bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of functional microexons by transfer learning
Authors: Cheng Qi , He Bo , Zhao Chengkui , Bi Hongyuan , Chen Duojiao , Han Shuangze , Gao Haikuan , Feng Weixing
Published: November 2021

Background

Microexons are a particular kind of exon of less than 30 nucleotides in length. More than 60% of annotated human microexons were found to have high levels of sequence conservation, suggesting their potential functions. There is thus a need to develop a method for predicting functional microexons.

Results

Given the lack of a publicly available functional label for microexons, we employed a transfer learning skill called Transfer Component Analysis (TCA) to transfer the knowledge obtained from feature mapping for the prediction of functional microexons. To provide reference knowledge, microindels were chosen because of their similarities to microexons. Then, Support Vector Machine (SVM) was used to train a classification model in the newly built feature space for the functional microindels. With the trained model, functional microexons were predicted. We also built a tool based on this model to predict other functional microexons. We then used this tool to predict a total of 19 functional microexons reported in the literature. This approach successfully predicted 16 out of 19 samples, giving accuracy greater than 80%.

Conclusions

In this study, we proposed a method for predicting functional microexons and applied it, with the predictive results being largely consistent with records in the literature.
Laboratory identification and clinical characteristics of Streptococcus bovis/Streptococcus equinus complex bacteremia: a retrospective, multicenter study in Hiroshima, Japan
Authors: Kaiki Yuki , Kitagawa Hiroki , Tadera Kayoko , Taogoshi Hiroyuki , Ikeda Mitsuyasu , Kano Mikihiro , Harino Toshie , Nomura Toshihito , Omori Keitaro , Shigemoto Norifumi , Takahashi Shinya , Ohge Hiroki
Published: November 2021

Background

Bacteremia due to the Streptococcus bovis/Streptococcus equinus complex (SBSEC) is associated with specific diseases, such as colorectal cancer and infective endocarditis. This study aimed to evaluate the clinical characteristics of SBSEC bacteremia and the accuracy of identification of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and phenotypic identification systems for SBSEC isolates.

Methods

We analyzed patients with SBSEC bacteremia retrospectively between 2012 and 2019 at three hospitals in Japan. We re-identified each SBSEC isolate using sequencing superoxide dismutase (sodA) analysis, MALDI-TOF MS using the MALDI Biotyper, and phenotypic identification using the VITEK2.

Results

During the study period, 39 patients with SBSEC bacteremia were identified. S. gallolyticus subsp. pasteurianus (SGSP, n = 29), S. gallolyticus subsp. gallolyticus (SGSG, n = 5), S. lutetiensis (SL, n = 4), and S. infantarius subsp. infantarius (n = 1) were identified using sodA sequencing analysis. Primary bacteremia (36%) was the most common cause of bacteremia, followed by infective endocarditis (26%) and biliary tract infections (23%). Colorectal cancer was associated significantly with SGSG bacteremia, while the sources of bacteremia were similar in each SBSEC subspecies. The MALDI Biotyper was significantly more accurate in identifying the SBSEC isolates at the subspecies level compared to the VITEK2 (92% vs. 67%, P = 0.010). In contrast, there were no significant differences in the rates of correct identification of the SBSEC isolates at the species level between the MALDI Biotyper and the VITEK2 (100% vs. 87%, P = 0.055).

Conclusions

Bacteremia with SGSG was associated with colorectal cancer, and the sources of bacteremia were similar in each SBSEC subspecies. The MALDI-TOF MS was significantly more accurate in identifying SBSEC isolates at the subspecies level than the phenotypic identification systems. The accurate identification of SBSEC isolates using the MALDI-TOF MS and phenotypic identification systems was sufficient at the species level, but it was insufficient at the subspecies level. Therefore, it may be reasonable for clinicians to perform echocardiographies and colonoscopies in all patients with SBSEC bacteremia.
Hypospadias: clinical approach, surgical technique and long-term outcome
Authors: Ceccarelli Pier Luca , Lucaccioni Laura , Poluzzi Francesca , Bianchini Anastasia , Biondini Diego , Iughetti Lorenzo , Predieri Barbara
Published: November 2021

Background

Hypospadias is one of the most common congenital abnormalities in male newborn. There is no universal approach to hypospadias surgical repair, with more than 300 corrective procedures described in current literature. The reoperation rate within 6–12 months of the initial surgery is most frequently used as an outcome measure. These short-term outcomes may not reflect those encountered in adolescence and adult life. This study aims to identify the long-term cosmetic, functional and psychosexual outcomes.

Methods

Medical records of boys who had undergone surgical repair of hypospadias by a single surgical team led by the same surgeon at a single centre between August 2001 and December 2017 were reviewed. Families were contacted by telephone and invited to participate. Surgical outcome was assessed by combination of clinical examination, a life-related interview and 3 validated questionnaires (the Penile Perception Score-PPS, the Hypospadias Objective Score Evaluation-HOSE, the International Index of Erectile Function-5-IIEF5). Outcomes were compared according to age, severity of hypospadias, and respondent (child, parent and surgeon).

Results

187 children and their families agreed to participate in the study. 46 patients (24.6%) presented at least one complication after the repair, with a median elapsed time of 11.5 months (6.5–22.5). Longitudinal differences in surgical corrective procedures (p < 0.01), clinical approach (p < 0.01), hospitalisation after surgery (p < 0.01) were found. Cosmetic data from the PPS were similar among children and parents, with no significant differences in child’s age or the type of hypospadias: 83% of children and 87% of parents were satisfied with the cosmetic result. A significant difference in functional outcome related to the type of hypospadias was reflected responses to HOSE amongst all groups of respondents: children (p < 0.001), parents (p=0.02) and surgeon (p < 0.01). The child’s HOSE total score was consistently lower than the surgeon (p < 0.01). The HOSE satisfaction rate on functional outcome was 89% for child and 92% for parent respondents.

Conclusion

Surgeons and clinicians should be cognizant of the long-term outcomes following hypospadias surgical repair and this should be reflected in a demand for a standardised approach to repair and follow-up.
Targeting screening and treatment for latent tuberculosis infection towards asylum seekers from high-incidence countries – a model-based cost-effectiveness analysis
Authors: Marx Florian M. , Hauer Barbara , Menzies Nicolas A. , Haas Walter , Perumal Nita
Published: November 2021

Background

Enhancing tuberculosis (TB) prevention and care in a post-COVID-19-pandemic phase will be essential to ensure progress towards global TB elimination. In low-burden countries, asylum seekers constitute an important high-risk group. TB frequently arises post-immigration due to the reactivation of latent TB infection (LTBI). Upon-entry screening for LTBI and TB preventive treatment (TPT) are considered worthwhile if targeted to asylum seekers from high-incidence countries who usually present with higher rates of LTBI. However, there is insufficient knowledge about optimal incidence thresholds above which introduction could be cost-effective. We aimed to estimate, among asylum seekers in Germany, the health impact and costs of upon-entry LTBI screening/TPT introduced at different thresholds of country-of-origin TB incidence.

Methods

We sampled hypothetical cohorts of 30–45 thousand asylum seekers aged 15 to 34 years expected to arrive in Germany in 2022 from cohorts of first-time applicants observed in 2017–2019. We modelled LTBI prevalence as a function of country-of-origin TB incidence fitted to data from observational studies. We then used a probabilistic decision-analytic model to estimate health-system costs and quality-adjusted life years (QALYs) under interferon gamma release assay (IGRA)-based screening for LTBI and rifampicin-based TPT (daily, 4 months). Incremental cost-effectiveness ratios (ICERs) were calculated for scenarios of introducing LTBI screening/TPT at different incidence thresholds.

Results

We estimated that among 15- to 34-year-old asylum seekers arriving in Germany in 2022, 17.5% (95% uncertainty interval: 14.2–21.6%) will be latently infected. Introducing LTBI screening/TPT above 250 per 100,000 country-of-origin TB incidence would gain 7.3 (2.7–14.8) QALYs at a cost of €51,000 (€18,000–€114,100) per QALY. Lowering the threshold to ≥200 would cost an incremental €53,300 (€19,100–€122,500) per additional QALY gained relative to the ≥250 threshold scenario; ICERs for the ≥150 and ≥ 100 thresholds were €55,900 (€20,200–€128,200) and €62,000 (€23,200–€142,000), respectively, using the next higher threshold as a reference, and considerably higher at thresholds below 100.

Conclusions

LTBI screening and TPT among 15- to 34-year-old asylum seekers arriving in Germany could produce health benefits at reasonable additional cost (with respect to international benchmarks) if introduced at incidence thresholds ≥100. Empirical trials are needed to investigate the feasibility and effectiveness of this approach.
The estimated effect of graphic warning labels on smoker’s intention to quit in Shanghai, China: a cross-sectional study
Authors: Wang Ruiping , Qiang Yan , Zhu Yan , Gao Xiangjin , Yang Qiong , Li Bin
Published: November 2021

Background

Tobacco consumption is the leading cause of death worldwide. Overwhelming studies demonstrate graphic warning labels (GWLs) on cigarette packs are effective in eliciting negative response to tobacco smoking, modifying beliefs about tobacco dangers, and increasing reported intention to quit, but the estimated effect of GWLs on smoking cessation intention among smokers is still limited in China. In this study, we aim to understand the smoking intensity, smoking duration and smoking cessation intention among current smokers, and to explore how their smoking cessation intention would be influenced by the GWLs in Shanghai.

Methods

From January to June 2021, we totally recruited 1104 current smokers in Songjiang district and Fengxian district of Shanghai by multistage sampling design. We used Android pad assisted electronic questionnaire for data collection, and then implemented logistic regression for odds ratio (OR) and 95% confidence interval (CI) calculation to explore how smoking cessation intention would be influenced by the GWLs among current smokers.

Results

One thousand one hundred four current smokers included 914 males (82.79%), with an average age of 43.61 years. 58.06% of current smokers reported smoking cessation intention due to GWLs. Logistic regression indicated a higher percentage of smoking cessation intention due to GWLs was among female smokers [OR = 2.41, 95% CI (1.61–3.59)], smokers with smoking intensity < 20 cigarette/day [OR = 1.92, 95% CI (1.44–2.55)], smokers with tobacco burden < 20% [OR = 1.94, 95% CI (1.35–2.79)], and among smokers had plan to quit in a year [OR = 6.58, 95% CI (4.71–9.18). Smokers with higher individual monthly income had lower percentage of smoking cessation intention (OR were 0.35, 0.46 and 0.41). Meanwhile, among 642 current smokers without plan to quit in a year, approximately 40% of them reported smoking cessation intention due to GWLs.

Conclusions

Smoking cessation intention due to the assumed GWLs on cigarette packs is high among current smokers in Shanghai, especially in female smokers, smokers with light tobacco burden and mild nicotine dependence. Incorporating smoking intensity as well as smoking burden into the implementation of GWLs as tobacco control measures would discourage smoking in China.
Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model
Authors: Wang Jingru , Gao Shengnan , Zhang Jingyuan , Li Chunxiao , Li Hongwen , Lin Jiangtao
Published: November 2021

Background

Allergic asthma is a chronic airway inflammatory disease with a number of cytokines participating in its pathogenesis and progress. Interleukin (IL)-22, which is derived from lymphocytes, acts on epithelial cells and play a role in the chronic airway inflammation. However, the actual role of IL-22 in allergic asthma is still unclear. Therefore, we explored the effect of IL-22 on allergic airway inflammation and airway hyperresponsiveness (AHR) in an ovalbumin (OVA)-induced asthma mouse model.

Methods

To evaluate the effect of IL-22 in an allergic asthma model, BALB/c mice were sensitized and challenged with OVA; then the recombinant mouse IL-22 was administered intranasally 24 h prior to each challenge. The IL-22 levels in lung homogenates and bronchoalveolar lavage fluid (BALF) were measured by enzyme linked immunosorbent assay, respectively. AHR was evaluated through indicators including airways resistance (Rrs), elastance (Ers) and compliance (Crs); the inflammatory cell infiltration was assessed by quantification of differential cells counts in BALF and lung tissues stained by hematoxylin and eosin (H&E); IL-22 specific receptors were determined by immunohistochemistry staining.

Results

The concentration of IL-22 was significantly elevated in the OVA-induced mice compared with the control mice in lung homogenates and BALF. In the OVA-induced mouse model, IL-22 administration could significantly attenuate AHR, including Rrs, Ers and Crs, decrease the proportion of eosinophils in BALF and reduce inflammatory cell infiltration around bronchi and their concomitant vessels, compared with the OVA-induced group. In addition, the expression of IL-22RA1 and IL-10RB in the lung tissues of OVA-induced mice was significantly increased compared with the control mice, while it was dramatically decreased after the treatment with IL-22, but not completely attenuated in the IL-22-treated mice when compared with the control mice.

Conclusion

Interleukin-22 could play a protective role in an OVA-induced asthma model, by suppressing the inflammatory cell infiltration around bronchi and their concomitant vessels and airway hyperresponsiveness, which might associate with the expression of its heterodimer receptors. Thus, IL-22 administration might be an effective strategy to attenuate allergic airway inflammation.
Surgical correction for adult spinal deformity increases acetabular lateral coverage of femoral heads
Authors: Luo Qiang , Kim Yong-Chan , Kim Ki-Tack , Ha Kee-Yong , Chun Young-Soo , Ahn Joonghyun , Kim Sung-Min , Min Kyeonguk
Published: November 2021

Background

Studies explaining the relationship between hip and spine reported that spinal corrective surgery affected acetabular orientation and changes in pelvic tilt were capable of influencing radiographic measures of acetabular coverage. This study aimed to assess the change in coronal parameters for acetabular coverage as a result of adult spinal deformity (ASD) correction and to analyze the relationship between the postoperative changes in sagittal spinopelvic parameters and coronal acetabular coverage parameters.

Methods

Fifty-two consecutive patients who had undergone multilevel spinal surgical correction were enrolled and evaluated. Coronal acetabular coverage parameters included Tönnis angle (TA), lateral center edge angle (LCEA), and the angle of Sharp (SA). All radiographic parameters were evaluated at the preoperative and the postoperative 1 year. Paired t test was used to determine whether there were significant changes between the time points. Bivariate correlation and linear regression analysis were used to assess the relationship between the postoperative changes of spinal alignment and acetabular orientation.

Results

The surgical correction resulted in significant decrease of TA, increase of LCEA and SA, respectively (p < 0.001). The changes in pelvic tilt (PT) demonstrated weak correlation on TA (β = 0.117, p < 0.001 for right; β = 0.111, p < 0.001 for left).

Conclusions

Although the surgical correction of ASD significantly changed PT resulting in increased acetabular lateral coverage parameters, the correlation between the changes of PT following sagittal correction of ASD and acetabular coverage parameters was low.

Trial registration

This study was retrospectively registered with approval by the institutional review board (IRB) of our institution (approval number: KHNMC-2020-10-010).
Mid-term results of a new femoral prosthesis using Ti-Nb-Sn alloy with low Young’s modulus
Authors: Chiba Daisuke , Yamada Norikazu , Mori Yu , Oyama Masamizu , Ohtsu Susumu , Kuwahara Yoshiyuki , Baba Kazuyoshi , Tanaka Hidetatsu , Aizawa Toshimi , Hanada Shuji , Itoi Eiji
Published: November 2021

Background

This study was performed to investigate the mid-term results of Ti-Nb-Sn (TNS) alloy stem with a low Young’s modulus.

Methods

This study was a multicenter prospective cohort study. A total of 40 primary total hip arthroplasties performed between April 2016 and September 2017 was enrolled in this study. With the unique functional gradient properties by heating treatment, the strength of the proximal portion was enhanced, while the distal portion maintained a low Young’s modulus. The surgeries were performed through the posterolateral approach using the TNS alloy stems. Radiographs were taken from immediately after surgeries until 3 years, and stress shielding and subsidence of the stems were evaluated. The incidences of the stem breakage were also assessed. Clinical assessments were performed using Japanese Orthopaedic Association (JOA) and Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) scores.

Results

Among the 40 enrolled patients, 36 patients were female and 4 were male. At 3 years after surgery, there were no radiologic signs of loosening, subsidence, or breakage of the stem. Stress shielding was observed in 26 hips (65%). Of 26 hips, 16 hips (40%) were grade 1 and 10 hips (25%) were grade 2. There was no advanced stress shielding. The JOA and JHEQ scores significantly improved compared with the preoperative scores.

Conclusion

The current study using a new TNS alloy femoral stem showed good clinical outcomes at 3-year follow-up. Radiologically, there was no loosening or subsidence of the stem. The mild stress shielding was observed in 65% of patients.

Trial registration

Current Controlled TrialsISRCTN21241251.

The date of registration was October 26, 2021.

Retrospectively registered.
Exploration of the experiences of working stressors and coping strategies associated with menstrual symptoms among nurses with shifting schedules: a Q methodology investigation
Authors: Yu Shu-Chuan , Hsu Hsiao-Pei , Guo Jong-Long , Chen Shu-Fen , Huang Shu-He , Chen Yin-Chen , Huang Chiu-Mieh
Published: November 2021

Background

The essence and workload of nursing can easily lead to burdens associated with female nurses’ menstrual symptoms, and consequently, result in decreased working performance. Without effective support this can lead to resignation due to maladaptation. This study adopted Q methodology to explore the experience of working stressors and coping strategies associated with menstrual symptoms among nurses with shifting schedules.

Methods

Data were collected in two stages. First, in-depth interviews were conducted to collect nurses’ experiences. Sentences that best fit the study’s purpose were extracted for the construction of Q statements. Second, nurses were allowed to subjectively rank these Q statements by using Q-sorts. A total of 90 participants ranked the designed Q statements. The Q factor analysis revealed a five-factor solution that accounted for 48.90% of the total variance.

Results

The five evident factors included: menstrual symptoms interfering in collaboration with colleagues, deficiency of professional function and stress due to symptoms burden, diverse experiences without a clear pattern, adapted self-management with and without medication use, and stress due to symptoms burden and using medication for self-management.

Conclusions

The identification of these five groups may facilitate the development of responsive strategies to meet nurses’ preferences. Furthermore, identifying workplace factors that are associated with the adverse effects of menstrual symptoms on nurses will be helpful for nursing supervisors and hospital managers. Additionally, strategies that can be implemented to create supportive work environments are discussed.
Dietary carbohydrate quality and risk of breast cancer among women
Authors: Sasanfar Bahareh , Toorang Fatemeh , Mohebbi Elham , Zendehdel Kazem , Azadbakht Leila
Published: November 2021

Background

A few studies have examined the relationship between carbohydrate quality index (CQI) and risk of breast cancer (BC) among women in Middle Eastern countries. We studied the associations between carbohydrate quality index and the risk of BC in overall and by menopausal status.

Methods

In this case-control study, dietary intake of 461 women with pathologically confirmed BC within the past year were examined. The same information were collected for 495 apparently healthy controls using a 168-item validated FFQ. Carbohydrate quality was determined by considering four criteria including: ratio of solid carbohydrates to total carbohydrates, dietary fiber intake, GI and the ratio of whole grains to total grains.

Results

Mean GI and GL of participants were totally 57.5 ± 7.2 and 245.7 ± 64.7, respectively. A trend toward significant association was seen between GI and odds of BC in the whole population; such that after stratifying analysis by menopausal status, premenopausal women in the highest quartile of GI were 1.85 times higher likely to have BC than those in the lowest quartile (95% CI: 1.12, 3.07, P = 0.01). We found that women with the greatest CQI had lower odds for BC, compared with those with the lowest CQI (0.63; 95% CI: 0.43–0.94, P = 0.03). This association was remained after stratifying analysis by menopausal status in premenopausal (0.55; 95% CI: 0.34–0.90, P = 0.04).

Conclusion

We found that GI was directly and CQI inversely associated with odds of BC. In order to determine the effects of dietary carbohydrate quality prospective cohort studies are needed.
A method for obtaining field wheat freezing injury phenotype based on RGB camera and software control
Authors: Fu Xiuqing , Bai Yang , Zhou Jing , Zhang Hongwen , Xian Jieyu
Published: November 2021

Background

Low temperature freezing stress has adverse effects on wheat seedling growth and final yield. The traditional method to evaluate the wheat injury caused by the freezing stress is by visual observations, which is time-consuming and laborious. Therefore, a more efficient and accurate method for freezing damage identification is urgently needed.

Results

A high-throughput phenotyping system was developed in this paper, namely, RGB freezing injury system, to effectively and efficiently quantify the wheat freezing injury in the field environments. The system is able to automatically collect, processing, and analyze the wheat images collected using a mobile phenotype cabin in the field conditions. A data management system was also developed to store and manage the original images and the calculated phenotypic data in the system. In this experiment, a total of 128 wheat varieties were planted, three nitrogen concentrations were applied and two biological and technical replicates were performed. And wheat canopy images were collected at the seedling pulling stage and three image features were extracted for each wheat samples, including ExG, ExR and ExV. We compared different test parameters and found that the coverage had a greater impact on freezing injury. Therefore, we preliminarily divided four grades of freezing injury according to the test results to evaluate the freezing injury of different varieties of wheat at the seedling stage.

Conclusions

The automatic phenotypic analysis method of freezing injury provides an alternative solution for high-throughput freezing damage analysis of field crops and it can be used to quantify freezing stress and has guiding significance for accelerating the selection of wheat excellent frost resistance genotypes.
New inequalities for weaving frames in Hilbert spaces
Authors: Xu Yuxiang , Leng Jinsong
Published: November 2021

In this paper, we establish Parseval identities and surprising new inequalities for weaving frames in Hilbert spaces which involve scalar $\lambda \in {\mathcal{R}}$
λ
∈
R
. With suitable choices of λ, one obtains the previous results as special cases. Our results generalize and improve the remarkable results obtained by Balan et al. and Găvruţa.
A separated representation involving multiple time scales within the Proper Generalized Decomposition framework
Authors: Pasquale Angelo , Ammar Amine , Falcó Antonio , Perotto Simona , Cueto Elías , Duval Jean-Louis , Chinesta Francisco
Published: November 2021

Solutions of partial differential equations can exhibit multiple time scales. Standard discretization techniques are constrained to capture the finest scale to accurately predict the response of the system. In this paper, we provide an alternative route to circumvent prohibitive meshes arising from the necessity of capturing fine-scale behaviors. The proposed methodology is based on a time-separated representation within the standard Proper Generalized Decomposition, where the time coordinate is transformed into a multi-dimensional time through new separated coordinates, each representing one scale, while continuity is ensured in the scale coupling. For instance, when considering two different time scales, the governing Partial Differential Equation is commuted into a nonlinear system that iterates between the so-called microtime and macrotime, so that the time coordinate can be viewed as a 2D time. The macroscale effects are taken into account by means of a finite element-based macro-discretization, whereas the microscale effects are handled with unidimensional parent spaces that are replicated throughout the time domain. The resulting separated representation allows us a very fine time discretization without impacting the computational efficiency. The proposed formulation is explored and numerically verified on thermal and elastodynamic problems.
Comparative studies on the hypoglycemic and antioxidant activities of Vernonia amygdalina delile and Baccharoides tenoreana olive in alloxan-induced hyperglycemic rats
Authors: Attama Samuel Chijioke , Aba Patrick Emeka , Asuzu Chinwe Uchechukwu , Asuzu Isaac Uzoma
Published: November 2021

Background

Vernonia amygdalina is a bitter culinary vegetable known to possess anti-diabetic principle. Baccharoides tenoreana belonging to the same species as V. amygdalina, is also used in cooking soup and it is comparatively non-bitter. However, its glycemic properties have not been studied. This study becomes imperative to find out if B. tenoreana possesses hypoglycemic and antioxidant properties and how it compares with V. amygdalina. Should B. tenoreana be better than V. amygdalina, it should be preferable since it is non-bitter and can comfortably be taken compared to V. amygdalina. This study investigated the comparative hypoglycemic and antioxidant potentials of V. amygdalina (VA) and B. tenoreana (BT).

Methods

Thirty male Albino wistar rats assigned into six groups of five rats per group were used for the study. Diabetes was induced in groups B-F rats by a single intraperitoneal injection of alloxan monohydrate at 160 mg/kg. Groups C-E rats were treated with VA (200 mg/kg), BT (200 mg/kg) and combination of VA & BT (100 mg/kg each) respectively. Group F rats were administered glibenclamide (2 mg/kg) whereas groups A and B rats were given distilled water. All treatments were through the oral administration, once daily for 21 consecutive days. Fasting blood glucose (FBG) levels were determined after 1 h, 3 h, 6 h, 24 h, 7 days, 14 days and 21 days while lipid profile, in vivo antioxidant and pancreatic histomorphology were assessed on day 21 post-treatment.

Results

The VA-treated rats recorded marginally reduced FBG, malondialdehyde and low-density lipoprotein levels when compared to the counterpart treated with BT. The high-density lipoprotein values were significantly higher in VA-treated rats than in BT-treated rats. The histomorphology of the pancreas of VA-treated rats expressed more islet cells compared to the counterpart treated with VT.

Conclusion

Both VA and BT exhibited hypoglycemic and antioxidant activities with varying potencies.
Cardiac monitoring in memory clinics: national survey of UK practice
Authors: Crowther George , Ahmed Noura , Kasa Deepa , Goff Zoe , Tayebjee Muzahir H.
Published: November 2021

Aims and method

People diagnosed with dementia are often started on acetylcholinesterase inhibitors (AChEIs). As AChEIs can be associated with cardiac side-effects, an electrocardiogram (ECG) is sometimes requested before treatment. Previous work has suggested there is little consensus as to when or how ECGs should be obtained. This can create inconsistent practice, with patient safety, economic and practical repercussions. We surveyed 305 UK memory clinic practitioners about prescribing practice.

Results

More than 84% of respondents completed a pulse and cardiac history before prescribing AChEIs. Opinion was divided as to who should fund and conduct ECGs. It was believed that obtaining an ECG causes patients inconvenience and delays treatment. Despite regularly interpreting ECGs, 76% of respondents did not update this clinical skill regularly.

Clinical implications

The variation in practice observed has service-level and patient implications and raises potential patient safety concerns. Implementing national guidelines or seeking novel ways of conducting cardiac monitoring could help standardise practice.
MRI-based radiomics model can improve the predictive performance of postlaminar optic nerve invasion in retinoblastoma
Authors: Li Zhenzhen , Guo Jian , Xu Xiaolin , Wei Wenbin , Xian Junfang
Published: November 2021

Objectives:

To develop an MRI-based radiomics model to predict postlaminar optic nerve invasion (PLONI) in retinoblastoma (RB) and compare its predictive performance with subjective radiologists’ assessment.

Methods:

We retrospectively enrolled 124 patients with pathologically proven RB (90 in training set and 34 in validation set) who had MRI scans before surgery. A radiomics model for predicting PLONI was developed by extracting quantitative imaging features from axial T2W images and contrast-enhanced T1W images in the training set. The Kruskal–Wallis test, least absolute shrinkage and selection operator regression, and recursive feature elimination were used for feature selection, where upon a radiomics model was built with a logistic regression (LR) classifier. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve and the accuracy were assessed to evaluate the predictive performance in the training and validation set. The performance of the radiomics model was compared to radiologists’ assessment by DeLong test.

Results:

The AUC of the radiomics model for the prediction of PLONI was 0.928 in the training set and 0.841 in the validation set. Radiomics model produced better sensitivity than radiologists’ assessment (81.1% vs  43.2% in training set, 82.4vs 52.9% in validation set). In all 124 patients, the AUC of the radiomics model was 0.897, while that of radiologists’ assessment was 0.674 (p < 0.001, DeLong test).

Conclusion:

MRI-based radiomics model to predict PLONI in RB patients was shown to be superior to visual assessment with improved sensitivity and AUC, and may serve as a potential tool to guide personalized treatment.
An extrahepatic hydatid cyst with the fat-fluid level
Authors: Yildirim Ferhat , Turan Aynur , Guven Selda , Ceylan Arda
Published: November 2021

A hydatic cyst is a zoonosis caused by the larva of a tapeworm Echinococcus granulosus. The liver is the most commonly affected organ. Soft tissue localization has been reported in 2.3% of cases. Herein, we present a patient with a fat-containing hydatid cyst located in the left thigh. There are only a few reports in the literature on the presence of the fat-fluid level within a hydatid cyst. Previous studies have suggested that fat-containing hydatid cysts occur due to their cysto-biliary communication in the liver. In our case, we describe a fat-containing hydatid cyst in the extrahepatic location and discuss the pathophysiologic mechanism of fat inside it.
Bilateral type IIpersistent proatlantal intersegmental artery: a rare variant of persistent carotid-vertebrobasilar anastomoses
Authors: Fang Yajun , Li Shuhua , Zhang Chuanchen
Published: November 2021

The persistent proatlantal intersegmental artery is a rare variant of persistent carotid-vertebrobasilar anastomoses, especially their bilateral presence is rarer. We report a case of bilateral typeII persistent proatlantal intersegmental artery. The absence of bilateral vertebral arteries was incidentally noted on neck ultrasound examination. Subsequent time-of-flight MR angiography confirmed this. The bilateral typeIIpersistent proatlantal intersegmental artery arose from the cervical external carotid artery, penetrated the C1 transverse foramen, entered the skull via the foramen magnum, and joined the lower portion of the basilar artery.
Sclerosing stromal tumor of the ovary: a case series and review of literature
Authors: Mittermair Christof , Cunha Teresa Margarida , Urbas Romana , Koch Horst , Forstner Rosemarie
Published: November 2021

Sclerosing stromal tumor of the ovary is a rare benign sex-cord stromal tumor that affects primarily young females. In a series of six patients (mean 24,6, median 19 years) findings of six MRIs and one CT were analyzed. Unilateral tumors ranging from 6 to 8 cm were found in all patients. The tumors were well encapsulated and polylobulated. The morphology was mixed solid and cystic in three and solid in three patients. In CT, a hypervascular tumor with centripetal enhancement was seen. In MRI T2 weighted imaging showed low signal intensity of the solid tissue in all cases and low diffusion-weighted imaging signal of the solid tissue in high b-value diffusion-weighted imaging in three patients. Contrast enhancement was avid with extension from the periphery in all patients. Knowledge of these distinct radiological features of sclerosing stromal tumor is important, as in the Ovarian-Adnexal Reporting and Data System risk classification system this may be scored as Ovarian-Adnexal Reporting and Data System 5. Because of its non-aggressive clinical course, pre-operative imaging assists to avoid unnecessary extensive surgery and to preserve the patient’s fertility by only resecting the tumor and preserving the ovary. Sclerosing stromal tumor of the ovary presents pathognomonic features in MRI that allow a specific pre-operative diagnosis and selecting candidates for fertility-sparing surgery.
Oesophageal adenocarcinoma metastasis into a microcystic meningioma: a rare occurrence of tumour to tumour metastasis
Authors: Khan Basil Zia , Akinjise-ferdinand Oluwaseun , Kumar Bhaskar
Published: November 2021

A 78-year-old male was admitted with a history of a fall following seizures. This occurred 2 years post-curative treatment (minimally invasive oesophagectomy with neo-adjuvant chemotherapy) for an oesophageal adenocarcinoma staged T3N0M0. On examination, patient had left-sided hemiparesis. A CT and magnetic resonance image (MRI) of the head confirmed a right frontotemporal meningioma with features suggestive of internal haemorrhage or calcification and mild local mass effect. A joint decision was made between the local neuro-surgical and neurology departments to manage this conservatively. However, due to progressive neurological deterioration and a concomitant increase in the size of the haemorrhagic lesion, emergent surgical intervention was indicated. The patient underwent a Simpson one complete resection (complete tumour resection including associated dura matter and abnormal underlying bone). Postoperative histology confirmed a rare case of metastatic oesophageal adenocarcinoma to a microcystic meningioma (World Health Organization Grade I). The meningioma was the only known site of distant metastasis for the oesophageal adenocarcinoma. Our case highlights the only documented case of the adenocarcinoma subtype of oesophageal tumour metastasizing to a meningioma. This case demonstrates the rare but well-documented occurrence of tumour to tumour metastasis. It highlights the importance played by imaging and clinical correlation when assessing progressively growing meningiomas in patients with a history of or underlying malignancy.
Radiology and the medical student: do increased hours of teaching translate to more radiologists?
Authors: Chew Cindy , O'Dwyer Patrick J , Young David
Published: November 2021

Objectives:

The UK has a shortage of Radiologists to meet the increasing demand for radiologic examinations. To encourage more medical students to consider Radiology as a career, increased exposure at undergraduate level has been advocated. The aim of this study was to evaluate if formal Radiology teaching hours at medical school had any association with the number of qualified Radiologists joining the General Medical Council Specialist Register.

Methods:

Total number of doctors joining the GMC Specialist Register as Clinical Radiologists, and those with a primary medical qualifications awarded in Scotland, was obtained from the GMC (2010–2020). Graduate numbers from all four Scottish Medical Schools (2000–2011) were also obtained. Hours of Radiology teaching for medical schools in Scotland were obtained from validated AToMS study.

Results:

Two hundred and twenty three (6.6%) of 3347 Radiologists added to the GMC Specialist Register between 2010 and 2020 received their primary medical qualification (PMQ) from Scottish Universities. The number of Radiologists from Scottish Universities joining the GMC specialist register was 2.6% of the total number of Scottish Medical Graduates. There was no association between the number of hours (Range 1–30) Radiology was taught to medical students and the number that joined the specialist register as Radiologists (p = 0.54 chi square trend).

Conclusion:

Increased exposure to Radiology teaching does not influence medical students’ decision to take up Radiology as a career. While continued Radiology exposure remains important, other strategies are required in both the short and long term to ensure radiology services are maintained without detriment to patients.

Advances in knowledge:

Increased hours of Radiology teaching in medical school was not associated with increased radiologists joining the profession.
Wkład Alfonsa V Wspaniałomyślnego w upowszechnienie katalońskich zwyczajów kulinarnych w Królestwie Neapolu w XV wieku
Authors: Hryszko Rafał
Published: November 2021

Contribution of Alfonso V the Magnanimous to the Popularization of Catalan Culinary Customs in the Kingdom of Napl es in the 15th century

The wars for Naples ended in 1442 with the victory of Alfonso V the Magnanimous, the ruler of the Crown of Aragon (1416–1458). The emergence of foreign authority in southern Italy entailed the transfer of the Catalan culture, language and customs to the area of Italian Mezzogiorno. In this process, Catalan culinary traditions which developed at the end of the fourteenth century also occupied an important place. One of them was a separate sweet snack, referred to by the Catalan term col·lació (collatio in Latin). The organization and celebration of col·lació became an important form of ostentation for the Catalan ruling and financial elites. In this article, the author discusses excerpts from historical sources whose authors include, among others, Antonio Beccadelli, Jordi de Centelles, Vespasiano da Bisticci, Giovanni Pontano, as well as the ambassadors of Barcelona and Portugal and other anonymous authors writing about the times of Alfonso V the Magnanimous. The data provided by these sources clearly indicate that this ruler followed the custom of eating sweet colazione known in Italy at this time and gave it a new meaning at least as early as in the 1440s. Thanks to this ruler of Aragon and new Neapolitan king, the sweet snack became one of the instruments of the ostentation of wealth and prestige for the new rulers of the southern part of Italy and soon after also for other princes and lords of the area.
Potential attack of the common vampire bat (Desmodus rotundus) on nine-banded armadillo (Dasypus novemcinctus) in northern Oaxaca, México
Authors: Ríos-Solís Jesús Alejandro , López-Acosta Juan Carlos , MacSwiney G. M. Cristina
Published: November 2021

El murciélago vampiro común, Desmodus rotundus, es un depredador que de forma obligatoria, se alimenta de sangre de vertebrados de un grupo diverso de presas, pero con preferencia a los mamíferos, tanto nativos como exóticos.  El presente registro documenta la primera depredación potencial de un armadillo de nueve bandas, Dasypus novemcinctus, por D. rotundus en vida silvestre.  La observación se registró en una cámara trampa colocada en un fragmento de crecimiento secundario de un bosque tropical perennifolio en Oaxaca, México.  En una grabación de 10 segundos, observamos a un individuo de D. rotundus acechando y persiguiendo a un individuo de D. novemcinctus que busca alimento en la hojarasca.  La presente observación, junto con otro estudio realizado en Brasil, donde un murciélago vampiro persiguió a un armadillo gigante Priodontes maximus, sugiere que los armadillos podrían ser presas de D. rotundus, pero la interacción es difícil de registrar en vida silvestre.
Confirmation of the presence of Abert’s squirrel (Sciurus aberti) after a century in Sonora, México
Authors: Gallo-Reynoso Juan Pablo , Armenta-Méndez Lucila , Macías-Sánchez Samuel , Van Devender Thomas R. , Ponce-García Gloria , Cabrera-Hernández Víctor Hugo
Published: November 2021

De acuerdo con algunos autores, la ardilla de Abert (Sciurus aberti) se encuentra típicamente en los bosques de pino blanco (Pinus ponderosa), árbol que les proporciona refugio y alimento.  Estos pinos generalmente se distribuyen entre 1,800 y 3,000 m en Wyoming, Colorado, Nuevo México, Arizona y Utah en los Estados Unidos.  Pinus arizonica era formalmente considerada una variedad de P. ponderosa en el norte de Sonora, México.  Los bosques de la Sierra Madre Occidental no son monoespecíficos, los bosques de pino-encino son muy diversos desde Sonora y Chihuahua hasta el sur de Durango en México.  Existen también bosques de coníferas mixtos dominados por abetos (Pseudotsuga spp.), pinabetes (Picea spp.) y piñón (Pinus strobiformis).  Solo hay un registro previo confirmado de la presencia de la ardilla de Abert obtenido en el Alto Río Bavispe, Sonora, colectada por la Expedición Arqueológica de Lumholtz 1890-92, y otro registro sin confirmar de un probable S. aberti en 1938 al norte de Sonora.  Mientras se monitoreaban rastros de mamíferos a pie (registros de huellas) y se ponían cámaras-trampa para su registro, se observó la presencia de S. aberti en la zona de estudio.  Obtuvimos dos registros ocasionales de S. aberti, ambos en un bosque de pino-encino en la Sierra Madre Occidental en Sonora en el límite del pueblo de Mesa Tres Ríos, Sonora y a 9.4 km al suroeste de Mesa Tres Ríos, Sonora. Se encontró a Sciurus aberti en áreas de pino-encino y bosques mixtos de coníferas, presuntamente usadas por las ardillas de Abert para su alimentación y cobertura, demostrando que estas ardillas no dependen estrictamente del pino ponderosa (P. ponderosa) como se ha reportado, sino que dependen del encino y los pinos Arizona (P. arizonica) y Apache (P. engelmannii), que se encuentran ampliamente distribuidos en el Archipiélago Madrense (Región de las Islas del Cielo) y en la porción norte de la Sierra Madre Occidental (SMO).  Estas observaciones confirman la predicción de la presencia de S. aberti, y son una importante adición a la fauna de mamíferos de Sonora.
Effect of leukemia inhibitory factor polymorphism on litter size traits in Thai commercial pig breeds
Authors:   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand, Norseeda Worrarak ,   Center of Excellence on Agricultural Biotechnology: (AG-BIO/PERDO-CHE), Bangkok 10900, Thailand,   Graduate School, Chiang Mai University, Chiang Mai 50200, Thailand, Liu Guisheng ,   Institute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan 430064, China,   Hubei Key Lab for Animal Embryo Engineering and Molecular Breeding, Wuhan 430064, China, Teltathum Tawatchai ,   Mae Hong Son Livestock Research and Breeding Center, Mae Hong Son 58000, Thailand, Sringarm Korawan ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand,   Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai, 50200, Thailand, Naraballobh Watcharapong ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand, Khamlor Trisadee ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand, Mekchay Supamit ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand,   Center of Excellence on Agricultural Biotechnology: (AG-BIO/PERDO-CHE), Bangkok 10900, Thailand,   Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai, 50200, Thailand,   Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Published: November 2021

Leukemia inhibitory factor (LIF) is a crucial candidate gene that impacts on implantation process. In this study, the effects of the porcine LIF polymorphism on litter size traits were elucidated in Thai commercial pig populations. Genotyping of three single nucleotide polymorphisms (SNPs) of the porcine LIF gene was detected in coding and 3ˊ-untranslated regions. The porcine LIF c.*24C>T was segregating in Large White, Landrace, and Large White × Landrace (LW × LR) crossbred sows. No polymorphisms at two non-synonymous SNPs loci (LIF c.28C>A and LIF c.161A>G) were found in this study. The porcine LIF c.*24C>T was significantly associated with the total number born (TNB), the number born alive (NBA), and the number of piglets weaned alive (NWA) traits in Large White and Landrace sows. Moreover, the porcine LIF c.*24C>T was associated with the NBA and NWA traits in LW × LR crossbred sows. The favorable LIF c.*24C allele was positively correlated with the litter size traits. These findings indicated that the polymorphism of the porcine LIF gene was associated with litter size traits and confirms the significance of porcine LIF as a candidate gene for litter size traits in pig breeding. Thus, the porcine LIF gene could be used for improving prolific traits in these Thai commercial pig populations.