bluuebunny/crossref_metadata_2025 huggingface dataset:
Propuesta de un modelo de gestión por procesos según BPM e ITIL V4 para la gestión de incidencias referidas a la administración de servicios tecnológicos prestados por IBM del Perú S.A.C. a su cliente Casa de apuestas deportivas S.A.
Authors:   , Adrianzen Espinoza Gino Yampiere
Published: November 2022

El análisis de esta investigación está enfocado en la gestión de incidencias y el proceso establecido para ellas, actualmente existen más de 25,000 ticket de incidencias, esta problemática se puede evidenciar haciendo una comparación entre el primer trimestre del año 2019, 2020 respecto al año 2021, haciendo un análisis y tomando el control de los inventarios, sensibilización de la cuentas, trasferencia de conocimientos, documentación, conocimientos contractuales y mejoras, en su totalidad, se puede demostrar cómo se mejorar la gestión de incidencias de una manera más eficiente a lo largo del desarrollo de esta tesis, donde se podrá medir de manera independiente los siguientes parámetros como son; cantidad de incidencias reportadas detalladas de acuerdo a los niveles de prioridad 1, 2, 3 y 4, cantidad y porcentaje de incidencias que generan problemas, cantidad de incidencias que fueron escalados, y así ,mismo los tiempos promedios de atención para dichas incidencias basado en los SLA respecto al servicio contratados del cliente CASA DE APUESTAS DEPORTIVAS S.A. El objetivo principal de esta investigación es demostrar cómo se puede mejorar el proceso actual para la gestión de incidencia en la empresa IBM del Perú S.A.C. para ello se utilizará la buenas prácticas de ITIL V4 y además se aplica el marco teórico del BPM, de esta manera se podrá demostrar como estos dos marcos teórico pueden interactuar de manera holística permitiendo conversar entre sí para poder cumplir con el objetivo principal, este demostrará cómo es posible reducir la volumetría de incidencias, y así mismo mejorar los tiempos de atención y resolución.
Relación entre la impactación de terceras molares inferiores y la posición antero posterior de la mandíbula
Authors:   , Julca Puente Jesus Alberto
Published: November 2022

Objetivo: La relación entre la posición de terceros molares inferiores impactados según la clasificación de Pell & Gregory es de gran importancia para el clínico para saber el abordaje de tratamientos. Por otro lado, el ángulo SNB ayuda a determinar el crecimiento y posición antero posterior de la mandíbula. A lo largo de los años, se ha desarrollado investigaciones relacionando estos dos tópicos. El objetivo del estudio fue determinar la relación entre la posición de los terceros molares inferiores impactados y la posición antero posterior de la mandíbula, este trabajo de investigación se hizo exclusivamente en una población peruana y servirá como ayuda diagnóstica en diversas especialidades de la profesión. Método: Se evaluaron 224 terceras molares de 112 radiografías panorámicas y cefalométricas de la base de datos del Centro Radiológico DentoImagen de pacientes entre 18 a 25 años de edad. Hubo varios criterios de inclusión como radiografías estrictamente nítidas, las radiografías cefalométricas estrictas con el plano de Frankfurt paralelo al borde inferior de la placa con una aproximación de 1mm y/o 1 grado. Resultados: Se mostró que gran parte de las mediciones realizadas en las radiografías cefalométricas se encuentran en una posición antero posterior ideal de la mandíbula de acuerdo con el SNB. Además, que la ubicación de la tercera molar se encuentra en relación II de Pell y Gregory. Por último, el sexo femenino tiende a desarrollar una mandíbula más corta a diferencia del sexo masculino donde hay mayor tendencia a desarrollar una mandíbula prominente. Conclusiones: Hubo mayor número de radiografías con valores normales del ángulo SNB y clase II de Pell y Gregory. Se encontró relación entre la posición antero posterior de la mandíbula y el sexo. Sin embargo, no hubo relación entre la impactación de terceras molares inferiores y la posición antero posterior de la mandíbula.
Riesgo de depresión y aislamiento social en el adulto mayor del Centro de Salud "Trébol Azul"-San Juan de Miraflores. Lima-Perú, 2020
Authors:   , Trebejo Chumbile Isabella Sandy , Paucar Rojas Alondra
Published: November 2022

Objetivo: Determinar la relación entre el riesgo de depresión y el aislamiento social en el adulto mayor del C.S. “Trébol azul” de S.J.M. Lima - Perú. Métodos: Investigación aplicada de nivel correlacional, el diseño es no experimental de corte transversal, según la DIRIS Lima Sur la población de adultos mayores que asisten al C.S. Trébol Azul es de 3057; el muestreo utilizado fue el no probabilístico por conveniencia de las investigadoras con una muestra de 341 adultos mayores; la técnica de recolección de datos utilizados fueron la encuesta y el instrumento fue el cuestionario. Resultados: El P valor es 0,000 cómo es < a 0,05; es estadísticamente significativo lo que muestra que existe una asociación entre riesgo de depresión y aislamiento social. El 58% de adultos mayores presentan riesgo de depresión moderado seguido del 26% que presentan riesgo de depresión severa y el 16% no evidencia riesgo de depresión, asimismo, el 77% de adultos mayores presentan alto riesgo de aislamiento social, seguido del 23% que presentan bajo riesgo de aislamiento social y 0% ausencia de aislamiento social. En la hipótesis se afirmó que existe relación representativa entre las dos variables estudiadas riesgo de depresión y aislamiento social en los adultos mayores del C.S. Trébol Azul. Conclusiones: La depresión en los adultos mayores está relacionada con el aislamiento social. Son problemas de salud pública comprometiendo el bienestar emocional y psicológico.
Percepción del uso de la telepsicología y satisfacción laboral en profesionales psicólogos de Lima Metropolitana en tiempos del COVID-19
Authors:   , Barreto Antonio Marita Milagros
Published: November 2022

La finalidad del presente estudio fue analizar la relación entre la percepción del uso de la telepsicología y la satisfacción laboral en psicólogos profesionales de Lima Metropolitana en tiempos del COVID 19. La muestra fue por conveniencia conformado por 123 profesionales de Psicología que residen en Lima Metropolitana, siendo del género femenino el 60,2% (N=74) y masculino 39,8%. (N=49). El enfoque del estudio es cuantitativo de tipo básico, descriptivo, exploratorio, con un diseño no experimental, correlacional y transversal. Los instrumentos utilizados fueron la encuesta Ad Hoc, el Cuestionario de percepción de la Telepsicología y el Cuestionario de “Satisfacción Laboral”. Estos resultados muestran que no existe una relación entre la percepción del uso de la Telepsicología y satisfacción laboral a nivel general (Rho=0.144; p=0.111), en cuanto a las dimensiones condiciones físicas/o materiales (Rho=0.210; p=0,020) y políticas administrativas (Rho=-0.182; p=0.044) presentan una correlación significativa con la percepción del uso de la telepsicología. asimismo, se evidenció que existen preocupaciones como la falta de conocimientos técnicos propios (22%), acceso limitado a la conexión o cortes en la comunicación (20,3%), percepción de ausencia o escasa evidencia científica de la efectividad de la telepsicología dentro del país (5,7%). Estos hallazgos plantean la acción inmediata para proponer estrategias que ayuden a obtener mejoras para la prestación de servicios en tiempo de crisis en el Perú.
Conocimiento sobre salud bucal de los padres y su relación con los hábitos de higiene bucal de estudiantes con discapacidad: revisión sistemática
Authors:   , Hinostroza Acevedo Stephanie
Published: November 2022

La salud bucal en los niños con discapacidad siempre se ve afectada, siendo esta causada por una deficiente motricidad manual y la falta de cuidado de sus padres. El objetivo de este trabajo fue determinar la relación entre el conocimiento sobre salud bucal de los padres y los hábitos de higiene bucal de sus hijos con discapacidad, a través de una revisión sistemática de la literatura. En la búsqueda de los artículos se realizó pasando por diferentes filtros donde primero, se revisaron en 7 bases de datos (Scopus, Medline vía Pubmed, Ebsco, Science Direct, Scielo, Google Scholar (Literatura Gris), Lilacs) y 5 revistas de mayor impacto en Odontopediatría en una búsqueda primaria. Luego se hizo una eliminación por duplicados, título, abstract y por lectura completa; todos basándose por los criterios de elegibilidad y la estrategia PICOS, donde solo se llegó a encontrar 7 artículos que cumplían todos los criterios de inclusión. Se concluye que según la literatura el nivel de conocimiento de los padres sobre salud bucal es regular y se encuentra relacionado con los hábitos de higiene bucal que presentan sus hijos con discapacidad. Existe una relación que a mayor grado de estudios que presenten los padres, su nivel de conocimiento sobre salud bucal y los hábitos de higiene bucal de sus hijos con discapacidad será más alto.
Análisis tridimensional de la distribución de estrés de carillas oclusales de disilicato de litio y resina compuesta con diferentes terminaciones marginales
Authors:   , Aliaga Fernandez Jimmy
Published: November 2022

Objetivo: Evaluar la distribución de estrés al aplicar fuerzas verticales y tangenciales en carillas oclusales de 1 mm de espesor con diferentes líneas de terminación marginal por el método de elementos finitos. Materiales y métodos: Se preparó un tercer molar extraído para carilla oclusal, primero sin bisel. Se escaneó para diseñar dos grupos de carillas oclusales de disilicato de litio (G1A, G2A) y resina compuesta (G1B, G2B). Después, esta preparación molar fue modificada, biselando la línea de terminación y escaneándola nuevamente para diseñar los grupos de carillas oclusales con bisel (DL: G3A, G4A and RC: G3B, G4B). Los 4 grupos fueron sometidos a fuerzas diferentes (400 N vertical y 900 N tangencial). Resultados: Con 400 N, las carillas sin bisel presentaron ligera mayor tensión de Von Mises (G1A: 783 MPa y G1B 736.5 MPa) que las carillas con bisel (G3A: 685.7 MPa y G3B: 675.8 MPa). De distinta forma, al aplicar fuerzas tangenciales de 900 N, las carillas oclusales con bisel presentaron mayor tensión de Von Mises (G4A: 4297 MPa y G4B: 4133 MPa) que las carillas oclusales sin bisel (G2A: 2581.1 MPa y G2B: 3519.1 MPa). Además, se observó que los tejidos subyacentes a las carillas oclusales con bisel, presentaron mayor tensión de Von Mises, frente a los modelos sin bisel. Conclusión: Las carillas oclusales con y sin bisel de disilicato de litio y resina compuesta presentaron una distribución de estrés similar con fuerzas verticales de 400 N, por otro lado, con fuerzas tangenciales de 900 N, los grupos con bisel presentaron notablemente mayor tensión que los grupos sin bisel. Sin embargo, ambos diseños de terminación marginal presentaron valores adecuados para un posible desempeño clínico.
Research on the Effects of Welding Defects on the Strength Performance of Expandable Profile Liners and Approaches to Improve Welding Reliability
Authors: Zhao Le , Tu Yulin , Gao Mingzhong
Published: November 2022

Expandable profile liner (EPL) technology (EPLT) provides an effective solution for lost circulation trouble control without wellbore diameter loss or sacrificing completion and production performance. However, the reliability and stability of the welding seams determine the overall bearing capacity of the EPL string. The application of EPLT in more complicated conditions requires increasing the overall performance of the EPL string welding seams. In this study, we considered four types of artificial welding defects, including cracks, pores, slag inclusions, and incomplete penetration in EPL string samples, and performed internal pressure limit tests to obtain the ultimate failure strength of EPL strings with different welding defects. Abaqus was used to quantitatively assess the influence of welding defects on the strength performance of the EPL string. The critical dimensions and safety evaluation curves of various defects, under a working pressure of 30 MPa (safety factor 1.5), were obtained using a combination of numerical simulations and experiments. Using the latest welding defect identification and detection methods and relevant evaluation procedures, the type, size, and position of welding defects in EPL string can be identified quickly. The new welding process and integrated automatic welding equipment improved the welding quality and reliability of the EPL string. The new research on EPL welding seam defects and recent advancements in EPLT can bring significant economic benefits, thus promoting the application of EPLT to meet future application challenges. The technical innovations presented in this study provide an effective solution for drilling engineering staff to solve the drilling troubles associated with lost circulation and borehole instabilities and are also conducive for oil companies to address the future challenges of exploitation and development of unconventional oil and gas resources.
Synaptotagmin-like protein 1 is a potential diagnostic and prognostic biomarker in endometrial cancer based on bioinformatics and experiments
Authors: Meijuan Cai , Meng Xu , Fang Liu , Qian Wang
Published: November 2022

Backgroud: Endometrial cancer (EC) is one of the most common gynecologic malignancies. Identification of potential EC biomarkers is essential to improve the prognosis and development of therapies against EC. Synaptotagmin-like protein 1 (SYTL1), as a small GTPase Rab27 effector, mainly plays a role in vesicle trafficking and cytotoxic granule exocytosis in lymphocytes. However the role of SYTL1 in EC remains uncertain. We performed a comprehensive assessment of the relationship between SYTL1 and patient diagnosis and prognosis by analysis of EC patients data from TCGA. We employed the LinkedOmics and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database to analyze the biological function of SYTL1 in EC. In addition, the correlation between SYTL1 expression and its DNA methylation was performed by using cBioportal, UALCAN, TCGA Wanderer and MethSurv databases. We further assessed the link between SYTL1 and tumor-infiltrating immune cells by using gene set variation analysis (GSVA).
Results: We found that SYTL1 was highly expressed in EC patients and cell lines. And increased expression of SYTL1 was associated with age, clinical stage, histological type, histological grade and good overall survival (OS). SYTL1 DNA methylation is negatively associated with SYTL1 expression and UCEC patients’ OS. SYTL1 expression is closely correlated with immune infiltration. Furthermore, we carried out in vitro experiments to verify the results of bioinformatic analyisis. Conclusions: Our results demonstrated that the elevation of SYTL1 expression is associated with good OS and SYTL1 might be a potential diagnostic and prognostic marker in EC.
Ring Repeating Unit: A Deterministic Structure Representation of Polymers for Property Predictions
Authors: Yu Mengxian , Shi Yajuan , Jia Qingzhu , Wang Qiang , Luo Zheng-Hong , Yan Fangyou , Zhou Yin-Ning
Published: November 2022

Deterministic structure representation of polymers plays a crucial role in developing models for polymer property prediction and polymer design by data-centric approaches. Currently, unique structure representations of polymers, especially the polymers with heteroatomic backbones, are unavailable. In this contribution, we propose a so-called ring repeating unit (RRU) method that can uniquely represent polymers with a broad range of structure diversity. To prove the rationality of RRU-based structure representation for generating feature descriptors, a quantitative structure property relationship (QSPR) model for glass transition temperature (Tg) was established for 1321 polyimides with good accuracy (R2 = 0.8793). Comprehensive model validations including external, internal, and Y-random validations were performed, providing Tg prediction result with an average absolute error (AAE) of 19.38 ℃. It is believed that the as-developed RRU method allows for dealing with any macromolecular structure and targeted property, enabling for reliable polymer property prediction and high-performance polymer design by data-driven approaches.
Superior biological traits of invaded (Caribbean) versus native (Red Sea) populations of the seagrass Halophila stipulacea
Authors: Winters Gidon , Conte Chiara , Beca-Carretero Pedro , Nguyen Hung Manh , Migliore Luciana , Mulas Martina , Rilov Gil , Guy-Haim Tamar , González María J. , Medina Isabel , Golomb Dar , Kitson-Walters Kimani
Published: November 2022

The seagrass Halophila stipulacea is native to the Red Sea. It invaded the Mediterranean over the past century and most of the Caribbean over the last two decades. Understanding the main drivers behind the successful invasiveness of H. stipulacea has become crucial. We performed a comprehensive study including field measurements, a mesocosm experiment, and a literature review to identify ‘superior traits’ that can potentially explain the success story of H. stipulacea. We assessed meadow characteristics and plant traits of three invasive H. stipulacea populations growing off the Island of Sint Eustatius (eastern Caribbean). We compared similar parameters between native (Eilat, Red Sea) and invasive H. stipulacea plants in a common-garden mesocosm. Lastly, we also compared our field measurements with published data. The newly arrived H. stipulacea plants from St. Eustatius were characterized by higher percent cover, higher below- and above-ground biomasses, more apical shoots, and faster leaf turnover rates than those measured in both native and older invaded habitats. These results were further confirmed by mesocosm experiments where the invasive H. stipulacea plants grew faster and developed more apical shoots than the native plants. Results suggest that increased growth vigour is one of the main invasive traits that characterize successful invasive H. stipulacea populations in the Caribbean and potentially in other invaded areas. We encourage long-term monitoring of H. stipulacea in both native and invaded habitats to better understand the future spread of this species and its impacts on communities and their ecosystem functions and services.
Valve Block Flow Channel Planning Based On Additive Manufacturing And Ant Colony Algorithm
Authors: Li Ying , Li Ziyang , Zhang Yuying , Liu Yandong , Zhang Jin , Kong Xiangdong
Published: November 2022

Hydraulic valve block is an important part of aviation Electro-Hydrostatic Actuator (EHA). With the development of EHA in the direction of light weight and integration, the internal flow channel of the hydraulic valve block is required to be more compact. Based on the technical means provided by additive manufacturing technology, this paper adopts the Ant Colony Algorithm + B-spline curve to design the internal flow channel of the aviation EHA valve block, and realizes the automatic arrangement of the flow channel by computer. The flow characteristics of the flow channel before and after optimization are analyzed. The volume of the flow channel after optimization is reduced by , besides the pressure loss measured by the test is reduced by to . The feasibility of optimizing the design of flow channel by Ant Colony Algorithm and B-spline curve is verified, which provides a solution for flow channel design method based on additive manufacturing.
Spatio-temporal variation of in-cabin PM 2.5 levels in Metro Rolling Stock Saloons, Kochi Metro, South India
Authors: Akhilesh K. B. , Akhila T. , Madhuraj P. K. , Anjali T. B. , Anand M.
Published: November 2022

Increasing particulate matter (PM) especially PM2.5 (particles less than 2.5µm in aerodynamic diameter), pollution in the air-conditioned indoor microenvironment can spread infectious diseases such as Covid-19 on occupants in addition to respiratory and cardiovascular diseases. Given the importance of this subject in the contemporary social context, this study seeks to assess the spatiotemporal variation of PM2.5 concentration in Metro Rolling Stock (MRS) saloons of Kochi Metro Rail Limited (KMRL), Kerala, India. During the in-transit survey data was collected according to the four different plans depending on the time and direction of the metro service using a real-time Indoor Air Quality (IAQ) monitor. The spatial variation in PM2.5 content en-route 22 stations (Aluva to Petta) shows, Kalamassery Town station recorded the maximum value of 40.33µg/m3 and station Maharajas Ground recorded the lowest value of 23.95µg/m3 respectively. Comparing the median concentration of PM2.5 of the four plans implied that plan-1 (Aluva-Petta during morning peak hours) record the highest concentration than other plans (p-value < 0.05). Principal Component Analysis biplots, did not display strong positive associations among PM2.5 and the other in-transit variables such as temperature, relative humidity, carbon dioxide concentration, and the number of occupants. Therefore, the study infers that the infiltration of outdoor air when the doors are opened at each station could be the influencing factor of PM2.5 level in MRS saloons of KMRL. Moreover, the proximity to traffic signals, industrial establishments, and muncipal waste dumping sites increase the probability of PM2.5 level which was evident at Kalamassery Town station.
An all-37°C thawing method improves the clinical outcomes of vitrified frozen-thawed embryo transfer: a retrospective study using a case-control matching analysis
Authors: Yan Gaofeng , Yao Youlin , Yang Wenjuan , Lu Ling , Wang Longda , Zhao Di , Zhao Shuhua
Published: November 2022

Purpose
The purpose of this study is to assess the impact of different temperatures and equilibrium times on the clinical outcomes of FET cycles during the thawing procedure and to select a better thawing method to improve clinical outcomes.
Methods
This retrospective study included 1,734 FET cycles from January 1, 2020, to January 30, 2022. Embryos vitrified using a Kitazato Vitrification Kit were thawed at 37°C in all steps (the case group, denoted the “all-37°C” group) or at 37°C and then at room temperature (RT; the control group, denoted the “37℃-RT” group), according to the kit instructions. The groups were matched 1:1 to avoid confounding.
Results
After case-control matching, 366 all-37°C cycles and 366 37℃-RT cycles were included. The baseline characteristics were similar (all P > 0.05) between the two groups after matching. FET of the all-37°C group yielded a higher clinical pregnancy rate (CPR; P = 0.009) and implantation rate (IR; P = 0.019) than FET of the 37℃-RT group. For blastocyst transfers, the CPR (P = 0.019) and IR (P = 0.025) were significantly higher in the all-37°C group than in the 37℃-RT group. For cleavage embryo transfers, the CPR and IR were non-significantly higher in the all-37°C group than in the 37℃-RT group (P > 0.05).
Conclusions
Thawing vitrified embryos at 37°C in all steps during FET cycles can enhance CPR and IR. Well-designed prospective studies are warranted to further evaluate the efficacy and safety of the all-37°C thawing method.
The OptimaMed intervention to reduce medication burden in nursing home residents with severe dementia: Results from a pragmatic, controlled study
Authors: Kröger Edeltraut , Wilchesky Machelle , Morin Michèle , Carmichael Pierre-Hugues , Marcotte Martine , Misson Lucie , Plante Jonathan , Voyer Philippe , Durand Pierre
Published: November 2022

Background: Nursing home (NH) residents with severe dementia use many medications, sometimes inappropriately within a comfort care approach. Medications should be regularly reviewed and eventually deprescribed. This pragmatic, controlled trial assessed the effect of an interprofessional knowledge exchange (KE) intervention to decrease medication load and the use of medications of questionable benefit among these residents.
Methods: A 6-month intervention was performed in 4 NHs in the Quebec City area, while 3 NHs, with comparable admissions criteria, served as controls. Published lists of “mostly”, “sometimes” or “exceptionally” appropriate medications, tailored for NH residents with severe dementia, were used. The intervention included 1) information for participants’ families about medication use in severe dementia; 2) a 90-minute KE session for NH nurses, pharmacists, and physicians; 3) medication reviews by NH pharmacists using the lists; 4) discussions on recommended changes with nurses and physicians. Participants’ levels of agitation and pain were evaluated using validated scales at baseline and follow-up.
Results: Seven (7) NHs and 123 participants were included for study. The mean number of regular medications per participant decreased from 7.1 to 6.6 in the intervention, and from 7.7 to 5.9 in the control NHs (p-value for the difference in differences test: < 0.05). Levels of agitation decreased by 8.3% in the intervention, and by 1.4% in the control NHs (p=0.026); pain levels decreased by 12.6% in the intervention and increased by 7% in the control NHs (p=0.049). Proportions of participants receiving regular medications deemed only exceptionally appropriate decreased from 19% to 17% (p=0.43) in the intervention and from 28% to 21% (p=0.007) in the control NHs (p=0.22). The mean numbers of regular daily antipsychotics per participant fell from 0.64 to 0.58 in the intervention and from 0.39 to 0.30 in the control NHs (p=0.27).
Conclusions: This interprofessional intervention to reduce inappropriate medication use in NH residents with severe dementia decreased medication load in both intervention and control NHs, without important concomitant increase in agitation, but mixed effects on pain levels. Practice changes and heterogeneity within these 7 NHs, and a ceiling effect in medication optimization likely interfered with the intervention.
The study is registered at ClinicalTrials.gov : # NCT05155748 (first registration 14-12-2021)
Effect of ambient factors over spinel CuMn2O4 for toluene catalytic ozonation: Enhancement of the synergy and the generation of ROS
Authors: Wang Guanjie , Zhao Bo , Ye Zhiping , Zhao Liang , Zhang Xiuwen , Wang Jiade
Published: November 2022

Herein, the effect of ambient factors (O3 concentration, temperature, and humidity) was explored in catalytic ozonation of toluene by using CuMn2O4, which possessed a great steady-state activity (~ 73%) at the optimal conditions (2100 ppm O3, 100℃, and dry air). Under various conditions, a strong correlation was observed between O3 consumption, toluene oxidation, and COx formation. The technology of DRIFTS and GC-MS were used to study the effects of influencing factors on the toluene degradation process. Cu+ plays an important role in the adsorption of toluene and the oxidation of toluene to benzoic acid. The ·OH and temperature suppressed the deposition of carbonaceous by-products. On the other hand, the situation of the effect of influence factors was investigated by SEM, BET, XPS, and TG. It is revealed that reactive oxygen species are the key to catalytic ozonation and participate in catalytic oxidation of toluene as an electron transfer intermediate on active sites (Cux+-Ov-Mny+).
Effect of agricultural fiscal incentives on agricultural carbon intensity in China
Authors: Zhang Zhuang , Chen You-Hua , Tian Yun
Published: November 2022

Few studies provide direct evidence that agricultural fiscal affects agricultural carbon intensity, we try to fill this gap. Using panel data of 30 provinces in China from 2005 to 2019, we conclude that agricultural fiscal expenditures significantly reduce agricultural carbon intensity. The result is still robust after employing the provincial agricultural leaders’ birthplace information as an instrumental variable. Further study shows that the negative effect of agricultural fiscal expenditures on agricultural carbon intensity is more pronounced in regions with less corruption, and is also more visible in central, western and inland regions than other areas. For this effect, agricultural technological improvement and structure optimization are possible channels, but not operation scale expansion. Interestingly, although agricultural fiscal expenditures reduce the local agricultural carbon intensity, other regions' carbon intensity is increased due to fiscal rivalry.
HSP90 is a potential risk factor for ovarian cancer prognosis: an evidence of a Chinese clinical center
Authors: Duan Cancan , Li Kuokuo , Wei Zhaolian , Pan Xiaohua , Xiao Lan
Published: November 2022

Background: The potential treatment effects of heat shock protein90 (HSP90) inhibitors in ovarian cancer (OC) are controversial. This research aims to investigate the relationship between the expression level of HSP90 in peripheral blood and the prognosis of OC patients, as well as the clinicopathological indicators related to prognosis.
Materials and Methods: We retrospectively analysed the clinicopathological indicators of OC patients who were admitted to the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Anhui Medical University from 2017 to 2022. HSP90 expression in patient blood was detected by enzyme-linked immunosorbent assay, and the correlation between HSP90 expression and OC prognosis was systematically investigated. Kaplan-meier methodwas used to draw the survival curve, and the average survival time and survival rate were calculated. The log-rank test and Cox model were used for univariate survival analysis, and the Cox proportional hazards model was applied for multivariate survival analysis. Based on the TCGA dataset of OC obtained by Cbioportal, Pearson’s correlation coefficients between HSP90 expression values and other mRNA expression values were calculated to conduct bioinformatics analysis.
Results: According to the established screening criteria, 106 patients were selected as subjects. The enzyme-linked immunosorbent assay results showed that HSP90 was 50.94% overexpressed in patients with OC. According to the outcome of Kaplan–Meier curves, the results revealed that the high level ofHSP90 expression was suggested to poor prognosis (P = 0.000) of OC patients. Further more, the result of multivariate Cox proportional hazards regression model analysis also predicted that high HSP90 expression (HR = 3.498, 95% CI =1.431-8.551, P = 0.000) was leaded to poor prognosis,which could be an independent prognostic factor for the prognosis of OC patients. Moreover, 100 genes screened by Pearson’s value associated with HSP90, which is participate in regulating pathway of ATFS target genes, PRAGC1A target genes and BANP target genes and enriched in metabolic processesof cell response to DNA damage stimulus, response to heat and protein folding.
Conclusion: The overexpression of HSP90 is positively associated with OC mortality and is a potential prognostic indicator of OC.
The effect of Covid-19 pandemic lockdown on air pollutants levels within the Baghdad International Airport area in Iraq
Authors: Al-Mashhadani Sawsan , Al-Sharify Zainab , Kariem Nagam , Al-Moameri Harith , Al-Sharify Mushtaq Talib , Kaysi Nameer
Published: November 2022

Airports and the aviation industry cause regional and global environmental pollution due to their various activities. Therefore, improving the environmental performance has become a global challenge to giving high priority to environmental protection. This study measured and analyzed the essential air pollutants associated with aircraft movement in the Baghdad International Airport (BIA). Responsible for (77%) of the air traffic in Iraq, the largest and most important airport in Iraq, during the restart of the sector after stopping due to the Covid − 19 pandemic, and comparing them with local and global determinants, as well as comparing them with measurements made before the pandemic. The study dealt with selecting reference measurement sites recommended by the International Civil Aviation Organization (ICAO), where gases and particulates were measured in (12) external and internal sites, using advanced portable devices approved by the Iraqi Ministry of Health and Environment. Gases and molecular measurements were made for (45) flight operations, and (570) external and internal measurements were made, and concentrations of some parameters were recorded outside the permissible limits outside, such as: PM₁₀ = 215.8 µg/m3, TSP = 450.5 µg/m3, NO₂ = 3.01 ppm, SO2 = 0.76 ppm, O3 = 1.47 ppm, VOCS = 0.89 ppm, while internal measurements recorded the maximum concentrations at TSP = 21.2 µg/m3, NO₂ = 2.13 ppm, and O3 = 0.66 ppm. This calls for setting up fixed stations for continuous monitoring of air pollutants, conducting periodic checks and implementing the necessary treatments.
Endothelial cell-derived stem cell factor promotes lipogenesis through c-Kit-mediated upregulation of lipogenic enzymes in brown adipocytes
Authors: Koh Gou Young , Lee Hyuek Jong , Kim Young-Chan , Kim JungMo , Yang Myung Jin , Hong Seon Pyo , Lee Jueun , Hwang Geum-Sook
Published: November 2022

Thermogenic function of brown adipose tissue (BAT) has beneficial effects in metabolic diseases by utilizing lipids and glucose, whereas inactive BAT accumulates lipids in brown adipocytes (BAs), leading to BAT whitening. Although cellular crosstalk between endothelial cells (ECs) and adipocytes is important for fatty acid uptake in adipocytes, the roles of ECs in de novo lipogenesis (DNL) of adipocytes have been poorly understood. Using single-nucleus RNA sequencing and knock-out mice, we demonstrate that stem cell factor (SCF) from ECs promotes DNL by activating c-Kit in BAs. In the early phase of lipid accumulation induced by denervation or thermoneutrality, transiently expressed c-Kit on BAs upregulates DNL enzymes via PI3K and AKT signaling. EC-specific SCF deletion and BA-specific c-Kit deletion attenuate lipogenic enzymes and inhibit the enlargement of lipid droplets in BAs after denervation or thermoneutrality. These data provide insight into SCF/c-Kit signaling as a novel lipogenic regulator that promotes DNL in the early phase of lipid accumulation when thermogenesis is inhibited in BAT.
A unified platform for RNA-seq analysis in non-model species
Authors: Liu Peng , Ewald Jessica , Legrand Elena , Jeon Yeon-Seon , Sangiovanni Jonathan , Hacariz Orcun , Pang Zhiqiang , Zhou Guangyan , Head Jessica , Basu Niladri , Xia Jianguo
Published: November 2022

The increasing application of RNA-seq to study non-model organisms demands easy-to-use and efficient bioinformatics tools to help researchers quickly uncover biological and functional insights from large datasets. Here, we present a unified software suite for processing, analyzing, and interpreting RNA-seq data from any eukaryotic species. This suite consists of a) EcoOmicsDB (www.ecoomicsdb.ca), a database for ortholog mapping and cross-species comparison; b) EcoOmicsAnalyst (www.ecoomicsanalyst.ca), a platform for raw data processing and annotation; and c) ExpressAnalyst (www.expressanalyst.ca), a platform for statistical and functional analysis. The utilities of this suite are demonstrated through case studies of RNA-seq data from multiple non-model species with or without reference transcriptomes. By coupling ultra-fast read mapping algorithms with high-resolution ortholog databases through a user-friendly web interface, the tool suite enables researchers to obtain global expression profiles and gene-level insights from raw RNA-seq reads within 24 hours.
Clinical value of ultrasonic indicators in predicting the outcome of caesarean scar pregnancy after pregnancy termination
Authors: Fu Liye , Yuan Hongxia , Cao Hong , Zhou Qichang , Tan Xiaotan , Guo Jun
Published: November 2022

Objective: To investigate the predictive value of ultrasound indicators in early pregnancy for the outcome of caesarean scar pregnancy (CSP) after uterine clearance.
Methods: This study retrospectively analysed the ultrasound images of 98 patients with CSP who underwent uterine clearing during early pregnancy at Changsha Hospital for Maternal and Child Health Care, between January 2017 and October 2021. Patients were equally divided into a case group and a control group. The case group included 49 patients with CSP who had intraoperative blood loss ≥200 ml or retained products of conception (RPOC). The remaining 49 patients with CSP, with similar age and gestational age and no postoperative complications, were divided into the control group. Differences in ultrasound indicators between the case and control group were compared.
Results: There were significant differences between the case and the control group in the mean gestational sac diameter (MGSD), the thinnest muscle thickness between the gestational sac and the bladder, and the blood flow from the incision around the gestational sac (P< 0.05). Furthermore, the rs of each ultrasound indicator were as follows: 0.258, -0.485, 0.369. The receiver operating characteristic (ROC) curve analysis of the thinnest muscle thickness prediction of postoperative complications of the optimal threshold was 2.3 mm.
Conclusion: Thickness of the thinnest muscle and blood flow from the incision around the gestational sac have a low correlation with the postoperative complications of early pregnancy termination in patients with CSP, which can help predict the clinical outcome of patients with CSP.
Induction of tissue-specific premature stem cell aging via Lef1 deficiency promotes senescence-like deterioration in remote organs
Authors: Ikuno Yasuaki , Watanabe Koichiro , Kakeya Yumi , Ikeno Shinsuke , Nakabo Toshimasa , Narumoto Ayano , Kande Yukie , Hayashi Tomoki , Minami Kahori , Nobuhiro Kasumi , Mabuchi Yo , Nakamura Shiho , Okano Hideyuki , Ihara Dai , Katsuyama Yu , Naka-Kaneda Hayato
Published: November 2022

Molecular mechanisms of aging specific to each stem cell (SC) are being elucidated. However, the common molecular basis for senescence in various SCs remains largely unexplored. Here, we have shown that the dysregulation of DNA damage response (DDR) modulated by lymphoid enhancer-binding factor 1 (Lef1) and DDR-microRNAs (DDR-miRs) is the common molecular basis for aging in SCs. We identified Lef1as the most repressed transcription factor with aging in common between mesenchymal stem/stromal cells (MSCs) and hematopoietic stem/progenitor cells. Like the expression profiles of aged MSCs, Lef1 knockdown reduced broad microRNAs and loss of induction of DDR-miRs in young MSCs. DDR capacity was also diminished in aged SCs in vivo. Moreover, Lef1 deficiency in intestinal stem cells induced precocious dysregulation of DDR and inflammation and senescence in the remote brain. This study demonstrates that the Lef1/DDR-miR axis is the common molecular basis underlying SC aging.
Individuals with and without child maltreatment experiences are evaluated similarly and do not differ in facial affect display at zero-and first- acquaintance
Authors: Hautle Lara-Lynn , Kurath Jennifer , Jellestad Lena , Lüönd Antonia M. , Wingenbach Tanja S. H. , Frühholz Sascha , Jansson Billy , Niedtfeld Inga , Pfaltz Monique C.
Published: November 2022

Background
Individuals with child maltreatment (CM) experiences are more often disliked, rejected and victimized compared to individuals without such experiences. However, contributing factors for negative evaluations are so far unknown.
Objective
The purpose of this preregistered study, based on previous research on adults with borderline personality disorder (BPD), was to test whether negative evaluations of adults with CM experiences, in comparison to unexposed controls, are mediated by more negative and less positive facial affect display. Additionally, we explored whether level of depression, severity of CM, social anxiety, social support, and rejection sensitivity have an influence on ratings.
Methods
40 adults with CM experiences (CM+) and 40 non-maltreated (CM-) adults were filmed for measurement of affect display and rated in likeability, trustworthiness, and cooperativeness by 100 independent raters after zero-acquaintance (no interaction).
Results
Unexpectedly, the CM + and the CM- group were neither evaluated significantly different, nor showed significant differences in affect display. Contrasting previous research, higher levels of BPD symptoms predicted higher likeability ratings (p = .046), while complex post-traumatic stress disorder symptoms had no influence on ratings.
Conclusions
The non-significant effect could be attributed to insufficient number of participants, as our sample size allowed us to detect effects with medium effect sizes (f2 = .16 for evaluation; f2 = .17 for affect display) with a power of .95. Future research should further explore conditions (e.g., presence of specific mental disorders) under which individuals with CM are affected by negative evaluations as well as factors that contribute to negative evaluations and problems in social relationships.
Effects of 5/6 nephrectomy and high-protein diet on glomerular and tubular injuries in mice
Authors: Tanaka Shohei , Wakui Hiromichi , Azushima Kengo , Tsukamoto Shunichiro , Yamaji Takahiro , Urate Shingo , Suzuki Toru , Abe Eriko , Taguchi Shinya , Yamada Takayuki , Kobayashi Ryu , Kanaoka Tomohiko , Kinguchi Sho , Takiguchi Masahito , Funakoshi Kengo , Yamashita Akio , Ishigami Tomoaki , Tamura Kouichi
Published: November 2022

Numerous animal models of chronic kidney disease (CKD) have been developed. However, mice are relatively resistant to kidney injury. We aimed to evaluate the effects of high-protein diet (HPD) loading and 5/6 nephrectomy (Nx) in a susceptible strain of mice (129/Sv) over a long-term period. 129/Sv mice were divided into three groups: sham surgery (sham) + normal diet (ND) group, sham + HPD group, and 5/6 Nx + HPD group. Blood pressure, kidney function, and kidney tissue injury were compared longitudinally for 12 weeks among the three groups. The 5/6 Nx + HPD group displayed blood pressure elevation, kidney function decline, severe albuminuria, glomerular injury, and tubular injury compared with the sham + ND and sham + HPD groups. However, there was no significant difference in kidney injuries between the sham + ND and sham + HPD groups. Furthermore, the 5/6 Nx + ND group was added in comparison with the 5/6 Nx + HPD group. The glomerular injury was significantly exacerbated in the 5/6 Nx + HPD group than in the 5/6 Nx + ND group. These results indicate that HPD loading alone has little effect on kidney injury, while it exacerbates glomerular injury in the remnant kidney model.
Understanding the microstructure of a core-shell based anode catalyst layer for polymer electrolyte water electrolysis
Authors: De Angelis Salvatore , Schuler Tobias , Sabharwal Mayank , Holler Mirko , Guizar-Sicairos Manuel , Müller Elisabeth , Büchi Felix
Published: November 2022

Reducing precious metal loading in the anodic catalyst layer (CL) is indispensable for lowering capital costs and enabling the widespread adoption of polymer electrolyte water electrolysis (PEWE). This work presents the first three-dimensional reconstruction of a state-of-the-art TiO2-supported IrO2 based core shell catalyst layer (3 mgIrO2/cm2), using high-resolution X-ray ptychographic tomography at cryogenic temperature of 90 K. The high data quality and phase sensitivity of the technique have allowed the reconstruction of all four phases namely pore space, IrO2, TiO2 support matrix and the ionomer network, the latter of which has proven to be a challenge in the past. Results show that the IrO2 forms thin nanoporous shells around the TiO2 particles and that the ionomer has a non-uniform thickness and partially covers the catalyst. The TiO2 particles do not form a percolating network while all other phases have high connectivity. The analysis of the CL ionic and electronic conductivity shows that for a dry CL, the ionic conductivity is orders of magnitudes lower than the electronic conductivity. Varying the electronic conductivity of the support phase by simulations, reveals that the conductivity of the support does not have a considerable impact on the overall CL electrical conductivity.
Allometric options for predicting tropical tree height and crown area from stem diameter
Authors: Libalah Moses B. , Fayolle Adeline , Barbier Nicolas , Picard Nicolas , Momo Stéphane , Bocko Yannick , Mofack Gislain II , Katembo John Mukirania , Loumeto Joël , Yongo Olga Diane , Ngomanda Alfred , Couteron Pierre , Sonké Bonaventure , Vivien Rossi
Published: November 2022

Tree height and crown area are important predictors of aboveground biomass but difficult to measure on the ground. Numerous allometric models have been established to predict tree height from diameter (H–D) and crown area from diameter (CA–D). A major challenge is to select the most precise and accurate allometric model among existing ones, depending on the species composition and forest type where the model is to be applied. To propose a principle to select tree H–D and tree CA–D allometric models, we build a method based on k-fold cross-validation using a large dataset spanning six forest types from central Africa. We then compared the errors and biases using 22 previously established H–D and CA–D allometric model forms via three inter-comparable scenarios: locally derived for the forest type vs. regional vs. pantropical; regional (encompassing the forest type) vs. pantropical; regional (not encompassing the forest type) vs. pantropical model. H–D allometries were more variable across forest types in central Africa than CA–D allometries: (i) forest type explained 6% of the variance in H–D allometry and 2% of the variance in CA–D allometry, while species explained 9% and 2% of the variance in H–D allometry and CA–D allometry, respectively; (ii) for H–D allometry, the six forest types resulted in five best-fit models whereas, for CA–D allometry, four models provided the best fit for the six forest types. We recommend using allometric models specific to the forest type, preferentially to regional ones. Regional models should in turn be preferred to pantropical allometric models.
Biochemical characterization of abnormally softened sardine “soggy meat” during the spring spawning migration
Authors: Ito Mayu , Noda Ryouga , Honda Sigetaka , Matsuoka Yukari , Igura Ruki , Ueda Himawari , Kinoshita Kana , Yamashita Michiaki , Inoue Masayuki
Published: November 2022

“Soggy meat”, which is abnormally softened crushed sardine meat, is often detected in canned sardines seasoned with tomato chili sauce. As soggy meat represents lysed and decomposed tissue, we examined protease activity in the sardine meat during the spawning season. Abnormally soft sardine meat is often found in canned sardine meat from fish caught during the spring, and landed at Choshi Fishing Port in Japan, located on the Pacific Ocean. We measured cathepsin L activity in the muscle and protein, lipid, and moisture, as well as the trace elemental concentrations. High cathepsin L activity was detected in February and March during the Pacific sardine spawning season. In addition, 4 of 20 fish had extremely high protease activity of more than 30 unit/g . Cathepsin L activity in the muscle was negatively correlated with selenium, protein, and lipid concentrations, indicating that sardines in the spring were starving during their spawning migration. Therefore, starved physiological conditions during the spawning season may be responsible for soggy meat.