bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Pelvic-Lumbar-Thigh Biomechanics to Optimize The Childbirth Position: An “In Vivo” Innovative Biomechanical Study
Authors: Desseauve David , Pierre Fabrice , Fernandez Anna , Panjo Henri , Decatoire Arnaud , Lacouture Patrick , Fradet Laetitia
Published: November 2019

The study aimed to assess the associations between the pelvis orientation, lumbar curve and thigh postures throughout pregnancy in a population of healthy women. Additionally, optimal mechanical birth conditions in terms of the pelvic inlet and lumbar curve were researched. The individuals’ posture was assessed with three-dimensional motion analysis and the lumbar curve with the Epionics SPINE system. The association between the hip joint angles (flexion and abduction), the pelvis external conjugate, and lumbar curve position was assessed with a generalized linear mixed model (GLMM) adjusted to individuals’ characteristics. Joint laxity was assessed with a modified Jobbin’s extensometer. For all of the subjects, hip flexion and hip abduction were significantly associated with the angle between the external conjugate and spine, with higher correlation in the multivariate regression model. The association between hip flexion and the lumbar curve was less significant in multivariate than univariate regression analysis. Optimal birth conditions were never reached. The findings contribute to the understanding of the association between the hip position (flexion and abduction), pelvic orientation, and lumbar curve adjusted for joint laxity in healthy pregnant women. They lay the groundwork for future research in the field of obstetrical biomechanics.
A New Strategy for Identifying Mechanisms of Drug-drug Interaction Using Transcriptome Analysis: Compound Kushen Injection as a Proof of Principle
Authors: Shen Hanyuan , Qu Zhipeng , Harata-Lee Yuka , Cui Jian , Aung Thazin Nwe , Wang Wei , Kortschak R. Daniel , Adelson David L.
Published: November 2019

Drug-drug interactions (DDIs), especially with herbal medicines, are complex, making it difficult to identify potential molecular mechanisms and targets. We introduce a workflow to carry out DDI research using transcriptome analysis and interactions of a complex herbal mixture, Compound Kushen Injection (CKI), with cancer chemotherapy drugs, as a proof of principle. Using CKI combined with doxorubicin or 5-Fu on cancer cells as a model, we found that CKI enhanced the cytotoxic effects of doxorubicin on A431 cells while protecting MDA-MB-231 cells treated with 5-Fu. We generated and analysed transcriptome data from cells treated with single treatments or combined treatments and our analysis showed that opposite directions of regulation for pathways related to DNA synthesis and metabolism which appeared to be the main reason for different effects of CKI when used in combination with chemotherapy drugs. We also found that pathways related to organic biosynthetic and metabolic processes might be potential targets for CKI when interacting with doxorubicin and 5-Fu. Through co-expression analysis correlated with phenotype results, we selected the MYD88 gene as a candidate major regulator for validation as a proof of concept for our approach. Inhibition of MYD88 reduced antagonistic cytotoxic effects between CKI and 5-Fu, indicating that MYD88 is an important gene in the DDI mechanism between CKI and chemotherapy drugs. These findings demonstrate that our pipeline is effective for the application of transcriptome analysis to the study of DDIs in order to identify candidate mechanisms and potential targets.
Specific profile of ultrasonic communication in a mouse model of neurodevelopmental disorders
Authors: Premoli Marika , Bonini Sara Anna , Mastinu Andrea , Maccarinelli Giuseppina , Aria Francesca , Paiardi Giulia , Memo Maurizio
Published: November 2019

Mice emit ultrasonic vocalizations (USVs) in different social conditions: pups maternal separation, juveniles play, adults mating and social investigation. The USVs measurement has become an important instrument for behavioural phenotyping in neurodevelopmental disorders (NDDs). Recently, we have demonstrated that the deletion of the NFκB1 gene, which encodes the p50 NF-κB subunit, causes NDDs phenotype in mice. In this study, we investigated the ultrasonic communication and the effects of an early social enrichment in mice lacking the NF-κB p50 subunit (p50 KO). In particular, USVs of wild-type (WT), p50 KO and KO exposed to early social enrichment (KO enriched) were recorded using an ultrasound sensitive microphone and analysed by Avisoft software. USVs analysis showed that p50 KO pups emit more and longer vocalizations compared to WT pups. On the contrary, in adulthood, p50 KO mice emit less USVs than WT mice. We also found significant qualitative differences in p50 KO mice USVs compared to WT mice; the changes specifically involved two USVs categories. Early social enrichment had no effect on USVs number, duration and type in p50 KO mice. Together, these data revealed social communication alterations in a mouse model of NDDs; these deficits were not recovered by early social enrichment, strengthening the fact that genetic background prevails on environmental enrichment.
Study on high temperature solidification behavior and crack sensitivity of Fe-Mn-C-Al TWIP steel
Authors: Zhuang Changling , Liu Jianhua , Li Changrong , Tang Daowen
Published: November 2019

Fe-Mn-C-Al alloy is a new steel grade of TWIP steel developed in recent years. It has an excellent combination of elongation and tensile strength, as well as good anti-delayed fracture property. However, the crack sensitivity of this new TWIP steel has not been reported yet. In this study, differential thermal analysis (DTA) method was used, combined with professional thermodynamic software ThermoCalc to analyze the solidification behavior for Fe-Mn-C-Al alloys with different chemical compositions. Based on this, the crack sensitivity of TWIP steel is further determined. Through this study, it was found that Fe-Mn-C-Al TWIP steel may have a solidification sequence with high crack sensitivity, belonging to hypo-peritectic steel. Moreover, it was found that the carbon content has a large influence on the solidification behavior, and the manganese content also affects the solidification sequence. It can make the phase transition sequence of the solidification process change significantly, which may avoid the solidification behavior of hypo-peritectic reaction. The analysis results by thermodynamic software ThermoCalc are in good agreement with the experimental results. It displays thermoCalc can be a cost-effective way to develop Fe-Mn-C-Al TWIP steel. It is of great significance for shortening the development period of new Fe-Mn-C-Al steel grades.
Environmental and ecological factors mediate taxonomic composition and body size of polyplacophoran assemblages along the Peruvian Province
Authors: Ibáñez Christian M. , Waldisperg Melany , Torres Felipe I. , Carrasco Sergio A. , Sellanes Javier , Pardo-Gandarillas M. Cecilia , Sigwart Julia D.
Published: November 2019

Intertidal communities’ composition and diversity usually exhibit strong changes in relation to environmental gradients at different biogeographical scales. This study represents the first comprehensive diversity and composition description of polyplacophoran assemblages along the Peruvian Province (SE Pacific, 12°S–39°S), as a model system for ecological latitudinal gradients. A total of 4,775 chitons from 21 species were collected on twelve localities along the Peruvian Province. This sampling allowed us to quantitatively estimate the relative abundance of the species in this assemblage, and to test whether chitons conform to elementary predictions of major biogeographic patterns such as a latitudinal diversity gradient. We found that the species composition supported the division of the province into three ecoregional faunal groups (i.e. Humboldtian, Central Chile, and Araucanian). Though chiton diversity did not follow a clear latitudinal gradient, changes in species composition were dominated by smaller scale variability in salinity and temperature. Body size significantly differed by ecoregions and species, indicating latitudinal size-structure assamblages. In some localities body size ratios differed from a random assemblage, evidencing competition at local scale. Changes in composition between ecoregions influence body size structure, and their overlapping produce vertical size segregation, suggesting that competition coupled with environmental conditions structure these assemblages.
Delving into the Antiurolithiatic Potential of Tribulus terrestris Extract Through –In Vivo Efficacy and Preclinical Safety Investigations in Wistar Rats
Authors: Kaushik Jyoti , Tandon Simran , Bhardwaj Rishi , Kaur Tanzeer , Singla Surinder Kumar , Kumar Jitender , Tandon Chanderdeep
Published: November 2019

Modern treatment interventions for kidney stones are wrought with side-effects, hence the need for alternative therapies such as plant-based medicines. We have previously documented through in vitro studies that statistically optimized aqueous extract of Tribulus terrestris (Zygophyllaceae family) possesses antiurolithic and antioxidant potential. This provides strong scientific foundation to conduct in vivo efficacy and preclinical safety studies to corroborate and lend further proof to its ability to prevent and cure kidney stones. The preventive and curative urolithiatic efficacy in experimentally induced nephrolithiatic Wistar rats, along with preclinical toxicity was evaluated following oral administration of statistically optimized aqueous extract of T. terrestris. Treatment showed augmented renal function, restoration of normal renal architecture and increase in body weight. Microscopic analysis of urine revealed excretion of small sized urinary crystals, demonstrating that treatment potentially modulated the morphology of renal stones. Tissue enzymatic estimation affirmed the antioxidant efficacy of treatment with reduced free radical generation. Significant upregulation of p38MAPK at both the gene and protein level was noted in hyperoxaluric group and interestingly treatment reversed it. Acute oral toxicity study established the Median Lethal Dose (LD50) to be greater than 2000 mg/kg body weight (b.wt.) No observed adverse effect level (NOAEL) by repeated oral toxicity for 28 days at 750 mg/kg b.wt. was noted. This study lends scientific evidence to the safe, preventive and curative potential of statistically optimized aqueous extract of T. terrestris at a dose of 750 mg/kg b.wt. and suggests that the extract shows promise as a therapeutic antiurolithic agent.
Shark tooth regeneration reveals common stem cell characters in both human rested lamina and ameloblastoma
Authors: Fraser Gareth J. , Hamed Samar S. , Martin Kyle J. , Hunter Keith D.
Published: November 2019

The human dentition is a typical diphyodont mammalian system with tooth replacement of most positions. However, after dental replacement and sequential molar development, the dental lamina undergoes apoptosis and fragments, leaving scattered epithelial units (dental lamina rests; DLRs). DLRs in adult humans are considered inactive epithelia, thought to possess limited capacity for further regeneration. However, we show that these tissues contain a small proportion of proliferating cells (assessed by both Ki67 and PCNA) but also express a number of common dental stem cell markers (Sox2, Bmi1, β-catenin and PH3) similar to that observed in many vertebrates that actively, and continuously regenerate their dentition. We compared these human tissues with the dental lamina of sharks that regenerate their dentition throughout life, providing evidence that human tissues have the capacity for further and undocumented regeneration. We also assessed cases of human ameloblastoma to characterise further the proliferative signature of dental lamina rests. Ameloblastomas are assumed to derive from aberrant lamina rests that undergo changes, which are not well understood, to form a benign tumour. We suggest that dental lamina rests can offer a potential source of important dental stem cells for future dental regenerative therapy. The combined developmental genetic data from the shark dental lamina and ameloblastoma may lead to the development of novel methods to utilise these rested populations of adult lamina stem cells for controlled tooth replacement in humans.
Comparative gene expression profile analysis of ovules provides insights into Jatropha curcas L. ovule development
Authors: Xu Gang , Huang Jian , Lei Shi-kang , Sun Xue-guang , Li Xue
Published: November 2019

Jatropha curcas, an economically important biofuel feedstock with oil-rich seeds, has attracted considerable attention among researchers in recent years. Nevertheless, valuable information on the yield component of this plant, particularly regarding ovule development, remains scarce. In this study, transcriptome profiles of anther and ovule development were established to investigate the ovule development mechanism of J. curcas. In total, 64,325 unigenes with annotation were obtained, and 1723 differentially expressed genes (DEGs) were identified between different stages. The DEG analysis showed the participation of five transcription factor families (bHLH, WRKY, MYB, NAC and ERF), five hormone signaling pathways (auxin, gibberellic acid (GA), cytokinin, brassinosteroids (BR) and jasmonic acid (JA)), five MADS-box genes (AGAMOUS-2, AGAMOUS-1, AGL1, AGL11, and AGL14), SUP and SLK3 in ovule development. The role of GA and JA in ovule development was evident with increases in flower buds during ovule development: GA was increased approximately twofold, and JA was increased approximately sevenfold. In addition, the expression pattern analysis using qRT-PCR revealed that CRABS CLAW and AGAMOUS-2 were also involved in ovule development. The upregulation of BR signaling genes during ovule development might have been regulated by other phytohormone signaling pathways through crosstalk. This study provides a valuable framework for investigating the regulatory networks of ovule development in J. curcas.
Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions
Authors: Atack John M. , Murphy Timothy F. , Pettigrew Melinda M. , Seib Kate L. , Jennings Michael P.
Published: November 2019

Phasevarions (phase-variable regulons) are emerging as an important area of bacterial gene regulation. Many bacterial pathogens contain phasevarions, with gene expression controlled by the phase-variable expression of DNA methyltransferases via epigenetic mechanisms. Non-typeable Haemophilus influenzae (NTHi) contains the phase-variable methyltransferase modA, of which multiple allelic variants exist (modA1-21). We have previously demonstrated 5 of 21 these modA alleles are overrepresented in NTHi strains isolated from children with middle ear infections. In this study we investigated the modA allele distribution in NTHi strains isolated from patients with chronic obstructive pulmonary disease, COPD. We demonstrate that the distribution of modA alleles in a large panel of COPD isolates is different to the distribution seen in middle ear infections, suggesting different modA alleles may provide distinct advantages in the differing niches of the middle ear and COPD airways. We also identified two new phase-variable modA alleles – modA15 and modA18 – and demonstrate that these alleles methylate distinct DNA sequences and control unique phasevarions. The modA15 and modA18 alleles have only been observed in COPD isolates, indicating that these two alleles may be markers for isolates likely to cause exacerbations of COPD.
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells
Authors: Nakamura Yuki , Sasaki Tomoyuki , Mochizuki Chihiro , Ishimaru Kayoko , Koizumi Schuichi , Shinmori Hideyuki , Suzuki-Inoue Katsue , Nakao Atsuhito
Published: November 2019

Venomous snakebites can induce local tissue damage, including necrosis of soft tissues, haemorrhage, blistering and local swelling associated with plasma extravasation, which can lead to lethal complications such as hypovolemic shock. However, the details of the underlying mechanisms remain unknown. In this study, we showed that intradermal treatment of mice with venom rhodocytin from the Malayan viper Calloselasma rhodostoma induced plasma extravasation, dependent on C-type lectin-like receptor 2 (CLEC-2) on platelets. Rhodocytin-induced plasma extravasation also relied on mast cells and histamine. In vitro co-culture of rhodocytin-activated platelets with mast cells induced histamine release from mast cells in an ATP/P2X7-dependent manner. Consistent with this, blockade or deficiency of P2X7 in mast cells suppressed rhodocytin-induced plasma extravasation in the skin. Together, these findings indicate that rhodocytin induces plasma extravasation by triggering platelet activation via CLEC-2, followed by activation of mast cells and histamine release via the ATP/P2X7 pathway. These results reveal a previously unrecognized mechanism by which snake venom increases vascular permeability via complex venom toxin–mediated interactions between platelets and mast cells.
Exotic magnetic behaviour and evidence of cluster glass and Griffiths like phase in Heusler alloys Fe2-xMnxCrAl (0 ≤ x ≤ 1)
Authors: Yadav Kavita , Sharma Mohit K. , Singh Sanjay , Mukherjee K.
Published: November 2019

We present a detailed study of structural, magnetic and thermodynamic properties of a series of Heusler alloys Fe2-xMnxCrAl (x = 0, 0.25, 0.5, 0.75 and 1). Structural investigation of this series is carried out using high resolution synchrotron X-ray diffraction. Results suggest that with increasing Mn concentration, the L21 structure of Fe2CrAl is destabilized. The DC magnetization results show a decrement in paramagnetic (PM) to ferromagnetic (FM) phase transition temperature (TC) with increasing Mn concentration. From the systematic analysis of magnetic memory effect, heat capacity, time dependent magnetization, and DC field dependent AC susceptibility studies it is observed that, Fe2CrAl exhibits cluster glass(CG)-like transition approximately at 3.9 K (Tf2). The alloys, Fe1.75Mn0.25CrAl and Fe1.5Mn0.5CrAl exhibit double CG-like transitions near Tf1 ~ 22 K, Tf2 ~ 4.2 K and Tf1 ~ 30.4 K, Tf2 ~ 9.5 K respectively, however, in Fe1.25Mn0.75CrAl, a single CG-like transition is noted at Tf2 ~ 11.5 K below TC. Interestingly, FeMnCrAl shows the absence of long ranged magnetic ordering and this alloy undergoes three CG-like transitions at ~22 K (Tf*), 16.6 K (Tf1) and 11 K (Tf2). At high temperatures, a detailed analysis of temperature response of inverse DC susceptibility clearly reveals the observation of Griffiths phase (GP) above 300 K (T*) in Fe2CrAl and this phase persists with Mn concentration with a decrement in T*.
Radiation dose and image quality of high-pitch emergency abdominal CT in obese patients using third-generation dual-source CT (DSCT)
Authors: Forbrig Robert , Ingrisch Michael , Stahl Robert , Winter Katharina Stella , Reiser Maximilian , Trumm Christoph G.
Published: November 2019

In this third-generation dual-source CT (DSCT) study, we retrospectively investigated radiation dose and image quality of portal-venous high-pitch emergency CT in 60 patients (28 female, mean age 56 years) with a body mass index (BMI) ≥ 30 kg/m2. Patients were dichotomized in groups A (median BMI 31.5 kg/m2; n = 33) and B (36.8 kg/m2; n = 27). Volumetric CT dose index (CTDIvol), size-specific dose estimate (SSDE), dose length product (DLP) and effective dose (ED) were assessed. Contrast-to-noise ratio (CNR) and dose-independent figure-of-merit (FOM) CNR were calculated. Subjective image quality was assessed using a five-point scale. Mean values of CTDIvol, SSDE as well as normalized DLP and ED were 7.6 ± 1.8 mGy, 8.0 ± 1.8 mGy, 304 ± 74 mGy * cm and 5.2 ± 1.3 mSv for group A, and 12.6 ± 3.7 mGy, 11.0 ± 2.6 mGy, 521 ± 157 mGy * cm and 8.9 ± 2.7 mSv for group B (p < 0.001). CNR of the liver and spleen as well as each calculated FOM CNR were significantly higher in group A (p < 0.001). Subjective image quality was good in both groups. In conclusion, third-generation abdominal high-pitch emergency DSCT yields good image quality in obese patients. Radiation dose increases in patients with a BMI > 36.8 kg/m2.
Language impairment in adults with end-stage liver disease: application of natural language processing towards patient-generated health records
Authors: Dickerson Lindsay K. , Rouhizadeh Masoud , Korotkaya Yelena , Bowring Mary Grace , Massie Allan B. , McAdams-Demarco Mara A. , Segev Dorry L. , Cannon Alicia , Guerrerio Anthony L. , Chen Po-Hung , Philosophe Benjamin N. , Mogul Douglas B.
Published: November 2019

End-stage liver disease (ESLD) is associated with cognitive impairment ranging from subtle alterations in attention to overt hepatic encephalopathy that resolves after transplant. Natural language processing (NLP) may provide a useful method to assess cognitive status in this population. We identified 81 liver transplant recipients with ESLD (4/2013–2/2018) who sent at least one patient-to-provider electronic message pre-transplant and post-transplant, and matched them 1:1 to “healthy” controls—who had similar disease, but had not been evaluated for liver transplant—by age, gender, race/ethnicity, and liver disease. Messages written by patients pre-transplant and post-transplant and controls was compared across 19 NLP measures using paired Wilcoxon signed-rank tests. While there was no difference overall in word length, patients with Model for End-Stage Liver Disease Score (MELD) ≥ 30 (n = 31) had decreased word length in pre-transplant messages (3.95 [interquartile range (IQR) 3.79, 4.14]) compared to post-transplant (4.13 [3.96, 4.28], p = 0.01) and controls (4.2 [4.0, 4.4], p = 0.01); there was no difference between post-transplant and controls (p = 0.4). Patients with MELD ≥ 30 had fewer 6+ letter words in pre-transplant messages (19.5% [16.4, 25.9] compared to post-transplant (23.4% [20.0, 26.7] p = 0.02) and controls (25.0% [19.2, 29.4]; p = 0.01). Overall, patients had increased sentence length pre-transplant (12.0 [9.8, 13.7]) compared to post-transplant (11.0 [9.2, 13.3]; p = 0.046); the same was seen for MELD ≥ 30 (12.3 [9.8, 13.7] pre-transplant vs. 10.8 [9.6, 13.0] post-transplant; p = 0.050). Application of NLP to patient-generated messages identified language differences—longer sentences with shorter words—that resolved after transplant. NLP may provide opportunities to detect cognitive impairment in ESLD.
Development of disk-shaped monolithic microplates for detecting multiple mycotoxins
Authors: Wang He-Ye , Yang Ya-Li , Wang Yue , Zhang Shuai-Feng , Li Li
Published: November 2019

Organic polymer monoliths have been used extensively for separation and purification of molecules because of their excellent mass transfer properties and versatile surface modification.
Responsive agarose hydrogel incorporated with natural humic acid and MnO2nanoparticles for effective relief of tumor hypoxia and enhanced photo-induced tumor therapy
Authors: Hou Mengmeng , Liu Weiwei , Zhang Lei , Zhang Leiyang , Xu Zhigang , Cao Yang , Kang Yuejun , Xue Peng
Published: November 2019

In spite of widespread applications of nano-photosensitizers, poor tumor penetration and severe hypoxia in the tumor microenvironment (TME) always result in an undesirable therapeutic outcome of photodynamic therapy (PDT).
Spontaneous chiral self-assembly of achiral AIEgens into AIEgen-silica hybrid nanotubes
Authors: Zhang Wanning , Chang Hui , Ai Jing , Che Shunai , Duan Yingying , Han Lu
Published: November 2019

Chiral AIEgen-silica hybrid mesostructures were fabricated by spontaneous chiral self-assembly of achiral amphiphilic AIEgens.
Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling
Authors: Qin Panzhu , Yao Li , Xu Jianguo , Liu Guodong , Chen Wei
Published: November 2019

A target triggered dual-DNA machine composed of RCA and SDA was developed for robust and one-pot determination of miRNA.
Quantum chemical prediction of a superelectrophilic dianion and its binding with noble gas atoms
Authors: Joshi Meenakshi , Ghanty Tapan K
Published: November 2019

A counterintuitive superelectrophilic dianion with a positive charge as well as lowest occupied molecular orbital (LUMO) localized on free-Be1 in Dianion1embedded in the negatively charged framework, forms stable [NgBeB11(CN)11]2−compounds.
A first-principles study on the influences of metal species Al, Zr, Mo and Tc on the mechanical properties of U3Si2
Authors: Gao Haigen , Liu Yande , Hu Jun , Li Xiong
Published: November 2019

A first-principles approach is employed to study the influences of the metal species Al, Zr, Mo and Tc on the mechanical properties of U3Si2.
Assignment of the solid state spectra of the group VI hexacarbonyls by inelastic neutron scattering spectroscopy
Authors: Parker Stewart F. , Jayasooriya Upali A.
Published: November 2019

Inelastic neutron scattering spectroscopy allows all the modes below 800 cm−1of Cr(CO)6, Mo(CO)6and W(CO)6(including the IR and Raman inactive ones) to be observed for the first time.
Exceptional high thermal conductivity of inter-connected annular graphite structures
Authors: Zhuang Shengyi , Zhang Fengying , Liu Yaodong , Lu Chunxiang
Published: November 2019

The inter-connected annular graphite structure designed base on experimentally observed can significantly improve the cross-plane thermal conductivity of graphite.
The curious case of opossum prion: a physicochemical study on copper(ii) binding to the bis-decarepeat fragment from the protein N-terminal domain
Authors: Magrì Antonio , Tabbì Giovanni , Cucci Lorena Maria , Satriano Cristina , Pietropaolo Adriana , Malgieri Gaetano , Isernia Carla , La Mendola Diego
Published: November 2019

The opossum prion tandem repeat peptide binds copper ions differently from the analogous sequence of human prion, inducing different interactions with supported lipid bilayers.
A CsCl-type inorganic cluster-based high-symmetry crystal built from {Mo4.55V7.45PO40}10.45− with a high ratio of vanadium to molybdenum and {(H2O)0.3@K6(H2O)12}6+ clusters exhibiting proton conduction below the freezing point of water
Authors: Yao Zhi-Yuan , Zhang Guo-Qin , Liu Jian-Lan , Zhang Jin , Liu Wen-Long , Ren Xiao-Ming
Published: November 2019

A CsCl-type all inorganic Keggin-type POM network shows proton conduction below the freezing point of water.
Membrane fouling in an integrated adsorption–UF system: effects of NOM and adsorbent properties
Authors: Li Kai , Li Shu , Sun Ce , Huang Tinglin , Li Guibai , Liang Heng
Published: November 2019

In the integrated adsorption–UF process, fouling resistance of the cake layer was influenced by the properties of both feed water NOM and adsorbents.
Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model
Authors: Kozaczek Melisa , Bottje Walter , Greene Elizabeth , Lassiter Kentu , Kong Byungwhi , Dridi Sami , Korourian Soheila , Hakkak Reza
Published: November 2019

Differential expression of genes provides insight into fundamental mechanisms associated with the ability of soy protein isolate to attenuate liver steatosis in genetically obese rats.
Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis
Authors: Qin Xiu-Ying , Wang Ya-Nan , Liu Han-Fu , Luo Zhao-Hui , Zhang Pei-Lu , Li-Fang Huang , Liu Mei-Rong
Published: November 2019

Three novel single crystals of the metal-based complexes Cu-1, Cu-2, and Co-1 were obtained and characterized. Compared with Cu-2 and Co-1, Cu-1 showed remarkable activities of anti-cervical cancer, anti-cisplatin-resistant non-small cell lung cancer and anti-angiogenesis by downregulating the expressions of important proteins in the VEGF/VEGFR2 signaling pathway to inhibit angiogenesis and cancer cell proliferation, induce apoptosis, and suppress migration and metastasis. Moreover, Cu-1 dramatically inhibited the expression of the anti-apoptotic protein Bcl-2 and up-regulated the expressions of the proapoptotic proteins caspase-9 and Bax to induce the apoptosis of tumor cells, simultaneously decreasing the density of endothelial cells to inhibit tumor angiogenesis in cisplatin-resistant tumors.
Polymeric template assisted synthesis of monodisperse-porous manganese oxide microspheres: a new nanozyme with oxidase-like activity allowing biomolecule determination via bimodal sensing
Authors: Babacan Tosun Rukiye , Kip Çiğdem , Tuncel Ali
Published: November 2019

New template assisted synthesis of monodisperse-porous MnO2 microspheres and their usage as a nanozyme in the first bimodal sensing of ascorbic acid.
The synthesis of an antifungal 1,2,4-triazole drug and the establishment of a drug delivery system based on zeolitic imidazolate frameworks
Authors: Jiao Shulin , Li YaoJia , Gao Zhiguo , Chen Ruicheng , Wang Yan , Zou Zhihong
Published: November 2019

Schematic representation of a drug delivery system based on ZIF-8 for the therapy of invasive Candida albicans infections.
Scalable chemical synthesis of doped silicon nanowires for energy applications
Authors: Burchak Olga , Keller Caroline , Lapertot Gérard , Salaün Mathieu , Danet Julien , Chen Yani , Bendiab Nedjma , Pépin-Donat Brigitte , Lombard Christian , Faure-Vincent Jérôme , Vignon Anthony , Aradilla David , Reiss Peter , Chenevier Pascale
Published: November 2019

Growth on a sacrificial salt support provides P-doped Si nanowires as a conductive powder, ready for use in slurry formulation for energy storage electrodes.
Wetting and recovery of nano-patterned surfaces beyond the classical picture
Authors: Marchio Sara , Meloni Simone , Giacomello Alberto , Casciola Carlo Massimo
Published: November 2019

Here we investigate the wetting and dewetting of textured hydrophobic surfaces including inertia effects, which have been neglected in previous studies but are necessary to match experimental results.
Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo
Authors: Li Ke , Lu Lu , Xue Chencheng , Liu Ju , He Ye , Zhou Jun , Xia Zengzilu , Dai Liangliang , Luo Zhong , Mao Yulan , Cai Kaiyong
Published: November 2019

PHNPs and 3-MA re-polarize TAMs to M1-type by activating the protein of NF-κB p65 and then remodelling the immunosuppressive microenvironment, thus activating immune response and inhibiting tumor growth.
Inhibition of light emission from the metastable tetragonal phase at low temperatures in island-like films of lead iodide perovskites
Authors: Chuliá-Jordán Raquel , Fernández-Delgado Natalia , Juárez-Pérez Emilio J. , Mora-Seró Iván , Herrera Miriam , Molina Sergio I. , Martínez-Pastor Juan P.
Published: November 2019

In polycrystalline thin films of MA-PbI3 different tetragonal-defective domains are observed in photoluminescence at low temperatures, whereas the excitonic recombination in the orthorhombic phase is dominating in island-like films.
Surfacing amorphous Ni–B nanoflakes on NiCo2O4 nanospheres as multifunctional bridges for promoting lithium storage behaviors
Authors: Li Min , Zhou Qihao , Ren Changwei , Shen Nan , Chen Qiang , Zhao Jian , Guo Cong , Zhang Lei , Li Jingfa
Published: November 2019

Amorphous Ni–B are introduced onto NiCo2O4 nanospheres to overcome their issues of low conductivity and volume expansion during battery operation.
CoSe2 hollow microspheres, nano-polyhedra and nanorods as pseudocapacitive Mg-storage materials with fast solid-state Mg2+ diffusion kinetics
Authors: Chen Dong , Zhang Yujie , Li Xue , Shen Jingwei , Chen Zhongxue , Cao Shun-an , Li Ting , Xu Fei
Published: November 2019

CoSe2 materials with different nanostructures are used as pseudocapacitive Mg-storage cathodes, which exhibit fast solid-state Mg2+ ions diffusion kinetics.
Electrochemical exfoliation from an industrial ingot: ultrathin metallic bismuth nanosheets for excellent CO2 capture and electrocatalytic conversion
Authors: Wu Dan , Shen Xinquan , Liu Jianwen , Wang Cheng , Liang Yue , Fu Xian-Zhu , Luo Jing-Li
Published: November 2019

Two-dimentional bismuth nanosheets are fabricated on a large-scale by a rapid electrochemical cathodic exfoliation method. These Bi nanosheets exhibit high selectivity toward formic acid in electrocatalytic CO2 reduction.
DNA-based digital comparator systems constructed by multifunctional nanoswitches
Authors: Geng Hongmei , Zhou Chunyang , Guo Chunlei
Published: November 2019

We propose a strategy coupling DNA structural nanoswitches with toehold mediated strand displacement for constructing novel DNA-based digital comparator (DC) logic systems, which as a basic part of traditional electronic computers can compare two or more input numbers.
Facile functionalization of isotactic polypropylene via click chemistry
Authors: Li Yu-Lian , Song Dong-Po , Pan Li , Ma Zhe , Li Yue-Sheng
Published: November 2019

Alkynyl functionalized iPP, with 1–4 mol% comonomer incorporation, can be efficiently synthesized and conveniently converted into various functional iPPs and graft copolymers via alkynyl/N3 reaction.
Anthanthrene-based conjugated polymers for the dispersion of single-walled carbon nanotubes
Authors: Aumaitre Cyril , Fong Darryl , Adronov Alex , Morin Jean-François
Published: November 2019

Four new copolymers based on anthanthrene for the dispersion of semiconducting SWNTs of various diameters have been synthesized.
DFT calculation and analysis of the gas sensing mechanism of methoxy propanol on Ag decorated SnO2 (110) surface
Authors: Li Meihua , Zhu Huichao , Wei Guangfen , He Aixiang , Liu Yanli
Published: November 2019

Methoxy propanol has been widely used in modern industry and consumer products.
Cation exchange synthesis of CuInxGa1−xSe2 nanowires and their implementation in photovoltaic devices
Authors: Jia Guanwei , Wang Kun , Liu Baokun , Yang Peixu , Liu Jinhui , Zhang Weidong , Li Rongbin , Wang Chengduo , Zhang Shaojun , Du Jiang
Published: November 2019

CuInxGa1−xSe2 (CIGS) nanowires were synthesized for the first time through an in situ cation exchange reaction by using CuInSe2 (CIS) nanowires as a template material and Ga-OLA complexes as the Ga source.
Retracted Article: Long noncoding RNA ANRIL protects cardiomyocytes against hypoxia/reoxygenation injury by sponging miR-195-5p and upregulating Bcl-2
Authors: Zhao Hui , Meng Li , Xu Chengyang , Lin Bin , Zheng Xiangming , Wang Jiaxiang , Feng Deguang
Published: November 2019

Long noncoding RNAs have been widely accepted to play important roles in acute myocardial infarction (AMI).
Qualitative and quantitative assessment of genotoxins usingSRRzlysis reporter under the control of a newly designed SOS responsive promoter inEscherichia coli
Authors: Yuan Pengfei , Dong Junqing , Zhao Weibin , Zhuo Min , Li Shuang , Huang Shaobin , Li Jianjun
Published: November 2019

A new bacterial genotoxicity detection strain was constructed, in which the cell lysis gene ofSRRzfrom a lambda phage was controlled by a new designed SOS responsive element, designated asEscherichia coliBL21/pUC-PST.
Dual-response detection of Ni2+ and Cu2+ ions by a pyrazolopyrimidine-based fluorescent sensor and the application of this sensor in bioimaging
Authors: Gu Yun-Qiong , Shen Wen-Ying , Mi Yan , Jing Yan-Fang , Yuan Jing-Mei , Yu Peng , Zhu Xiao-Min , Hu Fei-Long
Published: November 2019

A pyrazolopyrimidine-based fluorescent sensor L was developed and applied for detection of Cu2+ and Ni2+ in ethanol solution by photoluminescence quenching. It shows low cytotoxicity and good imaging characteristics for Cu2+ and Ni2+ in living cells.
Heterogeneous photocatalytic performances of CO2 reduction based on the [Emim]BF4 + TEOA + H2O system
Authors: Lin Jinliang , Li Youfeng , Xie Bo
Published: November 2019

The photochemical reduction of CO2 was studied in a 1-ethyl-3-methylimidazolium tetrafluoroborate, triethanolamine and water ([Emim]BF4 + TEOA + H2O) system under visible light irradiation.
Polymorphism in carbohydrate self-assembly at surfaces: STM imaging and theoretical modelling of trehalose on Cu(100)
Authors: Abb Sabine , Tarrat Nathalie , Cortés Juan , Andriyevsky Bohdan , Harnau Ludger , Schön J. Christian , Rauschenbach Stephan , Kern Klaus
Published: November 2019

We rationalize the experimentally observed variety of trehalose assemblies on Cu(100) by modeling based on STM images and global optimization.
Effects and formulation of silver nanoscaffolds on cytotoxicity dependent ion release kinetics towards enhanced excision wound healing patterns in Wistar albino rats
Authors: Sethuram Lakshimipriya , Thomas John , Mukherjee Amitava , Chandrasekaran Natarajan
Published: November 2019

A sustained and controlled release of silver ions from AgNPs is driven by greater percentage of wound contraction with minimal cytotoxic behavioural rates and effective antibacterial activity.
Acetone fractionation: a simple and efficient method to improve the performance of lignin for dye pollutant removal
Authors: Li Hao , Yuan Ze , Xing Yuyu , Li Jiarong , Fang Jing , Chang Lifang , Li Chunli
Published: November 2019

In this work, it was found that the adsorption capacity of lignin to cationic dye (methylene blue, MB) from aqueous solution could be significantly improved by simple acetone fractionation.
Reducing uncertainty in simulation estimates of the surface tension through a two-scale finite-size analysis: thicker is better
Authors: Rivera José L. , Douglas Jack F.
Published: November 2019

The variance in the surface tension of systems under vapor/liquid equilibrium is strongly affected by the size of the interfacial area. Wider layers increase the variance, but these increments disappear as the interfacial area grows.
Aggregation-induced emission enhancement (AIEE)-active boron-difluoride dyes with reversible mechanochromic fluorescence
Authors: Yan Xiaojing , Zhu Pengcheng , Zhou Zhiguo , Yang Hong , Lan Haichuang , Xiao Shuzhang
Published: November 2019

A class of AIEE-active mechanochromic boron-difluorides were reported, and the mechanochromism was ascribed to the transition between H(J)-aggregation with loose molecular packing and J-aggregation with intense intermolecular interactions.
t-BuOK-catalysed alkylation of fluorene with alcohols: a highly green route to 9-monoalkylfluorene derivatives
Authors: Fan Jiang-Tao , Fan Xin-Heng , Gao Cai-Yan , Wang Zhenpeng , Yang Lian-Ming
Published: November 2019

9-Monoalkylated fluorene derivatives were synthesized from 9-fluorene and alcohols in the presence of t-BuOK as catalyst under mild conditions.
Quasiparticle effects on the linear and nonlinear susceptibility of ZnGeP2
Authors: Xie Hua , Fang Shenghao , Zhao He , Xu Xiaoliang , Ye Ning , Zhuang Wei
Published: November 2019

The semiconductor zinc germanium diphosphide (ZnGeP2) has wide applications in the infrared nonlinear optics (NLO) due to its high nonlinear optical coefficient, wide infrared transparency range and high thermal conductivity.
Extraction and transport of sulfate using macrocyclic squaramide receptors
Authors: Qin Lei , Vervuurt Sacha J. N. , Elmes Robert B. P. , Berry Stuart N. , Proschogo Nicholas , Jolliffe Katrina A.
Published: November 2019

Lipophilic macrocycles efficiently extract sulfate ions from water into chloroform and transport this ion across a bulk liquid membrane in the presence of competing anions (chloride, nitrate and dihydrogenphosphate).
Significantly improved electrocatalytic oxygen reduction by an asymmetrical Pacman dinuclear cobalt(ii) porphyrin–porphyrin dyad
Authors: Liu Yanju , Zhou Guojun , Zhang Zongyao , Lei Haitao , Yao Zhen , Li Jianfeng , Lin Jun , Cao Rui
Published: November 2019

Asymmetrical Pacman dinuclear Co bisporphyrin shows significantly improved activity and selectivity for catalytic reduction of O2 to water in comparison with corresponding mononuclear Co porphyrins and symmetrical dinuclear Co bisporphyrins.
Selective hydrogenation of furfural to tetrahydrofurfuryl alcohol over a Rh-loaded carbon catalyst in aqueous solution under mild conditions
Authors: Matsagar Babasaheb M. , Hsu Chang-Yen , Chen Season S. , Ahamad Tansir , Alshehri Saad M. , Tsang Daniel C. W. , Wu Kevin C.-W.
Published: November 2019

We describe the selective hydrogenation of furfural (FAL) into tetrahydrofurfuryl alcohol (THFA) under mild conditions (30 °C) in aqueous media using a Rh-loaded carbon (Rh/C) catalyst in a one-pot fashion.
Minimising the levelised cost of electricity for bifacial solar panel arrays using Bayesian optimisation
Authors: Tillmann Peter , Jäger Klaus , Becker Christiane
Published: November 2019

Bayesian optimisation yields up to 23% lower levelised cost of electricity of bifacial solar farms.
Three-terminal III–V/Si tandem solar cells enabled by a transparent conductive adhesive
Authors: Schnabel Manuel , Schulte-Huxel Henning , Rienäcker Michael , Warren Emily L. , Ndione Paul F. , Nemeth Bill , Klein Talysa R. , van Hest Maikel F. A. M. , Geisz John F. , Peibst Robby , Stradins Paul , Tamboli Adele C.
Published: November 2019

Three-terminal tandem solar cell with conductive adhesive interconnect and back-contacted bottom cell delivers 27.3% efficiency.
Surface passivation via acid vapor etching enables efficient and stable solution-processed CdTe nanocrystal solar cells
Authors: Guo Xiuzhen , Rong Zhitao , Wang Le , Liu Songwei , Liu Zhe , Luo Kaiying , Chen Bingchang , Qin Donghuan , Ma Yuguang , Wu Hongbin , Hou Lintao
Published: November 2019

Achieving stable and low-resistance interfaces for hole transport layers with well-matched energy levels is crucial to maximize the performance of solution-processed CdTe nanocrystal (NC) based solar cells.
The effect of blob size in polymer networks on nanoparticle-mediated adhesion of hydrogels
Authors: Kim Sohyun , Kang Tae Hui , Yi Gi-Ra
Published: November 2019

Mesoporous silica nanoparticles can be used as an adhesive for hydrogels due to their physical adsorption to polymer chains, in which adhesion energy can be affected by the ratio of mesh size and pore diameter.
Interaction of phospholipid vesicles with gemini surfactants of different lysine spacer lengths
Authors: Zhang Na , Qi Ruilian , Li Haofei , Guan Bo , Liu Yang , Han Yuchun , Wang Yilin
Published: November 2019

Cationic peptide gemini surfactants based on lysine spacers exhibit potent antibacterial activity. This work is aimed at understanding the peptide surfactant/phospholipid interaction.
Carrot-inspired solar thermal evaporator
Authors: Long Yaojia , Huang Shaolong , Yi Huan , Chen Jiaqi , Wu Jiahao , Liao Qiufan , Liang Huawei , Cui Hongzhi , Ruan Shuangchen , Zeng Yu-Jia
Published: November 2019

A carrot-inspired solar thermal evaporator exhibits a water evaporation rate of 2.04 kg m−2 h−1 and an outstanding durability and stability.
Boosting electrocatalytic oxygen evolution over Prussian blue analog/transition metal dichalcogenide nanoboxes by photo-induced electron transfer
Authors: Xu Hui , Shang Hongyuan , Jin Liujun , Chen Chunyan , Wang Cheng , Du Yukou
Published: November 2019

Construction of well-designed CoFe PBA/CoS2 nanoboxes with excellent photoelectrocatalytic performance for the oxygen evolution reaction is presented.
FeP3 monolayer as a high-efficiency catalyst for hydrogen evolution reaction
Authors: Zheng Shuang , Yu Tong , Lin Jianyan , Lou Huan , Xu Haiyang , Yang Guochun
Published: November 2019

An urgent and key problem in hydrogen evolution reaction (HER) is to prepare low-cost catalysts with activity comparable to that of platinum (Pt), an intrinsic large number of active sites, and high electrical conductivity.
Natural skin-inspired versatile cellulose biomimetic hydrogels
Authors: Lin Fengcai , Wang Zi , Shen Yanping , Tang Lirong , Zhang Pinle , Wang Yuefang , Chen Yandan , Huang Biao , Lu Beili
Published: November 2019

A skin-like cellulose biomimetic hydrogel was prepared based on dynamic covalent chemistry, which realized the combination of ultra-stretchability, self-healing, adhesiveness, antibacterial and mechano-stimuli sensitivity within a single structure.
Functionalized calcium orthophosphates (CaPO4) and their biomedical applications
Authors: Dorozhkin Sergey V.
Published: November 2019

Due to the chemical similarity to natural calcified tissues (bones and teeth) of mammals, calcium orthophosphates (abbreviated as CaPO4) appear to be good biomaterials for creation of artificial bone grafts.
g-C3N4 nanosheet-based ratiometric fluorescent probes for the amplification and imaging of miRNA in living cells
Authors: Wang Yiting , Wu Na , Guo Fengna , Gao Ruixue , Yang Ting , Wang Jianhua
Published: November 2019

By using BCNNS as a nanocarrier, a fluorescence quencher and an interior label, and using CuNC-labeled hairpin DNA for dual-signal output, a dual-emission ratiometric fluorescent probe was fabricated for the measurement of intracellular miRNA.
Ultrafast, sensitive and visual sensing of copper ions by a dual-fluorescent film based on quantum dots
Authors: Han Ting , Yuan Ye , Kang Hong , Zhang Yang , Dong Lijie
Published: November 2019

We have developed a dual-fluorescent film sensor for the ultrafast, sensitive and visual detection of Cu2+ with remarkable portability and environmental stability.
Robust, multiscale liquid-metal patterning enabled by a sacrificial sealing layer for flexible and wearable wireless powering
Authors: Teng Long , Zhu Lifei , Handschuh-Wang Stephan , Zhou Xuechang
Published: November 2019

A robust patterning method was developed for the fabrication of liquid metal patterns toward flexible and wearable wireless powering.
Photons and charges from colloidal doped semiconductor quantum dots
Authors: Qiao Tian , Parobek David , Son Dong Hee
Published: November 2019

This work discusses the photophysical pathways in doped quantum dots responsible for generating photons of non-exciton origin and hot electrons.
Flexible PVDF/carbon materials/Ni composite films maintaining strong electromagnetic wave shielding under cyclic microwave irradiation
Authors: Zhao Biao , Zeng Shuiping , Li Xiping , Guo Xiaoqin , Bai Zhongyi , Fan Bingbing , Zhang Rui
Published: November 2019

In current work, multiwalled carbon nanotubes (MWCNTs), graphene nanoplatelets (GnPs) and nickel (Ni chains or flowers) were evenly dispersed in poly(vinylidene fluoride) (PVDF) matrices to fabricate composite flexible films.
The association between IL-17 gene variants and risk of colorectal cancer in a Chinese population: A case–control study
Authors: Feng Haiyang , Ying Rongbiao , Chai Tengjiao , Chen Hailang , Ju Haixing
Published: November 2019

Interleukin (IL)-17 have been reported to be associated with the pathogenesis of colorectal cancer (CRC). Few studies investigated the association between IL-17 gene polymorphisms and risk of CRC with inconsistent findings. Thus, we recruited 352 CRC cases and 433 controls in a Chinese population and their genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. Our data showed that IL-17A rs2275913 polymorphism was associated with the increased risk of CRC, while no association was observed for IL-17F rs763780 polymorphism. Stratified analyses revealed that the significant association was also obtained in the females, smokers, drinkers and age ≥ 60 years groups for rs2275913 polymorphism. Moreover, the CC and/or GC genotype of rs2275913 polymorphism were correlated with TNM stage and lymph node metastasis. No association was shown between IL-17F rs763780 polymorphism and clinical characteristics of CRC. In conclusion, our data indicate that IL-17A rs2275913 polymorphism but not IL-17F rs763780 polymorphism contributes to increased risk for CRC patients in this Chinese population.