bluuebunny/crossref_metadata_2025 huggingface dataset:
Marinobufagenin, Left Ventricular Hypertrophy and Residual Renal Function in Kidney Transplant Recipients
Authors: Bolignano Davide , Greco Marta , Presta Pierangela , Caglioti Alfredo , Carullo Nazareno , Zicarelli Mariateresa , Foti Daniela Patrizia , Dragone Francesco , Andreucci Michele , Coppolino Giuseppe
Published: April 2023

Background: Left ventricular hypertrophy (LVH), which is a pervasive complication of end-stage kidney disease (ESKD), persists in some uremic individuals even after kidney transplantation (Ktx), contributing to worsening CV outcomes. Marinobufagenin (MBG), an endogenous steroid cardiotonic hormone endowed with natriuretic and vasoconstrictive properties, is an acknowledged trigger of uremic cardiomyopathy. However, its clinical significance in the setting of Ktx remains undefined. Methods: In a cohort of chronic Ktx recipients (n = 40), we assessed circulating MBG together with a thorough clinical and echocardiographic examination. Forty matched haemodialysis (HD) patients and thirty healthy subjects served as controls for MBG measurements. Patients were then prospectively followed up to 12 months and the occurrence of an established cardio-renal endpoint (death, CV events, renal events, graft rejection) was recorded. Results: Median MBG plasma levels were lower in Ktx as compared with HD patients (p = 0.02), but higher as compared with healthy controls (p = 0.0005). Urinary sodium (β = 0.423; p = 0.01) and eGFR (β = −0.324; p = 0.02) were the sole independent predictors of MBG in this cohort, while a strong correlation with left ventricular mass index (LVMi), found in univariate analyses (R = 0.543; p = 0.0007), gained significance only in multivariate models not including eGFR. Logistic regression analyses indicated MBG as a significant predictor of the combined endpoint (OR 2.38 [1.10–5.12] per each 1 nmoL/L increase; p = 0.01), as well as eGFR, LVMi, serum phosphate and proteinuria. Conclusions: Ktx recipients display altered MBG levels which are influenced by sodium balance, renal impairment and the severity of LVH. Thus, MBG might represent an important missing link between reduced graft function and pathological cardiac remodelling and may hold important prognostic value for improving cardio-renal risk assessment.
The Ability to Look Beyond: The Treatment of Peripheral Arterial Disease
Authors: Sirignano Pasqualino , Margheritini Costanza , Ruggiero Federica , Panzano Claudia , Filippi Federico , Rizzo Luigi , Taurino Maurizio
Published: April 2023

This paper offers a practical overview of the contemporary management of patients with peripheral arterial disease presenting intermittent claudication (IC), including clinical and instrumental diagnosis, risk factors modification, medical management, and evidence-based revascularization indications and techniques. Decision making represents a crucial element in the management of the patient with IC; for this, we think a review of this type could be very useful, especially for non-vascular specialists.
The Effects of Methylfolate on Cognitive Decline and Dementia: A Protocol for Systematic Review and Meta-Analysis
Authors: Prado Leícia Iris de Assunção , Junger Ana Lúcia , Caixeta Leonardo Ferreira , Noll Matias , Oliveira Cesar de , Silveira Érika Aparecida
Published: April 2023

Introduction: Dementia and cognitive decline are highly prevalent in later life and are growing public health concerns worldwide due to the increasing aging population. Individuals diagnosed with dementia have reduced mental function, resulting in social and cognitive skill deficits, increased dependence, and reduced autonomy—all of which are conditions associated with higher mortality rates. This systematic review aims to assess the effectiveness of treating dementia and cognitive decline with methylfolate. The main outcomes analyzed will be dementia and changes in cognitive function measured by different instruments in older adults treated with methylfolate. Secondary outcomes, such as inflammatory markers, plasma folic-acid levels, and total homocysteine, will also be assessed. Methods and Analysis: This study will be carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This protocol is registered in the International Prospective Registry of Systematic Reviews, under the code CRD42021275755. We will include clinical trials conducted with older adults diagnosed with dementia or cognitive decline and treated with folic acid. The searches will be conducted on the PubMed, Scopus, and Embase databases, and the articles will be selected by reading their titles and abstracts first, followed by the full text. The quality of the selected studies will be assessed using GRADE and the risk of bias will be assessed using the Downs-and-Black method. Ethics and Dissemination: The results will be presented at scientific conferences and disseminated by publishing a scientific article in an international English-language journal. We hope to find robust and significant evidence regarding the effectiveness of methylfolate supplementation in improving dementia symptoms and cognitive decline among older adults. By systematizing this evidence and possibly performing a meta-analysis study, we expect to significantly contribute to the treatment of this health problem, reduce mortality, and improve the quality of life and health of this population, boosting the development of medical protocols capable of reducing the financial effects of public health.
Ferrite Shield to Enhance the Performance of Optically Pumped Magnetometers for Fetal Magnetocardiography
Authors: Tardelli Gabriela P. , Phan Tan , Strasburger Janette , Baffa Oswaldo , Wakai Ronald
Published: April 2023

Fetal magnetocardiography (fMCG) has proven to be an important tool for the prenatal monitoring of electrical cardiac activity; however, the high cost of superconducting quantum instrumentation (SQUID) poses a limitation for the dissemination of fMCG as a routine clinical technique. Recently, optically pumped magnetometers (OPMs) operating within person-sized, cylindrical shields have made fMCG more practical, but environmental magnetic interference entering through the shield opening substantially degrades the quality of fMCG signals. The goal of this study was to further attenuate these interferences by placing the OPM array within a small ferrite shield. FMCG recordings were made with and without the ferrite shield in ten subjects inside a person-sized, three-layer mu-metal cylindrical shield. Although the fetal signal was slightly attenuated, the environmental interference was reduced substantially, and maternal interference was also diminished. This increased the signal-to-noise ratio significantly and improved the resolution of the smaller waveform components. The performance improvement was highest in the axial direction and compensated for a major weakness of open-ended, person-sized shields. The ferrite shield is especially beneficial for the deployment of triaxial OPM sensors, which require effective shielding in all directions.
Inconsistencies in Pregnant Mothers’ Attitudes and Willingness to Donate Umbilical Cord Stem Cells: A Cross-Sectional Analysis from Saudi Arabia
Authors: AL-Shammary Asma Ayyed , Hassan Sehar un-Nisa
Published: April 2023

The collection and storage of umbilical cord stem cells (UCSCs) have a crucial role in improving and expanding stem cell-based therapies, which are becoming popular in Saudi Arabia and other Middle East countries. Many patients and families in Saudi Arabia depend on private cord banks in foreign countries to purchase stem cells, which has financial and medical implications. The current study aims at determining the predictors of current registration status and willingness to donate cord blood stem cells among expectant mothers in Saudi Arabia. A cross-sectional study collected data from 714 expectant mothers from all thirteen regions of Saudi Arabia in December 2022. The online survey questionnaire assessed women’s awareness, direct and indirect exposure to stem-cell therapy, sources of knowledge, willingness, reluctance, and current registration status to donate cord blood. Although women demonstrated higher acceptance and lower rejection towards the donation of UCSCs, just one percent (n = 7; 1%) of expectant mothers in this sample are registered with the Saudi Stem Cell Registry. Overall, 48% indicated their willingness to register in the future. Both correlational analysis and multiple regression analysis demonstrated that awareness significantly predicted willingness to donate (p < 0.01), and rejection attitudes were negatively related to willingness to donate (p < 0.001). Although the mean scores on acceptance were high, they were not found to be significantly associated with willingness to donate. Prior direct and indirect exposure to stem cell therapy appeared to be the strongest predictor of pregnant women’s willingness to register (p < 0.001). Findings suggest that acceptance attitudes do not have a symmetrical relationship with intention. Women’s prior exposure to stem cell therapy was the most significant factor; therefore, findings demonstrate that currently women are relying on their firsthand experience to decide about cord blood donation rather than the information obtained from other sources, such as social media and the internet. Though attitudes were not identified as significant predictors in the statistical models, awareness was a relevant factor, and the findings signify increasing awareness in various target populations to enhance the probability of intention to donate cord stem cells.
Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network
Authors: Han Ji Eun , Park Min Kyu , Jin Ju Hyun , Lee Jung Ah , Park Gyeongsin , Park Jong Sook , Bae Han-Ik , Yun Seok Joong , Seo An Na , Han Man-Hoon , Lee Hyoungnam , Jeon Jae-Pil , Yu Ji-In , Kim Soon Sun , Cheong Jae Youn
Published: April 2023

A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored biobanks are affiliated with the Korea Biobank Network (KBN), for which the National Biobank of Korea plays a central coordinating role among KBN biobanks. KBN organized several working groups to address new challenges and needs in biobanking. The “Normal Healthy Control Working Group” developed standardized criteria for three defined control groups, namely, normal, normal-plus, and disease-specific controls. Based on the consensus on the definition of a normal control, we applied the criteria for normal control participants to retrospective data. The main reason for exclusion from the “Normal-plus” group was blood test results beyond 5% of the reference range, including hypercholesterolemia. Subclassification of samples of normal controls by detailed criteria will help researchers select optimal normal controls for their studies.
Lung Ultrasound in the Evaluation of Lung Disease Severity in Children with Clinically Stable Cystic Fibrosis: A Prospective Cross-Sectional Study
Authors: Jaworska Joanna , Buda Natalia , Kwaśniewicz Piotr , Komorowska-Piotrowska Anna , Sands Dorota
Published: April 2023

With the increasing longevity of cystic fibrosis (CF), there is a growing need to minimise exposure to ionising radiation in patients who undergo regular imaging tests while monitoring the course of the lung disease. This study aimed to define the role of lung ultrasounds (LUS) in the evaluation of lung disease severity in children with clinically stable CF. LUS was performed on 131 patients aged 5 weeks to 18 years (study group) and in 32 healthy children of an equivalent age range (control group). Additionally, an interobserver study was performed on 38 patients from the study group. In CF patients, the following ultrasound signs were identified: I-lines; Z-lines; single, numerous and confluent B-lines; Am-lines; small and major consolidations; pleural line abnormalities and small amounts of pleural fluid. The obtained results were evaluated against an original ultrasound score. LUS results were correlated with the results of chest X-ray (CXR) [very high], pulmonary function tests (PFTs) [high] and microbiological status [significant]. The interobserver study showed very good agreement between investigators. We conclude that LUS is a useful test in the evaluation of CF lung disease severity compared to routinely used methods. With appropriate standardisation, LUS is highly reproducible.
Accuracy between 2D Photography and Dual-Structured Light 3D Facial Scanner for Facial Anthropometry: A Clinical Study
Authors: Cascos Rocío , Ortiz del Amo Laura , Álvarez-Guzmán Francisco , Antonaya-Martín José Luis , Celemín-Viñuela Alicia , Gómez-Costa Diego , Zafra-Vallejo Mónica , Agustín-Panadero Rubén , Gómez-Polo Miguel
Published: April 2023

(1) Background: Facial scanners are used in different fields of dentistry to digitalize the soft tissues of the patient’s face. The development of technology has allowed the patient to have a 3-dimensional virtual representation, facilitating facial integration in the diagnosis and treatment plan. However, the accuracy of the facial scanner and the obtaining of better results with respect to the manual or two-dimensional (2D) method are questionable. The objective of this clinical trial was to evaluate the usefulness and accuracy of the 3D method (a dual-structured light facial scanner) and compare it with the 2D method (photography) to obtain facial analysis in the maximum intercuspation position and smile position. (2) Methods: A total of 60 participants were included, and nine facial landmarks and five interlandmarks distances were determined by two independent calibrated operators for each participant. All measurements were made using three methods: the manual method (manual measurement), the 2D method (photography), and the 3D method (facial scanner). All clinical and lighting conditions, as well as the specific parameters of each method, were standardized and controlled. The facial interlandmark distances were made by using a digital caliper, a 2D software program (Adobe Photoshop, version 21.0.2), and a 3D software program (Meshlab, version 2020.12), respectively. The data were analyzed by SPSS statistical software. The Kolmogorov–Smirnov test revealed that trueness and precision values were normally distributed (p > 0.05), so a Student’s t-test was employed. (3) Results: Statistically significant differences (p ≤ 0.01) were observed in all interlandmark measurements in the 2D group (photography) to compare with the manual group. The 2D method obtained a mean accuracy value of 2.09 (±3.38) and 2.494 (±3.67) in maximum intercuspation and smile, respectively. On the other hand, the 3D method (facial scanner) obtained a mean accuracy value of 0.61 (±1.65) and 0.28 (±2.03) in maximum intercuspation and smile, respectively. There were no statistically significant differences with the manual method. (4) Conclusions: The employed technique demonstrated that it influences the accuracy of facial records. The 3D method reported acceptable accuracy values, while the 2D method showed discrepancies over the clinically acceptable limits.
Diagnostic Value of the Sentinel Lymph Node Technique in Patients with Muscle-Invasive Bladder Cancer
Authors: Małkiewicz Bartosz , Jędrzejuk Diana , Gurwin Adam , Wilk Karol , Knecht-Gurwin Klaudia , Kiełb Paweł , Krajewski Wojciech , Bolanowski Marek , Hałoń Agnieszka , Szydełko Tomasz
Published: April 2023

Background: The optimal limits of the bilateral pelvic lymph node dissection (PLND) template in bladder cancer treatment remain controversial. This study aimed to investigate whether radio-guided sentinel node (SLN) detection is a reliable technique for the perioperative localisation of potential lymphatic metastasis during cystectomy for muscle-invasive bladder cancer (MIBC). Materials and Methods: We studied 54 patients with pT2-pT4 MIBC who underwent cystectomy with extended PLND (ePLND) augmented by the SLN technique. The identification of SLN was performed by preoperative SPECT/CT hybrid lymphoscintigraphy using peritumoral injection of nanocolloid-Tc-99m, followed by intraoperative navigation with a handheld γ-probe. All nodal specimens were collected separately and then fixed in formalin, stained with haematoxylin and eosin, and examined by an experienced uropathologist. Results: A total of 1414 LNs were resected and examined for the presence of metastases. The mean number of harvested LNs was 26 (range: 11–50) per patient. In 51 of 54 patients, 192 SLNs were resected. In addition, 20/192 (10.4%) SLNs were located outside of the ePLND area. Overall, 72 metastatic LNs (LN+) were found in 22 of 54 patients (40.7%) and in 24/192 SLNs (12.5%). The SLN technique detected LN+ in 14 of 22 (64%) patients. The SLNs were the only sites of metastasis (SLN+ = LN+) in 6 of 22 (27.3%) LN+ patients, including two cases with foci located in the pararectal region. The diagnostic values for the sensitivity, specificity, positive predictive value, and false-negative rate for the SLN technique were 66.66%, 4.16%, 28.57%, and 33.33%, respectively. Extended lymphadenectomy and its combination with the SLN technique enabled the correct assessment in 96.3 and 100% of patients, respectively. Conclusions: The combination of ePLND and SLN provides a better pN assessment compared to ePLND alone. Although the SLN technique has restrictions that limit its diagnostic value, its use as an addition to lymphadenectomy allows for the visualisation of nonstandard lymph drainage pathways that may be potential metastatic routes.
Intramural Hematoma of Gastrointestinal Tract in People with Hemophilia A and B
Authors: Teng Wei-Jung , Kung Ching-Huei , Cheng Mei-Mei , Tsai Jia-Ruey , Chang Chia-Yau
Published: April 2023

People with hemophilia (PWH), especially severe hemophilia, often experience bleeding episodes, which occur mostly at major joints. Intramural hematoma of the gastrointestinal (GI) tract is a rare, potentially life-threatening clinical bleeding manifestation in PWH. Prompt identification and timely administration of clotting factor concentrates are of utmost importance for effective management and optimal patient outcomes. In this report, we present the case of a 48-year-old male with severe hemophilia A. The patient developed a spontaneous intramural hematoma of the jejunum, leading to signs of acute abdomen, bloody stool, and paralytic ileus. Conservative management with factor VIII (FVIII) infusion was successfully administered. However, within a span of three months, the patient suffered from a recurrent episode of intramural hematoma, which was again effectively treated with conservative therapy. Subsequently, prophylactic FVIII therapy was administered to the patient, resulting in the absence of recurrence for over three years. Inspired by this case, we conducted a comprehensive review of the relevant literature and gathered data from 79 reported cases of intramural hematoma that were documented between the years 1956 and 2022. We classified these cases based on the site affected within the gastrointestinal (GI) tract (spread across five different locations) and proceeded to conduct a simple pooling analysis on the data collected, which subsequently revealed that the overall mortality rate of intramural hematoma in people with hemophilia (PWH) was found to be 12.2%, while children have a higher mortality rate (23.3%) than adults (4.9%). We hope this case report and literature review increase awareness of this rare bleeding manifestation in PWH, the effectiveness of conservative treatment, and the possibility of prophylaxis against recurrence.
Risk-Benefit of IBD Drugs: A Physicians and Patients Survey
Authors: D’Amico Ferdinando , Vieujean Sophie , Caron Benedicte , Peyrin-Biroulet Laurent , Danese Silvio
Published: April 2023

Background: Treatment choices for patients with inflammatory bowel disease (IBD) are based on the balance between risks and benefits. Our AI was to compare the perspectives of patients and physicians in evaluating the risks and benefits before initiating therapy for IBD. Methods: An anonymous survey was conducted between March and August 2022. All patients with confirmed IBD and all physicians who attended an IBDscope webinar were invited to participate. Results: In total, 367 patients and 146 physicians participated. For most patients (71.4%) and physicians (89.0%), efficacy and safety were equally important. Clinical improvement and clinical remission were the most relevant outcomes for patients (90.9 and 88.4), while clinical remission and endoscopic remission were for physicians (90.0 and 87.6). The main factors in the benefit-risk assessment were quality of life (95.1%), disease activity (87.5%), and presence of comorbidities (84.5%) for patients, and presence of comorbidities (99.3%), disease activity (97.9%), and prior failure to biologics/small molecules (96.6%) for physicians. Based on patients’ and physicians’ opinions, the risk of serious infections, malignancies, cardiovascular events, death, relapse, all infections, surgery, and hospitalization should be included in the benefit-risk assessment. Conclusion: Physicians and patients have different priorities in evaluating the benefit-risk balance of a new therapy.
Submicron-Grooved Films Modulate the Directional Alignment and Biological Function of Schwann Cells
Authors: Zhang Zhen , Lv Yuanliang , Harati Javad , Song Jianan , Du Ping , Ou Peiyan , Liang Jiaqi , Wang Huaiyu , Wang Peng-Yuan
Published: April 2023

Topographical cues on material surfaces are crucial for guiding the behavior of nerve cells and facilitating the repair of peripheral nerve defects. Previously, micron-grooved surfaces have shown great potential in controlling nerve cell alignment for studying the behavior and functions of those cells and peripheral nerve regeneration. However, the effects of smaller-sized topographical cues, such as those in the submicron- and nano-scales, on Schwann cell behavior remain poorly understood. In this study, four different submicron-grooved polystyrene films (800/400, 800/100, 400/400, and 400/100) were fabricated to study the behavior, gene expression, and membrane potential of Schwann cells. The results showed that all submicron-grooved films could guide the cell alignment and cytoskeleton in a groove depth-dependent manner. Cell proliferation and cell cycle assays revealed that there was no significant difference between the submicron groove samples and the flat control. However, the submicron grooves can direct the migration of cells and upregulate the expression of critical genes in axon regeneration and myelination (e.g., MBP and Smad6). Finally, the membrane potential of the Schwann cells was significantly altered on the grooved sample. In conclusion, this study sheds light on the role of submicron-grooved patterns in regulating the behavior and function of Schwann cells, which provides unique insights for the development of implants for peripheral nerve regeneration.
Buck-Boost Charge Pump Based DC-DC Converter
Authors: Keramida Evi , Souliotis George , Vlassis Spyridon , Plessas Fotis
Published: April 2023

This paper presents a novel inductorless dual-mode buck-boost charge pump (CP) based DC-DC converter. The proposed architecture allows the same circuit to accomplish two modes of operation, buck and boost, for degrading or elevating the output voltage, respectively, compared to the input. To achieve each mode, only a switching of the input–output connections is needed without any other modification in the design of the DC-DC converter. The dual-mode configuration aims to merge two different functions into one circuit, minimizing the design time and the area the DC-DC converter occupies on the die. The proposed buck-boost CP has been designed using TSMC 65 nm complementary metal–oxide–semiconductor (CMOS) technology. The functional input voltage range of the CP in boost mode is 1.2 V to 1.8 V and the typical output voltage is 1.8 V. For the buck mode, the input voltage range is 3.2 V to 3.6 V and the output is 1.5 V. For both modes, the output can be easily modified to new values by changing the comparator configuration. Efficiency results are also provided for the two modes.
Finding Nemo’s Giant Cousin: Keypoint Matching for Robust Re-Identification of Giant Sunfish
Authors: Pedersen Malte , Nyegaard Marianne , Moeslund Thomas B.
Published: April 2023

The Giant Sunfish (Mola alexandrini) has unique patterns on its body, which allow for individual identification. By continuously gathering and matching images, it is possible to monitor and track individuals across location and time. However, matching images manually is a tedious and time-consuming task. To automate the process, we propose a pipeline based on finding and matching keypoints between image pairs. We evaluate our pipeline with four different keypoint descriptors, namely ORB, SIFT, RootSIFT, and SuperPoint, and demonstrate that the number of matching keypoints between a pair of images is a strong indicator for the likelihood that they contain the same individual. The best results are obtained with RootSIFT, which achieves an mAP of 75.91% on our test dataset (TinyMola+) without training or fine-tuning any parts of the pipeline. Furthermore, we show that the pipeline generalizes to other domains, such as re-identification of seals and cows. Lastly, we discuss the impracticality of a ranking-based output for real-life tasks and propose an alternative approach by viewing re-identification as a binary classification. We show that the pipeline can be easily modified with minimal fine-tuning to provide a binary output with a precision of 98% and recall of 44% on the TinyMola+ dataset, which basically eliminates the need for time-consuming manual verification on nearly half the dataset.
Experimental Study on the Effect of the Blade Tip Distance on the Power and the Wake Recovery with Small Multi-Rotor Wind Turbines
Authors: Gong Sen , Pan Kai , Yang Hua , Yang Junwei
Published: April 2023

In order to investigate the output power and wake velocity of small multi-rotor wind turbines compared to single-rotor wind turbines, which operate in the same swept area at various blade tip distances, this paper used the wind tunnel test method to examine single-rotor wind turbines with diameter D of 0.4 m and 0.34 m corresponding to the triple-rotor wind turbines and double-rotor wind turbines with a single rotor diameter D of 0.24 m, respectively. The experimental results indicated that, without rotation speed control, the triple-rotor wind turbine produced more power than the single-rotor wind turbine with an equivalent swept area and that the output power tended to rise initially and then fall as the distance between each rotor increased. Moreover, the power increase reached a maximum of 8.4% at the 0.4D blade tip distance. In terms of wake measurement, triple-rotor wind turbines had smaller wake losses and faster recovery rates than single-rotor wind turbines. The smaller the blade tip distance, the earlier the wake merged and fused and the faster the recovery rate. In designing small multi-rotor wind turbines, the above discussion can serve as a guide.
An Iterative Re-Optimization Framework for the Dynamic Scheduling of Crossover Yard Cranes with Uncertain Delivery Sequences
Authors: Wang Yao-Zong , Hu Zhi-Hua
Published: April 2023

In yard-crane scheduling problems, as loading operations take priority over unloading, the delivery sequence of unloading from the quaysides to the yard is uncertain. The delivery sequence changes may make crane scheduling more difficult. As a result, the crane operations schedules developed statically become suboptimal or even infeasible. In this paper, we propose a dynamic scheduling problem considering uncertain delivery sequences. A mixed-integer linear program is developed to assign tasks to cranes and minimize the makespan of crane operations. We propose an iterative solution framework in which the schedules are re-optimized whenever the delivery sequence change is revealed. A genetic algorithm is proposed to solve the problem, and a greedy algorithm is designed to re-optimize and update the solution. To make the updated solution take effect as soon as possible, regarding batch-based task assignment, the tasks in the scheduling period are divided into several batches. In this case, the instant requests arising from the delivery sequence change are added to corresponding batch tasks and re-optimized together with the tasks of this batch. In addition, a relaxation model is formulated to derive a lower bound for demonstrating the performance of the proposed algorithm. Experimental results show that the average gap between the algorithm and the lower bound does not exceed 5%. The greedy insertion algorithm can re-optimize the instant requests in time. Therefore, the proposed iterative re-optimization framework is feasible and has the advantages (necessity) of batch-based task assignment.
Assemblage Distribution of the Larval and Juvenile Myctophid Fish in the Kuroshio Extension Region: Winter 2020
Authors: Xu Hao , Liu Bilin , Cao Yangming
Published: April 2023

Myctophids are an ecologically important mesopelagic species in the eastern Pacific Ocean. Due to the wide distribution, great diversity and variable biological characteristics of the species, there is a lack of reliable information regarding their spawning and nursery grounds in the Kuroshio extension region. In this study, we identified a total of 110 myctophid individuals using DNA barcoding and morphological techniques, among which, the dominant genus was Ceratoscopelus, comprising 37.27% of the entire catch. The abundance of each sampling station was calculated, and its relationship with environmental variables was analyzed. Tweedie-Generalized Additive Model (GAM) analysis showed that copepod density, oceanic dynamic processes, and sea surface temperature were the primary factors influencing the distribution pattern of larvae and juvenile myctophid fish. The results further indicate that the Kuroshio extension plays a dominant role in the biological processes of these fish in this region. These findings provide crucial dynamic information for the scientific conservation and exploitation of myctophids, which could have significant implications for the management of these fish populations.
A Multi-Task Learning for Submarine Cable Magnetic Anomaly Recognition
Authors: Liu Yutao , Wu Yuquan , Yang Lei , Zhou Puzhi , Kuang Jianxun , Yu Wenjie , Wang Jianqiang , Xu Zhe , Li Gang
Published: April 2023

The recognition of submarine cable magnetic anomaly (SCMA) signals is a challenging task in magnetic signal data processing. In this study, a multi-task convolutional neural network (MTCNN) model is proposed to simultaneously recognize abnormal signals and locate abnormal regions. The residual block is added to the shared feature backbone to improve the ability of the network to extract high-level features and maintain the gradient stability of the model in the training process. The long short-term memory (LSTM) block is added to the classification branch task to learn the internal relationship of the magnetic anomaly time series, so as to improve the network’s ability to recognize magnetic anomalies. Our proposed model can accurately recognize the SCMA signals collected in the East China Sea and the South China Sea. The classification accuracy and the ability to locate the abnormal regions are close to the manual labeling of human analysts. The newly developed model can help analysts reduce the probability of missing and misjudging submarine cable magnetic anomalies, improve the efficiency and accuracy of interpretation, and could even be deployed to an unmanned platform to realize the automatic detection of SCMAs.
Ship Dynamics and Hydrodynamics
Authors: Sutulo Serge , Guedes Soares C.
Published: April 2023

Ship hydrodynamics and dynamics is a rather old, traditional branch of applied mechanics and also of naval architecture [...]
New Routines in Making the Local News: How Fear and Distancing Change the Coverage of Violence in Brazil
Authors: Reis Aline Grupillo
Published: April 2023

The purpose of this article is to discuss to what extent the coverage of urban violence by local television news in Brazil has been impacted by journalists’ fear and their distancing from regions of armed conflict, leading to the development of new professional routines and, in particular, the use of WhatsApp. Our methodology included in-depth interviews with 13 journalists occupying different positions in the hierarchy of the newsrooms of the 4 main TV stations in the country. The testimonies suggest that aggression and hostility against journalists drove professionals away from certain territories and turned them toward new technologies and citizen co-production as ways out for local crime coverage. On the other hand, this dynamic creates challenges for journalism itself. One of the main concerns is the verification of content.
Do you Hear what I Hear? A Qualitative Study Examining Psychological Associations Underlying Evaluations of Everyday Sounds in Patients with Chronic Tinnitus
Authors: Baniotopoulou Christina , Boecking Benjamin , Mazurek Birgit
Published: April 2023

Tinnitus is a multifactorial phenomenon and psychological, audiological, or medical factors can facilitate its onset or maintenance. A growing body of research investigates individuals’ perceptions, associations, and experiences of living with tinnitus. This body of research examines tinnitus as a condition rather than a symptom. We examine a sample of chronic tinnitus patients in terms of associations that are induced by neutral sounds. In particular, we investigate how patients with chronic tinnitus ascribe meaning to those neutral sounds. The present study uses Mayring’s content analysis to explore the content of psychological associations underlying valence ratings of everyday neutral sounds. Nine tinnitus patients completed a hearing exercise, during which they listened to seven neutral sounds, following which we examined their sound-induced associations using semi-structured interviews. Three groups of factors influenced patients’ associations and valence ratings of neutral sounds: affect, episodic memory, and ‘other’. The former two factors further comprised two subcategories. In line with previous psychoaudiological research designs, our findings suggest that neutral, everyday auditory stimuli evoke strong affective reactions—possibly through serving as retrieval cues for episodic memories. Based on these findings, we discuss our results in the context of previous psychoaudiological findings and propose further research concerning psychological associations that may specifically underlie the tinnitus sound.
Bortezomib Pharmacogenetic Biomarkers for the Treatment of Multiple Myeloma: Review and Future Perspectives
Authors: Sanz-Solas Antonio , Labrador Jorge , Alcaraz Raquel , Cuevas Beatriz , Vinuesa Raquel , Cuevas María Victoria , Saiz-Rodríguez Miriam
Published: April 2023

Multiple myeloma (MM) is a hematological neoplasm for which different chemotherapy treatments are used with several drugs in combination. One of the most frequently used drugs for the treatment of MM is the proteasome inhibitor bortezomib. Patients treated with bortezomib are at increased risk for thrombocytopenia, neutropenia, gastrointestinal toxicities, peripheral neuropathy, infection, and fatigue. This drug is almost entirely metabolized by cytochrome CYP450 isoenzymes and transported by the efflux pump P-glycoprotein. Genes encoding both enzymes and transporters involved in the bortezomib pharmacokinetic pathway are highly polymorphic. The response to bortezomib and the incidence of adverse drug reactions (ADRs) vary among patients, which could be due to interindividual variations in these possible pharmacogenetic biomarkers. In this review, we compiled all pharmacogenetic information relevant to the treatment of MM with bortezomib. In addition, we discuss possible future perspectives and the analysis of potential pharmacogenetic markers that could influence the incidence of ADR and the toxicity of bortezomib. It would be a milestone in the field of targeted therapy for MM to relate potential biomarkers to the various effects of bortezomib on patients.
SARS-CoV-2 Footprints in the Placenta: What We Know after Three Years of the Pandemic
Authors: Tosto Valentina , Meyyazhagan Arun , Alqasem Malek , Tsibizova Valentina , Di Renzo Gian Carlo
Published: April 2023

As the COVID-19 pandemic continues into its third year, there is accumulating evidence on the consequences of maternal infection. Emerging data indicate increased obstetrics risks, including maternal complications, preterm births, impaired intrauterine fetal growth, hypertensive disorders, stillbirth, gestational diabetes, and a risk of developmental defects in neonates. Overall, controversial concerns still exist regarding the potential for vertical transmission. Histopathological examination of the placenta can represent a useful instrument for investigation and can contribute significant information regarding the possible immunohistopathological mechanisms involved in developing unfavorable perinatal outcomes. Based on current evidence, SARS-CoV-2 infection can affect placental tissue by inducing several specific changes. The level of placental involvement is considered one of the determining factors for unfavorable outcomes during pregnancy due to inflammation and vascular injuries contributing to complex cascade immunological and biological events; however, available evidence does not indicate a strong and absolute correlation between maternal infection, placental lesions, and obstetric outcomes. As existing studies are still limited, we further explore the placenta at three different levels, using histology, immunohistochemistry, and molecular genetics to understand the epidemiological and virological changes observed in the ongoing pandemic.
Kidney Health and Care: Current Status, Challenges, and Developments
Authors: Lin Ming-Yen , Chiu Yi-Wen , Lin Yu-Hsuan , Kang Yihuang , Wu Ping-Hsun , Chen Jeng-Huei , Luh Hsing , Hwang Shang-Jyh ,   on behalf of the iH3 Research Group
Published: April 2023

The concept of chronic kidney disease (CKD) originated in the 2000s, and an estimated 850 million patients are currently suffering from health threats from different degrees of CKD. However, it is unclear whether the existing CKD care systems are optimal for improving patient prognosis and outcomes, so this review summarizes the burden, existing care models, effectiveness, challenges, and developments of CKD care. Even under the general care principles, there are still significant gaps in our understanding of the causes of CKD, prevention or care resources, and care burdens between countries worldwide. Receiving care from multidisciplinary teams rather than only a nephrologist shows potential profits in comprehensive and preferable outcomes. In addition, we propose a novel CKD care structure that combines modern technologies, biosensors, longitudinal data visualization, machine learning algorithms, and mobile care. The novel care structure could simultaneously change the care process, significantly reduce human contact, and make the vulnerable population less likely to be exposed to infectious diseases such as COVID-19. The information offered should be beneficial, allowing us to rethink future CKD care models and applications to reach the goals of health equality and sustainability.
Navigation Guided Biopsy Is as Effective as Frame-Based Stereotactic Biopsy
Authors: Lim Dae Hyun , Kim So Yeon , Na Young Cheol , Cho Jin Mo
Published: April 2023

Background: Stereotactic biopsy is a standard procedure for brain biopsy. However, with advances in technology, navigation-guided brain biopsy has become a well-established alternative. Previous studies have shown that frameless stereotactic brain biopsy is as effective and safe as frame-based stereotactic brain biopsy is. In this study, the authors evaluate the diagnostic yield and complication rate of frameless intracranial biopsy. Materials and Methods: We reviewed data from biopsy performed patients between March 2014 and April 2022. We retrospectively reviewed medical records, including imaging studies. Various intracerebral lesions were biopsied. Diagnostic yield and post-operative complications were compared with those of frame-based stereotactic biopsy. Results: Forty-two frameless navigation-guided biopsy were performed, and the most common pathology was primary central nervous system lymphoma (35.7%), followed by glioblastoma (33.3%), and anaplastic astrocytomas (16.7%), respectively. The diagnostic yield was 100%. Post-operative intracerebral hematoma occurred in 2.4% of cases, but it was not symptomatic. Thirty patients underwent frame-based stereotactic biopsy, and the diagnostic yield was 96.7%. There was no difference in diagnostic rates between two methods (Fisher’s exact test, p = 0.916). Conclusions: Frameless navigation-guided biopsy is as effective as frame-based stereotactic biopsy is, without causing further complications. We consider that frame-based stereotactic biopsy is no longer needed if frameless navigation-guided biopsy is used. A further study will be needed to generalize our results.
Bosworth Fractures of the Ankle: A Systematic Literature Review
Authors: Lucenti Ludovico , Testa Gianluca , Nocera Chiara , Culmone Annalisa , Dell’Agli Eleonora , Pavone Vito
Published: April 2023

Bosworth lesions are fracture-dislocations of the ankle and are characterized by entrapment of the proximal segment of the fibula behind the posterior tubercle of the distal tibia. Treatment is challenging, mainly due to failure of a closed reduction. The aim of this study was to review the literature concerning this type of injury. A total of 103 patients with Bosworth fractures were included in the study. The analyzed studies yielded a total of 103 cases, of which 68% (n = 70) were male and 32% (n = 33) were female. Bosworth fractures are mainly due to accidental trauma (58.2%), sports-related injuries (18.4%), and traffic accidents (18.4%). More than 76% of the patients presented a Danis–Weber B fracture, 8.7% a type C fracture, and only 0.97% presented a type A fracture. In 92.2% of the patients, the attempted closed reduction was unsuccessful. A definitive treatment with open reduction and internal fixation (ORIF) was used in 96 patients (93.2%). The most frequent complication was post-traumatic arthritis (10.7%). Bosworth fractures are challenging. The available literature lacks adequate information about this fracture, and an approved standardized algorithm for treating such fractures is not available.
Concurrent Diagnosis of Adenomyosis and Congenital Uterine Anomalies: A Review
Authors: Feghali Edwin , Etrusco Andrea , Haydamous Joe , Ayed Amal , Laganà Antonio Simone , Chiantera Vito , Vitale Salvatore Giovanni , Angioni Stefano , Stabile Guglielmo , Sleiman Zaki
Published: April 2023

Background: Adenomyosis and congenital uterine anomalies (CUAs) can compromise reproductive potential and may coexist in the same patient, especially in cases of infertility. This review (CRD42022382850) aims to evaluate the published cases of concurrent adenomyosis and syndromic and nonsyndromic CUAs. Methods: A literature search for suitable articles published in the English language was performed using the following databases from inception to 30 November 2022: MEDLINE, EMBASE, Global Health, the Cochrane Library, Health Technology Assessment Database, and Web of Science. Articles including both CUAs and adenomyosis, with data about their potential relationship, were included. Results: The literature search retrieved 14 articles that met the purpose of this review and summarized the most recent findings regarding the concurrent diagnosis of adenomyosis and CUAs. Conclusions: Adenomyosis can be found in both syndromic and nonsyndromic CUAs, and may arise from several etiologies. The hypothesis that obstructions in CUAs increase uterine pressure and promote the development of adenomyosis remains to be further elucidated, and additional findings may also play a role. The patient’s genetic, epigenetic, and hormonal patterns, as well as normal physiological processes, such as pregnancy, may influence the growth of adenomyosis.
An Event Study on the Reaction of Equity and Commodity Markets to the Onset of the Russia–Ukraine Conflict
Authors: Obi Pat , Waweru Freshia , Nyangu Moses
Published: April 2023

Using a standard event study methodology and the EGARCH model, this study examined the depth of market anomaly at the onset of the Russia–Ukraine conflict in 2022. Equity markets in Africa and G7 nations were analyzed for their varied political and economic connections to the conflict. While the G7 nations were strongly opposed to Russia, African countries remained neutral. This study shows that abnormal losses in the initial period of the conflict were larger and more persistent in the G7 markets, contradicting the widely held notion that more developed equity markets are more efficient than the less developed markets. EGARCH results revealed that volatility persistence was widely present, although the leverage effect was only confirmed for U.S. and Canada. Throughout the period, commodity prices rose sharply, producing significant abnormal gains in the futures market. Unfortunately, this had a deleterious effect on African economies due to their heavy reliance on grain and fuel imports, all of which are priced in U.S. dollars, and which also rose sharply during the period. This study concludes with suggestions on how to mitigate currency and commodity price shocks to dollar-reliant and import-dependent economies.
Research on Informatization Level, Technological Innovation and Urban Environmental Pollution: A Quasi-Natural Experiment Based on the Next-Generation Internet Demonstration City Policy
Authors: Li Bo , Xu Xiangmiao
Published: April 2023

This study uses the data of 280 Chinese prefecture-level cities from 2008 to 2019 as the research samples, and the DID (difference-in-difference) model to explore the negative impact of the Next-Generation Internet Demonstration City Policy (NGIDCP) on urban environmental pollution, and further analyzes the transmission mechanisms of informatization level and technological innovation in this influence. The results show that the NGIDCP can effectively reduce urban environmental pollution, and the conclusion still holds after various robustness tests. The informatization level and technological innovation have some mechanism effects on the impact of the NGIDCP on urban environmental pollution. The results of the regional heterogeneity test show that the negative impact of the NGIDCP on urban environmental pollution is significant in the eastern and western regions and has little effect on the central region. At the end of the paper, some recommendations on urban environmental pollution based on the conclusions drawn from the study are proposed.