bluuebunny/crossref_metadata_2025 huggingface dataset:
miR-17-5p drives G2/M-phase accumulation by directly targeting CCNG2 and is related to recurrence of head and neck squamous cell carcinoma
Authors: Huang Qiang , Shen Yu-Jie , Hsueh Chi-Yao , Guo Yang , Zhang Yi-Fan , Li Jiao-Yu , Zhou Liang
Published: October 2021

Background

The human miR-17-92 polycistron is the first reported and most well-studied onco-miRNA with a cluster of seven miRNAs. miR-17-5p, a member of the miR-17-92 family, plays an important role in tumor cell proliferation, apoptosis, migration and invasion. However, few studies have shown the role of miR-17-5p in the cell cycle of head and neck squamous cell carcinoma (HNSCC).

Methods

RT-qPCR was used to detect miR-17-5p expression levels in 64 HNSCC tissues and 5 cell lines. The relationship between the expression of miR-17-5p in the tissues and the clinical characteristics of the patients was analyzed. HNSCC cells were transfected with an miR-17-5p mimic or inhibitor to evaluate cell cycle distribution by flow cytometry. Cell cycle distribution of cells transfected with target gene was evaluated using flow cytometry. Dual-luciferase reporter assay was used to detect the regulatory effect of miR-17-5p on target gene expression.

Results

In the present study, we found that miR-17-5p expression in HNSCC tissues and cell lines was remarkably increased, and miR-17-5p is related to recurrence in HNSCC patients. Silencing miR-17-5p blocked HNSCC cells in G2/M phase, whereas its overexpression propelled cell cycle progression. More importantly, we verified that miR-17-5p negatively regulated CCNG2 mRNA and protein expression by directly targeting its 3’UTR.

Conclusion

These findings suggest that miR-17-5p might act as a tumor promoter and prognostic factor for recurrence in HNSCC patients.
Differential scanning calorimetric investigations of three rotary nickel-titanium instrument systems before and after simulated clinical uses
Authors: Van Pham Khoa
Published: October 2021

Background

The transformation temperatures were important values, influencing the mechanical properties and clinical performance of nickel-titanium instruments. The aim of this study was to determine the transformation temperatures of three rotary nickel-titanium (NiTi) instruments: Reciproc, HyFlex CM Pro, and Neoniti before and after simulated clinical uses.

Methods

Ninety new NiTi instruments of three single-file instruments: Reciproc, HyFlex CM Pro, and Neoniti were divided into three groups. Thirty instruments of each group were divided into 3 subgroups (10 instruments for each subgroup): new, one-time simulated clinical used and sterilised, and three times simulated clinical used and sterilized subgroups. The instruments were in the as-received condition for the new subgroups, one time used in the plastic endo-training blocks and sterilised for the one-time subgroups, and three times used in the plastic endo-training blocks and sterilised for the three times subgroups. Each instrument in subgroups was cut into four small segments of 4–5 mm. All segments of instruments were analysed using Differential Scanning Calorimetry (DSC). Data was collected and analysed using SPSS version 20.0 with ANOVA test or Kruskal–Wallis test at the significant level of 0.05.

Results

There was not significant difference between before and after simulated clinical use with sterilised procedure in three NiTi instrument systems. The austenite-finish (Af) temperatures of three instrument systems were higher than that of the human body (37 °C), of these, the Af temperature of Neoniti was highest and that of HyFlex CM Pro was lowest.

Conclusions

The austenite-finish (Af) temperatures of three NiTi instruments were higher than that of human body temperature, therefore, material was in the phase transformation from martensite to austenite, gives the instruments more flexibility when used in the clinical situation.
miRNAs in decidual NK cells: regulators worthy of attention during pregnancy
Authors: Li Liman , Feng Ting , Zhou Weijie , Liu Yuan , Li Hong
Published: October 2021

The critical immune effectors, including T, B, and natural killer (NK) cells, dendritic cells, and macrophages participate in regulating immune responses during pregnancy. Among these immune cells, decidual NK (dNK) cells are involved in key placental development processes at the maternal–fetal interface, such as uterine spiral artery remodeling, trophoblast invasion, and decidualization. Mechanistically, dNK cells significantly influence pregnancy outcome by secreting cytokines, chemokines, and angiogenic mediators and by their interactions with trophoblasts and other decidual cells. MicroRNAs (miRNAs) are small non-coding RNA molecules that participate in the initiation and progression of human diseases. Although the functions of circulating miRNAs in pathological mechanism has been extensively studied, the regulatory roles of miRNAs in NK cells, especially in dNK cells, have been rarely reported. In this review, we analyze the effects of miRNA regulations of dNK cell functions on the immune system during gestation. We discuss aberrant expressions of certain miRNAs in dNK cells that may lead to pathological consequences, such as recurrent pregnancy loss (RPL). Interestingly, miRNA expression patterns are also different between dNK cells and peripheral NK (pNK) cells, and pNK cells in the first- and third‐trimester of gestation. The dysregulation of miRNA plays a pivotal regulatory role in driving immune functions of dNK and pNK cells. Further understanding of the molecular mechanisms of miRNAs in dNK cells may provide new insights into the development of therapeutics to prevent pregnancy failure.
TTK is a potential therapeutic target for cisplatin-resistant ovarian cancer
Authors: Liu Yixuan , Zhu Keyu , Guan Xiaolin , Xie Suhong , Wang Yanchun , Tong Ying , Guo Lin , Zheng Hui , Lu Renquan
Published: October 2021

Background

Drug resistance and recurrence are main contributors to the poor prognosis of ovarian cancer. Cisplatin is a platinum compound which is widely used in the treatment of various solid tumors including ovarian cancer. Up to now, the mechanism of cisplatin resistance in ovarian cancer is unclear. Threonine and tyrosine kinase (TTK), an integral part of the spindle assembly checkpoint, may be a potential new target associated with chemotherapy sensitivity.

Results

TTK was up-regulated in the cisplatin-resistant ovarian cancer cell line. Down-regulation of TTK could recover the sensitivity of cisplatin-resistant ovarian cancer cells to cisplatin treatment. Mechanistically, the PI3K/AKT signaling pathway was activated in cisplatin-resistant cells, and this pathway would be affected by TTK expression. Furthermore, TTK was highly expressed in the tissues of ovarian cancer patients, especially those acquired resistance to cisplatin.

Conclusions

Our study revealed that TTK may be a promising therapeutic target for cisplatin-resistant ovarian cancer.
Health system and patient-level factors serving as facilitators and barriers to rheumatic heart disease care in Sudan
Authors: Edwards Jeffrey G. , Barry Michele , Essam Dary , Elsayed Mohammed , Abdulkarim Mohamed , Elhossein Basamat M. A. , Mohammed Zahia H. A. , Elnogomi Abdelmunim , Elfaki Amna S. E. , Elsayed Ahmed , Chang Andrew Y.
Published: October 2021

Background

Rheumatic heart disease (RHD) remains a leading cause of morbidity and mortality in Sub-Saharan Africa despite widely available preventive therapies such as prophylactic benzathine penicillin G (BPG). In this study, we sought to characterize facilitators and barriers to optimal RHD treatment with BPG in Sudan.

Methods

We conducted a mixed-methods study, collecting survey data from 397 patients who were enrolled in a national RHD registry between July and November 2017. The cross-sectional surveys included information on demographics, healthcare access, and patient perspectives on treatment barriers and facilitators. Factors associated with increased likelihood of RHD treatment adherence to prophylactic BPG were assessed by using adjusted logistic regression. These data were enhanced by focus group discussions with 20 participants, to further explore health system factors impacting RHD care.

Results

Our quantitative analysis revealed that only 32% of the study cohort reported optimal prophylaxis adherence. Younger age, reduced primary RHD healthcare facility wait time, perception of adequate health facility staffing, increased treatment costs, and high patient knowledge about RHD were significantly associated with increased odds of treatment adherence. Qualitative data revealed significant barriers to RHD treatment arising from health services factors at the health system level, including lack of access due to inadequate healthcare staffing, lack of faith in local healthcare systems, poor ancillary services, and patient lack of understanding of disease. Facilitators of RHD treatment included strong interpersonal support.

Conclusions

Multiple patient and system-level barriers to RHD prophylaxis adherence were identified in Khartoum, Sudan. These included patient self-efficacy and participant perception of healthcare facility quality. Strengthening local health system infrastructure, while enhancing RHD patient education, may help to improve treatment adherence in this vulnerable population.
Verifiable image revision from chameleon hashes
Authors: Xu Junpeng , Chen Haixia , Yang Xu , Wu Wei , Song Yongcheng
Published: October 2021

In a digital society, the rapid development of computer science and the Internet has greatly facilitated image applications. However, one of the public network also brings risks to both image tampering and privacy exposure. Image authentication is the most important approaches to verify image integrity and authenticity. However, it has been challenging for image authentication to address both issues of tampering detection and privacy protection. One aspect, image authentication requires image contents not be changed to detect tampering. The other, privacy protection needs to remove sensitive information from images, and as a result, the contents should be changed. In this paper, we propose a practical image authentication scheme constructed from chameleon hashes combined with ordinary digital signatures to make tradeoff between tampering detection and privacy protection. Our scheme allows legitimate users to modify contents of authenticated images with a privacy-aware purpose (for example, cover some sensitive areas with mosaics) according to specific rules and verify the authenticity without interaction with the original authenticator. The security of our scheme is guaranteed by the security of the underlying cryptographic primitives. Experiment results show that our scheme is efficient and practical. We believe that our work will facilitate image applications where both authentication and privacy protection are desirable.
Characteristics of Growth in Children With Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency During Adrenarche and Beyond
Authors: Troger Tobias , Sommer Grit , Lang-Muritano Mariarosaria , Konrad Daniel , Kuhlmann Beatrice , Zumsteg Urs , Flück Christa E
Published: October 2021

Context

Patients with classic congenital adrenal hyperplasia (CAH) often do not achieve their full growth potential. Adrenarche may accelerate bone maturation and thereby result in decreased growth in CAH.

Objective

The study aimed to analyze the impact of growth during adrenarche on final height of adequately treated classic CAH patients.

Methods

This retrospective, multicenter study (4 academic pediatric endocrinology centers) included 41 patients with classical CAH, born 1990-2012. We assessed skeletal maturation (bone age), growth velocity, and (projected) adult height outcomes, and analyzed potential influencing factors, such as sex, genotype, and glucocorticoid therapy.

Results

Patients with classic CAH were shorter than peers (−0.4 SDS ± 0.8 SD) and their parents (corrected final height −0.6 SDS ± 1.0 SD). Analysis of growth during adrenarche revealed 2 different growth patterns: patients with accelerating bone age (49%), and patients with nonaccelerating bone age relative to chronological age (BA-CA). Patients with accelerating BA-CA were taller than the normal population during adrenarche years (P = 0.001) and were predicted to achieve lower adult height SDS (−0.9 SDS [95% CI, −1.3; −0.5]) than nonaccelerating patients when assessed during adrenarche (0.2 SDS [95% CI, −0.3; 0.8]). Final adult height was similarly reduced in both accelerating and nonaccelerating BA-CA groups (−0.4 SDS [95% CI, −0.9; 0.1] vs −0.3 SDS [95% CI, [−0.8; 0.1]).

Conclusion

Patients with and without significant bone age advancement, and thus differing height prediction during adrenarche, showed similar (predicted) final height when reassessed during pubertal years. Bone age alone should not be used during adrenarche as clinical marker for metabolic control in CAH treatment.
Comparison of clinical efficacy of suprapatellar and infrapatellar intramedullary nailing in treating tibial shaft fractures
Authors: Zhu Zhonglian , Wang Zhaodong , Zhou Pinghui , Wang Xuyi , Guan Jianzhong
Published: October 2021

Objectives: To compare clinical efficacies of suprapatellar and infrapatellar intramedullary nailing approaches in treating tibial shaft fractures.

Methods: Patients (n=110) admitted with tibial shaft fractures in our hospital from January 2017 to June 2020, who underwent procedures with internal fixation intramedullary nails, were retrospectively divided into suprapatellar and infrapatellar approach groups (n=55 each) based on the surgical method used for fracture repair. The clinical and functional outcomes of the knee were assessed six months after the surgery

Results: Six months after the operation, the pooled value for excellent and good efficacy rates in the suprapatellar approach group, as indicated by Hospital for Special Surgery (HSS) Knee scoring system, was 90.91%, which was significantly higher than that in the infrapatellar approach group (76.36%). The degree of pain (visual analogue scale (VAS) score) of the patients in the suprapatellar approach group was over 2-fold lower than in the infrapatellar approach group (P < 0.001).The Lysholm knee score, range of motion (ROM), SF-36p, and SF-36M scores in the suprapatellar approach group were significantly higher than those in the infrapatellar approach group (P < 0.001).

Conclusion: Suprapatellar approach had significantly higher clinical efficiency than infrapatellar approach, and can significantly reduce the degree of pain, promote the recovery of patients with knee joint involvement, improve the physical and psychological well-being, reduce the number of cases of postoperative delayed healing.

doi: https://doi.org/10.12669/pjms.37.7.4766

How to cite this:Zhu Z, Wang Z, Zhou P, Wang X, Guan J. Comparison of clinical efficacy of suprapatellar and infrapatellar intramedullary nailing in treating tibial shaft fractures. Pak J Med Sci. 2021;37(7):---------.  doi: https://doi.org/10.12669/pjms.37.7.4766

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Digital Product Perception and User Satisfaction Relationship: Can They Create Feedback Intention?
Authors:   School of Business and Management, Institut Teknologi Bandung, Indonesia, Kencanasari Retna Ayu Mustikarini , Dhewanto Wawan , Rustiadi Sonny
Published: October 2021

Agile product development principles emphasize user collaboration and continuous improvement. It sometimes bothers users if they have less time, commitment and knowledge to become involved in the lengthy process of product development. Giving online feedback could be another way of contributing to product improvement. However, not all users are willing to leave reviews on online platforms. This study attempts to uncover the factors behind user feedback intention and the relationship between user roles in an agile approach. The questionnaire was completed by 113 respondents from all over Indonesia who have knowledge and experience in using digital products. The data was processed further by applying the PLS-SEM technique using the SmartPLS 3 application. The proposed model supported the positive influence of product perception on user satisfaction, and user satisfaction’s positive impact on feedback intention. Product perception is the first-order construct of attitude and perceived usefulness; meanwhile, perceived quality is influenced by product perception. This study's theoretical contribution sheds light on the relationship between user satisfaction, perception and feedback intention. Moreover, it provides practitioners practical implications towards understanding how to gather user feedback to support the initial idea in product improvement using an agile approach. Keywords: Agile product development, digital start-ups, feedback intention, product perception, user satisfaction
Strengthening Human Capital Department Roles through Building Collaboration with External Stakeholders
Authors:   School of Business and Management, Institut Teknologi Bandung, Indonesia, Khristiningrum Veronica Afridita , Gustomo Aurik , Ginting Henndy
Published: October 2021

Human capital department is found to have important roles in supporting the business objectives of a company. High competition in the customer goods industry makes the company strengthen its human capital department role because the human capital department becomes a strategic business partner. Most companies enhance their human capital departments internally, but internal resources have limitations in developing human capital department roles. The human capital department needs to look further to external resources that could support their roles. To strengthen human capital department roles through collaboration with external stakeholders needs further examination. This paper aimed to explore the external stakeholders in strengthening human capital department roles in consumer goods companies. Based on qualitative, semi-structured interviews of human capital leaders from five consumer goods companies in Indonesia, we identify six stakeholders based on the human capital department activities leading to human capital department roles. The external factors include outsourcing, vendors, government, business and professional associations, community, and university. Collaboration with these stakeholders strengthen the human capital department roles of consumer goods company. Keywords: Collaboration, consumer goods, external stakeholders, human capital department roles, Indonesia
Does the nursing curriculum influence feelings of gender-role conflict in a cohort of nursing degree male students?
Authors: Christensen Martin , Purkis Nick , Morgan Raph , Allen Chris
Published: October 2021

It is estimated that more than 9% of the global nursing workforce is male and that this share will gradually rise over the next decade. Although there are some positive aspects of having a male nursing workforce, men in the profession still experience discriminatory behaviours and practices. Fortunately, this does not deter a number of men entering undergraduate degree programmes. The aim of this study was to understand the experiences of 14 male nursing students in their first year of the adult Bachelor of Nursing programme. Using the Inventory of Male Friendliness in Nursing Programs and the Gender Role Conflict Scale, this study found that the male students felt welcomed, supported and included into the nursing programme. In addition, they felt no overall gender-role conflict, although feelings of success and achievement caused some challenges. The results of this study suggest that the male students did not necessarily experience those inequitable behaviours and practices reported in the literature. It has been suggested that perhaps the reality of clinical practice may change the perception of nursing for male students. Therefore, implications for further research could include a longitudinal study to ascertain where the perceptions of the nursing programme change for the male nursing students over time.
Independent review seeks to tackle obesity and other diet-related diseases
Authors: Glasper Alan
Published: October 2021

Emeritus Professor Alan Glasper, from the University of Southampton, discusses a recent government-commissioned review on the food system of the UK
We need a clear strategy on vaccination
Authors: Foster Sam
Published: October 2021

The outcome of a consultation on mandatory COVID-19 vaccination for health and social care staff must result in a standard approach being taken nationwide, argues Sam Foster, Chief Nurse, Oxford University Hospitals
ANÁLISE DA PERCEPÇÃO DOS GESTORES E EMPREGADOS ACERCA DO COMPORTAMENO INOVADOR EM UMA INDÚSTRIA AUTOMOBILÍSTICA
Authors: De Muylder Cristiana Fernandes , Araújo Liliane Andrade , La Falce Jefferson Lopes , Mesquita Sander Rosa de Laia
Published: October 2021

O artigo tem como objetivo analisar o comportamento inovador sob as dimensões apresentadas no estudo de De Jong e Den Hartog (2010) pela ótica do gestor e do empregado no setor industrial do estado de Minas Gerais. Para o estudo da percepção do empregado, utilizaram-se como instrumento de pesquisa os estudos realizados por Scott e Bruce (1994) e Janssem (2000). Trata-se de uma pesquisa descritiva com uma metodologia quantitativa, realizada por meio de uma survey monkey, nos períodos de novembro de 2016 e maio de 2017. Percebeu-se uma motivação expressiva dos gestores para instigar o comportamento inovador nos funcionários, porém esta foi pouco percebida sob a ótica dos empregados, o que corrobora os resultados da academia segundo os quais os gestores e empregados necessitam convergir para o desenvolvimento organizacional, dessa forma a empresa terá oportunidades de se destacar no setor de atuação.
ESFORÇO INATIVO E PROCESSO DE APRENDIZADO DA INDÚSTRIA METAL-MECÂNICA PÓS-COLHEITA DE PANAMBI-RS
Authors: Geremia Fabiano , Viegas Thales de Oliveira Costa , Silva Leão Claudio José , Moura Rafael Alves de
Published: October 2021

O objetivo deste trabalho é investigar as características do esforço inovativo e dos processos de aprendizagem que ocorrem no interior da indústria metal mecânica pós-colheita de Panambi – RS. O trabalho analisa as especificidades e condições de desenvolvimento desta indústria no município e, sobretudo, as características dessa estrutura produtiva, os processos de aprendizagem, as formas de governança, e o conjunto de externalidades associados àquele parque fabril. Com base na literatura Neo-Schumpeteriana foi realizada uma pesquisa de campo com questionário estruturado para subsidiar a análise das características tecnológicas das empresas. Conclui-se que esse sistema produtivo realiza, rotineiramente, esforços inovativos, de natureza, predominantemente, incremental, que resultam em impactos relevantes na competitividade das empresas, a partir da criação de um círculo virtuoso de crescimento local.
DESEMPENHO DAS COMPRAS GOVERNAMENTAIS: REVISÃO DA LITERATURA NACIONAL RECENTE E PROPOSIÇÃO DE UMA AGENDA DE PESQUISA
Authors: De Rezende Elvira Carolina Moreira , Moreira Marina Figueiredo
Published: October 2021

Neste estudo, buscou-se investigar como a literatura tem averiguado o desempenho de uso das compras governamentais para implementação de políticas públicas no Brasil, por meio do mapeamento do estado da arte em revisão exaustiva da literatura do decênio 2007-2017. A relevância desta pesquisa reside na apresentação do panorama nacional das pesquisas concernentes ao desempenho das compras governamentais, contribuindo, assim, à literatura de Administração Pública e ao debate referente à avaliação do uso das compras governamentais.  Entende-se que três categorias temáticas sumarizam a literatura: Resultados de uso das compras; Uso de modelos multicritério para a avaliação do desempenho de compras; e Uso do poder de compra do Estado. Compõe-se agenda de pesquisa pautada em duas lacunas: desenvolvimento de estudos que testem o desempenho das compras sob perspectiva comparada e multicritério; e que testem variáveis teóricas típicas do uso das compras em políticas públicas, como satisfação do usuário, transparência ou accountability.
A NECESSIDADE DE AÇÕES DE INOVAÇÃO NA UNIVERSIDADE
Authors: Pazmino Ana Veronica
Published: October 2021

A pesquisa apresenta o tema da inovação aberta e o papel de destaque que a universidade pode ter no fomento de parceria com o mercado, propriedade intelectual, empreendedorismo e incubação de empresas. O objetivo geral foi identificar as ações de inovação na universidade e analisar o ranking por indicador de inovação das universidades Brasileiras. A pesquisa seguiu um processo metodológico científico descritivo, em que foram levantados por meio de pesquisa documental o tema da inovação nas universidades e ações de inovação na universidade Brasileira. Os resultados mostram que a cultura de propriedade intelectual e inovação no país ainda é pouco difundida, tanto no âmbito das universidades como no setor produtivo.
INOVAÇÃO E O MERCADO DE CERVEJA ARTESANAL FLUMINENSE
Authors: Priori de Deus Elisa , Falcão de Oliveira Prof. Dr. Carlyle Tadeu
Published: October 2021

Os sistemas de coworking são espaços que oferecem flexibilidadeparaseususuárioscomrelaçãoaoscustos,e,porisso,seusprincipais atores são freelancers ou/e startups. As cervejarias ciganas, cervejarias sem fábricas que produzem no espaço da outra cervejaria, podem ser consideradas um modelo coworking. Os coworking cervejeiros fluminenses criam relações de parceria para produzir sua cerveja artesanal. Este trabalho procurou identificar a contribuição das cervejarias artesanais para a teoria da inovação cooperativa e do mercado cervejeiro. Para isso, utilizaram-se pesquisas bibliográfica, documental e entrevistas em profundidade com análises qualitativas. Foram pesquisadas 154 microcervejarias fluminenses. Observou-se que a inovação cooperativa nos coworking cervejeiros possibilita que pequenas empresas desenvolvam seu produto e ingressem no mercado, assim como a introdução de novas parcerias promove o fortalecimento da disseminação das cervejas artesanais entre os consumidores do estado do Rio de Janeiro.
O EFEITO DO BIG DATA ANALYTICS NA RELAÇÃO ENTRE GESTÃO ESTRATÉGICA DA LOGÍSTICA EM SERVIÇOS E DESEM´PENHO OPERACIONAL
Authors: Cesar Dirceu Gonçalves , Moori Roberto Giro
Published: October 2021

Este artigo, de natureza exploratória do tipo quantitativo, analisou a satisfação do cliente no comércio eletrônico, em especial atenção sobre o efeito mediador do uso da Big Data Analytics na relação entre gestão estratégica da logística de serviços e o desempenho operacional. Foram obtidos 98 questionários junto a gestores logísticos de empresas de ecommerce. Os dados tratados pela modelagem em equações estruturais, a técnica do Partial Least Square, Path Modeling (PLS-PM), em nível de significância estatística (α ≤ 0,05), revelou que o Big Data Analytics mediou parcialmente a relação entre gestão estratégica da logística de serviços e o desempenho operacional logístico, por sua vez, influenciou positivamente na satisfação do cliente. Esse resultado apresentou implicações para a teoria e para as práticas gerenciais.Palavras-chave: big data analytics; gestão estratégica da logística; desempenho operacional
Effects of dietary fiber sources on bacterial diversity in separate segments of the gastrointestinal tract of native and exotic pig breeds raised in Vietnam
Authors: Ngoc Tran Thi Bich , Oanh Nguyen Cong , Hong Tran Thi Thu , Dang Pham Kim
Published: October 2021

Background and Aim: Dietary fiber has distinctive effects on the environment and microbiota of the pig's intestinal tract. This study was conducted at the naturally ventilated facility of the experimental station, National Institute of Animal Sciences, Vietnam, to examine the effects of fiber sources in diets on the intestinal microbiota of two different pig breeds raised in Vietnam.

Materials and Methods: A total of 18 native and 18 exotic pigs with average initial body weights of 9.5±0.4 and 16.5±0.4 kg, respectively, were each divided into three dietary treatments, including a low-fiber diet containing approximately 200 g NDF per kg dry matter (DM) and two high-fiber diets containing cassava by-products or brewer's grains containing approximately 300 g NDF per kg DM. At the end of the experiment (28 days), the bacterial diversity of digesta samples collected from the stomach, ileum, and colon segments was analyzed through DGGE analysis of the V3 variable regions of 16S-rDNA and by cloning and sequencing.

Results: Among the diets, significant differences were observed in the number of DNA bands in the stomach between the native and exotic pigs (p<0.05), but not in the ileum and colon. The dietary fiber affected the number of DNA bands in the ileum (p<0.05), but not in the stomach and colon. A significant interaction effect was found between diet and breed on the number of DNA bands in the ileum (p<0.05). Dietary fiber and breed had a greater effect on microbiota in the ileum and colon than that in the stomach.

Conclusion: The fiber sources affected the number of DNA bands in the ileum, and breed affected the number of DNA bands in the stomach. The microbial compositions in the ileum and colon segments were significantly affected by the dietary fiber and breed.
Low temperatures or high isolation delay increases the average COVID-19 infections in India : A Mathematical modeling approach
Authors: Prakash D Bhanu , Chhetri Bishal , Vamsi D K K , Balasubramanian S , Sanjeevi Carani B
Published: October 2021

The dynamics of COVID-19 in India are captured using a set of delay differential equations by dividing a population into five compartments. The Positivity and Boundedness of the system is shown. The Existence and Uniqueness condition for the solution of system of equations is presented. The equilibrium points are calculated and stability analysis is performed. Sensitivity analysis is performed on the parameters of the model. Bifurcation analysis is performed and the critical delay is calculated. By formulating the spread parameter as a function of temperature, the impact of temperature on the population is studied. We concluded that with the decrease in temperature, the average infections in the population increases. In view of the coming winter season in India, there will be an increase in new infections. This model falls in line with the characteristics that increase in isolation delay increases average infections in the population.
Mathematical modeling of AZ30 magnesium alloys at high temperature using the ring compression test and genetic algorithm method
Authors: Barati Farzan , Esfandiari Mona , Babaei Sajjad , Hoseini-Tabar Zahra , Atarod Aida
Published: October 2021

In the present investigation, a new method is proposed to study the AZ30 flow curve at elevated temperatures and various strain rate. Experiments were carried out with the goal of obtaining flow curve of AZ30 at three different temperature and strain rates by using the ring test method. The presented work aims to develop a model using genetic algorithm for AZ30 flow stress prediction during different test conditions. The Santam machine was implicated that was able to perform experiments by controlling both the position and load modes. At each temperature and strain rate the isothermal test was performed respectively. In the present investigation for three varios temperatures and strain rates, 54 ring compression tests were carried out with different levels of reduction in height. Then each specimen was water cooled quickly to investigate the microstructure of AZ30 magnesium alloy by using optical microscope. The model used in the present study was able to predict the flow curve with an 2.3% accuracy. This model has excellent potential to be employed in various industry applications.
Readability and adaptation of children’s literary works from the perspective of ideational grammatical metaphor
Authors: Liu Yan
Published: October 2021

Widely studied in fields like education, psychology, and linguistics, readability can be defined as (a) reader’s understanding of a reading text, (b) features of a text, or (c) the matching of a text to its reader. The existing research has been focused on the formulaic and multilevel discourse approaches, relatively neglecting others such as systemic functional linguistics oriented one. Moreover, contemporary reading materials pose a challenge for average children in many ways. This study examines readability and adaptation of children’s literary works from the perspective of ideational grammatical metaphor inspired by systemic functional linguistics. Through case studies of metaphorical transferences involving zero, one, two, and three ideational grammatical metaphors used in the parallel excerpts in the original version ofAlice’s Adventures in Wonderlandand its eight adapted ones published in China, it is concluded that addition, maintenance, revision, unpacking, and demetaphorization are five major strategies which are found to decrease, maintain, or increase readability of some parts in the adapted versions.
Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
Authors: Hadi Sutopo , Fenska Mona Dwi , Noviany Noviany , Satria Heri , Simanjuntak Wasinton , Naseer Muhammad Moazzam
Published: October 2021

This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine.
Johanna Seibt’s Process Ontology of Categorical Inference: On Nomological Axiomatics and Category Projection
Authors: Erkan Ekin
Published: October 2021

Drawing from a Sellarsian realist-naturalist epistemology, we trace different levels of cognitive hierarchy procedures through which a representational system learns to update its own states and improve its ‘map-making’ capabilities from pre-conscious operations which modulate base-localization functions, to patterns of epistemic revision and integration at the conceptual and theoretical levels, producing a nomological double of its world. We show how ontological theorization becomes diachronically coordinated with and constrained by empirical science, and how the formal-quantitative kernel of scientific theories corresponds to qualitative-conceptual determinations at the structural level. Following Johanna Seibt’s characterization of ontology as a theory of categorial inference, we trace the preservation of inferential semantic structure across ontological theories in relation to model languages and provide provisional indications to coordinate Seibt’s account with a convergent realist assessment of systematic modeling, defining the epistemological conditions for articulating the preservation of formal structure in theories toward a limit-point of enquiry.
Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application
Authors: Wang Wenzhao , Zhang Boqing , Zhao Lihong , Li Mingxin , Han Yanlong , Wang Li , Zhang Zhengdong , Li Jun , Zhou Changchun , Liu Lei
Published: October 2021

Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing is an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, the composite scaffolds of polylactic acid (PLA) and nano-hydroxyapatite (n-HA) were manufactured by the fused deposition modeling (FDM) technique. Equal mass PLA and n-HA were uniformly mixed to simulate the organic and inorganic phases of natural bone. The suitability of the composite scaffolds was evaluated by material characterization, mechanical property, and in vitro biocompatibility, and the osteogenesis induction in vitro was further tested. Finally, the printed scaffold was implanted into the rabbit femoral defect model to evaluate the osteogenic ability in vivo. The results showed that the composite scaffold had sufficient mechanical strength, appropriate pore size, and biocompatibility. Most importantly, the osteogenic induction performance of the composite scaffold was significantly better than that of the pure PLA scaffold. In conclusion, the PLA/n-HA scaffold is a promising composite biomaterial for bone defect repair and has excellent clinical transformation potential.
Creencia y pertenencia: El laberinto de las sociedades posotomanas
Authors: ALNASIR Samer
Published: October 2021

Post-colonial coagulation is the dilemma of many societies in endless formation due to the aftermath of colonialism and the dominance of coloniality, and even more so when this aftermath has been converted into a never-ending labyrinth for political-Islamic anthropology, particularly in the Arab case. The present study primarily aims to analyze the emergence of Abrahamic religions among Arab tribes and their role in supplanting the canon of identity and belonging, forming a universal standard for legal identity substantially different from the European one, and overturning the ancient tribal concept. The study then shifts to analyz-ing the formation of Islamic ideology as positive law by means of an empirical parallelism with Roman law, thus introducing the Latin concept of interpolare. We therefore arrive at the conclusion of how foreign-colonial interference played the main role in diluting the identity canon and that of belonging, creating a false identity, shaped to conform to colonial compromises, wrapping religious epistemology in a forced normative system to have caused schizophrenia and cognitive resistance to power and normative disobe-dience, even prompting schizophrenia and an aversion to reality.
Cultura política e política de massas: aproximações entre integralismo e neointegralismo
Authors: ZANELATTO J. H.
Published: October 2021

The Ação Integralista Brasileira [Brazilian Integralist Action] movement was founded in São Paulo by Plínio Salgado in 1932. Conservative and ultra-nationalist in character, it rapidly expanded across the entirety of Brazil, with one of the drivers of its success the constitution of symbolic rituals to materialize by means of parades in urban squares and streets. The aim of this article is therefore to demonstrate how Brazil’s city streets served as a space for the AIB’s propaganda, as well as revealing how these spaces were used to materialize Integralist symbology and rituals. The article also aims to outline the AIB’s reorganization post-1945 and to highlight the movement’s connection with Neo-Integralism in the twenty-first century, identifying Integralism as a political culture.
Risk Factors for Prognosis after the Maze IV Procedure in Patients with Atrial Fibrillation Undergoing Valve Surgery
Authors: Yang Hui , Zou Pu , He Yuhu , Huang Lingzhi , Zhou Xinmin , Liu Liming , Liu Zhenjiang , Zhou Shenghua
Published: October 2021

The present study evaluated risk factors related to persistent atrial fibrillation (AF) at discharge (AF-d) and recurrent atrial fibrillation (rAF) and all-cause death after the maze IV procedure. Two hundred nineteen patients (63 female, aged 52.5±8.8 years) with valve disease and persistent AF undergoing valve surgery and the maze IV procedure in our center between 2015 and 2016 were included. Baseline demographic and clinical data were obtained by review of medical records. The median follow-up period was 27 months (interquartile range 21–34 months) in our patient cohort. The primary end point was all-cause death. The secondary end point was AF-d or rAF. rAF is defined as AF recurrence at 3 months or later after the procedure. Twenty-eight patients (12.8%) died during follow-up. Multiple logistic regression analysis showed that thrombocytopenia, elevated serum total bilirubin level, a larger right atrium, AF-d, and rAF were independent determinants for all-cause death after the maze IV procedure after adjustment for age, sex, and clinical covariates, including New York Heart Association class III/IV disease, hypertension, and aortic regurgitation, while valvular disease duration and left atrial diameter greater than 80.5 mm were independent determinants for AF-d, and thrombocytopenia, elevated serum total bilirubin level, higher mean pulmonary artery pressure, and AF-d were independent predictors for rAF. In conclusion, thrombocytopenia, elevated serum total bilirubin level, an enlarged right atrium, AF-d, and rAF are independent predictors of all-cause death in patients undergoing the maze IV procedure.
Acción política y social de los pueblos originarios en favor de la configuración del Estado plurinacional comunitario
Authors: Cárdenas Arias Julián , Idrobo Velasco Jhon Alexander , León Ana María , Orrego Echeverría Israel Arturo
Published: October 2021

El siguiente documento parte de premisas previas, para demostrar cómo los cambios constitucionales en Bolivia se materializaron a través de acciones sociales y políticas sustentadas en las prácticas y conocimientos ancestrales de los pueblos originarios, dando paso a la construcción del Estado plurinacional comunitario. Así, al abordar el análisis sobre la conformación de Estados plurinacionales en América Latina, se busca evidenciar cambios políticos y epistémicos que experimentan actualmente algunos países en la región. Procesos que son desconocidos por su mínima difusión académica, reduciendo y confundiendo el término plurinacional con otros, como multiculturalismo, pluriculturalismo o multietnicidad, entre muchos más, que desdibujan la postura de esta forma organizativa. En este sentido, aclarar, analizar y entender las apuestas políticas y epistémicas de los Estados plurinacionales permite evidenciar discursos y prácticas propias de países donde la presencia de los movimientos y organizaciones sociales de tipo étnico marcan una multiplicidad de horizontes en diferentes planos, en oposición al condicionamiento de la línea unidimensional de la lógica de los Estados liberales, herencia de la tradición europea, que excluyen por medio de distintos dispositivos otras formas de asumir lo político, lo humano, lo ético y lo científico.
La educación en tiempos de crisis. Diálogos en torno a lo humano
Authors: Saldaña Duque Reina , Hernández Rodríguez Christian Andrés , Pino Salamanca Stella , Montenegro Mora Luis Alberto
Published: October 2021

Este texto es resultado de las reflexiones sobre el lugar de la educación en estos tiempos de pandemia desde el rol del estudiante. La conversación se sitúa en las simetrías y asimetrías educativas en estos momentos de tensiones, crisis y novedades sociales, educativas, económicas y políticas por las que transita el ser humano. Se observa entonces que la educación ha cambiado y seguirá cambiando desde el espacio físico, las relaciones, los métodos de enseñanza, los currículos y las comunicaciones, lo que nos invita a centrar la mirada en la fragilidad de lo humano. Así las cosas, se propone abordar cuatro momentos; el primero contempla la relación entre sociedad y escuela; el segundo pregunta por el lugar de lo humano en la educación; el tercero invita a la reflexión en torno a la educación en tiempos de pandemia, como un asunto para seguir repensando, y el cuarto aborda la siguiente pregunta: ¿de qué escuela debemos empezar a hablar? Se reflexiona sobre saberes, prácticas y discursos que han venido concurriendo en el actual cambio de época y sobre las tensiones y dinámicas que afectan el acto educativo y, con ello, la experiencia humana.
Severe mycobacterium bovis BCG infection in an infant with partial dominant interferon gamma receptor deficiency-a case report
Authors: Reddy Jagruthi , Jose Priya , Varghese Mathew , Kumar Kommu Peter Prasanth
Published: October 2021

Mendalian susceptibity to mycobacterial disease (MSMD) is a condition caused by selective susceptibility to weakly virulent bacteria in otherwise healthy patients without additional immunological abnormalities. It is an inherited, genetic disorder with variety of clinical presentation. Diagnosis is mandatory because the illness may get precipitated by BCG and other live vaccines. Estimating interleukin in serum can be considered as a diagnostic test. Immunological analysis is mandatory for confirming the diagnosis. Mutation analysis can be done to confirm the mutation and hence, prevent the disease in the next sibling by testing in utero. This condition can be treated with ATT as the first line treatment. If ineffective, can be given other modalities of treatment described. But relapses are common. Stem cell transplantation is the definitive treatment. We describe an infant diagnosed as partial dominant interferon gamma receptor deficiency (IFNGR1) deficiency, who responded to ATT
Individualization of selection and training of female athletes in speed-power athletics from the perspective of gender identity
Authors: Vrublevskiy Eugeny , Skrypko Anatoly , Asienkiewicz Ryszard
Published: October 2021

Background and Study Aim. To develop and justify the criteria for morphogenetic markers of speed-power abilities of athletes and the main directions of individualization of the process of their preparation, taking into account the characteristics of the female body.
Material and Methods. Using the “2D: 4D” determination methodology, finger proportions were analysed for 126 qualified athletes specializing in speed-strength types (sprinting and hurdling, jumping, shot-putting) of different ages (from 17 to 25 years old). For 13 weeks, eight qualified short-distance student runners were regularly tested using computer strain gauge equipment: 5 masculine and 3 feminine types. The tensodynamograms of the manifestation of the strength of muscle groups carrying the main load in the structure of the sprint run were recorded and processed.
Results. It was found that 78% of the examined athletes observed finger proportions close to the "male" proportions. This may indicate their certain masculinization. The technique used for this can be an informative and simple marker to predict a genetic predisposition to the ability of effective performance of speed-power work. It was determined that the same amount of power load causes masculine athletes, runners for short distances, a more significant deployment of long-term adaptation restructuring of masculine athletes, runners for short distances, compared with athletes of a different gender identity.
Conclusions. Criteria for the prognostic assessment of speed-power abilities of athletes based on simple biological markers for testing and identification, like finger proportions (2D: 4D), have been developed. For athletes of high qualification who have a gender identity similar to men and a masculine somatotype, it is possible to use adapted male techniques for training.