bluuebunny/crossref_metadata_2025 huggingface dataset:
Moradas do belo na educação
Authors: Hardt Lúcia Schneider
Published: April 2021

O artigo destaca a reflexão sobre o belo, abordado no campo filosófico, para pensar os seus possíveis desdobramentos pedagógicos. Ancorado em vários autores, por vezes até dissonantes entre si, o artigo pretendeu priorizar o exercício de uma prática ainda necessária: superar o pensamento dualista, em que as lentes estariam focadas em destacar um dos lados para extinguir os demais. A morada do belo depende de muitas perspectivas, não será possível aprisioná-lo em um só lugar, conceito ou autor. O belo movido pela arte, pelo trágico e pela vida escapa sempre de apressadas conclusões e quer nos ver em movimento para sofisticar ainda mais as possíveis expressões deste existir humano. O destino da reflexão é o campo da educação, com o intuito de devolver a ela o direito a pensar e fazer o belo se materializar nas inúmeras possibilidades de formação humana.Palavras-chave: Belo. Filosofia da Educação. PedagogiaThe homes of beauty in educationABSTRACT The article highlights the reflection on the beauty, approached in the philosophical field, to think about its possible pedagogical consequences. Anchored by several authors, sometimes even dissonant with each other, the article intended to prioritize the exercise of a still necessary practice: overcoming dualistic thinking, where lenses would be focused on highlighting one side to extinguish the others. The home of beauty depends on many perspectives, it will not be possible to imprison it in one place, concept or author. Beauty, moved by art, tragic and life, always escapes hasty conclusions and wants to see us moving to further sophisticate the possible expressions of this human existence. The fate of reflection is the field of education in order to return to it the right to think and make the beauty materialize in the countless possibilities of human formation.Keywords: Beauty. Philosophy of Education. Pedagogy,Moradas de la belleza en la educaciónRESUMENEl artículo destaca la reflexión sobre lo bello, abordado en el campo filosófico, para pensar en sus posibles consecuencias pedagógicas. Anclados por varios autores, a veces incluso disonantes entre sí, el artículo pretendía priorizar el ejercicio de una práctica aún necesaria: superar el pensamiento dualista, donde las lentes se centrarían en resaltar un lado para extinguir los otros. La morada de la belleza depende de muchas perspectivas, no será posible encarcelarla en un solo lugar, concepto o autor. La belleza, movida por la arte, lo trágico y la vida, siempre escapa a conclusiones apresuradas y quiere vernos en movimiento para sofisticar aún más las posibles expresiones de esta existencia humana. El destino de la reflexión es el campo de la educación para devolverle el derecho a pensar y hacer que lo bello se materialice en las innumerables posibilidades de la formación humana.Palabras clave: Bello. Filosofía de la Educación. Pedagogía.
Return Migration, Reverse Culture Shock: A Critical Analysis of Their Patterns and Particularities Amongst Migrant Nigerian Elites
Authors: Adeniyi Abiodun G. , Onyeukwu Pauline E.
Published: April 2021

Migration has remained a constant element of 21st-century changes (Appadurai, 1999; Gillespie, 2000; Georgiou, 2001). The prospects of a continuation are certain with growing gains in technologies of communication, transportation, and the increasing ease with which the world can integrate and function. The place of Nigerian migrants as reflected in some patterns and particularities (Georgiou, 2001; Adeniyi, 2008) of its elites reveals key characteristics useful for the understanding of discourses around migrants’ return and reverse culture shock (Naficy, 1999). While the coming home is often imagined, a few have proceeded to actualizations, and subsequently opening up new pedestals for the understanding of travelling and dwelling (Morley, 2000). This paper attempts a critical analysis of identifiable features and concludes that the revelations will ceaselessly grow in substance. The paper uses critical discourse analysis to evaluate the experiences of some elites, as rendered in formal and informal interviews, while also spicing it up with secondary data, obtained from media reports, and related literature. It eventually ended with a recommendation on the need for concerted development efforts to enable a realization of the likely higher quality lifestyle, which the elite might have left behind in the West.
Effect of Tumor Necrosis Factor-α on in vitro Prostaglandin Production in Buffalo Corpus Luteum
Authors: Tripathi M.K. , Mondal S. , Reddy I.J. , Mor A.
Published: April 2021

Background: Corpus luteum plays key role in embryonic survival. Prostaglandins are the important regulator controlling the life span of corpus luteum. The present study investigated the effect of various doses of TNFα on in vitro PGF2α and PGE2 production and expression profiling of PGFS and PGES mRNA in buffalo Corpus Luteum (CL). Methods: Buffalo ovaries with mid-luteal phase CL were collected from the abattoir and CL were enucleated from surrounding tissues. Corpus luteum were finely chopped, rinsed with HBSS (Hanks Balanced Salt Solution) medium; supplemented with gentamycin and 0.1% BSA and incubated at 37°C for 1 hr in HBSS containing 0.1% collagenase. The cell suspension following filtration was washed by HBBS supplemented with gentamycin and 0.1% BSA (bovine serum albumin) and was treated with increasing doses of TNFα (0.1, 0.5 and 1.0 nM) and cultured at 38.5°C, 5% CO2 level for 24 hr. Result: There was dose dependent increase in concentrations of PGF2α and PGE2 with increasing doses of TNFα. The PGFS (prostaglandin F synthase) mRNA expression increased with increasing doses of TNFα. However, there was decrease in PGES (prostaglandin E synthase) mRNA expression at 0.1 nM and 0.5 nM TNFα but PGES mRNA expression increased at 1.0 nM TNFα as compared to control. It can be concluded that TNFα may alter PGES and PGFS mRNA expression and prostaglandin secretion in buffalo CL.
Identification of Source of Resistance to Horse Gram Yellow Mosaic Disease (HgYMD) in French Bean (Phaseolus vulgaris L.)
Authors: Das Arindam , Aghora T.S. , Reddy M. Krishna , Nandeesha P. , Venugopalan R.
Published: April 2021

Background: Horse gram yellow mosaic disease (HgYMD) is one of the major limiting factor for legumes production in India as it can cause economic loss up to 100%. Till date, horse gram yellow mosaic virus was rare to infect french bean, but now-a-days, it has become the major causal agent for yellow mosaic epidemics in the southern part of India. Few bush type varieties, resistant to yellow mosaic disease are released but not specifically resistant to HgYMD. So, systemic breeding work has been initiated to identify the resistant source for HgYMD in french bean. Methods: Seventyone genotypes of french bean were screened in a randomized complete block design (RCBD) with three replications under natural epiphytotic as well as artificial condition during Summer, 2018 at ICAR-IIHR, Bengaluru, India. Result: The genotypes varied for per cent disease index (PDI), area under disease progress curve (AUDPC) and the apparent rate of infection per unit time period (r). Two varieties i.e., Jade-5058 and Arka Arjun were showing less PDI of 13.33 and 14.44, least average rate of infection of 0.64 and 0.65 and lowest AUDPC value of 350.54 and 359.16 respectively, compared to other genotypes. Average PDI of Arka Arjun and Jade-5058 were 13.33 and 12.22 under artificial screening, which were much lesser than susceptible check Arka Komal (PDI 92.22) and Arka Anoop (PDI 90.00). Resistant genotypes identified from this experiment can be used for breeding HgYMD resistant french bean lines.
Ticks of the genus Rhipicephalus Koch, 1844 in Senegal: Review host associations, chorology, and associated human and animal pathogens
Authors: Sylla Massamba , Souris Marc , Gonzalez Jean-Paul
Published: April 2021

Ticks of the genus Rhipicephalus (Acari: Ixodidae) in Senegal were reviewed. The data presented originate from a tick collection maintained at IRD’s Laboratory of Medical Entomology since 1967 and continuously enriched with samples obtained from different vertebrate hosts captured during various projects conducted in Senegal from 1987 to 2007. Fifteen Rhipicephalus tick species were collected and characterized, resulting in 1127 referenced collections. Three species were of the Boophilus subgenus: Rhipicephalus (Bo.) annulatus, Rh. (Bo.) decoloratus and Rh. (Bo.) geigyi. The twelve others were Rh. boueti, Rh. cuspidatus, Rh. evertsi, Rh. guilhoni, Rh. lunulatus, Rh. muhsamae, Rh. sanguineus, Rh. senegalensis, Rh. sulcatus, Rh. tricuspis, Rh. turanicus and Rh. ziemanni. Although there were recent indications that Rh. turanicus should have been considered as part of the Rh. sanguineus s.l. complex, data regarding these two ticks were presented separately. The collection comprised 14,165 tick specimens at different developmental stages. Data concerning their host relationships as well as distribution and seasonal dynamics were also presented. Vertebrate hosts were identified and listed in the different ecological zones of Senegal. The role of the ticks as potential vectors of pathogens has been reviewed. Climate change, causing variations in rainfall and temperature, will impact tick distribution and dynamics. The situation supports the necessity of this inventory of tick populations for (re)emerging tick-borne diseases surveillance and monitoring.
Performances zooéconomiques de taurillons de race Borgou complémentés avec du Vitanimal au Bénin
Authors: Guidimê Léopold Sènouwa , Kpérou Gado Byll Orou , Djènontin André Jonas , Imourou Sidi Habirou , Babatoundé Sévérin
Published: April 2021

Afin de permettre aux animaux d’améliorer leur potentiel de production notamment en saison sèche où le fourrage devient rare et de qualité médiocre, des compléments alimentaires sont de plus en plus mis à leur disposition. L’effet du Vitanimal, aliment fabriqué industriellement, mélange de coques et de tourteau de coton, a été testé chez 15 taurillons de race Borgou à la Ferme d’élevage de l’Okpara afin de mesurer son impact sur la croissance des bovins. Ces derniers ont été répartis en trois lots de cinq taurillons chacun avec un poids moyen de 103 ± 22 kg. Ils ont reçu la ration de l’aliment testé avant et après le pâturage en parts égales. Le lot 1 sans complément était le lot témoin, les lots 2 et 3 ont bénéficié respectivement de 1 et 2 kg par jour du complément alimentaire Vitanimal. Les refus ont été quantifiés. Les animaux ont bénéficié également d’eau et de pierres à lécher ad libitum. Des pesées ont été effectuées tous les quinze jours pendant 90 jours. Les analyses ont souligné une différence significative (p < 0,05) entre les lots 2 et 3 dans l’ingestion de l’aliment testé. Les résultats ont montré un effet significatif du Vitanimal sur la croissance des taurillons. Les gains moyens quotidiens dans le lot témoin, dans le lot 2 et dans le lot 3 ont été respectivement de 386 ± 147 g, 652 ± 115 g et 927 ± 160 g. L’impact du Vitanimal a ainsi été fonction de la quantité distribuée et la ration du lot 3 s’est révélée économiquement plus rentable, soit 238 % de taux de rentabilité économique contre 232 % pour le lot 2.
A paisagem no Geopark Aspirante Seridó
Authors: Silva Tamires Aparecida Souza , Silva Cláudia Patrícia Araújo e , Marins Luis Henrique
Published: April 2021

Considerando a relevância do ensino de Geociências e a importância que os Geoparques vêm desenvolvendo neste sentido, este trabalho surge do debate acerca do processo de inclusão à pessoa com deficiência nestes espaços, utilizando elementos do Desenho Universal. Buscando tornar a popularização do conhecimento geológico mais acessível, atingindo o maior número de grupos possíveis, esta pesquisa tem como objetivo contribuir com os projetos desenvolvidos no território do Geoparque Aspirante Seridó, por meio da elaboração de uma proposta de Trabalho de Campo no Geossítio Morro do Cruzeiro - Currais Novos/RN, contemplando o estudo da paisagem na perspectiva inclusiva. Para isso, a proposta foi pautada na literatura especializada na área acerca da educação inclusiva. Foi proposto um roteiro contendo as etapas de pré-campo e em campo – estando este último organizado em três momentos específicos: percepção da paisagem; aprendendo sobre a paisagem; e uma atividade de socialização das práticas desenvolvidas no dia.
Estancia hospitalaria y soporte nutricional en pacientes de un hospital de Lima, 2016
Authors:   , Cabrejos Quevedo Ángela María
Published: April 2021

La presente investigación tiene por objetivo determinar la relación entre los tipos de soporte nutricional y estancia hospitalaria. Material y métodos: Estudio descriptivo, observacional, transversal y retrosprospectivo. La muestra estuvo conformada por 43 pacientes adultos de uno y otro sexo hospitalizados en una unidad de cuidados intensivos que recibieron soporte nutricional en un hospital de Lima en el año 2016 que inciaron soporte nutricional a los 5 días de ingreso durante un mínimo de 5 días. El muestreo fue no probabilístico por inclusión consecutiva. Resultados: No se halló relación significativa entre los tipos de soporte nutricional y la estancia hospitalaria. El 63% de pacientes fueron del sexo masculino, la edad promedio fue de 65.2 (DE± 17). El 58% fueron adultos mayores; respecto a los tipos de soporte nutricional, el enteral fue 86%, el tipo parenteral (7%) y mixto (7%). El 32.6% de pacientes procedieron de cirugía, el 30.2% tuvieron problemas respiratorios, 20.9% problemas cardiovasculares, la mitad de los pacientes tuvieron un estado nutricional normal, 21% desnutrición y 27% sobrepeso y obesidad. Conclusiones: No hubo relación significativa entre los tipos de soporte nutricional y la estancia hospitalaria en la muestra estudiada.
Diseño de red social para la difusión de oportunidades laborales inclusivas contribuyendo con el aumento de posibilidades de contratación de mujeres jóvenes trans del Perú
Authors:   , Ferrando Cáceres Giovanna Graziela
Published: April 2021

Las mujeres trans en el Perú llevan años sufriendo una serie de violencias terminando en algunos casos con consecuencias devastadoras para su integridad física y emocional, debido entre muchas causas a la exclusión social de la que son víctimas. Esta violencia y exclusión por ejemplo se refleja en la dificultad para acceder a una educación de calidad que le permita un trabajo digno permitiéndole acceder a una calidad de vida respetable. Es así que se observa que a pesar de la existencia de iniciativas por parte de organizaciones no gubernamentales que apoyan y capacitan a diferentes organizaciones proveedoras de empleo sobre la aplicación de políticas de no discriminación y de inclusión estas no llegan a ser suficientes, reflejándose en la casi nula aceptación de empleadas transgénero en diversos sectores de la mediana y micro empresa; incluso en las grandes corporaciones su presencia es casi nula. Es así que se diseña una red social con una visión más inclusiva y de igualdad de oportunidades que ofrece una oferta laboral más amplia y con mayores criterios de equidad. Para lograr mayores posibilidades de empleo, se ha destinado dirigir este proyecto a los nuevos emprendedores de pequeñas o medianas empresas que estén buscando nuevos talentos para incluirlos en sus equipos de trabajo y que al unirse a la red social logren ser sensibilizados por medio de capacitaciones virtuales se fomente la visión de equidad e inclusión.
Assessment of Cereal Self-Sufficiency and Food Balance Projection in Afghanistan
Authors: Samim Sayed , Zhiquan Hu , Wen Yu
Published: April 2021

Afghanistan is overwhelmed with food insecurity that is a large percentage of the population lacks reliable access to food supplies. Grains play a vital role in the country's food security due to their importance in terms of consumption and production quantity. This paper estimates cereal self-sufficiency and then makes a food balance forecast of the three major food crops cultivated in Afghanistan over six-decades. Descriptive statistics and coarse metric techniques were employed to determine cereal self-sufficiency and food balance forecast. The econometric analysis demonstrated that (1) Afghanistan is not yet self-sufficient in meeting grain consumption, and the production and consumption ratio declined from 0.9 to 0.55 from 1979 to 2030. (2) The gap of theoretical food imbalance will increase, and by the year 2030, cereal production will likely be sufficient for only 49.8 percentage of inhabitants, leaving a high shortage equivalent to the amount required by 24.4 million people. By evaluating the quantitative food balance and the growing population change, this study presents an analysis of the emerging threat to Afghanistan's food security and suggests a solution for food security, should increase the size of public agricultural expenditure, improve the level of agriculture infrastructure, and continue to introduce a policy to achieve higher yield.
Tunable Broadband RF Photonic Fractional Hilbert Transformer Based on a Soliton Crystal Microcomb
Authors: Tan Mengxi , Xu Xingyuan , Moss David
Published: April 2021

We demonstrate an RF photonic fractional Hilbert transformer based on an integrated Kerr micro-comb source featuring a record low free spectral range of 49 GHz. By programming and shaping the comb lines according to calculated tap weights for up to 39 wavelengths across the C-band, we achieve tunable bandwidths ranging from 1.2 to 15.3 GHz as well as variable center frequencies from baseband to 9.5 GHz, for both standard integral and arbitrary fractional orders. We experimentally characterize the RF amplitude and phase response of the tunable bandpass and lowpass Hilbert transformers with 90 and 45-degree phase shifts. The experimental results show good agreement with theory, confirming the effectiveness of our approach as a powerful way to implement standard and fractional order Hilbert transformers with broad and variable bandwidths and center frequencies, with high reconfigurability and greatly reduced size and complexity. Tan, and D. J. Moss are with the Optical Sciences Centre, Swinburne University of Technology, Hawthorn, VIC 3122, Australia. (Corresponding e-mail: dmoss@swin.edu.au). Xu is with the Electro-Photonics Laboratory, Department of Electrical and Computer System Engineering, Monash University, Clayton, 3800 VIC, Australia
Assessment of NF-κB Inhibitor (SN50) Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression
Authors: Al-Dagheri Nasser M. , Alfadda Assim A. , Sallam Reem M. , McTernan Philip G. , Bin Dahman Lotfi S.
Published: April 2021

Central adiposity is one of the significant determinants of obesity-related hypertension risk, which may arise due to the abdominal fat depot's pathogenic inflammatory nature. Pro-inflammatory cytokines and adipokines up-regulation through nuclear factor-kappa B (NF-κB) activation in adipose tissue has been considered an essential function in the pathogenesis of obesity-related hypertension. This study aimed to ascertain the NF-κB inhibitor (SN50) effect on TNF-α and angiotensinogen (AGT) secretion and expression in mediating the anti-inflammatory effect through its impact on NF-κB activity in humans adipose tissue. Primary human adipocytes were isolated from 20 subjects among 10 overweight and 10 obese with and without hypertension and treated with 10ng/ml LPS in the presence and absence of NF-κB inhibitor, SN50 (50μg/ml). TNF-α secretion and NF-κB p65 activity were detected in supernatants extracted from cultured cells treated and untreated with LPS (10ng/ml) and SN50 (50μg/ml) using enzyme-linked immunosorbent assay (ELISA). The western blot technique detected the protein of NF-κB p65 and AGT. Gene expression of TNF-α and AGT was detected in cells and performed using quantitative real-time polymerase chain reaction (RT-PCR). Treatment of AbdSc adipocytes with LPS (10ng/ml) caused a significant increase in NF-κB p65 among overweight and obese subjects with and without hypertension (P= 0.001) at 24 hours incubation. In contrast, SN50-NF-κB inhibitor causes a reduction of NF-κB p65 in overweight (P= <0.001) and obese subjects with and without hypertension (P= 0.001) at 24 hours incubation. Treatment of AbdSc adipocytes with 10ng/ml LPS caused a significant increase in TNF-α secretion in overweight and obese subjects at all-time points (P= <0.001), whereas SN50 leads to a decrease in TNF-α secretion at 3 and 12 hours incubation. Treatment of AbdSc adipocytes with LPS (10ng/ml) caused increased TNF-α and AGT gene expression twofold compared with untreated cells, whereas, in the presence of SN50, it reduces mRNA AGT levels in both groups. Taken together, these adipokines with NF-κB activation may represent essential biomarkers to evaluate hypertension risk and to provide insight into the pathogenesis of obesity-related hypertension.
The Influence of Social Family Support on Depression, Anxiety and Quality of Life Among Women with Breast Cancer: Literature Review
Authors: Rahayu Tutik , Glorino Rumambo Pandin Moses
Published: April 2021

Background: Breast cancer is the second type of cancer diagnosed in women and is the first cancer in women worldwide. Breast cancer also causes high morbidity and mortality in women and becomes a heavy burden due to the incidence of disability due to the disease. Purpose: This literature review aims to examine how social support affects anxiety, depression and quality of life in breast cancer sufferers. Method: The data were obtained by searching for reputable and trustworthy journals. have high quality criteria, namely Scopus, Proquest, Science Direct, Elsevier, Pubmed. Journals or articles used in this review literature are searched using keywords and Boolean operators (AND, OR NOT, or AND NOT). Keywords in this review literature are as follows: social support OR family support, quality of life OR Quality, anxiety OR depression, AND Cancer OR cancer treatment OR Chronic disease. Results: The results of this literature review show that there is a significant influence between the social support received by breast cancer patients on the improvement of their quality of life. The social support provided is also able to reduce anxiety and depression in breast cancer sufferersConclusion: Social support given to breast cancer patients is proven to have an effect on improving the quality of life, reducing anxiety and depression.
The Gut Microbiome in Western and Indigenous Cultures
Authors: Das Santanu , Andrighettti Tahila , Sabino João , Korcsmaros Tamas , Rohman Khan Mojibur , Vermeire Severine , Sudhakar Padhmanand
Published: April 2021

The mammalian gut ecosystem plays critical roles in multiple functions related to health and homeostasis. In many cases, disturbances in the gut ecosystem are associated with a large number of metabolic and chronic diseases and disorders such as diabetes, cancer, and obesity. A diverse community of microorganisms ranging from viruses to bacteria comprise the gut microbiota, which is often considered as an organ in itself. Recent studies have profiled the influence of lifestyles and dietary behavior by comparing the gut microbiome of populations with different cultural underpinnings. In this review, we provide an overview of the studies which report the influence on the gut microbial composition of dietary and lifestyle patterns in different contexts such as western industrialized countries and indigenous cultures (corresponding to different lifestyle gradients such as hunter-gatherers and pastoralists) and how this association may influence health and disease.
On the Role of Vascularization in Pathoconnectomics
Authors: Manuello Jordi , Vercelli Alessandro , Costa Tommaso , Cauda Franco
Published: April 2021

In recent years, pathoconnectomics emerged as an interesting framework for the investigation and better comprehension of disorders affecting the brain. Research in this field has used so far structural, functional, metabolic and genetic data, but limited attention was addressed to the possible role of vascularization. In the present work the following aspects making it a valuable candidate to pathoconnectomics investigation are discussed: i) The vascular system is by its nature a network, endowed with directionality information on the basis of circulation; ii) The current imaging techniques allow in vivo detection of the vascular system to a good level of detail; iii) The information extracted from this kind of data could interact in a meaningful way with the functional profile of the brain, being the BOLD effect in turn based on blood flow; iv) Further evidence could be found in support of the trophic failure hypothesis; v) Data about vascularization could allow to bring in the pathoconnectomics framework cardiovascular and metabolic disorders. We suggest, therefore, that the evaluation of vascular connectivity (which we propose to name “vesselomics”) could enhance the pathoconnectomics paradigm, and provide new elements towards the understanding of brain pathology.
Bölgesel Kalkınmada Yerel Yönetimlerin Rolü: Konya Örneği
Authors: ARSLAN Erdal , ÇETİNER Tuğçe
Published: April 2021

Amaç: Bu çalışma ile kalkınmada yerel yönetimlerin rolünü ortaya koymak, Konya’nın yerel kalkınmasına fayda sağlamak ve yeni kalkınma stratejilerinin geliştirilmesinde yararlanılabilecek örnek bir çalışma gerçekleştirerek literatüre katkıda bulunmak hedeflenmiştir.

Tasarım/Yöntem: Araştırmada tesadüfi örneklem yöntemlerden biri olan kota örneklem yöntemiyle belirlenen 150 katılımcıya ulaşılmış ve 100 katılımcıdan geri dönüş sağlanarak anket çalışması yapılmıştır. Anket sorularında 5’li Likert ölçeği kullanılmıştır. Ulaşılan sonuçlar SPSS 15.0 programı ile analiz edilmiştir.

Bulgular: Analiz sonuçlarına bakılarak, kalkınmada yerel aktörlerin üstlendikleri rollerin ve karşılaşılan sorunların birçok noktada benzerlik gösterdiğini söylemek mümkündür. Yerelde hizmet sağlamaları nedeniyle bölge koşullarına hâkim olan yerel aktörlerin birçoğu kaynak sıkıntısı çekmekte ve ortaklaşa çalışmada zorluklar yaşamaktadır.

Sınırlılıklar: Örneklemin yalnızca Konya ilindeki yerel aktörlerden oluşması, anket sorularının Konya ilinin kalkınma düzeyine ve kalkınma sorunlarının nedenlerini ortaya koymaya yönelik olarak hazırlanması çalışmanın sınırlılıklarıdır.

Özgünlük/Değer: Konuyla ilgili literatür taraması yapılmış ve benzer birkaç çalışmaya ulaşılmış olmasına rağmen Konya ili özelinde bir araştırmaya rastlanmamıştır. Bu nedenle konu özgün bir değer taşımaktadır. Ayrıca kalkınma ve yerel yönetim konuları üzerine hazırlanmış multidisipliner bir araştırma olması da çalışmanın değerini arttırmaktadır.
Desenvolvimento de Novo Método de Beneficiamento Mecânico de Liga de Magnésio Forjada
Authors: Oliveira Ferreira Rafael Franklim , Fávero Gabriela , Simões de Lima Diego Rodolfo
Published: April 2021

A liga de magnésio AZ61 recristalizada comercialmente foi submetida a dois processos distintos de conformação mecânica a quente, o forjamento convencional e o forjamento multiaxial com 3 passes de deformação, ambos a uma temperatura de 350 ºC. Também houve a realização de tratamento térmico de solubilização e envelhecimento artificial (T6). A evolução microestrutural e das propriedades mecânicas foram investigadas e comparadas à matéria prima. O forjamento convencional proporcionou um bom acabamento superficial. Com avaliação microestrutural de uma região das peças forjadas sem tratamento térmico verificou-se que não houve recristalização. Os resultados obtidos indicam que o forjamento Multiaxial pode proporcionar ganhos consideráveis para as propriedades mecânicas do material quando comparado ao forjamento convencional.
Immune Responses in an Infant with Congenital Heart Disease and Severe COVID-19 
Authors: Licciardi Paul , Wurzel Danielle , Neeland Melanie , Anderson Jeremy , Abo Yara-Natalie , Do Lien Anh Ha , Donato Celeste , Bines Julie , Toh Zheng Quan , Higgins Rachel , Jalali Sedi , Cole Theresa , Subbarao Kanta , McMinn Alissa , Dohle Kate , Haeusler Gabrielle , McNab Sarah , Alafaci Annette , Overmars Isabella , Clifford Vanessa , Lee Lai-Yang , Daly Andrew , Buttery Jim , Bryant Penelope , Burgner David , Steer Andrew , Tosif Shidan , Konstantinov Igor , Duke Trevor , Pellicci Dan , Crawford Nigel
Published: April 2021

Children have lower hospitalisation and mortality rates for coronavirus disease-2019 (COVID-19) than adults; however, younger children (<4 years of age)1 may develop more severe disease than older children. To date, the immune correlates of severe COVID-19 in young children have been poorly characterized. We report the kinetics of immune responses in relation to clinical and virological features in an infant with acute severe COVID-19. Systemic cellular and cytokine profiling showed initial increase in neutrophils and monocytes with depletion of lymphoid cell populations (particularly CD8+ T and NK cells) and elevated inflammatory cytokines. Expansion of memory CD4+T (but not CD8+T) cells occurred over time, with predominant Th2 bias. Marked activation of T cell populations observed during the acute infection gradually resolved as the child recovered. Significant in vitro activation of T-cell populations and robust cytokine production, in response to inactivated SARS-CoV-2 stimulation, was observed 3 months after infection indicating durable, long-lived cellular immune memory.
Diverse key nitrogen cycling genes nifH, nirS and nosZ associated with mangrove rhizosphere soils of Pichavaram as revealed by culture dependent and independent analysis.
Authors: Viswanathan Baskaran , ramalingam Prabavathy vaiyapuri
Published: April 2021

PCR-DGGE and culturable diversity analysis of nitrogenase gene nifH and denitrifying genes nirS and nosZ affiliated with heterotrophic and unculturable bacterial communities associated with rhizosphere of A. marina, R. mucronata, S. maritima and S. brachiata revealed the dominance of gammaproteobacterial community across the rhizospheres. Sequence analysis of the PCR-DGGE profiles of nifH genes clustered to unculturables, while majority of the nirS and nosZ genes clustered with unculturables with few culturable groups viz., Pseudomonas sp. and Halomonas sp. Culturable analysis reflected the dominance of Gammaproteobacteria as both nitrogen fixers and denitrifiers while other groups like Firmicutes and Alphaproteobacteria were very less represented among nitrogen fixers, and denitrifiers respectively. A total of 16 different genera were identified as nitrogen fixers and denitrifiers. BOX-PCR analysis of Mangovibacter, Vibrio, Bacillus and Catenococcus isolated in this study showed varied fingerprinting patterns compared to their respective positive controls reported earlier from this ecosystem, indicating they may be novel.
Study the impact of A nanomixture of carbon black and clay on the mechanical properties of A series of irradiated natural rubber/ butyl rubber blend
Authors: Alshangiti Dalal
Published: April 2021

A series of natural rubber/ butyl rubber NR/IIR blend loaded with N660 carbon black CB and triethoxy vinyl silane treated clay nano particles (TCNP) were prepared using gamma irradiation in the presence of polyfunctional monomer, trimethylolpropane triacrylate (TMPTA). The effect of incorporating different content of N660 carbon black and 5 part per hundred of rubber (phr) of treated clay on the mechanical properties of the prepared nano composites have been investigated. The additions of TCNP into CB/ rubber composites markedly increase their tensile strength due to the increase of the cross-link density. These results indicated that the TCNP may be enclosed or trapped in the occluded structure of CB. The effect of CB and TCNP content on the tensile strength (σ), elongation at break (εb %) and modulus of elasticity (E, MPa) of natural rubber/ butyl rubber NR/IIR blend have been investigated. The incorporation of 5 phr of TCNP into 30 phr carbon black loaded NR/ IIR composites results in the increased tensile strength value by about 60%. Finally, theoretical models were used to interpret the experimental results.
Wood carbon electrode in microbial fuel cell enhances chromium reduction and bioelectricity generation
Authors: Ni Hongyuhang , Khan Aman , Yang Zi , Gong Yuxin , Ali Gohar , Liu Pu , Chen Fengjuan , Li Xiangkai
Published: April 2021

Microbial Fuel Cell (MFC) remediate hexavalent chromium (Cr(VI)) in wastewater, but inefficient removal for wide scale. In this study, a wood carbon (WC) electrode was introduce in MFC to analyzed the Cr(VI) remediation mechanism and effect of WC on it. The results show that the Cr(VI) was completely removed with WC electrode as compare to the carbon cloth (31.12 ± 0.31%) and carbon felt (34.83% ± 0.12) within 48 hours. The maximum power density of the WC electrode was 62.59 ± 0.27 mW m− 2. Here in, WC might a good choice with a three-dimensional porous structure for Cr(VI) contaminated wastewater treatment and electricity generation in MFC.
Generation means analysis of traits related to lodging using two crosses of durum×emmer wheat
Authors: Mohammadi Majid , Mirlohi Aghafakhr , Majidi Mohammad Mahdi , Khedri Zahra , Rezaei Vahid
Published: April 2021

Lodging is one of the most important factors that affect wheat final yield. Emmer is a likely gene source to improve durum wheat; however, it is highly susceptible to lodging. The genetic studies of traits related to lodging in crosses of durum×emmer remains largely understudied. Here, we used progenies (six generations) derived from two crosses of durum×emmer in a generation means analysis (GMA) to determine gene action, inheritance, and genetic gain from selection in respect to plant height and its related traits. The results indicated that lodging resistance was significantly and negatively correlated with plant height and positively correlated with grain yield and mainly influenced by stem diameter. GMA results indicated that epistasis did not play an essential role in the genetic control of lodging related traits and almost the major portion of the genetic variation in these crosses resulted from additive gene actions. Also for all of the studied traits, the additive variance was higher than the dominance one. Narrow sense heritability was higher than 0.60 for most of the traits, and the genetic gain after one cycle of selection was positive for plant height and its components in both crosses. It was found that, selection in early generations may result in simultaneous reduction of plant height and increased stem diameter to improve lodging resistance in durum×emmer crossings.
Root K affinity drivers and photosynthetic characteristics in response to low potassium stress in K high-efficiency vegetable soybean
Authors: Liu Changkai , Wang Xue , Tu Bingjie , Li Yansheng , Chen Heng , Zhang Qiuying , Liu Xiaobing
Published: April 2021

Aims Vegetable soybean is highly demanded on potassium (K) application. Significant variations of K absorption and utilization exist in vegetable soybean. This study aim at exploring mechanisms of K absorption and utilization of high-efficiency in vegetable soybean by studying the characteristics of root K affinity-associated drivers and photosynthesis in vegetable soybean (edamame) (Glycine max (L.) Merr.).Methods Pot and hydroponic experiments were carried out to examine the characteristics of root K affinity-associated drivers and photosynthesis in vegetable soybean genotypes with different K efficiency. Two K high-efficiency vegetable soybean genotypes and two K low-efficiency genotypes were investigated in low K and normal K conditions. Results The root of K high-efficiency genotypes had a higher K+ affinity associated with higher maximum K+ uptake rate (Imax), but lower Michaelis constant for K+ absorption (Km) and lower compensation concentration for K+ uptake (Cmin). Seedlings of K high-efficiency genotypes also had higher root vigor (TTC reduction method) and greater absorbing activity (methylene blue method), especially in the low K condition. Besides, the root bleeding-sap rate per root length and K upward fluxes rate per root length of K high-efficiency genotypes in beginning seed stage were consistently higher than that of K low-efficiency genotypes. The root of K high-efficiency vegetable soybean genotypes exhibits K+ high-affinity and driving advantages. Photosynthetic parameters of K high-efficiency vegetable soybean genotypes were less affected by low K stress. Low K stress decreased the net photosynthetic rate of K high-efficiency genotypes by 6.1~6.9%, while that of K low-efficiency genotypes decreased by 10.9~15.7%. The higher Chl a/b ratio with enhanced relative content of Chl a in response to low K stress might be an adapted mechanism for K high-efficiency genotypes to maintain photosynthetic capacity.Conclusion Stronger root K affinity drivers associated with photosynthetic adaptability to low potassium stress are the key factors in determining the K high-efficiency of vegetable soybeans.
Assesment Of Protein Profile In Vitreus Samples Of Patients With Age-Related Macular Degeneration By Proteomic Approaches
Authors: Köse Hamza , Özkan Berna , Kanlı Aylin , Akpınar Gürler , Kasap Murat , Karabaş Levent
Published: April 2021

Background: To investigate the protein content in patients with age-related macular degeneration (AMD) with the aim of revealing the pathogenesis of the disease. Methods: Two groups were formed: 13 patients as the AMD group and 11 patients as the healthy control group. Vitreous samples were taken from both groups under sterile conditions and sent to the proteomics laboratory for proteomics analysis. In this study, we evaluated the proteome of vitreous samples of AMD and control groups using two-dimensional gel electrophoresis (2DE) coupled with MALDI-TOF/TOF.Results: We detected 11 proteins differentially regulated in the vitreous of AMD patients relative to healthy controls. The only protein that was up-regulated was Apolipoprotein E. We observed that Alpha 1-acid glycoprotein (AAG), Leucine-rich alpha-2-glycoprotein (LRG-1), Alpha-2-HS-glycoprotein, Haptoglobin, Alpha-Crystalline A Chain, Alpha- Crystalline B Chain, Immunoglobulin kappa constant, Beta-crystallin B2, Beta-crystallin A3, Beta-crystallin S levels were significantly decreased in patients with AMD. Conclusion: The detected proteins are related to biological regulation, retinal protection, and regulation of inflammation and angiogenesis processes. We believe that investigating these proteins will help to reveal the pathological mechanisms of AMD.
Knowledge and awareness regarding facemasks among medical professionals in a COVID dedicated hospital – Time for introspection and system strengthening.
Authors: Aggarwal Sulakshna , Bains Lovenish , Mishra Anurag , Dabaas Aashima , Goel Madhav , Perween Aiman Afsar
Published: April 2021

Background- There is a limited literature especially in India on the awareness regarding facemasks among medical professionals. Therefore the aim of the study is to assess the awareness, practices followed and problems faced in using different types of facemasks among medical professionals in a COVID dedicated hospital.Methodology- An e-survey via was conducted among medical professionals working in a tertiary care (COVID dedicated) hospital of North-India. The survey asked for the general demographic details, knowledge and awareness on facemask use, quality and various problems faced on regular or prolonged use, sanitization / disposal and recommendations to infected and non- infected people in community. Results- Survey was sent to around 368 medical professionals out of which a total of 150 participants completed the survey giving an overall response rate of 40.8%. The mean score was 9.8 +/- 2.375 out of 21 giving an overall correct rate of 46.67%. 38% and 31.33% participants knew the correct recommendations of facemasks to infected and non-infected people in the community respectively, Only 4.67% knew the correct sanitization procedures, 84% and 69.33% participants reported problems of discomfort on face and sweat issues respectively while 48.7% of the population felt some amount of breathlessness within 1-3 hours with N-95/FFP2 masks. Discussion- Awareness in this part of the world was low as compared to the western compared to countries (46.67%) which increases significantly with years of experience(p<0.001), however no such correlation of knowledge score with discipline of medical professionals was found. Since, it is the young medical force which is at the forefront to tackle the menace, therefore, institute should provide regular training and knowledge up gradation about the facemasks and adequate and accurate information needs to be disseminated to younger medical professionals via social media to prevent them from the risk of infection.
Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
Authors: Acharya Ananya , Kasaciunaite Kristina , Göse Martin , Kissling Vera , Guérois Raphaël , Seidel Ralf , Cejka Petr
Published: April 2021

The Dna2 helicase-nuclease functions in concert with the replication protein A (RPA) in DNA double-strand break repair. Using ensemble and single-molecule biochemistry, coupled with structure modeling, we demonstrate that the stimulation of S. cerevisiae Dna2 by RPA is not a simple consequence of Dna2 recruitment to single-stranded DNA. The large RPA subunit Rfa1 alone can promote the Dna2 nuclease activity, and we identified mutations in a helix embedded in the N-terminal domain of Rfa1 that specifically disrupt this capacity. The same RPA mutant is instead fully functional to recruit Dna2 and promote its helicase activity. Furthermore, we found residues located on the outside of the central DNA-binding OB-fold domain Rfa1-A, which are required to promote the Dna2 motor activity. Our experiments thus unexpectedly demonstrate that different domains of Rfa1 regulate Dna2 recruitment, and its nuclease and helicase activities. Consequently, the identified separation-of-function RPA variants are compromised to stimulate Dna2 in the processing of DNA breaks. The results explain phenotypes of replication-proficient but radiation-sensitive RPA mutants and illustrate the unprecedented functional interplay of RPA and Dna2.
Understanding the Factors that Affect the Appropriateness of Rheumatology Referrals
Authors: Broek-Altenburg Eline Van Den , Atherly Adam , Cheney Nick , Fama Teresa
Published: April 2021

Background: Reducing inappropriate referrals to specialists is a challenge for the healthcare system as it seeks to transition from volume to value-based healthcare. Given the projection of a severe shortage of rheumatologists in the near future, innovative strategies to decrease demand for rheumatology services may prove more fruitful than increasing the supply of rheumatologists. Efforts to increase appropriate utilization through reductions in capacity may have the unintended consequence of reducing appropriate care as well. This highlights the challenges in increasing the appropriate use of high cost services as the health system transitions to value based care. The objective of this study was to analyze factors affecting appropriateness of rheumatology services.Methods: This was a cross-sectional study of patients receiving Rheumatology services between November 2013 and October 2019. We used a proxy for “appropriateness”: whether or not there was any follow-up care after the first appointment. Results from regression analysis and physicians’ chart reviews were compared using an inter-rater reliability measure (kappa). Data was drawn from the EHR 2013-2019. Results: We found that inappropriate referrals increased 14.3% when a new rheumatologist was hired, which increased to 14.8% after wash-out period of 6 months; 15.7% after 12 months; 15.5% after 18 months and 16.7% after 18 months. Other factors influencing appropriateness of referrals included severity of disease, gender and insurance type, but not specialty of referring provider. Conclusions: Given the projection of a severe shortage of rheumatologists in the near future, innovative strategies to decrease demand for rheumatology services may prove more fruitful than increasing the supply of rheumatologists. Innovative strategies to decrease demand for rheumatology services may prove more fruitful than increasing the supply of rheumatologists. These findings may apply to other specialties as well. This study is relevant for health care systems that are implementing value-based payment models aimed at reducing inappropriate care.
Comparison of influenza surveillance systems in Australia, China, Malaysia and expert recommendations for influenza control
Authors: Guerche-Séblain Clotilde El , Fougerolles Thierry Rigoine De , Sampson Kim , Jennings Lance , Buynder Paul , Shu Yuelong , Sekawi Zamberi , Yee-Sin Leo , Walls Tony , Vitoux Olivier , Yin J. Kevin , Wong Ada , Schellevis Francois , Vanhems Philippe
Published: April 2021

Background: The Western Pacific Region (WPR) is exposed each year to seasonal influenza and is often the source of new influenza virus variants and novel pathogen emergence. National influenza surveillance systems play a critical role in detecting emerging viruses, monitoring influenza epidemics, improving public disease awareness and promoting pandemic preparedness, but vary widely across WPR countries. The aim of this study is to improve existing influenza surveillance systems by systematically comparing selected WPR influenza surveillance systems. Methods: Three national influenza surveillance systems with different levels of development (Australia, China and Malaysia) were compared and their adherence to World Health Organization (WHO) guidance was evaluated using a structured framework previously tested in several European countries consisting of seven surveillance sub-systems, 19 comparable outcomes and five evaluation criteria. Based on the results, experts from the Asia-Pacific Alliance for the Control of Influenza (APACI) issued recommendations for the improvement of existing surveillance systems. Results: Australia demonstrated the broadest scope of influenza surveillance followed by China and Malaysia. In Australia, surveillance tools covered all sub-systems. In China, surveillance did not cover non-medically attended respiratory events, primary care consultations, and excess mortality modelling. In Malaysia, surveillance consisted of primary care and hospital sentinel schemes. There were disparities between the countries across the 5 evaluation criteria, particularly regarding data granularity from health authorities, information on data representativeness, and data communication, especially the absence of publicly available influenza epidemiological reports in Malaysia. This dual approach describing the scope of surveillance and evaluating the adherence to WHO guidance enabled APACI experts to make a number of recommendations for each country that included but were not limited to introducing new surveillance tools, broadening the use of specific existing surveillance tools, collecting and sharing data on virus characteristics, developing immunization status registries, and improving public health communication.Conclusions: Influenza monitoring in Australia, China, and Malaysia could benefit from the expansion of existing surveillance sentinel schemes, the broadened use of laboratory confirmation and the introduction of excess-mortality modelling. The results from the evaluation can be used as a basis to support expert recommendations and to enhance influenza surveillance capabilities.