bluuebunny/crossref_metadata_2025 huggingface dataset:
Regional Impacts of the Westerly Winds on Southern Ocean Mode and Intermediate Water Subduction
Authors: Downes Stephanie M. , Langlais Clothilde , Brook Jordan P. , Spence Paul
Published: September 2017

Subduction processes in the Southern Ocean transfer oxygen, heat, and anthropogenic carbon into the ocean interior. The future response of upper-ocean subduction, in the Subantarctic Mode Water (SAMW) and Antarctic Intermediate Water (AAIW) classes, is dependent on the evolution of the combined surface buoyancy forcing and overlying westerly wind stress. Here, the recently observed pattern of a poleward intensification of the westerly winds is divided into its shift and increase components. SAMW and AAIW formation occurs in regional “hot spots” in deep mixed layer zones, primarily in the southeast Indian and Pacific. It is found that the mixed layer depth responds differently to wind stress perturbations across these regional formation zones. An increase only in the westerly winds in the Indian sector steepens isopycnals and increases the local circulation, driving deeper mixed layers and increased subduction. Conversely, in the same region, a poleward shift and poleward intensification of the westerly winds reduces heat loss and increases freshwater input, thus decreasing the mixed layer depth and consequently the associated SAMW and AAIW subduction. In the Pacific sector, all wind stress perturbations lead to increases in heat loss and decreases in freshwater input, resulting in a net increase in SAMW and AAIW subduction. Overall, the poleward shift in the westerly wind stress dominates the SAMW subduction changes, rather than the increase in wind stress. The net decrease in SAMW subduction across all basins would likely decrease anthropogenic carbon sequestration; however, the net AAIW subduction changes across the Southern Ocean are overall minor.
Seeing Like the Fed: Culture, Cognition, and Framing in the Failure to Anticipate the Financial Crisis of 2008
Authors: Fligstein Neil , Stuart Brundage Jonah , Schultz Michael
Published: September 2017

One of the puzzles about the financial crisis of 2008 is why regulators, particularly the Federal Open Market Committee (FOMC), were so slow to recognize the impending collapse of the financial system and its broader consequences for the economy. We use theory from the literature on culture, cognition, and framing to explain this puzzle. Consistent with recent work on “positive asymmetry,” we show how the FOMC generally interpreted discomforting facts in a positive light, marginalizing and normalizing anomalous information. We argue that all frames limit what can be understood, but the content of frames matters for how facts are identified and explained. We provide evidence that the Federal Reserve’s primary frame for making sense of the economy was macroeconomic theory. The content of macroeconomics made it difficult for the FOMC to connect events into a narrative reflecting the links between foreclosures in the housing market, the financial instruments used to package the mortgages into securities, and the threats to the larger economy. We conclude with implications for the sociological literatures on framing and cognition and for decision-making in future crises.
Resident Documentation of Social Determinants of Health: Effects of a Teaching Tool in the Outpatient Setting
Authors: Patel Milani , Bathory Eleanor , Scholnick Jenna , White-Davis Tanya , Choi Jaeun , Braganza Sandra
Published: September 2017

Social determinants of health (SDH) significantly affect the health of children and thus, screening is important in pediatric primary care. We assessed the use of a formal social history taking tool after a 2-phase intervention. The first phase (P1) was a teaching module describing SDH and community resources and the second phase (P2) consisted of visual reminders to use the tool. Patient charts (n = 322) were reviewed pre- and postintervention. Residents had higher documentation rates of Women, Infants, and Children (WIC) program use and housing subsidies at post-P1 and at post-P(1 + 2) (WIC, P = .01 and P = .03, respectively; housing, P = .02 and P = .04, respectively), and higher documentation rates of food stamp utilization at post-P(1 + 2) ( P = .04), as compared with baseline. Implementation of a simple teaching tool in the outpatient setting enabled residents to document income benefits and housing. Further studies should be done to evaluate effective teaching methods to elicit other important SDH.
“Hi Mommy”: Parental Preferences of Greetings by Medical Staff
Authors: Wilks-Gallo Lisa , Aron Chaim Zev , Messina Catherine R.
Published: September 2017

The therapeutic alliance between pediatricians and parents begins at the initial encounter. The manner in which pediatricians greet family members influences this relationship. This study evaluated whether parents are addressed using generic titles and investigated perceptions of parents regarding how they are addressed by medical staff. Written surveys of 137 parents of pediatric inpatients collected opinions about greetings during medical encounters. Parents were asked if they have been addressed as Mom/Dad/Mommy/Daddy during past medical encounters and which generic titles they would prefer. Using a Likert-type scale, the parents’ perceptions of various salutations were assessed and compared. In this sample, 86% of parents were previously called Mom/Dad/Mommy/Daddy. Parents preferred to be addressed as Mom or Dad over other generic titles. Many disliked being addressed as Mommy/Daddy, Ma’am/Sir, or without a name, suggesting that providers should avoid the use of these salutations.
Cultural Mistrust and Health Care Utilization: The Effects of a Culturally Responsive Cognitive Intervention
Authors: Brooks Randolph T. , Hopkins Reginald
Published: September 2017

Cultural mistrust is a critical factor underlying the racial/ethnic disparity in mental health care service utilization. It was hypothesized that there would be a difference in utilization attitudes and intentions before and after exposure to a culturally responsive intervention among individuals with moderate to high levels of cultural mistrust. Two Hundred Thirty-Six students from a predominately Black university participated in this study. This experiment employed a Solomon Four Groups design to assess the effectiveness of a culturally responsive cognitive intervention to neutralize the effects of cultural mistrust on health care attitudes and health care service utilization intentions. The results showed that the intervention was effective in neutralizing cultural mistrust and improving posttest utilization attitudes and intentions among individuals who had high levels of cultural mistrust. It was also found that health care utilization attitudes and intentions were enhanced for individuals with high levels of cultural mistrust.
Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures
Authors: Coyac B.R. , Hoac B. , Chafey P. , Falgayrac G. , Slimani L. , Rowe P.S. , Penel G. , Linglart A. , McKee M.D. , Chaussain C. , Bardet C.
Published: September 2017

X-linked hypophosphatemia (XLH) is a skeletal disease caused by inactivating mutations in the PHEX gene. Mutated or absent PHEX protein/enzyme leads to a decreased serum phosphate level, which cause mineralization defects in the skeleton and teeth (osteomalacia/odontomalacia). It is not yet altogether clear whether these manifestations are caused solely by insufficient circulating phosphate availability for mineralization or also by a direct, local intrinsic effect caused by impaired PHEX activity. Here, we evaluated the local role of PHEX in a 3-dimensional model of extracellular matrix (ECM) mineralization. Dense collagen hydrogels were seeded either with human dental pulp cells from patients with characterized PHEX mutations or with sex- and age-matched healthy controls and cultured up to 24 d using osteogenic medium with standard phosphate concentration. Calcium quantification, micro–computed tomography, and histology with von Kossa staining for mineral showed significantly lower mineralization in XLH cell-seeded scaffolds, using nonparametric statistical tests. While apatitic mineralization was observed along collagen fibrils by electron microscopy in both groups, Raman microspectrometry indicated that XLH cells harboring the PHEX mutation produced less mineralized scaffolds having impaired mineral quality with less carbonate substitution and lower crystallinity. In the XLH cultures, immunoblotting revealed more abundant osteopontin (OPN), dentin matrix protein 1 (DMP1), and matrix extracellular phosphoglycoprotein (MEPE) than controls, as well as the presence of fragments of these proteins not found in controls, suggesting a role for PHEX in SIBLING protein degradation. Immunohistochemistry revealed altered OPN and DMP1 associated with an increased alkaline phosphatase staining in the XLH cultures. These results are consistent with impaired PHEX activity having local ECM effects in XLH. Future treatments for XLH should target both systemic and local manifestations.
Bivalent Histone Codes on WNT5A during Odontogenic Differentiation
Authors: Zhou Y. , Zheng L. , Li F. , Wan M. , Fan Y. , Zhou X. , Du W. , Pi C. , Cui D. , Zhang B. , Sun J. , Zhou X.
Published: September 2017

Lineage-committed differentiation is an essential biological program during odontogenesis, which is tightly regulated by lineage-specific genes. Some of these genes are modified by colocalization of H3K4me3 and H3K27me3 marks at promoter regions in progenitors. These modifications, named “bivalent domains,” maintain genes in a poised state and then resolve for later activation or repression during differentiation. Wnt5a has been reported to promote odontogenic differentiation in dental mesenchyme. However, relatively little is known about the epigenetic modulations on Wnt5a activation during tooth development. Here, we investigated the spatiotemporal patterns of H3K4me3 and H3K27me3 marks in developing mouse molars. Associated H3K4me3 methylases (mixed-lineage leukemia [MLL] complex) and H3K27me3 demethylases (JMJD3 and UTX) were dynamically expressed between early and late bell stage of human tooth germs and in cultured human dental papilla cells (hDPCs) during odontogenic induction. Poised WNT5A gene was marked by bivalent domains containing repressive marks (H3K27me3) and active marks (H3K4me3) on promoters. The bivalent domains tended to resolve during inducted differentiation, with removal of the H3K27me3 mark in a JMJD3-dependent manner. When JMJD3 was knocked down in cultured hDPCs, odontogenic differentiation was suppressed. The depletion of JMJD3 epigenetically repressed WNT5A activation by increased H3K27me3 marks. In addition, JMJD3 could physically interact with ASH2L, a component of the MLL complex, to form a coactivator complex, cooperatively modulating H3K4me3 marks on WNT5A promoters. Overall, our study reveals that transcription activities of WNT5A were epigenetically regulated by the negotiated balance between H3K27me3 and H3K4me3 marks and tightly mediated by JMJD3 and MLL coactivator complex, ultimately modulating odontogenic commitment during dental mesenchymal cell differentiation.
Rapid transit, transit-oriented development, and the contextual sensitivity of land value uplift in Toronto
Authors: Higgins Christopher , Kanaroglou Pavlos
Published: September 2017

Rapid transit projects that increase accessibility should result in a localised land value uplift (LVU) benefit for locations near stations. A rich history of research has tested this hypothesis, generally operationalising transit accessibility by proxy through distance from a transit station. However, a growing body of research has also demonstrated LVU effects from transit-oriented development (TOD) as individuals sort themselves into locations that best match their preferences and willingness to pay. Considering the interdependence of transportation and land use in the urban system, we argue that these benefits create a spatial bundle of TOD goods around transit stations and hypothesise that households are willing to pay a premium for locations in more transit-oriented station catchment areas. Utilising latent class analysis, we quantify station area TOD submarkets. Next, interactions between these submarkets and station proximity in spatial hedonic regressions reveal that TOD is capitalised into land values in Toronto, though the maximum amount and spatial impact area of this capitalisation differs by TOD context.
Systematic Review and Meta-analysis of Seizure Recurrence After a First Unprovoked Seizure in 815 Neurologically and Developmentally Normal Children
Authors: Garcia Pierce Joanna , Aronoff Stephen , Del Vecchio Michael
Published: September 2017

Limited data exist for health care providers regarding seizure recurrence after a first unprovoked seizure in previously neurologically and developmentally normal children. A systematic review and meta-analysis was conducted to assess seizure recurrence after a first unprovoked seizure by performing an electronic search in PubMed, Embase, and Scopus. Six studies from 2817 met the inclusion criteria. The sample size consisted of 815 neurologically and developmentally normal children (1 month–17.5 years) on no antiepileptic drugs. This systematic review and meta-analysis estimated a recurrence rate within 3 years of 45% (95% CI: 37%, 60%). This estimate provides a touchstone for health care providers who are managing this particular population of children.
Parents’ Spatial Language Mediates a Sex Difference in Preschoolers’ Spatial-Language Use
Authors: Pruden Shannon M. , Levine Susan C.
Published: September 2017

Do boys produce more terms than girls to describe the spatial world—that is, dimensional adjectives (e.g., big, little, tall, short), shape terms (e.g., circle, square), and words describing spatial features and properties (e.g., bent, curvy, edge)? If a sex difference in children’s spatial-language use exists, is it related to the spatial language that parents use when interacting with children? We longitudinally tracked the development of spatial-language production in children between the ages of 14 and 46 months in a diverse sample of 58 parent-child dyads interacting in their homes. Boys produced and heard more of these three categories of spatial words, which we call “what” spatial types (i.e., unique “what” spatial words), but not more of all other word types, than girls. Mediation analysis revealed that sex differences in children’s spatial talk at 34 to 46 months of age were fully mediated by parents’ earlier spatial-language use, when children were 14 to 26 months old, time points at which there was no sex difference in children’s spatial-language use.
Are circumpolar hunter-gatherers visible in the palaeoenvironmental record? Pollen-analytical evidence from Nunalleq, southwestern Alaska
Authors: Ledger Paul M
Published: September 2017

Identifying evidence for hunter-gatherers in the palaeoenvironmental record is far from simple. Despite decades of research, few studies have demonstrated unambiguous palynological evidence of hunter-gatherers. This paper presents the results of high-resolution palaeoecological analyses of a peat sequence located within the vicinity of the pre-historic Yup’ik village of Nunalleq in southwestern Alaska. The aim of this research was to examine whether there are any discernible palaeoenvironmental impacts associated with the 15th–17th century occupation of the site. Presuming an ephemeral character to any palaeoecological signal, this study selected a sampling location approximately 30 m east of the limit of archaeological remains. Pollen, non-pollen palynomorphs and microscopic charcoal analysis were then used to generate a highly resolved (contiguous 1 cm) environmental history for the site. The results are striking and indicate that the activities of prehistoric Yup’ik hunter-gatherers at Nunalleq did leave a clear material trace in the palaeoenvironmental record. Through the application of high-resolution Pb210 and C14 dating and Bayesian modelling, these impacts were found to be concurrent with the occupation of the archaeological site. These findings suggest that not only can circumpolar hunter-gatherers leave a material palaeoenvironmental trace but that these traces may be used to accurately date such site activity in lieu of excavation.
NUCKS nuclear elevated expression indicates progression and prognosis of ovarian cancer
Authors: Shi Ce , Qin Ling , Gao Hongyu , Gu Lina , Yang Chang , Liu Hebing , Liu Tianbo
Published: September 2017

NUCKS (nuclear, casein kinase, and cyclin-dependent kinase substrate) is implicated in the tumorigenesis of several human malignancies, but its role in ovarian cancer remains unknown. We aim to investigate NUCKS expression and its clinical significance in ovarian cancer. The messenger RNA expression of NUCKS was determined in normal and malignant ovarian tissues using quantitative polymerase chain reaction assay. Immunohistochemistry was applied to detect the status of NUCKS protein expression in 121 ovarian cancer tissues. NUCKS protein high expression was detected in 52 (43.0%) of 121 patients. NUCKS messenger RNA expression was gradually upregulated in non-metastatic ovarian cancers ( n = 20), metastatic ovarian cancers ( n = 20), and its matched metastatic lesions ( n = 20) in comparison with that in normal ovarian tissues ( n = 10; p < 0.05). Elevated expression of NUCKS in ovarian cancer was associated significantly with the Federation of Gynecology and Obstetrics stage ( p = 0.037), histological grade ( p = 0.003), residual disease ( p = 0.013), lymph node metastasis ( p = 0.002), response to chemotherapy ( p < 0.001), and recurrence ( p = 0.013). In the multivariate Cox analysis, NUCKS expression was an independent prognostic marker for overall survival and disease-free survival in ovarian cancer with p values of <0.001 for both. Especially, NUCKS overexpression had prognostic potential for overall survival and disease-free survival ( p < 0.001 for both) in advanced ovarian cancers and only for disease-free survival in early ovarian cancers ( p = 0.017). Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer.
How adolescents perceive that community-based exercise improves their well-being
Authors: Rourke Kevin , Wilson Coralie J
Published: September 2017

Objectives:

To determine if adolescents perceive community-based exercise as beneficial to their well-being and in what ways.

Methods:

A New South Wales Police Citizens Youth Club ran a four-week fitness course. The classes involved: 1) sports including basketball and soccer, 2) non-contact boxing drills, and 3) games, both team games such as dodgeball and non-team games such as line tag. Parental consent to offer a survey at the completion of the course was requested during registration. The survey was the Warwick Edinburgh Mental Well-being Scale; it was minimally modified to measure perceived benefit to mental well-being instead of actual benefit.

Results:

Thirty-one high school adolescents, ages 13–18, completed the survey. As a group, participants reported that they believed their well-being had improved after the course. The mean score for each survey item showed an improvement in every area of mental well-being for this sample of adolescents. Thirty-two per cent of adolescents reported having less energy. Survey scores indicated a statistically significant improvement in perceived well-being ( p<0.0001).

Conclusions:

The results of this study suggest that four weeks of community-based exercise improves perceived mental well-being in adolescent participants.
Systemic and Adjuvant Therapies for Intrahepatic Cholangiocarcinoma
Authors: Chun Yun Shin , Javle Milind
Published: September 2017

Intrahepatic cholangiocarcinoma represents the second most common primary liver cancer and is increasing in incidence. Most patients are diagnosed at an advanced, nonsurgical stage and only about 1 in 5 cases are surgically resectable. Despite surgery, the 5-year survival is low at only 30%. Multifocal, node- or margin-positive disease is at a higher risk of recurrence after resection. There is no level 1 evidence in support of postoperative adjuvant therapy. A recent adjuvant therapy phase III trial from the Partenariat de Recherche en Oncologie Digestive-Actions Concertées dans les Cancers Colo-Rectaux et Digestifs (PRODIGE) group reported no survival advantage with adjuvant gemcitabine and oxaliplatin therapy. Locally advanced or metastatic cholangiocarcinoma is treated with gemcitabine-based systemic chemotherapy with suboptimal response and survival. Integration of local therapy such as focal radiation along with induction chemotherapy is now being investigated in multicenter clinical trials. Recent molecular profiling studies have indicated that about 30% to 40% of intrahepatic cholangiocarcinoma cases have actionable mutations. These include fibroblast growth factor receptor (FGFR), isocitrate dehyrogenase 1 (IDH1), epidermal growth factor receptor (EGFR), and BRAF genetic aberrations. Clinical trials targeting these mutations as well as immune therapy using programmed cell death 1 (PD1) inhibitors indicated a promising early signal showing clinical efficacy.
Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Authors: Massarweh Nader N. , El-Serag Hashem B.
Published: September 2017

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most frequently occurring types of primary liver cancer and together are among the most common incident cancers worldwide. There are a number of modifiable and nonmodifiable HCC and ICC risk factors that have been reported. A review of the existing literature the epidemiology and risk factors for HCC and ICC was performed. There are a number of major infectious, lifestyle, metabolic, and heritable risk factors for both HCC and ICC. Some of these risk factors are either potentially preventable (eg, alcohol and tobacco use) or are currently treatable (eg hepatitis infection). In most cases, the molecular pathway or mechanism by which these etiologic factors cause primary liver cancer has not been well delineated. However, in nearly all cases, it is believed that a given risk factor causes liver injury and inflammation which results in chronic liver disease. Given the rising prevalence of several common HCC and ICC risk factors in the western world, the best opportunities for improving the care of these patients are either through the prevention of modifiable risk factors that are associated with the development of chronic liver disease or the identification of at risk patients, ensuring they are appropriately screened for the development of primary liver cancer, and initiating treatment early.
Obesity Paradox in Patients With Deep Venous Thrombosis
Authors: El-Menyar Ayman , Asim Mohammad , Al-Thani Hassan
Published: September 2017

We aimed to investigate the association between obesity and deep venous thrombosis (DVT) in a country with a high prevalence of obesity. This is a retrospective cohort study of patients who presented with DVT between 2008 and 2012. Data were analyzed and compared based on body mass index (BMI), and patients were classified into normal (<25), overweight (≥25 to <30), obese I (30 to <35), obese II (35 to <40), and obese III (≥40). Among 662 patients with DVT, 28% were overweight and 49% were obese. The mean age was 50.3 (16.5) years, and 51% were females. Diabetes mellitus and prior venous thromboembolism were significantly higher among obese patients. History of malignancy was more common in nonobese patients. Protein S and antithrombin III deficiency and hyperhomocysteinemia were more prevalent among morbid obese patients. Also, obese patients had higher incidence of thrombosis in the distal veins ( P = .03). Warfarin use and long-term therapy were more frequent in obese than nonobese. Postthrombotic syndrome was comparable in obese and nonobese groups. Recurrent DVT was higher in obese I ( P < .01), whereas mortality rates were greater in nonobese groups ( P = .001). Malignancy, diabetes mellitus, and common femoral vein involvement were predictors of mortality, whereas BMI ≥30 was the predictor of survival. Cox regression models showed that after adjusting for age, sex, pulmonary embolism, and duration of warfarin treatment, BMI ≥40 had better survival (hazard ratio: 0.177, 95% confidence interval: 0.045-0.691, P = .013). There is a significant association between obesity and DVT. Obese patients have characteristic risk factors and better survival. This obesity paradox needs further studies to assess its clinical and pharmacotherapeutic implications.
Acceptability of a Salon-Based Intervention to Promote Colonoscopy Screening Among African American Women
Authors: Floyd Tiffany D. , DuHamel Katherine N. , Rao Jessica , Shuk Elyse , Jandorf Lina
Published: September 2017

African American women have the highest colorectal cancer incidence and mortality rates among women of any race/ethnicity in the United States. Colonoscopy screening is an efficacious procedure for the prevention and early detection of colorectal cancer, making it a promising tool in the effort to eliminate colorectal cancer disparities. Toward that end, the present qualitative study sought to assess acceptability of and preferences for a beauty salon–based intervention to promote colonoscopy screening among African American women. A total of 11 focus groups were conducted: 6 with staff from African American–serving salons ( n = 3 with salon owners, n = 3 with salon stylists) and 5 with African American salon clients. Theory-guided focus group questions were used to explore participants’ beliefs, interests, and preferences associated with the proposed intervention. Results indicated that, across all subgroups, participants were highly supportive of the idea of a salon-based intervention to promote colonoscopy screening among African American women, citing reasons such as the commonplace nature of health discussions in salons and the belief that, with proper training, stylists could effectively deliver colorectal cancer-related health information to their clients. The greatest differences between salon staff and clients were found with respect to the specifics of the intervention. Staff focused more heavily on content-related issues, such as the specific information that should be stressed in the intervention, whereas clients focused largely on process-related issues, such as the preferred intervention formats and how stylists should present themselves to clients. The findings from this study offer both encouragement and important groundwork for the development of a salon-based, stylist-delivered intervention to promote colonoscopy screening among African American women.
Involving Nonresident Lithuanian Fathers in Child-rearing
Authors: Maslauskaitė Aušra , Tereškinas Artūras
Published: September 2017

Using nationally representative data on nonresident fathers, this study examines father–child contact and child support payments in Lithuania. We focus on previously married and cohabiting fathers whose parenting rights and obligations are organized differently by Lithuanian legislation. Our findings demonstrate that previously cohabiting fathers’ involvement in child-rearing is more significantly associated with levels of individual income resources rather than family formation type. We argue that legal uncertainties linked to nonmarital fatherhood reinforce the inequalities of men’s paternal rights and place previously cohabiting fathers, particularly with low socioeconomic resources, in disadvantaged positions. Moreover, we argue based on international evidence that universal social policies to support fathers’ social citizenship rights before separation and across household or family types, including greater individualization of Lithuania’s generous parental leave provisions, would encourage father–child contact for low socioeconomic fathers following cohabitation dissolution and reduce traditional male-breadwinning barriers to father–child contact.
Pyrexia in cats: Retrospective analysis of signalment, clinical investigations, diagnosis and influence of prior treatment in 106 referred cases
Authors: Spencer Sarah E , Knowles Toby , Ramsey Ian K , Tasker Séverine
Published: September 2017

Objectives:

The main aim of the study was to describe the features and diagnoses of a population of cats referred with pyrexia. Other aims were to report and evaluate the utility of clinical investigations performed, and describe any effect of treatment before referral on temperature at presentation and ability to make a diagnosis.

Methods:

Clinical records of cats with pyrexia (⩾39.2°C) documented at least twice were retrospectively reviewed. Cases were assigned to disease categories (infectious, inflammatory, immune-mediated, neoplastic, miscellaneous and no diagnosis [pyrexia of unknown origin, PUO]) based on diagnosis. The overall value of clinical investigations was assessed by classifying them as ‘enabling’, ‘assisting’ or ‘no assistance’ in achieving each diagnosis. The effect of treatment before referral was assessed for any association with temperature at presentation and ability to make a diagnosis (PUO vs other disease categories).

Results:

One hundred and six cases were identified. The most common cause of pyrexia was feline infectious peritonitis (22 cats, 20.8%) and the largest disease category was infectious (41/106, 38.7%). Inflammatory conditions were found in 19 (17.9%) cats, neoplasia in 13 (12.3%), miscellaneous causes in 11 (10.4%) and immune-mediated disease in six (5.7%). No diagnosis was reached in 16 (15.0%) cats, often despite extensive diagnostic investigations. Cytology and histopathology most often ‘enabled’ or ‘assisted’ in obtaining a diagnosis. Most cats (91, 85.8%) received treatment before referral, with antimicrobial treatment given to 87 (82.1%). Prior treatment before referral was not associated with temperature at presentation nor with success in establishing a diagnosis.

Conclusions and relevance:

This is the first study investigating causes of pyrexia in cats. Infectious diseases were most common and immune-mediated diseases were comparatively rare.
Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation
Authors: Silkoff Philip E , Singh Dave , FitzGerald J Mark , Eich Andreas , Ludwig-Sengpiel Andrea , Chupp Geoffrey C , Backer Vibeke , Porsbjerg Celeste , Girodet Pierre-Olivier , Dransfield Mark T , Baribaud Frederic , Susulic Vedrana S , Loza Matthew J
Published: September 2017

Rationale:

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of pathophysiologic phenotypes.

Objectives:

The purpose of the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study was to correlate clinical features and biomarkers with molecular characteristics in a well-profiled COPD cohort.

Methods:

A total of 67 COPD subjects (forced expiratory volume in the first second of expiration [FEV1]: 45%-80% predicted) and 63 healthy smoking and nonsmoking controls underwent multiple assessments including patient questionnaires, lung function, and clinical biomarkers including fractional exhaled nitric oxide (FENO), induced sputum, and blood.

Measurements and main results:

The impact of inhaled corticosteroids (ICSs), and to a lesser extent current smoking, was more associated with symptom control, exacerbation rates, and clinical biomarkers, than severity by FEV1. The ICS-treated smoking subjects were most symptomatic, with significantly elevated scores on patient-reported outcomes and more annual exacerbations ( P < .05). Inhaled corticosteroid users had greater airflow obstruction and air trapping compared with non-ICS users, regardless of smoking status. Smoking, regardless of ICS use, was associated with significantly lower FENO ( P < .05). Smoking, in non-ICS users, was associated with an elevated proportion of sputum neutrophils and reduced sputum macrophages. Increased serum C-reactive protein was observed in smokers but not in ICS and nonsmoking ICS users ( P < .05). In contrast, only air trapping and neutrophilic inflammation increased with severity, defined by postbronchodilator FEV1.

Conclusions:

Compared with COPD severity by FEV1, ICS use and current smoking were better determinants of clinical characteristics and biomarkers. Use of the ADEPT COPD data promises to prove useful in defining biological phenotypes to facilitate personalized therapeutic approaches.
Sore losers? The costs of intra-party democracy
Authors: Cross William , Pruysers Scott
Published: September 2017

Drawing upon the ‘satisfaction with democracy’ and ‘divisive primary’ literatures, this article examines how losers of intra-party elections respond to defeat and the consequences that these choices have on party organization and strength. In other words, do losers of intra-party elections continue to support the party or do they, like losers of general elections, feel less satisfied with democracy and withdraw their support (or even ‘exit’ the party)? Exploring rates of membership activism and satisfaction from a recent study of Canadian party members, this article demonstrates that losers of intra-party elections are more likely to exit the party, significantly less likely to remain active and engaged in party politics, and significantly more likely to report dissatisfaction with party membership. These findings suggest that parties must find a way of keeping losers engaged with the party.
What counts as expertise? The case of glyphosate and Jasanoff’s ‘three-body problem’
Authors: Smyth Caer
Published: September 2017

In 2015, the International Agency for Research on Cancer of the World Health Organisation published a monograph stating that glyphosate, the active ingredient in Roundup, Monsanto’s leading herbicide, was ‘probably carcinogenic to humans’. Shortly after this, the European Food Safety Authority re-assessed glyphosate’s licence for use in the European Union, and deemed it to be safe for human use. Both of these expert advisory bodies faced condemnation and accusations of political bias as a result of these assessments. Employing Jasanoff’s ‘three-body problem’, this article examines the conflicting conclusions of the International Agency for Research on Cancer and the European Food Safety Authority, exploring what the contested assessments of glyphosate reveal about the entangled relationship between scientific expertise and law-making.
Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT
Authors: Huber Jennifer S. , Hernandez Andrew M. , Janabi Mustafa , O’Neil James P. , Brennan Kathleen M. , Murphy Stephanie T. , Seo Youngho , Gullberg Grant T.
Published: September 2017

Using longitudinal micro positron emission tomography (microPET)/computed tomography (CT) studies, we quantified changes in myocardial metabolism and perfusion in spontaneously hypertensive rats (SHRs), a model of left ventricular hypertrophy (LVH). Fatty acid and glucose metabolism were quantified in the hearts of SHRs and Wistar-Kyoto (WKY) normotensive rats using long-chain fatty acid analog 18F-fluoro-6-thia heptadecanoic acid (18F-FTHA) and glucose analog 18F-fluorodeoxyglucose (18F-FDG) under normal or fasting conditions. We also used 18F-fluorodihydrorotenol (18F-FDHROL) to investigate perfusion in their hearts without fasting. Rats were imaged at 4 or 5 times over their life cycle. Compartment modeling was used to estimate the rate constants for the radiotracers. Blood samples were obtained and analyzed for glucose and free fatty acid concentrations. SHRs demonstrated no significant difference in 18F-FDHROL wash-in rate constant ( P = .1) and distribution volume ( P = .1), significantly higher 18F-FDG myocardial influx rate constant ( P = 4×10−8), and significantly lower 18F-FTHA myocardial influx rate constant ( P = .007) than WKYs during the 2009-2010 study without fasting. SHRs demonstrated a significantly higher 18F-FDHROL wash-in rate constant ( P = 5×10−6) and distribution volume ( P = 3×10−8), significantly higher 18F-FDG myocardial influx rate constant ( P = 3×10−8), and a higher trend of 18F-FTHA myocardial influx rate constant (not significant, P = .1) than WKYs during the 2011–2012 study with fasting. Changes in glucose plasma concentrations were generally negatively correlated with corresponding radiotracer influx rate constant changes. The study indicates a switch from preferred fatty acid metabolism to increased glucose metabolism with hypertrophy. Increased perfusion during the 2011-2012 study may be indicative of increased aerobic metabolism in the SHR model of LVH.
The Use of Psychosocial Services Post Hand and Upper Limb Injury and Trauma: A Pilot Study
Authors: Chown Gregory , Beckwold Mary , Chernosky Heather , Lozoskie Jonathan , Yerkes Allison
Published: September 2017

Background: Research demonstrates that hand injuries may cause psychological difficulties. To enhance recovery, therapists must provide appropriate referrals. The purpose of this study was to explore the use of psychosocial services by occupational therapists (OTs) and certified hand therapists (CHTs) post hand and upper limb injury or trauma. Methods: A quantitative survey design was implemented using a self-made questionnaire, which consisted of questions regarding demographic information, types and frequency of hand and upper limb injuries, psychiatric diagnoses, frequency of psychosocial service referrals, frames of references used, types of psychosocial assessments and interventions employed, and barriers to psychosocial services. The questionnaire was randomly distributed to 29 therapists. Results: The most frequently recorded frame of reference was the Biomechanical. Only 17.2% participants implemented psychosocial assessments. Sixteen of the 29 participants referred to 9 possible psychosocial services; however, majority of referrals were “occasionally.” OTs specialized in mental health, behavioral specialists, and social workers were recorded with the least amount of referrals. A Spearman rank correlation found a weak, but significant inverse relationship between referrals by therapists and years of experience as an OT or CHT (−0.322 and −0.351, P < .05, respectively). Conclusions: Therapists appear to be biomechanically oriented which may impact outcomes. An inverse correlation was found where the less experience participants had, the more likely they were to refer to psychosocial services. The results emphasized the lack of psychosocial assessments, interventions, and referral services being used by therapists. Further education to therapists, third parties, and other health professionals is warranted.
The Relative Contribution to Small Finger Abduction of the Ulnar Versus Radial Slip of the EDM: Implications for Tendon Transfers
Authors: Akinleye Sheriff D. , Culbertson Maya Deza , Cappelleti Giacomo , Garofolo Garret , Choueka Jack
Published: September 2017

Background: The extensor digiti minimi (EDM) tendon is commonly divided into a radial slip (EDM-R) and an ulnar slip (EDM-U). To our knowledge, the degree to which each EDM slip concomitantly abducts the small finger with active extension has not been formally tested. This study sought to characterize the comparative contributions of finger abduction inherent to each slip of the EDM to observe the sequelae of active small finger extension following transfer of the contralateral slip. Methods: Eighteen fresh-frozen cadaveric hands were used in this study. Starting with the hand in resting position, a controlled traction of 10 N was applied to each slip of the EDM tendon. The range of small finger abduction with respect to the fixed ring finger was recorded utilizing infrared reflective markers tracked through the range of motion using a digital video camera. Results: The mean abduction of the small finger when the radial slip of the EDM tendon was tested was 13.33° (95% confidence interval [CI]: 10.10°-16.55°), which was significantly different ( P ≤ .001) than small finger abduction produced by the ulnar slip of the EDM, with a mean of 23.72° (95% CI: 19.40°-28.04°). Conclusions: Given the fact that the ulnar slip of the EDM tendon is shown to be the major contributor of aberrant abduction with active small finger extension, as traction on this slip produces almost twice as much abduction as the radial slip, the EDM-U is the ideal donor graft with respect to tendon transfers of the EDM.
Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain
Authors: Yuill Matthew B , Hale David E , Guindon Josée , Morgan Daniel J
Published: September 2017

The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is expressed at high levels in the central nervous system, whereas cannabinoid 2 receptor is found predominantly, although not exclusively, outside the central nervous system. The objective of this study was to investigate potential interactions between cannabinoid 2 receptor and the mu-opioid receptor in pathological pain. The low level of adverse side effects and lack of tolerance for cannabinoid 2 receptor agonists are attractive pharmacotherapeutic traits. This study assessed the anti-nociceptive effects of a selective cannabinoid 2 receptor agonist (JWH-133) in pathological pain using mice subjected to inflammatory pain using the formalin test. Furthermore, we examined several ways in which JWH-133 may interact with morphine. JWH-133 produces dose-dependent anti-nociception during both the acute and inflammatory phases of the formalin test. This was observed in both male and female mice. However, a maximally efficacious dose of JWH-133 (1 mg/kg) was not associated with somatic withdrawal symptoms, motor impairment, or hypothermia. After eleven once-daily injections of 1 mg/JWH-133, no tolerance was observed in the formalin test. Cross-tolerance for the anti-nociceptive effects of JWH-133 and morphine were assessed to gain insight into physiologically relevant cannabinoid 2 receptor and mu-opioid receptor interaction. Mice made tolerant to the effects of morphine exhibited a lower JWH-133 response in both phases of the formalin test compared to vehicle-treated morphine-naïve animals. However, repeated daily JWH-133 administration did not cause cross-tolerance for morphine, suggesting opioid and cannabinoid 2 receptor cross-tolerance is unidirectional. However, preliminary data suggest co-administration of JWH-133 with morphine modestly attenuates morphine tolerance. Isobolographic analysis revealed that co-administration of JWH-133 and morphine has an additive effect on anti-nociception in the formalin test. Overall these findings show that cannabinoid 2 receptor may functionally interact with mu-opioid receptor to modulate anti-nociception in the formalin test.
A Medial Malleolar “Fleck Sign” May Predict Ankle Instability in Ligamentous Supination External Rotation Ankle Fractures
Authors: Nwosu Kenneth , Schneiderman Brian Andrew , Shymon Stephen Joseph , Harris Thomas
Published: September 2017

Background. Ankle joint stability dictates treatment in ligamentous supination external rotation ankle injuries (LSERAI). Investigation of the medial structures that support the ankle mortise is critical, and a small avulsion fracture, or “fleck”, of the medial malleolus is occasionally encountered. This study aimed to assess the utility of this medial malleolus fleck sign (MMFS) in diagnosing instability requiring surgery in LSERAI. Methods. This retrospective observational study examined 166 LSERAI at a single level I trauma center. A standardized diagnostic and treatment protocol for ankle fractures was followed. LSERAI at presentation were reported as having a normal, dynamically wide, or statically wide medial clear space. Patient demographics, MMFS characteristics, and the use of operative management were recorded. Results. MMFS incidence in the cohort was 16 (10%) of 166 and was present in 25% of patients with unstable LSERAI. Fifteen (94%) of 16 patients with a MMFS were deemed to have an unstable LSERAI (P < .005). MMFS had a 25% sensitivity and 99% specificity in diagnosing an unstable LSERAI. For the subgroup of patients without a statically wide medial clear space, MMFS had a 50% sensitivity and 99% specificity in determining instability. Conclusion. A MMFS may be indicative of an unstable LSERAI. With previous MRI studies demonstrating complete deltoid disruption in unstable LSERAI, we deduce the MMFS may be associated with extensive deltoid incompetence. The MMFS may help to diagnose a complete deltoid injury in LSERAI with a normal medial clear space, which could influence treatment and reduce patient morbidity, radiation exposure, and healthcare costs.

Levels of Evidence: Level III: Retrospective Cohort Study
Consumer Response to Authentic-Language Versus English-Language Menu Labeling in Ethnic Dining
Authors: Choi Sungwoo , Liu Stephanie Q. , Mattila Anna S.
Published: September 2017

Many ethnic restaurants use authentic-language labels (e.g., “Khao Pad Sapparod”), as opposed to English-language labels (e.g., “Pineapple Fried Rice”), in the menu to make their dishes appeal more authentic. Yet, the effectiveness of authentic-language labels is not well understood. To address this gap, the present research examines consumers’ attitudes toward a menu as a function of (a) authentic-language versus English-language menu labeling and (b) the consumer’s Need for Cognitive Closure (NFCC)—a fundamental desire to achieve resolution on a decision. The results show that while consumers with low NFCC prefer a menu using authentic-language (vs. English-language) labeling, their high NFCC counterparts respond more favorably to a menu using English-language (vs. authentic-language) labeling. Moreover, a moderated mediation analysis reveals that an intensified bothersome feeling in achieving resolution is the psychological mechanism explaining why authentic-language labels backfire among consumers with high NFCC. Theoretical and managerial implications are discussed.
Less than Expected? How Media Cover Demonstration Turnout
Authors: Wouters Ruud , Van Camp Kirsten
Published: September 2017

Demonstration turnout is a crucial political resource for social movements. In this article, we investigate how mass media cover demonstration size. We develop a typology of turnout coverage and scrutinize the factors that drive turnout coverage. In addition, we test whether media coverage underestimates, reflects, or exaggerates “guesstimates” by organizers and police forces. Together, these analyses shed light on whether turnout coverage fits a logic of normalization or marginalization. We rely on a unique dataset of 428 demonstrations organized in Brussels (2003–2010). For these demonstrations, we have information on the turnout as reported in national television news, as counted by the police, and as expected by the organizers. We find that media present turnout most often as a fact, rarely as contentious (10 percent). Although few demonstrations pass the media gates, our study yields little to no evidence for a logic of turnout marginalization. Media coverage does not systematically underestimate demonstration size, nor does it blindly follow police counts. Rather, turnout coverage attests of a logic of normalization, following standard news-making practices. The more important the demonstration (size, lead item) and the larger the gap between police and organizer guesstimates, the more attention is paid to turnout in the news. Discussion centers on the generalizability and normative interpretation of the results.