bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics, treatment, and outcomes of cutaneous mantle cell lymphoma: A decade-long study at MD Anderson Cancer Center.
Authors: Gaulin Charles , Zhang Jared R. , Wu Susan Y. , Jain Preetesh , Ok Chi , Yan Fangfang , Chen Wendy , Oriabure Onyeka , Dabaja Bouthaina Shbib , Gunther Jillian Rebecca , Fang Penny , Pinnix Chelsea Camille , Wang Michael
Published: July 2024

e19037

Background: Mantle cell lymphoma (MCL) is a rare B cell neoplasm that accounts for 6% of all non-Hodgkin lymphomas and affects predominantly older Caucasian males. Cutaneous involvement is rare in MCL, but more commonly occurs in the advanced or terminal stages of the disease and lacks a standardized approach. Here we report our center’s experience with cutaneous MCL. Methods: We conducted a retrospective chart review of all MCL patients treated at the University of Texas MD Anderson Cancer Center from January 2013 to December 2023 and identified 20 MCL patients with cutaneous involvement. Demographic data, disease characteristics, imaging findings, therapies, and survival outcomes were collected. The study was performed in accordance with the guidelines of the institutional review board. Results: Among the 20 MCL patients with cutaneous involvement (Table), nearly all were Caucasian (n=19/20, 95%), and most were male (n=14/20, 70%). The median age at cutaneous MCL diagnosis was 63.5 years (range: 50-83). All patients had advanced stage disease. The median interval from MCL diagnosis to the emergence of cutaneous symptoms was 2.2 years (range 0-9.3). Most had relapsed/refractory disease (n=17/20, 85%). Most patients had blastoid (n=13/19) or pleomorphic (n=4/19) cytology with a Ki-67 proliferative index ≥50% (n=19/20, median 90%). Several patients had p53 expression (n=11/14) and/or TP53 aberrations (n=4/16). Immediate subsequent systemic therapy, most commonly immunochemotherapy (n=9/20), led to frequent responses (overall response rate: 61%). Most patients received low-dose radiotherapy (RT) for their cutaneous disease (n=19/20) achieving high rates of local control (n=16/18). Of those who are alive and in complete response (n=3) at data cutoff, 2 received chimeric antigen receptor (CAR) T cell therapy as their last MCL-directed treatment. The median survival time from MCL diagnosis to death was 6.83 years (95% confidence interval (CI):4.20-not estimable (NE)). The median survival time from the diagnosis of cutaneous involvement to death was 3.16 years (95%CI: 1.93-NE). The median follow-up duration from MCL diagnosis was 8.22 years. Conclusions: Cutaneous involvement in MCL is associated with aggressive disease biology and poor survival outcomes. Low-dose RT with concurrent immunochemotherapy should be considered the current standard therapeutic approach. CAR T cell therapy and/or bispecific T cell engagers may further improve outcomes in these high-risk patients. [Table: see text]
Real-world evaluation of treatment pattern, time to next treatment (TTNT), healthcare resource utilization (HCRU), and cost of care in follicular lymphoma (FL).
Authors: Gaballa Sameh R , Xue Mei , Chuang Po-Ya , Esselman Kaitlyn , Furnback Wesley , Yang Keri
Published: July 2024

e19044

Background: FL often becomes relapsed or refractory (R/R) to treatment. This study aimed to analyze TTNT, HCRU, and cost of care in FL. Methods: A retrospective study was conducted using Optum Clinformatics Data Mart to identify patients ≥18 years with ≥1 diagnosis for FL initiating 1L, 2L, 3L, or 4L treatment from 1/2019 to 02/2023. Patients were required to be continuously enrolled for 30 days pre- and post-index date, defined as the date of treatment initiation. Patients were categorized into mutually exclusive cohorts based on treatment regimen. TTNT was measured for patients who had a subsequent treatment within the study period. Total cost of care included both plan- and patient-paid claims, adjusted for inflation (2023 USD). HCRU included outpatient visits and inpatient admissions. Costs and HCRU were reported per patient per month over the treatment duration. Results: There were 4,525 patients initiating 1L treatment and 1,053, 304, and 97 patients initiating 2L, 3L, and 4L treatment, respectively. Median follow-up was 487 days (1L), 430 days (2L), 357 days (3L), and 276 days (4L). The mean age at the index was similar across cohorts (range: 69.6 [1L] to 71.9 [4L]). Rituximab monotherapy (R-mono) was the most utilized treatment in 1L and 2L, followed by bendamustine + rituximab (BR) and R-CHOP (Table). Lenalidomide + rituximab (R2) was the most utilized regimen in 3L and 4L. Obinutuzumab monotherapy (O-mono) use increased by line of therapy. The median TTNT across all regimens decreased by line of therapy (Table). BR and bendamustine + obinutuzumab (BO) had longer TTNT in 1L, while BR and R2 had longer TTNT in 3L. Inpatient admissions and outpatient visits increased with the line of therapy. Mean (SD) outpatient visits were 5.3 (3.2) in 1L, 5.8 (3.7) in 2L, 6.3 (4.0) in 3L, and 6.1 (3.3) in 4L, while inpatient admissions ranged from 0.1 (0.3) in 1L to 0.3 (0.4) in 4L. The mean total cost of care ranged from $40,538-$74,466, increasing by line of therapy. The mean total cost of care was consistently lowest in R-mono ($31,704-$36,197), while CAR-T had the highest total cost ($501,493-$522,378). R-mono had the lowest while R-CHOP had the highest mean outpatient visits across lines of therapy. Conclusions: Real-world TTNT decreased while costs and HCRU increased with each subsequent line of treatment, indicating a high disease burden in FL patients, particularly for those with R/R FL.These findings suggest the need for better treatment options for patients with FL, especially in 3L and 4L. [Table: see text]
Comparison of zanubrutinib (zanu) and acalabrutinib (acala) in B-cell malignancies: An adverse event (AE)-based analysis.
Authors: Munir Tahla , Wang Yucai , Mohseninejad Leyla , Srivastava Tushar , Gupta Anurag , Gautam Raju , Challagulla Swetha , Xue Mei , Yang Keri , Williams Rhys , Levy Vincent , Zhou Shouhao
Published: July 2024

e19049

Background: Acala and zanu are 2nd generation Bruton tyrosine kinase inhibitors (BTKis) that have demonstrated improved safety profiles vs 1st generation BTKi ibrutinib in clinical trials. While head-to-head comparison of zanu vs acala is lacking, a recent meta-analysis of clinical trials provided a comprehensive, indirect comparison of the AE profiles in B-cell malignancies (Hwang, Hemasphere. 2023;7(S3):1134). This study aims to evaluate costs and impacts on quality of life (QoL) for zanu vs acala using their AE profiles. Methods: A health economic model was developed to determine cost and QoL associated with AE management for zanu and acala. The incidence rates ( IRs) of all grade and grade ≥3 AEs of interest (n=21, including bleeding events, hypertension, atrial fibrillation, cytopenias, infections, headache, arthralgia, diarrhea) were taken from the meta-analysis. Additional model inputs, such as disutility, average duration of AE, and unit cost of each AE were sourced from published literature and publicly available cost databases in consultation with clinical experts. The model was developed from the US perspective, considering Medicare costs, inflated to 2023 USD. Model outcomes were AE management cost (= IR * unit cost) and quality-adjusted life years (QALYs) lost due to AE (= IR * Disutility * Duration/365.25). Results: In the base-case scenario (considering all AEs), treating a hypothetical cohort of 1000 patients (pts) with zanu instead of acala yielded cost savings of $124K and 3.7 QALY gains (i.e., 3.7 years extra in full health). Subgroup analysis for severe (grade ≥3) and non-severe AEs (grade 1-2) demonstrated similar trends. A sensitivity analysis limited to AEs significantly different between zanu and acala (n=13) yielded consistent results. Additionally, a probabilistic sensitivity analysis, conducted with 1000 iterations to account for uncertainty in model parameters, confirmed robustness of the model, indicating stable conclusions across a wide range of parameter uncertainties. Conclusions: This analysis suggested that zanu is cost-saving and associated with added health benefits compared to acala in terms of AE management in pts with B-cell malignancies. Should these results derived from meta-analysis of clinical trial data be applicable to real-world pt populations across different indications, the potential cost savings could be considerable. These results could be further improved if the differences in efficacy of zanu vs acala are also incorporated. [Table: see text]
A phase 1/2 study of BDC-3042, a novel dectin-2 agonistic antibody, in patients with advanced cancers.
Authors: Salkeni Mohamad Adham , Vandross Andrae L. , Dumbrava Ecaterina Elena , Giordano Antonio , Chen Christopher , Kenkel Justin , Cai Danlin , Xu Lu , Alonso Michael N. , Ackerman Shelley , Yu Tai , Colburn Dawn E. , Perez Edith A. , Wilks Sharon
Published: July 2024

TPS2695

Background: Tumor-associated macrophages (TAMs) are a major component of the immune infiltrate in most cancers and play a key role in establishing the immunosuppressive tumor microenvironment (TME) that enables tumor progression. However, TAMs are phenotypically plastic and have the potential to be reprogrammed into immunostimulatory cells that enhance innate and adaptive anti-tumor immunity. BDC-3042 is a novel agonistic antibody targeting an immune-activating receptor expressed on TAMs known as Dectin-2 ( CLEC6A) [1]. Dectin-2 is a C-type lectin receptor best known for its role in pathogen recognition and induction of protective immune responses against fungi and other microbes. We have previously demonstrated that Dectin-2 agonism stimulates pro-inflammatory cytokine secretion and antigen presentation by TAMs, resulting in robust CD8+ T cell-mediated anti-tumor immunity in syngeneic mouse models [2]. Elevated gene expression of Dectin-2 has been found in a wide range of solid tumor types compared to non-malignant tissues. Nonclinical studies with BDC-3042 have demonstrated its potential to reprogram TAMs and elicit anti-tumor activity as a novel immunotherapeutic approach for diverse human cancers [2]. A phase 1/2, first-in-human, dose-escalation and dose-expansion study of BDC-3042 as a single agent and in combination with a cemiplimab in subjects with advanced cancers has been initiated. Methods: This study is enrolling up to 185 patients with advanced cancers, including non-small cell lung cancer, melanoma, triple-negative breast cancer, renal cell carcinoma, colon cancer, head and neck cancer, and ovarian cancer. Primary objectives of the dose-escalation phase are to define safety and tolerability and to determine the recommended phase 2 dose (RP2D) of BDC-3042 as a monotherapy (Part 1) and in combination with cemiplimab (Part 2). The dose-expansion phase will evaluate preliminary anti-tumor activity of BDC-3042 monotherapy (Part 3) and with cemiplimab (Part 4). Secondary objectives will evaluate pharmacokinetic parameters and pharmacodynamic biomarkers in tumor tissue and in peripheral blood associated with drug exposure. Exploratory analyses will also be conducted to assess BDC-3042’s ability to reprogram TAMs and identify biomarkers associated with BDC-3042 biological activity and with cemiplimab. This study is being conducted in the US and is currently recruiting patients. 1. Kenkel J, et al. Cancer Res. 2023. 2. Kenkel J, et al. J Immunother Cancer. 2021. Clinical trial information: NCT06052852 .
A phase 1/1b, first-in-human, multi-part study of DF6215, an engineered IL-2Rα-active agonist, to investigate the safety, tolerability, pharmacokinetics, and biological and clinical activity in patients with advanced solid tumors.
Authors: Carneiro Benedito A. , McKean Meredith , Vicier Cecile , Valerin Jennifer Brooke , Tarhini Ahmad A. , Ganju Vinod , Ruisi Mary M. , Kirby Patrick , Cuillerot Jean-Marie , Romano Emanuela
Published: July 2024

TPS2704

Background: IL-2 is a pleiotropic cytokine that stimulates strong anti-tumor responses by promoting expansion and activation of cytotoxic tumor-infiltrating immune cells including CD8 + T cells and NK cells (1). Aldesleukin is an approved rhIL-2; however, it has clinical limitations due to short half-life, requirement for 5 days of hospitalization per cycle, and high toxicity [eg, cytokine-related toxicity, capillary leak syndrome (CLS)] that limits its use [aldesleukin USPI]. DF6215 is a modified monovalent human IL-2 that binds to the IL2R. Preclinically, DF6215 administration results in sustained and modulated IL-2 pharmacology, leading to protracted pharmacodynamic (PD) effects and enhanced anti-tumor activity without observation of CLS in murine and primate toxicology studies. In response to the limitations of previous IL-2 therapeutics, DF6215 was designed as an IL-2Rα-active agonist with increased IL-2Rβγ stimulation to improve the benefit-to-risk ratio of historic IL-2 drugs. An additional design element is a prolonged elimination half-life due to Fc fusion, allowing for less frequent dosing. Methods: This is a first-in-human, open-label, multipart, Phase 1/1b clinical trial to characterize the initial safety, tolerability, pharmacokinetics, and preliminary efficacy of DF6215 in patients with advanced solid tumors. The Phase 1 dose escalation (DE) starting dose is 10 ug/kg IV every 2 weeks (up to 42 subjects expected to be enrolled), and the Safety/PK/PD will be explored at doses already characterized as safe in dose escalation and potentially efficacious (max of 40 subjects). Phase 1b includes an efficacy expansion (EE) cohort in subjects with advanced melanoma who have received prior anti-PD-1 agents and, if the tumor harbors a BRAF-activating mutation, a BRAF inhibitor. Key inclusion criteria include ≥ 18 years of age; ECOG PS of 0 or 1; adequate organ function, and locally advanced or metastatic solid tumors for which standard therapy options have been exhausted; and availability of baseline tumor biopsy. Primary objectives include determination of the MTD of DF6215 in DE and demonstration of clinical activity of DF6215 in the EE. Secondary objectives include assessment of safety and tolerability, pharmacokinetics, and immunogenicity of DF6215. This study plans to enroll up to 102 subjects across ~30 global centers in the US, European, and the Asia/Pacific regions, and is currently open to enrollment. 1. Arenas-Ramirez N, et al. 2015. Trends Immunol. Clinical trial information: NCT06108479 .
Open-Label, Multicenter, Phase I/II, First-in-Human Trial of TK216: A First-Generation EWS::FLI1 Fusion Protein Antagonist in Ewing Sarcoma
Authors: Meyers Paul A. , Federman Noah , Daw Najat , Anderson Peter. M. , Davis Lara E. , Kim AeRang , Macy Margaret E. , Pietrofeso Angela , Ratan Ravin , Riedel Richard F. , Trucco Matteo , Breitmeyer James B. , Toretsky Jeffrey A. , Ludwig Joseph A.
Published: July 2024

PURPOSE

Ewing Sarcoma (ES), a rare cancer with a pathognomonic translocation resulting in the Ewing sarcoma gene (EWS)::FLI1 oncoprotein, has a poor prognosis in the relapsed/refractory (R/R) setting. Tokalas (TK)216 was designed to bind EWS::FLI1 proteins directly, disrupt protein-protein interactions, and inhibit transcription factor function. TK216 plus vincristine showed synergistic activity in preclinical tumor models. To our knowledge, we report the results of a first-in-class, first-in-human phase I/II trial of TK216 in R/R ES.

PATIENTS AND METHODS

TK216 was administered intravenously as a continuous infusion to patients with R/R ES in 11 cohorts. The dosing duration of 7 days was later extended to 10, 14, and 28 days. Vincristine could be added on day 1 after cycle 2, per investigators’ choice. The trial used a 3 + 3 design with an expansion cohort at the recommended phase II dose (RP2D).

RESULTS

A total of 85 patients with a median age of 27 years (range, 11-77) were enrolled. The maximum tolerated dose for the 14-day infusion of TK216, 200 mg/m
2
once daily, was determined in cohort 9 and selected as the RP2D. The median previous number of systemic therapies regimens was three (range, 1-10). The most frequent-related adverse events in patients treated at the RP2D included neutropenia (44.7%), anemia (29.4%), leukopenia (29.4%), febrile neutropenia (15.3%), thrombocytopenia (11.8%), and infections (17.6%). In cohorts 9 and 10, two patients had a complete response, one had a partial response, and 14 had stable disease; the 6-month progression-free survival was 11.9%. There were no responses among the eight patients in cohort 11.

CONCLUSION

TK216 administered as 14-day continuous infusion with or without vincristine was well tolerated and showed limited activity at the RP2D in R/R ES.
Dynamics of diseases spreading on networks in the forms of reaction-diffusion systems
Authors: Sun Gui-Quan , He Runzi , Hou Li-Feng , Gao Shupeng , Luo Xiaofeng , Liu Quanhui , Zhang Yicheng , Chang Lili
Published: July 2024

In the face of persistent threats posed by infectious diseases, despite remarkable medical advancements, understanding and efficiently controlling their spatial spread through mathematical modeling remain imperative. Networked reaction-diffusion systems offer a promising avenue to effectively delineate population discrete distribution and individual movement heterogeneity. However, the dynamics of spatial diseases within these systems and the formulation of optimal control strategies are currently undergoing vigorous development. In this letter, we illustrate the dynamics of spatial disease spread in networked reaction-diffusion systems through the lens of optimal control, considering various network complexities from pairwise networks to higher-order networks. It then emphasizes their applicability in designing effective spatial disease control strategies across diverse network complexities. Finally, we discuss the existing challenges.
Martha and the Swans: BTS, “Black Swan,” and Cold War Dance History
Authors: Wong Yutian
Published: July 2024

In “Martha and the Swans: BTS, ‘Black Swan,’ and Cold War Dance History,” Yutian Wong situates stage performances of BTS’s “Black Swan” as the end result of the culture wars that took place in theaters across East and Southeast Asia in the 1950s. With Martha Graham’s abstract expressionism and the Bolshoi’s classicism representing aesthetic extremes on a shared bill, stage performances of “Black Swan” embodies this history. In her close reading of three different stagings of “Black Swan,” Wong argues that taken as a whole, the multiple versions of the stage performance utilize performance conventions, choreographic structures, movement motifs, and costume choices that reference the two most common tropes of Cold War dance history (Graham vs. the Swan) and mirrors back the end result—a reflection on the condition of a K-Pop idol as a product of Cold War culture wars.
Recoding the Bot: ARMY and Digital Transgression
Authors: Acosta Andrea L.
Published: July 2024

Andrea L. Acosta’s contribution, “Recoding the Bot: ARMY and Digital Transgression,” reflects on the equivalencies that are often made between the online “bot” and ARMY, usually to discredit BTS’s popularity as the result of mechanistic, horde behavior. Parsing the deeply racialized figure of the “bot” illuminates the very human investments behind digital strategies of resistance and anti-surveillance that have sparked solidarities with Black Lives Matter and anti-fascist movements. Rather than refuting or rejecting the bot label, she is interested in what the metaphor of the bot—and the idea of a human passing for one—can offer when understood as a deliberate strategy for online organization and behavior. Fans harness bot behavior to manipulate algorithms to their own ends: achieving higher YouTube views or better music chart positions, censoring detractors—even facilitating political protest.
“Spring Day”: Nostalgia, Pop Mediation, and Public Mourning
Authors: Cho Michelle
Published: July 2024

Michelle Cho’s “‘Spring Day’: Nostalgia, Pop Mediation, and Public Mourning” is an analysis of the group’s 2016 single and music video “Spring Day” and fan-produced videos about the music video as an allegory for the 2014 Sewol ferry tragedy, in which a South Korean ferry capsized, killing more than 300 passengers, 250 of whom were high school sophomores on a field trip. In her chapter, Cho analyzes the music video’s intertexts, from literature (LeGuin), cinema (Bong Joon-ho’s Snowpiercer), contemporary art (Christian Boltanski’s “Personnes”), and references to the leitmotif of yellow ribbons—the shared sign of Sewol victims’ memorialization. Cho details how Korean and international fans engage in a form of networked-yet-informal social justice work by contextualizing the local South Korean and global-systemic, geopolitical conditions that caused the disaster, demonstrating the song’s ability to enable collective grief and public mourning across a translocal fandom.
Fifty Shades of Butter: Consensual Nonconsent in BTS Fan Fiction
Authors: Diego Raymond San
Published: July 2024

In “Fifty Shades of Butter: Consensual Nonconsent in BTS Fan Fiction,” Raymond San Diego examines a subgenre of self-insert fan fiction featuring BTS. The phenomena of “Y/N” or “Your name” stories is a largely Anglophone genre of fan-fiction videos distributed on social media platforms like YouTube, Instagram, and TikTok where images and video clips of BTS members are deterritorialized and become erotically charged when juxtaposed with the author’s writing. Through an analysis of the visual and written texts, comments sections between fans and authors (both celebratory and disapproving), and their transnational circulation across social media platforms, San Diego details the ways in which these fan fictions move away from often-reductive conceptions of consent, enabling a demystification of sexual desire altogether.
Open Admissions
Authors: Savonick Danica
Published: July 2024

In Open Admissions Danica Savonick traces the largely untold story of the teaching experience of Toni Cade Bambara, June Jordan, Audre Lorde, and Adrienne Rich at the City University of New York (cuny) in the late 1960s and early 1970s. This period, during which cuny guaranteed tuition-free admission to every city high school graduate, was one of the most controversial in US educational history. Analyzing their archival teaching materials—syllabi, lesson plans, and assignments—alongside their published work, Savonick reveals how these renowned writers were also transformative educators who developed creative methods of teaching their students to navigate and change the world. In fact, many of their methods—such as student-led courses, collaborative public projects, and the publication of student writing—anticipated the kinds of student-centered and antiracist pedagogies that have become popular in recent years. In addition to recovering the pedagogical legacy of these writers, Savonick shows how teaching in cuny’s free and open classrooms fundamentally altered their writing and, with it, the course of American literature and feminist criticism.
Τοπικές ενεργειακές αγορές
Authors: Ανδριόπουλος Κωνσταντίνος-Νικόλαος
Published: July 2024

Η παρούσα διατριβή παρουσιάζει την ανάπτυξη μιας ανθρωποκεντρικής τοπικής αγοράς ενέργειας, η οποία επικεντρώνεται στην ενδυνάμωση των καταναλωτών και των prosumers, δίνοντάς τους τη δυνατότητα να συμμετέχουν ενεργά και αποτελεσματικά στην αγορά ηλεκτρικής ενέργειας. Κύριος στόχος είναι η δημιουργία ενός δικαιότερου, πιο διαφανούς και αποδοτικού συστήματος, που ελαχιστοποιεί το λειτουργικό κόστος και ενθαρρύνει την προσέλκυση και διατήρηση μελών. Μέσω μιας καινοτόμου αρχιτεκτονικής αγοράς με επίκεντρο τον χρήστη, η διατριβή εξερευνά την ανεμπόδιστη συμμετοχή των καταναλωτών και την ένταξη των προτιμήσεων τους στη διαδικασία βελτιστοποίησης, ενισχύοντας την τοπική ευελιξία και εκδημοκρατικοποίηση της αγοράς. Η ανάλυση επεκτείνεται επίσης στις ιεραρχικές αγορές ενέργειας και στο πώς αυτές μπορούν νασυμβάλλουν στην αντιμετώπιση απειλών κυβερνοασφάλειας, ενισχύοντας την ανθεκτικότητα του δικτύου μέσω της χρήσης κομβικών αγορών ενέργειας. Αυτή η προσέγγιση όχι μόνο αυξάνει την αποδοτικότητα του συστήματος αλλά επίσης παρέχει έναν ισχυρό μηχανισμό αντίδρασης σε περίπτωση κυβερνοεπιθέσεων, προάγοντας την ασφάλεια και την ανθεκτικότητα της τοπικής αγοράς ενέργειας. Συνολικά, η διατριβή αναδεικνύει τη σημασία της εισαγωγής και λειτουργίας των τοπικών αγορών ενέργειας για την ενίσχυση της ευελιξίας του δικτύου διανομής και της βελτίωσης της λειτουργίας του γενικότερου συστήματος ηλεκτρικής ενέργειας.
Understanding the Determinants of Secondhand Goods Buying Decisions: A Young Adult Consumers’ Perspective
Authors: Jibril Abdul Bashiru , Amoah John , Egala Sulemana Bankuoru , Odei Michael Amponsah
Published: July 2024

This paper delves into the influence of consumers’ perceptions of secondhand goods, encompassing factors such as perceived image, popularity, love, and loyalty on purchasing decisions within the retail market ecosystem, particularly in secondhand outlets. Drawing data from university students in Ghana, a demographic highly susceptible to secondhand goods in retail markets, we employ structural equation modeling techniques. The findings reveal that, within the context of retail markets, young adults’ perceptions significantly impact the decision-making process when it comes to secondhand goods. Four key antecedents emerged: perceived popularity, perceived image, perceived love, and perceived loyalty. Notably, perceived love exhibits a substantial effect on customers’ purchasing decisions, mediated by perceived loyalty. Furthermore, the study demonstrates that 72% of the variations in the outcome variable (buying decision) can be attributed to the identified perceptions associated with secondhand goods. This suggests that these perceptions effectively predict the consumer purchase decisions. Consequently, in secondhand retailing markets, marketing practitioners should prioritize understanding and appealing to consumers’ perceptions associated with the goods. The implications for both theory and practice are thoroughly discussed.
TREINAMENTO PARA PROFESSORES SOBRE ENVELHECIMENTO:
Authors: Dos Santos Jéssica Dellalibera , De Lima Flauzino Karina , Cachioni Meire
Published: July 2024

Com o objetivo de mapear os treinamentos existentes em educação para o envelhecimento para professores da educação básica, foi realizada uma revisão de escopo, em oito bases de dados eletrônicas em listas de referências, a fim de examinar como os programas de treinamentos para os professores estão sendo conduzidos no campo da educação para o envelhecimento. De 1.090 registros iniciais, a síntese foi composta por 8 artigos científicos, que apresentaram as características mais frequentes dos treinamentos em termos de tipo de treinamento, duração, material didático utilizado, instrutores dos treinamentos, conteúdos, entre outros. Verifica-se que não há consenso em relação à estrutura metodológica e didática dos programas de treinamento em educação para o envelhecimento. Em conclusão, os treinamentos devem ser realizados atendendo às necessidades da população longeva e às políticas de educação básica vigentes, compreendendo que, para avaliar o impacto dos treinamentos, é necessário o desenvolvimento de instrumentos próprios para essa finalidade, bem como metodologias que atendam aos interesses e necessidades dos professores de educação básica. Principalmente, devem-se desenvolver atitudes positivas em relação à velhice e ao envelhecimento.
Assessment and examination of the respiratory system
Authors: Bone Helen , Diamond-Fox Sadie
Published: July 2024

This article aims to outline the fundamental principles of consultations with and clinical assessments of patients with symptoms that may be indicative of respiratory system pathology. The article explores how to perform a respiratory system-focused patient history and physical examination. An evaluation of clinical ‘red flags’ to reduce the risk of omitting serious illness is also considered, alongside the exploration of features of respiratory pathology and evidence-based clinical decision-making tools that may be used to support clinical diagnosis.
The ethics of clinically assisted nutrition and hydration in adults and the role of the advanced clinical practitioner
Authors: Alsararatee Hasan Hazim
Published: July 2024

Clinically assisted nutrition and hydration (CANH) decision-making in adult patients presents complex ethical dilemmas that require careful consideration and navigation. This clinical review addresses the multifaceted aspects of CANH, emphasising the importance of ethical frameworks and the role of advanced clinical practitioners (ACPs) in guiding decision-making processes. The pivotal role of ACPs is highlighted, from their responsibilities and challenges in decision-making to the collaborative approach they facilitate involving patients, families and multidisciplinary teams. The article also explores ethical principles such as autonomy, beneficence, non-maleficence, and justice, elucidating their application in CANH decision-making. Legal and ethical frameworks covering CANH are examined, alongside case studies illustrating ethical dilemmas and resolutions. Patient-centred approaches to CANH decision-making are discussed, emphasising effective communication and consideration of cultural and religious beliefs. End-of-life considerations and palliative care in CANH are also examined, including the transition to palliative care and ethical considerations in withdrawal or withholding of CANH. Future directions for research and implications for clinical practice are outlined, highlighting the need for ongoing ethical reflection and the integration of ACPs in CANH decision-making.
Selective Synthesis of Imines via Oxidative Coupling of Primary Amines and Oxidation of Secondary Amines by Peroxides and other Competent Oxidants: A Short Review
Authors: Ravula Madhu , Bandalla Siddaramagoud , Dosarapu Vijaykumar , Kurra Mohan , Mavurapu Satyanarayana , Vasam Chandra Sekhar
Published: July 2024

Imines are certainly important constituents of many biomolecules, pharmaceuticals, agrochemicals, and fine chemicals. This review article highlights the standard protocols reported so far for the selective synthesis of imines via catalyzed and non-catalyzed (i) oxidative coupling of primary amines and (ii) oxidation of secondary amines in the presence of some competent/resourceful oxidants other than molecular O2 such as tert-butyl hydroperoxide (TBHP), H2O2, hypervalent iodines, persulfate, hypochlorite, electroactive species and graphene oxide. Indeed, the use of such oxidants offers a cost-effective experimental set-up, operational simplicity and also minimization of by-products. The cooperativity between catalyst, amine substrate, and oxidant is discussed in this review to understand the proposed mechanisms. Three consolidated data tables (Table 1, 2 & 3) are prepared to provide the summary of optimized reaction conditions (type of catalyst, type of oxidant, choice of solvent, amine-to-oxidant ratio, reaction time/temperature, conversion of amine, yield/selectivity of imine) of each article published to have a comparison.
Studies on Minimization of Pollutants from Sugar Industry Effluent by Using a Combination of Metal Coagulant and Polymer
Authors: Kaushish Payal , D Drishti , Jabin Shagufta , Chawla Jyoti , Gupta Priti
Published: July 2024

World is facing lot of health issues due to industrial wastewater pollution. Increasing population and industrialization are one of the main causes of water pollution. In general, industrial wastewater contains suspended, colloidal and dissolved impurities. Industrial effluent may be either excessively acidic or alkaline and may contain high concentration of coloured matter. In this study, coagulation-flocculation method has been used for minimization of contaminants from sugar industry effluent. Lime has been used in conjunction with poly diallyl dimethyl ammonium chloride (PDADMAC) for reduction of chemical oxygen demand (COD), total dissolved solids (TDS), total suspended solids (TSS) and turbidity. It could remove 97% turbidity, 92.8 % TSS, 95.5% TDS and 90.5% COD from sugar industry wastewater. Scanning electron microscopy (SEM) studies were also performed to support the formation of flocs.
Theoretical and Experimental Study of Structural Aspects of 2-acetonyl-2-methyl Benzothiazoline
Authors: Laxmi K.
Published: July 2024

Schiffs base 2-acetonyl-2-methyl benzothiazoline (AMBT) is prepared by the condensation of acetyl acetone with 2-aminothiophenol .The compound has been characterised by IR, 1H NMR spectra. HyperChem 7.5 software is used to study the structural features of AMBT and theoretical data so obtained is compared with experimental spectral data. Quantum mechanical calculations were done by HyperChem 7.5 software. Ab Initio method is used for geometry optimization. Quantum calculation of molecular electronic structure and variables for Quantitative structure-activity relationships (QSAR) of AMBT were determined by applying Austin Model 1, or AM1 a semi-empirical method. Computation of HOMO and LUMO frontier orbital energies is also performed. The relationship between the structure and energy gap is studied. pH- metry studies confirm that in AMBT Molecule there exists only one proton which is dissociable
Kinetics Study of Acid Hydrolysis of Waste Polyamide-6,6 Using Sodium-1-heptane Sulphonate Surfactant
Authors: Sheikh Hoomaafrin A. R. , Madhamshettiwar Swapnil. V.
Published: July 2024

In this paper, the depolymerization of waste polyamide-6,6 by using sodium-1- heptane sulphonate as a catalyst was carried out by acid hydrolysis. This method provides the recycling of polyamide into its monomer derivative which is dibenzoyl derivative of hexamethylene diamine. Depolymerization was carried out at different time from 30 min to 180 min by using 0.03g of sodium-1- heptane sulphonate at 80oC by taking various amount of catalyst. Reaction takes place around 120 min to get 78.23 % yield of the product. The product was analyzed by its melting point (154 OC) and FTIR spectra and it was found to be same as the pure one. Kinetics shows pseudo first order with reaction rate constant 6.68 × 10-3 min -1.
Short Communication: Estimation of aboveground biomass and carbon sequestration in KGPAA Mangkunagoro I Grand Forest Park, Central Java, Indonesia
Authors: INDRIYANI SISCA , SARI SILVI PUSPITA , NEGARI SNADA INDAH TUK , PRAMBUDI SATRIA AJI , NUR ALYA AFRA INAS , KUSUMANINGRUM LIA , INDRAWAN MUHAMMAD , SUNARTO SUNARTO , SUGIYARTO SUGIYARTO , BUDIHARTA SUGENG , SETYAWAN AHMAD DWI
Published: July 2024

Abstract. Indriyani S, Sari SP, Negari SIT, Prambudi SA, Nur AAI, Kusumaningrum L, Indrawan M, Sunarto, Sugiyarto, Budiharta S, Setyawan AD. 2024. Short Communication: Estimation of aboveground biomass and carbon sequestration in KGPAA Mangkunagoro I Grand Forest Park, Central Java, Indonesia. Biodiversitas 25: 2257-2263. Forests play an important role in climate change mitigation by absorbing carbon dioxide in the atmosphere and store it in the form of biomass. Valuation of carbon storage potential of a forest will provide insight on the importance of preserving it. This study aims to assess plant diversity and estimate aboveground biomass, carbon stocks, carbon dioxide sequestration potential, and the economic value of ecosystem services from carbon sequestration in KGPAA Mangkunagoro I Grand Forest Park, Central Java, Indonesia. We used a non-destructive method (i.e. allometric equation) in estimating aboveground biomass and carbon stock. We established 50 sampling plots to identify and measure trees (DBH >20 cm) and poles (10<DBH<20 cm). The results showed that there were 30 species from 20 families found in the observation plots. The potential aboveground biomass at the tree and pole level was 297.92 tons/ha and 57.22 tons/ha, respectively, while the total carbon stock for tree and pole was 140.02 tons/ha and 26.89 tons/ha, respectively. This was equivalent to carbon dioxide sequestration of 513.88 tons/ha and 98.70 tons/ha for trees and poles. The economic value of environmental services from carbon stock in the whole area of KGPAA Mangkunagoro I Grand Forest Park was estimated at IDR 21,289,040,253. The results of this research show that apart from playing a role in mitigating climate change by absorbing carbon, KGPAA Mangkunagoro I Grand Forest Park also has valuable economic value.
July 2024 Medical Image of the Month: Vocal Cord Paralysis on PET-CT
Authors: Ali Abdulmonam ,   SSM Health, Mount Vernon, IL USA
Published: July 2024

No abstract available. Article truncated after 150 words. A 60-year-old woman with a past medical history of hypertension, rheumatoid arthritis, and a significant smoking history (40+ pack-years) presented with a 3-month history of hoarseness of voice as well as a 10 lb weight loss over a 5-month period. Chest CT revealed a spiculated left upper lobe nodule (Figure 1A). Additionally, there was evidence of bulky mediastinal and left hilar lymphadenopathy (Figure 1B). A subsequent 17-FDG PET-CT (Figure 2) demonstrated marked metabolic activity in the left upper lobe nodule with an SUV maximum of 9.1. Metabolically active mediastinal and left hilar lymphadenopathy was also noted with an SUV maximum of 5.9. Interestingly, increased metabolic activity of the right vocal cord compared to the left was noted on the PET scan (Figure 2B). Direct laryngoscopy, performed during intubation for a diagnostic bronchoscopy and endobronchial ultrasound, confirmed left vocal cord paralysis. EBUS sampling of multiple mediastinal hilar lymph node stations, including …
Conflictividad laboral en el capitalismo de plataforma: retos y oportunidades para sindicalismo en España
Authors: Fernández-Trujillo Moares Francisco José
Published: July 2024

Con la proliferación del fenómeno de las plataformas digitales como mecanismo neoliberal de reorganización del trabajo, no solo sus trabajadoras y trabajadores y el sindicalismo se encuentran ante nuevo reto. Las nuevas formas laborales asociadas a estas plataformas y las vías de evasión de los marcos del trabajo llegadas con el capitalismo de plataforma han supuesto la proliferación de nuevos desafíos sociales que han derivado en normativas y marcos jurídicos desde los que enfrentar esta nueva realidad.
Si atendemos a las formas de resistencia en el ámbito del trabajo en las plataformas digitales no podemos limitar la mirada a los recursos y formas sindicales tradicionales, sino que es necesaria una apertura a experiencias, alianzas y exploración de las oportunidades políticas que se han dado en los últimos años.
Debemos considerar que la puesta en marcha de fórmulas de negociación, representación o resistencia en el escenario de las plataformas digitales son especialmente complejas, en tanto que se da un sumatorio de factores desfavorables para la acción sindical, como son la dimensión global de las compañías de plataforma, la incorporación de trabajadoras y trabajadores migrantes con dificultades para la acción sindical tradicional, la configuración de la organización del trabajo, que genera incomunicación y aislamiento entre las trabajadoras y trabajadores o las habituales relaciones de trabajo atípicas que les han venido caracterizando y que han profundizado en buena medida estos rasgos de individualización y precariedad.
Aquí se exponen algunos de los retos que encuentra el sindicalismo y algunas de las estrategias y prácticas que he han llevado a cabo en los últimos años en España para afrontar estas nuevas realidades en el conflicto laboral.
Industry, Photography, Representations: Portugal, 1897-1914
Authors: Pereira Hugo Silveira
Published: July 2024

In late nineteenth century and in the first two decades of the twentieth century, Portugal witnessed a modest industrial growth. This industrialisation process was recorded by thousands of photographs, many of which were published in the illustrated press. In this article, I analyse how Portuguese industry was represented by photography and how that representation was disseminated nationwide through the publication of photographs in the two most important illustrated magazines of that period: O Occidente and Illustração Portugueza. I rely on a methodology combining semiotics with discourse analysis in journalism. I show that both magazines built an industrial landscape of modernity and progress, which did not coincide with the real condition of Portuguese industry. I add to the discussion advocating photography as an historical source, arguing that it is much more than a mere illustrative support, but a reliable primary source, with a high potential for history in general, and for the fields of business and industrial history in particular, in the sense that photography can provide fresh narratives around technological change.
Resurrecting a Trope: Asian-American Students, Bullying and the COVID-19 Pandemic
Authors: Mendoza Robert
Published: July 2024

Abstract: This paper will be seeking to answer the following question: What impact has the COVID-19 pandemic had on the relationship between Asian students and bullying? This research uses a theoretical framework based on Asian Critical Race Theory and intersectionality and uses a quantitative logistic regression-based analysis to understand how variables pertaining to Violent Behavior, Mental Health and Key Demographic factors impact the chances of an Asian student experiencing Bullying, considering the unique social context that the COVID-19 pandemic and subsequent quarantine created. This research took place as part of the Center for Disease Control (CDC) one-time, online adolescent behaviors and experiences survey (ABES) on the effects of the COVID-19 pandemic on a variety of social behaviors among members of the high school student population. The result’s reveal pronounced variation within this population in relation to their chances of experiencing bullying, with queer identity, fighting, and Mental Health playing differential roles depending on the respondent’s gender identity. The study concludes that these inter-and intragroup differences in the results between differently gendered Asian individuals justify further intersectional research on the issues of bullying and peer to peer violence in the light of the COVID-19 pandemic moving forward.
Financial Technology (Fintech) as a Driver for Poverty Reduction in Nigeria
Authors: Boloupremo Tarila , Ogege Samson
Published: July 2024

ABSTRACT: The human race has been confronting the issue of poverty which is threatening its continued existence for a long time. Poor access to finance can lead to poverty this breeds health issues, lack of access to social and recreational facilities, social delinquencies, reduced living standard, malnutrition and economic difficulties. The goal of defeating poverty in its various ramification remains a cardinal concern for policy formulators in the Nigerian state and international bodies such as the World Bank and United Nations. Following the thriving emergence of financial technology (fintech) in Nigeria, there exist a dearth in academic researches to examine how fintech can be a driver in the reduction of poverty. This study examined the impact of financial technology on poverty reduction in Nigeria. Data on poverty rate, financial technology, mortality rate, literacy rate and gross domestic products were obtained from the National Bureau of Statistics (NBS) in Nigeria and the Central Bank of Nigeria (CBN) statistical bulletin for the period of 1991 – 2021. This study employed the multiple linear regression estimation technique to analyse collected data as it examines a cross-section of major key independent variables across a time series data, on the premise of a common effect model. Data analysed indicates a negative and significant nexus between poverty rate and financial technology innovation. The result also suggest that literacy rate and poverty rate have a negative and insignificant relationship. The poverty rate was also found to be positively and insignificantly related to mortality rate and gross domestic products respectively. The study findings have several significant policy implications. Firstly, infrastructures that support internet and mobile telephony should be expanded by providing incentives for investment since technology is the backbone of the operations of fintech. Secondly, education on fintech, information communication technology and finance should be increased to fill the gap among citizens who are not technological inclined especially in the rural areas to increase the use of fintech. Lastly, there should be further regulatory interventions through reforms to remove the barriers to credit.
Effects of Conflict-Induced Food Price Shocks on Food Security Outcomes of the Households in Nigeria
Authors: Adekunle Chioma Patricia , Papa Kao , Akinbode Sakiru Oladele , Ndoye Edmee
Published: July 2024

ABSTRACT: Among major development organizations, the unchallenged consensus is that war and conflict are development issues ravaging local economies, often leading to forced migration, refugee populations, and acute food insecurity. Food insecurity when caused by a rise in food prices is a threat for violent conflict. This study was conducted in Nigeria using three types of quantitative data which are the general household panel data, monthly retailed commodity prices, and violent conflict data from 2010 to 2019. This study examines the linkages between conflict, food price shocks, and food security outcomes of households in Nigeria. Per capita daily calorie intake, household dietary diversity, and per capita monthly food consumption were the three food security outcomes used for this study. Fixed effects panel regression models were used to determine the effects of conflict-induced food price shocks on the food security outcomes of households. I was found that dietary diversity appeared to be higher in the first wave than in the other three waves. The measure of dietary diversity for the post-harvests were slightly higher than the post-plantings. The high dietary diversity associated with the post-harvest periods is partly related to the relatively higher net value of foods consumed during the same season. This is because the amount of food calories consumed during the post-harvest periods are relatively lower than the amount consumed during the post-planting periods. Regardless of the conflict level in Nigeria, an increase in conflict-induced price shock of wheat, and rice is associated with a decline in calorie intake, dietary diversity, and the actual food value consumed. The conflict-induced price shocks of other cereals negatively influence the actual food value consumed, and dietary diversity. It is concluded that violent conflict influences some aspects of food insecurity, through adjustment in diets in response to price increases. Conflict-induced price shocks is a necessary condition for food security. Therefore, policy issues aimed at improving the food security outcomes of households in the face of conflict-induced price shocks should focus on price scheme that will stabilise price placing a price floor on food commodities.