bluuebunny/crossref_metadata_2025 huggingface dataset:
Perception of Cigarette Graphic Health Warnings and Its Impact on Smoking Behavior: A Cross-Sectional Study among Current Smokers of Western Part of Nepal
Authors: Shrestha Santosh , Pokhrel Santosh , Subedi Suraj , Paudel Hemraj , Viswakarma Rup Chandra , Poudel Diptee , Bhattarai Shiva Lal , Bhandari Puja , Kuikel Sandip , Ward Kenneth
Published: September 2022

Globally, tobacco use (smoked, secondhand, and chewing) accounted for 8.71 million deaths, which is 15.4% of all deaths in 2019. Tobacco was ranked first among males and sixth among female in terms of level 2 risk factor for attributable deaths globally. The objective of this study was to identify the perception of cigarette graphic health warnings and their impact on smoking behavior in Nepal. A cross-sectional study using purposive sampling technique was done. Out of 169 respondents, 79.9% were male, 49.1% were illiterate, and 37.9% were above 60 years of age. Eighty-four percent had initiated smoking before the age of 20, and 39.6% had smoked cigarettes for more than 40 years. All the respondents had noticed the graphic health warning on cigarette packages. The majority (80.5%) of the respondents reported that the warning informs about specific health consequences of smoking, and the percentage of respondents believing that warning motivates smokers to quit smoking, encourages smokers to reduce the number of cigarettes smoked per day, and deters potential smokers from starting to smoke was 40.2%, 33.1%, and 30.8%, respectively. More than half of the respondents (50.9%) attempted to quit smoking because of the warning. The implementation of graphic health warnings had favorable perception from majority of smokers and positive impact on smoking behavior of the respondents. Further large-scale research on impact on smoking behavior through repeated cross-sectional studies can be future research priority.
One‐Put Ferula‐Mediated Synthesis of Biogenic Silver Nanoparticles with More Antimicrobial Effect and Promising Human Cell Biocompatibility
Authors: Gholami Ahmad , Mousavi Seyyed Mojtaba , Shomali Ali , Hashemi Seyyed Alireza , Abootalebi Seyedeh Narjes , Chiang Wei-Hung , Barzegar Alireza , Shokripoor Mansooreh , Zadeh Abdolali Mohaghegh
Published: September 2022

The biogenic synthesis of silver nanoparticles has recently attracted more attention to counter microbial resistance, which has been one of the medical concerns in the last decade. This research expresses the biogenic synthesis of silver nanoparticles utilizing Ferula assafoetida aqueous extract (Fer@AgNP) as a reducing and capping agent. The total parts of the plant were extracted from an aqueous solution (FerEX) and characterized using GC/MS apparatus. The Fer@AgNP and chemically synthesized silver nanoparticles (AgNPs) were characterized using UV‐vis, Fourier transform infrared (FTIR) spectroscopies, field emission‐scanning transmission electron microscopy, powder X‐ray diffraction analysis, and energy‐dispersive X‐ray spectroscopy. The impacts of nanoparticles and FerEX were evaluated against four pathogenic bacterial strains, including Staphylococcus aureus, Escherichia coli, Salmonella typhi, and Enterococcus faecalis, using the microdilution method. The biocompatibility of compounds was also evaluated on human cell line L‐929 using MTT and human blood cells using the hemolytic assay. The major compounds found in FerEX were sulfur‐containing compounds such as butyl disulfides (45.36%) and monoterpenes such as α‐pinene (25.66%), β‐pinene (16.31%), and ocimene (7.26%). The characterizations of materials confirmed the hexagonal structure of AgNPs. The sizes of cAgNP and Fer@AgNP were about 42.7 nm and 22.5 nm. The antimicrobial activity of Fer@AgNP was considerably developed and reached MIC values ranging from 10 to 50 μg/mL compared to AgNP, which showed MIC values ranging from 50 to 100 μg/mL. The biocompatibility assessment showed that the Fer@AgNP was improved compared to AgNP and had a minimal toxic impact on the normal fibroblast cell line. The Fer@AgNP also indicated outstanding compatibility with human RBCs. The results illustrated that biosynthesized Fer@AgNPs have improved antimicrobial efficacy against Gram‐negative and Gram‐positive pathogenic bacteria with promising biocompatibility and can be used as potential antibacterial agents.
Material Behaviour of Three Blade Propeller Using Metal Additive Manufacturing Techniques
Authors: Malladi Avinash , Karunakaran K. , Saravanan R. , Asres Yalew
Published: September 2022

The defects stored during the fusion of the laser with the metal powder bed determine the optimal performance of fatigue and lifelong disintegration of the formed metal components. The advantage of using recent technologies of prototyping is very much powerful in understanding the physical process. The current works provide the details of the same for a 3-blade propeller with its thermomechanical approach to identified parameters. The results provide the materials used and their behaviour with the parameters which conclude in prescribing the material for the various applications. The investigation aimed to optimize the position of the object (3-blade Propeller) and material for printing through simulation before it was printed. The material choices of aluminium AlSi10 Mg, stainless steel 17–4 and stainless steel 316L were considered. The ten different object positions were considered and ranked by the minimum support area required. The top and bottom-ranked positions were further investigated with three different materials, namely Aluminium AlSi10 Mg, atainless steel 17–4, and stainless steel 316L, in which the Rank 1 position, the material of Aluminium AlSi10 Mg exhibits the minimum of maximum displacement (2.348e-01 mm), plastic strain (0.05), and the Von Mises Stress (2.086e+02 MPa).
Analysis of Different Routes of Hysterectomy Based on a Prospective Algorithm and Their Complications in a Tertiary Care Institute
Authors: Panda Subrat , Das Ananya , Das Rituparna , Sharma Nalini , Shullai Wansalan , Jante Vinayak , Sharma Anusuya , Singh Kaushiki , Baruah Prateeti , Makakmayum Ruksana
Published: September 2022

Introduction. Hysterectomy is the most common gynaecological operation worldwide. The objective of the study is to analyze the various routes of hysterectomy and its complications when the decision of route is based on using a prospective algorithm tree. Methodology. It is an observational study to analyze the route of hysterectomy based on using a prospective algorithm. The decision tree is based on pelvic pathology, uterine size, vaginal access, pelvic adhesion, competency of the surgeon, choice of the patient, and complication of different routes of hysterectomy. Data were collected from preoperative, intraoperative, and postoperative records. Demographic factors, indications, routes of hysterectomy, and complications were recorded and analyzed by using SPSS software version 22. Observation. Among the malignant or suspected malignant pathology groups, TAH was performed in 89 cases and TLH was performed in 3 cases. Among the benign disease groups, VH was performed in 137(38.2%) cases, TAH was performed in 118(32.9%) cases, and TLH was performed in 104 (28.9%) cases. Operative time and a number of blood transfusions were significantly less with VH (

p

value < 0.0001 and 0.004) compared to abdominal and total laparoscopic hysterectomy. Postoperative complication such as fever was more with abdominal hysterectomy (

p

-value<0.00001) compared to VH and TLH. Vaginal discharge was more with VH and TLH compared to TAH (

p

value −0.004) and wound infection was more in the abdominal route (

p

value 0.001). Conclusion. The abdominal route was the route of choice for surgery in malignancy or suspected malignant pathology. In benign pathology, VH was the most common and preferable route of surgery. Complications were found to be minimal with vaginal hysterectomy.
LawRec: Automatic Recommendation of Legal Provisions Based on Legal Text Analysis
Authors: Zheng Min , Liu Bo , Sun Le
Published: September 2022

Smart court technologies are making full use of modern science to promote the modernization of the trial system and trial capabilities, for example, artificial intelligence, Internet of things, and cloud computing. The smart court technologies can improve the efficiency of case handling and achieving convenience for the people. Article recommendation is an important part of intelligent trial. For ordinary people without legal background, the traditional information retrieval system that searches laws and regulations based on keywords is not applicable because they do not have the ability to extract professional legal vocabulary from complex case processes. This paper proposes a law recommendation framework, called LawRec, based on Bidirectional Encoder Representation from Transformers (BERT) and Skip-Recurrent Neural Network (Skip-RNN) models. It intends to integrate the knowledge of legal provisions with the case description and uses the BERT model to learn the case description text and legal knowledge, respectively. At last, laws and regulations for cases can be recommended. Experiment results show that the proposed LawRec can achieve better performance than state-of-the-art methods.
Analysis of Clinical Characteristics and Influencing Factors for H-Type Hypertension Complicated with Other Chronic Diseases in a Community in Beijing
Authors: Li Tianlong , Wang Chen , Ma Li
Published: September 2022

Objective. The aim of the study is to analyze the clinical characteristics of patients with H-type hypertension complicated with other chronic diseases in a community in Beijing and to explore the influencing factors related to the occurrence of the disease by means of a case-control study. Methods. A questionnaire was designed. 362 residents with H-type hypertension in a community in Beijing were randomly enrolled from January 2020 to December 2021. The general data and clinical indexes of the patients were collected and their clinical characteristics were analyzed. According to the complications of other chronic diseases, they were divided into the simple hypertension group (n = 65) and the other chronic disease group (n = 297). Univariate and multivariate analyses were used to analyze the influencing factors for H-type hypertension patients with other chronic diseases. Results. Among the 362 H-type hypertension patients, 21 cases were aged 35–45 years, 35 cases were aged 45–55 years, and 127 cases were aged 55–65 years. The number of patients aged ≥65 years was 179, and the number of patients aged ≥55 years accounted for the highest proportion with a constituent ratio of 85.00%. Only 65 patients were patients with simple hypertension. The remaining 297 patients were complicated with different kinds of chronic diseases. The types of chronic diseases include malignant tumors, diabetes, rheumatoid arthritis, coronary heart disease, asthma, chronic obstructive pulmonary disease, systemic lupus erythematosus, and stroke. The proportion of H-type hypertension complicated with coronary heart disease, diabetes, and stroke is higher. Among the 297 patients, most of them were local, resident, and nonagricultural patients with a constituent ratio of 89.90%, 95.96%, and 98.98%, respectively. The prevalence rate of the male was 59.60% higher than that of the female at 40.40%. The blood types B and AB were more common. 90.57% of patients were married and the proportion of body mass index (BMI) was 45.79%. 60.61% of patients had a history of smoking, 55.56% had a history of drinking, 35.02% had a regular physical examination, 14.81% had regular exercise, and 37.71% had a light diet. There were significant differences in marital status, smoking, alcohol consumption, regular exercise, and light diet between the simple hypertension group and the chronic disease group (

P
<
0.05

). The results of the logistic regression analysis showed that smoking, drinking, little exercise, and not eating lightly were the independent risk factors for other chronic diseases (

P
<
0.05

). Conclusion. The incidence of H-type hypertension is higher in people ≥55 years old. Most of them are accompanied by three other chronic diseases: smoking, drinking, little exercise, and no light diet are also risk factors for chronic diseases.
Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics
Authors: Wei Jing , Lyu Jiaqi , Xiang Jie , Niu Yan , Yang Lan , Fan Chanjuan , Li Dandan , Yang Yanli
Published: September 2022

Parkinson’s disease (PD) is a common neurodegenerative disorder. Rapid eye movement sleep behavior disorder (RBD) is one of the prodromal symptoms of PD. Studies have shown that brain information transmission is affected in PD patients. Consequently, we hypothesized that brain information transmission is impaired in RBD and PD. To prove our hypothesis, we performed functional connectivity (FC) and functional dynamics analysis of three aspects—based on the whole brain, within the resting-state network (RSN), and the interaction between RSNs—using normal control (NC) (n = 21), RBD (n = 24), and PD (n = 45) resting-state functional magnetic resonance imaging (rs-fMRI) data sets. Furthermore, we tested the explanatory power of FC and functional dynamics for the clinical features. Our results found that the global functional dynamics and FC of RBD and PD were impaired. Within RSN, the impairment concentrated in the visual network (VIS) and sensorimotor network (SMN), and the impaired degree of SMN in RBD was higher than that in PD. On the interaction between RSNs, RBD showed a widespread decrease, and PD showed a focal decrease which concentrated in SMN and VIS. Finally, we proved FC and functional dynamics were related to clinical features. These differences confirmed that brain information transmission efficiency and flexibility are impaired in RBD and PD, and these impairments are associated with the clinical features of patients.
Risk Assessment of Green Intelligent Building Based on Artificial Intelligence
Authors: Xu Binjie
Published: September 2022

Green smart building is the development direction of future architecture. It is of great significance to carry out risk assessment. Fire risk is the key content of building risk, so this paper takes fire risk as the research object, with the help of artificial intelligence technology, to carry out the risk assessment research of green smart buildings. With the rapid development of the economy, urban fire risk factors are increasing, and the fire situation is becoming more and more serious. Building fire risk assessment is an important measure to effectively prevent and control urban building fires. This paper uses Internet of Things data to carry out fire risk assessment and realize Internet of Things data mining. Collect a large number of expert samples to build training samples, train the green intelligent building monomer fire risk assessment and prediction model based on deep neural network, constantly adjust the model parameters to optimize the model, and finally verify and modify the model.
APOE Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China
Authors: Rao Hui , Wu Heming , Yu Zhikang , Huang Qingyan
Published: September 2022

Objective. One of the causes of hypertension is a genetic factor. The purpose of this study was to look at the relationship between apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms and essential hypertension in the Hakka population. Methods. The study included 2,850 patients with hypertension and 2,034 controls. APOE rs429358, rs7412, and MTHFR rs1801133 were genotyped by polymerase chain reaction (PCR)-microarray. The differences in these polymorphisms between the two groups were analyzed. Results. The genotype and allele frequency of APOE and MTHFR polymorphisms did not differ significantly between hypertensive patients and controls. Patients with hypertension who were APOE rs429358C/C homozygous had higher TG, TC, LDL-C, and Apo-B levels, whereas patients with the T/T genotype had higher HDL-C levels. Patients with hypertension who were APOE rs7412T/T homozygous had higher TG and TC levels and lower LDL-C and Apo-B levels. Homocysteine (Hcy) levels in patients with MTHFR CC, CT, and TT genotypes were increased, while patients with the TT genotype and T allele had higher Hcy levels than those of patients with other genotypes and the C allele. The APOE rs7412T/T genotype in the co-dominant model (APOE rs7412T/T vs. C/C) (gender-, age-, smoking-, and drinking-adjusted OR 2.682, 95% CI, 1.072–6.710,P=0.035) was a significant risk factor for hypertension. The APOE rs429358 and MTHFR rs1801133 genotypes in co-dominant, dominant, and recessive models were not significant risk factors for hypertension. Conclusions. It supports that APOE polymorphisms are related to hypertension in the Hakka population. Specifically, the APOE rs7412T/T genotype may be a risk factor for hypertension.
A Comparative Optimization Model of Japanese Literature Characteristics for Cognitive Retrieval of Cross-Language Information
Authors: Feng Tao
Published: September 2022

Cross-language information cognitive retrieval has grown in importance as a study area due to the multilingual character of Internet resources and the diversifying languages spoken by users. This paper analyses and illustrates the key characteristics of Japanese literature from three aspects: ideological structure, structural form, and emotional expression, and makes a straightforward comparison with Chinese literature using a number of well-known Japanese literary masterpieces as examples. An important aspect of this literature is that it is full of lingering feelings, leaving room for the readers to imagine. The lingering charm is endless, obscure, and meaningful, which is the traditional style of Japanese literature. It also focuses on the depoliticization of Japanese literature, that is, the relative separation between literature and politics. The subjectivity of Japanese writing, which goes beyond just conveying feelings but involves less objective description, is related to this. The process of cross-language information retrieval in foreign nations is primarily separated into three stages, according to the changes in research objects. Currently, adding a language conversion mechanism to a monolingual information retrieval system serves as the primary language information retrieval solution. Currently, nearly 40% of the global popularity of literature comes from Japan. In this article, the background and concept of cross-language information retrieval are introduced, and its types, system models, and several key cross-language information retrieval methods are explained, and some solutions to the factors influencing the cross-language information retrieval effect are suggested.
High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein
Authors: Zhang Xin , Chen Hui , Lin Hui , Wen Ronglan , Yang Fan
Published: September 2022

Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome maintenance family that is necessary for the initiation of eukaryotic DNA replication. Overexpression of the MCM7 protein is linked to cellular proliferation and is accountable for critical malignancy in many cancers. Mechanistically, the suppression of MCM7 greatly lowers the cellular proliferation associated with cancer. Advances in immunotherapy have revolutionized treatments for many types of cancer. To date, no effective small molecular candidate has been found that can stop the advancement of cancer produced by the MCM7 protein. Here, we present the findings of methods that used a combination of structure-assisted drug design, high-throughput virtual screening, and simulations studies to swiftly generate lead compounds against MCM7 protein. In the current study, we designed efficient compounds that may combat all emerging cancer targeting the common MCM7 protein. For this objective, a molecular docking and molecular dynamics (MD) simulation-based virtual screening of 29,000 NPASS library was carried out. As a consequence of using specific pharmacological, physiological, and ADMET criteria, four new prevailing compounds, NPA000018, NPA000111, NPA00305, and NPA014826, were successfully selected. The MD simulations were also used for a time period of 50 ns to evaluate for stability and dynamics behavior of the compounds. Eventually, compounds NPA000111 and NPA014826 were found to be highly potent against MCM7 protein. According to our results, the selected compounds may be effective in treating certain cancer subtypes, for which additional follow-up experimental validation is recommended.
Prevalence of Reduced Vision among UK Elderly Drivers: The Bridlington Eye Assessment Project (BEAP)—A Cross-Sectional Study
Authors: Wilde Craig , Poostchi Ali , Panos Georgios D. , Hillman Jonathan G. , MacNab Hamish K. , Dua Harminder , Amoaku Winfried M. , Vernon Stephen A.
Published: September 2022

Self-assessment of driving fitness is mandatory in the United Kingdom. A paucity of data on visual function among drivers exists. We report prevalence of elderly drivers below legal visual acuity (VA) standard from a population study (The Bridlington Eye Assessment Project (BEAP)) conducted from 2002 to 2006. All residents aged ≥65 years were invited, 3459 undergoing structured interviews/ophthalmic examinations. Driving status was recorded, VA measured, and visual field (VF) testing performed. Outcomes were prevalence and characteristics of drivers below VA legal standard and prevalence of bilateral VF defects. Conditions causing reduced VA were explored and those with treatable conditions allowing visual improvement identified. Duration since last optometry review was recorded. Associations were explored using unpaired t-tests for continuous and chi-squared for discrete variables. Logistic regression was used for multivariate analysis and to determine odd ratios in the final adjusted model. Statistical analysis was performed using Stata 14.0 (Stata Corp, Tx). Within this sample, 7.1% (95% CI 6.0–8.3) of drivers fell below the VA legal driving standard (6/12) in their better eye, with 20% not having seen an optometrist for 2 years, including 8.2% who had not attended for over 5 years. The percentage of drivers falling below the VA minimum increases with age reaching 22.8% (95% CI 13.7–35.3) among those aged 85–89 years. 7.2% (95% CI 6.2–8.6) of drivers had bilateral visual field defects. 93% of drivers with reduced VA below legal standard had a cataract, refractive error or both in at least one eye. Significant numbers of elderly drive with VA below legal standard, most having easily correctable causes. Poor attendance with optometrists appears commonplace. Public education raised awareness of legal driving standards and encouraged compliance are required. Regular eye tests, appropriate refractive correction, and cataract surgery when needed should be encouraged.
Application of BP Neural Network in Teaching Quality Evaluation of Higher Vocational Education
Authors: Ai Leimei , Feng Tao
Published: September 2022

Higher vocational education has developed rapidly and attracted wide attention. Teaching quality evaluation is an important part of teaching management in classroom teaching and is an important part of teaching management. Based on the theory of teaching quality, 16 evaluation indicators are identified from the four aspects of teaching attitude, teaching content, teaching process, and teaching results and an HVE quality evaluation index system is constructed. The evaluation model is established by BP neural network algorithm. Finally, five higher vocational colleges in Henan Province are selected for empirical research. The results show that the evaluation model constructed in this paper has certain applicability and can provide a reference for HVE quality evaluation and improvement. Although the evaluation models herein have certain applicable values, further improvements are still needed in terms of indicator identification and correction.
Arbutin Inhibited Heat Stress-Induced Apoptosis and Promoted Proliferation and Migration of Heat-Injured Dermal Fibroblasts and Keratinocytes by Activating PI3K/AKT Signaling Pathway
Authors: Zhu Shugang , Yang Zhen , Kong Lili , Kong Lijun , Zhang Yuezhi
Published: September 2022

Objective. Studies have shown that arbutin has antioxidant and anti-inflammatory activities, which makes it suitable for treating skin wounds. We designed this study to investigate the effect of arbutin on heat-induced apoptosis, proliferation, and migration of dermal fibroblasts and keratinocytes and to explore the molecular mechanism. Methods. In vitro, HaCAT and dermal fibroblast (DFL) cells were cultured and used to establish a heat stress-injured skin cell model. We investigated the effects of arbutin on apoptosis, proliferation, and migration of HaCAT and DFL cells after heat stress injury. We then used immunoblotting to detect the expression of p-PI3K, PI3K, p-AKT, and AKT proteins for studying the underlying mechanisms and used a PI3K/AKT inhibitor (LY294002) to verify the efficacy of arbutin in HaCAT and DFL cells with heat stress injury. Results. Arbutin strongly inhibited heat stress-induced apoptosis, proliferation inhibition, and migration inhibition of HaCAT and DFL cells in vitro. Our results also showed that arbutin strongly decreased the ratio of Bax/Bcl2 protein expression and PCNA protein expression in HaCAT and DFL cells after treatment with heat stress. Furthermore, we also found that arbutin significantly increased the ratio of p-PI3K/PI3K and p-AKT/AKT protein expression, and LY294002 markedly reversed the effect of arbutin on heat stress-induced apoptosis, proliferation inhibition, and migration inhibition of HaCAT and DFL cells. Conclusion. Our finding indicated that arbutin inhibited heat stress-induced apoptosis and promoted proliferation and migration of heat-injured dermal fibroblasts and epidermal cells by activating the PI3K/AKT signaling pathway, suggesting that arbutin may provide an alternative therapeutic approach for the treatment of skin injury.
Correlation Analysis of Serum Pepsinogen, Interleukin, and TNF-α with Hp Infection in Patients with Gastric Cancer: A Randomized Parallel Controlled Clinical Study
Authors: Hao Shunxin , Shou Minyue , Ma Jing , Shu Yongqian , Yu Yuanyuan
Published: September 2022

Background. Gastric cancer pathological biopsy and visual examination have been the gold standard for gastric cancer diagnosis, but their operation is costly, demanding, and risky, so it is especially important to find an effective examination method in clinical practice. Aims. To investigate the correlation between serum pepsinogen I (PGI), pepsinogen II (PGII), pepsinogen I and II ratio (PGR), IL-6, and TNF-α and Helicobacter pylori (Hp) infection in patients with gastric cancer. Materials and Methods. Fifty patients with Hp-infected gastric cancer admitted to the Department of Gastroenterology of our hospital from January 2019 to December 2021 were selected for the study as the observation group, and another 50 patients without Hp-infected gastric cancer were selected as the comparison group to compare the correlation analysis of PGI, PGII, PGR, IL-6, and TNF-α with Hp infection between the two groups after admission and treatment. Results. After measurement, PGI and PGII in the observation group were significantly lower than those in the comparison group, and TNF-α, IL-18, and IL-6 in the observation group were significantly higher than those in the comparison group, and the comparative differences were all statistically significant (

P
<
0.05

). The results of multivariate logistic regression model analysis of independent risk factors for gastric cancer showed that IL-18, hs-CRP, and tumor necrosis factor- (TNF-) α were risk factors for Hp infection in gastric cancer. Conclusion. The expression of IL-18, hs-CRP, and TNF-α factors in Hp-infected gastric cancer patients is correlated. IL-6, IL-18, and TNF-α are involved in the entire process from the onset to the development of Hp-positive gastric mucosal inflammation in patients, which is of great value in the diagnosis of gastric cancer and helps to assess the degree of progression and prognosis of gastric cancer.
A Comparative Study of Four Nonlinear Dynamic Characteristics in Feature Extraction of Bearing Fault Diagnosis
Authors: Li Yuxing , Zhang Shuai , Liang Lili
Published: September 2022

To effectively extract the fault features of bearing signals in complex environments, four common nonlinear dynamic characteristics are used to analyze and compare the simulated signals and measured bearing fault signals in this paper, including Lempel-Ziv complexity (LZC), dispersion entropy (DE), Lyapunov exponent (LE), and fractal dimension (FD). Three groups of simulation experiments were carried out, and the simulation results show that all nonlinear dynamic characteristics can reflect the complexity change trend of MIX signal; compared with LZC and LE, DE and FD can better reflect the frequency change of amplitude modulated trend of chirped signal; only DE can reflect the amplitude change trend of amplitude modulated chirped signal. The experiments of feature extraction and classification are carried out for bearing fault signals. It concluded that compared with LZC, LE, and DE, FD has better stability and classification performance with the minimum standard deviation and the highest recognition rate.
Feasibility of a Novel Academic BCMA-CART (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis
Authors: Kfir-Erenfeld Shlomit , Asherie Nathalie , Grisariu Sigal , Avni Batia , Zimran Eran , Assayag Miri , Sharon Tatyana Dubnikov , Pick Marjorie , Lebel Eyal , Shaulov Adir , Cohen Yael C. , Avivi Irit , Cohen Cyrille J. , Stepensky Polina , Gatt Moshe E.
Published: September 2022

Purpose:

AL amyloidosis (AL) treatments are generally based on those employed for multiple myeloma. Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor T (CART)-cell therapy, already approved for multiple myeloma, might be too toxic for patients with AL.

Experimental Design:

Here we describe the ex vivo applicability of a novel in-house, academic anti-BCMA CAR construct on AL primary cells, as well as the safety and efficacy in 4 patients with relapsed/refractory (RR) primary AL, treated in a phase I clinical trial (NCT04720313).

Results:

Three had MAYO stage IIIa cardiac involvement at enrollment. The treatment proved relatively safe, with a short and manageable grade 3 cytokine release syndrome evident in 2 patients and no neurotoxicity in any. Cardiac decompensations, observed in 2 patients, were also short and manageable. The overall hematologic response and complete response rates were observed in all patients with an organ response evident in all four. Within a median follow-up period of 5.2 (2.5–9.5) months, all 4 patients maintained their responses.

Conclusions:

BCMA-CART cells provide a first proof-of-concept that this therapy is safe enough and highly efficacious for the treatment of patients with advanced, RR AL.
Abstract IA020: Reprogramming of myogenic transcription factors in rhabdomyosarcoma
Authors: Ford Heide L. , Hsu Jessica Y. , Danis Etienne P. , Nance Stephanie , O’Brien Jenean H. , Gustafson Annika L. , Wessells Veronica M. , Goodspeed Andrew E. , Talbot Jared C. , Amacher Sharon L. , Jedlicka Paul , Black Joshua C. , Costello James C. , Durbin Adam D. , Artinger Kristin B.
Published: September 2022

Rhabdomyosarcoma, a pediatric malignancy with partial resemblance to undifferentiated skeletal muscle, is characterized by high expression of myogenic-lineage transcription factors such as MYOD1 and MYOG. Despite high expression of these transcription factors, which in normal muscle result in differentiation, RMS cells fail to differentiate, suggesting the presence of factors that inhibit their normal differentiation-promoting functions. In this talk, I will present data that the key muscle transcriptional regulator, SIX1, which in development activates the myogenic regulatory factors (MRFs) and promotes muscle differentiation, in fact inhibits differentiation in fusion-negative (FN) RMS. SIX1 holds FN-RMS cells in a progenitor-like state by altering the chromatin landscape and causing MYOD1, a key MRF, to preferentially bind to regulatory regions of genes permissive to growth rather than differentiation. Loss of SIX1 results in re-localization of MYOD1 to promoters/enhancers of genes associated with differentiation, and further results in increased binding of MYOG at such loci. Altered binding of MYOD1 and MYOG in response to SIX1 loss results in marked inhibition of RMS growth in vivo, via induction of differentiation. These data suggest that SIX1 acts as a master regulatory factor controlling the fate of RMS cells. Data will be presented that suggest dynamic actions of SIX1 and its co-factors throughout normal muscle differentiation, whereby high levels of SIX1 expressed in early muscle differentiation may mimic a transcriptional state seen in RMS. We hypothesize that the specific levels of SIX1, combined with a unique combination of transcriptional co-factors, reprogram genome-wide binding of MRFs to different promoter/enhancer sites at specific developmental time points, and that RMS is trapped in an early developmental state where SIX1 represses differentiation via genome-wide alterations in MRF binding that favor growth. Understanding the co-factors that work with SIX1 to alter chromatin state and MRF binding may enable the discovery of novel targets whose inhibition could serve as a relatively non-toxic treatment to restore normal developmental processes and inhibit RMS progression.

Citation Format: Heide L. Ford, Jessica Y. Hsu, Etienne P. Danis, Stephanie Nance, Jenean H. O’Brien, Annika L. Gustafson, Veronica M. Wessells, Andrew E. Goodspeed, Jared C. Talbot, Sharon L. Amacher, Paul Jedlicka, Joshua C. Black, James C. Costello, Adam D. Durbin, Kristin B. Artinger. Reprogramming of myogenic transcription factors in rhabdomyosarcoma [abstract]. In: Proceedings of the AACR Special Conference: Sarcomas; 2022 May 9-12; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(18_Suppl):Abstract nr IA020.
Economic dispatch of an islanded microgrid
Authors: Satya Gowthami Thimmapathruni Venkata , Bhanu Chennapragada Venkata Krishna
Published: September 2022

Microgrids are increasingly becoming popular to improve energy access and increase the resiliency of weakly connected rural networks. The economic operation of these microgrids with renewable energy resources is key for maximizing the benefits. The objective of this paper is to implement the economic dispatch of a microgrid using quadratic programming, considering the active and reactive power capability of the renewable energy resources. The open distribution system simulator (OpenDSS) is used for obtaining the load flow of the distribution network, and the converged solution is given as input to MATLAB for optimization. The simulation is carried out for one day with a variation of hourly load, solar PV radiation, and wind in both grid-connected and islanded modes under six different cases. The methodology is implemented on a modified IEEE-13 node test feeder distribution system. The simulation result shows that the microgrid with distributed generation (DG) capable of supplying both active and reactive power under islanded conditions is economical when compared to the grid-connected mode. The novelty of the work is that it considers the capability of distributed generation to supply both active and reactive power. That can make it fully autonomous as it can meet the hourly load requirement of the network under islanding mode as per IEEE Standard 1547.4.
Large-scale wind power grid modelling and stability evaluation using stochastic approaches
Authors: Attachie Joseph C. , Amuzuvi Christian K. , Diamenu Godwin
Published: September 2022

With the global demand to increase the level of low-carbon renewable energy resources (RERs) for electric power generation, dwindling fossil fuel reserves, and concerns that fossil fuel emissions are leading to climate change with possibly disastrous consequences, research is underway to discover the probable large-scale usage of RERs that will not be integrated into an existing power grid. A large-scale RER power grid is anticipated to run independently and be stable and dependable, like a traditional system. Wind power generation is no longer negligible. Wind energy is one of the most established renewable power options for ensuring RE self-sufficiency, but it's also one of the ficklest (RERs). Wind power generation is predicted to rise quickly in the next years owing to interest in renewable energy to counteract global warming. National or regional RE power networks are the subjects of growing study. The issue is the grid's stability and dependability. Wind farms' production variability, intermittency, and load mismatch can damage grid voltage stability. In answer to this difficulty, a large-scale wind power system was modeled using a stochastic methodology, and the results were analyzed using the Lyapunov technique, matrix exponential, and Hurwitz criteria to determine the future stability of a 100% RE grid.
Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association
Authors: Levine Glenn N. , McEvoy John W. , Fang James C. , Ibeh Chinwe , McCarthy Cian P. , Misra Arunima , Shah Zubair I. , Shenoy Chetan , Spinler Sarah A. , Vallurupalli Srikanth , Lip Gregory Y.H. ,   on behalf of the American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Published: September 2022

Despite the many advances in cardiovascular medicine, decisions concerning the diagnosis, prevention, and treatment of left ventricular (LV) thrombus often remain challenging. There are only limited organizational guideline recommendations with regard to LV thrombus. Furthermore, management issues in current practice are increasingly complex, including concerns about adding oral anticoagulant therapy to dual antiplatelet therapy, the availability of direct oral anticoagulants as a potential alternative option to traditional vitamin K antagonists, and the use of diagnostic modalities such as cardiac magnetic resonance imaging, which has greater sensitivity for LV thrombus detection than echocardiography. Therefore, this American Heart Association scientific statement was commissioned with the goals of addressing 8 key clinical management questions related to LV thrombus, including the prevention and treatment after myocardial infarction, prevention and treatment in dilated cardiomyopathy, management of mural (laminated) thrombus, imaging of LV thrombus, direct oral anticoagulants as an alternative to warfarin, treatments other than oral anticoagulants for LV thrombus (eg, dual antiplatelet therapy, fibrinolysis, surgical excision), and the approach to persistent LV thrombus despite anticoagulation therapy. Practical management suggestions in the form of text, tables, and flow diagrams based on careful and critical review of actual study data as formulated by this multidisciplinary writing committee are given.
Taxonomic studies on Dasyproctus Lepeletier & Brullé (Hymenoptera: Crabronidae) from North Vietnam with description of two new species
Authors: PHAM PHONG HUY
Published: September 2022

Seven species of Dasyproctus Lepeletier & Brullé, 1835 (Hymenoptera: Crabronidae) are recorded from North Vietnam. Of these, D. vietnamensis and D. longi are new species, and D. idrieus (Cameron) and D. pentheri Leclercq are recorded for the first time from the country. Keys to both sexes of Dasyproctus from North Vietnam based on morphological characters are given, and new distributional records are also presented.
Does Democracy Matter for Public Health?
Authors: Lee Sanghoon
Published: September 2022

This study examines the effect of democracy on public health by using panel data of 188 countries over the period 1972–2019. We use various regression methods, such as pooled ordinary least squares, fixed effects, dynamic generalized method of moments (GMM), a split-sample method, and a quadratic model to address econometric issues. The pooled regression supports the positive effect on health, but it does not exist in low-income countries, which can be explained by the threshold effect. The fixed effects regression confirms the positive impact on infant mortality but not on life expectancy, which illustrates the historical and cumulative effect of democracy on life expectancy. The non-linear regression finds a U-shaped relationship between democracy and infant mortality, which is consistent with the fixed effects regression result of the positive effect on mortality in the low-income group. The dynamic GMM regression shows the expected strong relationship between previous health and current health status. Overall, the regression analysis supports the positive effect of democracy on public health.
Andy Van de Ven’s Wonderfully Full Life
Authors: Bartunek Jean M. , Garud Raghu B. , Meyer Alan D.
Published: September 2022

In this short paper we recognize and celebrate the life and contributions of Andy Van de Ven, a renowned professor at the University of Minnesota and a former president of the Academy of Management. Andy published in JABS multiple times over his career and was a longtime member of its editorial board. His work was exemplary for many things, including his formulation of engaged scholarship, his creativity, his multiple innovations in theory and practice, and the ways he inspired so many others. Without him the Academy, writ large, would have been much poorer.
Identifying Digital Rhetoric in the Telemedicine User Interface
Authors: Campbell Jessica Lynn
Published: September 2022

Telemedicine is an alternative healthcare delivery system whereby patients access digital technology to consult with a physician virtually. Patients first interact with telemedicine via a consumer-facing website. Telemedicine promises numerous benefits to patients, such as increased access to healthcare, yet poor usability of the telemedicine user interface (UI) may hinder patient acceptance and adoption of the service. The telemedicine UI moderates patients’ ability to utilize telemedicine, and therefore it must be usable, but it must also be rhetorical to motivate patients to perform certain actions. Digital rhetoric refers to UI elements that influence user actions and knowledge and is tied to usability because of these same human–computer interaction (HCI) factors. This study examined the usability of three telemedicine provider UIs and by identifying usability problems, reveals digital rhetoric that is significant to telemedicine UIs. The article concludes by offering heuristics of digital rhetoric that lead to optimal usability.
The Relationship between God Attachment, Transdiagnostic Processes, and Symptoms of Psychopathology among Christian Adults
Authors: Knabb Joshua J. , Boyd Heather R. , Duvall Katie S. , Lowell Jessie R.
Published: September 2022

In this study, we drew from the psychology of religion and clinical literatures to investigate the relationship between insecure God attachment, key transdiagnostic processes, and symptoms of psychopathology. Specifically, with an archival sample of online Christian adults ( N = 437), we explored the potential mediating influence of three popular, well-researched constructs (i.e., experiential avoidance, intolerance of uncertainty, and repetitive negative thinking) in the transdiagnostic literature to explain the link between anxious and avoidant God attachment and common symptoms of psychopathology (i.e., depression, anxiety, and stress). Results revealed that all three transdiagnostic constructs mediated the association between anxious and avoidant God attachment and depression, anxiety, and stress. Clinical applications are briefly discussed for Christians struggling with unhelpful transdiagnostic processes, as are study limitations.
Non-steroidal anti-inflammatory drugs (NSAIDs) in cancer pain: A database analysis to determine recruitment feasibility for a clinical trial
Authors: Page Andrew J , Spencer Katie , Mulvey Matthew R , Laird Barry JA , Bennett Michael I
Published: September 2022

Background:

Insufficient evidence exists to support or refute use of NSAIDs for managing cancer pain. Palliative physicians support a placebo-controlled trial of NSAIDs as strong opioid adjuncts for cancer-induced bone pain as the most pragmatic design to benefit clinical practice.

Aim:

We aimed to determine patient numbers receiving palliative radiotherapy for cancer-induced bone pain, estimate the suitability of NSAID prescription and determine survival, guiding future trial feasibility.

Design:

A retrospective observational database analysis was undertaken using 5 years of routinely collected regional radiotherapy and healthcare data, filtered to achieve a cohort with cancer-induced bone pain. Demographics and survival were linked to available serology and co-morbidity data.

Setting/participants:

Data was sourced from the regional Leeds Cancer Centre, a tertiary care setting. Patients who underwent palliative single fraction 8 gray (Gy) radiotherapy treatment for cancer-induced bone pain were included, totalling 2411 over 5 years.

Results:

A mean of 478 patients received palliative radiotherapy for cancer-induced bone pain annually. Median age (IQR) was 70 (62–77); negatively skewed (−0.69). 65.3% died within 1 year of radiotherapy; 48.0% within 6 months. Age was not associated with survival on univariable analysis (HR 0.999 (95% CI 0.996–1.003)). Serology from 1063 patients (44.2%) were available; eGFR was ⩾60 mL/min/1.73 m2 in 83.0%. From available data (1352 pts; 51.6% of sample), 20.2% had a coded co-morbidity contra-indicating NSAIDs. Combining serology and co-morbidities, 68.5% could be considered for NSAID prescription.

Conclusions:

Patient numbers at a regional radiotherapy centre support the feasibility of trial recruitment. Available serology and co-morbidity data suggest two-thirds may be suitable for NSAID prescription.
Strategies for recruiting the dependent children of patients with a life-limiting illness as research participants
Authors: Marshall Steve , Stephenson Pam , Sheehan Denice
Published: September 2022

Background:

The voices of children and adolescents have historically been substituted by the perspective of adults. There is growing recognition that children (<18 years old) are able to participate in research and appreciate the opportunity to participate in studies.

Aim:

To share the strategies employed by two research teams from USA and UK, who have successfully recruited children living with parental life-limiting illness as research participants.

Findings:

The researchers overcame common challenges when negotiating ethics committees by anticipating the IRB/REC concerns, providing the committees with detailed applications including distress protocols, and offering resources to their ethics committee to learn about conducting research with this population. The researchers navigated recruitment and gatekeeping by clinicians and parents by partnering with clinical agencies and nurturing relationships with practitioners who are supportive of the research, offering to present the findings of the study with continuing education credits, and developing children’s, adolescents’ and parents’ project advisory groups to support recruitment, data collection and analysis.

Conclusions:

Simple strategies can be used to overcome barriers to recruitment, providing opportunities for children to be research participants and for their unique perspectives to be heard in palliative care research.