bluuebunny/crossref_metadata_2025 huggingface dataset:
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
Authors: Liang Zhenwen , Chen Yu , Gu Rifang , Guo Qi , Nie Xuqiang
Published: October 2022

Background:

Asiaticoside (AC) is a triterpenoid saponin found in Centella asiatica (L.) urban extract that has a wide range of pharmacological properties. Our previous study demonstrated that AC could promote angiogenesis in diabetic wounds, but the specific mechanisms remain unknown.

Objective:

This study aimed to examine the effectiveness and mechanism of AC on human umbilical vein endothelial cells (HUVECs) exposed to tert-butyl hydroperoxide (t-BHP) toxicity.

Methods:

Senescence was confirmed using senescence-associated betagalactosidase (SA-β-gal) activity and expression of the cell cycle phase markers p16 and p21. The levels of SOD, NO, MDA, GSH-Px, and ROS were tested. Furthermore, several cell death-related genes and proteins (p53, Bax, Bcl-2 and Caspase-3) were assessed with RT-qPCR and Western blotting.

Results:

AC significantly reduced SA-β-gal activity, with both the suppression of cellcycle inhibitors p16 and p21. We also found that the induced oxidative stress and apoptosis caused by t-BHP treatment resulted in the decrease of antioxidant enzymes activities, the surge of ROS and MDA, the up-regulation of p53, Bax and caspase-3, and the decrease of SOD, NO, GSH-Px and Bcl-2. These biochemical changes were all reversed by treatment with varying doses of AC.

Conclusion:

AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.
Neuroprotective Role of MiRNA-9 in Neurological Diseases:
A Mini Review
Authors: Wang Shenglin , Jiang Guohui , Wang Shunxian
Published: October 2022

MicroRNAs (miRNAs) are a class of non-coding small RNAs with about 22
nucleotides in eukaryotes. They regulate gene expression at the post-transcriptional
level and play a key role in physiological and pathological processes. As one of the
most abundant miRNAs in the human brain, miRNA-9 (miR-9) has attracted extensive
attention due to its important role in the maintenance of normal function of the nervous
system and the occurrence and development of nervous system diseases. Hence, we
reviewed the neuroprotective effect of miR-9 in neurological diseases. MiR-9 may be a
potential target of nervous system diseases.
The Role of Serum Secretoneurin Levels in Patients with Traumatic Brain
Injury
Authors: Güzel Murat , Akyüz Muhammet Faruk , Yücel Murat , Güngör İremgül , Yadigaroğlu Metin , Görgün Selim , Karataş Hüseyin
Published: October 2022

Background:

Secretoneurin is a neuropeptide expressed from endocrine, neuroendocrine,
and neural tissues. Our study aimed to investigate whether there was a relationship between secretoneurin
levels and the severity of traumatic brain injury (TBI).

Methods:

Ninety patients aged over 18 years who were admitted to the emergency department with
head trauma between April 2020 and October 2020 and 20 healthy volunteers (control group) were
included in the study. Patients were divided into three groups according to Glasgow Coma Scale
scores: Mild TBI (n=33), moderate TBI (n=28), and severe TBI (n=29). The final status of the patients
was evaluated in three groups: exitus, discharge with Glasgow Outcome Scale (GOS) ≤ 3 and
discharge with GOS >3.

Results:

The median secretoneurin levels of patients with severe TBI 31.71 (14.21-70.95) were
found to be significantly higher than in those with moderate TBI [17.30 (10.71-69.27) (P=0.025),
and patients with moderate TBI had a substantially higher level of secretoneurin than those with
mild TBI 11.70 (6-16.25) (P<0.001). There was no statistically significant difference between the
median secretoneurin levels in patients with mild TBI and the control group 10.73 (5.33-13.18)
(P=0.999). The secretoneurin cut-off value of >18.13 ng/mL had a sensitivity of 83.87% and a specificity
of 77.97% for poor neurologic outcomes (AUC 0.86, 95% CI: 0.77- 0.92). The secretoneurin
cut-off value of >20.67 ng/mL had a sensitivity of 90.91% and a specificity of 74.68% for mortality
(AUC 0.85, 95% CI: 0.76-0.92).

Conclusion:

Secretoneurin can be a useful biomarker in diagnosing patients with moderate-tosevere
TBI. It may also guide physicians in predicting the clinical outcome of patients with TBI.
Synthesis Characterization and Biological Activity of 4-Methyl-benzene
Sulfonohydrazide Derivatives
Authors: Verma Preeti , Kumar Sushil , Ojha Smriti , Mishra Sudhanshu
Published: October 2022

Background:

A schiff base is generally a bi- or tri-dentate ligand capable of forming stable
complexes with transition metals. Schiff base complexes have synthetic flexibilities and biological activity
against various diseases.

Objective:

In the current study, Schiff bases compounds (PV1 - PV5) were synthesized from 4-methyl-1-
benzene sulfonyl chloride. Subsequently, the synthesized products were analyzed for their antibacterial
activity.

Methods:

Schiff base is a nitrogen analog with a carbonyl group. The reaction that results in the formation
of new complexes involves the condensation of carbonyl compounds with an amine group. Furthermore,
thin layer chromatography, FT-IR spectroscopy, and 1H-NMR were performed for product
characterization.

Results:

All five complexes were successfully synthesized and some of the compounds demonstrated
antibacterial, antifungal, anti-inflammatory and analgesic properties.

Conclusion:

The results confirmed the structure and presence of functional groups as per the scheme of
synthesis. These synthesized compounds have the potential to treat the studied diseases and could be used
as therapeutic candidates if further research is done.
Nanotechnology: A Potential Approach for Nutraceuticals
Authors: Rene Christena Lowrence , Francis Steffi Pulikodan , Francis Mishel Pulikodan , Abdul Mohamed Haroon Basha
Published: October 2022

Nutraceuticals in the food sector open doors to the future of “nanoscience” technology
that has gained much importance. Nanotechnology has established a new perspective by providing
nanomaterials with changed features using nano-formulations and nutritional supplements in
the food sector. Nanomaterials show distinctive features owing to their tiny size and high surface/
volume ratio; thus, they are fully utilized as nutraceuticals in the food sector. The present
review article provides an exhaustive overview of the application of nanomaterials for developing
advanced nanoparticles with increased bioavailability, solubility, improved encapsulation effectiveness,
increased stability, sustained and targeted drug supply, degradation prevention, antimicrobials,
and improved pharmacological activity. It also underlines the relevance of peptides
and enzymes for food packaging and the future use of nanosensors/nano-bio sensors.
Improvised Protocol for Enhancement of Security in Internet of Vehicles
Authors: Kumar Pranjul , Kaur Sanmukh , Mehrotra Deepti
Published: October 2022

Background:

Vehicular Ad-Hoc Network (VANET) is integral to lessen road mishappenings
and to effortlessly control huge traffic on highways. Numerous protocols are researched
and implemented for creating a secure medium between vehicular nodes.

Objective:

One of the visible problems is the loss of data between the nodes, which leads to delay,
collision, and accidents in the VANET. This paper investigates traffic security and safety problems
faced in VANET and provides a solution for them.

Methods:

For analyses of traffic safety issues, 3 types of Medium Access Control (MAC) protocols
were compared, namely Conventional, Contention-Based and Contention-Free MAC Protocols. Plentiful
of performance metrics have been studied under the transportation security issues, including signal
received with error, throughput, and MAC Overhead and Packet loss.

Results and Conclusion:

By comparing the MAC Protocols, it can be concluded that Contention-Free
multi-channel SD-TDMA is better with a security mechanism for continuous and safe communication
between the vehicular nodes. It can be utilized in moderate to heavy traffic scenarios to have faster
and safe communication.
Effect and Mechanism of Curcumin on Bone Loss and Osteoporosis: A Systematic Review
Authors: Ghahfarrokhi Shahrzad Habibi , Heidari-Soureshjani Saeid , Talebi-Boroujeni Parham , Sherwin Catherine M.T.
Published: October 2022

Background:

Curcumin has been used in various diseases due to its potent anti-oxidant and anti-inflammatory properties.

Objective:

This systematic review aims to investigate the effect and mechanism of curcumin on bone loss and osteoporosis.

Methods:

Those human cell line and clinical trial studies indexed in three databases, including PubMed, Institute for Scientific Information (ISI), and Scopus, were included in the review. Records with non-English language articles, full texts not retrieved, and studies that were not relevant to the purpose of our study were excluded. Finally, after evaluating all available records, 11 articles were included.

Results:

Curcumin induces antiosteoporotic properties by inhibiting the overproduction of reactive oxygen species (ROS) and free radical scavenging activity. Curcumin, through blocking nuclear factor kappa B (NF-κB) transmission to the nucleus, can suppress the production pathways of inflammatory cytokine production. Moreover, the biological mechanism of curcumin is a complex process associated with the modulation of transcription factors, protein kinases, and antiapoptotic proteins.

Conclusion:

The results of most clinical trials and human cell-based studies support the desirable impact of curcumin on bone loss and osteoporosis. Further clinical studies are needed to derive more reliable results about the prophylactic and therapeutic properties of curcumin on osteoporosis.
KERAGAAN 13 GALUR JAGUNG UNGU (Zea mays L. var amylacea) PADA GENERASI S2
Authors: Salsabil Fatya Khalisa , Sugiharto Arifin Noor
Published: October 2022

Jagung ungu memiliki keunggulan yaitu terdapat kandungan antosianin yang bersifat sebagai antioksidan didalam tubuh. Penggunaan varietas jagung ungu hibrida dapat dilakukan untuk meningkatkan produksi jagung ungu. Keragaan tanaman merupakan sumber informasi fenotip dan genetik suatu galur. Informasi penampilan atau keragaan digunakan untuk memilih tetua yang dapat menghasilkan suatu galur dengan sifat superior. Penelitian ini bertujuan untuk mengetahui karakter kuantitatif dan kualitatif, nilai duga heritabilitas serta koefisien keragaman genetik pada galur jagung ungu yang diuji, keseragaman dalam galur serta galur yang berpotensi sebagai calon tetua hibrida. Penelitian dilaksanakan di Dusun Areng-areng, Kelurahan Dadaprejo, Kecamatan Junrejo, Kota Batu. Penelitian dilaksanakan pada bulan September 2021 sampai dengan Desember 2021. Penelitian dilakukan dengan RAK sebanyak 3 ulangan dengan menggunakan 13 galur jagung ungu masing-masing 13 tanaman. Data pengamatan terdiri dari karakter kuantitatif dan karakter kualitatif. Karakter kuantitatif dibagi menjadi dua yaitu karakter hasil dan karakter tongkol. Hasil penelitian menunjukkan karakter kuantitatif yang diamati berbeda nyata pada semua galur. Nilai duga heritabilitas dalam 13 galur jagung ungu yang diuji tergolong dalam kategori yang sedang hingga tinggi. Nilai KKG pada semua galur yang diuji dan karakter yang diamati termasuk kedalam kategori yang rendah. Sedangkan nilai KKF dari semua galur yang diuji dan karakter yang diamati berkisar antara 0.3 - 26.2%. Galur yang direkomendasikan sebagai calon yang berpotensi tetua hibrida adalah TM11 dan JM2 yang memiliki sifat seragam pada karakter intensitas antosianin pada janggel, warna permukaan biji dan jumlah susunan baris dalam keragaan jagung ungu.
Pengaruh Pinching dan Jumlah Bibit Terhadap Pertumbuhan dan Pembungaan Tanaman Krisan Pot Tipe Spray (Chrysanthemum morifolium)
Authors: Nabilah Roona Roosyidah , Nurlaelih Euis Elih , Sitawati Sitawati
Published: October 2022

Tanaman krisan (Chrysanthemum) merupakan tanaman hias potong atau tanaman hias pot. Permintaan tanaman krisan pot cukup banyak. Semakin banyak permintaan maka produksi juga akan semakin meningkat. Permasalahan yang terjadi yaitu ketersediaan bibit terbatas. Untuk mengatasi hal tersebut dapat dilakukan pinching. Penelitian ini bertujuan untuk mengetahui perlakuan pinching dan jumlah bibit yang paling sesuai terhadap pertumbuhan dan pembungaan krisan pot tipe spray yang memenuhi standar. Penelitian ini dilaksanakan pada Bulan April – Juli 2021 di greenhouse Atha Flora yang berlokasi di Dusun Gondang Legi, Daungsengon, Tutur, Pasuruan, Jawa Timur yang berada pada ketinggian 900 mdpl dan memiliki suhu rata-rata harian 24ºC. Penelitian menggunakan Rancangan Acak Kelompok (RAK) dengan 3 ulangan dan terdiri dari 9 perlakuan yaitu: (P1N1) tanpa pinching 4 bibit per pot, (P1N2) tanpa pinching dengan 3 bibit per pot, (P1N3) tanpa pinching 2 bibit per pot, (P2N1) single pinching 4 bibit per pot, (P2N3) single pinching 2 bibit per pot, (P2N2) single pinching 3 bibit per pot, (P3N1) double pinching 4 bibit perpot, (P3N2) double pinching 3 bibit per pot, (P3N3) double pinching 2 bibit per pot. Hasil menunjukkan perlakuan pinching dan pengurangan jumlah bibit per pot dapat meningkatkan jumlah daun, luas daun, jumlah cabang, dan menambah umur vase life. Akan tetapi menurunkan diameter bunga, memperpanjang waktu muncul bunga dan coloring. Perlakuan double pinching dengan penggunaan bibit 2 per pot mampu menghemat penggunaan bibit hingga 50 % dengan kualitas yang sama dengan 4 bibit per pot.
Interaksi Genotipe x Lingkungan 31 Genotipe Jagung Hibrida (Zea mays L.) di Lokasi Blitar dan Situbondo, Jawa Timur
Authors: Rahayu Ika , Soetopo Lita
Published: October 2022

Pertumbuhan dan potensi hasil suatu tanaman dipengaruhi oleh adanya interaksi genotipe dan lingkungan. Penelitian ini memiliki tujuan untuk mengetahui interaksi genotipe dan lingkungan serta genotipe yang mampu beradaptasi di dua lokasi pada 31 genotipe jagung hibrida, Penelitian dilaksanakan pada bulan Januari–April 2020 di Desa Binangun, Kecamatan Binangun, Kabupaten Blitar dan di Desa Tanjungkamal, Kecamatan Mangaran, Kabupaten Situbondo Penelitian ini menggunakan rancangan Augmented Design terdiri dari 34 entri/perlakuan (18 genotipe yang diuji, 9 varietas pendamping) tanpa ulangan dan 4 varietas sebagai control (diagonal check) diulang sebanyak 3 kali. Varietas yang digunakan sebagai control ialah P13, P35, P,36, dan P37. Analisis Ragam dengan uji F, uji lanjut DMRT (Duncan Multiple Range Test) pada taraf 5% dan analisis stabilitas metode Finlay dan Wilkinson (1963). Analisis ragam gabungan menunjukan interaksi genotipe dan lingkungan tidak terjadi perbedaan nyata pada karakter pengamatan tinggi tanaman (cm), tinggi tongkol (cm), kadar air (%)
The Effect of Oxygen-containing Additives in Feedstock on the Performance of the Catalytic Cracking Process
Authors: Guseinova Elvira , Safarova Samira
Published: October 2022

In this study, we found that adding catalytic cracking feedstock, vacuum gas oil, and naphthenic acids in the amount of 0.005–0.0075% vol. increased the liquid target fractions, i.e., gasoline and light gas oil. The decrease in the yield of hydrocarbon gas at a practically constant degree of conversion of the raw material indicated a small proportion of the reactions of re-cracking of the resulting products. This also indicated the resource-saving nature of the process, allowing a larger amount of gasoline fraction and light gas oil to be obtained, as well as, reducing the amount of coke formed on the catalyst at a constant volume of processed feedstock.
An Online Dual-Task Cognitive and Motor Exercise Program for Individuals With Parkinson Disease (PD3 Move Program): Acceptability Study
Authors: Domingos Josefa , Dean John , Fernandes Júlio Belo , Godinho Catarina
Published: October 2022

Background

Dual-task training is an emerging field used for people with Parkinson disease (PD) to improve their physical and cognitive well-being, but the patients’ acceptability, safety, and adherence to such training in online settings are unknown.

Objective

This study aims to evaluate the acceptability of a dual-task cognitive and motor online training program for people with PD as a group online community program.

Methods

People with PD were invited to participate in an online program (PD3 Move) consisting of physical and vocal exercises in response to different cognitive challenges displayed as dynamic backgrounds on Zoom. The program ran twice per week for 16 weeks. Patient acceptability was assessed at 4 months by monitoring attendance rates and feedback from an exit questionnaire emailed to all participants assessing satisfaction, perceived benefit, safety, and willingness to continue and recommend to others.

Results

The online program was delivered to 15 participants (n=9, 60%, females) with a diagnosis of PD, a mean age of 69.4 (SD 9.3) years, and Hoehn and Yahr (H&Y) stages I-IV. The attendance rate was high, with participants coming to more than 13 (81%) of the sessions. Participants were very satisfied (n=8, 53%) or satisfied (n=7, 47%) with the program. Participants reported that what they most liked were the new cognitive physical challenges. The 3 main facilitators to participating were perceiving the benefits, instructor’s flexibility and engagement, and the social interaction moments with others. The 3 main difficulties were dealing with motor fluctuations (n=3, 20%), difficulties in using technology (n=2, 13%), and difficulty hearing instructions due to hearing loss (n=2, 13%). Patients had favorable perceived benefits of the program, with 14 (93%) considering it very useful for the current management of health and 1 (7%) moderately useful. No adverse events were reported, and all participants said that they were willing to continue the program and recommend it to others.

Conclusions

Our findings suggest that the online cognitive and motor program was well received, safe, and perceived to be of benefit to this group of medically stable people with PD in H&Y stages I-IV. Access to specialized care and enhancement of long-term adherence to regular exercise can be achieved with online community group programs.
Analyzing Public Conversations About Heart Disease and Heart Health on Facebook From 2016 to 2021: Retrospective Observational Study Applying Latent Dirichlet Allocation Topic Modeling
Authors: Xue Haoning , Zhang Jingwen , Sagae Kenji , Nishimine Brian , Fukuoka Yoshimi
Published: October 2022

Background

Heart disease continues to be the leading cause of death in men and women in the United States. The COVID-19 pandemic has further led to increases in various long-term cardiovascular complications.

Objective

This study analyzed public conversations related to heart disease and heart health on Facebook in terms of their thematic topics and sentiments. In addition, it provided in-depth analyses of 2 subtopics with important practical implications: heart health for women and heart health during the COVID-19 pandemic.

Methods

We collected 34,885 posts and 51,835 comments spanning from June 2016 to June 2021 that were related to heart disease and health from public Facebook pages and groups. We used latent Dirichlet allocation topic modeling to extract discussion topics illuminating the public’s interests and concerns regarding heart disease and heart health. We also used Linguistic Inquiry and Word Count (Pennebaker Conglomerates, Inc) to identify public sentiments regarding heart health.

Results

We observed an increase in discussions related to heart health on Facebook. Posts and comments increased from 3102 and 3632 in 2016 to 8550 (176% increase) and 14,617 (302% increase) in 2021, respectively. Overall, 35.37% (12,340/34,885) of the posts were created after January 2020, the start of the COVID-19 pandemic. In total, 39.21% (13,677/34,885) of the posts were by nonprofit health organizations. We identified 6 topics in the posts (heart health promotion, personal experiences, risk-reduction education, heart health promotion for women, educational information, and physicians’ live discussion sessions). We identified 6 topics in the comments (personal experiences, survivor stories, risk reduction, religion, medical questions, and appreciation of physicians and information on heart health). During the pandemic (from January 2020 to June 2021), risk reduction was a major topic in both posts and comments. Unverified information on alternative treatments and promotional content was also prevalent. Among all posts, 14.91% (5200/34,885) were specifically about heart health for women centering on local event promotion and distinctive symptoms of heart diseases for women.

Conclusions

Our results tracked the public’s ongoing discussions on heart disease and heart health on one prominent social media platform, Facebook. The public’s discussions and information sharing on heart health increased over time, especially since the start of the COVID-19 pandemic. Various levels of health organizations on Facebook actively promoted heart health information and engaged a large number of users. Facebook presents opportunities for more targeted heart health interventions that can reach and engage diverse populations.
Passive Sensing in the Prediction of Suicidal Thoughts and Behaviors: Protocol for a Systematic Review
Authors: Winkler Tanita , Büscher Rebekka , Larsen Mark Erik , Kwon Sam , Torous John , Firth Joseph , Sander Lasse B
Published: October 2022

Background

Suicide is a severe public health problem, resulting in a high number of attempts and deaths each year. Early detection of suicidal thoughts and behaviors (STBs) is key to preventing attempts. We discuss passive sensing of digital and behavioral markers to enhance the detection and prediction of STBs.

Objective

The paper presents the protocol for a systematic review that aims to summarize existing research on passive sensing of STBs and evaluate whether the STB prediction can be improved using passive sensing compared to prior prediction models.

Methods

A systematic search will be conducted in the scientific databases MEDLINE, PubMed, Embase, PsycINFO, and Web of Science. Eligible studies need to investigate any passive sensor data from smartphones or wearables to predict STBs. The predictive value of passive sensing will be the primary outcome. The practical implications and feasibility of the studies will be considered as secondary outcomes. Study quality will be assessed using the Prediction Model Risk of Bias Assessment Tool (PROBAST). If studies are sufficiently homogenous, we will conduct a meta-analysis of the predictive value of passive sensing on STBs.

Results

The review process started in July 2022 with data extraction in September 2022. Results are expected in December 2022.

Conclusions

Despite intensive research efforts, the ability to predict STBs is little better than chance. This systematic review will contribute to our understanding of the potential of passive sensing to improve STB prediction. Future research will be stimulated since gaps in the current literature will be identified and promising next steps toward clinical implementation will be outlined.

Trial Registration

OSF Registries osf-registrations-hzxua-v1; https://osf.io/hzxua

International Registered Report Identifier (IRRID)

DERR1-10.2196/42146
Patients With Cardiovascular Disease Revisiting Specialist Physicians via Remote Treatment: Interview Study of Experiences (Preprint)
Authors: Ek Charlott , Liljegren Per-Daniel , Edin-Liljegren Anette
Published: October 2022

BACKGROUND

Access to health care for an aging population with growing needs presents major challenges in northern Sweden’s sparsely populated regions. Few people, the lack of professionals, and long distances make it difficult to provide health care on equitable terms according to the Swedish legislation. Remote treatment (RT) using information and communication technology has been suggested to overcome these difficulties, and person-centered care (PCC) is a desired philosophy to improve the quality of health care. However, there is scarce knowledge about how patients experience RT meetings.

OBJECTIVE

This study aimed to describe the experiences of patients with cardiovascular disease revisiting specialist physicians via RT guided by a PCC perspective in northern Sweden’s sparsely populated regions.

METHODS

A qualitative study was conducted based on interviews with 8 patients with cardiovascular disease revisiting their physician through RT, from a digital health room to a health care center or from a health care center to a hospital. The interviews were recorded, transcribed verbatim, and analyzed using inductive content analysis. The results are discussed from a PCC perspective.

RESULTS

The analysis resulted in 6 categories: good accessibility, safety with good relationships, proximity and distance with technology, habit and quality of the technology facilitating the meeting, cherishing personal integrity, and participation in own care. These categories were interpreted as the theme, participation and relationships are important for good and close care via RT.

CONCLUSIONS

The study shows that participation and relationships are important for good and close care via RT. To improve the quality of an RT meeting, PCC can be applied but needs to be extended to the digital domain—electronic PCC, especially the communication component, as it is the most salient difference from a face-to-face meeting. Important factors that should be considered before, during, and after the RT meeting have been identified.
Mobile Health Apps for Breast Cancer: Content Analysis and Quality Assessment (Preprint)
Authors: Yang Seongwoo , Bui Cam Nhung , Park Kyounghoon
Published: October 2022

BACKGROUND

The number of mobile health apps is rapidly increasing. This means that consumers are faced with a bewildering array of choices, and finding the benefit of such apps may be challenging. The significant international burden of breast cancer (BC) and the potential of mobile health apps to improve medical and public health practices mean that such apps will likely be important because of their functionalities in daily life. As the app market has grown exponentially, several review studies have scrutinized cancer- or BC-related apps. However, those reviews concentrated on the availability of the apps and relied on user ratings to decide on app quality. To minimize subjectivity in quality assessment, quantitative methods to assess BC-related apps are required.

OBJECTIVE

The purpose of this study is to analyze the content and quality of BC-related apps to provide useful information for end users and clinicians.

METHODS

Based on a stepwise systematic approach, we analyzed apps related to BC, including those related to prevention, detection, treatment, and survivor support. We used the keywords “breast cancer” in English and Korean to identify commercially available apps in the Google Play and App Store. The apps were then independently evaluated by 2 investigators to determine their eligibility for inclusion. The content and quality of the apps were analyzed using objective frameworks and the Mobile App Rating Scale (MARS), respectively.

RESULTS

The initial search identified 1148 apps, 69 (6%) of which were included. Most BC-related apps provided information, and some recorded patient-generated health data, provided psychological support, and assisted with medication management. The Kendall coefficient of concordance between the raters was 0.91 (P<.001). The mean MARS score (range: 1-5) of the apps was 3.31 (SD 0.67; range: 1.94-4.53). Among the 5 individual dimensions, functionality had the highest mean score (4.37, SD 0.42) followed by aesthetics (3.74, SD 1.14). Apps that only provided information on BC prevention or management of its risk factors had lower MARS scores than those that recorded medical data or patient-generated health data. Apps that were developed >2 years ago, or by individuals, had significantly lower MARS scores compared to other apps (P<.001).

CONCLUSIONS

The quality of BC-related apps was generally acceptable according to the MARS, but the gaps between the highest- and lowest-rated apps were large. In addition, apps using personalized data were of higher quality than those merely giving related information, especially after treatment in the cancer care continuum. We also found that apps that had been updated within 1 year and developed by private companies had higher MARS scores. This may imply that there are criteria for end users and clinicians to help choose the right apps for better clinical outcomes.
Frequent Mobile Electronic Medical Records Users Respond More Quickly to Emergency Department Consultation Requests: Retrospective Quantitative Study (Preprint)
Authors: Jung Kwang Yul , Kim SuJin , Kim Kihyung , Lee Eun Ju , Kim Kyunga , Lee Jeanhyoung , Choi Jong Soo , Kang Mira , Chang Dong Kyung , Cha Won Chul
Published: October 2022

UNSTRUCTURED

Correction: Frequent Mobile Electronic Medical Records (EMR) Users Respond More Quickly to Emergency Department Consultation Requests

In “Frequent Mobile Electronic Medical Records (EMR) Users Respond More Quickly to Emergency Department Consultation Requests” ([JMIR Mhealth Uhealth 2020;8(2):e14487]) the authors noted one error.

[Under tilte page “Author Kwang Yul Jung, MD1 “ has been replaced by “Kwang Yul Jung, MD1,2”]

The correction will appear in the online version of the paper on the JMIR Publications website on [November 1, 2022], together with the publication of this correction notice. Because this was made after submission to PubMed, PubMed Central, and other full-text repositories, the corrected article has also been resubmitted to those repositories.
Nephrology Program Director Protected Time for Program Administration in the United States
Authors: Yuan Christina M. , Young Brian Y. , Watson Maura A. , Sussman Amy N.
Published: October 2022

Background and objectives

The Accreditation Council for Graduate Medical Education (ACGME) required that program directors receive 10–20 h/wk of protected time for program administration (including didactic teaching). In July 2022, this was reduced for all internal medicine subspecialties on the basis of program size, with 8 h/wk required for programs with fewer than seven fellows, the majority of nephrology programs.

Design, setting, participants, & measurements

We surveyed all 151 US adult nephrology program directors (ACGME Public List of Programs 2021–2022) to determine how much protected time they receive, how much they think is necessary, and the division of their professional time. The anonymous 20-question online survey was administered from March 31 to April 30, 2022. The analysis was descriptive.

Results

Response rate was 66% (99 of 151). Geographic distribution and approved fellow positions were similar to programs nationally; 59% had fewer than seven approved positions. Median protected time was 10 h/wk (interquartile range, 5–10), with 8 h/wk (interquartile range, 5–10) for those with fewer than seven positions. Program directors estimated needing 12 h/wk (interquartile range, 10–16) to effectively administer programs, including those with fewer than seven positions, a median 5 h/wk (interquartile range, 0–7) more than received. Of program directors reporting <10 h/wk for program administration, 62% provided >20 hours of direct patient care. Thirty-nine percent had no protected time for core faculty. Fellow recruitment (68%) was the most time-consuming task, and didactic teaching (80%) was the most professionally rewarding.

Conclusions

Approximately half of the nephrology programs surveyed were not in compliance with the ACGME-stipulated 10-h/wk minimum protected time for the 2021–2022 training year. Program directors estimated a median of 12 h/wk are needed to effectively manage programs.
Core self-evaluation and career growth of Chinese graduates: Career concern and curiosity as mediators
Authors: Wang Qian , Huang Mengmeng , Hong Song , Zhang Hui , Wang Qiong
Published: October 2022

We used approach/avoidance theory and self-verification theory to investigate the influence mechanism of core self-evaluation of post-1995 generation graduates on their career growth through career concern and career curiosity, and then analyzed the moderating effect of social support
in this relationship. We collected data from 526 senior college students at six universities over three time periods, which lasted 18 months. Results show there was a positive relationship between core self-evaluation and career growth. Moreover, this relationship was partially mediated by
both career concern and career curiosity, and partially moderated by social support. These results can help graduates to manage and achieve career growth, and can help career counselors to design more effective training for students in career management.
Experiências internacionais de Community Land Trusts e lições para a implementação do modelo no Brasil
Authors: Ribeiro Tarcyla Fidalgo , Litsek Felipe Cruz Akos , Avelar Clarissa Sapori , Furtado Martim Ferraz Costa
Published: October 2022

Os Community Land Trusts (CLTs) são um modelo de gestão coletiva da terra que promove a segurança da posse, assim como o fortalecimento e o desenvolvimento comunitário para populações vulnerabilizadas. Neste artigo, com base na apresentação de experiências consolidadas no Norte e Sul globais, analisam-se os aspectos organizativos e conjunturais que podem contribuir para sua implementação no Brasil. Em seguida, o cenário fundiário brasileiro é descrito, bem como a experiência pioneira em andamento na cidade do Rio de Janeiro. O modelo, ainda incipiente no Sul Global, apresenta potencial para aplicação em assentamentos informais consolidados com vistas a garantir a segurança da posse e o direito à moradia, constantemente negado e violado nesses contextos. Dadas as peculiaridades dos CLTs no Norte e Sul globais, são sugeridas algumas lições que podem ser retiradas dos casos analisados para facilitar a implementação do modelo no Brasil.
EVALUASI KETAHANAN DAN ANALISIS QUANTITATIVE TRAIT LOCI YANG TERPAUT DENGAN KETAHANAN TERHADAP PENYAKIT UTAMA PADA TANAMAN KARET
Authors: Oktavia Fetrina , Kusdiana Alchemi Putri Juliantika
Published: October 2022

Pengembangan metode seleksi ketahanan tanaman terhadap penyakit utama perlu dilakukan, salah satunya adalah seleksi dengan bantuan marka molekuler. Penelitian bertujuan mengindenfikasi evaluasi ketahanan tanaman karet terhadap penyakit utama yang menyerang tanaman karet yaitu penyakit gugur daun Corynespora, Colletotrichum, dan Oidium, serta penyakit jamur akar putih (JAP) dan identifikasi QTL yang terpaut dengan penyakit tersebut. Populasi yang digunakan adalah 201 progeni F1 hasil persilangan klon PB 260 x SP 217. Pengamatan gejala setiap penyakit dilakukan setiap tiga bulan sekali sampai TBM 2. Peta pautan genetik yang digunakan adalah peta yang dihasilkan dari penelitian sebelumnya dengan menggunakan 263 marka SSR terseleksi. Identifikasi QTL dilakukan dengan menggabungkan data pengamatan penyakit tanaman umur dua tahun dengan peta pautan genetik menggunakan program Map QTL. Pengamatan menunjukkan bahwa terdapat variasi tingkat ketahanan progeni F1 terhadap serangan setiap patogen. Ketahanan F1 terhadap penyakit gugur daun Corynespora dan Colletotrichum serta jamur akar putih menyebar secara normal dengan tingkat keparahan serangan berkisar 0-9%, 0-22,5%, dan 0-7% secara berturut-turut. Sebaliknya terhadap penyakit gugur daun Oidium, semua progeni F1 memiliki ketahanan yang tinggi dimana keparahan penyakit kurang dari 1,5%. Tiga QTL yang terpaut dengan ketahanan terhadap penyakit gugur daun Corynespora berhasil diidentifikasi pada LG 10, 14, dan 15 dengan LOD berkisar 3,1 - 5,19 dan pengaruh QTL tertinggi sebesar 17,7%. Empat QTL yang terpaut ketahanan terhadap penyakit gugur daun Colletotrichum ditemukan pada LG 1, 3, 10, dan 16 dengan LOD 3 – 4,44 serta pengaruh tertinggi terhadap ketahanan sebesar 11,2%. Pada LG 8 LOD 2,9 berhasil diidentifikasi putatif QTL yang terpaut ketahanan terhadap JAP, sedangkan QTL yang terpaut dengan ketahanan terhadap penyakit gugur daun Oidium belum berhasil diidentifikasi. QTL yang berhasil diidentifikasi dengan LOD di atas 3 diharapkan stabil dan akan dianalisis secara berkala sehingga dapat digunakan sebagai alat bantu seleksi ketahanan.
PRODUKSI KLON IRR 112 PADA SISTEM SADAP YANG BERBEDA
Authors: Aji Martini , Supijatno Supijatno , Santosa Edi
Published: October 2022

Saat ini klon-klon yang dibudidayakan umumnya memiliki potensi produksi yang tinggi. Perolehan lateks dipengaruhi oleh beberapa faktor antara lain teknis penyadapan, waktu menyadap, umur tanaman, jenis klon, kondisi lingkungan dan iklim yang diimbangi dengan teknis budidaya yang normatif. Penelitian ini bertujuan untuk mengetahui alternatif sistem sadap dengan stimulasi terhadap produksi dan karakter fisiologi klon IRR 112. Percobaan dilaksanakan pada bulan Juli 2020 hingga Juni 2021 di Kebun Percobaan dan Laboratorium Pusat Penelitian Karet, Kabupaten Banyuasin, Sumatera Selatan, Indonesia, menggunakan klon IRR 112 dengan tahun tanam 2010. Rancangan yang digunakan yaitu petak tersarang (nested design) dengan dua faktor yaitu frekuensi penyadapan dan frekuensi aplikasi stimulan dengan 3 ulangan. Pengamatan yang dilakukan meliputi hasil produksi, konsumsi kulit, kandungan sukrosa, tiol, dan fosfat anorganik, total solid content (TSC) dan persentase kering alur sadap. Hasil penelitian menunjukkan bahwa klon IRR 112 yang disadap pada frekuensi d3 dengan pemberian stimulan 12-21 kali dalam 1 tahun menghasilkan produktivitas kumulatif rata-rata mencapai 1600 kg/ha/tahun. Penyadapan dengan frekuensi d7 diikuti aplikasi stimulan 18 kali dalam 1 tahun memberikan hasil produksi per sadap lebih tinggi dibandingkan dengan perlakuan lainnya.
PERTUMBUHAN TBM, KARAKTER FISIOLOGI, DAN KETAHANAN PENYAKIT KLON-KLON KARET IRR SERI 300 DI SUMATERA SELATAN
Authors: Syafaah Afdholiatus , Ismawanto Sigit , Oktavia Fetrina
Published: October 2022

Klon-klon karet IRR Seri 300 merupakan hasil persilangan yang dilakukan oleh Balai Penelitian Sungei Putih, Pusat Penelitian Karet pada tahun 1991 dan 1992. Pada tahun 2013 mulai dilakukan pengujian lanjutan di Kebun Percobaan Sembawa, Sumatera Selatan pada 22 klon-klon IRR seri 300 terpilih yang ditanam seluas 1 Ha masing-masing klon. Parameter pengamatan meliputi pertumbuhan tanaman, resistensi klon terhadap penyakit daun yang menyerang selama masa tanaman belum menghasilkan (TBM), karakter fisiologi awal, dan produksi tahun pertama. Hasil pengamatan pertumbuhan tanaman TBM pada 22 klon IRR Seri 300, terdapat enam klon yang mempunyai matang sadap pada umur 4,5 tahun yaitu IRR 300, IRR 301, IRR 302, IRR 307, IRR 309, dan IRR 310. Pengukuran lilit batang lanjutan sebelum penyadapan serentak dilakukan, terdapat 20 klon IRR seri 300 memiliki pertumbuhan TBM yang lebih baik daripada klon pembanding BPM 24 kecuali klon IRR 311 dan IRR 314. Selain itu, sebanyak delapan klon IRR seri 300 yang mempunyai lilit batang dan tebal kulit yang lebih baik daripada klon-klon lainnya (lilit batang > 45 cm dan tebal kulit > 5 cm), yaitu IRR 301, IRR 303, IRR 306, IRR 309, IRR 310, IRR 315, IRR 316, dan IRR 323. Kedelapan klon tersebut juga mempunyai tingkat resistensi tergolong resisten-sangat resisten terhadap penyakit gugur daun Corynespora dan Colletotrichum. IRR 306 dan IRR 310 merupakan salah satu klon harapan baru yang dapat dikembangkan di wilayah Sumatera Selatan. Pengamatan lanjutan masih perlu dilakukan untuk mendapatkan data pertumbuhan dan produksi klon-klon IRR Seri 300 pada masa tanaman menghasilkan (TM).
KARATERISTIK TANAH SALIN DENGAN PEMBERIAN BOKASHI DAN KESESUAIANNYA UNTUK MEDIA TANAM
Authors: Nugroho Priyo Adi , Sakiah Sakiah , SITOMPUL Ingrid
Published: October 2022

Pengembangan usaha agribisnis perkebunan saat ini mengarah ke lahan-lahan sub optimal. Keterbatasan topsoil dalam penyiapan bibit polibeg merupakan salah satu konsekuensinya. Penggunaan tanah salin sebagai media pengisi polibeg di lahan pasang surut tidak terlepas dari permasalahan salinitas/DHL dan pH yang alkalis. Penelitian pengaruh aplikasi 3 taraf dosis bokashi limbah kelapa sawit (200, 400, 600 g) dan masa inkubasi (1, 2, 3 bulan) pada media tanam tanah salin telah dilakukan di kampus ITSI, Medan. Tujuan dari penelitian ini adalah mengetahui pengaruh kedua faktor tersebut terhadap konsentrasi N, P, Na, Cl, pH, dan DHL. Hasil penelitian menunjukkan bahwa variasi dosis bokashi secara signifikan memengaruhi perubahan konsentrasi natrium (p-value < 0,01) dan DHL (p-value < 0,05). Kandungan N dan P yang cukup tinggi pada bokashi tidak berbanding lurus dengan kandungan N dan P pada tanah dengan perlakuan bokashi. Menurunnya kinerja mikroorganisme karena kondisi lingkungan yang salin diduga menjadi penyebab melambatnya proses dekomposisi bokashi dan mineralisasi N dan P. Terdapat korelasi yang signifikan antara N dan P (r = 0,69, p-value < 0,01) yang membuktikan bahwa konsentrasi kedua hara tersebut erat kaitannya dengan performa mikroorganisme. Namun demikian, perlakuan yang diberikan dalam penelitian ini belum dapat memodifikasi kandungan hara N dan P agar sesuai untuk pembibitan karet dan kelapa sawit.
Surgical Management of Rectal Prolapse - Review Article
Authors: Abood Hashem Bark Awadh , Alghamdi Faisal Abdullah A , Alqahtani Osama Hassan , Abdrabalamir Mohammed Abdulkareem , Albahar Hassan Zuhair , Bader Ahmed Hamzah , Muidh Faris Mohammed , Farran Osama Hashim , Aboshoushah Anmar Lutfi , Bamaoudah Ahmad Faisal , Alharthy Saud Faiz , Altowairqi Ziyad Khalid A , Chabalout Maher Nedal , Farhan Ammar Anwar Ali
Published: October 2022

Rectal prolapse procidentia is an intussusception of the whole rectal wall through the anal canal, resulting in a portion of the rectum staying periodically or occasionally permanently distal to the anus. Full-thickness prolapse and partial-thickness prolapse are the two kinds of rectal prolapse. Rectal prolapse procidentia is an intussusception of the whole rectal wall through the anal canal, resulting in a portion of the rectum staying periodically or occasionally permanently distal to the anus. It is more frequent in older females. Rectal prolapse was first recorded on papyrus circa 1500 BC. Hippocrates described rectal prolapse therapy as hanging patient’s upside down from a tree, putting sodium hydroxide to the mucosa, and fixing for three days. Today, is mostly treated surgically. Perineal surgical repairs are typically well tolerated; however, they are linked with a greater incidence of recurrence. Abdominal repairs, however, have the lowest recurrence rates. The goal of therapy is to remove the prolapse, cure any related incontinence or constipation issues, and avoid de novo bowel dysfunction. When compared to laparotomy, laparoscopic rectopexy offers fewer side effects, a shorter hospital stays, faster healing, and quicker return to work. This review aims to assess recent updates on different surgical approaches for management of rectal prolapse.
COMPARATIVE LEGAL ANALYSIS OF ACTIVITIES STATE DUMA 1905-1917
Authors:   Central Russian Institute of Management, Branch of RANEPA, SHCHEGOLEVA N.A. , KLEVTSOV M.I. ,   Oryol State University named after I.S. Turgeneva
Published: October 2022

The purpose of this article is to consider the features of the development and functioning of the lower house of parliament by comparing The State Duma of the modern and pre-revolutionary models. The foundations of parliamentarianism in Russia, laid in 1905, served as the basis for a whole system of interaction between state bodies, which partly operates to this day. Despite the fact that The State Duma existed in the Russian Empire for only 12 years, it was an important step towards the establishment of a constitutional monarchy, which ultimately did not come true.
PARTY AND POLITICAL LEADERSHIP OF THE SYSTEM OF PROFESSIONAL EDUCATION OF EMPLOYEES OF THE NKVD-MINISTRY OF Internal Affairs OF THE USSR (1920-1980-ies)
Authors:   Academy EMERCOM of Russia, TSYBAKOV D.L. , GARINA O.V. ,   Orel Law Institute of the Ministry of Internal Affairs of the Russian Federation named after Lukyanov V.V.
Published: October 2022

This article aims to analyse the genesis of the practice of the party leadership of vocational training for the soviet police and State security bodies. The authors trace the process of development of the structure of secondary and higher educational institutions of All-Russian Extraordinary Commission, Joint State Political Directorate, People's Commissariat for Internal Affairs and the Ministry of State Security, as well as the Ministry of Internal Affairs of the USSR in the period from the early 1920s to the mid-1980s. It argues for the idea that the party and political control over the system of secondary and higher education is carried out by the deputies for political affairs and the Communist Party of the Soviet Union. The article analyses archive materials of the primary party organization of Orel secondary special police school of the Ministry of Internal Affairs of the USSR. In conclusions it should be noted that the recent strengthening of the party and political control over the activities of educational institutions of the Ministry of Internal Affairs is associated with increasing ideo-logical confrontation between the West and the USSR at the turn of the 1960s and 1970s.
JOURNAL «INDUSTRY AND TRADE» – THE LEADING PRINTING BODY OF RUSSIAN BUSINESS (1908–1918)
Authors:   Financial University under the Government of the Russian Federation, SHAPKIN I.N.
Published: October 2022

The main purpose of the study is to analyze the journal «Industry and Trade» as the leading mouthpiece of Russian business in the period from 1908 to 1918. It is stressed that All-Russian business organization the Congresses of representatives of Industry and Trade is created in 1906 and the magazine «Industry and Trade» is its printing body. The article is concerned with the main stages and directions of the journal's activity. It is shown that the main function of this mouthpiece is to strengthen the influence of entrepreneurship on economic processes in the country, on the development of the government economic policy, to promote the unification of members of society and strengthening of cooperation between other institutions of the emerging civil society. In conclusion, it should be noted that the lobbying practice of the new union is reflected in the pages of the publication.
THE POLICY OF THE RUSSIAN AUTHORITIES REGARDING THE WAQFS OF «HOLY PLACES» IN CENTRAL ASIA IN THE PRE-REVOLUTIONARY PERIOD
Authors:   Yelets State University named after I.A. Bunin, LITVINOV V.P.
Published: October 2022

The main purpose of the article is to consider the problem of the «holy places» waqfs in the Turkestan General Government (Territory). It is indicated that there was a large number of holy places of both local and regional significance, and places of worship, which were visited by pilgrims from territories neighbouring Central Asia. It is stressed that after coming of Russia to this region, the authorities of Turkestan made repeated attempts to bring under control the funds received from waqf property of holy places, but they did not lead to any significant results. In conclusion, it should be noted that obviously, the authorities of Turkestan were afraid to act harshly in solving this problem, realizing that this could lead to the collapse of the system that took shape over the centuries and which in fact was a reflection of patriar-chal-feudal relations in this sensitive for Russia region.