bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Enantioselective Aldol Reactions with Masked Fluoroacetates.
Authors: Saadi Jakub , Wennemers Helma
Published: June 2016

The reaction of various aldehydes with the masked fluoroacetates (III) under either conditions A) (aromatic electron‐poor substrates) or B) leads to optically active fluorinated thioesters.
ChemInform Abstract: Intermolecular Noncovalent Hydroxy‐Directed Enantioselective Heck Desymmetrization of Cyclopentenol: Computationally Driven Synthesis of Highly Functionalized cis‐4‐Arylcyclopentenol Scaffolds.
Authors: de Oliveira Silva Juliana , Angnes Ricardo A. , Menezes da Silva Vitor H. , Servilha Bruno M. , Adeel Muhammad , Braga Ataualpa A. C. , Aponick Aaron , Correia Carlos Roque D.
Published: June 2016

The Heck—Matsuda desymmetrization of 3‐cyclopenten‐1‐ol is studied by both computational and synthetic means.
ChemInform Abstract: Catalyst‐Controlled Regiodivergent Vinylogous aza‐Morita—Baylis—Hillman Reactions.
Authors: Hyakutake Ryuichi , Gondo Naruhiro , Ueda Yoshihiro , Yoshimura Tomoyuki , Furuta Takumi , Kawabata Takeo
Published: June 2016

Regiodivergent vinylogous aza‐MBH reaction is developed.
ChemInform Abstract: N‐Tosyl‐1,5,2,6‐dithiadiazocane: A Waste‐Free Electrophilic Sulfur Reagent for the Efficient Synthesis of Medium‐Ring S,N‐Heterocycles.
Authors: Javorskis Tomas , Bagdziunas Gintautas , Orentas Edvinas
Published: June 2016

Title compound (II) is introduced as a new, convenient and highly reactive electrophilic sulfur/nucleophilic nitrogen synthon for simple preparation of medium‐sized S,N‐heterocycles.
ChemInform Abstract: Factors that Control C—C Cleavage versus C—H Bond Hydroxylation in Copper‐Catalyzed Oxidations of Ketones with O2.
Authors: Tsang Althea S.‐K. , Kapat Ajoy , Schoenebeck Franziska
Published: June 2016

A detailed experimental and computational study on the title reaction is presented.
ChemInform Abstract: One‐Pot Hydrothermal Synthesis of H3PW12O40 Supported on Zeolite Imidazolate Frameworks (ZIF‐8): A Highly Efficient Heterogeneous Catalyst for Oxidation of Sulfides to Sulfoxides and Sulfones.
Authors: Ebrahimi Negar , Fazaeli Razieh , Aliyan Hamid
Published: June 2016

The title catalyst system is prepared and used for the oxidation of sulfides (I) to sulfoxides or sulfones, resp., utilizing hydrogen peroxide under heterogeneous conditions.
ChemInform Abstract: Improved Second Generation Iron Pincer Complexes for Effective Ester Hydrogenation.
Authors: Elangovan Saravanakumar , Wendt Bianca , Topf Christoph , Bachmann Stephan , Scalone Michelangelo , Spannenberg Anke , Jiao Haijun , Baumann Wolfgang , Junge Kathrin , Beller Matthias
Published: June 2016

A recently published protocol for hydrogenation of esters to alcohols is improved by using a sterically less hindered iron pincer complex, that shows superior catalytic activity.
ChemInform Abstract: Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of 1,2‐Dicarbonyl Compounds.
Authors: Ren Xiaoyu , Du Haifeng
Published: June 2016

A variety of optically active α‐hydroxy ketones and esters is prepared utilizing the combination of tricyclohexylphosphine and chiral alkenylborane generated in situ from diyne as frustrated Lewis pair catalyst.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Monoacylation of Vicinal Diols.
Authors: Kuwano Satoru , Masuda Toshinobu
Published: June 2016

Vicinal cis‐diols give similar yields.
ChemInform Abstract: Cross‐Metathesis of Broensted Acid Masked Alkenylamines with Acrylates for the Synthesis of Polyamide Monomers.
Authors: Spiccia Nicolas Daniel , Solyom Szabolcs , Woodward Clint Peter , Jackson William Roy , Robinson Andrea Jane
Published: June 2016

Cross‐metathesis of alkenylamine salts with an excess of methyl acrylate or acrylic acid provides commercially valuable polyamide monomers.
ChemInform Abstract: Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies.
Authors: Pieber Bartholomaeus , Kappe C. Oliver
Published: June 2016

The simple and convenient protocol is based on the transformation of 2,2,2‐trifluoroethaneamine and sodium nitrite to form trifluoromethyl diazomethane.
ChemInform Abstract: N‐Bromosuccinimide‐Mediated Thiocyanation of Cyclohexene‐Fused Isoxazoline N‐Oxides.
Authors: Ichake Sachin S. , Rajawinslin R. R. , Kavala Veerababurao , Villuri Bharath Kumar , Yang Huei‐Ting , Kuo Chun‐Wei , Yao Ching‐Fa
Published: June 2016

A NBS‐promoted oxidative ring‐opening of isoxazolines of type (I) and (V) with thiocyanate gives SCN‐containing cyclohexenone oximes.
ChemInform Abstract: Broad Scope Aminocyclization of Enynes with Cationic JohnPhos—Gold(I) Complex as the Catalyst.
Authors: Miller Ricarda , Carreras Javier , Muratore Michael E. , Gaydou Morgane , Camponovo Francesco , Echavarren Antonio M.
Published: June 2016

The novel aminocyclization of 1,6‐enynes works well with a wide variety of primary or secondary amines using a robust cationic gold(I) complex.
ChemInform Abstract: Asymmetric Lewis Acid Organocatalysis of the Diels—Alder Reaction by a Silylated C—H Acid.
Authors: Gatzenmeier Tim , van Gemmeren Manuel , Xie Youwei , Hoefler Denis , Leutzsch Markus , List Benjamin
Published: June 2016

Enantioselective Diels—Alder reactions of cinnamates with cyclopentadiene catalyzed by in situ generated silylium‐carbanion pairs as extremely active Lewis acid are investigated.
ChemInform Abstract: Selective Double Carbomagnesiation of Internal Alkynes Catalyzed by Iron‐N‐Heterocyclic Carbene Complexes: A Convenient Method to Highly Substituted 1,3‐Dienyl Magnesium Reagents.
Authors: Liu Yuesheng , Wang Lijun , Deng Liang
Published: June 2016

An iron(II)‐N‐heterocyclic carbene (NHC) complex is found to be effective as precatalyst for double carbometalation of unsymmetrical internal alkynes with Grignard‐reagents.
ChemInform Abstract: Electrochemical Amination of Less‐Activated Alkylated Arenes Using Boron‐Doped Diamond Anodes.
Authors: Herold Sebastian , Moehle Sabine , Zirbes Michael , Richter Frank , Nefzger Hartmut , Waldvogel Siegfried R.
Published: June 2016

A previously published protocol for anodic C—amination of electron‐rich arenes is extended towards utilization of less‐activated benzenes.
ChemInform Abstract: N‐Arylation of Tertiary Amines under Mild Conditions.
Authors: Hirsch Maayan , Dhara Shubhendu , Diesendruck Charles E.
Published: June 2016

Trialkylaryl, dialkyldiaryl, and novel triarylalkyl ammonium salts are prepared under transition‐metal‐free conditions.
ChemInform Abstract: Bargellini Condensation of Ninhydrin as a Ketone and Substituted Anilines as Nucleophiles.
Authors: Rashid Zahra , Ghahremanzadeh Ramin , Naeimi Hossein
Published: June 2016

Novel α‐amino acids based on ninhydrin are conveniently synthesized by NaOH‐promoted Bargellini reaction of various substituted anilines as nucleophiles with ninhydrin and chloroform under mild reaction conditions in high to excellent yields and with high purity.
ChemInform Abstract: Direct Catalytic Asymmetric Mannich‐Type Reaction of α,β‐Unsaturated γ‐Butyrolactam with Ketimines.
Authors: Lin Shaoquan , Kumagai Naoya , Shibasaki Masakatsu
Published: June 2016

The presence of a thiophosphinoyl group on the nitrogen of the starting ketimines is crucial for both electrophilic activation and α‐addition of γ‐butyrolactams.
ChemInform Abstract: Cu(I) Catalyzed Synthesis of Anhydrides from Aldehydes via CDC‐Pathway at Ambient Temperature.
Authors: Nuree Yasin , Singha Raju , Ghosh Munmun , Roy Pronay , Ray Jayanta K.
Published: June 2016

An easy and efficient methodology for the synthesis of anhydrides starting from commercially available aromatic aldehydes using low‐cost Cu(I) catalyst and TBHP as oxidant at room temperature with satisfactory yields is reported.
ChemInform Abstract: Visible‐Light‐Mediated Synthesis of Amides from Aldehydes and Amines via in situ Acid Chloride Formation.
Authors: Iqbal Naeem , Cho Eun Jin
Published: June 2016

A one‐pot photocatalysis‐based amide synthesis starting from aromatic aldehydes is described.
ChemInform Abstract: Graphene Oxide: A Promising Carbocatalyst for the Regioselective Thiocyanation of Aromatic Amines, Phenols, Anisols and Enolizable Ketones by Hydrogen Peroxide/KSCN in Water.
Authors: Khalili Darisush
Published: June 2016

The direct thiocyanation of a variety of arenes and carbonyl compounds possessing an α‐hydrogen is accomplished by reaction with KSCN in the presence of hydrogen peroxide using graphene oxide as catalyst.
ChemInform Abstract: SnBr4‐Promoted Friedel—Crafts Type Dehydrative Alkylation Reaction of Diarylmethanols with 2‐Naphthol Derivatives.
Authors: Suzuki Nobuharu , Tsuchihashi Shiori , Nakata Kenya
Published: June 2016

An efficient Friedel—Crafts type dehydrative alkylation reaction of diarylmethanols with 2‐naphthols promoted by SnBr4 under mild conditions is developed.
ChemInform Abstract: Fused Catechol Ethers from Gold(I)‐Catalyzed Intramolecular Reaction of Propargyl Ethers with Acetals.
Authors: Pati Kamalkishore , dos Passos Gomes Gabriel , Harris Trevor , Alabugin Igor V.
Published: June 2016

The title reaction proceeds under mild conditions following an alkyne activation/nucleophilic addition/alkoxyl group migration/cyclization/aromatization mechanism.
ChemInform Abstract: Modular Approach to 9‐Monosubstituted Fluorene Derivatives Using MoV Reagents.
Authors: Franzmann Peter , Trosien Simon , Schubert Moritz , Waldvogel Siegfried R.
Published: June 2016

The MoV‐mediated oxidative intramolecular coupling of functionalized diphenylpropanone derivatives (VII) and (IX) leads to desired 9‐substituted fluorenes (VIII) and (X), resp., in moderate yields.
ChemInform Abstract: Studies of the Mechanism and Origins of Enantioselectivity for the Chiral Phosphoric Acid‐Catalyzed Stereoselective Spiroketalization Reactions.
Authors: Khomutnyk Yaroslav Ya. , Argueelles Alonso J. , Winschel Grace A. , Sun Zhankui , Zimmerman Paul M. , Nagorny Pavel
Published: June 2016

Hammett analysis of the reaction kinetics reveals positive charge accumulation in the transition state.
ChemInform Abstract: A Convenient and Rapid Microwave‐Assisted Synthesis of Spirooxindoles in Aqueous Medium and Their Antimicrobial Activities.
Authors: Mali Prakash R. , Chandrasekhara Rao L. , Bangade Vikas M. , Shirsat Prashishkumar K. , George Sara A. , Jagadeesh Babu N. , Meshram H. M.
Published: June 2016

Functionalized spirooxindole derivatives are simply and eco‐friendly synthesized by an one‐pot, three‐component aqueous phase protocol under microwave irradiation with good diastereoselectivity.
ChemInform Abstract: Synthesis of Bicyclic γ‐Butyrolactone Derivatives by Rhodium Catalyzed Intramolecular C—H Insertion of α‐Diazo α‐Phosphoryl Cycloalkyl Esters.
Authors: Shie Jr‐Yun , Zhu Jia‐Liang
Published: June 2016

Four title esters bearing different cycloalkyl substituents (cyclopentyl‐cyclooctyl) are investigated as suitable substrates in the formation of the desired bicyclic oxygen heterocycles.
ChemInform Abstract: CuBr2 Catalyzed Synthesis of 3‐Furylphthalides.
Authors: Shcherbinin Vitaly A. , Shpuntov Pavel M. , Konshin Valery V. , Butin Alexander V.
Published: June 2016

A straightforward and efficient CuBr2/AcOH catalyzed synthesis of the title compounds from readily available phthalaldehydic acids and furans is developed.
ChemInform Abstract: Copper(II)/Silver(I)‐Catalyzed Sequential Alkynylation and Annulation of Aliphatic Amides with Alkynyl Carboxylic Acids: Efficient Synthesis of Pyrrolidones.
Authors: Zhang Jitan , Li Danyang , Chen Hui , Wang Binjie , Liu Zhanxiang , Zhang Yuhong
Published: June 2016

This copper‐catalyzed tandem decarboxylative cross‐coupling/cyclization provides a highly efficient method for preparation of pyrrolidones.
ChemInform Abstract: Stereoselective Synthesis of Functionalized Pyrrolidines by the Diverted N—H Insertion Reaction of Metallocarbenes with β‐Aminoketone Derivatives.
Authors: Nicolle Simon M. , Lewis William , Hayes Christopher J. , Moody Christopher J.
Published: June 2016

Various catalysts are found to promote the diverted N—H insertion of diazocarbonyl compounds with β‐aminoketones to afford highly substituted proline derivatives with good diastereoselectivities.
ChemInform Abstract: Acylation of Indoles via Photoredox Catalysis: A Route to 3‐Acylindoles.
Authors: Gu Lijun , Jin Cheng , Liu Jiyan , Zhang Hongtao , Yuan Minglong , Li Ganpeng
Published: June 2016

The title compounds are efficiently prepared from simple indoles and α‐oxo acids via Ir/Ni‐cocatalyzed, visible light induced C—C and C—H bond activation.
ChemInform Abstract: Bifunctional Tertiary Amine‐Squaramide Catalyzed Asymmetric Catalytic 1,6‐Conjugate Addition/Aromatization of para‐Quinone Methides with Oxindoles.
Authors: Deng Yu‐Hua , Zhang Xiang‐Zhi , Yu Ke‐Yin , Yan Xu , Du Ji‐Yuan , Huang Hanmin , Fan Chun‐An
Published: June 2016

The novel highly diastereoselective and enantioselective approach affords a wide range of diarylmethine‐substituted oxindoles bearing vicinal tertiary and quaternary stereocenters.
ChemInform Abstract: Visible‐Light‐Mediated Photocatalytic Difunctionalization of Olefins by Radical Acylarylation and Tandem Acylation/Semipinacol Rearrangement.
Authors: Bergonzini Giulia , Cassani Carlo , Lorimer‐Olsson Haldor , Hoerberg Johanna , Wallentin Carl‐Johan
Published: June 2016

A novel method for the mild photoredox‐mediated tandem radical acylarylation and tandem acylation/semipinacol rearrangement is developed.
ChemInform Abstract: Synthesis of Chiral α‐Trifluoromethylamines with 2,2,2‐Trifluoroethylamine as a “Building Block”.
Authors: Yan Wenjin , et al.
Published: June 2016

The title amines are efficiently prepared by asymmetric SN2′‐SN2′ reaction between trifluoroethylisatin ketimines and MBH type carbonates using β‐isocupreidine, a cinchonine derived alkaloid, as catalyst.
ChemInform Abstract: Functionalization of Silyldienol Ethers at the γ‐Position via 2‐Silyloxypentadienyl Cations.
Authors: Ayala Caitlan E. , Dange Nitin S. , Stepherson Jacob R. , Henry Jeffrey L. , Fronczek Frank R. , Kartika Rendy
Published: June 2016

A method for the preparation of silyldienol ethers bearing a tetrasubstituted double bond with controllable stereoconfiguration is elaborated.
ChemInform Abstract: Ruthenium‐Catalyzed, Site‐Selective C—H Allylation of Indoles with Allyl Alcohols as Coupling Partners.
Authors: Kumar Gangam Srikanth , Kapur Manmohan
Published: June 2016

The site‐selectivity of the mono‐selective method is based on the use of an N‐pyridyl directing group which may be cleaved off without or with significant isomerization of the products′ allyl group.
ChemInform Abstract: C—H Activation‐Based Traceless Synthesis via Electrophilic Removal of a Directing Group. Rhodium(III)‐Catalyzed Entry into Indoles from N‐Nitroso and α‐Diazo‐β‐keto Compounds.
Authors: Wang Jie , Wang Mingyang , Chen Kehao , Zha Shanke , Song Chao , Zhu Jin
Published: June 2016

41 examples
ChemInform Abstract: Asymmetric Copper‐Catalyzed C—N Cross‐Couplings Induced by Visible Light.
Authors: Kainz Quirin M. , Matier Carson D. , Bartoszewicz Agnieszka , Zultanski Susan L. , Peters Jonas C. , Fu Gregory C.
Published: June 2016

Fully substituted stereocenters are highly enantioselectively generated by photoinduced copper‐catalyzed coupling of readily available racemic tertiary alkyl chloride electrophiles with various amines.
ChemInform Abstract: Cyclative Cascades of Allenamides Derived from Amino Acids: Synthesis of Annulated Indoxyl Derivatives.
Authors: Petkovic Milos , Nasufovic Veselin , Djukanovic Dimitrije , Vujosevic Zorana Tokic , Jadranin Milka , Matovic Radomir , Savic Vladimir
Published: June 2016

The title compounds are envisioned to be useful building blocks for syntheses of natural products and their analogs.
ChemInform Abstract: Copper(II)‐Catalyzed Synthesis of Indoloquinoxalin‐6‐ones Through Oxidative Mannich Reaction.
Authors: Gogoi Anupal , Sau Prasenjit , Ali Wajid , Guin Srimanta , Patel Bhisma K.
Published: June 2016

A Cu‐catalyzed synthesis of indoloquinoxalin‐6‐ones is developed, starting from o‐indolyl‐N,N‐dialkylamines through sp3 C—H bond oxidation in the α‐position to the nitrogen atom with di‐tert‐butyl peroxide as oxidant.
ChemInform Abstract: Asymmetric Broensted Base Catalyzed and Directed [3 + 2] Cycloaddition of 2‐Acyl Cycloheptatrienes with Azomethine Ylides.
Authors: Lauridsen Vibeke H. , Ibsen Lise , Blom Jakob , Joergensen Karl Anker
Published: June 2016

The organocatalytic reaction of 2‐acyl cycloheptatrienes with azomethine ylides proceeds by a [3+2] cycloaddition which is in contrast to the corresponding Lewis acid‐catalyzed reaction, in which a [3+6] cycloaddition takes place.
ChemInform Abstract: Palladium‐Catalyzed Regioselective C‐2 Arylation of 7‐Azaindoles, Indoles, and Pyrroles with Arenes.
Authors: Laha Joydev K. , Bhimpuria Rohan A. , Prajapati Dilip V. , Dayal Neetu , Sharma Shubhra
Published: June 2016

A high acid concentration in the reaction medium is essential to obtain complete C‐2 regioselectivity in the arylation of N‐protected 7‐azaindoles and indoles Low acidity of the reaction medium is required to achieve 2‐mono‐arylation in pyrroles.
ChemInform Abstract: A Re‐Engineering Approach: Synthesis of Pyrazolo[1,2‐a]pyrazoles and Pyrano[2,3‐c]pyrazoles via an Isocyanide‐Based Four‐Component Reaction under Solvent‐Free Conditions.
Authors: Shaabani Ahmad , Sepahvand Heshmatollah , Keramati Nejad Mina
Published: June 2016

Title compounds are synthesized in high yields by a novel interesting four‐component reaction of dialkyl acetylenedicarboxylates, isocyanides, and ethyl acetoacetate with hydrazine hydrate or phenylhydrazine under neat conditions.
ChemInform Abstract: Access to Imidazole Derivatives by Silver(I) Carbonate Mediated Coupling of Vinyl Azides with Secondary Amines.
Authors: Adiyala Praveen Reddy , Borra Satheesh , Kamal Ahmed , Maurya Ram Awatar
Published: June 2016

An operationally simple protocol for preparation of a set of imidazole derivatives via formation of three new C—N bonds in a cascade process is developed.
ChemInform Abstract: A Green and Convenient Approach Toward Benzimidazole Derivatives and Their Antimicrobial Activity.
Authors: Wen Jing , Luo Yun‐Lei , Zhang Hui‐Zhen , Zhao Huan‐Huan , Zhou Cheng‐He , Cai Gui‐Xin
Published: June 2016

The title derivatives are synthesized by aza‐Michael addition of benzimidazoles to α,β‐unsaturated compounds in water with palladium acetate as catalyst.
ChemInform Abstract: Copper‐Mediated [3 + 2] Annulation of 3‐N‐Hydroxyallylamines with Nitrosoarenes.
Authors: Ghorpade Satish , Jadhav Prakash D. , Liu Rai‐Shung
Published: June 2016

The title reaction is investigated for a series of substrates to produce 4,5‐disubstituted isoxazolidine structures as single diastereomers (mechanism).
ChemInform Abstract: Facile Synthesis of 1,3‐Tiazolidin‐4‐ones as Antitubercular Agents.
Authors: Subhedar Dnyaneshwar D. , Shaikh Mubarak H. , Arkile Manisha A. , Yeware Amar , Sarkar Dhiman , Shingate Bapurao B.
Published: June 2016

21 Title compounds are prepared and tested for their antitubercular activities.
ChemInform Abstract: Copper(I)‐Catalyzed Cascade Reaction of 2‐Haloaryl Isothiocyanates with Isocyanides: A Strategy to Construct Benzo[d]imidazo[5,1‐b]thiazoles.
Authors: Hao Wenyan , Sang Xiaoyan , Jiang Jing , Cai Mingzhong
Published: June 2016

The novel copper‐catalyzed tandem [3 + 2] cycloaddition and C—S coupling of 2‐haloaryl isothiocyanates and isocyanoacetates affords the title benzo[d]imidazo[5,1‐b]thiazoles in high yields.
ChemInform Abstract: Design, Synthesis, and Analysis of Antagonists of GPR55: Piperidine‐Substituted 1,3,4‐Oxadiazol‐2‐ones.
Authors: Abood Mary E. , et al.
Published: June 2016

A series of oxadiazole derivatives is prepared and tested for activity as antagonists at GPR55 in cellular beta‐arrestin redistribution assays.
ChemInform Abstract: New Tandem Reductive Rearrangement of 3‐Furylphthalides into 3‐(3‐Oxoalkyl)isocoumarins.
Authors: Shpuntov Pavel M. , Shcherbinin Vitaly A. , Abaev Vladimir T. , Butin Alexander V.
Published: June 2016

A high‐yielding tandem procedure for the one‐pot conversion of 3‐(2‐furyl)phthalides into functionalized isocoumarins mediated by readily available reagents is developed.
ChemInform Abstract: 2‐Bromo‐6‐isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry.
Authors: van der Heijden Gydo , Jong J. A. W. , Ruijter Eelco , Orru Romano V. A.
Published: June 2016

The title pyridine is utilized in Ugi type and Passerini type reactions leading to various carboxylic amides.
ChemInform Abstract: Copper‐Catalyzed Annulation: A Method for the Systematic Synthesis of Phenanthridinium Bromide.
Authors: Jhang Yuan‐Ye , Fan‐Chiang Tai‐Ting , Huang Jun‐Min , Hsieh Jen‐Chieh
Published: June 2016

A series of phenanthridinium bromides (III) and (IX) is readily obtained by a novel copper‐catalyzed annulation of bromo aldehydes with amines.
ChemInform Abstract: Site‐Selective Intermolecular Oxidative C‐3 Alkenylation of 7‐Azaindoles at Room Temperature.
Authors: Kannaboina Prakash , Kumar K. Anil , Das Parthasarathi
Published: June 2016

The title reaction is catalyzed by Pd(OAc)2 and uses Cu(OTf)2 as an oxidative cocatalyst and molecular oxygen as the terminal oxidant.
ChemInform Abstract: Redox‐Annulation of Cyclic Amines and β‐Ketoaldehydes.
Authors: Chen Weijie , Seidel Daniel
Published: June 2016

The intramolecular redox‐Mannich reaction between 1,2,3,4‐tetrahydroisoquinoline or tryptoline and β‐ketoaldehydes provides a facile access to benzo[a]quinolizine‐2‐ones.
ChemInform Abstract: Synthesis of Alkaloid‐Mimicking Tricyclic Skeletons by Diastereo‐ and Regioselective Ugi/Ipso‐Cyclization/Aza‐Michael Cascade Reaction in One‐Pot.
Authors: Yugandhar D. , Kuriakose Sunu , Nanubolu Jagadeesh Babu , Srivastava Ajay Kumar
Published: June 2016

The scalable, operationally simple method generates complex functionalized azaspirofused tricyclic scaffolds with three stereogenic centers one of which is quaternary.
ChemInform Abstract: Rhodium‐Catalyzed/Copper‐Mediated Tandem C(sp2)—H Alkynylation and Annulation: Synthesis of 11‐Acylated Imidazo[1,2‐a:3,4‐a′]dipyridin‐5‐ium‐4‐olates from 2H‐[1,2′‐Bipyridin]‐2‐ones and Propargyl Alcohols.
Authors: Li Ting , Wang Zhiqiang , Xu Kun , Liu Wenmin , Zhang Xu , Mao Wutao , Guo Yongming , Ge Xiaolin , Pan Fei
Published: June 2016

The scalable title reaction tolerates variously functionalized 2H‐[1,2′‐bipyridin]‐2‐ones as well as aryl and hetaryl substituted propargyl alcohols, but no alkyl substituted derivatives of the latter.
ChemInform Abstract: CsOH/γ‐Al2O3: A Heterogeneous Reusable Basic Catalyst for One‐Pot Synthesis of 2‐Amino‐4,6‐diaryl Pyrimidines.
Authors: Nimkar Amey , Ramana M. M. V. , Betkar Rahul , Ranade Prasanna , Mundhe Balaji
Published: June 2016

The title pyrimidines are simply and efficiently synthesized by a green one‐pot three‐component reaction of acetophenone, various aromatic aldehydes, and guanidine hydrochloride using CsOH/γ‐Al2O3 as catalyst.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Dihydrobenzoxazinones Bearing Trifluoromethylated Quaternary Stereocenters.
Authors: Lou Hengqiao , Wang Yongtao , Jin Enze , Lin Xufeng
Published: June 2016

A chiral phosphoric acid‐catalyzed enantioselective aza‐Friedel—Crafts reaction of trifluoromethyl benzoxazinones with pyrroles is given.
ChemInform Abstract: Formal Ir‐Catalyzed Ligand‐Enabled ortho and meta Borylation of Aromatic Aldehydes via in situ‐Generated Imines.
Authors: Bisht Ranjana , Chattopadhyay Buddhadeb
Published: June 2016

Two complementary methods for ortho‐ and meta‐selective C—H bond activation/borylation of aromatic aldehydes are developed.
ChemInform Abstract: Cobalt‐Catalyzed Benzylic Borylation: Enabling Polyborylation and Functionalization of Remote, Unactivated C(sp3)—H Bonds.
Authors: Palmer W. Neil , Obligacion Jennifer V. , Pappas Iraklis , Chirik Paul J.
Published: June 2016

Rare examples for diborylation of benzylic and homobenzylic C—H bonds and an unprecedented triborylation of the toluene methyl group are presented.
ChemInform Abstract: Metal‐Free Diimide Reduction of Alkenylphosphonates: Simple and Efficient Protocol for the Synthesis of α‐Substituted Ethylphosphonates.
Authors: Fang Yewen , Yuan Meijuan , Jin Xiaoping , Zhang Li , Li Ruifeng , Yang Shaoshuai , Fang Mei
Published: June 2016

An efficient and simple method for the synthesis of α‐substituted ethylphosphonates via diimide reduction of α‐substituted vinylphosphonates is reported.
ChemInform Abstract: Oxidative C(sp2)—H Phosphonation of Aldehyde Hydrazones.
Authors: Xu Pan , Wu Zhongkai , Zhou Nengneng , Zhu Chengjian
Published: June 2016

The practical procedure is successfully applied to the reaction between various aldehyde hydrazones and diphenylphosphine oxide or ethyl phenylphosphinate, but fails using diethyl or diphenyl phosphonate.
ChemInform Abstract: Highly Regio‐ and Stereoselective Intermolecular Seleno‐ and Thioamination of Alkynes.
Authors: Zheng Guangfan , Zhao Jinbo , Li Zhanyu , Zhang Qiao , Sun Jiaqiong , Sun Haizhu , Zhang Qian
Published: June 2016

The N‐fluorobenzenesulfonimide acts both as the oxidant and the amination reagent in the intermolecular chalcogenative amination of alkynes, which grants facile, highly regio‐ and stereoselective access to chalcogenated enamides.
ChemInform Abstract: De novo Design of Protein Homo‐Oligomers with Modular Hydrogen‐Bond Network‐Mediated Specificity.
Authors: Baker David , et al.
Published: June 2016

In nature, structural specificity in DNA and proteins is encoded differently: In DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar interactions.
ChemInform Abstract: Synthesis and Absolute Configuration of Acanthodendrilline, a New Cytotoxic Bromotyrosine Alkaloid from the Thai Marine Sponge Acanthodendrilla sp.
Authors: Sirimangkalakitti Nachanun , Yokoya Masashi , Chamni Supakarn , Chanvorachote Pithi , Plubrukrn Anuchit , Saito Naoki , Suwanborirux Khanit
Published: June 2016

Acanthodendrilline (S)‐I is isolated and shown to exhibit a threefold more potent cytotoxicity against human non‐small cell lung cancer H292 cell line than (R)‐(I).
ChemInform Abstract: Defects in Nanodiamonds: Application of High‐Frequency CW and Pulse EPR, ODMR
Authors: Yavkin B. V. , Soltamov V. A. , Babunts R. A. , Anisimov A. N. , Baranov P. G. , Shakhov F. M. , Kidalov S. V. , Vul' A. Ya. , Mamin G. V. , Orlinskii S. B.
Published: June 2016

Review: 45 refs.
ChemInform Abstract: Functional Metal‐organic Molecules and Materials Derived from Rigid and Flexible P‐N Scaffolds
Authors: Boomishankar Ramamoorthy , Srivastava Anant Kumar
Published: June 2016

Review: 27 refs.
ChemInform Abstract: Gold‐Catalyzed Domino Reactions
Authors: Michelet Veronique
Published: June 2016

Review: [hydration, hydroxylation, and hydroamination as key reations for various cascae transformations, also in total synthesis]
ChemInform Abstract: Hypervalent Sulfur Fluorides and the Design of Liquid Crystals
Authors: Kirsch Peer , Bremer Matthias
Published: June 2016

Review: 56 refs.
ChemInform Abstract: N‐Arylation of Amidines and Guanidines: An Update
Authors: Kantin Grigory , Krasavin Mikhail
Published: June 2016

Review: introduction of an (het)aryl group at a nitrogen atom as a key step to construt biologically active compounds
ChemInform Abstract: Advances in Exploring Alternative Taxol Sources
Authors: Liu W. C. , Gong T. , Zhu P.
Published: June 2016

Review: 75 refs.
ChemInform Abstract: A New Catalytic System for Ru‐Catalyzed C—H Arylation Reactions and Its Application in the Practical Syntheses of Pharmaceutical Agents
Authors: Seki Masahiko
Published: June 2016

Review: [29 refs.
ChemInform Abstract: Total Syntheses of Echinopines A and B, Sesquiterpenes with a Unique Tetracyclic [3‐5‐5‐7] Skeleton
Authors: Sanogo Youssouf , Allievi Luca , Lecourt Camille , Dhambri Sabrina , Ardisson Janick , Sorin Geoffroy , Lannou Marie‐Isabelle
Published: June 2016

Review: 30 refs.
ChemInform Abstract: Self‐Assembly of Cyclic Peptides and Peptidomimetic Macrocycles: Linking Structure with Function
Authors: Ghorai Abhijit , Achari Basudeb , Chattopadhyay Partha
Published: June 2016

Review: 108 refs.
ChemInform Abstract: Synthesis Routes to anti‐HIV Drugs
Authors: Mandala Devender , Thompson Warren A. , Watts Paul
Published: June 2016

Review: 84 refs.
ChemInform Abstract: The Impact of Asymmetric Organocatalysis in Dearomatization and Aromatization of Carbocycles: Increasing Molecular Complexity and Diversity
Authors: Pantaine Loic , Moreau Xavier , Coeffard Vincent , Greck Christine
Published: June 2016

Review: [39 refs.
ChemInform Abstract: Metal‐Catalyzed Synthesis of Isocoumarin Derivatives (Microreview)
Authors: Ashraf Zaman
Published: June 2016

Review: 32 refs.
ChemInform Abstract: Synthesis of [1,2,4]Triazolo[1,5‐a]pyrimidine (Microreview)
Authors: Fizer Maksym , Slivka Mikhailo
Published: June 2016

Review: [23 refs.
ChemInform Abstract: Dimethyl Sulfoxide as a Synthon in Organic Chemistry
Authors: Jones‐Mensah Ebenezer , Karki Megha , Magolan Jakob
Published: June 2016

Review: [84 refs.
ChemInform Abstract: Diversity‐Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology
Authors: Collins Suil , Bartlett Sean , Nie Feilin , Sore Hannah F. , Spring David R.
Published: June 2016

Review: [109 refs.
ChemInform Abstract: Synthetic Applications of Pseudocyclic Hypervalent Iodine Compounds
Authors: Yoshimura Akira , Yusubov Mekhman S. , Zhdankin Viktor V.
Published: June 2016

Review: 99 refs.
ChemInform Abstract: Advances in Chemistry and Bioactivity of the Genus Chisocheton Blume
Authors: Shilpi Jamil A. , Saha Sanjib , Chong Soon‐Lim , Nahar Lutfun , Sarker Satyajit D. , Awang Khalijah
Published: June 2016

Review: 75 refs.
ChemInform Abstract: Production of C(sp3)—Csp(3) Bonds Through Palladium‐Catalyzed Tsuji—Trost‐Type Reactions of (Hetero)Benzylic Substrates
Authors: Le Bras Jean , Muzart Jacques
Published: June 2016

Review: [63 refs.
ChemInform Abstract: Combining Solid‐State NMR Spectroscopy with First‐Principles Calculations — A Guide to NMR Crystallography
Authors: Ashbrook Sharon E. , McKay David
Published: June 2016

Review: 144 refs.
ChemInform Abstract: H‐Bonding Directed Programmed Supramolecular Assembly of Naphthalene‐Diimide (NDI) Derivatives
Authors: Das Anindita , Ghosh Suhrit
Published: June 2016

Review: 113 refs.
ChemInform Abstract: Integrating Metabolic Engineering and Heterogeneous Chemocatalysis: New Opportunities for Biomass to Chemicals
Authors: Huo Yanping , Zeng Huaqiang , Zhang Yugen
Published: June 2016

Review: [17 refs.
ChemInform Abstract: Can Computed Crystal Energy Landscapes Help Understand Pharmaceutical Solids?
Authors: Price Sarah L. , Braun Doris E. , Reutzel‐Edens Susan M.
Published: June 2016

Review: It is shown that the crystal energy landscape gives a useful framework for understanding the complexity of solid form landscapes for small drug molecules, and has the potential to help direct effective experimentation.
ChemInform Abstract: Harvest and Utilization of Chemical Energy in Wastes by Microbial Fuel Cells
Authors: Sun Min , Zhai Lin‐Feng , Li Wen‐Wei , Yu Han‐Qing
Published: June 2016

Review: 229 refs.
ChemInform Abstract: Hydrogen Bonded Organic Nanotubes
Authors: Hou Jun‐Li
Published: June 2016

Review: application of hydrogen bonding in the construction of organic nanotubes; 62 rfs.
Katalysatoren des Leuna Werkes von 1960 – 1986: Von der Empirie zur Wissenschaft. Teil IV: Hydrospaltkatalysatoren
Authors: Becker Karl
Published: June 2016

In der vierteiligen Beitragsreihe wurde die Entwicklung technischer Katalysatoren im Leuna Werk dargestellt. Wenngleich die Arbeiten mit mehr als 300 Patenten verbunden waren, ist es nicht das Ziel, ein Patentrezept für die Entwicklung neuer Katalysatoren zu vermitteln, sondern zu zeigen, dass im Zuge der Katalysator‐ und Verfahrensentwicklungen in Leuna von den 1950er bis zum Ende der 1980er Jahre beachtliche Leistungen vollbracht wurden, die internationalen Vergleichen standhalten konnten. Neben dem wirtschaftlichen Nutzen von mehreren hundert Millionen Mark (DDR) wurden im Rahmen der Arbeiten neue Vorstellungen darüber entwickelt, was ein technischer Katalysator ist und wie er wirkt. Der vierte und letzte Teil befasst sich mit den Hydrospaltkatalysatoren sowie den in der DDR entwickelten Verfahren.
Evaluation of Dye Adsorption Onto SBA‐15 Using Image Analysis
Authors: Nesic Aleksandra R. , Kokunesoski Maja J. , Meseldzija Sladjana S. , Volkov‐Husovic Tatjana D. , Velickovic Sava J. , Onjia Antonije E.
Published: June 2016

In this work, the reliability of image analysis for the numerical evaluation of Basic Red 46 (BR 46) dye adsorption process was studied. The image analysis was carried out on dye adsorbed onto SBA‐15 mesoporous silica, by use of Image‐Pro Plus software. Pixel‐specific calibration curves were derived and used to obtain dye concentration from the three different primary color channels (red, green, and blue) recorded at each pixel. In order to establish credibility of this method for quantification of adsorption processes, these data were compared with dye adsorption parameters obtained by UV‐vis analysis. Among the three different primary color channels, the best results were obtained when the blue color channel was applied. In this case, the average relative error was 0.86%. The obtained results showed that a dye adsorbed on SBA‐15 can be determined with the use of Image‐Pro Plus with the same sensitivity as with the use of spectrophotometric analysis for the determination of changes in dye concentration during the adsorption process.
Childhood leukemia incidence in California: High and rising in the Hispanic population
Authors: Giddings Brenda M. , Whitehead Todd P. , Metayer Catherine , Miller Mark D.
Published: June 2016

BACKGROUND

High rates of childhood leukemia incidence have been reported in Latin America and among Hispanic children in the United States. California's large Hispanic population affords an important opportunity to perform a detailed analysis of the leukemia burden among Hispanic children.

METHODS

Leukemias diagnosed among non‐Hispanic white (NHW), Hispanic, African American (AA), and Asian/Pacific Islander (API) children aged birth to 19 years between January 1, 1990 and December 31, 2012 were obtained from the California Cancer Registry (11,084 cases). Age‐adjusted incidence rates, standardized rate ratios (SRRs), and secular trends in incidence (annual percent change [APC]) were analyzed by subtype, race/ethnicity, sex, and age.

RESULTS

Compared with NHW children, the incidence of acute lymphoblastic leukemia (ALL) was higher among Hispanic (SRR, 1.32) and lower among AA (SRR, 0.55) and API (SRR, 0.91) children. From 1990 to 2012, the incidence of ALL increased overall (APC, 1.1%) and among males (APC, 1.0%), females (APC, 1.3%), Hispanics (APC, 1.1%), AAs (APC, 1.9%), AA males (APC, 2.8%), API males (APC, 1.9%), and Hispanic females (APC, 1.5%). The incidence of ALL increased among Hispanic males aged 15 to 19 years (APC, 2.5%) and Hispanic females aged birth to 4 years and 15 to 19 years (APCs of 2.2% and 1.9%, respectively). The incidence of acute myeloid leukemia did not appear to differ among racial/ethnic groups. From 1990 to 2012, the overall incidence of acute myeloid leukemia remained stable but increased among Hispanics (APC, 1.2%), females (APC, 1.0%), Hispanic females (APC, 2.3%), and Hispanic females aged 15 to 19 years (APC, 3.4%).

CONCLUSIONS

Notable differences in the incidence of childhood leukemia were observed among 4 racial/ethnic groups in California. Factors that may contribute to these differences include differential exposure to carcinogens and/or genetic susceptibility. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2867–2875. © 2016 American Cancer Society
Randomized phase 3 study in low‐grade lymphoma comparing maintenance anti‐CD20 antibody with observation after induction therapy: A trial of the ECOG‐ACRIN Cancer Research Group (E1496)
Authors: Barta Stefan K. , Li Hailun , Hochster Howard S. , Hong Fangxin , Weller Edie , Gascoyne Randy D. , Habermann Thomas M. , Gordon Leo I. , Colocci Natalia , Bengtson Elizabeth M. , Horning Sandra J. , Kahl Brad S.
Published: June 2016

BACKGROUND

In an ECOG‐ACRIN Cancer Research Group study (E1496), maintenance rituximab (MR) was reported to prolong progression‐free survival (PFS) in comparison with observation (OBS) alone in patients with indolent lymphoma after induction chemotherapy. Here the long‐term follow‐up of the same patient cohort is presented.

METHODS

Patients with indolent lymphoma received induction chemotherapy with cyclophosphamide, vincristine, and prednisone (CVP). Patients with stable disease or a better response were then randomized to weekly rituximab (375 mg/m2 × 4 doses) every 6 months for 2 years (MR) or to OBS. The primary endpoint was PFS; the secondary endpoints were overall survival (OS), response rate, and toxicities.

RESULTS

Of the 387 patients who initially received CVP induction, 158 were randomized to MR, and 153 were randomized to OBS. After a median follow‐up of 11.5 years, patients on MR had longer median PFS (4.8 years) than patients on OBS (1.3 years; hazard ratio [HR], 0.49; P < .0001). However, there was no difference in OS between MR and OBS (10‐year OS, 67% vs 59%; median OS, 13.5 years vs not reached; HR, 0.91; P = .69). Other than MR, only minimal residual disease after induction therapy was significantly associated with PFS on multivariate analysis (HR, 0.71; P = .02). A low initial tumor burden, minimal residual disease, follicular histology, a low Follicular Lymphoma International Prognostic Index score, and female sex were associated with longer OS. There was no increase in the rate of second primary malignancies with MR vs OBS.

CONCLUSIONS

With long‐term follow‐up, MR did not influence OS. The PFS benefit was maintained. MR should be considered optional for patients with indolent B‐cell lymphoma. Cancer 2016;122:2996‐3004. © 2016 American Cancer Society.
A Luminescent Nanocrystal Marker for the Selective and Ultrasensitive Detection of Explosives
Authors: Sarkar Shyam , Graña‐Suárez Laura , Verboom Willem , Mahalingam Venkataramanan , Huskens Jurriaan
Published: June 2016

We developed a luminescent probe for the selective and sensitive detection of an explosive, i.e., picric acid (PA), based on the luminescence quenching of CeIII and TbIII co‐doped Sr2GdF7 nanocrystals. A new colloidal synthesis route at low temperature (80 °C) was developed to synthesize the luminescent nanocrystals host matrix Sr2GdF7. The nanocrystals showed strong green emission under UV excitation (290 nm) by efficient energy transfer from CeIII to TbIII ions. The functionalization of the nanocrystals with l‐cysteine (Cys) rendered the luminescent probe water dispersible. The presence of the −NH2 groups of Cys allowed the selective interaction of the probe with PA among other nitro explosives. This caused a 92 % reduction of the photoluminescence intensity of TbIII in the Sr2GdF7 nanocrystals, and led to the selective detection of PA with an unprecedented limit of detection (LOD) of approx. 4 nm.
Identification and analytical characterization of four synthetic cathinone derivatives iso‐4‐BMC, β‐TH‐naphyrone, mexedrone, and 4‐MDMC
Authors: Qian Zhenhua , Jia Wei , Li Tao , Liu Cuimei , Hua Zhendong
Published: June 2016

New psychoactive substances (NPS) have gained much popularity on the global market over the last number of years. The synthetic cathinone family is one of the most prominent groups and this paper reports on the analytical properties of four synthetic cathinone derivatives: (1) 1‐(4‐bromophenyl)‐1‐(methylamino)propan‐2‐one (iso‐4‐BMC or iso‐brephedrone), (2) 2‐(pyrrolidin‐1‐yl)‐1‐(5,6,7,8‐tetrahydronaphthalen‐2‐yl)pentan‐1‐one (β‐TH‐naphyrone), (3) 3‐methoxy‐2‐(methylamino)‐1‐(4‐methylphenyl)propan‐1‐one (mexedrone), and (4) 2‐(dimethylamino)‐1‐(4‐methylphenyl)propan‐1‐one (4‐MDMC). These identifications were based on liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry (LC‐QTOF‐MS), gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance (NMR) spectroscopy. To our knowledge, no chemical or pharmacological data about compounds 1–3 have appeared until now, making this the first report on these compounds. The Raman and GC‐MS data of 4 have been reported, but this study added the LC‐MS and NMR data for additional characterization. Copyright © 2016 John Wiley & Sons, Ltd.
Leaf litter arthropod responses to tropical forest restoration
Authors: Cole Rebecca J. , Holl Karen D. , Zahawi Rakan A. , Wickey Philipp , Townsend Alan R.
Published: June 2016

Soil and litter arthropods represent a large proportion of tropical biodiversity and perform important ecosystem functions, but little is known about the efficacy of different tropical forest restoration strategies in facilitating their recovery in degraded habitats. We sampled arthropods in four 7‐ to 8‐year‐old restoration treatments and in nearby reference forests. Sampling was conducted during the wet and dry seasons using extractions from litter and pitfall samples. Restoration treatments were replicated in 50 × 50‐m plots in four former pasture sites in southern Costa Rica: plantation – trees planted throughout the plot; applied nucleation/islands – trees planted in patches of different sizes; and natural regeneration – no tree planting. Arthropod abundance, measures of richness and diversity, and a number of functional groups were greater in the island treatment than in natural regeneration or plantation treatments and, in many cases, were similar to reference forest. Litter and pitfall morphospecies and functional group composition in all three restoration treatments were significantly different than reference sites, but island and plantation treatments showed more recovery than natural regeneration. Abundance and functional group diversity showed a much greater degree of recovery than community composition. Synthesis and applications: The less resource‐intensive restoration strategy of planting tree islands was more effective than tree plantations in restoring arthropod abundance, richness, and functional diversity. None of the restoration strategies, however, resulted in similar community composition as reference forest after 8 years of recovery, highlighting the slow rate of recovery of arthropod communities after disturbance, and underscoring the importance of conservation of remnant forests in fragmented landscapes.
Into the deep: the functionality of mesopelagic excursions by an oceanic apex predator
Authors: Howey Lucy A. , Tolentino Emily R. , Papastamatiou Yannis P. , Brooks Edward J. , Abercrombie Debra L. , Watanabe Yuuki Y. , Williams Sean , Brooks Annabelle , Chapman Demian D. , Jordan Lance K.B.
Published: June 2016

Comprehension of ecological processes in marine animals requires information regarding dynamic vertical habitat use. While many pelagic predators primarily associate with epipelagic waters, some species routinely dive beyond the deep scattering layer. Actuation for exploiting these aphotic habitats remains largely unknown. Recent telemetry data from oceanic whitetip sharks (Carcharhinus longimanus) in the Atlantic show a strong association with warm waters (>20°C) less than 200 m. Yet, individuals regularly exhibit excursions into the meso‐ and bathypelagic zone. In order to examine deep‐diving behavior in oceanic whitetip sharks, we physically recovered 16 pop‐up satellite archival tags and analyzed the high‐resolution depth and temperature data. Diving behavior was evaluated in the context of plausible functional behavior hypotheses including interactive behaviors, energy conservation, thermoregulation, navigation, and foraging. Mesopelagic excursions (n = 610) occurred throughout the entire migratory circuit in all individuals, with no indication of site specificity. Six depth‐versus‐time descent and ascent profiles were identified. Descent profile shapes showed little association with examined environmental variables. Contrastingly, ascent profile shapes were related to environmental factors and appear to represent unique behavioral responses to abiotic conditions present at the dive apex. However, environmental conditions may not be the sole factors influencing ascents, as ascent mode may be linked to intentional behaviors. While dive functionality remains unconfirmed, our study suggests that mesopelagic excursions relate to active foraging behavior or navigation. Dive timing, prey constituents, and dive shape support foraging as the most viable hypothesis for mesopelagic excursions, indicating that the oceanic whitetip shark may regularly survey extreme environments (deep depths, low temperatures) as a foraging strategy. At the apex of these deep‐water excursions, sharks exhibit a variable behavioral response, perhaps, indicating the presence or absence of prey.
Life after cold death: reef coral and coral reef responses to the 2010 cold water anomaly in the Florida Keys
Authors: Kemp Dustin W. , Colella Michael A. , Bartlett Lucy A. , Ruzicka Rob R. , Porter James W. , Fitt William K.
Published: June 2016

Organismal and community‐wide responses of reef‐building corals are documented before and after a severe cold‐water thermal anomaly that occurred in 2010 in the Florida Keys, USA. In January 2010 seawater temperatures dropped far below the normal minima (to <11°C), resulting in the largest documented coral mass mortality event ever recorded in the Florida Keys. Physiological measurements demonstrated species‐specific thermal sensitivities to this environmental perturbation. Four common corals with narrow thermal tolerance, Acropora cervicornis, Orbicella annularis, O. faveolata, and Porites astreoides, sustained high mortality (>80%) on inshore reefs. In contrast, another common coral with a wide thermal tolerance, Siderastrea siderea, was not affected by this cold anomaly. We measured biomass, symbiotic algal densities (genus: Symbiodinium), chlorophyll a content, and maximum quantum efficiency of photosystem II for reef‐building corals on a seasonal basis before and after the 2010 cold anomaly. Our data document a clear correspondence between physiological response, biomass levels, and survivorship among these five scleractinian coral species. These physiological findings are mirrored by in‐shore benthic community monitoring data, which show the dramatic loss of the three cold‐sensitive species and continued survival of the cold‐tolerant species. Finally, we document recruitment and survival rates of newly settled reef‐building corals on four inshore reefs, which experienced high coral mortality during the 2010 cold‐kill. Interestingly, both a cold‐tolerant species, S. siderea, and a cold‐intolerant species, P. astreoides, were the most abundant species recruiting to these postdisturbance reefs.