bluuebunny/crossref_metadata_2025 huggingface dataset:
РОЛЬ МЕТФОРМІНУ У ЦЕНТРАЛЬНІЙ ТА ПЕРИФЕРИЧНІЙ НЕРВОВІЙ РЕГЕНЕРАЦІЇ
Authors: Жердьова Надія , Степура Олена , Древицька Тетяна , Костицька Ірина
Published: June 2023

В статі наведені дані щодо профілактики та лікування таких ускладнень, як когнітивні порушення та діабетична периферична нейропатія (ДПН), у пацієнтів з вперше виявленим цукровим діабетом (ЦД) 2 типу.
Метою дослідження було визначити частоту виявлення діабетичної периферичної нейропатії та когнітивних порушень у пацієнтів з вперше виявленим цукровим діабетом 2 типу та оцінити вплив метформіну на центральну та периферичну нервову регенерацію шляхом визначення рівня мРНК гена транспортеру SLC2A1 та гена BDNF.
Матеріали та методи. У дослідження було включено 38 пацієнтів із вперше виявленим ЦД 2 типу (40 жінок та 17 чоловіків) та 10 осіб контрольної групи. Всі пацієнти отримували в якості цукрознижувальної терапії метформін (глюкофаж ХR або діаформін SR). Середній вік хворих становив 59,76±1,67 роки, індекс маси тіла (ІМТ) – 34,27±0,97 кг/м2, середній рівень глікованого гемоглобіну – 8,12±0,22%. Перед початком дослідження та через 3 місяці вимірювали наявність нейропатії, стан когнітивних функцій, рівень мРНК гена транспортеру SLC2A1 та гена BDNF.
Результати. Пацієнти з вперше виявленим ЦД 2 типу мали вірогідно вищі показники ІМТ, рівня глікемії натще та глікованого гемоглобіну, нижчі рівні BDNF та SLC2A1 відносно контрольної групи. Під час обстеження стану когнітивних функцій визначили, що порушення функції пам’яті виявлено у 26,3% пацієнтів, швидкості обробки інформації – у 97,4%, виконавчих здібностей – у 57,9% обстежених осіб. За шкалою Торонто наявність периферичної діабетичної нейропатії виявлено у 68,5% пацієнтів. Після 3-місячного курсу лікування метформіном стан пам’яті у хворих нормалізувався та вдвічі збільшився відсоток осіб з відсутністю ДПН. Даний позитивний ефект може бути наслідком підвищення модулятора регенерації аксонів, зокрема BDNF, та вірогідного збільшення SLC2A1, який є ключовим регулятором транспорту глюкози в головний мозок через гемато-енцефалічний бар’єр. Висновок. Метформін статистично значуще покращував функцію пам’яті, виконавчих здібностей та зменшував прояви периферичної нейропатії, а також підвищував експресію BDNF та SLC2A1 через 3 місяці від початку лікування у осіб із вперше виявленим цукровим діабетом 2 типу, що в подальшому забезпечить комунікацію з лікарем, високу комплаєнтність у лікуванні та знизить ризик розвитку синдрому діабетичної стопи в майбутньому.
ПРОФІЛАКТИКА ТА КОРЕКЦІЯ ТИРЕОЇДНОЇ ДИСФУНКЦІЇ У ПІДЛІТКІВ ІЗ ЦУКРОВИМ ДІАБЕТОМ 1 ТИПУ НА ЕТАПАХ СТАТЕВОГО ДОЗРІВАННЯ
Authors: Турчина Світлана , Костенко Тетяна , Нікітіна Лариса , Вародова Ольга , Косовцова Ганна , Чумак Світлана , Шушляпіна Олена , Філіппова Неоніла , Левчук Людмила , Юдченко Ольга
Published: June 2023

Мета дослідження – удосконалити методи профілактики та лікування порушень функціонального стану гіпофізарно-тиреоїдної системи у підлітків, хворих на цукровий діабет 1 типу (ЦД1).
Матеріали та методи. Обстежено 114 пацієнтів із ЦД1 у віці 9-16 років (основна група) та 149 практично здорових однолітків (група порівняння). У всіх підлітків у сироватці крові імуноферментним методом визначено рівень тиреотропіну (ТТГ), вільних фракцій тиреоїдних гормонів (fT4 і fT3) та розраховано їх співвідношення (fT3/fT4 та ТТГ/fТ4). Аналіз отриманих показників проведено з урахуванням рівня статевого розвитку підлітків.
Результати обстеження об’єднано в електронний банк даних, математична обробка яких була проведена за допомогою пакетів програм «SPSS Statistics 17,0», «Microsoft Excel-2007». Критичний рівень значущості для перевірки статистичних гіпотез приймався рівним 0,05.
Результати. У підлітків обох груп на початку статевого дозрівання відбувається збільшення рівня ТТГ на тлі зменшення рівня fТ4 та збільшення співвідношення ТТГ/fТ4.  Показники співвідношень ТТГ/fТ4 та fТ3/fТ4 були вірогідно більшими у хворих на ЦД1, ніж в групі порівняння.
При індивідуальному аналізі встановлено, що ознаки тиреоїдной недостатності найчастіше визначали в період раннього пубертату серед підлітків обох груп (60,0% серед хворих на ЦД1 та 43,9% – в групі порівняння, p<0,05). На всіх етапах статевого дозрівання частота пацієнтів із гіпотиреозом була вірогідно більшою серед підлітків із ЦД1, ніж в групі порівняння (препубертат:16,0% проти 6,6%, p<0,05, ранній пубертат: 23,5% проти 0%, p<0,05, власно пубертат: 8,9% проти 2,9%, p<0,05). Обґрунтовано включення до схеми лікування препаратів калію йодиду (препарат ЙодомаринÒ 100 або препарат ЙодомаринÒ 200) та левотироксину (L-Тироксин Берлін-Хемі) при профілактики та лікування тиреоїдної дисфункції.
Висновки. У підлітків із ЦД1 вірогідно збільшується відсоток хворих, які мають ознаки тиреоїдної дисфункції завдяки підвищенню рівня ТТГ на тлі зменшення показників fТ4 та збільшення fТ3. Найчастіше ознаки тиреоїдної недостатності діагностують в період раннього пубертату. Профілактика та корекція тиреоїдної дисфункції є обов'язковою складовою реабілітаційної програми дітей та підлітків із цукровим діабетом 1 типу.
ОСОБЛИВОСТІ АНТИОКСИДАНТНОГО СТАТУСУ В СТРУКТУРАХ ГОЛОВНОГО МОЗКУ ЩУРІВ РІЗНОГО ВІКУ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОЇ ГІПЕРТИРОКСИНЕМІЇ
Authors: Войченко Ярослав , Родинський Олександр , Гузь Людмила
Published: June 2023

Метою даної роботи був аналіз нейрохімічних особливостей компонентного складу антиоксидантної системи у структурах головного мозку за умов експериментальної гіпертироксинемії, що формуються під несприятливим впливом факторів тривожності.
Матеріали та методи. Дослідження проведено на щурах лінії Wistar (n=50). Тварини були представлені двома віковими групами: 100-110 днів (щури юного віку), вагою 90-270 г, 7-8 місяців (щури середнього віку), вагою 210-340 г. Кожна вікова група тварин була розподілена на інтактних (контроль) та дослідних (гіпертироксинемія). Експериментальну гіпертироксинемію моделювали шляхом додавання у визначений час (9:00 ранку) із однаковою порцією їжі гомогенізованих таблеток L-тироксину (20 мкг/добу, “Berlin-Chemіe AG”, Німеччина). На 14-й день у тварин реєстрували гіпертироксинемію із показником тироксину в периферичній крові вище ніж 10 мкг/дл (результати верифікували імуноферментно за використанням тест-системи Humarlander). Після проведення поведінкових тестів відбирали щурів для визначення та оцінки біохімічних показників (каталаза та глутатіонпероксидази) у корі, стовбурі та гіпокампі головного мозку за допомогою спектрофотометричних методів.
Результати та висновки. Встановлено, що експериментальна гіпертироксинемія на тлі стану тривожності викликає суттєві зміни активності антиоксидантних ферментів у корі, стовбурі та гіпокампі головного мозку білих щурів різного віку. Фіксуються вікові зміни активності антиоксидантних компонентів, які відбуваються протягом дозрівання нервової системи. При аналізі біохімічних особливостей ферментативної активності у головному мозку підтверджується віковий антиоксидантний ефект за участю глутатіонпероксидази у щурів середнього віку. Обґрунтовано необхідність проведення подальших досліджень, спрямованих на визначення патологічного впливу оксидативного стресу за умов гіпертиреозу та стану тривожності на метаболічний статус ЦНС на різних вікових етапах.
КОНТРОВЕРСІЙНІ ПИТАННЯ ЩОДО КОМОРБІДНОЇ ПАТОЛОГІЇ: ЗАХВОРЮВАННЯ ПЕЧІНКИ ТА ЩИТОВИДНОЇ ЗАЛОЗИ (огляд літератури)
Authors: Мельниківська Наталя , Кудря Марія
Published: June 2023

Стаття є оглядом літератури щодо коморбідної патології печінки та щитовидної залози. Наведено статистичні дані поширення такого захворювання сучасного суспільства, як неалкогольна жирова хвороба печінки (НАЖХП). Розглянуто механізми розвитку НАЖХП, які обумовлені дисфункцією мітохондрій, розладами ендоплазматичного ретикулума та окислювальним стресом, утворенням активних форм кисню та секрецією запальних цитокінів. Описано патофізіологічний зв’язок НАЖХП та гіпотиреозу, що полягає у змінах рівня цитокінів, маркерів окислювального стресу та перекисного окиснення ліпідів, порушеннях гомеостазу селену, розладах ліпідного метаболізму. Проведено аналіз багатофакторних популяційних досліджень останніх років щодо асоціації НАЖХП та гіпотиреозу.
Surgical Tips for Improving Success Rate of Deep Anterior Lamellar Keratoplasty in Keratoconus
Authors: Rossi Costanza , Scorcia Vincenzo , Borselli Massimiliano , Giannaccare Giuseppe , Spena Rossella , Lucisano Andrea
Published: June 2023

This article aims to provide some personal surgical tips to increase the success rate of deep anterior lamellar keratoplasty (DALK), a very advantageous yet complex procedure for treating keratoconus. The most troublesome surgical step is obtaining a successful pneumatic dissection of the deep stromal tissue, allowing the exposure of a deep cleavage plane. The following tips may aid the trainee surgeon in mastering this step, among others: performing a deep trephination, using intraoperative anterior segment optical coherence tomography and/or femtosecond laser, exploiting the red reflex after pupil dilation, using the ophthalmic viscoelastic device in case of bubble formation failure. Approaches for reducing postoperative astigmatism are employing large-diameter grafts and using intraoperative keratoscopy with digital ring analysis. In conclusion, different tips can shorten the DALK learning curve and help to obtain better results from this surgery. Standardizing this surgical technique is paramount to reduce "human errors" and broaden its range of applicability.
ИНТЕЛЛЕКТУАЛЬНАЯ НАВИГАЦИЯ БЕСПИЛОТНОЙ АГРОТЕХНИКИ
Authors: Старовойтов Е. , Скиба Е.
Published: June 2023

Повышение эффективности сельскохозяйственного производства связано с внедрением робототехнических и беспилотных систем, к которым относится разработка беспилотной агротехники. Проведен анализ существующих технологий интеллектуальной навигации, позволяющих обеспечить полную автономность беспилотной агротехники.
ИЗМЕРЕНИЯ ДЕФЕКТОВ ФОРМЫ С ПОМОЩЬЮ КВАТЕРНИОННЫХ АЛГОРИТМОВ ГЕОМЕТРИЧЕСКОГО ПРЕОБРАЗОВАНИЯ
Authors: Епифанцев К.
Published: June 2023

Для анализа и выявления дефектов формы и снижения помех методических и систематических погрешностей оператора и внешней среды применяется алгоритм фильтрации значений измеренного сечения детали.
КАК ПРАВИЛЬНО ВЫБИРАТЬ И ОПТИМАЛЬНО ПРИМЕНЯТЬ ВЕКТОРНЫЕ АНАЛИЗАТОРЫ ЦЕПЕЙ. СЕМИНАР-­ПРАКТИКУМ «ОСНОВЫ ИЗМЕРЕНИЙ»
Authors: Ковалевский Ю.
Published: June 2023

21 марта 2023 года в Москве состоялся семинар-практикум
«Основы
измерений», организованный ООО «Планар» – российским производителем
контрольно-измерительного
оборудования. На мероприятии рассматривались
как основы проведения измерений в сфере СВЧ-электроники, так и более
специализированные темы, связанные с применением векторных
анализаторов цепей и подходами к автоматизации измерений.
ДОСТУПНЫЕ ИНДУКТИВНЫЕ КОМПОНЕНТЫ НА РОССИЙСКОМ РЫНКЕ
Authors: Крупнов И.
Published: June 2023

Компания «РУ Электроникс» постоянно расширяет ассортимент поставляемых электронных компонентов. В статье представлен обзор индуктивных компонентов, которые недавно пополнили склад «РУ Электроникс» и предназначены для замены решений таких компаний, как Bourns, TDK, Sumida, Murata, Wurth и др.
Automated Financial Documents Processing System Using Machine Learning
Authors: Deshmukh Gaurav Arvindrao
Published: June 2023

Abstract: In today’s world technology has affected each sector. But still, within the banking sector, we tend to face several problems. Bank handles giant volumes of cheques within the clearing method. The method involves several technical verifications as well as signature verification. A number of these steps are manual and need human intervention to finish the technique. This method needs high human capital preparation and longer interval. Fallacious practices are one in every one of the foremost problems plaguing banks in recent times. Hiring a lot of folks to manage the cheque verification method does not solve this issue.
Crop Prediction and Disease Detection in Cotton Using Machine Learning
Authors: Ghuge Mr. C.A. , Gangurde Tanmay , Narsale Uday , Pawar Mihir , Popale Ajinkya
Published: June 2023

Abstract: Cotton is one of the most important cash crops grown globally, and its yield is critical to the world's economy. Crop prediction and disease detection in cotton are essential for farmers to make informed crop management and production decisions. This project paperproposes a machine learning-based approach to predict cotton yield and detect disease in cotton plants. The proposed approach involves collectingdata from various sources, including weather data, soil data, and satellite images. The collected data will be preprocessed and analyzed to identify patterns and trends. Machine learningmodels such as regression, classification, and clustering will be developed to predict cotton yield and detect disease in cotton plants. The proposed approach will be implemented in a web-based application that will provide farmers with timely and accurate information about the yield and health of their cotton crops. The application will also provide recommendations on crop management practices based on data analysis and predictions. The proposed project aims to provide a cost-effective and efficient solution to cotton farmers for predicting crop yield and detecting disease in cotton plants. The proposed approach can also be extended toother crops, making it applicable to a wide range of agriculture-based industries.
Relevansi Nilai Informasi Akuntansi Di Indonesia Berdasar Simple Accounting-Based Fundamental Analysis
Authors: Murti Nugroho Wisnu , Indriyana Widyastuti
Published: June 2023

Decreasing the value relevance of accounting information issues cannot be separated from complexity of accounting standards and their implementation. This phenomenon is our motivation to examine whether the valuation model on the prospects of companies that prioritize the parsimony principle by using accounting information also indicates a decrease in the relevance of accounting information in Indonesia. We examined the f-score indicator which is referred to as a simple accounting-based fundamental analysis. This study observed all financial statements of issuers in Indonesia from 2006 to 2019 and their share prices in the secondary market during year t+1.We used multiple regression to estimate the value of r-square in each year of observation. This study could not find any indication of a decrease in the value relevance of accounting information during the observation period based on the r-square which is estimated by the f-score indicator. This finding can be a part of an empirical study that is not only related to value relevance, but also to the topic of accounting information readability.
Do Good Governance Business Sharia, Innovation and Financial Performance Affect Islamic Social Reporting Quality?
Authors: Oktavendi Tri Wahyu , Mawardi Fahmi Dwi
Published: June 2023

Islamic Social Reporting is an important aspect for companies with sharia principles in increasing their value. Reporting Disclosure currently only focuses on quantity not quality. Quantity can cause information anomaly because it is only based on the amount of disclosure, the way to minimize it is to focus on the quality of social Islamic disclosure. The purpose of this study was to analyze empirically the effect of financial performance (ROA), Innovation Disclosure (ID) and Good Governance Business Sharia (GGBS) on Islamic Social Disclosure (ISR). This study uses moderated regression analysis (MRA) with e-views 11. The sample used is a banking company registered with the financial services authority (OJK). The results of this study indicate that ROA has no effect on ISR, while the other variables, namely ID and GGBS, have an effect on ISR. The results of this research have practical implications, namely the practice of sharia governance and innovation is a part that needs to be strengthened to encourage management to improve the quality of ISR disclosure. In terms of theoretical implications, the results of this research become literature that can contribute to the development of the ISR research model.
The Impact of Agricultural Credit on Banana cultivation in Valle del Cauca, Colombia
Authors: Rivera-Acosta Javier , Xiuchuan Xu
Published: June 2023

This study aimed to explore the use and effect of agricultural credit disbursed from banks and financial institutions on banana yield in farmers from Valle del Cauca (Colombia) using data from the National Agricultural Census (2014). Additionally, it evaluated whether the effect of credit differs according to the items in which the farmer prefers to invest. For this purpose, because credits are not granted randomly, this research used the Propensity Score Matching (PSM) methodology to manage selection bias.  Initially, it was found through the probit model that having one's own agricultural machinery, using chemical fertilization to improve soil fertility, not belonging to an ethnic minority, and having some type of basic or higher education, increases the probability of obtaining an agricultural credit. On the other hand, the results suggest that credit has positive and significant effects on crop yield (6.2%), but the effect is greater if it is invested in land purchase and post-harvest processes, with an increase of 39% and 37% in yield, respectively.  On the other hand, this study also suggests that, if credit is invested in items not related to agricultural activity, yields can be affected with a 10% reduction. Finally, it is recommended that a public policy be implemented to encourage greater participation of banana farmers in Valle del Cauca in agricultural credit programs, given their low participation (10%) despite the high acceptability rate (86%).
At forstå og understøtte fællesskabers tilblivelse - meningsskabelse, materialitet og begær
Authors: Hall Lonni , Murphy Tine , Pallesen Eva
Published: June 2023

Artiklen bidrager til skandinavisk litteratur om fællesskabelse med et empirisk studie af fællesskabelse som proces. Studiet udfoldes ved hjælp af to procesteoretiske begrebstråde sensemaking-organisering-enactment og begær-begivenhed-materialitet inspireret af henholdsvis Weick og Deleuze. Analysen peger på, at fællesskabelse kan gribes som et fænomen drevet af intensivering af gensidigt enactment og materielle og narrative tråde til verden udenfor og tidligere fællesskaber. På baggrund af denne indsigt formulerer artiklen opmærksomheder, som er vigtige for, hvordan man kan understøtte fællesskabelse i praksis. Disse omfatter aktivitet, rum, stemninger, værtsskab og fælles fortællinger.
EFFECT OF DISCHARGE VARIATION ON THE PERFORMANCE OF SINGLE BLADE ARCHIMEDES SCREW TURBINE: PREDICTION WITH COMPUTATIONAL FLUID DYNAMIC
Authors: Cahyono Gunawan Rudi , Amrullah Apip , Ansyah Pathur Razi , Mikael N. Alexius , Reynaldi P.S.M. , Rusdi Rusdi
Published: June 2023

Constructing a small-scale hydroelectric power station that can run efficiently at a head lower than 10 m is one possible method for reducing the impact of the electricity crisis in remote areas of Indonesia. The Archimedes Screw turbine is one type of turbine that is ideal for discharges below 10 m. In this study, the simulation results show that the value of Turbulences Kinetic Energy is directly proportional to the increase in flow rate but inversely proportional to the level of immersion. This type of turbine is unless well in Indonesia due to a lack of information regarding the application of low head power plants. The turbine model that is suitable for the low head is investigated in this study. Before being tested, the turbine is first designed theoretically and then numerically evaluated. With discharges of 1 l/s, 2 l/s, and 3 l/s and turbine immersion levels of 30%, 50%, and 70%, ANSYS CFD (Computational Fluid Dynamic) software was used to investigate flow rate and level of immersion in the turbine. According to the investigation findings, the discharge has a considerable impact on the turbine's movement; the higher the flow rate, the higher the power to the turbine, which produces a torque on the turbine. The simulation findings indicate that the value of Turbulence Kinetic Energy is proportional to the increase in flow rate but inversely proportional to the level of immersion.
Efficacy of hyperbaric oxygen after microtia reconstruction using costal cartilage: A retrospective case-control study
Authors:   Department of Plastic and Reconstructive Surgery, Tonan Hospital, Sapporo, Hokkaido, Japan, Murao Naoki ,   Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, Oyama Akihiko ,   Department of Plastic and Reconstructive Surgery, School of Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan, Yamamoto Yuhei ,   Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, Funayama Emi ,   Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, Ishikawa Kosuke ,   Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, Maeda Taku ,   Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Published: June 2023

Introduction: Microtia reconstruction with autologous costal cartilage framework grafting is challenging because the three-dimensional structure of the ear is highly complex, and meeting the high aesthetic demands of patients can be difficult. If the skin flap overlying the framework is thinned to achieve a smooth and accentuated outline, a poor blood supply in the thin skin flap may lead to skin necrosis, exposure of the framework, and poor surgical results. Hyperbaric oxygen (HBO2) therapy can promote the healing of complex wounds and flaps. This study sought to determine the effectiveness of HBO2 therapy for prevention of postoperative complications after framework grafting in microtia reconstruction. Methods: We retrospectively evaluated postoperative complications and compared outcomes in pediatric patients who underwent costal cartilage grafting for microtia reconstruction at our institution between 2011 and 2015 according to whether or not they received postoperative HBO2 therapy. HBO2 therapy was applied once daily for a total of 10 sessions starting on the first postoperative day. Results: During the study period, eight patients received HBO2 therapy after costal cartilage grafting and 12 did not. There was no significant difference in the incidence of postoperative ulcers. However, the incidence of framework exposure was lower and the healing time was shorter in patients who received HBO2 therapy than in those who did not. Discussion: HBO2 therapy can be used safely in pediatric patients to reduce postoperative complications and improve the aesthetic outcome of microtia reconstruction. After costal cartilage grafting, HBO2 therapy should be considered as adjuvant therapy.
Autonomous navigation and adaptive path planning in dynamic greenhouse environments utilizing improved LeGO-LOAM and OpenPlanner algorithms
Authors: Zhang Baohua , Yao Xingbo , Bai Yuhao , Xu Dahua , Cao Guangzheng , Bian Yifan
Published: June 2023

The autonomous navigation of greenhouse robots depends on precise
mapping, accurate localization information and a robust path planning
strategy. However, the complex agricultural environment introduces
significant challenges to robot perception and path planning. In this
study, a hardware system designed exclusively for greenhouse
agricultural environments is presented, employing multi-sensor fusion to
diminish the interference of complex environmental conditions.
Furthermore, a robust autonomous navigation framework based on the
improved LeGO-LOAM and OpenPlanner has been proposed. In the perception
phase, a relocalization module is integrated into the LeGO-LOAM
framework. Comprising two key steps - map matching and filtering
optimization, it ensures a more precise pose relocalization. During the
path planning process, ground structure and plant density are considered
in our Enhanced OpenPlanner. Additionally, a hysteresis strategy is
introduced to enhance the stability of system state transitions.The
performance of the navigation system in this paper was evaluated in
several complex greenhouse environments. The integration of the
relocalization module significantly decreases the Absolute Pose Error
(APE) in the perception process, resulting in more accurate pose
estimation and relocalization information. Moreover, our Enhanced
OpenPlanner exhibits the capability to plan safer trajectories and
achieve more stable state transitions in the experiments. The results
underscore the effectiveness and robustness of our proposed approach,
highlighting its promising application prospects in autonomous
navigation for agricultural robots.
Mechanical &Thermal Analysis Of Natural Fiber Reinforced With Nano Clay particulates Subjected To Different Orientations
Authors: Pala Srinivasa Reddy , R Jagadeesh Kumar , S Roopa , P Kameswara Rao
Published: June 2023

In accordance with ASTM D638, the study investigates and analyses the
mechanical and thermal properties of banana bagasse fibre and epoxy
resin as a natural hybrid composite material, being biodegradable and
recyclable. The objective of the work is to develop composite materials
for packaging and transportation of light and medium weight mechanical
components. Using epoxy resin and hardener, hand laminates with
different compositions and fibre orientations were prepared. The
mechanical properties of the banana-bagasse hybrid composite were
improved by adding bagasse fibres with nanoparticles, which acted as
positive reinforcement and gave the composite higher strength and a
smooth surface. The flexibility of the composite was provided by the
banana fibres. The samples contained a banana fibre content of 60-65%
and a bagasse fibre concentration between 35-40% according to ASTM
D790. For the nonwoven with nano-clay powder, the maximum tensile test
value is 319.24 MPa, and the flexural strength was high at 664.2 Mpa for
the cross-ply laminate with nano-clay inclusion. Tensile strength is
increased by the use of nanoclay powder. ASTM standard specimens are
subjected to tensile, impact and thermogravimetric tests. Test results
can be validated by comparison with natural fibre composites with and
without inclusion of nanoclay. In the ASTM E1131 TGA test, natural fibre
reinforced composites with 1% inclusion of nanoclay performed better
than pure composites. In terms of residual weight, weight loss, derived
weight, and heat resistance, the cross-ply and angled-ply specimens
performed better than the unidirectional composites.
Computational approaches to identify sites of phosphorylation
Authors: Joyce Alex , Searle Brian
Published: June 2023

Due to their oftentimes ambiguous nature, phosphopeptide positional
isomers can present challenges in bottom-up mass spectrometry-based
workflows as search engine scores alone are often not enough to
confidently distinguish them. Additional scoring algorithms can remedy
this by providing confidence metrics in addition to these search
results, reducing ambiguity. Here we describe challenges to interpreting
phosphoproteomics data and review several different approaches to
determine sites of phosphorylation for both data-dependent and
data-independent acquisition-based workflows. Finally, we discuss open
questions regarding neutral losses, gas-phase rearrangement, and false
localization rate estimation experienced by both types of acquisition
workflows and best practices for managing ambiguity in phosphosite
determination.
Evaluation of expression systems for recombinant protein production in chicken egg bioreactors
Authors: Horiuchi Hiroyuki , Kajihara Ryota , Ezaki Ryo , Watanabe Tenkai , Ichikawa Kennosuke , Matsuzaki Mei
Published: June 2023

Chicken eggs have gained attention as excellent bioreactors because of
their genetic modifications. However, the development of chicken egg
bioreactors requires a long time from the construction of the production
system to the evaluation of the products. Therefore, in this study, we
established a chicken cell line producing ovalbumin (OVA) and
constructed a system for the rapid evaluation of the production system.
First, we knocked in the EF1α promoter upstream of the OVA
locus in chicken DF-1 cells for continuous OVA expression.
Furthermore, we analyzed and identified an ideal position at the
OVA locus for the insertion of useful protein genes to maximize
recombinant protein yield. We found that knocking in the EF1α
promoter upstream of exon1 yielded the maximum production of OVA
protein. In addition, we found that production efficiency was higher
with linking the recombinant gene hFGF2 to the 5′ side of the
OVA gene and with the use of 2A peptide for linkage. Therefore,
we established an OVA-expressing cell line and an evaluation system for
proteins in chicken egg bioreactors. Our findings may improve the
efficiency of chicken expression systems and expand their applications
in protein production.
조건적 강화를 사용한 문제 행동 감소와 과제 관련 행동 증가
Authors: Lund Emily M. , Hong Ee Rea
Published: June 2023

본 연구는 단일 대상 연구 설계인 중다 기초선 설계와 교대-처치 설계를 사용하여 언어적 촉진만 사용했을 때와 언어적 촉진과 시각적 촉진(그림)을 함께 사용하였을 때에 아동의 문제 행동과 과제 참여 행동에 미치는 효과를 비교하고자 설계 되었다. 연구 대상으로 만 3세의 자폐아동이 참여하였다. 이 아동은 과제가 주어졌을 때 언어적인 공격 행동과 신체적인 공격 행동을 보였다. 연구 결과 아동의 과제 참여 행동은 증가하였고, 아동의 문제행동은 감소되었다. 제언에서는 연구 결과를 바탕으로 이 연구의 제한점과 연구 방향 등에 대하여 논의되었다.
과학적 활동으로서의 특수교육, 응용행동분석, 그리고 단일대상연구
Authors: LeePark HyeSuk
Published: June 2023

오늘날, 특수교육이 과학적이어야 한다는 데는 아무도 이의를 제기하지 않을 것이다. 그렇다면 “과학적이란 말은 특수교육 현장에서 구체적으로 무엇을 의미하는가?” “과학적인 특수교육의 특징적 요소는 무엇인가?” 특수교육 분야를 이끌어 나가는 것이 관련 연구 활동이라고 했을 때, 특수교육의 연구활동의 개념적 기반이 위의 질문과 긴밀하게 관련되어 있다고 볼 수 있다. 특수교육이 현장에서 직면하는 학습 문제, 행동 문제의 해결의 과정이라는 점, 그리고 특수교육 관련 종사자들이 다양한 능력수준과 학습 성향을 보이는 집단을 대상으로 보편성이 결여된 교육적 환경에서 활동한다는 점을 고려한다면, 특수교육 종사자들이 직면하는 이러한 복잡한 상황을 반영하는 연구방법론의 필요성은 당연한 귀결이다. 단일대상연구는 분석적이며 그 분석의 단위는 개별적이다. 이러한 단일대상연구의 특징적 요소는 특수교육관련 연구자나 종사자들로 하여금 하나의 중재가 실행되는 현장에서 그 중재의 효율성을 평가하는 것을 가능하게 한다. 단일대상연구는 특정적 환경적 조건하에 보이는 행동변화를 개별적인 차원에서 조사하는 것이 특징이며, 이는 응용행동분석의 핵심적 특질과 긴밀히 관련이 되어있다. 또한, 이러한 점은 특수교육 관련 전문인들이 응용분석적 접근에서 과학에 기반한 교육을 제공하려 할 때 단일대상연구설계가 가지는 유용성을 말해준다. 본 논문에서는 과학에 기반한 교육의 특징적 요소와 응용행동분석의 특징을 특수교육과 관련해서 토론해보고자 한다. 이어 특수교육 분야에서 과학적 중재를 개발, 평가, 그리고 필요에 따라 수정을 할 때 단일대상연구설계가 보이는 유용성을 특수교육 분야가 직면하는 특수한 상황과 응용행동분석의 특징적 요소와 관련해서 토론하겠다. 마지막으로 미래의 특수교육 종사자 및 전문인을 배양하는 교육프로그램의 필수요소들 중 하나를 제시하고 응용행동분석 관련 석사과정 학생들이 특수교육 현장에서 실행한 연구 활동을 간략하게 보고하고자 한다.
Verbal Behavior Overview: Principles, Research Trends, and Implications
Authors: Nam Sang-Seok , Yang Moon-Bong , Jang Seyoung
Published: June 2023

Skinner (1957) proposed that language is learned behavior, and that the same basic principles of behavior that constitute the foundation of applied behavior analysis apply to verbal behavior. In this perspective, it can be true that humans acquire their ability to talk much in the same way that they learn nonverbal behaviors (reaching, grasping, crawling, etc.). This aspect can verify that the most significant socially significant aspects of human behavior involve verbal behavior. Language acquisition, social interaction, understanding, thinking, perception, and religion are all directly relevant to verbal behavior (Cooper, Heron, & Heward, 2007, p. 527). Therefore, one of the most significant characteristics of children with developmental disabilities is language and communication challenges. Verbal behavior holds promise for explaining and addressing many language problems of children with developmental disabilities including autism. This study has the purpose to suggest scientific and rational interventions for all verbal operants based on functional analysis and multiple control of elementary verbal behavior in several functions of echoic, tact, mand, interverbal, receptive, etc. This study analyzed publication trends and future expectations on verbal behavior and finally made several implications and suggestions at the end of this study in terms of assessment, intervention, and verbal behavior for AAC users. For AAC users, this study provided several strategies to support their learning verbal behavior operants. People with severe speech or language problems rely on AAC to supplement existing speech or replace speech that is not functional. Special augmentative aids, such as picture and symbol communication boards and electronic devices can help children express themselves.
The Effects of Individualized Positive Behavioral Supports on Problem Behaviors and On-Task Behavior of An Elementary School Student with Asperger’s Syndrome at Home
Authors: Lee Jonghee
Published: June 2023

The study investigated effects of individualized positive behavioral supports on problem behaviors and on-task behavior of an elementary school student with asperger‘s syndrome at home. An elementary school student with asperger‘s syndrome participated in this study. Based on the functional assessment, individualized positive behavioral supports plan was established for this child. A-B design has been used. And child’s problem behaviors were measured using a partial interval recording and on-task behavior was measured permanent product recording. The results are encouraging because they suggest that individualized positive behavioral supports at home could change on problem behaviors of a child with asperger‘s syndrome. Implication for implementing individualized positive behavioral supports were discussed.
Effects of the Activity-oriented Conflict Resolution Program based on Restorative Education on the Sense of Community of Elementary-School Students
Authors: Kim Un A
Published: June 2023

The purpose of this study was to evaluate the effects of activity-oriented conflict resolution program based on restorative education on the sense of community of elementary-school students. An object of study was the 24 students of a fourth grade class in an elementary school in Gyeonggi province. This intervention program was developed with the concept of restorative education for learning of useful conflict resolution way increasing of community engagement within the class. The program took effect to the students 8 times for four weeks with dependent variables. The recovery resilience and the sense of the responsibility and the bystander's attitude with dependent variables checked the program's effect to compare the score of pretest-posttest. The activity-oriented conflict resolution program for learning that the conflict cased a school violence resolve ways peacefully, through appeared significant difference statistician about the student's recovery resilience and the sense of the responsibility from the score at pretest-posttest. On the other hand, there was no significant difference between pretest-posttest with the bystander's attitude. The activity-oriented conflict applied this sturdy reflected high grade of element feature, could be effective for improving the self-sense of responsibility and cause analysis and emotional regulation through the various activities on students' hands. Ultimately, there are significance of this study that applied preventive approach about the school violence based on concept of restorative education.
The efficacy of Transitive Conditioned Motivating Operation training to mand in a child with developmental language disorder
Authors: Chung Mi Suk , Lee Jeong Hae , Lee Sung Bong
Published: June 2023

The purpose of this study was to determine the efficacy of Transitive Conditioned Motivating Operation(CMO-T) training to mand in a child with language delays over a year. A multiple-probe design across behaviors was used for the study. The authors designed the setting for examination which is applicable to CMO-T training. Once antecedent stimulus was presented, when the participant’s response was correct, he was provided by the object he manded. However, when he showed incorrect response, echoic prompts were provided, then he got the object he manded when he used echoic-mand. Three tasks for the intervention were chosen for CMO-T training; puzzles, pegs and threading beads. The authors examined alteration in the participant’s mand by applying CMO-T training to the tasks they have chosen for the intervention. Results indicated that the participant’s mand showed an increase in all three tasks during intervention phase, and he could use mand without any prompts during maintenance phase. It is significant that the result data of this study suggests detailed CMO-T training for establishing mand skills.
Experiences and Supportive Needs of Parents of Children with Developmental Disabilities on Behavior Rehabilitation Services
Authors: Kim Hye-Young , Lee Sung-Bong
Published: June 2023

The purpose of this study is to seek corrective strategies of issues based on analysis of experience and supportive needs of parents of children with developmental disabilities receiving behavior rehabilitation service. Participants of this study were 12 parents of children with developmental disabilities around Gyeonggi province who have been recipients of behavior rehabilitation service provided by qualified BCBAs(Board Certified behavior Analysts) for at least 3 months. In-depth interviews were conducted utilizing questionnaires in semi-structured format in order to analyze both experience and perceptions of behavior rehabilitation service. Based on acquired data, three main themes and ten subtitles were categorized using content analysis. From qualitative analysis, each one of three themes and its relevant subtitles were derived as follows; (1) the first theme of “experience on behavior rehabilitation service”, and its relevant subtitles of “the first meeting of the child and moment of diagnosis”, “treatment experience of my child and current situation”, “desired supportive treatment services”, “difficultly acquired behavior rehabilitation service”, “in search of behavior rehabilitation service centers”, and “experience of evidence-based behavior rehabilitation services”, (2) the next theme of “perceptions toward rehabilitation service”, and its relevant subtitles of “behavior change of children experiencing service”, and “expenses on behavior rehabilitation service”, and (3) the last theme of “supportive needs for behavior rehabilitation service”, and its subtitles of “reasons on others’ recommendation”, and “corrective needs to behavior rehabilitation service”. The result of this study can be utilized as a foundational resource to suggest future successful behavior services.
Effects of Antecedent-Based Intervention in Ecological Assessment Process on the Challenging Behaviors of Students with Intellectual Disabilities during Art Class
Authors: Kim Sun-Ok , Chae Soo-Jung
Published: June 2023

The purpose of this study was to investigate the effects of antecedent-based intervention in the ecological assessment process on the maladaptive behaviors of students with intellectual disabilities. The participants were second-grade middle school students with intellectual disabilities who are enrolled in a special school. The subjects' personal, environmental, and teacher-related factors were analyzed using ecological assessment- direct observation, reviews of existing records, interviews, questionnaires, and functional analysis. The antecedent-based intervention was developed based on the results of ecological assessment. There were three types of challenging behaviors: seat breakaway, noise generation, and task interruption. These behaviors were observed and recorded using the partial interval recording method(20-second intervals comprising 17-second observations with 3-second recordings). Multiple-baseline research design, a type of single-subject design, was employed across three participants for baseline, intervention, and maintenance phases. The data were analyzed using six visual analysis methods: level of data, trend, distribution of data, immediacy effect, percentage of non-overlapping data, and persistence of data. These methods were recently suggested by What Works Clearinghouse (Kratochwill et al., 2013) as quality indicators for single-subject research designs. The results showed that antecedent-based intervention in the ecological assessment process significantly decreased the challenging behaviors of students with intellectual disabilities during art class through a comparison of the intervention interval. The mean value of challenging behaviors was significantly less in all subjects, the percentage of non-overlapping data (PND) value was 100%, and Tau-U value was -1.00, indicating that the effects of the intervention were significant. Compared to the baseline value, the PND value between the baseline and maintenance was 100%, indicating that the intervention effects were significantly consistent. These analyses were discussed in terms of educational implications to apply in special education practices.
The Effects of Positive Behavior Support(PBS) on the Inattentive & Disruptive Behaviors of an At-risk Child
Authors: Woo Jeong-Hwa , Lee Byoung-In
Published: June 2023

The purpose of this study is to investigate the effect of positive behavioral support on the behaviour of children with at risk for disability. One at risk child with disability belonging to the public kindergarten was selected for the study & a functional assessment was conducted using the method of interview, direct observation, hypothesis setting, & verification to understand the function of the child's distracting behaviors and interference behavior. Based on the results, multiple elements including background & prior event mediation, replacement technical professor intervention, & subsequent outcome arbitration were conducted. In this study, multiple baseline across conditions design was used between situations, & measurements were taken using partial interval recording for 10 minutes each session. Basic lines & intervention were conducted in three situations, including story-sharing activity, free play activity, & lunch-time, focusing on kindergarten classrooms where activities of the children were conducted. In order to investigate the maintenance effect of the behavioral change after one week after the intervention, maintenance observation was performed in the same experimental environment as the baseline, and treatment fidelity and social validity were measured. The results of this study were derived as follows. First, the distracting behaviors of target child were effectively reduced through positive behavior support based on functional evaluation. Second, positive behavioral support based on functional assessment effectively reduced the interfering behavior of the target child. Third, even after ending positive behavioral support interventions, the effects of changes in the attention-based behaviour & interference behavior of the target child were maintained. As above, positive behavioral support has had a positive effect on the reduction of distracting behavior & disruptive behavior for at risk child. This result suggests that positive behavior support is effective in reducing the problem behaviors of young children with disabilities. The study was meaningful in that positive behavior support reduced the incidence of problem behavior in target child proved positive behavior support to be a useful strategy for managing behaviour for young children with disabilities in early childhood special education setting.
The Effects of Individualized Positive Behavior Support on Off-Task Behavior of a Kindergarten Child with Hearing Impairment in Special School
Authors: Lee Seo-Ok , Song Joo-Young , Kim Un-I , Kim Bo-Bae , Paik Eun-Hee
Published: June 2023

The purpose of this study was to examine the effects of the individualized positive behavior support on off-task behavior of a kindergarten child with hearing impairment. The participant was a kindergaten child with hearing impairment in a special school. The study utilized multiple baseline design across settings: art activities, theme activities, and after-school activities. Through the functional behavior assessment, the problem behavior was identified as off-task behavior: damaging work sheets, throwing things away, and putting things into the mouth. The findings from the study indicated that individualized positive behavior support was helpful reducing off-task behaviors of a kindergarten child with hearing impairment during both intervention and maintenance phase. The implication included the effects of individualized behavior support and the guidelines for future research.
The Effects of Individualized Positive Behavior Support on the Out-of-Seat Behavior of a Student with Autism Spectrum Disorder in Post-High School Specialized Vocational Program
Authors: Gweon Eunae , Yun Hyejung , Yoo Soowon , Lee Junghoon , Paik Eunhee
Published: June 2023

The purpose of this study was to examine the effects of the individualized positive behavior support (PBS) on out-of-seat behavior of a student in vocational education program after high school with autism spectrum disorder in transition program after special school graduation. A multiple baseline design across settings was utilized as a research design in this investigation. Functional behavioral assessment (FBA) was used to develop the problem behavior hypothesis and individualized positive behavior support has been provided as an intervention in special school setting. Results of the study indicated that individualized PBS decreased out-of-seat behavior for a student with autism spectrum disorder in transition program after schooling. The effects of PBS for a student with autism spectrum disorder in post-high school specialized vocational program suggested that more research of PBS intervention would be necessary to generalize the results of this study and quality of life perspective.
Causal Chain Analysis(CCA) of the Causes of Mothers’ Anxiety who Have Children with Developmental Disabilities with Serious Problem Behaviors
Authors: Baek Jongnam
Published: June 2023

The purpose of this study was to investigate the causes about mothers’ anxiety who have children with developmental disabilities with serious problem behaviors. For this study, the cause of mothers’ anxiety related to problem behaviors of children with developmental disabilities were analyzed using Causal Chain Analysis(CCA). Participants in this study were three mothers of children with developmental disabilities who attended a special school in C region. The semantic data was extracted from the data transfered through interview and interpreted by Causal Chain Analysis. The results of this study are as follows: First, the immediate causes of mothers’ anxiety were ‘the children’s learning opportunities loss due to problem behaviors’, ‘lack of skill in responding to problem behaviors’, ‘dependence on medical services’, and ‘physical and mental difficulties’; Second, the intermediate causes of mothers’ anxiety were ‘social isolation’ and ‘confusion over the cause of problem behavior’ and; Third, the root causes of mothers’ anxiety were ‘the absence of a school system to solve problem behaviors’. Finally, the results of this study were discussed and the implications, limitations, and follow-up studies were suggested.