bluuebunny/crossref_metadata_2025 huggingface dataset:
2′,5′-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis
Authors: Gerein V. , Rastorguev E. , Gerein J. , Lodemann E. , Pfister H. , Draf W. , Desloovere C.
Published: November 2004

Objective: Determination of early prognostic factors in patients with recurrent respiratory papillomatosis is extremely important, so the major goal of our prospective, multicentre study was to evaluate (1) the feasibility of various factors to determine prognosis of the clinical course,as well as (2) the response to interferon-alpha therapy in recurrent respiratory papillomatosis.

Methods: Forty-two patients with recurrent respiratory papillomatosis were treated with interferon-alpha (3 MU/m2 three times per week; mean therapy duration was 2.7 ± 1.8 years)in 1983–1994 and followed-up until 2003. Human papilloma virus (HPV) type, recurrent respiratory papillomatosis severity and 2′,5′-oligoadenylate synthetase activity were determined by standard methods and analysed for correlation with the results of long-term clinical outcome.

Results and conclusion: Patients with HPV type 11, a severity score >4, a high number of surgical procedures prior to interferon-alpha therapy and a high basal 2′,5′-oligoadenylate synthetase activity should be considered at high risk of an aggressive clinical course, often with spread to lower airway passages, malignant transformation and death. Human papilloma virus type, score for recurrent respiratory papillomatosis severity, number of surgical procedures and 2′,5′-oligoadenylate synthetase activity showed significant association with response to interferon-alpha therapy and the long-term clinical course, so these factors have value in predicting prognosis in recurrent respiratory papillomatosis.
The myth of tracheomalacia and difficult intubation in cases of retrosternal goitre
Authors: Bennett A.M.D. , Hashmi S.M. , Premachandra D.J. , Wright M.M.
Published: November 2004

Although it is widely believed that management of the airway is difficult in surgery for retrosternal goitre, a review of the literature, revealing management of 1969 patients with retrosternal goitre, provided scant evidence of difficult intubation or post-operative tracheomalacia resulting in tracheal collapse. This was reflected in our own series of 18 thyroidectomies for retrosternal goitre performed at our hospitals.
Does occurrence of keratinizing stratified squamous epithelium in the middle-ear cavity always indicate a cholesteatoma?
Authors: Stenfors Lars-Eric
Published: November 2004

The origin and behaviour of keratinizing stratified squamous epithelium, anessential component of cholesteatoma occurring in the middle-ear cavity, has puzzled otologistsfor decades. In this experimental study in 16 cats, central (n = 23) and peripheral (n = 9) tympanic membrane perforations were observed for up to 63 days before sacrifice. The tympanic membranes with bony rim were excised, decalcified and embedded in Epon 812. Sections werestained with toluidine blue and examined using a light microscope. The perforation had been sealed by meatal epithelium exhibiting pronounced hyperplasia and keratin formation, lying on abedof granulation tissue. Subtotal central perforations healed within 14 days, forming a bowl-shaped tympanic membrane and leaving parts of the handle of the malleus (with meatal epithelium) protruding freely into the middle-ear cavity. Stratified squamous epithelium, morphologicallyidentical with that of external ear canal epidermis, could be observed on the malleus even 63 days after operation. This meatal epithelium was non-keratinizing, non-invasive, and showed no destructive properties typical of acquired cholesteatoma. During certain circumstances, the cellcycle of hyperplastic epidermal epithelium within the middle-ear cavity can evidently be arrested and inactivated by a local defence mechanism.
Concha bullosa: reducing middle meatal adhesions by preserving the lateral mucosa as a posterior pedicle flap
Authors: Sigston Elizabeth A.W. , Iseli Claire E. , Iseli Tim A.
Published: November 2004

Background: Concha bullosa, an extensively pneumatized middle turbinate, may obstruct the paranasal sinuses. Messerklinger’s partial lateral turbinectomy is commonly used to debulk the concha bullosa, leaving a raw surface with the potential for adhesions.

Materials and methods: A modified technique of partial lateral turbinectomy is described. A posterior pedicled mucosal flap covers the inferior raw surface of the medial lamella of the middle turbinate. Three-month follow up of a consecutive series is compared with concurrent controls.

Results: Two (7 per cent) of 28 posterior pedicled flap and four (21 per cent) of 19 traditional partial lateral turbinectomies developed mild middle meatal adhesions (p = 0.011). Posterior pedicled flap reduced the need for post-operative cleaning of the middle meatus.

Conclusion: The posterior pedicled mucosal flap is a simple modification to partial lateral turbinectomy that covers the raw surface facing the lateral nasal wall, significantly reducing adhesions and speeding recovery.
1H NMR Analysis of GHB and GBL: Further Findings on the Interconversion and a Preliminary Report on the Analysis of GHB in Serum and Urine
Authors: Del Signore AG , McGregor M , Cho BP
Published: November 2004

A 1H nuclear magnetic resonance (1H NMR) method for the determination of gamma-hydroxybutyric acid (GHB) and gamma-hydroxybutyrolactone (GBL) in human serum and urine using spiked samples has been developed. The method gives linear responses (correlation coefficients of 0.99 or greater) over the concentration range 0.01 mg/mL to 4.0 mg/mL in urine and 0.3 mg/mL to 2.0 mg/mL in serum. No sample pretreatment is required. Studies of the chemical interconversion of GBL and GHB showed hydrolysis of GBL to be rapid at pH 11.54, slower and less complete (30% hydrolysis) at pH 2.54 and slowest at pH 7.0, reaching 30% hydrolysis in about 40 days. No esterification of GHB was observed at any pH.
Neck Injuries Caused by Automatic Two-point Seat Belts: An Analysis of Four Cases
Authors: Spitz DJ , Prator PC , Stratton JE , Labiste L , Augenstein JS , Mackinnon J , Phillips J , Singer M , Perdeck E , Chimento S
Published: November 2004

Although seat belts significantly reduce the extent and severity of injuries sustained by motor vehicle occupants, seat belts are known to be associated with chest and abdominal trauma. Less commonly understood are severe neck injuries caused by the use of two-point automatic shoulder harnesses without concurrent use of a manual lap belt. Such injuries may include cervical spine fractures, craniocervical dislocations and rarely decapitation. Recognizing patterned injuries caused by seat belts and the ability to correlate autopsy findings with the circumstances surrounding the death will allow for correct interpretation of seat-belt related trauma. The four cases described detail fatal neck injuries as a result of improper seat belt use in which an automatic two-point shoulder harness was used without a manual lap restraint. In two of the cases, the victims were decapitated.
The Scope of Anthropological Contributions to Human Rights Investigations
Authors: Steadman DW , Haglund WD
Published: November 2004

This paper examines the participation of anthropologists in international human rights investigations between 1990 and 1999 by surveying four of the most active organizations, including the Argentine Forensic Anthropology Team, the Guatemalan Forensic Anthropology Foundation, Physicians for Human Rights and the U.N.-sponsored International Criminal Tribunal for the former Yugoslavia. The education level, sex, nationality and primary role of the anthropological members of each team are quantified, as are the types of projects in which they contributed. The results show that 134 anthropologists from 22 nations investigated nearly 1300 sites in 33 countries during the study period. While involvement is not limited to those with advanced degrees and few obstacles are placed before anthropologists who wish to participate, full-time service within these organizations is rare and those interested in a career in forensic anthropology and human rights should understand the employment limitations.
Allele Frequencies for Fifteen STR Loci in Guinea-Bissau Population
Authors: Pereira JV , Serra A , Anjos MJ , Vide MC , Corte-Real F , Vieira DN
Published: November 2004

Guinea-Bissau population, ethnical groups: Balanta, Beafada, Cassanga, Fula, Mancanha, Mandinga, Manjaco, Nalú Papel, n=92
Review of: Analysis and Interpretation of Fire Scene Evidence
Authors: Lentini JJ
Published: November 2004

Analysis and Interpretation of Fire Scene Evidence bills itself as “essentiall for forensic scientists, insurance investigators, fire departments, and other specialists involved in the investigation of fire scenes. It also benefits attorneys and judges involved in arson cases.” That may be true of some parts of this book, but it is definitely a mixed bag. When assembling a cast of distinguished authors to put together a volume like this, a light touch by the editors is frequently all that is required, but in this case, the editors' touch seems to be entirely weightless. The title is misleading, as there is very little actual guidance of “interpretation” in the book.
Review of: Fire Investigation
Authors: DeHaan JD
Published: November 2004

The newest addition to the fire investigation bookshelf comes from a very different perspective, at least for American readers. Edited by Niamh Nic Daéid, Senior Lecturer in the Forensic Science Unit at the University of Strathclyde in Glasgow (who herself has considerable expertise in various aspects of fire investigation), the book draws upon first-class subject experts to write about what they know best. In British practice, the laboratory-based forensic scientist is often directly involved in many more aspects of fire investigations than in the U.S. From scene investigation and cause and origin determination to the identification of materials and ignition processes, and testing of materials in both accidental and intentionally set fires, the forensic lab is called upon by public- and private sector investigators. In the U.S. the forensic lab analyst is most often charged only with fire debris analysis, with fire and police investigators doing nearly everything else.
Stimulation of Kaposi's sarcoma‐associated herpesvirus viremia during hematopoietic stem cell mobilization with filgrastim
Authors: Neid James M. , Schooley Robert T. , Campbell Thomas B.
Published: November 2004

The effects of hematopoietic stem cell (HSC) mobilization on Kaposi's sarcoma‐associated herpesvirus (KSHV) were evaluated in three KSHV and human immunodeficiency virus type 1 co‐infected subjects. KSHV DNA was not detected in purified CD34+ cell preparations from the period of filgrastim treatment. However, two of 3 subjects had transiently increased cell‐free plasma KSHV DNA during filgrastim treatment. Peak plasma KSHV DNA (2,600 and 4,300 copies/mL) occurred on day 4 and declined to below the limit of detection by day 7. These findings suggest that, although CD34+ cell preparations do not have evidence of KSHV infection, HSC mobilization may stimulate KSHV replication in other cellular compartments that contribute to KSHV viremia. Am. J. Hematol. 77:410–412, 2004. © 2004 Wiley‐Liss, Inc.
Response of factor V inhibitor to rituximab in a patient who received liver transplantation for primary biliary cirrhosis
Authors: Lian Eric Chun‐Yet , Tzakis Andreas G. , Andrews David
Published: November 2004

A 43‐year‐old patient developed factor V inhibitor 6 months after liver transplantation for primary biliary cirrhosis in association with Sjögren's syndrome/systemic lupus erythematosus. She suffered from ecchymoses in the lower extremities. The factor V inhibitor was eradicated after 10 weekly doses of 375–500 mg/m2 rituximab. Am. J. Hematol. 77:363–365, 2004. © 2004 Wiley‐Liss, Inc.
Efficacy of imatinib mesylate (STI571) in chronic neutrophilic leukemia with t(15;19): Case report
Authors: Choi In Keun , Kim Byung‐Soo , Lee Kyung‐A , Ryu Sookwon , Seo Hee Yun , Sul Hyeryoung , Choi Jong Gwon , Sung Hwa Jung , Park Kyong Hwa , Yoon So Young , Oh Sang Cheul , Seo Jae Hong , Choi Chul Won , Shin Sang Won , Yoon Soo‐Young , Cho Yunjung , Kim Young‐Kee , Kim Yeul Hong , Kim Jun Suk
Published: November 2004

Chronic neutrophilic leukemia (CNL) is a rare hematologic disorder, for which there is no standard therapy. Recently, STI (imatinib mesylate) has been shown to be effective in treating patients with chronic myeloproliferative disorder (CMPD) displaying the translocation of the PDGFβR gene. Here, we present a case of a patient with CNL carrying t(15;19)(q13;p13.3) who achieved a cytogenetic remission following treatment with imatinib, 400 mg daily. After failure of alpha interferon and hydroxyurea therapy, a durable and complete clinical and cytogenic remission was induced by imatinib. To our knowledge, this is the first case with CNL who showed complete response with cytogenic remission after treatment of imatinib. The mechanism of response to this molecule is unknown in our case (other oncogenes than c‐kit, tyrosine kinase, or PDGFR may be involved). The patient remains in complete remission with an excellent performance status after 7 months of therapy. We demonstrate here that imatinib can induce a clinical and cytogenetic response in a case of CNL associated with a novel translocation other than a 5q33 rearrangement. Further studies including the molecular cloning of the t(15;19)(q13;p13.3) will be important in understanding the pathophysiology of CNL with a heterogeneous clinical course and the exploitation of the basic mechanisms of imatinib treatment. Am. J. Hematol. 77:366–369, 2004. © 2004 Wiley‐Liss, Inc.
Initial increase in the cryoglobulin level after rituximab therapy for type II cryoglobulinemia secondary to Waldenström macroglobulinemia does not indicate failure of response
Authors: Ghobrial Irene M. , Uslan Daniel Z. , Call Timothy G. , Witzig Thomas E. , Gertz Morie A.
Published: November 2004

Type II (mixed) cryoglobulinemia is a systemic vasculitis that may affect many organs, including the skin, leading to ulcerations secondary to immune complex deposition. We report a patient who presented with a large necrotic ulcerative lesion on the right ankle secondary to type II cryoglobulinemic vasculitis due to Waldenström macroglobulinemia that was resistant to multiple modalities of therapy. Amputation to prevent further necrosis and infections was almost performed. Treatment with rituximab was initiated and the patient had a dramatic response. This case report highlights the effectiveness and prompt response to rituximab when used in patients with small vessel vasculitis and skin ulceration. We describe a rise in the cryoglobulin level that may occur initially after rituximab therapy. Am. J. Hematol. 77:329–330, 2004. © 2004 Wiley‐Liss, Inc.
Hemoglobin Titusville, a low oxygen affinity variant hemoglobin, in a family of Northern European background
Authors: Luo Hong‐yuan , Irving Ian , Prior John , Lim Erna , Eung Shawn H. , Skelton Timothy P. , Erber Wendy N. , Steinberg Martin H. , Chui David H.K.
Published: November 2004

We report the second case of Hb Titusville in a family of Northern European background. This variant hemoglobin caused by an α‐globin gene mutation has decreased oxygen affinity. Correct diagnosis is clinically important to spare affected individuals extensive investigations into other causes of low oxygen saturation in peripheral blood. Am. J. Hematol. 77:384–386, 2004. © 2004 Wiley‐Liss, Inc.
CD5‐negative chronic lymphocytic leukemia with indolent clinical course and autoimmune thrombocytopenia, successfully treated with rituximab
Authors: Okamoto Masashi , Nakano Sonoko , Namura Kyoko , Yamada Noriko , Uchida Ryo , Fuchida Shin‐ichi , Okano Akira , Ochiai Naoya , Shimazaki Chihiro
Published: November 2004

A 59‐year‐old male with lymphocytosis and thrombocytopenia was asymptomatic without lymphadenopathy or hepatosplenomegaly over 10 years. He was admitted to our hospital because his thrombocytopenia had worsened. The clonal lymphocytes appeared as regular small mature lymphocytes on blood films, and bone marrow biopsy showed diffuse infiltration of mature lymphocytes. However, megakaryocytes also presented. The immunophenotypic analysis by flow cytometry revealed that the lymphocytes were positive for CD19, CD20, CD22, and surface membrane immunoglobulin (SmIg) M and D‐lambda and were negative for CD5, CD10, CD11c, CD23, and other lineage markers. Expression levels of CD20 and SmIg were strong. The markers were consistent with CD5− CLL with autoimmune thrombocytopenia. He received rituximab, and a rapid decrease of lymphocytes with concomitant increase of platelets was observed. A few cases of CD5− CLL with a stable clinical course have been reported, thought to be B lymphocytosis of undetermined significance (MLUS). This is the first report of CD5− CLL with indolent clinical course associated with autoimmune thrombocytopenia, successfully treated with rituximab. Am. J. Hematol. 77:413–415, 2004. © 2004 Wiley‐Liss, Inc.
Pericardial effusion: A rare presentation of adult T‐cell leukemia/lymphoma
Authors: Chaves Fernando P. , Quillen Karen , Xu Dongsheng
Published: November 2004

Adult T‐cell leukemia/lymphoma (ATLL) has a wide variety of clinical presentations. The most common ones include leukemia, hypercalcemia, lymphadenopathy, hepatosplenomegaly, and skin lesions. We report a case of ATLL in a 73‐year‐old woman who presented initially with chest discomfort and shortness of breath. The patient had no peripheral lymphadenopathy, circulating lymphoma cells, hepatosplenomegaly, or skin lesions. CT scan showed small mediastinal lymph nodes and pericardial effusion. Diagnosis was established by cytomorphologic evaluation and flow cytometric analysis of the pericardial fluid. Cardiac involvement is a rare event in ATLL and, when present, usually is a late finding in the setting of disseminated disease. This case was unusual because the patient lacked all common clinical features of ATLL. We present this case so as to increase awareness that ATLL could initially present with pericardial effusion. The pathophysiologic mechanisms of cardiac involvement are also discussed. Am. J. Hematol. 77:381–383, 2004. © 2004 Wiley‐Liss, Inc.
Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men
Authors: Luderer Ulrike , Bushley Abigail , Stover Bert D. , Bremner William J. , Faustman Elaine M. , Takaro Timothy K. , Checkoway Harvey , Brodkin Carl Andrew
Published: November 2004

Background

Little is known about the effects of organic solvents on male reproductive health. To assess fertility and reproductive endocrine function in solvent‐exposed men, we investigated time‐to‐pregnancy using a retrospective cohort design and cross‐sectionally measured reproductive hormone concentrations in painters and millwrights compared to a reference group of carpenters.

Methods

Detailed occupational, exposure, medical, and time‐to‐pregnancy histories were obtained by telephone interview. Plasma luteinizing hormone (LH), follicle‐stimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Exposure indices, which summarized working life exposure to total solvents, chlorinated solvents, aromatic solvents, and thinners, degreasers, varnishes, and adhesives as a category were calculated from exposure histories.

Results

FSH concentrations increased significantly with increasing exposure indices for all solvents and for chlorinated solvents. There were no significant associations of solvent exposure indices with LH or testosterone levels. LH, FSH, and testosterone concentrations also did not differ by job title. Using Cox regression, time‐to‐pregnancy was non‐significantly longer in the painters and millwrights than the carpenters. There was no significant association between time‐to‐pregnancy and any of the solvent exposure indices; however, it should be noted that some of the pregnancies occurred more than 20 years previously, potentially reducing the reliability of the retrospectively collected pregnancy and exposure data.

Conclusions

The significant associations between FSH levels and solvent exposure indices suggest the potential for adverse effects of solvent exposures on reproductive function in men. Am. J. Ind. Med. 46:614–626, 2004. © 2004 Wiley‐Liss, Inc.
Finally, a sense of closure? Animal models of human ventral body wall defects
Authors: Brewer Stephanie , Williams Trevor
Published: November 2004

Malformations concerning the ventral body wall constitute one of the leading categories of human birth defects and are present in about one out of every 2000 live births. Although the occurrence of these defects is relatively common, few detailed experimental studies exist on the development and closure of the ventral body wall in mouse and human. This field is further complicated by the array of theories on the pathogenesis of body wall defects and the likelihood that there is no single cause for these abnormalities. In this review, we summarize what is known concerning the mechanisms of normal ventral body wall closure in humans and mice. We then outline the theories that have been proposed concerning human body wall closure abnormalities and examine the growing number of mouse mutations that impact normal ventral body wall closure. Finally, we speculate how studies in animal models such as mouse andDrosophilaare beginning to provide a much‐needed mechanistic framework with which to identify and characterize the genes and tissues required for this vital aspect of human embryogenesis. BioEssays 26:1307–1321, 2004. © 2004 Wiley Periodicals, Inc.
Porphyrin Derivatives for Telomere Binding and Telomerase Inhibition
Authors: Dixon Isabelle M. , Lopez Frédéric , Estève Jean‐Pierre , Tejera Agueda M. , Blasco María A. , Pratviel Geneviève , Meunier Bernard
Published: November 2004

The capacity of G‐quadruplex ligands to stabilize four‐stranded DNA makes them able to inhibit telomerase, which is involved in tumour cell proliferation. A series of cationic metalloporphyrin derivatives was prepared by making variations on a meso‐tetrakis(4‐N‐methyl‐pyridiniumyl)porphyrin skeleton (TMPyP). The DNA binding properties of nickel(II) and manganese(III) porphyrins were studied by surface plasmon resonance, and the capacity of the nickel porphyrins to inhibit telomerase was tested in a TRAP assay. The nature of the metal influences the kinetics (the process is faster for Ni than for Mn) and the mode of interaction (stacking or external binding). The chemical alterations did not lead to increased telomerase inhibition. The best selectivity for G‐quadruplex DNA was observed for Mn‐TMPyP, which has a tenfold preference for quadruplex over duplex.
Water‐Soluble Molecular Capsules: Self‐Assembly and Binding Properties
Authors: Corbellini Francesca , Knegtel Ronald M. A. , Grootenhuis Peter D. J. , Crego‐Calama Mercedes , Reinhoudt David N.
Published: November 2004

The self‐assembly and characterization of water‐soluble calix[4]arene‐based molecular capsules (1⋅2) is reported. The assemblies are the result of ionic interactions between negatively charged calix[4]arenes 1 a and 1 b, functionalized at the upper rim with amino acid moieties, and a positively charged tetraamidiniumcalix[4]arene 2. The formation of the molecular capsules is studied by 1H NMR spectroscopy, ESI mass spectrometry (ESI‐MS), and isothermal titration calorimetry (ITC). A molecular docking protocol was used to identify potential guest molecules for the self‐assembled capsule 1 a⋅2. Experimental guest encapsulation studies indicate that capsule 1 a⋅2 is an effective host for both charged (N‐methylquinuclidinium cation) and neutral molecules (6‐amino‐2‐methylquinoline) in water.
A Comparison of Structure and Stability Between the Group 11 Halide Tetramers M4X4 (M: Cu, Ag, or Au; X: F, Cl, Br, or I) and the Group 11 Chloride and Bromide Phosphanes (XMPH3)4
Authors: Schwerdtfeger Peter , Krawczyk Robert P. , Hammerl Anton , Brown Reuben
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Crystal Growth of the CdGa2(1‐x)Cr2xSe4 Compounds by Chemical Transport Method.
Authors: Sagredo V. , de Chalbaud L. M.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Metal—Metal Bonding in ScTaN2. A New Compound in the System ScN—TaN.
Authors: Niewa R. , Zherebtsov D. A. , Schnelle W. , Wagner F. R.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Three New Organically Templated Polyoxomolybdates with Capping Selenite Anions.
Authors: Feng Mei‐Ling , Mao Jiang‐Gao
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Micrometric Single Crystal Germanates Obtained Using a Double‐Spherical Mirror Furnace.
Authors: Juarez‐Arellano E. A. , Rosales I. , Gamboa‐Espinosa G. V. , Lara J. A. , Bucio L. , Orozco E.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
N‐α‐Benzyloxyacetyl Derivatives of (S)‐4‐Benzyl‐5,5‐dimethyloxazolidin‐2‐one for the Asymmetric Synthesis of Differentially Protected α,β‐Dihydroxyaldehydes.
Authors: Davies Stephen G. , Hunter Ian A. , Nicholson Rebecca L. , Roberts Paul M. , Savory Edward D. , Smith Andrew D.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Studies on Catalytic Asymmetric Nozaki—Hiyama Propargylation.
Authors: Inoue Masahiro , Nakada Masahisa
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Highly Enantioselective Conjugate Addition of Malonate and β‐Ketoester to Nitroalkenes: Asymmetric C—C Bond Formation with New Bifunctional Organic Catalysts Based on Cinchona Alkaloids.
Authors: Li Hongming , Wang Yi , Tang Liang , Deng Li
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Studies on Novel Synthetic Methodologies. Part 43. Chemoselective Deprotection of Trityl Ethers Using Silica‐Supported Sodium Hydrogen Sulfate.
Authors: Das Biswanath , Mahender Gurram , Kumar Vooturi Sunil , Chowdhury Nikhil
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Polymer‐Supported Copper Complex for C—N and C—O Cross‐Coupling Reactions with Aryl Boronic Acids.
Authors: Chiang Gary C. H. , Olsson Thomas
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Arylation of Diversely Substituted Hydrazines by Tri‐ and Pentavalent Organobismuth Reagents.
Authors: Tsubrik Olga , Maeorg Uno , Sillard Rannar , Ragnarsson Ulf
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Trimethylsilylcyanation of N‐[3‐(2‐Furyl)‐2‐propenylidene]trifluoromethylanilines.
Authors: Iovel I. , Golomba L. , Belyakov S. , Kemme A. , Popelis J. , Lukevics E.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Intramolecular C—H Insertions Adjacent to Sulfur for the Diastereoselective Synthesis of Thienofuranones.
Authors: Skerry Paul S. , Swain Nigel A. , Harrowven David C. , Smyth Donald , Bruton Gordon , Brown Richard C. D.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of 1‐Substituted 2‐Amino‐3‐cyanopyrroles: New Synthetic Precursors for 5,6‐Unsubstituted Pyrrolo[2,3‐d]pyrimidines.
Authors: Chien Tun‐Cheng , Meade Eric A. , Hinkley Jack M. , Townsend Leroy B.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Highly Chemoselective 2,4,5‐Triaryl‐1,3‐dioxolane Formation from Intermolecular 1,3‐Dipolar Addition of Carbonyl Ylide with Aryl Aldehydes.
Authors: Lu Chong‐Dao , Chen Zhi‐Yong , Liu Hui , Hu Wen‐Hao , Mi Ai‐Qiao
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Weinreb Nitrile Oxide and Nitrone for Cycloaddition.
Authors: Parhi Ajit K. , Franck Richard W.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Structure—Activity Relationships of 3,5‐Diarylisoxazoles and 3,5‐Diaryl‐1,2,4‐oxadiazoles, Novel Classes of Small Molecule Interleukin‐8 (IL‐8) Receptor Antagonists.
Authors: Weidner‐Wells Michele A. , Henninger Todd C. , Fraga‐Spano Stephanie A. , Boggs Christine M. , Matheis Michele , Ritchie David M. , Argentieri Dennis C. , Wachter Michael P. , Hlasta Dennis J.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Approaches to Synthesis of 4‐Alkyl‐6‐amino‐5‐cyano‐3‐methyl(propyl, phenyl)‐2H,4H‐pyrano[2,3‐c]pyrazoles.
Authors: Dyachenko V. D. , Rusanov E. B.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
An Improved Synthesis of Homoisoflavanones.
Authors: Jaspal Sharda , Grover S. K.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Some Biologically Active Pyrazole, Thiazolidinone, and Azetidinone Derivatives.
Authors: Pawar R. B. , Mulwad V. V.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
SnCl4‐Promoted Ethenylation Reaction of Hydroxylated Heteroarenes.
Authors: Akamatsu Kensuke , Amemiya Ryo , Yamaguchi Masahiko
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Inverse Electron‐Demand Aza‐[4 + 2] Cycloaddition Reactions of Allenamides.
Authors: Berry Craig R. , Hsung Richard P.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 1,2,3,4‐Tetrahydroisoquinolines and 2,3,4,5‐Tetrahydro‐1H‐2‐benzazepines Combining Sequential Palladium‐Catalyzed ortho Alkylation/Vinylation with Aza‐Michael Addition Reactions.
Authors: Ferraccioli Raffaella , Carenzi Davide , Catellani Marta
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Cytostatic Properties of Some 6H‐Indolo[2,3‐b][1,8]naphthyridine Derivatives.
Authors: Mastalarz Henryk , Jasztold‐Howorko Ryszard , Rulko Felicja , Croisy Alain , Carrez Daniele
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Approach to Geminally Alkylated Azaphthalans via a Consecutive Double Desilylation—Alkylation Reaction: Application to a Synthesis of Cerpegin.
Authors: Sarkar Tarun K. , Basak Sankar
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Xanthates Derived from 1,3‐Dithiane and Its Monosulfoxide; One‐Carbon Radical Equivalents.
Authors: de Greef Michiel , Zard Samir Z.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Preparation of New N6,9‐Disubstituted 2‐Phenyl‐adenines and Corresponding 8‐Azaadenines. A Feasibility Study for Application to Soid‐Phase Synthesis. Part 1.
Authors: Biagi Giuliana , Giorgi Irene , Livi Oreste , Pacchini Federica , Scartoni Valerio , Salerni Oreste LeRoy
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Intramolecular Nucleophilic Substitution of Hydrogen in (Quinoxalinyl‐2)aminovinyl Derivatives as a New Approach to Pyrrolo‐ and Indolo[2,3‐b]quinoxalines.
Authors: Kotovskaya S. K. , Charushin V. N. , Perova N. M. , Kodess M. I. , Chupakhin O. N.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Medium Ring Heterocycles Using an Intramolecular Heck Reaction.
Authors: Arnold Leggy A. , Luo Wenchen , Guy R. Kiplin
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of α,α‐Difluoro‐β‐amino Phosphonic Acids Using Sulfinimines.
Authors: Roeschenthaler Gerd‐Volker , Kukhar Valery , Barten Jan , Gvozdovska Natalia , Belik Michael , Sorochinsky Alexander
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Syntheses of 1,2,3,4,6,7,12,12b‐Octahydroindolo[2,3‐a]quinolizine and Harmicine Using a Chiral 1‐Allyl‐1,2,3,4‐tetrahydroxy‐β‐carboline as the Starting Material.
Authors: Itoh Takashi , Miyazaki Michiko , Nagata Kazuhiro , Nakamura Shigeru , Ohsawa Akio
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Facile Synthetic Route to (+)‐Allosedamine via Hydrolytic Kinetic Resolution and Olefin Metathesis.
Authors: Kang Byungman , Chang Sukbok
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiviral Activities of Novel 2′,4′‐ or 3′,4′‐Doubly Branched Carbocyclic Nucleosides as Potential Antiviral Agents.
Authors: Oh Chang Hyun , Hong Joon Hee
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Aziridinomitosenes Through Base‐Catalyzed Conjugate Addition.
Authors: Tsuboike Kazunari , Guerin David J. , Mennen Steven M. , Miller Scott J.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Studies Toward Diazonamide A: Initial Synthetic Forays Directed Toward the Originally Proposed Structure.
Authors: Nicolaou K. C. , Snyder Scott A. , Huang Xianhai , Simonsen Klaus B. , Koumbis Alexandros E. , Bigot Antony
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Transition State Inhibitors: A Basis for Rational Drug Design
Authors: Evans Gary B.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A New Principle in Combinatorial Asymmetric Transition Metal Catalysis: Mixtures of Chiral Monodentate P Ligands
Authors: Guo Hong‐Chao , Ding Kuiling , Dai Li‐Xin
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Eight‐Membered and Larger Rings
Authors: Newkome George R.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Five‐Membered Ring Systems with O and S (Se, Te) Atoms
Authors: Aitken R. Alan , Costello Stephen J.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Six‐Membered Ring Systems: Pyridines and Benzo Derivatives
Authors: Coffey D. Scott , Kolis Stanley P. , May Scott A.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
α,β‐Acetylenic Acids and Their Derivatives in Reactions with Hydrogen Sulfide and Thiols
Authors: Volkov A. N. , Volkova K. A.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
In situ Characterization of the Adsorption of Cinchona Chiral Modifiers on Platinum Surfaces
Authors: Ma Zhen , Lee Ilkeun , Kubota Jun , Zaera Francisco
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Strategies in Making Cross‐Linked Enzyme Crystals
Authors: Roy J. Jegan , Abraham T. Emilia
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Nuclear Quadrupole Resonance
Authors: Herreros Bruno , Harrison Gerard S.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterisation of the First Cyanodiselenoimidocarbonate [C2N2Se2]2− Complexes
Authors: Burchell Colin J. , Aucott Stephen M. , Slawin Alexandra M. Z. , Woollins J. Derek
Published: November 2004

[Pt(C2N2Se2)(PR3)2] (PR3 = PMe2Ph, PPh3) and [Pt(C2N2Se2)(PP)] (PP = dppe, dppm, dppf) were obtained by the reaction of the appropriate metal halide containing complex with potassium cyanodiselenoimidocarbonate. The dimeric cyanodiselenoimidocarbonate complexes [M{(C2N2Se2)(η5‐C5Me5)}2] (M = Rh Ir)] were synthesised from the appropriate transition metal dimer starting material. The cyanodiselenoimidocarbonate ligand is Se,Se‐bidentate in the monomeric complexes − the terminal CN group is approximately coplanar with the CSe2 group, and the nitrogen atom is trigonal therefore reducing the planar symmetry of the ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Octahedral Molybdenum Cluster Cyanide Complexes with Selenide and Halide Ligands in the Cluster Core
Authors: Mironov Yuri V. , Ikorskii Vladimir N. , Fedorov Vladimir E. , Ibers James A.
Published: November 2004

Two new octahedral molybdenum cluster cyanide complexes with mixed selenide/halide ligands in the cluster core, Cs5[Mo6Se3.6Cl4.4(CN)6] (1) and Cs5[Mo6Se3.4Br4.6(CN)6] (2), have been synthesized by the reaction of Mo6Cl12 or Mo6Br12 with an aqueous solution of Cs2Se3, and then with an aqueous solution of KCN. Both compounds have been characterized by single‐crystal X‐ray diffraction methods. The compounds are isostructural and crystallize in the trigonal space group P$\bar 3$
c1with two formula units per unit cell. The unit cell dimensions at 153 K are a = 9.8895(9) Å, c = 19.395(3) Å, V = 1642.7(3) Å3 (1) and a = 9.9805(9) Å, c = 19.763(2) Å, V = 1704.9(3) Å3 (2). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Antioxidant efficiency of oregano in frying and storage of fried products
Authors: Houhoula Dimitra P. , Oreopoulou Vassiliki , Tzia Constantina
Published: November 2004

The effect of oregano on the oxidative stability of cottonseed oil during frying of potato chips and on the storage stability of the products was studied. The ground spice or an ethanol‐derived extract was added to the oil before frying. The results showed that both additives decreased the rates of accumulation of conjugated dienes, polar compounds, polymerized triacylglycerols, dimeric triacylglycerols and the p‐anisidine value of the frying oil, while the hydrolytic compounds were not affected. The major decrease was observed in the accumulation of polymerized and dimeric triacylglycerols. The storage stability of the produced chips was estimated by the rate of increase of the peroxide value and of the conjugated dienes in the oil absorbed by them. Both rates were depressed when oregano was added to the frying oil, with the protective action of oregano extract being considerably greater than that of ground oregano. The protective action of oregano extracts obtained by successive extractions with petroleum ether (PE), diethyl ether (EE) and ethanol (EtOH) and added to the chips after frying was also examined. The results showed that the EE and EtOH extracts were very effective against oxidative deterioration.
Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer
Authors: Chang Young‐Woon , Jang Jae‐Young , Kim Nam‐Hoon , Lee Jae Won , Lee Hyo Jung , Jung Woon Won , Dong Seok‐Ho , Kim Hyo‐Jong , Kim Byung‐Ho , Lee Joung‐Il , Chang Rin
Published: November 2004

Interleukin‐1B and IL‐1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL‐1B‐511T polymorphism and the risk of GC in Asians. We tested for an association between IL‐1 loci polymorphisms with increased gastric mucosal levels of IL‐1β and an increased risk of developing GC in a Korean population. Polymorphisms of IL‐1A‐889, IL‐1B‐31, IL‐1B‐511 and IL‐1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL‐1β cytokine was measured using an ELISA. The frequencies of IL‐1A, IL‐1B‐511, IL‐1B‐31 and IL‐1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal‐type GC showed a higher frequency of IL‐1B‐31T homozygotes (OR = 2.2; 95% CI = 1.1–4.3) compared with controls. Risk was also significantly increased in these patients for IL‐1B‐31T homozygotes compared with patients with diffuse‐type GC (OR = 3.4; 95% CI = 1.5–7.7). As in Caucasian populations, linkage disequilibrium between IL‐1B‐31 and IL‐1B‐511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL‐1B‐31T/IL‐1B‐511C) was opposite (IL‐1B‐511T/IL‐1B‐31C). Mucosal IL‐1β levels in H. pylori‐infected GC patients were higher in patients homozygous for IL‐1B‐31T compared with IL‐1B‐31C/T and IL‐1B‐31C/C. Thus, the combined effects of H. pylori infection and IL‐1B‐31T/IL‐1B‐511C polymorphisms with enhanced mucosal IL‐1β production contributed to the development of intestinal‐type GC in this Korean population. © 2004 Wiley‐Liss, Inc.
Human papillomavirus type 18 variants: Histopathology and E6/E7 polymorphisms in three countries
Authors: De Boer Marjon A. , Peters Lex A.W. , Aziz Mohammed Farid , Siregar Budiningsih , Cornain Santoso , Vrede M. Albert , Jordanova Ekaterina S. , Fleuren Gert Jan
Published: November 2004

In cervical cancer, human papillomavirus type 18 (HPV 18) and HPV 16 are predominantly related to adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs), respectively. Here, we studied whether the geographically distributed HPV intratypic variants are also associated with histologically different tumors. A total of 44 HPV 18‐positive and 91 HPV 16‐positive cervical carcinomas from Indonesian, Surinamese and Dutch patients were histologically classified using hematoxilin and eosin, periodic acid Schiff plus and Alcian Blue staining. Samples were sequenced and intratypic variants were classified into the known phylogenetic branches. The Asian Amerindian HPV 18 variant was observed in 56% of ADCs compared to 15% of SCCs (p < 0.006). The African HPV 18 variant was exclusively found in SCCs. By sequencing the HPV 18 E6 and E7 open reading frames, we found predicted amino acid changes only in 8 samples. Two amino acid changes were consistent throughout the African branch. In HPV 16‐positive tumors, we did not find a specific linkage between intratypic variants and histopathology. We conclude that HPV 18 intratypic variants are differentially associated with adenocarcinoma and squamous cell carcinoma of the cervix. The findings described here stress the biologic significance of intratypic HPV variants and might help explaining differences in the pathogenesis of cervical ADCs and SCCs. © 2004 Wiley‐Liss, Inc.
Proximity of first intercourse to menarche and the risk of human papillomavirus infection: A longitudinal study
Authors: Collins Stuart I. , Mazloomzadeh Saeideh , Winter Heather , Rollason Terry P. , Blomfield Penny , Young Lawrence S. , Woodman Ciaran B.J.
Published: November 2004

Cross‐sectional studies have suggested that compared with women who delay the start of their sexual career, those who first have intercourse soon after menarche are more susceptible to cervical human papillomavirus (HPV) infection and thus have a greater risk of cervical neoplasia. We describe, using longitudinal observations, how the risk of infection with HPV varies with the interval between menarche and first intercourse in 474 women aged 15–19 recruited within 12 months of first intercourse and before the acquisition of a second sexual partner. One hundred forty‐five women became HPV‐positive; the cumulative risk of HPV infection 3 years after first intercourse was 45.0% (95% CI = 37.9–51.2). In univariate analyses, the hazards ratio (HR) of HPV infection increased significantly with age at first intercourse (HR = 1.212 per year; 95% CI = 1.050–1.398), partner age (HR = 1.084 per year; 95% CI = 1.045–1.125) and when women reported a sexually experienced partner (HR = 2.794; 95% CI = 1.804–4.326); the interval between menarche and first intercourse was a significant predictor of infection, with an increase in the HR of 12.9% for every year of increase in this interval (95% CI = 2.1%–24.9%). In a multivariate analysis, compared with women who first had intercourse within 3 years of menarche, those who postponed first intercourse beyond this time had a greater risk of infection (HR = 1.581; 95% CI = 1.113–2.245) after controlling for age and sexual experience of partner. © 2004 Wiley‐Liss, Inc.
Cadmium‐induced malignant transformation in rat liver cells: Role of aberrant oncogene expression and minimal role of oxidative stress
Authors: Qu Wei , Diwan Bhalchandra A. , Reece Jeffrey M. , Bortner Carl D. , Pi Jingbo , Liu Jie , Waalkes Michael P.
Published: November 2004

Our study examined the role of oxidative stress and aberrant gene expression in malignant transformation induced by chronic, low‐level cadmium exposure in non‐tumorigenic rat liver epithelial cell line, TRL 1215. Cells were cultured in 1.0 μM cadmium (as CdCl2) for up to 28 weeks and compared to passage‐matched control cells. The level of cadmium used for transformation produced no evidence of increased superoxide (O2− ·) or hydrogen peroxide (H2O2) levels in the early stages of exposure (≤24 hr). The chronic cadmium exposed liver epithelial cells (CCE‐LE) were hyperproliferative with a growth rate about 3‐fold higher than control cells. CCE‐LE cells produced highly aggressive tumors upon inoculation into mice confirming malignant transformation. Analysis of cellular reactive oxygen species (ROS) showed that CCE‐LE cells possessed markedly lower basal levels of intracellular O2− ·and H2O2 and were very tolerant to high‐dose (50 μM) cadmium‐induced ROS. Time course studies showed the production of ROS by high‐dose cadmium was abolished well in advance of malignant transformation. In contrast, marked overexpression of the oncogenes c‐myc and c‐jun occurred in transformed CCE‐LE cells as evidenced by up to 10‐fold increases in both transcript and protein. A significant increase in DNA‐binding activity of the transcription factors AP‐1 and NF‐κB occurred in CCE‐LE cells. Increases in oncogene expression and transcription factor activity occurred concurrently with malignant transformation. Thus, cadmium‐induced ROS occurs as an early, high‐dose event but is abolished well in advance of malignant transformation. Low‐level chronic cadmium triggers oncogene overexpression possibly by altering critical transcription factor activity. Such changes in cellular gene expression likely culminate in the loss of growth control and cadmium‐induced neoplastic transformation in CCE‐LE cells, whereas generation of ROS by cadmium seemed to play a minimal role in this transformation. © 2004 Wiley‐Liss, Inc.
Direct determination of resin and fatty acids in process waters of paper industries by liquid chromatography/mass spectrometry
Authors: Rigol A. , Latorre A. , Lacorte S. , Barceló D.
Published: November 2004

Liquid chromatography/mass spectrometry (LC/MS)‐based methods were developed for the analysis of 10 resin acids and five fatty acids in process waters of paper industries. No fragmentation of target compounds was observed using atmospheric pressure chemical ionization (APCI) with negative ionization. The [M − H]− ion permitted the individual quantification of fatty and aromatic resin acids, whereas the non‐aromatic resin acids presented a single and common ion at m/z 301. Separation with two columns of different polarity permitted peak confirmation. The method that used a C8 column with 2‐propanol in the mobile phase allowed a certain separation and identification of the non‐aromatic resin acids, whereas the method using a C18 column provided detection limits 10‐fold lower for fatty acids. Limits of detection were 0.10 ng for all compounds. Direct sample introduction was compared with liquid–liquid extraction, with similar recoveries (70–101%). Whereas slightly lower detection limits were obtained with liquid–liquid extraction, better reproducibility was observed for direct sample introduction. Resin and fatty acids were determined in process waters of several paper industries. Palmitic, dehydroabietic and non‐aromatic resin acids were encountered in most water samples, at levels between 22 and 403 µg l−1. LC/MS with direct sample introduction was found to be a good alternative to traditional liquid–liquid extraction and gas chromatography for the analysis of such compounds since no derivatization was required and sample manipulation was minimal. Copyright © 2003 John Wiley & Sons, Ltd.
Associative properties of perfluorooctyl end‐functionalized polystyrene–poly(ethylene oxide) diblock copolymers
Authors: Boschet Frédéric , Branger Catherine , Margaillan André , Hogen‐Esch Thieo E
Published: November 2004

The synthesis of 2,2,3,3‐tetrahydro‐perfluoroundecanoyl end‐functionalized polystyrene–poly(ethylene oxide) block (PS‐block‐PEO‐RF) copolymers and their matching PS‐block‐PEO diblock copolymers was carried out by sequential anionic polymerization. Viscometry and 19F NMR studies show that the PS‐block‐PEO copolymers, in contrast to their matching PS‐block‐PEO‐RF copolymers, exhibit a micellar rather than the associative behavior seen for the latter. However, the presence of an excess of fluorinated acid, used for end‐functionalization, produces a reduction of the associative behavior above the overlap concentration, with the fluorinated acid acting like a surfactant. A competition may also occur between PS—and RF—mediated micellization. Copyright © 2004 Society of Chemical Industry