bluuebunny/crossref_metadata_2025 huggingface dataset:
Tannic Acid and Ethyl Gallate Potentialize Paclitaxel Effect on Microtubule Dynamics in Hep3B Cells
Authors: Sánchez-Carranza Jessica Nayelli , Redondo-Horcajo Mariano , Barasoain Isabel , Escobar-Aguilar Ever Angel , Millán-Pacheco César , Alvarez Laura , Salas Vidal Enrique , Diaz J. Fernando , Gonzalez-Maya Leticia
Published: November 2023

Among broad-spectrum anticancer agents, paclitaxel (PTX) has proven to be one of the most effective against solid tumors for which more specific treatments are lacking. However, drawbacks such as neurotoxicity and the development of resistance reduce its therapeutic efficacy. Therefore, there is a need for compounds able to improve its activity by synergizing with it or potentiating its effect, thus reducing the doses required. We investigated the interaction between PTX and tannins, other compounds with anticancer activity known to act as repressors of several proteins involved in oncological pathways. We found that both tannic acid (TA) and ethyl gallate (EG) strongly potentiate the toxicity of PTX in Hep3B cells, suggesting their utility in combination therapy. We also found that AT and EG promote tubulin polymerization and enhance the effect of PTX on tubulin, suggesting a direct interaction with tubulin. Biochemical experiments confirmed that TA, but not EG, binds tubulin and potentiates the apparent binding affinity of PTX for the tubulin binding site. Furthermore, the molecular docking of TA to tubulin suggests that TA can bind to two different sites on tubulin, one at the PTX site and the second at the interface of α and β-tubulin (cluster 2). The binding of TA to cluster 2 could explain the overstabilization in the tubulin + PTX combinatorial assay. Finally, we found that EG can inhibit PTX-induced expression of pAkt and pERK defensive protein kinases, which are involved in resistance to PXT, by limiting cell death (apoptosis) and favoring cell proliferation and cell cycle progression. Our results support that tannic acid and ethyl gallate are potential chemotherapeutic agents due to their potentiating effect on paclitaxel.
Therapeutic Activity of a Topical Formulation Containing 8-Hydroxyquinoline for Cutaneous Leishmaniasis
Authors: de Lima Sarah Kymberly Santos , Cavallone Ítalo Novaes , Serrano Dolores Remedios , Anaya Brayan J. , Lalatsa Aikaterini , Laurenti Márcia Dalastra , Lago João Henrique Ghilardi , da Silva Souza Dalete Christine , Marinsek Gabriela Pustiglione , Lopes Beatriz Soares , de Britto Mari Renata , Passero Luiz Felipe Domingues
Published: November 2023

Cutaneous leishmaniasis exhibits a wide spectrum of clinical manifestations; however, only a limited number of drugs are available and include Glucantime® and amphotericin B, which induce unacceptable side effects in patients, limiting their use. Thus, there is an urgent demand to develop a treatment for leishmaniasis. Recently, it was demonstrated that 8-hydroxyquinoline (8-HQ) showed significant leishmanicidal effects in vitro and in vivo. Based on that, this work aimed to develop a topical formulation containing 8-HQ and assess its activity in experimental cutaneous leishmaniasis. 8-HQ was formulated using a Beeler base at 1 and 2% and showed an emulsion size with a D50 of 25 and 51.3 µm, respectively, with a shear-thinning rheological behaviour. The creams were able to permeate artificial Strat-M membranes and excised porcine skin without causing any morphological changes in the porcine skin or murine skin tested. In BALB/c mice infected with L. (L.) amazonensis, topical treatment with creams containing 1 or 2% of 8-HQ was found to reduce the parasite burden and lesion size compared to infected controls with comparable efficacy to Glucantime® (50 mg/kg) administered at the site of the cutaneous lesion. In the histological section of the skin from infected controls, a diffuse inflammatory infiltrate with many heavily infected macrophages that were associated with areas of necrosis was observed. On the other hand, animals treated with both creams showed only moderate inflammatory infiltrate, characterised by few infected macrophages, while tissue necrosis was not observed. These histological characteristics in topically treated animals were associated with an increase in the amount of IFN-γ and a reduction in IL-4 levels. The topical use of 8-HQ was active in decreasing tissue parasitism and should therefore be considered an interesting alternative directed to the treatment of leishmaniasis, considering that this type of treatment is non-invasive, painless, and, importantly, does not require hospitalisation, improving patient compliance by allowing the treatment to be conducted.
Mitigating Environmental Effects in Halide Perovskites through Hybrid Perovskite-Polymer Nanocomposites: A Short Review
Authors: Mavuso Mlungisi Arnold , Msimanga Mandla
Published: November 2023

Metal halide perovskites are currently making notable strides in the development of next-generation optoelectronic and photovoltaic devices. Prototype lab-based devices have exhibited high efficiencies for photovoltaic applications. However, the high performance cannot be maintained for practically useful lengths of time due to degradation of the perovskite layer on exposure to environmental factors such as moisture, oxygen, and heat. This limits the widespread use of these materials in commercial devices. This review of hybrid perovskite-polymer nanocomposites begins by highlighting the significant structural and optoelectrical properties of metal halide perovskites. The discourse moves on to the elucidation of the deleterious effects of environmental stressors on the movement of charge carriers in photovoltaic devices based on these materials. Various mitigatory measures are then considered, with the narrative eventually narrowing down to perovskite-polymer nanocomposites, where the synergistic combination of the two materials is critically analyzed. The conclusion looks at the challenges and opportunities presented by polymer-metal halide perovskite nanocomposites and the potential role they may play in the development of low-cost photovoltaic and optoelectronic devices.
Single-Spin Asymmetry of Neutrons in Polarized pA Collisions
Authors: Kopeliovich Boris Z. , Potashnikova Irina K. , Schmidt Iván
Published: November 2023

Absorptive corrections, which are known to suppress proton-neutron transitions with a large fractional momentum z→1 in pp collisions, become dramatically strong on a nuclear target, and they push the partial cross sections of leading neutron production to the very periphery of the nucleus. The mechanism of the pion π and axial vector meson a1 interference, which successfully explains the observed single-spin asymmetry in a polarized pp→nX, is extended to the collisions of polarized protons with nuclei. When corrected for nuclear effects, it explains the observed single-spin azimuthal asymmetry of neutrons that is produced in inelastic events, which is where the nucleus violently breaks up. This single-spin asymmetry is found to be negative and nearly atomic mass number A-independent.
Antagonistic Activity of Streptomyces alfalfae 11F against Fusarium Wilt of Watermelon and Transcriptome Analysis Provides Insights into the Synthesis of Phenazine-1-Carboxamide
Authors: Dong Dan , Li Maoying , Zhang Taotao , Niu Zhenfeng , Xue Guoping , Bai Hongmei , Zhao Wenyu , Yu Jiajia , Jiang Wei , Wu Huiling
Published: November 2023

Streptomyces alfalfa strain 11F has inhibitory effects on many phytopathogenic fungi and improves the establishment and biomass yield of switchgrass. However, the antagonistic effects of strain 11F on Fusarium wilt of watermelon and its secondary metabolites that contribute to its biocontrol activity are poorly understood. We evaluated the antagonistic and growth-promoting effects of strain 11F and conducted a transcriptome analysis to identify the metabolites contributing to antifungal activity. Strain 11F had marked inhibitory effects on six fungal pathogens. The incidence of Fusarium wilt of watermelon seedlings was decreased by 46.02%, while watermelon seedling growth was promoted, as indicated by plant height (8.7%), fresh weight (23.1%), and dry weight (60.0%). Clean RNA-sequencing data were annotated with 7553 functional genes. The 2582 differentially expressed genes (DEGs) detected in the Control vs. Case 2 comparison were divided into 42 subcategories of the biological process, cellular component, and molecular function Gene Ontology categories. Seven hundred and forty functional genes (55.47% of the DEGs) were assigned to Kyoto Encyclopedia of Genes and Genomes metabolic pathways, reflecting the complexity of the strain 11F metabolic regulatory system. The expression level of the gene phzF, which encodes an enzyme essential for phenazine-1-carboxylic acid (PCA) synthesis, was downregulated 3.7-fold between the 24 h and 48 h fermentation time points, suggesting that strain 11F can produce phenazine compounds. A phenazine compound from 11F was isolated and identified as phenazine-1-carboxamide (PCN), which contributed to the antagonistic activity against Fusarium oxysporum f. sp. niveum. PCA was speculated to be the synthetic precursor of PCN. The downregulation in phzF expression might be associated with the decrease in PCA accumulation and the increase in PCN synthesis in strain 11F from 24 to 48 h. Streptomyces alfalfae 11F protects watermelon seedlings from Fusarium wilt of watermelon and promotes seedling growth. The transcriptome analysis of strain 11F provides insights into the synthesis of PCN, which has antifungal activity against F. oxysporum f. sp. niveum of watermelon.
Genetic Diversity of Barley Accessions from East Asia for Greenbug Resistance
Authors: Radchenko Evgeny E. , Abdullaev Renat A. , Akimova Daria E. , Anisimova Irina N.
Published: November 2023

The greenbug, Schizaphis graminum, is a dangerous pest of barley and other grain crops in the south of Russia. An effective and environmentally friendly way to control this insect is to cultivate resistant varieties. The differential interaction between the phytophage and host plants necessitates the search for new donors of resistance. Seven hundred and seventy-eight accessions of barley from East Asian countries (313 from China, 450 from Japan, and 15 from Nepal) were evaluated for greenbug resistance. The Krasnodar population of the insect and clones isolated from it were used in the experiments. Forty heterogeneous accessions were identified, in which plants with a high level of resistance to the aphid were found. As a result of damage assessment by the 108 S. graminum clones of 11 lines selected from heterogeneous accessions, 52 insect virulence phenotypes were identified. Experiments with aphid test clones showed that all 11 lines possess diverse greenbug resistance alleles, which differ from the previously identified Rsg1, but their efficiency is low. The frequency of clones virulent to ten lines and the cultivar Post (a carrier of the Rsg1 gene) varies from 60.4% to 98.0%. The exception is line 15903, which is resistant to the aphid population and protected by one dominant gene. The high resistance of other lines against a part of the natural population of S. graminum is also under oligogenic control. Lines 15600 and 16190 each have one dominant resistance gene, and line 28129 is protected by two genes, the dominant and recessive ones. A recessive resistance gene is presumably present in line 15600. Lines 16237/1 and 16237/2, isolated from the same collection accession, each have one dominant gene effective against individual aphid clones. The loss of effectiveness of distinctly manifested resistance genes causes the expression of previously masked genes with a weak phenotypic manifestation, which differentially interact with insect genotypes.
Eucalyptus camaldulensis Dehnh Leaf Essential Oil from Palestine Exhibits Antimicrobial and Antioxidant Activity but No Effect on Porcine Pancreatic Lipase and α-Amylase
Authors: Jaradat Nidal , Al-Maharik Nawaf , Hawash Mohammed , Qadi Mohammad , Issa Linda , Anaya Rashad , Daraghmeh Ayham , Hijleh Lobna , Daraghmeh Tasneem , Alyat Amal , Aboturabi Ro’a
Published: November 2023

Eucalyptus camaldulensis Dehnh is a tree species that is commonly used for various purposes, including forestry, agroforestry, and conservation. The present investigation was designed to determine the composition of E. camaldulensis leaves essential oil and estimate its free radicals, porcine pancreatic lipase, α-amylase inhibitory, and antimicrobial properties in vitro. The chemical constituents were analyzed using the gas chromatography-mass spectrometry (GC-MS) technique. DPPH (2,2-diphenyl-1-picrylhydrazyl), p-nitrophenyl butyrate, and 3,5-dinitro salicylic acid (DNSA) methods were employed to estimate the antioxidant, antiobesity, and antidiabetic effects of the essential oil. The microdilution assay was employed to assess the antimicrobial efficacy of the substance against a total of seven distinct microbial species. The GC-MS results revealed that E. camaldulensis essential oil contains 52 components that makeup 100% of the entire oil. The main chemical constituents in E. camaldulensis essential oil are p-cymene (38.64%), followed by aromadendrene (29.65%), and 1,8-cineol (6.45%), with monocyclic monoterpene being the most abundant phytochemical group, followed by the sesquiterpene hydrocarbon group, representing 44.27 and 31.46%, respectively. The essential oil showed a weak antioxidant effect and had no antilipase or antiamylase effects. At the same time, the oil showed a strong antimicrobial effect against methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, and Proteus vulgaris, which was even more potent than the positive controls, ciprofloxacin and ampicillin, which had MIC doses of 0.2 ± 0.01, 0.2 ± 0.01, and 6.25 ± 0.1 µg/mL, respectively. It also has a strong anti-Candida albicans effect with a MIC of 0.2 ± 0.01 µg/mL. In light of these findings, in vivo studies should be conducted to determine the efficiency of the E. camaldulensis essential oil in treating microbial infections.
Development of Highly Hygienic Textile by Coating with Encapsulated Ginseng Oil
Authors: Ryu Sujin , Shim Jaeyun
Published: November 2023

There is a growing demand for the development of functional textile sanitary products to protect the human body from viruses, bacteria, and other harmful external substances. However, common processing methods for textile functionalization result in poor durability or have a highly limited material scope. A solution for this is the encapsulation of the functional material to provide stable protection and controlled release to reveal functionality in the fabric. However, many chemicals used for such purposes can cause problems for both human beings and the environment; therefore, attention is being shifted to natural products such as essential oils and seed oils. In this study, we used in situ polymerization to encapsulate ginseng oil, which has antibacterial, deodorizing, moisturizing, and antioxidant functions, as the core material of the microcapsules. The manufactured microcapsules were spherical with smooth surfaces, had an average size of 3.98 um, and exhibited excellent thermal stability. Processing the synthesized microcapsules into nylon/polyurethane fabric resulted in excellent functionalities, with the treated fabric exhibiting a 99.9% antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae and a 99% deodorizing effect. Therefore, the developed method is expected to show great potential for the production of highly hygienic textiles for use in various industries.
Challenges in Manufacturing of Hemp Fiber-Reinforced Organo Sheets with a Recycled PLA Matrix
Authors: Salmins Maximilian , Gortner Florian , Mitschang Peter
Published: November 2023

This study investigates the influence of a hot press process on the properties of hemp fiber-reinforced organo sheets. Plain-woven fabric made from hemp staple fiber yarns is used as textile reinforcement, together with a recycled poly-lactic acid (PLA) matrix. Process pressure and temperature are considered with three factor levels for each parameter. The parameter influence is examined based on the B-factor model, which considers the temperature-dependent viscosity of the polymer, as well as the process pressure for the calculation of a dimensionless value. Increasing these parameters theoretically promotes improvements in impregnation. This study found that the considered recycled polymer only allows a narrow corridor to achieve adequate impregnation quality alongside optimal bending properties. Temperatures below 170 °C impede impregnation due to the high melt viscosity, while temperature increases to 185 °C show the first signs of thermal degradation, with reduced bending modulus and strength. A comparison with hemp fiber-reinforced virgin polypropylene, manufactured with identical process parameters, showed that this reduction can be mainly attributed to polymer degradation rather than reduction in fiber properties. The process pressure should be at least 1.5 MPa to allow for sufficient compaction of the textile stack, thus reducing theoretical pore volume content to a minimum.
Nanofluids and Ionic Fluids as Liquid Electrodes: An Overview on Their Properties and Potential Applications
Authors: Pereira José , Souza Reinaldo , Moita Ana , Moreira António
Published: November 2023

The current review work focuses on recent developments in the exploration of electroactive nanofluids, ionanofluids, and ionic liquids acting as liquid electrodes. The nanofluids used for this purpose are composed of organic or aqueous electrolytes as base fluids with the addition of nanoparticles in pure, oxidized, or hybrid forms. On the other hand, the ionic liquids are formed by adding a solution, which can be an acid, a base, or a salt, in water. The electrochemical properties, such as electrical conductivity and capacitance, of these innovative fluids are discussed thoroughly, along with their influencing factors, such as the nature and concentration of the included nanoparticles, the type of base fluids, and the operating temperature. Moreover, this overview summarizes the fundamental applications of electroactive nanofluids, ionanofluids, and ionic liquids in various possible flow-cell configurations and electrolysis methods, along with the associated feasibility factors. Additionally, this survey of scientific papers on the matter enabled the listing and evaluation of general aspects related to the usage of electroactive nanofluids, ionanofluids, and ionic liquids. Finally, it addresses the main problems associated with such types of fluids and outlines the primary prospects for further research and utilization of electroactive nanofluids, ionanofluids, and ionic liquids in diverse scientific and technological fields.
A Design Method for Improving the Effect of Shale Interlaced with Limestone Reservoir Reconstruction
Authors: Lv Zefei , Chen Weihua , Wang Yang , He Rui , Liu Fei , Li Song
Published: November 2023

Sichuan Basin, located in southwestern China, is renowned for its abundant oil and gas resources. Among these valuable reserves, Da’anzhai seashell limestone stands out as a significant contributor to the region’s energy industry. Da’anzhai seashell limestone is a type of sedimentary rock that contains substantial amounts of organic matter. Over millions of years, the accumulation and transformation of this organic material have resulted in the formation of vast reservoirs rich in oil and natural gas. These reservoirs are found within the layers of Da’anzhai seashell limestone. The geological conditions in Sichuan Basin have played a crucial role in the development and preservation of these resources. The basin’s unique tectonic history has created favorable conditions for the generation and accumulation of hydrocarbon. Additionally, the presence of faults and fractures within the rock formations has facilitated fluid migration and trapping, further enhancing the resource potential. The exploitation of Da’anzhai seashell limestone resources has significantly contributed to China’s energy security and economic growth. Oil extracted from these reserves not only meets domestic demand, but also supports various industries such as transportation, manufacturing, and power generation. Natural gas derived from this source plays an essential role in heating homes, fueling industrial processes, and reducing greenhouse gas emissions by replacing coal as a cleaner-burning alternative. Efforts to explore and exploit Da’anzhai seashell limestone continue through advanced technologies such as seismic imaging techniques, horizontal drilling methods, and hydraulic fracturing (fracking), among others. These technological advancements enable more efficient extraction while minimizing the environmental impact. It is worth noting that sustainable management practices should be implemented to ensure the responsible utilization of these resources without compromising the ecological balance or endangering local communities. Environmental protection measures must be prioritized throughout all stages—exploration, production, transportation—to mitigate any potential negative impacts on ecosystems or water sources. In conclusion, the Sichuan Basin boasts abundant oil and gas resources, with Da’anzhai seashell limestone playing a vital role in supporting China’s energy needs. Through responsible exploration, extraction, and utilization practices, these valuable reserves can contribute positively towards national development while ensuring environmental sustainability.
“Add Teresa of Avila and Stir”—Why Adding Women Does Not End Exclusion Mechanisms in (Theological) Science
Authors: Werner Gunda
Published: November 2023

Knowledge production is by no means neutral; it perpetuates existing presuppositions and exclusions. Within Catholic theology, this is accentuated by particular structures and institutions. In this article, I will show that exclusions are not changed by simply ‘adding women’. I will proceed in four steps: First, I will examine the epistemic preconditions of knowledge production. Second, I will highlight concrete examples that show how several factors can change our reconstruction of theological history. This section will be organized around gender understandings in the premodern/Reformation era. Third, I argue for a specific understanding of theology which can be understood as a commentary on the respective context. Finally, I will summarize the conclusions with a concrete example. This article is situated in the context of the theological debates in the German-speaking world, which has a particular set of conditions for academic theology, such as the inclusion of theological faculties at state universities. However, it can certainly offer epistemic insights into postcolonial and gender-critical debates on theological contexts that are relevant beyond this specific context. Moreover, the article makes the current debate accessible to non-German-speaking audiences and in this way seeks to close ‘data gaps’ in international scholarship.
Prophylaxis Failure and Successful Management of Delayed-Onset Malaria with Renal Complications: A Case Report with Oral Artemether-Lumefantrine Treatment
Authors: Tolaj Ilir , Bunjaku Gramoz , Mehmeti Murat , Begolli Yllka
Published: November 2023

This case report presents a critical clinical scenario involving a 55-year-old patient who developed severe Plasmodium falciparum malaria with renal complications despite receiving doxycycline prophylaxis while traveling in a malaria-endemic region. The case emphasizes the potential failure of doxycycline prophylaxis and highlights the importance of considering malaria in patients with a history of travel to endemic areas, even if they have adhered to prophylactic treatment. The patient’s clinical presentation included fever, extreme fatigue, and loss of consciousness, leading to hospitalization. Laboratory findings revealed severe anemia, elevated liver enzymes, and impaired renal function, consistent with the criteria for severe malaria. The diagnosis was confirmed by the presence of Plasmodium falciparum parasites on thin blood smears. Due to limited access to parenteral antimalarial medications in Kosovo, the patient received oral artemether-lumefantrine, resulting in clinical improvement. Supportive care and dialysis played a vital role in the patient’s recovery. This case report underscores the need for increased awareness of prophylaxis failure, the challenges of managing severe malaria in non-endemic countries, and the importance of timely and appropriate interventions to improve outcomes in severe malaria cases, particularly those with renal involvement.
Fabrication of Origami Soft Gripper Using On-Fabric 3D Printing
Authors: Choi Hana , Park Tongil , Hwang Gyomin , Ko Youngji , Lee Dohun , Lee Taeksu , Park Jong-Oh , Bang Doyeon
Published: November 2023

In this work, we have presented a soft encapsulating gripper for gentle grasps. This was enabled by a series of soft origami patterns, such as the Yoshimura pattern, which was directly printed on fabric. The proposed gripper features a deformable body that enables safe interaction with its surroundings, gentle grasps of delicate and fragile objects, and encapsulated structures allowing for noninvasive enclosing. The gripper was fabricated by a direct 3D printing of soft materials on fabric. This allowed for the stiffness adjustment of gripper components and a simple fabrication process. We evaluated the grasping performance of the proposed gripper with several delicate and ultra-gentle objects. It was concluded that the proposed gripper could manipulate delicate objects from fruits to silicone jellyfishes and, therefore, have considerable potential for use as improved soft encapsulating grippers in agriculture and engineering fields.
Identifying the Drivers of Caribbean Severe Weather Impacts
Authors: Jury Mark R.
Published: November 2023

Severe weather impacts in the central Caribbean are quantified by an objective index of daily maximum wind and rainfall (W•R) in the area 16–19°N, 63–69°W over the period 1970–2021. The index, based on ERA5 hindcast assimilation of satellite and in situ data, peaks from the July to October season as high sea temperatures and weak wind shear promote tropical cyclogenesis. Climate forcing is studied by reducing the W•R index to seasonal values and regressing the time series onto reanalysis fields 10°S–25°N, 180°W–20°E. The outcome reflects Jul–Oct warming in the tropical Atlantic, cooling in the tropical east Pacific (cold tongue), decreased/increased convection over the Pacific/Atlantic, and tropical upper easterly winds. New findings emerge in the Mar–Jun season preceding higher W•R: reduced SW-cloud bands in the northeast Pacific, a convective trough over the equatorial Atlantic, and Caribbean cold-air outbreaks. The multivariate El Niño Southern Oscillation index correlates with Jul–Oct Caribbean W•R at 2-month lead time and shows growing influence. Composite analysis of the top-10 years identifies an anomalous Pacific–Atlantic Walker Circulation favoring higher Caribbean W•R. Salinity is below normal and heat flux is downward across the Atlantic. Anomalous low-level airflow inhibits upwelling in the SW Caribbean, deepening atmospheric moisture. A leading case (TC Fiona 2022) demonstrates the environmental conditions underpinning storm intensification. The key drivers of severe weather impacts yield guidance in strategic planning, risk management and disaster preparedness. New insights are gained from a localized index of severe weather.
A Bi-Radial Model for Lens Distortion Correction of Low-Cost UAV Cameras
Authors: Liebold Frank , Mader David , Sardemann Hannes , Eltner Anette , Maas Hans-Gerd
Published: November 2023

Recently developed cameras in the low-cost sector exhibit lens distortion patterns that cannot be handled well with established models of radial lens distortion. This study presents an approach that divides the image sensor and distortion modeling into two concentric zones for the application of an extended radial lens distortion model. The mathematical model is explained in detail and it was validated on image data from a DJI Mavic Pro UAV camera. First, the special distortion pattern of the camera was examined by decomposing and analyzing the residuals. Then, a novel bi-radial model was introduced to describe the pattern. Eventually, the new model was integrated in a bundle adjustment software package. Practical tests revealed that the residuals of the bundle adjustment could be reduced by 63% with respect to the standard Brown model. On the basis of external reference measurements, an overall reduction in the residual errors of 40% was shown.
Detection of AI-Created Images Using Pixel-Wise Feature Extraction and Convolutional Neural Networks
Authors: Martin-Rodriguez Fernando , Garcia-Mojon Rocio , Fernandez-Barciela Monica
Published: November 2023

Generative AI has gained enormous interest nowadays due to new applications like ChatGPT, DALL E, Stable Diffusion, and Deepfake. In particular, DALL E, Stable Diffusion, and others (Adobe Firefly, ImagineArt, etc.) can create images from a text prompt and are even able to create photorealistic images. Due to this fact, intense research has been performed to create new image forensics applications able to distinguish between real captured images and videos and artificial ones. Detecting forgeries made with Deepfake is one of the most researched issues. This paper is about another kind of forgery detection. The purpose of this research is to detect photorealistic AI-created images versus real photos coming from a physical camera. Id est, making a binary decision over an image, asking whether it is artificially or naturally created. Artificial images do not need to try to represent any real object, person, or place. For this purpose, techniques that perform a pixel-level feature extraction are used. The first one is Photo Response Non-Uniformity (PRNU). PRNU is a special noise due to imperfections on the camera sensor that is used for source camera identification. The underlying idea is that AI images will have a different PRNU pattern. The second one is error level analysis (ELA). This is another type of feature extraction traditionally used for detecting image editing. ELA is being used nowadays by photographers for the manual detection of AI-created images. Both kinds of features are used to train convolutional neural networks to differentiate between AI images and real photographs. Good results are obtained, achieving accuracy rates of over 95%. Both extraction methods are carefully assessed by computing precision/recall and F1-score measurements.
Anterior Lumbar Interbody Fusion (ALIF) for Lumbar Hemivertebra in an Adult Using Three-Dimensional-Printed Patient-Specific Implants and Virtual Surgery Planning: A Technical Report
Authors: Amin Tajrian , Parr William C. H. , Natarajan Pragadesh , Lennox Andrew , Koinis Lianne , Mobbs Ralph J.
Published: November 2023

Introduction: Hemivertebrae are a common defect of vertebral formation, potentially resulting in debilitating congenital scoliosis and necessitating highly traumatic surgery. Virtual surgical planning (VSP) and 3D-printed patient-specific implants (PSIs) have increasingly been applied to complex spinal surgery, and offer a range of potential benefits. Research Question: We report the use of 3D-printed PSIs and VSP as part of a two-level anterior lumbar interbody fusion (ALIF) for the management of lateral hemivertebra and congenital scoliosis. Material and Methods: A 53-year-old male with chronic low-back pain, due to L4 hemivertebra and mild congenital scoliosis, presented with new-onset leg pain. CT revealed L4/5 and L5/S1 degeneration and foraminal stenosis. Given the complex anatomy and extensive multi-level osteophytosis, 3D-printed PSIs were designed, manufactured, and implanted as part of a two-level ALIF. Results: Excellent implant fit was achieved intraoperatively, confirmed via postoperative imaging. VSP assisted with navigating challenging bony and vascular anatomy. Three-month postoperative imaging demonstrated construct stability, early signs of bony fusion, with implant placement, spinal curvature, and disc height corrections closely matching the VSP. Clinically, the patient’s pain and functional impairment had effectively resolved by nine-month follow up, as demonstrated through subjective and objective measures. Discussion and Conclusions: Virtual surgical planning and 3D-printed PSIs can be useful surgical aids in the management of the often-complex cases involving hemivertebrae and congenital scoliosis. This case of congenital pathology adds to the growing reports of PSI application to a variety of complex spinal pathologies, with analyses showing a close match of the postoperative construct to the preoperative VSP.
Circular Economy and Solid Waste Management: Connections from a Bibliometric Analysis
Authors: Reis Wender Freitas , Barreto Cristiane Gomes , Capelari Mauro Guilherme Maidana
Published: November 2023

The aim of this study is to conduct a meta-analysis of the research published between 2012 and 2022 on solid waste management (SWM) and the circular economy (CE) using bibliometrics. To this end, the Scopus and Web of Science (WoS) databases were used as sources of publications. Processing was conducted using the R language version 4.2.2 and the Bibliometrix software package version 4.1.2. A theoretical basis was built on the terms in order to present their interactions in the context of scientific debate. The results show that there is a need to create indicators to facilitate the evaluation of SWM. They can be identified from the data collected during the management process. Examples include the volume of material collected, operating costs, and recycling rates. Indicators are important in the waste management process because they help quantify the effectiveness of the management practices adopted, help to identify areas that need improvement, and make it possible to monitor the progress of work over time and the achievement of previously set targets. Two other important results are the maximization of the use of resources by increasing the useful life of the product and the emergence of new sustainable business models with recycling as a driving force. Finally, and perhaps the most disruptive discovery, is the integration of SWM and CE with blockchain technology to reduce the levels of waste production. This shows how new technologies can be used as partners in solving complex problems, such as solid waste (SW).
Understanding the Challenges Facing Decarbonization in the E-Commerce Logistics Sector in Latin America
Authors: Jurburg Daniel , López Agustina , Carli Isabella , Chong Mario , De Oliveira Leise Kelli , Dablanc Laetitia , Tanco Martín , De Sousa Paulo Renato
Published: November 2023

This article aims to analyze the opportunities related to improvement in the decarbonization strategies of the logistics sector, considering the economic, environmental, social, and technological challenges in four Latin American countries: Argentina, Brazil, Peru, and Uruguay. An original survey of 464 logistics companies involved in e-commerce in these four countries was carried out. From an economic point of view, companies have started to understand that being greener is not just a slogan but can be an opportunity for growth. The social pressure of customers for more sustainable supply chains forces companies to look for alternatives to reduce their environmental footprint. Finally, adding technology makes it possible to measure and monitor parameter indicators and look for alternatives to improve them (such as routing algorithms, electric vehicles, smart lockers, etc.). Decarbonization in the e-commerce logistics sector in Latin American countries still has room for improvement (for example, using metrics and electric vehicles) to match the levels of companies with similar characteristics in European, Asian, or North American countries.
The Predation of Pinna nobilis (Mollusca) Juveniles by the Spiny Sea Star Marthasterias glacialis (Echinodermata) in the Sea of Marmara
Authors: Çinar Melih Ertan , Bilecenoglu Murat
Published: November 2023

The critically endangered bivalve species, the pen shell Pinna nobilis, has been suffering from an epidemic disease in the Mediterranean Sea, and its populations have totally disappeared in many areas across the basin. The Sea of Marmara’s populations of the pen shell, which were previously assumed to have remained unaffected by the epidemic disease because of the special hydrographical condition of the sea (brackish water), have been devastated after the catastrophic mucilage event suddenly outburst in November 2020 in the region. The settlement of healthy juvenile specimens of the species was frequently observed in the area after the mucilage event. However, an unexpected predator of juvenile specimens of the pen shell, the spiny sea star Marthasterias glacialis, was encountered in the area in January 2023. Two cases were observed and the spiny sea star has a capability of crashing one valve of the sea-pen through which it consumes its flesh. This predation might have the potential to affect populations of P. nobilis, which has been struggling to survive in the region after its mass mortality due to the mucilage event. Such data are of utmost importance to imply effective conservation planning for the sustainability of the remaining populations of the pen shell in the region.
Minimizing Carbon Dioxide Emissions with Clinoptilolite Zeolite in Moris Pineapple Cultivation on Drained Sapric Soils
Authors: Choo Liza Nuriati Lim Kim , Ahmed Osumanu Haruna , Sekot Shamsiah , Shahlehi Syahirah
Published: November 2023

Drained tropical peat soils for agriculture emit more carbon dioxide (CO2) into the atmosphere from their stored carbon compared with their pristine state. Field and laboratory experiments were conducted to assess whether the natural zeolite of the clinoptilolite (ZeoC) species could be included in the pineapple fertilization program to decrease the CO2 emissions from tropical sapric soils. The static closed-chamber and laboratory incubation methods were used to determine the effects of ZeoC on the CO2 emitted from a drained sapric soil planted with Moris pineapple. The treatments assessed were as follows: (a) suggested ratio of ZeoC (5 g, 10 g, 14 g, and 20 g of ZeoC) and 20 g compound NPK 30:1:32 fertilizer, enumerated based on the pineapple plant requirement; (b) 20 g of compound NPK 30:1:32 fertilizer only; and (c) unfertilized sapric soils. The drained sapric soils amended with ZeoC (rate of 5 g to 20 g/plant) minimized the CO2 emissions compared with those without the ZeoC, because of the physical and chemical sorption of organic compounds and polar CO2 onto the lattices of ZeoC, which inhibited organic matter decomposition. ZeoC fertilization reduces sapric soil acidity and improves Moris pineapple fruit quality attributes and yield. Monthly pineapple fertilization with ZeoC at the vegetative and flowering phases is an alternative agronomic strategy to reduce CO2 emissions. This approach does not reduce pineapple yield on drained tropical sapric soils.
Ignored Opinions: Villager-Satisfaction-Based Evaluation Method of Tourism Village Development—A Case Study of Two Villages in China
Authors: Liu Naifei , Yue Kaijian , Zhang Xiaoyue
Published: November 2023

The neglect of endogenous strength is one of the reasons for the lack of sustainability in mountainous rural development and tourism development in China at present. How to incorporate the opinions of villagers in the tourism development process led by the government and other external entities is the main focus of this article. Based on the fieldwork of two typical mountainous villages and a previous rural development evaluation method, this article proposes the villager-satisfaction-based evaluation method for tourism village development, covering rural settlement construction, village esthetics, and economic and social development. “Villager satisfaction” is a crucial indicator obtained by objectifying the subjective opinions of villagers. Finally, the evaluation method was applied in the form of a questionnaire in two villages. The experimental results are correlated with the tourism development patterns of the two villages, verifying the feasibility and effectiveness of the evaluation method. It is expected that this evaluation method will become an effective communication medium between non-professional villagers and the professional tourism development process, thereby promoting the sustainable development of rural areas in the future.
Use of the Box–Behnken Experimental Design for the Optimization of Orange II (Acid Orange 7) Adsorption on Aloe vera
Authors: Aguilar María Isabel , Lloréns Mercedes , Ortuño Juan Francisco , Meseguer Víctor Francisco , Pérez-Marín Ana Belén , Cases Alejandro
Published: November 2023

Industrial wastewater effluents containing dyes are considered to pollute and be harmful to the environment. Among the various removal techniques, the adsorption process using low-cost adsorbents has been successfully used to remove pollutants. In this work, Aloe vera leaves (AVs) have been used as adsorbent for the removal of Orange II (O-II). A three-level three-factor Box–Behnken factorial design, including three replicates of center points, was applied to investigate the main parameters affecting the biosorption of O-II dye in aqueous solutions by AVs. The selected parameters were adsorbent dose, initial dye concentration, and contact time. The Box–Behnken experiment design has given a satisfactory result for the optimization of the adsorption process. The obtained value of R2 (0.9993) shows that the quadratic response model adequately represents the relationship between each response and the chosen variables. The pH influences the adsorption capacity, obtaining at pH 2 the maximum adsorption capacity value. From the kinetic models studied, the one that best describes the adsorption of Orange II on Aloe vera is the Bangham model (ARE = 1.06%). The isotherm model that best represents the experimental data is the Toth model. The maximum adsorption capacity obtained by this model was 15.9 mg·g−1.
Future Travel Intentions in Light of Risk and Uncertainty: An Extended Theory of Planned Behavior
Authors: Erul Emrullah , Woosnam Kyle Maurice , Salazar John , Uslu Abdullah , Santos José António C. , Sthapit Erose
Published: November 2023

COVID-19 has affected travel and will undoubtedly impact how people view travel and future intentions to travel as we adjust to life moving forward. Understanding how people arrive at these travel intentions will be paramount for managers and planners in determining how best to reactively and proactively plan for tourism, especially considering perceived risk and uncertainty related to COVID-19. By extending the theory of planned behavior, this study aims to examine the relationship between perceived risk, perceived uncertainty, subjective norms, attitudes about future travel, and perceived behavioral control in explaining individuals’ intentions to travel in the near future. This study employed a quantitative research method, and data were gathered using an online questionnaire distributed through Qualtrics from a sample of 541 potential travelers (representing residents of 46 US states) from 23 June 2020 to 1 July 2020. Of the eight hypotheses tested, four were supported. Surprisingly, neither perceived risk nor uncertainty were significant within the model. Subjective norms significantly predicted both attitudes about traveling and perceived behavioral control. Subjective norms and perceived behavioral control, in turn, explained a moderate degree of variation in individuals’ intentions to travel. Study implications, limitations, and future research suggestions are offered. One of the main managerial implications includes the need for destinations to be proactive and focus on intentional planning for sustainable tourism.
Optimization of a Tree Pit as a Blue–Green Infrastructure Object
Authors: Novak Lukas , Kabelkova Ivana , Hora David , Stransky David
Published: November 2023

Trees in dense urban environments are often planted in bioretention cells with an underlying trench (BC-T) providing both stormwater pretreatment and storage. The BC-T design is based on a water balance; however, some input data (tree water uptake and water-holding capacities of soil filter and trench substrate) are difficult to obtain. The goals of this paper were (i) to study the sensitivity of such data in the BC-T design (i.e., their effect on the size of the drained area which may be connected to the tree pit), and (ii) to recommend a possible simplification of the water balance for engineering practice. Global sensitivity analysis was performed for the setup of a BC-T used in Prague, Czech Republic, assuming three different trench exfiltration rates. The most sensitive variable affecting the size of the drained area is the available water-holding capacity in the trench. The simplification of the water balance is highly dependent on exfiltration conditions. At high exfiltration rates (18 mm·h−1 and more) or for a trench with an underdrain, the water-holding capacity in the soil filter and the tree water uptake can be omitted; whereas, at low trench exfiltration rates (1.8 mm·h−1, without an underdrain), both the water-holding capacity of the trench substrate and the potential tree water uptake have a significant influence and cannot be omitted.
Spatiotemporal Changes and the Prediction of Drought Characteristics in a Major Grain-Producing Area of China
Authors: Guo Linghui , Luo Yuanyuan , Li Yao , Wang Tianping , Gao Jiangbo , Zhang Hebing , Zou Youfeng , Wu Shaohong
Published: November 2023

Understanding variations in drought characteristics is of great importance for water resource planning and agriculture risk management. Despite increasing interest in exploring spatiotemporal drought patterns, long-term drought event characteristics and their future changes are unclear in major grain-producing areas in China. In this study, we applied Run theory, Sen’s slope, the modified Mann–Kendall method, wavelet analysis, and three machine learning models to systematically examine drought variation patterns, their future trends, and agricultural exposure in Henan Province, China, from 1961 to 2019. The results indicated that the SPEI-12 showed a significant increase at a rate of 0.0017/month during 1961–1999, but this has gradually changed to a drying trend since the 21st century. Drought event characteristics shifted markedly during these two periods, with drought duration and severity gradually shifting from east to west. The BO-LSTM model performed better than the LSTM and BP models, indicating that the drought frequency, higher drought duration, and drought peak would greatly increase 1.28–3.40-fold and cropland exposure is predicted to increase 1.61-fold in the near future compared to the first two decades of the 21st century. This finding not only helps developing meteorological drought predicting models, but also provides the scientific groundwork for drought disaster prevention and mitigation in Henan Province.