bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgery for Cubital Tunnel Syndrome: A Comparative Study of Small Incision with Classic Anterior Nerve Transposition
Authors: Naseer Hassan  , Raza Hassan  , Muhammad Usman  , Mumtaz Ali  , Farooq Azam  , Momina Saleem
Published: May 2024

Objective:  To evaluate the clinical outcomes of ulnar neuropathy, and cubital tunnel syndrome (CuTS) surgery via a small incision with that of anterior transposition of the ulnar nerve.
Materials & Methods:  In this comparative cross-sectional study, 108 patients were recruited from the Neurosurgery Department of Qazi Hussain Ahmad Medical Complex, Nowshera. Two Groups were made. Group A patients undergo either ulnar nerve anterior transposition or simple decompression via a small skin incision, while Group B patients undergo ulnar nerve subcutaneous anterior transposition through a classic skin incision.
Results:  Totally 108 patients were enrolled. Males were 67 and females were 41 with a mean age of 45.6 ± 12.97 years. During follow-up visits, an increase in clinical outcome measures was noted, but no statistically significant difference was seen in both groups. Nevertheless, in comparison to the two groups, complications were more in group B, in terms of superficial infection, numbness of skin at the medial elbow, revision surgery, and painful scar.
Conclusion:  It is concluded that keeping in view the stability/anatomical position of the ulnar nerve to undergo either simple decompression or anterior transposition through small skin incision is effective and an excellent procedure as compared to classic incision procedure in treating patients suffering from cubital tunnel syndrome.
Stuttering As a Disability in Pakistan; Policies and Its Implementation
Authors: Aqsa Malik  , Romana Pervez  , Gul Nayab  , Nusrat Naseem  , Zaish Awan  , Aqeel Ahmed  , Shoukat Hayat  , Muhammad Ibrar
Published: May 2024

Objective:  Stuttering is a disorder of speech fluency not only includes academic and social consequences but also has emotional/behavioral outcomes. Stuttering leads to negative emotions and feelings i.e., low confidence, frustration, shame, embarrassment, poor self-image, and negative social identity. The present study was aimed at incorporating the definition of disability in Pakistan policy and determining the position of stuttering in it.
Materials and Methods:  The nature of the current study is qualitatively conducted on 10 Participants approached through convenient sapling and exploring their responses through Thematic analysis. Participants falling in this category were recruited into the study from SLPs, Lawyers, disability advocates, and CSPs as per inclusion criteria. Common masses were excluded from the study. A Self-Developed Questionnaire/structured interviews were conducted. Questions developed by the Lawshe method. The tool was validated through content validity by 10“experts”.
Results:  Thematic analysis was done and the findings of the study indicated an individual’s negative reaction towards association with any kind of disability and communication barriers are also the main source of not fitting disability as a definition. Results also showed that lack of assessment and screening tools are the main barrier, however, Visibility as per data in research publications also consider a barrier towards recognition of it.
Conclusion:  The study has practical implications regarding stuttering as a Disability in Pakistan.
Anterior Lumbosacral Myelomeningocele Presenting as an Abdominal Mass
Authors: Ali Mumtaz , Ullah Akram , Hussain Ramzan , Khan Sajid , Ur Rahman Hanif , Saqib Summayah , Ali Amjad , Sahibzada Abdul Haseeb
Published: May 2024

Myelomeningocele is a complex pathology associated with variable clinical presentations and associated anomalies. Myelomeningocele presenting as an abdominal mass is extremely rare. This case report presents such a complex case of anterior lumbosacral myelomeningocele with clinical presentation of abdominal mass along with its surgical management. A 5-month-old boy was referred to the neurosurgery department, presenting with a congenital lump on his lower back along with abdominal mass, constipation, and urogenital dysfunction. An anterior Approach exploratory laparotomy was performed by a left lower abdomen oblique incision to excise the myelomeningocele. This case report illustrates that anterior lumbosacral myelomeningocele can present, in rare cases as abdominal mass along with urogenital dysfunctions and constipation and is managed with a collaborative effort from a multidisciplinary approach including urologists, neurosurgeons, and general surgeons
Incidence and Outcomes of Diastematomyelia in Spina Bifida Patients
Authors: Sagheer Ahmed  , Iram Bokhari  , Tanveer Ahmed  , Rabail Akbar  , Raheel Gohar
Published: May 2024

Objective:  To determine the prevalence of diastematomyelia in spina bifida patients and to assess the efficacy of surgical intervention.
Material and Methods:  This prospective research study was conducted at the Jinnah Postgraduate Medical Center in Karachi in the Neurosurgery department. We included 55 patients after fulfilling the inclusion criteria. All of the patients had craniospinal MRI, and the results, as well as any anomalies discovered, were noted for future reference during their therapy. Patients suffering from these diseases were treated surgically, which included sac excision and repair, cord detethering, and ventriculoperitoneal shunting. Throughout the postoperative period, all of these patients' outcomes were documented and assessed.
Results:  The majority of patients were under 1 month old (29 patients, 53.70%), whereas 13 patients were between one month and 1 year old. The patients were 2.8 years old on average. There were 23 males (42.60%) and 32 females (58.18%). Dermal sinuses, hypertrichosis, and skin dimples (signs of spina bifida occulta), with prevalence rates of 5.55 percent, 3.70 percent, and 1.85 percent, respectively. Spina bifida occulta was less frequent (17 cases) than spina bifida aperta (37 occurrences). 33 patients (61.11%) have myelomeningocele, followed by meningocele in three (5.5%), lipomyelomeningocele in six (10.9%), diastematomyelia in six (10.9%), dermal sinus in two (3.70%), along with spinal lipoma in one (1.85%) instance.
Conclusion:  The overall prevalence of Diastematomyelia in patients with spinal dysraphism is low. However vigilant assessment and management is crucial for optimal surgical benefit.
Keywords:  Diastematomyelia, Spina Bifida, Spinal Dysraphism.
The Lower-Back Painkiller Challenge: Efficacy of Tramadol Versus Tapentadol
Authors: Naveed Gul  , Kashif Ramooz  , Yasir Shehzad  , Soban Sarwar Gondal  , Fraz Mehmood  , Hafiz Muhammad Ali Khan  , Eesha Yaqoob  , Saad Javed
Published: May 2024

Introduction:  To reduce pain levels in people with lower back pain, the study looked at the comparative efficacy and tolerability of Tramadol and Tapentadol taken by oral route.
Materials & Methods:  This comparative study consisted of a total of 126 patients divided into 2 groups, the Tapentadol and Tramadol groups for managing low back pain. Participants aged 18-60 with moderate or higher pain intensity were included. Data on pain intensity, adverse events, and patient-reported outcomes were collected at baseline, day 7, and day 14. Participants were randomly assigned to Tapentadol or Tramadol groups, receiving respective medications for 14 days. Data analysis involved t t-test to compare groups. Means and SD were also calculated.
Results:  The mean age of the patients in the Tramadol group was 33.1 ± 19.1 and in the Tapentadol group was 37.6 ± 19.9, respectively. Sixty of the total participants were men and sixty-five were women. Participants were split equally between groups A and B, with 30 men and 33 women in group A and 30 men and 32 women in group B. The findings demonstrated that both medications considerably lessened moderate to severe chronic lower back pain (CLBP) patients' pain levels. At 28 days after the baseline, the mean VAS scores for groups A and B were 34.57 and 37.55, respectively. 
Conclusion:  According to the study's findings, these two medications effectively reduce pain in those with chronic lower back pain. Tapentadol is observed to be tolerated well and more effective than Tramadol.
The Text Neck Epidemic: Unveiling the Hidden Burden of Neck Pain among Medical Students
Authors: Yasir Shahzad  , Fraz Mehmood  , Soban Sarwar  , Kashif Ramooz  , Nadeem Akhtar  , Arslan Akram  , Eesha Yaqoob  , Saad Javed
Published: May 2024

Objective:  Text neck syndrome, caused by prolonged mobile device use, is increasingly common, especially among teenagers. Neck pain is a significant public health issue, affecting 40% of the population. Little research has focused on musculoskeletal pain in children and adolescents, including medical students. A cross-sectional study is needed to investigate text neck syndrome among medical students and provide effective prevention and treatment strategies.
Materials & Methods:  This cross-sectional study (n=508) utilized an online self-designed questionnaire incorporating the Neck Disability Index and the Nordic Musculoskeletal questionnaire. Descriptive and inferential statistics, including chi-square tests and p-value calculations using SPSS version 25, were employed. The study aimed to examine neck pain prevalence and consequences to inform interventions for improved health outcomes.
Results:  Among the 508 participants, 69.4% reported past neck pain. Females, those with higher stress levels, individuals using laptops/tablets for four or more hours, and medical students studying for 4 to 6 hours daily had higher neck pain prevalence (52.0%, 88.2%, 61.9%, and 57.5% respectively). Prevalence remained consistent between pre-clinical and clinical-year medical students. Multivariate analysis revealed a significant association between neck pain and longer mobile phone use, extended study hours, and lack of exercise. Only 16% sought treatment from a chiropractor/physiotherapist for their neck pain.Conclusion:  The study emphasizes the importance of better education on neck pain prevention and seeking professional help. Adding exercise to daily routines can also be extremely helpful in preventing neck pain. To fully understand the effect on medical students and develop effective interventions
Frequency of Ventilator-Associated Pneumonia among ICU Admitted Patients with Early Versus Delayed Tracheostomy
Authors: Sidrah Batool  , Muhammad Hassan Raza  , Wajiha Haq  , , Vandana Kafle  , Anjana Kafle  , Anjana Kafle
Published: May 2024

Objective:  Patients on mechanical ventilation in the intensive care unit (ICU) frequently develop ventilator-associated pneumonia (VAP), an acquired lung infection. The incidence of VAP varies highly in different setups. This study aimed to determine the incidence of VAP in the surgical ICU and the associated costs.
Materials & Methods:  An observational cross-sectional study was conducted and included 116 patients who had a tracheostomy in the surgical ICU of Lahore General Hospital. They were observed for the occurrence of VAP, mortality, ICU stay in days, and cost of the ICU stay. Tracheostomies done before 7 days from mechanical ventilation with the expectation of needing extended ventilatory support were classified as early tracheostomies (Group E), whereas those performed after 7 days owing to failure to wean were classified as late tracheostomies (Group L).
Results:  Patients in the early tracheostomy group had a mean age of 45.16 years, while those in the late tracheostomy group had a mean age of 50.00 years. Compared to the early tracheostomy group, the late tracheostomy group had a greater incidence of VAP, 8(25.8%) and 24(53.33%), and mortality, 8(25.8%) and 22(48.88%), respectively. Mean values like pre-tracheostomy ventilation were 4.70 & 12.17 days, ICU stay was 9.54 & 16.64 days and total cost in PKR was 796774.19 & 1438888, respectively among early tracheostomy & late tracheostomy groups. 
Conclusion:  The occurrence of VAP and mortality is significantly lower in patients who have undergone early tracheostomy.
Text Neck Syndrome among Undergraduate Students in Lahore, Pakistan
Authors: Syed Ali Zunair  , Babar Butt  , Farhan Fateh Jang  , Amna Malik  , Nasir Raza Awan
Published: May 2024

Objective:  To evaluate the frequency, severity, and prevalence of Text Neck Syndrome among undergraduate students using mobiles, tablets, or laptops.
Material and Methods:  The descriptive study was conducted in two private colleges in Lahore after approval from the institutional review board of Sharif Medical and Dental College, Lahore, Pakistan. Students with ages greater than 16 years who used mobile phones daily for more than 1 hour were enrolled. Baseline demographic information was collected and questions regarding the duration of phone usage and neck pain were asked. Calculated a sample size of 266 with the help of the WINPEPI statistical program with a confidence of 95% and acceptance difference of 0.06 with an assumed proportion of 0.46.
Results:  The age range was 18 – 23 years. Out of 266 undergraduate students, 122 (46%) were male and 144 (54%) were female. 157 (59%) students reported having neck pain: Mild in 88 (56.1%), Moderate in 55 (35%), and Severe in 14 (8.9%) students according to self-perception. 97 (61.8%) students were intermittent, 35 (22.3%) had continuous, and 25 (15.9%) had debilitating neck pain.
Conclusion:  According to this study, Text Neck Syndrome was common in undergraduate students using smartphones, tablets, or laptops.
Prevalence and Impact of Hyponatremia on Hospital Stay in Subarachnoid Hemorrhage Patients
Authors: Zeeshan Ullah  , Ihtisham Ullah  , Imad Majeed  , Muhammad Fawad Khan  , Saad Ali  , Hina Nawaz  , Asim Ali Shah
Published: May 2024

Introduction:  This research study was designed to ascertain the prevalence of hyponatremia and its impact on the duration of hospital stay in patients with subarachnoid hemorrhage (SAH) in our local population.
Materials & Methods:   We carried out this study at the Department of Neurology, Lady Reading Hospital Peshawar for 1 year, which started in March 2022. The total sample size was 90 and a consecutive sampling method was used for sampling the study population. Patients aged between 20 to 70 years and who had a diagnosis of SAH were involved in included in the study, while those with confounding conditions were put in the exclusion criteria.
Results:  Our study showed a high prevalence of hyponatremia (42%) in patients with SAH, and it was associated with a prolonged duration of hospital stays of 8.2 days (SD±3.5). There was a statistical difference in the mean hospital stay between the patients with hyponatremia and those without hyponatremia (t=3.2, p<0.002).
Conclusion:  Our study reported a high prevalence of hyponatremia in SAH patients and has established an association with longer hospital stays. Thus, identifying and managing patients of hyponatremia with SAH promptly should be emphasized for better results and to lessen the financial burden on families and the hospital.
Demographic Profiling of Patients on Drug Dependence Admitted in Punjab Institute of Mental Health, Addiction Treatment Centre, Lahore
Authors: Farakh Abdullah  , Aqila Unbrin  , Muhammad Ahmad Faisal  , Tahira Arshad
Published: May 2024

Objective:  Drug dependence is a global public health concern, affecting millions and contributing to widespread negative consequences. This research delves into the demographic characteristics of drug abuse patients at the Punjab Institute of Mental Health (PIMH) Addiction Treatment Center in Lahore, Pakistan.
Materials and Methods:  Utilizing a cross-sectional research-based descriptive design, the study employs purposive sampling and a comprehensive questionnaire to collect data from 100 drug abusers. The analysis considered age, gender, socioeconomic status, residential area, occupation, education, marital status, and family system, shedding light on the diverse factors contributing to the drug dependence of the patients.
Results:  The results revealed a diverse age range (18-80 years) among participants (M=33,4, SD=10.3), most of them belonging to lower (34%) and middle class (39%); 67 respondents residing in the urban region and 32 from the rural areas. Heroin (32.3%) was reported to be the most consumed substance while cannabis (25.8%) and crystal methamphetamine (16.4%) were the second and third respectively taken mostly through sniffing. Among the reasons for using drugs, peer pressure came out to be the most reported cause.
Conclusion:  The findings underscored the complexity of drug dependence, necessitating targeted interventions that consider demographic variations that are crucial for effective treatment and prevention strategies. The study contributed valuable knowledge to the existing scientific understanding of drug dependence, paving the way for more informed public health initiatives.
Outcome of Dual Stability and Decompression through Single Posterior Approach in Tuberculosis of Dorsolumbar Spine
Authors: Waqar Ahmed  , Khizer Ghalib  , Adeel Hamid  , Muhammad Shakeel  , Muhammad Qasim  , Muhammad Khalid Syed et al.
Published: May 2024

Objective:  To evaluate the outcome of dual stability and decompression through a single posterior approach in patients with tuberculosis of the dorsolumbar spine in terms of Oswestry Disability Index and Frankel Neurological Grading.
Material and Methods:  It was a prospective cohort study involving 34 patients with tuberculosis of the dorsolumbar spine who underwent dual stability and decompression through a single posterior approach. Follow-ups were done at 2nd, 6th, 12th and 16th weeks. The outcome was assessed using the Oswestry Disability Index and Frankel Neurological Grading.
Results:  In 34 patients, the mean age was 36.59±13.51 years. There were 20 (58.8%) males and 14 (41.2%) females. There were 9 (26.5%) patients who had dorsal spine tuberculosis, while lumbar spine TB and dorso-lumbar spine TB were diagnosed in 13 (38.2%) and 12 (35.3%) patients respectively. The mean surgery time was 4.20±0.66 hours. According to the Oswestry Disability Index, before surgery, 2 (5.9%) patients had minimal disability while after 16 weeks of follow-ups, these numbers increased to 23 (67.7%) showing statistically significant improvements. According to Frankel Neurological Grading, before surgery, 3 (8.8%) patients had normal function while after 20 weeks of follow-up following surgery, 20 (58.9%) had normal functions.
Conclusion:  Dual stability and decompression through a single posterior approach were found to have good functional and fusion outcomes according to the Oswestry Disability Index and Frankel Neurological grading.
Perfil sociodemográfico da Tuberculose nos municípios do Rio Grande Do Sul no período de 2018 a 2022
Authors: Carraro Caroline , Cavalcanti de Morais Juliana , Lima de Castro Maria Luiza , Lira Milhomem Emanuela
Published: May 2024

Introdução: A tuberculose é uma doença infectocontagiosa crônica grave que afeta principalmente os pulmões. Objetivo: Descrever o perfil sociodemográfico da tuberculose nos municípios do Rio Grande do Sul em um período de cinco anos. Metodologia: Foram coletados dados do Sistema de Informação de Agravos de Notificação (SINAN), na plataforma do Banco de Dados Digitais do SUS (DATASUS) entre 2018 e 2022.  Resultados: Perfil predominantemente masculino, jovem, de pele branca, com baixa escolaridade, apresentando uma predominância de casos novos no tipo de entrada, a forma pulmonar da doença, desfecho favorável, na maioria dos casos o tratamento diretamente observado não foi realizado e houve uma dominância de casos negativos para coinfecção tuberculose/HIV. Conclusão: Percebe-se a importância deste estudo para compreender de modo mais eficaz o perfil da tuberculose nestes municípios, a fim de contribuir para iniciativas de prevenção e melhores prognósticos.
COMPARAÇÃO DA EFICÁCIA DO CLAREAMENTO DENTAL COM GÉIS DE PERÓXIDO DE HIDROGÊNIO EM DIFERENTES CONCENTRAÇÕES: REVISÃO DE LITERATURA INTEGRATIVA
Authors: Do Nascimento Silva Mariana , Roeder Maria Vitória Paz , Diniz Ana Carolina Soares
Published: May 2024

INTRODUÇÃO: O clareamento dental promove resultados satisfatórios de maneira conservadora, segura e eficaz em curto intervalo de tempo por meio da utilização de agentes clareadores. A concentração dos géis clareadores deve ser escolhida de forma cuidadosa a fim de evitar a sensibilidade dentária, alcançar a estética desejada e melhorar a qualidade de vida. OBJETIVO: Comparar a eficácia entre os géis clareadores de peróxido de hidrogênio em diferentes concentrações na longevidade do tratamento clareador, riso de sensibilidade dental e impacto na qualidade de vida dos pacientes. METODOLOGIA: Foram utilizados 06 artigos selecionados das bases de dados PubMed e SciELO. Os critérios para inclusão foram estudos clínicos randomizados ou não-randomizados que respondessem à pergunta norteadora “Qual a concentração do gel clareador promove resultados com maior longevidade clareadora, menor sensibilidade dental e melhoria na qualidade de vida dos pacientes?” publicados entre os anos de 2014 e 2019. Os critérios de exclusão foram revisões de literatura e casos clínicos. RESULTADOS: A análise dos resultados evidenciou que não há diferença na eficácia do clareamento dental de acordo com a concentração dos géis clareadores. Entretanto, o clareamento dental pode influenciar, relativamente, na percepção estética e qualidade de vida de cada paciente. CONCLUSÃO: O gel clareador de peróxido de hidrogênio, tanto em baixa quanto em alta concentração é eficaz e promove uma melhor qualidade de vida a longo prazo. A escolha entre as concentrações deve considerar as necessidades e características individuais de cada paciente.
DEMÊNCIA E TRANSTORNOS COGNITIVOS EM IDOSOS
Authors: Haonat George Antonios Ferreira Issa , Rezende Lívia Aguiar de , Paiva Luís Flávio de Amorim , Miranda Larissa Abussafi , Rubião Arthur Lennon Nascimento , Castro Bruno Bessa Macedo de , Nogueira Lázaro Henrique Furtado , Teixeira Bruno Gurgel , Lima João Marcos Prates , Feital Victhoria Emanuelle , Oliveira Nathan Barros De , Medicina Rafael Siqueira de Carvalho , Marily Sarah Santos Azeredo , Nunes Hiago Teles Siqueira , Azevedo Maria Eduarda Cunha de , Nicoli Higor Fontana
Published: May 2024

O presente estudo tem por objetivo conhecer sobre as características de transtornos cognitivos e demências na clínica privada de especialistas e o preparo desses médicos nessa área. A demência é uma das principais causas de morbimortalidade entre os idosos, definida como uma síndrome crônica caracterizada por prejuízo progressivo da cognição envolvendo um ou mais domínios, como memória, aprendizado, linguagem, funções executivas, habilidades visuoespaciais e comportamento, além de incapacidade e prejuízo no desenvolvimento psicossocial. O presente trabalho evidenciou alta prevalência de déficit cognitivo e que foi associada à idade, escolaridade, capacidade funcional e estado nutricional. É possível questionar se isso se deve à grande quantidade de pessoas com comprometimento cognitivo leve sem demência com remissão posterior dos sintomas, ou pela ocorrência de demência de início precoce.
Mama
Authors: Mpedi Letlhokwa George
Published: May 2024

Mother’s Day is an annual occasion when we take the time to honour the incredible women who have shaped our lives through their love, support, and guidance. In celebration of Mother’s Day 2024, the University of Johannesburg (UJ) published Mama. This is a unique anthology that pays tribute to the strong mother figures who have left an indelible mark on our hearts and minds, showcasing their unwavering strength, resilience, and love. As NK Jemisin writes in her novel The Hundred Thousand Kingdoms, “In a child’s eyes, a mother is a goddess. She can be glorious or terrible, benevolent or filled with wrath, but she commands love either way. I am convinced that this is the greatest power in the universe.” By sharing these stories, we hope to celebrate the strength, resilience, and love embodied by mothers and mother figures everywhere. Through this anthology, we aim to foster a deeper appreciation for the women who have shaped our lives and to provide a platform for the UJ community to reflect on the profound impact of maternal figures.
Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value.
Authors: Alfian Muhammad
Published: May 2024

Abstract
Turmeric and tamarind herbal medicine is one of the drinks with turmeric and tamarind as raw materials which is quite widely consumed by the community, either in liquid form or in powder form. Jamu turmeric acid can be used to prevent the negative effects of free radicals on the body because there are active antioxidant compounds, besides that it can be used as a natural antioxidant. There are many natural antioxidants in nature, one of which is in traditional medicine. The content of Jamu turmeric acid is curcuminoids where this compound is useful as an anti-inflammatory and antioxidant. This study aims to determine the antioxidant activity of instant turmeric powder drink produced by of UMKM Healthy Partners, Kiringan Bantul herbal tourism village, using the DPPH method (2,2-diphenyl-1-picrylhydrazyl). The absorbance measurement to determine the antioxidant activity of each sample of turmeric tamarind powder was tested using a UV-Vis spectrophotometer at a maximum wavelength of 516 nm. Determination of antioxidant activity by the DPPH method is expressed by the IC50 (Inhibiton Concentration 50) value. The results showed that the antioxidant activity of the instant turmeric powder drink (Curcuma domestica val.-tamarindus indica l.) produced by Mitra Sehat SME in the Jamu Kiringan Tourism Village, Bantul, was included in the very weak category with an IC50 value of each sample successively. The participants were sample A of (276.005 ppm), sample B of (265.434 ppm), and sample C of (256.183 ppm).
Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value.
UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN SIRIH CINA (Peperomia pellucida) TERHADAP PENYEMBUHAN LUKA EKSISI PADA TIKUS PUTIH (Rattus norvegicus)
Authors: Sari Rika Puspita
Published: May 2024

ABSTRAK
Wahyuni. Test the effectiveness of Chinese betel leaf ethanol extract ointment on excision wound healing in white rats (Supervised by: apt.Rika Puspita Sari, S.farm.,M.Si )
 
Wounds are physical injuries that can cause tears and damage to skin tissue. One type of the wound is an excision wound. An excision of wound caused by the cutting of tissue by a sharp object. The main goal in wound management is to achieve rapid healing with optimal fuction and good result. That  can be achieved by preventing infection and trauma by providing an environtment that optimizes wound healing. One of the plants that have the potential to heal wounds is the Chinese betel plant that have the potential to heal wounds is the Chinese betel plant the purpose of the research  to determine the effectiveness of giving Chinese betel leaf extract on excision wound healing in white rats(rattus norvegicus). The research was conducted in the laboratory of health the husada deli tua.
The method of the research conducted out experimentally, the sample was extracted by the maceration method. And then the extract was formulated into ointment availability with concentrations of 2%,4%, and 8% furthermore, on evaluation of the availability of the ointment was carried out, by organoleptic test, homogeneity test, pH test and spreadability test.
The result of the research for each group gave the best treatment experienced a decrease in the diameter of the cut wound was the positive control group (povidone iodine) and 8% concentration. Conclusions: the ethanol extract of chial betel leaf has the effectiveness of healing excision wounds at a concentration of 8%
Keywords: Chinese betel leaf extract, excision wound
PENETAPAN KADAR VITAMIN C DAN FORMULASI SEDIAAN GRANUL INSTAN EKSTRAK KULIT JERUK KEPROK (Citrus reticulate Blanco.)
Authors: Sriarumtias Framesti Frisma , Rizkio Syamsudin Raden Aldizal Mahendra
Published: May 2024

Tangerines (Citrus reticulata Blanco.) is one of the national superior types of oranges that contain lots of vitamin C. Vitamin C is the simplest vitamin and has an important role on the human body. So far the use of arrowroot is only on the fruit, while the peel is only a waste. The purpose of this study is to utilize tangerine peels into preparations that have a use value for the community, in the form of instant granules. The method used in the extraction of tangerine peel is maceration by making granules using the wet granulation method, and determination of vitamin C levels by quantitative methods, UV-Vis spectrophotometry method. After obtaining the vitamin C levels, then formulations are made in the form of instant granules and quality evaluations are carried out. The results showed that vitamin C content was 130 mg / 1250 mg extract and the formula was made with the best formula, Formula 1.
Pengaruh Metode Pengeringan Ekstrak Daun Kelor (Moringa oleifera Lam) Terhadap Aktivitas Antioksidan
Authors: Pertiwi Adinda Putri
Published: May 2024

Daun kelor adalah salah satu tumbuhan yang sudah dimanfaatkan masyarakat dalam pengobatan tradisional. Tumbuhan kelor banyak mengandung berbagai molekul penghambat radikal bebas, seperti aktivitas antioksidan. Pembuatan simplisia daun kelor dilakukan dengan pengeringan menggunakan oven pada suhu 400C dan sinar matahari langsung. Simplisia yang terbentuk dimaserasi dalam pelarut etanol 70%. Pengukuran aktivitas antioksidan ekstrak menggunakan metode DPPH dengan Spektrofotometer UV-Vis pada panjang gelombang 516,50 nm. Hasil penelitian memperlihatkan bahwa daun kelor yang dikeringkan dengan oven pada suhu 40°C memiliki aktivitas antioksidan nilai IC50 67,75 ppm dengan kategori antioksidan kuat dan ikeringkan di bawah sinar matahari memiliki nilai IC50 122,34 ppm dengan kategori antioksidan sedang. Dari penelitian ini adalah aktivitas antioksidan ekstrak daun kelor dengan metode pengeringan oven lebih tinggi dari metode pengeringan sinar matahari langsung.
UJI STABILITAS FISIK FORMULASI SEDIAAN HAIR TONIC HERBAL BUAH MENTIMUN (Cucumis Sativus L) SEBAGAI PERAWATAN RAMBUT
Authors: Musthika Komang Tri , Dewi Putu Indra Cyntia
Published: May 2024

Hair is an essential part of the body that often experiences various problems, one of which is hair loss. Fortunately, hair loss problems can be prevented by applying a hair tonic. Many hair tonic preparations are on the market, both made from herbal and synthetic ingredients. Efforts have been made to formulate cucumber into hair tonics. This study aims to utilize herbal plants, particularly cucumber, as a remedy for hair loss. Cucumber was developed into several hair tonic formulations, and their physical stability was subsequently tested. The cucumber was extracted using the infusion method. The yielded infusion was later made into three formulas of hair tonics with three times replications for each procedure. Following the formulations, physical stability tests of the preparations were carried out, such as organoleptic, homogeneity, pH, and viscosity tests. Results of the tests showed that the trials were physically stable with a homogenous physical appearance indicating an even distribution of cucumber extract in the preparations. Further results showed average pH of 5.87, 6.12, and 6.49 with viscosity values of 0.0082, 0.0083, and 0.0085 N.S/m2, respectively. In conclusion, all the ingredients in the formulation of herbal hair tonics provided stable color and pH range that still met the requirements. Hence, this study suggested the administration of cucumber hair tonic as one of many remedies for hair ailments, specifically hair loss.
ANALISIS NILAI SPF PADA PRODUK TABIR SURYA MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS
Authors: Yuliati Ninis , Agustini Silvia Putri , Pujiono Fery Eko , Mulyati Tri Ana
Published: May 2024

Indonesia is a country with high sun exposure and the potential for high sun exposure. These rays are UVA (290-320) and UVB (320-400) rays which have both good and bad effects on humans. The formation of Vitamin D and provitamin D is a benefit, but with severe ozone depletion the UV rays produced can be harmful to human health and can cause cancer. Sunscreen which is used to protect the health of human skin from the negative effects of solar radiation and can absorb light exposure is often used in daily life as a cosmetic whose effectiveness in light absorption is based on the value of the sun protection factor (SPF), hereby to determine the value and category SPF value on sunscreen products with UV-Vis Spectrophotometry method to find out its effectiveness. By using the sampling method of Non Probability Sampling. In the determination, mixing 3 samples of sunscreen, the determination of this SPF value is a measure of the protection of sunscreen cream preparations against Ultraviolet rays. The higher the SPF value, the greater the protective effect against sunburn. The results obtained deviation of 1.04 with an average SPF in this study was 4.1 which was included in the SPF category with  minimal protection.
SYSTEMATIC REVIEW : UJI AKTIVITAS ANTI BAKTERI EKSTRAK BUAH ANDALIMAN (ZANTHOXYLUM sp)
Authors: Batubara Amirah Nahdiah , Batubara Saiful , Simanjuntak Afrilius
Published: May 2024

One type of spice whose utilization is still very limited is andaliman (Zanthoxylum sp), the Rutaceae tribe which is a typical Batak cooking spice. This study uses a systematic review method. The data used in this study are from research results that have been published in national and international journals. The results of a search for journal publications related to Andaliman Antibacterial Activity (Zanthoxylum sp) for the first phase of the 2012-2022 publication period obtained 34 domestic and foreign journal publications. After conducting a review based on the criteria, 14 journals were selected, 6 Indonesian language journals and 8 English language journals. 24 journals were excluded because they did not meet the criteria. The disc diffusion method is the most widely used method. S aureus and E.coli  most dominant of  data on Minimum Inhibitory Concentration (MIC) related to the antibacterial effect of andaliman (Zanthoxylum sp).
Analisis Tingkat Pemahaman Mahasiswa Jurusan Kesehatan UMS Terkait Penggunaan Obat Bebas dan Obat Bebas Terbatas Untuk Swamedikasi
Authors: Damayanti Alida Rahmalia , Alfiana Mufida , Edelwais Monica , Zulfa Farah Qanitha , Niam Muhammad Labib Qotrun
Published: May 2024

Self medication is an effort to carry out treatment independently. The implementation of self medication must be based on knowledge about self medication itself, one of which is regarding the use of over the counter and limited over the counter drugs. Students majoring in health as potential to be health workers must have a good level of understanding regarding the use of over the counter and limited over the counter drugs in order to provide education to the general public so it can reduce the risk o medication error. The study was conducted using a cross sectional method by collecting primary data from the result of a questionnaire which was then filled out by 78 respondents who were the students majoring in health at the Muhammadiyah University of Surakarta. The research instrument used was tested for its validity and realibility using the SPSS version 16.0 program. From the validity and reliability tests, 10 questions were valid and the insrument used were reliable. Based on the research conducted, it was found that students majoring in health at the Muhammadiyah University of Surakarta have a sufficient level of understanding regarding to the use of over the counter and limited over the counter drugs for self medication with an average score of 68,08.
PEMANFAATAN LIMBAH KULIT JERUK NIPIS (Citrus aurantifolia) DAN SERBUK KOPI ARABIKA (Coffea sp) DALAM FORMULASI PEMBUATAN LULUR TRADISIONAL TAHUN 2022
Authors: Sulasmi Sulasmi
Published: May 2024

Lime peel and coffee grounds are good natural ingredients and have the potential to be used as cosmetic preparations, one of which is used to make body lulur preparations because lime peel contains vitamin C which can absorbs oil from the skin and removes dead skin cells so that the skin looks cleaner, softer and brighter, while the brewed coffee grounds have antioxidant activity, which contains 3.88% of antioxidants and 1-1.5% of caffeine contained in coffee grounds. This study aims to determine which lime peel and coffee grounds can lighten the skin in 2 weeks and to find out which formulation is the best. The lulur acceptability test includes a softness test, iritation test, ease of cleaning and skin brightness. then the lulur was tested for acceptability during week 0 to week 2. Based on the graph, formulation I with a concentration of 5%:10%, formulation II with a concentration of 10%:5% and formulation III with a concentration of 10%:10% are significant formulas for brightening the skin of some respondents. So it can be concluded that there is an effect of skin tone on the use of body lulur preparations at room temperature during week 0 to week 2.
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SALAM ( SYZYGIUM POLYANTHUM WIGHT) TERHADAP KADAR GLUKOSA DARAH PADA MENCIT PUTIH YANG DI INDUKSI ALOKSAN
Authors: Meliala Linta
Published: May 2024

Effect of Ethanol Extract of Bay Leaf (Syzygium polyanthum Wight.) Against Blood Glucose Levels In Alloxan Induced White Mice. Thesis, Department of Pharmacy, Faculty of Pharmacy, Deli Husada Deli Tua Health Institute. (Supervised by: apt. Linta Meliala, S.Si.,M.Si.) Diabetes mellitus (DM) is a metabolic disorder which is characterized by an increase in blood glucose levels. Obesity and overweight are risk factors for type 2 diabetes (WHO, 2019). One of the non-pharmacological drugs that can be used for diabetes mellitus is bay leaf. Bay leaves (Eugenia polyantha) are spread in various areas, both in the mountains and in the lowlands. To determine the antidiabetic activity of the ethanolic extract of bay leaf (Syzygium polyanthum Wight.) in alloxan-induced mice compared with glibenclamide.Experimental study using 25 mice induced with alloxan and divided into 5 groups. Group 1 (negative control) CMC Na 0.5%, group 2 (positive control) Glibenclamide dose 0.0026 mg/kgBW, group 3 bay leaf extract at 250 mg/kgBW, group 4 bay leaf extract at 500 mg/kgBW, group 5 bay leaf extract dose of 750 mg/kgBW. Extraction using maceration method with 96% ethanol as solvent. From the results of the study, each treatment group experienced a decrease in blood glucose levels. Of the 5 treatment groups, the best reduction in blood glucose levels was glibenclamide. The positive control of glibenclamide produced a faster reduction effect than the ethanolic extract of bay leaf. The greatest effectiveness in the ethanol extract of bay leaf 750 mg/kgBW with a faster decrease in blood glucose levels was almost equivalent to the positive control. Ethanol extract of bay leaf (Syzygium polyanthum) can reduce blood glucose levels in male white mice induced with alloxan
STUDI ETNOBOTANI TANAMAN OBAT SEBAGAI PENCEGAH STUNTING OLEH MASYARAKAT WALI NAGARI SIJUNJUNG KABUPATEN SIJUNJUNG, SUMATERA BARAT
Authors: Yesika Relin
Published: May 2024

Stunting is the impaired growth and development that children experience from poor nutrition, repeated infection, and inadequate psychosocial stimulation. Children are defined as stunted if their height-for-age is more than two standard deviations below the WHO Child Growth Standards median. Malnutrition that occurs during pregnancy can lead to stunting which usually appears after the baby is 2 years old. One of the efforts to prevent stunting is consuming a balanced nutritious diet. Many plants and herbs have good nutritional value that can prevent stunting. Plants that have nutritional value can be processed into food that can prevent stunting. This research is a qualitative descriptive method, research has been carried out with the stages of compiling research objectives, observations, interviews, documentation. This research was carried out to answer the need for information related to plant data used to prevent stunting by the community in Wali Nagari, Sijunjung Regency, West sumatera. There were 41 residents in Wali nagari as respondents. The plants most commonly used by the community in Wali Nagari as stunting prevention plants are cassava leaves, spinach leaves, legumes or nuts, katuk leaves, aromatic ginger, kelor leaves, temulawak, pegagan or gotu kola leaves, etc
ANALISIS KANDUNGAN KAFEIN PADA MINUMAN KOPI SIAP SAJI MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS-GAMBAR DIGITAL
Authors: Rahayu Ni Luh Ika , Fernanda M.A. Hanny Ferry
Published: May 2024

Caffeine is a colorless, crystalline powder that has a slightly bitter taste. One of them is ready-to-drink coffee, which can help increase concentration and is much loved. This study aimed to develop a semi-qualitative analysis of caffeine compounds in ready-to-drink coffee using the TLC method. The mobile phase used was methanol: ethyl acetate: acetic acid (3:1:6) with a saturation time of the mobile phase in the chamber of 20 minutes, and the stationary phase used silica gel 60 F254. The results obtained have a linearity (r) of 0,991413. As for the caffeine content in ready-to-drink coffee brand A was 99,37 mg; brand B was 144,81 mg, and brand C was 96,42 mg. It can be concluded that digital image processing using the semi-quantitative TLC method of ready-to-drink coffee contains positive caffeine compounds
ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO
Authors: Khoirunnisa Azka , Jamil Ahmad Shobrun , Muchlisin M. Artabah
Published: May 2024

Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.
FORMULASI DAN EVALUASI SEDIAAN SERUM WAJAH EKSTRAK ETANOL KOMBINASI DARI EKSTRAK KULIT JERUK NIPIS (Citrus aurantiifolia) DAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)
Authors: Simorangkir Delisma , Irmayanti Nina
Published: May 2024

Background: The skin of the key orange (Citrus aurantiifolia) contains kuersetin, miristin, routinely, tangerine, naringin and hesperine, while the skin of the red dragon fruit (Hylocereus polyrhizus) contains betaalanin, anthocyanin, vitamin a, vitamin a, vitamin e, turnioid, flavonoid, tiamin, niacin, piridoine, kobalamin, carotene, and fitoalbumin. The research was intended to formulate it in a availability of facial serum and then evaluate its quality formula for a better facial serum from 16-4954-1998. Methods : This method of research is experimental in the laboratory by making 4 formulas consisting of  F1 as serum bases, F2 ratio     EKJN and EKBNM (1:1), F3 ratio EKJN  and EKBNM (1:2) ,F4 ratio EKJN and EKBNM  (2:1).Results : The results of all the formulas for existing existing face-serum EKJN ethanol and EKBNM viscers show a clear, clear, yellowish color, a gel-based, characteristic and homogenous odor. pH and viscosity scores on each condensed formula. No irritation test on the formula showed irritation to the skin.Conclusion : Based on this, it can be concluded that the combined ethanol extract of lime peel extract and red dragon fruit peel extract can be formulated into a facial serum cosmetic preparation and meets the quality requirements according to SNI.
FORMULASI SEDIAAN KRIM EKSTRAK ETANOL JAHE MERAH (Zingiber Officinalis var.Rubrum) SEBAGAI ANTIDIABETIC FOOT
Authors: Faradina Anniza
Published: May 2024

Red ginger is used as a medicinal raw material because it contains 3% oleoresin which has anti-inflammatory, antioxidant, and anti-bleeding properties. In addition, red ginger contains volatile oil (2.58%-2.72%). Red ginger has long been used as medicine to treat a wide range of diseases, including preventing Staphylococcus aureus. Diabetic foot is caused by the pathogenic bacteria Staphylococcus aureus. The purpose of this study was to use experimental research to create a cream formula with ethanol extract of red ginger. Previous research shows that red ginger extract (Zingiber Officinalis Var. Rubrum) has an 80% inhibition zone of 13.11 mm against Staphylococcus aureus bacteria. It can be concluded that Formula 3 (propylene glycol 15%, TEA 3%, oleum rosae drops, cetyl alcohol 3%, and distilled water 50 ml) can be used to make red ginger ethanol extract cream as antidiabetic foot cream.
Penyuluhan Menstruasi Untuk Menurunkan Kecemasan Menghadapi Menarche Pada Remaja Putri Di SMP Itdokter Tengku Hanafi Sei Buluh Kec. Perbaungan
Authors: Manik Maria Hermita
Published: May 2024

Anxiety about menarche is a state of feeling characterized by physical tension, worry and the assumption that something bad will happen during menarche. This service aims to provide counseling and counseling for dealing with menarche for young women, service partners with Doctor Tengku Hanafi Sei Buluh IT Middle School, Perbaungan District. The service method used is by providing education about Menarche and counseling related to anxiety in dealing with menarche. The results of the service showed that 17 people did not experience anxiety, 12 people had mild anxiety and 2 people experienced moderate anxiety.