bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Discovery and Structure—Activity Study of a Novel Benzoxaborole Antiinflammatory Agent (AN2728) for the Potential Topical Treatment of Psoriasis and Atopic Dermatitis.
Authors: Akama Tsutomu , Baker Stephen J. , Zhang Yong‐Kang , Hernandez Vincent , Zhou Huchen , Sanders Virginia , Freund Yvonne , Kimura Richard , Maples Kirk R. , Plattner Jacob J.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Diphenyl Phosphide and Substituted Phosphines Using Alkali Metal in Silica Gel (M—SG).
Authors: Nandi Partha , Dye James L. , Bentley Philip , Jackson James E.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Preparation of 2,6‐Disubstituted Pyridinyl Phosphine Oxides as Novel Anticancer Agents.
Authors: Lam Kim Hung , et al. et al.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isocyanide‐Based Two‐Step Three‐Component Keteneimine Formation.
Authors: Coffinier Didier , El Kaim Laurent , Grimaud Laurence
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Bioactivity of Some New 2‐(Alkoxy carbonyl alkyl)‐6‐bromo‐3,4‐dihydro‐3‐(α‐methyl benzyl)‐2‐oxobenzo[e][2H‐1,3,2‐oxazaphosphinine] Derivatives.
Authors: Srinivasulu K. , Suresh Kumar K. , Hari Babu B. , Stephen Babu M. F. , Naga Raju C. , Suresh Reddy C.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Application of Novel Styryl Dyes Derived from 1,4‐Diethyl‐1,2,3,4‐tetrahydro‐6‐methoxyquinoxaline.
Authors: Satam Vijay , Rajule Rajkumar , Bendre Samir , Bineesh Purushotthaman , Kanetkar Vinod
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2‐Ene‐1,4‐diols by a New Cascade‐Opening of 1,3‐Diepoxides: Towards an Efficient Synthesis of Dihydroxytaxoid Derivatives.
Authors: Aldegunde Maria J. , Castedo Luis , Granja Juan R.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ozonolysis of Verbenone in Aprotic Solvents.
Authors: Kukovinets Olga S. , Zvereva Tatyana I. , Kabalnova Natalya N. , Kasradze Vakhtang G. , Salimova Elena V. , Khalitova Lyucia R. , Abdullin Marat I. , Spirikhin Leonid V.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Steroid Sulfamates and Their Interaction with GABAA Receptor.
Authors: Kapras Vojtech , Stastna Eva , Chodounska Hana , Pouzar Vladimir , Kristofikova Zdena
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Evaluation of Some Thiazolidinone Derivatives of Steroid as Antibacterial Agents.
Authors: Khan Salman Ahmad , Yusuf Mohammed
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidant‐Controlled Heck‐Type C‐Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2‐Deoxy‐C‐glycosides.
Authors: Xiong De‐Cai , Zhang Li‐He , Ye Xin‐Shan
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Kinase Inhibitory Potencies and in vitro Antiproliferative Activity of Isoindigo and 7′‐Azaisoindigo Derivatives (V) Substituted by Sonogashira Cross‐Coupling.
Authors: Bouchikhi Fadoua , Anizon Fabrice , Moreau Pascale
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Total Synthesis of (‐)‐Frontalin, (‐)‐endo‐Brevicomin and (‐)‐exo‐Brevicomin Through PtCl4 Catalyzed Hydroalkoxylation Reaction.
Authors: Lee Hee‐Yoon , Jung Yongsik , Moon Hyunsik
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Cyclization of Allenoates Containing Carbonyl Functionalities Mediated Mo(CO)6: Synthesis of Canadensolide and Sporothriolide.
Authors: Kwon Jisook , Gong Suyeon , Woo Seok‐Hoon , Yu Chan‐Mo
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrazine Borane: A Promising Hydrogen Storage Material.
Authors: Huegle Thomas , Kuehnel Moritz F. , Lentz Dieter
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Piperidinyl‐2‐phenethylamino Inhibitors of DPP‐IV for the Treatment of Type 2 Diabetes.
Authors: Benbow John W. , et al. et al.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1‐(5‐Carboxyindol‐1‐yl)propan‐2‐ones as Inhibitors of Human Cytosolic Phospholipase A2α: Synthesis and Properties of Bioisosteric Benzimidazole, Benzotriazole and Indazole Analogues.
Authors: Bovens Stefanie , Kaptur Martina , Schulze Elfringhoff Alwine , Lehr Matthias
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: GPR109a Agonists. Part1. 5‐Alkyl and 5‐Aryl‐pyrazole‐tetrazoles as Agonists of the Human Orphan G‐Protein Coupled Receptor GPR109a.
Authors: Imbriglio Jason E. , et al. et al.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Discovery of Novel Dihydro‐9,10‐ethano‐anthracene Carboxamides as Glucocorticoid Receptor Modulators.
Authors: Yang Bingwei V. , et al. et al.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Physics and Applications of Bismuth Ferrite
Authors: Catalan Gustau , Scott James F.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isomerism in the Chemistry of Organogermanium Compounds (Part II)
Authors: Melnik Milan , Garaj Jan
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural and Biological Chemistry of Organotin(IV) Complexes
Authors: Ali Saqib , Shahzadi Saira , Bhatti Moazzam H.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Half‐Sandwich Ruthenium Complexes Containing Water‐Soluble Phosphine Ligands: Catalytic Applications
Authors: Cadierno Victorio , Crochet Pascale
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalyzed Direct Asymmetric α‐Halogenation of Carbonyl Compounds
Authors: Ueda Mitsuhiro , Kano Taichi , Maruoka Keiji
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanographene and Nanodiamond; New Members in the Nanocarbon Family
Authors: Enoki Toshiaki , Takai Kazuyuki , Osipov Vladimir , Baidakova Marina , Vul' Alexander
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels—Alder “Click” Chemistry in Designing Dendritic Macromolecules
Authors: Franc Gregory , Kakkar Ashok K.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Epibatidine Analogues Synthesized for Characterization of Nicotinic Pharmacophores
Authors: Carroll F. Ivy
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1α,25‐Dihydroxy‐2β‐(3‐hydroxypropoxy)vitamin D3 (Eldecalcitol) and Related Compounds by the Trost Convergent Methodology.
Authors: Kubodera Noboru , Hatakeyama Susumi
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (‐)‐Indolizidine 167B via 4‐Pyrrolylbutanals: Two Synthetic Methodologies at Comparison.
Authors: Settambolo Roberta
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Radical Cyclization for the Synthesis of Cyclic Compounds
Authors: Yoshioka Eito , Kohtani Shigeru , Miyabe Hideto
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tactics and Strategies for the Synthesis of Iminosugar C‐Glycosides
Authors: Compain Philippe , Chagnault Vincent , Martin Olivier R.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Properties of Diaza‐, Triaza‐, and Tetraazaphenothiazines
Authors: Pluta Krystian , Morak‐Mlodawska Beata , Jelen Malgorzata
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Annulation and Arylation Stabilize New Porphyrinoids
Authors: Jux Norbert
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development
Authors: Guile Simon D. , Alcaraz Lilian , Birkinshaw Timothy N. , Bowers Keith C. , Ebden Mark R. , Furber Mark , Stocks Michael J.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents
Authors: Singh Shailendra , Bharti Neelam , Mohapatra Prabhu P.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Advances in Soluion‐ and Solid‐Phase Synthesis Toward the Generation of Natural Product‐Like Libraries
Authors: Nandy Jyoti P. , Prakesch Michael , Khadem Shahriar , Reddy P. Thirupathi , Sharma Utpal , Arya Prabhat
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Backbone Amide Linker in Solid‐Phase Synthesis
Authors: Boas Ulrik , Brask Jesper , Jensen Knud J.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Construction of Nitrogen‐Containing Heterocycles by C—H Bond Functionalization
Authors: Thansandote Praew , Lautens Mark
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silicon Analogues of Polyfluorene as Materials for Organic Electronics
Authors: Wong Wallace W. H. , Hooper Joel F. , Holmes Andrew B.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Addition of Achiral Organomagnesium Reagents or Organolithiums to Achiral Aldehydes or Ketones
Authors: Luderer Matthew R. , Bailey William F. , Luderer Mark R. , Fair Justin D. , Dancer Robert J. , Sommer Michael Bech
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid‐Phase Assembly
Authors: Cudic Mare , Burstein Gayle D.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose Membranes
Authors: Winkler Dirk F. H. , Campbell William D.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bisubstrate Analogues as Glycosyltransferase Inhibitors
Authors: Izumi Masayuki , Yuasa Hideya , Hashimoto Hironobu
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Methodology Towards Aryl‐1, 2‐Azoles
Authors: Mahalingam Sakkarapalayam M. , Pati Hari N.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry and Pharmacology of Benzodioxanes
Authors: Ahmed Bahar , Habibullah Habibullah , Khan Shamshir
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesizing Interlocked Molecules Dynamically
Authors: Haussmann Philip C. , Stoddart J. Fraser
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Activity of Selected Carbocyclic Nucleosides
Authors: Mieczkowski Adam , Agrofoglio Luigi A.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Properties of Oligonucleotides Incorporating Modified Nucleobases Capable of Watson—Crick‐Type Base‐Pair Formation
Authors: Sekine Mitsuo , Ohkubo Akio , Okamoto Itaru , Seio Kohji
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coupling of Screen‐Printed Electrodes and Magnetic Beads for Rapid and Sensitive Immunodetection: Polychlorinated Biphenyls Analysis in Environmental Samples
Authors: Centi S. , Marrazza G. , Mascini Marco
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Spectroscopy Applied to Photochromism Investigations
Authors: Delbaere Stephanie , Vermeersch Gaston
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Serum macrophage migration‐inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer
Authors: Xia Harry Hua‐Xiang , Yang Yi , Chu Kent‐Man , Gu Qing , Zhang Yuan‐Yuan , He Hua , Wong Wai Man , Leung Suet‐Yi , Yuen Siu‐Tsan , Yuen Man‐Fung , Chan Annie O.O. , Wong Benjamin C.Y.
Published: August 2009

BACKGROUND:

This study aimed to determine the potential diagnostic value of migration‐inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer.

METHODS:

A cohort of 97 patients with histologically confirmed gastric adenocarcinoma and 222 patients with dyspepsia were recruited. Enzyme‐linked immunosorbent assay was used to measure serum MIF and carcinoembryonic antigen (CEA).

RESULTS:

The serum MIF concentrations were 6554.0 ± 204.1 pg/mL and 1453.7 ± 79.9 pg/mL, respectively, in gastric cancer patients and dyspeptic patients (P < .001). Serum MIF levels increased with the advancing gastric pathologies (P < .001). With the cutoff value of 3230 pg/mL, serum MIF had sensitivity, specificity, and accuracy of 83.5%, 92.3%, and 89.7%, respectively, in diagnosing gastric cancer, whereas the rates were 60.8%, 83.3%, and 76.5%, respectively, for serum CEA. Gastric cancer patients with serum MIF levels above 6600 pg/mL had a lower 5‐year survival rate than those with serum MIF level below that level (P = .012). Higher serum CEA levels were also associated with poor survival. The prediction for 5‐year survival was even better (P = .0001), using a combination of serum MIF and CEA.

CONCLUSIONS:

Serum MIF level, which correlates with gastric MIF expression, is a better molecular marker than CEA in diagnosing gastric cancer in patients presenting with dyspepsia. A combination of serum MIF and CEA predicts 5‐year survival better than the individual test. Cancer 2009. © 2009 American Cancer Society.
Postoperative radiation therapy after complete resection of thymoma has little impact on survival
Authors: Utsumi Tomoki , Shiono Hiroyuki , Kadota Yoshihisa , Matsumura Akihide , Maeda Hajime , Ohta Mitsunori , Yoshioka Yasuo , Koizumi Masahiko , Inoue Takehiro , Okumura Meinoshin
Published: August 2009

BACKGROUND:

Postoperative radiation therapy for thymoma is widely used, although the clinical benefits are controversial. Furthermore, to the authors' knowledge, the relation between postoperative radiation therapy and cell type classified by the World Health Organization (WHO) is not known.

METHODS:

The records of 324 patients (ages 17‐83 years; mean, 51 years; 160 males and 164 females) who underwent complete resection of a thymoma between 1970 and 2005 were reviewed. Mediastinum postoperative radiation therapy was performed for 134 patients. Survival rates and patterns of recurrence were determined according to Masaoka stage and WHO cell type.

RESULTS:

The 10‐year disease‐specific survival rates for patients with and without postoperative radiation therapy were 92.8% and 94.4%, respectively (P = .22). Subset analyses after stratifying by Masaoka stage and WHO cell type demonstrated that the 10‐year disease‐specific survival rate for patients without postoperative radiation therapy with Masaoka stage I and II, as well as those with WHO cell types A, AB, or B1, was 100%, which was satisfactory. Furthermore, the rates for patients with Masaoka stage III/IV and those with WHO cell types B2/B3 with or without postoperative radiation therapy were not found to be significantly different. In 24 patients with disease recurrence, pleural dissemination was observed most often, followed by distant metastases; local disease recurrence without other recurrence occurred in 2.

CONCLUSIONS:

The authors concluded that surgical resection alone is sufficient for thymoma patients with Masaoka stage I and II, and those with WHO cell types A, AB, and B1. Furthermore, an optimal treatment strategy should be established for patients with Masaoka stage III/IV and WHO cell type B2/B3 thymomas. Cancer 2009. © 2009 American Cancer Society.
Care of long‐term cancer survivors
Authors: Pollack Lori A. , Adamache Walter , Ryerson A. Blythe , Eheman Christie R. , Richardson Lisa C.
Published: August 2009

BACKGROUND:

Studies have shown that follow‐up care for cancer patients differs by physician specialty, and that coordination between specialists and generalists results in better care. Little is known, however, regarding which specialties of physicians provide care to long‐term cancer survivors.

METHODS:

The authors used Surveillance, Epidemiology, and End Results data from 1992 through 1997 that were linked to 1997‐2003 Medicare data to identify persons diagnosed >5 years earlier with bladder, female breast, colorectal, prostate, or uterine cancer. Physician specialties were assigned by combining Medicare data with the American Medical Association Masterfile and the Unique Physician Identification Number Registry. The percentage of long‐term survivors who visited physicians of interest was determined by analyzing Medicare outpatient claims submitted 6 to 12 years after initial diagnosis.

RESULTS:

Over the entire study period, 46% of female breast cancer survivors, 26% of colorectal cancer survivors, and 14% of prostate cancer survivors saw hematologists/oncologists. Radiation oncologists were seen by 11%, 2%, and 14% of breast, colorectal, and prostate cancer survivors, respectively. Survivors also sought care from specialists related to their cancer: 19% of breast cancer survivors had a cancer‐coded visit with a surgeon, 26% of colorectal cancer survivors visited a gastroenterologist, and 68% of prostate cancer survivors visited a urologist. The percentage of survivors who visited cancer and cancer‐related physicians declined each year. In contrast, nearly 75% of female breast, colorectal, and prostate cancer survivors saw primary care providers, and these percentages did not decrease annually.

CONCLUSIONS:

The findings of the current study underscore the need to include both primary care providers and cancer‐related specialists in education and guidelines regarding cancer survivorship. Cancer 2009. © 2009 American Cancer Society.
Cost‐effectiveness analysis of immediate radical cystectomy versus intravesical Bacillus Calmette‐Guerin therapy for high‐risk, high‐grade (T1G3) bladder cancer
Authors: Kulkarni Girish S. , Alibhai Shabbir M. H. , Finelli Antonio , Fleshner Neil E. , Jewett Michael A. S. , Lopushinsky Steven R. , Bayoumi Ahmed M.
Published: August 2009

BACKGROUND:

Although both radical cystectomy and intravesical immunotherapy are initial treatment options for high‐risk, T1, grade 3 (T1G3) bladder cancer, controversy regarding the optimal strategy persists. Because bladder cancer is the most expensive malignancy to treat per patient, decisions regarding the optimal treatment strategy should consider costs.

METHODS:

A Markov Monte‐Carlo cost‐effectiveness model was created to simulate the outcomes of a cohort of patients with incident, high‐risk, T1G3 bladder cancer. Treatment options included immediate cystectomy and conservative therapy with intravesical Bacillus Calmette‐Guerin (BCG). The base case was a man aged 60 years. Parameter uncertainty was assessed with probabilistic sensitivity analyses. Scenario analyses were used to explore the 2 strategies among patients stratified by age and comorbidity.

RESULTS:

The quality‐adjusted survival with immediate cystectomy and BCG therapy was 9.46 quality‐adjusted life years (QALYs) and 9.39 QALYs, respectively. The corresponding mean per‐patient discounted lifetime costs (in 2005 Canadian dollars) were $37,600 and $42,400, respectively. At a willingness‐to‐pay threshold of $50,000 per QALY, the probability that immediate cystectomy was cost‐effective was 67%. Immediate cystectomy was the dominant (more effective and less expensive) therapy for patients aged <60 years, whereas BCG therapy was dominant for patients aged >75 years. With increasing comorbidity, BCG therapy was dominant at lower age thresholds.

CONCLUSIONS:

Compared with BCG therapy, immediate radical cystectomy for average patients with high‐risk, T1G3 bladder cancer yielded better health outcomes and lower costs. Tailoring therapy based on patient age and comorbidity may increase survival while yielding significant cost‐savings for the healthcare system. Cancer 2009. © 2009 American Cancer Society.
Differential Pulse Voltammetric Detection of Hepatitis C Virus 1a Oligonucleotide Chain by a Label‐Free Electrochemical DNA Hybridization Biosensor Using Consensus Sequence of Hepatitis C Virus 1a Probe on the Pencil Graphite Electrode
Authors: Pournaghi‐Azar M. H. , Ahour F. , Hejazi M. S.
Published: August 2009

The short sequence related to hepatitis C virus (HCV1) is detected by a label‐free DNA hybridization biosensor. The sensor relies on the immobilization of a 20‐mer oligonucleotide containing 2 guanine and 11 cytosine bases denoted PHCV1 as probe on the pencil graphite electrode (PGE). The hybridization event was monitored by differential pulse voltammetry (DPV) using the guanine signal. The selectivity of the biosensor was studied using some noncomplementary oligonucleotides. Diagnostic performance of the biosensor is described and the detection limit was found to be 6.5 nM.
Quantitative Photoelectrochemical Detection of Biotin Conjugated CdSe/ZnS Quantum Dots on the Avidin Immobilized ITO Electrodes
Authors: Baş Deniz , Boyacı İsmail Hakkı
Published: August 2009

Photocurrent generation from CdSe/ZnS (core/shell) quantum dots (QDs) in a photoelectrochemical cell was proposed to perform a bioaffinity biosensor in this study. The photocurrent of QDs is reversible and methylene blue as an electron transfer mediator causes a four‐fold increase in the photocurrent. We further present quantitative photoelectrochemical detection of biotin conjugated QDs on the avidin immobilized ITO electrodes. A linear calibration graph was obtained in the range of 4 and 18 nM of biotin conjugated QDs with a coefficient of determination of 0.997. Results imply that QDs can be successfully used as photoelectroactive labels for the photoelectrochemical biosensor systems.
Novel Sensitive Voltammetric Detection of Trace Gallium(III) with Presence of Catechol Using Mercury Film Silver Based Electrode
Authors: Piech Robert
Published: August 2009

A new adsorptive stripping voltammetric method for the determination of trace gallium(III) based on the adsorption of gallium(III)‐catechol complex on the cyclic renewable mercury film silver based electrode (Hg(Ag)FE) is presented. The effects of various factors such as: preconcentration potential and time, pulse height, step potential and supporting electrolyte composition are optimized. The calibration graph is linear from 2 nM (0.14 μg L−1) to 100 nM (6.97 μg L−1) for a preconcentration time of 30 s, with correlation coefficient of 0.9993. For a Hg(Ag)FE with a surface area of 9.7 mm2 the detection limit for a preconcentration time of 90 s is as low as 7 ng L−1. The repeatability of the method at a concentration level of the analyte as low as 0.05 μg L−1, expressed as RSD is 3.6% (n=5). The proposed method was successfully applied by studying the natural samples and simultaneous recovery of Ga(III) from spiked water and sediment samples.
Multiwalled Carbon Nanotubes Encased in Ruthenium Oxide Film as a Hybrid Material for Neurotransmitters Sensor
Authors: Ti Chien‐Chieh , Umasankar Yogeswaran , Chen Shen‐Ming
Published: August 2009

A hybrid film (MWCNTs‐RuOx⋅nH2O) which contains multiwalled carbon nanotubes (MWCNTs) along with the incorporation of ruthenium oxide (RuOx⋅nH2O) has been synthesized on glassy carbon electrode (GCE), gold (Au), indium tin oxide (ITO) and screen printed carbon electrode (SPCE) by potentiostatic methods. The presence of MWCNTs in the hybrid film enhances surface coverage concentration (Γ) of RuOx⋅nH2O to ≈2100%. The surface morphology of the hybrid film deposited on ITO has been studied using scanning electron microscopy and atomic force microscopy. These two techniques reveal that the RuOx⋅nH2O incorporated on MWCNTs. Electrochemical quartz crystal microbalance study too reveals the incorporation of MWCNTs and RuOx⋅nH2O. The MWCNTs‐RuOx⋅nH2O hybrid film exhibits promising enhanced electrocatalytic activity towards the biochemical compounds such as epinephrine and norepinephrine. The electrocatalytic responses of these analytes at RuOx⋅nH2O, MWCNTs and MWCNTs‐RuOx⋅nH2O hybrid films have been measured using cyclic voltammetry. The obtained sensitivity values from electrocatalysis studies of analytes for MWCNTs‐RuOx⋅nH2O hybrid film are higher than the RuOx⋅nH2O and MWCNTs films. Finally, the flow injection analysis has been used for the amperometric studies of analytes at MWCNTs‐RuOx⋅nH2O hybrid film modified SPCEs.
Prussian Blue Modified Carbon Ionic Liquid Electrode: Electrochemical Characterization and Its Application for Hydrogen Peroxide and Glucose Measurements
Authors: Haghighi Behzad , Nikzad Ramin
Published: August 2009

Prussian blue modified carbon ionic liquid electrodes (PB‐CILEs) were fabricated using chemical and electrochemical procedures. Chemically fabricated PB‐CILE exhibited an excellent sensitivity (0.0866 μA μM−1), low detection limit (0.01 μM) and two linear ranges (0.01–1 and 1–600 μM) toward hydrogen peroxide. Then, glucose oxidase (GOx) was immobilized on the surface of PB‐CILE to fabricate glucose biosensor using three different procedures involving cross linking with glutaraldehyde (GLU) and bovine serum albumin (BSA), entrapment into the Nafion matrix and covering with a sol‐gel layer. Glucose biosensor fabricated using cross linking procedure showed the best sensitivity (0.0019 μA μM−1) and operational stability for glucose.
RBC electrophoresis with discontinuous power supply – a newly established hemoglobin release test
Authors: Su Yan , Shao Guo , Gao Lijun , Zhou Lishe , Qin Liangyi , Qin Wenbin
Published: August 2009

In this paper, we aimed to introduce a newly established red blood cells (RBCs) electrophoresis method hemoglobin release test (HRT) and tried to determine its significance. Human blood samples from β‐thalassemia patients and healthy controls were analyzed with HRT, which was carried out on starch–agarose mixed gel. First, the whole blood samples were electrophoresed for 2 h, then paused for 15 min and ran for 15 min by turns. This “pause‐run‐pause” experiment was performed for several turns and the total electrophoresis time lasted for about 6 h. The results showed that some other hemoglobin (Hb) components were released from the origin of each sample during the HRT, and the samples from β‐thalassemia patients released more Hb than the healthy controls. This finding demonstrates that Hb may exist differently associated in RBCs, and it may have an important theoretical and clinical significance in Hb and RBC research.
Proteomic analysis of Oenococcus oeni freeze‐dried culture to assess the importance of cell acclimation to conduct malolactic fermentation in wine
Authors: Cecconi Daniela , Milli Alberto , Rinalducci Sara , Zolla Lello , Zapparoli Giacomo
Published: August 2009

Cultures of Oenococcus oeni, the most important malolactic bacterium, are used to induce malolactic fermentation in wine. Survival assays in two different wines confirmed that cells acclimated for 24 h in half‐strength wine‐like medium (acclimation medium) enhanced the malolactic performances. To investigate the effect of the pre‐incubation phase on cell physiology, a proteomic study was carried out. Total protein extracts of acclimated and non‐acclimated cell cultures (control) were analyzed by 2‐D‐PAGE. A total of 20 out of approximately 400 spots varied significantly. All the spots were identified by MS analysis and most of them were proteins involved in metabolism, transcription/translation processes and stress response. The results revealed the different physiological status between non‐acclimated and acclimated cells explaining, in part, their different behavior in wine. Regulation of stress proteins such as heat and cold shock proteins was involved. Moreover, the availability of sugars and amino acids (even if at low concentration) in acclimation medium determined a modulation of energy metabolism enhancing the resistance to stressful conditions (as those that cells find in wine when inoculated). Finally, this proteomic study increased knowledge concerning the physiological changes in freeze‐dried culture occurring with pre‐inoculation procedures.
Single‐step purification of the recombinant green fluorescent protein from intact Escherichia coli cells using preparative PAGE
Authors: Chew Few Ne , Tan Wen Siang , Ling Tau Chuan , Tey Beng Ti
Published: August 2009

Mechanical and non‐mechanical breakages of bacterial cells are usually the preliminary steps in intracellular protein purification. In this study, the recombinant green fluorescent protein (GFP) was purified from intact Escherichia coli cells using preparative PAGE. In this purification process, cells disruption step is not needed. The cellular content of E. coli was drifted out electrically from cells and the negatively charged GFP was further electroeluted from polyacrylamide gel column. SEM investigation of the electrophoresed cells revealed substantial structural damage at the cellular level. This integrated purification technique has successfully recovered the intracellular GFP with a yield of 82% and purity of 95%.
Numerical study of fast pyrolysis of woody biomass in a gravity‐driven reactor
Authors: Choi Hang Seok , Choi Yeon Seok , Kim Seock Joon
Published: August 2009

In the present study, computational fluid dynamics is applied to investigate fast pyrolysis characteristics of woody biomass in a gravity‐driven reactor. A Eulerian‐Eulerian approach is adopted, including three gas species and three solid phases, for multiphase reacting flow fields between solid and gas. Two‐stage semiglobal reaction kinetics considering the secondary tar cracking mechanism is used for simulation of the pyrolysis reaction. The flow and pyrolysisreaction characteristics of the reactor are investigated, and the reaction rates of woody biomass pyrolysis are evaluated for streamwise locations in the reactor. Also, the inlet condition and inclination angle are changed to study their effects on the reaction. From the predicted results, it is seen that the heat transfer to biomass is governed mainly by mixing of particles, and this influences the final pyrolysis reaction. © 2009 American Institute of Chemical Engineers Environ Prog, 2009
No association between fruit, vegetables, antioxidant nutrients and risk of renal cell carcinoma
Authors: Bertoia Monica , Albanes Demetrius , Mayne Susan T. , Männistö Satu , Virtamo Jarmo , Wright Margaret E.
Published: August 2009

Previous epidemiologic studies that have examined the relationship between renal cell carcinoma (RCC) risk and intakes of plant foods and antioxidant nutrients have yielded inconsistent results. We therefore examined the associations between intakes of fruit, vegetables, carotenoids, flavonoids, vitamin E and vitamin C and RCC risk in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study cohort. At baseline, 27,062 male Finnish smokers aged 50–69 years completed a 276‐item dietary questionnaire that included questions on frequency of consumption and portion size. During up to 19 years of follow‐up, 255 men developed RCC. Cox proportional hazards models were utilized to estimate relative risks (RR) and 95% confidence intervals (CI). Despite a large range in intake, no association was observed between fruit, vegetables or antioxidant nutrients and RCC risk. For example, multivariate RRs and 95% CIs for the highest versus the lowest quartile of intake were 0.79 (0.55–1.14), 1.23 (0.85–1.79), 1.09 (0.74–1.60), 0.83 (0.57–1.21), 1.09 (0.73–1.64) and 0.99 (0.67–1.46) for fruit, vegetables, total carotenoids, total flavonoids, total vitamin E and vitamin C, respectively (all p values for trend > 0.05). Our results indicate that diet may not play a large role in the etiology of RCC in male smokers, although further examination of these associations in nonsmokers, women and diverse racial populations is warranted.
Antioxidant intake from fruits, vegetables and other sources and risk of non‐Hodgkin's lymphoma: the Iowa Women's Health Study
Authors: Thompson Carrie A. , Habermann Thomas M. , Wang Alice H. , Vierkant Robert A. , Folsom Aaron R. , Ross Julie A. , Cerhan James R.
Published: August 2009

Antioxidant nutrients found in fruits, vegetables and other foods are thought to inhibit carcinogenesis and to influence immune status. We evaluated the association of these factors with risk of non‐Hodgkin's lymphoma (NHL) overall and for diffuse large B‐cell lymphoma (DLBCL) and follicular lymphoma specifically in a prospective cohort of 35,159 Iowa women aged 55–69 years when enrolled at baseline in 1986. Diet was ascertained using a validated semiquantitative food frequency questionnaire. Through 2005, 415 cases of NHL (including 184 DLBCL and 90 follicular) were identified. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox regression, adjusting for age and total energy. The strongest associations of antioxidants with risk of NHL (RR for highest versus lowest quartile;pfor trend) were observed for dietary vitamin C (RR = 0.78;p= 0.044), α‐carotene (RR = 0.71;p= 0.015), proanthocyanidins (RR = 0.70;p= 0.0024) and dietary manganese (RR = 0.62;p= 0.010). There were no associations with multivitamin use or supplemental intake of vitamins C, E, selenium, zinc, copper or manganese. From a food perspective, greater intake of total fruits and vegetables (RR = 0.69;p= 0.011), yellow/orange (RR = 0.72;p= 0.015) and cruciferous (RR = 0.82;p= 0.017) vegetables, broccoli (RR = 0.72;p= 0.018) and apple juice/cider (RR = 0.65;p= 0.026) were associated with lower NHL risk; there were no strong associations for other antioxidant‐rich foods, including whole grains, chocolate, tea or nuts. Overall, these associations were mainly observed for follicular lymphoma and were weaker or not apparent for DLBCL. In conclusion, these results support a role for vegetables, and perhaps fruits and associated antioxidants from food sources, as protective factors against the development of NHL and follicular lymphoma in particular.
A two‐photon europium complex as specific endoplasmic reticulum probe
Authors: Law Ga‐Lai , Wong Ka‐Leung , Man Cornelia Wing‐Yin , Tsao Sai‐Wah , Wong Wing‐Tak
Published: August 2009

Highly emissive europium complexes with specific endoplasmic reticulum localization potential includes several advantages such as fast uptake, long resident lifetime, low dosage requirement, low cytotoxicity and highly emissive two‐photon induced f‐f emission imaging. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)