bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxicity alleviation for microalgae cultivation by cationic starch addition and ammonia stripping and study on the cost assessment
Authors: Li Jun , Wang Lin , Lu Qian , Zhou Wenguang
Published: November 2019

Aiming at promoting microalgae-based anaerobically digested swine manure (AD-SM) treatment, this work evaluated the feasibility of removing turbidity and ammonia in swine manure by cationic starch addition and air bubbling-driven ammonia stripping.
New dimensions in calix[4]pyrrole: the land of opportunity in supramolecular chemistry
Authors: Rather Ishfaq Ahmad , Wagay Shafieq Ahmad , Hasnain Md Saquib , Ali Rashid
Published: November 2019

The quest for receptors endowed with the selective complexation and detection of negatively charged species continues to receive substantial consideration within the scientific community worldwide.
The phase diagram of colloidal silica–PNIPAm core–shell nanogels
Authors: Frenzel Lara , Lehmkühler Felix , Koof Michael , Lokteva Irina , Grübel Gerhard
Published: November 2019

We study the structure and dynamics of aqueous dispersions of densely packed core–shell nanoparticles composed of a silica core and a poly(N-isoproylacrylamide) (PNIPAm) shell as a function of temperature and concentration.
Conformational dynamics and phase behavior of lipid vesicles in a precisely controlled extensional flow
Authors: Kumar Dinesh , Richter Channing M. , Schroeder Charles M.
Published: November 2019

Direct observation of vesicle conformational dynamics in extensional flow and precise characterization of flow phase diagrams using a Stokes trap.
Gal-3 is a potential biomarker for spinal cord injury and Gal-3 deficiency attenuates neuroinflammation through ROS/TXNIP/NLRP3 signaling pathway
Authors: Ren Zhouliang , Liang Weidong , Sheng Jun , Xun Chuanhui , Xu Tao , Cao Rui , Sheng Weibin
Published: November 2019

Spinal cord injury (SCI) often occurs in young and middle-aged population. The present study aimed to clarify the function of Galectin-3 (Gal-3) in neuroinflammation of SCI. Sprague–Dawley (SD) rat models with SCI were established in vivo. PC12 cell model in vitro was induced by lipopolysaccharide (LPS). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Gene chip were used to analyze the expression levels of genes in the signaling pathway. Histological assessment, ELISA and Western blotting were conducted to evaluate the effects of Gal-3 upon the SCI model. In the in vivo SD rat model, Gal-3 expression level was up-regulated. The inhibition of Gal-3 attenuated the neuroinflammation in SCI model. The inhibition of Gal-3 could also mitigate the neuroinflammation and reactive oxygen species (ROS) in in vitro model. ROS reduced the effect of Gal-3 on oxidative stress in in vitro model. Down-regulating the content of TXNIP decreased the effect of Gal-3 on neuroinflammation in in vitro model. Suppressing the level of NLRP3 could weaken the effect of Gal-3 on neuroinflammation in in vitro model. Our data highlight that the Gal-3 plays a vital role in regulating the severity of neuroinflammation of SCI by enhancing the activation of ROS/TXNIP/NLRP3 signaling pathway. In addition, inflammasome/IL-1β production probably acts as the therapeutic target in SCI.
Spectral modeling of type II supernovae
Authors: Vogl C. , Kerzendorf W. E. , Sim S. A. , Noebauer U. M. , Lietzau S. , Hillebrandt W.
Published: November 2019

There are now hundreds of publicly available supernova spectral time series. Radiative transfer modeling of this data provides insight into the physical properties of these explosions, such as the composition, the density structure, and the intrinsic luminosity, which is invaluable for understanding the supernova progenitors, the explosion mechanism, and for constraining the supernova distance. However, a detailed parameter study of the available data has been out of reach due to the high dimensionality of the problem coupled with the still significant computational expense. We tackle this issue through the use of machine-learning emulators, which are algorithms for high-dimensional interpolation. These use a pre-calculated training dataset to mimic the output of a complex code but with run times that are orders of magnitude shorter. We present the application of such an emulator to synthetic type II supernova spectra generated with the TARDIS radiative transfer code. The results show that with a relatively small training set of 780 spectra we can generate emulated spectra with interpolation uncertainties of less than one percent. We demonstrate the utility of this method by automatic spectral fitting of two well-known type IIP supernovae; as an exemplary application, we determine the supernova distances from the spectral fits using the tailored-expanding-photosphere method. We compare our results to previous studies and find good agreement. This suggests that emulation of TARDIS spectra can likely be used to perform automatic and detailed analysis of many transient classes putting the analysis of large data repositories within reach.
The informativeness of roof tremor hazard analysis based on seismic measurements and analytical modelling
Authors: Chlebowski Dariusz , Burtan Zbigniew
Published: November 2019

Rock bursts are a common hazard in Polish hard-coal mines. Their magnitude depends on the state of stress in the mining area, and on underground mining-induced seismicity. Both long-term and ongoing as-sessments of the capacity of the rock mass to generate tremors are based on geological and mining surveys, rock property measurements (in laborato-ries and in-situ) and observations involving signs of rock mass pressure, supported by available concepts applicable to geomechanical and geophys-ical measurements. These include seismic measurements, including profil-ing, scanning, passive/active geotomography and analytical techniques. This paper presents a comparative analysis involving exemplary results provided by both seismic and analytical methods for a selected panel in one of Upper Silesian Coal Basin (USCB) mines. For the purposes of our seismic measurements, we employed seismic tomography for the ge-otomographic reconstruction of velocity fields. Subsequently, we com-pared the results with the results of analytical modelling of rock stresses that relied on classical engineering solutions applicable to problems of me-chanics of deformable bodies. The tremor hazard analysis was based on observations of changes in P-wave velocity distributions in the coal seam environment relative to the evolution of the vertical stress concentration factor at the level of a potentially seismogenic roof layer.
Analysis of the displacement of road embankments and bridges located in areas prone to landslides
Authors: Pilecka Elżbieta , Tomaszkiewicz Karolina
Published: November 2019

Landslides are a common problem in road engineering. Therefore, at the stage of designing new roads, it is preferable to design them in such a way as to avoid as many landslide areas as possible. In the case of existing roads running through landslide areas, one of the solutions designed to eliminate road embankment damage caused by landslide movement is to divert traffic over the landslide using a bridge structure. The article presents the results of monitoring road embankments located in a landslide prone location and a bridge, which serves to divert the voivodeship road over the active landslide. The measurements were carried out using a terrestrial laser scanner. The differential model obtained during data analysis allowed for the determination of the area and size of deformation in the analyzed area.
Feeding inhibition tests as a tool for seston quality evaluation in lentic ecosystems: salinization impact
Authors: Queirós Vanessa , Azeiteiro Ulisses Miranda , Antunes Sara Cristina
Published: November 2019

Environmental disturbance on freshwater ecosystems significantly impacts all levels of the trophic web. Salinity in lentic freshwater ecosystems, as a consequence of climatic changes, is rising concern in the scientific community. These alterations affect water quality, the composition and diversity of the aquatic communities. This study aimed to assess the seston quality of two lentic ecosystems, Crestuma reservoir and lake Vela, and evaluate the effects of salinity on food performance of Daphnia magna and Daphnia longispina (isolated from the referred ecosystems). Feeding inhibition tests were used to conduct these two evaluations. Physical and chemical water classification revealed a poor or good ecological potential of the two lentic ecosystems, according to WFD approach. To evaluate seston quality, filtered and unfiltered water samples from the lentic ecosystems were used as treatments. Although only summer samples from Crestuma presented good water quality, the results from the feeding inhibition tests showed that seston from lake Vela presented more nutritional quality. Concerning the assay to evaluate the salinity effect on Daphnia spp., a significant reduction in the filtration rate was observed. The NOEC value was 0.7 g/L NaCl and 0.8 g/L NaCl for D. magna and D. longispina C and V, respectively. The LOEC value was also distinct between species, being 1.0 g/L and 0.9 g/L, respectively. This work allowed to verify that feeding inhibition tests are not sensitive enough for assess the quality of natural waters. However, these tests are economically viable and have high sensitivity to evaluate NaCl effects on Daphnia spp.
La reconstitution quasi exacte du grand diamant bleu de Louis XIV
Authors: Farges François
Published: November 2019

Les minéraux – et plus particulièrement les gemmes – ont été les instruments de pouvoir privilégiés des souverains du passé. Entre vols, ventes et autres aliénations, la majorité de ces chefs-d’œuvre de l’art lapidaire n’ont pas survécu. La science – qu’elle soit histoire de l’art ou physique des géomatériaux – nous aide à les restituer de manière rigoureuse.

Ainsi, la spectroscopie optique quantitative permet de reconstituer exactement le fabuleux diamant bleu de Louis XIV, qui avait été volé en 1792 sans laisser de traces évidentes. Des nanotechnologies permettent même de recréer une réplique exacte de ce diamant perdu, une rareté naturelle.
Comparison of antenatal care factors and pregnancy outcome in rural and urban context
Authors: Zile Irisa , Rezeberga Dace , Lazdane Gunta , Gavare Iveta
Published: November 2019

Antenatal care plays a basic role in the management of woman's health during pregnancy, and women who have not been registered to antenatal care are at increased risk of poor pregnancy outcome, including stillbirth. The aim of this study was to identify differences in maternal characteristics, antenatal care factors and perinatal mortality between urban and rural area in Latvia. The Medical Birth Register of Latvia (MBR) was used as a data source, all births in 2017 (n = 20,406) were included in the analysis. Mother's place of residence was categorized in 3 groups: Riga, other cities and rural area. Higher risk of smoking (OR = 1.4; p < 0.001), late first antenatal visit (after 12th gestation week) (OR = 1.2; p < 0.05) and incomplete antenatal care (including cases without care) (OR = 1.3; p < 0.05) were detected more in other regions (other cities and rural area) than in Riga. After adjustment by maternal age and education, just late first antenatal visit was significantly higher in other regions (ORadj = 1.2; p < 0.05) vs. Riga. New-born mortality in perinatal period is substantially higher in other regions vs. Riga. The results indicate health education gap and potential inequalities in receiving antenatal care and emergency obstetric care by regions.
Excellence acmeological education for the economics of the future
Authors: Efremova Nadezhda , Erkibaeva Gul’fajruz , Huseynova Anastasia
Published: November 2019

The article provides a theoretical analysis of the organisation of "excellence" education in school practice. It presents sound implementation principles of "excellence acmeological" approach to teaching in rural schools and necessary organizational and pedagogical conditions of quality education with the involvement of highly qualified teachers to ensure the educational process and increase the motivation of students to study. The paper proposes organizational and technological implementation model of "excellence acmeological" teaching in rural schools. An objective assessment of the achievement of the expected results is ensured when educational organizations turn to qualified assessment centers in order to assess the level of training among students. Much attention is given to the problems of formation and evaluation of competencies of general secondary education graduates. The excellence acmeological idea of development and self-development directs an individual to become a successful person and a highly qualified specialist.
The values of volunteering and volunteer practice among students studying in “Vocational training (by industry)”
Authors: Bazaliy Raisa
Published: November 2019

Researches of historical-pedagogical and volunteer orientation actualize. The author highlights the vivid examples of volunteer activity described in Russian history and characterizes the activity forms of charity in the difficult time of the World War I. Effective forms of disseminating the ideas and values of volunteer practice among youth are revealed; values of public service are proved, motives of dedication of a part of life of students to other people are identified. The process of formation of public opinion about volunteer activity in modern Russia is reviewed.
Individualization of the learning process consistent with the theory of multiple intelligences and learners’ cultural-cognitive profiles
Authors: Finko Margarita
Published: November 2019

The present paper considers the practices that could be applied to individualize the learning process in view of students’ intellectual and cultural-cognitive profiles. The article aims to investigate some of the theories and approaches pertaining to the realm of didactics and recognizing learners’ personal and psychophysiological needs. This line of research shall be productive in analyzing possible opportunities for differentiation and individualization of learning, which are one of the key prerequisites for the promotion of learning efficiency.
Problems of formation of civic identity of students’ personalities in modern conditions of development of Russian education and society
Authors: Bespalova Tatyana
Published: November 2019

The article presents a theoretical analysis of the problem of civic identity in the conditions of intensive development of modern social relations and the educational environment. The relevance of the study of the civic identity of a person during youth, when the formation of the self-concept is of particular importance, is described. The author’s methodology was used. The study led to the conclusion that in youth civic identity, being the central component of the “I-concept” of the individual, plays the role of a social glue that holds together the details of the social mechanism, providing a contextual structure of identity. It is shown that the majority of students are distinguished by an average level of status severity: because of personal immaturity young people do not form the semantic content of the concept of an active citizenship, that impedes the constructive overcoming of the crisis and the development of a civic identity. Correlation analysis,revealed the connection between the components of the structure of the civic identity and status, indicates the need for harmonization of the personality of young people by increasing reflection, independence, leading to the development of an internal locus of control and citizenship.
Dynamics of the EEG sensorimotor and alpha rhythm amplitude patterns in a training series of controlling the power platform with visual feedback
Authors: Makhin Sergei , Birukova Elena , Chuyan Elena , Kubryak Oleg
Published: November 2019

The study of the EEG alpha reactivity patterns in the prefrontal, central, parietal and occipital regions involved 25 healthy male subjects who participated in four training sessions of controlling the power platform with visual feedback. A significant prefrontal alpha rhythm synchronization was found which was not essentially modulated in a series of subsequent trainings. A significant desynchronization of the occipital alpha was registered for the second session which gradually increased up to the fourth session. The sensorimotor alpha rhythm didn’t show regular patterns. The use of the dominant (right) hand resulted in a significant desynchronization of the parietal alpha in the right hemisphere in the third and the fourth training sessions.
Modern Recognized Methods of Working with Non-Speaking Children of Early Age Internationally
Authors: Timofeeva Elena , Timofeeva Ksenia
Published: November 2019

This article deals with issues of organization and implementation of correctional care for young children with delayed speech development; we explore the key aspects of brain mechanisms which are fundamental to the child’s speech acquisition. Here we describe modern internationally recognized methods (Tomatis, Floortime, Theraplay) which can significantly increase the effectiveness of correctional and pedagogical work with non-speaking children. Substantial attention is paid to issues of parent-child relations.
Digital Economy and Anti-Corruption: New Digital Models
Authors: Sidorenko E.L. , Lykov A.A.
Published: November 2019

The authors of this paper consider promising areas of the corruption prevention using the latest digital technologies: Blockchain, Internet of Things, Artificial Intelligence and Big Data. The purpose of this research is the analysis of advantages of the digital economy development in terms of solving social problems and crime prevention. The authors also show functional digital models of the anti-corruption compliance are defined. In addition, the research results include the determination of some shortcomings of the proposed models associated with the imperfection of the current legislation.
Digital Platform of Industrial Cooperation – Innovative Direction of Regional Industry Development
Authors: Pudovkina O. , Sharokhina S.
Published: November 2019

The authors consider the role of the digital economy in Russia and some related processes. The aim of the study was to develop recommendations for the formation of a digital platform for the industrial cooperation. It is obvious that Russia is not a leader by the index of business digitalization (the leading countries are Finland, South Korea, and Netherlands). The authors make a conclusion about the feasibility of using a digital platform for industrial cooperation, which allows linking resources and consumers of products and services in a single information space. They also consider the creation of a regional subcontracting centre as the organizational model focused on the cooperative relations formation for production chains of large, small, and medium business, as well as on the stimulation of innovations through technology transfer, promotion opportunities for products of industrial enterprises on regional markets.
Human Capital as an Object of Accounting in the Knowledge Economy
Authors: Kogut O.
Published: November 2019

The modern economy is called the economy of effective human capital, which emphasizes its main role in the development of the economy and society as a productive factor. Human capital is becoming the most important factor in the country's economic growth, the foundation of sustainable economic development. The article considers approaches to the definition of the concept and theoretical content of the category of human capital, its importance for the development of areas of science and practice. It is revealed that human capital is a necessary independent factor determining economic growth. The necessity of reflecting human capital in the system of accounting and reporting of firms is substantiated. The main problems of recognition of this most important factor of production are revealed, the directions of their further solution are determined. The scientific and practical necessity of introducing a new object of accounting and analysis of human capital is substantiated. The article contains information and conclusions that are of practical interest to firms.
Freiheitsentziehende Maßnahmen – Hintergrund, Notwendigkeit und Alternativen
Authors: Dißmann Steffen
Published: November 2019

Festhaltemaßnahmen in der Kinder- und Jugendpsychiatrie bedeuten Stress für alle Beteiligten. Auch wenn sie die letzte Konsequenz in Ausnahmesituationen und die Hürden recht hoch sind, so kommen sie nicht selten in Form von Fixierungen und Time-out-Maßnahmen vor. Der folgende Beitrag gibt einen Überblick über die rechtlichen Rahmenbedingungen, Formen von freiheitsentziehenden Maßnahmen und die Konsequenzen für Kinder, Jugendliche, Eltern und das Personal.
Stationsäquivalente Behandlung
Authors: Holzke Martin , Heinsch Anna , Gottlob Melanie , Längle Gerhard
Published: November 2019

Ein neues Element in der psychiatrischen Versorgung ist die stationsäquivalente Behandlung – kurz StäB. Im Mittelpunkt steht der Betroffene, der in seinem familiären und sozialen Lebensumfeld aufgesucht und behandelt wird. Wir stellen die gesetzlichen Grundlagen und Rahmenbedingungen dieses individuellen, bedarfsgerechten Angebots vor und erläutern, wie es in der Praxis umgesetzt werden kann.
Morphometric Study of Distance of Axillary Nerve from Acromial Process of the Scapula in South Indian Population
Authors: B.M Lakshmi Kantha , M.J Shashanka , Mokashi Varsha
Published: November 2019

Background: The common cause of axillary nerve injury is due to lack of knowledge about the safe position of the nerve during orthopedic surgeries. Many workers have studied the safe area for axillary nerve by measuring its distance from various landmarks. The aim of the present study is to find the average distance of the location of the axillary nerve from the acromion process in the cadavers. Materials and Methods: 50 Shoulder region specimens from 25 cadavers (aged 45-55 years; both male and female sex) available in the department of Anatomy, BGS Global Institute of Medical Sciences, Bengaluru were utilized for the present study. After methodical dissection of shoulder region we measured the distance from 1) Lateral aspect of acromion processes to root of axillary nerve and 2) Posterior aspect of acromion processes to root of axillary nerve using measuring tape ( in centimeters) on both sides. The descriptive statistics including mean, standard deviation and quartile range were calculated for the measurements on both sides using SPSS software version16. Results: The mean distance of axillary nerve from the lateral edge of the acromion process was 6.39±0.8 cm on right side and 6.33±0.7cm on left side. The mean distance from posterior aspect of acromion process was 5.89±0.6 cm on right side and 5.82±0.6 cm on left side. Quartile distribution showed that, in 75% individuals the distance between lateral aspect of acromion process and axillary nerve was 7cm on both sides. The distance between posterior aspect of acromion process and axillary nerve was 6.4 cm on right side and 6.5 cm on left side. Conclusion: Knowledge of morphometric distance of axillary nerve from the acromion process is important in deltoid split surgeries and while giving intramuscular injection to deltoid region.
A Study of Variations in the Origin of Obturator Artery in the Human Cadavers and its Clinical Significance
Authors: Kumar Sanjeev , Minz Smita
Published: November 2019

Background and aims: Study of origin of obturator artery, its variable origin and course is significant as knowledge attained by such studies help surgeons to avoid injuries, hemorrhage during operative procedures. Present study is aimed at finding out the variable origin of obturator artery, clinical significance and to correlate its embryological basis. Materials and Methods: Present study was conducted on 60 formalin fixed hemi section of cadaveric pelvis, which were allotted to the under graduate students of Mandya Institute of Medical Sciences, Mandya. Observations obtained were compared with the studies of previous workers. Results: Normal pattern of origin, from the anterior division of internal iliac artery was seen in 40% (24 cadavers). In 60% of the cadavers variations were observed. The most common variant mode of origin was from inferior epigastric artery (18.3%). Next common was origin from superior gluteal artery and least common variant of origin was from inferior vesical artery. Conclusion: Variations observed in present study were at par with the variations observed by previous studies. Although anomalous origins of the obturator artery rarely produces clinical symptoms, their knowledge is necessary for operating surgeons to avoid injuries and is of academic interest.
Effectiveness of Flipped Classroom for Teaching Anatomy and Students’ Perceptions
Authors: Viveka S , Sagar T Vijay , Sudha M J
Published: November 2019

Background and objectives: A flipped classroom concept involves inverting the classroom teaching activities. Here, the learner learns the ‘core’ concepts before the class, usually at home, reading and watching an online video, at his will. The aim of current study was to evaluate the effectiveness of flipped classroom for teaching concepts in anatomy. The subject chosen was cranial nerves. Methodology: Ninety-two students participated in this study. Four topics from cranial nerves were selected for the project. Regular lecture classes were taken for first two topics. Flipped classroom was used for the next two. Videos intended for flipped classroom were made available to all students through WhatsApp platform and blog post 48 hours prior to class. Assessment was by MCQs – 25 from topics covered by conventional method and 25 from flipped classroom topics. Score of 50% was considered as pass. Number of students in pass and fail category were compared through chi- square test. Results:Mean scores after regular and flipped classes were 12.92 (SD ± 3.13) and 13.41 (SD ± 3.38) respectively. Fifty eight students passed after flipped classroom teaching and 47 students passed after regular class. The number of students passing after flipped class as compared to regular class is statistically significant. Perceptive rating of flipped classroom concept was 4.15 out of 5 in comparison to traditional methods. Conclusion: Flipped classroom is effective in learning anatomy. Studies pursued for longer duration with broader subject coverage are suggested.
Clinical Variability of Pallister–Killian Syndrome in Two Egyptian Patients
Authors: Eid Maha M. , Eid Ola M. , Abdel-Hadi Sawsan , Hassib Nehal , Madian Abdelrahman , Afifi Hanan H. , Abdel-Salam Ghada M. H.
Published: November 2019

Pallister–Killian syndrome (PKS) is a rare sporadic genetic disorder caused by a mosaic tetrasomy of chromosome 12p, which mainly manifests with craniofacial dysmorphism, intellectual disability (ID), auditory disturbance, epilepsy, and a variety of congenital malformations. The diagnosis of PKS can be complicated due to the phenotypic variation, and an overlap with other syndromes makes the molecular cytogenetic test necessary for a correct diagnosis. We identified two unrelated patients with typical facial features of PKS, including bitemporal alopecia, hypertelorism, and abnormal ears. Furthermore, the two patients had pigmentary skin anomalies, broad and short hands and fingers, and hypotonia. However, they differed in the degree of ID and ophthalmological findings. Patient 1 showed profound ID and poor macular function, whereas patient 2 had moderate ID and normal fundus. Mosaic tetrasomy of chromosome 12p was found in 40 and 25% of the cells of patients 1 and 2, respectively, by fluorescent in situ hybridization of cultured skin fibroblasts. The higher percentage of mosaic cells with tetrasomy 12p found in patient 1 may explain the severe phenotype. This report expands the clinical manifestations of PKS and highlights the variable expressivity of clinical features in relation to the cytogenetics findings.
In situ XRD measurements to explore phase formation in the near surface region
Authors: Manova Darina , Mändl Stephan
Published: November 2019

Though X-ray diffraction (XRD) is a well-established technique—yet still continuously evolving—for characterization of thin films and diffusion layers, there are two inherent limitations due to the underlying physical principles leading to the diffraction: (i) all data are a weighted integral across the information depth and (ii) X-ray amorphous or nanocrystalline phases are very difficult to be detected. The purpose of this Perspective is to show how a straightforward combination of in situ XRD with depth profiling using a laboratory experiment in combination with a low-energy broad-beam ion source may allow us to overcome these limitations for functional surfaces. Whereas time-resolved investigations of diffusion and phase formation during ion implantation using reactive species are well established, using ion beam sputtering with nonreactive species for depth profiling of the phase composition during the measurements is a rather recent development. While employing analysis of differential spectra leads to a depth resolution below the information depth, ongoing in situ sputtering will lead to information obtained from layers deeper than the information depth. Keeping track of the total diffraction intensity permits the identification of phases without reflections in the XRD measurements, i.e., they appear to be amorphous, and their depth distribution. Selected examples drawn mainly from investigations of the nitriding kinetics of austenitic stainless steel will be used to demonstrate the potential and possible limitations of this method.
Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models
Authors: Bargiela Ariadna , Sabater-Arcis Maria , Espinosa-Espinosa Jorge , Zulaica Miren , Lopez de Munain Adolfo , Artero Ruben
Published: November 2019

Myotonic dystrophy type 1 (DM1) is a life-threatening and chronically debilitating neuromuscular disease caused by the expansion of a CTG trinucleotide repeat in the 3′ UTR of the
DMPK
gene. The mutant RNA forms insoluble structures capable of sequestering RNA binding proteins of the Muscleblind-like (MBNL) family, which ultimately leads to phenotypes. In this work, we demonstrate that treatment with the antiautophagic drug chloroquine was sufficient to up-regulate MBNL1 and 2 proteins in
Drosophila
and mouse (HSA
LR
) models and patient-derived myoblasts. Extra Muscleblind was functional at the molecular level and improved splicing events regulated by MBNLs in all disease models. In vivo, chloroquine restored locomotion, rescued average cross-sectional muscle area, and extended median survival in DM1 flies. In HSA
LR
mice, the drug restored muscular strength and histopathology signs and reduced the grade of myotonia. Taken together, these results offer a means to replenish critically low MBNL levels in DM1.
Evidentiality in adverbs of manner of perceivability
Authors: Carretero Marta
Published: November 2019

This paper presents an analysis of the expression of evidentiality by the English adverbsmanifestly, noticeably, patentlyandvisibly(MNP&V). I propose that the adverbs have a meaning of manner and an evidential meaning, and that both meanings often coexist, in which case evidentiality is shown to be a pragmatic implication of the meaning of manner. An account is provided of the factors of the linguistic context that trigger MNP&V’s evidential meaning, as a single meaning or as an implication: propositional scope, realis assertion, no premodification by degree adverbs mapping on to a construal of totality and no coordination with adverbs of manner. Position is also shown to strengthen or weaken the evidential implication when MNP&V have syntactic clausal scope. The evidentiality expressed by MNP&V is also characterised according to mode of access, domain, subjectivity and reliability. The adverbs have been submitted to a quantitative analysis of all their occurrences in the British National Corpus; the results show that MNP&V are evidential by implication in most cases, and also uncover individual differences in features such as position and domain of evidence and in the extent to which each adverb can be considered as an evidential expression.
The influence of the temporal shape of a fiber laser radiation pulses in the process of destruction the shell explosive objects
Authors: Shepelev A E , Solokhin S A , Ershkov M N , Antipov A A , Putilov A G , Arakelyan S M
Published: November 2019

This article is devoted to the process of remote exposure to the radiation of fiber laser on metal shell explosive objects. The advantages of fiber lasers that allow their use in demining complexes are described. The paper presents an experimental study of the effect of fiber laser radiation profiled and non-profiled pulses on metal simulators of explosive objects. It is established that the effect of profiled pulses compared to the non-profiled allows to significantly reduce the melting time of the sheath and to decrease the required laser energy.
The concept and design of navigation systems based on solid-state and semiconductor lasers
Authors: Fedin A.V. , Fedina M.A.
Published: November 2019

The concept and design of the navigation system based on solid-state and semiconductor lasers is presented. The possibility of using a laser with a self-reversal of a radiation wavefront with a beam quality parameter M2 ⩽ 1.2 and a single-frequency pulse power of more than 20 MW for constructing a master oscillator of a solid-state laser emitter is considered. The possibility of using a 100 W multi-cell continuous semiconductor laser for constructing a master oscillator of a semiconductor laser emitter with a fiber output is demonstrated.
Formation of optical antennas interfaces by laser processing of thin metal coatings
Authors: Chkalov R V , Khorkov K S , Kochuev D A , Vasilchenkova D G , Prokoshev V G
Published: November 2019

The work is devoted to the problem of creating interfaces of metallic nanoantennas for optoplasmonics. The technology of micro- and nanoscale elements topology formation by the method of selective laser ablation of thin-film coatings is described. The possibility of using the femtosecond laser complex for rapid prototyping of various geometric configurations of optical antennas interfaces is shown.
Mapping of graphene layers by program identification based on Raman spectroscopy data
Authors: Ilyin V A , Khorkov K S , Chkalov R V , Kochuev D A , Prokoshev V G
Published: November 2019

This article discusses the basic methods of carbon structures research. Software has been proposed for determining the number of graphene layers based on the processing of spectral data obtained using Raman spectroscopy. The results of the analysis are presented in the form of micro-Raman maps of the distribution of the number of graphene layers.
The plasmonic nanoparticles with controlled optical properties
Authors: Eliseev N N , Kuz’mina A S , Putilov A G , Shepelev A E , Arakelian S M , Lotin A A
Published: November 2019

The gold and silver plasmon nanoparticles have been synthesized on the c-sapphire and p-silica substrates by the pulsed laser deposition method. It has been demonstrated that the variation of the thickness of as-grown gold and silver films permits producing the plasmon nanoparticles with different size and density. It provides the retuning of the frequency of surface plasmon resonance in wide spectral region.
New controllable electrophysics and optics of granulated thin films: the 4D laser-induced topological nanoclusters
Authors: Arakelian S M , Osipov A.V. , Bukharov D V , Istratov A V , Khudaiberganov T A
Published: November 2019

The modeling of functional characteristics (electrophysics + optics) of topologically different nanocluster system deposited on solid surface is consid9erated. Both energetic electronic levels and mobility of electrons are strongly depended on the cluster shape, their spatial distribution, and can be modified in a necessary way for possible applications in the photonics thin film elements.
Measurement of electronic temperature of laser-induced plasma channels at various pressures in argon by relative intensities of spectral lines
Authors: Tarasova M A , Kochuev D A , Galkin A F , Vasilchenkova D G , Chernikov A S , Khorkov K S , Prokoshev V G
Published: November 2019

In this paper, we study the properties of laser-induced plasma channels formed by femtosecond laser radiation in argon. The electron temperature of the plasma channels is calculated by the method of relative intensities of spectral lines.
Tribological properties of nanostructured coatings for roller screw mechanisms
Authors: Morozov V. , Kochetov D. , Dovbysh N. , Zhdanov A.
Published: November 2019

In this paper, a comparative analysis of two nanostructured PVD-coatings based on chromium is carried out. Tribological and physical-mechanical characteristics of these coatings for friction RSM rollers are determined. Kinematic characteristics of roller screw mechanism with these types of coatings are obtained, ranges of kinematic transfer functions of friction roller screw mechanism with nanostructured PVD-coatings based on chromium are determined.
Acoustic waves in polariton wires
Authors: Kozin V. K. , Yulin A. V. , Nalitov A. V. , Iorsh I. V. , Shelykh I. A.
Published: November 2019

The interaction of exciton-polariton condensates with acoustic phonons in a polariton wire is analyzed. For the case of a coherently pumped condensate we demonstrate that above a certain threshold the parametric instability in the system develops and leads to the generation of an acoustic wave and polariton harmonics with a lower frequency.
Conditions for Bose–Einstein condensation in periodic background
Authors: Bordag M
Published: November 2019

We investigate Bose–Einstein condensation of a noninteracting gas of Bose particles moving in the background of a periodic lattice of delta functions. In the one-dimensional case, where one has no condensation in the free case, this property persists also in the presence of the lattice for all examples which are considered in the present paper and we could only formulate some conditions which are necessary for condensation. We also considered the three-dimensional case and showed that the lattice does not destroy condensation. We calculated, for small coupling, the change in the critical temperature, which is lowered by the lattice. Finally, we took another, more general view on the problem using heat kernel expansion, and discuss BEC for Casimir effect related configurations.
Rubberized concrete filled steel tube
Authors: Abuzaid O. , Nabilah A.B. , Safiee N.A. , Noor Azline M.N.
Published: November 2019

One of the solution to reduce tire waste is by incorporating rubber as fine aggregate replacement, producing a rubberized concrete. This type of concrete generally has lower compressive strength, however, could potentially be used as structural application due to its inherent ductility. This study explored the application of rubberized concrete filled steel tube (RCFST) as structural member. A review of available literature has indicated the lack of experimental data for RCFST. Hence, an experimental study was conducted for circular composite columns with different thicknesses, 2.75mm, 4mm and 5mm, where each were filled with (a) normal concrete and (b) rubberized concrete with 10% fine aggregate replacement. The behaviour of RCFST was studied in terms of strength and ductility under axial compression load. From material testing, it was found that the compressive strength of rubberized concrete was approximately 30% less than that of the normal concrete. However, the axial load capacity of RCFST was only 1.4% to 6.6% less than the control samples (CFST). It was also found that the RCFST possesses some ductility and could be used for structures undergoing vibrations and seismic loads. As the overall behaviour of RCFST is comparable with the control CFST, rubberized concrete has the potential to be used as a filler material in steel tube to form composite column.
The impact of BIM application on construction delays and cost overrun in developing countries
Authors: Tahir Muhammad Muhammad , Azam Haron Nuzul , Hizami Aidi , Alias  , Taha Al-Jumaa Azher , Bala Muhammad Isa
Published: November 2019

Delays and cost overruns are generally acknowledged in the construction industry as serious issues that require the use of advanced technologies. However, the adoption of new technologies has not kept pace with the growth of the industry. This is due to low studies on the impact of these technologies in the industry. Building Information Modelling (BIM) as an alternative technology for management of construction is still in its early stage of adoption in many countries. This research tends to determine the relationship between the use of BIM and the causes of delay and cost overrun in construction industry. Data were obtained through admininstered questionnaires to Contractors, which was analysed using Pearson’s product-moment correlation to determine their relationships at 0.05 level of significance. The results from the analysis of the causes of delay and the causes of cost overrun shows that there is a positive correlation between the two (r=0.737, n = 69, p = 0.000). More also, the result of the analysis shows that there is a significant negative relationship between the application of BIM and the causes of delay and cost overrun (r = -0.246, n = 69, p = 0.041) and (r = -0.313, n = 69, p = 0.009). The result of this research shows that an increase in the use of BIM in the management of construction projects reduces the occurrence of delay and cost overrun.
Post Occupancy Evaluation Measures of Green Interiors Tools Energy Efficiency (EE) Core Criteria
Authors: Yaman R , Abdullah J , Adnan H , Ismail F Z , Ahmad N
Published: November 2019

Interior spaces sustainable rating system in Malaysian is rather new. Even though Green Building Index Interior Tools (GBI-IT) has been developed and implemented but there is lack of post-occupancy evaluation being conducted in assessing the sustainability level of the certified project, particularly on the Space Energy Intensity (SEI). Thus, embarking on the research problem whether the certified interior space sustainable level is according to the pre-occupancy scoring benchmark as vision by the designers upon occupancy, particularly on Energy Efficiency (EE). The research objective is to examine the SEI, to identify similarities and discrepancies of SEI upon pre-occupancy evaluation and post occupancy evaluation and to assess the key EE sub-criteria that affect Space Energy Intensity (SEI) and to improve continuing sustainable EE upon post occupancy. The Space Energy Intensity equation approach and implementation method is used in this research in order to measure total space energy consumption per year/interior space area. The research design will be formulated into three key stages, which are; 1. Content analysis of GBI Interior Tools EE core criteria; 2. Comparative data analysis between pre-occupancy and post-occupancy EE sub-criteria scoring and; 3. Assessment of key EE sub-criteria that affect Space Energy Intensity (SEI) and to improve continuing sustainable EE upon post occupancy. The findings for research problem based on Space Energy Intensity (SEI) on-site measure from case study will improve sustainability practice and continuing sustainable agenda particularly on EE. The study outcome will facilitate and enhance the current and future sustainable approach in interior SEI.
Spatial and Statistics for Profiling Risk Factors of Diseases: A Case Study of Tuberculosis in Malaysia
Authors: Abdul Rasam A R , Mohd Shariff N , Dony J F , Othman F
Published: November 2019

Understanding concepts of a proper disease transmission risk is not a straightforward process. In the context of tuberculosis (TB) dynamics, the concepts require the exploration of two meticulous criteria to produce an accurate epidemic modelling of the risk areas of the disease. The criteria include interpreting the biological transmission of the disease and applying multidisciplinary approaches. Spatial statistics were used to evaluate the preferences of risk factors in Shah Alam, Malaysia. GIS-multicriteria decision making (MCDM) method and logistic regression method were specifically integrated to select the local risk factors and seven influential factors were ranked accordingly i.e. human mobility, high risk group, socio-economic status (SES), population, type of house, distance of factory and urbanisation. Each has relative risk rate that affects the cases and the combination of them will even impact more on the overall risk concentration of TB. Human–based factors are identified as dominant effects to the risk than biophysical factors, for example, a location of TB risk will be increased by four times if individuals are living together with people who have TB disease for a particular time period. This geospatial method is expected to predict a better factor prediction in identifying hotspot areas of the disease.
Survey Based Sustainable Socio-Cultural Guidelines for Neighbourhood Design in Jeddah
Authors: Fatani Khadijah A. , Mohamed Mady , Al-Khateeb Samah
Published: November 2019

Today, many neighbourhoods around the world are suffering from several problems. These problems affected the culture, social interaction, economic aspects as well as environmental impacts. Accordingly, urban development should address social and cultural aspects of each particular community within the environmental and economical context. The current research aims at developing a set of design guidelines that promotes the concept of socially sustainable neighbourhoods in Saudi Arabia. Several rating systems and urban design codes around the world set guidelines for urban design development and particularly in neighbourhood design. LEED (Leadership of Environment and Energy design) for neighbourhood design, and QSAS (Qatar Sustainability Assessment System); are examples of these rating system. Nonetheless, these rating systems are not applicable in the context of Saudi Arabia without considering its local social and cultural aspects. Therefore, this research resulted as a reaction to the abbreviation of socio-cultural aspects in neighbourhood design approaches. This research depends on an analytical review of different neighbourhood design approaches and case studies. In addition, subjective data is collected from experts and professionals about their points of view and their recommendations regarding neighbourhood design for Jeddah city. The result of the research is a set of design guidelines that consists of design principles adjusted to fit the context of Saudi Arabia (Jeddah City). The formulated guidelines are adapted and tested in an evaluation application of two residential neighbourhoods in Jeddah city. This application validated the proposed design guidelines. Considering the proposed design guidelines; in the design process of Jeddah’s neighbourhoods, this will promote a leading approach to the concept of socially sustainable neighbourhoods in the kingdom.