bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of ovarian preservation versus oophorectomy on fertility outcomes in patients with endometriosis post-laparoscopic surgery: A prospective study
Authors: Zhou Jin-Jin , Yu Ke , Mao Hai-Yan , Li Cen
Published: June 2024

BACKGROUND

Endometriosis is a chronic inflammatory condition affecting a significant proportion of women of reproductive age. Although laparoscopic surgery is commonly the preferred treatment, the decision to preserve or remove the ovaries remains controversial. Previous studies have yielded inconsistent results regarding the impact of ovarian preservation vs oophorectomy on fertility outcomes and disease recurrence. This prospective study aimed to address this knowledge gap by comparing the effects of these surgical approaches on spontaneous pregnancy rates, time to pregnancy, recurrence rates, and postoperative pain in patients with endometriosis.

AIM

To compare the reproductive outcomes and recurrence rates between ovarian preservation and oophorectomy in women undergoing laparoscopic surgery for endometriosis.

METHODS

This study was conducted at a tertiary care hospital between January 2019 and December 2023. A total of 312 women aged 18 to 40 years, diagnosed with endometriosis and undergoing laparoscopic surgery, were included. The patients were categorized into the ovarian preservation group (n = 204) and the oophorectomy group (n = 108). The primary outcome measure was the achievement of spontaneous pregnancy within 24 months post-surgery. Secondary outcomes included time to spontaneous pregnancy, recurrence rates, and postoperative pain scores.

RESULTS

The ovarian preservation group exhibited a significantly higher spontaneous pregnancy rate than that in the oophorectomy group (43.6% vs 28.7%, P = 0.006). Moreover, the median time to spontaneous pregnancy was shorter in the ovarian preservation group (8.2 months vs 11.4 months, P = 0.018). Nonetheless, endometriosis recurrence was more prevalent in the ovarian preservation group (22.1% vs 11.1%, P = 0.014). The postoperative pain scores demonstrated similar improvements in both groups, with no significant differences observed. Subgroup analyses indicated that the benefit of ovarian preservation on spontaneous pregnancy rates was more evident among younger women (≤ 35 years) and those with advanced-stage endometriosis.

CONCLUSION

Ovarian preservation is associated with a high spontaneous pregnancy rate and a short time to pregnancy. However, because of the increased risk of recurrence, the decision should be based on age, fertility aspirations, and disease severity.
Primary hepatic lymphoma presenting as pyogenic liver abscess: A case report
Authors: Xu Zhi-Yang , Pan Ying , Ye Wen-Jing , Liu Jin-Liang , Wu Xue-Jie , Tang Cui-Lan
Published: June 2024

BACKGROUND

Primary hepatic lymphoma (PHL) is a lymphoproliferative disorder confined to the liver without peripheral lymph node involvement and bone marrow invasion. PHL is extremely rare in clinical practice. The etiology and pathogenesis of PHL are largely unknown. There are no common standard protocols or guidelines for the treatment of PHL.

CASE SUMMARY

We report the case of a 66-year-old man who presented with fever and abdominal pain for three weeks. Computed tomography and magnetic resonance imaging scans showed a pyogenic liver abscess. The patient underwent a right posterior hepatectomy. The surgical pathology revealed aggressive B-cell lymphoma, with a primary consideration of diffuse large B-cell lymphoma of non-germinal center origin.

CONCLUSION

This article reviews the characteristics, mechanism and treatment of PHL and provides insight into the diagnosis of PHL.
Norwegian scabies presenting as erythroderma: A case report
Authors: Chen Hai-Ju , Lu Chun-Ying , Huang Guo-Mei , Tang Lu-Lu
Published: June 2024

BACKGROUND

Norwegian scabies (NS) is a serious parasitic skin condition. Although NS is one of the causes of erythroderma, it is frequently overlooked. Therefore, it is essential to raise awareness regarding NS presenting as erythroderma.

CASE SUMMARY

We present a case of NS that persisted for more than 3 years. After following nonstandard treatment, the patient’s rash worsened and gradually progressed into erythroderma. Finally, NS was diagnosed by skin microscopy and pathology.

CONCLUSION

When patients with pruritic dermatosis have high-risk factors such as prolonged bed rest and immunodeficiency, clinicians need to enhance their awareness of NS and ensure prompt diagnosis and treatment.
Hepatoid adenocarcinoma of the lung: A case report
Authors: Mo Yi-Jun , Lin Li-Na , Tao Jing-Li , Zhang Tao , Zhang Jian-Hua
Published: June 2024

BACKGROUND

Hepatoid adenocarcinoma of the lung (HAL) is a rare type of non-small cell lung cancer (NSCLC), histologically similar to hepatocellular carcinoma. HAL has high malignancy and poor prognosis, and a better treatment plan needs further study.

CASE SUMMARY

In order to deeply understand the occurrence and development of HAL, here we report a case of HAL with extensive metastasis of alpha fetoprotein negative KRAS A146T mutation. The patient refused chemotherapy and received one course of treatment (immune checkpoint inhibitors), and died three months later due to progressive disease.

CONCLUSION

HAL is a special type of NSCLC. The surgical treatment of HAL in the limited stage can achieve long-term survival, but most of them were in the advanced stage when they were found, and the prognosis was poor, which requires multidisciplinary comprehensive treatment.
Fifteen acute retrobulbar optic neuritis associated with COVID-19: A case report and review of literature
Authors: Li Rong-Rong , Zhang Bao-Ming , Rong Su-Ran , Li Huan , Shi Peng-Fei , Wang Yun-Chang
Published: June 2024

BACKGROUND

A subtype of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is suggested to be responsible for the outbreak in Northern China since the quarantine was lifted in December 2022. The coronavirus disease 2019 virus is primarily responsible for the development of respiratory illnesses, however, it can present a plethora of symptoms affecting a myriad of body organs. This virus has been theorized to be linked to demyelinating lesions of the peripheral and central nervous system including transverse myelitis and acute retrobulbar optic neuritis (ARON). For example, magnetic resonance imaging (MRI) of the orbit and brain showed enlargement of the retrobulbar intraorbital segments of the optic nerve with high T2 signal, and no abnormalities were seen in the brain tissue. In this case series, we analyzed the connection between SARS-CoV-2 infection and the onset of ARON.

CASE SUMMARY

Fifteen patients, and a teenage boy who did not have any pre-existing ocular or demyelinating diseases suddenly experienced a loss of vision after SARS-CoV-2 infection. The patients expressed a central scotoma and a fever as the primary concern. The results of the fundus photography were found to be normal. However, the automated perimetry and MRI scans showed evidence of some typical signs. Out of the 15 patients diagnosed with ARON after SARS-CoV-2 infection, only one individual tested positive for the aquaporin-4 antibody.

CONCLUSION

Direct viral invasion of the central nervous system and an immune-related process are the two primary causes of SARS-CoV-2-related ARON.
Intracranial hypertension as the primary symptom of malignant melanoma: A case report
Authors: Xie Hai-Ting , An Ding-Hao , Wu Duo-Bin
Published: June 2024

BACKGROUND

The etiological diagnosis of intracranial hypertension is quite complicated but important in clinical practice. Some common causes are craniocerebral injury, intracranial space-occupying lesion, subarachnoid hemorrhage, and hydrocephalus. When a patient presents with intracranial hypertension, the common causes are to be considered first so that other causes would be dismissed. With the morbidity lower than 9%, neuromelanin is very rare. Common symptoms include nerve damage symptoms, epilepsy, psychiatric symptoms, and cognitive disorders.

CASE SUMMARY

We present a patient with melanoma which manifested with isolated intracranial hypertension without any other neurological signs. A 22-year-old male had repeated nausea and vomiting for 2 mo with Babinski sign (+) on both sides, nuchal rigidity, and subarachnoid hemorrhage. He had been diagnosed with melanoma and was given surgery and whole-brain radiation. Ultimately, the patient died 2 mo later.

CONCLUSION

Malignant melanoma should be taken into consideration in the differential diagnosis of intracranial hypertension.
APPLICATION OF AHP FOR THE EVALUATION OF PUBLIC POLICY IN THE ATTENTION TO THE COVID-19 PANDEMIC, THE CASE OF MEXICO
Authors: Cruz Ariadna , Cruz Hoyos Jose Manuel
Published: June 2024

This study utilizes the Analytic Hierarchy Process (AHP) to assess Mexico’s public policy response to the COVID-19 pandemic, covering the period from February 2020, when the WHO officially declared a pandemic, to February 2021, marking the commencement of extensive vaccination campaigns. It examines the impacts of the pandemic, including health crises, economic fluctuations, societal transformations, and limitations on personal freedoms. By focusing on the medical, economic, political, and social dimensions of the adopted policies, the study identifies mixed success in economic policies and deficiencies in political and social responses. Despite challenges, Mexico’s policy measures offer valuable insights and a framework for future stability and resilience against global health emergencies. The research emphasizes the importance of flexible governance and comprehensive strategies to support a resilient, inclusive, and sustainable recovery.
A Call for Change in Healthcare Governance
Authors:   Phoenix Pulmonary and Research Education Foundation, Gilbert, AZ USA, Robbins Richard
Published: June 2024

No abstract available. Article truncated after 150 words. Over the past 30-40 years many healthcare organizations have gradually shifted from a charitable, not-for-profit organization to a not-for-profit in name only business. Accompanying this shift, has been a shift in hospital governance away from a benevolent organization directed by charitable organizations such as religious organizations to businessman focused on revenue and profits. Of course, this does not mean that not-for-profit organizations are for loss. Small or modest profits are necessary to continue to operate. Accompanying this change in organizational goals from a charitable to a more business focus, has been changes in the hospital board of directors or trustees (1). The mission of a publicly traded corporation is to return economic value to their shareholders and is the primary fiduciary focus of that board. On the other hand, the mission of a not-for-profit, 501c, charitable healthcare system is to provide health services improving the well-being of the community. The …
Never Knew Better: Comment on A Call for Change in Healthcare Governance
Authors:   Mayo Clinic Arizona, Phoenix, AZ USA, Wesselius Lewis
Published: June 2024

George is telling it like it is!! It is more difficult to get this younger generation of physicians to appreciate what is being lost as they have not known a different medical care system. Some of them will still work past 5 pm, but the number is shrinking. Lewis J. Wesselius MD
The Author Replies: Comment on A Call for Change in Healthcare Governance
Authors:   Phoenix Pulmonary and Research Education Foundation, Gilbert, AZ USA, Robbins Richard
Published: June 2024

We are all in agreement. It is most disappointing that CMS has gone out of their way to increase hospital reimbursement at the expense of independent physicians, at least in part. Dr. Parides implies that independent physicians could be good for price control benefiting patients. Dr. Wesselius points out that younger physicians have really never known a different system and so their compliance with the status quo is not surprising. Richard A. Robbins MD
Solidarity, marginalised groups, and COVID-19 lockdowns: censoriousness and penal exceptionalism in Norwegian and Danish prisons during the pandemic
Authors: Lundeberg Ingrid Rindal , Smith Peter Scharff
Published: June 2024

Some of the most marginalised and exposed populations during the COVID-19 pandemic have been those incarcerated in penal institutions. In the present article we compare how Norway and Denmark handled the pandemic in their prison systems and analyse these efforts through the lens of how the authorities tried to invoke specific national cultures of social solidarity during the crisis. In both countries we find that increased isolation, inactivity, lack of information, and loss of trust and contact with the outside world aggravated the prison experience. However, in Norway a bigger effort was made, compared to Denmark, to lower the prison population, as well as to create possibilities for maintaining contact with friends and families through video-visits. We then analyse the pandemic prison policies in the context of how both governments through very specific national terminologies appealed to an alleged community spirit. We examine the role and situation of prisoners in connection with these national and cultural projects of social solidarity, and find that in several cases prisoners reacted to the restrictive pandemic regimes by displaying a censorious attitude towards prison staff and authorities much in the manner originally described by Thomas Mathiesen (1965). Prisoners, in other words, held the authorities accountable to their call for community spirit and the values of social solidarity they claimed to represent. This also raises a question concerning the degree to which Danish and Norwegian policies and practices live up to the notion of Nordic penal exceptionalism, or whether the crisis unveiled different penal values.
Epigraphy, Image, and Material: The Strategic Power of the Word “And” on Byzantine Uterine Amulets
Authors: Tuerk-Stonberg Jacquelyn , Bardzik Jordan
Published: June 2024

Abstract: In the context of social taboos excluding bleeding women from church spaces, a Byzantine uterine amulet references the gospel story of the healing of the bleeding woman for those needing alternative means for aid. The word “and” begins its Greek inscription. This seemingly insignificant detail signals a resourceful and local application of authoritative tradition, rather than a rote or mistaken reproduction of the gospel text. The amulet’s specific use of “and” contributes in multiple ways to the amulet’s authority through its materiality, recitation, repetition, and embodiment. The amulet repackages the healing of the bleeding woman within its own text, images, and material, bringing new authority parallel to – and even in place of – church access. This essay explores the epigraphic grammatical peculiarity of beginning with “and” as an intentional, meaningful transformation of gospel rhetoric into power for the individual, with implications for a niche epigraphic tradition on this and other uterine amulets.
Physical processes of mirror reversal based on the real image of the optical system
Authors: Tanaka Junichi
Published: June 2024

All explanations for the mirror reversal phenomenon thus far before the author’s work have been based on the geometric illustration of plane symmetry, whether or not the explainer thinks the illustration is based on the optical principle. However, optically, those illustrations are based on the virtual image, and such situations as the plane symmetry can also be substantialized by using real objects of an enantiomorphic pair, such as right and left hands, without using optical explanation. Thus, only such an illustration of the plane symmetry does not represent the optical mechanism of the mirror reversal phenomenon perfectly. Another lack of understanding in explanations thus far is that directional notions such as top-bottom, front-back, and right-left are not geometric, so such directional notions cannot be used in strictly explaining physical processes. This time, I analyzed the problem based on the real image formed in a camera system as a substitute for the human eye, utilizing the Cartesian coordinate system. Thus, the study clarified the physical process of the mirror reversal phenomenon optically, directly from the specular reflection of the ray, resolving the above two problems. Further, this study proved that the concept of isotropic and anisotropic spaces underlies the mirror recognition and the mirror reversal phenomenon.
Time-resolved momentum microscopy with fs-XUV photons at high repetition rates with flexible energy and time resolution
Authors: Schiller Karl , Stupar Matija , Sternemann Lasse , Omar Alan , Saraceno Martin , Nitschke Jonah , Mischke Valentin , Janas David , Ponzoni Stefano , Zamborlini Giovanni , Saraceno Clara , Cinchetti Mirko
Published: June 2024

Time-resolved momentum microscopy is an emerging technique based on photoelectron spectroscopy for characterizing ultrafast electron dynamics and the out-of-equilibrium electronic structure of materials in the entire Brillouin zone with high efficiency. In this article, we introduce a setup for time-resolved momentum microscopy based on an energy-filtered momentum microscope coupled to a custom-made high-harmonic generation photon source driven by a multi-100 kHz commercial Yb-ultrafast laser that delivers fs pulses in the extreme ultraviolet range. The laser setup included a nonlinear pulse compression stage employing spectral broadening in a Herriott-type bulk-based multi-pass cell. This element allows flexible tuning of the driving pulse duration, providing a versatile time-resolved momentum microscopy setup featuring two operational modes designed to enhance either the energy or time resolution. We show the capabilities of the system by tracing ultrafast electron dynamics in the conduction band valleys of a bulk crystal of the 2D semiconductor WS2. Using uncompressed driving laser pulses, we demonstrated an energy resolution better than (107 ± 2) meV, while compressed pulses lead to a time resolution better than (48.8 ± 17) fs.
Phytochemical Evaluation, Molecular Docking, ADMET Properties and Anticancer Activity of Ethanolic Extract of Solanum trilobatum Leaf Extract
Authors: Abilasha D. , Palanisamy P.
Published: June 2024

In this study, the anticancer potential of ethanolic extract of Solanum trilobatum leaf, which contained high quantities of alkaloids, terpenoids, steroids and flavonoids, was investigated. The GC-MS analysis detected 30 phytocompounds in the ethanolic extract and according to the Pubchem database, 10 of these phytocompounds have significant biological activity. When using AutoDock Vina, docking investigations were conducted using the cancer cell line proteins from the colon (5FGK) and cervical (4J96), respectively. ADMET predictions were made via SwissADME and the pkCSM online webserver. According to the molecular docking data, the phytocompound stigmasterol has better anticancer activity than reference drugs. Molecular docking studies found that stigmasterol had a higher docking score (-10.8 kcal/mol for 5FGK and -8.0 kcal/mol for 4J96) and more binding interaction than camptothecin. Silica gel column chromatography was used to isolate stigmasterol, which was afterwards characterized by IR, PMR, CMR, mass spectroscopy and elemental analysis. MTT tests comparing stigmasterol revealed the moderate efficacy (IC50 = 83.14 µg/mL HeLa & 115.23 µg/mL HCT116) than the reference drugs camptothecin (IC50 = 38.07 µg/mL HeLa & 72.51 µg/mL HCT116). These results indicated stigmasterol as a potential therapeutic option which is compatible with the traditional use of plant and and these findings have been supported by molecular docking and ADME properties.
Comprehensive Analysis of Areca catechu Flower Extracts: Quantitative Phytochemical Analysis, GC-MS Characterization and in vitro Antiurolithiatic Activity
Authors: Govinda K. Adarsha , Fernandes Jennifer , Anusha S. , DSouza Nishmitha G.
Published: June 2024

Despite the fact that the root, fruit, and pulp of Areca catechu are claimed to possess antiurolithiatic properties, there is no information that has been documented regarding the flowers of the plant. The study was to confirm the active ingredients of Areca catechu flower and characterized by the GC-MS technique. The preliminary phytochemical analysis and the assessment of the total content were performed on a different type of extracts of Areca catechu flowers. The antiurolithiatic activity of A. catechu was determined by nucleation assay, growth assay and titrimetric method. The highest yield was obtained with methanol (7.4%), while chloroform yield was minimal (1.8%). The extracts contained flavonoids, terpenoids, glycosides, steroids and phenolic compounds, while terpenoids, saponins and reducing sugars were absent. The hexane and petroleum ether extracts of A. catechu flowers contained 10 chemical constituents. While 13 chemical constituents were analyzed from the ethyl acetate, chloroform, ethanolic and methanolic extracts. It was found that methanolic extract exhibited better action than cystone in nucleation assay and signification inhibitory action in growth assay. The maximum percentage dissolution among the extracts was shown by methanolic extracts (75.35%) at the concentration of 100 mg/mL, whereas cystone showed maximum percentage (86.63%) dissolution at the concentration of 100 mg/mL. Moreover, A. catechu extracts also exhibited significant in vitro antiurolithiatic activity.
In silico Analysis of Antiviral Potential of New Coumarin Analogues against Coronavirus
Authors: Sa'ad Mohammad Auwal , Ravichandran Manickam , Fuloria Shivkanya , Pattabhiraman Lalitha , Ravichandran Veerasamy , Mohd Yusop Faizul Fikri , Fuloria Neeraj Kumar
Published: June 2024

In silico designing of new chemical moieties to develop as active therapeutic agents is a continuous process. COVID-19 pandemic realized coronaviruses to pose significant global health threat. Current study presents in silico antiviral potential of novel coumarin analogues (NCAs) against coronaviruses through molecular docking analysis (MDA) and quantitative structure-activity relationship (QSAR) analysis. This study explores the binding affinity and structure-activity relationships of NCAs, focusing on their interaction with the SARS-CoV-2 spike protein N-terminal domain. MDA, particularly highlighting compound 5e, suggests promising binding interactions. Additionally, the QSAR studies identified key molecular descriptors influencing coronavirus inhibition activity and cytotoxicity (CC50), leading to the development of robust QSAR models meeting OECD criteria. These models demonstrate the stability, validity and applicability of NCAs as potential antiviral agents against coronaviruses. The promising result of new coumarin analogues provides a foundation for the development of novel therapeutics aimed to combat coronaviruses.
Effect of Zinc Doping and Porosity on Structural, Morphological and Gas Sensing Properties of Porous Zn:SnO2 Bilayer Thin Film
Authors: Yogasaraswathi R. , Dheepa J.
Published: June 2024

The automated nebulizer spray pyrolysis technique was used to synthesize porous SnO2 bilayer thin films as well as doped porous SnO2 bilayer thin films with varying zinc doping percentages. The synthesized thin films were characterized using X-ray diffraction, field emission scanning electron microscopy, energy dispersive analysis of X-rays, UV-Vis spectroscopy, photoluminescence spectroscopy, current-voltage characteristics and gas sensing performance. The effect of doping on sensor response was investigated using various gases and operating temperatures. The optimized Zn-doped porous SnO2/SnO2 gas sensor sample was taken to further gas sensing analysis. The results revealed that the doping of zinc with a porous tin oxide bilayer increases the gas sensor response at low operating temperatures compared to undoped porous tin oxide bilayers and it also reduces the response recovery time of the sensor. The response of the sensor in a CO gas concentration of 400 ppm has been improved with good repeatability.
Production of Oleic Acid from Mango Kernels Waste using Probiotic Bacteria Isolated from Marine Fishes
Authors: Anandan Rubavathi , Kannan Visali , Sivakumar Lavanya , Ramarao Venkatajothi , Athiappan Murugan
Published: June 2024

Oleic acid is a mono-unsaturated omega-9 fatty acid that serves as an antioxidant, antibacterial, antidiabetic, anti-inflammatory, anticancer and antidepressive agents. The present study focused on the production of oleic acid from mango kernel waste as an alternate method for conventional chemical extraction. An alternate mechanism has been devised to synthesize oleic acid from agro-industrial waste using probiotic bacteria and has been found to be economical. Microbial production of oleic acid from kernels discharged as waste from mango pulp processing industrial waste is a typical example of the valorization. The results of the present study demonstrated 5.26 mg/100 mL of oleic acid production using gut bacterial isolates from marine fish. Optimization of oleic acid production with response surface methodology by using Design-Expert has shown 40 mg/100 mL at pH 6.0, 15 ºC and 25 g concentration of mango kernel substrate with 48 h of incubation. The oleic acid produced using gut bacteria have been confirmed with the GC-MS fatty acid methyl ester. Therapeutic applications of oleic acids like antioxidant, anti-inflammatory and antibacterial activities were found to be promising.
Synthesis, Antioxidant and Cytotoxic Activity Studies of 2-Chlorobenzo[h]quinoline containing 2,4,5-Trisubstituted Imidazole Derivatives
Authors: Somashekara B. , Vijayakumar G.R. , Thippeswamy B.
Published: June 2024

A series of 2-chlorobenzo[h]quinoline containing 2,4,5-trisubstituted imidazole derivatives (4a-h) were synthesized and characterized by 1H NMR, 13C NMR, FT-IR and mass spectral analysis. All the synthesized compounds were evaluated for their in vitro antioxidant activity by DPPH method and cytotoxicity study against Colo-205, HeLa and A549 human cancer cell lines by MTT assay method. Among the synthesized compounds, compound 4a has showed significant cytotoxicity against all the three tested cancer cell lines, compound 4f showed good cytotoxic activity against Colo-205 and HeLa cell lines, while compound 4c has showed good cytotoxicity against HeLa cell line. With respect to antioxidant activity, the synthesized compounds 4a, 4d and 4e found to exhibit good activity as compared to other compounds of the series.
Metal Organic Framework Based Membranes for Efficient Wastewater Purification: Syntheses and Applications: A Review
Authors: Suin Supratim
Published: June 2024

Wastewater treatment utilizing metal organic framework (MOF) based membranes have gained significant attention in recent years owing to their versatile range of properties, ease of synthesis and tunable geometry of pores. During the last decade, innumerable attempts have been executed by global scientific communities in the development of novel MOF based membranes for eliminate several constituents, such as, heavy metals, oil and micro-pollutant, organic dyes, etc. This review aims to explore the synthetic methods for MOFs, as well as, MOF based membranes for efficient water purification and their applications in removing the causes of water pollution. This study also enlighten the applications of MOFs based membranes in the desalination of brackish and seawater. So, this review covers all the key synthetic strategies of MOFs-based membranes and their use in purifying and elimination of different hazardous material of wastewater.
A Divergent Synthesis and in vitro Biological Evaluation of Novel Pyrazolyl Chalcones and Pyrazolyl Flavones
Authors: Laskar Tanjima Tarique
Published: June 2024

A total of sixteen flavonoids, eight each of pyrazolyl chalcones [IM-3(a-h)] and pyrazolyl flavones [IM-4(a-h)] were synthesized and tested for in vitro antidiabetic, antiarthritic, anticoagulant, anthelmintic, anti-inflammatory and antioxidant activities by various methods such as α-amylase inhibitory method, egg albumin denaturation method, prothrombin time method, paralysis and death time method, bovine serum denaturation method and DPPH radical scavenging activity method, respectively. Structural analysis of the synthesized chalcone and flavone derivatives was carried out by various characterization techniques such as IR, 1H NMR, 13C NMR, LC-MS and elemental analysis. Out of all the synthesized derivatives IM-3a containing dibenzyloxy groups had displayed the most promising activity in all the in vitro analysis with IC50 value ranging from 59.33 ± 10.26-144.44 ± 11.16 µg/mL. Compound IM-3a may prove to be a potential therapeutic option owing to its strong antidiabetic, antiarthritic, anticoagulant, anthelmintic, anti-inflammatory and and antioxidant properties.
Combustion Synthesis and Study of Crystallographic and Luminescence Aspects of Double Perovskite Ba2BiYO6:Sm3+ Nanocrystal for Modern Lighting Applications
Authors: Garg Ojas , Kumar Mukesh , Dalal Hina , Devi Poonam , Sehrawat Neeraj , Solanki Diksha , Dahiya Sunita
Published: June 2024

A Sm3+-activated double perovskite Ba2BiYO6 nanocrystal system exhibiting a strong orange-red luminescence was prepared using an energy-efficient solution combustion synthetic procedure. The crystal structures were found to be cubic and belong to the Fm3m (225) space group with irregular shapes having a mean diameter of 51 nm. The surface aspects were explored via scanning and transmission electron microscopic (SEM and TEM) techniques. After exposure to UV energy (410 nm), the nanocrystals emit a active reddish-orange light at 16447 cm-1, caused by the transition from the 4G5/2→6H7/2 electronic state. The effects of energy transfer were also considered. The highest photoluminescence emission intensity occurs at a concentration of 3.0 mol% Sm3+ ions after which starts declining owing to the formation of d-d interactions of concentration quenching. The colour coordinates, based on the chromaticity chart, fall within the reddish region and the correlated colour temperature (CCT) value was measured at 1715 K for optimal sample Ba2BiY0.97Sm0.03O6. Consequently, these nanocrystals are well-suited for use in white lighting emitting (WLED) manufacturing and designed primarily for the purpose of constructing attractive modern lighting components.
In vivo and in silico Antifungal Activity of Cinnamon Leaf Oil and Lemongrass Oil containing Chitosan Microcapsules against Aspergillus flavus
Authors: Kumarathunga P.G.J.D. , Chathurangi S. , Rajapaksha R.P.S.P. , Sooriyawansha A.M.S.C. , Jayawardena P.A.S.N.P. , Dananjaya P.D.H. , Alwis M.D.N. , Kadigamuwa C.C. , Dahanayake J.N. , Wickramarachchi S.R.
Published: June 2024

This study aimed to examine the potentiality of microencapsulated cinnamon leaf oil (CNO-CS-MCs) and lemongrass oil (LGO-CS-MCs) as natural fungicides against Aspergillus flavus. Oil encapsulated microcapsules were synthesized using ionotropic gelation method. Cinnamon leaf oil (CNO) and lemongrass oil (LGO) were characterized using GC-MS. A. flavus was isolated and identified using DNA sequencing. The minimum inhibitory and minimum lethal doses of oil-loaded microcapsules against A. flavus were evaluated under in vivo conditions and the results were further confirmed by in silico analysis. The major constituents of CNO and LGO were eugenol and citral, respectively. The minimum inhibitory doses of CNO-CS-MCs and LGO-CS-MCs were 5 mg and 7.5 mg, respectively. The minimum lethal dose of CNO-CS-MCs was 12.5 mg. As CNO showed considerably high antifungal activity than LGO, Computational investigations were carried out on the action of CNO against A. flavus. The highest protein-ligand interaction was observed for squalene epoxidase (SQ)-benzyl benzoate (BEN) complex with the binding energy of -7.70 kcal/mol. Molecular dynamics simulations were performed on SQ-BEN complex for 10 ns using CHARMM36 force field. The Rg, RMSD and RMSF results indicated the stabilization of the SQ-BEN complex throughout the simulation time.
Effect of Additive (1-Butyl-1-methyl Pyrrolidinium Tetrafluoroborate) on Volumetric, Acoustic and Conductance Properties of Binary Aqueous Solutions of Benzylamine at T = (288.15, 298.15, 308.15, 318.15) K
Authors: Nidhi  , Thakur Ramesh Chand , Kumar Ashish , Sharma Praveen Kumar , Singh Kuldeep
Published: June 2024

Effect of additive, 1-butyl-1-methyl pyrrolidinium tetrafluoroborate [BmPyrr+][BF4–] on the volumetric, acoustic and conductance properties of binary aqueous solution of benzylamine has been analyzed at equidistant temperature range using different techniques. Using density and speed of sound data, volumetric and acoustic parameters like apparent and partial molar volumes (Vφ and Vφ0), apparent and partial molar isentropic compressions (Kφ,S and K0φ,S), partial molar volume of transfer and partial molar isentropic compression of transfer (ΔVφ0 and ΔK0φ,S) have been calculated. Conductance parameters like molar conductance (Λm), limiting molar conductance (Λ°m) and activation energy are also calculated using conductance data. All these parameters were used to analyze various types of interactions present in the system. Furthermore, density functional theory (DFT) calculations were conducted for comprehensive understanding of structural variations of ion pairs affecting their physical properties. The hydrogen bond formation in the mixture components was examined by using IR spectrum. Both DFT and Hartee-Fock (HF) methods were used to analyze the results. In addition, the DFT/B3LYP-D3 calculations were also carried out to gather data on the molecular geometry, interactions and other molecular characteristics of the ionic liquid under study.
Development of Platinum-Free Yttrium-Ion-Substituted NiS-Graphene Nanocomposites for DSSC and Photocatalytic Applications
Authors: Priyadharshini G. , Geetha D. , Ramesh P.S.
Published: June 2024

A good catalytic material for the counter electrode is necessary for the dye sensitized solar cell (DSSC), which must have low cost and high power conversion efficiency. Hence, this study aims to develop an efficient graphene based yttrium doped NiS (Y-NiS/GO) nanocomposite as a counter electrode material which is an alternative material to replace platinum in DSSC. For this, NiS/GO and yttrium doped NiS/GO composite were prepared by facile hydrothermal method. The structural, size, shape and physical properties of synthesized samples were characterized by XRD, FESEM-EDX, PL, UV-DRS techniques and to evaluate the properties of the oxidation state of nanocomposite, XPS technique were adopted. The XPS confirm the elements present in sample, further, series resistance (Rs) of yttrium doped NiS/GO composite has been calculated by impedance measurement (EIS). The conversion efficiency of solar cell increases from 2.72% to 3.23%. The same material is used as a nanophoto catalytst for degrading malachite green dye under natural sunlight. The photocatalytic activities of NiS, NiS/GO and Y-NiS/GO was examined and the photodegradation increases from 86% to 97% within 180 min at pH 8.
Synthesis of Novel 2-Quinolone linked 1,2,3-Triazole Derivatives as Potent Antimicrobial Activities: in silico Docking Studies
Authors: Chandrakar Komal , Sureddy Naveen Kumar , Mahapatra S.P. , Penta Santosh
Published: June 2024

The current research focuses on organic and medicinal chemistry, with a specific emphasis on the synthesis of molecules that incorporate diverse heterocycles. As part of this investigation, we have explored the fusion of 2-quinolone with 1,2,3-triazoles. Analytical and spectral data were applied to elucidate the structure of the synthesized compounds. In the preliminary antibacterial studies, analogs 4a, 4f, 6d and 6a were more effective against S. epidermidis corresponding MIC values of 6.32 ± 0.04, 2.38 ± 0.01, 5.18 ± 0.03 and 14.33 ± 0.01 µg/mL, respectively. In addition, compound 4a exhibited outstanding antibacterial activity against strains of Pseudomonas aeruginosa, as evidenced by a remarkable minimum inhibitory concentration (MIC) value of 3.19 ± 0.04 µg/mL. In particular, the synthesized scaffolds 6d, 4f, 4c and 4a showed significant antifungal activity with MIC values of 2.70 ± 0.01, 3.74 ± 0.03, 3.16 ± 0.02 and 4.18 ± 0.03 µg/mL against Candida albicans. The essential binding mode active site interactions in the DNA gyrase complex from Staphylococcus aureus based antibacterial drug candidate with 2XCO protein was also investigated and ligand 4a possesses the highest interacting amino acid residues ArgA:1092, PheA:1266, LysA:1043, AlaA:1172, AlaA:1034, TyrA:1099, HisA:1046, HisA:1046 [O11···NH], GlnA:1267 [O12···NE2], GlyA:1041 [N14···O, 3.22 Å], ThrA:1181 [O1···N]. The resulting scaffolds were assessed for ADMET and physico-chemical characteristics using ADMETlab2.0server, SwissADME web as good drugs with oral bioavailability.
A Precise Iris Positioning Technique Using a Modified Occlusal Plane Analyser - A Case Report
Authors: Samiksha Lalsare  , Sattyam Wankhade  , Arun Khalikar  , Suryakant Deogade  , Archit Kapadia
Published: June 2024

The eye is a vital organ, a key aspect of facial expression and the essence of cosmetic appearance in human beings.[1] Surgical intervention and removal of the eyeball may be required due to accidental trauma, pathology or congenital defects.[2] The disfigurement associated with the loss of an eye can cause immense physical, psychosocial and emotional disturbance.[3] The surgery involved can vary from minimal surgical intervention, such as evisceration or enucleation, to extensive radical treatment, such as exenteration.[4] The associated psychological distress can be reduced by timely rehabilitation with a prosthetic eye.[5]
An ocular prosthesis can be either stock or custom-made. Typical stock ocular prostheses come in a variety of standard sizes, contours, forms, and colours. They tend to be used for interim or postoperative purposes.[6] Although prefabricated ocular prostheses are easily available, poor fit, poor aesthetics, and poor eye movements are the inevitable disadvantages associated with them. All these can be overcome by fabricating a customized ocular prosthesis that provides a more intimate contact with the tissues.[7]
There are various methods described in literature for iris positioning in a custom ocular prosthesis such as, use of eyewear with graphic grid positioning,[8] use of facebow with graphic grid method,[9] McArthur’s ocular locator and fixed calliper,[10] Robert’s pupilometer,[11] Benson visual judgement.[12]
All these techniques help in locating the iris position in an ocular prosthesis. However, the Benson visual judgment is subjective in nature, and both the graph grid and the ocular locator techniques pose difficulty in stabilization and cannot be used in patients with facial asymmetry.[13]
To overcome the limitations of the existing techniques, a simple and efficient method using a modified occlusal plane analyser has been described in this article.
Hysterosalpingography - A Re-Emerging Study with Current Application
Authors: Pushpa Ranjan  , Rajeev Ranjan
Published: June 2024

The above article has been retracted.
Original Citation-
Pushpa Ranjan, Rajeev Ranjan. “Hysterosalpingography - A Re-Emerging Study with Current Application.” Journal of Evolution of Medical and Dental Sciences 2015; Vol. 4, Issue 99, December 10; Page: 16457-16463,
DOI: 10.14260/jemds/2015/2442
VBL Learning Device Validation (Tracker) on GJB Material Through the PBL Model
Authors: Pratama Bagus , Diyana Tsania Nur
Published: June 2024

This study aims to describe the validity of the VBL learning device (Tracker) on GJB material through the PBL model. This research is research and development, but this article is only at the validity stage. The research instrument used is a validation sheet. The resulting learning tools are validated by one expert. The results of the analysis show that 1) the validity of the device in terms of the validation of the RPP (Learning Implementation Plan) obtains a score of 3.65 in the valid category, the validity of the LKPD (Student Worksheets) obtains a score of 3.81 in the valid category, and the validity of the THB (Learning Outcomes Test) obtains score 4 valid theory. It was concluded that the VBL learning tool (Tracker) on GJB material through the PBL model is in the valid category so that it can be used for the next development stage.
Development of a Multimedia Learning Module (MLM) Based on Local Wisdom of the Banga Welu Game to Increase Student Motivation in Physics Learning
Authors: Gusemanto Theofiulus Gratiamus , Hidayatullah Zul
Published: June 2024

This research aims to: (1) produce a multimedia learning module (MLM) based on the local wisdom of the Banga Welu game that is suitable and valid for use in learning, and (2) determine the effectiveness of a multimedia learning module (MLM) based on the local wisdom of the Banga Welu game in increasing motivation students in learning physics. This research is included in Research & Development (R&D) research according to the development design from 4D. The research design used in product trials is a pretest-posttest control group design. The subjects in this research consisted of 104 instrument and product testing students. Product validation was carried out using an ideal standard score (Sbi) and General Linear Model (GLM) with a significance level of 0.05 to test the product's effectiveness in increasing students' motivation in learning physics. The validation results of the validators show that the multimedia learning module (MLM) based on the local wisdom of the Banga Welu game is very suitable for use both in terms of the media aspect and the material aspect contained in it. The GLM with effect size result of students' physics learning motivation is 0.242 and is in the medium category. The results of this effect size test show that the multimedia learning module based on the local wisdom of the Banga Welu game effectively motivates students to learn physics.
The Development of an Integrated Physics Module with Augmented-Assisted-Qur'an for Measurement Material
Authors: Handayani Fitria , Idrus Hadiyati , Chandra Artha Nesa , Agustiyanto Frans Rizal
Published: June 2024

The main problems of current research are the limited measuring tools, handout-based teaching materials and 2D illustrated textbooks that are less varied, and the lack of integration of Al-Qur'an material with technology-based applications. In the educational field, one of the technological advancements is Augmented Reality (AR) which provides a shifting experience from 2D images to 3D. Therefore, technological integration is important to realize a physics module about measurement material and the Al-Qur’an to make students interested in learning by associating the teaching material and the everyday life context.  This R&D applied the 4D model (Define, Design, Development, Dissemination). However, this research is limited to the practical development stage. The researchers used validation sheets from 3 aspects: material and media validation by 3 validators, and interpretation validation by 2 validators. The researchers distributed the practicality sheets to 2 teachers and 28 students The results of data analysis of material validation, media validation and expert interpretation obtained percentages consecutive percentages of 94.5%, 83.3%, and 91.6% with the category of very valid. Meanwhile, the practicality of the module based on the educators and students was 98.6% and 86.4% with the category of very practical.
Giuseppe Verdi and Politics: A socio-political study of Verdi’s Operas
Authors: Yazar İlhan Uğur
Published: June 2024

This article explores the close relationship between the operas of Giuseppe Verdi and the political context of 19th-century Italy. It examines how Verdi, through his musical and dramatic choices, reflected and influenced the Risorgimento movement, the struggle for Italian unification. While acknowledging the complexities of interpreting artistic works through solely political lenses, the article argues that Verdi's operas cannot be fully understood without considering their embeddedness within the turbulent political landscape of his time.
Verdi, revered as the national composer of Italy, lived at the heart of a period of immense political upheaval. The Risorgimento, a movement seeking to unify Italy into a single nation, deeply shaped his life and artistic expression. This article delves into how Verdi's operas served as both mirrors and megaphones, reflecting the anxieties and aspirations of the Italian nation in flux while simultaneously influencing the public opinion and galvanizing support for the national unification cause.
(Extended English summary is at the end of this document)
 
Özet
Bu makale, Giuseppe Verdi'nin operaları ile 19. yüzyıl İtalya'sının siyasi bağlamı arasındaki yakın ilişkiyi araştırmaktadır. Bu bağlamda, Verdi'nin dramatik müzikal eserleriyle, İtalyan ulusal birleşme mücadelesi olan Risorgimento hareketini nasıl yansıttığı ve yansıtmaktan da öteye geçerek nasıl motive ettiği incelenmektedir. Makalede, sanatsal eserlerin yalnızca siyasi bakış açısıyla yorumlamanın karmaşıklığı kabul edilirken, Verdi'nin operalarının, kendi zamanının çalkantılı siyasi ortamı ile iç içe geçmiş olduğu dikkate alınmadan tam olarak anlaşılamayacağını vurgulanmaktadır.
İtalya'nın ulusal bestecisi olarak büyük saygı duyulan Giuseppe Verdi, yabancı yönetimi altındaki parçalı bir ülke içinde ve ciddi bir siyasi çalkantı döneminin kalbinde yaşadı. İtalya'yı tek bir ulus halinde birleştirmeyi amaçlayan bir hareket olan Risorgimento, onun hayatını ve sanat eserlerinin ortaya koyduğu ifadeyi derinden şekillendirdi. Bu makale, Verdi'nin operalarının toplumsal anlamda nasıl hem bir ayna hem de bir seslendirici görevi gördüğünü, bu bağlamda değişim halindeki bir ulusun endişelerini ve isteklerini yansıtırken aynı zamanda kamuoyunu da nasıl etkilediğini ve İtalya’daki ulusal birleşme davasına yönelik halkın desteğini nasıl harekete geçirdiğini ele almaktadır.
Energy efficiency in cooling systems: integrating machine learning and meta-heuristic algorithms for precise cooling load prediction
Authors: Xu Kunming
Published: June 2024

Since cooling load estimation directly impacts air conditioning control and chiller optimization, it is essential for increasing the energy efficiency of cooling systems. Machine learning outshines traditional regression analysis by efficiently managing vast datasets and discerning complex patterns influenced by various factors like occupancy, building materials, and meteorology. These capabilities greatly enhance building management and energy optimization. The primary objective of this study is to introduce a framework based on ML algorithms to accurately predict cooling loads in buildings. The Decision Tree model was chosen as the core algorithm for this purpose. Furthermore, as an innovative approach, four metaheuristic algorithms – namely, the Improved Arithmetic Optimization Algorithm, Prairie Dog Optimization, Covariance Matrix Adaptation Evolution Strategy, and Coyote Optimization Algorithm – were employed to enhance the predictive capabilities of the Decision Tree model. The dataset which utilized in this study derived from previous studies, the data comprised of eight input parameters, including Relative Compactness, Surface Area, Wall Area, Roof Area, Overall Height, Orientation, Glazing Area, and Glazing Area Distribution. With an astonishing R
2 value of 0.995 and a lowest Root Mean Square Error value of 0.660, the DTPD (DT + PDO) model performs exceptionally well. These astounding findings demonstrate the DTPD model’s unmatched precision in forecasting the results of cooling loads and point to its potential for useful implementation in actual building management situations. Properly predicting and managing cooling loads ensures that indoor environments remain comfortable and healthy for occupants. Maintaining optimal temperature and humidity levels not only enhances comfort but also supports good indoor air quality.