bluuebunny/crossref_metadata_2025 huggingface dataset:
Ciência para todos?
Authors: Rumjanek Vivian , Da-Silva Wagner Seixas
Published: February 2020

O presente trabalho discute o atual conhecimento e interesse do jovem pela ciência, apresenta uma experiência metodológica de ensino bem sucedida por mais de três décadas, que pôde ser expandida para diferentes estados, com grande impacto social, envolvendo parcerias universidade-escola. Essa metodologia foi capaz de ser adaptada para um público surdo conhecido por sua dificuldade em se interessar e compreender a ciência. Afeta também os graduandos e pós-graduandos nas universidades envolvidas sensibilizando-os para a realidade brasileira.
Feiras de ciência, a revolução científica na escola
Authors: Pavão Antonio Carlos , Lima Maria Edite Costa
Published: February 2020

A Feira de Ciência é um evento marcante na vida do estudante e um atraente espaço de divulgação científica, mas também é um forte indutor de atividades autônomas de pesquisa científica e tecnológica. Integra e anima alunos, professores e famílias, promovendo uma educação para a ciência onde a apropriação do conhecimento ocorre através da investigação científica em busca de soluções para problemas do cotidiano ou de interesse mais geral.
Construction of Carbon-Carbon and Carbon-Heteroatom Bonds: Enabled by Visible Light
Authors: Mondal Animesh , Mukhopadhyay Chhanda
Published: February 2020

The present review provides an overview of visible light-mediated environment-
friendly approaches over the past decade for the formation of carbon-carbon and
carbon-heteroatom framework. This area has recently emerged as a versatile, environmentally
benign and green platform for the development of a highly sustainable synthetic
methodology. According to the recent advancements, visible light has come to the forefront
in synthetic organic chemistry as a powerful green strategy for the activation of small
molecules.
WITMSG: Large-scale Prediction of Human Intronic m6A RNA Methylation Sites from Sequence and Genomic Features
Authors: Liu Lian , Lei Xiujuan , Meng Jia , Wei Zhen
Published: February 2020

Introduction:

N6-methyladenosine (m6A) is one of the most widely studied epigenetic modifications.
It plays important roles in various biological processes, such as splicing, RNA localization
and degradation, many of which are related to the functions of introns. Although a number of computational
approaches have been proposed to predict the m6A sites in different species, none of them
were optimized for intronic m6A sites. As existing experimental data overwhelmingly relied on polyA
selection in sample preparation and the intronic RNAs are usually underrepresented in the captured
RNA library, the accuracy of general m6A sites prediction approaches is limited for intronic m6A sites
prediction task.

Methodology:

A computational framework, WITMSG, dedicated to the large-scale prediction of intronic
m6A RNA methylation sites in humans has been proposed here for the first time. Based on the
random forest algorithm and using only known intronic m6A sites as the training data, WITMSG takes
advantage of both conventional sequence features and a variety of genomic characteristics for improved
prediction performance of intron-specific m6A sites.

Results and Conclusion:

It has been observed that WITMSG outperformed competing approaches
(trained with all the m6A sites or intronic m6A sites only) in 10-fold cross-validation (AUC: 0.940)
and when tested on independent datasets (AUC: 0.946). WITMSG was also applied intronome-wide in
humans to predict all possible intronic m6A sites, and the prediction results are freely accessible at
http://rnamd.com/intron/.
Cholesterol-Conjugate as a New Strategy to Improve the Cytotoxic Effect of 5-Fluorouracil on Liver Cancer: Impact of Liposomal Composition
Authors: Alanazi Saleh Ayed , Harisa Gamaleldin Ibrahim , Badran Mohammad M. , Haq Nazrul , Radwan Awwad Abdoh , Kumar Ashok , Shakeel Faiyaz , Alanazi Fars Kaed
Published: February 2020

Purpose:

Hepatocellular carcinoma (HCC) is a common liver malignancy, which has a low
survival rate of all cancers. 5-fluorouracil (5-FU) is clinically recognized to treat HCC. However, the
success of this therapy is highly limited due to rapid clearance and non- selective distribution. Cholesterol-
conjugate (5-FUC) loaded liposomes proposed to facilitate the transport of 5-FUC into tumor cells
via Low-Density Lipoprotein receptor (LDL receptor) that overexpressed in HCC. Thus, the aim of this
study was to use 5-FUC loaded liposome as a promising strategy to combat HCC and improve the response
of HCC to chemotherapy.

Methods:

5-FUC and 5-FU loaded liposomes were optimized based on Cholesterol (CHO) ratio and
type of phospholipid to achieve a potential effect on HCC. Liposomes were prepared by the thin-film
hydration method, and evaluated in terms of particle size, polydispersity, zeta potential, Entrapment
Efficiency (EE), morphology, drug release and cytotoxicity.

Results:

The obtained liposomes had a suitable nano-range particle size with negative zeta potential,
and acceptable EE%. In vitro drug release of 5-FUC loaded liposomes showed a lower cumulative release
over 24 h as compared to 5-FU loaded liposomes. 5-FUC loaded liposomes exhibited a higher in
vitro cytotoxic effect as compared to the free drug and 5-FU loaded liposomes against HepG2 cell lines
after 48 h via MTT assay.

Conclusion:

These results concluded that 5-FUC loaded liposomes could be used as an alternative tactic
to increase the therapeutic index of 5-FU and pave the way for potential clinical applications.
The Impact of Sarcopenic Obesity on Health-Related Quality of Life of Treatment-Seeking Patients with Obesity
Authors: Itani Leila , Kreidieh Dima , El Masri Dana , Tannir Hana , El Ghoch Marwan
Published: February 2020

Background:

There is a paucity of studies on health-related quality of life (HRQoL) and sarcopenic obesity (SO).

Objective:

This study aimed to assess the potential association between SO and impaired HRQoL.

Methods:

The ORWELL 97 questionnaire was used to assess HRQoL and body composition was measured using a bioimpedance analyser (Tanita BC-418) in 130 patients with obesity, referred to the Nutritional and Weight Management outpatient clinic of Beirut Arab University in Lebanon. Participants were then categorized on the basis of the absence or presence of SO.

Results:

Sixty-four of the 130 participants met the criteria for SO (49.2%) and displayed significantly higher total ORWELL 97 scores than those in the group without SO (64.00 vs. 41.00, p=0.001), indicative of poorer HRQoL. Linear regression analysis showed that SO was associated with an increase in ORWELL 97 scores by nearly 24 units (β=24.35, 95% CI=11.45-37.26; p<0.0001). Moreover, the logistic regression analysis showed that SO increased the odds of clinically significant impairment of HRQoL (ORWELL 97 score ≥74.25) by nearly seven-fold (OR=7.37, 95% CI=1.92-28.39; p=0.004).

Conclusion:

Our findings show that the presence of SO was associated with increased impairment of HRQoL that reaches clinical significance when compared to obesity only. Future studies are needed to clarify whether this may influence clinical outcomes. If this is shown to be the case, weight management programs should incorporate additional strategies to improve HRQoL in individuals with SO.
Electrochemical Biosensor for the Detection of Amygdalin in Apple Seeds with a Hybrid of f-MWCNTs/CoFe2O4 Nanocomposite
Authors: Inamuddin  , Kanchi Suvardhan , Kashmery Heba A.
Published: February 2020

Background:

Amygdalin is a natural compound known for curing cancer. It is seen in
several plants including in bitter almonds, apricots, peaches, apples, and plum seeds (kernels).
Amygdalin is a toxic molecule containing a nitrile group, due to which toxic cyanide anion releases
by the action of a β-glucosidase. The consumption of amygdalin may lead to cyanide poisoning in
the human body. Therefore, for the first time, this work is aimed at developing a novel electrochemical
biosensor for the detection of Amygdalin (AMG) in apple seed samples.

Methods:

The proposed electrochemical biosensor was fabricated by immobilizing cytochrome c
(Cyt c) on a Glassy Carbon Electrode (GCE) with nanocomposite of cobalt ferrite nanoparticles
(CoFe2O4 NPs) and functionalised multiwalled carbon nanotubes (f-MWCNTs). The characterization
of the synthesized nanocomposite was performed with FTIR, TEM, TGA/DSC, and XRD techniques.
Moreover, various experimental parameters such as the effect of pH, deposition time, sweep rate, potential,
and enzyme incubation time and interference were also studied.

Results:

The fabricated biosensor enhanced the peak current by 10-folds compared to unmodified
GCE. Under optimized experimental conditions, the biosensor exhibited linear response from 2 to 20
μM, with a linear regression equation Ipa (μA) = 8.4989 c + 6.6307 (R² = 0.9927). The LOD’s and
LOQ’s were found to be 0.0112 μM and 0.2213 μM, respectively.

Conclusion:

The designed biosensor was successfully applied for the analysis of AMG content in the
apple seed samples. The outcomes of this study identify the efficient electrocatalytic activity of the
fabricated nanocomposite as significant electronic factors as major contributors to the electron transfer
mechanism, with promising scope for the design of biosensor to sense toxic molecules.
Functional and Structural Characterization of a Novel Isoamylase from Ostreococcus tauri and Role of the N-Terminal Domain
Authors: Hedín Nicolas , Barchiesi Julieta , Gomez-Casati Diego F. , Busi María V.
Published: February 2020

Background:

The debranching starch enzymes, isoamylase 1 and 2 are well-conserved enzymes present in almost all the photosynthetic organisms. These enzymes are involved in the crystallization process of starch and are key components which remove misplaced α-1,6 ramifications on the final molecule.

Aim:

In this work, we performed a functional and structural study of a novel isoamylase from Ostreococcus tauri.

Methods:

We identified conserved amino acid residues possibly involved in catalysis. We also identified a region at the N-terminal end that resembles a Carbohydrate Binding Domain (CBM), which is more related to the family CBM48, but has no spatial conservation of the residues involved in carbohydrate binding.

Results:

The cloning, expression and biochemical characterization of this N-terminal region confirmed that it binds to polysaccharides, showing greater capacity for binding to amylopectin rather than total starch or amylose.

Conclusion:

This module could be a variant of the CBM48 family or it could be classified within a new CBM family.
Lemon Peel Powder: A Natural Catalyst for Multicomponent Synthesis of Coumarin Derivatives
Authors: Jadhav Ganesh D. , Mujawar Taufique Ahmed P. , Tekale Sunil U. , Pawar Rajendra P. , More Yogesh W.
Published: February 2020

Background:

Lemon peel powder was used as a natural catalyst for the synthesis of biscoumarins
and 3,4-dihydropyrano[c]chromene derivatives. The catalyst is natural, biodegradable, environmentally
benign and thus contributes a valuable addition to the existing sustainable methods for the
synthesis of coumarin derivatives.

Objective:

Development of Green synthesis and use of Natural catalyst.

Methods:

Lemon peel powder was used as a natural, biodegradable, environmentally benign heterogenous
catalyst for the synthesis of coumarin derivatives.

Results:

Natural lemon peel powder was successfully used as a heterogeneous catalyst for the synthesis
of coumarin based heterocyclic compounds.

Conclusion:

In conclusion, an environmentally benign, green and one-pot multicomponent protocol
has been developed for the synthesis of biscoumarins and 3,4-dihydropyrano[c]chromene derivatives
using lemon peel powder as a natural and biodegradable catalyst. Lemon peel being natural, the present
approach is sustainable and will highlight the emerging applications of natural resources for synthetic
organic transformations. This protocol offers several advantages such as high yields, clean reaction
conditions, and no pollution threat to the environment making it a useful and attractive process for the
synthesis of coumarin derivatives.
Antioxidant Profile of Home Prepared Taraxacum Officinale Weber Ex Wigg Beverage
Authors: Kontogiorgis Christos , Deligiannidou Georgia Eirini , Karamani Vasiliki , Hadjipavlou-Litina Dimitra , Lazari Diamanto , Papadopoulos Athanasios
Published: February 2020

Background:

Aromatic plants are quite popular for daily use worldwide. However, little
is known about the appropriate preparation of beverages in “house conditions” in order to preserve
their beneficial characteristics after processing. Taraxacum officinale Weber ex Wigg contains a
variety of compounds, with well-documented effects against oxidative stress. This study aims to
investigate the optimum preparation conditions of a Taraxacum beverage in the household setting,
with respect to its antioxidant characteristics.

Methods:

Dried, commercial T. officinale was used to prepare beverages boiling for 1, 3 or 5 min.
The beverages were extracted using organic solvents of increasing polarity, and the solid residues
of each extraction were examined by in vitro analysis on: the evaluation of total phenolic content
(Folin Ciocalteau), the evaluation of antioxidant activity (DPPH and ABTS radicals scavenging),
the evaluation of the ability of the tested extracts to compete with DMSO for OH radicals, the
ability to inhibit lipid peroxidation of linoleic acid and soybean lipoxygenase inhibition assay.

Results:

All preparations had an overall good antioxidant profile. Regarding the chosen solvents,
mid polarity solvents were more likely to give better results in all tests conducted, which can be
indicative of the compounds extracted in each fraction. Samples prepared under 3 min boiling
presented significant interaction with DPPH and strong lipoxygenase and lipid peroxidation
inhibition.

Conclusion:

As previously observed in the literature, food processing can greatly affect its
biochemical characteristics. In the case of Taraxacum, boiling for 3 min resulted in the best overall
profile of the beverage with respect to its antioxidant properties. However, due to a variety of
components present in each plant, further investigation and stratification, along with in vivo
experiments are needed.
Penanganan kasus bidang politik dalam pembelajaran Pendidikan Kewarganegaraan
Authors: Nasiwan Nasiwan
Published: February 2020

The teaching of Civic Education in Indonesia, especially on politics, from the perspire if its content is the most dynamic element in comparison to moral rapid change due to reformation undergone in Indonesia since May, 20 1998 or often is called as transitional democracy. In the period of transitional democracy since that time up to the end of 2006, many aspects of political affair has been changing radically both in super structures and in infrastruc­tures politic. As a result, the teaching of civic education, especially on politic as its materials, needs of handling of political cases accurately. The goal is to avoid misconception; its ap­proaches, as well as its methods of teaching.
DEVELOPMENT AND VALIDATION OF NOVEL REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF ANDROGRAPHOLIDE AND ALOE-EMODIN
Authors: PATIL RASHMI , JAISWAR UTTARA , JAIN VANDANA
Published: February 2020

Objective: The study aims to develop and validate a novel reverse-phase high-performance liquid chromatographic method for simultaneous estimation of andrographolide and aloe-emodin in herbal formulation and validate as per the International Conference on Harmonization (ICH) guidelines.

Methods: The analysis was carried on a Shimadzu LC Prominence-i 2030 model with the Lab Solution software. The column used for separation was Prontosil C18 (250×4.6 mm, 5 μ), with a mobile phase consisting of acetonitrile and 0.05% orthophosphoric acid (45:55), at a flow rate of 1 ml/min, column temperature was maintained at 28°C and effluents were monitored at 225 nm. The injection volume was 10 μl.

Results: The retention time of andrographolide and aloe-emodin was found to be 4.57±0.2 min and 12.29±0.2 min, respectively. The markers were resolved using linear responses that were obtained in concentration ranges of 0.5–60 μg/ml with correlation coefficient (r2) of 0.9992 and 0.999 for andrographolide and aloe-emodin, respectively. The precision results were found to be satisfactory, which indicates that the method is precise. The recovery values lie in the range of 98–120% indicating the accuracy of the method.

Conclusion: A novel, simple, accurate, precise, and robust reverse-phase high-performance liquid chromatography method was developed for the simultaneous estimation of andrographolide and aloe-emodin. The developed method can be used for analysis of the formulations containing these phytoconstituents.
RESEARCH OF LEGAL REGULATION OF PERSONNEL SAFETY OF THE PHARMACEUTICAL ORGANIZATIONS IN RUSSIA
Authors: A KUZNETSOV DMITRY , U KLISСHENKO MARINA
Published: February 2020

Objective: The study consists in the analysis of the main regulatory acts governing personnel safety in pharmaceutical organizations. In the process of managing a pharmaceutical organization, the leader must rely on the requirements of current legislation in the field of personnel safety. Safety is the main strategic activity of any pharmaceutical organization. The legal framework governing personnel security is constantly expanding. Actually study the fundamental standards of personnel safety.

Methods: The methods of analysis were a systematic approach, logical grouping, content analysis of the main documents regulating personnel security in the pharmaceutical industry.

Results: The fundamental regulatory acts were identified that play a major role in ensuring and regulating the personnel safety of pharmaceutical organizations. Personnel security is a key element of the economic security of a pharmaceutical organization. The management of pharmaceutical personnel in the personnel safety system consists in finding ways to minimize risks and threats from and in relation to employees. The basic regulatory acts in the system of personnel security are identified, which allow to level threats and optimize the sustainable development of the pharmaceutical organization.

Conclusion: In Russia, the legal basis for the personnel security of pharmaceutical organizations is: the Constitution; international treaties; federal constitutional laws; federal laws and regulations; Government Decisions; laws and other regulatory legal acts of entities. The term “security” is introduced by the law “On Security”. The main security threats are identified in the Economic Security Strategy for the period until 2030.
RELAÇÃO DA HALITOSE COM AS DOENÇAS GENGIVAIS E SUA INTERFERÊNCIA NA QUALIDADE DE VIDA DOS PACIENTES ATENDIDOS NO CENTRO ODONTOLÓGICO DE UMA INSTITUIÇÃO DE ENSINO SUPERIOR NO MUNICÍPIO DE PORTO VELHO-RO
Authors: Santos Patricia Chaves dos , Guimarães Gustav , Cintra Luciano Ângelo Tavares , Silva Cristiane Cantiga da , Guimarães Maria Rosa Félix de Souza Gomide
Published: February 2020

A halitose é um problema frequente na população em geral. Grande parcela dos indivíduos apresenta alguma forma de mau odor oral de maneira crônica com potenciais consequências sérias na vida pessoal e profissional. O presente estudo teve como objetivo avaliar a presença e interferência da halitose na qualidade de vida dos pacientes atendidos na clínica odontológico do Centro Universitário São Lucas, do município de Porto Velho-RO, além de realizar um levantamento buscando relacionar sua incidência a doenças sistêmicas presentes nessa amostra. Tendo como base uma população de 250 pessoas, foi avaliada uma amostra de 171 pacientes, que concordaram em responder o questionário estruturado, e em seguida realizar o teste de halimetria e avaliação de presença ou não de saburra lingual. Foram analisados, através do prontuário de cada paciente, o exame periodontal e antecedentes pessoais médicos e odontológicos. A idade média dos pacientes avaliados é de 34,4 anos do total da amostra. 27,5% apresentaram odor pesado; 43,9 apresentaram gengivite; 31% tinham periodontite, 56,7% acreditam ter mau hálito, sendo que 29,6% relataram algum tipo de prejuízo na sua vida social. Portanto a partir dos resultados obtidos pode verificar que existe uma forte relação da halitose com doenças bucais, comprometendo a convivência social desses pacientes.
Centaurium erythraea extract reduces redox imbalance and improves insulin expression and secretion in pancreatic β-cells exposed to oxidative and nitrosative stress
Authors: Djordjevic Milos , Grdovic Nevena , Mihailovic Mirjana , Arambasic-Jovanovic Jelena , Uskokovic Aleksandra , Rajic Jovana , Djordjevic Marija , Tolic Anja , Misic Danijela , Siler Branislav , Poznanovic Goran , Vidakovic Melita , Dinic Svetlana
Published: February 2020

Oxidative stress is one of the major mechanisms that underlies the damage of pancreatic ?-cells and defects in insulin secretion in diabetes. As herbal preparations can alleviate oxidative stress through their redox-active secondary metabolites, in this study we investigated the cytoprotective effects of Centaurium erythraea extract (CEe) against H2O2- and SNP-induced oxidative/nitrosative stress in Rin-5F ?-cells. The antioxidant activity of CEe and its effect on cell survival and insulin expression/secretion were evaluated. The CEe increased cell viability and ameliorated the disturbance of redox homeostasis in H2O2- and SNP-treated cells by decreasing DNA damage, lipid peroxidation and protein S-glutathionylation. The CEe restored GSH homeostasis in H2O2-treated ?-cells and attenuated the SNP-induced disturbance of the GSH/ GSSG ratio. The H2O2- and SNP-induced disruption of CAT, GPx, GR, MnSOD and CuZnSOD activities was adjusted by the CEe towards control values, as well as mRNA and protein levels of GPx, MnSOD and CAT. The CEe increased insulin expression/secretion particularly in H2O2-treated ?-cells, which was in accordance with the more pronounced antioxidant effect of the CEe observed in H2O2-treated ?-cells as compared to SNP-treated cells. These findings support the beneficial effect of the CEe in preventing or slowing down ?-cell damage and dysfunction caused by oxidative/nitrosative stress during diabetes development.
A system to monitor and model the thermal isolation of coating compounds applied to closed spaces
Authors: Florez Montes , Fernández de , Higón Calvet , Conejero Alberto , Poza-Luján José-Luis
Published: February 2020

Smart control systems and new technologies are necessary to reduce the energy consumption in buildings while achieving thermal comfort. In this work, we monitor the thermal evolution inside a scale reduced closed space whose exterior and/ or interior wall faces have been painted with a coating solution. Based on the experimental data obtained under different environmental conditions, a simulator was developed and tuned to reproduce the thermodynamic behavior inside the spaces, with a relative error of less than 3.5%. This simulator lets us also estimate energy savings, temperature, and flux behavior under other conditions.
Design and thermal analysis of a novel permanent magnet-friction integrated brake for vehicle
Authors: Wang Kuiyang , He Ren , Tang Jinhua , Liu Ruochen
Published: February 2020

This article focuses on a new type of permanent magnet-friction integrated brake. The design scheme of integrated brake is proposed. Taking the maximization of braking moment and the minimization of volume as the dual optimization objectives, the particle swarm optimization algorithm is used to optimize the integrated brake, and the main structure parameters of the integrated brake are obtained. Based on the obtained structure parameters, the 3-D model of integrated brake is established. The mathematical models of electromagnetic field and temperature field of integrated brake are given, respectively. Taking a typical braking process as an example, the magnetic field of integrated brake is analyzed based on COMSOL software, which verifies the correctness of the design model of permanent magnet brake. The eddy current loss in the magnetic field of permanent magnet brake and the thermal contact of friction brake are taken as heat sources of the integrated brake, then the temperature field of integrated brake is analyzed. The analysis results show that the integrated brake meets the requirements of braking performances, and improves the heat recession resistance compared with the traditional friction brake.
Diffusion Welding of Al-α-Si3N4 Composite Materials
Authors: ARIK Halil , ERDEN İbrahim Okan , AYDIN Mustafa
Published: February 2020

ABSTRACT

In this study, Al-a-Si3N4
composite, produced by powder metallurgy method, were joined at 2.5 MPa
pressure with various welding temperatures (620, 630, and 640 °C ) and
durations (1,1.5, and 2 h.) by diffusion welding method. Optical microscopy
examination was carried out from welded interfaces and shear tests were also conducted
to the sample interfaces to find out the effect of welding parameters and
amount of α-Si3N4 reinforcement on
the weldability properties of composite materials. The test results show that
increase in the welding temperature and duration resulted in increase shear
resistance of the welded zone. Results indicated that optimum parameters
(welding temperatures, durations and amount of α-Si3N4
are 640°C, 2 h., and 15wt % respectively) MMCs produced in this study could be
joined by diffusion welding technique successfully with the 97.5 % strength of
base material.
Çerçeve Sistemlerin Yapı Zemin Etkileşimli Serbest Titreşim Analizi
Authors: KARA Döndü , BOZDOĞAN Kanaat Burak , KESKİN Erdinç
Published: February 2020

Bu çalışmada, düzlem çerçevelerin periyotlarındaki değişim yapı zemin etkileşimi dikkate alınarak incelenmiştir. Bu amaçla Türkiye Bina Deprem Yönetmeliği’nde yer alan zemin sınıflarını temsil eden 5 farklı zemin sınıfı dikkate alınmıştır. Çalışmada basitleştirilmiş yöntemlerin bu tür sistemlerin serbest titreşim analizinde kullanılmasının uygunluğu araştırılmıştır. Tipik bir çerçeve sistemin serbest titreşim analizi beş farklı zemin sınıfı için dört farklı yaklaşımla yapılarak sonuçlar karşılaştırılmıştır. Birinci modelde SAP2000 yazılımı kullanılarak zemin kabuk elemanlarla modellenmiştir. İkinci modelde gene SAP2000 kullanılmış ancak zemin eşdeğer kolonlarla temsil edilmiştir. Üçüncü modelde ise çerçeve sistem ile zemin eşdeğer kayma kirişi yaklaşımı ile modellenmiştir. Bu modele ait yatay rijitlik matrisleri ve kütle matrisleri SCILAB paket programı yardımıyla oluşturularak periyotlar elde edilmiştir. Dördüncü model ise yapı ve zeminin yapı yüksekliği ve zemin tabakaları boyunca üniform olduğu kabulüne dayanmaktadır. Dördüncü modelde literatürde yer alan pratik bir bağıntı çalışmada ele alınan örneğe uygulanarak doğal titreşim periyotları farklı beş zemin sınıfı için elde edilmiştir. Çalışmanın sonunda elde edilen sonuçlar değerlendirilmiştir.
Does herding exist in lottery stocks? Evidence from the Indian stock market
Authors: Ansari Aleem , Aziz Tariq , Ansari Valeed Ahmad
Published: February 2020

In this paper, we investigate the presence of herd behaviour among lottery stocks using Max, skewness and idiosyncratic volatility in the Indian stock market during the period January 2000 to December 2018. We demonstrate that the herd behaviour is non-existent across proxies of lottery-stocks MAX and skewness and find that the herd behaviour is present among highly idiosyncratic stocks. This sheds light on why herding is not detected in the prior studies as it may be concentrated among stocks with certain characteristics. Further, it provides evidence of adverse herding.
Las implicancias del BREXIT en Europa y en el mundo
Authors: Pérsico Juan Carlos , Consani Norberto
Published: February 2020

Se analiza la trascendencia del Brexit que significa la salida por propia voluntad de Gran Bretaña del bloque regional y los múltiples efectos no sólo en este país sino también en la Unión Europea en su conjunto, y en el mundo y los grandes desafíos que afectan su composición territorial actual, sus partidos políticos tradicionales, su economía y comercio, y el bienestar general de sus ciudadanos, en una sociedad que ha quedado profundamente dividida.

Del mismo modo, tambien como el proceso afectaria a la Unión Europea por perder a la quinta economía mundial (y segunda en el bloque regional),  y a una de las principales potencias militares del planeta, y la preocupacion por contener el efecto contagio del Brexit en sus países miembros en los que se observa con gran preocupación el crecimiento constante de movimientos políticos nacionalistas populistas contrarios al proceso de integración regional europeo.
Synthesis, antibacterial and free radical scavenging activity of some newer N-((10-nitro-1H-indolo [1, 2-c]quinazolin-12-yl)methylene)benzenamines
Authors: Dixit A. , Pathak D. , Sharma G.K.
Published: February 2020

Present research is oriented on the synthesis of some novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazoline analogs (4b1-4b11) and their characterization by 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Their free radical scavenging activity and antibacterial potential were also evaluated. Many derivatives have shown a marked free radical scavenging capacity in all the concentrations but specifically compounds 4b7, 4b8 and 4b11 have shown good antioxidant potential with an IC50 value of 25.18 μmol/L, 28.09 μmol/L ---amp--- 44.22 μmol/L, respectively (DPPH method) and 39.46 μmol/L, 44.47 μmol/L ---amp--- 35.61 μmol/L, respectively (H2O2 method). The antibacterial evaluation was carried out against B. subtilis and E. coli by agar well diffusion method and it revealed that all the compounds in the series were having marked antibacterial activity but compounds 4b9 and 4b11 have shown best antibacterial potential. Then, it was concluded that the derivatives which were containing substituted anilines (4-Nitro, 4-Fluoro, 4-Bromo ---amp--- 4-Chloro-2-nitro) on the carbon attached on the 12th position of indoloquinazoline moiety were having marked potential as an antibacterial and free radical scavenger.
Investigation of Textile Heating Element in Simulated Wearing Conditions
Authors: Stygienė Laimutė , Varnaitė-Žuravliova Sandra , Abraitienė Aušra , Padleckienė Ingrida , Krauledas Sigitas
Published: February 2020

The research was focused on the heating capacity of developed, isolated from water penetration, knitted textile heating element with incorporated conductive silver (Ag)- plated yarns, which can be used in manufacturing heating textile products intended for recreation, sports, or health care for elderly. The aim of the investigation was to obtain an appropriate temperature on a human skin, generated by the textile heating element surface at a lower voltage depending on a variety of wearing conditions indoor. Depending on the supplied voltage to the heating element, an incoming electric energy can be converted into different heat. Therefore, the electrical and achieved temperature parameters of heating elements are very important by selecting and adapting required power source devices and by setting the logical parameters of programmable controllers. The heating–cooling dynamic process of developed textile heating element was investigated at different simulated wearing conditions on a standard sweating hot plate and on a human skin at applied voltages of 3V and 5V. It was discovered that a voltage of 5 V is too big for textile heating elements, because the reached steady state temperature increases to approximately 39–40°C, which is too hot for contact with the human skin. The voltage of 3 V is the most suitable to work properly and continuously, i.e., to switch on when the adjusted temperature is too low and to turn off when the necessary temperature is reached. Based on the values of reached steady-state heating temperature, the influence of the applied voltage, ambient air flow velocity, and heating efficiency, depending on various layering of clothes, was determined. Recorded temperatures on the external surface of the heating element provided the possibility to assess its heat loss outgoing into the environment. It was suggested that heat loss can be reduced by increasing thermal insulation properties of the outer layer of the heating element or using layered clothing. On the basis of the resulted heating characteristics, recommended parameters of power source necessary for wearable textile heating element were defined.
Understanding Player Load: Meanings and Limitations
Authors: Bredt Sarah da Glória Teles , Chagas Mauro Heleno , Peixoto Gustavo Henrique , Menzel Hans Joachim , Andrade André Gustavo Pereira de
Published: February 2020

We present a critical reflection on the mechanical variable Player Load, which is based on acceleration data and commonly used in sports. Our motivation to write this paper came from the difficulties that we encountered in the calculation and interpretation of Player Load using our own data, since we did not use the Catapult Sports equipment, which is a merchandise of the company that proposed this variable. We reviewed existing literature in order to understand Player Load better; we found many inconsistencies in PL calculation methods and in the meanings attached to it. Accordingly, this paper presents a brief discussion on the meanings that have been assigned to Player Load, its limitations, and the lack of clear and complete information about Player Load calculation methods. Moreover, the use of arbitrary units and different practical meanings in the literature has associated Player Load with many physical quantities, thereby resulting in difficulties in determining what Player Load measures within the context of sports. It seems that Player Load is related to the magnitude of changes in acceleration, but not the magnitude of acceleration itself. Therefore, coaches and sports scientists should take this information into account when they use Player Load to prescribe and monitor external loads. We concluded that a deeper discussion of Player Load as a descriptor of external load is warranted in the sports sciences literature.
Eating Habits and Body Composition of International Elite Soccer Referees
Authors: Mascherini Gabriele , Petri Cristian , Ermini Elena , Pizzi Angelo , Ventura Antonio , Galanti Giorgio
Published: February 2020

Soccer referees are a specific group of the athletes’ population whose careers peak from 30 to 45 years old. An athlete's performance is not only determined by physical training but also by a lifestyle, e.g. eating habits. The purpose of this study was to verify current eating habits and resulting body composition of a group of elite international soccer referees. At an international FIFA seminar 60 elite international soccer referees (aged 39.2 ± 4.2 years) were enrolled. A body composition assessment was performed with skinfold thickness and bio impedance analysis, while eating habits were evaluated with a multi-pass 24-hour dietary recall. The body composition showed a normal weight condition with a fat content of 11.4 ± 2.5%. Macronutrients showed a low level of carbohydrates (43.6 ± 5.4%) and a high level of fat (40.0 ± 4.5%). Micronutrients showed a low level of calcium, potassium, zinc, magnesium, iodine, vitamin B12 and vitamin B9. Even though their body composition was within the normal range, the current eating habits of elite international soccer referees did not appear to follow the nutrition guidelines. Therefore, it would be advisable to provide knowledge on nutrition for this particular category of sports subjects, an individualized nutritional plan would be advisable, in order to achieve and maintain better performance and appropriate body composition for their role.
Taekwondo Anaerobic Intermittent Kick Test: Discriminant Validity and an Update with the Gold-Standard Wingate Test
Authors: Tayech Amel , Mejri Mohamed Arbi , Chaouachi Mehdi , Chaabene Helmi , Hambli Mourad , Brughelli Matt , Behm David G. , Chaouachi Anis
Published: February 2020

The aim of this study was to update the validity of the Taekwondo Anaerobic Intermittent Kick Test compared with the 30-s Wingate anaerobic test as the "Gold-Standard", squat jump and countermovement jump tests. The second objective was to examine whether this new specific test would be able to effectively discriminate between elite taekwondo athletes of different competitive levels. Twenty taekwondo athletes (15 males and 5 females) participated in the validation component, whereas 18 (14 males and 4 females) and 16 (13 males and 3 females) athletes participated in the reliability analysis of the Wingate anaerobic test and jumping tests, respectively. They performed these tests on two separate occasions (i.e., test-retest), in addition to the Taekwondo Anaerobic Intermittent Kick Test. To establish test’s discriminatory capability (i.e., construct validity), two subgroups were identified based on their international and national taekwondo performance: 10 elite (8 males and 2 females) and 9 sub-elite (7 males and 2 females) athletes. Wingate anaerobic test and jumping tests performances showed excellent reliability (ICC > 0.90, SEM < 5% for most variables). Significant correlations between Taekwondo Anaerobic Intermittent Kick Test, Wingate anaerobic test, and jumping tests’ variables were mostly "large". Elite taekwondo athletes showed greater taekwondo test performances compared with their sub-elite counterparts (p < 0.001). Receiving operating characteristic analysis indicated that the taekwondo specific test was able to effectively discriminate between elite and sub-elite taekwondo athletes. Overall, the findings of the current study support the concurrent validity of the Taekwondo Anaerobic Intermittent Kick Test. In particular, the Taekwondo Anaerobic Intermittent Kick Test showed good ability to effectively discriminate between taekwondo athletes of different competitive levels.
Spanish Elite Soccer Reserve Team Configuration and the Impact of Physical Fitness Performance
Authors: Arcos Asier Los , Martínez-Santos Raúl , Castillo Daniel
Published: February 2020

The aim of this study was threefold: 1) to assess the configuration of an elite reserve soccer team, 2) to compare physical fitness performance of promoted and new players according to the playing position, and 3) to analyze the level of competitive participation attained by these players. We considered physical fitness tests (5 m and 15 m sprint, countermovement jump [CMJ] and aerobic endurance) performed by 192 players (age = 20.2 ± 2.3 years) enrolled in the reserve team of a Spanish La Liga club from 1994 to 2013. The players were classified according to the previous club criterion (promoted from the soccer academy and new players signed from other clubs), b) their playing position, and c) the competitive level attained until the 2016/2017 season (Spanish 1st and 2nd Divisions and the remaining competition levels). The proportion of promoted and new players was similar (p = 0.47). Overall, no substantial differences (unclear-small) were found in physical fitness performance between promoted and new players. Considering the playing position, promoted lateral defenders (LDs) showed better sprinting (ES = moderate) and CMJ (ES = moderate) performance than new LDs. In addition, promoted central midfielders (CMs) demonstrated better performance in the 5 m sprint and the CMJ (ES = moderate) than new CMs. The percentage of players who later competed in the Spanish 1st and 2nd Divisions was greater in promoted players compared to new players (p = 0.006). Physical fitness performance did not determine the selection of new players in a soccer elite reserve team. We may conclude that soccer academies should prioritize the selection and the training process of youth soccer players.
The Use of Small-Sided Games as an Aerobic Fitness Assessment Supplement within Elite Level Professional Soccer
Authors: Owen Adam Lee , Newton Matthew , Shovlin Aidan , Malone Shane
Published: February 2020

The purpose of this investigation was to quantify the association between 5 vs. 5 small sided games (SSG) running performance and physiological performance during the Yo-YoIR1 test to ascertain the utility of SSGs as a potential fitness test modality within elite professional soccer players. Twenty-three (n = 23) elite male professional soccer players (mean ± SD age 25.3 ± 3.1 yrs, mass: 76 ± 9 kg, height: 176 ± 9 cm) were assessed. Players completed an intermittent aerobic fitness test (Yo-YoIR1) and a 5 vs. 5 SSGs protocol for the purpose of the study. During all SSGs players wore GPS (Statsports 10-Hz, Viper Pod, Newry, Northern Ireland) and HR monitors (Polar, Oy Kemple, Finland) with these measures related to Yo-YoIR1 running performance. Results revealed SSGs running performance (TD; m) and physiological performance (HR) showed the lowest CV% (< 5%), with high speed movements, accelerations and decelerations highlighting higher CV% during SSGs. Possibly small to possibly very large associations were observed for running performance during 5 vs. 5 SSGs and Yo-YoIR1 performance, with negative associations observed between physiological performance during SSG and YoYoIR1 running performance. To conclude, the current study observed how running performance during a standardised 5 vs. 5 SSG protocol within elite soccer cohorts is associated with the Yo-YoIR1 running performance. Given the low CV%, repeatability and large association of global running performance and internal load measures during a 5 vs. 5 SSG with Yo-YoIR1 performance, this particular soccer specific SSG protocol potentially supplements traditional non-sport specific testing assessments.
National Energy and Climate Plans: Importance of Synergy
Authors: Zigurs A. , Balodis M. , Ivanova P. , Locmelis K. , Sarma U.
Published: February 2020

In the modern world, including the European Union, the Baltic States and Latvia, the power industry has a broad definition, area and content, several social life and economic existence, comfort and safety provision. It also covers the following segments: heat/thermal energy, transport/fuel, electricity, energy resources and their types, etc.

More competent and wider synergy among different energy sectors and power industry and other areas provides the option to solve the global problems, for example, the mitigation of climate changes and the provision of energy sustainability by reducing the production of greenhouse gases, increasing the use of renewable energy sources, achieving higher energy efficiency and providing the careful use of energy resources. The results of synergy are of economic importance; they provide the efficiency and competitiveness of costs.

In this paper, the necessity of synergy between renewables and conventional generation and synergy among energy sectors are considered to achieve the dimensions of national energy and climate plans.
El devenir de la esfera personal y el panenteísmo en la metafísica tardía de Max Scheler
Authors: Hackett J. Edward
Published: February 2020

En este artículo, explico la visión de Scheler sobre Dios y las personas desde su período fenomenológico inicial y la transición que ocurre en su pensamiento alrededor de 1922 hasta su último trabajo publicado en 1928, El puesto del hombre en el cosmos. En ese trabajo, evalúo las afirmaciones metafísicas sobre el Espíritu y el impulso compenetrantes y me insto a ver la interacción entre ambos como un ejemplo de teísmo dipolar en lugar de la tendencia a interpretar el pensamiento de Scheler como una forma de dualismo. De hecho, muestro que la explicación relacional del proceso de Scheler sobre el Espíritu y el impulso debe leerse a través de la filosofía del organismo de Alfred North Whitehead, aunque no doy a esta posibilidad interpretativa un tratamiento o defensa exhaustivo.
CONTROLE DA ANTRACNOSE EM MAMÃO POR EXTRATOS VEGETAIS
Authors: Siqueira César Luis , Moraes Thais de Castro , Barbedo Martins Jade Ayres , Freire Maria das Graças Machado
Published: February 2020

Para avaliar o efeito de extratos de plantas sobre o crescimento de Colletotrichum gloeosporioides, extratos etanólicos de sementes de pitomba, folhas de tanchagem, boldo e espada-de-são-jorge, foram obtidos e incorporados em meio contendo batata-dextrose-agar (BDA) nas concentrações de 1%, 5% e 10% (v/v). O crescimento micelial do fungo foi avaliado nesse meio. Os resultados demonstraram o efeito inibitório dos extratos de pitomba e tanchagem aumentam consideravelmente em concentrações maiores que 5% (v/v), levando a uma inibição quase total do fungo (90% e 100%, respectivamente). Em contraste, os extratos de boldo e espada-de-são-jorge, apresentaram baixo potencial inibitório mesmo na concentração de 10% (v/v) causando a redução de apenas 8% e 23%, respectivamente, no crescimento fúngico.A atividade fungitóxica detectada nos extratos testados nesse trabalho evidencia o potencial uso dos mesmos como biopreservadores de frutos de mamão, prevenindo a contaminação e a consequente perda dos frutos no período pós-colheita.
ATIVIDADE ENZIMÁTICA E ANTIMICROBIANA DE FUNGOS ENDOFÍTICOS ISOLADOS DE SOJA
Authors: Wenzel Juliana Bernardi , Moresco Adriana Aparecida de Almeida , Boas Edilene Vilas , Burin Flávia Angélica Gonçalvez , De Souza Rodrigo Onofre
Published: February 2020

Devido às potencialidades dos fungos endofíticos como produtores de compostos com atividade antimicrobiana e pela capacidade de produção de enzimas extracelulares, este trabalho teve como objetivo avaliar a atividade antimicrobiana e enzimática de fungos endofíticos isolados de soja. Para avaliação da atividade antimicrobiana, 23 fungos endofíticos foram testados a partir do meio fermentado, acetato de etila e metanol. Foi utilizado o teste de difusão em discos, com ensaios biológicos qualitativos, em triplicata, contra as bactérias patogênicas humanas Escherichia coli, Staphylococcus aureus, Salmonella enterica, Shigella flexneri e Micrococcus luteus.  Em placas de Petri com meio LB contendo as bactérias foram inseridos quatro discos de papel estéreis inoculados com 10 µL de cada extrato metabólito. As placas foram incubadas a 37°C por 24 h. Avaliou-se a atividade antimicrobiana pela formação de halos de inibição. O potencial enzimático foi avaliado para a produção das enzimas extracelulares de proteases, lipases e amilases pela formação de halo de degradação destas em meio mínimo. Quanto à atividade antimicrobiana, 14 isolados apresentaram potencial antibacteriano para pelo menos uma das cinco bactérias patogênicas testadas. Em relação a atividade enzimática 20 isolados apresentaram atividade amilolítica e apenas três proteolítica, não havendo atividade lipolítica para nenhum dos isolados.
SUSTENTABILIDADE NAS CONSTRUÇÕES
Authors: Manhães Gabriela Siqueira , Araújo Ronaldo de Sousa
Published: February 2020

O processo da área da construção civil é bastante heterogêneo, contemplando diferentes âmbitos deorganização produtiva e de formas de comercialização de seus produtos finais, as construções. Nasconstruções, a complexidade e a indispensabilidade de planejamento e gerenciamento são agravadas pelacrescente busca do mercado por maior qualidade em seu desenvolvimento e melhor desempenho do produtofinal. Isso pode não direcionar a comunicação entre os agentes envolvidos e racionalizar a construção e aedificação, mas também mostrar alternativas inteligentes e sustentáveis que respondam à necessidade deminimização dos impactos ambientais. A discussão que envolve os conceitos de construções inteligentes esustentáveis, apesar de ser vista no meio acadêmico, parece ainda não encerrada e engloba os diferentesníveis de organização do indivíduo e daısociedade. O presente estudo tem como objetivo discutir o usodesses conceitos no processo construtivo e em seu resultado final, com a finalidade de identificar possíveisrelações entre os mesmos e as suas contribuições no contexto da sustentabilidade da construção civil.Observou-se que as inovações tecnológicas dispostas nas várias etapas do processo (construção) até oproduto final, geraram soluções sustentáveis que deixam sua contribuição para amenizar os impactos nomeio ambiente. O trabalho contribui para uma reflexão sobre conceitos de sustentabilidade dentro de umavisão mais integral para a arquitetura, abordando o processo e o produto da produção da arquitetura.