bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Dark side of conscientiousness. The relationship between conscientiousness and its potential derailers: perfectionism and narcissism
Authors: Coleman Geoff , Furnham Adrian , Treglown Luke
Published: November 2022

The current study aimed to identify what individual differences and situational variables cause derailment in highly conscientious people. Data were from a representative working sample of 716 participants across 27 industries, spanning both management and non-management roles. We tested four hypotheses with regard to bright- and dark-side personality traits and the relationship between boss/manager and staff member. Hierarchical linear regressions revealed mixed findings for Leader-Member Exchange (LMX) as a stressor. For maladaptive perfectionism it was confirmed, but not for adaptive perfectionism or narcissism. Results suggest introverts may be more prone to maladaptive perfectionism, even with higher levels of conscientiousness if there are lower LMX levels. Overall, the findings suggest selecting for conscientiousness alone and discounting other personality traits and situational variables may be detrimental in practice. Further implications are discussed alongside the study limitations.
Alteration of monocyte subsets and their functions in thalassemia patients
Authors: Piyajaroenkij Thanakrit , Tantiworawit Adisak , Khikhuntod Jeeraphong , Piriyakhuntorn Pokpong , Rattanathammethee Thanawat , Hantrakool Sasinee , Chai-Adisaksopha Chatree , Rattarittamrong Ekarat , Norasetthada Lalita , Fanhchaksai Kanda , Charoenkwan Pimlak , Thananchai Hathairat
Published: November 2022

Infection is one of the leading causes of mortality in thalassemia patients. This study aimed to examine qualitative and quantitative changes in monocytes in thalassemia patients. Monocytes were isolated from peripheral blood mononuclear cells and separated into subpopulations by flow cytometry. Cytokine levels were measured using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and sandwich enzyme-linked immunosorbent assay (ELISA). The primary endpoint was monocyte-derived TNF-α expression. A total of 78 patients and 26 controls were included. The mean log (TNF-α fold-change) by qRT-PCR was significantly lower in all thalassemia groups, at 1.27 in controls, versus 0.97 (p = 0.0014) in non-transfusion-dependent thalassemia (NTDT), 0.96 (p = 0.0004) in non-splenectomized transfusion-dependent thalassemia (TDT-NS), and 0.87 (p < 0.0001) in splenectomized transfusion-dependent thalassemia (TDT-S). Similarly, the mean 2-h TNF-α level measured by sandwich ELISA assay was significantly lower in all thalassemia groups, at 98.16 pg/mL in controls, versus 56.45 pg/mL (p = 0.0093) in NTDT, 39.05 pg/mL (p = 0.0001) in TDT-NS and 32.37 pg/mL (p < 0.0001) in TDT-S. Likewise, TDT patients had a significantly decreased percentage of non-classical monocytes, by approximately half compared to controls. Our results show that thalassemia major patients have clearly impaired monocyte counts and function.
Neural Correlates of Spatial Navigation in Primate Hippocampus
Authors: Mao Dun
Published: November 2022

The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks.
Regional differences in health further explained
Authors: Meisters Rachelle , Putrik Polina , Westra Daan , Bosma Hans , Ruwaard Dirk , Jansen Maria
Published: November 2022

Like in most Western countries, regional health inequalities are also present in the Netherlands. Explaining these inequalities is necessary for policymakers to target interventions to reduce them. Regional health inequalities are usually attributed to demographic and socio-economic factors, while lifestyle and psychosocial factors are increasingly shown to impact individuals’ health. Therefore, this study analyses the role of lifestyle, loneliness, and self-mastery in explaining regional inequalities, in addition to demographic factors and SES, for self-rated health, presence of chronic diseases, and psychological distress. Analyses are performed in the linked dataset from the Dutch Public Health Services, Statistics Netherlands, and the National Institute for Public Health and the Environment for the year 2016 (n = 334,721). The results show that lifestyle, loneliness and self-mastery contribute to the regional health inequalities in self-rated health and presence of chronic diseases. For psychological distress, both loneliness and self-mastery contribute to the regional health inequalities. Addressing lifestyle and psychosocial factors can offer policymakers additional pathways to bridge regional health inequalities. In this study, the region of Zuid-Limburg represents the reference region. Use compare regions for health and healthcare costs (Regiovergelijker gezondheid en zorgkosten [1]) in order to select all other Dutch regions as reference region.
A data driven Dantzig–Wolfe decomposition framework
Authors: Basso Saverio , Ceselli Alberto
Published: November 2022

We face the issue of finding alternative paradigms for the resolution of generic Mixed Integer Programs (MIP), by considering the perspective option of general purpose solvers which switch to decomposition methods when pertinent. Currently, the main blocking factor in their design is the problem of automatic decomposition of MIPs, that is to produce good MIP decompositions algorithmically, looking only at the algebraic structure of the MIP instance. We propose to employ Dantzig–Wolfe reformulation and machine learning methods to obtain a fully data driven automatic decomposition framework. We also design strategies and introduce algorithmic techniques in order to make such a framework computationally effective. An extensive experimental analysis shows our framework to grant substantial improvements, in terms of both solutions quality and computing time, with respect to state-of-the-art automatic decomposition techniques. It also allows us to gain insights into the relative impact of different techniques. As a side product of our research, we provide a dataset of more than 31 thousand random decompositions of MIPLIB instances, with 121 features, including computations of their root node relaxation.
Testimonial Injustice: The Facts of the Matter
Authors: Arcila-Valenzuela Migdalia , Páez Andrés
Published: November 2022

To verify the occurrence of a singular instance of testimonial injustice three facts must be established. The first is whether the hearer in fact has an identity prejudice of which she may or may not be aware; the second is whether that prejudice was in fact the cause of the unjustified credibility deficit; and the third is whether there was in fact a credibility deficit in the testimonial exchange. These three elements constitute the facts of the matter of testimonial injustice. In this essay we argue that none of these facts can be established with any degree of confidence, and therefore that testimonial injustice is an undetectable phenomenon in singular instances. Our intention is not to undermine the idea of testimonial injustice, but rather to set limits to what can be justifiably asserted about it. According to our argument, although there are insufficient reasons to identify individual acts of testimonial injustice, it is possible to recognize recurrent patterns of epistemic responses to speakers who belong to specific social groups. General testimonial injustice can thus be characterized as a behavioral tendency of a prejudiced hearer.
Himalayan alpine ecohydrology: An urgent scientific concern in a changing climate
Authors: Leng Ruolin , Harrison Stephan , Anderson Karen
Published: November 2022

Climate change is projected to have important impacts on snow and vegetation distribution in global mountains. Despite this, the coupling of ecological shifts and hydrological processes within alpine zones has not attracted significant scientific attention. As the largest and one of the most climatically sensitive mountain systems, we argue that Himalayan alpine ecohydrological processes require urgent scientific attention because up to 1.6 billion people rely on water supplies from the mountains. We review studies from global mountain systems to highlight the importance of considering ecohydrological impacts within Himalayan alpine zones (4100–6000 m.a.s.l), explaining mechanisms for interactions between snow and dwarf plants. Our findings highlight the paucity of monitoring stations within Himalayan alpine systems. We suggest that it is likely that alpine ecological shifts will impact hydrological processes, but we found that specific mechanisms and functional relationships are missing for Himalayan systems, so the strength and direction of ecohydrological relationships is currently unknown. We advocate for more purposeful and widespread monitoring efforts below glaciers and above the treeline, calling for new experiments to query the role of small plants within the Himalayan alpine hydrological system. We outline the need for community engagement with alpine ecohydrological experiments, and we explain how new snow and vegetation products derived from remote sensing observations have the potential to improve scientific understanding of the interacting effects of warming and ecohydrological factors in this sensitive region.
CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
Authors: Frontiñán-Rubio Javier , Llanos-González Emilio , García-Carpintero Sonia , Peinado Juan Ramón , Ballesteros-Yáñez Inmaculada , Rayo Margarita Villar , de la Fuente José , Pérez-García Víctor M. , Perez-Romasanta Luis A. , Malumbres Marcos , Alcaín Francisco J. , Durán-Prado Mario
Published: November 2022

Purpose

Most monotherapies available against glioblastoma multiforme (GBM) target individual hallmarks of this aggressive brain tumor with minimal success. In this article, we propose a therapeutic strategy using coenzyme Q10 (CoQ10) as a pleiotropic factor that crosses the blood–brain barrier and accumulates in cell membranes acting as an antioxidant, and in mitochondrial membranes as a regulator of cell bioenergetics and gene expression.

Methods

Xenografts of U251 cells in nu/nu mice were used to assay tumor growth, hypoxia, angiogenesis, and inflammation. An orthotopic model was used to explore microglial infiltration, tumor growth, and invasion into the brain parenchyma. Cell proliferation, migration, invasion, proteome remodeling, and secretome were assayed in vitro. Conditioned media were used to assay angiogenesis, monocyte chemoattraction, and differentiation into macrophages in vitro.

Results

CoQ10 treatment decreased tumor volume in xenografts and orthotopic models, although its effect on tumor cell proliferation was not direct. Tumors from mice treated with CoQ10 were less hypoxic and vascularized, having less infiltration from inflammatory cells. Treatment-induced downregulation of HIF-1α and NF-kB led to a complete remodeling of the tumor cells proteome and secretome, impacting angiogenesis, monocyte infiltration, and their differentiation into macrophages. Besides, tumor cell migration and invasion were drastically restricted by mechanisms involving modulation of the actin cytoskeleton and downregulation of matrix metalloproteases (MMPs).

Conclusions

CoQ10 has a pleiotropic effect on GBM growth, targeting several hallmarks simultaneously. Thus, its integration into current treatments of this fatal disease should be considered.
Liminalität, Transdifferenz und Geschlecht: Sprachliche Praktiken jenseits von Zweigeschlechtlichkeit
Authors: Lind Miriam
Published: November 2022

Die soziale Differenz Geschlecht und ihre sprachliche Repräsentation ist im deutschen Kulturraum binär organisiert. Für geschlechtliche Positionierungen jenseits der Kategorien Frau und Mann ist in der hegemonialen Geschlechterordnung und ihren sprachlichen Reflexen – bisher – kein Platz vorgesehen. Mit der zunehmenden Sichtbarkeit nichtbinärer Geschlechter wächst jedoch der Bedarf nach ihrer Versprachlichung. Der Beitrag erörtert mit Bezug auf die anthropologischen bzw. kulturwissenschaftlichen Konzepte der Liminalität und Transdifferenz die Probleme und Potenziale der sprachlichen Veruneindeutigung von Geschlecht und der neologistischen Kreativität, mit der neue Bezeichnungsmöglichkeiten außerhalb der Zweigeschlechtlichkeit geschaffen werden.
Conjectures of Sun About Sums of Polygonal Numbers
Authors: Bringmann Kathrin , Kane Ben
Published: November 2022

In this paper, we consider representations of positive integers as sums of generalized m-gonal numbers, which extend the formula for the number of dots needed to make up a regular m-gon. We mainly restrict to the case where the sums contain at most four distinct generalized m-gonal numbers, with the second m-gonal number repeated twice, the third repeated four times, and the last is repeated eight times. For a number of small choices of m, Sun conjectured that every positive integer may be written in this form. By obtaining explicit quantitative bounds for Fourier coefficients related to theta functions which encode the number of such representations, we verify that Sun’s conjecture is true for sufficiently large positive integers. Since there are only finitely many choices of m appearing in Sun’s conjecture, this reduces Sun’s conjecture to a verification of finitely many cases. Moreover, the bound beyond which we prove that Sun’s conjecture holds is explicit.
Analytical methods, molecular structures and biogeochemical behaviors of dissolved black carbon
Authors: Chen Yalan , Sun Ke , Wang Zhibo , Zhang Enyao , Yang Yan , Xing Baoshan
Published: November 2022

Dissolved black carbon (DBC) is one of the most active fractions in the black carbon (BC) continuum and plays a significant role in the global dissolved organic matter (DOM) pool. Connecting the BC pool between territorial and marine environments, the biogeochemical processes of DBC are significant for many aspects of aquatic chemistry. Once entering the aquatic environment, DBC will undergo degradation and exert continuing effects on water ecology. DBC can change the migration and transport of pollutants and affect associated microbial communities. Therefore, the knowledge of the fate and transport of DBC is of great importance. In this work, the molecular structures of different DBC were examined and summarized to provide a basis for understanding the environmental processes of DBC. Current research progress on the photodegradation of DBC, interactions between DBC and microorganisms, and the effects of DBC on the fate and transport of contaminants were critically reviewed. The qualitative and quantitative analytical methods for DBC were assessed in detail. To date, the environmental behaviors of DBC are far from fully understood in part due to the lack of systematic methods. Compared with the relatively well-studied photodegradation of DBC, microbial transformation of DBC is poorly understood. Moreover, DBC is exposed to continuous light illumination and microbial metabolization, thus the combined effects of photodegradation and biodegradation are crucial to the cycling and turnover of DBC in aquatic environment and deserve further investigations. In addition, research on the sorption processes, redox reactions and DBC-assisted photo-transformations of contaminants is still at its emerging stages.
Translingual Discrimination
Authors: Dovchin Sender
Published: November 2022

Moving beyond two main concepts of 'interlingual' and 'intralingual' discrimination, this Cambridge Element addresses the concept of 'translingual discrimination', which refers to inequality based on transnational migrants' specific linguistic and communicative repertoires that are (il)legitimized by the national order of things. Translingual discrimination adds intensity to transnational processes, with transnational migrants showing two main characteristics of exclusion - 'translingual name discrimination' and its associated elements such as 'name stigma' and 'name microaggression'; and 'translingual English discrimination' and its elements such as 'accentism', 'stereotyping' and 'hallucination'. The accumulation of these characteristics of translingual discrimination causes negative emotionality in its victims, including 'foreign language anxiety' and 'translingual inferiority complexes'. Consequently, transnational migrants adopt coping strategies such as 'CV whitening', 'renaming practices', 'purification', and 'ethnic evasion' while searching for translingual safe spaces. The Element concludes with the social and pedagogical implications of translingual discrimination in relation to transnational migrants.
Effective Field Theories
Authors: Meißner Ulf-G , Rusetsky Akaki
Published: November 2022

Effective field theories are a widely used tool in various branches of physics. This book provides a comprehensive discussion of the foundations and fundamentals of effective field theories of quantum chromodynamics (QCD) in the light quark sector with an emphasis on the study of flavour symmetries and their realizations. In this context, different types of effective field theories pertaining to various energy scales are considered and selected applications are devised. It also covers the formulation of effective field theories in a finite volume and its application in the analysis of lattice QCD data. Effective Field Theories is intended for graduate students and researchers in particle physics, hadron physics and nuclear physics. Exercises are included to help the reader deepen their understanding of the topics discussed throughout, with solutions available to lecturers.
Ruling the Country without Law: The Insoluble Dilemma of Transforming China into a Law-Governed Country
Authors: ZHANG Zhong
Published: November 2022

Despite more than 40 years’ legislation to build a ‘law-governed country’ and the Communist Party of China (CPC)'s repeated proclaiming to ‘govern the country according to law’, China still lacks legislation concerning a constitutional matter that is central to its governance, ie, the powers of the CPC to rule. No law specifies its powers, and the CPC's rule is not based on law. Why has such a crucial and apparent loophole not been filled? It is essentially because of the CPC's insistence on supremacy with unchallengeable authority in the governance of China. Specifying in law the Party's powers, and how they should be exercised, would subject its rule to law and set a legal limit on its powers, which is irreconcilable with its goals of maintaining supremacy and absolute authority. Hence, an insoluble dilemma can be observed: while the CPC leadership wants China to become a law-governed country to attain lasting order and stability, they have to rule the country extralegally to avoid legal challenges to the supremacy of their rule. This article not only sheds light on this inherent contradiction, but also offers insight into the nature of the CPC's practice to ‘govern the country according to law’.
Paying a Premium for “Green Steel”: Paying for an Illusion?
Authors: Johansson Per-Olov , Kriström Bengt
Published: November 2022

The iron and steel industry generates around 10 % of global greenhouse gas emissions. The bulk of the emissions originates from the iron ore reduction. In this reduction, coal is used as a reagent. Steelmakers could switch to hydrogen-based direct reduction using hydrogen instead of coal as a reagent to reduce iron ore to pig iron. This would eliminate the CO2 emissions from the equivalent process in a traditional blast furnace. However, the process requires massive amounts of electricity. This paper looks at the economics of such a switch to “green steel.” We assess a marginal increase in the production of a hypothetical green steelmaker. We also undertake an investment appraisal of a green plant, based on an ongoing installation in Northern Sweden, but also briefly consider a possible/planned investment in the US. This appraisal is complemented by computing the survival function for the net present value in a systematic sensitivity analysis. It seems highly unlikely that a green steel plant can be socially profitable. If the green plant displaces conventional steel produced within the European Union’s cap-and-trade system for greenhouse gases, total emissions remain more or less unaffected; permits and emissions are simply reshuffled. Hence, if end-users of green steel pay a premium, they might pay for an illusion.
The Role of the Neurological Examination in Primary Care Referrals to Neurology
Authors: Reiter-Campeau Sandra , Moore Fraser
Published: November 2022

Low confidence with the neurological examination may contribute to primary care physicians’ discomfort with neurology and a low threshold to refer patients. We surveyed primary care physicians in Quebec about their last three referrals to neurology to evaluate what role the neurological examination played in their decision. Twenty-six physicians answered concerning 73 patient referrals. We found that primary care physicians use the neurological examination to reinforce their decision but rarely depend on the findings. Our results suggest that improving history-taking rather than examination skills may have more impact on neurology referrals, influencing quality of referral information above quantity of referrals.
Effects of kinematic and magnetic boundary conditions on the dynamics of convection-driven plane layer dynamos
Authors: Naskar Souvik , Pal Anikesh
Published: November 2022

Rapidly rotating convection-driven dynamos are investigated under different kinematic and magnetic boundary conditions using direct numerical simulations. At a fixed rotation rate, represented by the Ekman number$Ek=5\times 10^{-7}$, the thermal forcing is varied from$2$to$20$times its value at the onset of convection ($\mathcal {R}=Ra/Ra_c=2\unicode{x2013}20$, where$Ra$is the Rayleigh number), keeping the fluid properties constant ($Pr=Pr_m=1$, where$Pr$and$Pr_m$are the thermal and magnetic Prandtl numbers). The statistical behaviour of the dynamos, including the force balance, energetics, and heat transport, depends on the boundary conditions that dictate both the boundary layer and the interior dynamics. At a fixed thermal forcing ($\mathcal {R}=3$), the structure and strength of the magnetic field produced by the dynamos, especially near the walls, depend on both velocity and magnetic boundary conditions. Though the leading-order force balance in the bulk remains geostrophic, the Lorentz force becomes comparable to the Coriolis force inside the thermal boundary layer with no-slip, perfectly conducting conditions. In this case, a term signifying the work done by the Lorentz force in the turbulent kinetic energy (TKE) equation is found to have some components that extract energy from the velocity field to produce the magnetic field, while some other components extract energy from the magnetic field to produce TKE. However, with no-slip, pseudo-vacuum conditions, all the components of the work done by the Lorentz force perform unidirectional energy transfer to produce magnetic energy from the kinetic energy of the fluid to sustain dynamo action. We find heat transfer enhancement in the rotating dynamo convection, as compared with non-magnetic rotating convection, with the peak enhancement lying in the range$\mathcal {R}=3\unicode{x2013}4$. For free-slip conditions, in the absence of an Ekman layer, the dynamo action may alter the heat transport significantly by suppressing the formation of large-scale vortices. However, the highest heat transfer enhancement is found at$\mathcal {R}=3$with no-slip, perfectly conducting walls, which can be attributed to a local magnetorelaxation of the rotational constraint due to enhanced Lorentz force inside the thermal boundary layer.
Prison Disproportion in Democracies: A Comparative Analysis
Authors: Anderson J. P.
Published: November 2022

This article demonstrates a method to measure the extent and variation of ethnoracial disproportion in world prison populations. Using a novel data set covering eighteen democracies for the year 2016, this method shows that conspicuous ethnoracial disproportion in prisons is pervasive in democracies for which data is available. Socioeconomically marginalized ethnic and racial groups are overrepresented in the prisons of every case. Further, this pattern extends to countries known for penal progressivism, which otherwise are regarded as models of fair and rational criminal justice implementation. Correlation between prison disproportion and national socioeconomic and criminal justice characteristics suggests the complexity of the issue. A selection of single-case analyses drawn from the sample describe prison disproportion emerging under significantly varied national conditions. I discuss causal hypotheses for why ethnoracial disproportion would occur in such differing places.
Not “Civilized” Enough to Be Taxed: Indigeneity, Citizenship, and the 1919 Alaska School Tax
Authors: Zahnd Maximilien
Published: November 2022

In 1919, the Territory of Alaska enacted a tax to finance its school system, in which Native children could attend public schools alongside non-Native children only if they were “of mixed blood” and led “a civilized life.” As originally enacted, the scope of the tax included every man within a certain age bracket, meaning that all Native men would have been required to pay a tax designed to finance a racist and discriminatory policy. However, the Alaska governor and his attorney general quickly decided to narrow the scope of the tax to Natives who were either “civilized” settler colonial subjects or “uncivilized” workers in settler spaces. But what did this revised scope reflect? This article uses the history of the 1919 Alaska school tax to unpack the role of tax law in shaping subaltern political and sociocultural identities. It argues that the tax provided two of the territory’s most powerful men an opportunity to express and reinforce their ideological views on indigeneity. The tax also helped them advance settler colonialism, both by ensuring that segregated territorial schools would thrive and by crafting a legal instrument that allowed them to decide who was “civilized” enough to be a taxpayer.
Fourier multipliers for Hardy spaces on graded Lie groups
Authors: Hong Qing , Hu Guorong , Ruzhansky Michael
Published: November 2022

In this paper, we investigate the $H^{p}(G) \rightarrow L^{p}(G)$, $0< p \leq 1$, boundedness of multiplier operators defined via group Fourier transform on a graded Lie group $G$, where $H^{p}(G)$ is the Hardy space on $G$. Our main result extends those obtained in [Colloq. Math. 165 (2021), 1–30], where the $L^{1}(G)\rightarrow L^{1,\infty }(G)$ and $L^{p}(G) \rightarrow L^{p}(G)$, $1< p <\infty$, boundedness of such Fourier multiplier operators were proved.
Luminescence chronology of fluvial and aeolian deposits from the Emirate of Sharjah, UAE
Authors: Mueller Daniela , Raith Kira , Bretzke Knut , Fülling Alexander , Parker Adrian G. , Parton Ash , Preston Gareth W. , Jasim Sabah , Yousif Eisa , Preusser Frank
Published: November 2022

Quaternary environments on the Arabian Peninsula shifted between pronounced arid conditions and phases of increased rainfall, which had a profound impact on Earth surface processes. However, while aeolian sediment dynamics are reasonably well understood, there is a lack of knowledge with regard to variability in the fluvial systems. Presented here are the findings from several locations within wadi drainage systems to the west of the Hajar Mountains (United Arab Emirates). The performance of optically stimulated luminescence dating using a customized standardized growth curve approach is investigated, showing that this approach allows reliable determination of ages by reducing the machine time required. Three main periods of fluvial activity occurred at 160–135, 43–34, and ca. 20 ka. Additional ages fall into the latest Pleistocene and Late Holocene. None of the ages coincides with major wet periods in SE Arabia that have been identified in stalagmites and by the deposition of lake sediments. It is shown that fluvial activity was partly contemporaneous (within the given time resolution) with phases of aeolian deposition and was almost continuous, but likely sporadic, during the Middle to Late Pleistocene. This highlights the need for regionally defined paleoenvironmental records to fully understand the response of dryland systems to long-term climatic change.
Nematodes and trematodes associated with terrestrial gastropods in Nottingham, England
Authors: Andrus P. S. , Rae R. , Wade C. M.
Published: November 2022

A parasitological survey of terrestrial slugs and snails was conducted at popular dog walking locations across the city of Nottingham, with the intensions of finding gastropods infected with parasites of medical (or veterinary) importance such as lungworm (metastrongyloid nematodes) and trematodes. A total of 800 gastropods were collected from 16 sites over a 225 km2area. The extracted nematodes and trematodes were identified by molecular barcoding. Of the 800 gastropods collected, 227 were infected (172 had nematode infections, 37 had trematode infections and 18 had both nematode and trematode infections). Of the nematode infected gastropods genotyped, seven species were identified,Agfa flexilis,Angiostoma gandavense,Angiostoma margaretae,Cosmocerca longicauda,Phasmarhabditis hermaphrodita,Phasmarhabditis neopapillosaand an unknown Cosmocercidae species. Of the trematode infected gastropods genotyped, four species were identified,Brachylaima arcuate,Brachylaima fuscata,Brachylaima mesostomaand an unknown Plagiorchioidea species. No lungworm species were found within the city of Nottingham. To our knowledge, this study represents the first survey of gastropod-associated nematodes and trematodes in the East midlands of the United Kingdom.
Onset conspiracy in Upper Sorbian
Authors: RUBACH JERZY
Published: November 2022

This article has two goals: descriptive and theoretical. On the descriptive side, the article presents a grammar of gliding and epenthesis of Upper Sorbian. The descriptive goal is worthy because Upper Sorbian has a highly complex but regular and productive system of gliding and epenthesis. Upper Sorbian stands out from a typological point of view because it has ten [sic] different strategies to satisfy Onset.

On the theoretical side, the question is whether Optimality Theory that has been designed to solve conspiracies can deal with the complexities of Upper Sorbian. The answer is that it cannot unless it is modified to admit derivational levels. A point of interest is that level 1 in Upper Sorbian must be defined as the root level, not as the expected stem level that includes roots and affixes. Further, it is demonstrated that Itô and Mester’s CrispEdgeconstraint makes wrong predictions for Upper Sorbian, so a new constraint, Multi, is postulated. Also, the analysis bears on the issue of positional markednessversuspositional faithfulness and the question of whether Duke of York derivations should be admitted in phonology.
Overview of renicolid digeneans (Digenea, Renicolidae) from marine gulls of northern Holarctic with remarks on their species statuses, phylogeny and phylogeography
Authors: Galaktionov Kirill V. , Solovyeva Anna I. , Blakeslee April M. H. , Skírnisson Karl
Published: November 2022

Renicolid digeneans parasitize aquatic birds. Their intramolluscan stages develop in marine and brackish-water gastropods, while metacercariae develop in molluscs and fishes. The systematics of renicolids is poorly developed, their life cycles are mostly unknown, and the statuses of many species require revision. Here, we establish based on integrated morphological and molecular data that adult renicolids from gulls Larus argentatus and Larus schistisagus and sporocysts and cercariae of Cercaria parvicaudata from marine snails Littorina spp. are life-cycle stages of the same species. We name it Renicola parvicaudatus and synonymized with it Renicola roscovitus. An analysis of the cox1 gene of R. parvicaudatus from Europe, North America and North Asia demonstrates a low genetic divergence, suggesting that this species has formed quite recently (perhaps during last glacial maximum) and that interregional gene flow is high. In Littorina saxatilis and L. obtusata from the Barents Sea, molecular analysis has revealed intramolluscan stages of Cercaria littorinae saxatilis VIII, a cryptic species relative to R. parvicaudatus. In the molecular trees, Renicola keimahuri from L. schistisagus belongs to another clade than R. parvicaudatus. We show that the species of this clade have cercariae of Rhodometopa group and outline morphological and behavioural transformations leading from xiphidiocercariae to these larvae. Molecular analysis has revealed 3 main phylogenetic branches of renicolids, differing in structure of adults, type of cercariae and host range. Our results elucidate the patterns of host colonization and geographical expansion of renicolids and pave the way to the solution of some long-standing problems of their classification.
Reduced magnetic mismatch negativity: a shared deficit in psychosis and related risk
Authors: Valt Christian , Quarto Tiziana , Tavella Angelantonio , Romanelli Fabiola , Fazio Leonardo , Arcara Giorgio , Altamura Mario , Barrasso Giuseppe , Bellomo Antonello , Blasi Giuseppe , Brudaglio Flora , Carofiglio Angela , D'Ambrosio Enrico , Padalino Flavia Antida , Rampino Antonio , Saponaro Alessandro , Semisa Domenico , Suma Domenico , Pergola Giulio , Bertolino Alessandro
Published: November 2022

Background

Abnormal auditory processing of deviant stimuli, as reflected by mismatch negativity (MMN), is often reported in schizophrenia (SCZ). At present, it is still under debate whether this dysfunctional response is specific to the full-blown SCZ diagnosis or rather a marker of psychosis in general. The present study tested MMN in patients with SCZ, bipolar disorder (BD), first episode of psychosis (FEP), and in people at clinical high risk for psychosis (CHR).

Methods

Source-based MEG activity evoked during a passive auditory oddball task was recorded from 135 patients grouped according to diagnosis (SCZ, BD, FEP, and CHR) and 135 healthy controls also divided into four subgroups, age- and gender-matched with diagnostic subgroups. The magnetic MMN (mMMN) was analyzed as event-related field (ERF), Theta power, and Theta inter-trial phase coherence (ITPC).

Results

The clinical group as a whole showed reduced mMMN ERF amplitude, Theta power, and Theta ITPC, without any statistically significant interaction between diagnosis and mMMN reductions. The mMMN subgroup contrasts showed lower ERF amplitude in all the diagnostic subgroups. In the analysis of Theta frequency, SCZ showed significant power and ITPC reductions, while only indications of diminished ITPC were observed in CHR, but no significant decreases characterized BD and FEP.

Conclusions

Significant mMMN alterations in people experiencing psychosis, also for diagnoses other than SCZ, suggest that this neurophysiological response may be a feature shared across psychotic disorders. Additionally, reduced Theta ITPC may be associated with risk for psychosis.
Cost-containment long-term care policies for older people across the Organisation for Economic Co-operation and Development (OECD): a scoping review
Authors: Gori Cristiano , Luppi Matteo
Published: November 2022

In most Organisation for Economic Co-operation and Development (OECD) countries, the government has to manage tension between growth in the need for long-term care (LTC) services for older people and significant public budget constraints. Not surprisingly, therefore, cost-containment policies are of increasing relevance. Nevertheless, despite the flourishing interest in the comparative literature in reforms and the sustainability of LTC policies, a scoping review of these measures has so far not been produced. This article aims to contribute to filling this gap. We present a typology of LTC cost-containment policies across the OECD. Cost-containment policies cluster in two areas according to their focus: demand-side policies, which reduce the actual chances of receiving LTC services and/or make them more expensive for users; and supply-side ones, which modify the provision of services. Furthermore, an indirect outcome of the review is that it allows an overview of potential negative implications of these policies. These negative implications can be grouped in two macro spheres relating to a worsening of the care arrangements for beneficiaries and to increased demand for individual/family resources, in both economic and time and effort terms. In the light of the expected profound impacts of the COVID-19 outbreak on all social security sectors in the medium and long term, this article provides a valuable tool for both academic and policy-making debate. It allows an analytical comprehension of cost-containment strategies adopted in LTC sectors linking them with the related impacts on beneficiaries and their families.
Can we use existing guidance to support the development of robust real-world evidence for health technology assessment/payer decision-making?
Authors: Capkun Gorana , Corry Sorcha , Dowling Oonagh , Asad Zadeh Vosta Kolaei Fatemeh , Takyar Shweta , Furtado Cláudia , Jónsson Páll , Kleinermans Diane , Lambert Laurie , Schiel Anja , Facey Karen
Published: November 2022

Advances in the digitization of health systems and expedited regulatory approvals of innovative treatments have led to increased potential for the use of real-world data (RWD) to generate real-world evidence (RWE) to complement evidence from clinical trials. However, health technology assessment (HTA) bodies and payers have concerns about the ability to generate RWE of sufficient quality to be pivotal evidence of relative treatment effectiveness. Consequently, there is a growing need for HTA bodies and payers to develop guidance for the industry and other stakeholders about the use of RWD/RWE to support access, reimbursement, and pricing. We therefore sought to (i) understand barriers to the use of RWD/RWE by HTA bodies and payers; (ii) review potential solutions in the form of published guidance; and (iii) review findings with selected HTA/payer bodies. Four themes considered key to shaping the generation of robust RWE for HTA bodies and payers were identified as: (i) data (availability, governance, and quality); (ii) methodology (design and analytics); (iii) trust (transparency and reproducibility); and (iv) policy and partnerships. A range of guidance documents were found from trusted sources that could address these themes. These were discussed with HTA experts. This commentary summarizes the potential guidance solutions available to help resolve issues faced by HTA decision-makers in the adoption of RWD/RWE. It shows that there is alignment among stakeholders about the areas that need improvement in the development of RWE and that the key priority to move forward is better collaboration to make data usable for multiple purposes.
Considerations for transferability of health technology assessments: a scoping review of tools, methods, and practices
Authors: Heupink Lieke Fleur , Peacocke Elizabeth Fleur , Sæterdal Ingvil , Chola Lumbwe , Frønsdal Katrine
Published: November 2022

Health technology assessment (HTA) is commonly used to guide evidence-informed decisions to optimize resource use, prioritize policies, and support countries to achieve universal health coverage. Producing HTAs requires time, scientific expertise, and political commitment, but these are not available in all settings – especially in low- and middle-income countries (LMIC) where HTA processes may be less institutionalized. Transferring and adapting existing HTAs to local settings may offer a solution while reducing duplication efforts. This scoping review aims to provide an overview of tools, methods, approaches, and considerations which can aid HTA transfers. We systematically searched (from 2005 to 2020) six databases and, using predefined inclusion criteria, included twenty-two studies. Data extraction followed a structured process, while synthesis was more iterative. We identified a common approach for HTA transfers. It follows the de novo process of undertaking original HTAs, but with additional steps to assess relevance (applicability), quality, and transferability, as well as steps to adapt parameters where necessary. The EUnetHTA Adaptation Toolkit was the only tool that provided guidance for adapting multiple HTA domains. Other tools were specific to systematic reviews (n = 1) or economic evaluations (n = 12), where one provided guidance for systematic reviews of economic evaluations. Eight papers reported transferring an HTA, with only one transferring to an LMIC. Finally, we reported issues that may facilitate or hinder transferability. In conclusion, we identified fourteen transfer approaches in the form of guidance or checklists, but harmonized and pragmatic guidance for HTA transfers to suit settings with limited HTA capacity seems warranted.
The complexity epistemology and ontology in second language acquisition: A critical review
Authors: Han ZhaoHong , Kang Eun Young , Sok Sarah
Published: November 2022

Complex Dynamic Systems Theory (CDST), an instantiation in applied linguistics of complexity epistemology that transcends disciplinary boundaries, has gained much traction and momentum over the last decade, finding expressions in a fast-growing number of empirical second language developmental studies. However, the literature, while rapidly expanding, has displayed much confusion, notably oscillating between invoking CDST as a metatheory and as an object theory. Then, too, the metaphorical genesis of CDST—the metaphorical adoption of complexity epistemology from physical sciences—has seemed to invite miscellaneous interpretations, rendering CDST an ostensibly all-in-one conceptual prism. This article explores the epistemology of CDST, tracing its ontology and examining its role in second language developmental research. This enables a more nuanced understanding of CDST, while at once surfacing critical issues and directions for future research, as it moves toward a pluralistic approach to investigating CDST as a potentially unique lens on second language development.
Germination responses in Zephyranthes tubispatha seeds exposed to different thermal conditions and the role of antioxidant metabolism and several phytohormones in their control
Authors: Acosta María Cecilia , Manfreda Vilma Teresa , Alcaraz María Luciana , Alemano Sergio , Causin Humberto Fabio
Published: November 2022

Zephyranthes tubispatha is an ornamental species distributed along several countries of South America. Although it can be multiplied through bulbs or scales, seed germination is a simpler and more cost-effective process. Temperature plays a major role in the control of germination; however, its effect has been scarcely investigated in this species. In the present work, we characterized the germination responses of Z. tubispatha seeds to different temperatures and analyzed the role of key components of the antioxidant metabolism and phytohormones in their control. Seeds showed an optimal temperature range for germination between 14 and 20°C, with higher temperatures (HTs) being progressively inhibitory. While germination was almost nil above 28°C, it could be recovered after transferring the seeds to 20°C, suggesting that thermoinhibition was the underlying phenomenon. The duration of the HT incubation period affected both the time to germination onset and the germination rate at 20°C. Similarly, the activity of antioxidant enzymes, the production of reactive oxygen species in the embryo and the sensitivity to some germination promoters varied depending on the duration of the HT treatment. The addition of 20 μM fluridone was sufficient to recover germination dynamics as in the control treatment when given after a long-term incubation period (25 d) at HT. Ethephon supply was more effective than gibberellins to suppress thermoinhibition, suggesting that changes in the balance and/or sensitivity to ethylene and abscisic acid over time play an important role in the regulation of germination responses to thermal cues in this species.
‘To be had for a Pesthouse for the use of this parish’: plague pesthouses in early Stuart London, c. 1600–1650
Authors: Columbus Aaron
Published: November 2022

The use of the pesthouse in early modern England has received limited attention by scholars, in particular, how it was used in London. The study of the pesthouse tells us about the nature of parochial government in the capital, the early development of public health policies and the relationship between national and civic authorities and the suburban parishes, where plague was a long-term problem and intersected forcefully with poverty. This article explores how suburban parishes used the pesthouse in their repertoire of response to plague between c. 1600 and 1650, which is situated in the context of experiments with the pesthouse in England's provincial towns and cities. The article considers the development of the City of London's pesthouse in St Giles Cripplegate, its limited use by suburban parishes under the City's jurisdiction, and the establishment of a local pesthouse by some suburban parishes beyond the jurisdiction of the City.