bluuebunny/crossref_metadata_2025 huggingface dataset:
Efecto jurídico del fallo de la Corte IDH en la competencia sancionadora de la Contraloría a funcionarios de elección popular
Authors: Sánchez Jiménez Fabián
Published: November 2022

El artículo de investigación trata el tema de los efectos jurídicos del fallo de la corte IDH en la competencia sancionadora de la Contraloría a funcionarios de elección popular. Se propone como objetivos, describir el procedimiento sancionatorio en Colombia de la Contraloría para con los funcionarios de elección popular, identificar el alcance de los planteamientos del fallo de la Corte IDH del 8 de julio de 2020 en el caso Petro vs. Colombia en relación con la competencia sancionadora de la Contraloría y establecer el efecto jurídico para Colombia en relación con la adecuación normativa y la facultad de los jueces penales para sancionar a funcionarios de elección popular.
Para lograr esto, se plantea una metodología de tipo cualitativa con enfoque descriptivo analítico, usando la revisión bibliográfica de estudios académicos sobre el tema, y fuentes primarias como el fallo de la Corte IDH sobre el caso Petro vs. Colombia con normatividad relacionada. Se espera analizar las consecuencias jurídicas relacionadas con la adecuación del ordenamiento interno a partir de dicho fallo de la Corte, de forma tal que los funcionarios de elección popular no puedan ser destituidos ni inhabilitados por decisiones de autoridades administrativas sin que eso implique un golpe a la estructura competencial, constitucional y legal del Estado Colombiano.
THE INFLUENCE OF VERTICAL INHOMOGENEITIES IN THE SOIL TOPLAYER, CAUSED BY THE EVAPORATION PROCESS, ON THE DIRECTIONAL CHARACTERISTICS OF AN ELEMENTARY EMITTER
Authors:   Omsk Scientific Center SB RAS, A. S. Yashchenko , K. V. Nemchanov ,   Omsk Scientific Center SB RAS
Published: November 2022

The results of estimating the directional characteristics of a quarter-wave monopole located near the surface of an inhomogeneous dielectric with losses are presented. During the simulation process, the Darcy and Maxwell equations were solved by the finite difference method. It is shown that a change in the view of the dielectric permittivity profile has a noticeable effect on the directional characteristics of the near-surface emitter. This results can be used in the process of estimate the directional characteristics of the emitting system.
A MODEL OF THE PROCESS OF GOAL PURSUIT BY OBJECTS PURSUING A GOAL BY THE CHASE METHOD
Authors:   D. Banzarov Buryat State Universit, A. A. Dubanov
Published: November 2022

This article describes the pursuit model by the method of chasing a group of objects. All objects participating in the pursuit model move at a constant modulo velocity. The pursuing object moves along a certain trajectory and releases objects at specified intervals, whose task is to overtake the target by the chase method. A single target, in turn, is tasked to overtake the pursuer by the method of parallel convergence. The task is to implement a dynamic model of multiple group harassment, where each object has its own tasks, its own strategies. The model is developed using computer mathematics systems. According to the results of the research, animated images were created. The research results may be in demand when designing unmanned aerial vehicles with elements of autonomous control and artificial intelligence.
THE CONCEPT OF SOLVING THE PROBLEM OF OPTIMIZING TECHNOLOGICAL REGIMES IN THE CONTROL OF PRIMARY OIL REFINING
Authors:   Tashkent State Technical University named after Islam Karimov, Sh. Gulomov , Ch. M. Khidirova ,   Tashkent University of Information Technologies named after Muhammad al-Khwarizmi, M. Doschanova ,   Tashkent University of Information Technologies named after Muhammad al-Khwarizmi
Published: November 2022

The article considers the problem of static optimization of the primary oil refining plant using an additive-separable function as an optimality criterion, reflecting the ratio of management costs and the beneficial effect of improving the quality and quantity of petroleum products.
LOCATION AN UNDESIRABLE FACILITY ON THE NETWORK WITH A RESTRICTION ON TRANSPORTATION COSTS
Authors:   Sobolev Institute of Mathematics SB RAS, G.G. Zabudsky ,   Dostoevsky Omsk State University
Published: November 2022

The article considers the formulation of the problem of location an facility on a network of roads connecting settlements. It is necessary to find the locations of the facility on each edge of the network in such a way that the sum of the weighted distances from it to all vertices is maximal (local maxima). At the same time, the specified amount should not exceed the budget for transportation costs for the maintenance of points. A polynomial algorithm for finding local maxima on each edge is proposed.
CREATION OF A MATHEMATICAL MODEL OF THE TECHNOLOGICAL PROCESS OF CLEANING COTTON FROM FINE PARTICLES AND DUST
Authors:   Namangan Civil Engineering Institute, Associate Professor of the Department of Informatics and Information Technology, S. Khashimov , N. D. Nuritdinov ,   Namangan Civil Engineering Institute, Associate Professor of the Department of Informatics and Information Technology, I. Makhamadzhanov ,   Namangan Civil Engineering Institute, Associate Professor of the Department of Informatics and Information Technology, S. Ergasheva ,   Namangan Civil Engineering Institute, Associate Professor of the Department of Informatics and Information Technology
Published: November 2022

Due to the fact that Uzbekistan has chosen a digital economy in its development strategy, it is necessary to modernize agriculture, digitalization, and develop technologies based on the production of highquality fiber at cotton spinning mills. In addition, a radical new approach to the operation of ginneries, the use of modern information technologies to eliminate contaminants in cotton through mathematical modeling and software to determine the optimal parameters of ginning equipment to improve fiber quality. This article describes a mathematical model for determining the parameters necessary for the normal operation of the considered cotton gin, on the basis of which a computational experiment was carried out and the values of the parameters were determined. The article developed a mathematical model of the movement of a piece of cotton on the surface of a vibrating mesh (separator), taking into account the factors affecting the process of cleaning cotton from small impurities and its application. Experimental studies were carried out on the basis of the developed program and methodology for determining the normal values of parameters that affect the efficient operation of the cotton gin device. Finally, by calculating the parameters of the device using the compiled programs and the computational experiment, results are obtained in which the lighting operations are displayed graphically in an appropriate way.
APPLICATION OF BIOMIMETIC LASER SHOCK PROCESSING TECHNOLOGY FOR HARDENING OF ALUMINUM ALLOYS
Authors:   Mechanical Engineering Research Institute of the Russian Academy of Sciences, G. Zh. Sakhvadze
Published: November 2022

The purpose of this work is to study the influence of the new technology of biomimetic laser shock processing (BLSP) in relation to samples made of aluminum alloy 2024-T351. The biomimetic parameters of BLSP are extracted from cherry leaves. Based on the extracted biomimetic parameters, a 3D finite element model (FEM) has been developed to study the effect of BLSP processing on the distribution of residual stress fields. The results obtained show that BLSP processing contributes to the formation of the so-called sandwich structure of the distribution of residual stresses in depth. It is shown that the residual stress field is divided into three layers: compressive residual stresses (CRS) are located on both surfaces, and tensile residual stresses (TRS) are located in the middle of the sample.
Molecular markers of recurrence of basal cell skin cancer
Authors: Saytburkhanov Rifat R. , Kubanov Alexey A. , Kondrakhina Irina N. , Plakhova Xenia I.
Published: November 2022

Basal cell carcinoma is the most common malignant neoplasm, andits incidence has been rapidly increasing worldwide. This malignancy is a serious public health problem that can lead to disability and severe aesthetic damage.
The results of the analysis of gene expression and proteomic profiling of tumor cells and the tumor microenvironment indicate that certain molecules involved in the pathogenetic pathways of basal cell skin cancer may represent new prognostic biomarkers or serve as the basis for their development.
The purpose of this review is to summarize information on known genes, proteins, and enzymes that can be used to diagnose, monitor therapy, and predict the course of basal cell skin cancer.
The PubMed, MedLine, Web of Science and RSCI databases were used to search for the necessary literature.
Determining the Level of Attachment to their Babies of Mothers Who Breastfeed Effectively and Think They Are Sufficient in Breastfeeding: A Cross-Sectional Study
Authors: GÜLER Nazan , AKKÖZ ÇEVİK Semra
Published: November 2022

Objective: This study aims to determine the relationship between breastfeeding success and breastfeeding self-efficacy and maternal infant attachment.

Methods: The study was conducted in xxx Family Health Center between March -June 2017. The questionnaire form, the LATCH Breastfeeding Identification and Assessment Scale, the Breastfeeding Self-Efficacy Scale, and the Maternal Attachment Inventory were used to collect data in the study. The Kruskall Wallis Analysis Mann, Whitney-U Analysis, Spearman Correlation and Kurtosis and skewness coefficients, Internal consistency Cronbach α coefficient were used in data analysis.

Results: The women who participated in the study had an average score of 9.87±0.42 in the LATCH Breastfeeding Identification and Assessment Scale, 63.51±10.71 in the Breastfeeding Self-Efficacy Scale and 101.58±2.28 in the Maternal Attachment Inventory. The difference between the average Breastfeeding Self-Efficacy Scores according to the level of education and time when breastfeeding started was statistically significant (p
Equipes virtuelles internationales et injonction à l’interaction
Authors: BRASSIER-RODRIGUES Cécilia
Published: November 2022

En examinant le projet mis en place entre deux établissements d’enseignement supérieur européens, nous cherchons à comprendre comment les équipes virtuelles internationales transforment la rencontre interculturelle entre étudiants porteurs de cultures différentes. L’analyse de 105 récits d’étudiants français montre que le projet a contribué au développement de leur sensibilité interculturelle. Elle révèle également le rôle joué par les interactions en ligne, dont le choix du fond et de la forme a été guidé par une rationalité communicationnelle orientée vers l’objectif à atteindre. Ce faisant, les étudiants ont développé des liens sociaux et appris à faire équipe à distance.
L’usage des technologies numériques éducatives dans l’enseignement supérieur africain : entre démocratisation de dispositifs et accentuation des inégalités socio-numériques
Authors: Maïdakouale Ibrahim , Fagadé Carole
Published: November 2022

La littérature portant sur les usages/non-usages des technologies numériques fait généralement état d’un manque de matériel, de pertinence ou d’intérêt pour certains dispositifs techniques. Or, à l’intérieur même des formations universitaires, qu’elles soient tout ou partiellement en distanciel, impliquant le recours aux techniques et réseaux numériques, des non-accès sont observés. Au sein des universités africaines, il existe en effet une fracture numérique qui sépare les étudiants disposant d’un capital économique et les étudiants issus des familles pauvres (sans emploi). Ceci a accentué les inégalités socio-numériques en contexte universitaire africain. La présente recherche, menée dans trois universités de trois pays de l’Afrique francophone auprès de 302 étudiants, interroge donc les causes et raisons des non-usages des dispositifs techniques chez les étudiants.
Le numérique au service de la valorisation des compétences des jeunes adultes
Authors: COVILLE Marion , RAMPNOUX Olivier , VÉTEL Bruno
Published: November 2022

Cette contribution questionne les modalités d’apprentissage des jeunes utilisateurs d’interfaces numériques. À la suite d'Auray (2016), nous analysons les aptitudes à maîtriser les environnements numériques, en discutant la typologie en 4 compétences qu’il propose. Parmi elles, nous nous focalisions surtout sur la compétence dite géographique. Elle regroupe 2 sous-compétences : topologique, une position d’action tactique réorientée de proche en proche et cartographique, une position d’action stratégique et surplombante envisagée en présence de connaissances exhaustives sur une situation. Pour mener ce travail comparatif, nous croisons les apprentissages inscrits dans deux domaines institutionnalisés : l’université et la santé. Des données empiriques issues de deux enquêtes menées dans ces contextes permettent de compléter l’analyse des inégalités sociales face au numérique par celle des handicaps cognitifs liés à l’autisme et physiques liés à des douleurs chroniques.
A Donor-Acceptor 10-Cycloparaphenylene and Its Use as an Emitter in an Organic Light-Emitting Diodes
Authors: Chen Dongyang , Wada Yoshimasa , Kusakabe Yu , Kayahara Ei-ichi , Sun Liangsheng , Suzuki Katsuaki , Tanaka Hiroyuki , Yamago Shigeru , Kaji Hironori , Zysman-Colman Eli
Published: November 2022

Here, we explored the possibility of using radial conjugated π-system of cycloparaphenylenes (CPP) within a donor-acceptor TADF emitter design. 4PXZPh-[10]CPP contains four electron-donating moieties connected to a [10]CPP. In the 15 wt% doped in CzSi film, 4PXZPh-[10]CPP showed sky-blue emission with λPL = 475 nm, ΦPL = 29%, and triexponential emis-sion decays with τPL of 4.4, 46.3 and 907.8 ns. Solution-processed OLEDs using 4PXZPh-[10]CPP exhibited sky-blue emission with an λEL of 465 nm and an EQEmax of 1.0%.
Body composition in sarcopenia in middle-aged individuals
Authors: Samoilova Iuliia G. , Matveeva Mariia V. , Khoroshunova Ekaterina A. , Kudlay Dmitrii A. , Tolmachev Ivan V. , Spirina Ludmila V. , Mosienko Igor V. , Yun Vera E. , Trifonova Ekaterina I. , Zakharchuk Polina I. , Vachadze Tamara D. , Shuliko Liudmila M. , Galiukova Daria E. , Mutalimi Venera E.
Published: November 2022

Sarcopenia is characterized by a progressive loss of muscle mass, strength, and function, leading to poor outcomes and reduced quality of life. In middle age, the decrease in muscle mass begins to be progressive. Bioimpedancemetry allows diagnosing this condition before the onset of clinical symptoms.
The purpose of the study: to evaluate the parameters of body composition in the early diagnosis of sarcopenia in middle-aged people.
Materials and Methods: The participants were divided into two groups the main one with sarcopenia 146 people and the control group 75 people. The complex of examinations included: neuropsychological testing (Hospital Anxiety and Depression Scale (HADS), quality of life questionnaire for patients with sarcopenia (SarQoL), short health assessment form (SF-36)), 4-meter walking speed test, dynamometry and bioimpedancemetry.
The results of neuropsychological examination did not differ in the main and control groups. Patients with sarcopenia showed a decrease in muscle strength according to dynamometry. The scores of the walking speed assessment test in the study group were significantly higher than in the control group. The main and control groups had excessive body weight. According to the results of bioimpedanceometry, the main group had increased fat mass, percentage of fat mass, visceral fat area, and fat mass index compared with the control group. Skeletal muscle mass was less in the main group, probable sarcopenia was confirmed by decreased appendicular mass, decreased protein and mineral content was also recorded. There was a more pronounced decrease in cell mass in the main group. In patients with sarcopenia the volume of intracellular and extracellular fluid was less than in the control group. Significant differences were considered at p0.05.
Conclusions: the introduction of bioimpedancemetry and dynamometry into early screening for muscle mass reduction will allow timely start of therapeutic and preventive measures even in middle age, which will lead to a decrease in the progression of sarcopenia in the elderly, as well as improve the quality of life.
The role of systemic immune activation in the development of thyroid dysfunction in COVID-19
Authors: Kolpakova Evgenia A. , Elfimova Alina R. , Nikankina Larisa V. , Troshina Ekaterina A.
Published: November 2022

Background. The research of cytokine-induced thyropathies in the midst of continuing coronavirus infection (COVID-19) pandemic is a very important and urgent problem. On the one hand, COVID-19 is often accompanied by a massive overproduction of cytokines, so we can expect an enhanced cytokines effects impact on the thyroid gland. On the other hand, it is possible that biological therapy with tocilizumab, which has a powerful immunosuppressive effect, plays a protective role to the development of cytokines-induced thyropathies amidst COVID-19. The results of the study should be the starting point for understanding the mechanisms of possible compromise of thyroid function during COVID-19.
Aim. The primary endpoint is to assess the relationship between the levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) with the inflammatory process markers. The secondary endpoint is the identification of an association between TSH, FT3 and FT4 values, and patient survival.
Materials and methods. This retrospective, single-center study included 122 patients hospitalized at the National Medical Research Center for Endocrinology with a clinical and laboratory analysis of COVID-19 and bilateral polysegmental viral pneumonia. To assess the functional status of the thyroid gland all patients underwent observation of the TSH, FT3, FT4, antibodies to thyroid peroxidase, antibodies to the TSH receptor (AT-recTSH). The markers of the inflammatory process were assessed: interleukin-6, C-reactive protein, the degree of lung tissue damage according to multispiral computed tomography of the lungs, the percentage of blood oxygen saturation (SpO2), the treatment outcomes.
Results. Five (4%) patients were found with subclinical thyrotoxicosis. Serum TSH values were inversely correlated with interleukin-6 (r=-0.221; p=0.024). Analysis of the level of hospital mortality, stratified by TSH, revealed statistically significantly lower TSH values in the group of deceased patients (p=0.012). The median TSH in surviving patients was 1.34 [0.85; 1.80], for the deceased 0.44 [0.29; 0.99].
Conclusion. Our research shows that the trigger of thyropathies in coronavirus infection is most likely thyroid tissue damage by the proinflammatory cytokines. This study shows some specific clinical aspects regarding the clinical relevance in patients with thyrotoxicosis and COVID-19, namely, the high hospital mortality rate.
Obesity and diabetes – are they always together?
Authors: Shestakova Marina V. , Shestakova Ekaterina A. , Sklyanik Igor A. , Stafeev Iurii S.
Published: November 2022

Obesity and type 2 diabetes mellitus (DM 2) are two interrelated metabolic diseases widespread throughout the developed world. However, up to 30% of individuals with a long history of obesity do not have a carbohydrate metabolism disorder. This article presents the results of a multi-year study of adipose tissue biology in obese individuals with DM 2 compared with individuals with the same history of obesity without DM 2. Comparative analysis of hormonal, cellular, and genetic factors in two groups of patients showed that DM 2 occurs in individuals with abnormal proliferation and adipogenic differentiation of mesenchymal stem cells (MSCs) of adipose tissue. It leads to adipocyte hypertrophy and inflammatory infiltration of adipose tissue macrophages, resulting in increased insulin resistance and diabetogenic effects. These disorders are due to abnormal expression of genes responsible for the proliferation and adipogenic differentiation of MSCs. The study of the possible reversibility of abnormal changes in adipose tissue MSCs in obese patients after significant weight loss and DM 2 remission appears to be a promising research direction. The ability to control adipose tissue progenitor cells may represent a new target for treating and preventing metabolic disorders in obesity.
Efficacy of Saccharomyces boulardii CNCM I-745 probiotic drug in the prevention and treatment of diarrhea in hospitalized patients with new coronavirus infection COVID-19
Authors: Maev Igor V. , Andreev Dmitry N. , Sokolov Philipp S. , Fomenko Aleksei К. , Devkota Mikhail K. , Andreev Nikolai G. , Zaborovsky Andrew V.
Published: November 2022

Aim. To evaluate the efficacy of Saccharomyces boulardii (S. boulardii) CNCM I-745 probiotic drug in preventing and treating diarrhea in hospitalized patients with COVID-19.
Materials and methods. A prospective comparative study was conducted in two parallel groups. The study included males and females aged 18 to 60 with the following diagnosis confirmed by polymerase chain reaction: U07.2 Coronavirus infection COVID-19, caused by SARS-CoV-2 virus (grade 13 pneumonia according to CT scan). All patients received antibiotic therapy. The patients were subdivided into two equal groups (n=60) depending on the administration of S. boulardii CNCM I-745 probiotic drug in addition to standard treatment. The probiotic was prescribed by the attending physician; the dose was 2 capsules per day (500 mg/day) 30 min before the meal for 10 days. All patients were monitored for main clinical, laboratory, and instrumental parameters during the study. In addition, the symptom of diarrhea (stool with a frequency of more than 3 times a day of type 6 and 7 according to the Bristol stool scale), including its frequency, duration, and the number of bowel movements of loose stool per day were precisely evaluated in both groups.
Results. In the overall patient pool, diarrhea was reported in 21.7% of in-patients during the observation period (95% confidence interval [CI] 14.229.1) with a mean duration of 4.6154 days (95% CI 3.7910-5.4398). The incidence of diarrhea in group 1 was 13.3% (95% CI 4.522.2), and in group 2, it was 30.0% (95% CI 18.141.9). Relative risk showed that the use of the S. boulardii CNCM I-745 probiotic drug leads to a significant reduction in the risk of diarrhea in hospitalized patients with COVID-19 infection receiving antibiotic therapy (odds ratio [OR] 0.3590, 95% CI 0.14210.9069; p=0.0303). In group 1, the duration of diarrhea was 3.1250 days (95% CI 2.58923.6608) versus 5.2778 days (95% CI 4.22906.3265) in group 2, p=0.0112. The mean daily frequency of loose stools in patients with diarrhea in group 1 was 3.2500 (95% CI 2.65883.8412) versus 4.3889 (95% CI 3.72525.0525) in group 2, p=0.0272. The secondary endpoint, duration of hospital stay, was also significantly shorter in group 1 patients 11.6833 days (95% CI 11.204212.1625) versus 12.7333 days (95% CI 12.135713.3309) in group 2, p=0.0120.
Conclusion. The present prospective comparative study demonstrated that adding S. boulardii CNCM I-745 probiotic drug into the standard treatment regimen of patients with new coronavirus infection COVID-19 receiving antibiotic therapy helps reduce the incidence of diarrhea and its severity during hospitalization, as well as the duration of hospital stay.
Management of a patient with diabetes mellitus after total pancreatectomy. Case report
Authors: Ametov Alexandr S. , Shabunin Alexey V. , Pashkova Evgeniya Y. , Amikishieva Ksenya A. , Golodnikov Ivan I. , Tavobilov Mikhail M. , Vlasenko Aleksey V. , Lukin Andrey Y.
Published: November 2022

In modern diabetology, the most important condition for a personalized approach to patient management is to determine the type of diabetes mellitus. Particular attention is drawn to a large, but at the same time insufficiently studied group of patients with diabetes mellitus due to diseases of the pancreas or as a result of surgical interventions on the pancreas, in particular, patients who, for a number of vital indications, undergo total pancreatectomy and the mechanism of development of impaired glucose homeostasis have not been studied in these patients. To date, there are no specific algorithms for managing this category of patients. This clinical example emphasizes that the management of glycemia in patients with diabetes mellitus as a result of total pancreatectomy is an extremely difficult task that requires a multidisciplinary approach in the treatment of this category of patients, the participation of an endocrinologist at all stages of patient treatment.
Sub-analyses of the DAPA-CKD study: new data on the use of sodium-glucose cotransporter type 2 inhibitor in the treatment of chronic kidney disease
Authors: Shamkhalova Minara S. , Sukhareva Olga Y. , Shestakova Marina V.
Published: November 2022

Sodium-glucose cotransporter inhibitors updated their position in the therapy of patients with type 2 diabetes mellitus due to proven nephro- and cardioprotective effects. The DAPA-CKD study, performed among individuals with CKD of various etiologies, was also conducted in a mixed population, including patients without type 2 diabetes, showed the ability of dapagliflozin to reduce the risk of the primary combined endpoint (eGFR15 ml/min/1.73 m2, the need for chronic dialysis or kidney transplantation, time to renal or cardiovascular death), and certain secondary endpoints. Due to the inclusion of dapagliflozin into the treatment of the patients with CKD of not only the diabetic origin and the expected subsequent significant expansion of the patient population with indications for the use of this drug, the review of the results of the sub-analyses of DAPA-CKD study may be of interest to the clinicians.
Adipokines and the cardiorespiratory system in young patients with type 1 diabetes mellitus
Authors: Vengrzhinovskaya Oksana I. , Bondarenko Irina Z. , Shatskaya Olga A. , Nikankina Larisa V. , Kalashnikov Viktor Y. , Shestakova Marina V. , Mokrysheva Natalia G.
Published: November 2022

Early screening of complications of diabetes mellitus (DM) is one of the priorities for public health. Most patients with type 1 diabetes mellitus (T1DM) are patients of working age. New strategies for the primary prevention of cardiovascular disease (CVD) are needed to prevent their early disability.
Aim. To assess the predictive value of adipokines in relation to a personalized approach to the need for an in-depth examination of young patients with T1DM.
Materials and methods. The study included 98 patients without CVD: 70 patients with T1DM (mean age 26.48.1 years) and 28 patients without DM (mean age 279 years). All patients underwent a general clinical examination, the levels of adipokines were determined, ergospirometry, echocardiography, and bioimpedancemetry were performed.
Results. Changes in the cardiorespiratory system in patients with T1DM were revealed, in comparison with persons without T1DM: anaerobic threshold was reached faster (p=0.001), maximum oxygen consumption was lower (p=0.048), metabolic equivalent was reduced (p=0.0001). Signs of myocardial remodeling were found in the T1DM group: there was an increase in the relative wall thickness (p=0.001), the posterior wall of the left ventricle (p=0.001), myocardial mass index (p=0.049), in comparison with persons without T1DM. Changes in the adipokines system were revealed: higher levels of resistin (p=0.002) and visfatin (p=0.001), lower level of adiponectin (p=0.040) in T1DM. A positive correlation was found between posterior wall of the left ventricle and visfatin (p=0.014) and a negative relationship between adiponectin and relative wall thickness (p=0.018) in T1DM.
Conclusion. In T1DM, even at a young age, there are multifactorial changes in the heart, which can be detected even at the preclinical stage. The data obtained can be used to identify groups of patients at high risk of developing dangerous CVD in T1DM, which can form the basis for determining the timing of the start of preventive therapy.
ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma
Authors: Ferrarese Roberto , Izzo Annalisa , Andrieux Geoffroy , Lagies Simon , Bartmuss Johanna Paulina , Masilamani Anie Priscilla , Wasilenko Alix , Osti Daniela , Faletti Stefania , Schulzki Rana , Yuan Shuai , Kling Eva , Ribecco Valentino , Heiland Dieter Henrik , Tholen Stefan , Prinz Marco , Pelicci Giuliana , Kammerer Bernd , Boerries Melanie , Carro Maria Stella
Published: November 2022

Enhanced fatty acid synthesis is a hallmark of tumors, including glioblastoma. SREBF1/2 regulate the expression of enzymes involved in fatty acid and cholesterol synthesis. Yet, little is known about the precise mechanism regulating SREBP gene expression in glioblastoma. Here, we show that a novel interaction between the co-activator/co-repressor CTBP and the tumor suppressor ZBTB18 regulates the expression of SREBP genes. In line with our findings, metabolic assays and glucose tracing analysis confirm the reduction in several phospholipid species upon ZBTB18 expression. Our study identifies CTBP1/2 and LSD1 as co-activators of SREBP genes and indicates that the functional activity of the CTBP-LSD1 complex is altered by ZBTB18. ZBTB18 binding to the SREBP gene promoters is associated with reduced LSD1 demethylase activity of H3K4me2 and H3K9me2 marks. Concomitantly, the interaction between LSD1, CTBP, and ZNF217 is increased, suggesting that ZBTB18 promotes LSD1 scaffolding function. Our results outline a new epigenetic mechanism enrolled by ZBTB18 and its co-factors to regulate fatty acid synthesis that could be targeted to treat glioblastoma patients.
DEMOCRACY AS A PUBLIC IDEAL AND POLITICAL PRACTICE
Authors: Martsikhiv Khrystyna , Seliverstova Kateryna
Published: November 2022

The multifaceted democratic processes in modern political science are considered, which are reduced to a number of theoretical concepts related to defining the essence of the concepts of «democracy», people’s «freedom of speech», various concepts of democracy.

The basic goals and principles of democracy formation, which are very important in the modern world, are studied and defined, because the value of democracy in the 21st century is not only that it makes it possible to establish the effective rule of law. Emphasis is placed on the values of democracy in its inner essence. The importance of democracy is argued because it embodies the idea of equality and freedom, the idea of human and individual dignity, the idea of the right to choose for everyone, the possibility of exercising the right to vote for the formation of a government that would take into account the interests of voters.

The constituent features of democracy are analyzed, in particular the criteria which allow to define this or that state as democratic; the basic principles of democracy and its certain levels are considered; specific examples of the democracies formation, taking into account their national characteristics, as well as ways to control citizens over the political decision-making process, which can promote or hinder the achievement that will contribute to true freedom and equality of citizens in the state.
"Listen to Irene Cara", "Octavio Paz and the Nobel", "The Goals of Diego Maradona"
Authors: Blackman Shane
Published: November 2022

These 3 sonnets explore the lives of pop-star Irene Cara, author and Nobel Prize winner Octavio Paz, and soccer legend Diego Maradona. Though one major sonnet form from literary history has included iambic pentameter, the sonnets here drop the iambic part, but keep the pentameter. In the history of the sonnet, there traditionally have been rhyme schemes. There is no particular rhyme scheme in these 3 sonnets. They are written with a mixture of free verse and rhyming. The poems span across Latin America -- from Mexico to Argentina and from Cuba to Puerto Rico -- and they celebrate the rich musical, literary, and sporting worlds of three icons and legends. The 3 sonnets employ ordinary language to describe extraordinary people, so that everyone and all readers can be inspired to be creative and to enjoy, shape, and impact the world.
Politics of Dismissal and Death: Tentacle, Necropolitics, and the Political Subject
Authors: Duncan Teddy
Published: November 2022

In Rita Indiana’s novel, Tentacle, the future of the Dominic Republic is postulated as bleak and dystopian: a nuclear ecological disaster has nearly ruined the ocean, colorism and racism are pervasive, Haitians are indiscriminately executed due to an unnamed “virus” (Indiana 3), and historical class divisions, as well as wealth inequalities, are maintained. The various issues that Indiana’s future-oriented Dominican Republic is facing emerge from political contingencies: they are the result of clear choices facilitated by the political leaders of the Dominican Republic. Yet, while the text renders historical reality as contingent and liable to change, it also explicitly points out the limits of individual agency and action. Tentacle demonstrates the politico-ontological dismissal of subjects that is enacted through necropolitics. The text also recognizes the contingent nature of political formation and necropolitics, and by doing so, implicitly contests the essentialization of formerly colonized countries such as the Dominican Republic. Ultimately, I argue that the precarity of the political subject and the material-political-reality are not depicted in Tentacle as necessary or inevitable parts of some dialectic process of progression, but rather as potentially preventable or intervenable processes that evade individual agency.
ПРОБЛЕМИ ТА НЕОБХІДНІСТЬ «ЗЕЛЕНОГО ФІНАНСУВАННЯ» У ПОВОЄННИЙ ПЕРІОД ВІДБУДОВИ ЕКОНОМІКИ УКРАЇНИ
Authors: Karlin Mykola , Prots Natalia
Published: November 2022

Війна Росії проти України принесла значні втрати для економіки, довкілля та громадян нашої країни, що вимагає розробки відповідного механізму компенсації цих втрат. Важливим елементом цього механізму повинна стати розробка системи заходів щодо «зеленого фінансування» відбудови Української держави. В статті розкриті особливості «зеленого фінансування» відбудови економіки України після війни з Росією та напрямів дотримання нормативних документів ЄС в цьому процесі. Основними завданнями статі є визначення основних проблем «зеленого фінансування» в Україні у відбудовний період та виявлення шляхів їх подолання.
Perilaku Konsumtif Produk Kosmetik ditinjau dari Konsep Diri pada Mahasiswi
Authors: Khoiriyah Siti Febiyanti , Hakim Zun Azizul
Published: November 2022

The aim of this research is to explore the impact of self concept on cosmetic consumtif behavior in female students. This exploration utilizes quantitative strategies with causal comparative approach. Participant of this study consist of 118 female undergraduate students. The hypothesis was analized using regression technique, with SPSS. The results of this study indicate the value of the regression coefficient of r = -0.323 with a significant level of 0.008 (p <0.05) meaning that there is a significant influence of self-concept on consumptive behavior, in a negative direction. This result means that the higher the self-concept owned by the female student, the lower the consumptive behavior of purchasing cosmetics. This study recommends efforts to get good self-concept to reduce consumptive behavior.
Rendimiento y resistencia al mosaico amarillo dorado de genotipos de frijol negro tropical
Authors: Tosquy-Valle Oscar Hugo , Villar-Sánchez Bernardo , Ibarra-Perez Francisco Javier , Anaya-López José Luís , Garrido-Ramírez Eduardo Raymundo
Published: November 2022

En las áreas tropicales de Chiapas, México, la producción de frijol es afectada por el mosaico amarillo dorado, la sequía y la acidez de los suelos. El objetivo de esta investigación fue identificar genotipos de frijol resistentes al mosaico amarillo dorado, con mayor productividad que la variedad Negro Jamapa, comúnmente sembrada en Chiapas. En otoño-invierno de 2019-2020 se estableció un experimento en tres localidades del centro de Chiapas, se evaluaron 11 líneas y tres variedades de frijol negro, incluida Negro Jamapa. El diseño experimental fue bloques al azar con tres repeticiones. Se cuantificó la incidencia de mosaico amarillo dorado y el rendimiento de grano. Los datos de las tres localidades se analizaron de manera individual y combinada. También se realizaron análisis de correlación entre la incidencia de mosaico amarillo dorado y el rendimiento de los genotipos. El mosaico amarillo dorado redujo el rendimiento en los tres sitios de evaluación (Villa Corzo, r= -0.562*; CECECH, r= -0.757** y El Gavilán, r= -0.552*). La línea Jamapa Plus/XRAV-187-3-4-1 mostró los mayores daños por esta enfermedad con una calificación promedio de incidencia de 6, significativamente superior al resto de los genotipos; en tanto que, las líneas: Negro Citlali/XRAV-187-3-1-6, Papaloapan/SEN 46-7-7 y Jamapa Plus/XRAV-187-3-4-4 y la variedad Verdín mostraron la mayor resistencia al mosaico amarillo dorado, con calificaciones de incidencia de entre 1.67 y 3.22, estadísticamente inferiores a la del testigo Negro Jamapa. Estos cuatro genotipos también obtuvieron rendimientos promedio significativamente sobresalientes (mayores a 934 kg ha-1) y superiores al de Negro Jamapa.
Efecto de densidades de población sobre crecimiento y rendimiento de hule en Veracruz
Authors: Ortiz-Cervantes Elías , Hernández-Cruz José Miguel , Moctezuma-López Georgel
Published: November 2022

En México, el rendimiento promedio anual de hule (Hevea brasiliensis [Willd. ex A. Juss] Muell. Arg.) es inferior a 1.2 t ha-1, mediante la optimización de la densidad de población se busca aumentar el rendimiento y productividad. El trabajo se realizó en la región central del estado de Veracruz. Se evaluaron los arreglos de plantación 4x2, 6x3 (testigo), 8x4 y 10x5 m, con densidades de 1 250, 556, 312 y 200 árboles ha-1, respectivamente. El diseño experimental fue bloques al azar con cuatro repeticiones y 40 árboles del clon IAN-754 por unidad experimental. Las principales variables evaluadas fueron circunferencia del tallo, rendimiento de hule y rendimiento de biomasa. Al séptimo año, se obtuvo que a mayor densidad menor porcentaje de árboles aptos para extraer látex (circunferencia del tallo >45 cm). La circunferencia del tallo al final del periodo osciló entre 67 y 120 cm, a mayor densidad hubo menor crecimiento y mayor cantidad de árboles suprimidos. A mayor densidad se obtuvo menor rendimiento en gramos por árbol por pica de hule, pero mayor rendimiento en kg ha-1 año-1, con una oscilación entre 960 y 2 040 kg. La biomasa total por árbol osciló entre 223 y 924 kg y la biomasa total por hectárea entre 158 y 240 t ha-1. Además, con densidades de población más altas el rendimiento de hule fue mayor y con 556 árboles se logró mejor balance.
Mapeo de QTL en línea Mutus#1 de trigo resistente a la mancha foliar
Authors: Sánchez-Vidaña Mariel del Rosario , Vargas-Hernández Mateo , He Xinyao , Paola Sansaloni Carolina , Kumar-Singh Pawan , Hernández-Anguiano Ana María
Published: November 2022

La mancha foliar del trigo causada por Zymoseptoria tritici es una enfermedad devastadora en el cultivo de trigo a nivel internacional. El control químico y el uso de variedades resistentes son las principales estrategias de control. El Centro Internacional de Mejoramiento de Maíz y Trigo (CIMMYT), cuenta con líneas de trigo con resistencia cuantitativa a la enfermedad por lo que el objetivo fue hacer un mapeo de loci para un carácter cuantitativo (QTL) asociados con la resistencia genética a la mancha foliar en la línea élite Mutus#1 (resistente), en una población de 275 líneas endogámicas recombinantes (LER) derivadas de la cruza de Mutus#1 con la línea élite Huirivis#1 (susceptible). En 2018 y 2019, en la estación del CIMMYT-Toluca se estableció un experimento en campo bajo un diseño experimental Alpha Lattice. Se generó una epidemia artificial con Z. tritici y se calculó el área bajo la curva del progreso de la enfermedad (ABCPE). Las 275 LER y los progenitores se secuenciaron utilizando la plataforma DArTSeq. Los mapas de ligamiento se construyeron con el programa IciMapping empleando la información del fenotipo y genotipo. Se identificaron cinco QTL de efecto menor, tres ubicados en los cromosomas 1B, 4A y 4B y dos en el cromosoma 5B, los cuales explicaron menos de síntomas y producción de picnidios en planta adulta portados por Mutus#1, pueden utilizarse con otros genes de resistencia o QTL para reducir la selección de nuevas cepas patogénicas de Z. tritici.
Simulação computacional aplicada a modulação de transmissão de sinal e processamento digital de imagem
Authors: Aleixo Leonardo Guimarães
Published: November 2022

Estudo desenvolvido de modelo matemático para detectar probabilidade de erros na transmissão de sinais em telecomunicações, com aplicação de métodos por integração analítica aproximada em conjunto a valores de resposta numérica computacional. A curva matemática da equação proposta ´e comparada aos resultados retornados pela função Python de distribuição cumulativa estatística norm.cdf, com apresentação de curvas gráficas dentro de intervalo determinístico, e retornando valores numéricos aproximados aos da tabela Q(x) utilizada em engenharia de telecomunicações. Ao final, o modelo matemático desenvolvido ´e aplicado como nova função de filtragem de sinal no processamento de uma imagem digital.
EDUCAÇÃO, TECNOLOGIA E INCLUSÃO: Desafios antigos e contemporâneos
Authors: Costa Hérika Cristina Oliveira da , Nunes Camila da Cunha , Dalcastagner Graziela Boaszczyk , Santos Leonardo Simões dos , Azevedo Suziane Antunes , Mesquita Amélia Maria Araújo , Veiga Maria Aparecida , Agostini Taise , Anchieta Gabrielle Oliveira dos Santos , Ischkanian Simone Helen Drumond , Cabral Gladys Nogueira , Souza Alcione Santos de , Moraes Maria Isabel da Silva , Ischkanian Sandro Garabed , Carvalho Gabriel Nascimento de , Odilon Jayme Salz , Silva Amanda Jeniffer da Silva e , Ronque Wanessa Delgado da Silva , Lima Adriana Alves de , Duque Rita de Cássia Soares , Silva Diogo Rafael da , Drumond Eliana , Silva Taynan Alécio da , Ferreira Juliana Balta , Ferrari Patrícia Augusto , Andrade Emanuel Adeilton de Oliveira , Nascimento Alice Dayse da Silva , Carapuça Maria José Ribeiro , Souza Juliana Cristina Paulista da Silva
Published: November 2022

O livro possui foco nas práticas pedagógicas conduzidas pelos autores, baseada nos preceitos da interatividade, na partilha de saberes, nas trocas de experiências e no respeito às diferenças.
Ensino de ciências para estudantes com deficiência intelectual e os usos de espaços não formais
Authors: Souza Mariana Paganott Rodrigues de , Araújo Márcia Moreira de
Published: November 2022

Os alunos com deficiência demandam o desenvolvimento de propostas educativas e metodologias que tenham em conta os seus interesses, que lhes permitam explorar a curiosidade e imaginação, tornando possível uma visão crítica, reflexiva e participativa frente ao seu processo educativo e frente à sua vida. Por isso, essa publicação assume uma proposta educacional que visa o fortalecimento de conceitos, atitudes, hábitos e promoção da sensibilidade dos estudantes, por meio de sugestões de atividades que envolvem a vida cotidiana e fazem parte dos currículos de ciências, facilitando sua participação com atividades por meio dos sentidos, permitindo um enriquecimento da sua formação e atendendo às suas necessidades.
Beneficial effects of a ketogenic diet in a woman with Charcot-Marie-Tooth disease
Authors: Elvira Rostanzo , Anna Maria Aloisi
Published: November 2022

Objective: To evaluate the effects on quality of life and body composition of a Ketogenic Diet (KD) in a woman with Charcot-Marie-Tooth (CMT) disease. Methods: Physical (PCS) and mental (MCS) health conditions were evaluated with the SF-36 questionnaire; dual-energy x-ray absorptiometry was used to determine body composition; parameters were determined at baseline and after 12 weeks of KD. Results: At baseline PCS and MCS were 20.6 and 20.7 respectively with 37.9% fat mass. After 12 weeks SF-36 values significantly improved: PCS 55 and MCS 66.1 with 33.9% fat mass. Conclusion: KD improved the patient’s quality of life and decreased fat mass. Further studies will be needed to better elucidate the beneficial effects of KD among people with CMT.
The Issues of Academic Literacy in Conversation Practice During Online Learning
Authors:   University of Muhammadiyah Tangerang, Arjulayana Arjulayana , Rachmi Rachmi ,   Universitas Pembangunan Nasional Jakarta
Published: November 2022

University students are required to be more independent in the learning process, this is because university students already have greater responsibilities, both in terms of following the campus’ rules where they study, as well as in terms of discipline in doing assignments as students. Low academic literacy will result in not achieving responsibilities and learning objectives, campus facilities, student abilities, and lecturer competencies. This study aims to investigate the issues of academic literacy faced by students and lecturers during online learning. The sample of this study was 40 first-semester students from the University of Muhammadiyah Tangerang, Visual Communication Design study program. The instrument of the research is observation, interview, and document study based on student learning outcomes. In conclusion, the first result of this study indicates that the use of technological facilities has not been utilized optimally by students in the effort of improving their knowledge, self-awareness, creativity, and initiative to support their understanding and represent their academic literacy practice. The second result indicates that the facilities provided by the campus are not optimal to support students studying online, through the disclosure of university information that can be accessed at any time on the website, such as exam schedules, academic events, competitions, festivals, and other campus activities. The third result shows that students’ conversation practice during online learning can run well, due to clear instruction from the lecturer and conversation partners cooperatively
İKİ SADAKAT ARASINDA; ABDULLAH QUILLIAM VE MUHAMMED M. PICKTHALL
Authors: KAHRAMAN Kemal
Published: November 2022

19 yy. da İngiltere Ortadoğu politikalarında en önemli aktörler arasındadır. Yüzyılın ortalarına doğru ülkede Rus yayılmacılığına karşı Osmanlı yanlısı kuvvetli bir rüzgar esmiştir. Buna bağlı olarak İngiliz aydınları arasında Osmanlı devletine dost cemiyetler oluşmuş, yayınlar yapılmıştır. İslam coğrafyasıyla temaslar sonucu Müslümanlığı seçen bir grup ortaya çıkmıştır. Abdullah Quilliam bu anlamda ilk akla gelen isimdir. Liverpool’lu bir avukat olan Quilliam İngiltere’de ilk İslam merkezini kurmuştur. Osmanlı ile yakından ilgilenmiş, Sultan II. Abdülhamid tarafından bizzat kabul edilerek İngiltere’nin ilk ve tek şeyhülislamı olmuştur. Yazıları ve faaliyetleriyle yüzlerce İngiliz’in Müslüman olmasını sağlamıştır. Kendisinden 19 yaş küçük olan Muhammed M. Pickthall da dönemin ünlü bir İngiliz Müslüman aydınıdır. Genç yaşta Ortadoğu’ya giderek Arapça öğrenmiş, Osmanlı coğrafyası üzerine hikayeler, romanlar yazmıştır. Osmanlı devletinin parçalanmaması için elinden geleni yapmıştır. Bir yandan Hint Hilafet hareketine katılmış, bir yandan Jön Türkler ve İttihatçılara umut bağlamıştır. Son Osmanlı Sadrazamı Sait Halim Paşa ile bizzat görüşmüş, düşüncelerinden etkilenmiştir. Çeşitli ortamlarda Quilliam’la karşılaşmıştır. Hayatlarında, faaliyetlerinde, İslam dünyasına ve Osmanlı’ya bakışlarında önemli paralellikler ve farklar söz konudur. Bu çalışmanın amacı, iki İngiliz aydın arasındaki benzerlik ve farkları ana hatlarıyla ortaya koymaktır.