bluuebunny/crossref_metadata_2025 huggingface dataset:
KORELASI ANTARA AKTIVITAS ADENOSINE DEAMINASE (ADA) CAIRAN PLEURA DAN HASIL LEUKOSIT CAIRAN PLEURA PADA PENDERITA EFUSI PLEURA
Authors: Patria Dewi Pande Putu Ayu , Aryati Aryati , Anniwati Leonita , Marhana Isnin Anang
Published: January 2024

Efusi pleura merupakan kumpulan cairan abnormal di ruang pleura. Diagnosis efusi pleura selain berdasarkan keluhan dan gejala klinis memerlukan berbagai pemeriksaan penunjang seperti radiografi, analisis cairan pleura. Adenosine deaminase merupakan enzim yang terlibat pada proses katabolisme purin. Enzim ini memegang peranan penting pada diferensiasi sel limfoid. Pemeriksaan aktivitas adenosine deaminase (ADA) telah lama digunakan sebagai penunjang diagnosis tuberkulosis karena cepat, murah, dan memiliki sensitivitas dan spesifisitas yang tinggi. Pemeriksaan analisis cairan pleura masih menjadi pemeriksaan utama pada penderita dengan efusi pleura untuk membantu penegakan diagnosis dan etiologi efusi pleura. Penelitian ini bertujuan untuk membandingkan aktivitas ADA cairan pleura dan hasil leukosit cairan pleura pada penderita efusi pleura. Jenis penelitian adalah penelitian observasional cross-sectional. Pemeriksaan aktivitas ADA dilakukan pada cairan pleura. Pemeriksaan aktivitas ADA dikerjakan dengan metode fotometri (cara Non Giusti) menggunakan reagen Diazyme dengan alat TMS 24i Premium. Pemeriksaan hitung sel leukosit menggunakan metode otomatis dengan prinsip flow cytometry menggunakan laser optic dengan alat Sysmex XN-1000. Subyek penelitian adalah 40 pasien efusi pleura dengan diagnosis keganasan, tuberkulosis, dan penyakit sistemik. Hasil analisis menunjukkan terdapat korelasi antara aktivitas ADA pada cairan pleura dan hitung sel leukosit untuk seluruh subyek penelitian (r = 0,495 dan p = 0,001). Korelasi antara aktivitas ADA pada cairan pleura dengan sel polimononuklear didapatkan r=0,521 dengan p = 0,001 sedangkan korelasi positif tidak bermakna ditunjukkan antara aktivitas ADA pada cairan pleura dengan sel mononuclear dengan r=0,228 dan p=0,157

Kata kunci. Adenosine deaminase, cairan pleura, leukosit
The Effect of Electronic Cigarettes (E-Cigarettes) and Conventional Smoke on the Trachea and Heart of Male White Rats
Authors: Andari Desy , Kharimah Yusrotun , Harianja Ade Friskilla , Pravitasari Dwi Nurwulan
Published: January 2024

Electronic cigarettes (e-cigarette) smoker was increasing from 0.3% in 2011 to 2.5% in 2015. E-cigarettes claimed to be safe for smoker, but subsequent research has shown that e-cigarette smoke also contains harmful ingredients beside nicotine, like carbon monoxide (CO). These contents presumed to increase the goblet cells in the trachea and can cause myocardial ischemia in the left ventricle of the heart which leads to necrosis. This study was conducted to determine the effect of e-cigarette and conventional cigarette smoke on tracheal goblet cells and left ventricular necrosis of the heart of male white rats (Rattus norvegicus strain wistar). Experimental study with post-test control only group design. 16 rats were divided into 4 groups: normal group, conventional cigarette group (kretek) with 2.3 mg nicotine, 3 mg nicotine e-cigarette, and 0 mg nicotine e-cigarette. Trachea and heart of rats were prepared using HE-staining and observed with a light microscope with 400x magnification. All data were analyzed using One-way ANOVA, Kruskall Wallis and Post-Hoc tests. Cigarette smoke had a significant effect on tracheal goblet cell (ANOVA p=0.000) and left ventricular necrosis of the heart (Kruskal Wallis p=0.002). Post-Hoc test showed a significant difference in the number of goblet cells and left ventricular necrosis of the heart (p (-- removed HTML --) 0.005). This is due to the toxic materials such as carbon monoxide, propylene glycol, formaldehyde, nitrosamines, and other carcinogenic substances. E-cigarette and conventional cigarettes smoke could affect increasing of tracheal goblet cells and left ventricular necrosis of rat.
STATUS RESISTENSI Aedes aegypti TERHADAP MALATHION 0,8% DI KELURAHAN LABUH BARU TIMUR KECAMATAN PAYUNG SEKAKI KOTA PEKANBARU
Authors: Susanty Elva
Published: January 2024

Malathion merupakan salah satu jenis insektisida yang telah lama digunakan dalam pemberantasan vektor Demam Berdarah Dengue (DBD) yaitu Aedes aegypti (Ae.aegypti) Pemakaian insektisida dalam jangka waktu lama dapat menimbulkan efek samping seperti resistensi. Tujuan penelitian adalah untuk mengetahui status resistensi A.aegypti terhadap malathion 0,8% di Kelurahan Labuh Baru Timur.  Penelitian ini merupakan penelitian observasional deskriptif dengan desain cross-sectional. Larva Ae.aegypti diambil dari 4 RW di Kelurahan Labuh Baru Timur, kemudian dibawa ke laboratorium Parasitologi Fakultas Kedokteran Universitas Riau untuk dipelihara menjadi nyamuk dewasa. Metode uji resistensi yang digunakan adalah metode susceptibility test WHO dengan impregnated paper malathion 0,8%. Nyamuk dipindahkan tabung paparan yang sudah diberi malathion 0,8% dan tabung kontrol masing-masing sebanyak 25 ekor kemudian diamati selama 1 jam untuk melihat nyamuk knockdown. Selanjutnya nyamuk Ae.aegypti dipindahkan ke holding tube, diletakkan pada ruangan selama 24 jam kemudian dihitung mortalitas nyamuk. Hasil penelitian ini menunjukkan mortalitas  nyamuk Ae.aegypti 24 jam setelah paparn malathion 0,8% adalah 10%. Pemakaian insektisida dalam jangka waktu lama tidak efektif untuk mengeliminasi vektor demam berdarah karena dapat menimbulkan resistensi. Status resistensi nyamuk A.aegypti di Kelurahan Labuh Baru Timur terhadap malathion 0,8% adalah resisten. Perlu adanya rotasi pemakaian malathion dalam pengendalian Ae.aegyptisebagai vektor DBD.

 

Kata kunci :  malathion, resistensi, susceptibility test WHO
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BUNGA KAMBOJA PUTIH (Plumeria alba) TERHADAP Streptococcus pyogenes
Authors: Mardaningrat Kadek Herdana Vildan , Aman IGM , Jawi I Made , Indrayani Agung Wiwiek
Published: January 2024

ABSTRAK

 

Streptococcus pyogenes merupakan bakteri gram positif berbentuk kokus yang sering menyebabkan infeksi pada saluran pernapasan manusia. Pertumbuhan Streptococcus pyogenes dapat dihambat oleh senyawa fitokimia yang berasal dari bahan alam seperti bunga kamboja putih (Plumeria alba). Ekstrak etanol bunga kamboja putih telah diketahui memiliki berbagai jenis senyawa fitokimia yang dapat berperan sebagai agen antibakteri. Tujuan dari penelitian ini adalah untuk menganalisis daya hambat ekstrak bunga kamboja putih pada konsentrasi 25%, 50%, 75%, dan 100% terhadap bakteri Streptococcus pyogenes. Penelitian in vitro ini menggunakan metode true experimental post-test only control group. Sampel penelitian dibagi menjadi enam kelompok, yaitu dua kelompok kontrol terdiri dari kontrol positif yang diberikan klindamisin dan kontrol negatif yang diberikan aquades, serta empat kelompok perlakuan yaitu konsentrasi 25%, 50%, 75%, dan 100%. Metode difusi agar (Kirby-bauer) digunakan sebagai uji antibakteri. Data hasil penelitian dianalisis menggunakan software SPSS. Hasil penelitian menunjukkan ekstrak bunga kamboja putih pada konsentrasi 25%, 50%, 75%, dan 100% mempunyai daya hambat terhadap Streptococcus pyogenes dengan diameter zona hambat sebesar 7.2 mm, 8.8 mm, 9.4 mm, dan 9.6 mm. Kontrol positif yang digunakan adalah klindamisin dengan diameter 38.8 mm. Analisis Kruskal-Wallis menunjukkan hasil 0.000 yang menandakan adanya perbedaan rata-rata luas zona hambat antar kelompok yang signifikan. Dengan demikian, ekstrak etanol bunga kamboja putih pada konsentrasi 25%, 50%, 75%, dan 100% berpotensi dalam menghambat pertumbuhan bakteri Streptococcus pyogenes.

 

Kata kunci: Uji daya hambat, ekstrak, Plumeria alba, Streptococcus pyogenes
Pengaruh Efikasi Diri Meningkatkan Program Rehabilitasi Jantung Terhadap Perilaku Kesehatan Pasien Infark Miokard Di Aceh
Authors: Ahyana Ahyana
Published: January 2024

Perilaku kesehatan merupakan komponen penting dalam mencegah kekambuhan dan menurunkan angka kematian dan kecacatan secara keseluruhan setelah kejadian infark miokard (MI). Studi kuasi-eksperimental ini bertujuan untuk menguji pengaruh efikasi diri meningkatkan program rehabilitasi jantung terhadap perilaku kesehatan pada pasien dengan MI. Enam puluh empat pasien dengan MI dipilih ke dalam kelompok kontrol yang menerima perawatan standar atau kelompok eksperimen yang menerima perawatan standar dan program efikasi diri meningkatkan rehabilitasi jantung. Data pre-test dan two-time points post-test dikumpulkan menggunakan Myocardial Infarction Health Behaviors Questionnaire (MIHBQ). Uji-t berpasangan digunakan untuk menilai skor perilaku kesehatan dalam perbandingan kelompok, sedangkan uji-t independen digunakan untuk menentukan perbedaan skor perilaku kesehatan antara kedua kelompok. Hasil penelitian menunjukkan bahwa perilaku kesehatan pasien setelah menerima efikasi diri meningkatkan program rehabilitasi jantung lebih baik dibandingkan sebelum menerimanya (t = -13,91, df = 31, p < .01). Terdapat perilaku kesehatan yang meningkat secara signifikan dari kelompok eksperimen yang menerima efikasi diri meningkatkan program rehabilitasi jantung dibandingkan dengan kelompok kontrol yang menerima perawatan standar (t = 9,45, df = 62, p < 0,01). Studi ini memberikan bukti bahwa efikasi diri meningkatkan program rehabilitasi jantung dapat diterapkan dan efektif untuk meningkatkan perilaku kesehatan di antara pasien dengan MI
The QUALITY OF LIFE IN ADOLESCENT DURING COVID 19 PANDEMIC
Authors: Setiyawan I Made Karma , Apsari Ni Luh Sri , Saputra I Made Yullyantara , Sindhughosa Wega Upendra , Sinardja Siska Permanasari , Mayangsari Ayu Setyorini Mestika , Witarini Komang Ayu , Dewi Ida Ayu Made Ratna
Published: January 2024

Background : Assessment of quality of life in children is a useful indicator of overall health because it encompasses information about children's physical and mental health. Managing the existing environment and adhering to current constraints due to Covid-19 can be especially difficult for children and adolescents because these conditions can be regarded as incompatible with their developmental tasks. The Pediatric Quality of Life Inventory (PedsQL) is a tool designed to assess children's quality of life based on age, maturity, and cognitive development. While self-report is the gold standard for measuring perceived PedsQL, there may be occasions when the kid is too young, too sick, or too tired to complete PedsQL instrument, in which case a parent-proxy report may be required.

Methods : An analytic observational study using a cross-sectional design involve three elementary schools in the Jimbaran area, Badung, Bali. The research was conducted at Udayana University Hospital in July 2022. Detailed explanations about the context and how to fill out the PedsQL form were given to students and their parents. The students and parents fill out PedsQL forms in separate rooms. The PedsQL questionnaire used was the Indonesian version. Concordance between self-report and parent-proxy was evaluated using the Wilcoxon paired sign rank test. Intraclass correlation coefficients (ICC) to assess parent and child agreement.

Results : Amongst 189 children, median age was 11 years (range 11–13 years). There was no difference in PedsQL between self-report and parent-proxy in overall and subscales functioning domain. Physical, emotional, social, and school functioning all had intraclass correlation coefficients of 0.85, 0.83, 0.79, and 0.88, respectively. Low energy (physical functioning), feel afraid or scared and feel angry (emotional functioning), and can’t do things that children his age do (social functioning) were found different among factor loadings. School functioning factor loadings were found similar.

Conclusion : This study shows a good agreement and no significant difference in overall and subscale scores between children's self-report and parent-proxy reports. Although significant differences were found when examining each factor loadings in each component.
Formulasi Emulgel Antiinflamasi Ekstrak Kulit Batang Jambu Mete (Anacardium occidentale L.)
Authors: DAUD NUR SAADAH , Angraeni Ni Kadek Ayu , . Karmilah , Fauziah Yulianti
Published: January 2024

Inflamasi merupakan suatu respons protektif normal terhadap luka jaringan yang disebabkan oleh trauma fisik, zat kimia yang merusak atau zat-zat mikrobiologik. Salah satu tanaman yang dapat digunakan sebagai antiinflamasi yang berasal dari alam adalah  jambu mete (Anacardium occidentale L.). Kulit batang jambu mete mengandung senyawa fenolik menghambat  inflamasi  dengan  mekanisme  penangkapan  radikal  bebas  dan  menghambat enzim  siklooksigenase. Ekstrak kulit batang jambu mete dapat diformulasi menjadi sediaan emulgel untuk memudahkan pemanfaatannya sebagai antiinflamasi topikal. Carbomer 980 0,5% digunakan sebagai gelling agent dengan beberapa varian konsentrasi ekstrak yaitu 2,5 % (Formula A), 5 % (Formula B) dan 7,5 % (Formula C). Bahan tambahan lain terdiri atas parafin cair, span 80, tween 80, propilenglikol, nipagin, nipasol, trietanolamin dan akuades. Evaluasi fisik sediaan dilakukan setiap 3 hari sekali sebanyak 4 kali pengujian. Hasil evaluasi fisik menunjukkan ketiga formula menghasilkan sediaan berbentuk massa emulgel yang berwarna coklat muda, bau khas, homogen, rata-rata pH 5,0 dan daya sebar berkisar antara 5,15 - 5,56 cm. Sedangkan hasil uji stabilitas, formula A dengan konsentrasi ekstrak 2,5 % adalah yang paling stabil setelah dilakukan uji sentrifugasi dan cycling test.
PREVALENSI NYERI PERGELANGAN TANGAN PADA SISWA PENGENDARA SEPEDA MOTOR DI SMA NEGERI 11 DENPASAR TAHUN 2022
Authors: Sengga Agnes Simona , Muliani Muliani , Yuliana Yuliana , Karmaya I Nyoman Mangku
Published: January 2024

Nyeri pergelangan tangan memiliki prevalensi yang cukup tinggi baik di Indonesia maupun luar negeri. Nyeri pergelangan tangan dapat disebabkan oleh penyebab traumatis dan non traumatis. Nyeri pergelangan tangan yang disebabkan oleh trauma fisik salah satunya adalah akibat aktivitas mengendarai sepeda motor yang turut dialami pula pada siswa sekolah menengah atas. Penelitian ini dilakukan untuk mengetahui prevalensi nyeri pergelangan tangan pada siswa pengendara sepeda motor di SMA Negeri 11 Denpasar tahun 2022. Penelitian ini menggunakan desain potong lintang deskriptif. Metode pengambilan sampling adalah purposive sampling. Subyek penelitian adalah 315 siswa SMA Negeri 11 Denpasar yang memenuhi kriteria inklusi yaitu siswa yang mengendarai sepeda motor dan bersedia menjadi subyek penelitian serta kriteria eksklusi berupa siswa yang mengalami infeksi atau trauma serta pernah dilakukan operasi pada pergelangan tangannya. Data primer diambil dari kuesioner dan pengukuran langsung oleh peneliti. Berdasarkan hasil penelitian, prevalensi nyeri pergelangan tangan pada siswa pengendara sepeda motor di SMA Negeri 11 Denpasar pada tahun 2022 adalah 33,0%. Berdasarkan faktor risiko yaitu lama pengalaman berkendara, durasi berkendara per hari, jarak berkendara per hari, indeks massa tubuh, dan jenis kelamin, proporsi nyeri pergelangan tangan lebih banyak terjadi pada siswa yang mengendarai sepeda motor lebih dari 3 tahun (34,1%), siswa yang berkendara lebih dari 4 jam per hari (50,0%), siswa yang berkendara lebih dari 5 kilometer per hari (40,5%), siswa yang mengalami kekurangan berat badan tingkat berat (46,3%), dan siswa perempuan (49,0%). Diharapkan penelitian ini dapat digunakan lebih lanjut untuk meneliti hubungan antar faktor risiko.

Kata kunci :  prevalensi, nyeri pergelangan tangan, pengendara sepeda motor, siswa SMA
Characteristics of Tension-Type Headache among Nurse in Udayana University Hospital
Authors: Savitri Ni Putu Sista Ijya , Wijayanti Ida Ayu Sri , Widyastuti Ketut , Indrayani Ida Ayu Sri
Published: January 2024

Background: Headache is the most common complaint experienced by people in the world with the highest prevalence spesifically tension-type headache. Nurses are one of the professions with the risk of experiencing tension-type headache that can affect performance, costs, and work results. The purpose of this study was to determine the prevalence and characteristics of tension-type headache among nurses who work in the hospital. Method: This research is a cross-sectional descriptive study with consequtive sampling technique involving 89 nurses at Udayana University Hospital using primary data obtained from questionnaires (google form) and then analyzed by using SPSS 26. Results: The results showed that the prevalence of tension-type headache in nurses was 46.1%. Based on the most common characteristic in nurses, spesifically within the age of 26-35 years about 80.5%, female gender about 65.9%, obesity category about 39%, no stress category about 95.1%, sleep duration > 6 hours about 58.5%, shift nurses about 92.7%, nurses in inpatient room about 70,7%, and below 3 years duration of work about 80.5%. Conclusion: The prevalence of tension-type headache in nurses is 46.1% with the most characteristics at the age of 26-35 years (early adulthood), female gender, dominated by obesity category, no stress category, sleep duration > 6 hours, dominant in shift nurses, mostly in inpatient room nurses and below 3 years duration of work.

Keywords: Tension-type headache, characteristics, nurse
Tatalaksana Awal Pasien Gagal Jantung Akut Akibat Penyakit Jantung Koroner di Ruang Emergency Pelayanan Jantung Terpadu Rumah Sakit Umum Pusat Sanglah
Authors: Cahya Ningrum Ni Komang Sri Adelia , Suastika Luh Oliva Saraswati , Swi Antara I Made Putra , Wita I Wayan
Published: January 2024

ABSTRACT

               Acute heart failure is a clinical syndrome with a complex of symptoms that is typical shortness of breath at rest or during activity. Acute heart failure is mostly caused by coronary heart disease. Coronary heart disease is a heart failure disease with narrowed coronary arteries can be caused by the buildup of a layer of fat on the walls of the coronary arteries. The purpose of this study was to determine the initial management of patients with acute heart failure due to coronary heart disease in the Integrated Heart Service Emergency Room, Sanglah Hospital. This study is a descriptive study using a cross sectional research method on a sample of 43 people who came to the PJT Emergency Room at Sanglah Hospital with a diagnosis of acute heart failure due to coronary heart disease in 2019-2020. The data that has been obtained were then analyzed using SPSS version 24. The results showed that most of the patients 30 sample (69.77%) were male compared to women, there were 13 sample (30.23%). The majority of patients with acute heart failure due to coronary heart disease come to the Emergency Room with complaints of shortness of breath. Initial treatment given in the Emergency Room included intravenous diuretic Furosemide with a dose range of 20-80 mg/IV (93.02%), Beta blockers (2.35%), Nitroglycerin (13.95%), Digoxin (13.95%), and Dobutamine (30.23%). Most of the patients in this study were given Furosemide as an initial treatment according to the PERKI 2020 guidelines which suggest the administration of Furosemide as a treatment for fluid congestion in acute heart failure. Some patients require inotropic support such as Dobutamine which is adjusted according to individual clinical criteria. Supporting examinations were carried out on all study samples (100%) including electrocardiogram (ECG) and chest X-ray examinations.

Keywords: Acute heart failure, Coronary heart disease, Initial management
PERBANDINGAN PENGARUH PEMBERIAN JUS BUAH NAGA MERAH(HYLOCEREUS POLYRHIZUS) DENGAN OBAT SIMVASTATIN TERHADAP PENURUNAN KADAR KOLESTEROL DARAH MENCIT (MUS MUSCULUS) DENGAN KONDISI HIPERKOLESTEROLEMIA
Authors: Nabasa Gayus Erino , Jawi I Made , Satriyasa Bagus Komang
Published: January 2024

This study aims to determine the effect of giving red dragon fruit juice with graded doses on reducing total cholesterol levels of mice with hypercholesterolemic conditions. This research was conducted to prove the anti-cholesterol effect of red dragon fruit juice with a dose variation of 0.39 gr / 30grBB 0.65 gr / 30grBB and 0.91 gr / 30grBB in Swiss male mice with high cholesterol conditions. The subjects of this study were 30 Swiss mice which were divided randomly into 5 groups. This study was an experimental study with a pre-test and post-test control group design. Group 1 as a negative control (high cholesterol diet), group 2 as a positive control. (high cholesterol diet and simvastatin drug), and group 3 (high cholesterol diet and red dragon fruit juice 0.39 gr / 30grBB), group 4 (high cholesterol diet and red dragon fruit juice 0.65 gr / 30grBB), group 5 (high cholesterol diet and red dragon fruit juice 0.91 gr / 30grBB).The parameters measured were the total cholesterol level of mice using the easy touch GCU tool. The data of the results of the study were analyzed by one way ANOVA test with a significance level of ? = 5% with multiple comparisons (Post Hoc Test) LSD type. The results of the study with various doses showed a decrease in total cholesterol levels by 10%; 11%; 15%. The dose variation in this study gave the best results to reduce total cholesterol levels, namely at a dose of 0.91 gr / 30grBB.Based on the result of the study, shows that he administration of red dragon fruit juice showed a significant difference in total cholesterol blood levels of mice.

Keywords : Red dragon fruit juice , Cholesterol , Antosianin , Total cholesterol
IDENTIFIKASI SUBTIPE Enterotoxigenic Escherichia coli DAN Enteroaggregative Escherichia coli PADA BIJI KOPI FESES LUWAK (Paradoxorus hermaphroditus) DARI BEBERAPA AGROWISATA DI BALI
Authors: Wira Guna I Gede Bhima , Budayanti Ni Nyoman Sri , Hendrayana Made Agus , Sukrama I Dewa Made
Published: January 2024

ABSTRAK

Latar Belakang: Kopi luwak merupakan salah satu kopi yang terkenal akan citra rasanya. Indonesia merupakan salah satu penghasil kopi luwak terbaik di dunia, Bali merupakan salah satu tempat yang banyak memproduksi  kopi luwak. Kopi luwak berasal dari hasil pencernaan hewan luwak yang memakan biji kopi. Luwak merupakan hewan berdarah panas yang didalam sistem pencernaannya terdapat banyak bakteri flora nomal, yaitu Escherichia coli. Pada proses pengolahan dari biji kopi feses luwak masih banyak dilakukan secara tradisional, hal tersebut membuat petani luwak yang mengolah berpeluang tercemar bakteri Escherichia coli sehingga dapat menyebabkan diare. Penelitian ini bertujuan untuk mengdentifikasi adanya bakteri Escherichia coli subtipe Enterotoxigenic Escherichia coli (ETEC) dan Enteroaggergative Escherichia coli (EAEC) pada biji kopi feses luwak dari beberapa agrowisata di Bali. Metode: Penelitian ini adalah penelitian deskriptif dengan rancangan penelitian observasional. Penelitian ini menggunakan sebanyak 18 sampel yang diambil pada agrowisata di setiap kabupaten dan kota di Bali. Seluruh sampel diperiksa di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Udayana. Sampel tersebut dikultur pada media Eosin Methylen Blue Agar (EMBA) dan hasil murni bakteri Escherichia coli dilanjutkan uji konfrontasi menggunakan pengecatan gram, serta tahap identifikasi subtipe ETEC dan EAEC dengan menggunakan metode Polymerase Chain Reaction (PCR). Hasil: Dari 18 sampel yang dikumpulkan, 13 (72%) sampel positif bakteri Escherichia coli. 13 sampel positif dilanjutkan ke proses PCR dan didapatkan tidak terdeteksi adanya subtipe ETEC dan EAEC. Simpulan: Pada penelitian ini ditemukan bakteri Escherichia coli pada Sebagian besar sampel biji kopi feses luwak yaitu 72%. Namun setelah diidentidikasi lebih lanjut pada metode PCR, tidak adanya subtipe ETEC dan EAEC pada seluruh sampel positif Escherichia coli.

Kata Kunci : Biji kopi feses luwak, Escherichia coli, Diare
KARAKTERISTIK PASIEN SIROSIS HEPATIS DI RSUD Dr. H. CHASAN BOESOIRIE TERNATE
Authors: Zulhadji Fadilah Megalisa
Published: January 2024

Latar Belakang. Sirosis hepatis adalah akibat paling sering dari perjalanan klinis yang lama dari semua penyakit hati kronis yang ditandai dengan rusaknya parenkim hati. Sirosis hepatis menempati urutan ke-7 penyebab kematian di dunia. Maluku Utara sendiri belum ada data khusus yang menggambarkan karakteristik sirosis hepatis. Tujuan. Untuk mengetahui karakteristik pasien sirosis hepatis di RSUD Dr. H. Chasan Boesoirie Ternate tahun 2017-2021. Metode. Desain penelitian yang digunakan yaitu penelitian deskriptif observasional. Hasil. pasien sirosis hepatis paling banyak terjadi pada kelompok usia lansia akhir (56-65 tahun) sebanyak 11 kasus (47.8%) dan lebih sering pada laki-laki sebanyak 15 kasus (65.2%). Dari pekerjaan yang dikelompokan peneliti, pegawai mempunyai angka persentase yang lebih tinggi dibanding wiraswasta dan tidak bekerja yaitu kelompok pegawai sebanyak 7 kasus (30.4%), terdapat juga kategori lainnya (ibu rumah tangga dan swasta) sebanyak 11 kasus (47.8%). Pasien sirosis hepatis memiliki nilai kreatinin terbanyak 0,7-1,3 (normal) sebanyak 15 kasus (65%), jumlah trombosit paling banyak <150.000 yaitu sebanyak 13 kasus (57%), dan kadar albumin tertinggi pada kategori <3,0 sebanyak 19 kasus (83%). Untuk etiologi paling banyak yaitu hepatitis B sebanyak 13 kasus (57%). Simpulan. Usia lansia akhir (56-65 tahun), pekerjaan pada kategori lainnya termasuk ibu rumah tangga dan swasta, serta nilai kreatinin normal, penurunan trombosit (trombositosis), kadar albumin menurun, dan etiologi hepatitis B adalah karakteristik pasien sirosis hepatis di RSUD Dr. H. Chasan Boesoirie Ternate tahun 2017-2021.

Kata kunci: Sirosis Hepatis., Karakteristik., Ternate
GAMBARAN AUDIOMETRI NADA MURNI PASIEN PRESBIKUSIS DI POLI THT-KL RSUP SANGLAH DENPASAR
Authors: Darma Putra I Gusti Ngurah Agung
Published: January 2024

Abstrak

Latar Belakang: Presbikusis merupakan penyakit neurodegeneratif terbanyak dan gangguan komunikasi nomor satu di dunia. Etiologi presbikusis belum diketahui namun terdapat beberapa faktor yang dapat mempengaruhi terjadinya presbikusis seperti usia, jenis kelamin, hipertensi serta diabetes melitus. Presbikusis menjadi perhatian program penanggulangan gangguan pendengaran dan ketulian dengan tujuan untuk menurunkan angka kejadian presbikusis sebesar 90% pada tahun 2030. Sehingga penulis tertarik untuk meneliti gambaran audiometri nada murni pasien presbikusis di poli THT-KL RSUP Sanglah Denpasar.

Metode: Penelitian ini merupakan penelitian desktiptif potong lintang dengan mengambil data sekunder dari rekam medis pasien yang terdiagnosa presbikusis. Sampel diambil dengan tehnik total sampling dan diperoleh sebanyak 65 sampel.

Hasil: Berdasarkan kelompok usia, mayoritas berada pada usia 60-70 tahun yaitu 36 sampel (55,39%), dengan jenis kelamin terbanyak adalah laki-laki yaitu 51 sampel (78.5%). Berdasarkan derajat gangguan pendengaran, didapatkan mayoritas derajat sedang pada telinga kanan yaitu 29 sampel (44,61%) dan derajat sedang pada telinga kiri yaitu 27 sampel (41,54%). Berdasarkan usia, derajat pendengaran pada usia 60-70 tahun didapatkan hasil mayoritas derajat ringan dan derajat sedang sebanyak 14 sampel (21,54%), pada usia 71-80 tahun didapatkan mayoritas derajat sedang sebanyak 14 sampel (21,54%), dan pada usia >80 tahun didapatkan mayoritas derajat sedang dan derajat berat sebanyak 1 sampel (1,54%). Berdasarkan tipe audiometri, hasil terbanyak berupa tipe strial yaitu 25 sampel (38,5%).

Simpulan: Pada penelitian ini kelompok usia terbanyak adalah usia 60-70 tahun, dengan mayoritas laki-laki. Derajat pendengaran pasien terbanyak yaitu derajat sedang dengan tipe audiometri terbanyak adalah tipe strial.

Kata Kunci : Presbikusis, audiometri, strial
INCREASED TNF-? mRNA EXPRESSION IN PBMC CELLS INFECTED WITH HEPATITIS B VIRUS EXPOSED TO PURPLE SWEET POTATO EXTRACT (Ipomoea batatas L.)
Authors: Hendrayana Made Agus
Published: January 2024

Hepatitis B Virus infection is a serious health problem throughout the world that can cause death. Purple sweet potatoes contain quite high levels of anthocyanins. Anthocyanins have been widely proven to act as immunostimulators by influencing levels of the cytokine TNF-?. This study aims to prove that purple sweet potato extract has an effect on TNF-? mRNA expression in PBMC cell cultures infected with the hepatitis B virus. The research sample was a PBMC cell culture taken from an asymptomatic chronic Hepatitis B patient. The samples from the normal saline control group were 18 wells and the treatment group with purple sweet potato extract with an anthocyanin content of 0.265 mg/100g was 18 wells. Purple sweet potato extract is made using the maceration technique. PBMCs were isolated from blood using Ficoll-Paque. PBMC cells were cultured in 24 well plates with complete RPMI 1640 medium. Examination of TNF-? mRNA expression using Relative 1-step qRT-PCR quantification. The results showed the mean difference in TNF-? mRNA expression between the treatment and control groups: 20.08 fg/µL (p<0.05), there was a significant increase in TNF-? mRNA expression. The results of this study can be concluded that administration of purple sweet potato extract  in vitro can increase TNF-? mRNA expression in PBMC cultures infected with hepatitis B virus.
CRIAÇÃO DE MODELO DE RISCO A INUNDAÇÃO PARA A BACIA HIDROGRAFICA DO RIO JACUÍPE (AL/PE) A PARTIR DO MÉTODO DE PROCESSO ANALÍTICO HIERÁRQUICO – AHP
Authors: De Lima Ana Carolina Cavalcante , Faccioli Gregorio Guirada , Medeiros Fabiana Carnaúba
Published: January 2024

RESUMO
Objetivo: Identificar e avaliar as áreas suscetíveis a ocorrências de inundação na bacia hidrográfica do Rio Jacuípe através do modelo de reclassificação de variáveis e o método AHP aliado ao ambiente SIG.
Referencial teórico: Este estudo foi elaborado a partir da revisão teórica sobre temas de riscos ambientas, onde as principais causas apontadas para favorecer o fenômeno de inundação incluem características do solo, padrões de uso e ocupação do solo, e elementos geomorfológicos como a hipsometria e declividade.
Método: Fundamenta-se no processo analítico hierárquico dos fatores ambientais, no levantamento de dados por meio de técnicas de geoprocessamento e observações em campo. As informações foram adquiridas através do Projeto de Mapeamento Anual do Uso e Cobertura da Terra no Brasil (MapBiomas), Empresa Brasileira de Agropecuária (Embrapa) e United States Geological Survey (USGS).
Resultados e conclusão: Os resultados indicam altíssimos riscos na bacia hidrográfica em regiões às margens dos corpos d'água, caracterizadas por relevo plano, baixas altitudes e declividade menores. Grande parte dessas localidades estão suscetíveis a inundações em caso de cheias no rio principal.
Implicações da pesquisa: A criação do modelo de risco a inundação pode representar grande valor socioeconômico e ambiental para os municípios, servindo de base para auxiliar gestores na adoção de medidas estruturais e emergências na redução riscos hidrológicos.
Originalidade/valor: Esta pesquisa é inovadora na bacia hidrográfica do Rio Jacuípe, possui relevância cientifica pela originalidade na representação e abordagem dos dados e pelas discussões apresentadas.
Palavras-chave: Riscos Ambientais, Modelo de Reclassificação de Variáveis, Geoprocessamento.
The Effect Of Corporate Culture On Sustainability Report Quality
Authors: Atika Atika , Simamora Alex Johanes
Published: January 2024

This research aims to examine the effect of corporate culture on sustainability report quality. The total research samples are 68 observations on the index of Sri Kehati. Corporate culture includes cultures of clan, adhocracy, hierarchy, and market. Sustainability report quality is measured by the scoring method. Data analysis uses regression tests. Based on data analysis, low clan culture, high hierarchy culture, and high market culture lead to high sustainability report quality. However, there is no effect of adhocracy culture on sustainability report quality. This research contributes to investigating how far the implementation of POJK no. 51/POJK.03/2017 can lead firms to have high-quality sustainability reports. This research also contributes to providing evidence in emerging countries such as Indonesia.
Corporate Reputation, Available Slack, And Financial Distress Risk
Authors: Aminatuzzuhro  , Indrawati Trisa , Fitriani Nurul
Published: January 2024

The global COVID-19 pandemic and the associated economic recession have posed significant challenges for companies in Indonesia. Many companies have struggled to survive, leading to mass layoffs or bankruptcy. This study is motivated to research the financial factors (namely, company reputation and available slack) related to the risk of financial difficulties, using 1,699 observations from non-financial public companies in Indonesia from 2020 to 2022. The research was conducted using moderated regression analysis performed with STATA software. The research results indicate that company reputation is negatively related to the risk of financial difficulties, and available slack strengthens this relationship. These results were robustly tested using coarsened exact matching. This study provides information for companies and stakeholders on reducing the risk of financial difficulties by strengthening the company's reputation and available slack.
The Role Of Gender Diversity In Increasing ESG Performance Through Intellectual Capital
Authors: Isnindiah Sofiati  , Aria Farah Mita
Published: January 2024

This study examines whether intellectual capital mediates the association between board gender diversity and ESG performance. The samples were selected based on criteria that included all non-financial companies registered on the Indonesia Stock Exchange. The total observations are 257 in the period 2017 to 2022. ESG scores were obtained from the Refinitiv Eikon database as a proxy for ESG performance, intellectual capital proxied by the value-added intellectual coefficient (VAIC) model, and directors' gender diversity proxied by the percentage of female directors. The results show intellectual capital mediates the association between board gender diversity and ESG performance. These results suggest that board gender diversity positively affects ESG performance if the company has intellectual capital that adds value to create competitiveness. This study aims to help companies understand the importance of gender diversity in managing and utilising intellectual capital to improve the company's ESG performance.
Palliative extubation: an experience of four cases in a neonatal intensive care unit
Authors: Guerreiro Beatriz , Leite Fernanda , Prette Iasmin , Venturin Jaqueline , Dias Daneila
Published: January 2024

OBJECTIVE: Characterize and describe neonatal patients with severe and irreversible conditions undergoing palliative extubation in a neonatal intensive care unit . CASE DESCRIPTION: Descriptive analysis of four cases of palliative extubation in a neonatal intensive care unit of a childrens hospital in the year 2019 to 2020 based on a review of electronic medical records of the following data: age, primary diagnosis, period of intubation, time of life between extubation and death, symptoms described in the time interval between extubation and death and comfort measures taken, family approach, diagnosis and previous or not follow-up with the palliative care team. All diseases into the exclusive palliative care classification. All patients died after the palliative extubation. The approach of the palliative care team was based on providing comfort measures for the patient, support for the family and the staff of the neonatal intensive care unit. CONCLUSION: The need for knowledge and deepening of the practice of palliative extubation is essential to make the end of life a time free of suffering, valuing respect and dignity for patients.
PENGARUH TINGKAT PENGANGGURAN, INFLASI, DAN PERTUMBUHAN EKONOMI TERHADAP KEMISKINAN DI NTT
Authors: Mangi Arya Umbu Djuma Mone , Marseto Marseto
Published: January 2024

AbstrakKemiskinan merujuk pada kondisi individu atau kelompok yang tidak dapat untuk memenuhi kebutuhan ekonominya yang mana kebutuhan tersebut merupakan kebutuhan pokok yang seharusnya dapat terpenuhi. Kemiskinan sering diartikan sebagai kondisi dengan kekurangan uang serta barang yang akan dipergunakan untuk memenuhi kelangsungan hidupnya. Tujuan dilaksanakannya penelitian penelitian ini ialah guna mengetahui pengaruh tingkat pengangguran, inflasi, dan pertumbuhan ekonomi terhadap kemiskinan di Nusa Tengga Timur. Metode penelitian yang dipergunakan ialah dengan analisis regresi linier berganda. Dilakukannya penelitian ini diperoleh kesimpulan jika secara simultan terdapat adanya pengaruh yang singnifikan antara Tingkat Pengangguran, Inflasi, dan Pertumbuhan Ekonomi terhadap Kemiskinan di Nusa Tenggara Timur. Sebaliknya, secara parsial Tingkat Pengangguran memiliki pengaruh yang signifikan dan positif, Inflasi mempunyai pengaruh yang tidak signifikan dan positif, sedangkan Pertumbuhan Ekonomi berpengaruh signifikan dan negatif terhadap Kemiskinan di Nusa Tenggara Timur.Kata Kunci : Kemiskinan; Tingkat Pengangguran; Inflasi; Pertumbuhan Ekonomi AbstractPoverty refers to the condition of individuals or groups who are unable to meet their economic needs where these needs are basic needs that should be fulfilled. Poverty is often interpreted as a condition with a lack of money or goods that will be used to fulfill their survival. The purpose of carrying out this research research is to determine the effect of the unemployment rate, inflation, and economic growth on poverty in East Nusa Tengga. The research method used is multiple linear regression analysis. The conclusion of this research is that simultaneously there is a significant influence between the Unemployment Rate, Inflation, and Economic Growth on Poverty in East Nusa Tenggara. Conversely, partially the unemployment rate has a significant and positive effect, inflation has a non-significant and positive effect, while economic growth has a significant and negative effect on poverty in East Nusa Tenggara.Keywords : Poverty; Unemployment Rate; Inflation; Economic Growth
Diferentes tipos de acesso para pacientes em hemodiálise, aspectos positivos e negativos
Authors: Araújo Lívia Fagundes dos Anjos , Pereira Cecília Iucif , Mendes Mariane Fortunato , Filgueiras Isabel Leite , Pinto Laura Carrara de Magalhães , Carvalho Gabriela Mésseder de , Diláscio Fernanda Kato , Araújo Henrique Fagundes dos Anjos , Araújo Rafael Fagundes dos Anjos , Cerqueira Débora da Cruz
Published: January 2024

Objetivo: Identificar na literatura médica evidências positivas e negativas dos acessos disponíveis para hemodiálise. Revisão bibliográfica: Quanto à escolha do Cateter de Curta Permanência (CCP), verifica-se adequada em pacientes necessitados de hemodiálise imediata. Contudo, deve ser substituído por PermCath ou Fístula Arteriovenosa (FAV) quando possível, pois ele apresenta o maior risco de infecção primária da corrente sanguínea em casos de permanência estendida. Sobre o Cateter de Longa Permanência (CLP), observa-se coerência quando usado em pacientes que aguardam ou que não possuem vasos prévios para a realização da FAV, entretanto, o CLP apresenta riscos consideráveis de infecção. Sobre a realização da FAV, evidencia-se maior segurança e durabilidade, além de um menor risco de infecções, embora seu uso precoce promova a possibilidade de falha e demande múltiplas intervenções. Considerações finais: Ainda que a FAV seja a opção de menor risco de infecções em comparação com os catéteres tradicional e de longa permanência, conclui-se que é importante a análise individual e personalizada para oferecer o tratamento ideal para o momento do paciente, considerando seu estado de saúde e comorbidades presentes.
PERAN GURU DALAM MEMBENTUK GREEN BEHAVIOUR PESERTA DIDIK DI SMP EL-FITRA KOTA BANDUNG
Authors: Abdul Kholik Nasrul
Published: January 2024

Penelitian ini dilatar belakangi oleh kecenderungan manusia berbuat semena-mena terhadap lingkungan, sering sekali manusia sebagai ‘penguasa’ bumi tidak bertanggung jawab terhadap lingkungan yang ditempatinya, dengan itu kesadaran terhadap pentingnya tanggung jawab terhadap lingkungan harus ditanamkan. Sekolah menjadi tempat strategis untuk membangun kesadaran tersebut, dan guru adalah peran utama dalam pembentukan karakter tersebut yang dalam penelitian ini adalah karakter green behaviour. Tujuan dari penelitian ini adalah untuk mengetahui peran guru dalam membentuk green behaviour peserta didik baik secara kognitif, afektif maupun psikomotorik. Jenis penelitian yang digunakan adalah penelitian deskriptif kualitatif dan yang menjadi subjek dari penelitian ini adalah seluruh guru IPS di SMP El-Fitra. Penentuan subjek dalam penelitian ini adalah kepala sekolah, peserta didik dan wakil kepala sekolah bagian kurikulum di SMP El-Fitra Kota Bandung. Hasil dari penelitian ini yaitu peran guru sebagai mengajar dan mendidik, bimbingan, memerikan arahan, serta memberikan teladan pada peserta didik dalam pembentukan green behaviour. Untuk pelaksanaan green behaviour di SMP El-Fitra, dengan mengadakan fasilitas dan pemenuhan kebutuhan terhadap program green behaviour, seperti pengadaan tempat sampah dan menyediakan makanan dan minum untuk isi ulang. Sehingga meminimalisir penambahan sampah dan untuk menjaga kebersiahannya ada penerapan program class competition. Sementara perilaku siswa mengenai green behaviour di SMP El-fitra sudah mencerminakan, seperti siswa terbiasa membawa tempat makan sendiri, menjaga kebersihan diri dan menjaga lingkungan sekitar.Kata kunci: Peran guru, green behaviour, lingkungan
Physical, Nutritional, and Chemical Profile of Innovative Bakery Products
Authors:   Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal, LA Pascoalino , M Ayuso ,   Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal, E Pereira ,   Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal, E Ferreira ,   Pão de Gimonde®, M Ferreira & Filhas, LDA, EN218, n° 3798, 5300-553, Gimonde, Portugal, ICFR Ferreira ,   Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal, L Barros ,   Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Published: January 2024

Bakery products are the most eaten up foods worldwide. Among them, bread is regular consumed, due to their composition in macro and micronutrients. Nevertheless, the refined wheat used in traditional baking reduces its nutritional quality, causing some health problems related to obesity and diabetes. In this study, a comparative analysis among five non-conventional bread supplemented with different grains (rye (RB), Chickpea Flour (CFB), Multi-Seed (MSB), Biological Spelt (BSB), Chickpea and Wheat Sprouted Brains (CWSB)) was performed. Their physical profile (texture, colour and pH), centesimal composition, free sugars, and fatty acids was evaluated. Regarding the nutritional profile, MSB and BSB showed a high protein concentration. The highest concentration of PUFA and lowest SFA was registered for the BSB and MSB, respectively. CWSB revealed the highest concentration of soluble sugars. This study demonstrates that partially replacing wheat flour for bread baking is an alternative to improve their nutritional quality.
Cation Effects on the Acidic Oxygen Reduction Reaction at Carbon Surfaces
Authors: Hübner Jessica , Lucchetti Lanna , Nong-Reier Hong Nhan , Sharapa Dmitry I. , Paul Benjamin , Kroschel Matthias , Kang Jiaqi , Teschner Detre , Behrens Silke , Studt Felix , Knop-Gericke Axel , Siahrostami Samira , Strasser Peter
Published: January 2024

Hydrogen peroxide (H2O2) is a widely used green oxidant. Until now, research focused on the development of efficient catalysts for the two-electron oxygen reduction reaction (2e– ORR). However, electrolyte effects on the 2e– ORR have remained little understood. We report a significant effect of alkali metal cations (AMCs) on carbons in acidic environments. The presence of AMCs at a glassy carbon electrode shifts the half wave potential from -0.48 to - 0.22 VRHE. This cationic induced enhancement effect exhibits a uniquely sensitive on/off switching behaviour depending on the voltammetric protocol. Voltammetric and in situ X-ray photoemission spectroscopic evidence is presented, supporting a controlling role of the potential of zero charge of the catalytic enhancement. Density functional theory calculations associate the enhancement with the stabilization of the *OOH key intermediate as a result of locally induced field effects from the AMCs. Finally, we developed a refined reaction mechanism for the H2O2 production in presence of AMCs.
Nitrogen-to-Carbon Single Atom Point Mutation of Pyridine N-Oxides
Authors: Falcone Nicholas , He Sam , Hoskin John , Mangat Sandeep , Sorensen Erik
Published: January 2024

Single-atom editing has emerged as a powerful process for altering molecular structures with precision. Within this growing class of transformations, reactions that replace one atom for another in heterocycles, while desirable, remain limited. We report the development of a transformation that achieves an N-to-C atom swap in pyridine N-oxides utilizing a sulfoxide-derived anion as a carbon source. This ‘point mutation’ exhibits good functional group tolerance and replaces the N-oxide moiety with either unsubstituted, substituted, or isotopically labeled carbon atoms in a single laboratory operation.
Approaching the Complete Basis Set Limit for Transition Metal Spin–State Energetics
Authors: Drabik Gabriela , Radoń Mariusz
Published: January 2024

Convergence to the complete basis set (CBS) limit is analyzed for the problem of transition metal (TM) spin-state energetics by taking under scrutiny a benchmark set of 18 energy differences between spin states for 13 chemically diverse TM complexes. The performance of conventional CCSD(T) and explicitly correlated CCSD(T)-F12a/b calculations in approaching the CCSD(T)/CBS limits is systematically studied. An economic computational protocol is developed based on the CCSD-F12a approximation and (here proposed) modified scaling of the perturbative triples term, (T#). This computational protocol recovers relative spin–state energetics of the benchmark set in excellent agreement with the reference CCSD(T)/CBS limits (mean absolute deviation 0.4, mean signed deviation 0.2, and maximum deviation 0.8 kcal/mol) and enables performing canonical CCSD(T) calculations for mononuclear TM complexes sized up to ca. 50 atoms, which is illustrated by application to heme-related metalloporphyrins. Furthermore, a good transferability of the basis set incompleteness error (BSIE) is demonstrated for spin–state energetics calculated using CCSD(T) and other wave-function methods (MP2, CASPT2, CASPT2/CC, NEVPT2, MRCI+Q), which justifies efficient focal-point approximations and simplifies construction of multi-method benchmark studies.
Accelerated Analysis of the Electrochemical Production Route for Biomass-derived Adiponitrile
Authors: Mathison Ricardo , Rani Elina , Patel Meera K. , Bloomquist Casey K. , Lopez Cerrato Antonio , Modestino Miguel A.
Published: January 2024

Electrochemical transformation of biomass feedstocks offers a promising route for sustainable production of fuels and chemicals, enhancing integration with renewable energy sources. Adiponitrile, a key intermediate in Nylon 6,6 production, is mainly produced through thermochemical processes or methods relying fossil fuel feedstocks. Alternatively, it can be produced through Kolbe coupling of biomass-derived 3-cyanopropanoic acid, with its practical implementation hinging on understanding and controlling factors that dictate reaction selectivity. In this study, we establish relationships between electrolyte composition, electrochemical conditions, and performance metrics in this approach, achieving a maximum Faradaic efficiency of 40% towards adiponitrile at current densities up to 500 mA cm-2. Implementing a semi- autonomous high-throughput electrochemical workflow, we tested hundreds of reaction conditions, accelerating the exploration of reaction parameters. Limitations and guidelines obtained from this study apply to a range of electrochemical decarboxylation reactions, and the accelerated research approach shows potential for speeding the development of sustainable electrochemical processes.