bluuebunny/crossref_metadata_2025 huggingface dataset:
A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy
Authors: Bellanca Carlo Maria , Augello Egle , Di Benedetto Giulia , Burgaletto Chiara , Cantone Anna Flavia , Cantarella Giuseppina , Bernardini Renato , Polosa Riccardo ,   the DiaSmokeFree Working Group
Published: June 2024

Currently 1.3 billion individuals globally engage in smoking, leading to significant morbidity and mortality, particularly among diabetic patients. There is urgent need for a better understanding of how smoking influences antidiabetic treatment efficacy. The review underscores the role of cigarette smoke, particularly polycyclic aromatic hydrocarbons (PAHs), in modulating the metabolic pathways of antidiabetic drugs, primarily through the induction of cytochrome P450 (CYP450) enzymes and uridine diphosphate (UDP)-glucuronosyltransferases (UGTs), thus impacting drug pharmacokinetics and therapeutic outcomes. Furthermore, the review addresses the relatively uncharted territory of how smoking cessation influences diabetes treatment, noting that cessation can lead to significant changes in drug metabolism, necessitating dosage adjustments. Special attention is given to the interaction between smoking cessation aids and antidiabetic medications, a critical area for patient safety and effective diabetes management. This scoping review aims to provide healthcare professionals with the knowledge to better support diabetic patients who smoke or are attempting to quit, ensuring tailored and effective treatment strategies. It also identifies gaps in current research, advocating for more studies to fill these voids, thereby enhancing patient care and treatment outcomes for this at-risk population.
Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy in Chlamydomonas reinhardtii
Authors: Chen Jing , Chen Yuanhao , He Weiling , Liang Honghao , Hong Ting , Li Tangcheng , Du Hong
Published: June 2024

Background

The green alga Chlamydomonas reinhardtii can grow photoautotrophically utilizing light and CO2, and heterotrophically utilizing acetate. The physiological and biochemical responses of autotrophy and heterotrophy are different in C. reinhardtii. However, there is no complete understanding of the molecular physiology between autotrophy and heterotrophy. Therefore, we performed biochemical, molecular and transcriptome analysis of C. reinhardtii between autotrophy and heterotrophy.

Results

The cell growth characterization demonstrated that heterotrophic cell had enhanced growth rates, and autotrophic cell accumulated more chlorophyll. The transcriptome data showed that a total of 2,970 differentially expressed genes (DEGs) were identified from photoautotrophy 12h (P12h) to heterotrophy 12h (H12h). The DEGs were involved in photosynthesis, the tricarboxylic acid cycle (TCA), pyruvate and oxidative phosphorylation metabolisms. Moreover, the results of qRT-PCR revealed that the relative expression levels of malate dehydrogenase (MDH), succinate dehydrogenase (SDH), ATP synthase (ATPase), and starch synthase (SSS) were increased significantly from P12h and H12h. The protein activity of NAD-malate dehydrogenase (NAD-MDH) and succinate dehydrogenase (SDH) were significantly higher in the H12h group.

Conclusion

The above results indicated that the high growth rate observed in heterotrophic cell may be the effects of environmental or genetic regulation of photosynthesis. Therefore, the identification of novel candidate genes in heterotrophy will contribute to the development of microalga strains with higher growth capacity and better performance for biomass production.
Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial
Authors: Worthen-Chaudhari Lise , Schnell Patrick M. , Hackney Madeleine E. , Lustberg Maryam B.
Published: June 2024

Introduction

Dance has been proposed to support superior intrinsic motivation over non-dance forms of therapeutic physical activity. However, this hypothesis has yet to be evaluated empirically, particularly among populations living with neuropathology such as survivors of cancer with neurologic complications from chemotherapy treatment. Questions about motivation are relevant to clinical outcomes because motivation mediates neuroplasticity. We conducted this secondary analysis of a randomized-controlled study to begin to investigate the relationships between personal motivation and neurophysiologic effects of dance-based intervention for healthy aging among populations with neurologic complications of cancer.

Methods

We measured motivation using the Intrinsic Motivation Inventory, a validated patient-reported outcome from the psychological approach of Self Determination Theory. We assessed intrinsic motivation, extrinsic motivation, and satisfaction with intervention within a randomized controlled trial of dance versus exercise designed to alleviate symptoms of chemotherapy-induced impairment. Fifty-two survivors of breast cancer with chemotherapy-induced neuropathy diagnosis and associated sensorimotor functional deficits were randomized (1:1) to 8 weeks of partnered dance or home exercise, performed biweekly (NCT05114005; R21-AG068831).

Results

While satisfaction did not differ between interventions, intrinsic motivation was higher among participants randomized to dance than those randomized to exercise (p < 0.0001 at all timepoints: 2 weeks, 4 weeks, 6 weeks, and 8 weeks of intervention), as was extrinsic motivation at 2 weeks (p = 0.04) and 8 weeks (p = 0.01).

Discussion

These data provide evidence that social dance is more motivating than the type of home exercise generally recommended as therapeutic physical activity. The results inform directions for future study of the effect of dance-based therapeutics on embodied agency, neuroplastic changes, and clinically-relevant neuropathic improvement.
Factors affecting parental role adaptation in parents of preterm infants after discharge: a cross-sectional study
Authors: Li Jia , Zhang Xiaohong , Ye Fei , Cheng Xiaolin , Yu Liping
Published: June 2024

Background

Parenting a preterm infant can be incredibly challenging and stressful, particularly in the first year after discharge. Desirable parental role adaptation leads to appropriate parenting behaviors and parent-infant interaction, which are essential to child health and development.

Aim

To investigate the level of parental role adaptation and its influencing factors among parents of preterm infants in the first year after hospital discharge according to Belsky’s parenting process model among parents of preterm infants in the first year after hospital discharge.

Methods

A cross-sectional study design was adopted using convenience sampling. Data were collected using the Parental Role Adaptation Scale (PRAS) in parents with preterm infants, the Perceived Social Support Scale (PSSS), the Coping Adaptation Processing Scale (CAPS-15), and a sociodemographic questionnaire. Descriptive statistics, non-parametric tests, Spearman correlation analyses, and multivariate linear regression were used to analyze the data.

Results

In total, 300 Chinese parents were included in the analysis. In the multivariate analysis, first-time parent (p = 0.003), master’s degree and above (p = 0.042), coping adaptation processing (p = 0.000), residence location (towns: p = 0.019, city: p = 0.028), monthly family income (6000–10,000: p = 0.000, >10,000: p = 0.000), and perceived social support (p = 0.001) were all significant predictors of parental role adaptation and collectively accounted for 56.8% of the variation in parental role adaptation of parents with preterm infants (F = 16.473, p < 0.001). Coping adaptation processing mediated the relationship between perceived social support and parental role adaptation (95% bootstrap CI = 0.022, 0.130).

Conclusion

Chinese parents of preterm infants experience a moderate level of parental role adaptation when their child is discharged from the hospital to home. Parents who are not first-time parents, have master’s degrees or above, live in towns or cities, have higher coping and adaptation abilities, have high monthly family income, and greater perceived social support have a higher level of parental role adaptation. Healthcare providers should pay more attention to parents with low socioeconomic status and encourage them to improve their coping and adaptation abilities and to utilize their formal and informal social support networks.
Investigating the causal association between gut microbiota and type 2 diabetes: a meta-analysis and Mendelian randomization
Authors: Liu Ting , Cao Yang , Liang Ning , Ma Xiaoqi , Fang Jing-ai , Zhang Xiaodong
Published: June 2024

Background

Studies have shown that gut dysbiosis contributes to the pathophysiology of type 2 diabetes mellitus (T2DM). Identifying specific gut microbiota dysbiosis may provide insight into the pathogenesis of T2DM.

Purpose

This study investigated the causal relationship between gut microbiota and T2DM using meta-analysis and Mendelian randomization (MR).

Methods

In the first part, we searched for literature on gut microbiota and T2DM, and conducted a meta-analysis. We observed differences in glycosylated hemoglobin and fasting blood glucose levels in both groups. Second, we obtained GWAS data from genome-wide association study database 19 (GWAS). We used two-sample MR analysis to verify the forward and reverse causal associations between gut microbiota and T2DM. Additionally, we selected the European GWAS data from the European Bioinformatics Institute (EBI) as a validation set for external validation of the MR analysis. In the third part, we aimed to clarify which gut microbiota contribute to the degree of causal association between group disorders and T2DM through multivariate MR analysis and Bayesian model averaging (MR-BMA).

Results

1. According to the meta-analysis results, the glycated hemoglobin concentration in the gut probiotic intervention group was significantly lower than in the control group. Following treatment, fasting blood glucose levels in the intervention group were significantly lower than those in the control group. 2. The results of two samples MR analysis revealed that there were causal relationships between six gut microbiota and T2DM. Genus Haemophilus and order Pasteurellaceae were negatively correlated with T2DM. Genus Actinomycetes, class Melanobacteria and genus Lactobacillus were positively correlated. Reverse MR analysis demonstrated that T2DM and gut microbiota did not have any reverse causal relationship. The external validation data set showed a causal relationship between gut microbiota and T2DM. 3. Multivariate MR analysis and MR-BMA results showed that the independent genus Haemophilus collection had the largest PP.

Conclusion

Our research results suggest that gut microbiota is closely related to T2DM pathogenesis. The results of further MR research and an analysis of the prediction model indicate that a variety of gut microbiota disorders, including genus Haemophilus, are causally related to the development of T2DM. The findings of this study may provide some insight into the diagnosis and treatment of T2DM.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO
Cultural adaptation of a self-review tool for health promoting universities in Bulgaria
Authors: Boncheva Petya , Dokova Klara
Published: June 2024

Introduction

The Health Promoting University initiative is unknown in Bulgaria, and the health promotion potential of Bulgarian universities has not been studied. In order to examine it, a suitable instrument is needed. The UK Healthy Universities Network provides an accessible Self-Review-Tool (SRT). Aim: To present the process of cultural adaptation of the SRT in Bulgarian language.

Methods

The standardized WHO methodology for cultural adaptation of instruments was followed in four stages: (1) Two language translations of the instrument into Bulgarian were made; (2) An expert Delphi discussion reached a consensus on specific health promoting (HP) terms, followed by a backward translation; (3) Pilot testing of the tool among university community representatives was conducted through a survey among a small sample, with independent responses to the SRT questionnaire followed by cognitive interviews; (4) Final revision of the instrument.

Results

Ten public health experts reached a consensus on the name of the initiative and various HP terms. Ten other respondents pre-tested the tool. Difficulties in responding the SRT concerned the meaning of some HP terms, complex words, the system of answers, limited applicability of some statements. Changes were made to 61 of the total 68 elements in the SRT.

Conclusion

All stages of the cultural adaptation were important for the final result. The adapted Bulgarian version of the SRT would be useful to Bulgarian universities that want to make a clear commitment to improving the health of their university community and the wider society.
A study on the monitoring of heatwaves and bivariate frequency analysis based on mortality risk assessment in Wuhan, China
Authors: Chen Si , Zhao Junrui , Dou Haonan , Yang Zhaoqian , Li Fei , Byun Jihye , Kim Seong Wook
Published: June 2024

The increasingly frequent occurrence of urban heatwaves has become a significant threat to human health. To quantitatively analyze changes in heatwave characteristics and to investigate the return periods of future heatwaves in Wuhan City, China, this study extracted 9 heatwave definitions and divided them into 3 mortality risk levels to identify and analyze historical observations and future projections of heatwaves. The copula functions were employed to derive the joint distribution of heatwave severity and duration and to analyze the co-occurrence return periods. The results demonstrate the following. (1) As the concentration of greenhouse gas emissions increases, the severity of heatwaves intensifies, and the occurrence of heatwaves increases significantly; moreover, a longer duration of heatwaves correlated with higher risk levels in each emission scenario. (2) Increasing concentrations of greenhouse gas emissions result in significantly shorter heatwave co-occurrence return periods at each level of risk. (3) In the 3 risk levels under each emission scenario, the co-occurrence return periods for heatwaves become longer as heatwave severity intensifies and duration increases. Under the influence of climate change, regional-specific early warning systems for heatwaves are necessary and crucial for policymakers to reduce heat-related mortality risks in the population, especially among vulnerable groups.
Applications and advances in molecular diagnostics: revolutionizing non-tuberculous mycobacteria species and subspecies identification
Authors: Zhang Haiyang , Tang Maoting , Li Deyuan , Xu Min , Ao Yusen , Lin Liangkang
Published: June 2024

Non-tuberculous mycobacteria (NTM) infections pose a significant public health challenge worldwide, affecting individuals across a wide spectrum of immune statuses. Recent epidemiological studies indicate rising incidence rates in both immunocompromised and immunocompetent populations, underscoring the need for enhanced diagnostic and therapeutic approaches. NTM infections often present with symptoms similar to those of tuberculosis, yet with less specificity, increasing the risk of misdiagnosis and potentially adverse outcomes for patients. Consequently, rapid and accurate identification of the pathogen is crucial for precise diagnosis and treatment. Traditional detection methods, notably microbiological culture, are hampered by lengthy incubation periods and a limited capacity to differentiate closely related NTM subtypes, thereby delaying diagnosis and the initiation of targeted therapies. Emerging diagnostic technologies offer new possibilities for the swift detection and accurate identification of NTM infections, playing a critical role in early diagnosis and providing more accurate and comprehensive information. This review delineates the current molecular methodologies for NTM species and subspecies identification. We critically assess the limitations and challenges inherent in these technologies for diagnosing NTM and explore potential future directions for their advancement. It aims to provide valuable insights into advancing the application of molecular diagnostic techniques in NTM infection identification.
Global cloud optical depth daily variability based on DSCOVR/ EPIC observations
Authors: Delgado-Bonal A. , Marshak A. , Yang Y. , Oreopoulos L.
Published: June 2024

When investigating the potential effects of cloud changes on climate, the interday and intraday variabilities should be distinguished. Historically, studies have focused on the long-term cloud changes, and the intraday cycles of cloud properties have been mostly ignored partly owing to the limited availability of global datasets to study higher frequency variabilities. In this regard, DSCOVR’s vantage point at the Lagrange L1 point overcomes the temporal limitations of polar orbiters as well as the limited spatial views of geostationary satellites, allowing characterization of the daytime variability of cloud properties using a single sensor. In previous analyses, we used DSCOVR’s EPIC instrument to characterize the diurnal cycles of cloud height and cloud fraction; here, we expand on previous studies to additionally investigate the variability of cloud optical thickness. We observe a recurring diurnal pattern of cloud optical thicknesses for different latitudinal zones that reaches a maximum around noon regardless of the underlying surface. Once we separate the clouds based on their optical thickness into optically thin (0–3), intermediate (3–10), and thick (10–25), we find that these cloud classes follow different optical thickness diurnal cycles on the global scale. We further explore these differences by combining the evolution of cloud fraction and optical thickness of each group to obtain the diurnal evolution of cloud-fraction-weighted optical depths.
Adoption and desirable characteristics of Information and Communication Technologies for urban small-scale food producers in South Africa
Authors: Alfonsi Robert Massimo , Naidoo Merle , Gasparatos Alexandros
Published: June 2024

Small-scale food producers can benefit significantly from the adoption and effective utilization of Information and Communication Technologies (ICTs). For example, ICTs can help improve food production and access to markets, which is particularly valuable in many Sub-Saharan African countries that both urbanize rapidly but whose food systems still rely significantly on small-scale food producers. This study examines the adoption patterns and desirable characteristics of ICTs, as well as the factors influencing them, among small-scale food producers engaged in urban agriculture in South Africa. We administered 85 in-person surveys through referrals from local producers’ network in disadvantaged areas of Cape Town (n = 21; Gugulethu, Philippi, Khayelitsha) and Johannesburg (n = 64; Central Business District, Soweto, Orange Farm). A substantial proportion of the respondents articulated the need for food-related mobile applications with functions that facilitate price comparisons, and the sharing of best practices and health advice. User-friendliness, low internet data use, and affordability were perceived as the most important characteristics for such food-related mobile applications. Redundancy analysis (RDA) reveals that the socioeconomic and demographic characteristics of respondents significantly influence the desired functionalities of food apps and their preferred activities among the respondents. Producers that are married and have more children, have higher income and education, and own larger land holdings, show very distinct patterns in terms of desirable functions and uses for food apps. Our research underscores the need for comprehensive approaches to the development and promotion of food-related ICTs when targeting small-scale food producers. The barriers and needs identified here can help ICT developers, development agencies and policy-makers design fit-for-purpose interventions and policies to facilitate ICT adoption among urban small-scale food producers in rapidly urbanizing areas.
Identification of parameters for electronic distance examinations
Authors: Richter Robin , Tipold Andrea , Schaper Elisabeth
Published: June 2024

Introduction

This study investigates the log data and response behavior from invigilated in-person electronic timed exams at the University of Veterinary Medicine Hannover, Foundation, Germany. The primary focus is on understanding how various factors influence the time needed per exam item, including item format, item difficulty, item discrimination and character count. The aim was to use these results to derive recommendations for designing timed online distance examinations, an examination format that has become increasingly important in recent years.

Methods

Data from 216,625 log entries of five electronic exams, taken by a total of 1,241 veterinary medicine students in 2021 and 2022, were analyzed. Various statistical methods were employed to assess the correlations between the recorded parameters.

Results

The analysis revealed that different item formats require varying amounts of time. For instance, image-based question formats and Kprim necessitated more than 60 s per item, whereas one-best-answer multiple-choice questions (MCQs) and individual Key Feature items were effectively completed in less than 60 s. Furthermore, there was a positive correlation between character count and response time, suggesting that longer items require more time. A negative correlation could be verified for the parameters “difficulty” and “discrimination index” towards response time, indicating that more challenging items and those that are less able to differentiate between high- and low-performing students take longer to answer.

Conclusion

The findings highlight the need for careful consideration of the ratio of item formats when defining time limits for exams. Regarding exam design, the literature mentions that time pressure is a critical factor, since it can negatively impact students’ exam performance and some students, such as those with disabilities, are particularly disadvantaged. Therefore, this study emphasizes finding the right time limits to provide sufficient time for answering questions and reducing time pressure. In the context of unsupervised online exams, the findings of this study support previous recommendations that implementation of a stringent time limit might be a useful strategy to reduce cheating.
The Design and Application of a Vectored Thruster for a Negative Lift-Shaped AUV
Authors: Zhu Hong , Lin Lunyang , Yu Chunliang , Chen Yuxiang , Xiong Hong , Xing Yiyang , Zheng Guodong
Published: June 2024

Autonomous underwater vehicles (AUVs), as primary platforms, have significantly contributed to underwater surveys in scientific and military fields. Enhancing the maneuverability of autonomous underwater vehicles is crucial to their development. This study presents a novel vectored thruster and an optimized blade design approach to meet the design requirements of a specially shaped AUV. Determining the ideal blade characteristics involves selecting a maximum diameter of 0.18 m and configuring the number of blades to be four. Furthermore, the blades of the AUV were set to rotate at a speed of 1400 revolutions per minute (RPM). The kinematics of the thrust-vectoring mechanism was theoretically analyzed. A propulsive force test of the vectored thruster with ductless and ducted propellers was performed to evaluate its performance. A ductless propeller without an annular wing had a higher propulsive efficiency with a maximum thrust of 115 N. Open-loop control was applied to an AUV in a water tank, exhibiting a maximum velocity of 0.98 m/s and a pitch angle of 53°. The maximum rate of heading angle was 14.26°/s. The test results demonstrate that the specially designed thrust-vectoring mechanism notably enhances the effectiveness of AUVs at low forward speeds. In addition, tests conducted in offshore waters for depth and heading control validated the vectored thruster’s capability to fulfill the AUV’s motion control requirements.
Environmental Impact of Choline Dihydrogenphosphate ([Chol][DHP]) on Seed Germination and Soil Microbial Activity
Authors: Cruz Óscar , Reyes Otilia , Trasar-Cepeda Carmen , Sixto Teresa , Parajó Juan José , Salgado Josefa
Published: June 2024

The applicability of ionic liquids has grown exponentially over the last few decades. This growth is due to the easy modification of these compounds formed by ions, through the proper choice of both moieties, and the possibility of introducing functional groups into their cations and anions. However, studies of their toxicity and effects on the environment remain scarce. This study analyses firstly the response to adding different concentrations of choline dihydrogen phosphate to the germination of seeds of eight plant species. It also examines the microbial population and the respiration of two soils with contrasting organic matter contents. Seeds were incubated in a Petri dish in a Phytotron with a photoperiod of 16 h under light at 24 °C and 8 h in darkness at 16 °C. The activity of microbial populations of untreated and treated soils was analysed by isothermal microcalorimetry at 25 °C. Basal soil respiration kinetics were measured at optimal moisture (80% of field water retention capacity) and temperature (25 °C) over 10 days. The results indicate that this compound has diverse effects on the different endpoints. Nevertheless, this compound can be classified as non-toxic considering its effects on seeds and on soil, at least in the medium- to long-term.
Calibration of a Hybrid Machine Tool from the Point of View of Positioning Accuracy
Authors: Tabakovic Slobodan , Zeljkovic Milan , Zivanovic Sasa , Budimir Alexander , Dimic Zoran , Kosarac Aleksandar
Published: June 2024

The development of machine tools in the last twenty years includes, among other things, the application of mechanisms with a non-linear kinematic structure as the mechanical basis of machines. This results in significant improvements in kinematic characteristics and problems related to non-linear dependencies of the accuracy of the drive elements and the realization of movement in the machine’s external coordinates. The paper presents an approach to machine tool calibration based on the original O-X glide mechanism based on the ISO 230-4 standard with the mono- and bi-directional compensation of systematic errors and adaptation to the specifics of the mechanism’s kinematics. A machine tool prototype was designed and built for the research presented in the paper. The obtained results indicate the possibility of applying the existing recommendations and standards for testing the accuracy of machine tools with the need to correct the methodology by using linear and non-linear kinematic structures in machine tools.
Parameter Calibration of Discrete Element Model of Wine Lees Particles
Authors: Zhang Xiaoyuan , Wang Rui , Wang Baoan , Chen Jie , Wang Xiaoguo
Published: June 2024

In order to investigate the contact characteristics of the mechanical parts of the brewing robot with wine lees particles, it is essential to calibrate the parameters of the discrete elemental model of wine lees particles. This paper proposes a method based on tests of the angle of repose. The simulation test is conducted to establish a regression model and combined with physical tests to find optimization. The contact model used in simulation modeling is Hertz-Mindlin with Johnson-Kendall-Roberts. Not all discrete element model parameters of wine lees particles have a significant impact on the angle of repose, so screening through Plackett-Burman Design is performed. The results indicate that the restitution coefficient between wine lees particles and restitution coefficient between wine lees particle and steel plate have a significant impact on angle of repose. Additionally, another parameter that is difficult to obtain, namely surface energy (JKR), also plays a crucial role. The optimal value interval for these three parameters is determined by the steepest ascent test, and a linear regression model for angle of repose is built through Box-Behnken Design. The optimal values obtained are as follows: restitution coefficient between wine lees particles—0.603; restitution coefficient between wine lees particle and steel plate—0.595; JKR—0.083. Finally, in order to verify the accuracy of calibrated parameters, simulation verification tests are carried out which show that there is only a relative error rate at 0.18% between simulated angle of repose and actual angle of repose, indicating that accurate calibration parameters were achieved. This study can provide reference for selecting discrete element model parameters for wine lees particles in future research endeavors.
Validity and Reliability of New Three-Dimensional Reference Systems for Soft Tissue Analysis Using Non-Ionizing Three-Dimensional Imaging
Authors: Rongo Roberto , D’Antò Vincenzo , Michelotti Ambrosina , Cornelis Marie A. , Cattaneo Paolo M.
Published: June 2024

Background: The aim of this study was to evaluate the accuracy and the repeatability of two reference systems for three-dimensional facial scans (FSs) compared with a reference system based on cone-beam computed tomography (CBCT). Subjects and methods: A total of sixty subjects, thirty growing participants (8–17 years old) and thirty non-growing participants (older than 21 years old), with FSs and full-field-of-view CBCT were included. Two different reference systems on the same FS were constructed. To assess validity, the two reference systems based on FSs were compared with the reference systems built using the CBCT scans. After two weeks, all of the FSs were reassessed to evaluate intra-operator repeatability. Reliability and repeatability were evaluated by means of parametric and non-parametric tests, intra-class correlation, the Dahlberg formula, and Bland–Altman plots (p < 0.05). Results: Both reference systems presented good reliability and showed a small difference with respect to the CBCT-based sagittal plane (Sagittal FS1 = 1.90 ± 0.98°; Sagittal FS2 = 1.80 ± 1.13°; p = 0.232). Between them, the two reference systems showed a small difference in the position of the sagittal plane (Sagittal FS1^Sagittal FS2 = 1.39 ± 1.13°). Conclusions: Both reference systems assessed in this study showed good intra-operator repeatability and their use may be suggested as reliable reference systems for FSs.
Methodology for the Detection of Contamination and Gradual Outer Race Faults in Bearings by Fusion of Statistical Vibration–Current Features and SVM Classifier
Authors: Díaz-Saldaña Geovanni , Cureño-Osornio Jonathan , Zamudio-Ramírez Israel , Osornio-Ríos Roque A. , Dunai Larisa , Sava Lilia , Antonino-Daviu Jose A.
Published: June 2024

Bearings are one of the main components of induction motors, machines widely employed in today’s industries, making their monitoring a primordial task; however, most systems focus on measuring one physical magnitude to detect one kind of fault at a time. This research tackles the combination of two common faults, grease contamination and outer race damage, as lubricant contamination significantly impacts the life of the bearing and the emergence of other defects; as a contribution, this paper proposes a methodology for the diagnosis of this combination of faults based on a proprietary data acquisition system measuring vibration and current signals, from which time domain statistical and fractal features are computed and then fused using LDA for dimensionality reduction, ending with an SVM model for classification, achieving 97.1% accuracy, correctly diagnosing the combination of the contamination with different severities of the outer race damage, improving the classification results achieved when using vibration and current signals individually by 7.8% and 27.2%, respectively.
Green Manufacturing of UHPFRC Made with Waste Derived from Scrap Tires and Oil Refineries
Authors: Abdolpour Hassan , Muthu Murugan , Niewiadomski Paweł , Sadowski Łukasz , Hojdys Łukasz , Krajewski Piotr , Kwiecień Arkadiusz
Published: June 2024

Ultrahigh-performance fiber-reinforced cement-based composite (UHPFRC) made with waste derived from scrap tires and oil refineries was tested in this study. The UHPFRC sample exhibited a maximum compressive strength of about 189 MPa at the end of 28 days. Steel fibers were recovered from scrap tires and were added up to 3% by volume in the UHPFRC samples. Such additions reduced cement flow by 11% but improved compressive strength by 21%. The equilibrium catalyst particles (ECAT) disposed of by oil refineries were used in amounts of up to 15% by weight as a replacement for cement in such UHPFRC samples. These aluminosilicate materials are spherical in shape and have a porous microstructure, which was found to reduce the cement flow by absorbing more free water onto their surfaces. They also reduced the heat and strength developments at early stages. However, the total cost of the final cement-based mixture and associated CO2 emissions were reduced by up to 7% and 15% due to the inclusion of the ECAT particles. These findings help to optimize the ECAT and recovered steel fibers in the UHPFRC mix design, and such waste valorization strategies can help achieve the goal of becoming carbon neutral.
The Role of Aging in Intracerebral Hemorrhage
Authors: Huang Baisong , Chen Anqi , Sun Yuanyuan , He Quanwei
Published: June 2024

Intracerebral hemorrhage (ICH) is the cerebrovascular disease with the highest disability and mortality rates, causing severe damage to the health of patients and imposing a significant socioeconomic burden. Aging stands as a foremost risk factor for ICH, with a significant escalation in ICH incidence within the elderly demographic, highlighting a close association between ICH and aging. In recent years, with the acceleration of the “aging society” trend, exploring the intricate relationship between aging and ICH has become increasingly urgent and worthy of in-depth attention. We have summarized the characteristics of ICH in the elderly, reviewing how aging influences the onset and development of ICH by examining its etiology and the mechanisms of damage via ICH. Additionally, we explored the potential impacts of ICH on accelerated aging, including its effects on cognitive abilities, quality of life, and lifespan. This review aims to reveal the connection between aging and ICH, providing new ideas and insights for future ICH research.
Transcranial Direct Current Stimulation to Ameliorate Post-Stroke Cognitive Impairment
Authors: Sloane Kelly L. , Hamilton Roy H.
Published: June 2024

Post-stroke cognitive impairment is a common and disabling condition with few effective therapeutic options. After stroke, neural reorganization and other neuroplastic processes occur in response to ischemic injury, which can result in clinical improvement through spontaneous recovery. Neuromodulation through transcranial direct current stimulation (tDCS) is a promising intervention to augment underlying neuroplasticity in order to improve cognitive function. This form of neuromodulation leverages mechanisms of neuroplasticity post-stroke to optimize neural reorganization and improve function. In this review, we summarize the current state of cognitive neurorehabilitation post-stroke, the practical features of tDCS, its uses in stroke-related cognitive impairment across cognitive domains, and special considerations for the use of tDCS in the post-stroke patient population.
Accelerated Bridge Construction Case: A Novel Low-Carbon and Assembled Composite Bridge Scheme
Authors: Kang Ling , Xu Jinhua , Mu Tingmin , Wang Huan , Zhao Ping
Published: June 2024

Modern bridge construction towards a higher degree of low carbonization and assembly has been the general trend, while developing and broadening the low-carbon and assembled-oriented Accelerated Bridge Construction (ABC) technology can better realize the trade-offs between construction quality, efficiency, cost and sustainability. In the current mainstream ABC technologies such as precast-assembled concrete bridge and assembled steel bridge schemes, it is difficult to achieve an excellent balance between the above multicriterion trade-offs. To this end, this paper proposes a novel low-carbon and assembled composite bridge scheme as an innovative case of ABC technology based on a 26.7 km-length urban viaduct project in China with urgent environmental protection and assembly demands. Construction sustainability, the comprehensive economy and low-carbon performance are well balanced by the collaborative application of new steel–concrete composite structures, the rapid assembly interface design and low-carbon material technologies. The proposed scheme has been applied to a completed real-scale bridge, and the whole construction process only experienced 105 days of effective time, accompanied with slight environmental interference and construction noise and a small amount of labor and equipment input. In addition, the safety of the bridge, the rationality of the design concept and the calculation method have been verified by the static and dynamic loading tests of the real-scale bridge.
A Linear Optimization for Slope Leveling of Ground-Mounted Centralized Photovoltaic Sites
Authors: Tao Yanli , Zheng Nan , Cheng Yuanzhe , Zhu Jianfeng , Zhong Weibin , Sun Yasong , Zhao Jianyong , Dong Baoshun , Wang Yongming , Ren Jinming
Published: June 2024

Slope leveling is essential for the successful implementation of ground-mounted centralized photovoltaic (PV) plants, but currently, there is a lack of optimization methods available. To address this issue, a linear programming approach has been proposed to optimize PV slope leveling. This method involves dividing the field into blocks and grids and using hyperbolic paraboloids to simulate the design surface. By programming in MATLAB, the globally optimal solution for PV slope leveling can be calculated. Engineering case studies have demonstrated that this optimization method can achieve significant cut-and-fill volume savings ranging from 58% to 78%, when compared to the traditional segmented plane method. Additionally, the effectiveness of the optimization method improves with larger site areas and more complex terrains. A parameter analysis considering slope ratio, grid size, and block size reveals that grid size has a minimal impact on cut-and-fill volume, while slope ratio and block size have a significant influence. For typical PV projects, the recommended ranges of slope ratio, grid size, and block size are 3–7%, 5–20 m, and 30–50 m, respectively, for slope leveling design. In summary, the proposed linear optimization method provides an optimal slope leveling scheme for ground-mounted centralized PV plants, with convenient operation and fast computation.
Resistance to Targeted Inhibitors of the PI3K/AKT/mTOR Pathway in Advanced Oestrogen-Receptor-Positive Breast Cancer
Authors: Browne Iseult M. , Okines Alicia F. C.
Published: June 2024

The PI3K/AKT/mTOR signalling pathway is one of the most frequently activated pathways in breast cancer and also plays a central role in the regulation of several physiologic functions. There are major efforts ongoing to exploit precision medicine by developing inhibitors that target the three kinases (PI3K, AKT, and mTOR). Although multiple compounds have been developed, at present, there are just three inhibitors approved to target this pathway in patients with advanced ER-positive, HER2-negative breast cancer: everolimus (mTOR inhibitor), alpelisib (PIK3CA inhibitor), and capivasertib (AKT inhibitor). Like most targeted cancer drugs, resistance poses a major problem in the clinical setting and is a factor that has frequently limited the overall efficacy of these agents. Drug resistance can be categorised into intrinsic or acquired resistance depending on the timeframe it has developed within. Whereas intrinsic resistance exists prior to a specific treatment, acquired resistance is induced by a therapy. The majority of patients with ER-positive, HER2-negative advanced breast cancer will likely be offered an inhibitor of the PI3K/AKT/mTOR pathway at some point in their cancer journey, with the options available depending on the approval criteria in place and the cancer’s mutation status. Within this large cohort of patients, it is likely that most will develop resistance at some point, which makes this an area of interest and an unmet need at present. Herein, we review the common mechanisms of resistance to agents that target the PI3K/AKT/mTOR signalling pathway, elaborate on current management approaches, and discuss ongoing clinical trials attempting to mitigate this significant issue. We highlight the need for additional studies into AKT1 inhibitor resistance in particular.
The Challenging Approach to Multiple Myeloma: From Disease Diagnosis and Monitoring to Complications Management
Authors: Morè Sonia , Corvatta Laura , Manieri Valentina Maria , Morsia Erika , Offidani Massimo
Published: June 2024

The outcome of multiple myeloma (MM) has significantly improved in the last few decades due to several factors such as new biological discoveries allowing to better stratify disease risk, development of more effective therapies and better management of side effects related to them. However, handling all these aspects requires an interdisciplinary approach involving multiple knowledge and collaboration of different specialists. The hematologist, faced with a patient with MM, must not only choose a treatment according to patient and disease characteristics but must also know when therapy needs to be started and how to monitor it during and after treatment. Moreover, he must deal not only with organ issues related to MM such as bone disease, renal failure or neurological disease but also with adverse events, often very serious, related to novel therapies, particularly new generation immunotherapies such as CAR T cell therapy and bispecific antibodies. In this review, we provide an overview on the newer MM diagnostic and monitoring strategies and on the main side effects of MM therapies, focusing on adverse events occurring during treatment with CAR T cells and bispecific antibodies.
Correction: Ishikawa et al. Systematic Review of Beta-Lactam vs. Beta-Lactam plus Aminoglycoside Combination Therapy in Neutropenic Cancer Patients. Cancers 2024, 16, 1934
Authors: Ishikawa Kazuhiro , Nakamura Tomoaki , Kawai Fujimi , Ota Erika , Mori Nobuyoshi
Published: June 2024

There was an error in the original publication [...]
Prediction of Efficacy for Atezolizumab/Bevacizumab in Unresectable Hepatocellular Carcinoma with Hepatobiliary-Phase Gadolinium Ethoxybenzyl-Diethylenetriaminepentaacetic Acid MRI
Authors: Kunichika Hideki , Minamiguchi Kiyoyuki , Tachiiri Tetsuya , Shimizu Kozo , Taiji Ryosuke , Yamada Aya , Nakano Ryota , Irizato Mariko , Yamauchi Satoshi , Marugami Aki , Marugami Nagaaki , Kishida Hayato , Nakagawa Hiroyuki , Takewa Megumi , Kageyama Ken , Yamamoto Akira , Ueshima Eisuke , Sofue Keitaro , Kita Ryuichi , Kurakami Hiroyuki , Tanaka Toshihiro
Published: June 2024

Background: This study aimed to examine whether the coefficient of variation (CV) in the hepatobiliary-phase (HBP) of Gd-EOB-DTPA-MRI could be an independent predictive factor for tumor progression. Methods: Patients who underwent Gd-EOB-DTPA-MRI before Atezolizumab/bevacizumab therapy at six affiliated institutions between 2018 and 2022 were included. CV for each patient was calculated as the mean value for up to five tumors larger than 10 mm, and CV of the whole tumor was calculated using LIFEx software. The tumor response was evaluated within 6–10 weeks. The primary endpoint was to investigate the predictive factors, including CV, related to tumor progression using logistic regression analysis. The secondary endpoints were tumor response rate and progression-free survival (PFS) based on CV. Results: Of the 46 enrolled patients, 13 (28.3%) underwent early progressive disease. Multivariate analysis revealed that a high CV (≥0.22) was an independent predictive factor for tumor progression (p = 0.043). Patients with a high CV had significantly frequent PD than those with a low CV (43.5 vs. 13.0%, p = 0.047). Patients with a high CV tended to have shorter PFS than those with a low CV (3.5 vs. 6.7 months, p = 0.071). Conclusion: Quantitative analysis using CV in the HBP of Gd-EOB-DTPA-MRI may be useful for predicting tumor progression for atezolizumab/bevacizumab therapy.
Baseline Cell-Free DNA Can Predict Malignancy of Nodules Observed in the ITALUNG Screening Trial
Authors: Bisanzi Simonetta , Puliti Donella , Picozzi Giulia , Romei Chiara , Pistelli Francesco , Deliperi Annalisa , Carreras Giulia , Masala Giovanna , Gorini Giuseppe , Zappa Marco , Sani Cristina , Carrozzi Laura , Paci Eugenio , Kaaks Rudolf , Carozzi Francesca Maria , Mascalchi Mario
Published: June 2024

The role of total plasma cell-free DNA (cfDNA) in lung cancer (LC) screening with low-dose computed tomography (LDCT) is uncertain. We hypothesized that cfDNA could support differentiation between malignant and benign nodules observed in LDCT. The baseline cfDNA was measured in 137 subjects of the ITALUNG trial, including 29 subjects with screen-detected LC (17 prevalent and 12 incident) and 108 subjects with benign nodules. The predictive capability of baseline cfDNA to differentiate malignant and benign nodules was compared to that of Lung-RADS classification and Brock score at initial LDCT (iLDCT). Subjects with prevalent LC showed both well-discriminating radiological characteristics of the malignant nodule (16 of 17 were classified as Lung-RADS 4) and markedly increased cfDNA (mean 18.8 ng/mL). The mean diameters and Brock scores of malignant nodules at iLDCT in subjects who were diagnosed with incident LC were not different from those of benign nodules. However, 75% (9/12) of subjects with incident LC showed a baseline cfDNA ≥ 3.15 ng/mL, compared to 34% (37/108) of subjects with benign nodules (p = 0.006). Moreover, baseline cfDNA was correlated (p = 0.001) with tumor growth, measured with volume doubling time. In conclusion, increased baseline cfDNA may help to differentiate subjects with malignant and benign nodules at LDCT.
Synthesis of CBO (Co3O4-Bi2O3) Heterogeneous Photocatalyst for Degradation of Fipronil and Acetochlor Pesticides in Aqueous Medium
Authors: Saeed Muhammad , Panchal Sandeep , Bajaber Majed A. , Alalwiat Ahlam A. , Ahmed Ahmed Ezzat , Razzaq Ujala , Rab Nawaz Hafiza Zahra , Hussain Farhat
Published: June 2024

The excessive use of pesticides has led to the harmful contamination of water reservoirs. Visible-light-driven photocatalysis is one of the suitable methods for the removal of pesticides from water. Herein, the development of CBO (Co3O4-Bi2O3) as a heterogeneous catalyst for the visible light-assisted degradation of Fipronil and Acetochlor pesticides is reported. After synthesis via coprecipitation using cobalt (II) nitrate hexahydrate (Co(NO3)2·6H2O), bismuth (III) nitrate pentahydrate (Bi(NO3)3·5H2O) and sodium hydroxide (NaOH) as precursor materials, the prepared CBO was characterized using advanced techniques including XRD, EDS, TEM, SEM, FTIR, and surface area and pore size analysis. Then, it was employed as a photocatalyst for the degradation of Fipronil and Acetochlor pesticides under visible light irradiation. The complete removal of Fipronil and Acetochlor pesticides was observed over CBO photocatalyst using 50 mL (100 mg/L) of each pesticide separately within 120 min of reaction. The reaction kinetics was investigated using a non-linear method of analysis using the Solver add-in. The prepared CBO exhibited a 2.8-fold and 2-fold catalytic performance in the photodegradation of selected pesticides than Co3O4 and Bi2O3 did, respectively.