bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Parstatin Promotes Angiogenesis and Ameliorates Left Ventricular Dysfunction during Pressure Overload
Authors:   Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY-40202, USA, Givvimani Srikanth , Narayanan Nithya , Pushpakumar Sathnur Basappa , Tyagi Suresh C.
Published: September 2023

Parstatin, a novel protease activated receptor-1 (PAR-1) derived peptide is a potent inhibitor of angiogenesis. We and others have reported that imbalance between angiogenic growth factors and anti-angiogenic factors results in transition from compensatory cardiac hypertrophy to heart failure in a pressure overload condition. Though cardio protective role of parstatin was shown previously in ischemic cardiac injury, its role in pressure overload cardiac injury is yet to unveil. We hypothesize that supplementing anti-parstatin antibody during pressure overload condition augments angiogenesis and ameliorate left ventricular dysfunction and heart failure. To verify this, we created ascending aortic banding in mice to mimic pressure overload condition and then treated mice with anti-parstatin antibody. Left ventricular function was assessed by echocardiography and pressure-volume loop study. Angiogenic growth factors and anti-angiogenic factors along with MMP-2,-9 were evaluated by western blot and immunohistochemistry. Results: our results showed an improved left ventricular function in anti-parstatin treated aortic banding hearts compared to their corresponding wild type controls. Expression of angiogenic growth factor, VEGF, MMP-2 and CD31 expression was increased in treated aortic banding hearts compared to their corresponding wild type controls. Our results suggest that treating pressure overload mice with anti-parstatin antibody augments angiogenesis and ameliorates left ventricular dysfunction.
The Protective Effect of Stauntonia Chinensis Polysaccharide on CCl4-induced Acute Liver Injuries in Mice
Authors:   School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei, China, Yan Shirong , Yang Jiaojiao , Xiong Qingming , Zhang Jing , Zhu Lihua , Zhu Bo ,   First Clinical College, Hubei University of Medicine, Shiyan, Hubei, China
Published: September 2023

Objective: To investigate the protective effect of Stauntonia chinensis polysaccharides (SCP) on carbon tetrachloride (CCl4) induced acute liver injuries in mice. Methods: Kunming mice were randomly divided into three groups: the control group, the pathological model group, and the SCP group. The SCP group was further divided into three subgroups based on SCP treatment: Low dosage (50 mg/kg), medium dosage (100 mg/kg) and high dosage (200 mg/kg). After being fed for 7 days, mixed-edible-oil solution was intraperitoneally injected into the control group, while the other two groups were injected with 0.15% CCl4 mixed with mixed-edible-oil. Sera were collected from mice 24 h later to determine the activity of serum alanine transaminase (ALT). Mice were then sacrificed to prepare liver homogenate. Levels of liver malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and nitric oxide (NO) were determined. Pathological changes in livers were also analyzed. Results: SCP significantly reduced the ALT activity in the serum and inhibited the decrease of serum GSH, GSH-PX and SOD and rose the levels of MDA and NO (P<0.05-0.01). This lessened the pathological damage to the liver tissues. Conclusion: SCP protects against CCl4-induced acute liver injuries in mice.
Topical Delivery of Vitamin D3: A Randomized Controlled Pilot Study
Authors:   College of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia, Sadat-Ali Mir , Bubshait Dalal A. , Al-Turki Haifa A. , Al-Dakheel Dakheel A. , Al-Olayani Wissam S.
Published: September 2023

Background and Objective: The purpose of the present study is to explore the assessment if the transdermal delivery of vitamin D is feasible. Methods: In 50 female Medical students, this study was conducted. Age, weight and height was taken, a detailed history and clinical examination was performed. Blood was drawn for 25 Hydroxy Vitamin D3 (25OHD) level. Two women had >30 ng/mL of 25OHD and was excluded from the study. The participants were divided into two groups of 24 in each arm. All participants equivocally agreed not to change their dietary habits and life style till the study was over. The study group of women were asked to apply; Top-D (Aloe Vera based- Vitamin D3) (Patency Pending) was developed at King Fahd Hospital of the University, AlKhobar with each gram of the Top-D cream delivering 5000 IU of vitamin D3. The second group used 1 gram of Aloe vera gel. The participants had no knowledge to which group they belong. A second blood sample was taken at the end of 3 months and the data was analyzed. Results: The data of 48 women was available for analysis. The average age was 22.58 ± 1.95 years. The mean pre-treatment 25OHD in the study group was 12.05 ng/Ml ± 6.54 and post-treatment was 37.95 ng/mL ± 6.43 (P=0.001, CI<28.582 ). In control group pre-treatment 25OHD was 11.4 ng/mL ± 3.97 and post-treatment was 10.58ng/mL ± 3.03. Conclusions: This randomized control study shows that vitamin D3 can safely be delivered through the dermal route. This route could be exploited in treating vitamin D deficiency.
Pigmented Basal Cell Carcinoma of Nipple and Areola in a Male Breast - A Case Report with Review of Literature
Authors:   ESIC Medical College & PGIMSR, Bangalore, India, Kalyani R. , Vani B. R. , Srinivas Murthy V. , Veda P.
Published: September 2023

Basal cell carcinoma is a common skin cancer worldwide. However basal cell carcinoma of nipple and areola complex is rare, commonly seen in males in elderly age group. The tumor has aggressive behavior with increased tendency for metastasis. We present a case in a 78 year male in the left breast.
Topical "Soft Candle" Applications for Infected Diabetic Foot Wounds: A Cause for Concern?
Authors:   Department of Clinical Surgical Sciences, University of the West Indies, St. Augustine Campus, Trinidad and Tobago, West Indies, Cawich Shamir O. , Harnarayan Patrick , Islam Shariful ,   Department of Surgery, San Fernando General Hospital, Trinidad & Tobago, West Indies, Bobb Nahmorah J. , Ramsewak Shivaa , Budhooram Steve , Ramdass Michael J. , Naraynsingh Vijay ,   Department of Clinical Surgical Sciences, University of the West Indies, St. Augustine Campus, Trinidad and Tobago, West Indies
Published: September 2023

Aims: There is a cultural barrier to early medical intervention for diabetic foot infections in Trinidad & Tobago, stemming from the strong cultural belief in "soft candle" as effective treatment. We carried out a case-control study to evaluate the outcomes of "soft candle" to treat diabetic foot infections. Methods: All consecutive patients admitted with diabetic foot infections were interviewed to collect data on: demographics, medical history, unhealthy lifestyle markers (exposure to risk factors for chronic diseases), chosen treatment and details of "soft candle" use. The hospital records were accessed on discharge to records the main outcome measures: HbA1c readings, duration of hospitalization, amputation and in-hospital mortality. Two groups were defined: The control group included patients who sought medical attention after detecting a foot infection. The study group included patients who recognized their infection but voluntarily chose to utilize "soft candle" regimens. We excluded patients who voluntarily chose to use other forms of non-traditional treatment or sought no treatment at all. Outcomes were compared using SPSS ver 19. A two-tailed P value was calculated for variables of interest in each group using Fisher's exact test. The duration of hospitalization between the groups was compared using paired T-Test. A P value <0.05 was considered statistically significant. Results: There were 442 patients who met inclusion criteria: There were 60 patients in the study group at an average age of 55.2 years (SD ± 11.4; range 43-88): 63% had HBA1c readings >7.0% at presentation and 95% had unhealthy lifestyle habits. There were 382 patients in the control group at an average age of 59.1 years (SD ± 12.6, Range 37-89): 74% with HBA1c readings >7.0% at presentation and 48% with unhealthy lifestyle habits. Patients who used “soft candle” had significantly longer duration of hospitalization (15.5 ± 10.2 vs 9.2 ± 3.9 days; P<0.001) and major amputations (13.3% vs 5.6%; P=0.048) that was considered clinically significant. There was no difference in minor amputations (31.7% vs 34.3%; P=0.770) or in-hospital mortality (1.7% vs 0.52%; P=0.355) between the groups. Conclusion: In its current form, the traditional practice of topical “soft candle” application to diabetic foot wounds may be potentially harmful. Persons with diabetes should be warned about these effects. We have identified the target population for educational campaigns.
A Comparative Study of Serum Uric Acid levels and Lipid Ratios in Coronary Artery Disease Patients
Authors:   Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India, Sathiya R. , Amirtha Ganesh B. ,   Department of Cardiology, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India, Velu V. Kuzhandai , Niranjan G. , Srinivasan A. R. , Ramesh R. , Babu M. Sathish , Saha Subiman ,   Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV), Pillaiyarkuppam, Puducherry, India
Published: September 2023

Introduction:Coronary Artery Disease (CAD) appears to be common in the Indian population of different geographical origins, religions and languages. Measurement of lipid fractions and ratios are widely recommended for risk assessment. A few studies have shown that serum uric acid plays a role in the development of cardiovascular morbidity. Very few reports are cited linking serum uric acid with the lipid fraction in CAD. Objectives:To find the significance of non-HDL cholesterol, LDL-c/HDL-c ratio, TC/HDL ratio and serum uric acid level in CAD patients. Subjects and Methodology:In this study, we included fifty CAD patients as subjects and an equal number of controls. Both subjects and controls were assessed for anthropometric, physiological and biochemical parameters. Results:The present study showed significant increased levels of total cholesterol (p=0.002), TAGs (p<0.001), HDL (p=0.005), LDL (p<0.006) and non-HDL cholesterol (p<0.001). LDL-c/HDL-c ratio (p<0.001) and TC/HDL ratio (p<0.001) in CAD patients (subjects) were also significant when compared to controls. Uric acid level in CAD patients was increased (p<0.001). Conclusion:Serum Uric Acid, TC/HDL and LDL/HDL ratios could be regarded as objective markers, in association with existing atherogenic dyslipidemia in patients with CAD.
Vulval Fibroadenoma - A Report of Two Cases with Review of Literature
Authors:   Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore, Karnataka, India, Kalyani R. , Srinivas Murthy V. , Veda P.
Published: September 2023

Vulval fibroadenoma is rare benign tumours arising from ectopic breast tissue or mammary like anogenital glands tissue. Only a few cases are reported in medical literature. It is usually seen between 20 – 80 years of age. Excision usually has good prognosis and rarely recurs. We present two cases of vulval fibroadenoma, one in a 26 years woman as a well defined soft tissue mass in right labia major and other in a 45 years woman as a pedunculated soft tissue mass in left labia major.
Lovastatin Inhibits Low Molecular Weight Hyaluronan Induced Chemokine Expression via LFA-1 and Decreases Bleomycin-Induced Pulmonary Fibrosis
Authors:   University of Kansas Hospital, USA, Hamblin Mark J. , Eberlein Michael ,   University of Iowa, Iowa City, IA, USA, Black Katharine ,   Massachusetts General Hospital, Boston, MA, USA, Hallowell Robert , Collins Samuel , Chan-Li Yee , Horton Maureen R. ,   Johns Hopkins University School of Medicine, Baltimore, MD, USA
Published: September 2023

BACKGROUND: Lovastatin has a unique ability to bind Leukocyte Function Antigen-1 (LFA-1), an integrin necessary for the full expression of inflammatory cytokines induced by the low molecular weight form of the extracellular matrix glycosaminoglycan hyaluronan (LMW HA). We hypothesized that lovastatin could inhibit LMW HA inflammatory signals via interaction with LFA-1, and attenuate bleomycin induced pulmonary fibrosis. METHODS: We evaluated the effects of lovastatin, pravastatin, LFA-1 blocking antibodies, and a novel LFA-1 inhibitor LFA 878 on LMW HA induced cytokine production in alveolar macrophages. We evaluated the effect of lovastatin in a bleomycin model of lung injury. RESULTS: Lovastatin immediately inhibited the LMW HA induced cytokine MIP 1-α (p=0.001) independent of HMG CoA reductase. Pravastatin showed no inhibitory profile when administered simultaneously with LMW HA. LFA-1 blocking antibodies and the small molecule statin derivative LFA 878 showed an inhibitory profile similar to lovastatin. Lovastatin showed decreased fibrosis on histopathology and improved survival at day 14, with a decrease in fibrocytes noted at day 8. CONCLUSION: Lovastatin and LFA 878 inhibit LMW HA inflammatory signaling independent of HMG-CoA decreasing the chemotactic cytokine MIP 1-α. Lovastatin treatment improves survival in bleomycin lung injury with decreased fibrocytes and fibrosis.
Assessment of Pharmacokinetics and Toxicology of Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) in Rats and Goats
Authors:   Department of Orthopaedic Surgery, University of Dammam, Saudi Arabia, Al-Habdan Ibrahim , Alghamdy Mastour Safar , Randhawa Akram ,   Department of Pharmacology, University of Dammam, Saudi Arabia, Chathoth Shahanas ,   Prince Mohammed bin Fahd Centre for Research and Consultation Studies, University of Dammam, Saudi Arabia, Sadat-Ali Mir ,   Department of Orthopaedic Surgery, University of Dammam, Saudi Arabia
Published: September 2023

Background: Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) was discovered and patented with USPTO in 2008. Studies have shown that SHMSP works as an angiogenesis factor. This study was done to evaluate pharmacokinetics (PK) in rats and toxicology studies in goats and rats. Methods: In 80 skeletally mature Sprague Dawley rats 5 milligram/kg body weight of SHMSP was injected intramuscularly. Blood samples were collected at 0, 30, 60, 120, 240, 320 minutes and 480 minutes. The plasma calibration curves were prepared at concentrations of 6.25, 3.12, 1.56, 0.78 and 0.39 ng/mL by spiking 190 µL of rat plasma with 10µL of working standard and 200 µL of deionized water. Samples were vortexed for five seconds, centrifuged at 14000 rpm for 30 minutes at 4°C and the supernatant was collected analyzed using High-performance liquid chromatography (HPLC). After injection of 20 µL sample, the peptide was eluted with 15ml linear gradient up to 36% of eluent A. The time between injections was 25 min. and the eluent was monitored at a wavelength of 215 nm. The concentration of peptide present in the rat plasma samples collected at different time intervals were quantified using standard curve method. The goats were injected deep intramuscularly 100 mg/kg-body weight of the SHMSP dissolved in injection solution. In 10 Sprague Dawley rats of ≥250 grams of weight, 20 mg/kg/day SHMSP was injected for 7 consecutive days. All the animals were kept at a close watch. Clinical observation at least once daily and as necessary was undertaken. After 2 weeks animals were euthanized and major organs were harvested and histopathology samples were obtained and processed. Results: There were no deaths is either of the study and control group of animals. The gross observations of the various organs appeared normal and histopathological studies did not show any toxicity in the organs tested. The plasma concentration-time profile of SHMSP after intramuscular injection, the level of SHMSP in an initial high phase reaching the highest at 30 minutes 2.3184 ng/ml and 60 minutes 1.7447 ng/ml at 60 minutes. The lowest level was at 360 minutes of 0.0879 ng/ml. Conclusions: The dose of SHMSP at 20 times the recommended dose was not toxic and secondly the peak time and level was at 30 minutes to 120 minutes and the plasma half-life of SHMSP was 90 minutes.
Immuno-Modulator Metallo-Peptide Reduces Inflammatory State in Obese Zucker Fa/Fa Rats
Authors:   Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Cuernavaca 62210, Morelos, Mexico, Gomez-Solis Antonieta , Garcia-Vazquez Francisco ,   Instituto Nacional de Pediatia, Mexico city 04530, Mexico, Reyes-Esparza Jorge , Alvarez-Ayala Elizabeth , Rodriguez-Fragoso Lourdes ,   Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Cuernavaca 62210, Morelos, Mexico
Published: September 2023

Metabolic syndrome is a prothrombotic and proinflammatory chronic state. In obesity, the adipose tissue secretes various adipokines that take part in a variety of physiological and pathophysiological processes, including immunity and inflammation. Previous studies using a liver damage model treated with the immune-modulator metallo-peptide (IMMP) showed lessening in the degree of inflammation. Therefore, this study was set up to evaluate the anti-inflammatory effect of IMMP in obese Zucker fa/fa rats. We used Zucker-Lepr fa/fa and Zucker-Lean in this protocol. The groups received IMMP 50 ng/kg by i.p., three times per week for 8 weeks. Blood samples were collected by cardiac puncture and the serum was preserved at -80°C until analysis; the liver was excised and preserved in formaldehyde 4%. Analyses were performed to determine cytokine, insulin, glucose, triglyceride and cholesterol levels in serum, and histological analysis was also performed. IMMP treatment of obese rats resulted in decreased levels of proinflammatory cytokines (leptin, lL-6, IL-1betha, INF-gamma) and a chemokine (MCP-1), and increased levels of anti-inflammatory adipokine (adiponectin). In addition, treatment decreased the damage and hepatic steatosis generated in the tissue of obese rats. The IMMP exerted an anti-inflammatory effect in obese rats and therefore may be an effective and safe therapeutic alternative in the treatment of metabolic syndrome.
Potential Beneficial Effects of Si-Wu-Tang on White Blood Cell Numbers and the Gastrointestinal Tract of γ-Ray Irradiated Mice
Authors:   Current Address: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China, Ni Jin , Romero-Weaver Ana L. , Kennedy Ann R. ,   Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
Published: September 2023

Si-Wu-Tang (SWT) is a decoction consisting of a mixture of ingredients of Rehmanniae Radix, Angelica Radix, Chuanxiong Rhizoma and Paeoniae Radix. As a traditional Chinese herbal decoction, SWT has been widely used for the treatment of diseases characterized as blood and/or energy deficit. The present study was performed to evaluate the effects of SWT on the different populations of circulating white blood cells (WBCs) and gastrointestinal changes in γ-ray irradiated mice. Female mice were treated daily with orally administered SWT seven days before irradiation, until one day before irradiation or until one day before sample collection. WBC counts were determined from peripheral blood samples taken from the mice at different times post-irradiation. Hematoxylin and eosin (H&E) staining, as well as immunohistochemical analysis of fibrinogen, were utilized to evaluate the effects of SWT in the intestines of mice after radiation exposure. The results of the present studies demonstrate that SWT has protective effects against radiation damage to circulating WBCs, specifically to lymphocytes, and to the gastrointestinal tract of the irradiated animals.
Determination of the Frequency of Second Mesiobuccal Canal in Permanent Maxillary First Molar Teeth with Magnification Loupes (×3.5)
Authors:   Dental Section, Department of Surgery, Aga University Hospital, Karachi, Pakistan, Hasan Muhammad , Khan Farhan Raza
Published: September 2023

introduction: The mesiobuccal root of the maxillary first molar has generated more research and clinical investigation than any root. An inability to detect and treat a second mesiobuccal (MB2) canal is a reason for endodontic failure in maxillary first molars. Modifications in the endodontic access and detection techniques, along with advancements in illumination and magnification technology, have aided in the location and treatment with the second mesiobuccal canal of maxillary first molars. OBJECTIVE: To determine the frequency of the second mesiobuccal canal in the permanent maxillary first molars with magnification loupes (× 3.5). materialS and methods: A total of 53 teeth were assessed using a moderate magnification for second mesiobuccal canal in mesiobuccal root of first permanent maxillary molars in vivo. Detection of this canal in maxillary first molars was done through a clinical access cavity preparation under magnification loupes (× 3.5). Data was analyzed using SPSS 15.0. Frequency distribution of variables was determined and the level of significance was kept at 0.05. RESULTS: We were able to detect second mesiobuccal canal in 27 out of 53 (50.9%) of the permanent maxillary first molars that were studied. It was found that the males tend to have a higher proportion of second mesiobuccal canals (up to 31%) as compared to the females in whom the second mesiobuccal canals could be identified only 19% of the time. Whilst, there was no association found between age, gender and chamber obliteration with the presence of second mesiobuccal canal. CONCLUSIONS: In conclusion, within its limitations, this study suggested that the use of magnification loupes enhanced both the detection (50.9%) and negotiation (86.8%) of the second mesiobuccal canals in the permanent maxillary first molars beyond what could be achieved with naked eye.
Acute Amiodarone Pulmonary Toxicity Following Lung Resection
Authors:   Department of Medicine, Reading Health System, West Reading, PA, USA, Fadahunsi Opeyemi , Krol Ronald ,   Division of Pulmonary and Critical Care, Reading Health System, West Reading, PA, USA
Published: September 2023

Amiodarone is one of the most frequently prescribed antiarrhythmic agents. Despite its widespread use, it is associated with systemic side effects. Pulmonary toxicity, the most severe adverse effect of amiodarone, has usually been described in the context of chronic amiodarone use. We report a case of an 80-year-old male presenting acutely following right upper lung lobe resection for stage 1b adenocarcinoma. He developed atrial fibrillation on postoperative day four and received 12.5 g of amiodarone within a 12 day period. On presentation, he had new bilateral lung opacities and a 35% absolute decline in the predicted diffusion capacity for carbon monoxide. Pulmonary embolism was ruled out on chest computed tomography. Amiodarone was discontinued and prednisone was initiated. Despite initial improvement, he suffered from multiple hypoxemic episodes until his death in the fourth month. In a subset of patients undergoing thoracic surgery who are intubated and require high levels of oxygen, the risk of amiodarone lung toxicity increases and patients may present acutely.
Serum Glucose and Malondialdehyde Levels in Alloxan Induced Diabetic Rats Supplemented with Methanolic Extract of Tacazzea Apiculata
Authors:   Department of Medical Laboratory Science, Bayero University Kano, PMB 3011, Kano, Nigeria, Gwarzo M. Y. , Ahmadu J. H. ,   National Biotechnology Development Agency, PMB 5118, Wuse-Abuja, Nigeria, Dikko A. U. A. ,   Department of Human Physiology Faculty of Medicine, Bayero University k Kano PMB 3011 Kano, Nigeria, Ahmad M. B. ,   Department of Medical Laboratory Science, Bayero University Kano, PMB 3011, Kano, Nigeria
Published: September 2023

Tacazzea apiculata is used by traditional medical practitioners for the treatment of wide range of diseases. The current work investigated the hypoglycemic and antioxidant properties of Tacazzea apiculata Oliv. on alloxan induced diabetes mellitus. Five groups (n=10) of rats were fed on commercial diet. The rats were divided into Group 1 (NUT) as non-diabetic and untreated, group 2 (NDT) as non-diabetic and treated, group 3 (DT) diabetic and treated. Group 4 (DUT) as diabetic and untreated. Group five (CP) were diabetic treated with Chlorpropamide, a drug used in the management of diabetic mellitus, with no known antioxidant property. Diabetic induction was done by intra-peritoneal injection of 100 mg/kg b. wt with alloxan. Fasting blood glucose was estimated seven days after induction to determine the severity of glucose elevation among the induced groups. Methanolic extract of T. apiculata leaf was administered to alloxan induced diabetic and non-diabetic control rats at 100mg/kg body weight for four weeks and blood glucose estimated on weekly basis. Malondialdehyde level was also estimated in the sera of the rats. Blood glucose level was monitored for additional 2 weeks post treatment. The results indicated that the extracts possess significant hypoglycemic effect on the diabetic rats (DT) having the mean glucose of (95.2 ± 9.12 mg/dl) compared to the diabetic untreated control group (DUT) with a mean glucose of (238.91 ± 4.42 mg/dl, p<0.05). The effect was sustained even on withdrawal of the extracts for two weeks. This was accompanied by a progressive increase in weight among all treated diabetic rats and non diabetic treated (DT and NDT) compared with diabetic untreated control rat (DUT) (p<0.05). A raised level in malondialdehyde was also observed among the diabetic rat prior to treatment and significantly decreased after the treatment. In conclusion the research demonstrated the hypoglycaemic and antioxidant potential of methanolic leaf extract of T. apiculata in alloxan induced rats.
HPLC-DAD Analysis and In-Vitro Property of Polyphenols Extracts from (Solanum Aethiopium) Fruits on A-Amylase, A -Glucosidase and Angiotensin - 1- Converting Enzyme Activities
Authors:   Department of Biochemistry, Federal University of Technology, P.M.B 704, Akure, 34001 Nigeria, Nwanna E. E. , Boligon A. A. , Athayde M. ,   Program of Post-Graduation in Pharmaceutical Sciences, Federal University of Santa Maria, Campus Camobi, CEP 97105-900, Brazil, Ibukun E. O. , Oboh G. , Ademosun A. O. ,   Department of Biochemistry, Federal University of Technology, P.M.B 704, Akure, 34001 Nigeria
Published: September 2023

AIM: Garden egg (Solanum aethiopium) is an edible fruits vegetable with different species.This study investigated characterisation and the effect of the phenolics extracts from S. aethiopium species with enzymes linked with type -2-diabetes (α-amylase and α-glucosidase) and hypertension [Angiotensin-1-converting enzyme (ACE)]. METHODS: Fresh samples of the 5 species of the garden egg namely, [Solanum gilo (PW), Solanum torvum (TWS), Solanum kumba (PGR), Solanum incanum (GSB), and Solanum indicum (WSB)] were oven-dried at 50°C and milled into flour. The aqueous extracts were prepared (1:50 w/v). The phenolic contents (total phenol and total flavonoid), vitamin C and 1,1-diphenyl–2-picrylhydrazyl (DPPH), the antioxidant activities of the extracts were evaluated. The ability of the extracts to inhibit diabetes enzymes in rat pancreas as well as the inhibition of angiotensin-1-converting (ACE) enzyme in lungs homogenates in vitro were investigated. Furthermore, the fruits polyphenols were identified and quantified using HPLC-DAD. RESULTS: The phenolic contents ranged from 2.70-3.76 mgGAE/g, while there were no significant (P>0.05) differences in their flavonoid content and ability to reduce Fe3+ to Fe2+. The vitamin C contents of the species ranged from 4.01-6.52 mg/ml. The extracts scavenged DPPH in a dose dependent manner with the IC50 values ranging from 3.23-4.20 mg/ml. Furthermore, the extracts showed strong inhibition of α-glucosidase, mild inhibition of α-amylase and strong inhibition of ACE activities. CONCLUSION: This study showed that the inhibition of the key enzymes relevant to type-2 diabetes and hypertension could be part of the mechanisms by which garden egg manage/prevent the degenerative conditions.
Unique Presentations of Invasive Lobular Breast Cancer: A Case Series
Authors:   Department of Internal Medicine, Baystate Medical Center (Tufts University School of Medicine), Springfield, MA, USA, Shakoor Muhammad Tariq , Ayub Samia ,   Department of Pulmonary and Critical Care, University of Arkansas for Medical Sciences, Little Rock, AR, USA, Mohindra Ramesh ,   Department of Hematology/Oncology, St Mary Mercy Hospital, Livonia, MI, USA, Ayub Zunaira ,   Medical Student, Fatima Jinnah Medical College, Lahore, Pakistan, Ahad Abdul ,   Medical Student, Nishter Medical College, Multan, Pakistan
Published: September 2023

Introduction: Breast carcinoma is the most common malignancy in women. Unlike IDC, which typically metastasizes to the lung, liver or bone, ILC has been found to metastasize to GI tract, peritoneum and retroperitoneum. Nonspecific symptomology may be considered secondary to other diseases and this can delay the definite diagnosis and treatment of metastatic disease. Knowledge of the pattern of disease spread is essential for accurate diagnosis and early initiation of systemic treatment, thus avoiding unnecessary interventions. We are reporting three unique cases of metastatic ILC presenting with wide range of symptoms. Case Presentations: Case A: 69-year-old female presented with recurrent jaundice. Case B: 77-year-old female with the past medical history of right breast ILC seven years ago status post right radical mastectomy with chemotherapy, presented with anemia. Case C: 56-year-old female presented with bright red blood per rectum. Conclusion: A high level of suspicion is needed for metastatic breast cancer in patients with history of ILC, regardless of disease free interval. Since it frequently metastasizes to unusual sites and presents with a wide spectrum of symptoms.
Percepción y actitud de los estudiantes de enfermería hacia la elaboración de tesis en la Universidad Privada San Juan Bautista 2022
Authors:   , Valverde Jara Diana Melissa
Published: September 2023

Introducción: La investigación es un método de aprendizaje fundamental que incita un pensamiento crítico, cual a través de su proceso se vitaliza y ayuda a la superación de cada estudiante de manera personal y profesional Objetivo: Determinar la percepción y actitud de los estudiantes del 8vo al 10 mo ciclo 2021-II de Enfermería hacia la elaboración de tesis en la Universidad Privada San Juan Bautista Chorrillos Lima 2022 Metodología: Estudio descriptivo de corte transversal. Participación en el estudio 138 estudiantes de Enfermería, se utilizó un instrumento ya validado, elaborado por Ochoa et al. Lima Perú, en el año 2016. Resultados: Se encontró que los estudiantes de Enfermería 78% tuvieron una percepción poco favorable, percepción favorable 10% y el 12% percepción desfavorable, en cuanto a sus dimensiones de enseñanza de la metodología de la investigación el 71% percepción poco favorable, en elaboración de proyecto de tesis un 82% poco favorable y en asesorías el 78% poco favorable. Para la actitud el 74% una actitud de indiferencia, el 17% de aceptación y el 9% de rechazo, y en su dimensión cognitiva el 71% actitud de indiferencia, dimensión afectiva el 75% actitud de indiferencia y en su dimensión conductual el 78% de indiferencia.
Riesgos laborales en el personal operario de la empresa Movitecnica S.A Chorrillos Lima 2022
Authors:   , Umpiri Yumbato Jose Luis
Published: September 2023

Introducción: El riesgo es una medida del peligro que se materializa en determinadas condiciones y genera daños a las personas, equipos y al ambiente que normalmente se califica en una escala que mide probabilidad, ocurrencias y niveles que determinan el actuar del empleador. Objetivo: Determinar los riesgos laborales en personal operario de la empresa Movitecnica S.A Chorrillos 2022. Metodología: Estudio de tipo cuantitativo, descriptivo de corte transversal. La población está conformada por 100 operarios, se trabajó con 80 operarios obtenidos por muestreo probabilístico, que reunieron criterios de inclusión y exclusión; la técnica utilizada fue una encuesta y como instrumento un cuestionario en escala Likert validado por la OSHA 2013, se realizó una prueba piloto para determinar la validez de criterio de coeficiente (R. de Pearson 0.47); asimismo, se determinó su confiabilidad a través del coeficiente alfa Cronbach (0.78). Resultados: Los riesgos laborales en el personal operario en forma global predomina el nivel medio con un 50%, en cada dimensión el nivel de riesgo fue medio. Riesgo mecánico 52%, riesgo físico 49%, riesgo ergonómico 85%el riesgo Psicosocial de 60%, sin embargo, en la dimensión riesgo químico predomina el nivel bajo un 50%.
Fundamentals of Artificial Intelligence and Machine Learning
Authors:   Department of Computer Science, School of Computing Sciences Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, India, A. Akila , R. Parameswari ,   Department of Computer Science, School of Computing Sciences Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, India., P. Sujatha ,   Department of Information Technology, School of Computing Sciences Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, India., R. Padma ,   Department of Computer Science, School of Computing Sciences Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, India.
Published: September 2023

With the development of new technologies, the ideas of Artificial Intelligence (AI) and Machine Learning (ML) have been put into practise for many years. It has become an integral part of our culture, permeating practically every aspect of our daily life, from formal education to leisure activities to mundane tasks and beyond. Specifically, it provides a more solid foundation for thinking about how technology affects our daily lives, which contributes to a more widespread appreciation of the themes to which it relates. Let us turn to science in hopes that it can inspire a transformation in our collective character. Let’s raise consciousness about the need of making technology accessible to everybody. Those in authority will then need to be briefed on the proper and improper use of the technology at the appropriate times. While going about our daily routines, we often find that discussions about artificial intelligence, robotics, and learning machines have become the norm
Pengaruh Kualitas Produk, Harga Dan Promosi Terhadap Keputusan Pembelian Tas Pada UD. Cindy Semarang
Authors: Agita Marsindi  , Sutopo Sutopo
Published: September 2023

Seiring dengan perkembangan dan kemajuan zaman mengakibatkan semakin ketatnya tingkat persaingan antar perusahaan. Persaingan yang ketat tidak hanya dilakukan oleh perusahaan dalam negeri saja, tetapi juga ditambah dengan banyaknya perusahaan asing yang masuk ke Indonesia. Oliver (2017) menjelaskan bahwa dalam era persaingan yang semakin ketat, salah satu cara untuk meningkatkan daya saing suatu perusahaan adalah dengan menghadirkan produk yang mempunyai kualitas tinggi serta mampu memenuhi keinginan konsumen, harga yang terjangkau, dan promosi yang menarik.
Advertising: in search of a definition. A critical review
Authors:   Faculty of Journalism and Mass Communication, Vangelov Nikola
Published: September 2023

Advertising is a term that most people have heard and are basically aware of what it means. However, theory and practice have constantly been making attempts at defining it throughout the years of its theoretical existence. Like society, advertising has also evolved. So has its definition. It is mainly due to its constant efforts to adapt to the ever-changing human needs and desires. Of course, the term is just a word and it would not have been able to progress had it not been for the constant efforts of practitioners and theorists. The methodology uses content analysis to outline some of the most distinguished definitions of the term. In particular, it examines two studies by Jef Richards, which use the Delphi method to reach a plausible definition. In the end, the author comprises a working definition that generalizes the key elements of advertising while proposing a new understanding of some.
Corporate and Media Image. Social Responsibility as a Challenge for Their Building
Authors:   Faculty of Journalism and Mass Communication, Kandeva Ina
Published: September 2023

The image of a company is a complex factor that depends on a number of socio-psychological and, to a large extent, economic and managerial prerequisites. At the basis of all this is good corporate communication and building a positive media image. For the corporate image to be built, complete and functioning, a number of factors must be taken into account, one of which is the company‘s social responsibility. This article aims to strengthen the hypothesis that social commitment and corporate responsibility of a company are essential for building a good corporate image. An author‘s empirical research using the closed-type survey method is presented, in which the respondents‘ attitudes towards various factors that influence the construction of a positive corporate and media image are examined.
The political metaphors for the war in Ukraine in the morning block of NOVA TV “Hello, Bulgaria” through the prism of ideological discourse
Authors:   Faculty of Journalism and Mass Communication, Aneva Nаdelina
Published: September 2023

Metaphors play a bigger role in our lives than we realize. Our system of thinking and acting is metaphorical, as argued by George Lakoff and Mark Johnsen. In this article, the war in Ukraine, reflected in the Bulgarian media, in particular in Nova TV, is considered as a system of conceptual metaphors that give value and ideological orientation. Because of the singular perspective on war on television, instead of a clash of metaphors, I find a phenomenon that I have called “the dance of metaphors.” The manipulative potential of political metaphors is drawn from interpretive genres. It is directly related to the ideological discourse, as according to Chilton, (1987) the place of metaphorization is on the positive pole of ideological discourse, and of euphemization – on the negative one.
The Web Content оf Digital Marketing Communication As Semantic Capital
Authors:   Faculty of Journalism and Mass Communication, Petkova Teodora
Published: September 2023

The complexity of the communication scenario on the World Wide Web calls for considering interdisciplinary conceptualizations of web content and analyzing its multifaceted nature as a phenomenon of the networked society. Towards that end and for the purposes of theoretical rethinking of web and digital marketing communication artifacts, this paper presents and analyzes the concept of semantic capital. The paper argues that the conceptualization of digital marketing communications as a creation of semantic capital can serve effective marketing communication grounded in a continuum of meaningful interactions between the brand and its stakeholders.
Disinformation and propaganda in the media of the 21st century – a goal achieved or an unsolvable problem
Authors:   Faculty of Journalism and Mass Communication, Milkova Aneta
Published: September 2023

The article aims to present two key concepts in public communications within the context of developing social relations and information technology – propaganda and disinformation. The hypothesis is that propaganda and the making of public opinion are directly related, which in turn enables the delegation of civil rights to leaders of opinion. The article also considers the socially destructive consequences of systemic and prolonged exposure to disinformation. The article also introduces the concept of information chaos, which is the result of the process of disinformation of citizens and consists in considerable behavioral changes.
The (Im)possible Communication of the War: Challenges in Academic Education after the Russian Invasion in Ukraine
Authors:   Faculty of Journalism and Mass Communication, Simeonova Lora
Published: September 2023

Could the war be rationalized, discussed or analyzed within university halls? Has the Bulgarian Alma mater provided adequate answers to the media and communication students’ reasonable questions after the Russian Invasion of Ukraine? How does the worldwide number-one topic influence academic lectures? The report is based on a study amongst 58 second-year Journalism, Public Relations and Book-Publishing students from the Faculty of Journalism and Mass Communication of Sofia University. The results of the questionary show that discussions at university are a significant “compass” for future media and communication specialists in troubled times. War has been turning into a “thin red line” during the classes of the summer semester in 2021/2022. Nevertheless, the majority of the students confess that they would benefit if the topic is even more widely-discussed – especially in the field of media literacy, media ethics and journalism practice.
A New Era in Education: Futuristic Vision for the Transformed “School”
Authors:   Faculty of Journalism and Mass Communication, Dermendjieva Greta
Published: September 2023

At the end of the 20th and the beginning of the 21st century, media technologies reached a level of development capable of liberalizing traditional education. The knowledge gained from conventional education and investment in computer and communication innovations has boomeranged back to reform and made the learning process even more effective. In this report, a typology of forms of education is offered, vividly illustrating the evolution of techniques, methods, means of learning and teaching, and in general – the futuristic (from a modern perspective) idea of the transformation of “school” in its highest sense.
The Alternative Media on The Internet – Forming a New Professional Perspective
Authors:   Faculty of Journalism and Mass Communication, Popova Maria
Published: September 2023

The changes that are taking place in the essence of journalism as a social and professional activity are caused by the mixing of the practice of professional and citizen journalists, by the ability of media products to be distributed through a variety of media and digital channels, by the audience’s commitment not only to consume them through the multiple technological devices, but also personally to participate in their creation. The traditional norms of what journalism is and what are its functions, meaning and influence are a subject of continuous metamorphosis. The new types of journalism increase in the social, professional, and empirical field of media production. The journalism theory is enriched, and the analysis of specific models and professional standards is stimulated. The familiar notion of journalism as centralised around news production is expanded and it allows the description of new practices, which have been assessed as peripheral, hybrid, alternative. The journalism research evaluates new media practices produced by alternative media or those in the field of specialist journalism. The journalists in such start-up media have a sense of the mission of their activity, of being at the forefront of technological, social, and cultural transformations in society, of forming a community culture of exchange between them as content creators and their audience as consumers, but also as participants in the content creation, verification and distribution. Such media can be evaluated as the “agents of media innovation” in relation not only to the professional and social standards in the journalism, but also to the influence that technology and social environment have on the contemporary virtual man.
Methods for Businesses to Deal with the COVID-19 Crisis
Authors:   Faculty of Journalism and Mass Communication, Koleva Bogomila
Published: September 2023

The COVID-19 pandemic has put business organizations in front of a severe test to overcome the many negative consequences of the crisis, related to disruption of supply chains and suspension of activity in various sectors, which could lead to their destruction. Companies face severe challenges in ensuring the continuity of the production process and the provision of services. These new challenges require a quick and efficient response from management, which is undoubtedly based on the construction and implementation of an effective anti-crisis strategy. The purpose of this report is to build a link between theoretical and empirical knowledge about this process and to contribute to the improvement of the overall management activity in crisis conditions. The report‘s central thesis is that every business needs to be prepared to overcome crises long before they occur, as practice, unfortunately, shows that at some stage, their occurrence is inevitable. For this purpose, a methodology is presented that can significantly facilitate managers in their crisis management process. In order to check to what extent business organizations, have an anti-crisis strategy and successful practices for dealing with the crisis of COVID-19, we surveyed 50 company owners from 13 different sectors. Its results are interpreted and compared with other representative studies. The survey shows that the small and medium-sized companies most affected by the crisis still need a pre-prepared anti-crisis action plan. This is a worrying finding because if managers need good tools to prevent and control external and internal threats and work towards constantly testing and updating them, it could have enormous consequences for their business. The situation can be critical, especially for unprepared organizations with no protective tools in reserve.
Repeatability of contactless and contact fingerprint capture
Authors: Libert John M , Orandi Shahram , Grantham John , Ko Kenneth , Bandini Bruce
Published: September 2023

A new generation of contactless fingerprint capture devices has recently emerged. These devices provide the ability to capture a fingerprint without making physical contact with the finger. There is anecdotal evidence that the process of capturing a fingerprint by making contact with it also introduces a certain amount of physical distortion to the finger being pressed against the collection medium. It is hypothesized that because contactless collection devices do not need to make physical contact with the finger bring captured, the resulting collections from contactless devices are expected to have no mechanical deformation introduced to the finger and provide better intraoperability and as well as better consistency between captures from the same device.This hypothesis was rejected in that observations in this study showed that contact collection devices have more consistency and less variability between successive captures using the same
device.