bluuebunny/crossref_metadata_2025 huggingface dataset:
Manhaj Penafsiran Hamka
Authors: Nabil Amir Ahmad
Published: April 2023

The paper discusses the underlying method and context of interpretation of legal verses as set forth by Hamka in his magnum opus, Tafsir al-Azhar. It looks into the historical background and dynamics of his interpretation of legal verses that bring forth significance breakthrough in the articulation of classical theoretical perspective of fiqh, maqasid (higher objective of Islamic law), maslahah (public good) and fundamental of syariah. The study is based on library research using qualitative and scientific approach. Relevant data were collected from primary and secondary sources and analyzed through descriptive, analytical and comparative technique. The finding shows that the Tafsir has bring forth significance breakthrough in legal interpretation that shed light on philosophical and contextual meaning of the ayah, projecting rational dan liberal understanding of the text, independent from classical interpretation and doctrine of traditional ruling and school of thought. It shed lights on universal dan dynamic religious spirit and reassertion and reconstruction of ijtihad and socio-legal reform, arguing for the significant local dynamics, norms and ethics of fiqh nusantara (Malay-Indonesian archipelago) which addresses contemporary needs of modern Indonesia’s complex multicultural and cosmopolite society. 
 
Kajian ini membahas metode penelitian hukum yang dilakukan oleh Hamka dalam Tafsir al-Qur'an karangannya, Tafsir al-Azhar. Kajian ini bertujuan untuk melihat alur dan konteks pemikiran Hamka dalam kajian hukum dan syariah terkait dengan aspek pembaharuan ideologi hukum, fikih, maqasid, pemahaman maslahah dan ushul syariah. Metodologi penelitian adalah kualitatif dari jenis penelitian kepustakaan. Bahan penelitian diperoleh dari sumber primer dan sekunder yang terkait dan dianalisis secara deskriptif, analitis dan komparatif. Hasil kajian menyimpulkan bahwa Hamka mempunyai kesederhanaan dan keluasan pandangan hukum yang tidak terikat oleh doktrin dan ideologi mazhab. Ini menunjukkan pandangan klasik dan universal yang mempertahankan nilai kebebasan dan ijtihad serta semangat hukum yang rasional dan kontekstual yang dipengaruhi oleh fikih nusantara dengan tujuan mendekatkan pemahaman hukum dengan nuansa kehidupan masyarakat dan konteks perkembangan Islam di Indonesia yang modern dan kosmopolit.
Budaya dan Tradisi Sebagai Titik Temu: Konstruksi Muslim Fundamental dalam Bingkai Multikulturalisme Lintas Iman di Desa Kasembon, Kabupaten Malang
Authors: Sutaman  , Abdul Hakim  , Samsuri
Published: April 2023

P ini bertujuan untuk mengetahui bagaimana konstruksi masyarakat Muslim fundamentalis dalam membina kerukunan beragama lintas Iman di Kecamatan Kasembon Malang. Selain itu, penelitian ini juga bertujuan untuk menjelaskan medan budaya apa saja yang dijadikan Muslim fundamentalis dalam membina kerukunan beragama lintas Iman di Kecamatan Kasembon Malang. Pada waktu yang bersamaan, penelitian ini juga bertujuan untuk menjelaskan bagaimana respons masyarakat Hindu dan Kristen Kecamatan Kasembon Malang dalam bina harmoni yang dikonstruksikan oleh masyarakat Muslim fundamentalis. Metode yang digunakan dalam penelitian ini adalah studi komunitas (community studies) dengan pendekatan Sosio-Antroplogis. Metode pengumpulan data dalam penelitian ini, berupa participant observation dan indepth interview.

Adapun hasil dari penelitian ini adalah, Pertama: Ekspresi fundamentalisme masyarakat Muslim dapat dilihat dari sikapnya yang tidak mau memberikan ucapan selamat Natal dan tahun baru kepada ummat Kristiani dan juga ucapan selamat Nyepi dan Ogoh-ogoh kepada ummat Hindu. Ekspresi ini dilatarbelakangi adanya kesadaran teologis bahwa mengucapkan selamat hari raya Natal dan Nyepi serta Ogoh-ogoh adalah bentuk penggadaian teologis yang tidak bisa ditawar-tawar. Pilihan sikap fudamentalisme masyarakat Muslim ini bertolak belakang dari persepsi pada umumnya yang menganggap mereka eksklusif dan tidak humanis. Kenyataan itu terpatahkan oleh character building yang dibangun masyarakat dalam menghargai perbedaan dan menjunjung tinggi nilai-nilai toleransi dan multikulturalisme.

Kedua; tradisi toleransi beragama di Kasembon Malang sudah berjalan sejak nenek moyang mereka. Toleransi antar umat beragama di tengah kehidupan yang multikultural di Kasembon Malang acapkali dipertemukan dengan beberapa tardisi-tradisi dan budaya yang sudah terbina sejak dahulu kala. Misalnya ketika bersih desa dan 17 Agustusan semua warga Kasembon Malang bersatu padu membersihkan desa dan bergotong-royong secara harmoni tanpa sekat.  Sementara para perempuan saling guyub menyediakan jajanan dan makanan untuk para bapak-bapak.

Ketiga; Respon masyarakat Kristen dan Hindu di Kasembon Malang awalnya tidak bisa menerima model formulasi multikulturalisme yang diterapkan oleh warga Muslim fundamentalis. Namun seiring dengan berjalannya waktu dan sikap-sikap kooperatif dalam membangun kualitas sosial, maka masyarakat Hindu dan Kristenpun akhirnya memahami bahwa pemahaman terhadap sikap kaum Muslim fundamental yang tidak mau mengucapkan Natal dan Nyepi adalah bagian dari kehidupan multikulturalisme yang tidak bisa dielakkan. Penerimaan sikap masyarakat Hindu dan Kristen tentunya bukan tanpa alasan. Pijakan teologis dalam kitab Wedha dan Alkitab adalah salah satu pijakan yang digunakan untuk membangun toleransi di tengah kehidupan multikulturalisme lintas iman.
NILAI-NILAI SUFISTIK ISLAM NUSANTARA DALAM TERCIPTANYA KERUKUNAN UMAT BERAGAMA
Authors: Wahyuningsih Endah , Mukari
Published: April 2023

Maraknya pertikaian, terorisme, radikalisme didunia seringkali dikaitkan dengan  agama terutama agama Islam. Hal ini berdampak pada seolah ada yang salah dengan agama  dan fungsi keberadaannya sebagai sarana yang mampu mendamaikan justru kebalikannya.  Kehadiran nilai-nilai dalam nalar sufi ternyata mampu menembus jurang pemisah hal inilah  yang menjadikannya sebagai role model untuk membangun peradaban dan perdamaian umat  manusia. 

Nilai-nilai sufi yang ada seperti sang pencipta/ Tuhan sebagai pusat kehidupan,  adanya keikhlasan dan kekhusu’an dalam relasi antar manusia dan relasi dengan Tuhan,  terdapat budi pekerti, nalar sufi dibangun atas spiritual bukan logika dan dikontruksi melalui  pemahaman agama yang inkusif dan toleran. 

Budaya riyaya unduh-unduh yang digagas oleh Jemaat Kristen Jawi Wetan  Mojowarno adalah salah satu contoh bahwa didalam agama Nasrani juga terdapat nilai-nilai  sufi dalam konteks agama Nasrani tetapi secara esensi sama, dan itu berlangsung sejak  dahulu sampai dengan saat ini. Hal ini menandakan bahwa nilai-nilai dalam nalar sufistik  layak dijadikan landasan dalam membangun peradaban manusia yang lebih baik.
JIHAD EKOLOGI MELAWAN EKSPLOITASI TAMBANG EMAS DI BANYUWANGI SEBAGAI PENGUATAN GREEN CONSTITUTION
Authors: Arifin Syamsul , Kholish Moh. Anas , Ma’ali Abul , Mushoffa In'amul
Published: April 2023

Penelitian ini dilakukan untuk mempelajari (1) Bagaimana potret kerusakan ekologi yang diakibatkan oleh pengelolaan tambang emas di Banyuwangi? (2) Bagaimana jihad ekologis kaum bersarung terkait pengelolaan sumber daya alam yang ramah lingkungan sebagai penguatan green constitution dalam menyikapi penambangan emas di Banyuwangi? Penelitian ini menghasilkan temuan bahwa: Pertama, Penambangan emas di Banyuwangi telah menyebabkan pencemaran udara dan laut/pantai, kerusakan jalan, banjir lumpur, merentankan kawasan rentan tsunami di pesisir selatan wilayah Banyuwangi. Kedua, berbagai upaya jihad atau aksi bernuansa religius seperti istighasah, doa bersama, membaca hizb nashar sebagai bentuk jihad ekologis kaum bersarung dalam penyelamatan lingkungan belum berhasil menyelamatkan kawasan Gunung Tumpang Pitu dan Gunung Salakan dari eksploitasi tambang. Kondisi ini menyiratkan semakin pentingnya konstitusionalisasi hijau model struktural dengan memberikan hak alam (right of nature) atau memperlakukan alam sebagai subjek hukum dalam norma UUD NRI 1945.
Pengelolaan Keragaman dan Penanganan (In)Toleransi
Authors: Rohman M. Saifullah
Published: April 2023

Dikenal sebagai kota toleran, Yogyakarta merupakan kota yang ramah terhadap keberagaman dan terbuka bagi seluruh kelompok atau golongan. Meskipun demikian, masih ada beberapa kejadian intoleransi, seperti diskriminasi di ranah pendidikan, kasus rumah ibadah hingga kebijakan yang dianggap cenderung diskriminatif terhadap kelompok minoritas. Berbagai upaya telah dilakukan oleh pemerintah maupun masyarakat untuk menjaga dan mengelola keragaman tersebut dengan mempromosikan toleransi dalam berbagai kegiatan formal maupun informal. Penelitian ini merupakan sebuah penelitian kualitatif dengan pendekatan studi kasus. Kasus sengketa dan penyerangan rumah ibadah di Yogyakarta menjadi objek penelitian untuk melihat bagaimana pengelolaan keragaman dan penanganan ataupun pengelolaan toleransi dan intoleransi di Yogyakarta. Kemudian, pengelolaan ruang keagamaan dan kohesi sosial masyarakat di wilayah Kota Baru, Yogyakarta menjadi amatan dalam melihat model positif dari toleransi. Hasil dari studi ini memperlihatkan bahwa 1) Quick respons pemerintah daerah maupun masyarakat terhadap beberapa kejadian intoleransi dilakukan agar konflik tidak tereskalasi 2) Penguatanan relasi sosial-keagamaan menjadi faktor utama dalam pengelolaan keragaman di Yogyakarta. Beberapa situs bangunan keagamaan, seperti gereja dan masjid di wilayah Kota Baru Yogyakarta juga menjadi penanda dan pengingat penting akan kuatnya toleransi di Yogyakarta.
MANAJEMEN AKOMODASI SYARIAH DI PULAU LOMBOK
Authors: Suastrini Fatana
Published: April 2023

Halal tourism is a sector in the Islamic economy that is experiencing rapid development. Tourism development on Lombok Island still focuses on the development of natural and cultural tourism. The development of sharia tourism on the island of Lombok is not optimal. The tourism industry is of course very closely related to the accommodation business. Therefore, there is a need for a study on the potential management of sharia accommodation on Lombok Island, West Nusa Tenggara. This research is a descriptive research. According to the NTB MUI, the reason for the lack of sharia accommodation was triggered because many hotels were afraid that their guests would disappear after their hotels obtained the legality of a halal certificate. In fact, sharia accommodation is a very prospective potential in accordance with Lombok's branding as a Halal Tourism Destination. Sharia accommodation management needs to implement facilities and services, both physical and non-physical. Non-physical Islamic service standards, for example: dress etiquette, greeting greetings, congregational prayers for employees, and good and polite behavior when interacting between hotel managers and guests. Physical Islamic services, such as: facilities in guest rooms that provide Qibla direction, ablution facilities, prayer equipment, the Koran, and seats for those who are not muhrim. Apart from preparing several prayer facilities in the room, the room was also set to a size that almost matched the size of the Prophet's room. Other facilities that are of Islamic standard are swimming pool facilities. Swimming pools need to be separated between men's and women's pools. Sharia hotel accommodation restaurant facilities provide halal-standard food that has been certified by the Indonesian Ulema Council.
MANAJEMEN LOGISTIK HALAL
Authors: Suastrini Fatana
Published: April 2023

Now people's choice has changed from choosing cheap and healthy products to products that are safe, healthy and halal. Because in addition to guaranteed sharia, the product is likely to contain blessings. The management system that regulates the distribution and storage of these products is called the halal logistics system. Problems in halal logistics are caused by low international halal certification, unclear halal guidelines, cooperation and funding, low demand and low standards to measure cost-effectiveness. Based on this description, a study was conducted on halal logistics management. This research is a descriptive research using review method and literature study. The basic concepts of general logistics and halal logistics are actually the same, the difference is that halal logistics is implemented by ensuring the supply chain process separates halal cargo from non-halal cargo. This must be done to avoid cross-contamination and to ensure that during the logistics system the products are halal. When this is done, it will produce halal logistics output that meets the standards desired by the customer. To ensure that the logistics process is always halal, a Halal Assurance System (HAS) is required which is implemented by logistics service providers. One of the emerging technological innovations related to halal logistics is blockchain. the blockchain system will facilitate the separation of the halal industry from halal and haram products and facilitate the implementation of digital transactions and contracts.
CONFLITOS POR ÁGUA E OS (DES) CAMINHOS DO USO E APROPRIAÇÃO NO CONTEXTO DO SEMIÁRIDO
Authors: Silva Cícero da
Published: April 2023

Objetivamos com este escrito a realização de uma breve análise quanto à problemática dos conflitos por água no Brasil com ênfase na região semiárida. Para isso aborda-se no centro da discussão os fundamentos da Política Nacional de Recursos Hídricos (PNRH), instituída pela Lei 9.433 de 8 de janeiro de 1997. Para a análise, fizemos uso de uma metodologia quanti-qualitativa, em que as bases ancoram-se no levantamento teórico-conceitual, nos dados disponibilizados pela Comissão Pastoral da Terra (CPT) entre os anos de 2009 a 2018 e na Politica Nacional de Recursos Hídricos. Como resultados obteve-se o total de casos de conflitos por água e de famílias atingidas no Brasil e na espacialidade da região semiárida. Verificou-se ainda que no semiárido a “linha” de conflitos está diretamente associada às águas sanfranciscanas, seja no interior da bacia ou nos canais artificias.
ANÁLISE DAS TRANSFORMAÇÕES AMBIENTAIS DA PORÇÃO CENTRAL DO ESTADO DO TOCANTINS: ÊNFASE NOS ASPECTOS DE USO E OCUPAÇÃO DA TERRA NO MUNICÍPIO DE BREJINHO DE NAZARÉ
Authors: Cristo Sandro Sidnei Vargas de , Noleto José Paulo da Silva
Published: April 2023

O presente trabalho refere-se à análise das transformações ambientais da porção central do estado do Tocantins, dando-se ênfase aos aspectos de Uso e Ocupação da Terra do município de Brejinho de Nazaré entre os anos de 1985 a 2015. Neste sentido tem como principal objetivo verificar as transformações que ocorreram no ambiente do município em questão, relacionados aos diferentes modos de Uso e Ocupação da Terra. Como método optou-se pelas técnicas de Sensoriamento Remoto onde fez-se uso de imagens de satélites Landsat, sensor TM (Thematic Mapper) dos anos de 1985, 1995 e 2005 e do sensor OLI (Operational Land Imager) do ano de 2015, ambas com resolução espacial de 30 metros, obtidas gratuitamente via site do USGS - United States Geological Survey. Os softwares utilizados foram QGIS versão 2.18.2, Spring versão 5.5 do INPE e o ArcGis Desktop versão 10.5.1 da ESRI. De maneira geral, os resultados proporcionaram observar significativas transformações ambientais no município de Brejinho de Nazaré em decorrência do Uso e Ocupação da Terra, no período em questão, destacando-se principalmente a redução da vegetação de Cerrado em prol das atividades agropecuárias desenvolvidas. Destaca-se também a importância do uso das técnicas de Sensoriamento Remoto para analisar a evolução das transformações ambientais e os aspectos de Uso e Ocupação da Terra como ferramenta de gestão ambiental e planejamento de uso, que pode ser utilizado pelos gestores locais.
O PAPEL DO ESTADO E A FORMAÇÃO DE ESPAÇOS HIBRIDOS DE INOVAÇÃO EM CIDADES MÉDIAS BRASILEIRAS
Authors: Serafim Gomes Maria Terezinha
Published: April 2023

RESUMO: Nos últimos anos, os países emergentes, como o Brasil, inseriram em suas agendas governamentais a inovação, sendo assim, ela passa a fazer parte de políticas públicas, incentivando a implantação de ambientes de inovação, como parques tecnológicos e incubadoras tecnológicas. Desde modo, a partir de 2003, a inovação passa ser prioridade nas políticas públicas no âmbito do governo federal, entre elas: a Lei de Inovação (Lei 10.973/2004), o Programa Nacional de Apoio às Incubadoras de Empresas e Parques Tecnológicos (PIN), em 2005, visando fomentar a consolidação e o surgimento de parques tecnológicos e incubadoras de empresas, o PACTI - Plano de Ação Ciência, Tecnologia e Inovação para o Desenvolvimento Nacional (2007-2010), visando o papel decisivo da ciência e tecnologia no desenvolvimento sustentável do país, além do Política o Plano Brasil Maior, em 2011, visando o estímulo à competitividade, o investimento, à inovação tecnológica e à produção nacional para alavancar a competitividade da indústria nos mercados interno e externo, entre outras ações e iniciativas. No âmbito do estado de São Paulo foi criado em 2006, o Sistema Paulista de Parques Tecnológicos, fomentar, impulsionar e apoiar as iniciativas de criação e implantação dos parques tecnológicos. Este artigo tem como objetivo compreender o papel do estado na formação de espaços híbridos da Inovação em cidades médias brasileiras, em particular na região Oeste do Estado de São Paulo. Para tanto, pautou-se na revisão bibliográfica, na coleta de dados e informações junto aos órgãos públicos e privados (IBGE, SEADE, SEDEC, APETI, Prefeitura Municipal), além da realização de pesquisa de campo junto ao Centro de Incubadora de Empresas e Parque Tecnológico, na cidade de São José do Rio Preto.
GLOBALIZAÇÃO E CIRCUITO ESPACIAL URBANO DA COSTURA: A INDÚSTRIA DE CONFECÇÃO EM FORTALEZA-CEARÁ
Authors: Santos Marlon Cavalcante , Silva José Borzacchiello , Bezerra Eciane Soares
Published: April 2023

Na presente pesquisa analisa-se as relações globais da indústria de confecção, tento como suporte a teoria dos circuitos da economia urbana, superior e inferior, como reflexão teórica para abordagem do tema. Dentro da reflexão dos circuitos da economia urbana, aprofunda-se a leitura da estrutura e a articulação espacial das firmas e das indústrias de confecção a nível global, buscando-se relacionar com a presença das mesmas no município de Fortaleza e sua importância para geografia econômica urbana.  Evidencia-se as novas formas, funções, estruturas e processos que o ramo da produção e de circulação de confecção passou a partir do regime de Acumulação Flexível em ação mais intensamente a começar nos 1970. Metodologicamente analisou-se referência bibliográfica que trata sobre o tema, como pesquisa em banco de dados em instituições públicas: Prefeitura de Fortaleza, SEFAZ-CE e privadas, FIEC entre outras. De porte de dados e informações, aliou-se o trabalho de campo para assim estruturar uma reflexão do tema hora proposto. A explanação divide-se em três partes, introdução, explanação do objeto estudado e considerações finais, na qual faz-se uma análise interescalar das firmas e das indústrias de confecção no espaço geográfico globalizado no município de Fortaleza, almejando as articulações que esse circuito produtivo estrutura no espaço, principalmente no urbano de países não desenvolvidos, notadamente países da Ásia como China e Bangladesh e da América Latina tal como Brasil, Peru entre outros que são responsável pela produção e circulação de material confeccionado.
Thoracoscopic Repair of Esophageal Atresia
Authors:   University Children’s Hospital of Basel, Switzerland, Department of Pediatric Surgery, Vuille-dit-Bille Raphael , Muff Julian , Holland-Cunz Stefan ,   University Children’s Hospital of Basel, Switzerland, Department of Pediatric Surgery
Published: April 2023

The surgical repair of esophageal atresia is one of the most difficult and challenging procedures in pediatric surgery. The operation can either be performed in a classic extrapleural open manner via a posterolateral thoracotomy or in a minimally invasive thoracoscopic manner. While good comparative studies are lacking due to the small and heterogeneous patient cohort, there is currently no good evidence for or against the thoracoscopic method. Arguments for open surgery may consist of shorter operation time, and avoidance of the intrapleural space. On the other hand, there could be fewer patients with later scoliosis, thoracic wall defects and winged scapula following thoracoscopic repair. We hereby offer a detailed and step-by-step guide to performing thoracoscopic surgery for esophageal atresia. Using two or more thoracoscopic sliding knots which are tightened one by one in small increments step by step, the two esophagus ends may be brought together, whereby the pull is distributed to different points of the esophagus. Explaining several tricks and pitfalls, this video is intended to serve as a guide for experienced pediatric surgeons to optimally and timely carry out this difficult operation.
A Reaction Drive Powered by External Dynamic Pressure
Authors:   Electric Sky, Inc, Greason Jeffrey
Published: April 2023

A new class of reaction drive is discussed, in which reaction mass is expelled from a vehicle using power extracted from the relative motion of the vehicle and the surrounding medium, such as the solar wind. The physics of this type of drive are reviewed and shown to permit high velocity changes with modest mass ratio while conserving energy and momentum according to well-established physical principles. A comparison to past propulsion methods and propulsion classification studies suggests new mission possibilities for this type of drive. An example of how this principle might be embodied in hardware suggests accelerations sufficient for outer solar system missions, with shorter trip times and lower mass ratios than chemical rockets. Keywords: Propulsion, Reaction drive, Solar wind, External power, Dynamic pressure
Colliding Pandemics and CoViD-19
Authors: Chiappelli Francesco
Published: April 2023

Cases of the respiratory syncytial virus (RSV), monkeypox virus (MPXV), and avian influenza A Virus (IAV) have increased during our current prolonged Corona Virus Disease 2019 (CoViD-19) pandemic. The rise of these viral infectious diseases may be associated or even inter-dependent with acute, latent or recurrent infection with Systemic Acute Respiratory Syndrome Corona virus-2 (SARS-CoV2). The nonsensical neologism 'tripledemic' was tentatively introduced to describe the confluent nature of these trends (epidemic comes from two Greek words: epi=on, about, demos=people; pandemic is also derived from Ancient Greek: pan=all, demos=people; but 'tripledemic' would derive from Latin triplus=three, Greek demos=people, and would at best signify 'three countries, three peoples', but certainly not the current threat of confluence of three, or perhaps more pandemics). Emerging evidence suggests that monkey pox and CoViD-19, among several other viral diseases, produce significant observable manifestations in the oral cavity. From a clinical standpoint, dentists and dental personnel may be among the first health professionals to encounter and diagnose clinical signs of converging infections. From the immune surveillance viewpoint, viral recombination and viral interference among these infectious diseases must be examined to determine the potential threat of these colliding pandemics.
Molecular docking analysis of PET with MHET
Authors: Uday J
Published: April 2023

An estimated 311 million tons of plastics are produced annually worldwide; 90% of these are derived from petrol. A considerable portion of these plastics is used for packaging (such as drinking bottles), but only ~14% is collected for recycling. Most plastics degrade extremely slowly, thus constituting a major environmental hazard, especially in the oceans, where microplastics are a matter of major concern. One potential solution for this problem is the synthesis of degradable plastics from renewable resources. From the microbial consortium, the researchers isolated a unique bacterium Ideonella sakaiensis 201-F6 that could almost completely degrade a thin film of PET in a short span of six weeks at 30°C. The objective of the present study is to identify the ligands that may be exploited to improve catalysis and expand substrate specificity and thus significantly advance enzymatic plastic polymer degradation.
Fingerprint patterns in neuropsychological disorder depression among south Indian population
Authors: Krishnan Madhan
Published: April 2023

Depression is a pervasive mental health disorder characterized by persistent sadness and an inability to enjoy activities that were once enjoyable. This study compares the dermatoglyphic patterns of depressed patients with those of healthy, normal individuals in order to determine if dermatoglyphic patterns can be used as biomarkers for early diagnosis and prompt intervention of depression. A total of 100 depressive disorder patients of both sexes between the ages of 18 and 60 were selected for the study. Dermatoglyphic patterns of individual digits were analyzed using the "Ink and Paper" technique. The Whorl, Loop, and Arch patterns, as well as the AFRC, TFRC, and a-b ridge count, were examined using One-Way ANOVA significance and a Chi-Square test using SPSS 20.0. The results showed that the right hand in the depressive diseased group had decreased numbers of Whorls in the 2nd and 5th digits, and decreased numbers of Loops in all five digits. Similarly, decreased numbers of Whorls were found in the 1st, 2nd, 4th, and 5th digits of the left hand, as well as decreased Loops in the 4th digit. However, there were no changes in the Arches of either hand when compared to the control group. The AFRC and TFRC were significantly decreased (p<0.0001), but there was no significant decrease in the a-b ridge count in the depressive diseased group when compared to the control group. Dermatoglyphics, a noninvasive method, can serve as a screening indicator for depressive individuals, the appearance of the decreased count of whorls and loops parameters might be used as an exploratory sign.
Is self-testing the next paradigm for diagnostics?
Authors: Pawar Shrikant
Published: April 2023

The study estimates the usability and attitude assessment of users for India’s first approved rapid antigen self-test kit; the CoviSelf™. India approved its first AI-powered self-test for Covid-19 in April 2021 a few weeks after the first approval in the US. We present here a study on usability and attitude assessment of users of India’s first approved rapid antigen self-test kit; the CoviSelf™. The study evaluates participants’ understanding of and performance of test procedure and interprets the results. Analysis revealed that more than 90% study participants followed steps correctly as illustrated in the user’s manual. Age group and gender-based analysis showed comparable scores for usability of the test kit suggesting users of different age groups has same ease in using the test kit. What we learnt from this study could be start of self-test revolution, where rapid tests could expand the access of diagnostics for hundreds of diseases including HIV, HPV, and dengue to millions of people who could not get access to diagnostics because we lacked manpower or facility to conduct tests. Self-testing could break the barriers for diagnostics that Internet did for information.
Molecular docking analysis of AGTR1 antagonists
Authors: Alam Qamre
Published: April 2023

Cardiovascular diseases (CVDs) are the leading cause of death and morbidity globally. The renin-angiotensin system is an important regulatory system for maintaining cardiovascular and renal function. Therefore, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have emerged as first-line treatments for conditions such as hypertension and heart failure. Currently available synthetic medications used to treat various CVDs have been linked with various adverse effects. Therefore, this study focuses on targeting type-1 angiotensin II receptor (AGTR1) by natural compounds. The ZINC database natural compounds and standard AGTR1 inhibitors have been screened against the AGTR1 active site. The results showed that five compounds, namely ZINC85625504, ZINC62001623, ZINC70666587, ZINC06624086, and ZINC95486187, had similar binding energies to established AGTR1 inhibitors. These compounds were found to interact with crucial AGTR1 residues, indicating their potential as AGTR1 inhibitors. Moreover, the hit compounds demonstrated favorable drug-like characteristics and warrant further investigation for their potential use in managing CVD.
Feedback on dental implants with dynamic navigation versus freehand
Authors: Nirula Pragati
Published: April 2023

The Aim of the study is to understand and identify if Dynamic Navigation (DN) has an upper hand to provide ease and comfort to the patients during and after surgery. 60 patients requiring 120 Implants, were randomly allocated in 2 groups (Group 1- Freehand surgery, Group 2- Dynamic navigation surgery) requiring dental implant therapy. Patients in both the groups were given a Patient satisfaction questionnaire assessing the following domains: comfort, fear, prior experience with robotics, dental anxiety and pain perception. Patient related Experience measures (PREM’s) were assessed using the following domains: experience with robotics, pain perception and comfort of using various instrumentations during the surgery. The pre and post CBCT were compared using EVALUNAV application of the Navident software. There was significant difference (p<0.05) between the two groups in the patient outcomes pertaining to the future of robotics in medicine (group 1: 2±1.259, group 2 :4.8±0.484) and Patients reliability to a specific procedure due to the less surgical time taken (group 1:3.3±0.651, group 2: 4.63±0.556). The post-operative pain between the groups was also assessed with VAS scale.
An update on diagnosis and therapeutics for type-2 diabetes mellitus
Authors: Babu Shyamaladevi
Published: April 2023

Type-2 Diabetes mellitus is a common metabolic disorder and is combined with co-morbidities, such as obesity, hyperlipidemia, hypertension and cardiovascular disease which taken together, comprise the ‘Metabolic Syndrome’. This disease causes crucial morbidity and mortality at considerable expense to patients, their families and society. Different categories of drugs such as insulin secretagogues, insulin sensitizers, alpha-glucosidase inhibitors, GLP-1 agonists, DPP4 inhibitors, Dual PPAR agonists etc are used for its management. In this review, we have highlighted the recent advances in diagnosis and therapeutics used in the treatment of type-2 diabetes mellitus. The classical and online-literature were studied in order to compile the data which includes the electronic search engine such as Scopus, Google Scholar, Sci Finder, PubMed and Web of Science etc. The scientific data showed that at present, there are different families of oral and injectable drugs are at hand for the treatment of T2DM which has deleterious side effects. Hence, we need to develop a novel, safety and effective agents that will improve the quality of life of T2DM patients, considering the properties of the treatment such as effectiveness and durability of lowering blood Glucose, risk of hypoglycemia and diabetes complications.
A short note on hypertension management
Authors: Babu Shyamaladevi
Published: April 2023

Hypertension occupies a unique position in public health care, because it is the major cause of cardiovascular disease and the most frequent non-communicable disorder seen in primary care globally. The prevalence, treatment, and control rates of hypertension vary greatly by ethnicity. Such disparities are mostly linked to genetic variances, although lifestyle and socioeconomic level may influence health behaviours such as food - both of which appear to be substantial factors. East Asian communities have distinct ethnic traits. Hypertensive individuals are more likely to have salt sensitivity together with modest obesity. East Asians have a greater prevalence of stroke (especially hemorrhagic stroke) and no ischemic heart failure (HF) than Westerners. These problems are typical in both untreated and treated hypertensive patients. White coat hypertension affects 10%–30% of people who visit clinics for high blood pressure, whereas masked hypertension affects 10%–15% of people .With substantial hypertension populations in India and China, clinical studies in these areas are necessary to determine whether existing treatment techniques are effective. All patients with suspected or confirmed hypertension should receive regular lifestyle advice from their doctors, including recommendations for diet and exercise. Expert counsel and more frequent monitoring might be necessary.
Anti-quorum sensing activity of Boerhavia diffusa against Pseudomonas aeruginosa PAO1
Authors: Babu Shyamaladevi
Published: April 2023

Quorum sensing (QS) is one of the key virulence factors in Pseudomonas aeruginosa and causes recalcitrant infections. Multi-drug resistance and biofilm formation seem to be regulated by cell-to-cell communication system through QS. Thus this study is aimed to assess the efficacy of ethanolic leaf extract of Boerhavia diffusa in acting against the QS-regulated virulence traits. Fresh leaves of B. diffusa were dried and the ethanolic crude extract was checked for antimicrobial and anti biofilm effect against P. aeruginosa. The active components and the biological structures were elucidated by GC-MS, HPLC and NMR analysis respectively. Further, computational analyses were also performed to assess the drug ligand interactions based on the docking scores and binding energy. The results suggested that the MIC concentration showed a significant effect in inhibiting the QS network circuit of P. aeruginosa. The docking results showed that leaf had bioactive compounds that exhibit strong binding affinity towards transcriptional activators of the QS circuit in P. aeruginosa, i.e., LasR, as compared to the natural ligands, 3-oxo-C12-HSL and C4-HSL. These results clearly depictthe efficacy of Boerhavia diffusa and its phyto-constituents as promising QS antagonist which can be further applied in the treatment strategies for the diseases caused by P. aeruginosa.
Micro RNA210 expression in pregnancies with preeclampsia
Authors: Gopi Keerti
Published: April 2023

Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia.
Insights from the molecular docking and simulation analysis of P38 MAPK phytochemical inhibitor complexes
Authors: Prasada Rao Chennu MM
Published: April 2023

It is of interest to develop p38α MAPK inhibitors. Docking, ADMET properties calculation, molecular dynamics, and MM-PBSA approaches were used to investigate the therapeutic potentials of p38α MAPK in complex with SB203580 (1A9U). The photo-molecules metergoline, withaphysacarpin, philadelphicalactone, canthin-6-one 9-glucoside, and SB-21600011 demonstrated high binding affinity compared to the reference drug. Furthermore, ADME profiles validated the drug-like properties of the prioritized phyto-compounds. Besides that, MD simulations were performed along with reference inhibitors for withaphysacarpin and metergoline to assess stability. Binding free energy calculations (MM-PBSA) revealed that metergoline and withaphysacarpin had estimated values (G) of 97.151 ± 21.023 kJ/mol and -82.084 ± 15.766 kJ/mol, respectively. In this study, metergoline and withaphysacarpin were found to have high affinity against p38α MAPK when compared to the reference compound SB 203580.
Meta-analysis of lean and obese RNA-seq datasets to identify genes targeting obesity
Authors: Prabhakar Lavanya
Published: April 2023

Obesity is a global crisis leading to several metabolic disorders. Modernization and technology innovation has been easier for next generation sequencing using open-source online software galaxy, which allows the users to share their data and workflow mapping in an effortless manner. This study is to identify candidate genes for obesity by performing differential expression of genes. RNA-Seq analysis was performed for six different datasets retrieved from GEO database. 258 datasets from obese patients and 55 datasets from lean patients were analysed for differentially expressed genes (DEGs). DEGs analysis showed 1971 upregulated genes and 615 downregulated genes with log2FC count ≥ 2.5 and p-value < 0.05. The Gene enrichment analysis performed using Gene Ontology resource highlighted pathways associated to obesity such as cholesterol metabolism, Fat digestion and absorption and glycerolipid metabolism. Using string database protein-protein interactions network was built and the network clusters were visualized using Cytoscape software. The protein-protein interactions of the upregulated and downregulated genes were mapped to form a network, wherein PNLIP (Pancreatic lipase) and FTO (Fat mass and obesity associated protein) gene clusters were visualized as densely connected clusters in MCODE. PNLIP and FTO with its associated genes were identified as candidate genes for targeting obesity.
L’agentivité des jeunes exposés à la violence
conjugale soutenue par la méthode du calendrier historique de vie
Authors: Dumont Annie , Lessard Geneviève , Alvarez-Lizotte Pamela , Pellerin Anaïs , Lapierre Simon
Published: April 2023

Cadre de la recherche : Cet article s’appuie
sur deux études menées auprès de jeunes adultes ayant vécu l’exposition à la violence
conjugale (EVC) dans l’enfance ou l’adolescence. Ces études s’intéressaient à leur
parcours de vie et au regard qu’ils portaient sur la violence conjugale.

Objectifs : L’article documente les types
d’agentivité mis en œuvre par les jeunes interrogés, à travers leur parcours de vie. Il
explore aussi dans quelle mesure l’utilisation du calendrier historique de vie (CHV) dans
la recherche peut favoriser la reprise de pouvoir de ces jeunes sur la manière de raconter
leur histoire.

Méthodologie : Des entrevues qualitatives
semi-dirigées, soutenues par le CHV, ont été réalisées avec 63 jeunes de 18 à 25 ans ayant
été exposés à la violence conjugale. L’analyse de leur agentivité s’est faite à partir de
la typologie d’Hitlin et Elder (2007).

Résultats : Les stratégies d’agentivité
identitaire décrites par les participants se rapportent beaucoup aux actions les aidant à
se protéger de la violence dans leur quotidien. Les stratégies d’agentivité pragmatique et
du parcours de vie leur permettent quant à elles de faire face à des situations nouvelles
et à se projeter dans un avenir meilleur. Leur participation à la recherche fait partie de
leurs stratégies agentives.

Conclusions : Le regard rétrospectif adopté par
les participants les amène à décrire le sens qu’ils donnent aux stratégies agentives
utilisées pour contrer l’expérience d’EVC et ses conséquences à court et à long terme. En
plus de générer de nouvelles connaissances sur l’EVC, la méthodologie de l’étude favorise
une réappropriation de leur récit de vie par les jeunes concernés, qui peuvent expliquer
le sens de leurs actions ou décisions.

Contribution : Le fait de
considérer les jeunes ayant vécu l’EVC comme des acteurs de leur parcours de vie contribue
à leur donner une voix et à prendre en compte leur point de vue dans les décisions qui les
concernent.
Identités fantômes : communautés et patrimoine territorial en Acadie du Nouveau-Brunswick
Authors: Wade Mathieu
Published: April 2023

L’Acadie ne possède pas d’État propre, mais elle occupe des territoires. Pendant près de deux siècles, de la seconde moitié du 18e siècle aux années 1930, des centaines de localités acadiennes ont été établies dans les provinces maritimes et tout particulièrement au Nouveau-Brunswick. Ces localités ont historiquement délimité les frontières de la communauté ethnolinguistique acadienne et se sont explicitement inscrites dans le projet nationaliste de la seconde moitié du 19e siècle. Or, à partir des années 1950, le modèle territorial acadien est entré en crise et on a assisté à une désinstitutionnalisation des communautés. Cet article porte sur les transformations de l’ancrage territorial en retraçant la dynamique de peuplement et en interrogeant la persistance de frontières locales dans un contexte où elles ne renvoient plus à des communautés vivantes. Pour ce faire, nous proposons une lecture critique du patrimoine local à partir d’une analyse des monographies paroissiales et de la morphologie des communautés.
Le modelé d’érosion glaciaire de l’île d’Anticosti révélé par l’imagerie LiDAR
Authors: Hétu Bernard , Bernatchez Pascal , Dubé Jérôme
Published: April 2023

Des images LiDAR à haute résolution dévoilent des modelés d’érosion glaciaire inédits qui nuancent fortement les interprétations publiées antérieurement concernant l’histoire glaciaire de l’île d’Anticosti. Sculptées dans le roc, ces formes d’érosion glaciaire sont très diversifiées : lacs de surcreusement glaciaire, drumlins rocheux, cannelures géantes, mégaqueues-de-rat, dalles de roc déplacées par les glaciers. Bien que pour la plupart discrètes, ces formes d’érosion glaciaire sont présentes partout sur l’île. Toutefois, c’est dans les basses terres de l’est et de l’ouest que l’empreinte glaciaire est la plus forte. Dans les basses terres de l’est, l’écoulement glaciaire vers le sud-ouest, observé partout sur l’île, a été suivi par un écoulement vers le sud-est. Ces 2 écoulements avaient leur source sur le Bouclier canadien (inlandsis laurentidien). Un écoulement tardif vers le nord a été observé dans la moitié nord du plateau central (au nord de la rivière Jupiter). Cet écoulement vers le nord est attribué à la calotte glaciaire régionale qui a occupé le plateau central durant la déglaciation.
La face cachée des plaidoyers de culpabilité négociés par des entreprises : l’exemple de l’affaire R c SNC-Lavalin
Authors: Manirabona Amissi M , Masson Flavie
Published: April 2023

Dans le présent article, nous nous penchons sur les difficultés découlant des plaidoyers de culpabilité négociés par les entreprises et enregistrés devant les juridictions criminelles canadiennes. Nous partons de la décision relative au plaidoyer de culpabilité survenu en décembre 2019 entre le ministère public canadien (la Couronne) et la société d’ingénierie montréalaise SNC-Lavalin Construction inc, une filiale du Groupe SNC-Lavalin inc. À cet effet, le texte s’attarde sur les circonstances qui ont entouré ce plaidoyer de culpabilité par cette filiale pour résoudre l’affaire pénale contre la firme d’ingénierie, ainsi que sur les conséquences négatives qui pourraient en découler. De manière plus générale, les problématiques associées aux plaidoyers de culpabilité impliquant les entreprises sont également examinées.
Turkey vs Egypt in the Eastern Mediterranean
Authors: Parlanova Aila Telman kyzy
Published: April 2023

The object of the study is Ankara's foreign policy strategy. The subject of the study is the positions of Turkey and Egypt in the Eastern Mediterranean region. The aim is to identify the possibility of a Turkish–Egyptian alliance in the region after the extremely tense relations recorded since 2013, the establishment in Egypt of a new president A.F. Al-Sisi, the ideological antipode of R.T. Erdogan. The relevance of the study is evidenced by changes in the rhetoric of Turkey's top officials and the demonstration of readiness to build a dialogue with Cairo. Particular attention is paid to Ankara's position on the establishment of maritime borders in the Aegean and Mediterranean Seas on the basis of bilateral agreements. Research methods: analysis of strategies, official documents, logical-heuristic and system methods, as well as analysis of political events in the region.       Based on the analysis of primary sources (foreign policy strategies 2020-2023), it was revealed: since 2020, the Eastern Mediterranean region has been the main vector of Ankara's foreign policy. As noted in the reports of the Ministry of Energy and Mineral Resources, the country is 70% dependent on foreign energy supplies, which explains Ankara's uncompromising position on securing its right to extract gas from the depths of the Eastern Mediterranean. Attempts to restore relations with Egypt are a geopolitical necessity. However, Cairo found itself in the position of Turkey's competitor in an effort to turn into an energy hub when exporting gas from Israel to Europe. Egypt attaches paramount importance to the issue of energy security, which is confirmed by the Egypt Vision 2030 strategy. The most advantageous for Egypt is the preservation of the Egypt-Israel-Greece-Cyprus block. Based on the conducted research, it can be concluded that there is an extremely low probability of a Turkish-Egyptian rapprochement. The findings of the study can be taken into account when studying and forecasting Turkey's foreign policy.
Regulation of the Concept of "Electric Energy Power" in Acts of International Law and Decisions of International Judicial Instances
Authors: Korovin Evgenii Sergeevich
Published: April 2023

The subject of the study is the peculiarities of the regulation of the legal category "electric energy (power)" in international acts (regulatory and judicial). The object of the study is recognized as the international foundations of the legal regulation of the concept of "electric energy (power)", reflected in the sources of international law and in the decisions of international judicial bodies. The purpose of the scientific article is to substantiate the need to unify the norms of international law with a reflection of the generally recognized position regarding the concept of "electric energy (power)" and the formation of the author's vision of the definition of this term.The author examines in detail the positions regarding the understanding of this term in international acts of various international organizations and judicial instances, emphasizes the importance of international unification in this direction, expresses the author's position on the meaning of the dynamically developing spheres of activity and economy of each modern state. Each State is called upon not only to provide its citizens and their collective entities with electric power resources on a safe and uninterrupted basis, but also to implement these functions in international relations regulated by acts of international law. The importance of the unification of the concept of "electric energy (power)" as a tool for the approximation of the legislation of individual countries aimed at fst)" in the acts of international law is designed to ensure both energy security and the identity of national legal regulation by including in the sources of law to the maximum extent textually and essentially similar from a legal point of view categories and their definitions. A special contribution of the author is to conduct a detailed analysis of numerous acts of international law (normative, judicial), which include in their content the concept of "electric energy (power)", the characteristics of various positions, carrying out their comparative characteristics. The novelty of the research is reflected in the formation of an opinion regarding the understanding of the legal category "electric energy (power)", its reflection in the author's definition.