bluuebunny/crossref_metadata_2025 huggingface dataset:
Uncoupling Sae2 Functions in Downregulation of Tel1 and Rad53 Signaling Activities
Authors: Colombo Chiara Vittoria , Menin Luca , Ranieri Riccardo , Bonetti Diego , Clerici Michela , Longhese Maria Pia
Published: December 2018

The Mre11-Rad50-Xrs2 (MRX) complex acts together with the Sae2 protein to initiate resection of DNA double-strand breaks (DSBs) and to regulate a checkpoint response that couples cell cycle progression with DSB repair. Sae2 supports resistance to DNA damage and downregulates the signaling activities of MRX, Tel1, and Rad53 checkpoint proteins at the sites of damage. How these functions are connected to each other is not known. Here, we describe the separation-of-function sae2-ms mutant that, similar to SAE2 deletion, upregulates MRX and Tel1 signaling activities at DSBs by reducing Mre11 endonuclease activity. However, unlike SAE2 deletion, Sae2-ms causes neither DNA damage sensitivity nor enhanced Rad53 activation, indicating that DNA damage resistance depends mainly on Sae2-mediated Rad53 inhibition. The lack of Sae2, but not the presence of Sae2-ms, impairs long-range resection and increases both Rad9 accumulation at DSBs and Rad53–Rad9 interaction independently of Mre11 nuclease activity. Altogether, these data lead to a model whereby Sae2 plays distinct functions in limiting MRX-Tel1 and Rad9 abundance at DSBs, with the control on Rad9 association playing the major role in supporting DNA damage resistance and in regulating long-range resection and checkpoint activation.
IS PSYCHOSOMATIC REALLY A BICENTENNIAL WORD? THE PROOF OF AN OLDER USE
Authors: Dumitrascu Dan L. , David Liliana , Baban Adriana
Published: December 2018

Background and aim. Psychosomatic medicine has different statuses in different countries and many physicians perceive it under various points of view. However, a common belief is that the father of the word psychosomatic is the German physician Johann Heinroth and that the word was coined in 1818. We looked for the history of the word psychosomatic to find out if this information is correct or not.Methods. The available literature was searched online and manually. We recorded available information and looked for other pertinent mentions of this word before 1818.Results. Although it is considered that the word psychosomatic is 200 years old, we found evidence that it had been used also in advance. Thus, the history of psychosomatic medicine is even longer. Here is the first report of a scientific work older than 1818. It is a PhD thesis published in Montpellier in 1784 by Marc Lemort Demétigny.Conclusions. The general belief is that the first use of the word psychosomatic happened 200 years ago. We found evidence that the word has an older usage.
Atropellamientos de fauna silvestre en la red vial urbana de cinco ciudades del Valle de Aburrá (Antioquia, Colombia)
Authors: Bedoya-V María Margarita , Árias-Alzate Andrés , Delgado-V. Carlos Andres
Published: December 2018

En este estudio se documentan y analizan los casos de atropellamiento de fauna silvestre encontrados en el área urbana del Valle de Aburrá comprendida por los municipios metropolitanos de Bello, Medellín, Itagüí, Envigado y Caldas, con el objetivo de conocer las especies más afectadas, la efectividad de las señales preventivas instaladas y las variables que pueden tener influencia sobre este fenómeno. Se analizaron datos colectados de manera aleatoria con el aplicativo TAyRA, junto con datos obtenidos por el monitoreo periódico por dos vías principales del valle. Se encontró que los animales más afectados son las aves y los mamíferos, y que el límite de velocidad, el ancho de la vía y la distancia a las zonas verdes son factores de influencia. Adicionalmente se calculó una tasa de atropellamiento aproximada de 0,2 ind/km de vía urbana/semana. Se sugiere la ubicación de señales de tránsito para la prevención de atropellamiento de fauna y disminuir los impactos que las vías tienen en la fauna silvestre urbana.
Irritábilisbél-szindróma: komorbid pszichiátriai zavarok és pszichológiai kezelési lehetőségek
Authors: Gajdos Panna , Rigó Adrien
Published: December 2018

Abstract:

Irritable bowel syndrome is a chronic functional gastrointestinal disorder with a prevalence of 7–21%. It has a negative impact on health-related quality of life and work productivity and it is associated with increased psychological distress and mental comorbidity, like major depression disorder and generalised anxiety disorder. Due to biopsychosocial factors and the brain-gut axis playing a key role in the aetiology of the disease, the use of psychological treatments has great importance in the therapy of irritable bowel syndrome. These interventions focus on central mechanisms, like visceral sensitivity, pain amplification, hypervigilance and gastrointestinal symptom-specific anxiety. They significantly reduce damaging illness-related cognitions, the use of maladaptive coping strategies, catastrophic appraisals of bodily sensations and chronic muscle tension. The utilization of these treatments is associated with clinically significant symptom improvement and positive mental health outcomes. This review study focuses on the psychiatric comorbidity of irritable bowel syndrome and the use of evidence-based psychological therapies in the treatment of the disease. Using ScienceDirect and PubMed databases, almost 60 studies have been selected. A high number of studies investigate the efficacy of cognitive behaviour therapy and hypnotherapy with meta-analyses included. There is also growing evidence on the beneficial impacts of mindfulness-based stress reduction. Future research will need to concentrate on studying the utility of mind-body therapies such as relaxation techniques in the treatment of irritable bowel syndrome with meta-analyses on the effects of mindfulness-based interventions. Orv Hetil. 2018; 159(50): 2115–21121.
Checklist of the Myriapoda in Cretaceous Burmese amber and a correction of the Myriapoda identified by Zhang (2017)
Authors: Wesener Thomas , Moritz Leif
Published: December 2018

An inventory of the Myriapoda (Diplopoda, Chilopoda, Symphyla) from Cretaceous Burmese amber, Myanmar, is presented, including the oldest and/or first fossil record for numerous orders. For millipedes (Diplopoda) 527 records, including 460 new specimens determined by us, belonging to 13 of 16 recent orders are listed: Polyxenida, Glomeri­desmida, Glomerida, Siphonophorida, Polyzoniida, Platydesmida, Siphoniulida, Chordeumatida, Polydesmida, Stemmiulida, Callipodida, Spirostreptida and Spirobolida. For centipedes, 33 records for 4 of the 5 recent orders are listed: Scutigero­morpha, Lithobiomorpha, Scolopendromorpha and Geophilomorpha. For Symphyla, three records for both families, Scutigerellidae and Scolopendrellidae, are listed. The majority of Diplopoda records (30.5%) are Polydesmida. The record of the Polyzoniida includes first instar octopod juveniles. The checklist includes the first fossil representatives known of the Platydesmida, as well as the oldest known fossils of the Polyxenida, Glomeridesmida, Glomerida, Siphono­phorida, Polyzoniida, Siphoniulida, Spirostreptida, as well as both Symphyla families. Misidentifications by Zhang (2017) are corrected; while most Chilopoda in that list are correct, almost all Diplopoda are misidentified.
STUDY ON INSPECTION OF THE PUTATIVE HYBRIDS BETWEEN TRACK-LACKING WILD MALE GAUR (BOS GAURUS) AND DOMESTIC FEMALE COW (BOS TAURUS) IN PHUOC BINH NATIONAL PARK, VIETNAM
Authors: Duc Le Hoang , Tung Pham Thanh , Nam Nguyen Trung , Ha Chu Hoang , Tham Le Xuan , Son Le Van
Published: December 2018

Hybridization between wild and domestic bovine occurs widely due to the overlapping of the natural habitat of the wild and human farm animals. Due to the loss of habitat, the number of wild gaur (Bos gaurus) in Vietnam was in serious decline. Since 2009, a male wild gaur (Bos gaurus) has appeared and incorporated with female domestic cows (Bos taurus) in buffer zone Phuoc Binh National Park, on the border with Lam Dong and Ninh Thuan provinces. Then, several calves were born that carried some traits of wild gaur including physical characteristics and behaviors. These calves were supposed to be offspring between wild gaur and domestic cows. In previous study, the karyotypes of putative calves were identified with 2n = 58 and non-homologous chromosome 28 and 29 in these hybrids. In this study, we characterized the putative hybrids between track-lacking Bos gaurus and Bos taurus for breeding and preservation using Cytochrome b analysis, microsatellites and a novel marker growth hormone factor 1 (POU1F1). Cytochrome b analysis indicated the maternal lineage of the putative hybrids, with 100% nucleotide sequence identity. Microsatellite BM861 and sequence of ZFY gene region reveal Bos taurus chromosome Y origin was among the male putative hybrids. Importantly, the analysis of POU1F1 gene sequence on 1 chromosome showed efficacy in determining both Bos gaurus and Bos taurus lineage in the putative hybrids. The karyotyping results were confirmed by molecular analysis and our results provide a feasible way for detecting the putative hybrids between wild and domestic cattle in case of lacking the wild trace.
FIRST RECORD OF CANTHARELLUS MINOR IN VIETNAM
Authors: Phan Hung Huu , Lao Thuan Duc , Ai Le Thuy Huyen , Hoang Khanh Quoc , Truong Nguyen Binh , Lam Ngo Giang Thi
Published: December 2018

This species of mushroom with orange fruiting bodies and yellow flesh grows in clumps on the forest land in the coordinates 11o56'34.45" N, 108o28'33.56" E in the pine (Pinus kesiya) forest, Da Lat City, Lam Dong Province, Vietnam. The results of analysis on the morphology, both macro- and micro-morphological characteristics of this mushroom showed that, pileus: 5-15 mm wide, infundibuliform; yellowish to orange; margin incurred, wavy-liked margin, non-striate; Pileus surface: smooth, scaleless, yellowish; Lamellae: distant, decurrent, not intervenose, concolorous to pileus; Context: concolourous to the pileus, slight sweetness, aromatic flavor; Stipe: cylindrical shape, surface smooth, concolourous to pileus, 1-2 mm diameter, 20-50 mm length; Basidiospores: 6-11.5 x 4-6.5 μm, ovoid-ellipsoid with smooth surface; Basidia: 65 x 10 μm, cornuted 4-6 spores per basidium. Phylogenetic analysis of nrLSU sequence yielded consistent topology in different taxa of Cantharellus. The phylogenetic position of XC02 was obtained and accepted at sub-generic level: subgenus Parvocantharellus. This clade was suggested to be monophyletic, and separated from other sub-generic levels. Morphologically phylogenetically distinct from the other species of clade 4, such as C. appalachiensis, C. tabernensis, C. aff. Congolensis. The highly supported monophyletic group with referent Cantharellus minor was obtained with the bootstrap value of 99, indicated that XC02 was significant closely to Cantharellus minor. Phylogenetic of nrLSU analysis revealed clades with statistical support corresponding to morphological observation, thus, XC2 was concluded as Cantharellus minor.
INFLUENCE OF CULTIVATION OF CHLORELLA VULGARIS ON MICROORGANISMS IN SEAFOOD WASTEWATER
Authors: Dong Phuong Nguyen Thi , Ngoc Thu Tran Thi , Van Anh Le Thi , Phuoc Trang Nguyen Huu
Published: December 2018

Microalgae cultivation in wastewater for many purposes has been investigated recently decade ago. In this study, Chlorella vulgaris was chosen to culture for examination of its influences on microorganisms of seafood wastewater in particular aerobic bacteria, Coliform and E. coli. The microalgae cultivation was realized in Erlenmeyer flasks containing seafood wastewater medium. Another was also grown in original medium called Sueoka medium for control. All experiments were set up until almost all Chlorella vulgaris decanted or flocculated in the bottom of flasks. The changes of bacteria counts including aerobic bacteria, Coliform and E. coli were measured to evaluate the impact of cultivation of Chlorella vulgaris on them in this sewage. Otherwise, the growth of microalgae has been also recorded for evaluating the effect of a new medium on metabolism of Chlorella vulgaris. The results showed that the bacteria counts were significantly reduced after day 3 of microalgae culture. These results have been calculated the efficiency of aerobic bacteria, Coliform and E. coli elimination out of wastewater medium represented approximately 70%, 81% and 90% respectively. These eliminations provided evidences of difficult metabolism of bacteria under the presence of microalgae as like as Chlorella vulgaris. In other words, the symbiosis of microalgae and bacteria in sewage could prevent the raising of bacteria counts.
Ultraviolet Functionalization Improved Bone Integration on Titanium Surfaces by Fluorescent Analysis in Rabbit Calvarium
Authors: Liu Weizhen , Du Bing , Zhou Lei , Wang Qin , Wu Jingyi
Published: December 2018

This study evaluated the effect of ultraviolet functionalization (UV) on bone integration ability in rabbit model, using epifluorescence microscopy. Each of 12 rabbits (n = 6) received randomly four titanium domes prepared with or without ultraviolet for 48 hours (UVC, λ = 250 ± 20 nm; Philips, Tokyo, Japan): (1) turned surface (T), (2) turned surface with UV (T-UV), (3) sandblasted (120 μm aluminum oxide) and etched by 18% hydrochloric acid and 49% sulphuric acid at 60°C for 30 min (SLA) and (4) SLA surface with UV (SLA-UV). Fluorochrome bone labels were marked by oxytetracycline at 25 mg/kg on 13th days and 14th days and calcein at 5 mg/kg on 3th days and 4th days before euthanization. The study samples were sacrified at 2 weeks and 4 weeks. The undecalcified specimens were prepared. The newly formed total bone of cross-sectional area (TB, %), the mineralized trabecular bone of cross-sectional area (MB, %), and the new bone and dome contact (BDC, %) were measured and analyzed by fluorescence microscope and Image Pro Express 6.0. The data of MB and TB showed new bone regeneration was increased in all groups, but no signs of difference were found. However, the means BDC of UV treatment on turned surface at 4 weeks, the UV treated on SLA surface at 2 weeks and 4 weeks were statistically significantly higher than the control group (P < .05). Within the limitations of the study, it can be concluded that ultraviolet functionalization on the titanium surface could enhance the new bone tissues and titanium surface integration.
Intervertebral disc herniation in two coatis (Nasua nasua) and postoperative laminectomy membrane formation
Authors: Fehr Michael , Neßler Jasmin , Schütter Alexandra , Dziallas Peter , Molnár Viktor , Ludwig Carsten , Zabke Sarah , Lehmbecker Annika , Tipold Andrea , Meyerhoff Nina
Published: December 2018

Magnetic resonance imaging revealed spinal cord compression due to intervertebral disc herniation of Hansen type I and II in the thoracolumbar vertebral column in two middle-aged coatis (Nasua nasua) with chronic progressive paraparesis. Surgical treatment included hemilaminectomy and partial corpectomy in one and dorsal laminectomy in the other coati. Both coatis recovered well after surgery. One showed unremarkable gait 6 and 15 months post surgery, while the other one suffered from recurrence of paraparesis leading to euthanasia because of deterioration of neurological signs 20 months after the first surgery. Necropsy revealed formation of a laminectomy membrane compressing the spinal cord. Histopathological signs of spinal cord injury and findings of degenerative processes in the intervertebral disc were comparable to those described in dogs. In conclusion, this case report shows for the first time that surgical intervention seems to be a useful and safe treatment in chronic intervertebral disc herniation in coatis, but relapses are possible.
Kitap Tanıtımı: Tefsîru Âyeti “Zahera’l-Fesâdu fi’l-Berri ve’l-Bahr”
Authors: BALTACI Burhan
Published: December 2018

Saraybosna Gazi Hüsrev Kütüphanesi El Yazması
eserler 3655/2 nu.da vr. 51b-54a’da 
kayıtlı Yazma Ayet Tefsiri isimli eser Rum suresi 30/41. ayetin tefsiridir.
FDA Approval Summary: Atezolizumab or Pembrolizumab for the Treatment of Patients with Advanced Urothelial Carcinoma Ineligible for Cisplatin-Containing Chemotherapy
Authors: Suzman Daniel L. , Agrawal Sundeep , Ning Yang-min , Maher V. Ellen , Fernandes Laura L. , Karuri Stella , Tang Shenghui , Sridhara Rajeshwari , Schroeder Jason , Goldberg Kirsten B. , Ibrahim Amna , McKee Amy E. , Pazdur Richard , Beaver Julia A.
Published: December 2018

The U.S. Food and Drug Administration (FDA) granted accelerated approval to atezolizumab and pembrolizumab in April and May 2017, respectively, for the treatment of patients with locally advanced or metastatic urothelial carcinoma who are not eligible for cisplatin-containing chemotherapy. These approvals were based on efficacy and safety data demonstrated in the two single-arm trials, IMvigor210 (atezolizumab) and KEYNOTE-052 (pembrolizumab). The primary endpoint, confirmed objective response rate, was 23.5% (95% confidence interval [CI]: 16.2%–32.2%) in patients receiving atezolizumab and 28.6% (95% CI: 24.1%–33.5%) in patients receiving pembrolizumab. The median duration of response was not reached in either study and responses were seen regardless of PD-L1 status. The safety profiles of both drugs were generally consistent with approved agents targeting PD-1/PD-L1. Two ongoing trials (IMvigor130 and KEYNOTE-361) are verifying benefit of these drugs. Based on concerning preliminary reports from these trials, FDA revised the indications for both agents in cisplatin-ineligible patients. Both drugs are now indicated for patients not eligible for any platinum-containing chemotherapy or not eligible for cisplatin-containing chemotherapy and whose tumors/infiltrating immune cells express a high level of PD-L1. The indications for atezolizumab and pembrolizumab in patients who have received prior platinum-based therapy have not been changed. This article summarizes the FDA thought process and data supporting the accelerated approval of both agents and the subsequent revision of the indications.

Implications for Practice

The accelerated approvals of atezolizumab and pembrolizumab for cisplatin-ineligible patients with advanced urothelial carcinoma represent the first approved therapies for this patient population. These approvals were based on single-arm trials demonstrating reasonable objective response rates and favorable durations of response with an acceptable toxicity profile compared with available non-cisplatin-containing chemotherapy regimens. However, based on concerning preliminary reports from two ongoing phase III trials, the FDA revised the indication for both agents in cisplatin-ineligible patients. Both are now indicated either for patients not eligible for any platinum-containing chemotherapy or not eligible for cisplatin-containing chemotherapy and whose tumors have high expression of PD-L1.
Phase II Randomized Trial of Sequential or Concurrent FOLFOXIRI-Bevacizumab Versus FOLFOX-Bevacizumab for Metastatic Colorectal Cancer (STEAM)
Authors: Hurwitz Herbert I. , Tan Benjamin R. , Reeves James A. , Xiong Henry , Somer Brad , Lenz Heinz-Josef , Hochster Howard S. , Scappaticci Frank , Palma John F. , Price Richard , Lee John J. , Nicholas Alan , Sommer Nicolas , Bendell Johanna
Published: December 2018

Background

First-line treatment for metastatic colorectal cancer (mCRC) typically entails a biologic such as bevacizumab (BEV) with 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) or 5-fluorouracil/leucovorin/irinotecan (FOLFIRI). STEAM (NCT01765582) assessed the efficacy of BEV plus FOLFOX/FOLFIRI (FOLFOXIRI), administered concurrently (cFOLFOXIRI-BEV) or sequentially (sFOLFOXIRI-BEV, FOLFOX-BEV alternating with FOLFIRI-BEV), versus FOLFOX-BEV for mCRC.

Patients and Methods

Patients with previously untreated mCRC (n = 280) were randomized 1:1:1 to cFOLFOXIRI-BEV, sFOLFOXIRI-BEV, or FOLFOX-BEV and treated with 4–6-month induction followed by maintenance. Coprimary objectives were overall response rate (ORR; first-line cFOLFOXIRI-BEV vs. FOLFOX-BEV) and progression-free survival (PFS; pooled first-line cFOLFOXIRI-BEV and sFOLFOXIRI-BEV vs. FOLFOX-BEV). Secondary/exploratory objectives included overall survival (OS), liver resection rates, biomarker analyses, and safety.

Results

ORR was 72.0%, 72.8%, and 62.1% and median PFS was 11.9, 11.4, and 9.5 months with cFOLFOXIRI-BEV, sFOLFOXIRI-BEV, and FOLFOX-BEV, respectively. OS was similar between arms. ORR between cFOLFOXIRI-BEV and FOLFOX-BEV did not significantly differ (p = .132); thus, the primary ORR endpoint was not met. cFOLFOXIRI-BEV and sFOLFOXIRI-BEV numerically improved ORR and PFS, regardless of RAS status. Median PFS was higher with pooled concurrent and sequential FOLFOXIRI-BEV versus FOLFOX-BEV (11.7 vs. 9.5 months; hazard ratio, 0.7; 90% confidence interval, 0.5–0.9; p < .01). Liver resection rates were 17.2% (cFOLFOXIRI-BEV), 9.8% (sFOLFOXIRI-BEV), and 8.4% (FOLFOX-BEV). Grade ≥ 3 treatment-emergent adverse events (TEAEs) were observed in 91.2% (cFOLFOXIRI-BEV), 86.7% (sFOLFOXIRI-BEV), and 85.6% (FOLFOX-BEV) of patients, with no increase in serious chemotherapy-associated TEAEs.

Conclusion

cFOLFOXIRI-BEV and sFOLFOXIRI-BEV were well tolerated with numerically improved ORR, PFS, and liver resection rates versus FOLFOX-BEV, supporting triplet chemotherapy plus BEV as a first-line treatment option for mCRC.
Hierarchical Bayesian modelling of geotechnical data: application to rock strength
Authors: Bozorgzadeh Nezam , Harrison John P. , Escobar Michael D.
Published: December 2018

With the introduction and revisions of geotechnical limit states design (LSD) standards such as Eurocode 7, rock engineering design is moving towards reliability-based design, a method for which statistical characterisation of design parameters is essential. However, the often limited project-specific data in rock engineering do not allow straightforward application of classical statistical analyses, and thus alternative approaches are required. In this paper, hierarchical Bayesian modelling is first introduced as a means of logically combining data from different sources to augment limited project-specific data. A Bayesian hierarchical non-linear regression model for the analysis of rock strength data is then developed and implemented; it is applied to 40 strength data sets of granite retrieved from the literature. In the context of these data, the advantages of the hierarchical model and the improvements in strength parameter estimations brought about by its application are discussed. Also discussed is the goodness-of-fit of the hierarchical model in comparison with more conventional statistical models. The paper concludes with suggestions for further development of the proposed hierarchical model, and the potential of hierarchical modelling as a general approach to statistical modelling of geotechnical data.
O controle de convencionalidade do crime de desacato e o sistema interamericano de direitos humanos na redemocratização na américa-latina: uma análise com base no caso brasileiro.
Authors: Ferraço André Augusto Giuriatto , Moraes Gabriela Garcia Batista Lima
Published: December 2018

O artigo apropria-se da análise do controle de convencionalidade sobre o crime de desacato, utilizando-se do entendimento da Comissão e da Corte Interamericana de Direitos Humanos, assim como do recente entendimento do Superior Tribunal de Justiça brasileiro no que diz respeito ao tema. Evidencia o funcionamento do Sistema Interamericano de Direitos Humanos para, então, abordar o controle de convencionalidade e a posição do STJ em comparação aos órgãos do Sistema. Propõe-se que a inconvencionalidade do crime de desacato no Brasil contribui para redemocratização da América Latina, frente ao deficiente processo de justiça de transição.
Mulheres, política e (sub) representação feminina: a ADI 5617 e as ações afirmativas para assegurar a participação feminina mínima nas casas legislativas
Authors: Bambirra Felipe Magalhaes , Marques Milene De Souza
Published: December 2018

No Brasil, foi apenas no século XX que as mulheres puderam, legalmente, votar e serem votadas, havendo este direito se consolidado, de modo definitivo, com a Constituição Federal de 1988. Contudo, o déficit representativo feminino continua acentuado: as mulheres ocupam menos de 12% dos das cadeiras dos parlamentos estaduais. Diante disto, o presente trabalho objetiva, a partir de uma metodologia crítico-propositiva, avaliar o atual cenário da participação feminina na política brasileira, considerando, em especial, as ações afirmativas promovidas e o julgamento da ADI 5617, adotando-se como hipótese a insuficiência do modelo de ação afirmativa existente, para, ao final, sugerir propostas capazes de, efetivamente, aumentar a representatividade feminina e diminuir este déficit democrático.
Visual perception of five-year-old Afrikaans-speaking children in Bloemfontein using the Beery VMI-6, DTVP-3 and TVPS-3: A follow up study of their English-speaking counterparts in Bloemfontein
Authors: Visser Marieta , Nel Mariette
Published: December 2018

BACKGROUND AND AIM: Previous research investigated the latest versions of the Beery-Buktenica Developmental Test of Visual-motor Integration 6th edition (Beery VMI-6), Development Test of Visual Perception 3rd edition (DTVP-3) and Test of Visual Perceptual Skills 3rd edition (TVPS-3) on five-year-old English-speaking children. This study aimed to extend the investigation, to five-year-old Afrikaans-speaking children, and to compare the results to previous findings on English-speaking children of a similar age. METHODS: A quantitative, cross-sectional investigation into the visual perception and visual-motor performance of five-year-old Afrikaans-speaking children (n=52) was conducted at Afrikaans Language of Learning and Teaching (ALOLT) schools in Bloemfontein, by using these tests according to the prescribed procedures, in a specific order and with adequate breaks between tests RESULTS: Both language groups' performance on the Beery VMI-6 and DTVP-3 compared well to the American normative sample, but below average on all the TVPS-3 composite scores. The Beery VMI-6 motor coordination sub-test yielded statistically significant gender differences. No significant language differences were noted in the three tests. A statistically significant difference was identified between form constancy and visual closure sub-tests of the DTVP-3 and the TVPS-3, and when the Beery VMI-6 visual-motor integration sub-test was compared to the DTVP-3copying sub-test CONCLUSIONS: Occupational therapists are encouraged to consider the suitability of the three tests, and further research in this field is recommended Key words: visual perceptual tests; visual-motor performance; five-year-old children; Beery VMI-6; DTVP-3; TVPS-3
YURTDIŞI TEMİNAT MEKTUPLARININ NAKDE ÇEVRİLMESİ SİGORTASI, İHRACATA ETKİSİ VE UYGULAMA ÖRNEKLERİNİN DEĞERLENDİRİLMESİ
Authors: YEŞİLYAPRAK Mehmet
Published: December 2018

Bu çalışmanın amacı “teminat mektuplarının
nakde çevrilmesi sigorta/garanti” ürününü ve bu ürünün ülke ihracatlarına
etkisini incelemektir. Bunun için, bu çalışmada birlikte öncelikle teminat
mektupları hakkında literatür çalışmasına yer verilmiştir. Sonrasında ise
teminat mektuplarının nakde çevrilmesi sigorta/garanti ürününün literatürde
nasıl ele alındığına açıklanmıştır. Bir sonraki aşamada bu sigorta/garanti
ürününü uygulayan ihracat destek kuruluşları hakkında bilgi verilmesi
amaçlanmıştır. Öte yandan, bu ihracat destek kuruluşlarının hangi şartlarla bu
ürünü ihracatçılarına temin edildiğine dair detaylar toplanmıştır. Ayrıca dört
örnek ihracat destek kuruluşu ele alınmış, bu ürünün uygulanan ülkelerde ülke
ihracatlarına ne kadar katkı sağladığı konusuna değinilmiştir. Verilere göre bu
ürünün genel olarak toplam ihracat içinde çok fazla yer almadığı sonucuna
varılmış ve sonuç olarak sigorta ürününün kullanıldığı alan ve sektörlere
yönelik daha detaylı bir analizin gerekliliğine kanaat getirilmiştir.
Újabb adat a hazai adventív flóra ismeretéhez: a Lactuca tatarica (L.) C.A. Mey. 1831 Magyarországon
Authors: Korda Márton , Kergyik Éva , Tóth Anna , Csiszár Ágnes
Published: December 2018

A szerzők beszámolnak az eurázsiai és észak-amerikai elterjedésű tatár saláta (Lactuca tatarica (L.) C.A. Mey.) első magyarországi előfordulásáról. Ismertetik a faj fontosabb taxonómiai, morfológiai, chorológiai, élőhelyi sajátosságait, illetve a természetvédelmi vonatkozásait. Őshonos elterjedési területén kívüli európai terjedése az 1800-as évek végén vette kezdetét. Az első jelentősebb ada­tok a Balti-, illetve az Északi-tenger partvidékéről származnak. Az 1920-as évektől Európa számos, a tengerektől távol eső pontján is megfigyelték jövevény fajként. Mivel előfordulása Szlovákia és Auszt­ria Magyarországhoz közeli területein évtizedek óta ismert, hazai előkerülése nem váratlan. Meglepő mó­don azonban nem az említett országokhoz közel, hanem Csongrád megye déli részén került elő 2018 augusztusában. A szomszédos országokhoz hasonlóan hazánkban is jellegtelen, bolygatott élőhelyen telepedett meg. A faj ökológiai igényeit, agresszív vegetatív terjedőképességét, illetve a külföldi tapasz­talatokat figyelembe véve további terjedése várható.
Inflammatory bowel diseases: course peculiarities and drug therapy in pregnant women. Lactation. Personal matters (by the materials of the second european consensus on reproduction and pregnancy in patients with inflammatory bowel diseases, 2015)
Authors: Khlynova O. V. , Sandakova E. A. , Zitta D. V. , Stepina E. A. , Koposova K. A. , Okisheva L. G.
Published: December 2018

The paper presents a continuation of discussion regarding personal matters on the course of inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (KD) in pregnant women, including the problems of basic drug therapy of the main disease both during pregnancy and lactation period. Separately, there are data on safety of conducted therapy, indications for surgical treatment and use of biological genetically engeneered drugs. The paper is based on the materials of “The Second European Consensus on Reproduction and Pregnancy in Patients with Inflammatory Bowel Diseases, 2015”. The main positions are presented according to the criteria of evidence-based medicine.
Express diagnosis of connective tissue dysplasia in conditions of ambulatory-polyclinic service
Authors: Denisov A. S. , Zagorak D. P.
Published: December 2018

Aim. To detect the most informative signs of connective tissue dysplasia (CTD) and develop the method for CTD express diagnosis in conditions of ambulatory and stationary traumatologo-orthopedic service.

Materials and methods. Sixty practically healthy persons were examined. To diagnose the connective tissue pathology, there were used the criteria developed by S.K. Evtushenko (2002), T.Yu. Smolnova (2003) and T.I. Kartunova (2006). Eighteen the most informative criteria were chosen.

Results. The paper is devoted to a widespread and yet not fully studied problem – the connective tissue dysplasia. The basic signs of this disease were analyzed. The most informative criteria of connective tissue dysplasia were singled out. Express test for primary diagnosis of this pathology in conditions of traumatologo-orthopedic service was offered.

Conclusions. Express test of the state of connective tissue structure is simple to perform. It can be used to improve surgical aids in connective tissue dysplasia, when additional stabilization of loco motor system is required.
Bir Hastanenin Aile Hekimliği Polikliniğine Başvuran Hastaların Sigara İçme Durumları: Ankara Örneği
Authors: UYSAL Zekai , HATİPOĞLU Ertuğrul
Published: December 2018

Amaç:Aile Hekimliği Polikliniğine başvuran hastaların sigara içme durumları ve nikotin bağımlılık seviyelerinin sosyo-demografik değişkenlerle arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntem:Bu kesitsel, niceliksel araştırmada uygunluk örneklemi kullanılmıştır. Bu araştırma 01.02.2018-01.04.2018 tarihleri arasında Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Aile Hekimliği Polikliniği’nde yürütülmüştür. Polikliniğe başvuran hastalar arasından, araştırmaya katılmayı kabul edenler ile görüşmeler yapılmıştır. Araştırmacılar verileri hastalarla yüz yüze görüşerek elde etmiştir. Verilerin toplanmasında demografik bilgi formu ve Fagerström Nikotin Bağımlılık Testi (FNBT) kullanılmıştır. Elde edilen veriler SPSS v. 20 programı ile araştırmanın amacı doğrultusunda incelenmiştir. Sürekli değişkenler ortalama ya da standart sapma, kategorik değişkenler ise sıklık, yüzdelik değerlerle ifade edilmiştir. Analizlerde p<0.05 değeri anlamlılık sınırı olarak belirlenmiştir. Bulgular:177 hasta ile yapılan görüşmelerde; 97’si (%54,8) erkek, 80’i (%45,2) kadındır. Hastaların yaş ortalaması 39’dur ve cinsiyetler arasında anlamlı farklılık görülmemektedir. Hastaların 83’ü (%46,9) hiç sigara içmediğini, 26’sı (%14,7) daha önce sigara içmiş ancak bıraktığını, 66’sı (%37,3) aktif olarak sigara kullandığını ve 2 hasta ise pasif içici konumda olduğunu ifade etmiştir. Hastalarda sigaraya başlama yaşı ortalama 18’dir ve cinsiyetler arasında anlamlı bir fark bulunmamaktadır (p>0.05). Kadınlar ve erkekler arasında bağımlılık derecesini gösteren nikotin bağımlılık puanları arasında anlamlı bir fark yoktur (p>0.05). Sigara kullanan 66 hastanın %25’i hafif derecede nikotin bağımlısı, %36,4’ü orta derecede nikotin bağımlısı, %34,8’i şiddetli nikotin bağımlısı ve %3’ü çok şiddetli nikotin bağımlısıdır. Cinsiyetle sigara içme durumu arasında anlamlı bir ilişki tespit edilmiştir, erkeklerin sigara içme durumunun kadınlara göre daha sık olduğu bulunmuştur (p<0,05). Günlük sigara kullanımı ile sigaraya başlama yaşı arasında pozitif bir korelasyon tespit edilmiştir. Günlük sigara kullanım miktarı ile cinsiyet arasında anlamlı bir ilişki yoktur (p>0.05). Sigara kullananların %72’si sigarayı bırakmayı düşünürken, %28’i bırakmayı düşünmediğini ifade etmiştir. Sonuç:Hastaların sigara içme durumlarının incelendiği bu çalışmada bağımlılık düzeyi ile cinsiyet arasında anlamlı bir fark bulunmamıştır. Erkekler ile kadınlar arasında sigara içme yoğunluğuna bakıldığında, erkekler arasında sigara içme durumu daha sık karşılaşılan bir durumdur. Erkeklerin %60’ı sigara kullanırken kadınlarda bu oran %26’dır. Sigara içenlerin büyük çoğunluğu bırakmak istediğini ifade etmiştir.
Technique of Breast Reconstruction with Expander Implants after Mastectomy
Authors: Krämer S , M Friedrich , C Kraft
Published: December 2018

The reconstruction of the female breast after mastectomy is an integral part of the surgical treatment of breast cancer nowadays. If it is necessary for oncologic reasons and if there are contraindications for breast conserving therapy, methods of breast reconstruction can contribute significantly to the restoration of physical integrity, including an improvement of life quality for the affected women. Besides an improvement or restoration of the physical image and of the self-esteem, breast reconstruction leads to a processing of an oncologically necessary mastectomy from a psychooncological and rehabilitative point of view. Alloplastic methods of breast reconstruction are the most common methods of reconstructing the female breast after mastectomy. In order to obtain optimal results from reconstruction, the use of textured, anatomically shaped expander-implant systems are recommended. After modified radical mastectomy a combined expander implant reconstruction can be indicated to reconstruct a smaller, non-ptotic breast after preforming stretching of the skin. This combined expander-implant reconstruction can be performed primarily during mastectomy as well as secondarily. If adjuvant therapy is necessary, especially in the case of radiation therapy, an implant or expander-implant reconstruction is relatively contraindicated because of an insufficiently high rate of complication. The patients need to be informed about the very often necessity of adapting mastopexy or reduction mastopexy of the contralateral breast and about possible autologous methods of reconstruction. In our opinion, adjuvant radiation therapy is a contraindication for alloplastic reconstruction because of an inacceptable complication rate, especially if compared to autologous reconstruction. Therefore, primary alloplastic reconstruction should be indicated very critically. When planning alloplastic or, of course, autologous breast reconstruction the overall oncological situation of the patient needs to be considered. To avoid prognostic or aesthetic disadvantages, the differential indication for the methods of breast reconstruction should ideally take place in specialized breast centres with experience in all methods of reconstruction.
Reflexões sobre o imperativo do gozo e a mercadorização da cultura
Authors: Gaião Brunno Fernandes da Silva , Leão André Luiz Maranhão de Souza
Published: December 2018

Partindo do pensamento žižekiano e tendo em mente o contexto da sociedade pós-industrial contemporânea, este artigo tem por objetivo discutir a relação entre a ideologia do imperativo do gozo vigente e o crescente processo de mercadorização da cultura em nossa época. Abordamos o caso particular do Carnaval do Recife como recurso ilustrativo para a condução de nossa reflexão. A instrumentalização da cultura como um recurso a ser aplicado para alcançar o crescimento econômico e sociopolítico estabelece os parâmetros de como as festas populares devem ser realizadas e fruídas. As festas são concebidas, planejadas, e preparadas dentro do horizonte da experiência de consumo, podendo ser consideradas objetos de desejo do sujeito-consumidor. A dimensão histórico-cultural é relegada a segundo plano na realização dos eventos. Por meio desta economia libidinal o capitalismo avança na transformação dos elementos da vida social em mercadorias/objetos de desejo, perpetuando a lógica de mercado capitalista.
Avaliação de desempenho por funções de governo através do método PROMETHEE II
Authors: Bezerra Victor Vidal de Negreiros , De Carvalho José Ribamar Marques
Published: December 2018

A avaliação de desempenho tem se apresentado como uma importante ferramenta para o desenvolvimento e melhoria da gestão pública no contexto municipal. Nesse sentido, o presente estudo busca cooperar no desenvolvimento e aprimoramento de avaliações de desempenho municipal através das técnicas multicritério de apoio à decisão. Tomando como base os indicadores de gasto per capita nas 28 funções de governo, este estudo objetiva verificar a performance dos municípios pertencentes às microrregiões paraibanas de Campina Grande e Esperança no que concerne aos gastos por funções de governo. Testando o método multicritério PROMETHEE II, foi possível identificar a aplicabilidade desse tipo de metodologia ao contexto da avaliação de desempenho de municípios. Esperança e Boa Vista foram os que mais se destacaram no ranking de performance, ao passo que os municípios de Massaranduba e Fagundes foram os que ocuparam as duas últimas posições nos anos de 2014 e 2015. Entende-se que essa avaliação comparativa é útil para destacar quais são os municípios que têm se sobressaído na gestão dos recursos públicos. Além disso, esse tipo de análise permite aos gestores estaduais, gestores federais e órgãos de controle identificar quais são os municípios que necessitam de maior acompanhamento e aporte de recursos com vistas a atender aos anseios da população local.
THE IMPORTANCE OF HYALURONIC ACID IN OPTIMIZATION OF THE RESULTS OF ORGANOS-CONSERVING OPERATIONS OF TRAUMATIC DAMAGE OF TESTICLES AND RESTORATION OF THEIR FUNCTIONS
Authors: Yuldashev S. M , Pavlov V. N , Yuldashev M. T , Bulygin L. G
Published: December 2018

One of the many causes of male infertility are traumatic damages of the scrotum organs, which in 80 % of cases are accompanied by rupture of the testicle and epididymis. With traumatic tearing of the testicles, the optimal method is an organ-preserving operation. For reliable recovery of the spermatogenesis process, an effective method is the implantation of a 30 % solution of hyaluronic acid, which helps protect the hematotestick barrier and restore spermatogenesis.
EEFFECTIVE CRITERIA OF EXPONENTIAL STABILITY OF AUTONOMOUS DIFFERENCE EQUATIONS
Authors: Kandakov Aleksandr Andreyevich , Chudinov Kirill Mikhaylovich
Published: December 2018

We obtain stability criteria for several classes of linear autonomous difference equations. The criteria are expressed in explisit analytic form, as well as in the form of belonging values of a vector function of the equation parameters to a domain in three-dimensional space.
NECESSARY OPTIMALITY CONDITIONS FOR OPTIMAL CONTROL PROBLEM WITH SECOND ORDER EQUATION
Authors: Kotyukov Alexandr Mikhailovich , Kotyukov Mikhail Mikhailovich
Published: December 2018

An optimal control problem with second order equation is considered. For this problem Pontryagin maximum principle is obtained. Also non-triviality condition is proved.
STABILITY OF ONE-PARAMETER SYSTEMS OF LINEAR AUTONOMOUS DIFFERENTIAL EQUATIONS WITH BOUNDED DELAY
Authors: Mulyukov Mikhail Vadimovich
Published: December 2018

We consider a system of linear autonomous differential equations with bounded delay in the case when its characteristic function depends linearly on one scalar parameter. The application of the D-subdivision method to the problem of constructing the stability region for this equation was developed.
ON THE CONVERGENCE AND RATE OF THE CONVERGENCE OF A PROJECTION-DIFFERENCE METHOD FOR APPROXIMATE SOLVING A PARABOLIC EQUATION WITH WEIGHT INTEGRAL CONDITION
Authors: Petrova Anastasiya Alexandrovna
Published: December 2018

In the Hilbert space the abstract linear parabolic equation with nonlocal weight integral condition for the solution is resolved approximately by projectiondifference method using time-implicit Euler’s method. Approximation of the problem by spatial variables is oriented on the finite element method. Errors estimations of approximate solutions, convergence of approximate solution to exact one and orders of rate of convergence are established.
ON THE NUMERICAL METHOD OF CONSTRUCTION OF UNSTABLE SOLUTIONS OF DYNAMICAL SYSTEMS WITH QUADRATIC NONLINEARITIES
Authors: Pchelintsev Alexander Nikolaevich
Published: December 2018

In this paper, the author considers the modification of the method of power series for the numerical construction of unstable solutions of systems of ordinary differential equations of chaotic type with quadratic nonlinearities in general form. A region of convergence of series is found and an algorithm for constructing approximate solutions is proposed.
ON THE STABILITY OF SOLUTIONS OF NONLINEAR SYSTEMS WITH IMPULSE STRUCTURE
Authors: Zhelonkina Natalia Igorevna , Sesekin Alexander Nikolaevich
Published: December 2018

In this paper we review the results of the authors related to the study of the stability property of solutions for nonlinear systems of differential equations, on the right-hand side of which there are terms containing products of discontinuous functions and distributions. The solutions of such systems are formalized by the closure of the set of smooth solutions in the space of functions of bounded variation. For such systems, sufficient conditions are obtained for the asymptotic stability of unperturbed solutions.
APPROXIMATION OF HYPERBOLIC DIFFERENTIAL INCLUSIONS OF FRACTIONAL ORDER WITH IMPULSES
Authors: Skomorokhov Victor Victorovich
Published: December 2018

In this paper there are considered hyperbolic differential inclusions of fractional order with impulses. Here we represent the concept of approximate solution (δ-solution) for a hyperbolic differential inclusion of fractional order with impulses. The asymptotic properties of solutions sets to approximating differential inclusions of fractional order with external disturbance are derived.
MAXIMAL LINKED SYSTEMS AND ULTRAFILTERS OF WIDELY UNDERSTOOD MEASURABLE SPACES
Authors: Chentsov Aleksandr Georgievich
Published: December 2018

Two types of set families (ultrafilters or maximal filters and maximal linked systems) for widely understood measurable space are considered. The resulting sets of ultrafilters and maximal linked systems are equipped with the pair of comparable topologies (within the meaning of «Wallman» and «Stone»). As a result, two bitopological spaces are realized; one of them turns out a subspace of another. More precisely, ultrafilters are maximal linked systems and the totality of the latter forms a cumulative bitopological space. With employment of topological constructions some characteristic properties of ultrafilters and (in smaller power) maximal linked systems are obtained (the question is necessary and sufficient conditions of maximality of filters and linked systems).
A sociedade civil organizada e o rompimento da barragem de fundão, Mariana (MG): porque é preciso difundir a geoética
Authors: Castro Paulo de Tarso A. , Ruchkys Úrsula , Manini Rafael Tertolino
Published: December 2018

A geoética é uma área emergente das geociências e a aplicação de seus princípios se mostra cada vez mais necessária. Esse arti-go tem como principal objetivo analisar o comportamento da sociedade civil organizada frente as causas e consequências do rompimento da Barragem de Fundão, Mariana (MG) considerada a maior catástrofe do país. Para tanto apresenta uma relação entre geoética e mineração ao analisar a reação frente vazamento de rejeitos da barragem por parte dos organismos de estado, das ONGs, da comunidade científica geológica, das entidades profissionais em geologia e dos órgãos regulamentadores da profissão. As análises indicam a necessidade urgente de uma abordagem geoética em diferentes níveis e setores da comunidade geológica.
Distributed Edge Computing to Assist Ultra Low Latency VANET Applications
Authors: Vladyko Andrei , Khakimov Abdukodir , Muthanna Ammar , Ateya Abdelhamied A. , Koucheryavy Andrey
Published: December 2018

VANET networks are a class of peer-to-peer wireless networks that are used to organize communication between cars (V2V), cars and infrastructure (V2I) and between cars and other types of nodes (V2X). These networks are based on the DSRC, 802.11 standards and are mainly intended for organizing the exchange of various types of messages, mainly emergency ones, to prevent road accidents or alert when road accident occur, or control the priority of the driveway. Initially it was assumed that cars would only interact with each other, but later, with the advent of the concept of Internet of things (IoT). Researchers began to analyze connectivity with other devices, which in general will allow to combine various road users and other devices that can used in the creation of intelligent transport infrastructure in a single smart city management system. Infrastructure is necessary for the provision of services, monitoring and management of the VANET network. As infrastructure objects it is proposed to use stationary objects of Roadside unit (RSU). The aim of this paper is to analyze the use of mobile edge computing to decrease the load to the base station and latency between RSU clouds and provide a real experiment using software defined networking and mobile edge computing for RSU.