Eastern regions in protecting the ASC than in other regions. This paper enriches the understanding of financial inclusion in helping agriculture supply chain recovery.
Morphodynamics of Gully Development on the Platform–Slope System of Spoil Dumps under Platform Concentrated Flow
Authors: Bai Yun , Guo Mingming , Kang Hongliang , Wang Wenlong , Su Huan , Guo Wenzhao , Ma Chunyan
Published: November 2021

Severe gully erosion on spoil dumps, caused by dense concentrated flow derived from platforms, poses a significant threat to the land management of mining areas. However, little is known about the development processes and mechanisms of gullies on spoil dumps. A flow scouring experiment was conducted on an established platform–slope system under 3.6–5.04 m3 h−1. The soils of the system consisted of a surface sandy loam A layer and anunderlying clay loam B layer. The results showed that the platform exhibited a gully development process of headcut-incision–headcut-expansion–stabilization and the steep slope experienced gully development of A-layer incision–A-layer expansion–B-layer incision–stabilization. The results showed 88.97–100% of Froude Number (Fr) decrement and 47.90–88.97% of Darcy–Weisbach roughness coefficient increment finished in the two incision stages on the steep slope. Gully depth has the most sensitive response to flow hydraulics. A significant linear correlation exists between gully depth and shear stress, runoff power, Fr, and Reynolds Number (R2 > 0.337). Overall, the optimal hydraulic indicator varies within different stages for describing the gully morphology development, illustrating the different action mechanism between flow hydraulics and gully morphology. Our findings provide a theoretical support for future mechanistic studies of gully erosion and the land management on spoil dump.
A Continental-Scale Connectivity Analysis to Predict Current and Future Colonization Trends of Biofuel Plant’s Pests for Sub-Saharan African Countries
Authors: Iannella Mattia , De Simone Walter , Cerasoli Francesco , D’Alessandro Paola , Biondi Maurizio
Published: November 2021

Biofuel production in Sub-Saharan Africa is an important part of local low-income countries. Among many plant species, Jatropha curcas gained popularity in this area, as it can be grown even where crops of agricultural interest cannot. A natural African pest of J. curcas is the Aphthona cookei species group, for which future climatic suitability is predicted to favor areas of co-occurrence. In this research, we identify the possible climatic corridors in which the colonization of J. curcas crops may occur through a circuit theory-based landscape connectivity software at a country scale. Additionally, we use the standardized connectivity change index to predict possible variations in future scenarios. Starting from ecological niche models calibrated on current and 2050 conditions (two different RCP scenarios), we found several countries currently showing high connectivity. Ghana, Zambia and Ivory Coast host both high connectivity and a high number of J. curcas cultivations, which is also predicted to increase in the future. On the other side, Burundi and Rwanda reported a future increase of connectivity, possibly acting as “connectivity bridges” among neighboring countries. Considering the economic relevance of the topic analyzed, our spatially explicit predictions can support stakeholders and policymakers at a country scale in informed territorial management.
Diagonal Tensile Test on Masonry Panels Strengthened with Textile-Reinforced Mortar
Authors: Ungureanu Dragoș , Țăranu Nicolae , Ghiga Dan Alexandru , Isopescu Dorina Nicolina , Mihai Petru , Cozmanciuc Ruxandra
Published: November 2021

This study presents the results of an experimental and numerical program carried out on unreinforced masonry panels strengthened by textile-reinforced mortar (TRM) plastering. For this purpose, five panels were constructed, instrumented and tested in diagonal shear mode. Two panels were tested as reference. The first reference panel was left unstrengthened, while the second one was strengthened by a traditional self-supporting cement mortar matrix reinforced with steel meshes. The remaining three panels were strengthened by TRM plastering applied on one or both faces and connected with transversal composite anchors. The numerical and the experimental results evidenced a good effectiveness of the TRM systems, especially when applied on both panel facings.
Pop-In Identification in Nanoindentation Curves with Deep Learning Algorithms
Authors: Kossman Stephania , Bigerelle Maxence
Published: November 2021

High–speed nanoindentation rapidly generates large datasets, opening the door for advanced data analysis methods such as the resources available in artificial intelligence. The present study addresses the problem of differentiating load–displacement curves presenting pop-in, slope changes, or instabilities from curves exhibiting a typical loading path in large nanoindentation datasets. Classification of the curves was achieved with a deep learning model, specifically, a convolutional neural network (CNN) model implemented in Python using TensorFlow and Keras libraries. Load–displacement curves (with pop-in and without pop-in) from various materials were input to train and validate the model. The curves were converted into square matrices (50 × 50) and then used as inputs for the CNN model. The model successfully differentiated between pop-in and non-pop-in curves with approximately 93% accuracy in the training and validation datasets, indicating that the risk of overfitting the model was negligible. These results confirmed that artificial intelligence and computer vision models represent a powerful tool for analyzing nanoindentation data.
Creating a Material Spectral Library for Plaster and Mortar Material Determination
Authors: Matoušková Eva , Pavelka Karel , Ibrahim Saleem
Published: November 2021

Historic object analysis and the knowledge of composition play an important role in restoration processes. Based on this information, restoration works are conducted. This paper introduces a non-invasive technique of plaster and mortar material decomposition using reflectance spectroscopy. For this purpose, a NIRQuest512-2,5 from Ocean Optics®/Ocean Insight®, is used to create a unique spectral library consisting of various materials. They were carefully selected to include those that were and still are commonly used for a plaster and mortar production. Each material of the spectral library was mapped in detail, verified using scanning electronic microscope (SEM) data, and the results were compared to a previously determined spectral signature. The new spectral library was then tested on 11 unknown plaster and mortar samples and verified using a scanning electronic microscope. It was found that reflectance spectroscopy provides a powerful tool for plaster and mortar material decomposition, although at the moment it cannot fully replace invasive techniques like chemical analyses or other invasive techniques. It provides relevant information that can be used for restoration works.