Clinical study of benign endometrial hyperplasia and response of Unani drugs with estimation of serum oestrogen levels
Authors:   Department	of	Surgery,	Government	Nizamia	Tibbi	College,	Hyderabad,	Telangana	500002,	India, Samreen , Ateka , Sultana Shahzadi ,   Department	of	Ilmul	Qabalat	Wa	Amraz	e	Niswan,	Government	Nizamia	Tibbi	College,	Hyderabad,	Telangana	500002,	India
Published: February 2024

Endometrial Hyperplasia represents a spectrum of irregular morphological alterations, made by abnormal proliferation of the endometrial glands results in an increase in gland to stroma ratio. When compared to endometrium from proliferation phase of the cycle. The proliferation glands in endometrial hyperplasia can vary greatly in size and shape, and cytological atypia may be present. According to Hakeem Ajmal Khan in his book HAZIQ,Hakeem Anwer Ali Khan in his book Taleem-ul Qabela and Hakeem Shafaqat Azmi in his book Amraaz –e- Niswaan said that the Endometrial hyperplasia is caused due to alteration of humors and the temperament of uterus and the increase in retaining power (quwat-e- masika) of uterus is the cause of thickening of inner layer of uterus which leads to warm-e- daroone- raham. Objective: To prove the eficacy of Unani medicine in Benign Endometrial Hyperplasia Methodology: The study was carried out in the P.G Department of Qabalath – O – Amraaz – E – Niswaan at Government Nizamia Tibbi College and Hospital, Charminar, Hyderabad. Randomized single blind study with Pre and Post-test evaluation was conducted. Total 40 cases of Endometrial Hyperplasia were selected which is divided into two Groups. Group A – 20 Cases and Group B – 20 Cases. Inclusion Criteria: Age 25Yrs. to 55 Yrs., Only married women, Simple Hyperplasia with cystic without atypia, Complex hyperplasia with adenomatous without atypia, History of irregular menstrual cycles, PCOD's, Hormone replacement therapy (HRT). Exclusion Criteria: Simple Hyperplasia with cystic Atypia, Complex Hyperplasia with Adenomatous Atypia/Carcinoma in Situ, Uterine Fibroids, Uterine Polyps, PID (Pelvic Inlammatory Disease), Systemic Disorders like tuberculosis, heart Diseases, Renal Disorders & Neurological Disorder, Unmarried Women. Drugs which were selected for trial were inalized on the basis of these following properties like Mohalil – e- Aoram, Qhabiz, Musafi – E – Khoon & Dafae Tafoon were selected for the study. In group A & B drugs given in the form of Joshanda, Sufoof, Humool and Zimaad. Group A- JOSHANDA: Gul – e – Banafsha, Babuna, Tukhm – e – Kataan, Sumbul e Tib, Gul – e – Tisu, Makoh – e – Khuskh, Arjun Chall, Gul – e – Surkh. HUMOOL: Mazo, Gul – e – Surkh, Shib – e – Yamani, Chub Zard, Zulal – e- Tukhme Bartang. SUFOOF: Musli Safaid, Mushtagi, Mochras, Gul – e – Surkh, Maye Kalan. ZIMAAD: Gul- e – Banafsha, Makoh – e – khuskh, Magaz – e – Fuloos – e- Qayashambar, Kashneez – e- Sabz, Tukhme Alsi. Group B – JOSHANDA: Gul – e – Banafsha, Babuna, Tukhm – e – Kataan, Sumbul e Tib, Gul – e – Tisu, Makoh – e – Khuskh, Arjun Chall, Gul – e – Surkh. HUMOOL: Luab – e – Tukhme Alsi, Luab –e- Tukhme Khatmi, Aab – e – Kashneez Sabz, Gul – e- Surkh, Makoh – e – Khushk. SUFOOF: Gul – e – Dhava, Gul- e- Gaozaban, Gul – e- Surkh, Gul – e – Banafsha. ZIMAAD: Gul – e – Tisu, Gul – e – Banafsha, Raswat, Tukhme Alsi, Magz – e – Gheegawar. Results: Group A 8 patients (40%) cured; 7 patients (35%) Partially relieved. Where as in Group B 11 patients (55%) cured and 7 patients (35%) Partially relieved. Conclusion: The study proved eficacy of Unani formulation with good results in Benign Endometrial Hyperplasia with no major side effects.