bluuebunny/crossref_metadata_2025 huggingface dataset:
Cp2ZrCl2: AN EFFICIENT CATALYST FOR MULTICOMPONENT SYNTHESIS OF CAROTENOID DEHYDROSQUALENE SYNTHASE INHIBITING PYRANO[2,3-d]PYRIMIDINEDIONES
Authors: D SONAWANE BABASAHEB , D SONAWANE VIKAS D , D SONAWANE KAILAS , J DHANAVADE MARUTI D , B AWARE CHETAN , K AWATE SHARAD , V PATIL SURESH
Published: October 2019

Objectives: The present protocol deals with zirconocene dichloride (Cp2ZrCl2) catalyzed synthesis of pyrano[2,3-d]pyrimidinediones through one-pot multicomponent reactions of aromatic aldehydes with malononitrile and barbituric acid at ambient temperature. All the synthesized compounds were characterized and evaluated for antibacterial, antifungal, and antioxidant activities. Furthermore, a molecular docking was carried out to reveal the atomic insights between synthesized compounds and carotenoid dehydrosqualene synthase (PDB ID: 3ACX).

Methods: All the synthesized compounds were evaluated for their in vitro antimicrobial activity by diffusion method. Antioxidant activities such as 1,1-diphenyl-2-picrylhydrazyl and radical scavenging activity. A mixture of barbituric acid 1 (1 mmol), malononitrile 2 (1 mmol), benzaldehyde 3a (1 mmol), ethanol (5 mL), and Cp2ZrCl2 (5 mol %) was stirred at ambient temperature for specified time. After completion of reaction as indicated by thin-layer chromatography, the obtained crude product was filtered and purified by column chromatography on silica gel (Merck, 60–120 mesh) using ethyl acetate:pet. ether to afford pure product which was then characterized by spectroscopic methods such by FTIR, nuclear magnetic resonance (1H NMR), 13C NMR, and mass spectroscopy.

Results: All the synthesized pyrano[2,3-d]pyrimidinediones were characterized by spectroscopic analysis. The results revealed that pyrano[2,3-d] pyrimidinediones (4 a-k) displayed the zone of inhibition in the range of 3–13 mm. The most active compound 4b displayed largest zone of inhibition of 13 mm for Escherichia coli (NCIM-2832) and 9 mm for Bacillus subtilis (NCIM-2635). The antifungal and antioxidant activity of all synthesized pyrano[2,3-d]pyrimidinediones (4a-k) showed moderate to good activity. Molecular docking studies suggest that pyrano[2,3-d]pyrimidinediones might inhibit the carotenoid dehydrosqualene synthase activity.

Conclusion: All the synthesized pyrano[2,3-d]pyrimidinediones display moderate to good antibacterial, antifungal, and antioxidant activity. This molecular docking studies supported that pyrano[2,3-d]pyrimidinediones might inhibit the carotenoid dehydrosqualene synthase (PDB ID: 3ACX).
EVALUATION OF ANTIMICROBIAL AND ANALGESIC ACTIVITY OF DIPLOCYCLOS PALMATUS FRUITS ON ALBINO MICE
Authors: Kishan J Ram , ZEEYAUDDIN KHAJA , P VENKANNA , VEMULA SATEESH KUMAR
Published: October 2019

Objective: The present study is preplanned to assess the antimicrobial and analgesic activity of the collected plants of Diplocyclos palmatus from Moinabad, Ranga Reddy, Telangana.

Methods: In this study, D. palmatus fruits were used to gain the ethanolic extract and were tested for the phytochemical screening, antimicrobial activity using agar diffusion method against Gram-negative bacteria (Escherichia coli) and Gram-positive (Bacillus) and to compare its effect with the marketed standard streptomycin, ciprofloxacin, and analgesic activity of plant was performed by tail clip, tails immersion, and radiant heat method.

Results: The maximum zone of inhibition is shown in the Gram-negative bacteria (E. coli) compared to standard and control. The ethanolic extract of D. palmatus fruits was shown analgesic activity and it was found to be more remarkable when compared to the standard aspirin and control. From the results of three different methods at different dose of ethanolic extract (100 mg/kg, 200 mg/kg, 400 mg/kg followed by 0–5 min interval up to 30 min), tail immersion method at 200 mg/kg dose of the D. palmatus fruits extract was achieved good results i.e., in 10 min (11.4 ± 1.93) and 15 min (13.4 ± 1.63). In tail clip method, 400 mg/kg dose is in 10 min (11 ± 1.67) and 15 min (10 ± 0.707) achieved best output, while same thing radiant heat method 200 mg/kg dose of the D. palmatus fruits extract is in 10 min (11.3 ± 1.67) and 15 min (14 ± 1.82) achieved outstanding results.

Conclusion: The analgesic and antimicrobial activity of ethanolic extract of D. palmatus fruits are more significant compared to the other part of D. palmatus. Hence, the study concludes that the plant is having both analgesic and antimicrobial activity, and therefore, it can be used for various therapeutic purposes and further analysis.
ISOLATION AND HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY ANALYSIS OF CONDITIONAL AMINO ACIDS FROM THE FRESH LEAVES OF ALTERNANTHERA SESSILIS
Authors: S SWARNAKUMARI , S Mohan , VE IDA CHRISTI , S ABINAYA , S KALAIVANI
Published: October 2019

Objective: The objective of the study was to isolate the conditional amino acids present in the fresh leaves extracts of Alternanthera sessilis and compare the isolated amino acids with amino acid standards.

Method: The fresh plant material was used for extraction. For the extracted sample solution, paper chromatography and high-performance thin-layer chromatography (HPTLC) fingerprinting analysis were then carried out.

Results: Since A. sessilis is rich in protein, various amino acids have been isolated in aggregates and paper chromatography has been performed. Amino acids were separated and identified using trial and error method. Cysteine, glycine, aspartic acid, and proline are the standard amino acids used for comparing with the isolated amino acids by HPTLC fingerprint analysis, which gives an idea for the authentication of the plant, its constituents and also provides a parameter for quality control.

Conclusion: The results scientifically validate the use of A. sessilis in the traditional medicine and also as a food.
INSULIN SECRETAGOGUE EFFECT OF ROOTS OF RAVENALA MADAGASCARIENSIS SONN. - AN IN VITRO STUDY
Authors: PRIYADARSINI S SAKTHI , PR KUMAR , ANAND ABHISHEK , B DEVENDIRAN , S KADIYAM VENKAT , PADMANABH ROY RICHIE
Published: October 2019

Objective: The objective of this study was to establish the cytotoxicity profile and to evaluate the insulin secretagogue effect of ethanolic root extract of Ravenala madagascariensis Sonn.

Methods: The cell viability of rat insulinoma 5F (RIN5F) cell lines over the treatment of plant extract was assessed by 3-(4,5-dimethyl-2-thiazolyl)- 2,5-diphenyltetrazolium bromide assay. The insulin-releasing effect was evaluated by insulin secretion assay over RIN5F cell lines by enzyme-linked immunosorbent assay.

Results: The ethanolic extract of the roots of R. madagascariensis Sonn. showed negligible cytotoxicity at 20–40 μg/ml, and hence, concentrations up to 40 μg/ml were used in insulin secretion assay. The ethanolic root extract at 20 and 40 μg/ml significantly (p<0.05 compared to control) stimulated the insulin release in a dose-dependent manner even in the presence of glucose at lower and higher concentrations (5 and 10 mM).

Conclusion: Thus, our results validate its traditional claim in the treatment of diabetes by stimulating the secretion of insulin, thereby suggesting a possible mechanism of its antidiabetic effect.
HYDROALCOHOLIC EXTRACT OF SWERTIA CHIRATA AND SWERTIA CORDATA ATTENUATES HYPOXIA-MEDIATED MEMORY DYSFUNCTION BY IMPROVING NEURONAL SURVIVAL IN WISTAR RATS
Authors: KAUSHAL KRITIKA , SINGH HARVINDER , KANT ANIL
Published: October 2019

Objective: Swertia chirata and Swertia cordata have been used in traditional and folk medicines to treat several mental disorders. However, the mechanistic and experimental justification to its traditional use is lacking. The present study was aimed to investigate the neuromodulatory potential of S. chirata and S. cordata during hypoxia-induced neuronal damage in Wistar rats and to determine the underlying mechanism.

Methods: Animals were divided into six groups (n=5). Hypoxia was inflicted by subjecting animals to the atmosphere having 10% O2 for 3 days. Animals were administered 100 mg/kg hydroalcoholic extract of S. chirata and S. cordata orally once daily for 7 days, after which motor coordination (Rotarod test) and memory functions (active avoidance test and passive avoidance test) were evaluated. Animals were sacrificed and biochemical investigations for oxidative stress and histopathology were performed.

Results: Subjecting animals to hypoxia resulted in marked memory dysfunction, and extract treatments improved memory functions in active avoidance and passive avoidance task. Hypoxiainduced the marked oxidative stress as indicated by the significantly elevated reactive oxygen species and lipid peroxidation and depleted catalase and glutathione levels in the hippocampus. S. chirata and S. cordata treatment alleviated oxidative stress in the hippocampus region of the brain. Brain histopathology confirmed that hypoxia resulted in significant neuronal damage and extract treatment efficiently rescued neurons from hypoxic damage. Overall, S. chirata extract treatment was observed to have better neuromodulatory effect than S. cordata during hypoxia.

Conclusion: Hypoxia induced memory dysfunction by inflicting neuronal damage and oxidative stress in the hippocampus region of the brain. The hydroalcoholic extract of S. chirata and S. cordata improved memory functions in hypoxic animals by alleviating hippocampal oxidative stress and by improving neuronal morphology and survival.
CAROTID ARTERY INTIMA-MEDIA THICKNESS AND 10-YEAR RISK OF HEART DISEASE IN DIABETIC PATIENTS: A COMPARATIVE STUDY
Authors: MUGADA VINODKUMAR , KOLAKOTA RAJ KIRAN
Published: October 2019

Objective: The aim of the present study was to assess the factors affecting carotid artery intima-media thickness (CIMT) and 10-year risk of heart disease in diabetic patients classified according to CIMT.

Methods: This was an analytical cross-sectional study conducted on 92 patients for 1 year. 10-year risk of heart disease was calculated using the American College of Cardiology/American Heart Association Guideline on the Assessment of Cardiovascular Risk. Based on CIMT, the subjects were classified into two groups. Group 1 contains subjects with CIMT <0.9 and Group 2 contains subjects with CIMT ≥0.9. The Mann–Whitney U-test, Pearson’s correlation, and descriptive statistics were used to compare and describe the data. The level of statistical significance was taken at p<0.05.

Results: Patients with 51–60 years of age group are high in number. Males were predominantly high than their counterparts. There is a statistically significant association between total cholesterol (p=0.001), high-density lipoproteins (p=0.000), low-density lipoproteins (p=0.001), postprandial blood sugar (p=0.000), and hemoglobin 1Ac (p=0.035) with CIMT. The mean 10-year risk of heart disease in Groups 1 and 2 is 13.13±15.40 and 23.63±17.57, respectively. There is statistically highly significant association (p=0.000) of 10-year risk of heart disease between two groups. There is a positive correlation (r=0.45, p<0.0001) between CIMT and risk of heart disease.

Conclusion: Our study found that greater the CIMT, greater the risk of the heart of disease.
DEVELOPMENT OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF DIACEREIN FOR ENHANCED DISSOLUTION RATE
Authors: TAMBOLI JAMEER A , K MOHITE SHRINIVAS
Published: October 2019

Objective: The objective of the present study was to develop solid self-microemulsifying drug delivery system (S-SMEDDS) of diacerein (DCN) for enhancement of dissolution rate.

Methods: Three batches of liquid SMEDDS were prepared using oleic acid, Tween 80, and polyethylene glycol 200 as oil, surfactant, and cosurfactant, respectively. Microemulsion region was recognized by constructing a pseudoternary phase diagram containing a different proportion of oil, surfactant, and cosurfactant. Prepared liquid SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size, zeta potential, and viscosity. Liquid SMEDDS was then converted to S-SMEDDS by adsorption technique using Neusilin US2 as a solid carrier. Prepared S-SMEDDS was evaluated for different micromeritic properties, drug content, reconstitution properties, in vitro dissolution study, Fourier transform infrared, and scanning electron microscopy.

Results: The results showed that all batches of liquid SMEDDS were found to be thermodynamically stable. Reconstitution properties of S-SMEDDS showed spontaneous microemulsification with globule size 0.271 μm and −16.18 mV zeta potential. From the results of in vitro dissolution study, it was found that the release of DCN was significantly increased as compared with plain DCN.

Conclusion: The study concluded that dissolution rate of poorly water-soluble drug like DCN can be increased by developing S-SMEDDS formulation.
ISOLATION, OPTIMIZATION, AND ANTITUMOR ACTIVITY OF L-ASPARAGINASE EXTRACTED FROM PECTOBACTERIUM CAROTOVORUM AND SERRATIA MARCESCENS ON HUMAN BREAST ADENOCARCINOMA AND HUMAN HEPATOCELLULAR CARCINOMA CANCER CELL LINES
Authors: ABDEL-RAZIK NOHA E , EL-BAGHDADY KHALED Z , EL-SHATOURY EINAS H , G MOHAMED NAHLA
Published: October 2019

Objectives: The objective of this research was to obtain isolates capable of producing a high yield of L-asparaginase enzyme and to evaluate the antitumor activity of the purified enzyme against different cancer and normal cell lines.
Methods: Isolation of bacteria was performed by the serial dilution technique of soil samples collected from Cairo, Egypt, using modified M9 agar plates. Culture filtrates of selected isolates were quantitatively screened for L-asparaginase production using well-diffusion and direct nesslerization techniques. Factors influencing L-asparaginase activity were optimized by studying the effect of physical and nutritional conditions on the enzyme activity. The purification of L-asparaginase extracted from both the isolates was achieved using chilled acetone (−20°C), followed by gel filtration on Sephadex G-100. The anticancer activity of the purified enzyme against human breast adenocarcinoma (MCF-7), human hepatocellular carcinoma (HepGII) and homo sapiens human (WISH) cell line was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay.
Results: Two L-asparaginase producers were identified by Biolog identification system as Pectobacterium carotovorum and Serratia marcescens. Optimization increased the production of L-asparaginase to 4.835 and 5.221 U/ml for P. carotovorum and S. marcescens, respectively. L-asparaginase was extracted, purified, and tested in vitro for cytotoxic activity using 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT assay) against MCF-7, HepGII, and WISH cell line. L-asparaginase from P. carotovorum and S. marcescens was neutral to normal epithelial WISH cells. On the other hand, L-asparaginase from both isolates was cytotoxic to MCF-7 and HepGII cancer cell lines with an half maximal inhibitory concentration of 15 μg/ml and 26 μg/ml and 26 μg/ml and 25 μg/ml, respectively.
Conclusion: L-asparaginase extracted from P. carotovorum and S. marcescens showed remarkable anticancer activity. Further studies on hypersensitivity action need to be carried out to recommend the use of L-asparaginase as an alternative to commercially available preparations.
ANTI-INFLAMMATORY ACTIVITY OF NIGELLA SATIVA SILVER NANOPARTICLES: BIOCHEMICAL STUDY
Authors: KANNAYIRAM GOMATHI , A SANDHYA , S SOWMIYA , S VALARMATHI , JOSEPH DANIEL
Published: October 2019

Objective: The aim of this study is to evaluate the anti-inflammatory activity of Nigella sativa silver nanoparticles (NS AgNPs).
Methods: Fourier transform infrared analysis was used to characterize the NS AgNPs and the extract. 2,2-diphenylpicrylhydrazyl assay was done to test the antioxidant potency of NS AgNP. Furthermore, in vitro anti-inflammatory activity of the extract and the NS AgNP was determined by red blood cell (RBC) membrane stabilization assay, protein inhibition assay, and interleukin-1 (IL-1) beta assay.
Results: The NS AgNP exhibited dose-dependent antioxidant property. At the concentration 0.01 mg/ml 80% of radical was scavenged by NS AgNP. Inhibition of protein denaturation assay also suggests that NS AgNP shows the highest activity (70%) when compared with the standard drug aspirin (65%). RBC assay suggests that NS AgNP stabilizes the RBC membrane and prevents leaking. In the enzyme-linked immunosorbent assay method the NS AgNP showed better IL-1 beta inhibition activity when compared to aqueous extract.
Conclusion: From the study, it was inferred that NS AgNPs are more effective when compared to the extract. These results suggest that NS AgNP can be used to treat inflammatory disorders.
EXTRACELLULAR BIOFABRICATION OF SILVER AND GOLD NANOPARTICLES: TREASURES FROM THE ABYSSAL ZONE
Authors: RAMALINGAM NANTHAKUMAR , ROSE CHELLAN , KRISHNAN CHITRA , SANKAR SEETHALAKSHMI , KURIAN SELINA GRACE
Published: October 2019

The synthesis of nanoparticles can be accomplished by physical, chemical and biological strategies. Since this has become an expanding area of research in the field of medical sciences and Technology, owing to its potential applications, the need for eco-friendly, non-toxic and economical methods of synthesis have arisen. Biosynthesis of nanoparticles have become the main field of research as it is time efficient, cost effective, less toxic and has abundant resource. This review emphasizes on the biosynthesis of gold (Au) and silver nanoparticles (AgNPs) using marine sources with special reference to algae, their characterisation and its applications. The characterisation of metal nanoparticles is an essential step and can be carried out by various instruments. The various pharmacological, electrical, pest management, parasitology and medical applications of these marine source induced synthesis of nanoparticles have also been portrayed in this review.Â
ANTIOXIDANT, ANTIBACTERIAL, AND ANTICANCER ACTIVITY FROM MARINE RED ALGAE GRACILARIA EDULIS.
Authors: TS HEMASUDHA , R THIRUCHELVI , P BALASHANMUGAM
Published: October 2019

Objective: The marine seaweed Gracilaria edulis was collected from Rameshwaram Mandapam coast. The main objective of G. edulis was to check about the antioxidant, antibacterial, and anticancer activity. The potential use of seaweeds is to prevent colon cancer and leukemia. The crude extract of antioxidant activity was done in methanol and aqueous extract in various concentrations using DPPH assay. The antibacterial activity was analyzed in methanol extract. The antibacterial activity was tested in Gram-positive bacteria (Staphylococcus aureus) and Gram-negative (Pseudomonas) bacteria with various concentration. The anticancer activity was tested against using the breast cancer cell line (MDA-MB231)

Methods: The antibacterial activity was checked by crude methanol extract using Gram-positive bacteria (S. aureus) and Gram-negative bacteria (Pseudomonas) with different concentrations. The antioxidant activity was determined using DPPH radical scavenging assay in various concentrations. The anticancer activity was done using 3-(4, 5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against breast cancer cell line (MDA-MB231).

Results: The antioxidant activity of marine red algae was checked using the stable DPPH radical scavenging assay. The antibacterial activity was analyzed and shows the activity of two different bacteria strain against methanol extract. The anticancer activity was done against breast cancer cell line using MTT assay.

Conclusion: Thus, the result shows that red algae G. edulis has good biological activity, and further it can be carried out in pharmaceutical, food preservatives, and cosmetic purpose.
CORRELATIONS OF DEOXYRIBONUCLEIC ACID METHYLATION, HISTONE ACETYLATION, AND MICRORNA‑320 WITH SORBITOL DEHYDROGENASE IN DIABETIC RETINOPATHY
Authors: AMIN RAMZI , HILMANTO DANY , KARTASASMITA ARIEF S. , PERMANA HIKMAT
Published: October 2019

Objective: Prolonged and persistent hyperglycemia in diabetes mellitus (DM) leads to a variety of vascular complications, including the retinal disorder of diabetic retinopathy (DR). The mechanism of fructose formation of sorbitol assisted by sorbitol dehydrogenase (SDH) causing the loss of pericytes in the blood vessel is affected by epigenetic work comprised of deoxyribonucleic acid (DNA) methylation, histone acetylation, and microRNA‑320. This study aimed to determine the correlation of DNA methylation, histone acetylation, and microRNA‑320 with SDH in DR.

Methods: This case–control study was conducted at a tertiary general hospital from July 2014 to June 2016. Study subjects were type 2 DM patients with and without DR, over 40 years old, suffered from DM for > 10 years. DNA methylation, histone acetylation, and microRNA‑320 were examined by real‑time quantitative polymerase chain reaction, while SDH level examination was carried out by enzyme‑linked immunosorbent assay. Analyses were performed with independent t‑test, Mann–Whitney, Spearman correlation, and multiple linear regression.

Results: With respect to SDH, DNA methylation showed no significant correlation so as histone acetylation, in contrary to microRNA‑320 with a very strong negative correlation (r=−0.968, P < 0.005).

Conclusion: MicroRNA‑320 was correlated to SDH in a manner of protective properties against the occurrence of DR. Involvement of DNA methylation and histone acetylation was perceptible in influencing SDH enzyme despite their insignificance if they took place individually.
Kant y el conocimiento de sí mismo
Authors: Lazos Efraín
Published: October 2019

The paper takes up J. McDowell’s claim in Mind and World that the lack of a serious notion of second nature is an obstacle to an effective response by Kant to the Cartesian view of the self. A reconstruction of the Cartesian model of the mind is offered, as well as an analysis of key passages in the Critique of Pure Reason and P.F. Strawson ́s reception of them, to the effect that there is a sense in which Kant may successfully do away with Cartesian temptations without recourse to the abovementioned notion.
Nietzche, Wagner y el Renacimiento italiano
Authors: Campioni Giuliano
Published: October 2019

The purpose of this essay is to redefine Nietzsche’s relationship with the Renaissance, beyond some outstanding and terrible simplifications, and the literary and aesthetic creations of myths focused on the constellation superman, Renaissance-will-of-power, and Antichrist. Richard Wagner strongly conditions Nietzsche’s ideas with his valuations of the Renaissance. There is, in the young author of The Birth of Tragedy, a strong diffidence on the footsteps of the German ideology of the musician and of his rooted aversion to the Renaissance. The Italian Opera seems to be a false revival of the Greek Opera in its paradigmatic model of the artifice, and of the luxury of a selfish aristocracy, far from the feeling of the Volk. As a philologist and a promoter of a revival of the Greek world in Germany, Nietzsche had in the Italian Renaissance a necessary model of comparison. After an initial hostility followed a freer and more open evaluation that can be read in his posthumous documents, regardig the complexity of its experimental movement. The influence of Burckhardt in particular shows a progressive turning point, considerable for bringing a new definition of his relationship with the musician. The essay pauses on Nietzsche’s notes to the lessons dedicated to The Discovery of the Antiquity among the Italians, which turned out to be a mosaic of quotations from The Civilization of the Renaissance in Italy. It is certainly the most important document, largely ignored throughout history, of the close relationship between Nietzsche and Burckhardt. On the search for complexity and plurality that characterizes the superior culture, Nietzsche discovers and enhances the value of the Latin Renaissance in direct opposition to the German Renaissance impressed by Wagner’s illusion. With Burckhardt, he discovers the individual man and the poet-philologist, a prototype of the free spirit, putting into practice the detachment from the German myth of the Volk and opening the way to the culture of Romanticism.
El "sistema de la libertad" en el pensamiento de Schelling
Authors: Álvarez Fernando Pérez-Borbujo
Published: October 2019

This essay articulates an interpretation of Schelling’s philosophy that is centered on the problem of human liberty: how is it possible that an empirical I exists, from whom trascendental liberty might be pronounced? How can it be that from the absolute, in which liberty and necessity coincide, an empiric I arises in which liberty and necessity appear divided? Liberty is not an attribute of a human faculty, the will, but the being of man itself. From this point, the author demonstrates that, for Schelling, the system does not deny liberty but, paradoxically, liberty tends to give itself a systematic form and that its philosophical system is, therefore, a system of liberty.
La conquista de la fortuna
Authors: Hermosa Andújar Antonio
Published: October 2019

In this work the author holds the thesis that with Maquiavelo, in accordance with Tucidides, the complete humanization of history and human life arose. Man has become the complete owner of his destiny when conquering fortune by virtù, that is, the entirety of social forces, concrete or diffuse, that oppose to the exercise of his will. It is only nature that remains as a region still inaccessible to human will. This is the reason why in Maquiavelo the concepts which should organize the explanation of human behavior are not, as considered until now, virtù/fortune but virtù/nature. Even though, there are two antagonic limits to the emancipatory virtuos action: on the one hand, its still nondemocratic condition, since only the Prince is capable of such virtù. On the other, the political liberty, something that in principle appears external to the subject, but once known he won´t forget ever, that is, political liberty becomes a constitutive feature of the human being at which every virtuos action of the Prince directed to extirpate it, fails.
Problemas de la recepción de la tercera Crítica de Kant
Authors: Escalante Evodio
Published: October 2019

The history of reception of Kant’s Critique of Judgement is surrounded by equivocal and oblique readings that at the end result fruitful and can’t be denied by simply declaring them “erroneous”. This article analyzes some of these “misunderstandings” originated by the rigor of this book, which effects can be acquainted even in some branches of contemporary art as well as of the “posmodern” thought. It is also pointed the way in which the writing of The Critique of Judgement supposes a significant change in Kant’s original conceptions in the way they were exposed in The Critique of Pure Reason.
El último kantiano
Authors: Tovar González Leonardo
Published: October 2019

According to Foucault, Kant established the mission of philosophizing as ontology of the present, however when applying the lessons to our era everything seems to indicate that we should abandon his announcements full of hope on the gradual moral and political illustration of human kind and conclude, with Benjamin, after the memory of the defeated that “every act of civilization is an act of barbarity”. Or perhaps the distance between the rationalist scatology of the philosopher of Könisgsberg and the agonistic memorial of the thinker of Berlin is not so large, since in both cases they intend to replevy human dignity, in Kant for the sake of making it possible, in Benjamin for the indignity not to be repeated.
La ciencia-filosofía en Eduardo Nicol
Authors: González Valenzuela Juliana
Published: October 2019

This paper analyses the indissoluble integration between Science and Philosophy from classic Greek to the Modernity. Juliana González, working in a deep and renewed form about thinker Eduardo Nicol, gices reasons fir the continued dialogue bewteen Sciences and Humanities, in the context of a new Humanism that increases the creative power of the human being.
Ramón Xirau: la verdad en la poesía y la pertinencia filosófica de las imágenes
Authors: Cabrera Isabel
Published: October 2019

Xirau is a philosopher who is always seeking the union between philosophical arguments and poetical images. He is seduced by the eloquence and the persuasiveness of images. In this paper I briefly analyze four examples, two from literature to philosophy (John of the Cross and Jorge Luis Borges), and two from philosophy to literature (Wittgenstein and Nietzsche). All of them show the way Xirau finds metaphysics behind poetry, and poetry behind metaphysics.
Adolfo Sánchez Vázquez y el humanismo iberoamericano
Authors: Gómez Ambrosio Velasco
Published: October 2019

In this paper the author reviews the creativity in the work of Adolfo Sánchez Vázquez, and the context of this work. Velasco goes through the capital contributions of the exiled thinker and emphasizes his connection with Humanism.
Nuevas perspectivas de la hermenéutica en México
Authors: Oliva Carlos
Published: October 2019

The author presents a critique and synthesis of three Mexican hermeneuters: Mariflor Aguilar; Mauricio Beuchot and Ambrosio Velasco, in order to emphasize the principal features of the contemporary hermeneutics developed in Mexico.
Lucas Alamán. La Conquista de México y el origen de una nueva nación
Authors: Patiño Palafox Luis Aarón
Published: October 2019

Century XIX was the complex period of foundation of Mexico after to have been part of Spain by three centuries. The optics around the newhispanic period was one of main the differences between members of just arisen Mexican nation, and in this way the conquest of Mexico became a subject from great relevance, reason why negative and positive visions occurred on the New Spain. The basic problem was the one to show on the other, which had been the origin of Mexico, that would be seen, on the one hand, like a complete breaking with Spain and the tendency to a modern and liberal way for the country, and like a relative continuity of the newhispanic traditions in questions like the government, the religion and the society. Within the personages who influenced more at this time is Lucas Alamán, that is well-known, mainly, like the father of Mexican conservatism and by his monumental Historia de Méjico, although also he was author of Disertaciones sobre la historia de México, in which a thought nearer the philosophy of history is seen and in which tried to write complete the history of Mexico from the conquest to its time, defending that the conquest had been the origin the nation, presenting/displaying a positive vision of that event and the newhispanic. It will be this part of the historical and political thought of Alamán which will be analyzed in this work.
PENINGKATAN HASIL BELAJAR MENYUSUN TEKS LAPORAN HASIL OBSERVASI PADA PESERTA DIDIK KELAS X SMAN 7 MALANG DENGAN MODEL PEMBELAJARAN INTEGRATIF
Authors: M.Si Gigit Mujianto,
Published: October 2019

Untuk meningkatkan motivasi belajar peserta didik dalam pelajaran Bahasa Indonesia perlu adanya model pembelajaran yang diminati peserta didik. Salah satu model pembelajaran yang diyakini dapat meningkatan motivasi belajar peserta didik adalah Model Pembelajaran Integratif. Berdasarkan Siklus I dan Siklus II yang telah dilaksanakan, penerapan model pembelajaran integratif dalam pembelajaran Bahasa Indonesia dapat terlaksana dengan baik. Hal tersebut dapat dilihat dari lembar pengamatan pelaksanaan penelitian dan aktivitas peserta didik saat mengikuti proses pembelajaran. Hasil belajar peserta didik pada materi menyusun teks laporan hasil observasi mengalami peningkatan, dilihat dari persentase hasil belajar yang meningkat dari ketuntasan peserta didik sebesar 85% pada Siklus I menjadi 97% pada Siklus II. Hal ini membuktikan bahwa penerapan model pembelajaran integratif dapat meningkatkan kemampuan peserta didikdalam meningkatkan hasil belajar peserta didik.
Science stories as culture: experience, identity, narrative and emotion in public communication of science
Authors: Davies Sarah Rachael , Halpern Megan , Horst Maja , Kirby David , Lewenstein Bruce
Published: October 2019

The last three decades have seen extensive reflection concerning how science communication should be modelled and understood. In this essay we propose the value of a cultural approach to science communication — one that frames it primarily as a process of meaning-making. We outline the conceptual basis for this view of culture, drawing on cultural theory to suggest that it is valuable to see science communication as one aspect of (popular) culture, as storytelling or narrative, as ritual, and as collective meaning-making. We then explore four possible ways that a cultural approach might proceed: by mobilising ideas about experience; by framing science communication through identity work; by focusing on fiction; and by paying attention to emotion. We therefore present a view of science communication as always entangled within, and itself shaping, cultural stories and meanings. We close by suggesting that one benefit of this approach is to move beyond debates concerning ‘deficit or dialogue’ as the key frame for public communication of science.
Storytelling: the soul of science communication
Authors: Joubert Marina , Davis Lloyd , Metcalfe Jennifer
Published: October 2019

There is a renewed interest amongst science communication practitioners and scholars to explore the potential of storytelling in public communication of science, including to understand how science storytelling functions (or could fail) in different contexts. Drawing from storytelling as the core theme of the 2018 conference of the Public Communication of Science and Technology (PCST) Network, we present a selection of papers, essays and practice insights that offer diverse perspectives. Some contributions focus on the cultural and structural qualities of science stories and its key success factors, while others explore new formats, platforms and collaborators in science storytelling activities.
A SYSTEMATIC REVIEW OF DIAGNOSIS AND TREATMENT OPTIONS FOR TINEA IMBRICATA
Authors: ABDULAZEEM AL-BASSAM RANA , SALEM AL AFARI BASMAH , HASSAN MOHAMED SALEM MANAL
Published: October 2019

Tinea imbricata is a cutaneous fungal disease and sometimes called (Tokelau). The causative agent is a dermatophyte known as Trichophyton concentricum. It is an endemic in developing countries particularly in South Pacific, India, Central and South America, as well as Mexico. It is generally observed in people with poor living conditions and poor personal hygiene. Predisposing factors are hot weather, humidity, and host immunity in addition to genetic factors. The patients usually presented with concentric or lamellar skin lesions. The aim of this review is to highlight important information about microbial, clinical and therapeutic aspects of tinea imbricta. In this review, we search the literature to identify articles talking different aspects of tinea imbricta. The electronic search was performed in four databases to identify eligible articles in the literature. Electronic databases were searched including MEDLINE and EMBASE using PubMed search engine. In addition, Cochrane library and ovid was searched. The titles and abstracts of the resulted articles were screened to identify eligible studies. Based on the primary screening results the irrelevant studies, duplicated and reviews were excluded. Tinea imbricta is found to be endemic in 3 main geographical regions, Southwest Pacific, Southeast Asia, and Central and South America. There is an autosomal recessive genetic factor which increases the vulnerability to tinea imbricta infection. The levels of both general and specific IgE class antibodies were higher than normal values. Usual clinical findings of tinea imbricta are multiple annular, concentric, squamous sores and may be associated with erythema. The infection usually starts in young people on the facial region and disseminate to the trunk, arms or legs.The eradication of the disease has not been possible yet, thus preventative procedures should be adopted as a strategy of disease control.
Bovine Respiratory Disease Complex (BRDC): A review of lung lesions and reducing of quality of carcasses
Authors: Kurcubic Vladimir , Djokovic Radojica , Ilic Zoran , Vaskovic Nikola , Petrovic Milos
Published: October 2019

Bovine respiratory disease complex (BRDC) is the biggest health problem of
the cattle industry globally due to the high prevalence and economic
consequences which arise due to numerous reasons. Huge economic losses are
most often attributed to high morbidity and mortality, reduction of Average
Daily Gain (ADG) and food utilization, weight loss, lower quality of
carcasses and comprehensive measures of prophylaxis and therapy. BRDC
commonly observed throughout the feedlot phase due to the stress factors.
Predisposing factors divided didactic on environmental (inclement weather
conditions, inadequate humidity and dust), host factors (age, sex, race,
genetics, immune status) and stressful management practices (transportation,
nutritional stress, metabolic disease, high density of animals, handling,
castration, dehorning). In complex etiopathogenesis, in addition to the
aforementioned predisposing factors, numerous viral and bacterial agents are
involved. Gross lung lesions are most commonly observed in cattle slaughter
or autopsies (visible to the naked eye) occur as a result of pneumonia. It
is the result of an infection by the bovine respiratory syncytial virus
(BRSV), parainfluenza virus type 3 (PI3V), bovine herpes virus type 1
(BoHV1) and bovine viral diarrhea virus (BVDV) alone or in combination with
one another, as well the common bacterial pathogens Mannheimia haemolytica,
Pasteurella multocida, Histophilus somni and Micrococcus spp. Numerous
studies have pointed to the detrimental effects on performance and carcass
characteristics.
Effect of non-genetic factors on longevity traits in Simmental cows
Authors: Petrovic Milun , Rakonjac Simeon , Bogdanovic Vladan , Bogosavljevic-Boskovic Snezana , Djokovic Radojica , Djedovic Radica , Petrovic Milos
Published: October 2019

The effects of fixed non-genetic factors (farm, season of birth, year of
birth, total number of lactations) and a continuous non-genetic factor (age
at first conception) on the expression and variability of longevity traits
such as age at culling, length of productive life, days in milk and cow
efficiency index were investigated in 2548 Simmental cows in three farming
areas. Based on the model used for the analysis of the effects of
non-genetic factors, including the environment and cow age at first
conception, on the expression and variability of longevity traits, the
overall means for age at culling, length of productive life, days in milk
and cow efficiency index were 2445.21?17.49 days, 1562.55?17.71 days,
1094.17?12.28 days and 58.68?0.32%, respectively. The effect of farming
area, year of birth and lactation group on longevity traits was very
significant (P<0.01), whereas the effect of season of birth was significant
(P<0.05). Age at first conception had a highly significant (P<0.01) effect
on age at culling, length of productive life and cow efficiency index, and
no significant effect on days in milk (P>0.05). Based on the model used, the
coefficients of determination (R2) were very significant (P<0.01) for all
longevity traits, and ranged from 0.898 for age at culling to 0.959 for days
in milk.
Random Forest Algorithm for Prediction of Precipitation
Authors: Primajaya Aji , Sari Betha Nurina
Published: October 2019

Predicting rainfall needs to be done as one of such effort to anticipate water flooding. One of the algorithm that can be used to predict rainfall is random forest. The porpose of the research is to create a model by implementing random forest algorithm. The research method consist of four steps: data collection, data processing, random forest implementation, analysis. Random forest implementation with using training set resulted model that has accurracy 71,09%, precision 0.75, recall 0.85, f-measure 0.79, kappa statistic 0.33, MAE 0.35, RMSE 0.46, ROC Area 0.78. Implementation of random forest algorithm with 10-fold cross validation resulted the output with accurracy 99.45%, precision 0.99, recall 0.99, f-measure 0.99, kappa statistic 0.99, MAE 0,09, RMSE 0.14, ROC area 1.
Implementation of Backpropagation Neural Network to Detect Suspected Lung Disease
Authors: Syafria Fadhilah , Iqbal Boni , Budianita Elvia , Afrianty Iis
Published: October 2019

Many People were less concerned with lung health, it caused people identified as suffering from lung diseases. Early symptoms that often appear  was cough that took a long time and could be the beginning of more severe disease. Therefore it was necessary to create application that could detect suspected person contracted lung disease. The applications were made by using artificial neural network with Backpropagation with initial input data, symptoms by patients of lung diseases. The symptoms were 22, and kind of lung diseases as a diagnosis were asthma, pneumonia, pulmonary tuberculosis and lung cancer. It used medical records of lung disease as much as 110 data. Network training uses 3 different architectures [input neurons ; hidden neurons ; output neurons], liked [22; 22 ; 2], [22 ; 33 ; 2] and [22 ; 43 ; 2]. Testing with 2 training data sharing and test data, namely comparison 90:10 and 80:20. The Parameters values were used namely learning rate 0.1, 0.3, 0.5, 0.7 and 0.9. The number of epoch was used, that is 15 epoch, 25 epoch and 35 epoch. Based on the tests performed, it was obtained an accuracy system on the 90:10 data comparison of 82% and the 80:20 data ratio of 82% as well. Thus, backpropagation method could be applied in detecting suspected lung diseases.
The Application Of Fuzzy K-Nearest Neighbour Methods for A Student Graduation Rate
Authors: Ahmad Imam , Sulistiani Heni , Saputra Hendrik
Published: October 2019

The absence of prediction system that can provide prediction analysis on the graduation rate of students becomes the reason for the research on the prediction of the level of graduation rate of students. Determining predictions of graduation rates of students in large numbers is not possible to do manually because it takes a long time. For that we need an algorithm that can categorize predictions of students' graduation rates in computing. The Fuzzy Method and KNN or K-Nearest Neighbor Methods are selected as the algorithm for the prediction process. In this study using 10 criteria as a material to predict students' graduation rate consisting of: NPM, Student Name, Semester 1 achievement index, Semester 2 achievement index, Semester 3 achievement index, Semester 4 achievement index, SPMB, origin SMA, Gender , and Study Period. Fuzzyfication process aims to change the value of the first semester achievement index until the fourth semester achievement index into three sets of fuzzy values are satisfactory, very satisfying, and cum laude. Make predictions to improve the quality of students and implement KNN method into prediction, where there are some attributes that have preprocess data so that obtained a value, and the value is compared with training data, so as to produce predictions of graduating students will be on time and graduating students will be late. This study produces a prediction of student pass rate and accuracy.
Desease Identification In Plant Leaf Image of Chili (Capsicum Annum (L)) Using Image Processing and Automated Colour Equalization (ACE) Algorithm
Authors: Basiroh Basiroh
Published: October 2019

The world of agriculture becomes one of the vital objects and one of the promising business prospects. To obtain optimal agricultural yield, the process of plant care and the way of planting should be really - maximal, because the main key in seeking maximum results in terms of quality and quantity. Harvest failures are the least desirable to farmers and crop failures are the number one scariest specter for cultivating farmers. Today's informatics technology has been developed in an effort to support increased yields in the agricultural sector. This study measured the level of accuracy of results ekstraksi texture and colour feature. This research method using SVM classification ( Support Vector Machine ) seeks image processing through analyzing with Automated Color Equalization (ACE). With this method the accuracy of the extraction results a combination of 80% texture features, color feature extraction, and a combination of 80% color feature texture
Frameworks Comparative study of Classification Models based on Variable Extraction Model for Status Classify of Contraception Method in Fertile Age Couples in Indonesia
Authors: Khikmah Laelatul
Published: October 2019

In terms of minimizing the risk of death in mothers the use of contraceptive methods really needs to be improved and the success of the use of contraceptive methods. This study aims to compare several popular classification models used to classify the status of the use of contraceptive methods in fertile age couples in Indonesia so that they can be used and the implementation of policies that are more impartial using the variable extraction integration method. The proposed model in this study is a comparative study of classification models include Logistic Regression (LR), k-Nearest Neighbor (k-NN), Naïve Bayes (NB), C4.5, and CART. For the purpose of testing the model, Accuracy, AUC, F-measure, Sensitivity (SN), Specificity (SP), Positive Predictive Value (PPV), and Negative Predictive Value (NPV) are used to test frameworks comparative study of classification models. Based on the experimental results, RL shows superior and stable performance compared to other methods. It can be concluded, the RL method is the right choice method to classify the status of use of contraceptive methods in couples of childbearing ages in Indonesia.
Nurses’ Knowledge Regarding FoodDrug Interaction in the Intensive Care and Emergency Hospitals
Authors: Lafi Samir Y , Kamali Aram Salih Mohammed Amin , Sharif Bayan Omar
Published: October 2019

Usually supplement is essential and fundamental components for ensure and creating the human body, also drugs seem to survey the life of each individual and ensure the wellbeing for a long life aimed most of illness, but in case nourishment sedate interaction ignored since of information shortage almost it or any reason maybe lead to futile of medicine for the patients or cause life threatening condition because of that, one of the most significant ethical point in every health care setting in the world is patient's safety;  and  the care for patients must be improved in every country to prevent complication of interaction between food and drug. The main objective of this cross-sectional study has been conducted to assess the nurses' knowledge regarding food-drug interaction (FDI) at the intensive care in both of Shar and emergency hospitals in the Slemani city, the data were collected during the period of October up to the end of December. Non-probability, (purposive sample) of 78 nurses at both hospitals, a questionnaire was designed according to literatures and books regarding FDI which contained 25 items, 8 items for demographic characteristics, and 17 items concerning FDI. The validity of the questionnaire was given to a panel of 7 experts, a pilot study was carried out to check the reliability of the questionnaire which determined through the use of stability reliability (test-retest) approach which was estimated as r = 0.81.  The data were collected through the interviewing of the study sample and analyzed through the using of the Statistical Package for Social Sciences SPSS, version 23, and analyzed through the application of descriptive and inferential statistical analysis. The findings of the present study conclude that more than half of nurses had low knowledge and none of them had high level of knowledge, also there is no significant association between the levels of knowledge with age, gender, educational level, years of experience and working place. The study suggested extends the knowledge of nurses regarding the FDI, by training courses from clinical pharmacologists.