bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolución del tratamiento ortopédico en dentición mixta con sistema trainer. Revisión de literatura
Authors: Tenecota Lema Mirian Alexandra , Ramos Montiel Ronald Roossevelt
Published: May 2023

Objetivo: El objetivo de este estudio fue conocer la evolución del tratamiento ortodóncico/ortopédico en dentición mixta con el sistema trainer .Materiales y métodos: Se realizó una revisión de la literatura encargada de recopilar información sobre, la evolución del tratamiento ortodóncico/ortopédico en dentición mixta con el sistema trainer para lo cual, se efectuó una búsqueda electrónica en diversas bases de datos como PubMed, Taylor and Francis, Pesquisa, Web of Science, Proquest, Scopus,  Dialnet, Google Académico, Researchgate y Ovid, aplicando los filtros de inclusión y exclusión. Resultados: Se realizó un primer cribado dejando 82 artículos; luego de esta selección, se eliminó la bibliografía duplicada, quedando 46 artículos, posteriormente, se verificaron todos los registros y se excluyeron 30 estudios que no cumplieron con los criterios de selección, lo que resultó en 16 artículos adecuados para esta revisión de literatura. Conclusiones:  Se emplearon diversos aparatos ortopédicos para la corrección de la maloclusión en pacientes pediátricos con el fin de encontrar nuevas formas para el tratamiento, planificación e intervención, por lo tanto, conocer cada uno de ellos facilitaría su aplicación con el objetivo de mejorar la calidad que se efectúa el tratamiento, los mismos que son posibles con aparatos prefabricados adecuados para cada paciente.
Educación en contexto de encierro y gestión penitenciaria en la resocialización de un centro penitenciario de Lima, 2022
Authors: Ramos Sosa Jeny
Published: May 2023

Esta investigación tuvo como objetivo determinar la influencia de la educación en contexto de encierro y la gestión penitenciaria en la resocialización de los internos de un establecimiento penitenciario de Lima, 2022. El estudio desarrollado correspondió al enfoque cuantitativo, tipo básica, diseño no experimental y un alcance explicativo; para ello, se utilizó una muestra de 159 internos varones de un establecimiento penitenciario de Lima, seleccionados mediante un muestreo probabilístico estratificado. Se utilizó como instrumentos de recolección de datos tres cuestionarios uno para cada variable, los mismos que fueron sometidos a procedimientos para demostrar su validez y confiabilidad. Se concluyó que, la educación en contexto de encierro y la gestión penitenciaria influyen de manera significativa (X2=210.886 y p=0.000) en la resocialización de los internos de un establecimiento penitenciario de Lima, generando una variabilidad de 82.7%.
Vigilancia Epidemiológica y la atención primaria en salud Post-Pandemia del Covid-19 en la Población vulnerable del Cantón Jipijapa
Authors: Delgado Bernal Doris Susana , Villacreses Veliz Elvira Geoconda , Acuña Acebo Mercedes Del Rosario , Parrales Choez Ana Joselyn
Published: May 2023

Ecuador ha emprendido importantes reformas en búsqueda de la universalidad y equidad, sin embargo, el sistema continúa fragmentado y no garantiza el acceso universal. La Vigilancia Epidemiológica y la Atención Primaria en Salud (APS) post-pandemia en la población más vulnerable del Cantón Jipijapa, son elementos esenciales para los entes reguladores de salud. El cantón, guiado por Ministerio de Salud Pública y otros sectores públicos y privados no gubernamentales y la sociedad civil, como un nuevo modelo de sistema de atención sanitario integrado. Esta investigacion tiene con objetivo describir los resultados obtenidos en la intervención del proyecto de vinculación con la sociedad como es ¨Vigilancia Epidemiológica y la Atención Primaria en Salud (APS) post-pandemia en la población más vulnerable del Cantón Jipijapa¨, La investigación fue no experimental, se utilizó el método descriptivo, de campo, aplicando un instrumento de recolección de información a 4066 viviendas de las parroquias urbanas y rurales del cantón Jipijapa, con la intervención activa de estudiantes de enfermería del sexto semestre y docentes de la Universidad Estatal del Sur de Manabí, guardando características éticas y metodológicas de rigor, con la finalidad de minimizar o destruir los reservorios de la reproducción de enfermedades vectoriales en diferentes áreas del cantón.
El Docente como Líder Inspirador de la Transformación Social
Authors: Taris Toalombo Fabián Vicente , Rea Hinojoza José Manuel , Quinatoa Chimborazo Segundo Gerardo , Hinojosa Manobanda Segundo German
Published: May 2023

El educador es reflejo de una sociedad en desarrollo de su conciencia cívica; por ello, el ser docente constituye una condición de vida, donde, toda acción acompaña su investidura; estigma, que realza la esencia de la nobleza humana tras concebir la inteligencia como un cimiento, de donde emergen muchas dimensiones y categorías de análisis, que le permite otorgar puntos de vida temporales a todos los que integran su comunidad escolar, promoviendo la necesidad de aprender para la vida, circunscrita en el valor de la identidad personal y realce social; pues, la complexión activa de la praxis, es un sistema relacional. De esta manera, al ejercer funciones gerenciales, es cardinal que el profesional de la docencia en su intento de pedagogizar la direccionalidad del aprendizaje, puede llegar a convertirlo en un sublime proceso de liderazgo, donde prevalezca lo organizacional desde su noción biótica de interacción. Esta vigencia en términos de identidad determina el camino multiexistencial, por cuanto ha de mover voluntades para ir redescubriendo al sujeto, tomando en cuenta su estructura, emociones y estimación en aras de motivar sus niveles de compromiso y responsabilidad encauzados a un liderazgo inspirador orientado  hacia la transformación social. En consecuencia, en el presente artículo se pretende describir el rol del docente desde su capacidad de "influir" favorablemente sobre sus estudiantes, siendo fiel ejemplo de inspiración para transformarlos socialmente,  lo cual es reflejo de las mejores prácticas profesionales y las experiencias exitosas de sus estudiantes para que con su ejemplo enseñe. En efecto, la importancia del liderazgo le permite al sistema educativo concatenar el profesionalismo, la formación, el trabajo, la entrega personal y la vocación, como dimensiones que acompañan "la inspiración" del buen maestro.
First record of Anthonomus sorbi Germar, 1821 (Coleoptera, Curculionidae) in Western Siberia with remarks of from other Siberian species
Authors: Legalov Andrei A. , Reshetnikov Sergei V.
Published: May 2023

The first record of Anthonomus sorbi Germar, 1821 (Curculionidae: Curculionina: Anthonomini) from Western Siberia (Novosibirsk Oblast and Krasnoyarsk Krai) is given. Distributions for A. sorbi, A. conspersus Desbrochers des Loges, 1868, A. pedicularis (Linnaeus, 1758), A. incurvus (Panzer, 1795) and A. phyllocola (Herbst, 1795) are given. A list of species of the genus Anthonomus from Siberia and the Russian Far East is compiled.
Observation of Vertically Ejected Plumes Generated by the Impact of Hollow Projectiles at Various Velocities
Authors: Kadono Toshihiko , Suzuki Ayako I. , Suetsugu Ryo , Maeda Ryusei , Watanabe Tatsuya , Miyaji Nina , Murayama Ayaka , Yoshida Fumi , Higuchi Arika , Shimaki Yuri , Hasegawa Sunao
Published: May 2023

Recently, impact experiments in space have been conducted in planetary exploration using hollow or internally structured projectiles. In laboratory experiments using hollow projectiles to investigate the differences in crater and ejecta from the case of solid projectiles, a plume perpendicular to the target surface has been observed, which has not been seen in conventional cratering experiments using solid projectiles. In this study, we conducted crater-formation experiments using hollow resin projectiles to understand the mechanism through which vertical plumes form in the case of hollow projectiles. We examined the generation of a vertical plume as a function of the impact velocity, v
imp. We found that (i) no vertical plume occurs at v
imp < 200 m s−1, (ii) the cases with or without a vertical plume are mixed at 200 < v
imp < 350 m s−1, (iii) no vertical plume occurs at 350 < v
imp < 800 m s−1, and (iv) a vertical plume occurs at 2 < v
imp < 3 km s−1. We qualitatively discussed the generation mechanism of the vertical plume using the results of recovered projectiles. Depending on v
imp, an empty hole in which there is no projectile materials can be opened along the central axis, resulting in the generation of a vertical plume.
Regard sur les campagnes chez les Osismes. Peuplement et activités dans le Léon et la vallée de l’Aulne du second âge du fer à la fin de l’Antiquité
Authors: Gandini Cristina
Published: May 2023

L’apparente discrétion des villae romaines a incité plusieurs auteurs à considérer que les campagnes de l’ouest de la Gaule Lyonnaise étaient peu occupées et faiblement intégrées sur le plan culturel. En réalité, l’organisation et l’évolution des systèmes de peuplement antiques sont encore mal perçues dans ces territoires. Malgré la progression très dynamique de l’archéologie régionale ces dernières décennies, les synthèses sur ces questions restent peu nombreuses. La présente contribution propose de revenir sur cette image dépréciée et tente d’apporter des éléments de compréhension sur les modes d’occupation du sol dans deux fenêtres d’étude situées dans la civitas des Osismes. Il s’agit d’observer la manière dont les Osismes se sont accommodés des pratiques promues par le modèle méditerranéen et de scruter leur attitude vis-à-vis de leurs traditions. Il ressort de cette étude tout le potentiel d’une recherche sur ce thème, malgré les limites d’une documentation hétéroclite et inégalement renseignée. Cette approche contribue aussi à réviser le schéma, encore bien ancré, qui soutient que les campagnes armoricaines ont subi une romanisation tardive, imparfaite et superficielle.
Les fermes gallo-romaines en Normandie orientale : genèse et caractéristiques de quelques exemples fouillés récemment
Authors: Lukas Dagmar , Adrian Yves-Marie
Published: May 2023

Plusieurs opérations archéologiques menées depuis une quinzaine d’années en Normandie orientale permettent d’enrichir nos connaissances sur les établissements ruraux gallo-romains. Un petit corpus de sept fermes, au statut économique plutôt modeste, offre ainsi de nombreuses données sur les rythmes de création et d’abandon, la morphologie et la variété architecturale, ainsi que sur certains aspects socio-économiques de ces exploitations agro-pastorales. Des sépultures à incinération mises au jour sur trois d’entre elles donnent également l’opportunité d’approcher les divers modes funéraires pratiqués dans ce secteur géographique.
International PhD students in France under COVID-19 Crisis
Authors: Ballatore Magali , Bertrand Jean-Baptiste
Published: May 2023

Depuis le début du xxi e siècle, la cartographie de la mobilité des doctorants a changé, elle s’est élargie et diversifiée ; elle s’accompagne de plus en plus de mouvements multicentriques, même si ces mouvements concernent encore majoritairement les Européens et les Américains. Depuis 2020, cependant, la crise sanitaire a rendu cette mobilité plus compliquée. Elle a pu être empêchée ou fortement limitée. Nous avons émis l’hypothèse que les jeunes chercheurs internationaux, peu étudiés malgré la forte internationalisation de la formation doctorale, ont été particulièrement touchés. Cet article propose donc d’étudier les conséquences de la récente crise sanitaire sur l’expérience des doctorants internationaux en France. Il s’appuie sur une enquête récente par questionnaire. L’analyse des données statistiques et le contenu des questions ouvertes montrent que les restrictions de voyage, les procédures d’isolement et la fermeture des frontières ont en quelque sorte modifié la nature de l’expérience doctorale internationale, augmenté les vulnérabilités, et changé les conditions de travail des jeunes chercheurs internationaux en France.
Towards a ‘care-sharing’ model? Multilateral adjustment strategies for post-pandemic students’ mobility in Europe
Authors: Gatti Tiziana , Maciejowska Dorota , Verzichelli Luca
Published: May 2023

L’article s’appuie sur les résultats de deux enquêtes sur les pratiques des universités du réseau du Groupe Coimbra en réponse à la crise du COVID-19. Nous développons d’abord un cadre théorique et soulevons quelques questions reliant la réaction à court terme face à l’épidémie à la dimension de la coopération à long terme pour protéger et améliorer la mobilité académique entre les universités.Après avoir analysé la variance entre les universités en termes de déclin de la mobilité des étudiants pendant la première vague de la pandémie, l’article évalue la capacité du réseau à prévenir la démotivation et la méfiance, en combinant les avantages des instruments ex ante de protection de la mobilité avec la mise en œuvre d’outils ad hoc de résolution des crises.La dernière section de l’article développe une interprétation basée sur la notion multidimensionnelle et multifonctionnelle de « partage des responsabilités ». Nous soutenons que les actions multilatérales peuvent renforcer une stratégie d’ajustement globale et préventive. Une telle stratégie, large et responsable, concourra à un retour rapide à des taux de mobilité élevés, activant en même temps des pratiques inclusives et innovantes et diffusant les valeurs de durabilité sociale et environnementale au sein de notre communauté d’apprenants.
« Deus est in luce »
Authors: Solignac Charlotte
Published: May 2023

L’hapax lu chez Bonaventure «  Deus est in luce  » se révèle avoir une racine scripturaire qui est la première épître de Jean. Cette affirmation a été peu commentée par les Pères et les docteurs de l’Église, et encore moins questionnée et résolue de façon systématique. Nous proposons de rappeler les principales mentions patristiques et médiévales de l’idée d’un Dieu inhérent à la lumière afin de montrer que sa signification est souvent superficielle et disparate. En effet, cette espèce de « photothéisme », « Dieu est dans la lumière », est-elle une affirmation de nature panthéistique ? Comment concilier une telle affirmation avec le refus chrétien du panthéisme ? Les arguments médiévaux réfutant le panthéisme étant insuffisants pour établir le sens valide de l’affirmation johannique, il faut élucider cet hapax par les développements sur l’ubiquité divine et l’inhérence de Dieu dans les choses, à savoir son être in re , pour tenter d’en déceler quelques sens valides.
Mechanical properties and brittleness of concrete made by combined fly ash, silica fume and nanosilica with ordinary Portland cement
Authors: Golewski Grzegorz Ludwik
Published: May 2023

This paper introduced a new concrete composites made by quaternary binder by partially replacing ordinary Portland cement (OPC) with different percentages of supplementary cementitious materials (SCMs). The motivation is to reduce our dependency on OPC to reduce CO2 emission and carbon foot print. As the main substitute for the OPC, siliceous fly ash was used (FA). Moreover, silica fume (SF) and nanosilica (nS) were also used. This study utilized the following contents of SCMs used: 5% of nS; 10% of SF; 0, 15, and 25% of FA. During examinations the main mechanical properties of concrete composites, i.e. compressive strength (fcm) and splitting tensile strength (fctm) were assed. The brittleness of these materials was also analysed. Based on the conducted studies, it was found that concrete composite based on quaternary blended cements, of series Mix3, has shown the best results in terms of good strength parameters, whereas the worst mechanical parameters were characterized by concrete of series Mix4. On the other hand, concrete including only SF and nS (Mix2 series) were characterized by the greatest brittleness. It was observed that fcm of concrete composites for series Mix2, Mix3, and Mix4 increase of 41%, 48%, and 31% respectively compared with the concrete without additives, i.e. series Mix1. In addition, fctm also increase of 39%, 47%, and 30%, respectively, for the three series mentioned above, compared with the control concrete. Concrete of series Mix3, with high mechanical properties and demonstrating the features of quasi-plastic material, i.e. having lower brittleness, can be used in concrete and reinforced concrete structures subjected mainly to dynamic and cyclic loads. Therefore, it can be used, in the construction of foundation structures for machines and other types of structures in which the above-mentioned loads are dominant.
Adaptive backstepping position tracking control of quadrotor unmanned aerial vehicle system
Authors: Song Xia , Shen Lihua , Chen Fuyang
Published: May 2023

In this work, an adaptive backstepping position tracking control using neural network (NN) approximation mechanism is proposed with respect to the translational system of quadrotor unmanned aerial vehicle (QUAV). Concerning the translational system of QUAV, on the one hand, it does not satisfy the matching condition and is an under-actuation dynamic system; on the other hand, it is with strong nonlinearity containing some uncertainty. To achieve the control objective, an intermediary control is introduced to handle the under-actuation problem, then the backstepping technique is combined with NN approximation strategy, which is employed to compensate the uncertainty of the system. Compared with traditional adaptive methods, the proposed adaptive NN position control of QUAV can alleviate the computation burden effectively, because it only trains a scalar adaptive parameter instead of the adaptive parameter vector or matrix. Finally, according to Lyapunov stability proof and computer simulation, it is proved that the control tasks can be accomplished.
Zermelo's navigation problem for some special surfaces of rotation
Authors: Li Yanlin , Laurian-Ioan Piscoran , Alqahtani Lamia Saeed , Alkhaldi Ali H. , Ali Akram
Published: May 2023

In this paper, we investigate Zermelo's navigation problem for some special rotation surfaces. In this respect, we find some Randers-type metrics for these rotation surfaces. Furthermore, we get the H-distortion for the metric induced by surfaces.
Secure keys data distribution based user-storage-transit server authentication process model using mathematical post-quantum cryptography methodology
Authors: Henge Santosh Kumar , Jayaraman Gitanjali , Sreedevi M , Rajakumar R , Rashid Mamoon , Alshamrani Sultan S. , Alnfiai Mrim M. , AlGhamdi Ahmed Saeed
Published: May 2023

The central remote servers are essential for storing and processing data for cloud computing evaluation. However, traditional systems need to improve their ability to provide technical data security solutions. Many data security challenges and complexities await technical solutions in today's fast-growing technology. These complexities will not be resolved by combining all secure encryption techniques. Quantum computing efficiently evolves composite algorithms, allowing for natural advances in cyber security, forensics, artificial intelligence, and machine learning-based complex systems. It also demonstrates solutions to many challenging problems in cloud computing security. This study proposes a user-storage-transit-server authentication process model based on secure keys data distribution and mathematical post-quantum cryptography methodology. The post-quantum cryptography mathematical algorithm is used in this study to involve the quantum computing-based distribution of security keys. It provides security scenarios and technical options for securing data in transit, storage, user, and server modes. Post-quantum cryptography has defined and included the mathematical algorithm in generating the distributed security key and the data in transit, on-storage, and on-editing. It has involved reversible computations on many different numbers by super positioning the qubits to provide quantum services and other product-based cloud-online access used to process the end-user's artificial intelligence-based hardware service components. This study will help researchers and industry experts prepare specific scenarios for synchronizing data with medicine, finance, engineering, and banking cloud servers. The proposed methodology is implemented with single-tenant, multi-tenant, and cloud-tenant-level servers and a database server. This model is designed for four enterprises with 245 users, and it employs integration parity rules that are implemented using salting techniques. The experimental scenario considers the plain text size ranging from 24 to 8248 for analyzing secure key data distribution, key generation, encryption, and decryption time variations. The key generation and encryption time variations are 2.3233 ms to 8.7277 ms at quantum-level 1 and 0.0355 ms to 1.8491 ms at quantum-level 2. The key generation and decryption time variations are 2.1533 ms to 19.4799 ms at quantum-level 1 and 0.0525 ms to 3.3513 ms at quantum-level 2.
Blockchain
Authors: Muthireddi Kalpana
Published: May 2023

This chapter looks at blockchain technology from a legal perspective and discusses the opportunities, risks, and challenges that surround the use of this technology. It adopts a three-pronged approach to discussing blockchain technology, how it can be leveraged, and the challenges that must be addressed before it can be adopted. The three areas of discussion are 1) legal and regulatory compliance issues; 2) the various business applications, possible risks, and how they are addressed, and 3) the possibilities for harnessing this technology for well-being and welfare of the general public.
Digital Entrepreneurship and Micro and Small Enterprises in the Time of the COVID-19 Pandemic in Mexico
Authors: Chiatchoua Cesaire
Published: May 2023

The objective of this research is to analyze some work areas of interest as a result of the COVID-19 pandemic such as content marketing and social networks, artificial intelligence, 3D printing, virtual reality, big data, devices through the voice, robotization, automation, and digital transformation of companies, electronic commerce, and digital leisure for the development of digital entrepreneurship with the aim of promoting self-employment of young people, mainly from Generation Z. A qualitative methodology with a cross-sectional and descriptive scope was used with secondary sources. The results show that technological tools are the new source for business development. Although Mexico is prepared for the implementation of businesses via the internet, it should be noted that there are still barriers such as bureaucracy, training, greater investment, ignorance, and resistance to change. It is urgent to develop collaborative public-private-academy strategies to strengthen institutions, infrastructure, and human skills focused on new technologies to guarantee decent employment.
Global Events to Enhance Tourism
Authors: Lakshmi Shree K.  , Ashok Kumar R.
Published: May 2023

Targeting tourist behavior at global events could be one of the interesting topics for business houses. Location Based Analytical - Business Intelligent (LBA-BIntelligent) frameworks predict targeted tourist behavior at global events. The organizing countries create new businesses and gain a competitive advantage from tourists. This framework streamlines marketing to the right people at the right time. This study focuses on implementing bagging and boosting ensemble approaches. These classifiers have been evaluated on various parameters such as accuracy, precision, recall, F-score, Kappa score, and ROC-AUC score. The classification results show that the bagging approach gives better results through all the evaluation metrics.
The Role of Institutions of Higher Education in Promoting the Development of Sustainable Green Energy Policies that Facilitate Climate Justice and Environmental Equality
Authors: Kaplan Mitchell Alan
Published: May 2023

The climate crisis has become one of the international community's most critically debated social issues of the modern era. Environmental impact studies have produced demographic data documenting the adverse effects of this devastating phenomenon on industrialized and third-world nations. Living in a world threatened by climate disasters has become a galvanizing force for social change. It has become a motivational force that has inspired thousands of individuals worldwide to organize into community coalitions focused on developing and implementing green energy policies supporting sustainable reforms that impact climate justice and environmental equality. President Biden's reinstatement of U.S. participation in the Paris Climate Accord in 2021 provides tangible evidence reaffirming U.S. commitment to shared responsibility for transitioning global energy production to renewable sources that protect the integrity of the natural environment and reduce the burden of social disparity that impacts the world's most vulnerable populations. This chapter analyzes how colleges and universities can play a vital role in social investment in research projects and educational programs supporting green energy solutions to climate change.
The Importance of Experiential Learning in Sustainable Tourism and Development Education and a Creative Drama-Based Course Proposal
Authors: Balyali Tuğçe Özoğul
Published: May 2023

Education is important in increasing individual and social awareness regading sustainable tourism and development. Sustainable tourism and development courses are included in the curriculum of different programs in the field of tourism. However, information on the subject is transferred theoretically. Considering the content of sustainable tourism and development issues, experiential learning methods and techniques should be used in terms of transforming the learned information into permanent behavior. In this section, first of all, the importance of experiential learning in sustainable tourism and development teaching is discussed, and the details of a creative drama-based course proposal are given. In addition, students' opinions on the course in which the creative drama method was applied are presented. This section is a guide on how to handle important issues, such as sustainable tourism and development through the creative drama method.
Reactive systemic vasculitis in the course of a coronavirus OC43 infection: a case report
Authors: Jacquet Benjamin , Curiale Vito , Mangeard Hélène , Ferrer Émilie , Chaillou Sylvie
Published: May 2023

This case report details a severe systemic failure following a coronavirus OC43 (HCoV-OC43) infection. A 78-year-old man, who had been vaccinated against SARS-CoV-2, was hospitalized for a flu-like infection and abdominal pain, revealing bilateral hemorrhagic adrenal infarctions with secondary adrenal failure. Imagery examinations showed adrenal necrosis and multiple ischemic cerebral strokes. A multiplex retro-transcriptase polymerase chain reaction (RT-PCR) became positive for HCoV-OC43. Cardio-vascular, infectious, and auto-immune exams were negative. A steroid medication finally allowed clinical improvement, and the diagnosis of reactional vasculitis was retained. An unknown pathogenicity of HCoV-OC43 is possible, considering that RT-PCR research is rarely made. The hypothesis of cross-reactions with SARS-CoV-2 antivaccine antibodies is also feasible. At last, the possible former virulence of HCoV-OC43 is being researched, in the event that this virus is connected to the 1889 Russian influenza pandemic. The development of multiplex RT-PCR would enable the study of other HCV-OC43 infections.
Type E Xeroderma Pigmentosum
Authors: Kumari Pallavi , Jain Sonia Pramod , Sonkusale Pratiksha , Deshmukh Abhay Vilas
Published: May 2023

Xeroderma pigmentosum (XP) is an inherited condition with an extreme sensitivity to ultraviolet radiations. This condition mostly affects the eyes and areas of skin exposed to the sun and the nervous system. Here, we report a rare type XP E present in siblings. A 24 year old married female came to the dermatology outpatient Department with chief complaints of multiple dark-colored raised lesions over the nose, cheeks, eyebrows, forehead with hypopigmented lesions over bilateral forearm since 10 years. Her 21-year-old younger brother had similar lesions over face since 8 years. Both had a history of bilateral cataract with no neurological abnormality. Based on history, clinical and histopathological examination the diagnosis of XP E type was made. As per our knowledge, very few cases of this rare variety of XP E in siblings have been reported. Hence, we report this rare XP E in siblings.
Diagnosis of Post Kala Azar Dermal Leishmaniasis in Nonendemic Areas
Authors: Rao Gandikota Raghurama , Kishore M Raja Ratna , Singh Ruchi , Haritha Kollipara
Published: May 2023

Leishmaniasis is a heterogeneous group of disease caused by protozoans of the genus Leishmania, transmitted by Phlebotomus sandflies. Human leishmaniasis is usually classified as visceral, cutaneous (localized, diffuse, disseminated), mucocutaneous, and post-kala-azar leishmaniasis. Post-kala-azar leishmaniasis is a sequel of visceral leishmaniasis (VL) caused by Leishmania donovani (LD) and seen in India, Bangladesh, Nepal, and Sudan. In India, it develops in 5%–15% of treated VL cases within 2–5 years. It is characterized by multiple papular, nodular, and pleomorphic lesions over the sun-exposed areas such as face, neck, and arms, without systemic manifestations. It mimics a wide range of dermatoses, particularly leprosy in endemic areas for both the diseases. Inadequate immune response (Th1 and Th2) to infection during and after the treatment of VL plays a role in the pathogenesis. It is thought to be a good reservoir of LD and plays an important role in the treatment of VL. Post-kala-azar dermal leishmaniasis (PKDL) is usually diagnosed by skin smears, immunological tests such as rK39, cutaneous leishmaniasis detection tests, and polymerase chain reaction. A combination of liposomal amphotericin B and miltefosine is the first line of treatment. PKDL is a forgotten clinical entity in the nonendemic areas. We report a case of PKDL in a 52-year-old male from Andhra Pradesh, a nonendemic area for leishmaniasis. This case was treated successfully with combination therapy, liposomal amphotericin B, and miltefosine.
Blaschkitis or Lichen Striatus
Authors: Pravin Pravin R , Salunke Tejaswini S , Kulkarni Vinay V , Patki Anil H
Published: May 2023

Blaschkitis is an uncommon inflammatory dermatosis of unknown etiology, usually affecting adults. It is characterized by unilateral linear pruritic eruptions along the Blaschko's lines, usually seen on the trunk. Here, we report a case of this rare disorder and have put forward an argument why it is different from lichen striatus.
Fetal Varicella Syndrome
Authors: Patokar Abhishek S , Holani Aditya R , Khatu Swapna , Chaudhari Nitin , Palaskar Nachiket
Published: May 2023

Fetal varicella syndrome (FVS) is an extremely rare condition of the newborn, characterized by cutaneous scars, limb defects, ocular, and central nervous system abnormalities. It follows maternal varicella infection during early pregnancy. We are reporting a 4-day-old female child who presented with a linear, depressed, erythematous, localized scarring over the right knee with hypoplasia of the right lower limb and malformed right great toe. Clinical presentation of her right foot was resembling congenital talipes equinovarus. Mother had a history of varicella during the first trimester of pregnancy. Ocular examination revealed subretinal hypopigmented exudation with scanty vitreous hemorrhage and tunica vasculosa lentis seen on indirect ophthalmoscopy in the right eye. Ultrasonic A/B scan of the right eye was suggestive of microphthalmia. We confirmed the diagnosis of FVS based on characteristic history, clinical features, and varicella-zoster IgG antibodies were positive.
Leukemia Cutis
Authors: Chitapur Umamaheshwari G , Athanikar Sharathchandra B , Panchagavi Asha B , Naveen K N , Athanikar Vidisha S
Published: May 2023

Leukemia cutis is an infiltration of the skin by myeloid or lymphoid neoplastic leukocytes resulting in clinically identifiable cutaneous lesions. It may follow, precede, or occur concomitantly with the diagnosis of systemic leukemia. A 55-year-old female patient was a known case of acute myeloid leukemia (AML) and was on palliative chemotherapy. She presented to the Department of Dermatology with sudden-onset nodules over the chest and abdomen which were multiple, nontender and firm in consistency. Histopathological examination from the nodule over the abdomen suggested leukemic infiltration of the skin and repeat hemogram showed reappearance of blast cells in the peripheral smear, consistent with a diagnosis of leukemia cutis with relapsed AML. The case has been reported for its rarity and poor prognosis associated with its presentation.
Dermatological Manifestations in the Elderly: A Descriptive Cross-Sectional Study
Authors: Aithal Vijay , Chacko Ancy , Prathibha JP
Published: May 2023

Background:

Aging is mainly due to chronic interaction between extrinsic and intrinsic factors. The elderly population is highly vulnerable to skin diseases due to immunosenescence, polypharmacy, chronic exposure to ultraviolet radiation, and inadequate nutrition.

Objectives:

(1) To estimate the prevalence of dermatological manifestation in the elderly population. (2) Clinico-pathological correlation of the cutaneous tumors seen in the study population.

Materials and Methods:

A total of 300 elderly patients (above 60 years) who attended the outpatient department and inpatients of a tertiary care hospital, were recruited for the study, during a 1 year period (2019–2020). Patient demographics, brief history, and clinical examination were done. Relevant laboratory investigations, including side laboratory procedures and skin biopsy were done when necessary.

Results:

Most of the patients were between 65 and 70 years, 175 were male and 125 were female. Type-2 diabetes mellitus and hypertension had equal incidence. Dermatophyte infection was the most common presentation, followed by eczema, papulosquamous, and auto-immune bullous disorders. Nail changes were observed in 50% of the patients. Among those who had drug reactions, 50% had drug hypersensitivity syndrome to anti-tubercular drugs. Malignancies, including basal cell carcinoma, were not uncommon. Alcohol, sunlight, and the male gender were associated with an increased risk of wrinkling.

Conclusion:

Health education programs regarding skin disorders and preventive measures in the geriatric population will help improve their quality of life.
A Study of Vitamin D Receptor Gene Polymorphisms and Serum 25-Hydroxyvitamin D Levels in Vitiligo Patients and Controls
Authors: Noronha Tonita M , Girisha Banavasi Shanmukha , Kumari Suchetha , Shetty Shilpa S , Sampath Muthtamil
Published: May 2023

Background:

Vitiligo is a common pigmentary disorder affecting 0.1%–2% of the global population. Recently, interest has evoked in the role of Vitamin D in decreasing the risk of several chronic diseases. Little is known about the genetics of vitiligo. This study was conducted to investigate whether Vitamin D receptor (VDR) polymorphisms could be the susceptibility markers for vitiligo.

Objectives:

(i) To evaluate the potential association between VDR polymorphisms and vitiligo susceptibility and (ii) To estimate the serum levels of 25–hydroxyvitamin D in case and control groups.

Materials and Methods:

This study included 34 participants (17 with vitiligo and 17 age-and gender-matched healthy controls). After a written informed consent, a detailed history and examination was done. Serum 25(OH)D levels were measured using the enzyme-linked immunosorbent assay kit. Genomic DNA was extracted from the peripheral blood. The VDR polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Fok1, Bsm1, Apa1, and Taq1 restriction enzymes were used to determine the genotypes of the respective polymorphisms.

Results:

Nonsegmental vitiligo was the most common type of vitiligo seen in 14 (82.4%) cases. The mean serum Vitamin D level in cases was 35.64 ± 15.68 ng/ml and in controls was 37.00 ± 16.45 (P = 0.81). There was no significant difference in the distribution of VDR polymorphisms between the case and control groups.

Conclusion:

In our study, no significant difference was observed in the distribution of Fok1, Bsm1, Apa1, and Taq1 VDR polymorphisms between the case and control groups. However, we observed a significant association between the Fok1 polymorphism and serum 25(OH) Vitamin D levels in vitiligo patients studied.
Calcinosis Cutis in Chronic Myeloid Leukemia
Authors: Inamadar Arun C , Lingaiah Anusha , Janagond Ajit B
Published: May 2023

Calcinosis cutis is a rare condition of calcium deposition in skin and subcutaneous tissue. Multiple underlying diseases have been implicated for calcification, the pathogenesis of which is poorly understood. We report a case of calcinosis cutis secondary to chronic myeloid leukemia. The case is being reported for its rarity of association.
An Unusual Paraneoplastic Manifestation of Adenocarcinoma Lung
Authors: Jacob Niji Sara , Indra C Kanmani , Nasrin M I , Aswathi P Raj
Published: May 2023

Tripe palms (TP) are the rare paraneoplastic manifestation with the thickened palms and pronounced dermatoglyphics. In cancer patients with mere TP, the most occurring malignancy is pulmonary carcinoma. Although it precedes a malignancy, it may arise at any point in the course of the disease. Here, we present a patient who came with complaints of thickened blackish discoloration of palms and soles for 3 weeks and a clinical diagnosis of TP was made. He had concomitant adenocarcinoma lung TNM stage IB diagnosed 5 months back. Thus, he was diagnosed with TP secondary to adenocarcinoma lung. Although TP precede internal malignancy we report this case as TP occurred after the diagnosis of adenocarcinoma of the lung was made.
A Study of Platelet-Rich Plasma in the Management of Chronic Nonhealing Ulcers
Authors: Rao Angoori Gnaneshwar , Fathima Kousar
Published: May 2023

Background:

Chronic nonhealing ulcers run protracted course and require prolonged rest and complete avoidance of pressure, antibiotics, and antiseptic dressing, which at times may not yield satisfactory results. Local application of certain growth factors is known to promote healing in these cases.

Objectives:

To study the efficacy of autologous platelet-rich plasma in the management of chronic nonhealing ulcers.

Materials and Methods:

Z-statistics and Chi-square tests were used in the statistical analysis of this study. The study consisted of 30 patients of chronic nonhealing ulcers who presented to the dermatology department. Patients aged between 18 and 65 years of both sexes presenting with noninfective ulcer of duration of more than 6 weeks, treated or untreated and who have normal complete blood picture, were recruited. Diabetic patients with uncontrolled sugar levels were excluded. Ulcer examination was carried out as per clock-face method. Examination of peripheral pulses, nerves, and sensations was carried out. Routine hematological and biochemical investigations were done. Platelet-rich plasma was prepared from patient's blood, and 1.5–2 ml was injected at the healing margins using insulin syringe (26 G) after cleaning. Procedure was repeated once weekly for 6 weeks, and the ulcer healing was assessed.

Results:

Of the 30 cases, 21 (70%) were male and 9 (30%) were female, with a male-to-female ratio of 2.3:1. A maximum number of cases were in the fifth decade (33.3%). Trophic ulcers (TUs) due to leprosy contributed to 30 (88.23%), venous ulcers (VUs) 2 (5.88%), and diabetic ulcers 2 (5.88%). Improvement in area of TUs due to leprosy was 92.5%, in VUs 88.45%, and in diabetic ulcer 98.02% at the end of 6 weeks of platelet-rich plasma therapy.

Conclusion:

Platelet-rich plasma is an easily obtainable blood derivative and is a safe and potentially reasonable adjunct in the treatment of chronic nonhealing ulcers with advantage of no concern of immune reactions or cross-reactions or toxicity. It not only promotes healing but also prevents amputation necessitated by complications due to chronic ulcers.
Adult-Onset Linear Verrucous Epidermal Nevus in an Indian Male
Authors: Sudhir Nayak UK , Shenoi Shrutakirthi D , Singh Rupika , Pai Kanthilatha
Published: May 2023

Verrucous epidermal nevus is the most common form of epidermal nevi with usual onset at birth or early life. Adult onset is rare, and we report a case of verrucous epidermal nevi with onset in the fourth decade, dermatoscopy and histopathology of which were consistent with verrucous epidermal nevi.
Pemphigus Herpetiformis with Atypical Features
Authors: Arora Sukriti , Rao Raghavendra
Published: May 2023

Pemphigus herpetiformis (PH) is considered as an uncommon and mild variant of pemphigus. Here, we report the case of a 34-year-old woman who presented with intensely pruritic, annular crusted lesions with vesicles arranged in the periphery over the abdomen, back, and scalp. Cutaneous features were consistent with the clinical diagnosis of PH. However, she had certain unusual clinicoimmunopathological features. She also had oral erosions, which is a rare finding in this variant of pemphigus. The results of histopathological examination and enzyme-linked immunosorbent assay were also in line with the diagnosis of pemphigus vulgaris. She responded well to dapsone with significant objective and subjective improvement in 1-week follow-up.
Impact of COVID-19 on Dermatology Practice
Authors: Janagond Ajit B , Ratan Vartika R , Potthuri Indira , Pandit Vishalakshi S , Inamadar Arun C
Published: May 2023

Background:

The sudden outbreak of novel coronavirus has caused confusion, anxiety, and fear not only among the general public but also the health-care system. Considering widespread effects of the disease spilling into all aspects of life in general population and health-care workers alike, we conducted a study regarding the impact of coronavirus disease 2019 (COVID-19) on the functioning of the department of dermatology at a tertiary care hospital during the period of lockdown.

Objective:

We aimed to study the impact of COVID-19 infection and lockdown due to pandemic on practice of dermatology and workings in the outpatient department (OPD) at a tertiary care center.

Materials and Methods:

A cross-sectional, observational study was conducted on patients attending the dermatology OPD at a tertiary care center from April 11, 2020, to May 31, 2020. Patients were interviewed on the basis of a simple questionnaire seeking demographic details, complaints, diagnosis, history, and duration of treatment. Data obtained were recorded as numbers and percentages.

Results:

A total of 1022 individuals participated in the study with 620 (60.6%) males and 402 (39.33%) females. Among them, 625 (61.15%) were localities and 395 (38.64%) were from surrounding rural areas. The age of patients ranged from 6 months to 94 years, and majority were farmers. Eight hundred and twenty-nine (81.1%) were educated and 146 (14.2%) were illiterates. Six hundred and ninety-seven (68.1%) of the participants were new and 325 (31.8%) follow-up cases. Dermatophytosis 194 (27.8%) and psoriasis 15 (4.6%) were the most common diagnoses among new and old cases, respectively.

Conclusion:

A significant reduction was observed in the number of patients visiting the department seeking treatment. The pandemic necessitated various modifications in the patient examination and management protocols.
Immunohistochemical Demonstration of Interleukin-17 Positivity in Skin Biopsy Specimens of Patients with Chronic Plaque Psoriasis and its Correlation with Severity of Psoriasis and Associated Metabolic Syndrome and Cardiovascular Changes
Authors: Suparna Madivalara Yallappa , Shanmugam Reddy Praveen Kumar , Sumathy Tharayil Kunneth , Mysorekar Vijaya V
Published: May 2023

Background:

Psoriasis is a chronic inflammatory disease which can be associated with metabolic syndrome and cardiovascular abnormalities.

Objectives:

The aim and objective of the study are to demonstrate interleukin-17 (IL-7) positivity in histopathological sections of psoriatic plaques and to correlate with metabolic syndrome and cardiovascular changes.

Materials and Methods:

Forty-seven patients with chronic plaque psoriasis with body surface area >10% and psoriasis area and severity index (PASI) score >12, in whom skin biopsy showed munro's microabscesses, were evaluated for IL-17 positivity (intensity and proportion) with associated metabolic syndrome according to the National Cholesterol Education Program adult treatment panel III criteria and cardiovascular comorbidities. A co-relation with PASI score was made. IL-17 intensity and proportion were graded with a score ranging from 0 to 3. IBM SPSS version 16.0 was used for statistical analysis and independent t-test and Chi-square test were used for proportion.

Results:

The mean age of patients was 43 years. A total of 15 (31.9%) female and 32 (68.1%) male patients were enrolled. The mean PASI score was 21.6. Metabolic syndrome was seen in 31 (65.96%) patients. There was statistically significant association with raised diastolic blood pressure in patients with metabolic syndrome (P = 0.042). The total number of patients with IL-17 positivity with metabolic syndrome was 21 (63.6%). Of these, 9 (42.9%) cases showed IL-17 positivity in the munro's microabscess, 14 (66.7%) cases in the rest of the epidermis, and 18 (85.7%) cases in the dermis.

Conclusion:

In our study, there was no significant difference in IL-7 positivity between patients with or without metabolic syndrome. Further studies need to be done with large sample size to confirm the significance.
Cutaneous Emperipolesis: Rosai–Dorfman Disease – An Uncommon Entity
Authors: Kumar MB Shashi , Somaiah Savitha A , Mohan Murali , Vittal Rakshith
Published: May 2023

Rosai–Dorfman disease (RDD) is a rare, benign idiopathic, non-Langerhans cell histiocytosis. The most common presentation is massive bilateral painless lymphadenopathy with fever and weight loss. Approximately 40% of patients with RDD have extranodal involvement. The cutaneous involvement is the most common extranodal manifestation comprising 11% of RDD, but only 3% presents as pure cutaneous disease (CRDD). A 55-year-old male presented with a painless swelling over the neck in the midline of 2 months duration. On examination, a firm nodular lesion measuring 1 cm × 1 cm was located on the midline of the neck. Excision biopsy was done with a differential diagnosis of calcified cyst. Histopathological examination showed emperipolesis, and immunohistochemistry was positive for S 100 and cluster of differentiation (CD) 68 and negative for CD1a confirming a diagnosis of RDD. All systemic, biochemical, and radiological examinations were unremarkable. There was no further local recurrence after 1 year of follow-up.