bluuebunny/crossref_metadata_2025 huggingface dataset:
Desarrollo de nanosistemas lipídicos para la liberación controlada de metalofármacos de platino(II) para el tratamiento de tumores colorrectales
Authors:   , Boztepe Tugce
Published: July 2023

Los complejos a base de platino son agentes quimioterapéuticos eficientes que han demostrado su actividad anticancerígena contra varios tipos de cáncer. Sin em-bargo, se deben considerar muchos desafíos para producir formulaciones derivadas de fármacos de platino novedosas y eficientes. La resistencia intrínseca o adquirida, la toxicidad limitante de la dosis, la degradación del fármaco, la baja solubilidad y, en consecuencia, la baja biodisponibilidad, se presentan como algunas de los aspectos que limitan las aplicaciones clínicas de los nuevos fármacos de platino. Estudios recientes muestran que ha habido un gran interés en desarrollar nuevas formulaciones de estos fármacos, para asegurar una mejor administración y ampliar el aspecto terapéutico. En este sentido, los nuevos avances en el desarrollo de vehículos para la administración de fármacos de platino ayudarán a aumentar su estabilidad y biodisponibilidad, junto con la reducción de su degradación y los efectos tóxicos secundarios indeseables que limitan su uso. En el presente trabajo de Tesis Doctoral se han desarrollado dos sistemas de libe-ración (pasivo y activo) para el 8-QO-Pt, que aparece como un prometedor complejo de platino con actividad antitumoral, a la vez que un interesante modelo de estudio para fármacos poco solubles en agua. El primer sistema fue diseñado en base al lípido de ésteres cetílicos (SS) con la presencia de dos aceites líquidos diferentes: triglicérido cáprico o aceite de oliva, para la liberación controlada y lenta en el colon que garantiza la biodistribución de las na-nopartículas como tales, al mismo tiempo que liberan su cargamento. Aunque este sis-tema no pudo mostrar una actividad antitumoral superior sobre el fármaco libre, sí mostró efectos anticancerígenos comparables a él, pero sin los efectos deletéreos que se le relacionan y con una actividad biocida mejorada sobre las células cancerosas. En el segundo sistema, la formulación con triglicéridos cápricos que demostró mejores efectos en el primer sistema, se funcionalizó con riboflavina para generar un sistema de sitio-dirección activo. En este estudio se han desarrollado e investigado por primera vez sistemas NLC con riboflavina dirigida a la liberación controlada de fár-macos. Los resultados son superiores a los sistemas anticancerígenos dirigidos a RFV publicados en literatura y a la acción del fármaco libre tanto en monocapa como en modelos 3D de cáncer colorrectal. Además, la formulación inhibió la migración celular de los esferoides multicelulares de colon, lo que demuestra que el sistema NLC con riboflavina dirigida evidenció también propiedades antimetastásicas.
O Percurso histórico das políticas de formação de professores da educação profissional: a regulamentação de caminhos alternativos
Authors: Valadares Lima Natália
Published: July 2023

O presente artigo objetiva problematizar as diretrizes para a formação de professores expressas por meio das legislações brasileiras ao longo da história da Rede Federal de Educação Profissional, Científica e Tecnológica. Para isso, realizamos uma retomada histórica dos dispositivos legais vigentes ao longo dos séculos XX e XXI. Problematizamos, também, os normativos legais vigentes atualmente, incluindo a Resolução CNE/CP n.º 1/2022, divulgada em maio de 2022. Metodologicamente, neste artigo pautamo-nos em uma detalhada análise documental, abarcando decretos, leis, regulamentos etc. que regem a Educação Profissional e Tecnológica em seus diferentes momentos históricos, em uma interlocução com estudos que visam analisar e problematizar aspectos referentes à formação docente e à educação profissional, guiando-nos pelos trabalhos de Machado (2008a, 2008b, 2014), Oliveira (2006, 2010), Costa (2018), dentre outros. Concluímos que a história da formação docente na educação profissional é marcada pelo estabelecimento de programas emergenciais, provisórios e aligeirados, sempre se colocando alternativas legais à exigência de formação em nível superior e em cursos de licenciatura. Os novos normativos, por seu turno, deixam ainda mais espaço para a instituição de formações alternativas aos docentes da educação profissional, precarizando tanto a profissão docente quanto o tipo de formação destinada aos trabalhadores.
Palavras-chave: Educação profissional. Formação docente. Legislação.
Pensamento Complexo e ensino: revisão sistemática de teses e dissertações no período de 2000 a 2020
Authors: Santos Andrade Ferreira Verena
Published: July 2023

Este artigo traz uma revisão sistemática de literatura, a partir das dissertações e teses selecionadas no Banco de Dados da Biblioteca Digital Brasileira, que trazem o Pensamento Complexo como aporte teórico e tratam de situações formais de ensino na Educação Básica. O objetivo é compreender como esse modo de conceber o conhecimento se apresentada nas pesquisas, uma vez que seu principal representante, Edgar Morin, defende que é necessária uma reforma do pensamento, do ensino e das instituições, acostumadas a fomentar a construção do conhecimento de forma linear, reducionista e fragmentada, como é próprio da Ciência Moderna. A partir dos filtros de pesquisa aplicados e dos critérios de inclusão e exclusão estabelecidos, chegamos a 25 trabalhos, cujos dados foram organizados através da Análise de Conteúdo, para responder às seguintes questões: quais os propósitos das investigações; qual a participação do marco teórico nas pesquisas e suas ideias predominantes; a que resultados chegaram. No esforço da redução que a categorização impõe e no reconhecimento das múltiplas relações que escapam à escrita, essa revisão traz as respostas às questões acima, cuja conclusão, de modo geral, revela a força do paradigma dominante e as possibilidades do paradigma emergente através das pesquisas estudadas.
Palavras-chave: Educação Básica. Ensino. Paradigma Emergente. Complexidade.
A educação alimentar e nutricional em cursos de Pedagogia do estado do Ceará: da formação acadêmica aos desafios de ensino por professores formadores
Authors: Moura Francisco Nunes de Sousa , Bezerra José Arimatea Barros , Leite Raquel Crosara Maia
Published: July 2023

Em virtude dos hábitos alimentares inadequados dos brasileiros e da necessidade de estudos sobre a formação de professores pedagogos para o ensino sobre assuntos de alimentação saudável, este trabalho objetivou analisar a formação acadêmica, as experiências exitosas e os desafios dos professores formadores de cinco cursos de Pedagogia do estado do Ceará sobre a realização de práticas educativas com o tema Educação Alimentar e Nutricional (EAN). Para isso, realizou-se a aplicação de um questionário eletrônico e/ou uma entrevista a sete docentes pedagogos que ministram disciplinas as quais tangenciam a EAN, como o Ensino de Ciências e a Educação em Saúde. Verificou-se que a maioria dos docentes dos cursos de Pedagogia investigados não teve formação com o tema alimentação saudável, as suas experiências se limitam aos aspectos assistencialistas, nutricionais e, em poucos casos, a perspectiva de vida dos sujeitos (cultural, social, ambiental, dentre outros). Quanto as dificuldades, detectou-se a carência de preparação acadêmica como majoritária, sendo reflexo de formações bacharelescas ou em áreas do conhecimento distintas do ensino de Ciências. Portanto, torna-se necessário investir na preparação desses docentes, os quais são essenciais para a formação inicial de futuros professores pedagogos.
Palavras-chave: Alimentação saudável. Professores formadores. Pedagogia.
O estado da arte da sequência de Perrin: uma análise dos aspectos evolutivos
Authors: Vieira Renata Passos Machado , Vieira Alves Francisco Regis , Machado Cruz Catarino Paula Maria
Published: July 2023

O presente artigo aborda um estado da arte para a sequência numérica recorrente de Perrin. Desse modo, é realizada uma análise dos trabalhos contidos nos últimos cinco anos, oriundos da base de dados do Google Acadêmico, tendo como objetivo da pesquisa um estudo em torno dos aspectos evolutivos da sequência de Perrin. Após a seleção e garimpagem dos trabalhos, são realizadas leituras para a composição do estado da arte desses números. Observa-se a ausência de investigações na área de ensino, permitindo uma contribuição e sugestão para trabalhos futuros. Além disso, a pesquisa permite um entendimento e conhecimento de como a sequência de Perrin está divulgada e estudada nos últimos anos.
Palavras-chave: Ensino. Estado da Arte. Sequência de Perrin.
The Explicit Teaching of Argumentation in the Approach of a Socio-Scientific Issue About the Use of Face Masks
Authors: Alves Luan Henrique , Araújo Letícia de Cássia Rodrigues , Miranda Ana Carolina Gomes , Mendonça Paula Cristina Cardoso
Published: July 2023

In this article, we present, as an educational product, a teaching sequence based on a socio-scientific issue about the use of face masks in the context of the Covid-19 pandemic, aimed at teaching science to II elementary level of compulsory education. The teaching sequence was formulated based on the following methodology – articulation of the conceptual, procedural, and attitudinal contents in the approach of socio-scientific issues (SSI) (NUNES-NETO; CONRADO, 2018) and the explicit teaching of argumentation (JIMÉNEZ-ALEIXANDRE, 2010). We highlight how the explicit teaching of argumentation can be promoted depending on the characteristics of the activities and the role of the teacher. We aim to provide subsidies to the science teacher on teaching actions involving the explicit teaching of argumentation that can be transferred to the teaching of other curriculum topics and other educational approaches. In addition, we argue that the approach of SSI, specifically because of its dialogic and controversial nature, promotes an effective formative space for the development of students' argumentative skills.
Keywords: Socio-scientific issues. Argumentation. Covid-19. Masks. Science teaching.
Percepções de docentes de ciências da natureza do Instituto Federal Farroupilha acerca do processo de avaliação
Authors: Griebler Gustavo , Castro Caurio Aline , Medina Sangbusch Bianca , Roehrs Rafael
Published: July 2023

Com o objetivo de refletir sobre a prática docente e sobre a aprendizagem escolar, traz-se o presente estudo que se deteve em entrevistar 23 docentes da área de Ciências da Natureza do Instituto Federal Farroupilha (IFFar). A referida pesquisa foi conduzida entre os meses de julho e setembro de 2020, época em que o desenvolvimento das atividades de ensino emergencial remoto estavam entrando em vigor. Neste aspecto, muitos foram os docentes que ainda estavam se acostumando ao trabalho com Tecnologias Digitais de Informação e Comunicação (TDICs), haja vista o distanciamento imposto pela pandemia da COVID-19. Para a geração de dados deste estudo de caso, foi estabelecido um roteiro de 26 perguntas que norteiam desde o tempo de trabalho em sala de aula, questões relativas à avaliação e a utilização das TDICs por parte dos docentes para sua realização das atividades escolares. A análise efetuada seguiu os preceitos de Bardin (2011), preceitos esses ancorados em três categorias em que os dados foram analisados, a saber: características do público, avaliação e prática do professor e tecnologias digitais e avaliação escolar. Sendo assim, a partir da análise dos dados, constatamos que os resultados mostraram docentes tradicionais no uso da avaliação, utilizando a prova como instrumento principal dentro do processo de ensino-aprendizagem. Contudo, observamos que novas metodologias e ferramentas passam a ser empregadas, em especial, pelo advento das TDICs.
Palavras-chave: Avaliação. TDICs. Ensino Remoto.
Um olhar atento e crítico para as estatísticas oficiais da educação profissional
Authors: Castro Soares de Oliveira Eilson , Carolina Soares Bertho Ana , Vasconcelos Nogueira Igor
Published: July 2023

O presente artigo tem como objetivo levantar elementos para a reflexão sobre as estatísticas oficiais da educação profissional, por meio do diálogo com produções de quatro autores que abordam diretamente esse tema: Cláudio de Moura Castro, Simon Schwartzman, Gustavo Henrique de Moraes e Ana Elizabeth de Albuquerque. Ainda que este trabalho não constitua uma robusta revisão de literatura, as análises fornecem subsídios para a reflexão, dadas as características, dificuldades e ausências de discussão das estatísticas relacionadas à educação profissional.  O presente estudo utilizou como princípio a sociologia das estatísticas oficiais. A análise permitiu destacar cinco elementos importantes para as estatísticas oficiais da educação profissional: a relação com as políticas públicas; a agenda de produção das estatísticas; as categorias analíticas; a verificação das tendências de dispersão ou centralização dos sistemas; e as ausências e invisibilidades contidas nos números.
Palavras-chave: Educação. Políticas públicas. Sociologia das estatísticas.
Multi-stakeholder partnerships for socio and laboral inclusion in Mexico: a literature review
Authors: Rodriguez Cotilla Montserrat , Barrón Villaverde Diana
Published: July 2023

In Mexico, 6 million people have a disability and only 38.5% in a working age have a job. The present literature review examines the main factors in companies for hiring and rejecting people with disabilities, as well as the main business initiatives that have been developed in favor of socio laboral inclusion in recent years in Mexico.

In our findings, we noticed differing opinions about not hiring people with disabilities, such as inexperience, fear of facing costs and legal matters. Multi-stakeholder partnerships in Mexico that promote hiring people with disabilities might be a channel for employment and information for business that intends to promote socio laboral inclusion in their companies.
Re-admisi rumah sakit pada penderita stroke: Sistematika Review
Authors: J. Siagian Heriviyatno
Published: July 2023

Latar belakang. Studi tentang faktor dan penyebab readmisi rumah sakit pada penderita stroke beresiko tinggi sangat sedikit. Tujuan dari penelitian ini adalah untuk menyelidiki penyebab umum dan pola rawat inap jangka pendek dan jangka panjang pasien stroke melalui kajian sistematis menggunakan data administrasi rumah sakit. Faktor risiko umum yang terkait dengan perubahan tingkat penerimaan kembali juga diperiksa.

Metode. Pencarian literatur dilakukan dari tanggal 15 Februari hingga 15 Maret 2016 menggunakan berbagai database, seperti Medline, Embase, dan Web of Science.

Hasil. sebanyak 24 studi (????=2.126.617) yang termasuk dalam kajian ini. Hanya 4 studi menilai penyebab rawat inap kembali pada pasien stroke dengan durasi tindak lanjut dari 30 hari sampai 5 tahun. Penyebab umum dari rawat inap kembali di sebagian besar penelitian adalah stroke berulang, infeksi, dan kondisi jantung. Faktor risiko terkait pasien umum yang terkait dengan peningkatan tingkat penerimaan kembali adalah usia dan riwayat penyakit jantung koroner, gagal jantung, penyakit ginjal, penyakit pernapasan, penyakit arteri perifer, dan diabetes. Di antara faktor-faktor yang berhubungan dengan stroke, lama rawat inap indeks stroke dikaitkan dengan peningkatan angka rawat inap, diikuti dengan inkontinensia usus, selang makanan, dan kateter urin.

Kesimpulan. Meskipun faktor risiko dan penyebab umum dari penerimaan kembali diidentifikasi, tidak ada penelitian sebelumnya yang menyelidiki penyebab dan urutan penerimaan kembali di antara pengguna stroke berdampak tinggi.
PENGARUH MEDIA LEAFLET TERHADAP PENGETAHUAN IBU TENTANG IMUNISASI DASAR
Authors: Herdhianta Dhimas , Assafa Muhammad Rifqi , Saleh Hesty Damayanti
Published: July 2023

Latar belakang: Anak dapat tumbuh dan berkembang secara optimal membutuhkan beberapa upaya untuk memenuhi kebutuhan dasarnya. Salah satu kebutuhan penting dari anak adalah imunisasi. Imunisasi merupakan upaya kesehatan masyarakat yang dapat mencegah penularan terhadap beberapa penyakit. Proporsi Imunisasi Dasar Lengkap pada Anak Umur 12-23 Bulan  di Provinsi Jawa Timur dikategorikan dengan cakupan Imunisasi lengkap sebesar 69.2%, Imunisasi Tidak Lengkap sebesar 26,3% dan Tidak Imunisasi sebesar 4,6%. Data di Kabupaten Pamekasan dengan imunisasi lengkap sebesar 37,5% dan imunisasi tidak lengkap sebesar 41,93%. Oleh karena itu, perlu adanya intervensi menggunakan media promosi kesehatan leaflet mengenai imunisasi dasar. Tujuan: Mengetahui pengaruh pemberian media edukasi leaflet terhadap pengetahuan ibu tentang imunisasi dasar.

Metode: Pengumpulan data dilakukan dengan pengisian kuesioner (pretest) selanjutnya pemberian edukasi menggunakan media leaflet sebanyak 2 kali intervensi. Selesai intervensi, diadakannya pengisian kuesioner kembali (posttest). Penelitian ini menggunakan rancangan one group pretest â€“ posttest kepada total sampel sebanyak 32 responden. Analisis data menggunakan Paired T-test dan uji Wilcoxon (data berdistribusi tidak normal) untuk membuktikan hipotesis penelitian.

Hasil: Persentase pengetahuan sebelum diberikan edukasi menggunakan leaflet sebesar 46,56%. Persentase pengetahuan sesudah diberikan edukasi menggunakan leaflet sebesar 69,84%. Selisih peningkatan pengetahuan sebesar 23,28%. Sedangkan persentase peningkatan pengetahuan sebesar 50%. Nilai p value sebelum dan sesudah diberikan edukasi dengan media leaflet sebesar (p=0,000).

Kesimpulan: Terdapat pengaruh pemberian media edukasi leaflet terhadap pengetahuan ibu tentang imunisasi dasar.
Game of Coefficients : Algebraic Cubic And Elliptic Curves
Authors: Bansal Abhishek
Published: July 2023

In this paper, an important novel study with interesting conclusions on algebraic cubic curves and elliptic curves is being presented. Various popular algebraic cubic curves and elliptic curves viz., Ochoa curve, Mordell curve, projection, birational transformation, Conchoid of de Sluze, Maltese cross curve, Semicubical Parabola, Tschirnhausen Cubic, Right Strophoid, Strophoid, have been studied. 

The paper has three novelties - different curves obtained by changing coefficients, the solutions in both  x  and y are given and the roots which are obtained from the algebraic curve equation,are again interpolated with different degrees viz., degree 2, 4, 6 and 10, with root mean square error.

 Many accomplished graduates, mathematicians or scientists, will question its need. But interesing results are found, which are given in the conclusion.
Psychologische behandeling van kinderen en jongeren met autisme
Authors: Peeters Wilfried
Published: July 2023

For some children and adolescents with autism psychological treatment can be indicated as part of a more comprehensive support plan. Communication breakdowns, motivational problems and differences in information processing make adaptations to the method and style of the therapist necessary. This article describes the specifics of such an autismspecific form of psychotherapy.
De ontwikkeling van een diagnose: zestig jaar autisme 1960-2020
Authors: van Berckelaer-Onnes Ina , Verkerk Dieuwke , Begeer Sander
Published: July 2023

This study provides insight into sixty years of autism diagnostics in the Netherlands. The historical changes in the period of 1960-2020 were investigated on the basis of seven factors, including the age of diagnosis, intelligence and type of diagnostician. The data are derived from participants (n = 2643) of the Dutch Autism Register (NAR: Nederlands Autisme Register), a longitudinal register, in which people with autism are followed over time. They were divided into cohorts based on the decade between 1960 and 2020 in which they were diagnosed. All participants whose birthday and age of diagnosis age were eligible for the study. The most important changes concern the age of diagnosis and the increase in the number of women with ASD. In addition, the concept of diagnosis has been broadened significantly. Autism is a classification of behavioural characteristics and is a part of a broad diagnostic process necessary for responsible counselling and treatment.
Authors: Ridwan Rahmat , Putra Randa Afri , Khairi Putri Mufidatul
Published: July 2023

Pada artikel yang penulis tulis ini memuat beberapa kajian mengenai Zakat sebagai Instrumen Fiskal. Secara sederhana zakat dapat diartikan sebagai kewajiban seseorang terhadap hartanya dan mencapai nisab yang kemudian diperuntukan untuk sekelompok orang. Sedangkan Instrumen berarti suatu alat. Dan kebijakan perihal penerimaan dan pengeluaran negara disebut kebijakan fiskal. Itu lah sedikit gambaran mengenai zakat, instrumen dan kebijakan fiskal. Dan Studi ini bertujuan untuk mengetahui bagaimana zakat bisa sebagai instrumen dalam kebijakan fiskal. Maka dari itu penulis memiliki tujuan untuk mengetahui dan memahami perihal zakat. Dan tidak hanya itu, pada artikel ini juga bertujuan untuk mengetahui dan menguraikan kebijakan fiskal.
ANALISIS PERBANDINGAN RASIO PROFITABILITAS SEKTOR FINANCIAL (PT. BANK SINARMAS TBK, PT. BANK OF INDIA INDONESIA TBK, PT. BANK VOCTORIA TBK) PERIODE 2012-2021
Authors: Laily Alvynada Nurul , Ariyanti Azhamita Nanda , Putri Dita Amalia , Jufri Achmad , Darmawan Darmawan
Published: July 2023

The purpose of this research is to analyze the comparison of financial performance in three banking companies, PT. Bank Sinarmas Tbk, PT. Bank Of India Indonesia Tbk, PT. Bank Victoria International Tbk based on profitability ratios in 2012 to 2022. This research was conducted using secondary data obtained from the collection of financial statements at the three bank companies from 2012 - 2021. The financial statements of the three banks were carried out in-depth analysis with Profitability Ratios using measurement of financial performance based on Net Profit Margin, Return On Equity, and Return On Assets. The research results obtained that the financial performance at PT. Bank Sinarmas Tbk, PT. Bank Of India Indonesia Tbk, PT. Bank Victoria Tbk based on the NPM, ROE and ROA ratios shows that the financial performance on the NPM ratio of Bank Victoria has a better and higher standard category level compared to other companies. For the ratio of ROE and ROA, Bank Sinarmas has a better standard because the fluctuations are more stable than Bank India Indonesia and Bank Victoria, which fluctuate each year.
الدور الاقليمي لكل من الجمهورية الاسلامية الايرانية والمملكة العربية السعودية واثره على منطقة الشرق الاوسط – رؤية استراتيجية معاصرة -
Authors: عبيس رشا , الفتلاوي صباح
Published: July 2023

من خلال العرض السابق للدور الإقليمي للجمهورية الإسلامية في إيران والسعودية التي تعد من أقوى الدول العربية من حيث امتلاك مصادر الطاقة في المنطقة وخاصة النفط ، وتأثير تداعيات هذا الدور والصراعات. في منطقة الشرق الأوسط ، ولحل المشكلة التي قدمها الباحثان بشكل جذري ، حل استراتيجي يتلخص في تشكيل تحالف رباعي بين دول (العراق ، إيران ، تركيا ، سوريا) ، على أساس الفلسفة التجريبية. (إن حل أي مشكلة تكمن في إفراغ محتواها) تشكيل الرباعية لتفريغ المشكلة من محتوياتها وتحويل رعاة الصراع في الأرض إلى فائض الكهرباء من الحاجة إلى الأرض دون الإضرار بالآخرين ، وبالتالي فهي ضرورية أن نلاحظ ما يلي لضمان تحقيق السلام والأمن والدور الفعال للقوى الإقليمية في منطقة الشرق الأوسط لقد وقفنا على الأدوار الإقليمية لجمهورية إيران الإسلامية والمملكة العربية السعودية في منطقة الشرق الأوسط. شرق. من خلال الاستقطاب الدولي والإقليمي الذي لعب دورًا رئيسيًا في تشكيل الرؤية الفعالة التي اقتضت إنشاء التحالف الرباعي المفترض لتجنيب المنطقة ويلات الحروب والصراعات.
PENGARUH ASET TIDAK BERWUJUD DAN KEPEMILIKAN PUBLIK TERHADAP NILAI PERUSAHAAN YANG TERDAFTAR DALAM INDEK LQ 45 PERIODE TAHUN 2016 – 2020
Authors: Kasman Kasman
Published: July 2023

This study aims to determine the effect of intangible assets and public ownership on the value of companies listed in the LQ 45 Index on the Indonesia Stock Exchange for the 2016-2020 period. The method of data collection in this study was indirect observation, only examining the object of research, namely manufacturing companies listed on the Indonesia Stock Exchange, precisely on the LQ 45 Index. Observations made by researchers were non-participant observations, where researchers made observations as data collectors without involving themselves. or become part of the observed environment. This study obtained empirical results that became evidence of the Effect of Intangible Assets and Public Ownership on the Value of Companies Listed in the LQ 45 Index for the Period of 2016 – 2020. Based on the analysis, it can be concluded that there is no simultaneous effect of Intangible Assets (X1) and Ownership. Public (X2) to Firm Value (Y). There is no partial significant effect of Intangible Assets (X1) on Firm Value (Y). There is no partial significant effect of Intangible Assets (X1) on Firm Value (Y).Keywords : Intangible Assets, Public Ownership, Company Value
PERAN EMAS SEBAGAI SAFE HAVEN UNTUK EIDO DAN IHSG PADA PERIODE SEBELUM DAN SELAMA PANDEMI COVID-19
Authors: Sugiyanto Kezia Viona , Robiyanto Robiyanto
Published: July 2023

Penelitian ini mengkaji potensi emas dapat berfungsi sebagai aset haven untuk EIDO dan IHSG. Penelitian ini bertujuan untuk menganalisis bagi para investor agar dapat memutuskan investasi yang menguntungkan dalam jangka waktu sebelum dan selama pandemi COVID-19, dan bagaimana peran emas dapat menjadi safe haven bagi EIDO dan IHSG. Data yang digunakan dalam penelitian ini adalah data sekunder dari indeks saham EIDO dan IHSG penutupan harian yang bersumber dari yahoo finance dan data harga emas penutupan harian di pasar internasional selama periode Januari 2018 – Desember 2021. Analisis data dilakukan dengan menggunakan QREG dan OLS untuk dapat melihat potensi emas dapat berfungsi sebagai safe haven. Hasil penelitian ini menunjukkan bahwa emas tidak dapat berperan sebagai safe haven bagi EIDO dan IHSG, namun emas dapat berperan sebagai diversifikasi bagi IHSG. Sehingga para investor disarankan ketika kondisi pasar modal sedang tidak mengalami kepastian, sebaiknya memilih alternatif lain selain emas sebagai bahan portofolio.
PENGARUH ENTREPRENEURIAL ATTITUDE, WORK ENGAGEMENT, EMPLOYEE ENGAGEMENT TERHADAP ORGANIZATIONAL COMMITMENT PADA PERUSAHAAN EKSPEDISI DI JAKARTA
Authors: Aleyda Fildzah , Emilisia Netania
Published: July 2023

Tujuan dari penelitian ini untuk menganalisis pengaruh entrepreneurial attitude, work engagement, employee engagement terhadap organizational commitment kepada karyawan perusahaan ekspedisi di Jakarta. Sampel yang digunakan pada penelitian ini yaitu purposive sampling kepada 150 responden dengan menyebarkan kuesioner. Metode analisis data yang digunakan adalah metode regresi sederhana dengan SPSS versi 25. Hasil menunjukkan bahwa entrepreneurial attitude, work engagement dan employee engagement berpengaruh positif. Temuan pada penelitian ini bermanfaat dalam memberikan informasi analisis pengaruh entrepreneurial attitude, work engagament dan employee engagament terhadap organizational commitment. Implikasi bagi perusahaan dapat meningkatkan commitment para pekerja dengan menciptakan sifat kewirausahaan dan memberikan rasa kepedulian, beri kesempatan berpendapat dan penghargaan sehingga timbul perasaan tertarik dan keterikatan pada perusahaan.
PENGARUH LITERASI KEUANGAN DAN INKLUSI KEUANGAN TERHADAP KINERJA UMKM SENTRA DODOL PENGLATAN
Authors: Widi I Made Widiawan , Sinarwati Ni Kadek
Published: July 2023

Riset ini merupakan riset yang bertujuan guna menggali pengaruh literasi dan inklusi keuangan terhadap kinerja UMKM. Tipe riset yang digunakan yakni riset kuantitatif yang informasinya bersumber dari data primer hasil penyebaran kuisioner serta data sekunder dari dokumen- dokumen yang telah tersedia terkait riset. Ilustrasi dalam riset ini yakni UMKM di Sentra Dodol Penglatan yang berjumlah sebanyak 49 pengusaha dan informasi riset diolah dengan SPSS 18. 0. Bersumber pada pengolahan informasi, diperoleh hasil kalau kedua variabel independen yang digunakan ialah literasi keuangan serta inklusi keuangan mempunyai pengaruh positif signifikan terhadap kinerja UMKM Sentra Dodol Penglatan.
PENGARUH RETURN ON ASSETS (ROA), TOTAL ASSETS TURNOVER (TATO), DAN VALUE ADDED INTELLECTUAL COEFFICIENT (VAIC™) TERHADAP NILAI PERUSAHAAN
Authors: Septiani Mira , Wulandari Endang
Published: July 2023

Tujuan penelitian ini untuk menganalisis bagaimana kinerja perusahaan sektor farmasi yang terdaftar di Bursa Efek Indonesia tahun 2015-2019 dalam hal pengembalian aset (ROA), perputaran total aset (TATO), dan koefisien nilai tambah intelektual (VAIC™) terhadap nilai perusahaan. Ini adalah praktik umum yang memanfaatkan purposive sampling untuk memperoleh data sekunder dalam penelitian. Regresi linier berganda kemudian digunakan untuk mengevaluasi data. Perputaran total aset (TATO) terbukti tidak memiliki pengaruh yang signifikan terhadap nilai perusahaan, sedangkan pengembalian aset (ROA) dan koefisien nilai tambah intelektual (VAICTM) keduanya memiliki pengaruh yang substansial. Ukuran sampel yang kecil, merupakan kelemahan penelitian ini. Peneliti merekomendasikan untuk memperpanjang durasi studi di masa depan untuk meningkatkan keandalan temuan mereka.
Pertanggungjawaban Agresi Militer Rusia Terhadap Ukraina Di Wilayah Donbass
Authors: Firmansyah Fikri Iman , Prakasa Satria Unggul Wicaksana
Published: July 2023

Rusia melancarkan agresi ke Ukraina serta mengadakan serbuan dari segala penjuru. Hal ini dianggap sebagai " Perang Putin" oleh semua negara. Salah satu bentuk pertanggungjawaban Rusia terhadap Ukraina akibat perbuatan agresi yakni harus reparasi atau pemulihan terhadap negara yang menjadi korban negara aggressor. Konflik ini belum diakui secara resmi sebagai kejahatan terhadap perdamaian internasional. Negara Ukraina dianggap sebagai korban agresi menurut hukum internasional meskipun agresi kepada Ukraina merupakan pelanggaran nyata terhadap piagam pbb serta statuta roma. Permasalahan utama yang akan dikaji ada dua : (1)Bagaimana pertanggungjawaban secara individu dan kolektif ( sebagai negara) terkait agresi ini.  (2) Mekanisme ajudikasi dan non ajudikasi dari kejahatan agresi yang dilakukan Rusia kepada Ukraina. Tujuan penelitian ini untuk mengetahui tindakan agresi militer Rusia terhadap Ukraina beserta implikasi hukum yang berlaku. Metode penelitian yang digunakan adalah Sosio-Legal. Untuk menuntut Putin dan para pemimpin politik dan militer Rusia lainnya di pengadilan kriminal internasional memiliki hambatan dari sisi hukum maupun politik. Pengadilan Kriminal Internasional tidak memiliki data terkait kejahatan agresi, serta penarikan diri Rusia dari Pengadilan Kriminal Internasional mampu mereduksi yurisdiksi ICC. Alternatif lain diupayakan yakni pengadilan ad hoc karena kejahatan agresi erat kaitannya dengan kejahatan terhadap kemanusiaan dan perang. Atau dengan dilakukannya praktik penerapan yurisdiksi universal untuk mengadili pelaku kejahatan agresi.
Access and Utilization of Maternal Newborn and Child Health Services in the Fragile Context of Somalia
Authors: Onama Victor , Babughirana Geoffrey
Published: July 2023

Background: The humanitarian situation in Somalia is characterized by unstable government, insecurity, fragility, and limited investments in funding essential public services and maternal newborn and health services are not spared. The health system in Somalia remained under-resourced to meet the urgent lifesaving, essential, and preventive health services. This study sought to assess the access and utilization of maternal and newborn child health services in Somalia.
Methodology: A cross-sectional design was used in this study. Descriptive and inferential statistical data analysis was conducted to establish the performance of indicators and relationships. The study targeted mothers of children 0-59 months.
Results: The results show a low (13.1%) attendance of focused (4th visit) antenatal care among the mothers. 23.3% of the mothers from Somaliland attended at least three antenatal care visits, while the rest of the states only achieved less than 10%. At least 41.5% of the deliveries occurred at the health facility. Skilled attendants assisted 42.7% of the deliveries. No significant difference was observed in the number of women having an extra meal during pregnancy or delivery at the health facility or in predicting the number of ANC visits. Nonetheless, 43.2% of the infants in Somalia had not been exclusively breastfed for the first six months of life. The results equally demonstrated poor nutritional index with only 38.4% of the pregnant women having an extra meal during pregnancy. In Somalia, early health care seeking for common childhood illnesses is still low, with Respiratory Tract infections (RTIs) at 40%, malaria at 56.6%, and diarrhea at 63.4%.
Conclusion and Recommendations: There is a need for deliberate efforts to improve low-performing indicators and hence improve the survival of mothers and children.
Pro-inflammatory activity of COPD macrophages in the in vitro experiment
Authors: Sugaylo I. Yu. , Naumov D. E. , Gassan D. A. , Kotova O. O. , Gorchakova Y. G.
Published: July 2023

Introduction. Chronic obstructive pulmonary disease (COPD) is a severe, progressive disease characterized by irreversible airway obstruction and emphysema. Prolonged exposition to airborne toxicants triggers irreversible processes leading to aberrant polarization of macrophages and defective phagocytosis, imbalance of pro- and anti-inflammatory cytokines. Aim. To study the features of the reaction of macrophages in COPD patients to the action of pro- and anti-inflammatory stimuli. Materials and methods. The study included 8 COPD patients and 6 control subjects. All persons underwent clinical and functional examination and sampling of peripheral venous blood for the isolation of monocytes. Cells had been cultured with 50 ng/mL granulocyte-macrophage colony-stimulating factor for 6 days, and then were polarized into pro-inflammatory (M1) and anti-inflammatory (M2) macrophages by adding E. coli lipopolysaccharides (LPS) 100 ng/mL and recombinant human interferon gamma (IFN-γ) 20 ng/ml, or interleukin 4 (IL-4) 20 ng/ml, respectively. Cytokine analysis was performed in the culture medium supernatant by multiplex analysis on a flow cytometer. Results. In the non-polarized state (M0), cells of COPD patients and the control group did not differ in the rate of cytokine production. At the same time, under LPS/IFN-γ stimulation a more pronounced increase in pro-inflammatory CXCL10 was observed in patients with COPD as compared with the control group (104.5-fold vs. 41.6-fold, p=0.04), and in the control group, on the contrary, the production of anti-inflammatory IL-10 was increased to a greater extent (99.6-fold vs. 30.5- fold, p=0.06). The effect of IL-4 on COPD macrophages was accompanied by a more pronounced decrease in IL-6, TNFα and IL-8 as compared to the group of healthy subjects. Conclusion. COPD macrophages are characterized by increased sensitivity to polarizing stimuli: under M1 stimulation we observed increased pro-inflammatory activity and under conditions of M2 differentiation, on the contrary, more pronounced inhibition of pro-inflammatory mediators occurred.
Comparative characteristics of the elemental composition of teenagers' biosamples depending on living conditions of the Khabarovsky Kray
Authors: Nesterenko A. O. , Evseeva G. P. , Tselikh E. D.
Published: July 2023

Introduction. The elemental status of an organism reflects the geochemical background of the habitat, including the imbalance of trace elements in the water and soil of a given region. We presented the results of studying the concentration of Fe, Сu, Mo, Zn, Co, Se, Th and U in the hair of teenagers with different living conditions of the Khabarovsky Kray. Aim. To analyze the level of influence of the elemental composition of drinking water and soil on the ecological portrait of teenagers living in different regions of the Khabarovsky Kray. Materials and methods. The analysis of trace elements in hair, soil and drinking water was carried out by means of inductively coupled plasma atomic emission spectroscopy. Results. Significant correlations were found between the concentration of Fe, Co, Mo, Th in hair and water (r=0.48-0.89), Fe, Cu, Zn, Se in hair and soil (r=0.38-0.71). The value of correlation relationships among children of Khabarovsk and the Nikolaevsky district is 1.5 times higher than among teenagers of the Okhotsky district. Conclusion. Thus, an imbalance of trace elements in the environment can affect health and be a risk factor for the development of environmentally related diseases.
EVALUATION OF PERFORMANCE BASED IMPAIRMENT OF STROKE PATIENTS
Authors: G. Velmurugan  , S. Viswanathan  , Milton J. Andrews , U. Niyamathulla
Published: July 2023

Background: Stroke is the leading cause of physical dysfunction. It is imperative to identify the current level of physical activities of stroke patients to plan for effective rehabilitation strategies. Aim of the study was to evaluate the severity of performance impairment of stroke patients using Fugl-Meyer Assessment and Total motor score. Methods: Thirty-seven stroke patients were selected. The performance impairment was evaluated by FMA motor score. Both upper limb (UL) and lower limb (LL) motor function was evaluated. The maximum UL score was 66 and LL score was 34. The relationship of age and duration of condition with FMA motor score was studied by Pearson’s correlation coefficients. The difference in the gender and type of stroke with the FMA motor score was analysed by MannWhitney ‘U’ test. Result: The mean FMA total score was 43.81 ± 7.12. The relationship between age and total motor score was not significant with, r = 0.004, p = 0.980. There was no significant relationship between duration of the condition and motor recovery, r = 0.46, p = 0.304 > 0.05. The difference in the gender (z = 0.55, p = 0.579) and type of stroke (z = 0.06, p = 0.956) was not significant with the total motor score. Conclusion: It is concluded that stroke patients have severe performance impairment evaluated by FMA and Total motor score. Motor recovery was not dependent on the age and gender of patients
A COMPARATIVE STUDY TO FIND THE EFFECTIVENESS OF SWISS BALL AND THERA BAND EXERCISE ON ABDOMINAL GIRTH AND QUALITY OF LIFE OF OBESE CHILDREN
Authors: K. Kamatchi  , S. Balaji  , James Binita Maria , Ritheeka.V  , Fathima K.A Asmath
Published: July 2023

Background of study: Obesity refers to a condition of having excessive amount of body fat. The WHO has described obesity as one of today’s most neglected public health problem, affecting every region of the country. The intra-abdominal fat carries a greater health risk than that stored elsewhere in the body. The study was attempted to compare the effectiveness of Swiss ball and Thera band exercise on abdominal girth and quality of life of obesity children. The objective of the study is to find the effectiveness of Swiss ball and Thera band exercise on abdominal girth and quality of life of obesity children. Methodology: This study is an experimental type design, comparative pre-post type. 30 children with obesity were selected and randomly divided into two groups. Children aged 8-12 and whose BMI values were 30-34.9 kg/m², children who had not continued a diet program for 3 months were included in the study. The children with any psychological conditions, or any other weight reduction plan, who cannot do exercise, above 12 and below 8 aged children were excluded in the study. The waist circumference, waist hip ratio and the pediatric quality of life inventory (Peds QL) was used as outcome measures. The study duration was up to 12 weeks. Result: Group A Swiss ball exercises showed marked improved than the Group B TheraBand exercises. Conclusion. The result of this study showed an improvement in reduction of abdominal girth of obese children.
СОЦИАЛЬНЫЕ СЕТИ В ПОЛИТИЧЕСКИХ КОММУНИКАЦИЯХ
Authors: Саралинова Д.С. , Юшаева Р.С-Э. , Магомедова Ф.Р.
Published: July 2023

Эффективное взаимодействие с гражданами является целью любого органа государственного управления. Современные достижения в области ИКТ позволяют устранить ограничения традиционных форм коммуникации (телевидение, средства массовой информации, официальные веб-сайты) на формат данных, скорость обратной связи и охват целевой аудитории. Поскольку граждане являются активными пользователями социальных сетей, эффективность этой формы общения выше, чем взаимодействия через отдельные веб-сайты. Государственные органы могут использовать информацию, получаемую из сете-вой системы, и агрегированные данные, полученные в результате мониторинга и анализа средств массовой информации, для принятия решений и разработки более обоснованных коммуникационных стратегий.
МЕХАНИЗМ УПРАВЛЕНИЯ СИСТЕМОЙ ОБРАЗОВАНИЯ
Authors: Чажаев М.И. , Чажаева А.М.
Published: July 2023

Государство утверждает, что основой развития общества по всем направлениям – социальному, политическому, экономическому, духовному и культурному – является образование. Оно должно управляться надлежащим образом, поскольку является государственным и общественным институтом и работает на благо общества и государства. Система образования выполняет важнейшие функции социальной системы и действует как самоорганизующийся механизм. Она влияет на развитие общества, а также на передачу культуры, ценностей, социального опыта и информации. В связи с установленной взаимосвязью между уровнем образования и производительностью труда инвестиции в образование становятся все более значимыми в качестве движущей силы социального и экономического успеха. Традиционная модель образования, поощряющая легкое усвоение и повторение материала, должна быть изменена на модель, поддерживающую целостный рост и учитывающую индивидуальные потребности, когда образование рассматривается как товар, а не как общественная или социальная цель. Однако, поскольку образование является самоорганизующейся системой, оно может приспосабливаться к постоянным изменениям и решать новые проблемы.
ВЛИЯНИЕ ЦИФРОВЫХ ТЕХНОЛОГИЙ НА ФОРМИРОВАНИЕ БИЗНЕС-ПРОЦЕССОВ ПРЕДПРИЯТИЙ ПИЩЕВОЙ ПРОМЫШЛЕННОСТИ
Authors: Гехаева П.Т.
Published: July 2023

В статье исследуются актуальные вопросы формирования бизнес-процессов на предприятиях и повышения их эффективности путем применения современных цифровых технологий. Проанализирована специфика цифровых технологий, которые применяются в практической деятельности предприятий как в нашей стране, так и за рубежом для улучшения качества продукции, повышения эффективности технологических и логистических процессов, а также сокращения сроков вывода продукции на рынок. Определена результативность внедрения цифровых технологий в отдельные бизнес-процессы. Сформирован перечень бизнес-процессов, которые характерны для предприятий промышленности, с учетом структуры жизненного цикла продовольственных товаров, и очерчена совокупность тех процессов, которые подлежат наиболее значимому влиянию цифровых технологий.
ГОСУДАРСТВЕННОЕ СТИМУЛИРОВАНИЕ ИННОВАЦИОННОЙ ДЕЯТЕЛЬНОСТИ
Authors: Довлетмурзаева М.А.
Published: July 2023

В работе дана характеристика методов государственной поддержки и стимулирования инновационной деятельности. Актуальность темы исследования обусловлена тем, что в современной России за последнее время было реализовано большое количество мероприятий, направленных на повышение инновационной активности коммерческих предприятий, при этом правительству не уда-лось значительно увеличить объемы технологий, которые проходят полный цикл создания от идеи до массового производства на территории РФ. В государствах с достаточно развитой рыночной экономикой в последние годы наблюдается возникновение так называемой «корпоративной культуры», ориентированной на развитие и внедрение инноваций. В данной культуре воплощено взаимное стремление субъектов социально-экономических отношений к получению доступа к источникам информации и свободному ее обмену.
KONTRIBUSI PENGAWASAN ORANG TUA DALAM KONTEKS GAME ONLINE PADA ANAK
Authors: Hidayat Rahmad , Nurhayati Nurhayati
Published: July 2023

ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan mengenai peran orang tua dalam memberikan pengawasan kepada anak saat bermain game online di desa Nambahrejo Kec. Kotagajah, Lampung Tengah. Metode yang digunakan adalah deskriptif dengan pendekatan kuantitatif. Sampel pada penelitian ini berjumlah 28 responden. Hasil penelitian menunjukkan bahwa orang tua berperan dalam mengawasi anaknya ketika bermain game online meskipun belum maksimal, hal ini dikarenkaan orang tua yang tidak memiliki banyak waktu dirumah dan menghabiskan waktu dengan anak, peran orang tua ini yang dimaksud meliputi 60,71% memberikan arahan dalam bermain game online, 78,58% memberikan batasan anak dalam bermain game online, 64,29% bermain game bersama dengan orang tua yang secara tidak langsung mengawasi mereka. ABSTRACTThis study aims to describe the role of parents in providing supervision to children when playing online games in Nambahrejo Village, Kec. Kotagajah, Central Lampung. The method used is descriptive with a quantitative approach. The sample in this study amounted to 28 respondents. The results of the study show that parents play a role in supervising their children when playing online games even though they are not optimal, this is because parents do not have much time at home and spend time with children, the role of these parents includes 60.71% giving directions in playing online games, 78.58% give limits for children to play online games, 64.29% play games together with parents who indirectly supervise them.
DAMPAK PROGRAM KAMPUNG BANTAR TERHADAP PERILAKU MASYARAKAT KOTA JAMBI
Authors: Darmuji Darmuji , Hasanah Khuswatun
Published: July 2023

ABSTRAKMasalah kebersihan dan keamanan adalah masalah yang sering terjadi di daerah. Berbagai upaya telah dilakukan pemerintah daerah untuk mengatasi maupun mencegah permasalahan tersebut. Pemberian otonomi daerah yang seluas-luasnya kepada daerah mengakibatkan munculnya paradigma daya saing daerah dimana para kepala daerah berlomba-lomba untuk mewujudkan kesejahteraan masyarakat dengan cara kepemimpinan yang berbeda-beda sesuai dengan khas dari daerah tersebut. Salah satu upaya kepala daerah untuk menerapkan kebersihan dan keamanan adalah membuat program Kampung BANTAR (Bersih, Aman, dan Pintar).  Adapun tujuan penelitian ini yaitu untuk mengetahui dampak program kampung BANTAR terhadap perilaku masyarakat Kota. Metode yang digunakan dalam penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Berdasarkan hasil observasi dan wawancara yang peneliti lakukan bahwa dengan adanya program kampung BANTAR di Rt. 45 Kelurahan Jelutung telah memberikan dampak positif berupa perubahan lingkungan yang lebih baik seperti pekarangan rumah yang lebih rapi, serta menumbuhkan kembali semangat gotong royong, serta masyarakat setempat telah meluangkan waktu di taman bacaan yang disebut dengan pojok baca.  ABSTRACTHygiene and safety issues are frequent problems in the area. Various efforts have been made by local governments to overcome or prevent these problems. The granting of the widest possible regional autonomy to the regions has resulted in the emergence of a regional competitiveness paradigm in which regional heads compete to realize the welfare of the community by means of different leadership according to the characteristics of the region. One of the regional head's efforts to implement cleanliness and security is to create a PANTAR (Clean, Safe, and Smart) Village program. The purpose of this study is to determine the impact of the PANTAR village program on the behavior of the people of the city. The method used in this research is descriptive research with a qualitative approach. Based on the results of observations and interviews conducted by researchers that the existence of the BATAR village program on Rt. 45 Jelutung Village has had a positive impact in the form of changes to the environment for the better such as a neater house yard, as well as regenerating the spirit of mutual cooperation, and the local community has spent time in a reading garden called a reading corner.