bluuebunny/crossref_metadata_2025 huggingface dataset:
The Correlation Between Preoperative Lower Extremity Deep Vein Thrombosis (DVT) and the Time from Injury to Surgery (TFITS)
Authors: Cong Yuxuan , Huang Hai , Zhang Bin-Fei , Deng Hongli , Lei Jinlai , Ke Chao , Han Shuang , Zhang Kun , Wang Pengfei
Published: July 2022

Objective

To investigate the correlation between preoperative DVT and the time from injury to surgery (TFITS), and provide a clinical reference for the prevention of preoperative DVT.

Patients and methods

We collected the clinical data of patients with lower extremities fractures between September 1, 2014, and May 31, 2019. Doppler ultrasonography was used to diagnose DVT. Patients were divided into the 0-2d group, 3-4d group, 5-7d group, and >7d group according to TFITS. The correlation between TFITS and preoperative DVT was assessed using logistic regression according to the adjusted model.

Result

A total of 2831 patients were included in the study. The mean（+/-SD） TFITS was 6.11 ± 3.76 (0 to 21 d). A total of 821 (29.0%) cases had preoperative DVT, with the incidence of DVT being 8.0% in the 0-2d group, 23.8% in the 3-4d group, 32.0% in the 5-7d group, and 36.2% in the >7d group, with statistically significant differences(P＜0.05) among all the groups. The incidence of preoperative DVT increased with prolonged preoperative time. In the fully adjusted model, TFITS was positively correlated with the incidence of preoperative DVT (OR: 1.093; 95% CI: 1.068-1.118; P = 0.000), and the strength of the association increased with increasing time.

Conclusion

TFITS was an independent risk factor on the incidence of preoperative DVT. After excluding the effect of other factors, each 1d increases in TFITS was correlated with a 9.3% increase in the risk of preoperative DVT. The TFITS should be decreased to reduce the risk of preoperative DVT.
A Prospective Study Evaluating Patterns of Responses to the Caprini Score to Prevent Venous Thromboembolism After Interventional Treatment for Varicose Veins
Authors: Grill Marcelo Halfen , Caffaro Roberto Augusto , Grill Thiago Alverez , Júnior Valter Castelli , Kikuchi Rodrigo , Ribeiro Camilla Moreira , da Silva Viviane Santana , Tafur Alfonso J. , Caprini Joseph A. , Ramacciotti Eduardo
Published: July 2022

Background

Venous thromboembolism (VTE) is a critical complication of varicose vein treatments. The Caprini Score (CS) is an established tool to assess patients’ VTE risks. One disadvantage is the number of questions required, some of them referring to a low incidence of disease, even lower in patients seeking an elective procedure. These elements take time and may result in filling errors if the CS is not filled out by a properly trained health professional.

Objective

To establish a response pattern in CS, with emphasis on questions that usually have a negative answer and propose a simpler adaptative digital version without changing the original structure of the tool.

Methods

two hundred and twenty-seven patients in the pre-surgical treatment of varicose veins were enrolled prospectively and submitted to the CS evaluation.

Results

The pattern of dichotomous responses could be divided arbitrarily into four subgroups considering the percentage of positive responses: none (11 items), less than 3% (13 items), between 3% and 20% (5 items), and more than 20% (8 items). Of the 12 CS questions related to illnesses that occurred in the last month, ten had had no responses, and 2 were less than 3%.

Conclusion

There is a pattern in the CS responses of patients with an indication of surgical treatment of varicose veins. Many of the CS questions are not helpful in this scenario and may result in filling errors performed by untrained providers. An adaptative version of the CS might benefit varicose veins surgery VTE risk stratification
Is Antifibrinolytic Therapy Effective for Preventing Hemorrhage in Patients with Hemophilia Undergoing Dental Extractions? A Systematic Review and Meta-Analysis
Authors: Ullah Kaleem , Mukhtar Humza , Khalid Ushna , Sarfraz Zouina , Sarfraz Azza
Published: July 2022

Objectives

This systematic review aims to analyze the systemic administration of antifibrinolytics (tranexamic acid and aminocaproic acid) to prevent postoperative bleeding in patients with hemophilia.

Methods

This systematic review was conducted adhering to PRISMA guidelines. Only randomized controlled trials that assessed human subjects of any age or gender with any severity of hemophilia undergoing dental extractions, and systemically administered antifibrinolytic therapy compared to placebo were included. Post-operative bleeding episodes and adverse events were presented. PubMed, Cochrane, Embase, CINAHL, Web of Science, and Scopus were searched through April 15, 2022. The risk ratio (RR) and odds ratio (OR) applying 95% confidence intervals (CI) were computed using RevMan 5.4.1 (Cochrane).

Results

Two randomized, placebo-controlled trials pooling in a total of 59 patients were pooled in this analysis. Among patients administered antifibrinolytic therapy, 84% reduced risk of post-operative bleeding was reported (RR = 0.16, 95% CI = 0.05–0.47, P = 0.0009). The chances of post-operative bleeding were reduced by 95% among the antifibrotics group (OR = 0.05, 95% CI = 0.01–0.22, P < 0.0001).

Conclusion

This review finds favorable outcomes for the routine use of antifibrinolytic therapy for dental extractions in hemophiliacs. Further trials are required to rationalize existing evidence.
Shooting and Holding Fire in Police Work: Insights From a Study Informed by the Binder and Scharf Model of Deadly Force Decision-Making
Authors: Pickering Jordan C. , Klinger David
Published: July 2022

How police officers exercise their unique power to use deadly force continues to be a topic of interest among academics and has recently become arguably the most visible public policy issue related to the criminal justice system in the United States. Academic interest in officers’ use of deadly force includes attention to how officers make the decision to discharge their firearms during encounters with citizens. Binder and Scharf posited that actions and decisions made by officers early in a high-risk police-citizen encounter can impact their decision to use deadly force at the conclusion of the encounter. This decision-making model, however, has been subject to very little empirical scrutiny in the decades since it was proposed (see Fridell & Binder; Scharf & Binder for notable exceptions). To bring their comprehensive framework back to the forefront and provide additional empirical assessment, the authors used the Binder and Scharf model as a framework to examine 82 officers’ decisions to shoot or hold fire in incidents that involved multiple officers who ultimately made different decisions regarding lethal force. Results from the qualitative analysis suggest that the presence and actions of other officers on scene can have a notable impact on officers’ decision-making during a high-risk police-citizen encounter. Furthermore, findings from this study extend the Binder-Scharf model by highlighting the role of conscious and unconscious decision-making and the impact of social roles on officers’ choices during an officer-involved shooting.
Impact of Tumor Location on Survival in Patients With Colorectal Cancer: A Retrospective Cohort Study Based on Taiwan’s Cancer Registry Database
Authors: Yu Shou-Chun , Liao Kuang-Ming , Chou Chia-Lin , Tian Yu-Feng , Wang Jhi-Joung , Ho Chung-Han , Shiue Yow-Ling
Published: July 2022

Background:

Colorectal cancer is one of the leading cancers worldwide. This study aimed to investigate the mortality differences between 2 primary tumor locations, the proximal/distal colon and rectosigmoid junction (RSJ)/rectum, after adjusting for comorbidities.

Methods:

The Taiwan Cancer Registry linked with Taiwan’s National Health Insurance Research Database was used to estimate the 5-year mortality rate among patients with colorectal cancer. A total of 73 769 individuals were enrolled in the study, which included 44 234 patients with proximal and distal colon cancers and 29 535 patients with RSJ and rectal cancers. Potential mortality risk was calculated using Cox regression analysis.

Results:

The mortality rates due to the location of the cancer in the proximal/distal colon and RSJ/rectum were 45.27% and 42.20%, respectively. After adjustment for age, sex, comorbidities, and clinical stages, the proximal/distal colon had a 1.03-fold higher 5-year overall mortality rate than RSJ/rectal cancer (95% confidence interval = 1.00–1.05). Proximal and distal colon cancers had a worse prognosis and survival than RSJ and rectal colon cancers in women and older patients (⩾70 years). Comorbidities had different effects on mortality in the proximal/distal colon and RSJ/rectum.

Conclusions:

Tumor location is associated with the prognosis of patients with colorectal cancer. It is important to treat patients beyond their cancer treatment, and to manage their comorbidities.
Gender-age gaps in Euroscepticism and vote choice at the United Kingdom’s 2016 referendum on EU membership
Authors: Fowler Ceri
Published: July 2022

The result of the Brexit referendum and its effect on subsequent UK elections have attracted a large amount of media and scholarly interest, but there has been minimal research into gender and voting behaviour at the referendum. Similarly, gendered differences in Euroscepticism have had little attention. This article seeks to understand how attitudes towards the European Union vary by age and gender and whether such gender-age gaps are associated with gender differences in attributes known to predict European Union attitudes and support for Leave/Remain. The article finds a gender gap in Euroscepticism in under-45s and in Brexit vote choice in under-25s. It demonstrates that socioeconomic and value differences by gender are associated with the gender gap in younger age groups, but not older. As such differences seem likely to persist, this article suggests that gender divides will continue to have electoral and democratic consequences in the United Kingdom and across Europe.
First Case of Nellix Stent Rupture in a Huge Symptomatic Abdominal Aortic Aneurysm Who Underwent Endovascular Aneurysm Sealing 7 Years Before
Authors: Ferrero Emanuele , Quaglino Simone , Berardi Giuseppe , Manzo Paola , Ferri Michelangelo , Gaggiano Andrea
Published: July 2022

Purpose:

Despite encouraging early results, mid- and long-term follow-up of endovascular aneurysm sealing (EVAS) has shown increased rates of failure mainly associated with endoleak detection and progressive bag separation with aneurysm reperfusion.

Case Report:

We present the first case of a Nellix endograft stent fracture detected in a 91-year-old male patient, presenting with widespread abdominal pain, 7 years after elective treatment of an abdominal aortic aneurysm by EVAS. Considering the sudden and unexpected nature of the event, an in-depth analysis of the possible causes of this structural failure has been performed.

Conclusion:

Material fatigue could be another significant cause of late EVAS failure and should be carefully assessed in addition to endoleak detection during follow-up.

Clinical Impact

The case presented in this article further underlines the importance of a strict long term follow-up protocol in every patients who underwent EVAS.
Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer
Authors: Jotic Ana , Milovanovic Jovica , Savic-Vujovic Katarina , Radin Zorana , Medic Branislava , Folic Miljan , Pavlovic Bojan , Vujovic Aleksandar , Dundjerovic Dusko
Published: July 2022

Objective

The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer.

Material and Methods

A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples.

Results

Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4+ and CD8+ were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values.

Conclusion

Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma.
Dynamic modeling of a non-ideal gyroscopic rotor system with nonlinear damping and nonlinear rigidity of an elastic support
Authors: Iskakov Zharilkassin , Jamalov Nutpulla , Bissembayeb Kuatbay , Kamal Aziz
Published: July 2022

The article considers the effect of joint linear and nonlinear cubic damping on dynamics of a gyroscopic rigid rotor interacting with an electric motor with a rectilinear characteristic, taking into account the nonlinear rigidity of the support material. The method of regulating the control parameter (voltage on the motor), the amplitude of vibration, and the angular velocity of the shaft in the frequency equation, depending on the value of the coefficient of nonlinear cubic damping of the support, offers the most effective options for controlling resonant oscillations of large amplitudes. It is shown that the greater the value of the coefficient of nonlinear cubic damping, the easier it is to control these oscillations. Moreover, it is proved that the Sommerfeld effect (of the first kind) can also be weakened and eliminate with the help of joint linear and nonlinear damping. To do this, in the case of a rigid characteristic of the nonlinear elasticity of the support material, in a rotor system with a nonideal energy source to eliminate the bistability region, that is, jumping effects, more nonlinear damping of support or energy from a nonideal energy source will be required than in the case of an ideal rotor system.
The lateral collateral ligament complex of the elbow in a Thai population: an anatomical study of 56 cadaveric specimens
Authors: Saengsirinavin Pamok , Ratanalekha Rosarin , Piempuk Noppadol , Sriratanavudhi Chaivat , Jongthanakamol Thanawan , Jaroenporn Woraphon
Published: July 2022

The purpose of this study was to investigate the anatomical features of the lateral collateral complex (LCC) of the elbow in a Thai population. We dissected 56 cadaveric elbows and described the LCC three-dimensionally in sagittal and coronal planes. We found that the characteristics differed from previous reports in other ethnic populations. In the sagittal plane, the centre of the origin of the LCC was located 3 mm anteriorly and 4 mm inferiorly to the apex of the lateral humerus epicondyle, and in the coronal plane it was 4 mm deep. The vertical distance between the origin of the lateral ulnar collateral ligament (LUCL) and the lateral epicondyle and the distance from the LUCL insertion to the border of the ulnar bone differed significantly between sexes. These data may be useful for surgeons during reconstruction of injures to the LCC of the elbow.

Level of evidence: V
Measuring the bat-ball impact location from bat acceleration
Authors: Lyu Bin , Smith Lloyd
Published: July 2022

This study describes a novel method to identify the bat-ball impact location from accelerations measured at the bat knob. The magnitude of mode 1 and mode 2 accelerations were normalized by the swing speed and found as a function of the impact location. The impact location was identified by minimizing the error of normalized acceleration from impacts of batters swinging at different speeds. Impact locations from the accelerations were then compared with locations measured by high-speed video. Good agreement was found for bats with an asymmetric acceleration signature.
Bilateral Achilles Tendon Ruptures in the NFL
Authors: Chopra Aman , Parekh Aarav S. , Ramanathan Deepak , Parekh Selene G.
Published: July 2022

Background: Achilles tendon ruptures (ATR) can have devastating results for athletes in the National Football League (NFL). While many studies have examined the effects of an ipsilateral ATR, there are no reports on the impact of bilateral ATRs on NFL athlete performance. Methods: Publicly available online injury data for NFL athletes who sustained bilateral ATRs between the start of the 2007 season and the start of the 2021 season were queried using online news and sports analysis web sources. Results: After applying inclusion and exclusion criteria, 5 NFL athletes were identified. The findings demonstrated a significant difference in age at the time of each rupture (27.8 vs 30.4 years, P < .01) along with a decreasing trend in the number of Pro Bowl nominations following successive ATRs ( P = .027). There were no differences reported for the duration and number of games missed during either rehabilitation period following an ATR. Upon analyzing defensive NFL athletes, forced fumbles was the only performance metric that significantly changed across successive ATRs. Conclusion: Overall, bilateral ATRs can adversely impact an NFL player’s performance and further research should be performed to continue analyzing the effects of bilateral ATRs on these athletes.

Level of Evidence: 4
Spilling tea at the water cooler: A meta-analysis of the literature on workplace gossip
Authors: Wax Amy , Rodriguez Wiston A. , Asencio Raquel
Published: July 2022

This paper presents a meta-analysis on workplace gossip as a predictor of individual, relational, and organizational outcomes. Our systematic review yielded 52 independent studies ( n = 14,143). Results suggested that negative workplace gossip has a more deleterious association with workplace outcomes than positive gossip. Furthermore, findings indicated that negative gossip has a disproportionately negative association with attitudinal/affective outcomes and coworker relationships for targets of gossip. Unexpectedly, results also suggested that senders and recipients of negative gossip may also experience highly deleterious outcomes; in fact, the relations between negative gossip and well-being, engagement/performance, supervisor relationships, and organizational outcomes were more negative for gossip participants than targets, although the direction of causality for these relations has yet to be conclusively determined. Overall, our results suggest that organizations and managers should take seriously the threat of negative gossip to the health of the organization at large, while simultaneously leveraging the potential benefits of positive gossip.

This paper presents a meta-analysis on the topic of workplace gossip as a predictor of work-relevant outcomes. Results—which were based on 52 independent studies that, in total, employed 14,143 independent research participants—suggested that negative workplace gossip has a worse impact on individual, relational, and organizational outcomes than positive gossip does. Furthermore, our findings indicated that targets of negative gossip experience the worst outcomes in terms of attitudes/affect and coworker relationships, when compared with the outcomes of individuals who exchanged the gossip. Unexpectedly, patterns of results also suggested that individuals who exchange negative gossip at work may also experience highly deleterious outcomes, although the direction of causality for these relations has yet to be conclusively determined. Overall, our results suggest that organizations and managers should take seriously the threat of negative gossip to the health of the organization at large, and may also be able to leverage the potentially beneficial effects of positive gossip. We conclude with a discussion of the implications of our results.
The Roles of Worry, Social Media Information Overload, and Social Media Fatigue in Hindering Health Fact-Checking
Authors: Jiang Shaohai
Published: July 2022

Health misinformation has become a salient issue on social media. To lower the risk of health misinformation, fact-checking matters. However, most existing studies investigated fact-checking from the journalism angle, while little is known about how information-seekers’ social media use affects their fact-checking behaviors. Also, it remains unclear how individuals’ health worry is associated with health fact-checking. Based on the O-S-O-R model, this study explored the underlying mechanism through which health worry and social media might hinder users’ fact-checking. Specifically, with a two-wave panel survey conducted in China during the COVID-19 pandemic, this study showed that individuals’ worry about COVID-19 increased social media information overload, which resulted in social media fatigue that could reduce health fact-checking. Also, the direct relationship between worry and fact-checking was not significant, but was completely mediated by social media information overload and social media fatigue. The findings demonstrate the negative roles of worry and social media in inhibiting users’ fact-checking behaviors. Important theoretical and practical implications for promoting effective fact-checking are discussed.
HIV Related Stigma among Healthcare Providers: Opportunities for Education and Training
Authors: Spence Amanda Blair , Wang Cuiwei , Michel Katherine , Ocampo Joanne Michelle , Kharfen Michael , Merenstein Daniel , Goparaju Lakshmi , Kassaye Seble
Published: July 2022

Background: HIV-stigma can influence engagement in care and viral suppression rates among persons living with HIV (PLWH). Understanding HIV-provider level stigma and its associated factors may aid in development of interventions to improve engagement in care. Methods: We assessed HIV-related stigma, provider knowledge, and practices and beliefs among healthcare providers using an online survey tool. Generalized linear modeling was used to determine factors associated with HIV-stigma score. Results: Among 436 participants, the mean age was 42.3 (SD 12.3), 70% female, 62% white, 65% physicians, and 44% worked at an academic center. The mean HIV Health Care Provider Stigma Scale (HPASS) score was 150.5 (SD 18.9, total = 180 [higher score = less stigma]) with factor subscale scores of 67.1 (SD 8.2, total = 78) prejudice, 51.3 (SD 9.7, total = 66) stereotyping, and 32.1 (SD 5, total = 36) discrimination. Female sex and comfort with talking about sex and drug use had 4.97 (95% CI 0.61, 9.32) and 1.99 (95% CI 0.88, 3.10) estimated higher HPASS scores. Disagreement/strong disagreement versus strong agreement with the statement that PLWH should be allowed to have babies and feeling responsible for talking about HIV prevention associated with −17.05 (95% CI −25.96, −8.15) and −2.16 (95% CI −3.43, −0.88) estimated lower HPASS scores. Conclusions: The modifiable factors we identified as associated with higher HIV related stigma may provide opportunities for education that may ameliorate these negative associations.
Sexual Expression, Policies, and Practices in Skilled Nursing Settings Serving Older Adults: An Updated Assessment in the State of Kansas
Authors: Jen Sarah , Jeong Mijin , Lafountain Olivia , Doll Gayle , Cornelison Laci
Published: July 2022

Doll assessed sexual expressions, policies, and practices in Skilled Nursing Facilities (SNFs) in the state of Kansas. This study provided an updated and expanded assessment. A mixed-methods survey was distributed to administrators of all SNFs in the state of Kansas. Among 60 administrations, 84% reported any sexual expression among residents in their community within the past year and 55% reported expressions involving an individual with cognitive impairment. In response to sexual expressions, 70% of administrators believe staff would treat residents with dignity and respect and about 40% anticipated staff discomfort. About 40% of administrators reported having a policy related to sexual expression. Attitudes and responses of staff and administrators appear to be shifting in a sex-positive direction. While policies related to sexuality are more common than a decade ago, there is room for additional uptake, standardization, and infusion of person-centered language and practices.
Emotional subjectivities and the trajectory of a Peruvian mining conflict
Authors: Balderson Ursula
Published: July 2022

The trajectory of socio-environmental conflicts remains difficult to predict. In the case study explored in this article, attention to the emergence of emotional subjectivities helps us better understand the timing of the conflict and the style of contestation at the site. The data are drawn from interviews and observations of the ‘dialogue table’ meetings that took place between representatives from the BarrickGold run Pierina mine in Ancash, a highland area in Peru, and the nearby village of Mataquita to try and resolve a conflict over access to water. The paper identifies three ways that the emotional climate at the site influenced the conflict trajectory. Firstly, it was heightened fear for future water availability and increased feelings of hope that the mining company could be held to account for the hydrosphere disruption that triggered the conflict. Secondly, the Mataquitans tried to elicit feelings of compassion in mining company representatives whilst the company acted to repress them, fearing that they could endanger profit-making at the site. Finally, the inconsistent behaviour of the mining company and their ad hoc Corporate Social Responsibility allocations produced a moral-emotional critique of mine behaviour and a climate of distrust within and between villages. The emotions produced by interactions between actors reduced the likelihood of a more coordinated response to the problems at the site, conveniently serving the agenda of the mine.
Reformulating the developmental state theory to explain Chinese spatial planning
Authors: Sonn Jung Won , Choi Mack Joong
Published: July 2022

Developmental state literature almost completely neglects the fact that one of the unique features of the developmental state is its capacity to reorganize its territory, and the literature on the Chinese developmental state repeats the same oversight. Against this backdrop, this study attempts to retheorize China’s spatial planning from a developmental state perspective. In light of the theoretical discussion in this study, we argue that the developmentalist spatial planning has five main characteristics of the developmentalist spatial planning: (1) The state sees its territory as a means of production, not as a living environment. (2) Industrial location policies were market-conforming. (3) The spatial planning was controlled or strongly influenced by the elite economic agency that formulates industrial policies and guides the market. (4) The bureaucracy is more or less insulated from local growth coalitions. (5) Spatial planning creates rather than responds to economic changes. These five characteristics are apparent in China’s spatial planning as much as in South Korea’s.
Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma
Authors: Gooding Sarah , Ansari-Pour Naser , Kazeroun Mohammad , Karagoz Kubra , Polonskaia Ann , Salazar Mirian , Fitzsimons Evie , Sirinukunwattana Korsuk , Chavda Selina , Ortiz Estevez Maria , Towfic Fadi , Flynt Erin , Pierceall William , Royston Daniel , Yong Kwee , Ramasamy Karthik , Vyas Paresh , Thakurta Anjan
Published: July 2022

The acquisition of a multidrug refractory state is a major cause of mortality in myeloma. Myeloma drugs that target the cereblon (CRBN) protein include widely used immunomodulatory drugs (IMiDs), and newer CRBN E3 ligase modulator drugs (CELMoDs), in clinical trials. CRBN genetic disruption causes resistance and poor outcomes with IMiDs. Here, we investigate alternative genomic associations of IMiD resistance, using large whole-genome sequencing patient datasets (n = 522 cases) at newly diagnosed, lenalidomide (LEN)-refractory and lenalidomide-then-pomalidomide (LEN-then-POM)-refractory timepoints. Selecting gene targets reproducibly identified by published CRISPR/shRNA IMiD resistance screens, we found little evidence of genetic disruption by mutation associated with IMiD resistance. However, we identified a chromosome region, 2q37, containing COP9 signalosome members COPS7B and COPS8, copy loss of which significantly enriches between newly diagnosed (incidence 5.5%), LEN-refractory (10.0%), and LEN-then-POM-refractory states (16.4%), and may adversely affect outcomes when clonal fraction is high. In a separate dataset (50 patients) with sequential samples taken throughout treatment, we identified acquisition of 2q37 loss in 16% cases with IMiD exposure, but none in cases without IMiD exposure. The COP9 signalosome is essential for maintenance of the CUL4-DDB1-CRBN E3 ubiquitin ligase. This region may represent a novel marker of IMiD resistance with clinical utility.
qRAT: an R-based stand-alone application for relative expression analysis of RT-qPCR data
Authors: Flatschacher Daniel , Speckbacher Verena , Zeilinger Susanne
Published: July 2022

Background

Reverse transcription quantitative real-time PCR (RT-qPCR) is a well-established method for analysing gene expression. Most RT-qPCR experiments in the field of microbiology aim for the detection of transcriptional changes by relative quantification, which means the comparison of the expression level of a specific gene between different samples by the application of a calibration condition and internal reference genes. Due to the numerous data processing procedures and factors that can influence the final result, relative expression analysis and interpretation of RT-qPCR data are still not trivial and often necessitate the use of multiple separate software packages capable of performing specific functions.

Results

Here we present qRAT, a stand-alone desktop application based on R that automatically processes raw output data from any qPCR machine using well-established and state-of-the-art statistical and graphical techniques. The ability of qRAT to analyse RT-qPCR data was evaluated using two example datasets generated in our laboratory. The tool successfully completed the procedure in both cases, returning the expected results. The current implementation includes functionalities for parsing, filtering, normalizing and visualisation of relative RT-qPCR data, like the determination of the relative quantity and the fold change of differentially expressed genes as well as the correction of inter-plate variation for multiple-plate experiments.

Conclusion

qRAT provides a comprehensive, straightforward, and easy-to-use solution for the relative quantification of RT-qPCR data that requires no programming knowledge or additional software installation. All application features are available for free and without requiring a login or registration.
Risk factors and predictive nomograms for early death of patients with advanced hepatocellular carcinoma: a large retrospective study based on the SEER database
Authors: Zhang Haidong , Du Xuanlong , Dong Hui , Xu Wenjing , Zhou Pengcheng , Liu Shiwei , Qing Xin , Zhang Yu , Yang Meng , Zhang Yewei
Published: July 2022

Background

Hepatocellular carcinoma (HCC) is a kind of tumor with high invasiveness, and patients with advanced HCC have a higher risk of early death. The aim of the present study was to identify the risk factors of early death in patients with advanced HCC and establish predictive nomograms.

Methods

Death that occurred within 3 months of initial diagnosis is defined as early death. Patients diagnosed with stage IV HCC between 2010 and 2015 were collected from the Surveillance, Epidemiology, and End Results database for model establishment and verification. Univariable and multivariable logistic regression analyses were used to identify the risk factors. Predictive nomograms were constructed and an internal validation was performed. Decision curve analysis (DCA) was used to verify the true clinical application value of the models.

Results

Of 6603 patients (57% age > 60, 81% male, 70% white, 46% married), 21% and 79% had stage IVA and IVB, respectively. On the multivariable analyses, risk factors for early deaths in patients with stage IVA were age, tumor size, histological grade, alpha-fetoprotein (AFP), fibrosis score, tumor stage (T stage), surgery, radiotherapy, and chemotherapy, and that in stage IVB were age, histological grade, AFP, T stage, node stage (N stage), bone metastasis, lung metastasis, surgery, radiotherapy, and chemotherapy. The areas under the curves (AUCs) were 0.830 (95% CI 0.809–0.851) and 0.789 (95% CI 0.768–0.810) in stage IVA and IVB, respectively. Nomograms comprising risk factors with the concordance indexes (C-indexes) were 0.820 (95% CI 0.799–0.841) in stage IVA and 0.785 (95% CI 0.764–0.0.806) in stage IVB for internal validation (Bootstrapping, 1000re-samplings). The calibration plots of the nomograms show that the predicted early death was consistent with the actual value. The results of the DCA analysis show that the nomograms had a good clinical application.

Conclusion

The nomograms can be beneficial for clinicians in identifying the risk factors for early death of patients with advanced HCC and predicting the probability of early death, so as to allow for individualized treatment plans to be accurately selected.
Using comprehensive geriatric assessment for older adults undertaking a facility-based transition care program to evaluate functional outcomes: a feasibility study
Authors: Wong Ying Git , Hang Jo-Aine , Francis-Coad Jacqueline , Hill Anne-Marie
Published: July 2022

Background

The study aimed to evaluate the feasibility of using a comprehensive geriatric assessment (CGA) in a residential transition care setting to measure older adults’ functional outcomes.

Methods

A convenience sample of older adults (n = 10) and staff (n = 4) was recruited. The feasibility of using assessment tools that comprise a CGA to comprehensively measure function in physical, cognitive, social and emotional domains was evaluated pre- and post-rehabilitation.

Results

10 older adults (mean ± SD age = 78.9 ± 9.1, n = 6 male) completed a CGA performed using assessments across physical, cognitive, social and emotional domains. The CGA took 55.9 ± 7.3 min to complete. Staff found CGA using the selected assessment tools to be acceptable and suitable for the transition care population. Older adults found the procedure to be timely and 60% found the assessments easy to comprehend. Participating in CGA also assisted older adults in understanding their present state of health. The older adults demonstrated improvements across all assessed domains including functional mobility (de Morton Mobility Index; baseline 41.5 ± 23.0, discharge 55.0 ± 24.0, p = 0.01) and quality of life (EQ-5D-5L; baseline 59.0 ± 21.7, discharge 78.0 ± 16.0, p < 0.01).

Conclusions

Incorporating CGA to evaluate functional outcomes in transition care using a suite of assessment tools was feasible and enabled a holistic assessment.
Midlateral medullary infarction presenting with isolated thermoanaesthesia: a case report
Authors: Hanada Keisuke , Yokoi Kayoko , Kashida Natsuko , Shimomura Ryota , Murata Daiki , Hirayama Kazumi
Published: July 2022

Background

A small lateral medullary lesion could produce isolated impairment of temperature sensation without concomitant impaired pain sensation. However, only one such case has ever been reported, and there are no reports on subjective symptoms and detailed somatosensory testing.

Case presentation

Herein, we report the case of a 53-year-old female patient presenting with impaired temperature sensation on the left half of her body, from the neck down, following a small infarction of the right midlateral medulla. The chronological changes in the patient's introspection regarding impairment of thermoception and the results of detailed somatosensory tests, including thermal sense, are shown in this report.

Conclusions

Thorough somatosensory tests, personal descriptions of symptoms, and electrophysiological quantification of similar cases are needed to improve our understanding of the neurological separation of the sensations of pain and temperature at the medullary level.
Perinatal mental health literacy: knowledge, attitudes, and help-seeking among perinatal women and the public – a systematic review
Authors: Daehn Daria , Rudolf Sophie , Pawils Silke , Renneberg Babette
Published: July 2022

Background

The perinatal period is a time of increased vulnerability to mental health problems, however, only a small proportion of women seek help. Poor mental health literacy (MHL) is a major barrier to seeking help for mental health problems. This study aimed to collect the existing evidence of MHL associated with perinatal mental health problems (PMHP) among perinatal women and the public. This review analysed which tools were used to assess perinatal MHL as well as the findings concerning individual components of perinatal MHL.

Methods

Four electronic databases (PubMed, PsycINFO, Web of Science, and CINAHL) were analysed from their inception until September 1, 2020. Not only quantitative studies reporting on components of MHL (knowledge, attitudes, and help-seeking), but also studies reporting overall levels of MHL relating to PMHP were taken into account. Two independent reviewers were involved in the screening and extraction process and data were analysed descriptively.

Results

Thirty-eight of the 13,676 retrieved articles satisfied the inclusion criteria. The majority of selected studies examined MHL related to PMHP in perinatal women (N = 28). The most frequently examined component of MHL in the selected data set was help-seeking. A lack of uniformity in assessing MHL components was found. The most common focus of these studies was postpartum depression. It was found that the ability to recognize PMHP and to identify relevant symptoms was lacking among both perinatal women and the public. Perinatal women had low intentions of seeking help for PMHP and preferred seeking help from informal sources while reporting a variety of structural and personal barriers to seeking help. Stigmatizing attitudes associated with PMHP were found among the public.

Conclusions

There is a need for educational campaigns and interventions to improve perinatal MHL in perinatal women and the public as a whole.
Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis
Authors: Ketavarapu Vijayasarathy , Ravikanth Vishnubhotla , Sasikala Mitnala , Rao G. V. , Devi Ch. Venkataramana , Sripadi Prabhakar , Bethu Murali Satyanarayana , Amanchy Ramars , Murthy H. V. V. , Pandol Stephen J. , Reddy D. Nageshwar
Published: July 2022

Background

Pathophysiology of transformation of inflammatory lesions in chronic pancreatitis (CP) to pancreatic ductal adenocarcinoma (PDAC) is not clear.

Methods

We conducted a systematic review, meta-analysis of circulating metabolites, integrated this data with transcriptome analysis of human pancreatic tissues and validated using immunohistochemistry. Our aim was to establish biomarker signatures for early malignant transformation in patients with underlying CP and identify therapeutic targets.

Results

Analysis of 19 studies revealed AUC of 0.86 (95% CI 0.81-0.91, P < 0.0001) for all the altered metabolites (n = 88). Among them, lipids showed higher differentiating efficacy between PDAC and CP; P-value (< 0.0001). Pathway enrichment analysis identified sphingomyelin metabolism (impact value-0.29, FDR of 0.45) and TCA cycle (impact value-0.18, FDR of 0.06) to be prominent pathways in differentiating PDAC from CP. Mapping circulating metabolites to corresponding genes revealed 517 altered genes. Integration of these genes with transcriptome data of CP and PDAC with a background of CP (PDAC-CP) identified three upregulated genes; PIGC, PPIB, PKM and three downregulated genes; AZGP1, EGLN1, GNMT. Comparison of CP to PDAC-CP and PDAC-CP to PDAC identified upregulation of SPHK1, a known oncogene.

Conclusions

Our analysis suggests plausible role for SPHK1 in development of pancreatic adenocarcinoma in long standing CP patients. SPHK1 could be further explored as diagnostic and potential therapeutic target.
Is RDW a clinically relevant prognostic factor for newly diagnosed multiple myeloma? A systematic review and meta-analysis
Authors: Chen Xiaomin , Liu Jiayue , Duan Jialin , Xiong Hao , Liu Yang , Zhang Xinwen , Huang Chunlan
Published: July 2022

Background

Multiple myeloma (MM) is an incurable plasma cell malignancy. Red cell distribution width (RDW) is a prognostic marker in various diseases, solid tumors, and hematologic neoplasms, but its prognostic significance in MM is controversial. In this study, we aimed to assess the relationship between RDW and the clinical prognosis of MM patients through a meta-analysis.

Methods

Relevant literature were retrieved from PubMed, Embase, and Web of Science databases according to PRISMA guideline. All relevant parameters were extracted and combined for statistical analysis. The effect size was presented as hazard ratio (HR)/odds ratio (OR) and 95% confidence interval (CI). HR/OR > 1 in MM patients with high RDW suggested a worse prognosis. Heterogeneity test evaluation was performed using Cochran's Q test and I2 statistics. A Pheterogeneity < 0.10 or I2 > 50% suggested significant heterogeneity. P < 0.05 was considered statistically significant. Statistical analysis was performed using Stata 12.0 software.

Results

8 articles involving 9 studies with 1165 patients were included in our meta-analysis. Our results suggested that elevated RDW is significantly associated with poor prognosis in MM (OS: HR = 1.91, 95%CI: 1.48–2.46; PFS: HR = 2.87, 95% CI: 2.02–4.07). A significant correlation was not found between RDW and International Staging System (ISS) staging (ISS III VS ISS I-II: OR:1.53; 95%CI:0.97–2.42).

Conclusion

Our results suggested that RDW is a robust predictor of newly diagnosed MM outcomes.
Feasibility and acceptability of a novel telepsychiatry-delivered precision prescribing intervention for anxiety and depression
Authors: O’Callaghan Erin , Sullivan Scott , Gupta Carina , Belanger Heather G. , Winsberg Mirène
Published: July 2022

Background

Major Depressive Disorder and Generalized Anxiety Disorder are pervasive and debilitating conditions, though treatment is often inaccessible and based on trial-and-error prescribing methods. The present observational study seeks to describe the use of a proprietary precision prescribing algorithm piloted during routine clinical practice as part of Brightside’s telepsychiatry services. The primary aim is to determine the feasibility and acceptability of implementing this intervention. Secondary aims include exploring remission and symptom improvement rates.

Methods

Participants were adult patients enrolled in Brightside who completed at least 12 weeks of treatment for depression and/or anxiety and received a prescription for at least one psychiatric medication. A prescription recommendation was made by Brightside’s algorithm at treatment onset and was utilized for clinical decision support. Participants received baseline screening surveys of the PHQ-9 and GAD-7, and at weeks 2,4,6,8,10 and 12. Intent-to-treat (ITT) sensitivity analyses were conducted. Feasibility of the implementation was measured by the platform’s ability to enroll and engage participants in timely psychiatric care, as well as offer high touch-point treatment options. Acceptability was measured by patient responses to a 5-star satisfaction rating.

Results

Brightside accessed and treated 6248 patients from October 2018 to April 2021, treating a majority of patients within 4-days of enrollment. The average plan cost was $115/month. 89% of participants utilized Brightside’s core medication plan at a cost of $95/month. 13.4% of patients in the study rated Brightside’s services as highly satisfactory, averaging a 4.6-star rating. Furthermore, 90% of 6248 patients experienced a MCID in PHQ-9 or GAD-7 score. Remission rates were 75% (final PHQ-9 or GAD-7 score < 10) for the study sample and 59% for the ITT sample. 69.3% of Brightside patients were treated with the medication initially prescribed at intake.

Conclusions

Results suggest that the present intervention may be feasible and acceptable within the assessed population. Exploratory analyses suggest that Brightside’s course of treatment, guided by precision recommendations, improved patients’ symptoms of anxiety and depression.
Comorbidity of adult ADHD and substance use disorder in a sample of inpatients bipolar disorder in Iran
Authors: Badrfam Rahim , Zandifar Atefeh , Barkhori Mehni Mahdi , Farid Malihe , Rahiminejad Fatemeh
Published: July 2022

Backgrounds

The study of the relationship between adult Attention deficit hyperactivity disorder (ADHD) and bipolar disorder has received more attention in recent years and there is limited information in this area. On the other hand, there is a significant comorbidity between ADHD and bipolar disorder with substance use disorder. In this study, we investigated the prevalence of comorbidity of adult ADHD and substance use disorder among a group of bipolar patients admitted to a psychiatric hospital.

Methods

One hundred fifty patients from a total of 200 consecutive patients who were referred to the emergency department of Roozbeh Psychiatric Hospital in Tehran, diagnosed with bipolar disorder based on the initial psychiatric interview and needed hospitalization, were evaluated again by an experienced faculty member psychiatrist by using a subsequent interview based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition(DSM-5).

They were evaluated using the Structured Clinical Interview for DSM-5 (SCID-5) questionnaire to confirm the diagnosis of bipolar disorder and the comorbidity of adult ADHD and substance use disorder.

Results

From 150 patients diagnosed with bipolar disorder, 106 patients (70.7%) had adult ADHD. 89 patients (59.3%) had substance use disorder and 58 patients (38.7%) had both of these comorbidities with bipolar disorder. Comorbidity of adult ADHD was associated with the earlier onset of the first mood episode in bipolar disorder (p value = 0.025). There was no statistically significant relationship between substance use disorder and age of onset of the first episode. (P value = 0.57).

Conclusions

Due to the limitations of studies on adult ADHD comorbidity with bipolar disorder, especially in hospital settings, as well as the increased risk of association with substance use disorder, further multicenter studies in this area with larger sample sizes can increase awareness in this regard.
Early (years) reactions: comparative analysis of early childhood policies and programs during the first wave of the COVID-19 pandemic
Authors: Kearon Joanne , Carsley Sarah , van den Heuvel Meta , Hopkins Jessica
Published: July 2022

Background

During the first wave of COVID-19 there was little evidence to guide appropriate child and family programs and policy supports.

Methods

We compared policies and programs implemented to support early child health and well-being during the first wave of COVID-19 in Australia, Canada, the Netherlands, Singapore, the UK, and the USA. Program and policy themes were focused on prenatal care, well-baby visits and immunization schedules, financial supports, domestic violence and housing, childcare supports, child protective services, and food security.

Results

Significant heterogeneity in implementation of OECD-recommended policy responses was found with all of the included countries implementing some of these policies, but no country implementing supports in all of the potential areas.

Conclusions

This analysis gives insight into initial government reactions to support children and families, and opportunities for governments to implement further supportive programs and policies during the current pandemic and future emergencies.