bluuebunny/crossref_metadata_2025 huggingface dataset:
Cost Difference in Performing Total Knee Arthroplasty at Ambulatory Surgical Centers Compared With Hospital-Based Outpatient Departments: Observational Study
Authors: Kim Tommy , Nin Darren , Chen Ya-Wen , Chang David C. , Talmo Carl T. , Hollenbeck Brian L. , Niu Ruijia , Mattingly David A. , Smith Eric L.
Published: June 2024

Background:

As total knee arthroplasty (TKA) further transitions toward an outpatient procedure, it becomes important to identify the resource utilization after TKAs at different outpatient facilities. The objective of this study was to determine the 90-day cost of patients who underwent TKAs at an ambulatory surgical center (ASC) or a hospital outpatient department (HOPD).

Methods:

An observational cohort study was conducted using the Marketscan database with patients who had a TKA at an ASC or HOPD between January 1st, 2019, and October 2nd, 2021. The primary outcome was cost in a 90-day period (including the day of surgery), with inpatient admissions and ED visits as secondary outcomes. Multivariable regression analyses were conducted, adjusting for patient characteristics.

Results:

The study population consisted of 47,261 patients with 7,874 ASC patients and 39,387 HOPD patients. 90-day costs for ASC patients were lower compared with HOPD patients ($35,634 ± 19,030 vs. $38,096 ± 24,389, P < 0.001). 90-day inpatient admission rates were lower for ASC than HOPD patients (2.5% vs. 4.8%, P < 0.001). 90-day ED visits for ASC patients were lesser compared with HOPD patients (8.9% vs. 12.7%, P < 0.001).

Conclusion:

Patients with TKAs at an ASC had an overall lower cost, inpatient admissions, and ED visits over a 90-day period compared with HOPD patients. Future consideration for which outpatient facilities patients have their TKA at is necessary as TKAs shift toward bundle payments and outpatient procedures.
Hospital de la Hermandad del Refugio
Authors: Martín José María , Ramos Díaz Francisco
Published: June 2024

La historia de los hospitales empieza escribir con la historia de la Iglesia que, movida por su celo de atención al necesitado, va estableciendo lugares donde son acogidos y atendidos en sus penurias, particularmente las causadas por la enfermedad con sus secuelas, no solamente promovidos por eclesiástico, sino por las diferentes agrupaciones de laicos que surgen en su seno, como son las cofradías, hermandades, esclavitudes, etc. que no la había sin su hospital para atender a los miembros de la misma, sin que faltaran otras abiertas a terceros. Este es caso del que nos ocupamos, el des hospital de San Antonio de los Alemanes, conocido también por el nombre de la Hermandad que lo administraba, la de Nuestra Señora del Refugio y Piedad de Madrid.
Huellas de la Merced en Toro: Edad Media y Moderna
Authors: Ruiz barrera María Teresa
Published: June 2024

El propósito de estas páginas obedece al deseo de reunir algunos datos — inéditos en parte —, que esbocen retazos de la historia mercedaria en tierras zamoranas. Presente la Merced desde el siglo XIII al siglo XIX, y la rama descalza desde el siglo XVII hasta nuestros días, por desgracia el transcurso de las centurias y las diversas circunstancias históricas han hecho desaparecer o mermar, en algunos casos, su patrimonio en la antigua y hermosa ciudad de Toro.
PROPOSIÇÕES DE MODELOS MATEMÁTICOS PARA O PROBLEMA DE SEQUENCIAMENTO EM PROJETOS COM RESTRIÇÃO DE RECURSOS E ANÁLISE DE DESEMPENHO
Authors: Vieira Clarisse da Silva , Rola Fernanda Silva Cerceau
Published: June 2024

A otimização no sequenciamento das atividades e na alocação dos recursos é uma área de grande interesse no meio do gerenciamento de projetos para criar vantagens competitivas, aumentando a eficiência produtiva das empresas. Assim, várias formulações matemáticas já foram propostas para tentar solucionar problemas desse tipo. Dessa forma, esta pesquisa apresenta proposições de Modelos Matemáticos para o Problema de Sequenciamento em Projetos com Restrição de Recursos (PSPRR). Três modelos de Programação Linear Inteira Mista serão considerados como método de solução para três casos distintos. Esses modelos serão implementados nos programas GLPK e CPLEX e a partir das soluções obtidas, serão feitas comparações entre eles, considerando os parâmetros de tempo e memória. Será observado, também, o desempenho do programa utilizado de acordo com, o aumento da complexidade dos modelos matemáticos, bem como dos dados utilizados, para a obtenção da solução ótima. Assim, a escolha adequada do modelo matemático e do programa computacional torna-se uma ferramenta relevante no processo de tomada de decisão.
Tax Avoidance Determinants of Earning Management
Authors: Siska  , Nursida Nina , Astuti Eni Dwi
Published: June 2024

This research seeks to empirically explore the impact of Other Comprehensive Income, Financial Distress, Tax Avoidance, and Free Cash Flow on Earnings Management among Real Estate and Property firms listed on the Indonesia Stock Exchange during the period spanning 2019 to 2021. Employing a approach quantitative, the research utilizes multiple linear regression analysis conducted through SPSS 26 as the analytical tool. Through purposive sampling from a total population of 60 companies, 43 entities meeting the specified criteria were chosen as the sample. The findings reveal that while Other Comprehensive Income, Financial Distress, and Free Cash Flow do not exert a significant influence on earnings management, tax avoidance emerges as a notable factor impacting earnings management.
Sustainable Tourism Development Strategy Through the Community-Based Tourism Model at DTW Pesona Leuweung Oko, Cirapuhan Village, Garut District
Authors: Kurniadinata Widya , Suhartini Ninik
Published: June 2024

Community-based tourism (CBT) is very important for tourism growth, especially to support the economy of communities around tourist destination areas (DTW). Garut Regency, with its natural resources, culture and natural beauty, has great potential in this region. However, the growth of the tourism sector must be adjusted to the principles of sustainability and consider the prosperity of local communities. CBT is a tourism development approach that involves local communities to actively participate in planning, managing and benefiting from the tourism industry. This gives communities the opportunity to control the progress of tourism in their region. In Cirapuhan, especially in DTW Leuweung Oko, the process of developing Tourism Villages faces challenges. During the development process of the Leuweung Oko DTW, there was a disagreement between the developer and the surrounding community because this instrument was needed to look deeper at the source of the problem, using this qualitative descriptive method to explain tourism conditions clearly. The results of this research are problems that occur between tourism actors in Pesona Leuweung OKO, causing losses for each actor.
The Role of Policies Made by the Government Towards Empowering Local Communities
Authors: Achmad Willya
Published: June 2024

Empowering local communities is an important aspect in the sustainable development of a country. This research aims to analyze the role of policies that have been made by the Government in the context of empowering local communities. Through a qualitative approach and case studies, this research will explore the implementation and impact of these policies on increasing the capacity, participation and welfare of local communities. The research results highlight the role of government policy clusters in empowering local communities, which involves providing resources, access to education, and creating a supportive environment. Although the cluster had a significant positive impact in increasing the economic independence and quality of life of local communities, challenges related to slow bureaucracy, corruption and policy changes were also identified. In this context, active participation of local communities is recognized as a key element, however, more effective policy implementation requires strong commitment and cooperation between government and communities. By building inclusive and transparent relationships, government policies can be more responsive to the unique needs of each community, creating a solid foundation for local community empowerment and sustainable progress nationally.
The Role of Artificial Intelligence in Improving the Quality of Student Learning Process
Authors: Yusuf Nasrullah
Published: June 2024

Artificial intelligence (AI) technology has become integral to student learning in the digital era. This article investigates the role of AI in improving the quality of the student learning process, focusing on personalization of learning, adaptive evaluation, and learning data analysis. This research uses a qualitative research approach. The research design adopted is a case study, which allows us to understand the implementation of artificial intelligence in student learning deeply. The research population and sample were 100 students at the Indonesian Technocrat University in Lampung province, Indonesia. The research results show that implementing AI in education has great potential to increase learning effectiveness, inclusiveness and efficiency. This confirms that adopting AI technology can significantly strengthen students' academic performance and prepare them to face future challenges.
Antecedents of Turnover Intention in Millennial Employees: Employee Engagement and Organizational Culture as Mediation Variables
Authors: Kaffaso Yoseph Vernon Suardi , Mahyuni Luh Putu
Published: June 2024

This research aims to find the antecedents of turnover intention in millennial employees, where employee engagement and organizational culture mediate. This research was conducted at banks in Bali Province. The population was all banking employees in Bali Province. From this population, 230 samples were taken, namely bank employees. Data was collected using a questionnaire method. The collected data was then analyzed using Structural Equation Modeling (SEM) Partial Least Squares (PLS). This research shows that professional identity and work environment negatively impact turnover intention, and professional identity positively impacts employee engagement and organizational culture. Next, the work environment positively impacts employee engagement and organizational culture. Employee engagement has a negative and significant effect on turnover intention; Organizational culture does not affect turnover intention, and Employee engagement can mediate the influence of professional identity on turnover intention. Employee engagement can mediate the influence of the work environment on turnover intention. Organizational culture cannot mediate the influence of professional identity on turnover intention. And organizational culture cannot mediate the influence of the work environment on turnover intention.”
The Role of Work Facilities, Employee Engagement, and Work Ethic in Enhancing Employee Performance with Job Satisfaction as an Intervening Factor at CV. Anugerah Tirta Persada Pangkalan Bun
Authors: Cipta Hendra , Hwihanus
Published: June 2024

This study explores the intricate relationships between work facilities, employee engagement, work ethic, job satisfaction, and employee performance within CV Anugrah Tirta Persada Pangkalan Bun. The research seeks to determine the impact of these factors on job satisfaction and how job satisfaction mediates their influence on employee performance. Utilizing a saturation sampling method, the study encompasses all 39 employees of the company. Data was collected via a comprehensive questionnaire covering respondent characteristics, work facility scale, work engagement scale, work ethic scale, job satisfaction scale, and employee performance scale, analyzed using SMARTPLS. Key findings reveal that work facilities and employee engagement do not significantly affect job satisfaction, as evidenced by p-values of 0.449 and 0.410, respectively. Conversely, work ethic significantly enhances job satisfaction with a p-value of 0.000. Job satisfaction is confirmed as a substantial predictor of employee performance (p-value 0.000). While job satisfaction significantly moderates the influence of employee engagement on performance (p-value 0.010), it does not moderate the effects of work facilities or work ethic on performance. Additionally, work ethic directly influences employee performance (p-value 0.012), while work facilities do not show a significant direct impact (p-value 0.177). These insights suggest prioritizing work ethic and employee engagement over work facilities to enhance job satisfaction and performance. The findings contribute valuable perspectives to human resource management practices, emphasizing the need for organizations to foster strong work ethics and employee engagement to boost overall performance.
БИШКЕК ШААРЫНДА 2012-ЖЫЛДАН 2023-ЖЫЛГА ЧЕЙИН БЕЙТАПТА АР КАНДАЙ ЭТИОЛОГИЯДАГЫ МЕНИНГИТТИ КАЙТАЛАП КАТТОО ПРАКТИКАСЫНАН БИР ОКУЯ
Authors: Рыскулбекова А.Б. , Уралиева М.К. , Чыналиева Р.Т.
Published: June 2024

В статье представлены результаты эпидемиологического расследования случая из практики повторной регистрации менингита различной этиологии у больного с 2012 по 2023 год в городе Бишкек. При проведении эпидемиологического расследования установлено, что ребенок переболел менингитом 8 раз. 2011 году в августе месяце получил черепно-мозговую травму с переломом лобной, височной, затылочной кости. Субарахноидальное кровоизлияние. В марте 2019 года больной прооперирован в Москве. С 2012 по 2023 годы больной переболел менингитом. В статье представлены график и таблица по годам регистрации менингита у больного.

Макалада 2012-жылдан 2023-жылга чейин Бишкек шаарында ар кандай этиологиядагы менингитти бир нече жолу каттаган бейтапка карата эпидемиологиялык иликтөөнүн жыйынтыгы берилген. Эпидемиологиялык иликтөөдө бала 8 жолу менингит менен ооруганы аныкталган. 2011-жылы август айында маңдай, самай жана желке сөөктөрү сынып, баш мээсине травма алган. Субарахноидалдык кан куюлуу. 2019-жылдын март айында бейтапка Москвада операция жасалган. 2012-жылдан 2023-жылга чейин бейтап менингит менен жабыркаган.

The article presents the results of an epidemiological investigation of a case from the practice of repeated registration of meningitis of various etiologies in a patient from 2012 to 2023 in the city of Bishkek. An epidemiological investigation revealed that the child had meningitis 8 times. In August 2011, he received a traumatic brain injury with a fracture of the frontal, temporal, and occipital bones. Subarachnoid hemorrhage. In March 2019, the patient underwent surgery in Moscow. From 2012 to 2023, the patient suffered from meningitis.
Experimental models of high-risk bowel anastomosis in rats: A systematic review
Authors: Ntampakis Georgios , Pramateftakis Manousos-Georgios , Anestiadou Elissavet , Bitsianis Stefanos , Ioannidis Orestis , Bekiari Chryssa , Koliakos George , Karakota Maria , Tsakona Anastasia , Cheva Angeliki , Angelopoulos Stamatios
Published: June 2024

BACKGROUND

Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity, that negatively affect the patients’ quality of life. Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation. Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features. Despite the advances in experimental protocols and techniques, designing a high-quality study is still challenging for the investigators as there is a plethora of different models used.

AIM

To review current state of the art for experimental protocols in high-risk anastomosis in rats.

METHODS

This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. To identify eligible studies, a comprehensive literature search was performed in the electronic databases PubMed (Medline) and Scopus, covering the period from conception until 18 October 2023.

RESULTS

From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis. Methods of assessing anastomotic healing were extracted and were individually appraised.

CONCLUSION

Anastomotic healing studies have evolved over the last decades, but the findings are yet to be translated into human studies. There is a need for high-quality, well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.
Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality
Authors: Inayat Faisal , Patel Pratik , Ali Hassam , Afzal Arslan , Tahir Hamza , Chaudhry Ahtshamullah , Ishtiaq Rizwan , Rehman Attiq Ur , Darji Kishan , Afzal Muhammad Sohaib , Nawaz Gul , Giammarino Alexa , Satapathy Sanjaya K
Published: June 2024

BACKGROUND

The coronavirus disease 2019 (COVID-19) pandemic has posed a major public health concern worldwide. Patients with comorbid conditions are at risk of adverse outcomes following COVID-19. Solid organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 infection. It could lead to higher rates of inpatient complications and mortality in this patient population. However, studies on COVID-19 outcomes in liver transplant (LT) recipients have yielded inconsistent findings.

AIM

To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United States.

METHODS

We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample database. Patients with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classification of Diseases, Tenth Revision coding system. The primary outcomes included trends in LT hospitalizations before and during the COVID-19 pandemic. Secondary outcomes included comparative trends in inpatient mortality and transplant rejection in LT recipients.

RESULTS

A total of 15720 hospitalized LT recipients were included. Approximately 0.8% of patients had a secondary diagnosis of COVID-19 infection. In both cohorts, the median admission age was 57 years. The linear trends for LT hospitalizations did not differ significantly before and during the pandemic (P = 0.84). The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December 2020. Compared to the pre-pandemic period, a higher association was noted between LT recipients and in-hospital mortality during the pandemic, with an odds ratio (OR) of 1.69 [95% confidence interval (CI): 1.55-1.84), P < 0.001]. The frequency of transplant rejections among hospitalized LT recipients increased from 0.2% to 3.6% between January 2019 and December 2020. LT hospitalizations during the COVID-19 pandemic had a higher association with transplant rejection than before the pandemic [OR: 1.53 (95%CI: 1.26-1.85), P < 0.001].

CONCLUSION

The hospitalization rates for LT recipients were comparable before and during the pandemic. Inpatient mortality and transplant rejection rates for hospitalized LT recipients were increased during the COVID-19 pandemic.
Pharmaceutical Synthesis and Discloser Approach Using Naïve Bayesian Method in Machine Learning a.
Authors:   Dept. of CSE, GCET, Hyderabad.
Published: June 2024

The headway and process steps are in innovation and appropriate strategies are set out a freedom for progress in numerous logical fields and different businesses. AI has become significant apparatus for drug plans and disclosure with the accessibility of spot information from enormous data sets. This article discuss about dissect ML and DL procedures it helps Pharmacy company’s in major related phases in medication disclosure they incorporates approval, future clinical events, and medical preliminaries. This application can be developed using machine learning techniques and using some important methods. This approach is very helpful in medicine industry. In present COVID situation vaccine development plays a major role to find the best medicine for that we have to test the medicine multiple times to test the results, if they did manual process they will take lot of time to update the details for that we are introducing this method. KEYWORDS: pharmaceutical synthesis, machine learning ML, Reinforcement learning RL, Medicine industry, supervised Machine Learning.
Juridical Analysis Of Cooperation Between Soes Through Company Formation Join Venture
Authors: Hardyan Saputra Yuvanda , Mahmudah Siti
Published: June 2024

The government continues to strive to optimize the value of SOEs through cooperation between SOEs or with partners. Therefore, the purpose of this study is to find out the legal provisions of cooperation in the establishment  of joint venture companies  from several SOEs, and to find out the principles and principles of implementing cooperation through the establishment of joint venture companies. This research uses a qualitative prescriptive approach with a Juridical-Normative type of research. The data sources used are secondary data obtained through primary legal materials, secondary legal materials and tertiary legal materials. Data retrieval techniques use literature studies and document studies. The data analysis was carried out in a qualitative descriptive manner. The results of this study found that between SOEs in accordance with the Minister of SOEs Number Per-07 / MBU / 04/2021 concerning Guidelines for Cooperation in State-Owned Enterprises can carry out cooperation through the formation of joint venture companies  such as PT Karya Logistik Nusantara (KLN) which is a joint venture company of six SOEs. The implementation of cooperation in the form of establishing joint venture companies  between SOEs is based on the principles of transparency, independence, accountability, responsibility, expediency, and fairness, and in accordance with the provisions of laws and regulations while the principle adopted is that cooperation is carried out indefinitely by prioritizing synergy between SOEs, between SOE subsidiaries, between BUMN affiliated companies and / or with Investment Management Institutions through direct appointment or direct cooperation by comparing at least two SOEs, subsidiaries, and affiliated companies of SOEs.
A Granular Framework for Modeling the Capacity Loss and Recovery of Regional Transportation Networks under Seismic Hazards: A Case Study on the Port of Los Angeles
Authors: Virtucio Michael , Cetiner Barbaros , Zhao Bingyu , Soga Kenichi , Taciroglu Erturgul
Published: June 2024

Earthquakes, being both unpredictable and potentially destructive, pose great risks to critical infrastructure systems like transportation. It becomes crucial, therefore, to have both a fine-grained and holistic understanding of how the current state of a transportation system would fare during hypothetical hazard scenarios. This paper introduces a synthesis approach to assessing the impacts of earthquakes by coupling an image-based structure-and-site-specific bridge fragility generation methodology with regional-scale traffic simulations and economic loss prediction models. The proposed approach’s use of context-rich data such as OpenStreetMap and Google Street View enables incorporating information that is abstracted in standard loss analysis tools like HAZUS in order to construct nonlinear bridge models and corresponding fragility functions. The framework uses a semi-dynamic traffic assignment model run on a regional traffic network that includes all freeways and local roads (1,444,790 edges) and outputs traffic volume on roads before and after bridge closures due to an earthquake as well as impacts to individual trips (42,056,426 trips). The combination of these models enables granularity, facilitating a bottom-up approach to estimating costs incurred solely due to physical damage to the transportation network. As a case study, the proposed framework is applied to the road network surrounding the Port of Los Angeles---an infrastructure of crucial importance---for assessing resilience and losses at a high resolution. It is found that the port area is disproportionately impacted in the hypothetical earthquake scenario, and delays in bridge repair can lead to a 50% increase in costs.
Pengaruh Model Self-Directed Learning (SDL) Terhadap Kemampuan Menulis Teks Eksplanasi Kompleks Pada Siswa Kelas XI SMA Swasta Abdi Negara Binjai
Authors: Simanungkalit Atri Novela , S Monalisa Frince , Sitohang Tigor
Published: June 2024

The purpose of this study is to determine the influence of the use of the Self-Directed Learning (SDL) learning model on the ability to write complex explanation texts in Grade XI students of Abdi Negara Private High School Binjai Academic Year 2023/2024. This research is quantitative with an experimental research method, using a One Group Pretest and Posttest research design. The research population is 82 and the sample is 30 people. Sampling was done using Cluster Sampling technique. The results of the pretest show that the number of students who passed the Minimum Completion Criteria (KKM) in writing complex explanation texts is 6 people (20%). and after using the learning model, there is an increase in the number of students who achieve the learning completeness standard by 23 (76%) people. Obtained 1-calculation 5.58 and Label 1.70 then Ho rejected and H1 accepted. It is concluded that the use of the Self-Directed Learning (SDL) learning model can improve students' news writing abilities in Indonesian language lessons at the Grade XI level of high school.
Pengaruh Pembelajaran Berdiferensiasi Berbantuan Media Cartoon Story Maker Terhadap Kemampuan Menulis Teks Negosiasi Kelas X Di SMA Perguruan Teladan Medan
Authors: Samosir Sarah Evelyn , Sitorus Pontas Jamaluddin , Saragih Elza L.L
Published: June 2024

This research aims to determine the effect of differentiated learning assisted by Cartoon Story Maker media on the ability to write negotiation texts for class X at Teladan Medan High School. This research is quantitative research that uses experimental methods with a two group posttest research design. The population studied was all class X students totaling 75 people and the samples in the research were class X1 with a total of 25 people and The data analysis techniques used include normality testing with the F test, homogeneity testing, and hypothesis testing. After carrying out the research, namely the posttest using Differentiated Learning assisted by the Cartoon Story Maker Application, the average score for the control class posttest was 54.6 and the experimental class posttest was 76. The results of hypothesis testing in this study obtained tcount>ttable (7.40 > 1, 98) thus, Ho is rejected and Ha is accepted and the test results of the posttest requirements are normally distributed and homogeneous. So it can be concluded that the Influence of Differentiated Learning Assisted by Cartoon Story Maker Media on the Ability to Write Negotiation Texts for Class X SMA Teladan Medan.
Dificultades legales en la ruta hacia la justicia
Authors: Jerez Rivero Wilbemis , Gutiérrez Abreu Bárbara
Published: June 2024

El acceso a la justicia de las personas con discapacidad enfrenta múltiples desafíos en áreas legales, arquitectónicas, culturales, económicas, procedimentales y comunicativas. Estos desafíos limitan su capacidad para buscar una tutela efectiva de sus derechos e intereses legítimos, lo que crea una vulnerabilidad particular en este grupo vulnerable. Frente a estos derroteros, este artículo se enfoca en analizar en profundidad las barreras comunicativas que dificultan el acceso a la justicia de las personas con discapacidad. Se abordarán estas limitaciones específicas y se explorarán soluciones potenciales, haciendo especial hincapié en la implementación de ajustes razonables. Así, se destacará la importancia de utilizar un lenguaje claro e inclusivo, la disponibilidad de documentos en braille, la presencia de intérpretes de lengua de signos y la figura del facilitador judicial. Además, se pretende que estos ajustes, inspirados en instrumentos de aplicabilidad directa, encuentren su aplicación en los tribunales cubanos, y que, tal como se proclama en el artículo 40 en relación con el artículo 89 de la Constitución cubana, se garantice la igualdad en el acceso a la justicia de las personas con discapacidad.
Leveraging Linkedin to Successfully Launch and Grow a Freelancing Career
Authors: Petrus Cecilia , Balaji Bhavadharini
Published: June 2024

When used to its full potential, LinkedIn can be a powerful networking and marketing tool for medical writers and other professionals. Bhavadharini Balaji, PhD, started her medical writing journey in late 2022 after completing 2 postdoctoral fellowships and working as a senior consultant at a global contract research organization. Today, she has a successful career as a freelance medical writer and mentor, with LinkedIn playing a substantial role in facilitating the transition.
In this article, Balaji shares her journey from academia to self-employment and discusses how LinkedIn has helped her gain knowledge, market herself and her services, and grow her business. Among many other advantages, Balaji highlights that LinkedIn can serve as a bridge, connecting medical writers with other professionals who can provide valuable insights and referrals, ultimately contributing to business growth. By crafting and curating content on LinkedIn that reflects one’s expertise, passions, and unique selling points, freelancers can develop a personal brand that resonates with their target audience. As such, the social media platform has allowed her to create a compelling narrative, showcase her journey authentically, and make herself relatable through the sharing of insights and stories about her expertise, challenges, and successes. Nevertheless, having a strong social media presence is not enough to launch a career, with coaching, mentoring, and past in-house medical writing experience also playing important roles in Balaji’s success.
Optimizing Continuing Education for Health Professionals: Incorporating Instructional Design Principles and Frameworks for Effective Learning
Authors: Prahst Claudia
Published: June 2024

Medical writers who work in continuing medical education (CME) and continuing education (CE) are tasked with crafting resources for clinicians to stay up to date with the most recent advances in medicine. These CME/CE activities are designed to improve knowledge, competence, performance, and/or patient outcomes. For CME/CE to achieve these desired outcomes, medical writers can follow principles of instructional design during CME/CE development. At different stages of CME/CE development, medical writers can incorporate various conceptual frameworks and models. Commonly used frameworks to develop CME/CE activities include the plando-study-act cycle, Bloom’s taxonomy, and Moore’s levels. Medical writers can use these frameworks and models to help create learning experiences that are engaging and learner-centered, resulting in changed clinical behavior and improved patient outcomes.
The Influence of Animation Videos on Expressive Language Skills in Preschool Kobar Anugerah, Batujala Village, Bontoramba District, Jeneponto Regency
Authors: M Syamsidar. , Herlina Herlina , Musi Muhammad Akil
Published: June 2024

This research aims to: 1) find out what the effect is after being given an animated video at the Kobar Anugrah Early Childhood Education in Batujala Village. 2) To find out what the influence was before being given an animated video at the Kobar Anugrah Early Childhood Education in Batujal Village. 3) To find out whether there is an influence of learning videos in Kobar Anugrah Early Childhood Education in Batujala Village. This research is a quantitative descriptive research by describing variables that support the data in the form of numbers generated from the actual situation. This research uses primary data which collects data using questionnaires and interviews. The researcher uses quantitative analysis, multiple linear regression analysis and analysis of the coefficient of determination. with the help of SPSS17. The population in this study was 47 early childhood children at the Kobar Anugrah Early Childhood Education School, Batujala Village, carried out on May 15 2023 at Kobar early childhood education in Batujala Village, Bontoramba District, Jeneponto Regency, South Sulawesi Province. The results of the research obtained using the Animated videos have the effect of helping young children be active in expressive language at early childhood education schools in Kobar, and teachers are also more active in the early childhood education learning process using animated digital media learning methods. And master digital media materials with animated video materials.
Tendências e eficácia do uso do Canabidiol no tratamento do autismo: uma revisão sistemática
Authors: Martins Meriane Ponçadilha , Toledo Carlos Augusto Barboza
Published: June 2024

Se reconhece que são vários os estudos destinados a comprovar a eficácia terapêutica da Cannabis sativa e seus derivados voltados para o tratamento do autismo. Nota-se que inexiste tratamento específico para o transtorno do espectro autista, e as intervenções dão ênfase para a redução de comportamentos   perturbadores, devendo ser a terapia de caráter multidisciplinar, com opção da inclusão de medicamentos à base de canabidiol como terapia complementar.  O problema foi: Quais os benefícios e vantagens do uso do canabidiol como alternativa no tratamento do transtorno do espectro autista? O objetivo foi avaliar o uso e benefícios do canabidiol para fins medicinais no tratamento do espectro autista. Tratou-se de uma revisão bibliográfica, com seleção de material publicado entre 2017 a 2023 nas bases de dados da SCIELO, LILACS, BVS. Foi encontrado 156 artigos, 11 completaram os critérios de inclusão. Nota-se que várias pesquisas sugerem o alto potencial terapêutico do canabidiol no TEA, com resultados positivos para melhorias dos sintomas e comportamentos, contudo ainda se verifica a necessidade de investir em pesquisas e estudos clínicos controlados para compreender os benefícios, dosagens ideais e riscos associados. Concluiu que o uso de medicamentos derivados do canabidiol na terapia complementar de autistas, produz bons resultados no controle da sintomatologia da doença, com melhoria na funcionalidade diária, maior controle dos distúrbios comportamentais, melhor qualidade do sono  e na qualidade de vida do paciente, devendo o farmacêutico integrar a equipe multidisciplinar, a fim de realizar o acompanhamento farmacoterapêutico deste medicamento, considerando as necessidades particulares de cada paciente.
Tendência da Hanseníase no município de Porto Nacional-TO, no período de 2012 a 2022
Authors: Magalhães Giselle Paz , Costa Mariana Ferreira , Reis Samara Pereira , Franchi Eliane Patrícia Lino Pereira
Published: June 2024

A Hanseníase, provocada pela bactéria Mycobacterium leprae, é uma doença infectocontagiosa de evolução crônica. Desta maneira, o presente estudo possui como objetivo analisar a tendência temporal da hanseníase no município de Porto Nacional-TO, no período de 2012 a 2022. Foi desenvolvido um estudo ecológico, transversal, retrospectivo, descritivo de análise quantitativa. A pesquisa foi realizada com casos de hanseníase notificados na cidade de Porto Nacional-TO, utilizando informações fornecidas pelo Sistema de Informação de Agravos e Notificações (SINAN/DATASUS), vinculado ao Ministério da Saúde. No período de 2012 a 2022 foram notificados no município de Porto Nacional-TO, um total de 874 casos de hanseníase. Quanto ao sexo, o mais prevalente foi o masculino (n=505). 74% dos pacientes notificados no município de Porto Nacional-TO, eram de cor parda, com maior representatividade na faixa etária de 30 a 59 anos (56%), com ensino fundamental incompleto (31%). 81% foram multibacilar, sendo a maioria dimorfa (70%), com grau de incapacidade zero (38%) seguido do grau de incapacidade I (36%), com 2 a 5 lesões (36%), sem episódio reacional (86%), com esquema terapêutico de poliquimioterapia multibacilar de 12 doses (81%). Ao final, percebeu-se que a tendência temporal da hanseníase no município de Porto Nacional-TO, no período de 2012 a 2022 demonstrou-se estacionária, apesar de ter sido observado comportamento decrescente no ano de 2020. Pode-se afirmar que a hanseníase, no município, é um problema de saúde pública, pois apresentou-se com quantitativos de casos estacionários, porém constantes, embora seja um problema de saúde curável e que possui baixa recidiva.
A indicação geográfica (IG) para a farinha de Buerarema como estratégia de proteção aos produtores locais
Authors: Midlej Emanuel Marques , Sales Jorge Henrique de Oliveira
Published: June 2024

A região circunvizinha à cidade de Buerarema, também conhecida como “Bolsão do Maruin” (área rural contida nos municípios de Buerarema, São José da Vitória, Ilhéus e Una, no sul da Bahia) possui a produção da mandiocultura notoriamente reconhecida como produtora de farinha de excelente qualidade. Visando agregar confiabilidade e reconhecimento nacional, é apresentado neste trabalho pontos de atenção a serem observados numa estratégia de mercado baseada no registro da Indicação Geográfica (IG) da farinha de mandioca de Buerarema. A exemplo de algumas IGs tem-se: a Champagne da região francesa, o vinho do Porto de Portugal, o café da Colômbia, o queijo Parmigiano-Reggiano da Itália, queijo da Canastra e Cachaça de Salinas no Brasil. O registro de IG é conferido a produtos ou serviços que são característicos do seu sítio de origem, o que gera renome e valor, além de os diferenciar em relação aos seus concorrentes disponíveis à venda. São milhares de IGs registradas no mundo e a maioria pertence ao setor agrícola e de alimentos e o valor comercial delas é estimado em bilhões de dólares. O trabalho é de natureza aplicada e através de uma pesquisa qualitativa, exploratória, e com uso do procedimento técnico de pesquisa-ação e bibliográfica. Como resultado apresenta-se os principais aspectos que o possível registro da IG para a Farinha de Buerarema deve observar e definir a fim de proteger seu produto da competição local e também em mercados globais.
A reclamação constitucional e as decisões da justiça do trabalho
Authors: Silva Eli Alves da , Thamay Renan
Published: June 2024

O presente artigo busca estabelecer as bases constitucionais da Reclamação Constitucional como um meio de garantir a autoridade de uma decisão proferida por determinado tribunal ou a exequibilidade de súmula vinculante emanada pelo STF, demonstrando sua natureza jurídica, nos moldes do CPC/15, em seu Art. 988, demonstrando similitudes com o mandado de segurança, estabelecendo que o objeto é estritamente de direito, instruída com documentação pré-constitutiva, incidindo, ainda, honorários sucumbenciais, nos termos do Art. 85, §2º do CPC. A pesquisa foi realizada através do método indutivo, através de bibliografias como doutrina, legislação e jurisprudência. A finalidade do artigo é demonstrar, na justiça do trabalho, a necessidade de autoridade das decisões dos tribunais, sobretudo, pela prevalência das decisões proferidas pelo STF em súmula vinculante.
Tarım Sigortası Yaptıran ve Yaptırmayan Elma İşletmelerinin Maliyet ve Kârlılık Analizi: Denizli İli Çivril İlçesi Örneği
Authors: Tekin Ayşe , Karlı Bahri
Published: June 2024

Elma, dünyada ekonomik anlamda üretimi ve ticareti yapılan en önemli meyveler arasında yer almaktadır. Türkiye elma üretiminde, dünyada elma üretimi yapan 95 ülke arasında 2022 verilerine göre Çin’in ardından 2. sırada yer almaktadır. Türkiye’de elma üretiminde Isparta, Karaman, Niğde, Antalya, Denizli, Konya, Kayseri ve Mersin illeri öne çıkmaktadır. Araştırma verileri, üreticiler ile yüz yüze görüşülerek anket yöntemi ile elde edilmiştir. Elma üretimi yapan üreticilerin işletme başına ortalama üretim masrafları 70 254.18 TL olarak hesaplanmıştır. Bunun %57.18’i değişen masraf, %42.82’sini ise sabit masraflar olduğu tespit edilmiştir. Sigorta yaptıran üreticilerin üretim masrafları 97 597.14 TL, sigorta yaptırmayan üreticilerin ise 42 911.22 TL olarak tespit edilmiştir. İşletmelerin gayri safi üretim değeri ise sigorta yaptıran üreticilerde 120 318.06 TL, sigorta yaptırmayan üreticilerde ise 51 206.25 TL olarak belirlenmiştir. Üreticilerin kârlılık göstergelerinde ise nispi kâr bakımından sigorta yaptıran işletmelerin (1.23), sigorta yaptırmayan işletmelerden (1.19) daha yüksek kâr elde ettiği ortaya konulmuştur. Elma üretiminde kilogram başına kâr marjı bakımından sigorta yaptıran işletmelerin (0.20 TL/kg), sigorta yaptırmayan işletmelere (0.15 TL/kg) göre daha avantajlı olduğu tespit edilmiştir. Tarım sigortası uygulamasının yaygınlaşması ve üreticilerin tarım sigortası yaptırma oranı arttıkça, üreticilerin; karşılaşılan doğal afet zararlarından daha az zarar görmesi ve maddi kayıplarının azalması söz konusu olabilecektir.
Destek Bitki Olarak Farklı Oranlarda Tritikale Kullanımının Macar Fiğinde Tohum Üretimi Üzerine Etkilerinin Belirlenmesi
Authors: Alıcı Aytaç Zafer , Türk Mevlüt
Published: June 2024

Bu çalışma, Macar fiği tohum üretiminde, destek bitki olarak farklı oranlarda tritikale karıştırılmasının tohum üretimi üzerine etkisini belirlemek amacıyla Eskişehir Geçit Kuşağı Tarımsal Araştırma Enstitüsü’nde 2021-2022 yetiştirme sezonunda yürütülmüştür. Denemede Macar fiğinin Akçalar çeşidi ve tritikalenin Karma-2000 çeşidi kullanılmıştır. Deneme tesadüf blokları deneme desenine göre 3 tekerrürlü olarak yürütülmüştür. Çalışmada Macar fiğine 7 farklı oranda (%0, 5, 10, 15, 20, 25, 30) tritikale karıştırılmıştır. Araştırmada bitki boyu, bitkide bakla sayısı, baklada tane sayısı, bin tane ağırlığı, biyolojik verim, tohum verimi ve kes verimi incelenmiştir. Farklı oranda tritikale karıştırılması incelenen tüm özellikler üzerine istatistiki olarak önemli etki yapmıştır. Araştırma sonuçlarına göre, tritikale oranlarına bağlı olarak, bitki boyu 44.10-57.50 cm, bitkide bakla sayısı 9.9-16.27 adet/bitki, baklada tane sayısı 4.33-5.67 adet/bakla, bin tane ağırlığı 44.83-47.93 g, biyolojik verim 165.17-555.27 kg/da, tohum verimi 18.92-73.05 kg/da, kes verimi 146.08-481.95 kg/da arasında değişim göstermiştir. Sonuç olarak, Eskişehir ekolojik koşullarında Macar fiğ tohumluk üretiminde destek bitki olarak %10 tritikale karıştırılmasının en uygun sonuç olduğu tespit edilmiştir.
Impact of diet supplementation of enzymes during hot weather conditions on milk production and nutrient utilization in Murrah buffaloes
Authors: KUMAR ANUJ , KUMAR AMIT , SINGH D K , ROY DEBASHIS , SINGH MANOJ KUMAR , SARKAR T K , KUMAR ROHIT , YADAV VIVEK KUMAR
Published: June 2024

An experiment was conducted to evaluate the impact of diet supplementation of enzymes during hot weather conditions on milk production and nutrient utilization in Murrah buffaloes. Twenty four Murrah buffaloes were distributed randomly into four equal groups (T1, T2, T3 and T4) with six buffaloes in each, on the basis of their body weight, lactation length and test day milk yield. Feeding trial was planned into four treatment groups, viz. T1 (Basal diet without enzyme supplementation), T2 (Basal diet with supplementation of Xylanase @800000 IU), T3 (Basal diet with supplementation of Cellulase @240000 IU) and T4 (Basal diet with supplementation of Xylanase @800000 IU and Cellulase@240000 IU). The results revealed that the average milk yield (5.93 L/day) was higher in T4 as compared to other treatment groups, i.e. 5.47, 5.59 and 5.88 L/day in T1, T2 and T3 group, respectively. Statistically the difference in milk yield was significantly higher in cellulase supplemented groups. The milk fat (%) was significantly higher in enzyme supplemented over control group. The results were shown an increment in all other major milk constituents in enzyme supplemented group in comparison to control group, while statistically the difference was found non-significant. The average DM intake (kg/d, kg/100 kg body wt. and g/kg W0.75) remained static in all treatment groups while the CP intake (g/d, g/100 kg BW and g/kg W0.75) was significantly higher in cellulase supplemented buffaloes. The TDN intake (kg/d, kg/100kg BW and g/kg W0.75) was significantly higher in enzyme supplemented groups. Similarly the digestibility coefficient of CF, NDF and ADF were higher in buffaloes of T3 and T4 over control (T1) group. So, it is concluded from the present study that the milk production and milk composition improves in the combine use of xylanase and cellulase enzyme supplemented groups of buffaloes due to enhanced protein and energy intake and fibre digestibility.
Haematological changes to assess stress arising from different methods of slaughtering in pigs
Authors: SUARDANA I WAYAN , ARISTHA DEWI I GUSTI AYU PUTU , UTAMA IWAN HARJONO
Published: June 2024

This study aimed to investigate the blood profile and neutrophil and lymphocyte ratio (NLR) in pigs subjected to stunning and non-stunning. Forty pigs, aged between 6-8 months and weighing 80-100 kg, were used to assess haematological changes associated with different slaughter techniques and to evaluate stress levels. The samples were divided into two groups, the first group was subjected to stunning (with a captive bolt), and the other served as a non-stunning (control). Blood samples were collected from each pig using EDTA anticoagulant tubes, with 3 mL of blood collected per sample. These samples were then analyzed using an auto-haematology analyzer to measure various parameters including RBC, HB, PCV, MCV, MCH, WBC, neutrophils, lymphocytes, monocytes, and eosinophil, as well as the ratio of neutrophils and lymphocytes. The results showed that stunning pigs with a captive bolt exhibited significantly higher levels of RBC, PCV, and lymphocytes with a value of 8.144±1.66 (×106/µL); 41.5±13.62(%) and 41.805±7.82(%), compared to non-stunning pigs with a value of 7.209 ± 1.22 (×106/µL); 36.65±6.12(%); and 22.2±12.24 (%), respectively. However, stunning pigs exhibited lower WBC and neutrophils, measuring 13.825 ± 8.56 × 103/µL and 41.75±16.64(%) with captive bold, compared to non-stunning pigs with a value of 20.375±9.83 (×103/µL) and 63.30±19.04 (%) respectively. The NLR index was higher in non-stunning pigs, with a value of 2.851, compared to stunning pigs subjected to a captive bolt, with an index of 1.006. In conclusion, stunning with a captive bolt was found to reduce the stress level of pigs before slaughter, potentially leading to improvements in meat quality.
Study of association of type traits with lifetime milk traits in Frieswal cattle
Authors: CHOPADE M M , JAHAGEERDAR SHRINIVAS , KATKADE B S , DESHMUKH R S , SAWANE M P
Published: June 2024

Most of the type traits have positive correlated response with lifetime traits. Therefore, these traits are important for selection of animals for high milk yield. Moreover, the udder depth can be used as a good indicator for predicting lifetime milk yield and length of productive life. Lastly, the selection may be supported with the detected QTLs, significant SNPs and candidate genes which are the potential tools to improve the lifetime traits.
Los diseños curriculares universitarios como políticas públicas para el desarrollo humano de las comunidades locales
Authors: Stigliano Daniel Ernesto
Published: June 2024

Los diseños curriculares universitarios desempeñan un papel fundamental en la formación de individuos capaces de contribuir al desarrollo humano de las comunidades locales. Estos diseños no solo definen qué se enseña en las instituciones educativas, sino que también, tienen el potencial de influir en la dirección y el enfoque de las políticas públicas destinadas a promover el desarrollo humano sostenible. En este artículo, se explora cómo los diseños curriculares universitarios pueden ser concebidos y ejecutados como políticas públicas efectivas para el desarrollo humano de las comunidades locales, examinando ejemplos, investigaciones y teorías relevantes en el campo. A modo de conclusión, se propone un instrumento de análisis basado en el enfoque de capacidades que una vez aplicado por las instituciones de educación superior ofrecerá información útil para orientar los perfiles profesionales de los graduados de acuerdo con las características del enfoque de capacidades.