bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacist Effect on Discharge Follow-Up Education in Pediatric Oncology Outpatient Clinics: A Quality Improvement Study
Authors: Drennan Chelsea N. , Pauley Jennifer L. , Christensen Anthony M. , Jacobs Timothy W. , Bragg Allison W. , Porter Jerlym S. , Bourque Melissa S.
Published: June 2023

OBJECTIVE

We aimed to describe the effect of education provided by a clinical pharmacy specialist at a patient's follow-up appointment after discharge, and to assess caregiver satisfaction.

METHODS

A single-center, quality improvement study was conducted. A standardized data collection tool was created to characterize interventions made by clinical pharmacy specialists during an outpatient clinic appointment scheduled shortly after discharge. Pediatric patients with cancer who met the following criteria were included: 1) initial diagnosis without receiving chemotherapy, 2) first course of chemotherapy after initial diagnosis or relapsed disease, and 3) post-hematopoietic stem cell transplantation or cellular therapy. A survey was provided to families after the follow-up discharge appointment to assess the caregiver's satisfaction of the new process.

RESULTS

From January to May 2021, a total of 78 first-time discharge appointments were completed. The most common reason for follow-up was discharge after first course of chemotherapy (77%). The average duration of each appointment was 20 minutes (range, 5–65). The clinical pharmacy specialist made an intervention during 85% of appointments. The most common intervention made during the visit was reinforcement of medications (31%). Thirteen surveys were completed by caregivers; 100% of the caregivers reported the follow-up appointment was helpful. Additionally, they reported the most useful resource provided at discharge was the medication calendar (85%).

CONCLUSIONS

Investing clinical pharmacy specialist time with patients and caregiver after discharge appears to have a meaningful effect on patient care. Caregivers report this process is helpful in better understanding their child's medications.
Serflik Sisteminin Gelişimi ve Kulakların Ortaya Çıkma Süreci
Authors: BİLGİLİ Cihan
Published: June 2023

Serf, Rusya İmparatorluğunda kendisine tahsis edilen arazide bir nevi toprak ağası adına çalışan köylüye verilen isimdir. Kölelik sistemine oldukça benzeyen bu sistemde serfler ile özgür köylüler arasındaki farklardan en önemlisi göçme özgürlüğüydü; serfler efendilerinin izni olmadan topraklarını veya köylerini sürekli olarak terk edemiyorlardı. Bunun dışında evlenmek, iş değiştirmek veya mallarını devretmek için efendilerinden izin almaları gerekiyordu. Toprağa bağlılardı ve toprak el değiştirdiğinde serfler de yeni efendinin hizmetine giriyorlardı. Bu köylüler kanun önünde efendilerine nazaran çok kısıtlı haklara sahiplerdi. Rus köylüsü Moskova Rusya’sından itibaren İmparatorluk ve Sovyetler Birliği dönemlerinde tarım politikasının tam merkezinde yer aldı. 1861 Toprak Reformu sonrasında Rus köylüsünün özgür kalmasıyla serflik sistemi sona erdi ancak 19. yüzyılın sonlarına doğru yeni bir sınıf ortaya çıktı. Dolayısıyla Rus köylüsü kulakların varlığını oluşturan en önemli unsurlardan biriydi. Bu iki sınıf arasındaki ilişki onların nasıl bir düzen içinde var olabildiklerini göstermesi açısından önemlidir. Bu araştırmada hem yüzyıllarca süren serflik sistemindeki Rus köylüsünün durumunun ortaya koyulması hem de Toprak Reformu sonrasında kulakların ortaya çıkış sürecinin tarihsel bağlamda değerlendirilmesi amaçlandı. Bu araştırmada hem yüzyıllarca süren serWlik sistemindeki Rus köylüsünün durumunun ortaya koyulması hem de Toprak Reformu sonrasında kulakların ortaya çıkış sürecinin tarihsel bağlamda değerlendirilmesi amaçlandı.
Hikikomori Öz Bildirimi için Uyarlanabilir Davranışlar Ölçeğinin Türkçeye Uyarlanması
Authors: İLİC Ulaş
Published: June 2023

Günlük hayatımızda insanlara birçok açıdan yardımcı olan dijital cihazlar sınırsız kullanımları nedeniyle insanlarda çeşitli psikolojik sorunlara yol açmaktadır. Hikikomori de bu problemlerden biridir. Bireyin sosyal hayatından 6 aydan uzun süre kendini çekmesi olarak tanımlanan kavram hızla çoğalmaktadır. Bunun için de sosyal hayatın her unsurunu etkileme potansiyeli büyük olan bu kavramı belirlemek önemlidir. Kavramı değerlendirmeye yönelik Türkçe dilinde bir araç bulunmamaktadır. Söz konusu nedenle bu çalışmada Hikikomori Öz Bildirimi için Uyarlanabilir Davranışlar (HÖBUD) Ölçeğinin Türkçeleştirilmesi amaçlanmıştır. Ölçek uyarlamanın çeviri sürecinin dil geçerliliği aşamasında altı uzman ile sekiz öğretmen adayı katkı sağlamıştır. Doğrulayıcı faktör analizi adımına ise 305 kişi katılmıştır. Veri toplama aracı Nonaka ve Sakai’nin (2022) geliştirdiği ölçeğin Türkçeleştirilmiş formudur. Süreç 2022-2023 öğretim yılı bahar döneminde yürütülmüştür. Elde edilen veriler analizi için doğrulayıcı faktör analizi kullanılmış ve ölçek Türkçeye uyarlanmıştır. HÖBUD ölçeğinin özgün ölçekteki dört faktör 26 maddelik yapısı doğrulanmıştır (χ2/df= 3,09, p
Real Options and their application in renewable energy projects. State-of-the-art review
Authors: Murgas Téllez Benjamín , Henao-Pérez Alvin Arturo , Guzmán Acuña Luceny
Published: June 2023

The use of renewable energy sources, such as wind, solar, among others, has been growing, especially in recent years. The main objective of this study was to conduct a literature review on the real options approach for assessing the feasibility of investing in energy production and its derivatives. Thirty publications on the mentioned topic were analyzed using the Mendeley Reference Manager bibliographic software and categorized into seven groups according to their purpose: 1) Evaluation of renewable energy projects or investments, 2) Evaluation of non-renewable energy projects or investments, 3) Evaluation of energy auctions, portfolios, and investments in the energy market, 4) Evaluation of renewable energy technologies, 5) Evaluation of the impact of regulatory policies on renewable energy projects, 6) Evaluation of the transition to renewable energy generation, and 7) Evaluation of the design, size, and location of wind farms. Nine types of options were identified: 1) Waiting, 2) Delaying, 3) Anticipating, 4) Expanding, 5) Exercising, 6) Rejecting, 7) Abandoning, 8) Expanding, and 9) Switching. Additionally, the techniques and models applied to evaluate the options and simulate the twenty-nine uncertainties, grouped into eight categories, considered in the research were examined. In the future, there is a need to increase studies using the real options approach to evaluate renewable energy projects under uncertainties, applying new evaluation techniques that allow for the valuation and establishment of flexible strategies.
Macro analysis of Maruzen foods (Thailand) co.,ltd.
Authors:   , Zhong Kuangjie
Published: June 2023

Macro analysis is kind of research method which takes the whole economic activities as the research object, mainly studies the changes of GDP, social employment, and economic development. Macro analysis reflects a lot of valuable information of economy.

In this report, we firstly analyze the global economy, it consists three parts: general information in 2019, the influence of trade war on global economy, and economic trend in 2020. Then we focus on the overview of the economy in Thailand, such as GDP in 2019, export and import value of major product, employment by industry, and economic trend in 2020. In addition, we analyze the economic conditions in Northern Thailand, especially the northern region’s economic conditions. Finally, since Maruzen Foods (Thailand) Company Limited is a Thai-Japan company, we also analyze the Japan economy.

According to the macro analysis, it provides macroeconomic information to the organization or the firm to design the development strategy of maximizing benefits. And it can improve the core competition of Maruzen.
Marketing analysis of Fu Anna Home Textile co., ltd.
Authors:   , Lin Jue
Published: June 2023

With the rapid development of China's national economy, the domestic consumer goods market is growing prosperous. At the same time, the home textile industry is showing a thriving scene. However, it is also facing a crisis of increasing complexity in the living environment. Therefore, if a company wants to gain a comparative advantage in the existing objective environment, it needs to formulate a strategic plan suitable for the current situation and enhance its core competitiveness.This research takes the marketing strategy analysis of Fu Anna household products Co., Ltd. as the theme. It will analyze the external and internal environment of Fu Anna, First of all, this research will analyze company management and business model. Then uses SWOT analysis to examine the external and internal environment of the company and obtains the strategic management options suitable for the company. We conclude that the company needs to reformulate its competitive strategy. It is, first, maintain product differentiation and innovationt. Second, expanding marketing channels and keep low prices. Finally, improving the company's core competitiveness in an all-around way in the fierce competition.
Marketing strategy analysis of Laogai home textile company
Authors:   , Liu Yang
Published: June 2023

This paper takes Luolai Home Textile Company as the research object. Firstly, it introduces some relevant backgrounds of China's domestic home textile market to determine its great development space. Then it analyzes the marketing environment of Luolai Home Textile Company and its existing marketing strategy by mainly using the PEST theory, SWOT analysis method, and 4Ps theory. Through analysis of the marketing environment, it is found that the external marketing environment of Luolai Home Textile Company is healthy, which is conducive to its development. However, by combining the analysis of Luolai’s internal marketing environment and its existing marketing strategies, it is found that Luolai is facing a fierce industry competition, especially the competitive pressure from several other large-scale home textile companies in China. In order to continue to maintain its leading position in China's home textile industry, Luolai Home Textile Company should improve its existing marketing strategies. For example, it is necessary to improve marketing strategies in accordance with the latest national policies, adapt to changes in society and changes in customer requirements, and pay more attention to e-commerce.
Research on the development strategy of cross-border e-commerce of Netease Kaola Overseas shopping in China
Authors:   , Chen Yi
Published: June 2023

In the rapid growth of cross-border e-commerce, China Kaola Overseas Shopping Platform adopts the developed model of "foreign warehouse + domestic bonded warehouse", which has become an important part of the current cross-border e-commerce field in China.  However, it still suffers from poor after-sales service, uninsured processes and poor consumer perception during delivery.  This paper takes China's Kaola Overseas Shopping Platform as the research object, comparing to other similar platforms in the industry, and analyzes its cross-border e-commerce business by using "SWOT", "PEST" and "Five Forces Model". This results show how the company adjust its strategies to solve the current problems. I find that in the process of cross-border e-commerce transactions, payment methods, logistics transportation and service personnel directly affect the quality of cross-border e-commerce operation, and have a great impact on its services.  Although Kaola has certain advantages in technology, there are still problems in after-sales service, logistics and consumer perception. The solutions proposed in this paper are to establish the professional after-sales team, to cultivate consumer awareness, and to optimize cross-border logistics.
Freiheit und Finanzen vor Frauen?
Authors: Rockenbauch Uli
Published: June 2023

Beim Thema Finanzen ziert sich die Politik nicht, die Wissenschaft auch einmal hart zu sanktionieren, falls nötig.
Der lange Weg zum Luftschloss
Authors: Rockenbauch Uli
Published: June 2023

Alle sind sich einig, dass die Forschung mehr Freiheiten braucht, um schneller und innovativer zu werden.
Mehr Einsicht, bitte
Authors: Rockenbauch Uli
Published: June 2023

Was wir oft ausblenden: Durch Informationsfreiheitsgesetze sind viele unserer Hochschulen zur Offenlegung ihrer Akten verpflichtet, wenn Bürger*innen es einfordern.
Dialogue and monologue in social media
Authors: Grieve-Smith Angus
Published: June 2023

I wrote most of this post in June 2022, before a lot of us decided to try out Mastodon. I didn’t publish it because I despaired of it making a difference. It felt like so many people were set in particular practices, including not reading blog posts! My experience on Mastodon has been so much better than the past several years on Twitter.
Imagining an alternate language service
Authors: Grieve-Smith Angus
Published: June 2023

It’s well known that some languages have multiple national standards, to the point where you can take courses in either Brazilian or European Portuguese, for example.
Fonts for Stokoe notation
Authors: Grieve-Smith Angus
Published: June 2023

You may be familiar with the International Phonetic Alphabet, the global standard for representing speech sounds, ideally independent of the way those speech sounds may be represented in a writing system. Did you know that sign languages have similar standards for representing hand and body gestures?
“Behind the Science” pausiert
Authors: Rockenbauch Uli
Published: June 2023

“Behind the Science” pausiert
The Impact of Education System on Economic Growth: An Empirical Evidence from Developing Economy
Authors: Majid Khan  , Kiran Sarwar  , Gul Rukh Niazi
Published: June 2023

The role of education in economic growth levies a massive impact on the economic growth of developing countries. This study has investigated the outcome of the education system on economic growth in the context of Pakistan. This study has also considered the literacy rate, labour force, consumer price index and unemployment for analyzing their shade on the growth of our country. The gross domestic products of the country have shown dependency in our model. In the light of regression analysis, results are helpful for a literature review that illustrates that role of education positively affects the growth of a country and freedom of economy is a sophisticated way to check the prominence of the growth of the economy.
The Impact of Active Engagement and Independent Critical Thinking in Modeling Managerial Behavior with Mediating Effect of Leader-member-Exchange
Authors: Muhammad Siffat Shah
Published: June 2023

The current study aims to determine the mediating role of leader-member exchange (LMX) on the relationship between followership dimensions (active engagement and independent critical thinking) and transformational leadership. Survey approach was used. Cross-sectional primary data was collected from employees of banking and telecom sector. Total 215 respondents participated in the survey. Non-probability sampling technique was used. Findings revealed that there was positive and significant association found between active engagement (AE), independent critical thinking (ICT), leader-member exchange (LMX) and transformational leadership (TFL). Furthermore, LMX partially and significantly mediates between AE, ICT and TFL relationship. It is concluded that leaders have to build good working relationship with their followers and these relationship must be based n trust, respect and loyalty.
Reflexiones sobre el concepto de Turismo Sostenible y su integración en el actual contexto sociopolítico ecuatoriano
Authors: Hernanz Iris Martín , Martín Gil Fernando
Published: June 2023

En las últimas décadas el Turismo Sostenible, ha tenido una amplia acogida en la política internacional, regional y nacional. Sin embargo, en la mayoría de las ocasiones apenas ha existido una reflexión sobre cuál debe ser el enfoque a seguir, ni una definición sobre sus objetivos y principios. El artículo plantea una reflexión en torno al Turismo Sostenible, partiendo del estudio sobre la evolución del Desarrollo Sostenible, el análisis teórico sobre el concepto y una revisión de documentos internacionales y sus principales aportaciones. Asimismo se analiza la integración del Turismo Sostenible en el contexto sociopolítico actual de Ecuador definido por la Constitución de 2008, el Plan Nacional del Buen Vivir y, de forma específica, el Plan estratégico de desarrollo de turismo sostenible para Ecuador.
Fabrication, Performance Test and Efficiency of Electrical Energy of Dye Sensitized Solar Cells (DSSCs)
Authors:   Tai Solarin University of Education, J. D. Ayanda , O. O Odumosu ,   Tai Solarin University of Education, A. D Adelaja ,   Federal University Kashere, A.A Adetona ,   Tai Solarin University of Education
Published: June 2023

Dye-Sensitized Solar Cells (DSSCs) were fabricated with three naturally occurring anthocyanin dyes extracted from naturally occurring seeds found in western African viz: raspberry, blackberry, pomegranate seeds as sensitizers. Extraction of anthocyanin was done using acidified ethanol. The highest power conversion efficiencies (η) of 0.3 % was achieved for the DSSCs fabricated using anthocyanin extracts of the seeds. The widespread availability of these seeds, high concentration of anthocyanins in them, and ease of extraction of anthocyanin dyes from these commonly available seeds render them novel and inexpensive candidates for solar cell fabrication. This study also synthesized conductive transparent glass as a substrate on which fabrication of solar power panels which after production is expected to generate <0.1 KvA to demonstrate the importance of these Soda Lime Glass (SLG). Twelve (12) Solar cells of averagely 300 mV and 0.02 A were fabricated. Equivalently these cells gave 3.51 volts averagely as peak voltage during the day and 2.08 volts as the lowest voltage during the lowest temperature. Although there were voltage variations when compared with standard silicon solar cells, the production could be improved upon if other metalloids that are economical are used for the production, or by increasing the number of cells.
Interactive Health Information Chatbot for Non-Communicable Diseases in Swahili Language
Authors:   Kampala International University, Rajabu Neema
Published: June 2023

Current health awareness campaign strategies, efforts, and methods on NCDs have not produced improved outcomes in reducing the burden, spread, and deaths linked to NCDs in Tanzania. To support, compliment, and improve health literacy on NCDs and promote good healthcare, we designed and developed an interactive health Chatbot ‘afyaBot’ in Swahili language that can respond to user's requests concerning NCDs symptoms, prevention, management, and cure. The Chatbot was designed using Botsociety; a special tool for designing Chatbot prototypes; BotMan framework for coding the Chatbot logic and Google Dialogflow platform that offers high-level Natural Language Processing capabilities. The Chatbot was integrated into the Facebook Messenger platform which offers free public API access that eliminates the cost of the internet from the consumers. The Chatbot was tested for accuracy, usability, user experience, responsiveness, reliability, maintainability, and portability. The results of implementation were satisfactory and provide insights useful to stakeholders in the health sector. The interactive Chatbot was designed to provide real-time information on NCDs, create awareness, and educate users on preventive, control, and treatment measures of NCDs. It will likewise assist healthcare providers to collect accurate timely health data for monitoring, planning, and research purpose.
Analysis and Design of File Tracking System
Authors:   Yobe State University, Mohammed Bala Usman , Muhammad Muhammad Musbahu ,   Asad Pharmaceuticals Limited
Published: June 2023

The file tracking system has been one of the areas of concern in most of our organizations. Much research over the years has been carried out to tackle the problem of file monitoring system in our institutions. As we all know large volumes of data are usually generated in most institutions of learning today. Locating files using the manual method is a tedious and time-consuming process for most of our administrative staff of such institutions. This paper aims to analyze and propose a file tracking system that will eliminate the problem caused by the manual system of a file monitoring system. This can be achieved by interviewing the staff who is in charge of the file monitoring system in the institution. The proposed system was designed based on the information gathered from staff using UML diagrams such as use case diagrams and easy designer to create a database diagram. Which helps in managing the flow of files effectively and efficiently. All the files such as reports, decisions, requests, and location history can be processed and tracked by the system at any period.
ACCOUNTING SOFTWARE AND QUALITY OF CORPORATE REPORTING IN PROFIT ORIENTED COMPANIES
Authors:   Babcock University, OLUBUNMI ALAO , FOLAJIMI FESTUS ADEGBIE ,   Babcock University
Published: June 2023

Tracking the various business parameters variables related to the business’s goal is a difficult task to do without the right tools. Failure to properly put in place accounting processes that oversee and manage such parameters has led to the demise of many promising small and big organizations. This work looks into how the use of accounting software affects the quality of reporting while focusing on the tools and application modules that make the process hitch-free. Because of the lack of local data and feedback from first-hand operators of accounting software, the study infers knowledge from other works on the effectiveness of accounting software in organizational reporting. It also looks into the tools that come with Microsoft Excel, one of the most widely used accounting software in Nigeria. We make use of sales data gotten online to implement this tool and the result shows that the Microsoft Excel application is capable of minimizing errors, automating tasks, and forecasting. By making use of Excel Solver, we were able to determine the percentage of the baby food product that must be sold at the highest price to maximize profit. the solution model shows that at the lowest forecast rate of 67%, the organization will make $163,875,000.00 and $180,000,000.00 at 100%. The study concludes that accounting software is critical to the overall well-being of corporate organizations in Nigeria as it brings about a profound ease of corporate accounting processes
OCCUPATIONAL HAZARDS PREVALENCE AND AGRICULTURAL WORKERS’ JOB PERFORMANCE OF AGRICULTURAL ORGANISATIONS IN OYO STATE, NIGERIA
Authors:   Federal University of Agriculture, Abeokuta, Nigeria, Fapojuwo Oluwakemi , Ajayi Michael Tunde ,   Federal University of Agriculture, Abeokuta, Nigeria, Okubena Babatunde Adeoye ,   Federal University of Agriculture, Abeokuta, Nigeria, Adebayo Olaoluwa Ayodeji ,   Federal College of Wildlife Management, Forestry Research Institute of Nigeria, New-Bussa, Niger State, Nigeria., Fapojuwo Temitope Obatobi ,   Federal Medical Centre, Abeokuta, Nigeria
Published: June 2023

Occupational hazards occurrence is one of the major determinants of agricultural workers job performance which could lead to intentions to quit, absenteeism, low commitment and productivity in the workplace. The study assessed and test the association of the occupational hazards prevalence and agricultural workers’ job performance of agricultural organisations in Oyo State, Nigeria. The data collected was primary and cross-sectional. A simple random sampling technique was used in selecting 128 participants in the study area. The results revealed that the mean age of the agricultural workers was 36 years while their average monthly income was ₦ 82,175.22 and years of work experience was 10.47 years. The prevailing occupational hazards include falls, slips and trips on muddy surfaces (x̅= 3.54), back pain/general body pain while repeatedly bending over to work (x̅= 3.44) and working in an environment full of sharp objects (x̅= 3.43). Occupational hazards are often prevalent (x̅= 4.15). The agricultural workers are high job performers (x̅= 4.22). Pearson Product Moment Correlation showed that at p < 0.05, occupational hazards prevalence (r = -0.47) significantly associates with agricultural workers’ job performance in the study area. Based on the results of the study, it was recommended that agricultural organisations should train and re-train their agricultural workers periodically on occupational safety and health at work. This will reduce the occupational hazards stumbled upon by the agricultural workers thereby increasing their job performance.
EFFECT OF DIGITAL ADVERTISING ON CONSUMER BUYING BEHAVIOUR IN LOKOJA METROPOLIS
Authors:   Kogi State University, Anyigba, Nigeria, Sulaiman Olusegun , Yusufu Ojochenemi Sunday ,   Kogi State University, Anyigba, Nigeria, Sadiq Hajarat ,   Kogi State University, Anyigba, Nigeria
Published: June 2023

Digital advertising plays an imperative role to stimulate consumer preferences, build a positive consumer attitude and influence consumer buying behaviour about the products and services offered in advertisements. The level of development in digital advertising has had a dramatic change on the conduct of business in this era of globalization. Businesses today embrace the use of digital advertising without adequate attention to salient issues concerning the digital advertising platforms and information that can affect consumer buying behaviour. Thus, this study was designed to: (i) examine the effect of digital advertising platforms on consumer buying behaviour in Lokoja metropolis; (ii) determine how digital advertising information affect consumer buying behaviour in Lokoja metropolis. The study used descriptive survey design. The population of the study comprised of customers in Lokoja who make online shopping. The entire population of Lokoja is 195,520 as at 2006 census. Using Yaro Yamani formula, a sample size of 399 respondents were selected for the study. Simple random sampling technique was used to select the respondents. Data were collected through structured questionnaire. Correlation and regression analysis were employed for the analysis at 0.05% significant level. The findings of the study showed that there was a statistically significant correlation with r = 0.973 at significant level of 0.001. The second hypothesis showed that digital advertising information has a significant effect on consumer buying behaviour with r = 0.887 at the significant level of 0.000. The study concluded that the online update information, digital message coding, social media platform information and buyers’ patronage information affect consumer buying behaviour. The study commended that management of the organisations and other businesses must develop a strategy that would fully embrace digital advertising as a promotional mix in the marketing of their products to the digital populace.
THE EFFECT OF CAPITAL STRUCTURE ON MANUFACTURING FIRMS PERFORMANCE IN NIGERIA
Authors:   Federal University Oye-Ekiti, Nigeria, Adesunloro Babalola Rapheal
Published: June 2023

The main objective of this study was to examine the effect of capital structure on firm’s performance in Nigeria, using correlation and regression analysis. The study revealed that capital structure exert positive effect on profitability in Nigerian manufacturing firms, this implies that for a percentage increase in capital structure lead to 0.9 percent increased profitability. The study also revealed that capital structure exerts negatives effect on liquidity in Nigerian manufacturing firms; this implies that for a percentage decrease in capital structure lead to 20 percent decreased liquidity. The study concludes that capital structure has positive effect on firms’ performance in selected Nigerian manufacturing firms during the reviewed period. The study also revealed that capital structure exerts negatives effect on liquidity in Nigerian manufacturing firms; this implies that for a percentage decrease in capital structure lead to 20 percent decreased liquidity. The study concludes that Nigeria Manufacturing companies should relying less on liquidity and more on equity as a source of finance to boost their firm performance. The result the study recommended that Manufacturing firms should chose the most optimal capital structure, as it is the profitability that best maximizes firms value, also Manufacturing firms should encourage the use of long term debt in there capital structure since it has positive impact.
EFFECT OF FORENSIC ACCOUNTING TOOLS ON FRAUD INVESTIGATIONS USING BENEISH FRAUD STATEMENT INDEX
Authors:   Federal University, Oye-Ekiti, Nigeria, Babatunde Dorcas Adebola
Published: June 2023

The study examined the effect of forensic accounting tools on fraud investigation using Beneish fraud statement index. Forensic accounting has been pivotal in the corporate agenda after the financial reporting problems which took place in some companies around the world; for example, Enron, Tyco, and WorldCom. These scandals resulted in the loss of public trust and huge amounts of money. Forensic accounting goes beyond fraud prevention but inclusion of marital issues, disputes etc. The study employed Beneish fraud statement index. The M-Score uses eight financial ratios to detect whether a company has manipulated its earnings. The variables were generated from the company’s financial statements and create a score to describe the extent to which the earnings have been manipulated. The M-Score focused on earnings manipulation, the M-Score greater than - 2.22 indicate that the company has maneuverer with its earnings. It needs to be noted that fraud could be handled through three main strategies:; prevention, detection and control .
UNETHICALITY WITHIN THE EGYPTIAN MEDIA
Authors:   American University in Dubai, Heba Alhamarna , Hala Harb ,   American University in Dubai
Published: June 2023

This study examined the unethicality of the Egyptian media in its response by analyzing two cases, including that of an opposing report by Guardian reporter Ruth Michaelson discussing the surging numbers of Covid cases undocumented by the Egyptian Government, as well as a video by a citizen journalist exposing the death of four Covid patients in El Husseineya Central Hospital due to lack of oxygenation. This study aims to examine the responsive coverage to the cases about general ethical analysis approaches in media, including the Potter box with regards to numerous scholars such as Aristotle, Bentham, and Mill. The analysis showed a lack of ethicality within the Egyptian media as they aimed to blur and conceal the truth behind pretenses and create rigid laws prohibiting journalistic freedom. The study also concluded that in both cases presented; the reporting parties presented ethical arguments. Simultaneously, the government and pro-government media outlets were deemed unethical due to their persistence in presenting the public with false reports despite being exposed through numerous incidents and witnesses.
Keragaman genetik cendawan entomopatogen Metarhizium anisopliae (Metsch.) berasal dari tanah pertanaman kelapa sawit berdasarkan penanda RAPD
Authors: Sirait Desianty Dona Normalisa , Tobing Maryani Cyccu , Safni Irda
Published: June 2023

Metarizhium anisopliae (Metsch.) adalah cendawan entomopatogen yang umum menyerang kumbang Oryctes rhinoceros (Linnaeus). Cendawan ini adalah salah satu yang berpotensi dalam mewujudkan pengelolaan hama berkelanjutan karena ramah terhadap lingkungan. Tujuan penelitian ini adalah mengisolasi cendawan M. anisopliae dari berbagai sampel tanah pertanaman kelapa sawit dan melihat keragaman genetiknya berdasarkan penanda random amplification of polymorphic DNA (RAPD). Metode yang dilakukan dalam penelitian ini adalah identifikasi M. anisopliae secara morfologi dan molekuler (ITS), dan pengujian keragaman genetik menggunakan penanda RAPD. Lima belas isolat M. anisopliae berasal dari lima belas perkebunan rakyat kelapa sawit di Sumatera Utara diuji keragaman genetiknya. Berdasarkan karakter morfologinya semua isolat diidentifikasi sebagai Metarhizium sp. Hasil sekuens dengan primer ITS menunjukkan semua isolat M. anisopliae yang yang berasal dari tanah memiliki homologi 85–99% dengan strains M. anisopliae dan M. brunneum rujukan dari database bank gen National Center Biotechnology Information (NCBI). Delapan primer RAPD menghasilkan 39 pita yang mana 38 pita (98,44%) dari pita tersebut polimorfik. Kisaran jarak genetik atau ketidaksamaan genetik antara isolat M. anisopliae adalah 0,051 sampai 0,520%. Analisis pengelompokan RAPD menggunakan metode Neighbour-Joining Tree yang membentuk tiga kelompok.
Transformations of Disgust in Interaction
Authors: Wiggins Sally , Keevallik Leelo
Published: June 2023

Expressions of disgust have typically been studied as isolated faces or voices but rarely as embodied practices in everyday interaction. Building on multimodal interactional research on emotions and sensoriality, this paper addresses disgust as a unique topic at the intersection between psychological theory and interactional facts. A case of an adult enacting post-consumption disgust is analysed, detailing the transformation of the facial, auditory, and embodied expressions across interactional sequences and in collaboration with others. The paper showcases the variability of disgust expressions and their involvement in social actions such as displaying stamina or stoicism toward challenges.
The solid predominant subtype as an independent risk factor for recurrence in patients with pathologic stage I lung adenocarcinoma
Authors: Lee Chul Ho , Jeon Yun-Ho
Published: June 2023

Background: Increasingly many patients have been diagnosed with stage I adenocarcinoma due to the use of low-dose chest computed tomography for lung cancer screening. Therefore, this study aimed to analyze tumor recurrence based on the predominant subtype in patients with stage I lung adenocarcinoma who underwent lobectomy.Methods: We retrospectively analyzed 114 patients who underwent lobectomy for pathologic stage I lung adenocarcinoma from June 2001 to July 2019.Results: In univariate analyses, significant factors were current smoking at the time of surgery (p=0.029), pathologic tumor size (p=0.006), central tumor location (p=0.003), maximum standardized uptake value on positron emission tomography-computed tomography (p=0.001), and the solid predominant subtype (p=0.012). In the multivariate analysis, only the solid predominant subtype (hazard ratio, 9.702; 95% confidence interval, 1.179–79.874; p=0.035) was an independent risk factor.Conclusions: If the solid subtype is predominant in pathologic findings, adjuvant chemotherapy after standard surgical resection may be considered to help reduce the risk of tumor recurrence and increase survival.
La mise en oeuvre des principes de la pédagogie universelle par des enseignantes et des orthopédagogues du premier cycle du primaire dans une perspective de réponse à l’intervention
Authors: Boily Élisabeth , Ouellet Chantal , Thériault Pascale
Published: June 2023

Chaque salle de classe est composée d’une diversité d’élèves ayant des besoins multiples. La réponse à l’intervention (RAI) constitue une approche à paliers multiples qui vise à répondre aux besoins de tous les élèves. La pédagogie universelle s’inscrit dans la même finalité. À cet effet, des auteurs affirment qu’il y aurait plusieurs bénéfices à intégrer davantage la pédagogie universelle et la RAI. Cet article vise à apporter un éclairage sur la mise en relation entre les principes de flexibilité de la pédagogie universelle et la RAI. Il se base sur une analyse secondaire d’une étude portant sur les rôles d’enseignantes et d’orthopédagogues en contexte d’implantation de la RAI. Cet article constitue un premier pas permettant de mieux intégrer ces deux approches en contexte québécois.
Compte-rendu d’une étude empirique portant sur la présence socio-affective des pairs dans une formation en ligne : les étapes de l’analyse des données qualitatives fondée sur l’analyse à l’aide des catégories conceptualisantes
Authors: Proust-Androwkha Sonia
Published: June 2023

Les articles de recherche empirique accordent souvent peu de place à l’explicitation de la phase d’analyse des données; ce manque, qui peut être un écueil pour la compréhension de l’analyse et de l’interprétation des résultats, est en outre susceptible de jeter le doute sur la scientificité de la recherche qualitative exposée. Au vu de ce constat, le présent article se propose de mettre l’accent sur la manière dont a été analysée une partie de nos données empiriques dans le cadre d’une étude qualitative dont l’objectif était d’identifier et de modéliser les perceptions de présence socio-affective de pairs-apprenants dans un contexte de formation en ligne. Il vise précisément à rendre compte du processus analytique mis en oeuvre suivant la méthode d’analyse à l’aide des catégories conceptualisantes, portée par Paillé et Mucchielli (2016).
A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence
Authors: Hachani Abderrahman , Giulieri Stefano G , Guérillot Romain , Walsh Calum J , Herisse Marion , Soe Ye Mon , Baines Sarah L , Thomas David R , Cheung Shane Doris , Hayes Ashleigh S , Cho Ellie , Newton Hayley J , Pidot Sacha , Massey Ruth C , Howden Benjamin P , Stinear Timothy P
Published: June 2023

Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus can persist and replicate within host cells, evading immune responses, and causing host cell death. Classical methods for assessing S. aureus cytotoxicity are limited by testing culture supernatants and endpoint measurements that do not capture the phenotypic diversity of intracellular bacteria. Using a well-established epithelial cell line model, we have developed a platform called InToxSa (intracellular toxicity of S. aureus) to quantify intracellular cytotoxic S. aureus phenotypes. Studying a panel of 387 S. aureus bacteraemia isolates, and combined with comparative, statistical, and functional genomics, our platform identified mutations in S. aureus clinical isolates that reduced bacterial cytotoxicity and promoted intracellular persistence. In addition to numerous convergent mutations in the Agr quorum sensing system, our approach detected mutations in other loci that also impacted cytotoxicity and intracellular persistence. We discovered that clinical mutations in ausA, encoding the aureusimine non-ribosomal peptide synthetase, reduced S. aureus cytotoxicity, and increased intracellular persistence. InToxSa is a versatile, high-throughput cell-based phenomics platform and we showcase its utility by identifying clinically relevant S. aureus pathoadaptive mutations that promote intracellular residency.
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
Authors: Yanagihara Toyoshi , Hata Kentaro , Matsubara Keisuke , Kunimura Kazufumi , Suzuki Kunihiro , Tsubouchi Kazuya , Ikegame Satoshi , Baba Yoshihiro , Fukui Yoshinori , Okamoto Isamu
Published: June 2023

Anticancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia (PCP), which can cause severe respiratory complications and high mortality rates. Cytotoxic drugs and immune-checkpoint inhibitors (ICIs) can induce interstitial lung diseases (ILDs). Nonetheless, the differentiation of these diseases can be difficult, and the pathogenic mechanisms of such diseases are not yet fully understood. To better comprehend the immunophenotypes, we conducted an exploratory mass cytometry analysis of immune cell subsets in bronchoalveolar lavage fluid from patients with PCP, cytotoxic drug-induced ILD (DI-ILD), and ICI-associated ILD (ICI-ILD) using two panels containing 64 markers. In PCP, we observed an expansion of the CD16+ T cell population, with the highest CD16+ T proportion in a fatal case. In ICI-ILD, we found an increase in CD57+ CD8+ T cells expressing immune checkpoints (TIGIT+ LAG3+ TIM-3+ PD-1+), FCRL5+ B cells, and CCR2+ CCR5+ CD14+ monocytes. These findings uncover the diverse immunophenotypes and possible pathomechanisms of cancer treatment-related pneumonitis.
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Authors: Zhang Aixin , Jin Lei , Yao Shenqin , Matsuyama Makoto , van Velthoven Cindy TJ , Sullivan Heather Anne , Sun Na , Kellis Manolis , Tasic Bosiljka , Wickersham Ian , Chen Xiaoyin
Published: June 2023

Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the potential to map circuits at cellular resolution and a brain-wide scale, but existing Sindbis virus-based techniques can only map long-range projections using anterograde tracing approaches. Rabies virus can complement anterograde tracing approaches by enabling either retrograde labeling of projection neurons or monosynaptic tracing of direct inputs to genetically targeted postsynaptic neurons. However, barcoded rabies virus has so far been only used to map non-neuronal cellular interactions in vivo and synaptic connectivity of cultured neurons. Here we combine barcoded rabies virus with single-cell and in situ sequencing to perform retrograde labeling and transsynaptic labeling in the mouse brain. We sequenced 96 retrogradely labeled cells and 295 transsynaptically labeled cells using single-cell RNA-seq, and 4130 retrogradely labeled cells and 2914 transsynaptically labeled cells in situ. We found that the transcriptomic identities of rabies virus-infected cells can be robustly identified using both single-cell RNA-seq and in situ sequencing. By associating gene expression with connectivity inferred from barcode sequencing, we distinguished long-range projecting cortical cell types from multiple cortical areas and identified cell types with converging or diverging synaptic connectivity. Combining in situ sequencing with barcoded rabies virus complements existing sequencing-based neuroanatomical techniques and provides a potential path for mapping synaptic connectivity of neuronal types at scale.
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
Authors: Zhang Aixin , Jin Lei , Yao Shenqin , Matsuyama Makoto , van Velthoven Cindy , Sullivan Heather , Sun Na , Kellis Manolis , Tasic Bosiljka , Tasic Bosiljka , Wickersham Ian R. , Chen Xiaoyin
Published: June 2023

Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the potential to achieve circuit mapping at cellular resolution and a brain-wide scale, but existing Sindbis virus-based techniques can only map long-range projections using anterograde tracing approaches. Rabies virus can complement anterograde tracing approaches by enabling either retrograde labeling of projection neurons or monosynaptic tracing of direct inputs to genetically targeted postsynaptic neurons. However, barcoded rabies virus has so far been only used to map non-neuronal cellular interactions
in vivo
and synaptic connectivity of cultured neurons. Here we combine barcoded rabies virus with single-cell and
in situ
sequencing to perform retrograde labeling and transsynaptic labeling in the mouse brain. We sequenced 96 retrogradely labeled cells and 295 transsynaptically labeled cells using single-cell RNAseq, and 4,130 retrogradely labeled cells and 2,914 transsynaptically labeled cells
in situ
. We determined the transcriptomic identities of rabies virus-infected cells robustly using both single-cell RNA-seq and
in situ
sequencing. We then distinguished long-range projecting cortical cell types from multiple cortical areas and identified cell types with converging or diverging synaptic connectivity. Combining
in situ
sequencing with barcoded rabies virus thus complements existing sequencing-based neuroanatomical techniques and provides a potential path for mapping synaptic connectivity of neuronal types at scale.
Pharyngeal Mechanosensory Neurons Control Food Swallow in Drosophila melanogaster
Authors: Qin Jierui , Yang Tingting , Li Kexin , Liu Ting , Zhang Wei
Published: June 2023

As the first step of food ingestion, the swallow is under rigorous sensorimotor control. Nevertheless, the mechanisms underlying swallow control at a molecular and circuitry level remain largely unknown. Here, we find that mutation of the mechanotransduction channel genes
nompC, Tmc
, or
piezo
impairs the regular pumping rhythm of the cibarium during feeding of the fruit fly
Drosophila melanogaster
. A group of multi-dendritic mechanosensory neurons, which co-express the three channels, wrap the cibarium and are crucial for coordinating the filling and emptying of the cibarium. Inhibition of them causes difficulty in food emptying in the cibarium, while their activation leads to difficulty in cibarium filling. Synaptic and functional connections are detected between the pharyngeal mechanosensory neurons and the motor circuit that controls swallow. This study elucidates the role of mechanosensation in swallow, and provides insights for a better understanding of the neural basis of food swallow.
nompC
+
,
piezo
+
and
Tmc
+
neurons in the pharynx sense mechanical force during swallowingPharyngeal mechanoreceptor neurons regulate swallow rhythmDysfunction of pharyngeal mechanosensory neurons causes dysphagiaPharyngeal mechanosensory neurons connect with brain motor neurons to coordinate swallow pattern
Repensar la conexión con la naturaleza a través de las emociones
Authors: Castro Antonio J. , Otamendi-Urroz Irene , Quintas-Soriano Cristina , Suárez Alonso María Luisa , Vidal-Abarca María Rosario , Martín-López Berta
Published: June 2023

Entender la conexión y la desconexión del ser humano con la naturaleza es uno de los retos más importantes para la humanidad. La contribución científica de Fernando González Bernáldez, un naturalista por vocación y dedicación, se construyó sobre la necesidad de experimentar y entender la conservación a través de las relaciones afectivas que desarrollamos en y con la naturaleza. Sin embargo, son escasas las investigaciones desde la biología de la conservación que hayan dado continuidad a las respuestas emocionales asociadas a la naturaleza, en parte debido a la falta de consideración de las emociones como fuente de conocimiento objetivo. Esta dinámica parece estar cambiando y nuevas investigaciones comienzan a integrar las emociones en el estudio de las relaciones humano-naturaleza. La línea de investigación iniciada por Bernáldez es hoy clave para promover una transformación social que nos ayude a alcanzar la sostenibilidad en las relaciones humano-naturaleza y facilite la transición hacia un futuro más justo y sostenible.