bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of metabolic syndrome on prognosis of patients with surgically treated esophageal cancer: a meta-analysis
Authors: Zhang Zhao , Huang Congcong , Xu Mengshan
Published: May 2024

Background

Metabolic syndrome (MetS) has been related to the increased incidence of esophageal cancer (EC). The aim of the study was to evaluate the influence of MetS on prognosis of patients with surgically treated EC in a systematic review and meta-analysis.

Methods

An extensive search was conducted on PubMed, Embase, Web of Science, Wanfang, and CNKI to identify relevant cohort studies. Random-effects models were employed to combine the findings, taking into account the potential influence of heterogeneity.

Results

Seven cohort studies involving 4332 patients with stage I-III EC who received surgical resection were included. At baseline, 608 (14.0%) patients had MetS. Pooled results suggested that MetS were associated with a higher risk of postoperative complications (risk ratio [RR]: 1.30, 95% confidence interval [CI]: 1.03 to 1.64, p = 0.03; I2 = 0%). However, the overall survival (RR: 1.07, 95% CI: 0.75 to 1.52, p = 0.71; I2 = 80%) and progression-free survival (RR: 1.27, 95% CI: 0.53 to 3.00, p = 0.59; I2 = 80%) were not significantly different between patients with and without MetS. Subgroup analyses suggested that the results were not significantly modified by study design (prospective or retrospective), histological type of EC (squamous cell carcinoma or adenocarcinoma), or diagnostic criteria for MetS (p values indicating subgroup difference all > 0.05).

Conclusion

Although MetS may be associated with a moderately increased risk of postoperative complications in patients with EC under surgical resection, the long-term survival may not be different between patients with and without MetS.
Possibilities and efficiency of MSC co-transfection for gene therapy
Authors: Christoffers Sina , Seiler Lisa , Wiebe Elena , Blume Cornelia
Published: May 2024

Mesenchymal stem/stromal cells (MSCs) are not only capable of self-renewal, trans-differentiation, homing to damaged tissue sites and immunomodulation by secretion of trophic factors but are also easy to isolate and expand. Because of these characteristics, they are used in numerous clinical trials for cell therapy including immune and neurological disorders, diabetes, bone and cartilage diseases and myocardial infarction. However, not all trials have successful outcomes, due to unfavourable microenvironmental factors and the heterogenous nature of MSCs. Therefore, genetic manipulation of MSCs can increase their prospect. Currently, most studies focus on single transfection with one gene. Even though the introduction of more than one gene increases the complexity, it also increases the effectivity as different mechanism are triggered, leading to a synergistic effect. In this review we focus on the methodology and efficiency of co-transfection, as well as the opportunities and pitfalls of these genetically engineered cells for therapy.

Graphical abstract
AiZynthFinder 4.0: developments based on learnings from 3 years of industrial application
Authors: Saigiridharan Lakshidaa , Hassen Alan Kai , Lai Helen , Torren-Peraire Paula , Engkvist Ola , Genheden Samuel
Published: May 2024

We present an updated overview of the AiZynthFinder package for retrosynthesis planning. Since the first version was released in 2020, we have added a substantial number of new features based on user feedback. Feature enhancements include policies for filter reactions, support for any one-step retrosynthesis model, a scoring framework and several additional search algorithms. To exemplify the typical use-cases of the software and highlight some learnings, we perform a large-scale analysis on several hundred thousand target molecules from diverse sources. This analysis looks at for instance route shape, stock usage and exploitation of reaction space, and points out strengths and weaknesses of our retrosynthesis approach. The software is released as open-source for educational purposes as well as to provide a reference implementation of the core algorithms for synthesis prediction. We hope that releasing the software as open-source will further facilitate innovation in developing novel methods for synthetic route prediction. AiZynthFinder is a fast, robust and extensible open-source software and can be downloaded from https://github.com/MolecularAI/aizynthfinder.
Ursonic acid from medicinal herbs inhibits PRRSV replication through activation of the innate immune response by targeting the phosphatase PTPN1
Authors: Yang Yuanqi , Gao Yanni , Sun Haifeng , Bai Juan , Zhang Jie , Zhang Lujie , Liu Xing , Sun Yangyang , Jiang Ping
Published: May 2024

Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), has caused substantial economic losses to the global swine industry due to the lack of effective commercial vaccines and drugs. There is an urgent need to develop alternative strategies for PRRS prevention and control, such as antiviral drugs. In this study, we identified ursonic acid (UNA), a natural pentacyclic triterpenoid from medicinal herbs, as a novel drug with anti-PRRSV activity in vitro. Mechanistically, a time-of-addition assay revealed that UNA inhibited PRRSV replication when it was added before, at the same time as, and after PRRSV infection was induced. Compound target prediction and molecular docking analysis suggested that UNA interacts with the active pocket of PTPN1, which was further confirmed by a target protein interference assay and phosphatase activity assay. Furthermore, UNA inhibited PRRSV replication by targeting PTPN1, which inhibited IFN-β production. In addition, UNA displayed antiviral activity against porcine epidemic diarrhoea virus (PEDV) and Seneca virus A (SVA) replication in vitro. These findings will be helpful for developing novel prophylactic and therapeutic agents against PRRS and other swine virus infections.
New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases
Authors: Gu Shuchen , Derynck Rik , Chen Ye-Guang , Feng Xin-Hua
Published: May 2024

The family of secreted dimeric proteins known as the Transforming Growth Factor-β (TGF-β) family plays a critical role in facilitating intercellular communication within multicellular animals. A recent symposium on TGF-β Biology - Signaling, Development, and Diseases, held on December 19–21, 2023, in Hangzhou, China, showcased some latest advances in our understanding TGF-β biology and also served as an important forum for scientific collaboration and exchange of ideas. More than twenty presentations and discussions at the symposium delved into the intricate mechanisms of TGF-β superfamily signaling pathways, their roles in normal development and immunity, and the pathological conditions associated with pathway dysregulation.
Kalman filter for radio source power and direction of arrival estimation
Authors: Cano Cyril , Arab Nawel , Chaumette Éric , Larzabal Pascal , El Korso Mohammed Nabil , Vin Isabelle
Published: May 2024

Images are an important source of information for spacecraft navigation. Based on an image and a known attitude, triangulation techniques (intersection or resection) are often used for positioning and navigation. In the resection problem, an observer estimate its unknown location by using angle measurements to points at known locations (i.e., landmarks), the localization performance depending on the accuracy of the angle measurements. As a contribution to resection for spacecraft navigation, we considers the dynamic image estimation problem based on radio interferometry, i.e., image of radio source power, where the measurements are sample covariance matrices (SCMs). Considering the case where several measurements are available as well as a known dynamic linear model of image evolution, a.k.a a linear state model, the minimum mean-squared error image estimator (MMSE) is given by the Kalman filter (KF) or one of its variants. However standard Kalman-like filters are not a priori suitable for the problem at hand since the measurements (i.e., SCMs) cannot be formulated analytically as a function of state parameters to be estimated (i.e., radio source power). In fact, this lack of analytical formulation can be circumvented by a statistical linear fitting allowing the SCMs to be expressed in terms of the state. This linear fitting introduces an additive residual noise, equivalent to a measurement noise, whose covariance matrix depends on the current state, a non-standard case for a measurement model. The covariance matrix of the residual noise is derived whatever the distributions of the radio sources and of the additive noise at the samples level, unveiling the contribution of their multivariate kurtosis. The proposed method is evaluated on simulated data representative of a dynamic radio interferometry framework. The results show that the proposed method is capable of effectively tracking moving radio sources in complex scenes with theoretical guaranties when the signal multivariate kurtosis is known.
Interventions to reduce inequalities for pregnant women living with disadvantage in high-income countries: an umbrella review protocol
Authors: Vousden N. , Geddes-Barton D. , Roberts N. , Knight M.
Published: May 2024

Background

Women who live with disadvantages such as socioeconomic deprivation, substance misuse, poor mental health, or domestic abuse face inequalities in health before, during, and after pregnancy and for their infants through to childhood. Women do not experience these factors alone; they accumulate and interact. Therefore, there is a need for an overview of interventions that work across health and social care and target women at risk of inequalities in maternal or child health.

Methods

Systematic review methodology will be used to identify systematic reviews from high-income countries that describe interventions aiming to reduce inequalities for women who experience social disadvantage during pregnancy. We will describe the range of interventions and their effectiveness in reducing inequalities in maternal or child health. Any individual, hospital, or community-level activity specific to women during the pre-conception, antenatal, or postpartum period up to 1 year after birth will be included, regardless of the setting in which they are delivered. We will search eight electronic databases with the pre-determined search strategy and supplement them with extensive grey literature searches. We will present a narrative synthesis, taking into account the quality assessment and coverage of included studies.

Discussion

Inequalities in maternal and child health are a key priority area for national policymakers. Understanding the range and effectiveness of interventions across the perinatal period will inform policy and practice. Identifying gaps in the evidence will inform future research.

Systematic review registration

PROSPERO CRD42023455502.
Practitioner perspectives on working with older patients in opioid agonist treatment (OAT) in Norway: opportunities and challenges
Authors: Todd-Kvam John , Clausen Thomas
Published: May 2024

Background

Norway has a growing proportion of ageing opioid agonist treatment (OAT) patients, with 42% of the 8300 Norwegian OAT patients aged over 50 in 2022. This study aims to explore practitioners’ views and experiences from treatment of ageing OAT patients.

Methods

Data were collected as a series of semi-structured interviews with treatment staff (roles interviewed: doctor, psychologist, social worker, nurse, and learning disability nurse). Participants were recruited from three OAT outpatient clinics, one with an urban catchment area and two with a mix of urban and rural. The interviews incorporated questions on patients’ somatic and mental health, strengths and weaknesses of the service for this group, and patients’ quality of life.

Results

Older patients were perceived to be more often stable in terms of substance use and housing situation, but also experiencing some key challenges in terms of cognitive impairment, loneliness and isolation, and comorbidities. Both the practitioner-patient relationship and healthcare interactions outside OAT had the potential to impact treatment quality positively or negatively depending on how they were managed.

Conclusions

Treating older patients in a way that respects and enhances their dignity is important. We argue that this requires better services for those whose functioning is impacted by cognitive impairment/dementia, an age-informed treatment model for this patient group, along with urgent work to improve municipal-level services given practitioners describe them as unacceptable in certain areas.
Locusta migratoria hydrolysates attenuate lipopolysaccharide (LPS)/D-Galactosamine (D-Gal)-induced cytotoxicity and inflammation in Hep G2 cells via NF-κB signaling suppression
Authors: Zheng Jiaxiang , Jung Sunyoon , Ha Jung-Heun , Jeong Yoonhwa
Published: May 2024

The prolonged state of hepatic inflammation can lead to liver damage, a critical driving force in the progression of liver-related diseases. Locusta migratoria (LM), an edible insect, is recognized for its protein richness and potential to produce a range of bioactive polypeptides, presenting a novel solution for liver disease. This study investigated the hepatoprotective effects of LM hydrolysates in human hepatoma G2 (Hep G2) cells challenged with lipopolysaccharide (LPS)/D-Galactosamine (D-Gal), a model of liver injury. Remarkably, LM hydrolysates significantly ameliorated cell damage, as evidenced by the inhibition of the LPS/D-Gal-induced decrease in cell viability and reduction in lactate dehydrogenase (LDH) release. Furthermore, LM hydrolysates alleviated the release of aspartate aminotransferase (AST) from cells exposed to LPS/D-Gal and lowered the secretion of inflammatory cytokines while suppressing the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a key pathway in inflammation. In particular, LM-N hydrolysate mitigated hepatotoxicity by attenuation of inflammatory responses to reduce interleukin 6 (IL-6) levels, and NF-κB nuclear translocation. These findings suggest that LM hydrolysates could potentially offer hepatoprotective effects by mitigating the inflammatory responses induced by LPS/D-Gal.
A computational two-scale approach to cancellous bone remodelling
Authors: Steinmann Paul , Schmidt Ina , Pivonka Peter , Papastavrou Areti
Published: May 2024

We propose a novel two-scale (meso-macro-scale) approach to computationally capture cancellous bone remodelling allowing for efficient and effective numerical implementation. Therein, the macro-scale is governed by the well-established kinematics and kinetics of one-scale continuum bone remodelling. However, the constitutive behaviour is not postulated phenomenologically at the macro-scale, but rather follows from the meso-scale. There, for the sake of computational efficiency, the trabecular architecture is idealised as a truss network with the cross-sectional area of the trabeculae adapting to mechanical loading. Then, the meso- and the macro-scale are coupled through up- and down-scaling. Computational results on benchmark problems from bio-mechanics demonstrate that the proposed two-scale approach is effective from a modelling perspective and efficient from a computational perspective. In particular, it automatically captures anisotropy resulting from the irregular trabecular architecture at the meso-scale, and, most importantly, enables the direct investigation of different trabecular structures at the meso-scale, thereby serving as a virtual “magnifiying glass”. As an outlook, the proposed two-scale approach to cancellous bone remodelling provides an excellent launch pad for further extension, e.g., by considering more complex trabecular architectures and/or through inclusion of micro-scale bone cellular activities.
Co-created augmented reality app and its impact on the effectiveness of learning a foreign language and on cultural knowledge
Authors: Di Fuccio Raffaele , Kic-Drgas Joanna , Woźniak Joanna
Published: May 2024

This paper addresses the limited exploration of the impact of virtual and augmented reality on the learning process, particularly within the context of foreign language learning among young learners. Motivated by this research gap, the EULALIA, conducted from 2019 to 2023 (2019-1-IT02-KA203-063228), sought to evaluate the efficacy of integrating technology in language education. Specifically, the study investigates the influence of virtual and augmented reality on foreign language learning, examining its effects on subjectively assessed cultural knowledge, and workflow during classes, as perceived by educators. Involving 239 learners, the study employed a pre/post survey methodology, wherein participants provided feedback before and after working with the EULALIA application or traditional learning methods. The quantitative analysis of survey data was complemented by semi-structured interviews with participating teachers, providing additional insights. The results indicate a statistically significant increase in cultural knowledge among the group utilizing augmented reality. The findings suggest a positive impact on students’ learning progression, and workflow during classes. This research contributes valuable insights into the potential of integrating virtual and augmented reality in language education, offering a foundation for future pedagogical advancements.
Google Gemini as a next generation AI educational tool: a review of emerging educational technology
Authors: Imran Muhammad , Almusharraf Norah
Published: May 2024

This emerging technology report discusses Google Gemini as a multimodal generative AI tool and presents its revolutionary potential for future educational technology. It introduces Gemini and its features, including versatility in processing data from text, image, audio, and video inputs and generating diverse content types. This study discusses recent empirical studies, technology in practice, and the relationship between Gemini technology and the educational landscape. This report further explores Gemini’s relevance for future educational endeavors and practical applications in emerging technologies. Also, it discusses the significant challenges and ethical considerations that must be addressed to ensure its responsible and effective integration into the educational landscape.
Holocene loess in the Himalayas piedmont of southeastern Nepal
Authors: Latrubesse Edgardo M. , Nugraha Abang M. S.
Published: May 2024

Loess, loess-like, sandy loess, and sandy-silty fluvial–aeolian deposits are intercalated to fluvial sediments and lie on a flat surface under intense agricultural land use in Bardibas, Mahottari district, central Nepal. To identify the depositional processes and provenance, we carried out geochemical, mineralogical, SEM, and grain-size analyses. Optically stimulated luminescence (OSL) dating shows the aeolian deposits are from the late Holocene (1.0–4.8 ka). Our results demonstrate that the loess and loess-like deposits (i) were dominantly sourced locally from deflation Quaternary sediments of the Terai Plain; (ii) are related to the composition of Siwalik rocks; and (iii) were deposited during dry periods of weak activity of the Indian Summer Monsoon.
Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid
Authors: Qi Yi-Ke , Pan Jiang , Zhang Zhi-Jun , Xu Jian-He
Published: May 2024

Background

Dodecanedioic acid (DDA), a typical medium-chain dicarboxylic fatty acid with widespread applications, has a great synthetic value and a huge industrial market demand. Currently, a sustainable, eco-friendly and efficient process is desired for dodecanedioic acid production.

Results

Herein, a multi-enzymatic cascade was designed and constructed for the production of DDA from linoleic acid based on the lipoxygenase pathway in plants. The cascade is composed of lipoxygenase, hydroperoxide lyase, aldehyde dehydrogenase, and unidentified double-bond reductase in E. coli for the main cascade reactions, as well as NADH oxidase for cofactor recycling. The four component enzymes involved in the cascade were co-expressed in E. coli, together with the endogenous double-bond reductase of E. coli. After optimizing the reaction conditions of the rate-limiting step, 43.8 g L− 1 d− 1 of DDA was obtained by a whole-cell one-pot process starting from renewable linoleic acid.

Conclusions

Through engineering of the reaction system and co-expressing the component enzymes, a sustainable and eco-friendly DDA biosynthesis route was set up in E. coli, which afforded the highest space time yield for DDA production among the current artificial multi-enzymatic routes derived from the LOX-pathway, and the productivity achieved here ranks the second highest among the current research progress in DDA biosynthesis.

Graphical Abstract
The Effect of Cannabidiol on Subjective Responses to Endurance Exercise: A Randomised Controlled Trial
Authors: McCartney Danielle , Irwin Christopher , Bawa Zeeta , Palmer Blake , Sahinovic Ayshe , Delang Nathan , Cox Gregory R. , Desbrow Ben , Lau Namson S. , McGregor Iain S.
Published: May 2024

Background

Exercise is known to improve health. However, it can be unpleasant, often inducing negative feelings, or ‘affect’. Cannabidiol (CBD), a non-intoxicating constituent of the cannabis plant, has been reported to enhance the subjective experience of exercise; specifically, in trained individuals performing fixed-intensity endurance activity. Here, we investigated the effects of CBD on subjective responses to exercise under more ecologically valid conditions; namely, in recreationally active individuals performing self-paced endurance activity.

Methods

A randomised, double-blind, placebo-controlled, crossover trial was conducted at Griffith University between July 17 and August 28, 2023. Griffith University students studying sports nutrition were invited to take part, with eligible volunteers ≥ 18 years of age and able to perform endurance exercise. Participants ingested placebo or 150 mg CBD in two soft-gel capsules 90 min before completing a self-paced 25-lap (10 km) run around an outdoor athletics track (400 m, synthetic). The primary outcomes were affective valence during exercise, assessed on completion of laps 6, 12, 18 and 24 using the ‘Feelings Scale’, and positive and negative affect, assessed at baseline, pre-run and post-run using the ‘Positive and Negative Affect Schedule’. Exercise enjoyment, motivation and self-efficacy, the core features of the ‘runner’s high’ (i.e., euphoria, pain, anxiety, sedation), perceived exertion and run time were also assessed.

Results

Fifty-two participants were randomised and 51 were included in the final sample (n = 22 female; 22 [21–25] years). Exercise induced negative affect (i.e., at the time of undertaking) and increased pain. CBD did not counteract either response. In fact, CBD had no significant effects on any of the outcomes measured. In contrast, exercise, once completed, increased positive affect, and decreased negative affect and anxiety.

Conclusions

CBD (150 mg, oral) does not appear to enhance the subjective experience of self-paced endurance exercise in recreationally active individuals. Nor, however, does it appear to compromise it. These findings suggest that CBD use is safe under exercise conditions and unlikely to impede physical activity participation. Our study also reaffirms the powerful mood-enhancing effects of exercise.

Trial Registration

Registered with the Australian New Zealand Clinical Trials Registry (www.anzctr.org.au) on May 31, 2023 (Trial ID: ACTRN12623000593639).
Navigating bioenergy horizons: a critical examination of Europe’s potential, with Belgium as a case study
Authors: Colla Martin , Verleysen Kevin , Blondeau Julien , Jeanmart Hervé
Published: May 2024

Estimates of the energy potential of the different energy sources are essential for modelling energy systems. However, the potential of biomass is debatable due to the numerous dimensions and assumptions embedded. It is thus important to investigate further the final potential to understand their implications. Therefore, this study analyses European studies assessing biomass potential and proposes a critical discussion on the different results to converge to a realistic range of potentials for 2030. Biomass is divided into four categories: forestry products, agricultural residues, energy crops and other waste, each with sub-categories. Belgium is used as a case study to highlight the convergences and divergences of the studies. Having a national case study allows for more precise analyses through in-depth comparisons with national data and reports. The potential estimates are compared with the current production for each category in order to have a better view of the gap to be bridged. From these national perspectives, the European potential can be better apprehended. The results show that the realistic potentials for 2030 for Belgium and Europe are somewhat in the lower range of the estimates of the different studies: from 30 to 41 TWh and from 2000 to 2500 TWh, respectively. The forestry biomass is already well exploited with a slight potential increase, while the agricultural residues present the most significant potential increase. The realistic potential for energy crops in Belgium turned out to be close to the minimum estimates. Indeed, the implications of those crops are considerable regarding the agricultural structure and logistics. This article emphasises that no energy potential is neutral, as it involves a specific system in terms of agriculture, forestry or waste management, with broader social, economic or environmental implications. Consequently, using one estimate rather than another is not a trivial matter; it has an impact on the system being modelled from the outset.
Pooled prevalence and associated factors of teenage pregnancy among women aged 15 to 19 years in sub-Saharan Africa: evidence from 2019 to 2022 demographic and health survey data
Authors: Mekonen Enyew Getaneh
Published: May 2024

Background

Teenage pregnancy is becoming one of the most common social and public health problems worldwide, with the highest prevalence in sub-Saharan Africa. Health risks and adverse outcomes of pregnancy and childbirth among adolescent girls are the commonest cause of the global burden of maternal morbidity and mortality. This study is intended to determine the pooled prevalence and determinants of teenage pregnancy in sub-Saharan Africa using the most recent demographic and health survey data (2019–2022).

Methods

A cross-sectional study was conducted using data from the most recent demographic and health surveys of four countries (Kenya, Tanzania, Gabon, and Cameroon) in sub-Saharan Africa conducted between 2019 and 2022. A total weighted sample of 12,829 teenagers aged 15 to 19 years was included in the study. Data extracted from demographic and health survey data sets were cleaned, recorded, and analyzed using STATA/SE version 14.0 statistical software. Multilevel mixed-effects logistic regression was used to determine the factors associated with the dependent variable. Finally, variables with a p-value ≤ 0.05 and an adjusted odds ratio with a 95% confidence interval were declared statistically significant.

Results

The pooled prevalence of teenage pregnancy among women aged 15 to 19 years was 18.15% (95% CI: 17.49, 18.83). Teenage pregnancy was positively associated with the respondent’s age [AOR = 2.97; 95% CI (2.55, 3.46)], educational status [AOR = 2.21; 95% CI (1.62, 3.03)] and [AOR = 1.80; 95% CI (1.54, 2.12)], wealth status [AOR = 2.61; 95% CI (2.12, 3.22)] and [AOR = 1.65; 95% CI (1.33, 2.05)], relation to the household head [AOR = 2.09; 95% CI (1.60, 2.72)], and unmet need for contraception [AOR = 14.3; 95% CI (11.5, 17.8)]. On the other hand, it was negatively associated with marital status [AOR = 0.08; 95% (0.07, 0.10)], working status [AOR = 0.75; 95% CI (0.64, 0.88)], age at first sex [AOR = 0.68; 95% CI (0.58, 0.80)], contraceptive use [AOR = 0.25; 95% CI (0.20, 0.30)], contraceptive knowledge [AOR = 0.27; 95% CI (0.19, 0.40)], and community contraceptive utilization [AOR = 0.85; 95% CI (0.73, 0.99)].

Conclusion

In the current study, one out of six young women aged 15 to 19 experienced teenage pregnancy. Therefore, addressing unmet needs for family planning, improving women’s educational status, and giving special attention to teenagers with low educational and economic status are recommended.
Plasma CD24 level as a promising prognostic biomarker of hepatocellular carcinoma
Authors: Rasmy Hany Samir , Awad Emad Ahmad , Mohamed Eslam Safwat , Boshra Amal Samy , Ibrahim Shereen Abdel Monem , Isaac Amira
Published: May 2024

Background

Hepatocellular carcinoma constitutes the most common primary hepatic cancer and remains a major medical burden in both developing and developed world. It ranks fifth in terms of global cases and second in terms of deaths for males.CD24 is known as a heavily glycosylated cell surface molecule that is highly expressed in a wide variety of human malignancies. It plays an important role in self-renewal, proliferation, migration, invasion, and drug resistance. The aim of this work was to evaluate the potential role of serum CD24 in the diagnosis and prediction of response to interventional therapy among hepatocellular carcinomas.

Methods

This study included 40 adult Egyptian patients who had liver cirrhosis and hepatocellular carcinoma (HCC group). Another group of 20 patients with liver cirrhosis only served as controls (Cirrhosis group). All patients underwent standard laboratory tests and abdominal ultrasound. For HCC patients, a triphasic CT scan, alpha-fetoprotein was done. CD24 levels were measured in all patients, and in HCC patients at baseline and one month after intervention.

Results

Baseline CD24 was significantly higher among HCC group in comparison to cirrhosis group (19.463 ± 8.573 vs. 0.725 ± 0.125 mg/L) with an overall p value < 0.001. Serum CD24 levels significantly declined after locoregional treatment from 19.463 ± 8.573 mg/L to 3.569 ± 1.248 mg/L (p < 0.001). Baseline CD24 was a useful marker in eligibility for HCC intervention with 80% sensitivity and 74.29% specificity at a cutoff of ≤ 23 mg/L, and it also had 62.96% sensitivity and 100% specificity in prediction of cure after locoregional treatment at a cutoff of ≤ 19.5 mg/L.

Conclusion

CD24 could be a helpful diagnostic and prognostic marker for HCC, as its baseline level is useful in predicting both eligibility for intervention and cure after locoregional treatment.
An ecological view on the correlates of sedentary behavior in Brazilian adolescents: a cross-sectional study with network analysis
Authors: Ywgne José , Luz Leonardo G. O. , Thuany Mabliny , Lima Cayo , Araujo Raphael , Silva Ellen , Magalhães Kleberton , Bandeira Paulo , Silva Danilo R.
Published: May 2024

Background

Sedentary behavior has been identified as a public health concern. The present study analyzed the correlates of sedentary behavior in Brazilian adolescents through network analysis, in the light of an ecological approach.

Methods

The sample consisted of 126,354 adolescents, participating in the fourth edition of the Brazilian National School Health Survey. The variables were grouped into domains, namely intrapersonal, interpersonal, perceived environment, school variables, food variables, active behavior domains, and leisure sedentary behavior. The data were analyzed using network analysis.

Results

The results reinforce that sedentary behavior is independent of the assessed active behavior domains, despite being weakly related to physical activity outside physical education classes (− 0.073). The variable with the greatest closeness and one of the variables with the greatest expected influence in the model was having internet at home, which was associated with private schools (− 0.230), having a cell phone (0.378), having a computer or notebook at home (0.409), and a greater weekly frequency of watching television (0.169). Furthermore, having internet at home was strongly associated with an increase in sedentary behavior (− 0.197), which, in turn, was linked to greater consumption of treats (0.067) and sodas (0.052).

Conclusions

We concluded that having internet at home is associated with longer sedentary time, which, in turn, is associated with greater consumption of foods of poorer nutritional quality. Interventions on sedentary behavior should be specific for population subgroups and consider actions in different levels.
Modeling mobile shales under contraction: Critical analyses of new analog simulations of shale tectonics and comparison with salt-bearing systems
Authors: Dooley Tim P. , Soto Juan I. , Reber Jacqueline E. , Hudec Michael R. , Peel Frank J. , Apps Gillian M.
Published: May 2024

Weak substrates, such as salt and mobile shales, exert a strong control on deformation styles in all structural settings, especially those undergoing contraction. Despite both materials being very weak, they are mechanically very different. Salt is weak and will flow in a ductile fashion under most geologic conditions, whereas shales only become mobile after reaching a critical state. Many sandbox-style physical or analog modeling studies have typically used a salt analog, viscous silicone polymer, as a proxy for mobile shales. However, to more accurately model mobile shale behavior, the model material needs to exhibit yield strength. One such material is Carbopol, which is made up of microgel grains that are elasto-plastic, separated by a viscous interstitial ﬂuid. The abundance of the grains depends on the concentration of the mixture. Our results show that Carbopol does behave much differently than the traditional salt analog during contraction. Polydimethylsiloxanes typically undergoes bulk deformation and inflation under contraction, whereas Carbopol forms discrete, intense shear zones and contains zones of little to no strain where its yield strength has not been exceeded. Below the shale analog, brittle layers typically form imbricate thrust stacks, jacking up the overburden, with shear zones propagating out from thrust tips along and through the shale proxy. Strain analyses reveal complex switching of activity within the Carbopol and overlying sediments. Models reveal that even a very thin layer of Carbopol can act as a highly efficient detachment, and form more geologically realistic shortening structures, especially where these detachments are vertically stacked and horizontally offset. We believe that Carbopol is a powerful mobile-shale analog and opens new modeling directions because, as far as we are aware, this material has never been incorporated into a traditional sandbox model. Future work will seek to incorporate this material into more complex and 3D sandbox-style models.
Unification of Efforts to Improve Global Access to Cancer Therapeutics: Report From the 2022/2023 Access to Essential Cancer Medicines Stakeholder Summit
Authors: Briercheck Edward , Pyle Doug , Adams Cary , Atun Rifat , Booth Christopher , Dent Jennifer , Garcia-Gonzalez Pat , Ilbawi Andre , Jazieh Abdul Rahman , Kerr David , Knaul Felicia , Kobayashi Emily , Lim Christopher , Maza Maurizio , Milner Danny , Navarro Maria Fernanda , O'Brien Meg , Rodriguez-Galindo Carlos , Sullivan Richard , Torode Julie , Vokes Everett , Gralow Julie
Published: May 2024

PURPOSE

There is an urgent need to improve access to cancer therapy globally. Several independent initiatives have been undertaken to improve access to cancer medicines, and additional new initiatives are in development. Improved sharing of experiences and increased collaboration are needed to achieve substantial improvements in global access to essential oncology medicines.

METHODS

The inaugural Access to Essential Cancer Medicines Stakeholder Meeting was organized by ASCO and convened at the June 2022 ASCO Annual Meeting in Chicago, IL, with two subsequent meetings, Union for International Cancer Control World Cancer Congress held in Geneva, Switzerland, in October 2022 and at the ASCO Annual Meeting in June of 2023. Invited stakeholders included representatives from cancer institutes, physicians, researchers, professional societies, the pharmaceutical industry, patient advocacy organizations, funders, cancer organizations and foundations, policy makers, and regulatory bodies. The session was moderated by ASCO. Past efforts and current and upcoming initiatives were initially discussed (2022), updates on progress were provided (2023), and broad agreement on resulting action steps was achieved with participants.

RESULTS

Summit participants recognized that while much work was ongoing to enhance access to cancer therapeutics globally, communication and synergy across projects and organizations could be enhanced by providing a platform for collaboration and shared expertise.

CONCLUSION

The summit resulted in new cross-stakeholder insights and planned collaboration addressing barriers to accessing cancer medications. Specific actions and timelines for implementation and reporting were established.
Prevalence and Spectrum of AR Ligand-Binding Domain Mutations Detected in Circulating-Tumor DNA Across Disease States in Men With Metastatic Castration-Resistant Prostate Cancer
Authors: Antonarakis Emmanuel S. , Zhang Nicole , Saha Jayati , Nevalaita Liina , Ikonen Tarja , Tsai L. Jill , Garratt Chris , Fizazi Karim
Published: May 2024

PURPOSE

Metastatic castration-resistant prostate cancer (mCRPC) is typically treated with agents directly or indirectly targeting the androgen receptor (AR) pathway. However, such treatment is limited by resistance mechanisms, including the development of activating mutations in the AR ligand-binding domain ( AR-LBD).

METHODS

This study evaluated a database of over 15,000 patients with advanced prostate cancer (PC) undergoing comprehensive circulating-tumor DNA analysis (Guardant360, Redwood City, CA) between 2014 and 2021, with associated clinical information from administrative claims (GuardantINFORM database).

RESULTS

Of 15,705 patients with PC included, 54% had mCRPC at the time of their blood draw. Of those, 49% had previous treatment with an AR pathway inhibitor (ARPi). AR-LBD mutation prevalence was 15% in patients with mCRPC who were untreated with a next-generation ARPi, 22% in those after one line of ARPi therapy, and 24% in those after two lines of ARPi treatment. Next-generation ARPi treatment yielded an increase in AR L702H and T878A/S mutations after abiraterone, and an increase in AR L702H and F877L mutations after enzalutamide. AR-LBD+ patients demonstrated unique biology, including increased concurrent mutations in the cell-cycle, wingless-related integration site, homologous recombination repair, and phospho-inositide 3-kinase pathways (all P < .0005), and greater low-level (copy number <10) AR amplifications ( P = .0041). AR-LBD+ patients exhibited worse overall survival (OS) relative to a matched cohort of AR-LBD– patients (50.1 v 60.7 months, unadjusted log-rank P = .013).

CONCLUSION

This large database analysis demonstrates that AR-LBD mutation prevalence increases after next-generation ARPi use. AR-LBD+ tumors demonstrate unique biology (more oncogenic pathway mutations and low-level AR amplification) and reduced OS. These findings inform the development of novel therapies designed to circumvent AR-mediated therapeutic resistance.
Role of the Casimir force in micro- and nanoelectromechanical pressure sensors
Authors: Klimchitskaya G. L. , Korotkov A. S. , Loboda V. V. , Mostepanenko V. M.
Published: May 2024

The Casimir force caused by the electromagnetic fluctuations is computed in the configurations of micro- and nanoelectromechanical pressure sensors using Si membranes and either Si or Au-coated Si substrates. It is shown that if, under the influence of external pressure, the membrane-substrate separation drops to below 100 nm, the Casimir force makes a profound effect on the sensor functioning. There exists the maximum value of external pressure depending on the sensor parameters such that it finds itself in a state of unstable equilibrium. For this and larger pressures, the Casimir force leads to a collapse of the sensor, which loses its functionality. For any smaller external pressures, there exist two equilibrium positions, one of which is unstable and another one is stable, at smaller and larger membrane-substrate separations, respectively. The latter can be safely used for the pressure measurements. Possible applications of the obtained results in the design of micro- and nanoelectromechanical pressure sensors of next generations with further decreased dimensions are discussed.
LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH
Authors: Tanida Ryota , Goto Hisanori , Takayama Hiroaki , Nakano Yujiro , Oo Hein Ko , Galicia-Medina Cynthia Monserrat , Takahashi Kenta , Ishii Kiyo-aki , Goli Arman Syah , Matsuzaka Takashi , Harada Kenichi , Takamura Toshinari
Published: May 2024

Leukocyte cell-derived chemotaxin 2 (LECT2) is a protein initially isolated as a neutrophil chemotactic factor. We previously found that LECT2 is an obesity-associated hepatokine that senses liver fat and induces skeletal muscle insulin resistance. In addition, hepatocyte-derived LECT2 activates macrophage proinflammatory activity by reinforcing the lipopolysaccharide (LPS)-induced c-Jun N-terminal kinase signaling. Based on these findings, we examined the effect of LECT2 deletion on nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) caused by bacterial translocation. We created the bacterial translocation-mediated NAFLD/NASH model using LECT2 knockout mice (LECT2 KO) with 28 times a low-dose LPS injection under high-fat diet feeding conditions. LECT2 deletion exacerbated steatosis and significantly reduced p38 phosphorylation in the liver. In addition, LECT2 deletion increased macrophage infiltration with decreased M1/M2 ratios. LECT2 might contribute to protecting against lipid accumulation and macrophage activation in the liver under pathological conditions, which might be accomplished via p38 phosphorylation. This study provides novel aspects of LECT2 in the bacterial translocation-mediated NAFLD/NASH model.
A Research Note on Community Resilience Estimates: New U.S. Census Bureau Data With an Application to Excess Deaths From COVID-19
Authors: Anders John , Carpenter Craig Wesley , Willyard Katherine Ann , DeSalvo Bethany
Published: May 2024

In this research note, we describe the results of the first validation study of the U.S. Census Bureau's new Community Resilience Estimates (CRE), which uses Census microdata to develop a tract-level vulnerability index for the United States. By employing administrative microdata to link Social Security Administration mortality records to CRE, we show that CRE quartiles provide more stable predictions of COVID-19 excess deaths than single demographic categorizations such as race or age, as well as other vulnerability measures including the U.S. Centers for Disease Control and Prevention's Social Vulnerability Index (SVI) and the Federal Emergency Management Agency's National Risk Index (NRI). We also use machine learning techniques to show that CRE provides more predictive power of COVID-19 excess deaths than standard socioeconomic predictors of vulnerability such as poverty and unemployment, as well as SVI and NRI. We find that a 10-percentage-point increase in a key CRE risk measure is associated with one additional death per neighborhood during the initial outbreak of COVID-19 in the United States. We conclude that, compared with alternative measures, CRE provides a more accurate predictor of community vulnerability to a disaster such as a pandemic.
Retirement Makes You Old? Causal Effect of Retirement on Biological Age
Authors: Furuya Shiro , Fletcher Jason M.
Published: May 2024

Retirement is a critical life event for older people. Health scholars have scrutinized the health effects of retirement, but its consequences on age-related diseases and mortality are unclear. We extend this body of research by integrating measurements of biological age, representing the physiological decline preceding disease onset. Using data from the UK Biobank and a fuzzy regression discontinuity design, we estimated the effects of retirement on two biomarker-based biological age measures. Results showed that retirement significantly increases biological age for those induced to retire by the State Pension eligibility by 0.871–2.503 years, depending on sex and specific biological age measurement. Given the emerging scientific discussion about direct interventions to biological age to achieve additional improvements in population health, the positive effect of retirement on biological age has important implications for an increase in the State Pension eligibility age and its potential consequences on population health, public health care policy, and older people's labor force participation. Overall, this study provides novel empirical evidence contributing to the question of what social factors make people old.
Weathering the Storm
Authors: Archer Nicole , Schreiber Rachel
Published: May 2024

Over the last two decades, red umbrellas have increasingly appeared in campaigns to end violence against sex workers, oppose harmful legislation, advocate for decriminalization, commemorate lost community members, and broadly express sex worker pride. Originating with the work of the artist/activist Tadej Pogačar and the P.A.R.A.S.I.T.E. Museum of Contemporary Art’s contribution to the 2001 Venice Biennale (“The Prostitute Pavilion”), red umbrellas were originally presented as a visual symbol of self-help, organization, and protection for sex workers. Since then the red umbrella has been adopted and adapted to a broader range of meanings related to sex worker activism, including decriminalization, opposition to antitrafficking discourse, and more. The umbrella has also come to convey the “big tent” concept—that all sex workers are together under its canopy, unified as one coalition. But like any symbol, the red umbrella’s use has limitations. The red umbrella risks amplifying negative rhetoric employed by the antitrafficking movement, which casts sex workers as passive victims in need of salvation, or of oversimplifying a complex, multifaceted political movement. The Curated Spaces section of this issue presents a brief history of the red umbrella as a symbol for sex workers’ rights and images that demonstrate its varied uses.
Differences in Teachers’ Assessments of Students by English Learner Status
Authors: Zhu Maria
Published: May 2024

This paper investigates potential disparities in how teachers perceive academic achievement between English Learner (EL) students and their non-EL counterparts. Using data on elementary and middle school students in North Carolina, I compare teachers' academic assessments of EL students to those of non-EL students in the same class with the same standardized-test-based achievement. Results reveal that teachers hold more negative perceptions of achievement for EL students compared to academically comparable non-EL peers. These results emphasize the added difficulties experienced by EL students in academic settings, compounding the challenges they already encounter from language barriers.
Aggregation Bias in the Measurement of US Global Value Chains
Authors: Flaaen Aaron , Kamal Fariha , Lee Eunhee , Yi Kei-Mu
Published: May 2024

This paper employs US census microdata to construct establishment-level measures of global value chains (GVCs) and then assesses aggregation bias—the bias occurring when an entire industry is essentially treated as a single establishment. Our establishment-level measures indicate little slowdown in GVC expansion between 2002 and 2012. Related, the aggregation bias is negative, and it increased during this period. A decomposition reveals that most of the increase is from within establishments with high export and import intensities. Our results suggest that granular GVC measures will provide further understanding about how firms and economies adjust to shocks.