bluuebunny/crossref_metadata_2025 huggingface dataset:
Getting On in Gotham: The Midtown Manhattan Study and Putting the “Social” in Psychiatry
Authors: Smith Matthew
Published: September 2021

In the spring of 1962, a series of alarming headlines greeted American newspaper readers. From “New York Living for Nuts Only” and “One in Five Here Mentally Fit” to “Scratch a New Yorker, and What Do You Find?” and “City Gets Mental Test, Results are Real Crazy,” the stories highlighted the shocking and, to some, incredible statistics that fewer than one in five (18.5%) Manhattanites had good mental health. Approximately a quarter of them had such bad mental health that they were effectively incapacitated, often unable to work or function socially. The headlines were gleaned fromMental Health in the Metropolis(1962), the first major output of the Midtown Manhattan Study, a large-scale, interdisciplinary project that surveyed the mental health of 1660 white Upper East Side residents between the ages of 20 and 59. One of the most significant social psychiatry projects to emerge following the Second World War, the Midtown Manhattan Study endeavored to “test the general hypothesis that biosocial and sociocultural factors leave imprints on mental health which are discernible when viewed from the panoramic perspective provided by a large population.” Despite initial media and academic interest, however, the Midtown Manhattan Study’s findings were soon forgotten, as American psychiatry turned its focus to individual—rather than population—psychopathology, and turned to the brain—rather than the environment—for explanations. Relying on archival sources, contemporary medical and social scientific literature, and oral history interviews, this article explains why the Midtown Manhattan Study failed to become more influential, concluding that its emphasis on the role of social isolation and poverty in mental illness should be taken more seriously today.
Phenotype and pathological significance of MCAM+ (CD146+) T cell subset in psoriatic arthritis
Authors: Raychaudhuri Smriti K. , Abria Christine , Raychaudhuri Siba P.
Published: September 2021

Background

CD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146+IL-17+memory T cells in PsA synovium and studied the association of CD146 expression and CD4+IL-17+activated memory (CD11a+CD45RO+) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients.

Methods

Hi-D FACS studies were done to identify IL-17 in CD4+CD146+CD45RO+and CD8+CD146+CD45RO+T cells.

Results

We observed that effector CD146+(MCAM+) T cells are enriched at the synovial inflammation site in PsA.

Conclusion

As CD146+T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM+pathologic cells are critical for the disease process of PsA.
Construction of a Review About Epigenetics for Biology Teachers and Other Non-experts
Authors: Mc Ewen Birgitta
Published: September 2021

Epigenetics, the new research field at the cutting edge of biology research, needs to be introduced in biology education. The aim of this review is to support biology teachers and other non-experts to get an overview of the field, as a review in epigenetics has hardly been written for these groups. This review was done by finding documents describing central features of epigenetics, increasing the understanding of epigenetics’ contribution to perspectives in society, and to be a model for a review in a rapidly developing science field. As an example of societal perspectives, the old dispute about “nature” or “nurture” is discussed, epigenetics focusing on the role of “nurture’s” influence on “nature.” Consequently, epigenetics dispels biological determinism. As this review was intended to fill a gap in the literature, a theoretical framework for the construction of the review had to be invented. This was done in an iterative process during the construction of the review. Documents were searched for in the databases of ERIC, Scopus, and Web of Science, peer-reviewed, and had been published by a well-renowned publisher. The search time frame was January 2016 to December 2019, including document types books and book chapters, plus journal articles for ERIC; documents had to be written in English and published as open access. Searches were divided into pre-defined categories based on a newly performed Delphi study. Exemplar studies, which best described each category, are discussed in the light of frontline research. As implications from epigenetics are important for a variety of areas within society, the review is a contribution to the field of sociology of science, aiming to support science education at the very front of science.
Motion Magnification in Solar Imaging Data Sequences in the Sub-pixel Regime
Authors: Zhong Sihui , Duckenfield Timothy J. , Nakariakov Valery M. , Anfinogentov Sergey A.
Published: September 2021

The capability of the motion-magnification technique for the detection of transverse oscillations, such as kink oscillations of solar coronal loops observed with an imaging telescope, in the sub-pixel regime is investigated. The technique is applied to artificial-image sequences imitating harmonic transverse displacements of the loop, observed in the optically thin regime. Motion magnification is found to work well on the analysis of sub-pixel, $\geq 0.01$
≥
0.01
 pixel oscillations, and it is characterised by linear scaling between the magnified amplitude and input amplitude. Oscillations of loops with transverse density profiles of different steepness are considered. After magnification, the original transverse profiles are preserved sufficiently well. The motion-magnification performance is found to be robust in noisy data, for coloured noise with spectral indices ranging from 0 to 3, and additional Poisson noise with a signal-to-background-noise ratio down to unity. Our findings confirm the reliability of the motion-magnification technique for applications in magnetohydrodynamic seismology of the solar corona.
Microplastic Contamination in Protected Areas of the Gulf of Venice
Authors: Mistri Michele , Scoponi Marco , Sfriso Andrea A. , Munari Cristina , Curiotto Marta , Sfriso Adriano , Orlando-Bonaca Martina , Lipej Lovrenc
Published: September 2021

We investigated the concentration and composition of plastics in 7 Special Areas of Conservation (SACs) from the Gulf of Venice (northern Adriatic Sea). A total of 42 sediment samples were analyzed from 21 sites from 2017 to 2018. All sites except one were found to be polluted by plastics, with density ranging between 2250 and 28.4 items kg−1. Microplastics ranged from 100 to 61.6% of the collected plastics. Fragments were more represented than filaments. The greatest plastic concentrations were generally recorded in western SACs. Identification through FT-IR spectroscopy evidenced the presence of 8 polymer types: in western SACS, the majority were low-density polymers (PE, PP, PS, and TPU), while in eastern SACs they were high-density polymers (PET, nylon, and PVC). In addition to the role of large rivers (all on the western side of the Gulf) in conveying plastics into the sea, a possible role of the cyclonic water circulation of the northern Adriatic Sea on distribution and composition of plastics along the Gulf coasts is likely.
Removal of fluoride from coke wastewater by aluminum doped chelating ion-exchange resins: a tertiary treatment
Authors: Rodríguez-Iglesias Jesús , Alcalá Lara , Megido Laura , Castrillón Leonor
Published: September 2021

Coke wastewater is one of the most problematic industrial wastewaters, due to its large volume and complex pollutant load. In this study, ion exchange technology was investigated with the objective of reducing the fluoride content of the effluent from a coke wastewater treatment plant (26.7 mg F-/L). Two Al-doped exchange resins with chelating aminomethyl-phosphonic acid and iminodiacetic groups were assessed: Al-doped TP260 and TP207 resins, respectively. The effect of resin dosage, varying from 5 to 25 g/L, was evaluated. F- removal was within the range 57.8–89.3% and 72.0–92.1% for Al-doped TP260 and TP207, respectively. A kinetic study based on a generalized integrated Langmuir kinetic equation fitted the experimental data (R2 > 0.98). The parameters of the said kinetics met the optimal conditions for the ion exchange process, which seemed to be more favorable with Al-doped TP260 resin than with Al-doped TP207 resin, using the same resin dosage. Furthermore, the experimental data were well described (R2 > 0.98) by Langmuir and Freundlich isotherm models, in agreement with the findings of the kinetic study: the maximum sorption capacity was obtained for the Al-doped TP260 resin.
The Effect of Building Direction on Microstructure and Microhardness during Selective Laser Melting of Ti6Al4V Titanium Alloy
Authors: Palmeri D. , Buffa G. , Pollara G. , Fratini L.
Published: September 2021

During the last few years, additive manufacturing has been more and more extensively used in several industries, especially in the aerospace and medical device fields, to produce Ti6Al4V titanium alloy parts. During the Selective Laser Melting (SLM) process, the heterogeneity of finished product is strictly connected to the scan strategies and the building direction. An optimal managing of the latter parameters allows to better control and defines the final mechanical and metallurgical properties of parts. Acting on the building direction it is also possible to optimize the critical support structure. In particular, more support structures are needed for the sample at 0°, while very low support are required for the sample at 90°. To study the effects of build direction on microstructure heterogeneity evolution and mechanical performances of selective laser melted Ti6Al4V parts, two build direction samples (0°, 90°) were manufactured and analyzed using optical metallographic microscope (OM) and scanning electron microscopy (SEM). Isometric microstructure reconstruction and microhardness tests were carried out in order to analyze the specimens. The obtained results indicate that the build direction has to be considered a key geometrical parameter affecting the overall quality of the obtained products.
Optimization of geometric parameters of soil nailing using response surface methodology
Authors: Benayoun Fadila , Boumezerane Djamalddine , Bekkouche Souhila Rehab , Ismail Fadhel
Published: September 2021

Optimization of parameters of soil nailing is an important task in reinforcement soil problems. This paper focuses on the effect of nail geometric parameters on soil nailed wall analysis and identifies which factors that most affect their stability and cost using response surface methodology (RSM). RSM has been chosen to achieve an optimum combination of the soil nailing wall design. The influence of three factors has been considered; it included nail length, its inclination, and vertical spacing between nails. After a finite element analysis to model and perform the soil nailing simulations, a Box–Behnken design was applied, based on a set of experiments using various combinations. For this purpose, 15 runs were conducted to analyze tested parameters and to determine their interactions. The analysis of variance (ANOVA) and contour lines plots were investigated, and therefore, the most important parameters affecting the safety factor and the cost were identified. From the goodness-of-fit analyses of the model and the illustrative example, the proposed regression model provides a reasonably good estimate of the overall safety factor for soil nail walls and their cost. The results obtained from this study showed that RSM is an efficient and effective tool to identify the optimal combination, and it emerges that the safety factor and cost are most influenced by nail length and vertical spacing.
Ten Instructional Design Efforts to Help Behavior Analysts Take Up the Torch of Direct Instruction
Authors: Spencer Trina D.
Published: September 2021

Although behavior analysts are trained in discrete trial instruction, other instructional approaches like Direct Instruction are underutilized in behavior analytic practice. Direct Instruction is a specialized technology that capitalizes on sophisticated instructional design and highly effective delivery strategies. What makes Direct Instruction so powerful is that it emphasizes the development of generative repertoires and establishes them efficiently. The purpose of this article is to introduce 10 critical instructional design efforts that behavior analysts can use in their practice, regardless of the population they serve and repertoires they build. The 10 instructional design efforts are summarized in a Direct Instruction Planning Guide. Behavior analysts can follow this sequence of design efforts and refer to the guiding questions as they develop efficient instruction for their learners. In doing so, behavior analysts can take up the torch of Direct Instruction, extend this remarkable instructional approach into their research and practice, and strengthen the behavioral technology available to behavior analytic practitioners.
I disordini endocrini nella pratica clinica: epidemiologia e domanda di salute nella vita reale
Authors: Crafa Andrea , Calogero Aldo E. , Condorelli Rosita A. , Cannarella Rossella , La Vignera Sandro
Published: September 2021

Sommario

Le patologie del sistema endocrino hanno un notevole impatto dal punto di vista epidemiologico sulla salute delle popolazioni. Esse sono in grado di alterare la qualità della vita dei pazienti affetti e sono responsabili di disabilità a lungo termine; si collocano al quinto posto tra le cause di morte. In questa revisione della letteratura abbiamo valutato la prevalenza e l’incidenza delle principali malattie endocrine nel mondo e in Italia per evidenziarne il reale impatto nella pratica clinica dell’endocrinologo.
Cost Dynamics of Clean Energy Technologies
Authors: Glenk Gunther , Meier Rebecca , Reichelstein Stefan
Published: September 2021

The pace of the global decarbonization process is widely believed to hinge on the rate of cost improvements for clean energy technologies, in particular renewable power and energy storage. This paper adopts the classical learning-by-doing framework of Wright (1936), which predicts that cost will fall as a function of the cumulative volume of past deployments. We first examine the learning curves for solar photovoltaic modules, wind turbines and electrolyzers. These estimates then become the basis for estimating the dynamics of the life-cycle cost of generating the corresponding clean energy, i.e., electricity from solar and wind power as well as hydrogen. Our calculations point to significant and sustained learning curves, which, in some contexts, predict a much more rapid cost decline than suggested by the traditional 80% learning curve. Finally, we argue that the observed learning curves for individual clean energy technologies reinforce each other in advancing the transition to a decarbonized energy economy.
Fast and exact audit scheduling optimization
Authors: Motl Jan , Kordík Pavel
Published: September 2021

This article is concerned with the cost and time-effective scheduling of financial auditors with integer linear programming. The schedule optimization considers 13 different constraints, staff scarcity, frequent alterations of the input data with the need to minimize the changes in the generated schedule, and scaling issues. The delivered implementation reduced the time to the first schedule from 3 man-days to 1 h and the schedule update time from 1 man-day to 4 min.
Estimation of the Ephemerides and Gravity Fields of the Galilean Moons Through Orbit Determination of the JUICE Mission
Authors: Magnanini Andrea
Published: September 2021

Jupiter and its moons are a complex dynamical system that include several phenomena like tides interactions, moon’s librations and resonances. One of the most interesting characteristics of the Jovian system is the presence of the Laplace resonance, where the orbital periods of Ganymede, Europa and Io maintain a 4:2:1 ratio, respectively. It is interesting to study the role of the Laplace resonance in the dynamic of the system, especially regarding the dissipative nature of the tidal interaction between Jupiter and its closest moon, Io. The secular orbital evolution of the Galilean satellites, and so the Laplace resonance, is strongly influenced by the tidal interaction between Jupiter and its moons, especially with Io. Numerous theories have been proposed regarding this topic, but they disagree about the amount of dissipation of the system, therefore about the magnitude and the direction of the evolution of the system, mainly because of the lack of experimental data. The future ESA JUICE space mission is a great opportunity to solve this dispute. The data that will be collect during the mission will have an exceptional accuracy, allowing to investigate several aspects of the dynamics the system and possibly the evolution of Laplace Resonance of the Galilean moons. This work will focus on the gravity estimation and orbit reconstruction of the Galilean satellites by precise orbit determination of the JUICE mission during the Jovian orbital phase using radiometric data.
Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells
Authors: Hsiao Hao-Wen , Yang Chi-Chun , Masai Hisao
Published: September 2021

Human cells need to cope with the stalling of DNA replication to complete replication of the entire genome to minimize genome instability. They respond to “replication stress” by activating the conserved ATR-Claspin-Chk1 replication checkpoint pathway. The stalled replication fork is detected and stabilized by the checkpoint proteins to prevent disintegration of the replication fork, to remove the lesion or problems that are causing fork block, and to facilitate the continuation of fork progression. Claspin, a factor conserved from yeasts to human, plays a crucial role as a mediator that transmits the replication fork arrest signal from the sensor kinase, ataxia telangiectasia and Rad3-related (ATR), to the effector kinase, Checkpoint kinase 1 (Chk1). Claspin interacts with multiple kinases and replication factors and facilitates efficient replication fork progression and initiation during the normal course of DNA replication as well. It interacts with Cdc7 kinase through the acidic patch segment near the C-terminus and this interaction is critical for efficient phosphorylation of Mcm in non-cancer cells and also for checkpoint activation. Phosphorylation of Claspin by Cdc7, recruited to the acidic patch, regulates the conformation of Claspin through affecting the intramolecular interaction between the N- and C-terminal segments of Claspin. Abundance of Claspin is regulated at both mRNA and protein levels (post-transcriptional regulation and protein stability) and affects the extent of replication checkpoint. In this article, we will discuss how the ATR-Claspin-Chk1 regulates normal and stressed DNA replication and provide insight into the therapeutic potential of targeting replication checkpoint for efficient cancer cell death.
Adjoint-based aerodynamic drag minimisation with trim penalty
Authors: Shitrit S.
Published: September 2021

The aerodynamic performance of conventional aircraft configurations are mainly affected by the wing and horizontal tail. Drag reduction by shape optimisation of the wing, while taking into account the aircraft trimmed constraint, has more benefit than focusing solely on the wing. So in order to evaluate this approach, the following study presents results of a single and multipoint aerodynamic shape optimisation of the wing-body-tail configuration, defined by the Aerodynamic Design Discussion Group (ADODG). Most of the aerodynamic shape optimisation problems published in the last years are focused mainly on the wing as the main driver for performance improvement, with no trim constraint and/or excess drag obtained from the fuselage, fins or other parts. This work partially fills this gap by an investigation of RANS-based aerodynamic optimisation for transonic trimmed flight. Mesh warping and geometry parametrisation is accomplished by fitting the multi-block structured grid to a B-spline volumes and performing the mesh movement by using surface control points embedded within the free-form deformation (FFD) volumes. A gradient-based optimisation algorithm is used with an adjoint method in order to compute the derivatives of the objective and constraint functions with respect to the design variables. In this work the aerodynamic shape optimisation of the CRM wing-body-tail configuration is investigated, including a trim constraint that is satisfied by rotating the horizontal tail. The shape optimisation is driven by 432 design variables that envelope the wing surface, and 120 shape variables for the tail, as well as the angle of attack and tail rotation angles. The constraints are the lift coefficient, wing’s thickness controlled by 1,000 control points, and the wing’s volume. For the untrimmed configuration the drag coefficient is reduced by 5.76%. Optimising the wing with a trim condition by tail rotation results in shock-free design with a considerably improved drag, even better than the untrimmed-optimised case. The second optimisation problem studied is a single and multi-point lift constraint drag minimisation of a gliding configuration wing in transonic viscous flow. The shock is eliminated, reducing the drag of the untrimmed configuration by more than 60%, using 192 design variables. Further robustness is achieved through a multi-point optimisation with more than 45% drag reduction.
Transition to chaos in a two-sided collapsible channel flow
Authors: Huang Qiuxiang , Tian Fang-Bao , Young John , Lai Joseph C.S.
Published: September 2021

The nonlinear dynamics of a two-sided collapsible channel flow is investigated by using an immersed boundary-lattice Boltzmann method. The stability of the hydrodynamic flow and collapsible channel walls is examined over a wide range of Reynolds numbers

$Re$

, structure-to-fluid mass ratios

$M$

and external pressures

$P_e$

. Based on extensive simulations, we first characterise the chaotic behaviours of the collapsible channel flow and explore possible routes to chaos. We then explore the physical mechanisms responsible for the onset of self-excited oscillations. Nonlinear and rich dynamic behaviours of the collapsible system are discovered. Specifically, the system experiences a supercritical Hopf bifurcation leading to a period-1 limit cycle oscillation. The existence of chaotic behaviours of the collapsible channel walls is confirmed by a positive dominant Lyapunov exponent and a chaotic attractor in the velocity-displacement phase portrait of the mid-point of the collapsible channel wall. Chaos in the system can be reached via period-doubling and quasi-periodic bifurcations. It is also found that symmetry breaking is not a prerequisite for the onset of self-excited oscillations. However, symmetry breaking induced by mass ratio and external pressure may lead to a chaotic state. Unbalanced transmural pressure, wall inertia and shear layer instabilities in the vorticity waves contribute to the onset of self-excited oscillations of the collapsible system. The period-doubling, quasi-periodic and chaotic oscillations are closely associated with vortex pairing and merging of adjacent vortices, and interactions between the vortices on the upper and lower walls downstream of the throat.
Rigid centres on the center manifold of tridimensional differential systems
Authors: Mahdi Adam , Pessoa Claudio , Ribeiro Jarne D.
Published: September 2021

Motivated by the definition of rigid centres for planar differential systems, we introduce the study of rigid centres on the center manifolds of differential systems on $\mathbb {R}^{3}$. On the plane, these centres have been extensively studied and several interesting results have been obtained. We present results that characterize the rigid systems on $\mathbb {R}^{3}$ and solve the centre-focus problem for several families of rigid systems.
Carbon sequestration: counterintuitive feedback of plant growth
Authors: Alonso-Serra Juan
Published: September 2021

Interaction between the atmosphere, plants and soils plays an important role in the carbon cycle. Soils contain vast amounts of carbon, but their capacity to keep it belowground depends on the long-term ecosystem dynamics. Plant growth has the potential of adding or releasing carbon from soil stocks. Since plant growth is also stimulated by higher CO2 levels, understanding its impact on soils becomes crucial for estimating carbon sequestration at the ecosystem level. A recent meta-analysis explored the effect CO2 levels have in plant versus soil carbon sequestration. The integration of 108 experiments performed across different environments revealed that the magnitude of plant growth and the nutrient acquisition strategy result in counterintuitive feedback for soil carbon sequestration.
Novel dual-fluorescent flow cytometric approach for quantification of macrophages infected with Leishmania infantum parasites
Authors: Islek Zeynep , Ucisik Mehmet Hikmet , Sahin Fikrettin
Published: September 2021

Flow cytometry analysis emerges as an alternative methodology to microscopy for determination of the Leishmania-infection rates of macrophages. Various flow cytometric approaches have been established for the quantification of Leishmania parasites within host cells, labelled either directly fluorescent dyes or indirectly with fluorescently conjugated antibodies. Although these techniques allow accurate quantification of infection, they fail at detection of non-infected macrophages specifically. This study introduces a new flow cytometric approach for the determination of infection rates of macrophages infected by Leishmania infantum parasites. Prior to infection, J774A.1 macrophages and L. infantum promastigotes were stained separately with PKH26 and PKH67 dyes, respectively. Dual staining enabled detection of each cell type, where non-infected macrophages were also recorded for the quantification. Dual-PKH staining achieved high success in selective staining of promastigotes (99.71%) and macrophages (99.57%). The percentages of parasite-infected macrophages were determined for initial 1:2.5 and 1:10 infection ratios as 15.68 and 61.70%, respectively; indicating significant increase in infection rate parallel to the initial treatment ratio. These results demonstrated that the introduced dual-fluorescence flow cytometric approach can be successfully used as an accurate and rapid quantification method for L. infantum-infected macrophages and strengthens the hypothesis that flow cytometric approaches could replace conventional microscopic methodologies.
Life expectancy, mortality risks and cause of death in patients with serious mental illness in South East London: a comparison between 2008–2012 and 2013–2017
Authors: Chang Chi-Kang , Chesney Edward , Teng Wei-Nung , Hollandt Sam , Pritchard Megan , Shetty Hitesh , Stewart Robert , McGuire Philip , Patel Rashmi
Published: September 2021

Background

People with serious mental illness (SMI) have a significantly shorter life expectancy than the general population. This study investigates whether the mortality rate in this group has changed over the last decade.

Methods

Using Clinical Record Interactive Search software, we extracted data from a large electronic database of patients in South East London. All patients with schizophrenia, schizoaffective disorder or bipolar disorder from 2008 to 2012 and/or 2013 to 2017 were included. Estimates of life expectancy at birth, standardised mortality ratios and causes of death were obtained for each cohort according to diagnosis and gender. Comparisons were made between cohorts and with the general population using data obtained from the UK Office of National Statistics.

Results

In total, 26 005 patients were included. In men, life expectancy was greater in 2013–2017 (64.9 years; 95% CI 63.6–66.3) than in 2008–2012 (63.2 years; 95% CI 61.5–64.9). Similarly, in women, life expectancy was greater in 2013–2017 (69.1 years; 95% CI 67.5–70.7) than in 2008–2012 (68.1 years; 95% CI 66.2–69.9). The difference with general population life expectancy fell by 0.9 years between cohorts in men, and 0.5 years in women. In the 2013–2017 cohorts, cancer accounted for a similar proportion of deaths as cardiovascular disease.

Conclusions

Relative to the general population, life expectancy for people with SMI is still much worse, though it appears to be improving. The increased cancer-related mortality suggests that physical health monitoring should consider including cancer as well.
Self-processing in relation to emotion and reward processing in depression
Authors: Hobbs Catherine , Sui Jie , Kessler David , Munafò Marcus R. , Button Katherine S.
Published: September 2021

Background

Depression is characterised by a heightened self-focus, which is believed to be associated with differences in emotion and reward processing. However, the precise relationship between these cognitive domains is not well understood. We examined the role of self-reference in emotion and reward processing, separately and in combination, in relation to depression.

Methods

Adults experiencing varying levels of depression (n = 144) completed self-report depression measures (PHQ-9, BDI-II). We measured self, emotion and reward processing, separately and in combination, using three cognitive tasks.

Results

When self-processing was measured independently of emotion and reward, in a simple associative learning task, there was little association with depression. However, when self and emotion processing occurred in combination in a self-esteem go/no-go task, depression was associated with an increased positive other bias [b = 3.51, 95% confidence interval (CI) 1.24–5.79]. When the self was processed in relation to emotion and reward, in a social evaluation learning task, depression was associated with reduced positive self-biases (b = 0.11, 95% CI 0.05–0.17).

Conclusions

Depression was associated with enhanced positive implicit associations with others, and reduced positive learning about the self, culminating in reduced self-favouring biases. However, when self, emotion and reward processing occurred independently there was little evidence of an association with depression. Treatments targeting reduced positive self-biases may provide more sensitive targets for therapeutic intervention and potential biomarkers of treatment responses, allowing the development of more effective interventions.
Equatorial aberration for powder diffraction data collected by continuous-scan integration of a silicon strip X-ray detector
Authors: Ida Takashi
Published: September 2021

The application of continuous-scan integration to collect X-ray diffraction data with a Si strip X-ray detector (CSI-SSXD) introduces additional effects on the peak shift and deformation of peak shape caused by the equatorial aberration. A deconvolutional method to correct the effects of equatorial aberration in CSI-SSXD data is proposed in this study. There are four critical angles related to the effects of spillover of the incident X-ray beam from the specimen face in the CSI-SSXD data. Exact values of cumulants of the equatorial aberration function are efficiently evaluated by 4 × 4 point two-dimensional Gauss–Legendre integral. A naïve two-step deconvolutional method has been applied to remove the effects of the first and third-order cumulants of the equatorial aberration function from the observed CSI-SSXD data. The performance of the algorithm has been tested by analyses of CSI-SSXD data of three LaB6 powder specimens with the widths of 20, 10, and 5 mm, collected with a diffractometer with the goniometer radius of 150 mm.
‘International Shanghai’ (1863–1931): Imperialism and private authority in the Global City
Authors: Cong Wanshu , Mégret Frédéric
Published: September 2021

At the intersection of imperial rule and private power, Shanghai rose to international prominence in the second half of the nineteenth and first half of the twentieth century. It did so by taking advantage of the extraterritorial status and the dynamic, cosmopolitan population of the International Settlement. In evaluating the fate of the Shanghai Municipal Council, we seek to ascertain how private authority could have been constituted on a transnational basis within the framework of a treaty port. The rise of Shanghai was linked to some of the ambiguities of overlapping imperial rule and the possibilities it created for legal and governance experimentation. This is particularly clear in realms most associated with sovereign power, namely the International Settlement’s attempts to claim some taxation power and maintain law and order. That power, however, was interstitial at best and the product of fragile balances, as shown by the Council’s ultimate failure to secure a full international legal status for Shanghai. Nonetheless, the rise and fall of the International Settlement at Shanghai are worth reflecting upon, not only in relation to the history of China, imperialism and international law, but also as a way of thinking how the authority of large metropolitan centres might be constituted.
Retour surLes sons du français:la modernité de Passy
Authors: Durand Jacques , Lyche Chantal
Published: September 2021

Au sein de l’enseignement de l’oral, il est souvent difficile de convaincre les didacticiens du français qu’un recours à la phonologie et à la phonétique faisant place à la variation et la diversité des usages est possible et souhaitable. Pourtant, dès la fin du 19èmesiècle, une autre pratique était défendue par des jeunes phonéticiens dont Paul Passy, auteur desSons du français(1887) et coordinateur de la mise en place de l’API. Passy, à cause de ses engagements socio-politiques et religieux, de sa défense souvent mal comprise de l’API et de son combat pour la réforme de l’orthographe, est fréquemment relégué à une place relativement mineure dans l’histoire de la phonétique du français. Nous démontrons ici que les nombreuses révisions desSons du françaisfourmillent de descriptions fines et de remarques sur des changements en cours qui, dans bien des cas, seront redécouverts dans la deuxième partie du 20èmesiècle sans mention de son travail. Nous abordons alors la question de la norme et l’attachement de Passy à la variation et montrons sa modernité à travers son traitement de la prosodie, des unités distinctives, des réalisations allophoniques et de la transcription phonétique.
FREEDOM FROM THINGS: A DEFENSE OF THE DISJUNCTIVE OBLIGATION IN CONTRACT LAW
Authors: Nadler Jennifer
Published: September 2021

This article argues that the disjunctive obligation in contract law can be justified on moral grounds. It argues that from a perspective that regards human beings as free agents capable of choice and therefore independent of material objects, the contracting parties must be understood as agreeing to mutually guarantee one another's ownership of a certain value. This guarantee can be fulfilled either by handing over what was promised or by making up the difference between the market value and the contract value of what was promised. The plaintiff's contractual right is therefore a right that the defendant perform or pay. This makes expectation damages intelligible as a vindication of the plaintiff's contractual right. Moreover, the disjunctive obligation can be reconciled with all the doctrines that others take to be decisive arguments against it—with the doctrines of specific performance, inducing breach, impossibility, preexisting duty consideration, and nominal damages.
The contribution of cognitive behavioural factors to social anxiety in Parkinson’s disease
Authors: Nash Kirsty , Dysch Leon , Todd Jones Jenna , MacQueen Ruth , Marks Elizabeth
Published: September 2021

Background:

Social anxiety is prevalent in idiopathic Parkinson’s disease but why this is, is not yet well understood. Social cognitions, safety-seeking behaviours and internally focused attention are all known to predict social anxiety in the general population. These associated factors have not yet been explored in idiopathic Parkinson’s disease, where disease severity and motor symptoms might also influence the experience of social anxiety.

Aims:

This study aimed to explore the relationship between cognitive behavioural factors and social anxiety in Parkinson’s disease.

Method:

Using a cross-sectional design, 124 people with Parkinson’s disease completed self-report questionnaires including measures of Parkinson’s disease severity, social anxiety, negative social cognitions, safety-seeking behaviours, internally focused attention, anxiety and depression.

Results:

The final regression model accounted for 71.6% of variance in social anxiety. Cognitive behavioural variables accounted for the largest magnitude of unique variance (43.5%). Sex, anxiety and depression accounted for 23.4%, and Parkinson non-motor symptom severity for 4.7%. Negative social cognitions and safety-seeking behaviours were statistically significant predictors, while an internal focus of attention was not.

Conclusions:

Social anxiety in Parkinson’s disease is associated with negative social cognitions and safety-seeking behaviours. Findings indicate the need for further research into cognitive behavioural approaches to social anxiety in Parkinson’s disease.
The Phase Transformations Induced by High-Pressure Torsion in Ti–Nb-Based Alloys
Authors: Korneva Anna , Straumal Boris , Kilmametov Askar , Lityńska-Dobrzyńska Lidia , Chulist Robert , Gondek Łukasz , Zięba Paweł
Published: September 2021

The study of the fundamentals of the α → ω and β → ω phase transformations induced by high-pressure torsion (HPT) in Ti–Nb-based alloys is presented in the current work. Prior to HPT, three alloys with 5, 10, and 20 wt% of Nb were annealed in the temperature range of 700–540°C in order to obtain the (α + β)-phase state with a different amount of the β-phase. The samples were annealed for a long time in order to reach equilibrium Nb content in the α-solid solution. Scanning electron microscope (SEM), transmission electron microscopy, and X-ray diffraction techniques were used for the characterization of the microstructure evolution and phase transformations. HPT results in a strong grain refinement of the microstructure, a partial transformation of the α-phase into the ω-phase, and a complete β → ω phase transformation. Two kinds of the ω-phase with different chemical compositions were observed after HPT. The first one was formed from the β-phase, enriched in Nb, and the second one from the almost Nb-pure α-phase. It was found that the α → ω phase transformation depends on the Nb content in the initial α-Ti phase. The less the amount of Nb in the α-phase, the more the amount of the α-phase is transformed into the ω-phase.
Atom Probe Study of 1-Octadecanethiol Self-Assembled Monolayers on Platinum (111) and (200) Surfaces
Authors: Solodenko Helena , Stender Patrick , Schmitz Guido
Published: September 2021

Atom probe tomography measurements of self-assembled monolayers of 1-octadecanethiol on platinum tips were performed and their fragmentation behavior under the influence of different laser powers was investigated. The carbon backbone evaporates in the form of small hydrocarbon fragments consisting of one to four carbon atoms, while sulfur evaporates exclusively as single ions. The carbon molecules evaporate at very low fields of 5.9 V/nm, while S requires a considerably higher evaporation field of 23.4 V/nm. With increasing laser power, a weak, but noticeable trend toward larger fragment sizes is observed. No hydrocarbon fragments containing S are detected, indicating that a strong S–Pt bond has formed. The observed surface coverage of S fits well with literature values and is higher for (111)-oriented samples than for (200).
FURTHER DEFENSE OF THE RACIALIZATION CONCEPT
Authors: Hochman Adam
Published: September 2021

In my article, Racialization: A Defense of the Concept, I argue that ‘race’ fails as an analytic category and that we should think in terms of ‘racialization’ and ‘racialized groups’ instead. I define these concepts and defend them against a range of criticisms. In Rethinking Racialization: The Analytical Limits of Racialization, Deniz Uyan critiques my “theory of racialization”. However, I do not defend a theory of racialization; I defend the concept of racialization. I argue that racialization is a useful idea, but I do not advance a theory to explain or predict the phenomena it describes. While Uyan’s critique therefore misses its mark, it raises important questions about the explanatory scope of the racialization concept. Ironically, I may be even more skeptical of the prospects of any general theory of racialization than Uyan. I argue that while we ought to develop theories to explain particular instances of racialization, we should not develop a general theory of racialization, because it is simply too varied in its agents and their intents, the mechanisms through which it operates, and the outcomes it produces. While hope for any general theory of racialisation should be abandoned, I argue that the racialisation concept is still extremely useful. It offers a necessary alternative to race realist concepts, allowing us to point to the wide-ranging effects of belief in race without falsely implying that race itself is real. Uyan does not focus on my arguments against racial realism. However, the theoretical failures and normative risks of racial realism motivate my defense of the racialization concept. In this paper, I reiterate my arguments against racial realism and offer further defense of the concepts of ‘racialization’ and ‘racialized group’.
Meeting Emotional Needs in Intellectual Disability: The Developmental Approach
Authors: Sappok Tanja , Zepperitz Sabine , Hudson Mark
Published: September 2021

Using a developmental perspective, the authors offer a new, integrated model for supporting people with intellectual disability (ID). This concept builds upon recent advances in attachment-informed approaches, by drawing upon a broader understanding of the social, emotional, and cognitive competencies of people with ID, which is grounded in developmental neuroscience and psychology. The book explores in detail how challenging behaviour and mental health difficulties in people with ID arise when their basic emotional needs are not being met by those in the environment. Using individually tailored interventions, which complement existing models of care, practitioners can help to facilitate maturational processes and reduce behavior that is challenging to others. As a result, the ‘fit’ of a person within his or her individual environment can be improved. Case examples throughout the book illuminate how this approach works by targeting interventions towards the person’s stage of emotional development. This book will be of interest to a wide range of professionals working with people with ID, including: clinical psychologists, psychiatrists, occupational therapists, learning disability nurses, speech and language therapists, and teachers in special education settings, as well as parents and caregivers.
Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons
Authors: Kelly Jamie M. , Ivatt Peter D. , Evans Mathew J. , Kroll Jesse H. , Hrdina Amy I. H. , Kohale Ishwar N. , White Forest M. , Engelward Bevin P. , Selin Noelle E.
Published: September 2021

In assessments of cancer risk from atmospheric polycyclic aromatic hydrocarbons (PAHs), scientists and regulators rarely consider the complex mixture of emitted compounds and degradation products, and they often represent the entire mixture using a single emitted compound—benzo[a]pyrene. Here, we show that benzo[a]pyrene is a poor indicator of PAH risk distribution and management: nearly 90% of cancer risk worldwide results from other PAHs, including unregulated degradation products of emitted PAHs. We develop and apply a global‐scale atmospheric model and conduct health impact analyses to estimate human cancer risk from 16 PAHs and several of their N‐PAH degradation products. We find that benzo[a]pyrene is a minor contributor to the total cancer risks of PAHs (11%); the remaining risk comes from other directly emitted PAHs (72%) and N‐PAHs (17%). We show that assessment and policy‐making that relies solely on benzo[a]pyrene exposure provides misleading estimates of risk distribution, the importance of chemical processes, and the prospects for risk mitigation. We conclude that researchers and decision‐makers should consider additional PAHs as well as degradation products.
Diversity in the Persistence of El Niño Events Over the Last Millennium
Authors: Sanchez Sara C. , Karnauskas Kristopher B.
Published: September 2021

The El Niño Southern Oscillation (ENSO) is a mode of internal climate variability with far‐reaching impacts. Here, we consider an important aspect of ENSO behavior: the diversity in the persistence of El Niño events. We examine the occurrence of multi‐year El Niño events in instrumental observations, a suite of global climate model simulations of the last millennium, and paleoclimate archives. We find evidence of multi‐year El Niño events in all data sources considered, with a wide range of variability in the frequency of such events across and within the individual sources. Although scarce over the relatively brief satellite era, multi‐year El Niño events are often associated with the warmest El Niño events in observations and most models. Furthermore, we show that multi‐year El Niño events augment the persistence of associated hydroclimate anomalies, which may compound the impacts on vulnerable economies and ecosystems within and beyond the tropical Pacific sector.
120 Years of AMOC Variability Reconstructed From Observations Using the Bernoulli Inverse
Authors: Fraser Neil J. , Cunningham Stuart A.
Published: September 2021

Determining the long‐term nature of the Atlantic Meridional Overturning Circulation (AMOC) presents a major step in understanding ocean temperature forcing, and is crucial both for placing the recently observed AMOC slowdown in the context of climate change and for predicting future climate. We present a time series for AMOC strength over the last 120 years which is derived solely from observations. Application of the Bernoulli inverse to hydrography yields the general geostrophic circulation in the North Atlantic without requiring additional sea surface height information, allowing AMOC evaluation in the pre‐satellite era. AMOC varies on a multidecadal timescale, leading the Atlantic Multidecadal Variability (AMV) in sea surface temperature by 2.5 years. We consider the dynamics of the implied AMOC/AMV coupling, and hypothesize that the low‐frequency variability in both parameters is driven by large‐scale density anomalies circulating in the AMOC.
Surface Deformation and Seismicity Induced by Poroelastic Stress at the Raft River Geothermal Field, Idaho, USA
Authors: Li Bing Q. , Khoshmanesh Mostafa , Avouac Jean‐Philippe
Published: September 2021

We investigate the relative importance of injection and production on the spatial‐temporal distribution of induced seismicity at the Raft River geothermal field. We use time‐series of InSAR measurements to document surface deformation and calibrate a hydro‐mechanical model to estimate effective stress changes imparted by injection and production. Seismicity, located predominantly in the basement, is induced primarily by poroelastic stresses from cold water reinjection into a shallower reservoir. The poroelastic effect of production from a deeper reservoir is minimal and inconsistent with observed seismicity, as is pore‐pressure‐diffusion in the basement and along reactivated faults. We estimate an initial strength excess of ∼20 kPa in the basement and sedimentary cover, but the seismicity rate in the sedimentary cover is four times lower, reflecting lower density of seed‐points for earthquake nucleation. Our modeling workflow could be used to assess the impact of fluid extraction or injection on seismicity and help design or guide operations.