bluuebunny/crossref_metadata_2025 huggingface dataset:
Correcting Misperceptions About Genetically Modified Food on Social Media: Examining the Impact of Experts, Social Media Heuristics, and the Gateway Belief Model
Authors: Bode Leticia , Vraga Emily K. , Tully Melissa
Published: December 2020

We experimentally test whether expert organizations on social media can correct misperceptions of the scientific consensus on the safety of genetically modified (GM) food for human consumption, as well as what role social media cues, in the form of “likes,” play in that process. We find expert organizations highlighting scientific consensus on GM food safety reduces consensus misperceptions among the public, leading to lower GM misperceptions and boosting related consumption behaviors in line with the gateway belief model. Expert organizations’ credibility may increase as a result of correction, but popularity cues do not seem to affect misperceptions or credibility.
From Customer-, to Actor-, to Stakeholder Engagement: Taking Stock, Conceptualization, and Future Directions
Authors: Hollebeek Linda D. , Kumar V. , Srivastava Rajendra K.
Published: December 2020

Despite the significant strides made in the customer engagement literature, the need to understand any marketing actor’s engagement (vs. merely the customer’s) is increasingly recognized. Therefore, the budding actor engagement (AE) concept, which is commonly grounded in S-D logic, describes any marketing actor’s engagement, including that of customers, firms, employees, suppliers, and so on. However, while S-D logic-informed AE offers important insight into actors’ mutual value creation, it largely overlooks the sociopolitical notions that (a) actors’ potentially diverging goals may see them act against (vs. pro) focal others’ interests and (b) different actors may extract differing levels of value from interactions, as advanced in stakeholder theory. Based on these gaps, we extend existing AE research by developing integrative stakeholder theory/S-D logic-informed stakeholder engagement (SE). We deduce five core SE tenets, from which we conceptualize SE as a stakeholder’s state-based, boundedly volitional resource endowment in his/her role-related interactions, activities, and/or relationships. We conclude this article by discussing important implications that arise from our analyses and by identifying avenues for further research.
Development and Validation of a Prediction Model for 6-Month Societal Costs in Older Community Care-Recipients in Multiple Countries; the IBenC Study
Authors: van Lier Lisanne I , Bosmans Judith E , van der Roest Henriëtte G , Heymans Martijn W , Garms-Homolová Vjenka , Declercq Anja , V Jónsson Pálmi , van Hout Hein PJ
Published: December 2020

This study aims to develop and validate a prediction model of societal costs during a period of 6-months in older community care-recipients across multiple European countries. Participants were older community care-recipients from 5 European countries. The outcome measure was mean 6-months total societal costs of resource utilisation (healthcare and informal care). Potential predictors included sociodemographic characteristics, functional limitations, clinical conditions, and diseases/disorders. The model was developed by performing Linear Mixed Models with a random intercept for the effect of country and validated by an internal-external validation procedure. Living alone, caregiver distress, (I)ADL impairment, required level of care support, health instability, presence of pain, behavioural problems, urinary incontinence and multimorbidity significantly predicted societal costs during 6 months. The model explained 32% of the variation within societal costs and showed good calibration in Iceland, Finland and Germany. Minor model adaptations improved model performance in The Netherland and Italy. The results can provide a valuable orientation for policymakers to better understand cost development among older community care-recipients. Despite substantial differences of countries’ care systems, a validated cross-national set of key predictors could be identified.
Prevalence of Musculoskeletal Pain Among Academic Staff of Mekelle University, Ethiopia
Authors: Meaza Habtamu , Temesgen Melaku Hailu , Redae Getachew , Hailemariam Teklehaimanot Tekle , Alamer Abayneh
Published: December 2020

Background:

Musculoskeletal pain is a leading cause of morbidity, low productivity. Thus; not only affecting the individual’s quality of life; it also creates a burden in the health system and affects the productivity of their institution and the country at large. The prevalence of musculoskeletal pain among academic staff in developed countries ranges from 47% to 85%. However, there was a scarce of studies in developing country, particularly in the study area.

Purpose:

the aim of the research was to assess the burden of musculoskeletal pain and associated factors among Mekelle University academic staff.

Patients and Methods:

An institutional based cross-sectional study was enrolled on 449 participants with a response rate of 92.2%. Multistage sampling technique was deployed to select representatives. Participants under the selected schools, institutes and departments were selected using random sampling method. Data was collected through face to face interview using structured and standardized Nordic questionnaire by trained data collectors at Mekelle University. Binary logistic regression was used to assess the association between dependent and independent variables. In bivariate logistic regression variables which have P value of <.25 were modeled to multivariate logistic regression. Those variables with P-value of <.05 with 95% CI in multivariate model were taken as statistically significant.

Results:

This study found that burden of musculoskeletal pain among Mekelle University academic staff in the previous 12 month was 65.2%, and in the last 7 days was 29%. Neck pain (41.5%) was most prevalent followed by low back pain (40.3%). Female gender (OR = 3.02, 95% CI: 1.58-5.76), Body mass index ⩾25 (OR = 3.68, 95% CI: 1.15-11.39), working hours per day (OR = 3.1, 95% CI: 1.54-6.38), and physical inactivity (OR = 3.48, 95% CI: 1.69-7.16), were the independent factors positevly associated with musculoskeletal pain.

Conclusion:

The burden of musculoskeletal pain among Mekelle University academic staff was common. Female gender, being overweight and obese, working >5 hours per day, and being physically inactive increase the odds of experiencing musculoskeletal pains among academicians. Therefore the university authorities and all academicians are recommended that to take preventable measures of musculoskeletal pain.
Constraints on innovation in English language teaching in hinterland regions of China
Authors: Murray Neil , Liddicoat Antony J. , Zhen Gavin , Mosavian Penny
Published: December 2020

Since the start of the twenty-first century, English has come to be seen by the Chinese government as a linchpin of its continued economic and political influence. Its resultant efforts to promote innovation in English language teaching align with the aspirations of a population, many of whom regard competency in English as a determiner of opportunity and success in their careers, and thus a vehicle through which to provide a good quality of life for themselves and their families. However, despite government-driven initiatives to improve English language education, change has been slow to materialize, especially outside of the main urban areas of Eastern China. Here, we report on a study that sought to explore the constraints governing attempts by teachers of English to innovate in universities located in some of the so-called ‘hinterland’ regions of Southwestern China. Key determinants that emerged, and which we discuss, included time pressure and competing priorities; scepticism towards new ideas; lack of investment in resources; the primacy of the textbook; students’ language proficiency; and opportunities for professional development. Together, these findings indicate the need for a change of culture if innovation is to be welcomed, both in principle and in practice, as a driver of positive change in the teaching of English in these universities. Teachers, their line managers, and university senior managers need to feel willing and able to engage freely in constructive and informed discourse, and in doing so consider recalibrating institutional priorities, thereby helping reconcile the pressures and tensions currently experienced by English language teachers and which impede progress.
Self-tracking of/and time: From technological to biographical and political temporalities of work and sitting
Authors: Saukko Paula , Weedon Amie
Published: December 2020

Self-tracking devices have been observed to accelerate time, be used sporadically and busyness being a barrier to use at work. Drawing on notion of multiple temporalities, this article expands the focus on temporalities of users’ engagement with technologies to analysing them within broader biographical, institutional and political times. The argument is grounded in interviews with UK public sector office workers self-tracking sitting time that featured the following three themes: (1) the participants related their sitting to deteriorated work conditions after government austerity politics and redundancies, (2) the pressurised rhythm of work made it difficult to reduce sitting time and fostered a sense of discontent and powerlessness and (3) the workers did not self-track in their free time, defined as free from monitoring. We suggest that the analytical lens of multiple temporalities expands understanding of user experiences as well as illuminates lived contemporary political and institutional times, characterised by both discontent and powerlessness.
The making of a global medical tourism destination: From state-supported privatisation to state entrepreneurialism in healthcare in Turkey
Authors: Yılmaz Volkan , Aktas Puren
Published: December 2020

Examining medical tourism, especially in countries with publicly funded and organised healthcare systems, offers a gateway into an understanding of the changing role of the state in contemporary societies. Drawing on a comprehensive documentary review, this article examines the evolving role of the state in transforming Turkey into a global medical tourism destination. The article identifies two stages of state involvement in medical tourism: the period after the 2003 healthcare reform and the rise of an entrepreneurial healthcare state since 2013. The article suggests that the state, in the first period, performed a facilitator role by supporting privatisation in healthcare provision; in the second period, it assumed an entrepreneurial role, establishing large hospital complexes through a public-private partnership and created a public corporation to capitalise on the export of healthcare services. The Turkish case demonstrates that the role of the state in medical tourism is subject to change over time, depending on shifts in governmental strategies for healthcare and government-business relations. The article also offers evidence on the continued relevance of the multidimensional engagement of the state in healthcare that cuts across economic and social policy commitments. This engagement has recently extended into the domain of healthcare provision in the context of medical tourism.
Working with community researchers to enhance rural community engagement around Private Water Supplies: an exploration of the benefits and challenges
Authors: Creaney Rachel , Currie Mags , Teedon Paul , Helwig Karin
Published: December 2020

This project employed community researchers as a means of improving community engagement around their Private Water Supplies (PWS) in rural Scotland. In this paper, we reflect on working with community researchers in terms of the benefits and challenges of the approach for future rural research that seeks to improve community engagement. The paper (1) critiques the involvement of community researchers for rural community engagement, drawing on the experiences in this project and (2) provides suggestions for good practice for working with community researchers in rural communities’ research. We offer some context in terms of the role of community members in research, the importance of PWS, our approach to community researchers, followed by the methodological approach and findings and our conclusions to highlight that community researchers can be beneficial for enhancing community engagement, employability, and social capital. Future community researcher approaches need to be fully funded to ensure core researchers can fulfil their duty of care, which should not stop when data collection is finished. Community researchers need to be supported in two main ways: as continuing faces of the project after the official project end date and to transfer their newly acquired skills to future employment opportunities.
Using messy map interviews to describe and analyse elements pertinent to interviewees
Authors: Nordtug Maja
Published: December 2020

In this article, I introduce and evaluate the use of messy map interviews. Based on messy situational maps, messy map interviews is an interview tool I have developed to facilitate understanding of elements pertinent to interviewees. I present and evaluate how the tool contributes to interview studies that aim to describe and analyse elements pertinent to interviewees. This is done by use of an exemplar of working with messy map interviews, exploring parental decision-making about human papillomavirus vaccination. Based on the results, the study shows that messy map interviews can help keep qualitative research loyal to what interviewees ascribe relevance to. Furthermore, the tool can potentially help nuance the analysis of how elements are understood by interviewees. The article concludes that messy map interviews can be a useful mapping tool that keeps interviewees’ perspectives in focus in interview studies.
Negative effects of unlabeled response scales
Authors: Bergkvist Lars
Published: December 2020

This study used a novel research approach to investigate the effects of unlabeled response scales on response distributions. Instead of responding to standard questionnaire items respondents were asked to report given judgments on either semantic-differential (SD) or agree-disagree (AD) response scales, thereby showing the extent to which respondents agree upon where to place given judgments. Results from a survey-based study ( N = 418) show that respondents to a large extent disagree about where to place judgments on the response scale; the level of agreement for different judgment intensities ranged from 42% to 82% and the level of agreement is lower for AD than SD response scales. The low levels of agreement contribute to non-substantive variance in the data which increases the risk of attenuated or inflated correlations between constructs. Moreover, simulations of actual response distributions suggest that unlabeled response scales may lead to a strong bias in the form of underestimated shares of positive answers. Implications for research and marketing research practice of using unlabeled response scales are discussed and it is recommended that response categories on SD and AD items always should be labeled since this will reduce non-substantive variance and bias in the data.
Effect of occupational exposure to shock and vibration on health in high-performance marine craft occupants
Authors: de Alwis Manudul Pahansen , Garme Karl
Published: December 2020

Working conditions of High-performance Marine Craft (HPMC) occupants are inherent with shock and vibration. Therefore, HPMC occupants are usually investigated believing that their psychophysical health and performance are negatively affected by exposure to these conditions. However, the association between the regular occupational vibration exposures of HPMC occupants and the deterioration of their health and performance is disputable.

Therefore, a sample of HPMC occupants are investigated in a prospective cohort study by measuring perceived work exposure, health and performance via validated web-based questionnaires and physical work exposure as vibration using measurement systems installed onboard their craft. Incidence of musculoskeletal pain (MSP) during four operational seasons is determined and presented as incidence proportion (IP). Association between accumulated vibration exposure aboard HPMC and incidence of MSP is systematically assessed using multiple logistic regression models and expressed as odds ratio (OR). Moreover, the correlation between objectively and subjectively measured vibration exposures is determined using the Spearman’s rank correlation coefficient ( rs).

Incidence proportion of neck pain was 63.4% and that of lower back pain ranged from 12.5% to 87.5% over the four seasons. The accumulated vibration exposure was strongly associated with the incidence of MSP primarily with lower back pain. However, the association was not statistically significant. The objective and subjective vibration exposures of the craft drivers showed a statistically significant positive monotonic correlation.

The study suggests that occupational exposure to shock and vibration aboard HPMC is a factor increasing the incidence of MSP. The HPMC occupants regularly experience attrition in their performance. The perceived vibration exposure of the drivers can be used to rank the exposure severity aboard HPMC in the absence of objective measurements. The current vibration exposure assessment methods are also recommended to be revised accounting for shock and vibration inherent in HPMC exposures.
The financial management of cocaine trafficking in Italy
Authors: Terenghi Fiamma
Published: December 2020

Drawing on a set of empirical data, including in-depth interviews with law enforcers and public prosecutors, the article provides preliminary and detailed information on the structure, social organization of actors and financial management of cocaine trafficking in Italy. The article aims to increase knowledge on the financing mechanisms of organized crime activities and uses the Italian cocaine market as a case example. The findings suggest that the national market is fragmented into an interplay of actors who belong to upper, middle or low segments, depending on the level of the trafficking operations (that is, large, medium, small scale), that join as criminal networks to lower risks and maximize profits. These networks are mainly based on family, kinship or ethnic ties or relations built in other social/work settings. Cocaine trafficking operations are financed by both legal and illegal capital whose boundaries are blurred especially when organized crime groups are involved. Settlement of payments in cocaine trafficking operations reflects the level of trust between buyers and suppliers, with credit arrangements often set in longstanding business relationships or, at the other extreme, at the retail level to test clients’ reliability. The findings also add knowledge to existing research, improve the understanding and representation of organized crime, and contribute to enhance prevention and control activities of law enforcers, prosecutors and policy makers at the European and international level.
Application of a Body Map Tool to Enhance Discussion of Sexual Behavior in Women in South Africa, Uganda, and Zimbabwe
Authors: Naidoo Sarita , Duby Zoe , Hartmann Miriam , Musara Petina , Etima Juliane , Woeber Kubashni , Mensch Barbara S. , der Straten Ariane van , Montgomery Elizabeth T.
Published: December 2020

Body mapping methods are used in sexual and reproductive health studies to encourage candid discussion of sex and sexuality, pleasure and pain, sickness and health, and to understand individuals’ perceptions of their bodies. VOICE-D, a qualitative follow-up study to the VOICE trial, developed and used a body map tool in the context of individual in-depth interviews with women in South Africa, Uganda, and Zimbabwe. The tool showed the outline of a nude female figure from the front and back perspective. We asked women to identify, label, and discuss genitalia and other body parts associated with sexual behaviors, pain, and pleasure. Respondents could indicate body parts without having to verbalize potentially embarrassing anatomical terms, enabling interviewers to clarify ambiguous terminology that may have otherwise been open to misinterpretation. Body maps provided women with a non-intimidating way of discussing and disclosing their sexual practices, and minimized miscommunication of anatomical and behavioral terminology.
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment
Authors: Zhao ZhiYu , Liu Wei
Published: December 2020

This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of pancreatic cancer, and aims to promote further research on this under-studied malignant tumor. At present, we urgently need to identify high-risk patients with precancerous diseases through screening approaches, so that medical professionals and the general public may better understand prevention strategies or early detection measures. Pancreatic cancer is a highly invasive malignant tumor with a fatal risk, mainly seen in men and older adults (60-85 years old). Pancreatic cancer is now increasingly observed in young patients. Because the disease has no early symptoms and can quickly invade surrounding tissues and organs, it is one of the deadliest cancers. With a view to identify the important factors for the development of pancreatic cancer, previous studies have found that smoking, alcohol, and chronic pancreatitis are considered high-risk factors. Recent studies have shown that abnormal metabolism of human microorganisms, blood type, and glucose and lipid levels are also important factors in the development of pancreatic cancer. Identifying early diagnosis options is an important way to improve detection and survival rates of pancreatic cancer. None of the many tumor markers associated with pancreatic cancer are highly specific, which also indicates further research is required to improve the early detection rate. Future directions in terms of treatment evaluating the relationship between the microbiology-free system and immunotherapy will bring a major breakthrough and is expected to bring exciting clinical applications in improving the life-cycle of pancreatic cancer patients.
Comparative Analysis of the MRI Characteristics of Meningiomas According to the 2016 WHO Pathological Classification
Authors: Yu Juan , Chen Fan-fan , Zhang Han-wen , Zhang Hong , Luo Si-ping , Huang Guo-dong , Lin Fan , Lei Yi , Luo Liangping
Published: December 2020

Objects:

To evaluate the performance of preoperative magnetic resonance imaging (MRI) in evaluating diagnoses, operation methods and recurrence of meningiomas according to the World health organization (WHO) pathological classification.

Methods:

MRI characteristics of 127 meningioma patients were retrospectively analysed according to pathological results (WHO grade) and their association with Simpson’s grades (resection) and recurrence.

Results:

The T1-weighted imaging (T1WI) signal intensity of WHO grade I meningiomas was slightly hypointense or isointense gray, while the T2-weighted imaging (T2WI) signal intensity was isointense or slightly hyperintense. The T1WI and T2WI signal intensity in WHO grade II and III meningiomas was isointense gray. The enhancement degree and patterns, lobulation, flowing voids, dural tail, maximum diameter, peritumoural oedema, ADC values and margin were significantly different between any 2 grades (P < 0.05). The ADC values were higher for WHO grade I tumors than for WHO grade II and III tumors (P < 0.001). Among all the analyzed characteriscs, ADC values, peritumoural oedema, and margin effectively predicted the diagnosis according to the WHO classification. The operation method and surgical resection were different between WHO grade Ⅰ and WHO grade Ⅱ/Ⅲ meningiomas (P < 0.05). The recurrence rate increased with tumor grade, but there was no statistical difference among the 3 types(P> 0.05).

Conclusions:

WHO grades and pathological subtypes of meningiomas can generally be determined based on their MRI characteristics. In addition, MRI provides significant guidance for the grading of surgical success and prognosis.
The BRCA2 p.N372 H i.a.1342A>C Could Regulate the Sensitivity of Ovarian Cancer Cells to Platinum-Based Drugs
Authors: Du Zhen-Hua , Xia Yu , Yang Qing , Gao Song
Published: December 2020

Background and Objective:

We have previously reported that BRCA2 N372 H i.a.1342A>C heterozygous variation presented in platinum-resistant patients. This study aimed to further investigate the mechanism of BRCA2 N372 H mutation in the development of platinum resistance in ovarian cancer.

Methods:

The BRCA2 N372 H i.a.1342A>C was synthesized and used to exchange 1 wildtype allele followed by sequencing to confirm the mutant allele sequence. Plasmids were constructed and transfected into the OVCAR-3 cells after lentiviral packaging. BRCA2 N372 H mRNA was detected by qPCR. BRCA2 protein was assessed by immunoblotting. Binding of the BRCA2 to Rad51 was detected by immunofluorescence staining. Sensitivity of the cells to cisplatin treatment was assessed with CCK-8 assay.

Results:

It was found that expression of BRCA2 protein in ovarian cancer cells transfected with BRCA2 N372 H i.a.1342A>C gene (2.177 ± 0.003) was significantly increased compared to that of the cells transfected with lenti-EGFP only (1.227 ± 0.003, P < 0.001). Binding of the BRCA2 and Rad51 proteins was significantly increased in the cells with BRCA2 N372 H i.a.1342A>C mutation (3.542 ± 0.24) than that in the cells transfected with lenti-EGFP (1.29 ± 0.32) or empty cells (1.363 ± 0.32, P < 0.001). Cell viability significantly increased in the cells transfected with BRCA2 N372 H mutant gene. The IC50 value was significantly higher in the cells transfected with BRCA2 N372 H mutant gene (1.963 ± 0.04) than that of the cells transfected with lenti-EGFP (0.955 ± 0.03, P < 0.01) or empty cells (1.043 ± 0.007, P < 0.01).

Conclusion:

Over expression of mRNA and protein of BRCA2 was detected in the cells with BRCA2 N372 H i.a.1342A>C mutation but not in the lentivirus negative control (lenti-EGFP) or the cells without transfection (empty cells), which may lead to resistance to platinum-based drugs in ovarian cancer cells through homologous recombination repair pathway.
Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer
Authors: Yu Xiying , Teng Ying , Jiang Xingran , Yuan Hui , Jiang Wei
Published: December 2020

Background:

Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is involved in the maintenance of CSCs. However, the methylation profile of esophageal CSCs remains unknown.

Methods:

Side population (SP) cells were isolated from esophageal squamous cell carcinoma (ESCC) cell lines KYSE150 and EC109. Sphere-forming cells were collected from human primary esophageal cancer cells. SP cells and sphere-forming cells were used as substitutes for cancer stem-like cells. We investigated the genome-wide DNA methylation profile in esophageal cancer stem-like cells using reduced representation bisulfite sequencing (RRBS).

Results:

Methylated cytosine (mC) was found mostly in CpG dinucleotides, located mostly in the intronic, intergenic, and exonic regions. Forty intersected differentially methylated regions (DMRs) were identified in these 3 groups of samples. Thirteen differentially methylated genes with the same alteration trend were detected; these included OTX1, SPACA1, CD163L1, ST8SIA2, TECR, CADM3, GRM1, LRRK1, CHSY1, PROKR2, LINC00658, LOC100506688, and NKD2. DMRs covering ST8SIA2 and GRM1 were located in exons. These differentially methylated genes were involved in 10 categories of biological processes and 3 cell signaling pathways.

Conclusions:

When compared to non-CSCs, cancer stem-like cells have a differential methylation status, which provides an important biological base for understanding esophageal CSCs and developing therapeutic targets for esophageal cancer.
Transarterial Chemoembolization Followed by Radiotherapy Versus Sandwich Treatment for Unresectable or Ablative Hepatocellular Carcinoma
Authors: Lin Haimin , Wu Huiyong , Cong Ning , Liu Bo , Liu Chengxin , Han Dali
Published: December 2020

Objective:

Our objective is to assess whether the outcome of intrahepatic unresectable or ablative hepatocellular carcinoma (HCC) could be improved by supplemental transarterial chemoembolization (TACE) following initial treatment of TACE with 3-dimensional conformal radiotherapy (3DCRT), compared to TACE followed by 3DCRT alone.

Methods:

We retrospectively analyzed intrahepatic unresectable or ablative HCC patients who underwent TACE, followed by 3DCRT with or without additional TACE, from June 2010 to December 2016 at our institution. Survival was assessed using the Kaplan-Meier method and compared with the log-rank test. Cox regression analyses were used to identify factors that influenced prognosis. Toxicity profiles were evaluated using CTCAE 4.0.

Results:

27 patients received TACE with 3DCRT (TR group) and 11 received additional TACE following TACE and 3DCRT (sandwich group), respectively. The median intrahepatic progression-free survival (IPFS), progression-free survival (PFS), and overall survival (OS) in the TR group and sandwich group were 5.4 months vs. 17 months (P = 0.018), 5.4 months vs. 17 months (P = 0.008), and 13.5 months vs. 29.2 months (P = 0.011), respectively. Multivariate Cox regression demonstrated that TACE followed by radiotherapy alone had a shorter IPFS (HR: 2.516, 95% CI (1.136-5.570), P = 0.023) and PFS (HR: 2.637, 95% CI (1.182-5.880), P = 0.018) compared with the sandwich treatment. Hepatitis B virus reactivation occurred in 1 patient in the sandwich group. Myleosuppresion was considered a grade 3/4 adverse event.

Conclusion:

Unresectable or ablative HCC patients possibly benefit from the combination of TACE and 3DCRT followed by additional TACE therapy, compared with TACE followed by 3DCRT alone.
The Prevalence, Associated Factors for Lung Metastases Development and Prognosis in Ovarian Serous Cancer Based on SEER Database
Authors: Cao Chengcheng , Yang Xianghong
Published: December 2020

Ovarian carcinoma (OC) is one of the 3 most common gynecological malignancies, and the prognosis of patients with lung metastasis was the worst. SEER documented OC patients, diagnosed between 2010 and 2016, were included in the study. Univariable and multivariable logistic regression analyses were performed to identify associated factors for lung metastases (LM) development. Kaplan–Meier analysis was used to estimate the overall survival for OC patients with LM. A total of 10146 eligible serous ovarian cancer (SOC) patients were included, the prevalence of LM was 3.77% (N = 378). Patients with T4 stage (χ2 = 128.515; P = 0.000), N1 stage (χ2 = 49.536; P = 0.000), right laterality (χ2 = 18.756; P = 0.000) (compared with left side), undifferentiated grade (χ2 = 36.174; P = 0.000), bone metastasis (χ2 = 183.529); P = 0.000), brain metastasis (χ2 = 117.539; P = 0.000), liver metastasis (χ2 = 442.472; P = 0.000) had a larger probability of LM than other groups. Results showed that T3/N1 stage, bone metastases, liver metastases, chemotherapy, surgery were positively correlated with LM. Multivariable cox analysis showed that age, bone metastasis, no chemotherapy, no surgery were independent risk factors in SOC-LM patients. This study provided new research insights on the prevalent LM in patients with SOC. The factors associated with LM development and prognosis can be potentially used for LM early screening and professional care.
Quantitative PET Imaging and Clinical Parameters as Predictive Factors for Patients With Cervical Carcinoma: Implications of a Prediction Model Generated Using Multi-Objective Support Vector Machine Learning
Authors: Zhou Zhiguo , Maquilan Genevieve M. , Thomas Kimberly , Wachsmann Jason , Wang Jing , Folkert Michael R. , Albuquerque Kevin
Published: December 2020

Purpose:

Quantitative features from pre-treatment positron emission tomography (PET) have been used to predict treatment outcomes for patients with cervical carcinoma. The purpose of this study is to use quantitative PET imaging features and clinical parameters to construct a multi-objective machine learning predictive model.

Materials/Methods:

Seventy-five patients with stage IB2-IVA disease treated at our institution from 2009–2012 were analyzed. Models predicting locoregional and distant failure were generated using clinical parameters (age, race, stage, histology, tumor size, nodal status) and imaging features (12 textural, 9 intensity, 8 geometric features, 2 additional imaging features) from pre-treatment PET. Model features were selected based on a multi-objective evolutionary algorithm to maximize specificity given a fixed moderately high sensitivity using support vector machine learning methods. Model 1 used clinical parameters only (C), Model 2 used imaging features only (I), and Model 3 used clinical and imaging features (C+I). Sensitivity, specificity, area under a receiver-operating characteristic curve (AUC), and p-values were compared to assess ability to predict locoregional and distant failure.

Results:

C+I had the highest performance for both locoregional failure (AUC 0.84, p < 0.01; specificity: 0.86; sensitivity: 0.79) and distant failure (AUC 0.75, p < 0.01; specificity: 0.75; sensitivity: 0.75).

Conclusions:

Based on a moderately high fixed sensitivity and optimized for specificity, the model using both clinical parameters and imaging features (C+I) had the best performance in predicting both locoregional failure and distant failure.
Decreased Gamma Auditory Steady-State Response Is Associated With Impaired Real-World Functioning in Unmedicated Patients at Clinical High Risk for Psychosis
Authors: Ahmed Sarah , Lepock Jennifer R. , Mizrahi Romina , Bagby R. Michael , Gerritsen Cory J. , Korostil Michele , Light Gregory A. , Kiang Michael
Published: December 2020

Aim

Deficits in synchronous, gamma-frequency neural oscillations may contribute to schizophrenia patients’ real-world functional impairment and can be measured electroencephalographically using the auditory steady-state response (ASSR). Gamma ASSR deficits have been reported in schizophrenia patients and individuals at clinical high risk (CHR) for developing psychosis. We hypothesized that, in CHR patients, gamma ASSR would correlate with real-world functioning, consistent with a role for gamma synchrony deficits in functional impairment.

Methods

A total of 35 CHR patients rated on Global Functioning: Social and Role scales had EEG recorded while listening to 1-ms, 93-dB clicks presented at 40 Hz in 500-ms trains, in response to which 40-Hz evoked power and intertrial phase-locking factor (PLF) were measured.

Results

In CHR patients, lower 40-Hz PLF correlated with lower social functioning.

Conclusions

Gamma synchrony deficits may be a biomarker of real-world impairment at early stages of the schizophrenia disease trajectory.
“They Still Know I’m Their Momma”: Incarcerated Mothers’ Perceptions of Reunification and Resuming a Caregiver Role
Authors: Wilson Amber , Koons-Witt Barbara
Published: December 2020

Using in-depth interviews with mothers incarcerated in a maximum-security prison, the current study explores incarcerated mothers’ own perceptions and expectations regarding reunification with their families. For many of these mothers, reunification was an exciting prospect, but they recognized that the transition may not be easy for themselves, their children, or their children’s caregivers. Notably, while past research has treated reunification as including assuming care of children, our study suggests that some women view reunification strictly as rebuilding relationships with their children without plans to assume caring for them. We discuss implications for policy and programming for institutional and community corrections.
Protective Effect of S-Allyl Cysteine Against Neonatal Asthmatic Rats
Authors: Jiang Li , Li Yuning , Wang Fang , Zhang Xindao , Zhao Ruiping
Published: December 2020

S-Allyl cysteine (SAC), an organic compound and a natural constituent of Allium sativum, commonly known as garlic have been consumed in routine foods are known to possess various biological activities. Nevertheless, scientific evidence on the protective effect of SAC against neonatal asthmatic rats is not available. Hence, the present study aimed at investigating the anti-asthmatic activity of SAC in neonatal asthmatic rats using Wistar rats. The study conducted in 4 groups consists of normal control rats, asthma-induced, asthma animals administered with SAC (25 mg/kg), and SAC control. At the end of the experimental period, inflammatory cells in bronchoalveolar lavage fluid (BALF), inflammatory markers, fibrinogen level, activated partial thromboplastin time, coagulation factor activity, and histopathology were elucidated. The current investigation exhibits that SAC significantly reduced the total leukocytes, with restored fibrinogen level, and activated partial thromboplastin time. In addition, the levels of inflammatory cytokines such as TNF-α (tumor necrosis factor- α), IL-6 (Interleukin 6), and IL-1β have also attenuated in SAC treated animals. Furthermore, the mRNA expression levels of COX2 (cyclooxygenase-2), MCP-1 (monocyte chemoattractant protein-1), RANTES (regulated upon activation, normal T cell expressed and secreted), and eotaxin were reduced in SAC treated animals. Treatment of rats with SAC significantly reduced inflammation and eosinophil infiltration in the lungs. These results suggest that SAC exert protection in neonatal asthmatic rats suffering from acute or chronic inflammation by inducing anti-inflammatory and cell-protective responses.
Analytical model of high-frequency energy flow response for a beam with free layer damping
Authors: Teng Xiaoyan , Liu Nan , Jiang Xudong
Published: December 2020

Energy flow analysis (EFA) is developed to predict the vibrational energy density of beam structures with both full free layer damping (FFLD) and partial free layer damping (PFLD) treatments in the high frequency range. Both equivalent flexural stiffness and structural damping loss factor of a beam with free layer damping are obtained using the equivalent complex stiffness method. Then the energy density governing equation considering high damping effect is derived for a beam with FFLD treatment. Following obtainment of the energy transfer coefficients at both ends of free damping layer, the energy density within a beam with PFLD treatment is evaluated by solving the presented energy governing equation. To verify the proposed formulation, numerical simulations are performed for the pinned-pinned beams with FFLD and PFLD treatments. The EFA results are compared with the exact solutions from wave analysis at various frequencies, and good correlations are observed between the developed EFA results and the exact solutions.
A comparison of US and Scotland youth soccer coaches’ legal consciousness regarding concussion safety regulations
Authors: DeMartini Anne L , Kim Sungwon , Connaughton Daniel P , McArdle David
Published: December 2020

Due to the severe health consequences of sport related concussion (SRC), governments and sport governing bodies around the world have enacted numerous measures including changes to legislation and rules of the game, and increased emphasis on coach education. This study compared the legal consciousness of girls’ youth soccer coaches regarding concussion management under a statutory legal regime in the U.S. and a voluntary regime in Scotland by analyzing qualitative data through ten interviews of girls’ youth soccer coaches in Scotland and another ten interviews of girls’ high school soccer coaches in the U.S. Utilizing the socio-legal theory of legal consciousness, the findings support the idea that people make connections from their past experiences to shape their understanding of the law, broadly defined. We observed variance between U.S. and Scottish coaches’ legal consciousness. Overall, all coaches exhibited a version of conformity to and engagement with SRC management guidance and little resistance. Florida coaches displayed more conformity, likely due to the SRC education mandated by law. Scottish coaches who had coached in the U.S. previously demonstrated the strongest resistance. The findings suggest a need for continued improvement in the implementation of SRC laws and guidelines including updated training and better dissemination of educational materials.
Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation
Authors: dos Santos Tabata M. , Righetti Renato F. , Rezende Bianca G. , Campos Elaine C. , Camargo Leandro do N. , Saraiva-Romanholo Beatriz M. , Fukuzaki Silvia , Prado Carla M. , Leick Edna A. , Martins Milton A. , Tibério Iolanda F. L. C.
Published: December 2020

Background and aims:

Expansion and morphological dysregulation of the bronchial vascular network occurs in asthmatic airways. Interleukin (IL) -17 and Rho-kinase (ROCK) are known to act in inflammation control and remodeling. Modulation of Rho-kinase proteins and IL-17 may be a promising approach for the treatment of asthma through the control of angiogenesis. Our objective was to analyze the effects of treatment with anti-IL17 and/or Rho-kinase inhibitor on vascular changes in mice with chronic allergic pulmonary inflammation.

Methods:

Sixty-four BALB/c mice, with pulmonary inflammation induced by ovalbumin were treated with anti-IL17A (7.5/µg per dose, intraperitoneal) and/or Rho-kinase inhibitor (Y-27632-10 mg/kg, intranasal), 1 h before each ovalbumin challenge (22, 24, 26, and 28/days). Control animals were made to inhale saline. At the end of the protocol, lungs were removed, and morphometric analysis was performed to quantify vascular inflammatory, remodeling, and oxidative stress responses.

Results:

Anti-IL17 or Rho-kinase inhibitor reduced the number of CD4+, CD8+, dendritic cells, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, Rho-kinase 1 and 2, transforming growth factor (TGF-β), vascular endothelial growth factor (VEGF), nuclear factor (NF)-KappaB, iNOS, metalloproteinase (MMP)-9, MMP-12, metalloproteinase inhibitor-1 (TIMP-1), FOXP-3, signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1-positive cells, and actin, endothelin-1, isoprostane, biglycan, decorin, fibronectin and the collagen fibers volume fraction compared with the ovalbumin group ( p < 0.05). The combination treatment, when compared with anti-IL17, resulted in potentiation of decrease in the number of IL1β- and dendritic cells-positive cells. When we compared the OVA-RHO inhibitor-anti-IL17 with OVA-RHO inhibitor we found a reduction in the number of CD8+ and IL-17, TGF-β, and phospho-STAT1-positive cells and endothelin-1 in the vessels ( p < 0.05). There was an attenuation in the number of ROCK 2-positive cells in the group with the combined treatment when compared with anti-IL17 or Rho-kinase inhibitor-treated groups ( p < 0.05).

Conclusion:

We observed no difference in angiogenesis after treatment with Rho-kinase inhibitor and anti-IL17. Although the treatments did not show differences in angiogenesis, they showed differences in the markers involved in the angiogenesis process contributing to inflammation control and vascular remodeling. The reviews of this paper are available via the supplemental material section.
Marital status does not affect the cancer-specific survival of patients with upper tract urothelial carcinoma treated with nephroureterectomy: a propensity score matching study
Authors: Mao Weipu , Wu Jianping , Wang Keyi , Xu Bin , Chen Ming
Published: December 2020

Background:

The purpose of this study was to investigate the relationship between marital status and the prognosis of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy (NU).

Methods:

Patients with UTUC who received NU treatment were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. Kaplan–Meier curves and Cox regression were used to analyze the effect of marital status on cancer-specific survival (CSS), and 1:1 propensity score matching (PSM) was performed for married and unmarried patients to explore further the effect of marital status on patients with UTUC.

Results:

Among 1565 eligible patients, 960 (61.3%) were married and 605 (38.7%) were unmarried, of which 146 (9.3%) were divorced/separated, 306 (19.6%) were widowed, and 153 (9.8%) were single. Multivariate Cox regression analysis showed that marital status was not an independent risk factor for patients with UTUC treated with NU. After stratification by grade and SEER stage, multivariate analysis showed that there was no significant difference in 5-year CSS between divorced/separated, widowed, and single patients compared with married patients in different grades and SEER stages. In addition, after PSM analysis, marital status was still not an independent risk factor for patients with UTUC treated with NU.

Conclusion:

For patients with UTUC treated with NU, marital status has no prognostic effect on CSS.
Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis
Authors: Zhu Erjia , Dai Chenyang , Xie Huikang , Su Hang , Hu Xuefei , Li Ming , Fan Junqiang , Liu Jinshi , Zhu Quan , Zhang Lei , Ke Honggang , Chen Chang
Published: December 2020

Background:

Our aim was to investigate the prognostic impact of the lepidic component on T stage in patients with lung adenocarcinoma (LUAD).

Methods:

A retrospective data set including 863 cases of LUAD with lepidic component and 856 cases without lepidic component was used to identify matched lepidic-positive and lepidic-negative cohorts ( n = 376 patients per group) using a propensity-score matching. Primary outcome variables included recurrence-free survival (RFS) and overall survival (OS). Prognostic factors were assessed by Cox regression analysis and Kaplan–Meier estimates.

Results:

Multivariate analysis revealed that lepidic component presence was an independent prognostic factor for prolonged RFS ( p < 0.001) and OS ( p < 0.001). Furthermore, lepidic ratio (LR) >25% or ⩽25% were confirmed to be independent prolonged survival predictors. No survival differences were observed between patients with LUAD with LR >25% or ⩽25% (RFS p = 0.333; OS p = 0.078). The 5-year OS rates of patients with LUAD with a lepidic component were 90% regardless of the T stage, and these survival rates were significantly better than those of patients with LUAD without a lepidic component in the corresponding T stage. Multivariate analysis confirmed that T stage was associated with survival only in patients with LUAD without a lepidic component.

Conclusions:

Lepidic component presence identifies a LUAD subgroup with an excellent prognosis independent of the LR, pathological T classification. Considering the lepidic component presence may improve prognostic predictions for patients with LUAD.