bluuebunny/crossref_metadata_2025 huggingface dataset:
Anshen Buxin Liuwei Pill, a Mongolian Medicinal Formula, Could Protect H2O2-Induced H9c2 Myocardial Cell Injury by Suppressing Apoptosis, Calcium Channel Activation, and Oxidative Stress
Authors: Tong Hai-Ying , Dong Yue , Huang Xian-Ju , Murtaza Ghulam , Huang Yu-Jia , Sarfaraz Iqbal Muhammad
Published: January 2022

Background. Anshen Buxin Liuwei pill (ABLP) is a Mongolian medicinal formula which has a therapeutic effect on the symptoms such as coronary heart disease, angina pectoris, arrhythmia, depression and irritability, palpitation, and short breath. However, its bioactivity against cardiac injury remains unclear. Methods. The protective effect of ABLP was evaluated using H9c2 cells. Cell viability, intracellular Ca2+, reactive oxidative indices, and mitochondrial membrane potential (∆ψ) were assessed, respectively. The mRNA levels of Ca2+ channel-related genes (DHPR, RyR2, and SCN5A) and oxidative stress-related genes (Keap1, Nrf2, and HO-1) were measured by RT-PCR. Results. 0.5–50 μg/mL ABLP could significantly decrease H2O2-induced cell injury by suppressing cell necrosis/apoptosis and excess oxidative stress, ameliorating the collapse of ∆ψ, and reducing intracellular Ca2+ concentration. Furthermore, 0.5–50 μg/mL ABLP reversed H2O2-induced imbalance in the mRNA levels of DHPR, RyR2, SCN5A, Keap1, Nrf2, and HO-1 gene in H9c2 cells, which further illustrate the mechanism. Conclusion. ABLP provided protective and therapeutic benefits against H2O2-induced H9c2 cell injury, indicating that this formula can effectively treat coronary disease. In addition, the present study also provides an in-depth understanding of the pharmacological functions of ABLP, which may lead to further successful applications of Mongolian medicine.
Steroid-Responsive Post-Traumatic Persistent Neutrophilic Meningitis
Authors: Haddad Mahboubeh , Sheybani Fereshte , Olfati Nahid , Azhdari Yeganeh
Published: January 2022

Post-traumatic meningitis is a potentially fatal condition that presents as a diagnostic and therapeutic challenge. The vast majority of post-traumatic meningitides are caused by infectious pathogens, most commonly multi-drug-resistant (MDR) bacterial pathogens. However, aseptic meningitis occurs less frequently due to tissue response to injury or stimulation by noninfectious agents, such as blood breakdown products or chemicals. Here, we present a case of post-traumatic persistent neutrophilic meningitis who was found to be steroid responsive. Diagnostic evaluation in our patient did not reveal any infectious pathogen, and the patient did not respond to broad-spectrum antimicrobial treatment. We suggest that physicians who treat patients with post-traumatic meningitis should consider steroid-responsive post-traumatic persistent neutrophilic meningitis (SPNM) in the list of differential diagnosis particularly when no infectious etiology is found and the patient does not respond to empirical antimicrobial treatment. Brain injury-induced immune dysregulation causing exaggerated inflammatory reaction might play a role in the pathogenesis of SPNM; however, further neuropathological studies are absolutely necessary to evaluate and characterize trauma-induced immune dysregulation.
Evaluating Dental Faculty’s Perspective regarding Emergency Introduction of Online Teaching and Learning: Early Experience during COVID-19 Lockdown in United States
Authors: Gupta Aman , Janic Ana , Thomson Joshua
Published: January 2022

Objectives. The March 2020 lockdown mandated institution closures and forced educators to provide remote instruction. We intended to gain an in-depth and holistic understanding of dental faculty’s experience and perceptions during this mandatory shift. Insights were gathered in 6 key areas: prior remote instruction experience; magnitude of transition and frequency of instruction methods used; training received; preferred teaching methods based on how they promote student learning, interaction, engagement, and performance; social impact; and future of teaching. Methods. An anonymous QualtricsXM survey was distributed to all dental faculties at University of Detroit Mercy in May 2020. Data was collected over a three-week period and analyzed using Statistical Package for the Social Sciences (SPSS) Statistics 26 (IBM; Armonk, New York, USA). Pearson chi-squared test and Fisher’s exact test were used to evaluate categorical data. Results. Out of the 30 participants who transitioned to online remote instruction, 16 (53.3%) reported an age between 30 and 49 years and 14 (46.7%) reported ≥50 years of age. Our analysis revealed that faculty in 30–49-year age range had no prior online synchronous teaching experience. The transition was described as interesting, useful, time-consuming, and challenging. In-person live teaching received highest number of first place rankings (50%), and online asynchronous method received highest number of last place rankings (42.86%). Faculties in >50 year age range expressed maximum satisfaction with online small-group discussions, and those in 30–49 years age group were more satisfied with one-on-one online discussion. Conclusion. Our study finds that the faculty tends to gravitate to online methods that are similar to or mimic their past in-person teaching environment. Forced remote instruction gave new content delivery experiences to faculties of all ranges of age and experience in teaching. This exposure is likely to result in a more widespread adoption of a variety of instructional methods in future. Our study strongly suggests that traditional in-person instruction is the preferred method for delivery of content and is likely better for student learning. Majority of the faculties believed that the future of dental education would be a mix of both in-class and online instruction. In summer and fall 2021, our institution adopted hybrid, flexible models for didactic instruction to allow students the opportunity to digest content in their preferred method. Careful planning and systematic, continued training will be required to enhance technological skills and to incorporate newer models into didactic and clinical instruction. For the success of blended learning, courses will need redesigning of assessment methods, commitment, and support from administrators.
Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Authors: Lappin Katrina M. , Barros Eliana M. , Jhujh Satpal S. , Irwin Gareth W. , McMillan Hayley , Liberante Fabio G. , Latimer Cheryl , La Bonte Melissa J. , Mills Ken I. , Harkin D. Paul , Stewart Grant S. , Savage Kienan I.
Published: January 2022

Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonstrate that depletion of SF3B1 specifically compromises homologous recombination (HR) and is epistatic with loss of BRCA1. More importantly, the most prevalent cancer-associated mutation in SF3B1, K700E, also affects HR efficiency and as a consequence, increases the cellular sensitivity to ionizing radiation and a variety of chemotherapeutic agents, including PARP inhibitors. In addition, the SF3B1 K700E mutation induced unscheduled R-loop formation, replication fork stalling, increased fork degradation, and defective replication fork restart. Taken together, these data suggest that tumor-associated mutations in SF3B1 induce a BRCA-like cellular phenotype that confers synthetic lethality to DNA-damaging agents and PARP inhibitors, which can be exploited therapeutically.

Significance:

The cancer-associated SF3B1K700E mutation induces DNA damage via generation of genotoxic R-loops and stalled replication forks, defective homologous recombination, and increased replication fork degradation, which can be targeted with PARP inhibitors.
Accounting for EGFR Mutations in Epidemiologic Analyses of Non–Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data
Authors: Schmid Sabine , Jiang Mei , Brown M. Catherine , Fares Aline , Garcia Miguel , Soriano Joelle , Dong Mei , Thomas Sera , Kohno Takashi , Leal Leticia Ferro , Diao Nancy , Xie Juntao , Wang Zhichao , Zaridze David , Holcatova Ivana , Lissowska Jolanta , Świątkowska Beata , Mates Dana , Savic Milan , Wenzlaff Angela S. , Harris Curtis C. , Caporaso Neil E. , Ma Hongxia , Fernandez-Tardon Guillermo , Barnett Matthew J. , Goodman Gary , Davies Michael P.A. , Pérez-Ríos Mónica , Taylor Fiona , Duell Eric J. , Schoettker Ben , Brenner Hermann , Andrew Angeline , Cox Angela , Ruano-Ravina Alberto , Field John K. , Marchand Loic Le , Wang Ying , Chen Chu , Tardon Adonina , Shete Sanjay , Schabath Matthew B. , Shen Hongbing , Landi Maria Teresa , Ryan Brid M. , Schwartz Ann G. , Qi Lihong , Sakoda Lori C. , Brennan Paul , Yang Ping , Zhang Jie , Christiani David C. , Reis Rui Manuel , Shiraishi Kouya , Hung Rayjean J. , Xu Wei , Liu Geoffrey
Published: January 2022

Background:

Somatic EGFR mutations define a subset of non–small cell lung cancers (NSCLC) that have clinical impact on NSCLC risk and outcome. However, EGFR-mutation-status is often missing in epidemiologic datasets. We developed and tested pragmatic approaches to account for EGFR-mutation-status based on variables commonly included in epidemiologic datasets and evaluated the clinical utility of these approaches.

Methods:

Through analysis of the International Lung Cancer Consortium (ILCCO) epidemiologic datasets, we developed a regression model for EGFR-status; we then applied a clinical-restriction approach using the optimal cut-point, and a second epidemiologic, multiple imputation approach to ILCCO survival analyses that did and did not account for EGFR-status.

Results:

Of 35,356 ILCCO patients with NSCLC, EGFR-mutation-status was available in 4,231 patients. A model regressing known EGFR-mutation-status on clinical and demographic variables achieved a concordance index of 0.75 (95% CI, 0.74–0.77) in the training and 0.77 (95% CI, 0.74–0.79) in the testing dataset. At an optimal cut-point of probability-score = 0.335, sensitivity = 69% and specificity = 72.5% for determining EGFR-wildtype status. In both restriction-based and imputation-based regression analyses of the individual roles of BMI on overall survival of patients with NSCLC, similar results were observed between overall and EGFR-mutation-negative cohort analyses of patients of all ancestries. However, our approach identified some differences: EGFR-mutated Asian patients did not incur a survival benefit from being obese, as observed in EGFR-wildtype Asian patients.

Conclusions:

We introduce a pragmatic method to evaluate the potential impact of EGFR-status on epidemiological analyses of NSCLC.

Impact:

The proposed method is generalizable in the common occurrence in which EGFR-status data are missing.
Impact of a Human Papillomavirus Vaccination Program within Organized Cervical Cancer Screening: Cohort Study
Authors: Martellucci Cecilia Acuti , Morettini Margherita , Brotherton Julia M.L. , Canfell Karen , Manzoli Lamberto , Flacco Maria Elena , Palmer Matthew , Rossi Paolo Giorgi , Martellucci Mosè , Giacomini Giusi , D'Errico Marcello Mario , Pasqualini Francesca
Published: January 2022

Background:

We assessed the effectiveness of an HPV (human papillomavirus) vaccination program in lowering cervical abnormality risk, and conferring herd protection.

Methods:

Retrospective cohort study using linked screening and vaccination administrative health data of the general population of Ancona Province, Italy. We included all female residents born in 1990–1993, eligible for catch-up HPV vaccination up to age 25 years, and adhering to organized screening in 2015–2020 (n = 4,665). Cervical abnormalities rates were compared between: Vaccinated and unvaccinated women, and cohorts with high and low vaccination uptake. Analyses were adjusted for age, country of birth, screening tests number, laboratory, and municipality average income. Main outcomes were ASC-US+ or LSIL+ Pap smears, and CIN1+ or CIN2+ histology.

Results:

Mean screening age was 26.6±1.5 years, and 1,118 screened women (24.0%) were vaccinated (mean vaccination age 19.2±1.5 years). The diagnosed cervical abnormalities were: 107 LSIL+ (2.3%), 70 CIN1+ (1.5%), and 35 CIN2+ (0.8%). The adjusted odds ratios of LSIL+, CIN1+, and CIN2+ among vaccinated versus unvaccinated women were, respectively: 0.55 [(95% confidence interval (CI), 0.33–0.91)], 0.43 (95% CI, 0.22–0.86), and 0.31 (95% CI, 0.11–0.91). Among the unvaccinated, those in the highest-uptake (45.3%) 1993 cohort, versus the last pre-vaccination 1990 cohort, showed AORs of LSIL+ and CIN1+ of 0.23 (95% CI, 0.10–0.50), and 0.22 (95% CI, 0.07–0.69), respectively.

Conclusions:

In the first evaluation from Central Italy, catch-up HPV vaccination considerably reduced the risk of all cervical abnormalities diagnosed within organized screening, and conferred an elevated degree of herd protection among unvaccinated women.

Impact:

The high protection conferred by HPV vaccination suggests the need to update cervical screening.
Assessment of Prophylactic Carbapenem Antibiotics Administration for Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis
Authors: Guo Daxin , Dai Wei , Shen Jingyi , Zhang Mengting , Shi Yetan , Jiang Ke , Guo Luyong
Published: January 2022

Background: The effectiveness of prophylactic antibiotics in severe acute pancreatitis (SAP) remains a debatable issue. This meta-analysis aimed to determine the efficacy of prophylactic carbapenem antibiotics in SAP. Methods: This meta-analysis of prophylactic carbapenem antibiotics for SAP was conducted in PubMed, EMBASE, Web of Science, MEDLINE, and Cochrane Library up to February 2021. The related bibliographies were manually searched. The primary outcomes involved infected pancreatic or peripancreatic necrosis, mortality, complications, infections, and organ failure. Results: Seven articles comprised 5 randomized controlled trials and 2 retrospective observational studies, including 3,864 SAP participants. Prophylactic carbapenem antibiotics in SAP were associated with a statistically significant reduction in the incidence of infections (odds ratio [OR]: 0.27; p = 0.03) and complications (OR: 0.48; p = 0.009). Nevertheless, no statistically significant difference was demonstrated in the incidence of infected pancreatic or peripancreatic necrosis (OR: 0.74; p = 0.24), mortality (OR: 0.69; p = 0.17), extrapancreatic infection (OR: 0.64, p = 0.54), pulmonary infection (OR: 1.23; p = 0.69), blood infection (OR: 0.60; p = 0.35), urinary tract infection (OR: 0.97; p = 0.97), pancreatic pseudocyst (OR: 0.59; p = 0.28), fluid collection (OR: 0.91; p = 0.76), organ failure (OR: 0.63; p = 0.19), acute respiratory distress syndrome (OR: 0.80; p = 0.61), surgical intervention (OR: 0.97; p = 0.93), dialysis (OR: 2.34; p = 0.57), use of respirator or ventilator (OR: 1.90; p = 0.40), intensive care unit treatment (OR: 2.97; p = 0.18), and additional antibiotics (OR: 0.59; p = 0.28) between the experimental and control groups. Conclusions: It is not recommended to administer routine prophylactic carbapenem antibiotics in SAP.
The Possible Pathogenic Role of IgG4-Producing Plasmablasts in Stricturing Crohn’s Disease
Authors: Bushara Omar , Escobar David Joseph , Weinberg Samuel Edward , Sun Leyu , Liao Jie , Yang Guang-Yu
Published: January 2022

Background: Crohn’s disease (CD) is a condition on the spectrum of inflammatory bowel disease that affects up to 20 people per 100,000 in the US annually, and with incidence increasing. One of the most significant sources of morbidity in CD is the formation of strictures, with resultant intestinal blockage a common indication for hospitalization and surgical intervention in these patients. The pathophysiology of stricture formation is not fully understood. However, the fibroplasia that leads to fibrostenotic stricture formation may have shared pathophysiology with IgG4-related fibrosis. Summary: Initial intestinal inflammation recruits innate immune cells, such as neutrophils, that secrete IL-1β and IL-23, which induces a type 17 CD4+ T-helper T-cell (Th17)-mediated adaptive immune response. These CD4+ Th17 T cells also contribute to inflammation by secreting proinflammatory cytokines such as IL-17 and IL-21. IL-21 recruits and stimulates CD4+ T follicular helper (Tfh) cells, which secrete more IL-21. This causes ectopic germinal center formation, recruiting and stimulating naïve B cells. The IL-17 and IL-21 produced by Th17 cells and Tfh cells also induce IgG4 plasmablast differentiation. Finally, these IgG4-producing plasmablasts secrete platelet-derived growth factor (PDGF), which activates local PDGF-receptor expressing fibroblasts and myofibroblasts, resulting in uncontrolled fibroplasia.
Pathological Laughter Prodromal to a Stroke of the Head of the Left Caudate Nucleus
Authors: Beth Urhoy Matthew , House William J.
Published: January 2022

A 38-year-old right-handed female with a past history of intermittent painful rash, dizzy spells, and chronic daily headaches as well as episodic migraines experienced an episode of transient involuntary pathological laughter, right arm weakness, and expressive dysphasia. She was found on MRI to have multiple strokes in multiple vascular distributions, including one in the head of the left caudate. A cardiac ECHO found an atrial myxoma, with extensive evaluation for other causes of stroke unrevealing. The differential diagnosis for pathological laughter in this patient is discussed. The most plausible cause in this patient is an infarct to the head of the left caudate nucleus caused by an embolus of the atrial myxoma.
The Hypothesis of Subliminal Cue Reactivity in Addiction Revisited: An fMRI Study
Authors: Guterstam Joar , Jayaram-Lindström Nitya , Berrebi Jonathan , Petrovic Predrag , Ingvar Martin , Fransson Peter , Franck Johan
Published: January 2022

Introduction: Exposure to conditioned cues is a common trigger of relapse in addiction. It has been suggested that such cues can activate motivationally relevant neurocircuitry in individuals with substance use disorders even without being consciously perceived. We aimed to see if this could be replicated in a sample with severe amphetamine use disorder and a control group of healthy subjects. Methods: We used fMRI to test the hypothesis that individuals with amphetamine use disorder, but not healthy controls, exhibit a specific neural reactivity to subliminally presented pictures related to amphetamine use. Twenty-four amphetamine users and 25 healthy controls were recruited and left data of sufficient quality to be included in the final analysis. All subjects were exposed to drug-related and neutral pictures of short duration (13.3 ms), followed by a backward visual mask image. The contrast of interest was drug versus neutral subliminal pictures. Results: There were no statistically significant differences in BOLD signal between the drug and neutral cues, neither in the limbic regions of primary interest nor in exploratory whole-brain analyses. The same results were found both in amphetamine users and controls. Discussion/Conclusion: We found no evidence of neural reactivity to subliminally presented drug cues in this sample of subjects with severe amphetamine dependence. These results are discussed in relation to the earlier literature, and the evidence for subliminal drug cue reactivity in substance use disorders is questioned.
Serum Potassium Disorders Predict Subsequent Kidney Injury: A Retrospective Observational Cohort Study of Hospitalized Patients
Authors: Lombardi Gianmarco , Gambaro Giovanni , Ferraro Pietro Manuel
Published: January 2022

Introduction: Electrolyte disorders are common findings in kidney diseases and might represent a useful biomarker preceding kidney injury. Serum potassium [K+] imbalance is still poorly investigated for association with acute kidney injury (AKI), and most evidence came from intensive care units. The aim of our study was to comprehensively investigate this association in a large, unselected cohort of hospitalized patients. Methods: We performed a retrospective observational cohort study on the inpatient population admitted to Fondazione Policlinico Universitario A. Gemelli IRCCS between January 1, 2010 and December 31, 2014, with inclusion of adult patients with at least 2 [K+] and 3 serum creatinine measurements who did not develop AKI during an initial 10-day window. The outcome of interest was in-hospital AKI. The exposures of interest were [K+] fluctuations and hypo (HoK) and hyperkalemia (HerK). [K+] variability was evaluated using the coefficient of variation. Cox proportional hazards regression models were used to obtain hazard ratios and 95% confidence intervals of the association between the exposures of interest and development of AKI. Results: About 21,830 hospital admissions from 18,836 patients were included in our study. During a median follow-up of 5 (interquartile range [IQR] 7) days, AKI was observed in 555 hospital admissions (2.9%); median time for AKI development was 5 (IQR 7) days. Higher [K+] variability was independently associated with increased risk of AKI with a statistically significant linear trend across groups (p value = 0.012). A significantly higher incidence of AKI was documented in patients with HerK compared with normokalemia. No statistically significant difference was observed between HoK and HerK (p value = 0.92). Conclusion: [K+] abnormalities including fluctuations even within the normal range are associated with development of AKI.
Network Security Using Honeypot and Attack Detection with Android Application
Authors: Panduardi Farizqi , Herman Yuliandoko  , Agus Priyo Utomo
Published: January 2022

Network security is now increasingly needed in the era of the industrial revolution 4.0. As technology grows, cybercrimes are becoming more and more common, including attacks on a resource. At this time, honeypots are also widely used by large industries for network security, besides that honeypots are also useful for them in developing intrusion and preventing systems. Honeypots are usually used in a virtual environment, they will stimulate a fake system to capture data packets on the network and be analysed offline later for all threats and attacks.

This propose of this paper is to detect and prevent building attacks from computer network attackers using an android application. This application can monitor an attack on the server by installing a honeypot tool into the server as an attack detector, then the honeypot log is used as a Rest API using Django framework with MongoDB database. this application can find out if there is an attack on the server, and can block the attacker's IP address.
EmbrASD: Android Mobile Application for Children with Autism as a Supplemental Tool for Therapy
Authors: Ignacio Aris E. , Ligot Mark Angelo A.
Published: January 2022

Autism has a very wide range that influences people, specifically children in general. Usually, it affects a child’s social interaction, communication, behaviors, and interests. Providing a complete device for treatment which is planned to be used by kids with autism needs to be taken into consideration. There is no software available that will adhere to the main areas of autism. The development a multidimensional software that focuses the main areas of kids with autism was a specific goal that the paper is being addressed. It is planned from the viewpoint of several specialists: more particularly speech therapist, occupational therapist, Special Education (SPED) educator and an Applied Behavior Analysis (ABA) specialist. The specialists’ focused objectives were lengthily included into the planning of the software. The development of an application for the young with autism that would completely attend to all the main areas that are initiated by autism and serves as an addendum to treatment is the primary goal of the study. Interviews from, speech therapist, occupational therapist, SPED teacher, ABA therapist and a SPED therapist will serve as a basis and the prototyping methodology for system development. With the implemented system, the intended users gave an approval on the application to be integrated in the teaching of children with autism. Suggestions on the improvement of the application comprises of including video recording for API 22, implementing the system in the iOS environment, and concentration on older autism cases were recommended.
The Shifting Role of Accountants in the Era of Digital Disruption
Authors: Mujiono Mia Novinda
Published: January 2022

Pandemic and industrial revolution 4.0 made almost of all business activities and professional moved to digital way. People have to adapted to work with many innovations that emerged in the field of business which they work, including accountant. The era of digital disruption made the fundamental role of the accountant taken over by system or software. This phenomenon raises anxiety for a number of accountants, because their jobs are replaced by system, so companies can reduce the number of workers which classified as accountants. Whether the accountant will die along with the development of technological innovation? Certainly not. The purpose of this research is giving insight that accountants are required to be agile-learners who enrich skills with the aim of managing creativity and reasoning so that they are able to create infrastructure, platforms, and digital software that can control the automation in business. Using qualitative explanatory research method with literature review, observation, and interview, researcher found that the functional role of accountants is increasing, not only in financial reporting system proficiency, but especially in strategic business analysts with the help of business intelligence as the basis of decision making for business. Likewise technological innovation gave birth to another scientific field of business and accountant which enlarge job opportunities and threats as the results and implications. Keeping financial data and confidential information safe and secure should be the top priority for any business.
Multicultural and Diversity Management in Higher Education Institutions in the Philippines
Authors: Llantos Elvira
Published: January 2022

The multicultural and diversity management (MDM) encompasses acceptance and respect, recognition and valuing of individual differences of the university stakeholders. This study determined the perceptions of the academic managers/ leaders towards multicultural and diversity management in a higher education institutions. This quantitative descriptive research determined the perceptions of 100 purposively selected academic managers/ leaders of selected higher education institutions in the Philippines. The researcher-designed questionnaire was administered online using Google Form. Data were analysed using frequency, percentage distribution, mean, and rank. The majority of the respondents belonged to the age group of 41- 50 years old. The respondents were dominated by males and were single. In terms of highest educational attainment, the majority of the respondents have a master’s degree with 1- 10 years of work experience. The majority of the respondents were Coordinators/Program Chairs who were Regular/Permanent employees. On the basis of the findings of the study, it can be gleaned that the majority of the respondents believed that multiculturalism and diversity management (MDM) in higher education institutions should be integrated with the human resources programs to improve the lenses of equality in the universities and colleges as a workplace. Most of them believe that the MDM program prepares employees for higher diversity in their team, as such; it helps in welcoming recruits with diverse backgrounds into the academic community and promotes a positive organizational culture. Respondents also believed that multicultural and diversity management in Higher Education Institution is one of the best ways that university employees and students can become accustomed to other cultures, nonjudgmental, respectful, and accepting of differences, receptive to different ways of thinking.
Phenomenological Synthesis of Cultural Understanding Among Senior High School Research Classes
Authors: Adlit Marlon F.
Published: January 2022

The development of student's skills in the conduct of research, both qualitative and quantitative, is envisioned in the K to12 curriculum. This study uses qualitative research to show students' perceptions and understanding of a particular issue. Similarly, it describes apparent cultures postulated within the students' chosen themes. Finally, it determines the development of cultural knowledge in the context of Merleau-Ponty's phenomenology of perception among Grade 11 students at a Senior High School near Laguna Lake in the City of San Pedro, Laguna, Philippines, during the school year 2016-2017. Semi-structured interviews, focus group discussions, and triangulation was used to obtain students' cultural understanding and share their experiences undertaking diverse qualitative research using purposive sampling. The data was analyzed using phenomenological analysis. Students' perceptions and streams of consciousness include street children, child labor fishermen, and school violence. Cultural understanding encompasses (a) the economic and psychological implications of family, (2) camaraderie, pakikisama and pakikiisa, and (3) education as a survival strategy. Senior High School students' research experiences connect underpinnings of cultural understanding.
Improving the Level of Economic Development and Social Welfare in Rural Areas for Young People
Authors: Jafarli Fuad
Published: January 2022

One of the three global goals set by states is to eradicate poverty and ensure economic and social progress for all.

Young people in many low- and middle-income countries face exceptional challenges in finding their place in a globalizing economy. Integrating hundreds of millions of young people into the labor market is one of the greatest global development challenges for decades to come. Rural populations all over the world are aging. The role of young people as drivers of change in agricultural and food systems and their place in rural labor markets is receiving increasing attention at the global level, especially as a result of increased global migration flows. How can this problem be transformed into a “youth” driving force for rural development?

This paper argues for leveraging growing demand for agricultural products and recent advances in the agricultural sector to expand youth employment opportunities and promote attractive decent jobs, especially green jobs, in rural areas.

The paper analyses the situation in our daily life, in which the proportion of the worldwide countries are dealing with the problem related to the economic development and social welfare in rural areas. The paper includes the following issues such as the attractiveness and creation of opportunities for youth and consideration of them as the main partners in rural areas play a crucial role nowadays. Moreover, green jobs as well are effective and efficient in enhancement of both productivity and sustainability of agricultural sphere. The question is how to transform this challenge into an opportunity and harness the energy of young people as a driving force for development. The role of young people as drivers of change in agro-food systems and their place in rural labor markets is receiving increasing attention at the global level, especially as a result of increased global migration flows.

A top priority for developed and developing countries is to systematically mainstream youth rural decent employment issues into programs and investment projects in agriculture, value chains, agro-industry development, rural transformation, and sustainable food systems. This paper argues for expanding employment opportunities for youth through the creation of decent jobs, especially green jobs, in rural areas.
Difficulties of Quality Education in Higher Education in India
Authors: Raja Piyush , Rahman M. M.
Published: January 2022

Higher education will lead the world in 21st era because it not only creates greater personal and social prosperity, but it also affects all facets of development, including intellectual, social, cultural, aesthetic, physical, spiritual, and human capital development, directly or indirectly. Afterward, US and China, India has the world's third largest higher education system. University Grants Commission (UGC) is the largest regulatory body at the higher level, and it enforces its guidelines, advises the administration, and facilitates communication between the federal government and the states. The University Grants Commission oversees accreditation for higher education by 15 independent institutions. While the nation has progressed significantly in terms of enrolment, the standard of education continues to be a source of concern, which is critical for achieving the country's goals and implementing national policy. Weak facilities, exam-driven curriculum, memory-based exams, a shortage of qualified faculty, ineffective teaching strategies, a lack of funding, inconsistencies in government policy on higher education, entrenched political motives, massive demands from the youth population, political unrest, increasing privatisation, a lack of access and equity, and so on are some of the problems in higher education. There are several more problems like this, and this paper objectively examines all of them, as well as potential solutions.
Integrating Project-based Activity in Improving the Science Academic Performance of Learners in the New Normal
Authors: Solis Jeanette Mamaril
Published: January 2022

The objective of this paper was to determine the efficacy of Project-based learning in increasing the academic performance of learners in remote learning amidst the pandemic. There were eight (8) Project-based instructional activities across six (6) most essential learning competencies in Earth Science were included in the Grade 9 Unit three Earth Science. The computed t value of 5.08 is greater than the t critical value of 2.0049 at level of significance of 0.05, the statistical decision is to reject the null hypothesis. There is a significant difference between the pre-test and post-test of the respondents who were subjected to project-based activity. Result implied that there is enough evidence to support the claim that integrating project-based activity can effectively improve the academic performance of the respondents. Based on the analysis gathered by the researcher, the use of project-based activity in on-line teaching is highly effective in improving the academic performance of students in Earth Science. Therefore, I, the researcher, recommends the use of project-based method of teaching in the on-line distance learning.
Performance Assessment Task: A Point of Reference for Science Teachers - this Pandemic and Beyond
Authors: Sabijon Jr. Ananias C.
Published: January 2022

The pursuit for quality education, including that in the basic education levels, for sustainable development is clearly described in the Education for Sustainable Development (ESD), one of the17 Sustainable Development Goals (SDGs) by the UN. Accordingly, to equip students, with knowledge, skills, attitudes, and values they'll need to face the difficulties along with sustainable development, there is a need to update some processes currently utilized in science teaching and learning. For this reason, alternative activities and assessment methods, like the use of performance task assessment is needed to improve both the quality of teaching and to provide a meaningful learning experience to students. The purpose of this study was to provide relevant information from extant literature and a sample performance task assessment to encourage Science teachers to utilize these information in their classes. To achieve this purpose, significant information about performance task assessment and an original performance task assessment were presented. The use of performance assessment task is one alternative method to develop critical thinking skills, and to provide an education that is truly relevant to every student in the light of today’s challenges, like the pandemic. It could provide authentic and meaningful learning experience to students, and is very relevant in the context of coping with the challenges the science teachers have been facing. With the many pieces of evidence on its effectiveness and positive learning experience by students provided by literature, it is certain that the use of performance assessment task in Science classes cannot be overemphasized.
Coping Mechanisms of Hospitality Industry Workers in a Tourism Destina-tion during the Covid-19 Pandemic
Authors: Danay Bezaleel Joy Murchante , Danay Zephaniah Dela Cruz , Escarilla Cherry Colesio , Maming Jimmy Bernabe
Published: January 2022

The Covid-19 pandemic brought massive devastations to the different levels of society. The World Travel and Tourism Council had recently warned that Covid-19 pandemic could lead to a cut of 50 million jobs worldwide in the travel and tourism industry. A study conducted by Oxford reveals that Asia will be vilest to be affected by the pandemic and it would take time to recover its economy (Dogra, 2020). This means a wider and greater impacts to the different industries including the tourism sector. The study aims to explore the coping mechanisms of hospitality industry workers in Boracay Island during the Covid-19 pandemic particularly on their experiences during the Covid-19 pandemic and to determine the coping mechanisms of hospitality workers in Boracay Island being affected by the pandemic. The case study method through a qualitative analysis using Robert Yin's approach in the data analysis procedure to explore the data from the experiences of the key informants from the hospitality industry was used. Themes came out from the construct of the key informants like (1) hospitality industry workers experienced mental health, social, and economic issues, (2) The pandemic opens new opportunities and ways to cope with its effects. The output of this research is the proposed Danay, Danay, Escarilla, and Maming Model for Coping Mechanisms of Hospitality Industry workers during the Covid-19 Pandemic.
Strategies and Approaches in Teaching Values Education Among Public Secondary School In The Division Of Zambales
Authors: Edaño Domingo C. , Meer Christine Joy Q.
Published: January 2022

ABSTRACT

 

The research aimed to look into the strategies and approaches in teaching values education among public secondary schools in the Division of Zambales, SY 2020-2021. The researcher used the quantitative descriptive-survey research design with questionnaire as the main instrument in gathering data from the population of three hundred (300) values educational teacher.

The study revealed that the majority of Values Education teachers are female. The teachers always used Inculcation Approach as strategy in teaching Values Education. The respondents strongly agreed that the strategies in teaching Values Education was the most difficult dimension in teaching Values Education. There is significant differences on age and religious affiliation towards inculcation approach and significant on age towards Awareness Approach. No significant differences on moral reasoning approach, value clarification approach and evocation approach. Moreover, it was found that there is significant difference on age towards difficulty on contents while no significant differences on strategies and assessment respectively. There is negligible relationship between the academic performance and the strategies and approaches used in teaching values education. There is negligible relationship between the academic performance and the difficulties in teaching Values Education.

The training design is hereby proposed entitled: Training Design in Values Education on Teaching Strategies and Approaches Amidst COVID 19-Pandemic.

Based on the salient findings, the researcher recommended that head teachers and teachers in Values Education should make innovations on how Inculcation Approach in teaching the subject be more useful and effective; head teachers, principals, education specialist on Values Education of Division of Zambales may focus their In-service Trainings ways how teachers enhance the utilization and effectiveness of approaches; the teachers should look and utilize suitable techniques for Inculcation, Moral Reasoning, Awareness, Value Clarification and Evocation approaches; and head teachers and teachers are encouraged to attend national and international trainings and seminars for better understanding and improved skill in selecting appropriate strategies, on the development of learning content and assessment procedures in Values Education.
Existence of Female Journalists Wearing Jilbab in the Television Media Jakarta
Authors: Rabathy Qisthy , Komala Elly , Susila Trisnawati Yanti , Fadlah Nik
Published: January 2022

Female who wear jilbab is now choosing journalists as a job. Journalists are a job which exists in the middle of the community who is assigned to provide information or news to the public. This is a very heavy profession and not everyone can do this profession. Uncertain journalist working hours added with various difficulties and obstacles in this profession make this profession identified as a male profession. This becomes a challenge for journalists wearing jilbab who choose this job as their profession
Symbolic Interaction Of Migrant Women In Pontang District, Banten Province
Authors: Mulyasih Rahmi , Sihabudin Ahmad , Faiz Fahruddin
Published: January 2022

Migrant women are a phenomenon that describes a change in the position of husband and wife in the life of Indonesian society in general. This study aims to explore the interactions that occur between migrant women and their families and communities which then lead to symbols that are interpreted differently by migrant women, families and communities. The research method used in this study uses an ethnomethodological method, which in this research method reflects behavior and tries to understand or interpret someone and others. The results of the study illustrate that there are symbols that are interpreted as meaning the success of migrant women with big and nice houses, jewelry worn and vehicles. These symbols then create a new culture or different interactions between migrant women, both with their families and communities.
Financial Statement Model Based on SAK EMKM In The “Polife” Student Entrepreneur Group
Authors: Kumaat Lusye Corvanty , Paendong Yelly Sjenny , Lintong Jerry Sonny
Published: January 2022

The purpose of this research is to create a Financial Report Model based on SAK-EMKM in the Student Entrepreneurial Group "PROLIFE" in Manado City, North Sulawesi Province. The ratio of the number of entrepreneurs or entrepreneurs in Indonesia is currently only 2 percent of the total population. Ideally, the ratio of entrepreneurs is 4 percent in order to encourage national economic growth. The POLIFE student entrepreneurial group is part of the Student Entrepreneurship Program (SEP) which is a program initiated by the Ministry of Education and Culture of the Republic of Indonesia, to be developed into campus life in order to stimulate the entrepreneurial spirit of students. As an entity, the manager is obliged to prepare financial reports, which will be used by interested parties in making decisions. To help MSMEs meet their financial reporting needs, the Indonesian Institute of Accountants' Financial Accounting Standards Board has compiled and ratified SAK EMKM. Financial reports based on SAK EMKM, which Polife must prepare, consist of a statement of financial position, an income statement, and notes to financial statements.
Espinosa de preciado: potência de agir como Potentia Gaudendi
Authors: Munchow Cleiton
Published: January 2022

Objetivamos investigar a relação entre o pensamento de Espinosa e o de Preciado a partir do uso que o segundo faz, ao longo de sua obra, da filosofia do primeiro. O objetivo geral ramifica-se na investigação dos conceitos colocados em operação no processo de ativação conceitual empreendido por Preciado. Potência de agir ou força de existir, multidão, servidão e liberdade são os conceitos espinosanos nominalmente invocados por Preciado para pensar Potentia gaudendi ou Força orgásmica, a multidão dos anormais, a servidão e a liberdade na era farmacopornográfica. Desejamos fazer um mapa analítico destes conceitos para entendermos o modo como o pensamento de Espinosa ganha nova luz numa perspectiva queer, que é a de Preciado.
Mito e história: o quebra-cabeça em torno das mulheres e da democracia no Tratado Político de Espinosa
Authors: David Antônio
Published: January 2022

Foco de intensa discussão entre os comentadores de Espinosa, o inacabado capítulo XI do Tratado Político apresenta o que parecem ser as razões da exclusão das mulheres na democracia. Contrapondo-nos a essa leitura, procuramos mostrar a presença do contradiscurso na passagem em questão. Ao cabo, mostramos que o problema em questão permite vislumbrar de que maneira articulam-se as noções de mito e história em Espinosa.
Correspondência entre Espinosa e Oldenburg
Authors: Oliveira Fernando Bonadia de
Published: January 2022

Resenha da tradução Correspondência entre Espinosa e Oldenburg. Tradução, apresentação, estudo, preparação do texto latino e notas: Samuel Thimounier Ferreira. Belo Horizonte: Autêntica. Coleção: Filô: Espinosa (2021).
O Deserto do Sinai
Authors: Hubner Manu Marcus
Published: January 2022

Um lugar fantástico. Inóspito. Seco ao extremo. Cenário de uma das mais extraordinárias narrativas da Bíblia Hebraica: a outorga do Decálogo à humanidade. O deserto do Sinai é um local real, autêntico, por onde passaram os israelitas em suas jornadas em direção à Terra Prometida, assim como o profeta Elias, séculos mais tarde. Este artigo busca estudar o deserto do Sinai através da análise do significado do nome do local, detalhes históricos, geográficos e arqueológicos, além da própria narrativa bíblica.
A divergência entre China e Brasil na questão da imigração: negociações diplomáticas em Paris durante a missão especial à China (1893)
Authors: Wang Jinxu
Published: January 2022

Em março do 1893, uma Missão Especial foi constituída e enviada para China, com intuito de resolver os problemas da escassez de mão-de-obra na economia brasileira, negociando a imigração chinesa ao Brasil. A preparação iniciou-se em fevereiro de 1892, quando Gabriel Piza, então ministro do Brasil em Paris, e Tching Tchang, conselheiro da Legação Chinesa em Paris, negociaram sobre o despacho desta Missão. O Barão de Ladário, o almirante da marinha, José Costa de Azevedo, foi nomeado o representante extraordinário e ministro plenipotenciário da Missão, também realizou encontros de negociação com Tching Tchang durante sua estadia em Paris. O presente artigo aborda os resultados das negociações e seus impactos sobre o projeto brasileiro para a imigração chinesa. Este trabalho basea-se nos arquivos de Tsung-Li Yamên (autoridade que tratou assuntos exteriores no governo chinês da época) e o relatório entregue ao Itamaraty pelo Barão de Ladário.