bluuebunny/crossref_metadata_2025 huggingface dataset:
Complete Genome Sequence of
Lactiplantibacillus plantarum
VHProbi O10, Isolated from Kimchi
Authors: Cui Hongchang , Wang Jun , Duan Zhi
Published: October 2022

Lactiplantibacillus plantarum
strain VHProbi O10 is our proprietary probiotic that was isolated from kimchi soup. Here, we investigated the whole-genome sequence of this strain, which contains a chromosome and a plasmid.
High-Quality Genome Sequences of Six Actinobacterial Strains Isolated from Granite, Granodiorite, and Tourmaline Rock Surfaces Sampled from Tamil Nadu, India, and New England, United States
Authors: Gueddou Abdellatif , Ennis Nathaniel J. , Dharumadurai Dhanasekaran , Tisa Louis S.
Published: October 2022

Here, we announce four contiguous and two high-quality draft genome sequences of six actinobacterial strains (
Blastococcus, Georgenia, Nocardioides, Allobranchiibius, Yimella,
and
Williamsia
) that were isolated from rock samples obtained from Indian historical ruins and colonial building stones in New England, United States. These new sequences expand the genome datasets recovered from stone-dwelling microbes and will allow the prediction of their potential role in the stone microbiome.
Potential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Authors: Fang Zuye , Lai Fubin , Cao Kun , Zhang Ziyuan , Cao Linlin , Liu Shiqin , Duan Yufeng , Yin Xingfeng , Ge Ruiguang , He Qing-Yu , Sun Xuesong
Published: October 2022

The misuse of antibiotics has resulted in the emergence of many antibiotic-resistant strains which seriously threaten human health. Protein post-translational modifications, especially acetylation, tightly control bacterial metabolism.
Clinical Biochemical Indicators and Intestinal Microbiota Testing Reveal the Influence of Reproductive Age Extending from the Mother to the Offspring
Authors: Li Xiaoqing , Zhang Bing , Zheng Jiayong , Chen Haiying , Zheng Jianqiong , Xu Xiaomin , Wang Wenhuan , Sun Congcong , Lin Wenjing , Chen Kaixin , Xu Zitong , Zhang Hongping , Wang Jinfeng
Published: October 2022

In this study, we demonstrated that physiological indicators and the gut microbiome fluctuate drastically among parturients of different reproductive ages and that there is a significant correlation between the two changes. Mothers of different ages had different gut microbes, and the gut microbiota varied as the childbearing age became too high.
Thermal Endurance by a Hot-Spring-Dwelling Phylogenetic Relative of the Mesophilic
Paracoccus
Authors: Mondal Nibendu , Roy Chayan , Chatterjee Sumit , Sarkar Jagannath , Dutta Subhajit , Bhattacharya Sabyasachi , Chakraborty Ranadhir , Ghosh Wriddhiman
Published: October 2022

For a holistic understanding of microbial life’s high-temperature adaptation, it is imperative to explore the biology of the phylogenetic relatives of mesophilic bacteria which get stochastically introduced to geographically and geologically diverse hot spring systems by local geodynamic forces. Here,
in vitro
endurance of high heat up to the extent of growth under special (habitat-inspired) conditions was discovered in a hot-spring-dwelling phylogenetic relative of the mesophilic
Paracoccus
species. Thermal conditioning, extreme oligotrophy, metabolic deceleration, presence of certain habitat-specific inorganic/organic solutes, and potential genomic specializations were found to be the major enablers of this conditional (acquired) thermophilicity.
The Threat of Potentially Pathogenic Bacteria in the Feces of Bats
Authors: Huang Yuyuan , Sun Yamin , Huang Qianni , Lv Xianglian , Pu Ji , Zhu Wentao , Lu Shan , Jin Dong , Liu Liyun , Shi Zhengli , Yang Jing , Xu Jianguo
Published: October 2022

Bats are one of the most diverse and widely distributed groups of mammals living in close proximity to humans. In recent years, bat-borne viruses and the viral zoonotic diseases associated with bats have been studied in great detail.
SNARE Protein DdVam7 of the Nematode-Trapping Fungus
Drechslerella dactyloides
Regulates Vegetative Growth, Conidiation, and the Predatory Process via Vacuole Assembly
Authors: Chen Yue , Liu Jia , Fan Yani , Xiang Meichun , Kang Seogchan , Wei Dongsheng , Liu Xingzhong
Published: October 2022

D. dactyloides
is a nematode-trapping fungus that can capture nematodes through a constricting ring, the most sophisticated trapping device. It is amazing that constricting ring cells can inflate to triple their size within seconds to capture a nematode.
Unraveling Capsule Biosynthesis and Signaling Networks in Cryptococcus neoformans
Authors: Jang Eun-Ha , Kim Ji-Seok , Yu Seong-Ryong , Bahn Yong-Sun
Published: October 2022

Over the past decades, human fungal pathogens, including
C. neoformans
, have emerged as a major public threat since the AIDS pandemic, only to gain more traction in connection to COVID-19. Polysaccharide capsules are rare fungal virulence factors that are critical for protecting
C. neoformans
from phagocytosis by macrophages.
Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication
Authors: Cushion Melanie T. , Ashbaugh Alan , Sayson Steven G. , Mosley Christopher , Hauser Philippe M.
Published: October 2022

The concept of a sexually obligate fungus is unique among human fungal pathogens. This reliance can be exploited for drug development and here we show a proof of principle for this unusual target.
Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota
Authors: Li Xueying , Xu Shuang , Zhang Yanhe , Li Kan , Gao Xue-Jiao , Guo Meng-yao
Published: October 2022

Ulcerative colitis (UC) is common in clinics. Intestinal microbiota disorder is correlated with ulcerative colitis.
Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma
Authors: Stewart Kirsten E , Zeidler Martin , Srinivasan Devraj , Yeo Justin C L
Published: October 2022

Nasopharyngeal carcinoma can present with epistaxis, cervical lymphadenopathy, audiological symptoms secondary to eustachian tube dysfunction, pain, or neurological symptoms from tumours directly invading the skull base. It is unusual for patients to present with indirect systemic manifestations. Paraneoplastic neurological syndrome can precede clinically overt malignancy by up to 5 years; therefore, a combination of thorough clinical, laboratory and radiological investigations is required to reach a diagnosis. Intravenous immunoglobulin and steroids might improve neurological symptoms initially and prevent irreversible neuronal damage, but treatment of the underlying cancer is important for long-term resolution. Our case adds to a small but growing body of literature related to anti-Ri antibodies, opsoclonus-myoclonus syndrome presentations, and is the first reported association of this combination with nasopharyngeal carcinoma.
Pupillotonia after endolaser retinopexy during vitrectomy for retinal detachment: a prospective cohort study comparing circumferential and focal retinopexy
Authors: Skevas Christos , Thiwa David , Bartz-Schmidt Karl-Ulrich , Katz Toam , Spitzer Martin , Dimopoulos Spyridon
Published: October 2022

Purpose

To determine differences in postoperative pupil diameter in eyes that undergo pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) with endolaser retinopexy (ELR), comparing 360° vs focal ELR.

Methods

Patients with uncomplicated RRD who underwent PPV were prospectively analysed regarding the postoperative pupil diameter difference (PDD) between the affected eye and the partner eye. Group 1 underwent 360° ELR and group 2 received focal ELR. Postoperative vision and complications, including redetachment rate, macular oedema and epiretinal membrane formation, were also compared.

Results

A total of 72 patients, 42 in group 1 and 30 in group 2, were analysed. PDD, as observed at 6 weeks, was significantly greater than the preoperative values in both groups 1 and 2. It increased by a mean of 1±1.11 mm in group 1 and by 0.5±0.78 in group 2. This initial increase in PDD receded over time, but remained statistically significant in both groups, even at 6 months. The top 20% of patients with the largest PDD change comprised 13 out of 15 eyes from group 1, which was a statistically significant overrepresentation (p=0.0435).

Conclusions

Moderate pupillotonia was induced post-ELR in vitrectomy and correlated to the extent of ELR. The pupillotonia effect of ELR was significantly less marked in pseudophakic eyes.
Food insecurity, diet quality, and suboptimal diabetes management among US adults with diabetes
Authors: Casagrande Sarah S , Bullard Kai McKeever , Siegel Karen R , Lawrence Jean M
Published: October 2022

Introduction

A healthy diet is recommended to support diabetes management, including HbA1c, blood pressure, and cholesterol (ABC) control, but food insecurity is a barrier to consuming a healthy diet. We determined the prevalence of food insecurity and diet quality among US adults with diabetes and the associations with ABC management.

Research design and methods

Cross-sectional analyses were conducted among 2075 adults ≥20 years with diagnosed diabetes who participated in the 2013–2018 National Health and Nutrition Examination Surveys. Food insecurity was assessed using a standard questionnaire and diet quality was assessed using quartiles of the 2015 Healthy Eating Index. Adjusted ORs (aOR, 95% CI) were calculated from logistic regression models to determine the association between household food insecurity/diet quality and the ABCs while controlling for sociodemographic characteristics, healthcare utilization, smoking, medication for diabetes, blood pressure, or cholesterol, and body mass index.

Results

Overall, 17.6% of adults had food insecurity/low diet quality; 14.2% had food insecurity/high diet quality; 33.1% had food security/low diet quality; and 35.2% had food security/high diet quality. Compared with adults with food security/high diet quality, those with food insecurity/low diet quality were significantly more likely to have HbA1c ≥7.0% (aOR=1.85, 95% CI 1.23 to 2.80) and HbA1c ≥8.0% (aOR=1.79, 95% CI 1.04 to 3.08); food insecurity/high diet quality was significantly associated with elevated HbA1c; and food security/low diet quality with elevated A1c.

Conclusions

Food insecurity, regardless of diet quality, was significantly associated with elevated A1c. For people with food insecurity, providing resources to reduce food insecurity could strengthen the overall approach to optimal diabetes management.
SAFER framework for moving forward on the medical device right to repair
Authors: He Shuhan , Lai Debbie , Jin Grace , Lee Jarone
Published: October 2022

Across various industries, the right to repair (RTR) movement has gained momentum as more than 20 states have proposed RTR laws to expand access to repair of consumer products. Medical device equipment shortages during the COVID-19 pandemic demonstrated that stronger repair mechanisms are necessary for the US health system to become more efficient, affordable and sustainable. We propose a 5-point SAFER framework including safety and security, adaptability, fiscal, environmental and regulatory factors for consideration in implementing medical device RTR. The healthcare community can help advance RTR legislation in a manner that serves our patients and healthcare system best.
Prognostic risk factor analysis and nomogram construction for primary liver cancer in elderly patients based on SEER database
Authors: Li Fangyuan , Zheng Ting , Gu Xuewei
Published: October 2022

Objective

To evaluate the risk factors and construct a nomogram model for the prognosis of primary liver cancer in the elderly based on the data from the US SEER database.

Methods

The latest data of patients with primary liver cancer were extracted from the SEER database using SEER*STAT software, and the required variables were included. The data were screened and then divided into a training cohort and a validation cohort. A nomogram model was constructed by screening the variables through univariate and multivariate Cox analysis. The C-Index, ROC and calibration curves were used for model evaluation.

Results

A total of 10 824 eligible cases from 2004 to 2017 were extracted, among which, 7757 cases were included in the training cohort and 3247 in the validation cohort. The C-Index of the model was 0.747 (in the training cohort) and 0.773 (in the validation cohort). The 3-year area under the curve (AUCs) of the training and the validation cohorts were 0.760 and 0.750, and the 5-year AUCs of the two cohorts were 0.761 and 0.748. The calibration curves showed an ideal calibration of the constructed model.

Conclusions

The nomogram model constructed followed by Cox regression analysis showed moderate calibration and discrimination property, and can provide reference to a certain extent for furture clinical application of primary liver cancer in the elderly.
Fetal–neonatal and maternal pregnancy outcomes in women with rheumatoid arthritis: a population-based cohort study
Authors: Tsai Yun-Chen , Chang Hsiao-Chun , Chiou Meng-Jiun , Luo Shue-Fen , Kuo Chang-Fu
Published: October 2022

Objectives

Rheumatoid arthritis (RA) may adversely influence pregnancy and lead to adverse birth outcomes. This study estimated the risk of adverse fetal–neonatal and maternal pregnancy outcomes in women with RA.

Design

This was a retrospective cohort study.

Setting

We used both the National Health Insurance database and the Taiwan Birth Reporting System, between 2004 and 2014.

Participants

We identified 2 100 143 singleton pregnancies with 922 RA pregnancies, either live births or stillbirths, delivered by 1 468 318 women.

Outcome measures

ORs with 95% CIs for fetal–neonatal and maternal outcomes were compared between pregnancies involving mothers with and without RA using an adjusted generalised estimating equation model.

Results

Covariates including age, infant sex, Charlson Comorbidity Index, urbanisation, income, occupation, birth year and maternal nationality were adjusted. Compared with pregnancies in women without RA, pregnancies in women with RA showed that the fetuses/neonates had adjusted ORs (95% CI) of 2.03 (1.66 to 2.50) for low birth weight (n=123), 1.99 (1.64 to 2.40) for prematurity (n=141), 1.77 (1.46 to 2.15) for small for gestational age (n=144) and 1.35 (1.03 to 1.78) for fetal distress (n=60). Pregnancies in women with RA had adjusted ORs (95% CI) of 1.24 (1.00 to 1.52) for antepartum haemorrhage (n=106), 1.32 (1.15 to 1.51) for caesarean delivery (n=398), and 3.33 (1.07 to 10.34) for disseminated intravascular coagulation (n=3), compared with women without RA. Fetuses/neonates born to mothers with RA did not have a higher risk of being stillborn or having fetal abnormalities. Pregnant women with RA did not have increased risks of postpartum death, cardiovascular complications, surgical complications or systemic organ dysfunction.

Conclusions

Pregnancies in women with RA were associated with higher risks of multiple adverse fetal–neonatal and maternal outcomes; however, most pregnancies in these women were successful.
Comparison between collateral status and DEFUSE 3 or DAWN criteria in patient selection for endovascular thrombectomy within 6−24 hours after stroke: a protocol for meta-analysis
Authors: Shen Yuling , Li Mao , Chen Yun , Liu Shanyu , Liu Junyan , Yang Dongdong
Published: October 2022

Introduction

Perfusion imaging according to the DEFUSE 3 or DAWN criteria has been applied to select patients with large vascular occlusive stroke undergo endovascular therapy (EVT) in the extended time window. Emerging studies have shown that collateral blood flow-based criteria may be as effective as DEFUSE 3 and DAWN criteria for the evaluation of EVT eligibility beyond 6 hours. We will conduct a meta-analysis to compare collateral status-based criteria with DEFUSE 3 or DAWN criteria.

Methods and analysis

We will conduct a search for the studies comparing collateral blood flow-based imaging with CT perfusion using the DEFUSE 3 or DAWN criteria in selecting patients with acute ischaemic stroke undergo EVT in the Web of Science, PubMed, EMBASE and the Cochrane Library databases between November 2017 and November 2021. We will also search the sources of grey literature, the reference lists of included studies and the newly published studies during the review period. Two investigators will independently screen the eligible studies and extract data. The study quality will be assessed by using the Newcastle-Ottawa Scale or the Cochrane risk bias tool. Stata V.17 will be used to conduct data analysis.

Ethics and dissemination

Patient informed consent and ethics approval are not necessary as this study uses only published studies. The finding of this meta-analysis will be propagated through committee conferences or peer-reviewed journals.

PROSPERO registration number

CRD42021281928.
What is the gender representation in authorship in later phase systemic clinical trials in biliary tract cancer (BTC)? - a retrospective review of the published literature
Authors: McNamara Mairéad G , Bridgewater John , Goyal Lipika , Jacobs Timothy , Wagner Anna D , Goldstein David , Shroff Rachna , Moehler Markus , Lowery Maeve , Bekaii-Saab Tanios , Kelley Robin K , Furuse Junji , Rimassa Lorenza , Morizane Chigusa , Lamarca Angela , Hubner Richard , Knox Jennifer , Valle Juan
Published: October 2022

Objectives

Female physicians in medicine are increasing, but disparities in female authorship exist. The aim of this study was to characterise factors associated with female first (FF) and female senior (SF) authorship in later phase systemic oncological clinical trials in biliary tract cancer (BTC) and identify any changes over time.

Setting

Embase/Medline identified trial publications in BTC (2000–2020) were included. χ2tests and log regression were used (assessed factors associated with FF and SF authorship, including changes over time (STATA V.16)).

Primary outcome measure

FF and SF authorship in later phase systemic oncological clinical trials in BTC.

Secondary outcome measure

Any changes over time?

Results

Of 501 publications, 163 met inclusion criteria. The median percentage of female author representation in publications was 25%; there were no female authors in 13% of publications. Geographic location of the home institution of the first and senior authors was Asia (42%/42%), Europe (29%/29%), USA (24%/22%) and other (4%/6%), respectively. Overall, FF and SF author representation was 20% and 10%, respectively. The median position of the first female author was second in all the publication author lists. The phase of trial, journal-impact factor, industry funding or whether the study met its primary endpoint did not impact FF/SF author representation. More SF authors had home institutions in ‘other’ geographic locations (40% in 10 trials) (p=0.02) versus Asia (6%), Europe (8%) and USA (14%). There were no significant changes in FF/SF representation over time (p=0.61 and p=0.33 respectively).

Conclusions

FF and SF author representation in later phase systemic clinical trial publications in BTC is low and has not changed significantly over time. The underlying reasons for this imbalance need to be better understood and addressed.
Patient safety culture and associated factors in secondary health care of the Capital Region of Denmark: influence of specialty, healthcare profession and gender
Authors: Østergaard Doris , Madsen Marlene Dyrløv , Ersbøll Annette Kjær , Frappart Helle Søgaard , Kure Josefine Haahr , Kristensen Solvejg
Published: October 2022

Background

We aimed to explore (1) the influence of healthcare professionals' (HCPs’) specialty, profession, gender and length of employment on their perception of six dimensions of patient safety culture (PSC) and (2) the relation between these characteristics and the two dimensions of safety climate and perception of management.

Methods

In a cross-sectional study, a Danish version of the Safety Attitudes Questionnaire was sent to all HCPs at a large regional hospital organisation. This included hospitals, the Emergency Services, the Regional Pharmacy and the Centre for Diabetes corporations. A total of 30 230 HCPs received the survey. Differences between specialties, professions, gender and years of employment were tested for each dimension of PSC. Differences in mean attitude scores were tested using analysis of variance and differences in having a positive attitude were tested using logistic regression.

Results

In total, 15 119 (50%) HCPs returned the survey. Significant differences are seen across hospitals and corporations for all dimensions of PSC. The proportion of HCPs with a positive attitude was largest regarding job satisfaction (74.8%) and lowest regarding perception of management (43.9%). Significant differences are seen in physicians' and nurses' perception of PSC in the different specialties within all dimensions of PSC except for the dimension of recognition of stress. Significant differences in positive perception of teamwork climate are seen between anaesthesiologists' (69.4%) and surgeons' (41.7%). No significant gender differences were found between physicians' and nurses' perception of safety climate and of management. In addition, we found an influence of years of employment on PSC.

Discussion

Significant differences were found in HCPs' perception of PSC between corporations, specialties and professions. The lowest proportion of HCPs with a positive perception of PSC was found within the dimensions of safety climate and perception of management. These differences may have implications for teamwork and patient safety.
Prospective RandOmised Trial of Emergency Cardiac Computerised Tomography (PROTECCT)
Authors: Aziz Waqar , Morgan Holly , Demir Ozan M , Sinha Aish , Rua Tiago , Rajani Ronak , Chang Ai-Lee , Woo Eric , Mak Sze Mun , Benedetti Giulia , Villa Adriana , Preston Rebecca , Navin Roshan , O'Kane Kevin , Hunter Laura , Ismail Tevfik , Carr-White Gerry , Beckley-Hoelscher Nick , Peacock Janet , Marber Michael , Razavi Reza , Perera Divaka
Published: October 2022

Objective

Many patients presenting with suspected acute coronary syndrome (ACS) have high-sensitivity cardiac troponin (hs-cTn) concentrations between rule-in and rule-out thresholds and hence need serial testing, which is time consuming. The Prospective RandOmised Trial of Emergency Cardiac Computerised Tomography (PROTECCT) assessed the utility of coronary CT angiography (CCTA) in patients with suspected ACS, non-ischaemic ECG and intermediate initial hs-cTn concentration.

Methods

Patients were randomised to CCTA-guided management versus standard of care (SOC). The primary outcome was hospital length of stay (LOS). Secondary outcomes included cost of in-hospital stay and major adverse cardiac events (MACE) at 12 months of follow-up. Data are mean (SD); for LOS harmonic means, IQRs are shown.

Results

250 (aged 55 (14) years, 25% women) patients were randomised. Harmonic mean (IQR) LOS was 7.53 (6.0–9.6) hours in the CCTA arm and 8.14 (6.3–9.8) hours in the SOC arm (p=0.13). Inpatient cost was £1285 (£2216) and £1108 (£3573), respectively, p=0.68. LOS was shorter in the CCTA group in patients with <25% stenosis, compared with SOC; 6.6 (5.6–7.8) hours vs 7.5 (6.1–9.4) hours, respectively; p=0.021. More referrals for cardiology outpatient clinic review and cardiac CT-related outpatient referrals occurred in the SOC arm (p=0.01). 12-month MACE rates were similar between the two arms (7 (5.6%) in the CCTA arm and 8 (6.5%) in the SOC arm—log-rank p=0.78).

Conclusions

CCTA did not lead to reduced hospital LOS or cost, largely because these outcomes were influenced by the detection of ≥25% grade stenosis in a proportion of patients.

Trial registration number

NCT03583320.
Multivariate evaluation of prognostic markers in synovial sarcoma
Authors: Larque Ana-Belen , Lozano-Calderon Santiago , Cote Gregory M , Chen Yen-Lin , Hung Yin P , Deshpande Vikram , Nielsen G Petur , Chebib Ivan
Published: October 2022

Aims

Synovial sarcoma (SS) is an aggressive neoplasm but with varied clinical outcomes despite standard treatment protocols. Several clinicopathological features and immunohistochemical stains have been proposed as prognostic markers in SS. The aim of this study was to evaluate SS from a single institution for prognostically relevant clinicopathological and immunohistochemical factors.

Methods

We identified a single-institution cohort of SS with follow-up. Clinical and pathological factors examined included age, sex, tumour location, AJCC (American Joint Committee on Cancer) stage, tumour size, grade and status of surgical margins. Immunohistochemical staining for p16, p53, RB1, MYC, PTEN (phosphatase and tensin homologue), β-catenin, MDM2 and Ki67 proliferative index was performed on tissue microarray. Cox proportional hazard model was used for multivariate assessment of overall survival (OS) and disease-free survival (DFS).

Results

133 patients with SS met the inclusion criteria for our cohort, with 100 having complete dataset for all study covariates. On Cox regression multivariate analysis, location (axial vs extremity, p<0.001), AJCC stage (p<0.001), p16 expression (≥75%, p=0.021) were significantly associated with worse OS, whereas PTEN intensity (score 2, p<0.001) and p53 expression (null/≥75%, p=0.013) were correlated with improved OS. For DFS analysis, location (axial vs extremity, p=0.030), tumour size (≥5 cm, p=0.009) and MYC expression (≥33%, p=0.013) were associated with inferior outcome. Only PTEN intensity (score 2, p<0.001) correlated with improved DFS.

Conclusions

In reviewing numerous clinicopathological and immunohistochemical markers, this study shows that location, AJCC stage, p16, p53 and PTEN expression were prognostically significant in multivariate analysis for OS in a uniformly treated SS cohort. Location, tumour size, MYC and PTEN expression were significantly associated with DFS.
First communication on the efficacy of combined177Lutetium-PSMA with immunotherapy outside prostate cancer
Authors: Digklia Antonia , Boughdad Sarah , Homicsko Krisztian , Dromain Clarisse , Trimech Mounir , Dolcan Ana , Peters Solange , Prior John , Schaefer Niklaus
Published: October 2022

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy is a validated treatment option for patients with advanced prostate cancer. Although PSMA expression is not limited to prostate tissue, little is known about its relevance to other types of cancer. Here, we present a case report of a patient with uterine leiomyosarcoma that is progressing while on immunotherapy and treated with177Lu-PSMA radionuclide therapy. We report for the first time that177Lu-PSMA radionuclide therapy combined with immunotherapy outside of prostate cancer. We did observe post-treatment reduction of tumor growth rate, although we did not notice disease response based on RECIST criteria. We suggest that177Lu-PSMA treatment especially combined with immunotherapy may be an option for patients with cancer without other therapeutic options. Insights:177Lu-PSMA radionuclide therapy should be considered for any tumor stained positive for PSMA.
Language of violence: Do words matter more than we think?
Authors: Tatebe Leah C , Thomas Arielle , Regan Sheila , Stone Levon , Dicker Rochelle
Published: October 2022

Firearm violence is a leading cause of morbidity and mortality among young adults. Identification of intervention targets is crucial to developing and implementing effective prevention efforts. Hospital Violence Intervention Programs (HVIPs) have used a multiprong social care approach to mediate the cycle of interpersonal violence. One struggle continually encountered is how to change the conversation around the future. Speech patterns have been associated with health outcomes and overall behavior modification. During violence prevention efforts, young victims of violence say things such as ‘I’m living on borrowed time’ and ‘why should I worry about getting an education when I’ll likely die soon anyway?’ Such speech patterns may contribute to the cycle of violence and increase the likelihood of reinjury. Presented is a narrative review of the impact language has on health outcomes and how psychotherapy may be able to change thought patterns, alter language structure, and ultimately reduce risk of reinjury.

The biopsychosocial model of health posits that a person’s health is dictated by a combination of biological, psychological, and social factors. By understanding that language exists in the personal context, it can serve as both an indicator and a tool for targeted interventions. Cognitive–behavioral therapy (CBT) works by retraining thought and speech patterns to affect change in emotion, physiology, and behavior. It is proposed here that CBT could be used in the HVIPs’ multidisciplinary case management model by involving trained psychotherapists. Language is an important indicator of a patient’s psychological state and approach to life-changing decisions. As such, language alteration through CBT could potentially be used as a novel method of injury prevention. This concept has not before been explored in this setting and may be an effective supplement to HVIPs’ success.
Expression analysis of POSTN gene in ovine follicles
Authors: Lin Jiapeng , Liu Chunjie , Wang Liqin , Chen Ying , Li Xiaolin , Wu Yangsheng , Huang Juncheng
Published: October 2022

The purpose of this study was to explore the potential expression regularity of POSTN in ovarian tissue. In this study, the uterus, ovarian follicles, heart, liver, spleen, lung, kidney, and muscle tissues of Merino sheep (10) were collected and detected by Western blot, real-time quantitative polymerase chain reaction, immunohistofluorescence, and fluorescence staining, respectively. The expression of POSTN in various organizations was analyzed. The results showed that the POSTN in Merino sheep had close homology with Bos mutus and Bos taurus. The expression of POSTN was detected in the uterus, follicle, heart, liver, spleen, lung, kidney, and muscle tissue, among which the expression of POSTN was highest in ovarian tissue. In addition, the expression of POSTN gradually increased with the increase of follicle diameter, among which POSTN was highly expressed in the granulosa cells (GCs) of follicles. Meanwhile, POSTN were distributed throughout the nucleus and cytoplasm of GCs, suggesting that POSTN may be involved in the regulation of follicle development.
Feature representation improved Faster R-CNN model for high-efficiency pavement crack detection
Authors: Zhai Junzhi , Sun Zhaoyun , Huyan Ju , Li Wei , Yang Handuo
Published: October 2022

Two optimization methods are proposed to improve faster region-based convolutional neural network (Faster R-CNN), which are (1) restructuring Faster R-CNN's backbone network and the classification and regression (C&R) network using residual networks and (2) designing the feature ensemble structure for Faster R-CNN to combine the shallow with deep feature maps of the backbone. In addition, this paper proposed a method to evaluate the model's performance, which is pixel mean value ( Pmean) distribution of different channel feature maps, and quantitatively evaluate the feature representation capability of the model. Experimental results show that mean average precision (mAP) of the model optimized by the first method can reach 86.5%, which is 1.9% higher than that of baseline. However, mAP of the model optimized by the second method reaches 87.5%, which is 2.9% higher than the baseline model. The Pmean statistics of each channel feature map extracted by different backbones show that the model accuracy is higher when the Pmean of its channel feature maps is bigger, which can effectively improve the interpretability of the model accuracy.
Development of tree recruitment models for 10 species groups in the sugar maple-dominated mixed forests of eastern Canada
Authors: Rijal Baburam , Power Hugues , Auger Isabelle , Guillemette François , Bédard Steve , Schneider Robert
Published: October 2022

Individual tree recruitment is an important element needed to understand stand dynamics, as it influences both stand composition and productivity. Forest growth simulators usually include recruitment models. The quality of recruitment predictions can have long-term impacts on estimations of forest growth, ecosystem health and the commercial utility of managed forests. The main objective of this study was to develop a recruitment model for commercial-size trees (i.e., trees with a diameter at breast height > 9 cm) of 10 species groups using different dendrometric and environmental variables. The resulting model will be included in a growth simulator used to support forest management planning. We hypothesized that accounting for sapling density as a covariate would improve the recruitment model's predictive performance. Using empirical data from periodically measured permanent sample plots (1982–2019) located throughout the managed mixed hardwood forests of Quebec, we constructed models with and without sapling-related covariates and compared them on the basis of cross-validation model performance statistics. Our results show that including sapling density significantly improved model performance. From this, we conclude that adding sapling density as a covariate can significantly improve a recruitment model's predictive power for eastern mixed hardwood forests.
Neighbours in nodules: the interactions between Frankia sp. ACN10a and non-Frankia nodular endophytes of alder
Authors: Garneau Louis , Beauregard Pascale B. , Roy Sébastien
Published: October 2022

In the present study, we report the in vitro interactions between Frankia sp. ACN10a and non- Frankia nodular endophytes (NFNE) isolated from alder. The supernatant of NFNE grown in nitrogen-replete medium had neutral or negative effects on Frankia growth; none had a stimulatory effect. Inhibitory effects were observed for supernatants of some NFNE, notably Micromonospora, Pseudomonas, Serratia and Stenotrophomonas isolates. However, some NFNE– Frankia coculture supernatants could stimulate Frankia growth when used as a culture medium supplement. This was observed for supernatants of Frankia cocultured with Microvirga and S treptomyces isolates. In nitrogen-limited conditions, cocultures of Frankia with some NFNE, including some rhizobia and Cytobacillus, resulted in higher total biomass than Frankia-only cultures, suggesting cooperation, while other NFNE were strongly antagonistic. Microscopic observation of cocultures also revealed compromised Frankia membrane integrity, and some differentiation into stress resistance-associated morphotypes such as sporangia and reproductive torulose hyphae (RTH). Furthermore, the coculture of Frankia with Serratia sp. isolates resulted in higher concentrations of the auxinic plant hormone indole-3-acetic acid and related indolic compounds in the culture supernatant. This study sheds new light on the breadth of microbial interactions that occur amongst bacteria that inhabit the understudied ecological niche of the alder nodule.
Yeast communities before and after spontaneous fermentation of wine grapes: a case study from Nova Scotia
Authors: Bunbury-Blanchette Adele L. , Fan Lihua , English Marcia M. , Kernaghan Gavin
Published: October 2022

Wine fermentations are generally completed by the domestic yeast Saccharomyces cerevisiae, but many indigenous vineyard yeasts also influence wine flavour and aroma. Despite the flourishing wine industry in Nova Scotia, there has yet to be any systematic evaluation of these yeasts in Atlantic Canada. The yeast communities of pressed L'Acadie blanc grapes sampled from an organic vineyard in the Annapolis Valley in 2018 and 2019 were characterized before and after spontaneous fermentation by both Illumina and PacBio sequencing, to address and compare potential platform biases. Chemical and sensory evaluations were also conducted. Basidiomycete yeasts, including Vishniacozyma carnescens, Filobasidium globisporum, and Curvibasidium cygneicollum, dominated pre-fermentation diversity. Species of Saccharomyces made up ∼0.04% of sequences prior to fermentation, but 85%–100% after fermentation, with some replicates dominated by S. cerevisiae and some by S. uvarum. PacBio sequencing detected high proportions of Hanseniaspora uvarum, while Illumina sequencing did not. A better understanding of Nova Scotia vineyard yeast communities will allow local wine makers to make better use of non-traditional yeasts and spontaneous fermentations to produce high-quality wines unique to the region.
Diversity in genetic and downy mildew resistance among wild and mutagenized hops as revealed by single nucleotide polymorphisms and disease rating
Authors: Zaidi Mohsin , Somalraju Ashok , Ghose Kaushik , McCallum Jason , Mills Aaron , Fillmore Sherry , Fofana Bourlaye
Published: October 2022

Studies on wild and landrace hops from the Canadian Maritimes are scarce. This study was undertaken to broaden the genetic base of hops and to assess the reaction of the generated variants to downy mildew (DM) disease. A landrace hop (PE Royalty (P-RL)) and a commercial cultivar (Alpharoma) were mutagenized using ethylmethane sulphonate (EMS), and single nucleotide polymorphism (SNP) variations were determined using an amplicon sequencing genetic diversity study. A subset of wild types and a subset of mutagenized hops were inoculated with DM spores and rated for disease symptoms in a controlled environment. The data showed large EMS-induced genetic diversity in the target genes along with natural variations in the wild types. A diversity in DM resistance within the studied collection was also observed. The study showed DM tolerance in some P-RL landrace seedlings, suggesting that these P-RL landraces must have acquired and developed adaptation mechanisms to co-evolve with DM disease in the environment. Further, EMS-induced mutagenesis increased allelic variations that contributed to increased DM resistance in some seedlings. The data recommend the use of true hop seeds for increased genetic variability in breeding programs.
Impact of electron correlation on the light-induced demagnetization of elemental ferromagnetic metals
Authors: Barros Tomás , Tancogne-Dejean Nicolas , Berakdar Jamal , Marques Miguel A. L.
Published: October 2022

The local spin-density approximation (LSDA) is known to describe poorly the electronic structure of 3d transition metals, yet most density-functional-based ab-initio studies of ultra-fast demagnetization rely on it. One way to account for Coulomb correlations among the localized d electrons and go beyond LSDA is to include the effective correlation energy (or Hubbard) U. By doing so, we show here that electronic correlations lead to sizable changes of the laser-induced demagnetization of iron, cobalt, and nickel. We study how the various laser parameters, such as pulse duration or intensity, change the magnetization dynamics. It turns out that the total laser fluence is not suitable to quantify how much a laser pulse demagnetizes a material, as changes in pulse duration and shape influence significantly the outcome. The findings are traced back to the electronic structure of the material, and explained based on phase space for optical transitions.

Graphic abstract
Efficiency and stability analysis on nonlinear differential dynamical systems
Authors: Saqib Muhammad , Seadawy Aly R. , Khaliq Abdul , Rizvi Syed T. R.
Published: October 2022

The principle goal of the paper is to present proficient limited contrast finite difference schemes to execute on the nonlinear coupled partial differential system which emulate the overseeing differential framework. In this paper, more consideration is given to the exactness and security of the proposed numerical schemes by review consistency and union of the arrangement which can be seen from figures and information tables. For the nonlinear differential system, mesh independent results are expensive which are accommodated by the generation of block tridiagonal matrix structures (inherent properties of schemes) which are measured in terms of [Formula: see text] & [Formula: see text] norms which lead to a superb concurrence with the investigative arrangement.
Dynamical analysis in a piecewise smooth predator–prey model with predator harvesting
Authors: Hua Duo , Liu Xingbo
Published: October 2022

The aim of this paper is to study the dynamical behaviors of a piecewise smooth predator–prey model with predator harvesting. We consider a harvesting strategy that allows constant catches if the population size is above a certain threshold value (to obtain predictable yield) and no catches if the population size is below the threshold (to protect the population). It is shown that boundary equilibrium bifurcation and sliding–grazing bifurcation can happen as the threshold value varies. We provide analytical analysis to prove the existence of sliding limit cycles and sliding homoclinic cycles, the coexistence of them with standard limit cycles. Some numerical simulations are given to demonstrate our results.
Unique Considerations for Paediatric Proximal Phalanx Fractures
Authors: CHAUDHRY Sonia
Published: October 2022

Paediatric hand fracture care presents unique considerations and challenges. The proximal phalanx is the most injured location. This review details pearls for the examination of the injured paediatric hand, immobilisation considerations and treatment strategies. Over-treatment can lead to unnecessary stiffness, missed activities, increased healthcare costs or unnecessary surgical morbidity. Undertreatment can promote malunion and dysfunction. Fracture patterns discussed include those of the phalangeal head, neck, shaft and base. The concepts covered will help optimise the evaluation and treatment of children with injured proximal phalanges.

Level of Evidence: Level V (Therapeutic)
Severe Life-Threatening Sepsis Complicating Infected Thumb Carpometacarpal Arthroplasty
Authors: KALIMIAN Tal , KRAMER Moti , DREXLER Michael , FARKASH Uri
Published: October 2022

Thumb Carpometacarpal (CMC) total joint arthroplasty is commonly performed with increasing numbers worldwide. We present a case of Prosthetic Joint Infection (PJI) leading to severe septic shock and disseminated septic emboli 8 months following uneventful thumb CMC arthroplasty. Such extensive and life-threatening infection following thumb CMC arthroplasty has not been reported.

Level of Evidence: Level V (Therapeutic)
Accuracy Configurable Adders with Negligible Delay Overhead in Exact Operating Mode
Authors: Ebrahimi-Azandaryani Farhad , Akbari Omid , Kamal Mehdi , Afzali-Kusha Ali , Pedram Massoud
Published: October 2022

In this paper, two accuracy configurable adders capable of operating in approximate and exact modes are proposed. In the adders, which include a block-based carry propagate and a parallel prefix structure, the carry chains are cut off in the approximate mode limiting the carry chain depth to two blocks. In the case of parallel prefix adder, we propose a special carry generate tree equipped with a power gating means. In both of the proposed structures, the critical paths of the adders are not increased in the exact operating mode. Thus, the main objective of proposing these approximate adder structures is to present an accuracy configurable adder structure whose delay in the exact mode is almost the same as an exact adder. The efficacies of the proposed accuracy configurable adders are compared with some state-of-the-art adder structures using a 15nm CMOS technology. In addition, their efficacies are evaluated in two error-resilient applications. These studies show that the proposed carry-propagate adder has 22% (51%) lower energy consumption (error rate) compared to the best prior works. Also, the proposed parallel prefix adder provides, on average, 20% lower energy consumption compared to the exact parallel prefix adders.
Learning-based Phase-aware Multi-core CPU Workload Forecasting
Authors: Lozano Erika Susana Alcorta , Gerstlauer Andreas
Published: October 2022

Predicting workload behavior during workload execution is essential for dynamic resource optimization in multi-processor systems. Recent studies have proposed advanced machine learning techniques for dynamic workload prediction. Workload prediction can be cast as a time series forecasting problem. However, traditional forecasting models struggle to predict abrupt workload changes. These changes occur because workloads are known to go through phases. Prior work has investigated machine-learning-based approaches for phase detection and prediction, but such approaches have not been studied in the context of dynamic workload forecasting. In this article, we propose phase-aware CPU workload forecasting as a novel approach that applies long-term phase prediction to improve the accuracy of short-term workload forecasting. Phase-aware forecasting requires machine learning models for phase classification, phase prediction, and phase-based forecasting that have not been explored in this combination before. Furthermore, existing prediction approaches have only been studied in single-core settings. This work explores phase-aware workload forecasting with multi-threaded workloads running on multi-core systems. We propose different multi-core settings differentiated by the number of cores they access and whether they produce specialized or global outputs per core. We study various advanced machine learning models for phase classification, phase prediction, and phase-based forecasting in isolation and different combinations for each setting.

We apply our approach to forecasting of multi-threaded Parsec and SPEC workloads running on an eight-core Intel Core-i9 platform. Our results show that combining GMM clustering with LSTMs for phase prediction and phase-based forecasting yields the best phase-aware forecasting results. An approach that uses specialized models per core achieves an average error of 23% with up to 22% improvement in prediction accuracy compared to a phase-unaware setup.
Surface Damage Identification for Heritage Site Protection: A Mobile Crowd-sensing Solution Based on Deep Learning
Authors: Meklati Safia , Boussora Kenza , Abdi Mohamed El Hafedh , Berrani Sid-Ahmed
Published: October 2022

This article addresses the general problem of built heritage protection against both deterioration and loss. To continuously monitor and update the structural health status, a crowd-sensing solution based on powerful and automatic deep learning technique is proposed. The aim of this solution is to get rid of the limitations of manual and visual damage detection methods that are costly and time-consuming. Instead, automatic visual inspection for damage detection on walls is efficiently and effectively performed using an embedded Convolutional Neural Network (CNN). This CNN detects the most frequent types of surface damage on wall photos. The study has been conducted in the Kasbah of Algiers where the four following types of damages have been considered: Efflorescence, spall, crack, and mold. The CNN is designed and trained to be integrated into a mobile application for a participatory crowd-sensing solution. The application should be widely and freely deployed, so any user can take a picture of a suspected damaged wall and get an instant and automatic diagnosis through the embedded CNN. In this context, we have chosen MobileNetV2 with a transfer learning approach. A set of real images have been collected and manually annotated and have been used for training, validation, and test. Extensive experiments have been conducted to assess the efficiency and the effectiveness of the proposed solution, using a 5-fold cross-validation procedure. Obtained results show in particular a mean weighted average
precision
of
0.868
± 0.00862 (with a 99% of confidence level) and a mean weighted average
recall
of
0.84
± 0.00729 (with a 99% of confidence level). To evaluate the performance of MobileNetV2 as a feature extractor, we conducted a comparative study with other small backbones. Further analysis of CNN activation using Grad-Cam has also been done. Obtained results show that our method remains effective even when using a small network and medium- to low-resolution images. MobileNetV2-based CNN size is smaller, and computational cost better, compared to the other CNNs, with similar performance results. Finally, detected surface damages have also been plotted on a geographic map, giving a global view of their distribution.