bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma
Authors: Ramos Carlos A. , Grover Natalie S. , Beaven Anne W. , Lulla Premal D. , Wu Meng-Fen , Ivanova Anastasia , Wang Tao , Shea Thomas C. , Rooney Cliona M. , Dittus Christopher , Park Steven I. , Gee Adrian P. , Eldridge Paul W. , McKay Kathryn L. , Mehta Birju , Cheng Catherine J. , Buchanan Faith B. , Grilley Bambi J. , Morrison Kaitlin , Brenner Malcolm K. , Serody Jonathan S. , Dotti Gianpietro , Heslop Helen E. , Savoldo Barbara
Published: July 2020

PURPOSE

Chimeric antigen receptor (CAR) T-cell therapy of B-cell malignancies has proved to be effective. We show how the same approach of CAR T cells specific for CD30 (CD30.CAR-Ts) can be used to treat Hodgkin lymphoma (HL).

METHODS

We conducted 2 parallel phase I/II studies (ClinicalTrials.gov identifiers: NCT02690545 and NCT02917083 ) at 2 independent centers involving patients with relapsed or refractory HL and administered CD30.CAR-Ts after lymphodepletion with either bendamustine alone, bendamustine and fludarabine, or cyclophosphamide and fludarabine. The primary end point was safety.

RESULTS

Forty-one patients received CD30.CAR-Ts. Treated patients had a median of 7 prior lines of therapy (range, 2-23), including brentuximab vedotin, checkpoint inhibitors, and autologous or allogeneic stem cell transplantation. The most common toxicities were grade 3 or higher hematologic adverse events. Cytokine release syndrome was observed in 10 patients, all of which were grade 1. No neurologic toxicity was observed. The overall response rate in the 32 patients with active disease who received fludarabine-based lymphodepletion was 72%, including 19 patients (59%) with complete response. With a median follow-up of 533 days, the 1-year progression-free survival and overall survival for all evaluable patients were 36% (95% CI, 21% to 51%) and 94% (95% CI, 79% to 99%), respectively. CAR-T cell expansion in vivo was cell dose dependent.

CONCLUSION

Heavily pretreated patients with relapsed or refractory HL who received fludarabine-based lymphodepletion followed by CD30.CAR-Ts had a high rate of durable responses with an excellent safety profile, highlighting the feasibility of extending CAR-T cell therapies beyond canonical B-cell malignancies.
Risk of Atherosclerotic Cardiovascular Diseases in various Ethnicities of Pakistan
Authors: Ashraf Tariq , Nadeem Asif , Sarwar Shakil , Karim Musa
Published: July 2020

Objective: To estimate the risk of atherosclerotic cardiovascular diseases (ASCVD) in various ethnicities of Pakistan using Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) risk calculator and the Pooled Cohort Equations (PCE).

Methods: Individuals of both gender between 40 to 65 years of age without pre-existing coronary artery disease from residents of Karachi were recruited through snowball sampling technique. Study was conducted at the National Institute of Cardiovascular Diseases, Karachi, Pakistan during January to June 2019. Ethnicity of the participants was categorized based on their mother tongue. Ten-year risk of ASCVD event was estimated using Astro-CHARM Calculator and PCE.

Results: Mean age of a total of 386 individuals was 49(±7.1) years and 45.3% (175) were females. Urdu-speaking individuals were 33.4%(129) of the sample, while, 18.4%(71) Pushtoons, 14%(54) Sindhi, 13%(50) Punjabi, 2.6%(10) Balochi, and remaining 18.7%(72) were of other ethnicities. High risk (≥7.5%) individuals were 20.7% (80/386) as per PCE and 11.1% (43/386) as per Astro-CHARM. As per Astro-CHARM, Sindhis’ had the least risk of ten-years ASCVD event among all the ethnicities, while, Urdu-speakings’ had the highest risk with mean rank of 145.18 vs. 216.50, p-value=0.001.

Conclusion: A significant 10-years risk of first ASCVD event was observed in our population. ASCVD risk is alarmingly high in some ethnicities, such as Urdu-speaking, owing to the increased prevalence of traditional modifiable risk factors, such as diabetes and smoking.

doi: https://doi.org/10.12669/pjms.36.6.2618

How to cite this:Ashraf T, Nadeem A, Sarwar S, Karim M. Risk of Atherosclerotic Cardiovascular Diseases in various Ethnicities of Pakistan. Pak J Med Sci. 2020;36(6):1158-1164. doi: https://doi.org/10.12669/pjms.36.6.2618

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Some useful tips to detect Gift Authorship
Authors: Jawaid Shaukat Ali , Jawaid Masood
Published: July 2020

doi: https://doi.org/10.12669/pjms.36.6.3154

How to cite this:Jawaid SA, Jawaid M. Some useful tips to detect Gift Authorship. Pak J Med Sci. 2020;36(6):1145-1146.  doi: https://doi.org/10.12669/pjms.36.6.3154
Recent advances in understanding and managing hypoparathyroidism
Authors: Rubin Mishaela R.
Published: July 2020

Hypoparathyroidism is a rare endocrine disorder which leads to hypocalcemia, hypercalciuria, and hyperphosphatemia. Complications include nephrocalcinosis with renal dysfunction, reduced quality of life, and abnormal skeletal properties. Conventional therapy with calcium and vitamin D analogs addresses hypocalcemia but has important limitations. Parathyroid hormone (PTH) therapy is a fundamental advance, although the effects of PTH on long-term complications require additional testing. Continuous PTH therapy is likely to be particularly advantageous for addressing renal, quality of life, and skeletal complications. Overall, much progress has been made, yet more information is needed to improve our understanding and management of hypoparathyroidism.
An ontology-based modelling system (OBMS) for representing behaviour change theories applied to 76 theories
Authors: Hale Joanna , Hastings Janna , West Robert , Lefevre Carmen E. , Direito Artur , Bohlen Lauren Connell , Godinho Cristina , Anderson Niall , Zink Silje , Groarke Hilary , Michie Susan
Published: July 2020

Background: To efficiently search, compare, test and integrate behaviour change theories, they need to be specified in a way that is clear, consistent and computable. An ontology-based modelling system (OBMS) has previously been shown to be able to represent five commonly used theories in this way. We aimed to assess whether the OBMS could be applied more widely and to create a database of behaviour change theories, their constructs and propositions.

Methods: We labelled the constructs within 71 theories and used the OBMS to represent the relationships between the constructs. Diagrams of each theory were sent to authors or experts for feedback and amendment. The 71 finalised diagrams plus the five previously generated diagrams were used to create a searchable database of 76 theories in the form of construct-relationship-construct triples. We conducted a set of illustrative analyses to characterise theories in the database.

Results: All 71 theories could be satisfactorily represented using this system. In total, 35 (49%) were finalised with no or very minor amendment. The remaining 36 (51%) were finalised after changes to the constructs (seven theories), relationships between constructs (15 theories) or both (14 theories) following author/expert feedback. The mean number of constructs per theory was 20 (min. = 6, max. = 72), with the mean number of triples per theory 31 (min. = 7, max. = 89). Fourteen distinct relationship types were used, of which the most commonly used was ‘influences’, followed by ‘part of’.

Conclusions: The OBMS can represent a wide array of behavioural theories in a precise, computable format. This system should provide a basis for better integration and synthesis of theories than has hitherto been possible.
Resource-saving plasma technology in the repair of processing equipment
Authors: Kravchenko Igor' , Glinskiy Maksim , Karcev Sergey , Korneev Viktor , Abdumuminova Diana
Published: July 2020

In the monograph methodological bases of selection of method of coating, design of technological processes of hardening and recovery of the wearing surfaces of parts using a systems engineering analysis and information support technologist. The mathematical model of plasma spraying of materials with different thermal conductivity and methods criteria for evaluation of technical and technological opportunities of a plasma coating method. Describes the methods and results of experimental studies, the analysis of the conditions and causes of loss of efficiency of processing equipment APK. The proposed scientific and methodical approach to the justification of expediency of the recovery and strengthening of the working bodies and parts expensive imported technological equipment. The proposed mathematical model describing the physical processes in plasma coating for various applications. The structure of the algorithm for solving the task of hardening and recovery of worn parts plasma methods on the basis of the integrated CAE system.
This monograph is intended for employees of scientific research institutions, specialists of machine-building production and enterprises of technical service, as well as teachers, postgraduates and students of agricultural engineering areas of training.
PESQUISA PARTICIPANTE E COMUNICAÇÃO DIALÓGICA: A experiência com as comunidades ciganas da Espanha
Authors: Marques Gonçalves Gabriela
Published: July 2020

Este artigo tem como objetivo discutir como a comunicação dialógica pode ser aplicada em trabalhos de campo de pesquisas participantes. Se realizará, por tanto, uma discussão teórica sobre esta metodologia de pesquisa, seguida da reflexão sobre sua aplicação no caso específico das comunidades ciganas. O âmbito prático da pesquisa se enfocará na realidade destas comunidades na Espanha, a partir do relato da nossa experiência de trabalho durante quatro anos no referido país. Como resultados, apontamos a importância do conhecimento de seus contextos históricos e sociais para construir um entorno dialógico de pesquisa, bem como a participação ativa em suas lutas para alcançar uma melhor compreensão das realidades analisadas.
Nietzsche e o ensino-aprendizado de filosofia: a necessidade do encontro para a comunicação dialógica
Authors: Couto Rita de Cassia Santos , Campello Cristie
Published: July 2020

A decisão do governo do Rio de Janeiro de impor a modalidade a distância nas escolas públicas de ensino médio em plena pandemia gera preocupação. Como professora de filosofia da rede pública do estado, identifico, pelo menos, dois problemas principais no ensino-aprendizado de filosofia a distância: primeiro, não é possível aprender e ensinar filosofia de forma efetiva exclusivamente por meio de ferramentas digitais; e segundo, essa modalidade de ensino não alcança todos os envolvidos. Para demonstrar esse entendimento, analiso os escritos de Nietzsche sobre a crítica da dualidade corpo e mente. A partir disso, reflito sobre a importância do encontro no ensino-aprendizado de filosofia, propondo um espaço de comunicação dialógica em que é possível reconhecer a diferença, estimular a criação e promover a autossuperação.
COMUNICAÇÃO DIALÓGICA E DIREITOS “QUASE-HUMANOS”
Authors: Dias Luciene De Oliveira
Published: July 2020

Depois de 70 anos da Declaração Universal dos Direitos Humanos e mais de 30 anos da Constituição Federal Brasileira, ainda é importante identificarmos ameaças à concretização dos direitos elementares e, paralelamente, buscar alianças para assegurá-los. Nesta luta pela defesa de direitos, a comunicação dialógica combate a “pedagogia da crueldade” (SEGATO, 2014) que coloca alguns grupos como humanos e outros como “quase-humanos” (KRENAK, 2019). Aqui, propomos uma reflexão que (re)aproxima a comunicação da perspectiva dialógica acionada pelo educador brasileiro Paulo Freire (2005). Ao rejeitar a necropolítica e fazer a defesa do bem-viver, tendo a educação como mediadora, apostamos na construção do respeito às diferenças. Para sustentar nossas discussões, lançamos mão da experiência de oferta do componente curricular “Cidadania e Direitos Humanos” para o curso de Jornalismo da Universidade Federal de Goiás. Esta experiência explicitou uma pauta que parecia esquecida quando falamos em formação profissional para jornalistas. Os resultados apontam que estudantes lançam mão da comunicação dialógica para posicionar-se contra a violação dos Direitos Humanos desde os seus primeiros momentos de formação.
Gênero sob ataque: resistências emergentes
Authors: Pereira Camila Santos , Pereira Anamaria Ladeira
Published: July 2020

Análise crítica do documentário peruano Gênero sob ataque (2018), que apresenta uma série de entrevistas e eventos que tensionaram os debates sobre identidade de gênero e orientação sexual, em quatro países latino-americanos, Costa Rica, Peru, Colômbia e Brasil. Além disso, são retratados no filme os avanços reacionários financiados por lideranças políticas e religiosas, cujo campo de disputas concentrou-se nos espaços escolares. Sob ataques constantes, os movimentos feministas e LGBTTQI+ fazem parte desse cenário de embates e resistências.
Impaction technique influences implant stability in low-density bone model
Authors: Doyle Ruben , van Arkel Richard J. , Muirhead-Allwood Sarah , Jeffers Jonathan R. T.
Published: July 2020

Aims

Cementless acetabular components rely on press-fit fixation for initial stability. In certain cases, initial stability is more difficult to obtain (such as during revision). No current study evaluates how a surgeon’s impaction technique (mallet mass, mallet velocity, and number of strikes) may affect component fixation. This study seeks to answer the following research questions: 1) how does impaction technique affect a) bone strain generation and deterioration (and hence implant stability) and b) seating in different density bones?; and 2) can an impaction technique be recommended to minimize risk of implant loosening while ensuring seating of the acetabular component?

Methods

A custom drop tower was used to simulate surgical strikes seating acetabular components into synthetic bone. Strike velocity and drop mass were varied. Synthetic bone strain was measured using strain gauges and stability was assessed via push-out tests. Polar gap was measured using optical trackers.

Results

A phenomenon of strain deterioration was identified if an excessive number of strikes was used to seat a component. This effect was most pronounced in low-density bone at high strike velocities. Polar gap was reduced with increasing strike mass and velocity.

Conclusion

A high mallet mass with low strike velocity resulted in satisfactory implant stability and polar gap, while minimizing the risk of losing stability due to over-striking. Extreme caution not to over-strike must be exercised when using high velocity strikes in low-density bone for any mallet mass. Cite this article: Bone Joint Res 2020;9(7):386–393.
From core to higher surgical training: influence of surgical education contracts and induction boost
Authors: Robinson DBT , Hopkins L , Brown C , Bowman C , Abdelrahman T , Iorwerth A , Hemington-Gorse S , Pollitt MJ , Egan RJ , Lewis WG
Published: July 2020

The primary focus of core surgical training is for trainees to attain a higher surgical training number. The aim of this study is to determine the factors associated with success at UK national training number (NTN) selection.

Can a scoring system better national selection and contribute to career progression?
Designing the phase and amplitude of scalar optical fields in three dimensions
Authors: Aborahama Yousuf , Dorrah Ahmed H. , Mojahedi Mo
Published: July 2020

The ability to generate any arbitrarily chosen optical field in a three-dimensional (3D) space, in the absence of any sources, without modifying the index of refraction, remains an elusive but much-desired capability with applications in various fields such as optical micromanipulation, imaging, and data communications, to name a few. In this work, we show analytically that it is possible to generate any desired scalar optical field with predefined amplitude and phase in 3D space, where the generated field is an exact duplicate of the desired field in case it is a solution of Helmholtz wave equation, or if the existence of such field is strictly forbidden, the generated field is the closest possible rendition of the desired field in amplitude and phase. The developed analytical approach is further supported via experimental demonstration of optical beams with exotic trajectories and can have a significant impact on the aforementioned application areas.
Broadband 2.7  µm mid-infrared emissions in Er3+-doped PbO–PbF2–Bi2O3–Ga2O3 glasses
Authors: Yu Jin , Zhang Meng , Lu Xiaosong , Du Yanqiu , Brambilla Gilberto , Jia Shijie , Wang Shunbin , Wang Pengfei
Published: July 2020

Broadband emission at 2.7 µm is observed in an

E
r

3
+

-doped

P
b
O

−

P
b
F

2

−

B
i

2

O

3

−

G
a

2

O

3

glass. The measured emission band full-width-at-half-maximum (FWHM) is

∼

184.4

n
m

, approximately 36 nm wider than that of fluoride glasses. The 2.7 µm emission intensity is almost twice as strong as that of fluoride glasses. The peak values of emission and absorption cross-sections are calculated to be

1.54

×

10

−
20

c
m

2

and

1.19

×

10

−
20

c
m

2

, respectively. This oxyfluoride heavy metal glass shows potential as broadband mid-infrared emission gain material.
SI-traceable molecular transition frequency measurements at the 10−12 relative uncertainty level
Authors: Reed Z. D. , Long D. A. , Fleurbaey H. , Hodges J. T.
Published: July 2020

Accurate and spectroscopic measurements of molecular transition
frequencies are increasingly being employed in a variety of rigorous
tests of physics, including the validity of quantum electrodynamics,
the proton–electron mass ratio, and the dipole moment of the electron.
Near-infrared molecular transitions may also underpin secondary
frequency standards for length metrology and provide convenient
wavelength standards for telecommunication and spectroscopy. To report
progress in this field, we describe measurements of near-infrared
Doppler-broadened carbon dioxide line positions. Our experiment uses
cavity ring-down spectroscopy in the linear domain and provides an
accurate International System of Units (SI)-traceable frequency axis
via active locking of the probe laser and ring-down cavity to a
Cs-clock-referenced optical frequency comb. The approach has several
key attributes: the ability to rapidly scan the probe laser while
maintaining a phase lock to the optical frequency comb, continuously
tunable spectrum frequency axes that are not limited by the cavity
mode spacing, and high signal-to-noise-ratio spectra resulting in
stationary statistics amenable to long-term averaging. This
performance is achieved by phase locking a single-mode probe laser to
the optical frequency comb, coherent electro-optical phase modulation
for rapid cavity mode-to-mode shifting of the probe laser, and
sub-kilohertz-level frequency stabilization of the ring-down cavity
relative to the probe laser. We report vacuum transition frequencies
of five transitions in the

(

30012

)
←
(

00001

)

vibrational band of

12

C

16

O

2

near 1.57 µm and achieve combined
standard uncertainties as low as 212 Hz, corresponding to a relative
combined standard uncertainty near

10

−
12

.
The Effects of Exogenous Polyamines and the Silencing of RLCK VI_A Kinases on the Polar Growth of Nicotiana tabacum (Tobacco) Pollen Tubes
Authors: Jee Shyam
Published: July 2020

Several genetic and/or environmental factors such as air, temperature, humidity can have a harmful effect on fruit- and seed-set in seed plants. To minimize the harmful effect of these factors, it is important to get more information on the underlying genetics and physiology of pollen biology, including pollen viability and the regulation of pollen germination and tube growth, which is required to increase the safety of crop productivity (Abdelgadir, Johnson, and Staden 2012). In this thesis, two different experimental approaches were described to better understand the role of polyamines and plant-specific kinases (RLCK VI_A), respectively, on pollen tube germination and growth in Nicotiana tabacum.
Individualized Surgical Management in the Head and Neck Region
Authors: Lóderer Zoltán
Published: July 2020

The surgical management of malignant tumors or in the head and neck region often leads to functional and esthetic defects that impair the quality of life of the patients. Reconstruction can be solved with prostheses in these cases, but various types of microsurgical free flaps can provide a better clinical outcome. Not only head and neck cancer and related surgical interventions, but also trauma and congenital cranio-maxillofacial deformities can result in appearance, which may impair the socialization or social integration of the patient. These special cases indicate special consideration and surgical techniques. The aim of the current thesis is to present the importance of the individualized surgical management through special cases.
Characterisation and practical importance of exerciseinduced cardiovascular response in a 6 - to 18-year-old population
Authors: Havasi Katalin
Published: July 2020

- Haemodynamic effect also has individual (fitness and health specifics) and population-level (public health impact) relevance to exercise. - Confirmed evidence about the pupils: differences exist between recovery HR and recovery BP trends: recovery HR remained at a high level, in contrast, the recovery BP decreased to starting level or below. - Established a pilot, exercise-related screening test, called “Fit-test”. It provides an opportunity to gain new insight into the relationship between later manifestations of illness and juvenile burden response.  Fit-test is a low-budget, whole-population screening test, which easily fits into an existing school and school health system.  We have found that is also suitable for screening for MHT, preHT, and sustained HT students, and for monitoring the effects of treatment. - We established a database, the first large dataset of haemodynamic changes of normal-weight pupils during a field exercise test.  We defined the population-specific dynamics and experienced individual dissimilarities.  It provided an opportunity to evaluate the physical and cardiovascular fitness together.  Established a possibility for subsequent monitoring of the health status of the affected generation, and risk group. This dataset is useful for physical education teachers, coaches, physicians and exercise physiologists to evaluate actual cardiovascular fitness and haemodynamic responses to exercise in children or adolescents and follow its change.
Home Infliximab Infusions Are Associated With Suboptimal Outcomes Without Cost Savings in Inflammatory Bowel Diseases
Authors: Giese-Kim Nozomi , Wu May , Dehghan Melody , Sceats Lindsay A. , Park K.T.
Published: July 2020

INTRODUCTION:

Biologic agents including infliximab are effective but costly therapies in the management of inflammatory bowel disease (IBD). Home infliximab infusions are increasingly payer-mandated to minimize infusion-related costs. This study aimed to compare biologic medication use, health outcomes, and overall cost of care for adult and pediatric patients with IBD receiving home vs office- vs hospital-based infliximab infusions.

METHODS:

Longitudinal patient data were obtained from the Optum Clinformatics Data Mart. The analysis considered all patients with IBD who received infliximab from 2003 to 2016. Primary outcomes included nonadherence (≥2 infliximab infusions over 10 weeks apart in 1 year) and discontinuation of infliximab. Secondary outcomes included outpatient corticosteroid use, follow-up visits, emergency room visits, hospitalizations, surgeries, and cost outcomes (out-of-pocket costs and annual overall cost of care).

RESULTS:

There were 27,396 patients with IBD (1,839 pediatric patients). Overall, 5.7% of patients used home infliximab infusions. These patients were more likely to be nonadherent compared with both office-based (22.2% vs 19.8%; P = .044) and hospital-based infusions (22.2% vs 21.2%; P < .001). They were also more likely to discontinue infliximab compared with office-based (44.7% vs 33.7%; P < .001) or hospital-based (44.7% vs 33.4%; P < .001) infusions. On Kaplan-Meier analysis, the probabilities of remaining on infliximab by day 200 of therapy were 64.4%, 74.2%, and 79.3% for home-, hospital-, and office-based infusions, respectively (P < .001). Home infliximab patients had the highest corticosteroid use (cumulative corticosteroid days after IBD diagnosis: home based, 238.2; office based, 189.7; and hospital based, 208.5; P < .001) and the fewest follow-up visits. Home infusions did not decrease overall annual care costs compared with office infusions ($49,149 vs $43,466, P < .001).

DISCUSSION:

In this analysis, home infliximab infusions for patients with IBD were associated with suboptimal outcomes including higher rates of nonadherence and discontinuation of infliximab. Home infusions did not result in significant cost savings compared with office infusions.
Mass Screening for Celiac Disease: The Autoimmunity Screening for Kids Study
Authors: Stahl Marisa G. , Geno Rasmussen Cristy , Dong Fran , Waugh Kathleen , Norris Jill M. , Baxter Judith , Yu Liping , Steck Andrea K. , Frohnert Brigitte I. , Liu Edwin , Rewers Marian J. ,   the ASK Study Group
Published: July 2020

INTRODUCTION:

The Autoimmunity Screening for Kids (ASK) study is a large scale pediatric screening study in Colorado for celiac disease (CD) and type 1 diabetes. This is a report of the CD outcomes for the first 9,973 children screened through ASK.

METHODS:

ASK screens children aged 1–17 years for CD using 2 highly sensitive assays for tissue transglutaminase autoantibodies (TGA): a radiobinding (RBA) assay for IgA TGA and an electrochemiluminescence (ECL) assay that detects all TGA isotypes. Children who test positive on either assay are asked to return for confirmatory testing. Those with a confirmed RBA TGA level ≥ 0.1 (twice the upper limit of normal) are referred to the Colorado Center for Celiac Disease for further evaluation; all others are referred to primary care.

RESULTS:

Of the initial 9,973 children screened, 242 children were TGA+ by any assay. Of those initially positive, 185 children (76.4%) have completed a confirmation blood draw with 149 children (80.5%) confirming positive by RBA TGA. Confirmed RBA TGA+ was associated with a family history of CD (odds ratio [OR] = 1.83; 95% confidence interval 1.06–3.16), non-Hispanic white ethnicity (OR = 3.34; 2.32–4.79), and female sex (OR = 1.43; 1.03–1.98). Gastrointestinal symptoms of CD, assessed at the initial screening, were reported equally often among the RBA TGA+ vs TGA− children (32.1% vs 30.5%, P = 0.65).

DISCUSSION:

The initial results of this ongoing mass-screening program confirm a high prevalence of undiagnosed CD autoimmunity in a screened US population. Symptoms at initial screening were not associated with TGA status (see Visual abstract, Supplementary Digital Content 5, http://links.lww.com/AJG/B587).
UMA PROPOSTA DE GERENCIAMENTO DE PROJETOS DE QUALIDADE APLICADO AO MODELO LEAN EM UMA EMPRESA DE LATAS DE ALUMÍNIO
Authors: Arcanjo de Melo Michele , Santos Alves Juliana , Luiz Fernandes José
Published: July 2020

Esse trabalho propõe uma integração do modelo de gerenciamento de projetos,segundo PMI, com foco em qualidade integrando com a metodologia de Lean,baseando-se nas informações obtidas de uma Empresa Multinacional de Latas deAlumínio, denominada de Empresa A. Os indicadores de processo utilizados naEmpresa são baseados na estratégia da Empresa. A integração será propostatendo em vista a necessidade do aprimoramento do gerenciamento dos projetosde melhoria realizados na Empresa. Espera-se atingir um melhor controle do ge-renciamento de projetos na Empresa A, pois os projetos eram gerenciados combase no PDCA, de modo que os resultados não tinham um indicador definido. E,a partir da integração do gerenciamento de projetos de qualidade com lean, ociclo PDCA será substituído pelo DMAIC dentro do gerenciamento de projetos dequalidade a fim de melhor atingir os objetivos estratégicos através dos indicadores gerados.
Epistemologies of the Body in Colonial Manila's Film Culture
Authors: Trice Jasmine Nadua
Published: July 2020

This article explores the contradictions that surrounded evocations of the clean, hygienic, healthy body in 1920s and 1930s Manila film culture, where moviegoing ephemera such as advertisements, exhibition artifacts, and popular media interfaced with other systems of knowledge implicated within the colonial project, such as bodily piety and public health. This juncture between consumer culture, cinema, and discourses of cleanliness places the cinema within an uncanny archive of aspirational embodiment that evokes older orders of power: accounts of cinemagoing measured theaters' worth in terms of sanitation and cleanliness; and in both English and Tagalog popular film magazines, advertisements for doctors, medicines, cleaning agents, and beauty products sat beside images of local and foreign stars. Circulating within a context of impending independence and cultural transition, this archive not only bolstered US colonial regimes of hygiene, sanitation, cleanliness, gender, and race, but also evoked residual formations of religious piety and Catholicism.
Spirit, Writer
Authors: Huber Sandra
Published: July 2020

Automatic writing, or spirit writing, introduces a hidden feminist media history that puts into question the role of the author, divisions between automaticity and creativity, and the porosity of the (writing) body. In the nineteenth century, a predominantly female labor force began channeling spirits and producing scripts that were either entirely authorless or profoundly collaborative, a practice not so much about inscribing as de-inscribing. This article focuses on medium Geraldine Cummins, who brought her ghosts and guides into a court of law, revealing how the most ordinary tools of writing can be encountered as uncanny and talismanic presences. Her techniques of radical listening invite explorations of live-ness, presence, able-ness, and receptivity—themes that the article extends to the work of contemporary feminist artists and the illegible scripts of AI. How does automatic writing complicate the role of bodies who write as well as bodies of writing?
Somewhere between Human, Nonhuman, and Woman
Authors: Mukherjee Debashree
Published: July 2020

In 1939, at the height of her stardom, the actress Shanta Apte went on a spectacular hunger strike in protest against her employers at Prabhat Studios in Poona, India. The following year, Apte wrote a harsh polemic against the extractive nature of the film industry. In Jaau Mi Cinemaat? (Should I Join the Movies?, 1940), she highlighted the durational depletion of the human body that is specific to acting work. This article interrogates these two unprecedented cultural events—a strike and a book—opening them up toward a history of embodiment as production experience. It embeds Apte's emphasis on exhaustion within contemporaneous debates on female stardom, industrial fatigue, and the status of cinema as work. Reading Apte's remarkable activism as theory from the South helps us rethink the meanings of embodiment, labor, materiality, inequality, resistance, and human-object relations in cinema.
The Theory and Practice of Eclecticism in Eighteenth-Century European Architecture
Authors: Neville Kristoffer
Published: July 2020

In The Theory and Practice of Eclecticism in Eighteenth-Century European Architecture, Kristoffer Neville links an early modern method of eclectic thought to contemporary architectural theory and practice. The eclectic mode promoted the selection and combination of elements from different traditions to create new work, work ostensibly more perfect than the individual sources on which it was based. A related approach has long been acknowledged in major projects by the architects Johann Bernhard Fischer von Erlach, Nicodemus Tessin the Younger, and Balthasar Neumann, all active in the first half of the eighteenth century, but a conceptual basis for this commonality has not been recognized. Neville excavates the intellectual foundations of seventeenthand eighteenth-century eclecticism and shows how these were absorbed into architectural theory, articulating a concept that was widely valued in the German lands during the eighteenth century.
From Outcast to Citizen:
Authors: Park Sun-Young
Published: July 2020

Enlightenment-era France gave rise to the world’s first deaf and blind schools: the Institute for Deaf-Mutes, founded in 1760, and the Institute for Blind Youth, founded in 1784. During the 1789 Revolution, both schools were nationalized, and disability education became the duty of the state. Housed at first in private homes and various government-expropriated properties, the two institutions eventually received renovated or rebuilt quarters in the decades after the Revolution. These projects, designed by the well-known architects Antoine- Marie Peyre and Pierre Philippon, remain overlooked in the history ofmodern architecture. In FromOutcast to Citizen: Disability, Education, and Architecture in Postrevolutionary Paris, Sun-Young Park argues that these institutions were at the forefront of contemporary discourses on education and hygiene and were key sites for the development and testing of new ideas about citizenship and social progress in the postrevolutionary era.
Identification of Genetic Variants Associated With Myocardial Infarction in Saudi Arabia
Authors: AI-Ghalayini Kamal W , Salama Mohammed A. , Al Mahdi Hadia Bassam , Al-Harthi Sameer , Alhejily Wesam A , Alasnag Mirvat A , Tasbhji Noura O , Al-Quwaie Diana A. H , Deloukas Panos , Edris Sherif
Published: July 2020

The genetic variants associated with various genetic disorders have not been identified decisively in Saudi Arabia. Among these variants, six known for their association with coronary artery disease or myocardial infarction (MI) were studied on Saudi patients. Reference single nucleotide polymorphisms (SNPs) of these variants are rs5174, rs11591147, rs2259816, rs111245230, rs3782886 and rs2259820, referring to genes LRP8, PCSK9, HNF1A, SVEP1, BRAP and HNF1A, respectively. The analysis employed polymerase chain reaction panel coupled with mini-sequencing (SNapShot multiplex system) in order to identify these variants. A total of 100 MI patients and 103 healthy control individuals participated in this study. The six variants (SNPs) were evaluated for the risk of developing MI in the Saudi patients. Analysis of allele frequencies indicated that A allele of rs11591147 variant can be a protective allele, thus, is associated with the decreased risk of MI in Saudi individuals. Rare allele of rs111245230 variant (e.g., C allele) was extremely reduced, while rare allele of rs3782886 variant (e.g., G allele) does not exist in the ethnic signature of the Saudi population. This study elucidates the possible prediction of risk factors associated with severe diseases in Saudi population utilizing SNapShot multiplex system.
Genome Resequencing, Improvement of Variant Calling, and Population Genomic Analyses Provide Insights into the Seedlessness in the GenusVitis
Authors: Kim Myung-Shin , Hur Youn Young , Kim Ji Hong , Jeong Soon-Chun
Published: July 2020

The seedlessness of grape derived from stenospermocarpy is one of the most prized traits of table or raisin grapes. It is controlled by a complex genetic system containing one dominant gene and multiple recessive genes. Here, we collected dense variation data from high-depth resequencing data of seeded, seedless, and wild relative grape genomes sequenced to > 37x mean depth. Variant calls were made using a modified variant calling pipeline that was suitable for highly diverse interspecific grape accessions. The modified pipeline enabled us to call several million more variants than the commonly recommended pipeline. The quality was validated by Sanger sequencing data and subsequently supported by the genetic population structure and the phylogenetic tree constructed using the obtained variation data, results of which were generally consistent with known pedigree and taxonomic classifications. Variation data enabled us to confirm a dominant gene and identify recessive loci for seedlessness. Incidentally, we found that grape cultivar Rizamat contains an ancestral chromosomal region of the dominant gene in Sultanina, a predominant seedlessness donor cultivar. Furthermore, we predicted new candidate causal genes including Vitvi01g00455, Vitvi08g01528, and Vitvi18g01237 associated with the recessive seedless-regulating loci, which showed high homology with genes that regulate seed development in Arabidopsis. This study provides fundamental insights relevant to variant calling from genome resequencing data of diverse interspecific hybrid germplasms such as grape and will accelerate future efforts aimed at crop improvement.
Toward User Interfaces and Data Visualization Criteria for Learning Design of Digital Textbooks
Authors: RAILEAN Elena
Published: July 2020

User interface and data visualisation criteria are central issues in digital textbooks design. However, when applying mathematical modelling of learning process to the analysis of the possible solutions, it could be observed that results differ. Mathematical learning views cognition in on the base on statistics and probability theory, graph theory, game theory, cellular automata, neural networks etc. Instead of this, research methodologies in learning design are diversified in behaviourism, cognitive, constructivism and connexionism. Behaviourism aims to promote observable behavior, but placing the responsibility for learning on the shoulders of teachers and/or textbooks' content. The cognitive and social psychology adds value to the systems theory and place the responsibility to mental structures of students' cognitive systems. Constructivism aims to support multiple perspectives or interpretations of reality, knowledge construction, context-rich, experience-based activities and focused on didactic activities. The connectionism models are based on mental or behavioral phenomena as the emergent processes of interconnected networks of simple units. These trends could be analysed on the base on linear, systems and Meta-Systems approaches. This article is a review of user interface and data visualisation criteria as a demonstration of Meta-Systems Learning Design in Digital Textbooks use and development.
Collaborative Learning: Group Interaction in an Intelligent Mobile-Assisted Multiple Language Learning System
Authors: TROUSSAS Christos , VIRVOU Maria , ALEPIS Efthimios
Published: July 2020

This paper proposes a student-oriented approach tailored to effective collaboration between students using mobile phones for language learning within the life cycle of an intelligent tutoring system. For this reason, in this research, a prototype mobile application has been developed for multiple language learning that incorporates intelligence in its modeling and diagnostic components. One of the primary aims of this research is the construction of student models which promote the misconception diagnosis. Furthermore, they are the key for collaboration, given that students can cooperate with their peers, discuss complex problems from various perspectives and use knowledge to answer questions and/or to solve problems. Summarizing, in this paper, a mobile tutoring framework, built up in the context of student collaboration, is presented. Collaborative student groups are created with respect to the corresponding user models. Finally, the prototype was evaluated and the results confirmed the usefulness of collaborative learning.
Intrauterine Device Use in Adolescents With Disabilities
Authors: Schwartz Beth I. , Alexander Morgan , Breech Lesley L.
Published: July 2020

BACKGROUND AND OBJECTIVES:

Intrauterine devices (IUDs) are increasingly being used in adolescents and nulliparous women for contraception. Levonorgestrel IUDs also have beneficial effects on bleeding and pain. Although they are recommended for menstrual suppression in adolescents with disabilities, there are limited data on their use in this population. Our objective is to describe the characteristics and experiences of levonorgestrel IUD use in nulliparous children, adolescents, and young adults with physical, intellectual, and developmental disabilities.

METHODS:

A retrospective chart review was conducted for all nulliparous patients ages ≤22 with physical, intellectual, or developmental disabilities who had levonorgestrel IUDs placed between July 1, 2004, and June 30, 2014, at a tertiary-care children’s hospital. Descriptive statistical analysis and survival analysis were performed.

RESULTS:

In total, 185 levonorgestrel IUDs were placed in 159 patients with disabilities. The mean age was 16.3 (3.3; range of 9–22) years. Only 4% had ever been sexually active; 96% of IUDs were inserted in the operating room. IUD continuation rate at 1 year was 95% (95% confidence interval: 93%–100%) and at 5 years was 73% (95% confidence interval: 66%–83%). The amenorrhea rate was ∼60% throughout the duration of IUD use among those with available follow-up data. Side effects and complications were ≤3%.

CONCLUSIONS:

In this study, we provide evidence for the therapeutic benefit and safety of levonorgestrel IUD use in adolescents and young adults with physical, intellectual, and developmental disabilities. It should be considered as a menstrual management and contraceptive option for this population.
Sistemática del género neotropical Brassavola (Orchidaceae)
Authors: Noguera-Savelli Eliana
Published: July 2020

El género Brassavola pertenece a la subtribu Laeliinae (Orchidaceae); crece en tierras bajas, desde México hasta el norte de Argentina. La similitud vegetativa y floral de las plantas ha dificultado la delimitación de las especies. En esta investigación se analizó la sistemática de Brassavola, mediante el uso de caracteres morfológicos. La metodología que se siguió fue revisión de material de herbario y vivo, y revisión de literatura botánica especializada. Producto de este estudio se genera un tratamiento taxonómico donde se reconocen catorce especies de Brassavola que pueden ser fácilmente diferenciadas con base en caracteres florales del labelo y la columna.
Aportes a la morfología, reproducción y ecología de Loxopterygium grisebachii (Anacardiaceae)
Authors: Zapater María A. , Aquino Víctor H. , Del Castillo Elvio M. , Lozano Evangelina C.
Published: July 2020

Loxopterygium grisebachii (Anacardiaceae) es una especie suramericana endémica de Argentina y Bolivia calificada en la Lista Roja de UICN como vulnerable. Es característica del Chaco serrano y de la Selva Pedemontana de Yungas y desde el punto de vista biogeográfico es un importante constituyente de los Bosques Tropicales Secos Estacionales del Neotrópico en los Núcleos de Piedemonte. Por la importancia de la especie es notable que los trabajos taxonómicos sean incompletos, el sistema sexual no está bien definido, no hay referencias sobre aspectos reproductivos y se detectan inconsistencias sobre los datos de distribución y características ecológicas, lo que impide desarrollar acciones para proteger sus poblaciones. El objetivo fue ampliar el conocimiento macro y micro-morfológico de la especie, conocer aspectos reproductivos como sistema sexual, sistema reproductivo, éxito reproductivo y conocer mejor su distribución y ecología. Se estudiaron colecciones particulares y públicas incluyendo ejemplares tipo. El estudio morfológico se desarrolló con técnicas tradicionales. Para estudiar el sistema reproductivo y sexual se efectuaron experiencias en una población de La Viña, (Salta, Argentina) en 2017 y 2018. Se detallaron varios aspectos macro y micro-morfológicos. El mayor éxito reproductivo ocurrió con polinización libre aunque con valores bajos; la relación polen/óvulo indicó autoincompatibilidad y xenogamia obligada. Los individuos son dioicos y polígamo-monoicos. Las áreas en que las poblaciones se encuentran están amenazadas y en ellas actúa como una especie pionera colonizadora de sustratos rocosos calcáreos erosionados e inestables donde desarrolla un importante rol en la protección ambiental.
Editorial
Authors: Abrahão de los Santos Eduarda Kali , De Moraes Bueno Bernardo José
Published: July 2020

Editorial da edição v6n1.
SETTLEMENT MONITORING OF THE EARTH DAMS BY PERFORMANCE PERIODICAL TOPO-GEODETIC MEASUREMENTS
Authors: Agapie (Mereuta) Ioana , Luca Mihail
Published: July 2020

The paper presents the current way of elaboration of the topographical and cadastral documentation needed in the process of tracking the behavior of hydrotechnical constructions such as earth dam. The studied area is represented by the accumulation of Pârcovaci located in the Deleni territorial administrative unit in Iași county. Using topo-geodetic measurements the magnitude of the vertical displacement of the studied construction were determined. The measurements were performed during the exploitation period of the dam, during 23 series of observations. Thus, there were highlighted the displacements of landmarks located on coping dam, downstream slope and outlet tower. Charts of evolution over time of vertical deformation have been made according to field observation. Also, the suface of the land corresponding to the whole of the accumulation of Pârcovaci was registered at Office of Cadastre and Real Estate Advertising Iași, through first registration documentation. This has made precise spatial delimitation of the set of lands and construction of studied area, and the whole land was recorded in the land book by assigning a unique cadastral number.
First record of Elga leptostyla Ris, 1911 (Odonata, Libellulidae) from Costa Rica
Authors: Román-Heracleo Jareth , Springer Monika
Published: July 2020

During research in the Tirimbina Biological Reserve, on the Caribbean slope of Costa Rica, we captured adult specimens and reared larvae of the dragonfly Elga leptostyla Ris, 1911, which belongs to the Libellulidae. This species was previously reported only from southern Panama to northern South America. Therefore, this is the first record of the species and genus from Costa Rica, increasing the number of Libellulidae species recorded in the country to 95. This species’ known distribution is northwards.
A Case of Metastatic Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome-Associated Renal Cell Carcinoma Treated with a Sequence of Axitinib and Nivolumab Following Cytoreductive Nephrectomy
Authors: Yonese Ichiro , Ito Masaya , Takemura Kosuke , Kamai Takao , Koga Fumitaka
Published: July 2020

Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) associated renal cell carcinoma (RCC) is an aggressive form of type 2 papillary RCC caused by deficiency of the fumarate hydratase gene. For patients with metastatic disease, no standard treatment has been established with dismal prognosis. We report a case of metastatic HLRCC-associated RCC in a 65-year-old Japanese male whose clinical features mimicked advanced renal pelvic cancer. A durable response was achieved with a sequence of axitinib and nivolumab after cytoreductive and diagnostic nephrectomy. Their potential therapeutic roles in the management of metastatic HLRCC-associated RCC have been discussed based on its molecular and biological backgrounds.