bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetotellurics (MT) and Gravity Study of a Possible Active Fault in Southern Garut, West Java, Indonesia
Authors: Arisbaya Ilham , Wijanarko Edy , Warsa  , Sumintadireja Prihadi , Sudrajat Yayat , Handayani Lina , Mukti M. Ma'ruf , Grandis Hendra
Published: April 2023

In recent years, dozen low-intensity earthquakes occurred in southern Garut, West Java Indonesia; two of them were reported destructive. However, those shallow earthquake clusters are hardly associated with well-known active faults in the area. Hence, we conducted 3D gravity combined with 2D magnetotellurics (MT) inversions to study the subsurface. Gravity and MT modeling confirm a basin with around 5 km depth consisting of two subbasins separated by a NE-SW trending local-high ridge. The local high coincides with the magmatic intrusion in geothermal fields and aligns with a series of volcanic bodies’ lineament observed on the surface. We interpret this structural high as a preexisting fault that serves as a magma pathway in the tectonomagmatic interaction. Shallow low-magnitude seismicity in the southern Garut area tends to occur in the resistive bodies. We interpret that heat from the cooling magmatic intrusion may decrease the effective fault-normal stress of the rocks, leading to a decrease in fault failure resistance and may initiate rupture. The resistivity structure around the initial rupture may affect whether or not the nucleation will end up as a large-magnitude earthquake. Furthermore, the unconsolidated young volcanic cover in this area could amplify ground shaking when earthquake occurs that might lead to more extensive damage.
Biodiesel Production through Electrolysis Using an Ionic Liquid, 1-Ethyl-3-Methylimidazolium Chloride as a Supporting Electrolyte
Authors: Aregawi Beyene Hagos , Nguyen Hoang Chinh , Fu Chun-Chong , Ong Hwai Chyuan , Barrow Colin J. , Su Chia-Hung , Wu Shao-Jung , Juan Horng-Yi , Wang Fu-Ming
Published: April 2023

Electrolysis is a promising approach for biodiesel production. However, low electrical conductivity of a reaction mixture results in a low reaction rate. Thus, this study developed a novel catalyst-free electrolysis process using an ionic liquid as a supporting electrolyte for biodiesel production. Various ionic liquids were assessed, and 1-ethyl-3-methylimidazolium chloride ([Emim]Cl) exhibited the highest electrical conductivity (4.59 mS/cm) and the best electrolytic performance for transesterification. Electrolysis in the presence of [Emim]Cl was subsequently optimized using response surface methodology to maximize biodiesel yield. A maximum biodiesel yield of 97.76% was obtained under the following optimal reaction conditions: electrolysis voltage, 19.42 V; [Emim]Cl amount, 4.43% (

w
/
w

); water content, 1.62% (

w
/
w

); methanol to oil molar ratio, 26.38 : 1; and reaction time, 1 h. Notably, [Emim]Cl could be efficiently reused for at least three cycles with a corresponding biodiesel yield of 94.81%. Moreover, the properties of the synthesized biodiesel complied with EN and ASTM standards. The findings of this study indicate that catalyst-free electrolysis using [Emim]Cl as a supporting electrolyte is an eco-friendly and efficient method for biodiesel production.
Novel Echocardiographic Metrics Predict Tricuspid Insufficiency in Pediatric Ebstein Anomaly
Authors: Liu Wei , Wen Chen , Shentu Jin , Zhang Yuqi , Zhu Zhongqun , Chen Lijun , Chen Huiwen
Published: April 2023

Objectives. The tricuspid anterior leaflet is considered important in most repair techniques for Ebstein anomaly (EA). We aim to assess the anterior leaflet morphology using novel metrics and investigate the association of the morphology with recurrent moderately severe or greater tricuspid regurgitation (TR). Methods. Seventy-four paediatric patients with EA undergoing cone reconstruction (CR) between 2010 and 2021 were included. Anterior leaflet mobility (ALM) and anterior leaflet length (ALL) were remeasured on preoperative 2D echocardiography. The prediction accuracies of ALM and ALL-I (ALL indexed to body surface area) for recurrent TR were evaluated using receiver operating characteristic (ROC) curve analyses. Results. The median age of patients was 3.3 years (interquartile range, 1.9–7.1 years). Both ALM and ALL-I correlated with the Carpentier type and GOSH score. Nine patients (12.2%) developed recurrent TR during the one-year follow-up. By univariable logistic regression analyses, ALM (odds ratio [OR], 0.89; 95% CI [confidence interval], 0.82–0.96;

p

 = 0.003) and ALL-I (OR, 1.39; 95% CI, 1.08–1.78;

p

 = 0.011) were risk factors for recurrent TR. ROC curve analyses showed that ALM (AUC = 0.81) and ALL-I (AUC = 0.77) had better predictive performance for recurrent TR compared with the GOSH score (AUC = 0.68), the Carpentier type (AUC = 0.67), and preoperative TR severity (AUC = 0.58), and the combinations of ALM and ALL-I (AUC = 0.87) improved the predictive performance compared with ALM or ALL-I alone. Conclusions. ALM and ALL-I can help optimize evaluation in the anterior leaflet morphology and predict recurrent TR after CR in pediatric EA.
Characteristics of Biofoam Cups Made from Sugarcane Bagasse with Rhizopus oligosporus as Binding Agent
Authors: Indarti Eti , Muliani Sri , Yunita Dewi
Published: April 2023

This study is aimed at producing a biofoam cup made from sugarcane bagasse with tempeh mold (Rhizopus oligosporus). Soybean flour (SF) was added to promote the growth of mycelia, which could bind the bagasse fiber matrix. The main materials were whole bagasse (B) and depithed bagasse (DB). The SF weight ratios to bagasse were 1 : 1 (SF1) and 1.5 : 1 (SF1.5). Therefore, the studied specimens were labeled B-SF1, DB-SF1, B-SF1.5, and DB-SF1.5. All biofoam cups were analyzed for their physical properties (water absorption and porosity), mechanical properties (puncture and compressive strengths), biodegradability, and thermal properties (thermogravimetric analysis). The lowest water absorption rates were obtained from the B biofoam cups (

23
%
±
2.45
%

) and the SF1.5 biofoam cups (

25.83
%
±
5.19
%

). Both B-SF1 and B-SF1.5 had lower porosity (

8.72
%
±
0.88
%

and

10.77
%
±
1.54
%

, respectively) than the DB biofoam cups. Moreover, the B biofoam cups had smoother biofoam surfaces, smaller voids, and lower porosity compared with the DB samples. However, the DB biofoam cups showed the highest puncture strength (

2.95
±
0.37

 kg cm−2) among all samples. Nevertheless, the B-SF1.5 biofoam cup had the highest compressive strength (

3.98
±
0.39

 MPa) and the DB-SF1.5 exhibited the slowest degradation rate (

27
%
±
0.7
%

) after 14 days of soil burial. The highest thermal stability was obtained from B-SF1.5, which had a thermal degradation temperature of 264°C. Overall, B-SF1.5 had the smoothest surface, good thermal stability, and high compressive strength.
Ellagic Acid Treatment Improves Postharvest Quality of Tomato Fruits by Enhancing the Antioxidant Defense System
Authors: Cao Jun-Xuan , Wang Tong , Li Yaping , Cao Shuqing , Fan Ting-Ting
Published: April 2023

Ellagic acid (EA) is a bioactive polyphenol compound with numerous biological activities, such as anti-inflammatory, antiestrogenic, antioxidant, and anticancer activities. In this research, we investigated the effect of postharvest tomato fruits with EA treatment. Our results showed that at 25°C for 20 days, compared to a control group, the weight loss rate, titratable acidity, and soluble solid concentration of tomato fruits treated with 50 μM EA were lower. The content of soluble protein in the EA-treated group was approximately 1.65 times higher than in the control group, and EA treatment greatly inhibited the changes in lycopene and vitamin C content. Moreover, EA treatment reduced malondialdehyde content, electrolyte leakage, and the production of reactive oxygen species. Furthermore, EA treatment upregulated the expression of antioxidant-related genes and induced the activities of the antioxidant enzyme. In summary, our results showed that EA could retard senescence and preserve the quality characteristics of harvested tomato fruits via enhancing the antioxidant responses.
In-Hospital Mortality and Its Predictors among Hospitalized Diabetes Patients: A Prospective Observational Study
Authors: Eyob Tediso Dereje , Bekele Daba Fekede , Ayele Mega Teshale
Published: April 2023

Background. Diabetes mellitus (DM) is one of the leading health emergencies of the 21st century and among the top ten causes of death among adults globally in 2017. Although Ethiopia has been victimized by the growing prevalence of DM, data regarding in-hospital mortality among admitted diabetic patients in Ethiopia, specifically in Jimma Medical Center (JMC), are lacking. Objective. The aim of the study is to assess in-hospital mortality and its predictors among DM patients admitted to Jimma Medical Center. Methods. A hospital-based prospective observational study was employed involving 120 diabetes patients admitted to JMC from October 01, 2020, to June 30, 2021. Data were collected on variables related to the patient, disease, medication, and clinical outcomes. Data were entered into Epidata version 4.6.0.4 for cleaning and exported to SPSS version 23.0 for analysis. Kaplan–Mayer and cox-regression analyses were used to compare the survival experience and to determine the predictors of clinical outcomes, respectively. Hazard ratio with its two-sided

p

value <0.05 was considered to declare the statistical significance. Result. Of 120 DM patients, 81 (67.5%) of them were males. The in-hospital mortality was 13.34% (16/120). Rural residence (AHR: 3.46; 95% CI (1.12, 9.81)), age (AHR: 1.03; 95% CI: (1.001, 1.059)), admission with diabetic ketoacidosis (AHR: 5.01; 95% CI (1.12, 21.88)), and multiple comorbidities: five comorbidities (AHR: 9.65; 95% CI (1.07, 19.59)) and six comorbidities (AHR: 14.02; 95% CI (1.74, 21.05)) were independently associated with in-hospital mortality. On the other hand, exposure to nonantidiabetic medications decreased the hazard of mortality by 86.5% (AHR: 0.135; 95% CI (0.04, 0.457)). Conclusion. This study showed the rate of in-hospital mortality was noticeably high. The study showed that rural residence, age, DKA, and having comorbidities (five and six) were the statistically significant predictors of in-hospital mortality. In contrast, the use of nonantidiabetic medications such as statins, ASA, and other antihypertensive agents before admission remained protective. Thus, proper strategies have to be devised to improve in-hospital mortality among admitted DM patients.
Exsolved Ru on BaCexOy Catalysts for Thermochemical Ammonia Synthesis
Authors: Badakhsh Arash , Vieri Hizkia Manuel , Sohn Hyuntae , Yoon Sung Pil , Choi Sun Hee
Published: April 2023

Ammonia (NH3) is a carbon-free and hydrogen-rich (17.8 wt% H2) chemical that has the potential to revolutionize the energy sector. Compared with hydrogen (H2), NH3 can be easily liquefied, stored, and transported globally. However, the conventional thermocatalytic process to synthesize NH3 accounts for 2% of global energy consumption and 1.2% of CO2 emissions annually. To make the process further efficient, new catalysts must be developed to allow for NH3 synthesis in milder conditions with high thermal stability. To this end, we have developed ruthenium (Ru) supported on perovskite (BaCexOy) via a ball-milling-assisted exsolution method that allows for a more tunable morphology. Reactivity is compared with the catalyst prepared via the conventional impregnation technique. The as-synthesized catalysts are characterized by XRD, H2-TPR, TEM, XPS, and APT. The NH3 synthesis is carried out in a packed-bed tube reactor thermochemically. Using N2 instead of Ar as the carrier gas during exsolution can favour reactivity by increasing active sites and perhaps improving metal-support interaction. The impregnated sample shows higher reactivity than the exsolved catalyst; however, the long-term durability is slightly better using the exsolved catalyst. Finally, APT results interestingly show that the exsolved catalyst is more resistant to hydride formation and hydrogen poisoning, which is one of the main deactivation mechanisms for such metallic catalysts.
Supplementary Table S9 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: April 2023

Output of genome-scale shRNA screen in HKO2.
Supplementary Figures S1-S5 from TGFβ Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response
Authors: Han Jianfeng , Chen Xilin , Chu Jianhong , Xu Bo , Meisen Walter H. , Chen Lichao , Zhang Lingling , Zhang Jianying , He Xiaoming , Wang Qi-En , Chiocca E. Antonio , Kaur Balveen , Caligiuri Michael A. , Yu Jianhua
Published: April 2023

TGFβ pretreatment decreases NK cell cytotoxicity against o-HSV infected glioblastoma cell lines and patient-derived glioblastoma stem-like cells (S1); TGFβ mediated inhibition of NK cell and macrophages/microglia intracranial infiltration persists 2 days after oHSV infection (S2); TGFβ pretreatment decreases spleen NK cell activity in 4C8 B6D2F1 mouse model in the presence of oHSV (S3); Virus titer, macrophages/microglia infiltration levels remain similar after NK cell depletion with an asialo-GM1 antibody (S4); A single dose TGFβ treatment in the absence of oHSV is not oncogenic (S5).
Supplementary Figure Legends from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: April 2023

Supplementary Figure Legends from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Supplemental Figure 2 from Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry
Authors: Guenther Sabine , Muirhead Laura J. , Speller Abigail V.M. , Golf Ottmar , Strittmatter Nicole , Ramakrishnan Rathi , Goldin Robert D. , Jones Emrys , Veselkov Kirill , Nicholson Jeremy , Darzi Ara , Takats Zoltan
Published: April 2023

Supplemental Figure 2. Plots showing the logarithmic intensity distribution of several highly predictive compounds in normal glandular tissue and tumors of different grade and hormone receptor status.
Supplemental Figure S2 from Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat
Published: April 2023

CAIX activity assay.
Supplemental Figure S1 from Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat
Published: April 2023

Conditioned media antibody array and ELISA analyses.
Supplementary Figures S1-S5 from Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells
Authors: Salimian Rizi Bahar , Caneba Christine , Nowicka Aleksandra , Nabiyar Ahmad W. , Liu Xinran , Chen Kevin , Klopp Ann , Nagrath Deepak
Published: April 2023

Supplementary Figures S1-S5. Arginase does not regulate arginine levels in OVCAs and ECAs (S1); O-ASCs induce reduced viability of cancer cells deprived of arginine (S2); L-arginase depletes arginine within the media (S3); Cancer cells induce glucose uptake and lactate secretion of O-ASCs and vice versa (S4); NO induces resistance of cancer cells to paclitaxel (S5).
Supplementary Figure 2| Circulating Hematopoietic Cells do not contribute to tumor blood vessels. from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Authors: Corey Daniel M. , Rinkevich Yuval , Weissman Irving L.
Published: April 2023

Flow cytometry plots from wild-type mice reconstituted with cyan-fluorescent-protein hematopoietic stem cells CFP-HSCs showing the absence of CFP-HSC derived cells in blood vessels. (a) Flow cytometry plots showing gating of B16 tumors after enzymatic digestion. (b) Within the high expressing CD31 and CD144 subset, we find no contribution from CFP-HSCs (lower panel). (c) In contrast, within the CD45+ CD31-VeCad- subset representing the hematopoietic component of the tumor stroma, progeny of CFP-HSCs are detected. (d) Histologic section of bone marrow showing full blood chimerism 3 months after transplant.
Supplemental figure legends from Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte–Endothelial Recognition to Foster Tumor Immune Escape
Authors: Corey Daniel M. , Rinkevich Yuval , Weissman Irving L.
Published: April 2023

Supplemental figure legends
Supplementary Figure Legends from Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients
Authors: Osman Abdullah A. , Neskey David M. , Katsonis Panagiotis , Patel Ameeta A. , Ward Alexandra M. , Hsu Teng-Kuei , Hicks Stephanie C. , McDonald Thomas O. , Ow Thomas J. , Alves Marcus Ortega , Pickering Curtis R. , Skinner Heath D. , Zhao Mei , Sturgis Eric M. , Kies Merrill S. , El-Naggar Adel , Perrone Federica , Licitra Lisa , Bossi Paolo , Kimmel Marek , Frederick Mitchell J. , Lichtarge Olivier , Myers Jeffrey N.
Published: April 2023

Supplementary Figure Legends. Expression of p53 target genes is impaired following cisplatin treatment in HNSCC harboring mutant TP53; TP53 knockdown illustrates both loss and gain of function in vitro in HNSCC cells;Effect of cisplatin therapy on tumor growth and survival in an orthotopic nude mouse model of oral tongue cancer harboring TP53 mutations presented as area under the growth curve (AUC).
Supplementary Methods and References from A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence
Authors: Acevedo Mariana , Vernier Mathieu , Mignacca Lian , Lessard Frédéric , Huot Geneviève , Moiseeva Olga , Bourdeau Véronique , Ferbeyre Gerardo
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure Legends from A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence
Authors: Acevedo Mariana , Vernier Mathieu , Mignacca Lian , Lessard Frédéric , Huot Geneviève , Moiseeva Olga , Bourdeau Véronique , Ferbeyre Gerardo
Published: April 2023

Legend for Supplementary Figures S1-S7.
Supplemental table 1 from p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia
Authors: Hendley Audrey M. , Wang Yue J. , Polireddy Kishore , Alsina Janivette , Ahmed Ishrat , Lafaro Kelly J. , Zhang Hao , Roy Nilotpal , Savidge Samuel G. , Cao Yanna , Hebrok Matthias , Maitra Anirban , Reynolds Albert B. , Goggins Michael , Younes Mamoun , Iacobuzio-Donahue Christine A. , Leach Steven D. , Bailey Jennifer M.
Published: April 2023

This table provides a description of antibodies used in this study.
Figure S3 from S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
Authors: Rizza Salvatore , Montagna Costanza , Cardaci Simone , Maiani Emiliano , Di Giacomo Giuseppina , Sanchez-Quiles Virginia , Blagoev Blagoy , Rasola Andrea , De Zio Daniela , Stamler Jonathan S. , Cecconi Francesco , Filomeni Giuseppe
Published: April 2023

SDH-generated superoxide is the upstream mediator of α-TOS-induced cell death in siGSNOR HepG2 cells.
Supplemental Tables S1-S2 from Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation
Authors: D'Armiento Jeanine , Shiomi Takayuki , Marks Sarah , Geraghty Patrick , Sankarasharma Devipriya , Chada Kiran
Published: April 2023

Tsc2+/- extra-renal tumorigenesis is HMGA2 dependent (S1); Summary of human AML LOH analysis (S2).
Supplemental Figure S2 from Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation
Authors: D'Armiento Jeanine , Shiomi Takayuki , Marks Sarah , Geraghty Patrick , Sankarasharma Devipriya , Chada Kiran
Published: April 2023

Tuberin is present in all Tsc2+/- mesenchymal tumors.
Supplemental Figure S1 from Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation
Authors: D'Armiento Jeanine , Shiomi Takayuki , Marks Sarah , Geraghty Patrick , Sankarasharma Devipriya , Chada Kiran
Published: April 2023

HMGA2 and IGF2BP2 expression in Tsc2+/- tumor tissue.
Supplementary Table S2 from Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression
Authors: Linn Douglas E. , Penney Kathryn L. , Bronson Roderick T. , Mucci Lorelei A. , Li Zhe
Published: April 2023

Supplementary Table S2. Gene sets significantly (FDR q-val<0.25) enriched in T-delta-Erg/Pten-null HG-PINs compared to Pten-null HG-PINs.
Supporting data Fig 4A from Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response
Authors: Conery Andrew R. , Centore Richard C. , Spillane Kerry L. , Follmer Nicole E. , Bommi-Reddy Archana , Hatton Charlie , Bryant Barbara M. , Greninger Patricia , Amzallag Arnaud , Benes Cyril H. , Mertz Jennifer A. , Sims Robert J.
Published: April 2023

This file contains source data for the graph in Figure 4A (GI50 and expression values for each of the genes in 245 cell lines).
Supplementary Tables 1 through 3, Supplementary Figures 1 through 10 from Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Authors: Bräutigam Lars , Pudelko Linda , Jemth Ann-Sofie , Gad Helge , Narwal Mohit , Gustafsson Robert , Karsten Stella , Carreras Puigvert Jordi , Homan Evert , Berndt Carsten , Berglund Ulrika Warpman , Stenmark Pål , Helleday Thomas
Published: April 2023

Table S1: The redox status of the cell correlates with sensitivity to MTH1 inhibition. Table S2: Data collection and refinement statistics. Table S3: Kinetic parameters of zfMTH1. Table S4: Primer sequences. Figure S1: BSO treatment sensitizes U2OS and U343 cells against MTH1 inhibition. Figure S2: pre-treatment with PEG-catalase protects cancer cells against MTH1 inhibition. Figure S3: Alignment of human and zebrafish MTH1. Figure S4: Purification of zebrafish MTH1. Figure S5: Electron density for TH588 in the structure of Zebrafish MTH1. Figure S6: knock-down of VHL in HAEB cells sensitizes to the MTH1 inhibitor TH588. Figure S7: TH588 is well tolerated of zebrafish embryos. Figure S8: Expression of MTH1 in VHL knock-out background. Figure S9: Experimental setup for DMOG exposure of zebrafish embryos. Figure S10: ZebROS exposed to reducing and oxidizing agent.
Supplementary Figure S4 from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: April 2023

Decrease of PR55Î± expression in pancreatic cancer cells inhibits tumor growth.
Supplementary Figure S6 from Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation
Authors: Prabhu Varun V. , Hong Bo , Allen Joshua E. , Zhang Shengliang , Lulla Amriti R. , Dicker David T. , El-Deiry Wafik S.
Published: April 2023

Prodigiosin-mediated p53 pathway restoration and cell death involves c-Jun activation.
Supplementary Figure S7 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: April 2023

Cell cycle analysis of T3M-1 Cl-10 cells expressing various proteins
Supplementary Figures 1 through 5 from Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
Authors: Cheng Chun-Ting , Kuo Ching-Ying , Ouyang Ching , Li Chien-Feng , Chung Yiyin , Chan David C. , Kung Hsing-Jien , Ann David K.
Published: April 2023

Supplementary Figure S1. KAP1 transcript level is positively associated with some of mitochondrial complex genes expression in breast cancer patients. Supplementary Figure S2. KAP1 overexpression is associated with breast cancer poor prognosis. Supplementary Figure S3. p38MAPK, but not AMPK or ATM, activates metabolic stress-induced KAP1 phosphorylation at Ser473. Supplementary Figure S4. Time-dependent alterations of Mitochondrial dynamics upon glucose depletion. Supplementary Figure S5. S473A-KAP1 promotes mitochondrial network and sensitizes MDA-MB-231/shKAP1 cells to glucose starvation.
Supplementary Figure S11 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: April 2023

Validation of shRNAs targeted to DLX3 or HRK
Supplementary Figure S4 from STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: April 2023

HeLa cells were transfected with 10 pmol/1.5 x 105 cells of human STAT3-specific siRNA (#8 or 9) or mock siRNA.
Supplementary Table S2 from HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Authors: Li Yinghui , Wang Zhen , Shi Hui , Li Hang , Li Leilei , Fang Runping , Cai Xiaoli , Liu Bowen , Zhang Xiaodong , Ye Lihong
Published: April 2023

The primers used in this study.
Supplementary methods from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment
Authors: Koyama Shohei , Akbay Esra A. , Li Yvonne Y. , Aref Amir R. , Skoulidis Ferdinandos , Herter-Sprie Grit S. , Buczkowski Kevin A. , Liu Yan , Awad Mark M. , Denning Warren L. , Diao Lixia , Wang Jing , Parra-Cuentas Edwin R. , Wistuba Ignacio I. , Soucheray Margaret , Thai Tran , Asahina Hajime , Kitajima Shunsuke , Altabef Abigail , Cavanaugh Jillian D. , Rhee Kevin , Gao Peng , Zhang Haikuo , Fecci Peter E. , Shimamura Takeshi , Hellmann Matthew D. , Heymach John V. , Hodi F. Stephen , Freeman Gordon J. , Barbie David A. , Dranoff Glenn , Hammerman Peter S. , Wong Kwok-Kin
Published: April 2023

This file contains detailed information about the methods in the manuscript. These include: a list of clone names for all the antibodies, gating method for FACS analysis and sorting, method for mouse RNA sequencing data analysis and human gene expression and proteomic data analysis (CCLE, TCGA and PROSPECT), method for cytokine/chemokine analysis from BAL fluid and culture media.
Supplemental Figure Legends from EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
Authors: Lim Seung-Oe , Li Chia-Wei , Xia Weiya , Lee Heng-Huan , Chang Shih-Shin , Shen Jia , Hsu Jennifer L. , Raftery Daniel , Djukovic Danijel , Gu Haiwei , Chang Wei-Chao , Wang Hung-Ling , Chen Mong-Liang , Huo Longfei , Chen Chung-Hsuan , Wu Yun , Sahin Aysegul , Hanash Samir M. , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: April 2023

Supplementary Figure S1. EGF signaling enhances aerobic glycolysis in TNBC cells. Supplementary Figure S2. PKM2 is a novel binding partner of EGFR and its activity is inhibited by EGFR via Tyr phosphorylation. Supplementary Figure S3. EGFR reprograms cancer cell metabolism by PKM2 phosphorylation in TNBC cells. Supplementary Figure S4. Upregulation of HK2 expression by EGF signaling also contributes to aerobic glycolysis in TNBC cells. Supplementary Figure S5. Glycolysis metabolite, F1,6BP, binds directly to and enhances the activity of EGFR. Supplementary Figure S6. The combination of EGFR and glycolysis inhibitors synergistically suppresses TNBC cell proliferation. Supplementary Figure S7. EGF signaling-induced lactate inhibits cytotoxic T cell activity in TNBC cells.
Supplementary Figure S2 from Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Authors: Hirata Hidenari , Sugimachi Keishi , Komatsu Hisateru , Ueda Masami , Masuda Takaaki , Uchi Ryutaro , Sakimura Shotaro , Nambara Sho , Saito Tomoko , Shinden Yoshiaki , Iguchi Tomohiro , Eguchi Hidetoshi , Ito Shuhei , Terashima Kotaro , Sakamoto Katsumi , Hirakawa Masakazu , Honda Hiroshi , Mimori Koshi
Published: April 2023

FBP1 expression and mutational profiles across 234 HCC cases from The Cancer Genome Atlas.
Supplementary figures 10-11 from CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma
Authors: Walton Josephine , Blagih Julianna , Ennis Darren , Leung Elaine , Dowson Suzanne , Farquharson Malcolm , Tookman Laura A. , Orange Clare , Athineos Dimitris , Mason Susan , Stevenson David , Blyth Karen , Strathdee Douglas , Balkwill Frances R. , Vousden Karen , Lockley Michelle , McNeish Iain A.
Published: April 2023

Figures S10-S11: Quantitative F4/80 staining; Whole cytokine array image with array layout
Figure S5 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker
Authors: Bressy Christian , Lac Sophie , Nigri Jérémy , Leca Julie , Roques Julie , Lavaut Marie-Nöelle , Secq Véronique , Guillaumond Fabienne , Bui Thi-Thien , Pietrasz Daniel , Granjeaud Samuel , Bachet Jean-Baptiste , Ouaissi Mehdi , Iovanna Juan , Vasseur Sophie , Tomasini Richard
Published: April 2023

Measurement of Schwann cell differentiation through JAK/STAT pathway following LIF induction. The staining of 2 differentiation markers (S100 and Pou3F2) were validated in human PDA samples (A) then used on sNF96.2 cells following conditioned media incubation using or not AG490 aor SC144 inhibitors (B).
Table S1 from Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response
Authors: Greene James M. , Levy Doron , Herrada Sylvia P. , Gottesman Michael M. , Lavi Orit
Published: April 2023

Survival curves of two global cell density conditions, 10% and 80%
Figure S2 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker
Authors: Bressy Christian , Lac Sophie , Nigri Jérémy , Leca Julie , Roques Julie , Lavaut Marie-Nöelle , Secq Véronique , Guillaumond Fabienne , Bui Thi-Thien , Pietrasz Daniel , Granjeaud Samuel , Bachet Jean-Baptiste , Ouaissi Mehdi , Iovanna Juan , Vasseur Sophie , Tomasini Richard
Published: April 2023

Schematic representation of experimental protocols for (A) the co-culture method in order to produce specific conditioned media used in following migration assay or ELISA tittering as for (B) the migration assay method for the measurement of sNF96.2 migration abilities.
Figure S1 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker
Authors: Bressy Christian , Lac Sophie , Nigri Jérémy , Leca Julie , Roques Julie , Lavaut Marie-Nöelle , Secq Véronique , Guillaumond Fabienne , Bui Thi-Thien , Pietrasz Daniel , Granjeaud Samuel , Bachet Jean-Baptiste , Ouaissi Mehdi , Iovanna Juan , Vasseur Sophie , Tomasini Richard
Published: April 2023

Measurement of LIF mRNA level in normal and tumoral human fibroblasts by RT-QPCRs.
Supplementary Figure Legends from Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response
Authors: Greene James M. , Levy Doron , Herrada Sylvia P. , Gottesman Michael M. , Lavi Orit
Published: April 2023

Description of Figures S1, S2, and Movie S1
Supplementary Fig S1 from Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[18F]Fluorothymidine in Preclinical Models of Lung Cancer
Authors: Schelhaas Sonja , Held Annelena , Wachsmuth Lydia , Hermann Sven , Honess Davina J. , Heinzmann Kathrin , Smith Donna-Michelle , Griffiths John R. , Faber Cornelius , Jacobs Andreas H.
Published: April 2023

Outline of the experimental schedule pursued.
Supplementary Tables 1-4 from Targeting FBW7 as a Strategy to Overcome Resistance to Targeted Therapy in Non–Small Cell Lung Cancer
Authors: Ye Mingxiang , Zhang Yong , Zhang Xinxin , Zhang Jianbin , Jing Pengyu , Cao Liang , Li Nan , Li Xia , Yao Libo , Zhang Jian
Published: April 2023

This supplementary tables contain shRNAs, siRNAs, primers sequences and antibody resources.
Supplementary Tables 1 and 2 from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Authors: Baghdadi Muhammad , Wada Haruka , Nakanishi Sayaka , Abe Hirotake , Han Nanumi , Putra Wira Eka , Endo Daisuke , Watari Hidemichi , Sakuragi Noriaki , Hida Yasuhiro , Kaga Kichizo , Miyagi Yohei , Yokose Tomoyuki , Takano Atsushi , Daigo Yataro , Seino Ken-ichiro
Published: April 2023

Correlation between IL-34 and clinic-pathological characteristics, and Cox's proportional hazards model analysis of prognostic factors for OS in NSCLC patients
Fig. S5 from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Authors: Baghdadi Muhammad , Wada Haruka , Nakanishi Sayaka , Abe Hirotake , Han Nanumi , Putra Wira Eka , Endo Daisuke , Watari Hidemichi , Sakuragi Noriaki , Hida Yasuhiro , Kaga Kichizo , Miyagi Yohei , Yokose Tomoyuki , Takano Atsushi , Daigo Yataro , Seino Ken-ichiro
Published: April 2023

Decreased CD8 T cell activities and increased frequencies of Treg cells in IL-34-secreting chemoresistant tumors
Fig. S4 from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Authors: Baghdadi Muhammad , Wada Haruka , Nakanishi Sayaka , Abe Hirotake , Han Nanumi , Putra Wira Eka , Endo Daisuke , Watari Hidemichi , Sakuragi Noriaki , Hida Yasuhiro , Kaga Kichizo , Miyagi Yohei , Yokose Tomoyuki , Takano Atsushi , Daigo Yataro , Seino Ken-ichiro
Published: April 2023

IL-34 effects on transcriptional control of TAMs
Fig. S2 from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Authors: Baghdadi Muhammad , Wada Haruka , Nakanishi Sayaka , Abe Hirotake , Han Nanumi , Putra Wira Eka , Endo Daisuke , Watari Hidemichi , Sakuragi Noriaki , Hida Yasuhiro , Kaga Kichizo , Miyagi Yohei , Yokose Tomoyuki , Takano Atsushi , Daigo Yataro , Seino Ken-ichiro
Published: April 2023

IL-34 in the supernatant of chemoresistant lung cancer cells mediates its effects on monocytes differentiation
supplementary figure legend from TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade
Authors: Filipczak Piotr T. , Thomas Cindy , Chen Wenshu , Salzman Andrew , McDonald Jacob D. , Lin Yong , Belinsky Steven A.
Published: April 2023

supplementary figure legend
Supplementary Table S3 from The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem–like Properties in Glioblastoma That Contribute to Tumorigenesis
Authors: Ferreyra Solari Nazarena E. , Belforte Fiorella S. , Canedo Lucía , Videla-Richardson Guillermo A. , Espinosa Joaquín M. , Rossi Mario , Serna Eva , Riudavets Miguel A. , Martinetto Horacio , Sevlever Gustavo , Perez-Castro Carolina
Published: April 2023

shRNA target sequences, target region and construct number.
Fig. S2 from TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade
Authors: Filipczak Piotr T. , Thomas Cindy , Chen Wenshu , Salzman Andrew , McDonald Jacob D. , Lin Yong , Belinsky Steven A.
Published: April 2023

Cell death of TSC2-deficient cells requires mTOR activity but not induction of autophagy
Supplemental Figure S1 from The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem–like Properties in Glioblastoma That Contribute to Tumorigenesis
Authors: Ferreyra Solari Nazarena E. , Belforte Fiorella S. , Canedo Lucía , Videla-Richardson Guillermo A. , Espinosa Joaquín M. , Rossi Mario , Serna Eva , Riudavets Miguel A. , Martinetto Horacio , Sevlever Gustavo , Perez-Castro Carolina
Published: April 2023

Figure S1. INSECT analysis and KANSL2 expression in stem cells.
Supplementary Figures 1-7 from Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
Authors: Mittal Deepak , Sinha Debottam , Barkauskas Deborah , Young Arabella , Kalimutho Murugan , Stannard Kimberley , Caramia Franco , Haibe-Kains Benjamin , Stagg John , Khanna Kum Kum , Loi Sherene , Smyth Mark J.
Published: April 2023

Figures S1-S7 Supplementary Figure 1. A2BRi anti-metastatic activity does not require immune cells. Supplementary Figure 2. Mechanism of A2BRi. Supplementary Figure 3. Expression of adenosine receptors in tumor cells. Supplementary Figure 4. Effect of A2BR KD on primary tumor growth. Supplementary Figure 5. ADORA2B expression in human breast cancer. Supplementary Figure 6. A2BRi therapy of human breast cancer xenografts. Supplementary Figure 7. Effect of A2BR KD on cell viability.
Supplementary Table 3 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

List of mutations inserted in the simulated data set
Figure S1 from Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness
Authors: Hou Pei-Chi , Li Yo-Hua , Lin Shih-Chieh , Lin Shau-Chieh , Lee Jenq-Chang , Lin Bo-Wen , Liou Jing-Ping , Chang Jang-Yang , Kuo Ching-Chuan , Liu Yi-Min , Sun H. Sunny , Tsai Shaw-Jenq
Published: April 2023

Loss-of-DUSP2 results in the expansion of CSC-like population.
Table S4 from Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis
Authors: Maiuri Ashley R. , Peng Michael , Podicheti Ram , Sriramkumar Shruthi , Kamplain Caitlin M. , Rusch Douglas B. , DeStefano Shields Christina E. , Sears Cynthia L. , O'Hagan Heather M.
Published: April 2023

OTUs with significant differential abundance between the various groups and OTUs used in the heatmap in Figure 4B.
Supplemental Methods and Table S1 from Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis
Authors: Maiuri Ashley R. , Peng Michael , Podicheti Ram , Sriramkumar Shruthi , Kamplain Caitlin M. , Rusch Douglas B. , DeStefano Shields Christina E. , Sears Cynthia L. , O'Hagan Heather M.
Published: April 2023

Supplemental Methods for the MBD-seq analysis and Table S1, which provides primer sequences and assays used for Taqman and pyrosequencing.
Supplementary figures from Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter
Authors: Payen Valéry L. , Hsu Myriam Y. , Rädecke Kristin S. , Wyart Elisabeth , Vazeille Thibaut , Bouzin Caroline , Porporato Paolo E. , Sonveaux Pierre
Published: April 2023

Supplementary Figures provide additional evidence that MCT1 silencing decreases SiHa cell migration (Fig. S1), MCT1 silencing induces intracellular acidification in SiHa cancer cells (Fig. S2), Pharmacological MCT1 inhibition decreases lactic acid efflux in cancer cells (Fig. S3), MCT1 inhibition increases the oxidative metabolism of superinvasive SiHa-F3 cells (Fig. S4), MCT1 expression triggers NF-κB activity in SiHa cells (Fig. S5) and MCT1 silencing does not affect primary 4T1 tumor growth in mice (Fig. S6).
Figure S4 from SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance
Authors: Orlacchio Arturo , Ranieri Michela , Brave Martina , Arciuch Valeria Antico , Forde Toni , De Martino Daniela , Anderson Karen E. , Hawkins Phillip , Di Cristofano Antonio
Published: April 2023

Representative example of the limited effect of SGK1 depletion on the proliferation of a human BRAFV600E-driven thyroid cancer cell line, T235.
Supplementary Table 1 from Genomic Alterations in Circulating Tumor DNA from Diverse Cancer Patients Identified by Next-Generation Sequencing
Authors: Schwaederle Maria , Chattopadhyay Ranajoy , Kato Shumei , Fanta Paul T. , Banks Kimberly C. , Choi In Sil , Piccioni David E. , Ikeda Sadakatsu , Talasaz AmirAli , Lanman Richard B. , Bazhenova Lyudmila , Kurzrock Razelle
Published: April 2023

54 gene panel (ctDNA) identifies potential tumor-related genomic alterations within 54 cancer-related genes
Supplementary Figure 5 from ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA
Authors: Humphries Brock , Wang Zhishan , Li Yunfei , Jhan Jing-Ru , Jiang Yiguo , Yang Chengfeng
Published: April 2023

CRISPR/Cas9 knockout of ARHGAP18 reduces TNBC cell proliferation and migration
Figure S5 from LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response
Authors: Ha Ji Hee , Radhakrishnan Rangasudhagar , Jayaraman Muralidharan , Yan Mingda , Ward Jeremy D. , Fung Kar-Ming , Moxley Katherine , Sood Anil K. , Isidoro Ciro , Mukherjee Priyabrata , Song Yong Sang , Dhanasekaran Danny N.
Published: April 2023

Effect of silencing NOX1, NOX3, NOX4, and NOX5 on LPA-stimulated aerobic glycolysis
Figure S2 from LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response
Authors: Ha Ji Hee , Radhakrishnan Rangasudhagar , Jayaraman Muralidharan , Yan Mingda , Ward Jeremy D. , Fung Kar-Ming , Moxley Katherine , Sood Anil K. , Isidoro Ciro , Mukherjee Priyabrata , Song Yong Sang , Dhanasekaran Danny N.
Published: April 2023

LPA-induced aerobic glycolysis is mediated by Gαi2
Supplemental Materials from Integrating DNA Methylation and Hydroxymethylation Data with the Mint Pipeline
Authors: Cavalcante Raymond G. , Patil Snehal , Park Yongseok , Rozek Laura S. , Sartor Maureen A.
Published: April 2023

Supplementary Tables 1-3 and Supplementary Figures 1-5
Table S1-S3 from FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression
Authors: Hornsveld Marten , Smits Lydia M.M. , Meerlo Maaike , van Amersfoort Miranda , Groot Koerkamp Marian J.A. , van Leenen Dik , Kloet David E.A. , Holstege Frank C.P. , Derksen Patrick W.B. , Burgering Boudewijn M.T. , Dansen Tobias B.
Published: April 2023

Supplementary tables S1,S2 and S3 in separate tabs of an Excel file.
Supplementary Table 3 from Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L–AGRN Transcriptional Regulation Circuit
Authors: Li Xin , Wang Xianteng , Song Wanlu , Xu Hui , Huang Rongyao , Wang Yuting , Zhao Wenwei , Xiao Zhengtao , Yang Xuerui
Published: April 2023

Results of MINDy with PRAD data in TCGA.
Supplementary Table 1 from Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L–AGRN Transcriptional Regulation Circuit
Authors: Li Xin , Wang Xianteng , Song Wanlu , Xu Hui , Huang Rongyao , Wang Yuting , Zhao Wenwei , Xiao Zhengtao , Yang Xuerui
Published: April 2023

Differential expression data upon silencing of NEAT1 in PC3 cells.
Supplementary Figures and Index of Supplementary Tables from Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L–AGRN Transcriptional Regulation Circuit
Authors: Li Xin , Wang Xianteng , Song Wanlu , Xu Hui , Huang Rongyao , Wang Yuting , Zhao Wenwei , Xiao Zhengtao , Yang Xuerui
Published: April 2023

This file includes Supplementary Figures 1-7 and an index of Supplementary Tables 1-5. Supplementary Figure 1: Expression of NEAT1 isoforms and silencing efficiencies. Supplementary Figure 2: Volcano plot of gene differential expression results upon silencing of NEAT1 in PC3 cells. Supplementary Figure 3: Assessment of apoptosis in PC3 and DU145 cells upon silencing of NEAT1. Supplementary Figure 4: Analysis of cell cycle distribution with FACS. Supplementary Figure 5: Assessment of cell cycle upon silencing of NEAT1. Supplementary Figure 6: Silencing efficiencies of siRNAs. Supplementary Figure 7: Quantification of DNA damage and cell cycle upon silencing of AGRN. The Supplementary Tables are Supplementary Table 1: Differential expression data upon silencing of NEAT1 in PC3 cells, Supplementary Table 2: Results of functional enrichment analysis with differentially expressed genes upon silencing of NEAT1, Supplementary Table 3: Results of MINDy with PRAD data in TCGA, Supplementary Table 4: DNA binding regions identified by CDC5L ChIP-seq, Supplementary Table 5: Binding targets of CDC5L as identified by MACS.
Figure S6 from FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression
Authors: Hornsveld Marten , Smits Lydia M.M. , Meerlo Maaike , van Amersfoort Miranda , Groot Koerkamp Marian J.A. , van Leenen Dik , Kloet David E.A. , Holstege Frank C.P. , Derksen Patrick W.B. , Burgering Boudewijn M.T. , Dansen Tobias B.
Published: April 2023

FOXOs control PI3K signaling feedback in human cancer cells.
Supplementary Figure 4 from PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer
Authors: Cox Orla T. , Edmunds Shelley J. , Simon-Keller Katja , Li Bo , Moran Bruce , Buckley Niamh E. , Bustamante-Garrido Milan , Healy Nollaig , O'Flanagan Ciara H. , Gallagher William M. , Kennedy Richard D. , Bernards René , Caldas Carlos , Chin Suet-Feung , Marx Alexander , O'Connor Rosemary
Published: April 2023

Related to Figure 4: Includes TNBC subtype classification of the cell lines used in this study and additional analyses of expression of PDLIM2 and epithelial/mesenchymal markers. A graph illustrates PDLIM2 RNASeq and protein expression in the cell lines. Expression of b1 integrin, Phospho-EGFR, Phospho-IGF-1R and Phospho c-Met in TN Breast cell lines are also shown.