bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
Authors: Freeman Ciara L. , Atkins Reginald , Varadarajan Indumathy , Menges Meghan , Edelman Jeffrey , Baz Rachid , Brayer Jason , Castaneda Puglianini Omar , Ochoa-Bayona Jose Leonel , Nishihori Taiga , Shain Kenneth H. , Shah Bijal , Chen Dung Tsa , Kelley Linda , Coppola Domenico , Alsina Melissa , Antonia Scott , Anasetti Claudio , Locke Frederick L.
Published: November 2023

AbstractPurpose:
We investigated whether a dendritic cell (DC) vaccine transduced with an adenoviral vector encoded with full-length survivin (Ad-S), with mutations neutralizing its antiapoptotic function, could safely generate an immune response and deepen clinical responses when administered before and after autologous stem cell transplant (ASCT) for multiple myeloma.
Patients and Methods:
This phase I first-in-human trial (NCT02851056) evaluated the safety of DC:Ad-S in newly diagnosed multiple myeloma not having achieved complete response with induction, given 7 to 30 days prior to stem cell collection and 20 to 34 days after ASCT. Anti-survivin antibodies and CD4+ and CD8+ specific T cells were quantified.
Results:
A total of 14 patients were treated and 13 included in the primary efficacy analysis. No serious adverse events were attributed to DC:Ad-S vaccine. Detectable anti-survivin antibodies increased from baseline in 9 of 13 (69%) patients, and 11 of 13 (85%) mounted either a cellular or humoral immune response to survivin. Seven patients had an improved clinical response at day +90, all of whom had mounted an immune response, and 6 of 7 patients remain event-free at a median follow-up of 4.2 years. Estimated progression-free survival at 4 years is 71% (95% confidence interval, 41–88).
Conclusions:
Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.

See related commentary by Dhodapkar, p. 4524
Data from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Authors: Paolino Jonathan , Dimitrov Boris , Apsel Winger Beth , Sandoval-Perez Angelica , Rangarajan Amith Vikram , Ocasio-Martinez Nicole , Tsai Harrison K. , Li Yuting , Robichaud Amanda L. , Khalid Delan , Hatton Charlie , Gillani Riaz , Polonen Petri , Dilig Anthony , Gotti Giacomo , Kavanagh Julia , Adhav Asmani A. , Gow Sean , Tsai Jonathan , Li Yen Der , Ebert Benjamin L. , Van Allen Eliezer M. , Bledsoe Jacob , Kim Annette S. , Tasian Sarah K. , Cooper Stacy L. , Cooper Todd M. , Hijiya Nobuko , Sulis Maria Luisa , Shukla Neerav N. , Magee Jeffrey A. , Mullighan Charles G. , Burke Michael J. , Luskin Marlise R. , Mar Brenton G. , Jacobson Matthew P. , Harris Marian H. , Stegmaier Kimberly , Place Andrew E. , Pikman Yana
Published: November 2023

AbstractPurpose:
Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations to inform therapy.
Experimental Design:
We describe a cohort of 14 pediatric patients with relapsed or refractory T-ALL enrolled on the Leukemia Precision-based Therapy (LEAP) Consortium trial (NCT02670525) and a patient with T-LBL, discovering alterations in platelet-derived growth factor receptor-α (PDGFRA) in 3 of these patients. We identified a novel mutation in PDGFRA, p.D842N, and used an integrated structural modeling and molecular biology approach to characterize mutations at D842 to guide therapeutic targeting. We conducted a preclinical study of avapritinib in a mouse patient-derived xenograft (PDX) model of FIP1L1-PDGFRA and PDGFRA p.D842N leukemia.
Results:
Two patients with T-ALL in the LEAP cohort (14%) had targetable genomic alterations affecting PDGFRA, a FIP1-like 1 protein/PDGFRA (FIP1L1-PDGFRA) fusion and a novel mutation in PDGFRA, p.D842N. The D842N mutation resulted in PDGFRA activation and sensitivity to tested PDGFRA inhibitors. In a T-ALL PDX model, avapritinib treatment led to decreased leukemia burden, significantly prolonged survival, and even cured a subset of mice. Avapritinib treatment was well tolerated and yielded clinical benefit in a patient with refractory T-ALL.
Conclusions:
Refractory T-ALL has not been fully characterized. Alterations in PDGFRA or other targetable kinases may inform therapy for patients with refractory T-ALL who otherwise have limited treatment options. Clinical genomic profiling, in real time, is needed for fully informed therapeutic decision making.
Table S2 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

Detailed information about patients with BRCA1/2 and TP53 pathogenic germline variants
Table S1 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

List of potentially actionable cancer susceptibility genes (CSGs)
Figure S2 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

Distribution of variant allele frequency
Figure S1 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

The time-related changes in the OncoGuideTM NCC oncopanel system
FIGURE 4 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

A, Distribution of germline and somatic variants categorized as pathogenic in the OncoGuide NOP. CSGs that were subject to PGV reporting in NOP Ver.2 were analyzed using only the NOP Ver.2 data, and CSGs that were subject to PGV reporting in NOP Ver.1 were analyzed using the NOP data for the entire period. Numbers in the graph indicate the number of variants. B, Proportion of pathogenic variants in FoundationOne CDx recommended for germline-focused analysis using European Society for Medical Oncology recommendations. Numbers in the graph indicate the number of variants.
FIGURE 3 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

Distribution of germline variants categorized as pathogenic, benign, and of uncertain significance in the OncoGuide NOP. CSGs that were subject to PGV reporting in NOP Ver.2 were analyzed using only the NOP Ver.2 data, and CSGs that were subject to PGV reporting in NOP Ver.1 were analyzed using the NOP data for the entire period. Numbers in the graph indicate the number of variants.
FIGURE 2 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

Proportion of patients (A) and CSGs (B) with PGVs by age group in the OncoGuide NOP. Analysis was performed using NOP data for the entire period, limited to only the CSGs subject to reporting of PGVs from NOP Ver.1.
FIGURE 1 from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

Prevalence of PGVs by cancer type and gene in the OncoGuide NOP. Analysis was performed using NOP data for the entire period, limited to only the cancer susceptibility genes subject to reporting of PGVs from NOP Ver.1. Shades of color correspond to the prevalence of PGVs in cancer types, with light to dark representing <5%, 5%–10%, and >10%.
Data from Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients
Authors: Satake Tomoyuki , Kondo Shunsuke , Tanabe Noriko , Mizuno Takaaki , Katsuya Yuki , Sato Jun , Koyama Takafumi , Yoshida Tatsuya , Hirata Makoto , Yamamoto Noboru
Published: November 2023

Abstract
Cancer genome profiling (CGP) occasionally identifies pathogenic germline variants (PGV) in cancer susceptibility genes (CSG) as secondary findings. Here, we analyzed the prevalence and clinical characteristics of PGVs based on nationwide real-world data from CGP tests in Japan. We analyzed the genomic information and clinical characteristics of 23,928 patients with solid cancers who underwent either tumor-only (n = 20,189) or paired tumor-normal (n = 3,739) sequencing CGP tests between June 2019 and December 2021 using the comprehensive national database. We assigned clinical significance for all variants and highlighted the prevalence and characteristics of PGVs. Our primary analysis of the tumor-normal sequencing cohort revealed that 152 patients (4.1%) harbored PGVs in 15 CSGs. Among 783 germline variants, 113 were annotated as PGVs, 70 as benign variants, and 600 as variants of uncertain significance. The number of PGVs identified was highest in BRCA1/2, with 56, followed by TP53, with 18. PGVs were the most prevalent in ovarian and peritoneal cancers, including among cancer types common in Asia. In the tumor-only sequencing cohort, of the 5,184 pathogenic somatic variants across 26 CSGs, 784 (15.1%) were extracted according to the European Society for Medical Oncology recommendations for germline-focused tumor analysis. The prevalence of PGVs was similar to that previously reported in Europe and the United States. This is the largest analysis based on real-world tumor-normal sequencing tests in Asia. The more widespread use of the tumor-normal sequencing CGP test could be reasonable for evaluating PGVs.
Significance:
We analyzed real-world data from over 23,000 patients in Japan, revealing 4.1% harbored PGVs, particularly in BRCA1/2 and TP53, in CSGs. It highlights the prevalence of PGVs in Asian populations and supports the broader adoption of tumor-normal sequencing CGP tests for PGV evaluation.
Triamcinolone Acetonide Injections in Nail Psoriasis: A Pragmatic Analysis
Authors: Grover Chander , Kharghoria Geetali , Bansal Shikha
Published: November 2023

Introduction: Treatment of nail psoriasis is challenging. Systemic therapies may be difficult to justify, while topical therapies may be sup-optimal. Triamcinolone acetonide (TA) injections are recommended as first-line therapy in cases with less than 3 nails involved; however, limited studies are available. This study was conducted to evaluate the reduction in NAPSI (Nail Psoriasis Severity Index) with TA injections in patients with isolated nail psoriasis. Methods: A retrospective case record analysis of efficacy and safety of TA (5 mg/mL) nail injections (4-weekly for fingernails, 8-weekly for toenails) was done in 10 patients. NAPSI was evaluated at each visit and treatment endpoint (75% reduction or 10 injections, whichever was earlier). Dropouts and adverse effects were recorded. Results: Among 10 patients (94 involved nails, 61 fingernails, and 33 toenails), 3 patients (30%) dropped out (2, 4, and 5 sessions, respectively), citing procedural pain. Three patients achieved NAPSI-75 (3, 6, and 7 sessions, respectively). Baseline mean NAPSI of 5.03 (4.63 fingernails and 5.78 toenails) dropped to 3.67 (3.13 fingernails and 4.42 toenails) by the 5th injection; and 2.35 (2.13 fingernails and 2.59 toenails) by the 10th injection. Adverse effects included pain (30%), subungual haematoma (1.7%), and proximal nail fold hypopigmentation with mild atrophy (1.1%). Conclusions: TA (5 mg/mL) injections are effective in nail psoriasis and associated with minimal adverse effects.
A new cave-dwelling hadzioid amphipod (Senticaudata, Hadzioidea, Melitidae) from sulfidic groundwaters in Iran
Authors: Malek-Hosseini Mohammad Javad , Brad Traian , Fatemi Yaser , Kuntner Matjaž , Fišer Cene
Published: November 2023

Cave systems fed with hydrogen sulfide-rich groundwater are unique chemoautotrophy-dependent ecosystems. Although globally widespread and known to harbor unique subterranean metazoan communities, they have mostly been studied in Europe and North America, less so in Asia. Here, we report on a discovery of a new species of amphipod crustacean from sulfidic waters of Tashan-Chah Kabootari aquifer from Zagros Mountains in Iran. The new species corresponds morphologically to the melitid genus Tegano Barnard & Karaman, 1982, and Tegano tashanensis sp. nov. is the first amphipod from the superfamily Hadzioidea found exclusively in sulfidic water. Phylogenies derived from the mitochondrial coi and the nuclear 28S rRNA sequences recover T. tashanensis sp. nov. in a clade that contains representatives of the currently para- or polyphyletic genera Barnardomelita, Brachina, Josephosella, and Tegano indicating the need for a revised melitid genus level systematics. This clade comprises marine, freshwater and subterranean species globally distributed in regions that were connected by the ancient Tethys Sea. As such, these taxa may be suitable biogeographic models for studying past dispersal, vicariance and multiple colonization of inland groundwaters.
Colloquium 1 Gazing at the Sun: Contemplation of the One and Happiness in the Philosophy of Plotinus
Authors: Stróżyński Mateusz
Published: November 2023

The paper explores the link between contemplation of the One and happiness in Plotinus and challenges the traditional interpretation according to which a contemplative or mystical experience of the One is by necessity brief and transitory, while the experience of Intellect can become a stable state in this life. Were it so, it would not serve as a ground for the good or happy life. In order to reconcile this point with Plotinus’s other claim about contemplation, his doctrine of the double activity of Intellect is invoked.
Colloquium 3 Commentary on Hayes
Authors: Pfeiffer Christian
Published: November 2023

In his paper, Josh Hayes argues that inclination (ῥοπή) is the nature of each element. It is an active and passive principle that explains why the elements move to their proper places. Thus, according to Hayes, by introducing inclination in De Caelo IV 1, Aristotle posits a single explanatory factor that accounts for all elemental motions. By doing so, he answers the question, posed in Physics VIII 4, of what the cause of elemental motion is. In my comments, I will contest these claims. Aristotle’s theory of elemental motion does not rely on a single explanatory factor; yet, it is not, as Hayes claims, incoherent. Instead, the different strands merely reflect the special nature of the elements.
II. The World Work in Language(s)
Authors: Reynolds Matthew
Published: November 2023

This chapter explains the theory of language and translation that underpins the volume. Language is a continuum of difference, and translation is a bordering practice that contributes to the organisation of that continuum; it defines boundaries between languages by the act of crossing them. Furthermore, a translation is never simply into a language; it is always into a more particular linguistic repertoire. The chapter goes on to assert the fundamental importance of paying close attention to language in a world literary context. It provides a reading of the language politics of Jane Eyre as Charlotte Brontë wrote it, showing that, while the novel is open to language difference (including the radical difference of Bertha’s speech), Jane as a character has to adopt a narrower conception of linguistic discipline. The chapter concludes by arguing that translations expand the signifying potential of the source text – a process that will be fully explored in the essays and chapters to come.
1. Jane, Come with Me to India
Authors: Kragh Ulrich Timme , Jain Abhishek
Published: November 2023

The essay presents the reception of Jane Eyre on the Indian subcontinent. It examines the Indian motif within Brontë’s novel, surveys seven literary and cinematographic Jane Eyre adaptations in five Indian languages produced between 1914 and 1972, discusses the history of Indian translation practices and presents eighteen Jane Eyre translations into nine Indian languages that appeared between 1953 and 2020, and finally synoptically analyses four passages from two literal translations into Hindi and Kannada and an abridged translation into Gujarati. Throughout, the essay proposes a new approach to narrative analysis based on an Indian dramaturgical model, a new definition of translation and adaptation based on the Indian philosophical notion of transformation, and a new criterion drawn from Indian poetics for distinguishing between the notions of adaptation, abridgement, and translation.
2. Who Cares What Shape the Red Room is?
Authors: Gaudio Paola
Published: November 2023

The aim of this essay is to identify patterns of textual variation that affect both the source text(s) and its translations. Starting with the substitution of the word ‘spare’ with ‘square’ in the ‘red-room’ episode, textual variations are analysed in a selection of English editions of Charlotte Brontë’s Jane Eyre published by prestigious publishing houses such as Collins, Harper, Oxford, Norton Critical, and Penguin―from the second half of the nineteenth-century to the most recent editions, including e-books (Amazon) and *.txt files (Project Gutenberg). Variations in English editions are compared against the original Brontë’s manuscript (1847) and tracked down in eleven Italian translations.
7. Searching for Swahili Jane
Authors: Drury Annmarie
Published: November 2023

While Jane Eyre has travelled widely, it remains absent from most languages of sub-Saharan Africa. This chapter explores a failure of transmission through translation by focusing on a specific literary sphere, that of Swahili. It traces a culture of translation that has not (yet) admitted Brontë, one in which the nineteenth-century British novel had a role in colonial enforcement of language norms. After suggesting that Swahili translations of Alice in Wonderland might point to a place for Brontë’s novel, the chapter explores preoccupations shared by Jane Eyre and Euphrase Kezilahabi’s novel Rosa Mistika (1971) and Mwana Kupona binti Msham’s nineteenth-century poem Utendi wa Mwana Kupona (Mwana Kupona’s Poem); it highlights bird imagery in the novels and themes of power, education, and femininity across all three texts.
Natural drug asiaticoside inhibits osteoclast differentiation and promotes repair of steroid-induced osteonecrosis of femoral head via RANKL pathway
Authors: Wu Haijian , Guo Bowen , Zhong Hongfa , Ying Hui
Published: November 2023

Asiaticoside is one of the most classic traditional Chinese medicines. The interaction between Receptor activator of nuclear factor κB (RANK) and Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) activates a series of intracellular signaling pathways.
Our research explored the mechanism of asiaticoside inhibiting osteoclast differentiation and repair of steroid-induced osteonecrosis of femoral head (SIONFH) through RANKL pathway. Asiaticoside’s effect on osteoclasts was determined by Microneedle Therapy System (MTS) method, and the
number of Tartrate resistant acid phosphatase (TRAcP) multinucleated cells (3 nuclei) was quantitatively analyzed. Under different dose treatments, the changes of bone function were detected by eroded area and TRAcP staining on hydroxyapatite-coated plate, and the expression of different osteocyte
formation and osteogenic differentiation were detected. Asiaticoside weakened the osteoclast function induced by RANKL. When the concentration of asiaticoside was 10 μmol/L, osteoclast formation regulatory genes (NFATc1 and Acp5) and osteoclast cell function-related genes (AP-1 and
P65) were significantly downregulated in the presence of RANKL. Asiaticoside (10 μmol/L) significantly decreased calcium oscillations induced by RANKL via preventing RANKL-mediated NF-κB activation and Ca2+ oscillation.
The preparation of pre-alphacalcidol by high performance liquid chromatography
Authors: Qiu Yanchuan , Ma Lian , Wang Hui
Published: November 2023

Pre-alfacalcidol is an active substance, and the UV response of pre-alfacalcidol and alfacalcidol is different, there will be errors in the content determination process. The main reason is that pre-alfacalcidol is very unstable and easy to tautomerize with alfacalcidol at room temperature.
Therefore, it is very necessary to control the content of pre-alfacalcidol and alfacalcidol when determining the content of alfacalcitol tablets. In order to fully study the quality of Alfacalcidol tablets, here, we reported a preparation method of pre-alfacalcidol. In this study, pre-alfacalcidol
was prepared by directional degradation and purified by high performance liquid chromatography (HPLC) and its structure was identified by high resolution mass spectrometer (HRMS) and nuclear magnetic resonance (NMR). The preparation process is simple, and the cycle is short at a low cost with
a high yield. The purity of pre-alfacalcidol is more than 95%, which can meet the requirements of standard products. At the same time, under the condition of high temperature preparation, the undamaged alfacalcidol can be collected and recovered, which greatly improves the availability and
reduces the cost. In summary, this method has important significance to strictly control the quality of raw materials and preparations of alfacalcidol and improve the efficacy of alfacalcidol tablets.
Antioxidant, cytotoxicity, and anti-prostate carcinoma effects of CuO nanoparticles containing Thymus vulgaris
Authors: Li Bing , Wang Yufeng , Bian Yukun , Gao Zhizhang
Published: November 2023

In this work, we have described the green supported of CuO NPs over Thymus vulgaris (CuNPs) as a reducing/stabilizing nanocomposite in alkaline medium. In the cellular and molecular part of the recent study, the treated cells with CuNPs were assessed to determine the cytotoxicity
and anti-human prostate carcinoma properties on prostate carcinoma cell lines i.e., LNCaP clone FGC-Luc2, 22Rv1, and NCI-H660. The morphological and physicochemical features of the prepared nanocomposite were determined using several advanced techniques as Field Emission Scanning Electron
Microscopes (FE-SEM), Ultraviolet–visible spectroscopy (UV-Vis), and fourier transform infrared spectroscopy (FTIR) studies. In the antioxidant test, the IC50 of CuNPs and butylated hydroxytoluene (BHT) against 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals were 94 and 88 μg/mL,
respectively. The IC50 of CuNPs were 191, 275, and 250 μg/mL against LNCaP clone FGC-Luc2, 22Rv1, and NCI-H660 cell lines, respectively. In conclusion, our data suggest that the malignant prostate cell lines viability decreased in the CuNPs presence.
Modulation of two-dimensional Pt-based intermetallic nanoplates for fuel cells
Authors: Guo Jingchun , Wang Ran , Yu Jiao , Zhang Zhilin , Fu Xucheng
Published: November 2023

Recently, ultrathin two-dimensional (2D) noble-metal-based nanomaterials have gained a lot of attention due to their interesting physicochemical properties and widespread promising applications. In particular, 2D Pt-based intermetallic nanoplates (IMNPs) have been widely studied in
cathodic oxygen reduction reaction (ORR), anodic methanol, formic acid, and ethanol oxidation reactions (MOR, FAOR, and EOR) of fuel cells (FCs). In this article, we first give a fundamental understanding of the FCs. Subsequently, several modulation strategies for 2D Pt-based IMNPs including
alloying, doping, facet engineering, heterogeneous structure construction, defect and interface engineering, as well as their applications in ORR, MOR, FAOR, and EOR are briefly summarized. Finally, we discuss the current challenges and give our perspectives on the synthesis of high-performance
2D Pt-based IMNPs toward FCs.
Effect of quercetin on acute appendicitis by reduction of Caspase-1 and inflammatory factors release through Toll-like receptor 4/nuclear factor kappa-B pathway
Authors: Wang Gang , Han Dan , Zhang Qingyu
Published: November 2023

It has been reported that, quercetin can improve body’s inflammatory response through Toll-like receptor 4/nuclear factor kappa-B (TLR4/NF-κB) signaling, thereby playing a role in treating acute appendicitis. Firstly, acute appendicitis model was established in rats,
where blank group, acute appendicitis model group, and quercetin intervention group (quercetin group) were set up to detect the effect of quercetin on acute appendicitis. In addition, the model, Toll-like receptor 4 inhibitor (TAK-242), Lipopolysaccharides (LPS), quercetin+ TAK-242, and quercetin+LPS
groups were set to assess whether quercetin reduces Caspase-1 (CASP-1) through TLR4/NF-KB signaling and regulates the release of inflammatory factors to exert the effect on treating acute appendicitis. (1) Quercetin significantly inhibited the biological effects of tissue inflammation in rats
with appendicitis and this process was related to decreased expression of TLR4 and NF-κB; (2) Quercetin also inhibited TLR4 and NF-κB expression and after using TLR4 inhibitors, the release of inflammatory factors in rat appendix tissue was controlled, especially
in the quercetin+TAK-242 group. Quercetin can significantly block the development of inflammatory response in acute appendicitis, and this process is mainly achieved by reducing inflammatory factors. In addition, quercetin can effectively inhibit TLR4/NF-κB signaling related to
anti-inflammatory effect, thereby down-regulating the expression of CASP-1, and finally inhibiting the inflammatory response of acute appendicitis.
The effect of endogenous bone marrow derived mesenchymal stem cells on the activity of β-catenin signaling pathway on chemotherapy resistance of osteosarcoma
Authors: He Haibo , Wu Wenxin , He Jun , Su Xiaotao , Gui Qianhuan
Published: November 2023

This study assesses the effect of bone marrow derived mesenchymal stem cells (BMSC) on chemotherapy resistance of osteosarcoma. 60 SPF mice were randomly separated into control group and model group. Serum alkaline phosphatase (ALP), Calcium (Ca), Phosphorus (P) and tumor formation
rate were observed. The osteosarcoma tissues were taken to construct drug-resistant osteosarcoma cell lines. Control group, 5-fluorouracil (5-Fu) group, BMSC group, 5-Fu+BMSC group, and then set 5-Fu+BMSC+agonist group, 5-Fu+BMSC+inhibitor group, respectively. Osteosarcoma cell sensitivity
to 5-Fu (IC50) and β-catenin/p-β-catenin expression were examined. Compared with control group, the ALP level and tumor formation rate in model group were higher and P level was remarkably lower. Ca level showed no difference between two groups (P >0.05).
The 5-Fu+BMSC group and 5-Fu group had the highest IC50 levels and the control group and BMSC group had the lowest IC50 levels. The β-catenin/p-β-catenin expressions were the highest in 5-Fu+BMSC group and 5-Fu group, and their expressions in control group and BMSC
group were the lowest. 5-Fu+BMSC+agonist group showed higher β-catenin, p-β-catenin and IC50 levels, which are lower in 5-Fu+BMSC+inhibitor group. Endogenous BMSC can promote the chemotherapy resistance of osteosarcoma. They can promote β-catenin and β-catenin
phosphorylation level, down-regulate osteosarcoma cell sensitivity to 5-Fu, and then promote drug resistance. Therefore, β-catenin signaling can be used as a target to reverse the resistance of osteosarcoma cells to 5-Fu.
The inhibitory effect of quercetin on chemotherapeutic drug resistance of gastric cancer through forkhead box D3 signaling pathway
Authors: Chang Liqian , Gao Yuan , An Na
Published: November 2023

Most gastric cancer patients have cancer cell metastasis at the time of being diagnosed. Cisplatin chemotherapy can slow down the development of gastric cancer, but the drug resistance will develop after a long time of chemotherapy. Previous studies have found that quercetin improves
resistance of chemotherapy drugs. Therefore, this study intends to explore quercetin’s role in gastric cancer. SGC-7901 drug-resistant cell line was cultured and intervened. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay assessed cell proliferation, cell survival
rate, IC50 value and sensitivity along with analysis of cell apoptosis, proliferation by colony formation assay and qRT-PCR (real-time reverse transcription-PCR) and Western blot detection of FOXD3 (Forkhead box D3) levels. Gastric cancer xenograft tumor mouse model was established to assess
its in vivo role. The drug-resistant cell model of gastric cancer was successfully constructed and quercetin inhibited cell survival to a certain extent and improved its chemosensitivity. The pro-apoptotic effect of quercetin on cisplatin chemotherapy resistance in gastric cancer is
related to the increased FOXD3 level. Quercetin can directly regulate the expression of FOXD3, which is an activation effect. The inhibition rate of gastric cancer mice in vivo was the most prominent in the quercetin+drug resistance group. The tumor-bearing site was significantly reduced
and the number of surviving mice was the highest, whose tumor volume was consistently lower than that of other groups. Conclusively, quercetin has a strong anti-tumor effect. It can inhibit gastric cancer cell activity and accelerate apoptosis by activating FOXD3 signaling pathway.
Effect of metformin nanoemulsion through AMP-activated protein kinase (AMPK)-mediated autophagy on diabetic neuropathy
Authors: Liu Fengmin , Wang Siyun , Du Xiaojuan , Xie Diya
Published: November 2023

Metformin (MET) is the preferred first-line treatment for patients with type 2 diabetes. However, the mechanism of diabetic peripheral neuropathy (DPN) is still unclear. To improve the oral utilization of metformin, a metformin nanoemulsion (MET-NE) was prepared to investigate its effects
on DPN and its underlying mechanism. In this study, a DPN model was established in Wistar rats induced by streptozotocin (STZ). The diabetic rats were randomly divided into four groups: the diabetic model group (DM group), the metformin tablet-treated group (MET group), the metformin nanoemulsion-treated
group (MET-NE group), and a normal control group consisting of five normal Wistar rats. All groups were administered the treatment orally for a period of 10 weeks. The findings of the study demonstrated that both MET and MET-NE significantly reduced blood glucose levels, glycated serum protein
levels, food intake, and water intake in DM rats. It was also observed that MET-NE was more effective than MET in reducing blood glucose levels. Additionally, both MET and MET-NE treatments significantly increased the motor nerve conduction velocity (MNCV), sensory nerve conduction velocity
(SNCV), and sensory nerve action potential (SNAP) amplitude in DM rats. Furthermore, these treatments improved mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL), resulting in a reduced sensitivity to pain stimuli. Moreover, both MET and MET-NE treatments promoted the
phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) proteins, as well as increased the activity of autophagic proteins in the sciatic nerve. However, no significant differences were observed between MET and MET-NE treatments in terms of these effects. In
conclusion, the MET-NE demonstrated a rapid decrease in blood glucose levels and improved glucose tolerance and metabolism, which was found to be superior to MET. Furthermore, MET-NE significantly improved the neurophysiological function and sciatic nerve pain threshold in DPN rats. These
beneficial effects may be attributed to the regulation of AMPK-mediated autophagy by MET-NE.
Effect of combining nano-silver dressing and vacuum sealing drainage with negative pressure treatment on patients with diabetic foot ulcers
Authors: Jin Liang , Niu Chao , Ni Yulong
Published: November 2023

This study investigates the efficiency of the combination of nano-silver dressing and vacuum sealing drainage (VSD) with negative pressure treatment on healing diabetic foot ulcers (DFU). A total of 100 patients with DFU admitted to our hospital between January 2022 and February 2023
were selected and randomly divided into a control group and an observation group, each consisting of 50 cases. Both groups received nano-silver dressings after debridement, but the observation group also underwent closed negative pressure drainage. Scores for wound granulation morphology and
comfort were assessed before and after treatment. Efficacy rate, healing time, and clinical outcomes were evaluated before and after treatment. Serum levels of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and cystatin C were measured before treatment
and 30 days into treatment. After 10 days of treatment, the observation group showed a higher effective rate (96%) compared to the control group (88%). The observation group had better wound granulation morphology and comfort scores, shorter granulation and healing times, reduced hospitalization
duration, and smaller wound areas than the control group. Both groups experienced decreased levels of IL-6, PCT, hs-CRP, and cystatin C after treatment. The observation group had lower levels of these markers compared to the control group. In conclusion, the combination of nano-silver dressing
and VSD with negative pressure treatment improves the clinical efficacy of treating DFU. This approach reduces inflammation and promotes wound healing, as evidenced by improved wound scores, faster healing times, and reduced inflammatory marker levels.
Application of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask to head and neck neoplasm radiotherapy
Authors: Zheng Chunyuan , Li Xueya , Zhu Luchao , Zhang Zhiqiang , Wang Yuanzhang , Lin Yihang , Wu Qiong , Zhang Meiling
Published: November 2023

This study investigated the effectiveness of customisable 3D-printed bite blocks combined with nano head, neck and shoulder mask in radiotherapy for head and neck neoplasms. The images of 50 patients with head and neck neoplasms treated at our hospital from 2020 to 2022 were collected
using CBCT. The patients were divided into two groups: 25 in the mask group and 25 in the combination group. The mask group utilized thermoplastic polyurethane (TPU) nanofiber membrane to stabilize the position of the patients’ head, shoulder, and neck. On the other hand, the combined
group added a personalized bite block produced by 3D printing technology on the basis of the mask group. Cone beam CT (CBCT) was used to calibrate any errors, and the set-up errors and number of head rotations after image calibration were analyzed between the two groups. The conformation number
(CN) and heterogeneity index (HI) in the target area of the intensity-modulated radiation therapy (IMRT) plan of the two groups were calculated, and the dose-volume parameters of the tongue and other organs at risk, including Dmax and Dmean, were compared using paired tests. Follow-up observations
were performed to assess the occurrence of adverse reactions to radiation damage among the patients. The findings revealed a statistically significant difference in the Y -axis set-up error between the combination group and the mask group (P < 0.05). Additionally, the combination
group exhibited a higher proportion of set-up errors < 2 mm in both the Y -axis and Z-axis directions compared to the mask group. Significantly fewer images showed head rotation in the combination group than in the mask group. In terms of the target area, there were no significant
differences observed in the conformation number (CN) and heterogeneity index (HI) between the two groups. However, wearing the personalized bite block resulted in significantly lower Dmax and Dmean values for the tongue. In contrast, the mask group experienced a higher incidence of oral mucositis
and taste disorders. By utilizing customizable 3D-printed bite blocks in conjunction with a nano-mask, accurate repositioning for chemotherapy was achieved, leading to a reduction in set-up error and a significant decrease in radiation dose to the tongue and its surface oral mucosa. Consequently,
the occurrence of adverse reactions such as oral mucositis and taste disorders was also reduced. The production of personalized bite blocks is simple, with accurate radiotherapy, making it a technique that should be widely adopted.
Application of smart sportswear based on multi-walled carbon nanotubes for safety in college physical education classes
Authors: Hu Nan , Wang Baixu
Published: November 2023

As physical education advances, college physical education classrooms are becoming increasingly diverse, but this development also brings security concerns. Intelligent sportswear, serving as a real-time monitoring device for human data, can enhance safety for both teachers and students.
This study focuses on developing a conductive filler for flexible piezoresistive sensors using modified multi-walled carbon nanotubes (MWCNTs). Firstly, the tunneling theory and permeability effects are employed to establish a sensing mechanism model and analyze the conductivity and piezoresistive
effects. Subsequently, silane coupling agents (KH550) and sodium dodecyl benzene sulfonate (SDBS) are chosen to enhance the conductive filler’s performance. Finally, smart gloves, smart insoles, and smart vests are designed for the detection of hand pressure, foot pressure, and respiratory
rate. This aims to enhance safety measures in physical education classrooms. Furthermore, their performance is validated through simulation experiments. Results indicate that MWCNTs were modified with KH550 and SDBS, showing improved conductivity with higher filler concentration. KH550-SDBS-MWNT/PU
material demonstrates 108.3% increased elongation at break, 9% reduction in nonlinear error, enhanced linearity, and 2.972 sensitivity increase. Displacement deviation analysis reveals load change trends based on filler concentration. Empirical analysis of smart clothing, like smart insoles,
aligns sensor data with theoretical principles, highlighting the potential for flexible sensor performance enhancement. In conclusion, the modified MWCNs have demonstrated potential for enhancing the performance of flexible sensors.
Primary School Teachers’ Adaptations for Struggling Writers: Survey Study of Grade 1 to 6 Teachers in Australia
Authors: Malpique Anabela , Pino-Pasternak Deborah , Valcan Debora , Asil Mustafa
Published: November 2023

Two hundred ninety-eight primary teachers (88% female) from across all Australian states and territories reported on the frequency with which they implemented instructional adaptations for struggling writers in their classrooms. They also rated their preparation and self-efficacy for teaching writing. The majority of participating teachers indicated they provided additional instruction on spelling, capitalization and punctuation, and sentence construction at least once a week or more often. Teachers further reported implementing additional minilessons and reteaching strategies and skills, as well as extra instruction on grammar, handwriting, text structure, revising, and planning on a monthly basis or more often. The majority of teachers reported never or only once a year using adaptations to support digital writing. The frequency with which teachers provided extra instruction on spelling, handwriting, text structure, revising, and computer use differed by grade. Only teachers’ perceived efficacy to teach writing made a unique and statistically significant contribution to predicting the use of instructional adaptations for writing and adaptations to support digital writing after controlling for teacher and classroom variables.
“Statistical Significance” and Statistical Reporting: Moving Beyond Binary
Authors: McShane Blakeley B. , Bradlow Eric T. , Lynch John G. , Meyer Robert J.
Published: November 2023

Null hypothesis significance testing (NHST) is the default approach to statistical analysis and reporting in marketing and the biomedical and social sciences more broadly. Despite its default role, NHST has long been criticized by both statisticians and applied researchers, including those within marketing. Therefore, the authors propose a major transition in statistical analysis and reporting. Specifically, they propose moving beyond binary: abandoning NHST as the default approach to statistical analysis and reporting. To facilitate this, they briefly review some of the principal problems associated with NHST. They next discuss some principles that they believe should underlie statistical analysis and reporting. They then use these principles to motivate some guidelines for statistical analysis and reporting. They next provide some examples that illustrate statistical analysis and reporting that adheres to their principles and guidelines. They conclude with a brief discussion.
Diaper Need: It’s Time for a Change in Practice and Policy
Authors: Barreca Jessica
Published: November 2023

Over one-third of families in the United States experience diaper need, negatively affecting the health and developmental outcomes of young children. Research has shown that when providers recognize the importance of addressing the social determinants of health (SDOH), including diaper need, critical support is provided to children and families. Early intervention (EI) providers work collaboratively with families to address goals for their children, including SDOH. Through longitudinal partnerships with families, EI providers are ideally positioned to address disparities like diaper need and provide essential supports to families. When diaper need affects children with developmental delays and disabilities, the disparities are often exacerbated due to the extended length of time that may be required for the child to wear diapers. EI providers can address this need by increasing awareness of this issue, connecting families to resources, and advocating for policy changes to effectively address diaper need and optimize outcomes for children.
Enhancing low-pressure stage steam turbine using the TDLD criterion and the TOPSIS analysis
Authors: Dolatabadi Reza , Lakzian Esmail , Masoumi Samaneh , Dykas Sławomir , Karimi Nader , Benkhaldoun Fayssal , Vlaskin Mikhail S
Published: November 2023

The liquid phase in the wet steam flow causes thermodynamics losses and affects steam turbine blade durability. The main objective of the present research is the design of the rotor stagger angle and different operating conditions in the low-pressure stage of the steam turbine. A two-phase Eulerian-Eulerian model and the SST k − ω model are used to simulate the viscous wet steam flow inside the steam turbine stage. Frozen rotor methodology is employed for modeling the stator-rotor interaction. The effects of different rotor stagger angles and different outlet pressure levels on the wet steam flow parameters are studied to introduce an improved case. The turbine stage efficiency, droplet average radius, liquid mass fraction, and degree of reaction (TDLD) are considered as design criteria. The search for the improved value of pressure ratio and rotor stagger angle is performed using the TDLD criterion by TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution). The improved case is selected with a rotor stagger angle of 64 degrees and outlet pressure of 6.5 kPa, at which the turbine stage efficiency (TSE) is increased by 21.3% compared to [Formula: see text]. Also, the liquid mass fraction (LMF) and the degree of reaction (DOR) reduced by 39.53 and 26% relative to [Formula: see text], and [Formula: see text], respectively. In addition, droplet average radius (DAR) increases by 26.14% compared to [Formula: see text].
Epidemiology and outcomes of emergency department visits in systemic lupus erythematosus: Insights from the nationwide emergency department sample (NEDS)
Authors: Dhital Rashmi , Pokharel Ashbina , Karageorgiou Ioannis , Poudel Dilli R , Guma Monica , Kalunian Kenneth
Published: November 2023

Background

Systemic lupus erythematosus (SLE) patients are prone to frequent emergency department (ED) visits. This study explores the epidemiology and outcomes of ED visits by patients with SLE utilizing the Nationwide Emergency Department Sample (NEDS).

Methods

Using NEDS (2019), SLE ED visits identified using ICD-10 codes (M32. xx) were compared with non-SLE ED visits in terms of demographic and clinical features and primary diagnoses associated with the ED visits. Factors associated with inpatient admission were analyzed using logistic regression. Variations in ED visits by age and race were assessed.

Results

We identified 414,139 (0.35%) ED visits for adults ≥ 18 years with SLE. ED visits with SLE comprised more women, Black patients, ages 31–50 years, Medicare as the primary payer, and had higher comorbidity burden. A greater proportion of Black and Hispanic SLE patients who visited the ED were in the youngest age category of 18–30 years (around 20%) compared to White patients (less than 10%). Non-White patients had higher Medicaid utilization (27%–32% vs 19% in White patients). Comorbidity patterns varied based on race, with more White patients having higher rates of hyperlipidemia and ischemic heart disease (IHD) and more Black patients having chronic kidney disease (CKD), hypertension, and heart failure. Categorizing by race, SLE/connective tissue disease (CTD) and infection were the most prevalent primary ED diagnosis in non-White and White patients, respectively. Age ≥ 65 years, male sex, and comorbidities were linked to a higher risk of admission. Black race (OR 0.86, p = .01) and lowest income quartile (OR 0.78, p = .003) had lower odds of inpatient admission.

Conclusion

Infection and SLE/CTD were among the top diagnoses associated with ED visits and inpatient admission. Despite comprising a significant proportion of SLE ED visits, Black patients had lower odds of admission. While the higher prevalence of older age groups, hyperlipidemia, and IHD among White patients may partly explain the disparate results, and further study is needed to understand the role of other factors including reliance on the ED for routine care compared among Black patients, differences in insurance coverage, and potential socioeconomic biases among healthcare providers.