bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Radiotherapy-Associated Genes in Lung Adenocarcinoma by an Integrated Bioinformatics Analysis Approach
Authors: Wang Junhao , Han Qizheng , Liu Huizi , Luo Haihua , Li Lei , Liu Aihua , Jiang Yong
Published: June 2021

Radiotherapy (RT) plays an important role in the prognosis of lung adenocarcinoma (LUAD) patients, but the radioresistance (RR) of LUAD is still a challenge that needs to be overcome. The current study aimed to investigate LUAD patients with RR to illuminate the underlying mechanisms. We utilized gene set variation analysis (GSVA) and The Cancer Immunome Atlas (TCIA) database to characterize the differences in biological functions and neoantigen-coding genes between RR and radiosensitive (RS) patients. Weighted Gene co-expression network analysis (WGCNA) was used to explore the relationship between RT-related traits and hub genes in two modules, i.e., RR and RS; two representative hub genes for RR (MZB1 and DERL3) and two for RS (IFI35 and PSMD3) were found to be related to different RT-related traits. Further analysis of the hub genes with the Lung Cancer Explorer (LCE), PanglaoDB and GSVA resources revealed the differences in gene expression levels, cell types and potential functions. On this basis, the Tumor and Immune System Interaction Database (TISIDB) was used to identify the potential association between RR genes and B cell infiltration. Finally, we used the Computational Analysis of Resistance (CARE) database to identify specific gene-associated drugs for RR patients and found that GSK525762A and nilotinib might be promising candidates for RR treatment. Taken together, these results demonstrate that B cells in TME may have a significant impact on the RT and that these two drug candidates, GSK525762A and nilotinib, might be helpful for the treatment of RR patients.
Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases
Authors: Suthar Sharad Kumar , Alam Mohammad Maqusood , Lee Jihye , Monga Jitender , Joseph Alex , Lee Sang-Yoon
Published: June 2021

TSPO-associated protein 1 (TSPOAP1) is a cytoplasmic protein and is closely associated with its mitochondrial transmembrane protein partner translocator protein (TSPO). To decipher the canonical signalling pathways of TSPOAP1, its role in human diseases and disorders, and relationship with TSPO; expression analyses of TSPOAP1- and TSPO-associated human genes were performed by Qiagen Ingenuity Pathway Analysis (IPA). In the expression analysis, necroptosis and sirtuin signalling pathways, mitochondrial dysfunction, and inflammasome were the top canonical pathways for both TSPOAP1 and TSPO, confirming the close relationship between these two proteins. A distribution analysis of common proteins in all the canonical pathways predicted for TSPOAP1 revealed that tumor necrosis factor receptor 1 (TNFR1), vascular cell adhesion molecule 1 (VCAM1), cyclic AMP response element-binding protein 1 (CREB1), T-cell receptor (TCR), nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NLRP3), DNA-dependent protein kinase (DNA-PK or PRKDC), and mitochondrial permeability transition pore (mPTP) were the major interaction partners of TSPOAP1, highlighting the role of TSPOAP1 in inflammation, particularly neuroinflammation. An analysis of the overlap between TSPO and TSPOAP1 Homo sapiens genes and top-ranked canonical pathways indicated that TSPO and TSPOAP1 interact via voltage-dependent anion-selective channels (VDAC1/2/3). A heat map analysis indicated that TSPOAP1 has critical roles in inflammatory, neuroinflammatory, psychiatric, and metabolic diseases and disorders, and cancer. Taken together, this information improves our understanding of the mechanism of action and biological functions of TSPOAP1 as well as its relationship with TSPO; furthermore, these results could provide new directions for in-depth functional studies of TSPOAP1 aimed at unmasking its detailed functions.
Radiological Imaging of Gastro-Entero-Pancreatic Neuroendocrine Tumors. The Review of Current Literature Emphasizing the Diagnostic Value of Chosen Imaging Methods
Authors: Półtorak-Szymczak Gabriela , Budlewski Tadeusz , Furmanek Mariusz Ireneusz , Wierzba Waldemar , Sklinda Katarzyna , Walecki Jerzy , Mruk Bartosz
Published: June 2021

Despite development of radiologic imaging, detection and follow-up of neuroendocrine neoplasms (NENs) still pose a diagnostic challenge, due to the heterogeneity of NEN, their relatively long-term growth, and small size of primary tumor. A set of information obtained by using different radiological imaging tools simplifies a choice of the most appropriate treatment method. Moreover, radiological imaging plays an important role in the assessment of metastatic lesions, especially in the liver, as well as, tumor response to treatment. This article reviews the current, broadly in use imaging modalities which are applied to the diagnosis of GEP-NETs, (the most common type of NENs) and put emphasis on the strengths and limitations of each modality.
Treatment Induced Cytotoxic T-Cell Modulation in Multiple Myeloma Patients
Authors: Barilà Gregorio , Pavan Laura , Vedovato Susanna , Berno Tamara , Lo Schirico Mariella , Arangio Febbo Massimiliano , Teramo Antonella , Calabretto Giulia , Vicenzetto Cristina , Gasparini Vanessa Rebecca , Fregnani Anna , Manni Sabrina , Trimarco Valentina , Carraro Samuela , Facco Monica , Piazza Francesco , Semenzato Gianpietro , Zambello Renato
Published: June 2021

The biology of plasma cell dyscrasias (PCD) involves both genetic and immune-related factors. Since genetic lesions are necessary but not sufficient for Multiple Myeloma (MM) evolution, several authors hypothesized that immune dysfunction involving both B and T cell counterparts plays a key role in the pathogenesis of the disease. The aim of this study is to evaluate the impact of cornerstone treatments for Multiple Myeloma into immune system shaping. A large series of 976 bone marrow samples from 735 patients affected by PCD was studied by flow analysis to identify discrete immune subsets. Treated MM samples displayed a reduction of CD4+ cells (p<0.0001) and an increase of CD8+ (p<0.0001), CD8+/DR+ (p<0.0001) and CD3+/CD57+ (p<0.0001) cells. Although these findings were to some extent demonstrated also following bortezomib treatment, a more pronounced cytotoxic polarization was shown after exposure to autologous stem cell transplantation (ASCT) and Lenalidomide (Len) treatment. As a matter of fact, samples of patients who received ASCT (n=110) and Len (n=118) were characterized, towards untreated patients (n=138 and n=130, respectively), by higher levels of CD8+ (p<0.0001 and p<0.0001, respectively), CD8+/DR+ (p=0.0252 and p=0.0001, respectively) and CD3+/CD57+ cells (p<0.0001 and p=0.0006, respectively) and lower levels of CD4+ lymphocytes (p<0.0001 and p=0.0005, respectively). We demonstrated that active MM patients are characterized by a relevant T cell modulation and that most of these changes are therapy-related. Current Myeloma treatments, notably ASCT and Len treatments, polarize immune system towards a dominant cytotoxic response, likely contributing to the anti-Myeloma effect of these regimens.
High-Density of FcγRIIIA+ (CD16+) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis
Authors: Denis Musquer Marie , Jouand Nicolas , Pere Morgane , Lamer Juliette Eugène , Bézieau Stéphane , Matysiak Tamara , Faroux Roger , Caroli Bosc François-Xavier , Rousselet Marie-Christine , Leclair François , Mosnier Jean-François , Toquet Claire , Gervois Nadine , Bossard Céline
Published: June 2021

Antibody-dependent cellular cytotoxicity (ADCC) in the anti-tumor effect of cetuximab in metastatic colorectal cancer (mCRC) is only based on the impact of FcγRIIIA (CD16) polymorphisms as predictive of therapeutic response. However, nature, density and therapeutic impact of FcγRIIIA+(CD16) effector cells in tumor remain poorly documented. Moreover, the inhibition of cetuximab-mediated ADCC induced by NK cells by the engagement of the new inhibitory CD94-NKG2A immune checkpoint has only been demonstratedin vitro. This multicentric study aimed to determine, on paired primary and metastatic tissue samples from a cohort of mCRC patients treated with cetuximab: 1) the nature and density of FcγRIIIA+(CD16) immune cells, 2) the expression profile of HLA-E/β2m by tumor cells as well as the density of CD94+immune cells and 3) their impact on both objective response to cetuximab and survival. We demonstrated that FcγRIIIA+(CD16) intraepithelial immune cells mainly correspond to tumor-associated neutrophils (TAN), and their high density in metastases was significantly associated with a better response to cetuximab, independently of the expression of the CD94/NKG2A inhibitory immune checkpoint. However, HLA-E/β2m, preferentially overexpressed in metastases compared with primary tumors and associated with CD94+tumor infiltrating lymphocytes (TILs), was associated with a poor overall survival. Altogether, these results strongly support the use of bispecific antibodies directed against both EGFR and FcγRIIIA (CD16) in mCRC patients, to boost cetuximab-mediated ADCC inRASwild-type mCRC patients. The preferential overexpression of HLA-E/β2m in metastases, associated with CD94+TILs and responsible for a poor prognosis, provides convincing arguments to inhibit this new immune checkpoint with monalizumab, a humanized anti-NKG2A antibody, in combination with anti- FcγRIIIA/EGFR bispecific antibodies as a promising therapeutic perspective inRASwild-type mCRC patients.
Mycophenolate Mofetil in the Treatment of Steroid-Dependent or Frequently Relapsing Nephrotic Syndrome in Children: A Meta-Analysis
Authors: Xiang Xin , Qiu Shi-Yuan , Wang Mo
Published: June 2021

Objectives: This meta-analysis aims to evaluate the efficacy and safety of the mycophenolate mofetil (MMF) in the treatment of steroid-dependent nephrotic syndrome (SDNS) or frequently relapsing nephrotic syndrome (FRNS) in children.

Methods: We searched for the studies especially the randomized controlled trials in PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wan Fang database. The data were analyzed by Review Manager 5.3 software. We used the GRADE pro-Guideline Development Tool online software to evaluate the quality of evidence.

Results: Finally, we identified 620 studies, of which we included five randomized controlled trials and one prospective cohort study with 447 children. The results showed the following: (1) the relapse-free survival rate within 1 year—the MMF group was superior to the levamisole group [ratio difference (RD) = 0.13, 95% CI (0.02, 0.24), P = 0.02] but not to the calcineurin inhibitors (CNIs) group [RD = −0.27, 95%CI (−0.40, −0.14), P < 0.0001]; (2) the number of relapses within 1 year—the MMF group was less than that in the CNIs and levamisole group [mean difference (MD) = −0.26, 95%CI (−0.45, −0.08), P = 0.005]; (3) the cumulative prednisone dosage—the MMF group was lower than that in the control group [standardized mean difference (SMD) = −0.32, 95%CI (−0.53, −0.11), P = 0.003]; (4) incidence of adverse reactions—there was no significant difference between the MMF group and the control group [RD = 0.02, 95%CI (−0.04, 0.09), P = 0.46].

Conclusion: The therapy of mycophenolate mofetil in the treatment of SDNS or FRNS in children has a certain advantage in reducing the number of relapses and cumulative prednisone dosage within 1 year when compared with the CNIs and levamisole. However, due to the limited quantity and quality of the included studies, the conclusions above need to be confirmed by more high-quality randomized controlled trials.
The Role of Lung Function Testing in Newborn Infants With Congenital Thoracic Arterial Anomalies
Authors: Columbo Claudia , Landolfo Francesca , De Rose Domenico Umberto , Massolo Anna Claudia , Secinaro Aurelio , Santangelo Teresa Pia , Trozzi Marilena , Campanale Cosimo Marco , Toscano Alessandra , Capolupo Irma , Bagolan Pietro , Dotta Andrea
Published: June 2021

Introduction: Congenital thoracic arterial anomalies (CTAAs), such as complete or incomplete vascular rings, pulmonary artery sling, and innominate artery compression syndrome, may cause severe tracheomalacia and upper airway obstruction. An obstructive ventilatory pattern at lung function testing (LFT) has been suggested in the presence of CTAA. The severity of obstruction may be evaluated by LFT. Little is known about the use of LFT in newborn infants with CTAA. The aim of our study is to evaluate the role of LFT in CTAA diagnosis.

Methods: This is a retrospective study, conducted between February 2016 and July 2020. All CTAA cases for whom LFT was performed preoperatively were considered for inclusion. Tidal volume (Vt), respiratory rate, and the ratio of time to reach the peak tidal expiratory flow over total expiratory time (tPTEF/tE) were assessed and compared to existing normative data. Demographics and CTAA characteristics were also collected.

Results: Thirty cases were included. All infants with CTAA showed a significantly reduced Vt and tPTEF/tE, compared to existing normative data suggesting an obstructive pattern.

No significant differences were found for LFT between cases with a tracheal obstruction <50% compared to those with tracheal obstruction ≥50%, or between cases with and without symptoms. Sixteen infants (53.3%) had respiratory symptoms related to CTAA. Of these, only two cases had also dysphagia.

Conclusion: LFT values were significantly reduced in cases with CTAA before surgery. LFT represents a potential feasible and non-invasive useful tool to guide diagnosis in the suspect of CTAA.
From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis
Authors: Silvagni Ettore , Missiroli Sonia , Perrone Mariasole , Patergnani Simone , Boncompagni Caterina , Bortoluzzi Alessandra , Govoni Marcello , Giorgi Carlotta , Alivernini Stefano , Pinton Paolo , Scirè Carlo Alberto
Published: June 2021

Psoriatic arthritis (PsA) is a chronic inflammatory immune-mediated disease with a burdensome impact on quality of life and substantial healthcare costs. To date, pharmacological interventions with different mechanisms of action, including conventional synthetic (cs), biological (b), and targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs), have been proven efficacious, despite a relevant proportion of failures. The current approach in clinical practice and research is typically “predictive”: the expected response is based on stratification according to clinical, imaging, and laboratory data, with a “heuristic” approach based on “trial and error”. Several available therapeutic options target the TNF-α pathway, while others are directed against the IL-23/IL-17A axis. Janus kinase inhibitors (JAKis), instead, simultaneously block different pathways, endowing these drugs with a potentially “broad-spectrum” mechanism of action. It is not clear, however, whether targeting a specific pathway (e.g., TNF-α or the IL-23/IL-17 axis) could result in discordant effects over other approaches. In particular, in the case of “refractory to a treatment” patients, other pathways might be hyperactivated, with opposing, synergistic, or redundant biological significance. On the contrary, refractory states could be purely resistant to treatment as a whole. Since chronic synovitis is one of the primary targets of inflammation in PsA, synovial biomarkers could be useful in depicting specific biological characteristics of the inflammatory burden at the single-patient level, and despite not yet being implemented in clinical practice, these biomarkers might help in selecting the proper treatment. In this narrative review, we will provide an up-to-date overview of the knowledge in the field of psoriatic synovitis regarding studies investigating the relationships among different activated proinflammatory processes suitable for targeting by different available drugs. The final objective is to clarify the state of the art in the field of personalized medicine for psoriatic disease, aiming at moving beyond the current treatment schedules toward a patient-centered approach.
Optical Response of Sila-Fulleranes in Interaction With Glycoproteins for Environmental Monitoring
Authors: Qasemnazhand Mohammad , Khoeini Farhad , Marsusi Farah
Published: June 2021

In this paper, we introduce new features of silicon in fullerane structures. Silicon, when placed in a fullerane structure, increases its electron affinity and electrophilicity index, compared to placement in a diamondoids structure. These nanoparticles can be used to make optical sensors to detect viral environments. In this work, we theoretically examine the changes in the UV-Visible spectrum of sila-fulleranes by interacting with viral spikes. As a result, we find out how the color of silicon nanoparticles changes when they interact with viruses. We apply N- and O-Links for viral glycoprotein structures, and Si20H20silicon dodecahedrane, respectively. Our computational method to obtain optimal structures and their energy in the ground and excited states, is density functional theory (DFT). Besides, to get the UV-Visible spectrum, time-dependent density functional theory (TD-DFT) approach has been used. Our results show that the color of sila-dodecahedrane is white, and turns green in the face of viral spikes. We can use the optical sensitivity of silicon nanoparticles, especially to identify environments infected with the novel coronavirus.
Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis
Authors: Denham Nathan C. , Pearman Charles M. , Madders George W. P. , Smith Charlotte E. R. , Trafford Andrew W. , Dibb Katharine M.
Published: June 2021

Background

Large animal models play an important role in our understanding of the pathophysiology of atrial fibrillation (AF). Our aim was to determine whether prospectively collected baseline variables could predict the development of sustained AF in sheep, thereby reducing the number of animals required in future studies. Our hypothesis was that the relationship between atrial dimensions, refractory periods and conduction velocity (otherwise known as the critical mass hypothesis) could be used for the first time to predict the development of sustained AF.

Methods

Healthy adult Welsh mountain sheep underwent a baseline electrophysiology study followed by implantation of a neurostimulator connected via an endocardial pacing lead to the right atrial appendage. The device was programmed to deliver intermittent 50 Hz bursts of 30 s duration over an 8-week period whilst sheep were monitored for AF.

Results

Eighteen sheep completed the protocol, of which 28% developed sustained AF. Logistic regression analysis showed only fibrillation number (calculated using the critical mass hypothesis as the left atrial diameter divided by the product of atrial conduction velocity and effective refractory period) was associated with an increased likelihood of developing sustained AF (Ln Odds Ratio 26.1 [95% confidence intervals 0.2–52.0] p = 0.048). A receiver-operator characteristic curve showed this could be used to predict which sheep developed sustained AF (C-statistic 0.82 [95% confidence intervals 0.59–1.04] p = 0.04).

Conclusion

The critical mass hypothesis can be used to predict sustained AF in a tachypaced ovine model. These findings can be used to optimise the design of future studies involving large animals.
Unraveling the Role of Shared Vision and Trust in Constructive Conflict Management of Family Firms. An Empirical Study From a Mixed Methods Approach
Authors: Alvarado-Alvarez Cristina , Armadans Immaculada , Parada María José , Anguera M. Teresa
Published: June 2021

Family firms are a unique setting to study constructive conflict management due to the influence of family ties of the owning family imprinting a sense of common purpose and shared destiny, and high levels of trust. We study the relationship between shared vision and trust that intervene in the adoption of constructive conflict management. To achieve our purpose, we carried out a systematic indirect observation using a mixed methods approach. We used the narratives of 17 semi-structured interviews, audio-recorded and transcribed, of family and non-family managers or directors from five Spanish family firms in the siblings' partnership stage, combined with documentary data obtained from different sources. Intra- and inter-observer reliability were confirmed. Results show a dynamic relationship between shared vision and specific components of trust (benevolence and ability) at different levels of conflict management. We also provide evidence of specific processes of concurrence-seeking and open-mindedness in family and ownership forums accounting for the relevance of family governance in these type of organizations. Family firms are a sum of several subsystems which exhibit a particular resources configuration. This study sheds light on constructive conflict management in family firms opening interesting avenues for further research and offering practical implications to managers, owners, and advisors.
“Just Ask Me”: The Importance of Respectful Relationships Within Schools
Authors: Brownlow Charlotte , Lawson Wenn , Pillay Yosheen , Mahony Joanne , Abawi Ding
Published: June 2021

An inclusive approach to education requires schools and educators to address the support needs and individual predispositions of all students. Our research highlights the crucial importance of effective and respectful communication with autistic students to facilitate their successful participation in schools. This paper explores the experiences of 24 autistic individuals aged 16–67 years, through synchronous semi-structured interviews and written responses. The research team comprised both autistic and allistic (non-autistic) researchers, who worked together to design the overall project, collect interview data, and analyse the data. Relationships were frequently discussed by participants and the importance of positive relationships was positioned as key to successful participation within educational contexts. Particularly damaging were assumptions made by teachers concerning individual ability based on labels given. Participants recalled ongoing challenges with resisting stereotypes and managing stigma, while trying to craft a positive autistic identity and advocate for rightful supports for their education. At the core of these negotiations were positive relationships, and teachers who asked participants what their needs were, and then listened and proactively responded to their answers. Recommendations for more positive schooling engagements with autistic young people are provided.
Completed Suicide With Violent and Non-violent Methods by the Elderly in Rural China: A Psychological Autopsy Study
Authors: Zhu Rong-Ting , Ma Zhen-Yu , Jia Cun-Xian , Zhou Liang
Published: June 2021

Background: Late-life suicide is a severe public health problem in rural China; however, knowledge regarding the specific characteristics and risk factors for completed suicide via violent and non-violent methods among elderly individuals in rural China is limited.

Methods: Subjects aged 60 years or older were selected from rural areas in Shandong, Hunan, and Guangxi provinces in China. This study was a 1:1 matched case-control design conducted by using the psychological autopsy method.

Results: According to the univariate analyses, the presence of mental disorder, higher degree of depression, loneliness, lack of social support, hopelessness, impulsivity, and increased quantity of life events were associated with suicide in both violent and non-violent methods. For violent suicide, another risk factor was the lack of pesticides at home. For non-violent suicide, other risk factors were not currently married, family suicide history, and alcohol use disorder (P < 0.05). Variables that remained in the logistic regression model were the severity of depressive symptoms for both violent and non-violent suicide. For non-violent suicide, the degree of hopelessness was another independent risk factor. In addition, violent suicides were more likely to lack pesticides at home, choose the spring season and have an increased quantity of life events than those who died by suicide via non-violent methods.

Conclusion: The major risk factor for both violent and non-violent suicide was the severity of depressive symptoms. Suicide prevention measures that focus on depression among this vulnerable population are urgently needed. Moreover, the characteristics of suicides via violent methods differed from those via non-violent methods among elderly individuals. Suicide prevention efforts should be tailored to the specific characteristics of the different suicide methods utilized by older adults in rural areas.
Bacteriological Quality and Heavy Metal Analysis of Packaged Water Produced in Lusaka, Zambia and Associated Quality Control Measures
Authors: Banda Rodney K. , Mubita Patricia , Moonga Given , Meki Chisala D.
Published: June 2021

Many people in the world lack safe basic drinking water sources and rely on untreated water source. Packaged water can be considered as an alternative to other water sources if measures are put in place to ensure its safety for consumption. This study aimed to assess the bacteriological quality and heavy metal analysis of packaged water produced in Lusaka, Zambia and associated quality control measures. A cross-sectional study was conducted in May 2019 where 18 brands of packaged water were analyzed for total and fecal coliforms as well as concentrations of Lead, Chromium, and Cadmium. The study found that 33.5% of the packaged water produced in Lusaka did not comply with the standard for drinking water on bacteriological quality. We also found that the concentrations for Lead were <0.01 mg/l in all the 17 samples, thus compliant to WHO/ZABS standards. Concentrations of Chromium were between 0.002 and 0.62 mg/l and compliance to the standard was 11.8%. Concentrations for Cadmium were between 0.009 and 0.2 mg/l against the acceptable concentration of <0.003 mg/l. Most brands of the packaged water did not conform to the standards for drinking water.
Employing Explainable AI to Optimize the Return Target Function of a Loan Portfolio
Authors: Gramespacher Thomas , Posth Jan-Alexander
Published: June 2021

In the recent years, data science methods have been developed considerably and have consequently found their way into many business processes in banking and finance. One example is the review and approval process of credit applications where they are employed with the aim to reduce rare but costly credit defaults in portfolios of loans. But there are challenges. Since defaults are rare events, it is—even with machine learning (ML) techniques—difficult to improve prediction accuracy and improvements are often marginal. Furthermore, while from an event prediction point of view, a non-default is the same as a default, from an economic point of view much more relevant to the end user it is not due to the high asymmetry in cost. Last, there are regulatory constraints when it comes to the adoption of advanced ML, hence the call for explainable artificial intelligence (XAI) issued by regulatory bodies like FINMA and BaFin. In our study, we will address these challenges. In particular, based on an exemplary use case, we show how ML methods can be adapted to the specific needs of credit assessment and how, in the case of strongly asymmetric costs of wrong forecasts, it makes sense to optimize not for accuracy but for an economic target function. We showcase this for two simple and ad hoc explainable ML algorithms, finding that in the case of credit approval, surprisingly high rejection rates contribute to maximizing profit.
Beyond a Zero-Sum Game: How Does the Impact of COVID-19 Vary by Gender?
Authors: Morgan Rosemary , Baker Peter , Griffith Derek M , Klein Sabra L. , Logie Carmen H , Mwiine Amon Ashaba , Scheim Ayden I , Shapiro Janna R. , Smith Julia , Wenham Clare , White Alan
Published: June 2021

Epidemics and pandemics, like COVID-19, are not gender neutral. Much of the current work on gender, sex, and COVID-19, however, has seemed implicitly or explicitly to be attempting to demonstrate that either men or women have been hardest hit, treating differences between women and men as though it is not important to understand how each group is affected by the virus. This approach often leaves out the effect on gender and sexual minorities entirely. Believing that a more nuanced approach is needed now and for the future, we brought together a group of gender experts to answer the question: how are people of different genders impacted by COVID-19 and why? Individuals working in women’s, men’s, and LGBTQ health and wellbeing wrote sections to lay out the different ways that women, men, and gender and sexual minorities are affected by COVID-19. We demonstrate that there is not one group “most affected,” but that many groups are affected, and we need to move beyond a zero-sum game and engage in ways to mutually identify and support marginalized groups.
Comparison of Classroom-Based Sedentary Time and Physical Activity in Conventional Classrooms and Open Learning Spaces Among Elementary School Students
Authors: Hartikainen Jani , Haapala Eero A. , Poikkeus Anna-Maija , Lapinkero Eero , Pesola Arto J. , Rantalainen Timo , Sääkslahti Arja , Gao Ying , Finni Taija
Published: June 2021

European children and adolescents spend most of their daily life and especially their school hours being sedentary which may increase their risk for chronic non-communicable diseases later in life. After the curriculum reform of Finnish basic education in 2014, most of the new or renovated comprehensive schools in Finland incorporate open and flexible classroom designs. Their open learning spaces may provide students opportunities to reduce sedentary behavior during school hours. Thus, waist-worn accelerometers were used to assess classroom-based sedentary time (ST), the number of breaks from sedentary time (BST), and physical activity (PA) among cross-sectional samples of 3rd and 5th grade students during two separate academic years in a school that underwent a renovation from conventional classrooms to open learning spaces. The cohort of 5th grade students before renovation had a smaller proportion of ST from total classroom time (56.97 ± 12.24%, n = 42 vs. 67.68 ± 5.61%, n = 28, mean difference = 10.71%-points, 95%CI = −15.65 to−5.77, p < 0.001), a greater number of BST per 60 min of classroom time (7.41 ± 1.16 breaks/h vs. 9.19 ± 1.59 breaks/h, mean difference = −1.78 breaks/h, 95%CI = −2.486 to −1.079, p < 0.001) and a greater proportion of light intensity PA (28.66 ± 9.99% vs. 22.56 ± 4.59%, mean difference = 6.10%, 95%CI = 2.56 to 9.64, p = 0.001) than the 5th grade cohort assessed after renovation. The cohort of 3rd grade student had a greater proportion of moderate-to-vigorous intensity PA (MVPA) after the renovation compared to the cohort assessed before the renovation [Mean Rank (Before) = 27.22, Mean Rank (After) = 37.58, U =524.0, p = 0.033]. Despite the greater ST found in 5th graders, schools with open learning spaces may facilitate BST or MVPA as observed in the 5th and 3rd grade cohorts in open learning spaces compared to the cohorts in conventional classrooms, respectively. Future studies should seek to investigate and develop teacher practices to capitalize the potential of open classrooms to reduce ST, since classroom renovation alone may not be a sufficient intervention as of itself. Longitudinal studies utilizing randomized controlled trials are warranted.
High-Protein Energy-Restriction: Effects on Body Composition, Contractile Properties, Mood, and Sleep in Active Young College Students
Authors: Roth Christian , Rettenmaier Lukas , Behringer Michael
Published: June 2021

Background: It is often advised to ensure a high-protein intake during energy-restricted diets. However, it is unclear whether a high-protein intake is able to maintain muscle mass and contractility in the absence of resistance training.

Materials and Methods: After 1 week of body mass maintenance (45 kcal/kg), 28 male college students not performing resistance training were randomized to either the energy-restricted (ER, 30 kcal/kg, n = 14) or the eucaloric control group (CG, 45 kcal/kg, n = 14) for 6 weeks. Both groups had their protein intake matched at 2.8 g/kg fat-free-mass and continued their habitual training throughout the study. Body composition was assessed weekly using multifrequency bioelectrical impedance analysis. Contractile properties of the m. rectus femoris were examined with Tensiomyography and MyotonPRO at weeks 1, 3, and 5 along with sleep (PSQI) and mood (POMS).

Results: The ER group revealed greater reductions in body mass (Δ −3.22 kg vs. Δ 1.90 kg, p < 0.001, partial η2 = 0.360), lean body mass (Δ −1.49 kg vs. Δ 0.68 kg, p < 0.001, partial η2 = 0.152), body cell mass (Δ −0.85 kg vs. Δ 0.59 kg, p < 0.001, partial η2 = 0.181), intracellular water (Δ −0.58 l vs. Δ 0.55 l, p < 0.001, partial η2 = 0.445) and body fat percentage (Δ −1.74% vs. Δ 1.22%, p < 0.001, partial η2 = 433) compared to the CG. Contractile properties, sleep onset, sleep duration as well as depression, fatigue and hostility did not change (p > 0.05). The PSQI score (Δ −1.43 vs. Δ −0.64, p = 0.006, partial η2 = 0.176) and vigor (Δ −2.79 vs. Δ −4.71, p = 0.040, partial η2 = 0.116) decreased significantly in the ER group and the CG, respectively.

Discussion: The present data show that a high-protein intake alone was not able to prevent lean mass loss associated with a 6-week moderate energy restriction in college students. Notably, it is unknown whether protein intake at 2.8 g/kg fat-free-mass prevented larger decreases in lean body mass. Muscle contractility was not negatively altered by this form of energy restriction. Sleep quality improved in both groups. Whether these advantages are due to the high-protein intake cannot be clarified and warrants further study. Although vigor was negatively affected in both groups, other mood parameters did not change.
Farm Production Diversity in Aquaculture Has Been Overlooked as a Contributor to Sustainability
Authors: Johnson Mark P.
Published: June 2021

Like many sectors, the expansion of aquaculture has issues related to sustainable resource use and environmental change. These challenges are widely recognised and are addressed with sectoral strategies. Even when culturing a single species, the specifics of impacts, constraints, and pressures are likely to vary in effects for different farm types. On the other hand, production efficiencies can drive farms towards homogeneity. A simple model is used in this study to demonstrate farm-scale budgets and the pressure to intensify production towards an optimum. A range of interventions can provide incentives for less intensive production: these include price premiums and altered cost bases. Integrated multitrophic aquaculture (IMTA) does not offer a route to less intensive production systems if the productivity of the extractive species (e.g., algae) is linked to the intensity of the fish farm, although alternative incentives for IMTA are possible. Increases in the intensity of production (as stocking density) can be mitigated by increasing farm capacity. An expanded production model suggests that this will lead to larger farms at relatively high stocking densities. Where farms are subject to variable economic and biological processes, this can lead to some combinations of intensity and capacity to have less variable earnings than others. The promotion of diverse aquaculture sectors may allow some of the ecological and social synergies available to smaller farms to be combined at a regional scale with the greater production of large farms. Cost, price and/or regulatory incentives are needed to create diverse production systems.
Overview of Mitigation Programs for Cattle Diseases in Austria
Authors: Roch Franz-Ferdinand , Conrady Beate
Published: June 2021

Background: The non-mandatory regulation of animal diseases at the European Union (EU) level enables member states to implement mitigation programs based on their own country-specific conditions such as priority settings of the governments, availability of financial resources, and epidemiological situation. This can result in a heterogeneous distribution of mitigation activities and prevalence levels within and/or between countries, which can cause difficulties for intracommunity trade. This article aims to describe the past, current, and future mitigation activities and associated prevalence levels for four animal diseases, i.e., enzootic bovine leukosis (EBL), infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV), bovine viral diarrhea (BVD), and bluetongue disease (BT) for Austria. Over a period of 40 years (1978–2020), regulations concerning EBL, IBR/IPV, BVD, and BT were retraced to analyze the changes of legislation, focusing on sampling, testing, and mitigation activities in Austria, and were linked to the collected diagnostic testing results. The study results clearly demonstrate the adoption of the legislation by the Austrian governments in dependency of the epidemiological situations. Furthermore, our study shows that, related to the forthcoming Animal Health Law on April 21, 2021, Austria has a good initial situation to achieve disease-free status and/or free from infection status based on the current available epidemiological situation and previously implemented mitigation activities. The study results presented here are intended to contribute to a better comparison of the eradication status across European countries for cattle diseases by providing information about the mitigation activities and data of testing results over a period of 40 years.
A Similarity Measurement with Entropy-Based Weighting for Clustering Mixed Numerical and Categorical Datasets
Authors: Que Xia , Jiang Siyuan , Yang Jiaoyun , An Ning
Published: June 2021

Many mixed datasets with both numerical and categorical attributes have been collected in various fields, including medicine, biology, etc. Designing appropriate similarity measurements plays an important role in clustering these datasets. Many traditional measurements treat various attributes equally when measuring the similarity. However, different attributes may contribute differently as the amount of information they contained could vary a lot. In this paper, we propose a similarity measurement with entropy-based weighting for clustering mixed datasets. The numerical data are first transformed into categorical data by an automatic categorization technique. Then, an entropy-based weighting strategy is applied to denote the different importances of various attributes. We incorporate the proposed measurement into an iterative clustering algorithm, and extensive experiments show that this algorithm outperforms OCIL and K-Prototype methods with 2.13% and 4.28% improvements, respectively, in terms of accuracy on six mixed datasets from UCI.
Effect of a Circular Slot on Hybrid Airship Aerodynamic Characteristics
Authors: Mano Sekar , Ajay Sriram RadhaKrishnan , Vinayagamurthy Ganesan , Pillai Subramania Nadaraja , Pasha Amjad Ali , Reddy Dwarshala Siva Krishna , Rahman Mustafa Mutiur
Published: June 2021

This numerical study reports the aerodynamic properties of a hybrid airship. The hybrid airships were designed by combining two semi-ellipsoids with a semi-discoid as the base model. From the base model, three different geometrics were identified to study their aerodynamic characteristics. A circular slot was provided between the pressure side and the suction side of the airship. The objective of this study was to realize the flow behavior, aerodynamic characteristics, and stability properties of such slotted hybrid flying vehicles. Interestingly, the results imply that the lift coefficient increases with an increase in the angle of attack for the slotted configurations; this is because the flow separation is delayed due to the slot opening, which in turn is due to the flow of energies from the high-pressure region to the bottom through the slots. The delayed stall angle was 50 degrees, which was 10% more than that of the base model. Aerodynamic characteristics are discussed based on surface pressure, coefficient of lift, and coefficient of drag for various slotted hybrid airships.
Harvest Techniques: Hand-Pulling and Its Potential Impact on the Archaeobotanical Record Vis a Vis Near Eastern Plant Domestication
Authors: Abbo Shahal , Lev-Yadun Simcha , Gopher Avi
Published: June 2021

A “cultivation prior to domestication”, or a “pre-domestication cultivation” phase features in many reconstructions of Near Eastern plant domestication. Archaeobotanists who accept this notion search for evidence to support the assumption regarding a wild plant’s cultivation phase, which in their view, preceded and eventually led to plant domestication. The presence of non-crop plant remains in the archaeobotanical record interpreted as arable weeds, i.e., weeds of cultivation, is viewed as a strong argument in support of the pre-domestication cultivation phase. Herein, we show that the simple practice of harvest by hand-pulling (uprooting) has the potential to secure an almost weed-free harvest. Indeed, rather clean (weed-free) Neolithic seed caches from a range of relevant sites were documented in archaeobotanical reports. These reports, alongside ethnographic observations suggest that (in certain cases) ancient harvest may have been carried out by selective hand-pulling. Hence, one has no reason to view archaeobotanical assemblages from occupation sites as fully representative of cultivated fields. Therefore, the concept of “arable—pre-domestication weeds”, its logic, and its potential contribution to the prevailing reconstructions of Near Eastern plant domestication need be reconsidered.
Investigation of Controllable Modes in Active Vibration Cancellation Induced by Piezoelectric Patches
Authors: Han Yuying , Sheng Meiping , Fu Xiaohan
Published: June 2021

Piezoelectric (PZT) patches are widely preferred for actuators and sensors for achieving active vibration cancellation (AVC). When PZT actuators and sensors are placed at the region of maximum strain energy for structural modes, there are still uncontrollable and controllable modes in the actual application. When an uncontrollable mode is excited, the structural vibration problem may not be solved by AVC, and may even be aggravated. However, a few studies have specifically targeted this problem. In this study, the controllable modes of a plate with free boundaries are investigated to ensure the AVC effect. To specify the controllable modes in advance, a criterion for controllable modes is proposed. The proposed criterion is firstly obtained by defining the ratio of the open-loop and closed-loop energies of AVC, and then simplified by considering the dominating modes. Corresponding simulations and experiments are conducted on a smart plate consisting of PZT patches to verify the correctness of the theoretical analysis. Results show that the proposed criterion is reliable to specify the controllable modes. The vibration response of the plate is significantly attenuated at the selected controllable mode, and conversely enlarged at a specified uncontrollable mode. It is verified that controllable modes can be effectively predicted by the proposed criterion, which promotes the application of AVC.
Performing Hydrological Monitoring at a National Scale by Exploiting Rain-Gauge and Radar Networks: The Italian Case
Authors: Bruno Giulia , Pignone Flavio , Silvestro Francesco , Gabellani Simone , Schiavi Federico , Rebora Nicola , Giordano Pietro , Falzacappa Marco
Published: June 2021

Hydrological monitoring systems relying on radar data and distributed hydrological models are now feasible at large-scale and represent effective early warning systems for flash floods. Here we describe a system that allows hydrological occurrences in terms of streamflow at a national scale to be monitored. We then evaluate its operational application in Italy, a country characterized by various climatic conditions and topographic features. The proposed system exploits a modified conditional merging (MCM) algorithm to generate rainfall estimates by blending data from national radar and rain-gauge networks. Then, we use the merged rainfall fields as input for the distributed and continuous hydrological model, Continuum, to obtain real-time streamflow predictions. We assess its performance in terms of rainfall estimates from MCM, using cross-validation and comparison with a conditional merging technique at an event-scale. We also assess its performance against rainfall fields from ground-based data at catchment-scale. We further evaluate the performance of the hydrological system in terms of streamflow against observed data (relative error on high flows less than 25% and Nash–Sutcliffe Efficiency greater than 0.5 for 72% and 46% of the calibrated study sections, respectively). These results, therefore, confirm the suitability of such an approach, even at national scale, over a wide range of catchment types, climates, and hydrometeorological regimes, and for operational purposes.
A Two-Stage Closed-Loop Supply Chain Pricing Decision: Cross-Channel Recycling and Channel Preference
Authors: Pan Wenjun , Lin Miao
Published: June 2021

This paper focuses on the pricing problem of a two-stage closed-loop supply chain (CLSC) considering the cross-channel recycling and channel preference based on a single manufacturer and a single traditional retailer. The pricing decision problem raises from the manufacturer’s direct sales and the retailer’s retailing including recycling. Managers need to focus on intelligible management considering consumer channel preferences, cross-channel recovery and pricing strategies. According to game theory, centralized and decentralized CLSC decision models are used to provide an efficient solution to managers for the pricing problem. The centralized model consists of differential and uniform pricing strategy and the decentralized model consists of manufacturer-led Stackelberg, retailer-led Stackelberg and Nash equilibrium game, respectively. The impact of cross-channel recycling rate and channel preference on pricing and profitability in a two-stage CLSC system is explained elaborately in this study. The results show that cross-channel recovery rates and consumer channel preferences have a direct significant impact on pricing strategies including profit allocation decisions in CLSC. It demonstrated that different channel preferences leading to different pricing strategies and decision for manufacturers and retailers choices. Manufacturer’s pricing decreases when channel preferences are constant and cross-channel recovery rates increase. Retailer’s pricing remains stable as the cross-channel recovery rate has less affected on it. Furthermore, if the cross-channel recovery rates increase, then the manufacturers pricing decreases and retailers pricing increases. This information will be a helpful guideline for the manager to select suitable pricing strategies based on the company scenario.