bluuebunny/crossref_metadata_2025 huggingface dataset:
Aerobic exercise combined with environmental enrichment improves spatial memory and enhances neuroligin 1 expression: an animal study
Authors: Djawas Faizah Abdullah , Redjeki Sri , Kodariah Ria , Kartinah Neng Tine
Published: October 2019

BACKGROUND Numerous studies have revealed that aerobic exercise (AE) or environmental enrichment (EE) exert positive effects on the molecular, cellular, and structural changes responsible for functional plasticity. Therefore, this study was aimed to investigate whether the combination of AE and EE yields a greater effect on spatial memory and increases the expression of the adhesion molecule neuroligin 1 compared with either of the therapies alone. METHODS Twenty 6-month-old male Wistar rats were randomly divided into four groups: (1) the control group (C), (2) the AE group, (3) the EE group, and (4) the AE-EE group. Escape latency in a Water-E-maze (WEM) task was used as a parameter to assess spatial memory function. Neuroligin 1 protein expression was examined via the immunohistochemistry (IHC) technique followed by IHC optical density (OD) score analysis of the CA1 hippocampal region. RESULTS Data acquired from the WEM task show that escape latency progressively decreased over time in all groups. However, animals in the AE-EE group required less time to complete the task compared with those in the control, AE, and EE groups. IHC OD scores revealed that the combination of AE and EE caused the highest expression of neuroligin 1 in the CA1 hippocampal region among the therapies studied. Statistical analysis indicated significant differences in OD score between the AE-EE and control, AE, and EE groups (p ≤ 0.001). CONCLUSIONS The combination of AE and EE rats increased neuroligin 1 expression and improved the spatial memory of male Wistar rats compared with application of either therapy alone.
A case of nonalcoholic Wernicke’s encephalopathy due to an extreme diet based on magnetic resonance imaging features
Authors: July Julius , Adeline  , Tjandrawidjaja Girianto , Siahaan Yusak Mangara Tua , Widysanto Allen , Horiyanto Hori , Muljadi Rusli
Published: October 2019

Wernicke’s encephalopathy is a rare occurrence in Indonesia because alcohol consumption is very low. However, in Indonesia, Wernicke’s encephalopathy could be triggered by an inadequate intake of thiamine (vitamin B1) due to an extreme diet for several months. It is a case of a 31-year-old male, who presented to the emergency room with a decreased level of consciousness. According to the family, for the last few weeks, he has become less responsive and less attentive. Fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) revealed a unique picture with symmetrical lesions in the bilateral medial thalamus, mammillary bodies, periaqueductal gray matter, and the dorsal surface of the medulla oblongata. Clinically, there is no neck stiffness and no fever. The laboratory results from the blood and cerebrospinal fluid have ruled out meningitis. Treatment with thiamine 200 mg t.i.d. has shown an excellent response and significant clinical improvement. The earlier thiamine substitution treatment is started, the better the outcome because thiamine will prevent further injury to the brain and enhance recovery.
Intravitreal anti-vascular endothelial growth factor injection combined with panretinal photocoagulation for neovascular glaucoma in Indonesian patients with diabetes mellitus: a prospective study
Authors: Artini Widya , Gracia Ajeng , Kekalih Aria , Oktariana Virna Dwi , Victor Andi Arus , Bani Anna Puspitasari
Published: October 2019

BACKGROUND The aim of this study was to determine the levels of vascular endothelial growth factor (VEGF) in the aqueous humor and the effect of intravitreal anti-VEGF injection combined with panretinal photocoagulation (PRP) on the management in diabetes mellitus (DM) patients with neovascular glaucoma (NVG). 

METHODS This study was a prospective, interventional study in DM patients with NVG. Paracentesis followed by intravitreal bevacizumab (IVB) injection was performed in all eyes. The concentration of VEGF obtained from paracentesis was measured. In week-1, the intraocular pressure (IOP), sectorial iris neovascularization (NVI), and visual acuity were documented, and management was continued with PRP laser over a period of 1 week. All parameters and additional interventions performed after PRP were also recorded. 

RESULTS A total of 18 eyes from 17 patients were studied. The mean (SD) level of VEGF in the aqueous humor was 3,864 (1,468) pg/ml, and the mean (SD) of initial IOP was 39 (10.2) mmHg. There was a significant reduction in IOP in week-1 after the first intervention to 24.4 (8.0) mmHg (p = 0.001); however, at 2 weeks the IOP increased to 30.4 (6.7) mmHg. NVI showed significant regression in week-1 after IVB combined with PRP laser (p < 0.05). All eyes required additional glaucoma implants (14 eyes) and cyclocryotheraphy (4 eyes). 

CONCLUSIONS In the eyes of diabetes patients with NVG, VEGF levels were high. With the use of IVB, the IOP was reduced, and NVI regressed; however, due to the severe stages of disease, all eyes required glaucoma surgery.
Cranberries for women with recurrent urinary tract infection: a meta-analysis
Authors: Tambunan Made Parulian , Rahardjo Harrina Erlianti
Published: October 2019

BACKGROUND Cranberries are the most widely used nonantibiotic prophylaxis for recurrent urinary tract infection (rUTI) in women; however, their efficacy still remains uncertain. Hence, this meta-analysis was aimed to assess the effectiveness, safety, and adherence of cranberry as a prophylactic drug for treating rUTI.

METHODS Literature search was conducted using PubMed, EBSCO, Science Direct, Scopus, Cochrane, and Google Scholar. Studies were screened for duplication, inclusion and exclusion criteria, and then reviewed by two authors independently. This included all randomized controlled trials of cranberry derivatives versus placebo and antibiotic prophylaxis. Cochrane risk-of-bias assessment tools were used to evaluate the quality of the study. Quantitative analysis was performed using the Review Manager 5.0 software.

RESULTS Nine studies were included. Among 1,542 participants, cranberry consumption reduced incidence of rUTI in women compared with placebo (p = 0.02). The subgroup analysis revealed that only cranberry capsules were superior to placebo (relative risk [RR] = 0.67, 95% confidence interval [CI] = 0.45–0.98), but not for cranberry juice (RR = 0.85, 95% CI: 0.7–1.04). Antibiotics had better outcome than cranberry for rUTI (RR = 0.83, 95% CI = 0.70–0.98). Most of the participants experienced minor adverse events such as rash and gastrointestinal symptoms. There was also a good adherence rate, ranging from 90.3–99% monthly dose.

CONCLUSIONS Cranberry, especially cranberry capsule consumption, had a significant effect in reducing the incidence of rUTI compared with placebo, with good adherence rates, and minor adverse events. In contrast, although antibiotic use had a greater efficacy, it was associated with a higher risk of severe adverse events.
Different roads to empathy: stage actors and judges as polar cases
Authors: Bergman Blix Stina
Published: October 2019

Using judges and stage actors as instructive polar types this article elucidates factors that influence the inclination to empathise. Both come in close contact with dramatic life stories on an everyday basis but approach empathy from contrasting vantage points: emotional distance versus emotional engagement. Similarities between these polar types can thus disentangle some of the factors that influence professional empathic perspective taking in more general terms. It is argued that reality or fiction in itself does not promote empathy, but the presence of a complete narrative structure which allows for personal recognition of shared attributes or experiences. In both professions the decoupling of emotions from private connotations, individual responsibility for interpretations on stage or in verdicts and defamiliarisation of private experiences can promote empathic perspective taking whereas it is prevented by one-sided perspective taking; for example, by judicial encoding (judges) or getting stuck in private experiences (stage actors). Organisational obstacles to empathy include hierarchal work structures or a ‘teflon culture’.
Immune response evaluation in Balb/c mice after crude extract of Anisakis typica sensitization
Authors: Haryadi Linda , Suprayitno Eddy , Aulanni'am Aulanni'am , Hariati Anik Martinah
Published: October 2019

Background and Aim: Anisakis is a global challenge for a fish product which may lead to a decrease in economic value and consumers' preference. Skipjack (Katsuwonus pelamis) in Kupang, Nusa Tenggara Timur, Indonesia, have important economic value for local fisheries. Anisakis typica is one of the Anisakis species which potent to induce an allergic reaction. However, the study about A. typica involved in the dendritic cells (DCs), T helper 1 (Th1), T helper 2 (Th2), and regulatory T cells (Tregs) is still limited. This study aimed to analyze the dynamic changed of the immune system including DCs, CD4+ T cells, and Tregs after 1 week of A. typica sensitization.

Materials and Methods: Twenty-four male Balb/C mice were randomly divided into four groups (n=6), mice treated with crude A. typica extract (CAE) 50, 75, and 100 mg/kg BW, respectively. CAE was given orally per day for a week. At the end of the experiment, the animals were sacrificed and the spleen was collected. DCs were labeled as CD11c+ interleukin-6+ (IL-6+); CD4+ T cells were distinguished as Th1 (CD4+ interferon-γ+ [IFN-γ+]) and Th2 (CD4+ IL-4+ and CD4+ IL-5+); Tregs were labeled as CD4+CD25+CD62L+. The expression of each cell was determined by flow cytometry.

Results: Our result described that CAE elicits CD11c+ IL-6+, CD4+ IFN-γ+, CD4+ IL-4+, and CD4+ IL-5+ and reduces CD4+CD25+CD62L+ significantly (p<0.05) in dose-dependent manner in mice after A. typica infection.

Conclusion: The Th1/Th2 ratio after A. typica crude extract treatment exhibits a mixed pattern rather than the classical model allergy to food antigens. Our study is expected as a basic understanding of the changes in immune response after A. typica infection.
Neurophysiological effects of corticotropin-releasing factor in the undergoing sections of the olfactory area of the rat cerebral cortex
Authors: Mokrushin A. A. , Shalyapina V. G.
Published: October 2019

Application of corticotrophin-releasing factor (CPF) in concen­trations of 10-9-10-8 M on the rat olfactory cortex slices induced activation of the pre- and postsynaptic excitatory components of the focal potentials recorded in the slices. The amplitude and du­ration of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic and N-methyl-D-aspartate components of postsynaptic evoking potentials increased upon exposure to CRF, while the amplitude of GABAB-mediated inhibitory postsynaptic potentials was sup­pressed. At higher concentrations of CRF (10-8 M) epileptiform charges were recorded in the cells. CRF effects were reversible and eliminated after washing. A long (90 min) exposure induced the phenomena similar to long-term posttetanic potentiation. The findings suggest that CRF has pronounced activating properties and ajfects the glutamatergic and GABAergic systems.
Complete elimination of iodine deficiency-induced diseases in the Republic of Serbia through overall salt iodination
Authors: Simic M. , Banisevic M. , Andjelkovic Z. , Zivic G. , Zikic L. , Beloglav D. , Simic D. , Gerasimov G. A. , Mishchenko B.
Published: October 2019

The territory of Serbia has been long known to be an iodine de­ficiency area. The surveys conducted in the past 50 years have shown that iodine deficiency disorders ranged from small goiters to endemic cretinism. The iodine deficiency control program has been implemented in Serbia since 1951, in so doing, the salt con­centration of iodine (as potassium iodide) has been gradually in­creased and at present it is 20 mg/kg. Just in the mid- 1960s, io­dine prophylaxis led to cessation of new cases of cretinism and large goiters.This survey was undertaken to determine the iodine provision in Serbia. The survey was conducted in accordance with the WHO, UNICEF, and ICCIDD guidelines and it covered 4598 school­children aged 7 to 15 years from the urban and rural areas of 44 municipalities of Central Serbia and Vojvodina. Among all the examinees, the detection rate of the enlarged thyroid was 2.35% (as evidenced by ultrasound study) and the median urinary io­dine concentration was 158 μg/l. The findings suggest that iodine deficiency has been completely eliminated in Serbia due to the ef­fective program of the overall dietary salt iodination.
Role of iodine supply in neonatal adaptation of the thyroid system
Authors: Kasatkina E. P. , Shilin D. Ye. , Petrova L. M. , Khatamova Kh. A. , Lokteva Ye. N. , Samarcheva T. I. , Akinshin V. I.
Published: October 2019

Population frequency of neonatal hyperthyrotropinemia (NHT) in an iodine deficient region was studied with consideration for published reports about the relationship between prenatal iodine supply and fetal and neonatal thyroid function, and the efficiency of iodine prevention of this condition was evaluated by the results of overall screening of newborns for hypothyrosis. The concentrations of thyrotropic hormone (TTH) in whole blood specimens dried on paper were measured in 29588 newborns in the Belgorod region (Russia) in 1995-1998 using the Neonatal hTSH FEIA (Labsystems OY, Finland). Slight iodine deficiency in this region (median iodine excretion with urine 69 mcg/liter, n = 1313) was associated with an extremely high incidence of NHT: more than 5 iU/liter in 47% and more than 20 iU/liter in 7% newborns. Overall prevention with iodinated table salt during 1 year notably decreased the incidence of NHT (by 1.6 times, p < 0.001) and alleviated its severity from severe to mild degree. Preventive treatment of pregnant women by potassium iodide (200 mcg/day) during the same period more effectively decreased the incidence of the pathological parameter (five fold, p < 0.001). A lower incidence of NHT resultant from prenatal iodine treatment was associated with a lowering of the mean TTH level solely at the expense of the newborns with high levels of the hormone; if TTH levels were normal, they did not change. Therefore, thyroid dysfunction in newborns (NHT) indicates iodine deficiency in a region during intrauterine development; this abnormality can be prevented by iodine treatment in microdoses meeting the physiological requirement in iodine, which is increased during gestation. At the beginning of overall prevention of goiter by iodinated table salt, group prevention with potassium iodide is justified in risk groups, primarily in pregnant women; compensation of prenatal deficiency decreases the cost of screening for congenital hypothyrosis due to a lower requirement in TTH retesting.
Effect of chorionic gonadotropin on the regulation of the functional activity of antigen-specific T-suppressors
Authors: Shirshev S. V.
Published: October 2019

Effects of chorionic gonadotropin (CG) on the functional activity of antigen-specific T-suppressors generated in CBA mice on day 14 by supraoptimal dose of thymus-dependent antigen were studied. The activity of T-suppressors was assessed by the level of antibody-producing (ABP) cells forming in the organism of suppressor cell recipients immunized with the same antigen. CG was injected to intact and oophorectomized recipient mice or was directly incubated in a one-hour cell culture with antigenspecific suppressor cells which were then transplanted to intact female mice. CG in a dose of 40 or 200 IU did not influence the capacity of T-suppressors to suppress primary immune response in intact females. In oophorectomized animals the hormone statistically reliably decreased the activity of T-suppressors, no matter what its dose were, and depressed the splenocyte activity. In a cell culture CG similarly depressed T-suppressor functional activity without influencing their homing.
Segregation analysis of diffuse toxic goiter
Authors: Kalinin А. Р. , Sidorova О. Р. , Kamynina Т. S.
Published: October 2019

The authors discuss segregation analysis of diffuse toxic goiter based on 34 histories selected for the proband. In 11 families one of the parents and the child were ill, in 23 the proband’s parents were healthy. Weinberg’s method of solitary registration was used. No correspondence of the monogenic model of disease inheritance was observed for families with the hypothesized autosomal dominant and autosomal recessive types of inheriting.
Autoimmune thyroid diseases: state of the art
Authors: Dedov I. I. , Troshia Ye. A. , Antonova S. S. , Alexandrova G. F. , Zilov A. V.
Published: October 2019

The article devoted to the autoimmune thyroid diseases: state of the art
Combined oral sugar-reducing drug glibomet in therapy of patients with type 2 diabetes mellitus
Authors: Antsiferov M. B. , Maiorov A. Yu.
Published: October 2019

The article devoted to the combined oral sugar-reducing drug glibomet in therapy of patients with type 2 diabetes mellitus
Physiological doses of iodine and carriage of antibodies
thyroid peroxidase: an open, randomized trial
Authors: Fadeev V. V. , Mel'nichenko G. A.
Published: October 2019

This prospective open randomized study explored the effects of the physiological doses of iodine on the structure and function of the thyroid in persons who were carriers of thyroid peroxidase antibodies (TPOAb). The study included 44 females with normal thyroid function and levels of TPOAb of more than 100 mU/l. By employing open block randomization using a random number tables, the patients were divided into 2 groups: 1) 22 females who received potassium iodide in a daily dose of 100 pg for 6 months (a study group) and 2) 22 patients who did not take any therapy or placebo throughout the study (a control group). Three patients (they all from the study group) were excluded from the study due to their incompliance. Following 6 months, two patients were diagnosed as having primary hypothyroidism : 1 patient from the study group had subclinical hypothyroidism with an increase in the level of TSH up to 7.2 mU/l; the other patient from the control group had obvious hypothyroidism (TSH, 67 mU/l). Evaluation of the time course of changes in the level of TSH and the volume of the thyroid revealed no difference between the study and control groups throughout and by the end of the study. A statistically significant decrease in the volume of the thyroid was found in a group of patients with the initially enlarged thyroid treated with potassium iodide. It is concluded that the physiological doses of iodine do not produce any substantial effect on the function and volume of the thyroid in ATOAb carriers.
Pheochromocytoma in children
Authors: Bel'tsevich D. G. , Kuznetsov N. S. , Lysenko M. A.
Published: October 2019

The results of an examination, treatment, and postoperative follow-up of 520 patients with pheochromocytomas who were operated on at the Endocrinology Research Center, Russian Academy of Medical Sciences, in 1957 to 2002 have been analyzed. The patients’ mean age was 39.3±9.2 years; 50 (9.6%) patients aged less than 16 years. There were 213 (41.0%) males in the total group and 32 (62.0%) in the pediatric group. Bilateral adrenal lesion was detected in 68 (13.1%), including 16 (32%) of the 50 children aged less than 16 years. Extraadrenal tumors were ascertained in 36 (6.9%). The concomitance of pheochromocytoma with hereditary syndromes was observed in 36 (6.9%) cases. Two hundred and sixty patients were followed up for 4 to 25 years (mean 8.4+1.9). Recurrence ofpheochromocytoma was revealed in 49 (18.8%) patients; the genuine recurrence (a tumor at the site of primary surgery or metastasis) was found in 16 (6.15%) patients. The genuine recurrence of pheochromocytoma was seen in 6 (12.0%) of the 50 children; its main cause was organ-preserving surgery for multicenter adrenal lesion.
State-wide implementation of edTPA in preparation for high-stakes testing: A mixed-methods study of the concerns of edTPA coordinators
Authors: Many Joyce E. , Bhatnagar Ruchi , Tanguay Carla , Favors-Welch Shaneeka , Thomas Clarice , Cannon Susan Ophelia , Ogletree Tamra , Kim Jihye , Howrey Shannon , An Sohyun , Kurz Karen , Wilson Judi
Published: October 2019

This study examined the implementation of high-stakes adoption of edTPA® in one state in the year prior to consequential use of edTPA scores for teacher licensure. Using a mixed methods design, we investigated concerns of coordinators who were responsible for edTPA implementation in their institutions. We utilized the Concerns Based Adoption Model (CBAM) to understand edTPA coordinators’ Stages of Concern, the nature of the challenges they faced, and the professional development opportunities that alleviated their concerns. Based on the CBAM survey, the most common Stage of Concernfor edTPA coordinators was Management.Coordinators’ interviews revealed the nature of their concerns at different stages and how the size of their institution and supportive resources at particular times may have played a crucial role in shaping the edTPA roll-out in their institutions. The use of the CBAM framework enabled edTPA coordinators (a) to understand their own concerns about the high-stakes policy, (b) to articulate the complexities involved in implementing edTPA initiatives, and (c) to underscore the importance of relating concerns to appropriate professional development opportunities and support for themselves as well as their faculty.
Challenges of Digital Twin System
Authors: Monsone Cristina Rosaria , Jósvai János
Published: October 2019

Today’s manufacturing and assembly systems have to be flexible to adapt quickly to an increasing number and variety of products. The Industry 4.0 conceptualization has several potentials, i.e. flexibility in business and manufacturing processes, where the intelligent and interconnected systems, in particular the Cyber-Physical Production System (CPPS), play a vital role in the whole lifecycle of eco-designed products. In particular, the CPPS represents a suitable way for manufacturers that want to involve their customers, delivering instructions to machines about their specific orders and follow its progress along the production line, in an inversion of normal manufacturing. The development of Info Communication Technologies (ICT) and Manufacturing Science and Technology (MST) enables the innovation of Cyber-Physical Production Systems. However, there are still important challenges that need to be addressed in particular at technological and data analysis level with the implementation of Deep Learning analysis.
MODEL OF SOIL AND WATER CONSERVATION MEASURES APPLICATION BASED ON DISTRICT SPATIAL PLANNING IN MAMASA WATERSHED, SOUTH SULAWESI
Authors: Yusuf Sri Malahayati
Published: October 2019

Depletion of watershed carrying capacity cannot be omitted from mismanagement of the watershed. The integration between SWAT model and remote sensing data are able to identify, assess, and evaluate watershed problem as well as a tool to apply the mitigation of the problem. The aim of this study was to arrange the scenario of watershed management, and decide the best recommendation of sustainable watershed management of Mamasa Sub Watershed. The best recommendation was decided by hydrology parameters, e.i. surface runoff, sediment, and runoff coefficient. Hydrology characteristics of Mamasa Sub Watershed was analyzed based on land use data of year 2012 and climate data for period of 2010-2012. The scenarios were application of bunch and mulch in slope 1-15%; bunch terrace (scenario 1), mulch and strip grass in slope 15-25% (scenario 2), alley cropping in slope 25-40% (scenario 3), and combination scenario 1, 2, 3 with agroforestry in slope > 40% (scenario4). Surface runoff value of Mamasa Sub Watershed is 581.35 mm, while lateral flow, groundwater flow, runoff coefficient, and sediment yield of 640.72 mm, 228.17 mm, 0.29, and 187.213 ton/ha respectively. Based on the scenarios simulation, the fourth scenario was able to reduce surface runoff and sediment yield of 33.441% and of 51.213%, while the runoff coefficient declined to 0.194. Thereby, the fourth scenario is recommended to be applied in Mamasa Sub Watershed so that the sustainability in the watershed can be achieved.
Les entrées en matière non théoriques dans des mémoires de master et des articles de revues
Authors: Daunay Bertrand , Bart Daniel
Published: October 2019

L’article veut contribuer à la description des spécificités du discours scientifique en comparant des entrées en matière de mémoires de master d’étudiants et d’articles d’enseignants-chercheurs. Dans ces entrées en matières, est interrogée la place des références à d’autres univers que le champ théorique, ce qui constitue l’une des questions sensibles dans l’apprentissage de l’écrit académique par de jeunes chercheurs. La comparaison porte sur les items identifiés comme réalisant une référence non théorique dans un corpus de 20 mémoires de master en didactique et de 20 articles issus de 7 revues de didactique. Cette étude exploratoire présente certaines convergences formelles des références non théoriques réalisées dans les écrits des chercheurs et des étudiants mais montre une différence quant au type de référence mobilisé.  Cette analyse se double d’une intention pratique, les résultats de la comparaison donnant lieu à des activités destinées à aider les apprenants à mieux identifier les attentes académiques.
Entre buscar contribuir e la contribution: a modalização em resumos científicos em português/francês
Authors: Loguercio Sandra Dias
Published: October 2019

Relatamos neste artigo um estudo sobre as marcas de modalização em resumos científicos de uma perspectiva interlinguística, com fins pedagógicos. Para além da linguagem comum ao gênero em análise na área de Linguística, em que nos concentramos, esse estudo ajuda a melhor caracterizar o resumo, apontando para posturas adotadas no âmbito do discurso científico. Com base na análise do gênero textual e na exploração lexical de corpora comparáveis em português e francês, combinamos abordagens onomasiológica e semasiológica para comparação entre as línguas. Fruto de normas sociais explícitas (periódicos científicos) e implícitas (quadros culturais e epistemológicos), a linguagem empregada, ao mesmo tempo que confirma a predominância da postura epistêmica, típica da ciência, revela que resumos em português brasileiro são também marcados por uma postura de intenção (volitiva), ao passo que resumos em francês por uma postura de autoafirmação (avaliativa), aspectos a serem considerados pela pedagogia das línguas e da tradução.
O Gênero mapa mental e o letramento do professor de línguas
Authors: Sturm Luciane
Published: October 2019

A formação universitária do professor de línguas apresenta-se como um desafio. Em um curto período, os indivíduos necessitam reconstruir sua identidade, reafirmando-se como professor autônomo e letrado. O desenvolvimento do letramento do professor sofre influências e está sempre vinculado, de alguma forma, aos gêneros de texto que circulam dentro e fora do ambiente acadêmico. Nesse contexto, o objetivo deste trabalho é apresentar, descrever e argumentar a favor do uso do mapa mental (BUZAN, 1995) como instrumento de aprendizagem ao longo da formação em Letras, considerando suas potencialidades para o desenvolvimento da cognição, da criatividade e do letramento do indivíduo. O texto está apoiado nos estudos sobre letramento de Street (1984, 1995, 2008, 2009, 2010), Mattos (2014), Terra (2013). Também, é descrita uma proposta pedagógica para uso dos mapas mentais, apresentando três modelos de interação, que visam à reflexão e à análise das produções pelos próprios acadêmicos.
Academic writing in higher education: focusing on courses of graduate programs of a public Brazilian university
Authors: Dall’Igna Carlla , Moritz Maria Ester Wollstein
Published: October 2019

In the last twenty years researchers have been concerned with the development of higher education students writing literacy (CRISTOVÃO; VIEIRA, 2016; BAZERMAN; MORITZ, 2016). Approaches based on the new literacy studies (LEA; STREET, 1998) recognize the need to learn specific forms of acting in the academic context to successfully participate in such sphere. Considering the importance of academic writing in higher education, this research aims at investigating how academic writing literacy is approached in sixteen graduate programs at a public Brazilian university. One quarter of the university graduate programs were explored as a manner to find courses dealing with academic writing and the content organization of their course plans. Results showed that only fifty percent of the programs investigated offer courses on academic writing and each graduate program approaches academic writing literacy differently. It seems that writing practices in the academic context investigated are still not considered a major issue.
Compreensões sobre a formação para o/do ato de escrever na esfera acadêmica sob a perspectiva histórico-cultural
Authors: Correia Karoliny , Daga Aline Cassol
Published: October 2019

Este artigo discute processos de instrução e desenvolvimento de sujeitos em eventos com a escrita na esfera acadêmica na tentativa de compreender o percurso de formação para o/do ato de escrever. Os dados gerados correspondem à disciplina de Leitura e Produção Textual (LPTA) de uma universidade pública do sul do Brasil, tendo como participantes graduandas em Letras-Português e tutora a distância. Para a análise dos dados, adotou-se epistemologia analítica de base histórico-cultural, que tem como fundamento estudos bakhtinianos e vigotskianos com ênfase na educação em linguagem para a emancipação humana. Os resultados sinalizam para a prevalência de movimentos mais estacionários no que tange à ampliação de repertório cultural dos interactantes em se tratando dos objetos culturais em questão, em especial motivados pela rarefação da ocupação cronotópica dos eventos, o que evidencia que a configuração organizacional de disciplinas de LPTA no ensino superior precisa ser repensada.
O professor universitário como agente letrador: interfaces com o desenvolvimento do letramento acadêmico
Authors: Batista-Santos Dalve Oliveira
Published: October 2019

O objetivo central deste estudo, inserido na área da Linguística Aplicada, é investigar a atuação do professor enquanto agente de letramento (KLEIMAN, 2006) na universidade, com a finalidade de compreender de que forma este agente faz a mediação e o gerenciamento das diferentes vozes numa atividade dialógica de construção de sentidos. Para tanto, esta pesquisa tem orientação interpretativista e utilizou-se da metodologia do Pensar Alto em Grupo–PAG (Cf. ZANOTTO, 1995). A fundamentação teórica relaciona-se aos pressupostos dialógicos do Círculo de Bakhtin e às pesquisas desenvolvidas segundo os pressupostos teórico-metodológicos dos Novos Estudos do Letramento. Os dados revelaram que: a) nas ações (refutando, acatando, ampliando ideias) das participantes, o desenvolvimento do letramento acadêmico foi se constituindo à medida que faziam as leituras críticas, por meio de seus posicionamentos no processo de construção de sentidos; b) a professora foi se constituindo agente letradora, à medida que gerenciava e mediava as vozes das participantes.
O ensino de leitura voltado a universitários indígenas: análise de uma unidade didática à luz dos Estudos de Letramento Acadêmico
Authors: Dilli Camila , Morelo Bruna , Schlatter Margarete
Published: October 2019

O objetivo deste trabalho é apresentar uma unidade didática sobre abstracts e analisar de que modo as tarefas implementam princípios e orientações pedagógicas construídas com base nos Estudos de Letramento Acadêmico (LEA; STREET, 1998, 2006; LILLIS, 2001). O material didático foi desenvolvido para um curso no âmbito das Ações Afirmativas em uma universidade federal brasileira, uma ação pedagógica na área da linguagem que visava à permanência de estudantes indígenas até a diplomação. A partir da perspectiva dos Estudos de Letramento Acadêmico e de diretrizes pedagógicas que privilegiam práticas sociais (RGS, 2009), sintetizamos princípios para orientar o desenho de cursos e orientações para elaboração de tarefas de leitura. A seguir, analisamos de que modo essas diretrizes foram atualizadas no material didático. Por fim, destacamos possíveis contribuições da proposta pedagógica para o enfrentamento de desafios advindos da implementação de políticas que apoiam a ampliação da participação de grupos minoritários na educação superior.
Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice
Authors: Toufaily Chirine , Schang Gauthier , Zhou Xiang , Wartenberg Philipp , Boehm Ulrich , Lydon John P , Roelfsema Ferdinand , Bernard Daniel J
Published: October 2019

The progesterone receptor (PR, encoded by Pgr) plays essential roles in reproduction. Female mice lacking the PR are infertile, due to the loss of the protein’s functions in the brain, ovary, and uterus. PR is also expressed in pituitary gonadotrope cells, but its specific role therein has not been assessed in vivo. We therefore generated gonadotrope-specific Pgr conditional knockout mice (cKO) using the Cre-LoxP system. Overall, both female and male cKO mice appeared phenotypically normal. cKO females displayed regular estrous cycles (vaginal cytology) and normal fertility (litter size and frequency). Reproductive organ weights were comparable between wild-type and cKO mice of both sexes, as were production and secretion of the gonadotropins, LH and FSH, with one exception. On the afternoon of proestrus, the amplitude of the LH surge was blunted in cKO females relative to controls. Contrary to predictions of earlier models, this did not appear to derive from impaired GnRH self-priming. Collectively, these data indicate that PR function in gonadotropes may be limited to regulation of LH surge amplitude in female mice via a currently unknown mechanism.
Presentación
Authors: Espinoza Claudio César
Published: October 2019

Investigaciones Sociales prosigue con este nuevo número en su papel de difusor de las investigaciones realizadas en la Facultad de Ciencias Sociales y de la comunidad académica nacional y mundial. Avanza en su proyecto de proseguir el debate de los problemas actuales y sus implicancias en el futuro del país y del mundo.
El zumbanacuy: enfrentamiento ritual entre negros mayores y negritos bailadores en los Andes centrales de Perú
Authors: García Torres Víctor Manuel
Published: October 2019

Este escrito tiene por objeto reflexionar acerca de una batalla ritual agrícola llamada zumbanacuy protagonizada por la población de Huayucachi, la cual se divide en dos segmentos siguiendo el espacio andino del hatun y urin; han sumado aspectos de su historia local y regional, así como una visión de lo afro que será interpretado bajo el enfoque afroindolatinoamericano. El ritual confronta a dos grupos sociales, los ricos o gamonales y la gente del pueblo, los pobres, los runas o chinchilpos. Se intenta mostrar las diferentes confluencias de lo afroindolatinoamericano en dicho acontecimiento a través de los testimonios de los protagonistas de dicha batalla con fines agrícolas.
El matrimonio místico del chamán y el animismo entre los asháninka del oriente peruano
Authors: Rojas Zolezzi Enrique
Published: October 2019

El presente artículo muestra el lugar del chamán en un sistema cosmológico de carácter animista como el de los asháninka. A partir de su matrimonio con el espíritu del tabaco el chamán asháninka repara las relaciones entre humanos, y humanos con no humanos.
Desarrollo social: San Mateo de Otao y Callahuanca, 2017
Authors: Díaz Encinas Alida Isidora , Meza Arquíñigo Carlos , Vásquez Monge Eduardo Maximiliano , Berrospi Rosales Richard David
Published: October 2019

Al analizar la evolución del desarrollo y los cambios sociales en la población de los distritos de San Mateo de Otao y Callahuanca, Huarochirí 2017, encontramos una serie de transformaciones, principalmente en la agricultura, originalmente de sustento, a una agricultura orientada a la comercialización, para el mercado interno y externo. Esto a pesar de la escasez de agua para el riego, el abandono de los pueblos y anexos que están por encima de 3,000 msnm y la migración de la población joven, restando fuerza a la mano de obra local. También verificamos la falta de atención al patrimonio cultural y a la educación, en cuanto a la salud prevalece la atención primaria. Finalmente para incentivar el proceso del desarrollo y cambios en los componentes sociales de San Mateo de Otao y Callahuanca se necesita implementar políticas de equidad espacial y acciones socioeconómicas para todos los pueblos y anexos, con una adecuada gestión del gobierno local en el uso de suelos y agricultura.
El virrey Abascal, los señores de tierras y los bandoleros en Piura. Anotaciones preliminares sobre la experiencia social y política de José Sapata (a) Palomo (1814-1817)
Authors: Espinoza Claudio César
Published: October 2019

Nuestra investigación busca rastrear las huellas de toda una cultura afrodescendiente de resistencia en el campesinado y de la gente de la ciudad contra otra fuerza social representado por los hacendados como don Francisco Xavier Fernández de Paredes en el valle de La Chira, Querecotillo, provincia de Piura. La documentación judicial de archivo nos permite ahora introducirnos al mundo social rural para conocer los abismos existentes entre el derecho indiano y la práctica social, el mundo social asimétrico y la reproducción de un modelo colonial ilegal en las regiones y provincias para conocer la naturaleza de las acciones de protesta colectiva que transitaban de explosiones de odio campesino hacia movimientos sangrientos que rompían la paz social y de vida de señores y de campesinos labradores de la tierra y ganaderos cotidianos. Examina los acontecimientos de una coyuntura política de crisis regional entre los años de 1814-1817. Es un tiempo social en la que el subdelegado y los alcaldes de SM de Piura han podido percatarse del funcionamiento de dos movimientos sociales todavía no articulados; el primero es el de los cimarrones salteadores y de otro lado, la cuadrilla de José Sapata (a) Palomo, acusado de bandolero que ha recorrido ciudades como Lima y Piura. Esta investigación utiliza los fondos documentales guardados en los archivos judiciales regionales de Piura y Lima.
Sex and Transcatheter Aortic Valve Implantation: Impact of Female Sex on Clinical Outcomes
Authors: Laricchia Alessandra , Bellini Barbara , Romano Vittorio , Khawaja Saud , Montorfano Matteo , Chieffo Alaide
Published: October 2019

Transcatheter aortic valve implantation (TAVI) has emerged as an alternative treatment for severe symptomatic aortic stenosis in patients who are not suitable for surgery or are at high surgical risk. Approximately 50% of patients undergoing TAVI are female and this is reflected by a higher inclusion rate of women in TAVI trials. However, women undergoing TAVI have different baseline clinical characteristics in comparison to men, with fewer comorbidities and a more preserved left ventricular ejection fraction. This translates into favourable outcomes after TAVI, despite a higher rate of peri-procedural complications. This article discusses gender differences in terms of presentation, procedural characteristics and post-procedural results in patients with aortic stenosis undergoing TAVI, with particular focus on possible sex-specific factors affecting outcome.
Visión de la Salud en Apocalipsis
Authors: Ferrer Pablo Manuel
Published: October 2019

En este artículo se propone buscar en algunos textos del Apocalipsis elementos que ayuden a la comprensión de la salud como un bien que debeestar unido a la habitación en un ecosistema sano. Se muestra que la medicina ha sido entendida como un factor de normalización para sostenerecosistemas capitalistas que llamaremos bestiales. Salud y ecología son dosdisciplinas que de concebirse separadas pueden ayudar a sostener ecosistemas opresores, enfermantes.
Salud, vida plena, salvación: miradas ecoteológicas
Authors: López Amós
Published: October 2019

El presente trabajo propone una reflexión ecoteológica sobre los conceptosde salud y salvación con el propósito de orientar acciones para el cuidadode la vida en todas sus manifestaciones. Para ello se sigue un análisisbíblico y teológico que va conectando la salud humana con la saludambiental, mostrando el carácter indisoluble de estos ámbitos de la manode una hermenéutica bíblica que relaciona la ecología con la soteriología.Una teología de la salvación tendrá que ser necesariamente una ecoteologíaque permita redescubrir en la fe elementos ecológicos que favorezcan unasana y equilibrada interrelación entre Dios, la humanidad y el resto de lacreación.
The Legal Fundamentals for the Prevention of Capital Outflow from the Russian Federation
Authors: Ryabova Elena , Nikolaeva Alina
Published: October 2019

Introduction: the identification and analysis of the causes and factors, including the gaps in the legislation, generating an increase in the capital outflow, as well as the improvement of the currency, investment and tax legislation are relevant and important issues. Purpose: to study the problems of the legal regulation to prevent the outflow of capital from the Russian Federation. Methods: the fundamental categories and principles of materialistic dialectics, the generally accepted methods of comparative law became the methodological framework for solving the tasks. As part of the study of the legal foundation to prevent the outflow of domestic capital abroad, the authors also used the methods of analysis and synthesis, functional and systematic approaches, and the formal legal and statistical methods. Results: grounded in the paper the author’s point of view is based on the study of the international conventions, treaties and agreements to which Russia is a party, and the domestic legal acts regulating relations in the field of preventing the outflow of domestic capital abroad, as well as the opinion of the competent academic community. Conclusions: the study identified the characteristic features of the process of capital outflow from Russia and developed a list of recommendations aimed at improving the measures of the state legal regulation in the field of combating the outflow of capital abroad.
The Topical Issues of Coding the Regional Social Security Legislation (On the Example of the Volgograd Region)
Authors: Derkacheva Tatyana
Published: October 2019

Introduction: social security is one of the most important elements of the social policy of the state. Many legal acts are adopted in the social security field. In order to ensure the uniform understanding and interpretation of the content of the normative legal acts in the social security field, their systematization as well as the practical application in the law enforcement process the regional legislators have codified the social security legislation in a number of subjects of the Russian Federation. Using the methods of scientific knowledge, especially the method of system analysis, it is found that the complexity of the problem involves the use of both the law-making and law-realization directions and forms of the legal adaptation of the current legislation of the state. The aim of the study is to conduct a comparative analysis of the social codes adopted in the subjects of the Russian Federation, to identify common approaches in the implementation of the law-making activities for the codification of the social security legislation. The system analysis of the law-making process on the codification of the social security legislation in the subjects of the Russian Federation allowed establishing that the adopted codes had significant differences in structure and content. However, having quite significant differences, the codes have a common property – each of them has one common characteristic – a special part of all adopted social codes is built on a categorical principle. Results: on the basis of the analysis some problems of the law-making activity of the regional legislators on the codification of the social legislation are revealed. Conclusions: 1) it is necessary to adopt a number of federal laws: a codified federal law defining the goals and objectives of the social legislation of the Russian Federation and the subjects of the Russian Federation, the federal law on the sources of law, on the delimitation of powers in law-making between the Russian Federation and its subjects; 2) to establish common principles for the country’s implementation of social security; 3) to develop a single conceptual framework that provides a single legal regime for regulating relations in the social security sphere; 4) to develop a model regional social code as a model for the regional legislators.
The Value of Conclusion by the Results of Public Expertise
Authors: Goncharova Anna
Published: October 2019

Introduction: public expertise is the competent participation of citizens in the management of state affairs and has great potential in improving the quality of decisions and regulations. Currently, however, the conclusion by the results of public expertise is a recommendation. In this regard, it is important to understand the significance of the opinion on the results of public expertise. The purpose of this paper is to determine the value of the conclusion based on the results of public expertise, using the ideas of divisive democracy. Methods: the methodological framework for the study is a set of methods of scientific knowledge, among which the main ones are the method of analysis and the formal logical method. Results: some practical recommendations for improving the legal regulation of public expertise have been developed. Conclusions: the procedure of public expertise should be supplemented by a mandatory stage, which will be the coordination and discussion of the results of public expertise.
Some Problems of Application by Arbitration Court of Simplified Procedures in a Bankruptcy Case
Authors: Kovalenko Svetlana
Published: October 2019

Introduction: the paper investigates the existing problems of the simplified procedure of bankruptcy of absentee debtors and those in liquidation. The parties of the simplified bankruptcy procedure are analyzed, as well as the consequences of the exclusion of persons participating in corporate relations from the USRLE are revealed. The purpose of the study is to systematically analyze the problems of the current legislation on bankruptcy in the framework of a simplified bankruptcy procedure. Methods: the methodology of this article is based on the general scientific approach of positivist materialism. The general scientific methods of cognition are applied: analysis, synthesis, the hypothetical-deductive method, induction; as well as specific scientific methods: legal-dogmatic, systemic, structural-functional. Results: it is proved that at present the legislation is not sufficiently regulated: legal acts do not take into account all the specifics and features of the simplified bankruptcy procedure. The existing methods of solving the problems provided by the law are not always effective; a particular difficulty arises when the debtor is a participant of corporate legal relations. Based on the experience of the arbitration law enforcement, it is proved that the persons controlling the debtor have the possibility of abuse of their right. Conclusions: the legal institution under consideration needs to be permanently improved taking into account the emerging uniformity of the judicial application of the bankruptcy rules. In the absence of institutional innovations in the field of bankruptcy in Russia it is impossible to create a competitive market environment, and moreover, it is impossible to improve the investment climate.