bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct oral anticoagulants and travel-related venous thromboembolism
Authors: Chamnanchanunt Supat , Rojnuckarin Ponlapat
Published: November 2018

Travel- related thromboembolism reflects the relationship between venous thromboembolism (VTE) and long-haul flights. Although this condition is rare, it may cause significant morbidity and mortality. Therefore, travelers should be evaluated for the risks for thrombosis. Travel physicians should employ a clinical risk score and select in vestigations, prophylaxis, and treatment that are appropriate for each individual. This review summarizes current VTE clinical risk scores and patient management from various reliable guidelines. We summarized 16 reliable publications for reviewing data. Direct oral anticoagulants (DOACs) are currently the standard treatment for VTE and a prophylactic measure for VTE in orthopedic surgery. Compared with a vitamin K antagonist (VKA), DOACs show better safety and similar efficacy without the need for monitoring, and have fewer food/drug interactions. Inferred from the data on general VTE, DOACs may be used to treat travel-related VTE. Although the data are lacking, DOACs may be used off-label as VTE prophylax is. Before using DOACs, physicians must know the pharmacology of the drugs well and should realize that the availability of antidotes for bleeding complications is limited.
“Nonetheless They Will Have Need of Wood”: Aesthetic and Utilitarian Approaches to Trees inThe SilmarillionandUnfinished Tales
Authors: Simonson Martin
Published: November 2018

A common assumption about J.R.R. Tolkien’s works is that they are escapist, only dealing obliquely with issues related to the real world. This has been addressed in the field of literary studies by linking Tolkien’s literary output with twentieth-century concerns such as modernist practices and, in recent times, by reading his tales against the backdrop of ecocriticism. However, scholars in the latter field, such as Dickerson, Evans, and Campbell, frequently over-emphasize wonder and the spiritual connection with the natural world as the intended response of readers, which undermines the potential implications and relevance of Tolkien’s works for the real world. In this article I wish to show that Tolkien’s cosmological vision is not only premised on the idea of appreciating the wonder-inciting qualities of the world but that it also entails a certain amount of utilitarianism, and the need to combine both is related to the ethical theory of ideal utilitarianism as outlined by G.E. Moore. Moreover, in several early episodes ofThe Silmarillion, the combined approach to the natural world is represented by trees, setting a mythical precedent for later works. Of the latter, I will be looking mainly at “Aldarion and Erendis” inUnfinished Talesand “The Downfall of Númenor” inThe Silmarillion.
Architectural Remnants and Mythical Traces of the Haitian Revolution:
Authors: Minosh Peter
Published: November 2018

In Architectural Remnants and Mythical Traces of the Haitian Revolution: Henri Christophe's Citadelle Laferrière and Sans-Souci Palace, Peter Minosh examines two works of architecture related to the Haitian Revolution: the Citadelle Laferrière and Sans-Souci Palace, built under Henri Christophe, who reigned as the first king of Haiti from 1811 until his death in 1820. No archival records exist regarding the construction of these neoclassical edifices, and even their architects are unknown; all that remain are literary productions and mythical traces. Yet these traces point, productively, to a mythos behind this architecture—that of the enslaved who formulated a political space outside the terms of the colonial project, as well as that of the colonizer for whom the very suggestion of a slave insurrection would undermine France's colonial mercantile economy. Minosh takes the Citadelle Laferrière and Sans-Souci Palace to be architectural instantiations of these mythic configurations and shows that these artifacts of the world's first independent black nation attempt to solidify in architecture the ephemeral condition of insurgency.
Pola Asuh dan Peer Group terhadap Konsep Diri Remaja tentang Perilaku Seksual
Authors: Najib Najib
Published: November 2018

Abstrak

Masa remaja merupakan masa dimana seorang individu mengalami peralihan yang penuh dengan permasalahan. Salah satu permasalahan pada remaja yang berisiko adalah masalah perilaku seksual remaja. Faktor yang memengaruhi perilaku reproduksi remaja diantaranya adalah faktor keluarga dan pergaulan remaja. Penelitian ini bertujuan untuk mengetahui pengaruh pola asuh orangtua dan peer group terhadap konsep diri remaja tentang perilaku seksual pada siswa SMK. Jenis penelitian ini survei analitik dengan desain penelitian cross sectional. Responden penelitian ini adalah siswa/siswi dan orangtua SMK Negeri di Kota Semarang sebanyak 387 orang dan diambil dengan purposive sampling. Analisis bivariat menggunakan uji Chi Square. Hasil menunjukkan Peer group Buruk (73,8), Pola Asuh orangtua Otoriter (57,9%), dan Konsep Diri Baik (68,3). Uji statistik menunjukkan adanya hubungan Peer group dengan konsep diri remaja tentang perilaku seksual di SMK Negeri di Kota Semarang (P= 0,009;C=0,134), 35,5% konsep diri Buruk dengan peer group yang buruk. Ada hubungan Pola Asuh Orang Tua dengan konsep diri remaja tentang perilaku seksual di SMK Negeri di Kota Semarang (P=0,003;C=0,153), 37,9% pola asuh otoriter mengakibatkan konsep diri yang buruk. Penelitian ini menyimpulkan bahwa pola asuh orang tua dan peer group berhubungan dengan konsep diri remaja terkait perilaku seksual.

 

Abstract

The period for the future of individual transition is full of problems. One of the problems in adolescents who are at issue is the problem of adolescent governance. Factors that influence adolescents are family factors and teenage relationships. This study aimed to determine the effect of parenting and peer grouping on adolescent self-concept about sexual behavior in vocational students. This type of research was analytic survey with cross sectional research design. Respondents of this study were 387 public vocational high school students in Semarang City and taken by purposive sampling. Bivariate analysis used Chi Square test. The results showed the Poor Group (73.8), the Authoritarian Asuhahulu Pattern (57.9%), and the Good Self Concept (68.3). Statistical test shows that there is a relationship between Peer group and adolescent self-concept in Semarang City State Vocational High School (P = 0.009; C = 0.134), 35.5% Bad self concept with poor peer group. There is a relationship between parenting and self-concept in state vocational schools in the city of Semarang (P = 0.003; C = 0.153), 37.9% authoritarian parenting that is bad. This study concluded that parenting and peer group were related to sexual concepts.
EGE DENİZİ’NDEKİ KARASULARI SORUNUNUN TÜRK VE ULUSLARARASI DENİZ TİCARETİ’NE ETKİLERİ
Authors: CEYHUN Gökçe Çiçek
Published: November 2018

Günümüz dünyasında devletlerin en temel stratejilerinden biri, enerji hatlarını ve enerji kaynaklarını kontrol altına alarak rekabet güçlerini geliştirmektir. Türkiye, coğrafi konumunun verdiği üstünlükten kaynaklanan nedenlerle özellikle deniz alanları açısından rekabet gücü yüksek ülkeler arasında yer almaktadır. Bu nedenle Türkiye, yük taşımacılığından aldığı yüksek pay ve deniz ticareti açısından bölgede oynadığı kilit rol ile denizlere ilişkin uyguladığı politikalar açısından dikkat çekici bir konumdadır. Deniz ticareti açısından durum incelendiğinde, denizin statüsüne göre her ne kadar transit geçiş ve zararsız geçiş gibi rejimler öngörülse de, denizlerdeki aidiyet tartışmasının, bu geçişlerde kullanılan ticari rotaları da etkileyeceği düşünülmektedir. Özellikle bazı deniz alanlarında ticari gemilerin izleyeceği rotaların, geçiş rejimine bağlı olması, bu alanlardaki özgürlüğü etkileyeceğinden, sınırlandırma konusundaki kararların uluslararası ticarete etkide bulunması olasıdır. Tüm bu nedenlerden dolayı, bu çalışmada Ege Denizi’ndeki karasuları sınırlandırmalarına ilişkin gelişmelerin ülkemiz deniz ticareti ve uluslararası deniz ticaretine olası etkileri değerlendirilmiştir. Araştırma kapsamında derinlemesine literatür taraması yapılmış, deniz ticaret rotalarına ilişkin haritalar aracılığıyla mevcut durum incelenmiş ve olası senaryolar tartışılarak, geleceğe yönelik tedbir ve öngörüler sunularak çalışma sonlandırılmıştır. Anahtar Kelimeler: Ege Denizi, karasuları, deniz ticareti
EFFICIENCY OF PHARMACEUTICAL CONSUMPTION IN TURKEY: BENCHMARKING WITH OECD BY DEA
Authors: BOZOKLU Çağla Pınar , KESKİN BENLİ Yasemin
Published: November 2018

After 1980s, consumers begin to focus more health-conscious behaviours and attitudes including the concept of consuming pharmaceutical products. Pharmaceutical consumption attitude is a natural outcome of this trend. In this research, it is aimed to analyze Turkey’s benchmarking position among OECD countries in terms of pharmaceutical consumption efficiency. 15 OECD countries’ 5 years (2008-2012) analyzed by DEA-Malmquist TFP with the output-oriented and variable returns to scale methods. TC index shows that Turkey had created more pharmaceutical consumption and longer life expectancy by using same amount of number of physicians, number of pharmacists, total public and private health insurance expenditures and number of doctor consultations. By the way, Turkey had embraced efficiency growth with the rate of 0.4 percent. However, total efficiency level of Turkey got damaged by reason of its administrative limitations.
BİST’DE İŞLEM GÖREN KÂĞIT VE KÂĞIT ÜRÜNLERİ BASIM VE YAYIN İŞLETMELERİNİN TOPSİS, PROMETHEE VE COPRAS YÖNTEMLERİYLE FİNANSAL PERFORMANSLARININ BELİRLENMESİ
Authors: AKYÜZ Fatma , YEŞİL Tolga , KARA İsmail , ERSOY Gürsel
Published: November 2018

Kağıt ve Kağıt Ürünleri Basım ve Yayın sektöründe de son zamanlarda ithalata bağımlı olunmasından dolayı üretim maliyetleri yükselmiştir. Bu noktada çalışmada Kağıt ve Kağıt Ürünleri Basım ve Yayın sektörün tercih edilmiş olup, sektörde lider durumda olan işletmeler çok kriterli karar verme yöntemleri ile belirlenmeye çalışılmıştır. Bu çalışmada, Borsa İstanbul’da işlem gören Kâğıt ve Kâğıt Ürünleri Basım ve Yayın sektöründeki işletmelerin 2012-2017 yılları arasındaki finansal performansları, çok kriterli karar verme yöntemlerinden olan TOPSİS (Technique for Order Preference by Similarity to Ideal Solution), PROMETHEE (Preference Ranking Organization Method for Enrichment  Evaluation) ve COPRAS (Complex Proportional Assessment) yöntemleriyle ölçülmeye çalışılmıştır. Araştırma örneklemini BİST’de işlem gören 14 işletme oluşturmaktadır. Çalışmada ilk olarak çok kriterli karar verme yöntemlerinde kullanılan finansal oranlar açıklanmış ve daha sonra TOPSİS, PROMETHEE ve COPRAS yöntemlerinin uygulama basamaklarına yer verilmiştir. Finansal oranların hesaplanması aşamasında, ilgili işletmelerin 2012-2017 yılları arasındaki finansal tabloları Kamuyu Aydınlatma Platformundan alınan veriler ışığında kullanılmıştır. Araştırma sonucunda, her bir yöntem için söz konusu işletmelerin 2012-2017 yılları arasındaki 6 dönemlik performanslarının 10 finansal oranla değerlendirilmesi yapılarak, elde edilen sonuçlar arasında karşılaştırma yapılmıştır.
DOES EMPLOYER BRANDING AFFECT JOB EMBEDDEDNESS? THE MEDIATING ROLE OF DEDICATION AND PERCEIVED ORGANIZATIONAL SUPPORT
Authors: TATAR Berivan , MÜCELDİLİ Büşra , ERDİL Oya
Published: November 2018

Along with emerging the war for talent, scholars have given ample attention to employer branding concept referring the a whole of values and benefits that organizations provide for both attracting and retaining the best possible talent. In this context, the purpose of this study is to investigate the effect of employer branding on the favorable employee behavior as job embeddedness via the mediating role of the dedication and perceived organizational support.  Data collected from 200 respondents have been analyzed through Structural Equation Modeling. As a result of analyses, the hypothesized model was supported. Findings of the study revealed that employer branding has effect the dedication, job embeddedness and organizational support perception of employees. Additionally, dedication and perceived organizational support partially mediate the relationship between employer branding and job embeddedness. Finally, the theoretical and practical implication, limitations of the study and suggestions for future research are discussed.
THE MODERATING ROLE OF MODERN TRAINING AND DEVELOPMENT METHODS IN PRIVATE BANKS AND WORK PERFORMANCE: EVIDENCE FROM CONTRACTUAL EMPLOYEES WORKING IN PAKISTAN BANKING SECTOR
Authors: FARIDI Adnan , BALOCH Akhtar
Published: November 2018

The article attempts to investigate the moderating role and effect of the modern methods of training and development programs in private banks on the individual work performances of the employees. Through area cluster sampling technique survey questionnaire, the data was gathered from 280 employees working at the operational level in 8 major cities of Pakistan. The results confirmed that the private banks have significant contribution in improving the overall performances of the banking sector whereas modern methods of training and development has statistically significant effect on enhancing the working performance of contractual employees. The frequently evident practices; professionalism and employee engagement developed through training are considered and both have significant relationship with the enhanced work performance of employees. Hence, modern training and development methods are pivotal moderator in improving the working efficiency of the private banks and enhancing the knowledge, skills and abilities of the contractual workforce.
It takes two (centrioles) to tango
Authors: Avidor-Reiss Tomer , Fishman Emily L
Published: November 2018

Cells that divide during embryo development require precisely two centrioles during interphase and four centrioles during mitosis. This precise number is maintained by allowing each centriole to nucleate only one centriole per cell cycle (i.e. centriole duplication). Yet, how the first cell of the embryo, the zygote, obtains two centrioles has remained a mystery in most mammals and insects. The mystery arose because the female gamete (oocyte) is thought to have no functional centrioles and the male gamete (spermatozoon) is thought to have only one functional centriole, resulting in a zygote with a single centriole. However, recent studies in fruit flies, beetles and mammals, including humans, suggest an alternative explanation: spermatozoa have a typical centriole and an atypical centriole. The sperm typical centriole has a normal structure but distinct protein composition, whereas the sperm atypical centriole is distinct in both. During fertilization, the atypical centriole is released into the zygote, nucleates a new centriole and participates in spindle pole formation. Thus, the spermatozoa’s atypical centriole acts as a second centriole in the zygote. Here, we review centriole biology in general and especially in reproduction, we describe the discovery of the spermatozoon atypical centriole, and we provide an updated model for centriole inherence during sexual reproduction. While we focus on humans and other non-rodent mammals, we also provide a broader evolutionary perspective.
Incidencia del tipo de alimento sobre la sobrevivencia y ecdisis en Callinectes bocourti en cultivo para la obtención de jaiba blanda en el caribe colombiano
Authors: Lozano-Beltrán Germán , Orozco-Acosta Erick , Rodríguez-Díaz Klaus , Muñoz-Salas Karen
Published: November 2018

La investigación tuvo como propósito determinar la incidencia del tipo de dieta sobre la sobrevivencia y la ecdisis en la jaiba roja (Callinectes bocourti) en cultivo, para obtener jaiba suave como alternativa de producción pesquera en el Caribe colombiano. Se realizaron 2 experimentos: 1. pescado fresco / pescado fresco + Ca+ y 2. pescado fresco / alimento concentrado para camarón (34% proteína). En 4 módulos de recirculación independiente, de 4 acuarios cada uno articulados a filtros biológicos, se sembró un ejemplar/acuario (64 jaibas por ensayo) y se realizaron 3 series de 45 días cada uno. En el experimento 1, sobrevivieron 378 ejemplares, 203 (53.7%) correspondieron a la dieta de pescado fresco y 175 (46.3%) al grupo alimentado con pescado fresco + Ca+. En el experimento 2, sobrevivieron 293 ejemplares (21.8%), 180 (61.4%) consumieron pescado fresco y 113 (38.6%) alimento para camarón. En el experimento 1, no se encuentra relación entre la dieta y la ecdisis. En el experimento 2, se encuentra relación entre el sexo (hembra) y la ecdisis. Se concluye que C. bocourti es una especie con dificultades para manejo en cultivo y la sobrevivencia no depende de la dieta. El sexo (hembra) es una variable por considerar en la ecdisis de C. Bocourti, dado que las hembras requieren mayor energía para el proceso de maduración. La adición de Ca+ al alimento natural no tiene mayor implicación en la ecdisis; puede haber mayor relación con variables ambientales y procesos hormonales que con la ingesta de Ca+.
Caracterización de los ecosistemas costeros al norte del Área Protegida de Recursos Manejados Península de Guanahacabibes, Cuba
Authors: Cobián Dorka , Perera Susana , Pérez Alina , Aguilar Susana , Álvarez Anmaris , Hernández Zaimiuris , Espinosa Leonardo , Salvat Héctor , Alcalá Alain , Ezquivel Macario , Hernández Leslie
Published: November 2018

LaPenínsula de Guanahacabibes fue propuesta como Área Protegida de Recursos Manejados (APRM) en el Sistema Nacional de Áreas Protegidas de Cuba. Para validar esta propuesta se realizó un estudio de caracterización al área, en el marco del proyecto “Aplicación de un enfoque regional al manejo de las áreas protegidas marinas y costeras en los archipiélagos del sur de Cuba”, con el objetivo de caracterizar los ecosistemas costeros y reafirmar que la ubicación y extensión diseñada del APRM responden a la protección de los principales valores naturales. Se evaluaron los manglares, las lagunas costeras y los pastos marinos, así como los sitios más importantes para las comunidades de aves marinas y acuáticas y las poblaciones de manatíes. Los muestreos se realizaron con metodologías validadas en el marco del proyecto. Se presentan los resultados que constituyen la línea base del área, identificándose 149 especies de algas, 4 especies de fanerógamas marinas, 53 especies de peces del manglar y 39 especies de aves marinas y acuáticas. Los sitios seleccionados como prioridades de conservación y manejo de hábitats y especies incluyen los sitios de alimentación y nidificación de las aves marinas y acuáticas y la ubicación de dos zonas importantes para el monitoreo del manatí. Se identificaron las principales problemáticas del área, con el objetivo de realizar futuras acciones de conservación y manejo de los recursos naturales.AbstractThe Guanahacabibes Peninsula was proposed as a Managed Resource Protected Area (APRM) in the CubanNational System of Protected Areas. In order to validate this proposal a study was conducted as part of the project“Implementation of a Regional Approach to the Management of Marine and Coastal Protected Areas inSouthern Cuban Archipelagos”, with the purpose of characterizing coastal ecosystems and reassuring that theAPRM designed location and extension correspond to the protection of the main natural resources of the region.Mangroves, coastal lagoons and seagrass were assessed as well as important sites for seabird and waterfowlcommunities and manatee populations. Sampling was conducted with methods validated in the project.Results included the baseline of the area and identified 149 algae species, 4 seagrass species, 53 mangrove fishspecies, and 39 seabird and waterfowl species. The sites selected as priority for habitat and species conservationand management include feeding and nesting sites for seabirds and waterfowl and two important sites forthe manatee. The main problems for the area were identified for future conservation and management actions.
Temporal variation, growth and natural mortality of two species of mojarras (Perciformes: Gerreidae) from a tropical coastal lagoon: La Carbonera, Yucatan, Mexico
Authors: Bonilla-Gómez José Luis , Badillo-Alemán Maribel , Gallardo-Torres Alfredo , Chiappa-Carrara Xavier
Published: November 2018

This study reports seasonal variation, growth parameters and natural mortality for Eucinostomus gula and Eucinostomus argenteus inhabiting La Carbonera, a tropical coastal lagoon on the northwestern coast of theYucatan Peninsula, Mexico. Specimens were collected between April 2009 and March 2010. A total of 2700organisms of E. gula (> 80% in rainy season ) and 1577 organisms of E. argenteus (>50% in dry season)were collected during the study period. Length-weight relationship (LWR) obtained was W = 8.323E-03Lt2.92 in E. argenteus and W = 7.314E-03 Lt2.92 in E. gula. Growth parameters of von Bertalanffy growthfunction (VBGF) by length frequency analysis were in E. argenteus: L∞ = 13.65 cm, k = 0.54 year-1 and t0= - 0.37 years; and in E. gula: L∞ = 12.60 cm, k = 0.68 year-1 and t0 = - 0.28 years. Additionally, estimatednatural mortality in E. gula was 1.50 year-1 and in E. argenteus was 1.9 year-1. This study presents the firstestimation for both species of model parameters, growth performance index and mortality for the Yucatan Peninsula, which is relevant for the proper implementation of conservation measures for E. gula and E. argenteus in an important coastal zone of the Yucatan Peninsula.Se reportan la variación temporal, los parámetros de crecimiento y la mortalidad natural para Eucinostomus gula y Eucinostomus argenteus que habitan en la laguna costera tropical La Carbonera, al noroeste de la península de Yucatán, México. Los especímenes fueron recolectados entre abril de 2009 a marzo de 2010. Un total de 2 700 organismos de E. gula (> 80% en la estación lluviosa) y 1 577 organismos de E. argenteus (> 50% en la estación seca) fueron recolectados durante el período de estudio. Se determinó la relación peso-longitud (RPL) como: P = 8.323E-03 Lt 2.92 en E. argenteus y P = 7.314E-03  Lt2.92 en E. gula.  Para E. argenteus, los parámetros de crecimiento de la ecuación de crecimiento de von Bertalanffy (ECVB) fueron: L∞ = 13.65 cm,  k = 0.54 año-1 y t0 = - 0.37 años; mientras que para E. gula fueron: L∞ = 12.60 cm, k = 0.68 año-1 y t0 = - 0.28 años. La mortalidad natural en E. gula fue 1.50 año-1 y en E. argenteus fue 1.9 año-1. Este estudio presenta la primera estimación para ambas especies de los modelos de crecimiento, el índice del desempeño de crecimiento y la mortalidad natural para la península de Yucatán, lo que es relevante para la adecuada implementación de medidas de conservación de E. gula y E. argenteus en una valiosa zona costera de la península de Yucatán.
Disrespecting people with working conditions in South Africa
Authors: Emuze Fidelis , Mollo Lesiba
Published: November 2018

The working conditions of people mostly play second fiddle to productivity and profitability in construction. Anecdotal and empirical construction reports, mostly in developing countries such as South Africa, suggest inappropriate social interactions on project sites. The awkward social interactions manifest through lack of respect for workers, who are regarded as people with limited rational abilities. Using three case studies from South Africa as an illustration for the discourse, this paper argues that on-site working conditions are critical to the well-being of people at the front line of construction work. For example, poor working conditions are indicative of a disrespectful attitude towards the people on a site. Further, both poor working conditions and lack of respect for people (RFP) constitute a significantly negative influence on the general well-being of workers and their managers. This paper thus argues that it is time to translate the notion of RFP into actual practice in the interest of employees and employers in the industry.
microC: A 3D virtual microenvironment for perturbation biology v1
Authors: Voukantsis Dimitrios , Kahn Kenneth , Hadley Martin , Wilson Rowan , M Buffa Francesca
Published: November 2018

microC is a multiscale virtual microenvironment for perturbation biology. It enables experiments that link genotype to phenotype taking into account the surrounding microenvironment. microC has a modular architecture that enables a wide variety of experiment. Furthermore, it offers easy access to advanced computational modelling and supercomputing resources to the wider scientific community. microC combines agent-based and gene network modelling and uses partial differential equations to simulate interactions among cells. The tool itself does not require any installation on the user’s machine, as it can be accessed using a web browser. Experimental results and data are also available via a web interface. This protocol describes the process of preparing and submiting an experiment with microC, and interpreting the simulation results
Analysis of bixin contents in Bixa orellana seeds v1
Authors: Carballo-Uicab Victor , Cárdenas-Conejo Yair , Vallejo-Cardona Alba , Aguilar-Espinosa Margarita , Rodríguez-Campos Jacobo , Serrano Posada Hugo , Alberto Narváez Zapata José , Renata Rivera-Madrid not provided
Published: November 2018

Analysis and comparison of immature seeds in this study were particularly important since bixin accumulation is higher in immature than in mature seeds
bright field standard swarming imaging v1
Authors: Ding Serena
Published: November 2018

For imaging swarming behaviour of 40 young adult C. elegans on agar using the Phoenix multi-worm tracker system. Worms are synchronised by bleaching and refeeding for 72 hours, and then 40 young adult hermaphrodites are transferred by glass pipette onto a 35 mm regular NGM plate for imaging for 7 hours at 25 fps.
bright field pheromone imaging v1
Authors: Ding Serena
Published: November 2018

For imaging aggregation behaviour of 40 young adult C. elegans on agar using the Phoenix multi-worm tracker system. Worms are synchronised by bleaching and refeeding for 72 hours, and then 40 young adult hermaphrodites are transferred by glass pipette onto a 35 mm regular NGM plate for imaging for 1 hour at 25 fps.
cDNA synthesis of Bixa orellana v1
Authors: Carballo-Uicab Victor , Cárdenas-Conejo Yair , Vallejo-Cardona Alba , Aguilar-Espinosa Margarita , Rodríguez-Campos Jacobo , Serrano Posada Hugo , Alberto Narváez Zapata José , Rivera-Madrid Renata
Published: November 2018

The SuperScript™ III First-Strand Synthesis System for RT-PCR is optimized to synthesize first-strand cDNA from purified poly(A)+ or total RNA.
Computational Steps for Analyzing Deep Single Molecule Sequencing Reads of Simple Sequence Repeats - Control SSRs v2
Authors: P Harhay Gregory
Published: November 2018

Simple sequence repeats (SSR) are segments of genome sequence made up of multiple copies of a short sequence (from one to several nucleotides), repeated in series. SSRs are present in prokaryotes(Moxon 2006)and eukaryotes(Toth 2000) however, their biological roles are not fully understood. In some bacterial genomes, SSR length variation has been shown to affect phenotype(van der Woude 2004). SSR length variation occurs through slip-stranded mispairing (SSM) of DNA at a rate of up to a million-fold greater than the average bacterial mutation rate and is therefore termed hypermutable(Moxon 2006). This mode of mutation has been observed in both gram-positive(Danne 2014)and gram-negative bacteria(Inzana 2013)and shown to affect host adaptation, virulence, and pathogenicity. Here we use single-molecule real-time sequencing and a dedicated data processing pipeline to demonstrate that a laboratory culture ofHistophilussomni, prepared from a single, presumably clonal colony, consists of a population ofdistinctsequence phase and read length variant profiles at individual SSR loci. To discriminate between sequencing artifact and biological signal, we employed chemically synthesized control duplexes that we sequenced to create a dataset to tune our computational approach to account for artifacts.Using these control duplexes, we observed low levels of SSM for thePacBio polymerase used in SMRT sequencing.To the best of our knowledge, we present the first protocol for the observation of SSR length variabilityat the single DNA molecule level that accounts for sequencer SSM artifact. Our results demonstrate a method to detect and quantify SSR length heterogeneity in a mixed population of DNA molecules and show that specific SSR regions inHistophilus somniare not static structures well-represented by a single consensus sequence, but rather dynamic structures with length variation differences in multiples of complete repeat unit with characteristic SSM profiles and sequence phase. Immediate applications of this method include direct monitoring of SSR-mediated phase variable gene switching and the development of genome assemblies and annotation that more accurately reflect the sequence diversity of extant genomes. This method may be more broadly applied to study the potentially species-specific interactions of DNA and RNA polymerases and regulatory biomolecules on the one hand, with variations in SSR repeat unit sequence, repeat unit sequence phase, repeat unit length, and hypermutable total length on the other. In this protocol we validate the computaitonal approaches presented here by sequenciing chemically synthesized oligos and annealed to a form duplexes. These oligos are slightly shorter version of the AAGC SSR found in CP018802.1.
ATIVIDADES ANÍMICAS, SUSTENTABILIDADE E CULTURA DE PAZ: O CASO DA FORMAÇÃO “NAVEGANDO”
Authors: Ribeiro Ivana Campos , Sorrentino Marcos , Rodrigues Carolina Souza , Silva David Ramos , Schwartz Gisele Maria
Published: November 2018

A insustentabilidade na forma do viver humano faz repensar o papel da educação no sentido da construção de valores para sociedades sustentáveis, não apenas para o desenvolvimento de estudantes, mas dos próprios educadores. A presente proposta de formação objetiva a avaliação da metodologia “Navegando”, baseada em experiências lúdicas e anímicas, as quais estimulam os educadores participantes a refletirem sobre seus valores e atitudes, no sentido da correção de rotas que conduzem à sustentabilidade, a partir da efetivação dos conceitos de paz interior, paz social e planetária. A metodologia propunha vivências com as atividades lúdicas e anímicas com educadores como estratégia para o fomento da conduta sustentável do educador, exemplo a ser percebido pelos estudantes. Os resultados indicaram a ampliação do conceito de sustentabilidade, incorporando a dimensão biopsíquica, favorecendo a identificação de fatores internos causadores de desequilíbrio e a possibilidade da revisão de valores e condutas.
La jerarquía militar. Conceptos y terminología
Authors: Álvarez Díaz Juan José
Published: November 2018

Desde los inicios de su deambular terrestre, los seres humanos conformaron grupos jerarquizados que les permitían realizar con eficacia aquellas tareas que eran imprescindibles para su supervivencia, como la caza, la guerra y, posteriormente, las labores agrícolas y otras muchas.Las estructuras jerárquicas fueron haciéndose cada vez más complejas, a medida que la sociedad humana se desarrollaba, y, en la misma medida, lo hizo el lenguaje, incorporando palabras y expresiones que facilitaban la comunicación y servían mejor al ejercicio de cada una de estas tareas. Y, de todas ellas, la guerra, por su transcendencia e importancia, es la que ha requerido constituir, para su eficaz desempeño, una organización compleja, fuertemente jerarquizada y dotada permanentemente de recursos e individuos, a la que denominamos ejército.El lenguaje militar, o lenguaje que se utiliza en el ejército tiene características propias que contribuyen a la eficacia, siendo una de las más importantes la precisión lingüística. Para lograrlo, los militares disponen de un léxico que es específico, abundante y preciso y, en la comunicación, procuran utilizar un estilo claro, conciso y concreto.El propósito de este trabajo es mostrar el léxico español relacionado con la jerarquía militar, explicando el significado de cada palabra y subrayando, cuando procede, las diferencias entre algunas de ellas que pertenecen a un mismo campo semántico, con objeto de que se pueda apreciar la complejidad y la diversidad de conceptos que utiliza el lenguaje militar en este ámbito.
Capuano, Thomas M. comp. (2017): Diccionario herbario de textos antiguos y premodernos, New York, Hispanic Seminary of Medieval Studies, 2017, xxxii + 495 pp.
Authors: Jiménez Ríos Enrique
Published: November 2018

Reseña de Capuano, Thomas M. comp. (2017): Diccionario herbario de textos antiguos y premodernos, New York, Hispanic Seminary of Medieval Studies, 2017, xxxii + 495 pp.
Los principios procesales del trabajo:
Authors: Goyes Moreno Isabel , Hidalgo Oviedo Mónica
Published: November 2018

El proceso del trabajo suele asociarse con determinadas y excluyentes jurisdicciones. El servicio público, el juicio disciplinario y el trabajo particular tienen procedimientos específicos que deben incluirse en un concepto amplio del manejo del conflicto en materia laboral. La tesis del presente texto es articular dichos estancos en torno a principios que los  rijan indistintamente, pues a pesar de las tensiones entre precedentes de una y otra Corte, el trabajo independiente o subordinado, público o privado, requiere soluciones uniformes, que recurran a desarrollos jurisprudenciales de obligatoria observancia por mandato constitucional y legal. Dada su importancia procesal,  se explora el principio de buena fe, donde resultan evidentes la armonía y desarmonías entre Corte Constitucional, Consejo de Estado y Corte Suprema de Justicia.
Kızartma Prosesinin Atık Bitkisel Yağlardan Elde Edilen Biyodizel YAME Ürünü Üzerine Etkilerinin Araştırılması
Authors: Doğan Tuba Hatice
Published: November 2018

Biyodizel genellikle
yüksek saflıkta yağlar kullanılarak, alkali katalizörlü transesterifikasyon
reaksiyonu ile üretilir. Ancak hammadde olarak yemeklik bitkisel yağların
kullanımı, biyodizelin en önemli dezavantajlarından biri olan maliyetini
arttırır. Her yıl tüm dünyada çok miktarda atık kızartma yağı oluşmaktadır. Bu
yağlardan biyodizel üretilmesiyle, hem yakıt maliyetinin düşürülmesine yardımcı
olunacak hem de çevreye ve ekonomiye önemli katkılar sağlanmış olunacaktır.
Bitkisel yağların kızartma prosesi sırasında maruz kaldıkları pişirme şartları,
yağda bir takım değişikliklere sebep olmaktadır. Yağdaki değişiklikler
bunlardan üretilen biyodizelin de bazı özelliklerini etkilemektedir. Bu
çalışmada, tuz oranı, su oranı, kızartma sıcaklığı ve kızartma süresi gibi
farklı kızartma şartlarına maruz bırakılan ve atık hale getirilen üç farklı
bitkisel yağdan biyodizel üretilmiştir. Bitkisel yağların kızartma şartlarının
üretilen biyodizelin yağ asiti metil ester (YAME) ürününü nasıl etkilediği
incelenmiştir. Biyodizel örneklerinin yağ asiti metil ester içerikleri gaz
kromatografisi ile ölçülmüştür.  Sonuç
olarak, tüm bitkisel yağların tuz oranı, su oranı, kızartma sıcaklığı ve
kızartma süresi arttıkça üretilen biyodizel örneklerinin ürün miktarının
azaldığı tespit edilmiştir. Ayrıca, kızartma prosesinin en fazla mısırözü
yağını ve buna bağlı olarak mısırözü biyodizelini olumsuz yönde etkilediği de
görülmüştür.
Expressing the randomity of events – An analysis of random number generation with given distributions
Authors: Zhou Carl
Published: November 2018

In cases where it is necessary to generate random numbers that obey specific distributions, some of those distributions can be expressed as mathematical functions while others cannot. This is especially the case for epidemiological, medical, and pharmaceutical investigations, where more accurate methods, utilising actual distribution (from survey and experimental data) to generate random numbers may be required. In this study, three methods are analyzed to demonstrate simple computation examples. These methods include: inverse transform,acceptance-rejection, and Monte-Carlo simulations. Their applications are explored from a data analysis point of view. Additionally, this article discusses a flexible and practical approach of statistical measures optimization, which approximates the solution by fitting the statistical measures.
Investigating graphene oxide permeable reactive barriers for filtering groundwater contaminated from hydraulic fracturing
Authors: An Zifeng , Grala Konrad , Panchal Aakanx , Trivedi Kunjan
Published: November 2018

Hydraulic fracturing, or fracking, is a method of natural gas extraction which involves pumping a brine solution into the ground to create a fracture that will allow natural gas to rise. One of the major concerns surrounding this method of natural gas extraction is that wastewater enters the groundwater supply, thereby contaminating it. This wastewater contains toxic materials such as heavy metal ions, radionuclides and other salts and organic compounds in high concentrations. Some of these materials are carcinogenic and thus a concern to human life and the environment. The current solution involves the use of a zerovalent iron (ZVI) permeable reactive barrier (PRB) to filter out these toxic substances. However, it causes more fouling due to the accumulation of mineral precipitates and therefore is not very effective. A recent development in nanotechnology may allow us to develop a superior water filter to prevent groundwater contamination. Therefore, a novel PRB is suggested: featuring the use of solid graphene oxide (GO), a nanomaterial with a superior sorption ability is proposed as a replacement for the system. The proposed experiment will test the filtration capability of the GO-PRB as compared to the traditional ZVI-PRB. By emulating the process of groundwater contamination and flow using common materials found in fracking wastewater, we can determine how much more effective the GO-PRB is than the ZVIPRB.
The effects of radium-226 in cattle and predicted impacts of cancer
Authors: Eijaz Nayha , Gnanamanogaran Bhairavei , Kapoor Paras , Naraentheraraja Saranya
Published: November 2018

Hydraulic fracturing is a controversial method of natural gas extraction that has gained its fair share of critics. Although research has been conducted on the environmentalimpact of fracking, research concerning naturally occurring radioactive materials (NORM) has been scarce. Radionuclides are known to bioaccumulate in the environment and can have toxic effects on humans. This study aims to examine the extent of biomagnification of radium-226 in soil, crops and animals. Fluid samples from areas near fracking sites will be compared with samples from non-fracking sites via gamma spectroscopy. Homogenized samples of soil and crops will be analyzed by gamma spectroscopy while milk and cattle meat samples will undergo alpha spectroscopy. This will provide a clear image of the process of bioaccumulation and magnification of radionuclides in the environment as a byproduct of fracking.
Toxoplasmosis congénita en el valle de México. Resultados de una serie de casos
Authors: Gómez Toscano Valeria , Linares López Karen Alejandra , Arce Estrada Gabriel Emmanuel , Figueroa Damián Ricardo , Barrios Bautista Diana Miriam , Hernández Luengas Liliana , Bonilla Ríos Christian Alejandro , Tecuátl Herrada Blanca Luz , Luna Pastén Héctor , Macías Parra Mercedes , Cañedo Solares Irma , Saltigeral Simente Patricia , Ortiz Alegría Luz Belinda , Bosch Canto Vanesa , Rico Torres Claudia Patricia , Ordaz Favila Juan Carlos , Vargas Villavicencio José Antonio , López Candiani Carlos , Xicoténcatl García Lizbeth , Hernández Antúnez Blanca Gloria , Ruiz García Matilde , Escobedo Torres Mónica Patricia , Rivera González Iván Rolando , González González Luis Oscar , Mora González Juan Carlos , Paredes-Alonzo Iris Evelin , Flores Lechuga Ana María , Hernández Delgado Lorena , Correa Dolores
Published: November 2018

ANTECEDENTES: En México prevalecen cepas “virulentas” de Toxoplasma gondii, por lo que el cuadro clínico puede ser diferente a los reportados para regiones donde circulan cepas no virulentas, como Europa, Estados Unidos y Canadá.MÉTODOS: Se reporta una serie de casos con toxoplasmosis congénita reclutados a partir de 2005 por tamiz prenatal o postnatal, o porque llegaron como casos clínicos al INP, y que conforman parte de una serie de casos.RESULTADOS: Todos los pacientes presentaron manifestaciones clínicas, pero el  grupo de tamiz prenatal presentó una infección más localizada y menos grave, principalmente con espasticidad y retraso psicomotor leve. El grupo de tamiz postnatal presentó características clínicas intermedias, con retraso psicomotor leve, moderado o grave, bajo peso al nacimiento, micro o hidrocefalia, ictericia, hepatomegalia, esplenomegalia, calcificaciones intracraneales y espasticidad. Los pacientes más afectados fueron aquellos que se presentaron como casos clínicos, con una amplia variedad de manifestaciones clínicas y el peor pronóstico, incluida la muerte. Seis pacientes presentaron comorbilidades. Veinte casos fueron positivos para dos o más pruebas de laboratorio; el resto sólo para una.CONCLUSIONES. Nuestros resultados apoyan que la toxoplasmosis congénita en México es más grave que en otros países, y que urge implementar tamiz prenatal efectivo, para prevención y profilaxis.PALABRAS CLAVE: complejidad diagnóstica; evaluación prenatal; heterogeneidad clínica; tamiz postnatal; tamiz prenatal; toxoplasmosis congénita; Toxoplasma gondii
Uso de antipiréticos en Pediatría
Authors: Gómez Toscano Valeria
Published: November 2018

La fiebre es un signo que se manifiesta junto con múltiples enfermedades infantiles; por tanto, es motivo frecuente de consulta al pediatra o médico general. Acompaña lo mismo a enfermedades triviales y de alivio espontáneoque a las graves que ponen en peligro la vida. La causa no necesariamente es infecciosa, puede tener un fondo inmunológico o neoplásico, pero su presencia indica actividad inflamatoria.
Оценка перспектив взаимодействия регионального бизнеса в АПК Енисейской Сибири
Authors: Васильева Зоя Андреевна , Лихачева Татьяна Петровна , Руйга Ирина Рудольфовна , Филимоненко Ирина Владимировна
Published: November 2018

В статье рассмотрена возможность взаимодействия регионов Енисейской Сибири с целью покрытия потребности населения в продуктах питания и, как следствие, обеспечения их продовольственной безопасности. Выделены следующие целевые характеристики экономического фактора, влияющего на продовольственную безопасность: объем производства продовольствия, цена продуктов питания, экономическая и физическая доступность, состояние аграрного производства, уровень продовольственного обеспечения.
Была произведена характеристика составляющих экономического фактора по каждому региону Енисейской Сибири и определена тенденция их влияния на совокупную продовольственную безопасность.
Reframing the global poverty and inequality narrative in development education through the lens of intersectionality
Authors: Gyoh Son
Published: November 2018

The effort to promote interdisciplinary research in development and global education risks the erosion of its core values by more theoretically established fields of development. This becomes urgent when little research attention is given to strengthening the theoretical foundation
of core concepts and themes, such as global poverty and inequality, that are grounded in knowledge from field experience. This article responds to the influence of neoclassical literature about poverty and spatial inequality that propagates a discourse shift from poor countries to poor people.
Intersectionality is explored as a paradigm that can reconcile this new thinking with the social justice pedagogy of development education and that enables an understanding of the asymmetries in current patterns of poverty and spatial inequality.
Short-term results after minimally invasive and open liver resection for liver metastases of colorectal cancer: a single center experience
Authors: Efanov M. G. , Alikhanov R. B. , Tsvirkun V. V. , Kazakov I. V. , Kim P. P. , Vankovich А. N. , Grendal K. D. , Zamanov Е. N.
Published: November 2018

Rationale: Until now, safety of minimally invasive liver resection (MILR) has not been studied sufficiently.

Aim: To assess immediate results of MILR and open type resections in patients with colorectal metastases, performed in the Russian center of surgical hepatology specialized at implementation of minimally invasive techniques.

Materials and мethods: This was a retrospective observational case-control study. Patients who underwent surgery for isolated liver metastases of colorectal cancer in a  single center from October 2013 to February 2018 were included into the study.

Results: As per December 2017, over 500 resections have been performed in the study center, including 226 MILR. One hundred two patients underwent open resection and MILR for colorectal metastases. From 83 patients enrolled into the study, 51 (61%) had MILR, including 7 robotic MILR. The open resection and MILR groups did not differ in terms of gender, age, ASA score, primary tumors location and stage by the time of primary intervention. There were no between-group differences for factors that determine the tumor spread and influence the resection problems, i.e. the difficulty index of MILR, rate of anatomic resection, resection of complex segments, vascular involvement, size and number of metastases, multiple liver lesions and bilobar metastases. No difference was found for immediate outcomes in terms of frequency of the free surgical margin > 2 mm, rate of the Pringle maneuver implementation, duration of the procedure, blood components transfusion, severe complications (Clavien-Dindo Grade > II), and time in intensive care unit. Compared to open procedures, MILR were associated with significantly less blood loss: 583 (50–3000) mL vs. 308 (0–3300) mL (p = 0.012), respectively, and shorter duration of hospital stay: 10 (4–29) days vs. 9 (4–29) days (р < 0.001), respectively.

Conclusion: In a specialized surgical hepatology center, MILR can be performed equally to complex open procedures without changes in the rates and types of complications, but with an improvement of immediate outcomes.
Psychometric Properties of the Extended Nursing Stress Scale: Measuring Stress in Workplace
Authors: Alkrisat Muder , Alatrash Manal
Published: November 2018

Background: Despite its popularity, the psychometric properties of the Extended Nursing Stress Scale (ENSS) in working adults are yet to be evaluated in different settings. Methods: This study examined the ENSS in acute care settings among licensed nurses through a questionnaire survey. The sample responses were examined using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Results: A response rate of 37% was achieved; 199 licensed nurses completed the questionnaire. Workplace stress was found to have factorial structures similar to those in the previous studies that had different samples. In this sample, all subfactors had satisfactory coefficients ranged between .58 and .89. The goodness of fit indices met the usual criteria. The reliability ranged between .64 and .95. Conclusions: The ENSS showed a stable structure with reasonable internal consistency and construct validity.