bluuebunny/crossref_metadata_2025 huggingface dataset:
Process Parameter Optimization of Extrusion-Based 3D Metal Printing Utilizing PW–LDPE–SA Binder System
Authors: Ren Luquan , Zhou Xueli , Song Zhengyi , Zhao Che , Liu Qingping , Xue Jingze , Li Xiujuan
Published: March 2017

Recently, with a broadening range of available materials and alteration of feeding processes, several extrusion-based 3D printing processes for metal materials have been developed. An emerging process is applicable for the fabrication of metal parts into electronics and composites. In this paper, some critical parameters of extrusion-based 3D printing processes were optimized by a series of experiments with a melting extrusion printer. The raw materials were copper powder and a thermoplastic organic binder system and the system included paraffin wax, low density polyethylene, and stearic acid (PW–LDPE–SA). The homogeneity and rheological behaviour of the raw materials, the strength of the green samples, and the hardness of the sintered samples were investigated. Moreover, the printing and sintering parameters were optimized with an orthogonal design method. The influence factors in regard to the ultimate tensile strength of the green samples can be described as follows: infill degree > raster angle > layer thickness. As for the sintering process, the major factor on hardness is sintering temperature, followed by holding time and heating rate. The highest hardness of the sintered samples was very close to the average hardness of commercially pure copper material. Generally, the extrusion-based printing process for producing metal materials is a promising strategy because it has some advantages over traditional approaches for cost, efficiency, and simplicity.
Protective Effects of Fucoidan on Aβ25–35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice
Authors: Wei Hengyun , Gao Zixiang , Zheng Luping , Zhang Cuili , Liu Zundong , Yang Yazong , Teng Hongming , Hou Lin , Yin Yuling , Zou Xiangyang
Published: March 2017

Alzheimer’s disease (AD) is a chronic neurodegenerative disease which contributes to memory loss and cognitive decline in the elderly. Fucoidan, extracted from brown algae, is a complex sulfated polysaccharide and potential bioactive compound. In this study, we investigated whether fucoidan protects PC12 cells from apoptosis induced by a combination of beta-amyloid 25–35 (Aβ25–35) and d-galactose (d-Gal), and improves learning and memory impairment in AD model mice. The results indicated that fucoidan could inhibit the release of cytochrome c from the mitochondria to cytosol and activation of caspases, and increase the expression of apoptosis inhibitor proteins (IAPs), including livin and X-linked IAP (XIAP) in PC12 cells damaged by Aβ25–35 and d-Gal-induction. Fucoidan reversed the decreased activity of acetylcholine (ACh) and choline acetyl transferase (ChAT), as well as the increased activity of acetylcholine esterase (AChE), in AD model mice induced by infusion of d-Gal. Furthermore, fucoidan improved antioxidant activity in vitro and in vivo by activation of superoxide dismutase (SOD) and glutathione (GSH). These results suggested that fucoidan could protect PC12 cells from apoptosis and ameliorate the learning and memory impairment in AD model mice, which appeared to be due to regulating the cholinergic system, reducing oxidative stress, and inhibiting the caspase-dependent apoptosis pathway.
Tip-Based Nanofabrication for Scalable Manufacturing
Authors: Hu Huan , Kim Hoe , Somnath Suhas
Published: March 2017

Tip-based nanofabrication (TBN) is a family of emerging nanofabrication techniques that use a nanometer scale tip to fabricate nanostructures. In this review, we first introduce the history of the TBN and the technology development. We then briefly review various TBN techniques that use different physical or chemical mechanisms to fabricate features and discuss some of the state-of-the-art techniques. Subsequently, we focus on those TBN methods that have demonstrated potential to scale up the manufacturing throughput. Finally, we discuss several research directions that are essential for making TBN a scalable nano-manufacturing technology.
Immune Response to Coccidioidomycosis and the Development of a Vaccine
Authors: Castro-Lopez Natalia , Hung Chiung-Yu
Published: March 2017

Coccidioidomycosis is a fungal infection caused by Coccidioides posadasii and Coccidioides immitis. It is estimated that 150,000 new infections occur in the United States each year. The incidence of this infection continues to rise in endemic regions. There is an urgent need for the development of better therapeutic drugs and a vaccine against coccidioidomycosis. This review discusses the features of host innate and adaptive immune responses to Coccidioides infection. The focus is on the recent advances in the immune response and host-pathogen interactions, including the recognition of spherules by the host and defining the signal pathways that guide the development of the adaptive T-cell response to Coccidioides infection. Also discussed is an update on progress in developing a vaccine against these fungal pathogens.
Valorization of Phosphorus Secondary Raw Materials by Acidithiobacillus ferrooxidans
Authors: Wyciszkiewicz Małgorzata , Saeid Agnieszka , Malinowski Przemysław , Chojnacka Katarzyna
Published: March 2017

This paper presents the possibility of producing phosphorus fertilizers through Acidithiobacillus ferrooxidans utilization in secondary raw materials solubilization. Phosphorus was obtained from the bones of poultry and fish as well as from Morocco phosphorite. Four doses of poultry bones and fish bones were used in the experiment (2, 4, 10 and 20 g/L) and two doses (2 and 4 g/L) of phosphorite were also used. The experimenters measured the final pH, which increased in proportion to the increase in the number of poultry bone doses, whereas in the case of fish bones it decreased in proportion to the increase in the number of fish bone doses. Only in the case of phosphorite, where 10 g/L were used, there was a slight increase in pH during solubilization observed. The highest phosphorus concentration of 1.9% (expressed as P2O5) was found for the solubilization performed on fish bones with the highest dose (20 g/L). The formulation obtained in this study meets the necessary requirements for use as a bio-fertilizer because of the relatively low content of P2O5 and the low content of toxic elements. The results confirm the utilization of Acidithiobacillus ferrooxidans in the biosolubilization of phosphorus renewable raw materials that can alleviate the problem of the world’s depleting phosphorite deposits.
Overcoming Dietary Assessment Challenges in Low-Income Countries: Technological Solutions Proposed by the International Dietary Data Expansion (INDDEX) Project
Authors: Coates Jennifer , Colaiezzi Brooke , Bell Winnie , Charrondiere U. , Leclercq Catherine
Published: March 2017

An increasing number of low-income countries (LICs) exhibit high rates of malnutrition coincident with rising rates of overweight and obesity. Individual-level dietary data are needed to inform effective responses, yet dietary data from large-scale surveys conducted in LICs remain extremely limited. This discussion paper first seeks to highlight the barriers to collection and use of individual-level dietary data in LICs. Second, it introduces readers to new technological developments and research initiatives to remedy this situation, led by the International Dietary Data Expansion (INDDEX) Project. Constraints to conducting large-scale dietary assessments include significant costs, time burden, technical complexity, and limited investment in dietary research infrastructure, including the necessary tools and databases required to collect individual-level dietary data in large surveys. To address existing bottlenecks, the INDDEX Project is developing a dietary assessment platform for LICs, called INDDEX24, consisting of a mobile application integrated with a web database application, which is expected to facilitate seamless data collection and processing. These tools will be subject to rigorous testing including feasibility, validation, and cost studies. To scale up dietary data collection and use in LICs, the INDDEX Project will also invest in food composition databases, an individual-level dietary data dissemination platform, and capacity development activities. Although the INDDEX Project activities are expected to improve the ability of researchers and policymakers in low-income countries to collect, process, and use dietary data, the global nutrition community is urged to commit further significant investments in order to adequately address the range and scope of challenges described in this paper.
Glacier Mass Loss during the 1960s and 1970s in the Ak-Shirak Range (Kyrgyzstan) from Multiple Stereoscopic Corona and Hexagon Imagery
Authors: Goerlich Franz , Bolch Tobias , Mukherjee Kriti , Pieczonka Tino
Published: March 2017

Comprehensive research on glacier changes in the Tian Shan is available for the current decade; however, there is limited information about glacier investigations of previous decades and especially before the mid 1970s. The earliest stereo images from the Corona missions were acquired in the 1960s but existing studies dealing with these images focus on single glaciers or small areas only. We developed a workflow to generate digital terrain models (DTMs) and orthophotos from 1964 Corona KH-4 for an entire mountain range (Ak-Shirak) located in the Central Tian Shan. From these DTMs and orthoimages, we calculated geodetic mass balances and length changes in comparison to 1973 and 1980 Hexagon KH-9 data. We found mass budgets between −0.4 ± 0.1 m·w.e.a−1 (1964–1980) and −0.9 ± 0.4 m·w.e.a−1 (1973–1980) for the whole region and individual glaciers. The length changes, on the other hand, vary heterogeneously between +624 ± 18 m (+39.0 ± 1.1 m·a−1) and −923 ± 18 m (−57.7 ± 1.1 m·a−1) for 1964–1980. An automation of the processing line can successively lead to region-wide Corona data processing allowing the analysis and interpretation of glacier changes on a larger scale and supporting a refinement of glacier modelling.
UAV-Based Oblique Photogrammetry for Outdoor Data Acquisition and Offsite Visual Inspection of Transmission Line
Authors: Jiang San , Jiang Wanshou , Huang Wei , Yang Liang
Published: March 2017

Regular inspection of transmission lines is an essential work, which has been implemented by either labor intensive or very expensive approaches. 3D reconstruction could be an alternative solution to satisfy the need for accurate and low cost inspection. This paper exploits the use of an unmanned aerial vehicle (UAV) for outdoor data acquisition and conducts accuracy assessment tests to explore potential usage for offsite inspection of transmission lines. Firstly, an oblique photogrammetric system, integrating with a cheap double-camera imaging system, an onboard dual-frequency GNSS (Global Navigation Satellite System) receiver and a ground master GNSS station in fixed position, is designed to acquire images with ground resolutions better than 3 cm. Secondly, an image orientation method, considering oblique imaging geometry of the dual-camera system, is applied to detect enough tie-points to construct stable image connection in both along-track and across-track directions. To achieve the best geo-referencing accuracy and evaluate model measurement precision, signalized ground control points (GCPs) and model key points have been surveyed. Finally, accuracy assessment tests, including absolute orientation precision and relative model precision, have been conducted with different GCP configurations. Experiments show that images captured by the designed photogrammetric system contain enough information of power pylons from different viewpoints. Quantitative assessment demonstrates that, with fewer GCPs for image orientation, the absolute and relative accuracies of image orientation and model measurement are better than 0.3 and 0.2 m, respectively. For regular inspection of transmission lines, the proposed solution can to some extent be an alternative method with competitive accuracy, lower operational complexity and considerable gains in economic cost.
Non-Destructive Detection of Wire Rope Discontinuities from Residual Magnetic Field Images Using the Hilbert-Huang Transform and Compressed Sensing
Authors: Zhang Juwei , Tan Xiaojiang , Zheng Pengbo
Published: March 2017

Electromagnetic methods are commonly employed to detect wire rope discontinuities. However, determining the residual strength of wire rope based on the quantitative recognition of discontinuities remains problematic. We have designed a prototype device based on the residual magnetic field (RMF) of ferromagnetic materials, which overcomes the disadvantages associated with in-service inspections, such as large volume, inconvenient operation, low precision, and poor portability by providing a relatively small and lightweight device with improved detection precision. A novel filtering system consisting of the Hilbert-Huang transform and compressed sensing wavelet filtering is presented. Digital image processing was applied to achieve the localization and segmentation of defect RMF images. The statistical texture and invariant moment characteristics of the defect images were extracted as the input of a radial basis function neural network. Experimental results show that the RMF device can detect defects in various types of wire rope and prolong the service life of test equipment by reducing the friction between the detection device and the wire rope by accommodating a high lift-off distance.
Sustainable Materialisation of Responsive Architecture
Authors: Holstov Artem , Farmer Graham , Bridgens Ben
Published: March 2017

Natural organisms which employ inherent material properties to enable a passive dynamic response offer inspiration for adaptive bioclimatic architecture. This approach allows a move away from the technological intensity of conventional “smart” building systems towards a more autonomous and robust materially embedded sensitivity and climatic responsiveness. The actuation mechanisms of natural responsive systems can be replicated to produce artificial moisture-sensitive (hygromorphic) composites with the response driven by hygroexpansion of wood. The work presented here builds on previous research on lab-scale material development, to investigate in detail the applicability of wood-based hygromorphic materials for large-scale external applications. The suitability of different material production techniques and viability of potential applications is established through a detailed programme of experimentation and the first one-year-long durability study of hygromorphic wood composites in full weathering conditions. These results provide the basis for the design of an optimised responsive cladding system. The opportunities and challenges presented by building integration and architectural functionalisation of responsive wood composites are discussed based on a hierarchy of application typologies including functional devices and components, performance-oriented adaptive systems, the value of aesthetic and spatial experience and place-specific contextual integration. The design of the first full-scale building application of hygromorphic wood composites is presented.
Spatial and Temporal Variability of Soil Respiration between Soybean Crop Rows as Measured Continuously over a Growing Season
Authors: Wang Xiaohan , Ren Tusheng
Published: March 2017

An improved understanding of temporal and spatial variations in soil respiration is essential for measuring soil CO2 effluxes accurately. In this study, a field experiment was conducted to investigate the spatial and temporal variability of soil respiration between adjacent crop rows in a soybean (Glycine max L.) field. Soil CO2 concentration, water content, and temperature at a 7.5 cm depth were recorded continuously at 0 cm, 12 cm, 24 cm, and 35 cm from the plant row during the growing season. Root biomass at the corresponding locations was collected from the 0 to 10 cm and 10 to 20 cm soil layers at three growth stages. Seasonal CO2 efflux data showed that the minimum value appeared at the seeding stage, increased gradually, reached the maximum at the flowering and grain-filling stages, and then dropped steadily at the mature stage. Within a growth stage, CO2 effluxes related positively to soil temperature, but negatively to soil water content. In the early and vigorous growing stages of soybean crop, soil respiration showed apparent diurnal variations, and was most significant at the crop row location. Except for the seeding stage, CO2 effluxes at the crop row were larger than that of other locations, and effluxes at 35 cm from the row were representative of the mean CO2 efflux between adjacent rows. We concluded that the spatial heterogeneity of CO2 efflux between crop rows should be taken into consideration when measuring soil respiration in agricultural ecosystems.
Two-Way Multi-Antenna Relaying with Simultaneous Wireless Information and Power Transfer
Authors: Srivantana Thanaphat , Maichalernnukul Kiattisak
Published: March 2017

In this paper, we propose various kinds of two-way multi-antenna relaying with simultaneous wireless information and power transfer (SWIPT) and investigate their performance. Specifically, we first consider a two-way relay network where two single-antenna end nodes communicate with each other through a multi-antenna relay node that is energy constrained. This relay node harvests energy from the two end nodes and use the harvested energy for forwarding their information. Six relaying schemes that support the considered network then build on the power splitting-based relaying and time switching-based relaying protocols. The average bit error rates of these schemes are evaluated and compared by computer simulations considering several network parameters, including the number of relay antennas, power splitting ratio, and energy harvesting time. Such evaluation and comparison provide useful insights into the performance of SWIPT-based two-way multi-antenna relaying.
Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hemolysin to Hemolytic Activity and Ion-Channel Opening
Authors: Kurehong Chattip , Kanchanawarin Chalermpol , Powthongchin Busaba , Prangkio Panchika , Katzenmeier Gerd , Angsuthanasombat Chanan
Published: March 2017

The Bordetella pertussis CyaA-hemolysin (CyaA-Hly) domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion-channel formation in planar lipid bilayers (PLBs). Here, net-charge variations in the pore-lining helix of thirteen related RTX cytolysins including CyaA-Hly were revealed by amino acid sequence alignments, reflecting their different degrees of hemolytic activity. To analyze possible functional effects of net-charge alterations on hemolytic activity and channel formation of CyaA-Hly, specific mutations were made at Gln574 or Glu581 in its pore-lining α3 of which both residues are highly conserved Lys in the three highly active RTX cytolysins (i.e., Escherichia coli α-hemolysin, Actinobacillus pleuropneumoniae toxin, and Aggregatibacter actinomycetemcomitans leukotoxin). All six constructed CyaA-Hly mutants that were over-expressed in E. coli as 126 kDa His-tagged soluble proteins were successfully purified via immobilized Ni2+-affinity chromatography. Both positive-charge substitutions (Q574K, Q574R, E581K, E581R) and negative-charge elimination (E581Q) appeared to increase the kinetics of toxin-induced hemolysis while the substitution with a negatively-charged side-chain (Q574E) completely abolished its hemolytic activity. When incorporated into PLBs under symmetrical conditions (1.0 M KCl, pH 7.4), all five mutant toxins with the increased hemolytic activity produced clearly-resolved single channels with higher open probability and longer lifetime than the wild-type toxin, albeit with a half decrease in their maximum conductance. Molecular dynamics simulations for 50 ns of a trimeric CyaA-Hly pore model comprising three α2-loop-α3 transmembrane hairpins revealed a significant role of the positive charge at both target positions in the structural stability and enlarged diameter of the simulated pore. Altogether, our present data have disclosed functional contributions of positively-charged side-chains substituted at positions Gln574 and Glu581 in the pore-lining α3 to the enhanced hemolytic activity and ion-channel opening of CyaA-Hly that actually mimics the highly-active RTX (repeat-in-toxin) cytolysins.
Effect of the ortho-hydroxy group of salicylaldehyde in the A3 coupling reaction: A metal-catalyst-free synthesis of propargylamine
Authors: Ghosh Sujit , Biswas Kinkar , Bhattacharya Suchandra , Ghosh Pranab , Basu Basudeb
Published: March 2017

The synthesis of propargylamines via A3 coupling mostly under metal-catalyzed procedures is well known. This work invented an unprecedented effect of salicylaldehyde, one of the A3 coupling partners, which could lead to the formation of propargylamine, an important pharmaceutical building block, in the absence of any metal catalyst and under mild conditions. The role of the hydroxy group in ortho position of salicylaldehyde has been explored, which presumably activates the Csp–H bond of the terminal alkyne leading to the formation of propargylamines in good to excellent yields, thus negating the function of the metal catalyst. This observation is hitherto unknown, tested for a variety of salicylaldehyde, amine and acetylene, established as a general protocol, and is believed to be of interest for synthetic chemists from green chemistry.
Remote Hearing Aid Support: The Next Frontier
Authors: Angley Gina P. , Schnittker Jean Anne , Tharpe Anne Marie
Published: March 2017

Background:In an effort to reduce health-care disparities, there has been a recent surge of interest in the remote provision of care. Audiologists have begun to provide screening, diagnostic, and rehabilitative services via telehealth technologies.Purpose:To evaluate the
feasibility and perceived benefits of providing remote hearing aid follow-up appointments in a controlled clinical environment and in participants’ homes.Research Design:A descriptive quasi-experimental study was completed.Study Sample:The study consisted of two phases.
The in-clinic phase included 50 adults with hearing loss who participated in remote hearing aid follow-up appointments at Vanderbilt University Medical Center. A subgroup of 21 adults from the original in-clinic phase plus one additional participant completed the in-home appointments.Data
Collection and Analysis:All participants completed the Montreal Cognitive Assessment and study-designed questionnaires. All participants were asked to install proprietary distance support (DS) client software on a laptop or desktop computer and participate in hearing aid follow-up appointments.Results:The
majority of participants in both groups installed the DS client software with no assistance other than written instructions, and indicated a preference for DS appointments over face-to-face appointments.Conclusion:On average, participants and the study audiologist were satisfied with
remote hearing aid follow-up visits. Additional support might be needed for older patients with little confidence in their ability to interact with technology.
General-relativistic Large-eddy Simulations of Binary Neutron Star Mergers
Authors: Radice David
Published: March 2017

The flow inside remnants of binary neutron star (NS) mergers is expected to be turbulent, because of magnetohydrodynamics instability activated at scales too small to be resolved in simulations. To study the large-scale impact of these instabilities, we develop a new formalism, based on the large-eddy simulation technique, for the modeling of subgrid-scale turbulent transport in general relativity. We apply it, for the first time, to the simulation of the late-inspiral and merger of two NSs. We find that turbulence can significantly affect the structure and survival time of the merger remnant, as well as its gravitational-wave (GW) and neutrino emissions. The former will be relevant for GW observation of merging NSs. The latter will affect the composition of the outflow driven by the merger and might influence its nucleosynthetic yields. The accretion rate after black hole formation is also affected. Nevertheless, we find that, for the most likely values of the turbulence mixing efficiency, these effects are relatively small and the GW signal will be affected only weakly by the turbulence. Thus, our simulations provide a first validation of all existing post-merger GW models.
Discovery of a Satellite of the Large Trans-Neptunian Object (225088) 2007 OR10
Authors: Kiss Csaba , Marton Gábor , Farkas-Takács Anikó , Stansberry John , Müller Thomas , Vinkó József , Balog Zoltán , Ortiz Jose-Luis , Pál András
Published: March 2017

2007 OR10 is currently the third largest known dwarf planet in the trans-Neptunian region, with an effective radiometric diameter of ∼1535 km. It has a slow rotation period of ∼45 hr that was suspected to be caused by tidal interactions with a satellite undetected at that time. Here, we report on the discovery of a likely moon of 2007 OR10, identified on archival Hubble Space Telescope WFC3/UVIS system images. Although the satellite is detected at two epochs, this does not allow an unambiguous determination of the orbit and the orbital period. A feasible 1.5–5.8 · 1021 kg estimate for the system mass leads to a likely 35–100 day orbital period. The moon is about 4.ͫ2 fainter than 2007 OR10 in HST images that corresponds to a diameter of 237 km assuming equal albedos with the primary. Due to the relatively small size of the moon, the previous size and albedo estimates for the primary remains unchanged. With this discovery all trans-Neptunian objects larger than 1000 km are now known to harbor satellites, an important constraint for moon formation theories in the young solar system.
The Risk of Deep Venous Thrombosis and Pulmonary Embolism in Primary Sjögren Syndrome: A General Population-based Study
Authors: Aviña-Zubieta J. Antonio , Jansz Michael , Sayre Eric C. , Choi Hyon K.
Published: March 2017

Objective.

To estimate the future risk and time trends of venous thromboembolism (VTE) in individuals with newly diagnosed primary Sjögren syndrome (pSS) in the general population.

Methods.

Using a population database that includes all residents of British Columbia, Canada, we created a study cohort of all patients with incident SS and up to 10 controls from the general population matched for age, sex, and entry time. We compared incidence rates (IR) of pulmonary embolism (PE), deep vein thrombosis (DVT), and VTE between the 2 groups according to SS disease duration. We calculated HR, adjusting for confounders.

Results.

Among 1175 incident pSS cases (mean age 56.7 yrs, 87.6% women), the IR of PE, DVT, and VTE were 3.9, 2.8, and 5.2 per 1000 person-years (PY), respectively; the corresponding rates in the comparison cohort were 0.9, 0.8, and 1.4 per 1000 PY. Compared with non-SS individuals, the multivariable HR for PE, DVT, and VTE among SS cases were 4.07 (95% CI 2.04–8.09), 2.80 (95% CI 1.27–6.17), and 2.92 (95% CI 1.66–5.16), respectively. The HR matched for age, sex, and entry time for VTE, PE, and DVT were highest during the first year after SS diagnosis (8.29, 95% CI 2.57–26.77; 4.72, 95% CI 1.13–19.73; and 7.34, 95% CI 2.80–19.25, respectively).

Conclusion.

These findings provide population-based evidence that patients with pSS have a substantially increased risk of VTE, especially within the first year after SS diagnosis. Further research into the involvement of monitoring and prevention of VTE in SS may be warranted.
Proteomic Analysis of Sera from Individuals with Diffuse Cutaneous Systemic Sclerosis Reveals a Multianalyte Signature Associated with Clinical Improvement during Imatinib Mesylate Treatment
Authors: Haddon D. James , Wand Hannah E. , Jarrell Justin A. , Spiera Robert F. , Utz Paul J. , Gordon Jessica K. , Chung Lorinda S.
Published: March 2017

Objective.

Imatinib has been investigated for the treatment of systemic sclerosis (SSc) because of its ability to inhibit the platelet-derived growth factor receptor and transforming growth factor-β signaling pathways, which have been implicated in SSc pathogenesis. In a 12-month open-label clinical trial assessing the safety and efficacy of imatinib in the treatment of diffuse cutaneous SSc (dcSSc), significant improvements in skin thickening were observed. Here, we report our analysis of sera collected during the clinical trial.

Methods.

We measured the levels of 46 cytokines, chemokines, and growth factors in the sera of individuals with dcSSc using Luminex and ELISA. Autoantigen microarrays were used to measure immunoglobulin G reactivity to 28 autoantigens. Elastic net regularization was used to identify a signature that was predictive of clinical improvement (reduction in the modified Rodnan skin score ≥ 5) during treatment with imatinib. The signature was also tested using sera from a clinical trial of nilotinib, a tyrosine kinase inhibitor that is structurally related to imatinib, in dcSSc.

Results.

The elastic net algorithm identified a signature, based on levels of CD40 ligand, chemokine (C-X-C motif) ligand 4 (CXCL4), and anti-PM/Scl-100, that was significantly higher in individuals who experienced clinical improvement than in those who did not (p = 0.0011). The signature was validated using samples from a clinical trial of nilotinib.

Conclusion.

Identification of patients with SSc with the greatest probability of benefit from treatment with imatinib has the potential to guide individualized treatment. Validation of the signature will require testing in randomized, placebo-controlled studies.Clinicaltrials.govNCT00555581andNCT01166139.
Utility of Dose Frequency Adjustment in Tocilizumab Administration for Rheumatoid Arthritis
Authors: Saito Shuntaro , Kaneko Yuko , Izumi Keisuke , Takeuchi Tsutomu
Published: March 2017

Objective.

To assess the utility of dose frequency adjustment of tocilizumab (TCZ) in rheumatoid arthritis (RA).

Methods.

Patients who received TCZ at 3-week (n = 24) or 5-week (n = 61) interval were evaluated.

Results.

Disease Activity Score at 28 joints based on erythrocyte sedimentation rate in the 3-week group significantly improved after 3 administrations at 3-week intervals (from 4.2 to 2.7, p = 0.001). Forty-five of the patients in the 5-week group (74%) successfully continued 5-week interval administration without disease exacerbation. Lower C-reactive protein level at TCZ initiation and shorter duration to remission achievement were key to successful dose frequency reduction.

Conclusion.

Adjusting the dose frequency of intravenous TCZ is a useful strategy.
Le genre : regards de psys
Authors: Blanc Élise
Published: March 2017

« Utiliser le genre comme outil d’analyse peut permettre au thérapeute de regarder le monde comme un Martien » : Élise Blanc nous invite à nous emparer d’un concept sociologique pour enrichir notre Parent culturel et ouvrir notre cadre de référence de psy sur la complexité de la construction d’une identité sexuée. Elle fait appel aux définitions de différents auteurs tels que Robert Stoller, Joan Wallach Scott, Vincent Bourseul. Elle aborde de manière historique le regard de la psychanalyse sur ce concept. Tout particulièrement, elle lève le voile sur un aspect méconnu de Freud souvent présenté comme misogyne. F.H.
Expatriation et identité : une analyse avec les systèmes des états du moi de José Grégoire
Authors: Ratynski Graciela
Published: March 2017

Rêver d’ailleurs, puis réaliser son rêve et partir vers un autre pays, quoi de plus magnifique ! Mais passés les premiers moments d’émerveillement, la désillusion est parfois au rendez-vous. Il y a souvent loin du rêve à la réalité. Même lorsqu’elle est désirée et volontaire, l’expatriation n’est jamais facile. Elle demande un effort d’adaptation, une grande capacité de changement et présente des difficultés que l’expatrié n’avait sans doute pas prévues. Graciela Ratynski, forte de sa propre expérience et de celle de son travail auprès de personnes en souffrance à la suite de leur installation en France, nous présente une analyse remarquable des changements d’identité rencontrés par les expatriés. Elle utilise pour cela la grille des systèmes d’états du moi de José Grégoire et nous montre comment chaque histoire d’expatriation est à la fois un deuil et une renaissance. F.B.
Caspar Brülows Autographe (1612-1627)
Authors: Andersen Peter
Published: March 2017

Les treize autographes de Caspar Brülow connus à ce jour datent tous de la période strasbourgeoise de sa vie. Ils dessinent un portrait parfois intime de cet auteur dramatique qui finit sa carrière comme professeur d’université et directeur de lycée : trois lettres aux scholarques, deux exlibris , une demande d’aide à son ami, le professeur d’histoire Matthias Bernegger, un avis sur une réforme de l’enseignement, un poème de remerciement à Bernegger, neuf semestres d’inscriptions d’élèves dans la matricule du lycée et trois lettres à un pasteur de Schaffhouse.
Brülows „Andromede“(1612) und Campeggis „Andromeda“ (1610)
Authors: Woesler Winfried
Published: March 2017

Le premier drame en latin Andromede de Caspar Brülow a été joué pour la première fois à l’Académie de Strasbourg en 1612. L’idée lui est venue problablement du livret de Ridolfo Campeggi pour l’opéra Andromeda de Girolamo Giacobbi de Bologne aujourd’hui perdu. La façon de traiter les mythes laisse penser à une influence. Un contact avec Bologne a existé grâce à son collègue Thomas-Christophorus Walliser qui a écrit d’après le modèle de l’opéra italien les chœurs pour le drame de Brülow.
Caspar Brülows Julius Caesar. I. Der Zuschaueraspekt
Authors: Roloff Hans-Gert
Published: March 2017

L’article reproduit le texte de la conférence donnée à Strasbourg, dans le cadre du Colloque Brülow qui coïncidait, à peu de temps près, avec les 400 ans de la première représentation du Jules César de Caspar Brülow dans cette même ville. La communication cherche à répondre à la question de savoir quel effet la représentation du plus célèbre régicide de l’histoire occidentale était censée produire sur les spectateurs du début du xvii e siècle, selon les intentions de l’auteur. Il n’y a pourtant pas d’éloge ou de condamnation directs du régicide dans la pièce. Le spectateur est amené à se faire lui-même une idée, au fur et à mesure que le drame se déroule. Par ce procédé neutre, Brülow lui fait ainsi peu à peu comprendre que le tyrannicide, malgré les justifications idéologiques avancées par les conjurés, n’est que le résultat de rivalités mesquines et d’imperfections morales, comme l’hypocrisie et l’envie face au grand homme qu’est Jules César pour Brülow. La conférence se borne à une analyse attentive du texte de la tragédie. D’autres aspects, notamment le choix et l’adaptation des sources et modèles littéraires ont en partie déjà été évoqués dans la critique et seront discutés en détail dans l’appareil critique qui accompagnera l’édition de Jules César préparée par l’auteur dans le cadre de la parution des œuvres complètes de Brülow.
Ein Epithalamium nach Georg Sabinus und ein Chronogramm Caspar Brülows Gedichte auf die Hochzeit Matthias Berneggers
Authors: Hanstein Michael
Published: March 2017

Pour le mariage de Matthias Bernegger, professeur au Gymnase et futur historien, Caspar Brülow a composé un chronogramme et un épithalame fait de 90 distiques élégiaques. Il s’appuie pour ce faire sur une élégie écrite par Georg Sabinus à l’occasion de ses fiançailles. Chez Sabinus comme chez Brülow, Vénus confie à Sabinus / Bernegger son fils Cupidon, qui devient leur élève. Ce dernier, afin de se venger de ses maîtres, les blesse de la flèche du sentiment amoureux qu’ils portent à leurs futures épouses. Brülow adapte cette élégie aux circonstances strasbourgeoises : il fait l’éloge de l’Académie et de ses maîtres, lui confère plus de grandeur en exhaussant le niveau des interventions des personnages et rivalise dans certains vers avec le style et la métrique de son modèle. Cet épithalame, le plus long des poèmes de circonstance que nous connaissions de Brülow constitue le témoignage le plus précoce de sa connaissance de Sabinus ainsi que de son étroite relation avec Bernegger.
Drei frühneuhochdeutsche Übersetzungen von Caspar Brülows Moses im Vergleich : Isaac Habrecht (1621), Christophorus Kerman (1621), Chunrad Merck (1641)
Authors: Lafond-Kettlitz Barbara
Published: March 2017

Le Moses de Caspar Brülow, représenté en néo-latin à Strasbourg lors de l’élévation de l’Académie au rang d’Université, a été – phénomène rare – transposé en nouveau haut allemand précoce par trois traducteurs différents. Les textes de Christopher Kermann et d’Isaac Habrecht ont été imprimés à Strasbourg encore avant la représentation les 16 et 17 août 1621, la version de Conradus Merckius a été jouée à Ulm en 1641 en langue vernaculaire. L’originalité de cette contribution consiste à présenter le texte de Christopher Kermann, considéré jusqu’à présent comme disparu. L’analyse comparée des trois traductions, notamment des paratextes, fait apparaître les points communs, tels que l’intention de vulgariser le Moses de Brülow auprès d’un large public, sa fonctionnalisation protestante et sa polémique anticatholique. Mais elle montre également les divergences, en particulier sur le plan esthétique: si les trois traducteurs restent fidèles à l’hypotexte de Brülow, Kermann opte pour la versification traditionnelle à l’Académie, tandis que Habrecht essaie de conférer à son texte une esthétique littéraire, et Merckius’ donnant la préférence à un texte non versifié, choisit ainsi le genre approprié à son public. Les trois traductions témoignent de l’effort des traducteurs pour réduire la distance entre culture savante et culture populaire.
Caspar Brülows heroisches Gedicht auf Martin Luther im Zusammenhang des Reformationsjubiläums von 1617
Authors: Schillinger Jean
Published: March 2017

Dans le cadre de la célébration à Strasbourg du centenaire de la Réforme (1617), Caspar Brülow prononça un « chant héroïque » en vers latins, glorifiant la personne de Luther. Ce discours fait une place centrale au Réformateur saxon, présenté sous des traits héroïques suggérant un caractère belliqueux parfaitement adapté aux conditions dans lesquelles fut organisé le centenaire de la Réforme. La singularité de l’action de Luther est soulignée par des références typologiques à des personnages de l’Ancien Testament comme Moïse, David, Samson ou Elie. Le discours de Brülow, prononcé dans une période de crise du luthéranisme allemand, possède une dimension polémique affirmée. Brülow s’oppose non seulement au catholicisme (et s’attaque aux jésuites de Molsheim), mais également aux calvinistes (pour des raisons théologiques et politiques). Le discours de Brülow est en marge de la célébration du centenaire de la Réforme : Brülow reprend les thèmes principaux du « jubilé », mais combine ceux-ci avec des préoccupations personnelles et professionnelles, qui concernent sa propre carrière et la défense de l’enseignement de la poésie à l’Académie de Strasbourg.
Cherche travailleur précaire, Bac+5 souhaité, 1800 € bruts mensuels
Authors: Pette Mathilde
Published: March 2017

Si les bénévoles restent majoritaires dans les associations de défense des étrangers, un processus de salarisation et de professionnalisation est à l’œuvre. Le Calaisis ne fait pas exception. Les salariés y travaillent dans l’urgence et dans des conditions difficiles, au contact de populations en grande précarité. Or cette précarité définit tout autant les contrats de travail des intervenants sociaux, les financements publics dont vivent les associations employeurs… voire les politiques migratoires pensées sur le court terme.
CAO : du vite fait au mal fait
Authors: Flaux Clémence
Published: March 2017

Dans les associations intervenant auprès des étrangers, les conditions de travail ne cessent de se dégrader au gré de politiques publiques toujours plus restrictives qui conduisent à un accueil au rabais. Avec le démantèlement de la jungle de Calais, l’État est allé encore plus loin pour disperser ses habitant·e·s, agissant en dehors de tout cadre légal, y compris auprès de mineurs dont la protection est pourtant strictement encadrée en France, et ce, avec la complicité d’opérateurs privés. Si la prise en charge des étrangers a souvent servi de banc d’essai à celle des publics précaires, le pire est à craindre.
Quel statut pour les enfants migrants ?
Authors: Eremenko Tatiana
Published: March 2017

Le regroupement familial ayant été réduit à la portion congrue ces dernières années du fait de politiques migratoires plus restrictives, les enfants d’étrangers arrivent en France par d’autres biais qui contribuent néanmoins à la précarisation de leur statut administratif et de leur séjour.
SOS Refoulement : une lutte oubliée
Authors: Peinado Alice D.
Published: March 2017

Le collectif SOS Refoulement est peu connu dans le paysage des luttes de l’immigration. Sans doute parce que son existence fut courte (4 ans) et circonstancielle, avec le durcissement de la politique migratoire sous la présidence de Valéry Giscard d’Estaing. Sans doute aussi parce que le collectif a péché par optimisme avec l’arrivée de la gauche au pouvoir. Pourtant, à lire ses archives, on se dit que les choses ont peu changé et que les raisons de cette lutte restent très actuelles.
LANDMARK STATEMENTS FROM THE AMERICAN HOSPITAL ASSOCIATION
Authors: Johnson Martha
Published: March 2017

PRACTICAL APPROACHES TO NURSING SERVICE ADMINISTRATION: PROGRAM OF CONTINUING EDUCATION FOR NURSING PERSONNEL
AN EVALUATION OF INDOOR ENVIRONMENTAL QUALITY AND OCCUPANT WELL-BEING IN MANITOBA SCHOOL BUILDINGS
Authors: Radwan Ahmed , Issa Mohamed H.
Published: March 2017

This exploratory research aims to evaluate indoor environmental quality in the classrooms of three school buildings in Southern Manitoba, Canada, and to evaluate the well-being of these schools' teachers as it pertains to their perception of their classrooms' indoor environment. The schools include a middle-aged, conventional school; a new, non-green school; and a new, green school certified using the Leadership in Energy and Environmental Design rating system. The methodology involved using a mobile instrument cart to conduct snapshot measurements of thermal comfort, indoor air quality, lighting and acoustics in classrooms and an occupant survey to evaluate teachers' long-term satisfaction with their classrooms' indoor environmental quality. The results showed that the new, green and new, non-green schools' classrooms performed better than the conventional, middle-aged school's classrooms with respect to some aspects of thermal comfort and indoor air quality only. Teachers in the new, green school and in the new, non-green school were more satisfied than teachers in the conventional, middle-aged school with their classrooms' overall indoor environmental quality, lighting quality and indoor air quality. Surprisingly, the new, green and new-non green school classrooms' performance were very comparable with the new, green school's classrooms performing statistically significantly better with respect to relative humidity. Similarly, none of the differences in teachers' satisfaction ratings between the new, green and new, non-green school were statistically significant.
An Intelligent Thermal Imaging System Adopting Fuzzy-Logic-Based Viola Jones Method in Flu Detection
Authors: Wong Wai Kit , Ishak Nur Izzati Nadiah Binti , Lim Heng Siong , Desa Jalil bin Md
Published: March 2017

Some infectious diseases can spread rapidly via a community of human or animals or both, either through airborne particles or viruses. Such rapid spread diseases may become a local, national or international widespread and contagious threat. As a symptom of infection, the body temperature of a disease carrier is higher than normal people. In this chapter, flu detection system using thermal imaging tool and computer vision techniques are discussed. An automatic flu detection method adopting human object extraction algorithm and fuzzy logic based Viola Jones algorithm are also discussed. The proposed system able to capture a thermogram of the human subject, detecting the eye region of the human subject, calculating the pixels values around the detected eye region, converted to temperature readings and further classified the subject's body temperature whether the subject satisfies a flu condition or not. Experimental results also shown that the proposed fuzzy logic based Viola Jones algorithm can trace out flu infectious personal from the input thermal images up to 80% of accuracy.
Thermal Imaging in Medical Science
Authors: Dey Nilanjan , Ashour Amira S. , Althoupety Afnan S.
Published: March 2017

Thermal imaging is a non-destructive, non-contact and rapid system. It reports temperature through measuring infrared radiation emanated by an object/ material surface. Automated thermal imaging system involves thermal camera equipped with infrared detectors, signal processing unit and image acquisition system supported by computer. It is elaborated in wide domains applications. Extensive focus is directed to the thermal imaging in the medical domain especially breast cancer detection. This chapter provided the main concept and the different applications of thermal imaging. It explores and analyses several works in the light of studding the thermograph. It is an effective screening tool for breast cancer prediction. Studies justify that thermography can be considered a complementary tool to detect breast diseases. The current chapter reviews many usages and limitations of thermography in biomedical field. Extensive recommendations for future directions are summarized to provide a structured vision of breast thermography.
Thermal Imaging in Smart Applications
Authors: Rehman Aqeel ur , Javid Tariq , Khan Iqbal Uddin , Murtaza Ahmar
Published: March 2017

Temperature measurement is an essential requirement for a large number of smart applications in medicine, agriculture, environment, and security domains, to name but a few. Conventionally, temperature measurements are mostly performed using thermometers, thermocouples, thermistors, and resistance temperature detectors. Most of these instruments require physical contact with the object to measure temperature at specific points. Infrared thermography has revolutionized the concept of temperature measurement. Infrared thermal imaging (IRTI) can provide the temperature mapping without a physical contact with the object of interest from a reasonable distance. A typical IRTI system comprises of a thermal camera equipped with infrared detector, a signal processing unit and an image acquisition system, usually in the form of an embedded system. Such cameras are utilized for applications like fault detection, irrigation management, motion detection, etc. This chapter briefly introduces use of thermal imaging in medicine, agriculture, environment, smart home/cities and security applications.
Personal Authentication through Finger Knuckle Geometric and Texture Feature Measurements
Authors: Kazhagamani Usha , Ezhilarasan M.
Published: March 2017

Finger Knuckle biometric is an emerging automated human identification approach that has received extensive significance in the area of research and real time applications in the recent past. Generally, a typical finger knuckle biometric system investigates the finger knuckle patterns present in the outer bend surface of the finger back region i.e., proximal phalanx region. In contrast, this paper focuses on the entire finger back region which includes proximal and distal phalanx of the finger knuckle surface for recognition. Further, this paper investigates a novel approach to achieve improved performance by simultaneous extraction and integration of finger knuckle geometric and texture features from a captured finger knuckle region. The geometric measures are derived by means of angular geometric analysis method which extracts angular-based feature information for unique identification. Similarly, texture measures are derived through statistical-based texture analysis methods.