bluuebunny/crossref_metadata_2025 huggingface dataset:
Automaticity and Executive Abilities in Developmental Dyslexia: A Theoretical Review
Authors: Smith-Spark James H. , Gordon Rebecca
Published: March 2022

Cognitive difficulties are well documented in developmental dyslexia but they present a challenge to dyslexia theory. In this paper, the Model of the Control of Action is proposed as a theoretical explanation of how and why deficits in both automaticity and executive abilities are apparent in the cognitive profiles of dyslexia and how these deficits might relate to literacy difficulties. This theoretical perspective is used to consider evidence from different cognitive domains. The neuroanatomical underpinnings of automaticity and executive abilities are then discussed in relation to the understanding of dyslexia. Links between reading, writing, and executive function are considered. The reviewed evidence suggests that dyslexia theory should consider an interaction between procedural learned behaviour (automaticity) and higher-order (executive) abilities. The capacity to handle environmental interference, develop and engage adaptive strategies accordingly, and plan actions all require interactions between the cerebellum and the prefrontal cortex (PFC). Difficulties in these areas might explain both impairments in the cumulative development of literacy skills in childhood and general task management in everyday life in adulthood. It is suggested that improved measures are required to assess this cerebellar–PFC interaction and to allow early identification of future literacy difficulties, allowing implementation of timely interventions and reasonable adjustments.
The Neural Responses of Visual Complexity in the Oddball Paradigm: An ERP Study
Authors: Hu Rui , Zhang Liqun , Meng Pu , Meng Xin , Weng Minghan
Published: March 2022

This research measured human neural responses to images of different visual complexity levels using the oddball paradigm to explore the neurocognitive responses of complexity perception in visual processing. In the task, 24 participants (12 females) were required to react to images with high complexity for all stimuli. We hypothesized that high-complexity stimuli would induce early visual and attentional processing effects and may elicit the visual mismatch negativity responses and the emergence of error-related negativity. Our results showed that the amplitude of P1 and N1 were unaffected by complexity in the early visual processing. Under the target stimuli, both N2 and P3b components were reported, suggesting that the N2 component was sensitive to the complexity deviation, and the attentional processing related to complexity may be derived from the occipital zone according to the feature of the P3b component. In addition, compared with the low-complexity stimulus, the high-complexity stimulus aroused a larger amplitude of the visual mismatch negativity. The detected error negativity (Ne) component reflected the error detection of the participants’ mismatch between visual complexity and psychological expectations.
A Proposed Model of Assessing the Adaptive Reuse of Heritage Buildings in Historic Jeddah
Authors: Alhojaly Rawan Abdullatif , Alawad Abeer Abdulaziz , Ghabra Noura Abdulrahman
Published: March 2022

Because of the remarkable interest in preserving the architectural heritage of the Kingdom of Saudi Arabia and the emergence of multiple models of adaptively reused heritage buildings in the historic Jeddah area, it is necessary to ensure their correct usage, periodic evaluation, and sustainability. This study develops a model for evaluating the adaptive reuse of historical buildings to preserve their integrity and originality. It adopts a qualitative approach and analyzes references and charters, as well as classifications and methodologies associated with the adaptive use of heritage buildings. The model consists of two main axes. The first includes the basic information on the building, and the second includes elements and criteria for reuse, restoration, and repair, as well as intangible elements of the cultural heritage that can improve people’s livelihoods. It was judged by five architectural heritage specialists in the region to ensure comprehensiveness. This study will draw the attention of those responsible for preserving heritage buildings toward the need for the periodic evaluation of buildings, which can be done through use of the model, to ensure the authenticity and sustainability of historical buildings during reuse and determine if activities should continue or be halted.
Palliation in Gallbladder Cancer: The Role of Gastrointestinal Endoscopy
Authors: Schepis Tommaso , Boškoski Ivo , Tringali Andrea , Bove Vincenzo , Costamagna Guido
Published: March 2022

Gallbladder cancer is a rare malignancy burdened by poor prognosis with an estimated 5-year survival of 5% to 13% due to late presentation, early infiltration of surrounding tissues, and lack of successful treatments. The only curative approach is surgery; however, more than 50% of cases are unresectable at the time of diagnosis. Endoscopy represents, together with surgery and chemotherapy, an available palliative option in advanced gallbladder cancers not eligible for curative treatments. Cholangitis, jaundice, gastric outlet obstruction, and pain are common complications of advanced gallbladder cancer that may need endoscopic management in order to improve the overall survival and the patients’ quality of life. Endoscopic biliary drainage is frequently performed to manage cholangitis and jaundice. ERCP is generally the preferred technique allowing the placement of a plastic stent or a self-expandable metal stent depending on the singular clinical case. EUS-guided biliary drainage is an available alternative for patients not amenable to ERCP drainage (e.g., altered anatomy). Gastric outlet obstruction is another rare complication of gallbladder malignancy growing in contact with the duodenal wall and causing its compression. Endoscopy is a less invasive alternative to surgery, offering different options such as an intraluminal self-expandable metal stent or EUS-guided gastroenteroanastomosis. Abdominal pain associated with cancer progression is generally managed with medical treatments; however, for incoercible pain, EUS-guided celiac plexus neurolysis has been described as an effective and safe treatment. Locoregional treatments, such as radiofrequency ablation (RFA), photodynamic therapy (PDT), and intraluminal brachytherapy (IBT), have been described in the control of disease progression; however, their role in daily clinical practice has not been established yet. The aim of this study is to perform a review of the literature in order to assess the role of endoscopy and the available techniques in the palliative therapy of advanced gallbladder malignancy.
Refining AML Treatment: The Role of Genetics in Response and Resistance Evaluation to New Agents
Authors: Halik Adriane , Arends Christopher Maximilian , Bullinger Lars , Damm Frederik , Frick Mareike
Published: March 2022

The number of treatment options for acute myeloid leukemia (AML) has greatly increased since 2017. This development is paralleled by the broad implantation of genetic profiling as an integral part of clinical studies, enabling us to characterize mutation–response, mutation–non-response, or mutation–relapse patterns. The aim of this review is to provide a concise overview of the current state of knowledge with respect to newly approved AML treatment options and the association of response, relapse and resistance with genetic alterations. Specifically, we will highlight current genetic data regarding FLT3 inhibitors, IDH inhibitors, hypomethylating agents (HMA), the BCL-2 inhibitor venetoclax (VEN), the anti-CD33 antibody conjugate gemtuzumab ozogamicin (GO) and the liposomal dual drug CPX-351.
A Multidisciplinary Approach to Complex Dermal Sarcomas Ensures an Optimal Clinical Outcome
Authors: Trøstrup Hannah , Bigdeli Amir K. , Krogerus Christina , Kneser Ulrich , Schmidt Grethe , Schmidt Volker J.
Published: March 2022

Primary dermal sarcomas (PDS) belong to a highly clinically, genetically and pathologically heterogeneous group of rare malignant mesenchymal tumours primarily involving the dermis or the subcutaneous tissue. The tumours are classified according to the mesenchymal tissue from which they originate: dermal connective tissue, smooth muscle or vessels. Clinically, PDS may mimic benign soft tissue lesions such as dermatofibromas, hypertrophic scarring, etc. This may cause substantial diagnostic delay. As a group, PDS most commonly comprises the following clinicopathological forms of dermal sarcomas: dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX), dermal undifferentiated pleomorphic sarcoma (DUPS), leiomyosarcoma (LMS), and vascular sarcomas (Kaposi’s sarcoma, primary angiosarcoma, and radiation-induced angiosarcoma). This clinical entity has a broad spectrum regarding malignant potential; however, local aggressive behaviour in some forms causes surgical challenges. Preoperative, individualised surgical planning with complete free margins is pivotal along with a multidisciplinary approach and collaboration across highly specialised surgical and medical specialties. The present review gives a structured overview of the most common forms of dermal sarcomas including surgical recommendations and examples for advanced reconstructions as well as the current adjunctive medical treatment strategies. Optimal aesthetic and functional outcomes with low recurrence rates can be achieved by using a multidisciplinary approach to complex dermal sarcomas. In cases of extended local tumour invasion in dermal sarcomas, advanced reconstructive techniques can be applied, and the interdisciplinary microsurgeon should be an integral part of the sarcoma board.
TIA1 Loss Exacerbates Fatty Liver Disease but Exerts a Dual Role in Hepatocarcinogenesis
Authors: Dolicka Dobrochna , Zahoran Szabolcs , Correia de Sousa Marta , Gjorgjieva Monika , Sempoux Christine , Fournier Margot , Maeder Christine , Collart Martine A. , Foti Michelangelo , Sobolewski Cyril
Published: March 2022

Alterations in specific RNA-binding protein expression/activity importantly contribute to the development of fatty liver disease (FLD) and hepatocellular carcinoma (HCC). In particular, adenylate–uridylate-rich element binding proteins (AUBPs) were reported to control the post-transcriptional regulation of genes involved in both metabolic and cancerous processes. Herein, we investigated the pathophysiological functions of the AUBP, T-cell-restricted intracellular antigen-1 (TIA1) in the development of FLD and HCC. Analysis of TIA1 expression in mouse and human models of FLD and HCC indicated that TIA1 is downregulated in human HCC. In vivo silencing of TIA1 using AAV8-delivered shRNAs in mice worsens hepatic steatosis and fibrosis induced by a methionine and choline-deficient diet and increases the hepatic tumor burden in liver-specific PTEN knockout (LPTENKO) mice. In contrast, our in vitro data indicated that TIA1 expression promoted proliferation and migration in HCC cell lines, thus suggesting a dual and context-dependent role for TIA1 in tumor initiation versus progression. Consistent with a dual function of TIA1 in tumorigenesis, translatome analysis revealed that TIA1 appears to control the expression of both pro- and anti-tumorigenic factors in hepatic cancer cells. This duality of TIA1′s function in hepatocarcinogenesis calls for cautiousness when considering TIA1 as a therapeutic target or biomarker in HCC.
How to Improve SBRT Outcomes in NSCLC: From Pre-Clinical Modeling to Successful Clinical Translation
Authors: Milic Marina , Mondini Michele , Deutsch Eric
Published: March 2022

Despite major research and clinical efforts, lung cancer remains the leading cause of cancer-related death. While the delivery of conformal radiotherapy and image guidance of stereotactic body radiotherapy (SBRT) have revolutionized the treatment of early-stage non-small-cell lung cancer (NSCLC), additional research is needed to elucidate underlying mechanisms of resistance and identify novel therapeutic combinations. Clinical progress relies on the successful translation of pre-clinical work, which so far has not always yielded expected results. Improved clinical modelling involves characterizing the preclinical models and selecting appropriate experimental designs that faithfully mimic precise clinical scenarios. Here, we review the current role of SBRT and the scope of pre-clinical armamentarium at our disposal to improve successful clinical translation of pre-clinical research in the radiation oncology of NSCLC.
Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins
Authors: Yamamoto Masahiro , Suzuki Shuhei , Togashi Keita , Sugai Asuka , Okada Masashi , Kitanaka Chifumi
Published: March 2022

Despite several clinical trials with encouraging findings, effective standard systemic therapies have yet to be established for malignant meningioma and the prognosis of these patients remains poor. Accumulating preclinical and clinical evidence suggests that gemcitabine is effective against malignant meningioma. To identify drugs with therapeutic effects that may be enhanced in combination with gemcitabine, we screened drugs that have been tested in preclinical and clinical trials for meningioma. In IOMM-Lee and HKBMM malignant meningioma cells, gemcitabine enhanced the growth inhibitory effects of the mTOR inhibitor everolimus, the clinical benefits of which have been demonstrated in patients with meningioma. The synergistic growth inhibitory effects of this combination were accompanied by cellular senescence characterized by an increase in senescence-associated β-galactosidase activity. To enhance the effects of this combination, we screened senolytic drugs that selectively kill senescent cells, and found that navitoclax, an inhibitor of anti-apoptotic BCL-2 family proteins, effectively reduced the number of viable malignant meningioma cells in combination with everolimus and gemcitabine by inducing apoptotic cell death. The suppression of tumor growth in vivo by the combination of everolimus with gemcitabine was significantly stronger than that by either treatment alone. Moreover, navitoclax, in combination with everolimus and gemcitabine, significantly reduced tumor sizes with an increase in the number of cleaved caspase-3-positive apoptotic cells. The present results suggest that the addition of gemcitabine with or without navitoclax to everolimus is a promising strategy that warrants further evaluation in future clinical trials for malignant meningioma.
Fabrication of High-Performance Asymmetric Supercapacitor Consists of Nickel Oxide and Activated Carbon (NiO//AC)
Authors: Vinodh Rajangam , Babu Rajendran Suresh , Atchudan Raji , Kim Hee-Je , Yi Moonsuk , Samyn Leandro Marques , de Barros Ana Lucia Ferreira
Published: March 2022

Exploring faster, safer, and more efficient energy storage devices will motivate scientists to develop novel energy storage products with high performance. Herein, we report porous NiO nanoparticles have been prepared by a simple hydrothermal method with CTAB and laboratory tissue paper as a template followed by calcination at three different temperatures (300, 500, and 700 °C). The electrochemical characteristics of the prepared materials were examined in a three-electrode cell configuration using aqueous potassium hydroxide (2.0 M KOH) electrolyte. The NiO-300 electrode displayed the supreme capacitance of 568.7 F g−1 at 0.5 A g−1. The fascinating NiO morphology demonstrates a crucial part in offering simple ion transport, shortening electron, and ion passage channels and rich energetic spots for electrochemical reactions. Finally, the asymmetric supercapacitor (ASC), NiO//AC was constructed using positive and negative electrode materials of NiO-300 and activated carbon (AC), respectively. The assembled ASC displayed excellent supercapacitive performance with a high specific energy (52.4 Wh kg−1), specific power (800 W kg−1), and remarkable cycle life. After quick charging (25 s), such supercapacitors in the series will illuminate the light emitting diode for an extended time, suggesting improvements in energy storage, scalable integrated applications, and ensuring business efficacy. This work will lead to a new generation of high-performance ASCs to portable electronic displays and electric automobiles.
FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells
Authors: Zhong Qian , Liu Yixin , Correa Michele Ramos , Marconett Crystal Nicole , Minoo Parviz , Li Changgong , Ann David K. , Zhou Beiyun , Borok Zea
Published: March 2022

NKX2.1 is a master regulator of lung morphogenesis and cell specification; however, interactions of NKX2.1 with various transcription factors to regulate cell-specific gene expression and cell fate in the distal lung remain incompletely understood. FOXO1 is a key regulator of stem/progenitor cell maintenance/differentiation in several tissues but its role in the regulation of lung alveolar epithelial progenitor homeostasis has not been evaluated. We identified a novel role for FOXO1 in alveolar epithelial cell (AEC) differentiation that results in the removal of NKX2.1 from surfactant gene promoters and the subsequent loss of surfactant expression in alveolar epithelial type I-like (AT1-like) cells. We found that the FOXO1 forkhead domain potentiates a loss of surfactant gene expression through an interaction with the NKX2.1 homeodomain, disrupting NKX2.1 binding to the SFTPC promoter. In addition, blocking PI-3K/AKT signaling reduces phosphorylated FOXO-1 (p-FOXO1), allowing accumulated nuclear FOXO1 to interact with NKX2.1 in differentiating AEC. Inhibiting AEC differentiation in vitro with keratinocyte growth factor (KGF) maintained an AT2 cell phenotype through increased PI3K/AKT-mediated FOXO1 phosphorylation, resulting in higher levels of surfactant expression. Together these results indicate that FOXO1 plays a central role in AEC differentiation by directly binding NKX2.1 and suggests an essential role for FOXO1 in mediating AEC homeostasis.
Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery
Authors: Urbanowicz Tomasz , Michalak Michał , Olasińska-Wiśniewska Anna , Rodzki Michał , Witkowska Anna , Gąsecka Aleksandra , Buczkowski Piotr , Perek Bartłomiej , Jemielity Marek
Published: March 2022

Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB). Hematological parameters, whether single or combined as indices, provide higher predictive values. Methods: The study group comprised 538 consecutive patients (125 (23%) females and 413 (77%) males) with a mean age of 65 ± 9 years, who underwent OPCAB with a mean follow-up time of 4.7 ± 1.7 years. This single-center retrospective analysis included perioperative inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), aggregate index of systemic inflammation (AISI), and systemic inflammatory index (SII). Results: Multivariable analysis identified levels of neutrophils above 4.3 × 109/L (HR 13.44, 95% CI 1.05–3.68, p = 0.037), values of SIRI above 5.4 (HR 0.29, 95% CI 0.09–0.92, p = 0.036) and values of NLR above 3.5 (HR 2.21, 95% CI 1.48–3.32, p < 0.001) as being significant predictors of long-term mortality. The multifactorial models revealed the possibility of strong prediction by combining preoperative factors (COPD, stroke, PAD, and preoperative PLR) and postoperative neutrophil counts (p = 0.0136) or NLR (p = 0.0136) or SIRI (p = 0.0136). Conclusions: Among the postoperative inflammatory indices, the levels of neutrophils, NLR, and SIRI are the most prominent markers for long-term survival after off-pump coronary artery bypass surgery, when combined with preoperative characteristics.
Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice
Authors: Liu Jingwei , Hernandez Rebecca , Li Xiuchun , Meng Zhaojie , Chen Hong , Zhou Changcheng
Published: March 2022

Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain elusive. Dicyclohexyl phthalate (DCHP) is a widely used phthalate plasticizer; whether and how exposure to DCHP elicits adverse effects in vivo is mostly unknown. We previously reported that DCHP is a potent ligand of the pregnane X receptor (PXR) which acts as a xenobiotic sensor to regulate xenobiotic metabolism. PXR also functions in macrophages to regulate atherosclerosis development in animal models. In the current study, LDL receptor-deficient mice with myeloid-specific PXR deficiency (PXRΔMyeLDLR−/−) and their control littermates (PXRF/FLDLR−/−) were used to determine the impact of DCHP exposure on macrophage function and atherosclerosis. Chronic exposure to DCHP significantly increased atherosclerotic lesion area in the aortic root and brachiocephalic artery of PXRF/FLDLR−/− mice by 65% and 77%, respectively. By contrast, DCHP did not affect atherosclerosis development in PXRΔMyeLDLR−/− mice. Exposure to DCHP led to elevated expression of the scavenger receptor CD36 in macrophages and increased macrophage form cell formation in PXRF/FLDLR−/− mice. Our findings provide potential mechanisms underlying phthalate-associated CVD risk and will ultimately stimulate further investigations and mitigation of the adverse effects of plastic-associated EDCs on CVD risk in humans.
Single-Cell Molecular Characterization to Partition the Human Glioblastoma Tumor Microenvironment Genetic Background
Authors: Lessi Francesca , Franceschi Sara , Morelli Mariangela , Menicagli Michele , Pasqualetti Francesco , Santonocito Orazio , Gambacciani Carlo , Pieri Francesco , Aquila Filippo , Aretini Paolo , Mazzanti Chiara Maria
Published: March 2022

Background: Glioblastoma (GB) is a devastating primary brain malignancy. The recurrence of GB is inevitable despite the standard treatment of surgery, chemotherapy, and radiation, and the median survival is limited to around 15 months. The barriers to treatment include the complex interactions among the different cellular components inhabiting the tumor microenvironment. The complex heterogeneous nature of GB cells is helped by the local inflammatory tumor microenvironment, which mostly induces tumor aggressiveness and drug resistance. Methods: By using fluorescent multiple labeling and a DEPArray cell separator, we recovered several single cells or groups of single cells from populations of different origins from IDH-WT GB samples. From each GB sample, we collected astrocytes-like (GFAP+), microglia-like (IBA1+), stem-like cells (CD133+), and endothelial-like cells (CD105+) and performed Copy Number Aberration (CNA) analysis with a low sequencing depth. The same tumors were subjected to a bulk CNA analysis. Results: The tumor partition in its single components allowed single-cell molecular subtyping which revealed new aspects of the GB altered genetic background. Conclusions: Nowadays, single-cell approaches are leading to a new understanding of GB physiology and disease. Moreover, single-cell CNAs resource will permit new insights into genome heterogeneity, mutational processes, and clonal evolution in malignant tissues.
ROCK ‘n TOR: An Outlook on Keratinocyte Stem Cell Expansion in Regenerative Medicine via Protein Kinase Inhibition
Authors: Centonze Giorgia , Centonze Sara , Ponzone Luca , Calautti Enzo
Published: March 2022

Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark example of successful cellular therapies by restoring durable integrity in stratified epithelia lost to devastating tissue conditions. Despite the overall success of such procedures, failures still occur in case of paucity of cultured stem cells in therapeutic grafts. Strategies aiming at a further amplification of stem cells during keratinocyte ex vivo expansion may thus extend the applicability of these treatments to subjects in which endogenous stem cells pools are depauperated by aging, trauma, or disease. Pharmacological targeting of stem cell signaling pathways is recently emerging as a powerful strategy for improving stem cell maintenance and/or amplification. Recent experimental data indicate that pharmacological inhibition of two prominent keratinocyte signaling pathways governed by apical mTOR and ROCK protein kinases favor stem cell maintenance and/or amplification ex vivo and may improve the effectiveness of stem cell-based therapeutic procedures. In this review, we highlight the pathophysiological roles of mTOR and ROCK in keratinocyte biology and evaluate existing pre-clinical data on the effects of their inhibition in epithelial stem cell expansion for transplantation purposes.
The Influence of a Finite Control Boundary on the Morphological Evolution of Wandering Channels
Authors: Xu Linjuan , He Na , Li Junhua , Zhang Xiang , Zhao Wanjie
Published: March 2022

Although it is a consensus in academic circles that regulation works will change a channel’s shape, the quantitative relationship between the finite control boundary and the channel’s shape parameters is still unclear. In this study, a flume model test was carried out, and the evolution of channel’s shape under different engineering densities was qualitatively analyzed. Based on the construction of river regulation works and measured hydrological data of the wandering channel in the lower Yellow River from 1960 to 2014, the channel shape parameters (bending coefficient, swing range of the main streamline and river facies coefficient) of the wandering channel in different periods were calculated, and the variation in the channel shape parameters with the density of regulation works in different periods was analyzed. The results showed that the river regime cannot be effectively controlled with less dense regulation works; in this case, the regulation works have little impact on the channel’s morphology. With an increase in the density of regulation works, the evolution of channel morphology was obviously different. Specifically, the river bending coefficient increased as a whole from 1.14 in 1949–1960 to 1.32 in 2011–2014, indicating that the regulation works have had an obvious restraining and improving effect on the river’s morphology. The swing range of the main stream obviously decreased, with an average value of about 500 m; the river facies coefficient decreased dramatically from 20~88 before 1960 to 15 in 2014, and the channel morphology has developed with a tendency to be narrow and deep. The research showed that a finite control boundary can significantly improve the channel’s shape, limit the wandering characteristics of the river reach to a certain extent, stabilize the main stream and control the river’s regime.
Surface Conductivity and Preferred Orientation of TiN Film for Ti Bipolar Plate
Authors: Yan Zhi , Li Tao , Wang Qian , Li Hongjiao , Wang Yao , Wu Chaoling , Yan Yigang , Chen Yungui
Published: March 2022

The properties of thin films are often influenced by the crystal’s preferred orientation. In the present study, we report the strong dependence of surface conductivity on the preferred orientation of TiN film that acts as the coating material for Ti bipolar plate. The preferred orientation of TiN film is successfully controlled along the (111) or (200) planes by adjusting the N2 flow rate or Ti substrate temperature during the deposition process via DC (direct current) reactive magnetron sputtering. Small N2 flow rate of 3 to 6 sccm or low substrate temperature (e.g., 25 °C) facilitates the growth of TiN films along the (111). The (111) preferred orientated TiN films show much lower interfacial contact resistance (ICR) than the (200) preferred orientated films. A considerably low ICR value of 1.9 mΩ·cm2 at 140 N/cm2 is achieved at the N2 flow of 4 sccm and the substrate temperature of 25 °C.
Comparing Nonparametric Estimators for the Number of Shared Species in Two Populations
Authors: Yue Jack C. , Clayton Murray K. , Hung Chi-Ruei
Published: March 2022

It is often of interest to biologists to evaluate whether two populations are alike with respect to a similarity index; assessing the numbers of shared species is one way to do this. In this study, we propose two Turing-type estimators for the probability of discovering new shared species and two jackknife-type estimators for the number of shared species in two populations. We use computer simulation and empirical data analysis to evaluate the proposed approach. The jackknife-type estimators provide stable and reliable estimates, for both the probability of discovering new shared species and the number of shared species. We also compare the jackknife-type estimates with that of using sample coverage to estimate the number of shared species. The estimate of using sample coverage has better performance in the case of even populations, while the jackknife-type estimates have smaller bias in the case of unbalanced populations. When combined with a stopping rule based on the probability of observing new shared species, confidence intervals based on the proposed jackknife-type estimators can provide better coverage probability for the true number of shared species. The jackknife-type estimates can provide coverage probability close to 0.95 in all examples.
Diversity and Distribution of the Inland Water Decapods of Sicily (Crustacea, Malacostraca)
Authors: Vecchioni Luca , Faraone Francesco Paolo , Stoch Fabio , Arculeo Marco , Marrone Federico
Published: March 2022

The current knowledge of Sicilian inland water decapod malacostracans is scarce and an updated synopsis on species distribution is lacking. Therefore, we reviewed the checklist and recent distribution of Sicilian inland water decapods based on published and unpublished records and novel observations with the aim of providing an exhaustive repository, also to be used as a sound baseline for future surveys. Overall, five native decapod species occur in the study area, i.e., the atyid shrimp Atyaephyra desmarestii, the palaemonid shrimps Palaemon adspersus, P. antennarius, and P. elegans, and the freshwater crab Potamon fluviatile, and their current local distributions are described. In addition, three alien species were recorded: the common yabby Cherax destructor and the red swamp crayfish Procambarus clarkii, strictly linked to inland waters, and the Atlantic blue crab Callinectes sapidus, a mainly marine species that can also colonise the lower stretches of rivers and coastal brackish waters. The collected data suggest the existence of a partial segregation of native versus non-native species, with the latter currently confined to coastal water bodies and the lower stretches of rivers. Moreover, the exclusively freshwater caridean A. desmarestii and P. antennarius show a parapatric distribution in the study area, which may suggest the existence of mutual exclusion phenomena. The results obtained raise some concerns about the effects of alien species on the native biota, and dedicated monitoring and management strategies should be implemented in order to better understand and mitigate their impact.
The Plasma Levels of 3-Hydroxybutyrate, Dityrosine, and Other Markers of Oxidative Stress and Energy Metabolism in Major Depressive Disorder
Authors: Krivosova Michaela , Gondas Eduard , Murin Radovan , Dohal Matus , Ondrejka Igor , Tonhajzerova Ingrid , Hutka Peter , Ferencova Nikola , Visnovcova Zuzana , Hrtanek Igor , Mokry Juraj
Published: March 2022

Major depressive disorder (MDD) is a serious mental disease with a pathophysiology that is not yet fully clarified. An increasing number of studies show an association of MDD with energy metabolism alteration and the presence of oxidative stress. We aimed to evaluate plasma levels of 3-hydroxybutyrate (3HB), NADH, myeloperoxidase, and dityrosine (di-Tyr) in adolescent and adult patients with MDD, compare them with healthy age-matched controls, and assess the effect of antidepressant treatment during hospitalisation on these levels. In our study, plasmatic levels of 3HB were elevated in both adolescents (by 55%; p = 0.0004) and adults (by 88%; p < 0.0001) with MDD compared to controls. Levels of dityrosine were increased in MDD adults (by 19%; p = 0.0092) but not adolescents. We have not found any significant effect of antidepressants on the selected parameters during the short observation period. Our study supports the findings suggesting altered energy metabolism in MDD and demonstrates its presence independently of the age of the patients.
Newly Diagnosed Right Coronary Artery Aneurysm in an Adult with Recent Coronavirus Disease 2019 Infection
Authors: Shin Jeong-Hun , Ro Sun Kyun
Published: March 2022

It is well known that coronavirus disease 2019 (COVID-19) can affect the vascular endothelium; however, coronary artery aneurysm complicated by COVID-19 in adults has not yet been reported. Herein, we report a case of a newly developed right coronary artery aneurysm in an adult with recent COVID-19 infection. A 66-year-old man was referred for surgical intervention of the right coronary artery aneurysm. His previous coronary angiograms performed 17 months prior revealed no evidence of coronary aneurysm. However, he was confirmed as having COVID-19 four months prior and thereafter newly diagnosed with right coronary artery aneurysm. The further evaluation of the impact of COVID-19 on the occurrence of coronary artery aneurysm may be necessary, considering the alleged correlation between COVID-19 and vascular complications.
Multi-Contrast MRI Image Synthesis Using Switchable Cycle-Consistent Generative Adversarial Networks
Authors: Zhang Huixian , Li Hailong , Dillman Jonathan R. , Parikh Nehal A. , He Lili
Published: March 2022

Multi-contrast MRI images use different echo and repetition times to highlight different tissues. However, not all desired image contrasts may be available due to scan-time limitations, suboptimal signal-to-noise ratio, and/or image artifacts. Deep learning approaches have brought revolutionary advances in medical image synthesis, enabling the generation of unacquired image contrasts (e.g., T1-weighted MRI images) from available image contrasts (e.g., T2-weighted images). Particularly, CycleGAN is an advanced technique for image synthesis using unpaired images. However, it requires two separate image generators, demanding more training resources and computations. Recently, a switchable CycleGAN has been proposed to address this limitation and successfully implemented using CT images. However, it remains unclear if switchable CycleGAN can be applied to cross-contrast MRI synthesis. In addition, whether switchable CycleGAN is able to outperform original CycleGAN on cross-contrast MRI image synthesis is still an open question. In this paper, we developed a switchable CycleGAN model for image synthesis between multi-contrast brain MRI images using a large set of publicly accessible pediatric structural brain MRI images. We conducted extensive experiments to compare switchable CycleGAN with original CycleGAN both quantitatively and qualitatively. Experimental results demonstrate that switchable CycleGAN is able to outperform CycleGAN model on pediatric MRI brain image synthesis.
Apparent Diffusion Coefficient Map-Based Texture Analysis for the Differentiation of Chromophobe Renal Cell Carcinoma from Renal Oncocytoma
Authors: Uchida Yusuke , Yoshida Soichiro , Arita Yuki , Shimoda Hiroki , Kimura Koichiro , Yamada Ichiro , Tanaka Hajime , Yokoyama Minato , Matsuoka Yoh , Jinzaki Masahiro , Fujii Yasuhisa
Published: March 2022

Preoperative imaging differentiation between ChRCC and RO is difficult with conventional subjective evaluation, and the development of quantitative analysis is a clinical challenge. Forty-nine patients underwent partial or radical nephrectomy preceded by MRI and followed by pathological diagnosis with ChRCC or RO (ChRCC: n = 41, RO: n = 8). The whole-lesion volume of interest was set on apparent diffusion coefficient (ADC) maps of 1.5T-MRI. The importance of selected texture features (TFs) was evaluated, and diagnostic models were created using random forest (RF) analysis. The Mean Decrease Gini as calculated through RF analysis was the highest for mean_ADC_value. ChRCC had a significantly lower mean_ADC_value than RO (1.26 vs. 1.79 × 10−3 mm2/s, p < 0.0001). Feature selection by the Boruta method identified the first-quartile ADC value and GLZLM_HGZE as important features. ROC curve analysis showed that there was no significant difference in the classification performances between the mean_ADC_value-only model and the Boruta model (AUC: 0.954 vs. 0.969, p = 0.236). The mean ADC value had good predictive ability for the distinction between ChRCC and RO, comparable to that of the combination of TFs optimized for the evaluated cohort. The mean ADC value may be useful in distinguishing between ChRCC and RO.
Insights into the Anti-Aging Prevention and Diagnostic Medicine and Healthcare
Authors: Ok Seung-Cheol
Published: March 2022

Aging is an irreversible and natural phenomenon that occurs as a person ages. Anti-aging medicine applies advanced science and medical technology to early detection, prevention, treatment, and reversal of age-related dysfunctions, disorders, and diseases. Therefore, anti-aging diagnostic medicine and healthcare are important factors in helping the elderly population lead healthy and active lives. However, it is challenging to diagnose various aging and related diseases accurately through various forms of anti-aging diagnostic medicine and health management. It may not be treated appropriately, so many older people are making various efforts to prevent aging themselves in advance. Therefore, anti-aging medicine and health care have been developed in various forms, from health checkups to alternative medicine and biophysical technology beyond simple clinical medicine, and are being applied to demand the needs of the elderly. This review intends to explore and characterize various applications related to anti-aging medicine and healthcare in the elderly. In addition, economic, medical, and ethical considerations arising from the relationship between the increase in the elderly population and the continuous development of anti-aging medicine can be considered.
Liver Tumor Localization Based on YOLOv3 and 3D-Semantic Segmentation Using Deep Neural Networks
Authors: Amin Javaria , Anjum Muhammad Almas , Sharif Muhammad , Kadry Seifedine , Nadeem Ahmed , Ahmad Sheikh F.
Published: March 2022

Worldwide, more than 1.5 million deaths are occur due to liver cancer every year. The use of computed tomography (CT) for early detection of liver cancer could save millions of lives per year. There is also an urgent need for a computerized method to interpret, detect and analyze CT scans reliably, easily, and correctly. However, precise segmentation of minute tumors is a difficult task because of variation in the shape, intensity, size, low contrast of the tumor, and the adjacent tissues of the liver. To address these concerns, a model comprised of three parts: synthetic image generation, localization, and segmentation, is proposed. An optimized generative adversarial network (GAN) is utilized for generation of synthetic images. The generated images are localized by using the improved localization model, in which deep features are extracted from pre-trained Resnet-50 models and fed into a YOLOv3 detector as an input. The proposed modified model localizes and classifies the minute liver tumor with 0.99 mean average precision (mAp). The third part is segmentation, in which pre-trained Inceptionresnetv2 employed as a base-Network of Deeplabv3 and subsequently is trained on fine-tuned parameters with annotated ground masks. The experiments reflect that the proposed approach has achieved greater than 95% accuracy in the testing phase and it is proven that, in comparison to the recently published work in this domain, this research has localized and segmented the liver and minute liver tumor with more accuracy.
Disquisitions Relating to Principles of Thermodynamic Equilibrium in Climate Modelling
Authors: Woodcock Leslie V.
Published: March 2022

We revisit the fundamental principles of thermodynamic equilibrium in relation to heat transfer processes within the Earth’s atmosphere. A knowledge of equilibrium states at ambient temperatures (T) and pressures (p) and deviations for these p-T states due to various transport ‘forces’ and flux events give rise to gradients (dT/dz) and (dp/dz) of height z throughout the atmosphere. Fluctuations about these troposphere averages determine weather and climates. Concentric and time-span average values  (z, Δt)) and its gradients known as the lapse rate = d < T(z) >/dz have hitherto been assumed in climate models to be determined by a closed, reversible, and adiabatic expansion process against the constant gravitational force of acceleration (g). Thermodynamics tells us nothing about the process mechanisms, but adiabatic-expansion hypothesis is deemed in climate computer models to be convection rather than conduction or radiation. This prevailing climate modelling hypothesis violates the 2nd law of thermodynamics. This idealized hypothetical process cannot be the causal explanation of the experimentally observed mean lapse rate (approx.−6.5 K/km) in the troposphere. Rather, the troposphere lapse rate is primarily determined by the radiation heat-transfer processes between black-body or IR emissivity and IR and sunlight absorption. When the effect of transducer gases (H2O and CO2) is added to the Earth’s emission radiation balance in a 1D-2level primitive model, a linear lapse rate is obtained. This rigorous result for a perturbing cooling effect of transducer (‘greenhouse’) gases on an otherwise sunlight-transducer gas-free troposphere has profound implications. One corollary is the conclusion that increasing the concentration of an existing weak transducer, i.e., CO2, could only have a net cooling effect, if any, on the concentric average  (z = 0) at sea level and lower troposphere (z < 1 km). A more plausible explanation of global warming is the enthalpy emission ’footprint’ of all fuels, including nuclear.
Practical Security of High-Dimensional Quantum Key Distribution with Intensity Modulator Extinction
Authors: Wang Yang , Du Ge-Hai , Xu Yang-Bin , Zhou Chun , Jiang Mu-Sheng , Li Hong-Wei , Bao Wan-Su
Published: March 2022

Quantum key distribution (QKD) has attracted much attention due to its unconditional security. High-dimensional quantum key distribution (HD-QKD) is a brand-new type of QKD protocol that has many excellent advantages. Nonetheless, practical imperfections in realistic devices that are not considered in the theoretical security proof may have an impact on the practical security of realistic HD-QKD systems. In this paper, we research the influence of a realistic intensity modulator on the practical security of HD-QKD systems with the decoy-state method and finite-key effects. We demonstrate that there is a certain impact in the secret key rate and the transmission distance when taking practical factors into security analysis.
A Survey on Applications of H-Technique: Revisiting Security Analysis of PRP and PRF
Authors: Jha Ashwin , Nandi Mridul
Published: March 2022

The Coefficients H technique (also called the H-technique), developed by Patarin circa 1991, is a tool used to obtain the upper bounds on distinguishing advantages. This tool is known to provide relatively simple and (in some cases) tight bound proofs in comparison to some other well-known tools, such as the game-playing technique and random systems methodology. In this systematization of knowledge (SoK) paper, we aim to provide a brief survey on the H-technique. The SoK is presented in four parts. First, we redevelop the necessary nomenclature and tools required to study the security of any symmetric-key design, especially in the H-technique setting. Second, we provide a full description of the H-technique and some related tools. Third, we present (simple) H-technique-based proofs for some popular symmetric-key designs, across different paradigms. Finally, we show that the H-technique can actually provide optimal bounds on distinguishing advantages.
Fractal Cardioid Slot Antenna for Super Wideband Applications
Authors: Lazović Luka , Jokanovic Branka , Rubežić Vesna , Radovanovic Milos , Jovanović Ana
Published: March 2022

A new geometry for uniplanar, ultra-wideband monopole antenna has been proposed for operations in the 1.8–30 GHz band, thanks to its fractal structure in the form of a cardioid. The antenna has extremely small dimensions at 0.21λ × 0.285λ at the lowest frequency of 1.8 GHz. A parametric analysis of the influence of certain antenna dimensions on its characteristics was performed in order to achieve the widest possible impedance bandwidth. This antenna is designed for low-cost FR-4 substrate because it is primarily intended for use in broadband energy harvesting and IoT systems, but it is also suitable for applications in communication systems. Simulation results show that the antenna has a reflection coefficient (S11) below −10 dB in the entire 1.8 GHz to 30 GHz frequency range, which covers all existing cellular bands: 3G, 4G, 5G Wi-Fi, ISM, satellite communication and radar bands. The antenna exhibits gains up to 5 dBi.
SAGMAD—A Signature Agnostic Malware Detection System Based on Binary Visualisation and Fuzzy Sets
Authors: Saridou Betty , Rose Joseph Ryan , Shiaeles Stavros , Papadopoulos Basil
Published: March 2022

Image conversion of byte-level data, or binary visualisation, is a relevant approach to security applications interested in malicious activity detection. However, in practice, binary visualisation has always been seen to have great limitations when dealing with large volumes of data, and would be a reluctant candidate as the core building block of an intrusion detection system (IDS). This is due to the requirements of computational time when processing the flow of byte data into image format. Machine intelligence solutions based on colour tone variations that are intended for pattern recognition would overtax the process. In this paper, we aim to solve this issue by proposing a fast binary visualisation method that uses Fuzzy Set theory and the H-indexing space filling curve. Our model can assign different colour tones on a byte, allowing it to be influenced by neighbouring byte values while preserving optimal locality indexing. With this work, we wish to establish the first steps in pursuit of a signature-free IDS. For our experiment, we used 5000 malicious and benign files of different sizes. Our methodology was tested on various platforms, including GRNET’s High-Performance Computing services. Further improvements in computation time allowed larger files to convert in roughly 0.5 s on a desktop environment. Its performance was also compared with existing machine learning-based detection applications that used traditional binary visualisation. Despite lack of optimal tuning, SAGMAD was able to achieve 91.94% accuracy, 90.63% precision, 92.7% recall, and an F-score of 91.61% on average when tested within previous binary visualisation applications and following their parameterisation scheme. The results exceeded malware file-based experiments and were similar to network intrusion applications. Overall, the results demonstrated here prove our method to be a promising mechanism for a fast AI-based signature-agnostic IDS.