bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological Properties of Calcium Phosphate Bioactive Glass Composite Bone Substitutes: Current Experimental Evidence
Authors: Karadjian Maria , Essers Christopher , Tsitlakidis Stefanos , Reible Bruno , Moghaddam Arash , Boccaccini Aldo R. , Westhauser Fabian
Published: January 2019

Standard treatment for bone defects is the biological reconstruction using autologous bone—a therapeutical approach that suffers from limitations such as the restricted amount of bone available for harvesting and the necessity for an additional intervention that is potentially followed by donor-site complications. Therefore, synthetic bone substitutes have been developed in order to reduce or even replace the usage of autologous bone as grafting material. This structured review focuses on the question whether calcium phosphates (CaPs) and bioactive glasses (BGs), both established bone substitute materials, show improved properties when combined in CaP/BG composites. It therefore summarizes the most recent experimental data in order to provide a better understanding of the biological properties in general and the osteogenic properties in particular of CaP/BG composite bone substitute materials. As a result, BGs seem to be beneficial for the osteogenic differentiation of precursor cell populations in-vitro when added to CaPs. Furthermore, the presence of BG supports integration of CaP/BG composites into bone in-vivo and enhances bone formation under certain circumstances.
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis
Authors: Schneider Kai Markus , Mohs Antje , Kilic Konrad , Candels Lena Susanna , Elfers Carsten , Bennek Eveline , Schneider Lukas Ben , Heymann Felix , Gassler Nikolaus , Penders John , Trautwein Christian
Published: January 2019

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in western countries, with a continuously rising incidence. Gut-liver communication and microbiota composition have been identified as critical drivers of the NAFLD progression. Hence, it has been shown that microbiota depletion can ameliorate high-fat diet or western-diet induced experimental Non-alcoholic steatohepatitis (NASH). However, its functional implications in the methionine-choline dietary model, remain incompletely understood. Here, we investigated the physiological relevance of gut microbiota in methionine-choline deficient (MCD) diet induced NASH. Experimental liver disease was induced by 8 weeks of MCD feeding in wild-type (WT) mice, either with or without commensal microbiota depletion, by continuous broad-spectrum antibiotic (AB) treatment. MCD diet induced steatohepatitis was accompanied by a reduced gut microbiota diversity, indicating intestinal dysbiosis. MCD treatment prompted macroscopic shortening of the intestine, as well as intestinal villi in histology. However, gut microbiota composition of MCD-treated mice, neither resembled human NASH, nor did it augment the intestinal barrier integrity or intestinal inflammation. In the MCD model, AB treatment resulted in increased steatohepatitis activity, compared to microbiota proficient control mice. This phenotype was driven by pronounced neutrophil infiltration, while AB treatment only slightly increased monocyte-derived macrophages (MoMF) abundance. Our data demonstrated the differential role of gut microbiota, during steatohepatitis development. In the context of MCD induced steatohepatitis, commensal microbiota was found to be hepatoprotective.
p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions
Authors: Lee Mee-Hyun , Kundu Joydeb Kumar , Choi Bu Young
Published: January 2019

The hYSK1, a serine/threonine kinase (STK)-25, has been implicated in a variety of cellular functions including cell migration and polarity. We have recently reported that hYSK1 down-regulated the expression and functions of p16INK4a, a cell cycle regulatory protein, thereby enhancing migration and growth of cancer cells under hypoxic conditions. In this study, we further investigated the mechanisms underlying downregulation of p16INK4a and anti-migratory function of hYSK1. Our study revealed that p21WAF1/Cip1 is a novel binding partner of hYSK1. Moreover, the interaction between hYSK1 and p21WAF1/Cip1 led to the inhibition of SP-1 transcriptional activity, as revealed by a significant down-regulation of SP-1-mediated transactivation of p16INK4a promoter, and accelerated MMP-2 expression. Conversely, the knock-down of hYSK1 enhanced the p16INK4a promoter activity and protein expression, and diminished MMP-2 transcription and protein levels in hypoxic conditions as compared to control. Taken together, hYSK1 blocks the p21WAF1/Cip1 functions by direct interaction and inhibits the p16INK4a expression and induces MMP-2 expression by its regulations of SP-1 transcriptional activity under the hypoxia conditions.
A Novel Dipeptidyl Peptidase IV Inhibitory Tea Peptide Improves Pancreatic β-Cell Function and Reduces α-Cell Proliferation in Streptozotocin-Induced Diabetic Mice
Authors: Lu Yating , Lu Peng , Wang Yu , Fang Xiaodong , Wu Jianming , Wang Xiaochang
Published: January 2019

Dipeptidyl peptidase IV (DPP-IV) inhibitors occupy a growing place in the drugs used for the management of type 2 diabetes. Recently, food components, including food-derived bioactive peptides, have been suggested as sources of DPP-IV inhibitors without side effects. Chinese black tea is a traditional health beverage, and it was used for finding DPP-IV inhibitory peptides in this study. The ultra-filtrated fractions isolated from the aqueous extracts of black tea revealed DPP-IV inhibitory activity in vitro. Four peptides under 1 kDa were identified by SDS-PAGE and LC-MS/MS (Liquid Chromatography-Mass Spectrometry-Mass Spectrometry) from the ultra-filtrate. The peptide II (sequence: AGFAGDDAPR), with a molecular mass of 976 Da, showed the greatest DPP-IV inhibitory activity (in vitro) among the four peptides. After administration of peptide II (400 mg/day) for 57 days to streptozotocin (STZ)-induced hyperglycemic mice, the concentration of glucagon-like peptide-1 (GLP-1) in the blood increased from 9.85 ± 1.96 pmol/L to 19.22 ± 6.79 pmol/L, and the insulin level was increased 4.3-fold compared to that in STZ control mice. Immunohistochemistry revealed the improved function of pancreatic beta-cells and suppressed proliferation of pancreatic alpha-cells. This study provides new insight into the use of black tea as a potential resource of food-derived DPP-IV inhibitory peptides for the management of type 2 diabetes.
The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview
Authors: Wang Dongdong , Atanasov Atanas G.
Published: January 2019

Vascular smooth muscle cell (VSMC) proliferation plays a critical role in atherosclerosis. At the beginning of the pathologic process of atherosclerosis, irregular VSMC proliferation promotes plaque formation, but in advanced plaques VSMCs are beneficial, promoting the stability and preventing rupture of the fibrous cap. Recent studies have demonstrated that microRNAs (miRNAs) expressed in the vascular system are involved in the control of VSMC proliferation. This review summarizes recent findings on the miRNAs in the regulation of VSMC proliferation, including miRNAs that exhibit the inhibition or promotion of VSMC proliferation, and their targets mediating the regulation of VSMC proliferation. Up to now, most of the studies were performed only in cultured VSMC. While the modulation of miRNAs is emerging as a promising strategy for the regulation of VSMC proliferation, most of the effects of miRNAs and their targets in vivo require further investigation.
Forecasting Issues of Wireless Communication Networks’ Cyber Resilience for An Intelligent Transportation System: An Overview of Cyber Attacks
Authors: Buinevich Mikhail , Vladyko Andrei
Published: January 2019

During the last decade there has been an essential development of wireless communication technologies for intelligent transportation system (ITS) applications for motor transport; these advanced infocommunication technologies are called vehicular ad hoc networks (VANET). VANET/ITS, in particular, inform and warn drivers about possible obstacles, and also the possibility of how to organize coordinated actions. Therefore, any violation of its functioning by cyber attacks automatically influences the safety of people and automotive engineering on the road. The purpose of this article is to provide an analytical overview of cyber attacks on VANET/ITS, presented in state-of-the-art publications on this topic by the prediction of its cyber resistance. We start with an analysis of the top 10 cyber threats, considered according to the following schemes: attack mechanism, vulnerability, damage, object of attack, and a counter measure. We then set out a synergistic approach for assessing the cyber resistance of the forward-looking VANET/ITS conceptual model, formed by the merger of the internet of vehicles and software-defined networking technology. Finally, we identify open issues and associated research opportunities, the main ones being the formalization of threats, vulnerability stratification, the choice of the level of network management centralization and, last but not least, the modeling and prediction of VANET/ITS cyber resistance.
Designing and Evaluating a Virtual Patient Simulation—The Journey from Uniprofessional to Interprofessional Learning
Authors: Martini Nataly , Farmer Kate , Patil Shambhavi , Tan Gauis , Wang Cindy , Wong Lucy , Webster Craig S.
Published: January 2019

“Ready to Practice?”(R2P) is a virtual patient simulation designed for undergraduate medical and pharmacy students. After initial prototyping, R2P developed into a screen-based virtual patient (VP) simulation with an intuitive interface using photorealistic images of people and places with speech bubbles and decision menus. We describe the design of the VP, findings from student experiences with the software, and the potential of VPs for interprofessional learning. We used a mixed methods study to assess students’ perceptions of the VP as a learning tool. Qualitative data were gathered using semi-structured interviews and observations, and quantitative data through the Readiness for Interprofessional Learning Scale (RIPLS) and an evaluation questionnaire. Overall, participants showed significantly improved RIPLS scores after participation in the simulation (78.78 to 82.25, p < 0.0001), including in the Positive Professional Identify domain (p < 0.001). Students also showed significant improvement in RIPLS scores in the Teamwork and Collaboration domain when pharmacy and medical students were working together in interprofessional pairs (40.75 to 43.00, p < 0.006) but not when working alone (n.s.). Five themes emerged from interviews where participants identified specific interprofessional insights into each other’s roles and skills. Students found the VP engaging and valuable for their learning and their understanding of teamwork.
Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables
Authors: Castellano-Castillo Daniel , Moreno-Indias Isabel , Sanchez-Alcoholado Lidia , Ramos-Molina Bruno , Alcaide-Torres Juan , Morcillo Sonsoles , Ocaña-Wilhelmi Luis , Tinahones Francisco , Queipo-Ortuño María Isabel , Cardona Fernando
Published: January 2019

Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic homeostasis, and AT dysfunction has an active role in metabolic diseases. MetS is closely related to lifestyle and environmental factors. Epigenetics has emerged as an interesting landscape to evaluate the possible interconnection between AT and metabolic disease, since it can be modulated by environmental factors and metabolic status. The aim of this study was to determine whether MetS has an impact on the global DNA methylation pattern and the DNA methylation of several genes related to adipogenesis (PPARG, PPARA), lipid metabolism (RXRA, SREBF2, SREBF1, SCD, LPL, LXRb), and inflammation (LRP1 C3, LEP and TNF) in visceral adipose tissue. LPL and TNF DNA methylation values were significantly different in the control-case comparisons, with higher and lower methylation respectively in the MetS group. Negative correlations were found between global DNA methylation (measured by LINE-1 methylation levels) and the metabolic deterioration and glucose levels. There were associations among variables of MetS, BMI, and HOMA-IR with DNA methylation at several CpG positions for the studied genes. In particular, there was a strong positive association between serum triglyceride levels (TG) with PPARA and LPL methylation levels. TNF methylation was negatively associated with the metabolic worsening and could be an important factor in preventing MetS occurrence according to logistic regression analysis. Therefore, global DNA methylation and methylation at specific genes related to adipogenesis, lipid metabolism and inflammation are related to the etiology of MetS and might explain in part some of the features associated to metabolic disorders.
Prediction of Orthotropic Hygroscopic Swelling of Fiber-Reinforced Composites from Isotropic Swelling of Matrix Polymer
Authors: Krauklis Andrey E. , Gagani Abedin I. , Echtermeyer Andreas T.
Published: January 2019

Swelling in fiber-reinforced composites is anisotropic. In this work, dealing with glass fiber epoxy composite immersed in distilled water, swelling coefficients are obtained in each direction experimentally. Swelling behaviour in the fiber direction was constrained by the non-swelling fibers and was close to null, while swelling in the transverse directions was found to occur freely—similar to the unconstrained polymer. An analytical method for predicting anisotropic swelling in composites from the swelling of the matrix polymer is reported in this work. The method has an advantage that it is simple to use in practice and requires only a swelling coefficient of the matrix polymer, elastic constants of the matrix and fibers, and a known fiber volume fraction of the composite. The method was validated using finite element analysis. Good agreement was obtained and is reported between experimental hygroscopic swelling data, analytical and numerical results for composite laminates, indicating the validity of this predictive approach.
Efficiency of Vegetables Produced in Glasshouses: The Impact of Data Envelopment Analysis (DEA) in Land Management Decision Making
Authors: Bournaris Thomas , Vlontzos George , Moulogianni Christina
Published: January 2019

Glasshouse farming is one of the most intensive types of production of agricultural products. Via this process, consumers have the ability to consume mainly off-season vegetables and farmers are able to reduce operational risks, due to their ability to control micro-climate conditions. This type of farming is quite competitive worldwide, this being the main reason for formulating and implementing assessment models measuring operational performance. The methodology used in this study is Data Envelopment Analysis (DEA), which has wide acceptance in agriculture, among other sectors of the economy. The production protocols of four different vegetables—cucumber, eggplant, pepper, and tomato—were evaluated. Acreage (m2), crop protection costs (€), fertilizers (€), labor (Hr/year), energy (€), and other costs (€) were used as inputs. The turnover of every production unit (€) was used as the output. Ninety-eight agricultural holdings participated in this survey. The dataset was obtained by face-to-face interviews. The main findings verify the existence of significant relative deficiencies (including a mean efficiency score of 0.87) as regards inputs usage, as well as considerably different efficiency scores among the different cultivations. The most efficient of these was the eggplant production protocol and the least efficient was that used for the tomato. The implementation of DEA verified its utility, providing incentives for continuing to use this methodology for improving land management decision making.
The Influence of a Piston Ring Coating on the Wear and Friction Generated during Linear Oscillation
Authors: Rozario Arthur , Baumann Christoph , Shah Raj
Published: January 2019

The piston group is responsible for contributing to ~50% of the frictional losses of an engine, which ultimately leads to the waste of fuel. This coupled with the fact that gasoline is a finite resource linked to CO2-emissions, there is an increased demand of higher performance vehicles, which coincidently further loads the piston ring. As of yet, there are plenty of studies that already study the piston ring’s contact with the cylinder liner. However, this study focuses on a cost-effective Schwing, Reib, Verschleiss (SRV) instrumentation that allows to pre-screen lubricants, additives, materials and coatings for their friction, wear and load carrying capacity including scuffing resistance. As a result of the pre-screening conducted outside of engine by using the SRV instrument, it brings us to the following conclusion: the PVD CrN-TiN 1º Group coating on the piston ring produces the least wear, as well as the lowest coefficient of friction. Moreover, it is concluded that a coating that is based from CrN and TiN allows the piston ring to perform better in engine settings. A continued understanding of the piston-cylinder-contact assembly only helps engineers, scientists and any other stakeholder to improve on the piston ring and cylinder liner interaction.
Effect of Moisture on Shape Memory Polyurethane Polymers for Extrusion-Based Additive Manufacturing
Authors: Garces Irina T. , Aslanzadeh Samira , Boluk Yaman , Ayranci Cagri
Published: January 2019

Extrusion-based additive manufacturing (EBAM) or 3D printing is used to produce customized prototyped parts. The majority of the polymers used with EBAM show moisture sensitivity. However, moisture effects become more pronounced in polymers used for critical applications, such as biomedical stents, sensors, and actuators. The effects of moisture on the manufacturing process and the long-term performance of Shape Memory Polyurethane (SMPU) have not been fully investigated in the literature. This study focuses primarily on block-copolymer SMPUs that have two different hard/soft (h/s) segment ratios. It investigates the effect of moisture on the various properties via studying: (i) the effect of moisture trapping within these polymers and the consequences when manufacturing; (ii) and the effect on end product performance of plasticization by moisture. Results indicate that higher h/s SMPU shows higher microphase separation, which leads to an increase of moisture trapping within the polymer. Understanding moisture trapping is critical for EBAM parts due to an increase in void content and a decrease in printing quality. The results also indicate a stronger plasticizing effect on polymers with lower h/s ratio but with a more forgiving printing behavior compared to the higher h/s ratio.
Digital Image Correlation Comparison of Damaged and Undamaged Aeronautical CFRPs During Compression Tests
Authors: Barile Claudia , Casavola Caterina , Pappalettera Giovanni
Published: January 2019

The diffusion of composite materials in aeronautical and aerospace applications is attributable to the high specific mechanical properties they offer. In particular, the recent use of Carbon Fiber Reinforced Polymer (CFRP) materials is highly increased. The main disadvantage in using this kind of material is related to the possibility of including damages or defects not visible on the surface that compromise their behavior and make their use extremely unsafe if not properly supervised. The most conventional nondestructive techniques allow the detection of damages when they already compromise the life of these materials. The use of the same techniques makes it harder to monitor in-situ of the progress of damages, especially if they occur inside the materials. The implementation of the innovative strain analysis method, like those based on full-field measurements, could provide additional information about the damage mechanisms by supplying the complete strain distribution of the surface of the sample. The present paper examines the mechanical behavior of two different CFRP specimens, with and without damage, subjected to compressive load in an anti-buckling fixture by using the Digital Image Correlation (DIC). The purpose is to measure the out-of-plane displacements, characteristics of the compression tests, in all the points of the ROI (Region of Interest), using a full-field and noncontact technique. The innovative aspect of this work is therefore to solve this problem through an experimental approach with DIC 3D technique.
Synthesis and Characterization of K and Eu Binary Phosphides
Authors: Dolyniuk Juli-Anna , Mark Justin , Lee Shannon , Tran Nhon , Kovnir Kirill
Published: January 2019

The synthesis, structural characterization, and optical properties of the binary Zintl phases of α-EuP3, β-EuP3, EuP2, and α-K4P6 are reported in this study. These crystal structures demonstrate the versatility of P fragments with dimensionality varying from 0D (P6 rings in α-K4P6) to 1D chains (EuP2) to 2D layers (both EuP3). EuP2 is isostructural to previously reported SrP2 and BaP2 compounds. The thermal stabilities of the EuP2 and both EuP3 phases were determined using differential scanning calorimetry (DSC), with melting temperatures of 1086 K for the diphosphide and 1143 K for the triphosphides. Diffuse reflectance spectroscopy indicated that EuP2 is an indirect semiconductor with a direct bandgap of 1.12(5) eV and a smaller indirect one, less than 1 eV. Both EuP3 compounds had bandgaps smaller than 1 eV.
Size-Dependent and Multi-Field Coupling Behavior of Layered Multiferroic Nanocomposites
Authors: Shi Yang , Wang Yongkun
Published: January 2019

The prediction of magnetoelectric (ME) coupling in nano-scaled multiferroic composites is significant for nano-devices. In this paper, we propose a nonlinear multi-field coupling model for ME effect in layered multiferroic nanocomposites based on the surface stress model, strain gradient theory and nonlinear magneto-elastic-thermal coupling constitutive relation. With this novel model, the influence of external fields on strain gradient and flexoelectricity is discussed for the first time. Meanwhile, a comprehensive investigation on the influence of size-dependent parameters and multi-field conditions on ME performance is made. The numerical results show that ME coupling is remarkably size-dependent as the thickness of the composites reduces to nanoscale. Especially, the ME coefficient is enhanced by either surface effect or flexoelectricity. The strain gradient in composites at the nano-scale is significant and influenced by the external stimuli at different levels via the change in materials’ properties. More importantly, due to the nonlinear multi-field coupling behavior of ferromagnetic materials, appropriate compressive stress and temperature may improve the value of ME coefficient and reduce the required magnetic field. This paper provides a theoretical basis to analyze and evaluate multi-field coupling characteristics of nanostructure-based ME devices.
Contact Lens Materials: A Materials Science Perspective
Authors: Musgrave Christopher Stephen Andrew , Fang Fengzhou
Published: January 2019

More is demanded from ophthalmic treatments using contact lenses, which are currently used by over 125 million people around the world. Improving the material of contact lenses (CLs) is a now rapidly evolving discipline. These materials are developing alongside the advances made in related biomaterials for applications such as drug delivery. Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. This review provides an advanced perspective on contact lens materials, with an emphasis on materials science employed in developing new CLs. The future trends for CL materials are to graft, incapsulate, or modify the classic CL material structure to provide new or improved functionality. In this paper, we discuss some of the fundamental material properties, present an outlook from related emerging biomaterials, and provide viewpoints of precision manufacturing in CL development.
Bipolar Disorder and Comorbid Borderline Personality Disorder: Patient Characteristics and Outcomes in US Hospitals
Authors: Patel Rikinkumar S. , Manikkara Geetha , Chopra Amit
Published: January 2019

Background and objectives: The quality of life and disease outcomes in bipolar patients, including increased risk of psychiatric hospitalizations and suicide, are adversely affected by the presence of borderline personality disorder (BPD). Our study aims to determine the impact of BPD on the inpatient outcomes of bipolar disorder patients. Methods: We used Nationwide Inpatient Sample from the US hospitals and identified cases with bipolar disorder and comorbid BPD (N = 268,232) and controls with bipolar disorder only (N = 242,379), using the International Classification of Diseases, 9th Revision, and Clinical Modification codes. We used multinomial logistic regression to generate odds ratios (OR) and evaluate inpatient outcomes. Results: The majority of the bipolar patients with BPD were female (84.2%), Caucasian (83.1%) and 18–35 years age (53.9%). Significantly longer inpatient stays, higher inpatient charges, and higher prevalence of drug abuse were noted in bipolar patients with BPD. The suicide risk was higher in bipolar patients with BPD (OR = 1.418; 95% CI 1.384–1.454; p < 0.001). In addition, utilization of electroconvulsive treatment (ECT) was higher in bipolar patients with comorbid BPD (OR = 1.442; 95% CI 1.373–1.515; p < 0.001). Conclusions: The presence of comorbid BPD in bipolar disorder is associated with higher acute inpatient care due to a longer inpatient stay and higher cost during hospitalization, and higher suicide risk, and utilization of ECT. Further studies in the inpatient setting are warranted to develop effective clinical strategies for optimal outcomes and reduction of suicide risk in bipolar patients with BPD.
Influence of Stress on Kinetics and Transformation Plasticity of Ferrite Transformation Based on Hysteresis Effects
Authors: Ding Wenhong , Liu Yazheng , Xie Jianxin , Sun Li , Liu Tianwu
Published: January 2019

Transformation plasticity and kinetics play an essential role in the prediction of residual stresses resulting from transformation. This paper is devoted to the investigation of the influence of stress on the kinetics and transformation plasticity of ferrite for H420LA steel. It has been shown that under small external stresses, lower than the yield stress of the weaker phase, the ferrite transformation is inhibited at the beginning of the transformation in the continuous cooling process and the mechanical stabilization of austenite is observed, due to transformation hysteresis effects. This phenomenon affects the metallurgical and mechanical behaviors of the transformation progress. However, most existing models ignore these effects, leading to deviations in the description of transformation plasticity during the transformation progress. Considering the hysteresis effects, the micromechanical model for kinetics and transformation plasticity is reexamined. A general formulation of austenite decomposition kinetics accounting for these effects is developed to better describe the phase transformation under a continuous cooling process. In addition, the influence of hysteresis effects on the evolution of transformation plasticity is analyzed. Consideration of the hysteresis effects decreases the discrepancy between the calculated and experimental values. This will allow better prediction of residual stresses in the thermomechanically controlled processes.
Effect of Temperature Scheme on Microstructure and Mechanical Properties during Medium Carbon Steel Warm Processing
Authors: Li Hong-Bin , Fan Lifeng , Chen Lian-Sheng
Published: January 2019

Influence of temperature scheme on the microstructure and properties variation of medium carbon steel warm deformation was studied with testing equipment of Gleeble-3500, SEM, TEM, EBSD, and φ350 reversal rolling mill. The results show that the temperature of 650 facilitates the formation of ultrafine homogeneous microstructure. The microstructure formed during temperature range of 650–700 °C is relative homogeneous and fine. The mechanical properties of warm rolling are influenced by the cooling modes. The lower cooling rate is benefit to the combination of strength and ductility.
Modification of Mechanical Properties of High-Strength Titanium Alloys VT23 and VT23M Due to Impact-Oscillatory Loading
Authors: Chausov Mykola , Brezinová Janette , Pylypenko Andrii , Maruschak Pavlo , Titova Liudmyla , Guzanová Anna
Published: January 2019

A simple technological method is proposed and tested experimentally, which allows for the improvement of mechanical properties in sheet two-phase high-strength titanium alloys VT23 and VT23M on the finished product (rolled metal), due to impact-oscillatory loading. Under impact-oscillatory loading and dynamic non-equilibrium processes (DNP) are realized in titanium alloys, leading to the self-organization of the structure. As a result, the mechanical properties of titanium alloys vary significantly with subsequent loading after the realization of DNP. In this study, the test modes are found, which can be used in the production conditions.
Bioleaching for Copper Extraction of Marginal Ores from the Brazilian Amazon Region
Authors: Nascimento Dryelle Nazaré Oliveira do , Lucheta Adriano Reis , Palmieri Maurício César , Carmo Andre Luiz Vilaça do , Silva Patricia Magalhães Pereira , Ferreira Rafael Vicente de Pádua , Junca Eduardo , Grillo Felipe Fardin , Alves Joner Oliveira
Published: January 2019

The use of biotechnology to explore low-grade ore deposits and mining tailings is one of the most promising alternatives to reduce environmental impacts and costs of copper extraction. However, such technology still depends on improvements to be fully applied in Brazil under industrial scale. In this way, the bioleaching, by Acidithiobacillus ferrooxidans, in columns and stirred reactors were evaluated regarding to copper extraction of a mineral sulfide and a weathered ore from the Brazilian Amazon region. Samples (granulometry of 2.0/4.75 mm) were characterized by X-ray diffraction (XRD), energy dispersive X-ray fluorescence (EDXRF) spectrometry and scanning electrons microscopy (SEM). The pH and Oxidation-reduction potential (Eh) were daily monitored and leachate samples were collected for copper extraction determination by EDXRF. After 47 days, the columns bioleaching efficiency was 1% (1298 mg Cu·L−1) and 0.95% (985 mg Cu·L−1) for 2.00/4.75 mm sulfide ore, respectively, whereas the stirred reactors bioleaching resulted in 4% (348 mg Cu·L−1) for the mineral sulfide and 47% (295.5 mg Cu·L−1) for the weathered ore.
Microstructure and Properties of Porous Titanium Prepared by Spark Plasma Sintering
Authors: Liu Shifeng , Zhang Guangxi , Shi Mingjun , Yang Xin , Li An
Published: January 2019

Porous titanium samples with a porosity of 1.34~15.54% were prepared by a spark plasma sintering (SPS) process at sintering temperatures of 800 °C, 850 °C and 900 °C, and a sintering pressure of 10 MPa. The microstructures and fracture morphology of the samples were investigated by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses. The compressive strength and elastic modulus were likewise measured. The results showed that no new phase occurred after the samples were sintered, and the main phases were α phase of hcp structure. The porosity of the samples decreased significantly with the increase of sintering temperature. At 800 °C, the sample phase was dominated by equiaxed α. There were more irregular coarse pores in the samples. At 850 °C, the microstructure was mainly zigzag α, and the pores were finely and relatively uniform in distribution. At 900 °C, the sample’s structure transformed into a dense sheet-like α. The sample’s densities increased and the pores disappeared. The room temperature compression test showed that the porous titanium sintered by SPS had excellent compressive strength. The yield strength, compressive strength, compressive strain and elastic modulus were 81.85~122.36 MPa, 161.65~498.86 MPa, 36.75~59.97% and 2.79~4.22 GPa, respectively.
Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population
Authors: Lu Yonghai , Wang Yeli , Liang Xu , Zou Li , Ong Choon Nam , Yuan Jian-Min , Koh Woon-Puay , Pan An
Published: January 2019

We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population.
Implementation of a CMOS/MEMS Accelerometer with ASIC Processes
Authors: Liu Yu-Sian , Wen Kuei-Ann
Published: January 2019

This paper presents the design, simulation and mechanical characterization of a newly proposed complementary metal-oxide semiconductor (CMOS)/micro-electromechanical system (MEMS) accelerometer. The monolithic CMOS/MEMS accelerometer was fabricated using the 0.18 μm application-specific integrated circuit (ASIC)-compatible CMOS/MEMS process. An approximate analytical model for the spring design is presented. The experiments showed that the resonant frequency of the proposed tri-axis accelerometer was around 5.35 kHz for out-plane vibration. The tri-axis accelerometer had an area of 1096 μm × 1256 μm.
Role of Oral Microbiota in Cancer Development
Authors: Karpiński Tomasz M.
Published: January 2019

Nowadays cancer is the second main cause of death in the world. The most known bacterial carcinogen is Helicobacter pylori. Pathogens that can have an impact on cancer development in the gastrointestinal tract are also found in the oral cavity. Some specific species have been identified that correlate strongly with oral cancer, such as Streptococcus sp., Peptostreptococcus sp., Prevotella sp., Fusobacterium sp., Porphyromonas gingivalis, and Capnocytophaga gingivalis. Many works have also shown that the oral periopathogens Fusobacterium nucleatum and Porphyromonas gingivalis play an important role in the development of colorectal and pancreatic cancer. Three mechanisms of action have been suggested in regard to the role of oral microbiota in the pathogenesis of cancer. The first is bacterial stimulation of chronic inflammation. Inflammatory mediators produced in this process cause or facilitate cell proliferation, mutagenesis, oncogene activation, and angiogenesis. The second mechanism attributed to bacteria that may influence the pathogenesis of cancers by affecting cell proliferation is the activation of NF-κB and inhibition of cellular apoptosis. In the third mechanism, bacteria produce some substances that act in a carcinogenic manner. This review presents potentially oncogenic oral bacteria and possible mechanisms of their action on the carcinogenesis of human cells.
Behavior of Tin and Antimony in Secondary Copper Smelting Process
Authors: Klemettinen Lassi , Avarmaa Katri , O’Brien Hugh , Taskinen Pekka , Jokilaakso Ari
Published: January 2019

Different types of metal-bearing wastes, such as WEEE (Waste Electrical and Electronic Equipment), are important urban minerals in modern society, and the efficient recycling and reuse of their metal values is of key interest. Pyrometallurgical copper smelting is one of the most prominent ways of treating WEEE, however, more accurate experimental data is needed regarding the behavior of different elements during each process stage. This article investigates the behavior of tin and antimony, both commonly present as trace elements in electrical and electronic waste, in secondary (i.e., sulfur-free) copper smelting conditions. The experiments were conducted in oxygen partial pressure range of 10−10–10−5 atm, covering the different process steps in copper smelting. The basis of the equilibrium system was metallic copper–iron silicate slag, with the addition of alumina and potassium oxide to account for the presence of these compounds in the actual industrial process. The results showed that the distribution coefficients of both trace metals, LCu/slag = [wt % Me]copper/(wt % Me)slag, increased significantly as a function of decreasing oxygen pressure, and the addition of basic potassium oxide also had an increasing effect on the distribution coefficient. A brief comparison between EPMA and LA-ICP-MS (electron probe microanalysis and laser ablation–inductively coupled plasma–mass spectrometry), the two in situ analytical techniques used, was also presented and discussed.
Selective Separation of Scheelite from Calcite by Self-Assembly of H2SiO3 Polymer Using Al3+ in Pb-BHA Flotation
Authors: Wei Zhao , Hu Yuehua , Han Haisheng , Sun Wei , Wang Ruolin , Sun Wenjuan , Wang Jianjun , Gao Zhiyong , Wang Li , Zhang Chenyang , Sun Lei , Liu Ruohua
Published: January 2019

The flotation separation of scheelite from calcite is problematic, where sodium silicate modified by polyvalent metal ions has shown some advantages for selective depression. In this study, an Al-Na2SiO3 polymer was used as the depressant for the flotation separation of scheelite from calcite using a lead complex of benzohydroxamic acid (Pb-BHA) as the collector. Furthermore, a number of measurements were conducted to investigate the structure of the Al-Na2SiO3 polymer and its adsorption behavior with Pb-BHA complexes on the mineral surface. Flotation experiments indicated that the Al-Na2SiO3 polymer shows good selectivity for the flotation separation of scheelite from calcite at pH 8, where the optimum ratio of sodium silicate to aluminum sulfate was 2:1. Fourier-Transform Infrared (FTIR) and solution chemical analyses revealed that aluminum hydroxide complexes and the hydroxy moiety of silicic acid are able to self-assemble via condensation affording an Al-Na2SiO3 polymer, i.e., a composite aluminosilicate polymer. The zeta potential measurements and adsorption capacity measurements indicated that, upon adsorption of the Al-Na2SiO3 polymer and Pb-BHA complexes on the mineral surface, the Al-Na2SiO3 polymer had less influence on the adsorption of Pb-BHA complexes on the scheelite surface, while the opposite was true for calcite. Therefore, more Pb-BHA complexes and fewer Al-Na2SiO3 polymers were deposited on the scheelite surface, while fewer Pb-BHA complexes and more Al-Na2SiO3 polymers were adsorbed on the calcite surface. The selective separation of scheelite from calcite was attributed to the cooperative selectivity of the Pb-BHA complexes and Al-Na2SiO3 polymer.
Influence of High Conductive Magnetite Impurity on the Electrical Conductivity of Dry Olivine Aggregates at High Temperature and High Pressure
Authors: Dai Lidong , Hu Haiying , Sun Wenqing , Li Heping , Liu Changcai , Wang Mengqi
Published: January 2019

The electrical conductivity of dry sintered olivine aggregates with various contents of magnetite (0, 3, 5, 7, 10, 20, and 100 vol. %) was measured at temperatures of 873–1273 K and a pressure of 2.0 GPa within a frequency range of 0.1–106 Hz. The changes of the electrical conductivity of the samples with temperature followed an Arrhenius relation. The electrical conductivity of the sintered olivine aggregates increased as the magnetite-bearing content increased, and the activation enthalpy decreased, accordingly. When the content of interconnected magnetite was higher than the percolation threshold (~5 vol. %), the electrical conductivity of the samples was markedly enhanced. As the pressure increased from 1.0 to 3.0 GPa, the electrical conductivity of the magnetite-free olivine aggregates decreased, whereas the electrical conductivity of the 5 vol. % magnetite-bearing sample increased. Furthermore, the activation energy and activation volume of the 5 vol. % magnetite-bearing sintered olivine aggregates at atmospheric pressure were calculated to be 0.16 ± 0.04 eV and −1.50 ± 0.04 cm3/mole respectively. Due to the high value of percolation threshold (~5 vol. %) in the magnetite impurity sample, our present results suggest that regional high conductivity anomalies in the deep Earth’s interior cannot be explained by the presence of the interconnected magnetite-bearing olivine aggregates.
Formation and Alterations of the Potentially Harmful Maillard Reaction Products during the Production and Storage of Brown Fermented Milk
Authors: Han Zhonghui , Gao Jianxin , Wang Xiaomin , Wang Wenxiang , Dong Jing , Zhang Yan , Wang Shuo
Published: January 2019

To improve the quality and safety of brown fermented milk (BFM), the formation and alterations of potentially harmful Maillard reaction products (MRPs), including 3-deoxyglucosone (3-DG), methylglyoxal (MGO), 5-(hydroxymethyl)-2-furfural (HMF), acrylamide and flavour components were investigated during the browning, fermentation and commercial storage. MRPs were shown to be produced mainly during the browning stage. The levels of different substances varied during the fermentation and commercial storage stage. The proportion and type of carboxylic acids in the flavour components significantly increased during the fermentation stage. Browning index of milk during the browning stage was shown to be positively associated with the 3-DG (Pearson’s r = 0.9632), MGO (Pearson’s r = 0.9915), HMF (Pearson’s r = 0.9772), and acrylamide (Pearson’s r = 0.7910) levels and the total percentage of the flavour components from four different categories (Pearson’s r = 0.7407). Changes in physicochemical properties of BFM during production not only contribute to predict the formation of potentially unhealthy MRPs, but also Lactobacillus species used for the fermentation should be carefully selected to improve the quality of this product.
5-Hydroxymethylfurfural Mitigates Lipopolysaccharide-Stimulated Inflammation via Suppression of MAPK, NF-κB and mTOR Activation in RAW 264.7 Cells
Authors: Kong Fanhui , Lee Bae Hoon , Wei Kun
Published: January 2019

5-Hydroxymethylfurfural (5-HMF) is found in many food products including honey, dried fruits, coffee and black garlic extracts. Here, we investigated the anti-inflammatory activity of 5-HMF and its underlying mechanisms in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. 5-HMF pretreatment ranging from 31.5 to 126.0 μg/mL reduced the production of nitric oxide (NO), prostaglandin E2 (PGE2) and pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in a concentration-dependent manner in LPS-stimulated cells. Moreover, 5-HMF-pretreated cells significantly down-regulated the mRNA expression of two major inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and suppressed the production of pro-inflammatory cytokines, as compared with the only LPS-stimulated cells. 5-HMF suppressed the phosphorylation of extracellular regulated protein kinases (ERK1/2), c-Jun N-terminal kinase (JNK), IκBα, NF-κB p65, the mammalian target of rapamycin (mTOR) and protein kinase B (Akt). Besides, 5-HMF was proved to inhibit NF-κB p65 translocation into nucleus to activate inflammatory gene transcription. These results suggest that 5-HMF could exert the anti-inflammatory activity in the LPS-induced inflammatory response by inhibiting the MAPK, NF-κB and Akt/mTOR pathways. Thus, 5-HMF could be considered as a therapeutic ingredient in functional foods.
Anti-Arthritis Effect through the Anti-Inflammatory Effect of Sargassum muticum Extract in Collagen-Induced Arthritic (CIA) Mice
Authors: Jeon Hyelin , Yoon Weon-Jong , Ham Young-Min , Yoon Seon-A , Kang Se Chan
Published: January 2019

(1) Background: Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage and functional loss. It is characterized by synovial inflammation that leads to progressive cartilage destruction. For this reason, research on functional foods that reduce the inflammatory response are under progress. (2) Methods: We focused on the anti-inflammatory effects of Sargassum muticum, and confirmed the effect of the extract on the collagen-induced arthritis (CIA) DBA/1J mice model. (3) Results: The extract was given at concentrations of 50, 100, and 200 mg/kg, and the arthritis score and edema volume of the experimental group were significantly different from the CIA group. The level of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were determined in serum and lymphocytes. The expression of these cytokines in the serum remarkably decreased from S. muticum extract (SME)100 mg/kg, and decreased from SME 200 mg/kg in lymphocytes. Also, immunohistochemical analysis of IL-6 and TNF-α in the joints revealed that the inflammatory response was noticeably lower when treated with S. muticum extract. (4) Conclusions: This study provides results of the experiment of S. muticum extract treatment in a mouse model. The treatment was found to contribute to the alleviation of edema and symptoms by reducing the expression of inflammatory cytokines. It was concluded that it may be a useful substance to help in the mitigation of arthritis symptoms.
Alcyonacea: A Potential Source for Production of Nitrogen-Containing Metabolites
Authors: Alarif Walied Mohamed , Abdel-Lateff Ahmed , Alorfi Hajer Saeed , Alburae Najla Ali
Published: January 2019

Alcyonacea (soft corals and gorgonia) are well known for their production of a wide array of unprecedented architecture of bioactive metabolites. This diversity of compounds reported from Alcyonacea confirms its productivity as a source of drug leads and, consequently, indicates requirement of further chemo-biological investigation. This review can be considered a roadmap to investigate the Alcyonacea, particularly those produce nitrogen-containing metabolites. It covers the era from the beginning of marine nitrogen-containing terpenoids isolation from Alcyonacea up to December 2018. One hundred twenty-one compounds with nitrogenous moiety are published from fifteen genera. Their prominent biological activity is evident in their antiproliferative effect, which makes them interesting as potential leads for antitumor agents. For instance, eleutherobin and sarcodictyins are in preclinical or clinical stages.