bluuebunny/crossref_metadata_2025 huggingface dataset:
Nghiên cứu liên quan giữa di căn hạch với một số yếu tố mô bệnh học của ung thư hắc tố da
Authors: Phương Vũ Thanh , Chủ Nguyễn Văn
Published: May 2021

Ung thư hắc tố da là bệnh lý rất ác tính, tiến triển nhanh, di căn sớm, kết quả sống thêm sau điều trị thấp. Chúng tôi chọn đề tài này vì Việt Nam chưa có nghiên cứu. Mục tiêu là nghiên cứu đặc điểm lâm sàng, mô bệnh học và liên quan giữa di căn hạch với một số yếu tố mô bệnh học của ung thư hắc tố da tại viện K. 60 bệnh nhân ung thư huyết tố da giai đoạn II, III được điều trị tại viện K. Thiết kế mô tả hồi cứu và tiến cứu. Hay gặp tuổi 40 - 70, nữ/nam 1,2. Xuất hiện nhiều chi dưới 70%, u màu đen 65%, nốt ruồi to 38,3%, thể lan tràn nông 73,3%, di căn hạch 28,3%, bề dày u > 2 mm 86,7%,, loét 23,3%, Clark IV,V 78,4%. Giai đoạn phát triển thẳng 90%, xâm nhập mạch 18.3%, vệ tinh 31.7%. nhóm thưa thớt lympho xâm nhập 61,1%. Di căn hạch thể nốt 75%. Di căn hạch nhóm T3, T4 cao hơn T1, T2, 34% so với 7,7%, nhóm có loét cao hơn nhóm không loét, 42,8% so với 23,9%, ở Clark IV - V cao hơn Clark I - II - III, 34% so với 7,7%, nhóm có giai đoạn phát triển thẳng đứng cao hơn nhóm không có thẳng đứng, 31,5% so với 0%, nhóm có xâm nhập mạch cao hơn nhóm không có, 90,9% so với 14,3%, nhóm có nhân vệ tinh cao hơn nhóm không có, 47,4% so với 19,5%. Di căn hạch 0% nhóm lympho bào xâm nhập dày đặc, 20% nhóm thưa thớt, 52,6% nhóm không có.Kết luận thường gặp ở tuổi 40 - 70, nữ/nam 1,2, bệnh hay gặp chi dưới, màu đen, nốt ruồi to, thể lan tràn nông, bề dày u > 2 mm, Clark IV, V, có giai đoạn phát triển thẳng đứng, di căn hạch thể nốt, nhóm thưa thớt lympho bào xâm nhập, u có loét 23,3%, di căn hạch 28,3%, xâm nhập mạch 18,3%, nhân vệ tinh 31,7%. Di căn hạch tăng khi độ dầy u tăng, loét u, Clark tăng, có giai đoạn phát triển, có xâm nhập mạch ,có nhân vệ tinh và lympho xâm nhập u giảm.
Liên quan giữa nồng độ IL6 và CRP với đặc điểm siêu âm khớp gối ở bệnh nhân thoái hóa khớp gối nguyên phát
Authors: Ngọc Nguyễn Thị Bích , Hoa Đặng Hồng , Ngọc Nguyễn Vĩnh
Published: May 2021

Mức độ tăng IL6 có thể được coi là yếu tố dự báo về các tổn thương của khớp ở bệnh nhân thoái hóa khớp gối nguyên phát. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang 26 bệnh nhân được chẩn đoán xác định là thoái hóa khớp gối theo tiêu chuẩn ACR1991 tại khoa cơ xương khớp, bệnh viện E. Các thông tin nghiên cứu được thu thập bao gồm: lâm sàng (tuổi, giới, thời gian mắc bệnh), cận lâm sàng (Protein C phản ứng - CRP, IL - 6) và đặc điểm siêu âm khớp gối bao gồm độ dày sụn khớp, tình trạng của dịch khớp. IL - 6 được coi là tăng khi > 7 pg/ml. Kết quả nghiên cứu cho thấy 26 bệnh nhân (45 khớp gối) được lựa chọn vào nghiên cứu. Tuổi trung bình của nhóm nghiên cứu là 64,1 ± 11,4 trong đó hay gặp nhất ở lứa tuổi 60 - 69, nữ chiếm tỷ lệ 88,5%. Thời gian mắc bệnh gặp chủ yếu là 1 - 5 năm chiếm 50,0% và > 5 năm chiếm tỷ lệ là 46,2%. Về đặc điểm siêu âm khớp gối cho thấy bề dày sụn khớp ( mm) LLC là 1,95 ± 0,46; LCN là 1,91 ± 0,51 và LCT là 1,85 ± 0,51. Trong đó có 30/45 khớp có dày màng hoạt dịch chiếm tỷ lệ 66,7% và có 30/45 khớp gối có dịch khớp chiếm tỷ lệ 66,7%. Kết quả cho thấy ở nhóm có tăng IL 6 thì độ dày màng hoạt dịch và độ dày dịch khớp gối tăng hơn so với nhóm có chỉ số IL6 bình thường (p < 0,05). Kết luận, nghiên cứu của chúng tôi bước đầu đã xác định được mối liên quan giữa nồng độ IL6 trong huyết tương với độ dày dịch khớp trên siêu âm và nồng độ CRP ở bệnh nhân thoái hóa khớp gối nguyên phát.
Góngora ante la tradición poética española: la invención gongorina al trasluz de Mena y GarcilasoGóngora and the Spanish Poetic Tradition: Gongoresque Inventions in the Light of Mena and Garcilaso
Authors: Daza Juan Manuel
Published: May 2021

Góngora’s defenders on the debate about the Soledades held that the Cordoban poet had achieved that the Spanish poetic language equaled the greatness of Latin and therefore has reached its full maturity. This fact is the result of a progressive dignifying process in which Garcilaso and Mena had a crucial role, whose innovative wits were used as an example to justify Góngora’s innovation, even though Góngora’s superiority over his predecessors might be assumed.
Apolos, musas y Parnasos: la controversia sobre la distribución de las obras en los libros de poesíasApollos, Muses, and Parnassus: The Controversy Surrounding Poem Distribution in Poetry Books
Authors: Candelas Colodrón Manuel Ángel
Published: May 2021

The article pretends to narrate the process of enrichment of the Parnassus frame during the seventeenth-century(until 1672) and to study the immediate impact of the decision of González de Salas or Quevedo to distributing his poems in nine muses among his contemporary poets. In particular, our study examines the decision of three poets that can be deemed peripheric, but that will cultivate this generic distinction, albeit not without some degree of controversy or reflection from Lisbon, Francisco Manuel de Melo; from Amsterdam, Miguel de Barrios; and from Cagliari (José Delitala).
El teletrabajo y la importancia de su adopción en los sistemas jurídicos laborales de los países centroamericanos
Authors: Castillo José Alejandro
Published: May 2021

En este artículo el autor se plantea demostrar los principales beneficios económicos, jurídicos, sociales y familiares que genera la implementación del teletrabajo en los sistemas jurídicos laborales, de cara a promover su reconocimiento y regulación jurídica en los diferentes países de la región. La discusión de este trabajo, que hace parte del avance de tesis del autor para optar al grado de doctor en derecho por la Universidad Politécnica de Nicaragua, se centra en el marco teórico conceptual del informe regional “Desafíos para la implementación del teletrabajo en los sistemas jurídicos laborales de los países centroamericanos” elaborado como producto de la estancia de investigación en la Universidad de San José, Costa Rica como becario del programa de intercambio académico regional, organizado por la Secretaría General del Sistema de Integración Centroamericana y auspiciado por la cooperación española entre los meses de mayo y junio de 2016.
Nicaragua: memorias de revolución
Authors: Velásquez Flor
Published: May 2021

La revolución fue un acontecimiento de gran relevancia para Nicaragua y su historia. A partir de mi interés en estas temáticas me propongo analizar algunas fotografías de la época de revolución de Nicaragua, de algunos autores nicaragüenses y del mundo, usando las principales categorías teóricas desarrolladas por Roland Barthes en su libro “La cámara lúcida”. También, hacer un pequeño acercamiento, con ayuda de este mismo pensamiento, a la creación de la huella histórica que dejó la revolución.
An Overview of Sandstone Lead Deposits and their Relation to Red-Bed Copper and Carbonate-Hosted Lead-Zinc Deposits
Authors: Bjørlykke A. , Sangster D. F.
Published: May 2021

Deposits of galena occurring as disseminations in basal quartzitic sandstones constitute a distinct and characteristic deposit type. By world standards they are relatively minor yet they constitute an important resource in some countries.

Host rocks to the deposits are basal quartzitic sandstones deposited in low latitude positions on a sialic basement. In several areas, the basement is anomalously rich in lead relative to average granite. Depositional environments range from continental to shallow marine.

The deposits are characteristically low grade, lead dominant, pyrite free, and silver poor. A common feature is a high-grade core surrounded by a lower grade halo. If present, zinc occurs in a position stratigraphically higher than the lead.

Galena cements sand grains, with the higher grades occurring in originally more porous zones. Silica, commonly chalcedonic in the younger deposits, is the next most common cement.

The preferred genetic model involves transport of metals laterally from adjacent basement highs through permeable channels in sandstones to an environment with a sufficiently high H2S content to precipitate galena and minor amounts of other sulfides.

From a comparison of several features of these deposits with those of two other major intracratonic, sediment-hosted, base metal deposit types (red-bed copper and carbonate-hosted lead-zinc), it is concluded that these three deposit types are not only clearly separate entities in terms of their tectonic and sedimentary environments but were probably formed at different stages of continental evolution.
The Appraisal of Mineral Resources
Authors: Harris DeVerle P. , Agterberg Frederik P.
Published: May 2021

The past decade has been a time of increased awareness of the importance of mineral resources to economic growth and well being, which has resulted in demands for resource appraisals. One result has been the involvement of more geologists in the activity of appraisal. It is time to examine carefully and critically the use of geoscience in the appraisal of mineral endowment. We must consider some fundamental questions: How well can a geologist estimate undiscovered mineral endowment? How good an estimator can the geologist become, given improvements in science, appropriate methodology, and resource data? Significant improvements in the appraisal of mineral endowment and resources will be severely impeded, if not made impossible, without advances in three major areas: geology-mineral endowment theory, geological and resource data, and analytical methods. Of these three, the first two may need the greatest improvement. The accuracy by which we can relate geology to mineral endowment, whether by quantification of judgment or by mathematical models, is strongly reflective of how well our data and experience describe relevant geologic processes and endowment. In our opinion, geomathematics is a wide and challenging new field in the earth sciences. Relatively little use has been made of this opportunity because the application of geomathematics is fraught with educational, organizational, and technical difficulties. However, as the usefulness of the statistical methods is demonstrated through successful case history studies, it is likely that increasingly large numbers of geologists will be convinced of the value of this approach and a more widespread usage can be expected.
Mathematical Discussion on the Relationship Between SUTs and SIOTs
Authors: Bui Trinh , Pham Ngoc Quang
Published: May 2021

Since the 1993 System of National Accounts (SNA) and especially the 2008 SNA, traditional input-output table (IOT) of Leontief has been modified quite a lot with many variations. The supply and use tables (SUTs) seem to be substituted for the IOT, although there has not been a complete guiding to SUTs to IOT conversion.Originally in 1968 SNA, SUTs was called make and use matrices as an intermediate step to compile IOT. However, 1993 and 2008 SNA seem to replace IOT with SUTs, of which regulations make it difficult to convert from SUTs to IOT such as regulation on the size of supply and use tables and regulation on the prices of the intermediate input matrix.Some countries use computable general equilibrium (CGE) model, while others use both the CGE model and input-output analysis, so they need to convert SUTs into symmetric input-output tables (SIOTs). The construction of SIOTs is a controversial issue as regards the choice of model to construct both product-by-product and industry-by-industry SIOTs. This paper discusses the SUTs given in 1968, 1993, 2008 SNA, and the method for converting SUTs to SIOTs.Although there have been several articles on how to convert SUTs into SIOTs, this article is an effort to provide an easier, more understandable way to convert SUTs to SIOTs based on the arrangement of supply and use matrices.
The oldest tombstones in the Jewish cemetery in Tarnow
Authors: Hońdo Leszek
Published: May 2021

The Jewish cemetery in Tarnów dates from the 16th century. It has an extremely valuable group of tombstones from the 17th, 18th and early 19th century. They are monuments of sepulchral art as well as cultural testaments — not only of Tarnovian Jews, but generally of Polish Jews. The article presents the oldest tombstones in the cemetery. The preserved tombstones originate only from the second half of the 17th century.
Albertus Magnus and Thomas Aquinas on What is “Better-Known” in Natural Science
Authors: Boyer John H. , Wagner Daniel C. ,   Philosophy Documentation Center
Published: May 2021

Aristotelian commenters have long noted an apparent contradiction between what Aristotle’s says in Posterior Analytics I.2 and Physics I.1 about how we obtain first principles of a science. At Posterior 71b35–72a6, Aristotle states that what is most universal (καθόλου) is better-known by nature and initially less-known to us, while the particular (καθ’ ἕκαστον) is initially better-known to us, but less-known by nature. At Physics 184a21-30, however, Aristotle states that we move from what is better-known to us, which is universal (καθόλου), to what is better-known absolutely, which is particular (καθ’ ἕκαστον). This paper turns to two of Aristotle’s most notable medieval commentators—Albertus Magnus and Thomas Aquinas—to resolve this apparent contradiction. The key to Thomas and Albert’s solutions, we will argue, is a twofold distinction between a sense-perceptive and scientific universal, and the particulars as sensed individuals and as differentiating attributes. Our Synthetic treatment of these distinctions contributes to the ongoing scholarly effort to understand the Stagyrite’s complex theory of knowledge.
Taxonomic status of Macaronesian Eucyclops agiloides azorensis (Arthropoda: Crustacea: Copepoda) revisited – morphology suggests a Palearctic origin
Authors: Hołyńska Maria , Sługocki Łukasz , Ghaouaci Souad , Amarouayache Mounia
Published: May 2021

Macaronesia, with the exception of the Azores, is one of the few Palearctic provinces where basic taxonomic information on the freshwater copepods is still lacking. We redescribed Eucyclops azorensis, a cyclopid crustacean so far known only in the Azores, and report the occurrence of this species in Algeria and Madeira Island. Eucyclops azorensis was formerly considered to be a subspecies of E. agiloides (East Africa); therefore, the latter species is redescribed here as well based on type and non-type material. Morphological comparisons between E. azorensis, E. agiloides and other taxa (E. serrulatus and E. roseus), assumed to be closely related to our target species, support a closer relationship between E. azorensis and E. serrulatus (Palearctic) than between E. azorensis and E. agiloides (Afrotropical). The slight differences between E. azorensis and E. serrulatus in the surface ornamentation of the antennal coxobasis and intercoxal sclerites of legs 1 and 4 suggest a relatively young separation of these lineages. Eucyclops agiloides is morphologically close to E. roseus (temperate and subtropical Asia, southeastern Europe, East Africa). The numerous and clear-cut differences indicate a species rather than subspecies-level differentiation between E. agiloides and E. roseus, unlike what was formerly proposed in the taxonomic literature.
Despot Stefan Lazarevic and our times
Authors: Kajtez Ilija
Published: May 2021

Despot Stefan Lazarevic is neither the most notable nor the most prominent figure in Serbian history, but his life is important, remarkable, and insufficiently studied. Stefan Lazarevic lived during the tragic and bloody aftermath of the Battle of Kosovo, the watershed moment in the history of the Serbs. He successfully led the country after the Golgotha on Kosovo Field. The greatest challenge for research is his complex character and the difficult, unsettled times during which he lived, ruled and battled. It is necessary to discover the permanent legacy of Stefan Lazarevic and the message his life has for us today through a study of his life, leadership and politics. On the side of his mother Milica, he was a descendant of the Nemanjić dynasty. Both of his parents - Emperor Lazar and Empress Milica, are saints, and he was also canonized. Despot Stefan was one of the greatest knights of his time, and a member of the "Golden order". He established Belgrade as the capital of Serbia. Unfortunately, the only monument in Belgrade dedicated to him is located in Kalemegdan and unworthy of a statesman, knight and hero of his stature. Stefan Lazarevic suffered extreme personal sacrifices and humiliations as he was forced, with his brother Vuk, to bring his sister Olivera to the harem of Sultan Bayezid's, the man who had killed their father. He was also forced to fight as a Turkish vassal in several battles, the most famous one being the Battle of Angora, after which his vassalship with the Turks ended. Despot Stefan struggled for power with his brother Vuk. Stefan Lazarevic built the magnificent Manasija monastery, as his endowment to his people, along with the Resava school of transcription. He also authored the exquisite Slovo ljubve. In the year 2027, on the occasion of the 600 anniversary of the death of Stefan Nemanja, Serbs should organize a scientific meeting on this significant personage. This is necessary because, in the words of Prof. Djuro Šušnjić, we should take interest in the thoughts and beliefs of our ancestors if we would better understand ourselves.
Phenomenology of domestic violence as a socially deviant phenomenon in Serbia
Authors: Milašinović Srđan , Andrić Sanela
Published: May 2021

The authors of this paper discusses the phenomenon of domestic violence, which has deep roots, and can be traced from the age of the patriarchate to modern society. The authors explored different types of domestic violence and measures of legal protection against violence. The paper concludes with an all-important sociological approach to the study of this phenomenon. Domestic violence is an individual, group, social / national and global problem, and it is necessary to deal with it, explain it and offer solutions. In contemporary society, which must be synonymous with human rights and freedoms, no form of violence has a place.
Zmienność przepływów niżówkowych w wybranych zlewniach pogórskich i beskidzkich w latach 1988‑2017 = Variability of low flow in Polish Carpathians (foothills and Beskidy Mountains) catchments in the period 1988‑2017
Authors: Bochenek Witold , Kijowska-Strugała Małgorzata
Published: May 2021

Water flow in the Polish Carpathians was exemplified by long-term (1988‑2017) analysis of two foothill catchments (of the Skawinka and Stobnica) and two catchments in the Beskidy Mountains (of the Soła and Osława). The work allowed for the determination of the duration of low flows and outflow deficits in relation to changes in thermal and precipitation conditions, as well as land use and land cover. In the selected catchments, the 30-year period brought a decrease in the area of arable land and an increase in the area of grassland and forest. In addition built-up areas increased by 495% between 1990 and 2018. A greater susceptibility to the occurrence of total drought was noted for the Beskidy Mountains catchments, in which the duration of low flows and outflow deficit was greater than in the foothill catchments. At the same time, the mountain catchments proved less susceptible to the emergence of deep drought, on account of their higher levels of forest cover and levels of soil permeability. In regional terms, the durations of low flows and outflow deficits were greater in the catchments located in the eastern part of the Carpathians (those of the Stobnica and Osława), in line with this area’s intensified features of a continental climate.
Introducing Reproducibility to Citation Analysis: a Case Study in the Earth Sciences
Authors: Teplitzky Samantha , Tranfield Wynn , Warren Mea , White Philip
Published: May 2021

Objectives:

Replicate methods from a 2019 study of Earth Science researcher citation practices.

Calculate programmatically whether researchers in Earth Science rely on a smaller subset of literature than estimated by the 80/20 rule.

Determine whether these reproducible citation analysis methods can be used to analyze open access uptake.

Methods: Replicated methods of a prior citation study provide an updated transparent, reproducible citation analysis protocol that can be replicated with Jupyter Notebooks.

Results: This study replicated the prior citation study’s conclusions, and also adapted the author’s methods to analyze the citation practices of Earth Scientists at four institutions. We found that 80% of the citations could be accounted for by only 7.88% of journals, a key metric to help identify a core collection of titles in this discipline. We then demonstrated programmatically that 36% of these cited references were available as open access.

Conclusions: Jupyter Notebooks are a viable platform for disseminating replicable processes for citation analysis. A completely open methodology is emerging and we consider this a step forward. Adherence to the 80/20 rule aligned with institutional research output, but citation preferences are evident. Reproducible citation analysis methods may be used to analyze open access uptake, however, results are inconclusive. It is difficult to determine whether an article was open access at the time of citation, or became open access after an embargo.
Queer Perspectives in New Music
Authors: Dharmoo Gabriel , Brosin Annette , R. Green Anthony , Nickel Luke , Doolittle Emily , Henry Symon , Kasahara 笠原 貞野 Teiya
Published: May 2021

This collection of texts investigates how queerness manifests in contemporary new music practices. Six contributions by queer artists (Annette Brosin, Anthony R. Green, Luke Nickel, Emily Doolittle, Symon Henry and Teiya Kasahara 笠原 貞野) are framed by an introduction and conclusion by Gabriel Dharmoo. Dharmoo’s definition of queerness expands beyond sexual orientation and gender identity; it entertains the notion of queerness as an anti-assimilationist stance that defies normalcy, breaks down binaries and reveals the wideness of spectrums. As each statement illuminates how a marginalized experience as queer can profoundly inform ways of conceptualizing, creating, disseminating and understanding artistic output, this range of perspectives aims to broaden our understanding of queerness not only as an identity, but also as an artistic epistemology in and of itself.
Expérience de création collective en art dramatique : approches pédagogiques et apprentissages
Authors: Marceau Carole , Chaîné Francine
Published: May 2021

Cet essai à caractère ethnographique a pour objet l’analyse rétrospective d’une recherche menée en 2016. Il suit la trajectoire de deux formatrices engagées dans un processus de création en art dramatique auprès de deux groupes dont l’un est issu du milieu communautaire et l’autre, du milieu universitaire. Cette nouvelle analyse, réalisée à partir de journaux de bord, de notes de terrain et d’entretiens, a permis de faire émerger les apprentissages des formatrices et de les considérer à la lumière de ceux qu’ont acquis les participant·es. Dans cette mise en écho des différentes expériences, quatre catégories ont été dégagées, autant de conditions pour que puissent advenir des relations et des situations d’apprentissage dynamiques : l’esprit d’ouverture des formatrices, l’engagement des participant·es, la collaboration / coopération et la prise de risque de tous et de toutes.
La convergence des propositions
Authors: Plouffe Marie-Josée
Published: May 2021

Les résultats de recherche présentés dans cet article concernent la première phase d’un processus de création. Ils sont issus d’une démarche de théorisation empirique et inductive (la « grounded theory » de Glaser et Strauss, 1967; Strauss et Corbin, 1998). Ils proviennent de l’analyse de différentes collectes de données recueillies entre 2008 et 2015 auprès de personnes ayant participé à divers projets de création (comme élève, interprète, responsable de la mise en scène ou de la formation en art dramatique). Ces résultats soulèvent des dimensions implicites qui semblent avoir une incidence sur tout le processus : l’expérience ludique et symbolique. Les prendre en compte favoriserait une convergence des propositions de chaque personne impliquée. Dans cette première phase, les ajustements continuels entre chacun·e dépendent de la conscience de soi et du rapport de soi à l’autre. Ils cautionnent la potentielle fécondité du projet.
Le pouvoir créateur du langage dans la classe de théâtre
Authors: Villeneuve Lucie
Published: May 2021

Cet article expose la force du langage en contexte artistique et pédagogique. Les composantes de la compétence linguistique sont d’abord exposées à la lumière des travaux de Charles Taylor et de Paul Ricoeur, pour ensuite servir d’assise à mon étude sur le langage des metteur·euses en scène en contexte de création théâtrale, étude qui vient également éclairer les enjeux relatifs à la compétence linguistique des enseignant·es en classe de théâtre. Mes expérimentations sont mises à partie; elles démontrent comment le littéraire constitue un outil didactique précieux pour le développement de l’imaginaire, les jeux autour du langage créant des contrastes, des décalages et des effets de surprise qui éveillent la créativité.
Construire des ponts entre les communautés francophones et métisses par l’éveil aux langues : exemple d’un dispositif pédagogique proposé au primaire dans les écoles francophones et les programmes d’immersion
Authors: Dion Shirley , Hilbert Judy , Howse Cécile , Lemaire Eva , Lothian Riplea , McKenzie Athena
Published: May 2021

Dans cet article, nous rendons compte d’un projet mené dans les écoles francophones et les programmes d’immersion française autour de ressources créées en collaboration avec des Aînées Métisses, dans leurs langues ancestrales. Après nous être situés, nous expliquons comment nous avons créé des ressources vidéo et textuelles qui ont ensuite donné lieu à un dispositif éducatif inspiré de l’éveil aux languesenrichi par l’implication de la communauté locale et par l’intégration des pédagogies autochtones. Nous discutons comment le dispositif, expérimenté dans des classes au niveau des écoles primaires, a permis 1) de donner une voix et un espace inédits aux langues, cultures et vécus des Métis de l’Alberta, 2) de renouveler les pratiques enseignantes et 3) de contribuer à créer des environnements d’apprentissage plus inclusifs pour les élèves autochtones fréquentant les écoles francophones et les programmes d’immersion française, en contexte minoritaire.
Reconjuguer nos langues dans la pédagogie de la réconciliation au collégial?
Authors: Vaudrin-Charette Julie
Published: May 2021

Cet article offre une réflexion à la fois micro et macro sur la place des langues dans la pédagogie de la réconciliation au collégial. Nous y traçons un parallèle entre la discrimination systémique envers les membres des Premières Nations et les Inuits sur le territoire québécois et les discours et postures entourant la réconciliation dans l’enseignement collégial. Les vulnérabilités, résistances, responsabilités et contributions linguistiques émergeant de rencontres entre Aînées Anishinaabeg et collaborateurs autochtones et francophones dans un collège situé en territoire ancestral non cédé Anishinaabeg sont présentées comme fondements éthiques de notre questionnement. Les résultats proposent des questions clés pour les pédagogues et gestionnaires de collèges. Notre synthèse démontre les possibilités et contraintes d’une pédagogie de réconciliation conjuguée par, pour, avec et envers les langues autochtones en contexte francophone.
Processus de production, conditions de travail et gestion des ressources humaines dans des centres d’appels
Authors: Sadik Youssef
Published: May 2021

Le travail, cette valeur centrale au fil de tous les temps, continue à entacher la vie en commun de l’ensemble des catégories sociales, y compris celle au troisième âge. Tous les foyers, les familles et les espaces se constituent, directement ou indirectement, autour de cette valeur qui ne cesse de décevoir ! Dans cette nouvelle division internationale du travail, travail et dignité ne semblent pas cohabiter pour longtemps du moment qu’une partie non négligeable des travailleuses et travailleurs tente de donner sens à leur oeuvre pour ne pas la réduire à une simple quête de pain (gagne pain). Le signe le plus parlant de cette nouvelle configuration est celui des centres d’appel où des jeunes ingénieurs, des titulaires de masters et des docteurs s’adonnent à des activités répétitives dans un système routinier et à très faible valeur ajoutée, passant la journée à répondre aux appels, à donner des renseignements ou à accomplir une vente via le net. Cet article dresse une radioscopie du processus de production de ces systèmes fermés, conçus pour standardiser les tâches, minimiser l’innovation et contrôler l’exception.
Sēra dioksīda fizikāli ķīmisko īpašību pielietojums jaunu organiskās sintēzes metožu izstrādē / Development of New Organic Synthesis Methods Based on Physico-Chemical Properties of Sulfur Dioxide
Authors:   , Gulbe Krista
Published: May 2021

The Doctoral Thesis has been prepared as a collection of thematically related scientific publications comprising five publications in the SCI journals, one patent of the Republic of Latvia, and one application for patent of the Republic of Latvia. We have carried out fundamental research on the applications of SO2 as a solvent and reagent in organic synthesis. We have developed several novel synthetic methods that represent the use of liquid SO2 as a solvent for chemical transformations that proceed via carbenium ion intermediates: a) hydration of aryl acetylenes; b) hydrohalogenation of aryl acetylenes; c) ring opening of methylenecyclopropanes with halides; d) glycosylation with glycosyl fluorides. By employing DABSO as an SO2 surrogate, we have also discovered the catalytic activity of Ru(II) complexes towards sulfonylative cross coupling reaction. This finding has been applied for the synthesis of sulfonyl derived compounds.
Permeabilization-free en bloc immunohistochemistry for correlative microscopy
Authors: Fulton Kara A , Briggman Kevin L
Published: May 2021

A dense reconstruction of neuronal synaptic connectivity typically requires high-resolution 3D electron microscopy (EM) data, but EM data alone lacks functional information about neurons and synapses. One approach to augment structural EM datasets is with the fluorescent immunohistochemical (IHC) localization of functionally relevant proteins. We describe a protocol that obviates the requirement of tissue permeabilization in thick tissue sections, a major impediment for correlative pre-embedding IHC and EM. We demonstrate the permeabilization-free labeling of neuronal cell types, intracellular enzymes, and synaptic proteins in tissue sections hundreds of microns thick in multiple brain regions from mice while simultaneously retaining the ultrastructural integrity of the tissue. Finally, we explore the utility of this protocol by performing proof-of-principle correlative experiments combining two-photon imaging of protein distributions and 3D EM.
Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum
Authors: Maltese Marta , March Jeffrey R , Bashaw Alexander G , Tritsch Nicolas X
Published: May 2021

Dopamine (DA) is a critical modulator of brain circuits that control voluntary movements, but our understanding of its influence on the activity of target neurons in vivo remains limited. Here, we use two-photon Ca2+ imaging to monitor the activity of direct and indirect-pathway spiny projection neurons (SPNs) simultaneously in the striatum of behaving mice during acute and prolonged manipulations of DA signaling. We find that increasing and decreasing DA biases striatal activity toward the direct and indirect pathways, respectively, by changing the overall number of SPNs recruited during behavior in a manner not predicted by existing models of DA function. This modulation is drastically altered in a model of Parkinson’s disease. Our results reveal a previously unappreciated population-level influence of DA on striatal output and provide novel insights into the pathophysiology of Parkinson’s disease.
Electronic Nematic Ordering Driven by Atomic-scale Multipoles
Authors: Hayami Satoru
Published: May 2021

Theoretical investigations have unearthed a plethora of electronic nematic orderings driven by the spatial distribution of atomic-scale electric quadrupoles.
Exploring the behavioral reactions to a mirror in the nocturnal grey mouse lemur: sex differences in avoidance
Authors: Zablocki-Thomas Pauline B. , Boulinguez-Ambroise Grégoire , Pacou Camille , Mézier Justine , Herrel Anthony , Aujard Fabienne , Pouydebat Emmanuelle
Published: May 2021

Most mirror-image stimulation studies (MIS) have been conducted on social and diurnal animals in order to explore self-recognition, social responses, and personality traits. Small, nocturnal mammals are difficult to study in the wild and are under-represented in experimental behavioral studies. In this pilot study, we explored the behavioral reaction of a small nocturnal solitary forager—the grey mouse lemur (Microcebus murinus)—an emergent animal model in captivity. We assessed whether MIS can be used to detect a repeatable behavioral reaction, whether individuals will present a similar reaction toward a conspecific and the mirror, and whether males and females respond similarly. We tested 12 individuals (six males and six females) twice in three different contexts: with a mirror, with a live conspecific, and with a white board as a neutral control. We detected significant repeatability for the activity component of the behavioral reaction. There was a significant effect of the context and the interaction between presentation context and sex for avoidance during the first session for males but not for females. Males avoided the mirror more than they avoided a live conspecific. This pilot study opens a discussion on the behavioral differences between males and females regarding social interactions and reproduction in the nocturnal solitary species, and suggests that males are more sensitive to context of stimulation than females.
Identification of the biological function of miR-9 in spinal cord ischemia-reperfusion injury in rats
Authors: Chen Fengshou , Han Jie , Li Xiaoqian , Zhang Zaili , Wang Dan
Published: May 2021

Spinal cord ischemia–reperfusion injury (SCII) is still a serious problem, and the mechanism is not fully elaborated. In the rat SCII model, qRT-PCR was applied to explore the altered expression of miR-9 (miR-9a-5p) after SCII. The biological function of miR-9 and its potential target genes based on bioinformatics analysis and experiment validation in SCII were explored next. Before the surgical procedure of SCII, miR-9 mimic and inhibitor were intrathecally infused. miR-9 mimic improved neurological function. In addition, miR-9 mimic reduced blood-spinal cord barrier (BSCB) disruption, inhibited apoptosis and decreased the expression of IL-6 and IL-1β after SCII. Gene Ontology (GO) analysis demonstrated that the potential target genes of miR-9 were notably enriched in several biological processes, such as “central nervous system development”, “regulation of growth” and “response to cytokine”. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that the potential target genes of miR-9 were significantly enriched in several signaling pathways, including “Notch signaling pathway”, “MAPK signaling pathway”, “Focal adhesion” and “Prolactin signaling pathway”. We further found that the protein expression of MAP2K3 and Notch2 were upregulated after SCII while miR-9 mimic reduced the increase of MAP2K3 and Notch2 protein. miR-9 mimic or MAP2K3 inhibitor reduced the release of IL-6 and IL-1β. miR-9 mimic or si-Notch2 reduced the increase of cleaved-caspase3. Moreover, MAP2K3 inhibitor and si-Notch2 reversed the effects of miR-9 inhibitor. In conclusion, overexpression of miR-9 improves neurological outcomes after SCII and might inhibit BSCB disruption, neuroinflammation, and apoptosis through MAP2K3-, or Notch2-mediated signaling pathway in SCII.
A Case of BRASH Syndrome, Refractory Acidosis Necessitating Multimodal Approach to Treat it
Authors: Aytha Siva Kumar
Published: May 2021

A 69-year-old female patient, with hypertension and diabetes mellitus, was brought to Emergency Department in unresponsive state. The initial evaluation revealed that the patient had wide complex junctional bradycardia owing to hyperkalemia; hypoglycaemia, metabolic acidosis. Treatment was started in an attempt to establish definitive airway; correct glucose levels, cardiac membrane stabilisation. Interim, patient had a cardiac arrest and the Return Of Spontaneous Circulation (ROSC) was achieved and then stabilised. Later, she was found to have viral hepatitis complicated with ischemic hepatitis due to urosepsis. Managing a coding patient with severe metabolic acidosis in a resource limited setting is always challenging. Numerous paradoxes including usage of alkali therapy, choice of inotropes, achievement of haemodynamic neutral intubation is extensively studied yet debated. The present case encompasses the difficulties and possible solutions in managing such patient with refractory acidosis, Bradycardia, Renal failure, AV nodal blockers, Shock, Hyperkalemia syndrome (BRASH).
Markov-Switching Vector Autoregressive Modelling (Intercept Adjusted); Application to International Trade and Macroeconomic Stability in Nigeria (2000M1–2019M6)
Authors: Lebari Tuaneh, Godwin , Didi Essi, Isaac
Published: May 2021

Economic relationships are often modelled without consideration of a possible regime switch, the transmission from one regime to another and the duration of stay in a particular regime which are not captured by linear models. This study aimed to model and estimate the interdependence existing among Nigeria’s International Trade and Macroeconomic Stability. Specifically, this study sought to estimate and compare the estimated Models, select the best Model and determine the probabilities of stay, the expected duration of stay in a particular regime. The study adopted a quasi-experimental design. Time series data on the study variables from January 2000 to June 2019 were obtained from the Statistical Bulletin of the Central Bank of Nigeria. Models were specified accordingly, the statistical analyses were carried out using the Markov Switching Intercept Vector Autoregressive Models, the pre and post-diagnostic tests were also conducted. The unit root test results showed I (1). VAR lag length selection criteria choose lag 2. The MS-VAR analysis identified two regimes (expansion and contraction), the information criteria selected the Markov-Switching Intercept Autoregressive Heteroschedastic 2 Variance Auto-regression 2 [MSIARH (2) - VAR (2)]. The MS-VAR results in regime 1 showed that lags 1 and 2 of total export significantly affected total export and total import, Lags 1 and 2 of total import had significant effects on exchange rate while lags 1 of exchange rate and lags 1 and 2 of exchange rate had significant effects on inflation rate. In Regime 2, lag 1 of total export and lag 2 of exchange rate had significant effects on total export. Only lag 2 of inflation rate had significant effects on exchange rate while lag 2 of total export and lags 1 and 2 of exchange rate had significant effects on the inflation rate. The results also showed an 89% probability of staying in regime 1 for a duration of 8 months 8 days and 57% probability of staying in regime 2 for 2 months 10 days. It was concluded that the MSIARH (2) - VAR (2). It was recommended that the right-hand side variables should be tested for endogeneity before concluding on single or system equation. It was also recommended that the possibility of regimes should be verified before concluding on linear or nonlinear models.
Comparison of the Performance of the SANN, SARIMA and ARIMA Models for Forecasting Quarterly GDP of Nigeria
Authors: Nwokike Chukwudike C. , Okereke Emmanuel W.
Published: May 2021

This research aimed at modelling and forecasting the quarterly GDP of Nigeria using the Seasonal Artificial Neural Network (SANN), SARIMA and Box-Jenkins models as well as comparing their predictive performance. The three models mentioned earlier were successfully fitted to the data set. Tentative architecture for the SANN was suggested by varying the number of neurons in the hidden layer while that of the input and output layer remained constant at 4. It was observed that the best architecture was when the hidden layer had 10 neurons and thus SANN (4-10-4) was chosen as the best. In fitting the ARIMA/SARIMA models, the Augmented Dickey Fuller (ADF) test was used to check for stationarity. Variance stabilization and Stationarity were achieved after logarithm transformation and first regular differencing. The ARIMA/SARIMA model with lowest AIC, BIC and HQIC values was chosen as the best amongst the competing models and fitted to the data. The adequacy of the fitted models was confirmed observing the correlogram of the residuals and the Ljung-Box Chi-Squared test result. The SANN model performed better than the SARIMA and ARIMA models as it had a Mean Squared Error value of 0.004 while SARIMA and ARIMA had mean squared errors of 0.527 and 0.705 respectively. It was concluded that the SANN which is a non-linear model be used in modelling the quarterly GDP of Nigeria. Hybrid models which combine the strength of individual models are recommended for further research.
Hybrid Based Artificial Intellegence Short –Term Load Forecasting
Authors: Adebunmi Kayode O. , Adepoju Temilola M. , Adepoju Gafari A. , Bisiriyu Akeem O.
Published: May 2021

Electrical power load forecasting, which forms a key element in the power industry's electricity preparation, is used for providing required data for day-to-day system management activities and power utility unit participation. Since the statistical method is a linear model, and the load and meteorological parameters have a nonlinear relationship, the statistical method for load forecasting involves a great calculation time for parameter recognition. Using this tool for load forecasting often results in a major mistake in prediction. Due to the disadvantages of the statistical method of load forecasting Neuro-fuzzy model was used in this work. Three models: Adaptive Neuro-Fuzzy Inference System (ANFIS), Artificial Neural Network (ANN) and Multilinear Regression (MLR) were simulated in MATLAB environment and their output results were compared using root mean square error (RMSE) and mean absolute error (MAE). The ANFIS model outperforms the other models with least errors of RMSE and MAE of 2.2198% and 1.7932% respectively.
Biochemical Composition of Chlorella vulgaris Grown on Sugarcane Molasses
Authors: Saidu I. , Abu G. O. , Akaranta O. , Chukwuma F. O. , Vijayalakshmi S. , Ranjitha J.
Published: May 2021

The quest for green and sustainable biofuel to serve as alternative to the conventional fossil fuel have remained a grey area in biotechnology. The Chlorella vulgaris was isolated from the African Regional Aquacultural Centre Aluu, Port Harcourt, Nigeria. Sugarcane Molasses modified Bold Basal medium was used to cultivate the Microalgae mixotrophically. The algal culture was incubated at room temperature for 15 days with continuous aeration and 12:12 hour photoperiod under artificial illumination of 2000 lux. The proximate composition of the biomass showed 6.28%wt, 67.37% wt and 11.35%wt of moisture, volatile organic matter and Fixed carbon content respectively. The ultimate composition of Chlorella biomass revealed that Carbon was 42.46% while Oxygen content was 27.93%. Nitrogen content was 6.62% while Sulphur content was 0.82% while hydrogen content was 6.74%. The study further identified that algal biomass from C. vulgaris has the potential of serving as both nutraceuticals and bioenergy feedstock. There is need for further studies around the algae oil oriented optimization as a veritable tool for biotechnological advancements.
A Randomized Control Trails for the Assessment of Impact of Moderate Intensity Exercise on Blood Serum Creatinine Concentration among the Male Athletes
Authors: Khan Mohibullah , Khan Alamgir , Butt Muhammad Zafar Iqbal , Din Badar Mohy ud , Manan Abdul , Bhatti Shareen , Wadiat Fakiha , Jamil Muhammad
Published: May 2021

Purpose: The main purpose of the study was to examine the impact of moderate intensity exercise on blood serum creatinine concentration among the male.

Method & Materials: A randomized control trails were conducted for purpose to evaluate the effects of moderate intensity exercise on creatinine level among the subjects (Experimental Group (EG) = 10, Control group (CG). A written informed consent from all the subjects and ethical approval was taken from Gomal University Ethical Review Committee before initiating the study protocols. 5ml blood were taken from all the subjects and each blood sample was marked with separate identification code. Twelve weeks exercise (moderate intensity exercise) protocols was employed on the selected subjects. The collected blood samples were tested and thus the collected results were processed through Statistical Package for Social Sciences (SPSS, Version, 24) by applying Mean and Standard deviation etc.

Results & Conclusion: On the basis of analysis, the researcher concluded that inferentially there is no significant effect of moderate intensity exercise on BMI and Creatinine of the subjects but descriptively the experimental group shows better results in BMI and Creatinine (after the treatment)
Implementation of free breathing respiratory amplitude‐gated treatments
Authors: Hickling Susannah V. , Veres Andrew J. , Moseley Douglas J. , Grams Michael P.
Published: May 2021

Purpose

The purpose of this study was to provide guidance in developing and implementing a process for the accurate delivery of free breathing respiratory amplitude‐gated treatments.

Methods

A phase‐based 4DCT scan is acquired at time of simulation and motion is evaluated to determine the exhale phases that minimize respiratory motion to an acceptable level. A phase subset average CT is then generated for treatment planning and a tracking structure is contoured to indicate the location of the target or a suitable surrogate over the planning phases. Prior to treatment delivery, a 4DCBCT is acquired and a phase subset average is created to coincide with the planning phases for an initial match to the planning CT. Fluoroscopic imaging is then used to set amplitude gate thresholds corresponding to when the target or surrogate is in the tracking structure. The final imaging prior to treatment is an amplitude‐gated CBCT to verify both the amplitude gate thresholds and patient positioning. An amplitude‐gated treatment is then delivered. This technique was commissioned using an in‐house lung motion phantom and film measurements of a simple two‐field 3D plan.

Results

The accuracy of 4DCBCT motion and target position measurements were validated relative to 4DCT imaging. End to end testing showed strong agreement between planned and film measured dose distributions. Robustness to interuser variability and changes in respiratory motion were demonstrated through film measurements.

Conclusions

The developed workflow utilizes 4DCBCT, respiratory‐correlated fluoroscopy, and gated CBCT imaging in an efficient and sequential process to ensure the accurate delivery of free breathing respiratory‐gated treatments.