bluuebunny/crossref_metadata_2025 huggingface dataset:
To understand climate change adaptation we must characterize climate variability. Here’s how.
Authors: Pisor Anne , Touma Danielle , Singh Deepti , Jones James Holland
Published: February 2023

Climate change adaptation involves the management of climate-related risks, and the IPCC says we must prioritize adaptation immediately. However, researchers and policymakers have little systematic understanding of which adaptations are effective at reducing risks, including under different climate conditions. Drawing on data from human communities past and present, we review how features of climate variability—temporal autocorrelation, frequency, and severity—may predict which candidate climate change adaptations communities innovate or adopt. Using a case study of climate and remittances in Africa, we outline how researchers can characterize features of climate data relevant to adaptation—autocorrelation, frequency, and severity—and then qualitatively compare these data to candidate adaptations. We include suggestions for how to involve communities in these explorations, from setting climate thresholds to identifying impactful hazards. By better understanding the relationship between climate variability and common solutions used by communities, researchers and policymakers can better support communities as they adapt to contemporary climate change.
Differential expression of RAB3IP in pancreatic cancer.
Authors: Mamoor Shahan
Published: February 2023

Cancer is a leading cause of death and pancreatic cancer is among the most lethal cancers (1, 2). We mined public and published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with pancreatic cancer, pancreatic adenocarcinoma (PDAC). We found significant differential expression of the gene encoding RAB3A-interacting protein, RAB3IP, when comparing pancreatic tumors to the tissue of origin, the pancreas. RAB3IP mRNA was present at significantly lower quantities in tumors of the pancreas as compared to normal pancreatic tissue. Analysis of human survival data revealed that expression of RAB3IP in pancreatic tumors was correlated with overall survival in patients with pancreatic adenocarcinoma. RAB3IP expression changes may be important for the initiation or progression of human PDAC.
Comparing serial reproduction and serial prediction of random walk
Authors: Huang Jiaqi Adam , Busemeyer Jerome R
Published: February 2023

Existing studies of the serial reproduction paradigm focused on stimuli that were statistically independent of each other. We explored serial reproductions of random walk series and examined whether Bayesian models previously built for independent stimuli could be adapted to autocorrelated stimuli. We found that Bayesian models captured most of the empirical result qualitatively, but could be further improved by incorporating recency effects. Besides, given that the optimal strategy of iterative prediction of random walk was to reproduce the current stimuli, we also compared serial prediction of random walk to serial reproduction. We found that serially reproduced and predicted series both decorrelate as a function of chain position and that the mean of the series significantly in both tasks, which matched qualitative predictions of the Bayesian models.
Does self-harm have the desired effect? Comparing non-suicidal self-injury to high-urge moments in an ambulatory assessment design
Authors: Störkel Lisa , Niedtfeld Inga , Schmahl Christian , Hepp Johanna
Published: February 2023

All theoretical models of non-suicidal self-injury (NSSI) posit that regulation of negative affect (NA) is a central motive for NSSI, and cross-sectional work supports this. However, previous ambulatory assessment (AA) studies that examined NSSI found mixed results. We investigated the affect regulation function of NSSI in 51 women with DSM-5 NSSI disorder in a 15-day AA study with five random daily prompts and self-initiated NSSI prompts. We extend previous work by i) comparing NSSI moments to moments of a high-urge for NSSI, ii) adding high-frequency sampling following NSSI and high-urge moments, and iii) including tension as a dependent variable. We hypothesized that NA and tension would show a steeper decrease following NSSI than following high-urge moments, if NSSI was effective in reducing NA and tension. Results showed that the significant linear NA decline following NSSI was not steeper than that following high-urge moments. For aversive tension, we found that NSSI was associated with a significant linear decrease in tension, whereas resisting an urge was not. High-urge moments were better described by an inverted U-shaped pattern, likewise leading to decreased NA and tension following the reported urge. In exploratory analyses, we provide visualized clustering of the NA and tension trajectories surrounding NSSI using k-means and relate these to participants’ self-rated effectiveness of the NSSI events. Findings indicate that resisting an urge may also be effective in managing NA and tension and underline the utility of interventions such as urge-surfing.
The ever-growing case for clozapine in the treatment of schizophrenia: an obligation for psychiatrists and psychiatry
Authors: Bittner Robert , Reif Andreas , Qubad Mishal
Published: February 2023

A still expanding body of evidence unequivocally supports the superior efficacy of clozapine compared to other antipsychotics for a considerable number of outcome measures in the treatment of schizophrenia including positive symptoms, negative symptoms, aggression and suicidality. Therefore, clozapine remains the gold standard not only for treatment-resistant schizophrenia but also for a larger number of patients with a poor course of illness. Furthermore, recent meta-analytical evidence clearly demonstrates the superiority of clozapine for reducing all-cause mortality. This finding indicates that clozapine is one of the most potent means to reduce the outrageous mortality gap faced by patients with schizophrenia. Despite its unmatched and wide-ranging efficacy as well as its cost effectiveness, clozapine remains alarmingly underutilized throughout the industrialized world even though patients’ acceptance of clozapine treatment is surprisingly high. While limited, existing evidence indicates that this is primarily due to psychiatrists’ concerns regarding safety and side effect management possibly resulting from insufficient clinical training in using clozapine. This would imply that many patients are never offered clozapine in the first place despite a clear indication. We argue that psychiatrists have an urgent obligation to address this issue and ensure sufficient availability of this vital treatment option. If our fields’ commitment to shared decision-making is to be genuine, we must not exclude patients from the potentially life-changing decision to initiate clozapine treatment. Therefore, concerted research and mental-health policy efforts should focus on identifying barriers for clozapine utilization and effective measures to overcome them. On the one hand, this will require structural changes to clinical training and care systems. On the other and hand – and at least as important – it will require a continued commitment of individual psychiatrists to align their attitudes and clinical practices more closely with the existing evidence and patient preference. The benefits for patients, their families, clinical psychiatry and society will be substantial.
HOW TO CLIMB THE HOLY MOUNTAIN: SHALBUZDAG PILGRIMAGE INFRASTRUCTURAL PROJECTS
Authors: Kapustina Ekaterina
Published: February 2023

Mount Shalbuzdag, located in southern Dagestan, on the border with Azerbaijan, is not only one of the highest peaks of the republic, but is also an important pilgrimage destination for this region. The pilgrimage route includes an ascent to nearly the top of the mountain and a visit to a number of holy places on the way to it. The inaccessibility of the place of pilgrimage has led to a greater dependence of the pilgrims on the infrastructure which, to a greater extent, is maintained by the Miskindzha community located at the foot of the mountain. The article discusses the functioning of infrastructure that serves the pilgrims and its role in the economic and political life of the local community. The hegemony of the Miskindzha pilgrimage infrastructure is challenged both by neighbouring villages as well as by big businessmen and government officials. Also, in addition to the location of the pilgrimage on the slope of the mountain, there is another infrastructure system associated with mountain climbing—a climbing base nearby which also has an impact on competitive infrastructure projects in the vicinity of Shalbuzdag. The article is based on field materials collected during the principal investigator’s field work in the Dokuzparinsky district of Dagestan in 2017–2021.
Twin Deficit Hypothesis: A Study of Nepal
Authors: Bhatt Naw Raj , Karki Babu Ram
Published: February 2023

This paper aims to examine the causal relationship between the budget deficit and the current account deficit of Nepal using time series data sets for the period from 1975 to 2019. Based on the Autoregressive Distributed Lag (ARDL) Model, the empirical finding indicates that rising budget deficits put more stress on the current account deficits in the both long-run and the short-run. Furthermore, the Granger Causality test reconfirms that unidirectional causation runs from budget deficit to current account deficit, which supports the conventional theory of the positive relationship between fiscal and external deficits, i.e. the twin deficit hypothesis for Nepal. The probable adverse effects that arise from such kind of relationship in the economy should be incorporated by the government of Nepal and concerned stakeholders by adopting appropriate policy measures as well as its effective implementation.
Impact of Remittances on Trade Deficit in Developing Countries: The Case of Nepal
Authors: Paudel Ramesh Chandra , Ranjit Yogesh
Published: February 2023

The paper examines the impact of remittances on trade deficits of Nepal, one of the major concerns of the policymakers and stakeholders at the current time. Using the annual data for the period of about two and a half-decade that is from 1996 to 2019. For this purpose, this paper employs the autoregressive distributed lag (ARDL) approach to co-integration considering the time-series properties of the data. The results show that remittances have a strong positive association with trade deficits. Our findings indicate that remittances have contributed to trade deficits both in the long and short run. It suggests a symptomatic presence of ‘Dutch Disease’ leading to erosion in competitiveness and widening trade deficits. One way to reduce the ever widening trade deficit is to create conducive environment to channel the remittance on capital investment that supports the domestic production capacity. This may in turn help on import substitution and promote the exports.
Rethinking Entrepreneurship and School Education: A Developing Country’s Perspective
Authors: Dhungana Nirajan
Published: February 2023

This paper is exploring the role of entrepreneurship literacy education for employment opportunities including self-employment. The concept is explored through the lenses of education as means for economic prosperity, growth and development. The study is carried out by reviewing a range of literature and reviewing the experiences of commercial bank branch managers. These bank managers were inquired utilizing mailed questionnaires about the situation of youth seeking entrepreneurship assistance in their banks and their opinions were sought on how entrepreneurial activities help economic enhancement in the country. The study found that the current education system was neither effective enough for developing entrepreneurship qualities in students nor leading them to entrepreneurship opportunities. It was additionally found that several areas that are appropriate for entrepreneurship are non-incorporated in the current curriculum. The study stresses restructuring the school education by incorporating entrepreneurship competencies, rethinking each course through the perspective of entrepreneurship, adding courses like entrepreneurship guidance within the countries, and arranging extra-curricular activities related to entrepreneurship literacy in collaboration with various stakeholders.
Effect of peptide preparation «Bursanatal» on barrier tissue cells
Authors: M.V Ulitko , Gorshkolepova A.V. , Rakhmanova T.A. , Kolberg N.A.
Published: February 2023

An important condition for the normal existence of the body, protecting it from intoxication and maintaining homeostasis is the ability of barrier tissues to maintain plasticity and the ability to adapt to external influences. In turn, the physiological properties of external and internal barriers depend on the functional activity of their constituent cells. The influence of the tissue peptide preparation "Bursanatal", isolated by enzymatic hydrolysis from the lymphoid tissue of the Fabricius bag of broiler chickens, on the viability and morphofunctional characteristics of cells of barrier tissues: skin fibroblasts, macrophages of the mucous membranes of the respiratory and digestive apparatus was studied. An increase in the viability of all studied cell types was established, as well as an increase in the lysosomal and phagocytic activity of macrophages, without a significant effect on their enzymatic properties. The most pronounced changes in the morphological and functional properties of cells were observed when exposed to a 10% concentration of the drug "Bursanatal".
Effects of Azospirillum lectin on wheat seedling growth under salt stress
Authors: Kupryashina M.A. , Alen’kina Sv.A.
Published: February 2023

Azospirillum brasilense, which has the potential to stimulate plant growth, belongs to plant-growth-promoting bacteria. The positive effect of Azospirillum on plants may be due to different mechanisms. Azospirilla can assist in mitigation of many kinds of abiotic stress. Lectins are glycoproteins with different molecular masses and carbohydrate specificities. Azospirillum lectins are polyfunctional molecules. They promote plant growth and enzyme activity, they also can alter the plant cell content of stress metabolites, which attests that they can induce adaptation processes in wheat seedling roots. We investigated the dose-dependent effects of the lectin from A. brasilense strain Sp7 on the roots of 4-day-old wheat seedlings (Triticum aestivum L. cv. Saratovskaya 29) grown under salt stress. A low lectin concentration (0.3 mM L-1) improved seedling growth and alleviated the stress-induced growth inhibition. However, higher concentrations of lectin (1.2 mM L-1) did not affect the growth of the stressed seedling roots. In the roots of 4-day-old wheat seedlings under salt stress, the Sp7 lectin decreased total protein content and lipid peroxidation, which causes membrane damage, but increased the content of secondary metabolites such as total phenolics and total flavonoids. We conclude that the Azospirillum lectins are involved in adaptational changes in wheat seedling roots, due to which the relationship between bacteria and their hosts can be regulated under changing soil and climatic factors.
Hydrolase activity in leaves of potato treated with rhizobacteria and resistance inductors under Phytophthora infection and moisture deficiency
Authors: Tsvetkov V.O. , Khabibullina V.O. , Gainitdinova Z.V. , Yarullina L.G.
Published: February 2023

Changes in the activity of amylases, proteases, and cellulases in the leaves of potato plants grown under late blight infection and deficiency of soil moisture under the influence of pretreatment with Bacillus subtilis bacteria, salicylic acid (SA), jasmonic acid (JA), and their mixture were studied. In plants treated with B. subtilis in combination with signal molecules, higher amylolytic and proteolytic activity was observed, this effect was especially pronounced when treated with B. subtilis in combination with both signal molecules. Treatment of plants with bacteria together with SA and JA, which activates a whole complex of signaling pathways, can be considered as a potential way to induce plant defense responses to increase resistance to pathogen attack.
The influence of DNA templates composition on nonspecific (ab initio) DNA synthesis
Authors: Khanova L.I. , Garafutdinov R.R. , Sakhabutdinova A.R. , Chemeris A.V.
Published: February 2023

Detection of specific nucleic acids (NA) is the basis of modern methods for DNA and RNA analysis, which is carried out during amplification reactions followed by detection of amplification results. Despite the huge number of NA amplification techniques has been developed, the demand for high reliability is still relevant. This article is related to the specificity of the DNA synthesis reaction. Previously, nonspecific amplification was shown for various DNA polymerases even in the absence of templates and primers. In this study, the propensity of strand-displacement DNA polymerases to provide efficient ab initio DNA synthesis is shown. This property is most intrinsic for thermostable polymerases, which is probably due to the higher efficiency of formation of DNA heteroduplexes suitable for elongation during thermal cycling. Ab initio DNA synthesis proceeds at the highest rate in the presence of double-stranded DNA, oligo-dT18, or templates consisting of nucleotide repeats.
PECULIARITIES OF THE FORMATION OF INFORMATION AND COMMUNICATION COMPETENCE DURING PHYSICAL EDUCATION CLASSES AMONG STUDENTS OF HIGHER EDUCATION INSTITUTIONS
Authors: Syrovatko Z. , Yеfremenko V.
Published: February 2023

The article reveals the peculiarities of the formation of information and communication competence among students of higher education in physical education classes. The influence of physical education on its effectiveness on the development of competences has been revealed. . The analysis of literary sources showed the presence of a whole range of competences, each of which is a set of individual abilities, abilities and skills, and, at the same time, an organic component of the formation of the personality of students of higher education. Thus, the educational process in institutions of higher education is aimed at the development of a competency-based approach to learning, taking into account the requirements of modern society. Scientists from all over the world distinguish a number of competencies for personality development. Each of them on the one hand, it has a highly specialized orientation, and on the other hand, it acts as a complex element of formation of a competent, objectively thinking, creative personality. The information processes of the third millennium gave rise to the formation of a list of competencies students have the ability to use technology, to be part of a computerized society – competence in information and communication technologies. It, in turn, is a multi-component education that accumulates theoretical knowledge with its practical implementation.

The technologies of tomorrow do not need millions of people ready to work in unison on endlessly monotonous jobs, not people who follow orders without blinking. The concepts of "competence" and "competence approaches" are revealed.
Features of the methods of conduct of physical education classes in special medical groups for diseases of the cardiovascular system
Authors: Demydenko M. , Obeziuk T.
Published: February 2023

The theoretical justification of the importance of the methodology of conducting physical education classes in special medical groups for diseases of the cardiovascular system is provided. With the aim of a differentiated approach to the organization of physical culture classes, it was explained that all students of higher education institutions are divided into three medical groups according to their level of health and physical fitness – basic, preparatory and special medical. The special medical group has two levels of complexity – A and B. Based on the research, a methodology for conducting physical education classes in special medical groups for diseases of the cardiovascular system was developed and proposed. A list of non-recommended exercises for students with cardiovascular diseases in physical education classes in special medical groups is provided. At present, given the importance of this topic, there is an insufficient amount of research in the field of the method of applying therapeutic exercises during physical education classes in diseases of the cardiovascular system. The method of conducting physical education classes at the SMG for diseases of the cardiovascular system is an important component of improving the functional state of the sick student's body. Therapeutic exercises are used in various forms for all diseases of the cardiovascular system. They have a positive effect on the functions of the heart and blood vessels, their morphology. The level of theoretical and practical training of physical education teachers and the level of motivation of students with cardiovascular diseases are also important when working in special medical groups.
Information and communication technologies in the professional activity of physical culture and sports specialists using the competence approach
Authors: Denysovets T. , Khomenko P. , Dolidze A. , Olefir D.
Published: February 2023

The article examines the main directions of using information and communication technologies (ICT) in the professional activities of physical education managers. Information and communication technologies are defined as processes, methods of search, collection, storage, processing, provision, distribution of information and methods of implementation of such processes and methods.

The introduction of ICT in the educational and training process stimulates interest in educational and training activities, promotes the formation of logical and creative thinking, promotes the development of students and the formation of information culture. Information and communication technologies contribute to the development of the competence of critical thinking and the competence of interpersonal interaction in training work.

The relevance of the application of the researched technologies is substantiated, which is due to the social need to improve the quality of physical education of children of different ages and the educational process in general. The issue of applying the competence approach in the process of physical education as a condition for improving the quality of education is revealed. The mechanisms of implementation of the competence approach, taking into account the individual characteristics of students, were traced.

The complex application of information and communication technologies in the process of physical education is quite relevant for the development of the student's personality and the formation of the following competencies in students: the ability to compare the advantages and disadvantages of various sources of information, to choose appropriate technologies for its search, to create and use adequate models and procedures for studying and processing information, etc.
A system of training tools for variable technical and tactical actions of young freestyle wrestlers
Authors: Maliar E. , Maliar N. , Ognystyy A. , Ognysta K.
Published: February 2023

The analysis of the researches of domestic specialists made it possible to determine a system of effective means of training variable technical and tactical actions of young freestyle wrestlers, namely: components of training variable technique of throwing with a mill, methods of tactical preparation, as well as tools that ensure the implementation of this technique depending on the variability of "entry into reception", different methods of tactical training, different types of grips and various starting positions. As a result of the conducted research, a method of training variable technical and tactical actions of young freestyle wrestlers was developed, which includes: components of training variable technique of throwing with a mill, methods of tactical preparation, as well as means that ensure the implementation of this technique depends on the variability of the "entry into the technique", various methods of tactical training, different types of grips, various starting positions. Here are some provisions of the developed experimental method of teaching variable technical and tactical actions of young freestyle wrestlers. The attacker, having grabbed the opponent's different hand by the wrist, the other - by the shoulder, from the inside begins to perform the translation with a jerk. Releasing the wrist and placing the far leg forward between the opponent's legs, and putting the near one on the knee, the attacker dives under the opponent's chest so that his shoulder blades are completely covered by the opponent's chest, all the while continuing to pull his arm of the same name on his neck. With the free hand, grab the hip of the same name from the inside and, pushing off with the front leg to the side, the attacker tears the opponent off the carpet and throws him over the shoulders in the direction of the grabbed arm.
BUSINESS COMMUNICATIONS FROM ENGLISH LANGUAGE POINT OF VIEW
Authors:   Бердянський державний педагогічний університет, NAGAY I.
Published: February 2023

The proposed article is devoted to considering the problems of organizing business communications in higher educational institutions majoring in Economics and Management, as well as the need to improve business communication skills of young professionals. It is well known that the viability of a business directly depends on the ability of managers working in the field of International Business to establish and maintain business contacts with staff, consumers, and business partners. Research in the city of Berdyansk and the Berdyansk region showed that young professionals faced the problem of organizing business communications (BC) when doing business with foreign partners. In this regard, it is very important to increase the level of efficiency of mastering BC skills, which determines the relevance of this work. Knowledge and skills in the field of BC can become a decisive factor for successful business development. Being aware of the priority of Western BC traditions, due to their linguistic and economic position in the world, it should be remembered that Ukraine, like other Eastern European states, has its own communicative style, generously filled with national character and new economic realities. In addition, when preparing future specialists in the field of Foreign Economic Affairs, in the field of International Business, it is necessary to use new, interactive, professionally oriented methods along with traditional training methods. It should be noted that the knowledge acquired by students in the specialty is very important, but does not guarantee successful business development. While business communication skills are crucial. There were developed recommendations to increase the efficiency of business communication skills of future specialists in the field of Foreign Economic Affairs and International Tourism. We believe that it is of great necessity to include into the existing English language study programs special courses that provide an opportunity not only to expand students’ outlook in the field of Philology and Linguistics, to realize their interest in the subject, but also most to master foreign language professional communicative competence, which allows them to use a foreign language as means of business communication to solve specific problems in situations of business interaction. Key words: Business Communications, communicative style, corporate communication, communicative competence.
Modeling the Decision-Making Process when Promoting New Products to the Market
Authors:   National Technical University of Ukraine �Igor Sikorsky Kyiv Polytechnic Institute�, Pyshnograiev Ivan , Dehtiar Daryna ,   National Technical University of Ukraine �Igor Sikorsky Kyiv Polytechnic Institute�
Published: February 2023

Abstract. Introduction. A decision value has making of new products for prosperity of company, as users want and expect new and improved products. Therefore, every company needs own program of development of new product, which foresees a prospect and takes into account properties of commodities, such as a death "rate", that leading out from a market through the certain interval of time. Purpose. A model and econometric approach are presented, it allows to measure the theoretical features of prices quantitatively. In particular, the offered equalization allows to describe speed and terms of price transitions, in that time as we use the design of mixture, to check up relative importance of different triggers of landing of price. Finally, we apply a hierarchical structure for description of the empiric distributing of time and speed of price transitions and simultaneously for the exposure of the most reliable price factors. Results. We find that most of this heterogeneity is due to firm effects. Our model captures this heterogeneity, and it is flexible and useful for predicting and describing price landing patterns in our data. Finally, we find that it is the age of gas generating units that drives the price decline. The next most likely driver is competition and the least likely is cumulative sales volume. The latter finding contradicts the academic convention that sales are the main driver of prices. At least for our application we found strong evidence that sales are not the most likely driver of significant price reductions. Conclusions. Competition and time alone are the main drivers of price reductions, while past sales and product mix are less likely. We also find considerable heterogeneity in the timing and speed of pricing across firms and product types.
Formulasi Nugget Ikan Untuk Mendukung Hilirisasi Produk Olahan Ikan Sebagai Rintisan Teaching Factory di Workshop Teknologi Pengolahan Hasil Perikanan – POLNEP
Authors: Nugroho Teguh Setyo , Adiguna Galih Setyo , Masi Aloysius
Published: February 2023

Abstrak

Pengeringan Hilirisasi produk olahan ikan yang akan menjadi produk rintisan dan unggulan untuk Teaching Factory di Workshop Teknologi Pengolahan Hasil Perikanan – POLNEP menjadi sangat penting dikembangkan. Salah satu produk olahan ikan yang relatif siap di hilirisasi karena mudah proses produksinya, populer di masyarakat, dan memiliki prospek bisnis yang baik adalah nuggets ikan. Tujuan dari penelitian ini antara lain : 1) mendapatkan formulasi dan metode pengolahan nuggets ikan yang tepat dan siap untuk dihilirisasi; 2) mengukur tingkat kesukaan panelis (uji hedonik) terhadap rasa, tampilan, warna, aroma, dan tekstur nuggets ikan hasil percobaan; 3) mendesain kemasan nuggets ikan yang tepat; 4) mengukur daya terima konsumen terhadap nuggets ikan yang ditawarkan; 5) menganalisis kelayakan bisnis pengolahan nuggets ikan. Penelitian ini merupakan penelitian experimen disain dengan menggunakan Rancangan Acak Lengkap (RAL) pada percobaan. Percobaan ke-1 terdiri dari 2 perlakuan dan 3 ulangan. Perlakuan terdiri dari formulasi resep dan metode pengolahan nugget ikan menurut: formulasi Sakana dalam Ayu (2014), dan formulasi Nugroho (2002). Formulasi terbaik selanjutnya digunakan pada percobaan ke-2 juga terdiri dari 2 perlakuan dan 3 ulangan. Pelakuan pertama adalah kombinasi daging ikan rucah Gulama 75 % dan ikan Tengiri 25 %, dan perlakuan kedua adalah kombinasi daging ikan rucah Gulama 75 % dan ikan Malong 25 %. Hasil percobaan menunjukan bahwa Formulasi A menurut Sakana dalam Ayu (2014) yang sudah dimodifikasi dengan menggunakan kombinasi daging ikan rucah Gulama 75 % dan ikan Tengiri 25 % merupakan perlakuan terbaik berdasarkan uji hedonik terhadap rasa, tampilan, warna, aroma, dan tekstur nuggets.

 

Kata kunci: Hilirisasi, produk diversifikasi, nuggets ikan, Teaching Factory,
TEKNIK PEMBENIHAN IKAN NILA (Oreochromis niloticus) DI LABORATORIUM PENGUJIAN KESEHATAN IKAN DAN LINGKUNGAN AMBARAWA KABUPATEN SEMARANG, JAWA TENGAH
Authors: Ambarwati Ninik , Mujtahidah Tholibah
Published: February 2023

Kegiatan pembenihan ikan nila yang diproduksi di Laboratorium Pengujian Kesehatan Ikan danLingkungan (LPKIL) Ambarawa dilakukan dengan pemilihan induk ikan secara fisik dengan ratarata berat 4-1,5 kg dengan benih yang dihasilkan memiliki berat 0, 03 gram dengan panjang 3-5 cmdan siap dipindahkan pada fiber hingga kantong kuningnya hilang selama ± 3 hari, pakan yangdigunakan yaitu pelet halus dan air kolam lele, saat ikan berusia lebih dari 2 minggu dipindahkan kekolam pendederan. LPKIL Ambarawa sebagai pemasaran benih ikan sehingga bagi ikan nila hanyasampai proses pendederan kemudian dipanen dan dipasarkan kepada petani ikan dan pemilik lahandi Rawa Pening. Kegiatan pengamatan dan analisis yang dilakukan pada saat proses satu kalipemijahan menghasilkan perhitungan SR 80,533%, perhitungan SGR 0,047 % per hari, perhitunganHR 86,69%, perhitungan FR 79,3 %, nilai fekunditas 285,71 butir, perkembangan larva dari mingguke 0 sampai ke 3 kisaran angka 0,86 cm -1,64 cm. Nilai rata-rata suhu kisaran 24,64 oC, pH 8,06, danDO 6,98 ppm. Nilai penjualan benih ikan nila berdasarkan takaran dan kg dengan total pembeliandalam satu bulan sebanyak 70 gelas takaran dan 56,9 kg, hasil penjualan ikan nila selama satu bulanRp 3,500,000,-. Analisis hama meliputi keong, kerang, dan ular, untuk penyakit yaitu Streptococcussp, Lerneae sp, dan Tricodina sp dengan sampel pengambilan preparat permukaan tubuh dan insangikan nila. Kategori dalam pembenihan ikan nila secara keseluruhan optimal namun memiliki kendalaakibat faktor internal dan eksternal sehingga belum mencapai target produksi secara maksimal dalamproduksi ikan nila.
REVIEW : PENERAPAN SISTIM HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SEBAGAI JAMINAN MUTU DAN KEAMANAN PANGAN HASIL PERIKANAN
Authors: Vatria Belvi
Published: February 2023

Saat ini sebagian besar negara-negara di dunia terus berusaha memastikan agar makanan yang dikonsumsi masyarakatnya tetap aman dan sehat untuk dikonsumsi. Hazard Analysis and Critical Control Point (HACCP) adalah suatu sistim manajemen mutu dan keamanan makanan termasuk hasil perikanan yang telah diakui efektifitasnya sehingga sebagian besar negara di dunia telah menerapkan HACCP sebagai sistim jaminan mutu dan keamanan makanan di negara mereka. Tujuan penelitian ini adalah menguraikan langkah-langkah penerapan sistim HACCP pada unit pengolahan hasil perikanan. Metode penelitian ini adalah studi kepustakaan melalui analisis deskriptif dengan menguraikan secara teratur berbagai data yang telah diperoleh kemudian disintesis sehingga menghasilkan pemahaman dan konsep yang jelas dan mudah dipahami. Penelitian ini menemukan bahwa sebelum menerapkan sistim HACCP terdapat program pra-syarat yang harus dipenuhi oleh unit pengolahan ikan (UPI). Pemenuhan program pra-syarat ini dimaksudkan untuk memastikan penerapan sistim HACCP dapat berjalan secara efektif dan efisien. Program pra-syarat tersebut terdiri dari: 1) pemenuhan syarat lokasi, lingkungan, bangunan, peralatan, 2) penerapan standar prosedur operasi pengolahan, 3) pemenuhan persyaratan standar prosedur operasi sanitasi, dan 4) program prasyarat lainnya seperti; program ketelusuran produk, prosedur penanganan keluhan pelanggan, dan pelatihan karyawan. Penelitian ini juga menemukan bahwa terdapat 12 langkah dalam penerapan sistim HACCP yaitu: 1) pembentukan tim HACCP, 2) deskripsi produk, 3) dentifikasi penggunaan produk, 4) penyusunan diagram alir, 5) konfirmasi diagram alir di lapangan, 6) analisis bahaya, 7) penentuan CCP, 8) penentuan batas kritis, 9) penyusunan sistem pemantauan pada setiap CCP, 10) penetapan tindakan koreksi, 11) penetapan prosedur verifikasi, dan 12) penetapan prosedur pencatatan.
Pengembangan Produk Olahan Ikan Smoked Catfish Kabayaki Berbahan Baku Ikan Lokal Dengan Metode Pengasapan Cair
Authors: Putra Yudha Perdana , Laksono Untung Trimo , Primadini Vivin
Published: February 2023

Kabayaki merupakan teknik memasak khas Jepang yang diterapkan pada fillet ikan dengan potongan memanjang yang dipanggang dengan olesan saus tare. Inovasi berupa substitusi bahan baku yang lebih ekonomis perlu dilakukan untuk lebih memanfaatkan peluang pasar yang ada dimana bahan baku potensial yang tersedia secara lokal untuk produk berbasis kabayaki yaitu ikan dari kelompok catfish, antara lain ikan lele, patin, dan manyung yang dioleh dengan metode pengasapan cair. Tahapan penelitian terdiri dari 2 tahap yaitu optimasi suhu dan waktu pemasakan untuk masingmasing jenis produk smoked catfish kabayaki serta mengujia tingkat kesukaan pada masing-masing jenis produk. Suhu dan waktu pemasakan optimum yang direkomendasikan adalah pada suhu 150 0 C dengan waktu pemasakan selama 30 menit yang memberikan kenampakan dan tekstur produk terbaik. Hasil pengujian tingkat kesukaan konsumen menunjukkan bahwa varian produk smoked catfish kabayaki yang paling disukai adalah produk dengan bahan baku ikan patin dengan nilai tingkat kesukaan konsumen 7 pada parameter Kenampakan dan Rasa, serta 6 pada parameter Aroma, Tekstur, dan Flavor Asap.
The Perceived Value For International Halal Makeup Product In Thailand
Authors: Ismaja Delvicka , Kijkasiwat Ploypailin
Published: February 2023

The current level of awareness of halal cosmetics is still low. The main reason behind this phenomenon lies in the scarcity of halal cosmetics on the market. Due to a lack of understanding of halal and haram/halal, consumers in turn lack awareness of halal products. Despite the industry's potential, consumers are not adequately exposed to halal brands, and as a result, halal cosmetic items have a poor level of reactivity. Gaining a better understanding of how consumers view halal cosmetic brands is essential. Most of the available literature on halal matters has primarily been undertaken in food science, with studies on the cosmetic business receiving little attention. Even though a few studies on halal cosmetics exist, most of them rely on anecdotes and case studies, with the majority considering the role of theory of reasoned action (TRA) in purchasing behavior. Thus, this study aimed to examine Thai people's knowledge about halal makeup and their awareness, and how product quality and perceived value can influence customer satisfaction. Data were collected using online questionnaires distributed to the consumers selected by the clustered sampling method. The questionnaires were distributed in some areas across the provinces in Thailand. The population was makeup users, e.g., Thai people or Muslin or non-Muslim people residing in Thailand. With Thailand’s population of 70,030,726, a sample of 400 consumers in various regions in Thailand, e.g. men and women with an age range of 16-50 years, was invited to fill out a research questionnaire based on the aims and interests of the research.
"South Asian Woman's Identity: A Comprehensive Analysis of Zara Raheem's "The Marriage Clock"
Authors: Jabeen Rimsha , Rukh Harmain , Naqvi Syeda Kashf Zahra
Published: February 2023

Second-generation South Asian immigrants most often experience cultural hybridity where the task to balance between the home culture and the culture of the new world is gruesome for many. Understanding cultural hybridity signifies that transcultural relations are complex, processual and dynamic (Kraidy, 2002). This paper aims to find out the issues faced by South Asian women in embracing their home culture and its norms completely. It further notices how cultural diversity impacts a South Asian woman in shaping her identity and the perceptions of first generation immigrants with respect to the hybrid culture. The paper tends to observe how the traditional “matchmaking” process in association with marriage in South Asian culture works for a woman in the light of Zara Raheem’s “The Marriage Clock” (2019). A qualitative study is carried out for conducting the research where Bhabha’s “Theory of Hybridity & Third Space” (1995) is employed for interpreting the transcultural relationships present within the book.
Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies
Authors: Wang Weijun , He Haiping , Zeng Shan , Cho Hee-Yeon , Minea Radu O. , Swenson Steven D. , Zheng Long , Epstein Alan L. , Stathopoulos Apostolos , Chen Ligang , Schönthal Axel H. , Chen Thomas C.
Published: February 2023

OBJECTIVE

Immune checkpoint-inhibitory therapeutic antibodies have shown striking activity against several types of cancers but are less effective against brain-localized malignancies, in part due to the protective effect of the blood-brain barrier (BBB). The authors hypothesized that intraarterial (IA) delivery of a novel compound, NEO100, has the potential to safely and reversibly open the BBB to enable brain-targeted therapeutic activity of checkpoint-inhibitory antibodies.

METHODS

Immunocompetent mice with syngeneic glioblastoma or melanoma cells implanted into their brains were subjected to a single IA injection of NEO100 to open their BBB. One dose of murine anti–PD-1/PD-L1 antibody was either coinjected with NEO100 or separately injected intravenously. Brain penetration of these antibodies and levels of CD8+ T cell infiltrate into the tumor microenvironment were quantitated and animal survival was monitored.

RESULTS

IA NEO100 enabled the increased accumulation of checkpoint-inhibitory antibodies in the brain, along with greater numbers of T cells. In both malignancy models, a single intervention of IA NEO100 combined with antibody resulted in the long-term survival of animals. Antibody treatment in the absence of NEO100 was far less effective.

CONCLUSIONS

BBB opening by IA NEO100 facilitates brain tumor access by checkpoint-inhibitory antibodies and enables their therapeutic activity, along with increased levels of T-cell recruitment.
B-Lynch Suture Management among Patients with Postpartum Hemorrhage in a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Koirala Poonam , Ghimire Asmita , Bista Kesang Diki
Published: February 2023

Introduction: Postpartum haemorrhage is the most life-threatening complication during pregnancy and atonic postpartum haemorrhage being the commonest one, often poses difficulties in management. B-Lynch suture with a high success rate has emerged as a life-saving measure in uncontrolled atonic postpartum haemorrhage refractory to uterotonics. The objective of this study was to find out the prevalence of B-Lynch suture management among patients with post-partum haemorrhage in a tertiary care centre.

Methods: This descriptive cross-sectional study was conducted in the Department of Obstetrics and Gynecology of a tertiary care centre from 1 April 2017 to 1 April 2021 after taking ethical approval from the Institutional Review Committee of the same institution [Reference number: 497(6-11)C-2077/078]. All patients with post-partum haemorrhage during the study period were included in the study. Patients with traumatic post-partum haemorrhage, congenital malformations, complete placenta previa/accreta, bleeding disorders, disseminated intravascular coagulation, and retained bits of placenta were excluded from the study. A convenience sampling method was used. Point estimate and 90% Confidence Interval were calculated.

Results: Out of 72 patients, 19 (26.39%) (17.85-34.93, 90% Confidence Interval) underwent B-Lynch suture management for atonic post-partum haemorrhage. Uterus salvage was done in 18 (94.74%) whereas 1 (5.26%) underwent a cesarean hysterectomy.

Conclusions: The prevalence of the use of B-Lynch suture was similar to other studies done in similar settings. B-Lynch suture is a valuable addition for controlling intractable atonic primary postpartum haemorrhage refractory to uterotonics, thus saving the life as well as preserving the future fertility of the woman.
Mean Bone Density in Interadicular Areas of Maxilla among Patients Visiting Dental Unit of a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Halwai Hemant Kumar , Kamble Ranjit Haridas , Yadav Sumit Kumar , Gupta Sandeep Kumar , Shrestha Raju , Daigavane Pallavi , Gilani Rizwan
Published: February 2023

Introduction: A close relationship occurs between the type of bone density and the success of orthodontic mini-implant. The aim of this study was to find out the mean bone density in interradicular areas of the maxilla among patients visiting dental unit of a tertiary care centre.

Methods: A descriptive cross-sectional study was performed at the Department of Orthodontics and Dentofacial Orthopedics at a tertiary care centre from 15 January 2022 to 28 June 2022 after taking ethical approval from the Institutional Review Committee (Reference number: UCMS/IRC/175/21). Data was collected from scan reports obtained with a computed tomography scanner. Bone density was measured at 6 mm height from the alveolar crest. Convenience sampling was done. Point estimate and 95% Confidence Interval were calculated.

Results: Out of 70 patients, mean bone density at interradicular areas of maxilla was 992.31±204.20 HU (944.46-1040.13, 95% Confidence Interval). Between central and lateral incisor 50 (71.44%) had D2 type of bone density.

Conclusions: The mean bone density in inter radicular areas of the maxilla among patients visiting the dental outpatient department was similar to other studies done in similar settings.
Pleomorphic Adenoma: A Case Report
Authors: Bhor Ketaki , Tamgadge Avinash , Pereira Treville , Manishankar Suraj , Kathe Atharva Anil , Suryanarayan Mahek
Published: February 2023

Introduction: Pleomorphic adenoma is a benign salivary gland tumour that most commonly originates in the parotid gland, mainly involving the superficial lobe. Pleomorphic adenoma is a painless growth that grows in size over time if left untreated. It is more common in women and occurs between the ages of 30 and 60. Surgical excision exposes the facial nerve to injury as it penetrates the substance of the parotid gland and separates into terminal branches. Case Report: We discuss a case of a pleomorphic adenoma of the right parotid gland presented by a 35-year-old lady and handled by surgical excision, as well as details of the critical structures encountered. Conclusion: Despite being a benign tumor of the salivary gland, pleomorphic adenoma should be detected early, and complete local surgical excision with negative microscopic margins is advised. Whenever possible, care should be taken to protect the facial nerve when dealing with the parotid gland. For preventing recurrence and malignant transformation, care must be made to completely eradicate the lesion.
Verruciform Xanthoma: A Case Report
Authors: Jadhav Abhishek , Kamath Pooja , Punjabi Vishal , T K Priyadharshini , Sahil S  , Savale Sourabh
Published: February 2023

Introduction: Shafer first described the entity Verruciform Xanthoma (VX) in the year 1971 as an uncommon lesion of the mucosa of the oral cavity with unknown etiopathology. It is a papillary, polypoid or sessile growth that is usually non-symptomatic in nature. There is no gender predilection. It is reddish in color but sometimes may appear pale or hyperkeratotic with a cauliflower-like growth. The size of the lesion ranges from 2mm to 2cm or more. The hallmark and distinguishing feature of VX is the presence of lipid-laden foamy histiocytes usually present in the papillary region of the connective tissue. Case Report: Here we present a case of a 63-year-old male patient with a chief complaint of a whitish growth on the lower anterior gingiva which was firm in consistency measuring about 2 x 1 cm. A biopsy was taken and it was sent for histopathological diagnosis of the same. Conclusion: Verruciform xanthoma is a rare benign proliferative lesion of the oral cavity, characterized by the presence of foam cells within the connective tissue papillae. It is important to make the correct diagnosis for verruciform xanthoma by histopathology because of its resemblance to papilloma and other verrucous lesions.