bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Calibration Matrices on 3D Monocular Object Detection: Filtering, Dataset Combination and Integration of Synthetic Data
Authors: Evain Alexandre ,   ESIGELEC, Technopole du Madrillet, Khemmar Redouane , Orzalesi Mathieu , Ahmedali Sofiane ,   ESIGELEC, Technopole du Madrillet,   SEGULA Technologies,   Universite d’Evry Val d’Essonne
Published: July 2024

In traditional 2D object detection, augmenting datasets typically enhances model precision. However, 3D estimations from a 2D image are dependent on the camera"s focal length, meaning that differences in focal length may undermine distance estimation, object dimension estimation, and subsequent 3D position estimation. In this article, we attempt to evaluate the impact of different calibration matrices on 3D monocular object detection. First, we assess the impact of different calibration matrices within the same dataset by comparing the performance of filtered, non-filtered, and normalized datasets using the NuScenes dataset as a base. Our results show that filtering the dataset to only keep images sharing the same focal lengths results in increased depth and dimension estimations but at the expense of the other metrics. Then, we investigate the impact of dataset combination on 3D monocular object detection, focusing on the integration of datasets with varying focal lengths and matrices. Leveraging the NuScenes dataset, this time augmented with additional synthetic data from GTA, we evaluate the efficacy of dataset combination in improving model performance across a range of metrics. Contrary to our initial expectations, incorporating additional datasets does not consistently result in 2D performance improvements depending on their visual appearance, but also does not always result in decreased 3D performance either, despite their different focal lengths providing the model with contradictory 3D visual information, as long as the data contained is accurately labeled, showing that dataset combination has the potential to improve 3D monocular object detection.
Genetic Subdivision Curve and Surface Reconstruction
Authors: Komar Alexander Komar ,   Institute of Computer Graphics and Knowledge Visualisation, Graz University of Technology, Austria, Riegler Marco , Preiner Reinhold , Augsdörfer Ursula ,   Institute of Computer Graphics and Knowledge Visualisation, Graz University of Technology, Austria,   Institute of Computer Graphics and Knowledge Visualisation, Graz University of Technology, Austria,   Institute of Computer Graphics and Knowledge Visualisation, Graz University of Technology, Austria
Published: July 2024

In this paper we employ a new genetic algorithm approach for CAD shape reconstruction, where a mathematical shape representation is reconstructed from point data. We reconstruct planar subdivision curves and 3D subdivision meshes from ordered input point data by fitting the corresponding subdivision control polygon or control mesh respectively, from which the smooth subdivision limit surfaces can be derived. For the reconstruction of curves the system estimates the number and position of control points required to approximate the curve closely. To reconstruct subdivision surfaces from points, the system determines a sequence of CAD operations which is subject to mutation in the course of a genetic optimization. We discuss implementation details of the proposed genetic algorithms and demonstrate our approach on a number of example data.
A novel silhouette extraction method for binary images based on the Wall-Follower algorithm
Authors: Aguirre-López Mario A. ,   Autonomous University of Chiapas, Faculty of Sciences in Physics and Mathematics, Izaguirre-Prado Omar Efraín , Soto-Villalobos Roberto , Hueyotl-Zahuantitla Filiberto ,   Autonomous University of Nuevo León, Faculty of Earth Sciences,   Autonomous University of Nuevo León, Faculty of Earth Sciences,   Cátedra CONAHCyT-UNACH
Published: July 2024

Silhouette extraction involves separating objects of interest from their background, which has several applications in image processing. Among the silhouette extraction techniques, contour tracing is commonly applied to images with a uniform background. This paper introduces a novel contribution to contour tracing techniques, utilizing the Wall-Follower Algorithm (WFA) to extract silhouettes with uniform backgrounds, or binary images. The algorithm is based on the analogy of a follower sequentially walking aside the external boundary of a wall, without separating a hand from it; then, the follower walks tagging silhouette pixels along the way until returning to the initial position and direction. Experimentation on vehicle technical drawings, satellite views of bodies of water and photographs of plants shows its effectiveness in producing high-quality silhouettes while showing some advantages over existing techniques. They include quickness in obtaining a solution, efficiency and ability to handle complex contours, and the option to simplify the results by reducing the percentage of saved points that trace the perimeter, based on object characteristics. The robustness of the algorithm suggests it as a promising alternative with diverse applications in image analysis, computer-aided design, and 3D object reconstruction, by extruding silhouettes, the latter being the main motivation for this contribution.
POTENSI PARIWISATA BERBASIS BUDAYA LOKAL DESA RAWABOGO, KECAMATAN CIWIDEY, KABUPATEN BANDUNG
Authors: Novel Nurillah Jamil Achmawati , Tresna Pratami Wulan
Published: July 2024

Fenomena dari tulisan ini adalah eksplorasi potensi pariwisata budaya berbasis budaya lokal di Desa Rawabogo, Kecamaran Ciwidey, Kabupaten Bandung. Tujuan program ini adalah untuk mengidentifikasi, mendokumentasikan, dan mengembangkan potensi pariwisata berbasis budaya lokal di Desa Rawabogo, Ciwidey, Kabupaten Bandung. Metode program ini terdiri dari tahapan perencanaan, FGD dengan stakeholder lokal, observasi lanjutan, wawancara dengan informan kunci, serta evaluasi data untuk menyusun profil potensi wisata budaya di Desa Rawabogo. Hasil dari program menunjukkan bahwa Desa Rawabogo memiliki potensi budaya yang kaya dalam bentuk ritual dan pertunjukan budaya yang menarik untuk pariwisata, tetapi belum sepenuhnya terdokumentasi atau dipromosikan secara optimal. Kesimpulannya adalah bahwa melalui keterlibatan masyarakat, dokumentasi yang lebih baik, dan promosi yang lebih luas, potensi pariwisata berbasis budaya lokal di Desa Rawabogo dapat dikembangkan lebih lanjut untuk mendapatkan pengakuan lebih luas dan manfaat ekonomi yang lebih optimal.
PEMETAAN KEBUTUHAN PEMBANGUNAN PERUMAHAN DAN PERMUKIMAN BAGI MASYARAKAT TERDAMPAK GEMPA DI KABUPATEN CIANJUR
Authors: Candradewini Candradewini
Published: July 2024

Kebutuhan tanah untuk relokasi perumahan bagi warga terdampak bencana gempa di Kabupaten Cianjur masih belum dapat memenuhi kebutuhan sebagaimana mestinya. Kegiatan PPM ini bertujuan sebagai salah satu upaya mengatasi masalah dalam rangka mengembangkan ilmu pengetahuan dan memenuhi kebutuhan masyarakat. Metode PPM yang dilakukan oleh penulis adalah Participatory Action Research (PAR). Berbagai kebijakan terkait pembangunan perumahan dan permukiman telah disosialisasikan kepada berbagai stakeholders. Hasilnya, kebutuhan pembangunan perumahan dan permukiman bagi masyarakat terdampak gempa di Kabupaten Cianjur masih belum terpenuhi secara maksimal. Hal ini terlihat dari masih adanya kebutuhan tenaga kerja dan bahan bangunan dalam pembangunan hunian tetap, penyediaan tanah untuk relokasi, keselamatan bangunan, Rencana Kontigensi, dan dokumen atau SOP penanganan bencana. Kesimpulannya Pemerintah Kabupaten Cianjur berusaha memenuhi kebutuhan tersebut dengan berbagai cara, di antaranya dengan pembangunan Hunian Tetap (Huntap). Namun, upaya tersebut masih perlu ditingkatkan agar kebutuhan masyarakat terdampak gempa dapat terpenuhi secara maksimal.
Administración de riesgos. Volumen VIII. Ensayos sobre modelos, mercados y riesgos financieros
Authors: Sánchez Cantú Leopoldo , Carmona Muñoz Diana Milena , Martínez Vázquez David Conaly , Bucio Pacheco Christian , Sosa Castro Miriam , Ortiz Edgar , Rodríguez Nava Abigail , Arriaga Navarrete Rosalinda , Domínguez Gijón Rosa María , Téllez León Isela Elizabeth , Benavides Perales Guillermo , Venegas Martínez Francisco , Allou Alphonse Allou , Martínez García Miguel Ángel , Trejo García José Carlos , Solís Tepexpa Sergio , Muñoz González Luis Fernando , Martínez Preece Marissa del Rosario , Zubieta Badillo Carlos , Henaine Abed Mariem
Published: July 2024

Desde 2019 ya se vislumbraba un panorama económico y financiero incierto, y se proyectaban diversos escenarios que abarcaban desde una desaceleración de la economía mundial para 2020, hasta una fuerte recesión debido a factores como: incremento en los déficit fiscales, tanto en naciones desarrolladas como emergentes; inestabilidad cambiaria, incertidumbre y volatilidad en los mercados financieros, caída en los precios del petróleo y un descenso en el volumen del comercio internacional y la actividad industrial, entre los principales indicadores. Sin embargo, ningún pronóstico previó que la inestabilidad económica y financiera sería provocada por una crisis sanitaria como lo es la pandemia del COVID-19. Se prevé que la economía mundial se recuperé durante 2021, a medida que el confinamiento y restricciones de movilidad de la población desaparezcan y conforme se intensifiquen las campañas de vacunación. Ante este panorama, es de esperarse que exista inestabilidad económica y financiera en los próximos años. Por tanto, el estudio de la situación financiera nacional e internacional, a través de los mercados e instrumentos financieros, y los riesgos financieros y económicos inherentes a su operación bajo condiciones de incertidumbre, continúan siendo temas de estudio prioritarios. Considerando lo anterior, este volumen está integrado por tres partes que tratan diversos enfoques sobre modelos, mercados y riesgos financieros. En la primera parte se presenta una reflexión crítica de uno de los principales modelos utilizados en las finanzas, el modelo de fijación de precios, CAPM. La segunda parte, trata la volatilidad de los mercados bursátiles de países miembros del Mercado Integrado Latinoamericano, MILA, los mercados petroleros y el mercado cambiario. En la última parte se analizan distintos tipos de riesgos financieros en diferentes contextos y mercados.
How to deal with the side effects of long-term pharmacotherapy with aromatase inhibitors?
Authors: Jagiełło-Gruszfeld Agnieszka
Published: July 2024

Aromatase inhibitors are effective drugs used in adjuvant therapy of breast cancer. Their action is to reduce the level of oestrogens produced in adipose tissue in women in physiological or pharmacologically induced menopause. Nevertheless, long-term pharmacotherapy with aromatase inhibitors may lead to various side effects that may significantly affect the quality of life of patients. The following article presents the most common problems associated with aromatase inhibitor therapy and describes how to deal with these undesirable side effects.
INOVAÇÃO E METODOLOGIA EM STARTUPS: ANÁLISE DAS ESTRATÉGIAS DE DESENVOLVIMENTO DE PRODUTO E OPERAÇÕES NO ECOSSISTEMA EMPREENDEDOR DE PERNAMBUCO
Authors: Delmondes Fabiana Azevedo
Published: July 2024

Este estudo de caso explora a visão das Startups, em um ecossistema de inovação em Pernambuco, quanto à adequação das metodologias existentes para auxiliar a estruturação do modelo de negócio e sua relação com a tecnologia que deu origem ao seu produto ou serviço. Objetivo- Entender se as startups consideram que metodologias atuais as atendem frente aos diferentes tipos de tecnologia com os quais inovam. Foi realizado um estudo de caso múltiplo de uma Incubadora de Startup X de Pernambuco e startups de seu ecossistema empreendedor, por meio de um Survey, estudo bibliográfico e de mercado. 94% dos respondentes afirmam inovar em mais de uma área do modelo de negócio, e 78% que a inovação possui mais de um eixo central de tecnologia. 67% informaram que 2 ou mais metodologias foram utilizadas na formação da startup. Os aspectos onde as metodologias foram suficientes para orientar as ações da equipe de sócios/fundadores foram: entender as necessidades do cliente (89%) e estruturar a estratégia de desenvolvimento do produto ou serviço (78%). Os aspectos em que as metodologias foram consideradas deficientes foram: estruturar o funcionamento das operações da startup (39%), seguido por estruturar a estratégia de branding, estruturar a estratégia de captação de investimentos e estruturar a estratégia de modelo de receita da startup (todos com 33% das respostas). Os dados demonstram uma alta tendência entre as startups participantes da pesquisa de inovar em diferentes áreas do modelo de negócios e de utilizar inovações que possuem diferentes eixos centrais de tecnologia. Não foram encontradas evidências de que haja maior dificuldade em realizar a segmentação do mercado em virtude do tipo de tecnologia que está sendo utilizada. Por outro lado, outros aspectos, como estruturar as operações, podem não estar tendo uma construção facilitada pelas metodologias de formação de startup. Os dados parecem indicar que quanto maior o custo do desenvolvimento tecnológico sem observar a real demanda de mercado, mais difícil se torna adequar esta tecnologia a uma demanda não identificada anteriormente.
OTIMIZAÇÃO DE PROCESSOS GERENCIAIS ADMINISTRATIVOS EM UMA IES TECNOLÓGICA MEDIADA PELA FILOSOFIA LEAN THINKING
Authors: De Souza Natália Ramos , Ribeiro Rosinei Batista , Heringer Benedita Hirene De França
Published: July 2024

A esfera administrativa de uma IES (Instituição de Ensino Superior) Tecnológica contempla importantes processos gerenciais que impactam na sua estrutura organizacional, como o arquivamento e a emissão de documentos institucionais, atendimentos, organização dos espaços pedagógicos, entre outros aspectos fundamentais à uma rotina saudável desse tipo de Instituição. Entretanto, alguns desafios podem ser encontrados no intuito de manter esse alicerce administrativo fortalecido e dentre eles está a execução das tarefas rotineiras de forma eficiente. Quando não há uma padronização que promova organização estrutural da rotina administrativa, a execução dos processos pode se tornar desmotivadora. Considerando este o problema da pesquisa, este trabalho teve como objetivo otimizar os processos gerenciais administrativos da Faculdade de Tecnologia de Cruzeiro-SP. Como metodologia, utilizou-se a Design Science Research, resultando na proposição de um artefato (planilhas eletrônicas on-line) para otimizar quatro situações da IES estudada: 1. reservas de ambientes; 2. emissão de documentos institucionais; 3. atividades ocorrentes aos finais de semana e feriados na faculdade; e 4. cumprimento de demandas da equipe gestora, evidenciadas na etapa de desenvolvimento, por meio das abordagens do Design Thinking e do Lean Thinking, envolvendo todos os setores, inclusive as empresas terceirizadas, na resolução das problemáticas encontradas. Após análise dos resultados, concluiu-se que o objetivo foi alcançado, pois com a implementação e implantação do artefato o fluxo de trabalho ganhou uma nova e positiva perspectiva em aspectos estruturais e interpessoais.
Human-Centric Assistive Technologies in Manual Picking and Assembly Tasks: A Literature Review
Authors: LUCCHESE Andrea , MUMMOLO Giovanni
Published: July 2024

In the current industrial context, the human workforce still represents a key resource thanks to its cognitive and motor flexibility. The present work explores the role of Industry 4.0 assistive technologies in production and logistics systems from a human-centric perspective. These technologies aim to provide cognitive or physical support to operators executing manual tasks, rather than substituting them. Therefore, there is need for a comprehensive understanding of the impact of assistive technologies on the well-being and performance of operators from a human-centric perspective. In this paper, a literature review on available assistive technologies is provided. Technologies are classified based on the type of manual task (picking, assembly), type of support provided to the operator (cognitive, motor), and potential drawbacks. Outcomes emphasize the need of a thorough human-centric perspective in developing and deploying assistive technologies.
Towards Green Industrial Development in Ukraine: A Decision Model for Post-Industrial Production Strategies
Authors: BUZHYMSKA Kateryna , VYHOVSKYI Volodymyr , SOTNYK Anhelina , SVITLYSHYN Ihor , BILIAK Tetiana
Published: July 2024

The issue of modelling decision-making in the field of green production in a post-industrial society determines the relevance of the study. The main goal of the study is to develop a decision-making model that can help green industry organizations identify optimal strategies and actions to reduce environmental impacts, ensure sustainable efficiency, and promote development. The methodology used in the study involved a theoretical analysis, synthesis, and mathematical modelling methods. As a result, an innovative mathematical model was developed and proposed, which allows predicting the influence of various factors when choosing the optimal production strategy. The results show that the application of the developed model allows Ukrainian enterprises in the field of green production to determine optimal strategies aimed at reducing the environmental impact of production processes on the environment. It helps to ensure sustainable production efficiency, contributing to the economic sustainability of enterprises and the global economy.
Green Logistics Practices Toward a Circular Economy: A Way to Sustainable Development
Authors: Verma Amitabh
Published: July 2024

This research investigates the effects of green logistics practices on the sustainability performance of manufacturing enterprises in Oman, with a particular focus on the mediating role of circular economy practices. Analyzing data from 220 manufacturing companies through the PLS-SEM method, the findings reveal that green logistics management significantly enhances an organization’s sustainability and adherence to circular economy principles. Notably, while supply chain trackability greatly impacts circular economy practices, it does not moderate the relationship between sustainable performance and green logistics. This study enhances the understanding of how green logistics can support sustainable development and the implementation of circular economy practices in the manufacturing sector
Revitalizing Indonesian Tourism: Insights from Gunungkidul Regency's Communication Strategy
Authors: Asmara Shenja Nanta , Salim Mufid , Adhitya Galant Nanta , Marta Rustono Farady , Hariyanti Nunik , An Nur Fitrinanda
Published: July 2024

Tourism is a crucial part of Indonesia's economy, thanks to the country's natural beauty and attractions. However, the COVID-19 pandemic has presented significant challenges to the sector, requiring innovative strategies to revive it. This study examines the communication strategy of the Gunungkidul Regency Tourism Office, focusing on how it navigates the complexities of the new normal era. The study uses a qualitative descriptive approach and centers on the Gunungkidul Regency Tourism Office. Data was gathered through observation and documentation of tourist sites and interviews with tourism officials, site management personnel, and tourists from June to July 2021. The study found that the Gunungkidul Regency Tourism Office diligently adopted key communication strategy phases, including audience profiling, message formulation, method selection, and media choice. They also provided fundamental components of tourism development, such as attraction, accessibility, amenities, and ancillary, to cater to tourist demands. The strategy emphasizes effective communication to engage diverse stakeholders, using audience segmentation and engagement and multimedia platforms to ensure maximal outreach and resonance. The findings highlight the importance of crisis communication best practices, audience segmentation, and evaluating tourism community resilience, which are essential for crafting a resilient and sustainable tourism ecosystem.
User-Generated Content and Cultural Public Relations Approach to the Virtual Branding of Lombok Tourism
Authors: Tarmidzi Nur'aeni , Dasrun Hidayat  , Zikri Fachrul Nurhadi  , Reza Rizkina Taufik
Published: July 2024

Information about tourist attractions is the right of tourists protected by tourism laws and consumer protection. One approach used to fulfill consumer information is through User Generated Content (UGC). This approach serves as virtual branding activities to promote tourist attractions. The content presented must be able to attract visitors' interest. Therefore, there needs to be an effort by tourism managers to provide facilities and tourism infrastructure to ensure visitor comfort. The experiences of tourists will become content published on social media or applications used in User Generated Content (UGC) activities. The purpose of this research is to analyze the motives behind visitors' communal experiences and to analyze the challenges faced by tourism managers in dealing with User Generated Content (UGC) activities. This study uses a qualitative method with a phenomenological approach. The results obtained indicate that the main motive consciously and collectively built for UGC is to share useful information about tourist attractions through citizen journalism activities. Other results show that the challenges faced by tourism managers in dealing with UGC activities include enhancing facilities, improving tourism accessibility, and increasing cooperation to generate more UGC content by actively involving the community through local activities. One successful example of cooperation is through empowering local residents in the traditional weaving handicraft activities typical of Lombok, which are part of the Micro, Small, and Medium Enterprises (MSMEs).
Model Pengeluaran Rumahtangga Peternak Ayam Broiler Di Kecamatan Tenayan Raya Kota Pekanbaru Provinsi Riau
Authors: Elinur Elinur , Heriyanto Heriyanto , Bakce Djaimi , Arief Wahyudi Hajry , Rahmadani Elfi
Published: July 2024

Household expenditure is the amount of money used by households to meet household consumption. This study aims to analyze the characteristics of broiler farmers, the structure of household income and expenditure, and analyze the factors affecting broiler farmers household expenditure. This study uses a survey method. The sampling method used simple random sampling with a total sample of 56 broiler farmers. There are 4 findings in this study. First, the age of the broiler farmers is productive with a high school education level. They are experienced in their business. Second, the structure of broiler farmers household income consists of broiler business income and non-farm income. Broiler business income has a large contribution to household income. Third, household expenditure consists of food and non-food expenditure. Non-food expenditure has the largest share of household expenditure. Fourth, significant dominant factors affecting household expenditure are household income, number of family members, savings and household assets. However, farmer's education does not significantly affect household expenditure
Increasing Red Onion Production on a Household Scale Using Coconut Water and NPK as a Growth Stimulant
Authors: Ardian Ardian , Syafrinal Syafrinal , Nurbaiti Nurbaiti , Zuhry Elza , Kurnia Sari Lisa , Lubis Nursiani
Published: July 2024

Red onion (Allium ascalonicum L.) is a horticultural plant needed by household consumers as a complement to cooking spices and traditional medicines. Shallot production does not meet market demand in Riau, so it is necessary to bring in shallots from other regions. Efforts to increase shallot production continue to be made to meet market demand in Riau. One of the efforts that can be made to increase the production of shallot plants is through the use of natural growth hormones (ZPT). This research aims to determine the respective effects and interactions of giving concentrations of coconut water and NPK fertilizer on the growth and yield of shallot production. This research is a factorial experiment prepared using a completely randomized design (CRD) consisting of 2 factors, namely the concentration of coconut water and the dose of NPK fertilizer. Factor I: Coconut water concentration which consists of 4 levels, namely: A0 = without coconut water, A1 = 50% coconut water (500 ml coconut water + 500 ml water), A2 = 75% coconut water (750 ml coconut water + 250 ml water) and A3 = 100% coconut water (1000 ml coconut water). Factor II: NPK fertilizer dose consisting of 3 levels, namely: N1 = NPK 125 kg.ha-1, N2 = NPK 250 kg.ha-1, and N3 = NPK 375 kg.ha-1. . Data from the analysis of variance were further tested using Duncan's multiple range test at the 5% level. The research results showed that the combination of coconut water with a concentration of 100% and NPK fertilizer with a dose of 250 kg.ha-1 increase plant height, increase tuber diameter, increase fresh tuber weight per m2 and weight of storable tubers per m2.
Respons Pertumbuhan dan Hasil Tanaman Tebu (Saccharum officinarum L) Ratoon 2 Terhadap Kombinasi Zeolit dan Persentase Pupuk N
Authors: Kusumastuti Any , Indrawati Wiwik , Aziz Abdul , Zaqyah Irene , Ayu Afifah Dian , Apsoni Rapi
Published: July 2024

Tebu (Saccharum officinarum L.) adalah tanaman yang dibudidayakan untuk diolah menjadi gula. Namun, sampai saat ini Indonesia menjadi negara pengimpor gula karena tidak mampunya industri gula memenuhi kebutuhan dan permintaan gula yang terus meningkat serta tingginya harga jual dalam negeri, sehingga diperlukan impor gula untuk memenuhi kebutuhan gula di Indonesia. Untuk menanggulangi hal tersebut adalah dengan melakukan pemupukan Nitrogen pada tanaman tebu yang dikombinasikan dengan bahan pendamping berupa Zeolit. Penelitian ini bertujuan untuk mendapatkan pertumbuhan dan hasil tanaman tebu ratoon 2 dengan pemberian Zeolit dan persentase pupuk N serta interaksi antara Zeolit dan persentase pupuk N. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) disusun secara split plot dengan dua faktor perlakuan yang diulang sebanyak 3 kali dengan 6 kombinasi perlakuan sehingga didapatkan 18 satuan percobaan. Petak utama dosis Zeolit dengan Z₀ adalah tanpa zeolit dan Z₁ adalah zeolit 700 kg.ha⁻¹ (setara dengan 0,8 kg.8m kairan⁻¹). Anak petak persentase dosis pupuk N dengan P₁ adalah 100% urea (setara dengan 0,36 kg. 8m kairan⁻¹), P₂ adalah 80% urea (setara dengan 0,28 kg. 8m kairan⁻¹), dan P₃ adalah 60% urea (setara dengan 0,21 kg. 8m kairan⁻¹). Hasil penelitian ini menunjukkan pemberian dosis Zeolit berpengaruh terhadap seluruh parameter variabel pengamatan pertumbuhan yang meliputi tinggi tanaman, diameter batang, dan jumlah ruas. Serta hasil tanaman yang meliputi bobot batang, panjang batang, nilai brix dan rendemen. Pemberian Persentase dosis pupuk N tidak memberikan pengaruh terhadap pertumbuhan dan hasil tanaman tebu. Tidak terdapat interaksi antara dosis Zeolit dan persentase dosis pupuk N terhadap pertumbuhan dan hasil tanaman tebu
Inovasi Pengembangan Kulit Macaron Menggunakan Tepung Kacang Hijau (Vigna radiata L.) Dengan Tepung Almond dan Penambahan Serbuk Black Mulberry (Morus nigra Sp.)
Authors: Taufik Yusman , Gozali Thomas , Nurminabari Ina Siti , S Ashifa Zahra
Published: July 2024

The aim of this study was to obtain the results of the ratio of mung bean flour with almond flour and the addition of black mulberry powder on the characteristics of macaron shell.This research consists of two stages, namely preliminary research and main research. Preliminary research was conducted to make mung bean flour and black mulberry powder and then analyzed. The main research used a 3x3 factorial Randomized Block Design (RAK) with 3 replications. The treatment design consisted of two factors, namely the factor of the ratio of mung bean flour to almond flour (T) consisting of 3 levels (70:30), (60:40) and (50:50) and the factor of adding black mulberry powder (B) consisting of 3 levels 0%, 1% and 2%. The responses in this study consisted of chemical responses namely moisture content, ash content, fat content and protein content, physical responses of swelling power and color intensity, and organoleptic responses namely color, aroma, taste and texture attributes The results showed that the ratio of mung bean flour to almond flour had an effect on moisture content, ash, fat, protein, swelling power, color intensity (L* a* b* value), hedonic attributes of color, aroma, taste and texture. The addition of black mulberry powder had a significant effect of swelling power, color intensity (L* a* b* value), hedonic attributes of color, aroma, taste and texture. The interaction between the ratio of mung bean flour with almond flour and the addition of black mulberry powder had an effect of swelling power, color intensity (L* a* b* value), hedonic attributes of color, aroma, taste and texture.
Síndrome de Burnout em médicos: estudo epidemiológico de suas causas
Authors: Fink Marcela do Souto , Moreira Juliana Iamamoto Cuzziol , Noguti Julia Mari , Hoyer João Henrique de Oliveira , Sapata Rafael Costa Pereira , Igari Victor Ken
Published: July 2024

Objetivo: O estudo visa analisar a suscetibilidade ou não de fatores epidemiológicos no acometimento dos médicos pela Síndrome de Burnout. Métodos: A pesquisa foi realizada através da resposta de 84 médicos aos questionários virtuais, sendo um deles o Maslach Burnout Inventory (MBI) que investiga a incidência da síndrome, e o outro é um formulário de pesquisa para traçar o perfil epidemiológico dos voluntários. Resultados: A amostra apresentou a maioria feminina (68,75%), casadas (56,25%) e com 2 a 3 filhos (43,75%), com 25 a 30 anos de idade (25%), sendo a maioria dos indivíduos com 21 anos ou mais de formação em medicina (43,75%) com tempo de assistência médica também de 21 anos ou mais (43,75%), com a maior carga horária apontada de 31 a 41 horas semanais (43,75%), trabalhando em mais de uma instituição de saúde (75%) e a maioria em instituições públicas (62,50%) dos pesquisados. Conclusão: A Síndrome de Burnout é um problema significativo que atinge o médico e o serviço de saúde, sendo necessário ações preventivas e intervenções que visem a minimizar seus impactos.
Capacitação para futuros professores no controle de grandes hemorragias
Authors: Rodrigues Niélesse Máximo Ferreira , Riedo Ariadne de Oliveira , Cordeiro Thais Lazaroto Roberto , Castro João Gustavo de
Published: July 2024

Objetivo: Capacitar acadêmicos de graduação sobre o controle de grandes hemorragias utilizando da técnica de simulação clínica. Métodos: Pesquisa de campo, descritiva e qualitativa, realizada com acadêmicos dos cursos Licenciatura em Pedagogia e Português/Inglês de uma instituição de ensino superior privada no estado do Paraná. Para coleta de dados, foi ministrado um minicurso, aplicados pré e pós-testes, instrução, avaliação de habilidades técnicas, utilizando simulação clínica e checklist. Além disso, realizou-se avaliação de satisfação e entrevista, visando compreender a perspectiva dos estudantes em relação à capacitação. A análise dos dados foi conduzida por Bardin (2016), além da análise de variáveis comparativas, apresentadas por meio de tabelas e gráficos. O estudo foi submetido e aprovado pelo Comitê de Ética em Pesquisa. Resultados: Participaram 26 estudantes, obteve boa aceitação e melhoria significativa de desempenho nas habilidades. As entrevistas destacaram duas categorias empíricas: "Da teoria à prática o impacto do treinamento baseado em simulação clínica na educação" e "Salvando vidas como professores: a importância do treinamento em primeiros socorros para futuros docentes". Conclusão: Observou-se um aumento significativo no conhecimento dos participantes. A capacitação foi eficaz, dinâmica, didática, apresentação de cenários diversos e uma sensação de realidade.
Entraves que permeiam a Atenção Primária à Saúde para o manejo e controle da doença de Chagas no Brasil
Authors: Silva Aldemes Barroso da , Barroso Daiana Clara Bueno de Sousa Brandão , Fonseca Sara da Silva Siqueira , Freitas Simone Patrícia Carneiro de , Santos Jéssica Pereira dos , Mallet Jacenir Reis dos Santos
Published: July 2024

Objetivo: Discutir sobre os entraves que permeiam na Atenção Primária à Saúde para o manejo e controle da doença de Chagas no Brasil. Revisão bibliográfica: Apesar dos avanços e dos impactos das atividades de prevenção e controle da doença de Chagas adotadas no âmbito das políticas no Brasil, imensas lacunas ainda persistem e reforçam o quão negligente é a doença. Considerações finais:  As barreiras supracitadas até aqui demonstram, em parte, um desinteresse das agendas políticas em assumir e/ou implantar ações mais eficazes relacionadas à doença de Chagas que por sua vez, tem sido atropelada por programas e doenças de maior visibilidade, talvez pela longa evolução clínica da doença e pelas características das populações comumente atingidas que possuem baixa expressão social. Os pacientes acometidos carecem de representatividade e de maior acesso às redes de assistência do Sistema Único de Saúde permanentes e qualificadas em todos os níveis de atenção. Somente quando grandes reformas políticas, sociais, ambientais e educacionais estiverem articuladas efetivamente é que a doença de Chagas será caracterizada como uma enfermidade controlada no país.
Off-Label Uses of Upadacitinib
Authors: Amara Shivkar , Sapoznik Ariana , Guenin Sophie , Kodali Nilesh , Lebwohl Mark
Published: July 2024

Background: Janus Kinase (JAK) inhibitors interfere with the JAK-STAT signaling pathway, which is vital in regulating inflammation and immune function. Notably, upadacitinib, a JAK inhibitor, has been increasingly used as a treatment modality for refractory inflammatory diseases.
Methods: A literature review was conducted on Pubmed and Clinical Trials.gov using the keywords “upadacitinib” combined with “off-label”, “dermatology”, “skin”, or “cutaneous” from October 1st, 2021, to October 1st, 2023. 941 articles were reviewed, and 50 articles were included.  
Results:  The systematic search revealed 20 different dermatology conditions treated with off-label use of upadacitinib. Most of these conditions showed drastic improvement by actively decreasing the inflammatory response involved in the pathogenesis of that condition. The most common side effects reported for the medication were elevated creatine kinase, headaches, urinary tract infections, and acne. Patients should also be advised to consider the shingles vaccines prior to upadacitinib treatment.
Conclusion: Upadacitinib shows potential utility in the treatment of refractory inflammatory dermatologic conditions, treatment-resistant pruritus, and medication-induced skin reactions. Further large-scale, controlled clinical trials are needed to evaluate the further indications of upadacitinib and its safety profile.
The Effect of Platelet Rich Plasma (PRP) Plus Microneedling Versus Tranexamic Acid Plus Microneedling in the Biometric Characteristics of Melasma: A Before-After, Assessor Analysis, Blinded, Clinical Trial
Authors: Roohaninasab Masoumeh , Nilforoushzadeh Mohammad Ali , Ebrahimi Zahra , Goodarzi Azadeh , Abouei Abolfazl , Ziaeifar Elham , Zare Sona , Nouri Maryam , Mozafarpoor Samaneh
Published: July 2024

Background: Melasma is a chronic, acquired, focal pigment disorder showing symmetrical hyperpigmentation or hypermelanosis of photo-exposed areas on the face. Tranexamic acid (TXA) is a treatment for melasma. The regression of melasma after platelet-rich plasma (PRP) treatment is an interesting finding.
Objectives: To evaluate the effect of PRP plus microneedling vs. tranexamic acid plus microneedling on the quality of melasma.
Methods: This is a left-right split-face comparison study with 18 patients with melasma. The patients underwent four sessions of PRP plus microneedling and tranexamic acid (5%) plus microneedling on right and left sides of the face, respectively, at monthly intervals. Evaluations were performed before the start of treatment and one month after the last treatment session.
Results: Totally, 20 female patients with melasma were included with a mean age of 41 years (range: 34-49 years). Five participants had Fitzpatrick phototype II, eleven had phototype III, and others had phototype IV skin. Both TXA + microneedling and PRP + micro-needling caused a significant reduction in the Tewameter measurement (mean difference PRP =-3.33, P=0.003, and mean difference TXA =-2.15, P=0.003). In addition, the median delta E in the patients who received both treatments was significantly decreased after the treatment (mean difference =6.66, P<0.001 in TXA + microneedling group; mean difference =1.90, P<0.001 in PRP + microneedling group). The patients who received TXA + microneedling showed a significant reduction in melanin mexameter measurement. The patients were satisfied with both treatments.
Conclusion: This study showed that PRP and tranexamic acid with microneedling have a significant effect in reducing the MASI score and are considered an effective treatment. Although none of these two methods was superior over the other one, they can be a good combination or alternative for the treatment of melasma because they have good efficacy, safety, tolerability, and satisfaction among patients.
What Do Clinicians Mean When Submitting a Biopsy as “Rule Out Eczema”
Authors: Nguyen Kaycee , Cockerell Clay
Published: July 2024

Background: “Eczema” encompasses many dermatological conditions and usually manifests with spongiosis histologically. Dermatopathologists often receive biopsy specimens with requests to “rule out eczema.” However, this broad term is limiting and lacks the necessary clinical context for precise diagnoses.
Objective: This study explored the conditions implied by “rule out eczema” when rendered by clinicians and whether they regard it as synonymous with atopic dermatitis or other spongiotic conditions. Understanding this distinction is vital for guiding appropriate treatment which differs among disparate conditions appearing similar histologically.
Method: 63 clinicians (54 dermatologists, 5 physician assistants, 4 nurse practitioners) completed a web-based questionnaire. Participants identified conditions considered when requesting to “rule out eczema,” who completed requisition forms, and whether they modify automated EMR phrases to specify these conditions.
Results: 83% (52/63) included atopic dermatitis in the differential diagnosis, with “rule out eczema” also referencing nummular eczema (65%), dyshidrotic eczema (54%), contact dermatitis (51%), neurodermatitis (22%), and seborrheic dermatitis (14%). Other conditions included mycosis fungoides, psoriasis, and tinea infections. Most forms were completed by medical assistants (51%) or dermatologists (43%). 81% were modified from the suggested EMR diagnosis before submission.
Conclusion: Because “rule out eczema” is nonspecific and conditions may not be readily distinguished with histology alone, it’s recommended that the phrase be discarded in favor of specifying which disorder the clinician is presumptively diagnosing clinically. Because nonspecific phrases such as “dermatitis unspecified” generated by EMR programs are of limited value, it is not recommended to provide these options for clinicians when submitting biopsy specimens.
Efficacy of Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 (TYK2) Inhibitor, in Scalp Psoriasis by Baseline Psoriasis Area and Severity Index (PASI) and Baseline Body Surface Area (BSA): A Subanalysis of the Phase 3 Clinical Trial Data
Authors: Blauvelt Andrew , Sofen Howard , Lambert Jo , Merola Joseph F. , Lebwohl Mark , Hoyt Kim , Banerjee Subhashis , Scharnitz Thomas , Crowley Jeffrey J.
Published: July 2024

Introduction: Deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, is approved in the US, EU, and other countries for treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy. Deucravacitinib was effective and well tolerated in the global, 52-week, phase 3 POETYK PSO-1 (NCT03624127) and POETYK PSO-2 (NCT03611751) trials. Here, efficacy of deucravacitinib in scalp psoriasis was evaluated by baseline severity of psoriasis in the trial patients with scalp involvement.
Methods: Patients with moderate to severe scalp involvement (scalp-specific Physician Global Assessment [ss-PGA] ≥3) at baseline were included in this analysis. Efficacy outcomes (ss-PGA 0/1 and Psoriasis Scalp Severity Index [PSSI] 90) were reported through Week 24 (pooled PSO-1/PSO-2, before PSO-2 rerandomization, n=514) and Week 52 (PSO-1, continuous deucravacitinib treatment, n=192). Outcomes were stratified by baseline PASI score 12-<15 (low) or ≥15 (high) and baseline BSA involvement 10%-≤15% (low) or >15% (high).
Results: ss-PGA 0/1 response rates were high and slightly greater in the high versus low PASI subgroup at Week 24 (65.8% and 58.3%, respectively) and Week 52 (73.5% and 60.0%). Similarly, PSSI 90 response rates were high and also somewhat greater in the high versus low PASI subgroup at Week 24 (55.3% and 45.8%) and Week 52 (66.0% and 53.3%). Across the 2 baseline BSA subgroups, ss-PGA 0/1 and PSSI 90 response rates were comparable at Weeks 24 and 52.
Conclusion: Deucravacitinib treatment was effective in patients with scalp involvement in psoriasis regardless of overall baseline disease severity.
Low Occurrence of Predefined Safety Events Across Six Randomized Clinical Trials of Spesolimab in Dermatologic Conditions
Authors: Gordon Kenneth , Eyerich Kilian , Anadkat Milan , Choon Siew Eng , Elewski Boni , Barker Jonathan , Mostaghimi Arash , Tang Ming , Haeufel Thomas , Thoma Christian , Thaci Diamant
Published: July 2024

Introduction In the randomized, placebo-controlled Effisayil 2 trial, the anti-interleukin (IL)-36 receptor antibody spesolimab demonstrated a reassuring safety profile when given over 48 weeks for flare prevention in patients with generalized pustular psoriasis (GPP). Nevertheless, given its novel mechanistic approach, it is important to characterize events relating to IL-36 inhibition with spesolimab as well as those of potential relevance to an intravenously/subcutaneously administered biologic.
Methods In this analysis, rates of such predefined events – severe/serious/opportunistic infections, potential hypersensitivity reactions, peripheral neuropathies, and malignant tumors – were examined using available data from six randomized trials of spesolimab across various dermatologic conditions.
Results Events reported in patients receiving spesolimab at various doses and schedules in two trials in GPP, two in palmoplantar pustulosis (PPP), one in atopic dermatitis (AD), and one in hidradenitis suppurativa (HS) were included (total n=345 for spesolimab and 145 for placebo). Exposure to spesolimab was: GPP, 244.3; PPP, 327.8; AD, 40.0; and HS, 45.7 patient-years, respectively. Rates of severe/serious/opportunistic infections were low with spesolimab (3.2% in one GPP trial; otherwise, 0% vs. 0% with placebo), and the incidences of hypersensitivity reactions were similar for spesolimab (7.7–33.3%) and placebo (5.6–44.4%) across trials. There was one report of peripheral neuropathy with spesolimab in a PPP trial (incidence 0–0.9% across trials) versus two (one GPP, one PPP) with placebo (0–3.3%), and one malignancy with spesolimab in GPP (0–1.1% across trials) versus one with placebo in PPP (0–2.3%).
Conclusion These results support the favorable safety profile of spesolimab seen in Effisayil 2.
Tapinarof Cream 1% Once Daily is Efficacious for the Treatment of Atopic Dermatitis in Patients with Skin of Color Down to 2 Years of Age in Two Pivotal Phase 3 Trials
Authors: Alexis Andrew F. , Kircik Leon , Chovatiya Raj , Rice Zakiya P. , Bhutani Tina , Brown Philip M. , Piscitelli Stephen C. , Rubenstein David S. , Tallman Anna M. , Armstrong April W.
Published: July 2024

Introduction: Patients with atopic dermatitis (AD) and skin of color can have heterogeneous presentations and treatment responses. In the pivotal phase 3 ADORING 1 and 2 trials, tapinarof cream 1% (VTAMA®, Dermavant Sciences, Inc.) once daily (QD) was significantly efficacious and well tolerated versus vehicle in adults and children down to 2 years of age with AD.
Objective: Here, we report analyses of efficacy by skin color in ADORING 1 and 2, based on patients’ self-identified race and investigator-assessed Fitzpatrick skin type.
Methods: In ADORING 1 and 2, patients with a Validated Investigator Global Assessment for Atopic DermatitisTM (vIGA-ADTM) score of ≥3, an Eczema Area and Severity Index score of ≥6, and body surface area involvement of 5–35% were randomized 2:1 to tapinarof cream or vehicle QD for 8 weeks. The primary efficacy endpoint was a vIGA-ADTM score of 0 (clear) or 1 (almost clear) and ≥2-grade improvement from baseline at Week 8. Secondary endpoints included proportion of patients with a ≥75% improvement in Eczema Area and Severity Index (EASI75).
Results: Of the 407 and 406 randomized patients, 8.8–15.3% were Asian, 26.5–35.0% were Black, 44.8–56.8% were White, and 2.7–5.2% were Other groups (American Indian or Alaska Native, Native Hawaiian or Pacific Islander, or multiple races) across trials. Patients with Fitzpatrick skin types IV, V, and VI represented 23.8–25.1%, 20.6–22.2%, and 7.6–8.9%, respectively, of patients (>50% in both trials). Across trials, vIGA-ADTM responses (ranges) for tapinarof versus vehicle were: Asian, 39.5–48.9% vs 3.7–18.5%; Black, 43.1–47.0% vs 17.5–24.1%; White, 49.4–52.1% vs 12.2–14.5%; and Other, 26.0–44.8% vs 0.0–40.2%. EASI75 responses for tapinarof versus vehicle were: Asian, 47.6–76.6% vs 17.7–20.2%; Black, 48.9–55.3% vs 25.7–30.0%; White, 61.4–67.8% vs 19.6–20.7%; and Other, 38.3–63.3% vs 0.0–40.6%. Similarly, high and consistent vIGA-ADTM and EASI75 responses were reported with tapinarof versus vehicle in patients with Fitzpatrick skin types I–III and IV–VI.
Conclusion: Tapinarof cream 1% QD was consistently efficacious among all racial groups and Fitzpatrick skin types in adults and children down to 2 years of age with AD, including patients with skin of color, who were highly represented in these trials.