bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Perilaku Hidup Bersih dan Sehat Melalui Edukasi Sikat Gigi di SDN Kawengan
Authors: Arsilia Kharisma Nur Sabila , Ardiyanti Lutfia , Durori Ahmad Dini Fajar , Afifudin M. Agus , Dzaki Rafif Eka Harya , Kurniawan Erick , Azmi Dayyan Tsabitul , Herianto
Published: March 2024

At SDN Kawengan, Kedewan District, Bojonegoro Regency, in August 2023 a socialization event was held. The aim of this socialization is to teach Kawengan Elementary School students how to brush their teeth properly and correctly as a form of concern for the health of their teeth and mouth. It will also teach children how important it is to keep their teeth and mouth healthy to avoid diseases such as cavities, gingivitis, gum infections, canker sores, and broken teeth. To maintain oral and dental health, you must brush your teeth twice a day, before bed and after breakfast. and you have to brush your teeth for 2 minutes longer to remove dirt stuck to your teeth, using a toothbrush with soft bristles and using the right toothpaste. Lectures, questions and answers, and direct practice are socialization techniques used in socialization. The results show that children better understand how to keep their teeth and mouth healthy and better understand the importance of caring for and maintaining their health.
Sosialisasi Sistem Pengarsipan Guna Meningkatkan Tata Kelola Administrasi di Kampung Yanggandur Merauke
Authors: Haris Umiyati , Kontu Fransin , Oja Hubertus
Published: March 2024

The document archiving system in the government hierarchy of a village is crucial in today's modern era. Archiving aims to organise documents in the village organisation system as a form of village identity. This service aims to increase community understanding of the importance of archive management in the village administration system. This service was carried out in Yanggandur Village, Sota District, Merauke Regency. The method used in this service is delivering material on the Village Administration Filing System delivered through lecture and presentation methods. The result of the socialisation in this service is a real positive impact on efficiency, transparency, and village community services in the archiving process in the village administration system. Document management is also better organised through this socialisation which then results in three things. Firstly, there is an increase in efficiency in document management. Second, Better Information Accessibility, where this archiving system has brought significant changes in terms of information accessibility. Third, there is a reduced risk of data loss.
Pelatihan Pengelolaan Arsip Digital Menuju Kampung Tertib Administrasi di Kampung Urumb Kabupaten Merauke
Authors: Irawan Andri , Agung Rachmat
Published: March 2024

Organizing village government administration digitally is a necessity. This is due to the increasingly widespread need for the availability of accurate and fast village development information. The aim to be achieved in this service activity is to carry out training for Urumb Village Officials in the context of utilizing digital archives for structuring village government administration. The method used is the transfer of knowledge through training and assistance in using Google Drive as a medium for archive management and information presentation for village government officials. The results of this activity are increasing knowledge and skills, as evidenced by changes in behavior on a scale of 76-100, namely the high category. This is also proven by the increase in participants' conceptual understanding and practice in managing documents digitally in Urumb Village, an average increase of 25%. It is hoped that the results of this activity can provide solutions to archival problems in Urumb Village, Merauke Regency to move towards an orderly administrative village.
Profile of Rectal Cancer Patients Undergoing Radiation Therapy in Dr. Hasan Sadikin General Hospital From 2016 Until 2021
Authors: Kurniadi Nathanael , Utama Marhendra Satria , Purnama Andriana
Published: March 2024

Background: Rectal cancer is a type of malignancy that occurs in the rectum. One of the many options of therapy for rectal cancer includes radiotherapy. This research was done to learn about the profile of rectal cancer patients undergoing radiation therapy at Dr. Hasan Sadikin General Hospital from 2016 until 2021. Methods:  A retrospective descriptive study that uses data obtained from patient’s medical records from Dr. Hasan Sadikin General Hospital from 2016 until 2021. The sampling technique used is total sampling from 109 data of rectal cancer patients who underwent radiation therapy in Dr. Hasan Sadikin from 2016 until 2021 Results: : From all 109 rectal cancer patients undergoing radiotherapy, the most often patients found have the age group of 40-49 years old (28.4%), females (50.5%), are mostly found from Priangan area (65.1%), have the chief complaint of a problem with defecating (51.3%), at stage III (36.7%), and have previously received operative management from their previous institutions (42.2%). The patients are mostly undergoing radiotherapy for curative indications (68.8%) and most have a waiting time of more than six weeks before obtaining radiotherapy (61.4%). Conclusions:  Cases of rectal cancer in radiotherapy patients in Dr. Hasan Sadikin General Hospital from the year 2016 to 2021 are seldom compared to other types of cancer and mostly occur in patients aged 40 to 49 years old. Most of the patients come for a curative reason and must wait for more than six weeks before obtaining radiation therapy. Further research may be performed to find the most effective method of giving curative radiotherapy as well as the time given in the hope of making radiotherapy planning more effective in the future.
Acute Myeloid Leukemia in a Three-Year-Old Girl Mimicking Chronic Myeloid Leukemia in Blast Crisis, Challenge in Diagnosis and Treatment in Limited-Resourced Health Care Facility: A Case Report
Authors: Predani Ni Luh Putu Diaswari , Gunawan Andre , Mustika Putu Pradnyanita , Tedja I Gusti Ayu Wiradari
Published: March 2024

Introduction: : Acute myeloid leukemia (AML) is the second most common hematologic cancer in childhood. Clinically, AML has similar symptoms to other types of leukemias, and diagnosis remains a challenge due to limited access to pediatric hemato-oncology diagnostic examination. This study aims to report AML in a 3-year-old girl who was first suspected of Chronic Myeloid Leukemia (CML) in blast crisis, using a combination of clinical-hematology parameters and conventional morphology examination in a limited-resourced healthcare facility. Case Presentation: A 3-year-old girl was referred from a rural Eastern Indonesia hospital with symptoms of prolonged fever, leucocytosis, severe anemia, and severe thrombocytopenia. In the previous hospital, the patient had a history of hyperleukocytosis and peripheral blood smear suspected of CML in blast crisis. A peripheral blood smear was repeated in our hospital and showed findings of Auer rod cells suggesting AML. Two bags of packed red cells and 2 thrombocyte concentrations were administered before referral for further diagnostic evaluation with bone marrow aspiration. Bone marrow aspiration revealed multiple nucleoli suggested for AML with FAB classification as M4 subtypes, and she received chemotherapy in a tertiary hospitalConclusions: With limited resources, suspicion based on persistent clinical symptoms, routine hematology tests, and peripheral blood smear examination are important to distinguish AML from CML in blast crisis. Understanding clinical hematology parameters and peripheral blood smears is the first step in AML diagnosis pathway and decision for further diagnostic referral. Supportive therapy and early recognition of oncologic emergency must be done before referral to a tertiary referral hospital.
Cerebral Tuberculomas Mimicking A Brain Tumor: Report of Two Cases
Authors: Gill Arwinder Singh , Firdaus Muhammad , Sugiarto Yosafat Kurniawan , Rayhani Farilaila , Andriani Rini , Faried Ahmad
Published: March 2024

Introduction : Cerebral tuberculoma, a seldom encountered and severe manifestation of tuberculosis (TB), arises from the dissemination of Mycobacterium tuberculosis through the bloodstream. Its symptoms and radiological characteristics lack specificity, often resulting in diagnostic errors. Management predominantly involves medical intervention, with the treatment duration for cerebral tuberculoma ranging from 6 to 36 months. In specific instances, surgical intervention may be advised. Case presentation: We reported two cases of cerebral tuberculoma occurring in patients who presented with seizures, with space-occupying lesions evident on magnetic resonance imaging of the brain. There were no symptoms of concurrent extra cranial TB. Surgery was performed on both of the cases and anti-TB treatment began as soon as the diagnosis was made with corticosteroid as adjuvant treatment. Conclusion: : A combination of clinical, radiological, and histopathological examination is needed to confirm the diagnosis and determine the appropriate therapy. If ICP is increased as a result of the lesion and medical therapy has failed, surgical excision is required.
Etkinlik Uygulama Sürecinde Ortaokul Matematik Öğretmenlerinin Sorunları Teşhis ve Müdahale Biçimlerinin Yapısı
Authors: Bozkurt Ali , Güzel Mehmet , Özmantar Mehmet
Published: March 2024

Bu çalışmada ortaokul matematik öğretmenlerinin etkinlik uygulama sürecinde karşılaştıkları sorunları teşhis ve müdahale biçimlerinin yapıları belirlenmeye çalışılmıştır. Araştırmanın verileri etkinlik tasarım ve uygulamaları çerçevesinde haftada 3 saat olmak üzere 14 hafta süren bir mesleki gelişim eğitimi sonunda toplanmıştır. Eğitimlere 13 ortaokul matematik öğretmeni katılmıştır. Eğitimlerin 12. haftasından sonra katılımcılara iki hafta süre verilerek sınıflarında bir etkinlik uygulamaları, uygulama sürecini video kaydına almaları ve uygulama sonrasında uygulamanın niteliğine dair bir rapor yazmaları istenmiştir. 14. hafta sonunda ise katılımcılarla eş zamanlı olarak bir görüşme yapılmıştır. Görüşmede etkinlik uygulama sürecinde herhangi bir sorunla karşılaşıp karşılaşmadıkları, sorunları nasıl teşhis ettikleri, müdahale biçimleri ve müdahalelerden elde ettikleri sonuçlar üzerinde durulmuştur. Görüşmelerde 5 öğretmen süreçte karşılaştığı sorunlardan bahsetmiştir. Bu öğretmenlerden üçünün dile getirdiği sorun video kayıtlarında da izlenebildiği için bu üç öğretmen çalışmanın katılımcılarını oluşturmuş ve bu öğretmenlerden elde edilen veriler analiz edilmiştir. Araştırmadan elde edilen bulgulara göre katılımcıların, karşılaştıkları sorunların kaynağından ziyade sorunu görünür kılan faktörlere odaklandıkları ve buna dönük müdahalelerde bulundukları görülmüştür. Bu sonuçlara dayalı olarak öğretmenlerin sorunları teşhis etmeleri, müdahaleleri ve müdahale sonuçlarına dair bir model çıkarılmıştır.
Integration of BIM and LCA: a system to predict and optimise embodied carbon for prefabricated buildings
Authors: Ge Song , Zhang Xuan , Zhang Xueqing
Published: March 2024

This paper presents the development of a system for automatically predicting and optimising embodied carbon of prefabricated buildings during the design phase. Building information modelling (BIM) is selected as the working environment from data input to results display, highly improving the automation level of carbon assessment. Besides, automatic carbon assessment for on-site installation is achieved by developing a component-oriented on-site emission factor database from a Chinese code. This system also supports optimising embodied carbon by providing various low-carbon alternatives from the perspectives of selecting construction materials, transportation modes, and installation methods. This system is applied to a ten-storey office building for demonstration. It is found that the system can accurately estimate and efficiently reduce the embodied carbon emissions of prefabricated buildings
ISOLASI DAN IDENTIFIKASI BAKTERI PENGHASIL ENZIM GELATINASE DI MUARA PANTAI LUBUK TUKKO TAPANULI TENGAH
Authors: Purba Gusmita Enda Lorenza , Rasyidah Rasyidah , Mayasari Ulfayani
Published: March 2024

Enzim gelatinase merupakan enzim yang berperan penting pada sektor industri pangan dan non pangan. Enzim gelatinase dapat bersumber dari hewan, tumbuhan dan mikro-organisme. Penelitian ini bertujuan untuk mengetahui apakah terdapat bakteri penghasil enzim gelatinase dan karakteristik yang dimiliki oleh bakteri penghasil enzim gelatinase yang ditemukan di muara Pantai Lubuk Tukko Tapanuli Tengah. Penelitian dilaksanakan pada bulan September hingga November 2021 di UPT Laboratorium Mikrobiologi Kesehatan Daerah Jl. Williem Iskandar, Medan. Penelitian ini dibagi atas beberapa tahapan yaitu isolasi dan inokulasi, uji gelatin, uji pewarnaan gram, dan uji biokimia. Isolasi bakteri ditemukan 15 isolat murni dan diketahui tujuh dari isolat murni merupakan bakteri penghasil enzim gelatinase dengan kode isolat SS141, SS144, SS241, SS342, SS353, SS361 dan SS363. Hasil yang didapatkan dikarakterisasi dengan pewarnaan gram dan uji biokimia dan didapatkan hasil 1 isolat bakteri jenis genus Micrococcus dengan kode SS361 dan isolat bakteri lainnya dengan jenis genus Bacillus.
HIV: optimizing treatment and monitoring beyond virologic suppression
Authors:   , Oomen Patrick George August
Published: March 2024

Background:

More than four decades ago, the world faced an unprecedented global health crisis with the emergence of the Human Immunodeficiency Virus (HIV) epidemic. The initial years were fraught with challenges and setbacks in HIV treatment. However, the landscape changed significantly with the introduction of combination antiretroviral therapy (cART), which has now become remarkably effective in suppressing HIV with minimal side effects. This progress has prompted a shift in focus towards optimizing treatment and monitoring beyond virologic suppression.

Optimizing Treatment and Monitoring of HIV:

Chapter 2 delves into the real-world effectiveness and tolerability of switching to doravirine-based ART. The findings indicate that doravirine-based triple therapy is a non-inferior, effective, and well-tolerated option for ART-experienced individuals.

In Chapter 3, the association between residual viremia and subsequent viral blips in virologically suppressed individuals is explored. Protease inhibitor-based regimens were found to be associated with higher odds of residual viremia.

Chapter 4 elaborates on the impact of different ART regimens on HIV-associated immune activation. Despite insufficient evidence to support the superiority of dual therapy over triple therapy, the study sheds light on the complex interplay between ART regimens and immune activation.

The neurocognitive effects of discontinuing efavirenz are investigated in Chapter 5, particularly focusing on reward processing. Discontinuation of efavirenz did not lead to significant alterations in reward processing in neurocognitive asymptomatic individuals with HIV.

Chapter 6 delves into response inhibition and potential neural mechanisms underlying cognitive improvement after discontinuing efavirenz. The study suggests that discontinuing efavirenz does not substantially affect response inhibition, providing reassurance regarding cognitive functions in individuals with HIV on efavirenz.

Optimizing Treatment and Monitoring of HIV-associated Co-morbidities:

Chapter 7 examines the association between prior Pneumocystis jirovecii pneumonia (PJP) and long-term pulmonary impairment. While past PJP was not independently associated with diffusion impairment, the study underscores the importance of smoking cessation in individuals with HIV.

In Chapter 8, concerns regarding the impact of past PJP on diffusion impairment are addressed. The study concludes that past PJP alone does not significantly affect diffusion impairment in optimally treated HIV.

Chapter 9 presents a quality improvement study aimed at enhancing guideline-adherent hepatitis B virus (HBV) care in people with HIV. The study identifies areas for improvement, such as HDV antibody screening and HBsAg monitoring.

Conclusion:

Chapter 10 discusses the main findings of the dissertation and presents future perspectives. It addresses knowledge gaps and recommends new research projects to further optimize HIV treatment and monitoring.
Metal-ligand cooperativity at nickel π-complexes for the stabilization of reactive intermediates and hydrogenation catalysis
Authors:   , Sansores Paredes María de Lourdes Guadalupe
Published: March 2024

As the chemical industry is one of the largest and most impactful industrial sectors, chemistry research plays a determining role in the transition towards a sustainable world. To this end, the 12 principles of Green Chemistry are an important guide in the design of new chemical processes, focusing on minimizing (or eliminating) the use and generation of hazardous substances. The “Catalysis vs. Stoichiometric” principle establishes the key role of catalysts, as using them in small amounts can accelerate a chemical reaction. Generally, catalytic processes occur in a selective manner, involving less resources and generating less waste.
In line with this principle, this thesis focuses on the development of the catalytic potential of nickel, an earth-abundant metal, bound to phosphorus-based organic ligands bearing an unsaturated C=X (X = C, O or N) moiety. Our approach involved two different lines. First, the diverse transformations of a crucial “nickelacyclobutane” reactive intermediate were investigated to better understand and control the selectivity of catalytic reactions. The obtained results show that nickel intermediates can undergo selective reactivity in processes traditionally done by expensive precious metals. Second, an unusual mechanism for H–H and C–H bond activation using an olefin-nickel complex was discovered, and its utility for catalytic hydrogenation was demonstrated. These results bring new insight into how metal complexes catalyze hydrogenation reactions and provides a basis for the development of a new family of sustainable catalysts.
Nutritional regulation of intestinal development, homeostasis and cancer
Authors:   , de Jong Judith Cornelia Wilhelmina
Published: March 2024

The intestine functions in the absorption of nutrients and provides a first line of host-defense against pathogens. Nutritional intake has a direct influence on the intestinal epithelial layer and the function and number of different epithelial cell types; stem cells, Paneth cells, goblet cells, and enterocytes, etc. In this thesis, we investigated the influence of different nutritional components on the intestinal epithelial layer. First of all, we showed that acetate aids in intestinal maturation in fetal intestinal organoids. We showed that acetate increased differentiation and stem cell number, thereby inducing intestinal maturation. This may imply that acetate supplementation may benefit preterm infants, preventing malnutrition and the development of intestinal inflammatory diseases. Secondly, we show that the nutrient sensor Farnesoid X Receptor (FXR) inhibits colon tumor organoid proliferation in an isoform dependent manner. In addition, activation of FXR by its ligand changed the organoid morphology towards a differentiated epithelium. Both inhibition of proliferation and induction of differentiation will limit tumor growth, and targeting FXR should therefore be further exploited as therapy for colorectal cancer. Lastly, we identify that cystine restriction increases proliferation and stem cells in the small intestine as well as the number of goblet cells in the colon in mice. These data are important in the light of the current trend towards veganism, in which the diet is very restricted in the amount of cystine. To conclude, understanding nutritional regulation of the intestinal epithelial layer under normal and diseased conditions is essential to explore future treatment and prevention options.
A Critical and Comparative Analysis of Delegation and Reliance by Company Directors under the South African Companies Act 71 of 2008
Authors: Cassim Rehana
Published: March 2024

Delegation by directors and reliance on third parties is an important practical issue. Directors unlawfully delegating their powers or relying on third parties could face serious consequences, such as liability for breach of fiduciary duties, or even disqualification from acting as directors. Uncertainty over when a director may appropriately delegate to or rely on others could foster an overcautious approach to managing the company’s affairs and impede the company’s decision-making processes. This article critically analyses the principles of directors’ delegation and reliance on third parties under the South African Companies Act 71 of 2008. It contends that these principles lack clarity and are ambiguous. It compares these principles to the equivalent provisions of the Revised Model Business Corporations Act 1984 of the United States of America and the Corporations Act 2001 of Australia and makes recommendations to clarify and improve the law relating to delegation and reliance by company directors.
Transfer Pricing Documentation Methods in Nigeria: A Critique of the Prime Plastichem Case Against International Best Practices
Authors: Olika Daniel
Published: March 2024

The quest to ensure that the tax planning activities of multinational enterprises operating in Nigeria do not erode the country's domestic tax base has led to the enactment and enforcement of the Transfer Pricing (TP) Regulations, 2018 in Nigeria. The TP Regulation provides for a comprehensive framework to ensure that the pricing of related party transactions is consistent with global best practices on TP. The enforcement of the TP Regulation in Nigeria was taken a step further in 2020 when the Tax Appeal Tribunal affirmed the imposition by the Federal Inland Revenue Service (FIRS) of liability of over one billion naira on Prime Plastichem Nigeria Limited for failing to apply consistent TP methods in the financial years 2013 and 2014. While this decision was hailed as Nigeria's first decision of the Tax Appeal Tribunal (TAT) dealing with transfer pricing, the decision has been criticised for failing to apply the global standards for TP documentation. This article seeks to critique the principles of TP documentation espoused in the Prime Plastichem case vis-à-vis international best practices on transfer pricing documentation.
Competition and Corruption: Sodalicia in Late Republican Rome
Authors: Karataș Sema
Published: March 2024

Roman Republican elections especially during the Late Republic were a ubiquitous phenomenon. The small number of higher magistracies in comparison to the growing number of eligible candidates often led to a fierce competition within the political elite. To secure a win, competitors running for office made use of a whole spectrum of methods which often overstepped the legal and moral boundaries and eventually resulted in legal measures. The lex Licinia de sodaliciis enacted in 55 BCE is one of these measures. This article studies the lex by raising questions about its historic background, its target – electoral misconduct by organising sodalicia that is political associations within the voting districts – the trials conducted under the law, the effect associations had on Roman politics, and the Senate’s effort to regulate them thorough legislation.
DETERMINING THE RELATIONSHIP BETWEEN ADULTS' NUTRITIONAL HABITS AND CONSTIPATION
Authors: Yılmaz Hacı Ömer , Özgür Mustafa
Published: March 2024

This study was planned and conducted to determine the relationship between dietary habits and constipation status of adults. The data of the study were obtained via an online questionnaire. The presence of less than three defecations per week was considered as constipation (+). The questionnaire form used to collect the study data included socio-demographic characteristics, eating habits, consumption status of food groups according to the International Physical Activity Form (Short Version) and national dietary guide recommendations. The study was conducted with 330 participants. The prevalence of constipation was determined as 28.8% among the participants in the study. Among those with constipation (+), 55.8% reported consuming two main meals per day and 50.5% reported skipping meals. The weekly walking activity of participants with constipation (+) was statistically lower than those with constipation (-) (p
PREDIKSI KEBANGKRUTAN MENGGUNAKAN METODE Z-SCORE DAN PENGARUHNYA TERHADAP HARGA SAHAM PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Ubaidillah Roykhan
Published: March 2024

Perusahaan manufaktur yang  terdaftar di Bursa Efek Indonesia tentunya tidak bisa lepas dari dampak krisis keuangan global pada tahun 2008. Stabilitas sistem  keuangan perusahaan manufaktur yang terdaftar pada Bursa Efek Indonesia sangat  rentan terhadap krisis  keuangan global, hal ini apabila tidak segera diantisipasi oleh manajemen akan mengakibatkan potensi kebangkrutan yang tinggi pada perusahaan  terkait. Penelitian ini bertujuan untuk menguji dan mengatahui bagaimana metode Z-Score Altman yang dikembangkan pada tahun 1984 mampu memprediksi  kebangkrutan  yang terjadi pada perusahaan manufaktur  yang  terdaftar di Bursa Efek Indonesia, serta mengetahui dan menguji pengaruh prediksi kebangkrutan tersebut terhadap harga saham pertusahaan terkait. Z-Score yang diterapkan dalam penelitian ini berhasil menggolongkan sampel perusahaan yang terdaftar di Bursa Efek Indonesia pada kategori tidak bangkrut, daerah rawan, dan tidak bangkrut. Uji hipotesis untuk mengetahui pengaruh terhadap harga saham dalam penelitian  ini menggunakan uji t, dimana hasil uji tersebut menyatakan bahwa ada pengaruh antara prediksi kebangkrutan menggunakan Z-Score terhadap harga saham perusahaan yang terdaftar di Bursa Efek Indonesia.
PENGARUH TINGKAT SUKU BUNGA KREDIT DAN CAPITAL ADEQUACY RATIO TERHADAP PROFITABILITAS ( RETURN ON ASSET) (Studi Pada Perusahaan Perbankan Yang Terdaftar di Bursa Efek Indonesia Periode 2011-2013)
Authors: MEDHA AYOE P. TYA  , Wiwiek Kusumaning Asmoro
Published: March 2024

The purpose of this research was to determine the effect of financial ratio analysis of the company's profitability in banking. This research is a hypothesis test, which examines the effect of variables that can affect profitability.

This research is a quantitative research using secondary data collection techniques, to conduct library research and documentation. The secondary data used in this research were obtained from the official website of the Indonesia Stock Exchange and Bank Indonesia's website. Companies sampled in this research amounted to 15, year of research period from 2011 to 2013, the sampling technique used was purposive sampling. The data used are annual financial statements. Data analysis techniques in this research using multiple regression, hypothesis testing method used is the coefficient of determination, simultaneous regression coefficient test, and test the partial regression coefficients.

The results of this research indicate that all information simultaneously Credit Interest Rateand the Capital Adequacy Ratio (CAR), effect on profitability. Partially loan interest rate has no effect on profitability, while the Capital Adequacy Ratio (CAR) that affect profitability.
PENGARUH LABA KREDIT DAN NON PERFORMING LOAN TERHADAP RETURN ON ASSETS (Studi Empiris Pada Perusahaan Pembiayaan Yang Terdaftar Di Bursa Efek Indonesia)
Authors: MUHAMMAD RAHARDYAN  , Dion Yanuarmawan
Published: March 2024

The purpose of this study was to examine effect of credit profit and non performing loans on profitability as measured by return on assets. Research object is a Registered Finance Company in Indonesia Stock Exchange from 2008 - 2012 This study used a descriptive quantitative method that consists of three variables: Income Loans and Non-Performing Loans as independent variables and ROA as the dependent variable. The type of data used is quantitative data and data sources used are secondary data. This data collection technique is the technique of documentation and literature study. Methods of data analysis used in this study is multiple regression analysis and tested by t-test.The test results showed that the levels of credit has a significant effect on profitability.

These results can be seen in the R Square of 0.522, which means the relationship between the profitability of credit has a very strong relationship. The results of this study confirmed the hypothesis testing results through the t test showed a significance level of 0.000 and credit profit 0,046 NPL, both are below 0.05, which means the level of income and credit NPL significant effect on profitability (ROA).
PENGARUH DENDA TERHADAP TINGKAT NON PERFORMING LOAN (STUDI KASUS PADA PT. BRI (PERSERO),Tbk CABANG KEDIRI TAHUN 2012-2014)
Authors: Sherly Ayu Aprylya
Published: March 2024

This research aims to know the influence of fines against the level of NPL. Fines in this study was divided into two fine daily and monthly fines as measured by nominal. NPL at this research is measured by a ratio. This research is the research hypothesis tests that test the influence of the variables that can affect the level of NPL.

This study uses secondary data collection techniques, by conducting studies, librarianship and documentation. Secondary data used in the study was obtained from the financial statements of PT BRI (Persero), Tbk branch of Kediri in 2012-2014. The sample in this research is one hundred clients with credit research period from 2012 to 2014, with a sampling technique used was purposive sampling. Technique of data analysis in this study using multiple linear regression, hypothesis testing method used is test the coefficient of determination , the keberartian test model, and the significance of the individual parameters.

Determination of coefficient of test results was 33.5%, which means that daily fines and fines affecting monthly NPL amounting to 33.5% and the rest IE 66,5% explained by causes other than the independent variable used in this research. The results of this research show that simultaneously daily fines and fines significantly influential monthly against the level of NPL. The influential daily fines partially significantly to the level of NPL, and significantly influential monthly fines against the level of NPL.
ANALISIS TINGKAT KEMANDIRIAN, EFEKTIFITAS DAN EFISIENSI TERHADAP PENDAPATAN ASLI DAERAH (PAD) PADA DINAS PENDAPATAN PENGELOLAAN KEUANGAN DAN ASET DAERAH (DPPKAD) DI PEMERINTAH KABUPATEN NGANJUK TAHUN 2011-2014
Authors: Uyik Retnaning Sayekti
Published: March 2024

Penelitian ini merupakan studi kasus untuk menganalisis tingkat kemandiriaan, efektifitas dan efisiensi terhadap Pendapatan Asli Daerah (PAD) pada Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah Tahun 2011-2014. Variabel yang digunakan dalam penelitian ini adalah variabel dependen yaitu Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah sedangkan variabel independennya yaitu Tingkat Kemandirian, Efektifitas dan Efisiensi Pendapatan Asli Daerah (PAD)

Jenis data yang digunakan adalah data Primer dengan menggunakan data laporan keuangan Tahun 2011-2014. Sampel yang digunakan dalam penelitian ini adalah Laporan Keuangan Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah dan populasi yang digunakan adalah seluruh Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah.

Dari hasil yang dilakukan diperoleh kesimpulan bahwa Tingkat Kemandirian, efektifitas dan efisiensi dari tahun ketahun menunjukkan tingkat yang fluktuatif, sehingga berbeda darii tahun ketahun.
Forma sonata na “Sinfonia em Sol menor” de Alberto Nepomuceno (1864–1920)
Authors: Dudeque Norton
Published: March 2024

O objetivo deste texto é examinar analiticamente a utilização da forma sonata por Alberto Nepomuceno na sua Sinfonia em Sol menor. Três dos quatro movimentos claramente utilizam a forma sonata como sua base estrutural que envolve não somente o esquema formal geral, mas também sua retórica interna. Para tal objetivo, utiliza-se uma abordagem analítica híbrida que aborda a forma sonata no seu aspecto geral por meio da teoria da sonata de Hepokoski e Darcy, seu detalhamento funcional-formal interno (teoria das funções formais de Caplin), e suas relações temático-motívicas (Grundgestalt e variação progressiva de Schoenberg). Além do aspecto analítico, se realiza uma contextualização de avaliações críticas desta obra de Nepomuceno, passando por críticas da época da estreia em 1897 até avaliações mais recentes.
Microelement strontium and human health: comprehensive analysis of the role in inflammation and non-communicable diseases (NCDs)
Authors: Ru Xin , Yang Lida , Shen Guohui , Wang Kunzhen , Xu Zihan , Bian Wenbo , Zhu Wenqi , Guo Yanzhi
Published: March 2024

Strontium (Sr), a trace element with a long history and a significant presence in the Earth’s crust, plays a critical yet often overlooked role in various biological processes affecting human health. This comprehensive review explores the multifaceted implications of Sr, especially in the context of non-communicable diseases (NCDs) such as cardiovascular diseases, osteoporosis, hypertension, and diabetes mellitus. Sr is predominantly acquired through diet and water and has shown promise as a clinical marker for calcium absorption studies. It contributes to the mitigation of several NCDs by inhibiting oxidative stress, showcasing antioxidant properties, and suppressing inflammatory cytokines. The review delves deep into the mechanisms through which Sr interacts with human physiology, emphasizing its uptake, metabolism, and potential to prevent chronic conditions. Despite its apparent benefits in managing bone fractures, hypertension, and diabetes, current research on Sr’s role in human health is not exhaustive. The review underscores the need for more comprehensive studies to solidify Sr’s beneficial associations and address the gaps in understanding Sr intake and its optimal levels for human health.
Case Report: Multiple types of arrhythmias in a late-confirmed Danon disease
Authors: Wang Nan , Cao Yu , Wang Jie , Zhang Qing
Published: March 2024

Introduction

Danon disease is an X-linked disorder caused by pathogenic variants in lysosome-associated membrane protein 2 (LAMP2) gene, typically characterized by the triad of hypertrophic cardiomyopathy, myopathy, and intellectual disability. However, many patients may not present the typical presentation, especially in the early stage. Electrocardiogram (ECG) abnormalities can be found in almost all patients, with Wolff–Parkinson–White (WPW) syndrome being the most common. We reported the case of a 51-year-old woman who experienced multiple types of arrhythmias over three decades and was diagnosed with Danon disease late by genetic testing.

Case summary

A 51-year-old woman with a 36-year history of intermittent palpitations was admitted due to hemodynamically stable ventricular tachycardia (VT). Her past medical history revealed multiple arrhythmias and ECG abnormalities in her 30s and 40s, including WPW syndrome with paroxysmal supraventricular tachycardia, paroxysmal atrial flutter, atrial fibrillation, ventricular tachycardia, and complete left bundle branch block. She denied any family history of cardiovascular disease or sudden death. Upon arrival, her vital signs were unremarkable. Cardiovascular magnetic resonance (CMR) imaging revealed left ventricular enlargement and late gadolinium enhancement (LGE) in the anterior, inferior, and lateral walls. Subsequent, whole-exome sequencing (WES) gene testing revealed a pathogenic heterozygous variant in LAMP2 gene (c.696T>A; p.Cys232Ter), which confirmed the diagnosis of Danon disease.

Conclusion

Genetic testing should be considered in patients who display multiple arrhythmias with LV structural abnormalities of unknown etiology for a possible Danon disease.
Exploring deep learning radiomics for classifying osteoporotic vertebral fractures in X-ray images
Authors: Zhang Jun , Xia Liang , Liu Jiayi , Niu Xiaoying , Tang Jun , Xia Jianguo , Liu Yongkang , Zhang Weixiao , Liang Zhipeng , Zhang Xueli , Tang Guangyu , Zhang Lin
Published: March 2024

Purpose

To develop and validate a deep learning radiomics (DLR) model that uses X-ray images to predict the classification of osteoporotic vertebral fractures (OVFs).

Material and methods

The study encompassed a cohort of 942 patients, involving examinations of 1076 vertebrae through X-ray, CT, and MRI across three distinct hospitals. The OVFs were categorized as class 0, 1, or 2 based on the Assessment System of Thoracolumbar Osteoporotic Fracture. The dataset was divided randomly into four distinct subsets: a training set comprising 712 samples, an internal validation set with 178 samples, an external validation set containing 111 samples, and a prospective validation set consisting of 75 samples. The ResNet-50 architectural model was used to implement deep transfer learning (DTL), undergoing -pre-training separately on the RadImageNet and ImageNet datasets. Features from DTL and radiomics were extracted and integrated using X-ray images. The optimal fusion feature model was identified through least absolute shrinkage and selection operator logistic regression. Evaluation of the predictive capabilities for OVFs classification involved eight machine learning models, assessed through receiver operating characteristic curves employing the “One-vs-Rest” strategy. The Delong test was applied to compare the predictive performance of the superior RadImageNet model against the ImageNet model.

Results

Following pre-training separately on RadImageNet and ImageNet datasets, feature selection and fusion yielded 17 and 12 fusion features, respectively. Logistic regression emerged as the optimal machine learning algorithm for both DLR models. Across the training set, internal validation set, external validation set, and prospective validation set, the macro-average Area Under the Curve (AUC) based on the RadImageNet dataset surpassed those based on the ImageNet dataset, with statistically significant differences observed (P<0.05). Utilizing the binary “One-vs-Rest” strategy, the model based on the RadImageNet dataset demonstrated superior efficacy in predicting Class 0, achieving an AUC of 0.969 and accuracy of 0.863. Predicting Class 1 yielded an AUC of 0.945 and accuracy of 0.875, while for Class 2, the AUC and accuracy were 0.809 and 0.692, respectively.

Conclusion

The DLR model, based on the RadImageNet dataset, outperformed the ImageNet model in predicting the classification of OVFs, with generalizability confirmed in the prospective validation set.
Bank digitalization and corporate green innovation: empowering or negative?
Authors: Jia Kaiwei , Zhang Yu
Published: March 2024

In the context of bank digitalization construction, this paper explores the impact and mechanism of bank digital transformation on corporate green innovation based on the data of listed enterprises from 2010 to 2021. It is found that bank digital transformation enhances the overall and strategic nature of corporate green innovation but has no significant impact on corporate substantive green innovation. The mechanism analysis shows that bank digital transformation can promote corporate green innovation by inhibiting corporate financialization and alleviating corporate financing constraints. Government environmental regulation and media attention have a positive moderating effect on the relationship between banks’ digital transformation, and enterprises’ green innovation, i.e., an increase in the level of government environmental regulation and an increase in media attention will strengthen the promotion effect of banks’ digital transformation on enterprises’ green innovation. Heterogeneity analysis shows that the promotion effect of banks’ digital transformation on corporate green innovation is more significant for state-owned enterprises, heavily polluted enterprises, large-scale enterprises, and enterprises in the eastern region. Therefore, the digital transformation of banks can “empower” the green innovation of enterprises, help the green development of enterprises, and lead the high-quality development of the economy. At the same time, the study’s results also show that the green development of enterprises should not be “superficial” but “substantial.”
Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production
Authors: Kuga Taiga , Chiba Asako , Murayama Goh , Hosomi Kosuke , Nakagawa Tomoya , Yahagi Yoshiyuki , Noto Daisuke , Kusaoi Makio , Kawano Fuminori , Yamaji Ken , Tamura Naoto , Miyake Sachiko
Published: March 2024

Enhanced interferon α (IFNα) production has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). We previously reported IFNα production by monocytes upon activation of the stimulator of IFN genes (STING) pathway was enhanced in patients with SLE. We investigated the mechanism of enhanced IFNα production in SLE monocytes. Monocytes enriched from the peripheral blood of SLE patients and healthy controls (HC) were stimulated with 2′3′-cyclic GAMP (2′3′-cGAMP), a ligand of STING. IFNα positive/negative cells were FACS-sorted for RNA-sequencing analysis. Gene expression in untreated and 2′3′-cGAMP-stimulated SLE and HC monocytes was quantified by real-time PCR. The effect of GATA binding protein 4 (GATA4) on IFNα production was investigated by overexpressing GATA4 in monocytic U937 cells by vector transfection. Chromatin immunoprecipitation was performed to identify GATA4 binding target genes in U937 cells stimulated with 2′3′-cGAMP. Differentially expressed gene analysis of cGAS-STING stimulated SLE and HC monocytes revealed the enrichment of gene sets related to cellular senescence in SLE. CDKN2A, a marker gene of cellular senescence, was upregulated in SLE monocytes at steady state, and its expression was further enhanced upon STING stimulation. GATA4 expression was upregulated in IFNα-positive SLE monocytes. Overexpression of GATA4 enhanced IFNα production in U937 cells. GATA4 bound to the enhancer region of IFIT family genes and promoted the expressions of IFIT1, IFIT2, and IFIT3, which promote type I IFN induction. SLE monocytes with accelerated cellular senescence produced high levels of IFNα related to GATA4 expression upon activation of the cGAS-STING pathway.
Salicin alleviates periodontitis via Tas2r143/gustducin signaling in fibroblasts
Authors: Zhang Zhiying , Zhou Zhiyan , Liu Jiaxin , Zheng Liwei , Peng Xian , Zhao Lei , Zheng Xin , Xu Xin
Published: March 2024

Introduction

Cells expressing taste signaling elements in non-gustatory tissues have been described as solitary chemosensory cells (SCCs) or tuft cells. These “taste-like” cells play a critical role in the maintenance of tissue homeostasis. Although the expression of SCC markers and taste signaling constituents has been identified in mouse gingivae, their role in periodontal homeostasis is still unclear.

Methods

Public RNA sequencing datasets were re-analyzed and further validated with RT-PCR/qRT-PCR and immunofluorescent staining to explore the expression of TAS2Rs and downstream signaling constituents in mouse gingival fibroblasts (MGFs). The specific action of salicin on MGFs via Tas2r143 was validated with RNA silence, heterologous expression of taste receptor/Gα-gustducin and calcium imaging. The anti-inflammatory effects of salicin against LPS-induced MGFs were investigated in cell cultures, and were further validated with a ligature-induced periodontitis mouse model using Ga-gustducin-null (Gnat3−/−) mice.

Results

The expression of Tas2r143, Gnat3, Plcb2, and TrpM5 was detected in MGFs. Moreover, salicin could activate Tas2r143, elicited taste signaling and thus inhibited LPS-induced chemokines expression (CXCL1, CXCL2, and CXCL5) in MGFs. Consistently, salicin-treatment inhibited periodontal bone loss, inflammatory/chemotactic factors expression, and neutrophil infiltration in periodontitis mice, while these effects were abolished in Gnat3−/− mice.

Discussion

Gingival fibroblasts play a critical role in the maintenance of periodontal homeostasis via “SCC-like” activity. Salicin can activate Tas2r143-mediated bitter taste signaling and thus alleviate periodontitis in mouse, indicating a promising approach to the resolution of periodontal inflammation via stimulating the “SCC-like” function of gingival fibroblasts.
Effects of general and spinal anesthesia on postoperative rehabilitation in older adults after lower limb surgery: a retrospective cohort study
Authors: Li Guifei , Ma Qingjing , Li Yizhen , Tan Furong , Li Xuan , Chen Jie
Published: March 2024

Objective

To investigate the effects of perioperative general anesthesia (GA) and spinal anesthesia (SA) on postoperative rehabilitation in elderly patients with lower limb surgery.

Methods

This retrospective propensity score-matched cohort study included patients aged 65 years or older who underwent lower limb surgery between January 1, 2020, and May 31, 2023. The GA and SA were selected at the request of the orthopedic surgeon, patient, and their family members. The main outcomes included the incidence of the patient’s inability to self-care at discharge, postoperative complications including pulmonary infection, thrombus of lower extremity veins, infection of incisional wound and delirium, length of hospital stay, and incidence of severe pain in the first 2 days postoperatively.

Results

In total, 697 patients met the inclusion criteria, and 456 were included in the final analysis after propensity score matching. In the GA and SA groups, 27 (11.84%) and 26 (11.40%) patients, respectively, could not care for themselves at discharge. The incidence rates did not differ between the groups (p = 0.884). In contrast, the incidence of postoperative complications (GA: 10.53% and SA: 4.39%; p = 0.013) and the length of hospital stay (GA: 16.92 ± 10.65 days and SA: 12.75 ± 9.15 days; p < 0.001) significantly differed between the groups.

Conclusion

The choice of anesthesia is independent of the loss of postoperative self-care ability in older patients (>65 years) and is not a key factor affecting postoperative rehabilitation after lower limb surgery. However, compared with GA, SA reduces the incidence of postoperative complications and a prolonged hospital stay. Thus, SA as the primary anesthetic method is a protective factor against a prolonged hospital stay.
Anaplasma, Bartonella, and Rickettsia infections in Daurian ground squirrels (Spermophilus dauricus), Hebei, China
Authors: Xue Jing , Chen Si-Si , Xu Ze-Yun , Wang Fang-Ni , Wang Jiangli , Diao Danhong , Du Luanying , Xie Guang-Cheng , Guo Wen-Ping
Published: March 2024

Rodents have been confirmed as hosts of various vector-borne zoonotic pathogens and are important for the maintenance of these microbes in nature. However, surveillance for zoonotic pathogens is limited for many wild rodent species in China, so our knowledge of pathogen ecology, genetic diversity, and the risk of cross-species transmission to humans is limited. In this study, 165 spleen samples of Daurian ground squirrels (Spermophilus dauricus) were collected from Weichang Manchu and the Mongolian Autonomous County of Hebei Province, China, and Rickettsia, Bartonella, and Anaplasma were identified by DNA detection using polymerase chain reaction (PCR). Sequence analysis identified eight bacterial pathogens: R. raoultii, R. sibirica, Candidatus R. longicornii, B. washoensis, B. grahamii, B. jaculi, A. capra, and Candidatus Anaplasma cinensis. Co-infection of B. grahamii and R. raoultii in one sample was observed. Our results demonstrated the genetic diversity of bacteria in Daurian ground squirrels and contributed to the distribution of these pathogens. Six species, A. capra, R. raoultii, R. sibirica, Candidatus R. longicornii, B. washoensis, and B. grahamii, are known to be pathogenic to humans, indicating a potential public health risk to the local human population, especially to herders who frequently have close contact with Daurian ground squirrels and are thus exposed to their ectoparasites.