bluuebunny/crossref_metadata_2025 huggingface dataset:
Bipolar and Laplacian montages are suitable for high-gamma modulation language mapping with stereoelectroencephalography
Authors: Mitsuhashi Takumi , Iimura Yasushi , Suzuki Hiroharu , Ueda Tetsuya , Nishioka Kazuki , Nomura Kazuki , Nakajima Madoka , Sugano Hidenori , Kondo Akihide
Published: October 2024

Objective

To determine the optimal montage and vocalization conditions for high-gamma language mapping using stereoelectroencephalography.

Methods

We studied 12 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of auditory-naming related high-gamma modulations. We determined the effects of electrode montage and vocalization conditions of the response on the high-gamma (60–140 Hz) amplitudes.

Results

Compared to common average reference montage, bipolar and Laplacian montages effectively reduced the degree of auditory naming-related signal deflections in the white matter during the stimulus and response phases (mixed model estimate: −21.2 to −85.4%; p < 0.001), while maintaining those at the cortical level (−4.4 to +7.8%; p = 0.614 to 0.085). They also reduced signal deflections outside the brain parenchyma during the response phase (−90.6 to −91.2%; p < 0.001). Covert responses reduced signal deflections outside the brain parenchyma during the response phase (−17.0%; p = 0.010).

Conclusion

On depth electrode recording, bipolar and Laplacian montages are suitable for measuring auditory naming-related high-gamma modulations in gray matter. The covert response may highlight the gray matter activity.

Significance

This study helps establish the practical guidelines for high-gamma language mapping using stereoelectroencephalography.
Amplification of vibration induced nystagmus in patients with peripheral vestibular loss by head tilt
Authors: Shemesh Ari Aharon , Kattah Jorge C. , Zee David S. , Zuma E Maia Francisco , Otero-Millan Jorge
Published: October 2024

Introduction

In patients with unilateral loss of vestibular function (UVL) vibration of the skull leads to a response of the vestibulo-ocular reflex (VOR) called vibration-induced nystagmus (VIN), with slow phases usually directed toward the paretic ear. This response is thought to result from the difference between the neural discharge in semicircular canal afferents from the healthy and the affected labyrinth. The brain interprets this difference as a sustained imbalance in angular (rotational) vestibular tone, which in natural circumstances would only occur when the head was rotating at a constant acceleration.

Methods

To study this effect, we used a contemporary model of the neural network that combines sensory information about head rotation, translation, and tilt relative to gravity to estimate head orientation and motion. Based on the model we hypothesize that in patients with UVL, the brain may estimate not only a “virtual” rotation from the induced canal imbalance but also a subsequent “virtual” translation from the incorrect computation of the orientation of the head relative to gravity. If this is the case, the pattern of vibration-induced nystagmus will depend on the orientation of the head relative to gravity during the stimulation. This model predicts that this “virtual” translation will alter the baseline VIN elicited with the head upright; augmenting it when the affected ear is down and diminishing it when the affected ear is up.

Results

Confirming this hypothesis, we recorded VIN in 3 patients with UVL (due to vestibular neuritis) in upright, right ear-down, and left ear-down positions and each showed the expected pattern.

Discussion

From a practical, clinical view, our results and modeling suggest that positional VIN might reveal a hidden imbalance in angular vestibular tone in patients with UVL, when patients have equivocal signs of a vestibular imbalance, such as a minute amount of spontaneous or vibration-induced nystagmus with the head upright. This research provides insights into the underlying mechanisms of vestibular processing, the analysis of nystagmus in patients with UVL, and guides the design of a new bedside diagnostic test to assess vestibular function in patients with dizziness and imbalance.
Ziconotide and psychosis: from a case report to a scoping review
Authors: Peraire Marc , Gimeno-Vergara Rita , Pick-Martin Jennifer , Boscá Mireia , Echeverria Iván
Published: October 2024

Ziconotide is a non-opioid analgesic that acts on N-type voltage-gated calcium channels. Despite its proven effectiveness in pain treatment, it can induce neuropsychiatric symptoms. The aim of this article is to present a case of psychosis secondary to ziconotide and to explore the variety of neuropsychiatric symptoms it produces, exploring the relationship between these symptoms and the mechanism of action of ziconotide. For this purpose, a clinical case is presented as well as a scoping review of other cases published in the scientific literature. A search on Web of Science, Pubmed and Embase databases was performed on December 11, 2023, following the criteria of the PRISMA-ScR Statement. The clinical case presented shows the variety of neuropsychiatric symptomatology that ziconotide can cause in the same patient. On the other hand, 13 papers were retrieved from the scoping review (9 case reports, 4 case series), which included 21 cases of patients treated with ziconotide who presented adverse effects ranging from psychotic symptoms to delirium. In conclusion, the variety of neuropsychiatric symptoms derived from ziconotide could be related to the blockade of N-type voltage-gated calcium channels in glutamatergic and GABAergic neurons, in turn affecting dopaminergic pathways.
Transdisciplinary research on the safety case for nuclear waste repositories with a special focus on uncertainties and indicators
Authors: Heiermann Martina , Olszok Vinzent
Published: October 2024

In the search for a repository site for high-level radioactive waste in Germany, the perception of safety and trust in the actors are central to public acceptance. In communicating safety, methods of safety assessment and the role of uncertainties need to be addressed. Given the complexity of the issue, there is a need for indicators that are suitable both for assessing the long-term safety of repositories and for communicating with the general public. Similarly, there is a requirement to communicate uncertainties in an accessible manner. The TRANSENS project provides basic research in nuclear waste management (NWM) and utilizes a transdisciplinary approach: Non-experts who are not directly affected by the site selection process and who have no stated interest in NWM are involved in the research process, as are practice actors. A series of four transdisciplinary workshops was specifically designed to explore the perspectives of individuals with a high level of disciplinary knowledge but no system knowledge of NWM. Participants were selected from doctoral students in science and technology who had no prior knowledge in this area. Two of these workshops address the questions stated above and are presented here. The article describes the considerations underlying the workshop planning and implementation phases, and the content developed in the workshops on indicator selection and visualisation of uncertainties. The participants compiled a list of desirable indicator properties, which showed a high degree of congruence with the relevant literature. A proposal for a database to collect, administer and assess uncertainties shows similarities with the approach followed by the German implementer and complements it with an interactive visualisation. Transdisciplinary work is resource-intensive and its use in a research context must be carefully considered for each individual application. A transdisciplinary approach was successfully used for the purposes of method validation, method optimisation and the development of disciplinary impulses. An application of transdisciplinary approaches for optimising the Safety Case of nuclear repositories is feasible.
Giant ganglioneuroma of the mediastinum: a case report
Authors: Song Linfeng , Zhang Jiaren , Tian Binlin , Li Yongzhe , Gu Xiaoyu , Zhang Youlun , Jiang Lin
Published: October 2024

Ganglioneuroma (GN) is a rare benign neurogenic tumor that originates from the sympathetic nerves. It is extremely uncommon to find a lesion originating from the mediastinum that occupies the entire left hemithorax. In this report, we present the case of a 48-year-old female patient with a large mediastinal GN who presented with cough, sputum, and wheezing. Multislice spiral-enhanced CT and magnetic resonance imaging (MRI) revealed a large oval mass in the left thoracic cavity. The surgical operation completely resected the lesion, and the histopathological examination of the resected specimen confirmed the diagnosis of giant ganglion cell neuroma of the mediastinum. Due to the low incidence of GN and the lack of specific imaging manifestations, many radiologists may lack sufficient knowledge of GN and may be prone to misdiagnosis, resulting in delayed treatment. To enhance radiologists’ awareness of giant ganglion cell neuroma of mediastinal origin occupying the thoracic cavity, we provided detailed CT/MRI imaging information for this case, along with a brief summary of similar previously reported cases, to highlight the specific clinical and radiological features of this condition.
Case report: Diagnostic trap: a extremely rare metastatic myoepithelial carcinoma of breast
Authors: Luo Shuai , Tian Xiaoxue , Xu Ting , Wang Jinjing
Published: October 2024

Background

Myoepithelial carcinoma (MECA) is a malignant tumor primarily affecting the salivary gland, most frequently in the parotid gland. It can manifest as primary or secondary to pleomorphic adenoma or benign myoepithelioma. MECA exhibits aggressive behaviors. In particular, primary MECA is more aggressive, frequently recurring or metastasizing distantly. Its morphological and immunohistochemical characteristics overlap with various tumors, posing challenges in its recognization as a distinct entity. Consequently, MECA may be frequently misdiagnosed, mainly when occurred in the mammary gland. This chance for misdiagnosis poses significant challenges in clinical diagnosis and treatment.

Case demonstration

A 77-year-old woman with a history of pleomorphic adenoma presented with a palpable lump in the right breast for 3 months. Subsequent core needle biopsy (CNB) and modified radical mastectomy were performed, with samples subjected to histopathological examination. Based on the patient’s history, histomorphologic features, immunohistochemistry (IHC) results and results of FISH, the pathological diagnosis confirmed MECA in the mammary gland. Postoperative chemotherapy was administered, and the patient exhibited a favorable prognosis during a 40-month follow-up period.

Conclusions

Primary MECA in the mammary gland is exceedingly rare, metastasis from the salivary gland MECA to the mammary gland is even rarer and has not been previously reported. This study presents the first documented case of MECA originating from the parotid gland metastasizing to the mammary gland (also known as breast). Highlighting this case aims to raise awareness among clinical pathologists to prevent underdiagnosis and misdiagnosis of this tumor entity.
Roles of lncRNAs related to the p53 network in breast cancer progression
Authors: Song Jiarui , Cui Qiuxia , Gao Jidong
Published: October 2024

The p53 is a crucial tumor suppressor and transcription factor that participates in apoptosis and senescence. It can be activated upon DNA damage to regulate the expression of a series of genes. Previous studies have demonstrated that some specific lncRNAs are part of the TP53 regulatory network. To enhance our understanding of the relationship between lncRNAs and P53 in cancers, we review the localization, structure, and function of some lncRNAs that are related to the mechanisms of the p53 pathway or serve as p53 transcriptional targets.
Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment
Authors: Natrus Larysa , Lisakovska Olha , Smirnov Anton , Osadchuk Yuliia , Klys Yuliia
Published: October 2024

Background

Propionic acid (PA) is an intermediate product of metabolism of intestinal bacteria and may protect the intestinal barrier from disruption. The aim of the study was to investigate the apoptotic and proliferative processes in the small intestine (SI) of rats with type 2 diabetes mellitus (T2DM) on the background of metformin monotherapy and its combination with PA.

Methods

Male Wistar rats were divided: 1) control; 2) T2DM (3-month high-fat diet followed by streptozotocin injection of 25 mg/kg of body weight); 3) T2DM + metformin (60 mg/kg, 14 days, orally); 4) T2DM + PA (60 mg/kg, 14 days, orally); 5) T2DM + PA + metformin. Western blotting, RT-PCR, and scanning electron microscopy were performed.

Results

We observed profound changes in the SI of diabetic rats suggesting the disturbed intestinal homeostasis: impaired mitochondrial ultrastructure, increased cristae volume, and decreased content of proliferative marker Ki67 with almost unchanged proapoptotic caspase-3 and its p17 subunit levels. Metformin and PA monotherapies also led to an increased cristae volume, however, after their combination, a tendency to normalization of ultrastructure of mitochondria was observed. While there was a significant inhibition of proliferation in T2DM and, in greater extent, after metformin and PA monotherapies, differential influence on apoptosis in the SI was observed. While metformin inhibited apoptosis via Bax declining, PA mainly acted via caspase-3-dependent mechanism elevating its active p17 subunit.

Conclusion

PA supplementation for the improvement of diabetes-induced gastrointestinal complications concurrently with metformin may be consider as a perspective supportive therapy. Data related to PA action on SI may be valuable during the development of new treatment strategies for diabetes-induced intestinal disturbances raised after metformin treatment.
Communication dynamics of congestion warning information considering the attitudes of travelers
Authors: Yan Huining , Li Hua , Sun Qiubai , Jiang Yuxi
Published: October 2024

Traffic congestion is a serious problem faced by many cities worldwide today. Congestion warning information is one of the important influencing factors of urban road congestion; To this end, based on the dynamics of infectious diseases, a congestion warning information dissemination model considering the attitudes of travelers and the network structure was constructed. The existence and stability of the equilibrium points of non congestion warning information and congestion warning information in the model were analyzed, and the optimal control strategy of the model was proposed. Numerical simulation was conducted to verify the results of theoretical analysis, simulate and analyze the impact of changes in various parameters in the model on the dissemination of congestion warning information, and perform sensitivity analysis on several parameters. The results indicate that travelers are more inclined towards “fast” modes of transportation and have a stronger willingness to share congestion warning information. The dissemination range of warning information is wider, which can play a positive role in reducing traffic congestion pressure.
Sex differences in autonomic functions and cognitive performance during cold-air exposure and cold-water partial immersion
Authors: Kong Youngsun , Hossain Md Billal , McNaboe Riley , Posada-Quintero Hugo F. , Daley Matthew , Diaz Krystina , Chon Ki H. , Bolkhovsky Jeffrey
Published: October 2024

Introduction

This study investigated the differences between males and females in autonomic functions and cognitive performance during cold-air exposure and cold-water partial-immersion compared to a room temperature-air environment. Although several studies have investigated the effects of cold-air or cold-water exposures on autonomic function and cognitive performance, biological sex differences are often under-researched.

Methods

Twenty-two males and nineteen females participated in the current study. Subjects completed a battery of cognitive tasks based upon those used within the Defense Automated Neurobehavioral Assessment (DANA), consisting of five subtasks that assess simple and procedural reaction time, spatial manipulation, attention, and immediate memory. In total, subjects took the battery within a 15-minute period across 30-minute intervals throughout the duration of environmental exposure. Across three separate days, subjects were exposed to three different environmental conditions: room temperature air (23°C), cold air (10°C), and cold water (15°C; in which subjects were immersed up to their necks). Room temperature and cold-air conditions consisted of five sessions (about 2.5 h), and the cold-water condition consisted of three sessions (about 1.5 h). During each experimental condition, physiological data were collected to assess autonomic function, including electrodermal activity (EDA) data and heart rate variability (HRV) derived from electrocardiogram signals.

Results

Females showed slower reaction time in spatial manipulation tasks, immediate memory, and attention during cold-air exposures compared to room temperature air, whereas the performance of males were similar or better during cold-air exposures compared to room temperature air. Cold-water immersion affected the immediate memory performance of males. Both males and females exhibited smaller EDA amplitudes during cold-air and cold-water conditions compared to room temperature air. For HRV, only male subjects exhibited significantly greater values in low-frequency and very-low-frequency components during cold air exposure compared to the normal condition.

Discussion

Sex introduces important differences in cognitive performance and autonomic functions during exposure to cold-air and cold-water. Therefore, sex should be considered when assessing the autonomic nervous system in cold environments and when establishing optimal thermal clothing for performance in operational environments. Our findings can assist with determination of operational clothing, temperature in operating environment, and personnel deployment to operational sites, particularly in settings involving both males and females.
The ability of Arabidopsis to recover from Basta and its application in isolating Cas9-free mutants
Authors: Ahmed Shahbaz , Hulbert Anna K. , Xin Xin , Neff Michael M.
Published: October 2024

After successfully performing Agrobacterium-mediated CRISPR-Cas9-based gene editing in plants, isolation of the Cas9 T-DNA is essential for the stable inheritance of induced mutations. Here, we report a simple technique that allows the isolation of Cas9-free mutants, eliminating the need for outcrossing or other intricate methods. This method is based on the ability of Basta-sensitive Arabidopsis thaliana seedlings, which generally perish, to recover and grow once transplanted to Basta-free growth media. By growing gene-edited heterozygous populations of single-locus insertion Basta-resistant plants on Basta selection media, plants lacking the Cas9 T-DNA can be identified. These pale-looking plants lacking Cas9 are then rescued on media lacking the Basta to recover Cas9-free plants. The ability of seedlings to recover from Basta selection was also studied in camelina, canola, and wheat. All three crops showed different recovery rates, with wheat demonstrating the highest recovery once transplanted from Basta to normal growth media. In summary, our findings demonstrate that by harnessing the recovery capability of Basta-sensitive seedlings, we can effectively identify and rescue plants lacking the Cas9 T-DNA, enabling the isolation of Cas9-free mutants in Arabidopsis and potentially extending to other crops.
Psychological autopsies: religious and spiritual factors for suicide in cases and controls
Authors: Ali Syeda Ayat-e-Zainab , Saleem Tamkeen
Published: October 2024

Introduction

In recent years, there has been a growing body of evidence supporting the notion that spirituality and religion can improve one’s physical and mental health. Studies show that religion and spirituality play a significant role in the suicidal path. Considering the dearth of data on the patterns of suicidal thoughts, acts and related factors in Pakistan, a country with a large Muslim population and stigma with sociocultural perceptions of religious notions, the current study investigated the role of religious and spiritual factors of suicide using psychological autopsies.

Method

Purposive sampling was used to gather retrospective data records from police stations and hospital forensic departments in Rawalpindi and Islamabad, Pakistan, between January 2021 and July 2022. In total, 60 samples (30 cases and 30 controls) were used in this autopsies investigation. As with the majority of case control studies, the study sample cases were matched with the controls. At least two close bereaved family members served as the primary information sources, and data was gathered using the Semi Structured Interview Protocol for Psychological Autopsies.

Results

According to statistical analysis, both the suicide cases and the controls were comprised mostly of Muslim individuals. They follow Islam and hold the view that suicide is prohibited, forbidden, and haram in Islam. Regarding spirituality and religion, the majority of cases, according to the respondents interviewed, were not spiritual at all, while the controls are slightly spiritual. While the majority of both cases and controls had reduced interest in or practice of religious activities over the past year, a higher number of cases rarely performed and attended the religious services/activities as compared to controls.

Discussion

It was thus evident that the cases lacked significant engagement in spiritual and religious activities, and their attendance at such gatherings had notably decreased in the year preceding the suicide attempt. This decline in involvement in spiritual and religious practices might be linked to decreased levels of satisfaction, sense of belongingness, which could raise the risk of suicide. Therefore, in nations where Muslims predominate, culturally relevant suicide prevention initiatives including spiritual and religious treatments aimed at reducing the risk of suicide should be considered.
The interaction effects between depression and sleep status on asthma: a national cross-sectional study
Authors: Lai Yuxin , Zhang Xiaomei , Dong Huan , Li Mengqian
Published: October 2024

Background

Asthma, depression, and sleep problems are three significant public health issues that are closely interrelated. This study aims to explore the relationship between depression, sleep status and asthma, as well as the potential interaction among these conditions and their effects on asthma.

Method

This cross-sectional study utilized data from the 2005-2008 National Health and Nutritional Examination Survey, including information on asthma, depression, sleep status and confounding factors. Multivariate logistic regression analyses were conducted to investigate the relationship between depression, sleep status, and asthma. Subgroup analyses were conducted to test the p-interaction between depression and each stratified variable. Additionally, both multiplicative and additive approaches were employed to assess the interaction between depression and sleep status on asthma, as well as to quantify their combined effects.

Results

A total of 8,327 participants (mean age 46.53 years) were included in this study. Compared to the individuals without depression, those with depression have an increased risk of asthma [Odds ratio (OR) = 1.57, 95% Confidence interval (CI) = 1.22-2.03], and an increase in the severity of depressive symptoms is associated with a higher risk of developing asthma. Additionally, poor sleep quality, sleep disorders, and insufficient sleep was associated with an increased risk of asthma. Effect modification was observed between depression and PIR status, smoking status, and sleep disorders in relation to asthma (p-interaction <0.05). Moreover, we found a positive interaction between severe depression and excessive sleep (OR = 29.07, 95% CI = 3.24-260.38). Furthermore, we observed the quantitative additive interaction indicators between moderately severe depression and insufficient sleep [Relative excess risk due to interaction (RERI) = 1.63, 95%CI = 0.18-3.83; Attributable proportion (AP) = 0.51, 95%CI = 0.15-0.87; Synergy index (SI) = 3.92, 95%CI = 1.65-23.50] influencing asthma risk.

Conclusion

Our study revealed distinct associations between depression, the severity of depressive symptoms, poor sleep quality, sleep disorders, and insufficient sleep with asthma. Additionally, there was an interaction between moderately severe depression and insufficient sleep on asthma. Psychological and sleep assessment are essential in asthma management. Clinicians should consider the potential risk of depression and sleep problems in asthma patients and intervene. Further longitudinal research is needed to better understand the pathophysiological mechanisms behind the interactions between asthma, depression, and sleep problems.
Experiences and life circumstances of unintentionally pregnant women affected by intimate partner violence—stress factors, resources, healthcare structures and needs: a scoping review protocol
Authors: Winter Kristina , Niemann Jana , Jepsen Dennis , Brzank Petra J.
Published: October 2024

This scoping review outlines the current understanding, challenges, available resources, and healthcare needs of women affected by intimate partner violence (IPV) who experience unintended pregnancy (UP). UPs are defined as unwanted, unplanned, or mistimed pregnancies. The impact of UP is multifaceted and carries several additional risks, particularly for women who experience IPV. The experiences and living conditions, including (mental) burdens, resources, care structures, and the needs of unintentionally pregnant women who have experienced IPV, remain mostly unexplored. The review will include the following criteria: (i) reproductive-aged women who have experienced IPV and UP; (ii) publications that provide detailed accounts of the experiences, circumstances, and/or needs of women with UP who have experienced IPV. This study will utilize the JBI methodology for scoping reviews and follow the PRISMA Protocol for Scoping Reviews (PRISMA-ScR). A total of 2,325 papers and gray literature published from 2000 to the present were identified. 1,539 literature items were included in the title and abstract screening. Two researchers will independently choose studies, perform data extraction, and perform data synthesis. Quantitative data will be narratively summarized and qualitative data will be analyzed using thematic analysis. The findings will identify research gaps and provide insights into an important topic of reproductive healthcare and the (mental) health situation of a particularly vulnerable group. This will be useful in defining indications for researchers, professionals, and policymakers in public, mental, and reproductive health to conceptualize interdisciplinary and empirical healthcare support for affected women.

Systematic review registration

Open Science Framework: https://doi.org/10.17605/OSF.IO/ZMVPE.
Sex-specific socioeconomic risk factors for spontaneous subarachnoid hemorrhage—a case–control study during the 5 years before ictus
Authors: Ronne-Engström Elisabeth , Friberg Emilie
Published: October 2024

Background

There is a difference in the incidence of spontaneous subarachnoid hemorrhage (SAH) between sexes, with the majority of cases occurring in female patients. Although this phenomenon has been studied from a medical perspective, the reasons for the predominance of female cases are still unclear. Non-medical factors, such as a patient’s socioeconomic situation, can differ between female and male patients, with health implications. The aim of the study was to identify socioeconomic profiles for both sexes that may be vulnerable to developing SAH. This information could potentially be used for active preventive health efforts.

Methods

This study was based on a 7-year consecutive cohort of 890 patients with SAH treated at Uppsala University Hospital, along with a sex- and age-matched 5:1 control group from Statistics Sweden. The collected information included demographic data, income that was analyzed through “earnings” (EAs), which is defined as the sum of income and other economic compensations related to work, and “disposable income” (DI), which is the net amount that an individual can use. Pension and sickness-related absence from work were measured using early pension (EP), old age pension (OAP), sickness absence (SA), and disability pension (DP). Univariate and multivariate analyses were used.

Results

Among the women, the socioeconomic risk profile for SAH included lower education, unemployment, being registered as living single, residing in a sparsely populated municipality, and increased age. For the men, the risk profile included residing in a sparsely populated municipality and changes in civil status. Both women and men with SAH had lower EAs and DI compared to the controls. Notably, a significantly higher proportion of the women with SAH received DP compared to the controls.

Conclusion

Residing in a sparsely populated area was associated with an increased risk for SAH for both women and men. The women with SAH were more economically vulnerable, whereas the men faced a different type of vulnerability related to changes in civil status. We suggest that healthcare organizations use this information to identify individuals at risk and actively implement preventive measures according to stroke guidelines for both groups.
Were there any missing mediators between visual impairment and anxiety symptoms? Results from Chinese Longitudinal Healthy Longevity Survey
Authors: Yao Wen , Cao Yuan , Tian Yuan , Liu Yuanyuan , Hua Xin , Chen Fang
Published: October 2024

Introduction

Visual impairment, encompassing low visual acuity and visual field loss, significantly impacts the older adult population worldwide, leading to increased disability and mortality risks. Recent studies suggest a strong association between visual impairment and anxiety, particularly among older adults. This study aims to explore the relationship between visual impairment and anxiety symptoms in older adult individuals in China, and to investigate potential mediating factors.

Methods

Data for this study were derived from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), including 11,702 participants aged 65 and older. Visual impairment was assessed through self-reported visual function, while anxiety symptoms were measured using the 7-item Generalized Anxiety Disorder scale (GAD-7). Additional assessments included sleep quality and duration, exercise status, and dietary diversity. Logistic regression models and mediation analysis were employed to explore associations and mediating effects.

Results

The findings indicate that visual impairment is significantly associated with increased anxiety symptoms among the older adult (OR = 1.51, 95% CI: 1.32–1.72, p < 0.001). Mediation analysis revealed that sleep quality, dietary diversity score (DDS), and plant-based DDS significantly mediated the relationship between visual impairment and anxiety. In contrast, sleep duration, exercise, and animal-based DDS did not show significant mediating effects.

Conclusion

Visual impairment is a crucial predictor of anxiety symptoms in the older adult. Improving sleep quality and promoting a diverse plant-based diet may mitigate anxiety symptoms in this population. Interventions targeting these areas could enhance the mental health and quality of life of older adult individuals with visual impairment.
Virtual medical astronaut avatars for future deep space missions
Authors: Urlings Carole , Baselet Bjorn , Tabury Kevin , Baatout Sarah
Published: October 2024

This paper explores the telemedicine possibilities available to astronauts during spaceflight, focusing on the possible utilization of medical avatars for continuous health monitoring. Various types and sources of telemedicine are examined, along with their applications in deep space travel to address the challenges faced by astronauts and facilitate timely intervention in case of injuries and illnesses. The use of medical avatars presents a promising solution to mitigate risks and ensure effective healthcare delivery in the absence of immediate physical medical support. Furthermore, potential terrestrial applications of telemedicine and virtual medical avatars are discussed, highlighting the wider implications and benefits beyond space exploration. By leveraging advanced technologies and innovative approaches, telemedicine in conjunction with medical avatars offers a compelling avenue for enhancing healthcare practices both in space and on Earth.
Comparison of terrestrial exospheric hydrogen 3D distributions at solar minimum and maximum using TWINS Lyman-α observations
Authors: Zoennchen Jochen H. , Cucho-Padin Gonzalo , Waldrop Lara , Fahr Hans J.
Published: October 2024

Remote sensing observations of far-ultraviolet (FUV) emissions have been used to estimate 3D neutral hydrogen (H) density models of the terrestrial exosphere under solar minimum (2008) and solar maximum (2013 and 2015) conditions. Specifically, we used Lyman-alpha (Lyman-α, FUV at 121.6 nm) radiance data acquired by the Lyman-alpha detectors (LADs) onboard NASA’s TWINS satellites, collected over several days for each of the 3 years to provide sufficient coverage of the exospheric region. The datasets included Lyman-α measurements taken only above Earth radii (Re) of 3.75, assumed to be the optically thin region of the exosphere, where the measured Lyman-α intensity along a line of sight (LOS) is linearly proportional to the atomic hydrogen column density. Based on the calibration using multiple UV-bright stars, a significant decrease in TWINS1 LAD1/2 sensitivities was found for 2013 (LAD2 ∼1/2, LAD ∼1/3) and 2015 (LAD2 ∼1/3, LAD ∼1/7) compared to 2008. The calibration uncertainty was derived to be, on average, 5%. We estimated the 3D global hydrogen density distributions from these radiance data using two different tomographic inversion methods: first, a parametric fitting method based on a spherical harmonic function of order 3 and second, a high degree-of-freedom retrieval approach to validate our retrievals of H density. Both inversion methods consistently incorporate the effects of Lyman-α absorption within the exosphere and Lyman-α re-emission from Earth’s albedo. Our results reveal that H densities during solar maximum conditions are, on average, 30%–40% higher than those during solar minimum. All models showed a high concentration of atomic H on the dayside and nightside near the Sun–Earth line, which determines a nose/geotail structure consistent with theoretical effects from the solar radiation pressure. Furthermore, we identified that H-density enhancements during solar maximum with respect to solar minimum conditions occur at mid-to-high latitudes, particularly on the dusk side, while no significant enhancement seems to occur near the dayside nose.
The impact of socialisation services in the whole process of agricultural production on food security—quasi-natural experimental evidence from China
Authors: Tao Ying , Zhao Cuiping
Published: October 2024

Food security (FS) is an important guarantee for world peace and development and the basis for building a community of human destiny, which has a bearing on the sustainable development and future destiny of humankind. This study empirically analysis the relationship between socialisation services in the whole process of agricultural production (ASS) and guaranteeing FS, as well as the path of their role, using provincial panel data from 2010 to 2022 in China as an example, using the double-difference method. The regression results show that ASS can have the ability to contribute to the level of FS, and the conclusion still holds after a series of robustness tests. The results of the heterogeneity analysis show that the role of ASS in guaranteeing FS receives the influence of the level of agricultural development in each region, while it plays a greater role in the main food-producing areas. The mechanism analysis analyses the mechanism of the role of ASS in the whole process of agricultural production in guaranteeing FS from the three links of pre-production, mid-production and post-production respectively, and finds that ASS in the whole process of agricultural production is able to guarantee FS by reducing the cost of purchasing means of production in the pre-production stage, fostering a new type of agricultural management main body in the mid-production stage, and increasing the income of farmers’ household management in the post-production stage. Based on the above findings, this study proposes corresponding policy recommendations. This study can provide insights for ensuring world FS and contribute to maintaining social stability and development. The conclusions of the study are universally applicable, and all countries in the world can benefit from and draw lessons from it.
Trends in Healthy Life Years Between 2005 and 2019 in 31 European Countries: The Compression or Expansion of Morbidity?
Authors: Straka Jakub , Šídlo Luděk , Kulhánová Ivana
Published: October 2024

Objectives

Our objective was to assess morbidity trends in Europe and to classify European countries based on population ageing theories: the compression, expansion and dynamic equilibrium of morbidity.

Methods

The proportions of healthy life years were calculated for 31 European countries for the period 2005–2019 based on life expectancy values and healthy life years at age 65 years adopted from the Eurostat database. European countries were classified according to morbidity patterns applying the standard deviation distance from the average of relative change method between the selected years.

Results

A large degree of variation in terms of life expectancy and healthy life years at age 65 years was determined between 2005 and 2019. While the life expectancy differences between men and women were consistent across all the European countries, the gender gap concerning healthy life years was more diverse. Approximately one-third of the countries fell into the expansion, compression and dynamic equilibrium categories, respectively.

Conclusion

Significant variations were identified in healthy life year trends across European countries, which underscores the need for preventive strategies.
“You Scare Me”: The Effects of Humanoid Robot Appearance, Emotion, and Interaction Skills on Uncanny Valley Phenomenon
Authors: Berns Karsten , Ashok Ashita
Published: October 2024

This study investigates the effects of humanoid robot appearance, emotional expression, and interaction skills on the uncanny valley phenomenon among university students using the social humanoid robot (SHR) Ameca. Two fundamental studies were conducted within a university setting: Study 1 assessed student expectations of SHRs in a hallway environment, emphasizing the need for robots to integrate seamlessly and engage effectively in social interactions; Study 2 compared the humanlikeness of three humanoid robots, ROMAN, ROBIN, and EMAH (employing the EMAH robotic system implemented on Ameca). The initial findings from corridor interactions highlighted a diverse range of human responses, from engagement and curiosity to indifference and unease. Additionally, the online survey revealed significant insights into expected non-verbal communication skills, continuous learning, and comfort levels during hallway conversations with robots. Notably, certain humanoid robots evoked stronger emotional reactions, hinting at varying degrees of humanlikeness and the influence of interaction quality. The EMAH system was frequently ranked as most humanlike before the study, while post-study perceptions indicated a shift, with EMAH and ROMAN showing significant changes in perceived humanlikeness, suggesting a re-evaluation by participants influenced by their interactive experiences. This research advances our understanding of the uncanny valley phenomenon and the role of humanoid design in enhancing human–robot interaction, marking the first direct comparison between the most advanced, humanlike research robots.
ADRC Control of Ultra-High-Speed Electric Air Compressor Considering Excitation Observation
Authors: Zhou Jiaming , Li Yingzheng , Zhang Jinming , Yi Fengyan , Feng Chunxiao , Zhang Caizhi , Deng Bo , Qi Honglei , Wang Yu , Wang Shuo
Published: October 2024

With the increasing power of fuel cells, ultra-high-speed electric air compressors (UHSEACs) have been widely used. However, due to the ultra-high speeds involved, UHSEACs face problems such as long speed adjustment times and large speed fluctuations. Compared to other control methods, Active Disturbance Rejection Control (ADRC) is well-suited for highly nonlinear systems like UHSEACs. The Extended State Observer (ESO), a key component of the ADRC, struggles to accurately observe high-frequency excitations. To address this, the first step is to add a cascaded structure to the ESO and design a Current State Extended State Observer (CS-ESO) to better observe the electromagnetic and load excitations in the UHSEAC. The second step involves designing the ADRC based on the CS-ESO and performing speed adjustment simulations. The third step is to build a UHSEAC experimental platform and a conduct speed adjustment experiment. The findings indicate that, compared to the Proportional Integral Derivative (PID) control, the ADRC with the ESO, and the Sliding Mode Control (SMC), the use of the ADRC with the CS-ESO results in a significant reduction in overshoot—by at least 760 RPM under load-increasing conditions and 140 RPM under load-reducing conditions. Furthermore, the speed regulation time is notably decreased by at least 0.2 s and 0.1 s under these respective conditions.
Assessing the Principle of Equitable Access versus Non-Appropriation in the Era of Mega-Constellations
Authors: Yang Kuan , Amongin Sandra
Published: October 2024

In the 21st century, mega-constellations and interconnected satellite constellations deployed at various orbital altitudes, such as LEO, MEO, and GEO, with low Earth orbits (LEOs) being the most commonly used, have emerged as a trend, aiming to enhance the productivity and reduce the costs in space service delivery. The UNOOSA has noted the uncertainty in the exact number of satellites but conducted simulations based on a substantial sample, projecting a significant increase from the 2075 satellites recorded in orbit in 2018. This surge in the launch of mega-constellations poses profound challenges to existing international space laws, originally formulated with limited consideration for private space actors, who are increasingly engaging in space activities, particularly with the cost-effective utilization of mega-constellations. This study critically analyzes the compatibility of mega-constellations with the current international space laws by examining the applicability of mega-constellations concerning equitable access and the non-appropriation principle, addressing their potential occupation of substantial orbital spaces during activities, and analyzing whether the acquisition of orbital slot licenses violates these two principles. Following an in-depth analysis, this study proposes recommendations to amend the existing laws, aiming to resolve ambiguities and address emerging challenges. Recognizing the time-consuming process of amending international space laws, this study suggests practical recommendations for supplementary rules of the road, prompting reflection on the potential obsolescence of the current international space laws in the face of evolving space activities.
Effects of Non-Uniform Center-Flow Distribution and Cavitation on Continuous-Type Pintle Injectors
Authors: Choi Dongwoo , Lee Seunghyeon , Ahn Kyubok
Published: October 2024

In this paper, the flow characteristics of a continuous-type liquid–liquid pintle injector are described, focusing on the differential impact of a non-uniform center-flow distribution on single- and bi-injection methodologies as well as the cavitation effect on the spray angle. Using cold-flow experiments, jet-type flows of the center propellant caused by a non-uniform flow distribution were observed during a single injection. This resulted in an augmented pressure drop, as opposed to the flow characteristics of uniform single-film injection. By contrast, bi-injection modalities exhibited a substantial reduction in the pressure drop of the center propellant, underscoring a more equitable flow distribution. Moreover, the occurrence of cavitation in the center propellant was found to markedly affect the spray angle. By considering the injection exit area reduction caused by cavitation, the spray-angle prediction accuracy increased. The findings of this study are expected to reveal the interplay between flow distribution and pressure drop as well as that between cavitation and the spray angle in pintle injectors. Through this understanding, this study provides crucial considerations for the development of more efficient propulsion systems.
Precision Manufacturing in China of Replication Mandrels for Ni-Based Monolithic Wolter-I X-ray Mirror Mandrels
Authors: Xue Jiadai , Wang Bo , Liao Qiuyan , Wu Kaiji , Liu Yutao , Wu Yangong , Chen Wentao , Qiao Zheng , Jin Yuan , Ding Fei , Wang Dianlong , Wang Langping , Li Guo , Yang Yanji , Chen Yong
Published: October 2024

The X-ray satellite “Einstein Probe” of the Chinese Academy of Sciences (CAS) was successfully launched on 9 January 2024 at 15:03 Beijing Time from the Xichang Satellite Launch Center in China with a “Long March-2C” rocket. The Einstein Probe is equipped with two scientific X-ray telescopes. One is the Wide-field X-ray Telescope (WXT), which uses lobster-eye optics. The other is the Follow-up X-ray Telescope (FXT), a Wolter-I type telescope. These telescopes are designed to study the universe for high-energy X-rays associated with transient high-energy phenomena. The FXT consists of two modules based on 54 thin X-ray Wolter-I grazing incidence Ni-replicated mirrors produced by the Italian Media Lario company, as contributions from the European Space Agency and the Max Planck Institute for Extraterrestrial Physics (MPE), which also provided the focal-plane detectors. Meanwhile, the Institute of High Energy Physics (IHEP), together with the Harbin Institute of Technology and Xi’an Institute of Optics and Precision Mechanics, has also completed the development and production of the structural and thermal model (STM), qualification model (QM) and flight model (FM) of FXT mirrors for the Einstein Probe (EP) satellites for demonstration purposes. This paper introduces the precision manufacturing adopted in China of Wolter-I X-ray mirror mandrels similar to those used for the EP-FXT payload. Moreover, the adopted electroformed nickel replication process, based on a chemical nickel–phosphorus alloy, is reported. The final results show that the surface of the produced mandrels after demolding and the internal surface of the mirrors have been super polished to the roughness level better than 0.3 nm RMS and the surface accuracy is better than 0.2 μm, and the mirror angular resolution for single mirror shells may be as good as 17.3 arcsec HPD (Half Power Diameter), 198 arcsec W90 (90% Energy Width) @1.49 keV (Al-K line). These results demonstrate the reliability and advancement of the process. As the first efficient X-ray-focusing optics manufacturing chain established in China, we successfully developed the first focusing mirror prototype that could be used for future X-ray satellite payloads.