bluuebunny/crossref_metadata_2025 huggingface dataset:
Perbaikan Proses Produksi dan Peningkatan Pemasaran pada UKM Putri Timus Di Karanganyar
Authors: Giyanti Ida , Suparti Erni , Sunardi Sunardi , Sugiarti Sugiarti
Published: May 2021

Abstract: Timus is one of the famous traditional foods in the Central Java region. Putri Timus is one of the Small Medium Enterprise (SME) in Karanganyar district producing purple Timus. Timus from Putri Timus have one special feature, in which in the inside of the Timus contains Bligo (Benincasa hispida) fruit with various benefits. Although Putri Timus has product differentiation, product by Putri Timus is not well known to the public. The production process was carried out on a home scale and has not fully implemented production standards based on the criteria for Good Food Manufacturing Practices for Home Industry (CPPB-IRTP). This community service program aims to help Putri Timus to implement hygiene requirements in food production based on CPPB-IRTP criteria and increase its marketing capacity. The method used to solve the problems were training of Good Food Manufacturing Practice, improvement of production place, facilitation of production cloths and promotional media. The results obtained after community service activities related to the production aspect were increasing knowledge regarding good food production process and improvement of production place. Regarding the marketing aspect, several promotional media have been installed. In addition, there was also an increasing of sales and profit.         Keywords: traditional food; small medium enterprise; production; marketing  Abstrak: Timus adalah salah satu makanan tradisional yang terkenal di Jawa Tengah. Putri Timus adalah salah satu Usaha Kecil Menengah di kabupaten Karanganyar yang memproduksi timus ungu. Produk dari Putri Timus memiliki satu keistimewaan yakni bagian dalam timus berisi buah Bligo (Benincasa hispida) dengan beragam manfaat. Meskipun produk memiliki diferensiasi, timus isi Bligo hasil produksi Putri Timus belum cukup dikenal masyarakat. Proses produksi dilakukan dalam skala rumahan dimana Putri Timus belum sepenuhnya menerapkan standar produksi berdasarkan kriteria Cara Produksi Pangan yang Baik – Industri Rumah Tangga Pangan (CPPB-IRTP). Program pengabdian masyarakat ini bertujuan membantu Putri Timus untuk dapat menerapkan syarat higiene dalam produksi pangan berdasarkan kriteria CPPB-IRTP serta meningkatkan kapasitas pemasaran. Metode yang digunakan untuk mengatasi permasalahan mitra ialah melalui penyuluhan tentang CPPB-IRTP, pembenahan tempat produksi, fasilitasi pakaian produksi dan media promosi. Hasil yang diperoleh setelah kegiatan pengabdian terkait aspek produksi ialah adanya peningkatan pengetahuan karyawan tentang  CPPB-IRTP dan perbaikan tempat produksi yang lebih bersih dan layak. Terkait aspek pemasaran, beberapa media promosi telah dibuat dan dipasang. Selain itu juga terdapat peningkatan jumlah penjualan dan laba dari hasil penjualan timus.Kata kunci: makanan tradisional; produksi; pemasaran; usaha kecil dan menengah.
ВИКОРИСТАННЯ ЗАСОБІВ ІКТ ДЛЯ ФОРМУВАННЯ ФАХОВОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ УЧИТЕЛІВ МУЗИЧНОГО МИСТЕЦТВА
Authors: Ашихміна Наталія Віталіївна
Published: May 2021

У статті проаналізовано значення інформаційно-комунікаційних технологій для формування основних компонентів фахової компетентності здобувачів вищої освіти мистецьких факультетів педагогічних університетів. Визначено сутність фахової компетентності майбутніх учителів музичного мистецтва. На думку автора, означене поняття – інтегративна якість, що є характеристикою набутих фахових знань, умінь, навичок, сформованих особистісних якостей під час фахової підготовки в межах мистецько-педагогічного вишу для якісного виконання професійної діяльності. Структура досліджуваного феномена складається з таких компонентів: мотиваційно-ціннісного, фахово-когнітивного, фахово-діяльнісного і рефлексивно-творчого. Зроблено висновок про те, що формування фахової компетентності майбутнього вчителя музичного мистецтва є цілеспрямованим, безперервним і поетапним процесом особистісного прогресивного перетворення й удосконалення відповідно до вимог професійної музично-педагогічної діяльності. Автором запропоновані можливі організаційні дії для успішного формування досліджуваного феномена в межах мистецько-педагогічного вишу. Як імовірні ефективні способи формування основних компонентів фахової компетентності майбутніх учителів музичного мистецтва розглянуто певні засоби ІКТ. Зроблено такі припущення: формуванню мотиваційно-ціннісного компонента сприятиме залучення здобувачів вищої освіти до створення мультимедійних самопрезентацій і цифрових портфоліо в програмах PowerPoint та Authorware; формуванню фахово-когнітивного компонента – проєктування електронного підручника (або його фрагмента) у таких програмах: E-Book Maestro й Help and Manual E-Book; формуванню фахово-діяльнісного компонента – використання нотних редакторів (Finale, Sibelius, Encore); формуванню рефлексивно-творчого компонента – застосування звукових редакторів (Sound Forge, Sternberg WaveLab) і музичних конструкторів (SunVox, NanoStudio, MadTracker, MuLab).
ФОРМУВАННЯ НАВИЧОК ЦИФРОВОЇ БЕЗПЕКИ МАЙБУТНІХ ФАХІВЦІВ З ЕКОНОМІКИ
Authors: Глазунова Олена Григорівна , Саяпіна Таїсія Петрівна , Касаткіна Ольга Михайлівна , Корольчук Валентина Ігорівна , Волошина Тетяна Володимирівна
Published: May 2021

У сучасних умовах цифровізації різних сфер життєдіяльності важливою характеристикою учасників цифрового суспільства є рівень їх цифрової безпеки. З розвитком цифрової економіки навички цифрової безпеки вимагаються від усіх фахівців цієї сфери. Від рівня сформованості навичок цифрової безпеки в майбутніх економістів під час навчання в закладі вищої освіти залежить їх успішне працевлаштування та розвиток кар’єри. У поданій статті проаналізовано поняття цифрової безпеки майбутнього економіста, охарактеризовано її рівні: «цифрове громадянство», «цифрова творчість», «цифрове підприємництво». Проаналізовано зміст навчальних дисциплін програми підготовки майбутніх економістів в університетах, під час вивчення яких можуть бути сформовані навички саме цифрової безпеки. На прикладі одного з компонентів навичок цифрового інтелекту, а саме цифрової безпеки, продемонстровано етапи формування, індикатори для різних рівнів сформованості, зміст та приклади подання навчальних матеріалів. Визначено набір різних типів ресурсів і сервісів гібридного хмаро орієнтованого середовища університету, які важливо використовувати для ефективної підготовки майбутніх економістів, а саме: сервіси для цифрової безпеки (безпека мереж; безпека програм; безпека вебдодатків); електронні ресурси (навчальний портал; МВОКи; фахові інтернет-ресурси), середовища для спільної роботи (сервіси для комунікації; сервіси для співпраці; сервіси для кооперації), сервіси для управління, обліку та бізнес-аналізу (системи для управління; системи для обліку; системи для бізнес-аналізу). Запропоновано етапність формування та розвитку навичок з цифрової безпеки в межах вивчення модуля «Цифрова безпека: захист у цифровому середовищі» та виконання проєктної роботи в межах вивчення навчальної дисципліни «Інформаційні системи і технології в економіці», розв’язування реальної практичної ситуації під час навчальної практики. Наведено також результати експериментального дослідження для досягнення усіх трьох рівнів сформованості з цифрової безпеки як складової цифрового інтелекту майбутнього економіста. Здійснено статистичний аналіз результатів експерименту та доведено його значущість.
Identificação e cálculos de parâmetros de soldagem aplicados a pontes ferroviárias
Authors: Silva Camila Ferreira da , Medeiros Ronaldo Gomes de Castro , Freitas Patricia Guimarães Monteiro de , Sousa Nathália de Paula , Zenóbio Isadora Rapoza
Published: May 2021

Pontes ferroviárias são elementos chave no cenário do transporte mundial, apresentando uma variedade de aplicações possíveis. Entretanto, faz-se necessário averiguar o desempenho da sua estrutura a fim de prevenir danos em termos de projeto, pois caso o projeto seja aplica sem que haja uma verificação de sua estrutura e seus componentes pode-se ocorrer acidentes indesejáveis. Os parâmetros essenciais a serem investigados são o teor de carbono equivalente do aço (CEq), a Temperatura de Pré Aquecimento (TPA), a Energia Liquida de Soldagem (Hl) e o processo de soldagem em si, uma vez que os mesmos influenciam nas propriedades mecânicas do material. Este artigo aborda a determinação dos parâmetros de soldagem para uma ponte ferroviária, sendo estes obtidos a partir da composição química do aço estrutural da ponte. Determina-se ainda questões de dimensionamento, tonelagem e a escolha do processo de soldagem ideal para um projeto de grande magnitude, exemplificando procedimentos técnicos inerentes à construção.
Simulation of transport and persistence of carbamate aldicarb in soil columns
Authors: Orlanda José Fábio França , Jacinto Flávia Emília , Neves Antônio Augusto , Queiroz Maria Eliana Lopes Ribeiro de
Published: May 2021

This study evaluated the mobility and persistence of aldicarb and its degradation products in red-yellow oxisol (LVA) using soil columns, after the application of Temik 150. Leaching experiments were performed using polyvinyl chloride (PVC) columns filled with soil contaminated with aldicarb and rain simulation of 6.05 mm day-1, at 10 day intervals, for 90 days. Aldicarb, aldicarb sulfoxide and aldicarb sulfone residues were extracted from soil (solid-liquid) and percolated water (liquid-liquid) samples with quantification by CG-FID. The results showed that aldicarb was rapidly oxidized to aldicarb sulfoxide and aldicarb sulfone in 10 days after the application. Aldicarb sulfoxide percolated through 15 cm of the soil column and could not be detected in the soil after 40 days incubation. From the 60 days since application, residues were no longer detected in the samples of percolated water and soil fractions, indicating rapid degradation and low potential for groundwater contamination.
Prevalência de lesões psicossomáticas na cavidade bucal em policiais militares do Estado de Alagoas
Authors: Silva Iris Marilia Alves da , Melo Érika Priscila Santos , Borges Larissa de Oliveira Carvalho , Silva Josimeire Barbosa , Santos Luiz Carlos Oliveira dos
Published: May 2021

O presente artigo aborda um levantamento da prevalência de doenças psicossomáticas com repercussão na cavidade bucal em indivíduos que demandam da Polícia Militar de Alagoas (PMAL). A pesquisa teve como objetivo identificar a frequência destas lesões em policiais militares pertencentes ao 1º Batalhão da PMAL, relacionando-as a fatores como faixa etária, gênero, atividade profissional e patente. A hipótese levantada foi de que o estresse no trabalho pode contribuir para o surgimento de lesões bucais psicossomáticas nos policiais da PMAL. Trata-se de um estudo transversal analítico com abordagem quantitativa e qualitativa em pacientes que demandam do 1º Batalhão da Polícia Militar de Alagoas. A metodologia empregada baseou-se em entrevista seguida de exame clínico da cavidade bucal em cada um dos policiais incluídos na pesquisa e fundamentou-se em uma revisão bibliográfica acerca do assunto. Foram detectados através dos exames e relatos dos pacientes casos de ulceração aftosa recorrente, herpes labial, bruxismo, xerostomia, mucosa mordiscata e língua geográfica. Os estudos apontam uma prevalência de lesões similar ao observado na população em geral, não havendo diferenças significativas com relação a gênero, faixa etária, patente e atividade profissional. Ressalta-se a importância do correto diagnóstico de lesões na cavidade bucal com o propósito de orientar, tratar e proporcionar melhor qualidade de vida aos pacientes.
Capacidade de autodepuração em ambiente lótico a partir do modelo matemático de Streeter-Phelps no nordeste paraense
Authors: Pereira Junior Antonio , Miranda Ayla Fernandes Muniz , Barros Estefani Danielle de Araujo , Sardinha Aline Souza
Published: May 2021

O município de Capanema - PA, se desenvolveu às margens do rio Ouricuri. Em face disso, é importante o conhecimento da capacidade de autodepuração desse recurso hídrico. O objetivo desta pesquisa foi analisar quantiqualitativamente, a simulação da capacidade de autodepuração desse ambiente lótico, e propor duas medidas mitigatórias para a redução dos impactos gerados no corpo hídrico e melhorias na qualidade da água. O método foi dedutivo, abrangência quantiqualitativa e natureza aplicada. Os dados obtidos e analisados, para os três pontos, P1, P2 e P3, no período chuvoso: para o Rio Ouricuri foram, OD:  = 0,26 mg/L; DBO5:  = 10 mg/L; vazão:  = 1,80 m³/s; temperatura:  = 26 ºC, para a anilha de efluentes: OD:  = 0,16 mg/L, DBO5:  = 300 mg/L; vazão: 0,88 m³/s; temperatura:  = 26 ºC. No período seco, para o Rio Ouricuri: OD:  = 0,16 mg/L; DBO5:  = 10 mg/L; vazão:  = 0,93 mg/L; e temperatura:  = 25 ºC; para a anilha de efluentes: OD:  = 0,43 mg/L, DBO5:  = 300 mg/L, vazão:  = 0,88 m³/s e temperatura:  = 27 °C. Comparam-se os valores de OD, e DBO com a Resolução CONAMA 357/05, e verificou-se que estão em não conformidade, logo, o rio é considerado poluído tanto para potabilidade quanto para balneabilidade. Portanto, é necessário que os órgãos responsáveis no município utilizem dos dados aqui contidos para elaboração de medidas mitigatórias para a recuperação do rio.
Unusual Ludwig´s angina in systemic disabled patient related with periodontal disease
Authors: Hadad Henrique , Jesus Laís Kawamata de , Santos Ana Flávia Piquera , Colombo Luara Teixeira , Silva Nelson Padilha , Rodrigues Letícia Gabriella de Souza , Mendes Kezia Barbosa , Santos Gabriel Mulinari dos , Oliveira Gustavo Augusto Grossi de , Martins Everton Pontes , Fabris André Luiz da Silva , Aranega Alessandra Marcondes , Bassi Ana Paula Farnezi , Ponzoni Daniela , Faverani Leonardo Perez , Filho Osvaldo Magro , Garcia Júnior Idelmo Rangel , Souza Francisley Ávila
Published: May 2021

The Ludwig's angina is an infectious process involving submandibular, sublingual, and submental spaces bilaterally. They can rapidly progress to airway obstruction and hemodynamic instability. The most common cause of Ludwig's angina is apical dental infections, specifically involving the roots of second and third mandibular molars, which are contiguous to the submandibular space. Periodontal diseases are related with bone loss around dental roots and create a situation where the inflammatory drainage tends to assume a sulcular direction. The purpose of this article is to report a clinical patient with an unusual development of a periodontic-endodontic lesion leading to Ludwig's angina in patient whit diabetics, hypertension and chronic kidney disease. Thus, we can conclude that even if it is not common reports of angina associated with periodontal diseases we must attend to patient's correct care, initiating antibiotic therapy, maintenance of the airways, removal of infectious focus and control of comorbidities diseases.
THE VALUE RELEVANCE OF ENVIRONMENTAL PERFORMANCE, CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE, AND RETURN ON EQUITY
Authors:   Universitas Ciputra Surabaya Indonesia, Gunardi Ega Jenny , Widianingsih Luky Patricia ,   Universitas Ciputra Surabaya Indonesia, Ismawati Anastasia Filiana ,   Universitas Ciputra Surabaya Indonesia
Published: May 2021

This study aims to examine the value relevance of green accounting practice measured by environmental rating through PROPER which is assessed by the Ministry of Environment and Forestry (KLHK) and environmental disclosure activities from an internal party, called sustainability report, of listed mining and agriculture companies on the Indonesian Stock Exchange. This study also tests whether return on equity can strengthen the value relevance of environmental performance and CSR disclosure. The sample consists of 63 firm-year observations. The empirical results showed that the effect of book value of equity and earnings on share price are significant. The study reveals book value of equity exhibits a negative relationship in stock price, while earnings exhibit a negative relationship. However, environmental performance and CSR disclosure are found not statistically significant impact in terms of share price, which conclude they don’t have value relevance. The study also found that ROE hasn’t succeeded to strengthen the value relevance of environmental performance and CSR disclosure.
Kebijakan Dividen Pada Perusahaan Sektor Industri Barang Konsumsi di Indonesia: Kebijakan Utang, Profitabilitas, Likuiditas
Authors: Firmansyah Amrie , Asikin Nurlatifah , Gultom Samtri Dortua
Published: May 2021

Penelitian ini bertujuan untuk menginvestigasi pengaruh kebijakan utang, profitabilitas, dan likuiditas terhadap kebijakan dividen.  Penelitian ini menggunakan data sekunder yang bersumber dari laporan keuangan tahunan perusahaan sektor Barang Konsumsi yang tercatat di Bursa Efek Indonesia (BEI) periode 2017-2019. Sumber data berupa laporan keuangan diperoleh dari website resmi Bursa Efek Indonesia dengan laman http://www.idx.co.id. Berdasarkan purposive sampling telah dilakukan, total sampel yang digunakan dalam penelitian ini berjumlah 63 observasi. Pengujian hipotesis menggunakan regresi data panel. Hasil pengujian menunjukkan bahwa kebijakan utang, profitabilitas, dan likuiditas tidak berpengaruh terhadap kebijakan dividen. Oleh karena itu, informasi dari ketiga variabel tersebut tidak dapat digunakan sebagai sinyal dalam memprediksi kebijakan dividen perusahaan. Penelitian ini mengindikasikan bahwa informasi atas tingkat utang, laba rugi, dan jumlah kas dalam laporan keuangan tidak digunakan oleh investor dalam menilai kebijakan dividen perusahaan.
Pengaruh Leverage, Profitabilitas dan Likuiditas Terhadap Nilai Perusahaan Pada Perusahaan Pertambangan Periode Tahun 2015- 2017
Authors: Kurniawan Kurniawan , Mulyanta Suharto
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh leverage yang diukur menggunakan Debt to Equity Ratio (DER), profitabilitas yang diukur dengan menggunakan Return On Assets (ROA) dan Return on Equity (ROE) dan likuiditas yang diukur dengan menggunakan Current Ratio terhadap nilai perusahaan yang diukur menggunakan price to book value (PBV) pada perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2015-2017. Jenis penelitian ini adalah penelitian kausal dengan teknik pengambilan sampel menggunakan teknik purposive sampling. Hasil dari penelitian ini diharapkan memberikan kontribusi, referensi informasi dan bukti empiris yang dibutuhkan untuk pihak yang membutuhkan terakit leverage, profitabilitas, dan likuiditas dan hubungannya dengan nilai perusahaan.
Swift-Hohenberg Model of Liquid Artificial Humans Mimicking Human Graded Reactions
Authors: Frank T. D. , Pereira A.
Published: May 2021

Humans and liquid systems have in common that they are both complex, self-organizing systems that produce under certain circumstances spatio-temporal patterns. The current study exploits this cross-disciplinary point of view and studies human graded reactions in terms of continuous confidence ratings from a pattern formation perspective. The wellknown V-shaped ratings are modelled by means of amplitude equations that are generic for a plenitude of pattern formation systems. Experimental data from three independent research groups are shown to fit simple, two-parametric amplitude equation models with goodness of fit measures of 90 percent. Importantly, the Swift-Hohenberg model describing the emergence of roll patterns in liquids is solved to show that under appropriate conditions the amplitudes of emerging roll patterns produce the same type of V-shaped functions as observed in humans. A new research avenue is opened for liquid artificial humans in terms of liquid systems that mimic human reactions.
Hermiticity and Self-Adjointness in Quantum Mechanics
Authors: Silenko Alexander J.
Published: May 2021

Hamiltonians in the geveralized Feshbach-Villars and Foldy-Wouthuysen representations describing an interaction of a scalar particle with electromagnetic fields in the Minkowski spacetime are self-adjoint and Hermitian (or pseudo-Hermitian) when they are presented in terms of operators of covariant derivatives. When one uses curvilinear coordinates in special relativity, the transition to the canonical momentum operator does not change these properties. When the curvilinear coordinates are applied in general relativity, the corresponding transition to the canonical momentum operator leads to the seeming non- Hermiticity of the Hamiltonians. Since the Hamiltonians remain in fact Hermitian, this seeming non-Hermiticity should not be eliminated by any nonunitary transformation.
A Modern History of the Not Proven Verdict
Authors: Chalmers James , Leverick Fiona , Munro Vanessa E
Published: May 2021

While the origins of Scots law's unique “not proven” verdict in criminal cases are well-documented, there has been no systematic examination of its use and interpretation over time. Although the verdict has frequently been the subject of controversy in the courts, legal journals or public debate, analysis of it has tended to be sporadic and focused on specific controversies arising at given points in time. As a result, discussions about the verdict's future are often cyclical, meaning that the debate tends to repeat itself rather than advancing over time. This article fills this gap in the literature. Based on a comprehensive review of sources including (but not limited to) judicial statistics, court decisions, periodical literature and Parliamentary debates, it charts the evidence on the use of the not proven verdict by juries, the approach of the courts, and debates both on how the verdict should be interpreted and whether it should be retained.
Taguchi Method and Taguchi-Pareto Scheme to Evaluate Diffusivity during the Development of Orange Peel Epoxy Composites
Authors: Ajibade Oluwaseyi Ayodele , Agunsoye Johnson Olumuyiwa , Oke Sunday
Published: May 2021

The diffusion parameters of orange peel epoxy composites are important elements in composite structure in that they explain how fast water and other fluids can diffuse through the composites as a sign of integrity test. In this article, we defined the optimal parametric settings for diffusivity parameters of orange peel epoxy composites. The Taguchi optimisation method used obtained an optimal parametric setting of P4Q4R1 in experiments conducted for three and seven days, respectively. The analysis of variance revealed significant contributions made by the initial and final weights, while the thickness parameter was found to be less significant. A variant of the Taguchi method called Taguchi-Pareto was introduced, which also underscores the thickness parameter as not economical to optimality. The specifications and dimensions obtained by Taguchi method or its variant may be useful design engineers when contemplating on how to reduce diffusivity and water uptake of composites.
Optimisation of Water Absorption Parameters of Bagasse, Cocoa Pod Husk and Guinea Fowl Feather Reinforced Hybrid Epoxy Composites using Taguchi Method
Authors: Ayanladun Chris Abiodun , Oke Sunday Ayoola
Published: May 2021

Particulate waste of bagasse, cocoa pod husk and guinea fowl feathers may be adopted to fabricate epoxy composites due to their properties of biodegradability, lightweight and cheapness. However, most research has excluded the combination of these reinforcements while the optimisation behaviour of the reinforced composites at room temperature water absorption process is not known. To fill this knowledge gap, this paper aims to analyse issues related to optimisation of the mentioned reinforced composites considering Taguchi’s L25 orthogonal array, the smaller the better signal-to-noise criterion and remodelling of signal-to-noise ratio after the exponential smoothening structure for optimisation. The experiment considered 25% reinforcement blends to 75% epoxy resin. But the 25% reinforcement had five formulations among the component reinforcements. The experiment, using tap water, was conducted for 216 days with measurement intervals random. The response table yielded A5B5C4, indicating 158 experimental days, 12.29g of weight gained by the drained composites, and 7.32g of weight gained by composites damped in 190ml of water. The revised response table that has been influenced by the exponential smoothening method yielded A5B5C5, interpreted as 158 days of experiments, 12.29g of weight gained by the drained composites, and 7.44g of weight gained by composites dumped in 190ml of water. Using the damping factors from 0.05 to 1, different combinations as optimal parameters were obtained, assuring the investigator that the method is feasible. Thus, the optimisation assessment could provide a new method of combining the reinforcement to enhance the composite development process using waste.
Preparation and Characterization of Polymer based Electrolytes for Dye-sensitized Solar Cell Application
Authors: I Chowdhury Faisal , Hossain M. Zabed , Buraidah M. H. , A. K. Arof  , Jahidul Islam  , Rahman M. Rezaur , Uddin Jamal
Published: May 2021

A gel-type polymer electrolyte (GPE) composite based on polyacrylonitrile (PAN) conducting polymer plasticized with ethylene carbonate (EC) and propylene carbonate (PC) doped by different compositions of tetrapentylammonium iodide (TPeAI) salt has been prepared and investigated. Electrochemical impedance spectroscopy (EIS) and linear sweep voltammetry (LSV) techniques have been used to characterize the prepared GPEs. From the EIS study, it has been observed that 30 wt % TPeAIcontaining GPE has the lowest bulk impedance, Rb (32 ohm) and highest room-temperature ionic conductivity (2.4910-3 S cm-1). The conductivity vs temperature diagram in the range of studied temperature studied follows the Arrhenius rule. The values of activation energies, (Ea) are observed to decrease with the increase of the percentage of TPeAI percentage with the lowest values (8.50105 J/mol) for 30% TPeAI containing GPE. From LSV graphs for the GPE systems, various parameters such as the limiting current density (Jlim), the apparent diffusion coefficient of triiodide ion () and exchange current density (J0) have been estimated. The most conducting GPE material shows the highest values of Jlim (3.95 mA.cm-2),  (7.86×10-8cm2 s-1) and J0 (0.46 mA.cm-2). The GPEs will be suitable for application in Dye-sensitized Solar Cell (DSSC).
PENILAIAN ORGANOLEPTIK DAN KARAKTERISTIK FISIK COOKIES TEPUNG UBI KANO (Dioscorea rotundata) FERMENTASI BAKTERI ASAM LAKTAT ISOLAT SBM.4A
Authors: Zikirah Sitti , Wahyuni Sri , Susilowati Prima Endang
Published: May 2021

ABSTRACTOne effort to reduce dependence on wheat flour is by utilizing local food in several regions in Indonesia, one of which is Wakatobi, Southeast Sulawesi. Kano can be processed to make cookies because it has a high potential as a carbohydrate source. However, several physicochemical properties must be improved to produce the flour with better characteristics. One way that can be done to modify starch is by fermentation using LAB. This study aimed to analyze the effect of LAB fermentation on the organoleptic assessment and physical characteristics of cookies. The result of the research on the organoleptic test of fermented kano potato flour cookies was 3.20 (slightly like) and unfermented kano sweet potato flour cookies was 4.20 (like).Keywords: Kano’s flour, Modification, CookiesABSTRAKSalah satu upaya untuk mengurangi ketergantungan tepung terigu yaitu dengan memanfaatkan pangan lokal pada beberapa daerah di Indonesia, salah satunya di Wakatobi Sulawesi Tenggara.Ubi kano dapat diolah dalam pembuatan cookies, karena berpotensi sebagai sumber karbohidrat yang cukup tinggi. Namun, ada beberapa sifat fisikokimia yang harus diperbaiki agar dapat memperbaiki karakteristik tepung yang dihasilkan. Salah satu cara yang dapat dilakukan untuk modifikasi pati adalah dengan fermentasi menggunakan BAL. Penelitian ini bertujuan untuk menganalisis pengaruh fermentasi BAL pada penilaian organoleptik dan karakteristik fisik cookies. Hasil penelitian uji organoleptik cookies tepung ubi kano fermentasi secara overall 3,20 (agak suka) dan cookies tepung ubi kano tanpa fermentasi 4,20 (suka).Kata kunci : Tepung ubi kano, Modifikasi, Cookies
FEATURES OF ERGONOMIC EVALUATION OF MANUAL POWER TOOLS
Authors:   Bilotserkivsky Institute of Continuous Professional Education, Borodina Nataliiа , Cheberiachko Serhii ,   Dnipro University of Technology, Deryugin Oleg ,   Dnipro University of Technology, Tretyak Olena ,   Dnipro University of Technology
Published: May 2021

Hand-held power tools are an integral part of any manufacturing process. Modern power tools are characterized by operational, consumer, ergonomic and safety properties. These properties characterize its effective adaptability to the relevant production process. But it should also be noted that not taking into account the ergonomic properties: noise load, vibration, tool weight, heating temperature of the working surface of the tool, etc. causes very serious consequences for the deterioration of the health of the employee who uses it. This is especially true for occupational diseases of the circulatory system, nervous system, diseases of the bone and vascular tissue. Object of the study – development of a fast-effective method for assessing the ergonomic risk of hand-held power tools when performing a specific production task Purpose of the study – ergonomic risk when working with hand tools when performing the appropriate technological process. Method of the study – the research method is based on observations and studies of specific phenomena of the process under consideration, as well as the generalization of the results of experimental research and their implementation in practice. Results of the study – the most influential criteria that affect employee productivity when working with hand tools are identified: integrated design ergonomics, load, tool weight, jerk load, tool surface heating temperature, vibration, noise, dust particles during tool operation. For each criterion the corresponding estimation of ergonomic risk taking into account influence on a physical, psychological condition of the worker is proved. A checklist has been developed to determine the level of ergonomic risk according to eight criteria. Keywords: hand power tools, ergonomic risk, indicator, harmful factors, occupational diseases, checklist.
DEFINITION AND MEASUREMENT QUALITY CRITERIAS OF PUBLIC PASSENGER TRANSPORT SERVICE ACORDING TO THE EUROPEAN UNION EXPERIENCE
Authors:   SE «State Road Transport Research Institute», Novikova Alla , Velisevich Mykola ,   SE «State Road Transport Research Institute», Pospishna Olga ,   SE «State Road Transport Research Institute»
Published: May 2021

The article outlines possible ways to solve the scientific and applied problem of defining and measuring the quality criteria of public passenger transport services, taking into account the European Union experience. The main method of achievment this goal is the development and implementation national standards for defining quality criteria for passenger transport services and their measurement systems. They are based on identical translations two European standards: EN 15140:2006 and EN 13816:2002. Standarts provide the definition eight main criterias of service quality and three main methods of measuring these criterias. The paper presents examples of measuring certain criterias. These standards are intended for using by all modes of land transport (road, rail, urban electric and subway). The relevant parts of these standards have be used during designing appropriate systems for a particular mode of transport, The basic scheme of actions concerning management of quality of services of public passenger transport is developed. Extended examples of methods for measuring the quality of public passenger transport services are provided. The practical significance of the results are: national quality standards will be allowed; clear rules of framework agreements the public procurement procedure for transport services are established; the quality of transport services will improved. This is especially important in the context of the administrative-territorial reform Ukraine, when the bus route network changes. Keywords: measurement of service quality, public passenger transport, satisfaction of consumer needs, standarts, passenger transport services.
Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver
Authors: Herthum Helge , Shahryari Mehrgan , Tzschätzsch Heiko , Schrank Felix , Warmuth Carsten , Görner Steffen , Hetzer Stefan , Neubauer Hennes , Pfeuffer Josef , Braun Jürgen , Sack Ingolf
Published: May 2021

Modulation of cerebral blood flow and vascular compliance plays an important role in the regulation of intracranial pressure (ICP) and also influences the viscoelastic properties of brain tissue. Therefore, magnetic resonance elastography (MRE), the gold standard for measuringin vivoviscoelasticity of brain tissue, is potentially sensitive to cerebral autoregulation. In this study, we developed a multifrequency MMRE technique that provides serial maps of viscoelasticity at a frame rate of nearly 6 Hz without gating, i.e., in quasi-real time (rt-MMRE). This novel method was used to monitor rapid changes in the viscoelastic properties of the brains of 17 volunteers performing the Valsalva maneuver (VM). rt-MMRE continuously sampled externally induced vibrations comprising three frequencies of 30.03, 30.91, and 31.8 Hz were over 90 s using a steady-state, spiral-readout gradient-echo sequence. Data were processed by multifrequency dual elasto-visco (MDEV) inversion to generate maps of magnitude shear modulus | G∗| (stiffness) and loss angle φ at a frame rate of 5.4 Hz. As controls, the volunteers were examined to study the effects of breath-hold following deep inspiration and breath-hold following expiration. We observed that | G∗| increased while φ decreased due to VM and, less markedly, due to breath-hold in inspiration. Group mean VM values showed an early overshoot of | G∗| 2.4 ± 1.2 s after the onset of the maneuver with peak values of 6.7 ± 4.1% above baseline, followed by a continuous increase in stiffness during VM. A second overshoot of | G∗| occurred 5.5 ± 2.0 s after the end of VM with peak values of 7.4 ± 2.8% above baseline, followed by 25-s sustained recovery until the end of image acquisition. φ was constantly reduced by approximately 2% during the entire VM without noticeable peak values. This is the first report of viscoelasticity changes in brain tissue induced by physiological maneuvers known to alter ICP and detected by clinically applicable rt-MMRE. Our results show that apnea and VM slightly alter brain properties toward a more rigid-solid behavior. Overshooting stiffening reactions seconds after onset and end of VM reveal rapid autoregulatory processes of brain tissue viscoelasticity.
N-Terminus of GRXCR2 Interacts With CLIC5 and Is Essential for Auditory Perception
Authors: Li Jinan , Liu Chang , Zhao Bo
Published: May 2021

Stereocilia of cochlear hair cells are specialized mechanosensing organelles that convert sound-induced vibration to electrical signals. Glutaredoxin domain-containing cysteine-rich protein 2 (GRXCR2) is localized at the base of stereocilia and is necessary for stereocilia morphogenesis and auditory perception. However, the detailed functions of GRXCR2 in hair cells are still largely unknown. Here, we report that GRXCR2 interacts with chloride intracellular channel protein 5 (CLIC5) which is also localized at the base of stereocilia and required for normal hearing in human and mouse. Immunolocalization analyses suggest that GRXCR2 is not required for the localization of CLIC5 to the stereociliary base during development, or vice versa. Using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, we deleted 60 amino acids near the N-terminus of GRXCR2 essential for its interaction with CLIC5. Interestingly, mice harboring this in-frame deletion in Grxcr2 exhibit moderate hearing loss at lower frequencies and severe hearing loss at higher frequencies although the morphogenesis of stereocilia is minimally affected. Thus, our findings reveal that the interaction between GRXCR2 and CLIC5 is crucial for normal hearing.
Manufacture and Prebiotic Potential of Xylooligosaccharides Derived From Eucalyptus nitens Wood
Authors: Míguez Beatriz , Gullón Patricia , Cotos-Yáñez Tomás , Massot-Cladera Malén , Pérez-Cano Francisco José , Vila Carlos , Alonso José Luis
Published: May 2021

Mixtures of xylooligosaccharides (XOS) were manufactured from Eucalyptus nitens samples by hydrothermal processing. In order to obtain a product suitable to be used as a prebiotic, the liquors obtained were subjected to a refining sequence consisting of a two-step membrane filtration followed by anion exchange and freeze-drying. The process proposed allowed to obtain a highly refined product mainly made up of a mixture of substituted XOS with a degree of polymerization, DP3–10, which was evaluated for its prebiotic potential by in vitro fermentation assays. Their effects on the microbiota composition and the metabolic activity were assessed along the fermentation time and compared to fructooligosaccharides (FOS, a gold standard prebiotic), using fecal inocula from donors belonging to two age-groups (young and elderly). Significant and similar increases were observed in most of the bacterial groups considered (including Bifidobacterium spp. or several butyrate-producers) in both XOS and FOS in vitro interventions, although XOS resulted in significantly higher increases in total bacteria and lower rises in Clostridium clusters I and II than FOS. Regarding the metabolic activity, higher amounts of total organic acid (TOA; 150 vs. 110 mM) and higher total short-chain fatty acid (SCFA)/TOA ratio (0.88 vs. 0.70 mol/mol) were achieved at 28 h using XOS as a carbon source in comparison with FOS. Moreover, both substrates resulted in different metabolite profiles. Higher percentages of acetate and propionate were achieved when XOS were used as substrates, whereas FOS resulted in slightly higher concentrations of butyrate. No differences were found between both age-groups. Taking together these results, it can be concluded that XOS produced from E. nitens by a biorefinery-based approach led to, at least, similar prebiotic activity as that observed with FOS.
iMAP: A Web Server for Metabolomics Data Integrative Analysis
Authors: Zhou Di , Zhu Wenjia , Sun Tao , Wang Yang , Chi Yi , Chen Tianlu , Lin Jingchao
Published: May 2021

Metabolomics data analysis depends on the utilization of bioinformatics tools. To meet the evolving needs of metabolomics research, several integrated platforms have been developed. Our group has developed a desktop platform IP4M (integrated Platform for Metabolomics Data Analysis) which allows users to perform a nearly complete metabolomics data analysis in one-stop. With the extensive usage of IP4M, more and more demands were raised from users worldwide for a web version and a more customized workflow. Thus, iMAP (integrated Metabolomics Analysis Platform) was developed with extended functions, improved performances, and redesigned structures. Compared with existing platforms, iMAP has more methods and usage modes. A new module was developed with an automatic pipeline for train-test set separation, feature selection, and predictive model construction and validation. A new module was incorporated with sufficient editable parameters for network construction, visualization, and analysis. Moreover, plenty of plotting tools have been upgraded for highly customized publication-ready figures. Overall, iMAP is a good alternative tool with complementary functions to existing metabolomics data analysis platforms. iMAP is freely available for academic usage at https://imap.metaboprofile.cloud/ (License MPL 2.0).
Metabolism and Chronic Inflammation: The Links Between Chronic Heart Failure and Comorbidities
Authors: Li Zhiwei , Zhao Hongmei , Wang Jing
Published: May 2021

Heart failure (HF) patients often suffer from multiple comorbidities, such as diabetes, atrial fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease. The coexistance of comorbidities usually leads to multi morbidity and poor prognosis. Treatments for HF patients with multi morbidity are still an unmet clinical need, and finding an effective therapy strategy is of great value. HF can lead to comorbidity, and in return, comorbidity may promote the progression of HF, creating a vicious cycle. This reciprocal correlation indicates there may be some common causes and biological mechanisms. Metabolism remodeling and chronic inflammation play a vital role in the pathophysiological processes of HF and comorbidities, indicating metabolism and inflammation may be the links between HF and comorbidities. In this review, we comprehensively discuss the major underlying mechanisms and therapeutic implications for comorbidities of HF. We first summarize the potential role of metabolism and inflammation in HF. Then, we give an overview of the linkage between common comorbidities and HF, from the perspective of epidemiological evidence to the underlying metabolism and inflammation mechanisms. Moreover, with the help of bioinformatics, we summarize the shared risk factors, signal pathways, and therapeutic targets between HF and comorbidities. Metabolic syndrome, aging, deleterious lifestyles (sedentary behavior, poor dietary patterns, smoking, etc.), and other risk factors common to HF and comorbidities are all associated with common mechanisms. Impaired mitochondrial biogenesis, autophagy, insulin resistance, and oxidative stress, are among the major mechanisms of both HF and comorbidities. Gene enrichment analysis showed the PI3K/AKT pathway may probably play a central role in multi morbidity. Additionally, drug targets common to HF and several common comorbidities were found by network analysis. Such analysis has already been instrumental in drug repurposing to treat HF and comorbidity. And the result suggests sodium-glucose transporter-2 (SGLT-2) inhibitors, IL-1β inhibitors, and metformin may be promising drugs for repurposing to treat multi morbidity. We propose that targeting the metabolic and inflammatory pathways that are common to HF and comorbidities may provide a promising therapeutic strategy.
Requirements for a Robust Animal Model to Investigate the Disease Mechanism of Autoimmune Complications Associated With ARF/RHD
Authors: Rafeek Rukshan A. M. , Sikder Suchandan , Hamlin Adam S. , Andronicos Nicholas M. , McMillan David J. , Sriprakash Kadaba S. , Ketheesan Natkunam
Published: May 2021

The pathogenesis of Acute Rheumatic Fever/Rheumatic Heart Disease (ARF/RHD) and associated neurobehavioral complications including Sydenham's chorea (SC) is complex. Disease complications triggered by Group A streptococcal (GAS) infection are confined to human and determining the early events leading to pathology requires a robust animal model that reflects the hallmark features of the disease. However, modeling these conditions in a laboratory animal, of a uniquely human disease is challenging. Animal models including cattle, sheep, pig, dog, cat, guinea pigs rats and mice have been used extensively to dissect molecular mechanisms of the autoimmune inflammatory responses in ARF/RHD. Despite the characteristic limitations of some animal models, several rodent models have significantly contributed to better understanding of the fundamental mechanisms underpinning features of ARF/RHD. In the Lewis rat autoimmune valvulitis model the development of myocarditis and valvulitis with the infiltration of mononuclear cells along with generation of antibodies that cross-react with cardiac tissue proteins following exposure to GAS antigens were found to be similar to ARF/RHD. We have recently shown that Lewis rats injected with recombinant GAS antigens simultaneously developed cardiac and neurobehavioral changes. Since ARF/RHD is multifactorial in origin, an animal model which exhibit the characteristics of several of the cardinal diagnostic criteria observed in ARF/RHD, would be advantageous to determine the early immune responses to facilitate biomarker discovery as well as provide a suitable model to evaluate treatment options, safety and efficacy of vaccine candidates. This review focuses on some of the common small animals and their advantages and limitations.
Low-Level Stimulation and Ethanol Ablation of the Vein of Marshall Prevent the Vagal-Mediated AF
Authors: Liu Fei , Sun Wei , Li Yan , Sun Yuanjun , Yu Xiaohong , Yin Xiaomeng , Xia Yunlong
Published: May 2021

Background: The mechanisms for the vein of Marshall (VOM) mediated atrial fibrillation (AF) are not completely understood. We sought to evaluate the contribution of the intrinsic cardiac autonomic nervous system in VOM mediated AF.

Method: Seven mongrel dogs were administered propranolol and continuously exposed to left superior ganglionated plexi (LSGP) stimulation, LSGP + low-level VOM stimulation, LSGP + atropine administration, LSGP + VOM filling with ethanol separately. The effective refractory period (ERP) and window of vulnerability (WOV) at the left superior pulmonary vein (LSPV), left inferior pulmonary vein (LIPV) and left atrial appendage (LAA) were measured.

Result: LSGP stimulation significantly shortens the ERP and prolonged the ERP dispersion and WOV in LSPV, LIPV, and LAA. Interestingly, low-level VOM stimulation, atropine administration, or VOM filling with ethanol were able to attenuate the effects of LSGP in all sites.

Conclusion: VOM as an inter-communication pathway of ganglionated plexis plays an important role in the development of vagal-related AF.
Review of Animal Models to Study Pulp Inflammation
Authors: Aubeux Davy , Renard Emmanuelle , Pérez Fabienne , Tessier Solène , Geoffroy Valérie , Gaudin Alexis
Published: May 2021

Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells that play a major role in the defense against pathogens and during tissue injury. Animal studies are mandatory and complementary to in vitro experiments when studying the physiopathology of dental pulp, new diagnostic tools, or innovative therapeutic strategies. This animal approach makes it possible to define a benefit-risk ratio necessary to be subsequently tested in humans. Among the animal kingdom, rodents, rabbits, ferrets, swine, dogs, and non-human primates have been used to model human pulpitis. The diversity of animals found in studies indicate the difficulty of choosing the correct and most efficient model. Each animal model has its own characteristics that may be advantageous or limiting, according to the studied parameters. These elements have to be considered in preclinical studies. This article aims to provide a thorough understanding of the different animal models used to study pulp inflammation. This may help to find the most pertinent or appropriate animal model depending on the hypothesis investigated and the expected results.