bluuebunny/crossref_metadata_2025 huggingface dataset:
Resonance perturbation of (5026) Martes and 20052 WW113 asteroid pair
Authors: Rosaev Alexey
Published: December 2023

The orbital dynamics of a very young asteroid pair (5026) Martes and 2005 WW113 is studied. We detect strong resonant perturbations of the larger member of the pair (5026) Martes by the 3:11 mean motion resonance with the Earth. The unbounded secondary (2005 WW113) has orbited far from the resonance and is not perturbed. We provide a new estimation of the resonance structure and found that, under the planetary perturbations, a single resonance splits into a multiplet. The nominal position of the resonance is 2.37783 AU. However, the center of the corresponding chaotic zone is detected at 2.37754 AU. As a result, we noted a small but not negligible difference between the calculated and observed position of resonance. The multiplet structure of the 3:11 Earth resonance cannot explain this offset (the position of the main term of the multiplet is 2.377698 AU).
Study protocol for The Family Empowerment Program: A Randomized Waitlist-Controlled Trial to Evaluate the Effectiveness of Online Community Reinforcement and Family Training (CRAFT) on the Wellbeing of Family Members with a Relative Experiencing Substance Dependence and Mental Illness
Authors: Allan Julaine , Snowdon Nicole , Thapa Subash , Ahmed Kedir
Published: December 2023

Background Systematic reviews consistently show that family-focused interventions are effective at improving substance treatment engagement and outcomes across the lifespan. Yet, Australian substance use treatment services rarely incorporate family members and concerned significant others. Testing of family focussed interventions in the Australian context is required. Methods The trial is a randomized wait-list control trial assessing the effectiveness, feasibility and acceptability of online CRAFT with a parallel group. Participants will be randomised to receive either online CRAFT or to a wait-list control group who are provided with CRAFT related reading material during the waiting period. Outcomes will be assessed at baseline and then at 6- and 15-weeks post baseline. The primary outcome will be improved wellbeing of participating family members. The trial reporting will comply with SPIRIT guidelines. Discussion This study will focus on people living in rural areas. Substance treatment programs are limited in rural Australia. The provision of the Family Empowerment Program (CRAFT) online should make family focused substance treatment support accessible and attainable for the first time in rural areas. The outcomes of this trial could have meaningful implications for the future funding and support of family focused substance treatment services that are inclusive of people with mental health conditions. Trial registration ANZCTR, ACTRN12623000796684p, Registered 26 July 2023. Prospectively registered with protocol version 3.
Fibroblast-based FN1CFD contributes to parathyroid cancer identification using integrated analysis
Authors: Shen Rongfang , Yang Wenjing , Liu Xing , Wang Jiacheng , Feng Dalin , Zhao Li , Wang Yuting , Huang Jian , Shen Hong , Wang Qian , Zhao Teng , Wei Bojun
Published: December 2023

Parathyroid cancer (PC) is a highly aggressive cancer with high relapse and metastasis rate. However, there still lack effective preoperative and intraoperative ways to discriminate between PC and parathyroid adenoma (PA). The intrinsic biological alternations that lead to PC still unclear. Here, we performed integrated analysis on the transcriptomic data of parathyroid tumors. To identify pivotal genes associated with PC diagnosis, we integrated the immune infiltration analysis, gene differential analysis and ROC analysis, and discovered that fibroblast expressed gene FN1 and CFD (FC score) was of great importance. The cancer diagnostic value of FC score was also validated in pan-cancer data covering the TCGA bulk tumor and single cell data. Cell communication and cancer hallmark correlation analysis showed that FC score was strongly associated with EMT process, which was the key step for tumor invasion and metastasis. Our results suggest the tumor fibroblast phenotype defined by FC score contributed to PC identification.
Enhanced Heat Transfer Performance in a Solar Air Heater using discrete V-Rib Geometry with Gap
Authors: Dubey Manoj Kumar , Prakash Om
Published: December 2023

Solar air heater (SAH) have emerged as promising technology for harnessing solar energy in a sustainable and environmentally friendly manner. Numerous techniques for enhancing heat transfer methods have been investigated to improve thermal performance. This study investigated how discrete V rib coarseness effect the performance of SAH. The experiments were conducted under different operating conditions, including rib pitch-to-height ratios (p/e) of 8, 10, and 12, an angle of inclination of 60 degrees, width to height of duct (W/H) 8, gap width to depth 4, Centre distance between two successive ribs of 0.5, number of gaps on each side of 1 and Reynolds number of 4000 to 145000. Experimental data indicated that the SAH equipped with the discrete V-rib geometry and gap achieved higher heat transfer rates compared to traditional SAH designs without this feature. In this case, the Nusselt number (Nu), Thermo-hydraulic performance parameters (THPP) and friction factor (f) increased by 3.62, 3.22, and 2.85, respectively, compared to a flat plate. These values indicate the improvements achieved by the artificial rib coarseness in enhancing heat transfer compared to a flat surface. Furthermore, study demonstrated that the new discrete V-rib geometry with a gap outperformed to existing designs.
Modified S-P approach and Ganz surgical dislocation for the treatment of Pipkin I-type fractures: a long-term retrospective study
Authors: Zhang Hanwen , Deng wei , Wang Shengtao , Yin yong
Published: December 2023

Background
Posterior hip dislocation is the commonest type of hip dislocation. As it frequently combined fractures and may cause complications. Urgent hip reduction is mandatory to improve clinical outcomes and avoid irreversible complications. The purpose of the present study is to compare the clinical efficacy of the modified Smith-Peterson (mS-P) and Ganz surgical dislocation (GSD) in treating Pipkin I fractures.
Methods
A retrospective analysis of 23 patients diagnosed with Pipkin I femoral head fracture was conducted in Pidu District People's Hospital from June 2010 to May 2020. Regarding the treatment classification, 11 cases were treated with mS-P approach and 12 cases were treated with GSD approach. 1 case in each group lost the follow-up period in this study. The follow-up time of the rest 21 patients was 12–55 months, with an average of 37.7 months. Functional evaluation was done using the Thompson-Epstein Score, Modifed Harris Hip Score(MHHS), and Vail Hip Score (VHS) at final follow-up. The incision length, intraoperative time, intraoperative blood loss, intraoperative blood transfusion, length of stay in hospital, fracture healing time, and postoperative complications were also examined and compared between the two groups.
Results
According to the Thompson-Epstein function evaluation system, 6 patients (60%) had excellent results, 3 patients (30%) were rated as good, 1 patients (10%) as fair, and the excellent and good rate was 90% in mS-P group. And 3 patients (27.2%) had excellent results, 5 patients (45.5%) were rated as good, 2 patients (18.2%) as fair, 1 patient (9%) as poor and the rate of Excellent and Good results was 72.7% in GSD group. According to Harris hip score, 4 patients (40%) were rated as excellent, 2 patients (20%) as good; 4 patients (50%) as fair in mS-P group. Among cases of GSD group, 1 patient (9%) was rated as Excellent, 2 patients (18.2%) as good, 7 patients (63.6%) as fair and 1 patient (9%) as poor. According to VSH score, the average score of mS-P group was 82.3, and 74.4 in GSD group.
Conclusions
Both the mS-P and GSD approach can achieve a satisfactory result in surgical treatment of Pipkin I fractures. Open reduction and internal fixation(ORIF) of Pipkin I fractures using mS-P approach is more visual and less invasive than GSD approach, as well as less amount of bleeding. However, mS-P approach cannot provide satisfactory results with low occurrence of postoperative complications.
Development of a Self-management program in Empowering People with Parkinson`s disease: a qualitative study using a co-creation framework
Authors: Thomsen Trine Hørmann , Skovbølling Sara , Møller Morten , Brønden Maria , Grønlund Vibeke , Ilsfort Dorthe , Frederiksen Jakob , Biering-Sørensen Bo
Published: December 2023

Background
Empowerment of People with Parkinson`s disease (PwP), involves providing the individuals with the knowledge, resources, and support they need to take an active role in managing their consequences of PD and making informed decisions about their treatment options.
Aim
Using a co-creation framework, this study aimed to develop a self-management intervention in collaboration with PwP, relatives and cross-sectoral health care professionals to empower the affected individuals and mitigate the consequences of the disease.
Method
This explorative study used a co-creation framework and content analysis to develop a self-management program. A workshop and two focus group interviews with PwP (n = 6), caregivers (n = 3) and health care professionals/other stakeholders (n = 10) informed the development process.
Results
A 8-week self-management program was developed providing 5 teaching sessions with specific themes, 1 home visit by a PD-nurse for action planning, goal setting and motivational interviewing, development of a personal goal-setting tool (“PD GOAL”), mindfulness-sessions, and objective monitoring of motor symptoms via the Parkinson KinetiGraph Watch (PKG At Home™) during the program.
Conclusion
This study provides knowledge about developing an individualized, 8-week self-management program tailored PwP using a co-creation framework. Further, in-depth knowledge about everyday life and specific needs when living with PD, were identified.
Determinant of aggressive phenotype in metastatic hormone sensitive prostate cancer depends on an intrinsic, highly aggressive cell cluster: Integrated single- cell and whole transcriptomic analyses
Authors: Jee ByulA , Yu Jiwoong , Hwang Soohyun , Park Kyunghee , Han Kyung Yeon , Chung Jae Hoon , Song Wan , Sung Hyun Hwan , Jeon Hwang Gyun , Jeong Byong Chang , Seo Seong Il , Jeon Seong Soo , Lee Hyun Moo , Park Woong-Yang , Kang Minyong
Published: December 2023

Several studies have reported that prostate cancer has a relatively favorable prognosis; however, patients with locally advanced and metastatic disease have significantly low 10-year survival rates. Although the combination of androgen deprivation therapy with docetaxel or abiraterone acetate and prednisone has become the standard treatment for metastatic hormone-sensitive prostate cancer (mHSPC), and improved overall survival, a subset of patients is prone to developing castration-resistant prostate cancer. Furthermore, the underlying mechanisms governing treatment response in these patients remain poorly understood. The objective of this study was to identify aggressive cell types in patients with mHSPCs with poor clinical outcomes. A comprehensive analysis of samples from patients with mHSPC was conducted and validated using a cohort of 52 patients with mHSPC. Our results identified a distinct subtype characterized by proliferative activation associated with unfavorable clinical outcomes. A novel 14-gene signature serving as a predictive marker for survival outcomes was developed to facilitate prognosis and guide treatment decisions, particularly in patients with mHSPC. This study provides valuable insights into the identification of high-risk patients, novel biomarkers, and potential therapeutic targets for individuals with mHSPC. Furthermore, the results in this study can serve as a basis for future investigations aimed at refining prognostic strategies and developing targeted therapies for patients with mHSPC.
Influence of Nano Magnesium oxide fillers on Tensile and Impact strength of Banana fibre reinforced epoxy composites
Authors: Raghavendra Subramanya , Raveendra R S , GN Anil Kumar
Published: December 2023

A novel polymer composite has been developed by incorporating both alkali-treated and untreated banana fibres into an epoxy resin matrix. Using a hand layup technique, composite laminates were created by adding nano magnesium oxides as filler material with varying loadings (0.5%, 1%, and 1.5% wt) to the epoxy matrix. To further understand the characteristics of Nano MgO, X-ray diffraction synthesis was examined. An investigation was conducted to examine the impact of Nano magnesium oxide on the tensile and hardness characteristics. The 1.5% weight Mgo reinforced laminates exhibited a significant enhancement in characteristics when compared to the untreated banana fibre laminates. This phenomenon can be attributed to the enhanced dispersion and contact between the banana fibres and the epoxy in the composites, which facilitates a more effective transfer of stress at the interface.
Soil acidification drives the negative effects of nitrogen enrichment on soil microbial biomass at the global scale
Authors: Li Shucheng , Tang Shiming , Ju Xiaotang , Zhu Zhihao , Zhang Yujuan , Chen Hongyang , Jin Ke
Published: December 2023

Background and aims
Nitrogen (N) deposition is a global driver of change that affects microbial biomass and ecosystem processes. However, it remains unclear whether N enrichment impacts microbial biomass in soil across ecosystems.
Methods
In this study, we synthesized 1,385 paired observations from 125 studies worldwide to evaluate the effects of N addition on soil microbial biomass.
Results
We found that N enrichment substantially suppresses total microbial biomass, including bacterial, fungal, and arbuscular mycorrhizal fungi biomass. Importantly, we found strong negative effects on microbial biomass globally caused by N-enrichment-induced soil acidification. Moreover, N enrichment mainly shapes the acidification of soil through the increased concentration of ammonium and by changing exchangeable cations in soil, including magnesium, calcium, sodium, manganese, and aluminum ions.
Conclusions
Overall, our findings demonstrate that N-enrichment-induced soil acidification is a crucial factor to consider for preserving microbial communities and ecosystem function under future trends of increasing N enrichment.
Investigating The Metric Basis And Metric Dimension Of Graphene
Authors: Abbas Wasim , Chaudhry Faryal , Afzal Deeba , Farooq Umar
Published: December 2023

This article explores the metric dimension of graphene, atwo-dimensional carbon allotrope, examining how a minimal set of carbon atoms can uniquely determine the distances between all atoms in thegraphene lattice. We investigate the implications of metric dimension for characterizing graphene’s structural features and discuss its potentialapplications in electronics, energy storage, and nanotechnology. Thea rticle aims to contribute to the understanding of graphene’s unique properties and its practical use in various fields
Optimizing soft skills acquisition through simulation training: balancing realism and academic stress in a longitudinal cohort study
Authors: Bukeyeva Aliya , Hendrixson Vaiva , Kemelova Gulshat , Aimbetova Dinara , Drobchenko Yelena , Riklefs Viktor
Published: December 2023

Background Teaching methods evolve to meet the expanding needs of students, emphasizing not only academic and technical skills but also essential soft skills. Simulation, particularly in virtual reality, plays a pivotal role, fostering technical proficiency and crucial interpersonal skills for healthcare professionals. However, the stress faced by students in simulated scenarios is a critical concern. To enhance the learning experience, our study explores stress levels induced by diverse educational technologies and clinical cases, aiming to provide recommendations for refining simulation training programs for medical students.Methods In longitudinal cohort study at Karaganda Medical University, 57 fifth-year general medicine students underwent a two-week emergency conditions simulation course. Employing 5 simulation techniques, including standardized patients, high-fidelity simulation and various virtual patients, students navigated through 5 challenging clinical scenarios. Learning outcomes were assessed through ongoing tutor assessments and a final OSCE. Stress levels were measured using self-reporting survey and heart rate variability analysis using wearable devices during training sessions. In total, 265 training sessions were ultimately recorded and analyzed using MANOVA and MANCOVA statistical analyses.Results The analysis revealed that educational technologies closely mirroring real situations induce higher psychophysiological stress. Notably, the text-based and screen simulators exhibited lower physiological stress levels than more realistic technologies like standardized patients, high-fidelity and immersive virtual patient simulations. Final OSCE scores were also notably higher for less stressful technologies. The study underscores the nuanced relationship between educational technologies, clinical cases, and learning outcomes, emphasizing the importance of tailored approaches for effective simulation training allowing students to get all required soft skills.Conclusion Restructuring the simulation program involves employing diverse technologies for complex cases and a single technology for simpler ones. Assessing students' psychophysiological states via questionnaires and debriefing is vital for comprehending the impact of educational technologies on effective simulation training.
Targeted therapy of breast cancer using PLAC1 antibody-drug conjugate
Authors: Mahmoudian Jafar , Ghods Roya , Jeddi-Tehrani Mahmood , Ghaffari-Tabrizi-Wizsy Nassim , Nejadmoghaddam Mohammad Reza , Ghahremanzadeh Ramin , Ostad Seyed Nasser , Zarnani Amir-Hassan
Published: December 2023

Background
Placenta-specific 1 (PLAC1) is one of the oncoplacental genes ectopically expressed in a wide variety of cancers. Antibody drug conjugates (ADC) have the potential to substantially improve efficacy and reduce toxicity of treatment compared with cytotoxic small-molecule drugs and are recently being employed for treatment of cancers. Here, efficacy of a SN38-conjugated monoclonal anti-PLAC1 antibody was examined in breast cancer.
Methods and Results
Anti-human PLAC1 monoclonal antibodies were produced and characterized. SN38 was conjugated to an anti-PLAC1 antibody (clone: 2H12C12) and conjugation efficacy was evaluated by UV spectrophotometry. Post-conjugation reactivity was then tested using ELISA and flow cytometry. In vitro cytotoxicity profiling of 2H12C12-SN38 was examined on MDA-MB-231 breast cancer cells using a flourimetric assay. The effect of 2H12C12-SN38 on MDA-MB-231 tumor growth and angiogenesis ex vivo was tested by chorioallantoic membrane (CAM) assay followed by immunohistochemical analysis of tumor. Pharmacokinetics of 2H12C12-SN38 in mice was measured by successive venipuncture after ADC administration. Inhibitory effects of anti-PLAC1 ADC on tumor growth was assessed in nude mice xenograft model of human breast cancer. Anti-PLAC1 ADC exerted a substantial cytotoxicity on MDA-MB-231 cells starting from a concentration of about 33 nM. ADC also significantly decreased the growth of MDA-MB-231 tumors on CAM assay but did not show a significant effect on tumor angiogenesis. Pharmacokinetics of anti-PLAC1 ADC in mice showed an average half-life (t1/2) of about 80 hours. Treatment of nude mice with ADC resulted in a significant decrease in tumor size compared to isotype-matched antibody-SN38 conjugate, unconjugated anti-PLAC1 antibody or free SN38.
Conclusion
This is the first therapeutic application of anti-PLAC1 ADC in a xenograft model of human breast cancer. Our results reinforce on embryonic origin of cancers and shed light on the potential therapeutic benefits of targeting oncofetal antigens in human breast cancer.
Oleuropein protects against 5-Fluorouracil-Induced nephrotoxicity and hepatotoxicity in Rats
Authors: Banaei Shokofeh , Asghariazar Vahid , Mahdizadeh Faraz , Chinifroush-Asl Mir-Mehdi , Safarzadeh Elham
Published: December 2023

Purpose The renal and liver dysfunction is considered to be a life-threatening side effect of chemotherapy drugs such as 5-fluorouracil (5-FU). This study was designed to assess the effects of Oleuropein (OLE) against 5-FU-induced renal and liver toxicity. Methods Twenty-four adult Sprague-Dawley rats were randomly divided into 4 groups (N = 6) including the control, 5-FU (100 mg/kg), OLE (200 mg/kg), 5-FU + OLE. After treatment, blood sample were collected for the measurement of biochemical parameters, and the kidney and liver tissues were removed for the determination of inflammatory markers and histological changes. Results 5-FU significantly increased blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), liver enzyme levels, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) concentration. Also, histopathological findings of 5-FU showed acute tubular necrosis (ATN) in the renal tissues and coagulative necrosis in the hepatocytes. While the administration of OLE significantly decreased BUN-Cr, liver enzyme levels and inflammation and improved pathological changes. Conclusion Oleuropein exerted hepato-nephroprotective effects against 5-fluorouracil toxicity by the reduction of inflammatory factors.
Spectrophotometric Determination of Th(IV) in \ce{ThO2} dissolved liquid with Arsenazo III
Authors: Zhao Pengfei , Wu Jiuwei , Wang Yu , Li Yong , Guan Guoying
Published: December 2023

ThO2 can produce many useful elements after accelerator bombardment, such as Actinium-225, Radium-223, Molybdenum-99, Iodine-131, Strontium-90, etc. There are many methods for measuring heavy elements such as thorium, but most of them are complicated to operate. Spectrophotometry has the advantages of simple sample preparation and low operation difficulty, and can be used as a quantitative analysis method for thorium and other heavy elements. ThO2 ws dissolved with nitric acid and hydrogen fluoride, and the concentration of T(IV) in ThO2 solution was quantitatively analyzed with Arsenazo III as the chromogenic agent. Under the environment of 2 mol/L hydrochloric acid solution and 0.1 g/L Arsenazo III solution, the coordination ratio of Arsenazo III and Th(IV) is 5:2 under the experimental conditions determined by the finite logarithm method. The maximum absorption wavelength before and after color development is 534.0 nm and 663.2 nm, respectively, and the contrast is 129.2 nm. The method in 0.2∼5.0 mg/L in accordance with Lambert-Beer’s law, the standard curve equation A = 0.00176C+0.06641, R2 = 0.99981. The molar absorption coefficient of 1.64 × 104. Method detection limit is 0.31 μg/L, and quantitative limit is 0.97 μg/L. The method is stable within 4 h. The recovery is 97.33%∼104.03%, and the largest standard deviation is 0.32%. The method was compared with GB/T 12690.12-2003, the process was simplified and the results were basically consistent.
Alternative Approach to Copenhagen Interpretation
Authors: Kim Pil-Jae
Published: December 2023

In this study, a double-slit experiment was simulated with only classical-mechanics assumptions to demonstrate that the phenomena associated with this experiment can be explained by classical mechanics. The experiment was conducted with the particle nature intact, by performing observations that did not affect the particle motion while recording the particle position at each simulation step. Only one experimental particle was assumed per session to prevent external effects. Nevertheless, wave patterns, which have previously been thought to occur only quantum-mechanically, were observed on the inspection plate. This study focused on proving that classical mechanics can explain the double-slit wave pattern.
Cyber-Physical Secure Observer Synthesis under Model Mismatch and Unknown Input
Authors: Tahmasbi Mohammad , Farbod Alireza
Published: December 2023

This paper adresses a proportional-integral observer under cyber-physical system setting. This Proportional-Integral Observer (PIO) is designed to estimate the states of a linear system in presence of model mismatch, external disturbance, and unknown input. Accuracy and stability of a observer strongly depend on the accuracy of model and output measurements. In reality, these conditions are very rare, therefore it is required to develop a method for designing robust observers in presence of uncertainties, external disturbances and unknown input. A Lyapunov method and Linear Matrix Inequality (LMI) theory have been proposed to design the observer and to illustrate the stability of it. The stability of the proposed PI observer is proved and with numerical examples its efficiencies has been shown.
Cesarean scar pregnancy: a ten-year single center experience
Authors: Khanfir Fatma , Chaker Fatma , Fezzani Marwa , Akrout Besma , Chaabene Kais , Derbel Mohamed
Published: December 2023

Introduction:
Cesarean scar pregnancy (CSP) is a rare but potentially life-threatening form of ectopic pregnancy which incidence has been constantly raising during the last decades. The aim of this study was to describe the epidemiological characteristics of CSP in our population and to investigate the impact of different treatments on the maternal outcomes and prognosis.
Patients and methods:
This was a retrospective study including all patients diagnosed with CSP and who were admitted in our maternity between January 2010 and December 2020. Data were collected from the patients’ medical records. We compared outcomes (hospital stay duration, serum BHCG levels, complications, new pregnancy) in 2 groups: group 1 was treated with systemic injection of methotrexate (MTX) associated with dilatation curettage (DC) and group 2 was managed with uterine artery embolization (UAE) and DC.
Results:
The mean age was 33.5 years old. Most of patients (80%) reported history of 2 or more previous cesarean sections. The mean gestational age at diagnosis was 8 weeks. Patients presented mostly with isolated amenorrhea. The mean βHCG serum level at admission was 52352.4 milliunits/mL. The diagnosis was made on ultrasonographic examination in all cases. The Management of CSP in group 1 was associated with a significantly shorter resolution time of serum βHCG levels (p = 0.006). A shorter hospital stay duration was also reported in group 1 but with no statistical significance (p = 0.31). Complications were more observed in group 2 but with no statistical significance (p = 0.61).
Conclusion:
We concluded that UAE associated with an ultrasound-guided DC might be an interesting option for the management of CSP. An early and appropriate diagnostic with identification of cases at higher risk is necessary to reduce complications.
Comical Treatment of Queer Identities in The Merchant of Venice (Yugoslav Drama Theatre, 2004)
Authors: Obradović Ognjen
Published: December 2023

By analyzing the performance of The Merchant of Venice directed by Egon Savin, this paper explores the connection between the queer and the comic in contemporary Serbian theatre. The theoretical premise is that humor is a deeply paradoxical phenomenon: although it is usually perceived as a positive, vitalist, and subversive force, humor also functions as a repressive and conformist cultural mechanism that strengthens social norms. Our case study is a typical example of the stereotypical representation of queer identities which aims at inducing the comic effect. Antonio, the merchant of Venice, is portrayed as a typical inauthentic, superficial, and promiscuous gay man, while the character of Bassanio strengthens the most common representation of a bisexual as manipulative and mischievous. The most complex is the queer identity created by cross-gender casting in the interweaving of the physical body of the actor Dragan Mićanović and the semiotic body of the character of Portia. Considering the fact that there is no conceptual vindication for the cross-gender casting in the case of Portia, the incongruity of the man in a woman’s role primarily functions as a source of laughter. The excluding humor, based on the ridicule of queer identities, is partially amortized by the nuanced acting of Dragan Mićanović, which denaturalizes the Portia’s gender, emphasizing her queerness.
Percolation of the Past in the Middle Ages? Case-Study of the Necropolis Ravna–Slog near Knjaževac
Authors: Milosavljević Monika , Ilijić Bojana
Published: December 2023

The things surviving into the present from the previous epochs have under- gone the processes of selection and fragmentation.Therefore, the elements from the past that penetrate into another time are fragmented and represent a (material) memory of the previous practices, events, lifestyles, or an unknown that easily raises mystical ideas about the other worlds. Gavin Lucas describes this phenomenon of past penetrating into the present as percolation (lat. percolatio). The term is derived from chemistry, where it denotes filtration or drainage, i. e. the passage of fluid through a filter and separation of substances

The archaeological perspective is capable to deal with the coexistence of sets of material culture from various times in thepresent. On the other hand, the polychrony of archaeological assemblages has often been purified and separated through scientific practices – as if the present is not always filled with the past. The interpretation of the mutual relations among the past times andtheir usage/ meaning in the new contexts is not susceptible to simple solutions. It is hard to explain why a certain event or an objectdisappears from the memory and usage, while others endure into the present or occur again.

The paper analyses the Early Medieval funerary contexts from the necropolis Ravna–Slog in which the artefacts originating from the Roman or prehistoric periods are registered along with the Medieval ones. The similar phenomenon is registered in the case ofthe Avar-Period graves. The mixed contexts from Ravna are interpreted as the consequence of the need to construct the link to the past, with the aim to legitimize the presence in the new territory.
Johann Albrecht von Reiswitz: From “Uneasy Scholar” to Ahnenerbe Collaborator. Notes about a Book
Authors: Bandović Aleksandar
Published: December 2023

The paper critically examines some of the conclusions of the historian Andreas Roth concerning the activities of Johann Albrecht von Reiswitz in the Kingdom of Yugoslavia and the occupied Serbia. It is stressed that biographies or studies aiming at biographical representation require a clear theoretical-methodological framework, situating the actors into relevant social structures. Instead of picturesque details, abounding in traditional biographies, it is essential to analyse the protagonist through various social orderings in which he acted and to which he adapted. Following this principle, the inconsistencies and contradictions apparent in Roth’s book are pointed out. Contrary to his opinion, in this paper it is argued that the work of Reiswitz cannot be ideologically and practically separated from the activities of the Military-Administrative Headquarters, or the organization Ahnenerbe. None of Reiswitz’s actions took place outside of the general ideology of Nazism, where personal professional advancement was linked to the cumulative radicalisation of the regime. Here it is demonstrated that he not only was ambivalent towards the crimes taking place around him, but was also actively involved, through his collaboration with SS Ahnenerbe, to justify the newly established order in the occupied Serbia. Roth leans upon the authority of some private testimonies, but instead of de-mystifying them, he contradicts his own previous conclusions.
KARALAMA FİİLİNİN KİŞİLİK HAKKININ İHLALİ KAPSAMINDA DEĞERLENDİRİLMESİ
Authors: ŞAHANKAYA Sarp
Published: December 2023

Karalama fiili en kısa şekilde gerçeğe aykırı bir beyan ile başkasının itibarının zedelenmesi olarak ifade edilebilir. Günümüzde basının ve özellikle sosyal medyanın gelişimi ile birlikte bilgi ve/veya içerik, çok kısa sürede çok fazla kişiye ulaşılabilmektedir. Bu kolaylık gerçeğe aykırı bilgi verilerek bir kişinin kişilik hakkının ihlal edilmesi ihtimalini ve bunun uygulanmasını da artırmaktadır. Uygulamadaki yaygınlığı ve önemi nedeniyle karalama fiilinden yola çıkılarak manevi kişisel değerler ve kişilik hakkının korunması - yüksek mahkeme kararları ve yabancı doktrin de nazara alınarak - inceleme konusu yapılmıştır. Manevi kişisel değerlerin net şekilde tespit edilmesi ve sınırlarının mutlak çizgilerle çizilmesi güçlük arz etmektedir. Bununla birlikte çalışmada özellikle itibar/şeref ve haysiyet değerleri üzerinde durulmuş, bunlar somutlaştırılmaya çalışılmıştır. Türk Medeni Kanunu’nda yer verilen kişilik hakkını koruyan davalar, İsviçre hukuku da göz önünde tutularak incelenmiş ve güncel eğilimler ortaya konulmuştur. Kişilik hakkını koruyan davalar ile birlikte gündeme gelen “yayımlanma” imkânı, itibarın iade edilmesi bakımından önem arz etmektedir ve çalışmada detaylı şekilde incelenmiştir.
Formation of yield and seed quality of linseed varieties (Linum humile Mill.) in the conditions of the Western Forest Steppe of Ukraine
Authors: Lialchuk P. P. , Bakhmat M.I. , Makarchuk B. M.
Published: December 2023

Purpose. To determine the peculiarities of yield and seed quality formation of varieties of linseed (Linum humile Mill.) in the conditions of the Western Forest Steppe of Ukraine.
Methods. The research was conducted in 2020–2021 at the experimental field of the Khmelnytskyi branch of the Ukrainian Institute for Plant Varieties Examination (Trebukhivtsi village, Letychivskyi district, Khmelnytskyi region). Sowing was carried out in the second decade of April, the sowing rate was 8.0 million seeds per hectare. Subjects of the research were oil flax varieties ‘Orfei’, ‘Svitlozir’ and ‘Vodohrai’. The experimental design, evaluation of material, phenological observations and biometric measurements of plants, harvesting were carried out in accordance with the “Methodology for the qualification examination of plant varieties of the technical and fodder group for suitability for distribution in Ukraine”. The quality indicators of linseed were determined according to the “Methodology of qualification examination of plant varieties for suitability for distribution in Ukraine”.
Results. The optimal conditions of the Western Forest Steppe of Ukraine contributed to the timely onset of the phenological phases of growth and development, as well as to the insignificant variation in the duration of the vegetation period (from 96 to 99 days) of the flax plants. Productivity was assessed using indicators such as the number of pods and the weight of seeds per plant. Under the condition of sowing on 25 April and the sowing rate of 8.0 million seeds per hectare, the highest yield was characterised by the variety “Svitlozir” (1.45 t/ha), the lo­west – ‘Orfei’ (0.8 t/ha). The varieties ‘Orfei’, ‘Svitlozir’ and ‘Vodohrai’ were evaluated by biochemical indicators and the content of crude protein, oil and fatty acids (palmitic, stearic, oleic, linoleic, linolenic, gondoic, eicosapentaenoic and erucic) was determined. Thus, ‘Orfei’ was characterised by the highest amount of protein in the seeds – 24.15%; ‘Svitlozir’ had an indicator of 22.74%; ‘Vodohrai’ – 22.26%. A high percentage of oil in the total dry matter was found in ‘Vodohrai’ – 45.6%, which is 2.19% more than in ‘Orfei’. The content of linolenic acid varied from 45.703 (‘Orfei’) to 48.261% (‘Svitlozir’) and erucic acid was not detected in any of the varieties during the study.
Conclusions. The varieties ‘Orfei’, ‘Svitlozir’ and ‘Vodohrai’ were characterised by more than 35% oil content in seeds, which meets the requirements of State Standard 7577:2014 and ensures the quality of marketable oil flax products.
Man as the central theme of the philosophical and anthropological manuscript of Metropolitan Platon (Levshin)
Authors:   Belgorod State National Research University, Lipich Tamara I. , Nifontova Olga I. ,   Belgorod State National Research University
Published: December 2023

The article is devoted to the study of the first deciphered manuscript “Dogmatic Theology” by Metropolitan Platon (Levshin), a representative of the Russian theological academical philosophy of the first half of the 19th century. The purpose of this article is to undertake for the first time a philosophical and anthropological analysis of the main content of the manuscript. In the course of the research, the main thematic sections of this work are identified: the doctrine of the world (cosmology), the doctrine of angels (angelology) and the doctrine of man (anthropology), within which Christological and anthropological problems are considered. All the topics are connected by one main theme — the theme of man and his fate, which underlies all the arguments of Metropolitan Platon and leads to a conclusion about the anthropological orientation of the studied manuscript of theological academical philosophy of the first half of the 19th century. In the manuscript of Metropolitan Platon (Levshin) “Dogmatic theology” the doctrine of man is revealed quite fully, deeply and consistently. At the same time, some contradictory statements have been found on the issues of the original existence of moral evil in man and immortality and painlessness originally inherent in man. Presumably, these contradictions are connected with some complexity of the presentation of the non-worldly Divine teaching in earthly terms and formulations for theological academical authors of the first half of the 19th century.
The conception of Living Tradition in the context of the life and work of Jaroslav Pelikan
Authors:   St Tikhon’s Orthodox University, Pronina Anna S.
Published: December 2023

The article considers the issue of the formation of the idea of a Living Tradition in the scientific and social activities of the American scientist Jaroslav Pelikan (1923–2006). In the life and intellectual path of a scientist, three stages — early, middle and late ones — are conditionally identified. The article shows that the concept of Living Tradition is the result of the development of two sides of Pelican’s life and that the study of the Christian tradition can lead to a change in confessional affiliation. Particular attention is paid to the middle and late periods of his intellectual and spiritual searches, at the stage of which the scientist discovers the heritage of the Ancient Church. The article also highlights the Pelikan’s theological features of the conception of the Living Tradition. Through the idea of a Living Tradition, the scientist reconciles the continuity of the tradition of the Church and the changes within this continuum. The article shows that the conception of Living Tradition is closely connected with the idea of catholicity and continuity of the Church. The author claims that, firstly, the Pelikan, in the idea of Tradition, adopted the language of representatives of the Catholic school of Tubingen and the Orthodox Neo-Patristic school. At the same time, the theological thought of J. Pelikan continues to move within the strict framework of the set research goal — historical research and justification of continuity and changes in the Church. It is also shown that J. Pelikan’s views on the conception of Living Tradition are largely dictated by his correspondence polemic with his predecessor A. von Harnack. In addition, the article concludes that the Pelikan in his understanding of Tradition is not so sensitive to the Divine within Tradition, understood as the action of the Holy Spirit in the Church. At the end of the article, it is demonstrated that at the late stage of his work, Pelikan fails to fully solve the problem of Tradition. This research can be useful for everyone who is interested in the life and work of modern theologians and Christian historians.
Institute for the Study of Islamic Thought and Civilizations as an actor in the process of Islamization in modern Indonesia
Authors:   Voronezh State University, Kyrchanoff Maksym W.
Published: December 2023

The presented article analyzes the features of development and the main vectors of transformation of conservative Islam in modern Indonesia in contexts of the activities of the organization known as the Institute for the Study of Islamic Thought and Civilizations (INSISTS). INSISTS is supposed to be the intellectual center of contemporary Islamic traditionalism in Indonesia. The article analyzes the problems of the intellectual agenda of conservatives, including the ideas of the Islamization of science, the rejection of liberal Islam and the criticism of feminism. The article considers the main directions of Muslim conservatives activity as a reaction to the modernization of the Ummah and the temporary success of liberal Islam, although its influence on Muslims was extremely limited. It is believed that INSISTS appeared as an attempt to institutionalize and legitimize conservative and traditionalist trends in modern Indonesian Islam in the form of their expansion into the space of scientific knowledge and political criticism. It is shown that INSISTS, as a formally conservative institution, actually uses liberal discourse, trying to actualize the contemporary problems related to gender and feminism in the political agenda of traditionalists. Therefore, it is assumed that the conservative trends in the modern history of the Indonesian Ummah actualize the significant adaptive potential of the traditionalists.
Nakshubandi rabita on the scales of Sharia
Authors:   Dagestan Islamic University named after Sheikh Muhammad-Arif, Atsaev Abdulla S.
Published: December 2023

The article is devoted to the theological consideration of one of the forms of manifestation of sincerity in Sufi practice, an integral part of the ritual practice of the tarikat — rabita. The origins of the term rabita, its semantics, and the attitude to this phenomenon from the standpoint of Sharia are investigated. The conclusions are substantiated by an appeal to the sacred texts of the Holy Quran and the Sunnah, as well as to the authoritative opinion of theologians of the past. The author, revealing the originality of tasawwuf not only as a “renunciation of the worldly” for the purpose of moral improvement, but also as a way of sincere rapprochement with the Creator in the act of cognition (ma’rif), explores the essence of rabita in the understanding of the Sufis, questions of the permissibility of spiritual guidance, Sharia decisions regarding rabita as a form of sincerity (ihsan). A categorical typology of rabita in tasawwuf is presented. Since rabita in the form referred to in the writings of Sufi scholars is not a ritual of worship, but is a type of concentration of thoughts and feelings inherent in the natural nature of a person, a Sharia decision “permissible” is made in relation to it, which can turn into “desirable” or even “mandatory”, based on its constituent elements and the goals that are achieved through rabita.
Synchronous Bilateral Brachial Blood Pressure Measurements Increased
Orthostatic Hypotension Detection in the Elderly
Authors: Zhang Jianying , Gao Xia , Ma Benxu , Liu Lili , Gao Huanmin
Published: December 2023

Background:

Orthostatic hypotension (OH) is a common clinical sign, but its detection rate is low, and it is difficult to repeat because there is no standardized screening method
available.

Aim:

This study aimed to establish a method for detecting blood pressure and assess whether it
could increase the OH detection rate in the elderly.

Methods:

From May to October, 2022, 178 patients with symptomatic OH and 286 subjects with
asymptomatic OH were selected. BP from the bilateral brachial artery was measured using two
electronic sphygmomanometers on both arms at the same time, in the order of supine, sitting,
and standing at 0-3 min. OH should meet 20/10 mmHg, standing BP minus sitting BP. The OH
detection rates were calculated and compared. The symptomatic OH group was more often older,
slimmer, had lower ADL scores, and contained fewer smokers (all P< 0.05).

Results:

The detection rate of the symptomatic OH group using the modified method was
59.55%, which was higher than that of the routine method (34.83% vs. 59.55%, P<0.05). The detection rate using the modified method in the OH group with asymptomatic OH was 20.63%,
which was higher than that of the routine method (20.63% vs. 5.59%, P< 0.01).

Conclusion:

Synchronous measurement of bilateral brachial artery BP in supine, sitting, and
standing positions increased the detection rate of OH in the elderly.
Role of Complement-dependent Cytotoxicity Crossmatch and HLA Typing
in Solid Organ Transplant
Authors: Tiwari Arpit , Mukherjee Sayali
Published: December 2023

Background:

Solid organ transplantation is a life-saving medical operation that has
progressed greatly because of developments in diagnostic tools and histocompatibility tests.
Crossmatching for complement-dependent cytotoxicity (CDC) and human leukocyte antigen
(HLA) typing are two important methods for checking graft compatibility and reducing the risk
of graft rejection. HLA typing and CDC crossmatching are critical in kidney, heart, lung, liver,
pancreas, intestine, and multi-organ transplantation.

Methods:

A systematic literature search was conducted on the internet, using PubMed, Scopus,
and Google Scholar databases, to identify peer-reviewed publications about solid organ
transplants, HLA typing, and CDC crossmatching

Conclusion:

Recent advances in HLA typing have allowed for high-resolution evaluation,
epitope matching, and personalized therapy methods. Genomic profiling, next-generation
sequencing, and artificial intelligence have improved HLA typing precision, resulting in better
patient outcomes. Artificial intelligence (AI) driven virtual crossmatching and predictive
algorithms have eliminated the requirement for physical crossmatching in the context of CDC
crossmatching, boosting organ allocation and transplant efficiency. This review elaborates on the
importance of HLA typing and CDC crossmatching in solid organ transplantation.
The Comparison Of Chest X-Ray Changes Between Post-Covid-19-Infection Patients With Mild-Moderate Severity And Severe-Critical Severity At Ugm Academic Hospital
Authors: Nadira Adristi Amaradinka  , Siswanto  , Henda Ageng Rasena  , Roihan Mohamad Iqbal  , Rahmaningsih Mara Sabirin  , Rakhmat Ari Wibowo  , Dwi Damar Andriyani
Published: December 2023

Introduction: Post-COVID-19 syndrome can be seen from the radiological findings on the chest X-ray (CXR). However, limited studies compared CXR changes in post-COVID-19 patients based on their severity. 
Methods: Thirty-three post-hospitalized COVID-19 patients who came to the Long COVID Clinic at UGM Academic Hospital were divided into mild-moderate and severe-critical groups. The CXR were taken during hospital admission, in the 4th week, and in the 8th week. CXR images were assessed with the Brixia Score method.
Results: The Brixia score in the mild-moderate group (n = 17) and severe-critical (n = 16) group showed a trend of change, which increased in the 4th week and decreased in the 8th week. However, there were no significant changes between the two groups during hospital admission, in the 4th week, and in the 8th week. The Brixia score during hospital admission and in the 8th-week follow-up in the mild-moderate group was significantly lower than that of the severe-critical group. Clinically, the mean Brixia score in the mild-moderate group ranges from mild pneumonia, while the severe-critical group ranges from moderate pneumonia.
Conclusion: There is no significant resolution of the CXR until the 8th-week follow-up in post-COVID-19 infection patients with mild-moderate and severe-critical severity. However, the CXR during hospital admission and the 8th week is better in post-COVID-19 infection patients with mild-moderate severity.
Keywords: chest X-ray, COVID-19, infectious disease, post-COVID-19 syndrome, severity,