bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparing Graduates to Meet the Allied Health Workforce Needs in Rural Australia: Short-Term Outcomes from a Longitudinal Study
Authors: Brown Leanne , Smith Tony , Wakely Luke , Little Alexandra , Wolfgang Rebecca , Burrows Julie
Published: June 2017

The future allied health workforce needs to be flexible to meet the needs of an ageing population with increasing chronic health care needs and geographically dispersed populations in many developed countries. Existing research shows the maldistribution of the Australian health workforce, with allied health professionals being poorly represented in rural and remote areas. This mixed-methods longitudinal workforce outcomes study is ongoing to determine the rural and remote allied health workforce outcomes from an immersive student placement program based in rural New South Wales, Australia. Outcomes, to date, show 52% of graduates working in a rural or remote area (RA2–RA5) after one year and 37.5% at three years post-graduation. Students from a rural or remote background were 2.35 times (95% CI 1.056–5.229) more likely to be located in a rural or remote workplace after one year than graduates from a metropolitan background. Graduates provided reasons for their plans to move from or stay in their current position. Four key themes emerged: Seeking new and different opportunities; Better income and job security; Personal change and lifestyle improvement and Level of job satisfaction. An existing program to develop the allied health workforce in rural Australia is demonstrating positive short-term outcomes. Ongoing monitoring of workforce outcomes is required to determine the long-term outcomes for rural and remote communities.
A Galvanic Intrabody Method for Assessing Fluid Flow in Unilateral Lymphoedema
Authors: Asogwa Clement , Aryo Bay Johanis , Mclaughlin Patrick , Collins Stephen , Lai Daniel
Published: June 2017

Lymphoedema is a disease associated with abnormal functioning of the lymph that leads to swelling of the body due to accumulation of tissue fluid on the affected area. Tissue fluid contains ions and electrolytes that affect electrical conductivity. The flow of tissue fluid helps to distribute vital nutrients and other important elements necessary for healthy living. When tissue fluid is stagnated, a high concentration of electrolytes accumulate on the affected area, which in turn affects an electrical signal passing through that area to be minimally attenuated in relation to a free-flowing fluid. We demonstrate that a galvanic coupled signal propagating along a lymphoedema affected limb could capture these changes by the amount of attenuation the propagating signal experiences in time. Our results show that average rate of signal attenuation on a lymphoedema affected part of the body could be as slow as 0.16 dB/min, while the rate of signal attenuation on a healthy part is as high as 1.83 dB/min. This means that fluid accumulation could slow down the exchange of body electrolytes up to twice less the rate on an unaffected contralateral part of the body. Monitoring these changes by observing the average rate of change of a galvanic coupled signal attenuation on the affected body part can be used for diagnosing early developments of oedema in the body and for evaluating recovery in response to treatment procedures.
A Multiconductor Model of Power Line Communication in Medium-Voltage Lines
Authors: Franek Lesek , Fiedler Petr
Published: June 2017

Most power line communication (PLC) models are designed to date simulate power lines as two-wire lines. However, in alternating current (AC) electrical distribution, the two-wire option is seldom applied, and medium-voltage lines are most often based on the three-phase configuration. In this context, the influence of the ground, which constitutes another conductor with specific parameters, cannot be neglected. Two-wire models are characterized by limited accuracy, not allowing us to simulate certain major phenomena affecting PLC. This, for example, could embody the answer to the question of whether it is more advantageous to transmit a signal independently through each phase, reference the signal with respect to another phase or to use the ground as a reference. This paper discusses a multi-conductor model that eliminates the disadvantages outlined above; the proposed model exploits the multi-conductor telegrapher’s equations. In order to be able to include medium-voltage (MV)/ low-voltage (LV) transformers in medium-voltage network models, we constituted a transformer model. The designed models were validated on a real medium-voltage network. To be able to evaluate the suitability of the PLC, the noise in the medium voltage network was measured in order to determine the signal-to-noise ratio (SNR).
Advances in Mid-IR Fiber Lasers: Tellurite, Fluoride and Chalcogenide
Authors: Falconi Mario , Laneve Dario , Prudenzano Francesco
Published: June 2017

A review on the recent progress in modeling and fabrication of medium infrared (Mid-IR) fiber lasers is reported. The main objective is to illustrate some recent examples of continuous wave optical sources at wavelengths longer than those commonly employed in telecom applications and allowing high beam quality. A small number of Mid-IR lasers, among the large variety of schemes, glasses, dopants and pumping schemes reported in literature, is selected on the basis of their slope efficiency and threshold pump power. In particular, tellurite, fluoride and chalcogenide fiber lasers are considered. More details are given with reference to the novel pumping schemes.
Investigating Gender on the Frontier: 19th-Century Crooked Creek Cemetery
Authors: Schroer Sandra , Hine Ellen
Published: June 2017

This qualitative case study highlights the work of university students who participated in a service learning component of a sociological research methods course. Their complete documentation and analysis of all 477 gravestones in the abandoned Crooked Creek cemetery provide a cultural snapshot of life in the Western frontier in the 1800s. In contrast to existing literature on the analysis of gender indicators on gravestones, this study finds significant evidence that gender was related to social identity and that indicators of master status exist for both women and men. Furthermore, the significant role of women in the development of a pioneer village is represented in the epitaphs chosen by a woman’s surviving family members. The findings attempt to dispel assumptions that the use of terms such as “wife” and “mother” on gravestones of the period exemplified the lower status of women in relation to men. Implications for genealogical research include rethinking the way researchers consider the role of wife and mother to write more historically situated narratives of family and community histories.
Investigation of Acute Pulmonary Deficits Associated with Biomass Fuel Cookstove Emissions in Rural Bangladesh
Authors: Medgyesi Danielle , Holmes Heather , Angermann Jeff
Published: June 2017

The use of solid biomass fuels in cookstoves has been associated with chronic health impacts that disproportionately affect women worldwide. Solid fuel stoves that use wood, plant matter, and cow dung are commonly used for household cooking in rural Bangladesh. This study investigates the immediate effects of acute elevated cookstove emission exposures on pulmonary function. Pulmonary function was measured with spirometry before and during cooking to assess changes in respiratory function during exposure to cookstove emissions for 15 females ages 18–65. Cookstove emissions were characterized using continuous measurements of particulate matter (PM2.5—aerodynamic diameter <2.5 μm) concentrations at a 1 s time resolution for each household. Several case studies were observed where women ≥40 years who had been cooking for ≥25 years suffered from severe pulmonary impairment. Forced expiratory volume in one second over forced vital capacity (FEV1/FVC) was found to moderately decline (p = 0.06) during cooking versus non-cooking in the study cohort. The study found a significant (α < 0.05) negative association between 3- and 10-min maximum PM2.5 emissions during cooking and lung function measurements of forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and FEV1/FVC obtained during cooking intervals. This study found that exposure to biomass burning emissions from solid fuel stoves- associated with acute elevated PM2.5 concentrations- leads to a decrease in pulmonary function, although further research is needed to ascertain the prolonged (e.g., daily, for multiple years) impacts of acute PM2.5 exposure on immediate and sustained respiratory impairment.
Geospatial Big Data-Based Geostatistical Zonation of Seismic Site Effects in Seoul Metropolitan Area
Authors: Kim Han-Saem , Sun Chang-Guk , Cho Hyung-Ik
Published: June 2017

Seismic site effects are influenced mainly by geospatial uncertainties corresponding to geological or geotechnical spatial variance. Therefore, the development of a geospatial database is essential to characterize site-specific geotechnical information in multiscale areas and to optimize geospatial zonation methods with potentially high degrees of spatial variability based on trial-and-error geostatistical assessments. In this study, a multi-source geospatial information framework, which included the construction of a big data platform, estimation of geostatistical density, optimization of the geostatistical interpolation method, assessment of seismic site effects, and determination of geospatial zonation for decision making, was established. Then, this framework was applied to the Seoul metropolitan area, South Korea. The GIS-based framework was established to develop the geospatial zonation of site-specific seismic site effects before considering the local characteristics of site effects dependent on topographic or geological conditions, based on a geospatial big-data platform in Seoul. The zonal conditions were composed of geo-layers, site effect parameters, and other multi-source geospatial maps for each administrative area, and infrastructure was determined based on the integration of the optimized geoprocessing framework.
Lipid Storage and Autophagy in Melanoma Cancer Cells
Authors: Giampietri Claudia , Petrungaro Simonetta , Cordella Martina , Tabolacci Claudio , Tomaipitinca Luana , Facchiano Antonio , Eramo Adriana , Filippini Antonio , Facchiano Francesco , Ziparo Elio
Published: June 2017

Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere-derived CSC to differentiating melanosphere-derived cells. Increased lipid uptake was found in melanosphere-derived CSC vs. differentiating melanosphere-derived cells, paralleled by strong expression of lipogenic factors Sterol Regulatory Element-Binding Protein-1 (SREBP-1) and Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ). An inverse relation between lipid-storing phenotype and autophagy was also found, since microtubule-associated protein 1A/1B-Light Chain 3 (LC3) lipidation is reduced in melanosphere-derived CSC. To investigate upstream autophagy regulators, Phospho-AMP activated Protein Kinase (P-AMPK) and Phospho-mammalian Target of Rapamycin (P-mTOR) were analyzed; lower P-AMPK and higher P-mTOR expression in melanosphere-derived CSC were found, thus explaining, at least in part, their lower autophagic activity. In addition, co-localization of LC3-stained autophagosome spots and perilipin-stained lipid droplets was demonstrated mainly in differentiating melanosphere-derived cells, further supporting the role of autophagy in lipid droplets clearance. The present manuscript demonstrates an inverse relationship between lipid-storing phenotype and melanoma stem cells differentiation, providing novel indications involving autophagy in melanoma stem cells biology.
Effects of the Approximations Embodied in the Momentum Theory as Applied to the NREL PHASE VI Wind Turbine
Authors: Bontempo Rodolfo , Manna Marcello
Published: June 2017

This paper investigates the impact of the standard approximations embodied in the well-known Momentum Theory on its performance prediction capabilities. To this aim, the results of the momentum theory, which is still widely used in all Blade Element/Momentum codes for the analysis and/or design of wind turbines, are compared with those obtained with an actuator disk model based on Computational Fluid Dynamics techniques. In this method, the axisymmetric and steady Euler equations are solved with a classical finite volume approach, while the turbine effects are modelled through a set of axial and tangential body forces distributed over a disk shaped region representing the rotor swept surface. Since this method does not rely on the momentum theory simplifying assumptions, it can be suitably employed to verify the momentum theory validity. The analysis is carried out using the well documented experimental data of the National Renewable Energy Laboratory Phase VI wind turbine.
Microstructure and Dielectric Properties of LPCVD/CVI-SiBCN Ceramics Annealed at Different Temperatures
Authors: Li Jianping , Zhao Mingxi , Liu Yongsheng , Chai Nan , Ye Fang , Qin Hailong , Cheng Laifei , Zhang Litong
Published: June 2017

SiBCN ceramics were introduced into porous Si3N4 ceramics via a low-pressure chemical vapor deposition and infiltration (LPCVD/CVI) technique, and then the composite ceramics were heat-treated from 1400 °C to 1700 °C in a N2 atmosphere. The effects of annealing temperatures on microstructure, phase evolution, dielectric properties of SiBCN ceramics were investigated. The results revealed that α-Si3N4 and free carbon were separated below 1700 °C, and then SiC grains formed in the SiBCN ceramic matrix after annealing at 1700 °C through a phase-reaction between free carbon and α-Si3N4. The average dielectric loss of composites increased from 0 to 0.03 due to the formation of dispersive SiC grains and the increase of grain boundaries.
Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1
Authors: Wang Jing , Kawasaki Ryosuke , Uewaki Jun-ichi , Rashid Arif , Tochio Naoya , Tate Shin-ichi
Published: June 2017

Allosteric communication among domains in modular proteins consisting of flexibly linked domains with complimentary roles remains poorly understood. To understand how complementary domains communicate, we have studied human Pin1, a representative modular protein with two domains mutually tethered by a flexible linker: a WW domain for substrate recognition and a peptidyl-prolyl isomerase (PPIase) domain. Previous studies of Pin1 showed that physical contact between the domains causes dynamic allostery by reducing conformation dynamics in the catalytic domain, which compensates for the entropy costs of substrate binding to the catalytic site and thus increases catalytic activity. In this study, the S138A mutant PPIase domain, a mutation that mimics the structural impact of the interdomain contact, was demonstrated to display dynamic allostery by rigidification of the α2-α3 loop that harbors the key catalytic residue C113. The reduced dynamics of the α2-α3 loop stabilizes the C113–H59 hydrogen bond in the hydrogen-bonding network of the catalytic site. The stabilized hydrogen bond between C113 and H59 retards initiation of isomerization, which explains the reduced isomerization rate by ~20% caused by the S138A mutation. These results provide new insight into the interdomain allosteric communication of Pin1.
The Molecular Effect of Diagnostic Absorbed Doses from 131I on Papillary Thyroid Cancer Cells In Vitro
Authors: Stasiołek Mariusz , Adamczewski Zbigniew , Śliwka Przemysław , Puła Bartosz , Karwowski Bolesław , Merecz-Sadowska Anna , Dedecjus Marek , Lewiński Andrzej
Published: June 2017

Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of a therapeutic dose of 131I. Unfortunately, administration of the radioisotope in a diagnostic dose may decrease further radioiodine uptake—the phenomenon called “thyroid stunning”. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in the sodium iodide symporter (NIS) gene promoter, and the NIS protein level in a K1 cell line derived from the metastasis of a human papillary thyroid carcinoma exposed to 131I in culture. The different activities applied were calculated to result in absorbed doses of 5, 10 and 20 Gy. Radioiodine did not affect the expression of the NIS gene at the mRNA level, however, we observed significant changes in the NIS protein level in K1 cells. The decrease of the NIS protein level observed in the cells subjected to the lowest absorbed dose was paralleled by a significant increase in 8-oxo-dG concentrations (p < 0.01) and followed by late activation of the DNA repair pathways. Our findings suggest that the impact of 131I radiation on thyroid cells, in the range compared to doses absorbed during diagnostic procedures, is not linear and depends on various factors including the cellular components of thyroid pathology.
Energy Payback Time of a Solar Photovoltaic Powered Waste Plastic Recyclebot System
Authors: Zhong Shan , Rakhe Pratiksha , Pearce Joshua
Published: June 2017

The growth of both plastic consumption and prosumer 3-D printing are driving an interest in producing 3-D printer filaments from waste plastic. This study quantifies the embodied energy of a vertical DC solar photovoltaic (PV) powered recyclebot based on life cycle energy analysis and compares it to horizontal AC recyclebots, conventional recycling, and the production of a virgin 3-D printer filament. The energy payback time (EPBT) is calculated using the embodied energy of the materials making up the recyclebot itself and is found to be about five days for the extrusion of a poly lactic acid (PLA) filament or 2.5 days for the extrusion of an acrylonitrile butadiene styrene (ABS) filament. A mono-crystalline silicon solar PV system is about 2.6 years alone. However, this can be reduced by over 96% if the solar PV system powers the recyclebot to produce a PLA filament from waste plastic (EPBT is only 0.10 year or about a month). Likewise, if an ABS filament is produced from a recyclebot powered by the solar PV system, the energy saved is 90.6–99.9 MJ/kg and 26.33–29.43 kg of the ABS filament needs to be produced in about half a month for the system to pay for itself. The results clearly show that the solar PV system powered recyclebot is already an excellent way to save energy for sustainable development.
Integrated, Decentralized Wastewater Management for Resource Recovery in Rural and Peri-Urban Areas
Authors: Capodaglio Andrea
Published: June 2017

Collection and treatment of wastewater have a huge impact on the environment and economy, both at the local and global levels. Eco-innovation may play a paramount role in the reduction of the environmental impact of such systems, and in their greater sustainability in economic, environmental, and social terms. Decentralization appears as a logical solution to tackle sustainability problems of wastewater management systems, as it focuses on the on-site treatment of wastewater and on local recycling and reuse of resources contained in domestic wastewater (in primus, water itself). This paper analyses the needs, technological options and contribution to water management of decentralized systems. Decentralized solutions in general will tend to be compatible with local water use and reuse requirements, where locally treated water could support agricultural productivity or (in more urban areas) be used as a substitute for drinking-quality supply water for compatible uses. In analyzing sustainability of technology, different dimensions should be taken into account (in particular, local issues). There is no fixed or universal solution to the technological issue; to the contrary, all relevant studies demonstrated there are varying degrees of sustainability in the way a technology is selected and operated, to avoid exporting problems over time or space.
Analyzing the Potential Risk of Climate Change on Lyme Disease in Eastern Ontario, Canada Using Time Series Remotely Sensed Temperature Data and Tick Population Modelling
Authors: Cheng Angela , Chen Dongmei , Woodstock Katherine , Ogden Nicholas , Wu Xiaotian , Wu Jianhong
Published: June 2017

The number of Lyme disease cases (Lyme borreliosis) in Ontario, Canada has increased over the last decade, and that figure is projected to continue to increase. The northern limit of Lyme disease cases has also been progressing northward from the northeastern United States into southeastern Ontario. Several factors such as climate change, changes in host abundance, host and vector migration, or possibly a combination of these factors likely contribute to the emergence of Lyme disease cases in eastern Ontario. This study first determined areas of warming using time series remotely sensed temperature data within Ontario, then analyzed possible spatial-temporal changes in Lyme disease risk in eastern Ontario from 2000 to 2013 due to climate change using tick population modeling. The outputs of the model were validated by using tick surveillance data from 2002 to 2012. Our results indicated areas in Ontario where Lyme disease risk changed from unsustainable to sustainable for sustaining Ixodes scapularis (black-legged tick) populations. This study provides evidence that climate change has facilitated the northward expansion of black-legged tick populations’ geographic range over the past decade. The results demonstrate that remote sensing data can be used to increase the spatial detail for Lyme disease risk mapping and provide risk maps for better awareness of possible Lyme disease cases. Further studies are required to determine the contribution of host migration and abundance on changes in eastern Ontario’s Lyme disease risk.
An Extended Kriging Method to Interpolate Near-Surface Soil Moisture Data Measured by Wireless Sensor Networks
Authors: Zhang Jialin , Li Xiuhong , Yang Rongjin , Liu Qiang , Zhao Long , Dou Baocheng
Published: June 2017

In the practice of interpolating near-surface soil moisture measured by a wireless sensor network (WSN) grid, traditional Kriging methods with auxiliary variables, such as Co-kriging and Kriging with external drift (KED), cannot achieve satisfactory results because of the heterogeneity of soil moisture and its low correlation with the auxiliary variables. This study developed an Extended Kriging method to interpolate with the aid of remote sensing images. The underlying idea is to extend the traditional Kriging by introducing spectral variables, and operating on spatial and spectral combined space. The algorithm has been applied to WSN-measured soil moisture data in HiWATER campaign to generate daily maps from 10 June to 15 July 2012. For comparison, three traditional Kriging methods are applied: Ordinary Kriging (OK), which used WSN data only, Co-kriging and KED, both of which integrated remote sensing data as covariate. Visual inspections indicate that the result from Extended Kriging shows more spatial details than that of OK, Co-kriging, and KED. The Root Mean Square Error (RMSE) of Extended Kriging was found to be the smallest among the four interpolation results. This indicates that the proposed method has advantages in combining remote sensing information and ground measurements in soil moisture interpolation.
Study of the Relation between the Resonance Behavior of Thickness Shear Mode (TSM) Sensors and the Mechanical Characteristics of Biofilms
Authors: Castro Pedro , Elvira Luis , Maestre Juan , Montero de Espinosa Francisco
Published: June 2017

This work analyzes some key aspects of the behavior of sensors based on piezoelectric Thickness Shear Mode (TSM) resonators to study and monitor microbial biofilms. The operation of these sensors is based on the analysis of their resonance properties (both resonance frequency and dissipation factor) that vary in contact with the analyzed sample. This work shows that different variations during the microorganism growth can be detected by the sensors and highlights which of these changes are indicative of biofilm formation. TSM sensors have been used to monitor in real time the development of Staphylococcus epidermidis and Escherichia coli biofilms, formed on the gold electrode of the quartz crystal resonators, without any coating. Strains with different ability to produce biofilm have been tested. It was shown that, once a first homogeneous adhesion of bacteria was produced on the substrate, the biofilm can be considered as a semi-infinite layer and the quartz sensor reflects only the viscoelastic properties of the region immediately adjacent to the resonator, not being sensitive to upper layers of the biofilm. The experiments allow the microrheological evaluation of the complex shear modulus (G* = G′ + jG″) of the biofilm at 5 MHz and at 15 MHz, showing that the characteristic parameter that indicates the adhesion of a biofilm for the case of S. epidermidis and E. coli, is an increase in the resonance frequency shift of the quartz crystal sensor, which is connected with an increase of the real shear modulus, related to the elasticity or stiffness of the layer. In addition both the real and the imaginary shear modulus are frequency dependent at these high frequencies in biofilms.
Tunable Temperature Response of a Thermochromic Photonic Gel Sensor Containing N-Isopropylacrylamide and 4-Acryloyilmorpholine
Authors: Kye Hwanam , Koh Young , Kim Youkyung , Han Sung , Lee Hyunjung , Lee Wonmok
Published: June 2017

In this study, thermochromic photonic gels were fabricated using 2-hydroxyethyl methacrylate (HEMA) as a hydrogel building block, and 4-Acryloyl morpholine (ACMO) and N-isopropylacrylamide (NIPAAM) as thermoresponsive monomers with different critical solution temperature behaviors. Rapid photopolymerization of opal-templated monomer mixtures of varying ACMO contents formed five individual thermochromic inverse opal photonic gels integrated on a single substrate. With temperature variation from 10 °C to 80 °C, the changes in reflective colors and reflectance spectra of the respective thermochromic gels were noted, and λpeak changes were plotted. Because NIPAAM exhibits a lower critical solution temperature (LCST) at 33 °C, the NIPAAM-only gel showed a steep slope for dλpeak/dT below 40 °C, whereas the slope became flatter at high temperatures. As the ACMO content increased in the thermochromic gel, the curve of dλpeak/dT turned out to be gradual within the investigated temperature range, exhibiting the entire visible range of colors. The incorporation of ACMO in NIPAAM-based thermochromic gels therefore enabled a better control of color changes at a relatively high-temperature regime compared to a NIPAAM-only gel. In addition, ACMO-containing thermochromic gels exhibited a smaller hysteresis of λpeak for the heating and cooling cycle.
Photoacoustic Drug Delivery
Authors: Zhang Yuqi , Yu Jicheng , Kahkoska Anna , Gu Zhen
Published: June 2017

Photoacoustic (PA) technology holds great potential in clinical translation as a new non-invasive bioimaging modality. In contrast to conventional optical imaging, PA imaging (PAI) enables higher resolution imaging with deeper imaging depth. Besides applications for diagnosis, PA has also been extended to theranostic applications. The guidance of PAI facilitates remotely controlled drug delivery. This review focuses on the recent development of PAI-mediated drug delivery systems. We provide an overview of the design of different PAI agents for drug delivery. The challenges and further opportunities regarding PA therapy are also discussed.
What is Trained Develops! Theoretical Perspective on Skill Learning
Authors: Sigmundsson Hermundur , Trana Leif , Polman Remco , Haga Monika
Published: June 2017

Knowledge about developmental theories is important for experts or specialists working with children following normal development and children who have various kinds of dysfunction, in order to better understand what happens with processes associated with motor behavior. In this article, we have explored how theories of development and learning can be used to understand processes associated with motor behavior. A probabilistic perspective emphasizes that the changes taking place in the development is a result of interaction: structural changes in the nervous system leading to changes in function and behavior and opposite, functional changes resulting in changes in structure. This bidirectional interaction between biological and experiential aspects is a continuous process which cannot be reduced to either organism or environment. Dynamical systems theory (DST) emphasizes that it is the interaction between the person, the environment, and the task that changes how our movements are, also in terms of how we develop and learn new movements. The interplay between these factors will, over time, lead to changes in motor development. The importance of experience is central to Edelman's theory of neuronal group selection (NGST). Activation of the nervous system increases the connections between certain areas of the brain, and the selection processes in the brain are a result of enhancement of neural connections involved in a "successful" motion. The central nervous system adapts its structure and function in response to internal and external influences, and hence neural plasticity is a prerequisite for learning and development. We argue that Edelman´s approach supports the theory of specificity of learning. From the perspectives of probabilistic epigenesis, DST, and NGST, we can see that being physically active and having the opportunity to get different movement experiences are of great significance for promoting motor development and learning. A variation of purposeful or rewarding physical activity in a variety of contexts will provide individual opportunities for changes of behavior in terms of both quantitative and qualitative changes in motor development.
The Role of Indicator-Based Sustainability Assessment in Policy and the Decision-Making Process: A Review and Outlook
Authors: Dizdaroglu Didem
Published: June 2017

In order to regulate natural processes and control the scale of human activities, sustainability assessment needs to be integrated into urban planning. In this context, indicator-based sustainability assessment tools are fundamental instruments that provide information to support policy and decision-making. Indicators are necessary to monitor the implementation of the policies and provide feedback needed to accomplish the desirable state of sustainable urban development. This paper aims to explore the role of indicator-based sustainability assessment in policy and the decision-making process. Therefore, it reviews the identified sustainable development indicator initiatives and addresses the research gaps in the literature for future improvement of sustainability assessment frameworks. It concludes with a discussion that the major problem in sustainability assessment lies in the gathering of reliable and accessible data.
The Effect of Urban Green Infrastructure on Disaster Mitigation in Korea
Authors: Kim So , Kim Brian
Published: June 2017

Increasing precipitation by climate change and the growing number of impervious areas present greater risk of disaster damage in urban areas. Urban green infrastructure can be an effective mitigation alternative in highly developed and concentrated area. This study investigates the effect of various types of urban green infrastructure on mitigating disaster damage in Korea. Tobit model is used to analyze the factors that determine disaster damage. Damage variation is predicted with scenarios of RCP 8.5 and urban green spaces. Seventy-four districts and counties in seven metropolitan areas are defined as the unit and the period from 2005 to 2013 is considered in the analysis. The results indicate that higher urban green ratio, sewer length, financial independence rate, and local government’s budget are relating to lower disaster damage. Based on a precipitation level of RCP 8.5 scenario in 2050, an increase in economic damage is expected to range from 262 to 1086%. However, with an increase in urban green ratio by 10%, increased economic damage is only expected to range from 217 to 1013%. The results suggest that green spaces play important role to mitigate precipitation related disasters. Highly concentrated urban areas need to consider various types of urban green infrastructure to prepare for an increase in precipitation due to climate change.
Sustainability Experiments in the Agri-Food System: Uncovering the Factors of New Governance and Collaboration Success
Authors: Hubeau Marianne , Marchand Fleur , Van Huylenbroeck Guido
Published: June 2017

In recent years, research, society and industry recognize the need to transform the agri-food system towards sustainability. Within this process, sustainability experiments play a crucial role in transforming the structure, culture and practices. In literature, much attention is given to new business models, even if the transformation of conventional firms toward sustainability may offer opportunities to accelerate the transformation. Further acceleration could be achieved through collaboration of multiple actors across the agri-food system, but this calls for a systems approach. Therefore, we developed and applied a new sustainability experiment systems approach (SESA) consisting of an analytical framework that allows a reflective evaluation and cross-case analysis of multi-actor governance networks based on business and learning evaluation criteria. We performed a cross-case analysis of four agri-food sustainability experiments in Flanders to test and validate SESA. Hereby, the key factors of the success of collaboration and its performance were identified at the beginning of a sustainability experiment. Some of the key factors identified were risk sharing and the drivers to participate. We are convinced that these results may be used as an analytical tool for researchers, a tool to support and design new initiatives for policymakers, and a reflective tool for participating actors.
Impact of Land Use Intensity on Ecosystem Services: An Example from the Agro-Pastoral Ecotone of Central Inner Mongolia
Authors: Li Qian , Zhang Xuefeng , Liu Qingfu , Liu Yang , Ding Yong , Zhang Qing
Published: June 2017

Land use intensity is an important indicator of human activities, so we quantified the land use intensity and five ecosystem services (soil conservation, water conservation, carbon storage, net primary productivity (NPP), and crop production) in 13 subbasins of the Tabu River Basin in an agro-pastoral ecotone in central Inner Mongolia. Furthermore, we analyzed the relationships among ecosystem services and the responses of the services to the impact of land use intensity. The primary conclusions were as follows: (1) All five ecosystem services gradually diminished from the upper to the lower reaches of the Tabu River Basin; (2) Water conservation exhibited a trade-off relationship with soil conservation, NPP, and crop production, but it exhibited a synergistic relationship with carbon storage. There were also synergistic relationships between soil conservation, carbon storage, NPP, and crop production; (3) As land use intensity increased, soil conservation, NPP and crop production monotonically increased. In contrast, water conservation exhibited a monotonically decreasing trend, and carbon storage followed a unimodal curve; (4) In this region, suitable ecosystem services were sustained at a land use intensity of approximately 3.95.
Identification of Sustainability Key Factors Based on Capturing Dominant Feedbacks of Behavioural Stereotypes in Socio-Economic Systems
Authors: Bureš Vladimír , Rácz Fridrich
Published: June 2017

Sustainability represents a system attribute that is widely investigated in many disciplines. System dynamics is mostly used for modelling specific issues. Not only can this methodology be used for this purpose, it can also be applied for the identification of behavioural stereotypes and consequent designation of variables that shape sustainability of the system. Based on the set of interviews with a sample of socio-economic system representatives, stereotypes are captured and modelled with the help of causal loop diagrams. After several modelling iterations that synchronised the acquired models with the obtained responses, four main key stereotypes were identified-quality, ego, competence, and motivation. Both dominant feedback loops and important multi-input and multi-output variables are used for their description. Thus, the models provide an endogenous explanation of their importance for sustainability and help to identify its key factors.
Characterization of Hemagglutinin Negative Botulinum Progenitor Toxins
Authors: Kalb Suzanne , Baudys Jakub , Smith Theresa , Smith Leonard , Barr John
Published: June 2017

Botulism is a disease involving intoxication with botulinum neurotoxins (BoNTs), toxic proteins produced by Clostridium botulinum and other clostridia. The 150 kDa neurotoxin is produced in conjunction with other proteins to form the botulinum progenitor toxin complex (PTC), alternating in size from 300 kDa to 500 kDa. These progenitor complexes can be classified into hemagglutinin positive or hemagglutinin negative, depending on the ability of some of the neurotoxin-associated proteins (NAPs) to cause hemagglutination. The hemagglutinin positive progenitor toxin complex consists of BoNT, nontoxic non-hemagglutinin (NTNH), and three hemagglutinin proteins; HA-70, HA-33, and HA-17. Hemagglutinin negative progenitor toxin complexes contain BoNT and NTNH as the minimally functional PTC (M-PTC), but not the three hemagglutinin proteins. Interestingly, the genome of hemagglutinin negative progenitor toxin complexes comprises open reading frames (orfs) which encode for three proteins, but the existence of these proteins has not yet been extensively demonstrated. In this work, we demonstrate that these three proteins exist and form part of the PTC for hemagglutinin negative complexes. Several hemagglutinin negative strains producing BoNT/A, /E, and /F were found to contain the three open reading frame proteins. Additionally, several BoNT/A-containing bivalent strains were examined, and NAPs from both genes, including the open reading frame proteins, were associated with BoNT/A. The open reading frame encoded proteins are more easily removed from the botulinum complex than the hemagglutinin proteins, but are present in several BoNT/A and /F toxin preparations. These are not easily removed from the BoNT/E complex, however, and are present even in commercially-available purified BoNT/E complex.
Influence of Anionic Surfactant on Saturated Hydraulic Conductivity of Loamy Sand and Sandy Loam Soils
Authors: Peng Zhenyang , Darnault Christophe , Tian Fuqiang , Baveye Philippe , Hu Hongchang
Published: June 2017

Surfactants released into the terrestrial environment in large amounts can potentially alter the physical, chemical and biological properties of soils, particularly the saturated hydraulic conductivity (Ks). Unfortunately findings regarding this process are quite limited. In this study, column tests were used to analyze the effects of Aerosol 22, a widely used anionic surfactant, on Ks of loamy sand and sandy loam soils. Solutions were injected into columns from the bottom with controlled pressure heads. Both the overall Ks of columns and the Ks of 6 layers at distances of 0–1 cm, 1–3 cm, 3–5 cm, 5–7 cm, 7–9 cm, and 9–10 cm from the bottom, were continuously monitored before and after the surfactant injections. Results showed that the overall Ks of all columns decreased after 2–4 pore volumes of the surfactant injections. However, stabilization and even increase at the beginning of the surfactant injection was also observed due to the different Ks variations in different layers. Specifically, a surfactant injection of 2–4 pore volumes continuously decreased the Ks of the 0–1 cm layers which yielded a Ks reduction of two orders of magnitude and dominated the Ks variations of the column. In contrast, an increase in the Ks of the 1–3 cm and 3–5 cm layers was more likely, while Ks variation of the 5–10 cm layers was less likely. We hypothetically attributed the Ks variations to the swelling of clay, the collapse of soil aggregates and subsequent particle displacements from surfactant adsorption, which caused pore clogging in the bottom 0–1 cm layer and higher porosities in the layers above. The adsorption of the surfactant aggregates and crystallization were also possibly thought to cause a pore clogging in the bottom layer thus decrease the surfactant concentration from the inlet, the severity of which affects these layers less at greater distances from the inlet. In view of the uncertainty showed by the experimental results, we also suggest to include more replicate columns in future studies, so as to increase the repeatability of the measurements.
Fermi Gamma-Ray Pulsars: Understanding the High-energy Emission from Dissipative Magnetospheres
Authors: Kalapotharakos Constantinos , Harding Alice K. , Kazanas Demosthenes , Brambilla Gabriele
Published: June 2017

Based on the Fermi observational data, we reveal meaningful constraints for the dependence of the macroscopic conductivity (σ) of dissipative pulsar magnetosphere models on the corresponding spin-down rate,

. Our models are refinements of the FIDO (Force-free Inside, Dissipative Outside) models, which have dissipative regions that are restricted on the equatorial current sheet outside of the the light-cylinder. Taking into account the observed cutoff energies of all of the Fermi pulsars and assuming that (a) the corresponding γ-ray pulsed emission is due to curvature radiation at the radiation-reaction-limit regime, and (b) this emission is produced at the equatorial current sheet near the light cylinder, we show that the Fermi data provide clear indications about the corresponding accelerating electric-field components. A direct comparison between the Fermi cutoff energies and the model ones reveals that σ increases with

for high

-values, while it saturates for low ones. This comparison indicates also that the corresponding gap width increases toward low

-values. Assuming the Goldreich–Julian flux for the emitting particles, we calculate the total γ-ray luminosity (L

γ
). A comparison between the dependence of the Fermi L

γ
-values and the model ones on

indicates an increase of the emitting particle multiplicity with

. Our modeling, guided by the Fermi data alone, enhances our understanding of the physical mechanisms behind the high-energy emission in pulsar magnetospheres.
Critical Outcomes in Longitudinal Observational Studies and Registries in Patients with Rheumatoid Arthritis: An OMERACT Special Interest Group Report
Authors: Zamora Natalia V. , Christensen Robin , Goel Niti , Klokker Louise , Lopez-Olivo Maria A. , Kristensen Lars E. , Carmona Loreto , Strand Vibeke , Curtis Jeffrey R. , Suarez-Almazor Maria E.
Published: June 2017

Objective.

Outcomes important to patients are those that are relevant to their well-being, including quality of life, morbid endpoints, and death. These outcomes often occur over the longterm and can be identified in prospective longitudinal observational studies (PLOS). There are no standards for which outcome domains should be considered. Our overarching goal is to identify critical longterm outcome domains for patients with rheumatic diseases, and to develop a conceptual framework to measure and classify them within the scope of OMERACT Filter 2.0.

Methods.

The steps of this initiative primarily concern rheumatoid arthritis (RA) and include (1) performing a systematic review of RA patient registries and cohorts to identify previously collected and reported outcome domains and measurement instruments; (2) developing a conceptual framework and taxonomy for identification and classification of outcome domains; (3) conducting focus groups to identify domains considered critical by patients with RA; and (4) surveying patients, providers, and researchers to identify critical outcomes that can be evaluated through the OMERACT filter.

Results.

In our initial evaluation of databases and registries across countries, we found both commonalities and differences, with no clear standardization. At the initial group meeting, participants agreed that additional work is needed to identify which critical outcomes should be collected in PLOS, and suggested several: death, independence, and participation, among others. An operational strategy for the next 2 years was proposed.

Conclusion.

Participants endorsed the need for an initiative to identify and evaluate critical outcome domains and measurement instruments for data collection in PLOS.
Hospitalizations in Patients with Systemic Lupus Erythematosus in an Academic Health Science Center
Authors: Gu Kaien , Gladman Dafna D. , Su Jiandong , Urowitz Murray B.
Published: June 2017

Objective.

Hospitalization occurs in about 10% of patients with systemic lupus erythematosus (SLE) each year and accounts for most of the direct cost of SLE patient care. We aimed to determine the frequency of admissions of patients with SLE and describe their causes and outcomes.

Methods.

We identified all hospitalizations at University Health Network in the periods 2011–2012 and 2013–2015 with an International Classification of Diseases, 10th ed. code of M32 (SLE). A retrospective chart review of these patients categorized them based on SLE care provider and cause of admission. Frequency of emergency room visits and duration of hospitalization were ascertained. Poisson and linear regressions were performed to determine factors associated with frequency and duration of hospitalizations.

Results.

There were 247 unique patients with SLE who were hospitalized a total of 491 times: 87.4% were women, average age of 43.9 ± 17.9 years, and disease duration 13.7 ± 12.3 years. Incidental causes were most common (35.6%); 21.4% and 22.4% of admissions were because of active SLE and infection, respectively. The patients with SLE averaged 1.6 hospitalizations lasting 8.5 days. Thirteen percent of hospitalizations resulted in intensive care unit admission, and 2.8% of hospitalizations resulted in death. Patient employment was associated with fewer hospitalizations during 2011–2015. Antimalarial use was associated with fewer hospitalizations as well as shorter length of stay during 2011–2012. The presence of damage correlated with increased hospitalizations. Higher educational level and antimalarial use correlated with shorter length of stay.

Conclusion.

Patients with SLE are frequently hospitalized, often because of active SLE or infection, and re-hospitalized within a short period of time.