bluuebunny/crossref_metadata_2025 huggingface dataset:
A Mulher e sua atuação no âmbito da logística: Um estudo de casos múltiplos na região do cariri
Authors: Borges Maria Taina Araujo Silva , Oliveira Alyne Leite de
Published: January 2019

Em um cenário onde a mulher tem cada vez mais espaço no mercado de trabalho, ainda se percebe algumas restrições quanto à sua atuação em algumas áreas. No âmbito da logística, campo vasto em atuação e de grande importância não apenas nas organizações, mas no direcionamento das atividades diárias das pessoas, se fez importante compreender os desafios enfrentados pela mulher frente a atual conjuntura e exigências no tocante à inserção e manutenção da profissão. A pesquisa em questão traz em seu cerne além de um contexto de empoderamento feminino, uma discussão que perpassa os desafios da inserção da mulher no mercado de trabalho, adentrando o principal enfoque da gestão, que visa resultados efetivos, sendo esse estudo no âmbito da logística. Foram selecionadas por acessibilidade e julgamento do pesquisador, 04 mulheres que atuam na área de logística na cidade de Juazeiro do Norte-CE, há pelo menos 02 anos, formadas na área ou afins, entre 29 e 35 anos. Foi utilizado como instrumento de coleta de dados, um roteiro de entrevista estruturado, gravado com uso de um celular. Os resultados apontam que as profissionais entrevistadas estão na direção evolutiva no contexto de empoderamento feminino, demonstrando que estão não apenas aptas a atuarem no ramo da logística, mas principalmente, tem competência para tal. E na contramão dos preconceitos, ainda vigentes, se destacam em suas atuações, podendo perceber, inclusive, reconhecimentos advindos de seu trabalho e dispostas a galgar uma carreira de sucesso.
Percepção dos Gestores das Unidades Básicas de Saúde Sobre as Práticas Integrativas e Complementares
Authors: Plácido André Lima , Morais Karla Cavalcante Silva de , Silva Carla Pequeno da , Tavares Felix Meira
Published: January 2019

Com base na existente crise do paradigma da medicina moderna executada no Sistema Único de Saúde, surgiu a necessidade de integrar práticas de saúde não convencionais e beneficiar a integralidade na atenção à saúde. Denominadas como  Práticas Integrativas e Complementares em saúde, com a criação da Política Nacional de Práticas Integrativas e Complementares pretendeu-se assegurar o acesso aos usuários da atenção básica  às medicinas tradicionais e complementares. O objetivo do estudo foi identificar o conhecimento e opiniões dos gestores de saúde que atuam nas Unidades Básicas de Saúde sobre as Práticas Integrativas e Complementares. Estudo do tipo qualitativo. A coleta de informações ocorreu no período de outubro de 2018, por meio entrevistas com os gestores de uma Unidade de Saúde Básica. Os resultados mostraram desconhecimento dos gestores com relação às políticas nacionais de saúde que preconizam as práticas integrativas, denotando um desafio para sua implementação na atenção básica.
A Importância do E-Commerce para o Processo de Compras dos Clientes da Cidade de Juazeiro do Norte
Authors: Silva Francisca Alberto da , Queiroz Herminig Everson Matos
Published: January 2019

Este presente trabalho tem o enfoque na discussão sobre o E-commerce, em que se procura apresentar aspectos relevantes no que se refere ao processo de compras online por clientes da cidade de Juazeiro do Norte – CE. Dentro deste contexto, o comércio eletrônico tem se mostrando uma ferramenta de grande importância para troca de informações, transações on-line e definindo um tipo de consumidor com características e perfil específico - o E-consumidor. Por isso, o objetivo geral deste estudo foi demonstrar a importância do E-commerce para o processo de compras dos clientes localizados na cidade Juazeiro do Norte. Já os objetivos específicos intentaram evidenciar o conceito de e-commerce; identificar como funciona o processo de compras dos clientes; investigar o perfil dos consumidores, assim como as características dos clientes; mostrar os dispositivos mais utilizados para efetuar compras e o período mais utilizado pelos consumidores para efetuar transações on-line; realizar um levantamento dos principais benefícios relacionados aos clientes quando efetuam compras na internet. A metodologia da pesquisa é de natureza quantitativa, descritiva e exploratória, baseando-se na pesquisa de campo, fundamentada na opinião de uma amostragem aleatória simples de 50 consumidores, efetuada nas proximidades do Cariri Garden Shopping na cidade de Juazeiro do Norte – CE. Para instrumento de coleta de dados, foi realizada a aplicação de um questionário composto por 13 perguntas fechadas. Dessa forma, este estudo que foi efetuado tem a objeção de mostrar como resultado, se os consumidores do Município de Juazeiro do Norte - CE estão aptos a comprar on-line.
Políticas e Programas Públicos que Oportunizam a Inserção do Jovem no Mercado de Trabalho
Authors: Silva Andreza Bispo da , Costa Antonia Valdelucia
Published: January 2019

O presente trabalho expõe a relação do jovem com o mercado de trabalho e quais políticas/programas públicos existem para auxiliar o mesmo, analisando as dificuldades enfrentadas para seu ingresso no mundo do trabalho, já que se trata de um mercado que cada vez mais exige pessoas qualificadas e que possuam experiência profissional, pesquisando quais políticas/programas púbicos foram criados para estimular a inserção dos jovens no mercado de trabalho, as regras de participação em tais programas. Em especial o Programa Jovem Aprendiz que estar estabelecido na Lei 10.097 de 2000, pode-se dizer que se trata da junção dos outros programas criados anteriormente. Com base nessa lei é feito o contrato de aprendizagem onde estão estabelecidos todos os direitos do Jovem Aprendiz. A pesquisa de cunho bibliográfico foi feita com base em artigos, livros, lei e sites confiáveis, sem alterar o ambiente natural das informações, apresentando as políticas/programas que possibilitam ao jovem capacitação, experiência profissional e melhores oportunidades no mercado de trabalho.
Administração Tributária Municipal
Authors: Viana Rafaela Lopes , Costa Antonia Valdelucia
Published: January 2019

O presente estudo trouxe uma abordagem sobre tributos, no qual se conhecimentos sobre a administração pública no âmbito de arrecadação. Os impostos têm sua alíquota diferentes em determinadas competências de arrecadação, pois a União, estado, Distrito Federal e municípios possuem impostos específicos de sua inteira competência.  A esfera municipal é responsável pela arrecadação dos impostos: IPTU, ITBI e ISS. A origem dos imposto remota à antiguidade, e veio se aperfeiçoando no decorrer dos séculos. A pesquisa feita, objetivou apresentar os impostos arredados pelos municípios, as etapas de arrecadação municipal, e o sistema tributário nacional em todas as suas esferas. Para tanto, utilizou-se da metodologia bibliográfica, tendo por base obras de autores renomados e pesquisas feitas em lei e sites confiáveis. O município tem sua autonomia na cobrança de determinados impostos e a sua aplicação deve estar voltada para o bem-estar social.
ASUPAN MAKANAN PADAT ENERGI RENDAH MIKRONUTRIEN PADA REMAJA STUNTED OBESITAS USIA 15-18 TAHUN DI KOTA SEMARANG
Authors: Puspitasari Yulia , Sulchan Muhammad , Nissa Choirun
Published: January 2019

Latar Belakang: Kejadian stunted obesitas pada remaja disebabkan karena adanya perpindahan pola konsumsi tradisional menjadi western. Makanan ini mengandung tinggi lemak, miyak dan gula namun keberadaan zat gizi mikronutrien sangatlah minim. Makanan padat energi rendah mikronutrien terbagi menjadi 5 kategori yaitu visible fat, sweeteners, dessert, snack asin dan lain-lain. Terjadinya status gizi kurang secara kronis dan mengalami stunted berkaitan dengan terjadinya remaja obesitas. Oksidasi lemak yang rendah menyebabkan lemak dipecah lebih lama sehingga terjadi penumpukkan lemak pada tubuh.Tujuan: Menganalisis perbedaan asupan makanan padat energi rendah mikronutrien pada remaja stunted dan stunted obesitas usia 15-18 tahun di kota Semarang Metode: Penelitian ini merupakan penelitian cross-sectional dengan populasi remaja SMA di Semarang. Subjek penelitian diambil dengan cara cluster random-sampling antara kelompok urban dan sub-urban. Besar sampel sebanyak 42 orang remaja terdiri dari 21 remaja stunted dan 21 remaja stunted obesitas. Hasil: Didapatkan prevalensi remaja stunted obesitas sebesar 1,9%. Sebanyak 53,8% anak stunted obesitas mengkonsumsi makanan padat energi dengan rata-rata konsumsi yaitu sebesar 2,92 kkal/gr. Jenis makanan padat energi rendah mikronutrien yang sering dikonsumsi oleh remaja stunted obesitas yaitu visible fat. Kelompok remaja stunted obesitas memiliki rerata asupan kolesterol dan natrium lebih tinggi dibandingkan kelompok remaja stunted. Berdasarkan hasil analisis statistik terdapat perbedaan secara bermakna (p=0,004 dan p=0,011). Pada remaja stunted obesitas, sebesar 37% energi berasal dari makanan padat energi rendah mikronutrien. Simpulan: Asupan makanan padat energi rendah mikronutrien pada remaja stunted obesitas lebih tinggi dibandingkan remaja stunted. Rerata asupan kolesterol dan natrium dalam makanan padat energi rendah mikronutrien pada kelompok remaja stunted obesitas lebih tinggi secara bermakna.
JASA DAN ETIKA LINGKUNGAN UNTUK PENGENDALIAN AIR DAN BANJIR SEBAGAI DASAR PENGELOLAAN DAS SERANG
Authors: Setyawan Agung , Gunawan Totok , Dibyosaputro Suprapto , Giyarsih Sri Rum
Published: January 2019

Penelitian ini merupakan kasus di DAS Serang Kabupaten Kulonprogo D.I. Yogyakarta. Bertujuan untuk menilai sebaran spasial jasa lingkungan untuk pengaturan tata air dan banjir sebagai dasar untuk Pengelolaan kelestarian sumberdaya air DAS di DAS Serang, Kabupaten Kulonprogo D.I. Yogyakarta. dengan metode dengan pendekatan jasa lingkungan menggunakan dua variable penaksir yaitu penggunaan lahan dan ecoregion. Masing-masing variable dinilai jasa lingkungannya terhadap pengaturan tata air dan banjir, yang kemudian disintesis menggunakan metode AHP menghasilkan nilai koefisien jasa lingkungan pengaturan tata air dan banjir. Dari nilai koefisien tersebut diolah dan dianalisis dengan teknis GIS menghasilkan sebaran spasial nilai jasa lingkungan pengaturan tata air dan banjir yang kemudian dilakukan pembagian kelas menjadi 5 kelas jasa lingkungan pengaturan tata air dan banjir yaitu kelas sangat tinggi, tinggi, sedang, rendah dan sangat rendah. Hasil dari penelitian ini menunjukkan bahwa: untuk DAS Serang Kabupaten Kulonprogo D.I. Yogyakarta pada daerah hulu berpontensi sebagai jasa pengaturan tata air dan banjir. Terutama di Kecamatan Kokap dengan persentase luasan jasa lingkungan pengaturan tata air dengan kelas sangat tinggi sebesar 85% dari luas Kecamatan Kokap. Sedangkan untuk etika lingkungan DAS serang Kab Kulonprogo D.I. Yogyakarta terdapat tiga kelas etika lingkungan di wilayah DAS yaitu untuk wialayah Hulu mempunya kelas Etika Lingkungan Rendah, Wilayah tengah kelas etika lingkungan sedang dan wilayah hilir kelas etika lingkungan.
Down-regulation of miR-539 indicates poor prognosis in patients with pancreatic cancer
Authors: Yu Haibo , Song Hongliang , Ma Zhongwu , Ji Wu
Published: January 2019

It has been demonstrated that miR-539 plays an important role in the development and progression of tumors. The purpose of this study was to analyze the correlation between the expression level of miR-539 and the clinicopathological features and prognosis of patients with pancreatic cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the expression level of miR-539 in 60 patients with pancreatic cancer. It was found that miR-539 gene expression was down-regulated in pancreatic cancer compared with that in paracancerous tissues. In addition, the expression level of miR-539 was inversely correlated with tumor differentiation (poorly to moderately differentiated vs. well differentiated, P=0.006), lymph node metastasis (positive vs. negative, P=0.006), clinical stage (III-IV vs. I-II, P=0.002), CA199 (≥200 vs. <200, P=0.019) and distant metastasis (positive vs. negative, P=0.035). The survival time of pancreatic cancer patients with low expression of miR-539 was significantly shorter than that of patients with high expression of miR-539. Multivariate analysis suggested that miR-539 expression level was an independent prognostic indicator for patients with pancreatic cancer (P=0.025). Down-regulation of miR-539 may be a potentially unfavorable prognostic factor for patients with pancreatic cancer, and further studies are needed to confirm our conclusion in the future.
Criteria for New Element Discovery: Providing Assurance in a Field of Allure and Romance
Authors: Hofmann Sigurd
Published: January 2019

Allure and romance are rarely expected in an article presented under the bulky headline “Criteria that must be satisfied for the discovery of a new chemical element to be recognized.” However, the members of the Transfermium Working Group (TWG) worked out a most fascinating publication on a difficult subject during the years from 1988 to 1991 [1].
Looking Backwards and Forwards at the Development of the Periodic Table
Authors: Scerri Eric
Published: January 2019

Since the periodic table has reached the ripe old age of 150 years it may be an appropriate time to look back at the development of this unique scientific icon. It is also an opportunity to look forwards to any changes that the periodic table may undergo in view of the ever-growing list of new elements that continue to be synthesized. The way that the past and future will be examined in this article will be to follow a main thread that focuses on the number of columns in the periodic table at various stages in its development.
Isotopic Abundances and Atomic Weights: IUPAC Commission II.1 Today
Authors: Meija Juris
Published: January 2019

It is hard to imagine IUPAC without the Periodic Table, and in turn, without atomic weights. As IUPAC celebrates its centennial, its oldest body, the Commission on Isotopic Abundances and Atomic Weights (CIAAW) turns 120. The parent Commission was formed in March 1899 and its inaugural task was to decide the atomic weight standard: should it be based on hydrogen or oxygen? Although the issue was settled in favor of oxygen, when the CIAAW formally joined the IUPAC in 1919, the question of the atomic weight scale was back for debate suggesting that many issues before this Commission transcend their scientific merit. In fact, many view the Periodic Table and changes therein as a part of larger cultural fabric of science so any changes are likely to be debated for a long time.
Combining Data Analytics with Team Feedback to Improve the Estimation Process in Agile Software Development
Authors: Vetrò Antonio , Dürre Rupert , Conoscenti Marco , Fernández Daniel Méndez , Jørgensen Magne
Published: January 2019

We apply a mixed research method to improve the user stories estimation process in a German company following agile software development. We combine software project data analytics with elicitation of teams’ feedback, identify root causes for wrong estimates and propose an improved version of the estimation process. Three major changes are adopted in the new process: a shorter non numerical scale for story points, an analogy-based estimation process, and retrospectives analyses on the accuracy of previous sprints estimates. The new estimation process is applied on a new project, and an improvement of estimates accuracy from 10% to 45% is observed.
Strong Reachability of Reactions with Reversible Steps
Authors: Virágh Eszter , Kiss Bálint
Published: January 2019

The controllability of reactions is an important issue in the chemical industry. The control of reactions is of great practical interest in order to ensure the energy- and time-efficient production of compounds. This paper studies the dynamical models of some chemical reactions in order to verify their controllability with regard to a candidate input signal, namely the change in the ambient temperature of a reaction.
Production of A Biolubricant by Enzymatic Esterification: Possible Synergism Between Ionic Liquid and Enzyme
Authors: Bedő Zsófia , Bélafi-Bakó Katalin , Nemestóthy Nándor , Gubicza László
Published: January 2019

The possible replacement of lubricants with fossil-fuel sources and the manufacture of biolubricants with more beneficial features were studied. Oleic acid and isoamyl alcohol were reacted with an enzyme in an ionic liquid. During the reaction conventional as well as microwave heating was applied. After the experimental determination of the optimal reaction parameters, it was unexpectedly found that a synergistic effect occurred by applying ionic-liquid and microwave-heat treatment simultaneously. The enzyme exhibited a much higher level of activity than the value expected based on the measurements carried out separately by using an ionic liquid instead of an organic solvent and microwave-heat treatment or a conventional method. In the experiments with recycled enzyme it was found that ionic liquid maintained the enzyme more effectively, as if it was immobilized by it: the enzyme managed to maintain its activity and recycling ability.
The Initial Magnetic Susceptibility of Dense Aggregated Dipolar Fluids
Authors: Nagy Sándor
Published: January 2019

To correlate the dipole moment and density dependence of the initial magnetic susceptibility on the basis of the former related theories and the probability analysis of chain formation, physically based analytical correlation equation was derived. After the local magnetic field strength and the chaining probability between two particle have been determined the chain and particle distributions came from the geometric distribution. The initial magnetic susceptibility was resulted from the summation of Langevin initial susceptibility of k-length chains. Two particles were considered in a chain if the interaction energy between them was below a certain limit. By varying slightly this energy limit around 70–75 % good agreement has been obtained between the simulation and theoretical data. Monte Carlo simulations were used to calculate the initial magnetic susceptibility of dipolar hard sphere system at different dipole moments and densities.
Effects of Different Heat Treatments on The Chemical and Microbiological Characteristics of Egg-Free and Quail Egg Dried Pasta
Authors: Szedljak Ildikó , Tóth Viktória , Tormási Judit , Kovács Anikó , Somogyi László , Sipos László , Kiskó Gabriella
Published: January 2019

In Hungary, dried pasta products are very popular amongst all groups of society. In recent years the demand for not only dried pasta made from hen eggs (Gallus gallus domesticus) but from alternative types of ingredients has increased. However, according to the literature the chemical and microbiological characteristics of this type of pasta have yet to be studied in depth. The effects of the use of quail eggs and heat treatments at different temperatures were studied by chemical and microbiological measurements. The activity of oxidative enzymes and nutritional characteristics (water-soluble total polyphenol content, water-soluble antioxidant capacity, peroxidase enzymatic activity, water-soluble protein content and yellow pigment content) was tested during our experiments. The data were evaluated by relevant statistical methods. Significant differences were found both between heat treatments and between the egg content of the dried pasta samples. The peroxidase enzymatic activity and yellow pigment content increased with temperature. However, the usage of quail eggs provides a higher water-soluble protein content and water-soluble antioxidant capacity. The presence of microorganisms is decreased by increasing the drying temperature. The number of all the examined microorganisms was within limits.
Optimal Design and Operation of Buffer Tanks Under Stochastic Conditions
Authors: Tarcsay Bálint Levente , Mihálykó-Orbán Éva , Mihálykó Csaba
Published: January 2019

Safety regulations demand the elimination of random mistakes and the reliable operation of production units. However, the control and maintenance of batch and semi-continuous processes haalways been difficult. In this paper, a way of preventing malfunctions in batch and semi-continuous processes is presented by using appropriately designed buffer tanks. A stochastic model was investigated in which batch and continuous subsystems were linked by an intermediate storage tank. The main concern was the reliability of the system. Reliable operation was defined as neither the exhaustion of raw materials nor the excessive accumulation of them. The counting processes that describe the random batch-input and random batch-output processes are supposed to be independent homogeneous Poisson processes with different rates. By introducing a function that describes the material in storage, reliable operation is defined as when this function satisfies two inequalities for a time interval of any duration. By applying probabilistic methods, an integral equation is set up for the the reliability. Nevertheless, its analytical solution cannot be determined, hence the values according to a Monte Carlo simulation are approximated. By applying this method, a link could be identified between the necessary initial buffer and tank capacities that belong to a reliability level. Economic investigations were conducted to help determine the optimal initial buffer and tank capacities that satisfy the appointed reliability level.
Analyzing a generalized pest-natural enemy model with nonlinear impulsive control
Authors: Li Changtong , Tang Sanyi
Published: January 2019

Due to resource limitation, nonlinear impulsive control tactics related to integrated pest management have been proposed in a generalized pest-natural enemy model, which allows us to address the effects of nonlinear pulse control on the dynamics and successful pest control. The threshold conditions for the existence and global stability of pest-free periodic solution are provided by Floquet theorem and analytic methods. The existence of a nontrivial periodic solution is confirmed by showing the existence of nontrivial fixed point of the stroboscopic mapping determined by time snapshot, which equals to the common impulsive period. In order to address the applications of generalized results and to reveal how the nonlinear impulses affect the successful pest control, as an example the model with Holling II functional response function is investigated carefully. The main results reveal that the pest free periodic solution and a stable interior positive periodic solution can coexist for a wide range of parameters, which indicates that the local stability does not imply the global stability of the pest free periodic solution when nonlinear impulsive control is considered, and consequently the resource limitation (i.e. nonlinear control) may result in difficulties for successful pest control.
On further refinements for Young inequalities
Authors: Furuichi Shigeru , Moradi Hamid Reza
Published: January 2019

In this paper sharp results on operator Young’s inequality are obtained. We first obtain sharp multiplicative refinements and reverses for the operator Young’s inequality. Secondly, we give an additive result, which improves a well-known inequality due to Tominaga. We also provide some estimates for the difference A1/2(A−1/2BA−1/2)vA1/2-{(1-v)A + vB} for v∉[ 0,1].
Global stability of a distributed delayed viral model with general incidence rate
Authors: Ávila-Vales Eric , Canul-Pech Abraham , Rivero-Esquivel Erika
Published: January 2019

In this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria. By using the Lyapunov functional and LaSalle invariance principle, we obtained the conditions of global stabilities of the infection-free equilibrium, the immune-exhausted equilibrium and the endemic equilibrium. Numerical simulations are given to verify the analytical results.
Boundary value problems of a discrete generalized beam equation via variational methods
Authors: Liu Xia , Zhou Tao , Shi Haiping
Published: January 2019

The authors explore the boundary value problems of a discrete generalized beam equation. Using the critical point theory, some sufficient conditions for the existence of the solutions are obtained. Several consequences of the main results are also presented. Examples are given to illustrate the theorems.
Educação, Comunidade e Cultura Popular
Authors: Michelon Francisca Ferreira
Published: January 2019

No conjunto de textos reunidos neste terceiro número da Expressa Extensão encontra-se a dissonância entre o entendimento e a prática extensionista da época em que Freire escreveu a obra e a da atualidade. Percebe-se na leitura dos conteúdos dos artigos que o conceito que baliza as ações aos quais se referem é o que está presente no Plano Nacional de Extensão Universitária e no texto da Resolução que estabelece as diretrizes para a extensão na educação superior brasileira. São, de tal modo, textos que indicam a boa compreensão das diretrizes extensionistas, que relatam vivências exemplares e que valorizam, na apresentação dos resultados, a intensidade da experiência formativa que a extensão promove para e com o estudante. Do mesmo modo, são conteúdos que evidenciam a presença das comunidades como agentes dos projetos e ações. Os relatos asseveram qua as comunidades já não são vistas e tratadas como os recebedores do conhecimento acadêmico, mas são entendidas como o outro com quem se estabelece o diálogo. E é por esse diálogo, que nem sempre ocorre apenas com palavras, que se revelam os condicionantes sociais e os aspectos culturais dos envolvidos. A esperada ação transformadora constrói-se, portanto, na malha dos saberes que se articulam quando os acadêmicos se deslocam ao encontro da realidade. E nessa realidade, a cultura é um fio estruturante, tramado em todas as posições da malha pelas vidas que participam do fluxo das ações.
Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis
Authors: Crown Anthony M , Roberts Brittany L , Crosby Keith , Brown Hilda , Ayers Jacob I , Hart P John , Borchelt David R
Published: January 2019

Mutations in more than 80 different positions in superoxide dismutase 1 (SOD1) have been associated with amyotrophic lateral sclerosis (fALS). There is substantial evidence that a common consequence of these mutations is to induce the protein to misfold and aggregate. How these mutations perturb native structure to heighten the propensity to misfold and aggregate is unclear. In the present study, we have mutagenized Glu residues at positions 40 and 133 that are involved in stabilizing the β-barrel structure of the native protein and a critical Zn binding domain, respectively, to examine how specific mutations may cause SOD1 misfolding and aggregation. Mutations associated with ALS as well as experimental mutations were introduced into these positions. We used an assay in which mutant SOD1 was fused to yellow fluorescent protein (SOD1:YFP) to visualize the formation of cytosolic inclusions by mutant SOD1. We then used existing structural data on SOD1, to predict how different mutations might alter local 3D conformation. Our findings reveal an association between mutant SOD1 aggregation and amino acid substitutions that are predicted to introduce steric strain, sometimes subtly, in the 3D conformation of the peptide backbone.
Improved Genome Sequence of Wild Emmer Wheat Zavitan with the Aid of Optical Maps
Authors: Zhu Tingting , Wang Le , Rodriguez Juan C , Deal Karin R , Avni Raz , Distelfeld Assaf , McGuire Patrick E , Dvorak Jan , Luo Ming-Cheng
Published: January 2019

Wild emmer (Triticum turgidum ssp. dicoccoides) is the progenitor of all modern cultivated tetraploid wheat. Its genome is large (> 10 Gb) and contains over 80% repeated sequences. The successful whole-genome-shotgun assembly of the wild emmer (accession Zavitan) genome sequence (WEW_v1.0) was an important milestone for wheat genomics. In an effort to improve this assembly, an optical map of accession Zavitan was constructed using Bionano Direct Label and Stain (DLS) technology. The map spanned 10.4 Gb. This map and another map produced earlier by us with the Bionano’s Nick Label Repair and Stain (NLRS) technology were used to improve the current wild emmer assembly. The WEW_v1.0 assembly consisted of 151,912 scaffolds. Of them, 3,102 could be confidently aligned on the optical maps. Forty-seven were chimeric. They were disjoined and new scaffolds were assembled with the aid of the optical maps. The total number of scaffolds was reduced from 151,912 to 149,252 and N50 increased from 6.96 Mb to 72.63 Mb. Of the 149,252 scaffolds, 485 scaffolds, which accounted for 97% of the total genome length, were aligned and oriented on genetic maps, and new WEW_v2.0 pseudomolecules were constructed. The new pseudomolecules included 333 scaffolds (68.51 Mb) which were originally unassigned, 226 scaffolds (554.84 Mb) were placed into new locations, and 332 scaffolds (394.83 Mb) were re-oriented. The improved wild emmer genome assembly is an important resource for understanding genomic modification that occurred by domestication.
Mitotic Cell Division in Caenorhabditis elegans
Authors: Pintard Lionel , Bowerman Bruce
Published: January 2019

Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in C. elegans are conserved across metazoan species, including humans. The C. elegans pathways tend to be streamlined, facilitating dissection of the more redundant human pathways. Here, we summarize the virtues of C. elegans as a model system and review our current understanding of centriole duplication, the acquisition of pericentriolar material by centrioles to form centrosomes, the assembly of kinetochores and the mitotic spindle, chromosome segregation, and cytokinesis.
Upala: paisajes reconstruidos por sus antiguos inmigrantes
Authors: Peters Solórzano Gertrud
Published: January 2019

Este artículo reconstruye el diverso paisaje del cantón de Upala, Costa Rica, por medio de sus antiguos pobladores de la primera mitad del siglo XX. La historia del paisaje nos la relatan los autores de las autobiografías campesinas que vivieron en ese territorio, algunos costarricenses otros nicaragüenses. El paisaje histórico es interpretado como una totalidad, uniendo variables físicas, así como sociales y culturales. Cuatro son los aspectos analizados: la integración de la tierra y la población alrededor del recurso acuático, la colonización agrícola, las redes sociales y la migración nacional y nicaragüense y la población fronteriza norte e identidad territorial.
Formas organizativas de los trabajadores bananeros afectados por el Nemagón en Costa Rica (1990-2010)
Authors: Mora Solano Sindy
Published: January 2019

En este artículo se analizan las formas organizativas de los trabajadores bananeros afectados por el agroquímico conocido como Nemagón, entre 1990 y 2010, en Costa Rica. Se plantea una reflexión en torno a tres tipos de formas organizativas: las redes de organizaciones sociales, los sindicatos y los llamados “gavilanes”, y su participación en el proceso político.
Divisiones bananeras y memoria: un acercamiento al legado de las ciudades bananeras de la United Fruit Company en Centroamérica durante el siglo XX
Authors: Conejo Barboza Luis
Published: January 2019

El presente artículo pretende analizar, a partir de la historia de las organizaciones, la relación entre memoria y las ciudades bananeras construidas por la United Fruit Company en Centroamérica durante el siglo XX. Se parte de las ideas planteadas por Charles Booth, Peter Clark, Agnes Delahaye, Stephen Procter y Michael Rowlinson con respecto al uso de la memoria social para estudiar las prácticas mnemónicas de las empresas y cómo desde esta perspectiva las compañías construyen un legado histórico para sus empleados y el público en general. Utilizando fuentes impresas de la compañía, como revistas empresariales, reportes para socios, postales, así como testimonios escritos de extrabajadores bananeros, la investigación trata de identificar la forma en cómo las ciudades bananeras se convirtieron y fueron construidas como lugares de la memoria. La ciudad bananera surge a partir de los programas del llamado “bienestar corporativo” de inicios del siglo anterior, que buscaba entre otras cosas, no solo la lealtad de los empleados, sino también que estos se sintieran bien y a gusto en las divisiones donde sus empresas se habían instalado fuera del territorio estadounidense. La mayoría de artículos, cuyo tema de investigación ha sido la relación entre ciudades y memoria, se han restringido a estudiarlas desde concepciones derivadas del nacionalismo. Este artículo demuestra cómo las empresas también generan y construyen memorias por medio de sus diferentes dependencias. De igual manera se constata cómo toda la política de bienestar corporativo que proyectó la United Fruit Company, buscaba mayoritariamente legitimar y respaldar su presencia en la región centroamericana.
La gamificación como recurso didáctico para la enseñanza de la historia
Authors: Cascante Gómez María Elena
Published: January 2019

El presente trabajo describe la importancia de la gamificación como un elemento clave en el proceso de enseñanza-aprendizaje, con el fin de generar un nuevo conocimiento histórico en el marco de la mediación pedagógica. Este enfoque pretende atender una necesidad específica que se debe fortalecer por medio de la renovación e innovación en la didáctica que se emplea en las clases de Historia por parte de los docentes en formación. Se define la gamificación, como un proceso de alfabetización en la competencia digital para la apropiación de recursos tecnológicos y su incorporación en los contextos de aprendizaje mediante procesos pedagógicos. La gamificación incorpora elementos del diseño del juego para aprovecharlos en el proceso de enseñanza-aprendizaje, pero estos no se utilizan por sí mismos, sino que se toman algunos de sus principios o mecánicas como por ejemplo los puntos, los incentivos, la narrativa, la retroalimentación, el reconocimiento o la libertad a equivocarse como medios para generar un aprendizaje significativo. El estudio describe una serie de valoraciones obtenidas de un grupo de estudiantes que está en la mitad de la carrera del Bachillerato de la Enseñanza de los Estudios Sociales y la Educación Cívica (BEESEC) de la Universidad Nacional de Costa Rica sobre sus conocimientos e impacto en la mediación pedagógica que podría generar la gamificación como estrategia de enseñanza-aprendizaje.
Transformations through “Community-First” Engagement
Authors: Andrée Peter , Findlay Isobel , Peacock David
Published: January 2019

The content in this special issue was created in the context of the Community First: Impacts of Community Engagement (CFICE, pronounced “suffice”) partnership research project, funded by the Social Sciences and Humanities Research Council of Canada beginning in 2012. As you will see in this short video, our project seeks to develop strong community-campus partnerships “by putting community first”.
Funding Social Innovation in Canada: A Conversation with Stephen Huddart and Chad Lubelsky of the McConnell Foundation
Authors: Peacock David , Huddart Stephen , Lubelsky Chad
Published: January 2019

Co-editor of this issue David Peacock interviews Stephen Huddart (President and CEO) and Chad Lubelsky (Program Director) of the McConnell Foundation, a historic supporter of postsecondary education across Canada. McConnell’s investments in community service-learning, social entrepreneurial and innovation activities and social infrastructure programs and dialogues have made them a significant partner for many Canadian higher education institutions. Yet not all community-campus engagement scholars and practitioners, and Engaged Scholar readers, may have heard McConnell articulate for itself its aims and goals for Canadian higher education and society. This interview canvasses the scope of McConnell’s work and interests in community-campus engagement, and sheds light on the actions of an influential private actor in the postsecondary sector.
Trickster Chases the Tale of Education. Sylvia Moore. Montreal, QC: McGill-Queen’s University Press, 2017. 184 pp. ISBN 978-0-7735-4907-4.
Authors: Koller Katalin
Published: January 2019

In Trickster Chases the Tale of Education, teacher and scholar Sylvia Moore explores “the intersection, the confluence, and the common ground” among diverse epistemologies and worldviews, reflecting on how this space is to be harnessed in research, learning, and teaching (p. 112). She eloquently demonstrates how decolonization, or the Idea, is anything but a moment in time to be captured or missed.
Multiparentalidade: uma análise para além da possibilidade jurídica
Authors: Endres Melina Gruber
Published: January 2019

O presente artigo aborda a temática da multiparentalidade. O estudo objetiva a reflexão acerca de sua viabilidade jurídica, especialmente no contexto brasileiro. Para possibilitar essa análise, serão considerados alguns elementos, como apontamentos sucintos sobre filiação, conceituação e delimitação da multiparentalidade, diferenciando-a de institutos similares. Também serão demonstrados os principais casos brasileiros e algumas formas semelhantes de parentalidade no direito comparado.
New records of Darevskia armeniaca (Méhely, 1909) and Darevskia valentini (Boettger, 1892) (Squamata, Sauria, Lacertidae) from Armenia and updated geographic distribution maps
Authors: Petrosyan Varos G. , Osipov Fedor A. , Bobrov Vladimir V. , Dergunova Natalia N. , Danielyan Felix D. , Arakelyan Marine S.
Published: January 2019

During field survey in 2018, we recorded in Armenia the occurrences of the parthenogenetic lizard Darevskia armeniaca and its “paternal” bisexual species D. valentini. Based on our new data and records taken from publications and museums, we update the distribution maps of these species. The new records expand the geographical boundaries of sympatric habitats of these species and provide additional data for understanding the mechanisms of reticulate evolution and hybrid speciation.
POTENSI USAHA BUDI DAYA RUMPUT LAUT DI PULAU PANJANG KABUPATEN SERANG, PROVINSI BANTEN
Authors: Soejarwo Permana Ari
Published: January 2019

ABSTRAK Pulau Panjang merupakan salah satu wilayah pesisir di Kabupaten Serang, Provinsi Banten yang potensial untuk budidaya rumput laut. Usaha ini diprediksi mampu meningkatkan pendapatan masyarakat di Pulau panjang. Penelitian ini bertujuan mempelajari potensi usaha rumput laut di Pulau Panjang Kabupaten Serang. Data dan informasi primer dikumpulkan melalui observasi lapangan, focus group discussion (FGD) dengan Dinas Kelautan dan Perikanan Kabupaten Serang, pembudidaya, perangkat desa, serta pengumpulan data sekunder. Data dianalisis secara deskriptif sehingga memberi informasi tentang potensi produksi rumput laut, rata-rata pendapatan pembudidaya dengan serapan tenaga sertanilai tambah dari komoditas rumput laut. Hasil penelitian menunjukkan luasan budi daya rumput laut 100 ha diperoleh 224 ton rumput laut kering dalam sekali panen (45 hari) dengan nilai Rp3.360.000.000 atauRp16.800.000 per petak (0.5 ha). Pada luasan 100 Ha usaha budidaya rumput laut ini dapat menyerap 1.000 orang tenaga kerja. Sehingga dapat mengurangi pengangguran. komoditas rumput laut dapat dijadikan beberapa produk dengan nilai jual tinggi.Title: Potential of Seaweed Farming Business in Pulau Panjang Serang District, Banten ProvinceABSTRACT Pulau Panjang is one of coastal area in Serang District with potential in marine and fisheries sectors. Seaweed farming is predicted to be able to increase community income in Pulau Panjang. This study aims to describe potency of seaweed farming in Pulau Panjang, Serang District. Data andinformation were collected through Focus Group Discussion (FGD), field observation and secondary data. Data were analyzed descriptively by describing about seaweed farming potency from seaweed production, average income of seaweed farmer, increased number of labour and added value of commodity. Result of this study shows that seaweed farming area of 100 ha produced 224 tons of dry seaweed in one harvest period (45 days) with value of 3.360.000 or 16.800.000 per plot area (0.5 ha). Meanwhile, it absorbs labours up to 1000 persons for 100 ha area. Thus, seaweed farming helps to reduce the number of unemployment, and it creates additional values of seaweed which they could beprocessed into numerous food products.
PELUANG PENERAPAN KONSEP BLUE ECONOMY PADA USAHA PERIKANAN DI KABUPATEN LOMBOK TIMUR
Authors: Zamroni Achmad , Nurlaili Nurlaili , Witomo Cornelia Mirwantini
Published: January 2019

Tantangan pengembangan ekonomi biru di Lombok adalah menurunnya habitat terutama rumput laut, terumbu karang dan bakau, karena tingginya tekanan ekonomi yang menyebabkan orang terlibat dalam eksploitasi sumber daya perikanan. Tujuan riset adalah mereview penerapan konsep “Ekonomi Biru” pada usaha perikanan budidaya di Kabupaten Lombok Timur. Data dan informasi dikumpulkan melalui penelusuran dokumen, laporan riset dan publikasi ilmiah terkait topik kajian. Dokumen-dokumen tersebut dianalisis secara konten (content analysis) dan direview dari aspek sosial dan ekonomiyang dijelaskan secara kualitatif. Hasil review menunjukkan bahwa 6 (enam) usaha perikanan dapat memberikan efek berganda yaitu budidaya lobster, budi daya rumput laut, pengolahan kepiting, pengolahan limbah kepala ikan, dan tambak garam mempunyai peluang menciptakan efek berganda, artinya keenam usaha tersebut dapat menciptakan alternatif mata pencaharian yang bisa berdampak pada peningkatan ekonomi rumah tanggaTitle:  Prospects of the Implementation of Blue Economy Concept on An opportunity Fisheries Bussiness in East Lombok DistrictThe challenge of developing a blue economy in Lombok is the decline of habitats, especially seaweed, coral reefs and mangroves, due to the high economic pressure that causes people to be involved in exploitation of fisheries resources. The aim of the research is to review the application of the concept of “Blue Economy” in aquaculture businesses in East Lombok District. Data and information were collected through documents investigation, research reports and scientific publications related to the topic of the study. These documents were analyzed using content analysis and reviewed from the social and economic aspects qualitatively described. The result shows that the review indicates that 6  (six) fisheries businesses can provide multiple effects namely lobster aquaculture, seaweed farming, crab processing, fish head waste treatment, and salt farming have the opportunity to create multiple effects, meaning that the six businesses can create alternative livelihoods that can has an impact on improving the household economy
Theriya Networks and the Circulation of the Pali Canon in South Asia
Authors: Wynne Alexander
Published: January 2019

This article offers further support for Lance Cousins’ thesis that the P?li canon, written down in the first century BCE in Sri Lanka, was based largely on a Theriya manuscript tradition from South India. Attention is also given to some of Cousins’ related arguments, in particular, that this textual transmission occurred within a Vibhajjav?din framework; that it occurred in a form of ‘proto-P?li’ close to the Standard Epigraphical Prakrit of the first century BCE; and that that distinct Sinhalese nik?yas emerged perhaps as late as the third century CE.
Right Thoughts at the Last Moment: Buddhism and Deathbed Practices in Early Medieval Japan, by Jacqueline Stone
Authors: Astley Ian
Published: January 2019

Right Thoughts at the Last Moment: Buddhism and Deathbed Practices in Early Medieval Japan, by Jacqueline Stone. Kuroda Institute studies in East Asian Buddhism 26. University of Hawai‘i Press: 2016. 624pp; illustrated, incl. 11 colour plates, 1 B&W illustration. Hb. $68.00 (cloth). ISBN-13: 9780824856434.
A New Molecular Taxonomy to Predict Immune Checkpoint Inhibitor Sensitivity in Prostate Cancer
Authors: Antonarakis Emmanuel S.
Published: January 2019

Immune checkpoint agents have not yet been approved for use in advanced prostate cancer. This commentary summarizes the challenges related to this issue, in light of a recently reported case of a patient with DNA mismatch-repair deficient castration-resistant prostate cancer who responded to single-agent pembrolizumab treatment.
Some metallic nanoparticles’ ignition temperature by thermodynamic consideration
Authors: Zhang Shuai
Published: January 2019

Self-propagating high-temperature synthesis (SHS) provides an attractive alternative route for the preparation of various compounds. Considering the diffusion reaction at the solid interface, the size-dependent activation energy and ignition temperature of the compounds synthesized by SHS can be used to help in modeling. Therefore, a quantitative model for size-dependent ignition temperature is established by considering energetic and physical characteristics. To the author’s knowledge, this is the first theoretical model to explore the effects of size on ignition temperature for SHS applications, with size ranging from nano- to microscale. An assumption of ideal SHS is made in the deduction of the model. As the size of reactants decreases, the ignition temperature decreases. This is because increasing the contact area and reducing the diffusion barrier between the reactants must be used specifically to calculate the reactants at the nanometer scale. The model predictions are still in good agreement with the experimental and theoretical observations for metallic aluminides and titanium carbide systems.
Desfluoretação de águas subterrâneas por adsorção e precipitação por contato em carvão ativado de osso
Authors: Da Costa Adilson Ben , Rodrigues Gisele Steil , Baumann Luiza , Dos Santos Ronaldo Bastos , Klamt Rodrigo Augusto , De Carvalho Fernando Sansone , Kirst Alcido , Lobo Eduardo Alexis
Published: January 2019

A ingestão de flúor em excesso via água potável destaca-se como problema de saúde pública. O flúor em concentrações adequadas (6-9 mg L-1) atua na prevenção da cárie dental, entretanto, em quantidades acima do estabelecido pela portaria 2914/2011 do Ministério da Saúde (1,5 mg L-1), causa fluorose dental. Assim, o principal objetivo deste trabalho foi o desenvolvimento de um protótipo para desfluoretação de águas subterrâneas, utilizando carvão ativado de osso como meio adsorvente. Após saturação, foram adicionados sais de cálcio e fósforo para auxiliar na desfluoretação. O sistema foi construído utilizando um tanque de adsorção preenchido com 235 kg de carvão ativado de osso, tendo uma concentração de fluoretos entre 2,1 e 3,7 mg L-1. O sistema foi operado com vazão entre 600 a 1.000 L h-1 tratando 410.535 litros de água, destacando que o nível de fluoretos na água foi ≤ 1,5 mg L-1. As vazões das soluções de cloreto de cálcio (4 g L-1) e dihidrogeno fosfato de potássio (4 g L-1) foram aproximadamente de 1,3 e 2,0 L h-1, respectivamente. Os resultados demonstraram que a técnica de precipitação por contato destaca-se como uma alternativa viável para o desenvolvimento de sistemas de desfluoretação de água para consumo humano.