bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling Behavior and Vaccine Hesitancy Using Twitter-Derived US Population Sentiment during the COVID-19 Pandemic to Predict Daily Vaccination Inoculations
Authors: Daghriri Talal , Proctor Michael , Matthews Sarah , Bashiri Abdullateef H.
Published: March 2023

The sentiment analysis of social media for predicting behavior during a pandemic is seminal in nature. As an applied contribution, we present sentiment-based regression models for predicting the United States COVID-19 first dose, second dose, and booster daily inoculations from 1 June 2021 to 31 March 2022. The models merge independent variables representing fear of the virus and vaccine hesitancy. Large correlations exceeding 77% and 84% for the first-dose and booster-dose models inspire confidence in the merger of the independent variables. Death count as a traditional measure of fear is a lagging indicator of inoculations, while Twitter-positive and -negative tweets are strong predictors of inoculations. Thus, the use of sentiment analysis for predicting inoculations is strongly supported with administrative events being catalysts for tweets. Non-inclusion in the second-dose regression model of data occurring before the 1 June 2021 timeframe appear to limit the second-dose model results—only achieving a moderate correlation exceeding 53%. Limiting tweet collection to geolocated tweets does not encompass the entire US Twitter population. Nonetheless, results from Kaiser Family Foundation (KFF) surveys appear to generally support the regression factors common to the first-dose and booster-dose regression models and their results.
Deep Mutational Scanning to Predict Escape from Bebtelovimab in SARS-CoV-2 Omicron Subvariants
Authors: Alcantara Mellissa C. , Higuchi Yusuke , Kirita Yuhei , Matoba Satoaki , Hoshino Atsushi
Published: March 2023

The major concern with COVID-19 therapeutic monoclonal antibodies is the loss of efficacy against continuously emerging variants of SARS-CoV-2. To predict antibody efficacy against future Omicron subvariants, we conducted deep mutational scanning (DMS) encompassing all single mutations of the receptor-binding domain of the BA.2 strain utilizing an inverted infection assay with an ACE2-harboring virus and library spike-expressing cells. In the case of bebtelovimab, which preserves neutralization activity against BA.2 and BA.5, a broad range of amino acid substitutions at K444, V445, and G446, and some substitutions at P499 and T500, were indicated to achieve the antibody escape. Among subvariants with current rises in case numbers, BA2.75 with G446S partially evaded neutralization by bebtelovimab, while complete evasion was observed in XBB with V445P and BQ.1 with K444T. This is consistent with the DMS results against BA.2, highlighting the potential of DMS as a predictive tool for antibody escape.
Persistence of a Wild-Type Virulent Aeromonas hydrophila Isolate in Pond Sediments from Commercial Catfish Ponds: A Laboratory Study
Authors: Tuttle James T. , Bruce Timothy J. , Abdelrahman Hisham A. , Roy Luke A. , Butts Ian A. E. , Beck Benjamin H. , Kelly Anita M.
Published: March 2023

Virulent Aeromonas hydrophila (vAh) is a major bacterial pathogen in the U.S. catfish industry and is responsible for large-scale losses within commercial ponds. Administering antibiotic feeds can effectively treat vAh infections, but it is imperative to discern new approaches and better understand the mechanics of infection for this bacterium. As such, the persistence of vAh in pond sediments was determined by conducting laboratory trials using sediment from four commercial catfish ponds. Twelve chambers contained sterilized sediment, vAh isolate ML-09-119, and 8 L of water maintained at 28 °C and were aerated daily. At 1, 2, 4, 6, and 8 days, and every 7th day post-inoculation for 28 days, 1 g of sediment was removed, and vAh colony forming units (CFU) were enumerated on ampicillin dextrin agar. Viable vAh colonies were present in all sediments at all sampling periods. The vAh growth curve peaked (1.33 ± 0.26 × 109 CFU g−1) at 96 h post-inoculation. The population plateaued between days 14 and 28. No correlations were found between CFU g−1 and physiochemical sediment variables. This study validated the ability of vAh to persist within pond sediments in a laboratory setting. Further research on environmental factors influencing vAh survivability and population dynamics in ponds is needed.
Reviews and Syntheses: Promoting the Advancement of Hillslope Hydrology and Stability in Taiwan from the Perspective of Critical Zone Science
Authors: Yang Ya-Sin , Yeh Hsin-Fu , Huang Chia-Chi , Chen Hsin-Yu
Published: March 2023

Owing to active orogenic movement and the monsoon climate, rainfall-induced landslide disasters often occur in Taiwan. Hence, hillslope hydrology and stability have received considerable research attention. However, it remains difficult to accurately estimate the duration and consequences of hillslope instability induced by hillslope hydrology. Research on hillslope hydrology and stability is complicated by spatial heterogeneity, hydrological processes operating at various scales, spatiotemporal evolution, and geomorphological properties. Recent advances in critical zone science have provided an approach to extend geoscience studies. The “deep coupling” concept is essential for integrating physical, chemical, and biological processes on various spatiotemporal scales and for providing a macro and unified framework for evaluating internal properties and processes. Critical zone science and hillslope hydrology and stability both depend on interdisciplinary perspectives and approaches, monitoring strategies, and model analysis of integrating and coupling processes. They both share the characteristics of spatial heterogeneity, continuous evolution, and relevance to ecosystem services. To address the challenges related to hillslope hydrology and stability in Taiwan, we reviewed the progress in, relevance between, and common challenges to hillslope hydrology, stability, and critical zone science. We then presented a process-based integrated monitoring strategy, an interdisciplinary perspective, and a coupling analysis framework and model. The aim of this study was to promote the advancement of research on hillslope stability and hydrology in Taiwan.
Evidence for Groundwater Salinity Origin Based on Hydrogeochemical and Isotopic (2H, 18O, 37Cl, 3H, 13C, 14C) Approaches: Sousse, Eastern Tunisia
Authors: Nefzaoui Farah , Ben Hamouda Mohamed , Carreira Paula , Marques José , Eggenkamp Hans
Published: March 2023

The key processes responsible for the rise in groundwater salinization in the Mio–Pliocene aquifer system of Sousse (Tunisia, eastern coastline) were identified through a multidisciplinary approach based on the use of geochemical, stable (2H, 13C, 18O and 37Cl) and radioactive (3H and 14C) isotope methods. In the study region, the mineralization of groundwaters is related to water–rock interaction ascribed to the dissolution of minerals in evaporite rocks, as well as to saltwater intrusion. Both processes explain the development of groundwaters in which Cl and Na dominantly determine the groundwater quality deterioration state. The isotopic and geochemical signatures of the studied groundwaters are clearly explained by the (i) occurrence of saline basins (sebkhas adjacent to the study region), (ii) type of rocks found below the ground surface, and (iii) cation exchange between clays and groundwaters.
Slowing Down Quick Runoff—A New Approach for the Delineation and Assessment of Critical Points, Contributing Areas, and Proposals of Measures to Reduce Non-Point Water Pollution from Agricultural Land
Authors: Kvítek Tomáš , Zajíček Antonín , Dostál Tomáš , Fučík Petr , Krása Josef , Bauer Miroslav , Jáchymová Barbora , Kulhavý Zbyněk , Pavel Martin
Published: March 2023

Non-point sources of water pollution caused by agricultural crop production are a serious problem in Czechia, at present. This paper describes a new approach for the mutual delineation and assessment of different pollution sources where the critical points method is used to identify the origin of contamination and the source areas. The critical points, i.e., sites presenting the entry of quick surface and drainage runoff into waters, are classified into three (for surface pollution sources using a WaTEM/SEDEM model) or four (subsurface = drainage sources via the catchment-measures need index) categories, respectively. This enabled us to prioritize the most endangered areas at different scales, ranging from the third-order catchments to very small subcatchments, and to design the appropriate combination of control measures to mitigate surface and drainage water runoff, with these being the main drivers of associated pollution. This methodology was applied to a study conducted in the Czech Republic within the entire Vltava River basin, with a total area of 27,578 km2, and utilized in depth to assess a 543 km2 catchment of the Vlašimská Blanice River. When the effect of the designed surface runoff control measures system had been assessed for sediment transport through outlet profiles of the fourth-order catchments, the average reduction reached 43%. The total reduction in the subsurface transport of nitrogen within the fourth-order catchments was 24%. The approach and results are planned to be projected into river basin management plans for the Vltava River basin. Nevertheless, a thorough reassessment of current legislations and strategies is needed to enable the broader adoption of mitigation measures and sustainable management patterns within agricultural landscapes.
Experiencing “the Wrong Kind of Puberty”: Navigating Teenage Years with a Variation in Sex Characteristics
Authors: Joy Eileen , Lundberg Tove , Roen Katrina
Published: March 2023

There are many different variations in sex characteristics, some of which have implications for how the body goes through puberty. This paper draws from critical disability studies and childhood and youth studies to understand the teenage experiences and aspirations of young people with variations in sex characteristics, focusing particularly on navigating puberty. We undertook a reflexive thematic analysis with interview data from 12 young people in England, all assigned female at birth. Our analysis produced a central theme: aspiring to certainty through “fixing” the wrong kind of puberty. Participants experience puberty as a time where things exist on a continuum of rightness and wrongness in comparison with their peers and in relation to their specific variation. We suggest that the neoliberal aspiration to and illusion of bodily control and certainty provides the context within which the medical management of variations in sex characteristics makes sense. Going through medical intervention in relation to a variation in sex characteristics provides a very particular aspirational context for young people. The experience of puberty is intersectionally differentiated for young people with variations in sex characteristics.
New Trends and Patterns in Green Competitiveness: A Bibliometric Analysis of Evolution
Authors: Chygryn Olena , Miskiewicz Radoslaw
Published: March 2023

Global population growth, advancement of technological innovations, features of economic development, total digitization of production, and increase of consumption determine the necessity of forming companies' green competitive advantages. In order to create a terminological basis and research the main trends in the development of the concept of "green competitiveness of businesses" there was carried out a bibliometric analysis using the VOSViewer software 1.6.13 and Scopus Tools Analysis. A sample of 54,753 relevant scientific publications indexed by Scopus scientometric databases was generated for the period of 1991–2021. The results of the bibliometric analysis made it possible to determine the basic prerequisites and the main stages of forming green competitive advantages: the first is related to the traditional understanding of competitiveness, its global measurement, the development of the processes of greening economic activity; the second is related to the greening of business activities and the development of the green economy; the third is related to the analysis of competitiveness in the context of green marketing strategies; the fourth is related to shaping the concept of green competitiveness directly. The conducted research formed a theoretical basis for clarifying the content of the concept of green competitiveness as an ability of an enterprise to form and effectively use green competitive advantages, their convergent and complementary effects, which ensure the sustainable development of enterprises, the expansion of the enterprise's competitive position on the market, the increase of investment attractiveness and capitalization, and the formation of an environmental brand.
Managing the Logistic Activities of Agricultural Enterprises under Conditions of Digital Economy
Authors: Kwilinski Aleksy , Hnatyshyn Liudmyla , Prokopyshyn Oksana , Trushkina Nataliia
Published: March 2023

At the current stage of transformations, it is of urgent importance to solve the problems of logistics management in the system of agricultural enterprise management. The issues are particularly relevant under conditions of the rapid development of digital economy. Therefore, the purpose of this research is to develop further theoretical and methodological fundamentals, scientific and methodological approaches and practical recommendations to enhance the efficiency of managing the logistic activities of business entities in the agro-industrial complex allowing for the specific features of business processes digitalization. The article specifies the essence of the concept “management of the logistic activities of an agricultural enterprise” in digital economy. Problems, specific features and directions of transforming the logistics management in the agrarian sphere are identified. The work carries out a comparative analysis of the indicators reflecting trends in the global development of agriculture by applying digital instruments and technologies. The authors analyze the range of using information and communication technologies while organizing the logistic activities at Ukrainian processing enterprises. The authors reveal the key barriers hindering the digital transformation of the logistic activities of agricultural enterprises, which can be conventionally classified into 7 groups, namely institutional, market, transport, marketing, informational, organizational, financial and economic. It is confirmed that to eliminate those barriers, it is necessary to transform radically the existing system of managing the logistic activities of agricultural enterprises, which should be based on fundamentally new principles of operation under conditions of digitalization.
Principles of Nanoparticle Delivery to Solid Tumors
Authors: Chan Warren C. W.
Published: March 2023

The effective treatment of patients with cancer hinges on the delivery of therapeutics to a tumor site. Nanoparticles provide an essential transport system. We present 5 principles to consider when designing nanoparticles for cancer targeting: (a) Nanoparticles acquire biological identity in vivo, (b) organs compete for nanoparticles in circulation, (c) nanoparticles must enter solid tumors to target tumor components, (d) nanoparticles must navigate the tumor microenvironment for cellular or organelle targeting, and (e) size, shape, surface chemistry, and other physicochemical properties of nanoparticles influence their transport process to the target. This review article describes these principles and their application for engineering nanoparticle delivery systems to carry therapeutics to tumors or other disease targets.
Switchable Kirigami Structures as Window Envelopes for Energy-Efficient Buildings
Authors: Yin Hanzhi , Zhou Xishu , Zhou Zhengui , Liu Rong , Mo Xiwei , Chen Zewen , Yang Erqi , Huang Zhen , Li Hao , Wu Hao , Zhou Jun , Long Yi , Hu Bin
Published: March 2023

Efficient regulation of thermal radiation is an effective way to conserve energy consumption of buildings. Because windows are the least energy-efficient part of buildings, their thermal radiation regulation is highly demanded, especially in the changing environment, but is still a challenge. Here, by employing a kirigami structure, we design a variable-angle thermal reflector as a transparent envelope of windows for their thermal radiation modulation. The envelope can be easily switched between heating and cooling modes by loading different pre-stresses, which endow the envelope windows with the ability of temperature regulation, and the interior temperature of a building model can be reduced by ~3.3 °C under cooling mode and increased by ~3.9 °C under heating mode in the outdoor test. The improved thermal management of windows by the adaptive envelope provides an extra heating, ventilation, and air-conditioning energy savings percentage of 13% to 29% per year for buildings located in different climate zones around the world, making the kirigami envelope windows a promising way for energy-saving utilization.
Carrier Dynamics Determines the Optimization Strategies of Perovskite LEDs and PVs
Authors: Wang Saixue , Cao Yu , Peng Qiming , Huang Wei , Wang Jianpu
Published: March 2023

Metal halide perovskites have advanced greatly in both light-emitting diodes (LEDs) and photovoltaics (PVs) through delicate device engineering. The optimization strategies of perovskite LEDs and PVs have been demonstrated to be quite different. Here, we show that this dissimilarity in device fabrications can be well understood based on the analysis of carrier dynamics in LEDs and PVs.
The Association of Knowledge Management and Academic Performance in Academia
Authors: Paudel Krishna Prasad
Published: March 2023

The usage and practices of knowledge management in higher educational institutions are growing after the development of information and communication technology. Knowledge management in educational institutions has a strong link with academic activities aligned to innovative change in the research as well as teaching and learning practices. Knowledge management in academia has also a direct impact on the academic performance of faculty members where they are responsible for conducting academic activities and promoting academic discourses. In this background, this research adopts a quantitative methodology to collect data from the 445 academic staff employed at four universities in Nepal. The factor analysis was used to explore the variables and items associated with knowledge management and academic performance. This process has identified seven dimensions of knowledge management and four dimensions of academic performance. The relationship was carried out by using correlation analysis while the multiple regression analysis was used to measure the association of knowledge management and academic performance. The research shows the association between the dimensions of knowledge management and academic performance. The association and relationship of knowledge management and academic performance matter highly in academia. Furthermore, the knowledge creation process enhances the intellectual capital of every individual which has an impact on the knowledge economy of a society.
LieferradDA
Authors: Bucerius Johanna , Wolfermann Axel , Joost Jan-Marc , Schocke Oliver
Published: March 2023

Am Beispiel des Darmstädter Radlieferdienstes LieferradDA werden Herausforderungen und Lösungsansätze für nachhaltige Radlogistik beschrieben. LieferradDA startete 2020 als Reallabor zur Unterstützung des Einzelhandels (B2C) und verschob den Fokus zunehmend auf die Stadtwirtschaft (B2B). Eine Diskussion der Perspektiven verschiedener Stakeholder, der Wahrnehmung in der Öffentlichkeit und möglicher Organisationsformen zeigen Chancen und Grenzen eines Radlieferdienstes.
Akut Koroner Sendrom ile Başvuran Hastalarda Çoklu Damar Hastalığı Oranlarının Akut Koroner Sendrom Alt Tiplerine Göre Karşılaştırılması
Authors: TOSUN Veysel , FEDAİ Halil
Published: March 2023

Amaç: Akut koroner sendromlar (AKS), ST elevasyonlu miyokard enfarktüsü (STEMİ), ST elevasyonsuz miyokard enfarktüsü (NSTEMİ) ve unstabil anjina pektoris (USAP)’ ten oluşan akut damar tıkanıklıkları ile seyreden hastalık grubudur. Bu yazımızda koroner anjiyografi yapılan hastalarda AKS türleri ile çoklu damar hastalığı arasındaki ilişkiyi araştırmayı amaçladık.
Materyal ve metod: Temmuz 2019 ile Eylül 2022 tarihleri arasında AKS tanısı ile koroner anjiyografi yapılan 2048 hasta çalışmaya alındı. Hastaların epikrizlerinin yanında demografik özellikleri, lipit profili ve anjiyografi raporları incelendi. STEMİ, NSTEMİ ve USAP şeklinde 3 grup oluşturularak lipit profilleri ile darlık-tıkanıklık olan damar sayıları kaydedildi.
Bulgular: 522(%25.4) STEMİ, 1116(%54.5) NSTEMİ ve 410(%24.1) USAP çalışmaya alındı. STEMİ grubu, NSTEMİ ve USAP grubuna göre daha gençti (sırasıyla p<0.001 ve p:0.043), sigara içme oranı daha yüksekti (sırasıyla p:0.043 ve p:0.027), daha yüksek LDL-K kolesterol değerlerine sahipti (sırasıyla p:0.040 ve p<0.001). Üç ve üzeri damar hastalığı NSTEMİ ve USAP gruplarına kıyasla en yüksek STEMİ grubunda saptandı (hepsi için p<0.001). LDL-K ve HbA1c değeri ile koroner tıkanıklık-darlık olan damar sayısı arasında zayıf ama pozitif anlamlı bir ilişki mevcuttu (sırasıyla r:0.163, p<0.001; r:0.349, p<0.001); HDL-K ile de negatif bir ilişki mevcuttu (r:-0.111, p:0.001).
Sonuç: STEMİ ile gelen AKS hastalarında çoklu damar hastalığının daha fazla olduğu saptandı.
Purpose-Driven Education System Transformations: History Lessons from Korea and Japan
Authors: Crouch Luis , Spindelman Deborah
Published: March 2023

This paper is an essay in comparative educational history and its possible relevance to educational development today. It addresses the question of whether Japan and Korea’s history in using educational development to further national development can be useful as (partial) models for dealing with the educational challenges of today’s lower- and lower-middle income countries. The hypothesis of the paper is that there is much to learn from these countries, but that the lessons one could learn are not at all obvious or superficial, and are only partially about what was done (specific education policies) and are more importantly about how it was done (the high purpose and thoroughness of policy engagement). The paper first characterizes educational development, especially in terms of the intense emphasis on equality of high achievement in Korea and Japan, in quantitative terms, to demonstrate that these countries possess certain admirable characteristics. Caveats regarding learner stress and rote learning are dealt with by looking at the relevant statistics. A framework for assessing the quality of policy borrowing processes is built, based on the literature on this subject. The paper then analyzes the historical development of education as a means of resisting Western colonialist probes into Japan and Korea (end of the 19th C), but also Japan itself into Korea (first half of 20th C). How both countries borrowed from the West, but in a contested and very deep manner, and as part of a resistance to being colonized, is documented. The paper also shows that part of the healthy, contested borrowing was the involvement of teacher groups and civil society. The paper concludes by taking into consideration the fraught issue that potentiating the role of education in national development could be seen as tantamount to using education for nationalism. The paper links to the possibility that there may be a more inclusive and rights-oriented use of the concept of the nation to foster human well-being, and that education could play a role in such processes. Some practical suggestions for taking these ideas forward, or at least exploring them in more depth, are made at the very end.
Examination of proper impurity doping and annealing conditions for solution processed Ga2O3 thin films
Authors: Momota Akihiro , Shibahara Takuya , Li ChenYiZhan , Ohtani Naoki
Published: March 2023

We investigated a method to improve the resistivity of Ga2O3 thin films using a wet-process and controlling the Sn-doping conditions. Undoped and Sn-doped single layer Ga2O3 thin films were prepared by changing the solution concentration, the annealing time, the rate of temperature rise, and the speed of the sample rotation in spin coating during deposition. As a result, the films were deposited uniformly with good crystallinity and transmittance and relatively small surface roughness. To improve the resistivity by another Sn-doping method, we prepared bilayer samples consisting of undoped Ga2O3 and SnO2 layers in which Sn atoms can diffuse into the Ga2O3 layer through annealing, i.e. the drive-in diffusion method. Although the changed resistivity, X-ray electron spectroscopy (XPS) and transmission electron microscope, energy dispersion X-ray spectroscopy measurements revealed that Al diffused from the sapphire substrate, indicating a mixed β-(Ga,Al)2O3 was prepared. By changing the annealing temperature to 800 °C, Al diffusion was suppressed and pure Ga2O3 thin films were prepared. After investigating various conditions of the annealing atmosphere, we found that samples annealed in a nitrogen atmosphere for both Ga2O3 and SnO2 showed the lowest resistivity.
Exciton dynamics of a fused ring π-conjugated nonfullerene molecule based on dithienonaphthobisthiadiazole
Authors: Sato Yuki , Mikie Tsubasa , Yamada Hiroya , Osaka Itaru , Ohkita Hideo
Published: March 2023

Herein, we have studied the exciton dynamics of a novel fused ring π-conjugated molecule (YS3) in solution and film states by spectroscopic measurements. This molecule incorporates dithienonaphthobisthiadiazole as a core unit that is a two-dimensionally π-extended fused ring. As a result, we found a long exciton lifetime in YS3 films originating from reduced radiative and nonradiative transitions. This is partly because radiative deactivation is effectively suppressed because of the dipole-forbidden transition in H-aggregates and partly because rotational deactivation is effectively suppressed in the crystalline film state.
Fabrication of inverted planar perovskite solar cells using the iodine/ethanol solution method for copper iodide as a hole transport layer
Authors: Mahdy Belal , Isomura Masao , Kaneko Tetsuya
Published: March 2023

Copper iodide (CuI) is under extensive research due to its low cost, easy fabrication process, and wide bandgap. This research includes the fabrication of perovskite solar cells using the p–i–n structure (inverted structure) with a focus on the hole transport layer (HTL) layer. In this paper, we demonstrate the applicability of using CuI as a HTL in perovskite solar cells using the iodine/ethanol solution method. Using the iodine/ethanol solution for preparing the CuI, a power conversion efficiency of 0.76%, a short-circuit current density of 4.56 mA cm−2, an open-circuit voltage of 0.494 V as well as a fill factor of 0.34 were obtained. The overall performance of the solar cell still requires much improvement. We have successfully deposited the CuI using RF magnetron sputtering and the iodine/ethanol solution method and understand that the low performance of the device is mainly due to the voids and gaps present within the CuI layer.
AUSTERITY OF COVID-19 BY CHEST COMPUTERIZED TOMOGRAPHY SCORES AND INFLAMMATORY BIOMARKERS
Authors: S. Gulwe Vijaykumar , Sanjana Reddy Potu , Dasari Praphulla Indu , Koleti Kranthi , G. Maindarkar Parth
Published: March 2023

INTRODUCTION: Coronaviruses are important human and animal pathogens. At the end of 2019, a novel coronavirus
was identied as the cause of a cluster of pneumonia cases in Wuhan, a city in the Hubei Province of China. Accumulating
evidence has suggested that inammatory biomarkers and chest computerized tomography(CT) scores play a critical role in the progression of
COVID-19. CT showing ground glass opacities (GGO) and consolidations serves as an important and effective method for the diagnosis and
evaluation of severity of COVID-19. Analysis of chest computerized tomography scores wi AIM: th inammatory biomarkers in COVID-19
patients. MATERIALS & METHODS:136 laboratory conrmed cases of COVID–19 subjected to nucleic acid amplication tests such as
reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) were enrolled. They are divided into severe and non-severe groups. CT
scanner (Toshiba Aquilion Prime 160; Toshiba medical systems, Japan) was used for examining all patients. Various semi quantitative and
qualitative methods were used for biomarker assessment. RESULTS: Biomarker results mean ± SD were statistically signicant between severe
and non-severe for all biomarker parameters. CT scores and biomarkers were statistically signicant for severe group of COVID19.CONCLUSION: Elevated levels of biomarkers like D dimer, CRP, LDH, ferritin and IL-6 along with total CT severity scores are independent
risk factors for poor prognosis in patients with COVID-19, which may be a core tool for early identication of severe cases and eventually
reducing the morbidity and mortality of COVID-19
CLINICAL ASSESSMENT OF PRIMARY AND SECONDARY HYPERTENSION IN CHILDREN AND ADOLESCENTS IN TRIBAL AREA OF GUJARAT
Authors: Hathila Purva , Patel Khushbu
Published: March 2023

The aim of this study was to compare the clinical features of patients with elevated blood pressure and to detect variables
associated with the diagnosis of primary hypertension.We identified 383 (69%) hypertensive children (197)[51.5%]
with primary hypertension,and 186 [48.5%] with secondary hypertension) out of 553 children referred to our clinic with
a history of elevated blood pressure. The primary hypertension group was significantly older and had higher BMI,
positive family history of hypertension, and lower prevalence of preterm birth compared with those with secondary
hypertension. No difference was found between the two groups in terms of the frequency of target organ damage.
Multiple regression analysis showed that a family history of hypertension,obesity,age over 10 years,elevated uric acid,
and presence of higher systolic blood pressure values at admission were independent predictors of primary
hypertension;therefore,these parameters can be considered important clues for diagnosing primary hypertension
MOYAMOYA DISEASE IN A CHILD : A RARE CASE
Authors: Mamatha K. , Naveena K. , Vijai Anand Babu B.
Published: March 2023

Ÿ One of the rare causes of ischemic stroke being Moyamoya disease which is very rare in children.
Ÿ Here we report a case of 6 year old female child admitted to hospital with transient ischemic attacks and right sided
hemiparesis.
Ÿ On MR Angiography, child was diagnosed to have Moyamoya disease.This child was treated in our institute
conservatively and was referred to higher centre for specific neurosurgery
STUDY OF NEUTROPHIL TO LYMPHOCYTE RATIO AS A PROGNOSTIC MARKER IN ACUTE ST ELEVATED MYOCARDIAL INFARCTION
Authors: Choudhary Rahul , Kumar Sushil , R. Meena S.
Published: March 2023

Objectives: Previous studies have demonstrated the role of inflammation in acute STEMI. We examined cellular
inflammatory response to STEMI in the blood and its association with in-hospital mortality and/or adverse clinical
events. The neutrophil-to-lymphocyte ratio (NLR) was found to be a useful inflammatory marker for predicting adverse
outcomes. We hypothesized that an elevated neutrophil-to-lymphocyte ratio would be associated with increased
adverse outcomes in patients with acute STEMI. Material and Methods: The study consisted of 100 patients with acute
STEMI who were admitted in various wards of M.B.S. Hospital, Kota in year 2018-20, after obtaining informed consent. The
complete blood cell count (CBC) was obtained from all patients within 12-24 hours of the onset of symptoms. Total
leukocytes were counted and differential count was obtained for neutrophils, lymphocytes and neutrophil/lymphocyte
ratio (NLR) were evaluated. The patients were divided into two groups [High NLR and Low NLR] according to their
admission NLR results. Association of cellular response (NLR) with the incidence of post-MI mortality/complications was
assessed by using chi-square test with yates correction. Results showed that patients with increase Results: d NLR at
admission were having increased in hospital complication and mortality at 5 days. In-hospital mortality and post-STEMI
complication rate were 9% and 42%, respectively. Patients in high NLR group had higher rate of complications (69.4%
vs. 26.5%, p <0.001) and death (19.4% vs. 3.12%, p=0.018) in hospital than those in low NLR group. Cardiogenic shock
(36.11% vs.3.12%, p <0.001), pulmonary edema (44.44% vs. 9.37%, p<0.001), heart failure (55.55% vs. 23.43%,
p=0.003), arrhythmias (33.33% vs. 9.37%, p =0.006) occurred more in high NLR group. Risk factors were not found to
have a major impact on NLR. Differences of the risk factor data in the both groups were not statistically significant
(P > 0.05) in our study. It can be concluded that in patients with acute STEMI, NLR can be tak Conclusion: en as simple,
inexpensive, reproducible and universally available inflammatory biomarkers for determining in-hospital mortality and
complications.
A CASE REPORT : PREGNANCY IN AN UNICORNUATE UTERUS WITH NON COMMUNICATING NON CAVITATED HORN
Authors: Satish Patki Ujjwala , Patki Kulkarni Shweta , Kulkarni Shriswaroop , Satish Patki Surhud
Published: March 2023

Müllerian duct anomalies (MDA) are an uncommon but can be
a treatable form of infertility [ ]. Patients with MDA are known 1
to have higher incidences of infertility, repeated first
trimester spontaneous abortions, fetal intra-uterine growth
retardation, fetal malposition, pre-term labour and retained
placenta [
A STUDY OF DECREASING RETINAL THICKNESS WITH AGE USING OPTICAL COHERENCE TOMOGRAPHY
Authors: Shankar Naina , V Sujatha , Kumar Srivastava Vijay , BA Pallavi , A Amudha
Published: March 2023

Aim/purpose: To study and correlate the change in retinal thickness with age and to establish a clinical importance
between the two factors. A number of 50 healthy subjects between the ages of 18-65 years on outpatie Methods: nt basis
were taken and evaluated. Pupils of the subjects were dilated with tropicamide 0.8% and OCT Optic Disc scan was
performed on each eye using the Cirrus HD OCT 500. The total retinal thickness and retinal nerve fiber layer (RFNL)
thickness were noted. Out of the 50 subjects, 48% of them were female and 52% of them male. The mean RESULTS:
retinal thickness was 234.78 μm ± 16.07 with a coefficient of variation of 6.8%. The mean RFNL was 84.6 μm ± 20.67 with a
coefficient of variation of 24.4%. Linear regression plots are done using x variable as age and y variable as RFNL/Total
retinal thickness and using the formula Y = mx + b, it is plotted against a graph for each of the two variables. Unpaired t
test used, t = 13.8599. The value P<0.001 and was considered statistically significant. According to CONCLUSION: this
study, retinal thickness significantly decreases with age. Hence, it is important to perform OCT as a screening process in
older individuals to rule out diabetic changes, macular edema, to detect thinning of the retina in myopics as a risk factor
for RD and to rule out other pathologies.
ASSESSMENT OF PHYTOCHEMICALS IN MORINGA OLEIFERA LAM. LEAVES: AN INDIAN MIRACULOUS TREE
Authors: Sutradhar Shubham , Md Ashif Ikbal Abu
Published: March 2023

Background and Aim: Moringa oleifera (Moringaceae) has been used as a traditional herbal medicine in many tropical
and subtropical nations for ages. Having phenolic, alkaloid, and flavonoid compounds as major constituents, the leaf
extract has been reported to exhibit antioxidant activity both in-vitro and in-vivo. To acquire the maximum yield of these
compounds, which consequently influence the antioxidant activity, 6 different extraction solvents were used in this
research project using the maceration method. Petroleum ether, ethyl acetate, chloroform, ethanol, Methodology:
methanol, and water were used to extract fresh and dried leaves of M. oleifera. 3 consecutive macerations were used for
each of the solvent extracts and the percentage yield of each extract was calculated. Finally, the total phenolic content
(TPC), total alkaloid content (TAC) and total flavonoid content (TFC) of all the samples were determined. Conclusion:
Through this research work and all the Practically observed data, it can be concluded that methanol is the perfect solvent
to extract the optimum amount of phytochemicals which showed maximum amount of yield percentage, TPC and TFC.
Although there was a point to be noted that for TAC, the chloroform extract showed the maximum amount of content,
which is 5.37mg/g approximately. With the help of this study, one can now easily select the choice of solvent for specific
phytochemical extraction for the separation of active constituents.
ECG CHANGES IN ALUMINIUM PHOSPHIDE POISONING
Authors: Kumar Biloni Shailendra , Kumar Nehr Nikhil , Singh Chara Karan , Gupta Deepak
Published: March 2023

Background: Aluminium phosphide is a solid fumigant pesticide.Aluminium phosphide (AlP) is a common suicidal
poison with a high mortality rate due to its cardiovascular impact and lack of antidote. The clinical spectrum of
poisoning varies depending upon the dosage and duration of consumption.The main effect of the poison is due to the
release of phosphine which inhibits cytochrome oxidase and thereby hampers cellular oxygen utilization.Death is due
to its direct toxic effect over the heart leading to peripheral circulatory failure.The aim of the study was to describe the
electrocardiographic changes in Aluminium phosphide poisoning. Methods: 36 patients,who were admitted in MICU,
following consumption of aluminium phosphide tablets were included in the study. Patients clinical evaluation was
done.ECG of the patients was done to study the cardiac abnormalities. Results: Out of 36 cases,ECG was normal in 16
cases and abnormal in 20 cases. Atrial fibrillation was most common finding-6 patients (30%), supraventricular
tachycardia-2 (10%),ventricular tachycardia-2 (10%),ST-T changes-6 { ST elevation-4 (20%) and ST depression-2 (10%)
},bundle branch block-1 (5%),prolonged QTc-3 (15%).Conclusions: ECG was done bedside, it is a cost effective tool
and should be done in all cases.Whenever it is available, it must be done in cases of aluminium phosphide poisoning.
Thus, proper clinical work out along with relevant investigations and management as per standard protocol may save
many more live
MR FEATURES OF SPINDLE CELL LIPOMA IN THE ANTERIOR ABDOMINAL WALL
Authors: Sethumadhavan Sreenath , Benjamin Geena
Published: March 2023

Lipoma, made of mature fat cells, represent the commonest
benign mesenchymal neoplasm of the body. Lipoma accounts
for almost 50% of all soft-tissue tumors. However, they are not
commonly seen in the anterior abdominal wall. A rare variant
of lipoma composed of fat and non-adipose tissue is spindle
cell lipoma, which is commonly located in the subcutaneous
tissue of posterior aspect of neck, back and shoulder
Impact of Hyperviscosity of Blood on Elevation of Blood Pressure among the Adulthood at Baghdad City
Authors: Hattab Waffa Abed Ali
Published: March 2023

Objective of The study: The study aims to assess the of blood pressure in hypervelocity patients, and find out the relationship between of blood pressure and secondary polycythemia
Methodology: descriptive design study was starting in 1st of July 2014 to the 1st of September 2014. The study conducted on 54 persons who attended to blood bank to blood donation. The instruments were composed of four parts. The first part was concerned with the socio-demographic characteristics, second part deals the past and present medical history, third part was a personal behavior, and fourth part consist of the measuring hemoglobin level , and Blood Pressure before and after blood donation, the data was collected by using personal interview by responders to fill the personal socio-demographic characteristics, and medical problems, and the researchers measure the hemoglobin level for the persons before blood donation, and measure the blood pressure before and after donation and the data was analyzed by the application of descriptive and inferential statistical methods.
Results: The results revealed that the demographic characteristics of the study sample was 96.3% were males,22.2% of them at age 23-27 years old, 68.5% were married, 35.2% graduated of secondary school, 37% ofthem was employment, and 44.4% of them sufficient income, smoking history for the study sample was revealedthat 100% of them was smoker, 64.8% of them continues of smoking, 94.3% was intermittent to smoking, 87%of them was used the water pipe, 18.5% of them continuous to used and 90.8% was intermittent for water pipeused.
Conclusion: the study concluded that the range of blood pressure reading for the study sample was changesof before to after blood draw and it is reduced the percent of high blood pressure after blood draw, that therewere significant relationship between high level of hemoglobin and elevation of blood pressure at P≥0.05 value.
Recommendation: Based on the findings of present study the researcher recommended to implementingeffective strategies to control tobacco exposure, measurement of carboxyhemoglobin should be a routine part ofthe evaluation of all hypervelocity patients, and labor sticking to increase recreation centers and arenas dedicatedto sport.
Due Process of Law: Pre-trial and Preliminary Examination Judge on Indonesian Criminal Procedure Law
Authors: Faisal Fitriah
Published: March 2023

The purpose of this research is to find out whether the pretrial institution has realized the due process of law as aspired by the criminal procedural law and what about the pretrial reform institution in the RKUHAP, namely the Preliminary Examination Judge, whether it has been able to reflect the due process of law. The type of research in this study is normative. The data source used is secondary data which contains primary, secondary and tertiary legal materials. The data was collected by using library techniques and analyzed by qualitative methods and will be described systematically or prescriptively. From the Research It was found that the current pretrial does not reflect the due process of law, so it is necessary to immediately approve the reform of the pre-trial institution. Then the pretrial substitute institution, namely the Preliminary Examination Judge has greater authority than pretrial regarding the rights of the suspect, so that the establishment of this pretrial substitute institution is expected to have the purpose of criminal procedural law: due process of law or behoorlijk procesrecht in order to seek material truth or objective truth and the purpose to protecting the human rights of suspects and defendants can be achieved.
Online + International: Utilizing Theory to Maximize Intercultural Learning in Virtual Exchange Courses
Authors: Nyunt Gudrun , Niehaus Elizabeth , Light Ashley , Boryca Alex , Bryan Angela
Published: March 2023

Virtual exchanges (VEs) are course-based experiences designed to promote global learning, often by integrating cross-cultural interactions and collaborations with people from other areas of the world into coursework in a virtual format. Due to the widespread disruption of the COVID-19 pandemic, VEs have seen an increase in popularity. However, research findings on the effectiveness of VEs are mixed, and limited guidance is available to VE instructors on how to structure and facilitate these programs. The purpose of this paper is to highlight how theories and literature in two distinct areas of scholarship, Intergroup Contact theory and the Community of Inquiry model in online learning, could be applied to VEs to maximize student learning. We discuss each of these theories first and then highlight how they could be applied to VEs using illustrative examples from a pilot study of five VE courses offered at one institution during the summer of 2021.
Evaluation of Acute Drug Intoxications and Drug Use in the Intensive Care Unit: A Retrospective, Single-Center Analysis
Authors: ARSLAN Kadir , ŞAHİN Ayça Sultan
Published: March 2023

Aim: Drug intoxications and drug uses are public health problems and an important reason for patient admission to emergency departments and intensive care units (ICU).This study aims to evaluate the demographic and clinical data of acute drug intoxications and drug use.

Methods: Patients followed up in the ICU for acute drug intoxications and drug use between January 2014 and January 2020 were evaluated retrospectively.

Results: A total of 194 patients were included in the study, including 168 drug intoxication and 26 drug use. While 59.5% of drug intoxications were female, the mean age was 27.8±8.3 years, 92.3% of drug use was male, and the mean age was 26.5±3.8 years. While the mean duration of stay in the ICU was 2.3±1.2 days for drug intoxications, it was 2.8±1.9 days for drug use. The highest rate of drug intoxication was between the ages of 17-30, and 98.8% of them were suicidal. Most of the intoxications (61.9%) occurred with multiple drugs, most commonly with analgesics (40.4%) and antidepressants (34.5%). The mortality rate of drug intoxication was 0.6%, and the mortality rate of drug users was 11.5%. While male gender and mechanical ventilation (Mv) requirement were significantly higher in drug use, Glasgow coma scale (GCS) scores at discharge and hospitalization were significantly lower (p
Training and Mentoring on the Use of Information and Communication Technology (ICT) in Supporting the Implementation of Learning at UPT SD Negeri 342 Gresik
Authors: Pance Mariati  , Afib Rulyansah  , Sri Hartatik  , Nafiah  , Sunanto
Published: March 2023

Abstract: UPT SD Negeri 342 is one of the schools in Sangkapura Bawean District, which is located in the mountains. This school has very minimal facilities compared to other schools in the area. The implementation of online learning, administration and the use of technology-based learning media are not maximally implemented in these schools. Therefore, training and assistance in the use of information and communication technology is carried out. Participants consisted of 8 teachers and 36 students. The training is carried out face-to-face, followed by online and offline mentoring. The training materials presented were Augmented Reality (AR) in the Arloopa application, the use of The Physics Education Technology (PhET) for virtual student practicums, mentimeters, and zoom meetings. After the work program is implemented, an evaluation will be held to identify capacity building and its strengths and weaknesses as material for improvement in the next implementation. The results of the training showed that the ICT skills of teachers and students increased from previously unable to become able. All the teachers attended the training and participated enthusiastically. The material presented can be understood clearly and participants can apply it independently. They just need habituation to better master the material that has been given. This training activity had a good impact on improving the ICT skills of teachers and students at UPT SD Negeri 342 Gresik.
APPLICATION OF THE ENERGY METHOD FOR STRENGTH EVALUATION OF PIPELINE LIFE IN THE PRESENCE OF A MACRODEFECT
Authors: Малинин В.Г. , Савич В.Л. , Отев К.С.
Published: March 2023

Исследуется осевое растяжение плоских стальных образцов с искусственными дефектами продольной и поперечной ориентации относительно центральной оси растяжения. Выполняется анализ теоретико-экспериментальных исследований энергетическим методом обработки диаграмм испытаний на растяжение изделий. Дается обоснование выбора коэффициентов для диагностики изделия и определения его слабых мест при анализе напряжённо-деформированного состояния.

Axial tension of flat steel specimens with artificial defects of longitudinal and transverse orientation relative to the central axis of tension is investigated. The analysis of theoretical and experimental studies by the energy method of processing diagrams of tensile tests of products is carried out. The substantiation of the choice of coefficients for the diagnostics of the product and the determination of its weak points in the analysis of the stress-strain state is given.