bluuebunny/crossref_metadata_2025 huggingface dataset:
Methods of Political Influence of Weak Interests Using the Example of the Reform Process of the Bundesteilhabegesetz (Federal Participation Act)
Authors: Schultz Laura
Published: January 2023

People with disabilities and their associations should have the opportunity to participate in decision-making processes by following the principle of “nothing about us without us,” according to the UN Convention on the Rights of People with Disabilities. This slogan was pursued as part of the reform process of the Federal Participation Act (Bundesteilhabegesetz) in Germany. Interest groups of people with disabilities (also referred to as “weak interests” in reference to association research) were intensively involved in various stages of the process. This article is based on results of a dissertation project that involved the process tracing method of the reform process of this new law. This paper takes a closer look at the methods of political influence used by interest groups of people with disabilities. Which activities were particularly effective in the context of the process considered here? What can other interest groups learn from the reform process of the Federal Participation Act about the direct use of power resources and lobbying? The power resource approach adapted to weak interests provides a basis, as do various lobbying activities, for demonstrating different ways in which weak interests influence the reform process. As the paper will show, the mix of different lobbying activities helped to assert some of their demands.
Ultrafast protein response in the Pfr state of Cph1 phytochrome
Authors: Yang Yang , Stensitzki Till , Lang Christina , Hughes Jon , Mroginski Maria Andrea , Heyne Karsten
Published: January 2023

Photoisomerization is a fundamental process in several classes of photoreceptors. Phytochromes sense red and far-red light in their Pr and Pfr states, respectively. Upon light absorption, these states react via individual photoreactions to the other state. Cph1 phytochrome shows a photoisomerization of its phycocyanobilin (PCB) chromophore in the Pfr state with a time constant of 0.7 ps. The dynamics of the PCB chromophore has been described, but whether or not the apoprotein exhibits an ultrafast response too, is not known. Here, we compare the photoreaction of 13C/15N labeled apoprotein with unlabeled apoprotein to unravel ultrafast apoprotein dynamics in Cph1. In the spectral range from 1750 to 1620 cm−1 we assigned several signals due to ultrafast apoprotein dynamics. A bleaching signal at 1724 cm−1 is tentatively assigned to deprotonation of a carboxylic acid, probably Asp207, and signals around 1670 cm−1 are assigned to amide I vibrations of the capping helix close to the chromophore. These signals remain after photoisomerization. The apoprotein dynamics appear upon photoexcitation or concomitant with chromophore isomerization. Thus, apoprotein dynamics occur prior to and after photoisomerization on an ultrafast time-scale. We discuss the origin of the ultrafast apoprotein response with the ‘Coulomb hammer’ mechanism, i.e. an impulsive change of electric field and Coulombic force around the chromophore upon excitation.

Graphical abstract
An experimental and numerical study of turbulent oscillatory flow over an irregular rough wall
Authors: Dunbar Danny , van der A Dominic A. , Scandura Pietro , O'Donoghue Tom
Published: January 2023

The hydrodynamics of turbulent oscillatory flow over a gravel-based irregular rough wall is investigated using laser-Doppler anemometry measurements of velocities in a large oscillatory flow tunnel and direct numerical simulation (DNS) of the Navier–Stokes equations. The same periodic irregular roughness was used for both experiments and DNS. Four flow shapes are investigated: sinusoidal, skewed, asymmetric and combined skewed–asymmetric. The experiments were conducted for target Reynolds numbers (based on the Stokes length and standard deviation of free-stream velocity) of$R_{\delta,\sigma }=800$and$R_{\delta,\sigma }=1549$; DNS was conducted for flows with target$R_{\delta,\sigma }=800$. Boundary layer thickness, bottom phase lead and friction factor are in good agreement with previous studies. For the first time, evidence of Prandtl's secondary flows of the second kind in oscillatory flow is presented. Turbulence structure is visualised using isosurfaces of$\lambda _{2}$(Jeong & HussainJ. Fluid Mech., vol. 285, 1995, pp. 69–94), revealing densely packed structures that grow stronger and weaker in correspondence with the free-stream velocity. Reynolds and dispersive stresses peak just below the highest roughness crest, with dispersive stress vanishing a short distance above the roughness. Bursts of turbulence kinetic energy and wake kinetic energy are generated each flow half-cycle, with variable behaviour depending on flow shape. Non-Gaussian turbulence statistics are observed that originate near the wall, becoming increasingly non-Gaussian far from the wall. Probability density functions of turbulence statistics can be closely approximated by a fourth-order Gram–Charlier distribution at most phases and elevations, though when statistics deviate more strongly from Gaussian, streamwise and wall-normal (spanwise) statistics are better described by a Pearson type IV (VII) distribution.
Permeability sets the linear path instability of buoyancy-driven disks
Authors: Vagnoli Giovanni , Zampogna G.A. , Camarri S. , Gallaire F. , Ledda P.G.
Published: January 2023

The prediction of trajectories of buoyancy-driven objects immersed in a viscous fluid is a key problem in fluid dynamics. Simple-shaped objects, such as disks, present a great variety of trajectories, ranging from zig-zag to tumbling and chaotic motions. Yet, similar studies are lacking when the object is permeable. We perform a linear stability analysis of the steady vertical path of a thin permeable disk, whose flow through the microstructure is modelled via a stress-jump model based on homogenization theory. The relative velocity of the flow associated with the vertical steady path presents a recirculation region detached from the body, which shrinks and eventually disappears as the disk becomes more permeable. In analogy with the solid disk, one non-oscillatory and several oscillatory modes are identified and found to destabilize the fluid–solid coupled system away from its straight trajectory. Permeability progressively filters out the wake dynamics in the instability of the steady vertical path. Modes dominated by wake oscillations are first stabilized, followed by those characterized by weaker, or absent, wake oscillations, in which the wake is typically a tilting induced by the disk inclined trajectory. For sufficiently large permeabilities, the disk first undergoes a non-oscillatory divergence instability, which is expected to lead to a steady oblique path with a constant disk inclination, in the nonlinear regime. A further permeability increase reduces the unstable range of all modes until quenching of all linear instabilities.
Use of portable air purifiers to reduce aerosols in hospital settings and cut down the clinical backlog
Authors: Salmonsmith Jacob , Ducci Andrea , Balachandran Ramanarayanan , Guo Liwei , Torii Ryo , Houlihan Catherine , Epstein Ruth , Rubin John , Tiwari Manish K. , Lovat Laurence B.
Published: January 2023

SARS-CoV-2 has severely affected capacity in the National Health Service (NHS), and waiting lists are markedly increasing due to downtime of up to 50 min between patient consultations/procedures, to reduce the risk of infection. Ventilation accelerates this air cleaning, but retroactively installing built-in mechanical ventilation is often cost-prohibitive. We investigated the effect of using portable air cleaners (PAC), a low-energy and low-cost alternative, to reduce the concentration of aerosols in typical patient consultation/procedure environments. The experimental setup consisted of an aerosol generator, which mimicked the subject affected by SARS-CoV-19, and an aerosol detector, representing a subject who could potentially contract SARS-CoV-19. Experiments of aerosol dispersion and clearing were undertaken in situ in a variety of rooms with two different types of PAC in various combinations and positions. Correct use of PAC can reduce the clearance half-life of aerosols by 82% compared to the same indoor-environment without any ventilation, and at a broadly equivalent rate to built-in mechanical ventilation. In addition, the highest level of aerosol concentration measured when using PAC remains at least 46% lower than that when no mitigation is used, even if the PAC's operation is impeded due to placement under a table. The use of PAC leads to significant reductions in the level of aerosol concentration, associated with transmission of droplet-based airborne diseases. This could enable NHS departments to reduce the downtime between consultations/procedures
Subclinical myocardial assessment after BNT162b2 messenger RNA COVID-19 vaccination in adolescents with chronic heart disease: a speckle-tracking echocardiography study
Authors: Başkan Serra , Özer Pelin Karaca , Keskin Gülperi Yağar , Gövdeli Elif Ayduk , Ömeroğlu Rukiye Eker
Published: January 2023

Purpose:

Case reports of the development of perimyocarditis in adolescents and young adults after BNT162b2 messenger RNA (mRNA) COVID-19 vaccination have raised concerns about the cardiac side effects of the vaccine. The aim of the study was to evaluate clinical follow-up and subclinical myocardial function after mRNA COVID-19 vaccine in adolescents with chronic heart disease.

Methods:

Forty-one adolescents aged 12–18 who were followed up at paediatric cardiology clinic between December 2021 and May 2022, and who had received two doses of the Pfizer-BioNTech COVID-19 mRNA vaccine were included in the study. The patients were evaluated five times in total – before the vaccination, one week after receiving the first dose, one month after receiving the first dose, one week after receiving the second dose, and one month after receiving the second dose. Cardiac assessment for all patients included an electrocardiogram, transthoracic echocardiography, and two-dimensional speckle-tracking strain echocardiography for left ventricular subclinical myocardial function.

Results:

The mean age of the adolescents was 16.2 ± 1.5 years, and 56% (n = 23) were male. There was no statistically significant difference in patients' echocardiographic measurements including left ventricular global longitudinal strain and electrocardiogram parameters including PR, QRS, and QTc intervals through the follow-up. Seven patients reported cardiac complaints at post-vaccination follow-up visits, but laboratory and echocardiographic evidence of cardiac involvement was not observed.

Conclusions:

Based on the results of our study, the mRNA COVID-19 vaccine did not cause impairment in subclinical myocardial function assessed by speckle-tracking echocardiography in adolescents with chronic heart disease.
Myths About the Physical Sciences and Their Implications
for Teaching Political Science
Authors: Hill Kim Quaile
Published: January 2023

This paper describes misconceptions about the physical sciences that
are widely held by college students and that pose notable hurdles
for appreciating the social sciences as legitimate scientific
enterprises. My purpose here is pedagogical, too. In particular, I
respond to the persuasive, specific argument in prior scholarship
that students must overcome various negative or unconstructive
stereotypes about the physical sciences to achieve scientific
literacy.
Where is Political Science Going?
Authors: Sartori Giovanni
Published: January 2023

Political science, as we currently understand the label, was born, in Western Europe, in the early Fifties. One may say that it was “reborn”; but that would be inaccurate, for in the nineteenth century and until World War Two the label indicated a captive discipline largely dominated by juridical or historical approaches (as in the case, e.g., of Gaetano Mosca). So political science had a new start and became a field of inquiry in its own right about half a century ago. I was, at the time, one of its founders (with Stein Rokkan, Juan Linz, Mattei Dogan, Hans Daalder, Erik Allardt, S. N. Eisenstadt, and others. See: Comparative European Politics: The Story of a Profession, edited by H. Daalder, 1997). I am thus one of the witnesses of what the “young turks” of the time had in mind, of how we conceived and promoted political science. I am now an “ancient sage” and it now pleases me to reflect, some fifty years later, on where political science has gone and on whether it has taken the right course, the course that I had wished for and expected. Thus to ask today, in the middle of Mitteleuropa, where political science has been heading is also to ask whether the new beginnings of the discipline in Eastern Europe should or should not follow the path entered by our “big brother,” I mean, by American-type political science. I too have been somewhat swallowed by our big brother (to be sure, a benevolent and well meaning one) in the sense that I have been teaching in the United States for some thirty years. Let me add that I have largely benefited from my American exposure. Yet I have always resisted and still resist the American influence. And I take this occasion to say why I am unhappy about the American molding of present day political science.
APSA Teaching and Learning Conference: A Summary of Four
Tracks
Authors: Zook Nathan , Gitelson Alan R.
Published: January 2023

Service-learning and civic education have become popular pedagogical
themes as higher education attempts to embody diversity and
innovation in our teaching models. This trend, however, has resulted
in disagreement over the means by which service-learning and the
civic education theme should be incorporated into the classroom.
Some educators have sought to jump on the bandwagon without really
attempting to learn exactly what these tools entail, resulting in a
diffusion of their effectiveness.
Gesture and Texture in the Electroacoustic Improvised Music of Jin Sangtae, Hong Chulki and Tetuzi Akiyama
Authors: Hyvärinen Lauri
Published: January 2023

This article will examine the music of two improvisation scenes – Seoul’s ‘Dotolim’ and Tokyo’s onkyô – with a particular focus on their use of gesture and texture. The article centres on an analysis of a trio performance by Jin Sangtae, Hong Chulki and Tetuzi Akiyama, which effectively brings these two musical communities together in a collaborative performance. This analysis demonstrates that focusing on gesture and texture can help in perceiving essential aspects of an improvised performance, including understanding strategic modes of listening and interplay, musical structural developments (both micro and macro) as well as identifying applied roles of instrumental technique and approach.
Changing Water Chemistry in One Thousand Norwegian Lakes During Three Decades of Cleaner Air and Climate Change
Authors: de Wit Heleen A. , Garmo Øyvind A. , Jackson‐Blake Leah A. , Clayer François , Vogt Rolf D. , Austnes Kari , Kaste Øyvind , Gundersen Cathrine Brecke , Guerrerro Jose Luis , Hindar Atle
Published: January 2023

We present long‐term changes in Norwegian lake water quality across regional gradients in atmospheric pollution, air temperature, hydrology, and vegetation using (a) a national representative lake survey carried out in 1995 and 2019 (ThousandLakes), and (b) an annual lake survey from acid‐sensitive catchments (78 lakes, TrendLakes) from 1990 to 2020. Our analysis encompasses all major chemical constituents, for example, anions and cations, dissolved organic matter (DOM), nutrients, iron (Fe), and silicate (SiO2). During these decades, environmental changes included declines in sulfur (S) and nitrogen (N) deposition, climate warming, and increase in forest biomass. Strong chemical recovery from acidification is found, attributed to large reductions in atmospheric deposition, moderated by catchment processing from land use and climate change. Browning counteracted chemical recovery in some regions, while Ca increased unexpectedly. We suggest that increased weathering, from enhanced terrestrial productivity, is an important driver of increased Ca—substantiated by widespread, substantial increases in SiO2. Light‐ and nutrient‐limitation has become more prevalent, indicated by higher DOM, lower nitrate (NO3), and lower NO3to total phosphorous ratios. Declines in lake NO3 occurred independently of N deposition, suggesting increased catchment N retention, possibly from increased terrestrial productivity. We conclude that decreased air pollution continues to be a dominant driver of long‐term trends in lake chemistry, but climate‐induced increase in terrestrial weathering processes, governed by increased biomass, is likely to have an increasing impact on future lake acidity, nutrient, and light status, that may cascade along the aquatic continuum from rivers to the coast.
Examining Hurricane Ida's Impact on Mental Health: Results From a Quasi‐Experimental Analysis
Authors: Wertis Luke , Runkle Jennifer D. , Sugg Margaret M. , Singh Devyani
Published: January 2023

Limited research has evaluated the mental health effects during compounding disasters (e.g., a hurricane occurring during a pandemic), and few studies have examined post‐disaster mental health with alternative data sources like crisis text lines. This study examined changes in crisis help‐seeking for individuals in Louisiana, USA, before and after Hurricane Ida (2021), a storm that co‐occurred during the COVID‐19 pandemic. An interrupted time series analysis and difference‐in‐difference analysis for single and multiple group comparisons were used to examine pre‐and post‐changes in crisis text volume (i.e., any crisis text, substance use, thoughts of suicide, stress/anxiety, and bereavement) among help‐seeking individuals in communities that received US Federal Emergency Management Agency individual and public assistance following a presidential disaster declaration. Results showed a significant increase in crisis texts for any reason, thoughts of suicide, stress/anxiety, and bereavement in the four‐week, three‐month, and four‐month post‐impact period. Findings highlight the need for more mental health support for residents directly impacted by disasters like Hurricane Ida.
Pleistocene Accelerated Exhumation Within the Sumatran Fault: Implications for Late Cenozoic Evolution of Sumatra (Indonesia)
Authors: Wang Yang , Gao Yan , Morley Chris K. , Seagren Erin G. , Qian Xin , Rimando Jeremy M. , Zhang Peizhen , Wang Yuejun
Published: January 2023

The 1,900‐km‐long Sumatran fault plays an important role in accommodating oblique plate motion between the Indo‐Australian and Sunda plates. Although fault geometry, kinematics, and seismic activity are well‐studied, the onset of dextral motion on the Sumatran fault and uplift of adjacent Barisan Mountains is unclear; this hinders an understanding of the late Cenozoic evolution of Sumatra and the forearc region. In this study, we use low‐temperature thermochronology to measure cooling histories of rocks within and outside of the Sumatran fault. An accelerated exhumation within the fault zone began at ∼2 Ma. The Barisan Mountains may have experienced uplift and associated river incision in the late Miocene to Pliocene. The fault systems in the forearc region were inferred to be kinematically linked to the Andaman Sea and Sunda Strait and accommodated early relative plate convergence, then relocated the strike‐slip component of deformation to the Sumatran fault at ∼2 Ma.
The Role of Mesoscale Cloud Morphology in the Shortwave Cloud Feedback
Authors: McCoy Isabel L. , McCoy Daniel T. , Wood Robert , Zuidema Paquita , Bender Frida A.‐M.
Published: January 2023

A supervised neural network algorithm is used to categorize near‐global satellite retrievals into three mesoscale cellular convective (MCC) cloud morphology patterns. At constant cloud amount, morphology patterns differ in brightness associated with the amount of optically thin cloud features. Environmentally driven transitions from closed MCC to other morphology patterns, typically accompanied by more optically thin cloud features, are used as a framework to quantify the morphology contribution to the optical depth component of the shortwave cloud feedback. A marine heat wave is used as an out‐of‐sample test of closed MCC occurrence predictions. Morphology shifts in optical depth between 65°S and 65°N under projected environmental changes (i.e., from an abrupt quadrupling of CO2) assuming constant cloud cover contributes between 0.04 and 0.07 W m−2 K−1 (aggregate of 0.06) to the global mean cloud feedback.
The Climate Control of Soil Organic Carbon Dynamics Inferred From Speleothem Radiocarbon Ages
Authors: Xue Gang , Cai Yanjun , Cheng Peng , Lechleitner Franziska A. , Zhang Haiwei , Zheng Yanhong , Wei Yingying , Huang Shouyi , Yang Ling , Cheng Xing , Lu Yanbin , Zhou Jie , Ma Le , Cheng Hai , Edwards R. Lawrence
Published: January 2023

The complexity of processes affecting soil organic carbon (SOC) turnover on spatio‐temporal scales often hinders the extrapolation of results from specific sites to larger scales. This study presents Holocene speleothem U‐Th ages paired with 14C ages of carbonate and dissolved organic carbon (DOC) through three caves located on a north‐south transect through China. The deviations of speleothem 14CDOC ages from the U‐Th ages show clearly spatial variability, and they are positively correlated with mean ages of modern SOC and soil turnover time, suggesting that deviations can be used to infer the SOC turnover. We further demonstrate that slow SOC turnover (large deviation) was associated with weak monsoon (low temperature/less precipitation) on temporal scales. Our findings reveal that climate dominates the speleothem 14CDOC ages and SOC turnover. As global warming likely will intensify, the accelerated turnover of SOC, particularly at higher latitude areas, may partially offset the existing soil carbon stock.
Revisiting the Mechanisms of ENSO Response to Tropical Volcanic Eruptions
Authors: Pausata Francesco S. R. , Zhao Yang , Zanchettin Davide , Caballero Rodrigo , Battisti David S.
Published: January 2023

Stratospheric volcanic aerosol can have major impacts on global climate. Despite a consensus among studies on an El Niño‐like response in the first or second post‐eruption year, the mechanisms that trigger a change in the state of El Niño‐Southern Oscillation (ENSO) following volcanic eruptions are still debated. Here, we shed light on the processes that govern the ENSO response to tropical volcanic eruptions through a series of sensitivity experiments with an Earth System Model where a uniform stratospheric volcanic aerosol loading is imposed over different parts of the tropics. Three tropical mechanisms are tested: the “ocean dynamical thermostat” (ODT); the cooling of the Maritime Continent; and the cooling of tropical northern Africa (NAFR). We find that the NAFR mechanism plays the largest role, while the ODT mechanism is absent in our simulations as La Niña‐like rather than El‐Niño‐like conditions develop following a uniform radiative forcing over the equatorial Pacific.
Rapid Enhancements of Relativistic Electrons in the Earth's Outer Radiation Belt Caused by the Intense Substorms: A Statistical Study
Authors: Tang ChaoLing , Yang Chang , Chen JingRun , Wang Xu , Ni BinBin , Su ZhengPeng , Zhang JiChun
Published: January 2023

Using the data from Van Allen Probe A and B, we investigate rapid enhancements of relativistic electrons in the Earth's outer radiation belt caused by the intense substorms (AEmax > ∼900 nT) for 29 events from January 2013 to April 2015. These intense substorms may occur during the storm main phase or recovery phase. Based on the different substorm evolution characteristics, the intense substorms are divided into non‐continuous intense substorm activities and continuous intense substorm activities. In this study, we set a criterion for rapid enhancements when the electron phase space densities for μ = 1,096, 2,290, and 3,311 MeV/G increased by more than two times in 9 hr. In the time interval of 9 hr, the local acceleration by chorus waves is the dominant process for accelerating the seed populations (hundred kiloelectron volts) up to MeV energies. Our statistical results show that enhanced chorus waves and seed electrons during the intense substorms are observed in the outer radiation belt. Continuous intense substorm activities can more rapidly (<9 hr) and efficiently accelerate relativistic electrons in the outer radiation belt than non‐continuous intense substorm activities. During the intense substorms, the electric field acceleration could contribute to rapid enhancements of relativistic electrons in the outer radiation belt. Our statistical study suggests that the intense substorms during geomagnetic storms have a significant effect on the rapid variations of relativistic electron dynamics.
Global Application of the Atmospheric River Scale
Authors: Guan Bin , Waliser Duane E. , Ralph F. Martin
Published: January 2023

Atmospheric rivers (ARs) are narrow, elongated, transient corridors of enhanced water vapor transport that play important roles in the global water cycle. Increasing scientific and societal interests in ARs prompted the introduction of an AR scale (ranks 1–5, from weak to strong) initially focused on western North America. Aided by a global AR detection algorithm, the current study explores the insights the AR scale can help provide from a global perspective. It is found that AR event count is inversely related to AR rank and peaks in midlatitude oceans. Out of all precipitation occurrences, ARs account for an increasing fraction as the precipitation intensity considered increases. Over the oceans, this fraction is composed of comparable contributions from the five AR ranks, but the contribution of AR 5 is much smaller over land. Higher‐ranked ARs tend to initiate at lower latitudes, terminate at higher latitudes, but follow a less sloped track due to longer zonal displacement. Sensitivity analysis indicates that if ARs are defined using a sole IVT threshold of 250 kg m−1 s−1 globally but with the tropics excluded, the spatiotemporal patterns of key AR event characteristics are largely similar to those described above, except AR events are more frequent by a factor of ∼1.5–2 depending on the AR rank. The results demonstrate the potential of the AR scale in helping evaluate and communicate ARs' influences globally, where the uniform scaling facilitates intercomparisons across different regions and the perception of impacts can be adjusted according to local climatology.
Understanding the Seasonality, Trends, and Controlling Factors of Indian Ocean Acidification Over Distinctive Bio‐Provinces
Authors: Madkaiker Kunal , Valsala Vinu , Sreeush M. G. , Mallissery Anju , Chakraborty Kunal , Deshpande Aditi
Published: January 2023

The Indian Ocean (IO) is witnessing acidification as a direct consequence of the continuous rising of atmospheric CO2 concentration and indirectly due to rapid ocean warming, which disrupts the pH of the surface waters. This study investigates the pH seasonality and trends over various bio‐provinces of the IO and regionally assesses the contribution of each of its controlling factors. Simulations from a global and a regional ocean model coupled with biogeochemical modules were validated with pH measurements over the basin and used to discern the regional response of pH seasonality (1990–2010) and trend (1961–2010) to changes in Sea Surface Temperature (SST), Dissolved Inorganic Carbon (DIC), Total Alkalinity (ALK), and Salinity (S). DIC and SST are significant contributors to the seasonal variability of pH in almost all bio‐provinces. Total acidification in the IO basin was 0.0675 units from 1961 to 2010, with 69.3% contribution from DIC followed by 13.8% contribution from SST. For most of the bio‐provinces, DIC remains a dominant contributor to changing trends in pH except for the Northern Bay of Bengal and Around India (NBoB‐AI) region, wherein the pH trend is dominated by ALK (55.6%) and SST (16.8%). Interdependence of SST and S over ALK is significant in modifying the carbonate chemistry and biogeochemical dynamics of NBoB‐AI and a part of tropical, subtropical IO bio‐provinces. A strong correlation between SST and pH trends infers an increasing risk of acidification in the bio‐provinces with rising SST and points out the need for sustained monitoring of IO pH in such hotspots.
Presence of Access Roads Results in Reduced Growing Season Carbon Uptake in Adjacent Boreal Peatlands
Authors: Saraswati Saraswati , Xu Bin , Strack Maria
Published: January 2023

We conducted a 2‐year study to examine the impacts of resource access roads on carbon (C) exchange in two forested boreal peatlands (a bog and a fen). Along six transects (perpendicular to the road), at 2, 6, and 20 m from the edge of the road on both sides of the road (RI areas), we measured understory CO2 fluxes bi‐weekly from May to August 2016 and 2017 and compared this to measurements at reference areas at least 50 m from the road. Furthermore, we estimated aboveground biomass and net primary productivity of overstory shrubs and trees and combined that with understory fluxes to estimate annual net ecosystem carbon balance, and road‐induced C emissions. Overall, at the bog, the RI areas were sources of C in both 2016 (89.9 g C m−2 y−1) and 2017 (108.9 g C m−2 y−1) while reference areas were sinks. However, at the fen, both RI areas (−744.7, −310.9 g C m−2 y−1 in 2016 and 2017, respectively) and reference areas were sinks of C. Averaged across both peatlands, the estimated road‐induced C losses were ∼7.97 and 7.40 Mg C for each km of the road in 2016 and 2017, respectively. However, areas connected by culverts showed lower road‐associated impact on C emissions. Therefore, we suggest that industries and infrastructure developers align the road parallel to the local water flow direction, when possible, consider the hydrogeological setting during road design to reduce hydrologic impacts, and increase hydrological flows between up‐ and downstream by adequate culverts.
High‐Resolution Sporadic E Layer Observation Based on Ionosonde Using a Cross‐Spectrum Analysis Imaging Technique
Authors: Liu Tongxin , Yang Guobin , Jiang Chunhua
Published: January 2023

The appearance of the sporadic E (Es) layer is an occasional phenomenon in the ionosphere. Limited by range resolution, it is difficult to observe the fine structures and internal evolution processes using existing ionosonde detection techniques. In this study, by analyzing the cross‐spectrum of the echo and the modulation sequence of the transmitted signal, the coherence between frequency components in the signal bandwidth is utilized. Using the Capon spectrum estimation method in the range dimension, the range resolution and use efficiency of the ionosonde are improved. This method does not rely on the joint processing of multifrequency detection data, unlike the frequency domain interferometry technique, maintaining the resulting time resolution. Using this imaging method, observations of the Es layer show that multiple peaks within an intrinsic range bin (3.84 km) can be resolved at a range that is 10‐fold higher (384 m); the multilayer phenomenon inside the Es layer can be clearly imaged in a continuous echo. Semishading between the layers is present. In some cases, the mode of the echo traces can also be directly identified through high‐resolution imaging. Concurrently, observations show that dramatic short‐term evolution processes on the order of seconds inside the Es layer can be captured.
Validation testing of five home blood pressure monitoring devices for the upper arm according to the ISO 81060-2:2018/AMD 1:2020 protocol
Authors: Peprah Yaw Amofa , Lee Ji Young , Persell Stephen D.
Published: January 2023

The accuracy of Omron 10 Series BP7450 (HEM-7342T-Z), Omron Platinum BP5450 (HEM-7343T-Z), Walmart Equate Premium 8000 Series UA-8000WM, Walgreens Premium 15+ WGNBPA-960BT, and CVS Series 800 BP3MW1-4YCVS were assessed in an adult general population compared to a mercury sphygmomanometer standard according to the ISO 81060-2:2018/AMD 1:2020 validation procedure. Omron selected the monitors and included three non-Omron monitors because they were from large retail vendors in the United States and these monitors did not have accessible results from validation testing. The BP7450, N = 85, passed both criteria for the standard. Mean (SD) differences in paired SBP and DBP determinations between the test device and reference were 0.5 (7.7) and 2.5 (6.8) mm Hg. The BP5450, N = 86, passed both criteria. Mean (SD) differences in paired SBP and DBP determinations were 1.9 (7.0) and 3.6 (6.4) mm Hg. The UA-8000WM, N = 85, did not meet the first criterion for the standard. Mean (SD) differences in paired SBP and DBP determinations were 2.5 (8.0) and 5.1 (6.4) mm Hg. The WGNBPA-240BT, N = 85, did not meet the first criterion for the standard. Mean (SD) differences in paired SBP and DBP determinations were 7.9 (8.5) and 5.5 (6.7) mm Hg. The BP3MW1-4YCVS, N = 85, did not meet the first criterion for the standard. Mean (SD) differences in paired SBP and DBP determinations were 5.8 (8.7) and 3.1 (5.6) mm Hg. These findings emphasize the importance of verifying the validation status of home blood pressure monitors before use by consumers.
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
Authors: Osete Jordi Requena , Akkouh Ibrahim A. , Ievglevskyi Oleksandr , Vandenberghe Matthieu , de Assis Denis Reis , Ueland Thor , Kondratskaya Elena , Holen Børge , Szabo Attila , Hughes Timothy , Smeland Olav B. , Steen Vidar Martin , Andreassen Ole A. , Djurovic Srdjan
Published: January 2023

Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a powerful tool for modeling BD-related disease mechanisms. We studied the effects of 1 mM Li treatment for 1 month in iPSC-derived human cortical spheroids (hCS) from 10 healthy controls (CTRL) and 11 BD patients (6 Li-responders, Li-R, and 5 Li non-treated, Li-N). At day 180 of differentiation, BD hCS showed smaller size, reduced proportion of neurons, decreased neuronal excitability and reduced neural network activity compared to CTRL hCS. Li rescued excitability of BD hCS neurons by exerting an opposite effect in the two diagnostic groups, increasing excitability in BD hCS and decreasing it in CTRL hCS. We identified 132 Li-associated differentially expressed genes (DEGs), which were overrepresented in sodium ion homeostasis and kidney-related pathways. Moreover, Li regulated secretion of pro-inflammatory cytokines and increased mitochondrial reserve capacity in BD hCS. Through long-term Li treatment of a human 3D brain model, this study partly elucidates the functional and transcriptional mechanisms underlying the clinical effects of Li, such as rescue of neuronal excitability and neuroprotection. Our results also underscore the substantial influence of treatment duration in Li studies. Lastly, this study illustrates the potential of patient iPSC-derived 3D brain models for precision medicine in psychiatry.
Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions
Authors: Jayachandran Priya , Battaglin Francesca , Strelez Carly , Lenz Annika , Algaze Sandra , Soni Shivani , Lo Jae Ho , Yang Yan , Millstein Joshua , Zhang Wu , Shih Jean C. , Lu Janice , Mumenthaler Shannon M. , Spicer Darcy , Neman Josh , Roussos Torres Evanthia T. , Lenz Heinz-Josef
Published: January 2023

Exploring the relationship between various neurotransmitters and breast cancer cell growth has revealed their likely centrality to improving breast cancer treatment. Neurotransmitters play a key role in breast cancer biology through their effects on the cell cycle, epithelial mesenchymal transition, angiogenesis, inflammation, the tumor microenvironment and other pathways. Neurotransmitters and their receptors are vital to the initiation, progression and drug resistance of cancer and progress in our biological understanding may point the way to lower-cost and lower-risk antitumor therapeutic strategies. This review discusses multiple neurotransmitters in the context of breast cancer. It also discusses risk factors, repurposing of pharmaceuticals impacting neurotransmitter pathways, and the opportunity for better integrated models that encompass exercise, the intestinal microbiome, and other non-pharmacologic considerations. Neurotransmitters’ role in breast cancer should no longer be ignored; it may appear to complicate the molecular picture but the ubiquity of neurotransmitters and their wide-ranging impacts provide an organizing framework upon which further understanding and progress against breast cancer can be based.
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
Authors: Koerner Lioba , Schmiel Marcel , Yang Tsun-Po , Peifer Martin , Buettner Reinhard , Pasparakis Manolis
Published: January 2023

Small cell lung cancer (SCLC) is an aggressive type of lung cancer driven by combined loss of the tumor suppressors RB1 and TP53. SCLC is highly metastatic and despite good initial response to chemotherapy patients usually relapse, resulting in poor survival. Therefore, better understanding of the mechanisms driving SCLC pathogenesis is required to identify new therapeutic targets. Here we identified a critical role of the IKK/NF-κB signaling pathway in SCLC development. Using a relevant mouse model of SCLC, we found that ablation of NEMO/IKKγ, the regulatory subunit of the IKK complex that is essential for activation of canonical NF-κB signaling, strongly delayed the onset and growth of SCLC resulting in considerably prolonged survival. In addition, ablation of the main NF-κB family member p65/RelA also delayed the onset and growth of SCLC and prolonged survival, albeit to a lesser extent than NEMO. Interestingly, constitutive activation of IKK/NF-κB signaling within the tumor cells did not exacerbate the pathogenesis of SCLC, suggesting that endogenous NF-κB levels are sufficient to fully support tumor development. Moreover, TNFR1 deficiency did not affect the development of SCLC, showing that TNF signaling does not play an important role in this tumor type. Taken together, our results revealed that IKK/NF-κB signaling plays an important role in promoting SCLC, identifying the IKK/NF-κB pathway as a promising therapeutic target.
Characterization of oscillation modes in levitated droplets using image and non-image based techniques
Authors: Brosius Nevin , Livesay Jason , Karpinski Zachary , Singiser Robert , SanSoucie Michael , Phillips Brandon , Narayanan Ranga
Published: January 2023

The dynamics of levitated liquid droplets can be used to measure their thermophysical properties by correlating the frequencies at which normal modes of oscillation most strongly resonate when subject to an external oscillatory force. In two preliminary works, it was shown via electrostatic levitation and processing of various metals and alloys that (1) the resonance of the first principal mode of oscillation (mode n = 2) can be used to accurately measure surface tension and (2) that so-called “higher-order resonance” of n = 3 is observable at a predictable frequency. It was also shown, in the context of future space-based experimentation on the Electrostatic Levitation Furnace (ELF), a setup on the International Space Station (ISS) operated by Japan Aerospace Exploration Agency (JAXA), that while the shadow array method in which droplet behavior is visualized would be challenging to identify the n = 3 resonance, the normal mode n = 4 was predicted to be more easily identifiable. In this short communication, experimental evidence of the first three principal modes of oscillation is provided using molten samples of Tin and Indium and it is subsequently shown that, as predicted, an “image-less" approach can be used to identify both n = 2 and n = 4 resonances in levitated liquid droplets. This suggests that the shadow array method may be satisfactorily used to obtain a self-consistent benchmark of thermophysical properties by comparing results from two successive even-mode natural frequencies.
Magnetically mediated hole pairing in fermionic ladders of ultracold atoms
Authors: Hirthe Sarah , Chalopin Thomas , Bourgund Dominik , Bojović Petar , Bohrdt Annabelle , Demler Eugene , Grusdt Fabian , Bloch Immanuel , Hilker Timon A.
Published: January 2023

Conventional superconductivity emerges from pairing of charge carriers—electrons or holes—mediated by phonons1. In many unconventional superconductors, the pairing mechanism is conjectured to be mediated by magnetic correlations2, as captured by models of mobile charges in doped antiferromagnets3. However, a precise understanding of the underlying mechanism in real materials is still lacking and has been driving experimental and theoretical research for the past 40 years. Early theoretical studies predicted magnetic-mediated pairing of dopants in ladder systems4–8, in which idealized theoretical toy models explained how pairing can emerge despite repulsive interactions9. Here we experimentally observe this long-standing theoretical prediction, reporting hole pairing due to magnetic correlations in a quantum gas of ultracold atoms. By engineering doped antiferromagnetic ladders with mixed-dimensional couplings10, we suppress Pauli blocking of holes at short length scales. This results in a marked increase in binding energy and decrease in pair size, enabling us to observe pairs of holes predominantly occupying the same rung of the ladder. We find a hole–hole binding energy of the order of the superexchange energy and, upon increased doping, we observe spatial structures in the pair distribution, indicating repulsion between bound hole pairs. By engineering a configuration in which binding is strongly enhanced, we delineate a strategy to increase the critical temperature for superconductivity.
Coherent correlation imaging for resolving fluctuating states of matter
Authors: Klose Christopher , Büttner Felix , Hu Wen , Mazzoli Claudio , Litzius Kai , Battistelli Riccardo , Zayko Sergey , Lemesh Ivan , Bartell Jason M. , Huang Mantao , Günther Christian M. , Schneider Michael , Barbour Andi , Wilkins Stuart B. , Beach Geoffrey S. D. , Eisebitt Stefan , Pfau Bastian
Published: January 2023

Fluctuations and stochastic transitions are ubiquitous in nanometre-scale systems, especially in the presence of disorder. However, their direct observation has so far been impeded by a seemingly fundamental, signal-limited compromise between spatial and temporal resolution. Here we develop coherent correlation imaging (CCI) to overcome this dilemma. Our method begins by classifying recorded camera frames in Fourier space. Contrast and spatial resolution emerge by averaging selectively over same-state frames. Temporal resolution down to the acquisition time of a single frame arises independently from an exceptionally low misclassification rate, which we achieve by combining a correlation-based similarity metric1,2with a modified, iterative hierarchical clustering algorithm3,4. We apply CCI to study previously inaccessible magnetic fluctuations in a highly degenerate magnetic stripe domain state with nanometre-scale resolution. We uncover an intricate network of transitions between more than 30 discrete states. Our spatiotemporal data enable us to reconstruct the pinning energy landscape and to thereby explain the dynamics observed on a microscopic level. CCI massively expands the potential of emerging high-coherence X-ray sources and paves the way for addressing large fundamental questions such as the contribution of pinning5–8and topology9–12in phase transitions and the role of spin and charge order fluctuations in high-temperature superconductivity13,14.
Vertical organic electrochemical transistors for complementary circuits
Authors: Huang Wei , Chen Jianhua , Yao Yao , Zheng Ding , Ji Xudong , Feng Liang-Wen , Moore David , Glavin Nicholas R. , Xie Miao , Chen Yao , Pankow Robert M. , Surendran Abhijith , Wang Zhi , Xia Yu , Bai Libing , Rivnay Jonathan , Ping Jianfeng , Guo Xugang , Cheng Yuhua , Marks Tobin J. , Facchetti Antonio
Published: January 2023

Organic electrochemical transistors (OECTs) and OECT-based circuitry offer great potential in bioelectronics, wearable electronics and artificial neuromorphic electronics because of their exceptionally low driving voltages (<1 V), low power consumption (<1 µW), high transconductances (>10 mS) and biocompatibility1–5. However, the successful realization of critical complementary logic OECTs is currently limited by temporal and/or operational instability, slow redox processes and/or switching, incompatibility with high-density monolithic integration and inferior n-type OECT performance6–8. Here we demonstrate p- and n-type vertical OECTs with balanced and ultra-high performance by blending redox-active semiconducting polymers with a redox-inactive photocurable and/or photopatternable polymer to form an ion-permeable semiconducting channel, implemented in a simple, scalable vertical architecture that has a dense, impermeable top contact. Footprint current densities exceeding 1 kA cm−2 at less than ±0.7 V, transconductances of 0.2–0.4 S, short transient times of less than 1 ms and ultra-stable switching (>50,000 cycles) are achieved in, to our knowledge, the first vertically stacked complementary vertical OECT logic circuits. This architecture opens many possibilities for fundamental studies of organic semiconductor redox chemistry and physics in nanoscopically confined spaces, without macroscopic electrolyte contact, as well as wearable and implantable device applications.
Spontaneous behaviour is structured by reinforcement without explicit reward
Authors: Markowitz Jeffrey E. , Gillis Winthrop F. , Jay Maya , Wood Jeffrey , Harris Ryley W. , Cieszkowski Robert , Scott Rebecca , Brann David , Koveal Dorothy , Kula Tomasz , Weinreb Caleb , Osman Mohammed Abdal Monium , Pinto Sandra Romero , Uchida Naoshige , Linderman Scott W. , Sabatini Bernardo L. , Datta Sandeep Robert
Published: January 2023

Spontaneous animal behaviour is built from action modules that are concatenated by the brain into sequences1,2. However, the neural mechanisms that guide the composition of naturalistic, self-motivated behaviour remain unknown. Here we show that dopamine systematically fluctuates in the dorsolateral striatum (DLS) as mice spontaneously express sub-second behavioural modules, despite the absence of task structure, sensory cues or exogenous reward. Photometric recordings and calibrated closed-loop optogenetic manipulations during open field behaviour demonstrate that DLS dopamine fluctuations increase sequence variation over seconds, reinforce the use of associated behavioural modules over minutes, and modulate the vigour with which modules are expressed, without directly influencing movement initiation or moment-to-moment kinematics. Although the reinforcing effects of optogenetic DLS dopamine manipulations vary across behavioural modules and individual mice, these differences are well predicted by observed variation in the relationships between endogenous dopamine and module use. Consistent with the possibility that DLS dopamine fluctuations act as a teaching signal, mice build sequences during exploration as if to maximize dopamine. Together, these findings suggest a model in which the same circuits and computations that govern action choices in structured tasks have a key role in sculpting the content of unconstrained, high-dimensional, spontaneous behaviour.