bluuebunny/crossref_metadata_2025 huggingface dataset:
High doses of minocycline may induce delayed activation of microglia in aged rats and thus cannot prevent postoperative cognitive dysfunction
Authors: Li Wenyao , Chai Qing , Zhang Hongwei , Ma Jing , Xu Chengfen , Dong Jifu , Wei Xianghua , Wang Zhiyi , Zhang Kexian
Published: February 2018

Objective

Postoperative cognitive dysfunction (POCD) is common after surgery in elderly patients and is associated with high morbidity. The molecular mechanisms responsible for POCD are unknown. Minocycline, an inhibitor of microglial activation, may be useful in treating and preventing POCD. We explored whether minocycline can inhibit microglial activation and prevent POCD in aged rats as a surgery model.

Methods

Rats aged 18 to 20 months were randomly allocated to the following groups: naïve, abdominal surgery alone, or minocycline injection before abdominal surgery. Hippocampal cytokine mRNA levels were measured at 3 hours, 1 day, 3 days, and 7 days after surgery, and microglial activation was measured at 3 hours and 7 days after surgery. Memory was assessed using the Morris water maze test.

Results

Surgery resulted in severe cognitive impairment in aged rats and induced a significant neuroinflammatory response and microglial activation. The use of minocycline can prevent microglial activation after surgery, but delayed microglial activation may occur. The use of minocycline may further impair memory after surgery.

Conclusion

Minocycline can restrain microglial activation and restrict the inflammatory response in the hippocampus early after surgery, but it may induce delayed microglial activation and cannot prevent POCD in aged rats.
Feminist legal archeology, domestic violence and the raced-gendered juridical boundaries of U.S. asylum law
Authors: Gorman Cynthia S
Published: February 2018

In 1996, a Guatemalan woman named Rody Alvarado was granted asylum in the United States but the decision was revoked three years later, triggering a controversy over border control, domestic violence and the standards of refugee protection. Through an intersectional, geographical and historical excavation of Alvarado’s case, I illustrate how adjudicators justified revoking asylum by initially framing her as a victim of unfortunate domestic abuse and then as a “scalar threat” to the spatial and legal order. By tracing the gendered and racialized discursive tactics and legal maneuvers deployed to prevent her from winning asylum, I demonstrate the raced, classed and gendered logics that structured legal decision-making and the pivotal role of intimate violence in processes of legal border control. Through a deep contextualization of Alvarado’s case, the paper advances critical and feminist geopolitical scholarship on the mutual constitution of the global and the intimate. In particular, I seek to advance feminist legal archeology as a methodology in political geography to make visible the discursive tactics and legal maneuvers involved in the struggle to delineate juridical and territorial borders, specifically as they relate to gender violence. I conclude by discussing how Alvarado’s case demonstrates the transcalar quality of the intimate in legal reasoning and the ways in which scale is differently constructed through the legal process to retain control over which bodies have access to political asylum.
Correctional Officers in Canada
Authors: Ricciardelli Rose , Power Nicole , Medeiros Daniella Simas
Published: February 2018

The potential for violence in prison shapes how correctional officers (COs) carry out their work. Yet, how provincial COs experience violence remains understudied. Using theoretical insights from the literature on workplace violence in caring and service occupations, we analyze observational data and interviews conducted with COs in eastern Canada. We show that COs carry out their everyday work under increasingly strained conditions (e.g., understaffing) and manage prisoners’ (sometimes violent) responses to deteriorating prison conditions (e.g., overcrowding) by engaging in emotional labor. The COs understand workplace violence as an inevitable “part of the job,” which serves to normalize the experience of workplace violence and deflect attention away from the prison conditions which exacerbate and even produce violence.
Property Crime Clearance in Small Jurisdictions
Authors: Roth Jeffrey J.
Published: February 2018

Research on the factors that influence crime clearance rates has primarily studied violent crimes in large cities. However, property crimes are among the most commonly occurring and least frequently cleared offenses, and the majority of police departments in the United States serve small jurisdictions. Thus, this study undertook an examination of the predictors of clearance rates for burglary, larceny, and vehicle theft in a sample of agencies serving populations of 50,000 people or fewer. Independent variables included both policing factors (e.g., workload, funding, broken windows arrests) and social disorganization indicators (e.g., residential instability, poverty). Negative binomial regression analyses revealed variation in the significance of the predictors across the three crimes. Additionally, many predictors found to be influential in prior work were insignificant in this study, which suggests differences in the nature of crime clearance between large cities and smaller jurisdictions and a need for further research in this area.
“It’s Almost Like Gay Sex Doesn’t Exist”: Parent-Child Sex Communication According to Gay, Bisexual, and Queer Male Adolescents
Authors: Flores Dalmacio , Docherty Sharron L. , Relf Michael V. , McKinney Ross E. , Barroso Julie V.
Published: February 2018

Sex communication interventions facilitate positive sexual health outcomes with heterosexual adolescents. The same has yet to be established for male youth with same-sex attractions, behaviors, and identities. Our study describes the experiences of gay, bisexual, and queer (GBQ)-identifying adolescent males with parent-child sex communication. We conducted 30 in-depth semistructured interviews with a diverse group of 15- to 20-year-old GBQ males. Interview transcripts were coded, and themes were identified using thematic and content analysis. Narratives revealed that sex communication with parents occurs rarely, is heteronormative in content prior to adolescent males’ disclosure as GBQ, and after disclosure is reactionary and based on stereotypes that associate this population with negative health outcomes. Parents were rated poorly as sex educators by adolescent males, and the findings are mixed regarding perception of parents’ knowledge about GBQ-specific information. Parents and health care providers were identified as preferred sources of sex information by GBQ adolescent males. Sex communication with parents throughout adolescence that excludes GBQ males’ same-sex concerns is a missed opportunity for targeted sexual risk reduction. There are multiple ways health care providers can assist parents to plan age-appropriate, sexuality-inclusive, home-based discussions about sex for this group.
The Impact of Implementing an Intensivist Model With Nighttime In-Hospital Nocturnist and Effect on ICU Outcomes
Authors: Tanios Maged A. , Teres Daniel , Park Hyunsoon , Beltran Antonio , Sehgal Arunpal , Leo James D.
Published: February 2018

Background:

Various intensivist staffing models have been suggested, but the long-term sustainability and outcomes vary and may not be sustained. We examined the impact of implementing a high-intensity intensivist coverage model with a nighttime in-house nocturnist (non-intensivist) and its effect on intensive care unit (ICU) outcomes.

Methods:

We obtained historical control baseline data from 2007 to 2011 and compared the same data from 2011 to 2015. The Acute Physiological and Chronic Health Evaluation outcomes system was utilized to collect clinical, physiological, and outcome data on all adult patients in the medical ICU and to provide severity-adjusted outcome predictions. The model consists of a mandatory in-house daytime intensivist service that leads multidisciplinary rounds, and an in-house nighttime coverage is provided by nocturnist (nonintensivists) with current procedural skills in airways management, vascular access, and commitment to supervise house staff as needed. The intensivist continues to be available remotely at nighttime for house staff and consultation with the nocturnist. A backup intensivist is available for surge management.

Results:

First year yielded improved throughput (2428 patients/year to 2627 then 2724 at fifth year). Case mix stable at 53.7 versus 55.2. The ICU length of stay decreased from 4.7 days (predicted 4.25 days) to 3.8 days (4.15) in first year; second year: 3.63 days (4.29 days); third year: 3.24 days (4.37), fourth year: 3.34 days (4.45), and fifth year: 3.61 days (4.42). Intensive care unit <24 hours readmission remained at 1%; >24 hours increased from 4% to 6%. Low-risk monitoring admissions remained at an average 17% (benchmark 17.18%). Intensive care unit mortality improved with standardized mortality ration averaging at 0.84. Resident satisfaction surveys improved.

Conclusions:

Implementing an intensivist service with nighttime nocturnist staffing in a high-intensity large teaching hospital is feasible and improved ICU outcomes in a sustained manner that persisted after the initial implementation phase. The model resulted in reduced and sustained observed-to-predicted length of ICU stay.
Exploring Reproductive Coercion in Relationship Contexts Among Young Adult, Primarily African American Women at Three Women’s Health Clinics
Authors: Paterno Mary T. , Draughon Moret Jessica E. , Paskausky Anna , Campbell Jacquelyn C.
Published: February 2018

Understanding reproductive coercion experiences in marginalized populations is important to assist in tailoring care and services. Reproductive coercion is consistently associated with intimate partner violence (IPV), engaging in sexual risk-taking, and is more commonly reported among non-White women. We conducted a secondary analysis of data from a mixed methods study to examine reproductive coercion in relationship contexts among a sample ( N = 130) of young adult, primarily African American women recruited from three women’s health clinics; 12 also participated in an in-depth interview. Thirty-six women (27.7%) reported reproductive coercion in the past year. Past-year reproductive coercion was associated with relationship trust, ( t(128) = −3.01, p = .003), and past-year IPV (Fisher’s exact test, p = .005). In the best-fit model, odds of past-year reproductive coercion increased by 4% with each one-point increase in relationship trust score (indicating reproductive coercion increased with lower trust; adjusted odds ratio [AOR] = 1.04; 95% confidence interval [CI] = [1.00, 1.08]), and by more than 4 times with past experience of IPV (AOR = 4.74; 95% CI = [1.07, 20.86]). Qualitative analysis revealed women’s awareness of reproductive coercion whether or not they personally experienced it. Those who experienced reproductive coercion identified it as a form of abuse and additionally described experiences of pressure to conceive from the partner’s family. Our results support routine screening for IPV and reproductive coercion. Furthermore, the intersection of partner reproductive coercion with family pressure related to reproductive decision making should be explored to better inform clinical interventions.
Maternal Perceptions of Infant Feeding and Health in the Context of the 2015 Nepal Earthquake
Authors: DeYoung Sarah , Suji Manoj , Southall Hannah G.
Published: February 2018

Background:

Displacement caused by the 2015 earthquake in Nepal exacerbated poor health and nutrition for thousands of women and children.

Research aim:

This study aimed to identify the perceptions of Nepalese mothers residing in earthquake relocation camps regarding barriers, facilitators, and situational factors influencing breastfeeding and family well-being.

Methods:

An exploratory, rapid ethnographic approach was used during two fieldwork phases. Phase 1 consisted of reconnaissance and observation, whereas Phase 2 consisted of observation and qualitative semistructured interviews with infant caretakers ( N = 14).

Results:

We found evidence of human milk substitutes donated by various groups after the earthquake, despite Nepal’s media statement condemning these donations. Participants in this study expressed concerns about their milk supply. They also expressed concerns about the impending winter season combined with distress about the 2015 fuel crisis and the impact that this had on their infants and children. Furthermore, participants expressed choices about infant feeding that were influenced by traditional Nepalese practices. Specifically, homemade complementary foods and spices designed to boost lactation were identified as being used during daily infant feeding practices.

Conclusion:

Infant caretakers need culturally specific support for breastfeeding after disasters. These findings can directly influence future interventions concerning Nepalese mothers’ perceptions, infant care, and feeding practices in disaster scenarios.
Energy absorption capability of laminated plates made of fully thermoplastic composite
Authors: Boria Simonetta , Scattina Alessandro
Published: February 2018

The behaviour of composites materials, made of synthetic fibres embedded in a thermoplastic resin, subjected to low velocity impacts, was largely studied in the past. However, in the last years, the use of thermoplastic composites has been increased due to the considerable advantages in terms of recyclability of this family of materials. Thermoplastic composites are composed of polymers with different material’s structure if compared to the more traditional thermoset composite. Consequently, the behaviour of these materials can be different in some loading conditions. Moreover, considering the wide range of thermoplastic composites that have been developed in the last years, the study of the behaviour of these materials, in case of impact, has not been yet widely analysed, in particular considering materials where both the matrix and the reinforcement are made of thermoplastic. In this perspective, the goal of this work is to study the behaviour of a new thermoplastic composite (PURE thermoplastic) in conditions of low velocity impact. In this material, the matrix and the fibre reinforcement are made of polypropylene both. The paper presents the results of an experimental investigation. In particular, a series of impact tests with a drop dart equipment have been carried out on laminates made of PURE thermoplastic. Laminates with different thicknesses have been taken into consideration. The influence of the impact conditions on the material’s behaviour has been investigated and the capability of energy absorption has been studied. The PURE thermoplastic showed a different behaviour in terms of energy absorption and damage mechanisms if compared to the composites presented in the literature. The thickness of the laminate has had influence on the deformation and the damage mechanism of the specimens: with low thickness, the perforation of the specimen has been obtained, whereas, with the higher thickness, the specimens have shown a ductile behaviour and extended plasticity without crack tip. The contact force between the dart and the specimen has been influenced by the energy level of the impact, but with an opposite trend if compared to that of the composites studied in the literature.
Systemic Lupus Erythematosus (SLE) Responder Index response is associated with global benefit for patients with SLE
Authors: Furie R , Wang L , Illei G , Drappa J
Published: February 2018

A post-hoc analysis of pooled data from two Phase IIb trials (sifalimumab; NCT01283139, anifrolumab; NCT01438489) assessed the clinical significance of a Systemic Lupus Erythematosus (SLE) Responder Index (SRI(4)) response (Week 52) for 736 patients with moderate to severe SLE disease activity (study entry). SRI(4) responders achieved significantly greater improvements in clinical outcome measures (including percentages of patients with a ≥ 7-point reduction in SLE Disease Activity Index (SLEDAI)–2000 (2K), British Isles Lupus Assessment Group “A” or “2B” flare rate, and oral corticosteroid reduction to ≤7.5 mg/day; change from baseline in Physician’s Global Assessment; and numbers of SLEDAI–2K organ domains with improvement), as well as in patient-reported outcomes (Patient’s Global Assessment, Functional Assessment of Chronic Illness Therapy−Fatigue; Short-Form 36 Health Survey Physical Component Summary, Mental Component Summary, Vitality domain scores) vs. nonresponders. Of patients with abnormal serologies, SRI(4) responders had numerically greater improvements (baseline to Week 52) in anti-double-stranded DNA concentrations vs. nonresponders ( p = 0.051), but there were no differences in C3/C4 concentration changes between the two groups. These results confirm previous findings in a different cohort, indicating that an SRI(4) response is associated with global clinical benefit.
Comparison between disease onset patterns of Egyptian juvenile and adult systemic lupus erythematosus (single centre experience)
Authors: Abdel-Nabi H H , Abdel-Noor R A
Published: February 2018

Background

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that occurs worldwide in both children and adults, with different disease manifestations, activity and severity between them.

Objectives

To analyse the difference in disease onset patterns and activity in Egyptian children and adults with SLE.

Methods

A retrospective cohort study conducted on 298 Egyptian SLE patients, 215 adults (a-SLE) (>18 years) and 83 children (j-SLE) (≤18 years). Disease onset, clinical manifestations and laboratory investigations were recorded. The systemic lupus erythematosus disease activity index (SLEDAI) was used to assess disease onset activity; renal biopsy was performed for all cases affected with renal symptoms.

Results

A total of 215 a-SLE (F/M: 14.4/1), mean age 29.65 ± 10.235 years, and 83 j-SLE (F/M: 5.4/1), mean age at diagnosis 12.63 ± 3.112 years. The most frequent initial a-SLE symptoms were constitutional (88.8%), mucocutaneous (71.2%), haematological (64.2%), articular (62.3%), renal (43.7%), vascular (15.3%), serositis (14.4%) and finally central nervous system (11.6%). There were no significant differences between a-SLE and j-SLE with regard to constitutional, mucocutaneous, renal, vascular and serositis manifestations, which were 92.8%, 74.7%, 53%, 16.9% and 10.8%, respectively, but the j-SLE haematological (88%) and central nervous system (30.1%) manifestations were significantly higher than a-SLE and articular manifestations were significantly lower in j-SLE (14.5%) than a-SLE. Antinuclear antibodies were positive for 95.3% of a-SLE and 97.6% of j-SLE. Anti-dsDNA was positive for 84.7% a-SLE and was significantly higher in j-SLE (92.8%). The SLEDAI score was 12.23 ± 4.966 in a-SLE and was significantly higher in j-SLE (27.13 ± 19.968). International Society of Nephrology lupus nephritis classes III and IV (42.4%) were the commonest findings in a-SLE; however, classes I and III (57.9%) were the commonest in j-SLE.

Conclusions

SLE had a wide variety of clinical and immunological manifestations, with some similarity and differences between a-SLE and j-SLE; juvenile onset lupus had a higher SLEDAI with more aggressive initial manifestations than a-SLE.
Anti-dsDNA titre in female systemic lupus erythematosus patients: relation to disease manifestations, damage and antiphospholipid antibodies
Authors: Gheita T A , Abaza N M , Hammam N , Mohamed A A A , El-Gazzar I I , Eissa A H
Published: February 2018

Background

Attempts are ongoing to unveil unresolved queries about anti-double-stranded deoxyribonucleic acid (anti-dsDNA), their precise pathogenic effects and to what extent blocking them would be a useful therapeutic goal.

Objectives

The aim of the present study was to determine the anti-dsDNA antibodies titre in systemic lupus erythematosus (SLE) patients and investigate their relation to the disease characteristics, activity, damage and antiphospholipid autoantibodies (aPL).

Methods

Seventy female SLE patients and 35 age- and sex-matched controls were included. The anti-dsDNA level and aPL were measured. Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI) were assessed.

Results

The mean age of the patients was 27.5 ± 5.1 years, disease duration 7.7 ± 5.4 years, and SLEDAI and SLICC/ACR-DI scores were 6.8 ± 8.04 and 1.2 ± 1.3, respectively. Anti-dsDNA was positive in 61.4% of the patients and the titre (133.2 ± 100.5 IU/ml) was significantly higher compared to controls (22.03 ± 17.2 IU/ml) ( p < 0.0001). The anti-dsDNA level was significantly increased in those with musculoskeletal manifestations ( p = 0.007) and positive anti-β2 glycoprotein (anti-β2GP) ( p = 0.037) and decreased in those with neuropsychiatric manifestations ( p = 0.004) and those receiving cyclophosphamide (CYC) ( p = 0.013). The anti-dsDNA level tended to be higher in active patients. The anti-dsDNA titre significantly correlated with the erythrocyte sedimentation rate ( p = 0.001), anticardiolipin IgG and IgA antibodies ( p = 0.008) and anti-β2GP IgG ( p = 0.03) and IgA ( p = 0.002) and inversely with the total leucocytic count ( p < 0.0001) and SLICC/ACR-DI ( p = 0.001).

Conclusion

Anti-dsDNA is remarkably increased in SLE patients especially those with musculoskeletal manifestations and aPL. A protective role seems likely in those with neuropsychiatric manifestations and those receiving CYC and may form a shield against disease tissue damage.
Thomas Secker M.D.: Archbishop and man-midwife
Authors: Morgan-Guy John
Published: February 2018

This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.
How to succeed with ethics reflection groups in community healthcare? Professionals’ perceptions
Authors: Karlsen Heidi , Lillemoen Lillian , Magelssen Morten , Førde Reidun , Pedersen Reidar , Gjerberg Elisabeth
Published: February 2018

Background:

Healthcare personnel in the municipal healthcare systems experience many ethical challenges in their everyday work. In Norway, 243 municipalities participated in a national ethics project, aimed to increase ethical competence in municipal healthcare services. In this study, we wanted to map out what participants in ethics reflection groups experienced as promoters or as barriers to successful reflection.

Objectives:

To examine what the staff experience as promoters or as barriers to successful ethics reflection.

Research design:

The study has a qualitative design, where 56 participants in municipal healthcare participated in 10 different focus-group interviews.

Ethical considerations:

The data collection was based on the participants’ informed consent and approved by the Data Protection Official of the Norwegian Centre for Research Data.

Results:

The informants had different experiences from ethics reflection group. Nevertheless, we found that there were several factors that were consistently mentioned: competence, facilitator’s role, ethics reflection groups organizing, and organizational support were all experienced as promoters and as a significant effect on ethics reflection groups. The absence of such factors would constitute important barriers to successful ethics reflection.

Discussion:

The results are coincident with other studies, and indicate some conditions that may increase the possibility to succeed with ethics reflection groups. A systematic approach seems to be important, the systematics of the actual reflections, but also in the organization of ethics reflection group at the workplace. Community healthcare is characterized by organizational instabilities as many vacancies, high workloads, and lack of predictability. This can be a hinder for ethics reflection group.

Conclusion:

Both internal and external factors seem to influence the organization of ethics reflection group. The municipalities’ instabilities challenging this work, and perceived as a clear inhibitor for the development. The participants experienced that the facilitator is the most important success factor for establishing, carrying out, and to succeed with ethics reflection groups.
“Life Goes On.” Everyday Tasks, Coping Self-Efficacy, and Independence: Exploring Older Adults’ Recovery From Hip Fracture
Authors: Langford Dolores , Edwards Nicola , Gray Samantha M. , Fleig Lena , Ashe Maureen C.
Published: February 2018

Older adults face many challenges in the first few months after hip fracture. Rehabilitation holds promise to assist the recovery process. Therefore, we used semistructured interviews to explore older adults’ and allied health professionals’ acceptance of a rehabilitation intervention for hip fracture, and we described perceptions of the early recovery period (<4 months). Interviews were recorded and transcribed verbatim; three authors independently read the transcripts multiple times and together developed themes guided by Interpretive Description. Older adults described the intervention as acceptable and provided valuable feedback for its future implementation. Older adults also provided reflections on their experience of fracture recovery. Themes that emerged included physical limitations and loss of independence, the long recovery time, and coping with additional complications of living with multimorbidity. To overcome challenges, older adults identified the need for social support and physical activity, balanced by their own personal outlook.
WITHDRAWN—Administrative Duplicate Publication: Voice Quality in Adults Treated for Unilateral Cleft Lip and Palate: Long-term Follow-up After 1- or 2-Stage Palate Repair
Authors: Morén Staffan , Lindestad Per Åke , Holmström Mats , Mani Maria
Published: February 2018

Morén, S., Lindestad, P. Å., Holmström, M., & Mani, M. (2018). Voice Quality in Adults Treated for Unilateral Cleft Lip and Palate: Long-term Follow-up After 1- or 2-Stage Palate Repair. The Cleft Palate-Craniofacial Journal, 55(5), 758–768. DOI: 10.1177/1055665618754946

Article withdrawn by publisher.

Due to an administrative error, this article was accidentally published in Volume 55 Issue 5 as well as Volume 55 Issue 8 of publishing year 2018 with different DOIs and different page numbers.

The incorrect version of the article with DOI: 10.1177/1055665618754946 has been replaced with this correction notice.

The correct and citable version of the article remains:

Morén, S., Lindestad, P. Å., Holmström, M., & Mani, M. (2018). Voice Quality in Adults Treated for Unilateral Cleft Lip and Palate: Long-Term Follow-Up After One- or Two-Stage Palate Repair. The Cleft Palate-Craniofacial Journal, 55(8), 1103–1114. DOI: 10.1177/1055665618764521
The Role of Ability in the Selection of Majors
Authors: Ludwikowski Wyndolyn M. A. , Armstrong Patrick I. , Redmond Bryan Vincent , Ridha Betool Bashir
Published: February 2018

The current study examined the extent to which ability provides incremental validity to the prediction of major choice beyond what is predicted by measures of personality, self-efficacy, and interests. College students at a large, Midwestern university completed the Ability Profiler after which they completed personality, self-efficacy, and interest measures. Through multinomial logistical regression analyses, ability was found to add some incremental validity (1.5% increase in variance explained), when combined with personality, interest, and self-efficacy measures, to the prediction of major choice. Interests and self-efficacy served as impactful predictors, with personality contributing some influence. This finding illustrates that career counselors should continue to assess clients’ interests and self-efficacy when helping them make career decisions. Additional research should be conducted to assess the utility of other ability measures in the career counseling process.
Biomechanical Evaluation of Suture Configurations in Lesser Toe Plantar Plate Repairs
Authors: Finney Fred T. , Lee Simon , Scott Jaron , Irwin Todd A. , Holmes James R. , Talusan Paul G.
Published: February 2018

Background:

Lesser toe metatarsal-phalangeal (MTP) joint instability can be a major source of pain and dysfunction. Instability occurs when there is incompetence of the plantar plate and/or collateral ligaments. Newer operative treatments focus on performing anatomic repairs of the plantar plate. The goal of this study was to compare the biomechanical properties of 3 suture configurations that may be used for plantar plate repairs.

Methods:

Biomechanical analysis of 27 lesser toe plantar plates from fresh frozen human cadavers was completed. The plantar plate was detached from the proximal phalanx, and suture was placed in the distal plantar plate in a horizontal mattress, luggage-tag, or Mason-Allen suture configuration. Cyclic loading followed by load-to-failure testing was performed.

Results:

There was a significant difference in peak load-to-failure force between constructs (mattress: 115.53 ± 15.95 N; luggage-tag 102.42 ± 19.33 N; Mason-Allen: 89.96 ± 15.78 N; P = .015). Post hoc analysis demonstrated that the mattress configuration had significantly higher load-to-failure force compared with the Mason-Allen configuration ( P = .004). There were no significant differences between the mattress and the luggage-tag configurations or the luggage-tag and the Mason-Allen configurations. There were no differences in construct stiffness, axial displacement at the time of failure, or number of cycles required to produce 2 mm of displacement.

Conclusion:

The mattress configuration demonstrated better peak load-to-failure force compared with the Mason-Allen configuration but was not statistically different from the luggage-tag configuration. Although not significant, the mattress configuration trended toward higher load-to-failure force compared with the luggage-tag.

Clinical Relevance:

The horizontal mattress stitch may be the biomechanically superior configuration in plantar plate repairs.
Optimum SHEPWM for a new 21-level inverter topology using numerical optimization methods: experimental comparative study
Authors: Chabni Fayçal , Taleb Rachid , Helaimi M’hamed
Published: February 2018

This article presents the application of the harmony search (HS) optimization algorithm for harmonic elimination in a new topology of multilevel inverters with a reduced number of electronic switching elements. The main objective of the harmonic elimination strategy is eliminating undesired low rank harmonics in order to improve the quality of the output waveform. The harmonic elimination strategy is achieved by solving a system of nonlinear equations. In this paper, HS optimization is applied using artificial neural networks (ANNs) on a new 21-level inverter topology. The algorithm is based on the music improvisation process. MATLAB programming software was used to develop a HS optimization program for harmonic elimination. The main reason for using selective harmonic elimination based on ANNs in this study is to control the proposed multilevel inverter in real-time. In order to assess the performance of the proposed optimization method, it was compared to particle swarm optimization and the genetic algorithm. A small-scale laboratory of the proposed 21-level inverter is built to validate the simulation results and to prove the efficiency of the proposed control scheme.
A single center retrospective cohort study comparing low-molecular-weight heparins to direct oral anticoagulants for the treatment of venous thromboembolism in patients with cancer – A real world experience
Authors: Phelps Megan K , Wiczer Tracy E , Erdeljac H Paige , Van Deusen Kelsey R , Porter Kyle , Philips Gary , Wang Tzu-Fei
Published: February 2018

Introduction

Low-molecular-weight heparins are the standard treatment for cancer-associated thrombosis. Recently, direct oral anticoagulants are a new option for thrombosis treatment; however, data supporting the use of direct oral anticoagulants for cancer-associated thrombosis are limited.

Objectives

The primary objective of this study was to determine the rate of recurrent cancer-associated thrombosis and major bleeding within 6 months of starting either low-molecular-weight heparin or direct oral anticoagulant for treatment of cancer-associated thrombosis. Secondary objectives were to determine the rates of clinically relevant-non-major bleeding and all-cause mortality.

Patients/methods

This is a retrospective cohort study including adults with cancer-associated thrombosis treated with low-molecular-weight heparin or direct oral anticoagulant between 2010 and 2016 at the Ohio State University. Medical records were reviewed for 6 months after initiation of anticoagulation or until the occurrence of recurrent cancer-associated thrombosis, major bleeding, cessation of anticoagulation of interest, or death, whichever occurred first.

Results

Four hundred and eighty patients were included (290 low-molecular-weight heparin and 190 direct oral anticoagulant). Patients treated with direct oral anticoagulant were found to carry “lower risk” features including cancer with lower VTE risk and lower rate of metastatic disease. After adjustment for baseline differences, there was no significant difference in the rate of recurrent cancer-associated thrombosis (7.2% low-molecular-weight heparin vs 6.3% direct oral anticoagulant, p = 0.71) or major bleeding (7.6% low-molecular-weight heparin vs 2.6% direct oral anticoagulant, p = 0.08).

Conclusions

Our study demonstrates that in a select population of cancer patients with VTE, direct oral anticoagulant use can be as effective and safe compared to the standard therapy with low-molecular-weight heparin.
Using a treatment diary to improve the medication adherence in patients with chronic myeloid leukaemia
Authors: Santoleri Fiorenzo , Lasala Ruggero , Logreco Andrea , Ranucci Elena , Costantini Alberto
Published: February 2018

Purpose

The aim of this study was to verify whether the distribution of a treatment diary by a pharmacist could influence the adherence to oral treatment with imatinib, nilotinib, and dasatinib in patients with chronic myeloid leukaemia.

Methods

The level of adherence was calculated using the received daily dose/prescribed daily dose ratio and compared between patients who used a diary and those who did not.

Results

Forty-four (35.8%) of 123 patients with chronic myeloid leukaemia completed the diary: 20 (45.4%) receiving imatinib, 17 (38.6%) receiving nilotinib, and seven (15.9%) receiving dasatinib. Treatment adherence with the diary calculated using received daily dose/prescribed daily dose method was 93.6% (imatinib 94.9%, nilotinib 91.1%, and dasatinib 95.8%). Adherence during the period without a diary was 86.5% (84.9, 87.4, and 90%). Adherence was significantly greater with than without a diary (p < 0.0001).

Conclusions

The findings of this study that, in the case of chronic diseases, direct pharmacist–patient contact is important in order to maintain high levels of adherence, and a treatment diary is a valid means of doing this. According to these data, it is necessary to support similar patient-oriented programmes in order to ensure high levels of adherence and optimize drug management.
The Social Construction of Warranting Evidence in Two Classrooms
Authors: Weyand Larkin , Goff Brent , Newell George
Published: February 2018

This study examines how instructional conversations revealed the ways two teachers’ argumentative epistemologies (ideational and social process) shaped literacy events focused on the warranting of evidence. A microethnographic study of the literacy events within each teacher’s respective instructional unit revealed that each teacher’s epistemology shaped how students were asked to consider differing sources, relevancy, and sufficiency for warranting evidence within the context of writing extended argumentative essays. Events within an ideational epistemology required students to generate warrants as ideas to be applied to arguments in on-demand writing situations. Within a social process epistemology, students constructed warrants as a social practice appropriate for a specific rhetorical context. Each teacher supported his or her students in developing differing understandings of the nature of warranting. These findings highlight the importance of analyzing the teaching and learning of argumentative writing not only as written products of instruction but as a socialization into argumentative writing practices.
Learning Music Literacies Across Transnational School Settings
Authors: Skerrett Allison
Published: February 2018

This article examines an adolescent’s music literacy education across Caribbean and U.S. schools using qualitative research methods and theories of multimodality, transnationalism, and global cultural flows. Findings include that the youth’s music literacy practices continuously shifted in response to the cultural practices and values of the physical geographies in which he alternatively lived; however, transnational movements combined with extended physical sojourning contributed to the youth’s development of progressively generative perspectives about the potential of U.S. contexts for building his music literacies and a correspondent constraining view on Caribbean geographies for his music literacy development. Amid an abundance of research on the significance of online worlds to transnational youths’ identity and literacy development, this article contributes insights into how formal literacy education physically experienced within and across nations shapes the nature of literacy learning.
Contemplating and Extending the Scholarship on Children’s and Young Adult Literature
Authors: Brooks Wanda , Cueto Desiree
Published: February 2018

To commemorate the 50th anniversary of the Journal of Literacy Research, this article reviews the trajectory of a particular line of scholarship published in this journal over the past five decades. We focus on African diaspora youth literature to contemplate and extend the ways in which literacy researchers carry out textual analysis research of diverse children’s and young adult literature. We situate this line of scholarship (and its trajectory) within the broader literacy field and then narrow to a focus on diverse books. Next, to turn our gaze as literacy researchers forward to the future, we present our own critical content analysis of a young adult text collection. Our analysis incorporates postcolonial theory and a youth lens to interrogate how underlying ideologies identified within the novels support, refute, or reconstruct dominant beliefs about Black girls. We end with a set of implications for researchers interested in theorizing about or further investigating diverse children’s or young adult literature.
The Effect of Prevailing Wage Repeals on Construction Income and Benefits
Authors: Fenn Ari , Li Zhi , Pleites Gabriel , Zorigtbaatar Chimedlkham , Philips Peter
Published: February 2018

While considerable research has examined the effects of prevailing wage law repeals on construction wages, little has been done on the repeals effect on benefits. Based on state-level data from the quinquennial Economic Census for construction from 1972 to 2012, we find that depending on sample and model specification, statewide annual average construction blue-collar income fell by 1.9% to 4.2%. Statewide annual average legally required benefits (social security, workers injury-compensation insurance, and unemployment insurance contributions) for blue- and white-collar construction employees combined fell from 3.8% to 10.1%. Statewide annual average voluntary benefits (primarily health insurance, pension contributions, and apprenticeship training) for blue- and white-collar construction employees combined fell from 11.2% to 16.0%. Because prevailing wage laws govern only blue-collar construction remuneration, blue-collar benefits probably fell more than blue- and white-collar benefits taken together.
SWPhylo – A Novel Tool for Phylogenomic Inferences by Comparison of Oligonucleotide Patterns and Integration of Genome-Based and Gene-Based Phylogenetic Trees
Authors: Yu Xiaoyu , Reva Oleg N
Published: February 2018

Modern phylogenetic studies may benefit from the analysis of complete genome sequences of various microorganisms. Evolutionary inferences based on genome-scale analysis are believed to be more accurate than the gene-based alternative. However, the computational complexity of current phylogenomic procedures, inappropriateness of standard phylogenetic tools to process genome-wide data, and lack of reliable substitution models which correlates with alignment-free phylogenomic approaches deter microbiologists from using these opportunities. For example, the super-matrix and super-tree approaches of phylogenomics use multiple integrated genomic loci or individual gene-based trees to infer an overall consensus tree. However, these approaches potentially multiply errors of gene annotation and sequence alignment not mentioning the computational complexity and laboriousness of the methods. In this article, we demonstrate that the annotation- and alignment-free comparison of genome-wide tetranucleotide frequencies, termed oligonucleotide usage patterns (OUPs), allowed a fast and reliable inference of phylogenetic trees. These were congruent to the corresponding whole genome super-matrix trees in terms of tree topology when compared with other known approaches including 16S ribosomal RNA and GyrA protein sequence comparison, complete genome-based MAUVE, and CVTree methods. A Web-based program to perform the alignment-free OUP-based phylogenomic inferences was implemented at http://swphylo.bi.up.ac.za/ . Applicability of the tool was tested on different taxa from subspecies to intergeneric levels. Distinguishing between closely related taxonomic units may be enforced by providing the program with alignments of marker protein sequences, eg, GyrA.
Hemostasis After Brachial Artery Access With the MynxGrip Device: A Case Report
Authors: Giordano Arturo , Messina Stefano , Maresca Gennaro , Biondi-Zoccai Giuseppe
Published: February 2018

Purpose:

Brachial access is occasionally used for endovascular procedures when other more established or safer ones (eg, femoral or radial) are contraindicated. Although manual compression is the standard of care after brachial arteriotomy, suboptimal compression may lead to bleeding or thrombosis. Arteriotomy closure devices have thus been proposed as an alternative means to achieve hemostasis after brachial arteriotomy. Yet, there is a paucity of evidence and a limited spectrum of devices suitable for brachial arteriotomy closure. We present the use of the MynxGrip closure device after brachial arteriotomy.

Case:

A 70-year-old gentleman underwent brachial arteriotomy followed by iliac artery stenting with a 7F compatible device. Hemostasis was then achieved with the MynxGrip device, uneventfully.

Conclusions:

This clinical vignette highlights the feasibility and safety of brachial use of the MynxGrip device in experienced hands, suggesting that it can represent a useful adjunct to the armamentarium of the endovascular specialist.
On the Diagnosis of Mycotic Aortic Aneurysms
Authors: Sörelius Karl , di Summa Pietro G
Published: February 2018

Objective:

There is striking paucity in consensus on the terminology, definition, and diagnostic criteria of mycotic aortic aneurysms. This literature study aims to elucidate this scientific omission, discuss its consequences, and present a proposition for reporting items on this disease.

Methods:

A systematic literature review on PubMed and Medline using mycotic and infected aortic aneurysms between 1850 and 2017 was performed. Articles were assessed according to a protocol regarding terminology, definition, and diagnostic criteria. Case series with less than 5 patients were excluded.

Results:

A total of 49 articles were included. The most prevalent term was mycotic aortic aneurysm but there was no widely accepted definition. Most modern publications used a diagnostic workup based on a combination on clinical presentation, laboratory results, imaging findings, and intraoperative findings. How these protean variables should be balanced was unclear. A proposition of reporting items was framed and consisted of definition of disease used, basis of diagnostic workup, exclusion criteria, patient characteristics, laboratory and imaging findings, aneurysm anatomy, details on treatment, pre/postoperative antibiotic treatment, and details on follow-up.

Conclusions:

This article emphasizes the need to standardize definition, terminology, and diagnostic criteria for mycotic aortic aneurysms and proposes reporting items enhancing comparability between studies.
Orbital Inflammatory Complications of Crohn’s Disease: A Rare Case Series
Authors: Monaghan Tanya M , Albanese Giorgio , Kaye Philip , Thomas James D , Abercrombie Lorraine C , Moran Gordon W
Published: February 2018

Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn’s disease. Inflammation is characteristically nonspecific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly understood. The aim of this report is to present 3 cases of orbital involvement in Crohn’s disease. A retrospective case note review of patients with orbital inflammatory disease and Crohn’s disease was performed at our academic center to determine the clinical, imaging, and histopathologic features of this condition and its relationship to intestinal Crohn’s disease. Three patients were identified with orbital inflammatory manifestations complicating Crohn’s disease. All patients described were women with active intestinal disease and had a history of treatment with immunosuppressive therapies. Similarities were observed in clinical presentations with variance noted in radiologic and histopathologic findings. In all cases, symptoms improved with oral corticosteroids or nonsteroidal drugs in combination with anti-tumor necrosis factor agents. Inflammatory bowel disease–related orbital complications are rare but potentially vision-threatening. It is important to consider mimics of orbital inflammatory disease such as systemic inflammatory disease, malignancy, congenital malformations, infection, and trauma when formulating a comprehensive differential diagnosis. Therapeutic intervention is directed toward preservation of vision and orbital function and reducing the acute inflammatory process. Corticosteroids are typically the initial treatment of choice for moderate-to-severe disease, although several classes of immunomodulatory agents have been variably useful in treating this condition. Heightened awareness and close cooperation between gastroenterologists and ophthalmologists are mandatory.
Measurement of peripheral blood flow in patients with peripheral artery disease: Methods and considerations
Authors: Salisbury Dereck L , Brown Rebecca JL , Bronas Ulf G , Kirk Laura N , Treat-Jacobson Diane
Published: February 2018

Peripheral artery disease (PAD) is a manifestation of generalized atherosclerosis which results in hemodynamic compromise of oxygen and substrate delivery to the lower extremity skeletal muscles. Hemodynamic assessments are vital in PAD diagnosis and in the evaluation of strategies aimed at treating claudication (i.e. exercise training, revascularization, and pharmacological agents). Venous occlusion plethysmography (VOP) is a century-old, non-invasive technique used to quantify limb blood flow and has been used to evaluate hemodynamic compromise in patients with PAD. However, the literature suggests a wide array of methodological variability in the measurement and analysis of limb blood flow using VOP. In this manuscript, we overview the clinical application of VOP measurement, and secondly we review the methodological variation that occurs during the measurement and analysis of VOP in healthy individuals and in patients with claudication.