DESIGN AND ANALYSIS OF CISSUS QUADRANGULARIS L. BY DESIGN OF EXPERIMENTS AS A NOVEL HERBAL GEL
Authors:   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Sundar Roy Gouranga , Das Sarkar Raktimava ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Bose Aryama ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Mondal Adrika ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Singh Amrik ,   Pharmacy Officer at Government Hospital, Lopon, Dist- Moga, Punjab- 142037., Midya Moumita ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Goswami Rajdip ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Singha Moumita ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Maity Priyankar ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Debnath Sushreya ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Maiti Siddheswar ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Banerjee Sangita ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102., Majumder Raja ,   Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal - 712102.
Published: October 2023

Cissus quadrangularis has a common Bengali name as HARJORA has the property of BONE-HEALING. Using DESIGN OF EXPERIMENTS, it was formulated a novel Gel with Propylene Glycol and Carbopol 940 as Independent-Variable and Viscosity, Spreadibility Factor and Endurability as Dependable-Variable. Thus, a Factorial Design by DOE as 3 to the power 2, or 32 or 9 nine Formulations. An optimum formulation was obtained as F-1 from a series of F-1 to F-9. Out of these nine formulations tested for Quality Control F-1 depicts the gem of nine. In case of a crack or fracture F-1 can be used to heal the bone by applying locally. In DOE factorial design, -1,0, & +1 Level for Propylene Glycol [PG] and Carbopol 940 were taken for experimentation purpose. With 1:1 EtOH:H2O as a solvent, the green CQ Plant modified stem was dissolved 3 times of the macerant. After filtration and centrifugation the dose was adjusted in 5ml of the extract. An elaborate study by varying the ingredients formulations were prepared. These formulations were undergone analysis by Macro-Physico established protocols. Viscosity, Spreadibility, Extrudability, Conductivity and pH homogeneity were among the parameters. In future, stability indicating protocols to be developed that will assure the shelf-life of this Harjora-Herbal-Gel.