bluuebunny/crossref_metadata_2025 huggingface dataset:
Second-line Treatment of Advanced Non-small Cell Lung Cancer Non-oncogene Addicted: New Treatment Algorithm in the Era of Novel Immunotherapy
Authors: Gridelli Cesare , Ascierto Paolo Antonio , Grossi Francesco , Baldini Editta , Favaretto Adolfo , Garassino Maria Chiara , Morabito Alessandro , Migliorino Maria Rita , Rossi Antonio , de Marinis Filippo
Published: July 2018

Background:

Most patients with advanced non-small cell lung cancer (NSCLC) have a
poor prognosis and receive limited benefit from conventional treatments, especially in later lines of
therapy. In recent years, several novel therapies have been approved for second- and third-line
treatment of advanced NSCLC beyond old chemotherapy agents (docetaxel and pemetrexed) and
the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI, erlotinib). In particular,
the new antiangiogenetics (nindetanib and ramucirumab) in combination with docetaxel and
immunotherapy (nivolumab, pembrolizumab and atezolizumab) have been recently approved and
represent new treatment options.

Methods:

The Italian Association of Thoracic Oncology (AIOT) organized five meetings in different
Italian regions representing North, Middle and South of the country in order to discuss the issue.

Results:

In light of these new approvals, it is valuable to understand the uptake of these new therapies
in routine clinical practice and their impact on patient care. With these treatment options to
define an appropriate algorythm is object of debate.

Conclusion:

The present paper discusses the old and new treatment opportunities, proposing a
shared algorithm for second-line setting in advanced NSCLC.
Diabetes, Care Homes, and the Influence of Technology on Practice and Care Delivery in Care Homes: Systematic Review and Qualitative Synthesis (Preprint)
Authors: Mathews Rebecca , O'Malley Chris , Hall Jenny M , Macaden Leah , MacRury Sandra
Published: July 2018

BACKGROUND

Diabetes is increasing in prevalence and complexity in the care home setting, affecting up to a quarter of care home residents. Health outcomes for these residents are impacted by management of the disease, health care professionals (HCPs)’ decision-making skills within the care home setting, and access to specialist services. The use of technology has the potential to recognize opportunities for early intervention that enables efficient responsive care, taking a fundamental role in linking the care home community to wider multidisciplinary teams for support.

OBJECTIVE

The aim of this paper was to identify evidence that explores factors relevant to the use of technology in and around the care home setting to aid in the management of diabetes.

METHODS

Databases searched using a structured prespecified approach included: PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), OVID Nursing database, Scopus, MEDLINE, the Cochrane Library, and the King’s Fund from 2012 to 2017: handsearching was undertaken additionally for any gray literature. Preferred Reporting Items for Systematic review and Meta-Analysis Protocol was used as protocol with Risk of Bias in Systematic reviews a tool to assess the risk of bias across studies. Studies had to include interventions that combined technology to or from the care home setting to support residents living with diabetes.

RESULTS

The combined search strategy identified a total of 493 electronic records. Of these, 171 papers were screened for eligibility, 66 full papers were accessed, and 13 have been included in this study. Qualitative synthesis has identified different strands of research evidence in what and how technology is currently being used in and around care homes to enhance diabetes management. New initiatives and implementations of technology and emerging models of care that included the use of technology have also been included.

CONCLUSIONS

By triangulating the perspectives of HCPs, practitioners, specialists, and members of the care home community, the authors anticipate that this review will represent an up-to-date, evidence-based overview of the potential for using technology within the care home setting for diabetes management as well as stimulate research in this area.
Tomographically reconstructed master equations for any open quantum dynamics
Authors: Pollock Felix A. , Modi Kavan
Published: July 2018

Memory effects in open quantum dynamics are often incorporated in the equation of motion through a superoperator known as the memory kernel, which encodes how past states affect future dynamics. However, the usual prescription for determining the memory kernel requires information about the underlying system-environment dynamics. Here, by deriving the transfer tensor method from first principles, we show how a memory kernel master equation, for any quantum process, can be entirely expressed in terms of a family of completely positive dynamical maps. These can be reconstructed through quantum process tomography on the system alone, either experimentally or numerically, and the resulting equation of motion is equivalent to a generalised Nakajima-Zwanzig equation. For experimental settings, we give a full prescription for the reconstruction procedure, rendering the memory kernel operational. When simulation of an open system is the goal, we show how our procedure yields a considerable advantage for numerically calculating dynamics, even when the system is arbitrarily periodically (or transiently) driven or initially correlated with its environment. Namely, we show that the long time dynamics can be efficiently obtained from a set of reconstructed maps over a much shorter time.
“It’s lobbying, stupid!”: Como grupos de interesse estrangeiros afetam as negociações comerciais brasileiras
Authors: Netto Pedro Henrique de Souza
Published: July 2018

Nos últimos anos, o Brasil modificou sua política comercial e passou a buscar novos acordos comerciais. Apesar disso, há sérias dificuldades nas negociações de produtos agropecuários. Grupos de interesse estrangeiros têm papel relevante nesses empecilhos, e devem ser lembrados nas ações dos setores público e privado brasileiro.
A descentralização no discurso de bancos multilaterais de desenvolvimento
Authors: Makino Rogerio
Published: July 2018

Esse texto discute a descentralização como uma questão que perpassa transversalmente a ideia da consolidação do federalismo de fato. Defende-se que a apologia por parte de alguns bancos multilaterais de desenvolvimento a um modelo específico de federalismo com um número muito grande de prerrogativas descentralizadas tem a ver com a lógica da monocultura institucional, ou seja, a ideia de que existem arranjos institucionais que são aprioristicamente superiores e que podem e devem ser adotados em todos os lugares independentemente de suas idiossincrasias.
Childhood Tuberculosis and its Relation with Nutrition
Authors: Chhetri Uma , Mishra Aparna , Jain Kastur Chand , Bhandari Keshav Raj
Published: July 2018

Introduction: Tuberculosis is the sixth leading cause of mortality in Nepal. Childhood tuberculosis consisted 5.54% of newly registered 32,056 cases in 2016-17. Malnutrition is a predictor of tuberculosis and is associated with poorer outcomes. This study evaluates the clinico-epidemiologic profile of childhood tuberculosis and its relation to nutritional status.

Methods: This was a retrospective review of 60 cases of tuberculosis admitted over a period of five years. Details regarding demographics, anthropometry, symptomatology and examination findings were retrieved. Diagnosis was categorized as pulmonary, extra-pulmonary and disseminated tuberculosis. Findings of various investigations were noted. Nutritional status of the patients was assessed using the WHO standard charts. Association of malnutrition and anemia with types and severity of tuberculosis was assessed.

Results: A total of 60 patients were included in the study. Mean age was 7.9 years (SD = 4.6). The commonest presenting symptom was fever (83.3%) followed by decreased appetite (33.3%) and weight loss (26.7%). Cough was the predominant symptom in pulmonary tuberculosis (45%). Only eight cases were bacteriologically confirmed. Underweight, wasting and stunting were observed in 68.4%, 63.3% and 53.3% of cases respectively. Wasting was significantly associated with severe forms of tuberculosis (p = 0.03). Anemia was present in 89.5% of under five children (p = 0.02).

Conclusion: Malnutrition often co-exists in a significant proportion of children with tuberculosis. Diagnosis in resource limited settings heavily relies on clinical suspicion and supporting investigations. Anemia is significantly associated with childhood TB, especially under five children.
New observations and transit solutions of the exoplanets HAT-P-53b and XO-5b
Authors: Kjurkchieva Diana , Petrov Nikola , Ibryamov Sunay , Nikolov Grigor , Popov Velimir
Published: July 2018

We present photometric observations of transiting exoplanets HATP-53b and
XO-5b by the Rozhen 2 m telescope. The modeling of the HAT-P-53b transit
required bigger planet radius than the previously published value due to the
bigger depth of the newly-observed transit. The transit solution of XO-5b
led to values of fitted parameters within errors of the previously published
results. Based on a time span of around 9 years we improved the orbital
period of XO-5b to the value of 4.187751515 d. The quality of our data does
not allow determination of planet temperatures by the transit solutions. Our
results confirmed the Jupiter type of the two targets. The more bloated
nature of HAT-P-53b is a result of its considerable closer orbit and higher
temperature of the host star. The best fits of the newly-observed transits
of HAT-P-53b and XO-5b correspond to the quadratic limb-darkening law of
their host stars whose coefficients were determined. The high sensitivity of
the transit solutions to the stellar limb-darkening law and its coefficient(
s) is proposed as a tool for precise empirical investigation of the
limb-darkening effect of host stars and its interpretation.
The relation between management fees and the mutual funds` performance in Poland in 2015
Authors: Fraś Alicja
Published: July 2018

Research background: The investor`s expectation of better performance in the case of more expensive mutual funds seems natural and fully justified. However, the rise of passive funds and their surprisingly good results, especially when taking into account their low fees, triggered the discussion. Recent years have brought more and more studies, conducted mostly for the American market, discrediting high-charging, aggressive funds. First analyses in Poland also indicate that the level of fees is not always linked with the fund?s performance.

Purpose of the article: The purpose of the study is to investigate the relation be-tween the fees imposed by the mutual funds and the funds` performance. The idea is to verify, whether higher management fees are associated with top performance and whether it is rational to pay more for capital management.

Methods: In the first step of the study, linearity and direction of the dependency was explored, using scatterplots and correlation analysis. In the second part, the linear regression was created to verify the strength of the relation. One-factor models have been built with the rate of return and standard deviation as independent variables for 1-, 3- and 5-year time horizons. Moreover, two-factor models, including both rate of return and risk has been created, to compare the significance of return and risk factor.

Findings & Value added: The results indicated that more expensive Polish mutual funds in 2015 tended to perform worse in all tested time horizons ? both in terms of lower rates of return and higher risk. Especially unexpected are the results of rates of return regression analysis ? it turns out that within a sample 1% higher fee implied over 0.6% lower rate of return before fees (in yearly period). Nonetheless, the risk turned out to be more important, explaining the charges variability much better than the rate of return. Another interesting finding of the study is that merely two simple factors (return and risk) explain even as much as 60% of the management fee variability.
SMEs innovativeness and institutional support system: the local experiences in qualitative perspective. Polish case study
Authors: Lewandowska Anna , Stopa Mateusz
Published: July 2018

Research background: Many contemporary empirical studies and most economic growth theories recognize the importance of innovation as one of the most progressive determinants of socio-economic growth, both in the regional and local perspective. However, much of the empirical literature has discussed the issue of innovativeness and institutional environment without the significant results for small enterprises, especially in peripheral regions.

Purpose of the article: The aim of this paper is to evaluate the institutional support system and its impact on SME innovativeness in Podkarpackie region. In analyzing this case, we raise the following two questions: (1) what are the types of innovation strategies of SMEs in Podkarpackie? (2) what are the factors affecting innovation and potential barriers to further use of institutional support systems aimed at the implementation of innovation in enterprises?

Methods: Based on the empirical research, we have analyzed the data (individual in-depth interviews) and found out how the entrepreneurs, R&D, business environment institutions, regional and local authorities assess the use of programs and projects dedicated to innovation in the scope of the institutional support system and what are the barriers encountered by entrepreneurs that limit the implementation of innovation.

Findings & Value added: The results of our research show that institutional sup-port systems mitigate negative consequences of peripheral localization of the enterprises, where specific innovation strategy has no influence on SME assessment of innovation effectiveness. Innovation is too costly, and SMEs are too weak in peripheral regions, therefore there is great need for reasonable and flexible institutional support systems. However, the peripheral situation influences this institutional system itself, strengthening the mechanisms of self-censorship.
Catalytic conversion of ethanol into alkenes and acetaldehyde
Authors: Godová Nikoletta , Horváth Blažej
Published: July 2018

Bioethanol is an example of a renewable energy source which can be produced not only by fermentation of simple sugars but also by depolymerisation of cellulose, as the second-generation feedstock, in the first step. This will help to further develop the bioethanol economy. Ethanol can be used as a promising platform molecule for the production of a variety of industrially important chemicals such as alkenes or oxygenates. Alkenes are produced industrially by petrochemical way mainly from crude oil, a non-renewable energy source. Conversion of ethanol to light olefins using an appropriate catalyst could replace the production of these key building blocks for the chemical industry. In this work, the focus is on the preparation and testing of heterogeneous catalysts in the transformation of ethanol to alkenes and acetaldehyde. In most cases, magnesia-based catalysts were used on a silica support during the experiment. Individual types of catalysts were compared in terms of yields of particular products, the effect of the feedstock load and that of calcination temperature of the catalyst on the catalytic activity are discussed. The highest ethylene yields (95 %) were achieved over an Mg-β-zeolite catalyst; the highest yield of 1,3-butadiene (29.1 %) was achieved in case of an Na/alumina catalyst; and the highest acetaldehyde yield (22.3 %) was achieved using a K-doped MgO/SiO2 catalyst.
Influence of relevant parameters on the extraction efficiency and the stability of the microdrop in the single drop microextraction
Authors: Zichová Silvia , Brisudová Adriána , Hrouzková Svetlana
Published: July 2018

Single drop microextraction technique uses microamounts of organic solvents. Simplicity, low cost, low environmental impact, compatibility with chromatographic systems as well as its applicability to different matrices are main advantages of single drop microextraction. This technique has become frequently used for the extraction of a broad scope of compounds for numerous analytical applications. This review provides an overview of the existing single drop microextraction modes of realisation and the main scope is devoted to the optimization of parameters influencing the efficiency. The state of the art is discussed on the basis of examples selected from representative application areas. Extraction parameters for toxic organic compounds extraction and microdrop stability were evaluated.
Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids
Authors: Vučinić Slavica , Kilibarda Vesna , Đorđević Snežana , Đorđević Dragana , Perković-Vukčević Nataša , Vuković-Ercegović Gordana , Antonijević Biljana , Ćurčić Marijana , Antonijević Evica , Brajković Gordana
Published: July 2018

A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea, vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as “Biljni tamjan” (herbal incense), “Beli slez”, and “Rainbow Special” and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHMICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.
Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings
Authors: Semren Tanja Živković , Žunec Suzana , Pizent Alica
Published: July 2018

This review article provides a summary of the studies relying on oxidative stress biomarkers (lipid peroxidation and antioxidant enzymes in particular) to investigate the effects of atrazine and terbuthylazine exposure in experimental animals and humans published since 2010. In general, experimental animals showed that atrazine and terbuthylazine exposure mostly affected their antioxidant defences and, to a lesser extent, lipid peroxidation, but the effects varied by the species, sex, age, herbicide concentration, and duration of exposure. Most of the studies involved aquatic organisms as useful and sensitive bio-indicators of environmental pollution and important part of the food chain. In laboratory mice and rats changes in oxidative stress markers were visible only with exposure to high doses of atrazine. Recently, our group reported that low-dose terbuthylazine could also induce oxidative stress in Wistar rats. It is evident that any experimental assessment of pesticide toxic effects should take into account a combination of several oxidative stress and antioxidant defence biomarkers in various tissues and cell compartments. The identified effects in experimental models should then be complemented and validated by epidemiological studies. This is important if we wish to understand the impact of pesticides on human health and to establish safe limits.
Characterization of Inclusion Complexes between Miconazole and Different Cyclodextrin Derivatives
Authors: Kelemen Hajnal , Hancu Gabriel , Gâz-Florea Serban Andrei , Nemes-Nagy Eniko , Papp Lajos Attila , Mircia Eleonora
Published: July 2018

Objective: Miconazole, an imidazole antifungal derivative, is a very hydrophobic compound, a major drawback in obtaining topical pharmaceutical formulations with optimal bioavailability. Cyclodextrins (CDs) may increase local drug delivery by enhancing the drug release and/or permeation. The aim of the study is the characterization of inclusion complexes between miconazole and different CD derivatives.

Methods: Several CD derivatives were tested in the experiments. The binary systems between miconazole and different CDs were prepared in 1:1 molar ratios by physical-mixture and kneading methods. Differential scanning calorimetry (DSC) and Fourier transformed-infrared spectroscopy (FT-IR) methods were used to characterize solid state interactions between miconazole and CDs in their binary systems.

Results: The FT-IR analysis suggests the formation of a new solid phase, indicating a molecular interaction between the components. The DSC analysis sustains the hypothesis of formation of partial inclusion complexes between miconazole nitrate and CD.

Conclusion: The thermic behaviour of the complexes depends both on the preparation method and the composition of the products.
An overview of statistical methods to detect and understand genotype-by-environment interaction and QTL-by-environment interaction
Authors: Rodrigues Paulo C.
Published: July 2018

Genotype-by-environment interaction (GEI) is frequently encountered in multi-environment trials, and represents differential responses of genotypes across environments. With the development of molecular markers and mapping techniques, researchers can go one step further and analyse the whole genome to detect specific locations of genes which influence a quantitative trait such as yield. Such a location is called a quantitative trait locus (QTL), and when these QTLs have different expression across environments we talk about QTL-by-environment interaction (QEI), which is the basis of GEI. Good understanding of these interactions enables researchers to select better genotypes across different environmental conditions, and consequently to improve crops in developed and developing countries. In this paper we present an overview of statistical methods and models commonly used to detect and to understand GEI and QEI, ranging from the simple joint regression model to complex eco-physiological genotype-to-phenotype simulation models.
Shakedown Analysis of “Soil-Pile Foundation-Frame” System under Seismic Action
Authors: Alawdin Piotr , Bulanov George
Published: July 2018

In this article, the seismic shakedown FEM analysis of reinforced concrete and composite spatial frame structures on the deformable foundation, taking into account the elasticplastic and brittle behavior of structures elements, is presented. A foundation consists of group of the piles in the soil. The behavior of soil is described here using+ the elastic halfspace theory. The pile deformation model is assumed to be elastic-perfectly plastic, where the bearing capacity is determined by the results of testing the soils or the piles themselves. An example of seismic shakedown limit analysis is presented.
Information and communication technologies and teacher education in the new paradigms of higher education
Authors: Müller Mirella , Begović Ines , Baumgärtner Ralf
Published: July 2018

Media use in the teaching process occurs in several forms. Information and communication technologies can be used as work equipment and teaching aids, as well as tools or curriculum units, particularly in higher education. Technological changes and new information technologies, in addition to substantive knowledge of the material, require from teachers creativity, knowledge, and the skills of the didactic design of teaching using modern multimedia tools. In Croatia, there is a lack of research aimed at assessing the initial state of computer literacy within the higher education institutions. The aim of this study was to determine the level of knowledge and digital competence of (non) teachers of higher education institutions in the Republic of Croatia, to determine the frequency of application of modern technologies in teaching, and to explain the necessity of implementation of the programme Multimedia training and e-learning at teaching faculties, which leads to the application of new educational paradigms. The study was conducted on a representative sample (N=1800) of (non) teachers of higher education institutions in the Republic of Croatia among various faculties and departments in Osijek, Split and Zagreb. The results show that (non) teachers of higher education institutions of engineering and information sciences have the best digital competences, and apply modern technology in research and scientific work significantly more than (non) teachers of social sciences and humanities.
Purchasing power parity in ASEAN+3: an application of panel unit root tests
Authors: Boršič Darja , Bekő Jani
Published: July 2018

The paper assesses the existence of purchasing power parity (PPP) in ASEAN+3 economies taking into account EUR and USD as reference currencies. The research refers to the period from January 2000 to June 2017 and there are three points of view: we tested the period as a whole and then the pre-crisis period and the postcrisis period regarding the structural break due to the economic crisis. The evaluated economies include Brunei, Cambodia, China, Indonesia, Japan, Korea, Laos, Malaysia, Myanmar, the Philippines, Singapore, Thailand and Vietnam. A range of panel unit root tests are applied, covering the Levin, Lin and Chu test, the Breitung test, the Im, Pesaran and Shin test, the ADF-Fisher test and the PP-Fisher test. In cases where the unit root is rejected, the validity of PPP is confirmed. However, our results are ambiguous and depend on the selection of the base currency, the time period observed and on the choice of the methodology.
Influence of inosine pranobex on cell viability in normal fibroblasts and liver cancer cells
Authors: Tobólska Sylwia , Terpiłowska Sylwia , Jaroszewski Jerzy , Siwicki Andrzej Krzysztof
Published: July 2018

Introduction

Inosine pranobex (Isoprinosine) stimulates cell-mediated immune responses to viral infections in humans and might have also therapeutic use in animals. The aim of this study was to compare three in vitro cytotoxicity assays on mouse embryo fibroblasts and liver cancer cells and determine their ability to detect early cytotoxic effects for inosine pranobex.

Material and Methods

BALB/3T3 clone A31and HepG2 cells were incubated with inosine pranobex at concentrations from 0.1 to 1,000 μg/mL. Cell viability was determined with the MTT reduction, the LHD release, and the NRU tests.

Results

A decrease in the cell viability was observed after incubating the BALB/3T3 clone A31and HepG2 cells with inosine pranobex.

Conclusions

Based on the cytotoxicity endpoints measured in these investigations in BALB/3T3 clone A31cells, it can be concluded that the cell membrane may be the first part of the cell to be affected by inosine pranobex. The disintegration of lysosomes and mitochondria follows mitochondria damage. In HepG2 cells likewise, the cell membrane may be the first part of the cell to be affected by inosine pranobex. Also in liver cancer cells, the disintegration of mitochondria (assessed with the MTT reduction assay) and next of lysosomes (assessed with the NRU assay) follows mitochondria damage.
Analysis of the Breathing Air Production Process for Hyperbaric Purposes
Authors: Woźniak Arkadiusz
Published: July 2018

The quality of breathing air plays a key role in the safety of divers and hyperbaric facilities. Paradoxically, the change of regulations concerning quality requirements for breathing mixes has imposed the need for verification of the technical and laboratory bases used in their production and control. This article presents the results of research related to the rationalisation of the process of production and supply of breathing air for the purposes of hyperbaric oxygenation. The work was carried out using the SixSigma method.
The Knowledge of a Selected Group of Medical Students on Hyperbaric Oxygen Therapy
Authors: Henrykowska Gabriela , Buczyński Andrzej , Lewicka Małgorzata , Zawadzka Magdalena
Published: July 2018

During the last decades, there has been a rapid development in the research and use of hyperbaric oxygen therapy (HBO), and modern medicine is increasingly taking advantage of its beneficial effects. The aim of the study was to check the level of knowledge of future doctors (medical students) on hyperbaric oxygen therapy.

The survey was conducted among 240 students of the medical faculty (3rd and 5th year of study) of the Military and Medical Faculty of the Medical University of Lodz. The author’s questionnaire with forced-choice questions was used as research tool.

The students’ knowledge of hyperbaric oxygen therapy was varied and in some cases was not dependent on the year of study. It was observed that students’ knowledge of the subject matter depends on the number of teaching hours allocated to it.
A Model of OFDM based Maritime VHF Communication System for Data Exchange
Authors: Valčić Sanjin , Pogány Tibor , Mrak Zoran
Published: July 2018

In the maritime Very High Frequency (VHF) band, there are no systems for transmitting large amounts of data. Therefore, it is necessary to develop new systems that would modernize the Global Maritime Distress and Safety System (GMDSS), significantly relieve the Automatic Identification System’s (AIS) communication channels, and set guidelines for the development of communication infrastructure of the e-Navigation. In line with this, analytical and simulation models of the maritime VHF data transmission communication system using Orthogonal Frequency Division Multiplexing (OFDM) modulation are worked out in this paper. The achieved data rate, the spectral efficiency and the bit error rate (BER) represent validation parameters on which the results of the analytical and simulation models are evaluated. It is concluded that the application of the digital OFDM modulation in the maritime VHF band may improve the GMDSS system by achieving higher data rates compared to the current terrestrial mandatory systems for data exchange, i.e. Digital Selective Calling (DSC) and AIS.
ORALLY SWEETENERS BY SUCROSE 35% AND DEXTROSE 35% TO THE LEVEL OF PAIN DURING VENIPUNCTURE
Authors: Kusumaningrum Arie
Published: July 2018

Introduction. Insertion a needle on the skin layer structure will impact to the neural responses of pain sensory receptors what make a pain’s sense to baby and make them would cry, struggle and irritable. That were inhibit the invasive process and aggravate the trauma in infants because of repeated procedures and hormonal responses that increase pain. The objective of this research was to know how difference orally sweetener administered by sucrose 35% and dextrose 35% to the level of pain during venous puncture. Method. There were three group in this study, the first one was the experimental group received oral treatment of 35% sucrose, the second was received 35% dextrose, and the last was control group. Data were analyzed by Mann Wheatney and Kruskal Wallis test. Results. The results showed there is no difference pain scale in control groups, sucrose 35% and dextrose 35% (p = 0.09). Discussion. There was lower pain in dextrose 35% group than the control group (mean = 5.8 to mean: 5.6). It was recommend for further investigation with a larger sample and measuring pain scale appropriate to the mice. Keywords: orally sweeteners, sucrose, dextrose, vein
BALANCE EXERCISE TO POSTURAL BALANCE IN ELDERLY AT PTSW KASIH SAYANG IBU, BATUSANGKAR
Authors: Lazdia Wenny , Amelia Sherly , Silviani Silviani
Published: July 2018

Introduction. Elderly are the age group most at risk of impaired postural balance due to declining elderly or morphological changes in the muscles that cause functional changes in muscle strength and decreasing muscle contraction. Decreasing in postural balance due to decreased muscle strength can be improved by doing exercises that are useful to keep the muscle function and posture remains well one of them is balance exercise. The purpose of this study was to analyze influence of balance exercise to postural balance on elderly in PTSW Kasih Sayang Ibu Batusangkar. Methods. This research used a pre - experimental design one group pre - post test design with One Group Pre - Post Test Design. Population and sample of the study was elderly with impaired postural balance that met the inclusion criteria by using were purposive sampling techniques they were 41 respondents. This study was conducted from July to September 2013 in PSTW Kasih sayang Ibu Batusangkar. Measuring instruments used in this study is a questionnaire for the elderly demographic data and tools to measure the level of the elderly postural balance sheet observation Berg Balance Scale. Results. While the results obtained from the significant influence of postural balance elderly before and after exercise balance with p value 0.000 with a mean difference of 8,171. Discussion. Elderly with postural balance disruption suggest to do balance exercise to keep dynamic and static stability, so can increase quality of life. Keywords: Balance Exercise, Postural Balance, Elderly
CLASSROOM SIMULATION METHOD INCREASES NURSING STUDENT FAMILY-FOCUSED CARE COMPETENCIES IN FAMILY NURSING LEARNING PRACTICE
Authors: Kiik Stefanus Mendes , Mahathir Mahathir , Prasetyono Juli Dwi
Published: July 2018

Nursing is a professional field that requires formal education and institutional learning experiences in acquiring specific expertise. Family nursing is one of the core science in nursing education that requires a specific approach in order to build a professional nurse-family relationship. Family-focused care education demand a broader understanding in providing care of  the family as a unit system by the students to meet the family needs. Educators should choose effective and creative learning methods in teaching the important component of family-focused care. Classroom simulations is a method that considered to be able to accommodate the achievement of cognitive, psychomotor, caring and nursing process. This study was conducted to identify the effectiveness of classroom simulation learning methods to student family-focused care competencies using family-focused care competency assessment by Van Gelderen rubric. This research was conducted by quasi experimental pre and post with control group design. The sample size is done by hypothesis test two pairs population (numeric data) formula. The study was conducted on 34 respondent as a sample that showed significance increasing of the mean value after classroom simulation Man Whitney test (p = 0.000). It is sugested the application of clasroom simulation learning methods before the students perform nursing practice directly to the family. Van Gelderen rubric is an instrument which is able to assess the competence of family-focused care.Keywords : Simulation, classroom simulation, nursing education, family nursing, family-focused care.
PSYCHOPOETRY THERAPY MODEL TOWARDS ENHANCING COGNITIVE'S INSIGHT CLIENTS ON MENTAL DISORDERS IN PSYCHIATRIC HOSPITAL
Authors: Hendriani Yeni
Published: July 2018

Introduction. Cognitive's insight is an important aspect in determining the diagnosis and treatment programs to clients with mental disorders. Psychopoetry therapy as an intervention modality based on the reading and writing of poetry those are expressive of the feelings of the client. Purpose of this study was to determine the effect of therapy models psychopoetry to measure themselves in the improvement of cognitive (self-assurance component) on the client's mental disorder. Benefits psychopoetry therapy as a means of expressing feeling depressed clients and are thought to contribute to the problem at hand. Method. The research method was used quasi-experimental research design with non-randomized pretest-posttest control group. Result. The results of this research were significant changes in the intervention group before and after treatment, and when compared with the control group (p < 0.05). Discussion. Psychopoetry therapy model can be used in addition to other therapeutic nursing interventions that have been implemented. This model is able to optimize the ability to build the structure of phrase in communication and recommended the development of writing skills productively. Keywords: Psychopoetry therapy, insight, cognitive, modification, expressive
COACHING: RGO (RENDAM GOSOK OLES/SOAK RUB TOPICAL/SRT) ON THE SELF CARE LEVEL OF LEPROSY CLIENTS
Authors: Susanto Tantut , Wantiyah Wantiyah
Published: July 2018

Introduction. Physical problems of leprosy clients such as leprosy wounds and disability resulting negative publicperception (stigma) for the clients. The purpose of this study was to analyze the effect of the intervention Coaching: RGOto the level of self-care of leprosy clients. Method. This study used an experimental design with one group pretest andposttest. The study was conducted during one month in leprosy clients undergoing rehabilitation through community.Eighteen (18) leprosy clients in Puskesmas Tempurejo and Jenggawah selected as respondents using simple randomsampling. Result. The results showed that the level of self care before the RGO intervention the majority (83.3%) ofclients was dependent. After the intervention, the majority of clients (61.1%) experience independence on performingself care. Analysis using frequency distribution and kendall 's tau showed the effect of coaching on the level of self-careindependence of the leprosy clients (p 0.000; α 0.05). Discussion. Leprosy clients require a gradual and regular exercisetwice daily in the treatment of eyes, hands, and feet by doing soak, rub, and topical to prevent the disability.Keywords: Coaching, Leprosy, community-based rehabilitation
THE VARK LEARNING STYLE OF NURSING AND MIDWIFERY STUDENTS
Authors: Sinaga Janno , Siregar Rinco , Amila Amila , Sembiring Rinawati
Published: July 2018

Introduction. VARK is very important to facilitate the development of nursing and midwifery students, helping translate theory into practice, and making what is learned in the classroom a reality. It is important to assess the learning style ofstudents to cater for differing learning needs. The aim of the study were: 1) to identify learning style nursing and midwifery students, and 2) the differences of learning style between nursing and midwifery students. Method. A descriptive crosssectional study was performed by using VARK questionnaire version 7.8. A total of 241 students including 125 nursing and 116 midwifery students were participated in this study that selected using stratifi ed random sampling techniques. Data analysis used Chi square test and One Way ANOVA (α=0.05). Result. The study showed that 61.7% and 67.8% nursing and midwifery students in the fi rst year; 70.8% and 63.3% in the second-year were used multimodal learning preferences, respectively. There was no signifi cantly differences learning preferences between the fi rst and the second-year as well as between nursing and midwifery students (p>0.05). Discussion. The nursing and midwifery students have varies on the learning preferences however the majority of the students used multimodal. Therefore, an active learning method was recommended. Keywords: Learning style, Nursing and midwifery students, VARK
OLD BEMORALTY (OLDER COMMUNITY BEING MORE HEALTHY) IMPROVEMENT EFFORTS THROUGH INDEPENDENCE ELDERLY POSYANDU BASED ON HIERARCHICAL CLASS SYSTEM OF ABRAHAM MASLOW
Authors: Hasinuddin M. , Yulianto Sofi , Suhron M.
Published: July 2018

Introduction. Aging is a natural process in humans is accompanied by a decrease in the physical, psychological and social which interact with each other is known as the elderly. The purpose of this study was to determine the effectiveness of the Elderly Posyandu using Abraham Maslow hierarchy of the class system of the elderly independence. Method. The design of this study was quasy experiment with post-test only with control group design. Data collection was performed using the independence of elderly people who modifi ed checklist sheet of cards to health (KMS) elderly and then test hypothesis test using independent t test with signifi cance level 0.05. Results. Statistical analysis showed the independence of the elderly for the treatment group obtained a mean value of 75.4615 and 60.8462 of the control group. Normality test as a condition of the t test showed the two groups has a normal distribution so as to know the difference between the independence of elderly people treated group and the control group were tested using independent t test with p value = 0.001 results < α (0.05). There was a difference in elderly independence between the treatment and control groups. Discussion. Need for innovative program to improve the independence of the elderly through the integration of health services through Posyandu modifi ed by taking into account the biological, psychological, social, and spiritual based class Maslow hierarchy. Keywords: Elderly, Posyandu, independence, Maslow
SELF-CARE AGENCY TO ELDERLY WITH RHEUMATOID ARTHRITIS BASED ON THEORY OF DOROTHEA E. OREM
Authors: Prawesti Dian , Christiawan Jefri
Published: July 2018

Introduction. Elderly who experience rheumatoid arthritis, if elderly with rheumatoid arthritis is not treated immediately, they will lead self-care defi cit. The objective was to describe self-care agency to elderly with rheumatoid arthritis based on theory of Dorothea E Orem. Methods. The research design was descriptive. Population was all elderly with rheumatoid arthritis at Kelurahan Bangsal Kota Kediri. The subjects were 55 respondents using purposive sampling. The variable was self-care agency. Data collecting used questionnaires of Denyes Self-Care Agency-90, then analyzed used statistical test of frequency distribution. Result. Results of self-care agency to elderly with rheumatoid arthritis was good (56.4%) consisted of ego strength aspect, was good (56.4%), aspect of health value was good (56.4%), aspect of health knowledge and decision making was good (61.8%), energy aspect was poor (50, 9%), feeling aspect was poor (58.2%), attention to health aspect was good (50.9%). Discussion. Elderly with rheumatoid arthritis have good self-care agency which consist of good in ego strength aspect, good health knowledge and decision making aspect, good attention to health and poor in energy and feeling aspect.Keywords: Self-care agency, elderly, rheumatoid arthritis
Efficient Prediction of Structural and Electronic Properties of Hybrid 2D Materials Using DFT and Machine Learning
Authors: Tawfik Sherif , Isayev Olexandr , Stampfl Catherine , Shapter Joseph , Winkler David , Ford Michael J.
Published: July 2018

Materials constructed from different van der Waals two-dimensional (2D) heterostructures offer a wide range of benefits, but these systems have been little studied because of their experimental and computational complextiy, and because of the very large number of possible combinations of 2D building blocks. The simulation of the interface between two different 2D materials is computationally challenging due to the lattice mismatch problem, which sometimes necessitates the creation of very large simulation cells for performing density-functional theory (DFT) calculations. Here we use a combination of DFT, linear regression and machine learning techniques in order to rapidly determine the interlayer distance between two different 2D heterostructures that are stacked in a bilayer heterostructure, as well as the band gap of the bilayer. Our work provides an excellent proof of concept by quickly and accurately predicting a structural property (the interlayer distance) and an electronic property (the band gap) for a large number of hybrid 2D materials. This work paves the way for rapid computational screening of the vast parameter space of van der Waals heterostructures to identify new hybrid materials with useful and interesting properties.
TEMBANG DAN MODEL PENGAJARANNYA
Authors: Sulanjari Bambang
Published: July 2018

The major of Tembang is a small partof theconstellation ofthe Java languagecurriculum that included in theclumps. Due toaless strategicposition, thismajor is often overlooked,butiffurtherexplored,this major is so potentialtodevelop thecharacterof students. At least, tembang can be utilizedmosteffectivelytodevelop thefourlanguage skills: listening, reading, writingand speaking.Competenciescan be developedin thetembanglearningof them arethe studentsable tosing thesong, phrasing thesongandmakesong.Learningmodel selectionis crucial in thesuccess oftembanglearning. Creativityof teachersin selectingandimplementinglearning modelis very influentialon the success oftembanglearning, therefore teachersmust be creativeto determine the modelaccordingto the circumstances. In terms ofsongselection ofteaching methods, teachers can developmethods that areinheritedancestors, such asmethods of learningwith playing, the method of learningwith moving, step bystepmethod, andkaraoke method.
PENGEMBANGAN SENAM AEROBIK KIDS UNTUK MATERI PENDIDIKAN JASMANI OLAHRAGA DAN KESEHATAN SISWA SEKOLAH DASAR
Authors: Fahmi Donny Anhar
Published: July 2018

ABSTRACTIn the process of study in physical education,sport, and health for elementary school student, aerobic gymnastic is can used as one of matery in rhitmic activity for V class. Will hoped to add the variety in physical education,sport, and health material which limited variety. This research becomes the development f the research it self. The procedures of this research which is used consist of the analysis of product which is developed, to improve product earlier, the expert validation, the field trial, consist of the small groupt test and the big group test, product revision, and the development product resultThe research result is a product model for aerobic gymnastic can be used as media learning of physical education,sport, and health. Based on the scale wide test to the product, the using of aerobic gymnastic model to the student, it can increase the pulse for about 62% from 120 student. From the response which is given to 120 student to the psycomotor aspect which including in a good category as much as 94 student, middle category as much as 23 student, and low category as much as 3 student. For Cognitive aspect including a good category as much as 81 student, middle category as much as 34 student, and low category as much as 5 student. Affective aspect which including good category as much as 88 student, middle category as much as 26 student, and low category as much as 6 student.Based on the researh result which is concluded?é?á: (1) The development of aerobic gymnastic model for learning physical education,sport, and health elementary school students can be increase physical activity student in learning. Improvement pulse rate that happened of students until 62 %. This matter is knowable from means of pulse rate before learning aerobic gymnastic is 93 times a minut, and experiencing of improvement until 150 times a minut after following learn aerobic gymnastic. (2) The student is very intersting and feels happy with the aerobic gymnastic model which is thaugt so that the student can move effectively in learning implementation.?é?áKeyword: Development, Aerobic Gymnastic, Physical Education, Elementary School Student.