bluuebunny/crossref_metadata_2025 huggingface dataset:
A review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of the Astragalus memeranaceus
Authors: Wang Panpan , Wang Zhen , Zhang Zhanping , Cao Huiyan , Kong Lingyang , Ma Wei , Ren Weichao
Published: August 2023

Astragali Radix (Huangqi) is mainly distributed in the Northern Hemisphere, South America, and Africa and rarely in North America and Oceania. It has long been used as an ethnomedicine in the Russian Federation, Mongolia, Korea, Kazakhstan, and China. It was first recorded in the Shennong Ben Cao Jing and includes the effects of reinforcing healthy qi, dispelling pathogenic factors, promoting diuresis, reducing swelling, activating blood circulation, and dredging collaterals. This review systematically summarizes the botanical characteristics, phytochemistry, traditional uses, pharmacology, and toxicology of Astragalus to explore the potential of Huangqi and expand its applications. Data were obtained from databases such as PubMed, CNKI, Wan Fang Data, Baidu Scholar, and Google Scholar. The collected material also includes classic works of Chinese herbal medicine, Chinese Pharmacopoeia, Chinese Medicine Dictionary, and PhD and Master’s theses. The pharmacological effects of the isoflavone fraction in Huangqi have been studied extensively; The pharmacological effects of Huangqi isoflavone are mainly reflected in its anti-inflammatory, anti-tumor, anti-oxidant, anti-allergic, and anti-diabetic properties and its ability to treat several related diseases. Additionally, the medicinal uses, chemical composition, pharmacological activity, toxicology, and quality control of Huangqi require further elucidation. Here, we provide a comprehensive review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of Astragalus to assist future innovative research and to identify and develop new drugs involving Huangqi.
Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway
Authors: Chandrasekaran Ravishankar , Morris Carolyn R. , Butzirus Isabella M. , Mark Zoe F. , Kumar Amit , Souza De Lima Dhemerson , Daphtary Nirav , Aliyeva Minara , Poynter Matthew E. , Anathy Vikas , Dixon Anne E.
Published: August 2023

Obesity is a risk factor for severe influenza, and asthma exacerbations caused by respiratory viral infections. We investigated mechanisms that increase the severity of airway disease related to influenza in obesity using cells derived from obese and lean individuals, and in vitro and in vivo models. Primary human nasal epithelial cells (pHNECs) derived from obese compared with lean individuals developed increased inflammation and injury in response to influenza A virus (IAV). Obese mice infected with influenza developed increased airway inflammation, lung injury and elastance, but had a decreased interferon response, compared with lean mice. Lung arachidonic acid (AA) levels increased in obese mice infected with IAV; arachidonic acid increased inflammatory cytokines and injury markers in response to IAV in human bronchial epithelial (HBE) cells. Obesity in mice, and AA in HBE cells, increased activation of p38 MAPK signaling following IAV infection; inhibiting this pathway attenuated inflammation, injury and tissue elastance responses, and improved survival. In summary, obesity increases disease severity in response to influenza infection through activation of the p38 MAPK pathway in response to altered arachidonic acid signaling.
Impact of continuous pharmaceutical care led by clinical pharmacists during transitions of care on medication adherence and clinical outcomes for patients with coronary heart disease: a prospective cohort study
Authors: Gao Lingyan , Han Yalei , Jia Zhankun , Wang Pengfei , Zhang Meijing , Ma Teng , Yan Suying , Liu Hua
Published: August 2023

Objectives: The study aimed to explore the impact of a continuous pharmaceutical care (CPC) program during care transitions on medication adherence and clinical outcomes for patients with coronary heart disease (CHD).

Methods: A prospective cohort study was conducted from April 2020 to February 2021. Patients diagnosed with CHD were selected and divided into intervention (CPC) and usual care (UC) groups by nurses at equal intervals based on admission time. The intervention group received CPC services provided by clinical pharmacists (including medication reconciliation, disease education, medication guidance, lifestyle counseling, and follow-up services) and usual care. The UC group received only routine medical care. The study compared medication adherence, clinical indicators (low-density lipoprotein cholesterol [LDL-C], blood pressure [BP], glycated hemoglobin [HbA1c] control rates), the incidence of adverse drug reactions (ADRs), and readmission rates (overall, major adverse cardiovascular events [MACEs]-related, and CHD risk factors-related) at admission and 1, 3, and 6 months after discharge between the two groups.

Results: A total of 228 patients with CHD completed the study, including 113 patients in the CPC group and 115 patients in the UC group. There were no significant differences (p > 0.05) in both groups in demographic and clinical characteristics at baseline. A total of 101 drug-related problems were identified in the CPC group (an average of 0.89 per person). The CPC group showed significantly higher medication adherence at 1, 3, and 6 months after discharge than the UC group (p < 0.05). At 3 and 6 months after discharge, the intervention group had significantly higher control rates of LDL-C (61.11% vs. 44.64% at 3 months, 78.18% vs. 51.43% at 6 months), and BP (91.15% vs. 77.39% at 3 months, 88.50% vs. 77.19% at 6 months). The CPC group had higher HbA1c control rates (53.85% vs. 34.21% at 3 months, 54.05% vs. 38.46% at 6 months) than the UC group. However, the differences were not statistically significant. The incidence of ADRs 6 months after discharge was significantly lower in the CPC group than in the UC group (5.13% vs. 12.17%, p < 0.05). The CPC group had a lower overall readmission rate (13.27% vs. 20.00%), MACE-related readmission rate (5.31% vs. 12.17%), and readmission rate related to CHD risk factors (0.88% vs. 2.61%) 6 months after discharge compared to the UC group. However, these differences were not statistically significant (p > 0.05).

Conclusion: CPC led by clinical pharmacists during care transitions effectively improved medication adherence, safety, and risk factor control in patients with CHD.
Thin films of silicon nitride deposited at room temperature by non-reactive magnetron sputtering: radiofrequency power and deposition time influence on the formation of α-Si3N4 and its optical properties
Authors: Barrera-Mendivelso Edwin Sebastian , Rodríguez-Gómez Arturo
Published: August 2023

Silicon nitride’s excellent electronic and optical properties have positioned it as an indispensable element in silicon-based photonic platforms and photonic quantum computing. Chemical Vapor Deposition (CVD) and Plasma Enhanced CVD (PECVD) techniques predominate in high-performance silicon nitride thin film manufacture. Unfortunately, Chemical Vapor Deposition and Plasma Enhanced CVD are expensive techniques that use hazardous gases and very high substrate temperatures. In this work, we used the sputtering technique to grow α-Si3N4 thin films at room temperature. We identified that by applying radiofrequency powers between 30 and 50 W combined with deposition times below 120 min, we could achieve the growth of silicon nitride (SiNX) films with uniformly distributed crystalline particles, limited formation of clusters, and minimal alterations in atomic ordering. The Volmer-Weber model governs the film’s growth, which favors its continuity and surface roughness. The optical bandgaps of our SiNX films ranged from 2.3 to 3.9 eV, and their RMS roughness never exceeded 4 nm. We observed a quasi-linear deposition rate concerning radiofrequency power and deposition time, whereby we were able to grow SiNX films controllably and reproducibly with thicknesses ranging from 45 to 500 nm.
Contactless photoplethysmography for assessment of small fiber neuropathy
Authors: Marcinkevics Zbignevs , Rubins Uldis , Aglinska Alise , Logina Inara , Glazunovs Dmitrijs , Grabovskis Andris
Published: August 2023

Chronic pain is a prevalent condition affecting approximately one-fifth of the global population, with significant impacts on quality of life and work productivity. Small fiber neuropathies are a common cause of chronic pain, and current diagnostic methods rely on subjective self-assessment or invasive skin biopsies, highlighting the need for objective noninvasive assessment methods. The study aims to develop a modular prototype of a contactless photoplethysmography system with three spectral bands (420, 540, and 800 nm) and evaluate its potential for assessing peripheral neuropathy patients via a skin topical heating test and spectral analyses of cutaneous flowmotions. The foot topical skin heating test was conducted on thirty volunteers, including fifteen healthy subjects and fifteen neuropathic patients. Four cutaneous nerve fiber characterizing parameters were evaluated at different wavelengths, including vasomotor response trend, flare area, flare intensity index, and the spectral power of cutaneous flowmotions. The results show that neuropathic patients had significantly lower vasomotor response (50%), flare area (63%), flare intensity index (19%), and neurogenic component (54%) of cutaneous flowmotions compared to the control group, independent of photoplethysmography spectral band. An absolute value of perfusion was 20%–30% higher in the 420 nm band. Imaging photoplethysmography shows potential as a cost-effective alternative for objective and non-invasive assessment of neuropathic patients, but further research is needed to enhance photoplethysmography signal quality and establish diagnostic criteria.
Identification of Fusarium head blight sources of resistance and associated QTLs in historical and modern Canadian spring wheat
Authors: Semagn Kassa , Henriquez Maria Antonia , Iqbal Muhammad , Brûlé-Babel Anita L. , Strenzke Klaus , Ciechanowska Izabela , Navabi Alireza , N’Diaye Amidou , Pozniak Curtis , Spaner Dean
Published: August 2023

Fusarium head blight (FHB) is one the most globally destructive fungal diseases in wheat and other small grains, causing a reduction in grain yield by 10–70%. The present study was conducted in a panel of historical and modern Canadian spring wheat (Triticum aestivum L.) varieties and lines to identify new sources of FHB resistance and map associated quantitative trait loci (QTLs). We evaluated 249 varieties and lines for reaction to disease incidence, severity, and visual rating index (VRI) in seven environments by artificially spraying a mixture of four Fusarium graminearum isolates. A subset of 198 them were genotyped with the Wheat 90K iSelect single nucleotide polymorphisms (SNPs) array. Genome-wide association mapping performed on the overall best linear unbiased estimators (BLUE) computed from all seven environments and the International Wheat Genome Sequencing Consortium (IWGSC) RefSeq v2.0 physical map of 26,449 polymorphic SNPs out of the 90K identified sixteen FHB resistance QTLs that individually accounted for 5.7–10.2% of the phenotypic variance. The positions of two of the FHB resistance QTLs overlapped with plant height and flowering time QTLs. Four of the QTLs (QFhb.dms-3B.1, QFhb.dms-5A.5, QFhb.dms-5A.7, and QFhb.dms-6A.4) were simultaneously associated with disease incidence, severity, and VRI, which accounted for 27.0–33.2% of the total phenotypic variance in the combined environments. Three of the QTLs (QFhb.dms-2A.2, QFhb.dms-2D.2, and QFhb.dms-5B.8) were associated with both incidence and VRI and accounted for 20.5–22.1% of the total phenotypic variance. In comparison with the VRI of the checks, we identified four highly resistant and thirty-three moderately resistant lines and varieties. The new FHB sources of resistance and the physical map of the associated QTLs would provide wheat breeders valuable information towards their efforts in developing improved varieties in western Canada.
A molecular framework for lc controlled locule development of the floral meristem in tomato
Authors: Xiang Hengzuo , Meng Sida , Ye Yunzhu , Han Leilei , He Yi , Cui Yiqing , Tan Changhua , Ma Jian , Qi Mingfang , Li Tianlai
Published: August 2023

Malformed tomato fruit with multiple locules is a common physiological disorder that significantly affects the quality of tomatoes. Research has shown that the occurrence of malformed fruit in tomatoes is closely linked to the number of locules, and two key QTLs, lc and fas, are involved in controlling this trait. It has been observed that lc has a relatively weaker effect on increasing locule number, which is associated with two SNPs in the CArG repressor element downstream of the SlWUS. However, the precise molecular mechanism underlying lc is not yet fully understood. In this study, we investigated the role of lc in tomato locule development. We found that the number of floral organs and fruit locules significantly increased in tomato lc knockout mutants. Additionally, these mutants showed higher expression levels of the SlWUS during carpel formation. Through cDNA library construction and yeast one-hybrid screening, we identified the MADS-box transcription factor SlSEP3, which was found to bind to lc. Furthermore, we observed an increase in floral organs and fruit locules similar to the lcCR plant on SlSEP3 silencing plants. However, it should be noted that the lc site is located after the 3′ untranslated region (UTR) of SlWUS in the tomato genome. As a result, SlSEP3 may not be able to exert regulatory functions on the promoter of the gene like other transcription factors. In the yeast two-hybrid assay, we found that several histone deacetylases (SlHDA1, SlHDA3, SlHDA4, SlHDA5, SlHDA6, SlHDA7, and SlHDA8) can interact with SlSEP3. This indicated that SlSEP3 can recruit these proteins to repress nucleosome relaxation, thereby inhibiting SlWUS transcription and affecting the number of locules in tomato fruit. Therefore, our findings reveal a new mechanism for lc playing a significant role in the genetic pathway regulating tomato locule development.
A cultural training for the improvement of cognitive and affective Theory of Mind in people with Multiple Sclerosis: a pilot randomized controlled study
Authors: d’Arma Alessia , Valle Annalisa , Massaro Davide , Baglio Gisella , Isernia Sara , Di Tella Sonia , Rovaris Marco , Baglio Francesca , Marchetti Antonella
Published: August 2023

Theory of Mind (ToM), the ability to understand and attribute mental states to ourselves and others, could be impaired in Multiple Sclerosis (MS), a neurodegenerative disease affecting young adults. Considering that ToM is strictly connected to Quality of Life (QoL) in MS and that could enhance the social support network -which is particularly important for this population-, we aimed to design and implement a novel ToM rehabilitation training. To make the training as much ecological as possible, we have devised a protocol enhancing ToM through stimuli depicting real-world conditions (video-clips taken from cinema movies, literary fictions, and audio voices). We test training’s effect on both cognitive and affective components of ToM in a sample of 13 subjects, randomly assigned to the ToM training Group and to the Control Group. The following ToM tasks were administered: the Reading the Mind in the Eyes (RMET), the Strange Stories task, the Faux Pas Task and the False Belief First- and Second - Order Task (FB II and III order). We also administered a psycho-behavioral assessment through the Toronto Alexithymia Scale (TAS-20). Results show that our novel ToM training is useful in enhancing ToM abilities measured by the following tasks: the RMET (affective task, p = 0.015) and the FB II-order task (FB, cognitive task, p = 0.032). Our ToM training had also a significant effect on the total score of the TAS-20 Scale (p = 0.018) and on its “Difficulty Describing Feelings subscale” (p = 0.018), indicating a reduction of the alexithymia traits. Future works with larger samples could investigate the ToM training effectiveness in a more representative MS populations.
Missed a live match? Determinants of League of Legends Champions Korea highlights viewership
Authors: Ryu Yoonji , Hwang Hui , Jeong Jaehyun , Jang Wonseok , Lee Gyemin , Pyun Hyunwoong
Published: August 2023

This research aims to explore the determinants of the League of Legends Champions Korea (LCK) highlight views and comment counts. The data of 629 game highlight views and comment counts for seven tournaments were collected from YouTube. The highlight views and comment counts were regressed on a series of before-the-game factors (outcome uncertainty and game quality), after-the-game factors (sum and difference of kills, assists, multiple kills, and upset results), and match-related characteristics (game duration, evening game, and clip recentness). A multi-level least square dummy variable regression was conducted to test the model. Among the before-the-game factors, outcome uncertainty and game quality were significantly associated with highlight views and comment counts. This indicated that fans liked watching games with uncertain outcomes and those involving high-quality teams. Among the after-the-game factors, an upset result was a significant determinant of esports highlight views and comment counts. Thus, fans enjoy watching underdogs win. Finally, the sum of kills and assists only affected view counts, which indicated that fans prefer watching offensive games with more kills and a solo performance rather than teamwork.
“The facilitator is not a bystander”: exploring the perspectives of interdisciplinary experts on trauma research
Authors: Hira Sarita , Sheppard-Perkins Madeleine , Darroch Francine E.
Published: August 2023

Objective

This study investigates the concepts, knowledge, and guiding principles that inform the practice of professionals researching trauma or working directly with individuals who have lived and living experiences of trauma. These aspects are explored with the aim of identifying current practices and potential gaps which may contribute to more trauma-informed biomarker-based research approaches.

Method

The perspectives of experts were explored through semi-structured interviews with seven participants; these individuals represented trauma research, clinical practice, and trauma-informed physical activity domains.

Results

A thematic analysis of the collected data revealed three focal areas highlighted by participants from all disciplines: “If I want to know trauma in the body of a person I need to know the person’s language” which related to experiences of discussing trauma with clients; “What all people need is a safe place” relayed the importance of safety for participants working with the trauma expert; and “the facilitator is not a bystander” framing trauma-related work as a collaborative process between participants and their care providers.

Conclusion

Evidence of formal implementation of trauma-informed practices within research settings is lacking. This gap is identified within background literature, while the importance of implementing these practices is emphasized by the participants of this study. This presents an opportunity to apply the insights of the interviewed experts toward advancing trauma research methodologies. Adapting biomarker-based research methodologies to fit a trauma- and violence-informed model may have benefits for the quality of participant experiences, research data, and knowledge of effective interventions.
Lateralization difference in functional activity during Stroop tasks: a functional near-infrared spectroscopy and EEG simultaneous study
Authors: Chen Zemeng , Ji Xiang , Li Ting , Gao Chenyang , Li Guorui , Liu Shuyu , Zhang Yingyuan
Published: August 2023

Introduction

Conflict monitoring and processing is an important part of the human cognitive system, it plays a key role in many studies of cognitive disorders.

Methods

Based on a Chinese word-color match Stroop task, which included incongruent and neutral stimuli, the Electroencephalogram (EEG) and functional Near-infrared Spectroscopy (fNIRS) signals were recorded simultaneously. The Pearson correlation coefficient matrix was calculated to analyze brain connectivity based on EEG signals. Granger Causality (GC) method was employed to analyze the effective connectivity of bilateral frontal lobes. Wavelet Transform Coherence (WTC) was used to analyze the functional connectivity of the bilateral hemisphere and ipsilateral hemisphere.

Results

Results indicated that brain connectivity analysis on EEG signals did not show any significant lateralization, while fNIRS analysis results showed the frontal lobes especially the left frontal lobe play the leading role in dealing with conflict tasks. The human brain shows leftward lateralization while processing the more complicated incongruent stimuli. This is demonstrated by the higher functional connectivity in the left frontal lobe and the information flow from the left frontal lobe to the right frontal lobe.

Discussion

Our findings in brain connectivity during cognitive conflict processing demonstrated that the dual modality method combining EEG and fNIRS is a valuable tool to excavate more information through cognitive and physiological studies.
Research on digital tool in cognitive assessment: a bibliometric analysis
Authors: Chen Leian , Zhen Weizhe , Peng Dantao
Published: August 2023

Objective

The number of research into new cognitive assessment tools has increased rapidly in recent years, sparking great interest among professionals. However, there is still little literature revealing the current status and future trends of digital technology use in cognitive assessment. The aim of this study was to summarize the development of digital cognitive assessment tools through the bibliometric method.

Methods

We carried out a comprehensive search in the Web of Science Core Collection to identify relevant papers published in English between January 1, 2003, and April 3, 2023. We used the subjects such as “digital,” “computer,” and “cognitive,” and finally 13,244 related publications were collected. Then we conducted the bibliometric analysis by Bibliometrix” R-package, VOSviewer and CiteSpace software, revealing the prominent countries, authors, institutions, and journals.

Results

11,045 articles and 2,199 reviews were included in our analyzes. The number of annual publications in this field was rising rapidly. The results showed that the most productive countries, authors and institutions were primarily located in economically developed regions, especially the North American, European, and Australian countries. Research cooperation tended to occur in these areas as well. The application of digital technology in cognitive assessment appealed to growing attention during the outbreak of the COVID-19 epidemic.

Conclusion

Digital technology uses have had a great impact on cognitive assessment and health care. There have been substantial papers published in these areas in recent years. The findings of the study indicate the great potential of digital technology in cognitive assessment.
Machine vs. human, who makes a better judgment on innovation? Take GPT-4 for example
Authors: Du Mark
Published: August 2023

Introduction

Human decision-making is a complex process that is often influenced by various external and internal factors. One such factor is noise, random, and irrelevant influences that can skew outcomes.

Methods

This essay uses the CAT test and computer simulations to measure creativity.

Results

Evidence indicates that humans are intrinsically prone to noise, leading to inconsistent and, at times, inaccurate decisions. In contrast, simple rules demonstrate a higher level of accuracy and consistency, while artificial intelligence demonstrates an even higher capability to process vast data and employ logical algorithms.

Discussion

The potential of AI, particularly its intuitive capabilities, might be surpassing human intuition in specific decision-making scenarios. This raises crucial questions about the future roles of humans and machines in decision-making spheres, especially in domains where precision is paramount.
Effects of repetitive low-acceleration impacts on attitude estimation with micro-electromechanical inertial measurement units
Authors: Allione Federico , Gamba Juan D. , Gkikakis Antonios E. , Featherstone Roy , Caldwell Darwin
Published: August 2023

Inertial Measurement Units are present in several applications in aerospace, unmanned vehicle navigation, legged robots, and human motion tracking systems, due to their ability to estimate a body’s acceleration, orientation and angular rate. In contrast to rovers and drones, legged locomotion involves repeated impacts between the feet and the ground, and rapid locomotion (e.g., running) involves alternating stance and flight phases, resulting in substantial oscillations in vertical acceleration. The aim of this research is to investigate the effects of periodic low-acceleration impacts (4 g, 8 g and 16 g), which imitate the vertical motion of a running robot, on the attitude estimation of multiple Micro-Electromechanical Systems IMUs. The results reveal the presence of a significant drift in the attitude estimation of the sensors, which can provide important information during the design process of a robot (sensor selection), or during the control phase (e.g., the system will know that after a series of impacts the attitude estimations will be inaccurate).
Deep learning model of hiss waves in the plasmasphere and plumes and their effects on radiation belt electrons
Authors: Huang Sheng , Li Wen , Ma Qianli , Shen Xiao-Chen , Capannolo Luisa , Hanzelka Miroslav , Chu Xiangning , Ma Donglai , Bortnik Jacob , Wing Simon
Published: August 2023

Hiss waves play an important role in removing energetic electrons from Earth’s radiation belts by precipitating them into the upper atmosphere. Compared to plasmaspheric hiss that has been studied extensively, the evolution and effects of plume hiss are less understood due to the challenge of obtaining their global observations at high cadence. In this study, we use a neural network approach to model the global evolution of both the total electron density and the hiss wave amplitudes in the plasmasphere and plume. After describing the model development, we apply the model to a storm event that occurred on 14 May 2019 and find that the hiss wave amplitude first increased at dawn and then shifted towards dusk, where it was further excited within a narrow region of high density, namely, a plasmaspheric plume. During the recovery phase of the storm, the plume rotated and wrapped around Earth, while the hiss wave amplitude decayed quickly over the nightside. Moreover, we simulated the overall energetic electron evolution during this storm event, and the simulated flux decay rate agrees well with the observations. By separating the modeled plasmaspheric and plume hiss waves, we quantified the effect of plume hiss on energetic electron dynamics. Our simulation demonstrates that, under relatively quiet geomagnetic conditions, the region with plume hiss can vary from L = 4 to 6 and can account for up to an 80% decrease in electron fluxes at hundreds of keV at L > 4 over 3 days. This study highlights the importance of including the dynamic hiss distribution in future simulations of radiation belt electron dynamics.
Evaluation of a novel chlorine dioxide-based packaging technology to reduce human enteric virus contamination on refrigerated tomatoes and blueberries
Authors: Goulter Rebecca M. , Frye Jason W. , Kerr William L. , Richard Angela , Johnston Michael , Jaykus Lee-Ann
Published: August 2023

Introduction

Chlorine dioxide (ClO2) is a promising antimicrobial with various food applications, one of those being inclusion in packaging. The purpose of this study was to evaluate a novel ClO2-based antimicrobial packaging system (InvisiShield™) for its efficacy against human norovirus (hNoV) and hepatitis A virus (HAV) in refrigerated fresh produce.

Methods

Grape tomatoes or blueberries were placed in polypropylene trays and selectively inoculated with 6.0 log10 hNoV Genome Equivalent Copies (GEC; 20% stool suspension) or 6.2 log10 HAV GEC (cell culture lysate). Trays were heat sealed with a three-phase polymer film consisting of a base, channeling agent, and the ClO2 active (treatment); or control (no active) film and stored at 7°C for 24, 48 h, and 7 days. At each timepoint, the product was collected and processed for virus concentration using the sequential steps of elution and polyethylene glycol precipitation. Viruses in extracts were quantified using RNase-RT-qPCR.

Results and discussion

Log10 reductions (LR) in hNoV GEC for tomatoes were 2.2 ± 1.3, 2.9 ± 0.7, and 3.6 ± 0.3, after 24, 48 h and 7 days, respectively. For blueberries, hNoV LR were 1.4 ± 0.7, 1.7 ± 0.5, and 2.7 ± 0.2 GEC, respectively. Hepatitis A virus GEC LR were 0.4 ± 0.2, 1.0 ± 0.1, and 2.1 ± 0.7 for tomatoes, and 0.1 ± 0.2, 1.2 ± 0.4, and 3.2 ± 0.2 for blueberries, after 24, 48 h and 7 days, respectively. Position of the fruit in the tray did not affect inactivation (p > 0.05). Sensory analysis on the treated tomato products revealed no statistically significant difference in appearance, flavor and texture attributes compared to the control. This novel ClO2-based antimicrobial packaging system effectively reduced concentrations of hNoV and HAV, as evaluated using reduction in GEC as proxy for infectivity, on grape tomatoes and blueberries after one day, with efficacy improving over 7 days of refrigerated storage. This technology shows promise as an antiviral treatment as applied to refrigerated fresh produce items.
Integrated systems improve the sustainability of soybean cultivation in the tropical region
Authors: e Silva João Antônio Gonçalves , Costa Kátia Aparecida de Pinho , da Silva Luciana Maria , Severiano Eduardo da Costa , Silva Fabiano Guimarães , Habermann Eduardo , Martinez Carlos Alberto , Vilela Lourival , da Silva Alessandro Guerra , Costa Adriano Carvalho , Costa João Victor Campos Pinho , de Oliveira Katryne Jordana
Published: August 2023

Inter-cropping between annual crops with tropical forages through integration crop-livestock systems (ICL) is considered a sustainable option to increase crop diversity and soybean productivity. In this study, we evaluated (1) the biomass production, desiccation efficiency, nutrient accumulation, and biomass decomposition of soil crop residues produced by Panicum maximum plants intercropped with maize in two different sowing methods during the second harvest and (2) investigated how soil crop residues impact the productivity of soybean. The experiment was conducted in a complete block design with three replicates. We compared conventional soybean cultivation with soybean cultivated over soil crop residues produced by a previous integration between maize and two Panicum maximum cultivars: Tamani and Zuri guinea grass, within and between rows of maize plants. Our results showed that Tamani guinea grass showed the highest desiccation efficiency. Zuri and Tamani guinea grass cultivated within and between maize plants resulted in higher biomass production and nutrient cycling potential, resulting in an increase of 28.4% in soybean productivity, compared to soybean grown without soil crop residues. We concluded that ICL system is an efficient method to increase the sustainability of soybean cultivation.
A Reinforcing-Learning-Driven Artificial Bee Colony Algorithm for Scheduling Jobs and Flexible Maintenance under Learning and Deteriorating Effects
Authors: Touafek Nesrine , Benbouzid-Si Tayeb Fatima , Ladj Asma
Published: August 2023

In the last decades, the availability constraint as well as learning and deteriorating effects were introduced into the production scheduling theory to simulate real-world case studies and to overcome the limitation of the classical models. To the best of our knowledge, this paper is the first in the literature to address the permutation flowshop scheduling problem (PFSP) with flexible maintenance under learning and deterioration effects to minimize the makespan. Firstly, we address the PFSP with flexible maintenance and learning effects. Then, the deteriorating effect is also considered. Adaptive artificial bee colony algorithms (ABC) enhanced with Q-learning are proposed, in which the Nawaz–Enscore–Ham (NEH) heuristic and modified NEH heuristics are hybridized with a maintenance insertion heuristic to construct potential integrated initial solutions. Furthermore, a Q-learning (QL)-based neighborhood selection is applied in the employed bees phase to improve the quality of the search space solutions. Computational experiments performed on Taillard’s well-known benchmarks, augmented with both prognostic and health management (PHM) and maintenance data, demonstrate the effectiveness of the proposed QL-driven ABC algorithms.
Inferring Drumhead Damping and Tuning from Sound Using Finite Difference Time Domain (FDTD) Models
Authors: Alexandraki Chrisoula , Starakis Michael , Zervas Panagiotis , Bader Rolf
Published: August 2023

Percussionists use a multitude of objects and materials, mounted on their instruments, to achieve a satisfying sound texture. This is a tedious process as there are no guidelines suggesting how to manipulate a percussion instrument to adjust its perceptual characteristics in the desired direction. To this end, the article presents a methodology for computationally identifying how to damp and tune a drumhead by adjusting its mass distribution, e.g., by applying malleable paste on its surface. A dataset of 11,114 sounds has been synthesized using a FDTD solution of the wave equation representing the vibration of a membrane, which is being transmuted through the application of paste. These sounds are investigated to derive conclusions concerning their spectral characteristics and data reduction techniques are used to investigate the feasibility of computationally inferring damping parameters for a given sound. Furthermore, these sounds are used to train a Convolutional Neural Network to infer mass distribution from sound. Results show that computational approaches can provide valuable information to percussionists striving to adjust their personal sound. Although this study has been performed with synthesized sounds, the research methodology presents some inspiring ideas for future investigations with prerecorded sounds.
Dynamic Modeling and Passivity-Based Control of an RV-3SB Robot
Authors: Cardona Manuel , Serrano Fernando E. , García Cena Cecilia E.
Published: August 2023

This paper shows the dynamic modeling and design of a passivity-based controller for the RV-3SB robot. Firstly, the dynamic modeling of a Mitsubishi RV-3SB robot is conducted using Euler–Lagrange formulation in order to obtain a decoupled dynamic model, considering the actuator orientation besides the position of the analyzed robot. It is important to remark that the dynamic model of the RV-3SB robot is conducted based on kinematic model obtention, which is developed by the implementation of screw theory. Then, the passivity-based controller is obtained by separating the end effector variables and the actuator variables by making an appropriate coordinate transformation. The passivity-based controller is obtained by selecting an appropriate storage function, and by using Lyapunov theory, the passivity-based control law is obtained in order to drive the error variable, which is the difference between the measured end effector position variable and the desired end effector position variable. The passivity-based controller makes the error variable reach the origin in finite time, taking into consideration the dissipation properties of the proposed controller in order to stabilize the desired end effector position. A numerical simulation experiment is performed in order to validate the theoretical results obtained in this research. Using numerical experimentation, it is verified that the proposed control strategy is efficient and effective in driving the error variable to the origin in comparison with other modified techniques found in the literature. Finally, an appropriate discussion and conclusion of this research study are provided.
Swine Manure Reduces Nitrous Oxide Emissions from Acidic Red Soil Due to Mineral N Immobilization and Alleviated Acidification
Authors: Zhang Lu , Ren Tusheng , Li Jiwen , Adare Kiya , Daba Nano Alemu , Alam Md Ashraful , Wen Shilin , Zhang Huimin
Published: August 2023

Swine manure is widely used for ameliorating red soil acidification, but little information is available about its effect on N2O emissions. To explore the effects, a 35-day incubation experiment was conducted with two soils under different fertilization history: chemical fertilizers only (F) and combination of chemical fertilizers with swine manure (M). The treatments included no fertilizer (control), 100% N from urea (M0), and urea plus swine manure, which supplied 20% (M20), 40% (M40), 60% (M60), and 100% (M100) of total N. Soil N2O emission rates, pH, exchangeable acidity, mineral N species, dissolved organic carbon and nitrogen, microbial biomass carbon, and their inner relationships were examined. The N2O emission rates markedly increased following the treatments, reached peaks before day 2, and thereafter decreased sharply to the level of the control by day 25, 25, 23, 15, and 9 in F soil and by day 25, 25, 23, 19, and 11 in M soil for M0, M20, M40, M60, and M100 treatments, respectively. As swine manure application rate increased, the cumulative N2O emissions of F soil decreased significantly, while, for M soil, there was no significant difference among M0, M20, M40, and M60 treatments, which were higher than the M100 treatment. At the end of incubation, soil pH in F and M soils followed the order M0 < M20 < M40 < M60 < control < M100 and vice versa for exchangeable Al3+ and acidity. F soil had relatively higher NH4+-N concentration in M0 treatment and higher NO3−-N concentrations in M0 and M20 treatments than M soil. Soil pH and NH4+-N had the greatest relative contribution to N2O emissions. Overall, this study indicates that partial chemical N replacement by swine manure could effectively mitigate N2O emissions from acidic red soil primarily because of mineral N immobilization and alleviated red soil acidification. Thus, swine manure has the potential to co-ameliorate red soil acidification and N2O emission. Further research is needed to determine the effect of swine manure on N2O emission reductions under field conditions and the overall benefit in effective N management.
Solid-State Fermentation as Green Technology to Improve the Use of Plant Feedstuffs as Ingredients in Diets for European Sea Bass (Dicentrarchus labrax) Juveniles
Authors: Vieira Lúcia , Filipe Diogo , Amaral Diogo , Magalhães Rui , Martins Nicole , Ferreira Marta , Ozorio Rodrigo , Salgado José , Belo Isabel , Oliva-Teles Aires , Peres Helena
Published: August 2023

This study aimed to evaluate the utilization by juvenile European sea bass of a SSFed PF mixture with Aspergillus niger CECT 2088. A 22-day digestibility and a 50-day growth trial were performed testing four diets, including 20 or 40% of an unfermented or SSFed PF mixture (rapeseed, soybean, rice bran, and sunflower seed meals, 25% each). SSF of the PF added cellulase and β-glucosidase activity to the diets. Mycotoxin contamination was not detected in any of the experimental diets except for residual levels of zearalenone and deoxynivalenol (100 and 600 times lower than that established by the European Commission Recommendation-2006/576/EC). In diets including 20% PF, SSF did not affect growth but increased apparent digestibility coefficients of protein and energy, feed efficiency, and protein efficiency ratio. On the contrary, in diets including 40% PF, SSF decreased growth performance, feed intake, feed and protein efficiency, and diet digestibility. SSF decreased the intestinal amylase activity in the 40% SSFed diet, while total alkaline proteases decreased in the 20% and 40% SSFed diets. Hepatic amino acid catabolic enzyme activity was not modulated by SSF, and plasma total protein, cholesterol, and triglyceride levels were similar among dietary treatments. In conclusion, dietary inclusion of moderate levels of the SSFed PF, up to 20%, improves the overall feed utilization efficiency without negatively impacting European sea bass growth performance. The replacement of PF with the SSFed PF mixture may contribute to reducing the environmental footprint of aquaculture production.
Understanding the Motivations of Foster Caregivers at Animal Shelters
Authors: Ackerman Roxy , Watson Brittany , Serpell James , Reinhard Chelsea L. , Powell Lauren
Published: August 2023

Foster care programs in animal shelters have been shown to benefit animals and shelters, but little is known about what motivates foster caregivers to volunteer. This cross-sectional study explored the motivations and expectations of 131 foster caregivers from five shelters within the United States who completed a pre-foster survey between March 2022 and March 2023. The most common motivations were animal- or community-based, such as the desire to provide an animal with love or do something positive for the community. Ordinal logistic regression models were used to investigate associations between caregivers’ motivations and their prior foster experience, pet ownership history, age, gender, and foster animal species. The 18- to 29-year-old caregivers were most likely to expect companionship (OR 5.18, 95% CI 1.79–15.04), emotional support (OR 4.25, 95% CI 1.40–12.89), and to meet other community members through fostering (OR 5.04, 95% CI 1.85–13.74). Male caregivers were less likely to foster for emotional support than females (OR 0.12, 95% CI 0.03–0.48), while dog caregivers (OR 2.23, 95% CI 1.04–4.76) and non-pet-owners (OR 2.66, 95% CI 1.17–6.05) had greater odds of expecting companionship. This study highlights the importance of animal- and community-related benefits for foster caregivers and provides useful direction for shelters wanting to increase recruitment to expand their foster care programs.
Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function
Authors: Balakrishnan Rekha , Garcia Pablo A. , Veluthakal Rajakrishnan , Huss Janice M. , Hoolachan Joseph M. , Thurmond Debbie C.
Published: August 2023

The p21-activated kinase 1 (PAK1) is required for insulin-stimulated glucose uptake in skeletal muscle cells. However, whether PAK1 regulates skeletal muscle mitochondrial function, which is a central determinant of insulin sensitivity, is unknown. Here, the effect of modulating PAK1 levels (knockdown via siRNA, overexpression via adenoviral transduction, and/or inhibition of activation via IPA3) on mitochondrial function was assessed in normal and/or insulin-resistant rat L6.GLUT4myc and human muscle (LHCN-M2) myotubes. Human type 2 diabetes (T2D) and non-diabetic (ND) skeletal muscle samples were also used for validation of the identified signaling elements. PAK1 depletion in myotubes decreased mitochondrial copy number, respiration, altered mitochondrial structure, downregulated PGC1α (a core regulator of mitochondrial biogenesis and oxidative metabolism) and PGC1α activators, p38 mitogen-activated protein kinase (p38MAPK) and activating transcription factor 2 (ATF2). PAK1 enrichment in insulin-resistant myotubes improved mitochondrial function and rescued PGC1α expression levels. Activated PAK1 was localized to the cytoplasm, and PAK1 enrichment concurrent with p38MAPK inhibition did not increase PGC1α levels. PAK1 inhibition and enrichment also modified nuclear phosphorylated-ATF2 levels. T2D human samples showed a deficit for PGC1α, and PAK1 depletion in LHCN-M2 cells led to reduced mitochondrial respiration. Overall, the results suggest that PAK1 regulates muscle mitochondrial function upstream of the p38MAPK/ATF2/PGC1α-axis pathway.
The Calibration Process and Setting of Image Brightness to Achieve Optimum Strain Measurement Accuracy Using Stereo-Camera Digital Image Correlation
Authors: Hagara Martin , Huňady Róbert , Lengvarský Pavol , Vocetka Michal , Palička Peter
Published: August 2023

Combining the drilling method with the digital image correlation (DIC) method is becoming more common to speed up the measurement and evaluate the strains relieved at several locations. However, to obtain the most accurate results, it is necessary to be aware of the influence of possible aspects that could adversely affect the results of the strain/stress analysis carried out using DIC. The paper describes several analyses to assess the influence of the 3D DIC system’s calibration procedure for strain/stress analysis of the specimen with a hole loaded with four different levels of tensile force. In addition, the paper also deals with the analysis of the influence of the image brightness, which was modified by changing the exposure time of the cameras. Based on the results of strain/stress analyses performed on small areas (approx. 25 × 25 mm) of a specimen with a hole by a stereo-camera DIC system, it can be concluded that both analysed factors can negatively influence the results. The most accurate results are ensured using the calibration target of very high manufacturing precision sized similarly to the field of view observed in correlation mode. The optimal image brightness is adjusted when the mean grey value of the image is from the range of 56 up to 171 with as evenly distributed image point intensities as possible.
Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study
Authors: Wilińska Justyna , Turek Artur , Rech Jakub , Janeczek Henryk , Pastusiak Małgorzata , Kordyka Aleksandra , Borecka Aleksandra , Kobielarz Magdalena , Kasperczyk Janusz
Published: August 2023

Aripiprazole (ARP) is an atypical neuroleptic used in the therapy of mental diseases such as schizophrenia. The lack of optimal adherence to an oral therapy regime creates the basis for designing ARP long-acting injections. This study aimed to use 105 °C hot melt extrusion (HME) as a formulation method for rods based on poly(d,l-lactide-co-glycolide-co-trimethylene carbonate) with a molecular weight (Mn) of 21 kDa (Td,l 21), poly(l-lactide-co-glycolide-co-trimethylene carbonate) with a Mn of 59 kDa (Tl 59), and with a Mn of 77 kDa (Tl 77). The following methods were involved in the research: NMR, DSC, XRD, HSM, FTIR, GPC, SEM, and mechanical tests. HME at 105 °C (i) ensured flow behavior for terpolymers, (ii) did not influence the terpolymers’ composition and (iii) the polymorph changes of ARP, and (iv) resulted in the changes in terpolymers’ Mn. For the rods with ARP based on Td,l 21 (Td,l 21 rod-ARP) and Tl 59 (Tl 59 rod-ARP), plasticization was noted. No drug–terpolymer interactions were revealed. No pores were observed on the surface. Due to its high flexibility and rubber character, Td,l 21 rod-ARP may be proposed for intramuscular administration, whereas Tl 59 rod-ARP, due to its higher strength and moderate stiffness, is proposed for subcutaneous administration.