bluuebunny/crossref_metadata_2025 huggingface dataset:
Geçici Koruma Altındaki Suriyelilerin Türkiye Ekonomisine Etkisi: Denizli Örneği
Authors: ÖZPENÇE Özay , ÇELİK Emine
Published: August 2021

Mart 2011’de Suriye’de meydana gelen savaş neticesinde ülkelerini terk edip komşu ülkelere sığınan Suriyelilerin en çok tercih ettiği ülkelerden biri de Türkiye’dir. Savaşın uzun süre devam etmesinin de etkisiyle ülkemizde hızla artan Suriyeli sayısı sosyal, siyasal, ekonomik ve kültürel olarak birçok açıdan ülkemizi etkilemiştir. Bu çalışmamızda tekstil şehri olarak bilinen Denizli iline sığınan geçici koruma altındaki Suriyelilerin Denizli’ye etkileri ekonomik yönden analiz edilmiştir. Çalışmamızın sonucunda, Suriyelilerin olumsuz vergi algısına neden olduğu ortaya çıkmıştır. Bununla beraber kamu harcamalarını, kayıt dışılığı ve işsizliği artırdığı sonucuna ulaşılmıştır. Ayrıca kadınların ve eğitim seviyesi yüksek olan katılımcıların Geçici Koruma Altındaki Suriyelilerin çalışma hayatına katılımlarını daha çok destekledikleri tespit edilmiştir.
Mixing ARMA Models with EGARCH Models and Using it in Modeling and Analyzing the Time Series of Temperature
Authors: Ali Mudhir Abduljabbar
Published: August 2021

In this article our goal is mixing ARMA models with EGARCH models and composing a mixed model ARMA(R,M)-EGARCH(Q,P) with two steps, the first step includes modeling the data series by using EGARCH model alone interspersed with steps of detecting the heteroscedasticity effect and estimating  the model's parameters and check the adequacy of the model. Also we are predicting the conditional variance and verifying it's convergence to the unconditional variance value. The second step includes mixing ARMA with EGARCH and using the mixed (composite) model in modeling time series data and predict future values then asses the prediction ability of the proposed model by using prediction error criterions.
Student Support at Unisa: A Flowing-River Metaphor
Authors: Mokwena Gladys
Published: August 2021

The flowing-river metaphor is explored in this paper for the Unisa Department of Adult Education’s higher certificate programme student support. It is a qualitative case study, grounded in Connectivism. It involves seven lecturers’ reflections of using the elements of the flowing-river metaphor on the way in which technology has reorganised lecturers’ interactions when providing support to students in teaching and learning. Virtual talking circles on the Microsoft Teams forum, a review of departmental reports on student support, and my reflection on the experiences of higher certificate lecturers when providing student support in teaching the module material are the main data gathering tools. The flowing-river metaphor, on the other hand, uses the contrast between vehicle and target to help higher certificate students to develop their teaching and learning. In this case, the complexity of using available resources varies from lecturer to lecturer. The paper encourages other higher education lecturers to think more carefully about the flowing-river metaphor’s potential as a pedagogical guide for student support.
Pigmented transverse nasal band: A review
Authors: Agarwal Komal , Podder Indrashis , Sarkar Rashmi
Published: August 2021

Pigmented transverse nasal band/groove is an asymptomatic benign condition, characterized by the development of erythematous to hyperpigmented, well-demarcated, transverse groove at the junction of middle and lower two-third of the nasal dorsum. Although the pathogenesis is unclear, embryologic origin seems to be the most plausible hypothesis. This condition is often associated other related dermatological conditions such as milia, comedones, seborrheic dermatitis and atopic dermatitis. Diagnosis is mostly clinical, while reassurance is the mainstay of therapy. In persistent cases, topical retinoids have been used. In this article, we have reviewed the different aspects of this condition including treatment, along with the recent updates to create awareness about this dermatological entity.
Incidence of complications after the surgical removal of impacted mandibular third molars: A single center retrospective study
Authors: Prerana G , Tantry Deepa , Sougata Kumar , Sivalanka Sree Chandana Shreya
Published: August 2021

Objectives:

The aim of the study was to study the incidence of complications associated with the surgical removal of impacted mandibular third molars in a single center.

Material and Methods:

A single center retrospective study was conducted in the Department of Oral and Maxillofacial Surgery at NSVK Sri Venkateshwara Dental College and Hospital located in Bannerughatta, Bengaluru. The study included patients between the ages of 15–60 years who had undergone surgical extraction of one or more mandibular third molar and had a difficulty score between 3 and 6 (Pederson’s difficulty index). During the course of study variables such as age, gender, impacted side, difficulty index, medical, and habit history along with complications and medications were recorded and accessed from the patient’s case history reports. In due course of the study, these variables were analyzed and correlated using descriptive analysis, Chi-square test, Contingency test, and regression analysis to understand whether or not these variables play an important role in aggravating post-extraction complications for mandibular third molars.

Results:

The study sample was composed of 250 patients with 52% female and 48% male with a mean age of 34 years. The complication rate observed was 7.6%, there was a statistically significant co-relation seen between gender (P = 0.016), age groups (p<0.05), spatial relationship (P = 0.019), and medical history (P = 0.016) when compared to the complications observed. The most common complications observed were trismus/muscle spasm followed by dry socket. However, the cases of neurosensory complications were extremely rare.

Conclusion:

There was a significant association to be found between the complication-rate and gender. Conditions such as muscle spasms/trismus and dry socket had a significant predilection toward the males while complications associated with neurosensory changes were commonly seen in females. There was also a significant association between habit history and rate of complication especially in conditions such as dry-socket where all the observed cases had positive history of tobacco/pan chewing habit. Interestingly all the males who complained of dry socket also had reported medical history of type (2) diabetes. Patients with complications such as neurosensory changes were few and could have been prevented with good surgical skills and precision; moreover, even if they were found they were temporary and treated with regular follow-ups.
Regional blockade for prolonged anesthesia in enucleation and evisceration
Authors:   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of Health of the Russian Federation, Irkutsk, Oleshchenko I.G. , Mishchenko О.P. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of Health of the Russian Federation, Irkutsk, Gasparyan М.А. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of Health of the Russian Federation, Irkutsk
Published: August 2021

Regional anesthesia is widely used in ophthalmology both as an independent method and in combination. Retrobulbar anesthesia has risks of complications and is undesirable in the surgical treatment of choroidal melanoma due to the risk of metastasis of tumor cells when it is performed. Therefore, it is necessary to search for alternative methods of regional blockades in order to create prolonged anesthesia. Purpose. To develop and evaluate the clinical efficacy of pterygopalatine blockade as a component of combined method of anesthesia for evisceration or enucleation of the eyeball. Methods. A comparative analysis of the effectiveness of intraoperative anesthesia and the course of postoperative period was carried out in patients of two clinical groups formed depending on the method of anesthesia. Results. Intraoperative monitoring of hemodynamics in the groups did not differ. The nature of pain in the patients of the compared groups in the postoperative period had significant differences in presence and intensity of pain on the scale of verbal sensations. Discussion. Use of pterygopalatine blockade with levobupivacaine in combination with dexamethasone as an adjuvant allows getting a prolonged analgesic, anti-inflammatory and decongestant effect. This makes it possible to avoid the use of opioid analgesics in the early postoperative period, that is, to avoid such systemic side effects as nausea, dizziness, and in rare cases vomiting, which generally improves the quality of the postoperative period. Conclusions. Use of pterygopalatine ganglion blockade with local prolonged-acting anesthetic levobupivacaine and dexamethasone as an adjuvant based on inhaled anesthesia with sevoflurane provides safe and effective anesthesia in patients with evisceration or enucleation of the eyeball, both in the intra- and postoperative period. Key words: enucleation; evisceration; pterygopalatine blockade; dexamethasone.
The incidence of dry eye syndrome depending on the duration of antihypertensive drops use in patients with primary open-angle glaucoma
Authors:   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Pilipenko A.D. , Burya R.A. ,   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Romanova A.V. ,   The Khabarovsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk
Published: August 2021

Aim. To conduct a clinical assessment of the incidence of dry eye syndrome (DES) in patients with primary open-angle glaucoma (POAG), depending on the timing of the use of local antihypertensive therapy. Methods. The main group included 45 patients (45 eyes) with POAG. Inclusion criteria - use of local antihypertensive therapy for at least one month; absence of previous laser and microsurgery operations, systemic pathology that can cause DES (thyroid lesions, diabetes mellitus, autoimmune and rheumatoid diseases). The patients’ age averaged 61.2±8.7 years (from 47 to 82 years). There were 29 men and 16 women. The design of the work consisted of a comparative assessment of the frequency of DES formation in the studied groups and subgroups, as well as the degree of its severity. Results. The results of the study showed that with an increase in the duration of the use of local antihypertensive drugs by patients with POAG the incidence of DES development increases. Moderate changes in the studied functional parameters of the ocular surface were recorded as early as 1-3 years from the start of antihypertensive therapy. Especially often DES was formed in the 3rd subgroup and proceeded in more severe clinical forms. Conclusion. The initial statistically insignificant changes in the indicators of the state of the ocular surface in patients with POAG using local antihypertensive therapy took place at the time of their instillation from 1 to 3 years. Most often, according to our data, DES developed in patients with POAG after three years of using antihypertensive drugs (9 out of 15 patients). Key words: dry eye syndrome; glaucoma; antihypertensive therapy.
Formation of retinal pigment epithelium rupture in a patient with wet form of macular degeneration against the background of anti-vegf therapy
Authors:   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation, Irkutsk, Yakimov A.P. ,   Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk, Kuzmin S.V. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation, Irkutsk
Published: August 2021

Purpose. To present possible complications of anti-VEGF therapy in patients with high pigment epithelial detachment on the basis of a clinical case. Methods. A clinical case of pigment epithelium rupture formation in a patient on the background of anti-VEGF therapy with aflibercept. Results. The presented clinical case clearly demonstrates the significance of OCT-signs of high risk of pigment epithelium rupture formation. The question of anti-VEGF therapy continuation in case of detection of these signs in a patient with continued activity of the process, as well as the choice of the drug, remains open. Key words: wet macular degeneration; pigment epithelium detachment; pigment epithelium rupture; aflibircept; ranibizumab.
FIELDS OF SPECIFIC HEAT CAPACITY OF SUPERCRITICAL WATER FLOWING IN CHANNELS
Authors:   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Fialko Nataliia , Prokopov Viktor ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Meranova Nataliia ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Aleshko Sergey ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Polozenko Nina ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Kutnyak Olha ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Khmil Dmytro ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Sharaievskyi Ihor ,   Institute of NPP Safety Problems of NAS of Ukraine, Zimin Leonid ,   Institute of NPP Safety Problems of NAS of Ukraine, Vlasenko Tetiana ,   Institute of NPP Safety Problems of NAS of Ukraine
Published: August 2021

The data of CFD analysis of the specific heat capacity fields of supercritical water in round channels at different values of the heat flux supplied to the wall are presented.
METHODS FOR PROTECTING BOILER CHIMNEYS AGAINST CORROSION DUE TO FALL-OUT CONDENSATE FROM FLUE GASES
Authors:   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Fialko Nataliia , Navrodska Raisa ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Gnedash Georgii ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Presich Georgii ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Shevchuk Svitlana ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine
Published: August 2021

The application of thermal methods for protection of chimneys of boiler units with deep heat-recovery systems of exhaust-gases was proposed. The results of the research have confirmed the high efficiency of these methods.
IMPROVEMENT OF COMPLEX HEAT-RECOVERY SYSTEMS FOR GAS-FIRED BOILER UNITS
Authors:   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Fialko Nataliia , Navrodska Raisa ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Gnedash Georgii ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Shevchuk Svitlana ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine, Sbrodova Galina ,   Institute of Engineering Thermophysics of National Academy of Sciences of Ukraine
Published: August 2021

The calculation and analysis of the complex heat-recovery system for heating by warmth of exhaust-gases from a boiler unit several heattransfer agents for the needs of the boiler house, namely, return heat-network water, combustion air and raw water for chemical water-purification system have been carried out. Results of researches have confirmed high efficiency of the offered technical solution.
Single nucleotide polymorphism rs1128446 ТXNRD1 is a novel genetic marker of cerebral stroke
Authors: Бушуева О.Ю. , Полоников А.В. , Иванов В.П.
Published: August 2021

Мозговой инсульт (МИ) занимает третье место в структуре смертности во всем мире и является ведущим фактором снижения когнитивных функций и деменции. Окислительный стресс является ведущим механизмом повреждения головного мозга при ишемии и последующей реперфузии. Тиоредоксиновая система является наиболее важным антиоксидантным барьером клетки, способным регулировать ее окислительно-восстановительный статус. Целью исследования было изучение ассоциации однонуклеотидного полиморфизма rs1128446 гена эндогенного регулятора тиоредоксина ТXNRD1 с риском развития МИ. Материалом для исследования послужила выборка неродственных жителей Центральной России общей численностью 825 человек. В исследование были включены 375 пациентов с МИ (216 мужчин, 159 женщин; средний возраст 59,44±0,51 лет). Контрольную группу составили 450 относительно здоровых индивидуумов (249 мужчин, 201 женщина, средний возраст 61,69±0,38 лет) без кардио- и цереброваскулярных заболеваний в анамнезе и имеющих нормальный уровень артериального давления. Генотипирование SNP проводили методом ПЦР в режиме реального времени путем дискриминации аллелей с помощью TaqMan-зондов. Для анализа ассоциаций генотипов с развитием заболевания пользовались лог-аддитивной регрессионной моделью. Все расчеты выполнены относительно минорного аллеля; введены поправки на пол и возраст. SNP rs1128446 ТXNRD1 был связан с повышенным риском развития МИ (OR=1,89; 95% CI=1,48-2,43; p<0,0001). Проведенный биоинформатический анализ выявил высокий регуляторный потенциал данного SNP в тканях сердечно-сосудистой системы. Таким образом, впервые установлена ассоциация rs1128446 ТXNRD1 с развитием МИ.

Cerebral stroke (CS) is the leading factor in cognitive decline and dementia and ranks third in the structure of mortality worldwide. Oxidative stress is the basic mechanism of brain damage after cerebral ischemia-reperfusion. The thioredoxin system is the most important antioxidant barrier of the cell, capable of regulating its redox status. The aim of this study was to investigate the association of the common single nucleotide polymorphism rs1128446 in gene encoding the endogenous thioredoxin regulator TXNRD1 with the risk of CS. A total of 825 unrelated individuals from Central Russia were included for this study: 375 patients with CS (216 males, 159 females; 59.44±0.51 years old) and 450 healthy controls (249 males, 201 females, 61.69±0.38 years old). Genotyping was performed using TaqMan-based PCR. To analyze the associations of genotypes with the risk of diseases, a log-additive regression model was used. All calculations were performed relative to the minor allele; corrections for gender and age have been introduced. SNP rs1128446 TXNRD1 was associated with an increased risk of CS (OR=1.89; 95% CI=1.48-2.43; P<0.0001). Bioinformatic analysis revealed a high regulatory potential of this SNP in tissues of the cardiovascular system. Thus, for the first time, the association of rs1128446 TXNRD1 with the development of CS was revealed.
The interpretation of somatic genetic variants identified with high-throughput sequencing of DNA from paediatric solid tumors
Authors: Спектор М.А. , Ясько Л.А. , Друй А.Е.
Published: August 2021

Активное внедрение высокопроизводительного секвенирования в клиническую практику требует общего подхода к интерпретации обнаруженных генетических вариантов, в частности, вариантов с соматическим статусом. В 2017 году Ассоциация молекулярной патологии США (AMP), Американская коллегия медицинской генетики и геномики (ACMG), Американское общество клинической онкологии (ASCO) и Коллегия американских патологов (CAP) опубликовали руководство по интерпретации соматических генетических вариантов и выдаче заключений по результатам высокопроизводительного секвенирования опухолевой ДНК. Данный обзор посвящен специфике применения руководства AMP/ACMG/ASCO/CAP для интерпретации результатов генетических исследований детских солидных опухолей. В статье приводятся критерии, на которых основана классификация соматических генетических вариантов, обсуждаются проблемы оценки клинической значимости генетических находок и приводятся примеры классификации генетических вариантов, выявленных в различных типах детских солидных опухолей.

Active clinical implementation of high-throughput DNA sequencing requires a common approach to the interpretation of detected genetic variants, including variants with somatic status. In 2017, the United States Association of Molecular Pathology (AMP), the American College of Medical Genetics and Genomics (ACMG), the American Society of Clinical Oncology (ASCO), and the College of American Pathologists (CAP) published the guidelines for interpreting and reporting the somatic genetic variants in cancer identified using high-throughput sequencing analysis. This review focuses on the specific application of the AMP/ACMG/ASCO/CAP guidelines in the field of genetic research on paediatric solid tumors. In particular, the review provides the criteria for classification of somatic genetic variants, discusses the problems of evaluating the clinical significance of genetic findings in paediatric tumors, and provides examples of classification of genetic variants specific for certain types of childhood solid malignancies.
Development of an approach to knockdown of DUX4 gene by siRNA in myoblasts derived from patients with FSHD
Authors: Кривошеева И. А. , Вяхирева Ю. В. , Табаков В. Ю. , Скоблов М. Ю.
Published: August 2021

Миодистрофия Ландузи-Дежерина (МЛД) - распространённое наследственное заболевание, вызываемое эктопической экспрессией гена DUX4 в мышечных клетках. Метод подавления экспрессии генов при помощи siРНК зарекомендовал себя как эффективный и безопасный способ генной терапии без вмешательства непосредственно в геном. В данной работе мы продемонстрировали возможность трансфекции миобластов человека целевыми siРНК без ущерба жизнеспособности и дальнейшей дифференцировке этих клеток в миотубы. Также мы показали различия в профиле экспрессии генов-мишеней DUX4 между миобластами, полученными от здоровых людей и от пациентов с МЛД. В дальнейшем эти данные могут помочь при разработке эффективных и специфичных siРНК для терапии МЛД.

Facioscapulohumeral dystrophy (FSHD) is a common hereditary disease caused by ectopic expression of the DUX4 gene in muscle cells. The method of suppressing gene expression using siRNA has been shown to be an effective and safe method of gene therapy without interfering directly with the genome. In this work, we demonstrated the possibility of transfecting human myoblasts with targeted siRNAs without compromising the viability and further differentiation of these cells into myotubes. We also showed differences in the expression profile of DUX4 target genes between healthy and patient-derived myoblasts. In the future, these data can be used to develop effective and specific siRNAs for the treatment of FSHD.
Pathophysiological rationale of the use of microRNA in cardioand oncological diagnostics (review)
Authors: Калинкин М.Н. , Щеглова Н.Е.
Published: August 2021

Многочисленные попытки изучить и доказать генетическую природу большинства заболеваний привели к открытию новых маркеров, в роли которых выступает класс так называемых «малых рибонуклеиновых кислот (РНК)» или микроРНК. В настоящем обзоре обсуждаются молекулярные механизмы сердечно-сосудистых и опухолевых заболеваний с участием микроРНК для возможного их использования в качестве диагностических и терапевтических мишеней.

Numerous attempts to study and prove the genetic nature of most diseases have led to the discovery of new markers, which are the class of so-called “small ribonucleic acids (RNA)” or microRNA. This review discusses the molecular mechanisms of cardiovascular and tumor diseases involving microRNAs and explores their possible use as diagnostic and therapeutic targets.
On solvability of a nonlinear system of equations for the Fourier-Chebyshev coefficients in the problem of solving ordinary differential equations using Chebyshev series
Authors: Арушанян О.Б. , Залеткин С.Ф.
Published: August 2021

Сформулирована и доказана теорема о разрешимости нелинейной системы уравнений относительно приближенных значений коэффициентов Фурье-Чебышёва. Теорема является теоретическим обоснованием ранее предложенного численно-аналитического метода интегрирования обыкновенных дифференциальных уравнений с использованием рядов Чебышёва.

A solvability theorem for a nonlinear system of equations with respect to approximate values of Fourier-Chebyshev coefficients is formulated and proved. This theorem is a theoretical substantiation for the previously proposed numerical-analytical method of solving ordinary differential equations using Chebyshev series.
A variant of the collocation method for the Fredholm integral equations of the second kind
Authors: Соловьева С.А.
Published: August 2021

Предложен и теоретически обоснован специальный вариант метода коллокации на базе полиномов Бернштейна приближенного решения интегральных уравнений Фредгольма второго рода в пространстве гладких функций.

A special variant of the collocation method based on Bernstein polynomials is proposed and theoretically substantiated for the approximate solution of Fredholm integral equations of the second kind in the space of smooth functions.
Scalability study of FlowVision on the cluster with Angara interconnect
Authors: Акимов В.С. , Силаев Д.П. , Симонов А.С. , Семенов А.С.
Published: August 2021

Исследуется масштабируемость вычислений задач газодинамики в программном комплексе FlowVision на кластере Ангара-К1 с интерконнектом Ангара. Рассматривались несколько тестовых задач, имеющих 260 тысяч, 5.5 млн и 26.8 млн расчетных ячеек. Вычисления во FlowVision проводились с использованием нового решателя систем линейных алгебраических уравнений, основанного на алгебраическом многосеточном методе AMG (Algebraic MultiGrid). Показано, что специальная технология FlowVision ``Динамическая балансировка'' позволяет существенно увеличить производительность вычислений, если особенности постановки расчетной задачи способствуют неравномерности загрузки процессоров. Кластер Ангара-К1 продемонстрировал отличные характеристики производительности и масштабируемости вычислений, не уступающие аналогам с интерконнектом 4х FDR Infiniband.

The scalability of computations in FlowVision CFD software on the Angara-C1 cluster equipped with Angara interconnect is studied. Several test problems with 260 thousand, 5.5 million and 26.8 million computational cells are considered. Computations in FlowVision are performed using a new solver of linear systems based on the algebraic multigrid (AMG) method. It is shown that the special FlowVision's technology named "Dynamic balancing" significantly improves the performance of computations if the peculiarities of the problem promote the non-uniform loading of CPUs. The Angara-C1 cluster demonstrates the excellent performance and scalability characteristics comparable with its analogues based on the 4х FDR Infiniband interconnect.
On some statements of nonlinear parabolic problems with boundary conditions of the first kind and on methods of their approximate solution
Authors: Гольдман Н.Л.
Published: August 2021

Исследованы две постановки в классах Гельдера нелинейных задач для параболического уравнения с неизвестным коэффициентом при производной по времени. Одна постановка представляет собой систему, состоящую из краевой задачи с граничными условиями первого рода и из уравнения,задающего закон изменения по времени искомого коэффициента. В другой постановке требуется, кроме того, определить и граничную функцию в одном из краевых условий по дополнительной информации об этом коэффициенте, заданной в конечный момент времени. Для этих постановок обосновано построение приближенных решений на основе метода Ротэ и метода квазирешений.

We study two statements of nonlinear problems in H\"{o}lder spaces for a parabolic equation with an unknown coefficient at the time derivative and the boundary conditions of the first kind. One statement is a system containing a boundary value problem and an equation for the time dependence of the sought coefficient. In the other statement, in addition it is necessary to determine a boundary function in one of the boundary conditions by using an additional information on this coefficient at a final time. For these statements we justify a construction of approximate solutions on the basis of the Rothe method and the method of quasisolutions.
Artificial boundary conditions for the ILES modeling of plane channel flow using the Cabaret scheme
Authors: Асфандияров Д.Г.
Published: August 2021

Представлены результаты ILES-моделирования классической задачи течения вязкой несжимаемой жидкости в плоском канале по схеме Кабаре. Рассматривается возможность модификации расчета течения возле стенки для более точного определения средних характеристик. Предложено введение "искусственных" граничных условий путем использования в первом слое ячеек вблизи стенки специальной модели вихревой вязкости для корректного учета сдвиговых эффектов. Приводится сравнение результатов расчета течения в плоском канале по схеме Кабаре с предложенными искусственными граничными условиями и без в широком диапазоне чисел Рейнольдса. Показано, что введенные модификации в пристеночном слое позволяют повысить точность определения средних характеристик течения, в особенности вторых моментов. Полученные данные также сравниваются с результатами LES-моделирования с использованием псевдоспектрального метода и с данными прямого численного моделирования.

Some results of ILES modeling of the plane channel flow of a viscous incompressible fluid using the Cabaret scheme are discussed. The possibility of modifying the calculation of flow near the wall is considered to determine the average
characteristics more accurately. The "artificial" boundary conditions are introduced by using a special eddy viscosity model in the first layer of cells near the wall to correctly account for shear effects. The results of numerical simulation of plane channel flow obtained using the Cabaret scheme with and without artificial boundary conditions are compared in a wide range of Reynolds numbers. It is shown that the introduced modifications in the near-wall layer improve the accuracy of determining the average flow characteristics, especially the second moments. The obtained data are also compared with the results of LES modeling by the pseudospectral method and with the data from direct numerical simulation.
Inverse problems of experimental data interpretation in 3D ultrasound tomography
Authors: Гончарский А.В. , Кубышкин В.А. , Романов С.Ю. , Серёжников С.Ю.
Published: August 2021

Обратная задача 3D ультразвуковой томографии рассматривается в статье как нелинейная коэффициентная обратная задача для уравнения гиперболического типа. Используемая математическая модель хорошо описывает как дифракционные эффекты, так и поглощение ультразвука в неоднородной среде. В рассматриваемой постановке реконструируется скорость распространения акустической волны как функция трех координат. Количество неизвестных в нелинейной обратной задаче составляет порядка 50 миллионов. Разработанные итерационные алгоритмы решения обратной задачи ориентированы на использование GPUкластеров. Основным результатом работы является апробация алгоритмов на экспериментальных данных. В эксперименте использовался стенд для 3D ультразвуковых томографических исследований, разработанный в МГУ имени М.В. Ломоносова. Акустические параметры фантомов близки к акустическим параметрам мягких тканей человека. Объем экспериментальных данных составляет порядка 3 ГБ. Интерпретация данных эксперимента позволила не только продемонстрировать эффективность разработанных алгоритмов, но и подтвердила адекватность математической модели реальности. Для реализации разработанных численных алгоритмов использовался графический кластер суперкомпьютера Ломоносов-2.

The inverse problem of 3D ultrasound tomography is considered in this paper as a nonlinear coefficient inverse problem for a hyperbolic equation. The employed mathematical model accurately describes the effects of ultrasound wave diffraction and absorption in inhomogeneous media. The velocity of acoustic waves inside the test sample is reconstructed as an unknown function of three spatial coordinates. The number of unknowns in the nonlinear inverse problem reaches 50 million. The developed iterative algorithms for solving the inverse problem are designed for GPU clusters. The main result of this study is testing the developed algorithms on experimental data. The experiments were carried out using a 3D ultrasound tomographic setup developed at Lomonosov Moscow State University. Acoustic properties of the test samples were close to those of human soft tissues. The volume of data collected in experiments is up to 3 GB. Experimental results show the efficiency of the proposed algorithms and confirm that the mathematical model is adequate to reality. The proposed algorithms were tested on the GPU partition of Lomonosov2 supercomputer.
On the approximation error in the problems of conjugate convective heat transfer
Authors: Мартыненко С.И.
Published: August 2021

Рассмотрено влияние малых возмущений границы области на погрешность аппроксимации модельной краевой задачи. Показано, что игнорирование малых возмущений границы приводит к дополнительной погрешности аппроксимации исходной дифференциальной задачи, не связанной с шагом сетки. Полученные результаты представляют интерес для математического моделирования сопряженного теплообмена, моделирования течений с поверхностными химическими реакциями и других приложений, связанных с течениями рабочих сред вблизи шероховатых поверхностей.

The effects of small boundary perturbation on the approximation error for a model boundary value problem are considered. It is shown that the ignorance of small perturbations of the boundary leads to an additional approximation error in the original differential problem. This error is independent of mesh size. The obtained results are of interest for the mathematical modeling of conjugate heat transfer, the modeling of flows with surface chemical reactions and other applications related to fluid flows near rough surfaces.
Relación de la gestión de riesgos y calidad de software realizados por los profesionales del Colegio de Ingenieros del Perú del Consejo Departamental de Lima
Authors: Paucar Bernardo Diana Valeria , Acho Santillan Paulina Tessalia , Peralta Delgado Carlos Salvador
Published: August 2021

Un factor crítico de éxito en la gestión de proyectos de tecnologías de información es la gestión de riesgos, y parte de determinar un proyecto como exitoso es lograr la calidad de software. En ese contexto, la investigación se basa en el propósito de contribuir de cierta manera en la gestión del proyecto para lograr el éxito, a través de una gestión de riesgos adecuada basada en un estándar reconocido. El objetivo de la investigación es determinar el grado de relación entre la gestión de riesgo y la calidad de software en proyectos realizados por los profesionales del Colegio de Ingenieros del Perú, Consejo Departamental Lima. El estudio es de diseño no experimental y de tipo correlacional, se realizó una encuesta virtual, en la cual se consideró aspectos como: aplicación de procesos de gestión de riesgo, planificación financiera, motivación del equipo de trabajo, capacitaciones y atributos de calidad del sistema de los proyectos que realizaron los encuestados. Los resultados indican que la gestión de riesgo tiene una relación significativa en la calidad de software, por lo que realizar una gestión de riesgos adecuado en proyectos asegura lograr los resultados esperados y a la vez, a cumplir con las características de calidad.
Wound healing potential of Launaea pinnatiϔida Cass leaf juice in rats
Authors: Kamala K. Chandak  , Dipak D. Wasule
Published: August 2021

Launaea pinnatifida is a procumbent herb native to the coastal area and found throughout India and many other countries. It is utilized as a dietary plant in the preparation of various dishes in the Maldives. Traditionally it is used for the treatment of skin injuries and is reported to contain flavonoids, steroids, glycosides, tannins, saponins etc. As no scientific work has been found to be published related to wound healing potential of the L. pinnatifida plant, the present study investigated the effects of dried leaf juice of L. pinnatifida on wound healing property in rats using various wound models. In result analysis, the wound contraction percentage was found to be increased and the scar area and epithelization time were found to be decreased when 3 % ointment L. pinnatifida leaf juice was applied topically. Similarly, with incision and dead space wound models, wound breaking strength and hydroxyproline levels were found to be increased. So, Launaea pinnatifida leaf juice showed significant wound healing activity in all wound models, which supports its claim for being used traditionally in skin diseases.
Metodologías en investigaciones sobre producción de textos narrativos con niños
Authors: Castro Diana
Published: August 2021

El artículo presenta una revisión de diferentes propuestas metodológicas en investigaciones sobre producción textual con niños, con un énfasis en los textos narrativos. Las características de los diseños metodológicos permiten reconocer distintas tensiones que le exigen al investigador posicionarse frente a un conjunto de posibilidades para plantear una actividad de escritura. Posterior a esta revisión, se presenta la metodología de la investigación desarrollada sobre escritura colaborativa entre niños en el computador y los análisis realizados a esta metodología. De este modo, el texto contribuye con la reflexión sobre las metodologías de trabajo con niños, los estudios sobre producción textual y las prácticas de escritura en diferentes entornos, entre ellos el escolar.
Cartas ao mar... De experiências que nos habitam: Narrativas de formação docente
Authors: HenriquesÂ  Eda Maria de Oliveira , Azevedo Mônica Maria de
Published: August 2021

Este trabalho pretende, através de um relato parcial de seu desenvolvimento e resultados, discutir e analisar a importância das narrativas de formação de professores no âmbito da pesquisa educacional. Nessa perspectiva, a pesquisa aqui relatada foi realizada em uma escola da rede pública de ensino do DF, Brasília, que atende o segmento do ensino fundamental de primeiro ao quinto ano e buscou identificar e analisar concepções de professores de ensino básico sobre suas experiências de leitura ao longo de sua trajetória escolar, bem como compreender a existência ou não de um diálogo destas com suas práticas pedagógicas atuais no ensino de leitura. Nessa direção, utilizou-se um enfoque de pesquisa baseado em narrativas de formação e escritas de si através de temas e propostas relacionados aos objetivos da pesquisa. Uma dessas propostas consistiu num pedido aos professores que escrevessem uma carta a professores que tenham sido, de alguma forma, marcantes no que diz respeito ao ensino e Ã  aprendizagem da leitura. Nesta perspectiva, para ampliarmos essa discussão, traremos a contribuição de Benjamin, que vai aprofundar as relações entre experiência e narrativa, e de Vygotsky e Bakhtin, que compreendem a linguagem como organizadora do pensamento e planejadora da ação, permitindo um distanciamento dos acontecimentos imediatos e da nossa própria vida. O fato dos professores terem privilegiado situações não diretamente relacionadas a processos de ensino e aprendizagem da leitura, mas a aspectos da relação professor e aluno, pode indicar que para estes docentes tais relações parecem ter um maior peso nas suas trajetórias de formação.
Metodologia qualitativa de pesquisa sobre a produção de sentidos intergeracional em comunidades rurais e quilombolas: entrevistas narrativas e argumentações
Authors: Santos Júlio César dos , Ramos Patrícia Campos
Published: August 2021

A articulação de diferentes métodos possibilita narrativas que perfazem as interpretações de si nas transições. A construção de explicações de si, nas narrativas, possibilita a identificação de mudanças de posicionamentos dos antepassados Ã s gerações seguintes. Utilizamos como instrumentos as entrevistas: (a) de história de vida; (b) episódica; (c) semiestruturada, mediada por fotografias/objetos. Realizamos as análises temática, pragmática do discurso e a produção de sentidos. Observamos processos de negociação de conflitos de si com os outros, como também de si consigo mesmo. Concluímos que diferentes métodos colaboram para a identificação da produção de sentidos intergeracional.
A fala egocêntrica utilizada pela criança em atividade escolar de escrita
Authors: Cavaton Maria Fernanda Farah
Published: August 2021

Objetivamos pesquisar a fala egocêntrica utilizada por quatro crianças de seis anos ao soletrar em atividades de escrita livre.  A função auto organizadora dessa fala está embasada na teoria vigotiskiana que discute a relação pensamento e fala. Numa abordagem quali-quanti de pesquisa, analisamos três sessões individuais com cada criança gravadas em vídeo, anotando a frequência de uso dessa fala e analisando cada processo de escrita. Os resultados mostraram a construção da escrita como um processo mediado pela relação escrita e fala egocêntrica. Duas crianças falaram mais e produziram mais, sendo as demais, uma já alfabetizada e outra pouco produziu. A fala egocêntrica de repetir sons de letras favorece a consciência fonêmica e a busca na memória da palavra a ser escrita. Portanto, as falas desempenham funções importantes em atividades escolares.
Editorial Linhas Críticas V.24
Authors: Souza Rodrigo Matos de
Published: August 2021

Editorial v.24
Menos pode ser mais: do decrescimento e descomplexificação à complexidade
Authors: Díaz José Eduardo García , Watanabe Giselle
Published: August 2021

Nos últimos tempos há um discurso reducionista que vem ganhando espaço em diversas publicações, conferências e debates amplos sobre o decrescimento e colapso associado aos limites biofísicos do meio que, por sua vez, levariam ao esgotamento de recursos naturais e às mudanças climáticas. Nessas abordagens é comum a defesa de que o decrescimento supõe uma descomplexificação desejada e/ou inevitável do sistema social. Esses pressupostos podem disseminar uma ideia equivocada sobre a forma de lidar com as questões socioambientais ao mesmo tempo em que aponta para limitações estruturais do ponto de vista social. Diante dessa problemática iminente, neste ensaio discutem-se alguns aspectos da perspectiva da complexidade partindo do pressuposto de que ela nos ajuda a compreender que o decrescimento não significa inevitavelmente uma diminuição da complexidade do sistema social. E nos mostra como uma formação mais criativa e crítica demandará intervenções que levem a uma proposta menos linear, pautada em uma mudança de paradigma e na própria forma de se relacionar socialmente.
BERRO! Uma educação transviada em química
Authors: Xavier Allan Moreira
Published: August 2021

Pode a química, e seu ensino, permitir-se enviadecer? A partir de uma prática de pesquisa-escrita, este ensaio propõe-se a discutir aspectos epistemológicos característicos da química, a possibilidade de uma produção rizomática deste saber e as consequências das desestabilizações produzidas pelo pensamento queer no discurso da química. Sugere uma educação pelo cu, a partir da qual serão liberadas as potências micropolíticas ativas, envolvidas em produções de monstros que nos direcionarão a explorar as potências de viver em devir.
Ensaio sobre as relações entre Educação, Ciência e Sociedade a partir da perspectiva do desenvolvimento humano
Authors: Camillo Juliano , Mattos Cristiano Rodrigues de
Published: August 2021

A noção de “relevância da ciência” é nosso objeto no presente ensaio. Fazemos a proposição de que a partir dela pode-se compreender as particulares conceitualizações acerca das interconexões entre educação, ciência e sociedade. Partindo de tal princípio, ensaiamos com quatro formas de relevância: “Ciência, consolidação institucional e domínio da natureza”; “Ciência e participação”; “Ciência, uma forma a mais de conhecer o mundo, porém perigosa”; e “Ciência e Desenvolvimento Humano”. As três primeiras, apesar de relativamente autônomas, constituem-se de um prelúdio para quarta, na medida em que explicitam algumas das mais difundidas concepções (e seus problemas associados) acerca das relações entre educação, ciência e sociedade. Na última parte, a questão da relação entre ciência e desenvolvimento humano é tomada a partir de uma perspectiva ontológica.
meu pé de laranja-lima
Authors: Corrêa Jordana , Oliveira Neiva Afonso
Published: August 2021

Este artigo visa discutir aspectos dos romances de formação (Bildungsromane) a partir da análise das obras autobiográficas de José Mauro de Vasconcelos (1920-1984): Doidão (1963), O meu pé de laranja lima (1968) e Vamos aquecer o sol (1974). Buscamos como aliadas teóricas algumas comentadoras do tema interdisciplinar que se calca na Filosofia e na Literatura e que embasa nossas investigações, como Barbara Freitag, Cristina Pinto e Wilma Patrícia Maas. As três obras de Vasconcelos podem ser consideradas romances de formação a partir da perspectiva de que os conceitos estão em constante movimento, fazendo com que novas características integrem-se ao formato dos Bildungsromane do século XXI.
Ciência, Educação e Sociedade (apresentação)
Authors: Watanabe Graciella , Gurgel Ivã
Published: August 2021

Apresentação
Levantamento Preliminar na seleção de Questões Sociocientíficas: o exemplo do areial em Olivença/BA
Authors: Santos Valéria Bonfim , Assunção Josenilda , Bomfim Manuela Gomes , Arcanjo Jeruza Rocha Lima , Gehlen Simoni Tormohlen
Published: August 2021

Estudos têm evidenciado um significativo crescimento de trabalhos da área da Educação em Ciências que utilizam Questões Sociocientíficas (QSCs), principalmente para elaboração de propostas didático-pedagógicas, porém, nem sempre explicitam os critérios para a escolha dessas QSCs a serem trabalhadas em sala de aula. Assim, investigam-se critérios de escolha das QSCs tendo como parâmetro aspectos do Levantamento Preliminar ”“ primeira etapa da Investigação Temática (Freire, 1987) ”“. O estudo foi desenvolvido no contexto de processo de formação de professores, tendo como referência a Investigação Temática, realizado em uma escola localizada no distrito de Olivença, município de Ilhéus/BA. As informações foram obtidas mediante blogs, sites de notícias da região e de conversas informais com moradores da comunidade de Olivença, e a análise foi realizada por meio da Análise Textual Discursiva com foco na categoria “o papel do Levantamento Preliminar na seleção de QSCs”. Dentre os resultados obtidos, destaca-se, que por meio das etapas do Levantamento Preliminar, identificou-se a controvérsia Areial, relacionada com a extração de areia no distrito de Olivença e que apresenta características das QSCs. Constatou-se que o Levantamento Preliminar pode ser um dos critérios de seleção e legitimação de uma QSC referente a uma questão local, em que a discussão pode ser ampliada para contextos globais. Essa QSC, ao ser trabalhada em sala de aula, pode contribui para uma ação social responsável dos educandos de uma comunidade localizada no município de Ilhéus/BA.
Controvérsias sócio-científicas e relações de poder: desafios de sua inserção segundo futuros professores de ciências
Authors: Watanabe Graciella , Reis Pedro Guilherme Rocha dos
Published: August 2021

A pesquisa em educação em ciências expôs a dificuldade na implementação de controvérsias sócio-científicas em sala de aula, particularmente em relação à infraestrutura e à formação de professores para lidar com atividades que vão além dos conceitos científicos. Vários fatores desestimulam os professores atuais e futuros a trabalharem na educação básica (fundamental e secundária) quando enfrentam o desafio de incluir tópicos não consensuais em suas aulas de ciências. Tendo em conta a situação política brasileira, esta pesquisa ilustra como os futuros professores compreendem suas ações e desafios, ao implementar controvérsias sócio-científicas. No contexto, apresentamos uma fração do trabalho desenvolvido no projeto “We Act”, no qual pretendíamos pesquisar as percepções das relações de poder através das interpretações de Pierre Bourdieu e Paulo Freire. As concepções dos participantes sobre as relações de poder nas escolas, e como práticas políticas, surgem como particularmente relevantes para o que chamamos de “vigilância da profissão docente”. Consequentemente, deve-se reconhecer que o contexto escolar é construído por influências sociais maiores do que a escola e a comunidade a que pertence.