bluuebunny/crossref_metadata_2025 huggingface dataset:
Responses of the Brazilian health system to the emergency of the Zika virus: different strategies adopted by the states of Ceará and Rio de Janeiro
Authors: Albuquerque Mariana Vercesi de , Pepe Vera Lucia Edais , Reis Lenice Gnocchi da Costa , Oliveira Catia Veronica dos Santos , Cunha Aline de Araujo Gonçalves da , Dias Henrique
Published: May 2024

Abstract The article analyzes the cases of health system reprogramming in response to the Zika emergency in the states of Ceará (CE) and Rio de Janeiro (RJ), from 2015 to 2017. The research was anchored in the historical and institutionalist approach and the literature on regionalization and health care networks. It involved analyzing government documents and conducting interviews with key actors mobilized in the states’ response to the epidemic. For each state, the following aspects were primarily explored: context, political-financial situation and health agenda at the time of the epidemic; and the design and implementation of responses (meanings, actors, resources, strategies and repercussions). The reprogramming of the health system in the states of CE and RJ presented different conditions and different meanings of actions, strategies, mobilized actors and developments, with a focus on care initiatives for children with Congenital Zika Virus Syndrome (SCZV). The importance of the regionalized and coordinated network was highlighted, with deconcentration of the offer of specialized services and early stimulation procedures; the coordinating and investing role of the state government; the qualification initiatives of health professionals; of the performance of research institutions in the service, production of knowledge and in the dialogue with affected families.
The end of unfinished health emergencies and the Congenital Zika Syndrome
Authors: Scott Russell Parry
Published: May 2024

Abstract Understanding health problems as always unfinished, this article examines consequences of the declaration of the end of a health emergency on the practice of different and interconnected care networks. As part of the “Action Ethnography on Care…” research project, this is a qualitative case study of three documents produced after the announcement of the end of the Congenital Zika Virus Syndrome epidemic. It shows the contexts of narrative production involving researchers, managers/ public service workers, mothers and families of the ill, and mothers’ associations and their different perspectives about what care is. Analyses of a presentation for researchers and of a working paper for the Applied Economics Research Institute (IPEA) question the technical narrative celebrating the end of the emergency based on knowledge and health service without taking into account the relational, affective and political care (of mothers, families and associations), leaving the latter invisible. It describes the process of elaboration of a motion by the Zika Pandemic Forum, listing and systematizing action proposals produced in an explicit dialogue among participants in different care networks to approach unfinished post-emergency questions. It suggests that similar practices of dialogue between networks can promote greater inclusion and sensitivity to care that contribute to reducing suffering and defending the rights of people who continue to live daily with a syndrome or disease whose consequences persist.
Zika virus in Northeast Brazil: retrospective for research
Authors: Oliveira Ellen Hilda Souza de Alcantara , Campos Daniel de Souza , Moreira Martha Cristina Nunes , Nascimento Marcos Antonio Ferreira do , Peiter Paulo Cesar
Published: May 2024

Abstract O artigo trata das impressões compartilhadas de pesquisadores e sua experiência no trabalho de campo no Nordeste do Brasil, no âmbito do projeto Promoção da saúde no contexto da epidemia de zika: atores e cenários nos processos de tomada de decisão (FIOCRUZ/ZIKAlliance). Aqui procuramos compartilhar impressões de campo sobre uma pesquisa acerca da epidemia de Zika vírus, em dois municípios situados em diferentes localidades do Nordeste. Evidenciamos a importância do caderno de campo na pesquisa qualitativa e tecemos reflexões acerca dos resultados das entrevistas realizadas com mulheres em idade reprodutiva, gestantes, profissionais de saúde, mães e pais de crianças acometidas por microcefalia e trabalhadores autônomos. A partir dos depoimentos, foi possível observar aproximações, identificações e estranhamentos dos sujeitos de pesquisa com os pesquisadores, constituindo importante termômetro para nossa percepção do campo e das possibilidades de produção de conhecimento científico sobre a epidemia do Zika no Nordeste do Brasil.Abstract: This article deals with the shared impressions of researchers and their experience in fieldwork in Northeast Brazil, within the project's scope: Health promotion in the context of the Zika epidemic: actors and scenarios in decision-making processes (FIOCRUZ/ZIKAlliance). Here, we seek to share field impressions of research on the Zika Virus in two municipalities located in different locations in the Northeast. We highlight the importance of the field notebook in qualitative research and reflect on the results of interviews conducted with women of reproductive age, pregnant women, health professionals, mothers and fathers of children affected by microcephaly, and self-employed workers. From the testimonies, it was possible to observe similarities, identifications, and estrangements between the research subjects and the researchers, constituting a vital thermometer for our perception of the field and the possibilities of producing scientific knowledge about the Zika epidemic in Northeastern Brazil.
Stewarding Collections in Times of Changing Perspectives
Authors: Pantalony Rina
Published: May 2024

Libraries, archives, museums and other cultural heritage organizations are collections-based institutions with the mission to preserve their collections and make them accessible in various ways, whether for research, study, exhibition and educational purposes, while holding the physical collections in trust for the public. With the transitioning values for the collecting practices, the norms of collecting practices and accessibility standards are being challenged. The provenance of collections is being challenged, as well, and in some cases, objects and materials in collections have become the subject of repatriation. This is particularly true where collections include objects and materials that were acquired or taken from one global region or community and accessioned into the collection of a cultural heritage organization in another. How can access to collections be provided to patrons and the public in a way that is true and respectful of the normative traditions of traditional communities, in keeping with shifting societal values? This article presents the argument that a recognition and respect for intellectual property norms, specifically traditional knowledge (TK) and traditional cultural expressions (TCEs), facilitates quality collections stewardship and access to collections.
Exploring types of parent attachment via the clustering modules of a new free statistical software, ROP-R
Authors: Vargha András , Grezsa Ferenc
Published: May 2024

The aim of the paper is threefold: (1) to demonstrate the rich repertoire of clustering capabilities of a ROPstat and R-based new and free software, called ROP-R, by illustrating several analyses with real psychological data; (2) to show how well ROP-R works in tandem with ROPstat software in complex classification analyses; and (3) to explore some nontrivial types of parent attachment using the clustering modules of ROP-R. Four modules of ROP-R are available for performing cluster analyses (CAs), with several methods (e.g., divisive hierarchical CA, k-medoids CA, k-medians CA, model-based CA) not found in other user-friendly menu-driven software. In the paper, mother and father attachment data are used from a study with adolescents (Mirnics et al., 2021) to illustrate how the ROP-R software can be used to perform various CAs and evaluate the results using attractive graphs and useful tables. Comparing different clustering methods, it was found that both standard AHCA and k-means CA could discover a 7-type structure, which was also verified by the nonstandard k-medians CA. However, the nonstandard k-medoids CA and MBCA methods were not very effective in identifying a structure with an acceptable overall homogeneity. Nevertheless, they were able to identify some types through extremely homogeneous clusters.
The role of laboratory diagnostics in the assessment of occupational lead exposure
Authors: Ibišević Amela , Papić Emsel , Čano Dedić Lejla , Šečić Sabina , Šegalo Sabina
Published: May 2024

Introduction: Industrialization and urbanization led to a significant increase in the environment. Lead inhibits the activity of numerous enzymes, triggers oxidative stress, and causes protein biosynthesis dysregulation. Inhalation of lead particles is the most common route of intoxication associated with occupational exposure. This study aims to evaluate laboratory methods and biomarkers in the assessment of lead exposure.
Methods: For non-experimental qualitative research, available scientific articles in English published in the relevant databases (MEDLINE and ScienceDirect) were used. The database search was performed using the keywords “Laboratory diagnostics”, “occupational exposure”, and “lead”.
Results: Atomic absorption spectrometry (AAS) is the gold standard in laboratory monitoring of occupational lead exposure. Inductively coupled plasma with mass spectrometry is a commonly used method described as more sensitive than AAS due to its low detection limit. Lead concentrations can be determined in various samples, but blood and urine are the most commonly used in laboratory practice. The most important exposure biomarker is the enzyme δ-aminolevulinic acid dehydratase (ALAD) in the blood, which is characterized by progressive inactivation by lead and a negative correlation with its concentration. The concentration of urinary delta-aminolevulinic acid (δ-ALA-U) reflects the state of impaired enzyme function in heme biosynthesis. In addition, determining blood zinc protoporphyrin and urinary coproporphyrin levels significantly aids in assessing occupational lead exposure disorders.
Conclusion: The availability of the laboratory methods used and the biomarker specificity and sensitivity play an important role in the adequacy of lead exposure monitoring. Accurate determination of ALAD and δ-ALA-U concentrations, along with other biomarkers, is critical for assessing individuals exposed to lead.
Efficiency of dry needling along with standard physical treatment in people with lumbar pain syndrome
Authors: Džaferović Demir , Katana Bakir , Bojičić Samir , Mačak Hadžiomerović Amra , Jaganjac Amila , Trtak Namik , Kaljić Eldad
Published: May 2024

Introduction: The complaints that occur in the area of the lumbar spine are summarized under the term lumbar pain syndrome. These include lumbar discopathy, lumbago, lumboischialgia, sciatica, and other complaints associated with the lumbar region of the spine. The purpose of this study is to evaluate sociodemographic characteristics, assess the degree of disability patients experience due to lumbar pain syndrome, evaluate how many patients catastrophize their pain, and assess the effectiveness of the dry needling technique along with other physical therapy modalities in people with lumbar pain syndrome.
Methods: The study was designed as a prospective study conducted from March 2022 to June 2022. 35 subjects of both sexes, aged 25-83, agreed to participate in the study. The subjects who enrolled were pre-dominantly suffering from chronic lumbar pain syndrome, and there were also a smaller number of subjects with acute lumbar pain syndrome.
Results: The majority of respondents suffer from lumbar pain syndrome, which falls into the chronic category in 29 or 82.9% of cases. The mean score after the application of therapy on the Oswestry Disability Index (ODI) scale was 22.0 ± 16.23% and was statistically significantly lower. The average score after the application of the therapy on the visual analog scale (VAS) was 3.06 ± 2.31 and is statistically significantly lower (p < 0.05) compared to the period before the therapy.
Conclusion: Dry needling in combination with standard physical procedures led to statistically significant improvements. The mean score on the pain catastrophe scale, VAS, and ODI was significantly lower than in the pre-therapy period.
Pre-Service Teacher Mentors’ Perceptions Regarding Their Role and Preparation for Mentoring in Chile
Authors:   Universidad Bernardo O'Higgins, Tabali Pia , Monasterio Diego ,   Universidad Bernardo O'Higgins
Published: May 2024

The study of pedagogical internships has gained greater importance over the last decades around the world. In Chile, many researchers have been attempting to delve deeper into this reality; however, little is known about the experiences of preservice teacher mentors when tutoring pre-service teachers of English pedagogy. Following the qualitative paradigm, this exploratory descriptive study aims to investigate the perspectives and expectations of pre-service teacher mentors’ regarding their key roles as mentors in initial training. Seven English teachers with experience as mentor teachers were interviewed. One group interview and four individual interviews were conducted with English teachers working with preservice teachers in their practicums. Thematic analysis was employed to analyze the data. Issues related to the multiple roles of mentor teachers were discussed, as well as the relationship they construct with their students, the university, and the school where practicums are carried out. The main findings of this study suggest that pre-service teacher mentors expected clear guidelines from universities and the government to better guide future teachers. Moreover, they expected to be more involved in training pre-service teachers to contribute to their classrooms. Implications shed light on the need for incorporating the voices of pre-service teachers’ mentors in future research studies concerning pedagogical practicums in elt in Chile.
Ultraclean coal production using froth flotation and acid leaching
Authors: Barraza Juan , Mejía Isabel
Published: May 2024

Ultraclean coals represent an important raw material to elaborate high value products such as carbon fiber, electrodes, carbon foam and so on. In this work, ultraclean coals having less than 0.50% (w/w, db) of ash and 1.00% q(w/w) of mineral matter were obtained using flotation column and leaching with acid fluorhídric (HF) and nítric (HNO3 ). Ash content was reduced from 19.60 to 8.70 %, using three flotation stages. Chemical processing, using HF 7.53 M and HNO3 2.30 M, produced 1.42% of ash content, 0.86 % of sulphur and 2.00% of mineral matter, whereas a combined process, froth flotation followed by leaching of HF 19.2M and HNO3 8.12M produced a coal having 0.48 % of ash content, 0.71% of sulphur content and 0.96% of mineral matter. However, when it was used the original coal (unfloated) at the same acid conditions of the combined process, it was obtained an ultraclean coal having 0.33% of ash content.
Models of steel mass loss by atmospheric corrosion in Colombia using
Authors: Velilla Esteban , Villada Fernando , Echeverría Félix
Published: May 2024

In order to classify the corrosivity of the different Colombian atmospheres, as part of an extensive research project [1], plates of carbon steel were placed in 21 stations spread along the country electrical infrastructure (transmission lines and substations). There were measured among others at these stations, the time of wetness and deposition of sulfates and chlorides for 12 months, in addition steel plates were taken bimonthly to the laboratory in order to measure the mass loss suffered by these during the time of exposure. The classification of the 21 stations was done in 4 groups, considering the time of moisture, content of chlorides and sulfates, height above sea level and the plates exposure time; these are considered linearly independent variables according to the implemented technique of decomposition unique values (DPS). The criterion used for classification was the similarity of the variables using the Euclidean rule considered in the Kohonen unsupervised neural network. Additionally, models were implemented for the steel mass loss for each one of the groups using feed forward neural networks (RN), defining the above variables as inputs and the mass loss as the output. Besides, the comparison between the RN model for the group 1, with other models using genetic algorithms (GA) and the Simplex method is presented.
Particulate matter concentrations at public schools located near major urban roads in Bogota, Colombia: a pilot study
Authors: Franco Juan Felipe , Rojas Néstor Yesid , Sarmiento Olga Lucía , Hernández Luis Jorge , Zapata Elizabeth , Maldonado Andrea , Matiz Leonardo , Behrent Eduardo
Published: May 2024

A pilot study, in which we conducted inhalable particulate matter (PM10) measurements in four public elementary schools in Bogotá, is presented. Three of these schools are located alongside major urban roads with different types of public transportation. The remainder school is located alongside a rural road. PM10 measurements were carried out using both gravimetric and real time techniques. Average PM10 concentrations found in the schools ranged from 55 ug m-3 to 91 ug m-3. These pollutant concentrations are above the World Health Organization reference values. Significant differences in PM10 concentrations were observed between the schools located in urban roads and the school located in the semi-rural area. The present work corresponds to the base line results of a longitudinal study that is still being conducted. These results demonstrate the importance of continuing developing research aimed at characterizing the range of atmospheric pollutants at major city roads environs in Bogota.
CONCERNING THE PREVENTION OF INDIVIDUAL LABOUR DISPUTES
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Venediktov Serhii
Published: May 2024

The paper analyses the peculiarities of prevention of labor disputes through the implementation of grievance procedures at the enterprise level. The existing mechanisms for resolving individual labor disputes in Ukraine cannot be called fully effective, which is primarily due to the lack of balanced legislative regulation of this issue. In addition, the result of the resolution of an individual labor dispute does not always lead to the satisfaction of the interests of both sides of the employment relationship – the employee and the employer. In this regard, an important place in the current labor law belongs to the procedures for preventing labor disputes. These procedures are generally implemented at the local level, through the prism of consideration by the employer of the grievances of employees related to the existing conflict situations in the working environment. National legislation does not contain any requirements for employers to deal with employee grievances. Such procedures can be part of the employer's internal labor rules and regulations, or be developed in the form of a separate local normative act of the employer. The grievance procedures are not uniform and primarily depend on the organizational structure and economic capabilities of a particular employer. But in any case, such procedures must: be developed and approved with the active participation of trade unions or other employee representatives; set quick deadlines for implementation and avoid unnecessary formalism; contain effective measures to ensure the safety of confidential information; be simple in content; ensure that employees are informed of all steps and measures taken as part of the grievance procedure; ensure the right of employees to be accompanied by trade union representatives or other employees at all stages of consideration of complains; ensure the principle of equal rights and opportunities for men and women. The adoption of the grievance procedures at the enterprise enables employees and employers to independently resolve individual conflicts that arise in the field of work and may subsequently result in labor disputes. A properly functioning procedure for handling employee claims will not only help prevent labor disputes, but will also allow prediction and elimination of their occurrence in the future. In addition, the existence of such a procedure, which is also aim at resolving conflict situations directly between employees, will have its overall positive effect, strengthening among employees a sense of fairness, coherence of interests and trust in the employer.
Right to Work: Challenges of Experimental Legal Regimes
Authors: Shonia G. V.
Published: May 2024

The right to work, being a fundamental right of any person, acquires special significance in the context of the introduction of digital technologies, and, above all, the implementation of experimental legal regimes. Experimental legal regimes that involve the use of a simplified approach to the legal regulation of certain social relations are associated with a number of theoretical and practical problems in the implementation of the right to work. As part of the study, in order to find a solution to these problems, the basic characteristics of innovative specialties and professions were identified. This allowed the author to formulate a definition of the concepts “innovative specialty” and “innovative profession”. Based on conceptual approaches to the legal regulation of relations within the framework of experimental legal regimes, the article proposes to use an imperative method of regulating relations for the employee to perform an innovative labor function within the framework of the employer’s activities on the basis of these legal regimes. Certain directions for improving regulatory legal and other acts in the field of standardization of professional activities of workers performing an innovative labor function are proposed.
Additional Measures to Support Families with Disabled Children
Authors: Potapova N. D.
Published: May 2024

The article presents an analysis of certain legislative norms aimed at maintaining the stability of the legal status of workers with disabled children. Based on statistical data, some positive results of state policy in the field of social support for families with a disabled child are noted, a conclusion is made about the stabilization of the growth rate of child disability at the present stage in comparison with indicators of previous years, the importance of additional benefits and guarantees provided to employees with disabilities is emphasized. a disabled child, both at the federal, regional and collective bargaining levels of legal regulation of labor. The author substantiates proposals for improving certain norms of labor legislation regarding the procedure for providing additional days off to working parents with disabled children, which will strengthen the emerging trend of stabilizing the social situation of these subjects.
Stability of Employment Relations upon Termination of Employment Contract at the Employer’s Initiative
Authors: Mihalskaya A. O.
Published: May 2024

This article assesses the stability of labor relations in modern conditions upon termination of an employment contract at the initiative of the employer. Four stages of events of the 21st century are identified, which directly determine the stability of labor relations in the event of termination of an employment contract with proactive employers in the Russian Federation, as well as in foreign countries. The author concludes that in order to maintain sustainable economic stability in the labor market, the state must take support measures not only for producers, but also for employers.
Evaluation of Violence Against Physicians: Sivas Province Example
Authors: Akgül Gültekin , Yıldırım Ali , Yücel Beyaztaş Fatma
Published: May 2024

Amaç: Sağlık kurumlarında yaşanan şiddet olayları, hekimler başta olmak üzere tüm sağlık çalışanlarını olumsuz yönde etkileyen bir durumdur. Bu araştırma, hekimlerin işyeri şiddetine maruz kalma sıklıklarını, şiddete karşı verdikleri tepkileri ve şiddetin nedenleri ile şiddete karşı çözüm önerilerini belirlemek amacıyla planlanmıştır.
Gereç ve Yöntem: Bu doğrultuda, araştırmanın çalışma grubu Sivas il merkezinde çalışan 24-72 yaş aralığındaki toplam 290 gönüllü hekimden oluşmaktadır. Bu çalışmada hekimlerin sosyodemografik özelliklerine, çalışma durumu ile ilgili bilgilerine, hekimlerin maruz kaldıkları şiddete ait değişkenlere, hekimlerin şiddetin nedenleri, sonuçları ve çözüm önerileri hakkındaki düşüncelerine yer veren 49 sorudan oluşan bir anket kullanılarak veriler toplanmıştır. Elde edilen veriler SPSS 22.0 programı kullanılarak analiz edilmiştir.
Bulgular: Çalışma ortamında en az bir kez şiddete maruz kalan hekimlerin oranının %57,9 olduğu, kadın cinsiyete sahip olan, dahili branşlarda çalışan, 16 yıl ve üzeri meslek hayatı olan hekimlerin daha çok şiddete maruz kaldığı ve şiddete maruz kalan hekimlerin %49,4’ünün şikayetçi olduğu sonucu elde edilmiştir. Şiddet türlerinin arasında psikolojik/sözel şiddetin fazla (%82,1) olduğu, şiddet uygulayanlar arasında en fazla hasta ve hasta yakınlarının yer aldığı saptanmıştır.
Sonuç: Şiddet olaylarını ve şiddetin olumsuz etkilerini önleyebilmek için; etkin  güvenlik önemler alınmalı, şiddet olaylarına karşı caydırıcı yasal düzenlemeler yapılmalı, şiddet olaylarına yönelik farkındalık düzeyi artırılmalı, sağlık çalışanlarına şiddetin etkileri ve başa çıkma konusunda destek ve eğitim verilmeli, hekimlerin çalışma koşulları iyileştirilmelidir.
Evaluation of the Relationship Between Suspicion of Abuse/Neglect and Depression in Individuals Over 65 Years of Age: Self-Awareness Study
Authors: Turla Ahmet , Kuloğlu Muhammet Mustafa , Cankurt Ayar Nilay
Published: May 2024

Objective: This study aims to evaluate abuse and neglect in the elderly, its relationship with depression, and insight in those suspected of abuse and neglect.
Methods: The population of the study consisted of 307 elderly individuals who applied to the outpatient clinics of Ondokuz Mayis University Hospital, who could read, write and had no speech or comprehension problems. In addition to questions on sociodemographic characteristics; the Yesavage Geriatric Depression Scale, Elder Abuse Suspicion Index and a question about patients' self-awareness of individual abuse-neglect were used as data collection tools.
Results: The possibility of depression was higher in primary school graduates, those who lived with family members or caregivers, and those with chronic illness. Suspicion of abuse was higher in primary school graduates, those who lived with family members or caregivers, those who had no income of their own, those with chronic illness and those who were taking psychiatric medication. Among the cases with suspicion of abuse, 58.8% were of the opinion that they had not been abused (p<0.05 for each). When the relationship between cases with suspected abuse and suspected depression was analyzed, a statistically moderate positive correlation between them (r=0.529, p<0.001) was found.
Conclusion: In our study, the low rate of cases with self-awareness and suspicion of abuse indicates the importance of informing the elderly about abuse and neglect, teaching which behaviours should be considered as abuse and neglect. The elderly who are aware of being abused and neglected will be more willing and courageous to seek help.
Measurement of Pen Pressure of Offline Signatures Using 3D Digital Microscopy and Its Utility in Determining Authorship
Authors: Kaya Dilara Öner , Çetin Gürsel
Published: May 2024

Objective: Two of the most frequently used diagnostic criteria in writing and signature comparisons are the degree of pen pressure and variations in pen pressure. However, in today’s practice, this criterion is inferentially evaluated only by naked eye or using image enhancer tools. This situation may cause various results among examiners, and difficulties in judicial procedure in terms of forensic handwriting and signature examinations, which has already been criticized for subjectivity. In this study, it is aimed to measure the depth of the indented pen pressure numerically in offline signatures and to evaluate it more objectively compared to the classical methods.
Methods: Note that 10 male and 10 female subjects participated in this study. Subjects were asked to imitate the signature shown as an example on three different surfaces. This signature was imitated by the subjects three times on different surfaces via free-hand (practise and non practice). Depth measurements were taken from five different points on the signature using a Leica DVM-6 3D Digital Microscope and compared with the genuine signature.
Results: Statistically significant differences were reported at different confidence intervals in comparisons considering different combinations.
Conclusion: In conclusion, aside from similar depth of the indented pen pressure, persistence of dissimilarities in different comparison documents and at different points is an important criterion. It has been revealed that these differences are statistically significant.
Efficacy of immunotherapy in advanced gastric cancer: preliminary results of a multicenter observational study
Authors: Rays A. B. , Fedyanin М. Yu. , Popov D. V. , Pokataev I. А. , Lyadova М. A. , Zhukova L. G. , Stroyakovsky D. L. , Volkonsky М. V. , Gavrilova D. А. , Besova N. S. , Tryakin А. А.
Published: May 2024

Background: Due to the low efficacy of PD-L1 antibodies in second and subsequent lines of metastatic gastric cancer (mGC), the optimal treatment strategy of such patients and appropriate choice of predictive biomarkers remain challenging.

   The aim of our study is to assess the efficacy of immune checkpoint inhibitors monotherapy in patients with mGC in routine clinical practice, especially in heavily-pretreated patients.

   Materials and methods: We retrospectively analyzed data of patients treated in five oncology centers in Moscow between 2018 and 2023, who received nivolumab or pembrolizumab for advanced gastric cancer. Primary end-point of our study was 6-months PFS. Secondary end-points were overall survival (OS), objective respons e rate (ORR), and disease control rate (DCR). Toxicity was assessed using CTC AE v5.0 scale.

   Results: 122 patients with mGC who received immune checkpoint inhibitors were included between 1 January 2018 and 28 February 2023. 6-months PFS rate was 31,6 %. The median OS was 7 months (95 % CI: 2–20), the median PFS was 3 months (95 % CI: 1,5–9,5). A statistically significant difference in OS was detected in patients with MSI compared to MSS (25 months vs 6 months; 95 % CI: 0,21–0,86; HR: 0,43). A trend towards higher PFS was observed as well (10 months in MSI vs 3 months in MSS; 95 % CI:0,26–1,01; HR: 0,51). No statistical significance in PFS and OS according to PD-L1 CPS was found among patients with MSS. ORR and DCR were 36,6 % and 10,6 %, respectively. No cases of pseudoprogression or fatal immune-related AEs were observed.

   Conclusion: Our real-world data is consistent with published literature and the results from clinical trials. Further studies are needed to determine prognostic factors and to establish prognostic model of patients receiving ICIs for optimal treatment strategy of mGC.
Enhanced PSO Optimized Leader in Cloud-Fog Task Scheduling for IoT and Mobile Crowdsensing Environments
Authors:   Department of Computer Science, Faculty of Computer Science and Mathematics, University of Kufa, Najaf, Iraq, Al-muqarm Abbas M. Ali
Published: May 2024

The data generated by the IoT needs a powerful platform such as cloud computing for data processing. However, the cloud faces challenges when dealing with various types of resources, high delay, and cost, this represents a substantial challenge in scheduling tasks. Therefore, the need appeared to introduce the concept of fog. To address these limitations, optimization algorithms such as PSO were used. In traditional PSO, all particles in the swarm are influenced by a single global best particle (Gbest), if it becomes stuck in a local optimum, all the particles will move closer to it, thus, the PSO may easily get trapped in premature convergence. This paper proposed an adaptive cloud-fog integrated approach based on modified PSO called PSO Optimized Leader (PSO-OL). These modifications on four stages: Firstly, a method to ensure swarm diversity in the initialization phase is introduced. Secondly, to reduce the chance of the population getting trapped in a local optimum, the farthest-best particle is introduced. Third, in addition to the primary Gbest, a second Gbest represents a different good particle presented to explore multiple promising regions. Finally proposed a new crossover operator to get an optimized leader. The PSO-OL approach was evaluated and the results show the effectiveness of the enhanced leader by 40% with farthest-best, 45% with second-Gbest when compared to standard PSO, and when compared to scheduling algorithms where outperforms the other algorithms by minimizing makespan by 34%, cost by 14%, and increasing throughput by 75%, in comparison to existing load balancing and scheduling methods: RR, BLA, MPSO, ETS, and TCaS.
A Study of High-Speed Hamming Distance Detection Circuit Utilizing a Neuron CMOS Inverter
Authors:   Research Institute of Science and Technology, Tokai University, Kanagawa, Japan, Nishiguchi Daishi
Published: May 2024

This study tackles the challenge of optimizing associative memory for efficient data retrieval from large databases, crucial in real-time processing. The authors specifically address the issue of increased detection time in the minimum Hamming distance search associative memory, particularly as the number of data bits grows. This memory system utilizes Hamming distance as a key metric to identify the most similar reference data. Our contribution is the development of a new Hamming distance detection circuit employing neuron Complementary Metal Oxide Semiconductor (CMOS) inverters. This proposed circuit significantly outperforms existing models in terms of operational speed. The effectiveness and improved performance of the circuit are validated through simulations using HSPICE, a type of Simulation Program with Integrated Circuit Emphasis (SPICE) demonstrating its potential for more efficient real-time data retrieval applications.
Research on Medium Capacity Rail System: Case on Pham Van Dong Route in Ho Chi Minh City, Vietnam
Authors:   Science and Technology Application for Sustainable Development Research Group (STASD), Ho Chi Minh City University of Transport, Ho Chi Minh City, Vietnam, Van Dong Doan
Published: May 2024

This paper delves into the study and proposition of a Medium Capacity Rail System (MCS) model to tackle urban traffic issues, both in the immediate future and, more specifically, the public transportation challenges along the Pham Van Dong (PVD) route. Drawing from statistical surveys and an in-depth analysis of motorcycle traffic patterns at intersections during near-peak and peak hours in the morning and afternoon along PVD’s main artery in the northeastern part of Ho Chi Minh City (HCMC), Vietnam. Moreover, this research explores the relatively new concept of MCS, which have gained traction in recent years due to their distinct advantages over existing systems. The findings in this article underscore the practicality of the proposal and provide a blueprint for sustainable, integrated urban transport development, improve traffic flow, reduce congestion, reduce environmental pollution and enhance a complete and modern urban railway network for Ho Chi Minh City or other similar global scenarios.
SEL4C: Mobile Application for the Development of Social Entrepreneurship Competency
Authors:   Institute for the Future of Education, Tecnológico de Monterrey, Monterrey, México, Vázquez-Parra José Carlos
Published: May 2024

Universities must ensure their students acquire competencies that empower them to act as genuine catalysts for transformation. This necessitates, beyond imparting disciplinary skills and knowledge, the integration of cross-disciplinary competencies to equip them to navigate the complexities of their surroundings effectively. This study delineates the outcomes from deploying a mobile application aimed at fostering entrepreneurial intent among students at a technological university in Mexico. The objective was to enhance the perception of attainment in social entrepreneurship skills among students from fields not traditionally linked to business or entrepreneurship. From a methodological standpoint, a multivariate descriptive analysis was conducted using R software and RStudio, incorporating mean analyses, with further insights provided by violin and box plots. The findings reveal that the mobile application significantly contributes to the cultivation of social entrepreneurship skills, establishing itself as a feasible and pertinent technological instrument for nurturing agents of change. Notably, while female students exhibited superior average scores, male students demonstrated more considerable development in these competencies. This research is situated within the domain of Technology Applied to Education and Educational Initiatives via Mobile Applications.
Impact of Website Stimuli on Online Impulse Buying: A Quantitative Analysis
Authors:   Department of Decision Science, Faculty of Business and Economics, Universiti Malaya, Kuala Lumpur, Malaysia, Phoong S. W.
Published: May 2024

Understanding the factors that influence consumers to buy impulsively in an online context has become increasingly important to businesses nowadays in order to help them stay competitive in the intensively competitive e-commerce market. Though existing literature has demonstrated how a website can improve the shopping experience and influence online shoppers to buy impulsively, the focus is more on design and quality dimensions such as visual appeal, website navigability, ease of use, etc. A more detailed analysis of how the advanced technology-supported website stimuli like recommender system, information search, customer services, and privacy & data security influence the consumer shopping experience and impulse buying behavior is still needed. Based on a Stimulus-Organism-Response model’s conceptual framework and 403 valid respondents collected via an online questionnaire, this study aims to identify and explore the influence of advanced technology-supported website stimuli on customer satisfaction and online impulse buying behavior in the Malaysian context. The results showed that the recommender system, information search, and customer service had a significant influence on customer satisfaction, and the latter significantly impacted online impulse buying behavior.
Role of defective mirror neurons in causing autism spectrum disorder and the effectiveness of current treatment strategies for autism
Authors: Javed Eman , Masood Fareeha , Elahi Naz
Published: May 2024

The presence of mirror neurons (MN) in the premotor cortex, and parietal regions of the brain, has always been an area of interest to neurophysiologists, because unlike most neurons, they are activated, not only while an individual is performing an action, but also when one witnesses another experiencing a sentiment, and hence, is compelled to do the same. This phenomenon, helps develop empathy, as well as an individual's social behavior. Autism spectrum disorder (ASD) is defined as a socially isolating disease, and has been hypothesised to be caused by defective MNs. According to the World Health Organization (WHO), about 1 out of every 100 children suffer from ASD. Although many studies have proven that the impaired MN system is the underlying cause of the cognitive function defects seen in these individuals, the exact role it plays in causing the disease is still unclear.
Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway
Authors:   Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, Shaanxi Province, China; First Affiliated Hospital of Northwest University, Northwest University, Xi’an 710069, Shaanxi Province, China; Department of Ophthalmology, Xi’an No.1 Hospital, Xi’an 710002, Shaanxi Province, China, Zhu Yu-Sheng , Zhang Hui-Hui ,   Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, Shaanxi Province, China; First Affiliated Hospital of Northwest University, Northwest University, Xi’an 710069, Shaanxi Province, China; Department of Ophthalmology, Xi’an No.1 Hospital, Xi’an 710002, Shaanxi Province, China, Wang Tong ,   Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, Shaanxi Province, China; First Affiliated Hospital of Northwest University, Northwest University, Xi’an 710069, Shaanxi Province, China, Chen Xiao-Dong ,   Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, Shaanxi Province, China; First Affiliated Hospital of Northwest University, Northwest University, Xi’an 710069, Shaanxi Province, China
Published: May 2024

AIM: To explore the effect of epidermal growth factor receptor (EGFR) inhibition by erlotinib and EGFR siRNA on epidermal growth factor (EGF)-induced activation of retinal pigment epithelium (RPE) cells.
METHODS: Human RPE cell line (ARPE-19 cells) was activated by 100 ng/mL EGF. Erlotinib and EGFR siRNA were used to intervene EGF treatment. Cellular viability, proliferation, and migration were detected by methyl thiazolyl tetrazolium (MTT) assay, bromodeoxyuridine (BrdU) staining assay and wound healing assay, respectively. EGFR/protein kinase B (AKT) pathway proteins and N-cadherin, α-smooth muscle actin (α-SMA), and vimentin were tested by Western blot assay. EGFR was also determined by immunofluorescence staining.
RESULTS: EGF treatment for 24h induced a significant increase of ARPE-19 cells’ viability, proliferation and migration, phosphorylation of EGFR/AKT proteins, and decreased total EGFR expression. Erlotinib suppressed ARPE-19 cells’ viability, proliferation and migration through down regulating total EGFR and AKT protein expressions. Erlotinib also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin, α-SMA, and vimentin proteins. Similarly, EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation, viability, and migration, phosphorylation of EGFR/AKT proteins, and up-regulation of N-cadherin, α-SMA, and vimentin proteins.
CONCLUSION: Erlotinib and EGFR-knockdown suppress EGF-induced cell viability, proliferation, and migration via EGFR/AKT pathway in RPE cells. EGFR inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy (PVR).
Ocular surface changes in moderate-to-severe acne vulgaris
Authors:   Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China, Pan Ci-Yi , Li Han-Ling ,   Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China, Ma Li ,   Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China, Zhang Min ,   Department of Stomatology, the First People’s Hospital of Yunnan Province, Kunming 650100, Yunnan Province, China, Tang Song-Yuan ,   Institute of Health Studies, School of Public Health, Kunming Medical University, Kunming 650500, Yunnan Province, China, Zhang Hui ,   Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Published: May 2024

AIM: To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry eye.
METHODS: This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy controls. The participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The following ocular surface-related parameters were measured: tear meniscus height (TMH), noninvasive tear breakup time (NIBUT), Schirmer I test (SIT), lipid layer thickness (LLT) score of the tear film, meibum score, meibomian gland orifice obstruction score, the ratio of meibomian gland loss, conjunctival hyperemia score, and corneal fluorescein staining (CFS) score.
RESULTS: The stability of the tear film decreased in acne vulgaris patients. In the acne group, the TMH and NIBUT were lower, whereas the OSDI, meibum score, meibomian gland orifice obstruction score, ratio of meibomian gland loss, and conjunctival hyperemia score were higher compared with controls (P<0.05). There were no significant differences in the CFS score, SIT, or LLT score between the groups (P>0.05). In two dry eye groups, the TMH, NIBUT, and LLT score were lower in the acne with dry eye (acne-DE) group, and the meibum score, meibomian gland orifice obstruction score, ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher (P<0.05). There were no significant differences between OSDI, SIT, and CFS score (P>0.05).
CONCLUSION: Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne vulgaris. Reduced tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.
Talking about the Influence of Human Resource Management on Enterprise Development under the New Situation
Authors: Jiang Zuoming , Li Daisheng , Zhou Yongqi
Published: May 2024

With the advent of knowledge economy, international competition is becoming increasingly fierce, human resources management in the role of enterprise management is growing. In the 21st century, the trend of globalization of the world economy has been strengthened, and the development of science and technology has been changing with each passing day. The essence of comprehensive national competition is becoming the competition of human resources. Similarly, enterprises in order to compete in the fierce and healthy development, we must reduce costs and improve management efficiency, must have a set of their own talent management methods. Human resources are the most important resources in all resources, effectively play the important role of human resources in the core competitiveness, and formulate the countermeasures of human resource competition, which is of great significance to improve the core competitiveness of enterprises. In the new century to further improve the management of human resources in state-owned enterprises, improve China's enterprise human resources management system is to enliven the state-owned enterprises, improve our comprehensive national strength of the top priority, to promote China's economic development is of great significance.
Communication in Human Resource Management
Authors: Sun Haiquan , Liu Jinyu , Chen Hang
Published: May 2024

Communication is an important part of organizational management activities and management behavior. In human resource management, effective communication plays an extremely important role. Human resources as one of the most critical resources of enterprises, the effectiveness of management is directly related to the survival and development of enterprises. Communication is the process of communication and transmission of information, effective communication is an important magic weapon for each enterprise to gain competitive advantage and success. This paper summarizes the important position and function of communication in enterprise human resource management, and puts forward the basic viewpoints and suggestions on how to establish the management communication mode from the perspective of human resource management.