bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 2 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
Authors: Rader JulieAnn , Russell Mike R. , Hart Lori S. , Nakazawa Michael S. , Belcastro Lili T. , Martinez Daniel , Li Yimei , Carpenter Erica L. , Attiyeh Edward F. , Diskin Sharon J. , Kim Sunkyu , Parasuraman Sudha , Caponigro Giordano , Schnepp Robert W. , Wood Andrew C. , Pawel Bruce , Cole Kristina A. , Maris John M.
Published: April 2023

Supplementary Table 2 - PDF file 48KB, Copy number variations within the Cyclin D/CDK4/CDK6/RB pathway occur in high-risk neuroblastoma patients
Supplementary Table 1 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
Authors: Rader JulieAnn , Russell Mike R. , Hart Lori S. , Nakazawa Michael S. , Belcastro Lili T. , Martinez Daniel , Li Yimei , Carpenter Erica L. , Attiyeh Edward F. , Diskin Sharon J. , Kim Sunkyu , Parasuraman Sudha , Caponigro Giordano , Schnepp Robert W. , Wood Andrew C. , Pawel Bruce , Cole Kristina A. , Maris John M.
Published: April 2023

Supplementary Table 1 - PDF file 78K, Genomic aberrations in the Cyclin D/CDK4/CDK6/RB pathway occur frequently in neuroblastoma cell lines
Supplementary Figure 5 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
Authors: Rader JulieAnn , Russell Mike R. , Hart Lori S. , Nakazawa Michael S. , Belcastro Lili T. , Martinez Daniel , Li Yimei , Carpenter Erica L. , Attiyeh Edward F. , Diskin Sharon J. , Kim Sunkyu , Parasuraman Sudha , Caponigro Giordano , Schnepp Robert W. , Wood Andrew C. , Pawel Bruce , Cole Kristina A. , Maris John M.
Published: April 2023

Supplementary Figure 5 - PDF file 138K, CDK4/6 inhibition does not induce cytotoxicity in neuroblastoma. (A) Caspase 3/7 activation and (B) PARP cleavage were not observed in cell lines with demonstrated sensitivity to LEE011. SN38, a known cytotoxic agent, was used as a positive control
Supplementary Figure 3 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
Authors: Rader JulieAnn , Russell Mike R. , Hart Lori S. , Nakazawa Michael S. , Belcastro Lili T. , Martinez Daniel , Li Yimei , Carpenter Erica L. , Attiyeh Edward F. , Diskin Sharon J. , Kim Sunkyu , Parasuraman Sudha , Caponigro Giordano , Schnepp Robert W. , Wood Andrew C. , Pawel Bruce , Cole Kristina A. , Maris John M.
Published: April 2023

Supplementary Figure 3 - PDF file 127K, MYCN expression is inversely correlated with LEE011 sensitivity. (A) High mRNA expression of MYCN correlates with low LEE011 IC50s (r = -0.55, p = 0.02). This correlation is further strengthened (r = -0.7, p = 0.003) by the removal of two outliers, SKNSH (IC50 = 148 nM) and its subclone, SY5Y (IC50 = 154 nM). (B) Sensitive cell lines also tend to express higher levels of MYCN protein than resistant cell lines
Supplementary Figure 2 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
Authors: Rader JulieAnn , Russell Mike R. , Hart Lori S. , Nakazawa Michael S. , Belcastro Lili T. , Martinez Daniel , Li Yimei , Carpenter Erica L. , Attiyeh Edward F. , Diskin Sharon J. , Kim Sunkyu , Parasuraman Sudha , Caponigro Giordano , Schnepp Robert W. , Wood Andrew C. , Pawel Bruce , Cole Kristina A. , Maris John M.
Published: April 2023

Supplementary Figure 2 - PDF file 55K, Neuroblastoma tissue microarray. A tissue microarray demonstrates expression of RB in neuroblastoma that is higher in high-risk and MYCN amplified samples compared to low-risk or non-amplified samples (p = 0.03)
Supplementary Figure Legend from A Novel Therapeutic Regimen to Eradicate Established Solid Tumors with an Effective Induction of Tumor-Specific Immunity
Authors: Tysome James R. , Li Xiaozhu , Wang Shengdian , Wang Pengju , Gao Dongling , Du Pan , Chen Dong , Gangeswaran Rathi , Chard Louisa S. , Yuan Ming , Alusi Ghassan , Lemoine Nicholas R. , Wang Yaohe
Published: April 2023

PDF file - 73K
Supplementary Table 1 from The Use of Quantitative Real-Time Reverse Transcriptase PCR for 5′ and 3′ Portions of ALK Transcripts to Detect ALK Rearrangements in Lung Cancers
Authors: Wang Rui , Pan Yunjian , Li Chenguang , Hu Haichuan , Zhang Yang , Li Hang , Luo Xiaoyang , Zhang Jie , Fang Zhaoyuan , Li Yuan , Shen Lei , Ji Hongbin , Garfield David , Sun Yihua , Chen Haiquan
Published: April 2023

PDF file, 36K, Primers for qRT-PCR.
Supplementary Figure 1 from A Novel Therapeutic Regimen to Eradicate Established Solid Tumors with an Effective Induction of Tumor-Specific Immunity
Authors: Tysome James R. , Li Xiaozhu , Wang Shengdian , Wang Pengju , Gao Dongling , Du Pan , Chen Dong , Gangeswaran Rathi , Chard Louisa S. , Yuan Ming , Alusi Ghassan , Lemoine Nicholas R. , Wang Yaohe
Published: April 2023

PDF file - 72K, DNA amplification of VVLister and Ad5 early and late genes in Syrian hamster tumor cell lines in vitro
Supplementary Figure 3 from The Use of Quantitative Real-Time Reverse Transcriptase PCR for 5′ and 3′ Portions of ALK Transcripts to Detect ALK Rearrangements in Lung Cancers
Authors: Wang Rui , Pan Yunjian , Li Chenguang , Hu Haichuan , Zhang Yang , Li Hang , Luo Xiaoyang , Zhang Jie , Fang Zhaoyuan , Li Yuan , Shen Lei , Ji Hongbin , Garfield David , Sun Yihua , Chen Haiquan
Published: April 2023

PDF file, 305K, Normalized mRNA expression in 3' portion in ALK-rearranged lung cancer samples with varied tumor content.
Supplementary Tables 1 - 5 from Expression Signature Defined by FOXM1–CCNB1 Activation Predicts Disease Recurrence in Non–Muscle-Invasive Bladder Cancer
Authors: Kim Seon-Kyu , Roh Yun-Gil , Park Kiejung , Kang Tae-Hong , Kim Wun-Jae , Lee Ju-Seog , Leem Sun-Hee , Chu In-Sun
Published: April 2023

PDF file - 49KB, Supplementary Table S1. Primer sequences of the genes for RT-PCR analysis. Supplementary Table S2. List of the genes and the number of their correlated genes strongly associated with recurrence of NMIBC. Supplementary Table S3. Performance of prediction models. Supplementary Table S4. Multivariate Cox regression analysis for prediction of disease recurrence in the European cohort. Supplementary Table S5. Prediction of activated upstream regulators during recurrence of non-muscle invasive bladder cancer.
Supplementary Figure 5 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
Authors: Godbersen J. Claire , Humphries Leigh Ann , Danilova Olga V. , Kebbekus Peter E. , Brown Jennifer R. , Eastman Alan , Danilov Alexey V.
Published: April 2023

PDF file - 59KB, BMS-345541 leads to Bim upregulation in CLL. CLL cells (N=3) were co-cultured with CD40L-expressing stroma for 24 hours, followed by incubation with 2 - 12 microM BMS-345541 or vehicle control for 24 h. Cells were lysed and subjected to immunoblotting. 1 out of 3 representative images is shown.
Supplementary Legends from A NOTCH3 Transcriptional Module Induces Cell Motility in Neuroblastoma
Authors: van Nes Johan , Chan Alvin , van Groningen Tim , van Sluis Peter , Koster Jan , Versteeg Rogier
Published: April 2023

Supplementary Legends - PDF file 80K, This file contains the legends to supplementary figures, supplementary movies and supplementary tables
Supplementary Figures 1 - 5, Table 1 from Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
Authors: Selvakumaran Muthu , Amaravadi Ravi K. , Vasilevskaya Irina A. , O'Dwyer Peter J.
Published: April 2023

PDF file - 1198K, We have analyzed autophagy induction in colon cancer cells through TEM and studied the effect of HIF-1 alpha and ATG-5 inhibition in hypoxia-induced autophagy. We have analyzed the synergy between oxaliplatin and CQ on colon cancer cells cytotoxicity in hypoxic environments.
Supplementary Figure 2 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
Authors: Godbersen J. Claire , Humphries Leigh Ann , Danilova Olga V. , Kebbekus Peter E. , Brown Jennifer R. , Eastman Alan , Danilov Alexey V.
Published: April 2023

PDF file - 63KB, MLN4924 does not impair stroma viability or CD40L expression. Stromal cells were seeded in a 96 well plate at 5x10^4 cells/well and the next day treated with the indicated concentrations of MLN4924 in triplicate for 48 hours. Cell lysates were subjected to caspase activity measurement and immunoblotting.
Supplementary Figure 2 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
Authors: Godbersen J. Claire , Humphries Leigh Ann , Danilova Olga V. , Kebbekus Peter E. , Brown Jennifer R. , Eastman Alan , Danilov Alexey V.
Published: April 2023

MLN4924 does not impair stroma viability or CD40L expression. Stromal cells were seeded in a 96 well plate at 5x104 cells/well and the next day treated with the indicated concentrations of MLN4924 in triplicate for 48 hours. Cell lysates were subjected to caspase activity measurement and immunoblotting.
Supplementary Figure 1 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
Authors: Godbersen J. Claire , Humphries Leigh Ann , Danilova Olga V. , Kebbekus Peter E. , Brown Jennifer R. , Eastman Alan , Danilov Alexey V.
Published: April 2023

MLN4924-induces apoptosis of the CLL B-cells on CD40L-expressing stroma is independent of IGHV mutational status (A) and cytogenetics (B, C). CLL cells were cultured on CD40L-expressing stroma for 24 hours, followed by incubation with 1 ÃŽÂ¼M MLN4924 or vehicle control for 48 hours. Apoptosis within CD19+ subset of cells was determined by Annexin V and 7-AAD staining and normalized to the time-matched untreated controls. Horizontal lines represent the mean. (C) % apoptosis plotted against the size of a 17p deletion clone in 11 individual CLL samples (r=-0.2, p=0.56).
Related Article from The Power of Negative Thinking: Which Cells Limit Tumor Immunity?
Authors: Tang Siuwah , Lotze Michael T.
Published: April 2023

Related Article from The Power of Negative Thinking: Which Cells Limit Tumor Immunity?
Supplementary Figure Legend from Synergistic Activity of Bortezomib and HDACi in Preclinical Models of B-cell Precursor Acute Lymphoblastic Leukemia via Modulation of p53, PI3K/AKT, and NF-κB
Authors: Bastian Lorenz , Hof Jana , Pfau Madlen , Fichtner Iduna , Eckert Cornelia , Henze Günter , Prada Javier , von Stackelberg Arend , Seeger Karl , Shalapour Shabnam
Published: April 2023

PDF file - 56K
Supplementary Figure 3 from Systemic Administration of a Novel Immune-Stimulatory Pseudovirion Suppresses Lung Metastatic Melanoma by Regionally Enhancing IFN-γ Production
Authors: Saga Kotaro , Tamai Katsuto , Yamazaki Takehiko , Kaneda Yasufumi
Published: April 2023

PDF file - 58K, Sucrose gradient sedimentation of ZZ-scIL-12 and wt-HVJ-E.
Supplementary Table 1 from Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations
Authors: Dees E. Claire , Cohen Roger B. , von Mehren Margaret , Stinchcombe Thomas E. , Liu Hua , Venkatakrishnan Karthik , Manfredi Mark , Fingert Howard , Burris Howard A. , Infante Jeffrey R.
Published: April 2023

PDF file, 59K, Summary of pharmacokinetic parameters for MLN8237 PIC formulation after multiple dose oral administration dosing in the 7-, 14-, and 21-day schedules.
Supplementary Figure 2 from Systemic Administration of a Novel Immune-Stimulatory Pseudovirion Suppresses Lung Metastatic Melanoma by Regionally Enhancing IFN-γ Production
Authors: Saga Kotaro , Tamai Katsuto , Yamazaki Takehiko , Kaneda Yasufumi
Published: April 2023

PDF file - 69K, Inhibition of the F protein by the anti-F neutralizing antibody, and IFN-γ induction upon treatment with scIL-12-HVJ-E.
Related Article from BEAMing Up Personalized Medicine: Mutation Detection in Blood
Authors: Richardson Andrea L. , Iglehart J. Dirk
Published: April 2023

Related Article from BEAMing Up Personalized Medicine: Mutation Detection in Blood
Supplementary Table 3 from miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro
Authors: Mulrane Laoighse , Madden Stephen F. , Brennan Donal J. , Gremel Gabriela , McGee Sharon F. , McNally Sara , Martin Finian , Crown John P. , Jirström Karin , Higgins Desmond G. , Gallagher William M. , O'Connor Darran P.
Published: April 2023

PDF file - 73K, Association of clinicopathological characteristics of tumours with miR-187 expression in Cohort 1 (n=117) using Pearson's chi-squared test
Supplementary Materials and Methods from Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer
Authors: Zhang Geng , He Peijun , Tan Hanson , Budhu Anuradha , Gaedcke Jochen , Ghadimi B. Michael , Ried Thomas , Yfantis Harris G. , Lee Dong H. , Maitra Anirban , Hanna Nader , Alexander H. Richard , Hussain S. Perwez
Published: April 2023

Supplementary Materials and Methods - PDF file 88K, Additional description of materials and methods
Supplementary Legends from A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-κB
Authors: Gopalakrishnan Ramakrishnan , Matta Hittu , Chaudhary Preet M.
Published: April 2023

PDF file, 85K.
Supplemenary Material from First-in-Human Phase I Dose-Escalation Study of the HSP90 Inhibitor AUY922 in Patients with Advanced Solid Tumors
Authors: Sessa Cristiana , Shapiro Geoffrey I. , Bhalla Kapil N. , Britten Carolyn , Jacks Karen S. , Mita Monica , Papadimitrakopoulou Vali , Pluard Tim , Samuel Thomas A. , Akimov Mikhail , Quadt Cornelia , Fernandez-Ibarra Cristina , Lu Hong , Bailey Stuart , Chica Sandra , Banerji Udai
Published: April 2023

Supplementary Table 1. Baseline characteristics Supplementary Table 2. Criteria for defining dose-limiting toxicities.
Supplementary Figure 6 from Combined Targeting of STAT3/NF-κB/COX-2/EP4 for Effective Management of Pancreatic Cancer
Authors: Gong Jingjing , Xie Jianping , Bedolla Roble , Rivas Paul , Chakravarthy Divya , Freeman James W. , Reddick Robert , Kopetz Scott , Peterson Amanda , Wang Huamin , Fischer Susan M. , Kumar Addanki P.
Published: April 2023

PDF file - 733KB, Administration of Nx to BK5-Cox-2 mice had no significant effect on food consumption and mice body weight.
Related Article from Next-Generation Medicine: Combining BCR-ABL and Hedgehog-Targeted Therapies
Authors: Dao Kim-Hien T. , Tyner Jeffrey W.
Published: April 2023

Related Article from Next-Generation Medicine: Combining BCR-ABL and Hedgehog-Targeted Therapies
Supplementary Table S1 from A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor–Infiltrating Lymphocytes
Authors: Demotte Nathalie , Bigirimana René , Wieërs Grégoire , Stroobant Vincent , Squifflet Jean-Luc , Carrasco Javier , Thielemans Kris , Baurain Jean-François , Van Der Smissen Patrick , Courtoy Pierre J. , van der Bruggen Pierre
Published: April 2023

PDF file 105K, GM-CT-01 boosts secretion of various cytokines by TIL
Supplementary Figure 1 from Combined Targeting of STAT3/NF-κB/COX-2/EP4 for Effective Management of Pancreatic Cancer
Authors: Gong Jingjing , Xie Jianping , Bedolla Roble , Rivas Paul , Chakravarthy Divya , Freeman James W. , Reddick Robert , Kopetz Scott , Peterson Amanda , Wang Huamin , Fischer Susan M. , Kumar Addanki P.
Published: April 2023

PDF file - 679KB, NFkappaB and Stat3 binding sites in Cox-2 promoter.
Supplementary Fig. S3 from A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor–Infiltrating Lymphocytes
Authors: Demotte Nathalie , Bigirimana René , Wieërs Grégoire , Stroobant Vincent , Squifflet Jean-Luc , Carrasco Javier , Thielemans Kris , Baurain Jean-François , Van Der Smissen Patrick , Courtoy Pierre J. , van der Bruggen Pierre
Published: April 2023

PDF file 114K, In contrast to LacNAc, GM-CT-01 does not detach galectin-1 and galectin-3 from melanoma cell surface
Supplementary Fig. S1 from A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor–Infiltrating Lymphocytes
Authors: Demotte Nathalie , Bigirimana René , Wieërs Grégoire , Stroobant Vincent , Squifflet Jean-Luc , Carrasco Javier , Thielemans Kris , Baurain Jean-François , Van Der Smissen Patrick , Courtoy Pierre J. , van der Bruggen Pierre
Published: April 2023

PDF file 98K, Influence of GM-CT-01 on T cell and melanoma cell growth
Supplementary Methods from Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
Authors: Yin Shaoman , Kaluz Stefan , Devi Narra S. , Jabbar Adnan A. , de Noronha Rita G. , Mun Jiyoung , Zhang Zhaobin , Boreddy Purushotham R. , Wang Wei , Wang Zhibo , Abbruscato Thomas , Chen Zhengjia , Olson Jeffrey J. , Zhang Ruiwen , Goodman Mark M. , Nicolaou K.C. , Van Meir Erwin G.
Published: April 2023

PDF file, 88K.
Supplementary Figure Legend from Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
Authors: Yin Shaoman , Kaluz Stefan , Devi Narra S. , Jabbar Adnan A. , de Noronha Rita G. , Mun Jiyoung , Zhang Zhaobin , Boreddy Purushotham R. , Wang Wei , Wang Zhibo , Abbruscato Thomas , Chen Zhengjia , Olson Jeffrey J. , Zhang Ruiwen , Goodman Mark M. , Nicolaou K.C. , Van Meir Erwin G.
Published: April 2023

PDF file, 106K.
Supplementary Figure 2 from Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms
Authors: Singh Jagdeep K. , Farnie Gillian , Bundred Nigel J. , Simões Bruno M , Shergill Amrita , Landberg Göran , Howell Sacha J. , Clarke Robert B.
Published: April 2023

PDF file - 94K, Supplementary Figure 2. IL-8 induced mammosphere formation in SKBR3 cells is dependent on activation of EGFR and AKT signalling pathways.
Supplementary Figure 1 from Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms
Authors: Singh Jagdeep K. , Farnie Gillian , Bundred Nigel J. , Simões Bruno M , Shergill Amrita , Landberg Göran , Howell Sacha J. , Clarke Robert B.
Published: April 2023

PDF file - 106K, Supplementary Figure 1. CXCR1/2 and EGFR/HER2 regulate mammosphere formation/self-renewal and the proportion of aldefluor positive cell in HER2 positive breast cancer cell lines.
Supplementary Figure 2 from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein
Authors: Veomett Nicholas , Dao Tao , Liu Hong , Xiang Jingyi , Pankov Dmitry , Dubrovsky Leonid , Whitten Joseph A. , Park Sun-Mi , Korontsvit Tatyana , Zakhaleva Victoria , Casey Emily , Curcio Michael , Kharas Michael G. , O'Reilly Richard J. , Liu Cheng , Scheinberg David A.
Published: April 2023

PDF file - 142KB, Human PBMCs were separated into effector cell populations and tested for in vitro ADCC activity against BV173 cells, mediated by ESKM or isotype control mAb. Only fractionated NK cells showed activity relative to isotype control antibody. % Lysis is calculated based on spontaneous release (target cells, no effectors or mAb) as 0% and maximal release (target cells + SDS) as 100%.
Supplementary Table 3 from Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma
Authors: Borger Darrell R. , Goyal Lipika , Yau Thomas , Poon Ronnie T. , Ancukiewicz Marek , Deshpande Vikram , Christiani David C. , Liebman Hannah M. , Yang Hua , Kim Hyeryun , Yen Katharine , Faris Jason E. , Iafrate A. John , Kwak Eunice L. , Clark Jeffrey W. , Allen Jill N. , Blaszkowsky Lawrence S. , Murphy Janet E. , Saha Supriya K. , Hong Theodore S. , Wo Jennifer Y. , Ferrone Cristina R. , Tanabe Kenneth K. , Bardeesy Nabeel , Straley Kimberly S. , Agresta Sam , Schenkein David P. , Ellisen Leif W. , Ryan David P. , Zhu Andrew X.
Published: April 2023

PDF file - 57KB, Levels of serum 2HG relative to tumor burden in IDH1-mutant and IDH2-mutant intrahepatic cholangiocarcinoma patients in the Validation cohort.
Supplementary Table 1 from Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma
Authors: Borger Darrell R. , Goyal Lipika , Yau Thomas , Poon Ronnie T. , Ancukiewicz Marek , Deshpande Vikram , Christiani David C. , Liebman Hannah M. , Yang Hua , Kim Hyeryun , Yen Katharine , Faris Jason E. , Iafrate A. John , Kwak Eunice L. , Clark Jeffrey W. , Allen Jill N. , Blaszkowsky Lawrence S. , Murphy Janet E. , Saha Supriya K. , Hong Theodore S. , Wo Jennifer Y. , Ferrone Cristina R. , Tanabe Kenneth K. , Bardeesy Nabeel , Straley Kimberly S. , Agresta Sam , Schenkein David P. , Ellisen Leif W. , Ryan David P. , Zhu Andrew X.
Published: April 2023

PDF file - 67KB, Characteristics of all intrahepatic cholangiocarcinoma patients evaluated across the two cohorts.
Supplementary Figure Legend from Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
Authors: Zimmerman Eric I. , Hu Shuiying , Roberts Justin L. , Gibson Alice A. , Orwick Shelley J. , Li Lie , Sparreboom Alex , Baker Sharyn D.
Published: April 2023

PDF file - 109K
Supplementary Methods from Combined PET/MRI Improves Diagnostic Accuracy in Patients with Prostate Cancer: A Prospective Diagnostic Trial
Authors: Hartenbach Markus , Hartenbach Sabrina , Bechtloff Winfried , Danz Burkhardt , Kraft Klaus , Klemenz Burkhard , Sparwasser Christoph , Hacker Marcus
Published: April 2023

PDF file - 103KB
Supplementary Figures 1 - 8, Table 1 from Positron Emission Tomography Imaging with 18F-Labeled ZHER2:2891 Affibody for Detection of HER2 Expression and Pharmacodynamic Response to HER2-Modulating Therapies
Authors: Trousil Sebastian , Hoppmann Susan , Nguyen Quang-Dé , Kaliszczak Maciej , Tomasi Giampaolo , Iveson Peter , Hiscock Duncan , Aboagye Eric O.
Published: April 2023

PDF file - 999K, Supplementary Figure S1: Scheme of FASTlab-compatible automated synthesis of 18FGE-226. Supplementary Figure S2. Interaction of GE-226 with HER2 as determined by Surface Plasmon Resonance. Supplementary Figure S3: Tracer uptake is dependent on specific radioactivity in SKOV-3 cells. Supplementary Figure S4: Plasma metabolite profile and tissue pharmacokinetics of 18FGE-226. Supplementary Figure S5: Specificity of 18FGE-226 receptor interaction determined by blocking studies, differential tumor uptake and kinetic modeling. Supplementary Figure S6: Influence of trastuzumab on heart and kidney pharmacokinetics. Supplementary Figure S7: HER2 expression analysis and genomic DNA sequencing in relation to uptake rate constants in trastuzumab-treated or control xenografts. Supplementary Figure S8: 18FGE-226 uptake and HER2 expression in response to HSP90 inhibition. Supplementary Table S1: Biodistribution of 18FGE-226 in tumor-bearing BALB/c nude mice. Supplementary Method: Procedures for synthesis of fluorescein labeled GE-226, surface plasmon resonance, western blotting, biodistribution, metabolic stability, small animal models for fluorescent GE-226 experiments, immunohistochemistry, ELISA and sequencing.
Supplementary Table 3 from CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids
Authors: Swarts Dorian R.A. , Henfling Mieke E.R. , Van Neste Leander , van Suylen Robert-Jan , Dingemans Anne-Marie C. , Dinjens Winand N.M. , Haesevoets Annick , Rudelius Martina , Thunnissen Erik , Volante Marco , Van Criekinge Wim , van Engeland Manon , Ramaekers Frans C.S. , Speel Ernst-Jan M.
Published: April 2023

XLSX file - 185K, Significance levels (P-values) for uni- and multivariate analyses (Cox-regression) of pulmonary neuroendocrine tumor subgroups, indicating the relation of clinical and molecular parameters with disease outcome
Supplementary Table 2 from CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids
Authors: Swarts Dorian R.A. , Henfling Mieke E.R. , Van Neste Leander , van Suylen Robert-Jan , Dingemans Anne-Marie C. , Dinjens Winand N.M. , Haesevoets Annick , Rudelius Martina , Thunnissen Erik , Volante Marco , Van Criekinge Wim , van Engeland Manon , Ramaekers Frans C.S. , Speel Ernst-Jan M.
Published: April 2023

XLSX file - 17K, Comparison of gene expression levels (quantitative RT-PCR) and protein expression levels (immunohistochemistry) of CD44, OTP and RET in pulmonary neuroendocrine tumours
Supplementary Figure 1 from The Activation of MAPK in Melanoma Cells Resistant to BRAF Inhibition Promotes PD-L1 Expression That Is Reversible by MEK and PI3K Inhibition
Authors: Jiang Xiaofeng , Zhou Jun , Giobbie-Hurder Anita , Wargo Jennifer , Hodi F. Stephen
Published: April 2023

PDF file - 198K, Signalng pathways that influence PD-L1 expression
Supplementary Figure Legend and Tables 1 - 4 from CpG Island Methylator Phenotype–Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis
Authors: Fu Tao , Pappou Emmanouil P. , Guzzetta Angela A. , Jeschke Jana , Kwak Ruby , Dave Pujan , Hooker Craig M. , Morgan Richard , Baylin Stephen B. , Iacobuzio-Donahue Christine A. , Wolfgang Christopher L. , Ahuja Nita
Published: April 2023

PDF file, 113K, Supplementary Figure Legend; Supplementary Table S1. List of primers used for methylation-specific PCR; S 2. List of KRAS mutations in patients with duodenal Adenocarcinomas; S3. Five year and 10 year cumulative proportion of overall survival and time-to-recurrence for different molecular groups; S4. Univariate and multivariate Cox proportional hazard analysis of overall survival and time-to-recurrence for CIMP, MLH1 methylation or MSI status.
Figure S3B from Identification of Transcriptional Subgroups in EGFR-Mutated and EGFR/KRAS Wild-Type Lung Adenocarcinoma Reveals Gene Signatures Associated with Patient Outcome
Authors: Planck Maria , Isaksson Sofi , Veerla Srinivas , Staaf Johan
Published: April 2023

Figure S3B - PDF file 8633K, Expression pattern of wt/wt-1/2 multicohort centroid genes across included adenocarcinoma cohorts
Supplementary Tables from Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer
Authors: Dennison Jennifer B. , Molina Jennifer R. , Mitra Shreya , González-Angulo Ana M. , Balko Justin M. , Kuba María G. , Sanders Melinda E. , Pinto Joseph A. , Gómez Henry L. , Arteaga Carlos L. , Brown Robert E. , Mills Gordon B.
Published: April 2023

Supplementary Tables - PDF file 148K, Table S1. Characteristics of HER2-negative breast cancers, separated by HR status, TCGA Table S2. Characteristics of triple-negative breast cancers with residual disease post neoadjuvant chemotherapy and univariate Table S3. Bimodal analysis of metabolism-related genes ranked by bimodality index (BI)
Supplementary Figure Legend from Effective Anti-Neu–Initiated Antitumor Responses Require the Complex Role of CD4+ T Cells
Authors: Mortenson Eric D. , Park SaeGwang , Jiang Zhujun , Wang Shengdian , Fu Yang-Xin
Published: April 2023

PDF file - 62K
Supplementary Table 2 from Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11
Authors: Drayton Ross M. , Dudziec Ewa , Peter Stefan , Bertz Simone , Hartmann Arndt , Bryant Helen E. , Catto James WF.
Published: April 2023

PDF file - 36KB, Tumour, patient information and SLC7A11 protein expression data from the 215 patient cohort used to generate figure 6 c, d.
Supplementary Figure 6 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis
Authors: Zhuo Wei , Jia Lin , Song Nan , Lu Xin-an , Ding Yanping , Wang Xiaofeng , Song Xiaomin , Fu Yan , Luo Yongzhang
Published: April 2023

PDF file - 1.4MB, The combination of both anti-CXCL12 and anti-VEGF-C blocking antibodies inhibits tumor growth
Supplementary Figure 5 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis
Authors: Zhuo Wei , Jia Lin , Song Nan , Lu Xin-an , Ding Yanping , Wang Xiaofeng , Song Xiaomin , Fu Yan , Luo Yongzhang
Published: April 2023

PDF file - 1.7MB, The combination effect of CXCL12 and VEGF-C on the migration of mLECs
Supplementary Figure 4 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis
Authors: Zhuo Wei , Jia Lin , Song Nan , Lu Xin-an , Ding Yanping , Wang Xiaofeng , Song Xiaomin , Fu Yan , Luo Yongzhang
Published: April 2023

PDF file - 1.4MB, Knocking-down Akt1 dramatically abolishes the effect of CXCL12 on the migration of mLECs
Supplementary Figure 6 from Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer
Authors: Skor Maxwell N. , Wonder Erin L. , Kocherginsky Masha , Goyal Anju , Hall Ben A. , Cai Yi , Conzen Suzanne D.
Published: April 2023

Supplementary Figure 6 - PDF file 1359K, Western analysis of GR isoforms from MDA-MB-231 xenografts
Supplementary Figure 1 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis
Authors: Zhuo Wei , Jia Lin , Song Nan , Lu Xin-an , Ding Yanping , Wang Xiaofeng , Song Xiaomin , Fu Yan , Luo Yongzhang
Published: April 2023

PDF file - 2.4MB, Analysis of the expression of chemokine receptors in cultured mLECs
Supplementary Figure 3 from CD133+ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide
Authors: Banerjee Sulagna , Nomura Alice , Sangwan Veena , Chugh Rohit , Dudeja Vikas , Vickers Selwyn M. , Saluja Ashok
Published: April 2023

PDF file - 184KB, CD133+ population formed serially transplantable tumors.
Related Article from Harnessing Immune Responses in the Tumor Microenvironment: All Signals Needed
Authors: Le Dung T. , Jaffee Elizabeth M.
Published: April 2023

Related Article from Harnessing Immune Responses in the Tumor Microenvironment: All Signals Needed
Supplementary Figure 3 from Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors
Authors: Cervantes Andres , Elez Elena , Roda Desamparados , Ecsedy Jeffrey , Macarulla Teresa , Venkatakrishnan Karthik , Roselló Susana , Andreu Jordi , Jung JungAh , Sanchis-Garcia Juan Manuel , Piera Adelaida , Blasco Inma , Maños Laura , Pérez-Fidalgo José-Alejandro , Fingert Howard , Baselga Jose , Tabernero Josep
Published: April 2023

PDF file, 2001K, Figure S3. Changes in skin apoptotic index on days 7, 14 and 21.
Supplementary Figure Legends from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia
Authors: Sánchez-Sánchez Beatriz , Gutiérrez-Herrero Sara , López-Ruano Guillermo , Prieto-Bermejo Rodrigo , Romo-González Marta , Llanillo Marcial , Pandiella Atanasio , Guerrero Carmen , Miguel Jesús F. San , Sánchez-Guijo Fermín , del Cañizo Consuelo , Hernández-Hernández Angel
Published: April 2023

PDF file - 112KB
Supplementary Figure Legend from Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma
Authors: Menzies Alexander M. , Haydu Lauren E. , Visintin Lydia , Carlino Matteo S. , Howle Julie R. , Thompson John F. , Kefford Richard F. , Scolyer Richard A. , Long Georgina V.
Published: April 2023

PDF file, 55KB.
Supplementary Figure 8 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia
Authors: Sánchez-Sánchez Beatriz , Gutiérrez-Herrero Sara , López-Ruano Guillermo , Prieto-Bermejo Rodrigo , Romo-González Marta , Llanillo Marcial , Pandiella Atanasio , Guerrero Carmen , Miguel Jesús F. San , Sánchez-Guijo Fermín , del Cañizo Consuelo , Hernández-Hernández Angel
Published: April 2023

PDF file - 87KB, Supplementary Figure 8. Inhibitors of NADPH oxidases and Flt3-ITD synergize to prevent the proliferation of two different AML cell lines.
Supplementary Figure 5 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia
Authors: Sánchez-Sánchez Beatriz , Gutiérrez-Herrero Sara , López-Ruano Guillermo , Prieto-Bermejo Rodrigo , Romo-González Marta , Llanillo Marcial , Pandiella Atanasio , Guerrero Carmen , Miguel Jesús F. San , Sánchez-Guijo Fermín , del Cañizo Consuelo , Hernández-Hernández Angel
Published: April 2023

PDF file - 340KB, Supplementary figure 5. Combination of NADPH oxidases and BCR-ABL inhibitors progressively increases the proportion of sub-G1 phase cells.
Supplementary Figure 2 Legend from Synergistic Effects of Metformin Treatment in Combination with Gefitinib, a Selective EGFR Tyrosine Kinase Inhibitor, in LKB1 Wild-type NSCLC Cell Lines
Authors: Morgillo Floriana , Sasso Ferdinando Carlo , Della Corte Carminia Maria , Vitagliano Donata , D'Aiuto Elena , Troiani Teresa , Martinelli Erika , De Vita Ferdinando , Orditura Michele , De Palma Raffaele , Ciardiello Fortunato
Published: April 2023

Supplementary Figure 2 Legend - PDF file 58K, Supplementary Figure 2 legend: Effects on the downstream pathways by metformin treatment in A549 and H460. Western blotting analysis of AMPK, ACC, MAPK, AKT, p70S6K, S6, 4EBP1, activation following treatment with the indicated concentration of metformin. beta-actin was included as a loading control
Supplementary Figure 1 from Synergistic Effects of Metformin Treatment in Combination with Gefitinib, a Selective EGFR Tyrosine Kinase Inhibitor, in LKB1 Wild-type NSCLC Cell Lines
Authors: Morgillo Floriana , Sasso Ferdinando Carlo , Della Corte Carminia Maria , Vitagliano Donata , D'Aiuto Elena , Troiani Teresa , Martinelli Erika , De Vita Ferdinando , Orditura Michele , De Palma Raffaele , Ciardiello Fortunato
Published: April 2023

Supplementary Figure 1 - PDF file 81K, Effects on CALU-3, CALU-3 GEF-R, H1299, H1975 and GLC82 cell growth of the combination of metformin and gefitinib
Supplementary Table 2 from A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer
Authors: Singel Stina Mui , Cornelius Crystal , Batten Kimberly , Fasciani Gail , Wright Woodring E. , Lum Lawrence , Shay Jerry W.
Published: April 2023

PDF File - 77K, Descriptive statistics of IC50 determinations of MDA-MB-231 cells to docetaxel.
Supplementary Legends from A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer
Authors: Singel Stina Mui , Cornelius Crystal , Batten Kimberly , Fasciani Gail , Wright Woodring E. , Lum Lawrence , Shay Jerry W.
Published: April 2023

PDF File - 49K, Legends for Supplementary Figures and Tables.
Supplementary Figure Legends from Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
Authors: Chittaranjan Suganthi , Bortnik Svetlana , Dragowska Wieslawa H. , Xu Jing , Abeysundara Namal , Leung Amy , Go Nancy E. , DeVorkin Lindsay , Weppler Sherry A. , Gelmon Karen , Yapp Donald T. , Bally Marcel B. , Gorski Sharon M.
Published: April 2023

Supplementary Figure legends
Supplementary Figure 1 from Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
Authors: Chittaranjan Suganthi , Bortnik Svetlana , Dragowska Wieslawa H. , Xu Jing , Abeysundara Namal , Leung Amy , Go Nancy E. , DeVorkin Lindsay , Weppler Sherry A. , Gelmon Karen , Yapp Donald T. , Bally Marcel B. , Gorski Sharon M.
Published: April 2023

Establishment of saturation levels of BAF for MDA-MB-231, R8, SUM159PT and R75.
Supplementary Table 2 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
Authors: Radvanyi Laszlo G. , Bernatchez Chantale , Zhang Minying , Fox Patricia S. , Miller Priscilla , Chacon Jessica , Wu Richard , Lizee Gregory , Mahoney Sandy , Alvarado Gladys , Glass Michelle , Johnson Valen E. , McMannis John D. , Shpall Elizabeth , Prieto Victor , Papadopoulos Nicholas , Kim Kevin , Homsi Jade , Bedikian Agop , Hwu Wen-Jen , Patel Sapna , Ross Merrick I. , Lee Jeffrey E. , Gershenwald Jeffrey E. , Lucci Anthony , Royal Richard , Cormier Janice N. , Davies Michael A. , Mansaray Rahmatu , Fulbright Orenthial J. , Toth Christopher , Ramachandran Renjith , Wardell Seth , Gonzalez Audrey , Hwu Patrick
Published: April 2023

PDF file - 69K, Derivation of the irRC best overall score
Supplementary Methods from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
Authors: Radvanyi Laszlo G. , Bernatchez Chantale , Zhang Minying , Fox Patricia S. , Miller Priscilla , Chacon Jessica , Wu Richard , Lizee Gregory , Mahoney Sandy , Alvarado Gladys , Glass Michelle , Johnson Valen E. , McMannis John D. , Shpall Elizabeth , Prieto Victor , Papadopoulos Nicholas , Kim Kevin , Homsi Jade , Bedikian Agop , Hwu Wen-Jen , Patel Sapna , Ross Merrick I. , Lee Jeffrey E. , Gershenwald Jeffrey E. , Lucci Anthony , Royal Richard , Cormier Janice N. , Davies Michael A. , Mansaray Rahmatu , Fulbright Orenthial J. , Toth Christopher , Ramachandran Renjith , Wardell Seth , Gonzalez Audrey , Hwu Patrick
Published: April 2023

PDF file - 115K
Supplementary Information from Adrenomedullin Blockade Suppresses Growth of Human Hormone–Independent Prostate Tumor Xenograft in Mice
Authors: Berenguer-Daizé Caroline , Boudouresque Françoise , Bastide Cyrille , Tounsi Asma , Benyahia Zohra , Acunzo Julie , Dussault Nadège , Delfino Christine , Baeza Nathalie , Daniel Laurent , Cayol Mylène , Rossi Dominique , El Battari Assou , Bertin Denis , Mabrouk Kamel , Martin Pierre-Marie , Ouafik L'Houcine
Published: April 2023

PDF file 114K, described the legends of all the supplementary figures
Supplementary Methods from Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer
Authors: Shimamura Takeshi , Chen Zhao , Soucheray Margaret , Carretero Julian , Kikuchi Eiki , Tchaicha Jeremy H. , Gao Yandi , Cheng Katherine A. , Cohoon Travis J. , Qi Jun , Akbay Esra , Kimmelman Alec C. , Kung Andrew L. , Bradner James E. , Wong Kwok-Kin
Published: April 2023

Supplementary Methods - PDF file 201K, Supplementary Methods
Figure S2 from Adrenomedullin Blockade Suppresses Growth of Human Hormone–Independent Prostate Tumor Xenograft in Mice
Authors: Berenguer-Daizé Caroline , Boudouresque Françoise , Bastide Cyrille , Tounsi Asma , Benyahia Zohra , Acunzo Julie , Dussault Nadège , Delfino Christine , Baeza Nathalie , Daniel Laurent , Cayol Mylène , Rossi Dominique , El Battari Assou , Bertin Denis , Mabrouk Kamel , Martin Pierre-Marie , Ouafik L'Houcine
Published: April 2023

PDF file 507K, Expression of CLR, RAMP2, and RAMP3 in Du145 cells
Figure S1 from Adrenomedullin Blockade Suppresses Growth of Human Hormone–Independent Prostate Tumor Xenograft in Mice
Authors: Berenguer-Daizé Caroline , Boudouresque Françoise , Bastide Cyrille , Tounsi Asma , Benyahia Zohra , Acunzo Julie , Dussault Nadège , Delfino Christine , Baeza Nathalie , Daniel Laurent , Cayol Mylène , Rossi Dominique , El Battari Assou , Bertin Denis , Mabrouk Kamel , Martin Pierre-Marie , Ouafik L'Houcine
Published: April 2023

PDF file 169K, Characterization of polyclonal anti-AM antibody ({alpha}AM)
Supplementary Figure 4 from TMPRSS2-ERG Status Is Not Prognostic Following Prostate Cancer Radiotherapy: Implications for Fusion Status and DSB Repair
Authors: Dal Pra Alan , Lalonde Emilie , Sykes Jenna , Warde Fiona , Ishkanian Adrian , Meng Alice , Maloff Chad , Srigley John , Joshua Anthony M. , Petrovics Gyorgy , van der Kwast Theodorus , Evans Andrew , Milosevic Michael , Saad Fred , Collins Colin , Squire Jeremy , Lam Wan , Bismar Tarek A. , Boutros Paul C. , Bristow Robert G.
Published: April 2023

Supplementary Figure 4 - PDF file 122K, Univariate Kaplan-Meier plots of biochemical relapse-free survival in a subgroup of patients treated with androgen deprivation therapy (ADT) in the (A) aCGH- and (B) IHC-cohorts
Supplementary Table 1 from Long-Term Survival in Primary Glioblastoma With Versus Without Isocitrate Dehydrogenase Mutations
Authors: Hartmann Christian , Hentschel Bettina , Simon Matthias , Westphal Manfred , Schackert Gabriele , Tonn Jörg C. , Loeffler Markus , Reifenberger Guido , Pietsch Torsten , von Deimling Andreas , Weller Michael
Published: April 2023

Supplementary Table 1 - PDF file 49K, Individual profiles of LTS-36 patients with IDH1/2-mutant glioblastomas
Supplementary Figure 4 from Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs
Authors: Patwardhan Parag P. , Surriga Oliver , Beckman Michael J. , de Stanchina Elisa , Dematteo Ronald P. , Tap William D. , Schwartz Gary K.
Published: April 2023

PDF file - 181KB, Cell cycle analysis of MPNST and ST8814 after 24 hours of drug treatment.
Supplementary Figure 5 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Authors: Chodon Thinle , Comin-Anduix Begoña , Chmielowski Bartosz , Koya Richard C. , Wu Zhongqi , Auerbach Martin , Ng Charles , Avramis Earl , Seja Elizabeth , Villanueva Arturo , McCannel Tara A. , Ishiyama Akira , Czernin Johannes , Radu Caius G. , Wang Xiaoyan , Gjertson David W. , Cochran Alistair J. , Cornetta Kenneth , Wong Deborah J.L. , Kaplan-Lefko Paula , Hamid Omid , Samlowski Wolfram , Cohen Peter A. , Daniels Gregory A. , Mukherji Bijay , Yang Lili , Zack Jerome A. , Kohn Donald B. , Heath James R. , Glaspy John A. , Witte Owen N. , Baltimore David , Economou James S. , Ribas Antoni
Published: April 2023

PDF file - 243KB, Lack of autoreactivity to bone marrow cells in patient F5-10.
Supplementary Figure 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Authors: Zhang Ying , Farenholtz Kaitlyn E. , Yang Yanzhi , Guessous Fadila , diPierro Charles G. , Calvert Valerie S. , Deng Jianghong , Schiff David , Xin Wenjun , Lee Jae K. , Purow Benjamin , Christensen James , Petricoin Emanuel , Abounader Roger
Published: April 2023

PDF file - 296K, Short-time exogenous HGF treatment enhances the in vivo anti-tumor effects of METi
Supplementary Figure 6 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Authors: Stefanska Barbara , Cheishvili David , Suderman Matthew , Arakelian Ani , Huang Jian , Hallett Michael , Han Ze-Guang , Al-Mahtab Mamun , Akbar Sheikh Mohammad Fazle , Khan Wasif Ali , Raqib Rubhana , Tanvir Imrana , Khan Haseeb Ahmed , Rabbani Shafaat A. , Szyf Moshe
Published: April 2023

PDF file - 701KB, Supplementary Figure S6. (A) 1) Expression of the depleted genes, RASAL2 and NENF, quantified by QPCR after first (I) and second (II) transfection of Hep3B HCC cell line with scrambled siRNA (siCtrl) and siRNA directed to RASAL2 (siRASAL2) or NENF (siNENF). 2) Effect on cell growth after first (day 3), second (day 6) and third (day 9) transfection with siRASAL2 or siNENF. 3) Effect on cell invasion as measured by Boyden chamber invasion assay after second transfection with siRASAL2 or siNENF. For Hep3B cells transfected with siRASAL2 or siNENF, evaluation of expression after third transfection was not possible due to the reduced cell number after three transfections. Therefore, invasive assay measurements were performed after second transfection. All results represent mean � S.D. of two or three determinations in either two or three independent experiments - ***P < 0.001, **P < 0.01, *P < 0.05. (B) HepG2 and SkHep1 cells were transfected twice with siCtrl, siRASAL2 or siNENF followed by subcutaneous injection of 2x106 HepG2 and 1x106 SkHep1 cells into the NOD/SCID mice as described in the Materials and Methods. Each group was composed of six male mice 4-6 weeks old. Differences in tumor volume were monitored starting from post-injection week 2 until the mice were sacrificed and are demonstrated in charts. Results represent the mean � SEM for each group of animals - ***P < 0.001, **P < 0.01, *P < 0.05.
Figure-S2 from ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Authors: Huang Hsuan-Ying , Wu Wen-Ren , Wang Yu-Hui , Wang Jun-Wen , Fang Fu-Min , Tsai Jen-Wei , Li Shau-Hsuan , Hung Hsiao-Chin , Yu Shih-Chen , Lan Jui , Shiue Yow-Ling , Hsing Chung-His , Chen Li-Tzong , Li Chien-Feng
Published: April 2023

Figure-S2 PDF file 129K, Figure-S2 ADI-PEG20 treatment in myxofibrosarcoma cell lines and xenografts: (A) Pharmacokinetic curve of ADI-PEG20 demonstrates its dose-dependent capability in deprivation of arginine in culture medium of OH931 cells within the range from 0 to 100 ng/ml. (B) Macroscopic appearances of xenograft specimens treated with PBS versus various doses of ADI-PEG20. After 28 days of treatment, mice are scarified and tumor sizes are measured, demonstrating apparent regressing fibrotic appearance in the ADI-PEG20-treated groups even at a dose as low as 2.5 IU/kg. (C) ADI-PEG20 treatment impairs cell proliferation of myxofibrosarcoma and causes S phase arrest of cell cycle. (a) By using an ELISA-based, colorimetric assay to assess the rate of BrdU uptake, cell proliferation is significantly reduced in OH931 (upper), NMFH-1 (middle), and NMFH-2 (right) cell lines incubated with 150 IU of ADI-PEG20 for 72 h, as compared to the corresponding PBS-treated controls. (b) As analyzed by flow cytometry for OH931 cell line, cell cycle distribution in one each representative experiment is demonstrated for treatment with vehicle alone (upper), 75 IU of ADI-PEG20 (middle), and 150 IU of ADI-PEG20 (lower), showing dose-dependent S phase arrest induced by ADI-PEG20
Supplementary Tables 1 - 4 from Molecular Markers in Key Steroidogenic Pathways, Circulating Steroid Levels, and Prostate Cancer Progression
Authors: Lévesque Éric , Huang Shu-Pin , Audet-Walsh Étienne , Lacombe Louis , Bao Bo-Ying , Fradet Yves , Laverdière Isabelle , Rouleau Mélanie , Huang Chao-Yuan , Yu Chia-Cheng , Caron Patrick , Guillemette Chantal
Published: April 2023

PDF file - 126K, Supplementary Table 1. Genotype frequencies 1 of htSNPs in steroidogenic genes and their association with BCR in Caucasians (n=526). Supplementary Table 2. Association between htSNPs in the steroidogenic pathway and prostate cancer-specific mortality in Asians under ADT (n=601) Supplementary Table 3. Non-significant associations between htSNPs in candidate steroidogenic pathways and prostate cancer-specific mortality in Asians under ADT (n=601) Supplementary Table 4. Non-significant associations between htSNPs in candidate steroidogenic pathways and all cause mortality in Asians under ADT (n=601)
Supplementary Figures 1 - 4 from Growth and Activation of Natural Killer Cells Ex Vivo from Children with Neuroblastoma for Adoptive Cell Therapy
Authors: Liu Yin , Wu Hong-Wei , Sheard Michael A. , Sposto Richard , Somanchi Srinivas S. , Cooper Laurence J.N. , Lee Dean A. , Seeger Robert C.
Published: April 2023

PDF file - 1549K, Supplemental Figure 1. Cytokine and chemokine release from K562 Clone 9.mbIL21 aAPC-expanded effector cells after 24-hour incubation with neuroblastoma cell line CHLA-255-Fluc alone or with anti-GD2 antibody ch14.18. Supplemental Figure 2. Anti-tumor activity of K562 Clone 9.mbIL21 aAPC-expanded and cryopreserved effector cells from a normal donor PBMC that were thawed and cultured for 3 days or thawed and immediately injected intravenously into NOD/SCID mice beginning 7 days after they had received 106 CHLA-255-Fluc neuroblastoma cells intravenously. Supplemental Figure 3. Anti-tumor activity of dose-dense treatment with K562 Clone 9.mbIL21 aAPC-expanded and cryopreserved aNK cells derived from a patient�s PBMC. Supplemental Figure 4. Anti-tumor activity of K562 Clone 9.mbIL21 aAPC-expanded and cryopreserved aNK cells derived from a patient�s PBMC when treatment was begun 21 days (late treatment) after tumor cell injection.