bluuebunny/crossref_metadata_2025 huggingface dataset:
lncRNA MALAT1, MEG3, and PANDAR Levels may be Potential Diagnostic Biomarkers in Multiple Myeloma
Authors: ERÖKSÜZ ÖZDİNÇ Elvin , HEKİMLER ÖZTÜRK Kuyaş , MUTLU İÇDUYGU Fadime , ÖZBALCI Demircan
Published: August 2023

Aim: Long non-coding RNAs (lncRNAs) play a significant role in the development of various diseases, including cancer, and have been investigated as potential diagnostic and prognostic markers. The specific mechanisms underlying their involvement in the progression and development of multiple myeloma (MM), as well as their potential as diagnostic markers, remain to be fully elucidated. This study aimed to elucidate the involvement of lncRNAs in the pathogenesis of MM, explore their relationship with clinical parameters, and assess their potential as biomarkers for MM diagnosis.

Material and Methods: Patients above 18 years of age, diagnosed with MM and not yet receiving treatment, were included in the study. The expression levels of three lncRNAs (MALAT1, PANDAR, MEG3) regulated by the p53 gene were determined in a study involving 19 patients diagnosed with MM and 20 healthy volunteers. The expression levels were determined using RT-PCR.

Results: The levels of plasma lncRNAs were observed to be significantly down-regulated (p
SYSTEM DYNAMICS: AN APPROACH TO MODELING SUPPLY CHAIN PERFORMANCE MEASUREMENT
Authors: Liu Peide , Atifeh Morteza , Khorshidnia Mohsen , Taheri Seyed Ghiasuddin
Published: August 2023

The complexity of goods and services in the current world has caused individual companies that do not have the help and cooperation of other organizations to face many problems for their survival. In this paper, a system dynamics model was proposed by creating a cause-effect curve to increase supply chain (SC) performance with an emphasis on agility and flexibility (AAF) indicators. The proposed model aimed to reduce cost and delivery time and increase customer satisfaction by considering AAF indicators. To this end, the concepts used were first introduced. Afterward, the important goals were identified by reviewing the existing literatures and interviewing experts in the field of AAF indicators in the studied SC. In the next step, the model was constructed by determining the cause-and-effect (CAE) relationships between the variables. Finally, by developing and simulating different scenarios, the results showed that AAF alone and absolutely cannot enhance profitability. By implication, to increase profitability, AAF do not need to be enhanced to the highest level, but an optimal point must be found. Finally, an optimal level of AAF was estimated. by using this system and considering that this system supports the production line, the ability to respond to sudden demands is increased and as a result, the speed of covering these demands increases.
Flyby Galaxy Encounters with Multiple Black Holes Produce Star-forming Linear Features
Authors: Chen Nianyi , LaChance Patrick , Ni Yueying , Di Matteo Tiziana , Croft Rupert , Natarajan Priyamvada , Bird Simeon
Published: August 2023

We look for simulated star-forming linear features such as the one recently discovered by van Dokkum et al. in the cosmological hydrodynamical simulation ASTRID. Among the runaway black holes in ASTRID, none are able to produce clear star-forming wakes. Meanwhile, flyby encounters, typically involving a compact galaxy (with a central black hole) and a star-forming galaxy (with a duo of black holes), reproduce remarkably well many of the key properties (length and linearity, recent star formation, etc.) of the observed star-forming linear feature. We predict that the feature will persist for approximately 100 Myr in such a system and hence constitute a rare event. The feature contains a partly stripped galaxy (with M
gal = 109–1010
M
⊙) and a dual black hole system (M
BH = 105–107
M
⊙) in its brightest knot. The X-ray emission from AGN in the knot should be detectable in such systems. After 100–200 Myr from the first flyby, the galaxies merge, leaving behind a triple black hole system in a (still) actively star-forming early-type remnant of mass ∼5 × 1010
M
⊙. Follow-up JWST observations may be key for revealing the nature of these linear features by potentially detecting the older stellar populations constituting the bright knot. Confirmation of such detections may therefore help discriminate a flyby encounter from a massive black hole wake to reveal the origin of such features.
Australian National Species List: Name Identifier Management and Linkages
Authors: Fuchs Anne , Whitbread Greg , Cooper Endymion
Published: August 2023

The Australian National Species List (AuNSL) is the provider of names and taxonomy for significant national biodiversity data infrastructures including the Atlas of Living Australia, the Terrestrial Ecosystem Research Network, the Biodiversity Data Repository, and the Species Profile and Threats Database. The AuNSL mints persistent identifiers for names covered by the codes of nomenclature and name-like objects such as phrase names. To ensure sustainability of identifiers, a mapping service is provided to always resolve all AuNSL identifiers including historical and deprecated forms. Names are used as the building blocks for recording taxon name usages and taxon concepts. We provide services for matching, disambiguation and taxonomic resolution of names.

The AuNSL does not exist in a vacuum and supports identifier mappings to external resources and related systems such as the International Plant Name Index (IPNI), Zoobank, the Biodiversity Heritage Library. To enable this integration, persistent identifiers from original and/or significant sources are required and this data is currently limited and incomplete within the AuNSL. To address this issue, we need to look backwards for improved ways of matching to existing persistent identifiers and forward to improving capture of taxonomic novelties and name-like objects and their identifiers.
Spatiotemporal retrieval and feature analysis of air pollution episodes
Authors: Yin Peng-Yeng
Published: August 2023

Air pollution has inevitably come along with the economic development of human society. How to balance economic growth with a sustainable environment has been a global concern. The ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is particularly life-threatening because these tiny aerosols could be inhaled into the human respiration system and cause millions of premature deaths every year. The focus of most relevant research has been placed on apportionment of pollutants and the forecast of PM2.5 concentration measures. However, the spatiotemporal variations of pollution regions and their relationships to local factors are not much contemplated in the literature. These local factors include, at least, land terrain, meteorological conditions and anthropogenic activities. In this paper, we propose an interactive analysis platform for spatiotemporal retrieval and feature analysis of air pollution episodes. A domain expert can interact with the platform by specifying the episode analysis intention considering various local factors to reach the analysis goals. The analysis platform consists of two main components. The first component offers a query-by-sketch function where the domain expert can search similar pollution episodes by sketching the spatial relationship between the pollution regions and the land objects. The second component helps the domain expert choose a retrieved episode to conduct spatiotemporal feature analysis in a time span. The integrated platform automatically searches the episodes most resembling the domain expert's original sketch and detects when and where the episode emerges and diminishes. These functions are helpful for domain experts to infer insights into how local factors result in particular pollution episodes.
Modeling and analyzing an opinion network dynamics considering the environmental factor
Authors: Yin Fulian , Wang Jinxia , Jiang Xinyi , Huang Yanjing , Yang Qianyi , Wu Jianhong
Published: August 2023

With the development of Internet technology, social media has gradually become an important platform where users can express opinions about hot events. Research on the mechanism of public opinion evolution is beneficial to guide the trend of opinions, making users' opinions change in a positive direction or reach a consensus among controversial crowds. To design effective strategies for public opinion management, we propose a dynamic opinion network susceptible-forwarding-immune model considering environmental factors (NET-OE-SFI), which divides the forwarding nodes into two types: support and opposition based on the real data of users. The NET-OE-SFI model introduces environmental factors from infectious diseases into the study of network information transmission, which aims to explore the evolution law of users' opinions affected by the environment. We attempt to combine the complex media environmental factors in social networks with users' opinion information to study the influence of environmental factors on the evolution of public opinion. Data fitting of real information transmission data fully demonstrates the validity of this model. We have also made a variety of sensitivity analysis experiments to study the influence of model parameters, contributing to the design of reasonable and effective strategies for public opinion guidance.
Negritud e injusticia hermenéutica en Frantz Fanon
Authors: De Oto Alejandro , Jerade Miriam
Published: August 2023

El presente artículo ofrece una revisión crítica de la noción de injusticia hermenéutica de Miranda Fricker a partir de dos elementos de la obra de Frantz Fanon: 1) la «historicidad» como una carga cultural en las categorías sociales que es productiva, lo que exige cuestionar la definición de injusticia hermenéutica como ausencia o tergiversación de categorías; 2) la redefinición que Fanon hizo del «esquema corporal» de Merleau Ponty: la experiencia vivida del cuerpo, lo que muestra que los recursos hermenéuticos no son solo categorías mentales, sino que están imbricados con la dimensión material. Nuestro objetivo es mostrar cómo estos dos elementos de la teoría fanoniana hacen una contribución a la noción de injusticia hermenéutica y por qué esta es relevante para entender la injusticia estructural del racismo.
Thixomolding of Magnesium - Efficient Process Industrialization by Combining a Digital Twin and Systematic Casting Trials
Authors: Bramann Horst , Rockmann Hartmut , Zhang Yu Xiao , Yandamuri Sai
Published: August 2023

Besides the realization of the technical specification of a casting, aspects such as resource minimization, cost awareness and robustness of the defined quality requirements are taking major priority, especially in the current global economic situation. Lightweight design, in that respect, is a central topic far beyond the automotive industry and characterizes in particular the ongoing research and development of innovative magnesium cast components. As a resource-efficient alternative to traditional die casting, magnesium-thixomolding offers the benefit of low energy consumption and eschews the necessity of protective gases. The identification of significant influencing factors between process settings, shear and time dependent material properties of semi-solid magnesium, the machine capabilities and the resulting casting quality are the basis for effective product and process design of magnesium thixomolding. Obtaining this knowledge is only possible through methodical process analysis and systematic design of experiments. YIZUMI Germany, together with MAGMA, demonstrates the methodical evaluation of a reliable process window for an AZ91D magnesium “box” component, using a demo mold on a UN1250MGII thixomolding machine. The work shows how a systematic combination of virtual and real casting experiments is used to identify a concrete process layout and generate important knowledge on process variations, robustness as well as control limits. In particular, the comparison of virtual and real casting experiments using statistical methods generates a comprehensive understanding of the impact and limits of different process variables, such as fraction solid, mold temperature and injection speeds. Furthermore it is possible to predict the influence of the gating and component design on the process. The methodological use of qualified casting simulation enables the development of an optimized component design and the determination of a suitable process window with minimized economic or productive risks long before the first component is manufactured – a step towards more resource efficiency and sustainability!
CALPHAD Optimization of the Composition of EN AC-46000 Secondary Alloys for Semi-Solid Casting Processes
Authors: Ferraro Simone , Bongiovanni Andrea , Suarez Lopez Inma , Palumbo Mauro , Baricco Marcello , Castellero Alberto
Published: August 2023

In semi-solid metal casting processes a slurry, obtained operating in the temperature window between the liquidus and the solidus curve of the phase diagram of the alloy (32.7 °C for AlSi8, 11.3 °C for AlSi11), is injected into the mould. Since the control over the process parameters becomes more complicated as the involved quantities increase, to apply these processes on an industrial scale it is necessary to widen as much as possible this narrow temperature window. This goal can be obtained by tailoring the concentration of elements constituting the alloy. A EN AC-46000 secondary alloy was selected for this study, because of its wide use in foundries. Using a CALPHAD approach, various Al-Si-based pseudo-binary phase diagrams containing main constituents of the alloy (Cu, Zn, Fe, Mg, Mn, Ni, Cr and Ti) were studied, keeping the Si content fixed from 8 to 11 wt.% and the Al content as a complement. The composition limits of acceptability of the commercial alloy EN AC-46000 were used as extremes of the simulation field. The study was then proceeded investigating the pseudo-ternary diagrams, keeping silicon and a second element fixed and a third element variable for all possible combinations. Further constituent elements of the alloy were progressively added, considering all main constituents of the alloy, and evaluating how the concentration of these elements can extend the temperature window. Mg, Fe, Mn and Ti are the most promising candidates for achieving this goal. The results of this study can provide foundries with a prediction tool to define more restrictive ranges of acceptability than those of the commercial alloy, allowing them to estimate through a simple chemical analysis whether scrap of variable composition entering the plant are suitable for the SSM process or they need preliminary corrections of composition.
Quality Control of Semi-Solid Die Casting by Filling Pressure Based on Machine Learning Method
Authors: Wang Zhi Yuan , Hu Xiao Gang , Lu Hong Xing , Zhu Qiang
Published: August 2023

In the actual semi-solid die-casting production, the existence of several uncertain factors can impose an effect on the final product quality, which poses a challenge to semi-solid production. However, data analysis such as machine learning (ML) can help producers eliminate this problem. In order to quickly identify defective castings, a new model of predicting quality by real-time injection pressure data will be generated in terms of ML in this research. Quality assessment will be based on non-filling defect, density and tensile properties. The result of cross-validation shows that the classifier can achieve a confidence level of 0.95 for the quality classification. In addition, this research will find key intervals by the importance given by the model and analyze the effects of process on filling pressure. According to the result of feature screening, the surface quality problems are related to speed-pressure conversion and feeding displacement of plunger, the flowing state of slurry in filling affects the formation of defects and tensile properties. This work will make semi-solid die casting more automatically and efficiently, and thus provides support for semi-solid sustainable development.
Rheological Modeling of 7075 Aluminum Alloy Semi-Solid Slurry and its Application in the Simulation of SEED Rheocasting Process
Authors: Lu Hong Xing , Meng Xiao Xia , Bunnareaksathya Nov , Zhu Qiang
Published: August 2023

Rheocasting technology has been successfully applied to produce aluminum alloy parts of automobile and communication equipment. However, its application scope is still limited. One reason is that the strength of the applied alloys is limited. In recent years, lots of researchers have tried to use 7075 aluminum alloy in the rheocasting process because this alloy has excellent mechanical properties. In this work, the rheological behavior of 7075 aluminum alloy semi-solid slurry is studied through shear stress-controlled test and shear rate-controlled test. Then the constitutive parameters in Power-Law (PL) model or Carreau-Yasuda (CY) model of non-Newtonian fluid are determined. The models are used to simulate the flow behavior of 7075 aluminum alloy semi-solid slurry in Swirled Enthalpy Equilibration Device (SEED) rheocasting process. The simulation results indicate that the CY model derived from the shear rate sweep test is more suitable for simulating the flow behavior of 7075 aluminum alloy semi-solid slurry during rheocasting than the other models.
A Molecular Dynamics Study of Nucleation and Grain Growth of Novel Al-15Mg2Si-4.5Si Composite during Rapid Cooling Based Semi Solid Slurry Preparation
Authors: Mukherjee Indrani , Das Prosenjit
Published: August 2023

Owing to their several attractive features such as high hardness, high elastic modulus, light weight, high strength to weight ratio, high thermal conductivity, and high temperature strength, composites from Al-Mg2Si family offers promise towards deployment in several industries such as automobile, aerospace, marine, defence and electronic. The present molecular dynamics (employing LAMMPS) based simulation study is one of the first attempt to investigate the nucleation and grain growth mechanisms of Mg2Si phase at atomic level in case of novel Al-15Mg2Si-4.5Si composite, during semi-solid processing. Modified embedded atom method (MEAM) potential has been used to study the atomic interactions in the composite. Reaching the melt state at 1000 K, the temperature of the system is first decreased from 1000 K to 853 K and then the system is held at 853 K for 100 ps. The simulations are performed with three different cooling rates. With lowering of temperature, randomly distributed Mg and Si atoms form atomic clusters at arbitrary locations within the system, which is the nucleation stage for Mg2Si phase formation. Cluster size, radial distribution function has been used to investigate the structural evolution of Mg-Si clusters. Cooling rate significantly influences the grain size as well as the grain growth kinetics. The information about the thermodynamic state of the system has been revealed by extracting the values of internal energy, enthalpy, specific heat. during the slurry preparation and isothermal holding stages. The growth mechanism of Mg2Si nucleus has been characterized from the temporal variation of (Mg + Si) atoms taking part in the cluster formation. Power-law variation is observed in the cooling stage whereas a linear variation is observed in the isothermal stage.
Impact of Financial Capability on Financial Stress of Small and Medium Entrepreneurs in Sri Lanka: Special Reference to the Western Province
Authors: Jayasekara B. E. A.
Published: August 2023

A significant role is played by Small and Medium Enterprises in creating employment worldwide. Nevertheless, the sector has failed to achieve the desired level of growth despite its unexpected success as a result of significant issues dealt in each individual nation. The main limiting factor for the reduction in growth of Small and Medium Entrepreneurs is the level of financial stress encountered because of financial incapability and rising commitments. Hence the question surfaces on the impact of financial capability on financial stress of Small and Medium Entrepreneurs in Sri Lanka. The present research is primarily focused on measuring financial capability based on a variety of variables ranging from financial resources, financial self-efficacy and financial management competency. Small and Medium Entrepreneurs residing in three districts of the Western Province namely Colombo, Kalutara and Gampaha were chosen to collect the primary data by a questionnaire distributed and the required number of 250 respondents for the sample study were singled out by the stratified proportional random sampling method. Subsequently the data was analyzed using the IBM SPSS- 23 and AMOS. According to the study results, Small and Medium Entrepreneurs residing in Sri Lanka possess higher levels of financial capability and lower degree of financial stress. Further, the Small and Medium Entrepreneurs in Sri Lanka demonstrated a significant level of financial management competency, financial self-efficacy and a moderate number of financial resources. In conclusion the researcher concludes that financial capability has a direct moderate level significant negative impact on financial stress. Finally, study recommends SME should develop their financial skills and capabilities to overcome the financial stress.
COVID-19 infection in chronic spontaneous urticaria treated with omalizumab: two case reports
Authors: D'Erme Angelo Massimiliano , Fidanzi Cristian , Romanelli Marco , Dini Valentina , Bagnoni Giovanni , Janowska Agata
Published: August 2023

Not available
Clinical and Lifestyle Determinants of Continuous Glucose Monitoring Metrics in Insulin-Treated Patients with Type 2 Diabetes Mellitus
Authors: Lee Da Young , Kim Namho , Jung Inha , Park So Young , Yu Ji Hee , Seo Ji A , Kim Jihee , Kim Kyeong Jin , Kim Nam Hoon , Yoo Hye Jin , Kim Sin Gon , Choi Kyung Mook , Baik Sei Hyun , Park Sung-Min , Kim Nan Hee
Published: August 2023

Background: There was limited evidence to evaluate the association between lifestyle habits and continuous glucose monitoring (CGM) metrics. Thus, we aimed to depict the behavioral and metabolic determinants of CGM metrics in insulin-treated patients with type 2 diabetes mellitus (T2DM).Methods: This is a prospective observational study. We analyzed data from 122 insulin-treated patients with T2DM. Participants wore Dexcom G6 and Fitbit, and diet information was identified for 10 days. Multivariate-adjusted logistic regression analysis was performed for the simultaneous achievement of CGM-based targets, defined by the percentage of time in terms of hyper, hypoglycemia and glycemic variability (GV). Intake of macronutrients and fiber, step counts, sleep, postprandial C-peptide-to-glucose ratio (PCGR), information about glucose lowering medications and metabolic factors were added to the analyses. Additionally, we evaluated the impact of the distribution of energy and macronutrient during a day, and snack consumption on CGM metrics.Results: Logistic regression analysis revealed that female, participants with high PCGR, low glycosylated hemoglobin (HbA1c) and daytime step count had a higher probability of achieving all targets based on CGM (odds ratios [95% confidence intervals] which were 0.24 [0.09 to 0.65], 1.34 [1.03 to 1.25], 0.95 [0.9 to 0.99], and 1.15 [1.03 to 1.29], respectively). And participants who ate snacks showed a shorter period of hyperglycemia and less GV compared to those without.Conclusion: We confirmed that residual insulin secretion, daytime step count, HbA1c, and women were the most relevant determinants of adequate glycemic control in insulin-treated patients with T2DM. In addition, individuals with snack consumption were exposed to lower times of hyperglycemia and GV.
Telogen-sparing arthroconidia involvement in an adult case of endothrix tinea capitis
Authors: Starace Michela , Boling Lindsay B. , Bruni Francesca , Lanzoni Anna , Milan Elisa , Pepe Francesca , Piraccini Bianca M. , Misciali Cosimo
Published: August 2023

Tinea capitis is a dermatophyte infection of the scalp that most commonly affects children and is relatively rare in adults. In this case, a 66-year-old Italian woman presented with chronic diffuse papulopustular lesions on the scalp. Personal medical history was positive for itching, repeatedly treated with oral antibiotics without improvement. Trichoscopy observed broken hairs, fine desquamation, signs of scalp inflammation, and folliculitis. A punch biopsy of the scalp revealed a moderately dense mixed inflammatory infiltrate with edema and dilated capillaries. Periodic acid-Schiff stain revealed arthroconidia in the hair shaft and in the inner root sheath of the hair follicle. It was additionally noted that arthroconidia were not present in hair follicles in the telogen phase. The fungal culture subsequently showed Trichophyton tonsurans. Therefore, the patient was diagnosed with an endothrix tinea capitis infection and was treated with oral terbinafine, oral corticosteroids, as well as topical ciclopirox and naftifine creams. Considering the relative lack of specific literature regarding the hair cycle involvement of arthroconidia in endothrix tinea capitis infections and the fact that the sources found cited the presence of arthroconidia in both anagen and telogen phase follicles, we present this case of telogen-sparing arthroconidia involvement in an adult with an endothrix tinea capitis infection.
Impact of tumour rupture risk on the oncological rationale for the surgical treatment choice of gastrointestinal stromal tumours
Authors: Peparini Nadia
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Prevention and treatment of hepatic encephalopathy during the perioperative period of transjugular intrahepatic portosystemic shunt
Authors: Wang Lan-Jing , Yao Xin , Qi Qi , Qin Jian-Ping
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma
Authors: Zheng Lin-Lin , Wang Ya-Ru , Liu Zhen-Rong , Wang Zhi-Hao , Tao Chang-Cheng , Xiao Yong-Gang , Zhang Kai , Wu An-Ke , Li Hai-Yang , Wu Jian-Xiong , Xiao Ting , Rong Wei-Qi
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Long-term survival of patients with hepatocellular carcinoma with hepatic, pulmonary, peritoneal and rare colon metastasis: A case report
Authors: Gong Yong-Qiang , Lu Tai-Liang , Chen Chao-Wu
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Outpatient hybrid endoscopic submucosal dissection with SOUTEN for early gastric cancer, followed by endoscopic suturing of the mucosal defect: A case report
Authors: Ito Renma , Miwa Kazuhiro , Matano Yutaka
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Is endoscopic mucosal resection-precutting superior to conventional methods for removing sessile colorectal polyps?
Authors: Yang Qun-Ying , Zhao Qian , Hu Jian-Wen
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Recursos tecnológicos nas aulas de produção textual
Authors: Fabiano Campos Sulemi , Araújo Cassiano Ionara
Published: August 2023

Resumo: O trabalho busca refletir sobre os desafios para o ensino da produção textual(COELHO; PALOMANES, 2019), as atribuições do professor de língua portuguesa e ascontribuições que as Tecnologias Digitais da informação e Comunicação (TDIC) podemoferecer para a prática de escrita (COSCARELLI, 2016). Para tanto, o artigo apresentaalgumas considerações sobre a importância e funcionalidades da escrita (ANTUNES,2003; CABRAL, 2018, 2019); aponta ferramentas digitais que podem auxiliar noprocesso de ensino e aprendizagem da produção textual e sistematiza atividades quepodem ser desenvolvidas com o uso das ferramentas digitais apontadas. A pesquisa sedivide em duas partes: uma consiste em leitura bibliográfica e a segunda apresenta umaproposta de ensino da escrita, em que são utilizadas Tecnologias Digitais de Informaçãoe Comunicação. As proposições de atividades apresentadas neste material objetivam darsuporte aos professores que atuam no ensino da produção textual.
Significados das Relações Interpessoais Para a Enfermagem no Contexto da Assistência Hospitalar
Authors: Silveira Lima Ana Laura , Gonçalves Barbosa Tayna , Martins Silva Yan Lucas , Veloso Dias Orlene , Andrade Barbosa Henrique , Andrade Sampaio Cristina , Vieira Maria Aparecida
Published: August 2023

Objetivo: Compreender os significados do relacionamento interpessoal atribuídos por profissionais e estudantes da área da enfermagem na dinâmica do seu ambiente de trabalho, tendo como referencial teórico o Interacionismo Simbólico. Método: Estudo exploratório, com abordagem qualitativa, com 10 integrantes da área da Enfermagem. A coleta das informações ocorreu mediante entrevista semiestruturada e a análise pela técnica de análise de conteúdo, utilizando-se o software ATLAS.ti. Resultados: Foram identificados os significados relativos ao relacionamento interpessoal da equipe de enfermagem no contexto hospitalar, bem como aspectos facilitadores e dificultadores. Apesar do destaque dado às fragilidades, as participantes reconheceram fatores favorecedores do trabalho em equipe, como bom relacionamento interpessoal, comunicação e reconhecimento pelo trabalho realizado. Considerações finais: É necessário enfocar a comunicação no processo de trabalho da enfermagem, enfatizar os relacionamentos interpessoais, seus significados e a subjetividade, possibilitando a construção de objetivos comuns entre a equipe, a fim de garantir a promoção da assistência completa.
Analysis of the Effect of Organizational Climate, Work Motivation, and Job Satisfaction on Lecturer Performance at Medan State Polytechnic
Authors: Ginting Hartono , Sinambela Martolop , Sibarani Pirma , Haro Jamardua , Ginting Jasa
Published: August 2023

The human qualities needed by the Indonesian nation in the future are humans who are able to compete with other countries. Obtaining quality human beings will be produced through the implementation of quality education. This study aims to determine the effect of organizational climate, work motivation and job satisfaction on the performance of lecturers at the Medan State Polytechnic. The population includes all lecturers who have civil servant status, totaling 310 people with a sample of 76 people taken by proportionate random sampling. Data was collected by using interview techniques, questionnaires and documentation studies. The data analysis technique uses Multiple Regression analysis so that it can be seen the influence of organizational climate, work motivation and job satisfaction on lecturer performance either partially or simultaneously. The results of the research show that simultaneously organizational climate, work motivation and job satisfaction have a positive and significant effect on lecturer performance. Partially, organizational climate and work motivation have a positive and significant effect on lecturer performance, while job satisfaction has a positive and insignificant effect on lecturer performance.
DO THE DISPERSION PROPERTIES OF ELECTROMAGNETIC SURFACE WAVES AT THE SHARP BOUNDARY PLASMA-METAL IN SLAB VOIGT GEOMETRY REPRESENT THE LIMITING CASE OF THOSE FOR THE INTERFACE OF TWO PLASMAS?
Authors: Girka I.O. , Thumm Manfred
Published: August 2023

Electromagnetic surface waves in Voigt geometry are considered to resolve the contradiction between two classical studies. One investigated the waves at the boundary of two plasmas. These waves were reported not to propagate with frequencies below the ion cyclotron frequency. The other approach studied the waves at the metal-plasma
interface. Dispersion properties of the waves with frequencies below the ion cyclotron frequency were investigated.
An Investigation on the Evaluation of Antecedents Affecting Brand Loyalty: A Mediated-Moderated Approach
Authors: Yaqub Rana Muhammad Shahid , Ahmed Najeeb , Ali Muhammad Qasim , Ashraf Faiza
Published: August 2023

This research studied the importance of brand love, its antecedents and consequences in the context of Smartphone industry; and examined the effects of each dimension of consumer characteristics, brand relationship attributes, and brand experience on brand love. The study also investigated the moderating role of self-esteem between brand love and brand loyalty relationship. The data was collected from the 351 students (users of Smartphone) from four universities of Islamabad, Lahore and Bahawalpur, through simple random sampling. Hypotheses were tested by using regression analysis. The result of the study indicated that each dimension of consumer characteristics, brand relationship attributes and brand experience positively and significantly affected brand love. The findings of this study revealed that brand relationship attributes, brand identity, brand image and brand experience contributed in generating brand love and brand loyalty. The study also found that consumer characterises and brand trust did not create brand love and brand loyalty. This study contributed in literature by examining brand love as a mediator and self-esteem as a moderator. Brand experience was found as the stronger antecedent of brand love. The finding of the study provided several useful managerial implications for strategy formulation at organization level.
DÜNDEN BUGÜNE FEDERAL ALMANYA ANAYASASI VE UYGULAMASINDA SİYASİ PARTİLERE YÖNELİK YAPTIRIMLAR
Authors: AKÇA Kürşat
Published: August 2023

Federal Almanya Anayasası’nda siyasi partilere yönelik olarak siyasi partilerin kapatılması ve siyasi partilerin devlet finansmanından mahrum bırakılması şeklinde iki türlü yaptırım bulunmaktadır. Bunlardan siyasi partilerin kapatılması yaptırımı, Anayasa’nın yürürlüğe girdiği 1949 yılından bu yana Anayasa’da yer almaktadır. Ancak söz konusu yaptırımın uygulaması çok fazla olmamış sadece iki kez parti kapatma kararı verilmiştir. Buna rağmen partilerin kapatılması yaptırımı, Federal Almanya’da sıklıkla gündeme gelmektedir. Nitekim 2017 yılında Federal Alman Anayasa Mahkemesi partilerin kapatılması yaptırımına ilişkin önemli bir karar vermiştir. Söz konusu kararla birlikte Mahkeme, partilerin kapatılabilmesi için belirli bir potansiyele sahip olması şartını aramıştır. Böylece demokratik düzene karşı olup da bu düzene zarar verme potansiyeli olmayan partilerin kapatılması ihtimali devre dışı bırakılmıştır. Bununla birlikte demokratik düzene karşı olup da potansiyeli olmadığı gerekçesiyle kapatılmayan partilere yönelik olarak 2017 yılında diğer bir siyasi parti yaptırımı olan devlet finansmanından yoksun bırakma yaptırımı anayasaya eklenmiştir. Çalışmada her iki yaptırım, Federal Alman Anayasa Mahkemesi’nin kararları ışığında inceleme konusu yapılmıştır.
ADAPTAÇÃO DE TEXTOS LITERÁRIOS PARA O CINEMA
Authors: Gomes de Almeida Alcione
Published: August 2023

O propósito deste artigo é apresentar uma reflexão acerca da adaptação de textos literários para o cinema, cuja origem remonta a uma pesquisa maior que se encontra em desenvolvimento e trata a questão no âmbito da filmografia de textos literários do autor Plínio Marcos, realizada em diferentes décadas. As ideias desenvolvidas se embasam em teóricos tradicionais que incluíram o universo cinematográfico em seus interesses de pesquisa, tendo muito contribuído com a sistematização e evolução dos estudos da construção fílmica, a exemplo de Randal Johnson (1982, 2003) e Robert Stam (2006, 2013).
A IMPORTÂNCIA DA ESCOLA NO PROCESSO INCLUSIVO DE CRIANÇAS AUTISTAS
Authors: Caparroz Joelma , Soldera Paulo Eduardo dos Santos
Published: August 2023

A pesquisa teve como objetivo geral analisar a importância da escola no processo inclusivo de crianças com autismo. Foi possível identificar a relevância para aquisição de habilidades comunicativas e de que forma as intervenções encontradas no âmbito escolar representam elementos importantes para melhor prognóstico e desenvolvimento da criança autista. Os resultados mostraram que a inclusão educacional de crianças autistas representa uma fatia da inclusão social desses indivíduos. É importante haver parceria entre escola e família, pois os pais são portadores de informações valiosas que colaboram com o planejamento de intervenções educacionais. As estratégias educacionais desenvolvidas no âmbito escolar devem ter continuidade dentro de casa, para isso, conclui-se que as propostas pedagógicas e a compreensão do indivíduo com autismo são um trabalho paralelo com os familiares e as intervenções promovem efeitos recíprocos.
PESQUISA BIBLIOGRÁFICA ACERCA DO HUMOR, DO RISO E DA COMICIDADE VOLTADA PARA O ENSINO DE LÍNGUAS
Authors: Vasconcelos Silvia Ines Coneglian Carrilho de , Käfer Erica de Lima
Published: August 2023

Humor, comicidade e riso são três conceitos que têm emergido em algumas pesquisas ou publicações com foco no ensino em geral. Embora haja publicações que indicam o uso do humor como fator positivo nas relações humanas e na recuperação de sujeitos enfermos, ainda há resistência, nas práticas de ensino, em fazer circular atividades que contemplem o humor ou o cômico ou ainda aquelas que provoquem riso em sala de aula. Nos materiais didáticos a presença de tais atividades é rara. A partir dessa constatação, foi realizado um levantamento em publicações referentes ao ensino de línguas entre 2010 e 2021 em bases de dados como Google Acadêmico, Directory of Open Access Journals (DOAJ) e a Scientific Electronic Library Online (SciELO). Os resultados mais evidentes apontam os seguintes números: Português língua estrangeira (3 documentos); Inglês língua estrangeira (4 documentos); Português língua materna (8 documentos), publicados em teses, artigos e capítulos de livro. Esses dados evidenciam, em face do volume de publicações relativas ao ensino de línguas presentes nas bases acima elencadas, a baixa frequência de pesquisa relativa ao tema central da pesquisa.
Prevention and treatment of diabetic foot
Authors: Valčiukienė Lina , Stauskienė Kristina , Urbonienė Laima
Published: August 2023

People with diabetes often have foot problems. If not prevented, diabetic feet develop wounds, deformities and infections, making treatment lengthy and costly for the healthcare system. Diabetic foot is a fast-growing chronic complication of diabetes and has been diagnosed in more than 400 million people worldwide. More than 85% of affected people have had their lower limbs amputated as a result of this condition.Although health professionals and researchers have paid little attention to effectively addressing this problem compared to treating diabetic foot, preventing diabetic foot is an excellent way to prevent the severe morbidity and mortality of people with diabetes.

The aim of the study is to analyse the prevention and treatment of diabetic foot on the basis of a systematic review of the scientific literature.

Materials and methods. The type of study was a systematic literature review. The systematic literature review was conducted using the PRISMA (Perffered Reporting Item for Systematic Reviews and MetaAnalyses) method. For the systematic literature review, publications were searched for in the virtual electronic databases Pub Med and Google Scholar. The search used terms relevant to the aim of the study (diabetic foot, diabetic foot ulcer, treatment, complications, prevention). Twenty (n=20) full articles meeting the eligibility criteria were included in the systematic review of the scientific literature.