bluuebunny/crossref_metadata_2025 huggingface dataset:
Особенности клинического течения перфоративных язв желудка и двенадцатиперстной кишки у детей
Authors: Zaporozhchenko A.G. , Gladky A.P. , Dovbysh O.V. , Spakhi O.V.
Published: January 2022

Анализу подвергнуто 52 больных в возрасте от 14 до 17 лет с перфоративной язвой желудка и двенадцатиперстной кишки, оперированных лапароскопическим и открытым способами. Установлено, что перфоративные язвы желудка и двенадцатиперстной кишки у детей возникают внезапно, характеризуются отсутствием «язвенного анамнеза» и манифестной клиникой острого перитонита у 77 % детей. Максимальная эффективность диагностики перфоративных язв желудка и двенадцатиперстной кишки достигается при использовании комплексной диагностической программы, включающей поэтапное проведение диагностических мероприятий с учетом их разрешающей способности в каждом конкретном случае.
Респираторная инфекция, вызванная Chlamydophila pneumonia, у детей. Подходы к диагностике и лечению
Authors: Yulish Ye.I. , Gadetskaya S.G. , Vakulenko S.I. , Kolesnikova V.S.
Published: January 2022

В работе представлены данные о частоте респираторного хламидиоза у детей с острыми и хроническими заболеваниями органов дыхания. Описаны особенности течения этих заболеваний на фоне респираторного хламидиоза. Предложены методы диагностики и лечения различных форм хламидийной инфекции, вызванной Chlamydophila pneumonia, у детей с патологией респираторного тракта.
Клініко-ехокардіографічна діагностика походження пролапсу мітрального клапана в дітей
Authors: Kondratiev V.A. , Abaturova N.I. , Porokhnia N.G. , Kunak O.V.
Published: January 2022

З метою визначення гемодинамічних і морфометричних особливостей пролапсу мітрального клапана запального й незапального генезу за допомогою методу допплерехокардіографії обстежено 34 дитини віком від 5 до 17 років. У дітей із пролапсом мітрального клапана запального генезу вірогідно частіше виявлялося потовщення стінок міокарда й збільшення маси міокарда, що свідчило про гіпертрофію лівого шлуночка; частіше виявлявся пролапс ІІ–ІІІ ступеня; вірогідно частіше виявлялась мітральна регургітація ІІІ ступеня, що призводила до розвитку хронічної серцевої недостатності. У 83,3–94,4 % випадків виявлялося значне й різке підвищення ультразвукової щільності папілярних м’язів лівого шлуночка, що не було характерним для пролапсу незапального генезу. В обох групах дітей із пролапсом мітрального клапана переважало підвищення ультразвукової щільності передньої стулки. Потовщення передньої стулки понад 3 мм вірогідно частіше спостерігалось у дітей із пролапсом мітрального клапана запального генезу.
Первичный гемофагоцитарный лимфогистиоцитоз у новорожденного ребенка
Authors: Kozhemiaka A.I. , Klymenko V.A. , Kandyba V.P. , Piontkovska O.V. , Khalturyna T.A. , Postnikov A.V. , Perkhun M.I. , Zorya O.A.
Published: January 2022

В статье представлены данные клинического наблюдения гемофагоцитарного лимфогистиоцитоза у новорожденного ребенка, осложненного спонтанным разрывом селезенки. Обсуждаются вопросы диагностики согласно рекомендациям Международного общества по изучению гистиоцитарных заболеваний (Histocyte Society, 2004).
BRIEF REVIEW ON THERMOPHILIC BACTERIA AND THEIR APPLICATIONS
Authors: MANE ROHIT SHANKAR , NADAF ASAMA
Published: January 2022

Enzymes from incredibly thermophilic microorganisms have been of innovative interest for quite a while in view of their capacity to catalyses responses of modern importance at raised temperatures. Most of the potential bioprospecting is at present identified with the investigation of the extremophiles and their likely use in modern cycles. As of late microbial enzymes discover applications in different businesses and comprise a significant gathering of modern enzymes. Present review article reveals basics of thermophilic bacteria and their applications with thermostability.
NUTRACEUTICAL POTENTIAL OF VERMICELLI PREPARED BY GLUTEN-FREE COMPOSITE FLOUR
Authors: AGARWAL SRISHTI , CHAUHAN EKTA SINGH
Published: January 2022

Objective: Nutritional, phytochemical and antioxidant properties of all ratios of gluten free composite flour-based Vermicelli was evaluated in this study. The blend of proso millet flour (PF), adzuki bean flour (AF) and basil seeds flour (BF) was used in composite flour.

Methods: The variations of three composite flours were prepared as, A being (PF: AF: BF=50:45:5), B being (PF: AF: BF=60:35:5) and C being (PF: AF: BF=70:25:5), respectively. The macronutrients like moisture, ash, fat, fiber, protein and carbohydrate were assessed in this study. Minerals such as calcium, iron, phosphorus and zinc were analyzed in micronutrients.

Results: The result of macronutrient and micronutrient of a ratio were moisture (5.2±0.1), ash (2.1±0.2), protein (13.0±0.0), fat (1.6±0.0), fiber (3.0±0.0) and carbohydrate (60.0±0.2g/100g) respectively. Calcium (150.0±0.3), iron (3.5±0.1), zinc (2.0±0.3) and phosphorus (250.6±0.6 mg/100g) were also there in gluten-free Pasta. The current study revealed that various macro and micronutrients were present in gluten-free Vermicelli. In the prepared products, flavonoids, saponins, tannin, glycocides, alkaloids and steroids are the few phytochemicals present. The study results also show that gluten-free Vermicelli has good antioxidant activity. In the A ratio, overall, all nutrients are found. It was found by the sensory evaluation Vermicelli on a 9 point hedonic scale that A ratio was more acceptable than the B and C ratio.

Conclusion: Therefore, it can be useful for celiac diseases as well as patients suffering from diseases like hypertension, anemia and diabetes.
Application of Morning Glory Flower (Ipomea purpurea) Extract for Colouring Plant Section Preparation
Authors: Wahyuni Sri , Zaenab Siti , Kurniasari Windi , Iriani Ayu , Hapsari Maharani Dewinta
Published: January 2022

Background: Preparing requires colouring to clarify or sharpen various tissue parts, especially cells. The use of synthetic dyes in preparations in the long term can less impact both living things and the environment. The study aims to obtain natural dyes from morning glory flowers at optimal temperatures and pH and find out the feasibility of preparations coloured using Morning Glory flower extract. Method: The extraction process uses a maceration method with different temperature variations of 400C, 500C, 600C, 700C, 800C and different pH i.e. 3, 4, 5, 6. The preparation process uses different dye concentration variations. The concentrations used are 50%, 60%, 70%, 80%, 90%, 100%. Data analysis techniques use descriptive and percentage analysis methods. Results: Morning glory flower extract (Ipomoea purpurea (L.) Roth) can colour dermal tissue, empulur, cortex and transport beams on the stems of cayenne pepper plants (Capsicum frutescens L.). Conclusion: Natural dyes of morning glory flowers can be used as a learning medium with a 74% eligibility rate for preparing with morning glory flower dyes.
Nipah Resistant Starch (Nypa fruticans): Modulation of Normal Microflora of Digestion, and Control of Diabetes
Authors: Aulia Vanya , Pachira Pellya , Olvi Monika , Simamora Cico Jhon Karunia
Published: January 2022

Background: Gut microbiota in diabetics, the number is in an unstable condition, and sufferers tend to need foods low in calories not to raise blood sugar levels drastically. Nipah grown in coastal areas has a fairly high starch content, potentially as a source of resistant starch that a beneficial colon microbiota can ferment. The purpose of writing this review is to expand knowledge and provide information to the wider community regarding the potential of Nipah, which can be used as a source of new resistant starch that can be used in diabetes and modulation of normal microflora of the body. Method: This review writing procedure is done by searching various literature electronically, namely accessing International and National article searches and books through databases such as Google Scholar, ScienceDirect, and others. The collected data is then processed using Mendeley and then synthetic with narrative methods to conclude (interpretation). Results: Results in the writing of this review, namely obtained Nipah fruit flour with a high enough starch content, which is 35.66%, which has the potential as a source of resistant starch. Conclusion: The writing of this review is that the high content of Nipah starch can be developed into a cheap, resistant starch innovation specifically for people with diabetes.
The Development of PBL Integrated Bioenvironmentalscience App (BES App) for Environmental Learning
Authors: Winda Purnama Sari  , Aprilliandari Dwi Indra
Published: January 2022

Background: Biology learning under the Covid-19 pandemic aimed to enhance educators' pedagogical competence by improving thinking abilities and producing results. One of the innovations intended to facilitate environmental learning is the BioEnviroScience App (BES App) for learning environmental science materials, specifically in the sub-environmental changes that occurred in the Province of the Bangka Belitung Islands. This media is integrated with Problem Based Learning (PBL) characteristics to guide the learning, allowing students to obtain learning experiences and make learning meaningful. Methods: This development design uses D&DR, which consists of six stages: 1) identifying the problem, 2) describing the objectives, 3) designing and developing the artifact, 4) testing the artifact, 5) evaluating testing results, and 6) communicating the testing findings. The feasibility test of the produced medium comprises a material, biological, and media specialists and is supported by peer review. A questionnaire was used to obtain data, which was examined quantitatively. Results: The material aspect of the feasibility test received 91.08% in the excellent category, the learning aspect of biology received 85.03% in the excellent category, and the media aspect received 89.08% in the excellent category. Conclusion: BES App deserves to be implemented on a large scale in several high schools in Pangkalpinang City.
Pelatihan Penulisan Penelitian Tindakan Kelas Berbasis Teknologi Open Journal System dan Penggunaan Software R pada MGMP Matematika SMP
Authors: Taqwa Muhammad , Razak Firdha , Mahmud Amrullah
Published: January 2022

Background: Mathematics Teachers who are members of MGMP (Teacher's Deliberation of Subjects) Mathematics at the Junior High School level of Pangkep Regency face problems in writing classroom action research (PTK), processing and analyzing data from PTK research results using software, as well as the publication of PTK scientific articles in the Open Journal System (OJS). The purpose to improve (1) the teacher's knowledge of the way of writing classroom action research (PTK); (2) the teacher's knowledge of software R statistical applications; (3) teacher knowledge of the Open Journal System (OJS). Method: Learning Model Technology, Pedagogy, and Content Knowledge (TPACK) consists of 4 steps: understanding (P), observation-instruction (O), instruction exercises (L), reflection (R). Training Partner is MGMP Mathematics junior high school pangkep which amounted to 12 people. Instruments of devotion in the form of: tests of classroom action research knowledge; test of software knowledge R; Open Journal System (OJS) knowledge test. Results: (1) increased teacher knowledge of how to write class actions; (2) increased teacher knowledge about processing classroom action research data with Software R; (3) Increased teacher knowledge about the publication of scientific articles of classroom action research in the Open Journal System (OJS). Conclusion: OJS Technology-Based PTK Training and The Use of Software R can overcome teacher difficulties in writing PTK, processing and analyzing PTK research data, as well as the publication of PTK scientific articles in the Open Journal System (OJS).
Literasi Aspek Pemasaran pada UKM “Nabil Collection”
Authors: Diah Madusari Benny , Ardianingsih Arum , Edi Wibowo Dwi
Published: January 2022

Background: “Nabil Collection” are SMEs affected by restrictions on activities outside the home.  SME “Nabil Collection” has been selling its shirt products conventionally so that when there is a policy of limiting activities outside the home, the sales of their products decrease. This literacy is carried out so that the SME “Nabil Collection” has the ability to do product packaging, the importance of trademarks and choose the right marketing media according to the product market target. Method: Literacy for SME owners “Nabil Collection” by providing modules on the marketing aspects of shirt products. Result: increased knowledge of “Nabil Collection” SME owners about product packaging, trademarks and online marketing media with social media. Conclusions: This literacy aspect of marketing increases the knowledge of “Nabil Collection” SME owners knowing more creative product packaging, realizing the importance of trademarks, more competitive shirt product prices and trying alternative social media-based marketing media to increase product sales during the time of restrictions on activities outside the home.
Pendampingan Perencanaan Pengembangan Desa Wisata Towale Dalam Peningkatan Ekonomi Desa Di Masa Pandemik
Authors: Sutomo Maskuri , Muslimin Muslimin , Mangun Nudiatulhuda , Rombe Elimawati , Taqwa Edy
Published: January 2022

Background: The impact of the Pandemic, which is very pronounced in the tourism sector, requires the government, actors and scholars to be able to adapt and plan tourism development in accordance with current conditions. The tourist village is the most possible alternative for tourism, considering that the mobilization of tourists is still local-oriented, the involvement of the community in this tour is very high. The government and village communities are required to be able to formulate strategic plans in developing village tourism, given the limited resources they have, the role of academics is needed to assist and facilitate the preparation of plans until they arrive at implementation. Method: This method of community service approach in the Towale Tourism Village uses a mentoring and facilitation approach in planning the development of the Towale Tourism Village. Result: The results of village planning assistance and facilitation focus on increasing tourist attraction and developing village tourism businesses as economic added value for the community. Conclusion: Potential tourist attractions in Towale Village are Karampuana Beach, Traditional Woven Fabric, Auliya Old Mosque, Bulava Pongeo and ontel bike community.
Glomerulonefritis C3 en un paciente consíndrome de Alport: un caso raro
Authors: Sánchez Solano María Alejandra , Guerrero Tinoco Gustavo Adolfo
Published: January 2022

El Síndrome de Alport es una entidad hereditaria que se produce principalmente por una mutación en los genes que codifican el colágeno tipo IV. Por otro lado, La glomerulonefritis C3 es una entidad rara que presenta un patrón de glomerulonefritis membranoproliferativa y su etiología se basa en un control anormal de la activación de la vía alternativa del complemento. A continuación, se describe un caso de un paciente de sexo masculino que cursa con un síndrome nefrótico corticorresistente en el que se documenta un patrón de glomerulonefritis membranoproliferativa en la biopsia renal con depósitos de C3 en la inmunofluorescencia, asociada a una deleción heterocigota en el gen CFHR1 en el estudio genético de las proteínas reguladoras del complemento. Además, en el panel genético realizado por corticorresistencia se encuentra una variante COL4A5 asociada al síndrome de Alport ligado al X. Estas entidades pueden presentarse con un curso clínico diverso, pero al estar asociadas pueden acelerar la progresión a enfermedad renal crónica, por lo que se hace necesario hacer un seguimiento clínico más estricto.
SEMANTIC GRAPH KNOWLEDGE REPRESENTATION FOR AL-QURAN VERSES BASED ON WORD DEPENDENCIES
Authors: Mohamad Khazani Muhammad Muhtadi , Mohamed Hassan , Tengku Sembok Tengku Mohd , Mohd Yusop Nurhafizah Moziyana , Wani Sharyar , Gulzar Yonis , Mohamed Halip Mohd Hazali , Marzukh Syahaneim , Yunos Zahri
Published: January 2022

Semantic approaches present an efficient, detailed and easily understandable representation of knowledge from documents. Al-Quran contains a vast amount of knowledge that needs appropriate knowledge extraction. A semantic based approach can help in designing an efficient and explainable knowledge representation model for Al-Quran. This research aims to propose a semantic-graph knowledge representation model for verses of Al-Quran based on word dependencies. These features are used in the proposed knowledge representation model allowing the semantic graph matching to improve Al-Quran search applications' accuracy. The proposed knowledge representation model is essentially a formalism for generating a semantic graph representation of Quranic verses, which can be applied for knowledge base construction for other applications such as information retrieval system. A set of rules called Semantic Dependency Triple Rules are defined to be mapped into the semantic graph representing the verse's logic. The rules translate word dependencies and other NLP metadata into a triple form that holds logical information. The proposed model has been tested with English translation of Al-Quran on a document retrieval prototype The basic system has been enhanced with anaphoric pronouns correction, which has shown improvement in retrieval performance. The results have been compared with a closely related system and evaluated on the accuracy of the document retrieval in Precision, Recall and F-score measurements. The proposed model has achieved 65%, 60% and 62.4% for the measurements, respectively. It has also improved the overall accuracy of previous system by 43.8%.
Development and validation of a dissolution test for empagliflozin in film-coated tablets
Authors: Manoel Joanna Wittckind , Primieri Gabriele Bordignon , Volpato Nadia Maria , Steppe Martin
Published: January 2022

The present study proposes a validated dissolution method for empagliflozin (EMPA) in film coated tablets. A gradual in vitro dissolution profile for this formulation was obtained using 900 mL of hydrochloric acid 0.01 M at 37 °C ± 0.5 °C as dissolution medium and USP apparatus 2 (paddle) at 50 rpm. The dissolved percentage of EMPA was quantified by ultraviolet spectrophotometric method to obtain cost technique and produce little residual solvents. Validation parameter for dissolution methodology such as the specificity, linearity, accuracy and precision were evaluated according to the international guidelines, giving results within the acceptable range. The method is linear in the range of 1 - 40 µg/mL, precise, with RSD value less than 2.62%, accurate (mean recovery 106.97%) and robust. Therefore, since no official method has been described, the proposed dissolution conditions represent a relevant contribution to evaluate the dissolution profile of coated tablet containing 25 mg of EMPA.
Lead evaluation in children's lipsticks through atomic absorption spectrometry
Authors: Fagundes Silvia Cristina , Rossato-Grando Luciana Grazziotin , Souza Camila Favretto , Fiorentin Oberdan , Mistura Clovia Marozin , Bertol Charise Dallazen
Published: January 2022

Lead is a metal with recognized toxicity and it is known that it may be a contaminant in lipsticks. In Brazil, the Health Regulatory Agency (ANVISA) determines that the maximum limit allowed for the presence of lead in lipsticks is 20 ppm. Children are more vulnerable to lead toxicity. The objective of this study was to evaluate the presence of lead in infant lipsticks. Nineteen samples from four different brands sold in Brazil were evaluated. After sample extraction, analyses were performed by graphite furnace atomic absorption spectrometry. Lead was not detected in any of the tested lipsticks. Considering the presence of lead in adult makeup, the present study reinforces the need to use products intended for children considering kids are more vulnerable to lead toxic effects.
Rapid stability-indicating UHPLC method for determination of lamivudine and tenofovir disoproxil fumarate in fixed-dose combination tablets
Authors: De Souza Danielle Evangelista Rabelo , Gomes Nicoly Kaliny Magela , Pianetti Gerson Antônio , Pereira Bruno Gonçalves , Fernandes Christian
Published: January 2022

Lamivudine (3TC) and tenofovir disoproxil fumarate (TDF) are antiretroviral drugs widely used for AIDS treatment. Since safety, efficacy and quality are essential for drug products, stability studies must be performed. Therefore, degradation studies must be carried out to evaluate the degradation products formed. The active pharmaceutical ingredients 3TC and TDF, as well as the tablets containing the combination of these drugs were subjected to a comprehensive forced degradation. 3TC, TDF and the degradation products were analyzed by a stability-indicating ultra-high performance liquid chromatography (UHPLC) method developed and validated. A C8 (100 x 2.0 mm, 2.2 μm) column and a mobile phase composed of 0.1 M ammonium acetate buffer pH 4.0, acetonitrile and methanol in gradient elution, at 0.5 mL/min, were used. The injection volume was 4 μL and detection was at 260 nm. The method was selective, precise, accurate and linear in the range 0.1-0.6 mg mL-1 for the two drugs. 3TC was degraded in acidic, alkaline and oxidative environment and in the presence of metal ions. Two degradation products were observed. TDF was degraded in the same conditions than those 3TC was labile. In addition, TDF was degraded in neutral condition. Again, two degradation products were formed. Chemical structures were proposed for the degradation products using UHPLC-QTOF/MS. The stability-indicating method developed showed to be useful in stability studies and in the quality control of fixed-dose combination tablets containing 3TC and TDF.
Ceftaroline fosamil: development a rapid HPLC method indicating stability and bioassay for determination in pharmaceutical formulation, stability and cytotoxicity studies
Authors: Mascarello Junior Idamir José , Sponchiado Rafaela Martins , Cordenonsi Leticia Malgarin , Oppe Tércio Oppe , Shapoval Elfrides Eva Scherman
Published: January 2022

The present study reports the development and validation of a microbiological assay. To assess this methodology, the method was developed and validated for the quantification of CEF by high performance liquid chromatography (HPLC). The validation of the microbial assay by diffusion method in 3x3 cylinder agar presented showed satisfactory results as to specificity, linearity in the range of 2.0 - 8.0 μg.mL-1, precision (109.42 %), accuracy (102.3 %), and robustness. The development and validation of the method by HPLC were evaluated according to specificity, linearity, precision, accuracy and robustness. A high performance liquid chromatography from Shimadzu with Agilent® C18 column, mobile phase (water with triethylamine 1.0 % pH 5.0: acetonitrile 87:13 v/v was used in the chromatographic method. The validated microbiological and chromatographic methods were compared statistically and there was no significant difference between them when compared by Student's t-test. In the preliminary stability study, it was found stable in acid hydrolysis (0.1M) and UVA light in the period evaluated, and unstable against thermal degradation (40 and 60 °C), oxidative with hydrogen peroxide, basic in NaOH (0.1 M and 0.01M) and UVC light. Samples exposed to UVC light and thermal degradation at 60°C showed degradation kinetics following zero order and second order, respectively. The cytotoxicity assay showed no difference between the normal condition and the sample submitted to forced degradation, suggesting that the possible degradation products formed did not change the result. The methods developed did not present a significant difference, therefore, they are interchangeable, and so can be used for routine quality control analysis.
NO BALANÇO DAS BRUXAS, DE FRANKLIN CASCAES: UM ESTUDO ACERCA DO MAL A PARTIR DE PRESSUPOSTOS DOS ESTUDOS DO IMAGINÁRIO E DA MEMÓRIA
Authors: Voltolini Ana Caroline , Moraes Heloisa Juncklaus Preis , Bressan Luiza Liene
Published: January 2022

Este estudo tem o objetivo de trazer algumas reflexões acerca da instituição da imagem do Mal no imaginário popular. Para tanto, observa-se a ressignificação de elementos associados à ideia do mal a partir da narrativa Balanço Bruxólico, de Franklin Cascaes. Apontamos, ainda, reflexões sobre o feminino e sua relação com o mal, já que a narrativa se reporta às mulheres-bruxas que povoam o imaginário da ilha de Santa Catarina. Pertinentes são, também, alguns conceitos relacionados aos estudos da memória por se tratar de narrativas cuja origem está na memória oral do ilhéu. A pesquisa utiliza como metodologia a hermenêutica simbólica. O estudo torna possível observar a ressignificação de elementos e símbolos da cultura popular para criar a imagem do mal a partir de elementos míticos, envolvendo a questão da mulher-bruxa e a mulher-rezadeira em contraposição entre o mal e o bem. Para este estudo, as pesquisas de Nogueira (2002), Ronecker (1997), Chevalier & Gheerbrant (2015), Durand (2012) entre outros nos servem de âncoras.
INDICADORES FÍSICO-QUÍMICOS Y MICROBIOLÓGICOS EN LA REMOCIÓN DE CONTAMINANTES DE EFLUENTES DE PROCESOS DE TRATAMIENTO SEGUNDARIOS DE AGUAS RESIDUALES AGROINDUSTRIALES Y DOMÉSTICOS
Authors: Vargas Meneses Catalina
Published: January 2022

La investigación trabajo con aguas residuales que se encontraban aún en proceso de descontaminación, no se trabajó ninguna muestra a efluentes.  Las muestras de aguas residuales analizadas proceden de tres distintos tipos de sistemas de tratamiento, todas las muestras se tomaron de la sección del proceso secundario del tratamiento.  Se caracterizaron los tipos de aguas residuales de las aguas crudas del campo en el laboratorio y una porción de la muestra se dispuso en reactores anaerobios y aerobios en condiciones de laboratorio para homogenizar las características de cada agua, para un posterior análisis de agentes microbiológicos que pudieran contener.

La primera etapa consistió en la caracterización físico-química de las muestras de aguas residuales de efluentes de un tratamiento secundario y de los reactores del laboratorio; los resultados se compararon con los estándares costarricenses, para verificar funcionamiento de cada sistema y posterior a esta caracterización se dispusieron diferentes medios de cultivos para determinar coincidencia de microrganismos que pudieran favorecer el proceso de descontaminación, de las aguas crudas y de las tratadas en los reactores del laboratorio.
Papel de la ética y la bioética en enfermería
Authors: Peñaloza-Jaimes Seniet Deyanire
Published: January 2022

Enfermería es una profesión social orientada a la ayuda, al servicio, al cuidado de la salud de las personas (1), es la ciencia y arte de cuidar seres humanos; es decir, el cuidado es la expresión de la actividad profesional buscando garantizar que sea de calidad, digno, efectivo y humanizado (2). El profesional de enfermería, como cualquier otra persona es un ser moral que inconsciente o conscientemente realiza una reflexión ética en cuanto a las acciones sobre la vida humana, en cualquiera de las etapas del ciclo vital. Acciones que se ven influenciadas por diferentes factores internos: conocimientos, habilidades, actitudes, valores y principios; así como factores externos relacionados con el ambiente, formas de trabajo, la organización, la productividad, los adelantos tecnológicos y ahora la misma pandemia por covid-19, de tal manera que las decisiones que se toman frente al cuidado implican no solamente un enfoque biológico, científico y técnico, sino un enfoque ético propio de la disciplina: un enfoque holista y humano del cuidado de enfermería.
Editorial: COVID-19 and its effect on world economy
Authors: Hasan Fakhrul
Published: January 2022

The editorial team is very happy to present the fourth issue of the journal “Risk Governance and Control: Financial Markets & Institutions” in 2021. In this issue, we can see that the authors have done research in different areas of finance. All the topics coved in this issue are very interesting, practical and very timely. This fourth issue covered topics including, firms’ characteristics relation with accounting metrics, future financial crisis, women position in the insurance company, financial liberalisation policies and cryptocurrency.
Verification of Information of the Labeling of Dairy Products of Cartagena de Indias Supermarkets
Authors: Carrascal-Sánchez Juan , Acevedo-Correa Diofanor , Fortich Ana María , Rosano Deniles De Arco , Montero-Castillo Piedad
Published: January 2022

Introduction: Labelling is used to help people choose foods for the nutrients that benefit them most but sometimes the content expressed on the label is not correct. Objective: To compare the data expressed on the labels of the different brands of milk, milk powder, cream, coastal cheese and yogurt with those found in this research. Materials and methods: Samples were taken from local markets, label information was taken, and a bromatological analysis of each product was also performed to compare with the values given by the manufacturer on the label. Results: The values of the parameters declared on the labels in most of the brands analyzed were lower than the actual values found and the data from the Colombian Technical Standard (NTC) and the United States Department of Agriculture (USDA) for each product. To prevent this type of event from continuing, greater control of the companies by the control bodies is necessary. Conclusions: Most valuable dairy products did not comply with national and international labelling rules, as they did not declare, reduce or increase the percentages of most of the parameters on the label.
La Asimetría Cerebral, Retos para la Relación Neuropsicología y Educación
Authors: Gil-Uribe Lina María , Conde-Guzón Pablo Antonio
Published: January 2022

Introducción: El desarrollo de la neurociencia en relación a la educación ha sido desafiante y sus avances. Objetivo: Analizar hermenéutica y sistemática la línea de desarrollo teórico en artículos cualitativos y cuantitativos publicados entre los años 1999 y 2020 de las relaciones entre la asimetría cerebral dentro de las disciplinas: la neuropsicología y la educación. Materiales y métodos: Análisis hermenéutico desarrollado bajo el esquema de la interpretación de los textos primarios y secundarios, evaluados desde la rigurosidad de la hermenéutica en sus cuatro formas de evaluación: “fijación del discurso”; “disociación mental e intención del autor”; “muestra de las referencias no ostensivas” y “universalidad del documento: ¿A quién está dirigido?”. Resultado: La investigación sobre las asimetrías cerebrales (funcionales y anatómicas), especialmente en cuanto al uso de la mano contraria (izquierda o derecha) a la de su lateralidad y su diseminación ha sido limitada e históricamente polarizada haciendo más énfasis en asimetrías cerebrales entendidas desde la influencia fisiológica neurológica y en muestra de resultados desde la actividad cerebral en neuroimágenes. Conclusión: La neuropsicología y la educación en su trabajo sobre las asimetrías cerebrales han estado relacionados a los conceptos médicos: anatomía y fisiología. La “nueva visión” y el surgimiento de especialidades como la neuropsicología, creando la necesidad de dar respuesta a los procesos de aprendizaje y las conexiones existentes entre una y otra.
Cumplimiento de Gobierno Corporativo. un Análisis para Empresas Familiares y no Familiares Colombianas
Authors: Lagos-Cortés Diógenes , López-Vergara María Piedad
Published: January 2022

Introducción. Recientemente el estudio del gobierno corporativo en las empresas familiares ha recibido mayor atención debido al predominio, la importancia y el impacto de estas empresas y a los problemas de agencia que por su estructura se presentan. En este sentido, el gobierno corporativo puede ayudar a las empresas familiares a monitorear eficientemente la gestión para reducir comportamientos oportunistas tanto de los gerentes como de aquellos accionistas que controlan la empresa. Objetivo. Estudiar la relación que se presenta entre el carácter familiar y la adopción de prácticas de gobierno corporativo en empresas listadas en el mercado de valores de Colombia. Materiales y métodos. Se realizó un análisis cuantitativo con datos de panel. Los modelos de regresión fueron estimados mediante efectos aleatorios para tratar la heterogeneidad no observable y las variables omitidas. La muestra correspondió a 479 observaciones-año de 124 empresas listadas en el mercado de valores de Colombia entre 2015 y 2018. Resultados. Se encontró un menor cumplimiento en cuanto a gobierno corporativo en las empresas familiares. Conclusión. El menor cumplimiento en las empresas familiares puede deberse a que estas empresas tienen menores incentivos para implementar buenas prácticas de gobierno corporativo dado que los costos de dicha implementación superan a los posibles beneficios, sumado a que estos beneficios terminan diluyéndose entre todos los accionistas que hacen parte de la familia.
Pre-sincronización con Progesterona para la Inducción de Ciclicidad en Vacas Bos taurus indicus en Periodo de Anestro Posparto
Authors: Botelho-Gomes Tiago , Narváez Héctor Javier
Published: January 2022

Objetivo. Este trabajo tuvo como objetivo evaluar el efecto de la pre-sincronización con progesterona (P4) por 3 y 6 días en vacas de raza Nelore en periodo de anestro posparto, sometidas a un programa de inseminación artificial a tiempo fijo (IATF). Materiales y métodos: Fueron utilizadas 74 vacas multíparas de raza Nelore con estado de condición corporal de 2,5. Las vacas fueron sometidas a tres grupos experimentales, grupo control y grupos pre-sincronizados con P4 por un periodo de 3 y 6 días. Para la determinación del estado de anestro posparto, fueron realizadas ecografías y toma de muestras de sangre con la finalidad de verificar la ausencia de P4 endógena. Cuarenta y cinco días después de la IA fue realizado el diagnóstico de la gestación. Los datos fueron obtenidos por análisis descriptivo y en el caso de presentación de diferencias significativas fue utilizado la prueba de Chi-cuadrado, considerándose una frecuencia de P< 0,05. Resultados: Fue observada mayor tasa de gestación para el grupo que fue pre-sincronizado por tres días con P4 (40 %), con relación a los grupos de seis días de pre-sincronización y control (25 % y 32 %, respectivamente). Conclusión: Es posible concluir que la pre-sincronización con P4 por tres días, mejoró la tasa de gestación de vacas de raza Nelore en periodo de anestro posparto.
Metodología de Análisis de Emociones para Identificar Riesgo de Cometer Suicidio Generado por el COVID-19
Authors: Rodríguez-Esparza Luz Judith , Barraza-Barraza Diana , Salazar-Ibarra Jesús , Vargas-Pasaye Rafael G.
Published: January 2022

Introducción: El comienzo del año 2020 llegó acompañado de una pandemia causada por el virus denominado SARS-CoV-2. Con las medidas de distanciamiento social implementadas para evitar la propagación de este virus, se presentan problemáticas de salud mental, como ansiedad, depresión, etc., trayendo como consecuencia una necesidad de atención a pacientes a distancia. Dadas las cifras alarmantes de incidencias de suicidio en la sociedad actual, aunadas a estas medidas de distanciamiento, son requeridas herramientas de apoyo para identificar individuos en riesgo de cometer suicidio. Objetivo: Proponer y evaluar una nueva metodología para calcular riesgo de suicidio en usuarios de Twitter, apoyándose en el análisis de emociones. Materiales y Métodos: Usando modelos de aprendizaje estadístico (supervisado y no supervisado), la metodología propuesta identifica el nivel de riesgo en el texto analizado de 77 tuits de usuarios regulares y de figuras políticas en México y Latinoamérica. Resultados: Se encontró que, al comparar los métodos utilizados, el porcentaje de coincidencia en clasificación es cercano al 96 %, siendo los métodos supervisado no paramétrico y no supervisado los que detectaron los niveles extremos de riesgo al suicidio. Conclusiones: la metodología propuesta es una herramienta que puede ser de gran apoyo para especialistas del área de salud mental al ayudar a identificar, de manera masiva, la presencia de indicios de enfermedades mentales, para su subsecuente diagnóstico.
Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs
Authors: Seneff Stephanie , Nigh Greg , Kyriakopoulos Anthony M. , McCullough Peter A
Published: January 2022

The mRNA SARS-CoV-2 vaccines were brought to market in response to the
widely perceived public health crises of Covid-19. The utilization of
mRNA vaccines in the context of infectious disease had no precedent, but
desperate times seemed to call for desperate measures. The mRNA vaccines
utilize genetically modified mRNA encoding spike proteins. These
alterations hide the mRNA from cellular defenses, promote a longer
biological half-life for the proteins, and provoke higher overall spike
protein production. However, both experimental and observational
evidence reveals a very different immune response to the vaccines
compared to the response to infection with SARS-CoV-2. As we will show,
the genetic modifications introduced by the vaccine are likely the
source of these differential responses. In this paper, we present the
evidence that vaccination, unlike natural infection, induces a profound
impairment in type I interferon signaling, which has diverse adverse
consequences to human health. We explain the mechanism by which immune
cells release into the circulation large quantities of exosomes
containing spike protein along with critical microRNAs that induce a
signaling response in recipient cells at distant sites. We also identify
potential profound disturbances in regulatory control of protein
synthesis and cancer surveillance. These disturbances are shown to have
a potentially direct causal link to neurodegenerative disease,
myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease,
impaired adaptive immunity, increased tumorigenesis, and DNA damage. We
show evidence from adverse event reports in the VAERS database
supporting our hypothesis. We believe a comprehensive risk/benefit
assessment of the mRNA vaccines excludes them as positive contributors
to public health, even in the context of the Covid-19 pandemic.
Contact sensitization and allergens in the composition of cosmetic products - current knowledge
Authors: Jovanovic Marina
Published: January 2022

Contact sensitivity is a latent state that lasts a lifetime with a clinically
manifesting response in the form of allergic contact dermatitis that often
has an unfavorable prognosis. In contact urticaria syndrome, can cause
anaphylactic reactions. Exposure to irritants or sensitizing factors
represents a major risk. Age and gender are not risk factors for contact
sensitivity in themselves. A recent meta-analysis has shown that the
prevalence of contact sensitivity in the general population is 20.1% and
that 4 allergens from cosmetic products are among the top 6 allergens that
cause contact sensitivity in the general population. Cosmetics products are
responsible for more than half of all allergic contact dermatitis which
mainly affects adults of middle and older age, who generally do not have
atopy and whose occupations have low academic requirements. It is possible
for a cosmetic allergy to develop even after years of using a cosmetic
product without previous problems. Beauty products to watch for. Just
because a label says that something is ?dermatologist tested?, that is no
guarantee that the product will be kind to your skin. There are no rules
about these terms and criteria how to use them on a label. Ingredients that
may cause allergy. Preservatives and fragrances are the most frequently
detected allergens in those with an allergy to a cosmetic product. The
future of allergen labeling. Allergens identified by the Scientific
Committee on Consumer Safety need to be present on a label. Every cosmetic
product placed on the European Union market must have a compliant product
information and an International Fragrance Association certificate if
contains fragrances. Conclusion. Because so-called ?hypoallergenic? products
are not necessarily less sensitizing, allergy departments should distribute
lists of cosmetic products not containing the respective allergen(s) that
consumers can use as safe alternatives.
Binge eating disorder in relation to obsessive-compulsive disorder and food addiction
Authors: Fedrigolli Elsa , Ratkovic Dragana
Published: January 2022

Introduction. Binge eating disorder, as a fairly new disorder, has recently
been added to the Diagnostic and Statistical Manual of Mental Disorders 5,
and it is characterized by recurrent and frequent episodes of eating large
quantities of food in a short time frame. The aim of this study was to
associate binge eating disorder with obsessive-compulsive disorder and food
addiction, which is crucial for understanding and appropriate treatment of
patients. Material and Methods. We reviewed the literature from PubMED
database from January 2000 to May 2021 using the keywords: binge eating
disorder, binge eating disorder and obsessive-compulsive disorder, binge
eating disorder and food addiction, and food addiction, in both English and
German language. Results. Binge eating disorder, as part of the cycle of
obsessive-compulsive disorder, may be considered obsessive thinking about
weight, appearance or bad mood, where hunger and satiation is replaced by
compulsion and loss of control, ritual eating, and secret eating.
Furthermore, binge eating disorder may cause food addiction and this paper
shows that addiction to high sugar and high fat products can lead to
addiction behavior by habituation of certain points in the dorsal nucleus.
This division is of major importance to establish proper treatment
protocols. Conclusion. Binge eating disorder is closely related to
obsessive-compulsive disorder and addiction to behavior and substances.
Further research should focus on identifying the largest subtypes and
classifications of binge eating disorder.
Microstructure and electrical properties of microwave sintered Nb-doped NBT ceramics
Authors: Sahu Rashmirekha , Kumar Pawan
Published: January 2022

Nb5+-doped sodium bismuth titanate (NBT) ceramics
((Na0.5Bi0.5)1-x/2Ti1-xNbxO3 where x = 0, 0.005, 0.01 and 0.015) were
obtained by microwave assisted solid state reaction route and microwave
sintered at 1000 ?C. Microwave processing technique was chosen for the
sintering as it is a powerfulmethod which enables sintering in a short time
with fast heating rate avoiding grain growth. The influence of Nb5+-doping
on microstructure and electrical properties of the NBT ceramics was studied.
X-ray diffraction analyses revealed that solubility limit of niobium in NBT
lattice is up to 1mol%, as with further increase in niobium concentration
pyrochlore appeared. Microstructure of all the ceramics was investigated by
field emission scanning electron microscopy and it was observed that the
average grain size decreased with doping. Temperature dependent dielectric
study was carried out for all the ceramics at different frequency. All
ceramics show diffusive dielectric behaviour around Tm and introduction of
Nb even increases compositional fluctuation compared to the parent NBT.
Nb-doping shifts the Tm toward lower temperature. Leakage current study
showed that for whole range of electric field ohmic type conduction
mechanism is dominant for all the ceramics. Room temperature
polarization-electric field (P-E) hysteresis loop confirms the ferroelectric
behaviour of all the ceramics.
Enhanced low electric-field energy-storage performance in Ba0.9Sr0.1TiO3-Bi(Mg1/2Ti1/2)O3 ceramics
Authors: Wang Shihao , Fang Bijun , Zhang Shuai , Lu Xiaolong , Ding Jianning
Published: January 2022

Perovskite (1-x)Ba0.9Sr0.1TiO3-xBi(Mg1/2Ti1/2)O3 (BST-BiMT-x) ceramics were
prepared by sintering the corresponding powders synthesized by combining of
solid state reaction method with citrate sol-gel and selfcombustion
techniques. Submicron grains morphology, high density and large resistivity
were obtained in the BST-BiMT-x ceramics. In addition, the BST-BiMT-0.1 and
BST-BiMT-0.075 ceramics exhibit ferroelectric hysteresis loops with slim
shape which lead to enhanced energy-storage properties. The energy-storage
density of these two ceramics increases almost linearly with increasing the
applied electric filed. The energy-storage density and efficiency at 25
kV/cm of the BST-BiMT-0.1 and BST-BiMT-0.075 ceramics sintered at 1200?C
are 141.2mJ/cm3 and 79.3%, and 158.1mJ/cm3 and 76.7%, respectively,
surpassing many recently reported values for ferroelectric/antiferroelectric
ceramics. The enhanced energy-storage density and efficiency under low
electric field can be attributed to the slim polarization-electric field
hysteresis loops, high density accompanied by submicron grains morphology
and pure perovskite structure.
Effect of annealing temperature on the characteristic of reduced highly ordered TiO2 nanotube arrays and their CO gas-sensing performance
Authors: Budiman Harry , Wibowo Rahmat , Zuas Oman , Gunlazuardi Jarnuzi
Published: January 2022

A study on the effect of temperature on the reduced highly ordered TiO2
nanotube arrays (reduced-HOTNAs) and their CO gas-sensing performance is
reported. The reduced-HOTNAs were prepared by anodizing method followed by
annealing in the presence of urea at various temperatures (i.e. 450, 500,
550, 600 and 700?C) under N2 atmosphere. The reduced-HOTNAs were
characterized by FTIR, FE-SEM, XRD, UV-Vis DRS, Raman spectroscopy and
photoelectrochemical techniques. The sensing performance of the
reduced-HOTNAs was assessed against CO gas in air mixture. The results show
that the reduced-HOTNAs annealed at 450 ?C (reduced- HOTNAs-450) is a
material with the most significant improvement in sensitivity to detect CO
compared with other reduced-HOTNAs. The reduced-HOTNAs-450 exhibits best
sensing performance at a relatively low CO concentration in the range of
2-25 ppm at 300?C. Findings of this study indicate that improvement of the
reduced-HOTNAs-450 sensitivity might be attributed to the presence of
Ti3+/oxygen vacancy defect and the formation of more active sites on TiO2
surface, making the reduced-HOTNAs-450 a promising active material for CO
gas sensor application.
Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy
Authors: Hu Zizhong , Mao Xiying , Chen Mingkang , Wu Xinjing , Zhu Tianye , Liu Yu , Zhang Zhengyu , Fan Wen , Xie Ping , Yuan Songtao , Liu Qinghuai
Published: January 2022

Vitreous fibrovascular membranes (FVMs), the hallmark of proliferative diabetic retinopathy (PDR), cause retinal hemorrhage, detachment, and eventually blindness. However, little is known about the pathophysiology of FVM. In this study, we used single-cell RNA sequencing on surgically harvested PDR-FVMs and generated a comprehensive cell atlas of FVM. Eight cellular compositions were identified, with microglia as the major cell population. We identified a GPNMB+ subpopulation of microglia, which presented both profibrotic and fibrogenic properties. Pseudotime analysis further revealed the profibrotic microglia was uniquely differentiated from retina-resident microglia and expanded in the PDR setting. Ligand-receptor interactions between the profibrotic microglia and cytokines upregulated in PDR vitreous implicated the involvement of several pathways, including CCR5, IFNGR1, and CD44 signaling, in the microglial activation within the PDR microenvironment. Collectively, our description of the novel microglia phenotypes in PDR-FVM may offer new insight into the cellular and molecular mechanism underlying the pathogenesis of DR, as well as potential signaling pathways amenable to disease-specific intervention.