bluuebunny/crossref_metadata_2025 huggingface dataset:
Five cases of Peripartum Cardiomyopathy in Malawi
Authors: Matemvu Zaithwa , Likapa Harvey , Makin Mary Sue , Hossain Omar
Published: October 2023

AimThis report of five cases of peripartum cardiomyopathy (PPCM) treated at Daeyang Luke Hospital in Lilongwe, Malawi, illustrates presentation and treatment of this increasingly commonly recognized medical condition.MethodsInformation including history, physical examination, and imaging studies were collected from five cases of peripartum women who presented to the hospital over an 18-month period.ResultsA summary of recommended treatment is included in table form, and a flow chart proposing a care pathway for managing PPCM in Malawi, beginning at the district hospital level, is presented.ConclusionClinical recognition, appropriate diagnostic modalities, and informed treatment of PPCM in Malawi will improve care of peripartum woman and reduce maternal morbidity and mortality.
Characteristics of soils for civil engineering foundations in part of North Central Nigeria, using electrical resistivity method
Authors: Ayanninuola O. S. , Msughter U. D. , Ofoegbu C. O. , Uko E. D.
Published: October 2023

A geophysical investigation was carried out using Vertical Electrical Sounding (VES) in part of North Central Nigeria to evaluate the subsoil thickness, competence, and corrosivity for civil engineering foundations. A total of 60 VES stations were covered within the study area using the Schlumberger configuration array with half current electrode separation (AB/2) varying from 1m to a maximum of 100m while the half potential electrode spacing (MN/2) varied by 0.3 m to a maximum of 5m. The analysis of data was done using IP2win and Surfer 12 softwares. The first layer has resistivity values between 4.728 Ωm to 4210 Ωm and varied in thickness between 0.15 m to 1.42 m, the second layer has resistivity values between 24.7Ωm to 355000 Ωm and varied in thickness between 0.0355 m to 8.983 m while the third layer has resistivity values ranging between 8.361 Ωm to151,608 Ωm and varied in thickness between 1.05 m to 34.2 m, the fourth layer which is the last of the geoelectric layers has resistivity values between 27.95 m to 77000 m. The subsoil within the study area is composed of clay, sandy clay, clayey sand, sand, and laterite. From the qualitative interpretation of the Isoresistivity and Isopach maps, the Southwestern, Southeastern and Northwestern parts of the study area are moderately corrosive to extremely corrosive subsoil with resistivity values ranging between 4.728 Ωm and 50.48 Ωm. The third layer consists of an incompetent low resistivity soft material that underlain the entire study area except at the central region which is essentially noncorrosive and highly competent. VES curves interpretations revealed the thickness and depths of the geoelectric layers within the study area. The results of this research could enable civil engineers to ascertain the requisite depth of soil evacuation for the sustainability of structures within the study area.
Physico-chemical and bacteriological assessments of shallow well water samples during the dry and rainy seasons
Authors: Ayeni O. O. , Oyegoke S. O. , Ndububa O. I. , Adetoro A. E.
Published: October 2023

There is need to study the impact of seasonal variations on well water quality especially in Ado – Ekiti metropolis as this will assist in creating awareness on groundwater quality for domestic consumption. The quality of groundwater obtained during dry and rainy seasons from 60 privately utilized hand-dug closed wells in Ado Ekiti metropolis were assessed. Physicochemical and bacteriological investigations were carried out according to required standards. The temperature, colour, turbidity, pH, total solids, chlorides, sulphate, calcium, magnesium, nitrate, and iron, which are physico-chemical parameters of the well water samples ranged from 24.7 to 25.6 °C, 4.1 to 7.3 HU, 3.7 to 6.9 NTU, 7.3 to 7.5, 95.7 to 211.1 mg/L, 38.6 to 74.6 mg/L, 34.3 to 64.9 mg/L, 24.3 to 49.4 mg/L, 48.1 to 89.0 mg/L, 0.4 to 0.8 mg/L and 0.05 to 1.0 mg/L respectively. Despite the fact that the parameters were within the acceptable ranges, bacteriological studies showed the presence of E. coli (ranged from 19.5 to 81.6 CFU) throughout the seasons, thus, individuals who rely on groundwater for their health are exposed to disease-causing organisms. Deductions from the correlation matrix equally, demonstrated the relative dependence of the parameters on one another as they variate according to the change in weather. Mostly during the rainy seasons, higher concentrations of the physicochemical and bacteriological parameters were observed than during the dry seasons, proving that the rainy seasons aid anthropogenic activities from the surface to transmit dissolved harmful waste materials to the subsurface which eventually finds its paths into the groundwater. Improper disposal of faeces, faulty soak-pits, latrines, dumpsites and burial grounds are part of the factors that contribute to bacteriological pollutants in the groundwater source.
Electrolytic co-deposition of Zn-ZnO and Zn-ZnO-CaCO3 composite substrates on low-carbon steel
Authors: Nnaji R. N. , Bodude M. A. , Esezobor D. E.
Published: October 2023

Conventionally employed zinc-rich paints and coatings for marine corrosion protection of steel still comprise environmentally unfriendly compounds such as zinc phosphate. This paper is focused on developing eco-friendly zinc ternary composite coatings of Zn-ZnO-CaCO3 utilizing CaCO3 additives derived from tympanotonus fuscatus (periwinkle) shell and calcareous eggshell respectively on low-carbon steel using electrodeposition technique. This is aimed at improving not only the surface corrosion resistance of steel structures in marine environment but also the sustainability of raw materials and minimal environmental pollution. Corrosion studies of uncoated and coated steel samples in simulated marine environment were done using linear polarization technique. Results obtained suggested that CaCO3 (i.e., calcareous eggshell) additive in the composite coating significantly improved the corrosion performance of the substrate. Steel coated with calcareous eggshell additive displayed superior corrosion performance having highest polarization resistance, Rp (156090 Ω), lowest corrosion rate, CR (0.01 mm/year) and highest coating efficiency, Ceff (97%) as against those of uncoated, zinc oxide, and tympanotonus fuscatus shell additives after 30 minutes deposition time. Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS) results of selected developed coatings indicated presence of a homogeneous surface morphology and a significant amount of calcium in the calcareous eggshell coating.
Aspartame induced dyslipidemia and plasma hyperviscosity in Albino Wistar rats
Authors: Eiya B.O. , Osunbor J.O.
Published: October 2023

Aspartame is a low-calorie sweetener that has been used for decades in place of sugar. However, there has been conflicting reports on the use and safety profile of aspartame associated with several diseases especially cancer and cardiovascular diseases. This study therefore aims to determine the effects of aspartame on some cardiovascular indices. Thirty seven (37) young Albino Wistar rats weighing between 110g-140g were used for this study. The rats were divided into five groups; control (5) received 5 ml of distilled water. Group 1 (n=8) received 5 ml of diet soda, group 2 (n=8) received 5 ml diluted (1:1) diet soda, Group 3 (n=8) received 5 ml aspartame 45 mg/kg b.w, Group 4 (n=8) received 5 ml of aspartame 22.5 mg/kg b.w. The various doses of aspartame and diet soda were administered orally daily for ten weeks. Weight of the rats were taken weekly, at the end of the experimental period, the rats were sacrificed and blood samples collected into plain sample bottles and tri sodium citrate bottles. Lipid profile (total cholesterol, HDL-C, LDL-C &.triglyceride) were analyzed spectrophotometrically, fibrinogen and blood viscosity were also measured. Results showed that the aspartame and diet soda significantly increased total cholesterol, triglyceride, LDL-C, fibrinogen and plasma viscosity and significantly decreased HDL cholesterol. In conclusion, consumption of aspartame as a sweetener can impact negatively on cardiovascular haemodymic factors. Therefore, its intake should be discouraged.
Activities of leaves extracts of Vernonia amygdalina and Abrus precatorius against selected antibiotic resistant bacterial pathogens
Authors: Nmema E.E. , Oladimeji A.O. , Akinmade R.F. , Akinnusi P.O.
Published: October 2023

Ethanol and methanol extracts of Vernonia amygdalina and Abrus precatorius leaves were screened respectively against multi-antibiotic-resistant clinical isolates of Klebsiella pneumoniae, Salmonella enterica var. Typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae by agar-well diffusion method using graded concentrations of extract (200 mg/mL, 100 mg/mL, 50 mg/mL, 25 mg/mL, 12.5 mg/mL). Inhibition zone sizes (IZDs) produced by decreasing concentrations of V. amygdalina were recorded as Klebsiella pneumoniae (20 mm, 20 mm, 13 mm, 10 mm and 0 mm); Salmonella enterica var. Typhi (18 mm, 18 mm, 13 mm, 0 mm and 0 mm); Pseudomonas aeruginosa (18 mm, 18 mm, 13 mm, 0 mm and 0 mm); Staphylococcus aureus (15 mm, 15 mm, 10 mm, 0 mm and 0 mm); Streptococcus pneumoniae (17 mm, 17 mm, 15 mm, 0 mm and 0 mm). A. precatorius produced IZDs against Klebsiella pneumoniae (15 mm, 11 mm, 10 mm, 0 mm and 0 mm); S. enterica var. Typhi (16 mm, 13 mm, 9 mm, 0 mm and 0 mm); Pseudomonas aeruginosa (13 mm, 11 mm, 10 mm, 0 mm and 0 mm); Staphylococcus aureus (13 mm, 11 mm, 9 mm, 0 mm and 0 mm); Streptococcus pneumoniae (17 mm, 13 mm, 10 mm, 0 mm and 0 mm). The results suggest that extracts of V. amygdalina and A. precatorius leaves exert broad spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. These findings support the widespread use of the plants as local remedy for a variety of ailments, and indicate the potential roles of the plants in drug development programs of the pharmaceutical industry.
Textural characteristics and sediment transport dynamics of the sandstones of the Nkporo group, Southern Anambra Basin (Nigeria): evidence for the upper cretaceous sea-level lowstand
Authors: Ugwueze C.U. , Okengwu K.O.
Published: October 2023

The Anambra sedimentary basin is one of the major inland basins in Nigeria. It covers an area of approximately 30,000 square kilometres and is named after the Anambra River, which traverses the basin. The geology of the basin is characterized by a complex sequence of sedimentary rocks that record a long history of deposition and tectonic activity. Detailed and systematic field investigation of its rock sequences exposed at Leru junction and adjoining localities revealed five dominant lithologic units consisting of massive sandstone facies, argillaceous sandstone facies, fissile black shale and mudstone facies, planar and ripple laminated sandstone facies, and massive and pebbly sandstone facies. The area is dominated by transgressive facies characterized by alternating sequences of thinly and parallel laminated fissile black shales, mudstones, and argillaceous sandstones overlain by regressive deposits dominated by massive and partly pebbly sandstones. The transgressive sequences perhaps represented shelf mud sedimentation that was probably interrupted by episodic influxes of sands rich in argillaceous materials transported down the shelf probably by shoreface waves or gravity-driven flows, while the regressive facies may have probably been emplaced by liquefied sand flows of the frontal slope of an advancing mouth bar. The erosion of the shelf deposits by the pebbly sandstones possibly reflected seaward migration of shallow distributary channels during sea-level low stand. Thus, facies transition from argillaceous sandstones to massive and pebbly sandstones within the continental shelf perhaps signified a fall in the relative sea level possibly triggered by the erosion of the shelf or perhaps a high rate of sediment supply.
Measurement of leakage radiation dose to patients undergoing chest x-ray in some x-ray facilities in Warri Town. Nigeria.
Authors: Ovwasa S.O. , Akpolile A.F. , Agbajor G.K. , Mokobia C.E.
Published: October 2023

The increase in the application of x-ray in health management has necessitated the need to determine the risk associated with its use. This study is aimed at measuring the leakage radiation dose to patients undergoing chest x-ray in twenty (20) radiological facilities in Warri, Delta State. A portable GMC-600 digital Geiger Muller Counter (serial number: 36311386254310) was used to examine the facilities. The leakage radiation was measured from both the cathode and anode terminals of the machines across the facilities studied and their mean exposure readings were obtained. The leakage radiation (mR/hr) values for the cathode terminal ranges from 0.21 – 100.27 mR/hr with an average of 26.46 mR/hr while the anode terminal is from 0.21 – 99.70 mR/hr with an average of 24.88 mR/hr. From the obtained results, it was observed that only one machine, A10 (100.27 mR/hr) exceeded the recommended limit (100 mR/hr) for leakage radiation as stipulated by American Association of Physicist in Medicine (AAPM). This indicates that the workers and members of the public in the said facility could be exposed to some level of harmful radiations.
Excess parameters of binary mixtures of acetonitrile- dimethyl sulphoxide
Authors: Orjiocha SI , Orjioke NM , Ibezim-Ezeani MU
Published: October 2023

The excess parameters associated with liquid mixes of acetonitrile-dimethyl sulphoxide were analyzed to estimate the degree of intermolecular interactions in the binary system. The viscosities and densities of the binary system were determined at temperatures of 298.15, 303.15, 318.15, 328.15, and 338.15K, respectively, with a percentage composition of 0 to 100 percent. Using the experimental density and viscosity measurements, the excess molar volumes (VmE), excess viscosity (nE), excess Gibbs' free energy of activation of viscous flow (G*E), and Grunberg-Nissan interaction parameters were calculated. Deviations from these parameters studied in the composition of the mixtures and temperature were discussed in terms of molecular interactions in these mixtures. A comparison of several interaction characteristics was expressed to better understand the intermolecular interactions between acetonitrile and dimethyl sulphoxide. As the temperature of the system and the mole fractions of acetonitrile rise, the viscosity and density of the experimental values drop. According to the findings, the excess parameters were mostly negative, indicating that dipoledipole interactions predominated in the acetonitrile-dimethyl sulphoxide solvent mixture.
Malachite green sequestration from aqueous system by untreated Dacryodes edulis seed
Authors: Overah L.C. , Ebite C. , Ujor A.
Published: October 2023

This paper presents an assessment of the kinetics and thermodynamics of malachite green (MG) abstraction from an aqueous system onto untreated pear seed (Dacryodes edulis) biomass as an adsorbent at pH 12. The experiments were conducted in batches at 25 °C, with a biomass dose of 0.5 g, and at different durations (5 to 240 minutes) using a 50 mg/L malachite green dye solution. The kinetics data were examined using four models: pseudo-first-order, pseudo-second-order, intraparticle, and Elovich models. The fallouts indicated that the pseudo-second-order model represented the process’ kinetics well, with R2 values of 0.9998, rate constant, 0.346 g/mg/min, and a 90% adsorption efficiency. Thermodynamics study revealed a negative free energy change, ΔGº, indicating a feasible and spontaneous process that is endothermic, having a positive ΔHº. Comparing the findings with the findings of others reveals that malachite green adsorption onto various adsorbents is usually endothermic and follows the Pseudo-second-order mechanism most times. Overall, untreated pear seed biomass has the potential as an alternative to traditional adsorbents for extracting malachite green from an aqueous medium.
Detection and diagnosis of Salmonella typhi from stool and blood samples using Widal, Tubex-tf and polymerase chain reaction
Authors: Zige D.V. , Omeje F. I
Published: October 2023

There are currently no effective, quick, and sensitive techniques for identification of Salmonella serovar Typhi. Typhoid fever is difficult to diagnose clinically in highly endemic areas, since the symptoms are vague and similar with other febrile disorders such as malaria, and dengue fever. Considering the challenges involved with typhoid diagnosis by blood culture and serology, the PCR approach has lately been used, however it is not the gold standard for typhoid diagnosis. The aim of this study is to determine the best diagnostic method used for detection of typhoid fever using Widal test, Tubex-tf and fecal culture for the detection of typhoid. Blood and stool samples were collected from febrile patient and were screened by Widal and Tubex-tf tests, while stool samples were screened for Salmonella Typhi by culture and PCR for confirmation. The results of stool samples obtained after screening by culture, biochemical tests and confirmation by PCR did not confirm Salmonella Typhi bacteria. The 28 blood samples have a corresponding rate of 0% Tubex-tf and Widal was 93.3%. Therefore, this study suggests that Tubex-tf should be offered in typhoid-endemic areas and also recommends its use in the diagnosis of typhoid fever because the results obtained correlate with stool culture leading to PCR Confirmation. Accurate diagnosis before establishing a case of febrile typhoid fever is very important, similarly, sensitivity should dictate the best of antibiotics to be used for treatment.
Stochastic modelling of wind speed over northern states in Nigeria
Authors: Agada I.O. , Peter O. , Agada P.O.
Published: October 2023

This paper presents a stochastic modeling of wind speed over sixteen (16) Northern states in Nigeria using thirty-seven years (1984-2020)  wind speed real time data. A Markov Chain Model was developed for the monthly wind speed state across study locations. In  order to obtain the Markov chain transitional probabilities, the wind speed data was categories into various states using the Beaufort  wind scale. It was observed that only the first four description of wind speed state A, B, C and D exist in the study locations. Uniform  random states were also formed by generating uniform random number. The comparison of monthly simulated and actual wind speed  state clearly shows that the model simulated over six months correctly across study locations except Niger. Given a current wind speed  state conditions, the stochastic models available in this paper can be adapted to generate future wind speed state condition. The  understanding of wind speed state helps in wind turbine design and selection of wind farm sites for wind energy generation.
Modeling and forecasting electricity consumption in Nigeria using Arima and Arimax time series models
Authors: Maku T.O , Adehi M.U. , Adenomon M.O.
Published: October 2023

This study compared the extrapolation strengths of two models: Autoregressive Integrated Moving Average (ARIMA) and Autoregressive  Integrated Moving Average with an Exogenous Variable (ARIMAX) in the forecast of Nigeria's electricity consumption. Annual data on  power generation and consumption from the Central Bank of Nigeria statistical bulletin for 2006 and 2016 over a 51-year period  (1970-2020) was used. Industrial and residential electricity consumptions were examined for possible unit roots (non-stationarity) using  the Augmented Dickey-Fuller test approach. The ADF test result showed that the time series achieved a stationary state for the variables  under consideration at first difference. Akaike Information Criterion (AIC) and Root Mean Square Error (RMSE) were used to assess the  performance of each models. Comparing the ARIMA and ARIMAX forecast models, ARIMA(0, 1, 1) emerged for modelling and forecasting industrial electricity consumption in Nigeria while ARIMAX (1, 1, 1) with installation capacity as exogenous variable was suitable for modelling and forecasting residential electricity consumption in Nigeria. The study recommended that for optimal residential electricity  consumption in Nigeria, installation capacity and the total power generation in Nigeria should be enhanced.
Functional, chemical and organoleptic properties of moi-moi prepared from blends of cowpea (Vigna unguiculata) and sprouted pigeon pea (Cajanus cajan) flours
Authors: Arukwe D.C. , Okoli J.N. , Chimezie U.G.
Published: October 2023

Moi-moi is a steamed bean paste usually made from cowpea paste blended with seasonings and other ingredients. This study was carried out to evaluate the functional, chemical and sensory properties of moi-moi produced from cowpea and sprouted pigeon pea flour  blends. Flours were produced from cowpea and sprouted pigeon pea and blended in the ratios of 100:0, 95:5, 90:10, 85:15, 80:20  and 50:50, where 100% cowpea served as the reference sample. The functional properties of the composite flours, proximate, mineral,  and sensory characteristics of the moi-moi were evaluated. Functional properties ranged from 0.67 to 0.69 g/ml for bulk density, 1.33 to  1.70 ml/g for swelling index, 1.80 to 2.03 g/g for water absorption capacity, 1.27 to 1.73 for oil absorption capacity, 40.17 to 46.57 % for  emulsion capacity and 30.30 to 34.00 % for foam capacity. Proximate composition results revealed that crude protein, crude fibre, and ash  increased while moisture, fat and carbohydrate decreased with increased substitution of cowpea with sprouted pigeon pea. Mineral  contents increased with increasing level of sprouted pigeon pea addition with values ranging from 26.30-63.37 mg/100g, 39.00-51.50 mg/100g, 272.00 to330.27 mg/100 g, 14.10 to 43.90 mg/100 g and 413.33-434.13 mg/100g for calcium, magnesium, potassium, sodium  and phosphorous respectively. Sensory analysis revealed that moi-moi produced from 90% cowpea and 10% sprouted pigeon pea flour  possessed the best organoleptic properties among the test samples. This study has demonstrated the production potential and  nutritional benefits of sprouted pigeon pea complementation in the production moi-moi from cowpea.
Isolation, biochemical and molecular characterization of lactic acid bacteria from whey of a Nigerian traditionally fermented yoghurt drink
Authors: Oyedokun N.O. , Oyeleke S.B. , Abioye O.P. , Bala J.D.
Published: October 2023

Lactic Acid Bacteria (LAB) have been identified as an essentialgroup of microorganisms due to the health-promoting effects theyexert on human and animal hosts. This research was conducted to,isolate LAB from whey obtained from kindirmo a locally fermentedcow milk product in Nigeria, characterize the strains based onphysiological and biochemical properties and identify them using16SrRNA sequencing. A total of 32 samples were collectedaseptically and the whey cultured on an MRS and M17 media.Physiological and biochemical results showed that the isolatedorganisms, which were mostly rod and cocci shaped, includedgram positive and catalase negative species. The organisms didnot only vary in their abilities to tolerate and grow at differentconcentrations of pH, temperature and NaCl, but were able toferment twelve different sugars distinctively. The ten most desirablestrains obtained were subsequently screened by moleculartechniques using PCR and sequence analysis. The PCR resultsrevealed that 98% of the identified organisms were Lactobacillusbulgaricus, Lactobacillus casei, Lactobacillus acidophilus,Streptococcus thermophilus, Lactobacillus gasseri andLactobacillus plantarum. These findings showed that kindirmocould be an excellent and potential source of probiotic bacteria,which are often the main sources of probiotics. Further screeningand identification processes were recommended to ascertain thefunctional, technological and probiotic properties of the strains.
Studies on the industrial applications of limestone samples from three geographical regions in Nigeria: Ashaka, Mfamosing, and Nkalagu
Authors: Micheal Prince , Chukwu Uche John
Published: October 2023

The chemical properties of limestone have been the subject of several studies in recent years, highlighting its importance in various  industrial applications. The present study focuses on six limestone samples from three geographical regions in Nigeria (Ashaka,  Mfamosing, and Nkalagu). The analyses of their chemical composition using the Loss on Ignition Test and X-Ray Fluorescence  Spectrometry was successfully carried out. Results of the study show that CaO is the main component, comprising between 60.054 % and  78.632 % of the samples. Values of Loss of Ignition (LOI) ranged from 30.820 % to 33.280 % while SiO2 composition ranged between 5.095  % to 12.238 %. Other oxides detected, include Al2O3 and Fe2O3, which make up less than 1 % of the composition. Obtained values were  compared to Limestone standards for various industries and findings indicate that the Ashaka, Mfamosing, and Nkalagu limestone  samples are of high purity and suitable for use in various industrial fields, including the steel industry, manufacture of bleaching powder,  manufacture of calcium carbide, sugar industry, textile manufacture, cement industry, agricultural practice (soil liming), and flue gas desulphurization. Thus limestone deposits from Ashaka, Mfamosing, and Nkalagu has more potential and application uses beyond  cement production which they are currently used for
Synthesis, spectroscopic determination and in vitro antimicrobial studies of cobalt(ii) and nickel(ii) complexes of a Schiff base derived from 1h-indole-2,3- dione with hydrazinecarbothioamide
Authors: Isyaku S. , Bello J. , Aliyu H.N. , Abubakar T. , Imam M.
Published: October 2023

Condensation of H-Indole-2,3-dione with Hydrazinecarbothioamide produced a Schiff base (2Z)-2-(2-Hydroxy-3H-indol-3- ylidinehydrzinE- 1-Carbothioamide. Cobalt(II) and Nickel(II) complexes, were prepared by the interaction of the metal(II) salts with the synthesized Schiff  base. The prepared compounds were analysed by magnetic susceptibility, molar conductance, FTIR, AAS, solubility absorbance and  empirical formula. The complexes showed moderate values of decomposition temperatures. Infrared spectral data of the Schiff base and  the complexes, indicated coordination of the Schiff base to the metal(II) ions via azomethine nitrogen, indole oxygen and thione sulphur.  The effective magnetic moment of the complexes suggested an octahedral geometry. The molar conductivities indicated a non- electrolytic nature of these complexes. The results of the absorbance and the empirical formula showed that, the Schiff base is  monobasic and tridentate in nature towards the metal ions. Both the ligand and the complexes were screened for antimicrobial activity  against Staphylococcus aureus, Salmonella typhimurium, Escherichia coli (bacteria); Aspergillus flavus, Aspergillus fumigatus and Mucor (indicus  species) (fungi). Amoxicillin and Ketoconazole were used as positive control for the bacteria and fungi isolates respectively. The results  showed that the complexes are more active than the free ligand but less active when compared with the standards.
Impact of dust particles on the output power of photovoltaic modules in Calabar, Cross River State
Authors: Oyom Everest Bassey , Ettah Emmanuel Bajamin , Akonjom Nsed Ayip
Published: October 2023

During the dry season, dust particles on photovoltaic modules (PV modules) are a regular occurrence in Calabar, Cross River State. This  dusty condition or environment is caused by the migration of dust particles from the Sahara region via the east-west wind. The concentration of dust on PV modules has an impact on the overall performance of solar energy systems. This research looks into the effect of dust particles on the output power of solar modules. This investigation was carried out by subjecting 80-watt monocrystalline PV  modules to an outdoor experiment and analyzing the changes in current and voltage from the control and dusty PV modules with a  digital multimeter. Other environmental factors such as relative humidity, ambient temperature, and solar radiation were also measured  with a hygrometer, thermometer, and solar power meter respectively. Appropriate formulars were employed to calculate output power  and efficiency. Dust particles on the surface of PV modules dramatically reduces the quantity of sunlight that penetrate the panel by  21.10%, resulting in a drop in the system's overall output power. The study emphasizes on the importance of frequent cleaning and  maintenance of PV systems.
FXR1 knockdown inhibits the malignant behavior of colorectal cancer by suppressing epithelial-tomesenchymal transition
Authors: Du Qindan , Chen Jiayao , Li Honglei , Bian Yixin , Wang Xiaoying , YQ Chen , Ge Xiaosong
Published: October 2023

Purpose: To determine the role of Fragile X-related protein-1 (FXR1) in colon cancer progression and its relationship to patients’ survival.Methods: A total of 164 colorectal cancer (CRC) patients, admitted to the Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China between 2006 and 2008, were included in this study. Immunohistochemistry was used to semi-quantitatively analyze the intensity and extent of immunological staining of diaminobenzidine-stained paraffin blocks of CRC samples. The study also retrieved COAD mRNA and patients’ clinical data from TCGA and cultured human colon cancer cell lines (SW480, SW620, HCT8, HCT116, and Caco2) in RPMI 1640 medium to assess the propensity of CRC cells to proliferate, invade the tumorigenicity in BALB/c nude mice.Results: The prognosis of CRC patients was inversely linked with the expression of FXR1. Additionally, FXR1 knockdown in CRC cells reduced cellular growth, colony development and tumorigenesis. After presenting BALB/c nude mice with tumors in FXR1 knockdown, the cells displayed higher E-cadherin levels (p < 0.01) as well as decreased TGF-1 (p < 0.01) and N-cadherin levels (p < 0.001).Conclusion: Fragile X-related protein-1 is an oncogene in colon cancer and its knockdown inhibits HCT116 cells from behaving malignantly. Thus, FXR1 is a potential treatment option for CRC.
Combined sevoflurane/sufentanil anesthesia for removal of tracheal foreign bodies in pediatric surgery, and its effect on hemodynamics
Authors: Gong Huaqu , Liu Tingting , Duan Lirong , Duan Lirong , Wang Haiyang
Published: October 2023

Purpose: To determine the efficacy of sevoflurane + sufentanil combination anesthesia in pediatric surgery for removal of tracheal foreign bodies, and its effect on hemodynamics.Methods: A total of 128 children with airway foreign bodies were assigned to control and study groups, each with 64 children. The control patients received slow intravenous injection of propofol (3 mg/kg). The study group was given 5 % sevoflurane and a slow intravenous injection of sufentanil (0.3 μg/kg). Hemodynamic parameters (diastolic blood pressure, systolic blood pressure and heart rate) were recorded before induction of anesthesia, at the time of intubation, during placement of a rigid bronchoscope (when the lens was placed), during removal of foreign bodies, and when extubating. Complications in children in the two groups after the removal of airway foreign body were recorded.Results: At the times of intubation and extubation, blood pressure and heart rate were significantly increased in both groups, but appreciably lower values were seen in study group. The major complications in pediatric airway foreign body removal in two groups were vomiting, bronchospasm and holding of breath.Conclusion: In children with airway extraction, sevoflurane, in combination with sufentanil produced better anesthetic effect and less impact on hemodynamics than propofol. Moreover, the children woke up faster and had fewer complications. The combined anesthesia is safe and reliable. However, the clinical application of this combined anesthesia requires larger-sample clinical studies.
Effect of entecavir on IL-6/STAT3/SOCS3 pathway in patients with chronic hepatitis B-induced liver fibrosis
Authors: Wang Shuqiao , Sui Ziqi , Peng Kaili , Cheng Hefei
Published: October 2023

Purpose: To evaluate the impact of entecavir (ENT) on patients with liver fibrosis resulting from chronic hepatitis B (CHB) and its association with the interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3)/suppressor of cytokine signaling 3 (SOCS3) pathway.Methods: Thirty-one patients with liver fibrosis received ENT at a dose of 0.5 mg/day for 48 weeks. Relevant protein levels in patient’s serum before and after treatment were assayed using enzyme-linked immunosorbent assay (ELISA). Furthermore, human hepatic stellate cells (HSCs) were cultured in vitro and divided into three groups: control, transforming growth factor beta 1 (TGF-β1) induction (TGF-β1 group), and ENT treatment (TGF-β1 + ENT group). Protein levels in the supernatant were assayed using ELISA, while the expression levels of related genes were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Expression of α-SMA was visualized using immunofluorescence assay and the relevant protein levels were determined by Western blotting.Results: Treatment with ENT significantly decreased (p < 0.01) IL-6 and STAT3 expression, increased SOCS3 expression and significantly reduced (p < 0.01) the concentrations of hyaluronic acid (HA), type IV collagen (IVC), laminin (LN) and pro-collagen type III (PCIII) in patients with liver fibrosis. TGF-β1 significantly (p < 0.01) elevated IL-6, STAT3 and Col-I expressions and a tissue inhibitor of metalloproteinases-1 (TIMP-1) suppressed the expression of SOCS3 in human HSCs and induced fibrosis. Entecavir mitigated TGF-β1-induced fibrogenesis in HSCs (p < 0.01).Conclusion: Entecavir has a positive effect on liver fibrosis resulting from CHB by regulating IL- 6/STAT3/SOCS3 pathway. Future research will focus on conducting larger clinical trials to further validate these findings and explore the long-term effects of ENT on liver fibrosis progression and patient outcomes.
Blending Eclecticism and Specificity: The Art of Nollywood Epic Film Costumes
Authors: Okadigwe Mary Nkechi
Published: October 2023

This research explores the unique approach to costume design in Nollywood, the Nigerian film industry. It focuses specifically on the epic  film genre and discusses how Nollywood costume designers blend a variety of cultural and historical influences to create costumes that  are both authentic and visually striking. It argues that this approach to costume design reflects the eclecticism and diversity of Nigerian  culture while also highlighting the specificity and hybridity of the ethnic costumes represented in the film. Drawing on a close analysis of  costume designs in Fred Amata’s Ijele (1999) and Kingsley Orji’s Eyes on the Throne (2019), the article offers insights into the creative  processes and cultural context that inform this distinctive style of costume design. It uses the cultural hybridity theory by Bhabha Homi to explore the unique approach to costume design in films. Ultimately, the article demonstrates the importance of costume design in Nollywood epic films and argues that it plays a crucial role in constructing the visual and narrative world of these films
Omenala Ikpu Ozu Akwa n’Agụlụ: N’Oge Gboo na Oge Ugbua
Authors: Akpulu Esther Ogochukwu
Published: October 2023

Igbo traditional rites are among the things that distinqush themfrom other nations. These rites are considered as parts of Igbotraditional practices. The elders are expected to be the custodiansof the Igbo valuable traditional practices. Some burial rites andceremonies are exceptional and given special meaning andattention. Covering the corpse with wrapper before it is buried isone of the Igbo traditional burial rites. Most Igbo communitiesincluding Agụlụ perform this rite for their deceased but the modusoperandi is peculiar to each community. Some people see thisburial rite as an inherited tradition but are ignorant of what itentails. The objectives of this study include highlighting thisburial rite “covering the corpse with wrapper” and making thepublic know about it. It also intends to x-ray the rite and knowwhy Agụlụ community cover corpse with wrapper before buryingit. The theoretical framework was anchored on SymbolicInteractionism. Research method used was descriptive and surveymethod. Among the findings of this study is that covering thecorpse with wrapper symbolizes good relationship between thedeceased and those covering it. It also finds out that somedeceased are not entitled to this rite. The study recommends thatIgbo people promote and project their culture rather thanjettisoning their ways of life in quest for foreign cultures. It isequally important that Igbo anthropology scholars persistentlyresearch on the essence of most Igbo traditional practices whichwill aid continuous promotion of Igbo culture.
PERANCANGAN LABUAN BAJO CONVENTION CENTER
Authors: Eduardus Hatu  , Putu Gde Ery Suardana  , Desak Made Sukma Widiyani
Published: October 2023

Abstrak

Perancangan Labuan Bajo Convention Center ini pada dasarnya merupakan wadah atau sarana komunikasi antara dua pihak dengan penerapkan berbagai metode komunikasi langsung tatap muka baik itu dari perorangan terhadap kelompok, kelompok terhadap kelompok atau kelompok terhadap masyarakat. Dan pada era kini hal ini menjadi suatu kebutuhan yang dianganggap penting. Kota Labuan Bajo, seringkali menjadi tuan rumah suatu konverensi dengan jumlah peserta yang tergolong besar karena cakupannya sampai manca negara.hal ini mendorong laju pembangunan dalam kota termasuk rencana pembangunan Convention Center di Labuan Bajo yang nantinya dirancang dengan dasar penerapan tema Arsitektur Hich tech merupakan kebutuhan objek rancangan sebagai Convention yang lingkupnya regional atau nasional maupun internasional. penerapan tema Making structure (penonjolan struktur) melalui kajian yang ada diharap dapat mengoptimalkan fungsi bangunan, memberikan kenyamanan serta meningkatkan kepariwisataan kota Labuan Bajo.

Kata Kunci: Perancangan Convention, High Tech, Labuan,Bajo.

Abstract

The design of the Labuan Bajo Convention Center is basically a forum or means of communication between two parties by applying various methods of face-to-face direct communication, be it from individuals to groups, groups to groups or groups to the community. And in this era, this has become a necessity that is considered important. Labuan Bajo City, often hosts a convergence with a relatively large number of participants because of its scope to foreign countries.this encourages the pace of development within the city including the plan to build a Convention Center in Labuan Bajo which will be designed on the basis of the application of the theme Hich tech architecture is the need for design objects as Conventions  whose scope is regional or national or international.  Making structure through existing studies is expected to optimize the function of the building, provide comfort and improve tourism in labuan Bajo city.

Keywords: Convention Design, High Tech, Labuan Bajo.
KONSEP PERANCANGAN PASAR WAE KESAMBI SEBAGAI PASAR TRADISIONAL MODERN
Authors: Ceminta wawan
Published: October 2023

Kawasan Pasar wae kesambi adalah salah satu pasar tradisional di labuan bajo kabupaten manggarai barat. Kawasan pasar ini terletak di bagian Timur kota labuan bajo. Pasar wae kesambi merupakan tempat jual beli barang ataupun jasa. Rumusan masalah dalam penulisan ini adalah bagaimana Konsep Perancangan pasar wae kesambi  di Kabupaten manggarai barat. Metode pengumpulan data menggunakan metode observasi, wawancara, kuisioner serta data sekunder yang diperoleh dari dokumen-dokumen, peraturan-peraturan yang berkaitan dengan masalah yang akan diteliti. Sedangkan metode analisa yaitu deskriptif, pengelompokan data, analisis dan sintesis hingga menemukan solusi dari masalah yang ada. Berdasarkan hasil penelitian, Konsep perancangan pasar wae kesambi membantu peneliti memberikan arahan konsep perancangan pasar wae kesambi menjadi lebih baik. Hasil analisa menunjukan bahwa konsep perancangan pasar wae kesambi meliputi tapak kawasan pasar.

 

The Wae Kesambi Market area is one of the traditional markets in Labuan Bajo, West Manggarai Regency. This market area is located in the eastern part of the city of Labuan Bajo. Pasar Wae Kesambi is a place for buying and selling goods or services. The formulation of the problem in this paper is how is the design concept of the Wae Kesambi market in West Manggarai Regency. Methods of data collection using observation, interviews, questionnaires and secondary data obtained from documents, regulations relating to the problem to be studied. The analytical method used is descriptive analysis method, data grouping, analysis and synthesis to find solutions to existing problems. Based on the results of the research, the concept of designing the wae kesambi market helps researchers provide direction for the design concept of the wae kesambi market to be better. The results of the analysis show that the design concept for the Wae Kesambi market includes the market area footprint.
DAMPAK ARSITEKTUR TERHADAP IKLIM YANG MEMPENGARUHI KEAWETAN BAHAN BANGUNAN DI DAERAH ASAH GOBLEG DI KABUPATEN BULELENG
Authors: Chrestofer William Daniel  , Benediktus Dairo Bio  , I Wayan Gunarta
Published: October 2023

Arsitektur bangunan yang menyesuaikan diri dengan alam dan iklim sangat banyak dijumpai di permukaan bumi   yang tersebar di berbagai wilayah pembagian iklim. Bangunan tersebut masih tetap eksis atau bertahan hingga sekarang atau terjaga sustainabilitasnya. Salah satu indikator keberhasilan bangunan dalam menjaga keberadaannya adalah pemakaian energi yang efisien atau hemat. Masalah penelitian adalah bagaimana dan dampak apa saja yang di pengaruh iklim terhadap bangunan pada daerah Asah Gobleg di Kab. Buleleng serta bahan bangunan apa saja yang sesuai dengan iklim pada daerah Asah Gobleg di Kab. Buleleng? Metode yang digunakan adalah metode survey, interview dan studi literatur. Hasil penelitian: Desa Gobleg berada di daerah ketinggian yang berhawa dingin, sehingga bangunan di Desa Gobleg sebagian besar menggunakan atap seng dan bangunan tidak terlalu tinggi, karena difungsikan untuk menampung hawa panas yang di sebabkan oleh sinar matahari yang memantuk ke atap seng. Semua pengaruh alam baik itu iklim, radiasi matahari, kelembaban dan curah hujan adalah hal yang tidak biasa dihindari dalam dunia arsitektur hal ini akan terus terjadi namun semua ini bisa diantisipasi dengan lebih mengetahui penyebab dan cara mengatasinya.

Building architecture that adapts to nature and climate is very much found on the surface of the earth which is scattered in various climatic division areas. The building still exists or survives today or is maintained its sustainability. One of the indicators of the success of buildings in maintaining their existence is the efficient or efficient use of energy.  The research problem is b agaimana and what impacts are influenced by climate on buildings in the Asah Gobleg area in Buleleng Regency  and whatbuildings are suitable for the climate in the Asah Gobleg area in Buleleng Regency? The methods used are surveys, interviews and literature studies. Research results:  Gobleg Village is located in a cold altitude area, so the buildings in Gobleg Village  are large in part using zinc roofs and buildings are not too high, because they are functioned to accommodate the heat caused by sunlight yang squeezing onto the zinc roof.  All natural influences be it climate, solar radiation, humidity and rainfall are unusual things to avoid in the architectural world this will continue to happen but all this can be anticipated by knowing more about the causes and how to overcome them.
PERENCANAAN PENATAAN PURA TIRTA MAS DAN PURA PASAR AGUNG SEBAGAI PETANDA AREAL SUCI DI KAWASAN PURA SAD KAHYANGAN LUHUR ANDAKASA, KARANGASEM
Authors: Ar. Ir. I Wayan Wirya Sastrawan, S.T., M.Sc.  , Ar. Ir. I Gede Surya Darmawan, S.T., M.T.  , Ir. I Wayan Widanan, S.T., MPM.
Published: October 2023

Pura Luhur Andakasa adalah salah satu pura bagian dari Sad Khayangan yang ada di Bali. Pura ini terletak di Desa Antiga Kelod, Kecamatan Manggis, Karangasem. Pura ini terletak di dataran tinggi lebih dari 200 mdpl. Sebelum mencapai Pura Luhur Andakasa, para pemedek akan menjumpai Pura-Pura Penataran dibawahnya. Pura-pura ini kemudian disebut Pura Penataran di kawasan Andakasa. Seperti Pura Tirta Mas dan Pura Pasar Agung. Pada kedua pura ini, penataan pura berdasarkan konsep Tri Mandala belum terlihat jelas antara area Nista Mandala, Madya Mandala, dan Utama Mandala.

Dengan kondisi eksisting kedua pura tersebut, ada keinginan dari pengempon pura terutama untuk kembali menata dan melengkapi fasilitas pura sehingga dapat berfungsi dengan semestinya. Oleh sebab itu dengan adanya rencana penataan kembali Pura Tirta Mas dan Pura Pasar Agung, maka diperlukan gambar masterplan dan Detail Engineering Design (DED) yang terencana dengan baik. Sehingga diharapkan dengan adanya gambar tersebut dapat membantu pengempon pura pada proses penataan selanjutnya, sekaligus bila diperlukan dapat dijadikan kelengkapan pada pengajuan proposal penggalian dana.
Tektonika Bale Daja / Bale Meten
Authors: I Wayan Darma  , Arya Bagus Mahadwijati W.,S.T.,M.T.
Published: October 2023

Bale Daja merupakan bale yang mengikuti perletakan sesuai dengan arah mata angin sesuai orientasi arah mata angin masyarakat setempat. Kaja atau daja, secara harfiah berarti Utara, namun bagi masyarakat Bali arah kiblat Kaja adalah tempat yang tinggi atau pegunugnan. Mengingat terdapat gugus pegunungan di bagian tengah Pulau Bali, maka arah Kaja bagi masyarakat Bali Utara berada di selatan, sedangkan arah Kaja bagi masyarakat Bali Selatan berada di utara. Pada jaman sekarang ini dimana hotel dan penginapan yang dibangun sudah banyak mengambil desain dari bangunan bale daja. Selain dampak positif dari segi ekonomi terdapat juga dampak negatif dari banyaknya bangunan bale daja yang digunakan sebagai desain dari penginapan. Masalah yang akan dibahas yaitu bangunan bale daja di rumah tradisional di Bali. Dikarenakan jaman yang sudah modern dan kebutuhan ekonomi yang semakin meningkat banyak penduduk Bali yang berada pada daerah yang berpotensi sebagai Desa Wisata menggunakan Bale Dajanya sebagai penginapan untuk wisatawan
KEUNIKAN ARSITEKTUR PURA DALEM SEGARA MADHU DESA PAKRAMAN JAGARAGA, SINGARAJA
Authors: Ni Luh Ugi Surya Savitri  , Desak Made Sukma Widiyani, S.T., M.T.  , Anak Agung Ayu Sri Ratih Yulianasari, S.T., M.Ars
Published: October 2023

Pada umumnya pura satu dengan lainnya akan memiliki ciri khas ataupun keunikan yang berbeda. Seperti contohnya salah satu pura yang berlokasi di Buleleng. Pura Dalem Segara Madhu Desa Jagaraga tersebut salah satu pura yang menjadi destinasi pariwisata bagi turis lokal atau mancanegara. Keunikan Arsitektur dari pura ini memiliki daya tarik bagi para wisatawan. Tulisan ini mengungkapkan kekayaan dan keunikan arsitektur maupun sejarah yang terdapat pada Pura Dalem Segara Madhu tersebut. Metode yang digunakan pada penelitian ini adalah metode kualitatif, sebagai prosedur riset yang memanfaatkan data deskriptif, berupa kata-kata tertulis atau lisan dari orang-orang dan pelaku yang dapat diamati. Pura Dalem Segara Madhu tersebut menjadi saksi Perang Jagaraga yang terjadi pada tahu 1848-1849. Pura Dalem Segara Madhu juga memiliki keunikan di ragam hiasnya, seperti ragam hias yang cenderung meruncing ciri khas ukiran Buleleng atau ukiran dengan gaya Bali Utara berupa tumbuhan merambat dan motif bunga. Terdapat pula relief yang menggambarkan kapal laut yang diserang monster laut, orang yang mengendarai mobil. Keunikan tersebut menjadi daya tarik wisata bagi masyarakat untuk berkunjung ke Pura Dalem Segara Madhu Desa Jagaraga.  Relief yang terdapat di Pura Dalem Segara Madhu menceritakan kehidupan masyarakat Bali saat penjajahan Belanda. Keunikan tersebut yang menjadi sebuah identitas yang mecirikan Pura Dalem Segara Madhu