bluuebunny/crossref_metadata_2025 huggingface dataset:
Calligraphy of Images: Artworks by Yukei Teshima
Authors:   Ural State University of Architecture and Art, Filonenko Nadezhda S. ,   Tomsk State University, Tretyakova Maria S. ,   Ural State University of Architecture and Art,   Tomsk State University
Published: May 2022

Postwar Japanese calligraphy has been little studied in Western art history, and in particular, there is no analysis of the work of one of the most important calligraphers of postwar Japan,Yukei Teshima (1901–1987). The relevance of this research lies in the fact that the Calligraphy of Images (Japanese “Shosho”), created by the master, is an example of building a dialogue between fundamentally different traditions of Western and Eastern art, a dialogue that allows the calligrapher to see the uniqueness of Japanese calligraphy, including its spiritual and aesthetic content. The purpose of this study is to determine the specifics of Teshima’s work, using the example of his most famous artworks: “Hokai” (literally “Collapse”) (1957), containing the image of houses collapsing one after another from the explosions of aerial bombs at the end of World War II; and “Tsubame” (“Swallow”) (1960), giving rise to the feeling of flight through a “dancing” movement of a bird. The authors conclude that, although Tesima’s “calligraphic paintings” show a connection simultaneously with the Chinese roots of Japanese calligraphy and the avant-garde painting of the West, the calligrapher remains faithful to the Japanese artistic and aesthetic tradition. Unlike Chinese calligraphy, traditionally understood as a tool for “nurturing life”, or avant-garde painting generated by Western conceptuality, Teshima’s calligraphy expresses the Buddhist ideals of accepting one’s destiny (one’s path to enlightenment) and lack of attachment. The calligrapher uses the “hisshoku” (“rusty brush”) writing technique, which involves “overcoming” the brush and conveying the tactile sensation of a stroke (a symbol of overcoming the materiality of the world), and also forms the “boundless space” of the sheet, i. e. “aki”, which he calls “Space of [divine] love” and connects with the free soaring of the spirit.
Dramatic growth of hydrological science in the UK in the 1960s and early 1970s
Authors: McCulloch Christine
Published: May 2022

The mid-1960s to early 1970s were a formative stage in hydrology in the UK. This was a period of a major increase in government funding for science. Establishing hydrology as an environmental science to compete for a share in this boost in funding with well-recognised subjects such as geology, ecology and oceanography depended on the work of enthusiastic scientists influencing the Natural Environment Research Council (NERC). Progress was made by key individuals not only by their own research contributions but also by their influential work within the government, exemplified by the roles of five physicists. In attempting to accelerate hydrological science, mistakes were made but, in this period, a major research institute was founded, large field catchment experiments were set up and research and training within UK universities increased significantly. The research is based on participant observation and examination of contemporary committee papers held in the UK National Archives, Kew and in the Science Museum Archive, Wroughton.
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective
Authors: Rezaei Nima , Abhari Amir Parsa , Etemadifar Masoud , Yazdanpanah Niloufar
Published: May 2022

N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors, highly important in regulating substantial physiologic processes in the brain and the nervous system, and disturbance in their function could contribute to different pathologies. Overstimulation and hyperactivity of NMDARs, termed glutamate toxicity, could promote cell death and apoptosis. Meanwhile, their blockade could lead to dysfunction of the brain and nervous system. A growing body of evidence has demonstrated the prominent role of NMDARs in demyelinating disorders and anti- NMDAR encephalitis. Herein, we provide an overview of NMDARs’ dysfunction in the physiopathology of demyelinating disorders such as multiple sclerosis and neuromyelitis optica spectrum disorders.
Extracellular Vesicles From Bone Marrow Mesenchymal Stem Cells Inhibit
Apoptosis and Autophagy of Ischemia-hypoxia Cardiomyocyte Line in
vitro by Carrying miR-144-3p to Inhibit ROCK1
Authors: Wang Wenjuan , Peng Xue , Zhao Li , Zhao Hongying , Gu Qianqian
Published: May 2022

Introduction:

Acute myocardial infarction (AMI) has been classified as a prevalent condition threatening human health. This study sought to explore the effects of bone marrow mesenchymal stem cells (BMSCs)-extracellular vesicles (EVs) on cardiomyocyte apoptosis and autophagy induced by ischemia-hypoxia (I/H).

Methods and Materials:

EVs were isolated from BMSCs by means of ultracentrifugation. The I/H cardiomyocyte model was established and cultured with EVs to evaluate the degree of internalization of EVs by the cardiomyocyte line, apoptosis, proliferation, and autophagy of the cardiomyocyte line. The targeting relationship between miR-144-3p and ROCK1 was verified. EVs were isolated after transfection of BMSCs with the miR-144-3p inhibitor to evaluate the effect of miR-144-3p on cardiomyocyte line.

Results and Discussion:

After overexpression of ROCK1 in the I/H cardiomyocyte line treated with EVs, the I/H cardiomyocyte line apoptosis and autophagy were determined. BMSCs-EVs suppressed I/H-induced apoptosis and autophagy of cardiomyocyte line. BMSCs-EVs carried miR-144-3p into the I/H cardiomyocyte line, and the down-regulation of miR-144-3p in EVs partially inverted the suppression of apoptosis and autophagy of the I/H cardiomyocyte line induced by EVs. Our findings denoted that miR-144-3p targeted ROCK1. Overexpression of ROCK1 partially inverted the inhibition of EVs on I/H cardiomyocyte line apoptosis and autophagy. BMSCs-EVs-derived miR-144-3p targeted ROCK1 to radically activate the PI3K/AKT/mTOR pathway. Overall, our study elicited that BMSCs-EVs carried miR-144-3p into the I/H cardiomyocyte line to target ROCK1 and stimulate the PI3K/AKT/mTOR pathway, thus inhibiting I/H-induced cardiomyocyte line apoptosis and autophagy.
Multi-Color States of High Contrast Nano Prussian Yellow Electrochromic
Film
Authors: Baioun Abeer , Kellawi Hassan
Published: May 2022

Aim:

Construction of electrochromic device via Prussian yellow nanofilm on glass electrode.

Background:

Energy conservation is one of the primary research topics nowadays. Electrochromic
devices with low power consumption and short stable switching periods are well suited to energyefficient
applications, e.g., smart windows, car mirrors, displays, and electronic papers.

Objective:

Preparation of electrochromic Prussian yellow nanofilm on ITO glass by a simple chemical
facile method and study of its electrochromic features.

Methods:

Prussian yellow nanofilm (iron (III) hexacyanoferrate (III)), was prepared by immersing the
substrate in a solution of ferric nitrate and Potassium hexacyanoferrate. Prussian yellow nanofilm is
characterized by ultraviolet-visible (Uv-Vis) spectroscopy, cyclic voltammetry and electrochemical
impedance spectroscopy. Prussian yellow nanofilm shows an intense yellow color when it is in a pristine
state.

Results:

Resultant Prussian yellow nanofilm underwent reversible redox reactions accompanied by
color changes from Prussian yellow to Prussian green to further Prussian blue, then to Prussian white.
The transmittance of Prussian yellow nanofilm varies from 21% for colored state at 450nm to 81 %
(for fully bleached) at 0.9V. The contrast ratio and ratio of optical density to charge density were examined
and the coloration efficiency was calculated to be 299.6 cm2C-1.

Conclusion:

Prussian yellow can be very simply prepared and used as an efficient, fast switching electrochromic
device with high color contrast.
Análisis morfométrico de cinco especies del complejo Gracilaria mammillaris (Gracilariaceae, Rhodophyta) en el Atlántico mexicano
Authors: Vilchis Martha Isabel , Dreckmann Kurt M. , Sentíes Abel
Published: May 2022

Antecedentes y Objetivos: El complejo Gracilaria mammillaris es un conjunto de especies de algas rojas cuya identificación resulta complicada debido al reducido número de caracteres morfológicos que las delimitan. Esta problemática se acentúa cuando se encuentran distribuidas en una misma región. El objetivo del presente estudio fue determinar, mediante análisis morfométricos, la existencia de caracteres que permitan la delimitación de cinco especies del complejo Gracilaria mammillaris en el Atlántico mexicano.
Métodos: Veinticuatro caracteres morfométricos de cinco especies del complejo Gracilaria mammillaris fueron sometidos a un análisis de componentes principales para evaluar la existencia de un patrón de variación morfológica. Los componentes resultantes fueron analizados mediante un NP-MANOVA. Se calculó y graficó la media aritmética y los intervalos de confianza para los caracteres con un mayor peso en la discriminación. Se realizó un análisis de agrupamiento UPGMA para sustentar los resultados anteriores. 
Resultados clave: Los análisis mostraron que la única especie del complejo que se segregó fue Gracilaria curtissiae, el resto no mostraron diferencias significativas entre ellas. En promedio, el largo y ancho de las células corticales de la porción media del talo fueron más grandes en G. curtissiae que en las otras; y el largo y ancho de las células medulares en la porción media del talo resultaron ser en promedio más pequeñas en G. curtissiae que en los demás miembros del complejo. El análisis de agrupamiento sustentó los resultados anteriores.   
Conclusión: Un proceso de especiación en curso podría ser la respuesta a que las propiedades morfológicas de cuatro de las cinco especies estudiadas aún no sean distinguibles, pero sí las filogenéticas. Análisis futuros de reloj molecular y filogeográficos permitirán entender mejor el estado de divergencia en el que se encuentran estos taxones.
Evaluation of a Mobile Health App Offering Fertility Information to Male Patients With Cancer: Usability Study
Authors: Gelgoot Eden Noah , Kruglova Katya , Chan Peter , Lo Kirk , Rosberger Zeev , Chown Philippa , Kazdan Jordana , O’Connell Siobhan Bernadette Laura , Zelkowitz Phyllis
Published: May 2022

Background

Cancer and its treatment can adversely affect male fertility. Although sperm banking is an effective fertility preservation method, there is an unmet need for information and support surrounding these issues.

Objective

This usability study evaluates a mobile health app providing male patients with cancer with credible information about the impact of cancer and its treatment on fertility and fertility preservation.

Methods

Participants were recruited by a market research firm. Eligibility criteria were men who were 18-45 years of age, identified as male, diagnosed with new or recurring cancer within 1 year, not in fertility treatment, able to read and write in English or French, and had internet access. App usage was tracked for 2 weeks. After app use, participants provided qualitative feedback about their experiences using the app as well as quantitative data regarding their sperm banking decisions, perceived change in fertility knowledge, evaluation of the app’s information on the Information Assessment Method, and the app’s quality on the user version of the Mobile App Rating Scale.

Results

The sample included 40 men aged 27-45 years. Approximately 68% (27/40) indicated that no one had previously spoken to them about the impact of cancer on fertility, and 85% (34/40) had not received information on fertility preservation. Approximately 83% (33/40) found the app’s information relevant, and 85% (34/40) said that it increased their fertility knowledge. Approximately 23% (9/40) made a decision about sperm banking after using the app. Participants rated the app’s quality highly, with mean scores (out of 5) of 4.14 for information, 4.06 for functionality, 3.84 for aesthetics, and 3.63 for engagement.

Conclusions

The app proved to be useful for male patients with cancer, suggesting that mobile health resources could be beneficial to incorporate into clinical care to enable shared decision-making about fertility.
Evaluation of a Mobile Health App Offering Fertility Information to Male Patients With Cancer: Usability Study (Preprint)
Authors: Gelgoot Eden Noah , Kruglova Katya , Chan Peter , Lo Kirk , Rosberger Zeev , Chown Philippa , Kazdan Jordana , O’Connell Siobhan Bernadette Laura , Zelkowitz Phyllis
Published: May 2022

BACKGROUND

Cancer and its treatment can adversely affect male fertility. Although sperm banking is an effective fertility preservation method, there is an unmet need for information and support surrounding these issues.

OBJECTIVE

This usability study evaluates a mobile health app providing male patients with cancer with credible information about the impact of cancer and its treatment on fertility and fertility preservation.

METHODS

Participants were recruited by a market research firm. Eligibility criteria were men who were 18-45 years of age, identified as male, diagnosed with new or recurring cancer within 1 year, not in fertility treatment, able to read and write in English or French, and had internet access. App usage was tracked for 2 weeks. After app use, participants provided qualitative feedback about their experiences using the app as well as quantitative data regarding their sperm banking decisions, perceived change in fertility knowledge, evaluation of the app’s information on the Information Assessment Method, and the app’s quality on the user version of the Mobile App Rating Scale.

RESULTS

The sample included 40 men aged 27-45 years. Approximately 68% (27/40) indicated that no one had previously spoken to them about the impact of cancer on fertility, and 85% (34/40) had not received information on fertility preservation. Approximately 83% (33/40) found the app’s information relevant, and 85% (34/40) said that it increased their fertility knowledge. Approximately 23% (9/40) made a decision about sperm banking after using the app. Participants rated the app’s quality highly, with mean scores (out of 5) of 4.14 for information, 4.06 for functionality, 3.84 for aesthetics, and 3.63 for engagement.

CONCLUSIONS

The app proved to be useful for male patients with cancer, suggesting that mobile health resources could be beneficial to incorporate into clinical care to enable shared decision-making about fertility.
Does Oxford Government Response Tracker Explain the SARS-CoV-2 Morbidity and Mortality (Preprint)
Authors: Kishore Kamal , Jaswal Vidushi , Pandey Anuj Kumar , Verma Madhur , Koushal Vipin
Published: May 2022

BACKGROUND

The significance of Non-pharmaceutical Interventions by governments across the globe in containing the spread of COVID-19 is well established. The Oxford tracker keeps track of various policy initiatives to mitigate SARS-CoV-2 and release them as Comprehensive Health Index (CHI) and Stringency Index (SI).

OBJECTIVE

This study aims to demonstrate the utility of CHI and SI–innovative measures of Oxford university to gauge and evaluate the government responses for containing the spread of SARS-CoV-2.

METHODS

In this ecological study, we analyzed data from two publicly available data sources: Oxford Covid-19 Government Response Tracker (OxCGRT) and World Health Organization (WHO). The current study used data from March 4, 2020 till October 24, 2021. We applied Auto-Regressive Integrated Moving Average (ARIMA) and Seasonal ARIMA (SARIMA) to model the data. The performance of different models was assessed using a combination of evaluation criteria: Adj-R2, Root Mean Square of Error (RMSE) and Bayesian Information Criteria (BIC).

RESULTS

The strict implementation of policies by the government to contain the crises of SARS-CoV-2 led to a very high value of CHI and SI in the beginning. Although the value of CHI and SI gradually fell over subsequent lockdowns–the same was consistently higher at values of more than 80% points. During the initial investigation, we found that both Cases Per Million (CPM) and Deaths Per Million (DPM) were following the same trend. However, the final CPM and DPM model were SARIMA (3,2,1)(1,0,1) and ARIMA (1,1,1), respectively.

CONCLUSIONS

Digital epidemiology can–and–should be successfully integrated into existing surveillance systems for better disease monitoring, management, and evaluation. The wider adoption to integrate, collect and disseminate epidemiological data digitally will also facilitate individual-specific models rather than population-specific models. Therefore, the policymakers, public health experts, and programmers must come on board to design a hybrid health system that can borrow from the strengths of the existing physical surveillance system and the ever-expanding digital ecosystem.
Key to the Atlantic Gates of the Arctic
Authors: Gordeeva Svetlana , Belonenko Tatyana , Morozova Lidia
Published: May 2022

We consider the decomposition of water temperature fields into the Empirical Orthogonal Functions (EOFs), also known as Principal Components (PCs). We use the GREP data (Global Reanalysis Ensemble Product) in this study and we examine water temperature at the horizon of 457 m for the period 1993–2019 in the area limited to 50°–80°N, 50°W–20°E. It is shown that the first two Principal Components of decomposition (PC1 and PC2) are responsible for 48% of the total variance, and all subsequent ones are smaller by an order of magnitude. The time series of PC1 and PC2 are further considered as indicators responsible for the transfer of Atlantic heat to the Arctic. Transport and heat fluxes have been calculated through the cross-section 64.5°N, which connects Iceland with Scandinavia. It is shown that PC1 characterizes transport through the cross-section, and PC2 is responsible for heat fluxes. The analysis of the spatial distribution of PC1 and PC2 loadings allowed us to introduce three new NAT, NAHT1, and NAHT2 indices determined by water temperature anomalies. The NAT index is responsible for the transport of Atlantic waters to the Arctic, and two identical indices NAT1 and NAT2 characterize the corresponding heat transfer by these waters. The time series responsible for heat transfer to the Arctic [https://doi.org/10.2205/2022ES000792-data] in text format  are available at the website of Earth Science Data Base (ESDB) repository [http://esdb.wdcb.ru/] located in Geophysical Center RAS.
Freezing of Tidal Current Under Ice in a Shallow Channel
Authors: Morozov Eugene , Marchenko A. , Filchuk K.
Published: May 2022

We analyze tidal currents under ice in a shallow channel located near the tip of the Van Mijen Fjord in Spitsbergen. During the flood cycle of tide seawater flows under ice and strongly freezes in a shallow channel. During the ebb cycle salinity of the outflowing water is greater than that of the inflowing water. Salt balance is estimated. During high-water tide, salt water seeps through the cracks in the ice to the surface, which increases salinity of the snow and water mixture.
Role of Coroprotect Kit for Management of Covid 19: A Prophylaxis Case Study Report
Authors: Pandya Shridhar , Savaliya Chetan , Thummar Kamlesh
Published: May 2022

Globally Sars-Cov2 virus but with variety of Mutation like from Gamma to Delta, Delta to Omicron and at present in few country mixed Delta + Omicron cases found. At present pandemic condition needs a prophylaxis treatment against COVID-19. Drugs discoveries from Ayurvedic and phytoconstituents are working on interventions to combat COVID-19 infection. The purpose of the study was to evaluate preventive action (prophylaxis) of proposed intervention in around 500 healthy subjects with negative RT-PCR test, who have been administered with Coroprotect kit to explore the preventive potential of the intervention. Considering evidences from past research on Coroprotect kit together with the incidence of Positive RT-PCR rate in 500 subjects it can be concluded that Coroprotect kit could be a primary option to boost immunity against covid-19 and fight against infection. Surely the phytoconstituents based composition of Coroprotect kit holds promise to patients and healthcare stakeholders as safe and efficacious intervention in Covid 19 as prophylaxis and therapeutic as well.
Detection and Classification of Leukemia Using Deep Learning
Authors: Sadashiv Wagh Kishor , Sanjay Kamthe Siddhesh , Pradeep Sawant Vikrant , Ani Chavan Akash , Janardhan Kakde Anirudha
Published: May 2022

Abstract: The practice of medicine is getting modernized every year and continuously moving towards more automated systems that help and improves the healthcare practice to be more productive with treatments and accurate in their assessments. Leukemia is a form of cancer that can be a fatal disease, and to rehabilitate and treat it requires a correct and early diagnosis. Standard methods have transformed into automated computer tools for analyzing, diagnosing, and predicting symptoms. Advanced methods can be used to help patients detect terminal disorders such as leukemia, which is a fatal disorder and common cancer type amongst children. The methods used for the identification of leukemia subtypes in the suggested framework are Dense Convolutional Neural Network (DenseNet-121) and Residual Convolutional Neural Network (ResNet-34). Because advanced CNN models, such as ResNet and DenseNet, are deeper and more complex having the ability to learn better. Keywords: Leukemia, Deep Learning, Classification, DenseNet, ResNet, CNN
Hydraulic experiment in non-pressure pipeline made of polymer material
Authors: Abdulameer Layth Saeed , Orlov Vladimir A. , Dzhumagulova Nazira T.
Published: May 2022

Introduction. To solve the problem of water shortage for irrigation in the city of Kerbala (Iraq), for the first time, a decision was made to use treated wastewater from urban wastewater treatment plants. Transportation of water from treatment facilities to irrigated lands is carried out through a pipeline in a non-pressure mode. Using the Water Card simulation model, the optimal pipe diameters for two flows, 1200 and 2,200 mm, were selected. The capacity of the existing treatment plant is 1.16 m3/s or 100,000 m3/day, and after the introduction of new treatment facilities, the flow rate will increase to 4.63 m3/s or 400,000 m3/ day. The aim of the work was to experimentally confirm the choice of the optimal diameter of the pipes and determine the hydraulic characteristics of the flow in it. In this regard, in laboratory conditions, experimental studies of the hydraulic characteristics of the flow in a polyethylene pipe with a diameter of 100 mm in the range of slopes (0.005–0.03), with fluid flow in non-pressure, were carried out. Using the theory of hydrodynamic similarity, the results of experimental data were recalculated for pipe diameters of 1200 and 2,200 mm. As field data, when modeling hydrodynamic similarity, the results obtained in the simulation model are taken into account. In world practice, there is experience in the reuse of treated wastewater, but water is supplied to the place of consumption in most cases through open channels. For the first time, pipes of large diameters are used in this work, which requires a more detailed study of the hydraulic parameters of the flow in it.

Materials and methods. Using the theory of hydrodynamic similarity, the results of experimentally obtained hydraulic parameters were calculated for plastic pipes with a diameter of 1200 mm at a water flow rate of 1.16 m3/s and 2,200 mm at a flow rate of 4.63 m3/s.

Results. Conducting experimental studies and recalculating experimental data from a similar model to a full-scale object (the results obtained using the Water Card simulation model are used as a full-scale object) using the Froude method with similarity coefficients made it possible to obtain the following values of average flow rates, hydraulic friction coefficients λ, Chezy coefficients C, Reynolds numbers and other flow characteristics when filling the pipeline from 0.1 to 0.8 for pipes with diameters of 1200 and 2,200 mm.

Conclusions. Conducting laboratory studies to determine the hydraulic characteristics of a polyethylene pipeline with a diameter of 100 mm as a model and substantiate the hydraulic similarity of the model and nature, in the form of plastic pipes with diameters of 1,200 and 2,200 mm, respectively, will allow designing a gravity system of main pipelines for transporting treated wastewater in the city of Karbala (Iraq). Further, the data of the simulation model are used as field data.
THE MOBILITY OF NATSUME SOSEKI TO LONDON AND HIS CULTURAL ADAPTATION IN 'RODONTŌ'
Authors: Firdausy Laily Raff , Susilo Syahrur Marta Dwi
Published: May 2022

The mobility from East to West in nowadays perspective might be very different from that of the old days. This paper discusses the mobility of Natsume Soseki from Japan to London in the early 1900s and the cultural adaptation he does there. This research applied descriptive analysis method and the cultural adaptation theory with a novel entitled Rondontō as the material object. Some studies related to this were use as both references and supporting instruments. The findings showed that the mobility of Soseki to London is indeed affects many things in his life. However, from the cultural adaptation perspective, it appears that Soseki does not adapt well to his new society in the city. Though he accepts his new environment and also communicate well with the host or Londoners, but the acceptance of the host and the pressure to adapt have led him to uncomfortable situation. These factors affect the functional fitness where he is not expecting much from the new environment as well as his psychological health where he feels like not belonging to the place. Despite the uncomfortable situation, the mobility gives him an important experience and affects much to him, especially his works and life as a scholar of English literature.
Suppression of terpenoid synthesis in tomato plants by a begomovirus enhances the attraction of its vector
Authors: Chen Gong , Su Qi , Yuan Gege , Shi Xiaobin , Turlings Ted , Zhang Youjun
Published: May 2022

Vectors of viruses and other plant pathogens are known to often be
attracted by pathogen-infected plants, which promotes pathogen spread.
However, few studies have examined how virus-induced changes in plant
volatiles mediate such preference. Previous research has demonstrated
that tomato plants become more attractive to the whitefly Bemisia
tabaci when they are infected by the begomovirus Tomato yellow
leaf curl virus (TYLCV). In the current study, we found that the
increase in attractiveness is associated with TYLCV-repressed terpenoid
synthesis in the virus-infected plants. The observed TYLCV suppression
of terpenoid synthesis is similar to the suppression of terpenoid
synthesis induced by whitefly infestation. Secondary metabolite analyses
and olfactometer experiments with mutant plants revealed that a reduced
release of terpenoids through TYLCV-induced suppression of flavonoid
synthesis causes B. tabaci females to prefers TYLCV-infected
plants over non-infected plants. These results show that TYLCV infection
triggers the same changes in odor signaling as caused by B.
tabaci infestation, such that both B. tabaci infestation and
TYLCV infection increase whitefly aggregation and thereby increase
vector acquisition and spread of TYLCV.
Advanced Secondary Lung Adenocarcinoma, ALK Mutation, from Treatment of Childhood Osteopetrosis: Case Report
Authors: Moffat Gordon , Davidson Christopher , Gregg Richard
Published: May 2022

A 28-year-old male with a childhood history of osteopetrosis treated
with a stem cell transplantation (SCT) presented with chronic fatigue,
malaise, and abdominal pain. CT imaging identified a left lung nodule
with osseous, hepatic, and splenic metastases, and diffuse
lymphadenopathy. Hepatic biopsy demonstrated metastatic pulmonary
adenocarcinoma, ALK-mutated. He received alectinib with an excellent
radiographic response maintained a year later. Recipients of a SCT have
an increased risk of secondary solid cancer (SSC) and a cumulative
incidence of 10-15% by 15-years. Awareness and screening for SSCs are
essential for an earlier diagnosis and the possibility of improved
outcomes.
Economic feasibility of exploitation of a bioethanol by-product to obtain high-value biopolymers
Authors: Trapé Daiana , Ramos Fernando , Lopez Olivia , Diaz Soledad , Villar Marcelo
Published: May 2022

By-products of bioethanol production, such as vinasse can be transformed
by biotechnological processes into valuable compounds. In this work, the
economic feasibility of producing poly(hydroxyalcanoate)s (PHAs) from
vinasse and diverse microorganisms was studied employing a
superstructure whose objective function is the maximization of the Net
Present Value (NPV). The model was run employing data reported in the
literature about PHAs productivities obtained by using different
bacteria strains and vinasse as carbon source. Thus, comparison of
different scenarios is shown from techno-economic and environmental
aspects. Mathematical model estimated that PHA production cost was 2.27
- 3.02 USD and the investment resulted 9- 13 million dollars. The energy
consumption was also calculated and it was 13.8 - 21 MJ/Kg PHA. The
model returned NPV negative values in those scenarios with low
accumulation and low yield of PHAs, indicating that benefits are not
being obtained and, therefore, would not meet the expectations for an
investment project. Positive NPV values were obtained, being the highest
one 35.09 million dollars. Results evidenced that microorganism
selection, concentration of the pretreated vinasse, and inorganic salts
in the culture media would be the most relevant factors to take into
account when designing a PHA production plant.
Leech-Inspired Shape-Encodable Liquid Metal Robots for Reconfigurable Circuit Welding and Transient Electronics
Authors: Wang Ben , Zhang Baofeng , Tan Yongzhu , Ji Fengtong , Lv Guanghui , Pan Chengfeng , Handschuh‐Wang Stephan , Zhang Li , Zhou Xuechang
Published: May 2022

Deformability and self-adaptability are important for soft robots in
order to deal with uncertain and varying situations and environments
during movement and navigation. Droplet-based robots are great
candidates to travel inside narrow and constrained spaces without
damaging the interfaces due to their extreme deformability and liquid
nature, which enables smooth contact between robots and target spaces.
Here, we propose magnetic liquid metal droplet robots, comprising liquid
metal and carbonyl iron, that can perform reversible telescopic
deformation, bending, and on-demand locomotion. The magnetic liquid
metal-based robots can perform on demand and reversible coalescence and
splitting by intricately applying magnetic fields. Importantly, the
liquid metal robot can perform phase transition to fix the desired shape
after the programmable shape encoding. The liquid metal-based soft
robots can serve as dynamic and recyclable switches for complex
circuits, and are capable of repairing damaged sections of microcircuits
by remote actuation, controllable coalescence, and on-demand circuit
welding. The technology provides a new application scenario of
droplet-based soft robots for on-demand circuit welding and transient
recyclable electronics.

Corresponding author(s) Email:  X.Z.: xczhou@szu.edu.cn; L.Z.:
lizhang@mae.cuhk.edu.hk; B.W.: benwang@szu.edu.cn
Prey adjust courtship signals and anti-predator behaviour to both predation threat and age
Authors: Hubancheva Antoniya , Senderov Viktor , Nowotny Manuela , Schöneich Stefan , Goerlitz Holger
Published: May 2022

Courtship signals may attract predators. Thus, finding a mating partner
and avoiding predation are contradicting tasks with direct fitness
consequences. It is unclear, however, how prey species balance the costs
and benefits of those vital tasks over their lifetime. Here, we
quantified how a prey species with a conspicuous courtship song, the
bush-cricket Tettigonia viridissima, adjusts its singing
behaviour in response to increasing levels of bat predation threat and
how those adjustments change in the course of its lifetime. We show that
young males favour survival over mating by acoustically hiding from
predators for longer time, while old males prioritize mating over
survival. Thus, males of different age trade-off differently the risk of
losing mating opportunities against the risk of falling prey to bats.
Our results highlight the flexibility of vital behaviours and
demonstrate how they are balanced over a lifetime to maximize fitness.
Basolateral amygdala astrocytes modulate of diabetic neuropathic pain and may be a potential therapeutic target for koumine
Authors: Lu Jingshan , Yang Lan , Chen Jian , Xiong Fangfang , Cai Ping , Wang Xinyao , Xiong Bojun , Chen Zehong , Chen Li , Yang Jian , Yu Changxi
Published: May 2022

Background and Purpose: New remedies are required for the treatment of
diabetic neuropathic pain (DNP) due to insufficient efficacy of
available therapies. Here, we used chemogenetic approaches combined with
in vivo pharmacology to elucidate the role of BLA astrocytes in DNP
pathogenesis and provide new insights into DNP therapeutic strategies.
Experimental Approach: A streptozotocin-induced DNP model was
established. Designer receptors exclusively activated by designer drugs
(DREADDs) were used to regulate the activity of astrocytes. Mechanical
hyperalgesia was assessed using the electronic von Frey test.
Anxiety-like behaviors were detected by open field and elevated plus
maze tests. Astrocytic activity was detected by immunofluorescence, and
cytokine content was determined by ELISA. Key Results: BLA astrocytes
were regulated by DREADDs, and inhibition of BLA astrocytes attenuated
mechanical allodynia and anxiety-like behavior in DNP rats.
Contrastively, temporary activation of BLA astrocytes induced allodynia
without anxious behavior in naive rats. In addition, we found that
koumine alleviates mechanical allodynia and anxiety-like behavior in DNP
rats, inhibits the activation of BLA astrocytes and suppresses the
inflammatory response. Furthermore, persistent activation of BLA
astrocytes by chemogenetic mimics chronic pain, and koumine can
alleviate its pain hypersensitivity and anxiety-like behavior.
Conclusion and Implications: DREADDs bidirectionally regulate the
activity of BLA astrocytes, which proves for the first time the role of
BLA astrocytes activation in the pathogenesis of DNP and represents a
novel therapeutic strategy for DNP. Koumine ameliorated DNP, perhaps by
inhibiting the activation of BLA astrocytes and reveal KM as a potential
candidate for treating DNP.
BASES TEÓRICO-FILOSÓFICAS PARA O DESIGN DE EDUCAÇÃO INTERCULTURAL COMO DIÁLOGO DE SABERES
Authors: El-Hani Charbel N.
Published: May 2022

Neste trabalho, são discutidas bases teórico-filosóficas para a construção de uma educação intercultural fundamentada num diálogo de saberes, tanto em termos mais gerais, quanto no domínio específico do ensino de ciências. Estas bases têm sido elaboradas a partir de estudos filosóficos e experiências de pesquisa em comunidades pesqueiras artesanais. Essas experiências incluem, de maneira central, trabalho colaborativo com professoras da educação básica que atuam nessas comunidades, visando ao desenvolvimento de inovações educacionais que se apoiam, em parte, sobre essas bases teórico-filosóficas. Dentre elas, o artigo se debruça principalmente sobre o modo como entendemos a atitude intercultural e a noção de diálogo de saberes, relacionando esta última a uma discussão sobre a natureza, as possibilidades e os limites da tradução intercultural. A formulação dessas bases teórico-filosóficas é parte da etapa de pesquisa preliminar de estudos de design educacional, encontrando-se no momento em processo de transposição para o planejamento e a realização do trabalho pedagógico no contexto da colaboração com as professoras, numa comunidade de prática em constituição. Dado que este é um artigo de caráter teórico, não apresentamos e analisamos dados relacionados ao trabalho colaborativo e às inovações educacionais nas quais ele tem resultado. Tratamos, contudo, de alguns desdobramentos das bases teórico-filosóficas para atividades desenvolvidas na comunidade de prática e no trabalho docente. Enfocamos, em particular, a proposição de princípios de design, conforme entendidos na pesquisa de design educacional, como meio de mobilizar para a construção de práticas pedagógicas as bases teórico-filosóficas discutidas no artigo.
Actions that contribute to science teaching involving argumentation and their relationships with pedagogical content knowledge
Authors: Ibraim Stefannie De Sá , Justi Rosária
Published: May 2022

In argumentation-based science teaching, teachers play an important role and are the main party responsible for the introduction of argumentation in classrooms. In this study, we discuss how actions that contribute to science teaching involving argumentation are expressed by a teacher on leading different types of didactic sequences, and how such actions relate to teachers’ knowledge with regard to argumentation and teachers’ pedagogical content knowledge (PCK). For this reason, we have constructed an instrumental case study, based on the observation of four didactic sequences led by an experienced teacher, and through interviews with her. From their analysis, we conclude that the goals set by the teacher in the didactic sequences have had an influence upon the actions that contribute to science teaching involving argumentation shown by the teacher, suggesting a strong link between the elements of PCK and those of the Knowledge for Teachers’ Actions through Argumentation. As possible consequences, we draw attention to the need to add value to a hybrid method for teaching argumentation, involving implicit and explicit teaching, as well as the proposal of the set of actions that contribute to science teaching involving argumentation. This can contribute towards the investigations into the role of teachers within argumentation-based science teaching, and to teacher education.
CONSTRUINDO CONHECIMENTO SOBRE A BIOLOGIA EVOLUTIVA NO ENSINO MÉDIO: A OPERAÇÃO, A ASSIMILAÇÃO E A INTERAÇÃO LÚDICA EM UM JOGO PEDAGÓGICO
Authors: Moraes Fernando Aparecido de , Soares Márlon Herbert Flora Barbosa
Published: May 2022

Este artigo apresenta alguns dos resultados de uma tese de doutorado surgidos a partir da relação das experiências do pesquisador, enquanto professor, com o que a literatura específica da área de Ensino de Biologia aponta sobre as necessidades do ensino de Evolução Biológica para a Educação Básica. O objetivo deste recorte é dar subsídios teóricos para se pensar em possibilidades de construção de conhecimento de conceitos relativos à Evolução Biológica em sala de aula com base na utilização de uma estratégia pedagógica lúdica, o jogo pedagógico. Inicialmente, o artigo apresenta uma discussão teórica sobre aspectos do ensino de Evolução Biológica na Educação Básica, relacionando esse ensino com a necessidade de inovação no que se refere às estratégias. Depois, a discussão teórica parte para a caracterização do jogo pedagógico relacionando-o com a Epistemologia Genética de Piaget. Após uma breve discussão teórica, são apresentados os procedimentos metodológicos da pesquisa qualitativa, realizada com 21 estudantes voluntários, de duas turmas da 3ª série do Ensino Médio de um Centro de Ensino em Período Integral, localizado no município de Jataí/GO. O recorte da análise em questão, se dá a partir do conteúdo construído durante a aplicação do jogo aos estudantes, registrado por meio da gravação audiovisual e transcrito posteriormente. Com o objetivo de avaliar o jogo, buscando verificar as suas possibilidades de permitir a construção do conhecimento de conceitos evolutivos, são trazidas para a discussão três categorias que emergiram na pré-análise do conteúdo: a operação, a assimilação e a interação lúdica, sendo que, ao longo da análise, os autores apresentam evidências de que em vários momentos da aplicação do jogo aconteceram situações de operação, assimilação e interação lúdica. Nestes momentos, também fica evidenciado que conceitos evolutivos abstratos selecionados para o jogo, como ancestral comum e especiação, foram operados e assimilados de modo coletivo pelos estudantes. Na conclusão do trabalho, com base nos resultados apresentados, os autores refletem sobre a importância do jogo pedagógico, sobretudo, no processo de ensino e aprendizagem de Evolução Biológica na Educação Básica.
The Strategic Importance of Entrepreneurship as a Mechanism for Sustainable Economic Growth in Nigeria
Authors:   1Department of Business Administration Lagos State University of Science and Technology, Ikorodu, Lagos, Nigeria 2Department of Human Resource Management Osun State University, Oshogbo, Osun State, Nigeria 3Department of Office Technology and Management Lagos State University of Science and Technology, Ikorodu, Lagos, Nigeria, Adesanya Abel, Segun (PhD) , Oginni Babalola Oluwayemi (PhD) , Damisola Omolara Adewunmi
Published: May 2022

The focus of this paper is to critically assess the strategic importance of entrepreneurship as a mechanism for sustainable economic growth in Nigeria considering the experiences of developed nations like the America, Europe, Japan, India, and China. Entrepreneurship has been instrumental in economic growth, balanced regional development, and job creation in most dynamic economies, where technology is changing at a faster rate and the product life cycle is becoming less. Research in entrepreneurship development indicates that there is a lack of a theoretical model to examine rural entrepreneurship development particularly in the developing countries like Nigeria. The methodology adopted in this paper is the narrative – textual case study (NTCS); it is a social science research method that relies on the information and data from several sources for problem-solving. It is a fact that entrepreneurship development plays a vital role in economic development of any nation including the developing countries like Nigeria. However, despite this, most entrepreneurial policies and programs seems to favour the urban centres until recently when efforts are geared towards the rural areas. Thus, this paper examines the strategic role of entrepreneurship in the development of the rural areas in a developing economy. The study reveals that the right business environment for entrepreneurship is lacking in Nigeria on account of bad and inadequate infrastructural facilities, political instability, terrorism, multiple taxes, all stand as barriers to entrepreneurship and economic growth. The paper concludes that government should focus on adequate security, improve infrastructural facilities and enabling environment that will lead to economic growth which can be sustained to a developmental level. Keywords: Nigeria, Strategic, Entrepreneurship, Sustainable Development, Economic Growth.
A Formal Verification Model for Security Vulnerability in Non-Fungible Tokens (NFTS) Platform.
Authors:   1Department of Computer Science, University of Port Harcourt, Port Harcourt, Nigeria  2Department of Computer Science, Niger Delta University, Bayelsa State, Nigeria.  E-mails: 1betty_ahubele@uniport.edu.ng, Ahubele B.O. ,   2okolaibiriyai@gmail.com  Phones: 1+2348087473122,   2+2348038996396., Okolai B.D.
Published: May 2022

Non-fungible tokens have been a unique transformation in the implementation of the concept of distributed ledger technology in digital assets. NFTs are said to be non-interchangeable, which distinguishes its value from fungible tokens like Bitcoin (Btc). Scammers are utilizing the open source nature of the blockchain to victimize users and steal their NFTs, leaving NFT collectors with infringed artwork. In a bid to eliminate security vulnerability and attack in NFT platform, we implemented a smart contract verification model. Our verification model is a 2-pronged approach that utilized F*, functional programming language. We presented two tools that translated solidity source code and EVM bytecode to solidity* and EVM* respectively. The EVM decompiler analyzes contracts in which the solidity source codes are unavailable as well as low level properties of contracts. The EVM* and Solidity* tools helped to check the equivalence between a solidity program and the bytecode output from the solidity compiler in order to avoid bugs and preserve verified properties at the source level. In this paper, Etherscan token tracker was used to verify and authenticate NFT token before buying or minting such NFT. Keywords: Non-Fungible Tokens (NFTs), The NFT- marketplace (NFTM), Ethereum
Impact of Childhood Onset Psoriasis on Addictive Behaviours, Socioeconomic and Educational Data in Adulthood
Authors: Mahé Emmanuel , Tubach Florence , Jullien Denis , Tran Diep , Paul Carle , Beylot-Barry Marie , Dupuy Alain , Viguier Manuelle , Richard Marie-Aleth , Sbidian Emilie , Beneton Nathalie , Joly Pascal , Chosidow Olivier , Bachelez Hervé
Published: May 2022

Paediatric psoriasis has been associated with school absenteeism, limitation of physical activities, psychiatric disorders and, in the longer term, with sexual dysfunction and addictions. This raises the hypothesis that childhood onset psoriasis may affect patients’ educational development, and further social and professional outcomes. This study evaluated the relationship between childhood onset psoriasis and patients’ educational and socioeconomic characteristics, and the development of addictions in adulthood. This cross-sectional ancillary study captured patients’ characteristics at baseline in the French PSOBIOTEQ registry. Data in adulthood included: educational (baccalaureate) and socioeconomic (working activity) groups, smoking status (self-reporting of being a current smoker vs past smoker or non-smoker), alcohol consumption (defined as at least 1 glass of alcoholic beverage per day), and living conditions (alone/family/social institutions; child at home). A total of 1,960 patients were included, of whom 26.2% had childhood onset psoriasis. In multivariate analyses, childhood onset psoriasis was associated with smoker status (p = 0.02). No association was observed with educational level, working activity, living conditions, or alcohol consumption. This study provides reassuring data overall with regard to the impact of childhood onset psoriasis on major social outcomes. Evidence for some association with addictive behaviours paves the way for larger prospective studies assessing in depth the social and educational impact of this disease.
Effects of Microabrasion Prior to In-office Bleaching on Hydrogen Peroxide Permeability, Color Change, and Enamel Morphology
Authors: Loguercio AD , Vargas LJC , Favoreto MW , Andrade HF , Borges CP F , Dávila-Sánchez A , Reis A , Mora CP
Published: May 2022

Purpose: This study evaluated hydrogen peroxide (HP) diffusion within the pulp chamber, as well as color change and the surface morphology of teeth subjected to various microabrasion (MA) protocols associated or not with in-office (IO) bleaching. Methods: Forty sound premolars were randomly divided into the following four groups (n=10): no treatment (NC); IO bleaching only; IO immediately after MA (IMA), and IO seven days after MA (7MA). After treatments, the HP concentration (μg/mL) within the pulp chamber was determined using ultraviolet-visible (UV-Vis) spectrophotometry. The color change (ΔE*) was evaluated using the digital spectrophotometer before and 1 week after bleaching. The surface morphology was evaluated by scanning electron microscope (SEM). Data from each test were submitted to one-way ANOVA and Tukey tests (α=0.05). Results: All experimental groups exhibited higher HP concentrations compared to the NC group (p<0.00001). However, higher amounts of HP were observed for the IMA group compared to the IO and 7MA groups (p<0.00001). No significant difference in color change was observed among the groups (p<0.001). Pronounced grooves in enamel were found in the IMA and 7MA groups. However, enamel erosion areas were observed only in the 7MA group. Conclusions: The association between MA and IO bleaching could significantly affect the amount of HP inside the pulp chamber. Therefore, it is highly recommended to wait for 1 week after MA procedures before performing IO bleaching.