bluuebunny/crossref_metadata_2025 huggingface dataset:
Prenatal Glucocorticoid Exposure Modifies Endocrine Function and Behaviour for 3 Generations Following Maternal and Paternal Transmission
Authors: Moisiadis Vasilis G. , Constantinof Andrea , Kostaki Alisa , Szyf Moshe , Matthews Stephen G.
Published: September 2017

Fetal exposure to high levels of glucocorticoids programs long-term changes in the physiologic stress response and behaviours. However, it is not known whether effects manifest in subsequent generations of offspring following maternal (MT) or paternal (PT) transmission. We treated pregnant guinea pigs with three courses of saline or synthetic glucocorticoid (sGC) at a clinically relevant dose. Altered cortisol response to stress and behaviours transmitted to juvenile female and male F2 and F3 offspring from both parental lines. Behavioural effects of sGC in F1-F3 PT females associated with altered expression of genes in the prefrontal cortex and hypothalamic paraventricular nucleus (PVN). Exposure to sGC programmed large transgenerational changes in PVN gene expression, including type II diabetes, thermoregulation, and collagen formation gene networks. We demonstrate transgenerational programming to F3 following antenatal sGC. Transmission is sex- and generation-dependent, occurring through both parental lines. Paternal transmission to F3 females strongly implicates epigenetic mechanisms of transmission.
Corona discharge induced snow formation in a cloud chamber
Authors: Ju Jingjing , Wang Tie-Jun , Li Ruxin , Du Shengzhe , Sun Haiyi , Liu Yonghong , Tian Ye , Bai Yafeng , Liu Yaoxiang , Chen Na , Wang Jingwei , Wang Cheng , Liu Jiansheng , Chin S. L. , Xu Zhizhan
Published: September 2017

Artificial rainmaking is in strong demand especially in arid regions. Traditional methods of seeding various Cloud Condensation Nuclei (CCN) into the clouds are costly and not environment friendly. Possible solutions based on ionization were proposed more than 100 years ago but there is still a lack of convincing verification or evidence. In this report, we demonstrated for the first time the condensation and precipitation (or snowfall) induced by a corona discharge inside a cloud chamber. Ionic wind was found to have played a more significant role than ions as extra CCN. In comparison with another newly emerging femtosecond laser filamentation ionization method, the snow precipitation induced by the corona discharge has about 4 orders of magnitude higher wall-plug efficiency under similar conditions.
Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients
Authors: Zhang Baohua , Han Mei , Tan Shuping , De Yang Fu , Tan Yunlong , Jiang Shurong , Zhang Xiangyang , Huang Xu-Feng
Published: September 2017

Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive functions can significantly affect the outcomes and daily life in patients. This study examined the gender differences of cognition using the measurement and treatment research to improve cognition in schizophrenia (MATRICS) consensus cognitive battery (MCCB), especially focusing on reasoning and problem solving, and social cognition in schizophrenia patients. The results showed that healthy controls exemplified better cognition than patients in both genders in all examined MCCB scores. Male healthy controls had better reasoning and problem solving and working memory than females, but these gender differences were not presented in schizophrenia patients. Also, male schizophrenia patients showed worse cognition than females on social cognition, processing speed, verbal learning and visual learning. Our results support that male schizophrenia patients had more cognitive impairment than females on reasoning and problem solving, social cognition, processing speed, working memory, verbal learning and visual learning.
Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires
Authors: Conant Genevieve , Ahadian Samad , Zhao Yimu , Radisic Milica
Published: September 2017

Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected during clinical trials. We hypothesize that more predictive cardiac functional assessments of kinase inhibitors on human myocardium can be established by combining a high-throughput two-dimensional (2D) screening assay and a high-content three-dimensional (3D) engineered cardiac tissue (BiowireTM) based assay, and using human induced pluripotent stem cell-derived CMs (hiPSC-CMs). A subset (80) of compounds from the GlaxoSmithKline published kinase inhibitor set were tested on hiPSC-CM monolayers and significant effects on cell viability, calcium transients, and contraction frequency were observed. Artificial neural network modelling was then used to analyze the experimental results in an efficient and unbiased manner to select for kinase inhibitors with minimal effects on cell viability and function. Inhibitors of specific interest based on the modeling were evaluated in the 3D Biowire tissues. The three-dimensional Biowire platform eliminated oversensitivity in detecting both Ca2+ transient amplitude enhancements as well as the acute detrimental effects on cell viability due to the kinase inhibitor application as compared to the monolayer testing.
Bio-butanol sorption performance on novel porous-carbon adsorbents from corncob prepared via hydrothermal carbonization and post-pyrolysis method
Authors: Han Mengjun , Jiang Kangkang , Jiao Pengfei , Ji Yingchun , Zhou Jingwei , Zhuang Wei , Chen Yong , Liu Dong , Zhu Chenjie , Chen Xiaochun , Ying Hanjie , Wu Jinglan
Published: September 2017

A series of porous-carbon adsorbents termed as HDPC (hydrochar-derived pyrolysis char) were prepared from corncob and used for the 1-butanol recovery from aqueous solution. The influences of pyrolysis temperature on properties of the adsorbents were systematically investigated. The results showed that hydrophobicity, surface area, and pore volume of HDPC samples increased with an increase in pyrolysis temperature. Furthermore, the adsorption mechanism of 1-butanol on the adsorbents was explored based on correlation of the samples properties with adsorption parameters extracted from the 1-butanol adsorption isotherms (K
F
and Q
e12
). Overall, the 1-butanol adsorption capacity increased with a decrease in polarity and an increase in aromaticity, surface area and pore volume of HDPC samples. However, at different pyrolysis temperature, the factors causing the increase of 1-butanol adsorption on the adsorbents are variable. The kinetic experiments revealed that the pores played a vital role in the 1-butonal adsorption process. The intraparticle diffusion model was used to predict the adsorption kinetic process. The simulation results showed that intraparticle diffusion was the main rate-controlling step in the 1-butanol adsorption process.
Two Step Excitation in Hot Atomic Sodium Vapor
Authors: Docters Bernd , Wrachtrup Jörg , Gerhardt Ilja
Published: September 2017

A two step excitation scheme in hot atomic sodium vapor is experimentally investigated. The observed effects reflect a coupling between the 32S, 32P and the 32D states. We present the relative dependence on detuning of the two utilized lasers around λ = 589 nm and 819 nm. Unlike expected, we achieve a higher detuning dependence of the probe and the coupling laser by a factor of approximately three. The presented work aimed for a Rydberg excitation and quantum light storage. Such schemes are usually implemented with a red laser on the D-line transition and a coupling laser of shorter (typically blue) wavelength. Due to the fact that higher P-Rydberg states are approximately two times higher in energy than the 32D state, a two photon transition from the atomic excited 32P state to a Rydberg P state is feasible. This might circumvent laser frequency doubling whereby only two lasers might mediate a three photon process. The scheme of adding three k-vectors allows for electromagnetically induced transparency experiments in which the resulting k-vector can be effectively reduced to zero. By measurements utilizing electric fields and an analysis of the emission spectrum of the atomic vapor, we can exclude the excitation of the P-P two photon transition.
Refinement of ectopic protein expression through the GAL4/UAS system in Bombyx mori: application to behavioral and developmental studies
Authors: Hara Chiho , Morishita Koudai , Takayanagi-Kiya Seika , Mikami Akihisa , Uchino Keiro , Sakurai Takeshi , Kanzaki Ryohei , Sezutsu Hideki , Iwami Masafumi , Kiya Taketoshi
Published: September 2017

Silkmoth, Bombyx mori, is one of the important model insects in which transgenic techniques and the GAL4/UAS system are applicable. However, due to cytotoxicity and low transactivation activity of GAL4, effectiveness of the GAL4/UAS system and its application in B. mori are still limited. In the present study, we refined the previously reported UAS vector by exploiting transcriptional and translational enhancers, and achieved 200-fold enhancement of reporter GFP fluorescence in the GAL4/UAS system. Enhanced protein expression of membrane-targeted GFP and calcium indicator protein (GCaMP5G) drastically improved visualization of fine neurite structures and neural activity, respectively. Also, with the refined system, we generated a transgenic strain that expresses tetanus toxin light chain (TeTxLC), which blocks synaptic transmission, under the control of GAL4. Ectopic TeTxLC expression in the sex pheromone receptor neurons inhibited male courtship behavior, proving effectiveness of TeTxLC on loss-of-function analyses of neural circuits. In addition, suppression of prothoracicotropic hormone (PTTH) or insulin-like peptide (bombyxin) secretion impaired developmental timing and growth rate, respectively. Furthermore, we revealed that larval growth is sex-differentially regulated by these peptide hormones. The present study provides important technical underpinnings of transgenic approaches in silkmoths and insights into mechanisms of postembryonic development in insects.
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD
Authors: York Brian , Li Feng , Lin Fumin , Marcelo Kathrina L. , Mao Jianqiang , Dean Adam , Gonzales Naomi , Gooden David , Maity Suman , Coarfa Cristian , Putluri Nagireddy , Means Anthony R.
Published: September 2017

Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca2+/CaM-dependent protein kinases. CaMKK2 (Ca2+/CaM-dependent protein kinase kinase 2) is a central member of this kinase family as it controls the actions of a CaMK cascade involving CaMKI, CaMKIV or AMPK. CaMKK2 controls insulin signaling, metabolic homeostasis, inflammation and cancer cell growth highlighting its potential as a therapeutic target for a variety of diseases. STO-609 is a selective, small molecule inhibitor of CaMKK2. Although STO-609 has been used extensively in vitro and in cells to characterize and define new mechanistic functions of CaMKK2, only a few studies have reported the in vivo use of STO-609. We synthesized functional STO-609 and assessed its pharmacological properties through in vitro (kinase assay), ex vivo (human liver microsomes) and in vivo (mouse) model systems. We describe the metabolic processing of STO-609, its toxicity, pharmacokinetics and bioavailability in a variety of mouse tissues. Utilizing these data, we show STO-609 treatment to inhibit CaMKK2 function confers protection against non-alcoholic fatty liver disease. These data provide a valuable resource by establishing criteria for use of STO-609 to inhibit the in vivo functions of CaMKK2 and demonstrate its utility for treating metabolically-related hepatic disease.
Longitudinal Association of Sleep Duration with Depressive Symptoms among Middle-aged and Older Chinese
Authors: Li Yujie , Wu Yili , Zhai Long , Wang Tong , Sun Yongye , Zhang Dongfeng
Published: September 2017

This study aimed to evaluate the associations of nighttime sleep duration and midday napping with risk of depressive symptoms incidence and persistence among middle-aged and older Chinese. Data from China Health and Retirement Longitudinal Study, CHARLS (2011–2013), were analyzed. Depressive symptoms were identified by the 10-item version of the Centre for Epidemiological Studies Depression scale (CESD-10). Multivariate binary logistic regression models were fitted. There were 7156 individuals with CESD-10 scores < 10 and 3896 individuals with CESD-10 scores ≥ 10 at baseline included in this study. After controlling for potential covariates, nighttime sleep duration <6 hours was associated with high risk of incident depressive symptoms (OR = 1.450, 95%CI: 1.193, 1.764 for middle aged population, and OR = 2.084, 95%CI:1.479, 2.936 for elderly) and persistent depressive symptoms (OR = 1.404, 95%CI: 1.161, 1.699 for middle aged population, and OR = 1.365, 95%CI: 0.979, 1.904 for elderly). For depressed individuals, longer midday napping (≥60 minutes) was associated with lower persistent depressive symptoms (OR = 0.842, 95%CI: 0.717, 0.989). Our study concluded that short nighttime sleep duration was an independent risk factor of depressive symptoms incidence and persistence. Depressed individuals with long midday napping were more likely to achieve reversion than those who have no siesta habit.
Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex
Authors: Homman-Ludiye Jihane , Kwan William C. , de Souza Mitchell J. , Rodger Jennifer , Bourne James A.
Published: September 2017

The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region. Furthermore, ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling in these cells recapitulating the abnormal neocortex observed in the knockout. The disturbance to the architecture of the neocortex observed following deletion of ephrin-A2 signaling shares many similarities with defects found in the neocortex of children diagnosed with autism spectrum disorder.
Chebulinic acid inhibits smooth muscle cell migration by suppressing PDGF-Rβ phosphorylation and inhibiting matrix metalloproteinase-2 expression
Authors: Song In-Sung , Jeong Yu Jeong , Park Jung-Hyun , Shim Sungbo , Jang Sung-Wuk
Published: September 2017

Excessive migration of vascular smooth muscle cells (VSMCs) after vascular injury contributes to the development of occlusive vascular disease. Inhibition of VSMC migration is a validated therapeutic modality for occlusive vascular diseases, such as atherosclerosis and restenosis. We investigated the inhibitory effect of chebulinic acid (CBA) on cell migration and matrix metalloproteinase (MMP)-2 activation in platelet-derived growth factor (PDGF)-BB-induced mouse and human VSMCs. CBA significantly inhibited PDGF-BB-induced migration in mouse and human VSMCs, without inducing cell death. Additionally, CBA significantly blocked PDGF-BB-induced phosphorylation of the PDGF receptor (PDGF-R), Akt, and extracellular signal-regulated kinase (ERK)1/2 by inhibiting the activation of the PDGF-BB signalling pathway. In both mouse and human VSMCs, CBA inhibited PDGF-induced MMP-2 mRNA and protein expression as well as the proteolytic activity of MMP-2. Moreover, CBA suppressed sprout outgrowth formation of VSMCs from endothelium-removed aortic rings as well as neointima formation following rat carotid balloon injury. Taken together, our findings indicated that CBA inhibits VSMC migration by decreasing MMP-2 expression through PDGF-R and the ERK1/2 and Akt pathways. Our data may improve the understanding of the antiatherogenic effects of CBA in VSMCs.
A Novel Mouse Model of Traumatic Optic Neuropathy Using External Ultrasound Energy to Achieve Focal, Indirect Optic Nerve Injury
Authors: Tao Wensi , Dvoriantchikova Galina , Tse Brian C. , Pappas Steven , Chou Tsung-Han , Tapia Manuel , Porciatti Vittorio , Ivanov Dmitry , Tse David T. , Pelaez Daniel
Published: September 2017

Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical scenario of closed head indirect trauma to the nerve and subsequent neurodegeneration. Thus, we developed a clinically-relevant animal model for TON using a novel ultrasonic pulse injury modality (sonication-induced TON; SI-TON). To trigger TON, a microtip probe sonifier was placed on the supraorbital ridge directly above the entrance of the optic nerve into the bony canal. An ultrasonic pulse was then delivered to the optic nerve. After injury, the number of RGCs in the retina as well as visual function measured by PERG steadily decreased over a two-week period. In the optic nerve, pro-inflammatory markers were upregulated within 6 hours following injury. Immunohistochemistry showed activation of microglia and infiltration of CD45-positive leukocytes in the optic nerve and initiation of a gliotic response. The SI-TON model is capable of delivering a non-contact concussive injury to the optic nerve and induce TON in mice. Thus, our data indicate that the SI-TON model reliably recapitulates the pathophysiology and progressive neurodegeneration seen in the human manifestation.
Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light
Authors: Einspahr Janine G. , Curiel-Lewandrowski Clara , Calvert Valerie S. , Stratton Steven P. , Alberts David S. , Warneke James , Hu Chengcheng , Saboda Kathylynn , Wagener Elisabeth L. , Dickinson Sally , Dong Zigang , Bode Ann M. , Petricoin Emanuel F.
Published: September 2017

Ultraviolet radiation is an important etiologic factor in skin cancer and a better understanding of how solar stimulated light (SSL) affects signal transduction pathways in human skin which is needed in further understanding activated networks that could be targeted for skin cancer prevention. We utilized Reverse Phase Protein Microarray Analysis (RPPA), a powerful technology that allows for broad-scale and quantitative measurement of the activation/phosphorylation state of hundreds of key signaling proteins and protein pathways in sun-protected skin after an acute dose of two minimal erythema dose (MED) of SSL. RPPA analysis was used to map the altered cell signaling networks resulting from acute doses of solar simulated radiation (SSL). To that end, we exposed sun-protected skin in volunteers to acute doses of two MED of SSL and collected biopsies pre-SSL and post-SSL irradiation. Frozen biopsies were subjected to laser capture microdissection (LCM) and then assessed by RPPA. The activation/phosphorylation or total levels of 128 key signaling proteins and drug targets were selected for statistical analysis. Coordinate network-based analysis was performed on specific signaling pathways that included the PI3k/Akt/mTOR and Ras/Raf/MEK/ERK pathways. Overall, we found early and sustained activation of the PI3K-AKT-mTOR and MAPK pathways. Cell death and apoptosis-related proteins were activated at 5 and 24 h. Ultimately, expression profile patterns of phosphorylated proteins in the epidermal growth factor receptor(EGFR), AKT, mTOR, and other relevant pathways may be used to determine pharmacodynamic activity of new and selective topical chemoprevention agents administered in a test area exposed to SSL to determine drug-induced attenuation or reversal of skin carcinogenesis pathways.
Fish and fishery historical data since the 19th century in the Adriatic Sea, Mediterranean
Authors: Fortibuoni Tomaso , Libralato Simone , Arneri Enrico , Giovanardi Otello , Solidoro Cosimo , Raicevich Saša
Published: September 2017

Historic data on biodiversity provide the context for present observations and allow studying long-term changes in marine populations. Here we present multiple datasets on fish and fisheries of the Adriatic Sea covering the last two centuries encompassing from qualitative observations to standardised scientific monitoring. The datasets consist of three groups: (1) early naturalists’ descriptions of fish fauna, including information (e.g., presence, perceived abundance, size) on 255 fish species for the period 1818–1936; (2) historical landings from major Northern Adriatic fish markets (Venice, Trieste, Rijeka) for the period 1902–1968, Italian official landings for the Northern and Central Adriatic (1953–2012) and landings from the Lagoon of Venice (1945–2001); (3) trawl-survey data from seven surveys spanning the period 1948–1991 and including Catch per Unit of Effort data (kgh−1 and/or nh−1) for 956 hauls performed at 301 stations. The integration of these datasets has already demonstrated to be useful to analyse historical marine community changes over time, and its availability through open-source data portal will facilitate analyses in the framework of marine historical ecology.
Database of multi-parametric geophysical data from the TOMO-DEC experiment on Deception Island, Antarctica
Authors: Ibáñez Jesús M. , Díaz-Moreno Alejandro , Prudencio Janire , Zandomeneghi Daria , Wilcock William , Barclay Andrew , Almendros Javier , Benítez Carmen , García-Yeguas Araceli , Alguacil Gerardo
Published: September 2017

Deception Island volcano (Antarctica) is one of the most closely monitored and studied volcanoes on the region. In January 2005, a multi-parametric international experiment was conducted that encompassed both Deception Island and its surrounding waters. We performed this experiment from aboard the Spanish oceanographic vessel ‘Hespérides’, and from five land-based locations on Deception Island (the Spanish scientific Antarctic base ‘Gabriel de Castilla’ and four temporary camps). This experiment allowed us to record active seismic signals using a large network of seismic stations that were deployed both on land and on the seafloor. In addition, other geophysical data were acquired, including bathymetric high precision multi-beam data, and gravimetric and magnetic profiles. To date, the seismic and bathymetric data have been analysed but the magnetic and gravimetric data have not. We provide P-wave arrival-time picks and seismic tomography results in velocity and attenuation. In this manuscript, we describe the main characteristics of the experiment, the instruments, the data, and the repositories from which data and information can be obtained.
Disrupted cortical brain network in post-traumatic stress disorder patients: a resting-state electroencephalographic study
Authors: Shim M , Im C-H , Lee S-H
Published: September 2017

This study aimed to examine the source-level cortical brain networks of post-traumatic stress disorder (PTSD) based on the graph theory using electroencephalography (EEG). Sixty-six cortical source signals were estimated from 78 PTSD and 58 healthy controls (HCs) of resting-state EEG. Four global indices (strength, clustering coefficient (CC), path length (PL) and efficiency) and one nodal index (CC) were evaluated in six frequency bands (delta, theta, alpha, low beta, high beta and gamma). PTSD showed decreased global strength, CC and efficiency, in delta, theta, and low beta band and enhanced PL in theta and low beta band. In low beta band, the strength and CC correlated positively with the anxiety scores, while PL had a negative correlation. In addition, nodal CCs were reduced in PTSD in delta, theta and low beta band. Nodal CCs of theta band correlated negatively with rumination and re-experience symptom scores; while, nodal CCs in low beta band correlated positively with anxiety and pain severity. Inefficiently altered and symptom-dependent changes in cortical networks were seen in PTSD. Our source-level cortical network indices might be promising biomarkers for evaluating PTSD.
Correction: Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples
Authors: García-Carmona Laura , Rojas Daniel , González María Cristina , Escarpa Alberto
Published: September 2017

Correction for ‘Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples by Laura García-Carmona et al., Analyst, 2016, 141, 6002–6007.
Hierarchical Co(OH)2nanotube arrays grown on carbon cloth for use in non-enzymatic glucose sensing
Authors: Huang M. , Luo X. , He D. , Jiang P.
Published: September 2017

Hierarchical Co(OH)2nanotube arrays grown on carbon cloth (Co(OH)2NTAs/CC) were prepared and utilized as a 3D binder-free electrode for non-enzymatic glucose sensing with high efficiency.
Catalytic domino amination and oxidative coupling of gold acetylides and isolation of key vinylene digold intermediates as a new class of ditopic N-heterocyclic carbene complexes
Authors: Chen Haifeng , Wang Jiwei , Hu Zejun , Xu Sheng , Shi Min , Zhang Jun
Published: September 2017

A catalytic domino amination and oxidative coupling of in situ prepared gold acetylides has been developed for the synthesis of abnormal NHC (aNHC) gold complexes, and key vinylene digold intermediates are isolated.
The relationship between the conformational degree of freedom of template-containing threads and slippage in the formation of [2]rotaxane building blocks
Authors: Riss-Yaw B. , Clavel C. , Laurent Ph. , Coutrot F.
Published: September 2017

Slippage is correlated with the degree of freedom of the molecular thread to be encircled. The straighter the thread, the faster is the slippage.
Unexpected formation of a tubular architecture by optically active pure organic calixsalen
Authors: Petryk Małgorzata , Janiak Agnieszka , Kwit Marcin
Published: September 2017

Herein, an unusual tubular formation of a supramolecular organic framework by optically active macrocyclic calixsalen is shown via single crystal X-ray diffraction.
Room-temperature NaI/H2O compression icing: solute–solute interactions
Authors: Zeng Qingxin , Yao Chuang , Wang Kai , Sun Chang Q. , Zou Bo
Published: September 2017

H–O bond energy governs thePCxfor Na/H2O liquid–VI–VII phase transition. Solute concentration affects the path of phase transitions differently with the solute type. Solute–solute interaction lessens thePC2sensitivity to compression. ThePC1goes along the liquid–VI boundary till the triple phase joint.
Symmetry and dynamics of FHF− anion in vacuum, in CD2Cl2 and in CCl4. Ab initio MD study of fluctuating solvent–solute hydrogen and halogen bonds
Authors: Pylaeva S. A. , Elgabarty H. , Sebastiani D. , Tolstoy P. M.
Published: September 2017

Asymmetric solvation of FHF− by halogen- and hydrogen-bonding solvents breaks the symmetry of the anion.
Running out of lithium? A route to differentiate between capacity losses and active lithium losses in lithium-ion batteries
Authors: Holtstiege Florian , Wilken Andrea , Winter Martin , Placke Tobias
Published: September 2017

Active lithium loss (ALL) resulting in a capacity loss (QALL), which is caused by lithium consuming parasitic reactions like SEI formation, is a major reason for capacity fading and, thus, for a reduction of the usable energy density of lithium-ion batteries (LIBs).
First principles studies of CO2 and O2 chemisorption on La2O3 surfaces
Authors: Wang Shibin , Cong Linna , Zhao Chengcheng , Li Yiting , Pang Yaoqi , Zhao Yonghui , Li Shenggang , Sun Yuhan
Published: September 2017

Periodic density functional theory calculations were performed to study the surface structures and stabilities of the La2O3 catalyst in CO2 and O2 environments, relevant to the conditions of the oxidative coupling of methane (OCM) reaction.
A ruthenium water oxidation catalyst containing a bipyridine glycoluril ligand
Authors: Mane Vishwanath S. , Kumbhar Avinash S. , Thummel Randolph P.
Published: September 2017

A mononuclear ruthenium complex [Ru(tpy)(bpg)H2O]2+ bearing a bipyridine glycoluril ligand (bpg) = 4b,5,7,7a-tetrahydro-4b,7a-nepiminomethan-oimino-6H-imidazo[4,5-f][1,10]phenanthroline-6,13-dione acts as a robust water oxidation catalyst (WOC) at pH = 1 using Ce(iv) as a sacrificial oxidant.
A novel stibacarbaborane cluster with adjacent antimony atoms exhibiting unique pnictogen bond formation that dominates its crystal packing
Authors: Holub Josef , Melichar Petr , Růžičková Zdeňka , Vrána Jan , Wann Derek A. , Fanfrlík Jindřich , Hnyk Drahomír , Růžička Aleš
Published: September 2017

The reaction ofarachno-4,6-C2B7H13with SbCl3yieldsnido-7,8,9,11-Sb2C2B7H9, which simultaneously has Sb–Sb, Sb–B and Sb–C bonds and a unique ability to form pnictogen bonds.
Gold nanorods decorated with a cancer drug for multimodal imaging and therapy
Authors: Nair Resmi V. , Santhakumar Hema , Jayasree Ramapurath S.
Published: September 2017

Drug conjugated gold nanorods for combined imaging and chemo-thermal therapy were evaluated using fluorescence and Raman techniques.
Microfluidic step-emulsification in axisymmetric geometry
Authors: Chakraborty I. , Ricouvier J. , Yazhgur P. , Tabeling P. , Leshansky A. M.
Published: September 2017

We present the combined numerical and experimental study of the axisymmetric co-flow step-emulsifier that closely mimics the planar microfluidic device.
Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity – a computational study
Authors: Tomin M. , Tomić S.
Published: September 2017

Dynamics and enzyme activity of dipeptidyl peptidase III, wild type and mutants, from the human gut symbiont Bacteroides thetaiotaomicron.
New insights into the spectral, thermal and morphological analysis of time dependent structural changes during open end functionalization of single walled carbon nanotubes
Authors: Elizabeth Roy Rinu , Soundiraraju Bhuvaneswari , Thomas Deepthi , Balachandran Nisha , Ambika Chithra , Rajeev R. S.
Published: September 2017

Acid functionalization inserts different types of functionalities on SWCNTs at different time intervals.
Anchoring di and tri-metallic nanoparticles on an amorphous functionalized surface for inducing photocatalytic activity
Authors: Khdary Nezar H. , Alkhuraiji Waleed S. , Ghanem Mohamed A. , Alqureshah Fahd A.
Published: September 2017

Surface functionalization chemistry was applied to immobilize di and tri metal nanoparticles on amorphous particles for an economically low-cost photocatalyst.
β-O-4 type dilignol compounds and their iron complexes for modeling of iron binding to humic acids: synthesis, characterization, electrochemical studies and algal growth experiments
Authors: Orlowska Ewelina , Enyedy Éva A. , Pignitter Marc , Jirsa Franz , Krachler Regina , Kandioller Wolfgang , Keppler Bernhard K.
Published: September 2017

A series of β-O-4 type dilignols and their iron(iii) complexes were evaluated as model compounds for humic acids.
Ultrathin β-tellurium layers grown on highly oriented pyrolytic graphite by molecular-beam epitaxy
Authors: Chen Jinglei , Dai Yawei , Ma Yaqiang , Dai Xianqi , Ho Wingkin , Xie Maohai
Published: September 2017

Molecular-beam epitaxy of ultrathin β-tellurium layers on highly oriented pyrolytic graphite.
Cancer vaccines using supramolecular hydrogels of NSAID-modified peptides as adjuvants abolish tumorigenesis
Authors: Wang Zhongyan , Liang Chunhui , Shi Fang , He Tao , Gong Changyang , Wang Ling , Yang Zhimou
Published: September 2017

We demonstrated in this study that supramolecular hydrogels of NSAID-modified peptides are promising adjuvants for cancer vaccine development.
Correction: Gold-loaded nanoporous iron oxide nanocubes: a novel dispersible capture agent for tumor-associated autoantibody analysis in serum
Authors: Yadav Sharda , Masud Mostafa Kamal , Islam Md. Nazmul , Gopalan Vinod , Lam Alfred King-yin , Tanaka Shunsuke , Nguyen Nam-Trung , Al Hossain Md. Shahriar , Li Cuiling , Yamauchi Yusuke , Shiddiky Muhammad J. A.
Published: September 2017

Correction for ‘Gold-loaded nanoporous iron oxide nanocubes: a novel dispersible capture agent for tumor-associated autoantibody analysis in serum’ by Sharda Yadav et al., Nanoscale, 2017, 9, 8805–8814.
Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells
Authors: Hong Jong-Ah , Choi Na-Eun , La Yeo-Kyoung , Nam Ho Yeon , Seo Jiwon , Lee Jiyoun
Published: September 2017

A smart activity-based probe that generates a turn-on fluorescence signal in response to enzyme activity was developed, allowing dynamic imaging of subcellular enzyme activity in living cells.
Synthesis of γ-keto sulfones by copper-catalyzed oxidative sulfonylation of tertiary cyclopropanols
Authors: Konik Yulia A. , Elek Gábor Zoltán , Kaabel Sandra , Järving Ivar , Lopp Margus , Kananovich Dzmitry G.
Published: September 2017

Preparation of γ-keto sulfones via ring-opening sulfonylation of cyclopropanols.
Stimuli-responsive circularly polarized luminescence from an achiral perylenyl dyad
Authors: Li Junfeng , Yang Chenglong , Peng Xuelei , Qi Qi , Li Yonghua , Lai Wen-Yong , Huang Wei
Published: September 2017

Stimuli-responsive circularly polarized luminescence (CPL) was successfully achieved through fine-tuning the conformation of a perylenyl dyad by using external stimuli.
RNA-directed off/on switch of RNase H activity using boronic ester formation
Authors: Reverte Maëva , Barvik Ivan , Vasseur Jean-Jacques , Smietana Michael
Published: September 2017

A new concept to modulate RNase H activity is presented based on the boronic acid/boronate switch.
AgOTf-catalyzed sequential synthesis of 4-isoquinolones via oxidative ring opening of aziridines and aza-Michael addition
Authors: Xing Siyang , Cui Hong , Gu Nan , Li Ying , Wang Kui , Tian Dawei , Qin Jiajing , Liu Qiaoyang
Published: September 2017

An efficient AgOTf-catalyzed sequential reaction involving the oxidative ring-opening of aziridines by DMSO and aza-Michael addition has been developed.
Synthesis and structure–property relationships of SIS-g-PB copolymers and their application in hot-melt pressure-sensitive adhesives
Authors: Zhao Zhongfu , Liu Peiying , Zhang Chunqing , Liu Wei , Ding Yifu , Zhang Yandong , Meng Fanzhi , Tang Tao
Published: September 2017

Grafting polybutadiene blocks onto epoxidized styrene-b-isoprene-b-styrene (ESIS) copolymers results in significant improvement of ESIS-based adhesives performance while retaining polarity.
Selective inhibition of cancer cells by enzyme-induced gain of function of phosphorylated melittin analogues
Authors: Li Qian-Qian , Chen Pu-Guang , Hu Zhi-Wen , Cao Yuan , Chen Liang-Xiao , Chen Yong-Xiang , Zhao Yu-Fen , Li Yan-Mei
Published: September 2017

Developing an enzyme-induced gain of function strategy to selectively kill cancer cells with high ALP activity.
Laboratory-scale photoredox catalysis using hydrated electrons sustainably generated with a single green laser
Authors: Naumann Robert , Kerzig Christoph , Goez Martin
Published: September 2017

A combined photokinetical approach helped develop and optimize a green-light driven photoredox catalytic system that generates a “super-reductant” with simple instrumentation, consumes only a bioavailable donor, and provides very high turnover numbers.
Flow-induced polymer separation through a nanopore: effects of solvent quality
Authors: Ding Mingming , Duan Xiaozheng , Shi Tongfei
Published: September 2017

Using a hybrid simulation method that combines a lattice-Boltzmann approach for the flow and a molecular dynamics model for the polymer, we investigated the effect of solvent quality on the flow-induced polymer translocation through a nanopore.
Carbohydrate-based block copolymer systems: directed self-assembly for nanolithography applications
Authors: Otsuka I. , Nilsson N. , Suyatin D. B. , Maximov I. , Borsali R.
Published: September 2017

Self-assembly of block copolymers (BCPs) provides an attractive nanolithography approach, which looks especially promising for fabrication of regular structures with characteristic sizes below 10 nm. Nevertheless, directed self-assembly (DSA) and pattern transfer for BCPs with such small features remain to be a challenge.
Trends in the phase stability and thermochemical oxygen exchange of ceria doped with potentially tetravalent metals
Authors: Jacot Roger , Moré René , Michalsky Ronald , Steinfeld Aldo , Patzke Greta R.
Published: September 2017

Screening of tetravalent dopants correlates dopant radius and oxygen exchange capacity for ceria optimization in solar thermochemical CO2reduction.
Squid suckerin microneedle arrays for tunable drug release
Authors: Ding Dawei , Pan Jing , Lim Seng Han , Amini Shahrouz , Kang Lifeng , Miserez Ali
Published: September 2017

We present microneedle arrays made of β-sheet rich suckerin proteins. The microneedles are produced using a straightforward soft lithography method and can be loaded with therapeutic agents that can be released in a tunable fashion.
A ruthenium-nitrosyl-functionalized nanoplatform for the targeting of liver cancer cells and NIR-light-controlled delivery of nitric oxide combined with photothermal therapy
Authors: Li Yan-Hui , Guo Min , Shi Shu-Wen , Zhang Qian-Ling , Yang Shi-Ping , Liu Jin-Gang
Published: September 2017

A multifunctional nanoplatform is capable of targeting liver cancer cells for NIR-light-controlled NO-release, and achieving both photodynamic and photothermal therapies.
Fluorescent carborane–vinylstilbene functionalised octasilsesquioxanes: synthesis, structural, thermal and photophysical properties
Authors: Cabrera-González Justo , Ferrer-Ugalde Albert , Bhattacharyya Santanu , Chaari Mahdi , Teixidor Francesc , Gierschner Johannes , Núñez Rosario
Published: September 2017

The functionalization of POSS with vinylstilbene–carborane moieties leads to tunable fluorescent hybrids with an outstanding thermal stability.
Efficient perovskite solar cells employing a simply-processed CdS electron transport layer
Authors: Dong Jia , Wu Jihuai , Jia Jinbiao , Fan Leqing , Lin Yu , Lin Jianming , Huang Miaoliang
Published: September 2017

In this report, redispersable CdS nanoparticles are synthesized via a specific one-step solvothermal reaction and are employed as electron-selective materials for organometal halide perovskite solar cells.
Relevance of the Implementation of Teeth in Three-Dimensional Vocal Tract Models
Authors: Traser Louisa , Birkholz Peter , Flügge Tabea Viktoria , Kamberger Robert , Burdumy Michael , Richter Bernhard , Korvink Jan Gerrit , Echternach Matthias
Published: September 2017

Purpose

Recently, efforts have been made to investigate the vocal tract using magnetic resonance imaging (MRI). Due to technical limitations, teeth were omitted in many previous studies on vocal tract acoustics. However, the knowledge of how teeth influence vocal tract acoustics might be important in order to estimate the necessity of implementing teeth in vocal tract models. The aim of this study was therefore to estimate the effect of teeth on vocal tract acoustics.

Method

The acoustic properties of 18 solid (3-dimensional printed) vocal tract models without teeth were compared to the same 18 models including teeth in terms of resonance frequencies (
f
Rn
). The
f
Rn
were obtained from the transfer functions of these models excited by white noise at the glottis level. The models were derived from MRI data of 2 trained singers performing 3 different vowel conditions (/i/, /a/, and /u/) in speech and low-pitched and high-pitched singing.

Results

Depending on the oral configuration, models exhibiting side cavities or side branches were characterized by major changes in the transfer function when teeth were implemented via the introduction of pole-zero pairs.

Conclusions

To avoid errors in modeling, teeth should be included in 3-dimensional vocal tract models for acoustic evaluation.

Supplemental Material

https://doi.org/10.23641/asha.5386771
Writing in Two Children With Autism: A Case Study for Assessment and Goal Development
Authors: Koutsoftas Anthony D.
Published: September 2017

Purpose

Writing is an important consideration for children with an Autistic Spectrum Disorder (ASD), especially when included in general education environments. This case study of an inclusive classroom provides a comprehensive description of writing processes allowing for demonstration of an assessment procedure and goal development. The case studied is a 6th grade inclusion classroom whereby 2 students were included and diagnosed with an ASD, their typically developing classmates served as a control group.

Method

One 6th grade classroom participated in this study and included 2 children receiving services for ASD and 15 classmates. Children completed a 3-day writing process task whereby they planned, wrote, and revised a narrative story on three separate days.

Results

Individual writing profiles of children with ASD revealed writing process skills consistent with each child's cognitive-linguistic learning profile.

Discussion

Findings from this study highlight the need to use cognitive linguistic profiles alongside writing samples to develop appropriate and attainable IEP goals for children with ASD. Implications for assessment, IEP goal development, and future directions for research and intervention are provided with particular focus on inclusive classroom settings.
Identification of linearised RMS‐voltage dip patterns based on clustering in renewable plants
Authors: García‐Sánchez Tania , Gómez‐Lázaro Emilio , Muljadi Edward , Kessler Mathieu , Muñoz‐Benavente Irene , Molina‐García Angel
Published: September 2017

Generation units connected to the grid are currently required to meet low‐voltage ride‐through (LVRT) requirements. In most developed countries, these requirements also apply to renewable sources, mainly wind power plants and photovoltaic installations connected to the grid. This study proposes an alternative characterisation solution to classify and visualise a large number of collected events in light of current limits and requirements. The authors’ approach is based on linearised root‐mean‐square‐(RMS)‐voltage trajectories, taking into account LRVT requirements, and a clustering process to identify the most likely pattern trajectories. The proposed solution gives extensive information on an event's severity by providing a simple but complete visualisation of the linearised RMS‐voltage patterns. In addition, these patterns are compared to current LVRT requirements to determine similarities or discrepancies. A large number of collected events can then be automatically classified and visualised for comparative purposes. Real disturbances collected from renewable sources in Spain are used to assess the proposed solution. Extensive results and discussions are also included in this study.
Algebraic solution for three‐dimensional TDOA/AOA localisation in multiple‐input–multiple‐output passive radar
Authors: Noroozi Ali , Sebt Mohammad Ali
Published: September 2017

The problem of estimating the location of a single target from time difference of arrival (TDOA) and angle of arrival (AOA) measurements using multi‐transmitter multi‐receiver passive radar system with widely separated antennas is discussed. A closed‐form two‐step target position estimator is presented and analysed. Using the measured AOAs, the method is able to resolve the weakness of the TDOA‐based methods in estimating the target height. Several weighted least‐squares minimisations are employed by the method to produce a location estimate. A weighting matrix in each step is employed to provide a significant improvement in the performance of the algorithm. The Cramer–Rao lower bound (CRLB) for target localisation accuracy is also developed. The proposed estimator is analytically shown to reach the CRLB for Gaussian TDOA and AOA noises at moderate noise level. Simulation studies indicate that the proposed hybrid TDOA/AOA location scheme performs better than any of the other algorithms, especially in the z‐direction.
One-Pot Synthesis of α,β-Unsaturated Esters, Ketones, and
Nitriles from Alcohols and Phosphonium Salts
Authors: Yu Xiaochun , Wang Shun , Ding Weijie , Hu Juan , Jin Huile
Published: September 2017

A general method for the synthesis of α,β-unsaturated esters, ketones, and nitriles is successfully achieved by a one-pot copper-catalyzed oxidation with O2 in air as oxidant. The solvent mixture of acetonitrile and formamide (1:1) is optimized to ensure the oxidation of alcohols, deprotonation of phosphonium salt, and Wittig reaction occur efficiently in one pot. A broad range of substrates has been explored for this process, including three electron-withdrawing group (CO2Et, COPh, CN) functionalized phosphonium salts. They reacted not only with benzylic and heteroaromatic alcohols, but also with aliphatic alcohols, forming the corresponding α,β-unsaturated esters, ketones, and nitriles in moderate to excellent yields.
New Strategy for Forging Contiguous Quaternary Carbon Centers via H2O2-Mediated Ring Contraction
Authors: Xie Weiqing , Hu Jiadong , Yu Xin
Published: September 2017

Stereospecific construction of contiguous quaternary carbon centers constitutes a major challenge in natural product synthesis. A general protocol that enables stereospecific construction of all stereoisomers of such a moiety remains elusive. In this article, we will discuss the oxidative ring contraction of all-substituted cyclic α-formyl ketones mediated by H2O2, which provides a facile access to the stereospecific construction of contiguous quaternary carbon centers.
Pituitary Adenoma Presenting As Trigeminal Neuralgia
Authors: Wani Abrar , Ramzan Altaf , Khan Abdul , Malik Nayil , Pervez Khalid
Published: September 2017

Compression of trigeminal nerve in cavernous sinus leading to trigeminal neuralgia is one of the rare presentations of pituitary tumor. We report a patient whose presenting complaint was trigeminal neuralgia in V1, V2 distribution and he had pituitary macroadenoma invading ipsilateral cavernous sinus. After surgery, the neuralgia disappeared completely.
Breaking International Barriers: #ColorectalSurgery Is #GlobalSurgery
Authors: Otero Jaime , Mayol Julio
Published: September 2017

Colorectal surgeons have lagged behind other professionals in the use of social media. Currently, Twitter is the most widely utilized social platform for professional purposes among them. Connection and contagion are the two key actions that, together with immediate feedback and quantifiable impact, favor the use of Twitter over other social networks. In early 2016, a group of colorectal surgeons launched the #colorectalsurgery hashtag and, in less than 1 year, the ecosystem has incorporated over 2,600 users that generated over 24,000 tweets and 100 million impressions. “Live-Tweeting” surgical conferences by attendees including institutional or society accounts have greatly contributed to the success of the initiative. However, there are some barriers to a more wide adoption of social media, such as misrepresentation of non–peer-reviewed data, challenges to intellectual property protection, or even damage to the professional image. Active engagement with the #colorectalsurgery community may result in benefits for the global surgery community through information sharing, social interactions, personal branding, and research.