bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Long-Term Ketogenic Diet in Mice Serum Adiponectin
Authors: Kurniasari Hamidah , Rejeki Purwo Sri , Kahar Hartono , Sunarti Sri
Published: March 2022

Highlight:Adiponectin is an important protective factor for cardiovascular disease and increased insulin sensitivity.Ketogenic diet effect on adiponectin level in mice besides decrease weight gain was determined.The difference in serum adiponectin level and body weight is uncorrelated. Abstract:Ketogenic diet is a popular diet to reduce weight gain quickly. This diet has become a lifestyle . The ketogenic diet has been reported to affect adiponectin level, although it is still contraindicated. Adiponectin is a biomarker for metabolic disease that plays an important role as a protective factor for cardiovascular disease and increase insulin sensitivity. This study aimed to explore the effect of the ketogenic diet on adiponectin level in mice, besides decrease weight gain. This study was an experimental laboratory study with a randomized post-test-only control group design. Fourteen male mice (20-30 g) aged 2-3 months were divided randomly into K1 (n=7, standard diet) and K2 (n=7, ketogenic diet), were given diet for eight weeks, ad libitum. Body weight was measured at the pre and post-intervention, whereas adiponectin level were measured at the post-intervention using ELISA. The statistical analysis using SPSS version 16. The Shapiro Wilk test was used to determine normality, Independent T-Test was used to determine mean difference for normal distribution, Mann Whitney Test was used to determine mean difference for abnormal distribution, and Pearson Correlation was used to determine correlation. Difference (∆) of body weight on K1 (12.00±6.26) g, K2 (1.29±7.41) g with p=0.02. Serum adiponectin level of K1 (0.082±0.014) µg/ml and K2 (0.096±0.008) µg/ml with p=0.035. This study showed ketogenic diet-induced higher serum adiponectin level and slower weight gain. There is no correlation between the difference in body weight and serum adiponectin level (p=0.403).
Skill Improvement for Public Health Center Staffs in the Management of Toxic and Hazardous Materials
Authors: Djuari Lilik , Dewanti Linda , Sulistiawati Sulistiawati , Mahendra Arya Ivan , Fahruddin Ahmad Cholifa
Published: March 2022

Highlight:There was an increase in the accumulation of B3 waste in health centers during the COVID-19 pandemic.The knowledge and skills level of health center staff in medical THM waste management before and after medical THM waste management training were determined.Medical THM waste management training was increasing the knowledge and skills level of health center staff. Abstract:The generation of medical toxic and hazardous material (THM) waste at public health centers tends to increase during the Covid-19 pandemic. Only 6.89% of the health centers have medical waste management practices that meet the standards. Medical waste management practices not in accordance with the procedures can be a source of infection, even though only 56% of health workers have good knowledge and attitudes in solid medical waste management. For this reason, it is necessary to increase the skills of health center staff in managing medical THM waste during the Covid-19 pandemic. The purpose of this study was to determine the level of knowledge and skills of health center staff in medical THM waste management before and after medical THM waste management training. The training participants were 20 health center staffs who filled out a pretest questionnaire to measure their level of knowledge and skills prior to the training. The training materials include THM waste, medical THM waste, medical THM waste management and medical THM Temporary Storage. After the training, a post-test was conducted to measure the knowledge and skills scores of the trainees. The results of this study indicated that there was a significant difference in knowledge before and after training (p < 0.05). The average knowledge score before training was 6.2 (sufficient knowledge) and after training 8.15 (good knowledge). There was a significant difference in skill scores before and after training (p <0.05). The average skill before training was 6.3 (adequate) and after training 8.65 (good). In conclusion, there was an increase in the skills of health center staff in managing medical THM waste during covid-19 pandemic after participating in medical THM waste management training by the Community Service Team, Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Acute Diarrhea Patients among Children Under Five Hospitalized in a Tertiary Hospital in East Java, Indonesia
Authors: Adiba Asmahan Farah , Soedarmo Subijanto Marto , Sulistiawati Sulistiawati , Athiyyah Alpha Fardah
Published: March 2022

Highlight:The characteristics of acute diarrhea patients among chidren in Tertiary Hospital In East Java was evaluated.The highest incidence of diarrhea was found in the 0-24 months age group, good nutritional status, male sex, and hospitalized in less than 5 days.Mild-moderate dehydration, intravenous rehydration treated, anemia, hyponatremia, and metabolic acidosis were mostly founded. Abstract:Diarrhea is the second leading cause of morbidity and mortality in children under five years of age in Indonesia after pneumonia. In 2017, diarrhea became an outbreak in 12 provinces. Diarrhea in under-fives can cause several complications and can cause death if it is not treated properly. This study aimed to evaluate the characteristics of acute diarrhea patients in under-fives hospitalized in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia for six months. This study was a descriptive study with retrospective approach which evaluated all acute diarrhea patients hospitalized from July to December 2019. Patients’ data were taken from medical records and presented descriptively. Of the total 125 patients, most acute diarrhea patients were male (60%) aged 0 to 24 months (83.2%), had good nutritional status (58.4%), and hospitalized for less than 5 days (60.8%). The most degree of dehydration was mild-moderate dehydration (83.2%), mostly treated with intravenous rehydration (96.8%), the most common comorbidity was anemia (13.4%), and the most electrolyte disorder was hyponatremia (41%), while acid-base disorder was mostly metabolic acidosis (75%).
Molecular chemisorption: a new conceptual paradigm for hydrogen storage
Authors: Lang Chengguang , Jia Yi , Yan Xuecheng , Ouyang Liuzhang , Zhu Min , Yao Xiangdong
Published: March 2022

Developing efficient hydrogen storage materials and the corresponding methods is the key to successfully realizing the “hydrogen economy”. The ideal hydrogen storage materials should be capable of reversibly ab-/desorbing hydrogen under mild temperatures with high hydrogen capacities. To achieve this target, the ideal enthalpy of adsorption is determined to be 15-50 kJ/mol for hydrogen storage. However, the current mainstream methods, including molecular physisorption and atomic chemisorption, possess either too high or too low enthalpy of hydrogen adsorption, which are not suitable for practical application. To this end, hydrogen storage via molecular chemisorption is perceived to regulate the adsorption enthalpy with intermediate binding energy between the molecular physisorption and atomic chemisorption, enabling the revisable hydrogen ad-/desorption possible under ambient temperatures. In this perspective, we will elaborate the molecular chemisorption as a new conceptual paradigm and materials design to advance future solid-state hydrogen storage.
Peningkatan Fungsi RTH menjadi Ruang Bermain Ramah Anak di Kelurahan Cempaka Kota Banjarbaru
Authors: Aufa Naimatul , Mentayani Ira , Wastuty Prima Widia , Andini Dila Nadya , Fawzia Irma
Published: March 2022

Ruang Bermain Layak Anak (RBRA) merupakan tanggung jawab pemerintah dalam memenuhi hak anak-anak sebagai warga negara untuk memiliki waktu beristirahat, melakukan aktivitas seni, budaya, dan olahraga. RBRA menjadi fasilitas bermain dan rekreasi yang mampu menjadi wadah untuk masyarakat, terutama anak-anak untuk mengembangkan kreativitasnya. Berdasar hasil kajian penelitian kerjasama antara tim peneliti dari Pusat Studi Pembangunan Permukiman Perkotaan LPPM ULM dan Badan Perencanaan Pembangunan Penelitian dan Pengembangan Daerah Kota Banjarbaru tentang Kajian Ruang Bermain Ramah Anak Kota Banjarbaru, tim peneliti berinisiatif untuk membuat desain RBRA pada ruang terbuka warga di Kelurahan Cempaka. Pengabdian kepada masyarakat ini bertujuan memberikan gagasan rancangan RBRA untuk meningkatkan fungsi eksisting ruang terbuka yang berlokasi di Kelurahan Cempaka Kota Banjarbaru. Metode pelaksanaannya melalui evaluasi purna huni. Hasil pengabdian kepada masyarakat ini berupa rancangan RBRA yang meliputi rancangan tapak, perabot bermain dan perabot lingkungan.
Peningkatan Kualitas Visual Pasar Bauntung Banjarbaru melalui Desain Penanda dan Penunjuk Arah
Authors: Heldiansyah J. C. , Aufa Naimatul , Hadinata Irwan Yudha , Muchamad Bani Noor , Saud Muhammad Ibnu , Rahman Muhammad Sahdianor , Rizaldi Riza Azmi , Sari Florensita Puspita , Rahmanto Adi
Published: March 2022

Pasar Bauntung Banjarbaru merupakan salah satu pasar yang dikelola oleh Dinas Perdagangan Kota Banjarbaru dibawah pengelolaan UPTD Pasar Bauntung. Pasar bauntung baru beroperasi kurang dari satu tahun. Pasar Bauntung pada saat ini menghadapi permasalahan tidak tersedianya penanda dan petunjuk arah yang representatif, hal ini dikarenakan pengelola pasar belum memiliki arahan desain penanda dan petunjuk arah untuk opreasional pasar. Masing-masing pedagang berinisiatif membuat penanda tokonya, sehingga terjadi kekacauan visual. UPTD Pasar Bauntung melalui surat Nomor: 511.2/047/UPTD.PSR.BB berinisiatif untuk mengajak Tim Arsitektur FT ULM untuk bekerjasama melaksanakan kegiatan Peningkatan Kualitas Visual Pasar Bauntung Banjarbaru melalui Desain Penanda & Penunjuk Arah. Fakultas Teknik menyambut baik hal ini dengan menunjuk Tim Arsitek dari Program Studi Arsitektur. Kegiatan dimulai dengan riset sederhana untuk digunakan sebagai dasar merumuskan konsep dan desain penanda & penunjuk arah pasar Bauntung Banajrbaru. Hasil pengabdian ini menghasilkan rancangan yang dipaparkan dan diserahkan ke Kepala Dinas Perdagangan, Kepala UPTD Pasar Bauntung, dan staf pengelola pasar Bauntung Kota Banjarbaru.
Pengembangan Keterampilan Pertunjukan Madihin Di Komunitas Madihinesia Kalimantan Selatan
Authors: Sani Muhammad Budi Zakia
Published: March 2022

Madihin art is an art that has a very strong local wisdom value. This art is played by individuals, in pairs, or in groups by madihin players called pamadihinan. Madihin art continues to grow in the wider community, its fans are emerging from the younger generation from various backgrounds and elements. They were gathered in a community which they named Madihinesia. This Madhinesian community was attended by dozens of members who were active and engaged in art activities in South Kalimantan. This community built a movement that aims to preserve and develop madihin art in South Kalimantan. Therefore, in this service activity, training is carried out aimed at developing the potential and skills possessed by the pamadihinan in the Madisonian community, so that it is a very big hope that they will be able to have increased skills in the future
Peningkatan Kualitas Pembelajaran pada MDTA (Madrasah Diniyah Takmiliyah Awaliyah) Baiturrahman di Kelurahan Merdeka
Authors: Wandansari Sarah Adilah , Fanyarti Diah , Salam M Fadlani , Mukhlishah Mukhlishah , Supala Supala , Riyadi Hendar
Published: March 2022

Sasaran pengabdian ini adalah MDTA (Madrasah Diniyah Takmiliyah Awaliyah) Baiturrahman yang berlokasi di Kelurahan Merdeka, Kecamatan Sumur Bandung, Kota Bandung. Sebagai salah satu dari penyelenggara proses pembelajaran ilmu-ilmu agama, MDTA juga mengambil peran penting dalam pembentukan nilai-nilai agama. Sayangnya, alokasi waktu yang masih minim menjadikan prosesnya tidak begitu efektif. Untuk tetap dapat memperoleh kualitas yang baik dan efektif maka perlu adanya keselarasan dengan unsur proses. Lokasi MDTA Baiturrahman dipilih sebagai tempat pengabdian, karena beberapa unsur proses belum terpenuhi. Unsur yang difokuskan meliputi dua hal yaitu pembenahan administrasi dan kurikulum. Sehingga kegiatan utama berkutat untuk melengkapi unsur yang masih belum sempurna. Hal ini diwujudkan dalam bentuk pembuatan program software yaitu microsoft excel serta pengarahan dalam pembuatan sistem administrasi MDTA Baiturrahman untuk pencatatan. Sementara untuk memenuhi kurikulum yang sesuai standar, input kurikulum Kemenag terbaru juga dimaksimalkan. Selain itu tidak ketinggalan berbagai aktivitas yang mendukung terwujudnya tujuan diatas adalah dengan pengelolaan kelas dan kantor, pengadaan akses internet, pembenahan nuansa kelas, pelatihan guru, pojok literasi, dan penyediaan fasilitas tabungan umroh bagi para guru MDTA sebagai bentuk apresiasi. Seluruh rencana yang ditetapkan telah berjalan dengan baik, sekalipun beberapa diantaranya sempat terkendala, namun tetap bisa dilaksanakan. Maka dari itu, demi menjaga keberlangsungan seluruh program seusai pengabdian diperlukan peran serta pengelola dan para guru secara signifikan. Kata kunci: MDTA, pembelajaran , pembenahan administrasi dan kurikulum
Pengenalan Budidaya Padi System of Rice Intensification (SRI) di Desa Sungai Rangas Kabupaten Banjar
Authors: Santoso Untung , Saputra Riza Adrianoor , Sofyan Antar , Wahdah Rabiatul , Khamidah Noor , Sari Noorkomala , Nugraha Muhammad Imam , Mahendra Muhammad Aulia , Saputra Juanda
Published: March 2022

Desa Sungai Rangas Kabupaten Banjar merupakan salah satu daerah lumbung pangan di Kalimantan Selatan dengan hasil panen padi yang belum optimal karena masih menggunakan metode pertanian konvensional. Hal ini mendasari perlunya pengenalan Sistem pertanian organik dengan metode System of Rice Intensification (SRI) sebagai alternatif dalam pengembangan budidaya padi di Desa Sungai Rangas, tujuannya selain pertanian berbasis ramah lingkungan juga dapat mendukung pertanian berkelanjutan. Kegiatan pengabdian kepada masyarakat dalam rangka mengenalkan SRI kepada petani sasaran Desa Sungai Rangas dilaksanakan pada Rabu, 22 September 2021. Metode kegiatan pengabdian kepada masyarakat yaitu metode ceramah dan diskusi yang didasari oleh hasil observasi permulaan sebagai landasan penentuan tingkat pemahaman dan wawasan petani mengenai budidaya padi metode SRI. Alat pengukuran berupa kuisioner berisi daftar pertanyaan akan manfaat dan pengetahuan materi yang diberikan hal ini bertujuan untuk mengetahui peningkatan pengetahuan peserta kegiatan terhadap materi penyuluhan yang telah diinformasikan. Hasil dari kegitan ini yaitu seluruh peserta penyuluhan di Desa Sungai Rangas mengetahui tentang budidaya padi metode SRI (System of Rice Intensification) sedangkan evaluasi dari kegiatan ini yaitu akomodasi waktu yang lebih banyak dan penambahan acara praktek di persawahan dalam hal mempraktekan cara menaman dengan metode SRI di lahan persawahan Sungai Rangas agar peserta dapat langsung mempraktekannya sehingga dapat mengenali kendala dan tantangan secara langsung dalam menerapkan metode ini. Kedepannya peserta penyuluhan ingin mencoba menerapkan budidaya padi metode SRI di lahan sawah mereka. Kata kunci: sistem tanam, padi, peningkatan hasil, penyuluhan, pertanian berkelanjutan
Dinamika Pergerakan Pembentukan Keilmuan Geografi di Universitas Lambung Mangkurat Tahun 2013-2019
Authors: Nasruddin Nasruddin
Published: March 2022

Pembentukan ilmu sejatinya adalah upaya membangun karakter bangsa, hal ini sejalan dengan tulisan pada Majalah Swantara Lemhanas RI No. 12 Tahun IV/Maret/2015 berjudul “revolusi mental” bahwa pembangunan karakter bangsa, merupakan upaya kolektif-sistemik suatu negara kebangsaan untuk mewujudkan kehidupan berbangsa dan bernegara yang sesuai dengan dasar dan ideologi, konstitusi, haluan negara, serta potensi kolektifnya dalam konteks kehidupan nasional, regional, dan global yang berkeadaban untuk membentuk bangsa yang tangguh, kompetitif, berakhlak mulia, bermoral, bertoleran, bergotong royong, patriotik, Berbudaya, dan dinamis Pengetahuan dan teknologi berdasarkan Pancasila dan dijiwai oleh iman dan takwa kepada Tuhan Yang Maha Esa. Pembangunan karakter bangsa dilakukan secara koheren melalui proses sosialisasi, pendidikan dan pembelajaran, pemberdayaan, pembudayaan, dan kerjasama seluruh komponen bangsa dan negara. Tujuan penulisan yaitu: (1) menganalisis Pergerakan pembentukan Fakultas Geografi dan Lingkungan Tahun 2013-2018, (2) menganalisis faktor-faktor kegagalan pembentukan Program Studi Geografi Tahun 2018 dan (3) menganalisis faktor-faktor pembentukan pembentukan Program Studi Geografi Tahun 2019 di ULM. Metode yang adalah analisis dekriptif terhadap periodisasi pergerakan pembentukan ilmu pengetahuan Universitas Lambung Mangkurat dari Tahun 2013-2019 Analisis terhadap kajian pembentukan penjelasan bahwa (1) pembentukan Fakultas Geografi dan Lingkungan di ULM secara kelambagaan mendapatkan apresiasi yang tinggi dari berbagai pemangku kepentingan di daerah maupun nasional. Kegagalan ditentukan oleh faktor internal dan ULM, diantaranya: (1) proses eksternal kegiatan seperti Prodi Pendidikan Geografi, FKIP ULM berlangsung dalam waktu yang cukup lama dan menguras energi, (2) terjadinya pembelahan kelompok antara pro dan kontra internal Prodi Pendidikan Geografi terhadap Prodi Pendidikan Geografi sebagai prodi rintis, (3) Lamanya proses internal berdampak pada kemunduran dalam pengajuan hingga terbitnya draft surat edaran moratorium pembentukan baru di lingkungan PTN se-Indonesia. Kegagalan pada proposal Prodi Geografi pada 2018, disebabkan oleh faktor: (1) proses administrasi terkait ULM induk kelembagaan Prodi Geografi, dan baru disetujui pada tanggal 28 Mei 2018 yakni di FISIP ULM (2) proses sidang senat Universitas Lambung Mangkurat,Kata Kunci : Dinamika, Pembentukan Keilmuan Geografi, ULM
Tingkat Kesukaan Tikus Terhadap Berbagai Umpan Pada Perangkap Semi Otomatis
Authors: Mamudah Mahmudah , Pramudi M Indar , Marsuni Yusriadi
Published: March 2022

Tikus sawah dapat dikendalikan dengan pengendalian biologi, kultur teknis, fisik mekanik ataupun kimia, adapun cara yang paling efektif dan efesien yaitu menggunakan perangkap, selain mengurangi pencemaran lingkungan. Metode ini juga aman dan ekonomis serta dapat digunakan berulang kali. Pengendalian ini juga menggunakan umpan untuk menarik masuknya tikus, umpan yang digunakan kepiting sawah, ikan asin tongkol, kelapa bakar, kelapa sangrai dan terasi.   Penelitian ini bertujuan untuk mengetahui umpan yang mampu menarik perhatian tikus sawah pada alat perangkap semi otomatis dan manfaat dapat memberikan informasi bagi petani untuk mengatasi hama tikus sawah dengan memanfaatkan umpan untuk menarik masuknya tikus pada perangkap. Metode penelitian yang dilakukan menggunakan percobaan Rancangan Acak Lengkap (RAL) satu faktor dengan 5 perlakuan. Hasil penelitian menunjukan perlakuan setiap umpan dilihat secara statistik tidak berpengaruh nyata akan tetapi umpan yang disukai tikus sawah yaitu umpan kelapa bakar dan kelapa sangrai. Umpan ini dapat memerangkap tiga spesies tikus yaitu Rattus exulans, Rattus rattus diardii dan Rattus argentiventer.
Pengaruh Insektisida Nabati Daun Galam (Melaleuca cajuputi roxb.) Terhadap Serangan Hama Perusak Daun Pada Tanaman Sawi
Authors: Taopik Mohammad , Soedijo Samharinto , Rosa Helda Orbani
Published: March 2022

Produktivitas  Sawi  (Brassica  juncea  L.)  di  Indonesia  mengalami  peningkatan  pada  tahun  2015-2018,  sejalan  dengan  peningkatan  kebutuhan  masyarakat  akan  sayuran  ini.  Salah satu hambatan dalam  budidaya  sawi  yaitu  serangan  hama  perusak  daun.  Solusi  altenatif  untuk  mengendalikan  hama yaitu   menggunakan  bahan  alami  dari  tumbuhan  galam  (Melaleuca  cajuputi Roxb.).  Tujuan penelitian ini untuk melihat  pengaruh  insektisida  daun  galam  untuk  menekan  hama  perusak  daun  pada  tanaman  sawi.  Penelitian  menggunakan  ekstrak  daun  galam  segar  sebagai  bahan  utama  pembuatan  insektisida  nabati,  yang  diaplikasikan  dengan  berbagai  dosis.  Penelitian  bertempat  di  pertanaman  sayuran  Kelurahan  Guntung  Payung  Kecamatan  Loktabat  Utara  Banjarbaru  dan  dilaksanakan  selama  40  hari  dari  penyemaian  sampai  panen.  Penelitian  ini  menggunakan  metode  percobaan  dengan  Rancangan  Acak  Lengkap  (RAL)  satu  faktor  yang  terdiri  dari  5  perlakuan  konsentrasi  dan  2  kontrol  dengan  4  ulangan.  Hasil  penelitian  menunjukan  berpengaruh  sangat  nyata  untuk  intensitas  serangan  hama  pada  pengamatan  ke  4.  Intensitas  serangan  hama  perusak  daun  sawi  dari yang  tertinggi  sampai yang terendah  berturut-turut  ditunjukkan  oleh  perlakuan  Kontrol  air  (K)  sebesar  26,6%,  Ekstrak  daun  galam  10%  (G5)  21,3%,  Ekstrak  daun  galam  6%  (G3)  20,5%,  Ekstrak  daun  galam  8%  (G4)  17,7%,  Ekstrak  daun  galam  2%  (G1)  15,3%,  Ekstrak  daun  galam  4%  (G2)  14,2%  dan  Kontrol  kimia  (M)  7,9%.
Fabrication Methods of the Polygonal Masonry of Large Tightly Fitted Stone Blocks with Curved Surface Interfaces in Megalithic Structures of Peru
Authors: Lapshin Rostislav
Published: March 2022

The article suggests methods that allow creating the most complicated type of polygonal masonry found in Peru. This masonry consists of large stone blocks weighing from several hundred kilograms to several tons fitted close to each other almost without a gap between complicated curved surfaces over a large area. The work provides a description of techniques, which apparently were used by builders who arrived from Europe. The techniques under discussion are based on the use of a reduced clay model, 3D-pantograph, topography translator and replicas. The use of a reduced clay model and a pantograph provides not only the unique appearance and high quality of masonry with large blocks, but also allows to significantly increase the productivity of the builders. As machines coping-scaling three-dimensional objects are known since the beginning of the 18th century, the stone structures under consideration should be dated by that and later time. The remaining simpler types of polygonal masonry with smaller stones or fitted surfaces are almost flat, or stones contact with each other by a small area, or there are significant gaps between stones, are quite consistent with the well-known methods of stone processing of those and earlier years, and, therefore, they do not require any additional explanations.
Nucleic Acid Liquid Biopsies in Alzheimer’s Disease: Current State, Challenges, and Opportunities
Authors: Soelter Tabea M. , Whitlock Jordan H. , Williams Avery S. , Hardigan Andrew A. , Lasseigne Brittany N.
Published: March 2022

Alzheimer’s disease is the most common neurodegenerative disease and affects persons of all races, ethnic groups, and sexes. The disease is characterized by neuronal loss leading to cognitive decline and memory loss. There is no cure and the effectiveness of existing treatments is limited and depends on the time of diagnosis. The long prodromal period, during which patients’ ability to live a normal life is not affected despite neuronal loss, often leads to a delayed diagnosis because it can be mistaken for normal aging of the brain. In order to make a substantial impact on AD patients, early diagnosis may provide a greater therapeutic window for future therapies to slow AD-associated neurodegeneration. Current gold standards for disease detection include magnetic resonance imaging and positron emission tomography scans, which visualize amyloid β and phosphorylated tau depositions and aggregates. Liquid biopsies, already an active field of research in precision oncology, are hypothesized to provide early disease detection through minimally or non-invasive sample collection techniques. Liquid biopsies in Alzheimer’s disease have been studied in cerebrospinal fluid, blood, ocular, oral, and olfactory fluids. However, most of the focus has been on blood and cerebrospinal fluid due to biomarker specificity and sensitivity attributed to the effects of the blood-brain barrier and inter-laboratory variation during sample collection. Many studies have identified amyloid β and phosphorylated tau levels as putative biomarkers, however, advances in next-generation sequencing-based liquid biopsy methods have led to significant interest in identifying nucleic acids species associated with Alzheimer’s disease from liquid tissues. Differences in cell-free RNAs and DNAs have been described as potential biomarkers for AD and hold the potential to affect disease diagnosis, treatment, and future research avenues.
Considerations and Challenges for Sex-Aware Drug Repurposing
Authors: Fisher Jennifer , Jones Emma , Flanary Victoria , Williams Avery , Ramsey Elizabeth , Lasseigne Brittany
Published: March 2022

Sex differences are essential factors in disease etiology and manifestation in many diseases such as cardiovascular disease, cancer, and neurodegeneration (1). The biological influence of sex differences (including genomic, epigenetic, hormonal, immunological, and metabolic differences between males and females) and the lack of biomedical studies considering sex differences in their study design has led to several policies. For example, the National Institute of Health’s (NIH) sex as a biological variable (SABV) and Sex and Gender Equity in Research (SAGER)) policies to motivate researchers to consider sex differences (2). However, drug repurposing, a promising alternative to traditional drug discovery by identifying novel uses for FDA-approved drugs, lacks sex-aware methods that can improve the identification of drugs that have sex-specific responses (1,3–5). Sex-aware drug repurposing methods either select drug candidates that are more efficacious in one sex or deprioritize drug candidates based on if they are predicted to cause a sex-bias adverse event (SBAE), unintended therapeutic effects that are more likely to occur in one sex. Computational drug repurposing methods are encouraging approaches to develop for sex-aware drug repurposing because they can prioritize sex-specific drug candidates or SBAEs at lower cost and time than traditional drug discovery. Sex-aware methods currently exist for clinical, genomic, and transcriptomic information (3,6,7). They have not expanded to other data types, such as DNA variation, which has been beneficial in other drug repurposing methods that do not consider sex (8). Additionally, some sex-aware methods suffer from poorer performance because a disproportionate number of male and female samples are available to train computational methods (3). However, there is development potential for several different categories (i.e., data mining, ligand binding predictions, molecular associations, and networks). Low-dimensional representations of molecular association and network approaches are also especially promising candidates for future sex-aware drug repurposing methodologies because they reduce the multiple hypothesis testing burden and capture sex-specific variation better than the other methods (9,10). Here we review how sex influences drug response, the current state of drug repurposing including with respect to sex-bias drug response, and how model organism study design choices influence drug repurposing validation.
A Mixed Methods Investigation of LGBTQ+ Victimization, Its Relationship to LGBTQ+ Identity Development, and the Buffering Potential of Social Support and Outness
Authors: Kiperman Sarah , Schacter Hannah , Judge Margaret , DeLong Gabriel
Published: March 2022

Research rarely explores LGBTQ+ youth bullying in the context of culture-specific outcomes (e.g., LGBTQ+ identity development) and what can mitigate the impact of peer stressors. This study used a concurrent mixed methods design to explore how experiences of peer victimization predicted LGBTQ+ youth’s identity development (i.e., stigma sensitivity, concealment motivation, and difficult process) and whether social support and outness served as protective, moderating factors. The mixed-methods approach provides a culture-specific context via qualitative inquiry to inform whether the quantitative findings align with how youth qualitatively discuss their experience of bullying, negative outcomes, and social support. Our sample consisted of 349 LGBTQ+ youth 14-17 years old who completed a survey (quantitative sample), and a subset of 39 LGBTQ+ youth who completed a semi-structured interview (qualitative sample). Our quantitative findings indicated that greater overall peer victimization was positively related to LGBIS-revised subscales of stigma sensitivity, concealment motivation, and difficult process, where both outness and social support moderated such relations. Qualitatively, victimized youth also reported stigma sensitivity and concealment motivation, while also endorsing how being out and having a support system played a role in their experience of being victimized. These qualitative findings align with our quantitative findings that classmate support mitigated the effects of peer victimization on difficulty of coming out. Implications for practitioners and researchers are provided.
Evolution of Therapeutic Patient Education: A Systematic Scoping Review and Scientometric Analysis
Authors: Correia Jorge César , Waqas Ahmed , Aujoulat Isabelle , Davies Melanie J , Assal Jean-Philippe , Golay Alain , Pataky Zoltan
Published: March 2022

Therapeutic patient education (TPE) aims to empower the patients and their caregivers to effectively care for and manage their conditions. Such educational programs have been shown to improve health behaviors, disease outcomes and quality of life among different patient populations. The field of TPE has evolved extensively over decades, owing to interdisciplinary research. No study so far has been done to map this field, to identify the stakeholders and gaps requiring future research. By leveraging the theory of co-citation, Citespace was used to visualize the bibliographic data pertaining to TPE research. A total of 54,533 articles published in English language were analyzed to identify influential funders, regions and institutes contributing to this field. Besides these, important theoretical and empirical work that has shaped this field has also been mapped. Our analysis revealed several important insights. Most of the important theories which helped shape TPE were inspired from the social sciences. Five important themes of research were identified including disorders, study designs utilized in TPE research, scope of the TPE literature, and outcomes, and populations. The research focused on improving perceptions, behaviors, and attitudes for health promotion, reducing stigma as well as self-management and medication adherence. Most of the research was developed in the context of high income countries. The future research should more involve patients and use digital technology. Meta-analytical studies need to be done to identify the specificities of TPE interventions across different disorders. More research should involve low and middle income countries (LMIC) to ensure knowledge and technology transfer.
Hubungan Pola Makan, Aktivitas Fisik dan Konsumsi Fast Food terhadap Kejadian Gizi Lebih pada Remaja
Authors: Cahyorini Rutnia Widyaning , Komalyna I Nengah Tanu , Suwita I Komang
Published: March 2022

Overnutrition in adolescents is a nutritional state that exceeds normal limits for a long time marked by excess body weight, this is closely related to behavioral factors such as diet and lifestyle. The impact of excess nutrition is type 2 diabetes mellitus, hypertension, coronary heart disease, cancer. Alternative efforts to deal with overnutrition in adolescents require a national strategy related to diet and physical activity. The purpose of this study was to analyze the relationship between diet, physical activity, consumption of fast food on overnutrition in adolescents. The method used is the literature review study of journal articles that meet the inclusion and exclusion requirements in the search database using google scholar, crossref, Indonesia one search and the Garuda portal using the keywords: diet, physical activity and consumption of fast food on Overnutrition in adolescents. The results of the study were as many as 13 articles studied, the condition of eating patterns in adolescents who experienced nutrition were more likely to choose foods with high energy content (meatballs, batagor, bread and carbonated drinks) with a frequency of 4 to 7 times a day and in large quantities (energy adequacy level 130% RDA/ Recommended Dietary Allowance) with physical activity included in the light category (watching TV or doing sports < 3 times per week). Undernourished adolescents are more likely to frequently (> 3 times per week) consume fast food. The conclusion is that there is a significant relationship between diet, physical activity and consumption of fast food on overnutrition in adolescents.
Pemetaan Data Usaha Mikro Kecil dan Menengah dan Pendaftaran Nomor Induk Berusaha di Desa Tremes, Kecamatan Sidoharjo, Kabupaten Wonogiri, Jawa Tengah
Authors: Arsanto Dany Farel Ega , Arifa Aulia , Calosa Aditya Bagas , Yulianto Bagas , Wibowo Devi Novitasari Putri , Meisari Dwi , Pramesti Endika Sofya , Mahdafikia Gaizka , Luthfiyah Qonita , Azizah Ranita Restu Nur , Mujiyo Mujiyo
Published: March 2022

Business Registration Number (BRN) is the identity of business actors in the context of carrying out business activities according to their business fields. NIB is important for business actors to take care of matters regarding business licensing. One of the purposes of NIB ownership is to provide convenience in obtaining capital assistance and business development. Data mapping activities for Micro, Small and Medium Enterprises (MSMEs) and registration of Business Identification Numbers (NIB) were carried out in Tremes Village, District, Sidoharjo District, Wonogiri Regency. The low NIB ownership of business actors in Tremes Village, while the high number of MSMEs encourages this activity. Activities are carried out by 1) socialization; 2) data input training using https://oss.go.id in direct partnership with the Investment and One Stop Service Office; 3) distribution and collection of forms; 4) data input and issuance of Business Registration Number (BRN) and; 5) submission of the Business Registration Number (BRN) to the public. This activity aims to map data and help manage micro, small and medium enterprises. Mapping of MSMEs data in Tremes Village makes it easier for the village government to get MSMEs data and facilitates the process of distributing MSMEs assistance on target. The total number of MSMEs that have been recorded in Tremes Village is 459 businesses. There were 454 BRNs (99.34%) of the 457 MSMEs that registered. Follow-up from the issuance of the BRN in Tremes Village was the submission of Productive Micro Business Assistance to the Office of Cooperatives, Small Medium Enterprises, Industry and Trade, Wonogiri Regency.
Implementation of Safe Supply Alternatives During Intersecting COVID-19 and Overdose Health Emergencies in British Columbia, Canada, 2021
Authors: McNeil Ryan , Fleming Taylor , Mayer Samara , Barker Allison , Mansoor Manal , Betsos Alex , Austin Tamar , Parusel Sylvia , Ivsins Andrew , Boyd Jade
Published: March 2022

Objectives. To explore the implementation and effectiveness of the British Columbia, Canada, risk mitigation guidelines among people who use drugs, focusing on how experiences with the illicit drug supply shaped motivations to seek prescription alternatives and the subsequent impacts on overdose vulnerability.

Methods. From February to July 2021, we conducted qualitative interviews with 40 people who use drugs in British Columbia, Canada, and who accessed prescription opioids or stimulants under the risk mitigation guidelines.

Results. COVID-19 disrupted British Columbia’s illicit drug market. Concerns about overdose because of drug supply changes, and deepening socioeconomic marginalization, motivated participants to access no-cost prescription alternatives. Reliable access to prescription alternatives addressed overdose vulnerability by reducing engagement with the illicit drug market while allowing greater agency over drug use. Because prescriptions were primarily intended to manage withdrawal, participants supplemented with illicit drugs to experience enjoyment and manage pain.

Conclusions. Providing prescription alternatives to illicit drugs is a critical harm reduction approach that reduces exposure to an increasingly toxic drug supply, yet further optimizations are needed. (Am J Public Health. 2022;112(S2):S151–S158. https://doi.org/10.2105/AJPH.2021.306692 )
Bone Block Grafting for Posterior Instability After Anatomical Total Shoulder Arthroplasty
Authors: Matsumoto Ryo , Matsumura Noboru , Furuhata Ryogo , Kimura Hiroo , Suzuki Taku , Iwamoto Takuji , Matsumoto Morio , Nakamura Masaya
Published: March 2022

Case:

A 60-year-old woman with avascular necrosis of the right humeral head underwent anatomical total shoulder arthroplasty (TSA); however, recurrent posterior dislocation occurred 13 months postoperatively. We performed bone block grafting of an autologous iliac crest to the posterior glenoid and posterior capsular plication, after which satisfactory postoperative shoulder function without residual joint instability was achieved.

Conclusion:

The presented case had recurrent posterior dislocation after TSA without any abnormal findings in the prosthetic components. Posterior bone block grafting with capsular plication should be considered a viable option for posterior instability after anatomical TSA.
Determinants of National Health Insurance Enrolment Among People at Risk of Statelessness in Ghana
Authors: Quartey Theophilus , Peprah Charles , Morgan Anthony Kwame
Published: March 2022

Background: This paper investigates the factors influencing the decision to enrol in Ghana’s National Health Insurance Scheme (NHIS) among people at risk of statelessness, with emphasis on individuals’ demographic and socio-economic factors. Methods: The study used data from a cross-sectional household survey undertaken in Ghana's Central Region between March 9 and June 26, 2021, on healthcare utilization culture among people at risk of statelessness. Descriptive statistics and binary logistic regression were used in analysing data from a sample of 384 people at risk of statelessness from the Awutu Senya East Municipality and the Gomoa East District of Ghana’s Central Region. Results: The results reveal that about 51% have ever enrolled while 48% of participants were enrolled on the NHIS at the time of the survey (active members). The majority of the enrolled members acquired their membership through self-payment of the enrolment fee. Additionally, increasing age was associated with lower odds of enrolling, while lower age was associated with higher odds of enrolling in the health insurance. Also, persons who are married and have secondary education or an equivalent qualification were more likely to enrol, while persons with no employment were less likely to enrol. Conclusion: According to the paper, while the gap in coverage between rich and poor, married and single appears to have narrowed, these factors continue to determine NHIS coverage among people at risk of statelessness. The same is true for education. Efforts must be increased to ensure equal access to healthcare.
Practical Guidance for Running Late-Phase Platform Protocols for Clinical Trials: Lessons From Experienced UK Clinical Trials Units
Authors: Love Sharon B , Cafferty Fay , Snowdon Claire , Carty Karen , Savage Joshua , Pallmann Philip , McParland Lucy , Brown Louise , Masters Lindsey , Schiavone Francesca , Hague Dominic , Townsend Stephen , Amos Claire , South Annabelle , Sturgeon Kate , Langley Ruth , Maughan Timothy , James Nicholas , Hall Emma , Kernaghan Sarah , Bliss Judith , Turner Nicholas , Yap Christina , Firth Charlotte , Kong Anthony , Mehanna Hisham , Watts Colin , Hills Robert , Thomas Ian , Copland Mhairi , Bell Sue , Tutt Andrew , Montefiore David Sebag- , Jones Robert , Parmar Mahesh KB , Sydes Matthew R
Published: March 2022

Background
Late-phase platform protocols (including basket, umbrella, multi-arm multi-stage (MAMS), and master protocols) are generally agreed to be more efficient than traditional two-arm clinical trial designs but are not extensively used. We have gathered the experience of running a number of successful platform protocols together to present some operational recommendations.
Methods
Representatives of six UK clinical trials units with experience in running late-phase platform protocols attended a one-day meeting structured to discuss various practical aspects of running these trials. We report and give guidance on operational aspects which are either harder to implement compared to a traditional late-phase trial or are specific to platform protocols.
Results
We present a list of practical recommendations for trialists intending to design and conduct late-phase platform protocols. Our recommendations cover the entire life cycle of a platform trial: from protocol development, obtaining funding, and trial set-up, to a wide range of operational and regulatory aspects such as staffing, oversight, data handling, and data management, to the reporting of results, with a particular focus on communication with trial participants and stakeholders as well as public and patient involvement
Discussion
Platform protocols enable many questions to be answered efficiently to the benefit of patients. Our practical lessons from running platform trials will support trial teams in learning how to run these trials more effectively and efficiently.
Process optimization in Poultry Feed Mill
Authors: Amin Sameh , Sobhi Nahed
Published: March 2022

Poultry feed industry is a pretty much active in a lot of countries and it is achieved market acceptance. The final products are supposed to meet certain specifications to fulfill the nutritional need for animals at different life periods. The final product for poultry is shipped in the form of pelleted feed for the convenience of consumption. This paper focuses on improving production rates while maintaining quality specifications of the final products in an Egyptian poultry feed factory. The improvement approach is conducted by observing the main operating parameters of productivity; statistical analysis is conducted to observe the effect of those parameters on the production rate and the quality of the product. Comparison between parameters levels is done through analysis of variance to determine the significance of the tested parameters. The optimization of parameters was applied with Minitab and designed expert software to determine the best operating conditions. The obtained results showed that the downtime decreases by 16% monthly and the productivity increased by 35% and the pellet durability index increased by 0.8% after applying these parameters with total saving 2,160,000 LE.
Visual identification and pose estimation algorithm of nut tightening robot system
Authors: Zhou Yibang , Wang Xiaoyong , Zhang Lanzhu
Published: March 2022

To realize the automatic tightening of nuts, a nut tightening robot system strategy based on machine vision was designed in this work. The strategy was based on three stages: nut image calibration, nut identification and nut pose estimation. In the first stage, the template pose image of the nut and the coordinates of the nut center in this nut image were obtained by calibration. In the second stage, a nut identification algorithm based on improved the backbone feature extraction network and area generation network of Faster-RCNN was presented, which improved the efficiency and accuracy of nut identification. In the last stage, a nut pose estimation algorithm based on Fourier and log-polar coordinate transformation was presented to solve the rotation angle, translation and scale of the nut relative to the template nut image, and then obtain the rotation angle of the sleeve and the central coordinate of the nut. An experimental nut tightening robot platform was also set up in this work. The results of 50 tests showed that the proposed detection methods could identify nuts with 100% accuracy, and with this proposed pose estimation methods the average error of the rotation angle of the nut was 0.057, the average error of the center position of the nut in and directions was and of direction was . The experimental results showed that the nut tightening robot scheme and algorithm designed in this work were feasible in nut identification and pose estimation, and met the requirements of insertion accuracy in the process of nut tightening.
Mapping Algorithms For Predicting EQ-5D Utilities From The Assessment Test Of Chronic Obstructive Pulmonary Disease
Authors: Yu Chun-Hsiang , Chang Sheng-Mao , Hsu Chih-Hui , Tsai Sheng-Han , Liao Xin-Min , Chen Chang-Wen , Lin Ching-Hsiung , Wang Jung-Der , Hsiue Tzuen-Ren , Chen Chiung-Zuei
Published: March 2022

Objectives: In order to predict the European Quality of Life-5 Dimensions three-Level (EQ-5D-3L) questionnaire utility from the chronic obstructive pulmonary disease (COPD) assessment test (CAT).Methods: The EQ-5D-3L and CAT data from 323 patients were collected. At first, response mapping under a backward elimination procedure was used for the EQ-5D score predictions from the CAT scores. A multinomial logistic regression (MLR) model was used to identify the association between the score and the covariates using a minimized quasi-information criterion (QIC). Afterwards, the predicted scores were transformed to the utility. Validation in the model selection depended on the mean absolute error (MAE) and the root mean squared error (RMSE) for the validation group. We also compared the developed formula with previous models based on an ordinary least squares (OLS) regression. Results: Using response mapping with the MLR model to predict EQ-5D utility from CAT in this study performed as well as OLS regression models in previous studies using MAE and RMSE evaluations (all MAEs ≤ 0.100). In addition, the overestimation for low utility patients (utility ≤ 0.6) and underestimation for near health (utility > 0.9) in previous developed OLS models was improved in this study using a bubble chart analysis. Conclusions: Response mapping with the MLR model led to performance comparable to that using the OLS model for predicting EQ-5D utility from CAT data. In addition, the bubble charts revealed that the model constructed in this study was a better predictive model than other alternatives.