bluuebunny/crossref_metadata_2025 huggingface dataset:
A rare case of successful treatment for dual ectopic pancreas to the gastric wall in a child
Authors:   Tver State Medical University, Tver, Russian Federation, Rumyantseva G.N. , Kazakova E.I. ,   Tver State Medical University, Tver, Russian Federation, Yusufov A.A. ,   Tver State Medical University, Tver, Russian Federation, Brevdo Yu.F. ,   Children's Regional Clinical Hospital, Tver, Russian Federation, Minko T.N. ,   Children's Regional Clinical Hospital, Tver, Russian Federation, Trukhachev S.V. ,   Children's Regional Clinical Hospital, Tver, Russian Federation, Svetlov V.V. ,   Children's Regional Clinical Hospital, Tver, Russian Federation, Kazakov A.N. ,   Tver State Medical University, Tver, Russian Federation
Published: February 2022

In this article, we report a rare case of dual ectopic pancreas in a 12-year-old child. The patient was examined because of longterm pain and low weight. The endoscopic finding explained the cause of pain. To correct this malformation, we used laparoscopic resection. We provide a detailed description of the case history, clinical manifestations, results of laboratory and instrumental examination, stages of surgery, and pathological report. Kew words: ectopic pancreas in the stomach, children, laparoscopic resection
Serological proteome analysis in children born to mothers with gestational diabetes or type 2 diabetes mellitus
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Papysheva O.V. ,   S.S.Yudin City Clinical Hospital No 7 of the Moscow Department of Health, Moscow, Russian Federation, Kopylov A.T. ,   V.N.Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russian Federation,   Institute of General Pathology and Pathophysiology, Moscow, Russian Federation, Kaysheva A.L. ,   V.N.Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russian Federation, Kharitonova L.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kotaysch G.A. ,   Bauman State Clinical Hospital No 29 of the Moscow Department of Health, Moscow, Russian Federation, Mayatskaya T.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Krasheninnikova A.A. ,   Institute of General Pathology and Pathophysiology, Moscow, Russian Federation, Gribova I.E. ,   Institute of General Pathology and Pathophysiology, Moscow, Russian Federation, Morozov S.G. ,   Institute of General Pathology and Pathophysiology, Moscow, Russian Federation,   Bauman State Clinical Hospital No 29 of the Moscow Department of Health, Moscow, Russian Federation
Published: February 2022

Objective. Determination the impact of pregnancy course on the background of gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) on the serological proteome of children under 1.5 years of age. Patients and methods. Blood plasma samples of 110 children aged 1.35 ± 0.4 years old (Me = 1.27 years old, 46 boys, 64 girls) from mothers with a pregnancy occurring against the background of T2DM (n = 32) or GDM established for the first time (n = 42, of which 20 – from mothers with insulin-dependent therapy, 22 – from mothers with diet therapy) and 36 children of the control group were studied. The study was performed using a semiquantitative proteomic approach with consideration of serological markers representation, redundancy and statistically significant differences betweeb groups of the study. Results. Children born to diabetic mothers are differed from the control group by a small part of the proteome. The proteins AFM, GSN, APOA2, TF, SERPINA7, RBP4, ORM1, and some elements of the complement system were most affected by mothers diabetic condition. The hange in proteins abundancy ranged betwee 20-80%. There was no correlation with the treatment strategy for the GDM group of patients. Conclusion. The degree of quantitiative alteration in the children proteome depends on the mothers diabetic condition over the pregnancy. The most profound alteration were observed amongst serological markers indicating the risk of metabolic disorders, carbohydrate metabolism, protein glycosylation and associated processes of iron metabolism and extracellular matrix organization. Key words: gestational diabetes, type 2 diabetes mellitus, children's serum proteome
Opportunities of starting therapy for acute sinusitis in children
Authors:   Research and Clinical Center for Otorhinolaryngology of the Federal Medico-Biological Agency, Moscow, Russian Federation, Garashchenko T.I. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Karneeva О.V. ,   Research and Clinical Center for Otorhinolaryngology of the Federal Medico-Biological Agency, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Tulina A.S. ,   Research and Clinical Center for Otorhinolaryngology of the Federal Medico-Biological Agency, Moscow, Russian Federation, Serebryakova I.Yu. ,   Research and Clinical Center for Otorhinolaryngology of the Federal Medico-Biological Agency, Moscow, Russian Federation, Ahinyan A.O. ,   Research and Clinical Center for Otorhinolaryngology of the Federal Medico-Biological Agency, Moscow, Russian Federation
Published: February 2022

Acute sinusitis (AS) is one of the most common clinical manifestations of acute upper respiratory tract infection. Topical inflammatory therapy is an important component in the treatment of AS. Objective. To assess the efficacy and safety of Cinnabsin, a comprehensive homeopathic drug, in combination with topical decongestants in the treatment of acute sinusitis in children. Patients and methods. This study included 120 AS patients aged between 5 and 13 years. Study participants were divided into two groups (60 patients in each). Patients in Group 1 received xylometazoline and Cinnabsin. Patients in Group 2 received xylometazoline alone. Patients were followed-up for 26 days; during this time, they had 3 visits with a medical researcher. To evaluate the impairments of nasal breathing, we performed active rhinomanometry using the Otopront rhinomanometer. In addition to that, we assessed the transport function of the nasal ciliated epithelium. Conclusion. We found that Cinnabsin in combination with topical decongestants facilitated the recovery of nasal breathing. Key words: acute sinusitis, cinnabsin, nasal breathing, rhinometry
SPECIFICS OF PSYCHOLOGICAL STATUS OF LOCOMOTIVE CREW WORKERS WITH ARTERIAL HYPERTENSION
Authors:   Bashkir State Medical University, Russia, ALFUKAKHA MAKHMUD M.M. , MUTALOVA ELVIRA G. ,   Bashkir State Medical University, Russia
Published: February 2022

Introduction. Arterial hypertension is one of the most important problems of modern cardiology. Recently, special attention has been paid to the problem of early diagnosis and prevention of treatment of arterial hypertension in workers whose working conditions are associated with a stress-inducing factor causing psycho-emotional tension. Aim. Evaluation of psychological status in employees of locomotive crews with arterial hypertension was the aim of our study. Material and methods. 152 men working in the locomotive crews [mean age (43,2±5,1) years], including 88 patients with hypertension (main group) and 64 persons with normal blood pressure (comparison group) were examined. We performed anthropometric study with assessment of such parameters as waist circumference (cm), hip circumference (cm), calculated the ratio of body fat/hip, determined the parameters of lipidogram, blood insulin concentration, immunoreactive insulin, uric acid, and calculated the NOMA-IR index of insulin resistance. We used Spielberger–Hanin Scale, PSM 25 psychological stress scale, Internal Minute test, Reeder Scale of Psychological Stress, and DS-14 personality type diagnostic questionnaire to evaluate psycho-emotional status. The data were processed using standard statistical methods with Statistica 10 program, Microsoft Excel 2010. The differences were considered statistically significant at p<0,05. Results and its discussion. Changes in the indicators of psychological status, indicating a decrease in stress resistance and the development of stress reactivity, were revealed. Among patients with arterial hypertension there was a significantly higher proportion of individuals with a high level of personal anxiety, with a higher level of stress compared to the group of individuals without arterial hypertension. Conclusion. Patients with arterial hypertension working in locomotive crews are characterized by the presence of psychological status disorders, which are manifested by a high level of personal anxiety, stress, the development of «distressor» personality type D, and reduced stress tolerance. The degree of psychological disorders correlates with increased blood pressure level, age, and duration of stress factor exposure.
SPECIFICS OF THE STATE OF MYOCARDIUM AND PROFIBROTIC FACTORS IN THE DEVELOPMENT OF HYPERTENSIVE HEART
Authors:   Bashkir State Medical University, Russia, MUTALOVA ELVIRA G. , ALFUKAKHA MAKHMUD M. M. ,   Bashkir State Medical University, Russia
Published: February 2022

Introduction. Myocardial damage caused by arterial hypertension is manifested by changes in myocardial geometry and mass, as well as increased content of collagen and fibrous tissue in the myocardium. Excessive accumulation of collagen in myocardium is the result of imbalance between proteolytic enzymes such as matrix metalloproteinases 1 (MMP-1) and tissue inhibitors of matrix metalloproteinase 1 (TIMMP-1), high content of transforming growth factor β1 (TFG-β1), which was found in fibroblasts and macrophages. Aim. The aim of the study was to investigate the role of MMP-1 activation, its tissue inhibitor TIMMP-1 and TGF-β1 in blood in the development of myocardial fibrosis in locomotive train workers with arterial hypertension. Material and methods. 82 patients with arterial hypertension and 20 virtually healthy control subjects were examined. The patients of the analyzed groups underwent evaluation of the data of daily blood pressure monitoring, echocardiographic examination, based on which the types of left ventricular remodeling, the content of matrix metalloproteinase 1 and its tissue inhibitor activity, the level of transforming growth factor β1 in blood serum were identified. Calculation of the volume fraction of interstitial collagen was performed. Results and discussion. The study established statistically significant signs of structural changes in the left ventricular myocardium, which primarily indicated its marked left ventricular hypertrophy against the background of arterial hypertension due to chronic pressure overload. Statistically significant increase of all levels of serum markers of collagen metabolism was revealed in patients with arterial hypertension in comparison with the control group. Patients with arterial hypertension have a restructuring of the intercellular matrix components and imbalance in the MMP-1/TIMMP-1 system characterized by a shift of the collagen balance towards fibrosis (increase of THF-β1, TIMMP-1 level, decrease of MMP-1/TIMMP-1 52 ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2021 Том 14, вып. 6ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ ratio and increase of interstitial collagen volume fraction). Significant increase of interstitial collagen volume fraction index in the group of patients with arterial hypertension comparing to the control group also indirectly indicates high intensity of interstitial collagen genesis in myocardium of these patients. Conclusion. In arterial hypertension, serum levels of THF-β1, MMP-1, and TIMMP-1 increase, which indirectly indicates an increase in myocardial collagen content.
Muscle Tendon Transfers Around the Shoulder
Authors: Li Xinning , Galvin Joseph W. , Zalneraitis B. Holt , Gasbarro Gregory , Parada Stephen A. , Eichinger Josef K. , Boileau Pascal , Warner Jon J.P. , Elhassan Bassem T.
Published: February 2022

➤ Muscle tendon transfers (MTTs) are effective surgical procedures for reducing pain and for improving active shoulder range of motion and patient-reported outcomes for a wide range of pathologies, including serratus anterior and trapezius muscle palsy, irreparable subscapularis tears, irreparable posterosuperior rotator cuff tears, irreparable posterior rotator cuff tears in the setting of reverse shoulder arthroplasty, and symptomatic complete deltoid deficiency.

➤ The principles of MTT include ensuring that the transferred muscle is expendable, the muscle tendon unit has similar excursion, the line of pull of the transferred tendon and of the recipient muscle are similar in terms of biomechanical force, and the transferred muscle should replace at least 1 grade of strength of the deficient recipient muscle.

➤ When MTT procedures are considered, patients must have exhausted all nonoperative management, have preserved passive range of motion, and have an understanding of the postoperative expectations and potential complications.

➤ For patients with scapulothoracic abnormal motion (STAM) due to long thoracic nerve palsy, the indirect or direct pectoralis major tendon transfer is an effective procedure for reducing pain and improving active forward elevation. For patients with STAM due to spinal accessory nerve palsy, the Eden-Lange or the triple tendon transfer procedures reduce pain and improve active forward elevation and abduction as well as patient-reported clinical outcomes.

➤ Both pectoralis major and latissimus dorsi transfer procedures for isolated irreparable subscapularis deficiency without anterosuperior humeral head escape result in improvement with respect to pain, patient-reported outcomes, and forward elevation, with the pectoralis major tendon transfer demonstrating durable long-term outcomes.

➤ The latissimus dorsi or lower trapezius tendon transfer procedures for irreparable posterosuperior rotator cuff tears reliably improve patient-reported outcomes, forward elevation, abduction, and external rotation range of motion. Additionally, latissimus dorsi transfer with or without teres major transfer can be used to restore active external rotation, both in the native shoulder and in the setting of reverse shoulder arthroplasty.

➤ The complications of MTTs include infection, hematoma, and failure of tendon transfer healing; therefore, it is recommended that these complex procedures be performed by shoulder surgeons with appropriate training.
The Kalkowsky Project - Chapter III. Significance of primary radial fabrics associated with ancient partly leached or recrystallized calcareous ooids
Authors:   Association Carnets de Géologie, Granier Bruno , Lapointe Philippe
Published: February 2022

Calcitic ooids and bothryoids from the Yacoraite Formation in the provinces of Jujuy and Salta (Argentina) display radial fabrics pointing to their primarily high-Mg calcite (HMC) nature. The present publication documents some specimens that are partly or fully leached or recrystallized, which raises fundamental questions about the validity of some concepts, such as the very existence of the so-called "two-phase"/"bimineralic" ooids. It is assumed here that the organic content in the oolitic cortices (and, subsequently, its degree of oxidation) is the key to explaining some differential diagenetic alterations.
The Sound of One Fracture Flowing
Authors: Rassenfoss Stephen
Published: February 2022

In November 2020, Gustavo Ugueto had an extraordinary in-well experience. The source of his amazement was a stream of ﬁber-optic data measuring how fractures were altered by slight pressure changes during production.

When the principal petrophysicist for unconventional technology at Shell described the Permian well test, he sounded like someone who had used a stethoscope for the ﬁrst time.

“The straining is extended and compressed at all times like breathing,” Ugueto said during a presentation at the 2021 Unconventional Resources Technology Conference (URTeC) about the test done at the Fracturing Test Site 2 in late 2020 (URTeC 5408).

He said it was an “aha moment,” as was getting a good signal considering the inﬁnitesimal diﬀerences in the fracture dimensions in a well where the daily pressure drop was less than 40 psi.

And he was excited to think about what this test could reveal someday about how fractures change during production.

If it lives up to that potential, “we will have the ability to measure. We can experiment. What type of treatment? What type of proppant? We can do more of the good one and less of the bad one. The problem [now] is we have been working blind,” he said.

While he was clearly excited about the potential, he also repeatedly cautioned that there is so much more work required to learn what is possible. At this point, the few people with access to this data are like new medical students using a stethoscope, wondering how those sounds related to the patient’s health. “We are at the beginning of journey; it may fail,” Ugueto said.

The New Strain

The data from the Hydraulic Fracture Test Site 2 are only available now to those who backed the project, but three papers cover the work (see For Further Reading), sparking others to try this new way to measure fractures.

“Because of the publications by Gustavo and his coauthors, we are seeing a lot of uptake based on what was learned,” said Dana Jurick, Neubrex Energy Services US—the company that supplied the equipment used to measure the strain data. The company has since been hired for similar work by other oil companies curious about what they can learn from this new diagnostic.

The coauthors include Ge Jin, an associate professor at the Colorado School of Mines, who was a geophysics consultant at the Hydraulic Fracturing Test Site 2, and Kan Wu, an associate professor at Texas A&M, who is collaborating with Jin. Her group at Texas A&M is working on modeling aimed at turning this qualitative data source into a quantitative measurement.

Ugueto said other operators trying it, including Chevron and ConocoPhillips who were among the test site partners, plus other ﬁber-optic companies, are getting into a ﬁeld that is so new there is no settled name for it.

Two commonly used labels for it reﬂect varying levels of optimism about its future. One is based on the data gathered: near-wellbore strain analysis. The other is based on a vision where it is possible to measure how fractures react to change: near-wellbore fracture dynamics.
Experimental Analysis of Flow Characteristics and Annular Flow Boundaries of the Highly Viscous Oil/Water Lubricated Flow
Authors: Yin Ran , Jing Jiaqiang , Yuan Ying , Guo Yuying , Luo Jiaqi
Published: February 2022

Theoretical research on the characteristics of two-phase flow in horizontal pipelines is very important in the petroleum industry because a large amount of pumping power can be derived from the water-lubricated transportation of heavy or extraheavy crude oil. Experimental research of oil/water two-phase flow with water as the continuous phase in horizontal pipelines is carried out using tap water and two mineral oils with viscosity of approximately 0.743, 412, and 686 mPa·s, respectively. Two oil/water mixing devices of a water-ring generator and T-shaped three-way pipe are adopted to compare the effect of oil/water annular flow. Pressure drop parameters, apparent viscosity, clear pictures, flow pattern maps, and resistance characteristics of oil/water two-phase flow are displayed in this article, together with comprehensive comments. Moreover, obtained results are compared with theoretical findings, experimental results, and empirical laws of different scholars in the literature. According to the ratio of fluid kinetic energy (inertial force) to potential energy (buoyancy), Froude number (Fr) is introduced to reach the state of hydrodynamic lift balance. Based only on experimental observations of the position of the layered/annular transition, a novel criterion is proposed to determine the regions with suitable operating conditions for application.
Performance Evaluation of Demulsifier Using the Optimum Formulation HLD Concept: A Practical Case Using Heavy Crude Oil Diluted in Naphtha or in Synthetic Aromatic Oil
Authors: Meza L. , Alvarado J. G. , Márquez R. , Forgiarini A.
Published: February 2022

Asphaltene-stabilized water-in-oil (W/O) emulsions can cause severe problems during oil production and transportation. These emulsions are broken by adding a demulsifying agent at a suitable concentration (CD*) to obtain the optimal formulation, with minimal emulsion stability (stability*). Herein, we studied, from a phenomenological point of view, the performance of two demulsifiers on W/O emulsion breaking with high asphaltene content. A very simple polyethoxylated nonylphenol demulsifier (6EO) and a complex commercial demulsifier (COD) were studied. The influence of the chemical nature of the oil phase on the performance of the demulsifiers was evaluated. The emulsion stability* and CD* values of W/O systems of heavy crude oil diluted in cyclohexane (Systems A and B) were compared to W/O emulsions composed by a heavy crude oil diluted in heavy naphtha or in an aromatic synthetic crude oil as the oil phase (Systems C and D). The results show that demulsifier performance improves significantly when the crude oil is diluted in heavy naphtha and in aromatic synthetic crude oil, obtaining unstable W/O emulsions (rupture time of 10−2–10−1 minutes). In the latter cases, the CD* value is significantly lower and with a wide area of low emulsion stability compared to systems formulated with crude oil diluted in cyclohexane. The mechanisms that generate this type of behavior are discussed and strategies to increase performance and robustness analyzed.
Rock Physics-Based Data Assimilation of Integrated Continuous Active-Source Seismic and Pressure Monitoring Data during Geological Carbon Storage
Authors: Joon Shams , Dawuda Ismael , Morgan Eugene , Srinivasan Sanjay
Published: February 2022

There has been substantial controversy concerning the role of geological carbon storage (GCS) in sequestering anthropogenic carbon emissions to mitigate climate change and global warming. Arguments center on the inability to monitor a geological storage site precisely and continuously, especially highlighting the associated costs and spatiotemporal trade-offs when using conventional subsurface monitoring techniques (well logs, core samples, chemical tracers, and 4D seismics). Active surveillance of GCS sites is essential for managing and mitigating potential leaks but is also required by regulation. With the goal of enhancing the monitoring capability at GCS sites, we present a rock physics-based joint data assimilation model to study a popular GCS site at Cranfield, Mississippi, USA. Synthetic continuous active-source seismic monitoring (CASSM) data (in the form of Vp and Qp measurements) and wellbore pressure monitoring data are assimilated with an ensemble of reservoir realizations to monitor gas saturation and reservoir pressure changes over a period of 100 years. Synthetic seismic attributes are generated using rock physics models (RPMs) and wellbore pressure monitoring data are extracted from the ground truth. Two assimilation methods, ensemble Kalman filter (EnKF) and ensemble Kalman smoother (EnKS), are tested in an observation system simulation experiment (OSSE) environment to assess the prediction accuracy of the individual and composite observation systems. The joint monitoring system achieves more accurate estimates of gas saturation and pressure, across the time span from start of injection to end of forecast, as compared to a single type of monitoring tool and irrespective of data assimilation algorithm choice. These results indicate that jointly assimilated data from two types of sensors (in this case, crosswell seismic and downhole pressure) may lead to a more risk-reducing monitoring design. One would expect that more data, vis-à-vis inclusion of a new sensor type, will improve the accuracy of any GCS monitoring system. However, from a practical standpoint, one important question is whether such a gain in accuracy is worth the additional cost associated with the new sensor. This paper focuses on quantifying the gain in accuracy, such that a practitioner can answer this question.
Improving Fracture Complexity and Conductivity in Shale Formation with Calcite-Filled Natural Fractures by a Novel CO2-Assisted Fracturing: An Experimental Study
Authors: Zou Yushi , Zhang Shicheng , Ma Xinfang , Li Sihai
Published: February 2022

Given the advantages of using CO2 as a fracturing fluid to enhance unconventional oil/gas production and urge of carbon neutrality, CO2-assisted fracturing draws increasing attention in China recently. However, several critical issues related to this fracturing technology, such as the mechanism of hydraulic fracture (HF) growth, still need to be clarified. A novel CO2-assisted fracturing design, which can increase the HF complexity and conductivity, as well as improve the porosity/permeability of surrounding rock matrix, bedding planes (BPs), and natural fractures (NFs), was proposed. In the design, the carbonated water, formed by dissolving surpercritical CO2 in the slickwater, is used as the slug fluid to soften the calcite-sealed NFs that intersect with the precreated HFs. Subsequently, the slickwater is injected as the carrying fluid to dilate the NFs. To verify this design, a series of true triaxial fracturing simulations and static soaking experiments were conducted on the Longmaxi shale in Sichuan basin, China. Scanning electron microscopy results show that carbonated water, a weakly acidic fluid, can react vigorously with the carbonate-rich shale with time going on, thereby resulting in numerous dissolved pores with the diameter of dozens of microns. Eventually, the reaction between rock and carbonated water increases porosity/permeability and reduces mechanical strength. Notable dissolution of calcite, which could soften the calcite-sealed NFs, can occur in a short time (0.5 hours). Pretreating the specimen with carbonated water can lower the breakdown pressure of the rock by 2.7 MPa for half an hour and 11.7 MPa for 2 hours and promote HFs to propagate along the BPs and NFs in the shear-dominant mode. The shear dislocation and uneven erosion of fracture surface are of great significance in improving the permeability or conductivity of HFs. Notably, well shut-in for an optimized period may allow the sufficient interaction between carbonated water and shale, thereby improving the effectiveness of composite fracturing. This innovative design, which takes advantage of the special physical-chemical properties of supercritcal CO2, is feasible and conducive to enhancing production from unconventional reservoirs.
Estrogens and progestins cooperatively shift breast cancer cell metabolism
Authors: Ward Ashley V. , Matthews Shawna B. , Fettig Lynsey M. , Riley Duncan , Finlay-Schultz Jessica , Kabos Peter , Jackman Matthew , MacLean Paul S. , Sartorius Carol A.
Published: February 2022

Metabolic reprogramming remains largely understudied in relation to hormones in estrogen receptor (ER) and progesterone receptor (PR) positive breast cancer. In this study, we investigated how estrogens, progestins, or the combination, impact metabolism in three ER and PR positive breast cancer cell lines. We measured metabolites in the treated cells using ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS). Top metabolic processes upregulated with each treatment involved glucose metabolism including Warburg effect/glycolysis, gluconeogenesis, and the pentose phosphate pathway. RNA-sequencing and pathway analysis on two of the cell lines treated with the same hormones found estrogens target oncogenes such as MYC and PI3K/AKT/mTOR that control tumor metabolism, while progestins increased genes associated with fatty acid metabolism, and the estrogen/progestin combination additionally increased glycolysis. Phenotypic analysis of cell energy metabolism found that glycolysis was the primary hormonal target, particularly for the progestin and estrogen-progestin combination. Transmission electron microscopy found that, compared to vehicle, estrogens elongated mitochondria which was reversed by co-treatment with progestins. Progestins promoted lipid storage both alone and in combination with estrogen. These findings highlight the shift in breast cancer cell metabolism to a more glycolytic and lipogenic phenotype in response to combination hormone treatment, which may contribute to a more metabolically adaptive state for cell survival.
Nitric oxide detection using catalytic properties of CuCo-PTC metal-organic framework
Authors: Wang Meng , Dong Hui , Zhang Yintang , Zhou Yanli , Gu Mengjiao , Zhu Qianqian , Song Yiwen , Ye Baoxian , Xu Maotian
Published: February 2022

Nitric oxide is one of the atmospheric pollutants and an important gas messenger molecule in the human body, involved in many physiological and pathological processes. Therefore, detecting nitric oxide rapidly and accurately has been one of the popular topics in recent decades. In this study, we synthesized CuCo-PTC MOF materials using a solvothermal method based on the mechanism of triazole ring formation from o-phenylenediamine (OPD) and nitric oxide. The synthesized CuCo-PTC MOF materials show high sensitivity and good selectivity for detecting nitric oxide in vitro and in cell lysates. The results indicate the potential for applying this sensing strategy to detect nitric oxide in the internal environment.
Title: Advances in blood donor policies in relation to gay, bisexual and other men who have sex with men (gbMSM) and transgender populations as donors: A scoping review.
Authors: Gahagan Jacqueline , Haw Jennie , Butler-Foster Terrie , Falvey Conor , Phinney Jackie , Redden Marco , Jenkins Catherine
Published: February 2022

Background: Globally, the updating of donor policies in relation to gay, bisexual and other men who have sex with men (gbMSM), transgender, and gender diverse populations remains an important public health issue. The purpose of this scoping review was to determine how Canada and other OECD countries are addressing this issue in relation to plasma and whole blood donation policies. Methods: The scoping review included English-language peer-reviewed empirical studies from OECD countries from 1997 to 2020 to better understand the shifts in donor policies over this time period. Initial search criteria resulted in 3,974 abstracts and titles. Researchers reviewed abstracts according to eligibility criteria which yielded a total of 51 published studies for full review. Data charting was based on Arksey and O’Malley’s framework for scoping reviews. Results: Key considerations included the reliance on mathematical modeling and behavioural risk surveillance data as a means of continuing with the status quo in informing donor policies which continue to ban sexually active gbMSM from donating. In addition, there is a lack of focus on the unique concerns facing transgender, gender diverse, and racially diverse populations who may wish to donate whole blood or plasma. Conclusions: There is a growing international policy shift in reducing the lifetime donor ban and/or removing the ban for gbMSM to donate blood. More needs to be done to both clarify the rationale for such policies in the face of current scientific evidence and testing and to ensure inclusion of transgender, gender diverse, and racially diverse populations in the formation of policies and information about both whole blood and plasma donations. Finally, blood operators need to work more closely with diverse donor communities to ensure the approach taken is in keeping with the needs of gbMSM, transgender, and gender diverse populations.
Association Between Perceived Stress, Loneliness and Sleep Disorders Among Breast Cancer Patients: the Moderating Roles of Resilience
Authors: Ban Yue , Li Mengyao , Bai He , Liu Li , Gu Zhihui , Zhang Ke , Yang Chen xin , Wu Hui
Published: February 2022

Purpose: Sleep disorders are prevalent and often neglected among breast cancer patients. This study aimed to identify the association among perceived stress, loneliness, resilience and sleep disorders, and to further explore whether resilience could be a moderator in the association between perceived stress, loneliness and sleep disorders among Chinese female breast cancer patients.Methods: A cross-sectional study was conducted at a tertiary hospital in Anshan, China from October 2019 to October 2020. 492 valid questionnaires were collected. Patients were asked in response to the questionnaires including the Pittsburgh Sleep Quality Index, Perceived Stress Scale-10, the Three-Item Loneliness Scale and Resilience Scale-14. The association among perceived stress, loneliness, resilience and perceived stress/loneliness × resilience interaction with sleep disorders were examined by hierarchical multiple regression analysis. The interaction was visualized by using simple slope analysis. Results: In our study, 36.58% of the female breast cancer patients reported sleep disorders. Perceived stress and loneliness were related to sleep disorders. Resilience could moderate the relationship between them and sleep disorders. When resilience was higher, perceived stress and loneliness had a weaker impact on sleep disorders.Conclusions: There was a high prevalence of sleep disorders and this study implied an adverse effect of perceived stress, loneliness on the sleep quality. However, resilience could moderate the association between perceived stress, loneliness and sleep disorders. More positive psychological interventions should be integrated into the prevention of sleep disorders among cancer patients.
Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis
Authors: Li Xintong , Xie Yuandong , Su Shuoyao , Liu Zhe , Zhao Jia , Wen Dezhong
Published: February 2022

Background
Colorectal cancer (CRC) is, at present, the most frequently and most lethal gastrointestinal tract cancer, leading to significant mortality and a large global cancer burden. TSPEAR has been reported to associate with the development of human tooth and hair follicle morphogenesis. However, there is no study on TSPEAR in any cancers have been reported.
Methods
The information of TSPEAR gene expression in CRC was collected from TCGA database and GTEx. The Rt-qPCR and WB were used to compare the TSPEAR expression level between normal colon cells NCM-460 and human CRC cell lines, included SW-480, SW-620, HCT-116, Ht-29, and LoVo. Then, we performed the survival, gene function/pathway enrichment, and tumor immune infiltration analyses via using R packages and TIMER database.
Results
It was demonstrated that TSPEAR gene showed high expression in CRC tissue and cell lines and up-regulated expression correlating with a poor overall prognosis. Besides, the up-regulated TSPEAR was correlated with the M1 stage, CEA level, and residual tumor. Multivariate analysis further confirmed that TSPEAR remained an independent CRC patient-related risk factors, whereas gene function/pathway enrichment analysis indicated that it may can regulate Wnt, Hippo signaling pathway, as well as many cell metabolism activities. For immune infiltration, the expression level of TSPEAR was positively correlated with immune cells and showed a strong correlation with diverse immune marker sets, especially in COAD.
Conclusions
The results demonstrated that TSPEAR is possibly a clinically valuable predictive biomarkers for CRC patients, as well as associated with tumor infiltrating immune cells.
Continuous three-dimensional stress monitoring in roof of coal mines for investigating the rockburst control effect with hydraulic fracturing
Authors: Gao Hou , Zhao Wusheng , Chen Weizhong , Xie Peiyao , Zhong Kun , Qin Changkun
Published: February 2022

The occurrence of rockburst in coal mines is closely related to the three-dimensional stress in coal and rock mass. Through hydraulic fracturing measurements in roof, the three-dimensional stress in roof before and after hydraulic fracturing as well as during working face advancing was monitored, and the effect of hydraulic fracturing in roof on controlling rockburst was studied. The test results show that (1) after hydraulic fracturing, the three principal stresses in roof decreased remarkably, whose maximum reduction was about 20%, while the elastic strain energy in roof decreased by about 31% as well; (2) as the working face advanced, the three principal stresses in roof in front of the working face would increase continuously until reaching peaks and induce the strata fracture, and the variation of the elastic strain energy in roof was basically consistent with that of the magnitude of three-dimensional stress; (3) with hydraulic fracturing, the position of the peak stress moved from 11 m to 21 m in front of the working face, the peaks of the three principal stresses decreased, whose maximum reduction was about 32%, and the peak of the elastic strain energy in roof also significantly decreased by about 51%. The field investigation shows that hydraulic fracturing in roof can release the stress and elastic strain energy in coal and rock mass instantaneously, and will reduce the risk of rockburst; hydraulic fracturing in roof can be an effective pre-destressing method to reduce the stress and energy concentration in coal and rock mass during mining, and will prevent the risk of rockburst.
Genome-wide association studies revealed complex genetic architecture and breeding perspective of maize ear traits
Authors: Khatun Mita , Monir Md Mamun , Lou Xiangyang , Zhu Jun , Xu Haiming
Published: February 2022

Background: Maize (Zea Mays) is one of the world's most important crops. Hybrid maize lines resulted a major improvement in corn production in the previous and current centuries. Understanding the genetic mechanisms of the corn production associated traits greatly facilitate the development of superior hybrid varieties. Result: In this study, four ear traits associated with corn production of Nested Association Mapping (NAM) population were analyzed using a full genetic model, and further, optimal genotype combinations and total genetic effects of current best lines, superior lines, and superior hybrids were predicted for each of the traits at four different locations. The analysis identified 21-34 highly significant SNPs (–log10P > 5), with an estimated total heritability of 37.31-62.34%, while large contributions to variations was due to dominance, dominance-related epistasis, and environmental interaction effects ( 14.06% ~ 49.28%), indicating these factors contributed significantly to phenotypic variations of the ear traits. Environment-specific genetic effects were also discovered to be crucial for maize ear traits. There were four pleiotropic SNPs found for three ear traits: two for ear length and weight, and two for ear row number and length. Using the Enumeration method and the stepwise tuning technique, optimum multi-locus genotype combinations for superior lines were identified based on the information obtained from GWAS. Conclusions: Predictions of genetic breeding values showed that different genotype combinations in different geographical regions may be better, and hybrid-line variety breeding with homozygote and heterozygote genotype combinations may have a greater potential to improve ear traits.
Changes in oral function, swallowing function, and quality of life in patients with head and neck cancer
Authors: Ihara Yoshiaki , Kato Hirotaka , Tashimo Yuichi , Iizumi Yoshiki , Hukunishi Yuma , Sato Hitoshi , Shimane Toshikazu , Takahashi Koji
Published: February 2022

Background: Head and neck cancer (HNC) treatment can cause oral morbidities, such as oral dryness and dysphagia, affecting the patient’s quality of life (QOL). The relationship between oral functions and QOL in patients with early-stage HNC remains unclear. The aim of this study is to evaluate changes in the QOL of patients with early-stage HNC and identify factors that affect the QOL of these patientsMethods: In this prospective cohort study, 52 patients who underwent early-stage (T1/T2) HNC treatment were evaluated for their oral function, swallowing function, and the QOL score at baseline (BL) and 12 months after surgical treatment (12M). The participants were divided into two groups: patients who returned to the BL QOL score at 12M (RE; n=35) and those who did not (NR; n=17). Results: In total, 32.7% (17/52) patients with early-stage HNC did not return to the BL QOL score at 12M. There was no significant difference between the RE and NR groups regarding the oral and swallowing function. Moreover, oral and swallowing function of all patients returned to the BL at 12M. The NR group showed lower QOL scores than the RE group in the global health status, physical function, and “sticky saliva” parameters in the questionnaires.Conclusion: Restoration of the oral function is insufficient to improve the QOL of patients with early-stage HNC. The treatment of these patients should instead consider several factors that affect their QOL.
Model-free Phasor Image Analysis of Quantitative Myocardial T1 Mapping
Authors: Franssen Wouter M. J. , Treibel Thomas A. , Seraphim Andreas , Weingärtner Sebastian , Terenzi Camilla
Published: February 2022

Model-free phasor image analysis, well established in fluorescence lifetime imaging and only recently applied to qMRI T2 data processing, is here adapted and validated for myocardial qMRI T1 mapping. Contrarily to routine mono-exponential fitting procedures, phasor enables mapping the lifetime information from all image voxels to a single plot, without resorting to any regression fit analysis, and describing multi-exponential qMRI decays without biases due to violated modelling assumptions. In this study, we test the performance of our recently developed full-harmonics phasor method for unravelling partial-volume effects, motion or pathological tissue alteration, respectively on a numerically-simulated dataset, a healthy subject scan, and two pilot patient datasets. Our results show that phasor analysis can be used, as alternative method to fitting analysis or other model-free approaches, to identify motion artifacts or partial-volume effects at the myocardium-blood interface as characteristic deviations, or delineations of scar and remote myocardial tissue in patient data.
Web and Social Media Searches Highlight Menstrual Irregularities as a Global Concern in COVID-19 Vaccinations
Authors: Katz Ariel , Tepper Yoav , Eran Alal , Birk Ohad
Published: February 2022

Background
Delineation of public concerns that prevent vaccine compliance is a major step in generating assurances and enhancing the success of COVID-19 prevention programs. We therefore sought to identify public concerns associated with COVID-19 vaccines, as reflected by web and social media searches, with a focus on menstrual irregularities.
Methods
We used trajectory analyses of web and social media search data in combination with global COVID-19 data to reveal time-dependent correlations between vaccination rates and the relative volume of vaccine and period related searches.
Results
A surge of period and vaccine related google searches followed the commencement of vaccination programs in English speaking countries, and across the United States. TikTok users were more engaged in period problems in 2021 than ever before.
Conclusions
National and state-level correlations between COVID-19 vaccinations and online activity demonstrate a global major concern of vaccine-related menstrual irregularities. Whether it is a potential side effect or an unfounded worry, monitoring of web and social media activity could reveal the public perception of COVID-19 prevention efforts, which could then be directly addressed and translated into insightful public health strategies.
Identification of s9ap Used as an Endogenous Reference Gene in Qualitative and Real-Time Quantitative PCR Detection of Pleurotus eryngii
Authors: Wei Yuanmiao , Liu Yao , Li Ling , Xiang Shuna , Zhang Hanyue , Shang Ying
Published: February 2022

Pleurotus eryngii is a kind of edible fungi with good quality, and it is popular among consumers. At present, some adulterated wild edible fungi are available in the market. The rights and interests of consumers can be ensured by establishing a practical edible fungi detection system. Among the existing methods for detecting food adulteration, endogenous reference gene amplification is convenient and reliable. However, no ideal endogenous reference gene is available for P. eryngii. In this study, s9ap was screened as an endogenous reference gene through sequence alignment. Qualitative and quantitative PCR analysis of this gene was carried out in one P. eryngii variety and 18 other species. The detection limit of quantitative PCR was 400 pg, and no s9ap amplification products were detected in the 18 other species. This study confirmed that s9ap was an ideal endogenous reference gene for the detection of P. eryngii. This method was also suitable for processed food products.
Strain-ultrasensitive surface wrinkles for visual wearable optical sensor
Authors: Ma Tianjiao , Chen Shuai , Li Jin , Yin Jie , Jiang Xuesong
Published: February 2022

Wearable tactile sensors have found widespread applications in human health monitoring, motion monitoring, human-machine interaction, and artificial prostheses. Herein, we demonstrate a new and feasible strategy for wearable optical sensors based on surface wrinkles ultrasensitive to strain using a bilayer wrinkling system, in which the sensing mechanism is different from that of the traditional electrical sensors. The strain (\(\overrightarrow{S}\left(\epsilon , {\theta }_{S}\right)\)), the wrinkled topography (\(\overrightarrow{W}\left(A, {\theta }_{W}\right)\)), and the reflected optical signal (\(\overrightarrow{O}\left(\delta , {\theta }_{O}\right)\)) functions are correlated with each other, allowing simultaneous measurement of strain magnitude and direction due to the vector property of optical signals. In addition, interactively visualized detection of slight strain has been achieved by conspicuous structural color change, successfully amplifying the strain signal owing to the ultra-sensitivity of wrinkles and the nonlinearity of optical signal. The sensor also exhibits electrical safety and immunity to electromagnetic interference, and thus may find potential applications in detecting various complex slight strains, such as subtle human motion or object deformation.
Digital finance and greener emissions: An empirical analysis of cities in China
Authors: Zhou Cai , Zhou Jinghong
Published: February 2022

We match the city-level finance digitization data from the Peking University digital financial inclusion index with the industrial pollution emissions information to study the relationship between digital finance and industrial pollution emissions. After alleviating endogenous problems with our instrument variable, we found that the development of digital finance significantly mitigates industrial pollution emissions, and the coverage and depth of digital finance also have a significant impact on industrial pollution emissions mitigation. We explain the mechanism through green personal finance and individual awareness. First, green finance programs provided on Alipay encourage greener emissions. Second, digital finance directly affects individuals’ environmental awareness and daily behaviors. Our empirical results show an average of 17.3% decrease in the industrial pollution emissions caused by digital finance.