bluuebunny/crossref_metadata_2025 huggingface dataset:
EFEKTIVITAS YOUTUBE SEBAGAI MEDIA PEMBELAJARAN PADA MATA PELAJARAN PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN (PPKn)
Authors: Indriyati
Published: August 2023

Penelitian ini bertujuan untuk mengetahui efektivitas youtube sebagai media pembelajaran pada mata pelajaran pendidikan pancasila dan kewarganegaraan (PPKn) di Madrasah Aliyah Negeri (MAN) 1 Banyumas Provinsi Jawa Tengah semester genap tahun pelajaran 2022/2023. Peneliti merupakan kreator konten Youtube Channel BUNDA INDRI. Penelitian ini menggunakan kuesioner yang diberikan kepada pengunjung Channel Youtube BUNDA INDRI. Subjek penelitian adalah siswa SMA/MA/SMK yang berkunjung ke Channel BUNDA INDRI. Waktu yang digunakan untuk penelitian yaitu satu bulan, pada bulan Januari sampai dengan bulan Februari 2023. Tahap persiapan penelitian dilaksanakan dalam satu minggu, tahap pengumpulan dan pengolahan data dilaksanakan dalam dua minggu, dan tahap penulisan satu minggu. Langkah-langkah penelitian yaitu, kuesioner dibagikan melalui kolom deskripsi, responden menjawab kuesioner pada kolom komentar, langkah selanjutnya pengumpulan hasil jawaban responden, pengolahan dan análisis data, penyimpulan dan penulisan laporan hasil penelitian. Hasil penelitian menunjukkan bahwa dalam pembelajaran mata pelajaran Pendidikan Pancasila dan Kewarganegaraan (PPKn), media Youtube lebih menarik bagi siswa. Youtube membantu siswa dalam memahami materi pelajaran pada mata pelajaran Pendidikan Pancasila dan Kewarganegaraan (PPKn). Waktu belajar siswa lebih rileks atau santai dengan menggunakan media Youtube. Beban belajar siswa juga menjadi lebih ringan dengan menggunakan media Youtube. Berdasarkan hasil penelitian dapat disimpulkan bahwa Youtube efektif sebagai media pembelajaran pada mata pelajaran Pendidikan Pancasila dan Kewarganegaraan (PPKn) dapat diterima.
EFEKTIFITAS PENERAPAN PROJECT BASED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR MATERI BERIMAN KEPADA HARI AKHIR PADA SISWA SMAN 3 MATARAM
Authors: ASMAWATI
Published: August 2023

Tujuan dari penelitian ini adalah untuk mengetahui peningkatan hasil belajar siswa pada mata pelajaran PAI materi Beriman Kepada Hari Akhir pada siswa kelas XII SMA Negeri 3 Mataram dengan penerapan Project Based Learning. Penelitian ini merupakan jenis penelitian tindakan kelas (classroom action research) untuk mengatasi permasalahan yang ada di dalam kelas. Subjekpenelitian yang digunakan adalah siswa kelas XII SMA Negeri 3 Mataram di semester 1 tahun pelajaran 2022/2023 yang berjumlah 36 siswa. Penelitian dilakukan dalam dua siklus dan setiap siklus dilakukan refleksi terhadap tindakan yang diberikan. Teknik pengumpulan data menggunakan lembar observasi, tes hasil belajar, tugas proyek dan dokumentasi. Metode untuk analisis data yaitu dengan metode analisis deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa pelaksanaan pembelajaran dengan penerapan Project Based Learning pada mata pelajaranPAI materi Beriman Kepada Hari Akhir dapat meningkatkan aktivitas belajar dan hasil belajar siswa. Hal ini dapat dilihat pada Pra Siklus skor rata-rata hasil belajar siswa 60,14 dengan 14 dari 36 siswa yang tuntas meningkat pada Siklus I yaitu 68,33 dengan 17 siswa yang tuntas kemudian pada Siklus II meningkat lagi yaitu 86,25 dengan 30 siswa yang tuntas dari 36 siswa di kelas XII SMA Negeri 3 Mataram. Sedangkan persentase ketercapaian KKM juga meningkat dari Pra Siklus 38,89%, meningkat pada Siklus I sejumlah 47,22% dan meningkat lagi menjadi 83,33% pada Siklus II. Dari data penelitian yang didapatkan dapat disimpulkan bahwa penerapan Project Based Learning telah berhasil meningkatkan hasil belajar PAI materi Beriman Kepada Hari Akhir pada siswa kelas XII SMA Negeri 3 Mataram sehingga layak untuk diterapkan di SMA Negeri 3 Mataram Provinsi Nusa Tenggara Barat.
PENGARUH E-MODUL BAHASA INDONESIA TERHADAP HASIL BELAJAR MAHASISWA PROGRAM STUDI TEKNOLOGI PENDIDIKAN UNDIKMA
Authors: Farida Fitriani, M.Pd.
Published: August 2023

Tujuan Penelitian ini untuk mengetahui pengaruh e modul pada mata kuliah Bahasa Indonesia terhadap hasil belajar mahasiswa Teknologi Pendidikan di Fakultas Ilmu Pendidikan Universitas Pendidikan Mandalika. Jenis penelitian ini eksperimen semu (quasi eksperimen) yang bertujuan untuk mengetahui pengaruh penggunaan media pembelajaran e-modul terhadap hasil belajar mahasiswa semester II Program Studi Teknologi Pendidikan FIPP Undikma. Adapun rancangan penelitian digunakan adalah one shot case study. Hasil penelitian ini yaitu layak untuk dipergunakan dengan rincian sebagai berikut: e-modul Bahasa Indonesia telah di validasi oleh dua validator dari tampilan, isi dan bahasa dengan nilai rata-rata 86,44%. Hasil belajar mahasiswa pun dikatakan tuntas dengan nilai rata-rata 83 dari 42 mahasiswa Prodi Teknologi Pendidikan. Kemudian respon mahasiswa pun dikatagorikan baik.
Systematic Investigation of Environmental Impact between Lithiumion Battery and Sodium-ion Battery
Authors: Lei Shengwei , Zhu Hai , Li Chentong , Wang Juehao , Li Zhaotong
Published: August 2023

This paper provides significant new insights into Sodium-ion and Lithium-ion batteries’ environmental impact. Lithiumion batteries are used in commercials on a large scale. However, lithium-ion batteries are used less than sodium batteries. Considering that Sodium-ion batteries technology is not as advanced as Lithium. Sodium-ion batteries may have the potential to replace Lithium-ion batteries. According to commercial data, batteries are widely used in different areas because of their significant use in the renewable field, such as electric cars or energy storage projects. The battery has become a significant component in the renewable area. In that case, we will discuss which kind of battery will be better, especially the environmental impact. If the public cloud analyzes which battery is better, we will benefit from replacing batteries. First, the paper will discuss the environmental impact of five aspects: water pollution, Solid pollution, Raw material, Recycling, and Gas emissions. Second, according to the five aspects, we will use method AHP to analyze which battery is better. After AHP, the conclusion of which batteries are better regarding environmental impact will be given.
Why Hermès is the Top Luxury Brand
Authors: Chen Yongru
Published: August 2023

Nowadays, Hermes has gained a high reputation in the world. This article examines why Hermes can becomesuccessful. Hermes’ history, marketing strategies, and the relationship between the products and art are analyzed in thisarticle. It proves that a luxury brand must have appropriate marketing strategies and create durable products with somecultural and artistic features.
Introductory to Organic Synthesis and Retrosynthesis Analysis
Authors: Ye Yutong
Published: August 2023

Retrosynthesis is an indispensable and auxiliary technique used by chemists in assisting the organic synthesis of thecomplex desired product. This study aims to teach high school students how to do retrosynthesis analysis for organicmolecules by considering the disconnection strategies, and basic approaches, for instance, fine-tuning & protectingfunctional groups and fundamental principles when doing the analysis. It also involves some techniques that could applyto a specific pattern, such as deoxygenation. Two complex molecules are given as samples, and their retrosynthesis willbe exploited.
Does the Glandular Tolerant to McL-1 Inhibitor S63845?
Authors: Chang Xuming
Published: August 2023

MCL-1 is an anti-apoptotic protein that regulates cell apoptosis and has been observed in over-expression in manycancer. It makes the MCL-1 an available target. S63845 is introduced to treat cancer, an inhibitor with a high affinity toMCL-1. However, the tolerability of the human body to the treatment remains unanswered. Therefore in this paper, wedesigned the experiment to test the tolerability of regular issue glandular with cancerous individuals of the same cellline, the apoptosis will be tested by the MTT theory, and the direct production of inhibition --BAX will be measuredby western blot. The result is predicted, and this work will provide meaningful information for future cancer treatment.Future studies should focus on cooperation with other BCL-2 inhibitors and the impact of the treatment.
Did monetary policy cause a housing bubble in theUS in the first half of the 2000s?
Authors: Li Yuecheng
Published: August 2023

Loose monetary policy is one of the causes of the housing bubble’s burst. The relationship between monetary policy andthe housing bubble is the main topic of this essay. Through analyzing economists’ opinions, collecting data and makingregression, and evaluating the cause of the housing bubble on my own, this essay concludes that monetary policy isnot the main cause. In this essay, I consider the relationship comprehensively. I first select and evaluate two works ofliterature with different views about the relationship between the housing bubble and monetary. Then in the discussionpart, I draw on both ideas and find other arguments to draw my conclusion. This essay announces that the housingbubble is affected by various factors, and monetary policy is just one of them.
Optimizing Container CNI Metrics for Improved Service LevelIndicators and Objectives in Container Networking
Authors: Ou Yining
Published: August 2023

Container networking is a critical component of cloud computing, providing the infrastructure for the deployment andscaling of containerized applications. However, ensuring high-performance and reliable container networking can bechallenging due to the complexity of container network architectures and associated metrics. This paper proposes a newapproach to optimize container CNI (Container Network Interface) metrics to improve service level indicators (SLIs)and objectives (SLOs) in container networking. The approach involves analyzing key CNI metrics, such as networklatency, bandwidth, and packet loss, and fine-tuning them to optimize network performance and availability. This studyconducted experiments on Kubernetes clusters to validate the approach using different CNI plugins and workloads. Theresults show that optimizing CNI metrics can significantly improve network performance, reduce network downtime,and enhance the overall service level of container networking. The proposed approach provides a practical and effectivesolution for managing container network performance and availability and has the potential to benefit a wide range ofcloud-based applications.
Diet problem by using Linear Programming
Authors: Ding Shengtai , Wang Ruokai , Hu Ke
Published: August 2023

This paper will discuss the eating problems people encounter daily, mainly using Stigler’s idea. This dietary problem refers to how people can buy the food they need at the most affordable cost under balanced nutrition. Therefore, this paper uses linear programming to optimize this dietary problem. It contains nine nutrients, each of which has a minimum value. However, two of them, vitamin A and calcium, were set to have the highest intake amount. These intake settings are universal to all human beings, without exception. The algorithm applied to solve this linear programming is a simplex method, and a positive result is obtained. Our resulting minimum cost is even slightly cheaper than Stigler’s result. We conclude that if the taste of foods is not considered, people can obtain the required nutritional content by spending very little money. While it might not seem useful in modern countries, it is a meaningful investigation for underprivileged people who live in extreme poverty. However, the number of food considered in this paper is still limited. Also, the data we included come from the twentieth century for comparison with Stigler, which is already outof-date. Therefore, given that the diet problem is a topic worth investigating, further research with more comprehensive food choices and more up-to-date data is needed.
Utilizing Artificial Intelligence and Machine Learning to FacilitateAchieving Carbon Neutrality
Authors: Shen Ruoyu
Published: August 2023

With global waste production rising, efficient waste management practices are crucial for environmental sustainability.Artificial Intelligence (AI) offers a promising solution, particularly in waste classification. By automating wasteclassification, AI can reduce the time and cost associated with traditional manual sorting while improving accuracyand reducing carbon emissions. This paper provides an overview of the potential of AI in waste classification andmanagement, including machine learning and deep learning algorithms such as Convolutional Neural Networks. Thepaper also emphasizes the importance of proper waste management for achieving carbon neutrality and how AI cancontribute to this goal by promoting recycling, composting, and circular economy principles. Finally, this paper presentsan experimental application of deep learning for garbage classification and suggests potential improvements based onthe results. Overall, this paper highlights the critical role of AI in waste management and its potential to revolutionizewaste classification and management while contributing to achieving carbon neutrality goals.
The Effect of Sodium Content in Food on the appetite of the ObesePeople: A Research Proposal on Cognitive Diversity
Authors: Wu Xinfeng , Wu Rui
Published: August 2023

Previous studies showed that people with obesity respond to high- or low-calorie foods differently from those withthe standard Body Mass Index (BMI). Nevertheless, as suggested by the previous paper, sodium might be a clue thatleads to high-calorie food intake, which then induces obesity. Also, the synergy between eating high-calorie food andhigh-sodium food was found to be one of the mechanisms that developed obesity. However, no study has been done toinvestigate the effect of sodium food on the appetite of people suffering from obesity. To find out this question, we willconduct behavior tests, including lexical decisions and visual stimulation, to determine whether the sodium componentin the food can be a way to define the food stimuli that develop eating addiction in obesity population. Besides, we willcompare which delivery of this kind of stimuli, through pictures or words, will affect the results more, if possible.
The Potential Stickiness of Pandemic-Induced Behavior Changesamong Adolescents: The Case of Video Game
Authors: Wang Fanyue
Published: August 2023

The outbreak of the COVID- 1 9 in early 2 0 2 0 generated perhaps the largest disruption in changing humanbehavior and choices. Going forward, A critical question is how these experiences have changed preferencesand habits in ways that might persist after the pandemic ends. This paper explores the time commitment changeadolescents put on video games after experiencing the pandemic to provide concrete evidence of behavioral stickiness.Using the online survey of 412 adolescents, the paper confirms the stickiness in video game time among adolescents.Interestingly, adolescents who experienced the quarantine caused by the COVID- 19 has less game time increases thanthose who did not. The paper also addresses that game-playing history, age, and parenting time are good predictors forsuch stickiness.
Mono-no-aware aesthetics in Japanese art texts (Draft 3)
Authors: Lin Ziming
Published: August 2023

The concept of mono-no-aware aesthetics was first introduced by the Japanese literary scholar Motoori Norinaga inhis commentary book げんじものがたりたまのおぐし . As the first of the three central Japanese aesthetic ideas,Mono no aware has profoundly influenced the expression of Japanese artistic texts. In this paper, we will look at severalJapanese fiction and film texts to explore the emotional pursuits and philosophies of life expressed by the authors andfelt by the readers and the cultural connotations behind them.
Intelligent Class-based Math Theory Searching Software-- Report of 8-hour Fujen PBL course
Authors: Wen Chentao , Ying Tianbo
Published: August 2023

Artificial intelligence is gradually becoming the forefront of technological development under the advancementof the fourth industrial revolution. Its application in education has also been developed to a great extent. Artificialintelligence can help to improve the quality and efficiency of education teaching so that students can learn the correctand more suitable content more quickly and effectively. In this paper, an app for artificial intelligence in education willbe proposed, explained, and analyzed. The discussion is divided into six parts: app design overview, automatic textrecognition in intelligent teaching systems, modeling, educational data mining, evaluation, and embedded experiments.
Downregulating MK5 to reduce immune escape induced by thebinding of PD-1 with PD-L1 in NSCLC
Authors: Andrew  , Wang Yifei
Published: August 2023

Lung cancer is the leading cause of cancer death in both men and women worldwide. Previous studies have indicatedthat MK5 stabilizes Yes-associated Protein (YAP) in LATS1/2-null RPE1 cells, and YAP regulates PD-L1 expression inNSCLC. Since previous studies did not associate MK5 KO with PD-L1 expression in NSCLC, this study investigateswhether downregulating MK5 in the H1299 cell line using MK5 CRISPR will reduce the expression of PD-L1 both invitro and in vivo conditions for NSCLC. The negative control is a scrambled CRISPR targeting vector, and the positivecontrol is the depletion of MK5. Through western blot and MTT in vitro and xenograft in vivo, the paper investigateswhether or not downregulating MK5 will reduce immune escape induced by the binding of PD-1 with PD-L1 inNSCLC.
Oridonin inhibits breast cancer cell proliferation and migrationthrough suppressing COX-2 expression
Authors: Yao Yue
Published: August 2023

Oridonin, a biologically active substance isolated from the plant Rabdosia rubescens, is recently reported to have aninhibitory effect on breast cancer. However, its mechanism is still unclear. According to previous findings, increasedCOX-2 expression has been associated with a higher incidence of breast cancer. Therefore, this study aims to explorewhether oridonin inhibits cell proliferation and migration by suppressing the expression of COX-2 in human breastcancer cells MDA-MB-231 in vitro and in vivo conditions. In this study, human breast cancer cells MDA-MB-231will be treated with increasing concentrations and for various durations with oridonin to investigate whether oridonininhibits cell migration, decrease proliferation, and reduce tumors in mice through suppressing the expression of COX2. A positive control is a taxol. A negative control is medium. Cell migration will be tested by Transwell assay. Theproliferation will be detected by MTT assay. The western-blotting assay will be used for COX-2. In nude mice, the invivo anti-tumor efficacy of oridonin will be examined. The study’s result will provide insight into the effect of oridoninon the proliferation and migration of human breast cancer cells MDA-MB-231. It will also provide reference for themechanism of how oridonin inhibits breast cancer and lay the foundation for future studies on the molecular basis oforidonin’s pharmacological activity in the future.
Long Noncoding-RNA Component of Mitochondrial RNA ProcessingEndoribonuclease Promotes Gastric Cancer Cell Multiplication,Migration, and Invasion
Authors: Yang Xinyue
Published: August 2023

Since RMRP was found to target microRNA-766-5p (miR-766-5p) in TNBC cells, it enhanced cell viability anddecreased apoptosis by silencing miR-766-5p. Additionally, RMRP has been proven to be highly involved ineither pathological or physiological processes. Therefore, the study aims to determine whether RMRP promotesthe multiplication, migration, and invasion of gastric cancer cells. The study will overexpress RMRP in GC1401gastric cancer cells and measure cell growth by MTT assay, migration by wound healing assay, and Boyden chamberassay. Positive control is another treatment previously shown to increase cancer cell growth and migration, such asIQGAP3, which, beginning with the early stages of tumor growth, is markedly up-regulated in human stomach cancer.Furthermore, the negative control is DMSO. The study measures miR206 by qRTPCR. If the solution gets dark throughMTT assay, RMRP promotes gastric cancer cell multiplication. If the migration rate is getting quicker according to thewound healing assay, and the number of migration cells increases by Boyden chamber assay, RMRP promotes gastriccancer cell migration. If miR-206 may affect the expression of HIF-1 to control cell growth and ECM buildup, RMRPpromotes gastric cancer cell invasion by acting as a miR-206 sponge for gastric cancer. The RNA component of miRNAprocessing endoribonuclease, the novel biomarker for gastric cancer, promotes gastric cancer cell multiplication,migration, and invasion by acting as a miR-206 loss of function in cell lines for gastric cancer.
A Possible Reward Prediction Error Circuit Exists in Brain: AroundPrefrontal Cortex and Ventral Tegmental Area
Authors: Yang Yongzong
Published: August 2023

This work aims to find a potential neuronal circuit from the Prefrontal cortex to the ventral tegmental area. In neurology,previous research focuses on how signal transfers from the ventral tegmental area to the Prefrontal cortex. Theoretically,the Prefrontal cortex is an effector and a processor. Therefore, a possible circuit, using the Prefrontal cortex as thedeparture, could be designed to find. This work is designed to employ some techniques, floxed genes, neuronal virustracing, and an electrical detector in the brain to prove the desired circuit and give some prediction results. Thoseresults will prove whether the neuronal circuit existed or not. If the electrical signals from the PFC region to VTA canbe detected in termination, such a desired circuit is possible. This work may help to complete the learning mechanism,reward prediction error system, physiologically.
Combined ROS-related therapy improves the efficacy of multipleneoantigen vaccines against LUAD
Authors: Lai Peijia , Cui Tianyu , Zhang Zhiheng
Published: August 2023

Lung adenocarcinoma (LUAD) is classified as Non-Small-Cell Lung Cancer (NSCLC), one of the most malignantcancers due to its poor prognosis and fast progression. Its resistance to chemotherapy, immunosuppressive tumormicroenvironment (TME), and frequent immune evasion also impose enormous obstacles in treating LUAD. However,previous research found that these tumor cells resistant to chemotherapies commonly increase their production ofintracellular reactive oxygen species (ROS) due to high mitochondria activity. Antioxidants like glutathione (GSH)are also highly produced to maintain their redox homeostasis. Therefore, the depletion of antioxidants which can leadto intratumoral accumulation of ROS to cytotoxic levels, provides a new therapeutic target. Besides, the high levelof extracellular ROS also significantly contributes to the immunosuppressive characteristic of TME, which exhaustsactivated T cells. This work provides the framework for a novel combinational therapy based on a multiple-neoantigenvaccine to avoid immune evasion. Two types of nanoparticles further boost the vaccine’s efficacy against tumors, onedepleting intratumoral GSH and scavenging extracellular ROS. Anticipated results are shown from various aspects,hoping the innovative treatment can effectively improve the survival rate with few side effects.
The Dynamic Transmission of Anxiety Disorder under Emotional Infection
Authors: Wang Ruoxi , Li Mingxuan , Huang Sichen
Published: August 2023

In previous studies, we noted that by comparing anxiety and depression and co-morbidity natural mortality, and unnatural mortality, we concluded that anxiety disorders have an investigability independent of depression. Also, previous studies have concluded that emotional infection significantly transmits negative emotions. This paper proposes a compartmental model including the population in a mildly anxious and severely anxious environment. The propagation of anxiety in the population in response to emotional contagion is investigated in different fixed settings.
A Study on the Impact of Digital Inclusive Financeon the Urban-Rural Income Gap
Authors: Feng Chenchen
Published: August 2023

Chinese provincial panel data from 2011-2020 are selected to empirically demonstrate the impact of digital inclusivefinance and its sub-dimensional indices on the urban-rural income gap using a panel fixed effects model. The findingsshow that digital inclusive finance narrows the urban-rural income gap in China, and the conclusions still hold afterusing instrumental variables to deal with endogeneity; there is regional heterogeneity in the effects of digital inclusivefinance and its sub-dimensional indices on the urban-rural income gap.
The Hindsight Bias and Its Applications
Authors: Gao Lining
Published: August 2023

The hindsight bias, also known as the “I knew it all along” effect, is a psychological phenomenon in which a personbelieves they predicted the outcome of an event, even if they did not act on their “prediction.” Individuals can beaffected by the hindsight bias to confidently overestimate their judgment, which can have severe consequences. Also,it can negatively affect all aspects of society to varying degrees. Social experiments have demonstrated that thisphenomenon exists in the investment industry, politics, and the law. It can be detrimental to individuals, affect theoutcome of political elections, and compromise the impartiality of police evaluations. Due to the impact of hindsightbias, there are several suggested ways to prevent this bias, and it is essential to understand how to prevent and accountfor it.
Market Strategy of Vivo
Authors: Yuan Yitian
Published: August 2023

This literature review focuses on the market strategy used in the mobile phone market. In the market, mobile brandsincreasingly optimize product systems to meet the different needs of consumers, combine in-person services with onlineadvertisement to attract consumers, and cooperate with other brands to improve their reputation. This paper takes abrand from China called Vivo as an example to illustrate those strategies. By analyzing the strategy of Vivo, it showsthat following consumers’ needs, improving technology, and finding a partner to cooperate with is the key for a brand tosurvive in such a market.
Oxaliplatin: an effective treatment in colorectal cancer
Authors: Yang Yuxuan
Published: August 2023

Colorectal cancer is one of the most common malignancies around the world. Oxaliplatin is a new platinum compoundwith promising activity in colorectal cancer treatment. Based on the analysis of preclinical data. Because Oxaliplatincan lead to ICD (Immunogenic cell death), the study aims to figure out whether increasing concentrations and treatmentdurations with Oxaliplatin can kill colorectal cancer cells to test whether Oxaliplatin has a significant effect on colorectalcancer treatment. Using the human colorectal cancer cell line HCT116, the cancer cells will be treated with Oxaliplatinand PBS (negative control) at concentrations 1 mM, 10 mM, or 100 mM in a dose-dependent and duration-dependentmanner (1,3,6,12,24 hours ). Measure killing in vitro with MTT assay and measure tumor size in vivo. Also, measureHMGB-1 released by western blot and CRT by FACS. The positive control is cisplatin, and the negative is PBS/DMSOfor in vitro and saline solution for in vivo. The study’s findings will supply insight into the latent capacity of Oxaliplatinas a treatment for colorectal cancer in the future.
The differences in brain structures and blood flow between male and female
Authors: Zhao BeiChen
Published: August 2023

This paper will analyze the sex differences found in brain anatomy. In particular, the grey and white matter, the cerebral blood flow, and more specific regions will be investigated. The global volume and particular areas of grey matter, white issue, and blood flow will be included. Their differences will also have some emotional factors discussions. Information and data collected from papers before are used to conclude the end. Men undoubtedly have a more considerable brain volume, and females have higher total cerebral blood flow. The sizes and neuron numbers in the specific constituents still doubt it. The possible purpose of such research is to develop in the sociology and medical sectors.
Parallel Teaching and Evaluation of Employability and Foreign Language Competencies in Technical Language Training
Authors: Hajdu Zita , Tar Ildikó , Lázár Tímea , Farkas János , Czellér Mária
Published: August 2023

An increasingly important expectation of today’s labour market is the group of employability skills. That is the reason why the Institute of Business Communication and Professional Language Studies at Debrecen University found it essential to introduce the development of these highly demanded competences in the curriculum of the technical language courses. The paper describes how workplace skills and foreign language competencies can be compiled in one curriculum with particular emphasis on the application of IT skills in foreign language courses. Since a major task of universities is to prepare students for the tasks of assessment centres and other stages of the selection process, the testing of non-cognitive skills should also be integrated into the teaching material. The expected results of the program include: achieving a higher level of professional language and soft skills, increased student confidence in workplace situations and improved general communication skills.
PERFIL METABOLÔMICO IDENTIFICA ASSOCIAÇÃO DA VIA GLICOLÍTICA COM A RESISTÊNCIA À APARAGINASE EM LINHAGENS CELULARES DE LEUCEMIA LINFOBLÁSTICA AGUDA
Authors: Melo Carolina Pereira de Souza , Canevarolo Rafael Renatino , Brandalise Silvia Regina , Zeri Ana Carolina de Mattos , Yunes José Andrés
Published: August 2023

A resposta precoce à terapia na leucemia linfoblástica aguda (LLA) pediátrica pode ser atribuída principalmente à resistência intrínseca dos linfoblastos leucêmicos à quimioterapia. Neste estudo, nosso objetivo foi determinar o perfil metabólico de linhagens celulares resistentes e sensíveis a L-asparaginase (ASNase) após o tratamento com a mesma utilizando metabolômica por RMN. As linhagens celulares de LLA Nalm6, Nalm21, REH e RS4;11 foram cultivadas em meio RPMI 1640 com 10% de SFB, suplementado ou não com ASNase (0,8 UI/ml). Após 24hs, os espectros de RMN do meio de cultura foram adquiridos e quantificados. A análise de PCA não supervisionada das concentrações obtidas dos metabólitos mostrou que o meio de cultura de células resistentes é caracterizado por níveis mais baixos de glicose e mais elevados de lactato. Curiosamente, a inibição da via da glicólise aumentou sinergicamente a sensibilidade das linhagens celulares resistentes à ASNase (Fsyn = 0,19 para Nalm6 e Fsyn = 0,50 para REH), mas não das sensíveis (Fsyn = 1,11 para Nalm21 e Fsyn = 1,85 para RS4;11). Concluindo, este estudo apresenta uma potencial abordagem metabolômica para a identificação não apenas de pacientes com possível resistência ao tratamento, mas também de moléculas-alvo para o desenvolvimento de futuras intervenções terapêuticas.
ACONSELHAMENTO GENÉTICO NO CÂNCER GINECOLÓGICO HEREDITÁRIO
Authors: Chami Anisse Marques , Zózimo Thalía Rodrigues de Souza , Braga Leticia da Conceição , Silva Filho Agnaldo Lopes da
Published: August 2023

O câncer epitelial de ovário e o câncer de endométrio apresentam uma alta taxa de mortalidade entre mulheres de todas as idades. Tanto na avaliação diagnóstica quanto de risco para essas neoplasias malignas deve-se considerar a possibilidade de uma etiologia hereditária, a qual pode ser identificável através de testes genéticos. O câncer de ovário de origem epitelial é um dos cânceres com maior relação com a hereditariedade, até 25% dos casos apresentam mutações germinativas identificáveis. Síndromes e/ou genes de alto risco para o câncer ginecológico como a Síndrome de predisposição ao câncer de mama e ovários associadas aos genes BRCA1/2, síndrome de Lynch aos genes MMR, Síndrome de Cowden ao gene PTEN, devem ser reconhecidas e podem ter impacto relevante para guiar condutas cirúrgicas e oncológicas. Entretanto, a abordagem faz-se através do processo do aconselhamento genético que é um processo dinâmico e que pode ser decisivo na avaliação do paciente oncológico e familiares em risco para câncer.
BAP1, BIOMARCADOR DE PROGNÓSTICO EM GLIOBLASTOMA?
Authors: Oliveira Anna Carolina Tavares de , Pereira Ramon de Alencar , Amorim Izabela Ferreira Gontijo de , Henriques Leonardo Augusto Wendling , Salles Paulo Guilherme de Oliveira , Oliveira Marcelo Magaldi Ribeiro de , Braga Leticia da Conceição
Published: August 2023

O diagnóstico tardio é um fator que determina mau prognóstico para os pacientes com câncer, especialmente para tumores cerebrais agressivos, como o glioblastoma (GBM), em que a taxa de sobrevida média, em 1 ano, chega a 30% dos casos. Neste contexto, a busca por biomarcadores para detecção precoce da doença e avaliação prognóstica é de fundamental importância para melhorar os resultados clínicos dos pacientes com GBM. O presente estudo trata-se de uma revisão bibliográfica do tipo narrativa. Foram analisados 33 artigos, selecionados entre os anos de 2007 a 2022, considerando a proteína BAP1 e sua relação com o estabelecimento do GBM. O gene BAP1, localizado no locus 3p21.1, codifica o domínio catalítico primário da proteína BAP1, que tem como função remover sinais de ubiquitina de substratos proteicos. BAP1 atua em diversas vias de sinalização celular, tais como: morte celular, controle do ciclo e proliferação celular, resposta de danos ao DNA e modificação da cromatina e quando alterado favorece o estabelecimento de uma neoplasia.  Embora, a proteína BAP1 tenha sido considerada como um biomarcador tumoral candidato a avaliar prognóstico em diferentes tipos de tumores, mais investigações são necessárias para elucidar melhor as interações desse alvo e seu potencial papel como biomarcador em tumores do sistema nervoso central, incluindo GBM.
Tinjauan Hukum Tindak Pidana Plagiarisme Karya Ilmiah
Authors: Perdana Syah Muhammad , Siagian Suriani
Published: August 2023

Plagiarism is an offense and an ornament to science. Plagiarists steal the work of other authors or what is commonly called cheating or plagiarizing without citing the origins of the original author. Plagiarism is an act that is vulnerable to criminal activity and this problem must be considered in as much detail as possible. The act of plagiarism is recognized as an act that is disapproved and contrary to the scientific spirit in the academic world in universities. Several types of plagiarism can be distinguished by intentional or unintentional plagiarism motivation, ways of committing plagiarism include handwriting, inappropriate paraphrasing, and summaries, plagiarism itself can be said to be recycling text, redundant or duplicate publications, data fragmentation . The purpose of this study is to find out the legal arrangements for plagiarism of scientific work in tertiary institutions and to find out the legal consequences for perpetrators of the crime of plagiarism of scientific work in tertiary institutions. The research method used by the author is normative research method which positions the law as a building system of norms. There is no law that specifically regulates plagiarism, but someone who commits plagiarism or is called a plagiarist is regulated in Article 1, Minister of National Education Regulation number 17 of 2010 concerning the prevention and control of plagiarism in tertiary institutions. There are several reasons for someone to commit plagiarism, such as the convenience obtaining information via the internet, pressure on academic assignments, poor writing skills, rushing to write under pressure, lack of knowledge and understanding of how to rewrite original references, misunderstandings to self-understand plagiarism, and habitual cheating or plagiarism, such as avoiding theft intellectual, do good writing i.e. quote and paraphrase, and try the same thing or detect plagiarism in many ways like using plagiarism apps or turnitin.

Keywords: plagiarism, legal actions, scientific works, norms
Defenisi Etika Akademik
Authors: Suryani Ira , Nasution Pebrijah , Lestari Bunga , Juliana Juliana , Kesi Kesi , Purba Nadia Haviza
Published: August 2023

Academic ethics refers to the rules or norms that govern ethical behavior in the academic world. Academic ethics includes values ​​held by the academic community, such as integrity, honesty, hard work, creativity, academic freedom, and social responsibility. Academic integrity is very important in academic ethics, because it involves honest and honorable intellectual skills and research skills. Intellectual skills include the ability to generate, collect, and analyze data, while research skills include the ability to plan, carry out, and publish high-quality research. Honesty and rigor are core values ​​of academic ethics, as they form the basis of research and teaching processes. Honesty means that academics must avoid fraud, plagiarism, and misuse of data, whereas thoroughness means that they must examine data carefully and ensure that the information they use is true and accurate. Creativity is also an important value in academic ethics, because academics are expected to produce original and innovative research and work. However, creativity must be carried out within an ethical framework and must not violate the values ​​of integrity and honesty. Academic freedom is also an important value in academic ethics, because it guarantees that academics can work independently and produce research and works that are not influenced by political or economic interests. However, academic freedom must be balanced with social responsibility, namely that academics must be responsible for the consequences of their research and teaching on society and the world. Overall, academic ethics is very important in the academic world, because it involves norms governing ethical behavior and maintaining integrity and honesty in the process of research and teaching.

Keywords: academic ethics, Islamic education
Tipologi Pengelolaan Pendidikan Pesantren: Studi Pondok Pesantren Modern Sahid Bogor
Authors: Arifin Zaenal
Published: August 2023

Pondok Pesantren is an Islamic educational institution that emphasizes the value of morality in religion as a standard for conduct in daily life. Its mission is to study, learn, investigate, live, and practice Islamic teachings. Islamic boarding schools have since seen fast development and change, giving rise to a variety of shapes and styles. The dynamics of science in the pesantren environment have been impacted by changes or modernization of Islamic education in Indonesia related to the idea of Islamic modernization in this region, such as the emergence of several Islamic boarding schools, including salaf (traditional) Islamic boarding schools, kholaf (modern), and semi-kholaf (semi-modern) Islamic boarding schools. The modernisation of boarding schools for Muslims It is difficult to ignore education, as evidenced by the changes in the growth of world culture and civilization today. Without modernization, Pesantren institutions and systems struggle to advance. The modernization of pesantren institutions and systems, however, has not been without issues or criticism. Whether there is criticism or not, in some instances, the modernization of Islamic boarding schools has proven to have many positive effects that can ultimately develop the potential of Islamic boarding schools and the potential for community development in addition to being a part of national education that should be proud of in creating and educating the nation.In this instance, the Modern Sahid Bogor Islamic Boarding School is one of many Islamic boarding schools that respond to the current reform and modernization of Islamic boarding school education management. By managing education in a contemporary manner with adequate facilities and infrastructure, and based on professional management principles based on POAC; planning (planning) Organizing (o In addition to using current management techniques, Tri Darma Service Sahid current Islamic Boarding School also implements the values of noble culture, Rumongso melu handarbeni (feeling of belonging), Wajib melu hanggondeli (Must share responsibility ), Mulat saliro hangroso wani (After introspection dare to express opinions wisely), Amanah Panca Sesotya Jati, Principal of Commitment to Work, as well as Principal of Cooperation and Community.

Keywords: boarding school, modern, typology, management.
Analisa Peran Keluarga Dalam Pelibatan Budaya Anti Kekerasan Seksual pada Anak
Authors: Alamsyah Syahril Ramadhon , Brahmono Boris , Mariyanto M Agus , Pratiwi Novi Yatri
Published: August 2023

This article provides a comprehensive overview of the role of the family in engaging in a culture of anti-sexual violence against children. This study examines sexual violence against children, the prevalence and risk factors for various types of sexual violence and discusses public knowledge and perceptions of this violence. It also examines the role of the family in a culture of anti-sexual violence in children and examines critically the meaning of a culture of anti-sexual violence in children. The diversity of literature reviews is the main qualitative method in this article, accompanied by the main focus of studies on the role of the family in anti-violence in children, examines specific cultural factors that do not only focus on cultural factors in general, but must examine the culture of non-violence in the context of modern society and consensus on international standards on human rights which are recommendations for further research.

Keywords: Family Role, Culture, sexual violence against children
Gugatan Pembatalan Pengangkatan Anak/Adopsi : Studi Kasus di Pengadilan Kota Bogor No 143/Pdt.G/2021/PN Bogor
Authors: Nurhalimah Nurhalimah , Arifin Zaenal , Noor Zairin
Published: August 2023

Children are the heirs and successors of the family lineage. Therefore, if a marriage has not or is not blessed with children, then adoption or adoption is held. The definition of adoption can be seen in etymology, terminology, and according to legal experts. But not all families get to enjoy raising a child like other families. In some families, by the power of God, where the desire to have children even after years of marriage has not been blessed, while the desire to have children is very great. So as a result, the descendants of the family will be threatened with extinction and break up if no one continues the family tree and family relatives. If this event occurs, there is a possibility of adopting a child whose origin could be from a relative, family or adopting a child who has nothing to do with family relatives (adopted) to become the successor of the lineage of the family concerned. In this study, the authors used the Sociological Juridical approach, combining juridical/legal rules combined with social facts related to the problem or object under study, namely the case of lawsuits for canceling child adoption and the type of research is descriptive research, the research aims to describe systematically, factual, and accurate, to a particular object. Regulations regarding child adoption have existed in Indonesia since the Dutch East Indies era in the form of Staadsblad No. 129 of 1917 which regulates the adoption of children which specifically applies to Chinese people until the current law, namely Government Regulation of the Republic of Indonesia No. 54 of 2007 concerning Implementation of Child Adoption and Law No. 35 of 2014 concerning Amendments to Law No. 23 of 2002 concerning Child Protection, but none of these regulations regulate the cancellation of child adoption, meaning that in Indonesia there is a legal vacuum related to regulations which regulates the cancellation of child adoption.
Applicability and performance analysis of the phase-field modelling based on the Cahn-Hilliard method for the binary alloys
Authors: Dudek Kamil , Szeliga Danuta
Published: August 2023

The Cahn-Hilliard method descries the driving force of the process of phase separation. Considering a binary (two-phase) alloy of conserved composition variable, the C-H model makes it possible to trace the process at which the domain creates pure subdomains of each component. Gururajan et al. have offered a simplified reference implementation of the aforementioned model, using the C language and FFTW libraries. It allows to perform a reverse Fourier transform to acquire a domain composition profile at a given time. Being a proof-of-concept, this approach does not stress on performance and the dedicated tools, like OpenPhase might not provide the flexibility necessary for new implementations. The following work aims on analyzing the C-H algorithm with regards of optimization, taking the Gururajan, among others, as a reference problem. Utilizing the models accompanied by replicable results facilitates the analysis of FFTW and GSL libraries, answering whether to search the replacement implementations and where (if necessary) work on code performance and parallelization. Finally, the improved model is intended to be used on external (non-random) initial composition, taken from ongoing simulations, in hope of preparation of the pearlitic steel model in the future.
Digital Image Correlation (DIC) system as a verification tool for constitutive models of deformation with complex strain path changes
Authors: Graca Paulina , Muszka Krzysztof , Majta Janusz , Perzyński Konrad
Published: August 2023

Effects of the strain path changes that occur during metal forming have been the subject of theoretical and experimental studies in the light of deformation inhomogeneities. Modern multiphase steels were used as their mechanical properties are very sensitive and strictly dependent on the combination of microstructure components with different levels of their mechanical responses. DIC as a precision tool has been used to investigate the deformation inhomogeneity during the tensile tests of specimens previously deformed with complex strain path history. The study was focused on the combined metal forming processes (i.e. Accumulated Angular Drawing (AAD), Wire Drawing (WD) and Wire Flattening (WF)). These processes are characterised by a combination of various deformation mechanisms (area reduction, torsion, bending, burnishing), and thus, are strongly affected by nonlinear strain path changes. Then, data provided in the experimental part of the work was used to assess the existing constitutive equations in the light of their applicability for the prediction of mechanical response of materials subjected to nonlinear loading conditions. In the numerical analysis, work hardening model (i.e. Chaboche model) was investigated. The results of computer simulation were then compared with the DIC measurements and conclusions regarding applicability of the proposed approach were drawn.
The method of production of thin-walled castings made of GX2CrNiMoN25-6-3 cast steel
Authors: Nadolski Maciej , Stradomski Grzegorz , Zyska Andrzej
Published: August 2023

The possibility of production of thin-walled castings made of GX2CrNiMoN25-6-3 cast steel was assessed for the exemplary final casting with variable wall thickness. The assessment both of the solidification process of the GX2CrNiMoN25-6-3 alloy and of the final degree of mould cavity filling was done by means of the NovaFlow&Solid program. The body of the casting with its variable wall thickness, including sections thinner than 1 mm, demanded for the appropriate production technology. There are presented the results of technological tests with respect to the application of the centrifugal casting, which confirm the adopted technology of pattern and mould production. The analyzed technology makes possible the production of casting of high surface quality, while simultaneously the yield is increased, and by the same the unit cost of production is lower as compared with the production method used thus far.