bluuebunny/crossref_metadata_2025 huggingface dataset:
İlk Dönem Kelâmî Tartışmaların Hadis Şerhlerindeki Yansımaları
Authors: Uzundağ Mehmet Sait
Published: February 2025

Hadis şerhlerinin bir taraftan önceki ilmî mirasın aktarılmasına diğer taraftan da ilmin yeniden üretilmesine imkân veren dinamik bir karaktere sahip oldukları bilinen bir husustur. Bu bakımdan aslında şerhlerde bir taraftan ilk dönemin izlerine, tartışmalarına rastlanmakta öte taraftan bu bilgilerin ilk dönem tartışmalarına ışık tuttuğuna şahit olmaktayız. Şerh kitaplarının salt yorumsal içeriğe sahip tekdüze eserler olmadığını ve ilmî açıdan dinamik bir yapıya sahip olduğunu gösteren bir diğer dikkat çeken husus ise şârihlerin itikâdî konularla ilgili rivayetleri şerh ederken görüşlerine katılmadıkları kişi veya gruplara karşı bazen de sert bir üslup kullanmak suretiyle onları tenkit etmeleridir. Bu yönüyle bakıldığında şerhlerde reddiye niteliğinde ciddi açıklamaların olduğu görülmektedir. Bu da bizi aslında tam olmasa da kısmen şerhlerin de bir yönüyle Ehl-i Hadis’in red literatürü arasında sayılabileceğini göstermektedir.rnAnahtar Kelimeler: Hadis, Kelam, Hadis Şerhleri, Kelâmî Tartışmalarrn---------------rnIt is a well-known fact that hadith commentaries possess a dynamic character, facilitating both the transmission of previous scholarly heritage and the reproduction of new knowledge. In this context, one can observe traces and discussions from the early periods within these commentaries, while also noting how this information sheds light on the debates of those early times. Another noteworthy aspect, which demonstrates that commentary works are not merely monotonous texts with interpretative content but rather possess a dynamic scholarly structure, is the approach of the commentators when explaining reports related to theological issues. At times, they adopt a harsh tone to criticize individuals or groups with whom they disagree. From this perspective, it becomes evident that certain commentaries contain substantial rebuttals. This suggests that, although not entirely, commentaries can partially be regarded as part of the refutation literature of the Ahl al-HadithrnKeywords: Hadith, Kalam, Hadith Commentaries, Theological Debates
Using Art as a Pedagogical Tool for Improving English Vocabulary Learning among 5th Graders
Authors: Pineda Herrera Yolanda de Jesus , Troya Sanchez Miriam Eucevia
Published: February 2025

The teaching of the English language is of great importance for elementary school children; however, the traditional methods used for teaching vocabulary have made it difficult for students to acquire new knowledge. The objective of this study is to evaluate the effectiveness of art as pedagogical tool for improving English vocabulary learning in fifth grade students of a public institution in the city of Loja, Ecuador. A quantitative method was used, with the use pre-test and post-test and a questionnaire was implemented at the end of the intervention to gather data on the students’ perceptions of the use of the art as a pedagogical tool to improve the participants’ vocabulary. The data obtained in these evaluations revealed a positive increase in vocabulary, going from a pretest of 4.77/10 to 9.02/10 (p < 0.001) in the post-test in the dimensions related to use, form and meaning. On the satisfaction level, most students perceived the arts activities as beneficial. The findings show that the implementation of art-based activities has a positive impact on English language vocabulary acquisition, demonstrating by paired t-test a statistically significant difference between pretest and posttest results. Therefore, it is recommended that educators integrate arts activities into English vocabulary instruction and conduct further research to validate these results in broader contexts.
Innovative, Multidisciplinary Management of Home Parenteral Nutrition Patients
Authors:   CarepathRx, Bezjak Johanna , Szabo Kayla , Tokarski Rebecca
Published: February 2025

Background
The total number of home parenteral nutrition patients in the United States grew steadily from 2011-2015 based on data from the American Society for Parenteral and Enteral Nutrition National Patient Registry for Nutrition Care. In the absence of an active national registry, some sources estimate 40,000 patients in the U.S. are prescribed home parenteral nutrition. The role and necessity of pharmacists within multidisciplinary nutrition support teams is described in numerous domestic and international studies, yet outpatient-based nutritional care for home patients is underrepresented in the literature. This descriptive analysis investigated the value of specially trained home infusion pharmacists and their roles in the management of home parenteral nutrition. The clinical initiative we describe introduces a unique partnership and shared service between 2 practice sites within an integrated health delivery system.

Implementation
A board-certified nutrition support pharmacist from the health-system home infusion pharmacy was embedded within the hospital-based clinic for approximately 30 hours a week. Pharmacist activities occurred under the oversight of the ordering physicians and included adjustment of fluid, electrolyte, macronutrient, and micronutrient content for intravenous therapies; general laboratory result monitoring and ordering; nutritional assessment; medication reconciliation; and patient education. In the scope of the agreement, pharmacists provided direct patient care without the participating providers’ written or oral consent based on practice guidelines, patient-specific factors, and clinical judgment. Drug therapy management duties included adjustment of the drug regimen, strength, frequency, and route.

Conclusion
After a pilot program, pharmacists from a health-system home infusion pharmacy worked within a hospital-based clinic, managing a large home parenteral nutrition patient population. While the pharmacists are employed by the health-system home infusion pharmacy, they continue to interact with patients as an extension of the physician office. The success of the position resulted in the development of a collaborative practice agreement.
Working environment and employee performance in local governments in Uganda; case study: Soroti Municipal Council
Authors:   ,   Uganda Martyrs University, Akiteng Winnie Brelly
Published: February 2025

The study sought to examine the effect of working environment on employee performance in Soroti Municipal Council. The specific objectives were; to determine the effect of physical working environment on employee performance, to examine the effect of staff support supervision on employee performance and to find out the effect of work incentives on employee performance. This study adopted a descriptive survey design so as to have a detailed study of fundamental themes, with a population of 205 people and the sample size of 136 people, however, 116 finally participated giving a response rate of 85.3%. Respondents were selected through purposive and simple random sampling; thereafter they were given questionnaires, while management participated in key informant interviews. The findings of the study indicated that physical working environment significantly affects employees’ performance by 22.7%. This implies that the enhancement of the general physical environment translates into an improvement in the employees’ performance. For objective 2: findings indicated that support supervision significantly affects employees’ performance by 28.8%. This implies that support supervision positively affects employee performance, as indicated by supervisors guiding and closely working with their subordinates to ensure that their performance is measurable. Objective 3: the study indicated that work incentives significantly affect employees’ performance by 35.2%. This is a testament that institution of work incentives like salary improvement, fringe benefits, promotion, recognition among others induce employees to commit themselves to the organization the more. Multiple regression analysis indicates that up to r 2 = 0.390 (39%), was accounted for by the independent variables included in the model. This shows that working environment is a strong correlate and predictor of employee performance. The study concluded that the three dimensions of working environment, namely; physical working environment, support supervision and work incentives are strong correlates and predictors of employee performance. In light of the findings, the researcher recommended that, the physical working environment needs to be made responsive to employees’ performance needs, Soroti Municipal Council needs to come up with guidelines on staff support supervision and the management should examine and improve the existing Human Resource procedure on disbursing fringe benefits and promotion opportunities which can motivate employees to be more committed to their work and also perform better by: giving priority to internal staff to compete in vacant positions before announcing to external applicants, disbursement of fringe benefits and transparency of promotion function.
Against Ecological Crisis: Sustain Life Through Lens of Ramayana
Authors: Singh Anil Kumar ,   Professor Sri Aurobindo College (E) University of Delhi, Singh Shipra ,   Associate Professor Delhi School of Professional Studies and Research. (Affiliated to Guru Gobind Singh IndraprasthaUniversity, Dwarka, Delhi
Published: February 2025

The whole emphasis of Indian Vedic philosophy is the human connection with nature. The Vedas,
Upanishads, Puranas, and the Epics of Rāmāyana and Mahābhārata have numerous instances
of worshiping the divine nature. These scriptures contain some of the earliest messages of
environmental protection, ecological balance and the necessity of treating Mother Nature ethically.
The interaction between nature and human beings is very much apparent throughout Ramayana.
The very first incidence which forms the central metaphor of the epic begins with “A hunter kills
one of the two birds in love and Vālmīki curses the hunter”. This suggests the importance that has
been attached to the preservation of life in forests. None was entitled to kill any animal or bird
unless it was absolutely necessary.
The world of Ramayana and Mahabharata being blessed with the richness of nature reminds us of
our place and role in the Great Nature in addition to our duties towards such human collectivities
as family, village and society. Ramayana defines not only the relationship but also the ecological
wholeness that has promoted millions of plants, animals, and other life forms. This paper advocates
that spiritually-based motives are needed to save humankind from the escalating ecological crisis
in this country. A deeper and broader view embracing our inner commitment is very much needed
in the present time.
IoT Based: Landslide and Flood
Detection System
Authors:   Electronics  Telecommunication, PESs Modern College of Engineering, Pune, India, Badiger Gouri , Gaikwad Sanghmitra , Kulkarni Shreya , Kodgirwar Vidya
Published: February 2025

The IoT- grounded Landslide and Flood discovery system employs detectors and IoT technology to cover and prognosticate landslides and cataracts in real time. It provides early warning signals to help disasters. Detectors, including rain detectors and vibration detectors and rain hand are placed strategically in vulnerable areas. Data is transmitted wirelessly via protocols like Wi-Fi or cellular networks to a pall-grounded platform, where real- time analysis reveal implicit pitfalls.
CICHORIUM INTYBUS (BEEKHE KASNI):A COMPREHENSIVE ANALYSIS OF TRADITIONAL, PHARMACOLOGICAL, AND NUTRITIONAL ASPECTS
Authors: Khan Hamda Tanzeem , Sidra Siddiqui  , Syed Tahir Ali  , Sana Siddiqui  , Muhammad Akhlaq  , Muhammad Khaleeq Alum
Published: February 2025

Background: Cichorium intybus L., commonly known as chicory, is a perennial herb of the Asteraceae family with a long-standing history of use in traditional medicine. Originating from Africa and parts of Eurasia, it has been used to treat various health conditions, including liver disorders, digestive ailments, and inflammatory diseases. Its high inulin content has gained significant attention for its role in managing blood glucose levels, particularly benefiting individuals with diabetes.
Body: This review explores the traditional applications, phytochemical composition, pharmacological activities, and nutritional value of Cichorium intybus. The plant exhibits a wide range of therapeutic effects, including antimicrobial, anthelmintic, antimalarial, hepatoprotective, antidiabetic, gastroprotective, anti-inflammatory, analgesic, antioxidant, and antitumor activities. Key bioactive compounds, such as sesquiterpene lactones concentrated in the roots, have been identified as potential agents for drug development. Despite its established safety profile, concerns regarding the toxicity of certain compounds at high doses highlight the need for regulated consumption.
Conclusion: While preclinical studies support its therapeutic potential, clinical trials remain limited but suggest possible benefits in managing joint pain and promoting cardiovascular health. The plant’s adaptability and inulin yield position it as an economically valuable crop for sustainable agriculture. Further research is necessary to validate traditional uses, explore its pharmacological potential, and develop standardized medicinal applications.
Trade, Taxation and the State: Interrelationships between Economic Networks and State Power in Ancient India
Authors:   सहायक आचार्य,  राजकीय कन्या महाविद्यालय बूढ़ा जोहड़, श्री गंगानगर., Singh Gurpal,
Published: February 2025

यह शोध पत्र प्राचीन भारतीय राज्यों के निर्माण और विस्तार में व्यापार, कराधान और क्षेत्रीय नियंत्रण के बीच के आपसी संबंधों का अध्ययन करता है। यह जांचता है कि कैसे आंतरिक और बाह्य व्यापार नेटवर्कों ने मौर्य और गुप्त साम्राज्यों जैसे प्रमुख साम्राज्यों के विकास को बढ़ावा दिया, और कैसे कराधान प्रणालियाँ राज्य प्रशासन और सैन्य अभियानों का समर्थन करती थीं। यह पत्र राजस्थान की भूमिका पर भी ध्यान केंद्रित करता है, जो क्षेत्रीय व्यापार का एक केंद्रीय हब था, और इसके स्थानीय राजपूत राज्यों पर प्रभाव और क्षेत्रीय प्रभुत्व के लिए अपनाई गई आर्थिक रणनीतियों का विश्लेषण करता है। राज्य सत्ता की आर्थिक नींव की जांच करते हुए, यह पत्र वाणिज्य और राजनीतिक अधिकार के बीच परस्पर संबंध को उजागर करता है, यह दिखाते हुए कि कैसे व्यापार राजस्व सैन्य अभियानों और प्रशासनिक संरचनाओं के वित्तपोषण में अनिवार्य था। यह अध्ययन प्राचीन भारत में राजनीतिक प्रणालियों के विकास में व्यापार की स्थायी धरोहर के बारे में अंतर्दृष्टि प्रदान करता है और आर्थिक इतिहास और राज्य निर्माण के क्षेत्र में भविष्य के अनुसंधान के लिए दिशाएँ सुझाता है।
Artificial Intelligence-Based Teaching Practice of College Art and Design
Authors:   School of Art, Pingdingshan Polytechnic College, Yuan Haolei
Published: February 2025

The new situation of social and economic development in China today is increasingly demanding the ability of art and design, and the connotation of art and design education practice in colleges and universities has been extended and expanded. Since art and design in colleges and universities is a comprehensive discipline based on the collaboration of art, humanities and science and technology, it requires practitioners to have innovative and complex qualities. Nowadays, artificial intelligence has been involved in many disciplines, and artificial intelligence itself has a lot in common with art and design, while the field of education is also undergoing a profound innovation under the influence of artificial intelligence. In view of this, this paper takes the teaching practice of art and design in colleges and universities under the background of artificial intelligence as the research topic and analyzes the deep impact of artificial intelligence on the teaching practice of art and design from the paradigm level. It not only breaks the historical and progressive research on teaching practice, but also provides a new research perspective for the development of teaching practice, and thus promotes the deep integration of AI technology and college art education practice. This study integrates literature research method and case study method to investigate the impact of AI on various elements of art and design teaching practice in colleges and universities, and whether this impact will reach the paradigm level. The paradigm of art and design teaching practice and its migration are studied and analyzed, and a paradigm migration model from multimedia teaching practice to information teaching practice and finally to intelligent teaching practice is constructed, and typical application cases under the guidance of intelligent art and design teaching practice paradigm are detailed. This initiative can provide new ideas and reference implications for future intelligent teaching practice.
How does the Guangdong-Macao Cooperation Zone innovate its administrative system to enhance policy implementation capacity—based on the perspective of cultural and creative industries policy
Authors: Zhang Quan
Published: February 2025

This study explores how the Hengqin Guangdong-Macao In-depth Cooperation Zone utilizes "One Country, Two Systems" to innovate administrative systems and optimize cultural and creative industries (CCI) policy implementation. Combining qualitative and quantitative methods, it aims to uncover the internal mechanisms and external drivers of CCI development in the Zone. Using Vosviewer, the latest global research on industrial policies and CCI was systematically analyzed. The study highlights that effective public policy intervention can amplify CCI's positive effects and promote industry prosperity. Qualitative analysis, including content analysis with Octopus Software and Rostcm6, focused on the Zone's collaboration with Macao in developing CCI with Zen aesthetics, revealing their unique contributions to Macao's industrial diversification. Field research explored how the Zone attracts and retains CCI talents through an institutionally inclusive environment, finding distinct preferences for public policies among different talent groups. Regarding administrative innovations, the Zone's Management and Executive Committee-centered system facilitates integration and coordinated development with Macao, reflecting the central and provincial governments' commitment to empowering the Zone. Results show that this unique administrative system enhances investment willingness and promotes CCI agglomeration, laying a foundation for CCI's sustained and healthy development. Overall, this research provides theoretical support and practical guidance for promoting local industrial policy implementation through administrative innovations in the Hengqin Guangdong-Macao In-depth Cooperation Zone.
Adaptive Customization of Electronic Commerce Packaging for Sustainable Business Development
Authors: Shenglin Liu  , Wan Gongchao
Published: February 2025

To address the growing demand for sustainable practices in e-commerce logistics, this research explores the innovative application of the NSGA-II algorithm for customized packaging optimization in distribution. A novel unconstraint mixed-integer linear programming mathematical model was developed and integrated with the NSGA-II algorithm to optimize packaging design dimensions and material properties. The approach emphasizes flexibility, compressibility, and adaptability to achieve an optimal balance between resource efficiency and product protection. Through rigorous simulation experiments, the NSGA-II algorithm demonstrated significant material savings while maintaining packaging integrity, achieving reductions of 1.87% in packaging quantity, 8.97% in volume, and 3.33% in weight. The results underscore the model’s alignment with e-commerce objectives of cost reduction and environmental impact minimization, offering a scalable framework for resource-efficient and sustainable distribution packaging solutions.
Bilateral Interaction between Mainland China and Hong Kong Audiovisual Products under the Perspective of Cross-cultural Communication
Authors: Zhou Zhengyi , Zheng Liuyi , Qi Yuxi
Published: February 2025

At the present time, the dissemination of media represents one of the most significant methods of facilitating communication between disparate locations. The dissemination of cultural and creative products expressed in audiovisual formats facilitates cross-regional communication, thereby reinforcing the common culture within the group. Hong Kong, China and Mainland China represent distinct regions of the Han Chinese Cultural Circle. They not only reflect the cultural attractions within this cultural circle through a variety of media communication, but also respond to external cultural influences in the context of globalization. The latest figures indicate that Mainland China represents the largest outlet for Hong Kong's audio-visual products. However, the dissemination effect of Mainland products in Hong Kong is generally less pronounced than that of products from the United States and Japan. In particular, the United States has utilized the brand name of Hollywood films to disseminate its culture and values on a global scale through cross-cultural communication. While the shared culture provides audiovisual products with a lasting communication advantage in both Hong Kong and the Mainland, it can also be used at a later stage to further promote in-depth cultural exchanges and dissemination between the two places through policies, cooperation and cultural adaptations. However, this approach also faces challenges, including the USA's cultural leadership within traditional cultural circles.
Silver Economy Industry Market Consumption Characteristics Research
Authors: Wu Wanlu , Ying Shi , Wu Yuting
Published: February 2025

This study focuses on the consumption characteristics of the silver economy industry market.The silver economy refers to the total economic activities generated by providing products and services to meet the special needs of the elderly. Due to the imbalance in global population development, this economic phenomenon has significant regional characteristics worldwide. This study focuses on the consumption characteristics of the silver economy industry market, revealing the uniqueness of the consumption behavior of this group and market potential through in-depth analysis of the silver economy. In the market analysis section, we conducted a detailed study on the market size and growth trends of the silver economy in terms of consumption, services, and products, finding that it is showing a rapid development trend. Especially as the demand of the elderly for industries such as health, entertainment, and information technology is gradually increasing, this phenomenon reflects the diversification of the silver market in industrial structure. Through an in-depth analysis of the competitive situation of the main participants, we found that many companies in the market are enhancing their competitiveness by innovating services and personalized products. In-depth research on consumption characteristics reveals that the elderly are increasingly tending to rational choice and brand loyalty in consumption decisions, and the attention to quality and safety has significantly increased, forming a unique consumption psychology. This paper also discusses the impact of the policy environment on the silver economy, proposing systematic policy support suggestions, including strengthening community elderly care services and promoting the application of smart technology, to provide support for the sustainable development of the silver economy. It is expected to provide theoretical references and practical guidance for policymakers and industry practitioners in related fields.
Efficiency of reverse genetics methods for rescuing severe acute respiratory syndrome coronavirus 2
Authors: Park Chang-Joo , Kim Taehun , Yoo Seung-Min , Lee Myung-Shin , Cho Nam-Hyuk , Park Changhoon
Published: February 2025

Bacteria-free reverse genetics techniques are crucial for the efficient generation of recombinant viruses, bypassing the need for labor-intensive bacterial cloning. These methods are particularly relevant for studying the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. This study compared the efficiency of three bacteria-free approaches—circular polymerase extension reaction (CPER) with and without nick sealing and infectious sub-genomic amplicons (ISA)—to bacterial artificial chromosome (BAC)-based technology for rescuing SARS-CoV-2. Significant differences in viral titers following transfection were observed between methods. CPER with nick sealing generated virus titers comparable to those of the BAC-based method and 10 times higher than those of the standard CPER. In contrast, ISA demonstrated extremely low efficiency, as cytopathic effects were detected only after two passages. All rescued viruses exhibited replication kinetics consistent with those of the original strain, with no significant deviation in replication capacity. Furthermore, the utility of CPER and ISA in genetically modifying SARS-CoV-2 was demonstrated by successfully inserting the gene encoding green fluorescent protein into the genome. Overall, this study underscores the potential of bacteria-free methods, such as CPER and ISA, in advancing SARS-CoV-2 research while highlighting their significant differences in efficiency.
Riittääkö fluoriton omahoito ehkäisemään kariesta?
Authors: Hólm Helmisdóttir Lára , Konradsson Katarina , Palotie Ulla , Twetman Svante , Young Alix
Published: February 2025

Ammattikäyttöön ja omahoitoon tarkoitetut fluoridit sisältyvät WHO:n välttämättömien lääkkeiden luetteloon. Hammaskarieksen ehkäisyn ja hallinnan kulmakivi on hampaiden harjaaminen fluorihammastahnalla kahdesti päivässä. Raskauden ja lapsuuden aikaisen liiallisen fluoridialtistuksen kielteiset terveysvaikutukset, kuten fluoroosi ja neurotoksisuus, herättävät kuitenkin huolta. Tämän vuoksi artikkelin tavoitteena oli tutkia fluorittoman omahoidon tehokkuutta. Kolmesta sähköisestä tietokannasta etsittiin systemaattisia katsauksia ja mukaan otettiin kuusi artikkelia, joista kolmessa oli pieni tai kohtalainen harhan riski. Systemaattiset katsaukset sisälsivät yhteensä 28 ensisijaista tutkimusta, joissa fluorihammastahnaa verrattiin plaseboon tai tilanteeseen ilman interventiota. Kaikki tutkimukset puolsivat fluorihammastahnan käyttöä hammaskarieksen ennaltaehkäisyssä. Näytönaste hammasvälien puhdistamisen hyödyistä hampaiden harjauksen lisänä karieksen ennaltaehkäisyssä oli heikko. Julkaistujen systemaattisten katsausten perusteella olemme vakuuttuneita siitä, että itse suoritettu hampaiden harjaus fluorihammastahnalla ehkäisee kariesta tehokkaammin kuin harjaus lumehammastahnalla tai harjaamatta jättäminen. Tästä huolimatta myös fluorittomilla vaihtoehdoilla voi olla kariesta ehkäisevää vaikutusta, ja suun terveydenhuollon ammattilaisten on oltava tietoisia fluorittomista vaihtoehdoista opastaakseen henkilöitä, jotka eivät halua käyttää fluoria sisältäviä tuotteita.
Exploring Internal Challenges in Internationalisation: A Case of a Software as a Service (SaaS) Internationaliser
Authors:   University of Tartu, Õim Karl Erik , Leis Tairi
Published: February 2025

Purpose: The article examines the internal challenges encountered in internationalisation, focusing on Software as a Service (SaaS) companies. It aims to contribute to the literature on SaaS companies’ internationalisation by examining the unique challenges they face and the challenges they share with other types of firms.

Design/methodology/approach: It encompasses a case study of an international Estonian SaaS company. It is based on a semi-structured, in-depth interview and various additional information sources: internal information, websites, and publicly available financial data.

Findings: When the company was young, it lacked the capacity to cope with competitors. Establishing itself as a stable and trustworthy partner for larger firms was also challenging. Its marketing capabilities were limited, and its competitiveness was low compared to the more established firms. Additional challenges included communication issues, customer disinterest, customer specificity (e.g., the tendency of customers to also become competitors), lack of trust, and insufficient references. Research limitations/implications: It is based on a single case study.

Originality/value: It enriched the literature by directing attention to the internationalisation challenges, explicitly focusing on SaaS companies. It aimed to understand how various internal challenges can affect their internationalisation. The area is understudied, and SaaS companies’ internationalisation needs more coverage in future research. This study contributes toward filling the research gap by offering valuable insights into the internal challenges of SaaS companies’ internationalisation. It provides suggestions to managers and those pursuing global expansion or already operating in international markets.
Navigation-guided orbital medial wall fracture reconstruction
Authors: Jeon Jae Hyung , Jeon Hong Bae , Kim Hyonsurk , Kang Dong Hee
Published: February 2025

Background: Orbital medial wall fractures, which are more common than inferior wall fractures, have traditionally been difficult to diagnose with conventional radiography. As the fracture extends deep into the bony orbit, accurately visualizing internal structures becomes challenging, increasing the risk of optic nerve compression. In a previous study, the author introduced a technique for treating medial orbital wall fractures using a combined transethmoidal and transcaruncular approach. In this study, the authors hypothesized that the use of surgical navigation could enhance precision, safety, and anatomical reconstruction in this approach and employed navigation during surgery for medial orbital wall fractures and evaluated whether it improved postoperative functional and anatomical outcomes while minimizing complications.Methods: From September 2021 to November 2023, 48 patients with isolated medial wall fractures underwent surgical treatment using a combined transcaruncular approach and transethmoidal packing to repair the orbital fracture. Of these patients, 23 underwent surgery with the use of intraoperative navigation, while the other 25 did not. Intraoperative navigation was employed to facilitate precise fracture reduction and reduce the risk of optic nerve injury. The outcomes were compared by dividing the patients into two groups. Preoperative and postoperative assessments included ophthalmologic evaluations, Hertel exophthalmometry, and computed tomography-based orbital volume measurements.Results: The surgical approach with intraoperative navigation was successfully performed in all patients. Postoperative outcomes showed full recovery without residual symptoms or complications. Orbital volume measurements indicated a significant reduction in the preoperative orbital volume ratio from 109.03% to 104.80% postoperatively (p< 0.001). However, changes in the Hertel scale were not statistically significant (p = 0.086).Conclusion: The integration of intraoperative navigation in medial orbital wall fracture surgery enhances the precision of medial orbital wall restoration and minimizes postoperative complications, supporting its use in the surgical management of medial orbital fractures.
The impact of geopolitical challenges on the development of the automotive market in the context of Industry 4.0
Authors: Chistyakov Ilya Aleksandrovich
Published: February 2025

The subject of the study is the mechanisms of influence of geopolitical challenges on the automotive market in the context of Industry 4.0. The object of the study is the transformational processes in the global and Russian automotive industries under the influence of sanctions, supply chain disruptions and digitalization trends. Special emphasis is placed on the processes of regionalization of the global economy, which is the result of a rethinking of globalization by world powers and the realization that the current global political environment is too unstable, which in turn pushes countries to strengthen their own economies and economic ties with new international partners. The aim of the study is to identify the key factors influencing political instability and new technological solutions on the development of the automotive industry in the context of the transition from globalization to regionalization. Special attention is paid to the Russian automotive market, its current state and prospects. It is also noted how increasing the technological stability of an enterprise will make it less susceptible to political risks.   The paper uses analytical methods, including comparative analysis, economic modeling, and a review of current scientific sources and statistical data. The scientific novelty lies in an integrated analysis of the impact of geopolitical challenges on the automotive market through the prism of Industry 4.0 technologies. The main results include conclusions on the need to develop Industry 4.0 technologies to strengthen the national automotive industry and achieve technological sovereignty, recommendations for creating sustainable regional economic platforms for technological exchange with friendly countries, conclusions on the importance of government support programs that They include tax incentives and subsidies to stimulate the domestic automotive industry and specifically high-tech solutions in it, as well as a strategy of cooperation with Chinese automakers with a focus on localization and technology exchange to increase the competitiveness of the Russian automotive industry. The presented results help to form a more sustainable model for the development of the automotive industry, able to withstand external challenges.
Nationalization, Expropriation, and Confiscationфы as the Grounds for Termination of Property Rights by the Will of the State: A Comparative Analysis
Authors: Kutovoi Nikita Sergeevich
Published: February 2025

The article is devoted to the legal analysis of mechanisms for the forced termination of property rights at the initiative of the state, including nationalization, expropriation, and confiscation. In modern conditions, especially in light of geopolitical changes, seizure of private and corporate property has gained particular significance. The study examines the theoretical foundations of these legal institutions, their regulatory framework in Russian legislation, and their compliance with international standards. Special attention is given to the practice of nationalizing the property of foreign companies and individuals, particularly in the context of economic sanctions and political decisions. Author analyzes existing gaps in legislation, such as the lack of clear definitions of expropriation and procedural mechanisms for nationalization. Various regulatory models in foreign countries, including the United States, European Union states, Venezuela, and Germany, are explored. The legal consequences of forced property seizure and possible directions for improving Russian legislation to enhance its predictability and protect property owners' interests are also considered. The study employs a comparative legal method to identify key differences between nationalization, expropriation, and confiscation. Historical, formal-legal, and doctrinal research methods are also used. The article's scientific novelty lies in the systematization of concepts, identification of legal characteristics and distinctions among these institutions. The author argues for the necessity of defining expropriation in Russian law and developing a special nationalization law to ensure procedural clarity and property rights protection. The study demonstrates that nationalization is recognized in international practice as a legitimate state policy tool, provided fair compensation is ensured. The analysis of foreign experience, particularly in the U.S. and EU countries, confirms the importance of a legislatively established compensation mechanism for forced property seizure. Based on the research findings, recommendations are proposed to improve Russian legislation, eliminate legal uncertainty, and establish balanced regulation of these institutions.
História da raiva no Brasil
Authors: Almeida Marilene Fernandes de , Queiroz Luzia Helena
Published: February 2025

A raiva é um capítulo fascinante na história da ciência e da medicina e é uma doença que acompanha a humanidade desde a Antiguidade. Neste livro, as autoras relatam a história da raiva no Brasil e, durante esse estudo, muitas dúvidas surgiram e as guiaram durante a pesquisa. Os indígenas brasileiros já conheciam a raiva? Como essa doença era vista e tratada nessas culturas? Qual a importância dessa infecção e como era tratada no período colonial e imperial brasileiro? Quais animais estavam envolvidos no ciclo epidemiológico? Os morcegos já eram reservatórios do vírus da raiva quando os europeus chegaram ao Brasil ou a doença foi introduzida pela colonização? Algumas respostas a essas questões foram obtidas em relatos de naturalistas durante viagens por terras brasileiras, revistas médicas, jornais, leis e outras publicações da época em que a doença ainda era chamada de hidrofobia. Nesta obra também são reproduzidas as descrições de receitas milagrosas e os procedimentos curiosos que prometiam a cura da infecção. Este livro dedica especial atenção à história dos Institutos Pasteur no Brasil, das instituições de pesquisa e executoras das medidas de controle da raiva país. Além disso, apresenta a ocorrência e a evolução do conhecimento sobre a doença no mundo e no Brasil ao longo dos séculos e descreve sua situação atual.
Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells
Authors: Tsutsumi Hiroki , Chiba Tomoki , Fujii Yuta , Matsushima Takahide , Kimura Tsuyoshi , Kanai Akinori , Kishida Akio , Suzuki Yutaka , Asahara Hiroshi
Published: February 2025

Tendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging. We investigated the characteristics of tendon stem/progenitor cells (TSPCs) by focusing on the declining tendon repair capacity with growth. Using single-cell RNA sequencing on Achilles tendon cells from 2- and 6-week-old mice, we identified
Cd55
and
Cd248
as novel surface antigen markers for TSPCs. Combining single-nucleus ATAC and RNA sequencing analyses revealed that
Cd55
and
Cd248
positive fractions in tendon tissue are TSPCs, with this population decreasing at 1 weeks. We also identified candidate upstream transcription factors regulating these fractions. Functional analyses of isolated CD55/CD248 positive cells demonstrated high clonogenic potential and tendon differentiation capacity, forming functional tendon-like tissue
in vitro
. This study establishes CD55 and CD248 as novel TSPC surface antigens, potentially advancing tendon regenerative medicine and contributing to the development of new treatment strategies for tendon and ligament injuries.
The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth
Authors: Fuentes Valenzuela Lucas , Francois Paul , Skotheim Jan
Published: February 2025

Genetic analyses, which examine the phenotypic effects of mutations both individually and in combination, have been fundamental to our understanding of cellular functions. Such analyses rely on a neutrality function that predicts the expected phenotype for double mutants based on the phenotypes of the two individual non-interacting mutations. In this study, we examine fitness, the most fundamental cellular phenotype, through an analysis of the extensive colony growth rate data for budding yeast. Our results confirm that the Product neutrality function describes the colony growth rate, or fitness, of a double mutant as the product of the fitnesses of the individual single mutants. This Product neutrality function performs better than additive or minimum neutrality functions, supporting its continued use in genetic interaction studies. Furthermore, we explore the mechanistic origins of this neutrality function by analyzing two theoretical models of cell growth. We perform a computational genetic analysis to show that in both models the product neutrality function naturally emerges due to the interdependence of cellular processes that maximize growth rates. Thus, our findings provide mechanistic insight into how the Product neutrality function arises and affirm its utility in predicting genetic interactions affecting cell growth and proliferation.
Transcriptional complexity in the insect central complex: single nuclei RNA-sequencing of adult brain neurons derived from type 2 neuroblasts
Authors: Epiney Derek , Morales Chaya Gonzalo N , Dillon Noah R , Lai Sen-Lin , Doe Chris Q
Published: February 2025

In both invertebrates such as
Drosophila
and vertebrates such as mouse or human, the brain contains the most diverse population of cell types of any tissue. It is generally accepted that transcriptional diversity is an early step in generating neuronal and glial diversity, followed by the establishment of a unique gene expression profile that determines morphology, connectivity, and function. In
Drosophila
, there are two types of neural stem cells, called Type 1 (T1) and Type 2 (T2) neuroblasts. In contrast to T1 neuroblasts, T2 neuroblasts generate intermediate neural progenitors (INPs) that expand the number and diversity of cell types. The diversity of T2-derived neurons contributes a large portion of the central complex (CX), a conserved brain region that plays a role in sensorimotor integration. Recent work has revealed much of the connectome of the CX, but how this connectome is assembled remains unclear. Mapping the transcriptional diversity of neurons derived from T2 neuroblasts is a necessary step in linking transcriptional profile to the assembly of the adult brain. Here we perform single nuclei RNA sequencing of T2 neuroblast-derived adult neurons and glia. We identify clusters containing all known classes of glia, clusters that are male/female enriched, and 161 neuron-specific clusters. We map neurotransmitter and neuropeptide expression and identify unique transcription factor combinatorial codes for each cluster (presumptive neuron subtype). This is a necessary step that directs functional studies to determine whether each transcription factor combinatorial code specifies a distinct neuron type within the CX. We map several columnar neuron subtypes to distinct clusters and identify two neuronal classes (NPF+ and AstA+) that both map to two closely related clusters. Our data support the hypothesis that each transcriptional cluster represents one or a few closely related neuron subtypes.
Airport accessibility for neurodivergent passengers
Authors: Castro Rafael Teixeira de , Batista Mariana Miranda , Andrada Maria Eduarda Santos
Published: February 2025

This study examines the relationship between neurodivergence, tourism, air transportation, and social inclusion, with a particular focus on airport accessibility. Employing a bibliographic review and an exploratory qualitative-quantitative research methodology, the study investigates how airports are adapting to meet the needs of neurodivergent passengers. The primary aim is to analyze the strategies implemented by airports worldwide to enhance accessibility for individuals with various neurodivergences. To achieve this objective, a survey and subsequent analysis of accessibility practices targeting neurodivergent individuals were conducted across selected airports globally. The airports included in this research were chosen based on the criterion of officially adopting the sunflower lanyard as an accessibility measure. The findings reveal that while accessibility initiatives are present in airports of varying sizes, governance models, and locations, major airports often prioritize simpler, low-cost measures over more comprehensive structural adaptations. The study concludes by emphasizing the need for further research and the development of more inclusive strategies.
Alloplastic Reconstruction in Post-ablation Oral Squamous Cell Carcinoma Surgery: A Case Report
Authors: Gurav Tikeshwari Kailas , Pawar Shreeya , Gupta Chetan , Bhola Nitin , Jadhav Vikrant
Published: February 2025

Surgical management of Oral Squamous Cell Carcinoma (OSCC) leads to ablative defects. There are various reconstructive options for these defects, such as autogenous grafts from the patient, including local flaps, regional flaps and distant flaps. Harvesting these flaps to reconstruct the defects can cause a significant amount of morbidity. The use of alloplasts in the reconstruction of the head and neck can reduce this morbidity at the donor site and decrease the surgical time required for flap harvesting. The present case of a 45-year-old female patient presented a microinvasive squamous cell carcinoma in whom an alloplast was used to restore the ablative defect following excision. This case report demonstrates the innovative application of alloplastic materials in surgery, eliminating the need for harvesting autologous grafts and minimising pain, recovery time and complications for patients postsurgery. This method reduces operating time, enhances patient outcomes and is flexible enough to meet various clinical requirements. The present case study highlights the challenges of restoring shape and function while considering aesthetic concerns by examining a cutting-edge alloplastic reconstruction procedure used in a patient following OSCC ablation. The surgical technique, materials utilised and results obtained after surgery are described herein, illustrating how alloplastic techniques can successfully overcome the drawbacks of conventional reconstructive methods. The results suggest that, in the context of OSCC, alloplastic reconstruction can improve surgical outcomes and enhance the patient’s quality of life with proper planning and implementation. This instance emphasises the importance of customised treatment programs and the potential of advanced reconstructive methods to address the specific challenges posed by oral cavity abnormalities.