bluuebunny/crossref_metadata_2025 huggingface dataset:
Does Practice Modify the Relationship between Postural Control and the Execution of a Secondary Task in Young and Older Individuals?
Authors: Dault Mylène C. , Frank James S.
Published: May 2004

Background: Numerous daily activities require performing more than one task simultaneously, such as standing while engaging in a conversation. Recent studies have shown that postural control may be degraded when individuals are asked to perform a secondary task and that this effect seems to be more pronounced in older adults. Since various types of secondary tasks have been used in postural control studies, the novelty of the tasks may partly explain why dual-task interference occurs. It is known that novel tasks require greater attentional resources and thus may interfere to a greater extent with the performance of another task. Therefore, by practicing this dual-task situation, interference could perhaps be diminished. Since the dual-tasking efficiency is reduced with aging, practice could be very beneficial to older adults. Objectives: The main goal of this study was to examine whether practice could modify the changes seen in postural sway when individuals are asked to perform a secondary task while maintaining upright stance and whether older individuals could benefit to a greater extent from practice than would young individuals. The second goal was to examine the dual-task performance in young versus older adults and to determine whether older individuals benefit equally or to a greater extent from practice as compared with young individuals. Methods: Young and older individuals were asked to stand on a force platform while performing a secondary task or no task. The secondary task condition was repeated six times to examine the effects of practice. Results: Practice did not modify the performance of postural sway, but did lead to an increase in speed of execution of the secondary task for both groups equally. In young participants, the amplitude of sway was decreased, and the frequency of sway was increased, indicating an increased stiffness when performing the cognitive task. Older participants showed increased amplitude of sway and increased frequency of sway in the mediolateral direction only. Conclusions: Since the dual-task condition was only repeated six times, it could be hypothesized that the effect of practice would be greater, if more trials were added or if more practice sessions were included. More research is needed to verify this hypothesis.
Assessing Life Expectancies of Institutionalized Older Persons in Hong Kong
Authors: Hui Elsie , Wong Eric M.C. , Woo Jean
Published: May 2004

Background: In Hong Kong, it has been projected that, by the year 2010, there will be 0.86 million persons aged 65 or older. The demand for residential care places continues to rise. Information on the survival of older persons will allow better management of care in institutional settings. Objective: The Weibull model was developed to predict the 18-month survival of a group of Chinese nursing home residents. Methods: In this prospective cohort study, 590 older residents from four nursing homes with different levels of care were enrolled. The main outcome measure was survival at 18 months. Information on subject demographics, clinical data and disability levels as measured by the Patient Assessment Instrument (PAI) was collected at baseline. Life expectancies were derived from accelerated failure time models. Results: Independent predictors of decreased survival derived from the Weibull model included increased age, male gender, diagnosis of cancer, presence of malnutrition and functional dependence. Significant interaction was observed between male gender and PAI score. The goodness of fit of the model was satisfactory. Conclusions: From this study, the model for predicting life expectancy in nursing home residents can assist policy makers in planning long-term care. It can also guide clinicians to make more appropriate management decisions for their older patients.
Effect of Aging on Visual Shape Distortion
Authors: Rivest Josée , Kim Ji Soo , Intriligator James , Sharpe James A.
Published: May 2004

Background: Individuals experience a visual illusion created by shape interaction: when two shapes are presented successively and briefly, the form of the second (test) shape appears distorted due to the form of the first (prime) shape; this shape interaction is called the shape distortion effect. While age-related deterioration in performance is found in various aspects of visual perception, the effect of aging on the shape distortion effect has not been evaluated. Objective: The purpose of this study is to determine the effect of aging on the shape distortion effect. Methods: We measured the perception of briefly presented elementary shapes and of the shape distortion effect in 29 healthy volunteers, with ages ranging from 18 to 83 years. For each shape interaction trial, a prime rectangle was presented (vertical or horizontal) for 45 ms, followed by an interstimulus interval for 135 ms, a test circle for 60 ms and finally a random dot mask for 300 ms. The test circle was presented in each quadrant of the visual field. The prime rectangle was flashed either at the same position as the test circle (0° offset, intrahemifield) or 11° apart, displaced horizontally in the opposite hemifield (11° offset, interhemifield). In the elementary-shape trials, there was no prime, and the test shape was a circle or an ellipse. Using the method of adjustment, the percent elongation [(longer diameter – shorter diameter)/(shorter diameter) ×100] of the reproduced ellipse was computed. Results: The mean percent elongation in response to the elementary shapes did not vary with increasing age. The shape distortion effect decreased significantly with increasing age during both intra- and interhemifield conditions. The mean shape distortion effect was larger for the intrahemifield condition than for the interhemifield one. Conclusion: The shape distortion effect decreases with advancing age while the perception of elementary shapes does not. These results indicate a severer age-related dysfunction of the cerebral processing of shape interaction than that of elementary-shape perception.
Decline of Vertical Gaze and Convergence with Aging
Authors: Oguro Hiroaki , Okada Kazunori , Suyama Nobuo , Yamashita Kazuya , Yamaguchi Shuhei , Kobayashi Shotai
Published: May 2004

Background: Disturbance of vertical eye movement and ocular convergence is often observed in elderly people, but little is known about its frequency. Objective: The purpose of this study was to investigate age-associated changes in vertical eye movement and convergence in healthy elderly people, using a digital video camera system. Methods: We analyzed vertical eye movements and convergence in 113 neurologically normal elderly subjects (mean age 70 years) in comparison with 20 healthy young controls (mean age 32 years). The range of vertical eye movement was analyzed quantitatively and convergence was analyzed qualitatively. Results: In the elderly subjects, the angle of vertical gaze decreased with advancing age and it was significantly smaller than that of the younger subjects. The mean angle of upward gaze was significantly smaller than that of downward gaze for both young and elderly subjects. Upward gaze impairment became apparent in subjects in their 70s, and downward gaze impairment in subjects in their 60s. Disturbance in convergence also increased with advancing age, and was found in 40.7% of the elderly subjects. Conclusion: These findings indicate that the mechanisms of age-related change are different for upward and downward vertical gaze. Digital video camera monitoring was useful for assessing and monitoring eye movements.
Heart Rate and Blood Pressure Changes during Gastroscopy in Healthy Older Subjects
Authors: Ross Ruth , Newton Julia L.
Published: May 2004

Background: Previous studies uncontrolled for co-morbidity have shown increased heart rate and decreased oxygenation during gastroscopy in older people. One previous study of selected younger patients suggested that changes in blood pressure were more pronounced in non-premedicated patients. Aims: To prospectively examine blood pressure and heart rate responses during gastroscopy in healthy older people uninfluenced by medication or co-morbidity. Methods: Blood pressure and heart rate were monitored continuously in consecutive unselected patients attending for gastroscopy carried out by one endoscopist. Results: Thirty-seven patients were included with a mean age of 51.5 years (95% CI: 17–89); 10 patients were over the age of 65. During gastroscopy there were large increases in blood pressure and heart rate, with maximum changes occurring predominantly at intubation in the younger age group. Typically, increases in blood pressure in the older group occurred later in the procedure and were more sustained. Mean (95%CI) maximum changes in systolic blood pressure were more profound in those sedated [73 (55–91) mm Hg] compared to those having throat spray [47 (34–60) mm Hg; p < 0.05]. Maximum changes in heart rate during gastroscopy became significantly smaller with advancing age in those having throat spray (p = 0.03) but not in those receiving sedation. Conclusions: Gastroscopy stimulates blood pressure and heart rate changes that are greatest in those sedated. Further studies of the effect of gastroscopy upon blood pressure are required, particularly in older patients, the group regarded as at increased risk from complications.
Role of Mitochondrial Deterioration in Physiological and Pathological Brain Aging
Authors: Bertoni-Freddari Carlo , Fattoretti Patrizia , Giorgetti Belinda , Solazzi Moreno , Balietti Marta , Meier-Ruge William
Published: May 2004

Background: Mitochondria are widely reported to occupy a unique role in modulating cell viability, senescence and death. This is consistently supported by the multiple functions of these organelles. In addition to providing the energy for the myriad of cellular performances, mitochondria are involved in regulating thermogenesis, calcium buffering, integration of pro- and anti-apoptotic signals. Objective: To stress the significant importance of subtle, continuous and permanent mitochondrial alterations as key events in physiological aging and as unfavourable determinants of age-related neurodegenerative diseases. Results: Any dysfunction of these organelles may constitute a serious threat for cellular health status and survival, particularly of post-mitotic nerve and muscle cells. Mitochondrial deterioration may affect discrete features of the organelles (such as their structural dynamics, genetics and physiology) and lead to a progressive functional impairment. Conclusions: A variety of mitochondrial tasks, while hampering the possibility to recover the organelles’ dysfunctions, offer different and reliable opportunities for therapeutic interventions.
Induction of Manganese-Superoxide Dismutase by YS 51, a Synthetic 1-(β-Naphtylmethyl)6,7-Dihydroxy- 1,2,3,4-Tetrahydroisoquinoline Alkaloid
Authors: Seo Han Geuk , Kim Hyo Jung , Ko Young Shin , Pyo Hyang Sam , Kang Young Jin , Lee Young Soo , Park Min Kyu , Yun-Choi Hye Sook , Chang Ki Churl
Published: May 2004

The effect of YS 51, a synthetic 1-(β-naphtylmethyl)6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline alkaloid, on the expression of manganese-superoxide dismutase (Mn-SOD), an antioxidant enzyme, was examined in sheep pulmonary artery endothelial cells (SPAEC) and a human cervical carcinoma cell line (Hela). YS 51 alone or in combination with cytokines enhanced the expression of Mn-SOD mRNA in SPAEC and Hela cells. YS 51 also showed synergistic effects on the induction of Mn-SOD mRNA with phorbol-12-myristate-13-acetate (TPA) and/or tumor necrosis factor-α (TNF-α). In Hela cells, the induction of Mn-SOD mRNA by YS 51 was in a time- and dose-dependent manner and the expression of Mn-SOD mRNA was increased to a maximum of 4-fold in 9 h. Enhancement of Mn-SOD mRNA by YS 51 was completely abolished by actinomycin D but not cycloheximide, suggesting that the induction of Mn-SOD mRNA byYS 51 is independent of new protein synthesis. Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2′-amino-3′-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase. Also, YS 51 induced the phosphorylation activity of JNK in a time-dependent manner without affecting the phosphorylation activity of the extracellular signal-regulated kinase 1 (ERK1) and p38 MAP kinase. These results implicated that the JNK pathway appears to play a crucial role in mediating the YS 51-induced Mn-SOD gene expression, and that up-regulation of Mn-SOD would contribute to the anti-inflammatory actions mediated by YS 51.
Vasoconstrictor Responses to 5-Hydroxytryptamine in the Autoperfused Hindquarters of Spontaneously Hypertensive Rats
Authors: Calama E. , Morán A. , Ortiz de Urbina A.V. , Martín M.L. , San Román L.
Published: May 2004

In this work we studied the responses and receptors involved in the effects of intra-arterial 5-hydroxytryptamine (5-HT) in the in situ autoperfused hindquarters of spontaneously hypertensive rats (SHR). Intra-arterial administration of the highest doses (50–1,000 ng/kg) produced a vasoconstrictor effect that was inhibited by ritanserin (a selective 5-HT2 receptor antagonist), SB 206553 (a selective 5-HT2B/2C receptor antagonist) and spiperone (a nonspecific 5-HT1/2A receptor antagonist), and was mimicked by α-methyl-5-HT (a selective 5-HT2 receptor agonist) and m-CPP (a selective 5-HT2C receptor agonist), but not by the intra-arterial administration of BW 723C86, a selective 5HT2B receptor agonist. SB 206553 and spiperone inhibited α-methyl-5HT-induced vasoconstriction in the hindquarters of SHR. Our data suggest that the vasoconstrictor response induced by 5-HT in the autoperfused hindquarters of SHR is mainly mediated by the activation of 5-HT2A and 5-HT2C receptors.
Protein Kinase C Regulates α2A/D-Adrenoceptor Constitutive Activity
Authors: Zhu Qingbing , Qi Lai-Jun , Shi Anguo , Abou-Samra Abdul , Deth Richard C.
Published: May 2004

We investigated a possible role for protein kinases in the constitutive activity of α2A/D adrenoceptors in membranes from transfected PC12 cells, using a [35S]GTPγS binding assay. After treatment of intact cells with various protein kinase inhibitors, constitutive activity was assessed by the reduction in basal GTP binding caused by the inverse agonist rauwolscine (RAU). Inhibitors of protein kinase C (PKC) caused the loss of RAU-sensitive GTP binding, while inhibitors of other protein kinases were ineffective. Anti-Gα antibody treatments showed that constitutive α2A/D-receptor activity is directed toward different G proteins than agonist-stimulated activity. T373A mutant receptors exhibited increased constitutive activity, including a component that was insensitive to PKC inhibition. Since T373 is located within a putative Gi/o activator sequence, these results suggest that PKC-dependent phosphorylation of T373 increases α2A/D-adrenergic receptor constitutive activity and causes a switch in G protein preference.
Effects of Phosphodiesterase V Inhibition on Nitric Oxide-Mediated Relaxation Responses in Guinea Pig Trachea
Authors: Tuncel Başak I. , Şadan Gülay
Published: May 2004

In the present study, we aimed to evaluate the effects of PDE V inhibition on NO-mediated relaxation responses in isolated guinea pig trachea. Under the NANC conditions, tracheal preparations were contracted with histamine (100 µm/l). When contraction had reached a plateau, relaxation responses to electrical field stimulation (EFS, 60 V, 0.5 ms, 5–10 Hz) were determined before and after incubation of the tracheal ring with L-NAME (1 mmol/l), a NO synthase inhibitor. L-NAME significantly inhibited the relaxation responses and this inhibitory effect was reversed by L-arginine (1 mmol/l), a precursor of NO, but was not affected by D-arginine. In addition, cumulative application of the NO donors, 3-morpholino-sydnonimine (SIN-1) and sodium nitroprusside (SNP), caused concentration-dependent relaxation of tissues precontracted with histamine. The selective PDE type V inhibitor zaprinast at EC50 concentration (30 µmol/l) significantly potentiated EFS-induced NANC relaxations and relaxant responses to SIN-1 and SNP. In conclusion, these data support the hypothesis that NO is a mediator of NANC relaxations of guinea pig tracheal rings and PDE V inhibition potentiates NO-mediated relaxation.
Keratin 2e: A Marker for Murine Nipple Epidermis
Authors: Mahler Bryon , Gocken Todd , Brojan Marija , Childress Sue , Spandau Dan F. , Foley John
Published: May 2004

Mesenchyme-derived signals influence the unique keratinization and appendage formation programs in specialized skin regions. Interactions between primary mammary mesenchyme and epidermal cells result in the formation of the nipple; however, it is unclear whether this represents a site of regionally specialized epidermis. We profiled the ultrastructure and keratin expression of the murine nipple, and the ventral skin of the K14-parathyroid hormone-related protein (PTHrP) transgenic mouse, which models nipple formation. We found the murine nipple and ventral K14-PTHrP epidermis display expanded suprabasal and granular layers, as well as a thickened cornified layer compared to ventral skin of wild-type littermates. We also observed increased levels of filaggrin in extracts from the ventral epidermis of the K14-PTHrP mouse when compared to that of wild-type littermates. Keratin 2e, previously reported to be expressed in various specialized epidermal sites in the mouse, is expressed in the nipple and the ventral skin of the K14-PTHrP mouse. Keratinocytes grown from the ventral epidermis of the K14-PTHrP mouse or wild-type littermates exhibited identical expression of epidermal markers in vitro, suggesting that the modulated differentiation profile observed in the nipple or the ventral K14-PTHrP skin was dependent on interactions with fibroblasts. The lack of appendages, altered stratification pattern and expression of a specialized keratin suggests that the murine nipple is an example of regionally specialized epidermis.
Pattern of Myosin Heavy Chain Isoforms in Different Fibre Types of Canine Trunk and Limb Skeletal Muscles
Authors: Štrbenc M. , Smerdu V. , Županc M. , Tozon N. , Fazarinc G.
Published: May 2004

The aim of this study was to determine the pattern of myosin heavy chain (MHC) isoform expressions within the muscle fibres of functionally diverse trunk and limb dog muscles using monoclonal antibodies that are specific to MHC isoforms. We found that three MHC isoforms are expressed in dog skeletal muscles. The pattern of their expressions determined the existence of ‘pure’ fibres, i.e. I and IIa, both expressing only one MHC isoform, and ‘hybrid’ fibres, i.e. I/IIa and IIa/x, that co-expressed two MHC isoforms. While the MHCI, MHCIIa and MHCI/IIa fibres corresponded to the myofibrillar ATPase type fibres I, IIA and IIC, respectively, the hybrid MHCIIa/x fibres mostly behaved like the IIDog fibre type in myofibrillar ATPase reaction as described by Latorre et al. [J Anat 1993a;182:329–337]. No pure MHCIIx fibres were found. Though MHCIIa/x fibres were quite numerous, their presence varied not only within different muscles but within the same muscle of different animals as well. We suggest that the discrepancies in the classification of fibre types according to their myofibrillar ATPase activity between different studies of dog skeletal muscles are probably a consequence of the variable content of the MHCIIa and MHCIIx isoforms in the MHCIIa/x hybrid fibres. Estimating the histochemical metabolic profile of fibres we found that in all fast fibres oxidative-glycolytic metabolism prevailed, whereas in slow fibres oxidative metabolism was more pronounced.
Apocrine Glands in the Eyelid of Primates Contribute to the Ocular Host Defense
Authors: Stoeckelhuber Mechthild , Stoeckelhuber Beate M. , Welsch Ulrich
Published: May 2004

Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon. In addition, we tested the primate glands of Moll with antibodies against antimicrobial proteins, cytoskeletal proteins and the androgen receptor. The glands of Moll differ in abundance and distribution in different monkeys. In the common marmoset, a representative of the New World monkeys, Platyrrhini, the apocrine glands are frequently found at the lid margin and in the overlying epidermis of the lid. In the rhesus monkey and the hamadryas baboon, representatives of Old World monkeys, Catarrhini, apocrine glands are rarer and located predominantly at the margin of the lid. The immunohistochemical analysis indicates the presence of a variety of antimicrobial proteins, e.g. lysozyme, β-defensin-2, adrenomedullin, lactoferrin, and IgA, in these glands. Interestingly, there are basically no androgen receptors in the nuclei of apocrine glands at the lid margin in all three monkey species. In the common marmoset, however, androgen receptors are found in apocrine glands of the overlying epidermis of the lid. We speculate that the glands of Moll are derived from apocrine glands as found in the skin of the entire body in New World monkeys which developed at the lid margins of higher primates and humans into specialized glands secreting agents of host defense in the eye.
Reevaluation of the Morphological Parameters according to 11 Different Duplications of the Fetal Vertebral Artery at Prevertebral (V1) and Intracranial (V4) Parts
Authors: Vasović Ljiljana P.
Published: May 2004

It is noted that the vertebral artery lies buried in a sea of generalities, prejudices, fear, and ignorance in the clinical literature. This fact is the reason why this observation is based on 11 cases, selected from 206 fetal cases, of various duplications of the vertebral artery. Aberrant or anastomotic vessels are illustrated and their definition is largely modified according to the recent anatomic terminology. Duplications of the vertebral artery indicate the ‘segmental duplication’ as a first form, and the presence of an abnormal ‘fenestra’ in the vessel’s trunk as a second form of duplication. There are 9 (5 at prevertebral and 4 at intracranial parts) or 4.36% cases of ‘segmental duplication’ of the vertebral artery and 2 or 0.98% ‘arteria vertebralis unifenestrata’ at the intracranial part of all 206 cases. Successive morphological parameters of aberrant or anastomotic vessels are described and discussed according to personal cases and cases in the literature.
Pentoxifylline in the Treatment of Actinic Prurigo
Authors: Torres-Alvarez Bertha , Castanedo-Cazares Juan Pablo , Moncada Benjamin
Published: May 2004

Background: Actinic prurigo (AP) is a chronic familial photodermatosis usually seen in Latin-American Mestizo and Indian populations. It frequently begins in childhood and is more prevalent in females. The pathogenesis of AP has not been clearly elucidated, but previous studies have suggested an immune-mediated condition. Many drugs have been employed to treat AP patients with variable success. Objective: To assess the clinical efficacy of pentoxifylline (PTX) in the treatment of AP patients by measuring its effects on lesions and pruritus. Methods: 10 patients with severe AP were included to receive PTX in a 6-month open-label uncontrolled study. Results: Clinical improvement of lesions was evident in all patients. Relief in pruritus was evident after 1 month of treatment and was maintained while receiving PTX. Five patients were followed up for 2 years, 2 obtained complete remission, and 3 had an important reduction in the use of corticosteroids. Conclusion: PTX was useful in the treatment of our actinic prurigo patients. It may induce a complete or partial remission of lesions and allow a decrease in the use of topical corticosteroids.
Diagnostic and Surgical Accuracy and Economic Aspects of Dermatological Surgery – A Pilot Study
Authors: Skaria A.M.
Published: May 2004

Background: Good skin care for oncological dermatological patients includes efficacious excision to achieve tumour control and economically reasonable costs. This field concerns dermatologists as much as other surgical specialities. Methods: Of 944 excisions and biopsies, we studied 114 epidermal carcinomas excised by plastic surgeons and dermatologists. This allowed us to compare the accuracy concerning oncological surgical aspects as well as the extrapolated costs produced by these two specialities. Results: Dermatologists are significantly more accurate concerning total excision of epidermal tumours compared to plastic surgeons. Conclusion: From an economic point of view, plastic surgeons are increasingly more expensive than dermatologists. Most expenses are due to the use of a hospital operating room.
c-kit Mutation in Generalized Lentigines Associated with Gastrointestinal Stromal Tumor
Authors: Shibusawa Y. , Tamura A. , Mochiki E. , Kamisaka K. , Kimura H. , Ishikawa O.
Published: May 2004

We describe the case of a 59-year-old Japanese woman presenting with generalized lentigines without systemic anomalies. She had a medical history of gastrointestinal stromal tumors (GISTs), in which gain-of-function mutations of the c-kit gene had recently been found. We detected a point mutation at codon 557 in exon 11 of leukocyte DNA from the patient. The stem cell factor-type III receptor tyrosine kinase pathway plays important roles in the regulation of melanocyte proliferation and differentiation. We speculate that the generalized lentigines of the patient may be caused by melanocyte proliferation due to the c-kit gene mutation.
CCR4 Expression by Atypical T Cells in Systemic Pilotropic Lymphoma: Its Behavior under Treatment with Interferon Gamma, Topical PUVA and Systemic Retinoid
Authors: Fujimura Taku , Aiba Setsuya , Yoshino Yumiko , Kuroki Shigeru , Kimura Yutaka , Kikuchi Katsuko , Kunii Takahide , Matsunaga Jun , Matsushima Kouji , Tagami Hachiro
Published: May 2004

We describe an 88-year-old Japanese patient with pilotropic T cell lymphoma involving the peripheral blood as well as lymph nodes. This patient presented with multiple red follicular papules, confluent, infiltrated erythematous plaques and nodules. Moreover, he was conspicuous for the presence of total alopecia of the scalp and eyebrows. Histopathologically, the lesional skin showed dense follicular and perifollicular infiltrates of atypical lymphocytes. The flow cytometry disclosed the presence of weakly CD4+ CCR4+ cell populations that would not be detected in the peripheral blood from healthy controls. The patient responded well to topical PUVA and systemic etretinate (retinoid-PUVA) and intravenous IFN-γ. Parallel with the decrease in atypical cells in the peripheral blood, the percentage of weakly CD4+ CCR4+ T cells declined. However, about 1 week after we discontinued this treatment because of the side effects, the lymph node swelling became prominent, and, 4 weeks later, the patient died before restarting any specific chemotherapy.
Dermoscopy for the in vivo Detection of Sarcoptes scabiei
Authors: Prins C. , Stucki L. , French L. , Saurat J.-H. , Braun R.P.
Published: May 2004

We report the case of an 80-year-old patient who had intense pruritus which did not respond to a 3-month treatment with topical corticosteroids. On dermoscopy examination of the excoriations, we found the typical dermoscopic aspect of the scabies mite at a distance. Dermoscopy allows identifying a triangular structure which corresponds to the anterior section of the mite including the mouth part and the 2 pairs of front legs. This aspect has been described as resembling a jetliner with its trail, a delta glider or a spermatozoid. Traditional diagnostic methods for scabies failed in this case because the mites were at a distance from the burrows. This was due to the fact that the reaction to the mite was less pronounced and the diagnosis is frequently missed. Dermoscopy is a useful tool for the diagnosis of scabies either as a diagnostic test or to guide the traditional diagnostic tests.
Progressive Respiratory Failure in Paraneoplastic Pemphigus Associated with Chronic Lymphocytic Leukemia
Authors: Brönnimann M. , von Felbert V. , Streit M. , Hunziker T. , Braathen L.R.
Published: May 2004

A 70-year-old Caucasian man with chronic lymphocytic leukemia suffered from widespread, histologically proven cutaneous lichen planus responding to topical corticosteroids. 2 years later, he presented with painful erosive stomatitis and increasing dyspnea. Histology, direct and indirect immunofluorescence were diagnostic for paraneoplastic pemphigus. A full diagnostic workup could not disclose the cause of the progressive respiratory insufficiency. Despite aggressive treatment of the lymphocytic leukemia and the paraneoplastic pemphigus, the patient died 3 months after diagnosis. Paraneoplastic pemphigus may lead to pulmonary failure which is refractory to treatment and has a fatal outcome.
Subcutaneous Infection with Mycobacteriumabscessus in a Renal Transplant Recipient
Authors: Prinz B.M. , Michaelis S. , Kettelhack N. , Mueller B. , Burg G. , Kempf W.
Published: May 2004

Transplant recipients show a high incidence of infections, often with atypical manifestations mainly because of drug-related immunosuppression. Mycobacterial infections can be life-threatening in immunosuppressed patients due to the risk of dissemination. There have been only few reports of cutaneous infections with Mycobacterium abscessus among immunosuppressed patients. We present a rare case with a sporotrichoid skin infection with M. abscessus in a renal recipient. The value of immunohistochemical detection of mycobacteria using an anti-BCG antibody in the diagnostic work-up skin biopsies is demonstrated. Long-term antibiotic treatment resulted in complete remission, although recurrences with atypical presentation were observed.
Pancreatic Panniculitis in a Patient with an Acinar Cell Cystadenocarcinoma of the Pancreas
Authors: Beltraminelli H.S. , Buechner S.A. , Häusermann P.
Published: May 2004

We describe a 60-year-old man with pancreatic panniculitis associated with arthritis and peripheral eosinophilia in whom the skin symptoms led to a diagnosis of an underlying acinar cell cystadenocarcinoma. The panniculitis involved initially the legs, but soon thereafter lesions developed on the trunk and upper extremities. In the literature, only 5 cases of pancreatic acinar cell cystadenocarcinoma have been reported, none of these in association with panniculitis.
Giant Fibrokeratoma of the Heel
Authors: Bron C. , Noël B. , Panizzon R.G.
Published: May 2004

We describe a 77-year-old patient with a giant acquired fibrokeratoma on the heel. The size and the localization of the tumor was unusual. Simple shave excision was curative.
Localized Childhood Vulval Pemphigoid Treated with Tacrolimus Ointment
Authors: Lebeau S. , Mainetti C. , Masouyé I. , Saurat J.-H. , Borradori L.
Published: May 2004

Background: Localized vulval childhood pemphigoid is a rare variant within the pemphigoid group. Although its prognosis seems favorable, the best therapeutic strategy remains unclear. Observation: We here describe the case of an 8-year-old girl presenting with a 5-year history of relapsing vulval pain and lesions suggestive of lichen sclerosus. Clinical features, light microscopy and direct immunofluorescence microscopy were consistent with vulval cicatricial pemphigoid, although the autoantigen(s) involved could not be characterized. Her disease responded to treatment with topical tacrolimus ointment 0.1% within 3 months without any evidence for disease activity, except for slight residual scarring. After 12 months, her treatment was stopped without relapse. Conclusion: This observation suggests that in this rare immune-mediated blistering disease topical tacrolimus is an interesting therapeutic option without the adverse effects associated with topical steroids.
Lupus-Like Syndrome Associated with Statin Therapy
Authors: Noël Bernard , Panizzon Renato G.
Published: May 2004

Statins are among the most widely prescribed drugs. An increasing number of lupus-like syndrome has recently been reported with these lipid-lowering agents. We describe a new case associated with simvastatin therapy. The presence of anti-dsDNA antibodies in the serum is for the first time reported confirming that statins may also induce a systemic autoimmune reaction. Statin-induced lupus-like syndrome is characterized by the long delay between the beginning of therapy and the skin eruption. Antinuclear antibodies may persist for many months after drug discontinuation. The causal relationship may be therefore difficult to establish, and probably many cases are unrecognized. Early diagnosis may avoid unnecessary immunosuppressive therapy.
Nephrogenic Fibrosing Dermopathy Treated with Extracorporeal Photopheresis
Authors: Läuchli Severin , Zortea-Caflisch Claudia , Nestle Frank O. , Burg Günter , Kempf Werner
Published: May 2004

Nephrogenic fibrosing dermopathy (NFD) is a rare fibrosing skin disease of unknown etiology occurring in patients with terminal renal disease. It was first described in the year 2000. The histology of NFD shows an increased number of dendritic cells, fibroblasts and thickened collagen fibers resembling scleromyxedema. It can be distinguished from scleromyxedema by a different distribution pattern of the skin lesions with indurated plaques mainly on the extremities and the absence of paraproteinemia. As yet, no treatment for NFD has been proven to be uniformly efficient. We describe the case of a 40-year old patient with renal insufficiency who was treated with hemodialysis and who had undergone kidney transplantation. Two years after transplantation, she developed sclerodermiform brownish plaques on her extremities. The induration improved significantly after 4 cycles of extracorporeal photopheresis.
Familial Cutaneous Mycosis fungoides: Successful Treatment with a Combination of Gemcitabine and Alemtuzumab
Authors: Weder P. , Anliker M. , Itin P. , Bargetzi M.
Published: May 2004

We report a familial cutaneous T-cell lymphoma in father and son. After different treatment modalities without lasting responses, the son was treated with gemcitabine as single agent and due to insufficient effect with alemtuzumab monotherapy. Only after the two drugs had been combined did we observe a remarkable response of the skin lesions and disappearance of enlarged lymph nodes. The combined treatment with gemcitabine and alemtuzumab was well tolerated, and no increased toxicity was noted. The combination of these two active agents may provide an additional option in the treatment of cutaneous T-cell lymphoma.
Fulminant Herpetic Sycosis: Atypical Presentation of Primary Herpetic Infection
Authors: Campanelli A. , Marazza G. , Stucki L. , Abraham S. , Prins C. , Kaya G. , Piguet V. , Saurat J.-H.
Published: May 2004

Fulminant herpetic sycosis is a rare but well-known manifestation of herpes simplex virus (HSV) infection occurring in the context of viral recurrence in immunodepressed patients. We present here the case of a 32-year-old male patient, without notable medical history, who developed papulovesicular lesions of the beard accompanied by fever, painful cervical lymphadenopathy and odynophagia, with a clinical evolution that was initially unfavourable under antibiotic treatment. The diagnosis of herpetic sycosis was established by means of direct immunofluorescence and culture which confirmed positivity for HSV-1 and serologies compatible with a primary viral infection. No sign for a latent immune deficit was found at the time of investigations. The clinical evolution was rapidly favourable with administration of intravenous aciclovir for 1 week. To our knowledge, herpetic sycosis as a presentation of primary viral infection has not been reported previously. The possibility of a herpetic sycosis of the beard must be considered in the case of non-response to antibiotic or antifungal treatment.
Cutaneous Plasmablastic Lymphoma in an HIV-Positive Male: An Unrecognized Cutaneous Manifestation
Authors: Häusermann P. , Khanna N. , Buess M. , Itin P.H. , Battegay M. , Dirnhofer S. , Buechner S.A.
Published: May 2004

Plasmablastic lymphoma (PBL) is a rare and relatively new entity originally described in HIV-infected individuals. This subset of Epstein-Barr-virus (EBV)-related non-Hodgkin lymphomas is now regarded as a distinct clinicopathological category of AIDS-associated lymphomas occurring preferentially in the oral cavity and showing a poor prognosis. We describe for the first time an EBV-associated PBL with an isolated cutaneous distribution on the lower extremities in an HIV-infected heterosexual male and point to the unique clinical, morphological and immunophenotypic characteristics of this lymphoma. The patient presented with fast growing solid and livid nodules on both legs. The large, blastic tumor cells showed the following immunophenotype: CD138+, CD45+, CD20–, CD10–, CD3–, CD30–, bcl-2–, bcl-6–, LMP-1– and EMA–. The proliferation fraction (Mib-1) was >90%. EBV association was demonstrated by in situ hybridization (EBV-encoded RNAs 1/2). Polymerase-chain-reaction-based DNA analysis demonstrated a clonal IgH rearrangement in the absence of a bcl-2/IgH translocation. PBL in HIV patients may occur not only in the oral cavity, but can probably involve any other organs including the skin.
Cytochrome P-450 2D6*10 C188T Polymorphism Is Associated with Antipsychotic-Induced Persistent Tardive Dyskinesia in Chinese Schizophrenic Patients
Authors: Liou Ying-Jay , Wang Ying-Chieh , Bai Ya-Mei , Lin Chao-Cheng , Yu Shun-Chieh , Liao Ding-Lieh , Lin Ming-Wei , Chen Jen-Yeu , Lai I-Ching
Published: May 2004

Typical antipsychotic treatment had been postulated to be a risk factor for the susceptibility to tardive dyskinesia (TD). The cytochrome P-450 debrisoquine/sparteine hydroxylase (CYP2D6) metabolizes a majority of antipsychotics and exhibits various phenotypes on enzymatic activities from poor metabolizers to ultrarapid metabolizers. The various phenotypes are encoded by polymorphic genetic variants on the CYP2D6 gene. Although several studies had explored the association between the CYP2D6*10 C188T polymorphism, which encodes the phenotype intermediate metabolizers, and TD in Orientals, the findings were inconclusive. In the present study, we examined the relationship between the CYP2D6*10 C188T polymorphism and the TD occurrence in 216 Chinese schizophrenic patients (113 patients with TD and 103 patients without TD) and explored the correlation between the TD severity assessed by the Abnormal Involuntary Movement Scale (AIMS) and each C188T genotype in the 113 TD patients. Using logistic regression analysis, we found a modest association (p = 0.045) between TD and C188T genotypes. This positive finding was only observed in male patients (p = 0.001), but not in females. Our findings also support the correlation between AIMS scores and C188T polymorphism within the TD group after adjusting for confounding effects with the multiple regression analysis (p = 0.033). We concluded that the CYP2D6*10 C188T polymorphism may be associated with the susceptibility to the occurrence of TD induced by typical antipsychotics, especially in male patients, and may also be correlated with AIMS scores in TD patients.
Association Study of a Brain-Derived Neurotrophic Factor (Val66Met) Genetic Polymorphism and Panic Disorder
Authors: Lam Pok , Cheng Chih-Ya , Hong Chen-Jee , Tsai Shih-Jen
Published: May 2004

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, plays an important role in the development, maintenance and function of several neuronal systems. Recent studies have demonstrated that antidepressants, commonly used for panic disorder treatment, can increase central BDNF. In addition, animals with BDNF deficits have higher levels of anxiety when exposed to stressors in comparison to normal controls. The present study tested the hypothesis that the BDNF gene Val66Met polymorphism is associated with panic disorder. In this study, therefore, the incidence of this polymorphism was compared in 103 panic disorder patients and 180 normal controls. The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing the two groups. Furthermore, no association was demonstrated between this BDNF polymorphism and either mitral valve prolapse or agoraphobia in panic disorder patients. These findings suggest that the investigated BDNF polymorphism does not play a major role in the pathogenesis of panic disorder in this Chinese population. Further studies exploring the relationship between genetic variations of BDNF and the cerebral atrophy associated with, and antidepressant treatment response in, panic disorder may be appropriate.
No Association of a Functional Polymorphism in the Serotonin Transporter Gene Promoter and Anxiety-Related Personality Traits
Authors: Lang Undine E. , Bajbouj Malek , Wernicke Catrin , Rommelspacher Hans , Danker-Hopfe Heidi , Gallinat Jürgen
Published: May 2004

Serotonergic neurotransmission, which is involved in many psychiatric disorders, is mediated by the serotonin transporter protein. Gene coding for the serotonin transporter protein is designated SLC6A4, which has been differentially associated with anxiety-related behavioral traits and neuroticism in healthy subjects. To confirm the association between the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and anxiety-related personality traits, we examined 228 healthy unrelated participants (age 38.6 ± 12.8 years; 115 male, 113 female) of German origin, who were carefully examined with respect to psychiatric health. The self-ratable State-Trait Anxiety Inventory (STAI) and the NEO Five Factor Inventory (NEO-FFI) were performed. No significant association was observed between the 5-HTTLPR genotype and STAI 1 (state, χ2 = 0.82, p < 0.66, d.f. = 2), STAI 2 (trait, χ2 = 2.7, p < 0.25, d.f. = 2) and NEO-FFI scores of any of the 5 major axes, including neuroticism (χ2 = 3.35, p < 0.18, d.f. = 2) in all subjects. Given the small effect of this 5-HTT polymorphism on behaviour in previous studies, a lack of significant genotype differences in these tests could be due to considerable individual variability in these measures.
BanI Polymorphism of the Cytosolic Phospholipase A2 Gene and Mood Disorders in the Korean Population
Authors: Pae Chi-Un , Yu Hye-Sook , Kim Jung-Jin , Lee Chang-Uk , Lee Soo-Jung , Lee Kyoung-Uk , Jun Tae-Youn , Paik In-Ho , Serretti Alessandro , Lee Chul
Published: May 2004

Membrane phospholipid abnormalities have been proposed to be involved in the pathogenesis of mood disorders, and in signal transduction and neurotransmitter uptake. Cytosolic phospholipase A2 (cPLA2) is not only an essential enzyme in the metabolism of fatty acids but also in signaling process. Therefore, we examined the association between the BanI polymorphism of the cPLA2 gene and mood disorders. Sixty-two patients with major depressive disorder (MDD), 50 patients with bipolar I disorder (BID) and 117 healthy controls participated in this study. Genotyping was performed by using PCR-based methods. Genotype and allele distributions in MDD patients were significantly different from those of the controls. In particular, the A2 allele was associated with increased risk of MDD development (p = 0.007, odds ratio = 1.827; confidence interval = 1.141–2.927). However, the polymorphism was not different between BID patients and controls in genotype and allele distribution. This preliminary study indicates the need for further studies on the potential role of the cPLA2 gene polymorphism in the susceptibility to mood disorders.
Altered 5-HT2A and 5-HT4 Postsynaptic Receptors and Their Intracellular Signalling Systems IP3 and cAMP in Brains from Depressed Violent Suicide Victims
Authors: Rosel Pilar , Arranz Belén , Urretavizcaya Mikel , Oros Miguel , San Luis , Navarro Miguel Angel
Published: May 2004

Serotonin 5-HT2A and 5-HT4 binding parameters and their second messengers 1,4,5-inositol triphosphate (IP3) and cyclic adenosyl monophosphate (cAMP) were studied in the frontal cortex, hippocampus, caudate nucleus and amygdala of 19 control subjects and 19 antidepressant-free, violent suicide victims. A significantly higher number of 5-HT4 receptors and higher second messenger cAMP concentrations were found in the frontal cortex and caudate nucleus of the depressed suicide victims as compared with the control group. Furthermore, significantly increased 5-HT2A binding sites and IP3 concentrations were noted in the caudate nucleus of the suicide victims, together with a significantly reduced number of 5-HT2A binding sites, higher binding affinity and increased IP3 concentrations in the hippocampus. No significant alterations in 5-HT4 and cAMP or in 5-HT2A and IP3 concentrations were observed in the amygdala. The caudate nucleus of depressed suicide victims seems to be the brain region with the highest alteration of the serotonergic system, and hence with the most diagnostic sensitivity. Further studies on suicidality and depression should focus on the functionality of the caudate nucleus.
Association Study of a Functional Catechol-O-Methyltransferase Genetic Polymorphism with Age of Onset, Cognitive Function, Symptomatology and Prognosis in Chronic Schizophrenia
Authors: Tsai Shih-Jen , Hong Chen-Jee , Liao Ding-Lieh , Lai I-Ching , Liou Ying-Jay
Published: May 2004

The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. This study aimed to assess the relationship between a functional polymorphism (Val158Met) of the COMT gene and age of onset (AOO), symptomatology, global cognitive function and prognosis in patients with schizophrenia. The study enrolled 154 patients with schizophrenia from chronic wards. Results failed to show a significant association between the Val158Met polymorphism and the Brief Psychiatric Rating Scale scores, Mini-Mental State Examination scores, and Social and Occupational Functioning Assessment Scale scores, but COMT Val158Met heterozygotes had a later AOO than homozygous patients. However, by further expanding the number of patients to 228 patients, the differences in AOO among the three COMT genotypic groups was not significant. The COMT Val158Met polymorphism did not appear to significantly affect susceptibility, symptomatology, global cognitive function and prognosis in Chinese patients with schizophrenia, but the possible association with AOO merits further investigation.
Declarative Memory Impairments following a Military Combat Course: Parallel Neuropsychological and Biochemical Investigations
Authors: Piérard Christophe , Béracochéa Daniel , Pérès Michel , Jouanin Jean-Claude , Liscia Pierrette , Satabin Pascale , Martin Serge , Testylier Guy , Guézennec Charles Yannick , Beaumont Maurice
Published: May 2004

The aim of this study was to investigate the impact on several forms of memory and metabolism of a 5-day combat course including heavy and continuous physical activities and sleep deprivation. Mnemonic performance and biochemical parameters of 21 male soldiers were examined before and at the end of the course. Our results showed that short-term memory (memory span, visual memory, audiovisual association) and long-term memory were significantly impaired, whereas short-term spatial memory and planning tasks were spared. Parallel biochemical analysis showed an adaptation of energy metabolism. The observed decrease in glycaemia may be partly responsible for the long-term memory impairment, whereas the decreases in plasma cholinesterases and choline may be involved in the short-term memory deterioration. However, there are also many other reasons for the observed memory changes, one of them being chronic sleep deprivation.