bluuebunny/crossref_metadata_2025 huggingface dataset:
Fracture toughness of a hybrid rubber modified epoxy. II. Effect of loading rate
Authors: Abadyan M. , Kouchakzadeh M. A. , Bagheri R.
Published: January 2012

Effect of loading rate on toughness characteristics of hybrid rubber‐modified epoxy was investigated. Epoxy was modified by amine‐terminated butadiene acrylonitrile (ATBN) and recycled tire. Samples were tested at various loading rates of 1–1000 mm/min. Fracture toughness measurements revealed synergistic toughening in hybrid system at low loading rates (1–10 mm/min); hybrid system exhibited higher fracture toughness value in comparison with the ATBN‐modified resin with same modifier content. However, synergistic toughening was eliminated by increasing the loading rate. At higher loading rates (10–1000), the fracture toughness of hybrid system decreased gradually to the level lower than that of ATBN‐modified epoxy. Fractography of the damage zones showed the toughening mechanisms of ATBN‐modified system was less affected by increasing the loading rate compared to that of hybrid system. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Biochemical investigation and gene analysis of equol: A plant and soy‐derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications
Authors: Gopaul Remona , Knaggs Helen E. , Lephart Edwin D.
Published: January 2012

The purpose of this study was to investigate the effects of equol, a plant and intestinal flora derived isoflavonoid molecule on the expression of skin genes and proteins using human dermal models. As equol has been shown to mimic 17β‐estradiol and bind specifically to 5α‐dihydrotestostone (5α‐DHT), these agents were used (in addition to equol) to determine whether equol may play important and beneficial roles in the extracellular matrix (ECM). Equol at 0.3 or 1.2% in qPCR experiments using a human skin barrier model examined ECM gene expression. Equol, 5α‐DHT, and 17β‐estradiol at 10 nM were studied in human monolayer fibroblasts cultures (hMFC) for ECM protein expression. Human fibroblast three‐dimensional organotypic cultures revealed equol's influence (@ 10 nM) on ECM proteins via fluorescent‐activated cell sorting (FACS) analysis. In qPCR experiments, equol significantly increased collagen, elastin (ELN), and tissue inhibitor of metalloprotease and decreased metalloproteinases (MMPs) gene expression and caused significant positive changes in skin antioxidant and antiaging genes. In hMFC, equol significantly increased collagen type I (COL1A1), whereas, 5α‐DHT significantly decreased cell viability that was blocked by equol. FACS analysis showed equol and 17β‐estradiol significantly stimulated COL1A1, collagen type III (COL3A1), and ELN while MMPs were significantly decreased compared with control values. Finally, tamoxifen blocked the positive influences of equol on ECM proteins via FACS analysis. These findings suggest that equol has the potential to be used topically for the treatment and prevention of skin aging, by enhancing ECM components in human skin.
Rotating algal biofilm reactor and spool harvester for wastewater treatment with biofuels by‐products
Authors: Christenson Logan B. , Sims Ronald C.
Published: January 2012

Maximizing algae production in a wastewater treatment process can aid in the reduction of soluble nitrogen and phosphorus concentrations in the wastewater. If harvested, the algae‐based biomass offers the added benefit as feedstock for the production of biofuels and bioproducts. However, difficulties in harvesting, concentrating, and dewatering the algae‐based biomass have limited the development of an economically feasible treatment and production process. When algae‐based biomass is grown as a surface attached biofilm as opposed to a suspended culture, the biomass is naturally concentrated and more easily harvested. This can lead to less expensive removal of the biomass from wastewater, and less expensive downstream processing in the production of biofuels and bioproducts. In this study, a novel rotating algal biofilm reactor (RABR) was designed, built, and tested at bench (8 L), medium (535 L), and pilot (8,000 L) scales. The RABR was designed to operate in the photoautotrophic conditions of open tertiary wastewater treatment, producing mixed culture biofilms made up of algae and bacteria. Growth substrata were evaluated for attachment and biofilm formation, and an effective substratum was discovered. The RABR achieved effective nutrient reduction, with average removal rates of 2.1 and 14.1 g m−2 day−1 for total dissolved phosphorus and total dissolved nitrogen, respectively. Biomass production ranged from 5.5 g m−2 day−1 at bench scale to as high as 31 g m−2 day−1 at pilot scale. An efficient spool harvesting technique was also developed at bench and medium scales to obtain a concentrated product (12–16% solids) suitable for further processing in the production of biofuels and bioproducts. Biotechnol. Bioeng. 2012; 109:1674–1684. © 2012 Wiley Periodicals, Inc.
Skin tissue generation by laser cell printing
Authors: Koch Lothar , Deiwick Andrea , Schlie Sabrina , Michael Stefanie , Gruene Martin , Coger Vincent , Zychlinski Daniela , Schambach Axel , Reimers Kerstin , Vogt Peter M. , Chichkov Boris
Published: January 2012

For the aim of ex vivo engineering of functional tissue substitutes, Laser‐assisted BioPrinting (LaBP) is under investigation for the arrangement of living cells in predefined patterns. So far three‐dimensional (3D) arrangements of single or two‐dimensional (2D) patterning of different cell types have been presented. It has been shown that cells are not harmed by the printing procedure. We now demonstrate for the first time the 3D arrangement of vital cells by LaBP as multicellular grafts analogous to native archetype and the formation of tissue by these cells. For this purpose, fibroblasts and keratinocytes embedded in collagen were printed in 3D as a simple example for skin tissue. To study cell functions and tissue formation process in 3D, different characteristics, such as cell localisation and proliferation were investigated. We further analysed the formation of adhering and gap junctions, which are fundamental for tissue morphogenesis and cohesion. In this study, it was demonstrated that LaBP is an outstanding tool for the generation of multicellular 3D constructs mimicking tissue functions. These findings are promising for the realisation of 3D in vitro models and tissue substitutes for many applications in tissue engineering. Biotechnol. Bioeng. 2012; 109:1855–1863. © 2012 Wiley Periodicals, Inc.
Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer
Authors: Segelman J , Granath F , Holm T , Machado M , Mahteme H , Martling A
Published: January 2012

Background

This was a population-based cohort study to determine the incidence, prevalence and risk factors for peritoneal carcinomatosis (PC) from colorectal cancer.

Methods

Prospectively collected data were obtained from the Regional Quality Registry. The Cox proportional hazards regression model was used for multivariable analysis of clinicopathological factors to determine independent predictors of PC.

Results

All 11 124 patients with colorectal cancer in Stockholm County during 1995–2007 were included and followed until 2010. In total, 924 patients (8·3 per cent) had synchronous or metachronous PC. PC was the first and only localization of metastases in 535 patients (4·8 per cent). The prevalence of synchronous PC was 4·3 per cent (477 of 11 124). The cumulative incidence of metachronous PC was 4·2 per cent (447 of 10 646). Independent predictors for metachronous PC were colonic cancer (hazard ratio (HR) 1·77, 95 per cent confidence interval 1·31 to 2·39; P = 0·002 for right-sided colonic cancer), advanced tumour (T) status (HR 9·98, 3·10 to 32·11; P < 0·001 for T4), advanced node (N) status (HR 7·41, 4·78 to 11·51; P < 0·001 for N2 with fewer than 12 lymph nodes examined), emergency surgery (HR 2·11, 1·66 to 2·69; P < 0·001) and non-radical resection of the primary tumour (HR 2·75, 2·10 to 3·61; P < 0·001 for R2 resection). Patients aged > 70 years had a decreased risk of metachronous PC (HR 0·69, 0·55 to 0·87; P = 0·003).

Conclusion

PC is common in patients with colorectal cancer and is associated with identifiable risk factors.
An Enzyme Catalyzing O‐Prenylation of the Glucose Moiety of Fusicoccin A, a Diterpene Glucoside Produced by the Fungus Phomopsis amygdali
Authors: Noike Motoyoshi , Liu Chengwei , Ono Yusuke , Hamano Yoshimitsu , Toyomasu Tomonobu , Sassa Takeshi , Kato Nobuo , Dairi Tohru
Published: January 2012

Isoprenoids form the largest family of compounds found in nature. Isoprenoids are often attached to other moieties such as aromatic compounds, indoles/tryptophan, and flavonoids. These reactions are catalyzed by three phylogenetically distinct prenyltransferases: soluble aromatic prenyltransferases identified mainly in actinobacteria, soluble indole prenyltransferases mostly in fungi, and membrane‐bound prenyltransferases in various organisms. Fusicoccin A (FC A) is a diterpene glycoside produced by the plant‐pathogenic fungus Phomopsis amygdali and has a unique O‐prenylated glucose moiety. In this study, we identified for the first time, from a genome database of P. amygdali, a gene (papt) encoding a prenyltransferase that reversibly transfers dimethylallyl diphosphate (DMAPP) to the 6′‐hydroxy group of the glucose moiety of FC A to yield an O‐prenylated sugar. An in vitro assay with a recombinant enzyme was also developed. Detailed analyses with recombinant PAPT showed that the enzyme is likely to be a monomer and requires no divalent cations. The optimum pH and temperature were 8.0 and 50 °C, respectively. Km values were calculated as 0.49±0.037 μM for FC P (a plausible intermediate of FC A biosynthesis) and 8.3±0.63 μM for DMAPP, with a kcat of 55.3±3.3×10−3 s. The enzyme did not act on representative substrates of the above‐mentioned three types of prenyltransferase, but showed a weak transfer activity of geranyl diphosphate to FC P.
Tuning the Photocatalytic Activity of CdS Nanocrystals through Intermolecular Interactions in Ionic‐Liquid Solvent Systems
Authors: Wing‐hei Lau Vincent , van de Water Leon G. A. , Masters Anthony F. , Maschmeyer Thomas
Published: January 2012

Synthetic solvent systems for the fine‐tuned preparation of CdS nanocrystallites, active in visible‐light photocatalytic hydrogen production, were studied. To control crystallite size and spectral properties, the CdS crystals were synthesised by using different solvent systems, containing a series of tetrabutylammonium amino carboxylate ionic liquids as the crystal‐growth control agents. Six samples of CdS, all with similar physical and spectral properties, exhibited greatly varying photocatalytic activity, with the most active sample outperforming the least active one by almost 60 %. To rationalise this effect, the intermolecular interactions of the synthesis solvent system with the growing CdS nanocrystallites were characterised by using the Reichart betaine dye and the ${E{{{\rm N}\hfill \atop {\rm T}\hfill}}}$ polarity scale. A correlation was observed between the ${E{{{\rm N}\hfill \atop {\rm T}\hfill}}}$ values of the solvent system and the photocatalytic activity of the CdS nanocrystallite, suggesting that the hydrogen‐bond‐donating ability and/or dipolarity/polarisability interactions of the solvent system led to the preferential formation of active surfaces/surface sites on the CdS crystals.
ChemInform Abstract: Bi2(IO4)(IO3)3: A New Potential Infrared Nonlinear Optical Material Containing [IO4]3‐ Anion.
Authors: Cao Zhenbo , Yue Yinchao , Yao Jiyong , Lin Zheshuai , He Ran , Hu Zhanggui
Published: January 2012

The title compound is synthesized by hydrothermal reaction of Bi(NO3)3, HIO3, and HNO3 in H2O (pH ≈0.5, 215 °C, autoclave, 5 d; 75% yield).
ChemInform Abstract: (C4N2H12)(NH4)2 [(GeO2)3(GeO1.5F3)2]: A New Layered Germanate Containing Helical Arrays of H‐Bond.
Authors: Pan Qinhe , Ren Xiaoyan , Xu Yan , Yan Wenfu
Published: January 2012

The new layered title germanate co‐templated by diprotonated piperazine cations and ammonium ions is synthesized by solvothermal reaction of GeO2, piperazine, and NH4F in sBuOH (180 °C, autoclave, 4 d).
ChemInform Abstract: A Spin‐Frustrated Cobalt(II) Carbonate Pyrochlore Network.
Authors: Zheng Yanzhen , Ellern Arkady , Koegerler Paul
Published: January 2012

Co(CO3)2Na3Cl is prepared by solvothermal reaction of CoCl2, Na2CO3, and phen in a 12:1 EtOH/H2O mixture (autoclave, 433 K, 96 h, 42% yield).
ChemInform Abstract: Microwave‐Assisted Solvent‐Dependent Reaction: Chemoselective Synthesis of Quinoxalin‐2(1H)‐ones, Benzo[d]imidazoles and Dipeptides.
Authors: Wang Shu‐Liang , Ding Jie , Jiang Bo , Gao Yuan , Tu Shu‐Jiang
Published: January 2012

Combinatorial syntheses of the title compounds are achieved by microwave‐assisted reaction of 10 arylidenephenyloxazolones [e.g. (I)] with 8 ortho‐diamines [e.g. (II) and (III)] in various solvents.
ChemInform Abstract: The Reaction of Optically Active α‐Aminocarboxylic Acid Hydrazides with Triethyl Orthoesters.
Authors: Kudelko Agnieszka , Zielinski Wojciech , Ejsmont Krzysztof
Published: January 2012

Electronic and steric effects of the substituents at the α‐position of the hydrazides influences the chemoselectivity of the ring closure affording triazinones and/or 2‐aminomethyl‐1,3,4‐oxadiazoles.
ChemInform Abstract: Environmentally Benign Metal Triflate‐Catalyzed Reductive Cleavage of the C—O Bond of Acetals to Ethers.
Authors: Zhang Yin‐Jie , Dayoub Wissam , Chen Guo‐Rong , Lemaire Marc
Published: January 2012

A mild and efficient protocol for the cleavage of the C‐O bonds of aromatic and aliphatic acetals to ethers without affecting aromatic rings, nitro, nitrile, ester, and hydroxyl groups is reported.
ChemInform Abstract: Mild and Tunable Benzoic Acid Catalysts for Rearrangement Reactions of Allylic Alcohols.
Authors: McCubbin J. Adam , Voth Samantha , Krokhin Oleg V.
Published: January 2012

Benzoic acids (I) efficiently promote the rearrangement to regioisomeric (E)‐allylic alcohols including synthetically useful dienol and enynol derivatives.
ChemInform Abstract: An Ester Enolate—Claisen Rearrangement Route to Substituted 4‐Alkylideneprolines. Studies Toward a Definitive Structural Revision of Lucentamycin A.
Authors: Ranatunga Sujeewa , Kim Jinsoo S. , Pal Ujjwal , Del Valle Juan R.
Published: January 2012

In the presence of NaN(Tms)2, esters of type (I) and (IX) rearrange to amino acids like (II) and (X) with moderate to high diastereoselectivity.
ChemInform Abstract: Copper‐Catalyzed, Aerobic Oxidative Cross‐Coupling of Alkynes with Arylboronic Acids: Remarkable Selectivity in 2,6‐Lutidine Media.
Authors: Yasukawa Tomohiro , Miyamura Hiroyuki , Kobayashi Shu
Published: January 2012

By fine‐tuning the reaction conditions, the coupling products are obtained in high yields and selectivities.
ChemInform Abstract: Chemoselective Transfer of Allyl or Phenyl Group from Allyl(phenyl)germanes in Pd‐Catalyzed Reactions with Aryl Halides.
Authors: Pitteloud Jean‐Philippe , Liang Yong , Wnuk Stanislaw F.
Published: January 2012

The chemoselective Stille‐like synthesis of the compounds (III) also gives the homocoupling by‐products.
ChemInform Abstract: A Mild Ligand‐Free Iron‐Catalyzed Liberation of Alcohols from Allylcarbonates.
Authors: Dieskau Andre P. , Plietker Bernd
Published: January 2012

Both iron catalysts produce generally similar yields.
ChemInform Abstract: Synthesis and Biological Activity of Desmethoxy Analogues of Coruscanone A.
Authors: Tichotova Lucie , Matousova Eliska , Spulak Marcel , Kunes Jiri , Votruba Ivan , Buchta Vladimir , Pour Milan
Published: January 2012

A wide range of simple desmethoxy analogues of coruscanone A is synthesized via a novel version of the Ti(O‐iPr)4‐‐mediated Knoevenagel condensation of cyclopentenedione with substituted benzaldehydes and cinnamic aldehydes.
ChemInform Abstract: ortho‐Bromo(propa‐1,2‐dien‐1‐yl)arenes: Substrates for Domino Reactions.
Authors: Masters Kye‐Simeon , Wallesch Manuela , Braese Stefan
Published: January 2012

Pd‐catalyzed treatment of the title compounds, with benzamides or acetamides results in new, unprecedented formation of indole derivatives like (VII), (XIII) and (XIV).
ChemInform Abstract: Gold‐ and Iodine‐Mediated Internal Oxygen Transfer of Nitrone‐ and Sulfoxide‐Functionalized Alkynes.
Authors: Chen Dan , Song Guoyong , Jia Aiqun , Li Xingwei
Published: January 2012

Treatment of nitrones of type (I) and (IV) with iodine results in selective formation of isoindolones.
ChemInform Abstract: Facile Synthesis of β,β‐Difluorostyrenes via the Negishi Coupling of Thermally Stable 2,2‐Difluorovinyl Zinc—TMEDA Complex.
Authors: Fujita Takeshi , Ichisuka Tomohiro , Fuchibe Kohei , Ichikawa Junji
Published: January 2012

The presented reaction proceeds smoothly with sterically hindered triflates and halides with an excellent chemoselectivity for multihalogenated substrates (order of reactivity I < OTf < Br < Cl).
ChemInform Abstract: The Long‐Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo‐ and Enantioselectivity of the Tandem 1,4‐Addition/Fluorination.
Authors: Wang Lian , Meng Wei , Zhu Chuan‐Le , Zheng Yan , Nie Jing , Ma Jun‐An
Published: January 2012

The sequence, applied to acrylic β‐ketoesters, offers a novel synthesis of chiral α‐fluoro‐β‐ketoesters.
ChemInform Abstract: Pd(II)‐Catalyzed para‐Selective C—H Arylation of Monosubstituted Arenes.
Authors: Wang Xisheng , Leow Dasheng , Yu Jin‐Quan
Published: January 2012

Reaction of various unsubstituted or monosubstituted arenes with benzamides applies N‐fluorobenzenesulfonimide as a bystanding oxidant to provide the corresponding biaryls with high para‐selectivity.
ChemInform Abstract: Kumada—Tamao—Corriu Coupling Using N‐Heterocyclic Carbene Ligands Bearing Pyridyl and Ethylenedioxyl Moieties.
Authors: Mitsudo Koichi , Doi Yuta , Sakamoto Syunsuke , Murakami Hiroki , Mandai Hiroki , Suga Seiji
Published: January 2012

Imidazole based carbene ligands bearing pyridyl and ethylenedioxyl moieties at the nitrogen atoms are developed and utilized as ligands in the nickel‐catalyzed title coupling.
ChemInform Abstract: CsF Mediated Rapid Condensation of 1,3‐Cyclohexadione with Aromatic Aldehydes: Comparative Study of Conventional Heating vs. Ambient Temperature.
Authors: Nandre Kamalakar P. , Patil Vijay S. , Bhosale Sidhanath V.
Published: January 2012

The condensation of substrate (I) with aromatic aldehydes gives dicyclohexane‐1,3‐diones (III) or xanthene derivatives (IV) depending on the reaction temperature.
ChemInform Abstract: Guanidine Hydrochloride: An Active and Simple Catalyst for Mannich‐Type Reaction in Solvent‐Free Condition.
Authors: Heravi Majid M. , Zakeri Masoumeh , Mohammadi Narges
Published: January 2012

A novel methodology offers advantages such as solvent‐free conditions, no need for any base, metal or Lewis acid catalyst as well as ease of product isolation.
ChemInform Abstract: A New Chemical Access for 3′‐Acetyl‐4′‐hydroxychalcones Using Borontrifluoride‐etherate via a Regioselective Claisen—Schmidt Condensation and Its Application in the Synthesis of Chalcone Hybrids.
Authors: Narender T. , Venkateswarlu K. , Nayak B. Vishnu , Sarkar S.
Published: January 2012

The Claisen—Schmidt condensation of the unsymmetrical bisacetylarene (I) with various aldehydes under optimized conditions affords chalcones (III) in good yields.
ChemInform Abstract: Copper‐Catalyzed Sila‐Sonogashira—Hagihara Cross‐Coupling Reactions of Alkynylsilanes with Aryl Iodides under Palladium‐Free Conditions.
Authors: Nishihara Yasushi , Noyori Shintaro , Okamoto Takeru , Suetsugu Masato , Iwasaki Masayuki
Published: January 2012

An efficient and inexpensive catalytic system for the synthesis of the unsymmetrical diarylethynes (III), (V) and (VII) is developed.
ChemInform Abstract: Kumada—Tamao—Corriu Coupling of Alkyl Halides Catalyzed by an Iron—Bisphosphine Complex.
Authors: Hatakeyama Takuji , Fujiwara Yu‐ichi , Okada Yoshihiro , Itoh Takuma , Hashimoto Toru , Kawamura Shintaro , Ogata Kazuki , Takaya Hikaru , Nakamura Masaharu
Published: January 2012

A highly efficient method for the title reaction is presented.
ChemInform Abstract: Combination of Rearrangement with Metallic and Organic Catalyses — A Step‐ and Atom‐Economical Approach to α‐Spirolactones and ‐lactams.
Authors: Boddaert Thomas , Coquerel Yoann , Rodriguez Jean
Published: January 2012

A general one‐pot synthesis of α‐spirolactones and ‐lactams is presented, involving a Wolff rearrangement—α‐oxoketene trapping—cross metathesis—Michael addition sequence.
ChemInform Abstract: Mild, Convenient and Efficient Synthesis of Novel 2,2‐Dichloro‐1,3‐diarylaziridines from Schiff Bases by Phase Transfer CTAB Catalysis under Low Concentration Alkaline Conditions.
Authors: Naeimi Hossein , Rabiei Khadijeh
Published: January 2012

The use of a phase transfer catalyst dramatically enhances the reaction of Schiff bases with chloroform to produce aziridines (III) in short reaction times.
ChemInform Abstract: A Highly Enantioselective One‐Pot Synthesis of Spirolactones by an Organocatalyzed Michael Addition/Cyclization Sequence.
Authors: Sternativo Silvia , Calandriello Antonella , Costantino Ferdinando , Testaferri Lorenzo , Tiecco Marcello , Marini Francesca
Published: January 2012

The reaction of a variety of tert‐butyl β‐ketoesters with vinyl selenone in the presence of CIE generates a Michael intermediate which is cyclized by treatment with silica gel to give spirolactams with high levels of enantioselectivity.
ChemInform Abstract: Asymmetric Construction of Trifluoromethylated Pyrrolidines via Cu(I)‐Catalyzed 1,3‐Dipolar Cycloaddition of Azomethine Ylides with 4,4,4‐Trifluorocrotonates.
Authors: Li Qing‐Hua , Tong Min‐Chao , Li Jun , Tao Hai‐Yan , Wang Chun‐Jiang
Published: January 2012

The first enantioselective synthesis of trifluoromethylated pyrrolidines (III) and (V) via Cu(I)‐catalyzed 1,3‐dipolar cycloaddition of azomethine ylides with trans‐ and cis‐trifluoromethylcrotonates (II) and (IV) is reported.
ChemInform Abstract: A Facile Approach to trans‐4,5‐Pyrrolidine Lactam and Application in the Synthesis of Nemonapride and Streptopyrrolidine.
Authors: Huang Wei , Ma Jing‐Yi , Yuan Mu , Xu Long‐Fei , Wei Bang‐Guo
Published: January 2012

A ′one‐pot′ oxidative cyclization using NaIO4 and a ruthenium catalyst is applied to the highly diastereoselectively formed terminal alkenes (II) after Tbs‐protection.
ChemInform Abstract: Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters.
Authors: Cao Yiming , Jiang Xianxing , Liu Luping , Shen Fangfang , Zhang Futing , Wang Rui
Published: January 2012

The process uses a thiourea as chiral organocatalyst and allows the construction of densely functionalized 3,3′‐pyrrolidinoyl spirooxindoles with three contiguous stereogenic centers.
ChemInform Abstract: A Bioinspired Ugi/Michael/Aza‐Michael Cascade Reaction in Aqueous Media: Natural‐Product‐Like Molecular Diversity.
Authors: Santra Soumava , Andreana Peter R.
Published: January 2012

The two‐stage microwave irradiation yields polycyclic N‐heterocycles as skeletons of natural substances.
ChemInform Abstract: A Simple Synthesis of 5‐(2‐Aminophenyl)‐1H‐pyrazoles.
Authors: Svete Jurij , et al. et al.
Published: January 2012

Title compounds which are analogues of histamine are synthesized in three steps.
ChemInform Abstract: Synthesis of Benzimidazole‐Fused Heterocycles by Intramolecular Oxidative C—N Bond Formation Using Hypervalent Iodine Reagents.
Authors: Kutsumura Noriki , Kunimatsu Shinichi , Kagawa Kimiko , Otani Takashi , Saito Takao
Published: January 2012

The preparation of title heterocycles is investigated by oxidation of appropriate substrates with hypervalent iodine reagents.
ChemInform Abstract: Highly Efficient Dialkylphosphate‐Mediated Syntheses of Hydantoins and a Bicyclohydantoin under Solvent‐Free Conditions.
Authors: Kumar Vinod , Rana Hemlata , Sankolli Ravish , Kaushik M. P.
Published: January 2012

A novel synthesis of hydantoins with a variety of substituents is achieved by thermal cyclocondensation.
ChemInform Abstract: DPO and POPOP Carboxylate‐Analogue Sensors by Sequential Palladium‐Catalyzed Direct Arylation of Oxazole‐4‐carboxylates.
Authors: Verrier Cecile , Fiol‐Petit Catherine , Hoarau Christophe , Marsais Francis
Published: January 2012

Several 2,5‐diaryloxazole derivatives of type (III) (14 examples) and bisoxazoles of type (VI) (7 examples) are prepared by the title method.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative C‐Arylation of a Benzo[d]oxazole C—H Bond with Arene Sulfonyl Chlorides.
Authors: Zhang Manli , Zhang Shouhui , Liu Miaochang , Cheng Jiang
Published: January 2012

The convenient, novel protocol tolerates the presence of a variety of functional groups.
ChemInform Abstract: Synthesis and Antimicrobial Studies of Pyrazolyl Oxadiazoles and Thiadiazoles.
Authors: Padmavathi Venkatapuram , Reddy Sanapalli Nagi , Reddy Guda Dinneswara , Venkatesh Bhumireddy C. , Padmaja Adivireddy
Published: January 2012

Compounds (VIIa) and (VIIc) exhibit excellent antibacterial activity against Gram‐positive bacteria and good activity against Gram‐negative bacteria.
ChemInform Abstract: Palladium‐Catalyzed Coupling of 3‐Halo‐Substituted Coumarins, Chromenes, and Quinolones with Various Nitrogen‐Containing Nucleophiles.
Authors: Soussi Mohamed Ali , Audisio Davide , Messaoudi Samir , Provot Olivier , Brion Jean‐Daniel , Alami Mouad
Published: January 2012

A variety of 3‐halocoumarin, ‐quinolinone and ‐chromene derivatives smoothly undergoes coupling with a diversity of N‐nucleophiles like amides, sulfonamides, lactams, azoles, amines and amino acids.
ChemInform Abstract: Synthesis of 4H‐Chromene Derivatives by Reaction Between Alkyl Isocyanides and Dialkyl Acetylenedicarboxylate in the Presence of 6‐Hydroxyquinoline.
Authors: Mohtat Bita , Djahaniani Hoorieh , Yavari Issa , Dehbalaei Masomeh G. , Jam Saba A.
Published: January 2012

The addition of isocyanides to esters (III) generates a reactive intermediate which is trapped by 6‐quinolinol.
ChemInform Abstract: Stereoselective Synthesis of cis‐3,4‐Disubstituted Piperidines Through Ring Transformation of 2‐(2‐Mesyloxyethyl)azetidines.
Authors: Mollet Karen , Catak Saron , Waroquier Michel , Van Speybroeck Veronique , D'hooghe Matthias , De Kimpe Norbert
Published: January 2012

Treatment of the azetidines (I) with nucleophiles allows a new and convenient access to the target compounds.
ChemInform Abstract: Palladium‐Catalyzed Direct ortho C—H Arylation of 2‐Arylpyridine Derivatives with Aryltrimethoxysilane.
Authors: Li Wu , Yin Zhangwei , Jiang Xiaoqing , Sun Peipei
Published: January 2012

It allows a new, convenient, and environmentally friendly access to various triaryls of type (III) and (V).
ChemInform Abstract: Discovery of Spiropiperidine‐Based Potent and Selective Orexin‐2 Receptor Antagonists.
Authors: Fujimoto Tatsuhiko , Tomata Yoshihide , Kunitomo Jun , Hirozane Mariko , Marui Shogo
Published: January 2012

A spiropiperidine‐based scaffold is designed and a SAR study is carried out.
ChemInform Abstract: A New Four‐Component Reaction for the Synthesis of Spiro[4H‐indeno[1,2‐b]pyridine‐4,3′‐[3H]indoles].
Authors: Feiz Afsaneh , Shakibaei Ghazaleh Imani , Yasaei Zahra , Khavasi Hamid Reza , Bazgir Ayoob
Published: January 2012

Synthesis of target compounds (IV) and (VI) is achieved using commercially available compounds.
ChemInform Abstract: Synthesis of Novel Thiazolyl‐Pyrimidines and Their Anticancer Activity in vitro.
Authors: Shi Hai‐Bo , Li Hai‐Bo , Lu Kong‐Qin , Zhu Xia‐Re , Hu Wei‐Xiao , Pei Wen
Published: January 2012

Some of the novel title compounds (III) (37 examples) show moderate or high cytotoxic activity against human cancer cell lines.
ChemInform Abstract: An Oxidative Alkylamination of 1,3,7‐Triazapyrenes in the Aqueous Medium.
Authors: Borovlev Ivan , Demidov Oleg , Saigakova Nadezhda , Pisarenko Sergey , Nemykina Olesya
Published: January 2012

The applied reaction conditions can be regarded as green chemistry.
ChemInform Abstract: 1,4‐Diaryl‐7,10‐dimethoxyquinoxalino[2,3‐b]quinoxalines and Their Dihydro Derivatives: Redox Switching of NIR Absorption and Fluorescence.
Authors: Miura Youhei , Kawai Hidetoshi , Fujiwara Kenshu , Suzuki Takanori
Published: January 2012

The optical properties of the deeply colored dyes (VIII), which exhibit absorption bands extended to the NIR region, and (VII), which emit strong green fluorescence, are investigated in CH2Cl2.
ChemInform Abstract: Divergent Regioselective Synthesis of 2,5,6,7‐Tetrahydro‐1H‐1,4‐diazepin‐2‐ones and 5H‐1,4‐Benzodiazepines.
Authors: Attanasi Orazio A. , De Crescentini Lucia , Favi Gianfranco , Mantellini Fabio , Nicolini Simona
Published: January 2012

Coupling of 1,2‐diaza‐1,3‐dienes with N‐unsubstituted 1,3‐diamines allows a new and easy access to the diazepinone skeleton.
ChemInform Abstract: Mizoroki—Heck Reaction of (1‐Fluorovinyl)methyldiphenylsilane with Aryl Iodides.
Authors: Hirotaki Kensuke , Hanamoto Takeshi
Published: January 2012

The title reaction allows an efficient and highly selective access to (E)‐vinylsilanes of type (III).
ChemInform Abstract: Synthesis of Acylsilanes by Palladium‐Catalyzed Cross‐Coupling Reaction of Thiol Esters and Silylzinc Chlorides.
Authors: Azuma Hiroki , Okano Kentaro , Tokuyama Hidetoshi
Published: January 2012

Thiol esters (I), possessing a variety of functional groups, are converted to acylsilanes (III) in moderate to high yields by the title reaction using silylating reagent (II).
ChemInform Abstract: Catalytic and Direct Oxyphosphorylation of Alkenes with Dioxygen and H‐Phosphonates Leading to β‐Ketophosphonates.
Authors: Wei Wei , Ji Jian‐Xin
Published: January 2012

The reaction can be successfully carried out with styrenes, enamine (IIf) and dihydronaphthalene (VII).
ChemInform Abstract: Synthesis, Photophysical Properties of Tribranched Chromophores Based on 1,3,5‐Triazine Core and Different Electro‐Donating Eng‐Groups.
Authors: Liu Li , Huang Wei , Shi Jieping , Lue Changgui , Cui Yiping , Lu Guo‐Yuan
Published: January 2012

All four chromophores show strong fluorescence emission and are soluble in common organic solvents.
ChemInform Abstract: Antihepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus.
Authors: Pu Jian‐xin , Sun Han‐dong , et al. et al.
Published: January 2012

4 New diterpenoids named isolophanthins A—D (I) and (II) are isolated from Isodon lophantoides var.
ChemInform Abstract: New Green Synthesis and Formulations of Acyclovir Prodrugs.
Authors: de Regil‐Hernandez Ruben , Martinez‐Lagos Fernando , Rodriguez‐Bayon Amalia , Sinisterra Jose‐Vicente
Published: January 2012

Different methods are described for the synthesis of acyclovir prodrugs of type (III).
ChemInform Abstract: Flavusides A and B, Antibacterial Cerebrosides from the Marine‐Derived Fungus Aspergillus flavus.
Authors: Yang Guohua , Sandjo Louis , Yun Keumja , Leutou Alain Simplice , Kim Gun‐Do , Choi Hong Dae , Kang Jung Sook , Hong Jongki , Son Byeng Wha
Published: January 2012

Extraction, isolation, and structure elucidation of title compounds (I) are described.
ChemInform Abstract: Coprismycins A and B, Neuroprotective Phenylpyridines from the Dung Beetle‐Associated Bacterium, Streptomyces sp.
Authors: Kim Seong‐Hwan , Ko Hyeonseok , Bang Hea‐Son , Park Seon‐Hui , Kim Dong‐Gyu , Kwon Hak Cheol , Kim Sun Yeou , Shin Jongheon , Oh Dong‐Chan
Published: January 2012

The new isomeric phenylpyridines (I) and (II), named coprismycins A and B, resp., are isolated along with four known dipyridines from a culture of Streptomyces sp., associated with an indigenous Korean dung beetle.
ChemInform Abstract: Coordination‐Driven Supramolecular Assembly of Phosphole‐Based π‐Conjugated Ligands
Authors: Crassous J. , Lescop C. , Reau R.
Published: January 2012

Review: 128 refs.
ChemInform Abstract: Microwave Assisted Synthesis of Fused Heterocyclic Compounds
Authors: Srinivasan Kumar V. , Chaskar Pratip K. , Dighe Satish N. , Rane Dhanashri S. , Khade Pranav V. , Jain Kishor S.
Published: January 2012

Review: benzimidazoles, fused thiadiazoles, pyrimidoimidazoles, triazolotetrazines etc.; 85 refs.
ChemInform Abstract: Recent Advances in the Total Synthesis of Indolizidine Iminosugars
Authors: Kim In Su , Jung Young Hoon
Published: January 2012

Review: 45 refs.
ChemInform Abstract: Recent Progress in Synthesis and Bioactivity Studies of Indolizines
Authors: Singh Girija S. , Mmatli Edward E.
Published: January 2012

Review: 116 refs.
ChemInform Abstract: Coordination Polymers and Metal Organic Frameworks Derived from 1,2,4‐Triazole Amino Acid Linkers
Authors: Naik Anil D. , Dirtu Marinela M. , Railliet Antoine P. , Marchand‐Brynaert Jacqueline , Garcia Yann
Published: January 2012

Review: 120 refs.
ChemInform Abstract: Chemical Synthesis of Furanose Glycosides
Authors: Imamura Akihiro , Lowary Todd
Published: January 2012

Review: 106 refs.
ChemInform Abstract: Recent Strategies for Stereoselective Sialylation and Their Application to the Synthesis of Oligosialosides
Authors: Hanashima Shinya
Published: January 2012

Review: 58 refs.
ChemInform Abstract: Formation and Function of Nano‐ and Microstructures by the Self‐Assembly of Cyclic Oligosaccharides ′Cyclodextrins′
Authors: Kida Toshiyuki
Published: January 2012

Review: 40 refs.
ChemInform Abstract: Development of Biomimetic Catalytic Oxidation Methods and Non‐Salt Methods Using Transition Metal Based Acid and Base Ambiphilic Catalysts
Authors: Murahashi Shun‐ichi
Published: January 2012

Review: 60 refs.
ChemInform Abstract: Hydrocarbon σ‐Radical Cations
Authors: Shubina Tatyana E. , Fokin Andrey A.
Published: January 2012

Review: 149 refs.
ChemInform Abstract: Chiral Spiro Catalysts
Authors: Zhou Qi‐Lin , Xie Jian‐Hua
Published: January 2012

Review: 119 refs.
ChemInform Abstract: A Formidable Challenge: Catalytic Asymmetric Dichlorination.
Authors: Monaco Mattia R. , Bella Marco
Published: January 2012

Review: 20 refs.
ChemInform Abstract: Selective Crossed‐Tishchenko Reaction — A Waste‐Free Synthesis of Benzyl Esters.
Authors: Dzik Wojciech I. , Goossen Lukas J.
Published: January 2012

Review: 21 refs.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative C—H Functionalizations: Trends and Mechanistic Insights.
Authors: Wendlandt Alison E. , Suess Alison M. , Stahl Shannon S.
Published: January 2012

Review: about 200 refs.
ChemInform Abstract: 2011: 50th Anniversary of the Discovery of the Genetic Code
Authors: Erdmann Volker A. , Barciszewski Jan
Published: January 2012

Review: 46 refs.
ChemInform Abstract: Elucidating the Function of Complex‐Type Oligosaccharides by Use of Chemical Synthesis of Homogeneous Glycoproteins
Authors: Kajihara Yasuhiro , Izumi Masayuki , Hirano Kiriko , Murase Takefumi , MacMillan Derek , Okamoto Ryo
Published: January 2012

Review: 56 refs.
ChemInform Abstract: Bioavailability Enhancement of Poorly Water Soluble Drugs: A Review
Authors: Gupta Atul Kumar , Sehrawat Susheel Kumar
Published: January 2012

Review: 76 refs.
ChemInform Abstract: On the Frontier: Analytical Chemistry and the Occurrence of Illicit Drugs in Surface Waters in the United States
Authors: Jones‐Lepp Tammy , Alvarez David , Loganathan Bommanna
Published: January 2012

Review: 54 refs.
8‐Substituted 3‐Arylcoumarins as Potent and Selective MAO‐B Inhibitors: Synthesis, Pharmacological Evaluation, and Docking Studies
Authors: Viña Dolores , Matos Maria J. , Ferino Giulio , Cadoni Enzo , Laguna Reyes , Borges Fernanda , Uriarte Eugenio , Santana Lourdes
Published: January 2012

Neurodegenerative disorders are becoming more prevalent given the increase in the aging population. This has inspired active research in the development of new drugs that could mark an important advance in the treatment of complex diseases such as Alzheimer′s and Parkinson′s. With the aim of finding new MAO‐B‐selective inhibitors, we report the synthesis, in vitro evaluation, and docking simulation of a new series of 3‐arylcoumarins variously substituted at the 8‐position. Most of the studied compounds show high affinity and selectivity for the hMAO‐B isoform, with IC50 values in the low micro‐ to nanomolar range. Some of them have greater hMAO‐B inhibitory activity and selectivity than the reference compound, selegiline. Compounds 7 and 8 are the most active of this series, with compound 8 being fivefold more potent against MAO‐B and severalfold more selective than selegiline. Docking experiments were carried out with hMAO‐B crystal structures, providing new information about the enzyme–inhibitor interaction and the potential therapeutic application of the new 8‐substituted 3‐arylcoumarins.
Individual differences in human colour vision as derived from stiles & Burch 10° colour matching functions
Authors: Logvinenko Alexander D.
Published: January 2012

Individual differences between the 49 Stiles & Burch observers have been analyzed using the object‐colour space put forth recently (J of Vision 2009;9:1–23). A set of rectangular reflectance spectra has been used as a common frame of reference for representing object colours for all the observers. Being metameric to one of these rectangular reflectance spectra, every reflectance spectrum can be geometrically represented as a point in the three‐dimentional space. The interindividual differences reveal themselves in that, for various observers, the same reflectance spectrum maps to different points in this space. It has been found that on average such differences do not exceed the differences in object‐colour appearance induced by an illumination shift from daylight to the fluorescent daylight simulator F1. Such small individual variations have been accounted for by the fact that the cone spectral tuning curves have a special form that mitigates the individual differences in cone spectral positioning. © 2012 Wiley Periodicals, Inc. Col Res Appl, 2013
Analyses of color emotion for color pairs with independent component analysis and factor analysis
Authors: Hanada Mitsuhiko
Published: January 2012

Semantic‐differential data of color emotions for color pairs were collected and examined with factor analysis (FA) and independent component analysis (ICA). The axial orientations of factors cannot be identified by FA, whereas they can be determined by ICA with the intrinsic statistical properties of data such as kurtosis. Three factors or components were extracted by FA and ICA. The factors extracted by FA with the varimax method were consistent with the primary factors: evaluation, activity, and potency. When ICA extracted components with positive kurtosis, the components did not match any of the primary factors. However, the independent components extracted by ICA for negative kurtosis were consistent with the primary factors, and similar to the factors obtained by FA. The results of ICA suggest that the evaluation, activity, and potency factors are independent dimensions in psychological space of color emotions for color pairs. The distributions of the factor scores in FA and the scores of the independent components obtained by ICA for negative kurtosis were not Gaussian, but they had negative kurtosis. These support the use ofICA instead of FA. © 2012 Wiley Periodicals, Inc. Col Res Appl, 38, 297–308, 2013
Isomerisation of CF2ClCH2Cl and CFCl2CH2F by Interchange of Cl and F Atoms with Analysis of the Unimolecular Reactions of Both Molecules
Authors: Solaka Sarah A. , Boshamer Sara E. , Parworth Caroline L. , Heard George L. , Setser D. W. , Holmes Bert E.
Published: January 2012

The recombination of CF2Cl with CH2Cl and CFCl2 with CH2F were employed to generate CF2ClCH2Cl* and CFCl2CH2F* molecules with 381 and 368 kJ mol−1, respectively, of vibrational energy in a room‐temperature bath gas. The unimolecular reactions of these molecules, which include HCl elimination, HF elimination, and isomerisation by interchange of chlorine and fluorine atoms, were characterized. The three rate constants for CFCl2CH2F were 2.9×107, 0.87×107 and 0.04×107 s−1 for HCl elimination, isomerisation and HF elimination, respectively. The isomerisation reaction must be included to have a complete characterization of the unimolecular kinetics of CFCl2CH2F. The rate constants for HCl elimination and HF elimination from CF2ClCH2Cl were 14×107and 0.37×107 s−1, respectively. Isomerisation that has a rate constant less than 0.08×107 s−1 is not important. These experimental rate constants were matched to calculated statistical rate constants to assign threshold energies, which are 264, 268, and 297 kJ mol−1, respectively, for isomerisation, HCl elimination, and HF elimination for CFCl2CH2F and 314, 251, and 289 kJ mol−1 in the same order for CF2ClCH2Cl. Density functional theory was used to evaluate the models that were needed for the statistical rate constants; the computational method was B3PW91/6‐31G(d′,p′). Threshold energies for the unimolecular reactions of CF2ClCH2Cl and CFCl2CH2F are compared to those for CF2ClCH3 and CFCl2CH3 to illustrate the elevation of threshold energies by F‐ or Cl‐atom substitution at the beta carbon atom (identified by CH). The DFT calculations systematically underestimate the threshold energy for HCl elimination.
X‐Ray Photoelectron Spectroscopy of Ferrocenyl‐ and Ferrocenium‐Based Ionic Liquids
Authors: Taylor Alasdair W. , Licence Peter
Published: January 2012

X‐ray photoelectron spectroscopy (XPS) is used to study a series of five 1‐(ferrocenylmethyl)‐3‐methylimidazolium‐ and 1‐(ferroceniummethyl)‐3‐methylimidazolium‐based salts. All samples emit good photoelectron fluxes with sharp, well‐resolved photoelectron peaks. Due to the low volatility of imidazolium‐salts at ambient temperature, no modification of the XP spectrometer was required. Two of the salts exhibit supercooling behaviour, allowing XPS to be recorded at room temperature on liquid samples without the need for charge neutralisation. The photoelectron peaks can be assigned to the component atoms of the salts, based on previous studies on ferrocene, ferrocenium‐compounds and ionic liquids. Oxidation of the ferrocenyl moiety to ferrocenium shiftsthe Fe 2p and cyclopentadienyl C 1s photoelectron peaks to higher binding energy but does not affect the imidazolium and anion peaks. Under charge‐neutralisation conditions, in which the sample is flooded with low‐energy electrons, the ferrocenium moiety of the salt 1‐(ferroceniummethyl)‐3‐methylimidazolium di(hexafluorophosphate) is partially reduced.
Determination of LFER Descriptors of 30 Cations of Ionic Liquids—Progress in Understanding Their Molecular Interaction Potentials
Authors: Cho Chul‐Woong , Jungnickel Christian , Stolte Stefan , Preiss Ulrich , Arning Jürgen , Ranke Johannes , Krossing Ingo , Thöming Jorg
Published: January 2012

In order to understand molecular interaction potentials of 30 cations of ionic liquids (ILs), the well‐known linear free energy relationship concept (LFER) was applied. The LFER descriptors for the excess molar refractivity and the molar volume were calculated in silico and for hydrogen‐bonding acidity and basicity, and the polarizability/dipolarity of IL cations were experimentally determined through high performance liquid chromatography (HPLC) measurements. For the study, three different columns (RP‐select B, Cyan, and Diol) and buffered mobile phases, based on two organic solvents acetonitrile (ACN) and methanol (MeOH), were selectively combined to the HPLC separation systems RP‐select B‐ACN, RP‐select B‐MeOH, Cyan‐MeOH, Diol‐ACN, and Diol‐MeOH. By measuring the retention factors of 45 neutral calibration compounds and calculating LFER descriptors of three cations in the HPLC systems, the system parameters, including an ionic z coefficient, were determined. Conversely, the LFER descriptors of 30 ionic liquid cations were determined, based on the parameters of five systems and their retention factors in the HPLC systems. The results showed that the type of head group, alkyl chain length and further substituents of the cation have a significant influence on the dipolarity/polarizability and the hydrogen‐bonding acidity, and functionalized groups (hydroxyl, ether, and dimethylamino) lead to hydrogen‐bonding basicity of the cation. The characterization of cationic LFER descriptors opens up the chance for a more quantitative understanding of molecular interaction potentials and physicochemical properties of ILs.
Supramolecular Systems Based on Novel Mono‐ and Dicationic Pyrimidinic Amphiphiles and Oligonucleotides: A Self‐Organization and Complexation Study
Authors: Zakharova Lucia , Voronin Mikhail , Semenov Vyacheslav , Gabdrakhmanov Dinar , Syakaev Victor , Gogolev Yuri , Giniyatullin Rashit , Lukashenko Svetlana , Reznik Vladimir , Latypov Shamil , Konovalov Alexander , Zuev Yuri
Published: January 2012

Novel mono‐ and dicationic pyrimidinic surfactants are synthesized and their aggregation behavior is studied by methods of tensiometry and nuclear magnetic resonance (NMR) self‐diffusion. To estimate their potentiality as gene delivery agents, the complexation with oligonucleotides (ONus) is explored by dynamic light scattering (DLS) and zeta‐potential titration methods and ethidium bromide exclusion experiments. Bola‐type pyrimidinic amphiphile (BPM) demonstrates rather a weak affinity to ONus. Although it induces mixed associations with ONus, only slight charge compensation changes occur at a large excess of bola, with no recharging reached. Similarly, the ethydium bromide exclusion study reveals a slow increase in the binding capacity toward an ONu with an increment in BPM concentration. The monocationic pyrimidinic surfactant (MPM) and its gemini analogue (GPM‐1) are ranked as intermediates in both their aggregative activity and complexing properties toward ONus. They both form mixed associates with ONus well below the critical micelle concentrations (cmcs) of 2 and 15 mM respectively. However, GPM‐1 has a much lower isoelectric point at the molar ratio surfactant/ONu r∼1 compared to r∼3 for MPM. This probably indicates a larger electrostatic contribution to the ONu complexation in the case of GPM‐1. The most hydrophobic pyrimidinic surfactant (GPM‐2), bearing three alkyl tails, demonstrates enhanced aggregative activity and binding capacity toward ONus as compared to former pyrimidinic surfactants. Due to effective aggregative (low cmc of 0.04 mM) plus binding properties (fraction of bound ONu β=0.76 at r=2.5), GPM‐2 may be ranked as a promising agent for wider biological applications.
Removing Polyvinylpyrrolidone from Catalytic Pt Nanoparticles without Modification of Superficial Order
Authors: Monzó J. , Koper M. T. M. , Rodriguez P.
Published: January 2012

Herein, we report a simple methodology for cleaning Pt nanoparticles, prepared by a colloidal synthesis and coated with polyvinylpyrrolidone, without loss of crystalline surface structure. To prove the removal of the polyvinylpirrolidone from a Pt surface without disturbing the superficial order, a cleaning method using a solution of H2O2/H2SO4 was tested successfully for a Pt(111) single‐crystal electrode. The decontamination method was then tested for two different types of nanoparticles by mixing the suspension of nanoparticles with H2O2/H2SO4 and subsequent centrifugation. The resulting voltammetric profiles of platinum particles synthesized by the colloidal method employing PVP show a marked presence of the adsorption‐state characteristic of (111) ordered surface domains. The presence of the well‐ordered domains present on the surface of the nanoparticles was confirmed by using the irreversible adsorption of bismuth, tellurium and germanium.