bluuebunny/crossref_metadata_2025 huggingface dataset:
KONTESTASI PANDANGAN BUDAYA DALAM SEJARAH KONGRES KEBUDAYAAN DI INDONESIA
Authors: Hendi Roy
Published: September 2021

Penelitian ini bertujuan untuk menjelaskan bagaimana kontestasi pandangan budaya yang terjadi pada peristiwa Kongres Kebudayaan Indonesia Tahun 1991. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kepustakaan dan teknik analisis kebudayaan dalam teks. Teks juga akan dianalisis dengan teori sosiologi kebudayaan menurut Raymond Williams untuk melihat proses produksi dan reproduksi budaya dalam teks. 

Peneliti menggunakan sebelas teks dari total delapan puluh sembilan teks. Studi ini menyimpulkan bahwa kontestasi pandangan dapat dilihat berdasarkan tiga karakteristik, yaitu terkait wacana pembangunan nasional, modernisasi kebudayaan Indonesia, dan peran kebudayaan dalam sektor kehidupan masyarakat. Hubungan antara kongres dan politik kebudayaan nasional ditunjukkan dengan adanya gagasan yang mendukung diskursus budaya Orde Baru dan mengkritiknya. 

Kongres Kebudayaan Indonesia Tahun 1991 melegitimasi politik kebudayaan nasional Orde Baru berdasarkan peran Direktorat Kebudayaan dan TMII, penafsiran atas formasi sosial masyarakat yang terbelakang, dan mode produksi dengan sistem kapitalisme. Sebagai sebuah tradisi yang dilakukan dalam setiap sejarah perkembangan budaya, kongres senantiasa mereproduksi nilai demokratisasi kebudayaan. Gagasan yang melegitimasi politik kebudayaan nasional Orde Baru dicontohkan melalui makalah kebudayaan Barnabas Suebu, Wayan Geriya, Soemitro, Tilaar, dan Sutan Takdir. Sedangkan, yang mengkritik atau menolak gagasan tersebut adalah Nirwan Dewanto, W.S. Rendra, Y.B. Mangunwijaya, Umar Kayam, Dawam Rahardjo, dan Arief Budiman. 

Kata Kunci: kebudayaan, kongres kebudayaan, orde baru, analisis teks, politik kebudayaan nasional.
Analisis Kelayakan Pemberian Kredit UKM pada BPR Artha Panggung Perkasa di Trenggalek
Authors: Lestari Novi Puji , Jihadi Muhammad , Fahruddin Achmad
Published: September 2021

Banking is a financial institution that exists in Indonesia which has an important role for the sustainability of the Indonesian economy. Economic growth must be directed at increasing people's incomes and overcoming economic inequality with social inequality. Economic growth in order to increase people's income, needs to be given attention to efforts to foster and protect small and traditional businesses and weak economic groups. Credit distribution is an important part of helping the economy and this is one of the tasks of the BPR. The Case Study conducted at BPR Panggung Perkasa Trenggalek, moreover their focus is on Small and Medium Enterprises. Credit distribution needs to be developed by providing loans to productive sectors, namely Small and Medium Enterprises.
Retracted notice to ‘‘Analisis Kepuasan Konsumen di Jatiroso Catering Service’’[JBMP (Jurnal Bisnis, Manajemen dan Perbankan), [S.l.], v. 1, n. 2, p. 102-120]
Authors: Arianto Mukhamad , Mahmudah Nur
Published: September 2021

This article was retracted at the request of the authors due to developments in the reported case.

 

Retracted article: https://doi.org/10.21070/jbmp.v1i2.267

Retracted notice: https://doi.org/10.21070/jbmp.v5i1.2066
Rancang Bangun Alat Pengering Pelepah Pisang(Menggunakan Metode Controller Chien Regulator I dan Chien Servo I Sebagai Tuning Kontrol PI)
Authors: Irianto Irianto , Suhariningsih Suhariningsih , Dewanti Viviana Ratna
Published: September 2021

Bananas provide many health benefits because they have enough vitamin A for daily body vitamins. Benefits of bananas are not only found in the fruit alone. Banana stem is rarely used because it is considered not to have more benefits and is only considered as waste. However, banana stem can be transformed into various forms of beautiful crafts and high economic value. Banana banana is dried first before being processed into various handicrafts. The process of drying banana is very dependent on the weather conditions and the heat of the sun. Conventional banana drying process takes approximately 70 hours with a solar temperature of about 40oC. The solution to this problem is, design and manufacture a microcontroller based banana bum dryer using PI control to regulate the temperature and utilize the heater as an alternative heat source. This PI control uses Chien Regulator I and Chien Servo I tuning methods. In this Final Project, temperature and banana moisture content is measured. The control will adjust the exhaust fan when the temperature read by LM35 is displayed on LCD 4x20 for temperature monitoring. To adjust the AC-AC voltage controller voltage on the heater, depending on the angle of ignition of the TCA785 IC. DAC of Microcontroller ATMega16 will convert the digital data released microcontroller into analog voltage. The Kp and Ki values used are Kp = 5 and Ki 0.625 using Chien Regulator I method and Kp = 4,126 and Ki 0.414 using Chien Servo I method The drying process takes 16 hours with water content of 4.76% at ± 65oC using Chien Servo I method because the temperature response is more stable.
Implementasi Labview Untuk Pemantauan Pemakaian Energi Listrik
Authors: Yunus Muhammad Yusuf , Marhatang Marhatang
Published: September 2021

In conventional electric measurement devices, measurements are made on the use of electrical energy as a whole where consumers can only see information on the results of the use of electrical energy by looking at the total power consumption amount indicated on the meter kWh meter. Based on the above problems, the author aims to raise the title "Design of Monitoring System of Electricity Energy Usage using LabVIEW". The LabVIEW program has the ability to measure, monitor and store data quickly and accurately. With this tool will be realized a design system monitoring the use of electrical energy in real time through the computer instead of kWH meter analog or digital. This concept is one of the energy management solutions that enable consumers to obtain statistical data on electrical energy consumption in detail. From the results of monitoring the use of loads, obtained very good results in monitoring the usage of energy, which in this case using household burden.
Environmental Controls on the Distribution of Modern Benthic Foraminifera in the Florida Everglades and Their Use as Paleoenvironmental Indicators
Authors: Verlaak Zoë R. F. , Collins Laurel S.
Published: September 2021

This study examined the environmental factors that control the distribution of modern foraminiferal assemblages in the Everglades in order to provide baseline data for a paleoenvironmental study. Total assemblages from the surface 2 cm of 30 sites across the marsh and mangrove environments of southwest Florida were investigated. Eight environmental variables, including average salinity, salinity range, pH, total phosphorus, temperature, and dissolved oxygen, and total organic carbon and total inorganic carbon measured on bulk sediments, as well as the elevation and distance from the coastline were determined for each of the 30 sampling locations.

In total, 82 species were identified, the majority of which were calcareous. Diversity decreases, dominance increases, and agglutinated taxa increase from the coastline inland. Rotaliina are equally abundant across the intertidal environment, whereas Miliolina are common near the coast and in lagoons or inland lakes. The most important factor controlling foraminiferal distribution is total organic carbon, followed by total inorganic carbon, distance from coastline, total phosphorus, and salinity. Jadammina macrescens and Miliammina fusca indicate lower salinities (<15 psu). Good indicators for higher salinities are Haplophragmoides wilberti (10–20 psu) and Arenoparrella mexicana (10–20 psu and 28–30 psu). Ammonia spp. prefer salinities >15 psu and Elphidium spp. >20 psu. Ammonia tepida, Helenina anderseni, Trochammina inflata, and A. mexicana prefer organic-rich sediments. Thus, the benthic foraminifera from Everglades sediments are excellent salinity proxies and can be used to determine the history of habitat change in this area as well as to assess past trends in the rate of sea level rise.
SUCESSÃO FAMILIAR EMPROPRIEDADES RURAIS FAMILIARES NO MUNICÍPIO DE LONDRINA-PR
Authors: Diamor Stella de Souza , Sudré Carolina Andrea Gomez Winkler
Published: September 2021

O objetivo do presente estudo é compreender como se dá o processo sucessório na produção rural familiar na região de Londrina – PR. Para tanto, a partir de estudos sobre sucessão familiar e sucessão rural familiar, foi realizada uma pesquisa qualitativa com entrevistas semiestruturadas com agricultores da região. Os dados foram analisados pela análise de conteúdo qualitativa, e como principal resultado observou-se que faltam discussão e planejamento da sucessão rural familiar na região. As principais dificuldades enfrentadas pelos agricultores são os altos custos, baixo retorno, clima, dificuldade de acesso às estradas e distância da escola e de hospitais, que podem influenciar de forma negativa na sucessão. As facilidades são a tranquilidade do campo, amor a profissão, autonomia e tecnologias que podem influenciar de forma positiva na sucessão. Além disso, faltam programas dos influenciadores, cooperativas e Estado, para amparar os produtores, e discutir sobre o tema e valorizar o jovem agricultor.
Usage of Compromised Lung Volume in Monitoring Steroid Therapy on Severe COVID-19
Authors: Su Ying , Qiu Ze-song , Chen Jun , Ju Min-jie , Ma Guo-guang , He Jin-wei , Yu Shen-ji , Liu Kai , Lure Fleming Y. M. , Tu Guo-wei , Zhang Yu-yao , Luo Zhe
Published: September 2021

BackgroundQuantitative computed tomography (QCT) analysis may serve as a tool for assessing the severity of coronavirus disease 2019 (COVID-19)and for monitoringits progress. The present study aimed to assess the association between steroid therapy and quantitative CT parameters in a longitudinal cohort with COVID-19.MethodsBetween February 7 and February 17, 2020, 300 chest CT scans from 72 patients with severe COVID-19 were retrospectively collected and classified into five stages according to the interval between hospital admission and follow-up CT scans: Stage 1 (at admission); Stage 2 (3–7 days); Stage 3 (8–14 days); Stage 4 (15–21 days); and Stage 5 (22–31 days). QCT was performed using a threshold-based quantitative analysis to segment the lungaccording to different Hounsfield unit (HU) intervals. The primary outcomeswerechanges in percentage of compromised lung volume (%CL, –500 to 100 HU) at different stages. Multivariate Generalized Estimating Equations were performed after adjusting for potential confounders.ResultsOf 72 patients, 31 patients (43.1%) received steroid therapy. Steroid therapy was associated with a decrease in %CL (-3.27% [95%CI, -5.86 to -0.68,P = 0.01]) after adjusting for duration and baseline %CL. Associations between steroid therapy and changes in %CL varied between different stages or baseline %CL (all interactions,P<0.01). Steroid therapy was associated with decrease in %CL after stage 3 (all P<0.05), but not at stage 2. Similarly, steroid therapy was associated with a more significant decrease in %CL in the high CL group (P<0.05), but not inthe low CL group.ConclusionsSteroid administration was independently associated with a decrease in %CL, with interaction by duration or disease severity in a longitudinal cohort. The quantitative CT parameters, particularly compromised lung volume, may provide a useful tool to monitor COVID-19 progression during the treatment process. Trial registration: Clinicaltrials.gov, NCT04953247. Registered July 7, 2021, https://clinicaltrials.gov/ct2/show/NCT04953247
The Baseline Serum Uric Acid as an Indicator of Chemotherapy-Related Adverse Reaction and Mortality in Aged Males with Stage IIIB or IV Non-Small Cell Lung Cancer
Authors: Chen Xiaoyan , Hou Lisha , Li Jianqun , Shen Yanjiao , Tan Fucha , Dong Birong , Hao Qiukui
Published: September 2021

Objective: To evaluate the accuracy of baselineserum uric acid(BSUA) in estimating adverse effects (AE) and all-cause mortality (ACM) in older males with stage IIIB or IV non-small cell lung cancer (NSCLC) diagnosis.Study design:This is a single-center retrospective examination, conducted at the West China Hospital, Sichuan University in Chengdu, Sichuan Province, China, between the duration of January 2010 and December 2017.Primary outcome and measures:: All patients data was obtained based on medical reports and mortality information was gathered via telephone interviews. BUSA was assessed prior to chemotherapy. Additionally, the end points of this study included chemotherapy-mediated AE and ACM. Binarylogistic regression analysis was used to explore the correlation between BSUA and AE. Lastly, Cox regression analysis was utilized to examine theimpactof BSUA on ACM.Results: 317 male patients with NSCLC were eligible for this study. Within this population, 18.3% had stage IIIB and 81.7% had stage IV NSCLC. Moreover, 81.39% suffered from adenocarcinoma lung cancer (ACLC), whereas 18.61% suffered from squamous cell carcinoma lung cancer (SCCLC). As of March 1, 2019, 257 (81.07%) patients expired. Following the initial chemotherapeutic course, short-term AE like bone marrow suppression, all infection, liver dysfunction, and digestive reactions, wereobserved in 13.25%, 7.26%, 5.36%, and 4.1% of cases, respectively. Upon normalizing with confounding factors, the adjustedlogistic regression model demonstrated thatthe moderate BSUA was independently linked to a lower risk of bone marrow suppression (OR=0.407,95% CI:0.178-0.931; p=0.033).Moreover, based on the Cox regression analysis, moderate BSUAwas also independently correlated with a low mortality risk (HR=0.705,95% CI:0.518-0.959; p=0.026).Conclusion：In males patients withstage IIIB or IV NSCLC, BSUA is intimately linked to chemotherapy-driven AE and ACM.
Effect of Eccentric and Concentric Contraction Mode on Myogenic Regulatory Factors Expression in Human Vastus Lateralis Muscle
Authors: Sabouri Mostafa , Taghibeikzadehbadr Pejman , Shabkhiz Fatemeh , Izanloo Zahra , Shaghaghi Farahnaz Amir
Published: September 2021

Background: Skeletal muscle contractions are caused to release myokines by muscle fiber. This study investigated the myogenic regulatory factors, as MHC I, IIA, IIX, Myo-D, MRF4, Murf, Atrogin-1, Decorin, Myonection, and IL-15 mRNA expression in the response of eccentric vs. concentric contraction. Methods: Eighteen healthy men were randomly divided into two eccentric and concentric groups, each of 9 persons. Isokinetic contraction protocols included maximal single-leg eccentric or concentric knee extension tasks at 60°/s with the dominant leg. Contractions consisted of a maximum of 12 sets of 10 reps, and the rest time between each set was 30 seconds. The baseline biopsy was performed four weeks before the study, and post-test biopsies were taken immediately after exercise protocols from Vastus Lateralis muscle. The gene expression levels evaluated using Real-Time PCR methods. Results: A significant difference in MyoD, MRF4, Myonection, and Decorin mRNA, were observed following eccentric or concentric contractions (P≤0.05). The MHC I, MHC IIA, IL-15 mRNA has been changed significantly compared to the pre-exercise in the concentric group (P≤0.05). While only MHC IIX and Atrogin-1 mRNA changed significantly in the eccentric group (P≤0.05). Additionally, the results showed a significant difference in MyoD, MRF4, IL-15, and Decorin were observed at the follow-up values between eccentric or concentric groups (P≤0.05). Conclusion: Our findings highlight the growing importance of elucidating the different responses of muscle growth factors associated with a myogenic activity such as MHC IIA, Decorin, IL-15, Myonectin, Decorin, MuRF1, and MHC IIX mRNA in following to various types of exercise.
A Novel Ferroptosis-related Gene Signature for Prognosis Prediction in Glioma
Authors: Lan Tian , Wu Die , Quan Wei , Yu Donghu , Li Sheng , Yao Jie , Li Zhi-Qiang
Published: September 2021

Background: Glioma is a fatal brain tumor characterized by invasive nature, rapidly proliferation and tumor recurrence. Despite aggressive surgical resection followed by concurrent radiotherapy and chemotherapy, the overall survival (OS) of Glioma patients remains poor. Ferroptosis is a unique modality to regulate programmed cell death and associated with multiple steps of tumorigenesis of a variety of tumors.Methods: In this study, ferroptosis-related genes model was identified by differential analysis and Cox regression analysis. GO, KEGG and GSVA analysis were used to detect the potential biological functions and signaling pathway. The infiltration of immune cells was quantified by Cibersort.Results: The patients’ samples are stratified into two risk groups based on 4-gene signature. High-risk group has poorer overall survival. The results of functional analysis indicated that the extracellular matrix-related biologic functions and pathways were enriched in high-risk group, and that the infiltration of immunocytes is different in two groups.Conclusion: In summary, a novel ferroptosis-related gene signature can be used for prognostic prediction in glioma. The filtered genes related to ferroptosis in clinical could be a potential extra method to assess glioma patients’ prognosis and therapeutic.
Simple And Green Synthesis of Calcium Alginate/Hydroxyapatite Hybrid Material Without High Temperature Treatment And Its Flame Retardancy
Authors: Huang Qiying , Xue Hanjing , Dong Ruitao , Xue Yun , Zhou Xiaodong , Li Zichao , Li Qun
Published: September 2021

Aiming to improve the thermal stability and flame retardant properties of calcium alginate, calcium alginate (CaAlg)/hydroxyapatite (HAP) hybrid material was synthesized in situ by the sol-gel method at room temperature. It was found that the HAP particles were generated from nanospheres to urchin-like microspheres, finally to wrinkled sponge microspheres with the two-dimensional nanostructured surface. The results show that the thermal stability and flame retardancy of the hybrid material were significantly improved, and its mechanism was proposed as HAP promoted the decarboxylation of alginate resulting in carbonization of CaAlg/HAP, and it was the function of soild phase before 350 ℃, while the synergistic effects of gas phase and solid phase after 350 ℃ that led to the high flame retardancy of CaAlg/HAP.
Experimental Study of the Quantification of Indocyanine Green Fluorescence in Ischemic and Non-Ischemic Anastomoses, Using the Sergreen Software Program
Authors: Serra-Aracil Xavier , García-Nalda Albert , Serra-Gomez Borja , Serra-Gomez Alvaro , Mora-Lopez Laura , Pallisera-Lloveras Anna , Lucas-Guerrero Victoria , Navarro-Soto Salvador
Published: September 2021

Background: Tissue ischemia is a key risk factor for anastomotic leakage (AL). Indocyanine green (ICG) is widely used in colorectal surgery to define the segments with the best vascularization. In an experimental model, we present a new system for quantifying ICG saturation, SERGREEN software.Methods: This was a controlled experimental study with eight pigs. In the initial control stage, ICG saturation was analyzed at the level of two anastomoses in the right and left colon. Control images of the two segments were taken after ICG administration. The images were processed with the SERGREEN program. Then, in the experimental ischemia stage, the inferior mesenteric artery was sectioned at the level of the anastomosis of the left colon. Fifteen minutes after the section, sequential images of the two anastomoses were taken every 30’ for the following 2 h.Results: At the control stage, the mean scores were 134.2 (95% CI: 116.3-152.2) for the right colon and 147 (95% CI: 134.7-159.3) for the left colon (p = 0.174). The right colon remained stable throughout the experiment. In the left colon, saturation fell by 47.9 points with respect to the preischemia value (p <0.01). After the first postischemia determination, the values of the ischemic left colon remained stable throughout the experiment. The relative decrease in ICG saturation of the ischemic left colon was 32.6%.Conclusions: The SERGREEN program quantifies ICG saturation in normal and ischemic situations and detects differences between them. A reduction in ICG saturation of 32.6% or more was correlated with complete tissue ischemia.
Boron Induced Crystallization of Silicon Oon Glass: An Alternate Way to Crystallize Amorphous Silicon Films for Solar Cells
Authors: JUNEJA SUCHETA , kumar sushil
Published: September 2021

Demand for efficient window layer in thin film solar cells with high crystallinity is ever increasing that finds important application in multi-junction/tandem silicon solar cells. Doping of diborane (B2H6) in hydrogenated silicon films using plasma discharge decomposition of silane (SiH4) and (B2H6) gases were analyzed. The boron flow (FB) to silane ratio was varied from 0–0.30. Variation in film characteristics with B2H6 gas-phase ratio were analyzed, and concluded that doping boron induces crystallization in hydrogenated amorphous silicon (a-Si: H) film structure. The Raman and field emission scanning electron spectroscopy (FESEM) confirmed the boron induced crystallinity effect in silicon films at different diborane flow. The results showed that as boron content increases beyond certain ratio, silicon crystallization suppresses and the crystallite sizes were also reduced. From results, it was observed that crystallinity in FB = 0.05 is 79 % and decreases to 77 % when films are slightly higher doped (FB = 0.10) and further decreases when the films were heavily doped. These results validate that boron suppresses silicon crystallization due to local deformations caused by the impurities. Infra-red absorption studies and their analysis also confirm the crystallization in boron doped films with additional band appears at ~ 611 cm− 1. This band is named as boron induced crystallinity mode of vibrational spectra. The estimated hydrogen content (CH) decreases confirmed crystallinity in the silicon structure with boron doping. Further, the energy dispersive spectroscopy (EDX) indicates the presence of boron and other impurities in deposited silicon films. The effect of boron on crystallinity and crystallite size as well as the mechanism were presented in detailed.
Viral Co-pathogens in COVID-19 Acute Respiratory Syndrome – What Did We Learn From the First Year of Pandemic?
Authors: Kriger Or , Gefen-Halevi Shiraz , Leshem Eyal , Smollan Gillian , Belausov Natasha , Egbarye Aseel , Khashab Rawan , Odeh Miran , Saffia Adleen , Barak Yuval , Hussein Oswa Abu , Hamias Rachel , Aharon Yael , Alfandari Jacqueline , Nemet Ital , Kliker Limor , Sherbany Hilda , Mandelboim Michal , Amit Sharon
Published: September 2021

We assessed the annual occurrence and diversity of respiratory pathogens in SARS-CoV-2 positive and negative patients admitted due to acute respiratory illness (ARI). A multiplex-PCR panel targeting 23 microorganisms detected other respiratory pathogens in only 8/476 (2%) COVID-19 versus 87/463 (19%) non-COVID-19 ARI patients. Diversity and rates of pathogens vastly differed from previous years yet showed seasonal variance.
Enrichment and verification of differentially expressed miRNAs in the ovarian tissue of Leizhou black ducks
Authors: Lu Lili , Asiamah Collins Amponsah , Liu yuanbo , Ye Rungen , Pan Yiting , Jiang Ping , Su Ying , Zhao Zhihui
Published: September 2021

Background

Ovary is an important reproductive organ for poultry. MicroRNA (miRNA) is a highly conserved class of small non-coding RNA that function in a specific manner to post-transcriptionally regulate gene expression in organisms. Currently, miRNA has been studied extensively but research on duck ovarian tissue is relatively rare. Thus, in this study, we performed the first miRNA analysis of ovarian tissues in Leizhou black ducks with low and high rates of egg production.
Method:

Using high-throughput sequencing technology, miRNA library was constructed to obtain miRNA expression profile; differentially expressed miRNAs were screened, to predict miRNA target genes.
Results

A total of 29 differentially expressed miRNAs were obtained from the miRNA library, of which 7 were up-regulated and 22 were down-regulated. Verification of 12 randomly selected miRNAs, using RT-qPCR technology showed the results are consistent with the sequencing data, indicating that the sequencing results are reliable. The GO enrichment and KEGG pathway enrichment analysis of differential miRNAs showed that target genes were significantly enriched in signal pathways related to ovarian development, such as the oxytocin signaling pathway, GnRH signaling pathway, progesterone-mediated oocyte maturation, and AMPK signal pathway.
Conclusion

The research results enrich the data resources of duck miRNAs, and provide a theoretical basis for further research on the laying performance of poultry and molecular-assisted breeding of poultry in the future.
Establishment of Base Interactions of Select Genus Between Multiple Chick Sources in Differential Housing
Authors: Chasteen Kaicie S , Brooks Lasheda , Munoz Luis , Krehling James , Bailey Matthew , Macklin Kenneth S
Published: September 2021

BackgroundMicrobial communities in the gut are influenced and shaped by both an individual’s interactions with their environment and the interactions of their progenitors. In chickens, this includes the hatchery they originated from, as well as the environment in which the egg was laid. This study aimed to establish the extent to which the microbial communities of source hatcheries influenced the microbiome of broilers over time by placing birds from two separate source hatcheries (HA,HB) in to both a floor pen and battery cage system as three distinct populations HA, HB, and mixed population (MP). MP was made up of half HA individuals and half HB individuals. Samples of the midgut (defined as the area between the duodenal loop and Meckel’s diverticulum) and the ceca were taken at day 0, 5, and 14 for battery cage birds, and day 0,5,14, 16, 21, 28, and 48 for floor raised birds.ResultsBirds from HA and HB both displayed distinct microbial communities in day 0 samples and retained some of these characteristics through day 48. Furthermore MP samples seemed to be influenced more by the microbiome of the source hatchery that displayed a higher number of OTUs at day zero. More diverse day 0 microbiomes also seemed more resistant to larger shifts in community composition as time progressed. There is some indication that parental diet also shaped the microbiomes of the broiler chickens, with the genus Bacteroides appearing in HB (parent stock fed non-vegetarian diet) populations as early as day 5, MP day 14, and finally appearing in HA (parent stock feed vegetarian diet) at day 21.ConclusionsThe results suggest that there may be a net positive effect on the microbiome of a flock by placing birds with strong day 0 microbial communities in a mixed flock with those with weak or non-beneficial microbial communities.
Long-term Health Effects of Antipyretic Drug Use in the Ageing Population: A Systematic Review
Authors: Mahesh Seema , Werf Esther van der , Mallappa Mahesh , Vithoulkas George , Lai Nai Ming
Published: September 2021

Background: It is unclear whether fever suppression is beneficial or harmful in the long term in the elderly, due to different immune profile and body temperature compared to the young. Our objective was to determine the long-term health effects of antipyretic treatment in the elderly during infections.Methods: A systematic review was carried out using PubMed, Embase and Cochrane CENTRAL databases. Studies with a sample age ≥60 years investigating any antipyretic drug during infections, comparing with any other drug/therapy/placebo/none were included. Studies in which these drugs were used in roles other than antipyresis were excluded. Databases were searched from their inception until the date of last analysis (27/03/2021). Primary outcome was the onset or worsening of chronic inflammatory diseases. Secondary outcomes were fever reduction, length of hospital stay, patient satisfaction, mortality, laboratory parameters indicative of morbidity, and progress to complications. The Risk of Bias (ROB) was assessed for each study type with the respective ROB formats– Cochrane’s ROB tool for RCTs, ROBINS-I tool for observational studies, Joanna Brigg’s critical appraisal tool for case series and the Cochrane handbook prescribed domains for case reports. Narrative synthesis was performed because high heterogeneity rendered meta-analysis impossible.Results: Of 11481, 17 studies (2 RCTs, 7 observational, 1 case series and 7 case reports) were included. No studies investigated the primary outcome and patient-reported outcomes.The Risk-of-bias of the studies was unclear to high. Fever reduction was significant in the RCTs, in the antipyretic group. BP drop was significant in five studies, in the antipyretic group. Morbidity indicators and length of stay were available only in studies that reported adverse events. Mortality was significant for these drugs in one observational study. The certainty of evidence (GRADE) was low to very low for all outcomes, including fever reduction and mortality. Discussion/Conclusions: There is insufficient evidence regarding the long-term benefit or harm from fever suppression with antipyretics during infections in the elderly. Systematic review registration: This study was funded by the Taylor’s University Ageing Flagship Program and the protocol was registered on PROSPERO (registration number: CRD42020160854)
DDX10 Promotes the Proliferation and Metastasis of Colorectal Cancer Cells via Splicing RPL35
Authors: Zhou Xin , Liu Zhihong , Zhang Cuifeng , Jiang Manman , Jin Yuxiao , Wu Ziyu , Gu Changji , Zhang Wei , Yang Xiaodong
Published: September 2021

Background: Colorectal cancer (CRC) has become the second deadliest cancer in the world and severely threatens human health. An increasing number of studies have focused on the role of the RNA helicase DEAD-box (DDX) family in CRC. However, the mechanism of DDX10 in CRC has not been elucidated.Methods: In our study, we analysed the expression data of CRC samples from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Subsequently, we performed cytological experiments and animal experiments to explore the role of DDX10 in CRC cells. Furthermore, we performed Gene Ontology (GO)/ Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and protein-protein interaction (PPI) network analyses. Finally, we predicted the interacting protein of DDX10 by LC-MS/MS and verified it by coimmunoprecipitation (Co-IP) and qPCR.Results: In the present study, we identified that DDX10 mRNA was extremely highly expressed in CRC tissues compared with normal colon tissues in the TCGA and GEO databases. The protein expression of DDX10 was measured by immunochemistry (IHC) in 17 CRC patients. The biological roles of DDX10 were explored via cell and molecular biology experiments in vitro and in vivo and cell cycle assays. We found that DDX10 knockdown markedly reduced CRC cell proliferation, migration and invasion. Then, we constructed a PPI network with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING). GO and KEGG enrichment analysis and gene set enrichment analysis (GSEA) showed that DDX10 was closely related to RNA splicing and E2F targets. Using LC-MS/MS and Co-IP assays, we discovered that RPL35 is the interacting protein of DDX10. In addition, we hypothesize that RPL35 is related to the E2F pathway and the immune response in CRC.Conclusions: In conclusion, provides a better understanding of the molecular mechanisms of DDX10 in CRC and provides a potential biomarker for the diagnosis and treatment of CRC.
Staphylococcus Aureus Isolates From Eurasian Beavers (Castor Fiber) Carry a Novel Phage-borne Bicomponent Leukocidin Related to the Panton-valentine Leukocidin
Authors: Monecke Stefan , Feßler Andrea T. , Burgold-Voigt Sindy , Krüger Henrike , Mühldorfer Kristin , Wibbelt Gudrun , Liebler-Tenorio Elisabeth M. , Reinicke Martin , Braun Sascha D. , Hanke Dennis , Diezel Celia , Müller Elke , Loncaric Igor , Schwarz Stefan , Ehricht Ralf
Published: September 2021

Staphylococcus aureus can be a harmless coloniser, but it can also cause severe infections in humans, livestock and wildlife. Regarding the latter, only few studies have been performed and knowledge on virulence factors is insufficient. The aim of the present study was to study S. aureus isolates from deceased wild beavers (Castor fiber). Seventeen isolates from eleven beavers, found in Germany and Austria, were investigated. Antimicrobial and biocide susceptibility tests were performed. Isolates were characterised using S. aureus-specific DNA microarrays, spa typing and whole-genome sequencing. From two isolates, prophages were induced by Mitomycin C and studied by transmission electron microscopy.Four isolates belonged to clonal complex (CC) 8, CC12, and CC398. Twelve isolates belonged to CC1956 and one isolate was CC49. The CC49 and CC1956 isolates carried distinct lukF/S genes related to the Panton-Valentine leukocidin (PVL) from human isolates of S. aureus. These genes were located on related, but not identical, Siphovirus prophages. The beavers, from which those isolates originated, suffered from abscesses, purulent organ lesions and necrotising pneumonia, i.e., clinical manifestations resembling symptoms of severe PVL-associated disease in humans. It might thus be assumed that the “Beaver Leukocidin (BVL, lukF/S-BV)”-positive strains are beaver-specific pathogens, and further studies on their clinical role as well as on a possible transmissibility to other species, including humans, are warranted.
Comparative Study of Synthesis Parameters of Nanoporous Titania Particles to Improve Structural Properties and Photocatalytic Activity
Authors: Hassankhani-Majd Zahra , Anbia Mansoor
Published: September 2021

Nanoporous materials have been widely used in many fields. However, their synthesis with uniform particle shapes, pore sizes, pore volumes, and surface areas remains a considerable challenge. Thus, choosing a suitable controllable method for synthesizing nanoporous materials is crucial to obtain appropriate properties. Herein, nanoporous titania particles (NPTPs) were prepared via the hydrothermal. This study investigated how the synthesis parameters such as the type of chelating agent, the hydrolysis method, and the drying technique affected the properties of NPTPs. The synthesis NPTPs were characterized by XRD, FESEM, and BET. The results demonstrated that when acetylacetone (ACAC) (as the chelating agent), the spray-hydrolysis (SH) method, and the freeze-drying (FD) technique were used, NPTPs achieved a more uniform particle shape, a smaller particle size, a larger pore size, a larger pore volume, and a higher surface area. Ultimately, the photocatalytic degradation (PCD) of methylene blue (MB) was examined using improved NPTPs.
Attenuation of Alloxan-induced Low-grade Inflammation by Persea Americana Polyphenolic Peel Extract in Male Wistar Rats
Authors: oluba OLAREWAJU MICHAEL , Abasiri Daniel O. , Ibitoye Babatunde , Ojeaburu Samuel , Eidangbe George , Akinduko Ayokunmi , Alabi Olayinka
Published: September 2021

Background: Based on the conceived causal relationship that exist between oxidative stress, hyperglycemia and low‐grade inflammation, this study was hypothesized to evaluate how treatment with polyphenolic peel extract of avocado pear (APPE), with established antioxidant activity, may be deployed in the management of complications arising from diabetes. Methods: Twenty adult male alloxan-induced diabetic Wistar rats randomly assigned to five groups (n = 5) designated: diabetic control (DC), treated with distilled water; and 25, 50, 100 and 200 mg/kg APPE, respectively. A sixth group comprising of five normal rats administered distilled water served as normal control (NC). Results: Following a 21-day single daily oral administration of APPE, remarkable improvements in body weight and blood glucose concentration were noted in diabetic rats especially at 200 mg/kg compared to DC. A dose-related significant reductions in glycated hemoglobin, interleukins (1β and 6), tumour necrosis factor-α (TNF-α) levels in diabetic rats treated with APPE compared to DC. Conversely, serum insulin and interleukin-10 concentrations were significantly elevated in a dose-related fashion in APPE administered diabetic rats compared to DC. Unlike the intestine and heart which were spared severe morphological treatment due to alloxan intoxication, diabetic control rat and those on low dose of the extract showed varying degree of interface hepatitis and glomerulosclerosis. However, diabetic rats on 200 mg/kg APPE were protected from the damaging effects of diabetes mellitus on the liver and kidney.Conclusion: APPE abrogated the oxidative stress-induced hepatic and nephrotic damage in diabetic rats.
An effective model for quantification of cell 3Dshape in early embryogenesis
Authors: Li Zelin , Cao Jianfeng , Zhao Zhongying , Yan Hong
Published: September 2021

Background: The developmental process is featured by fabulous morphogenesis in multicellular organisms. Describing morphological changes quantitatively concretes the way to investigating both intra and inter cell regulations on cell fate. While Caenorhabditis elegans has been used as a model for cell and development studies for a long time, the exploration of how cell shape is precisely controlled keeps obscured by the lack of methods to model morphological features. Currently, in order to characterize the features of cell shape involved in cell migration and differentiation, there is an increasing demand in analyzing cell shape systematically, especially when many works have contributed to cell reconstruction.
Results: In this work, Spherical harmonics and Principal component analysis integrated Cell Shape quantification Models (SPCSMs) is proposed to represent cell shapes in a low-dimensional shape space. SPCSMs incorporates a complete pipeline to quantify cell shapes and analyze their morphological phenotypes in three dimensional (3D) reconstructions. Based on the framework, we extract biological patterns in the lineage of C. elegans embryo before 350-cell stage, during which all hypodermis cells deformed like a funnel and can be recognized by this shape pattern. Finally, SPCSMs is compared with two cell shape representation methods, which substantiates the effectiveness and robustness of our method.
Conclusion: SPCSMs provides a general method to decribe shapes in low-dimensional shape space with compact parameters. It can quantify the shapes of cells from single-cell resolution images obtained over one-minute intervals, making it possible for the recognition of developmental patterns in cell lineages. SPCSMs is expected to be an effective model for biologists to explore the relationships between the shapes of cells and their fates.
Important Role of SDF-1/CXCR4 Axis in the Homing of Systemically Transplanted Human Amnion-Derived Mesenchymal Stem Cells (Had-Mscs) to Ovaries in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency (POI)
Authors: Ling Li , Hou Jiying , Liu Dandan , Tang Dongyuan , Zhang Yanqin , Zeng Qianru , Pan Heng , Fan Ling
Published: September 2021

Background: Chemotherapy can induce premature ovarian insufficiency (POI). POI causes multiple sequelae and is currently incurable. Our previous studies have demonstrated that systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) can home to chemotherapy-induced POI ovaries, and thus reduce ovarian injury and improve ovarian function in rats with POI. However, the cellular mechanisms that direct the migration and homing of hAD-MSCs to chemotherapy-induced POI ovaries are barely understood. This study was to investigate the role of SDF-1/CXCR4 axis in the migration and homing of systemically transplanted hAD-MSCs to chemotherapy-induced POI ovaries and its relevant downstream signaling pathways.Methods: CXCR4 expression in hAD-MSCs was tested by western blot and immunofluorescence assay. hAD-MSC migration was tested by transwell migration assay. SDF-1 level in rats was detected by ELISA. 72 of female SD rats were randomly divided into the control, POI, hAD-MSCs and hAD-MSCs+AMD3100 groups. POI rat models were established by intraperitoneal injection of cyclophosphamide. For the inhibitor treatment, hAD-MSCs were pretreated with AMD3100 before transplantation. hAD-MSCs labeled with PKH26 were injected into the tail vein of POI rats at 24 h after chemotherapy. After hAD-MSC transplantation, the homing of hAD-MSCs in ovaries, and ovarian function and pathological changes were examined. To further investigate molecular mechanisms, PI3K/Akt and ERK1/2 signaling pathways were detected. Results: hAD-MSCs expressed CXCR4. SDF-1 induced hAD-MSC migration in vitro. SDF-1 levels in ovaries and serum significantly increased in POI rats induced by chemotherapy, and POI ovaries attracted the homing of hAD-MSCs expressing CXCR4. The block of SDF-1/CXCR4 axis with AMD3100 can significantly reduce the number of hAD-MSCs homing to the POI ovaries, and further reduce their efficacy in POI treatment. The binding of SDF-1 to CXCR4 activated PI3K/Akt signaling pathway, and LY294002 significantly inhibited hAD-MSC migration induced by SDF-1 in vitro. Moreover, inhibition of PI3K/Akt signaling pathway significantly reduced the number of systemically transplanted hAD-MSCs homing to chemotherapy-induced POI ovaries in rats.Conclusions: SDF-1/CXCR4 axis partially mediates the migration and homing of systemically transplanted hAD-MSCs to chemotherapy-induced POI ovaries in rats, and PI3K/Akt signaling pathway might be involved in the migration and homing of hAD-MSCs mediated by SDF-1/CXCR4 axis.
Cellulose Nanocrystals Obtained From Microcrystalline Cellulose by p-toluene Sulfonic Acid Hydrolysis, NaOH and Ethylenediamine Treatment
Authors: Wang Songlin , Wang Qian , Kai Yao
Published: September 2021

Cellulose nanocrystals (CNC) were first isolated from microcrystalline cellulose (MCC) by p-toluene sulfonic acid (p-TsOH) hydrolysis. Cellulose II nanocrystal (CNC II) and cellulose III nanocrystal (CNC III) were then formed by swelling the obtained cellulose I nanocrystal (CNC I) in concentrated sodium hydroxide solutions and ethylenediamine (EDA) respectively. The properties of CNC I, CNC II and CNC III were subjected to comprehensive characterization by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). The results indicated that CNC I, CNC II and CNC III obtained in this research had high crystallinity index and good thermal stability. The degradation temperatures of the resulted CNC I, CNC II and CNC III were 300 ℃, 275 ℃ and 242 ℃, respectively. No ester bonds were found in the resulted CNC. CNC prepared in this research also had large aspect ratio and high negative zeta potential.
Approach to an automatic prediction of the state of industrial manipulators using machine learning methods
Authors:   National Research Tomsk Polytechnic University (NI TPU), Goncharov A. S. , Savelev A. O. ,   National Research Tomsk Polytechnic University (NI TPU), Pisankin A. S. ,   National Research Tomsk Polytechnic University (NI TPU), Chepkasov A. Y. ,   National Research Tomsk Polytechnic University (NI TPU), Jayakody D. N. K. ,   National Research Tomsk Polytechnic University (NI TPU)
Published: September 2021

Due to intensive development of information technologies and the onset of 4th industrial revolution the number of robotic industries is steadily growing. The volume of production and the use of robots is also increasing. At the same time, the support and the management of digital production is being rapidly developing. The robotic systems are incapable of completely excluding a person from the technological chain, since they need timely maintenance and personnel working out the emergency situations. One of the solutions to reduce the risk of unexpected breakdowns is a predictive approach to the maintenance. The implementation of this approach is carried out using data analysis tools. This study presents the results of applying machine learning methods to analyze data from industrial robots in order to predict potential failures
Hardware solutions for energy-efficient control technologies of distribution network objects based on power semiconductor devices
Authors:   PKF Modern Technologies LLC, Krysanov V. N. , Burkovskii V. L. ,   Voronezh State Technical University, Khaychenko I. A. ,   Voronezh State Technical University
Published: September 2021

The article considers topical issues in development of energysaving technologies to optimize the control of distribution networks according to the criterion of minimum power losses. The technology consists in introducing new hardware to control the modes based on static devices. Based on the analysis of the existing hardware created to control the modes of distributio networks, the developed circuitry solutions of the power part and the control system of the multifunctional thyristor voltage transformer and hybrid thyristor capacitor are proposed. Their main technical characteristics and ways to reduce voltage asymmetry, limiting short circuit currents and regulating reactive power are det ermined. The use of software and hardware solutions was recommended for a wide range of energy conservation tasks, both in the electric power sector and at the level of industrial facilities
Análise das temáticas publicadas pela Revista de Epidemiologia e Controle de Infecção
Authors: Joaquim Cassiandra sampaio , Nunes Ezequiel Servegnini , Orfão Nathalia Halax , Valim Andreia Rosane de Moura , Possuelo Lia Gonçalves
Published: September 2021

A fim de reconhecer as temáticas mais publicadas, entre 2011 a 2021, pela Revista de Epidemiologia e Controle de Infecção (RECI) realizou-se um estudo descritivo retrospectivo a partir de um levantamento e posterior análise de diversos assuntos com manuscritos já veiculados no periódico, com ênfase para o campo de doenças. Os resultados evidenciam que a maioria das publicações possuíam como temática a tuberculose (15%), seguida das doenças crônicas não transmissíveis (13%) e zoonoses (10%). Observa-se que tais dados são necessários para identificar quais temáticas predominam, direcionando o enfoque do periódico, além de aperfeiçoá-lo e de definir estratégias, tais como chamadas para publicações especiais.
Crossref Funder Registry
Authors: Damasio Edilson
Published: September 2021

O Crossref Funder Registry é uma metodologia de organização de IDs de financiadores/agências de financiamento. Assim, é necessária sua utilização através de depósito de metadados junto ao Crossref, padronizados, com informações sobre o financiador e subsídio. Faz parte do processo de editoração científica e deve ser utilizado com mais frequência. No Brasil e em outros países a adoção de medatados de financiamento ainda é pequena. Visa mostrar a importância do Funder Registry e seus objetivos visando principalmente informar os financiadores.