bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical, Imaging and Procedural Risk Factors for Intrauterine Infective Complications After Uterine Fibroid Embolisation: A Retrospective Case Control Study
Authors: Mollier Josephine , Patel Neeral R. , Amoah Alison , Hamady Mohamad , Quinn Stephen D.
Published: August 2020

Introduction

This was a retrospective case–control study at a single tertiary centre investigating all UFE procedures between January 2013 and December 2018 for symptomatic fibroids. The aim was to determine the clinical, imaging and procedural risk factors which impact upon the risk of post-uterine fibroid embolisation (UFE) intrauterine infection. Cases were patients which developed intrauterine infection post-procedure, and controls were the background UFE population without infection.

Methods

Clinical demographics, presenting symptoms, uterine and fibroid characteristics on imaging and procedural variants were analysed. A p value of less than 0.05 was considered statistically significant. The main outcome measures were presence of infection and requirement of emergency hysterectomy.

Results

333 technically successful UFE procedures were performed in 330 patients. Infection occurred after 25 procedures (7.5%). 3 of these patients progressed to overwhelming sepsis and required emergency hysterectomy. Clinical obesity (BMI > 30) (OR 1.53 [1.18–1.99]) and uterine volume > 1000cm3 (2.94 [1.15–7.54]) were found to increase the risk of infection

Conclusions

UFE is generally safe in patients with symptomatic fibroids. Obese patients (BMI > 30) and those with large volume uteri (> 1000cm3) are at slight increased risk of developing infection and require appropriate pre-procedural counselling, as well as careful post-UFE follow-up. BMI and uterine volume may be useful to assess before the procedure to help to determine post-UFE infection risk.
Nurse-led care for the management of rheumatoid arthritis: a review of the global literature and proposed strategies for implementation in Africa and the Middle East
Authors: Uthman Imad , Almoallim Hani , Buckley Christopher D. , Masri Basel , Dahou-Makhloufi Chafia , El Dershaby Yasser , Sunna Nancy , Raza Karim , Kumar Kanta , Abu-Saad Huijer Huda , Tashkandi Nabeeha , Louw Ingrid , Adelowo Olufemi
Published: August 2020

Globally, increasing demand for rheumatology services has led to a greater reliance on non-physician healthcare professionals (HCPs), such as rheumatology nurse specialists, to deliver care as part of a multidisciplinary team. Across Africa and the Middle East (AfME), there remains a shortage of rheumatology HCPs, including rheumatology nurses, which presents a major challenge to the delivery of rheumatology services, and subsequently the treatment and management of conditions such as rheumatoid arthritis (RA). To further explore the importance of nurse-led care (NLC) for patients with RA and create a set of proposed strategies for the implementation of NLC in the AfME region, we used a modified Delphi technique. A review of the global literature was conducted using the PubMed search engine, with the most relevant publications selected. The findings were summarized and presented to the author group, which was composed of representatives from different countries and HCP disciplines. The authors also drew on their knowledge of the wider literature to provide context. Overall, results suggest that NLC is associated with improved patient perceptions of RA care, and equivalent or superior clinical and cost outcomes versus physician-led care in RA disease management. Expert commentary provided by the authors gives insights into the challenges of implementing nurse-led RA care. We further report practical proposed strategies for the development and implementation of NLC for patients with RA, specifically in the AfME region. These proposed strategies aim to act as a foundation for the introduction and development of NLC programs across the AfME region.
Orbitale Schussverletzungen
Authors: Mayer C. S. , Bohnacker S. , Storr J. , Klopfer M. , Cordeiro S. A. , Khoramnia R.
Published: August 2020

Hintergrund

Schussverletzungen kommen im Bereich der Ophthalmologie glücklicherweise selten vor. Die Behandlung eines betroffenen Patienten ist sowohl ophthalmologisch als auch emotional eine besondere Herausforderung.

Methodik

Wir berichten über 7 konsekutive Fälle von Patienten mit einer orbitalen Schussverletzung, die über einen Zeitraum von 11 Jahren in einem Universitätsklinikum vorstellig wurden. Ausgewertet wurden der Schadenshergang mit beteiligter Waffe, die Schussart, das Verletzungsmuster, die kraniale Bildgebung, die Therapie und der Verlauf.

Ergebnisse

Insgesamt konnten 7 Fälle von Schussverletzungen durch Waffen im Zeitraum von 2007 bis 2018 dokumentiert und ausgewertet werden. Alle 7 Patienten waren männlich. Das Alter betrug im Mittel 44 ± 27,5 Jahre. Fünfmal kam es durch einen Suizidversuch zu den Verletzungen, zweimal durch einen Unfall. Bis auf eine Schussverletzung mit einer Armbrust wurden Feuerwaffen verwendet. Viermal kam es dabei zu einem Steckschuss, zweimal zu einem Durchschuss und einmal zu einem Prellschuss. Der Endvisus lag bei den betroffenen Augen einmal bei einer einseitigen und ein weiteres Mal bei einer beidseitigen Amaurose, bei einem Patienten bei 1/35 MTV und bei 4 Patienten zwischen 0,2 und 0,7. Kein Patient ist an den unmittelbaren Folgen der Schussverletzung gestorben.

Diskussion

Schussverletzungen sind in Deutschland selten und haben meist einen suizidalen Hintergrund. Das Verletzungsmuster im Bereich der okulären Strukturen ist sehr variabel. Ein Rekonstruktionsversuch lohnt sich prinzipiell immer. Bei der Versorgung der Patienten ist eine interdisziplinäre Zusammenarbeit von Ophthalmologen und Neuro- und MKG- bzw. HNO-Chirurgen sowie Psychiatern notwendig.
Risk modeling in transcatheter aortic valve replacement remains unsolved: an external validation study in 2946 German patients
Authors: Wolff Georg , Shamekhi Jasmin , Al-Kassou Baravan , Tabata Noriaki , Parco Claudio , Klein Kathrin , Maier Oliver , Sedaghat Alexander , Polzin Amin , Sugiura Atsushi , Jung Christian , Grube Eberhard , Westenfeld Ralf , Icks Andrea , Zeus Tobias , Sinning Jan-Malte , Baldus Stephan , Nickenig Georg , Kelm Malte , Veulemans Verena
Published: August 2020

Background

Surgical risk prediction models are routinely used to guide decision-making for transcatheter aortic valve replacement (TAVR). New and updated TAVR-specific models have been developed to improve risk stratification; however, the best option remains unknown.

Objective

To perform a comparative validation study of six risk models for the prediction of 30-day mortality in TAVR

Methods and results

A total of 2946 patients undergoing transfemoral (TF,n = 2625) or transapical (TA,n = 321) TAVR from 2008 to 2018 from the German Rhine Transregio Aortic Diseases cohort were included. Six surgical and TAVR-specific risk scoring models (LogES I, ES II, STS PROM, FRANCE-2, OBSERVANT, GAVS-II) were evaluated for the prediction of 30-day mortality. Observed 30-day mortality was 3.7% (TF 3.2%; TA 7.5%), mean 30-day mortality risk prediction varied from 5.8 ± 5.0% (OBSERVANT) to 23.4 ± 15.9% (LogES I). Discrimination performance (ROC analysis,c-indices) ranged from 0.60 (OBSERVANT) to 0.67 (STS PROM), without significant differences between models, between TF or TA approach or over time. STS PROM discriminated numerically best in TF TAVR (c-index 0.66; range ofc-indices 0.60 to 0.66); performance was very similar in TA TAVR (LogES I, ES II, FRANCE-2 and GAVS-II all withc-index 0.67). Regarding calibration, all risk scoring models—especially LogES I—overestimated mortality risk, especially in high-risk patients.

Conclusions

Surgical as well as TAVR-specific risk scoring models showed mediocre performance in prediction of 30-day mortality risk for TAVR in the German Rhine Transregio Aortic Diseases cohort. Development of new or updated risk models is necessary to improve risk stratification.

Graphic abstract
The infinitesimal generator of the stochastic Burgers equation
Authors: Gubinelli Massimiliano , Perkowski Nicolas
Published: August 2020

We develop a martingale approach for a class of singular stochastic PDEs of Burgers type (including fractional and multi-component Burgers equations) by constructing a domain for their infinitesimal generators. It was known that the domain must have trivial intersection with the usual cylinder test functions, and to overcome this difficulty we import some ideas from paracontrolled distributions to an infinite dimensional setting in order to construct a domain ofcontrolled functions. Using the new domain, we are able to prove existence and uniqueness for the Kolmogorov backward equation and the martingale problem. We also extend the uniqueness result for “energy solutions” of the stochastic Burgers equation of Gubinelli and Perkowski (J Am Math Soc 31(2):427–471, 2018) to a wider class of equations. As applications of our approach we prove that the stochastic Burgers equation on the torus is exponentially$$L^2$$L2-ergodic, and that the stochastic Burgers equation on the real line is ergodic.
Neurotrophin signalling in amygdala-dependent cued fear learning
Authors: Meis Susanne , Endres Thomas , Lessmann Volkmar
Published: August 2020

The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced.
Existence results for closed Finsler geodesics via spherical complexities
Authors: Mescher Stephan
Published: August 2020

We apply topological methods and a Lusternik-Schnirelmann-type approach to prove existence results for closed geodesics of Finsler metrics on spheres and projective spaces. The main tool in the proofs are spherical complexities, which have been introduced in earlier work of the author. Using them, we show how pinching conditions and inequalities between a Finsler metric and a globally symmetric metric yield the existence of multiple closed geodesics as well as upper bounds on their lengths.
Influence of TEGDMA monomer on MMP-2, MMP-8, and MMP-9 production and collagenase activity in pulp cells
Authors: Lovász Bálint Viktor , Lempel Edina , Szalma József , Sétáló György , Vecsernyés Mónika , Berta Gergely
Published: August 2020

Objectives

Resin-based composites may leach monomers such as triethylene-glycol dimethacrylate (TEGDMA), which could contribute to intrapulpal inflammation. The aim of this investigation was to examine whether various concentrations of TEGDMA are able to influence dentally relevant Matrix metalloproteinase (MMP)-2, MMP-8, and MMP-9 production, total collagenase/gelatinase activity in pulp cells, and suggest possible signaling mechanisms.

Materials and methods

Pulp cells were cultured, followed by a 1-day exposure to sublethal TEGDMA concentrations (0.1, 0.2, and 0.75 mM). Total MMP activity was measured by an EnzCheck total collagenase/gelatinase assay, while the production of specific MMPs and the relative changes of phosphorylated, i.e., activated signaling protein levels of extracellular signal-regulated kinase (ERK)1/2, p38, c-Jun N-terminal kinase (JNK) were identified by western blot. Immunocytochemistry image data was also plotted and analyzed to see whether TEGDMA could possibly alter MMP production.

Results

An increase in activated MMP-2, MMP-8, and MMP-9 production as well as total collagenase activity was seen after a 24-h exposure to the abovementioned TEGDMA concentrations. Increase was most substantial at 0.1 (P = 0.002) and 0.2 mM (P = 0.0381). Concurrent p-ERK, p-p38, and p-JNK elevations were also detected.

Conclusions

Results suggest that monomers such as TEGDMA, leached from resin-based restorative materials, activate and induce the production of dentally relevant MMPs in pulp cells. Activation of ERK1/2, p38, or JNK and MMP increase may play a role in and/or can be part of a broader stress response.

Clinical relevance

Induction of MMP production and activity may further be components in the mechanisms of intrapulpal monomer toxicity.
Report of the intergovernmental panel on climate change: implications for the mental health policy of children and adolescents in Europe—a scoping review
Authors: Clemens Vera , von Hirschhausen Eckart , Fegert Jörg M.
Published: August 2020

Climate change is a worldwide challenge. Its consequences do encompass severe threats not only for the existence and somatic health, but also for the mental health of children and adolescents. Mental health can be impaired by three types of consequences. Direct consequences of climate change, such as natural disasters and indirect consequences, such as loss of land, flight and migration, exposure to violence, change of social, ecological, economic or cultural environment. Moreover, the increasing awareness of the existential dimension of climate change in children and adolescents can influence their well-being or challenge their mental health. Consequences of climate change for somatic health may interact with mental health or have psychological sequelae in children and adolescents. Based on the estimates by the United Nations Intergovernmental Panel on Climate Change, we have summarized current data on these differential pathways as to how climate change affects the mental health of children worldwide through selective literature research on Pubmed. Mental health sequelae of direct and indirect consequences of climate change, increased awareness and physical health problems caused by climate change are presented. We give insights into special vulnerabilities of children and adolescents and identify high-risk groups. As the “Fridays for Future” movement has been initiated in northern Europe, we will discuss these results with a focus on children and adolescents in Europe. The results indicate that climate change is a serious threat to children and adolescent mental health. Children´s rights, mental health and climate change should not continue to be seen as separate points; instead, they need to be brought together to address this major challenge determining the future of our children and their descendants.
Gender-related differences in migraine
Authors: Allais Gianni , Chiarle Giulia , Sinigaglia Silvia , Airola Gisella , Schiapparelli Paola , Benedetto Chiara
Published: August 2020

Migraine is considered mostly a woman’s complaint, even if it affects also men. Epidemiological data show a higher incidence of the disease in women, starting from puberty throughout life. The sex-related differences of migraine hold clinical relevance too. The frequency, duration, and disability of attacks tend to be higher in women. Because of this, probably, they also consult specialists more frequently and take more prescription drugs than men. Different mechanisms have been evaluated to explain these differences. Hormonal milieu and its modulation of neuronal and vascular reactivity is probably one of the most important aspects. Estrogens and progesterone regulate a host of biological functions through two mechanisms: nongenomic and genomic. They influence several neuromediators and neurotransmitters, and they may cause functional and structural differences in several brain regions, involved in migraine pathogenesis. In addition to their central action, sex hormones exert rapid modulation of vascular tone. The resulting specific sex phenotype should be considered during clinical management and experimental studies.
Breaking ties in collective decision-making
Authors: Bubboloni Daniela , Gori Michele
Published: August 2020

Many classic social preference (multiwinner social choice) correspondences are resolute only when two alternatives and an odd number of individuals are considered. Thus, they generally admit several resolute refinements, each of them naturally interpreted as a tie-breaking rule. A tie-breaking rule is compulsory every time a single final decision is needed. Unfortunately, using a tie-breaking rule on some social preference (multiwinner social choice) correspondence can dramatically compromise its properties. In particular, very often, the arithmetic relation between the number of alternatives and the number of voters does not allow to maintain both anonymity and neutrality. In those cases, the only possibility is to look at suitable different forms of symmetry that are coherent with the decision context. We find out conditions which make a social preference (multiwinner social choice) correspondence admit a resolute refinement fulfilling some weak versions of the anonymity and neutrality principles. We also clear when it is possible to obtain, for those resolute refinements, the reversal symmetry (immunity to the reversal bias). The theory we develop turns out to be useful in many common applicative contexts and allows to explicitly construct those refinements.
Impact of COVID-19 pandemic on waste management
Authors: Sarkodie Samuel Asumadu , Owusu Phebe Asantewaa
Published: August 2020

The containment of the spread of COVID-19 pandemic and limitations on commercial activities, mobility and manufacturing sector have significantly affected waste management. Waste management is critical to human development and health outcomes, especially during the COVID-19 pandemic. The invaluable service provided by the waste management sector ensures that the unusual heaps of waste that poses health risks and escalate the spread of COVID-19 is avoided. In this study, we assess the impact of COVID-19 pandemic on waste management by observing lockdown and social distancing measures. We found that the quantity of waste increased across countries observing the social distancing measure of staying at home. The intensification of single-use products and panic buying have increased production and consumption, hence thwarting efforts towards reducing plastic pollution. However, several countries have thus far instituted policies to ensure sustainable management of waste while protecting the safety of waste handlers.
Additive manufacturing of steels: a review of achievements and challenges
Authors: Haghdadi Nima , Laleh Majid , Moyle Maxwell , Primig Sophie
Published: August 2020

Metal additive manufacturing (AM), also known as 3D printing, is a disruptive manufacturing technology in which complex engineering parts are produced in a layer-by-layer manner, using a high-energy heating source and powder, wire or sheet as feeding material. The current paper aims to review the achievements in AM of steels in its ability to obtain superior properties that cannot be achieved through conventional manufacturing routes, thanks to the unique microstructural evolution in AM. The challenges that AM encounters are also reviewed, and suggestions for overcoming these challenges are provided if applicable. We focus on laser powder bed fusion and directed energy deposition as these two methods are currently the most common AM methods to process steels. The main foci are on austenitic stainless steels and maraging/precipitation-hardened (PH) steels, the two so far most widely used classes of steels in AM, before summarising the state-of-the-art of AM of other classes of steels. Our comprehensive review highlights that a wide range of steels can be processed by AM. The unique microstructural features including hierarchical (sub)grains and fine precipitates induced by AM result in enhancements of strength, wear resistance and corrosion resistance of AM steels when compared to their conventional counterparts. Achieving an acceptable ductility and fatigue performance remains a challenge in AM steels. AM also acts as an intrinsic heat treatment, triggering ‘in situ’ phase transformations including tempering and other precipitation phenomena in different grades of steels such as PH steels and tool steels. A thorough discussion of the performance of AM steels as a function of these unique microstructural features is presented in this review.
Sustainable packaging: an evaluation of crates for food through a life cycle approach
Authors: Del Borghi Adriana , Parodi Sara , Moreschi Luca , Gallo Michela
Published: August 2020

Purpose

The packaging system plays an essential role in the logistic chain and takes into account the rise in packaging demand and consumption. A study on sustainability was carried out through a comparative life cycle assessment in order to quantify and compare the environmental impacts of plastic, corrugated board and wood (solid, MDF and particleboard) crates used for food delivery. Single-use and multi-use systems were considered and compared.

Methods

According to ISO 14040 and ISO 14044, the whole life cycle of crates was divided into four primary phases: raw materials acquisition, crate manufacturing, transport (including the reuse, if applicable) and final disposal. The functional unit used for this study was 1 crate with an external dimension of 400 × 600 × 240 mm and with an inner volume of 50 l. The comparison focused on the critical parameters expected to have a higher influence on the results, such as the distances for delivery and the number of reuses for multi-use crates. All input data came from sector studies, literature and Ecoinvent database. The results were evaluated according to 8 impact categories. Two sensitivity analyses were performed.

Results and discussion

The most relevant impacts are linked to transport, electricity and raw materials contributions. Cumulative energy demand results show that the renewable energy resources in the case of plastic crates are about 3% while for the other type of crates exceed the 30% reaching the 77.5% in the case of solid wood crate. The environmental impacts result lower for multi-use plastic crate due to its possibility of being reused during its lifetime, avoiding the high impacts of the manufacturing. The best option among the single-use systems is the solid wood crate. The final results of the sensitivity analysis applied to the transport distances show that the impacts related to solid wood are more stable than plastic. Concerning the end-of-life scenarios, a significant decreasing (around 14.7%) in the global warming potential can be reached increasing the crates recycling till 100%.

Conclusions and recommendations

The best crate materials are plastic crates if a recovery system is planned; otherwise, the best choice is the wood crate. It is preferable to use raw material, such as solid wood than processed material, such as particle board, MDF and corrugated board. In performing this type of analysis, it is important to have accurate data, preferentially primary data, in particular for plastic crates as evidenced by the sensitivity analysis.
Activity analysis based modeling of global supply chains for sustainability assessment
Authors: Thies Christian , Kieckhäfer Karsten , Spengler Thomas S.
Published: August 2020

Assessing the sustainability of products is an intricate task that requires a thorough understanding of the underlying supply chains. Prominent challenges are the integration of the environmental, the economic, and the social dimension of sustainability as well as the consideration of spatial heterogeneity with regard to technology, environment, markets, and society. This paper proposes a novel modeling approach based on activity analysis to facilitate spatially differentiated sustainability assessments of global supply chains. The production and transportation activities in the supply chain and the exchanges between activities and their natural, economic, and social environments are formalized by means of activity vectors. Linking the activities and exchanges to specific locations allows for the calculation of regionalized sustainability indicators. The approach is used to analyze the environmental, economic, and social impacts of lithium-ion batteries. The comparison of alternative supply chain configurations with the spatially differentiated approach reveals that the assessment results differ significantly from those of the global average supply chain. These insights offer new opportunities to advance the design of sustainable supply chains.
Where to begin? Defining national strategies for implementing the 2030 Agenda: the case of Switzerland
Authors: Breu Thomas , Bergöö Michael , Ebneter Laura , Pham-Truffert Myriam , Bieri Sabin , Messerli Peter , Ott Cordula , Bader Christoph
Published: August 2020

Five years after adoption of the 2030 Agenda, there is a general lack of progress in reaching its Sustainable Development Goals—be it on national, regional, or global scales. Scientists attribute this above all to insufficient understanding and addressing of interactions between goals and targets. This study aims to contribute to the methodological conceptualization of the 2030 Agenda’s implementation at the national level. To this end, taking the case of Switzerland, we tested and enhanced existing approaches for assessing interactions among the 2030 Agenda’s targets and for analysing the systemic relevance of priority targets. Building on our insights, the article concludes with an eight-step proposal for creating knowledge to support national 2030 Agendas.
Hard Cladding by Supersolidus Liquid Phase Sintering: An Experimental and Simulation Study on Martensitic Stainless Steels
Authors: Farayibi P. K. , Blüm M. , Weber S.
Published: August 2020

Martensitic stainless steels are suitable for diverse structural applications but degrade when subjected to wear-prone activities in service. To enhance their service life, the densification of high Cr, martensitic, X190CrVMo20-4-1 tool steel powder on two different martensitic stainless steel substrates via supersolidus liquid-phase sinter (SLPS) cladding was investigated. The objective was to assess the influence of the difference in compositions of the martensitic stainless steels employed as substrates on the interfacial diffusion, microstructure, hardness and bonding strength of the steel-to-steel claddings. Computational thermodynamics and diffusion simulations were employed to supplement experimental findings. Owing to interdiffusion, a M7C3 carbide-free, banded region exists in the X190 adjacent to the interface with the width dictated by chemical potential gradient of carbon. The hardness of the substrate was lower near the interface region because of carbon enrichment, which promoted the presence of retained austenite. An interfacial strength of 798 MPa was achieved with fairly ductile X190 matrix near the cladding interface as the fracture surface was characterized by mixed fracture modes of dimple rupture and cleavage with localized quasi-cleavage features. Experimental observations and computational simulations are in agreement. The implications of the SLPS cladding technique are discussed in the context of tool development.
Cognitive and Neurologic Rehabilitation Strategies for Central Nervous System HIV Infection
Authors: Chan Terrence , Marta Monica , Hawkins Camilla , Rackstraw Simon
Published: August 2020

Purpose of Review

Cognitive impairment leading to disability is increasingly seen in people living with human immunodeficiency virus (PLWH). Rehabilitation can alleviate the effects of cognitive impairment upon function. The aim of this paper is to discuss the strategies that have been used in cognitive and neurologic rehabilitation in PLWH.

Recent Findings

Studies examining pharmacological and non-pharmacological strategies were analysed. Medical management of HIV and co-morbidities should be optimised. Non-pharmacological strategies, including nerve stimulation techniques, exercise-based interventions, and paper and computer-based cognitive rehabilitation, have some evidence supporting their use in PLWH either as stand-alone interventions or as part of a multidisciplinary approach.

Both pharmacological and non-pharmacological rehabilitation strategies have been used with PLWH. More intervention trials are needed to assess cognitive and neurological rehabilitation strategies and further evaluate their potential benefit in PLWH.
Harvesting a remote renewable resource
Authors: Upmann Thorsten , Behringer Stefan
Published: August 2020

In standard models of spatial harvesting, a resource is distributed over a continuous domain with an agent who may harvest everywhere all the time. For some cases though (e.g., fruits, mushrooms, algae), it is more realistic to assume that the resource is located at a fixed point within that domain so that an agent has to travel in order to be able to harvest. This creates a combined travelling–and–harvesting problem where slower travel implies a lower travelling cost and, due to a later arrival, a higher abundance of the resource at the beginning of the harvesting period; this, though, has to be traded off against less time left for harvesting, given a fixed planning horizon. Possible bounds on the controls render the problem even more intricate. We scrutinise this bioeconomic setting using a two-stage optimal control approach, and find that the agent economises on the travelling cost and thus avoids to arrive at the location of the resource too early. More specifically, the agent adjusts the travelling time so as to be able to harvest with maximum intensity at the beginning and the end of the harvesting period, but may also find it optimal to harvest at a sustainable level, where the harvesting and the growth rate of the stock coincide, in an intermediate time interval.
The Parker problem: existence of smooth force-free fields and coronal heating
Authors: Pontin David I. , Hornig Gunnar
Published: August 2020

Parker (Astrophys J 174:499, 1972) put forward a hypothesis regarding the fundamental nature of equilibrium magnetic fields in astrophysical plasmas. He proposed that if an equilibrium magnetic field is subjected to an arbitrary, small perturbation, then—under ideal plasma dynamics—the resulting magnetic field will in general not relax towards a smooth equilibrium, but rather, towards a state containing tangential magnetic field discontinuities. Even at astrophysical plasma parameters, as the singular state is approached dissipation must eventually become important, leading to the onset of rapid magnetic reconnection and energy dissipation. Thistopological dissipationmechanism remains a matter of debate, and is a key ingredient in thenanoflaremodel for coronal heating. We review the various theoretical and computational approaches that have sought to prove or disprove Parker’s hypothesis. We describe the hypothesis in the context of coronal heating, and discuss different approaches that have been taken to investigating whether braiding of magnetic field lines is responsible for maintaining the observed coronal temperatures. We discuss the many advances that have been made, and highlight outstanding open questions.
Olfactory outcomes in the management of aspirin exacerbated respiratory disease related chronic rhinosinusitis
Authors: Spielman Daniel B. , Overdevest Jonathan , Gudis David A.
Published: August 2020

Patients with aspirin exacerbated respiratory disease (AERD) experience a severe and recalcitrant form of chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma, which are exacerbated by aspirin/NSAID ingestion. As compared with aspirin‐tolerant CRSwNP, patients with AERD experience more severe olfactory dysfunction, which is one of the key contributors to the observed decrease in quality of life (QOL) in this disease. The objective of this paper is to review the published olfactory outcomes observed with various treatment modalities.
Justice for George Floyd and a reckoning for global mental health
Authors: Weine Stevan , Kohrt Brandon A. , Collins Pamela Y. , Cooper Janice , Lewis-Fernandez Roberto , Okpaku Samuel , Wainberg Milton L.
Published: August 2020

In the wake of George Floyd's killing by police in Minneapolis and the global response inspired by Black Lives Matter, it is time for the field of global mental health to reexamine how we have acknowledged and addressed racism in our institutions, our research, and our mental health services. In solidarity with street level responses, this is an important opportunity to understand and collaboratively respond to public demand for systemic change. To respond effectively, it is vital to (1) be aware of the colonial history that influences today's practices, and move forward with anti-colonial and anti-racist actions; (2) identify where and why diversity and representation are lacking in the global mental health workforce, then follow steps to combat these disparities; and (3) work with communities and institutions to end both police violence and structural violence.
The age of surface-exposed ice along the northern margin of the Greenland Ice Sheet
Authors: MacGregor Joseph A. , Fahnestock Mark A. , Colgan William T. , Larsen Nicolaj K. , Kjeldsen Kristian K. , Welker Jeffrey M.
Published: August 2020

Each summer, surface melting of the margin of the Greenland Ice Sheet exposes a distinctive visible stratigraphy that is related to past variability in subaerial dust deposition across the accumulation zone and subsequent ice flow toward the margin. Here we map this surface stratigraphy along the northern margin of the ice sheet using mosaicked Sentinel-2 multispectral satellite imagery from the end of the 2019 melt season and finer-resolution WorldView-2/3 imagery for smaller regions of interest. We trace three distinct transitions in apparent dust concentration and the top of a darker basal layer. The three dust transitions have been identified previously as representing late-Pleistocene climatic transitions, allowing us to develop a coarse margin chronostratigraphy for northern Greenland. Substantial folding of late-Pleistocene stratigraphy is observed but uncommon. The oldest conformal surface-exposed ice in northern Greenland is likely located adjacent to Warming Land and may be up to ~55 thousand years old. Basal ice is commonly exposed hundreds of metres from the ice margin and may indicate a widespread frozen basal thermal state. We conclude that the ice margin across northern Greenland offers multiple opportunities to recover paleoclimatically distinct ice relative to previously studied regions in southwestern Greenland.
Willpower with and without effort
Authors: Ainslie George
Published: August 2020

Most authors who discuss willpower assume that everyone knows what it is, but our assumptions differ to such an extent that we talk past each other. We agree that willpower is the psychological function that resists temptations – variously known as impulses, addictions, or bad habits; that it operates simultaneously with temptations, without prior commitment; and that use of it is limited by its cost, commonly called effort, as well as by the person's skill at executive functioning. However, accounts are usually not clear about how motivation functions during the application of willpower, or how motivation is related to effort. Some accounts depict willpower as the perceiving or formation of motivational contingencies that outweigh the temptation, and some depict it as a continuous use of mechanisms that interfere with re-weighing the temptation. Some others now suggest that impulse control can bypass motivation altogether, although they refer to this route as habit rather than willpower.

It is argued here that willpower should be recognized as either or both of two distinct functions, which can be calledresolveandsuppression. Resolve is based on interpretation of a current choice as a test case for a broader set of future choices, which puts at stake more than the outcome of the current choice. Suppression is inhibiting valuation of (modulating) and/or keeping attention from (filtering) immediate alternatives to a current intention. Perception of current choices as test cases for broader outcomes may result in reliable preference for these outcomes, which is experienced as an effortlesshabit– a successful result of resolve, not an alternative method of self-control. Some possible brain imaging correlates are reviewed.
Framing conservation: ‘biodiversity’ and the values embedded in scientific language
Authors: Elliott Kevin C
Published: August 2020

The global loss of biodiversity is one of the most important challenges facing humanity, and a multi-faceted strategy is needed to address the size and complexity of this problem. This paper draws on scholarship from the philosophy of science and environmental ethics to help address one aspect of this challenge: namely, the question of how to frame biodiversity loss in a compelling manner. The paper shows that the concept of biodiversity, like many scientific concepts, is value-laden in the sense that it tends to support some ethical or social values over others. Specifically, in comparison with other potential concepts, the biodiversity concept is tied more closely to the notion that nature has intrinsic value than to the idea that nature is valuable instrumentally or relationally. Thus, alternative concepts could prove helpful for communicating about biodiversity loss with those who emphasize different value systems. The paper briefly discusses five concepts that illustrate the potential for using different concepts in different contexts. Going forward, conservationists would do well to recognize the values embedded in their language choices and work with social scientists to develop a suite of concepts that can motivate the broadest swath of people to promote conservation.
Appropriate technology's prompt to ‘architectural thinking’, c. 1976
Authors: Sadler Simon
Published: August 2020

This article argues that the UK’s vanguard magazine Architectural Design (AD) promoted appropriate technology (AT) to prompt ‘architectural thinking’ about the late-modern crisis following the collapse of post-War consensus in the welfare state and its architecture. This was to be a crisis settled by the decade’s end in postmodernism and neoliberalism, a new consensus so overwhelming that it was heralded even in AT, especially those variants drawn from the Californian libertarianism of the Whole Earth Catalog. But British AT was also drawing from the UK’s eco-socialist Radical Technology group and its publication, whose chief artist, anarchist Clifford Harper, and editor Peter Harper, contributed to AD. At the beginning of the decade, the magazine’s sub-editor Martin Pawley insisted on the role of a lateral ‘architectural thinking’ of the sort inherent to AT, which pointed to futures by turn libertarian, socialist, and social democratic (its first advocate, Ernst Schumacher, had been a stalwart Keynesian and manager of nationalisation). Beyond politics per se, paradox and analogy were keynote to the decade’s epistemological uncertainty, from the ‘wickedness’ besetting design as a ‘problem-solving’ activity, to a post-structuralism eroding the long Enlightenment project, to a post-colonialism challenging Eurocentric technologies of exploitation. Indeed, AD could position design and AT as ‘non-aligned third way’ much as the so-called Third World indicated a ‘third way’ between the capitalism and communism of the so-called First and Second Worlds.
Spaces of rehearsal: theorising socio-spatial practices in a postconflict context
Authors: Morrow Ruth , Mutschler Peter , Waddell Timothy
Published: August 2020

This paper sets out the socio-spatial practices of PS2 and Street Society in territorialised, post conflict Northern Ireland – whose work combines pedagogical and improvisation theory to prototype distinctive social models. These practices were formed by a continual process of practical involvement and reflection (through writing) and evaluation (funding permitting), alongside the author-practitioners' search for theoretical concepts that would bring clarity and an alternative perspective to the processes and outcomes. Concepts and approaches taken from pedagogical theory and, uniquely in the case of architecture, improvisational theory, will be used to explore critical aspects of the specific practices, and more generally assert that such socio-spatial ‘street pedagogy’ offers a space of rehearsal and ultimately, a site for the development of socially-just aesthetics. The paper thus proposes a theoretical scaffolding for practices which increase diversity and diminish resource consumption in the contexts of climate emergency and a politics of precarity.
The effects of aging on bilingual language: What changes, what doesn't, and why
Authors: Reifegerste Jana
Published: August 2020

Substantial research has examined cognition in aging bilinguals. However, less work has investigated the effects of aging on language itself in bilingualism. In this article I comprehensively review prior research on this topic, and interpret the evidence in light of current theories of aging and theories of bilingualism. First, aging indeed appears to affect bilinguals’ language performance, though there is considerable variability in the trajectory across adulthood (declines, age-invariance, and improvements) and in the extent to which these trajectories resemble those found in monolinguals. I argue that these age effects are likely explained by the key opposing forces of increasing experience and cognitive declines in aging. Second, consistent with some theoretical work on bilingual language processing, the grammatical processing mechanisms do not seem to change between younger and older bilingual adults, even after decades of immersion. I conclude by discussing how future research can further advance the field.
Associations of the consumer food environment with eating behaviours and BMI
Authors: Zhao Anne W , McGowan Cyanna C , Zenk Shannon N , Kershaw Kiarri N
Published: August 2020

Objective:

To examine cross-sectional associations of four aspects of the consumer food environment – price, availability, marketing and product placement – with BMI and fruit and vegetable intake.

Design:

This cross-sectional study measured the consumer food environment using grocery store audits and surveys. Outcomes were measured through surveys and physical exams. Multivariable linear regression models were run; models were all adjusted for age, neighbourhood, education, race/ethnicity and financial burden.

Setting:

Non-proportional quota sample of four socio-economically and racial/ethnically diverse neighbourhoods in Chicago, IL.

Participants:

Women (n 228) aged 18–44 years.

Results:

Participants who reported seeing healthy food marketing had a higher vegetable intake (β = 0·24, 95 % CI 0·06, 0·42). There was some suggestive evidence that participants who shopped at stores that were more expensive (β = −0·90, 95 % CI −1·94, 0·14) had lower BMI, but this association was not statistically significant. Multivariable regression models did not indicate any significant association between any measure of the consumer food environment and fruit intake.

Conclusions:

Our findings add to the growing interest in the role of the consumer food environment in health behaviours. Further research is needed to better understand the role of price and marketing characteristics on eating behaviours and BMI.
DERIVED NON-ARCHIMEDEAN ANALYTIC HILBERT SPACE
Authors: António Jorge , Porta Mauro
Published: August 2020

In this short paper, we combine the representability theorem introduced in [Porta and Yu, Representability theorem in derived analytic geometry, preprint, 2017, arXiv:1704.01683; Porta and Yu, Derived Hom spaces in rigid analytic geometry, preprint, 2018, arXiv:1801.07730] with the theory of derived formal models introduced in [António, $p$-adic derived formal geometry and derived Raynaud localization theorem, preprint, 2018, arXiv:1805.03302] to prove the existence representability of the derived Hilbert space $\mathbf{R}\text{Hilb}(X)$ for a separated $k$-analytic space $X$. Such representability results rely on a localization theorem stating that if $\mathfrak{X}$ is a quasi-compact and quasi-separated formal scheme, then the $\infty$-category $\text{Coh}^{-}(\mathfrak{X}^{\text{rig}})$ of almost perfect complexes over the generic fiber can be realized as a Verdier quotient of the $\infty$-category $\text{Coh}^{-}(\mathfrak{X})$. Along the way, we prove several results concerning the $\infty$-categories of formal models for almost perfect modules on derived $k$-analytic spaces.
AI in actuarial science – a review of recent advances – part 1
Authors: Richman Ronald
Published: August 2020

Rapid advances in artificial intelligence (AI) and machine learning are creating products and services with the potential not only to change the environment in which actuaries operate but also to provide new opportunities within actuarial science. These advances are based on a modern approach to designing, fitting and applying neural networks, generally referred to as “Deep Learning.” This paper investigates how actuarial science may adapt and evolve in the coming years to incorporate these new techniques and methodologies. Part 1 of this paper provides background on machine learning and deep learning, as well as an heuristic for where actuaries might benefit from applying these techniques. Part 2 of the paper then surveys emerging applications of AI in actuarial science, with examples from mortality modelling, claims reserving, non-life pricing and telematics. For some of the examples, code has been provided on GitHub so that the interested reader can experiment with these techniques for themselves. Part 2 concludes with an outlook on the potential for actuaries to integrate deep learning into their activities. Finally, a supplementary appendix discusses further resources providing more in-depth background on machine learning and deep learning.
Germination ecology of dwarf amaranth (Amaranthus macrocarpus): an emerging weed in Australian cotton cropping systems
Authors: Asaduzzaman Md , Koetz Eric , Wu Hanwen
Published: August 2020

Dwarf amaranth (Amaranthus macrocarpus Benth.) is a problematic broadleaf weed in many crops in Australia; however, no information is available on the germination ecology of this species. Seeds from two populations of this species were collected from Hillston, NSW, Australia (D-P-01), and Yandilla, QLD, Australia (D-P-02). Seeds were germinated at a range of constant (20 to 45 C) and alternating temperatures (30/20, 35/25, 40/30, and 45/35 C day/night). For the constant temperature treatments, the highest germination occurred at 35 C for D-P-01 (89%) and D-P-02 (82%). Germination was higher at the alternating day/night temperature of 40/30 C for both populations D-P-01 (91%) and D-P-02 (85%). Seed germination of both populations was stimulated by light, which indicates a great amount of emergence of A. macrocarpus can occur on bare ground such as crop seed beds. Results also revealed that this species tolerates a moderate level of salinity and can germinate in slightly alkaline soil conditions. The emergence of this species was highest (47%) for the seed buried at 0.5-cm depth in grey cracking alkaline soil compared with seed buried at the same depth in acidic red soils. These results suggest that soil inversion by tillage to bury weed seeds below their maximum emergence depth could serve as an important tool for managing A. macrocarpus. The results from this study will help in developing more sustainable and effective integrated weed management tactics for the control of this weed and weeds with similar responses in summer cropping systems.