bluuebunny/crossref_metadata_2025 huggingface dataset:
Alexithymia Is a Key Mediator of the Relationship Between Magical Thinking and Empathy
Authors: Eddy Clare M. , Hansen Peter C.
Published: August 2021

Thought action fusion (TAF), whereby internal thoughts are perceived to exert equivalent effects to external actions, is a form of magical thinking. Psychiatric disorders associated with TAF (e.g. schizophrenia; obsessive compulsive disorder) can feature atypical social cognition. We explored relationships between TAF and empathy in 273 healthy young adults. TAF was directly correlated with higher personal distress, but not perspective taking, fantasy or empathic concern. TAF moral (the belief that thinking about an action/behaviour is morally equivalent to actually performing that behaviour) was predicted by emotion contagion, alexithymia and need for closure. TAF likelihood (the belief that simply having a thought about an event makes that event more likely to occur) was predicted by personal distress, sense of agency and alexithymia. Both cognitive (TAF and negative sense of agency) and emotional (emotion contagion, alexithymia) factors contributed to personal distress. TAF, negative sense of agency and personal distress mediated the effect of emotion contagion on alexithymia. Our findings reveal complex relationships between emotional processes and TAF, shedding further light on the social cognitive profile of disorders associated with magical thinking. Furthermore, they emphasise the potential importance of alexithymia and emotion contagion as mediators or potential risk factors in the development of psychiatric symptoms linked to TAF, such as intrusive thoughts about harm to others.
Older Adults in the United States and COVID-19: A Qualitative Study of Perceptions, Finances, Coping, and Emotions
Authors: Goins R. Turner , Anderson Elizabeth , Minick Hannah , Daniels Heather
Published: August 2021

Introduction: Older adults have the poorest coronavirus (COVID-19) prognosis with the highest risk of death due to complications, making their COVID-19 experiences particularly important. Guided by the stress-appraisal-coping theoretical model, we sought to understand COVID-related perceptions and behaviors of older adults residing in the United States.

Materials and Methods: We used convenience sampling to recruit persons with the following inclusion criteria: Aged ≥ 65 years, English fluency, and U.S. residency. Semi structured in-depth interviews were conducted remotely and audio recorded between April 25, 2020 and May 7, 2020. Interviews were professionally transcribed with a final study sample of 43. A low-inference qualitative descriptive design was used to provide a situated understanding of participants' life experiences using their naturalistic expressions.

Results: The mean age of participants was 72.4 ± 6.7. Slightly over half were female (55.8%), 90.6% were White, and 18.6% lived alone. The largest percentages of participants resided in a rural area (27.9%) or small city (25.6%). We identified four themes, including (1) risk perception, (2) financial impact, (3) coping, and (4) emotions. Most participants were aware of their greater risk for poor COVID-19 outcomes but many did not believe in their increased risk. Financial circumstances because of the pandemic varied with largely no financial impacts, while others reported negative impacts and a few reported positive impacts. Coping was problem- and emotion-focused. Problem-focused coping included precautionary efforts and emotion-focused coping included creating daily structure, pursuing new and/or creative activities, connecting with others in new ways, and minimizing news media exposure. Overall, emotional health was negatively affected by the pandemic although some participants reported positive emotional experiences.

Conclusions: Perceiving themselves as high risk for COVID-19 complications, older adults used precautionary measures to protect themselves from contracting the virus. The precautionary measures included social isolation, which can negatively affect mental health. Older adults will need to be resourceful and draw on existing resources to cope, such as engaging in creative activities and new strategies to connect with others. Our findings underscore the importance of the preservation of mental health during extended periods of isolation by taking advantage of low-to-no-cost existing resources.
Individual Differences in Children’s (Language) Learning Skills Moderate Effects of Robot-Assisted Second Language Learning
Authors: van den Berghe Rianne , Oudgenoeg-Paz Ora , Verhagen Josje , Brouwer Susanne , de Haas Mirjam , de Wit Jan , Willemsen Bram , Vogt Paul , Krahmer Emiel , Leseman Paul
Published: August 2021

The current study investigated how individual differences among children affect the added value of social robots for teaching second language (L2) vocabulary to young children. Specifically, we investigated the moderating role of three individual child characteristics deemed relevant for language learning: first language (L1) vocabulary knowledge, phonological memory, and selective attention. We expected children low in these abilities to particularly benefit from being assisted by a robot in a vocabulary training. An L2 English vocabulary training intervention consisting of seven sessions was administered to 193 monolingual Dutch five-year-old children over a three- to four-week period. Children were randomly assigned to one of three experimental conditions: 1) a tablet only, 2) a tablet and a robot that used deictic (pointing) gestures (the no-iconic-gestures condition), or 3) a tablet and a robot that used both deictic and iconic gestures (i.e., gestures depicting the target word; the iconic-gestures condition). There also was a control condition in which children did not receive a vocabulary training, but played dancing games with the robot. L2 word knowledge was measured directly after the training and two to four weeks later. In these post-tests, children in the experimental conditions outperformed children in the control condition on word knowledge, but there were no differences between the three experimental conditions. Several moderation effects were found. The robot’s presence particularly benefited children with larger L1 vocabularies or poorer phonological memory, while children with smaller L1 vocabularies or better phonological memory performed better in the tablet-only condition. Children with larger L1 vocabularies and better phonological memory performed better in the no-iconic-gestures condition than in the iconic-gestures condition, while children with better selective attention performed better in the iconic-gestures condition than the no-iconic-gestures condition. Together, the results showed that the effects of the robot and its gestures differ across children, which should be taken into account when designing and evaluating robot-assisted L2 teaching interventions.
Seasonal Nitrous Oxide Emissions From Hydroponic Tomato and Cucumber Cultivation in a Commercial Greenhouse Company
Authors: Karlowsky Stefan , Gläser Markus , Henschel Klaus , Schwarz Dietmar
Published: August 2021

Nitrous oxide (N2O) is considered as the most critical greenhouse gas (GHG) emitted by agricultural and horticultural food production. Hydroponic vegetable cultivation in greenhouse systems has a high potential for N2O emissions due to the intense application of nitrogen-containing fertilizers. Previous studies on model hydroponic systems indicate that N2O emissions per unit area can be several times higher than typically found during field cultivation. However, reliable data from production-scale hydroponic systems is missing. Here we report our findings from monitoring the N2O emissions in a commercial production greenhouse, located in the east of Germany, over a period of 1 year. We used the static chamber method to estimate N2O fluxes in the root zones of hydroponic tomato and cucumber cultures on rock wool growing bags with drip fertigation. Regular sampling intervals (weekly-biweekly) were used to calculate whole season cumulative N2O emissions and N2O emission factors (EFs) based on the amount of nitrogen fertilizer applied. Our results indicate that the seasonal N2O emissions from hydroponic greenhouse cultivation are considerably smaller than expected from previous studies. In total, we estimated average cumulative N2O emissions of 2.3 and 1.5 kg N2O–N ha−1 yr−1 for tomato and cucumber cultures, respectively. Average EFs were 0.31% for tomato cultivation with drain re-use (closed hydroponic system), and 0.13% for cucumber cultivation without drain re-use (open hydroponic system). These values lie below the general EF for N2O from agricultural soils, noted with 1% by the intergovernmental panel on climate change (IPCC). In conclusion, considering the high yield of greenhouse cultivation, hydroponic systems provide a way of producing vegetables climate-friendly, in terms of direct GHG emissions. Further attention should be given to reducing energy inputs, e.g., by using regenerative sources or thermal discharge from industrial processes, and to increasing circularity, e.g., by using recycling fertilizers derived from waste streams. Especially in urban and peri-urban areas, the use of hydroponics is promising to increase local and sustainable food production.
Amendment Properties Affect Crop Performance, Leaf Tissue Nitrogen, and Soil Nitrogen Availability Following Soil Treatment by Anaerobic Soil Disinfestation
Authors: Shrestha Utsala , Swilling Keagan J. , Butler David M.
Published: August 2021

Efficacy of anaerobic soil disinfestation (ASD) for soilborne plant pathogen suppression is strongly influenced by soil environment and organic amendment attributes. At the same time, these factors influence soil nutrient availability, crop nutrition, and crop performance, but published information on ASD amendment property effects, including carbon to nitrogen (C:N) ratio and C substrate bioavailability, on crop performance and soil nutrient availability is limited. We evaluated ASD amendment effects on soil N availability, crop N status, and solanaceous crop performance in a series of trials: (1) greenhouse/growth chamber study of amendments (primarily molasses/soybean hulls and wheat bran) formulated at 10:1, 20:1, 30:1 and 40:1 C:N ratios (4 mg C g−1 soil), (2) field study with molasses/soybean hull-based amendments at equivalent C:N ratios/C rates (3) on-farm study with molasses/soybean hull-based amendments (4 mg C g−1 soil) compared to grower-standard control, and (4) field study of labile to recalcitrant amendment substrates at 30:1 C:N ratio (~3.4 mg C g−1 soil). ASD amendment C:N ratio strongly influenced soil inorganic N and the lowest (10:1) ratio was associated with highest soil inorganic N at ASD treatment termination in both trials 1 and 2, which often persisted into the cropping phase. Accordingly, the lowest amendment C:N ratio was also associated with the highest biomass (trail 1), leaf tissue N (trial 2), and crop yield (trials 1, 2) among treatments, even with application of recommended fertigation rates to all treatments in the field study. In trial 3, ASD treatment induced higher soil inorganic N and crop yield than the control, but no differences were observed in plant tissue N. In trial 4, more decomposable ASD substrates reduced soil inorganic N at ASD treatment termination, with the highest soil inorganic N associated with the most recalcitrant amendment, but there was no effect on crop yield. ASD amendment C:N ratio, and to a lesser extent, amendment decomposability, exert a strong influence soil inorganic N and crop performance. Optimization of ASD treatments for disease management will require simultaneous optimization of crop nutrition practices to facilitate more holistic, less confounded assessment of crop performance and to facilitate recommendations for grower adoption.
Grazing in California's Mediterranean Multi-Firescapes
Authors: Huntsinger Lynn , Barry Sheila
Published: August 2021

The California landscape is layered and multifunctional, both historically and spatially. Currently, wildfire size, frequency, and intensity are without precedent, at great cost to human health, property, and lives. We review the contemporary firescape, the indigenous landscape that shaped pre-contact California's vegetation, the post-contact landscape that led us to our current situation, and the re-imagined grazing-scape that offers potential relief. Vegetation has been profoundly altered by the loss of Indigenous management, introduction of non-native species, implantation of inappropriate, militarized, forest management from western Europe, and climate change, creating novel ecosystems almost always more susceptible to wildfire than before. Vegetation flourishes during the mild wet winters of a Mediterranean climate and dries to a crisp in hot, completely dry, summers. Livestock grazing can break up continuous fuels, reduce rangeland fuels annually, and suppress brush encroachment, yet it is not promoted by federal or state forestry and fire-fighting agencies. Agencies, especially when it comes to fire, operate largely under a command and control model, while ranchers are a diverse group not generally subject to agency regulations, with a culture of autonomy in decision-making and a unit of production that is mobile. Concerns about potential loss of control have limited prescribed burning despite landowner and manager enthusiasm. Agriculture and active management in general are much neglected as an approach to developing fire-resistant landscape configurations, yet such interventions are essential. Prescribed burning facilitates grazing; grazing facilitates prescribed burning; both can reduce fuels. Leaving nature “to itself” absent recognizing that California's ecosystems have been irrecoverably altered has become a disaster of enormous proportions. We recommend the development of a database of the effects and uses of prescribed fire and grazing in different vegetation types and regions throughout the state, and suggest linking to existing databases when possible. At present, livestock grazing is California's most widespread vegetation management activity, and if purposefully applied to fuel management has great potential to do more.
Advances in Skin Tissue Bioengineering and the Challenges of Clinical Translation
Authors: Dearman Bronwyn L. , Boyce Steven T. , Greenwood John E.
Published: August 2021

Skin tissue bioengineering is an emerging field that brings together interdisciplinary teams to promote successful translation to clinical care. Extensive deep tissue injuries, such as large burns and other major skin loss conditions, are medical indications where bioengineered skin substitutes (that restore both dermal and epidermal tissues) are being studied as alternatives. These may not only reduce mortality but also lessen morbidity to improve quality of life and functional outcome compared with the current standards of care. A common objective of dermal-epidermal therapies is to reduce the time required to accomplish stable closure of wounds with minimal scar in patients with insufficient donor sites for autologous split-thickness skin grafts. However, no commercially-available product has yet fully satisfied this objective. Tissue engineered skin may include cells, biopolymer scaffolds and drugs, and requires regulatory review to demonstrate safety and efficacy. They must be scalable for manufacturing and distribution. The advancement of technology and the introduction of bioreactors and bio-printing for skin tissue engineering may facilitate clinical products' availability. This mini-review elucidates the reasons for the few available commercial skin substitutes. In addition, it provides insights into the challenges faced by surgeons and scientists to develop new therapies and deliver the results of translational research to improve patient care.
Case Report: Metastatic Parosteal Osteosarcoma in a Dog
Authors: Samuels Sarah K. , Cook Matthew R. , Green Eric , Jennings Ryan , Pool Roy R. , Wavreille Vincent A. , Kisseberth William C. , Selmic Laura E.
Published: August 2021

This case report describes a rare form of malignant bone tumor in an 8-year-old Labrador retriever. This dog initially presented for evaluation of a right distal humeral mass. Radiographs of the right elbow and thorax were performed, revealing a smooth mineralized mass adjacent to the lateral aspect of the distal humerus and a 5mm pulmonary nodule. Computed tomography (CT) of the humerus and thorax showed a smooth mineralized lesion adjacent to the lateral humeral epicondyle, and a right cranial lung lobe nodule with a thin mineral rim. Surgical biopsies of both lesions were diagnostic for parosteal osteosarcoma (POSA). The dog was then treated with stereotactic body radiation therapy (SBRT) which controlled the dog's discomfort for 14 months until he became progressively painful and subsequently had his right forelimb amputated. This case report is the first to document the CT imaging characteristics of a metastatic appendicular POSA in a dog and the first dog described with POSA treated with SBRT. The dog lived for 623 days after histopathologic diagnosis and 849 days after initial presentation with pulmonary metastatic disease.
Chitosan Augments Tetramycin against Soft Rot in Kiwifruit and Enhances Its Improvement for Kiwifruit Growth, Quality and Aroma
Authors: Wang Qiuping , Zhang Cheng , Wu Xiaomao , Long Youhua , Su Yue
Published: August 2021

In this study, the co–application of chitosan and tetramycin against kiwifruit soft rot and its effects on the disease resistance, growth, quality and aroma of kiwifruit were investigated. The results show that chitosan could effectively enhance tetramycin against soft rot of kiwifruit with the field control efficacy of 85.33% for spraying chitosan 100 time + 0.3% tetramycin AS 5000–time dilution liquid, which was higher than 80.99% for 0.3% tetramycin AS 5000–time dilution liquid and significantly (p < 0.01) higher than 40.66% for chitosan 100–time dilution liquid. Chitosan could significantly (p < 0.05) improve the promoting effects of tetramycin on total phenolics, total flavonoids, SOD activity of kiwifruit compared to tetramycin during storage for 0–28 days and enhance the disease resistance of kiwifruit. Moreover, the co–application of chitosan and tetramycin was more effective than tetramycin or chitosan alone in enhancing fruit growth, improving fruit quality and increasing fruit aroma. This study highlights that chitosan can be used as an adjuvant to enhance tetramycin against soft rot of kiwifruit and promote tetramycin’s improvement for the single fruit volume and weight, vitamin C, soluble sugar, soluble solid, dry matter, soluble protein, titratable acidity and aroma of kiwifruit.
PDMS Bonding Technologies for Microfluidic Applications: A Review
Authors: Borók Alexandra , Laboda Kristóf , Bonyár Attila
Published: August 2021

This review summarizes and compares the available surface treatment and bonding techniques (e.g., corona triggered surface activation, oxygen plasma surface activation, chemical gluing, and mixed techniques) and quality/bond-strength testing methods (e.g., pulling test, shear test, peel test, leakage test) for bonding PDMS (polydimethylsiloxane) with other materials, such as PDMS, glass, silicon, PET (polyethylene terephthalate), PI (polyimide), PMMA (poly(methyl methacrylate)), PVC (polyvinyl chloride), PC (polycarbonate), COC (cyclic olefin copolymer), PS (polystyrene) and PEN (polyethylene naphthalate). The optimized process parameters for the best achievable bond strengths are collected for each substrate, and the advantages and disadvantages of each method are discussed in detail.
Prospective Evaluation of Radiotherapy-Induced Immunologic and Genetic Effects in Colorectal Cancer Oligo-Metastatic Patients with Lung-Limited Disease: The PRELUDE-1 Study
Authors: Ottaiano Alessandro , Petito Angela , Santorsola Mariachiara , Gigantino Valerio , Capuozzo Maurizio , Fontanella Daniela , Di Franco Rossella , Borzillo Valentina , Buonopane Sergio , Ravo Vincenzo , Scipilliti Esmeralda , Totaro Giuseppe , Serra Marcello , Ametrano Gianluca , Penta Roberta , Tatangelo Fabiana , Scognamiglio Giosuè , Di Mauro Annabella , Di Bonito Maurizio , Napolitano Maria , Scala Stefania , Rea Giuseppina , Santagata Sara , Lombardi Angela , Grimaldi Anna , Caputo Carlo , Crispo Anna , Celentano Egidio , De Feo Gianfranco , Circelli Luisa , Savarese Giovanni , Ruggiero Raffaella , Perri Francesco , Granata Vincenza , Botti Gerardo , Caraglia Michele , Nasti Guglielmo , Muto Paolo
Published: August 2021

Background: in recent years, the management of advanced colorectal cancer (CRC) has been greatly improved with integrated strategies including stereotactic radiation therapy (SRT). The administration of SRT has been demonstrated, particularly in oligo-metastatic (om) CRC, to be a safe and effective option. Interestingly, it has been demonstrated that SRT can induce regression of tumors in non-irradiated regions (“abscopal effect”) through stimulation of anti-tumor immune effects (“radiation-induced immunity”). We have recently shown that lung-limited omCRC is characterized by regression of tumor clones bearing specific key driver gene mutations. Aims: to assess the genetic evolution on tumor cancer cells induced by SRT in lung-limited omCRC. Secondary objectives included descriptions of the abscopal effect, responses’ duration, toxicity, and progression-free survival. A translational research will be performed to evaluate tumor genetic evolution (through liquid biopsies and Next Generation Sequencing), HLA class I repertoire, peripheral immune cells, and cytokine dynamics. Methods: PRELUDE-1 is a prospective translational study. SRT will be administered only to the largest nodule (with a maximum diameter ≤ 25 mm) in omCRC with two or three radiologically evident lesions. The sample size is based on the innovative hypothesis that radiation-induced immunity could induce regression of tumor clones bearing KRAS oncogene mutations. According to the binomial test, considering the frequency of KRAS mutations and assuming a probability of mutant KRAS→wild type KRAS of p0 = 0.0077, with α = 0.05 and 1-β = 0.60, the final sample size is 25 patients.
Epigenetic Changes Affecting the Development of Hepatocellular Carcinoma
Authors: Wolinska Ewa , Skrzypczak Maciej
Published: August 2021

Hepatocellular carcinoma (HCC) remains a serious oncologic issue with still a dismal prognosis. So far, no key molecular mechanism that underlies its pathogenesis has been identified. Recently, by specific molecular approaches, many genetic and epigenetic changes arising during HCC pathogenesis were detected. Epigenetic studies revealed modified methylation patterns in HCC tumors, dysfunction of enzymes engaged in the DNA methylation process, and a set of histone modifications that influence gene expression. HCC cells are also influenced by the disrupted function of non-coding RNAs, such as micro RNAs and long non-coding RNAs. Moreover, a role of liver cancer stem cells in HCC development is becoming evident. The reversibility of epigenetic changes offers the possibility of influencing them and regulating their undesirable effects. All these data can be used not only to identify new therapeutic targets but also to predict treatment response. This review focuses on epigenetic changes in hepatocellular carcinoma and their possible implications in HCC therapy.
Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction
Authors: Mizuno Masahiro , Khaledian Behnoush , Maeda Masao , Hayashi Takanori , Mizuno Seiya , Munetsuna Eiji , Watanabe Takashi , Kono Seishi , Okada Seiji , Suzuki Motoshi , Takao Shintaro , Minami Hironobu , Asai Naoya , Sugiyama Fumihiro , Takahashi Satoru , Shimono Yohei
Published: August 2021

Adipose tissue is a component of the tumor microenvironment and is involved in tumor progression. We have previously shown that adipokine adipsin (CFD) functions as an enhancer of tumor proliferation and cancer stem cell (CSC) properties in breast cancers. We established the Cfd-knockout (KO) mice and the mammary adipose tissue-derived stem cells (mADSCs) from them. Cfd-KO in mADSCs significantly reduced their ability to enhance tumorsphere formation of breast cancer patient-derived xenograft (PDX) cells, which was restored by the addition of Cfd in the culture medium. Hepatocyte growth factor (HGF) was expressed and secreted from mADSCs in a Cfd-dependent manner. HGF rescued the reduced ability of Cfd-KO mADSCs to promote tumorsphere formation in vitro and tumor formation in vivo by breast cancer PDX cells. These results suggest that HGF is a downstream effector of Cfd in mADSCs that enhances the CSC properties in breast cancers.
CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia
Authors: D’Arena Giovanni , Vitale Candida , Coscia Marta , Lamorte Daniela , Pietrantuono Giuseppe , Perutelli Francesca , D’Auria Fiorella , Statuto Teodora , Valvano Luciana , Tomasso Annamaria , Griggio Valentina , Jones Rebecca , Mansueto Giovanna , Villani Oreste , D’Agostino Simona , Viglioglia Vito , De Feo Vincenzo , Calapai Fabrizio , Mannucci Carmen , Sgambato Alessandro , Efremov Dimitar G. , Laurenti Luca
Published: August 2021

Membrane-bound CD200 is overexpressed in chronic lymphocytic leukemia (CLL), and there is some evidence that its soluble ectodomain (sCD200) could also be involved in the pathophysiology and the disease. However, very little is known about sCD200’s prognostic significance. sCD200 was tested at diagnosis in 272 patients with CLL and in 78 age- and sex-matched healthy subjects using a specific human CD200 (OX-2 membrane glycoprotein) ELISA kit. A significantly higher concentration of sCD200 was found in CLL patients compared to controls. In our cohort, sCD200 was significantly higher in patients who were older than 66 years, with Binet stage C, unmutated IgVH and unfavorable (del11q or del17p) FISH. Time-to-first treatment and overall survival were significantly shorter in patients with higher sCD200 concentration, using as a cut-off 1281 pg/mL, the median value for sCD200 concentration in the whole CLL cohort. However, the prognostic impact of sCD200 was not confirmed in multivariate analysis. Baseline sCD200 values appeared to have an impact on the response to chemotherapy or chemo-immunotherapy, but not to targeted agents. Collectively, our data show that sCD200 serum levels correlate with more aggressive clinical and biological features and are able to predict a worse prognosis. This work supports the relevant role of CD200 not only as a diagnostic tool but also as a prognostic indicator and a potential therapeutic target in CLL.
Addendum: Gouriou et al. ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury. Cells 2020, 9, 2542
Authors: Gouriou Yves , Alam Muhammad Rizwan , Harhous Zeina , Da Silva Claire Crola , Baetz Delphine , Badawi Sally , Lefai Etienne , Rieusset Jennifer , Durand Annie , Harisseh Rania , Gharib Abdallah , Ovize Michel , Bidaux Gabriel
Published: August 2021

The authors and the Cells Editorial Office would like to add the section “Materials and Methods”, which was missing in the original version [...]
Examining Recruitment Practices for Servingness during COVID-19: Perspectives from Institutional Agents at an Emerging Hispanic-Serving Institution (HSI)
Authors: Deeb-Sossa Natalia , Cuellar Marcela G. , Nuñez Martinez Mayra , Sanchez Nava Yadira , Guerrero Blas G.
Published: August 2021

The COVID-19 pandemic hit in March 2020 as high school seniors were receiving their college admission notifications for fall. Many postsecondary institutions shifted outreach efforts to online formats. This qualitative study examines how virtual recruitment at an emerging HSI incorporates culturally responsive practices from the perspective of institutional agents (IAs) who were involved in these efforts. We also consider how IAs perceive the broader commitment of the institution to serve Latinx/a/o students. Our findings expose limitations in effectively recruiting Latinx/a/os in virtual formats due to the digital divide. The IAs identify ways in which the university was not equipped to overcome unreliable broadband access and technology. These agents maintain a critical lens to identify how the institution can expand capacity and ensure that the work of supporting Latinx/a/o students is a shared responsibility and not concentrated on a few staff. The findings further raise awareness of the continued language divide in disseminating information to families who do not speak English. Our study provides insights on how universities nationwide and across the world can transform recruitment practices to more intentionally support minoritized students and families as they make enrollment decisions into college.
Willingness to Take COVID-19 Vaccines in Ethiopia: An Instrumental Variable Probit Approach
Authors: Oyekale Abayomi Samuel
Published: August 2021

This paper analyzed the factors influencing the willingness of Ethiopia’s population to take COVID-19 vaccines. The data included the COVID-19 High Frequency Phone Survey of Households in Ethiopia that were collected in 2021. This paper relied on the 10th round of the survey, which was comprised of 2178 households. The Instrumental Variable Probit regression model was used to analyze the data. The results showed that majority of the respondents (92.33%) would receiveCOVID-19 vaccines, while 6.61% and 1.06% were, respectively, unwilling and unsure. Across the regions of Ethiopia, Southern Nations, Nationalities, and Peoples’ Region (SNNPR) (99.30%), Oromia (97.54%), Tigray (97.04%) and Gambela (95.42%) had the highest proportions of respondents willing to have the vaccine. Vaccine safety concern was the topmost reason for those unwilling to receive the vaccine. The results of the Instrumental Variable Probit regression showed that currently working, age, engagement with non-farm businesses and region of residence significantly influenced the population’s willingness to take the vaccine (p < 0.05). It was concluded that although the willingness be vaccinated was impressive, without everyone being receiving the COVID-19 vaccine, infection risk can still be high; this is due to the persistent mutation of the viral strains. Thus, there is a need to intensify efforts toward addressing the safety issues of COVID-19 vaccines, while efforts to enhance acceptability should focus on the youth population and those who are unemployed.
Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans
Authors: Pickering Marie-Eva
Published: August 2021

Magnesium (Mg) is a pivotal and very complex component of healthy aging in the cardiovascular-muscle-bone triad. Low Mg levels and low Mg intake are common in the general aging population and are associated with poorer outcomes than higher levels, including vascular calcification, endothelial dysfunction, osteoporosis, or muscle dysfunction/sarcopenia. While Mg supplementation appears to reverse these processes and benefit the triad, more randomized clinical trials are needed. These will allow improvement of preventive and curative strategies and propose guidelines regarding the pharmaceutical forms and the dosages and durations of treatment in order to optimize and adapt Mg prescription for healthy aging and for older vulnerable persons with comorbidities.
RNA Binding Properties of the Ty1 LTR-Retrotransposon Gag Protein
Authors: Gumna Julita , Andrzejewska-Romanowska Angelika , Garfinkel David J. , Pachulska-Wieczorek Katarzyna
Published: August 2021

A universal feature of retroelement propagation is the formation of distinct nucleoprotein complexes mediated by the Gag capsid protein. The Ty1 retrotransposon Gag protein from Saccharomyces cerevisiae lacks sequence homology with retroviral Gag, but is functionally related. In addition to capsid assembly functions, Ty1 Gag promotes Ty1 RNA dimerization and cyclization and initiation of reverse transcription. Direct interactions between Gag and retrotransposon genomic RNA (gRNA) are needed for Ty1 replication, and mutations in the RNA-binding domain disrupt nucleation of retrosomes and assembly of functional virus-like particles (VLPs). Unlike retroviral Gag, the specificity of Ty1 Gag-RNA interactions remain poorly understood. Here we use microscale thermophoresis (MST) and electrophoretic mobility shift assays (EMSA) to analyze interactions of immature and mature Ty1 Gag with RNAs. The salt-dependent experiments showed that Ty1 Gag binds with high and similar affinity to different RNAs. However, we observed a preferential interaction between Ty1 Gag and Ty1 RNA containing a packaging signal (Psi) in RNA competition analyses. We also uncover a relationship between Ty1 RNA structure and Gag binding involving the pseudoknot present on Ty1 gRNA. In all likelihood, the differences in Gag binding affinity detected in vitro only partially explain selective Ty1 RNA packaging into VLPs in vivo.
Intravitreal Dexamethasone Implants for Refractory Macular Edema in Eyes with Noninfectious Uveitis
Authors: Kang Eugene Yu-Chuan , Garg Sunir J. , Chen Hsi-Fu , Wu Wei-Chi , Chen Linda Yi-Hsing , Chou Hung-Da , Liu Laura , Chen Kuan-Jen , Hwang Yih-Shiou
Published: August 2021

Macular edema (ME) is a common cause of visual loss among eyes with uveitis, and its management can be challenging. Steroids are an effective treatment for ME, and intravitreal dexamethasone (DEX) implants provide sustained steroid release. The purpose of this study is to evaluate intravitreal DEX implant on refractory ME in eyes with noninfectious uveitis. A retrospective study including 52 eyes of 37 patients with refractory uveitic ME was conducted from January 2011 through August 2017 at Linkou Chang Gung Memorial Hospital in Taiwan. Patients’ demographic characteristics were collected. In addition, clinical information, including corrected visual acuity (VA), intraocular pressure (IOP), and central retinal thickness (CRT) on optical coherence tomography, was recorded and analyzed. During the study period, affected eyes received a total of 110 intravitreal DEX implants (range, one to six in each eye). After the first DEX implant injection in all eyes, VA significantly improved at one and two months. CRT significantly decreased one month after a single DEX implant, and the effect lasted for six months and waned over time. Patients receiving multiple DEX implants still showed significant decreases in CRT one month after the first implant. Increases in IOP were noted one month after the DEX implant, but the IOP could be medically controlled. Intravitreal DEX implants can effectively treat refractory uveitic ME, improving both VA and CRT with an acceptable safety profile. Further studies are necessary to evaluate the effect of multiple implants and long-term outcomes.
Pyuria as a Predictive Marker of Bacillus Calmette–Guérin Unresponsiveness in Non-Muscle Invasive Bladder Cancer
Authors: Suh Jungyo , Yuk Hyeong Dong , Jeong Chang Wook , Kwak Cheol , Kim Hyeon Hoe , Ku Ja Hyeon
Published: August 2021

This study aims to investigate the clinical role of preoperative pyuria for predicting bacillus Calmette–Guérin (BCG) unresponsiveness in non-muscle invasive bladder cancer (NMIBC). We performed a logistic regression analysis on 453 patients with NMIBC who were treated with BCG immunotherapy after a transurethral resection of bladder tumours, to evaluate predictive factors of BCG unresponsiveness. We also analysed univariate and multivariable survival data to estimate the prognostic impact of pyuria. Of the total study population, 37.6% (170/453) of patients had BCG unresponsiveness. A multivariable logistic regression analysis revealed that a history of upper urinary tract cancer (odds ratio (OR): 1.86, 95% confidence interval (CI): 1.04–3.32, p-value = 0.035) and the presence of pyuria (OR: 1.51, 95% CI: 1.01–2.27, p = 0.047) and tumour multiplicity (OR: 1.80, 95% CI: 1.18–2.75, p-value < 0.001) were significant predictors of BCG unresponsiveness. A Cox proportional hazards analysis model showed that pyuria was a significant prognostic factor for progression-free survival (hazard ratio: 4.51, 95% CI: 1.22–16.66, p = 0.024). A history of upper urinary tract cancer and the presence of pyuria and tumour multiplicity are predictive markers of BCG unresponsiveness. For patients with NMIBC who have preoperative pyuria, treatment using BCG should be considered cautiously.
Effects of Physiotherapy vs. Acupuncture in Quality of Life, Pain, Stiffness, Difficulty to Work and Depression of Women with Fibromyalgia: A Randomized Controlled Trial
Authors: Garrido-Ardila Elisa María , González-López-Arza María Victoria , Jiménez-Palomares María , García-Nogales Agustín , Rodríguez-Mansilla Juan
Published: August 2021

Background: Fibromyalgia is a chronic clinical condition characterized by pain and other associated symptoms that have a negative impact on the quality of life of the affected person. The objective of this study was to assess the effectiveness of a core stability training physiotherapy program compared to an acupuncture treatment on quality of life, pain, joint stiffness, difficulty to work and depression of women with fibromyalgia. Methods: This was a single-blind, randomized clinical controlled trial. Women with fibromyalgia were randomized to a core stability physiotherapy program group (n = 45), an acupuncture treatment group (n = 45) and a control group (n = 45) for 13 weeks. Measurements were taken at baseline (week 0), post-intervention (week 6) and at follow-up (week 13). The primary outcome measure was quality of life (Spanish Fibromyalgia Impact Questionnaire). The secondary outcome measures were pain, joint stiffness, difficulty to work and depression (Visual Analogue Scale). Results: In total, 103 participants completed the study. The results, from a descriptive perspective, showed improvements in all the outcome measures in both intervention groups (physiotherapy and acupuncture) at weeks 6 and 13 in relation to week 0 and in comparison to the control group. Only the difficulty to work measure in the acupuncture group showed a slight decrease at week 13. In particular, mean (±SD) Spanish Fibromyalgia Impact Questionnaire score at 6 weeks was 62.89 ± 16.91 for the physiotherapy group, 62.5 ± 18.09 for the acupuncture group and 67.45 ± 17.07 for the control group. However, these improvements were not statistically significant. Conclusion: Core stability-based physiotherapy and acupuncture showed non-significant improvements in quality of life, pain, joint stiffness, difficulty to work and depression in women with fibromyalgia.
Is 0.01% Atropine an Effective and Safe Treatment for Myopic Children? A Systemic Review and Meta-Analysis
Authors: Tsai Hou-Ren , Chen Tai-Li , Wang Jen-Hung , Huang Huei-Kai , Chiu Cheng-Jen
Published: August 2021

Several conflicting results regarding the efficacy of 0.01% atropine in slowing axial elongation remain in doubt. To solve this issue and evaluate the safety of 0.01% atropine, we conducted a systematic review and meta-analysis with the latest evidence. The review included a total of 1178 participants (myopic children). The efficacy outcomes were the mean annual progression in standardized equivalent refraction (SER) and axial length (AL). The safety outcomes included mean annual change in accommodative amplitude, photopic and mesopic pupil diameter. The results demonstrated that 0.01% atropine significantly retarded SER progression compared with the controls (weighted mean difference [WMD], 0.28 diopter (D) per year; 95% confidence interval (CI) = 0.17, 0.38; p < 0.01), and axial elongation (WMD, −0.06 mm; 95% CI = −0.09, −0.03; p < 0.01) during the 1-year period. Patients receiving 0.01% atropine showed no significant changes in accommodative amplitude (WMD, −0.45 D; 95% CI = −1.80, 0.90; p = 0.51) but showed dilated photopic pupil diameter (WMD, 0.35 mm; 95% CI = 0.02, 0.68; p = 0.04) and mesopic pupil diameter (WMD, 0.20 mm; 95% CI = 0.08, 0.32; p < 0.01). In the subgroup analysis of SER progression, myopic children with lower baseline refraction (>−3 D) and older age (>10-year-old) obtained better responses with 0.01% atropine treatment. Furthermore, the European and multi-ethnicity groups showed greater effect than the Asian groups. In conclusion, 0.01% atropine had favorable efficacy and adequate safety for childhood myopia over a 1-year period.
Market Liquidity and Its Dimensions: Linking the Liquidity Dimensions to Sentiment Analysis through Microblogging Data
Authors: Guijarro Francisco , Moya-Clemente Ismael , Saleemi Jawad
Published: August 2021

Market liquidity has an immediate impact on the execution of transactions in financial markets. Informed counterparty risk is often priced into market liquidity. This study investigates whether microblogging data, as a non-financial information tool, is priced along with market liquidity dimensions. The analysis is based on the Australian Securities Exchange (ASX), and from the results, we conclude that microblogging content in pessimistic periods has a higher impact on liquidity and its dimensions. On a daily basis, pessimistic investor sentiments lead to higher trading costs, illiquidity, a larger price dispersion and a lower trading volume.
Relativized Prosodic Domains: A Late-Insertion Account of German Plurals
Authors: Schuhmann Katharina S. , Putnam Michael T.
Published: August 2021

In late-insertion, realizational models of morphology such as Distributed Morphology (DM), the insertion of Vocabulary Items (VIs) is conditioned by cyclic operations in the syntax. This paper explores whether an isomorphic relationship can be established between cyclic operations such as phases and prosodic domains. In the spirit of D’Alessandro and Scheer’s (2015) proposal of a Modular Phase Impenetrability Condition (MPIC), we strive to provide an analysis in which prosodic boundaries in even smaller, word-level-like syntactic structures—the ‘lexical domain’—can be identified solely within the syntax. We propose a DM-account for the distribution of nominal plural exponency in German, which reveals a dominant trend for a trochaic-foot structure for all but -s-plural exponents (Wiese 2001, 2009). Inspired by Gouskova’s (2019) and Svenonius’ (2016) work concerning the prosody–morphology interface, we argue that the index of a Prosodic Word ω in non-s-plurals is associated with a specific feature configuration. We propose that only a n[+pl(ural)] configuration, in which the nominalizing head n hosts the SynSem-feature Num(ber)[+pl(ural)], rather than a general cyclic categorizing phase head such as n, indexes a Prosodic Word ω for nominal plural exponents in (Standard) German. Based on this empirical evidence from German plural exponency, we argue that (i) prosodic boundaries can be established directly by syntactic structures, (ii) these prosodic boundaries condition VI insertion during the initial stages of Spell-Out, and (iii) prosodic domains are based on individual languages’ syntactic structures and feature configurations, and are thus relativized and language-specific in nature.
Textual Data Science for Logistics and Supply Chain Management
Authors: Treiblmaier Horst , Mair Patrick
Published: August 2021

Background: Researchers in logistics and supply chain management apply a multitude of methods. So far, however, the potential of textual data science has not been fully exploited to automatically analyze large chunks of textual data and to extract relevant insights. Methods: In this paper, we use data from 19 qualitative interviews with supply chain experts and illustrate how the following methods can be applied: (1) word clouds, (2) sentiment analysis, (3) topic models, (4) correspondence analysis, and (5) multidimensional scaling. Results: Word clouds show the most frequent words in a body of text. Sentiment analysis can be used to calculate polarity scores based on the sentiments that the respondents had in their interviews. Topic models cluster the texts based on dominating topics. Correspondence analysis shows the associations between the words being used and the respective managers. Multidimensional scaling allows researchers to visualize the similarities between the interviews and yields clusters of managers, which can also be used to highlight differences between companies. Conclusions: Textual data science can be applied to mine qualitative data and to extract novel knowledge. This can yield interesting insights that can supplement existing research approaches in logistics and supply chain research.
HPLC-Analysis, Biological Activities and Characterization of Action Mode of Saudi Marrubium vulgare against Foodborne Diseases Bacteria
Authors: Al-Zaban Mayasar , Naghmouchi Souheila , AlHarbi Nada K.
Published: August 2021

The present study aims to evaluate the chemical composition, metabolites secondary and pharmacology activities of methanolic extract of Marrubium vulgare collected from King Saudi Arabia. Moreover, the primary mode of action of the tested extract was studied here for the first time against E. coli and L. monocytogenes. HPLC analysis shows that the major components in the tested extract are luteolin-7-O-d-glucoside, ferulic acid and premarrubiin. Obtained data demonstrated that the investigated extract was richer in phenol (26.8 ± 0.01 mg/GAE g) than in flavonoids (0.61 ± 0.05 mg EC/mL). In addition, the methanolic extract showed an important antioxidant capacity against the DPPH (IC50 = 35 ± 0.01 µg/mL) and ABTS (IC50 = 25 ± 0.2 µg/mL) radical scavenging and a strong inhibition of acetylcholinesterase enzyme with an IC50 value corresponding to 0.4 mg/mL. The antibacterial activity demonstrated that the evaluated extract had significant activity against both Gram-positive and Gram-negative bacteria. The effect of time on cell integrity on E. coli and L. monocytogenes determined by time–kill and bacteriolysis tests showed that the M. vulgare extract reduced the viability of both strains after 8 and 10 h and had a bacteriolytic effect against two different categories of bacteria, Gram-positive and negative, which are not of the same potency. Based on obtained data, it can be concluded that Saudi M. vulgare has a high pharmacological importance and can be used in preparation of food or drugs.
Prehabilitation for Bariatric Surgery: A Randomized, Controlled Trial Protocol and Pilot Study
Authors: García-Delgado Yaiza , López-Madrazo-Hernández María José , Alvarado-Martel Dácil , Miranda-Calderín Guillermo , Ugarte-Lopetegui Arantza , González-Medina Raúl Alberto , Hernández-Lázaro Alba , Zamora Garlene , Pérez-Martín Nuria , Sánchez-Hernández Rosa María , Ibarra-González Adriana , Bengoa-Dolón Mónica , Mendoza-Vega Carmen Teresa , Appelvik-González Svein Mikael , Caballero-Díaz Yurena , Hernández-Hernández Juan Ramón , Wägner Ana María
Published: August 2021

Bariatric surgery is the most efficacious treatment for obesity, though it is not free from complications. Preoperative conditioning has proved beneficial in various clinical contexts, but the evidence is scarce on the role of prehabilitation in bariatric surgery. We describe the protocol and pilot study of a randomized (ratio 1:1), parallel, controlled trial assessing the effect of a physical conditioning and respiratory muscle training programme, added to a standard 8-week group intervention based on therapeutical education and cognitive-behavioural therapy, in patients awaiting bariatric surgery. The primary outcome is preoperative weight-loss. Secondary outcomes include associated comorbidity, eating behaviour, physical activity, quality of life, and short-term postoperative complications. A pilot sample of 15 participants has been randomized to the intervention or control groups and their baseline features and results are described. Only 5 patients completed the group programme and returned for assessment. Measures to improve adherence will be implemented and once the COVID-19 pandemic allows, the clinical trial will start. This is the first randomized, clinical trial assessing the effect of physical and respiratory prehabilitation, added to standard group education and cognitive-behavioural intervention in obese patients on the waiting list for bariatric surgery. Clinical Trial Registration: NCT0404636.