bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction Parameters for Mining Subsidence Based on Interferometric Synthetic Aperture Radar and Unmanned Aerial Vehicle Collaborative Monitoring
Authors: Zhu Mingfei , Yu Xuexiang , Tan Hao , Xie Shicheng , Yang Xu , Han Yuchen
Published: October 2023

Coal mining induces surface subsidence, making rapid and precise monitoring of this subsidence a key area of current research. To address the limitations of D-InSAR technology in capturing large-gradient deformations in the central subsidence basin and the challenges facing UAVs in accurately monitoring small deformations at the basin’s edge, we propose a method for inverting the expected parameters of surface subsidence by synergistically integrating InSAR and UAV monitoring. We determined the cumulative subsidence of monitoring points along the dip and strike observation line of the Banji 110,801 working face between 10 April 2021 and 28 June 2022, employing D-InSAR and UAV techniques. By leveraging the complementary strengths of both monitoring techniques, we fused the two types of monitoring data and verified the error of the fusion data to be within 10 cm through leveling data verification. Simulation experiments utilizing the probability integration method and the Broyden–Fletcher–Goldfarb–Shanno (BFGS) optimization algorithm confirmed that the 10 cm data source error remains within the required limits for probability integration parameter inversion. Finally, the BFGS algorithm was employed to invert the parameters of the probability integration method based on the fusion data results. Subsequently, these inversion parameters were used to predict the subsidence at the monitoring point and were compared with the level measured data. The results demonstrate that the use of collaborative InSAR and UAV monitoring technology for inverting the expected parameters of surface subsidence in the mining area yields superior results, aligning with the actual patterns of ground surface movement and deformation. This study addresses the global need for unmanned monitoring of mining-related subsidence. It employs InSAR and UAV technologies in a synergistic approach to monitor surface subsidence in mining regions. This approach harnesses the strengths of multiple data sources and presents a novel concept for the unmanned monitoring of surface subsidence in mining areas, contributing to environmental protection efforts.
Development of Smart and Lean Pick-and-Place System Using EfficientDet-Lite for Custom Dataset
Authors: Kee Elven , Chong Jun Jie , Choong Zi Jie , Lau Michael
Published: October 2023

Object detection for a pick-and-place system has been widely acknowledged as a significant research area in the field of computer vision. The integration of AI and machine vision with pick-and-place operations should be made affordable for Small and Medium Enterprises (SMEs) so they can leverage this technology. Therefore, the aim of this study is to develop a smart and lean pick-and-place solution for custom workpieces, which requires minimal computational resources. In this study, we evaluate the effectiveness of illumination and batch size to improve the Average Precision (AP) and detection score of an EfficientDet-Lite model. The addition of 8% optimized bright Alpha3 images results in an increase of 7.5% in AP and a 6.3% increase in F1-score as compared to the control dataset. Using a training batch size of 4, the AP is significantly improved to 66.8% as compared to a batch size of 16 at 57.4%. The detection scores are improved to 80% with a low variance of 1.65 using a uniform 135-angle lamp and 0 illumination level. The pick-and-place solution is validated using Single-Shot Detector (SSD) MobileNet V2 Feature Pyramid Network (FPN) Lite. Our experimental results clearly show that the proposed method has an increase of 5.19% in AP compared to SSD MobileNet V2 FPNLite.
A Resilience Engineering Approach for the Risk Assessment of IT Services
Authors: Fargnoli Mario , Murgianu Luca
Published: October 2023

Nowadays, services related to IT technologies have assumed paramount importance in most sectors, creating complex systems involving different stakeholders. Such systems are subject to unpredictable risks that differ from what is usually expected and cannot be properly managed using traditional risk assessment approaches. Consequently, ensuring their reliability represents a critical task for companies, which need to adopt resilience engineering tools to reduce the occurrence of failures and malfunctions. With this goal in mind, the current study proposes a risk assessment procedure for cloud migration processes that integrates the application of the Functional Resonance Analysis Method (FRAM) with tools aimed at defining specific performance requirements for the suppliers of this service. In particular, the Critical-To-Quality (CTQ) method was used to define the quality drivers of the IT platform customers, while technical standards were applied to define requirements for a security management system, including aspects relevant to the supply chain. Such an approach was verified by means of its application to a real-life case study, which concerns the analysis of the risks inherent to the supply chain related to cloud migration. The results achieved can contribute to augmenting knowledge in the field of IT systems’ risk assessment, providing a base for further research.
Seismogram Rearrangement as a Perspective Basis for Defining New Attributes
Authors: Babić Ranko , Babić Lidija
Published: October 2023

Proper regulative in earthquake risk reduction, hazard assessment, earthquake resistant design and construction of structures, should be under perpetual improvement. They are mainly the result of earthquake study and analysis of post-seismic effects. In this context, a new frame for seismogram analysis is proposed, based on its decomposition into elementary and single (positive and negative) fluctuations (EF/SF). Decomposition enables rearrangement, both providing the frame for defining new attributes, where several main ones are proposed and elaborated in the paper: fan diagram of EFs structural axes; R- or RQ-envelope, formed over positive and over negative peaks of ordered SFs; two forms of difference functions of positive and negative R/RQ-envelopes, as a measure of seismogram’s (a)symmetry, in respect to t-axis; distributions of SFs durations. Several others are in perspective. Analogy between R-envelope and seismogram’s spectrum is considered from the aspects of arranged elements, and asymptotic behavior of these two functional attributes. More objective definition of seismogram duration is proposed, determined by linear regression across the scatter plot of SFs peaks. R-envelope showed itself as an invariant in the seismogram population, and the distribution of SFs durations as well. Results are presented through extensive graphics, backed with mathematical description. Thorough discussion of the concept and results is given.
Influence of Selected Factors on Antioxidant Properties of Chlorogenic Acid and Kaempferol as Well as Their Binary Mixtures
Authors: Olszowy-Tomczyk Małgorzata , Wianowska Dorota
Published: October 2023

Plants are a rich source of substances with antioxidant properties, including high amounts of polyphenolic compounds, as well as other substances that do not necessarily have antioxidant properties. The presented paper concerns the evaluation of the antioxidant properties of polyphenolics and their binary mixtures in the presence of other components of the system that do not exhibit antioxidant properties. Model systems containing chlorogenic acid and kaempferol were used in the experiments, differing not only in the volume of the alcoholic antioxidant solution in the measurement system, but also in temperature, content of water, metal ions and hydrogen ions. The ability to neutralize free radicals in the systems was estimated using the ABTS method. In light of the presented data, the dominant resultant antioxidant effect in the mixture is antagonism. Its value depends not only on the mutual relations of individual compounds, but also on the presence of other components in the tested system, not only antioxidants. The greatest effect on the antioxidant properties was observed for systems containing iron ions, ethanol and in the presence of hydrogen ions. The obtained results indicate an extremely complex nature of the assessment of antioxidant properties, even in seemingly simple measurement systems.
Exploring the Evolutionary Disparities: A Case Study on the Psychophysiological Response to Recreating the Hunter–Gatherer Lifestyle through Physical Activity and Caloric Restriction
Authors: Belinchón-deMiguel Pedro , Ramos-Campo Domingo Jesús , Clemente-Suárez Vicente Javier
Published: October 2023

Physical activity has been instrumental in shaping the human body throughout evolution, but modern sedentary lifestyles and excessive caloric intake have contributed to chronic diseases. This study investigates the potential benefits of recreating the hunter–gatherer lifestyle, involving physical activity and caloric restriction on psychophysiological responses. The aim is to understand the evolutionary disparities between ancestral and modern lifestyles. Two male participants, one fasting and one control, were analyzed during a 4-day walking event without caloric consumption. Psychophysiological parameters such as body mass, cortical arousal, hand-grip strength, lower limb strength, heart rate variability, reaction time, hydration status, blood glucose and lactate levels, urine markers, sleep quality, pain perception, stress levels, and perceived exertion were measured. The fasting participant exhibited higher ratings of perceived exertion, stress, pain, and dehydration. They also experienced poorer sleep quality, higher Creatinkinase levels, greater protein presence in urine, decreased lower limb strength, significant weight loss, and increased lactate values. Heart rate variability did not differ significantly between the fasting and control participants. Recreating the hunter–gatherer lifestyle through physical activity and caloric restriction can have implications for enhancing performance and improving overall health. However, further research is needed to better understand the complex interplay of factors involved in the psychophysiological responses to such interventions.
Diffusion-Denoising Process with Gated U-Net for High-Quality Document Binarization
Authors: Han Sangkwon , Ji Seungbin , Rhee Jongtae
Published: October 2023

The binarization of degraded documents represents a crucial preprocessing task for various document analyses, including optical character recognition and historical document analysis. Various convolutional neural network models and generative models have been used for document binarization. However, these models often struggle to deliver generalized performance on noise types the model has not encountered during training and may have difficulty extracting intricate text strokes. We herein propose a novel approach to address these challenges by introducing the use of the latent diffusion model, a well-known high-quality image-generation model, into the realm of document binarization for the first time. By leveraging an iterative diffusion-denoising process within the latent space, our approach excels at producing high-quality, clean, binarized images and demonstrates excellent generalization using both data distribution and time steps during training. Furthermore, we enhance our model’s ability to preserve text strokes by incorporating a gated U-Net into the backbone network. The gated convolution mechanism allows the model to focus on the text region by combining gating values and features, facilitating the extraction of intricate text strokes. To maximize the effectiveness of our proposed model, we use a combination of the latent diffusion model loss and pixel-level loss, which aligns with the model’s structure. The experimental results on the Handwritten Document Image Binarization Contest and Document Image Binarization Contest benchmark datasets showcase the superior performance of our proposed model compared to existing methods.
Quantification of Microplastics in Plastic-Bottled Chinese Baijiu Using Micro-FTIR in Imaging Mode
Authors: Zhou Xuejun , Wang Qian , Wang Jin , Li Hongyan , Ren Jiefang , Tang Shali
Published: October 2023

Microplastics (MPs) are prevalent in our environment, being present in the air we breathe and in the food we consume. Due to the widespread use of plastic materials in everyday life, the amount of microplastics being released into the biosphere has become increasingly apparent in recent years. This study provides the first documentation of the presence of microplastics in Chinese baijiu, a popular alcoholic beverage in China, bottled in plastic. It is essential to note the significance of this discovery and potential implications for human health. Analysis of samples collected from the Chinese market showed the presence of microplastics in all six Chinese baijiu brands tested. Concentrations ranged from 172 MPs/500 mL to 944 MPs/500 mL with an average concentration of 436 MPs/500 mL. Cellulose and PA accounted for 70.4% and 17.8% of all microplastics detected, respectively. These were the most commonly detected types. Other types of microplastics were also found, including PET, PP, PVC, and PE. PET accounted for 2.7%, PP for 2.2%, PVC for 1.2%, and PE for 0.1% of all microplastics. The possible sources of contamination include raw materials, ambient air, and equipment and vessels that shed microplastics. Therefore, this study emphasizes the requirement for further research to mitigate the potential hazards associated with human exposure to microplastics. Additionally, it presents significant findings on the presence of microplastics in Chinese baijiu sold in plastic bottles.
Nitrification and Denitrification Gene Abundances under Stable Soil Chemical Properties Established by Long-Term Compost Fertilization
Authors: Walitang Denver I. , Kim Kiyoon , Lee Yi , Heo Tae-Young , Sa Tongmin
Published: October 2023

Rice paddies are dynamic areas for microbe-mediated nitrogen cycling and this could be driven by the long-term alteration of paddy soil edaphic factors. The objective of this study is to evaluate the lasting impact of long-term compost fertilization on the soil chemical properties of paddy fields, determining the size of the microbial guilds involved in nitrification and denitrification. Soil sampling was done on paddy fields without fertilizer, with NPK + compost, and with compost application, and the soil chemical properties of the fields were determined from 2018 to 2021. The abundance of genes related to nitrogen cycling was measured using quantitative PCR (qPCR). Annual analyses showed that the studied soils have attained stable, baseline chemical properties with significantly increased phosphorus (P2O5), potassium (K), SOM, and total nitrogen (TN) due to decades of fertilization with NPK + compost and compost. Consequently, the genes related to bacterial amoA, nosZI, and nosZII were significantly increased in Com- and NPKCom-amended soils compared to the NF paddy field. The nirK gene abundance was unaffected after long-term amendment with compost. A positive correlation was found between the archaeal amoA gene abundance and DOC, while SOM and TN were consistently positively correlated with the abundances of bacterial amoA, nosZI, and nosZII genes, in addition to interactions with potassium and DOC. Principal component analysis (PCA) indicated soil variabilities across treatments, where the unfertilized paddy field contained lower SOM and nutrient contents with a characteristic nirK gene abundance. Similar variabilities in terms of the SOM, TN, K, nosZI, and nosZII gene abundances were observed in the Com and NPKCom paddy fields. Long-term amendment with NPK + compost and compost created soil paddy fields with stable soil chemical properties with higher SOM and nutrient contents, which established higher abundances of genes associated with denitrification and nitrification that were observed during the fallow period.
Temporal Instability Analysis of Injury Severities for Angle and Non-Angle Crashes at Roundabouts
Authors: Li Ye , Ge Chang , Chen Qinghong , Yuan Chen , Xing Lu
Published: October 2023

Roundabout crashes are common worldwide but have received little attention. In particular, the investigation remains relatively understudied in distinct collision modes of roundabout crashes, including angle and non-angle crashes. This study investigates differences in factors affecting injury severity between angle and non-angle crashes and how these differences change over time. Random parameter logit models with heterogeneity in mean and variance were estimated using 2012–2019 Florida crash data. Variables considered for the modeling include temporal characteristics, environmental characteristics, road characteristics, spatial characteristics, vehicle characteristics, crash characteristics, and human characteristics. In addition, likelihood ratio tests were used to investigate the temporal instabilities of the models and differences in collision modes. The results showed that only a few variables demonstrated temporally stable effects for angle collisions (weekend and dark-lighted) and non-angle collisions (paved shoulders and cyclists), respectively. Unique influencing factors of injury severity were identified for different collision modes, such as dark-lighted, straight alignment, merge, lane departure, the disabled driver for angle collisions, and clear, fog, commercial vehicles, and aggressive driving for non-angle collisions. The results of the out-of-sample prediction simulations further demonstrate the difference in injury severity over time for angle and non-angle collisions. Overall results suggest that countermeasures can be implemented to reduce the injury severity of angle crashes/non-angle crashes based on the significant variables identified. This study may be used to improve roundabout safety by considering different collision modes.
Assessing the Influence Factors of Agricultural Soils’ CH4/N2O Emissions Based on the Revised EDGAR Datasets over Hainan Island in China
Authors: Song Jiayu , Wei Jun , Zhou Wenming , Zhang Jie , Liu Wenjie , Zhang Feixiang , Zhou Haiyan
Published: October 2023

Global warming poses a significant environmental challenge, which is primarily driven by the increase in greenhouse gas concentrations. In this study, we aimed to investigate the factors influencing CH4/N2O emissions from agricultural soils over Hainan Island, China, from 2009 to 2018. To achieve this, we selected air temperature, precipitation, and solar radiation as climate factors and categorized farmland as paddy or non-paddy, using revised EDGAR greenhouse gas datasets involving the bias correction method, and geographical detector analysis, multiple linear regression models, and bias sensitivity analysis were used to quantify the sensitivity of climate and land use. The maximum air temperature emerged as the primary factor influencing CH4 emissions, while the mean air temperature predominantly affected N2O emissions. The ratio of paddy field area to city area emerged as the second most influential factor impacting CH4/N2O emissions. The mean CH4/N2O emission intensity from paddy fields was significantly higher (0.42 t·hm−2/0.0068 t·hm−2) compared to that of non-paddy fields (0.04 t·hm−2/0.002 t·hm−2). Changes in maximum air temperature under global warming and crop irrigation practices profoundly affect greenhouse gas emissions on Hainan Island. Specifically, the emission intensities of CH4 and N2O increased by 14.2% and 11.14% for each Kelvin warmer, respectively.
Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium–Mitochondrial Axis Invoked by Magnetic Field Exposure
Authors: Franco-Obregón Alfredo
Published: October 2023

Mitohormesis is a process whereby mitochondrial stress responses, mediated by reactive oxygen species (ROS), act cumulatively to either instill survival adaptations (low ROS levels) or to produce cell damage (high ROS levels). The mitohormetic nature of extremely low-frequency electromagnetic field (ELF-EMF) exposure thus makes it susceptible to extraneous influences that also impinge on mitochondrial ROS production and contribute to the collective response. Consequently, magnetic stimulation paradigms are prone to experimental variability depending on diverse circumstances. The failure, or inability, to control for these factors has contributed to the existing discrepancies between published reports and in the interpretations made from the results generated therein. Confounding environmental factors include ambient magnetic fields, temperature, the mechanical environment, and the conventional use of aminoglycoside antibiotics. Biological factors include cell type and seeding density as well as the developmental, inflammatory, or senescence statuses of cells that depend on the prior handling of the experimental sample. Technological aspects include magnetic field directionality, uniformity, amplitude, and duration of exposure. All these factors will exhibit manifestations at the level of ROS production that will culminate as a unified cellular response in conjunction with magnetic exposure. Fortunately, many of these factors are under the control of the experimenter. This review will focus on delineating areas requiring technical and biological harmonization to assist in the designing of therapeutic strategies with more clearly defined and better predicted outcomes and to improve the mechanistic interpretation of the generated data, rather than on precise applications. This review will also explore the underlying mechanistic similarities between magnetic field exposure and other forms of biophysical stimuli, such as mechanical stimuli, that mutually induce elevations in intracellular calcium and ROS as a prerequisite for biological outcome. These forms of biophysical stimuli commonly invoke the activity of transient receptor potential cation channel classes, such as TRPC1.
Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies
Authors: Montoya-Durango Diego , Walter Mary Nancy , Rodriguez Walter , Wang Yali , Chariker Julia H. , Rouchka Eric C. , Maldonado Claudio , Barve Shirish , McClain Craig J. , Gobejishvili Leila
Published: October 2023

Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes, hepatic stellate cells, and cellular components of hepatic sinusoids. Importantly, it has been shown that cAMP levels and enzymes involved in cAMP homeostasis are affected by alcohol. Although the role of cyclic nucleotide signaling is strongly implicated in several pathological pathways in liver diseases, studies describing the changes in genes regulating cyclic nucleotide metabolism in ALD are lacking. Methods: Male C57B/6 mice were used in an intragastric model of alcohol-associated steatohepatitis (ASH). Liver injury, inflammation, and fibrogenesis were evaluated by measuring plasma levels of injury markers, liver tissue cytokines, and gene expression analyses. Liver transcriptome analysis was performed to examine the effects of alcohol on regulators of cyclic AMP and GMP levels and signaling. cAMP and cGMP levels were measured in mouse livers as well as in livers from healthy human donors and patients with alcohol-associated hepatitis (AH). Results: Our results show significant changes in several phosphodiesterases (PDEs) with specificity to degrade cAMP (Pde4a, Pde4d, and Pde8a) and cGMP (Pde5a, Pde6d, and Pde9a), as well as dual-specificity PDEs (Pde1a and Pde10a) in ASH mouse livers. Adenylyl cyclases (ACs) 7 and 9, which are responsible for cAMP generation, were also affected by alcohol. Importantly, adenosine receptor 1, which has been implicated in the pathogenesis of liver diseases, was significantly increased by alcohol. Adrenoceptors 1 and 3 (Adrb), which couple with stimulatory G protein to regulate cAMP and cGMP signaling, were significantly decreased. Additionally, beta arrestin 2, which interacts with cAMP-specific PDE4D to desensitize G-protein-coupled receptor to generate cAMP, was significantly increased by alcohol. Notably, we observed that cAMP levels are much higher than cGMP levels in the livers of humans and mice; however, alcohol affected them differently. Specifically, cGMP levels were higher in patients with AH and ASH mice livers compared with controls. As expected, these changes in liver cyclic nucleotide signaling were associated with increased inflammation, steatosis, apoptosis, and fibrogenesis. Conclusions: These data strongly implicate dysregulated cAMP and cGMP signaling in the pathogenesis of ASH. Future studies to identify changes in these regulators in a cell-specific manner could lead to the development of novel targeted therapies for ASH.
Zebrafish Models of Rare Neurological Diseases like Spinocerebellar Ataxias (SCAs): Advantages and Limitations
Authors: Sarasamma Sreeja , Karim Anwarul , Orengo James P.
Published: October 2023

Spinocerebellar ataxia (SCA) is a heterogeneous group of rare familial neurodegenerative disorders that share the key feature of cerebellar ataxia. Clinical heterogeneity, diverse gene mutations and complex neuropathology pose significant challenges for developing effective disease-modifying therapies in SCAs. Without a deep understanding of the molecular mechanisms involved for each SCA, we cannot succeed in developing targeted therapies. Animal models are our best tool to address these issues and several have been generated to study the pathological conditions of SCAs. Among them, zebrafish (Danio rerio) models are emerging as a powerful tool for in vivo study of SCAs, as well as rapid drug screens. In this review, we will summarize recent progress in using zebrafish to study the pathology of SCAs. We will discuss recent advancements on how zebrafish models can further clarify underlying genetic, neuroanatomical, and behavioral pathogenic mechanisms of disease. We highlight their usefulness in rapid drug discovery and large screens. Finally, we will discuss the advantages and limitations of this in vivo model to develop tailored therapeutic strategies for SCA.
Interindividual Brain and Behavior Differences in Adaptation to Unexpected Uncertainty
Authors: Soussi Célia , Berthoz Sylvie , Chirokoff Valentine , Chanraud Sandra
Published: October 2023

To adapt to a new environment, individuals must alternate between exploiting previously learned “action–consequence” combinations and exploring new actions for which the consequences are unknown: they face an exploration/exploitation trade-off. The neural substrates of these behaviors and the factors that may relate to the interindividual variability in their expression remain overlooked, in particular when considering neural connectivity patterns. Here, to trigger environmental uncertainty, false feedbacks were introduced in the second phase of an associative learning task. Indices reflecting exploitation and cost of uncertainty were computed. Changes in the intrinsic connectivity were determined using resting-state functional connectivity (rFC) analyses before and after performing the “cheated” phase of the task in the MRI. We explored their links with behavioral and psychological factors. Dispersion in the participants’ cost of uncertainty was used to categorize two groups. These groups showed different patterns of rFC changes. Moreover, in the overall sample, exploitation was correlated with rFC changes between (1) the anterior cingulate cortex and the cerebellum region 3, and (2) the left frontal inferior gyrus (orbital part) and the right frontal inferior gyrus (triangular part). Anxiety and doubt about action propensity were weakly correlated with some rFC changes. These results demonstrate that the exploration/exploitation trade-off involves the modulation of cortico-cerebellar intrinsic connectivity.
DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases
Authors: Klonisch Thomas , Logue Susan E. , Hombach-Klonisch Sabine , Vriend Jerry
Published: October 2023

The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1, E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational modification (PTM) to proteins. Ubiquitination can alter protein functions and/or mark ubiquitinated proteins for proteasomal degradation but deubiquitinases (DUBs) can reverse protein ubiquitination. While the importance of DUBs as regulatory factors in the UPS is undisputed, many questions remain on DUB selectivity for protein targeting, their mechanism of action, and the impact of DUBs on the regulation of diverse biological processes. Furthermore, little is known about the expression and role of DUBs in tumors of the human central nervous system (CNS). In this comprehensive review, we have used publicly available transcriptional datasets to determine the gene expression profiles of 99 deubiquitinases (DUBs) from five major DUB families in seven primary pediatric and adult CNS tumor entities. Our analysis identified selected DUBs as potential new functional players and biomarkers with prognostic value in specific subtypes of primary CNS tumors. Collectively, our analysis highlights an emerging role for DUBs in regulating CNS tumor cell biology and offers a rationale for future therapeutic targeting of DUBs in CNS tumors.
Theta and Gamma Activity Differences in Obsessive–Compulsive Disorder and Panic Disorder: Insights from Resting-State EEG with eLORETA
Authors: Lee Ilju , Kim Kyoung Min , Lim Myung Ho
Published: October 2023

Background: Obsessive–compulsive disorder (OCD) and panic disorder (PD) are debilitating psychiatric conditions, yet their underlying neurobiological differences remain underexplored. This study aimed to directly compare resting-state EEGs in patients with OCD and PD, without a healthy control group, using the eLORETA method. Methods: We collected retrospective EEG data from 24 OCD patients and 22 PD patients who were hospitalized due to significant impairment in daily life functions. eLORETA was used to analyze the EEG data. Results: Heightened theta activity was observed in the anterior cingulate cortex (ACC) of OCD patients compared to PD patients (PD vs. OCD, t = −2.168, p < 0.05). Conversely, higher gamma activity was found in the medial frontal gyrus (MFG) and paracentral lobule (PCL) in PD patients (PD vs. OCD, t = 2.173, p < 0.05). Conclusions: Our findings highlight neurobiological differences between OCD and PD patients. Specifically, the increased theta activity in the ACC for OCD patients and elevated gamma activity in the MFG and PCL for PD patients offer preliminary insights into the neural mechanisms of these disorders. Further studies are essential to validate these results and delve deeper into the neural underpinnings.
Daytime-Restricted Feeding Ameliorates Oxidative Stress by Increasing NRF2 Transcriptional Factor in the Rat Hippocampus in the Pilocarpine-Induced Acute Seizure Model
Authors: Mercado-Gómez Octavio Fabián , Arriaga-Ávila Virginia Selene , Vega-García Angélica , Orozco-Suarez Sandra , Pérez-Koldenkova Vadim , Camarillo-Sánchez Juan José , Álvarez-Herrera Marcelino , Guevara-Guzmán Rosalinda
Published: October 2023

Seizure-mediated oxidative stress is a crucial mechanism in the pathophysiology of epilepsy. This study evaluated the antioxidant effects of daytime-restricted feeding (DRF) and the role of the Nrf2 signaling pathway in a lithium-pilocarpine model seizure model that induces status epilepticus (SE). We performed a lipoperoxidation assay and dihydroethidium fluorescence to measure oxidative stress markers in the hippocampus (malondialdehyde and reactive oxygen species). The protein content of Nrf2 and its downstream protein SOD2 was evaluated using Western blotting. The cellular distribution of the Nrf2 and SOD2 proteins in the pyramidal cell layer of both the CA1 and CA3 hippocampal subfields and astrocytes (GFAP marker) were quantified using immunofluorescence and immunohistochemistry, respectively. Our results indicate that DRF reduced the malondialdehyde levels and the production of reactive oxygen species. Furthermore, a significant increase in Nrf2 and SOD2 protein content was observed in animals subjected to restrictive diet. In addition, DRF increased the relative intensity of the Nrf2 fluorescence in the perinuclear and nuclear compartments of pyramidal neurons in the CA1 subfield. Nrf2 immunoreactivity and the astrocyte marker GFAP also increased their colocalization under DRF conditions. Additionally, SOD2 immunoreactivity was increased in CA1 pyramidal neurons but not in the CA3 region. Our findings suggest that DRF partially prevents oxidative stress by increasing the Nrf2 transcriptional factor and the SOD2 enzyme during the development of SE.
Chopped Straw as an Insulation Material: The Influence of Different Blow-In Technologies and Flame Retardants on Hygrothermal Properties
Authors: Salonen Tarja , Fischer Henriette , Korjenic Azra
Published: October 2023

The demand for renewable resources in building construction is increasing, and wheat straw is an excellent option due to its superior environmental performance compared to traditional insulation materials. However, the hygrothermal properties of chopped wheat straw insulation have remained largely unexplored. At the moment, blown-in straw is only blown in vertically, although horizontal blowing would be more efficient depending on the situation. This study investigates the effect of different blowing techniques on the thermal properties of chopped wheat straw insulation, focusing on the difference between vertical and horizontal blowing techniques. In-situ-measured thermal conductivities were compared with design values used in energy balances. In addition, the long-term hygrothermal behavior of chopped wheat straw insulation treated with flame retardants was investigated. The methodology included heat flow plate measurements, needle probe measurements and laboratory measurements using the hot plate method. The results show that there is no significant difference in thermal performance between the blowing techniques. The measured thermal conductivities were lower than expected, challenging the current general normative moisture surcharge on the thermal conductivity of natural fiber insulation. The addition of the flame retardant had no noticeable effect on the hygrothermal properties of the chopped straw. Chopped wheat straw can be regarded as a highly ecological insulation material with great potential for the future.
The Influence of Different Shear Directions on the Shear Resistance Characteristics of Rock Joints
Authors: Lai Xipeng , Yuan Wei , Wang Wei , Sun Ruifeng , Du Pengzhao , Lin Hang , Fu Xiaodong , Niu Qinghe , Yin Chao
Published: October 2023

The joint roughness coefficient JRC of rock joints is an important parameter for measuring the geometric morphology of rock joints. However, the parameter obtained from traditional calculation methods has certain limitations in reflecting the differences in shear strength of rock joints in different shear directions with the same orientation. Firstly, native joint surface test blocks were cast using three-dimensional reverse reconstruction technology. Subsequently, direct shear tests were conducted under different normal stress and shear direction conditions, followed by numerical simulations using the finite difference software Flac3d. The JRC coefficient calculation method proposed by Yuan was modified and extended by considering the percentage of climbing sections and the effective contact area during the ramping process. This study indicates that the numerical simulation results are in good agreement with the shear test results. The introduction of the shear climbing rate SCR and the curvature coefficient of profile CCP is used to reflect the geometric differences of the joint surfaces in different shear directions. These two parameters are nonlinearly fitted with the experimental results, leading to a calculation formula that characterizes the shear strength characteristics of the joint surfaces in different shear directions. This novel formula is an extension of the JRC–JCS model.
Influence of Doorway Position on Wind Comfort in Beijing Quadrangle Dwellings
Authors: Wang Zefa , Liu Tingfeng , Wu Xiaogang , Chen Jing , Liang Xujun
Published: October 2023

During the Qing Dynasty and Republic of China, Three Essentials of Dwelling was a much-sought-after approach for the design of quadrangle dwellings, with the primary focus being on the positioning of the doorways. By employing vector data of typical quadrangle dwellings in Beijing to construct an ideal model that complies with the Three Essentials of Dwelling setting, this study aims to investigate the impact of the doorway position on the wind comfort of quadrangle dwellings through CFD (Computational Fluid Dynamics) simulation, by comparing and analyzing the wind comfort of quadrangle courtyards with different doorway position layouts. The results are as follows: (1) Placing doors in the windward position during the season can make a significant difference in the courtyard wind comfort of quadrangle dwellings. (2) Compared to the direction of the doorway, the position of the doorway significantly affects the wind comfort of the courtyard in a quadrangle dwelling. (3) Keeping the position of the doorway constant, adjusting the height of the main room can be a successful strategy to improve the wind comfort of the courtyard in a quadrangle dwelling. (4) There is no link between environmental quality assessment and wind environmental quality assessment in Three Essentials of Dwelling. This study proves that the positioning of doorways can optimize the wind comfort in quadrangle dwellings, demonstrating the ancient Chinese’s ecological acumen in the layout of quadrangle houses, and providing useful guidance to designers.
The Relevance of the Low-Frequency Sound Insulation of Window Elements of Façades on the Perception of Urban-Type Sounds
Authors: de la Prida Daniel , Navacerrada María Ángeles , Aguado-Yáñez María , Azpicueta-Ruiz Luis Antonio , Pedrero Antonio , Caballol David
Published: October 2023

The sound insulation of the façade and its elements is a very important characteristic, as it largely determines the degree of sound protection of the building’s interior from external noise sources. This feature, therefore, has a great influence on the acoustic comfort and health of the occupants. For this reason, it is very important that the way in which the sound insulation of the façade is quantified and represented corresponds to the way it is perceived. Although there have long been regulations describing how it should be measured and expressed through Single-Number Quantities (SNQs), there is much scientific debate about the appropriateness of current standardised methods for expressing sound insulation, in terms of whether they accurately represent human-perceived comfort. In this regard, much of the debate centres on the frequency range to be considered when expressing sound insulation, with no consensus as to whether the low-frequency bands (i.e., 50, 63, and 80 Hz) should be used for the calculation of façade sound insulation SNQs. In order to contribute to this knowledge, we conducted a listening test using a Two-Alternative Choice (2-AC) protocol on a sample of 100 participants to test whether participants’ annoyance with urban noise changed significantly with variations in window sound insulation only in the low-frequency range. The results of the experiment, analysed using Thurstonian models, showed that the influence of low frequencies is limited for the sound insulation of the tested window façade elements and urban-type noise of aircraft and mixed urban traffic at low speeds and only becomes relevant when the sound insulation of the elements is exceptionally low in the low-frequency range.
Impact of Daylighting on Visual Comfort and on the Biological Clock for Teleworkers in Residential Buildings
Authors: Acosta Ignacio , Campano Miguel Ángel , Bellia Laura , Fragliasso Francesca , Diglio Francesca , Bustamante Pedro
Published: October 2023

The current socio-economic scenario has promoted telecommuting at home for a significant number of workers, mainly due to the sanitary situation experienced and the improvement in communication technologies. However, the work context at home is often not suitable for teleworking since the environmental conditions are not usually adequate for good performance and the wellness of workers. The received light, both in quantity and in spectrum, affects the visual comfort and performance of the worker through the regulation of the circadian stimulus. Accordingly, the objective of the present study is to ascertain the influence of natural daylight on the performance and health of teleworkers, considering a room at home analyzed in three different locations, two orientations, two-time schedules, and two window shapes. The impact of natural light on health was assessed using the Circadian Stimulus Autonomy (CSA) produced by daylight during the morning, while the illuminance requirement was defined in accordance with the Daylight Autonomy (DA). The results obtained were contrasted with a real test cell under real daylight conditions. The conclusions of this study serve to determine the suitable windowed areas of the analyzed room where teleworkers obtain the appropriate lighting performance and well-being.
Radiomics Analysis in Characterization of Salivary Gland Tumors on MRI: A Systematic Review
Authors: Mao Kaijing , Wong Lun M. , Zhang Rongli , So Tiffany Y. , Shan Zhiyi , Hung Kuo Feng , Ai Qi Yong H.
Published: October 2023

Radiomics analysis can potentially characterize salivary gland tumors (SGTs) on magnetic resonance imaging (MRI). The procedures for radiomics analysis were various, and no consistent performances were reported. This review evaluated the methodologies and performances of studies using radiomics analysis to characterize SGTs on MRI. We systematically reviewed studies published until July 2023, which employed radiomics analysis to characterize SGTs on MRI. In total, 14 of 98 studies were eligible. Each study examined 23–334 benign and 8–56 malignant SGTs. Least absolute shrinkage and selection operator (LASSO) was the most common feature selection method (in eight studies). Eleven studies confirmed the stability of selected features using cross-validation or bootstrap. Nine classifiers were used to build models that achieved area under the curves (AUCs) of 0.74 to 1.00 for characterizing benign and malignant SGTs and 0.80 to 0.96 for characterizing pleomorphic adenomas and Warthin’s tumors. Performances were validated using cross-validation, internal, and external datasets in four, six, and two studies, respectively. No single feature consistently appeared in the final models across the studies. No standardized procedure was used for radiomics analysis in characterizing SGTs on MRIs, and various models were proposed. The need for a standard procedure for radiomics analysis is emphasized.
Electrochemical Synthesis of Versatile Pyrimidine and Oxadiazoles Tethered Triazoles as Inhibitors of VEGFR-2 in Human Breast Cancer Cells
Authors: Ravish Akshay , Siddappa Tejaswini P. , Xi Zhang , Vishwanath Divakar , Mohan Arunkumar , Basappa Shreeja , Krishnamurthy Niranjan Pattehalli , Lobie Peter E. , Pandey Vijay , Basappa Basappa
Published: October 2023

Metastasis, the dissemination of tumor cells, stands as the second most prominent contributor to mortality arising from breast cancer. To counteract this phenomenon, the molecular markers associated with angiogenesis, particularly vascular endothelial growth factor (VEGF) and its receptor (VEGFR), have emerged as promising strategies for impeding the progression of tumor cells. Compounds like pyrimidines, coumarins, oxadiazoles, and triazoles have undergone comprehensive investigations due to their notable anticancer potential, highlighting their encouraging capacities in inhibiting VEGFR-2, an essential mediator of angiogenesis signaling. Herein, we have synthesized pyrimidine–triazoles and oxadiazole–triazoles using electrochemical and conventional methods. The newly synthesized compounds were evaluated for anticancer activity against MCF-7 breast cancer cells, and it was found that the compounds 8a and 8b showed IC50 values of 5.29 and 15.54 μM, respectively. Our in silico mode of action revealed that these compounds could target VEGFR-2, which was further evidenced by our in silico structure-based bioinformatic analysis. In conclusion, we reported an electrochemical method to prepare novel drug-like compounds, based on triazole and other heterocyclic hybrids, that could be used to design VGFR-targeting drugs.
Special Issue on “Advanced Catalytic Material for Water Treatment”
Authors: Du Jiangkun , Yang Lie , Qi Chengdu
Published: October 2023

Water is the source of life on Earth [...]
Hydrogen Gas Generation Using Self-Assembled Monolayers (SAMs) of 5,10,15,20-Tetrakis (p-Thiophenol) Porphyrin on a Gold Electrode
Authors: Elghamry Ibrahim , Alablan Abdulrahman S. , Abdelsalam Mamdouh E.
Published: October 2023

A novel approach was used to synthesize the 5,10,15,20-tetrakis (p-thiophenol) porphyrin (TPTH-P) (2), which involved the demethylation of tetra (p-anisole) porphyrin (1) in the presence of ZnCl2 as a catalyst and DMF as a solvent at 100 °C. The demethylation step was followed by an acidification step with concentrated H2SO4 to yield the desired TPTH-P (2) in an almost quantitative yield (95%). The chemical structure of the synthesized porphyrin thiol (TPTH-P) (2) was verified through spectroscopic techniques (NMR, IR, UV-Vis). The catalytic activity of TPTH-P in the hydrogen evolution reaction (HER) was investigated in 0.1 M of H2SO4 and 1 M of KNO3. A self-assembled monolayer (SAM) of TPTH-P was formed on a gold electrode. The immersion time during SAM formation and the electrochemical activation cycles in H2SO4 were found to be important to enhancing the activity of the Au-TPTH-P electrode in the HER. Contact angle measurements and electrochemical techniques, including cyclic voltammetry (CV), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), and chronoamperometry, were used to characterize and evaluate the electrochemical activities of the SAM.
Removal of Taste and Odor Compounds from Water: Methods, Mechanism and Prospects
Authors: Wang Feng , Li Xiaohui , Liu Tingting , Li Xiang , Cui Yi , Xu Ling , Huo Shuhao , Zou Bin , Qian Jingya , Ma Anzhou , Zhuang Guoqiang
Published: October 2023

In recent years, taste and odor (T&O) compounds in drinking water are becoming a serious problem, which has brought many challenges to drinking water treatment plants. Due to global concerns about the emergence of T&O compounds, researchers have proposed various water treatment technologies to ensure the quality of drinking water. In this paper, abiotic and biotic methods for the treatment of T&O compounds are reviewed, including process parameters, advantages and disadvantages, removal efficiency and mechanism. Geosmin (GSM) and 2-methylisoborneol (2-MIB) are the most common odorous substances with earthy and musty smells. The chemical and biological methods for the possible degradation pathways of these two compounds are summarized. Furthermore, suggestions and approaches are provided for efficient and safe strategies for T&O compound treatments and their future applications.