bluuebunny/crossref_metadata_2025 huggingface dataset:
Abordagem da insónia secundária do adulto nos cuidados de saúde primários.
Authors: Cavadas Luís Filipe , Ribeiro Lúcia
Published: July 2022

Insomnia is the most common sleep disorder in adults, with secondary insomnia being the most prevalent. This sleep disorder is associated with important medical and social consequences. The General Practitioner (GP) plays a key role in the diagnosis of insomnia, which may affect about 69% of their patients in the PHC (Primary Health Care).Recognize the differential diagnosis of secondary insomnia in adults, evaluate and manage these patients in the PHC, appropriately use the treatments available and meet the criteria for referral.Bibliographic search in MEDLINE databases, and evidence based review databases, using the MeSH terms: Primary Health Care, Sleep Disorders, Insomnia, for articles published since January 2000 until July 2009, in English, Portuguese, French and Spanish. Index de Revistas Médicas Portuguesas and scientific societies dedicated to sleep disorders were searched.Mood and anxiety disorders are the main co-morbidities associated with secondary insomnia, being present in 30% to 50% of patients with insomnia. The medical pathology and substance abuse are present respectively in 10% of patients. It is essential a proper clinical history, with a history of sleep, sleep diary and the partner information. There is evidence that the combination of specific pharmacological treatments (benzodiazepines and the benzodiazepine receptor agonists) with the nonpharmacological (cognitive-behavioral therapy) may be useful in secondary insomnia, as co-adjuvant treatment of the underlying disease. There are several treatment options with their indications and adverse effects. The criteria for referral should be defined according to the availability of human resources.Due to the high prevalence and the serious consequences of secondary insomnia in adults, it must be systematically managed by the GP. It is important to know and to use non-pharmacological therapy in GP consultation, because this therapy was shown to be important in treating this type of insomnia. The GP must know the precise indications for pharmacological treatment and criteria for referral.
Hiperplasia congénita da suprarenal de expressão tardia por deficiência de 21-hidroxilase: revisão da literatura e estudo genético preconcepção de cinco casais.
Authors: Vieira Alexandra , Paiva Sandra , Baptista Carla , Ruas Luísa , Silva Júlia , Gonçalves João , Carrilho Francisco , Carvalheiro Manuela
Published: July 2022

The deficiency of the enzyme 21-hydroxylase (21-HO) is responsible for about 90% to 95% of all cases of congenital adrenal hyperplasia (HCSR). This disorder is one of the most frequent hereditary illnesses of autosomal recessive trait. The illness can be presented in two clinical forms: 1 - classic, subdivided in saltwasting form and simple virilizing form; 2 - nonclassic or late-onset. The severity of the illness is correlated with the degree of enzymatic activity of 21-HO, which depends on the type of mutation that occurs in gene CYP21A2. The late onset congenital adrenal hyperplasia is that one where the enzymatic blockade is less intense. The clinical is variable: precocious pubarche, polycystic ovaries, hirsutism, oligoamenorrhea, acne and infertility. Gold standard for the diagnosis of late onset congenital adrenal hyperplasia consists on the test of the tetracosactide, considering itself diagnostic positive when 17-hidroxiprogesterona (17-OHP) is higher of 10-15 ng per mL. Many patients don't need treatment; however, if necessary, such a treatment essentially consists on the Administration of glucocorticoids and antiandrogens. Considering that affected individuals and the carriers may have a severe mutation in CYP21A2, they can have descendents with the classic form (if their partner is also a carrier of a severe mutation), it is mandatory the genetic study of the couple. The authors illustrate the importance of this genetic study through five clinical cases, whose common link is the desire to have children, as well as the presence on the feminine element of late onset congenital adrenal hyperplasia. The genetic study of the couple allows adequate pre-conception counseling and also prevents the use of corticoids throughout the pregnancy (if there's no risk of descendents being affected with the classic form). This aspect must be had in account in programming the pregnancy, in order to prevent therapeutics and unnecessary distrusts.
Síndroma de Stevens-Johnson e necrólise tóxica epidérmica: um estudo retrospectivo de 15 anos.
Authors: Moniz Paula , Casal Diogo , Mavioso Carlos , Castro José Videira e , Almeida Maria Angélica
Published: July 2022

Stevens-Johnson Syndrome (SJS), Overlap Syndrome (OS) and Toxic Epidermal Necrosis (TEN) are rare medical emergencies associated with a high morbidity and mortality. The literature on the characteristics of these diseases in Portugal is scarce. A retrospective study was conducted based on the clinical notes of the 20 patients admitted to São José Burn Unit in the previous 15 years with the diagnosis of SJS, OS or TEN. Most patients had TEN (65%), followed by OS (25%) and SJS (10%). Average age was 57,1 ± 19,0 years. The mean duration of stay in the Burn Unit was 12,6 ± 7,8 days. Mortality was 50%, being significantly higher than the 16,4% overall mortality in the general Burn Unit population in the same period (p < 0,01). The mean surface area involved was 43,9 ± 28,6 %. Allopurinol was the causal agent most frequently implicated (35%) followed by UV light exposure (15%). Fourteen patients (70%) were treated with steroids in the first days, whereas six patients were treated conservatively (30%). Mortality was inferior in the patients treated with steroids (42,8 vs. 66,7%), even though this difference did not reach statistical significance. Infection rates were not significantly different between the two groups. SCORTEN score proved to be a good predictor of mortality. Further studies are needed to reduce mortality in these diseases.
Massa Abdominal Sangrante
Authors: Lourenço Cândida Sofia , Basso Susana Patricia , Dionissio Maria Assunção
Published: July 2022

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Tumefacção Frontal: Desafios de Diagnóstico
Authors: Rubino Gina , Correia Alexandre , Rodrigues Fernanda
Published: July 2022

Capnocytophaga spp. are part of the oral flora of humans and animals, being responsible for skin and soft tissues infections and invasive infections. Microbiological identification can be difficult due to its slow growth. We present a case of infection caused by this bacteria in the form of an extracerebral intracranial abscess, presenting as a frontal mass that posed some diagnostic challenges. A surgical drainage was performed together with antibiotic therapy with favourable outcome. This microorganism was identified in the second week of treatment and then a careful history revealed a dog bite days prior to the initial symptoms. This could have been the site of entry to a posterior focalization.
Mecanismos de Resistência aos Inibidores da Tirosina Cinase BCR-ABL
Authors: Diamond Joana , Da Silva Maria Gomes
Published: July 2022

Since the introduction of imatinib mesylate for the treatment of chronic myeloid leukaemia, impressive clinical responses were observed in the majority of patients in chronic phase. However, not all patients experience an optimal response to imatinib mesylate or even to the more potent, second generation tyrosine kinase inhibitors. Furthermore, responses are not sustained in a number of patients, and it is yet unclear whether the inhibitors can be safely discontinued in patients who achieve long-term remission. The emergence of resistance to second generation tyrosine kinase inhibitors has become a significant problem that led to extensive studies on the causal mechanisms. This review will describe our current state of knowledge on why and how chronic myeloid leukaemia cells can develop resistance to second generation tyrosine kinase inhibitors.
Psiquiatria de ligação: desenvolvimento internacional.
Authors: Cardoso Graça
Published: July 2022

The development of consultation liaison psychiatry is linked to the integration of mental health services in the general health services. Its beginning occurred simultaneously in North America and in Europe, although following paths that differed in each country, and were related with the organization of health services. Nowadays, consultation liaison psychiatry's importance and development are fully established. Among the different challenges it currently faces, the need for a better articulation between hospital and primary care services, is the most preeminent.
Allogeneic stem cell transplantation in patients with myelodysplastic syndrome: outcome analysis according to the International Prognostic Scoring System.
Authors: Rubio S , Martins C , Lacerda J F , Carmo J A , Lourenço F , Lacerda J M F
Published: July 2022

We determined the outcome of patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML) after allogeneic stem cell transplantation according to their international prognostic scoring system (IPSS) risk categories at diagnosis. A total of 11 females and 7 males, with a median age of 45 years, were transplanted. With a median follow-up of 60 months, the 6-year actuarial event-free survival (EFS) for Less Advanced (Low and Intermediate-1 risk IPSS) and Advanced (Intermediate-2 and High risk IPSS) MDS was 71.4% and 43.6%, respectively (p=0.002). We did not observe a difference in EFS depending on cytogenetics at diagnosis (good risk 53.8% Vs intermediate and high risk 53.3%, p=ns), neither on the type of conditioning regimen used (myeloablative 50% Vs reduced intensity 52.2%, p=ns). Our results support that IPSS score at diagnosis may be used to predict EFS in patients with MDS undergoing allogeneic SCT.
Development of an Educational Sustainability Assessment Model: Application of the Delphi Technique and Pilot Study
Authors: Chianchana Chaiwichit
Published: July 2022

The objective of this research was to develop an educational sustainability assessment model using the Delphi technique. The research participants were an expert panel and stakeholders of educational projects. The research instruments consisted of an open-ended questionnaire and assessment forms. The frequencies, medians, quartile deviations, means and standard deviations of the data were analysed. The research results found that the assessment framework for educational sustainability in the first round consisted of the following indicators: pre-conduct, process conduct, post-conduct and the criteria consisted of the possible opportunities in sustainability (for pre-conduct and process conduct) and true sustainability (for post-conduct). The second round of assessment indicators and criteria were high, and in the third round they were very high. A pilot study of the feasibility of sustainability (pre-conduct) found that this project had the opportunity to achieve sustainability at the highest level and all model assessment standards were at the highest level.
AGE AND BODY MASS INDEX IN TYPE I ENDOMETRIAL CANCER GRADE
Authors: Gilang Adi Firmansyah  , Dyah Fauziah  , Brahmana Askandar Tjokroprawiro3
Published: July 2022

Highlights:
1. The major risk factors for type I endometrial cancer, namely age and obesity, play a major role in the increase in this case and are thought to be related to the grade in these cancer patients.2. Type I endometrial cancer patients at Dr. Soetomo General Academic Hospital 2019-2020 are dominated by patients diagnosed at the age of 56-65 years, having an overweight body mass index (23-24.9 kg/m2).3. The patient's age and body mass index did not correlate with endometrial cancer type I grade.
Abstract
Background: The increase in obesity and life expectancy has contributed to type I endometrial cancer cases worldwide. Increased risk factors play a role in the increase of these cases. Objectives: To determine the relationship between age and BMI with the cancer grade. Material and Method: This research was a cross-sectional study. The data were obtained from the patient’s medical records. The sampling technique was total sampling. The analysis used was Spearman Rho correlation test for the relationship between age and BMI with cancer grade. Results: This study recorded 54 patients with type I endometrial cancer in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from 2019 to 2020. The patients were from the age group 56-65 years 25 patients (46.30%), 46-55 years 17 patients (31.48%), 36-45 years 8 patients (14.81%), 26-35 years 2 patients (3.7%), and >65 years 2 patients (3.7%). For BMI, the patients were overweight (23-24.9 kg/m2) 21 patients (38.89%), normal (18.5-22.9 kg/m2) 14 patients (25.93%), obesity (25-29.9 kg/m2) 12 patients (22.22%), and obesity II (≥30 kg/m2) 7 patients (12.96%). For grade, grade III were 22 patients (40.75%), grade II  20 patients (37.04%), and grade I 12 patients (22.22%). There was a weak, insignificant positive correlation between age with grade (ρ=0.116, 0.405>α=0.05) and a weak, insignificant negative correlation between BMI with grade (ρ=-0.206, 0.135>α=0.05). Conclusion: A total of 54 patients with type I endometrial cancer at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from 2019-2020 aged 56-65 years and overweight (23-24.9 kg/m2) with grade III cancer. The patient's age and BMI did not correlate with the patient's grade.
The Effect of University Students’ Internalized Shame on Social Anxiety: The Dual Mediating Effect of Maladaptive Cognitive Emotion Regulation and Self-compassion
Authors:   The Association of Korea Counseling Psychology Education Welfare, LEE Da-Yea , SONG WonYoung
Published: July 2022

The dual mediating effect was verified to investigate the relationship between internalizedshame, maladaptive cognitive emotion regulation, self-compassion, and social anxiety, and toprovide a basis for counseling and psychotherapy. Data from 290 college students wereanalyzed using SPSS 20 and AMOS 20. As a result, the final model in which maladaptivecognitive-emotional regulation and self-compassion acted as mediating variables in therelationship between internalized shame and social anxiety was adequate. The path ofmaladaptive cognitive emotion regulation was not significant, but the path of self-compassionwas significant. As a result of bootstrapping, the mediating effect of self-compassion betweeninternalized shame and social anxiety was significant, and the sequential dual mediating effectof maladaptive cognitive-emotional regulation and self-compassion was also significant. Basedon these results, the implication and limitations of this study were discussed.
The Effect of Socially Prescribed Perfectionism on the Career Preparation Behavior of College Students: The Mediating Effect of Grit and Achievement Motivation
Authors:   The Association of Korea Counseling Psychology Education Welfare, CHO Hye-Jin , KIM Mi-Sun , KIM Jeong-Eum , KIM Young-Seok
Published: July 2022

This study tried to examine the mediating effect of grit and achievement motivation on therelationship between socially prescribed perfectionism and career preparation behavior ofcollege students. To this end, an online survey was conducted for university students in Korea. A total of 359 questionnaires were used for the analysis, and the structural equation modelingwas applied as an analysis method. The results are as follows. First, it was found that gritcompletely mediated the relationship between social prescribed perfectionism and careerpreparation behavior. Second, grit and achievement motivation sequentially mediated therelationship between social imposition perfectionism and career preparation behavior. This studyis meaningful in that it can provide basic data for developing a career program that helpscollege students with strong social imposition perfectionism.
An azobenzene-based photothermal energy storage system for co-harvesting photon energy and low-grade ambient heat via a photoinduced crystal-to-liquid transition
Authors: Dong Liqi , Zhai Fei , Wang Hui , Peng Cong , Feng Yiyu , Feng Wei
Published: July 2022

Ambient heat, slightly above or at room temperature, is a ubiquitous and inexhaustible energy source that has typically been ignored due to difficulties in its utilization. Recent evidence suggests that a class of azobenzene (Azo) photoswitches featuring a reversible photoinduced crystal-to-liquid transition could co-harvest photon energy and ambient heat. Thus, a new horizon has been opened for recovering and regenerating low-grade ambient heat. Here, a series of unilateral para-functionalized photoinduced liquefiable Azo derivatives is presented that can co-harvest and convert photon energy and ambient heat into chemical bond energy and latent heat in molecules and eventually release them in the form of high-temperature utilizable heat. A straightforward crystalline-to-liquid phase transition achieved with ultraviolet light irradiation (365 nm) is enabled by appending a halogen/alkoxy group on the para-position of the Azo photoswitches, and the release of thermal energy is triggered by short-wavelength visible-light irradiation (420 nm). The phase transition properties of the trans- and cis-isomers and the energy density, storage lifetime and heat release performance of the cis-liquid are investigated with differential scanning calorimetry, ultraviolet-visible absorption spectroscopy, and an infrared (IR) thermal camera. The experimental results indicate a high energy density of 335 J/g, a long lifetime of 5 d and a heat release of up to 6.3 °C due to the coupled photochemical-thermophysical mechanism. This work presents a new model for utilizing renewable energy, i.e., the photoinduced conversion of ambient thermal energy.
A systematic review of fused deposition modeling process parameters
Authors: Ahmad NurFarrahain Nadia , Wong Yew Hoong , Ghazali Nik Nazri Nik
Published: July 2022

Fused deposition modeling (FDM) is an additive manufacturing technique with significant advantages, including cost effectiveness, applicability for a wide range of materials, user-friendliness and small equipment features. However, its poor resolution represents a hindrance for functional parts for commercial production. In this review, the key process parameters are presented with their factors and effects on the characteristics of FDM-printed polymeric products. Hence, better insights into the relationship between key parameters and three main printing characteristics, namely, surface roughness, mechanical strength and dimensional accuracy, in existing FDM research are provided. A conclusion that addresses the challenges and future research directions in this area is also presented.
Open innovation in SMEs a bibliometric literature review using VOSviewer
Authors: Nuryakin Nuryakin , Ngetich Brian Kiprop , Krishna B Valent
Published: July 2022

Purpose – The focus of this study is to evaluate the features of open innovation using data accessed from the Scopus online database. We are looking at two keywords: open innovation and SMEs.
Design/methodology/approach – The study measured a bibliometric analysis of 1,214 articles from 157 journals during 2007-2020.
Findings: The findings showed that the publication trend on open innovation kept increasing. The most cited article was Open Innovation in SMEs: Trends, Motives, and Management Challenges by Van de Vrande with 1,107 citations, followed by Lee et al. with 699 citations. The publication journal with the highest citation was Technovation and Research Policy. The United Kingdom and Italy were in the top-ranking countries for publications on this topic. The document citation category showed that Belgium ranked the highest with 1,990, followed by the Netherland with 1,212.
Research limitation/implications: This study provides a literature search on open innovation and has several limitations that require future study recognition. These limitations include that databases are limited to sources originating from one database only in data collection and data synthesis.
Practical implications: The practical implications provide benefits about open innovation, which can help SMEs understand open innovation and apply it as their preferred strategy in developing business. This study also allows SMEs owners and managers to understand open innovation as a strategic choice to consider as the concept is a part of the strategic intervention for their business.
Originality/value: This study provides the most influential contribution and impact on the research interest of open innovation that develops from various fields, including leading researchers and their home countries. Second, a co-citation analysis addressed the second question in this research study.
Knowledge of COVID-19 and online purchase intention: the role of health protocol and fulfilment
Authors: Sukardi Sukardi , Ismanto Deny
Published: July 2022

Purpose – This study analyses the relationship between knowledge of COVID-19 and the application of health protocols, fulfilment in the pandemic era and online purchase intention. This study also analyses the effect of health protocol and fulfilment on online purchase intention.
Design/methodology/approach – This study is a quantitative study with a student population in Yogyakarta. From the total population, 170 respondents were taken by random sampling method. The data in this study are primary data obtained through the distribution of questionnaires. From the data obtained, analysis was carried out using the Structural Equation Model method using Partial Least Square with Smart-PLS software.
Findings – The results of the analysis in this study indicate that knowledge of COVID-19 is able to have a significant influence on the implementation of health protocols and fulfilment, but knowledge of COVID-19 is not able to significantly influence online purchase intention. The results of the analysis also state that the health protocol is not able to have a significant effect on online purchase intention in students, while fulfilment is able to provide a significant influence on online purchase intention.
Research limitations/implications – For further research, it is expected to be able to examine more deeply online purchase intentions across generations and compare them. Further research is also expected to include several other variables that have a role in online shopping behaviour.
Practical implications – The results of the analysis in this study also provide recommendations for business people in this pandemic era to emphasize online buying and selling services. Online marketing is also more recommended because the more people understand about COVID-19, the less they do activities outside the home, so the most effective marketing is through social media which is accessed by the public every day.
Originality/Value – In contrast to previous studies, this study proposes a model of people's behaviour in shopping online. The analysis in this study formulates the relationship between knowledge of COVID-19, health protocol, fulfilment and online purchase intention.
Multimedia Products in Library and Information Service: Domestic and Foreign Experience
Authors: Savkina S. V.
Published: July 2022

User service by means of multimedia is an actual direction of library practice. Modern forms of interaction with the user have wide functionality, attract readers, form the image of an information institution and provide comfortable service conditions. The analysis of the experience of libraries in the creation and use of multimedia products allows the identification of main trends in the use of multimedia in library practice, studying the range of existing multimedia products, their features, advantages and typical errors. The purpose of the work is to study the foreign experience of creating and using multimedia products in servicing library users. In the course of the research, the following methods were used: analysis of the document flow based on the study of foreign professional periodicals, analysis of the websites of foreign national libraries, comparative analysis of foreign and domestic experience in presenting multimedia products on library websites. Foreign experience is considered on the basis of publications presented in foreign professional periodicals and analysis of multimedia sites of foreign national libraries. Multimedia products of domestic libraries are considered based on the analysis of the assortment presented on the websites of libraries of various levels and departmental affiliation. The description of the features of the implementation of multimedia products and their specific assortment is given. The analysis of publication activity on the problem under consideration and the thematic distribution of publications are presented, foreign journals with the largest number of articles on the research topic are identified. It is established that the issues of creating and using multimedia products are relevant not only for domestic, but also for foreign library practice. The interest of foreign authors in providing services in a remote format is noted. The creation and use of multimedia products in publications is mainly presented by the example of describing the experience of national libraries and libraries of educational institutions. The paper analyzes in detail the range and features of the implementation of multimedia products on the websites of foreign libraries in comparison with domestic library practice. The common types of multimedia products presented by foreign libraries and their difference from similar domestic ones are revealed. The forms of information presentation and additional features implemented in multimedia products are considered. It can be noted that the websites of foreign libraries do not reveal unique multimedia products that are not typical for domestic library practice, at the same time, a number of features in the presentation of information and the species assortment are noted.
The Public Library of P. I. Makushin in Tomsk: The Quantitative and Qualitative Fund Structure at the End of the XIX – the Beginning of the XX Century
Authors: Timofeeva Ju. V.
Published: July 2022

The fund of the Public Library of P. I. Makushin in Tomsk and the dynamics of its replenishment at the end of the XIXth – the beginning of the XXth century are presented and analyzed. The purpose of the article is to reconstruct the fund of this library. To achieve it, use was made of eleven printed catalogs of this library, additions and attachments to them of different years. This base allowed the calculation the number of titles and volumes of books in the library as a whole and in its departments. It is discovered that their number has increased respectively from 3925 and 6415 in 1878 to 7162 and 9334 in 1907, and in 1916 the fund was replenished by another 2753 and 3745 tytles, which allows us to talk about the steady positive dynamics of the fund replenishment. Quantitative indicators of titles and volumes with works by famous domestic and foreign writers are given in dynamics. Short lists of authors whose works on art, scientific and philosophical works presented in the library fund, and a number of works in all departments are compiled. The presence in the fund of such publications that have introduced to readers the achievements of science and technology, various religious, socio-­political and economic teachings, including revolutionary ones, together with the increase in the number of books in the fund and the predominance of secular literature in it is the manifestation of the modernization of traditional society that took place in the country during the period under review.
Revisiting the Detection of Lateral Movement through Sysmon
Authors: Smiliotopoulos Christos , Barbatsalou Konstantia , Kambourakis Georgios
Published: July 2022

This work attempts to answer in a clear way the following key questions regarding the optimal initialization of the Sysmon tool, towards the identification of Lateral Movement in the MS Windows ecosystem. First, from an expert’s standpoint and with reference to the relevant literature, what are the criteria of determining the possibly optimal initialization features of the Sysmon’s event monitoring tool, which are also applicable as custom rules within the config.xml configuration file? Second, based on the identified features, how can a functional configuration file, able to identify as many LM variants as possible, be generated? To answer these questions, we relied on the MITRE ATT&CK knowledge base of adversary tactics and techniques, and focused on the execution of the nine commonest LM methods. The conducted experiments, performed on a properly configured testbed, suggested a great number of interrelated networking features, that were implemented as custom rules in the Sysmon’s config.xml file. Moreover, by capitalizing on the rich corpus of the 870K Sysmon logs collected, we create and evaluate in terms of TP and FP rates an extensible Python .evtx file analyzer, dubbed PeX, which can be used towards automatizing the parsing and scrutiny of such voluminous files. Both the .evtx logs dataset and the developed PeX tool are provided publicly for further propelling future research in this interesting and rapidly evolving field.
Thin-Film Coating Methods: A Successful Marriage of High-Quality and Cost-Effectiveness- A Brief Exploration
Authors: Butt M. A.
Published: July 2022

In this review, several cost-effective thin-film coating methods which include dip-coating, spin-coating, spray-coating, blade-coating, and roll-coating are presented. Each method has its set of advantages and disadvantages depending on the type of application. Not all of them are appropriate for large-scale production due to their certain limitations. That is why the coating method should be selected based on the type and size of substrate including the resolution of the required thin-films. The sol-gel method offers several benefits, such as simplicity in fabrication, excellent film uniformity, the capacity to cover surfaces of any size and over vast areas, and a low processing temperature. Nevertheless, these coating methods are somewhat economical and well managed in low-budget laboratories. Moreover, the produced thin-films are homogeneous and have low-surface roughness. Furthermore, some other thin-film deposition methods such as physical vapor deposition (PVD) and chemical vapor deposition (CVD) are also discussed. Since CVD is not restricted to line-of-sight deposition, a characteristic shared by sputtering, evaporation, and other PVD processes, many manufacturing methods favor it. However, these techniques require sophisticated equipment and cleanroom facility. We aim to provide the pros and cons of thin-film coating methods and let the readers decide the suitable technique for their specific application.
The Plasma Membrane as the Arena for Receptor-Receptor Crosstalk
Authors: Vallés Ana Sofía , Barrantes Francisco J.
Published: July 2022

Fifty years on from the classical fluid-mosaic model of Singer and Nicolson, current views of the plasma membrane portray a much more complex view of this interface region. Compartmentalization, together with transbilayer and lateral asymmetries, provide the structural foundation for functional specializations at the cell surface, including the active role of the lipid microenvironment in the modulation of membrane-bound proteins. The chemical synapse, the site where neurotransmitter-coded signals are decoded by neurotransmitter receptors, adds another layer of complexity to the plasma membrane architectural intricacy, mainly due to the need to accommodate a sizeable number of molecules in a minute subcellular compartment with dimensions barely reaching the micrometer. In this review, we discuss how Nature has developed suitable adjustments to accommodate different types of membrane-bound receptors and scaffolding proteins via membrane microdomains, and how this “efford-sharing” mechanism has evolved to optimize crosstalk or separation or coupling where/when appropriate. To this end, we use a fast ligand-gated neurotransmitter receptor, the nicotinic acetylcholine receptor, and a second-messenger G-protein coupled receptor, the cannabinoid receptor, as paradigmatic example.
Impact of Riverbank Erosion on Rural Food Security in Bangladesh
Authors: Billah Md Masum , Majumdar Abahan , Rahman Syed Mohammad Aminur , Hossain Md Jamal , Talukder Joynulalam
Published: July 2022

Bangladesh is located in the alluvial floodplain of the Ganges–Brahmaputra–Meghna (GMB) river system and its numerous tributaries. In this country, the frequency, as well as severity, of riverbank erosion is high. To examine the impacts of riverbank erosion on rural food security, a baseline survey was conducted in Zajira, Bangladesh. The findings show that most people in the study area are affected by riverbank erosion. Moreover, agricultural production is gradually decreasing as a result of loss of farmland due to the catastrophe and its impacts. In some cases, people lose their entire homestead and are left with few income opportunities and low purchasing power. Consequently, they face the constant threat of a food crisis. The affected people follow some coping mechanisms to face these stressful situations, such as relying on less expensive or less preferred food items. While the local-government authorities have implemented some programmes to assist them, such as food aid and social-safety-net schemes, these are insufficient, due to the government's limited institutional resources and capacities. These findings suggest that for formulating effective rural-development plans, assessing the impact of riverbank erosion on the food security of people living in the affected areas is a prerequisite.
Comparing Gender Diversity in the Process of Higher Education Expansion among Japan, Korea, Taiwan, and the UK for SDG4-Education 2030
Authors: Chang Dian-Fu , Chou Wen-Ching , Chen Tien-Li
Published: July 2022

Ensuring equal access to affordable higher education for women and men has become a crucial target of UNESCO’s SDG4-Education 2030. Currently, about one-third of the world's college-age population participates in higher education, while the gender disparity persists in various systems. This study employed GDP per capita, gross enrollment ratio (GER), and the gender parity index (GPI) to demonstrate how the education systems have expanded resulting in the transformation of gender parity. We selected Japan, Korea, Taiwan, and the UK as research targets using a cross-correlation function and trend analysis to detect concurrent relationships and future trends with GDP per capita, GER, and GPI. The findings suggest Japan, Korea, and the UK continue to show gender disparity and need to respond to this issue in their policy intervention for SDG4-Education 2030. The results reveal a potential problem in the UK when GPI growth might become unlimited with females dominated. This study suggests the higher education expansion phenomenon and gender diversity in mass and universal systems can be detected by the trend analysis with GDP per capita, GER, and GPI in different settings. The design of the study provides an example to explore the gender diversity patterns in higher education systems for sustainable development.
Water: Social Responsibility and the Concept of Common Good in the Ancient City of Pompeii
Authors: Rossi Adriana , Gonizzi Barsanti Sara
Published: July 2022

Pompeii was connected to the great Serino aqueduct under the principate of Augustus. From that moment on, water became not only a precious resource for the inhabitants but also their true social indicator. It is no coincidence, in fact, that the concentration of sumptuous dwellings is in Regio VI, the district closest to the aqueduct reservoir (castellum aquae in Latin) and the one most equipped with piezometric towers, the first of the network, the ones that would never leave the decorative fountains of the peristyles dry. From this observation follows the original possibility of considering the water network a factor that contributed to designating the morphology of urban neighbourhoods and blocks.
Genetic Sequence Variation in the Plasmodium falciparum Histidine-rich Protein 2 Gene from Field Isolates in Tanzania: Impact on Malaria Rapid Diagnosis
Authors: Kaaya Robert D. , Amour Caroline , Matowo Johnson , Mosha Franklin , Kavishe Reginald Adolf , Beshir Khalid B.
Published: July 2022

Malaria rapid diagnosis test (RDT) is crucial for managing the disease, and the effectiveness of detection depends on parameters such as sensitivity and specificity of the RDT. Several factors can affect the performance of RDT. In this study, we focus on pfhrp2 sequence variation and its impact on RDTs targeted by antigens encoded by pfhrp2. Field samples collected during cross-sectional surveys in Tanzania were sequenced to investigate pfhrp2 sequence diversity and evaluate the impact on HRP2-based RDT performance. We observed significant mean differences in amino acid repeats between current and previous studies. Several new amino acid repeats were found to occur at different frequencies, including types AAY, AHHAHHAAN and AHHAA. Based on the abundance of types 2 and 7 amino acid repeats, the binary predictive model was able to predict RDT insensitivity by about 69 % in the study area. About 85% of the major epitopes targeted by Monoclonal antibodies (MAbs) in RDT were identified. Our study suggests that the extensive sequence variation in the pfhrp2 could contribute to reduced RDT sensitivity. The correlation between the different combinations of amino acid repeats and the performance of RDT in different malaria transmission settings should be investigated further.
Evaluasi dan Arahan Peningkatan Pelayanan Air Bersih di Kota Makassar
Authors: Toding Arthur , Arifin Mimi , Sutopo Yashinta Kumala Dewi
Published: July 2022

Clean water services are still a problem faced by the Makassar City government, South Sulawesi. The high demand for clean water services is currently not being handled properly. The aim of this research is to determine the factors that affect clean water services and the problems. This research was conducted from April 2019 to January 2020 (10 months). This research used primary and secondary data. The analysis used in this research is descriptive analysis with qualitative and quantitative approaches and spatial analysis through mapping using the ArcMap application. The results showed that the factors affecting clean water services in Makassar City are clean water sources, production capacity, location, number of people served, climate, water loss (leakage), water treatment management, and financing. Problems experienced by the community in clean water services in Makassar City are leaks, not running water, checking bills, problematic meters, dirty and smelly water, broken pipes, problematic payments and others (new installation and moving meters). To fulfill the need for clean water in Makassar City, can be added with additional water sources which are processed and distributed to the community, by using water from rivers around Makassar City and utilizing rain water harvesting or seawater desalination. In addition, it is necessary to improve the clean water distribution system and water treatment management from the source to the distribution of water to the community to reduce the level of water loss.
Healthy Davis Together: Creating a Model for Community Control of COVID-19
Authors: Pollock Brad H. , Bergheimer Charlotte L. , Nesbitt Thomas S. , Stoltz Tod , Belafsky Sheri R. , Burtis Kenneth C. , Carey Kelly M. , Nuño Miriam
Published: July 2022

While many higher-education institutions dramatically altered their operations and helped mitigate COVID-19 transmission on campuses, these efforts were rarely fully extended to surrounding communities. A community pandemic-response program was launched in a college town that deployed epidemiological infection-control measures and health behavior change interventions. An increase in self-reported preventive health behaviors and a lower relative case positivity proportion were observed. The program identified scalable approaches that may generalize to other college towns and community types. Building public health infrastructure with such programs may be pivotal in promoting health in the postpandemic era. (Am J Public Health. 2022;112(8):1142–1146. https://doi.org/10.2105/AJPH.2022.306880 )
The Missing COVID-19 Demographic Data: A Statewide Analysis of COVID-19–Related Demographic Data From Local Government Sources and a Comparison With Federal Public Surveillance Data
Authors: Aliseda-Alonso Angel , Lis Sara Bertran de , Lee Adam , Pond Emily N. , Blauer Beth , Rutkow Lainie , Nuzzo Jennifer B.
Published: July 2022

Objectives. To collect and standardize COVID-19 demographic data published by local public-facing Web sites and analyze how this information differs from Centers for Disease Control and Prevention (CDC) public surveillance data.

Methods. We aggregated and standardized COVID-19 data on cases and deaths by age, gender, race, and ethnicity from US state and territorial governmental sources between May 24 and June 4, 2021. We describe the standardization process and compare it with the CDC’s process for public surveillance data.

Results. As of June 2021, the CDC’s public demographic data set included 80.9% of total cases and 46.7% of total deaths reported by states, with significant variation across jurisdictions. Relative to state and territorial data sources, the CDC consistently underreports cases and deaths among African American and Hispanic or Latino individuals and overreports deaths among people older than 65 years and White individuals.

Conclusions. Differences exist in amounts of data included and demographic composition between the CDC’s public surveillance data and state and territory reporting, with large heterogeneity across jurisdictions. A lack of standardization and reporting mechanisms limits the production of complete real-time demographic data.
Gas Reservoir Engineering
Authors: Lee John , Wattenbargar Robert A.
Published: July 2022

Gas Reservoir Engineering provides the undergraduate as well as the graduate student with an introduction to fundamental problem solving in gas reservoir engineering through practical equations and methods. Although much oil well technology applies to gas wells, many differences exist. This book helps students understand and recognize these differences to enable appropriate handling of gas reservoir problems.
Applied Geostatistics for Reservoir Characterization
Authors: Kelkar Mohan , Perez Godofredo
Published: July 2022

Geostatistics is an increasingly important tool for developing an integrated reservoir description. Though Applied Geostatistics for Reservoir Characterization is written to illustrate the importance of geostatistics in improving the reservoir characterization process, it does not require any prior knowledge of statistics or advanced mathematics. Emphasis is placed on intuitive understanding of procedure rather than on mathematical details. Each chapter has an associated appendix in which additional mathematical details are provided. Several numerical and field examples, as well as a large number of illustrations, are provided to explain the strengths and weaknesses of different methods.
Practical Aspects of CO2 Flooding
Authors: Jarrell Perry M. , Fox Charles E. , Stein Michael H. , Webb Steven L.
Published: July 2022

Practical Aspects of CO2 Flooding serves as a logical guide to the practicing engineer focused on the “how to” and “why” of miscible and immiscible CO2 flooding. The book outlines the entire project development sequence from conception and justification through field design and operation. Discussion centers on current and practical CO2 flooding technologies and industry experiences, and it targets those involved in planning, designing, and implementing CO2 floods. The book has five appendices including a compendium of practical, field-specific publications.
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes
Authors: Shoham Ovadia
Published: July 2022

The objectives of this book are twofold: to provide insight and understanding of two-phase flow phenomena and to develop analytical tools for either designing two-phase flow systems or conducting research in this area. The traditional approach for two-phase flow prediction was based on the development of an empirical correlation from experimental data. This book presents the recent approach, in which mathematical mechanistic models are developed, based on the physical phenomena, to predict two-phase flow behavior. The models can be verified and refined with limited experimental data. However, as these models incorporate the physical phenomena and the important flow variables, they can be extended to different operational conditions and can enable scaleup with significant confidence.
Fundamentals of Drilling Engineering
Authors: Mitchell Robert F. , Miska Stefan Z.
Published: July 2022

Fundamentals of Drilling Engineering, an update of the classic Applied Drilling Engineering (Textbook Series Vol. 2), takes a new look at the basics of drilling engineering. Chapters are written by experts from industry and academia and provide numerous example problems to reinforce the concepts presented. This book is essential for undergraduate and graduate students, as well as industry professionals trying to gain detailed knowledge of basic drilling concepts.
Chemistry for Enhancing the Production of Oil and Gas
Authors: Frenier Wayne W. , Ziauddin Murtaza
Published: July 2022

Providing an overview of the science and technology of the use of production chemicals to enhance and maintain oil and gas production, Chemistry for Enhancing the Production of Oil and Gas is geared towards a technically trained audience. Readers will find a review of the important chemical and physical principles that are common to most, if not all, of the enhancement treatments. The authors also discuss aspects of the use and mechanisms of the complex chemistries that take place with the application of flow assurance chemicals, during stimulation (reactive chemistry and prop fracturing) and chemically improved oil recovery, including the use of chemical tracers. A final chapter emphasizes the importance of health, safety, and environmental compliance in all aspects of oilfield treatments. Most of the chapters found within end with a section where successful chemical enhancement or control methods have been used to solve specific production problems.
Acid Stimulation
Authors: Ali Syed A. , Kalfayan Leonard , Montgomery Carl T.
Published: July 2022

Stimulation of oil, gas, and injection wells with acid is almost as old as the petroleum engineering industry itself. Acid Stimulation, ensures a comprehensive and up-to-the-minute presentation by 19 subject matter experts, all at the forefront of the development of acidizing technology. Each chapter delivers an authoritative presentation of the key areas of Acid Stimulation, providing an important resource for anyone who designs, analyzes, and/or improves acidizing treatments.

Acid Stimulation includesA concise review of the tremendous amount of information that has been gathered on the subject since the introduction of the first patents 100 years ago.A summary of the mechanisms that cause formation damage and how to quantify that damage.A summary of the chemistry, reaction kinetics, and methods of measurement of reactive fluids.The latest design information and philosophies for both carbonate and sandstone acidizing.Coverage of diversion, acid additives, and acid corrosion control included.Includes guidelines for treatment evaluation and real-time diagnostics.The latest models and measurement techniques for the prediction of acid fracture conductivity, rock dissolution, worm-holing fluid loss, and acid transport.Current practices in acid treatment safety, quality control, and protection of the environment.Many of the sections are supplemented with problem sets to reinforce concepts.