bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic variants of MUC4 are associated with prevalence and mortality of colorectal cancer and exhibit synergistic effects with LDL-C levels
Authors: Kwon Min Jung , Lee Jeong Yong , Kim Eo Jin , Ko Eun Ju , Ryu Chang Soo , Cho Hye Jung , Jun Hak Hoon , Kim Jong Woo , Kim Nam Keun
Published: September 2022

As a disease with high mortality and prevalence rates worldwide, colorectal cancer (CRC) has been thoroughly investigated. Mucins are involved in the induction of CRC and regulation of intestinal homeostasis. However, the role of MUC4, which is a member of the mucin gene family, is controversial because it shows an association with either decreased susceptibility to or a worse prognosis of CRC. In our study, the multifunctional aspects of MUC4 were elucidated by genetic polymorphism analysis in a case-control study of 420 controls and 464 CRC patients. The MUC4 rs1104760 A>G polymorphism had a protective effect on CRC risk (AG, AOR = 0.537; GG, AOR = 0.297; dominant model, AOR = 0.493; recessive model, AOR = 0.382). In addition, the MUC4 rs2688513 was associated with an increased mortality rate of CRC (5 years, GG, adjusted HR = 6.496; recessive model, adjusted HR = 5.848). Furthermore, a significant synergistic effect was observed between MUC4 rs1104760 A>G and low-density lipoprotein cholesterol (LDL-C) indicating a high potential as a biomarker for CRC susceptibility. This is the first study to indicate a significant association between MUC4 genetic polymorphisms and CRC prevalence, suggesting a functional genetic variant with the LDL-C level, for CRC prevention.
Analysis of Clinical Implications and Immune Landscape in Prognostic Model based on Immune Cell Signatures for Lung Adenocarcinoma Patients
Authors: Gao Weitong , Zhou Yang , Zong Yuxuan , Wang Nana , Nanding Abiyasi , Yu Yan
Published: September 2022

Lung cancer is the most common cancer type and major cause of death from malignancy worldwide. Immune cells such as lymphocytes infiltrated in tumor are identified as strong prognostic biomarkers for lung adenocarcinoma (LURD) patients. In our research, based on immune cell signatures infiltrated in tumor immune microenvironment, we developed and verified a risk score model by selecting six valuable prognostic genes: CD1C, CR2, MS4A1, SFTPC, STAP1 and TFF1 for risk stratification and survival prediction in LURD patients. Furthermore, the associations of risk score with tumor-infiltrating immune cells, immunotherapy-related biomarkers and immune checkpoints were also evaluated. Based on above, we made conclusions that the risk score model as a robust prognosis biomarker can screen the population who can benefit potentiallyfrom immunotherapy, thus improving diagnostic accuracy and optimizing clinical decision in LURD management.
Prediction of femoral head necrosis after Garden type I fracture with CT three-dimensional reconstruction
Authors: Zhan Hongqi , Ma Jianxiong , Cui Shuangshuang , Sun Lei , Jin Hongzhen , Wang Ying , Bai Haohao , Lu Bin , Ma Xin-Long
Published: September 2022

Background: Too large posterior tilt after Garden type I femoral neck fracture may lead to femoral head necrosis, but the measurement of posterior tilt is not accurate. Therefore, this study used computed tomography (CT) three-dimensional (3D) reconstruction to measure the relationship between posterior tilt and femoral head necrosis.
Methods:A total of 110 patients with Garden type I femoral neck fracture admitted to Tianjin Hospital from 2016 to 2020 were retrospectively analyzed. According to whether femoral head necrosis occurred after operation, they were divided into femoral head necrosis group and non-necrosis group.3D reconstruction was used to measure the posterior tilt of femoral head. The clinical data between the two groups were compared, the risk factors of femoral head necrosis were analyzed by multivariate logistic regression, and the predictive value of posterior tilt on postoperative femoral head necrosis was evaluated by the receiver operating characteristic (ROC) curve.
Results: A total of 110 patients were followed up for 18-66 months (mean, 29 months). Necrosis occurred in 12 patients (10.9 %). Multivariate logistic regression analysis showed that BMI≥25kg/m2, reduction quality grade C, and posterior tilt≥20° were risk factors for femoral head necrosis. ROC curve analysis showed that the 3D measured posterior tilt had predictive value for postoperative femoral head necrosis, and the predicted cut-off value was 19.6°.
Conclusion: For patients with Garden type I fractures, BMI≥25kg/m2, reduction quality grade C, and posterior tilt≥20° were risk factors for femoral head necrosis after closed reduction and internal fixation. The measurement of posterior tilt by CT 3D reconstruction can better predict the occurrence of femoral head necrosis in patients with Garden type I.
Breath-by-breath P0.1 measurement without airway occlusion may result in underestimation of respiratory drive
Authors: Takane Ryo , Nakajima Mikio , Miwa Maki , Kaszynski Richard H. , Nakano Tomotsugu , Goto Hideaki , Takeuchi Muneyuki
Published: September 2022

We aimed to identify the threshold for P0.1 in a breath-by-breath manner measured without airway occlusion for high respiratory drive. In this prospective observational study, we found P0.1 measured without airway occlusion, esophageal P0.1 and esophageal pressure swing had a positive correlation. However, the P0.1 threshold for high respiratory drive was calculated at approximately 1.0 cmH2O from the regression equation. Our calculations suggest a lower threshold of P0.1 measured without airway occlusion than that which has been previously reported.
Low FBXL7 Expression Indicates Low Overall Survival in Bladder Cancer
Authors: Xia Qier , Hu Xinyue , Li Jun , Shen Yifan , Wei Haibin , Qian Jing , Zhang Dahong
Published: September 2022

Background: F-box/LRR-repeat protein 7 (FBXL7) is a ubiquitin ligase associated with a poor prognosis in a variety of cancers. However, its prognostic value in bladder cancer has not been established. We evaluated the clinicopathological characteristics of FBXL7 and its predictive significance in bladder cancer (BLCA).
Methods: Gene Expression Omnibus（GEO）and The Cancer Genome Atlas (TCGA) were used for a comprehensive investigation of the mRNA expression profile of BLCA. The diagnostic value of FBXL7 in TCGA-BLCA was verified using receiver operating characteristic curves. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses as well as a gene set enrichment analysis were performed. Bladder cancer and paracancerous tissues were collected in clinic, and Immunohistochemical(IHC) verified the expression of FBXL7.
Results: Genes co-expressed with FBXL7were enriched for extracellular matrix structural components, transmembrane receptor protein kinase activity, as determined by a GO enrichment analysis. A KEGG pathway enrichment analysis revealed that the co-expressed genes were related to the cell cycle, mitogen-activated protein kinase signaling pathway. Patients with low levels of FBXL7 expression had a worse prognosis than that of patients with high expression levels, according to a Kaplan–Meier survival analysis. IHC results showed high expression of FBXL7 in paracancerous tissues and low expression in bladder cancer tissues.
Conclusion: The differentially expressed genes identified in this study clarify the molecular pathways leading to BLCA. Our results indicate that FBXL7 may improve clinical decision-making in BLCA and is an indicator of poor survival.
Bayesian optimization with constraints based on explanation-based learning and its application in materials research
Authors: Ohno Hiroshi
Published: September 2022

The present paper describes an algorithm for improving the convergence of Bayesian optimization (BO) using the constraints derived from symbolic learning and inference for observations by explanation-based learning (EBL). During the BO process, the constraints based on observations generalized by the domain knowledge (theory) of EBL are applied to maximization of the acquisition function, thereby improving the efficiency of exploration. For the maximization, a (1 + 1)-evolutionary strategy is exploited to incorporate the constraints. In addition, knowledge regarding the improvements is provided as a human-readable representation, which is reflected by the domain theory. Using synthetic and real-world data provided by experiments of lithium-ion batteries to maximize ionic conductivity, the effectiveness of the proposed algorithm is demonstrated. The obtained knowledge is reasonable in the domain theory regarding high ionic conductivity. Thus, the effect of improving explainability for the optimization is shown.
Investigating the Effects of Maltreatment and Acute Stress on the Concordance of Blood and DNA Methylation Methods of Estimating Immune Cell Proportions
Authors: Apsley Abner T. , Etzel Laura , Hastings Waylon J. , Heim Christine C. , Noll Jennie G. , O’Donnell Kieran J. , Schreier Hannah M. C. , Shenk Chad E. , Ye Qiaofeng , Shalev Idan
Published: September 2022

Background:
Immune cell proportions can be used to detect pathophysiological states and are also critical covariates in genomic analyses. The complete blood count (CBC) is the most common method of immune cell proportion estimation, but immune cell proportions can also be estimated using whole-genome DNA methylation (DNAm). Although the concordance of CBC and DNAm estimations has been validated in various adult and clinical populations, less is known about the concordance of existing estimators among stress-exposed individuals. As early life adversity and acute psychosocial stress have both been associated with unique DNAm alterations, the concordance of CBC and DNAm immune cell proportion needs to be validated in various states of stress.
Results:
We report the correlation and concordance between CBC and DNAm estimates of immune cell proportions using the Illumina EPIC DNAm array within two unique studies: Study 1, a high-risk pediatric cohort of children oversampled for exposure to maltreatment (n=365, age 8 to 14 years), and Study 2, a sample of young adults who have participated in an acute laboratory stressor with four pre- and post-stress measurements (n=28, number of observations=100). Comparing CBC and DNAm proportions across both studies, estimates of neutrophils (r=0.948, p<0.001), lymphocytes (r=0.916, p<0.001), and eosinophils (r=0.933, p<0.001) were highly correlated, while monocyte estimates were moderately correlated (r=0.766, p<0.001) and basophil estimates were weakly correlated (r=0.189, p<0.001). In Study 1, we observed significant deviations in raw values between the two approaches for some immune cell subtypes, however, the observed differences were not significantly predicted by exposure to child maltreatment. In Study 2, while significant changes in immune cell proportions were observed in response to acute psychosocial stress for both CBC and DNAm estimates, the observed changes were similar for both approaches.
Conclusions:
Although significant differences in immune cell proportion estimates between CBC and DNAm exist, as well as stress-induced changes in immune cell proportions, neither child maltreatment nor acute psychosocial stress alters the concordance of CBC and DNAm estimation methods. These results suggest that the agreement between CBC and DNAm estimators of immune cell proportions is robust to exposure to child maltreatment and acute psychosocial stress.
Robotic Repair of Non-Midline Hernias
Authors: Guo Alyssa , Isaac Dillon , Jaraczewski Liliana , Cobb William , Carbonell Alfredo , Warren Jeremy
Published: September 2022

Background
Non-midline abdominal wall hernias present unique anatomic challenges, making repair more complex. The constraints of the peritoneal cavity, pelvis, and costal margin limit the utility of intraperitoneal mesh repair, and extraperitoneal repairs have traditionally been performed using open techniques, often resulting in higher wound morbidity. Advances in minimally invasive surgery make visualization and dissection of such complex cases feasible, with all the attendant benefits of a minimally invasive over an open approach. In this study we examined the use of the robotic platform to repair non-midline hernias.
Methods
Retrospective review of all non-midline abdominal wall hernias performed robotically at Prisma Health, excluding parastomal hernias. Study conducted and outcomes reported according to STROBE statement.
Results
Repair was performed in the retromuscular space (n=42), preperitoneal (n=22), and intraperitoneal (n=1). Mean hernia width was 9.4cm, permanent synthetic mesh used for all repairs. Mean LOS was 1.5 days. Surgical site occurrence (SSO) occurred in 49.2%, 78% of which were simple seroma. Three patients (4.6%) developed surgical site infection (SSI). Two recurrences were identified with a mean follow-up of 11 mos.
Conclusion
The robotic platform facilitates complex dissection to allow minimally invasive, extraperitoneal repair of complex non-midline hernias. This approach overcomes the anatomic constraints of intraperitoneal mesh repair and the wound morbidity of open repair.
A robust fuzzy-stochastic optimization model for managing open innovation uncertainty in the ambidextrous supply chain planning problem
Authors: Rahmanzadeh Sajjad , Pishvaee Mir Saman , Rasouli Mohammad Reza
Published: September 2022

This paper studies the effect of the open innovation concept in the product design process and supply chain master planning. Complex uncertainties caused by using outbound resources within co-design processes, financial challenges between the collaborating parties, and integrating outbound innovative designs with supply chain tactical planning problem are taken into account. To this end, a robust fuzzy-stochastic optimization model is proposed which can integrate the product design with the main activities of a multi-product supply chain. The proposed model is able to cope with different type of uncertainties including random, epistemic and deep uncertainties. Integrating the financial and physical flows, using a novel pricing mechanism, and considering the outside-in innovations in the product design process are the outstanding contributions of the proposed model. Furthermore, to cover both the short-term and long-term success criteria, ambidexterity of the studied supply chain is taken into account via two conflicting explorative and exploitive objectives. Results indicate the superiority of the presented model and its ability in supporting managerial decisions in the mid-term planning process.
Models and algorithms for U-shaped assembly line balancing problem with collaborative robots
Authors: Li Zixiang , Janardhanan Mukund , Tang Qiuhua , Zhang Zikai
Published: September 2022

The collaborative robot (cobot) are increasingly being utilized in industries due to the advancement in the field of robotic technology and also due the increase in labor costs. The cobots on the assembly line can be utilized to complete the tasks independently or assist the workers to complete the tasks. This study considers the U-shaped assembly line balancing problem with cobots, where several cobots with different purchasing costs are selected under the budget constraint. Three mixed-integer programming models are formulated to optimize the cycle time and the built models are capable of solving the small-sized instances optimally. Two algorithms, artificial bee colony algorithm and migrating bird optimization algorithm are developed and improved to tackle the large-sized instances, where new encoding scheme and decoding procedure are developed for this new problem. The computational tests demonstrate that the utilization of collaborative robots reduces the cycle time effectively in the assembly line. The comparative study on a set of instances shows that the proposed methodologies obtain competing performance in comparison with other 12 implemented algorithms.
Application of BIOfid tools for extracting data from biodiversity literature
Authors: Kasperek Gerwin , Abrami Giuseppe , Driller Christine , Lücking Andy , Mehler Alexander , Martínez-Muñoz Carlos Alberto , Pachzelt Adrian
Published: September 2022

In an ideal world, extraction of machine-readable data and knowledge from natural-language biodiversity literature would be done automatically, but not so currently. The BIOfid project has developed some tools that can help with important parts of this highly demanding task, while certain parts of the workflow cannot be automated yet. BIOfid focuses on the 20th century legacy literature, a large part of which is only available in printed form. In this workshop, we will present the current state of the art in mobilisation of data from our corpus, as well as some challenges ahead of us. Together with the participants, we will exercise or explain the following tasks (some of which can be performed by the participants themselves, while other tasks currently require execution by our specialists with special equipment): Preparation of text files as an input; pre-processing with TextImager/TextAnnotator; semiautomated annotation and linking of named entities; generation of output in various formats; evaluation of the output. The workshop will also provide an outlook for further developments regarding extraction of statements from natural-language literature, with the long-term aim to produce machine-readable data from literature that can extend biodiversity databases and knowledge graphs.
Intellectual capital and industrial firms’ growth: Evidence from Jordanian manufacturing listed firms
Authors: Fawzi Shubita Mohammad
Published: September 2022

This paper deals with the link between intellectual capital and the Jordanian industrial listed companies’ growth. This relationship is meaningful for the companies to enhance their interest in intangible assets. The study employed a regression analysis; independent variables are intellectual capital and intellectual capital components (human capital, structural capital, and capital employed). The current ratio is used as a control variable. The study sample, which contains 785 observations, is divided into the firms that generate positive ROE and those that generate negative ROE. The study sample included 77 Jordanian industrial listed firms during the period 2006–2020. The paper found that intellectual capital does not have a significant effect on industrial firm growth and its components do not have a significant effect on industrial firm growth. The main conclusions drawn from these results are that the return on equity do not affect the link between intellectual capital and industrial firms’ growth. The paper recommended applying the study models to other sectors like banks and service sectors and including other control variables like leverage and company size in these models.
Prodrugs of Nucleoside 5'-Monophosphate Analogues: Overview of
the Recent Literature Concerning their Synthesis and Applications
Authors: Roy Béatrice , Navarro Valentin , Peyrottes Suzanne
Published: September 2022

Nucleoside analogues are widely used as anti-infectious and antitumoral
agents. However, their clinical use may face limitations associated with their physicochemical
properties, pharmacokinetic parameters, and/or their peculiar mechanisms of action.
Indeed, once inside the cells, nucleoside analogues require to be metabolized into
their corresponding (poly-)phosphorylated derivatives, mediated by cellular and/or viral
kinases, in order to interfere with nucleic acid biosynthesis. Within this activation process,
the first-phosphorylation step is often the limiting one and to overcome this limitation,
numerous prodrug approaches have been proposed. Herein, we will focus on recent literature
data (from 2015 and onwards) related to new prodrug strategies, the development of
original synthetic approaches and novel applications of nucleotide prodrugs (namely pronucleotides)
leading to the intracellular delivery of 5’-monophosphate nucleoside analogues.
The Correlation Between Modified Total Cerebral Small Vessel Disease
Score and Gait and Balance Disorder in Middle-aged to Older Adults
Authors: Hu Wenli , Hou Yutong , Yang Shuna , Li Yue , Qin Wei , Yang Lei
Published: September 2022

Background and purpose:

The aim of this study is to investigate the relationships between the original and modified total cerebral small vessel disease (CSVD) score and gait and balance impairment using quantitative and semi-quantitative tests.

Methods:

In our study, patients aged 45 to 85 years were recruited consecutively.
CSVD manifestations were identified with brain magnetic resonance imaging (MRI), and the original and modified CSVD scores were calculated based on the results. Gait and balance function were assessed using both gait parameters and clinical rating scales. The correlation between the original and modified total scores of the CSVD and gait and balance dysfunction was demonstrated.

Results:

224 patients were enrolled in the study. Gait and balance disorders were associated with both the original and modified CSVD scores. A significant association remained after adjusting for gender, height, age, hypertension, and other relevant risk factors. The binary logistic regression and chi-squared trend tests revealed that impairment of movement function significantly correlated with the modified CSVD score and that the dysfunction was significantly higher for patients with modified CSVD scores of 5-6 than those with scores of 1-2. In receiver operating characteristic (ROC) analysis, modified CSVD scores were more accurate in predicting gait impairment than original CSVD scores.

Conclusion:

We found both original and modified total CSVD scores to be related to gait and balance disorder, and the modified CSVD score was more accurate in identifying movement impairment and should be used as an effective tool in investigating CSVD and motor dysfunction.
In-Silico Designing of a Multi-Epitope Vaccine against SARS-CoV2 and
Studying the Interaction of the Vaccine with Alpha, Beta, Delta and Omicron
Variants of Concern
Authors: Paul Santanu , Pal Aranya , Pyne Nibedita
Published: September 2022

Background:

The sudden appearance of the SARS-CoV2 virus has almost changed the future
of vaccine development. There have been many different approaches to vaccination; among them,
computational vaccinology in the form of multi-epitope vaccines with excellent immunological properties
and minimal contamination or other adverse reactions has emerged as a promising strategy with
a lot of room for further study in this area.

Objective:

Designing a multi-epitope vaccine from the spike protein of SARS-CoV2 based on immunoinformatics
and in-silico techniques. Evaluating the binding affinity of the constructed vaccine
against the major variants of concern (alpha, beta, delta, and omicron) using docking studies.

Method:

The potential antigenic, immunogenic, and non-allergic T-cell epitopes were thoroughly explored
using IEDB, NetCTL1.2, and NetMHCII pan 3.2 servers. The best suitable linker was identified
using the ExPASy Protparam tool and VERIFY 3D. The 3D model of the vaccine was developed
by RaptorX and the model was validated using ERRAT, Z-score, and Ramachandran Plot. Docking
studies of the vaccine with TLR-2, 3, 4, and 7 and alpha, beta, delta, and omicron variants were performed
using HADDOCK 2.4.

Results:

The vaccine construct showed good antigenic and immunogenic scores and was non-allergic
as well. The model was capable of binding to all four selected Toll-like receptors. Docking scores with
variants were also promising.

Conclusion:

All the variants showed good binding ability with the vaccine construct. Interaction with
the alpha variant was found to be the most intense, followed by delta, beta, and omicron.
Mature Teratoma Revisited: A Rare Isolated Intrapulmonary Presentation:
Case Report
Authors: Ehab Ahmed , Shalabi Ahmad , Nawgiri Avinash , Reissfelder Florian , Graeter Thomas
Published: September 2022

Background:

Intrathoracic teratoma is a form of germ cell tumors and is mostly found in the anterior mediastinum. Isolated intrapulmonary teratoma (IPT) is by far a rarity. The clinical presentation is often non-specific and radiological images – in most of the cases- is not sufficient to establish a final diagnosis.
Surgical resection is the gold standard curative treatment after proper preoperative assessment.

Case presentation:

In this case report, we describe a case of an IPT in a 33 year old female patient, who presented with hemoptysis, and was successfully treated with right upper lobe resection. The diagnosis was histologically proven as a mature IPT.

Conclusion:

IPT is extremely rare. Surgical resection is the gold standard method for both diagnostic and curative purposes. Strict preoperative assessment should be performed to exclude other cases of lung masses.
Design of Wireless Motion Sensor Nodes based on the Kalman Filter
Algorithm
Authors: Zhang Yuye
Published: September 2022

Background:

In recent years, wireless sensor network technology has been the center
of attention in the international community. It has been a key element in e-health to monitor bodies.
This technology enables new applications in different domains, including medical, physical
training, etc.

Method:

Some sensors in WSN (Wireless Sensor Nodes) capture physiological data such as
temperature, heartbeat and moving distance. The ECG signal is obtained by an analog front-end
chip ADS1292 and processed by an adaptive Kalman filter algorithm. The sensor LMT70 is used
to gather the body temperature; the acceleration sensor MPU6050 is used to detect, capture, recognize
and identify other body gestures and motions data and the STM32F103C8 microprocessor
is used as the kernel control module. WSN sensor nodes provide wireless monitoring due to transceiver
module NRF24L01for anybody, anywhere and anytime.

Result:

Each measurement result can meet physiological index demands.

Conclusion:

The system can be used to avoid sports accidents and injuries and to plan for future
training and realized in LAB conveniently owing to the high cost-performance ratio.
Possibility of Liver Cancer Treatment By Nanoformulation of Phenolic
Phytochemicals
Authors: Patra Prasun , Banik Debayan
Published: September 2022

Cancer is a group of disease where the body cells continuously grow without proper cell division thereby causing tumours and leading to metastasis. Among many types of cancer, liver cancer remains a common and leading cause of human death. Plants have always been a great source of medicine and pharmacotherapy. Phytochemicals are plant-produced metabolites and phe-nolic phytochemicals are a subclass of it. Phenolic phytochemicals like curcumin, gallic acid and EGCG are secondary plant metabolites. They have been found to be effective and can improve the cell signalling pathways that govern cancer cell proliferations, inflammations, nearby invasions, and apoptosis. These phenolic phytochemicals greatly induce cell apoptosis and inhibit cancer cell growth. In this review article, we discuss how to improve the mentioned phytochemical's potency against hepatocellular carcinoma (HCC). One of the best approaches to improve the efficacy of these natural phytochemicals is to prepare nano formulations of these phytochemicals. Nano formu-lations impressively increase bioavailability, stability, absorption in the body and increased effi-ciency of these phytochemicals. The diverse character of many nanoparticles (NP) discussed in this article enables these systems to exhibit strong anticancer activity, emphasising combined therapy's benefits and necessity to combat cancer. In addition, nano formulations of these phenolic phyto-chemicals remarkably show a high apoptosis rate against HepG2 cells (HCC).
Candelilla and Rice Bran Wax as Oleogelators in Soybean Oil for Deep Frying Application
Authors:   Sime Darby Plantation Research Sdn Bhd, Badrul Zaman Maslia Manja , Ahmad Hairi Amelia Najwa ,   Sime Darby Plantation Research Sdn Bhd, Saparin Norliza ,   Sime Darby Plantation Research Sdn Bhd, Md Noor Ahmadilfitri ,   Sime Darby Plantation Research Sdn Bhd
Published: September 2022

International health association such as American Heart Association (AHA), European Food Safety Authority (EFSA) and World Health Organization (WHO) recommend limiting saturated fat (SAFA) intake in daily diet due to the health concerns that they are linked to. However, SAFA can provide frying stability and provide crispy texture to the fried food. In this study, soybean oil which is known to have low SAFA was structured using 5% natural waxes: Candelilla wax (CNW) and Rice Bran wax (RBW) via oleogelation techniques. Oleogels can be defined as a structured liquid vegetable oil entrapped within a three-dimensional, thermo-reversible gelation network. Upon preparing the oleogels, the oleogels were subjected to frying application to determine its frying performances. Results show that the addition of waxes can help to control the increment of free fatty acids, total oxidation value and total polar compounds in the oil. Addition of waxes also show reduced oil absorption in food upon frying. However, the color changes of the wax added frying oils are much faster throughout the frying process. Therefore, natural waxes such as RBW and CNW have promising potential to be used in solidifying soybean oil for frying application.
Kearifan Lokal Penataan Ruang Wilayah Mukim Yang Berkelanjutan Di Aceh
Authors: Nazaruddin T. , Sulaiman Sulaiman , Yulia Yulia
Published: September 2022

Until now there has not been an in-depth and comprehensive of spatial planning based on local wisdom as strengthening the specificity of the Aceh region based on Law Number 11 Year 2016 concerning Aceh Government and Qanun No. 4 of 2003 concerning the Mukim Government. The purpose of this study is to analyze the local wisdom of spatial planning for sustainable settlements in Aceh. This research is a normative-supported empirical law study. The results showed that in the preparation of the Rencana Tata Ruang Wilayah (RTRW) the Mukim/mukim was not involved. In fact, information regarding the RTRW documents was never shared with the Imeum Mukim. The results of research in the residential areas of Aceh Besar, Pidie Jaya and North Aceh districts found that generally Mukims submitted the same complaints where Mukim was not informed or involved in the preparation of the RTRW in their area. Mukim’s authority is only limited to the resolution of disputes arising among the residents of the village in the Mukim region.
The Domination Of Indonesian Ulama Council Withhold Law Of Halal Product Guarantee
Authors: Safa'at Muchamad Ali
Published: September 2022

In the relation of law and politic perspective, law is not a neutral entity. Law is a battleground domain for political interests and as instrument of group domination. It can be seen in the formation and implementation of the Halal Law. This research aims to analyze the role of Indonesian Ulama Council (MUI) in the formation and implementation of the Halal Product Guarantee Act. This research uses socio legal method. The research result shows that MUI dominates by hold up the formation and implementation of the Halal Law. This is done by dominating the legitimacy of identity as a religious organization and using a network of organizations and political actors so that the process of establishing rules and administering halal law by BPJPH is hampered. Delegitimacy and disturbance are also experienced through requests for judicial review of the Halal Certification Law to the Constitutional Court and lawsuits to the courts.
Dinamika Perkembangan Batas Usia Perkawinan Dalam Perspektif Hukum Progresif
Authors: Rifqi Muhammad Jazil
Published: September 2022

This article aims to explore the development of the minimum age for marriage in Indonesian legislation and analyze it with progressive law. To explain the transformation of law, this literature research uses a social history approach. This study found that the embryonic age limit for marriage had actually been seen in legal pluralism before the enactment of the 1974 Marriage Law. The marriage age in the Marriage Law Number 1 of 1974 was stated to be 16 years for women and 19 years for men. Unfortunately, the regulation was not in line with the development of society, so it was tested in the Constitutional Court. In 2017, article 7 paragraph (1) was examined where the Constitutional Court granted the request by equating the marriage age to 19 years for men and women. The House of Representatives then amended the Marriage Law as contained in Law Number 16 of 2019. This reform illustrates that the law is not final and absolute, under certain conditions as long as it provides benefits for humans, it is necessary to revise the law. Not vice versa, allowing people to enter into legal schemes that have a negative impact on health, education, economy and so on, but laws that must be studied and corrected.
Optimalisasi Peran Pengawasan Otoritas Jasa Keuangan Terhadap Baitul Maal Wa Tamwil Di Yogyakarta
Authors: Yunita Ani , Martiana Andri , Wijayanti Riska
Published: September 2022

This research aims to determine the problems faced by Financial Services Authority in carrying out the supervisory, and to optimize the role of OJK's supervision in the implementation of BMT operational activities in Yogyakarta. This is empirical normative research. The results show that there are several problems faced by OJK in carrying out its supervisory role, namely inconsistency in legal regulations related to supervision, limited human resources and technology and lack of coordination between BMT supervisory agencies and to optimize the role of OJK's supervision of BMT operational activities in Yogyakarta. First, legal factor, making laws and regulations and their implementing regulations needs to be explained in a detailed manner. Second, DPS needs to be increased further in order to maximize the implementation of the supervisory function. Third, OJK needs to encourage sharia financial service business actors, especially BMTs, to transform LKMS. Fourth, OJK needs support from the culture of the Yogyakarta community who have high Islamic spiritual so it can support the role of OJK supervision and development of BMT in Yogyakarta.
The Preamble Of The Constitution As A Constitutional Touchstone: Indonesian Practices
Authors: Rabbani Deden Rafi Syafiq , Abdurahman Ali , Susanto Mei
Published: September 2022

This paper aims to provide an analysis of two important things: First, the conception and use of the preamble to the constitution can be a constitutional touchstone. Second, the use of the preamble to the 1945 Constitution of the Republic of Indonesia as a constitutional touchstone in practice in Indonesia. This normative juridical research uses statutory approach, conceptual approach and case approach. The result is that as a constitutional touchstone, not only the values ​​in the preamble to the constitution are reflected in every constitutional provision, but are also used as a basis for constitutional interpretation, as well as a tool to test the validity of the law in resolving conflicting norms. Furthermore, in Indonesia the use of the Preamble to the 1945 Constitution as a constitutional touchstone is related to the legal position and status of the Preamble to the 1945 NRI Constitution as an integral part of the constitution as well as a foundation in establishing a constitution. The preamble to the 1945 Constitution is often used as a source of constitutional rights in the practice of judicial review at the Constitutional Court, as well as a tool in testing the legal validity of a statute.
Policy Directions For Animal, Fish And Plant Quarantine Institutions In The Administrative Structure
Authors: Rumainur Rumainur , Hidayat Henda
Published: September 2022

This research analyses how the Animal, Fish, and Plant Quarantine Law currently regulates quarantine and its institutions in positive law, the form and position of government institutions referred to in the Indonesian constitutional structure, and the direction of the government’s institutional arrangements is linked to Article 8 of the Quarantine Law. Animals, Fish and Plants in the Indonesian constitutional structure. Therefore, the form of government institution in the quarantine sector based on Article 8 of the Animal, Fish, and Plant Quarantine Law which is in accordance with the Indonesian legal system and constitutional structure is a Government Institution at the Ministry Level, considering the biosecurity function carried out in the implementation of quarantine. This normative legal research is supported by secondary data and analyzed qualitatively. From the results of the research, the government still needs to follow up on the regulation of animal, fish and plant quarantine and its institutions in the Animal, Fish and Plant Quarantine Law by drafting a Government Regulation Draft.
Independensi Aparat Pengawas Intern Pemerintah Guna Pelaksanaan Good Governance Berbasis CACM Di Lingkungan Pemerintah Daerah
Authors: Dewi Herlin Angela
Published: September 2022

This study aims to determine the independence of the government internal supervisory apparatus in order to realize the implementation of good governance in the Continuous Auditing and Continuous Monitoring (CACM) based local government environment. This normative juridical research show that CACM are tools that are expected to support the implementation of audits in order to produce effective and efficient audits. The research method used is normative juridicial. The results showed that APIP maintain independence and responsibility for supervision and guidance and be free from pressure from any party in order to realize reliable supervisory results the implementation of good governance in local government based on CACM.
Preventing and Protecting Against Internet Research Fraud in Anonymous Web-Based Research: Protocol for the Development and Implementation of an Anonymous Web-Based Data Integrity Plan
Authors: Hohn Kris L , Braswell April A , DeVita James M
Published: September 2022

Background

Data integrity is a priority in any internet research study; it should be maintained to protect the safety and privacy of human participants and to maintain the validity and reliability of research findings. However, one noteworthy risk of web-based research is fraudulent respondent activity. When investigators must utilize anonymous web-based recruitment techniques to reach hidden and expanded populations, steps should be taken to safeguard the integrity of data collected.

Objective

The purpose of this paper is to present a novel protocol in the form of an anonymous web-based research data integrity plan (DIP) protocol that outlines steps for securing data integrity while conducting anonymous web-based data collection.

Methods

In this paper, we discuss a protocol regarding the development and implementation of a specific DIP in response to fraudulent activity in an original large-scale mixed methods study launched in April 2021. Four primary steps, each with a set of affiliated procedures, are presented: (1) defining the risks, (2) planning research protocols, (3) securing data collection and recruitment, and (4) determining enrollment.

Results

Following the relaunch of a large-scale original study and implementation of the DIP protocol, preliminary analyses demonstrated no fraudulent activity. A pre-post analysis is underway to evaluate the effectiveness of the DIP strategies from February 2022 through May 2023.

Conclusions

Implementing the DIP protocol could save valuable research time, provides a process to examine data critically, and enables the contribution of rigorous findings to various health fields.

International Registered Report Identifier (IRRID)

DERR1-10.2196/38550
Cervical Myelopathy and Social Media: Mixed Methods Analysis (Preprint)
Authors: Elkaim Lior M , Levett Jordan J , Niazi Farbod , Alvi Mohammed A , Shlobin Nathan A , Linzey Joseph R , Robertson Faith , Bokhari Rakan , Alotaibi Naif M , Lasry Oliver
Published: September 2022

BACKGROUND

Degenerative cervical myelopathy (DCM) is a progressive neurologic condition caused by age-related degeneration of the cervical spine. Social media has become a crucial part of many patients’ lives; however, little is known about social media use pertaining to DCM.

OBJECTIVE

This manuscript describes the landscape of social media use and DCM in patients, caretakers, clinicians, and researchers.

METHODS

A comprehensive search of the entire Twitter application programing interface database from inception to March 2022 was performed to identify all tweets about cervical myelopathy. Data on Twitter users included geographic location, number of followers, and number of tweets. The number of tweet likes, retweets, quotes, and total engagement were collected. Tweets were also categorized based on their underlying themes. Mentions pertaining to past or upcoming surgical procedures were recorded. A natural language processing algorithm was used to assign a polarity score, subjectivity score, and analysis label to each tweet for sentiment analysis.

RESULTS

Overall, 1859 unique tweets from 1769 accounts met the inclusion criteria. The highest frequency of tweets was seen in 2018 and 2019, and tweets decreased significantly in 2020 and 2021. Most (888/1769, 50.2%) of the tweets’ authors were from the United States, United Kingdom, or Canada. Account categorization showed that 668 of 1769 (37.8%) users discussing DCM on Twitter were medical doctors or researchers, 415 of 1769 (23.5%) were patients or caregivers, and 201 of 1769 (11.4%) were news media outlets. The 1859 tweets most often discussed research (n=761, 40.9%), followed by spreading awareness or informing the public on DCM (n=559, 30.1%). Tweets describing personal patient perspectives on living with DCM were seen in 296 (15.9%) posts, with 65 (24%) of these discussing upcoming or past surgical experiences. Few tweets were related to advertising (n=31, 1.7%) or fundraising (n=7, 0.4%). A total of 930 (50%) tweets included a link, 260 (14%) included media (ie, photos or videos), and 595 (32%) included a hashtag. Overall, 847 of the 1859 tweets (45.6%) were classified as neutral, 717 (38.6%) as positive, and 295 (15.9%) as negative.

CONCLUSIONS

When categorized thematically, most tweets were related to research, followed by spreading awareness or informing the public on DCM. Almost 25% (65/296) of tweets describing patients’ personal experiences with DCM discussed past or upcoming surgical interventions. Few posts pertained to advertising or fundraising. These data can help identify areas for improvement of public awareness online, particularly regarding education, support, and fundraising.
Patient Perspectives and Preferences for Consent in the Digital Health Context: State-of-the-art Literature Review (Preprint)
Authors: Kassam Iman , Ilkina Daria , Kemp Jessica , Roble Heba , Carter-Langford Abigail , Shen Nelson
Published: September 2022

BACKGROUND

The increasing integration of digital health tools into care may result in a greater flow of personal health information (PHI) between patients and providers. Although privacy legislation governs how entities may collect, use, or share PHI, such legislation has not kept pace with digital health innovations, resulting in a lack of guidance on implementing meaningful consent. Understanding patient perspectives when implementing meaningful consent is critical to ensure that it meets their needs. Consent for research in the context of digital health is limited.

OBJECTIVE

This state-of-the-art review aimed to understand the current state of research as it relates to patient perspectives on digital health consent. Its objectives were to explore what is known about the patient perspective and experience with digital health consent and provide recommendations on designing and implementing digital health consent based on the findings.

METHODS

A structured literature search was developed and deployed in 4 electronic databases—MEDLINE, IEEE Xplore, Scopus, and Web of Science—for articles published after January 2010. The initial literature search was conducted in March 2021 and updated in March 2022. Articles were eligible for inclusion if they discussed electronic consent or consent, focused on the patient perspective or preference, and were related to digital health or digital PHI. Data were extracted using an extraction template and analyzed using qualitative content analysis.

RESULTS

In total, 75 articles were included for analysis. Most studies were published within the last 5 years (58/75, 77%) and conducted in a clinical care context (33/75, 44%) and in the United States (48/75, 64%). Most studies aimed to understand participants’ willingness to share PHI (25/75, 33%) and participants’ perceived usability and comprehension of an electronic consent notice (25/75, 33%). More than half (40/75, 53%) of the studies did not describe the type of consent model used. The broad open consent model was the most explored (11/75, 15%). Of the 75 studies, 68 (91%) found that participants were willing to provide consent; however, their consent behaviors and preferences were context-dependent. Common patient consent requirements included clear and digestible information detailing who can access PHI, for what purpose their PHI will be used, and how privacy will be ensured.

CONCLUSIONS

There is growing interest in understanding the patient perspective on digital health consent in the context of providing clinical care. There is evidence suggesting that many patients are willing to consent for various purposes, especially when there is greater transparency on how the PHI is used and oversight mechanisms are in place. Providing this transparency is critical for fostering trust in digital health tools and the innovative uses of data to optimize health and system outcomes.
Study on Socio-Economic of Peatland Community in Tanjung Jabung Timur Regency, Jambi
Authors: Surati Surati
Published: September 2022

This research  aimed to  analyze the socio economic and its dynamics of the community in Sidomukti Village, Dendang District, and Pandan Sejahtera Village, Geragai District, Tanjung Jabung Timur Regency, Jambi Province. Respondents were selected purposively based on their farming practices on deep peatlands. Thematic and descriptive analyses were used in this research. The results showed that the majority of the communities of the two villages was Javanese who came to the villages through transmigration programs in the 1980s. Their had insufficient knowledge about peatland utilization because they used to manage mineral soil in their place of origins. Their main jobs were farmers, planters, and laborers  with oil palm and areca nut as the main commodities. The average income in Pandan Sejahtera Village was IDR3,832,800/month, greater than in Sidomukti Village which was IDR3,661,850/month. Farmers tended to plant commodities that were currently favored in the market instead of their suitablility with the biophysical conditions of peatlands. Guidance is needed to improve farmers’ knowledge of land management and species selection that have high economic values and market captures as well as are suitable for biophysical properties of deep peatlands and agroforestry techniques.