bluuebunny/crossref_metadata_2025 huggingface dataset:
Substance P is overexpressed in cervical squamous cell carcinoma and promoted proliferation and invasion of cervical cancer cells in vitro
Authors: Wang Ying , Yuan Shifa , Ma Jing , Liu Hong , Huang Lizhen , Zhang Fengzhen
Published: July 2023

This study aimed to investigate the expression and function of substance P in cervical squamous cell carcinoma. Cancer tissues and adjacent tissues of 20 patients with cervical squamous cell carcinoma in our hospital were collected. The expression of substance P was detected by immunohistochemistry and Western blot analysis. Cervical squamous cell carcinoma line SiHa was treated with different concentrations of substance P. The proliferation of SiHa cells was detected by EdU assay, and the invasion ability of SiHa cells was detected by transwell assay. The phosphorylation of ERK1/2 and the expression of MMP9 were detected by Western blot analysis. The results showed that substance P was expressed in the cytoplasm and some cell membranes of cervical squamous cell carcinoma cells. The expression of substance P in cervical cancer tissues was significantly higher than that in the adjacent tissues. Compared with the control group, substance P significantly promoted the proliferation and invasion of SiHa cells in a concentration dependent manner and activated the phosphorylation of ERK1/2 and upregulated the expression of MMP9 in SiHa cells. In conclusion, substance P is highly expressed in cervical squamous cell carcinoma and can promote cervical cancer cell proliferation and invasion. The mechanism is related to the activation of ERK1/2 pathway to upregulate MMP9.
Odontogenic Submandibular and Descending Necrotising Fasciitis or Myositis – A Case Report on a Clinical Dilemma
Authors: Kaur Paramjot
Published: July 2023

The Rationale:

Odontogenic space infection has the potential to spread uncontrollably into adjoining fascial spaces. Prompt diagnosis and management are mandatory to prevent gross morbidity and death.

Patient Concerns:

We present a case report of odontogenic origin-submandibular necrotising fasciitis and myositis in a lactating female.

Diagnosis:

Computed tomography scan revealed an ill-defined fluid collection with air foci within it in the left submandibular region with evidence of extension along the left sternocleidomastoid and along the strap muscles of the neck. Histopathology of the necrotic tissue confirmed necrotising fasciitis.

Treatment:

Extensive surgical debridement and tooth extraction of left mandibular second molar under antibiotic cover.

Outcomes:

Uneventful post-surgical wound healing and general medical condition of the mother and child were satisfactory at 13th-month follow-up.

Take-Away Lessons:

Prompt diagnosis and management of odontogenic fascial space infection in a lactating mother to prevent the spread of infection in both lactating mother and the child.
Comparison of Transconjunctival versus Subtarsal Approach in Orbital Reconstruction with Respect to Post-Operative Complications and Aesthetic Outcome - A Systematic Review
Authors: Bagade Sachin Prakash , Joshi Sanjay S. , Khathuria Pranchil Vinod , Mhatre Bhupendra V.
Published: July 2023

Background:

Limited evidence exists regarding the optimal surgical approach for orbital floor reconstruction, resulting in uncertainty regarding the choice of approach with the best aesthetic outcomes and lowest post-operative complications.

Objectives:

This systematic review aimed to compare the transconjunctival and subtarsal approaches (STA) in orbital reconstruction in terms of post-operative complications and aesthetic outcomes.

Data Sources:

The systematic review was conducted following PRISMA guidelines. PubMed, Google Scholar and Cochrane databases were searched from January 1, 2000 and December 31, 2021.

Study Eligibility Criteria:

Eligible studies included clinical studies comparing the transconjunctival and STA approaches in orbital reconstruction. The outcome variables assessed were aesthetic scar, hyperaesthesia, entropion, ectropion, enophthalmos, epiphora and other complications. A total of 346 articles were initially identified, and after evaluation using Mendeley software, 292 articles were reviewed. Finally, five articles that met the inclusion criteria were included in this systematic review.

Study Appraisal and Results:

The transconjunctival approach demonstrated superior aesthetic outcomes compared to the STA approach. However, the STA approach had a lower incidence of post-operative complications, including hyperaesthesia, entropion, ectropion, enophthalmos and epiphora.

Limitations:

The main limitation of this systematic review is the limited availability of literature directly comparing these two approaches, which precluded the inclusion of randomised controlled trials. Furthermore, the search strategy was restricted to specific databases, namely PubMed/Medline, Google Scholar and the Cochrane Collaboration Library.
Klotho Inhibits the Activation of NLRP3 Inflammasome to Alleviate Lipopolysaccharide-Induced Inflammatory Injury in A549 Cells and Restore Mitochondrial Function through SIRT1/Nrf2 Signaling Pathway
Authors: Zeng Yanjun , Xu Gang , Feng Congrui , Cai Danyan , Wu Sizhi , Liu Yuanling , Chen Yuluo , Ma* Wei
Published: July 2023

Acute lung injury is a severe clinical condition constituting a major cause of mortality in intensive care units. This study aimed to investigate the role of klotho in alleviating lipopolysaccharide (LPS)-induced acute lung injury. LPS-induced acute lung injury was used to simulate the acute lung injury caused by severe pneumonia in vitro. The viability and apoptosis of A549 cells were detected by cell counting kit-8 assay and flow cytometry. The inflammatory response, oxidative stress, and mitochondrial function in A549 cells were analyzed by commercial assay kits and 5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethyl-benzimidazolyl carbocyanine iodide (JC-1) staining. The expression of apoptosis-related proteins, Sirtuin 1 (SIRT1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway-related proteins, and NOD-like receptor family pyrin domain containing 3 (NLRP3) expression in A549 cells was detected by western blot. The mtDNA synthase level in A549 cells was analyzed by reverse transcription-quantitative polymerase chain reaction. The results showed that, klotho had no cytotoxic effect on A549 cells. The viability and mitochondrial function were inhibited and apoptosis, inflammatory response, and oxidative stress were aggravated in LPS-induced A549 cells, which were all reversed by klotho. Klotho activated the SIRT1/Nrf2 signaling pathway to inhibit the LPS-induced NLRP3 inflammasome activation in A549 cells. However, EX527, a SIRT1 inhibitor, attenuated the klotho effect to suppress viability and mitochondrial function and promoted apoptosis, inflammatory response, and oxidative stress of A549 cells. In conclusion, klotho inhibited the activation of NLRP3 inflammasome to alleviate LPS-induced inflammatory injury of A549 cells and restore mitochondrial function through activating the SIRT1/Nrf2 signaling pathway.
Toric intraocular lenses versus paired opposite corneal incisions in correction of low-grade astigmatism after phacoemulsification
Authors: Ebeid Weam M. , Abozeid NourEldin H.
Published: July 2023

Purpose

To compare toric intraocular lens (IOL) implantation versus monofocal (Eyhance) IOL with paired corneal incisions for correction of low-grade astigmatism after phacoemulsification.

Patients and methods

A retrospective comparative study included 30 patients with low-grade astigmatism (−0.75 to −1.50 D) who underwent phacoemulsification: group 1 underwent toric IOL implantation (TECNIS toric) and group 2 underwent enhanced monofocal IOL (TECNIS Eyhance) with paired corneal incision along steep corneal meridian. Best-corrected visual acuity, astigmatism power, and axis were assessed preoperatively and 3 months postoperatively. Vector analysis of astigmatism was done using the Alpins method.

Results

The mean postoperative residual astigmatism was significantly lower in group 1 versus group 2 (−0.357±0.128 and −0.538±0.225 D, respectively; P=0.015). A significantly higher decrease in astigmatism was noted in group 1 (−0.93±0.18 and −0.38±0.69 D, respectively; P=0.006), with no significant difference in postoperative visual acuity. Paired comparison revealed significant decrease in astigmatism (P<0.0001 in group 1 and 0.04 in group 2) and improvement in uncorrected visual acuity (P<0.0001 for both groups). A significantly higher percentage of success was noted in group 1 (P=0.017), with a higher difference vector in group 2 (P=0.008).

Conclusion

Our results suggest that both toric IOL and paired corneal incision are efficient methods for postoperative astigmatism correction and achieving postoperative spectacle independence in patients with low-grade astigmatism. Toric IOL is superior in reducing postoperative astigmatism, reflecting more consistent results. The recommendation of IOL type and astigmatism correction should be tailored according to the patient's requirements, especially with the expanded need for good intermediate vision for everyday tasks that may benefit from enhanced IOLs.
Spectacle measurements versus contact lens measurements of the angle of deviation in myopic patients with strabismus
Authors: Hassanein Dina H. , Awadein Ahmed , Youssef Aya , Shokier Gihan M.
Published: July 2023

Purpose

To compare the measurements of the angle of deviation through spectacles versus contact lenses and with the theoretically calculated angle.

Patients and methods

A total of 20 patients with comitant strabismus, more than 20 PD with spectacles, associated with bilateral myopia (spherical equivalent >1 D in both eyes) were included. Angle of deviation was measured using prism and cover test with spectacles and with contact lenses fitted according to the cycloplegic refraction and refined by subjective refraction. Agreements between the measurements obtained with contact lenses and those obtained with spectacles as well as the theoretically calculated angle were analyzed.

Results

The mean age was 15.6±10.9 years. Average spherical equivalent was −9.1±4.2 D. Measurements obtained with contact lenses were significantly lower than those with spectacles (P<0.001) with coefficient of variation of 27.7%, indicating poor agreement of both measurements. Limits of agreement in Bland–Altman plots were more than 9 PD (d ± 2 s, −8.8 to 6 PD). The agreement was lower with larger angles. Measurements obtained with contact lenses were significantly lower than theoretical angles (P=0.002) but coefficient of variation between both measurements was 8.8%, indicating good agreement of measurements. There was little systematic or proportionate bias between the contact lens measurements and the theoretical angle.

Conclusions

Contact lens measurements were significantly lower than spectacle measurements in myopic patients. The contact lens measurements were in good agreement with the theoretically calculated angle. This overestimation of the angle with spectacles might be responsible for overcorrection of myopic patients with exotropia after surgery.
Post-COVID-19 mucormycosis: A prospective, observational study in patients undergoing surgical treatment
Authors: Wadhawan Sonia , Kerai Sukhyanti , Husain Farah , Labani Preeti , Agarwal Munisha , Saxena Kirti N.
Published: July 2023

Background and Aims:

Post the second wave of COVID-19 in India, our institute became a dedicated center for managing COVID-19-associated mucormycosis (CAM), but there was a paucity of data regarding perioperative considerations in these patients. The objectives of present study was to describe the preoperative clinical profile, the perioperative complications and outcome of CAM patients undergoing urgent surgical debridement.

Material and Methods:

This prospective observational study was conducted on CAM patients presenting for surgical debridement from July to September 2021. During preoperative visits, evaluation of extent of disease, any side effects of ongoing medical management and post-COVID-19 systemic sequalae were done. The details of anaesthetic management of these patients including airway management, intraoperative haemodynamic complications and need for perioperative blood transfusion were noted.

Results:

One hundred twenty patients underwent surgical debridement; functional endoscopic sinus surgery (FESS) was carried out in 63% of patients, FESS with orbital exenteration in 17.5%, and maxillectomy in 12.5%. Diabetes mellitus was found in 70.8% and post-COVID new onset hyperglycemia in 29.1% of patients. Moderate-to-severe decline in post-COVID functional status (PCFS) scale was observed in 73.2% of patients, but with optimization, only 5.8% required ICU management. The concern during airway management was primarily difficulty in mask ventilation (17.5%). Intraoperatively, hemodynamic adverse events responded to conventional treatment for hypotension, judicious use of fluids and blood transfusion. Perioperatively, 10.8% of patients required blood transfusion and 4.2% of patients did not survive. Non-surviving patients were older, with a more aggressive involvement of CAM, and had comorbidities and a greater decline in functional capacity.

Conclusion:

A majority of patients reported a moderate-to-severe decline in PCFS that required a preoperative multisystem optimization and a tailored anesthetic approach for a successful perioperative outcome.
Comparison of analgesic efficacy of ultrasound-guided quadratus lumborum block versus erector spinae plane block in children undergoing elective open pyeloplasty – A randomized, double-blinded, controlled study
Authors: Ralte Isaac Lalfakzuala , Bhoi Debesh , Talawar Praveen , Prasad Ganga , Subramaniam Rajeshwari , Goel Prabudh
Published: July 2023

Background and Aims:

Comparison of analgesic efficacy of ultrasound-guided transmuscular quadratus lumborum block (QL-3) and erector spinae block (ESP) in children undergoing open pyeloplasty was done in this study.

Material and Methods:

This was a randomized, double-blinded, controlled study conducted in a tertiary care center, operating rooms, post-anesthesia care unit (PACU), and paediatric surgical ward. Sixty children of age 1–6 years, with American Society of Anesthesiologists (ASA) status I or II, undergoing elective open pyeloplasty were included in the study. Patients were randomized into two groups: group I (QL block-3) and group II (ESP). Both blocks were performed under USG guidance using 0.5 ml/kg of 0.25% ropivacaine after induction of general anesthesia. Postoperative Modified Objective Pain Score (MOPS), perioperative hemodynamic parameters, perioperative time for first rescue analgesia, total rescue analgesia, and incidence of complications were recorded. Statistical tests were applied as follows: (i) quantitative variables were compared using independent t-test/Mann–Whitney test (when the data sets were not normally distributed) between the two groups, and repeated measure analysis of variance (ANOVA)/Friedman test was used for comparison between different time intervals within the same group and (ii) qualitative variables were correlated using the Chi-square test/Fisher’s exact test. A P value of <0.05 was considered statistically significant.

Results:

Pain was assessed using MOPS in the postoperative period at 0, 30 min, 1, 2, 4, 6, 12, and 24 h. Overall, the pain scores were low and showed a decreasing trend toward baseline as time progressed. Group I showed lower score, but was statistically significant only at the sixth hour. Highest mean score was 2.4 ± 2.01 in group I and 2.67 ± 2.32 in group II. Perioperative hemodynamic parameters were comparable. Total rescue analgesia during the perioperative period was not statistically significant (intraoperative P = 0.075 and postoperative P = 0.928). Also, 63.33% patients in group I and 63% patients in group II required rescue analgesia in the postoperative period and were comparable. Mean ± standard deviation (SD) for first rescue analgesia time was 6.32 ± 12.57 in group I and 16.67 ± 31.25 in group II, but not significant. The distribution in group II was skewed, hence the larger value for group II, but when compared to group I, this was statistically not significant.

Conclusion:

Both ultrasound-guided ESP block and QL block using 0.25% ropivacaine 0.5 ml/kg provided adequate analgesia during the first 24 h post-surgery in children undergoing open pyeloplasty. The fentanyl requirement during the first 24-h postoperative period was also decreased.
Evaluation of perfusion index as a predictor of successful caudal block in pediatric patients: A prospective randomized study
Authors: Vashishth Sumedha , Nandal Nancy , Kaur Kiranpreet , Kadian Yogender S. , Johar Sanjay , Kaur Svareen , Bhardwaj Mamta , Mahor Vaishali
Published: July 2023

Background and Aims:

Caudal block is among the most widely administered regional anesthesia in pediatric patients. The clinical signs and objective assessments are not fast and reliable enough to provide a good feedback. Perfusion index (PI) is considered as a sensitive marker to assess the efficacy of caudal block. We aim to assess PI as an indicator for success of caudal block in pediatric patients.

Material and Methods:

Sixty pediatric patients scheduled for elective surgery of lower abdomen and below were included. Patients were randomly allocated into two groups (n = 30): Group 1 received caudal block after general anesthesia and Group 2 only received general anesthesia. PI, heart rate, mean arterial pressure, and anal sphincter tone (AST) were recorded at 5, 10, 15, and 20 min following induction of anesthesia.

Results:

A persistent increase in the PI value was observed in Group 1 starting from 5 min till 20 min, as compared to Group 2, at all the time intervals. When mean PI was statistically compared between both the groups, it was found to be highly significant (P = 0.001). Group 1 patients have progressive laxity of AST which was found to be significantly different from Group 2 (P < 0.001).

Conclusion:

We have found that both PI and AST are good indicators for assessing success of caudal block onset in pediatric patients but AST took slightly longer time (~20 mins). Therefore, we conclude that PI is simple, economical, and noninvasive monitor that predicts the caudal onset much earlier than AST.
A prospective observational study to assess the efficacy of “SICK” score in pediatrics
Authors: Thangaraj Shalini , Veerappan Ilamaran , Karthik S. Venkatesh
Published: July 2023

Background:

There is a need for pediatric scoring systems to monitor the progress in clinical outcomes, which are noninvasive, reliable, and easily measurable.

Subjects and Methods:

This prospective observational study evaluated the utility of a prevalidated “SICK” score for the purpose of assessing the score’s efficacy in hospitalized children of age 1 month to 12 years.

Results:

Of the 531 cases, 145 (27.3%) were admitted to the pediatric intensive care unit (PICU) and 386 (72.7%) were admitted to the pediatric ward. The probability of PICU admission was 11.42 (95% confidence interval [CI] 6.3–20.7) when the “SICK” score was ≥2. Children with a score ≥2 had a significantly longer duration of stay (mean difference = 45.58 h, 95% CI [30.65–60.51], P = 0.001). The score performed with an area under curve of 0.691 for a cut off score. The positive predictive value of the score is 73.53% (95% CI 62.66–82.13) and the negative predictive value is 79.48% (95% CI 77.45–81.37).

Conclusions:

The score performed reasonably well in our center for a profile of moderately sick children and can be recommended to be used as an effective triaging tool in a similar setting.
Ventricular empyema presenting as a complication of pneumococcal meningitis in a toddler
Authors: Muthusamy Parthasarathi , Subramaniam Madhumitha Chellappan , Palaniappan Ayyammal , Shanmugam Ponnusamy , Rabindranath Balasenthilkumaran Meda , Ramakrishnan Balavinoth , Ramalingam Ramakrishnan Tirupur Chinnappan
Published: July 2023

Streptococcus pneumoniae is a major pathogen in the pediatric population causing life-threatening infections ranging from pneumonia and meningitis to sepsis, and it is now a vaccine-preventable infection. Recently, pneumococcus is emerging as a cause of multidrug-resistant infection, resistant to ≥3 classes of antibiotics. Here, we discuss a case of ventricular empyema in a toddler due to S. pneumoniae. He was not vaccinated against pneumococcus. He had ventriculitis, ventricular empyema, and obstructive hydrocephalus. He was managed with external ventricular drainage of pus, followed by a ventriculoperitoneal shunt, and received 6 weeks of intravenous antibiotics, followed by oral antibiotics. He recovered with residual neurological sequelae and showed an improvement on follow-up visits.
Interaction between organic substrates of the southern region of the Ecuadorian Amazon and the presence of Eisenia foetida
Authors: Ramírez-Iglesias E. , Gualán R. , Guayanay V. , Ramírez-Iglesias JR.
Published: July 2023

This study aimed to evaluate the possible interaction between the chemical properties of some organic substrates of the southern region of the Ecuadorian Amazon and the development and reproduction of the red earthworm (Eisenia foetida), to obtain a bioproduct that can be used as organic fertiliser by producers of the region. The treatments used in the experience were: domestic organic waste (DOW), guinea pig excreta (GPE) and sugar cane waste (SCR), the control (CT) was a clay loam soil from the area. The chemical characterisation of the substrates was carried out before and during the introduction of the earthworms. After the pretreatment period (15 days), 30 individuals of E. foetida were placed in each bed, totalling 360 individuals. Initially, all the substrates showed low nutritional contents, as well as high C/N ratios, a trend that was maintained until the end of the experiment. After 25 days of composting, it was observed that the GPE treatment showed a pH close to neutrality, as well as greater nutrient availability. GPE and DOW were the organic residues with the best conditions for the development of E. foetida. After 45 days of the introduction of the earthworms, the vermicompost obtained could already be used as organic fertiliser, given the availability of nutrients.
Case Report: Leptospirosis after a Typhoon Disaster Outside the Endemic Region, Japan
Authors: Yamamoto Yukichika , Hagiya Hideharu , Hayashi Ruiko , Otsuka Fumio
Published: July 2023

Leptospirosis is a zoonotic disease that primarily affects people in tropical and subtropical areas worldwide. Owing to the temperate climate of Japan, leptospirosis is not endemic across the country. Domestic cases of leptospirosis have been mainly reported in Okinawa and the southwestern subtropical islands, but not in the other regions. Here, we describe a case of leptospirosis that developed and was diagnosed outside the domestically endemic region. Notably, disease onset occurred shortly after the patient experienced a flood after a typhoon disaster. With global warming, the international prevalence of leptospirosis may change. Physicians outside currently endemic areas must be aware of this tropical disease.
SOSIALISASI BEASISWA FULBRIGHT FOREIGN LANGUAGE TEACHING ASSISTANT (FLTA)
Authors: Agung I Gusti Ayu Mahatma , Putri Prisna Aswarita
Published: July 2023

Beasiswa memiliki peranan penting dalam meningkatkan kualitas sumber daya manusia suatu bangsa. Akan tetapi, manfaat beasiswa belum dirasakan secara merata di Indonesia. Hal ini disebabkan oleh terbatasnya informasi tentang beasiswa. Oleh karena itu, sosialisasi beasiswa perlu dilakukan secara berkala untuk memberikan informasi kepada masyarakat. Tujuan dari kegiatan sosialisasi ini adalah memberikan informasi mengenai beasiswa FLTA serta memberikan kesempatan bagi peserta sosialisasi untuk bertanya langsung kepada narasumber mengenai proses pendaftaran beasiswa. Sosialisasi beasiswa FLTA ini diselenggarakan oleh American Indonesian Exchange Foundation (AMINEF) secara daring dan diikuti oleh 25 peserta yang terdiri dari guru, dosen, dan mahasiswa. Di akhir acara, peserta diminta untuk mengisi survei melalui Google form sebagai suatu bentuk evaluasi kegiatan. Berdasarkan hasil survei tersebut, 95% peserta menyatakan bahwa sosialisasi beasiswa ini bermanfaat dan informatif. Melalui kegiatan ini, peserta mendapatkan informasi tentang beasiswa FLTA serta memahami teknik menulis esai beasiswa. Kegiatan sosialisasi beasiswa ini dapat memotivasi peserta untuk mendaftar beasiswa FLTA sehingga nantinya manfaat beasiswa ini dapat dirasakan secara lebih merata di masyarakat
PKM BUMDES JOHAR MANDIRI JAYA
Authors: Nasution Umar Hamdan , Rangkuti Sahnan , Iskandar Eddy , Zahri Cut , Junaidi Listya Devi , Rahman Arif
Published: July 2023

Bumdes Johar Mandiri Jaya merupakan Badan Usaha Milik Desa yang berada di Desa Pematang Johar. Adapun usaha yang dijalankan yaitu penyediaan ATK, foto copy, BRI LINK, Batik Sawah, unit usaha WIFI (HOTSPOT), layanan pembayaran Sistem Online dan wisata Sawah. Berbagai masalah yang terjadi pasca pandemic covid-19 lalu. Potensi desa yang ada tidak terkelola secara maksimal sehingga membuat masyarakat di desa Pematang Johar tidak sejahtera. Solusi yang tawarkan oleh tim pengabdi kepada Bumdes johar mandiri jaya yaitu memberikan pelatihan pengelolaan potensi desa, penyusunan laporan studi kelayakan bisnis, pemasaran produk desa, pengelolaan keuangan Bumdes, pengelolaan Manajemen BumDes dan Strategi pemasaran digital produk dan jasa. Program Pengabdian dilaksanakan pada hari Sabtu tanggal 08 April 2023 yang dilakukan via zoom meeting dengan peserta sebanyak 40 orang. Metode pelaksanaan yang dilakukan yaitu dengan memberikan pelatihan kepada peserta sesuai dengan materi pelatihan yang dibutuhkan oleh mitra. Hasil evaluasi dari pelatihan yang dilaksanakan yaitu meningkatnya pemahaman para peserta terhadap materi yang telah diberikan. Selanjutnya tim pengabdi akan melakukan pendampingan terhadap Bumdes dan UMKM yang ada di pematang Johar
Salud, educación y economía de la ciudadanía. Interrogantes sobre la inversión pública per cápita y su impacto en el índice de desarrollo humano
Authors: De Bracamonte Morales Pedro Jesús , Esquerre Ávila Guadalupe Asunción , Chang Pardo Figueroa Cruz Akemy , Guarniz Benites Olinda Carolina , Luis Grados Carlos Alberto
Published: July 2023

El desarrollo humano es uno de los temas primordiales a nivel global, es así que el Programa Nacional de las Naciones Unidas para el Desarrollo (PNUD) establece un indicador que denomina índice de Desarrollo Humano (IDH) el cual mide tres aspectos importantes tales como salud, educación y economía, como contraparte el Estado brinda bienes y servicios a la ciudadanía debiendo ser un agente importante para el desarrollo humano; es por ello que la presente investigación tiene como propósito determinar el impacto de la Inversión Pública Per Cápita en el índice de Desarrollo Humano, y en cada uno de sus tres factores, a fin de contar con un estudio que permita tomar mejores decisiones en aras de mejorar la calidad del gasto público. En esa línea de ideas, el presente trabajo presentará como se encuentra el índice de Desarrollo Humano a nivel latinoamericano, nacional y regional, posteriormente se analizará la Inversión Pública Per Cápita a nivel nacional y regional. El presente estudio se desarrollará en la Región La Libertad – Perú aplicando pruebas estadísticas para lograr el propósito de la investigación.
Omani Families Caring for a Member with Mental Illness: A Descriptive Qualitative Study
Authors: Aldiabat Khaldoun , Alsrayheen Enam A. , Alshammari Muna , Le Navenec Carole-Lynne , Griscti Odette
Published: July 2023

The aim of this qualitative descriptive study was to gain an in depth understanding and knowledge regarding how Omani families care for a member with mental illness including how they supported the later in self-care activities. Data was collected from participants using a purposive sample consisting of ten family caregivers whose member was in Sultan Qaboos University Hospital in Muscat. Each caregiver participated in one semi-structured interview. The interviews were analyzed using qualitative content analysis. The findings included two major themes: The first theme was “caring and empowering with empathy, love, and understanding.” The second theme was “self-denial and giving without limitations.” In conclusion, Omani family caregivers for a mentally ill family member provided optimum level of care to help and empower their family members to manage the mental illness. However, in so doing, those caregivers denied and neglected themselves for taking care of their mentally ill members. Several appropriate clinical interventions and policies are needed to support those family caregivers, to create a situation recently referred to as becoming “care partners.”
Engaging Students in Qualitative Research Practice and Understanding through Constructionist Perspectives: Socially Constructed Qualitative Research Pedagogies
Authors: Yanto Eliha Sutisna , Ramdani Junjun Muhamad
Published: July 2023

A growing number of books have explored how teachers teach students' qualitative research in second or foreign language classroom contexts step by step. It is rare, however, to find a book on research methods that includes a social constructionist approach to reflective and experiential learning for conducting qualitative research to help students become good qualitative researchers. To fill this void, Janet C. Richards, Audra Skukauskaitė, and Ron Chenail wrote a book entitled Engaging Students in Socially Constructed Qualitative Research Pedagogies (2022). This book is an important, forward-thinking, and useful resource for the rapidly expanding field of qualitative research pedagogy. In addition, it is applicable to a broader range of active teaching in higher education. The authors discuss a constructionist approach to education. The book is separated into three sections, each of which describes a unique strategy or method for actively incorporating students into qualitative research. Chapter authors with backgrounds in six countries (the United States, Lithuania, Canada, Israel, China, and Russia) present imaginative, practical, and theoretical methods for actively incorporating students in the research learning process. The book will be of interest to students, who will appreciate the inclusion of student projects and authentic scenarios through which instructors assist student learning and qualitative research. The book will also be interesting for instructors who want to improve their pedagogy and find new ways to teach.
Penilaian Kebugaran Jasmani Siswa Kelas V di SD Negeri Sragen 6 Kabupaten Sragen
Authors: Agus Mukholid  , Andri Arif Kustiawan  , Agus Pribadi  , Dicky Alfindana  , Hadiono
Published: July 2023

Berdasarkan hasil penelitian menggunakan Tes Kebugaran Pelajar Nusantara, ditemukan bahwa tingkat kebugaran jasmani siswa kelas V di SD Negeri Sragen 6 Kabupaten Sragen telah dievaluasi. Hasil pengukuran indeks massa tubuh (IMT) pada 20 siswa menunjukkan bahwa 2 siswa (10%) memiliki status gizi kurang, 12 siswa (60%) berada dalam kategori gizi baik, 5 siswa (25%) mengalami kelebihan gizi, dan 1 siswa (5%) mengalami obesitas. Dari hasil itu, bisa di simpulkan bahwa jumlah siswa dengan kategori gizi baik adalah yang tertinggi, yaitu sebanyak 12 anak dengan persentase 60%. Hasil dari Test V-Sit and Reach didapatkan hasil yang tertinggi yaitu pada kategori baik sekali terdapat 14 siswa dengan persentase 70%. Hasil ini berbanding terbalik dengan test Sit-up dimana kategori yang paling tinggi adalah Rendah dan Cukup dengan total jumlah anak 14 dan persentase sebesar 70%. Pada hasil Test Squat Trust, kategori baik sekali memiliki persentase yaitu 45% dengan jumlah siswa sebanyak 9. Berbeda dengan hasil dari PACER Test, justru kategori tertinggi yaitu sangat rendah dengan persentase sebesar 35% dan jumlah siswa sebanyak 7. Berdasarkan data hasil 4 item Tes Kebugaran Pelajar Nusantara menunjukan bahwa hasil nilai proporsi dari perhitungan menunjukkan nilai 3,1 dimana nilai tersebut termasuk dalam kategori Baik.
МАЛОРАСХОДНАЯ ПАРОВАЯ ТУРБИНА ДЛЯ ПГУ НА БАЗЕ ГТУ CAPSTONE C200
Authors: Филиппова В. М.
Published: July 2023

В работе представлен вариантный расчет паровой части ПГУ, расчет цилиндров высокого и низкого давления малорасходной турбины.
ИССЛЕДОВАНИЕ ОСОБЕННОСТЕЙ КВАДРАТУРНОЙ
МОДУЛЯЦИИ QAM
Authors: Антоненко А. А. , Волхонская Е. В.
Published: July 2023

В статье приведены результаты экспериментального исследования помехоустойчивости радиосигналов с квадратурной амплитудной модуляцией при наличии в канале передачи белого шума. Сравнительный анализ экспериментальной оценки вероятности ошибки на символ от отношения сигнал/шум в канале и теоретической зависимости имеет достаточную сходимость результатов. В ходе исследования выявлено, что требуемое отношение сигнал/шум в канале для качественной передачи информации посредством 16-QAM варьирует в зависимости от энергии битовой комбинации, предназначенной к передаче.
ANALISIS BEBAN KERJA MENTAL KARYAWAN DEPARTEMEN PERENCANAAN PRODUKSI METODE NASA-TLX DI PT. XYZ
Authors: Nurcahyo Handika Dwiki , Prasetyo Rian
Published: July 2023

The quickly development of the industrial world requires to think hard, especially in the industrial sector as a form of fulfilling a system that can keep up with the accelerating pace of industry today. Employees as a company resource are expected by the company to always pay attention to the conditions of employees to fulfill optimal resources. PT. XYZ with fluctuating customer requests, so it can cause fatigue when demand rises. In the work process, employees in completing work in the production planning department when production planning process problems often occur such as material arrivals not according to estimates, product defects, and late manufacturing drawings. This can lead to work processes piling up at the end and being chased by the timely completion of orders that have been scheduled for delivery it can cause excessive workload when working when complicated constraints occur. This research will be carried out by analyzing the mental workload in the production planning department. The purpose of this study was to find out how much mental workload there is in the production planning department so that a measurement of the mental workload of employees is obtained to be able to find out the amount of workload of employees in the production planning department. The limitations of this study only analyze the mental workload of employees with structural positions in the production planning department. Based on the calculation of the final NASA-TLX score, 13 respondents in the Production Planning Department had an overloaded workload. Based on the calculation of the proposed mental workload improvement, the total score of the old mental workload was 74.102 in the overload category to become a new mental workload of 56.666 in the optimal category with the addition of 4 employees in structural positions.
Detection of Renal Stones by Ultrasonography
Authors: Asif Nishat Um-e-Kalsoom , Ali Abid , Irram Saadia , Mazhar Mehlab , Maqsood Mahnoor , Muzafar Saba , Ashraf Nadia , Noor Ayesha
Published: July 2023

Background: Kidney stones also known as renal stones are hard deposits made of minerals that develop in the urinary system or kidneys. Numerous symptoms, including excruciating pain in the lower back, abdomen, or groin, nausea, and vomiting, can be brought on by renal stone. Objective: To evaluate the accuracy of ultrasonography for the presence, location, and site of stones in patients with acute renal colic Methods: This research was conducted in the radiology department of the Jalal Pur Diagnostic Centre. Data were acquired from October 2022 to March 2023.100 patients were included in the study. Patient-informed permission was acquired following the ethical standards outlined by the research committee. Results. The study shows that 74% of patients have unilateral renal stones while 26% have bilateral renal stones. About 43 people had urolithiasis on the left side. The majority of stones were present in the lower pole of the kidney. Conclusion: Ultrasonography can be utilized as a primary evaluation technique in patients presenting with acute renal colic. Males are most commonly affected by renal stones than females and patients between the ages of 31 and 45 are the most usually affected.
Assessing Knowledge, Attitudes, and Practices: Regarding Hepatitis B Infection and Vaccination Among Healthcare Professionals at AL-Salama Hospital, Ameria, Baghdad City: A Cross-Sectional Investigation Conducted in October-November 2022.
Authors: Atshan Fawzi Hashim , Al-Khayyat Basil Abdullrazzaq Saadallah , Ghali Ehab Jumaa , Alsherees Hashim
Published: July 2023

Hepatitis B Virus (HBV): A High-Risk Infection for Healthcare Workers (HCWs) , Healthcare workers (HCWs) are at an increased risk of contracting the highly dangerous hepatitis B virus (HBV) due to their frequent exposure to contaminated bodily fluids, particularly blood. Implementing precautionary measures such as personal safety protocols and vaccination can effectively prevent HBV infection. Objective: 1- Evaluation of Healthcare Professionals' Knowledge, Attitudes, and Practices (KAP) Regarding Hepatitis B Infection and Vaccination.
2- Evaluating Immunization Status of Healthcare Workers (HCWs) in Al-Salama-Ameria Hospital, Primary Care, and Specialist Dental Care Centers in Relation to Hepatitis B Virus (HBV). Materials and methods: In October and November 2022, a cross-sectional study was conducted at Al Salama Hospital (90 participants), primary care centers (44 participants), and specialist dental care centers (20 participants) in Ameria, Baghdad. A self-administered, structured questionnaire was used to collect information, including the knowledge, attitudes, and practices (KAP) of healthcare workers (HCWs) as well as their demographic details. The study data were analyzed using descriptive statistics, including frequencies, proportions, and percentages, with the assistance of Excel software. Verbal consent was obtained from each participant, and their identities were kept anonymous throughout the study. Results: Our research comprised a total of 154 healthcare workers (HCWs), consisting of 59 A medical facility comprised of 95 medical staff and 95 paramedical staff, possessing a collective wealth of knowledge. score among the participants was 68%, indicating a moderate level of knowledge. In terms of attitude, the overall score was 75%, indicating a positive attitude towards hepatitis B virus (HBV) infection and vaccination. However, the overall practice score was 58%, indicating a need for improvement in implementing preventive measures. Within the medical staff, a mere 15% had undergone HBV screening, while a significant 67% had successfully received the recommended three doses of vaccination. among the paramedical staff who had not been previously screened for HBV, only 37% had completed the three doses of vaccination. Conclusion: The findings of the study indicated that healthcare workers (HCWs) had a higher overall attitude score (75%) compared to their knowledge (68%) and practice (58%) scores. However, the rate of vaccination, particularly among paramedical staff, was low.
Analysis Of The Effectiveness Of Implementing Voluntary Disclosure Programs In Cicadas Bandung
Authors: Purwanti Meilani , Luhung Budi
Published: July 2023

Taxpayer awareness and compliance in terms of tax payments are still low and on the other hand there are also several Indonesian assets that are outside the territory of the Unitary State of the Republic of Indonesia. The target of increasing state revenue every year causes the government to try to make new policies related to the Voluntary Disclosure Program (Tax Amnesty Volume II). The purpose of this study is to see, know and analyze the effectiveness of the implementation of the Voluntary Disclosure Program policy (Tax Amnesty Volume II) as stated in HPP Law Number 7 of 2021 at KPP Pratama Bandung Cicadas.

This type of research is qualitative with a descriptive approach where the goal is to describe the situation systematically. Data analysis aims to simplify the results of data processing, making it easy to read and interpret. The data used are primary data with field study research techniques, namely interviews and documentation.

The results of this study show that the effectiveness of the implementation of the Voluntary Disclosure Program (Tax Amnesty Volume II) runs well and effectively. This can be seen from the revenue that increased significantly by 130% in 2022 and the number of taxpayers who paid PPS of 807 WP, with the number of taxpayers who paid PPS effectively because considering its voluntary nature there is no target set. The Voluntary Disclosure Program (Tax Amnesty Volume II) is also based on clear legal protections so as to increase taxpayers' confidence in new regulations made by the government.
Interculturality in St. Paul University Philippines
Authors: Lappay Allan Peejay M.
Published: July 2023

This study discusses the interculturality of St. Paul University Philippines along its educational designs. Utilizing the descriptive research method and integral approach, it relates the convergence and the interaction of the members of the academic community with diverse profile manifested through their cultural backgrounds and faith affiliations. It also demonstrates SPUP’s practices along learning environment, policies and regulations, and programs and activities towards intercultural engagement. Lastly, it exhibits the ability of SPUP to foster a cultural experience integral of the Paulinian Core Values, namely: charity, charity, charism, commission, and Christ.
Implementación de varios niveles de harina de botón de oro (Tithonia diversifolia) para cuyes (Cavia porcellus) en etapa de engorde
Authors: Santana Alvarado Wilver , Monge Freile Marlon Fernando , Durazno Delgado Leonilo Alfonso , Muñoz Mestanza Roberto
Published: July 2023

La investigación se realizó en la parroquia Valle Hermoso, localizada en el km 10 Vía los Bancos  Santo Domingo, provincia de Santo Domingo de los Tsáchilas. El objetivo de la investigación fue determinar los parámetros productivos (peso inicial, peso final, ganancia de peso y mortalidad). Se aplicó un Diseño Completo al Azar con 4 tratamientos (0%, 10%, 15% y 20% de harina de botón de oro) 10 cuyes por unidad experimental. Se aplicó la prueba de rangos de significancia de Tukey (P≤0,05). En peso inicial sin de harina de botón de oro en dieta el que mayor peso presento fue T1 700.8 g, el peso final T1 fue el que mayor peso mostró con el 10 % de harina de botón de oro con un peso de 805 g,  la mayor ganancia de peso fue del T1 (10% harina botón de oro) con 104. 2 g siendo altamente significativo y para la conversión alimenticia lo registró el tratamiento T3 (20%  harina botón de oro) con 3.81. Los tratamientos presentaron la misma mortalidad con promedio de 1 cuy. La mejor relación beneficio/costo fue T1:10% harina de botón de oro con $ 1.15 dólares representando una utilidad de 0.15 ctvs.
Aplicación Design Thinking y Agile Inception para el desarrollo de microempresas de servicio de cafetería
Authors: Cuadrado Torres Luisa
Published: July 2023

Design Thinking, es una metodología basada en ideas, empatía y experimentación, centrada en las personas. El Agile Inception, facilita la tarea de desarrollar proyectos de una forma rápida y flexible. El artículo analiza la aplicación del Design Thinking y el Agile Inception en las microempresas que ofrecen servicios de cafetería en el cantón Manta, para la generación de innovación y una propuesta de valor para sus clientes. La metodología comprendió un diseño no experimental, con enfoque mixto, de tipo exploratorio, descriptivo y explicativo. El enfoque cualitativo abarcó entrevistas a un experto y 5 administradores de negocios de cafeterías, mientras que, en el cuantitativo, se efectuó una encuesta a 120 personas, utilizando un muestreo aleatorio simple.Mediante un análisis de diversas investigaciones se identificó que las herramientas del Design Thinking más utilizadas son: mapa de empatía, lluvia de ideas, encuestas y test de usuarios,prototipo rápido y entrevistas.Como resultado del estudio se evidenció que existe poca innovación y utilización de las metodologías en emprendimientos de cafeterías y la probabilidad de que las personas recomienden a un amigo o familiar que las visiten es un 24%, siendo la ubicación y la calidad los aspectos más críticos tanto para detractores como para promotores. En cuanto al Agile Inception, se identificó que previo al lanzamiento de un producto, estos negocios han aplicado en alguna medida 5 de los 10 pasos contemplados en esta herramienta, sin que haya existido una visión clara de todos los aspectos fundamentales para construir una propuesta de valor.
ESTRATEGIA DIDÁCTICA PARA EL USO DE APRENDIZAJE EN EL LÍMITES Y CONTINUIDAD DE LOS ESTUDIANTES DE SEGUNDO DE BACHILLERATO DE LA UNIDAD EDUCATIVA FISCAL PAJÁN
Authors: Gonzabay Villafuerte Celin Francisco
Published: July 2023

La excelencia académica depende en gran parte de las formas que adopte el docente para orientar el proceso de enseñanza y aprendizaje, es decir, la claridad necesaria para el desarrollo de las actividades educativas; por el contrario, la falta de aplicación de estrategias didácticas y el uso indebido de los medios educativos conllevan a una cultura de inconciencia y escaso desarrollo de la inteligencia en los alumnos y docentes. El objetivo de este estudio es analizar el uso de herramientas didáctica por los docentes y determinar el nivel motivación que tienen los estudiantes de segundo de bachillerato acerca del aprendizaje de límites y continuidad en la Unidad Educativa Fiscal Paján. La metodología responde a una investigación con enfoque mixto de tipología descriptiva, sintético y estadístico, con la aplicación del instrumento de encuesta en la que participaron 90 estudiantes de segundo de bachillerato y se aplicó una entrevista a 2 docentes. Los resultados revelan que los docentes no utilizan las actividades lúdicas como herramienta para favorecer el aprendizaje en el salón de clase además de que existe una deficiente dotación de recursos para el aprendizaje de los alumnos que impide la realización de actividades didácticas, y la dificulta el buen uso de los recursos educativos en el aula de clase y con ello se limita el desarrollo del aprendizaje significativo en el aprendizaje en el límites y continuidad.
Dampak Kredit Usaha Rakyat (KUR) terhadap Kesejahteraan Penerima KUR di Indonesia
Authors: Adha Rendy Bayu
Published: July 2023

Kemiskinan merupakan masalah multidimensional dan tantangan pembangunan dunia. Meskipun pembangunan di Indonesia telah berhasil menurunkan tingkat kemiskinan secara signifikan, namun pemerintah masih menempatkan pengentasan kemiskinan sebagai salah satu tujuan pembangunan, di antaranya dengan melindungi sektor-sektor usaha mikro, kecil dan menengah. Berbagai masalah masih dihadapi UMKM, salah satunya adalah keterbatasan akses keuangan atau modal. Untuk itu, pembiayaan mikro seperti program Kredit Usaha Rakyat (KUR) dijalankan pemerintah Indonesia. Penelitian ini menggunakan pendekatan kuantitatif dengan data Susenas BPS tahun 2020. Metode analisis Propensity Score Matching (PSM) digunakan untuk mengevaluasi dampak program terhadap pengeluaran rumah tangga yang terdiri dari pengeluaran makanan dan pengeluaran bukan makanan. Hasil penelitian ini menemukan adanya dampak positif dan signifikan dari program KUR terhadap pengeluaran rumah tangga penerima KUR di Indonesia. Dampak program KUR terhadap pengeluaran bukan makanan lebih besar yaitu sekitar 18,3%-28,1% dibandingkan dampaknya terhadap pengeluaran makanan sebesar 9,5%-14,2%. Hal ini menunjukkan tingkat kesejahteraan yang lebih baik dimiliki oleh rumah tangga yang berpartisipasi dalam program KUR. Namun, analisis statistik menunjukkan bahwa program ini sendiri belum sepenuhnya berpihak pada rumah tangga miskin, terlihat dari partisipasi program didominasi oleh rumah tangga kelas menengah dan tinggi. Untuk itu, pemerintah perlu memperluas jangkauan program bagi rumah tangga miskin dan bagi jenis usaha produktif seperti pertanian dan masyarakat di pedesaan.