bluuebunny/crossref_metadata_2025 huggingface dataset:
COSTS FOR THE SURGICAL TREATMENT OF OBESITY THROUGH LAPAROSCOPY IN A FEDERAL TERTIARY HOSPITAL BY THE BRAZILIAN UNIFIED HEALTH SYSTEM
Authors: FERRAZ Álvaro Antonio Bandeira , MEDEIROS Hiago Dantas , SANTA-CRUZ Fernando , KREIMER Flávio
Published: December 2024

ABSTRACT BACKGROUND: Obesity is a multifactorial disease affecting a significant portion of the population. Bariatric surgery emerges as a prominent approach in this context, representing an effective treatment both in the short and long term. The costs associated with bariatric surgery vary depending on the characteristics of the patients, current hospital practices, and available funding sources. AIMS: To analyze the costs of minimally invasive bariatric surgery for the treatment of obesity in a tertiary federal public hospital. METHODS: An observational and descriptive study aimed at assessing the costs associated with laparoscopic vertical gastrectomy (GV) and Roux-en-Y gastric bypass (RYGB) in a federal public tertiary service from 2018 to 2021. Data were obtained through the management of medical-hospital expenses related to surgical and anesthetic supplies, as well as the amount reimbursed by the funding source to the hospital. RESULTS: Over the analyzed period, a total of 177 minimally invasive bariatric surgeries were performed. In terms of the charges, since 2018, the hospital has been receiving an amount of R$ 6,145.00 for the “bariatric surgery by videolaparoscopy” procedure, which includes RYGB, and R$ 4,095.00 for “vertical gastrectomy.” Regarding the average hospital cost of surgical supplies, RYGB incurred a total of R$ 9,907.54, while GV incurred a total of R$ 9,315.84. The average total cost of RYGB was R$ 10,799.23, and, for GV, it was R$ 10,207.53. These figures indicate that the hospital incurred a loss of approximately R$ 4,654.23 for performing RYGB and R$ 6,112.53 for GV. CONCLUSION: Despite the increasing number of eligible patients for surgical treatment of obesity and the consequent quantitative growth of these procedures funded by the Brazilian Unified Health System (SUS), the costs exceed the reimbursement from the funding source in federal public hospitals. There is a need for a precise assessment of financing in the fight against obesity.
The Effect of Different Bleaching Techniques Using 6% Hydrogen Peroxide: Penetration Inside the Pulp Cavity, Bleaching Efficacy and Toxicity
Authors: Centenaro Gabrielle Gomes , Favoreto Michael Willian , Carneiro Taynara de Souza , Wendlinger Michel , Ferreira Christiane Philippini , Galvão Lívia Câmara de Carvalho , Loguercio Alessandro Dourado
Published: December 2024

Abstract This in vitro study aimed to quantify the penetration of hydrogen peroxide (HP), bleaching efficacy (BE) and toxicity in larvae in different bleaching techniques using 6% HP. Sixty maxillary premolars were divided in six groups (n = 10): Pola Luminate (PL), VivaStyle Paint On PIus (VS), PolaDay (PD), White Class (WC) and Whiteness HP Automixx (AM). A group not exposed to bleaching agents was evaluated as a control group (CG). Previously, the initial HP concentration in the bleaching agents was determined via titration and pH was measured with a digital pH meter. The concentration (µg/mL) of HP inside the pulp cavity was assessed using UV-Vis spectrophotometry. The BE (ΔE* ab and ΔE00) was evaluated with a digital spectrophotometer. The toxicity was evaluated in larvae model. Data from HP penetration and color change were evaluated for a one-way ANOVA and the Tukey’s test, as well as Kaplan-Meier death curve for toxicity (α = 0.05). VS, PD and AM had an initial concentration lower than that the manufacturers reported. VS had a more acidic pH. PL and WC showed a significantly lower HP amount inside the pulp cavity when compared to VS (p = 0.001). Regarding BE, no significant difference was observed for ΔE* ab (p = 0.38), and ΔE00 (p = 0.42). No toxicity was observed when all 6% HP was compared to GC (p > 0.05). All 6% HP products tested showed bleaching efficacy, low penetration into the pulp chamber and were non-toxic to Tenebrio molitor larvae.
Antimicrobial Effects of Cannabidiol (CBD)-infused Lozenges against Streptococcus mutans in Oral Health
Authors: Torabi Jila , Luis Henrique Pedro Soares , Mkrtchyan Gohar , Alavijeh Shohreh Derakhshan , Dezfoli Sameen , Hurlbutt Michelle
Published: December 2024

Abstract Cannabidiol presents several benefits, including but not limited to its analgesic, antioxidant, anti-inflammatory, antimicrobial, anti-pruritic, and anti-cancer properties. In this clinical trial, the antimicrobial impact of CBD-infused lozenges on Streptococcus mutans was examined using quantitative polymerized chain reaction (qPCR) bacterial analysis. This clinical trial involved 30 dental hygiene and nursing students who met the inclusion criteria participated in the study and were divided into two groups: experimental and control. The experimental group was given CBD-infused lozenges for 15 days, while the control group received sugar-free candy. Participants consumed one CBD-infused lozenge (300 mg) daily for 15 days, allowing it to dissolve slowly in the mouth for gradual absorption. The study focused on measuring changes in the salivary levels of Streptococcus mutans using quantitative polymerized chain reaction (qPCR) tests. Saliva samples were collected, and DNA extracted for qPCR analysis, assessing the bacterial load. The results, analyzed using a t-test, showed a significant decrease in Streptococcus mutans levels in the experimental group compared to the control group, with a statistically significant difference (p=0.0299).These findings suggest that cannabidiol may effectively reduce Streptococcus mutans in saliva, thus potentially helping to lower the risk of tooth decay as a multifactorial disease. This study underscores the potential of cannabidiol in enhancing oral health and calls for further research to explore its therapeutic applications in dental care.
Hygroscopicity of pectin-propolis films: sorption isotherms and thermodynamic properties
Authors: Veras July Maendra Lopes , Plácido Geovana Rocha , Romani Viviane Patrícia , Alves Jordana dos Santos , Sousa Tainara Leal de , Célia Juliana Aparecida , Oliveira Daniel Emanuel Cabral de , Monteiro Liliane Baldoino
Published: December 2024

ABSTRACT: Bio-based materials from proteins, polysaccharides, and lipids have been studied as biodegradable alternatives to synthetic plastics, as well as matrices for incorporation of bioactive substances. In this context, pectin is a polysaccharide used to produce flexible food packaging films. Propolis is a complex mixture of resinous substances with antimicrobial and other biological properties that can be used to generate active food packaging. However, the application of such materials is still limited due to their hydrophilic nature. Thus, this experimentally evaluated the sorption isotherms and isothermal heat of sorption of pectin-propolis films at temperatures of 15, 25, 30, and 35 °C, and determined the mathematical model that best fits the experimental data obtained. The pectin was extracted from pequi mesocarp, a widely consumed fruit in the Brazilian cerrado biome that generates large amounts of peels (exocarp and mesocarp) which are discarded. Among the mathematical models studied, the Sigma Copace model was found to best represent the hygroscopic behavior of the pectin-propolis films. The isothermal heat of sorption decreased with increasing water content, and the films presented similar behavior to agricultural products. The understanding of such film’s behavior contributed to the application of pectin-propolis films produced using pequi mesocarp as a pectin source.
Lean manufacturing in agriculture: benefits, obstacles, and opportunities
Authors: Carrijo Pâmella Rodrigues Silva , Batalha Mário Otávio
Published: December 2024

Abstract Lean manufacturing (LM) is a management philosophy focused on reducing waste while enhancing system productivity. Although its advancements have been more pronounced in the manufacturing sector, the benefits that LM are increasingly being recognized in other areas, including agriculture. Research on the application of LM in agriculture and livestock farming remains limited but has been gaining traction in recent years, as evidenced by the findings of this study. To contribute to the exploration of this emerging field, this article aims to map the current research landscape through a systematic literature review, supplemented by a content analysis. The SLR presented in this study had three main objectives: to identify which LM tools and techniques are most used in rural production, their benefits, and the elements that are central to their successful implementation. The research identified value stream mapping as the most widely used tool in rural production. The primary benefits observed were waste reduction and increased farm revenue. Successful implementation of LM in this context requires a five-step process, which is detailed in the paper.
Ações articuladas e política pública de inclusão de pessoas com deficiência no trabalho no município de São Carlos, São Paulo, Brasil
Authors: Simonelli Angela Paula , Navas Paula Márcia Gomes , Camarotto João Alberto , Jackson Filho José Marçal
Published: December 2024

Resumo Objetivo reportar a implementação de política para inclusão no trabalho de pessoas com deficiência (PCD), iniciada a partir de práticas de pesquisa e extensão acadêmicas para tratar da demanda colocada por algumas empresas a fim de atender à lei de cotas, em São Carlos – SP. Métodos relato de experiência organizado sob a forma de narrativa, fruto de análise documental e reflexão coletiva sobre intervenções após ações de extensão e de pesquisa e sobre participação na implementação de política pública. Resultados apresenta-se o desenvolvimento do “modelo de inclusão baseado na atividade” para inserir PCD em postos de trabalhos seguros e adaptados. Graças ao funcionamento em rede de atores sociais e institucionais, promoveu-se o “encontro de empresas e PCD”, fundando política pública municipal, implementada por meio do Projeto Ação, Trabalho e Oportunidade (ATO), entre 2008 e 2015. Participaram do projeto em média 40 PCD por ano; 85 pessoas foram empregadas; 61 empresas contrataram PCD no período. Conclusão São Carlos, reconhecida como polo tecnológico, foi “polo de inovação social e da inclusão de PCD” no período relatado, resultante do funcionamento da rede de serviços e da implementação de política pública original no Brasil.
Mental health agenda for business: an occasion for inquiring into individualized and individualizing measures
Authors: Ferretti Marcelo Galletti
Published: December 2024

Abstract Introduction the insufficient appeal by companies to individualized and individualizing measures, without any intervention in the organization of work, is ineffective as a way of mitigating the devastating effects of the COVID-19 pandemic on the mental health of workers and the population in general. Objective to recommend measures of a different nature for companies, guided by an expanded conception of clinical practice, the science of the psychosocial dimensions of the health-disease process, and the consideration of the socialization of suffering in workspaces. Methods literature review of important discoveries in Clinics of Work and the field of Work-Related Mental Health (WRMH). Results concepts such as weariness and the socialization of suffering are crucial for developing more effective forms of intervention, yet they are often overlooked in business environments. Conclusion this is a prime opportunity to inquire with companies about these aspects.
Big data em Saúde do Trabalhador: o quão distantes estamos?
Authors: Fagundes Thales Pardini , Wichmann Roberta Moreira , Silva Maria Eduarda de Lima e , Oliveira Tiago Almeida de
Published: December 2024

Resumo Objetivo identificar estratégias e desafios no uso de big data e inteligência artificial (IA) em saúde ocupacional, assim como práticas e obstáculos na sua implementação. Métodos revisão de escopo utilizando termos relacionados à saúde ocupacional, big data e IA em quatro bases de dados (Medline, Embase, BVS e SciELO), considerando artigos em português, espanhol e inglês publicados até 2022. Foram incluídos estudos com uso de grandes bases de dados e IA para análises relacionadas à saúde ocupacional. A seleção dos artigos foi feita independentemente por dois pesquisadores, com conflitos resolvidos por consenso. Resultados de 505 artigos identificados, 16 foram selecionados. O baixo número pode estar associado à escassez de dados que tratam da saúde do trabalhador de maneira sistêmica, considerando fatores demográficos, tecnológicos, socioeconômicos e ambientais. Os estudos selecionados mostraram que o big data e a IA têm bom potencial para subsidiar a saúde ocupacional ao identificar indicadores de saúde e possibilitar previsões precisas. A implementação enfrenta desafios, como armazenamento de dados e questões éticas. Conclusão big data e IA podem ser ferramentas úteis para analisar interações complexas de variáveis visando aprimorar a identificação de determinantes de saúde e dados de registros sobre ambientes de trabalho e indivíduos a eles expostos.
QUALIDADE NA EAD NA PERSPECTIVA ECOSSISTÊMICA
Authors: Ferreira Marcello , Ramos Wilsa Maria , Veloso Braian Garrito
Published: December 2024

RESUMO O objetivo deste ensaio é refletir acerca da noção de qualidade na educação a distância (EaD) no Brasil como objeto multiaxial, remontando aspectos de sua historiografia e das relações com ideais de constituição da evolução societal a partir das mediações interativas de base tecnológica e produtiva. A proposta se inscreve em perspectiva epistemológica crítica, perpassando a ressignificação de indicadores transeuntes da preponderância da economia de larga escala e signatários dos modelos avaliativos internacionais, com vistas a novas perspectivas éticas e estéticas. Ao final, propõe-se uma nova “matriz-qualidade para a EaD”, fundamentada na integração entre desenvolvimento humano e ecossistemas de aprendizagem potentes nessa modalidade.
Occurrence of Leishmania spp. DNA and specific antibodies in dogs from Acre State, Rio Branco, Brazil
Authors: Bento Gleice Kelly Carvalho , Zanfagnini Leticia Gomes , Laurenti Marcia Dalastra , Tomokane Thayse Yumie , Matta Vania Lucia Ribeiro da , Souza Soraia Figueiredo , Pacheco Acácio Duarte
Published: December 2024

Abstract Canine leishmaniasis is a parasitic disease whose agents are transmitted through the bites of infected phlebotomine sand flies. This disease is endemic in tropical and subtropical regions, including Brazil. However, information on its prevalence in dogs in some Brazilian states remains limited. This study aimed to assess the seroprevalence of canine leishmaniasis in Rio Branco, Brazil. Blood samples were collected from 375 dogs aged > 6 months. Two distinct serological methods, dual path platform test (DPP) and enzyme linked immunosorbent assay (ELISA), were used to investigate the occurrence of anti-Leishmania spp. antibodies. The results showed a seroprevalence of 38.1%, indicating that the disease occurred in this region. Blood samples considered positive in at least one of the serological methods were subjected to conventional polymerase chain reaction (PCR), which confirmed the presence of infection in 28.3% (106/375) of the total samples. This is the first study to provide detailed information on the seroprevalence of canine leishmaniasis in dogs in Rio Branco, highlighting the importance of disease surveillance and control. Effective actions, such as education campaigns on sand fly prevention and control measures, are necessary to reduce the occurrence of canine and human leishmaniasis in cities.
Educational Leadership in Wales Since Devolution
Authors: Griffiths Jeremy , Jones Gethin
Published: December 2024

This article examines the evolution of educational leadership in Wales since devolution, highlighting key developments, challenges, and reforms. Despite a slow start in adopting leadership as a policy driver, Wales has made significant strides in recent years, recognising leadership’s crucial role in pupil outcomes. Political and ministerial leadership styles have varied, influencing major educational reforms such as the Foundation Phase and the Curriculum for Wales. The impact of international assessments like PISA, alongside OECD reviews, has underscored the need for effective leadership at all levels. Initiatives like the National Academy for Educational Leadership and the new Professional Standards for Teaching and Leadership reflect Wales’ commitment to fostering educational leadership. However, challenges persist, including recruitment and retention issues, workload concerns, and the lingering effects of the COVID-19 pandemic. This article advocates for a proactive approach to leadership development, emphasising professional learning, support systems, and a cultural shift to elevate the status of educational leaders. By building on past achievements and addressing current challenges, Wales can ensure sustainable educational improvement and a vibrant learning environment for all students.
Az additív gyártás során alkalmazott szálerősített kompozitok katonai alkalmazásának lehetőségei
Authors: Daruka Norbert , Dénes Kálmán , Ember István , Kovács Zoltán , Vég Róbert
Published: December 2024

Minden rohamosan fejlődő technológia megérdemli a kiemelt figyelmet a katonai alkalmazás területén, különösen akkor, ha már bizonyított is a mindennapok során. Az additív gyártás ilyen technológia, alkalmazása már a háztartások számára is elérhető. A speciális alapanyagok, mint a szálerősített polimerek azonban különösen érdemesek a vizsgálatokra. Írásunkban ezt a vizsgálati irányt elemezzük katonai szempontok szerint, figyelembe véve a speciális igényeket. Sikerült meghatároznunk és rendszereznünk ezeknek az anyagoknak az alkalmazási lehetőségeit a katonai körülményekhez igazítottan.
The structural relationship between social realism of YouTube tourism content and tourism behavior intention: Application of the AIDA model
Authors:   The Tourism Sciences Society Of Korea, Chung Jellna , Kwon Ki-Joon
Published: December 2024

This study examines the influence of YouTube tourism content on the decision-making processes of those who have watched such content. In doing so, this study applies the AIDA model, which has not been considered in previous studies. An online survey was conducted targeting Korean adults who have watched YouTube content introducing travel and tourist destinations in the past 12 months. SPSS and AMOS statistical programs were used to analyze the survey data and the results demonstrate the following. Firstly, the social realism of YouTube tourism content had a positive influence on interest and immersion in tourist destinations. Second, interest and immersion positively influenced the desire to visit the destination. Third, desire also positively influenced both the intention to visit and the intention to continue watching YouTube tourism content. These findings provide a deeper understanding of the marketing effectiveness of YouTube tourism content and provide useful implications for formulating digital media-based marketing strategies to promote tourism consumption.
The impact of perceptions of airline mergers and acquisitions on job stress, burnout, and turnover intentions among cabin crew of acquired airlines
Authors:   The Tourism Sciences Society Of Korea, Kang Ye-Lim , Yoon Ji-Hwan
Published: December 2024

This study aims to investigate the impact of employment insecurity perceived by flight attendants at the acquired airline, along with perceptions of fairness, on job stress, job burnout, and turnover intention, within the context of Korea's first-ever merger between major full-service carriers. Initiated with the need to examine the psychological health of flight attendants amidst this prolonged merger process, the study specifically analyzes how prolonged integration affects job burnout and turnover intention among acquired airline employees. The results reveal that employment insecurity significantly increases job stress and burnout, while procedural, distributive, and interactional fairness perceptions were found not to significantly impact job stress. However, interactional fairness helps reduce job burnout, and both job stress and burnout were found to significantly increase turnover intention. These findings underscore the importance for the acquiring airline to enhance communication and provide stability assurances to alleviate job insecurity and mitigate job stress and burnout among flight attendants at the acquired airline. Through these measures, the airline may be able to reduce turnover intentions and promote the psychological well-being of its staff.
A Grounded theory study on leisure constraints experienced among working mothers with young children
Authors:   The Tourism Sciences Society Of Korea, Kim Sung-Min
Published: December 2024

This study aims to comprehensively approach and understand the leisure activity experiences of working mothers with infants or toddlers, focusing on the changes and challenges that occur in their leisure time during the period of childbirth and caregiving. The sample for this study consisted of working mothers with infants and toddlers (under six years old), selected through theoretical sampling based on previous research. Data were collected from 14 participants through in-depth interviews, and the collected data underwent continuous expert review throughout the analysis process. Content analysis revealed 133 concepts, 31 subcategories, and 10 supercategories, leading to the development of a paradigm model. The causal conditions identified were 'absolute leisure constraints' and 'emotional changes after childbirth,' with the contextual condition being 'roles assigned in modern society.' The central phenomena were identified as 'expansion of passive leisure activities' and 'children's leisure activities becoming my leisure activities,' while the mediating condition was 'tolerance of leisure constraints.' The action/interaction strategies were 'leisure constraint negotiation' and 'changes in leisure activities,' leading to outcomes of 'second identity formation' and 'acceptance.' The core category of selective coding was defined as 'transition from a new mother to a true mother.' This study provides theoretical implications as a foundational analysis of the leisure constraints and experiences encountered by mothers of young children, as well as policy and practical implications that can inform the development of leisure policies aimed at encouraging childbirth among mothers with young children.
Analysis of preferred decent job types as subjectively perceived by tourism management students: Application of Q methodology
Authors:   The Tourism Sciences Society Of Korea, Cha Suk-Bin
Published: December 2024

Although the employment environment is challenging, students' interest in decent jobs is growing. This study applied Q methodology to analyze the preferred types of decent jobs, a topic previously unexplored in the tourism sector, as subjectively perceived by university students majoring in tourism management. Thirty nine statements were selected as the Q sample derived from a literature review and in-depth interviews with professors and students. Factor analysis of 39 fourth-year students identified four distinct types of decent jobs: stress avoidance(Type 1), self-development through demonstrating abilities(Type 2), emphasis on promotion and performance compensation(Type 3), and wage orientation(Type 4). Type 1 preferred ‘work that is less stressful and allows them to relax both physically and mentally’, while Type 2 preferred ‘jobs with great potential for my development’ and ‘jobs where I can demonstrate my abilities.’ Type 3 favored ‘jobs with a high possibility of promotion’ and ‘jobs where compensation such as incentives is given appropriately based on performance’ whereas Type 4 prioritized ‘high wages’. The findings suggest that when professors provide employment guidance to graduating students, tailored approaches are needed based on the four types of decent jobs identified. The study highlights theoretical contributions and practical implications and proposes directions for future research.
A gyermek művészeti nevelését befolyásoló tényezők a szülők szemszögéből
Authors: Kiss Julianna , Bartalis Izabella , Kerekes Rita
Published: December 2024

In this study, we analyzed the musical activities of their children based on the answers from the 458 parents participating in the research. We tried to discover how imporant was to the parents for their children to study music, and for what reasons they picked a particular field of music. We also inquired into the kinds of effects the music education had on their children. We examined the correlations of the three forms of cultural capital with the children's participation in music education. We were also looking for correlations between the parents' artistic activities (musical activities, playing instruments) and their children's participation in music education. In addition to descriptive statistical procedures, the data was analyzed using factor analysis and cross-tabulation analysis.
Epidemiological survey on prevalence and subtypes distribution of Blastocystis sp. in Southern Guizhou, China
Authors: Fu Xiaoyin , Lyu Jiayin , Shi Yunliang , Cao Bingying , Liu Dengyu , Yang Xi , Huang Lin , Liang Qiuguo , Liao Dejun , He Shanshan
Published: December 2024

Blastocystis sp. is one of the most common intestinal protozoan parasites of humans worldwide and often has genetic polymorphisms. Due to its high prevalence and the possibility of potential transmission to humans, this study was carried out to investigate the prevalence of Blastocystis sp. and characterize its subtypes (genotypes) in southern Guizhou, China. A total of 548 fecal samples were collected from hospital patients for culture-based diagnosis. PCR products were sequenced and phylogenetically analyzed to identify subtypes and analyze their distribution. 43 positive cases of infection with Blastocystis sp. were detected, resulting in an overall prevalence of 7.85% (43/548). Seven subtypes were identified: ST3 (55.81%), ST1 (25.58%), ST7 (6.98%), ST5 (4.65%), ST2 (2.33%), ST4 (2.33%), and ST15 (2.33%). ST3 demonstrated the lowest intra-ST diversity, followed by ST1. Blastocystis sp. infection in southern Guizhou was caused by seven subtypes (ST1–ST5, ST7 and ST15) of the parasite, in which ST3 was the most common subtype, followed by ST1. The lowest intra-ST diversity of ST3 may be associated with substantial interhuman transmission in Guizhou. ST15 was found for the first time in humans, suggesting that it has the potential to be a zoonotic parasite. These findings have enhanced our understanding of the epidemiology and transmission of Blastocystis sp. in Southern Guizhou, China.
Unconventional Nature of Value
Authors:   Lomonosov Moscow State University (Moscow)., Varkhotov Taras
Published: December 2024

The article is devoted to the revision of the theory of values. Transcendental and
socio-psychological interpretations of value are consistently considered. From the standpoint
of phenomenological analysis, it is noted that values are understood as unconditional ultimate
goals that have non-conventional normativity: something is a value not because an appropriate
agreement was reached, but the agreement became possible because it is based on the gut feeling
of value. It is shown that transcendental theories of value, developed within the framework of
neo-Kantianism and other neoclassical philosophical movements, were supplanted by empirically
oriented positivist theories of value due to the inability to offer an effective methodological
program and, accordingly, to provide an explanation compatible with the standards of scientific
knowledge for the historical diversity of cultural value systems despite the declared universalism
of values. At the same time, an attempt to understand values within the framework of empirical
approaches – as historical conventions based on the sociobiological human nature – led to the
replacement of the study of values with the study of opinions about values. Although this
approach fits well with the prevailing constructivist trend in the development of the methodology
of the social sciences and humanities, it diverges from the phenomenology of value, since
unconditionality and non-conventionality constitute the intuitive semantic core of this concept.
The identification of value as a universal vector and the interpretation of value as the sociohistorical
implementation of this vector leads to confusion and loss of the research subject. In
extreme forms, this is expressed either in the dissolution of the value in the political and in the
recognition of rational conventions as universally normative, or in libertarianism. Therefore, the
starting premise for any study of values should be the distinction between conventions as a result
of the interpretation of values and the values themselves, the non-conventionality of which is the
only stable invariant of all existing conventions in this area.
La Historia del currículum como fuente para la Didáctica de las Ciencias Sociales
Authors: Romero Morante Jesús
Published: December 2024

In this article, the sociogenetic analysis of the curriculum is defended as an essential tool to objectify and denaturalize one's socialization in school culture and subject subcultures; and, in particular, to challenge the spontaneous ideologies that essentialize the knowledge given in the classrooms. The "historicization" of teacher practice and thinking can provide the necessary distance to make our experience strange. And such distancing is one of the conditions to make possible an innovation and a teacher education genuinely aimed at improving the teaching and learning of the social.
ht-HiTE: High-Throughput DNA extraction from FFPE tissue v2
Authors: Geisenberger Christoph
Published: December 2024

This protocols outlines a high-throughput method for DNA extraction from FFPE material. The workflow has been automated on a Biomek i5 platform. 1 to 2 tissue scrolls (10 µm) or tissue macrodissected from glass slides is used as input and eluted in 60 µl after nucleic acid purification. Mean and median yield is 86.6 and 72.0 ng/µl (equivalent to 4.3 to 5.3 µg of total DNA).
16S Data Analysis Protocol v1
Authors: McLean Paul
Published: December 2024

Learn how to upload sequence data into BV-BRC and analyze the results.
Proteomics sample preparation v1
Authors: Vitale Tevis , Liang Jiaxin , Puigserver Pere
Published: December 2024

Protocol for proteomic analysis and data acquisition used in: "Selective Deficiency of MitochondrialRespiratory Complex I Subunits Ndufs4/6 Causes Tumor Immunogenicity". The paper's abstract is as follows: Cancer cells frequently rewire their metabolism to support proliferation and evade immune surveillance, but little is known about metabolic targets that could increase immune surveillance. Here we show a specific means of mitochondrial respiratory Complex I (CI) inhibition that improves tumor immunogenicity and sensitivity to immune checkpoint blockade (ICB). Targeted genetic deletion of either Ndufs4 or Ndufs6, but not other CI subunits, induces an immune-dependent growth attenuation in melanoma and breast cancer models. We show that deletion of Ndufs4 induces expression of the MHC class-I co-activator Nlrc5 and antigen presentation machinery components, most notably H2-K1. This induction of MHC-related genes is driven by a pyruvate dehydrogenase-dependent accumulation of mitochondrial acetyl-CoA, which leads to an increase in histone H3K27-acetylation within the Nlrc5 and H2-K1 promoters. Taken together, this work shows that selective CI inhibition restricts tumor growth, and that specific targeting of Ndufs4 or Ndufs6, increases T-cell surveillance and ICB responsiveness.
Cross mapping of self-care interventions for expert patients
Authors:   Universidade Federal do Rio Grande do Norte, dos Santos Bezerril Manacés , Barreto Tavares Chiavone Flávia ,   Universidade Federal do Rio Grande do Norte, Cunha da Silva Larissa Arielly ,   Universidade Federal do Rio Grande do Norte, Fernandes Costa Isabelle Katherinne ,   Universidade Federal do Rio Grande do Norte, Sánchez Ayllón Francisca ,   Universidade Federal do Rio Grande do Norte, Vázquez Santiago Maria Soledad ,   Universidade Federal do Rio Grande do Norte, Campos de Azevedo Isabelle ,   Universidade Federal do Rio Grande do Norte, Pereira Santos Viviane Euzébia ,   Universidade Federal do Rio Grande do Norte
Published: December 2024

Objective. To compare the primary nursing interventions described in the literature to promote self-care among expert patients with the Nursing Interventions Classification.

Methods. This descriptive and exploratory study used a quantitative approach and cross-mapping focusing on 23 self-care actions obtained from a scoping review conducted in January 2022 in Brazilian and international databases. Data were descriptively analyzed, processed, and presented in tables.

Results. Twenty-three self-care actions were found in the scoping review. A total of 56 interventions were selected, 30 of which were associated with self-care actions; some were associated with more than one intervention (e.g., physical activity, avoiding alcohol consumption, blood glucose monitoring, blood sugar management, stress/anxiety).

Conclusion. The self-care interventions promoted among expert patients were compared to the Nursing Interventions Classification, enabling nurses to lead by encouraging, assisting, teaching, discussing, and guiding patients. Hence, nursing workers can improve their work process by encouraging patient self-care and autonomy in the health-illness continuum.
The Impact of a Catalytic Site Mutation on the Shape and Mechanics of Tubulin Protofilaments
Authors: Fedorov V.A. , Kovalenko I.B.
Published: December 2024

Alpha-beta heterodimers of tubulin proteins serve as the building blocks of microtubules, which are key biopolymers forming one of the principal systems of the cellular cytoskeleton. A detailed study of these building blocks, as well as their alterations caused by point mutations, contributes to a deeper understanding of physiological and pathological processes related to the cytoskeleton. This study presents an analysis of the impact of the E254N point mutation in the catalytic site of α-tubulin on the bending conformations of human recombinant tubulin tetramers using molecular dynamics methods. The models were constructed based on high-resolution cryo-electron microscopy data, allowing the reconstruction of three-dimensional structures of both wild-type and mutant tetramers. The simulations revealed that the primary difference between wild-type and mutant tubulin lies in the equilibrium bending direction of the protofilaments, while the bending amplitude, twisting, and associated stiffness remain largely unchanged. We propose that the observed differences in bending directions may be related to variations in protofilament tilts within microtubules, which aligns with previously published cryo-electron microscopy data. These findings provide valuable insights into the principles underlying the formation of the polymeric structure of microtubules based on the properties of their individual building blocks.
Deep Learning-Assisted Design of de novo Protein Binders Targeting Hepatitis C Virus E2 Protein
Authors: Al-Hayani Noor N. , Mohaisen Mohammed R. , Rashid Sara A.A.
Published: December 2024

Hepatitis C virus is a grievous disease with an increased mortality rate worldwide. Chemical-based medications possess deleterious side effects and are considered inefficient in combating viral infections. Advanced therapeutic strategies are being examined with increased specificity against viral proteins such as designing highly regular proteins facilitating the development of highly effective inhibitors. Here, we present for the first time, the use of deep learning-based large language protein model ProtGPT2 with a unique strategy to design novel therapeutic binders that have the potential to mimic host receptors and inhibit the viral protein, especially the HCV envelope glycoprotein E2 for clinically relevant genotype 1a and 1b. We generated five de novo proteins for each host receptor that mimic the human receptors, based on the interacting residues which were identified by the tools of the PDBSum database in the docked host-E2 complexes generated with the ClusPro web server. The Root Mean Square Deviation score revealed that each de novo designed binder exhibited high similarity with the human receptors indicating a successful generation. Furthermore, multiple interactions were observed between these de novo designed proteins and E2 protein, emphasizing the potential of these de novo designed proteins as significant inhibitors. A comparative analysis of molecular docking between human interacting partners and de novo designed proteins revealed that de novo proteins, such as CD81-D1 and CLDN-D4, are the most effective inhibitors having the lowest binding energy when interacting with the most conserved regions of the E2 protein. These generated proteins may inhibit the interaction of E2 with CD81 and CLDN host receptors.
Field validation of country-wide remote sensing based-land use classification in Kyrgyzstan
Authors: Başsüllü Çağlar , Martín-ortega Pablo
Published: December 2024

Observing and monitoring land use, land-use change and forestry (LULUCF) trends has extensively been used remote sensing. Collect Earth, a free remote sensing tool, was used in Kyrgyzstan to assess the historical and present LULUCF trends in 2015 and 2019. However, it is quite difficult for users to classify land cover and determine changes in land use if no satellite images with sufficient temporal and spatial resolution are available. The unavailability of high/very high spatial and temporal resolution satellite images (7.2%) or the availability of low spatial and temporal resolution satellite images (7.8%) was the primary reason for mandatory field verification. A fieldwork was conducted to validate the remote sensing assessment in 2019. In total, 941 sample plots were visited, and 119 misclassified sample plots were detected during the field validation work. Hence, this article reports an updated version of LULUCF assessment in Kyrgyzstan. The database update resulted in the re-classification of 1073 sample plots in Kyrgyzstan. The results of the field validation showed that forestlands occupied 1.81 million ha (9%) of the total land in 2019, with a 5.33% uncertainty in Kyrgyzstan. However, it was 1.36 million ha based on the remote sensing study.
Exploring Crystal Methamphetamine Use Among School-Going Learners: A Qualitative Case Study in South African Schools
Authors: Singwane Thembinkosi Peter , Ramoshaa Dillo Justin
Published: December 2024

The increasing prevalence of drug use in schools poses significant challenges for educational environments and society at large. Persistent substance abuse among students is linked to various negative outcomes, including poor academic performance, strained relationships, physical injuries, violence, heightened sexual activity, and suicidal ideation. This qualitative study employed a multiple case study design to investigate crystal methamphetamine use among community members and learners in selected schools in Polokwane, South Africa. Data were collected through semi-structured interviews, which provided rich insights into the experiences of school-going learners regarding crystal meth use. The findings reveal that learners who engage in crystal meth use experience considerable declines in both physical and mental health. Many participants reported noticeable physical changes, such as significant weight loss. Additionally, the study identified adverse behavioural changes among these learners; they often exhibited disruptive behaviour and a lack of respect towards teachers, further complicating classroom dynamics. These results underscore the urgent need for targeted interventions to address substance abuse in educational settings and promote healthier behaviours among students.
Integrating Sustainability into Curricula: A Systematic Review of Education for Sustainable Development
Authors: Wan Nor Azmi Wan Norsyafiqah Arinah , Abd Wahid Nur Husna , Syed Azman Sharifah Maryam , Jayus Rozita
Published: December 2024

Integrating sustainability into curricula is crucial for preparing students to address global environmental challenges. This systematic literature review, conducted using the PRISMA methodology, focuses on identifying effective pedagogical strategies for integrating sustainability into curricula and examines their impacts on students' learning outcomes. By analyzing 28 articles published between 2019 and 2024, the review highlights key pedagogical strategies such as problem-based learning, project-based learning, and service learning. These approaches are applied across various educational levels, including school, pre-university, and university settings. Additionally, it highlights the impacts of these integrations on students' learning outcomes, including the development of Education for Sustainable Development (ESD) competencies, fostering sustainability literacy, fostering global citizenship, and preparing students for sustainability-related careers. These findings provide valuable insights for educators and institutions aiming to effectively integrate sustainability into education, thereby equipping students with the necessary skills and knowledge to tackle global environmental challenges and contribute to a sustainable future.
Phonological Analysis of Syllabic Changes of Arabic Loan Verbs
Authors: Mawaridi Muhaimin Syaqiq , Mohamad Isa Abdul Azim , Hassan Lutfi
Published: December 2024

The original form of a language is often changed when the language is borrowed into the target language. In Malay, one of the changes that can be observed is the reduction of syllable segments. The change results from integrating and adapting the source language to the target language for native-like adaptation. Therefore, this study investigates the reduction of syllable segments and phonological changes of syllable segments in Arabic loan verbs. The reduction of syllable segments refers to a segmental reduction in the first, second or third syllable. The phonological change of the syllable segment refers to the sound change that occurs when the syllable segment is reduced. This study uses Arabic loan verbs in Kamus Dewan Perdana as research data. The collected data was transcribed and 30 Arabic loanwords were found to have syllable segment reduction. The data is then analysed using the theory of sound change to determine the phonological changes that occur in the syllable segments in the Arabic loanwords. The study results show that there are 3 types of segmental reduction located in the first syllable, 26 verbs in the second syllable and 3 verbs in the third syllable. In addition, the study's results also show that phonological changes for syllable segments in Arabic loanwords occur through vowel adaptation, neutralization and scramble. These changes generally take the form of vowel adjustments that shorten the vowel sound of the original Arabic spelling, which accounts for most of the sound changes in syllable segment reduction.
Reasonable Accommodation, Career Development, and Psychological Well-being: Autoethnography as a Method of Qualitative Research
Authors: Gulyamova Saodat , Manap Jamiah , Aizan Sofia , Omar Nik Hairi
Published: December 2024

: Individuals with health issues and disabilities tend to encounter difficulties in the workplace, including decreased productivity and lower job performance compared to those without such problems. Nevertheless, creating a workplace environment that accommodates individuals with disabilities can help them overcome workplace obstacles and fulfil their job duties at the same level as disability-free individuals. Providing reasonable accommodation is one practical step in establishing an inclusive environment for those with vision impairments, leading to career development and psychological well-being. This paper focuses on workplace-related autoethnographic stories to explore the fundamental aspects of reasonable accommodation, career development, and psychological well-being for individuals with vision impairments. This study employed the method of autoethnography in qualitative research. Autoethnographic data was collected through personal reflection and the collection of relevant artefacts. Thematic analysis was used for the data analysis procedure. Therefore, having a disability does not necessarily mean an individual cannot do their job to the necessary standard. Visually impaired individuals can excel in their careers and attain psychological well-being when they are part of a workplace environment that is accommodating to their needs. To enhance job performance, career goals, and psychological well-being among employed disabled individuals, it is necessary to define "reasonable accommodation" in the Law of the Republic of Uzbekistan on the Rights of Persons with Disabilities, based on the UN Convention.
Evaluating Dialogic Communication of Pesantren in East Java, Indonesia: Building Public Relationships via Instagram
Authors: Luthfi Mohammad , Tengku Mohd Azzman Shariffadeen Tengku Siti Aisha , Utomo Bambang Setyo , Rukmini Diah , Husen Ryan Maulana
Published: December 2024

Instagram posts by pesantren are very high but replies and reactions to followers' comments are still very low, as an indicator that communication between pesantren and their public is not a two-way dialogue. This study aims to evaluate dialogic communication of pesantren in East Java, Indonesia in building public relationships via Instagram. A quantitative approach with content analysis methods is used to measure dialogic communication of pesantren on Instagram with four principles, namely the information of interest to public, the generation of return visits, the conservation of visitors and the dialogic loop. The sample was determined using purposive sampling by identifying and verifying official Instagram accounts of pesantren that had a minimum of 15 posts on June and 15 posts on July 2023. Data analysis used frequency distribution to exmine the frequency of posts. Results indicated that most of pesantren have implemented dialogic communications in building public relationships on Instagram optimally. The principle of information of interest to publics and the principle of generation of return visits are most commonly used with a very high category. The principle of conservation of visitors is low category and the principle of dialogic loop is very low category implemented. The implication of this study can provide the theoretical contribution and strategic implication on implementation the dialogic communication to build public relationships through Instagram. With a lack of study done in this area, the novelty of this study is in extending understanding on the use of dialogic communication of pesantren, especially in East Java, in building public relationships on Instagram.