bluuebunny/crossref_metadata_2025 huggingface dataset:
Text Network Analysis of Research Topics and Trends on Simulations Using Virtual Patients in Nursing Education
Authors: Song Miok , Moon Jeong Eun , Jang Aeri
Published: January 2023

Simulations using virtual patients have been utilized as an effective method in nursing education. However, keyword network analyses and topic modeling on simulations using virtual patients in nursing education have not yet been performed. In this study, 213 articles were retrieved from online research article databases. Abstracts from these articles were extracted, and network analysis was conducted using NetMiner version 4.3 (Cyram Inc, Seongnam, South Korea). Based on the study's analysis, scenario, communication, system, assessment, person, disaster, and management were identified as the keywords with high centrality values. Therefore, they were determined to be influential in the network. After topic modeling, 10 topics were derived as dementia care competency, pain assessment, airway placement management, operating procedure, presence and satisfaction, communication and attitude improvement, platform world, disaster response, game and video usability, and system for confidence. The identified trends in this study will help grasp the trends and insight to guide future research directions on simulations using virtual patients in nursing education.
2021 Survey of Keratoplasty Postoperative Steroid Management
Authors: Boychev Nikolay , De Arrigunaga Sofia , Zhao Yan , Ciolino Joseph B.
Published: January 2023

Purpose:

The aim of the study is to investigate US-based ophthalmologists’ preferred corneal transplant techniques and postoperative steroid regimen.

Methods:

Ophthalmologists attending the 2021 Cornea and Eye Banking Forum and/or Cornea Subspecialty Day were surveyed in person.

Results:

Ninety-two ophthalmologists with a median of 13 years (range of 1–35; mean of 14.5; ±9.05 mean ± SD) of experience as attending clinicians were surveyed. One hundred percent of the surgeons performed penetrating keratoplasty, which was followed by 96.7% for Descemet stripping endothelial keratoplasty, 90.2% for Descemet membrane endothelial keratoplasty, and 72.8% for deep anterior lamellar keratoplasty. Prednisolone 1% for postoperative care was the preferred choice across all surveyed keratoplasty techniques and postsurgery time intervals. All surgeons reported steroid administration frequency of 4 times a day in the first month and once a day after 12 months postkeratoplasty. To manage ocular hypertension after corneal transplantation, the leading approach was adding a glaucoma medication (44.6%), and beta-adrenergic antagonists were ranked as the most preferred choice by 59 (66.3%) of the respondents. For graft rejection after corneal transplantation, topical steroids (79.8%) were the initial treatment of choice with hourly administration being the most common frequency prescribed (87.4%). Most surgeons either agreed or strongly agreed (78.4%) that a randomized clinical trial evaluating the safety and efficacy of different steroid regimens after corneal transplantation would influence their clinical decision making.

Conclusions:

Prednisolone remains the predominantly used steroid across different keratoplasties. Steroid regimens are similar for non–high-risk penetrating keratoplasty, Descemet membrane endothelial keratoplasty, Descemet stripping endothelial keratoplasty, and deep anterior lamellar keratoplasty. To treat graft rejection, surgeons tend to initially add a glaucoma medication than to reduce the potency or frequency of the steroid.
Clinical thresholds in pain-related facial activity linked to differences in cortical network activation in neonates
Authors: Bucsea Oana , Rupawala Mohammed , Shiff Ilana , Wang Xiaogang , Meek Judith , Fitzgerald Maria , Fabrizi Lorenzo , Pillai Riddell Rebecca , Jones Laura
Published: January 2023

In neonates, a noxious stimulus elicits pain-related facial expression changes and distinct brain activity as measured by electroencephalography, but past research has revealed an inconsistent relationship between these responses. Facial activity is the most commonly used index of neonatal pain in clinical settings, with clinical thresholds determining if analgesia should be provided; however, we do not know if these thresholds are associated with differences in how the neonatal brain processes a noxious stimulus. The objective of this study was to examine whether subclinical vs clinically significant levels of pain-related facial activity are related to differences in the pattern of nociceptive brain activity in preterm and term neonates. We recorded whole-head electroencephalography and video in 78 neonates (0-14 days postnatal age) after a clinically required heel lance. Using an optimal constellation of Neonatal Facial Coding System actions (brow bulge, eye squeeze, and nasolabial furrow), we compared the serial network engagement (microstates) between neonates with and without clinically significant pain behaviour. Results revealed a sequence of nociceptive cortical network activation that was independent of pain-related behavior; however, a separate but interleaved sequence of early activity was related to the magnitude of the immediate behavioural response. Importantly, the degree of pain-related behavior is related to how the brain processes a stimulus and not simply the degree of cortical activation. This suggests that neonates who exhibit clinically significant pain behaviours process the stimulus differently and that neonatal pain-related behaviours reflect just a portion of the overall cortical pain response.
Development and Evaluation of a Web-Based Application for Trauma Nursing Documentation in Thailand: A Feasibility Study
Authors: Pearkao Chatkhane , Impool Tawatchai , Tantibundit Porntipa , Hongveang Somporn , Potisopha Wiphawadee , Sampaothong Tanakorn
Published: January 2023

Background:

Electronic nursing documentation has advantages for monitoring and improving the quality of trauma nursing documentation. However, electronic nursing documentation has rarely been implemented in Thailand.

Objectives:

This study aimed to assess the feasibility and nursing satisfaction of a web-based trauma nursing documentation application.

Methods:

A descriptive cross-sectional survey design was used to assess the feasibility and nursing satisfaction with a web-based trauma nursing documentation application. The application was based on literature review, Advanced Trauma Life Support principles, and the North American Nursing Diagnosis Association. The survey was administered to trauma and emergency department registered nurses in a hospital in Thailand from November 2021 to January 2022. Patient data were also extracted from the web application system for analysis.

Results:

A total of 59 nurses piloted the web-based application on 79 trauma patients. Of 59 nurses, 45 (76.3%) were female, 44 (74.6%) had worked in the emergency department for more than 5 years, and 49 (83.1%) had no prior experience with using web-based applications. The nurses were satisfied with the application (M = 3.51, SD = 0.62), and they suggested that it was feasible to apply in practice (M = 3.46, SD = 0.79).

Conclusion:

These preliminary data demonstrate that implementing a web-based application for trauma nursing documentation in the emergency department is feasible and satisfactory to nurses.
Pain management of newly diagnosed sarcoma patients at a single center
Authors: Yang Peiyi , Su Yan , Zhao Wen , Duan Chao , Li Ying , Zhou Yuchen , Wang Li , Cai Siyu , Zhou Xuan , Ni Xin , Ma Xiaoli
Published: January 2023

Background:

Systematic pain management of children is insufficient in China, and there is no literature on pain in children with sarcoma.

Methods:

Clinical data of 188 patients with newly diagnosed sarcoma admitted to the Medical Oncology Department of Beijing Children’s Hospital was collected from October 2018 to December 2020. Children experiencing pain received analgesic treatment and regular assessment.

Results:

Thirty-seven patients (19.7%) suffered from pain. Six cases (16.2%) had mild pain, 17 (46.0%) moderate, and 14 (37.8%) severe. Daily lives of 31 patients were affected by pain. Twenty-six cases had bone invasion. The analgesic rate was 54.1% before admission and 89.2% after admission. Nine cases were treated with oral morphine regularly, and their pain was relieved before chemotherapy; the dose of morphine was 0.14 ± 0.034 mg/kgQ4H when the target was reached. No serious adverse reactions were observed. The period of morphine application after chemotherapy was 5 to 9 days, and there was no withdrawal reaction.

Conclusion:

Pain in children with newly diagnosed sarcoma was mainly moderate to severe, and the incidence of pain in sarcoma with bone invasion was higher, with greater intensity. Patients who received standardized pain assessment and regular analgesics reached pain relief quickly, and no serious adverse reactions were observed within the recommended dosage.
Effects of Shenxiang Suhe Pill on coronary heart disease complicated with nonalcoholic fatty liver disease: A case–control study
Authors: Ni Jie , Chen Chen , Tang Jiake , Hu Siqi , You Yao , Zhang Shenghui , Jiang Jingjie , Wang Chunyi , Wen Wen , Zhang Xingwei , Wang Mingwei
Published: January 2023

Objective:

To observe the clinical effect of Shenxiang Suhe Pill in the treatment of coronary heart disease (CHD) patients with nonalcoholic fatty liver disease (NAFLD).

Methods:

56 CHD patients with NAFLD were randomly divided into an experimental group and control group. The control group was treated by conventional western medicines, while the experimental group was given Shenxiang Suhe Pill in addition to the treatment of the control group. Both groups were treated for 12 weeks. Before treatment and after 12 weeks of treatment, the clinical efficacy indices of the 2 groups were evaluated, including transient elastic B-ultrasound (Fibroscan), controlled attenuation parameter (CAP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride (TG), total cholesterol, high sensitivity-reactive protein (hs-CRP) and lactate dehydrogenase (LDH).

Results:

Compared with the control group, the CAP value of the experimental group decreased more significantly, and the severity classification of NAFLD was also significantly improved (P < .05). LDH and hs-CRP in the experimental group decreased after treatment (P < .05). TG and high density lipoprotein cholesterol indicators improved more in the experimental group than in the control group (P < .05). ALT and AST in neither group showed significant change (P > .05).

Conclusion:

Shenxiang Suhe Pills has a significant overall curative effect in the treatment of patients with CHD complicated with NAFLD. It can reduce liver lipid deposition, reduce the severity of NAFLD, and has lipid-lowering and anti -inflammatory effects.
Pathomechanisms of SARS-CoV-2 infection and development of atherosclerosis in patients with COVID-19: A review
Authors: Gospodarczyk Alicja Zofia , Wojciechowska Celina , Marczewski Kamil Piotr , Gospodarczyk Natalia Justyna , Zalejska-Fiolka Jolanta
Published: January 2023

The pandemic of coronavirus disease 2019 (COVID-19) has posed a major health challenge for over 2 years. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes it belongs to single-stranded ribonucleic acid viruses and causes acute respiratory distress syndrome. The initial outbreak was discovered in December 2019 in Wuhan province, where SARS-CoV-2 quickly spread to other countries. In addition to respiratory disorders, it has been shown that during and after COVID-19 infection, cardiovascular diseases are often developed or exacerbated, such as: arterial hypertension, coronary artery disease, arrhythmias, heart failure and thromboembolic complications. In view of the higher prevalence of atherosclerosis in patients with COVID-19, we described the pathomechanisms of the development of this infection and the possible correlations between SARS-CoV-2 infection and thromboembolic complications. We focused on the role of the inflammatory response, renin-angiotensin system and endothelial dysfunction in the development of atherosclerosis in patients with COVID-19. A thorough understanding of the hemodynamic mechanisms and the impact of the infection on the cardiovascular system will allow for the proper selection of appropriate therapy in patients after SARS-CoV-2 infection.
Home-based cardiac rehabilitation: A review of bibliometric studies and visual analysis of CiteSpace (2012–2021)
Authors: Liu Jingyu , Wang Lingyu , Fang Haiyan , Wang Xiang , Wu Lingsha , Zhang Jing
Published: January 2023

Home-based cardiac rehabilitation has been a major area in cardiac rehabilitation research for a long time. However, there are few systematic studies in this field using bibliometric analysis. We collected articles and reviews for home-based cardiac rehabilitation from the Web of Science Core Collection. Our objectives were to perform a bibliometric analysis and visualization study to determine hotspots and trends of home-based cardiac rehabilitation, identify collaboration and influence among authors, countries, institutions, and journals, and assess the knowledge base to develop clinical research in the future. This study will provide a valuable reference for researchers concerned with HBCR.
The risk factors of the occurrence of inguinal hernia in ESRD patients receiving dialysis treatment: An observational study using national health insurance research database
Authors: Chiu Pin-Han , Liu Jui-Ming , Hsieh Ming-Li , Kao Wei-Tang , Yu Kai-Jie , Pang See-Tong , Lin Po-Hung
Published: January 2023

With the quickly growing population of patients receiving dialysis treatment in Taiwan in recent years, concerns about whether more incidence of inguinal hernia exists in dialysis patients are increasing. In Taiwan, peritoneal dialysis (PD) and hemodialysis (HD) are the 2 most common dialysis types. Therefore, the relationship between dialysis type and inguinal hernia occurrence needs to be evaluated and compared. Our retrospective cohort study included a study population total of 3891 patients diagnosed with end stage renal disease (ESRD) under the HD or PD procedure from 2001 to 2009 from the Longitudinal Health Insurance Database. Also, International Statistical Classification of Diseases and Related Health Problems 9th Revision codes were used to identify ESRD and hernia occurrence. Cox proportional-hazards regression model was applied to measure the risk factors to the hernia occurrence. During the follow-up periods of 3 years, the number of hernia occurrences was 44 (1.13%), 1 (0.03%), and 8 (0.21%) with inguinal, femoral, and ventral hernias, respectively. Only the dialysis type revealed significantly increased hernia risk because PD would increase hernia risk 7 times (adjusted hazard ratio [aHR] = 6.98, 95% CI = 3.59–13.25) than HD. If the patients received PD and shifted to HD later, the risk of hernia was 5 times (aHR = 4.98, 95% CI = 2.29–10.85) than patients with HD. Patients with ESRD receiving PD or PD-HD shift were risk factors of inguinal hernia occurrence. The results may help clinicians increase the alert of possible risk factors and complications at the beginning of dialysis treatment in patients with ESRD.
ST-segment depression in atrioventricular nodal reentrant tachycardia: Important finding or just an artifact?
Authors: Mercik Jakub , Radziejewska Jadwiga , Pach Katarzyna , Zawadzki Grzegorz , Zyśko Dorota , Gajek Jacek
Published: January 2023

Background:

The ST segment is component of the QRS-T complex located between the QRS and the T wave. ST segment changes during tachycardia with narrow QRS mainly takes the form of ST segment depression. This phenomenon is often observed in young healthy people for whom an ischemic background is unlikely.

Materials and methods:

The study included 104 patients (71 women and 33 men) with paroxysmal narrow QRS complex tachycardia. In all patients electrophysiological study was performed and the diagnosis of atrioventricular nodal reentrant tachycardia was established. The arrhythmogenic substrate was then eliminated successfully by subsequent ablation using radiofrequency energy which confirmed the diagnosis, all patients had measured QRS components – QR, RS and RJ during the tachycardia and during the sinusrhythm. All of the measurements were done in lead V5.

Results:

The difference RJ-QR during tachycardia and sinus rhythm correlated negatively with tachycardia cycle length (R = 0.356, P = .001), first slowly, then rapidly reaching the cycle value of about 300 ms, then it decreases, stabilizing at the cycle level of about 270. By separating the RJ-QR in tachycardia and in the sinus rhythm from the tachycardia cycle, we can see that the correlation described in this point is largely due to the correlation between the heart rate and RJ-QR length in tachycardia.

Conclusions:

In patients with atrioventricular nodal reentrant tachycardia, there is a significant ST-segment depression during tachycardia episodes and the degree of this change is related to tachycardia cycle length. The most probable explanation of the ST-segment depression is the overlap of the QRS complex on the preceded T wave. This phenomenon is also influenced by some intrinsic properties of the individual electrocardiogram. It is possible to rule out ischemic origin of the presented ST segment change.
Lens subluxation after use of a percussion massage gun: A case report
Authors: Mu Jiancheng , Fan Wei
Published: January 2023

Rationale:

To report the first case of lens dislocation and secondary acute angle-closure glaucoma (AACG) following use of a percussion massage gun (PMG) around the eye.

Patient concerns:

A 69-year-old Chinese man had been using a PMG around his right eye for 2 months in order to relieve headache. After eye pain and blurred vision for 5 days, he went to the ophthalmological emergency department. His best-corrected visual acuity at distance was counting fingers.

Diagnosis:

The patient was diagnosed with lens subluxation, secondary AACG and pterygium in the right eye. Cataracts were diagnosed in both eyes.

Interventions:

The patient underwent phacoemulsification and anterior vitrectomy. After surgery, the patient was given eye drops containing tobramycin, dexamethasone, 0.1% bromfenac sodium hydrate ophthalmic solution and Mydrin-P for 1 month.

Outcomes:

At 3-month follow-up, uncorrected visual acuity in the right eye was counting fingers. The outcome of optometry in the right eye was +11.50 DS/−0.50 DC * 110°, with corrected-distance visual acuity of 4/20. IOP was 20.7 mm Hg in the right eye and 15.7 mm Hg in the left. Endothelium in the right cornea showed endothelial damage. Nevertheless, the patient reported no right eye pain anymore, and he indicated that he was satisfied with his situation.

Lessons:

Caregivers, sports professionals and the general public should be aware of the dangers of PMGs and the need to use them appropriately and safely, for example during self-massage and rehabilitation therapy. In particular, we recommend not using PMGs above the neck, which should be clearly indicated in instruction manuals.
A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review
Authors: Di Huang , Zhao Jiting , Zhu Xue , Zhou Xinpeng , Hu Yuanlong , Wang Mengjie , Qiu Zhanjun , Zhang Wei , Chen Xianhai
Published: January 2023

Lung adenocarcinoma (LUAD) is a highly heterogeneous disease with complex pathogenesis, high mortality, and poor prognosis. Cuproptosis is a new type of programmed cell death triggered by copper accumulation that may play an important role in cancer. LncRNAs are becoming valuable prognostic factors in cancer patients. The effect of cuproptosis-related lncRNAs (CRlncRNAs) on LUAD has not been clarified. Based on the Cancer Genome Atlas database, CRlncRNAs were screened by co-expression analysis of cuproptosis- related genes and lncRNAs. Using CRlncRNAs, Cox and LASSO regression analyses constructed a risk prognostic model. The predictive efficacy of the model was assessed and validated using survival analysis, receiver operating characteristic curve, univariate and multifactor Cox regression analysis, and principal component analysis. A nomogram was constructed and calibration curves were applied to enhance the predictive efficacy of the model. Tumor Mutational Burden analysis and chemotherapeutic drug sensitivity prediction were performed to assess the clinical feasibility of the risk model. The novel prognostic signature consisted of 5 potentially high-risk CRlncRNAs, MAP3K20-AS1, CRIM1-DT, AC006213.3, AC008035.1, and NR2F2-AS1, and 5 potentially protective CRlncRNAs, AC090948.1, AL356481.1, AC011477.2, AL031600.2, and AC026355.2, which had accurate and robust predictive power for LUAD patients. Collectively, the novel prognostic signature constructed based on CRlncRNAs can effectively assess and predict the prognosis of patients and provide a new perspective for the diagnosis and treatment of LUAD.
Massive hemorrhage arising of inferior thyroid artery by radiofrequency ablation for secondary hyperparathyroidism: Two case reports
Authors: Liu Xiaoling , Qin Xiachuan , Hu Xiaomin , Wang Zhihua
Published: January 2023

Patient concerns and diagnosis:

Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease. Radiofrequency ablation (RFA) is a safe and minimally invasive treatment for SHPT, which can effectively reduce the level of parathyroid hormone (PTH). Inferior thyroid artery (ITA) is a rare and dangerous complication, We report two cases of ITA bleeding caused by RFA. Intraoperative contrast-enhanced ultrasound (CEUS) can accurately show the source and scope of bleeding. Ultrasound guided RFA and compression hemostasis were successful.

Interventions:

During the operation, CEUS was used to detect ITA bleeding, bleeding range and location quickly and accurately at the early stage, and ultrasound guided compression and RFA were used to treat small bleeding points. ITA bleeding was timely and effectively controlled, and the bleeding range was limited to pseudoaneurysm.

Outcomes:

The patient received antiplatelet and anticoagulant therapy for 2 days, and the pseudoaneurysm was filled with thrombus 36 hours and 72 hours after surgery. Later, the ultrasonography examination showed that the hematoma was gradually absorbed and contracted.

Conclusion:

Although RFA is a safe and minimally invasive treatment for secondary hyperparathyroidism, rupture and bleeding of the ITA are rare and dangerous. CEUS can quickly and accurately judge bleeding, bleeding range and location in the early stage. Ultrasound guided compression and RFA of small ITA bleeding points can timely and effectively control bleeding, limit the bleeding range to pseudoaneurysms, and close themselves.
Predictors of sugar-sweetened carbonated beverage consumption and its effect on adiposity parameters of female Saudi students
Authors: Azzeh Firas S. , Hamouh Abrar E.
Published: January 2023

The prevalence of obesity has recently increased, accompanied by a steep increase in the consumption of sugar-sweetened carbonated beverages (SSCBs). This cross-sectional study was conducted to evaluate the impact of SSCB consumption on adiposity parameters and to identify factors associated with increased SSCB intake among young adult females in Makkah, Saudi Arabia. A validated closed questionnaire including 2 sections, general socioeconomic and behavioral characteristics and anthropometric measurements, was used for data collection of female students (n = 1616) from Umm Al-Qura University, Makkah, Saudi Arabia. Furthermore, height, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), and body composition were measured using an Omron HBF-510 body composition analyzer. Overall, 30.2% of the study participants consumed soda regularly. However, the percentages of occasional and never/rare soda intake were 40.1% and 29.7%, respectively. The results showed that BMI, WC, HC, body fat, and visceral fat increased with increasing SSCB intake. Physical inactivity, low income, smoking, low daily water intake, and obesity were associated with increased consumption of SSCB. In conclusion, a high rate of SSCB consumption increased obesity and body fat content in young adult females in Makkah City. Physical inactivity, low income, smoking, low daily water intake, and obesity were identified as predictors of increased SSCB consumption. Specific health education programs and effective public awareness campaigns could be held to address unhealthy SSCB drinking patterns to help improve young women’s health.
Eczema compound patents’ herbal combination rules research based on complex system entropy clustering: A review
Authors: Yang Xujie , Pei Xiaohua
Published: January 2023

The aim of this study is to investigate the herbal compound patents’ combination rules of eczema. Eczema herbal compound patents (oral drugs) from the past 29 years were collected, and a database was created. Complex system entropy clustering was used to analyze the prescription rule for eczema herbal compound patents. In total, 1039 eczema herbal compound patents, including 398 Chinese herbs, were identified. Complex system entropy clustering acquired high-frequency herbs, herbal couples, and core associations. Eczema herbal compound patents are known for clearing dampness and heat, dispelling poison, evacuating wind, and invigorating and cooling blood. By using complex system entropy clustering, herbal correlation of eczema herbal compound patents can be effectively analyzed.
Refractory adult-onset Still’s disease complicated with monoclonal gammopathy of undetermined significance: A case report
Authors: Saito Kenji , Asano Tomoyuki , Matsumoto Haruki , Fujita Yuya , Matsuoka Naoki , Ohkawara Hiroshi , Sumichika Yuya , Yoshida Shuhei , Temmoku Jumpei , Yashiro-Furuya Makiko , Sato Shuzo , Watanabe Hiroshi , Migita Kiyoshi
Published: January 2023

Rationale:

Adult-onset Still’s disease (AOSD) is a rare inflammatory disease characterized by a classic triad of daily spike fever, arthritis, and a typical salmon-pink rash. The involvement of inflammatory cytokines by various factors such as infection, drug, or neoplasm causes refractory AOSD.

Patient concerns:

We report a 63-year-old man with a high fever, rash, hyperferritinemia, and M proteinemia. His serum levels of interleukin-6 and interleukin-18 were remarkably high at 192 and 114,250 pg/mL, respectively.

Diagnosis:

AOSD complicated with monoclonal gammopathy of undetermined significance was diagnosed.

Interventions:

After steroid pulse therapy followed by oral prednisolone, cyclosporin, methotrexate, and colchicine, serum ferritin levels temporarily declined, but secondary cytomegalovirus infections exacerbated AOSD’s activity.

Outcomes:

Finally, after tocilizumab induction, AOSD activity was gradually suppressed over a long period.

Lessons:

The disease activity of AOSD is exacerbated by multiple factors, including comorbidities or infections. Clinicians need to consider that monoclonal gammopathy of undetermined significance complications might become AOSD refractory by an elevation of the inflammatory cytokines. Moreover, further prospective studies are required to confirm this result.
Review of systemic and syndromic complications of cannabis use: A review
Authors: Shah Jay , Fermo Olga
Published: January 2023

Purpose of review: Prescribed and non-prescribed cannabis use is common. Providers in specialties treating chronic pain – primary care, pain management, and neurology–will be coming across medical cannabis as a treatment for chronic pain, regardless of whether they are prescribers. It is important to be aware of the systemic and syndromic complications of acute and chronic cannabis use in the differential diagnosis of cardiac, cardiovascular, cerebrovascular, gastrointestinal, and psychiatric disorders.

Recent Findings: Medical cannabis is legal in 36 states. Studies have shown several potentially serious adverse effects associated with cannabis use.

Summary: Cannabis use has the potential to cause several complications that can be easily overlooked without a preexisting high index of suspicion.
Long-term prognosis after endoscopic resection of T1a-MM/T1b-SM1 esophageal squamous cell carcinoma
Authors: Ohki Daisuke , Tsuji Yosuke , Shinozaki Tomohiro , Sakaguchi Yoshiki , Mizutani Hiroya , Nagao Sayaka , Miura Yuko , Fukagawa Kazushi , Tamura Naoki , Yakabi Seiichi , Yamamichi Nobutake , Fujishiro Mitsuhiro
Published: January 2023

The objective of this study was to evaluate the long-term prognosis of T1a-MM/T1b-SM 1 esophageal squamous cell carcinoma (ESCC) after endoscopic resection (ER) and to validate the follow-up policy for pT1a-MM lymphovascular invasion (LVI)-negative ESCC. In this retrospective single-center analysis, patients who underwent ER for superficial ESCC between April 2002 and June 2021 were identified. The overall survival (OS), metastatic recurrence, and recurrence-free survival (RFS) rates were estimated using the Kaplan–Meier method. Cox proportional hazards models for OS, metastatic recurrence, and RFS were used. A total of 104 ESCC patients were eligible for the analysis. Of 104 patients, 81 had pT1a-MM, and 23 had pT1b-SM1. The 5-year OS, RFS, and metastatic recurrence rates of the 56 cases of pT1a-MM LVI-negative ESCC without additional treatment were 0.848 (95% confidence interval [CI]: 0.687–0.931), 0.817 (95% CI: 0.647–0.911), and 0.061 (95% CI: 0.014–0.240), respectively. Cox regression analysis for OS, RFS, and metastatic recurrence showed that only lymphatic invasion was strongly associated with metastatic recurrence (adjusted hazard ratio, 10.3; 95% CI: 2.01–53.3; P = .005). The proportion of deaths from other diseases was considerably higher (17/104, 16.3%) than that from ESCC (2/104, 1.9%). This may be related to the high complication rate of malignant tumors in other organs (43.3%, 45/104). The prognosis of ER for pT1a-MM and LVI-negative ESCC is good, and the follow-up policy is valid. Malignant tumors in other organs may be a major prognostic factor for superficial ESCC after ER.
Apatinib combined with temozolomide treatment for pseudoprogression in glioblastoma: A case report
Authors: Zhao Mingming , Ma Haodong , Cheng Peng , Yang Hongjie , Zhao Yang , Han Qian
Published: January 2023

Rationale:

Glioblastoma is the most common malignant tumor of the central nervous system, which originates from glial cells and corresponding precursors. Due to its strong invasion and rapid growth, the prognosis of patients after treatment is very poor and easy to relapse.

Patient concerns:

In August 2015, a 48 years old man with a relapse of glioblastoma.

Diagnoses:

The patient was diagnosed by computed tomography, magnetic resonance imaging, and pathological biopsy in this case report.

Interventions:

The patient underwent 2 surgeries, radiotherapy, and multiple regular chemotherapy sessions over the next 6 years. Apatinib, an inhibitor of vascular endothelial growth factor receptor 2 was given to treat recurrent glioma.

Outcomes:

It was found that radiotherapy combined with temozolomide administration often increased the size of the original lesion or produced a new glioblastoma lesion. The lesion development was similar to tumor progression, which was called pseudoprogression. And it significantly prolonged the survival of this patient.

Lessons:

Surgery, radiotherapy and chemotherapy with apatinib and temozolomide are effective to treat the patients with pseudoprogression in glioblastoma.
The mechanisms of biofilm antibiotic resistance in chronic rhinosinusitis: A review
Authors: Huang Yanlin , Qin Fengfeng , Li Sen , Yin Ji , Hu Lanxin , Zheng Sihan , He Lu , Xia Hui , Liu Jing , Hu Wenjian
Published: January 2023

Chronic rhinosinusitis (CRS) is a common but burdensome ailment that is still poorly understood in terms of its pathogenesis. The existence of biofilms on the sinonasal mucosa of individuals with CRS has been proven by current biofilm identification methods. Current treatments for CRS generally include functional endoscopic sinus surgery, biofilm-removing strategies, and limited therapies that target quorum sensing (QS), patients with CRS are often resistant to antimicrobial therapy at degrees achievable by oral or intravenous administration, and even a subset of patients fail to react to either medical or surgical intervention. Multidrug-resistant Pseudomonas aeruginosa, Staphylococcus aureus, especially methicillin-resistant S. aureus, Streptococcus pneumoniae, and Haemophilus influenzae are the most commonly implicated bacteria in CRS patients, which may lead to the persistence and severity of CRS and antibiotic treatment failure via the formation of biofilms. Resistance to antibiotics is attributed to the 3-dimensional structure and QS of biofilms, and the latter describes the communication of bacteria within biofilms. A better understanding of biofilms in CRS and their contribution to the antibiotic resistance of CRS is critical for novel treatment strategies. This review mainly discusses the special structure of biofilms, QS, and their mechanisms of antibiotic resistance in order to investigate prospective anti-biofilm therapies, suggest future directions for study, and potentially refine the CRS prevention paradigm.
Bladder triangle amyloidosis: A case report and literature review
Authors: Yu Zhi-Yu , Yan Lin , Wang Hua-Kang , Hang Gai , Wang Yu-Yang , Wen Quan , Chen Bo
Published: January 2023

Rationale:

Amyloidosis is a group of benign lesions characterized by extracellular deposition of amyloid proteins. Amyloidosis lesions can occur in various organs of the body, but rarely in the urinary system. Amyloidosis in the bladder trigone is extremely rare.

Patient concerns:

An 80-year-old female patient presented with painless whole-course gross hematuria with reddish urine and no blood clots, accompanied by right lumbar discomfort.

Diagnosis:

Based on the patient’s medical history and cystoscopy findings, the relevant literature was reviewed and a preoperative diagnosis of bladder tumor was made, although bladder amyloidosis was not excluded. Postoperative pathology ultimately revealed bladder amyloidosis.

Interventions:

The patient underwent resection of bladder tumor and ureteral stent implantation. Postoperatively, the patient was maintained on antibiotics and oral colchicine treatment.

Outcomes:

Two months after surgery the patient reported that the gross hematuria had disappeared, and that the right lumbar discomfort was significantly relieved.

Cystoscopy showed no obvious recurrence in the operative area, but magnetic resonance imaging (MRI) suggested recurrence. The patient refused partial cystectomy, and the ureteral stent was removed.

Lesson:

The clinical manifestations of bladder amyloidosis are nonspecific, and under cystoscopy can be easily confused with bladder tumors. Accurate diagnosis of bladder amyloidosis relies on histopathology. Transurethral resection of bladder tumors or partial cystectomy is an option for surgical treatment; the latter should be performed if the ureteral opening is involved.
Observational study to evaluate discontinuation of monotherapy with cobicistat-boosted darunavir in patients with human immunodeficiency virus
Authors: Solana-Altabella Antonio , Monte-Boquet Emilio , Montero Marta , Pérez-Huertas Pablo , Cuéllar-Monreal Maria Jesús , Salavert Miguel , Poveda-Andrés José Luis
Published: January 2023

To evaluate the reasons for changing to monotherapy with protease inhibitors, together with the proportion and reasons for the interruption to treatment, in patients who have been treated at some point with cobicistat-boosted darunavir (DRV/c). Outpatients in a tertiary hospital. Observational retrospective study to evaluate monotherapy with DRV/c (800 mg/150 mg) in adult patients with human immunodeficiency virus infection, from December 2014 to July 2022. Demographic variables, viral load, cluster of differentiation 4 lymphocyte lymphocyte count, and antiretroviral therapy were assessed. 42 patients were included. 36% of the patients were undergoing monotherapy at the time of the analysis. The main reason for discontinuation was poor adherence. At time of analysis, 80% of the patients in monotherapy had an undetectable viral load. Antiretroviral therapy recommendations advise against exposing the patient to functional monotherapy with a single drug due to the high risk of virological failure and the onset of resistance to a single drug. Following the analysis of the results, DRV/c in monotherapy is not an effective strategy in the medium and long term due to factors such as lack of adherence or virological failure, although it can be maintained in specific circumstances. Therefore, patients undergoing monotherapy require close monitoring.
Predicting subacute hematological toxicity of 177Lu-DOTATATE therapy using healthy organs’ uptake on post-treatment quantitative SPECT: A pilot study
Authors: Morland David , Triumbari Elizabeth Katherine Anna , Hoog Christopher , Sézin Ghali , Dejust Sébastien , Cadiot Guillaume , Paris Pierre , Papathanassiou Dimitri
Published: January 2023

The aim is to investigate the usefulness of 177Lu-DOTA-0-Tyr3-Octreotate (DOTATATE) healthy organs’ (spleen, kidneys, bone marrow) standard uptake value for the prediction of subacute hematological toxicity in patients undergoing 177Lu-DOTATATE treatment. All patients referred from January 2021 to May 2022 for 177Lu-DOTATATE treatment were retrospectively screened. For each treatment session, baseline clinical data including age, sex, weight, delay between 177Lu-DOTATATE treatment and last cold somatostatin analogue intake were collected. Mean standardized uptake value (SUVmean) of healthy organs was measured and analyzed by generalized linear mixed effect models. Outcomes (significant decrease of platelets, hemoglobin levels and neutrophils) were assessed 1 month later, considering their within-subject biological coefficient of variation, published by the European Federation of Clinical Chemistry and Laboratory Medicine. A total of 9 patients (33 treatment sessions) were included. No predictive factors were identified for platelet and neutrophil decrease. Splenic SUVmean was found to be a significant predictor of hemoglobin levels decrease. Using an optimal threshold of ≥6.22, derived sensitivity and specificity to predict hemoglobin decrease were 85.7% [46.4; 99.0] and 76.9% [57.5; 89.2] respectively with an accuracy of 82.4%. Although not significantly predictive of hematological toxicity, bone marrow SUVmean and renal SUVmean were correlated with splenic SUVmean. Quantitative single photon emission computed tomography and healthy organs analysis might help to foresee hematological subacute toxicity in patients undergoing 177Lu-DOTATATE treatment and improve patient management.
High-dose chemotherapy followed by autologous stem cell transplantation for adult patients With first relapse of Ewing’s sarcoma: A single institution experience
Authors: Paksoy Nail , Ferhatoglu Ferhat , Dogan İzzet , Khanmammadov Nijat , Iribas Celik Ayca , Gulbas Zafer , Başaran Mert
Published: January 2023

The prognosis of patients with Ewing’s sarcoma family of tumors (ESFT) relapse is poor; the 5-year overall survival (OS) is 13%. We evaluated the effectivity of high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) in adult patients with ESFT relapse. Between January 2010 and January 2021, we retrospectively analyzed 20 patients with ESFT who received HDT upon relapse. A combination of busulfan with melphalan was used as a conditioning regimen before ASCT. The median follow-up from diagnosis and from first relapse was 46.08 months (range; 10.71–186.87) and 14.41 months (range; 4.34–104.11), respectively. The median of age patients was 21.2 years (range, 17.6–25.3), and 10 (50%) patients were female. The tumor originated from the bone in 13 patients and soft tissue in 7 patients. Twelve patients had early (<2 years) relapse, and 8 patients had late (>2 years) relapse. Before HDT, 13 (65%) and 7 (35%) patients had pulmonary and extrapulmonary metastasis, respectively. After induction chemotherapy, 14 patients achieved complete response. The median OS1 and OS2 were 51.6 months (95% confidence interval [CI], range: 16.2–87) and 15.7 months (95% CI, range: 10.2–21.2), respectively. The 1-, 2-, and 5-year OS rates were 50%, 30%, and 15%, respectively. One patient died (sepsis) 1 month after ASCT. In univariate analyses, a disease-free interval (DFI) of < 2 years (P = .008) and incomplete response (P = .021) before ASCT were poor prognostic factors for OS2.HDT with ASCT can result in long-term survival of patients with ESFT relapse. HDT should be considered an important treatment opt ion in patients with a DFI > 2 years and complete response before transplantation.
Scubcutaneous Mycobacterium marinum infection misdiagnosed as sporotrichosis: A case report
Authors: Chen Shi , Liu Zehu , Xia Xiujiao
Published: January 2023

Introduction:

Nontuberculous mycobacteria (NTM), are natural inhabitants of natural waters, engineered water systems, and soils. As a consequence of their ubiquitous distribution, humans are surrounded by these opportunistic pathogens.

Patient concerns:

In this report, we describe a case of scubcutaneous Mycobacterium marinum infection associated with home tropical ornamental fish aquaria. A 43-years-old man reported progressively increasing nodules over his left forearm and hand for more than 7 months.

Diagnosis:

Based on NTM culture, pathological examination, identification by gene sequencing and matrix assisted laser desorption ionization time of flight mass spectrometry, the diagnosis of scubcutaneous NTM infection was confirmed.

Interventions:

The patient was treated with itraconazole for suspected sporotrichosis over 1 month.

Outcomes:

The patient was treated with oral doxycycline hydrochloride capsules (200 mg/day) for 5 months, the nodules had resolved.

Conclusion:

Home aquarium environments may serve as a possible source of mycobacteria infection in urban family.
Sarcopenia using pectoralis muscle area and lymphocyte-to-monocyte ratio (LMR) are independent prognostic factors in patients for nonmetastatic breast cancer
Authors: Song Haa-Na , Kim Ju Yeon , Kim Jae Myung , Kang Ki Mun , Choi Hoon Sik , Jeong Jin Hee , Ha In Bong , Jeong Bae-Kwon
Published: January 2023

Sarcopenia is defined as loss of skeletal muscle mass and strength. This can lead to adverse clinical outcomes in patients with advanced cancer. The lymphocyte-to-monocyte ratio (LMR), a converted inflammatory response, is associated with poor prognosis in patients with malignancies. Herein, we examined the prognostic influence of sarcopenia status assessed by pectoralis muscle area (PMA), inflammatory status calculated by LMR, and its association with disease-free survival (DFS) in a cohort of women diagnosed with nonmetastatic breast cancer. A total of 293 patients with nonmetastatic breast cancer who underwent primary mass resection and radiotherapy between January 2011 and December 2017 were enrolled. The cross-sectional area of the muscle (cm2) at PMA was measured using computed tomography before radiation therapy. Baseline monocyte and lymphocyte counts were obtained from the complete blood count to calculate the LMR. Most of the patients (248/293, 84.6%) underwent breast conservation surgery. Lymph node involvement at diagnosis (hazard ratio [HR], 5.08; P < .001), low LMR (HR, 2.79; P = .007), and low PMA (HR, 3.80; P < .001) were independent poor prognostic factors in multivariate analysis. The mean DFS of sarcopenic and nonsarcopenic patients was 89.8 months and 118.8 months, respectively (P < .001). Sarcopenic patients with low LMR showed the worst outcomes, whereas nonsarcopenic patients with high LMR showed the best outcomes. Low PMA and low LMR were independent poor prognostic factors for DFS in patients with nonmetastatic breast cancer.
Acupuncture for inflammatory bowel disease: A protocol for systematic review and meta-analysis
Authors: Yang Xinyue , Sun Mengmeng , He Min , Wang Zhihong , Tang Qingqing , Li Tie
Published: January 2023

Background:

Inflammatory bowel disease is a prevalent condition that has a major impact on the patient’s life. The conventional drugs for IBD have limits, such as unpleasant events and a difficult recovery. External treatment such as acupuncture, is a traditional Chinese medicine-based therapy in which needles are used to restore the body’s internal balance, and is gaining more and more popularity as a therapeutic option for IBD. However, there is a lack of evidence to support its efficacy and safety in IBD patients. The goal of this systematic review is to assess the evidence of acupuncture’s efficacy and safety for IBD.

Methods:

MEDLINE, the Cochrane library, EMBASE, Web of Science, China National Knowledge Infrastructure, the Chongqing VIP Chinese Science, Technology Periodical Database, the Wanfang database, Japanese medical database, Korean Robotics Institute Summer Scholars, and Thailand Thai-Journal Citation Index Centre will be searched from their inception to 9 November, 2022. Randomized controlled trials evaluating the efficacy of manual acupuncture for patients with IBD, whether or not the blind technique is utilized, will be considered. Language and publication time are both unrestricted. Review Manager (V.5.3.5) will be used by 2 separate researchers to perform article retrieval, duplicate removal, screening, quality evaluation, and data analysis. Efficacy and safety of acupuncture for IBD will be assessed using outcomes including as total effective rate or cure rate, clinical symptom integral (abdominal pain, diarrhea, purulent stool), recurrence rate, inflammatory cytokines, and the Baron and Mayo scores.

Results:

The protocol of this study systematically will assess the effectiveness and safety of acupuncture for IBD.

Conclusion:

This study investigates the efficacy and safety of acupuncture for IBD, providing clinicians and patients with additional options for the treatment of this disease.
A huge chest wall angiomatosis with pleural and rib invasion: A case report
Authors: Wang Yu-Chi , Lin Yun-Nan , Chai Chee-Yin , Li Hsien-Pin , Chen Yi-Ting , Kuo Yur-Ren
Published: January 2023

Rationale:

Angiomatosis is a rare non-neoplastic proliferative vascular lesion that typically develops during childhood or adolescence with a female predominance. Management of angiomatosis is challenging because of the manifestation of a wide variety of lesions as well as their invasive and highly recurrent nature.

Patient concerns:

We report the case of a 74-year-old man who presented with a right lower back mass that persisted for a decade. The mass progressively enlarged and had been painful in the previous month.

Diagnosis:

Computed tomography (CT) revealed suspected lipomatous sarcoma with invasion of the ribs, pleurae, and lung parenchyma. The final pathological examination revealed angiomatosis.

Interventions:

The patient underwent wide composite excision of the tumor along with excision of the pleura and lung nodules in the right lower and middle lobes via video-assisted thoracoscopic surgery (VAST). Fasciocutaneous rotational flap reconstruction was performed immediately after the wide composite excision and video-assisted thoracoscopic surgery (VAST).

Outcomes:

The patient recovered uneventfully, was discharged without complications, and tolerated the daily activities well.

Lessons:

Angiomatosis is a rare benign vascular tumor that frequently mimics malignancy. Even if the patient profile does not match the reported epidemiology of this disease, differential diagnosis should be considered. Complete resection is the mainstay of treatment for the prevention of recurrence.