bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduced cortical thickness and increased gyrification in generalized anxiety disorder: a 3 T MRI study
Authors: Molent Cinzia , Maggioni Eleonora , Cecchetto Filippo , Garzitto Marco , Piccin Sara , Bonivento Carolina , Maieron Marta , D'Agostini Serena , Balestrieri Matteo , Perna Giampaolo , Altamura A. Carlo , Brambilla Paolo
Published: December 2017

Background

Although the study of the neuroanatomical correlates of generalized anxiety disorder (GAD) is gaining increasing interest, up to now the cortical anatomy of GAD patients has been poorly investigated and still no data on cortical gyrification are available. The aim of the present study is to quantitatively examine the cortical morphology in patients with GAD compared with healthy controls (HC) using magnetic resonance imaging (MRI). To the best of our knowledge, this is the first study analyzing the gyrification patterns in GAD.

Methods

A total of 31 GAD patients and 31 HC underwent 3 T structural MRI. For each subject, cortical surface area (CSA), cortical thickness (CT), gray matter volume (GMV), and local gyrification index (LGI) were estimated in 19 regions of interest using the Freesurfer software. These parameters were then compared between the two groups using General Linear Model designs.

Results

Compared with HC, GAD patients showed: (1) reduced CT in right caudal middle frontal gyrus (p < 0.05, Bonferroni corrected), (2) hyper-gyrification in right fusiform, inferior temporal, superior parietal and supramarginal gyri and in left supramarginal and superior frontal gyri (p < 0.05, Bonferroni corrected). No significant alterations in CSA and GMV were observed.

Conclusions

Our findings support the hypothesis of a neuroanatomical basis for GAD, highlighting a possible key role of the right hemisphere. The alterations of CT and gyrification in GAD suggest a neurodevelopmental origin of the disorder. Further studies on GAD are needed to understand the evolution of the cerebral morphology with age and during the clinical course of the illness.
Understanding old-age adaptation policies in Europe: the influence of profit, principles and pressures
Authors: LÖSSBROEK JELLE , LANCEE BRAM , VAN DER LIPPE TANJA , SCHIPPERS JOOP
Published: December 2017

To cope with an increased proportion of older workers, organisations develop old-age adaptation policies. Two strategies underlie these policies: phasing out and activating. Although the existence of these strategies is widely recognised, the reasons for their presence have rarely been explored. We identify three arguments that explain the extent to which these strategies are present: profit, principles and pressures. We hypothesise that the intensity of the phasing out strategy is higher when it is profitable and easy to replace older workers, when employer's age norms support the principle of treating older workers differently, and when external pressures are high. We also hypothesise that the intensity of the activating strategy is higher when it is profitable but hard to replace older workers, when the employer's age norms reject the principle of treating older workers differently, and when external pressures are high. We use pooled regression analysis to study imputed managerial data from 5,410 organisations in seven European countries. Results confirm the importance of external pressures for the adaptation of both strategies, and of principles for activating. Although policy feasibility is important for the adaption of both strategies, the other profit variables showed mixed results. Net benefits of older workers to the organisation are only important for phasing out, and substitutability only for activating. This paper discusses the wider implications of the study.
The Protection of Cultural Property: Post-Colonial and Post-Conflict Perspectives from Sri Lanka
Authors: Kamardeen Naazima
Published: December 2017

Cultural property is related to the evolution of a nation’s identity. It forms a vital link to the past, wherefrom the present and future may be nurtured and enriched. However, objects related to cultural heritage have been the target of looting and pilfering, resulting in loss to the country concerned. The situation is worsened where these objects have been removed during an era where there were no laws and regulations to control such removal. This article focuses on the loss of cultural property with reference to two specific modes of loss of particular concern to Sri Lanka—the removal of cultural property during the colonial era and the loss of cultural property during the more recent ethnic conflict. Through an analysis of the relevant laws and regulations, this article evaluates Sri Lanka’s rights to its cultural property and its efforts to regain, and preserve, its cultural heritage.
Pulsus alternans in a child with dilated cardiomyopathy
Authors: Sanandajifar Hasti , Batlivala Sarosh P.
Published: December 2017

A previously healthy 21-month-old presented with new-onset dilated cardiomyopathy. Evaluation noted pulsus alternans, with beat-to-beat alternations in aortic pulse wave amplitude, both clinically and on diagnostic studies. Pulsus alternans is an infrequent, complex pathophysiologic sign often associated with severe heart failure. The mechanisms are incompletely understood, but theorised aetiologies include beat-to-beat changes in left ventricular loading conditions, variations in myocardial oxygen supply/demand, and alternations in myocardial contractility. Recognition of pulsus alternans is important as it provides significant clinical information, may suggest suboptimal medical management, and may be the first warning sign of severe cardiac dysfunction.
Isolation and characterization of microsatellite markers for the red alga Porphyra umbilicalis
Authors: Varela-Álvarez Elena , Balau Ana C. , Paulino Cristina , Berecibar Estibaliz , Pearson Gareth A. , Serrão Ester A.
Published: December 2017

The red algal genus Porphyra is sister to the genus Pyropia, the single most valuable marine crop in the Orient. We developed microsatellite loci for the red alga Porphyra umbilicalis, a widespread species in the Northern Atlantic. Enriched DNA libraries were constructed and 68 loci were screened for amplification and polymorphism. Seven polymorphic microsatellite markers were isolated using 44 individuals collected from four natural populations. The number of alleles per locus ranged from two to 12. Null alleles were detected in three loci. Among the markers reported, we tested also cross-amplification with two other Porphyra spp. These polymorphic microsatellite markers should be useful for investigating population genetic structure of P. umbilicalis in the North East Atlantic.
Variation in Response and Resistance to Glyphosate and Glufosinate in California Populations of Italian Ryegrass (Lolium perennessp.multiflorum)
Authors: Karn Elizabeth , Beffa Roland , Jasieniuk Marie
Published: December 2017

Reduced control of Italian ryegrass in California with herbicides has raised concerns about the evolution of populations with resistance to multiple herbicides. The goal of this study was to investigate variation among populations in plant response and resistance to glyphosate and glufosinate in Italian ryegrass from vineyards and orchards in northwest California. Population resistance screening using field-collected seed revealed up to 56.9% of individuals surviving glyphosate treatment at 1,678 g ae ha−1, and 53.5% of individuals surviving glufosinate treatment at 2,242 g ai ha−1in the same population. Frequencies of surviving plants within populations varied among screening times, particularly for glufosinate. Treating vegetatively propagated, genetically identical tillers with each herbicide pointed to separate mechanisms of resistance rather than cross-resistance to glyphosate and glufosinate. Dose–response experiments were conducted for each herbicide at two different screening times using a subset of populations, field-collected seed, and 10 herbicide rates. Plant survival and biomass were evaluated for each population at 3 wk after treatment and for plant regrowth 1 wk thereafter. Log-logistic regression models fit to the data were used to estimate LD50, GR50, and RD50values and calculate resistance indices (R/S ratios). Based on LD50values, the most highly resistant population was 14.4- to 19.2-fold more resistant to glyphosate than the most susceptible population tested but only 1.6- to 2.0-fold more resistant to glufosinate than the most susceptible population tested. Levels of resistance to both herbicides varied with screening time period and variable measured. Results indicate high frequencies of glyphosate-resistant plants but an early stage in the evolution of glufosinate resistance in some Italian ryegrass populations of northwest California.
Sex Assignment to Whole Human Responses in Rorschach
Authors: Mormont Christian , Fontan Patrick
Published: December 2017

Abstract. According to the theory of identification, men are more likely to qualify their Rorschach human content responses as males, and women as females. These assumptions were tested in an empirical investigation using a Belgian nonpatient sample of 800. All human responses and their location were listed. Analyses were carried out on the 10 Cards and on the formal quality (FQo vs. FQu/−) of all human responses according to the subject’s and the examiner’s sex. Variables were first submitted to principal component analysis, and resulting components were compared in a 2 × 2 design in order to assess examiners’ and participants’ sex potential effects on human responses sex assignments. Univariate and multivariate ANOVA revealed no or only negligible differences. In a second step, distributions of masculine, feminine, and neutral human responses across 16 card locations that commonly elicit human responses were submitted to hierarchical clustering in order to identify masculine, feminine, and neutral locations in Rorschach cards. Chi-square tests revealed no significant association between participants’ sex and human responses locations. Results do not corroborate predictions according to the theory of identification but they do, however, highlight the role of the distal features of blots.
Young People’s Engagement With the European Union
Authors: Strohmeier Dagmar , Barrett Martyn , Bora Carmen , Caravita Simona C. S. , Donghi Elisa , Dragoti Edmond , Fife-Schaw Chris , Gómez-López Mercedes , Kapéter Eszter , Mazzone Angela , Rama Rudina , Roşeanu Gabi , Ortega-Ruiz Rosario , Steiner Hanna , Trip Simona , Tenenbaum Harriet , Urhahne Detlef , Viejo Carmen
Published: December 2017

Abstract. This study investigated whether demographic variables, efficacy beliefs, visions, and worries are associated with four different forms of (dis)engagement with the European Union (EU): intended voting in the 2019 EU elections, nonconventional political engagement, psychological engagement, and the wish that one’s own country should leave the EU. The sample comprised 3,764 young people aged 16–25 years living in seven European countries: Albania, Austria, Germany, Italy, Romania, Spain, and the UK. Economic challenges, human rights, and the environment were the most important future visions; unemployment and poverty, climate change, civil unrests, and collapse of the EU were the most important future worries. The four forms of (dis)engagement with the EU were differentially associated with predictors, although internal efficacy and future vision of economic challenges predicted all forms. Implications for future EU policy are discussed.
Adolescent and Caregiver Perspectives on Provider–Patient Interactions in Type 2 Diabetes
Authors: Amirniroumand Roya , Valenzuela Jessica M. , Smith Laura B. , Nicholl Meg C. , Dolan Lawrence M. , Powers Scott W.
Published: December 2017

This study aimed to describe the experience of adolescents with Type 2 diabetes and their caregivers during medical encounters, in an effort to improve clinical care and outcomes in this population. Twenty-eight families were recruited from a Midwestern diabetes clinic. Adolescents (13–18 years old) identified as Black (50%), Caucasian (43%), and Hispanic (7%), with variable levels of glycemic control (glycosylated hemoglobin A1c = 5.1–12.9%). Participants completed demographic and disease-related (adherence) questionnaires. Six adolescent and six caregiver focus groups were conducted and transcribed, coded, and systematically analyzed using principles of thematic analysis. Participants reported moderate to high rates of nonadherence. Qualitative themes indicated multiple factors influencing perceptions of the quality of provider–patient interactions. Participants’ experiences of these interactions was affected by provider characteristics (e.g., gender, age), provider approach and communication style, systemic issues (e.g., long wait times), and caregivers assuming primary roles in medical encounters (e.g., more caregiver participation and caregiver disclosure of nonadherence). Focus group discussions provided rich information about the experiences of adolescents with Type 2 diabetes and implicate barriers in provider–patient interactions, including challenges in triadic interactions and communication around nonadherence, suggesting these areas should be considered in efforts to improve provider–patient interactions within this population.
Integrating Early Childhood Screening in Pediatrics: A Longitudinal Qualitative Study of Barriers and Facilitators
Authors: Silver Rebecca B. , Newland Rebecca P. , Hartz Karyn , Jandasek Barbara , Godoy Leandra , Lingras Katherine A. , Low Christine M. , Dickstein Susan , Campagna Kristine , Berger Blythe , Seifer Ronald
Published: December 2017

Pediatric settings are increasingly called upon to implement early childhood developmental and behavioral health screening as an early identification and health promotion strategy. Understanding the dynamic barriers and facilitators of implementation at various stages will help implementers plan for and address these factors in support of high quality implementation. Our research supported this goal by analyzing longitudinal, qualitative data. There were 128 semistructured interviews conducted with pediatric clinic and implementation providers across four years. Interviews were transcribed, coded, and synthesized using rigorous qualitative methods. Results were produced using an iterative process to summarize, analyze, and consolidate themes about screening implementation over time. Barriers and facilitators of implementation included characteristics of screening implementation as well as contextual characteristics of the pediatric primary care setting. Some implementation themes were stable over time whereas others demonstrated shifts. Results are discussed in terms of lessons learned for successfully integrating this critical preventive practice within pediatric clinics.
Genome-wide analysis of SSR and ILP markers in trees: diversity profiling, alternate distribution, and applications in duplication
Authors: Xia Xinyao , Luan Lin Lin , Qin Guanghua , Yu Li Fang , Wang Zhi Wei , Dong Wan Chen , Song Yumin , Qiao Yuling , Zhang Xian Sheng , Sang Ya Lin , Yang Long
Published: December 2017

Molecular markers are efficient tools for breeding and genetic studies. However, despite their ecological and economic importance, their development and application have long been hampered. In this study, we identified 524,170 simple sequence repeat (SSR), 267,636 intron length polymorphism (ILP), and 11,872 potential intron polymorphism (PIP) markers from 16 tree species based on recently available genome sequences. Larger motifs, including hexamers and heptamers, accounted for most of the seven different types of SSR loci. Within these loci, A/T bases comprised a significantly larger proportion of sequence than G/C. SSR and ILP markers exhibited an alternative distribution pattern. Most SSRs were monomorphic markers, and the proportions of polymorphic markers were positively correlated with genome size. By verifying with all 16 tree species, 54 SSR, 418 ILP, and four PIP universal markers were obtained, and their efficiency was examined by PCR. A combination of five SSR and six ILP markers were used for the phylogenetic analysis of 30 willow samples, revealing a positive correlation between genetic diversity and geographic distance. We also found that SSRs can be used as tools for duplication analysis. Our findings provide important foundations for the development of breeding and genetic studies in tree species.
Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice
Authors: Paul Rajib , Borah Anupom
Published: December 2017

There exists an intricate relationship between hypercholesterolemia (elevated plasma cholesterol) and brain functions. The present study aims to understand the impact of hypercholesterolemia on pathological consequences in mouse brain. A chronic mouse model of hypercholesterolemia was induced by giving high-cholesterol diet for 12 weeks. The hypercholesterolemic mice developed cognitive impairment as evident from object recognition memory test. Cholesterol accumulation was observed in four discrete brain regions, such as cortex, striatum, hippocampus and substantia nigra along with significantly damaged blood-brain barrier by hypercholesterolemia. The crucial finding is the loss of acetylcholinesterase activity with mitochondrial dysfunction globally in the brain of hypercholesterolemic mice, which is related to the levels of cholesterol. Moreover, the levels of hydroxyl radical were elevated in the regions of brain where the activity of mitochondrial complexes was found to be reduced. Intriguingly, elevations of inflammatory stress markers in the cholesterol-rich brain regions were observed. As cognitive impairment, diminished brain acetylcholinesterase activity, mitochondrial dysfunctions, and inflammation are the prima facie pathologies of neurodegenerative diseases, the findings impose hypercholesterolemia as potential risk factor towards brain dysfunction.
High-efficiency terahertz devices based on cross-polarization converter
Authors: Zhao Huan , Wang Xinke , He Jingwen , Guo Jinying , Ye Jiasheng , Kan Qiang , Zhang Yan
Published: December 2017

Metasurface-based devices have been investigated intensively because of their attractive properties but these devices generally suffer from low efficiency. Here we demonstrate several high-efficiency terahertz (THz) devices based on cross-polarization converters that is composed of bilayer metasurface-based structures. The converter can transfer the polarization states of transmitted THz waves from the x-direction into the y-direction with an experimental conversion efficiency of 85%. This high-efficiency transfer mechanism is investigated in detail. Furthermore, this kind of devices can be fabricated easily. A THz metalens is designed and fabricated and its focusing and imaging properties are investigated experimentally. A pure phase THz hologram that can generate different images on different propagation planes is also designed and the image reconstruction capabilities of the phase holograms are demonstrated experimentally. The performance levels of all designed devices show excellent agreement between the theoretical expectations and the corresponding experimental results. This technology may pave the way towards practical applications of such metasurface devices.
Modulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumor
Authors: Rocha Márcia , Arcanjo Rachel , Lopes Cláudio , Carneiro Marcella , Souza Aparecido , Báo Sônia
Published: December 2017

Degradation of cellular matrix is one of the important processes related to the progression of breast cancer. Tumor cells have the ability to exhibit necessary conditions for growth and survival, promoting degradation processes of extracellular matrix proteins, such as laminin (LN) and fibronectin (FN). In this study, we evaluated whether treatments, based on free rhodium (II) citrate (Rh2(H2cit)4), maghemite nanoparticles coated with citrate (Magh-cit) and maghemite nanoparticles coated with rhodium (II) citrate (Magh-Rh2(H2cit)4), in murine metastatic breast carcinoma models can modulate the expression of laminin and fibronectin proteins. Synthesized nanoparticles were characterized using X-ray diffraction, transmission electron microscopy, energy dispersive spectroscopy and dynamic light scattering. The expression of FN and LN was assessed using immunohistochemistry and western blotting. The gene expression of FN1 and LAMA1 were evaluated using real-time PCR. The FN1 and LAMA1 transcripts from the Magh-Rh2(H2cit)4 treated group were 95% and 94%, respectively, lower than the control group. Significant reduction in tumor volume for animals treated with Magh-Rh2(H2cit)4 was observed, of about 83%. We witnessed statistically significant reductions of FN and LN expression following treatment with Magh-Rh2(H2cit)4. We have demonstrated that the antitumor effects of Magh-Rh2(H2cit)4 and Rh2(H2cit)4 regulate the expression of FN and LN in metastatic breast tumors.
A Proposal to Stratify the Intermediate-Risk Thyroid Nodules According to the AACE/ACE/AME Guidelines with Ultrasound Features
Authors: Deng Xiao-Hong , Tang Li-Na , Liu Shui-Qing , Li Xiao-Long , He Ya-Ping , Xu Hui-Xiong
Published: December 2017

To propose a risk stratification system for intermediate-risk thyroid nodules (TNs) according to American Association of Clinical Endocrinologists, American College of Endocrinology and Associazione Medici Endocrinologi Medical (AACE/ACE/AME) Guideline with ultrasound (US) features. 1000 patients with 1000 nodules (902 benign nodules and 98 malignant nodules) were included. All the nodules were confirmed with either fine needle aspiration (FNA) cytology and follow-up or histology results after surgery. Univariate analysis and binary multivariate logic regression analysis were applied to analyze the possible risk US features associated with malignancy. Receiver operating characteristic curves (ROC) were drew and compared. Univariate analysis and binary multivariate logistic regression analysis showed that indeterminate hyper-echoic spot (OR = 4.544), slightly ill-defined margin (OR = 2.559), slight hyper-echogenicity (OR = 1.992) and no macro-calcification (OR = 1.921) were risk factors for the intermediate-risk thyroid nodules (TNs). A predicting model was established based on the 4 risk factors. The risk rates of malignancy were 5.7% (26/455) in Stage I, 11.0% (49/445) in Stage II, 23.1% (21/91) in Stage III, 33.3% (3/9) in Stage IV. In conclusion, for the intermediate-risk TNs, special attention should be paid to the TNs with indeterminate hyper-echoic spot, slightly ill-defined margin, slight hyper-echogenicity, or no macro-calcification. The probability of malignancy increased with the number of risk factors increasing.
Complete genome sequencing and genomic characterization of two Escherichia coli strains co-producing MCR-1 and NDM-1 from bloodstream infection
Authors: Zheng Beiwen , Yu Xiao , Xu Hao , Guo Lihua , Zhang Jing , Huang Chen , Shen Ping , Jiang Xiawei , Xiao Yonghong , Li Lanjuan
Published: December 2017

We previously described the discovery of two Escherichia coli isolates (EC1002 and EC2474) co-harbouring mcr-1 and blaNDM-1 genes, which were recovered from bloodstream infection in China. More importantly, these antibiotic resistance genes were located on different plasmids and signaling the potential spread of pandrug-resistant bacteria. Here, the complete genome sequences of both isolates were determined using Pacbio RS II and Illumina HiSeq2000 systems. The genome of EC1002 consists of a 5,177,501 base pair chromosome and four circular plasmids, while the genome of EC2474 consists of a 5,013,813 base pair chromosome and three plasmids. The plasmid replicon type of pEC1002_NDM and pEC2474_NDM were identified as IncA/C2 and IncF, respectively. The genetic environment of blaNDM-1 in this study was similar to blaNDM-carrying plasmids detected in China, although the overall nucleotide identity and query coverage were variable. The plasmid replicon type of pEC1002_MCR and pEC2474_MCR were identified as IncI2 and IncHI2, respectively. Two different genetic strategies for mcr-1 gene spread were observed in this study and blaNDM-1 genes were also found transferred by two different mobile genetic elements in two plasmids. The findings of this study further support that the diversified transfer mechanisms of blaNDM-1 and mcr-1 present in Enterobacteriaceae.
Intensive spa and exercise therapy program for returning to work for low back pain patients: a randomized controlled trial
Authors: Nguyen Christelle , Boutron Isabelle , Rein Christopher , Baron Gabriel , Sanchez Katherine , Palazzo Clémence , Dupeyron Arnaud , Tessier Jean-Max , Coudeyre Emmanuel , Eschalier Bénédicte , Forestier Romain , Roques-Latrille Christian-François , Attal Ygal , Lefèvre-Colau Marie-Martine , Rannou François , Poiraudeau Serge
Published: December 2017

We aimed to determine whether a 5-day intensive inpatient spa and exercise therapy and educational program is more effective than usual care in improving the rate of returning to work at 1 year for patients with subacute and chronic low back pain (LBP) on sick leave for 4 to 24 weeks. We conducted a 12-month randomized controlled trial. LBP patients were assigned to 5-day spa (2 hr/day), exercise (30 min/day) and education (45 min/day) or to usual care. The primary outcome was the percentage of patients returning to work at 1 year after randomization. Secondary outcomes were pain, disability and health-related quality of life at 1 year and number of sick leave days from 6 to 12 months. The projected recruitment was not achieved. Only 88/700 (12.6%) patients planned were enrolled: 45 in the spa therapy group and 43 in the usual care group. At 1 year, returning to work was 56.3% versus 41.9% (OR 1.69 [95% CI 0.60–4.73], p = 0.32) respectively. There was no significant difference for any of the secondary outcomes. However, our study lacked power.
Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823
Authors: Szeleszczuk Łukasz , Pisklak Dariusz Maciej , Zielińska-Pisklak Monika
Published: December 2017

This is a commentary on a paper by S. Aitipamula et al. (CrystEngComm, 2009, 11, 1823–1827) on the detailed analysis of the stability of trimorphic cocrystals.
Electrochemical performance and structure of Al2W3−xMoxO12
Authors: Schulz Bernd , Andersen Henrik L. , Al Bahri Othman K. , Johannessen Bernt , Liu Junnan , Primig Sophie , Sharma Neeraj
Published: December 2017

Al2W3−xMoxO12 shows an orthorhombic to monoclinic transition with increasing Mo concentration and ∼100 mA h g−1 capacity at 100 cycles in Li-cells.
Tailoring the epitaxy of Sb2Te3 and GeTe thin films using surface passivation
Authors: Momand Jamo , Boschker Jos E. , Wang Ruining , Calarco Raffaella , Kooi Bart J.
Published: December 2017

Depending on the substrate surface termination the epitaxy of chalcogenide thin films can be drastically altered. While GeTe grows with many randomly oriented domains on H-terminated Si(111), the in-plane alignment is significantly improved on Sb-terminated Si(111).
Refractory plasmonics: orientation-dependent plasmonic coupling in TiN and ZrN nanocubes
Authors: El-Saeed Ahmed H. , Allam Nageh K.
Published: December 2017

Transition metal nitrides have recently been considered as potential replacements for noble metals as plasmonic materials.
Intrinsic origin of intra-granular cracking in Ni-rich layered oxide cathode materials
Authors: Min Kyoungmin , Cho Eunseog
Published: December 2017

Stress–strain curves of Ni-rich NCM under different deformation modes and directions.
Anomalies in the low frequency vibrational density of states for a polymer with intrinsic microporosity – the Boson peak of PIM-1
Authors: Zorn Reiner , Yin Huajie , Lohstroh Wiebke , Harrison Wayne , Budd Peter M. , Pauw Brian R. , Böhning Martin , Schönhals Andreas
Published: December 2017

For the first time the low frequency vibrational density of states is reported for a polymer with intrinsic microporosity.
Synthesis and characterization of a novel aminopolycarboxylate complexant for efficient trivalent f-element differentiation: N-butyl-2-acetamide-diethylenetriamine-N,N′,N′′,N′′-tetraacetic acid
Authors: Heathman Colt R. , Grimes Travis S. , Jansone-Popova Santa , Ivanov Alexander S. , Bryantsev Vyacheslav S. , Zalupski Peter R.
Published: December 2017

Novel aminopolycarboxylate complexant N-butyl-2-acetamide-diethylenetriamine-N,N′,N′′,N′′-tetraacetic acid was synthesized to discriminate trivalent actinides from trivalent lanthanides in aqueous mixtures of unconventional acidity.
VIVO complexes with antibacterial quinolone ligands and their interaction with serum proteins
Authors: Sanna Daniele , Ugone Valeria , Sciortino Giuseppe , Buglyó Péter , Bihari Zsolt , Parajdi-Losonczi Péter László , Garribba Eugenio
Published: December 2017

VIVO complexes of quinolones were studied to couple their pharmacological activity with that of V. The interaction ofcis-VOL2(H2O) with apo-hTf, holo-hTf and HSA results in the formation {VOL2}y(Protein) species, withy= 1–3,viaHis binding of the proteins.
Three different types of bridging ligands in a 3d–3d′–3d′′ heterotrimetallic chain
Authors: Alexandru Maria-Gabriela , Visinescu Diana , Shova Sergiu , Andruh Marius , Lloret Francesc , Cano Joan , Julve Miguel
Published: December 2017

A novel example of an antiferromagnetically coupled {CuIIMnIICrIII} heterotrispin chain with double phenoxido, single cyanido and oxalato as bridging ligands was obtained by a one-pot synthesis.
Source-to-exposure assessment with the Pangea multi-scale framework – case study in Australia
Authors: Wannaz Cedric , Fantke Peter , Lane Joe , Jolliet Olivier
Published: December 2017

Global multi-scale modeling platform for spatial analysis of population intake and multimedia source apportionment of 4000+ Australian emission sources.
Synthesis and characterization of water-soluble macrocyclic peptides stabilizing protein α-turn
Authors: Wang Lei , Coric Pascale , Zhu Kexin , Liu Wang-Qing , Vidal Michel , Bouaziz Serge , Broussy Sylvain
Published: December 2017

Macrocyclic peptides mimic tight “non-classical” α-turn type II-αLS found in proteins, as shown by spectroscopic and computational analysis of their equilibrating conformations.
Luminescence and magnetocaloric effect of Ln4 clusters (Ln = Eu, Gd, Tb, Er) bridged by CO32− deriving from the spontaneous fixation of carbon dioxide in the atmosphere
Authors: Chen Hong-Man , Wang Wen-Min , Li Xiao-Qin , Chu Xiao-Ya , Nie Yao-Yao , Liu Zhen , Huang Shao-Xia , Shen Hai-Yun , Cui Jian-Zhong , Gao Hong-Ling
Published: December 2017

Ln4 clusters are bridged by CO32−, deriving from the spontaneous fixation of CO2. And the Gd4 complex can show MCE.
Solid phase extraction based on the phase transition of poly(N-isopropylacrylamide): the extraction behaviour of lanthanide(iii) ions in highly acidic solutions
Authors: Park Ki Chul , Tateno Haruka , Tsukahara Takehiko
Published: December 2017

The extraction of the complex of Ln(iii) ions and CMPO onto the PNIPAAm solid phase formed by phase transition was achieved in highly acidic solutions.
Glutathione-coated Fe3O4 nanoparticles with enhanced Fenton-like activity at neutral pH for degrading 2,4-dichlorophenol
Authors: Zhou Rui , Shen Ningfei , Zhao Jian , Su Yu , Ren Hejun
Published: December 2017

Fe3O4@GSH nanoparticles exhibit a strong affinity for H2O2 under neutral pH conditions.
Controlling fixed trap charge effect in FinFET using heterodielectric BOX
Authors: Das Rajashree , Baishya Srimanta
Published: December 2017

This Letter presents an Si FinFET on heterodielectric BOX, where the effect of trap charges can be avoided. The investigation is based on a 3D simulation study. The BOX height also plays a significant role in the device characteristics. The effect of trap charges using homodielectric and heterodielectric BOX is verified by plotting the electron density across a 2D cross section in the middle of the channel. The authors further investigated the effect of temperatures, ranging from room temperature to higher temperatures. The FinFET, with heterodielectric BOX, shows no trap effect even when the temperature is varied. On the other hand, a visible temperature effect is observed in case of homodielectric BOX. Moreover, in case of homodielectric BOX, the ON–OFF performance metric, (Q) is affected in presence of trap charges; whereas no change is observed when a heterodielectric BOX is used. As such, it is found that the FinFET with heterodielectric BOX is more reliable and useful for current semiconductor industries.
Freeway speedharmonisation experiment using connected and automated vehicles
Authors: Learn Stacy , Ma Jiaqi , Raboy Kelli , Zhou Fang , Guo Yi
Published: December 2017

One effective strategy of cooperative vehicle‐highway systems with connected and automated vehicles (CAVs) is speed harmonisation, which dynamically adjusts vehicle speed recommendations to reduce speed differentials. Speed harmonisation can be applied to potentially improve mobility and safety. This study documents the development of an innovative vehicle control platform and experimental design to conduct speed harmonisation field experiments. In our experiment, a fleet consisting of three CAVs and five probe vehicles was deployed on a roadway segment that experiences daily recurring traffic congestion. The objective of the CAVs was to regulate traffic upstream of the bottleneck, so that vehicles move with uniform speed, thereby creating a steadier flow of traffic. The performance measures (e.g. travel time, fuel consumption, and speed oscillations) of the probe vehicles were analysed. To evaluate the effectiveness of speed harmonisation on smoothing the flow of traffic, these measures were compared between the probe vehicles that followed the CAVs. The results show the potential that CAVs have in reducing the oscillatory behaviour of traffic.
Routing protocol for battery management system of electric vehicles based on ad‐hoc network
Authors: Song Jiajia , Zhang Jinbo , Fan Xinnan
Published: December 2017

The comprehensive performance of electric vehicles (EVs) and distribution of charging locations are two key factors restricting the development of EVs. An effective way to improve the performance of EVs is to manage the battery pack with a battery management system (BMS), while in the actual operation, the collection and analysis of the battery state parameters is of great significance to the study of BMS. It is necessary to detect and provide the location information of the nearest charging station, thus each vehicle is required to have network communication function because the vehicles may move in real time. The ad‐hoc technology is used to solve the network communication between the vehicles and the charging piles. There is no standard routing protocol for ad hoc, and the network routing protocol directly determines the efficiency, reliability and correctness of the network data transmission. Based on the cluster‐tree and ad‐hoc on‐demand distance vector junior (AODVjr) protocols, this study proposed a routing protocol suitable for mobile ad‐hoc network algorithm, and made a simulation on the NS2 platform. The results showed that compared with other protocols, the ad‐hoc routing protocol is more suitable for the application of this system.
Selective harmonic suppression strategy by SAPF in power distribution system
Authors: Cong Liu , Ke Dai , Xinwen Chen , Yuqing He , Pingjiang Lu
Published: December 2017

This study proposes a flexible selective harmonic compensation and resonance damping algorithm for shunt active power filter (SAPF) applied in three‐phase three‐wire power distribution system. The selective harmonic compensation current reference extraction is based on recursive discrete Fourier transform. The resonance damping control strategy adopts damping gain auto‐adjustment algorithm based on proportional–integral regulation of the point of common coupling (PCC) voltage total harmonic distortion. Theoretical analyses have shown that harmonic compensation together with resonance damping by the SAPF could obtain the best performance to improve the power quality of the power distribution system. Simulation and laboratory test results are provided to verify the effectiveness of the proposed strategy.
The seven sisters DANCe
Authors: Olivares J. , Moraux E. , Sarro L. M. , Bouy H. , Berihuete A. , Barrado D. , Huelamo N. , Bertin E. , Bouvier J.
Published: December 2017

Context. Membership analyses of the DANCe and Tycho + DANCe data sets provide the largest and least contaminated sample of Pleiades candidate members to date.

Aims. We aim at reassessing the different proposals for the number surface density of the Pleiades in the light of the new and most complete list of candidate members, and inferring the parameters of the most adequate model.

Methods. We compute the Bayesian evidence and Bayes Factors for variations of the classical radial models. These include elliptical symmetry, and luminosity segregation. As a by-product of the model comparison, we obtain posterior distributions for each set of model parameters.

Results. We find that the model comparison results depend on the spatial extent of the region used for the analysis. For a circle of 11.5 parsecs around the cluster centre (the most homogeneous and complete region), we find no compelling reason to abandon King’s model, although the Generalised King model introduced here has slightly better fitting properties. Furthermore, we find strong evidence against radially symmetric models when compared to the elliptic extensions. Finally, we find that including mass segregation in the form of luminosity segregation in the J band is strongly supported in all our models.

Conclusions. We have put the question of the projected spatial distribution of the Pleiades cluster on a solid probabilistic framework, and inferred its properties using the most exhaustive and least contaminated list of Pleiades candidate members available to date. Our results suggest however that this sample may still lack about 20% of the expected number of cluster members. Therefore, this study should be revised when the completeness and homogeneity of the data can be extended beyond the 11.5 parsecs limit. Such a study will allow for more precise determination of the Pleiades spatial distribution, its tidal radius, ellipticity, number of objects and total mass.
Metastatic Osseous Pain Control: Bone Ablation and Cementoplasty
Authors: Cornelis Francois , Tutton Sean , Filippiadis Dimitrios , Kelekis Alexis
Published: December 2017

Nociceptive and/or neuropathic pain can be present in all phases of cancer (early and metastatic) and are not adequately treated in 56 to 82.3% of patients. In these patients, radiotherapy achieves overall pain responses (complete and partial responses combined) up to 60 and 61%. On the other hand, nowadays, ablation is included in clinical guidelines for bone metastases and the technique is governed by level I evidence. Depending on the location of the lesion in the peripheral skeleton, either the Mirels scoring or the Harrington (alternatively the Levy) grading system can be used for prophylactic fixation recommendation. As minimally invasive treatment options may be considered in patients with poor clinical status or limited life expectancy, the aim of this review is to detail the techniques proposed so far in the literature and to report the results in terms of safety and efficacy of ablation and cementoplasty (with or without fixation) for bone metastases. Percutaneous image-guided treatments appear as an interesting alternative for localized metastatic lesions of the peripheral skeleton.
Palliative Percutaneous Biliary Interventions in Malignant High Bile Duct Obstruction
Authors: Deipolyi Amy , Covey Anne
Published: December 2017

The optimal palliative intervention for malignant biliary obstruction is internal drainage by placement of a metallic stent. For patients with hilar biliary obstruction or low bile duct obstruction in whom endoscopy is not feasible, a percutaneous transhepatic approach in interventional radiology is preferred. This article reviews the rationale for this approach, periprocedural management, and techniques to optimize stent patency.
Malignant Venous Obstruction: Superior Vena Cava Syndrome and Beyond
Authors: Friedman Tamir , Quencer Keith , Kishore Sirish , Winokur Ronald , Madoff David
Published: December 2017

Venous obstruction in the cancer population can result in substantial morbidity and, in extreme cases, mortality. While venous obstruction can be caused by both benign and malignant etiologies in this population, the management of malignant venous obstruction as a palliative measure can be somewhat nuanced with respect to nonprocedural and procedural management, both with respect to treatment of the underlying malignancy as well as treatment of venous hypertension, which may be associated with venous thrombosis. Symptom severity, primary malignancy, functional status, and prognosis are all fundamental to the patient workup and dictate both the timing and extent of endovascular intervention. The morbidity and mortality associated with malignant obstructions of central venous structures, specifically the superior vena cava and inferior vena cava, can be significantly improved with endovascular management in appropriately selected patients. Thus, the pertinent literature regarding the clinical presentation, workup, and endovascular management of malignant central venous obstruction syndromes, with directed attention to superior vena cava syndrome and inferior vena cava syndrome, will be reviewed in this article.
Are Trabecular Metal Cones a Valid Option to Treat Metaphyseal Bone Defects in Complex Primary and Revision Knee Arthroplasty?
Authors: Bonanzinga Tommaso , Gehrke Thorsten , Zahar Akos , Zaffagnini Stefano , Marcacci Maurilio , Haasper Carl
Published: December 2017

Purpose Metaphyseal bone defects are a challenge in complex primary and revision total knee arthroplasty (TKA). Recently, several studies have been published with promising results about the use of Trabecular Metal (TM) cones to address bone defects. The aim of this study is to review the literature to assess the efficacy of TM cones to address metaphyseal bone loss.

Methods A comprehensive search was performed on PubMed, Medline, CINAHL, Cochrane, Embase, and Google Scholar databases using various combinations of the following keywords: “metaphyseal,” “cones,” “tantalum,” “knee,” and “revision.” Only papers reporting clinical data about the use of trabecular metal cones were included in the analysis. In vitro studies, case reports, surgical technique, or other studies where it was not possible to collect clinical data were excluded. Patients characteristics, details of the surgical procedures, outcome, and complications were collected from each included study.

Results No controlled studies were available in the literature and all the papers were case series. In 16 studies included, the records of 442 patients with 447 implants and 523 TM cones were reported. The mean follow-up was 42 months (range: 5–105) for 360 procedures. Among 437 procedures, 30.4% were septic revisions. The Anderson Orthopaedic Research Institute (AORI) classification was available for 352 defects: 13 type 1, 69 type 2A, 115 type 2B, and 155 type 3. To manage these 352 defects, 360 TM cones were implanted. Intraoperative fractures occurred 13 times (10 femoral/3 tibial), 6 required surgical fixation. The overall infection rate was 7.38%, and the infection rate for the aseptic procedures was 0.99%. An aseptic exchange was performed 13 times, among these procedures two TM cones were loose. Signs of loosening were found just in 1.3% of the 523 TM cones implanted (5 femoral/2 tibial) during 447 procedures.

Conclusion The TM cones are an effective solution to manage bone defects in complex primary and revision TKA at intermediate follow-up. The incidence of complications was low; however, the femoral metaphysis proved to be more susceptible to complications.

Level of Evidence Level IV, systematic review of level IV studies.
Phenotypic and Genotypic Heterogeneity of RRM2B Variants
Authors: Zarrouk-Mahjoub Sinda , Finsterer Josef
Published: December 2017

Objectives Genotype and phenotype of RRM2B mutation have become increasingly heterogeneous. This review aims at summarizing recent advances concerning the genotypic and phenotypic variability of RRM2B mutations.

Method The review evaluated clinical and instrumental data of 82 patients carrying a mutation in the RRM2B gene reported in 18 publications with regard to onset, frequency, and type of clinical manifestations and genetic findings.

Results The review showed marked variety of clinical manifestations and marked variety of age at onset. Organs predominantly affected in RRM2B mutation carriers are the skeletal muscle, the brain, and the kidneys. Additionally affected may be the eyes, ears, endocrine organs, heart, gastro-intestinal tract, bone marrow, or the peripheral nerves. So far 43 mutations in 81 patients have been reported. Diagnosing RRM2B-associated disease requires demonstration of an appropriate phenotype and a RRM2B mutation. Various clinical manifestations are accessible to various invasive or noninvasive therapeutic measures. The outcome of RRM2B-associated mitochondrial disorders is highly variable ranging from early death to survival into adulthood.

Conclusions Phenotype and genotype in RRM2B mutation carriers are more widespread than anticipated. Particularly in patients with chronic progressive external ophthalmoplegia, ptosis, limb muscle weakness, muscle hypotonia, renal tubulopathy, ataxia, deafness, and lactic acidosis, a RRM2B mutation should be considered.
Embolization of Bleeding Pinna Arteriovenous Malformation after Ligation of the External Carotid Artery: A Therapeutic Challenge
Authors: Kumar Rahul , Goyal Ankur , Bhalla Ashu , Sandip Sonia , Sikka Kapil
Published: December 2017

A 25-year-old patient presented with bleeding of right pinna arteriovenous malformation (AVM). There was history of ipsilateral external carotid artery (ECA) ligation 10 years back. Subsequent investigations (ultrasound, magnetic resonance imaging, digital subtraction angiography) showed recruitment of complex collaterals from the ipsilateral subclavian artery and vertebral artery feeding the recurrent nidus. The patient underwent two sessions of endovascular embolization and one session of percutaneous embolization. We wish to highlight the feasibility of antegrade embolization in such cases via collaterals and role of direct percutaneous treatment.
Alkohol ist ein gefährliches Produkt
Authors: John Ulrich
Published: December 2017

Alcohol is a hazardous product. Its consumption depends on the society’s drinking norms. These are set by advertising industries on the one hand, and forces of public health and medical services on the other hand. Germany is one of the countries with high alcohol consumption. According to epidemiological evidence, alcohol-attributable diseases include more than 200 diagnostic entities. Medical practitioners may help to reduce alcohol consumption. Data revealed that brief intervention, including computer-generated feedback in medical practice, is efficient in reducing consumption. It relieves the physician of counseling responsibilities.
Pneumologische Rehabilitation bei chronisch-obstruktiven Atemwegserkrankungen
Authors: Schultz Konrad
Published: December 2017

Pneumologische Rehabilitation ist eine evidenzbasierte interdisziplinäre Behandlung für Patienten mit chronischen Erkrankungen der Atmungsorgane, die Symptome aufweisen und in ihren Berufs- und Alltagstätigkeiten eingeschränkt sind. Ziele sind neben der Sicherung der beruflichen und sozialen Teilhabe u. a. die Verbesserung der Symptome, der Leistungsfähigkeit, der Lebensqualität sowie die funktionelle Optimierung.