bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing Internet Online Procurement Frameworks for Construction Firms
Authors: Deraman Rafikullah , Wang Chen , Yap Jeffrey Boon Hui , Li Heng , Mohd-Rahim Faizul Azli
Published: June 2019

Electronic purchasing or e-procurement saves millions of dollars yearly in transaction costs. E-procurement helps to cut down the supplier base, promotes paperless transactions, and increases transparency and accountability in the procurement process. Nonetheless, studies report that around 80% of e-procurement initiatives have met with failure and failed to achieve the desired results. Although studies to better understand the Critical Success Factors (CSFs) of e-procurement implementation involving various industries have been on the rise, little is known about architecture engineering and construction (AEC) practices, which has led to limited development of pragmatic frameworks to uncover the factors. Thus, this study aims to identify those CSFs (predicting variables) which significantly contribute to e-procurement implementation success in the construction sector and to put forward for better implementation. Results from multiple regression analysis revealed five factors to be statistically significant predictors of success. Three factors were determined to be predictors of user satisfaction. Finally, internet online procurement frameworks were developed for the success of e-procurement implementation in the construction sector.
Negative Impact of Social Network Services Based on Stressor-Stress-Outcome: The Role of Experience of Privacy Violations
Authors: Kim Sanghyun , Park Hyunsun , Choi Moon Jong
Published: June 2019

Social network service (SNS) information has benefited many individuals. However, as such information has increased exponentially, the number of SNS users has increased dramatically and negative effects of SNSs on users have emerged. Many SNS users experience negative psychological conditions such as fatigue, burnout, and stress. Thus, in this study, we investigated the SNS and user characteristics that affect SNS fatigue, living disorder, and reduced SNS use intention. We developed a research model to examine the impact of two SNS characteristics (irrelevant information overload and open reachability) and two user characteristics (engagement and maintaining self-reputation) on SNS fatigue. We also examined the role of the experience of privacy violations in the relationship between living disorder and reduced SNS use intention. We collected data from 579 SNS users and created a partial least squares structural equation model to test the hypotheses. The results of the analysis showed that three factors, other than open reachability, positively affected SNS fatigue. Furthermore, we found that SNS fatigue significantly affected living disorder and reduced SNS use intention, and that experience of privacy violations significantly affected the relationship between living disorder and reduced SNS use intention. These results expand our understanding of SNS fatigue and users’ negative behaviors.
Data Anonymization for Hiding Personal Tendency in Set-Valued Database Publication
Authors: Gunawan Dedi , Mambo Masahiro
Published: June 2019

Set-valued database publication has been increasing its importance recently due to its benefit for various applications such as marketing analysis and advertising. However, publishing a raw set-valued database may cause individual privacy breach such as the leakage of sensitive information like personal tendencies when data recipients perform data analysis. Even though imposing data anonymization methods such as suppression-based methods and random data swapping methods to such a database can successfully hide personal tendency, it induces item loss from records and causes significant distortion in record structure that degrades database utility. To avoid the problems, we proposed a method based on swapping technique where an individual’s items in a record are swapped to items of the other record. Our swapping technique is distinct from existing one called random data swapping which yields much structure distortion. Even though the technique results in inaccuracy at a record level, it can preserve every single item in a database from loss. Thus, data recipients may obtain all the item information in an anonymized database. In addition, by carefully selecting a pair of records for item swapping, we can avoid excessive record structure distortion that leads to alter database content immensely. More importantly, such a strategy allows one to successfully hide personal tendency without sacrificing a lot of database utility.
Satellite DNA at the Centromere Is Dispensable for Segregation Fidelity
Authors: Roberti Annalisa , Bensi Mirella , Mazzagatti Alice , Piras Francesca M. , Nergadze Solomon G. , Giulotto Elena , Raimondi Elena
Published: June 2019

The typical vertebrate centromeres contain long stretches of highly repeated DNA sequences (satellite DNA). We previously demonstrated that the karyotypes of the species belonging to the genus Equus are characterized by the presence of satellite-free and satellite-based centromeres and represent a unique biological model for the study of centromere organization and behavior. Using horse primary fibroblasts cultured in vitro, we compared the segregation fidelity of chromosome 11, whose centromere is satellite-free, with that of chromosome 13, which has similar size and a centromere containing long stretches of satellite DNA. The mitotic stability of the two chromosomes was compared under normal conditions and under mitotic stress induced by the spindle inhibitor, nocodazole. Two independent molecular-cytogenetic approaches were used—the interphase aneuploidy analysis and the cytokinesis-block micronucleus assay. Both assays were coupled to fluorescence in situ hybridization with chromosome specific probes in order to identify chromosome 11 and chromosome 13, respectively. In addition, we tested if the lack of centromeric satellite DNA affected chromatid cohesion under normal and stress conditions. We demonstrated that, in our system, the segregation fidelity of a chromosome is not influenced by the presence of long stretches of tandem repeats at its centromere. To our knowledge, the present study is the first analysis of the mitotic behavior of a natural satellite-free centromere.
Chemostratigraphy of the Upper Jurassic (Oxfordian) Smackover Formation for Little Cedar Creek and Brooklyn Fields, Alabama
Authors: Yarbrough Lance D. , Engle Rian A. , Easson Greg
Published: June 2019

The Upper Jurassic (Oxfordian Age) Smackover Formation is a significant source for hydrocarbon production in southwest Alabama. Brooklyn Field is in southeast Conecuh County, Alabama, and has been a major producer of oil and natural gas for the state. The Smackover is a carbonate formation that has been divided into seven distinct lithofacies in the Brooklyn and Little Cedar Creek fields. In southwest Alabama, the facies distribution in the Smackover Formation was influenced by paleotopography of the underlying Paleozoic rocks of the Appalachian system. The goal of this study is to determine elemental ratios in rock core within the Smackover Formation using an X-ray fluorescence (XRF) handheld scanner and to correlate these elemental characteristics to the lithofacies of the Smackover Formation in the Brooklyn and Little Cedar Creek fields. Eight wells were used for the study within Brooklyn Field and Little Cedar Creek fields. Cores from the eight wells were scanned at six-inch intervals. Chemical logs were produced to show elemental weights in relation to depth and lithofacies. The chemical signatures within producing zones were correlated to reservoir lithofacies and porosity. Aluminum, silicon, calcium, titanium, and iron were the most significant (>95% confidence level) predictors of porosity and may be related to the depositional environment and subsequent diageneses of the producing facies. The XRF data suggests relative enrichments in iron, titanium, and potassium. These elements may be related to deposition in relatively restricted marine waters.
Chemical Compositional Signatures of Constituent Minerals of Iron Slags and Ores from the Khmer Monuments
Authors: Uchida Etsuo , Murasugi Motoki , Kuroda Ayaka , Lu Yusu
Published: June 2019

Iron slags and ores were collected from 22 sites (A to V) in Preah Khan of Kompong Svay, the area surrounding Phnom Daek, and the Angkor monuments. Iron ores were taken from two outcrops in Phnom Daek. The chemical compositions of fayalite and wüstite in the iron slags and magnetite in the iron ores were determined using a scanning electron microscope equipped with an energy dispersive spectrometer. Cluster analysis and principal component analysis using averaged chemical compositional data for fayalite allowed for the investigated slag dumps to be classified into two main groups: Groups 1 and 2. The slag dumps in the area surrounding Phnom Daek and those in the Angkor monuments were classified as Group 1, and those in Preah Khan of Kompong Svay were classified as Group 2, except for sites C and U, which were classified as Group 1. Radiocarbon dating was carried out on 10 charcoal fragments from slag dumps outside the Angkor area. The dating results indicate that iron making in Preah Khan of Kompong Svay was conducted in and after the 13th century except for sites C and U, where iron ores may have been supplied from Phnom Daek before the 13th century.
Optimization and Application of Bioflocculant Passivated Copper Nanoparticles in the Wastewater Treatment
Authors: Dlamini Nkosinathi Goodman , Basson Albertus Kotze , Pullabhotla Viswanadha Srirama Rajasekhar
Published: June 2019

Nanotechnology offers a great opportunity for efficient removal of pollutants and pathogenic microorganisms in water. Copper nanoparticles were synthesized using a polysaccharide bioflocculant and its flocculation, removal efficiency, and antimicrobial properties were evaluated. The synthesized nanoparticles were characterized using thermogravimetry, UV-Visible spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), powder X-ray diffraction, scanning electron microscope (SEM), and transmission electron microscope (TEM). The highest flocculation activity (FA) was achieved with the lowest concentration of copper nanoparticles (0.2 mg/mL) with 96% (FA) and the least flocculation activity was 80% at 1 mg/mL. The copper nanoparticles (CuNPs) work well without the addition of the cation as the flocculation activity was 96% and worked best at weak acidic, neutral, and alkaline pH with the optimal FA of 96% at pH 7. Furthermore, the nanoparticles were found to be thermostable with 91% FA at 100 °C. The synthesized copper nanoparticles are also high in removal efficiency of staining dyes, such as safranin (92%), carbol fuchsine (94%), malachite green (97%), and methylene blue (85%). The high removal efficiency of nutrients such as phosphate and total nitrogen in both domestic wastewater and Mzingazi river water was observed. In comparison to ciprofloxacin, CuNPs revealed some remarkable properties as they are able to kill both the Gram-positive and Gram-negative microorganisms.
Spatial Keyword Query of Region-Of-Interest Based on the Distributed Representation of Point-Of-Interest
Authors: Zhu Xiangdian , Wu Ye , Chen Luo , Jing Ning
Published: June 2019

The tremendous advance in information technology has promoted the rapid development of location-based services (LBSs), which play an indispensable role in people’s daily lives. Compared with a traditional LBS based on Point-Of-Interest (POI), which is an isolated location point, an increasing number of demands have concentrated on Region-Of-Interest (ROI) exploration, i.e., geographic regions that contain many POIs and express rich environmental information. The intention behind the POI is to search the geographical regions related to the user’s requirements, which contain some spatial objects, such as POIs and have certain environmental characteristics. In order to achieve effective ROI exploration, we propose an ROI top-k keyword query method that considers the environmental information of the regions. Specifically, the Word2Vec model has been introduced to achieve the distributed representation of POIs and capture their environmental semantics, which are then leveraged to describe the environmental characteristic information of the candidate ROI. Given a keyword query, different query patterns are designed to measure the similarities between the query keyword and the candidate ROIs to find the k candidate ROIs that are most relevant to the query. In the verification step, an evaluation criterion has been developed to test the effectiveness of the distributed representations of POIs. Finally, after generating the POI vectors in high quality, we validated the performance of the proposed ROI top-k query on a large-scale real-life dataset where the experimental results demonstrated the effectiveness of our proposals.
Melanopsin+RGCs Are fully Resistant to NMDA-Induced Excitotoxicity
Authors: Vidal-Villegas Beatriz , Di Pierdomenico Johnny , Miralles de Imperial-Ollero Juan A , Ortín-Martínez Arturo , Nadal-Nicolás Francisco M , Bernal-Garro Jose M , Cuenca Navarro Nicolás , Villegas-Pérez María P , Vidal-Sanz Manuel
Published: June 2019

We studied short- and long-term effects of intravitreal injection of N-methyl-d-aspartate (NMDA) on melanopsin-containing (m+) and non-melanopsin-containing (Brn3a+) retinal ganglion cells (RGCs). In adult SD-rats, the left eye received a single intravitreal injection of 5µL of 100nM NMDA. At 3 and 15 months, retinal thickness was measured in vivo using Spectral Domain-Optical Coherence Tomography (SD-OCT). Ex vivo analyses were done at 3, 7, or 14 days or 15 months after damage. Whole-mounted retinas were immunolabelled for brain-specific homeobox/POU domain protein 3A (Brn3a) and melanopsin (m), the total number of Brn3a+RGCs and m+RGCs were quantified, and their topography represented. In control retinas, the mean total numbers of Brn3a+RGCs and m+RGCs were 78,903 ± 3572 and 2358 ± 144 (mean ± SD; n = 10), respectively. In the NMDA injected retinas, Brn3a+RGCs numbers diminished to 49%, 28%, 24%, and 19%, at 3, 7, 14 days, and 15 months, respectively. There was no further loss between 7 days and 15 months. The number of immunoidentified m+RGCs decreased significantly at 3 days, recovered between 3 and 7 days, and were back to normal thereafter. OCT measurements revealed a significant thinning of the left retinas at 3 and 15 months. Intravitreal injections of NMDA induced within a week a rapid loss of 72% of Brn3a+RGCs, a transient downregulation of melanopsin expression (but not m+RGC death), and a thinning of the inner retinal layers.
Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
Authors: Huang Shar-yin Naomi , Pommier Yves
Published: June 2019

Mammalian mitochondria contain four topoisomerases encoded in the nuclear genome: TOP1MT, TOP2α, TOP2β, and TOP3α. They also contain the two known tyrosyl-DNA phosphodiesterases (TDPs): TDP1 and TDP2, including a specific TDP2S isoform. Both TDP1 and TDP2 excise abortive topoisomerase cleavage complexes (TOPccs), yet their molecular structures and mechanisms are different. TDP1 is present across eukaryotes, from yeasts to humans and belongs to the phospholipase D family. It functions without a metal cofactor and has a broad activity range, as it also serves to cleanse blocking 3′-DNA ends bearing phosphoglycolate, deoxyribose phosphate, nucleoside, nucleoside analogs (zidovudine), abasic moieties, and with a lower efficiency, TOP2ccs. Found in higher vertebrates, TDP2 is absent in yeast where TDP1 appears to perform its functions. TDP2 belongs to the exonuclease/endonuclease/phosphodiesterase family and requires magnesium as a cofactor to excise TOP2ccs, and it also excises TOP1ccs, albeit with a lower efficiency. Here, we review TDP1 and TDP2 in the context of mitochondrial DNA repair and discuss potential new research areas centered on the mitochondrial TDPs.
The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
Authors: Maiuolo Jessica , Gliozzi Micaela , Musolino Vincenzo , Carresi Cristina , Nucera Saverio , Macrì Roberta , Scicchitano Miriam , Bosco Francesca , Scarano Federica , Ruga Stefano , Zito Maria Caterina , Oppedisano Francesca , Mollace Rocco , Paone Sara , Palma Ernesto , Muscoli Carolina , Mollace Vincenzo
Published: June 2019

The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the different compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the presence, of specific stressor stimuli can be damaged causing the onset of neurodegenerative processes. An essential component of BNB is represented by the endothelial cells surrounding the sub-structures of peripheral nerves and increasing evidence suggests that endothelial dysfunction can be considered a leading cause of the nerve degeneration. The purpose of this review is to highlight the main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve.
Conceptualizing Company Response to Community Protest: Principles to Achieve a Social License to Operate
Authors: Vanclay Frank , Hanna Philippe
Published: June 2019

To gain a social license to operate and grow, companies should have effective community engagement activities, social impact assessment processes, environmental and social impact management procedures, and human rights-compatible grievance redress mechanisms in place. In this way, environmental impacts and social impacts would likely be identified and addressed before issues escalate and social risk amplifies. Companies also need to treat communities with respect and be mindful of local culture. Where these things are not done, there will be no social license to operate. Protests are mechanisms by which affected communities express their concerns and signal there is no social license. As argued in our previous work on conceptualizing social protests, protests are warning signs, as well as opportunities for companies to improve. Rather than let protest actions escalate, leading to violent confrontation and considerable cost and harm, companies should engage in meaningful dialogue with protesters. Unfortunately, company response is often inadequate or inappropriate. In this paper, we identify around 175 actions companies might take in relation to community protest, and we discuss how these actions variously have the potential to escalate or de-escalate conflict, depending on whether the company engages in appropriate and genuine interaction with protesters or if repressive measures are used. While effective engagement will likely de-escalate conflict, ignoring or repressing protests tends to provoke stronger reactions from groups seeking to have their concerns heard. When companies address community concerns early, their social license to operate is enhanced. We also outline the primary international standards companies are expected to comply with, and we identify the key environmental, social, and governance issues (ESG principles) that should be respected.
Tribology and Dentistry: A Commentary
Authors: Lanza Antonio , Ruggiero Alessandro , Sbordone Ludovico
Published: June 2019

Since 1966 the term “tribology” has integrated different topics like friction, lubrication and wear. After a few years, interest in this type of phenomena rapidly spread out around the world of biology and medicine, determining a new research area defined as biotribology. This commentary is conceived within this framework with the aim of underlining the close link between tribology and dentistry regarding both physiological and restorative issues. The contact between teeth requires investigation into their tribological behavior focusing on the enamel wear process against natural teeth and/or artificial teeth, allowing us to obtain useful information on the tribological behavior of restorative materials. Thus, tested materials may be natural teeth, restorative materials (metal alloys, ceramics, composites) or both. This work aims to make a contribution to underlining the need for greater standardization of tribological experimental procedures as well as to obtaining more homogeneous and indicative results on the tested tribo systems.
Metal Sulphides and Their Carbon Supported Composites as Platinum-Free Counter Electrodes in Dye-Sensitized Solar Cells: A Review
Authors: Meyer Edson , Bede Asanda , Zingwe Nyengerai , Taziwa Raymond
Published: June 2019

Energy sufficiency is a critical requirement for the economic prosperity of modern countries. Efficient harnessing of solar energy using technologies such as the dye-sensitized solar cell could solve the energy problem which persistently plagues developing countries. Despite having a simple operational procedure and modest power conversion efficiency of 13.8%, the dye-sensitized solar cell consists of an expensive platinum counter electrode which makes commercial success futile. Thus, this review intends to establish the progress researchers have attained in the development of sulphide based counter electrodes as alternatives to platinum, thereby lowering cost of production. Metallic sulphides are good electrocatalysts and cheap, hence, they possess the necessary requirements for effective functional counter electrodes. Furthermore, ternary metallic sulphides are known to exhibit higher efficiencies stemming from the synergistic effect produced by the co-existence of two metal ions in a crystal structure, which is believed to induce greater catalytic capability. Incorporation of metallic sulphides with carbon materials, which are exceptional electrical conductors, could potentially produce more efficient counter electrodes. In that regard, this review seeks to establish the effect recently developed composite counter electrodes comprising metallic sulphides and carbon-based materials have induced on the functionality of the counter electrode (CE).
Structural and Material Optimization for Automatic Synthesis of Spine-Segment Mechanisms for Humanoid Robots with Custom Stiffness Profiles
Authors: Ciszkiewicz Adam , Milewski Grzegorz
Published: June 2019

Typical artificial joints for humanoid robots use actual human body joints only as an inspiration. The load responses of these structures rarely match those of the corresponding joints, which is important when applying the robots in environments tailored to humans. In this study, we proposed a novel, automated method for designing substitutes for a human intervertebral joint. The substitutes were considered as two platforms, connected by a set of flexible links. Their structural and material parameters were obtained through optimization with a structured Genetic Algorithm, based on the reference angular stiffnesses. The proposed approach was tested in three numerical scenarios. In the first test, a mechanism with angular stiffnesses corresponded to the actual L4–L5 intervertebral joint. Scenarios 2 and 3 featured mechanisms with geometry and structure comparable to the joint, but with custom stiffness profiles. The obtained results proved the effectiveness of the proposed method. It could be employed in the design of artificial joints for humanoid robots and orthotic structures for the human spine. As the approach is general, it could also be extended to different body joints.
Evaluation of Mechanical Properties of a Hollow Endodontic Post by Three Point Test and SEM Analysis: A Pilot Study
Authors: Lo Giudice Giuseppe , Ferrari Cagidiaco Edoardo , Lo Giudice Roberto , Puleio Francesco , Nicita Fabiana , Calapaj Massimo
Published: June 2019

The aim of this study was to investigate the mechanical properties of a fiber hollow endodontic post characterized by the presence of an empty central cylindrical channel extended along the whole length. This particular shape allows clinicians to use the post also as a cementation resin carrier. Ten hollow posts were divided in two groups: the control group (unfilled hollow posts) (Group 0) and hollow posts filled with dual resin cement (Group 1). The samples of both groups were subjected to mechanical and micromorphological analysis by performing a three-point test and SEM observations. In the three-point test, the Group 1 samples exhibited a fracture load of 57.09 ± 5.06 N, a flexural strength of 1323.53 ± 110.09 MPa, and a Young’s modulus of 42.87 ± 0.86 GPa. The samples of Group 2 exhibited a fracture load of 38.17 ± 1.7 N, a flexural strength of 908.87 ± 30.98 MPa, and a Young’s modulus of 40.33 ± 1.9 GPa. The difference between fracture load, flexural strength, and deflection between the two groups was statistically highly significant (p < 0.01). Further, the difference between the Young’s modulus of the two groups was statistically significant (p < 0.05). The values obtained are similar to those of other posts available on the market.
Structural Flexibility in Activated Carbon Materials Prepared under Harsh Activation Conditions
Authors: Gomes Ferreira de Paula Fabiano , Campello-Gómez Ignacio , Ortega Paulo Fernando Ribeiro , Rodríguez-Reinoso Francisco , Martínez-Escandell Manuel , Silvestre-Albero Joaquín
Published: June 2019

Although traditionally high-surface area carbon materials have been considered as rigid structures with a disordered three dimensional (3D) network of graphite microdomains associated with a limited electrical conductivity (highly depending on the porous structure and surface chemistry), here we show for the first time that this is not the case for activated carbon materials prepared using harsh activation conditions (e.g., KOH activation). In these specific samples a clear structural re-orientation can be observed upon adsorption of different organic molecules, the structural changes giving rise to important changes in the electrical resistivity of the material. Whereas short chain hydrocarbons and their derivatives give rise to an increased resistivity, the contrary occurs for longer-chain hydrocarbons and/or alcohols. The high sensitivity of these high-surface area carbon materials towards these organic molecules opens the gate towards their application for sensing devices.
Benefits of a Pre-Treatment Comprehensive Geriatric Assessment in a Rare Case of Gemella Haemolysans Endocarditis in an 86-Year-Old Patient and a Review of the Literature
Authors: Sadaune Lucie , Roca Frédéric , Bordage Mathilde , Le Guillou Vincent , Lesourd Anais , Michel Anne
Published: June 2019

Infective endocarditis is a serious condition, which is associated with high mortality in elderly patients. Gemella haemolysans (GH) is a microorganism from the Streptococcus family, rarely involved in infective endocarditis. Here, we present a case of Gemella haemolysans endocarditis in an 86-year-old patient, successfully treated by antibiotics and surgery following a pre-treatment comprehensive geriatric assessment (CGA). This case is discussed in the context of a review of all published cases of Gemella haemolysans endocarditis. We illustrate the benefit of a systematic pre-treatment comprehensive geriatric assessment in elderly patients with infective endocarditis.
Cleavage Stage versus Blastocyst Stage Embryo Transfer in Oocyte Donation Cycles
Authors: Kontopoulos George , Simopoulou Mara , Zervomanolakis Ioannis , Prokopakis Thomas , Dimitropoulos Kostas , Dedoulis Evaggelos , Grigorakis Stylianos , Agapitou Kristi , Nikitos Eros , Rapani Anna , Vlahos Nikos
Published: June 2019

Background and Objective: During the last few years, a trend has been noted towards embryos being transferred at the blastocyst stage, which has been associated with improved rates regarding implantation and clinical pregnancy in comparison to cleavage stage embryo transfers. There is a limited number of studies investigating this notion in oocyte donation cycles employing cryopreserved embryos. The aim of this study is to evaluate the implantation potential and clinical pregnancy rates between the day 3 cleavage stage and blastocyst stage embryo transfers in oocyte donation cycles employing vitrified embryos. Methods: This is a retrospective evaluation of oocyte donation frozen–thawed transfers completed in our clinic from January 2017 to December 2017. Intracytoplasmic sperm injection was conducted for all oocytes. Following fertilization, all embryos were cryopreserved either at the cleavage or blastocyst stage. Embryo transfer of two embryos was performed under direct sonographic guidance in all cases. Results: Our results confirmed a 55.6% clinical pregnancy (CP) resulting from day 3 embryo transfers, a 68.8% CP from day 5, and 71.4% CP from day 6. Significantly improved pregnancy rates were related to embryo transfers at the blastocyst stage when compared to cleavage stage transfers (68.9% and 55.6% respectively, p = 0.016). The risk with regards to multiple pregnancies was similar. Conclusion: Our findings indicate that in oocyte donation cycles employing vitrified embryos, embryo transfer at the blastocyst stage is accompanied with a significant improvement in pregnancy rates and merits further investigation.
Single Drive Multi-Axis Gyroscope with High Dynamic Range, High Linearity and Wide Bandwidth
Authors: Iqbal Faisal , Din Hussamud , Lee Byeungleul
Published: June 2019

This paper presents the design, fabrication, and characterization of a highly sensitive, single drive multi-axis gyroscope. The multi-axis gyroscope allows for a wide bandwidth in all three axes (X, Y, Z) and exhibits high linearity. The fabricated multi-axis gyroscope was fabricated with a structural thickness of 30 µm and packaged at 100 mtorr using wafer level packaging. The fabricated multi-axis gyroscope has a small footprint of 1426 × 1426 µm2, making it one of the smallest multi-axis gyroscopes. A custom printed circuit board (PCB) was designed for the evaluation of the multi-axis gyroscope. The experimental results demonstrate that the gyroscope has a high sensitivity of 12.56   μ V / dps ,   17.13   μ V / dps and 25.79   μ V / dps in the roll (X-sense), pitch (Y-sense) and yaw (Z-sense) modes respectively. The scale-factor non-linearity of the gyroscope is less than 0.2 % for roll and pitch mode and 0.001 % for the yaw mode, in the full-scale range of ± 1500   deg / s . The multi-axis gyroscope demonstrates an angle random walk of 2.79   dps / Hz , 2.14   dps / Hz , and   1.42   dps / Hz , for the roll, pitch and yaw rate with the in-run bias stability 1.62   deg / s , 1.14   deg / s and 0.84   deg / s respectively.
Fine-Grained Power Gating Using an MRAM-CMOS Non-Volatile Flip-Flop
Authors: Park Jaeyoung , Yim Young
Published: June 2019

An area-efficient non-volatile flip flop (NVFF) is proposed. Two minimum-sized Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) and two magnetic tunnel junction (MTJ) devices are added on top of a conventional D flip-flop for temporary storage during the power-down. An area overhead of the temporary storage is minimized by reusing a part of the D flip-flop and an energy overhead is reduced by a current-reuse technique. In addition, two optimization strategies of the use of the proposed NVFF are proposed: (1) A module-based placement in a design phase for minimizing the area overhead; and (2) a dynamic write pulse modulation at runtime for reducing the energy overhead. We evaluated the proposed NVFF circuit using a compact MTJ model targeting an implementation in a 10 nm technology node. Results indicate that area overhead is 6.9 % normalized to the conventional flip flop. Compared to the best previously known NVFFs, the proposed circuit succeeded in reducing the area by 4.1 × and the energy by 1.5 × . The proposed placement strategy of the NVFF shows an improvement of nearly a factor of 2–18 in terms of area and energy, and the pulse duration modulation provides a further energy reduction depending on fault tolerance of programs.
Analogue Meets Digital: History and Present IT Augmentation of Europe’s Largest Landscape Relief Model in Villach, Austria
Authors: Buchroithner Manfred F.
Published: June 2019

Brought to completion in 1913 after a production time of 24 years, the landscape relief model of Carinthia (Kärnten), on display in Villach, Austria, is, at 182 m², the largest of its kind in Europe. It is painted with nature-like land-cover information and presents the whole federal state of Carinthia and its surroundings including Austria’s highest peak, Großglockner, at a scale of 1:10,000. From 2016 to 2018, a series of computer-generated and partly computer-animated educational contents for rental tablets as well as for projection onto the terrain model and above it have been produced. Their topics are briefly presented. The described Relief von Kärnten is also a paramount example and master copy of how to improve the attractivity of historical physical landscape relief models by means of state-of-the-art information technology. The article is, furthermore, meant to raise awareness for a piece of “geo-art”, which is worth being known at an international scale by both experts and laymen.
Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study
Authors: Panizza Chloe E. , Lim Unhee , Yonemori Kim M. , Cassel Kevin D. , Wilkens Lynne R. , Harvie Michelle N. , Maskarinec Gertraud , Delp Edward J. , Lampe Johanna W. , Shepherd John A. , Le Marchand Loïc , Boushey Carol J.
Published: June 2019

Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot study to demonstrate feasibility and explore efficacy of following IER+MED for 12 weeks to reduce VAT among East Asians in Hawaii. Sixty volunteers (aged 35–55, BMI 25–40 kg/m2, VAT ≥ 90 cm2 for men and ≥ 80 cm2 for women) were randomized to IER+MED (two consecutive days with 70% energy restriction and 5 days euenergetic MED) or an active comparator (euenergetic Dietary Approaches to Stop Hypertension (DASH) diet). Participants and clinic staff (except dietitians) were blinded to group assignments. IER+MED had significantly larger reductions in DXA-measured VAT and total fat mass (−22.6 ± 3.6 cm2 and −3.3 ± 0.4 kg, respectively) vs. DASH (−10.7 ± 3.5 cm2 and −1.6 ± 0.4 kg) (p = 0.02 and p = 0.005). However, after adjusting for total fat mass, change in VAT was not statistically different between groups; whereas, improvement in alanine transaminase remained significantly greater for IER+MED vs. DASH (−16.2 ± 3.8 U/L vs. −4.0 ± 3.6 U/L, respectively, p = 0.02). Attrition rate was 10%, and participants adhered well to study prescriptions with no reported major adverse effect. Results demonstrate IER+MED is acceptable, lowers visceral and total adiposity among East Asian Americans, and may improve liver function more effectively than a healthful diet pattern. ClinicalTrials.gov Identifier: NCT03639350.
Drink Choice is Important: Beverages Make a Substantial Contribution to Energy, Sugar, Calcium and Vitamin C Intake among Australians
Authors: Riley Malcolm D. , Hendrie Gilly A. , Baird Danielle L.
Published: June 2019

It is important to understand the role of beverages in population dietary intake in order to give relevant advice. Population estimates were derived from one-day food recall dietary data from 12,153 participants in the 2011–2012 Australian National Nutrition and Physical Activity Survey. Almost all Australians (99.9%) consumed at least one beverage on the day of the survey, accounting for 16.6% of the total energy intake for adults (aged 19 years and over) and 13.0% for children (aged 2–18 years). Similarly, beverages contributed 26–29% to calcium intake, 22–28% to vitamin C intake, and 35–36% to sugar intake. Water was consumed on the day of the survey by 84.1% of Australian adults and 90.5% of children. For adults, the greatest beverage contributors to total energy intake were alcoholic drinks (5.6%), coffee (3.1%), and soft drinks (1.9%), and for children, plain milk (3.1%), flavoured milk (2.8%), and fruit juice (2.6%). Coffee (10.6%) made the greatest contribution to calcium intake for adults; and plain milk (9.9%) and flavoured milk (7.6%) for children. The greatest contributors to vitamin C intake were fruit juice (13.4%) and alcoholic drinks (6.1%) for adults; and fruit juice (23.4%) for children. For total sugar intake, soft drinks (8.0%), coffee (8.4%), and fruit juice (5.9%) made the highest contribution for adults; and fruit juice (9.8%) and soft drinks (8.7%) for children. The type and amount of beverage consumption has considerable relevance to dietary quality for Australians.
Host-Pathogen Interactions of Mycoplasma mycoides in Caprine and Bovine Precision-Cut Lung Slices (PCLS) Models
Authors: Weldearegay Yenehiwot , Müller Sandy , Hänske Jana , Schulze Anja , Kostka Aline , Rüger Nancy , Hewicker-Trautwein Marion , Brehm Ralph , Valentin-Weigand Peter , Kammerer Robert , Jores Joerg , Meens Jochen
Published: June 2019

Respiratory infections caused by mycoplasma species in ruminants lead to considerable economic losses. Two important ruminant pathogens are Mycoplasma mycoides subsp. Mycoides (Mmm), the aetiological agent of contagious bovine pleuropneumonia and Mycoplasma mycoides subsp. capri (Mmc), which causes pneumonia, mastitis, arthritis, keratitis, and septicemia in goats. We established precision cut lung slices (PCLS) infection model for Mmm and Mmc to study host-pathogen interactions. We monitored infection over time using immunohistological analysis and electron microscopy. Moreover, infection burden was monitored by plating and quantitative real-time PCR. Results were compared with lungs from experimentally infected goats and cattle. Lungs from healthy goats and cattle were also included as controls. PCLS remained viable for up to two weeks. Both subspecies adhered to ciliated cells. However, the titer of Mmm in caprine PCLS decreased over time, indicating species specificity of Mmm. Mmc showed higher tropism to sub-bronchiolar tissue in caprine PCLS, which increased in a time-dependent manner. Moreover, Mmc was abundantly observed on pulmonary endothelial cells, indicating partially, how it causes systemic disease. Tissue destruction upon prolonged infection of slices was comparable to the in vivo samples. Therefore, PCLS represents a novel ex vivo model to study host-pathogen interaction in livestock mycoplasma.
Therapeutic Potential of Kappa Opioid Agonists
Authors: Beck Tyler C. , Hapstack Matthew A. , Beck Kyle R. , Dix Thomas A.
Published: June 2019

Many original research articles have been published that describe findings and outline areas for the development of kappa-opioid agonists (KOAs) as novel drugs; however, a single review article that summarizes the broad potential for KOAs in drug development does not exist. It is well-established that KOAs demonstrate efficacy in pain attenuation; however, KOAs also have proven to be beneficial in treating a variety of novel but often overlapping conditions including cardiovascular disease, pruritus, nausea, inflammatory diseases, spinal anesthesia, stroke, hypoxic pulmonary hypertension, multiple sclerosis, addiction, and post-traumatic cartilage degeneration. This article summarizes key findings of KOAs and discusses the untapped therapeutic potential of KOAs in the treatment of many human diseases.
Development, Testing and Results of a Patient Medication Experience Documentation Tool for Use in Comprehensive Medication Management Services
Authors: Redmond Stephanie , Paterson Nicole , Shoemaker-Hunt Sarah J. , Ramalho-de-Oliveira Djenane
Published: June 2019

The medication experience is an individual’s subjective experience of taking a medication in daily life and can be at the root of drug therapy problems. It is recommended that the patient-centered approach to comprehensive medication management (CMM) starts with an understanding of the patient’s medication experience. This study aims to develop a medication experience documentation tool for use in CMM services, and to understand the usefulness and challenges of using the tool in practice. The tool was developed based on previous research on patients’ medication experiences. It was tested in two rounds by ten CMM pharmacists utilizing the tool as they provided care to patients. Focus groups were conducted to revise the tool after each round and to understand pharmacists’ experiences. The tool was tested for 15 weeks in 407 patient encounters. There was at least one medication experience documented in the electronic medical record 62% of the time. Pharmacists found the tool helpful in raising awareness of the medication experience and motivational interviewing strategies, planning for follow-up visits, as a teaching tool, and making pharmacists realize the fluidity of the medication experience. The tool offered pharmacists a better way to recognize and address medication experiences affecting medication taking behaviors.
Carbon Nanotube versus Graphene Nanoribbon: Impact of Nanofiller Geometry on Electromagnetic Interference Shielding of Polyvinylidene Fluoride Nanocomposites
Authors: Arjmand Mohammad , Sadeghi Soheil , Otero Navas Ivonne , Zamani Keteklahijani Yalda , Dordanihaghighi Sara , Sundararaj Uttandaraman
Published: June 2019

The similar molecular structure but different geometries of the carbon nanotube (CNT) and graphene nanoribbon (GNR) create a genuine opportunity to assess the impact of nanofiller geometry (tube vs. ribbon) on the electromagnetic interference (EMI) shielding of polymer nanocomposites. In this regard, GNR and its parent CNT were melt mixed with a polyvinylidene fluoride (PVDF) matrix using a miniature melt mixer at various nanofiller loadings, i.e., 0.3, 0.5, 1.0 and 2.0 wt%, and then compression molded. Molecular simulations showed that CNT would have a better interaction with the PVDF matrix in any configuration. Rheological results validated that CNTs feature a far stronger network (mechanical interlocking) than GNRs. Despite lower powder conductivity and a comparable dispersion state, it was interestingly observed that CNT nanocomposites indicated a highly superior electrical conductivity and EMI shielding at higher nanofiller loadings. For instance, at 2.0 wt%, CNT/PVDF nanocomposites showed an electrical conductivity of 0.77 S·m−1 and an EMI shielding effectiveness of 11.60 dB, which are eight orders of magnitude and twofold higher than their GNR counterparts, respectively. This observation was attributed to their superior conductive network formation and the interlocking ability of the tubular nanostructure to the ribbon-like nanostructure, verified by molecular simulations and rheological assays.
Piezoelectric Response in Hybrid Micropillar Arrays of Poly(Vinylidene Fluoride) and Reduced Graphene Oxide
Authors: Pariy Igor O. , Ivanova Anna A. , Shvartsman Vladimir V. , Lupascu Doru C. , Sukhorukov Gleb B. , Ludwig Tim , Bartasyte Ausrine , Mathur Sanjay , Surmeneva Maria A. , Surmenev Roman A.
Published: June 2019

This study was dedicated to the investigation of poly(vinylidene fluoride) (PVDF) micropillar arrays obtained by soft lithography followed by phase inversion at a low temperature. Reduced graphene oxide (rGO) was incorporated into the PVDF as a nucleating filler. The piezoelectric properties of the PVDF-rGO composite micropillars were explored via piezo-response force microscopy (PFM). Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) showed that α, β, and γ phases co-existed in all studied samples, with a predominance of the γ phase. The piezoresponse force microscopy (PFM) data provided the local piezoelectric response of the PVDF micropillars, which exhibited a temperature-induced downward dipole orientation in the pristine PVDF micropillars. The addition of rGO into the PVDF matrix resulted in a change in the preferred polarization direction, and the piezo-response phase angle changed from −120° to 20°–40°. The pristine PVDF and PVDF loaded with 0.1 wt % of rGO after low-temperature quenching were found to possess a piezoelectric response of 86 and 87 pm/V respectively, which are significantly higher than the |d33eff| in the case of imprinted PVDF 64 pm/V. Thus, the addition of rGO significantly affected the domain orientation (polarization) while quenching increased the piezoelectric response.
Microbial Degradation of Synthetic Biopolymers Waste
Authors: Siracusa Valentina
Published: June 2019

Over the last ten years, the demand of biodegradable polymers has grown at an annual rate of 20–30%. However, the market share is about less than 0.1% of the total plastic production due to their lower performances, higher price and limited legislative attention in respect to the standard materials. The biodegradability as a functional added property is often not completely perceived from the final consumers. However, the opportunity to use renewable resources and to reduce the dependency from petroleum resources could become an incentive to accelerate their future growth. Renewable raw materials, coming from industrial wastes such as oilseed crops, starch from cereals and potatoes, cellulose from straw and wood, etc., can be converted into chemical intermediates and polymers, in order to substitute fossil fuel feedstock. The introduction of these new products could represent a significant contribution to sustainable development. However, the use of renewable resources and the production of the bioplastics are no longer a guarantee for a minimal environmental impact. The production process as well as their technical performances and their ultimate disposal has to be carefully considered. Bioplastics are generally biodegradable, but the diffusion of the composting technology is a prerequisite for their development. Efforts are required at industry level in order to develop less expensive and high performance products, with minimal environmental impact technologies.
Preparation of Zirconia Nanofibers by Electrospinning and Calcination with Zirconium Acetylacetonate as Precursor
Authors: Rodaev Vyacheslav V. , Razlivalova Svetlana S. , Zhigachev Andrey O. , Vasyukov Vladimir M. , Golovin Yuri I.
Published: June 2019

For the first time, zirconia nanofibers with an average diameter of about 75 nm have been fabricated by calcination of electrospun zirconium acetylacetonate/polyacrylonitrile fibers in the range of 500–1100 °C. Composite and ceramic filaments have been characterized by scanning electron microscopy, thermogravimetric analysis, nitrogen adsorption analysis, energy-dispersive X-ray spectroscopy, and X-ray diffractometry. The stages of the transition of zirconium acetylacetonate to zirconia have been revealed. It has been found out that a rise in calcination temperature from 500 to 1100 °C induces transformation of mesoporous tetragonal zirconia nanofibers with a high specific surface area (102.3 m2/g) to non-porous monoclinic zirconia nanofibers of almost the same diameter with a low value of specific surface area (8.3 m2/g). The tetragonal zirconia nanofibers with high specific surface area prepared at 500 °C can be considered, for instance, as promising supports for heterogeneous catalysts, enhancing their activity.
Psych—An Open Access Journal
Authors: Pesta Bryan
Published: June 2019

It is my great pleasure, on behalf of the editorial board and myself, to introduce Psych, MDPI’s new multidisciplinary, open-access journal for the social and behavioral sciences [...]