bluuebunny/crossref_metadata_2025 huggingface dataset:
Védőoltásokkal kapcsolatos kételyek és elkötelezettség a magyarországi egészségügyi alapellátásban dolgozók körében
Authors: Kun Eszter , Benedek Angéla , Mészner Zsófia
Published: November 2019

Abstract:

Introduction: The attitude to immunization and the issue of vaccine hesitancy in health care workers (HCWs) have been studied in a former survey performed by ECDC (European Centre for Disease Prevention and Control). Aim: Our aim was to study the immunization attitude of primary care paediatricians, general practitioners and primary care nurses in Hungary. Method: We studied vaccine hesitancy in HCWs by way of a questionnaire, developed on the basis of a recent similar survey by ECDC in four countries. The online survey has been performed between May and July 2017. Altogether 765 questionnaires have been returned: 189 primary care paediatricians, 375 general practitioners working in adult or mixed practices, and 201 primary care nurses. The sample has been weighted to the country-specific features – e.g., location of the practice, residence and age of the HCWs – within each of the three groups, so from this aspect it can be considered representative. Results: Our results did not differ substantially from the international ECDC data. Approximately 2/3 of the primary care doctors and about 50% of the primary care nurses were convinced of the benefit and value of vaccines. Data on vaccine hesitancy were consolingly low, though the data on recommended vaccines were somewhat higher compared to the age related/NIP (National Immunization Plan) vaccines. The well-known vaccine scares – e.g., autism–MMR, etc., known also from the literature – could hardly been detected, and it can be explained by the voluntary participation in the study. The least supported vaccine is BCG, while the highest hesitancy rates are related to MMR in Hungary. Conclusion: The need to improve immunization-related communication among primary HCWs could clearly been detected – both in gradual and in post-gradual training programs. Orv Hetil. 2019; 160(48): 1904–1914.
“El impacto de las TIC en la vida moderna”
Authors: Briceño Díaz Freddy
Published: November 2019

Los cambios en general que se han presentado en las dos (2) últimas décadas en aspectos como: globalización, Internet, tecnologías de las comunicaciones, tratados de libre comercio, economía internacional, la política, entre otros aspectos; ha ocasionado que nuevas organizaciones hayan surgido producto de las necesidades del mismo entorno, otras han adaptado sus procesos de acuerdo con los cambios que le impone su ámbito, pero también ha ocurrido que organizaciones con muchos años de experiencia, tradición y subsistencia en los mercados nacionales e internacionales  hayan desaparecido.
Likestilt dramaturgi
Authors: Larsen Wenche
Published: November 2019

In her article, Wenche Larsen presents a heterogeneous, dramaturgical model based on an understanding of dramaturgy as the theatrical shaping and composition of material and artistic components in space and time – according to aesthetic principles. There are three concepts that form the basis of the model: Aristotle’s concept of Mythos, Knut Ove Arntzen and Hans-Thies Lehmann’s concept of ‘visual dramaturgy’, and Erika Fischer-Lichtes’ concept of performativity According to Larsen, these concepts point to three, different understandings of theatrical action – verbal, visual and physical action respectively. Larsen argues that her model can be used as an analytical tool in order to identify the various types of action in a play, although the three types of action often are interwoven.
Prognostic and Predictive Value of Microsatellite Instability, Inflammatory Reaction and PD-L1 in Gastric Cancer Patients Treated with Either Adjuvant 5-FU/LV or Sequential FOLFIRI Followed by Cisplatin and Docetaxel: A Translational Analysis from the ITACA-S Trial
Authors: Di Bartolomeo Maria , Morano Federica , Raimondi Alessandra , Miceli Rosalba , Corallo Salvatore , Tamborini Elena , Perrone Federica , Antista Maria , Niger Monica , Pellegrinelli Alessandro , Randon Giovanni , Pagani Filippo , Martinetti Antonia , Fucà Giovanni , Pietrantonio Filippo ,   on behalf of ITACA-S study group
Published: November 2019

Background

Patients with high microsatellite instability (MSI) gastric cancer (GC) show improved survival and no benefit or harm from adjuvant and/or perioperative chemotherapy. The role of immune microenvironment in GC is largely unknown.

Materials and Methods

In the present study, 256 tumor tissue blocks were centrally collected from patients enrolled in ITACA-S, a randomized adjuvant trial of 5-FU/LV versus sequential FOLFIRI and cisplatin-docetaxel. MSI status was assessed by multiplex PCR, inflammatory reaction by H&E morphological assessment, and programmed death-ligand 1 (PD-L1) expression by immunohistochemistry.

Results

Overall, 9% patients had MSI-high tumors, 23% had high inflammatory reaction, 11% had tumor PD-L1 ≥ 1%, and 11% had stromal PD-L1 ≥ 1%. A significant association with disease-free survival (DFS) and overall survival (OS) was found for MSI-high (hazard ratio [HR], 0.43; p = .02; HR, 0.40; p = .02) and high inflammatory reaction (HR, 0.55; p = .010; HR, 0.53; p = .008) but not for PD-L1. At multivariable analysis, only MSI showed an independent association with both DFS (p = .02) and OS (p = .01), whereas inflammatory reaction showed an independent association only with OS (p = .04). Patients with tumor PD-L1 ≥ 1% had a significantly longer DFS in sequential chemotherapy than in than 5-FU/LV arm (interaction p = .04) and a trend for OS (interaction p = .12).

Conclusion

Our data suggest that MSI status could be a useful prognostic biomarker in patients with radically resected stage II–III GC and should be used as stratification factor in future trials. Tumor PD-L1 ≥ 1% should be further investigated as a potential predictor of benefit from intensive chemotherapy.
Caracterización del aceite de la semilla de Sacha Inchi (plukenetia volubilis) del cantón San Vicente, Manabí, Ecuador, obtenida mediante procesos no térmicos de extrusión
Authors: Valdiviezo Carlos Jefferson , Romero Hidalgo Luis Eduardo , Bonilla Bermeo Stefanie Michelle
Published: November 2019

Sacha Inchi (plukenetia Volubilis) es una planta originaria de Perú. El fruto es una semilla oleaginosa la cual posee un alto contiene ácidos grasos polinsaturados, en la cual se destaca el omega 3 y 6. Para la extracción de este aceite se utilizó el método de compresión por extrusión, utilizando un tornillo sinfín lo que hace aumentar la presión de la masa, separando así el aceite contenido dentro de la semilla. Para esto, se utilizó un extractor experimental el cual fue adaptado y puesto en marcha para la obtención de este aceite, extrayéndolo a temperatura ambiente. Con la finalidad de establecer las características fisicoquímicas de la semilla se realizaron análisis de humedad, fibra, ceniza, grasa y proteína. Una vez extraído el aceite se calculó los rendimientos y se realizaron análisis de: índice de acidez, densidad relativa, índice de Yodo, índice de Peróxido y perfil de ácidos grasos. Estos resultados se compararon con análisis realizados al aceite de la misma especie, pero de diferentes zonas de cultivo del Perú, aceite de pescado y oliva, los cuales se los conoce por su alto contenido de ácidos grasos, dejando como resultado que el aceite de Sacha Inchi presenta un alto contenido de ácidos grasos polinsaturados y que el método de extracción influye en la calidad del producto.
Optimization of blood pressure management after acute ischemic stroke and its prognostic significance: Prospective, randomized, open, blinded outcome evaluation, and feasibility Trial v1
Authors: Joon Kim Beom
Published: November 2019

Optimization of blood pressure management after acute ischemic stroke and its prognostic significance: Prospective, randomized, open, blinded outcome evaluation, and feasibility Trial [BOSS trial]; NCT03024476 A phase II clinical trial protocol written in Korean language. Apologize not providing a translation.
Flavonol, Anthocyanin, and Chlorophyll Indices using a Force-A Dualiex Scientific+ v1
Authors: S Lebauer David , Newcomb Maria , Herrit Matthew , Babaeian Ebrahim
Published: November 2019

This protocols describes the use of a hand-held sensor to estimate polyphenols and cholorphyl content of leaves based on absorbance and transmitance of specific wavelenghts of visible and near infrared light. The instrument does not directly measure these chemical concentrations, but measures reflectance and absorbance indices that have been demonstrated to relate to leaf level concentrations. We use it to measure Chlorophyll, anthocyanin, and a nitrogen balance index. Chlorophyll Concentration (μg/cm2): The instrument is factory calibrated to measure leaf chlorophyll concentration. Flavanol Index (Flv) Anthocyanin Index Nitrogen Balance Index (NBI): a relative measure of nitrogen status Note that hte instrument documentation does not provide specific wavelenghts, only approximate wavelengths in this diagram (from ):
THE USE OF ADAPTIVE AND INTELLECTUAL EDUCATIONAL TECHNOLOGIES IN PREPARING OF MODERN SPECIALISTS
Authors: Bachov I.
Published: November 2019

In the development of educational software, there are ongoing dynamic changes that affect the market of educational services on the Internet. The current state of the distance education system requires the latest educational technology to effectively meet the needs of students who study virtually.The article defines how intelligent systems are used in the training of modern specialists through the system of distance learning.Key words: educational systems, intellectual systems, student, internet, hypermedia.
Utilization of Aquatic Weed Salvinia molesta as a Raw Material for Biogas Production
Authors: Kawaroe Mujizat , Effendi Hefni , Palupi Zidni Ilma , Hendra Neneng Sri , Lestari Dea Fauzia
Published: November 2019

Salvinia molesta is an aquatic weed having very high growth rate. The high abundance of this species biomass could be utilized as a source of alternative energy. This research was aimed to utilize S. molesta as a substrate for biogas production using batch system in order to reduce euthrofication effect in a lake. Cow manure was used as starter for anaerobic process because containing bacteria. Proximate test was conducted to analyze the chemical characteristics of the aquatic weed. Chemical oxygen demand, total solid, and total volatile suspended solid of weed and manure were analyzed according to the APHA 2012 method. Biogas composition was analyzed with gas chromatography. The results showed that the S. molesta contained high lignin content and low C:N ratio. Hydrolisis and acidification process occured very rapid, resulting in an increase of the weed and manure mixture COD. In the other hand, the decreased of COD removal was caused by the massal death of methanogenesis bacteria. The total solid and total volatile suspended solid content were not significantly decreased. Potential biogas production from S. molesta was 58.16 L.kg-1 with 318.29 mL.gram VS-1day-1 of methane production. This production value was still low or compared to that of cow manure which have been established as biogass materials and need modification to improve the biogas production.
Innovative Ways to Teach Mathematics: Are they Employed in Schools?
Authors: ABD ALGANI Yousef
Published: November 2019

This study sheds light on the various strategies
to teach mathematics and whether they are employed or not. The study
investigates the employed mathematics-teaching strategies in Arab schools in
northern Israel, and the hindrances that prevent teachers from applying diverse
effective strategies in their classrooms. The researcher follows the
qualitative approach based on in-depth interviews and recommendations of
previous studies and observation to obtain the maximum benefits and give
accurate qualitative results based on interviews, from Arab schools in northern
Israel who study in six different schools. Teachers assert that employing the
different innovative strategies are vital and efficient in teaching
mathematics, but there are many handicaps that prevent teachers from exploiting
them including, amongst others, the imposed duties to complete the entire
amount of loaded study material during the semester, as well as the lack of
available tools to computerize classes and teaching process in general, the
lack of building tangible tools, and the low proficiency level of some
teachers. The results of the interviews showed that technology is rarely
employed in teaching mathematics – if ever, as well as innovative and modern
strategies. The study concludes that the heavy burden of teaching mathematics
should be lightened to allow space for creativity in teaching strategies, as
they need more time to be employed. In addition, for mathematics to be
understood properly, the teaching process should be interesting to attract students.
Besides this, the suggested strategies are advantageous to be applied in the
teaching process.
Study of changes in levels of salivary estriol and progesterone in preterm labor in comparison to normal pregnancy
Authors: Yadav Richa , Singh Urmila
Published: November 2019

Background: This prospective research was designed to evaluate changes in levels of salivary Estriol and Progesterone in preterm labor in comparison to normal pregnancy. Spontaneous onset of labor at term is produced by definite increase in estriol and fall in progesterone. This rise in free estrogen should precede the onset of labor according with the known effect of estrogen and progesterone on myometrial activity. Concentration of steroid in saliva reflect unbound unconjugated and biologically active fraction.Methods: The present study was carried for duration of one year enrolling 115 antenatal women between 28 and < 37 weeks of gestation with or without labour pains attending the antenatal clinic in KGMU, Lucknow and those admitted in Queen Mary’s Hospital Lucknow. 5 ml of saliva was collected in cryovials from each patient to estimate estriol and progesterone. The estimation of saliva progesterone and estriol was done by immunoenzymatic colorimetric method of the supernatant of sample.Results: In our study mean value of saliva progesterone levels of pregnant women with preterm delivery (study group IIA) was lower than the control group (Group l) but the difference was not significant (3814.46±751.14 pg/ml versus 3945.16±577.11 pg/ml, p = 0.351). Mean value of estriol study group who delivered preterm (3512.85±586.16 pg/ml) was higher as compared to the mean value of control group (2691.72±681.08 pg/ml) and difference was significant (p value < 0.001).Conclusions: Thus, there is significant rise in level of saliva estriol, it can be used as a predictor for detecting symptomatic and asymptomatic women at risk for preterm birth.
Priapism: a rare presentation in chronic myeloid leukemia
Authors: Dhanju Avtar Singh , Tyagi Princy , Dhaliwal Sumitoj Singh , Paul Surender , Singh Rajbinder , Singh Jasdeep , Parmar Amardeep Singh , Singla Deepshikha , Thiyagu K.
Published: November 2019

Priapism is a rare presenting feature of Chronic Myeloid Leukemia (CML). It is an urological emergency which requires urgent treatment to prevent long term complications, in particular erectile dysfunction. Author report a case of 18 year old male presenting with persistent painful erection of penis for around 14 hours. The patient underwent immediate irrigation and decompression of priapism in emergency and was started on cytoreductive therapy. During hospitalization, peripheral blood smear and bone marrow aspiration confirmed the diagnosis of CML.
Forging the American Century: World War II and the Transformation of U.S. Internationalism
Authors: van den Berk Jorrit , Mehring Frank
Published: November 2019

This essay introduces the special issue on the forging of the ‘American Century’, which brings together American and European scholars to revisit the time between the entrance of the U.S. into World War II and the era of the European Reconstruction. Exploring the multivalent agents and forces involved in forging the American Century, the various articles bring into play national and transnational trajectories that inform politics, media and popular culture. Rather than adhering to a single theoretical approach, the articles offer a wide range of intercultural, theoretical and methodological perspectives.
Effects of pH on the activity and structure of choline oxidase from Alcaligenes species.
Authors: Hekmat Azadeh , Saboury Ali Akbar , Moosavi-Movahedi Ali Akbar , Ghourchian Hedayatollah , Ahmad Faizan
Published: November 2019

A reversible effect of pH on the ionization of amino-acid residues at the active center of choline oxidase was observed near the optimum pH (8). Inactivation of choline oxidase took place in the pH ranges 3-6 and 9-11, in which irreversible changes in the structure occur leading to the enzyme inactivation. The first order rate constants of the enzyme's inactivation at various pH values were estimated for the irreversible changes. The Arrhenius analysis revealed no significant changes in the activation enthalpy, while an increase in the activation entropy reflected an increase in the conformational freedom.
The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part.
Authors: Miciałkiewicz Arkadiusz , Chełstowska Anna
Published: November 2019

The Swc4p protein, encoded by an essential gene, is shared by two chromatin-remodeling complexes in Saccharomyces cerevisiae cells: NuA4 (nucleosome acetyltransferase of H4) and SWR1. The SWR1 complex catalyzes ATP-dependent exchange of the nucleosomal histone H2A for H2AZ (Htz1p). The activity of NuA4 is responsible mainly for the acetylation of the H4 histone but also for the acetylation of H2A and H2AZ. In this work we investigated the role of the Swc4p protein. Using random mutagenesis we isolated a collection of swc4 mutants and showed that the essential function of Swc4p resides in its N-terminal part, within the first 269 amino acids of the 476-amino acid-long protein. We also demonstrated that Swc4p is able to accommodate numerous mutations without losing its functionality under standard growth conditions. However, when swc4 mutants were exposed to methyl methanesulfonate (MMS), hydroxyurea or benomyl, severe growth deficiencies appeared, pointing to an involvement of Swc4p in many chromatin-based processes. The mutants' phenotypes did not result from an impairment of histone acetylation, as in the mutant which bears the shortest isolated variant of truncated Swc4p, the level of overall H4 acetylation was unchanged.
Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin.
Authors: Michalska Marta , Pajak Wojciech , Kołodziejska Justyna , Lazarenkow Andrzej , Nawrot-Modranka Jolanta
Published: November 2019

The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.
Authors: Smietana Katarzyna , Kasztura Monika , Paduch Marcin , Derewenda Urszula , Derewenda Zygmunt S , Otlewski Jacek
Published: November 2019

PDZ domains are ubiquitous protein-protein interaction modules which bind short, usually carboxyterminal fragments of receptors, other integral or membrane-associated proteins, and occasionally cytosolic proteins. Their role in organizing multiprotein complexes at the cellular membrane is crucial for many signaling pathways, but the rules defining their binding specificity are still poorly understood and do not readily explain the observed diversity of their known binding partners. Two homologous RhoA-specific, multidomain nucleotide exchange factors PDZRhoGEF and LARG contain PDZ domains which show a particularly broad recognition profile, as suggested by the identification of five diverse biological targets. To investigate the molecular roots of this phenomenon, we constructed a phage display library of random carboxyterminal hexapeptides. Peptide variants corresponding to the sequences identified in library selection were synthesized and their affinities for both PDZ domains were measured and compared with those of peptides derived from sequences of natural partners. Based on the analysis of the binding sequences identified for PDZRhoGEF, we propose a sequence for an 'optimal' binding partner. Our results support the hypothesis that PDZ-peptide interactions may be best understood when one considers the sum of entropic and dynamic effects for each peptide as a whole entity, rather than preferences for specific residues at a given position.
Basic energetic parameters of Acanthamoeba castellanii mitochondria and their resistance to oxidative stress.
Authors: Jarmuszkiewicz Wieslawa , Antos-Krzeminska Nina , Drachal-Chrul Danuta , Matkovic Karolina , Nobik Wioletta , Pieńkowska Joanna , Swida Aleksandra , Woyda-Ploszczyca Andrzej , Budzinska Malgorzata
Published: November 2019

The purpose of this study was establishing the basic energetic parameters of amoeba Acanthamoeba castellanii mitochondria respiring with malate and their response to oxidative stress caused by hydrogen peroxide in the presence of Fe(2+) ions. It appeared that, contrary to a previous report (Trocha LK, Stobienia O (2007) Acta Biochim Polon 54: 797), H(2)O(2)-treated mitochondria of A. castellanii did not display any substantial impairment. No marked changes in cytochrome pathway activity were found, as in the presence of an inhibitor of alternative oxidase no effects were observed on the rates of uncoupled and phosphorylating respiration and on coupling parameters. Only in the absence of the alternative oxidase inhibitor, non-phosphorylating respiration progressively decreased with increasing concentration of H(2)O(2), while the coupling parameters (respiratory control ratio and ADP/O ratio) slightly improved, which may indicate some inactivation of the alternative oxidase. Moreover, our results show no change in membrane potential, Ca(2+) uptake and accumulation ability, mitochondrial outer membrane integrity and cytochrome c release for 0.5-25 mM H(2)O(2)-treated versus control (H(2)O(2)-untreated) mitochondria. These results indicate that short (5 min) incubation of A. castellanii mitochondria with H(2)O(2) in the presence of Fe(2+) does not damage their basic energetics.
Improved HPLC method for total plasma homocysteine detection and quantification.
Authors: Sawuła Wojciech , Banecka-Majkutewicz Zyta , Kadziński Leszek , Jakóbkiewicz-Banecka Joanna , Wegrzyn Grzegorz , Nyka Walenty , Banecki Bogdan
Published: November 2019

Recent clinical research has pointed at hyperhomocysteinemia as an independent risk factor in a number of cardiovascular and neurological diseases. We have improved a chromatographic method of total plasma homocysteine measurements in order to obtain higher sensitivity, reliability and reproducibility. The method demonstrates excellent linearity (R=0.999), range (
Metabolism of conjugated sterols in eggplant. Part 2. Phospholipid : steryl glucoside acyltransferase.
Authors: Potocka Anna , Zimowski Jan
Published: November 2019

A membrane-bound phospholipid : steryl glucoside acyltransferase from Solanum melongena leaves was partially purified and its specificity and molecular as well as kinetic properties were defined. Among the steryl glycosides tested (e.g. typical plant steryl glucosides, steryl galactosides and cholesteryl xyloside) the highest activity was found with cholesteryl glucoside, but some structurally related compounds such as sito- and stigmasteryl glucoside or galactoside as well as cholesteryl galactoside were also acylated, albeit at lower rates. The investigated enzyme was able to use all classes of phosphoglycerolipids (phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol) as an acyl source for biosynthesis of acylated steryl glucoside. Among them 1,2-dimirystoylphosphatidylic acid appeared to be the best acyl donor. Apart from phosphoglycerolipids, 1,2-diacylglycerols were also used as acyl donor for steryl glucoside acylation, although at a distinctly lower rate. The acyl moiety was transferred from the C-1 position of phospholipid molecule. The investigated acyltransferase activity was stimulated by 2-mercaptoethanol, Triton X-100, 1-monoacylglycerols and inhibited in the presence of divalent cations such as Ca(2+), Mn(2+), Zn(2+) or Co(2+), some lipids (MDGD, ceramide), detergents (Tween 20, 40, 60 and 80, Tyloxapol, sodium deoxycholate) and high ionic strength.
Tissue- and stage-specific expression of a fatty acid binding protein-like gene from amphioxus Branchiostoma belcheri.
Authors: Wang Yongjun , Zhang Yuequn , Zhang Shicui , Tian Jianxiao , Jiang Shengjuan
Published: November 2019

A cDNA clone encoding an amphioxus fatty acid binding protein-like (AmphiFABPL) protein was isolated from a gut cDNA library of Branchiostoma belcheri. It contained a 423 bp open reading frame corresponding to a deduced protein of 140 amino acids with a predicted molecular mass of approximately 15.9 kDa. Phylogenetic analysis showed that AmphiFABPL fell outside the vertebrate clade of fatty acid binding proteins (FABPs), being positioned at the base of the chordate lineage, and was almost equally homologous to various vertebrate FABPs, suggesting that it may be the archetype of vertebrate FABPs. Both northern blotting and in situ hybridization analyses demonstrated that AmphiFABPL was expressed in the hepatic caecum and hind-gut, and although at a much lower level, it was also present in the endostyle, ovary and testis. In addition, whole-mount in situ hybridization revealed that AmphiFABPL was initially expressed in the posterior two thirds of the primitive gut, including the mid-gut where the hepatic caecum will form later, in 2-day larvae. The expression pattern is closely similar to that of the L-FABP and I-FABP genes in vertebrates, supporting the hypothesis that the hepatic caecum in the amphioxus is homologous to the vertebrate liver.
Cloning and purification of functionally active Fas ligand interfering protein (FIP) expressed in Escherichia coli.
Authors: Wisniewski Pawel , Master Adam , Kaminska Bozena
Published: November 2019

This report presents purification and characterization of the extracellular domain of rat Fas protein, called FIP (FasL interfering protein), expressed as inclusion bodies in Escherichia coli. FIP was extracted from the inclusion bodies, solubilized with 8 M urea, purified by a single-step immobilized metal ion (Ni(2+)) affinity chromatography and refolded. SDS/PAGE and mass spectrometry analysis of the purified protein verified its purity. Fluorescence spectrum analysis showed that the refolding procedure caused structural changes which presumably might have led to oligomerization. The purified FIP has biological activities: it binds specifically soluble Fas ligand and protects human Jurkat lymphocytes against FasL-dependent apoptosis. This efficient procedure of FIP expression in E. coli and renaturation may be useful for production of therapeutically important proteins.
Homologues of HSV-1 nuclear egress factor UL34 are potential phosphoinositide-binding proteins.
Authors: Wyrwicz Lucjan S , Koczyk Grzegorz , Rychlewski Leszek
Published: November 2019

During the herpesvirus replication cycle, viral transcription, DNA replication, formation of capsids and DNA packaging occur in the nucleus. The subsequent nuclear egress of newly synthesized nucleocapsids is performed by budding of the inner leaflet of the nuclear membrane, which creates the primary envelope. Although products of two genes conserved throughout the Herpesviridae family (HSV-1 UL34 and UL31) have previously been shown to be involved in the execution of this process, the molecular basis of their activity is not clear. Here we present results of protein structure prediction for the conserved domain of UL34. The applied methodology suggests that this protein adopts a pleckstrin homology (PH) fold to perform its function. A detailed inspection of the ligand binding site strongly supports the hypothesis that UL34 orthologs can recognize phosphoinositides. Since previous works suggest that alterations of UL34 gene product result in a drastic impairment of primary envelopment of HSV-1 and trapping of capsids in the nucleus, the presented data may lead to the development of novel anti-herpetic therapeutic strategies where analogs of phosphoinositides are administered.
O ENSINO DE ARTE E A EXPERIÊNCIA: NARRATIVAS EM TORNO DO PROJETO MORRO GRANDE EM ARTE
Authors: Miziescki Mikael , Honorato Aurélia Regina De Souza
Published: November 2019

Este presente artigo se desenvolveu em torno das quatro edições do projeto “Morro Grande em Arte”, executado na cidade de Morro Grande que está localizada no extremo sul de Santa Catarina. O projeto aconteceu na EMEF Prefeito Dário Crepaldi por meio das aulas de Artes, objetivando desconstruir estereótipos na escola e na comunidade e também oportunizar aos participantes vivências relacionadas às diferentes linguagens artísticas, valorizando a cultura local, contemplando a história da arte enquanto referencial teórico-prático, enaltecendo o processo criativo dos alunos na busca do refletir os múltiplos conhecimentos em arte e sobre arte. A proposta se construiu a partir das produções feitas pelos alunos nos anos letivos de 2014 à 2017, na perspectiva de serem potencializadas numa exposição coletiva que se propôs a ocupar espaços da cidade, como Salões de Festas e Centros Comunitários. Nas quatro edições, cerca de 1400 pessoas visitaram as exposições do projeto, contando com os trabalhos artísticos de mais de 200 alunos e 10 artistas convidados. Neste texto apresentamos nosso olhar para as múltiplas experiências estéticas produzidas pelo projeto “Morro Grande em Arte”, compreendendo a disciplina de Artes e o aluno como produtores de conhecimento crítico-reflexivo em torno de inquietações contemporâneas individuais, coletivas e culturais, considerando os efeitos de transformação na cidade e na escola. As inquietações que aqui perpassam, dialogam com autores como Honorato (2015), Rancière (2009, 2012 e 2015), Feldhaus (2014), entre outros.
Arte e racionalidade: O espaço da crítica na sociedade neoliberal
Authors: Steinmetz Cristiano José , Cechinel André , Jeremias Talia
Published: November 2019

Em torno da racionalidade neoliberal, apontamos para o caráter dialético da crítica e analisamos o que seria a crítica negativa inserida em uma sociedade positivada. Neste sentido, procuramos nos debruçar principalmente sobre algumas concepções da Teoria Crítica e suas contribuições para a discussão em torno da relação entre arte e racionalidade, pelos autores da Escola de Frankfurt e também por autores congêneres. Para isto, o ensaio se divide em dois eixos: a formação subjetivada da racionalidade comum contemporânea vinculada ao neoliberalismo; e na sequência, a relação do primeiro eixo com a receptividade da crítica negativa em exposições de arte inseridas dentro de uma arena política extremamente positivada.
Does China’s Aid in Africa Affect Traditional Donors?
Authors: Deyassa Kassaye
Published: November 2019

China’s role as an emerging aid provider and the concept of a social plan in Africa has led to polarised responses in the West. Several say that this “productivist” strategy is much less determined by the concepts of citizenship, legal, social rights, and much more regarding building functions. The purpose of this study is to examine whether the welfare and social policy ideas that characterize Chinese aid in Africa are influencing traditional donors and becoming global. The article utilised a qualitative study that has two main components. First, a comprehensive content analysis of over 50 key Sino-African, Chinese and Western policy documents from 2000 (since cooperation between Beijing and African countries first became institutionalised). Second, there were semi-structured interviews with Chinese, African and Western stakeholders in Addis Ababa, (Ethiopia), who was directly involved in the relationship between China and Africa and related development issues. The result of documentation and interview analyses show that there are currently significant differences between Chinese and Western approaches. China has made much stronger and more explicit links between development aid and economic activity than most Western donors. The aid is usually implemented through specific projects rather than broader programs or policies.
Combining ability analysis in Chilli (Capsicum Annum L.)
Authors: Chhabra Siddappa S , Ravindra M , Shashikanth E
Published: November 2019

Twenty four crosses were developed by crossing three male sterile lines with each of eight testers to study the combining ability. Crosses were evaluated along with the parents in randomized block design with two replications. Results indicated that female line KCMS-44 and tester AL were identified as good general combiners for earliness and green fruit yield per hectare. The KCMS-44 × AL was best specific cross for green fruit yield per hectare on the basis of specific combining ability effects. This study suggested the exploitation of hybrid vigor in chilli.
Effect of Coagulants on the Yield and Quality of Chhana and Rasogolla
Authors: Begum Jahura , Islam Md Nurul , Rashid Md Harun-ur , Hasssan Md Nozmul , Islam Md Zakirul , Rahman Md Mustafizur , Siddiki Mohammad Shohel Rana
Published: November 2019

A study was carried out to investigate the effect of different coagulants on the recovery of milk solids, yield and sensory quality of Chhana and the resultant Rasogolla. Six type of coagulants comprising of sour whey (0.5%, 1.0% acidity), citric acid (0.5%, 1.0% acidity) and blend of sour whey and citric acid (0.5%, 1.0% acidity) were used to prepare Chhana followed by sweet meat Rasogolla. The nonsignificant yield of chhana was found by the use of different coagulants; however it had a significant influence on the fat and total solids (TS) recoveries ranges from 90.5 to 93.8%; 42 to 44% of milk for chhana, respectively. The highest mean yield, fat recovery and TS recovery were recorded for B type chhana prepared using 1% sour whey as coagulant. Rasogollas prepared using varying coagulants did not have any significant influence on any of the sensory attributes of product studied. Rasogolla prepared from chhana made using 1% sour whey as coagulant had the highest overall sensory score. It is recommended to employ sour whey with 1.0 % of titratable acidity as coagulating agent in the preparation of Rasogolla.
Histopathological analysis of incompatible and compatible interaction of Puccinia striiformis f.sp. tritici on wheat at early infection stage
Authors: Kulshreshtha Deepika , Aggarwal Rashmi , Kumar Narendra
Published: November 2019

Stripe rust of wheat (Puccinia striiformis f.sp. tritici; Pst) incurs substantial yield losses in wheat worldwide. Two Indian Pst pathotypes 38S102 (I) and 46S119 (Yr9 virulence) showed incompatible and compatible interaction respectively in variety PBW 343. The histopathological study using confocal microscopy revealed that during incompatible interaction comparatively longer abortive germ tubes are produced with a rapid response at early stages of infection but with no fungal colonization. Whereas, in compatible interaction, germ tubes were shorter with infection peg formed above the stomata subsequently leading to colonization. The detailed microscopic observations showed that necrotic regions were more prominent in incompatible interaction than compatible interaction. This information would aid in understanding the growth and virulence mechanism of stripe rust pathogen in wheat.
ISSR based diversity analysis in beachpea [Vigna marina (Burm.) Merr.] accessions of Andaman and Nicobar Islands, India
Authors: Singh Awnindra K , Velmurugan A. . , Singh N. P. , Roy S. Dam , Biswas Utpal . , Kumar R. Rahul
Published: November 2019

Beachpea [Vigna marina (Berm.) Merr.] is a less-known food legume species, usually found near to sandy sea beaches. In the present study, a total of 17 ISSR primers were used to study the genetic diversity of 16 accessions of beachpea. The number of amplicons of genomic DNA ranged from 4 (UBC 818) to 110 (HB 13) among accessions and varied in size from 125 bp to 3000 bp. Amplification of genomic DNA of 16 accessions produced 861 amplicons, of which 588 were polymorphic (68.29%) with an average of 35 polymorphic fragments per primer. Average PIC ranged from 0.01 (UBC 809) to 0.499 (UBC 811). UPGMA analysis grouped the accessions into two main clusters, I and II comprising of 12 and 4 accessions, respectively. The Jaccard similarity coefficient between different beachpea accessions ranged from 0.38 to 1.00. The higher degree of genetic variation in the accessions revealed by ISSR analysis could be useful in characterization and conservation point of view of wild Vigna species.
Nilüfer Göle’nin Eserlerinde İslami Kimlik Arayışı ve Bu Arayışın Avrupa ve Türkiye’deki Kamusal Tezahürü
Authors: DUMAN Mehmet Zeki
Published: November 2019

Bu çalışmanın amacı, adını daha çok modernlik, sekülarizm ve İslamcılık konusunda yaptığı araştırmalarla duyuran sosyolog Nilüfer Göle’nin, siyasi bir kimlik olarak tanımladığı İslam’ın Avrupa ve Türkiye’deki yükselişini değerlendirmektir. Çalışmanın kapsamı, söz konusu yazarın, hem günümüz Türkiye’sinde sınıfsal kimliğiyle kamusallaşan ve siyasallaşan, hem de Avrupa’da modern dünyanın çağdaşı haline gelerek, gerek bireysel pratiklerde gerekse kamuya açık alanlarda tüm farklılığıyla görünürlük kazanmaya başlayan İslamcılığın bedensel ve söylemsel boyutlarına odaklanacaktır. Makalenin temel tezi, yazarın, artık İslam’ın; sadece dini bir kimlikle tanımlanamayacağı ve Ortadoğu coğrafyasıyla da sınırlı tutulamayacağı, aynı zamanda siyasal bir kimlik olarak da Batı dünyasının özellikle de dinsel ve kültürel farklılığıyla ve demokratik teamülleriyle öne çıkan Avrupa’nın daha fazla dikkate alması gerektiği yönündedir. Bu gereklilik, aynı zamanda Batı’da her geçen daha fazla ortaya çıkan ‘yabancı düşmanlığı’, ‘ırkçılık’ ve ‘İslamfobi’ gibi sorunların tartışılmasını, inançları ve aidiyetleri yüzünden dışlanan ve sorgulanan müslümanların bu konudaki hassasiyetlerinin anlaşılmasını da sağlayacaktır.
A prática pedagógica em um serviço de medidas socioeducativas em meio aberto: o desenvolvimento do projeto político-pedagógico como base do trabalho socioeducativo
Authors: Molina Selma Marquette , De Souza Neto João Clemente
Published: November 2019

Este resumo tem como base uma pesquisa em andamento que objetiva relatar e analisar a construção e a implantação do projeto político-pedagógico (PPP) em um serviço de medidas socioeducativas em meio aberto (SMSE/MA) da cidade de São Paulo. De maneira mais específica: 1) entender a função do aspecto pedagógico no SMSE/MA; 2) verificar se a elaboração do PPP pode auxiliar na efetivação das ações pedagógicas no SMSE/MA; 3) traçar indicadores para apoiar a construção de PPPs no âmbito do SMSE/MA. O referencial teórico utilizado se apoia, inicialmente, na legislação federal, estadual (SP) e municipal (SP) bem como em teóricos que discutem os conceitos de pedagogia, PPP, pedagogia social e suas práticas, como Veiga, Caliman e Freire. Metodologicamente, trata-se de uma pesquisa de abordagem diagnóstica, do tipo exploratória, desenvolvida no formato de estudo de caso. Foram utilizados como fonte de dados: a) documentos – atas de reuniões, estudos de caso, supervisão institucional e avaliações realizadas pelos adolescentes/jovens atendidos no SMSE/MA; b) entrevista semiestruturada com seis profissionais do SMSE/MA. Para organização e análise dos dados, utilizou-se o método de núcleos de significação. A pesquisa, inicialmente, expressa resultados preliminares no sentido de que o PPP favorece a práxis dos educadores, por sua organicidade e por se relacionar com o cotidiano por eles vivenciado.
Effect of Silicon Application on Wheat Under Boron Stress
Authors: Erkan İbrahim Ertan
Published: November 2019

In this study, effects of different silicon (Si)
concentrations (0.75, 5, 10 mM) on wheat under boron(B) stress, investigated by
means of some stress indicators such as tissue length, malondialdehyde (MDA),
ion leakage, relative water content (RWC) and total chlorophyll content. Stress
mitigating effects of silicon were observed mainly as reductions on membrane
damage with reduced MDA concentrations and decreased ion leakage levels. Although
necrosis was present on shoot tissues due to the boron stress, no significant
change observed on shoot and root length with the application of Si. On the
contrary, relative water content (RWC) has changed positively with the
implementation of Si under boron stress. Furthermore Si has enhanced RWC level
in Si+B co-applicated sets to the level of control plants. Total chlorophyll
content increased with the existance of 0.75 and 5 mM Si, while 10 mM Si had no
effect on the chorophyll content under boron stress. Overall, silicon was found
to have a potential to alleviate boron stress in wheat production.
El Paraíso, el paisaje y la lejanía en América de Kafka
Authors: Vadillo Juan
Published: November 2019

En este artículo abordamos la novela América, de Franz Kafka, a partir de tres motivos centrales: el paraíso, el paisaje y la lejanía. Intentamos señalar de qué manera el paraíso y el mundo terrenal recorren paralelamente la trama de la novela. La descripción del paisaje nos ofrece una ventana al paraíso, pero inevitablemente regresamos al mundo terrenal. Se trata de un diálogo contrapuntístico entre el paraíso y la tragedia, donde la mujer entraña ambos, una puerta al paraíso, y la expulsión de éste.
International Legal Format for Trans Regionalisation of Trade and Economic Partnership within BRICS in Global Development
Authors: Luzina Tatiana V. , Dudareva Elsa A. , Akhmetshin Elvir M. , Prodanova Natalia A. , Berdova Yuliya S. , Emaletdinova Galina E.
Published: November 2019

An integral part of globalisation is the emergence of a multipolar world. Strategic partnership at the regional, interregional and trans-regional levels is becoming a new institution and an instrument of modern international relations. The research discusses the international legal cooperation framework of BRICS (Brazil, Russia, India, China, South Africa) as a trans-regional association. The importance of rapprochement of the positions of the BRICS countries in the global political and economic system is emphasised. Particular attention is paid to assessing the BRICS countries economic potential and condition of their national economies, as well as analysing the foreign trade partners of Russia with the BRICS countries, development opportunities and prospects. The following results were obtained: positive factors contributing to the BRICS countries’ trade and economic cooperation strengthening are common interests in trade, export activity and export complementarity of some economic sectors, and the absence of direct competition. The measures to increase and expand mutually beneficial trade and economic partnership within BRICS will enable the countries to most effectively use their resource, technological and trade and economic potential to ensure sustainable growth of the national economy and competitiveness in world development. The results obtained can help formulate a trade and economic cooperation strategy within the BRICS framework.
Networking Cooperation in Forming Soft Skills of a New Type of Teacher
Authors: Rebrina Fayruza G. , Khakimova Sabina D. , Ishkinyaeva Ann R.
Published: November 2019

The primary aim of this research is to develop an effective network interaction model in developing a new teacher’s soft skills. The authors carried out an analysis of a new teacher’s necessary soft skills and the existing models of partnerships. They outlined their views on the development of a networking model that is aimed at the systematic formation of a teacher’s soft skills. The empirical part is executed based on the Elabuga Institute of the Kazan Federal University. The created model can be used for the organisation of training system of a new type of teacher. It might as well be used as a model of the school-university partnership for revealing pedagogically gifted children or as an integrated model for the formation of basic teachers’ soft skills in the university.
Development of certified reference materials for physicochemical analysis. Certified reference solutions for the composition of aqueous aluminum, indium, magnesium, nickel and titanium
Authors: Ermakova I. I. , Ivanov A. V. , Zyablikova I. N. , Shobina A. N.
Published: November 2019

This paper presents information on the development and certification of reference materials (CRM) for the composition of aqueous aluminium, indium, magnesium, nickel, and titanium solutions.

CRMs are represented by aqueous solutions containing aluminium, indium, magnesium, nickel, and titanium ions. CRMs have been packed into 5, 10 and 25 cm3 glass ampoules, as well as into 50 and 250 cm3 polypropylene vessels. The certified values of metal mass concentrations were established according to the preparation method.

The certified value of the mass concentration of metal ions in the CRMs under study is found to vary within the range of 0.95–1.06 g/dm3. Both the relative expanded uncertainty (under k= 2) of the certified mass concentration and the relative standard uncertainty due to instability do not exceed the values of 0.8 % and 0.069 %, respectively. The developed CRMs are shown to have the shelf life of 3 years provided that standard storage conditions are ensured. The developed CRMs are included into the RF State Register of Certified Reference Materials under the following numbers: CRM 11122–2018, CRM 11123–2018, CRM 11124–2018, CRM 11125–2018, and CRM 11126–2018. The CRMs produced by the All-Russian Research Institute for Optical and Physical Measurements (VNIIOFI) are characterized by the values of expanded uncertainty comparable to those of world leaders in the production of similar materials.
Landslide Inventory (2001-2017) of Chittagong Hilly Areas, Bangladesh
Authors: Rabby Yasin Wahid , Li Yingkui
Published: November 2019

Abstract: Landslide is a frequent natural hazard in Chittagong Hilly Areas (CHA), Bangladesh, which causes the loss of lives and damage to the economy. Despite that, an official landslide inventory is still lacking in this area. In this paper, we present a landslide inventory of this area prepared using the visual interpretation of Google Earth images (Google Earth Mapping), field mapping, and literature search. We mapped 730 landslides that occurred from 2001 to 2017. Different landslide attributes, including type, size, distribution, state, water content, future risk, and causes, are presented in the dataset. In this area, slide and flow were the two dominant types of landslides. Among five districts (Bandarban, Chittagong, Cox's Bazar, Khagrachari and Rangamati), most (54.93%) of the landslides occurred in Chittagong and Rangamati districts. About 45.09% of the landslides were small (<100 m2) in size while the maximum size of the detected landslides was 85201.6 m2. This dataset will help to understand the characteristics of landslides in CHA and provide useful guidance for policy implementation.