bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case of Epstein-Barr Virus–Associated Leiomyosarcoma Concurrently With Posttransplant Lymphoproliferative Disorders After Renal Transplantation
Authors: Aida Naohiro , Ito Taihei , Maruyama Michihiro , Saigo Kenichi , Akutsu Naotake , Aoyama Hiromichi , Kitamura Hiroshi , Kenmochi Takashi
Published: July 2019

Epstein-Barr virus (EBV) infection might induce not only posttransplantation lymphoproliferative disorder (PTLD) but also leiomyosarcoma. We report a case of EBV-associated leiomyosarcoma concurrently with PTLD after renal transplantation. The patient was a 30-year-old woman who underwent living donor kidney transplantation at 27 years of age. Preoperative EBV viral capsid antibody immunoglobulin M, immunoglobulin G (IgG), and EBV nuclear antigen IgG were negative. Multiple lung and liver tumors were detected 1.5 years after transplantation. She was diagnosed with PTLD after tumor biopsy. Her EBV DNA was 110 copies/mL detected by real-time polymerase chain reaction when PTLD was diagnosed. She received dose reduction of immunosuppressive therapy and several chemotherapies. Because her hepatic lesion was still progressive while pulmonary lesion was reduced, a liver tumor biopsy was performed, but the biopsy specimens were necrotic. A left lateral segmentectomy was performed as a third biopsy for treatment-resistant hepatic lesion 2.5 years after her first PTLD diagnosis. Pathologically, she was diagnosed with EBV-associated leiomyosarcoma. She was treated with sirolimus, but died 7 months after the operation. This is the first case of the coincidence of leiomyosarcoma associated with EBV and PTLD. This case was exceedingly rare; however, we must consider the coincidence of leiomyosarcoma associated with EBV and PTLD when encountering treatment-resistant PTLD.
Feasibility and efficacy of a web-based family telehealth nutrition intervention to improve child weight status and dietary intake: A pilot randomised controlled trial
Authors: Chai Li Kheng , Collins Clare E , May Chris , Ashman Amy , Holder Carl , Brown Leanne J , Burrows Tracy L
Published: July 2019

Introduction

Innovative eHealth solutions that improve access to child weight management interventions are crucial to address the rising prevalence of childhood obesity globally. The study aimed to evaluate the feasibility and preliminary efficacy of a 12-week online telehealth nutrition intervention to improve child weight and dietary outcomes, and the impact of additional text messages (SMS) targeted to mothers and fathers.

Methods

Families with children aged 4 to 11 were randomised across three groups: Telehealth, Telehealth+SMS, or Waitlist control. Telehealth and Telehealth+SMS groups received two telehealth consultations delivered by a dietitian, 12 weeks access to a nutrition website and a private Facebook group. The Telehealth+SMS group received additional SMS. Feasibility was assessed through recruitment, retention, and intervention utilisation. Efficacy was assessed through changes in measured child body mass index (BMI), waist circumference and diet.

Results

Forty-four (96%) and 36 (78%) families attended initial and second telehealth consultations, respectively. Thirty-six families (78%) completed week 12 assessments. Child BMI and waist circumference changes from baseline to week 12 were not statistically different within or between groups. Children in Telehealth+SMS had significantly reduced percentage energy from energy-dense nutrient-poor food (95% CI −21.99 to −0.03%E; p = .038) and increased percentage energy from healthy core food (95% CI −0.21 to 21.89%E; p = .045) compared to Waitlist control.

Discussion

A family-focused online telehealth nutrition intervention is feasible. While the modest sample size reduced power to detect between-group changes in weight status, some improvements in child dietary intakes were identified in those receiving telehealth and SMS.
Stress-system activation in children with chronic pain: A focus for clinical intervention
Authors: McInnis Peter M , Braund Taylor A , Chua Zhi Kai , Kozlowska Kasia
Published: July 2019

Accumulating evidence indicates that psychological and neurophysiological processes interconnect and interact to activate the body’s stress system and to trigger and maintain functional somatic symptoms. This study used the Early Life Stress Questionnaire, Depression Anxiety Stress Scales and biological markers (heart rate, heart rate variability, skin conductance, C-reactive protein (CRP) titre, respiratory rate, and accuracy and reaction time in an emotion-face identification task), to examine childhood adversity, psychological distress and stress-system activation in 35 children and adolescents (23 girls and 12 boys, 9–17 years old) disabled by chronic pain (vs two groups of age- and sex-matched healthy controls). Patients reported more early-life stress ( U = 798.5, p = .026) and more psychological distress ( U = 978, p < .001). They showed activation of the autonomic system: elevated heart rate ( U = 862.5, p = .003), elevated electrodermal activity ( U = 804.5, p = .024) and lower heart rate variability in the time domain ( U = 380.5, p = .007) and frequency domain ( U = 409.5, p = .017). The group showed an upward shift of CRP titres (with 75th and 90th CRP percentiles of 4.5 and 10.5 mg/L, respectively), suggesting the activation of the immune–inflammatory system. Elevated CRP titres were associated with elevated heart rate ( p = .028). There were no differences in respiratory rate or in accuracy and reaction time in the emotion-face identification task. The results indicate that interventions for children and adolescents with chronic pain need a multidisciplinary mind–body approach that concurrently addresses psychological distress, physical impairment and stress-system dysregulation.
Book review: Keil, R. 2018: Suburban Planet: Making the World Urban from the Outside In. Urban Future Series
Authors: Wu Camille S.
Published: July 2019

Keil, R. 2018: Suburban Planet: Making the World Urban from the Outside In. Urban Future Series. Cambridge: Polity Press. ix + 258 pp. US$64.95 (Hardcover), US$26.50 (Paperback). ISBN: 13: 978-0745683126 (Hardcover). ISBN: 10: 0745683126 (Paperback)
Effects of fuel injection parameters on premixed charge compression ignition combustion and emission characteristics in a medium-duty compression ignition diesel engine
Authors: Molina Santiago , García Antonio , Monsalve-Serrano Javier , Villalta David
Published: July 2019

From the different power plants, the compression ignition diesel engines are considered the best alternative to be used in the transport sector due to its high efficiency. However, the current emission standards impose drastic reductions for the main pollutants, that is, NO x and soot, emitted by this type of engines. To accomplish with these restrictions, alternative combustion concepts as the premixed charge compression ignition are being investigated nowadays. The objective of this work is to evaluate the impact of different fuel injection strategies on the combustion performance and engine-out emissions of the premixed charge compression ignition combustion regime. For that, experimental measurements were carried out in a single-cylinder medium-duty compression ignition diesel engine at low-load operation. Different engine parameters as the injection pattern timing, main injection timing and main injection fuel quantity were sweep. The best injection strategy was determined by means of a methodology based on the evaluation of a merit function. The results suggest that the best injection strategy for the low-load premixed charge compression ignition operating condition investigated implies using a high injection pressure and a triple-injection event with a delayed main injection with almost 15% of the total fuel mass injected.
The analytical incoherence of the multiple modernities thesis
Authors: Sinai Stavit
Published: July 2019

The multiple modernities thesis has been the focus of scholarly debates in the last decade and has become widely accepted in the study of non-Western societies. Yet the thesis suffers from a major incoherence which lies in its principal assumptions about the process by which social change occurs. The article offers a critique of the multiple modernities thesis which challenges Eisenstadt’s understanding of diverse cultural contexts and their localized institutional constellations on account of its dualistic division into two levels: the intangible (ontological visions or culture) and the tangible (structure or system) by which it seeks to account for the plurality of modern societies.
Endovascular Therapy for Distal Superior Mesenteric Artery Mycotic Aneurysms due to Infective Endocarditis
Authors: Higashiura Wataru , Takara Hiroaki , Kitamura Ryoichi , Iraha Tomotaka , Nakasu Akio , Ishimine Tohru , Yasutani Tadashi , Wake Minoru , Tengan Toshiho
Published: July 2019

Purpose: To report 3 patients with infective endocarditis who underwent transcatheter arterial embolization for mycotic aneurysm of the distal superior mesenteric artery (SMA). Case Report: Three men (60, 64, and 65 years old) were diagnosed with infective endocarditis. Antibiotics were initiated immediately after admission and continued for several weeks to months. Distal SMA mycotic aneurysm was identified on computed tomography in the vicinity of the ileocolic artery at 33, 26, and 30 days after admission. In case 1, the ileal artery was occluded distal to the aneurysm, with collateral flow to the ileum. In case 2, the mycotic aneurysm was located below the ileocolic artery, which was stenosed distal to the lesion. In case 3, the aneurysm was located on a branch of the ileal artery. Transarterial embolization using microcoils was successfully performed in all patients. No complications associated with embolotherapy or relapse of infection were observed in these 3 patients at 60, 30, and 15 months, respectively. Conclusion: Transcatheter arterial embolization for distal SMA mycotic aneurysm could provide an alternative to open surgery. Anatomical assessment of collateral flow and preprocedure long-term antibiotic therapy could play important roles in preventing bowel ischemia and minimizing the risk of infection relapse.
Diffusion coefficient calculated by complementary error function for the sublimation diffusion of disperse dye
Authors: Park Geon Yong
Published: July 2019

In order to find a simple and reliable method for the calculation of the diffusion coefficient, the correlation equation of concentration and distance in the form of complementary error function was derived from solving an ordinary differential equation of the diffusion equation. A disperse dye in paste was treated at 170°C–190°C for 3–4 h for the sublimation diffusion into polyethylene terephthalate using a film roll method. Quadratic regression analysis on the profile of dye concentration–distance was used to determine the surface concentration. The diffusion coefficient of each layer was calculated by obtaining the variable value of the complementary error function from the ratio of the mean dye concentration of each layer to the surface concentration. From linear regression analysis on the Arrhenius plot of the logarithm of the diffusion coefficient versus the reciprocal of absolute temperature, the correlation coefficient for the diffusion of 3 h was 0.9978 and that of 4 h was 0.9991. Thus, it was expected that the diffusion coefficients determined by the equation of complementary error function adopted in this experiment were reliable. The activation energy of diffusion for 3 h was 30.5 kcal mol−1 and that for 4 h was 27.4 kcal mol−1.
Safety and efficacy of the use of large bore intermediate suction catheters alone or in combination for the treatment of acute cerebral venous sinus thrombosis: A multicenter experience
Authors: Dandapat Sudeepta , Samaniego Edgar A , Szeder Viktor , Siddiqui Fazeel M , Duckwiler Gary R , Kiddy Ume , Guerrero Waldo R , Zheng Binbin , Hasan David , Derdeyn Colin , Ortega-Gutierrez Santiago
Published: July 2019

Background and purpose

Systemic anticoagulation is the standard treatment for cerebral venous sinus thrombosis (CVST). Several endovascular techniques have been described as salvage therapy for anticoagulation refractory CVST cases. We aim to evaluate the safety and feasibility of endovascular aspiration thrombectomy using the new generation, large bore suction catheters alone or in combination with stentriever devices for the treatment of CVST.

Methods

We collected data on 16 consecutive patients with CVST who received endovascular aspiration thrombectomy at three large academic centers. Second generation reperfusion catheters were used as a large bore suction catheter and advanced to the affected sinus using a coaxial technique. Suction was performed using pump suction. At times, a stentriever was used as an anchor to facilitate advancing the suction catheter and to increase thrombectomy capabilities.

Results

Median decade of age was the 50s and nine patients were women. Fifty percent of the patients had multiple sinuses involved. All patients received systemic anticoagulation prior to endovascular aspiration thrombectomy. The most common reason to pursue endovascular aspiration thrombectomy in CVST patients was deterioration of initial clinical status (10/16). The mean time from admission to endovascular aspiration thrombectomy was 1.5 days (range 0–6 days). Good recanalization was obtained in all patients. There were no major peri-procedural complications. Most patients were discharged to either home or a rehabilitation facility.

Conclusion

Endovascular aspiration treatment using large bore suction catheters for CVST is a safe and feasible approach for the treatment of anticoagulation refractory CVST. Heterogeneity of the clinical and radiological presentation requires further investigation to optimize patient selection before evaluating the efficacy of this technique in larger prospective studies.
Synthesis of novel chiral fluorescent sensors and their application in enantioselective discrimination of chiral carboxylic acids
Authors: Yu Qiuhan , Lu Weiwen , Ding Zhiqiang , Wei Min , Dai Zhenya
Published: July 2019

Novel chiral fluorescent sensors are synthesized from a dibromide containing a tetraphenylethylene moiety and enantiomerically pure amino alcohols and an amine. The sensors are applied for the chiral recognition of a wide range of chiral carboxylic acids and related derivatives.
Female hair loss
Authors: Middleton David W , McCourt Collette
Published: July 2019

Hair loss in female patients is a distressing condition. Patients can present to GPs for assessment, advice and consideration of onward referral. A wide range of disorders can lead to hair loss in females. This article will outline common disorders and their clinical features, including investigation and management strategies for primary and secondary care. A sound understanding of the course and prognosis of diseases allows open discussion with patients during healthcare consultations, and is important given the distressing nature of hair loss.
Metabolic syndrome
Authors: McNamara Anthony
Published: July 2019

Metabolic syndrome is the name given to a combination of cardiovascular risk factors. These include hyperinsulinaemia, impaired glucose tolerance, hypertension, central obesity and dyslipidaemia. People with metabolic syndrome have a high risk of developing type 2 diabetes, non-alcoholic fatty liver disease, and vascular conditions including coronary artery disease, peripheral vascular disease, and stroke. Central obesity can predispose to sleep apnoea and restrictive lung disease. For many years, it has been taught that the underlying mechanism of metabolic syndrome is insulin resistance secondary to obesity and inactivity, however, this somewhat simplistic model fails to accurately describe the complex interaction between three key factors: glucose, insulin and cortisol. This article will explain our current understanding of metabolic syndrome and how to treat it.
Surgical Trends in the Treatment of Lisfranc Injuries Using the American Board of Orthopaedic Surgery (ABOS) Certification Examination Database
Authors: Raja Avais , Pena Fernando
Published: July 2019

Background: Lisfranc joint complex injury may be managed surgically by either an open reduction internal fixation (ORIF) or primary arthrodesis (PA). Published literature advocates PA for purely ligamentous injuries, but many surgeons in actuality refrain from performing PA. The purpose of the study is to assess surgeon practices and behavior in managing Lisfranc injuries due to the influence of peer reviewed literature with the help of the American Board of Orthopaedic Surgery (ABOS) database. Methods: Data were requested from the ABOS database of cases on Lisfranc joint injury requiring either an ORIF or PA from examination year 2004 to 2017 for both part II and maintenance of certification (MOC) examinees. Cases with ICD-9 code 838.03 only were considered as primarily ligamentous and all fracture codes classified under 825 with 838.03 were considered as fracture dislocation. The number of PA and ORIF were recorded for both types of examinees and specific type of Lisfranc joint injury (primarily ligamentous and fracture dislocation). Results: A total of 2010 cases of Lisfranc joint injuries managed surgically by 1230 board-eligible orthopaedic surgeons. Open fractures (93) and non-/malunion fractures were excluded. A total of 1016 primarily ligamentous and 474 fracture dislocation cases were performed by part II examinees. Overall, 288 primarily ligamentous and 139 fracture dislocation cases were performed by MOC examinees. A total of 27 PA were performed in the primarily ligamentous and 17 were performed on fracture dislocation cases. Conclusion: ORIF is commonly performed by newly trained and senior orthopaedic surgeons. There was no change in the number of PA performed on primarily ligamentous injuries in spite of the published literature.

Levels of Evidence: Not applicable
A Framework for Research in Transition: Identifying Important Areas and Intersections for Future Study
Authors: Trainor Audrey A. , Carter Erik W. , Karpur Arun , Martin James E. , Mazzotti Valerie L. , Morningstar Mary E. , Newman Lynn , Rojewski Jay W.
Published: July 2019

The role of research in transition education has been prominent and influential. Yet too many young people with disabilities are still not experiencing outcomes aligned with their personal aspirations and priorities. Moreover, individuals with disabilities continue to experience barriers to employment, educational, economic, and other challenges well into adulthood. Moving forward as a field will require continued investment in strong scholarship and careful consideration of new areas of inquiry. In this article, we present a framework for transition research designed to identify key issues and intersections in which future inquiry should be directed. We present research needs in six different areas to illustrate these possibilities. We also highlight some of the complexities and considerations associated with conducting this research.
Utility of a Novel Biomimetic Spine Model in Surgical Education: Case Series of Three Cervicothoracic Kyphotic Deformities
Authors: Bohl Michael A. , McBryan Sarah , Kakarla U. Kumar , Leveque Jean-Christophe , Sethi Rajiv
Published: July 2019

Study Design:

Evaluation of new technology.

Objectives:

To evaluate the utility of a novel biomimetic spine model as a surgical planning and education resource in the treatment of cervical spine deformities (CSD).

Methods:

Three patients with CSD were identified and synthetic spine models were manufactured to match the anatomical and biomechanical properties of each patient. Each model underwent 3 phases of surgical correction: maximum correction with no osteotomies performed, with posterior column osteotomies (PCOs) only, and with PCOs and a 3-column osteotomy (3CO). Lateral fluoroscopic films were obtained after each phase of correction for measurement of cervical lordosis. Surgeons were surveyed to obtain subjective feedback on the perceived model utility.

Results:

Each model began with a kyphotic deformity that was mobile, rigid, or fixed. The mobile model achieved successive lordotic correction with each phase of correction. The rigid and fixed models achieved much less correction with no osteotomies and PCOs only, and the majority of correction with 3COs. Each model predicted with varying, but overall high, accuracy the amount of correction achieved in each patient. The surgeons felt the model had very high utility as a surgical education platform.

Conclusions:

The models appeared to accurately replicate the gross anatomy and biomechanical performance of the patients’ spines. This high fidelity to the individual patient’s anatomy, bone quality, and segmental mobility resulted in a custom model that provides an invaluable learning platform for surgical education. These results suggest the models may have utility in surgical planning, but further studies are needed.
Monitoring treatment response in metastasic colorectal cancer: Economic evaluation of PrediCTC versus computed tomography scan
Authors: Antón Rodríguez Cristina , Abal Posada Miguel , Alonso Alconada Lorena , Candamio Folgar Sonia , López López Rafael , Martín-Saborido Carlos
Published: July 2019

Background: Late state colorectal cancer treatments have important side effects that should be avoided in patients where drug effectiveness is not adequate. PrediCTC is a new biomarkers blood test developed to determinate the chemotherapy response in unresectable metastatic colorectal cancer patients that could allow to obviate unnecessary treatments. Aim: To assess from the Spanish Societal Perspective the cost-utility of the test PrediCTC compared to the computed tomography in aim to evaluate chemotherapy treatment response in late stage colorectal cancer patients. Methods: Based on the results of Barbazán et al., a Markov model has been developed, in which the different lines and cycles that the colorectal patient can receive and how they can move between them according to the computed tomography or PrediCTC have been represented. The effectiveness has been expressed in quality adjusted life years (QALYs), avoiding adverse events. Results: Base case analysis shows savings in different types of costs for PrediCTC (per patient): €14.30 in those arise from adverse events, €22,345.73 in chemotherapy costs, €4849.61 in other direct costs, and €306.21 in indirect costs. Although computed tomography 12-week assessed patients gain 0.17 QALYs compared with PrediCTC. Conclusions: From the Spanish Societal Perspective, PrediCTC is not a cost-utility option but allows to identify earlier patients who are not benefiting from first-line chemotherapy avoiding unnecessary side effects and costs.
Towards Sustainable Computer-assisted Legal Research in Nigerian Law Faculties: Exploring the Nexus between User Education, Intrinsic Motivation and Use of Electronic Law Databases
Authors: Ajala Anuoluwa Maria
Published: July 2019

Despite the inclusion of legal research in academic curriculum of law programmes in universities, some factors are still capable of militating against the acquisition of legal research skills by law students. Every law faculty in Nigeria teaches legal research skills to their students, but there are still signs of poor legal research skills by law graduates in Nigeria, which is reflected in their inability to find the legal information that is relevant in the practice of the legal profession. It is argued that computer-assisted legal research entails a process in which electronic law information resources are indispensable. One of the electronic law information resources is the electronic law database. The use of electronic law databases is indeed crucial to legal research. However, lack of user education may lead to lack of intrinsic motivation to use electronic databases. In Nigerian law faculties, a lot of funds are invested in provision of electronic information resources in order to promote legal research among law students. However, the relationship between user education and use of electronic law databases may or may not justify the funds invested. This article explicates the place of computer-assisted legal research in law faculties and reveals that there is a need for law students to be intrinsically motivated to use electronic law databases. This article also exhibits additional measures that Nigerian law faculties can take in order to motivate law students to use the electronic law databases.
Screening for pulmonary arterial hypertension in systemic sclerosis
Authors: Weatherald Jason , Montani David , Jevnikar Mitja , Jaïs Xavier , Savale Laurent , Humbert Marc
Published: July 2019

Pulmonary arterial hypertension (PAH) is a dreaded complication of systemic sclerosis (SSc) that occurs in ∼10% of patients. Most individuals present with severe symptoms, significant functional impairment and severe haemodynamics at diagnosis, and survival after PAH diagnosis is poor. Therefore, early diagnosis through systematic screening of asymptomatic patients has the potential to identify PAH at an early stage. Current evidence suggests that early diagnosis and treatment of PAH in patients with SSc may lead to better clinical outcomes. Annual screening may include echocardiography, but this can miss some patients due to suboptimal visualisation or insufficient tricuspid regurgitation. Other options for screening include the DETECT algorithm or the use of a combination of pulmonary function testing (forced vital capacity/diffusing capacity of the lung for carbon monoxide ratio) and N-terminal-pro-brain natriuretic peptide levels. Symptomatic patients, those with an elevated tricuspid regurgitation velocity on echocardiogram with or without secondary echocardiographic features of PAH, and those who screen positive on the DETECT or other pulmonary function test algorithms should undergo right heart catheterisation. Exercise echocardiography or cardiopulmonary exercise testing, nailfold capillaroscopy and molecular biomarkers are promising but, as yet, unproven potential options. Future screening studies should employ systematic catheterisation to define the true predictive values for PAH.
Obstructive sleep apnoea in acute coronary syndrome
Authors: Randerath Winfried , Bonsignore Maria R. , Herkenrath Simon
Published: July 2019

Obstructive sleep apnoea (OSA) syndrome affects about 13% of the male and 7–9% of the female population. Hypoxia, oxidative stress and systemic inflammation link OSA and cardiovascular and metabolic consequences, including coronary artery disease. Current research has identified several clinical phenotypes, and the combination of breathing disturbances during sleep, systemic effects and end-organ damage might help to develop personalised therapeutic approaches. It is unclear whether OSA is a risk factor for acute coronary syndrome (ACS) and might affect its outcome. On the one hand, OSA in patients with ACS may worsen prognosis; on the other hand, OSA-related hypoxaemia could favour the development of coronary collaterals, thereby exerting a protective effect. It is unknown whether positive airway pressure treatment may influence adverse events and consequences of ACS. In non-sleepy patients with OSA and stable coronary artery disease, randomised controlled trials failed to show that continuous positive airway pressure (CPAP) treatment protected against cardiovascular events. Conversely, uncontrolled studies suggested positive effects of CPAP treatment in such patients. Fewer data are available in subjects with ACS and OSA, and results of randomised controlled studies on the effects of CPAP are expected shortly. Meanwhile, the search for reliable markers of risk continues. Recent studies suggest that daytime sleepiness may indicate a more severe OSA phenotype with regard to cardiovascular risk. Finally, some studies suggest sex-related differences. The picture is still incomplete, and the potential role of OSA in patients with ACS awaits confirmation, as well as clear definition of subgroups with different degrees of risk.
Pore structure and fluid uptake of the Yeso, Abo, and Cisco Formations in the Permian Basin in southeast New Mexico, USA
Authors: Hu Qinhong , Mann Griffin , Zhao Jianhua
Published: July 2019

There is a need for a petrophysical understanding of producing formations in the Northwest Shelf in southeast New Mexico. Working with six rotary sidewall core samples (dolomite, limestone, and sandstone), we have investigated the utility of mercury injection capillary pressure (MICP), contact angle, fluid imbibition, as well as logging analyses to evaluate the characteristics of pore structure and fluid uptake of the Yeso (Paddock and Blinebry members), Abo, and Cisco Formations. Results from MICP tests provide a variety of pore structure data including bulk and particle densities, porosity, pore-throat size distribution, permeability, and tortuosity. Two Abo dolomite samples indicate the highest porosities at greater than 15%, compared with 4%–7% for the other two dolomite samples from the Paddock and Blinebry members within the Yeso Formation. Most of the pore-throat sizes for these samples fall within the range of [Formula: see text]. The only exceptions are the Paddock member sample, which possesses a higher percentage of larger pores ([Formula: see text]), and the dolomite sample from the Cisco Formation, which has most of its pore-throat sizes falling within the range of [Formula: see text]. From contact angle measurements, all samples are found to be oil-wet because n-decane spreads onto the rock surface much quicker than the other hydrophilic fluids (deionized water and brine). Imbibition tests reveal well-connected pore networks in all samples, with the highest values of imbibition slopes being recorded for the Abo samples. In addition, we used the crossplot of porosity and water saturation obtained from log analyses to derive a value for permeability at field scales. The porosity and permeability values, from log analyses as well as laboratory MICP and gas pycnometry-permeameter measurements, and at different observational scales, are generally consistent. The overall results provide a snapshot of the pore structure characteristics, from limited samples but using integrated approaches and scales, of these formations.
Depth migration with the near surface: A case study for mineral exploration in China
Authors: Liu Guofeng , Meng Xiaohong , Liu Yu
Published: July 2019

Seismic reflection data used in mineral exploration are usually of poor quality because of rough topography and small-scale heterogeneities. However, there is an increasing demand for accurate imaging processes that can obtain such data. Here, we have developed a practical rugged depth migration method based on the finite-difference one-way wave equation. It can be used to improve imaging quality when faced with rough topography and complex geologic features. First, synthetic data are used to illustrate the errors and problems that cause unsatisfactory imaging results. This is usually because no consideration is given to rough topography during conventional processing procedures. To address this, a depth migration method that begins with the rugged topography is introduced. It can be used to produce better images. Real data from mineral exploration activities in Fujian, China, are then used to demonstrate the practical use of this method. We also compare two computational processes: The first corrects the data back to the original surface and then builds a velocity model before conducting rugged depth migration; the second process involves performing rugged depth migration on processed data featuring a smoothed surface following short-wavelength static correction and residual correction. The imaging results indicate that the section obtained from the processed data has better quality. They also indicate that the imaging quality of the original surface is affected by the built velocity model, which cannot include near-surface and small-scale structures.
Characterization of mass transport deposits using seismic attributes: Upper Leonard Formation, Permian Basin
Authors: Bhatnagar Paritosh , Verma Sumit , Bianco Ron
Published: July 2019

The Permian Basin is a structurally complex sedimentary basin with an extensive history of tectonic deformation. As the basin evolved through time, sediments dispersed into the basin floor from surrounding carbonate platforms leading to various mass movements. One such mass movement is observed on a 3D seismic survey in the Upper Leonard interval (Lower Permian) of the Midland Basin that is characteristic of a mass transport deposit (MTD). The 350 ft thick MTD mapped in the study area is 5 mi wide, extends up to 14 mi basinward, and covers only the translational and compressional regime of the mass movement. A unique sedimentary feature, unlike those observed previously, is mapped and interpreted as gravity spreading. MTDs have been extensively studied in the Delaware Basin of Permian-aged strata; however, only a few works have been published on the geomorphological expression of MTDs using seismic and seismic attributes to delineate the shape, size, and anatomy of this subsurface feature. The MTD in the study area exhibits an array of features including slide, slump, basal shear surface, and MTD grooves. In cross section, the MTD is characterized as chaotic with semitransparent reflectors terminating laterally against a coherent package of seismic facies, or the lateral wall. Sobel filter-based coherence, structural curvature, dip magnitude, and dip azimuth attributes are used to map thrust faults within the discontinuous MTD. Kinematic evidence provided by the Upper Spraberry isopach suggests that this MTD was sourced north of the Midland Basin and deposited on the basin floor fairway. Slope strata are interpreted from well-log analysis showing MTD as a mixture of carbonates and siliciclastics with a moderate to high resistivity response.
Applying integrated seismic technology to complex foothill areas of foreland basins in China
Authors: Fang Yong , Luo Wenshan , Luo Xiaoxia , Feng Xukui , Zhao Bo , Jia Wenrui
Published: July 2019

Due to complicated near-surface conditions, including large elevation changes and complex geologic structures, accurate imaging of subsurface structures for hydrocarbon exploration in the foreland basins of western China has been challenging for many years. After decades of research and fieldwork, we developed an effective seismic exploration workflow that uses the latest technologies from acquisition to imaging. They include 3D high-density and wide-azimuth (WAZ) acquisition, 3D true-surface tilted transverse isotropy (TTI) anisotropic prestack depth migration, and dual-detachment structural modeling and interpretation. To further reduce uncertainty in velocity model building and improve imaging quality, our geologists, geophysicists, and reservoir engineers worked closely through the exploration cycle (seismic acquisition, processing, and interpretation). This exploration model has been used successfully in hydrocarbon exploration of many complex foothill areas in western China. Three-dimensional WAZ high-density seismic surveys have been conducted over 40,000 km2of the foreland basins, greatly improving the field seismic data quality. After application of 3D true-surface TTI anisotropic depth model building and imaging with integrated structural interpretation, new discoveries of hydrocarbon reservoirs have increased. The application of new technologies not only increased drilling success but also reduced depth well-tie errors between seismic data and wells.
Frictions in a Competitive, Regulated Market: Evidence from Taxis
Authors: Fréchette Guillaume R. , Lizzeri Alessandro , Salz Tobias
Published: July 2019

This paper presents a dynamic equilibrium model of a taxi market. The model is estimated using data from New York City yellow cabs. Two salient features by which most taxi markets deviate from the efficient market ideal are, first, matching frictions created by the need for both market sides to physically search for trading partners, and second, regulatory limitations to entry. To assess the importance of these features, we use the model to simulate the effect of changes in entry, alternative matching technologies, and different market density. We use the geographical features of the matching process to back out unobserved demand through a matching simulation. The matching function exhibits increasing returns to scale, which is important to understand the impact of changes in this market and has welfare implications. For instance, although alternative dispatch platforms can be more efficient than street-hailing, platform competition is harmful because it reduces effective density. (JEL C78, L51, L84, L92, L98, R48)
Who Pays for the Minimum Wage?
Authors: Harasztosi Peter , Lindner Attila
Published: July 2019

This paper provides a comprehensive assessment of the margins along which firms responded to a large and persistent minimum wage increase in Hungary. We show that employment elasticities are negative but small even four years after the reform; that around 75 percent of the minimum wage increase was paid by consumers and 25 percent by firm owners; that firms responded to the minimum wage by substituting labor with capital; and that disemployment effects were greater in industries where passing the wage costs to consumers is more difficult. We estimate a model with monopolistic competition to explain these findings. (JEL J23, J24, J31, J38, L13)
Identification of and Correction for Publication Bias
Authors: Andrews Isaiah , Kasy Maximilian
Published: July 2019

Some empirical results are more likely to be published than others. Selective publication leads to biased estimates and distorted inference. We propose two approaches for identifying the conditional probability of publication as a function of a study’s results, the first based on systematic replication studies and the second on meta-studies. For known conditional publication probabilities, we propose bias-corrected estimators and confidence sets. We apply our methods to recent replication studies in experimental economics and psychology, and to a meta-study on the effect of the minimum wage. When replication and meta-study data are available, we find similar results from both.(JEL C13, C90, I23, J23, J38, L82)
Radiation therapy for oligometastatic oropharyngeal cancer
Authors: Martini Stefania , Arcadipane Francesca , Franco Pierfrancesco , Iorio Giuseppe C. , Bartoncini Sara , Gallio Elena , Guarneri Alessia S. , Ricardi Umberto
Published: July 2019

At presentation, isolated metastasis from oropharyngeal squamous cell carcinoma is rare. Liver is a relatively uncommon first site of failure, especially in the absence of other distant metastases, particularly without diagnosis of lung metastases. We report on a case of HPV-related oropharyngeal squamous cell carcinoma with synchronous liver metastasis treated with radiation therapy. This condition, defined as "oligometastatic state," describes a subset of patients with limited volume metastatic disease in whom favorable outcomes were reported with the use of local ablative therapies on both the primary tumor and metastatic sites. As a definitive treatment, we offered the patient, ineligible for other therapeutic approaches, exclusive radiation treatment on the head and neck region and a stereotactic ablative approach targeted to the liver metastasis.
Recent advances in managing fecal incontinence
Authors: Da Silva Giovanna , Sirany Anne
Published: July 2019

Fecal incontinence (FI) is the uncontrolled passage of feces or gas in an individual who previously had control. The prevalence of the problem varies but can be as high as 50% of institutionalized individuals. The severity varies among individuals, but the negative impact on self-esteem and quality of life can have devastating effects. The goals of treatment are to decrease the frequency and severity of episodes as well as to improve quality of life. At present, several therapies, ranging from medical management to more invasive surgical interventions, are offered for the management of FI. In this article, we review the most recent advances in the management of FI.
Polygenic risk scores in psychiatry: Will they be useful for clinicians?
Authors: Fullerton Janice M. , Nurnberger John I.
Published: July 2019

Major psychiatric disorders are heritable but they are genetically complex. This means that, with certain exceptions, single gene markers will not be helpful for diagnosis. However, we are learning more about the large number of gene variants that, in combination, are associated with risk for disorders such as schizophrenia, bipolar disorder, and other psychiatric conditions. The presence of those risk variants may now be combined into a polygenic risk score (PRS). Such a score provides a quantitative index of the genomic burden of risk variants in an individual, which relates to the likelihood that a person has a particular disorder. Currently, such scores are quite useful in research, and they are telling us much about the relationships between different disorders and other indices of brain function. In the future, as the datasets supporting the development of such scores become larger and more diverse and as methodological developments improve predictive capacity, we expect that PRS will have substantial clinical utility in the assessment of risk for disease, subtypes of disease, and even treatment response. Here, we provide an overview of PRS in general terms (including a glossary suitable for informed non-geneticists) and discuss the use of PRS in psychiatry, including their limitations and cautions for interpretation, as well as their applications now and in the future.
Interactions between the hippocampus, prefrontal cortex, and amygdala support complex learning and memory
Authors: Yavas Ersin , Gonzalez Sarah , Fanselow Michael S.
Published: July 2019

One of the guiding principles of memory research in the preceding decades is multiple memory systems theory, which links specific task demands to specific anatomical structures and circuits that are thought to act orthogonally with respect to each other. We argue that this view does not capture the nature of learning and memory when any degree of complexity is introduced. In most situations, memory requires interactions between these circuits and they can act in a facilitative manner to generate adaptive behavior.
SAFE: A Comprehensive Data Visualization System
Authors: Basdere Mehmet , Caniglia Gabriel , Collar Charles , Rozolis Christian , Chiampas George , Nishi Michael , Smilowitz Karen
Published: July 2019

Short abstract: The authors discuss SAFE, a comprehensive data visualization system that enhances logistics, medical preparedness, and responses for mass-participation endurance events such as marathons.
Optimal Design of Efficient Rooftop Photovoltaic Arrays
Authors: Udell Madeleine , Toole Oliver
Published: July 2019

The authors address the automated design of cost-effective, efficient rooftop photovoltaic (PV) installations. The algorithm they present can design systems with a variety of solar hardware and has been used to create more than 70,000 designs for PV installations.
Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin-
3-yl)prop-2-en-1-ones and Their Antimicrobial Activity
Authors: Subrahmanyam Relangi Siva , Anna Venkateswara Rao
Published: July 2019

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.
Parliamentary Questions: Expressions of Opposition(s) within the European Parliament?
Authors: Kaniok Petr , Komínková Magda
Published: July 2019

Parliamentary questions are a direct form of parliamentary scrutiny of other EU institutions and bodies, traditionally being an important tool for the opposition. This study examines how parliamentary questions are used in the European Parliament. We ascertain whether political groups representing opposition differ in their use of parliamentary questions from those who are represented in the European Commission. The article presents two main findings. First, such a difference does exist in all types of questions at the aggregated level. Groups not represented in the European Commission pose more questions than those who are represented. Secondly, it appears that the type of parliamentary question determines the groups’ behaviour. The article thus contributes to our understanding of how opposition functions in the European Parliament.
The Place of Objects and Things in the Age of Materiality
Authors: Brückner Martin
Published: July 2019

This essay reprises the status of objects in relation to critical conversations that favor things and thing studies over other methodologies of material culture studies. Recent discussions have dismissed objects as passive foils that lack in meaning. Glossing the factor of representation, however, these discussions have also glossed over a factor crucial in shaping the way in which the distinction between objects and things is made accessible in theory and practice. Two examples taken from eighteenth-century American literary culture, an anecdote by Benjamin Franklin and a sales ad published by the Pennsylvania Gazette, illustrate how in the process of representation objects become imbued with significance that reaches beyond mere signification and object classification. Once conceived as ‘material signs,’ objects become participants in cognitive environments in which seemingly meaningless symbols foster meaningful engagement with materiality.
Differential Expression of VGLUT2 in Mouse Mesopontine Cholinergic Neurons
Authors: Steinkellner Thomas , Yoo Ji Hoon , Hnasko Thomas S.
Published: July 2019

Vesicular glutamate transporters (VGLUTs) mediate the synaptic uptake of glutamate from the cytosol into synaptic vesicles and are considered unambiguous neurochemical markers of glutamate neurons. However, many neurons not classically thought of as glutamatergic also express a VGLUT and co-release glutamate. Using a genetic fate-mapping strategy we found that most cholinergic neurons in the mouse mesopontine tegmentum express VGLUT2 at some point during development, including the pedunculopontine tegmental nucleus (PPTg), laterodorsal tegmental nucleus, and parabigeminal nucleus (PBG), but not the oculomotor nucleus. In contrast, very few of these cholinergic neurons displayed evidence of vesicular GABA transporter expression. Using multiplex fluorescentin situhybridization, we determined that only PBG cholinergic neurons are also predominantly positive for VGLUT2 mRNA in the adult, with only small numbers of PPTg cholinergic neurons overlapping with VGLUT2 mRNA. Using Cre-dependent viral vectors we confirm thesein situhybridization data, and demonstrate projection patterns of cholinergic and glutamatergic populations. These results demonstrate that most mesopontine cholinergic neurons may transiently express VGLUT2, but that a large majority of PBG neurons retain VGLUT2 expression throughout adulthood, and support a growing body of literature indicating that distinct cholinergic populations have differing potential for GABA or glutamate co-release.