bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Investigation of Conserved miRNAs and Their Targets From the Expressed Sequence Tags in Neospora Caninum Genome
Authors: Das Moumita , Hasan Mahmudul , Akter Sharmin , Roy Sawrab , Sharma Binayok , Chowdhury Md. Shahidur Rahman , Ahsan Md. Irtija , Akhand Rubaiat Nazneen , Uddin Md Bashir , Ahmed Syed Sayeem Uddin
Published: December 2021

Neospora caninum is a protozoan parasite, the etiologic agent of Neosporosis—a common cause of abortion in cattle worldwide. Herd level prevalence of Neosporosis could be as high as 90%. However, there is no approved treatment and vaccines available for Neosporosis. MicroRNA (miRNA) based prophylaxis and therapeutics could be options for Neosporosis in cattle and other animals. The current study aimed to investigate the genome of Neospora caninum to identify and characterize the conserved miRNAs through Expressed Sequence Tags (ESTs) dependent homology search. A total of 1,041 mature miRNAs of reference organisms were employed against 336 non-redundant ESTs available in the genome of Neospora caninum. The study predicted one putative miRNA “nca-miR-9388-5p” of 19 nucleotides with MFEI value -1.51 kcal/mol and (A + U) content% 72.94% corresponding with its pre-miRNA. A comprehensive search for specific gene targets was performed and discovered 16 potential genes associated with different protozoal physiological functions. Significantly, the gene “Protein phosphatase” was found responsible for the virulence of Neospora caninum. The other genes were accounted for gene expression, vesicular transport, cell signaling, cell proliferation, DNA repair mechanism, and different developmental stages of the protozoon. Therefore, this study finding will provide pivotal information to future aspirants upon Bovine Neosporosis. It will also serve as the baseline information for further studies of the bioinformatics approach to identify other protozoal miRNAs.
‘The Drugs Did For Me What I Couldn’t Do For Myself’: A Qualitative Exploration of the Relationship Between Mental Health and Amphetamine-Type Stimulant (ATS) Use
Authors: Spencer Liam Patrick , Addison Michelle , Alderson Hayley , McGovern William , McGovern Ruth , Kaner Eileen , O’Donnell Amy
Published: December 2021

Substance use and mental ill health constitute a major public health burden, and a key global policy priority is to reduce illicit and other harmful substance use. Amphetamine-type stimulants (ATS) are the second most used class of illicit drugs and a range of mental health issues have been documented amongst users. This paper explores the relationship between mental health and ATS use, through a thematic analysis of qualitative interviews with n  = 18 current and former ATS users in England. The findings are presented by trajectory point of; (1) Initiation of ATS use; (2) continued and increased ATS use and (3) decreased and remitted ATS use. This work helps to develop understanding around the complex and bi-directional relationship between ATS use and mental health. Many ATS users lead chaotic lives and engage in multiple risk behaviours, however there is a need to better understand and conceptualise the dynamic interaction between different individual, social, environment and cultural factors that determine individuals’ mental health and substance use. There is no ‘one size fits all’ approach to prevention and treatment, and these findings highlight the need for more joined-up, tailored and holistic approaches to intervention development.
Understanding Complaints in the Emergency Department
Authors: Abidova Alina , da Silva Pedro Alcântara , Moreira Sérgio
Published: December 2021

The aim of this research is to identify the main determinants of patients’ complaints and potential mediators and moderators in this regard. This research shows that complaints can result from a complex set of processes involving direct, mediating, and moderating effects. Interventions aimed at reducing patients’ complaints should consider specific patient groups and experiences.
Continuous Lower Abdominal Compression as a Therapeutic Intervention in COVID-19 ARDS
Authors: Cupaciu Alexandru , Cohen Vladimir , Dudoignon Emmanuel , Dépret François
Published: December 2021

We report the case of a patient with severe COVID-19 ARDS, suggesting a possible therapeutic intervention by applying a continuous lower abdominal compression. In order to assess ventilation distribution, a lung CT scan was performed with and without lower abdominal compression.
Prediction of nonlinear dynamic coefficients of tilting-pad journal bearings with pad perturbation
Authors: Hojjati Mohammad , Farzanmehr Seyed Younes , Navaz H. M. , Haddadpour Hassan
Published: December 2021

In this paper, a modified partial derivative method is developed to predict the linear and nonlinear dynamic coefficients of tilting-pad journal bearings with journal and pad perturbation. To this end, Reynolds equation and its boundary conditions along with equilibrium equations of the pad are used. Finite difference, partial derivative method, and perturbation technique have been employed simultaneously for solving these equations. The accuracy of the results is investigated by comparing the linear dynamic coefficients of three types of tilting-pad journal bearings with those published the literature. It is shown that the nonlinear dynamic coefficients depend on Sommerfeld number, eccentricity ratio, and length to diameter ratio. Similar to the case of linear dynamic coefficients of TPJB, it is observed that the eccentricity ratio effects on nonlinear dynamic coefficients are more notable when the eccentricity ratio is higher than 0.8 or less than 0.2.
Themes describing social isolation in family caregivers of people living with dementia: A scoping review
Authors: Lee Joonyup , Baik Sol , Becker Todd D. , Cheon Ji Hyang
Published: December 2021

Introduction

The number of people with dementia has been increasing. Evidence shows that over 16 million family caregivers provide unpaid care for people with dementia. However, family caregivers experience several challenges throughout their caregiving role, including that of social isolation. Although social isolation in people with dementia has been well documented, social isolation in their family caregivers has not received as much scholarly attention. This scoping review sought to address this dearth of research through the following research question: “What are themes, concepts, or constructs that describe social isolation of family caregivers for people living with dementia?”.

Method

An electronic search was conducted in PubMed, PsycInfo, and Scopus, using the following Boolean search phrase: dementia AND “social isolation” AND (caregiver OR carers). Content analysis was conducted to identify relevant themes.

Findings

The initial search yielded 301 studies. Through screening processes, 13 studies were eligible for review. Based on a synthesis of evidence, five themes emerged from the data: disease progression, psychological state, social networks, social supports, and technology.

Discussion

This review demonstrates that caregiving is related to social isolation in family caregivers of people living with dementia. The experience of social isolation was related to the progression of dementia, psychological states, and lack of supports. In contrast, social supports, social networks, and using technology may reduce social isolation. Identifying themes provides policy and practice implications, such as using information and communication technology to create and redefine social networks.
“Touch Me If You Can!”: Individual Differences in Disease Avoidance and Social Touch
Authors: Thiebaut Gaëtan , Méot Alain , Witt Arnaud , Prokop Pavol , Bonin Patrick
Published: December 2021

The threat of diseases varies considerably among individuals, and it has been found to be linked to various proactive or reactive behaviors. In the present studies, we investigated the impact of individual differences in the perceived vulnerability to disease (PVD) on social touch before (Study 1) or during the coronavirus disease 2019 (COVID-19) pandemic (Study 2). We also investigated the influence of personality traits in the covariation between these two dimensions. We found that people who are the most disease-avoidant are also the most reluctant to touching or being touched by others (and this relationship holds when personality traits are taken into account). Interestingly, the association between PVD and social touch increased during the COVID-19 pandemic compared with a few months before. By showing that the fear of contamination has an association with social touch, the findings provide further evidence for the behavioral immune system ( Schaller and Park, 2011 ), a psychological system acting as a first line of defense against pathogens.
Are People More Satisfied with Democracy When They Feel They Won the Election? No
Authors: Daoust Jean-François , Plescia Carolina , Blais André
Published: December 2021

Citizens who voted for a party ending up in government are more satisfied with democracy than those who supported a party that ends up in the opposition. The assumption is that voting for a party that is included in the government produces a perception of having won the election, which increases one’s level of satisfaction with democracy. This (assumed) mediation has never been directly tested. In this research note, we provide the first empirical test of this mediation using data from the Making Electoral Democracy Work project, which includes a question tapping whether the respondent perceives the party she voted for won or lost the election. We do not find support for the mediation hypothesis. We conclude that the meaning of the higher (lower) satisfaction observed among those who voted for a party included in the government (or in the opposition) remains ambiguous. Our research has important implications for the conceptualization of what it means to win or lose an election.
Using Collective Impact to Develop a Community-Led Initiative for Improving Black Infant Mortality
Authors: Yakubu Rauta Aver , Scharff Darcell P. , Gulley Lora , BeLue Rhonda , Enard Kimberly R.
Published: December 2021

The United States has one of the highest infant mortality rates among developed countries. When stratified by race, disparities are more evident: Black infant mortality rates are 2.5 times higher than non-Hispanic white infants. Structural, systemic racism is a contributing cause for these racial disparities. Multisector collaborations focused on a common agenda, often referred to as collective impact, have been used for infant mortality reduction interventions. In addition, community-based participatory approaches have been applied to incorporate those with lived experience related to adverse pregnancy outcomes. This article critically describes the transition of an infant mortality collective impact initiative from being led by a multisector organizational group to being community led over a 5-year period, 2015–2020. A 34-member community leaders group was developed and determined four priorities and corresponding strategies for the initiative. Findings show that community participatory approaches are a way to address racial equity for public health initiatives.
The Psychosocial Adjustment of Kidney Recipients in Canada's Kidney Paired Donation Program
Authors: Bourkas Sophia , Achille Marie
Published: December 2021

Introduction: Kidney paired donation programs have been implemented globally. The involvement of at least 2 donors in these programs might exacerbate recipients’ debt of gratitude and guilt, worries about the donor's health, and worries about graft failure documented by previous studies. However, there is an absence of research on the psychosocial implications of kidney paired donation. This study aimed to provide an in-depth examination of recipients’ experience of kidney paired donation, with a focus on psychosocial adjustment. Methods/Approach: Individual interviews were conducted with 8 recipients who received a transplant through Canada's Kidney Paired Donation program. Data was analyzed using Interpretative Phenomenological Analysis. Findings: Four themes emerged: (a) an emotionally charged relationship with the known donor, (b) optimal distance regulation in the relationship with the anonymous donor, (c) kidney paired donation as a series of ups and downs, and (d) multilayered gratitude. Discussion: Findings are considered in relation to extant literature. Issues relevant to the transplant community's clinical and research efforts to provide kidney recipients responsive care are discussed.
A Multistate Comparison Study of COVID-19 Cases Among Accredited and Nonaccredited Nursing Homes
Authors: Longo Beth A. , Barrett Stacey C. , Schmaltz Stephen P. , Williams Scott C.
Published: December 2021

Widely acknowledged is the disproportionate number of COVID-19 cases among nursing home residents. This observational study examined the relationship between accreditation status and COVID-19 case rates in states where the numbers and proportions of Joint Commission accredited facilities made such comparisons possible (Illinois (IL), Florida (FL), and Massachusetts (MA)). COVID-19 data were accessed from the Centers for Medicare & Medicaid Services (CMS) Nursing Home Compare Public Use File, which included retrospective COVID-19 data submitted by nursing homes to the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network. The outcome variable was the total number of nursing home-identified COVID-19 cases from June 2020 to January 2021. Joint Commission accreditation status was the independent variable. Mediating factors included state, and county-level case rates. Increases in the county rate had a significant association with higher nursing home COVID-19 case rates ( p < .001). After adjusting for county case rates, no differences were observed in the mean group case rates for accredited and nonaccredited nursing homes. However, comparing predicted case rates to actual case rates revealed that accredited nursing homes were more closely aligned with their predicted rates. Performance of the nonaccredited nursing homes was more variable and had proportionally more outliers compared to accredited nursing homes. Community prevalence of COVID-19 is the strongest predictor of nursing home cases. While accreditation status did not have an impact on overall mean group performance, nonaccredited nursing homes had greater variation in performance and a higher proportion of negative outliers. Accreditation was associated with more consistent performance during the COVID-19 pandemic, despite being located in counties with a higher prevalence of COVID-19.
Synthesis of waterborne epoxy resin with diethanolamine-assisted succinimide for improving the strand integrity of polyimide filament
Authors: Yao Yijun , Wang Miao , Wu Hailiang , Shen Yanqin
Published: December 2021

A water-soluble epoxy resin emulsion was synthesized by diethanolamine-assisted succinimide modified epoxy resin (DSEP) and used to reinforce the strand integrity of polyimide filament (PI). FTIR, XPS, and 1H NMR provide an evidence for the succinimide (SI) and diethanolamine (DEA) bonded onto the epoxy resin (EP) structure in the form of C-N-C. The DSEP emulsion shows high storage and dilution stability, with its particle size distribution and PDI of 118∼232 nm and 0.106∼0.638, respectively. Compared with DEA modified EP, DSEP exhibits better strand integrity for PI filament. The breaking strength of PI filament infiltrated by DSEP can reach 2.59 GPa, which is increased by 47.04% than that of PI filament, and is close to that of commercially available water-soluble polyimide resin (2.63 GPa). In addition, the fracture microstructure of PI filament further confirms that DSEP significantly reinforces the aggregation of PI filament. Importantly, there is no wire splitting phenomenon of DSEP reinforced PI filament after more than 200 times of friction. These benefit from the similar material groups of imide ring and benzene ring between DSEP and PI filament structure, as well as the strong hydrogen bonding interaction between them, as further confirmed by FTIR and SEM analysis.
Forum: Challenging Students to Engage Meaningfully Across Ideological Differences
Authors: Harrison Laura M. , Williams-Cumberbatch Helen
Published: December 2021

As college student educators, we notice a pattern of difficulty in our students’ ability to engage meaningfully across ideological differences. In this work, we posit the social media mindset’s penchant for reductive framing and outgroup shaming as a potential diagnosis of the problem. We explore how these tendencies show up in the classroom; we present alternative frameworks for stimulating better conversations across differences. These frameworks include promoting democratic civility (as opposed to niceness), understanding ourselves as works in progress (as opposed to engaging call-out and cancel culture), and creating the conditions for the call-in (as opposed to “ducking diversity”).
A Qualitative Analysis of Mexican-Origin Men’s Knowledge and Cultural Attitudes Toward Non-Alcoholic Fatty Liver Disease and Interest in Risk Reduction
Authors: Villavicencio Edgar A. , Crocker Rebecca M. , Garcia David O.
Published: December 2021

Mexican-origin men are at increased risk of developing non-alcoholic fatty liver disease (NAFLD). The purpose of this qualitative research was to assess Mexican-origin men’s knowledge and cultural attitudes toward NAFLD and their interest in risk reduction. Semi-structured interviews were conducted with 11 Spanish-speaking Mexican-origin men who were considered high-risk of having NAFLD according to transient elastography (FibroScan®) continuous attenuation parameter (CAP) scores (≥280). Audio recordings of these interviews were transcribed and interpreted in their respective language to facilitate data analysis using NVivo 12. A thematic codebook was developed, from which the research team identified emerging themes. Findings demonstrated limited knowledge about NAFLD and in general chronic liver disease among Mexican-origin men. Cultural attitudes appeared to both enhance and mitigate their perceived risk for NAFLD. Interviews also revealed high interest levels for reducing NAFLD risk, with family and loved ones acting as the main motivators for engagement in healthier behaviors. Inclination toward family-based interventions was reported as a subject of interest for this high-risk population. This qualitative study suggests that the development of a NAFLD-specific intervention approach for Mexican-origin men may be feasible and should consider a familial and cultural context centered in improving lifestyle health behaviors.
Factors Associated With Severity of Cubital Tunnel Syndrome at Presentation
Authors: Zhang Dafang , Earp Brandon E. , Homer Scott H. , Blazar Philip
Published: December 2021

Background:

The outcomes of cubital tunnel syndrome surgery are affected by preoperative disease severity. The aim of this study was to identify factors associated with clinical and electrodiagnostic severity of cubital tunnel syndrome at presentation.

Methods:

We retrospectively identified 213 patients with electrodiagnostically confirmed cubital tunnel syndrome who underwent cubital tunnel surgery from July 2008 to June 2013. Our primary response variable was clinical cubital tunnel syndrome severity assessed by the McGowan grade. Our secondary response variables were sensory nerve action potential (SNAP) recordability, presence of fibrillations, and motor nerve conduction velocities (CVs) in the abductor digiti minimi (ADM) and first dorsal interosseous (FDI). Bivariate analysis was used to screen for factors associated with disease severity; significant variables were selected for multivariable regression analysis.

Results:

Older age was associated with higher McGowan grade and diabetes mellitus was associated with unrecordable SNAPs on bivariate analysis. No other variables met inclusion criteria for multivariable regression analysis for McGowan grade or unrecordable SNAPs. Multivariable regression analysis showed older age and higher Distressed Communities Index (DCI) to be associated with decreased motor nerve CVs in ADM. Multivariable regression analysis showed higher body mass index (BMI) and higher DCI to be associated with decreased motor nerve CVs in FDI. No variable was associated with the presence of fibrillations.

Conclusions:

A subset of patients with cubital tunnel syndrome may benefit from earlier referral for hand surgery evaluation and earlier surgery. Older patients, with higher BMI, with diabetes mellitus, and with economic distress are at higher risk for presentation with more severe disease.
Wide Awake Local Anesthesia No Tourniquet Technique in Hand Surgery: The Patient Experience
Authors: Pina Matthew , Cusano Antonio , LeVasseur Matthew R. , Olivieri-Ortiz Rafael , Ferreira Joel , Parrino Anthony
Published: December 2021

Background:

We attempted to evaluate patient satisfaction and overall experience during wide awake, local anesthesia, with no tourniquet (WALANT) hand surgery and quantify surgery-related outcomes.

Methods:

We conducted a retrospective analysis of patient demographics, comorbidities, and patient reported outcomes via Single Assessment Numeric Evaluation (SANE) scores collected pre- and postoperatively of patients undergoing WALANT surgery by the 2 participating senior authors. A solution of 1% lidocaine with 1:100,000 epinephrine was used by 1 surgeon, while the other used a 1:1 ratio of 1% lidocaine with 1:100,000 epinephrine and 0.5% bupivacaine for local anesthetic injection. Patients were administered a postoperative survey to assess patient experience, including anxiety and pain levels, and overall satisfaction in the perioperative period.

Results:

Overall, 97.7% of patients indicated that they would undergo a WALANT-style surgery if indicated in the future, 70.5% ate the day of surgery, and a total of 39.1% of patients reported driving to and from surgery. Postoperative SANE scores increased as compared with preoperative scores across all patients. The use of combination 1% lidocaine with 1:100,000 epinephrine and 0.5% bupivacaine was associated with lower intraoperative and postoperative visual analog scale pain scores.

Conclusions:

WALANT hand surgery was generally well tolerated with excellent surgical outcomes. Patients reported ease of preparation for surgery, faster recovery, and lack of anesthetic side effects as the main benefits of wide-awake surgery. Combination use of lidocaine and bupivacaine may be better than lidocaine alone with respect to pain control in the initial recovery period.
A Description–Experience Framework of the Psychology of Risk
Authors: Hertwig Ralph , Wulff Dirk U.
Published: December 2021

The modern world holds countless risks for humanity, both large-scale and intimately personal—from cyberwarfare, pandemics, and climate change to sexually transmitted diseases and drug use and abuse. Many risks have prompted institutional, regulatory, and technological countermeasures, the success of which depends to some extent on how individuals learn about the risks in question. We distinguish between two powerful but imperfect teachers of risk. First, people may learn by consulting symbolic and descriptive material, such as warnings, statistics, and images. More often than not, however, a risk’s fluidity defies precise description. Second, people may learn about risks through personal experience. Responses to risk can differ systematically depending on whether people learn through one mode, both, or neither. One reason for these differences—and by no means the only reason—is the discrepancy in the cognitive impact that rare events (typically the risk event) and common events (typically the nonoccurrence of the risk event) have on the decision maker. We propose a description–experience framework that highlights not only the impact of each mode of learning but also the effects of their interplay on individuals’ and collectives’ responses to risk. We outline numerous research questions and themes suggested by this framework.
Surgical treatment of metastatic VIPoma: a case report
Authors: Azizian Azadeh , König Alexander , Hartmann Amelie , Schuppert Frank , Seif Amir Hosseini Ali , Kitz Julia , Ghadimi Michael
Published: December 2021

VIPoma, a neuroendocrine tumour mostly occurring in the human pancreas and producing high levels of vasoactive intestinal peptide, is a rare disease that presents with a wide spectrum of symptoms, including intense diarrhoea, hypokalaemia, and cardiac complications, with life-threatening consequences. In most cases, metastatic lesions are present at VIPoma diagnosis. Treatment options include symptomatic therapy, chemotherapy, radiation and surgery. Due to its low incidence, there are no evidence-based therapy recommendations to date. Here, we present a case of a 39-year-old woman with severe symptoms due to VIPoma of the pancreas with diffuse hepatic metastasis, who underwent simultaneous resection of the primary tumour, extensive liver resection and radiofrequency ablation. The patient was released in good health and was recurrence-free during 12 months surveillance. According to the existing literature and our own experience, surgical procedures appear to be the most promising therapy option for cases with diffuse hepatic metastasis, offering patients relief from their symptoms and (chemo)therapy-free time.
Sesamol Supplementation Mitigates Isoproterenol-Induced Cardiac Toxicity in Rats by Stabilizing Cardiac Mitochondrial and Lysosomal Enzymes
Authors: Vennila Lakshmanan , Pugalendi Kodukkur Viswanathan , Radhiga Thangaiyan
Published: December 2021

The current investigation was intended to evaluate the antimyocardial ischemic effects of sesamol on lactate dehydrogenase (LDH) isoenzymes, DNA damage, and mitochondrial and lysosomal enzyme activities in isoproterenol (ISO)-induced myocardial infarction (MI) in male albino Wistar strain rats. Rats that received ISO (85 mg/kg body weight (B.W) subcutaneously) for the first 2 consecutive days showed significant reduction in the activities of tricarboxylic acid (TCA) cycle enzymes (isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, malate dehydrogenase, and succinate dehydrogenase) and respiratory chain enzymes (cytochrome c oxidase and nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase) in the heart mitochondria. The activities of the lysosomal enzymes (α-and β-glucosidases, α and β-galactosidases, β-glucuronidase and β-N-acetyl glucosaminidase and cathepsin-B and cathepsin-D) were increased significantly in the heart homogenate of ISO-induced MI rats. ISO injection also increased the % of tail DNA, tail length, and tail moment and decreased the % of head DNA. Pretreatment with sesamol (50 mg/kg B.W) every day for a period of 9 days prevented the above abnormalities induced by ISO. In conclusion, it can be inferred that administration of sesamol has a potent beneficial role against ISO-induced damage to the mitochondria, lysosomes, and DNA, thereby preventing MI.
Rousing Collective Compassion at Societal Level: Lessons from Newspaper Reports on Asian Tsunami in India
Authors: Poonamallee Latha , Joy Simy
Published: December 2021

Compassion involves feeling others’ pain, being moved by it, and acting in a manner that eases the suffering. Originally conceptualized as an individual-level phenomenon, organization scholars extend the concept to the organizational level as ‘collective compassion’ and call for expanding it to societal levels. We note that the dynamics of rousing collective compassion, however, may be different in organizational as opposed to societal contexts: the observers and the sufferers are in personal or close contact in the former context, whereas mass media is often the bridge connecting both in the latter. In this paper, we seek to deepen the understanding of the dynamics of rousing collective compassion at the societal level, by delineating the elements in media reports that can feed into compassion rousing processes. Based on a thematic analysis of newspaper reports from India on the first seven days after the Asian Tsunami, we identify four groups of elements—‘attention drawing elements’, ‘cognitive framing elements’, ‘affective arousal elements’ and ‘behaviour modelling elements’—which can respectively influence each of the four individual compassion subprocesses, namely noticing, appraising, feeling and acting. We offer a conceptual model to comprehensively represent collective compassion rousing at societal level, integrating our findings with prior research.
Metal failure and nonunion at L5-S1 after long instrumented fusion distal to pelvis for adult spinal deformity: Anterior versus transforaminal interbody fusion
Authors: Park Se-Jun , Park Jin-Sung , Lee Chong-Suh , Lee Keun-Ho
Published: December 2021

Purpose

Pseudoarthrosis and metal failure at L5-S1 following long fusion surgery for adult spinal deformity (ASD) remain major issues. Few studies report on which anterior column support technique is better in terms of achieving fusion and avoiding metal failures. Our study aimed to evaluate the fusion status and metal failure rate at L5-S1 after anterior lumbar interbody fusion (ALIF) versus transforaminal lumbar interbody fusion (TLIF).

Methods

The study population included patients aged >50 years who underwent surgery for ASD. Anterior column supports at L5-S1 using ALIF and TLIF were compared with ≥ 2-year follow-up. Fusion status on 2-year computed tomography (CT) scan, metal failure, visual analog scale (VAS), and Oswestry disability index (ODI) were evaluated.

Results

98 patients were included in this study (53 ALIF group and 45 TLIF group). We achieved solid fusion on 2-year CT scans in 88.9% and 69.8% patients in the TLIF and ALIF group, respectively. Metal failure developed in nine (17.0%) and six (13.3%) patients in the ALIF and TLIF group, respectively. The most common failure type was unilateral L5-S1 rod fracture (7 and five patients in the ALIF and TLIF group, respectively). Only one patient with bilateral rod fractures in the ALIF group required revision surgery. There were no differences in the VAS and ODI scores at the last follow-up.

Conclusions

TLIF showed a better fusion rate than ALIF at L5-S1 after long instrumented fusion for ASD. However, the capacity to restore sagittal parameters was greater in the ALIF group. There were no differences between the groups regarding metal failure rate, revision surgery, or clinical outcomes.
Demographic analysis of knee dislocation: A rare mechanism of injury
Authors: Bozkurt Ibrahim , Ozdemir Guzelali , Bingol Olgun , Kilic Enver , Korucu Alperen , Ocguder Durmus Ali
Published: December 2021

Purpose

The aim of this study was to present to the literature a rare injury mechanism that causes knee dislocation (KD) and describe its characteristics.

Methods

A retrospective review of patients with KD who were treated between January 2014 and December 2019 at our hospital was performed. Patients with KD due to rotavator machine injury were included in Group 1 and all patients with KD due to other etiological reasons were included in Group 2. Patients’ age, gender, side, injury mechanism, time to surgery, length of stay (LOS), operation time, follow-up time, neurological injury status, vascular injury status, open injury status, and surgical interventions were evaluated.

Results

A total of 34 patients were evaluated in the study. There was no statistically significant difference between the groups in terms of age, gender, side, or follow-up time ( p = .915, p = 1.000, p = .682, p = .374, respectively). However, LOS and time to surgery were statistically significantly longer in Group 1 ( p = .037, p = .010, respectively). Moreover, neurovascular damage was statistically significantly more common in Group 1.

Conclusion

As a rare injury mechanism for KD, rotavator machine injuries cause more neurovascular injuries in patients compared to other injury mechanisms and increase the time to surgery and LOS due to preoperative soft tissue damage.
Does posterior cruciate ligament sacrifice influence dynamic balance after total knee arthroplasty? Comparison of cruciate-retaining and cruciate-substituting designs in bilaterally operated patients
Authors: Guven Mehmet Fatih , Karaismailoglu Bedri , Kara Eyyup , Ahmet Serpil Hulya , Guler Cevaydin , Tok Okan , Ozsahin Mahmut Kursat , Aydıngöz Önder
Published: December 2021

Purpose

This study aimed to evaluate whether the posterior cruciate ligament sacrifice during total knee arthroplasty (TKA) has any effect on postoperative standing balance or not.

Methods

The patients who underwent bilateral TKA with either CR or PS design were analyzed. 30 patients (10 PS, 20 CR) were included for the final analysis. TKA designs were compared in terms of Lysholm score, range of motion, and balance characteristics including somatosensorial, vestibular, and visual balance scales, adaptation, limits of stability, and weight-bearing/squat tests by computerized dynamic posturography.

Results

The mean follow-up time was 59 months for CR, 49 months for PS group. The average Lysholm score values were 94 for CR and 95 for PS group, indicating functionally similar patient groups. The average knee flexion was found significantly higher in PS group (114°) compared to CR group (102°) ( p = 0.009). In the CR group, motor adaptation tests (toes up/toes down) were found to be better ( p = 0.034). In the on-axis velocity parameter (linear goal orientation) of limits of stability test, PS group patients were found to be more successful ( p = 0.035).

Conclusions

The use of CR implants can be recommended in patients with a high risk of falling since they provide better motor adaptation providing rapid reactions to rapid surface changes. Better linear goal orientation in PS group, providing a faster movement in an intended direction, should be considered when planning the ideal implant for the patients with relevant activities.
Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
Authors: DeClercq Madeleine G. , Fiorentino Alyson M. , Lengel Haylie A. , Ruzbarsky Joseph J. , Robinson Sara K. , Oberlohr Verena T. , Whitney Kaitlyn E. , Millett Peter J. , Huard Johnny
Published: December 2021

Background:

The therapeutic efficacy of orthobiologic therapies for rotator cuff repair is difficult to evaluate owing to reporting inconsistences. In response, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guidelines were developed to ensure standard reporting on orthobiologic therapies.

Purpose:

To systematically review clinical studies evaluating platelet-rich plasma (PRP) for full-thickness rotator cuff repair and adherence to MIBO guidelines.

Study Design:

Scoping review; Level of evidence, 4.

Methods:

A search was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using PubMed, EMBASE, and the Cochrane Library databases. Inclusion criteria were clinical studies reporting on rotator cuff tears (≥1 cm) surgically repaired with PRP. Patient demographics, biologic intervention, and adherence to the MIBO guidelines were systematically reviewed.

Results:

A total of 19 studies (1005 patients) were included in this review. Across all studies, 58.5% of the MIBO checklist items for PRP were reported. Out of 47 checklist items, 19 were reported in over 85% of studies, whereas 22 were reported in less than half of studies. Details of whole-blood processing and characteristics, as well as PRP processing and characteristics, were reported inconsistently, and no study provided adequate information to enable the precise replication of preparation protocols for PRP.

Conclusion:

This systematic review highlights the current reporting deficiencies within the scientific literature of important variables for evaluating PRP for full-thickness rotator cuff repair. There was widespread variability among published studies that evaluate PRP for this application and, more specifically, studies were limited by inconsistent universal reporting of whole-blood and PRP processing and postprocessing characteristics. To improve our understanding of biologic efficacy and to promote repeatability, stricter adherence to the MIBO guidelines is necessary. We propose that the checklist limitations be addressed and that modification of the MIBO guidelines be considered to improve the reporting of individual components within certain categories.
Not Using a Tourniquet May Reduce the Incidence of Asymptomatic Deep Venous Thrombosis After ACL Reconstruction: An Observational Study
Authors: Nagashima Masaki , Takeshima Kenichiro , Origuchi Nobuto , Sasaki Ryo , Okada Yoshifumi , Otani Toshiro , Ishii Ken
Published: December 2021

Background:

Deep venous thrombosis (DVT) and pulmonary embolism are serious potential complications after anterior cruciate ligament reconstruction (ACLR). Little is known about the influence of tourniquet use on the incidence of DVT after ACLR.

Purpose:

To compare the incidence of DVT after ACLR with and without the use of a tourniquet.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Between November 2018 and May 2020, a total of 60 consecutive ACLRs in 60 patients, including 7 revision surgeries, were performed without tourniquet use at our hospital and were enrolled in this study (T– group). In addition, 55 consecutive ACLRs in 55 patients, including 10 revision surgeries, were performed with tourniquet use between April 2017 and September 2018 and were enrolled as the control group (T+ group). DVT was diagnosed using ultrasonography of both legs performed preoperatively and at postoperative week 1. The incidence of postoperative DVT was compared between the T– and T+ groups. Logistic regression analysis was performed to evaluate the effect of older age (≥40 vs <40 years) and tourniquet use on the occurrence of DVT.

Results:

No DVTs were detected preoperatively. The incidence of postoperative DVT was significantly lower in the T– group compared with the T+ group (1 patient [1.7%] vs 9 patients [16.4%]; P = .005). All patients with DVT were asymptomatic. Although the mean operative time was not significantly different (80.8 minutes in the T+ group vs 78.5 minutes in the T– group; P = .461), the mean blood loss from the drain was significantly lower in the T– group than in the T+ group (149.9 vs 201.9 mL; P < .001). Age ≥40 years and tourniquet use were significantly related to the occurrence of DVT (odds ratio, 8.3 [95% CI, 1.9-36.8]; P = .005; and odds ratio, 8.8 [95% CI, 1.0-75.3]; P = .047, respectively).

Conclusion:

ACLRs performed without tourniquet resulted in a significantly lower incidence of DVT after ACLR and significantly less bleeding from drains. If adequate visibility of the surgical field is obtained, ACLR without tourniquet use may reduce the incidence of DVT.
Treatment of Full-Thickness Acetabular Chondral Flaps During Hip Arthroscopy: Bone Marrow Aspirate Concentrate Versus Microfracture
Authors: Kucharik Michael P. , Abraham Paul F. , Nazal Mark R. , Varady Nathan H. , Eberlin Christopher T. , Meek Wendy M. , Naessig Sara A. , Martin Scott D.
Published: December 2021

Background:

The optimal treatment strategy for patients with full-thickness chondral flaps undergoing hip arthroscopy is controversial.

Purpose:

To compare functional outcomes of patients who underwent bone marrow aspirate concentrate (BMAC) application with those of patients who underwent microfracture.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

This was a retrospective case series of prospectively collected data on patients who underwent arthroscopic acetabular labral repair by 1 surgeon between June 2014 and April 2020. The inclusion criteria for this study were age ≥18 years, preoperative radiographs of the pelvis, arthroscopic acetabular labral repair, exposed subchondral bone with overlying chondral flap seen at the time of hip arthroscopy, microfracture or BMAC to address this lesion, and completed patient-reported outcome measures (PROMs) (International Hip Outcome Tool–33 [iHOT-33], Hip Outcome Score–Activities of Daily Living [HOS-ADL], Hip Outcome Score–Sports Subscale [HOS-Sport], modified Harris Hip Score [mHHS], and visual analog scale [VAS] for pain) at enrollment and 12-month follow-up. Clinical outcomes were assessed using PROM scores.

Results:

A total of 81 hips with full-thickness chondral flaps were included in this study: 50 treated with BMAC and 31 treated with microfracture. There were no significant differences between groups in age, sex, body mass index, tear size, radiographic osteoarthritis, or radiographic femoroacetabular impingement. In the BMAC cohort, all PROM scores improved significantly from preoperatively to follow-up: 41.7 to 75.6 for iHOT-33, 67.6 to 91.0 for HOS-ADL, 41.5 to 72.3 for HOS-Sport, 59.4 to 87.2 for mHHS, and 6.2 to 2.2 for VAS pain ( P < .001 for all). In the microfracture cohort, the score improvements were 48.0 to 65.1 for iHOT-33 ( P = .001), 80.5 to 83.3 for HOS-ADL ( P = .275), 59.2 to 62.4 for HOS-Sport ( P = .568), 70.4 to 78.3 for mHHS ( P = .028), and 4.9 to 3.6 for VAS pain ( P = .036). Regarding clinically meaningful outcomes, 77.6% of the BMAC group and 50.0% of the microfracture group met the minimal clinically important difference for iHOT-33 at the 12-month follow-up ( P = .013).

Conclusion:

Patients with full-thickness chondral flaps at the time of hip arthroscopy experienced greater improvements in functional outcome scores at the 12-month follow-up when treated with BMAC as opposed to microfracture.
Project Management Training in Schools and Programs of Public Health in the United States
Authors: Haynes Eboni E. , Gwynn Melanie , Momodu Oluwatosin , Olatosi Bankole
Published: December 2021

Background. Little is known about the use of project management in public health research and practice in the U.S. Research from other countries supports the use of project management (PM) principles to successfully manage public health programs and research, prevent delays, and reduce costs. However, knowledge of PM training in public health schools and programs is limited. This study sought to (1) determine the extent to which PM training is offered to public health students in schools and programs in the U.S. accredited by the Council on Education for Public Health (CEPH), (2) examine why project management courses are not offered, and (3) identify the challenges faced in offering PM courses. Methods. In May 2019, an online survey was distributed to 178 CEPH-accredited schools and programs in public health in the U.S. Thirty-seven percent of schools/programs completed the survey. Results. About 75% of CEPH-accredited schools and programs that responded do not offer PM training. However, respondents deemed PM skills and training critical for the success of students. Primary challenges included lack of qualified instructors, course cost, lack of school/program interest, perceived lack of student interest, and unfamiliarity of the benefits of PM to public health. Discussion. Opportunities abound for administrators to familiarize themselves with the evidence that PM training helps prepare students for the public health workforce. Identifying qualified faculty and funding to support curriculum development, the implementation of PM competencies by CEPH, and additional research are needed to encourage the adoption of PM in schools/programs of public health.
The Rise of One-Person Households
Authors: Cohen Philip N.
Published: December 2021

In this visualization, the author shows the trend in the proportion of households that comprise only one person in 75 countries, representing 73 percent of the world’s population, using national data collected between 1960 and 2019. At the time of the latest observations for each country, the percentage of households that include only one person ranges from 2.6 (Cambodia) to 38 (Switzerland). Europe and the United States have the highest solo living rates, along with two African countries (South Africa and Botswana, both severely affected by the HIV/AIDS epidemic), Israel, Jamaica, and Puerto Rico. In all, 53 of the 75 countries exhibit increases in one-person households, including all European countries. Those with (generally much smaller) declines are disproportionately in Africa and Asia, including China and India.
Qualitative Coding in the Computational Era: A Hybrid Approach to Improve Reliability and Reduce Effort for Coding Ethnographic Interviews
Authors: Li Zhuofan , Dohan Daniel , Abramson Corey M.
Published: December 2021

Sociologists have argued that there is value in incorporating computational tools into qualitative research, including using machine learning to code qualitative data. Yet standard computational approaches do not neatly align with traditional qualitative practices. The authors introduce a hybrid human-machine learning approach (HHMLA) that combines a contemporary iterative approach to qualitative coding with advanced word embedding models that allow contextual interpretation beyond what can be reliably accomplished with conventional computational approaches. The results, drawn from an analysis of 87 human-coded ethnographic interview transcripts, demonstrate that HHMLA can code data sets at a fraction of the effort of human-only strategies, saving hundreds of hours labor in even modestly sized qualitative studies, while improving coding reliability. The authors conclude that HHMLA may provide a promising model for coding data sets where human-only coding would be logistically prohibitive but conventional computational approaches would be inadequate given qualitative foci.
Meniscal Root Repair
Authors: Matthews John R. , Paul Ryan W. , Hammoud Sommer
Published: December 2021

Background:

Meniscal root tears typically result from a hyperflexion/squatting injury or are in conjunction with ligamentous knee injury. Once a complete tear occurs, the meniscus is unable to convert axial loads to transverse hoop stresses which result in increased tibiofemoral contact pressure and osteoarthritis. The goal of a meniscal root repair is to anatomically reattach the meniscal root to the tibia plateau. Complete and partial healing occurs in over 93% of cases with retear rates ranging from 0% to 7%.

Indications:

We present a case of a highly active 21-year-old male collegiate soccer play that sustained a medial meniscal root tear after slipping on ice.

Technique:

An anatomic medial meniscal root repair was performed using a transtibial guide and 2 loop sutures tied over a button.

Results:

Full anatomic footprint coverage was able to be achieved intraoperatively and gentle range of motion from 0 to 90° of flexion did not result in gap formation.

Discussion/Conclusion:

Successful outcomes with full anatomic footprint coverage of the medial meniscal root can be achieved with 2-loop suture button configuration.