bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical band gap energy values in wurtzite InxGa1-xN
Authors: Inerbaev T.M. , Matsuoka T. , Kawazoe Y.
Published: September 2022

The narrow bandgap in InN has been known as a notorious example of local density approximation or generalized gradient approximation (LDA or GGA) calculations to give a metallic state. Various density functional methods are applied to optimize the atomic structures of the systems. These numerical results are used as the input values for the subsequent GW calculations, which can be applied to estimate the band gap value without phenomenological parameters. It is found that LDA with GW0 or the hybrid functional with self-consistent GW0 approximation provides sufficient theoretical results for both of the investigated compounds of GaN and InN. Although they are still time-consuming, due to less computational cost the former method is selected as a trial to compute the electronic structure in the entire range in ternary InxGa1-xN alloys without any arbitrary parameters. The present theoretical studies in ternary InxGa1-xN alloy were carried out by LDA with GW0. As a result, a good agreement between theoretical and experimental results is obtained, and it is also shown that zone bending could be well-approximated using a quadratic function with a constant, independent of x, parameter equal to 1.85 eV, which is close to the recent experimental results.
Evaluation of the Nurse-Saul method using maturity sensors for concrete strength control
Authors: Utepov Ye.B. , Aniskin A. , Tulebekova A.S. , Akhazhanov S.B. , Zharassov Sh.Zh.
Published: September 2022

The article presents the results of experimental studies on the strength of concrete grade B25 brand M350 by direct and indirect methods of control. To conduct tests, 17 cylindrical, 15 small, and 2 large cubic specimens were manufactured. 15 cylindrical specimens by 3 pieces were tested for compression in a hydraulic press on 1, 3, 7, 14, and 28 days of curing, and in the remaining two for 28 days the curing temperature was measured in order to obtain the strength-maturity relationship by the method of Nurse-Saul. The curing temperatures of the larger specimens were measured similarly, from which the concrete maturity and strength values on days 1, 3, 7, 14, and 28 were estimated. On the same days, compression tests were carried out on small specimens and by the shock pulse method on large specimens. As a result, the strength gain curves were obtained and calibration dependencies were plotted. The calibration dependencies showed a sufficiently close convergence of the results of the direct method of control (i.e., compression of small specimens) and the Nurse-Saul method of maturity, in contrast to those of the shock pulse method. The determination coefficients of these dependencies amounted to 0.9357 and 0.8965, respectively.
Selection of inoculant additives for modifying nickel alloys
Authors: Eremin E.N.
Published: September 2022

Heat-resistant nickel alloys are widely used in the production of castings for aircraft and industrial gas turbine engines. Structural factors are the main determinants of the performance properties of cast nickel alloys. The main disadvantage of castings obtained from these alloys is the coarse-crystalline structure, uneven grain size and columnar crystals in the cross-section. Therefore, the creation of an optimal alloy structure is an important condition for obtaining high properties and ensuring the increased operability of cast parts. Obtaining a fine-grained structure has a beneficial effect on the level of mechanical and operational properties of cast metal. The most promising way to create such a structure is to introduce a small number of additives into the melt that cause heterogeneous formation of crystal nuclei, i.e. modification of the melt with dispersed particles of refractory elements and inocular compounds. To select the type of inocular particles required to initiate crystallization of a particular phase, it is necessary to have a set of data that allows one to form a theoretical understanding of the principles of such a choice. The paper provides a rationale for the selection of the type of particles of inoculators capable of causing the process of artificial changes in the structure of cast metal. For a heat-resistant nickel alloy, the use of refractory particles of ultra-dispersed titanium carbo nitride powder as inoculators are the most effective. When introduced into the melt 0.025 wt. % of such particles, a fine-grained structure of the alloy is obtained, and its ductility in comparison with the unmodified one is more than doubled.
Phase transformations during the doping of zinc chloride and silver nitrate into calcium phosphates
Authors: Sagidugumar A.N. , Turlybekuly A. , Dogadkin D. , Pogrebnjak A.D. , Kantay Н. , Sadibekov A.
Published: September 2022

This article shows the results of a study on a biocomposite material based on calcium phosphate doped withZnCl and AgNO3. Calcium phosphates are mainly used in dentistry and orthopedics due to their excellent biocompatibility, osteoconductive properties and similarity to the inorganic components of human bone. The main objective of the study is to investigate the morphology, elemental and phase composition, and physicochemical properties of the obtained material. The test material is obtained in the form of a suspension and subjected to ultrasonic treatment. The microstructure and phase composition of the obtained biocomposites are studied by SEM, XRD, FTIR methods. It is possible to obtain dicalcium phosphate dihydrate (DCPD) by the presented methods, and the results demonstrate a partial replacement of calcium atoms by zinc atoms. Xray phase analysis shows that Ca(HPO4) (H2O)2 phases as well as CaZn2 (PO4)2 (H2O)2 and AgCl phases were formed during the reaction. Fourier transform infrared spectroscopy revealed that the obtained samples contain the groups HPO42 and PO43, with the group PO42 replacing the group CO32. The biocomposite materials could be of great interest in the biomedical field, including the development of coatings that prevent or delay the development of bacterial biofilm.
Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice
Authors:   Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Nickel Kaitlin , Zhu Lida
Published: September 2022

Background: Disruption of metabolic and bioenergetic homeostasis related to mitochondrial dysfunction is a key driver of aging biology. Therefore, targeting mitochondrial function would be a rational approach to slowing aging. Elamipretide (Elam, a.k.a. SS-31) is a peptide known to target mitochondria and suppress mammalian signs of aging. The present study was designed to examine the phenotypic effects of long-term Elam treatment on aging in C57BL/6 mice starting at 18 months of age. Methods: Mice were fed regular chow (RC diet) or a diet high in fat and sugar (HF diet) and treated with 3 mg/ kg of Elam or saline subcutaneously 5 days per week for 10 months. Physiological performance assessments were conducted at 28 months of age. Results: Elam improved the physical performance of males but not females, while in females Elam improved cognitive performance and enhanced the maintenance of body weight and fat mass. It also improved diastolic function in both males and females, but to a greater extent in males. The HF diet over 10 months had a negative effect on health span, as it increased body fat and decreased muscle strength and heart function, especially in females. Conclusions: Elam enhanced healthy aging and cardiac function in both male and female mice, although the specific effects on function differed between sexes. In females, the treatment led to better cognitive performance and maintenance of body composition, while in males, performance on a rotating rod was preserved. These overall observations have translational implications for considering additional studies using Elam in therapeutic or preventive approaches for aging and age-related diseases. Keywords: Aging, mitochondria, elamipretide, C57BL/6 mice, high fat and sugar diet
Potensi Learning Loss di SMA Negeri 4 Polewali Selama Pembelajaran Daring pada Masa Pandemi Covid-19
Authors: Rajib Muhammad , Puspita Sari Arlinda
Published: September 2022

Pandemi Covid-19 memberikan dampak yang sangat besar bagi kehidupan secara global, termasuk sektor pendidikan. Pola pengajaran mengalami perubahan yang memicu terjadinya learning loss di tingkat sekolah, tidak terkecuali di SMA Negeri 4 Polewali. Tujuan penelitian ini adalah untuk mengamati potensi learning loss yang terjadi di SMA Negeri 4 Polewali akibat pembelajaran daring. Penelitian menggunakan metode survey dengan membagikan angket kepada pendidik dan peserta didik di SMA Negeri 4 Polewali. Hasil pengamatan yang dilakukan menunjukkan adanya dampak pembelajaran yang dilakukan secara daring terhadap beberapa aspek proses belajar mengajar. Aspek yang dimaksud adalah 1) persiapan pembelajaran, 2) proses pembelajaran, 3) media atau alat bantu pembelajaran, dan 4) hasil pembelajaran. Keempat aspek ini mengalami perubahan secara signifikan yang menyebabkan terjadinya learning loss di SMA Negeri 4 Polewali
Розвиток гострого міокардиту як ускладнення COVID-19
Authors: Vyshnevska I. R. , Petyunina O. V.
Published: September 2022

The definite proofs of injury of SARS-CoV-2 infection on cardiovascular system are existing. Heart damage may be as primary without lung injury mentioned in literature «the heart phenotype», as secondary which is developed under lung injury and named «mixed cardio-pulmonary phenotype». The reason of prevalence of one or another phenotype is unknown but with confidence it can be confirmed that myocardial injury worsens the patient’s prognosis. The clinical case concernes the 19-year-old patient after new coronavirus infection COVID-19. The ilness courced in mild form, without lung injury. Myocarditis is clinically fixed after 2 weeks after coronavirus symptoms beginning. In our case repeated сonsistent hypertermia observed since 17 day of disease, the level of C-reactive proteine was elevated. The patient was evaluated after COVID-19. Echocardiography was done, it has been revealed segmentary and global strain decrease. Acute myocarditis was suggested and confirmed by magnetic resonance investigation (MRI) with gadolinium enhancement. Carvedilol 3,125 mg twice daily with dose titration to 25 mg twice, zophinapril 7,5 mg twice a day, spironolacton 25 mg daily, colchicin 0,5 mg twice daily, trimetazidiin 80 mg daily, phisical load restricition, rational nutrition were prescribed to the patient. Repeated MRI demonstrated resolution of acute myocarditis, only elements of light focal unischemic myocardial fibrosis were remained. Conclusion is that in patients with COVID-19 can develop myocarditis. The mechanism of development of this complication is unknown and needs further investigation.
Development of Youth Communities in the University Ecosystem: Resources, Projects, and Risks
Authors: Kiryakova A. V. , Kargapoltseva N. A. , Belonovskaya I. D. , Duzhnikov S. A.
Published: September 2022

The article explores the development of youth communities in the ecosystem of the Orenburg State University. The modern university is designed to create new conditions for the development of youth communities. The study of students’ creative challenges demonstrates a wide range of aspirations and needs, their uncertainty and spontaneity. The answer to creative challenges is timely competent navigation and organizational and pedagogical support of young people for integration into socially positive communities. A regional university can become a center, space and mobilizer for the development of youth communities. Youth communities are dynamically changing, their reality goes beyond educational and scientific activities. In this regard, the traditional scientist-oriented model of the university is being transformed into an ecosystem model, which equally reveals the areas of training, development and education. Modern education at the empirical level masters the ecosystem approach. The article aims at revealing resources, projects, and risks of youth communities development in the conditions of the formation of a regional university ecosystem. The subject of study is the structure, axiological, organizational and procedural foundations of the university ecosystem. The resources, methods and risks of developing modern youth communities also represent the perspective of the study of the humanities. Ecosystem resources of the Orenburg State University are presented in many aspects: axiology and pedagogical technologies, projects of the Priority 2030 program, integration with the Orenburg University (Educational) District Association, international educational cooperation with universities in Kazakhstan. The article identifies external and internal risks specific to the development of youth communities in the logic of “potential applicants – university ecosystem – potential employers” based on the study of accelerator programs, streams, online surveys.
Prevalence of Comorbid Dementia in Late-life Depression and Bipolar Disorder: A Retrospective Inpatient Study
Authors: Ochi Shinichiro , Mori Takaaki , Iga Jun-ichi , Ueno Shu-ichi
Published: September 2022

Background:

Dementia in patients with late-life mood disorders is clinically important.

Objective:

We aimed to investigate the prevalence of dementia in patients with late-life major depressive disorder (MDD) or bipolar disorder (BD) and to clarify the clinical characteristics associated with the diagnosis of dementia.

Methods:

The prevalence of dementia at hospital discharge and the clinical characteristics at hospitalization who are diagnosed with MDD or BD over 65 years of age, from the medical records of 684 patients who had been admitted from 2015 to 2020 were investigated.

Results:

A total of 66 patients with MDD ( n = 50) and BD ( n = 16) were analyzed. The prevalence of dementia was significantly higher in MDD than in BD (24.0% versus 0%; p = 0.026). The mean age at onset of MDD was significantly older in the MDD with dementia group than in the MDD without (76.9±6.3 years versus 62.2±14.0 years; p < 0.001). The rate of first depressive episode at this admission was significantly higher in the MDD with dementia group (91.7% versus 30.3%; p < 0.001). The diagnosis of dementia was significantly associated with lower scores for “insomnia early” ( p = 0.019) and higher scores for “insight” ( p = 0.049) on the 17-item Hamilton Depression Rating (HAMD-17) subscales and lower scores for “recall” ( p = 0.003) on the MMSE subscales.

Conclusion:

The older age of first onset of depression, “insomnia early”, “insight” and “recall” may be useful indicators for a diagnosis of dementia in late-life depression.
A bi-objective model for territorial design
Authors: Loranca Maria Beatriz Bernábe , Galván Carlos Guillen , Velázquez Rogelio González , Guzmán Gerardo Martínez , Canán Alberto Carrillo
Published: September 2022

The clustering of spatial-geographic units, zones or areas has been used to solve problems related to Territorial Design. Clustering adapts to the definition of territorial design for a specific problem, which demands spatial data processing under clustering schemes with topological requirements for the zones. For small sized instances, once the geographical compactness is attended to as an objective function, this problem has been solved by exact methods with an acceptable response time. However, for larger instances and due to the combinatory nature of this problem, the computational complexity increases and the use of approximated methods becomes a necessity, in such a way that when geographical compactness was the only cost function a couple of approximated methods were incorporated giving satisfactory results. A particular case of this kind of problems that has had our attention in recent years is the classification by partitioning of AGEBs (Basic Geographical Units by its initials in Spanish). Some work has been made related to the formation of compact groups of AGEBs, but additional re-strictions were often not considered. A very interesting and highly demanded application problem is to extend the compact clustering to form groups with for some of its descriptive variables. This problem translates to a multi-objective approach that has to pursue two objectives to attain a balance between them. At this point, to reach a set of non-dominated and non-comparable solutions, a method has been included that allows obtaining the Pareto front through the Hasse diagram, which implies proposing a mathematical programming model and the synthetic resulting between compactness and homogeneity.
FRAME: Federating Repositories of Accessible Materials for Higher Education A new collaborative framework
Authors: Kasdorf Bill
Published: September 2022

Most colleges and universities offer services at their institution for students with disabilities who cannot properly utilize the standard available resources. Often the student needing the remediated resource does not obtain it until the semester is up and running, putting them significantly behind the other students in the course. This paper discusses a multi-institutional project at the University of Virginia that was established to address this problem. With a four-year grant from The Andrew W. Mellon Foundation, the University initiated an effort to create a web-based infrastructure allowing Disability Services Offices to safely share remediated texts for qualified recipeints, in order to reduce their nationwide duplication of effort, and thereby make it possible for the staff in these offices to achieve better outcomes for students in higher education.
Supporting Open Science with frictionless publication workflows: The Tree of Life project at Wellcome Open Research
Authors: Grant Rebecca
Published: September 2022

This paper is based on a presentation delivered as part of the NISO Plus 2022 panel discussion titled “Open Science: catch phrase, or a better way of doing research?” that focused on the workflows of Open Science and opportunities for collaboration by stakeholders including publishers, repository infrastructure providers, and the wider research community.

While the aims and outputs of Open Science are well-defined, this paper explores the workflows that are necessary to support the production of “open scientific knowledge”, as defined by UNESCO. Producing research outputs as open scientific knowledge is an activity that is undertaken alongside traditional research practices and must be planned for from the beginning of the research process.

This paper explores the challenges and opportunities associated with Open Science workflows, focusing on an innovative new automated publishing pipeline on the Wellcome Open Research publishing platform.
Weight for It: Resistance Training Mitigates White Matter Hyperintensity-Related Disruption to Functional Networks in Older Females
Authors: Crockett Rachel A. , Hsu Chun Liang , Dao Elizabeth , Tam Roger , Eng Janice J. , Handy Todd C. , Liu-Ambrose Teresa
Published: September 2022

Background: White matter hyperintensities (WMH) are associated with impaired cognition and increased falls risk. Resistance training (RT) is a promising intervention to reduce WMH progression, improve executive functions, and reduce falls. However, the underlying neurobiological process by which RT improves executive functions and falls risk remain unclear. We hypothesized that: 1) RT reduces the level of WMH-related disruption to functional networks; and 2) reduced disruption to the sensorimotor and attention networks will be associated with improved executive function and reduced falls risk. Objective: Investigate the impact of 52 weeks of RT on WMH-related disruption to functional networks. Methods: Thirty-two older females (65–75 years) were included in this exploratory analysis of a 52-week randomized controlled trial. Participants received either twice-weekly RT or balance and tone training (control). We used lesion network mapping to assess changes in WMH-related disruption to the sensorimotor, dorsal attention, and ventral attention networks. Executive function was measured using the Stroop Colour-Word Test. Falls risk was assessed using the Physiological Profile Assessment (PPA) and the foam sway test. Results: RT significantly reduced the level of WMH-related disruption to the sensorimotor network (p = 0.012). Reduced disruption to the dorsal attention network was associated with improvements in Stroop performance (r = 0.527, p = 0.030). Reduced disruption to the ventral attention network was associated with reduced PPA score (r = 0.485, p = 0.049) Conclusion: RT may be a promising intervention to mitigate WMH-related disruption to the sensorimotor network. Additionally, reducing disruption to the dorsal and ventral attention networks may contribute to improved executive function and reduced falls risk respectively.
Cerebrospinal Fluid Sphingomyelins in Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation1
Authors: Morrow Autumn , Panyard Daniel J. , Deming Yuetiva K. , Jonaitis Erin , Dong Ruocheng , Vasiljevic Eva , Betthauser Tobey J. , Kollmorgen Gwendlyn , Suridjan Ivonne , Bayfield Anna , Van Hulle Carol A. , Zetterberg Henrik , Blennow Kaj , Carlsson Cynthia M. , Asthana Sanjay , Johnson Sterling C. , Engelman Corinne D.
Published: September 2022

Background: Sphingomyelin (SM) levels have been associated with Alzheimer’s disease (AD), but the association direction has been inconsistent and research on cerebrospinal fluid (CSF) SMs has been limited by sample size, breadth of SMs examined, and diversity of biomarkers available. Objective: Here, we seek to build on our understanding of the role of SM metabolites in AD by studying a broad range of CSF SMs and biomarkers of AD, neurodegeneration, and neuroinflammation. Methods: Leveraging two longitudinal AD cohorts with metabolome-wide CSF metabolomics data (n = 502), we analyzed the relationship between the levels of 12 CSF SMs, and AD diagnosis and biomarkers of pathology, neurodegeneration, and neuroinflammation using logistic, linear, and linear mixed effects models. Results: No SMs were significantly associated with AD diagnosis, mild cognitive impairment, or amyloid biomarkers. Phosphorylated tau, neurofilament light, α-synuclein, neurogranin, soluble triggering receptor expressed on myeloid cells 2, and chitinase-3-like-protein 1 were each significantly, positively associated with at least 5 of the SMs. Conclusion: The associations between SMs and biomarkers of neurodegeneration and neuroinflammation, but not biomarkers of amyloid or diagnosis of AD, point to SMs as potential biomarkers for neurodegeneration and neuroinflammation that may not be AD-specific.
Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia
Authors: Song Yang , Quan Meina , Li Tingting , Jia Jianping
Published: September 2022

Background: Although elevated levels of homocysteine (Hcy) are associated with cognitive impairment and dementia, the relevance of Hcy, vitamin B12, and folate levels to subtypes of dementia are still unknown. Objective: To investigate the changes of Hcy, vitamin B12, and folate levels in mild cognitive impairment (MCI) and subtypes of dementia including Alzheimer’s disease (AD), vascular dementia (VaD), frontotemporal dementia (FTD), and Lewy body dementia (LBD), and their relationships with cognitive function and magnetic resonance imaging (MRI) markers. Methods: We measured serum levels of Hcy, vitamin B12, and folate in 257 subjects. Each subject underwent cognitive function assessment and brain MRI test. The Fazekas and temporal lobe atrophy (MTA) visual rating scales were used to assess the degree of white matter hyperintensities and MTA, respectively. Results: Serum levels of Hcy was higher and vitamin B12 was lower in AD, VaD, FTD, and LBD groups than cognitively normal controls. No significant differences of folate levels were found among 6 groups. Hcy levels were positively correlated with MTA total score in AD (r = 0.448, p < 0.001). Vitamin B12 levels were positively correlated with MoCA in VaD (r = 0.497), and negatively correlated with MTA total score in AD (r = – 0.325) (ps < 0.05). Hyperhomocysteinemia may increase the risk of AD (OR = 2.744), VaD (OR = 3.600), and FTD (OR = 3.244) in the adjusted model (ps < 0.05). Conclusion: Hcy and vitamin B12 levels are associated with MTA in AD. Vitamin B12 levels are associated with general cognition in VaD. Hyperhomocysteinemia is a risk factor for not only AD and VaD but also FTD.
Inflammation-Related microRNAs-146a and -155 Are Upregulated in Mild Cognitive Impairment Subjects Among Older Age Population in Montenegro
Authors: Rovčanin Dragović Isidora , Popović Nataša , Ždralević Maša , Radulović Ljiljana , Vuković Tijana , Marzano Flaviana , Tullo Apollonia , Radunović Miodrag
Published: September 2022

Background: Pathological and clinical features of Alzheimer’s disease (AD) are in temporal discrepancy and currently accepted clinical tests provide the diagnosis decades after the initial pathophysiological events. In order to enable a more timely detection of AD, research efforts are directed to identification of biomarkers of the early symptomatic stage. Neuroinflammatory signaling pathways and inflammation-related microRNAs (miRNAs) could possibly have a crucial role in AD, making them promising potential biomarkers. Objective: We examined the expression of circulatory miRNAs with a documented role in AD pathophysiology: miR-29a/b, miR-101, miR-125b, miR-146a, and miR-155 in the plasma of AD patients (AD, n = 12), people with mild cognitive impairment (MCI, n = 9), and normocognitive group (CTRL, n = 18). We hypothesized that these miRNA expression levels could correlate with the level of participants’ cognitive decline. Methods: The study participants completed the standardized interview, neurological examination, neuropsychological assessment, and biochemical analyses. miRNA expression levels were assessed by RT-PCR. Results: Neurological and laboratory findings could not account for MCI, but miR-146a and -155 were upregulated in the MCI group compared to the control. miR-146a, known to mediate early neuroinflammatory AD events, was also upregulated in the MCI compared to AD group. ROC curve analysis for miRNA-146a showed 77.8% sensitivity and 94.4% specificity and 66.7% sensitivity and 88.9% specificity for miR-155. Conclusion: Determination of circulatory inflamma-miRs-146a and -155 expression, together with neuropsychological screening, could become a non-invasive tool for detecting individuals with an increased risk for AD, but research on a larger cohort is warranted.
Trust based COVID-19 vaccine distribution using blockchain technology
Authors: Anand R.
Published: September 2022

The COVID-19 outbreak has impacted huge number of individuals all around the world and has caused a great economic loss all over the world. Vaccination is most effective solution to prevent this disease. It helps in protecting the whole community. It improves the human immune system and fights against corona virus reducing the death rate. This paper deals with the different types of COVID-19 vaccine and their related distribution, it includes measures to ensure safe and secured distribution of the vaccine through block chain technology with the help of supply chain. Any malfunction in the chain is identified by the trust value of the function point method and the value of the Markov Chain.
Concept and strategy of SuperSUN: A new ultracold neutron converter
Authors: Chanel Estelle , Baudoin Simon , Baurand Marie-Hélène , Belkhier Nadir , Bourgeat-Lami Eric , Degenkolb Skyler , van der Grinten Maurits , Jentschel Michael , Joyet Victorien , Kreuz Michael , Lelièvre-Berna Eddy , Lucas Julio , Tonon Xavier , Zimmer Oliver
Published: September 2022

A new source of ultracold neutrons (UCNs), developed at the Institut Laue-Langevin (ILL) and named SuperSUN, is currently being commissioned. Its operational principle is the conversion of cold neutrons, delivered by ILL’s existing beam H523, to UCNs in a vessel filled with superfluid helium-4, wherein the neutron’s energy and momentum are transferred by inelastic scattering to phonons in the superfluid. The inverse Boltzmann-suppressed process is negligible at temperatures below 0.6 K, enabling long storage times and high in-situ UCN densities as demonstrated at the ILL for two prototype sources. These two prototypes are installed at secondary beams behind crystal monochromators, whereas a primary beam with a white cold spectrum illuminates the SuperSUN conversion volume. This provides not only higher intensity around the wavelength 0.89 nm where the dominant single-phonon process for UCN production takes place, but also a contribution to UCN production by multi-phonon processes. In the first phase of the project, material walls will trap the UCNs, while in the second phase an octupole magnet will generate a 2.1 T magnetic field at the edge of the conversion volume. For low-field-seeking UCNs, this field increases the trapping potential and reduces wall losses so that the accumulated UCNs are spin-polarized as a result. SuperSUN aims to deliver the highest possible UCN densities to external storage experiments, the first of which will be the PanEDM experiment measuring the neutron’s permanent electric dipole moment.
Risk Factors of Pulmonary Embolism in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A retrospective clinical study
Authors: Peng Ling , Wang An , Miao Ya-Fang , Xue Fei , Zhou Chao
Published: September 2022

BACKGROUND: The occurrence of pulmonary thromboembolism (PTE) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not rare, which would seriously affect the prognosis and cause high mortality of patients.

OBJECTIVE: To investigate the prevalence, risk factors, and clinical characteristics of AECOPD patients with pulmonary embolism (PE) complications in a tertiary care center, aiming to reduce the rate of missed diagnosis of PE in patients with AECOPD.

MATERIALS AND METHODS: We performed a retrospective analysis of patients admitted to our hospital with the first diagnosis of AECOPD from January 2015 to November 2019. Patients were divided into AECOPD and AECOPD +PE groups according to whether or not they had PE complications. The clinical data of the two groups were compared and multiple regression analysis was used to explore the risk factors.

RESULTS: From January 2015 to November 2019, a total of 636 AECOPD patients (aged 76.60±8.38 years, 529 males) were enrolled in this study. Of them, 7.4% (47/636) were diagnosed with PE. Clinical features including age, chest pain, dyspnea, hemoptysis, syncope, electrocardiogram (ECG), mMRC score, annual acute exacerbation times, history of thrombus, history of surgery within 6 weeks, prolonged immobility ≥3 days, wet rales, pleural effusion, asymmetrical lower extremity edema, history of stroke, pulmonary heart disease, pulmonary encephalopathy, hospitalization days, GOLD grade, total duration, PH, PaCO2, the level of plasma D-dimer and N-terminal pro-brain natriuretic peptide (NT-proBNP) were statistically significant between the two groups (P <0.05). Considering patients with PE as the dependent variables and statistically significant risk factors in the univariate analysis as independent variables, the logistic model analysis was performed. The results indicated that chest pain, syncope, premature ventricular contractions, prolonged immobility ≥3 days, history of stroke, pulmonary heart disease, pulmonary encephalopathy, hospitalization days, D-dimer levels, and acute exacerbation times were independent risk factors for AECOPD complicated with PE (P <0.05).

CONCLUSION: Patients hospitalized for AECOPD should have multi-slice spiral computed tomography pulmonary angiography (CTPA) to determine whether they present PE complications as soon as possible when combined with chest pain, pulmonary heart disease, prolonged immobility ≥3 days, plasma D-dimer levels higher, and the times of acute exacerbations has increased significantly in the last year.
Ansiedade, Depressão, Dor e Fadiga em Pacientes com Câncer de Mama que Realizaram Treinamento Combinado
Authors: Bringel Marília de Oliveira , Reis Andréa Dias , Aguiar Letícia Campos , Garcia João Batista Santos
Published: September 2022

Introdução: Apesar do aumento na sobrevida de pacientes com neoplasias de mama, muitas persistem com ansiedade, depressão, fadiga e dor mesmo após o tratamento anticancerígeno, fatores associados a uma pior qualidade de vida. Objetivo: Avaliar a influencia do treinamento combinado na ansiedade, depressão, dor e fadiga em pacientes com câncer de mama. Método: Ensaio controlado randomizado com 26 pacientes em quimioterapia, radioterapia ou acompanhamento clinico em um centro de referência em tratamento de câncer, com idade 30 a 59 anos, não praticantes de treinamento físico nos últimos três meses. O grupo experimental (GE) (n=13) foi submetido a três sessões por semana de treinamento aeróbico e resistido em 12 semanas, com duração de 60 minutos, e duas sessões de treinamento de flexibilidade por semana com duração de 20 segundos em três series. O grupo controle (GC) (n=13) realizou somente o tratamento hospitalar convencional. Todas as avaliações foram realizadas no tempo basal e após 12 semanas. Resultados: As pacientes do GE apresentaram redução significativa da ansiedade (p=0,0242), intensidade da dor (p=0,0290) e dimensão comportamental da fadiga (0,0033). Não foram observadas diferenças na depressão (p=0,0803), interferência da dor nas atividades habituais (p=0,0933) e dimensões afetiva (p=0,0583) e sensorial/cognitiva/emocional (p=0,5525) da fadiga. O GC permaneceu inalterado em todas as variáveis. Conclusão: O treinamento combinado, envolvendo exercícios aeróbios, de resistência e de flexibilidade durante 12 semanas, apresenta efeitos benéficos na ansiedade, fadiga e dor em pacientes com câncer de mama.
Ventajas de la cirugía robótica en Latinoamérica
Authors: Pulido Jiménez Angie Tatiana , Torres Socha Nydia Marcela , Ramírez Franco Laura Valentina
Published: September 2022

El impacto que ha tenido la robótica en Latinoamérica con los nuevos dispositivos robóticos, diseñados para el ámbito de la medicina, tiene un gran auge y aceptación debido a la innovación que presentan, ofrece muchos beneficios para la realización de procedimientos quirúrgicos no invasivos en relación con el procedimiento convencional, aunque se continúe observando que en conjunto ofrecerán tendencias quirúrgicas en las que se pretendan mejorar los diagnósticos posibles, tratamientos y pronósticos de recuperación del paciente. Con el uso de la robótica se implementan instrumentos quirúrgicos más usados, los cuales son modificados en forma y tamaño para un manejo adecuado en el paciente, para ofrecer mejores expectativas de vida, realizando un manejo apropiado a las posibles patologías de base que puedan presentan los pacientes de las especialidades más comunes donde se utiliza esta tecnología, como son: cirugía general, ginecología y urología. En su totalidad, estos dispositivos son traídos por asociaciones en el exterior, para así poder emplearlos en el área de la salud, generando un mantenimiento costoso, al igual que la formación que se debe brindar al personal médico designado para su manipulación, debido a que no están familiarizados con este conjunto de técnicas. Parte de la idoneidad de esta instrumentación corresponde a la posibilidad de realizar mejores movimientos, al imitar en alto grado los giros de muñeca que generalmente realiza el cirujano. También, ofrece una visión clara del sitio operatorio, eliminando los temblores, mejorando el acceso a lugares anatómicos de gran dificultad, a los cuales el cirujano no tiene acceso en un procedimiento realizado a cielo abierto. Las ventajas para los pacientes son: menos tiempo intraoperatorio, menor índice de infecciones, de inflamaciones, disminución del dolor al generar menor sangrado y una estadía hospitalaria corta.
Взаємодія систем і технологій навчання у забезпеченні ефективності формування професійної компетентності здобувачів вищої освіти в умовах медичного закладу
Authors: Рудий-Трипольський Владислав
Published: September 2022

У статті розкрито взаємодію систем і технологій навчання у забезпеченні ефективності формування професійної компетентності здобувачів вищої освіти в умовах медичного закладу. Визначено освітні системи та технології (технологія модульного підходу; технологія розвитку критичного мислення; технологія рефлексивного навчання; технологія проєктного навчання; технологія педагогічного супроводу) та показано, що розширення форм й технологій викладання фундаментальних дисциплін спрямоване на формування у здобувачів вищої освіти професійної мотивації для здійснення їх подальшої професійної діяльності, закріплення та конкретизацію отриманих знань і навичок. Наголошується, що вміле поєднання інноваційних методів та традиційних форм навчання, достатній науковий рівень та педагогічний досвід викладачів, їх уміння донести інформацію до здобувачів вищої освіти та достатня мотивація дозволяють досягти високих результатів у формуванні професійних та соціально-особистісних компетенцій у процесі навчання у медичних університетах, підготувати фахівців-медиків, які відповідають сучасним запитам охорони здоровʼя.
Ключові слова:системи навчання, технологій навчання, професійна компетентність, здобувачі вищої освіти, медичний заклад.
Соціально-психологічний супровід процесу реінтеграції особистості з різним груповим статусом в умовах сучасного соціуму
Authors: Завацька Наталія , Журба Микола , Блискун Олена , Завацький Юрій , Жигаренко Ігор
Published: September 2022

У статті розкрито особливості соціально-психологічного супроводу процесу реінтеграції особистості з різним груповим статусом в умовах сучасного соціуму.Здійснено концептуальне обгрунтування соціально-психологічних основ реінтеграції молодів умовах сучасного соціуму; поглиблено психологічні знання про феномен реінтеграції молодіз позицій системно-інтегративного та генетико-моделюючого підходів; розширено уявлення про соціально-психологічну специфіку оптимізації процесу реінтеграції молоді в умовах сучасного соціуму; визначено й обгрунтувано принципи, методи, прийоми та психотехнології системи соціально-психологічного забезпечення процесу реінтеграції молоді в умовах сучасного соціуму, наукову основу якої складають, зокрема, теорія соціалізації, когнітивно-поведінковий підхід; підходи в рамках скрипт-теорії; теорія активного соціально-психологічного навчання та ін. Розкрито можливості використання задіяного методичного інструментарію при проведенні системних досліджень феномену реінтеграції особистості; запропоновано інтегративно-інваріантні психотехнології системи соціально-психологічного забезпечення процесу реінтеграції молоді, спрямованих на оптимізацію цього процесу в умовах сучасного соціуму. Отримані наукові дані та вироблені на їх основі рекомендації можуть бути використані соціальними психологами, соціальними працівниками, соціологами, фахівцями та практиками, які займаються проблемами реінтеграції особистості в умовах сучасного соціуму; у психопрофілактичній роботі з молоддю щодо запобігання антисоціальної активності, зменшення девіацій у поведінці тощо. Розроблена система соціально-психологічного забезпечення процесу реінтеграції молоді може бути рекомендована для впровадження у закладах освіти, консультаційних Центрах, Центрах соціально-психологічної адаптації, Центрах медико-соціальної та соціально-психологічної допомоги з метою оптимізації процесу реінтеграції особистості в умовах сучасного соціуму. Матеріали дослідження можуть бути використані при підготовці освітньо-професійних та освітньо-наукових програм з оптимізації процесу реінтеграції особистості у соціум.
Ключові слова: особистість, реінтеграція, соціально-психологічне забезпечення процесу реінтеграції, груповий статус, сучасний соціум.
Внутрішня картина здоров’я як особистісний ресурс
Authors: Федчук Олександр
Published: September 2022

У статті автор розкриває сутність поняття «ресурсу» особистості, яке останнім часом у психологічному просторі часто використовується. Автор зазначає, що втрата внутрішніх та зовнішніх ресурсів спричиняє втрату суб'єктивного благополуччя, переживається як стан психологічного стресу, негативно позначається на стані здоров'я особистості. Серед достатньо вивчених ресурсів автор вказує на фізичні ресурси, зокрема, стан здоров’я та внутрішню картину здоров’я. Визначає мету статті як розкриття сутності фізичного ресурсу особистості через розуміння внутрішньої картини здоров’я, зокрема, ставлення до нього як цінності. Особистісна оцінка власного здоров’я досить значно впливає на поведінку хворого у процесі лікування захворювання, зокрема, існує прямопропорційний зв’язок між сприйманням особистого здоров’я та узгодженням з процесом лікування загалом, що звуть комплаентністю. Досліджуючи суб'єктивне сприйняття захворювання в роботах великої кількості дослідників було запропоновано безліч термінів, аналізуючи які автор стверджує, що внутрішня картина здоров’я є не лише результатом повсякденного життя індивіда, вона відображає в собі у вигляді символічних синтезів ті дозволи чи заборони, які можуть руйнувати або вдосконалювати, зберігати здоров'я особистості. Внутрішня картина здоров’я визначає вектор людської поведінки щодо ставлення до власного здоров’я й тіла, зокрема, орієнтує в імовірних перспективах її формування. Вона є одним з найбільш значимих елементів в комплексі поведінки особистості в ситуаціях, що становлять загрозу для здоров’я. Якщо у людини немає справжнього знання про здоров’я і необхідного життєвого досвіду, то є вірогідність того, що створиться невідповідна картина здоров’я, яка впливатиме на різні форми зародження невротичних реагувань на здоров’я.
Ключові слова: внутрішня картина здоров’я, внутрішній ресурс, психічне здоров’я, фізичні ресурси.
Analisis Performa Propeller Kaplan 4-55 dengan Pendekatan Computational Fluid Dynamic (CFD)
Authors: Pramesti Lely , Witjonarko Raden Dimas Endro , Aji Bayu Baskoro Aji
Published: September 2022

Propeller merupakan komponen yang sangat penting dalam sistem propulsi kapal. Performa propeller harus diperhatikan agar dapat tercapai kecepatan yang diinginkan oleh pemilik kapal. Performa yang dimaksud meliputi nilai thrust, torque dan propeller efficiency. Penelitian ini bertujuan untuk mengetahui nilai performa propeller Kaplan 4-55 dengan menggunakan pendekatan Computational Fluid Dynamic (CFD). Pengujian dilakukan dengan variasi putaran propeller 100 rpm, 300 rpm dan 500 rpm dan Va (velocity of advance) 1 m/s, 2 m/s, 3 m/s dan 4 m/s. Hasil dari analisis performa propeller Kaplan 4-55 didapatkan nilai thrust maksimum sebesar 255340,807 N pada putaran 500 rpm dengan Va sebesar 1 m/s, nilai torque maksimum 39274,329 Nm pada putaran 500 rpm dengan Va sebesar 1 m/s, sedangkan efficiency maksimum ditunjukkan pada variasi rpm 300 dengan Va 4 m/s yaitu sebesar 54,198%.
Faktor Penyebab Penyakit Diabetes Melitus dengan Metode Regresi Logistik
Authors: Hasibuan Nurul Khoiriah , Dur Sajaratud , Husein Ismail
Published: September 2022

Diabetes melitus adalah salah satu jenis penyakit yang tidak menular namun salah satu penyakit tertinggi di Indonesia. Indonesia menduduki peringkat ke empat dengan pasien diabetes melitus terbanyak. Tujuan dari penelitian ini adalah agar mengetahui faktor atau variabel mana yang berpengaruh signifikan terhadap diabetes melitus. Metode yang digunakan adalah regresi logistik, regresi logistik ialah suatu metode analisis statistika bertujuan untuk menggambarkan hubungan variabel dependen yang mempunyai dua/lebih kategori atau jenis dengan satu atau lebih variabel independen. Hasil penelitian ini diperoleh variabel olahraga mempunyai nilai signifikan sebesar 0,035. Variabel umur sebesar 0,030, variabel obesitas 0,669. Dan variabel hipertensi sebesar 0,035 serta variabel kolesterol sebesar 0,142. Sehingga dapat disimpulkan faktor penyebab diabetes melitus yang berpengaruh signifikan adalah umur, olahraga dan hipertensi, yang tidak berpengaruh signifikan adalah obesitas dan kolesterol. Probabilitas pasien terkena diabetes melitus adalah sebesar 0,997.
Global Pandemic and Its Effect on Papuan EFL Students’ Digital Concepts
Authors: Betaubun Martha , Anggawirya Arin Mantara
Published: September 2022

This study aims to reveal the influence of this pandemic on understanding digital concepts owned by native Papuan students who learn English, both indigenous and non-indigenous students. This study is categorized as a survey study. This study surveyed the EFL students’ digital concepts during global pandemic. To attain the data, researchers distributed questionnaires to respondents. The questionnaires were distributed to 228 students in eastern Indonesia. The data analysis technique used in this study is a quantitative descriptive analysis. The results of this study indicate that, in general, the understanding of digital concepts of EFL students in eastern Indonesia is still below the average value. In demographic mapping based on indigenous students and non-indigenous students, there are no significant differences. Even in some aspects, indigenous students in terms of knowledge. Finally, in comparing the duration of playing games as an alternative to relieve stress during the pandemic, those who do not play games tend to have a lower understanding than those who intensely play games for more than 4 hours. The research findings can be a catalyst for future studies digital concept in the realm of learning.
Artificial Intelligence for Neurosurgery : Current State and Future Directions
Authors: Noh Sung Hyun , Cho Pyung Goo , Kim Keung Nyun , Kim Sang Hyun , Shin Dong Ah
Published: September 2022

Artificial intelligence (AI) is a field of computer science that equips machines with human-like intelligence and enables them to learn, reason, and solve problems when presented with data in various formats. Neurosurgery is often at the forefront of innovative and disruptive technologies, which have similarly altered the course of acute and chronic diseases. In diagnostic imaging, such as X-rays, computed tomography, and magnetic resonance imaging, AI is used to analyze images. The use of robots in the field of neurosurgery is also increasing. In neurointensive care units, AI is used to analyze data and provide care to critically ill patients. Moreover, AI can be used to predict a patient’s prognosis. Several AI applications have already been introduced in the field of neurosurgery, and many more are expected in the near future. Ultimately, it is our responsibility to keep pace with this evolution to provide meaningful outcomes and personalize each patient’s care. Rather than blindly relying on AI in the future, neurosurgeons should gain a thorough understanding of it and use it to enhance their patient care.