bluuebunny/crossref_metadata_2025 huggingface dataset:
Max Depth Impact on Heart Disease Classification: Decision Tree and Random Forest
Authors: Rian Oktafiani  , Arief Hermawan  , Donny Avianto
Published: April 2024

Results in heart disease classification that are inaccurate and have low accuracy can endanger the patient's life. Some parameters in the algorithm model also influence classification. This study compares the Decision Tree and Random Forest algorithms for heart disease. The influence of maximum depth on heart disease classification also has significant implications. If the maximum depth is not set correctly, the classification results can be inaccurate and lead to incorrect diagnoses. This study uses five data split schemes, namely 60%: 40%, 70%: 30%, 75%: 25%, 80%: 20%, 90%: 10% and tested with different max depth parameters, namely max depth = 3, 4, 5, 6, and 7. This research produces the best accuracy using the 90%:10% scheme and max depth = 7 with the best accuracy result using the Random Forest algorithm of 99.29% while the Decision Tree algorithm is 98.05%. Then the precision and recall value of the Random Forest algorithm is 99% while the Decision Tree is 98%. The results of computation time using Decision Tree are faster than using Random Forest with a computation time for training data of 0.0075 s, while the testing data are 0.009 s. In future research, research can be conducted on the effect of other parameters by testing using several data sets.
Enhanced Yolov8 with OpenCV for Blind-Friendly Object Detection and Distance Estimation
Authors: Erwin Syahrudin  , Ema Utami  , Anggit Dwi Hartanto
Published: April 2024

The development of computer technology and computer vision has had a significant positive impact on the daily lives of blind people, especially in efforts to improve their navigation abilities. This research has the main aim of introducing a superior object detection method, especially in supporting the sustainability and effectiveness of navigation for the blind. The main focus of the research is the use of YOLOv8, the latest version of YOLO, as an object detection method, and distance measurement technology from OpenCV. The main challenge to be addressed involves improving the accuracy and performance of object detection, which is an important key to ensuring safe and effective navigation for blind people. In this context, blind people often face obstacles in their mobility, especially when walking around environments that may be full of obstacles or obstacles. Therefore, better object detection methods become essential to ensure the identification of nearby objects, which may involve obstacles or potential threats, thereby preventing possible accidents or difficulties in daily commuting. Involving YOLOv8 as an object detection method provides the advantage of a high level of accuracy, although with a slight increase in detection duration and GPU power consumption compared to previous versions. The research results show that YOLOv8 provides a low error rate, with an average error percentage of 3.15%, indicating very optimal results. Using a combined performance evaluation approach of YOLOv8 and OpenCV distance measurement metrics, this research not only seeks to improve accuracy but also efficiency in detection time and power consumption. This research makes an important contribution in presenting technological solutions that can help improve mobility and safety for blind people, bringing a real positive impact in facilitating their daily lives.
Effects of Interpersonal Psychotherapy on Postpartum Depression among Females at Tertiary Care Hospital Lahore
Authors: Arshad Sehrish , Afzal Muhammad , Sarwar Hajra
Published: April 2024

Introduction: Postpartum depression (PPD) is a major public health issue among females after giving birth to the baby, characterized by low mood, feeling of guilt and suicide. When left untreated, it has the potential for a profound negative impact on mothers, children and families. The efficacy of interpersonal psychotherapy (IPT) in addressing depression has been well-documented. However, the impact of IPT on PPD remains inadequately substantiated, particularly within the context of Pakistan, where data pertaining to its effectiveness remains limited. Objective: The aim of study was to assess the level of depression in postpartum females and evaluate the effects of IPT on PPD among females at tertiary care hospital Lahore. Methods: A Randomized controlled trial (RCT) was conducted at the Services Hospital Lahore from September 2021 to the same month in 2023. Subjects (n=110) were screened using the hamilton depression rating scale (HDRS) and divided equally in intervention group and control group to get eight sessions of individual based IPT versus routine care. Data was analyzed using SPSS version 21, intergroup comparison was done by Mann Whitney U test for intra group comparison Wilcoxon Signed Rank test was used, with 95% Confidence Interval (CI) and 5% level of significance. Significance of result showed with p value <0.05. Results: Prevalence of PPD among female was observed 82%. Upon receiving IPT, females exhibited a statistically significant reduction (p<0.001) in scores indicative of mild depression, from 48 (87.3%) to 5(9.1%), as well as for moderate depression, from 7(12.7%) to 1(1.8%). Furthermore, following the IPT sessions, marked improvements were noted within the intervention group across various domains including depressed mood p<0.001, CI (0.000, 0.027), feelings of guilt p<0.001, CI (0.000, 0.027), early night insomnia p<0.008, CI (0.000, 0.043), impaired work and activities p<0.05, CI (0.072, 0.200), and insight p<0.001, CI (0.000, 0.027). Conversely, the control group did not exhibit any significant alterations in these parameters. Conclusion: The results indicate a concerning prevalence rate of PPD among the study sample with many cases remaining undiagnosed and untreated. More positively, the study demonstrates the potential of IPT as an effective method to mitigate mild to moderate PPD. This research suggests the incorporation of IPT into therapeutic models could result in timely, potentially preventive interventions and lessen the occurrence of severe complications.
Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events
Authors: Assari Shervin , Sheikhattari Payam
Published: April 2024

Background: Exposure to stressful life events (SLEs) can upset balance and affect the healthy brain development of children and youths. These events may influence substance use by altering brain reward systems, especially the nucleus accumbens (NAc), which plays a key role in motivated behaviors and reward processing. The interaction between sensitization to SLEs, depression, and substance use might vary between male and female youths, potentially due to differences in how each sex responds to SLEs. Aims: This study aims to examine the effect of sex on the relationship between SLEs, Nucleus Accumbens activity, and substance use in a nationwide sample of young individuals. Methods: We utilized data from the Adolescent Brain Cognitive Development study (ABCD), a longitudinal study of pre-adolescents aged 9–10 years, comprising 11,795 participants tracked over 36 months. Structured interviews measuring SLEs were conducted using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Initial linear regression analyses explored if SLEs could predict volumes of the right and left NAc. Subsequently, Cox regression models were used to investigate how SLEs and NAc volume might predict the initiation of tobacco and marijuana use, with the analysis stratified by sex to address potential sex differences. Results: Our findings reveal that SLEs significantly predicted marijuana use in males but not in females, and tobacco use was influenced by SLEs in both sexes. A higher number of SLEs was linked with decreased left NAc volume in males, a trend not seen in females. The right NAc volume did not predict substance use in either sex. However, volumes of both the right and left NAc were significant predictors of future tobacco use, with varying relationships across sexes. In females, an inverse relationship was observed between both NAc volumes and the risk of tobacco use. In contrast, a positive correlation existed between the left NAc volume and tobacco and marijuana use in males, with no such relationship for females. Conclusion: This study underscores that the associations between SLEs, NAc volume, and subsequent substance use are influenced by a nuanced interplay of sex, brain hemisphere, and substance type.
Corrupção nas Índias espanholas
Authors: Pietschmann Horst
Published: April 2024

O surgimento do império espanhol entre fins do século XV e o reinado de Felipe II vai estritamente unido ao fenômeno da aparição do chamado “Estado moderno” ou “absolutista”. Enquanto os “homens do império” – ou seja, aqueles forjadores da preponderância espanhola na Europa e aqueles descobridores e conquistadores que ganharam aquele vasto império ultramarino – ainda estavam amplamente penetrados de ideias e conceitos de uma sociedade estamental baseada nos princípios de vassalagem e representatividade, a Coroa começava a fazer valer seu “poderio real absoluto”. Com o surgimento do Estado moderno, multiplica-se a legislação que submete os funcionários públicos a determinadas formas de proceder, de comportamento, de recebimento de soldos e direitos etc. Esta legislação frequentemente é publicada, impressa e incluída em compilações de leis, as quais, uma vez impressas, demandam o respeito ao bem público não somente da parte dos funcionários públicos, mas também do público em geral. Perguntamo-nos até que ponto se pode falar de “corrupção”, pelo menos na fase formativa do império, quando se presencia naquela época tão fundamental enfrentamento entre distintos conceitos político-sociais.

 

Tradução de Denis Guilherme Rolla (mestre em História do Direito, UFRGS). Revisão por Alfredo de J. Flores (Professor Permanente do PPGD-UFRGS). Os tradutores agradecem ao autor, o professor Horst Pietschmann, pela autorização e estímulo para esta tradução, em particular pelo contato com os colegas de Valladolid para efeitos dos direitos autorais. Ademais, para efeitos de adequação aos padrões da presente Revista, os tradutores incluíram os títulos “Introdução” e “Conclusão” e a numeração e breves títulos nas seções do texto, que não existiam no original.
O Processo de Adequação à LGPD
Authors: Teixeira Maria Luiza Firmiano , Moreira Pollyana Esteves dos Reis
Published: April 2024

Uma nova realidade se impõe à sociedade, com o mundo virtual tornando-se uma manifestação concreta. Diversas atividades que antes eram presenciais foram virtualizadas, trazendo consigo novas circunstâncias que requerem um enquadramento legal adequado. Nesse contexto, destaca-se a importância da chamada Lei Geral de Proteção de Dados (LGPD), que visa salvaguardar o direito fundamental à proteção de dados. A referida legislação é abrangente, atingindo também a Administração Pública, impondo ao complexo mundo do serviço público a obrigação de adaptar-se aos elementos inovadores da LGPD. As dificuldades nesse processo são inúmeras e demandam esforços significativos para alcançar a conformidade com as novas exigências. Assim, o presente estudo de caso objetiva apresentar o processo de adequação de uma instituição de ensino federal, multicampi, do interior de Minas Gerais. A metodologia empregada foi a pesquisa bibliográfica, com o diálogo entre as previsões legais, e o estudo de caso do plano de adequação da organização em análise. O trabalho apresenta uma introdução sobre o complexo contexto de adequação de todas as organizações, seguindo para o passo fundamental do processo, que é a indicação de um responsável, o encarregado de dados, detalhando o trabalho até a elaboração do plano de adequação. Após, apresenta-se o plano, seus êxitos e insucessos. Este trabalho contribui para o entendimento das dificuldades enfrentadas na prática, bem como pode servir de exemplo para outras organizações, encurtando os passos pelo aproveitamento de boas práticas.
Democracia Legislativa
Authors: Góis Breno Vinícius de , Carvalho Aline Estevam , De Medeiros Douglas Matias Marinho , De Paula Almeida Isadora Christine
Published: April 2024

Hodiernamente, percebe-se acentuado distanciamento entre cidadãos e seus representantes eleitos. O presente trabalho tem como objetivo principal verificar se a Câmara Municipal de Mossoró tem mecanismos de fortalecimento da participação popular no processo legislativo. Para tanto, realizou-se uma análise do processo legislativo no município de Mossoró/RN, buscando-se identificar ferramentas de participação cidadã na elaboração das leis, tanto as constitucionalmente previstas quanto as porventura criadas no âmbito municipal. Verificou- se a existência de instrumentos típicos e atípicos de participação popular, além da adesão moderada da população, no biênio 2021-2022, aos modos de participação encontrados: Tribuna Popular, Tribuna Solidária e Audiências Públicas. Verificou-se a existência de espaço para maior participação popular, apesar da constatação de participação relevante por parte dos cidadãos.
PRISÃO PREVENTIVA E A GARANTIA DA ORDEM PÚBLICA: ABSTRATIVIDADEE INSEGURANÇA JURÍDICA NA PRISÃO PREVENTIVA
Authors:   , SILVA ALEXANDRE MAIA DA , souza maria gisleide correia de , nascido gilvaneide gomes , barreto thallyta roberto da silva gomes
Published: April 2024

O presente trabalho tem como objetivo estudar o sentido da acepção de ordem pública e
por qual razão sua aplicação tem desencadeado insegurança juridica, quando utilizada
como fundamento na prisão preventiva. Inicio com a uma análise acerca da prisão
preventiva e em seguida da ordem pública. A partir das informações obtidas realize-se
uma reflexão sobre os fundamentos e pressupostos da prisão preventiva, e a legitimação
da ordem pública, no ordenamento juridico brasileiro; mostra-se como seus conceitos ao
longo do tempo tem-se sido usado como fundamento para a ordem pública.
J. H. KWABENA NKETIA NEXUS ENTRE PAN-AFRICANISMO, ETNOMUSICOLOGIA E CRÍTICA AO EUROCENTRISMO
Authors:   , ROSA PEDRO FERNANDO ACOSTA DA
Published: April 2024

A presente escritura busca investigar a obra do ganense Joseph Hanson Kwabena Nketia, considerado o fundador da Musicologia Africana e um dos grandes nomes da Etnomusicologia mundial, entre as décadas de 1950 e 1980, bem como os efeitos de sua visão Pan-Africanista na Etnomusicologia. Será analisada sua experiência musical, cultural, intelectual, política e sua visão sobre a Etnomusicologia através de artigos publicados em revistas especializadas de música. Entre os problemas levantados, estão (i) como os etnomusicólogos ocidentais viam o trabalho do ganense, que demonstrou certa dúvida em relação à intenção dos pesquisadores ocidentais ao fazerem pesquisa no continente africano, (ii) como ele é impactado pelos ideais Pan-Africanistas e (iii) o impacto político de seu trabalho para acadêmicos e instituições nas quais lecionou. O texto tem como referencial a teoria da Afrocentricidade e seu conceito de agencia (ASANTE; MAZAMA, 2005) e da Etnomusicologia Negra (ROSA, 2022). A partir da análise de textos, artigos, livros, entrevistas e homenagens póstumas ao autor. Proponho como um dos principais colaboradores para a Etnomusicologia Negra (ROSA, 2020). Além disso, trago o conceito de neXus, um ampliação do conceito de Nketia (1990), para referenciá-lo como uma das personalidades negras que trouxe para o campo musical questões politicas, sociais e de luta dos movimentos sociais negros na África e na diáspora Negra. Neste sentido, pretendo apontar caminhos teóricos e metodológicos para a Etnomusicologia Negra, contribuindo para a divulgação do autor entre pesquisadores não negros e, em especial, entre pesquisadores (as)negros(as), ainda carentes de referenciais negros no campo de estudos em música no Brasil. Por fim, este trabalho visa fomentar a valorização da lei 10.639/2003 que tange à contribuição dos africanos e de seus descendentes para a formação educacional, social, politica, cultural e econômica brasileira

Palavras-chave: ; J. H. Kwabena Nketia; ; musicologia africana; afrocentricidade.
A PRÁTICA PEDAGÓGICA DO PROFESSOR NOS ANOS INICIAIS E SUAS IMPLICAÇÕES NAS PRÁTICAS “INDISCIPLINARES” DOS EDUCANDOS
Authors: Silva Júnior Dilmar Rodrigues da
Published: April 2024

Apresentamos com entusiasmo o livro “A Prática Pedagógica
do Professor nos anos iniciais e suas implicações nas práticas
‘indisciplinares' dos educandos”, uma obra cuidadosamente
elaborada pelo conceituado pesquisador e docente Dilmar
Rodrigues da Silva Júnior. Neste livro, mergulhamos em uma
análise meticulosa da interação entre a prática pedagógica e a
ocorrência de comportamentos considerados “indisciplinados”
por parte dos alunos nos anos iniciais do ensino fundamental.
Em um cenário educacional dinâmico e multifacetado,
a questão da indisciplina muitas vezes desafia professores,
gestores escolares e pesquisadores. Dilmar Rodrigues da Silva
Júnior nos conduz por um percurso reflexivo, trazendo à luz
aspectos cruciais dessa dinâmica complexa. Através de uma
abordagem crítica e fundamentada em evidências, o autor nos
convida a repensar nossas concepções sobre a relação entre
prática pedagógica e indisciplina.
Ao longo das páginas deste livro, somos levados a refletir
sobre como as estratégias pedagógicas adotadas pelo professor
influenciam o comportamento dos alunos. A obra nos desafia a
considerar não apenas as manifestações externas da indisciplina,
mas também suas raízes profundas, muitas vezes enraizadas
em questões sociais, emocionais e pedagógicas.
MODEL BLACK-SCHOLES PUT-CALL PARITY HARGA OPSI TIPE EROPA DENGAN PEMBAGIAN DIVIDEN PADA PENUTUPAN HARGA SAHAM MEDIA NUSANTARA CITRA Tbk
Authors: PURNAMASARI NUR ASMITA
Published: April 2024

Investasi saham merupakan salah satu pilihan menarik bagi para investor. Selain memiliki saham secara langsung, investor juga dapat memiliki turunan dari saham, salah satunya adalah opsi. Model Black Scholes merupakan sebuah model yang berguna untuk menentukan harga opsi. Asumsi model ini adalah saham tidak memberikan pembayaran dividen, tidak ada biaya transaksi, suku bunga bebas risiko, serta perubahan harga saham mengikuti pola random. Tujuan penelitian ini adalah untuk menentukan model Black-Scholes harga opsi jual tipe Eropa dengan pembagian dividen dan put-call parity harga opsi tipe Eropa dengan pembagian dividen pada penutupan harga saham Media Nusantara Citra Tbk. Sehingga diperoleh Model Black-Scholes untuk harga opsi jual tipe Eropa dengan pembagian dividen pada keadaan constant market dan continous market masing-masing adalah   (S,t) = K N(-d2) – (S-q N(-d1), sehingga diperoleh (S,t) = Rp. 29,40 dan (S,t) = , sehingga diperoleh (S,t) = Rp. 38,02. Sedangkan Model Black-Scholes untuk put-call parity harga opsi tipe Eropa dengan pembagian dividen pada keadaan constant market dan continous market masing-masing adalah (S,t) + K  = (S,t) + (S ), sehingga diperoleh (S,t) = Rp. 202,43 dan , sehingga diperoleh (S,t) = Rp. 202,02
PENERAPAN SUPPORT VECTOR MACHINE (SVM) UNTUK KLASIFIKASI KABUPATEN TERTINGGAL DI PROVINSI MALUKU
Authors: Palisoa N. F. , Sinay L. J. , Matdoan M. Y. , Yudistira Yudistira , Bakarbessy Lusye
Published: April 2024

Daerah tertinggal merupakan daerah yang memiliki  masyarakat serta kondisi daerahnya kurang berkembang jika dibandingkan dengan daerah lain dalam skala nasional. Pemerataan pengembangan dan pembangunan daerah sangat penting untuk menjamin kesetaraan dan keseimbangan sosial ekonomi demi mencegah adanya daerah tertinggal. Provinsi Maluku merupakan salah satu daerah yang terletak di Kawasan Timur Indonesia dan merupakan salah satu propinsi dengan daerah tertinggal terbanyak yaitu sebanyak 6 kabupaten dari 11 kabupaten/kota. Untuk itu, perlu dilakukan pengklasifikasian wilayah agar dapat menentukan prioritas dalam pemerataan pembangunan yang cepat dan tepat sasaran. Salah satu metode statistika yang dapat digunakan dalam melakukan klasifikasi yaitu Support Vector Machine (SVM). Kelebihan SVM dibandingkan dengan metode lain adalah mampu menghasilkan model klasifikasi yang baik dengan akurasi yang lebih tinggi. Penelitian ini diperoleh hasil bahwa dengan menggunakan metode SVM diperoleh fungsi kernel terbaik yaitu fungsi kernel linear dengan parameter C=1 dan mampu mengklasifikasikan secara benar sebesar 76,13%. Sedangkan error rate model sebesar 23,87%, dimana kabupaten yang awalnya dikategorikan tidak tertinggal menjadi tertinggal ada 3 yaitu Kabupaten Maluku Tenggara, Maluku Tengah, dan Buru. Sementara kabupaten yang awalnya dikategorikan tertinggal menjadi tidak tertinggal juga ada 3 yaitu Kabupaten Seram Bagian Barat, Maluku Tenggara Barat, dan Maluku Barat Daya.
The Theological and Inculturative Values of Lamentation Songs In Good Friday Services
Authors: Panda Herman Punda
Published: April 2024

Many Christian communities in Sumba practice a unique tradition of incorporating lamentation songs in regional languages into their Good Friday services. These poignant melodies, born out of the local Christian community, trace their roots to the ngi'o teki tradition—a practice characterized by the expressive mourning of the departed through carefully crafted and emotional words. Despite the fact that such lamentations diverge from the official Good Friday services outlined in the widely accepted Roman Liturgy of the Catholic Church, they play a significant role in the cultural and religious fabric of these communities. This qualitative research aimed to delve into the historical and cultural context of these lament songs, unveil their theological and inculturative values, and discern their specific place within the Good Friday service. The findings of this research underscored the intrinsic theological and inculturative values embedded in lament songs, emphasizing their crucial role in rendering the Good Friday liturgy more resonant and meaningful for the local population.
Master of Science in Physics Education at The University of Guadalajara: The Curricular Design Process
Authors: Santana Fajardo José Luis , Vázquez Mercado Liliana , Rodríguez Pérez María Elena
Published: April 2024

Based on several educational needs related to Physics Education in Mexico, the University of Guadalajara began the curricular design of a Master’s Program in Physics Education. The work for the curricular design of the Master of Science in Physics Education at the University of Guadalajara was developed through nine phases. This paper presents the generalities related to the curricular design process of the Master of Science in Physics Education program at the University of Guadalajara. As a result, we have obtained a program creation project with 21 Learning Units integrated under a competency model and two research lines. Currently, while we are writing this work, the proposal is pending approval by the General Council of the University.
Current Trends in the Study of Promising Medicinal Plant Species
Authors: Sidelnikov N. I.
Published: April 2024

This publication presents the views of Nikolay I. Sidelnikov, Academician of the Russian Academy of Sciences, Director of the All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, on the current developments in the cultivation of medicinal plants, the search for and study of herbal drug sources, and the development of herbal medicinal products. The All-Russian Scientific Research Institute of Medicinal and Aromatic Plants carries out comprehensive studies of medicinal plants, including the evaluation of natural resources in the context of environmental management, the development of agricultural technologies, the search for biologically active substances, preclinical pharmacology and toxicity studies, and the development of technologies for the production of active substances and medicinal.
Chemical Composition and Clinical Potential of Shrubby Cinquefoil (Pentaphylloides fruticosa (L.) O. Schwarz) Shoots: A Review
Authors: Trebukhov A. V. , Dvornikova L. G. , Goryacheva M. V. , Maloletkina T. S.
Published: April 2024

INTRODUCTION. It is important to  study  medicinal  plants  that  are  not  listed  in the State Pharmacopoeia of the Russian Federation but are used in traditional medicine and represent an abundant source of raw materials.

AIM. This study aimed to collate data on the composition and pharmacology of the biologically active substances contained in shrubby cinquefoil (Pentaphylloides fruticosa (L.) O. Schwarz).

DISCUSSION. According to the reviewed literature, the underground and aboveground parts of P. fruticosa contain flavonoids, tannins, phenolic acids, triterpenoid saponins, and other compounds with significant therapeutic potential, which show antimicrobial, anti-inflammatory, and immunomodulatory properties. Most pharmacology studies of P. fruticosa bioactive metabolites investigate the modulating action they exert on innate and adaptive immune responses via various mechanisms. The majority of studies use different techniques and focus on the properties of crude extracts from morphologically different parts of the plant, which precludes meaningful comparisons of the results obtained in these studies.

CONCLUSIONS. P. fruticosa is a promising medicinal plant for inclusion in the pharmacopoeia. The plant has clinical potential as an antioxidant and an immunomodulator for the prevention and treatment of many diseases. The standardisation of Р. fruticosa herbal drugs requires thorough studies. The chemical composition of various plant tissues should be analysed with due consideration of seasonal, climatic, and anthropogenic factors.
Spectrophotometric Determination of Hydroxycinnamic Acids in Herbal Drugs. Part 1. Direct Spectrophotometry (Review)
Authors: Kompantseva E. V. , Ayrapetova A. Yu. , Saushkina A. S.
Published: April 2024

INTRODUCTION. Current scientific research aims to discover new plant sources of hydroxycinnamic acids for the development of novel medicinal products. Most commonly, the quantitative determination of hydroxycinnamic acids in herbal drugs involves testing procedures based on spectrophotometry and its modifications.

AIM. This study aimed to establish the possibility of the quantification of hydroxycinnamic acids in herbal drugs by direct spectrophotometry.

DISCUSSION. This review presents organised information on the use of direct spectrophotometry to quantify hydroxycinnamic acids in 70 plant species growing or cultivated in the Russian Federation. The review covers publications in Russian for the period from 2007 to 2023. According to the reviewed publications, direct spectrophotometry is an easy-to-use and highly reproducible method that does not require additional reagents or labour-intensive steps. Direct spectrophotometry may result in an overestimation of the hydroxycinnamic acid content due to overlapping absorption bands of polyphenolic compounds with different structures.

CONCLUSIONS. Direct spectrophotometry can be considered as a method for measuring the total content of phenolic compounds (as well as hydroxycinnamic acids) in herbal drugs. Different approaches to direct spectrophotometric quantification of hydroxycinnamic acids in herbal drugs by can serve as a methodological basis for developing analytical procedures specific to the chemical compositions of biologically active compounds in herbal drugs and their extracts.
Effect of Echinacea purpurea Herb Defatting on the Extraction of Hydroxycinnamic Acids
Authors: Lukashou R. I. , Gurina N. S.
Published: April 2024

INTRODUCTION. Currently the development of novel resourceand cost-effective extraction techniques for herbal medicinal products is a priority for pharmaceutical technology. A unique position among these herbal medicinal products belongs to the medicinal products of Echinacea purpurea, which stimulate the innate immune system.

AIM. The study aimed to investigate the effect of E. purpurea herb defatting on the extraction of hydroxycinnamic acids (HCAs) from the herbal drug and to evaluate the suitability of this treatment for the production of E. purpurea tinctures.

MATERIALS AND METHODS. On the basis of previous  experimental  findings, heptane was chosen as the defatting solvent. The production of E. purpurea tinctures included an additional step of herbal drug heating. The content of total HCAs was determined using a pharmacopoeial method, while the content of individual HCAs was determined using high-performance liquid chromatography. The residual defatting solvent was quantified by gas chromatography. The experiment used reference standards for HCAs.

RESULTS. The study showed that a single one-hour defatting treatment of the herbal drug with heptane at a 1 g to 5 mL ratio increased the yield of HCAs extracted from Е. purpurea herb. The optimal production process for E. purpurea tinctures involved grinding the herbal drug to 500–2000 μm, macerating the powder with 60% ethanol (v/v) at a 1 g to 10 mL ratio for 7 days, mechanically stirring the mixture for 60 min, and settling the crude extract for 3 days. Heating the herbal drug prior to extraction resulted in the highest yield of HCAs.

CONCLUSIONS. The newly developed production technology for E. purpurea tinctures with a preliminary defatting step increases the HCA content in the tinctures. This technology can be used for the industrial production of tinctures high in HCAs.
Recommendations for the Clinical Development of Medicinal Products for Non-specific Influenza Chemoprophylaxis
Authors: Gubenko A. I. , Ivanova O. Yu.
Published: April 2024

INTRODUCTION. The evolution of the influenza virus has led to a gradual decrease in the effectiveness of current antivirals. Better methods of prevention, detection, control, and treatment of influenza are needed, including more effective vaccines and antivirals. At the moment, the Russian Federation and the Eurasian Economic Union lack documents regulating the conduct of clinical trials of medicinal products for  influenza  prevention  and  require  that  guidelines  should  be  developed  for the matter.

AIM. The authors aimed to analyse the main regulatory approaches to preclinical and clinical development programmes for medicinal products for influenza prevention in the Russian Federation, the Eurasian Economic Union (EAEU), the European Union, and the United States of America.

DISCUSSION. This review substantiates the importance of non-specific influenza chemoprophylaxis in reducing the risk of adverse outcomes of the disease. The authors analysed the main stages of preclinical development of medicinal products for influenza prevention and  the  potential  contribution  of  preclinical  studies  to the planning of clinical trials. When developing preclinical and clinical programmes for medicinal products for influenza prevention, it is necessary, first of all, to take into account the requirements of the national good clinical practice guidelines and the EAEU guidelines for clinical trials in general. This article pays particular attention to the clinical trial designs used internationally, the possible options for their implementation, the characteristics of study populations, the formation of study groups, and the selection of primary and secondary endpoints.

CONCLUSIONS. The article proposes approaches to planning and conducting clinical trials of medicinal products for the prevention of influenza, taking into account the specifics of legal norms and clinical traditions of Russian practice. These recommendations will ensure high-quality data on the effectiveness and safety of investigational medicinal products and accelerate the introduction of new effective medicinal products for influenza prevention into medical practice.
Developing Primary School Students' Views on the Nature of Science by Storytelling
Authors: Ertaş Hakan , Bilican Kader
Published: April 2024

The study aimed to explore the development of third graders' nature of science views by using children's literature. The participants of the study was 18 third graders (12 F, 6 M) aged to 8-9 years old. The method of the study was a basic interpretive qualitative study and data were collected by means of open-ended questionnaires, reflective journals, and semi-structured interviews. The implementation of the study was taken for seven weeks and students enrolled in explicit -reflective nature of science activities coupled with childrens’ literature highlighting stories including nature of science. The results of the study showed that, primary students improved their NOS views mostly categırized as adequate or informed view.Our research findings revealed that, story telling could be a strong pedagogical tool in developing children’s nature of science views.
Blockchain in Health - From Pilots to Mainstream and Implications for AI
Authors: Krishnasamy, MS Sathya , Gopalakrishnan, PhD Badri , Apte, BSc Atul , Khurshid, MD, PhD MODERATOR: Anjum
Published: April 2024

Speakers delve into and beyond the previously published BHHTY journal article “Moving Beyond Proof of Concept and Pilots to Mainstream: Discovery and Lessons from Blockchain in Healthcare,” located at https://doi.org/10.30953/bhty.v6.280. This continuous enterprise blockchain technology journey extends the framework and solution assemblies including further developments, with cross over into generative AI and ethics.

Objectives

Learn specific examples on the economics of blockchain revealing low-hanging fruit for the move from pilots to adoption. Explore concepts such as:

Data integrity, minimal data, inter-entity streamlining leading to efficiencies, and what is already possible with tech stack developments and economics in efficiency (in millions) from the previously published BHTY article at DOI: https://doi.org/10.30953/bhty.v6.280

Learn from other verticals to build a framework that is more comprehensive encompassing global perspectives

Future proofing and stair-stepping design for an evolving technology – holistic guidance to find and execute the opportunities

Obtain a framework for blockchain adoption based on the article. In addition, authors address the academic view of blockchain adoption, and that it is a combination of tech, policy, economics, consumer engagement, and operationalization.

Acquire multi-dimensional discovery and specific blockchain constructs including provenance- consensus, trust maps, convergence, dApp human loops, and future proofing /stair-stepping

Grasp global perspectives on evolving frameworks with in many verticals and the multi-dimensional nature of blockchain transformation, operationalization, blockchain-enterprise landscape, and AI automation.

Gain a better understanding of why is blockchain an essential technology for the future of responsible AI and for scalability of solutions
Data Economy in Healthcare on Blockchain Technology
Authors: Yavuz Kevin
Published: April 2024

The importance of data and digitization in healthcare cannot be overstated. These advancements have the potential to revolutionize the way healthcare is delivered, leading to improved patient outcomes, enhanced efficiency, and better decision-making by healthcare providers. Blockchain technology can play a significant role in addressing the main challenges like data accessibility, privacy, interoperability and patient empowerment, ultimately transforming the healthcare ecosystem into a data-driven economy
Developing a Secure Internet-based Network of Trusted Data
Authors: Hardjono, PhD Thomas , Hudson, BSE Florence
Published: April 2024

Our world has not caught up with technology, and as a result has become more dangerous and nefarious with clandestine actors. Learn what reputable organizations, businesses and academic pioneers are doing to preserve digital identity, data provenance, universal access, and secure privacy-preserving transactions, to harness socially responsible global data sharing.
Educação em saúde bucal para crianças e adolescentes com deficiência auditiva
Authors: Monteiro Mariana Agra , Barbosa Heloísa Hannelore Diniz , Silva Neto Joab Custódio da , Dantas Lydiane dos Santos , Massoni Andreza Cristina de Lima Targino
Published: April 2024

Os autores relatam a experiência de uma ação de educação em saúde bucal voltada a crianças e adolescentes com deficiência auditiva, matriculados em uma escola referência para o ensino à comunidade surda de uma cidade de grande porte populacional localizada no estado da Paraíba, Nordeste brasileiro. Os alunos participantes de um projeto de Extensão Universitária conduziram a ação com o auxílio de três intérpretes da Língua Brasileira de Sinais (Libras), disponibilizados pela instituição. Destaca-se a divisão da ação em dois momentos: o primeiro, inicialmente destinado às crianças do primeiro ao quinto ano do Ensino Fundamental, por meio de dinâmicas que objetivaram trabalhar a importância da alimentação saudável, bem como orientações sobre a escovação e o uso do fio dental; e um segundo momento, realizado com os adolescentes do sexto ao nono ano do Ensino Fundamental, por meio de uma dinâmica de mitos e verdades sobre a saúde bucal, a fim de esclarecer sobre as principais dúvidas dos alunos. Ambos os momentos foram exitosos e garantiram a participação efetiva dos estudantes que se engajaram e partilharam muito conhecimento com os extensionistas. Desta forma, é notório o quanto a Extensão Universitária é uma atividade importante na formação acadêmica e humana dos futuros cirurgiões-dentistas e, principalmente, na devolutiva à comunidade de conhecimentos gerados na academia, oportunizando momentos ricos de educação em saúde.
ENHANCING GOVERNANCE THROUGH DIGITAL TRANSFORMATION
Authors: Zulmasyhur Zulmasyhur , Setiawan Heru Dian , L. W. Nicolaus Petrus
Published: April 2024

This research focuses on critical urgency considering the limited explanation in the literature regarding improving digital governance at the village level, especially in Penglumbaran Village, Bali, in the context of E-Government. This urgency arises primarily from the need to understand the practices implemented by village governments in realizing good governance that is responsive to the needs of all village residents. Meanwhile, the main objective of this research is to investigate and analyze improvements in digital governance in Penglumbaran Village, Bali, focusing on implementing E-Government and its impact on administrative efficiency, transparency, and community participation. Then, the descriptive analytical-qualitative method used in this research is supported by a desk study approach, where secondary data relevant to the research topic is used as the basis for analysis. In addition, through implementing the Online Digital Village Administration, Penglumbaran Bali Village has succeeded in increasing the accessibility of government services and strengthening village governance. It is illustrated in research findings, which positively impact efficiency, transparency, and community participation in government decision-making. Therefore, this research provides significance for understanding the effectiveness of digital governance in the context of E-Government at the village level. Thus, this research opens up the potential to support improvements in digital governance at the village level more broadly, aligning with modern government developments.
Penerapan Pencatatan Keuangan Sederhana Berbasis Digital pada UMKM ‘Sulton Bakery’
Authors: Lestari Intan Fatinah , Rahma Febriyanti  , Alda Rahmawati  , Kirani Anbiya Rizky , Johar Fikrul Haykal , Ade Nugraha  , Ahmad Alief Padlillah , Jamil Muhamad Wildan , Ramdhani Muhammad Rizky , Muhammad Rizal  , Rastari  , Jannah Siti Zahra Ma’watul , Farhan
Published: April 2024

The service program is carried out with the aim of providing MSME players with increased knowledge so that they can prepare digital bookkeeping and can prepare Profit and Loss Reports in accordance with applicable guidelines. The data collection method used in this community service program is a qualitative method that uses primary data. The data collection technique used is observation in the form of direct observation and interviews. This digital-based financial bookkeeping training was carried out using Microsoft Excel software. The implementation stages of this program consist of socialization, training and evaluation. As a result, this work program was successfully carried out because MSMEs were able to fill in the General Ledger independently every day and were able to prepare a Profit and Loss Report
Penataan Lingkungan Desa Cijemit Sebagai Upaya Memulihkan dan Memelihara Kelestarian Lingkungan
Authors: Manjaniawati Suchi , Inayah Khoirin , Mutmainah Diah Siti , Aprilia Hilda Nova , Zannah Tiara Rojatun , Aina Mila Hilmalia , Khoirunnisa Salma , Indah Sri , Askarimah Rizqa , . Taryana , Rizki Ari Muhammad , Maulana Aviv Ryan , Saputra Niko Ramdani , Farhan Miftahul , Yuliardi Ricki
Published: April 2024

Kuliah Kerja Nyata (KKN) merupakan bentuk kegiatan pengabdian kepada masyarakat yang dilakukan oleh mahasiswa dalam melaksanakan Catur Dharma Perguruan Tinggi Muhammadiyah Aisyiyah (PTMA) yakni aspek pengabdian. Melalui kegiatan KKN di Desa Cijemit, terjadi sinergi antara perguruan tinggi dengan masyarakat sebagai wujud pengetahuan demokrasi. Salah satu program yang dilakukan oleh mahasiswa KKN Desa Cijemit berdasar pada hasil observasi yang dilakukan adalah penataan lingkungan. Penataan lingkungan yang terdiri dari kegiatan kerja bakti di setiap dusun, kegiatan reboisasi (penghijauan kembali) dengan diberikannya 1.350 bibit, dan pemasangan papan nama gang sebanyak 50 papan nama gang. Sasaran program penataan lingkungan ini yaitu seluruh masyarakat Desa Cijemit. Metode kegiatan dilakukan dengan melalui tahap persiapan, pelaksanaan, dan evaluasi. Hasil pengabdian memberikan gambaran akan pentingnya dalam memulihkan dan memelihara kelestarian lingkungan dan dengan adanya kegiatan tersebut lingkungan sekitar terlihat lebih asri, bersih, dan tertata rapih.
Pelatihan dan Penyusunan Video Pembelajaran Proyek Penguatan Profil Pelajar Pancasila (P5) Berbasis Digitalisasi
Authors: Junaidi Teuku , Kurniawan Rizkei , . Mauliza , Rizki Azrul , Hidayat Muhammad Taufik , . Nuriana
Published: April 2024

Pembelajaran di Indonesia sedang menuju fase baru. Adanya perubahan kurikulum Pendidikan di Indonesia menjadikan guru harus berinovasi lebih aktif dalam menyelenggarakan pembelajaran. Kurikulum yang dilaksanakan sekarang adalah kurikulum merdeka yang memberikan kebebasan kepada peserta didik dan guru untuk mengembangkan kemampuan. Kurikulum merdeka memungkinan siswa untuk memiliki karakter sesuai dengan profil pelajar Pancasila. Mitra dalam kegiatan pengabdian yaitu SMP Negeri 4 Langsa melalui kepala sekolah menegaskan bahwa masih banyak guru yang tidak mengerti konsep kurikulum merdeka. Selain itu, saat ini di SMP Negeri 4 juga sangat minim guru yang menerapkan pembelajaran berbasis proyek di sekolah berbasis video maupun digitalisasi. Oleh karena itu, urgensi dalam pengabdian ini adalah memberikan edukasi kepada guru tentang kurikulum merdeka dan penguatan proyek profil pelajar Pancasila. Pengabdian ini bertujuan untuk memberikan pemahaman dan teknis pembelajaran penguatan proyek profil pelajar Pancasila dengan metode digital kepada guru di SMP Negeri 4 Langsa. Peserta pengabdian ini adalah guru SMPN 4 Langsa yang berjumlah 20 Orang. Adapun kegiatan pelaksanaan pengabdian ini melalui tiga langkah yaitu tahap persiapan, tahap pelatihan, dan tahap evaluasi. Berdasarkan hasil pengabdian ini adalah guru-guru SMPN 4 Langsa dapat memanfaatkan secara optimal penggunaan video pembelajaran dalam Pembuatan Portofolio Digital serta mampu mengimplementasi pelaksanaan penguatan P5 di sekolah.
Restorasi Satua Bali Yang Beredar Di Lingkungan Bebalang Untuk Menambah Bahan Literasi Di SD Negeri 3 Bebalang, Bangli, Bali
Authors: Luh Made Ayu Wulan Dewi  , Putu Beny Pradnyana  , I Wayan Numertayasa
Published: April 2024

AbstrakRestorasi satua Bali ini bertujuan untuk mengembalikan dan memperkenalkan kembali kebudayaan Satua Bali di SD Negeri 3 Bebalang hal yang dilakukan dalam restorasi satua bali ialah guru sebagai informan utama untuk memahami pengalaman mereka dalam melaksanakan Satua Bali. Sehingga menjadi dasar perencanaan restorasi, termasuk penyusunan kegiatan sosialisasi dan klinik Satua Bali guna meningkatkan pemahaman serta partisipasi anak-anak. Setelah observasi dan diskusi dengan guru tim klinik satua Bali melaksanakan sosialisasi untuk mengenalkan konsep restorasi Satua Bali kepada siswa dan meningkatkan minat mereka. Klinik Satua Bali dijalankan dengan menerapkan metode kualitatif menggunakan pendekatan Phenomenological Research agar peserta terlibat maksimal. Hasil dari klinik ini kemudian dicatat dalam buku “Restorasi Satua Bali” yang mencakup materi klinik satua Bali. Proses restorasi diteruskan dengan menggunakan media laptop untuk mengetahui satua Bali dengan jangkauan lebih luas, kemudian anak-anak diajak berkontribusi untuk mengikuti lomba Satua Bali sebagai wujud aplikasi praktis dari pembelajaran. Melalui pendekatan Phenomenological Research, restorasi Satua Bali di SD Negeri 3 Bebalang berhasil meningkatkan pemahaman budaya dan literasi anak-anak sehingga memberikan dampak positif pada pengembangan pendidikan budaya di sekolah SD Negeri 3 Bebalang. Kata kunci: Satua Bali, Literasi
Pendidikan Kesehatan Tentang Pijat Perineum Pada Ibu Hamil Trimester III
Authors: Istiana Siti , Kusumawati Erna , Rahmayani Alya Aulia , Aryana Dwi
Published: April 2024

Angka Kematian Ibu (AKI) di Kota Semarang dari tahun 2020 ke 2021 mengalami kenaikan dari 71,35/ 100.000 KH menjadi 95,30/ 100.000 kelahiran hidup dengan jumlah 21 kasus, dimana 16 kasus meninggal karena Covid. Pada tahun 2022 jumlah ibu yang meninggal turun menjadi 15 kasus dengan AKI 67,25 per 100.000 KH. Kematian ibu disebabkan oleh Perdarahan (40%), Pre eklampsi (21%), Sepsis (13%), Penyakit (13%), Lain lain (13%). Penyebab perdarahan dan infeksi bisa dikarenakan terjadinya laserasi perineum. Perlukaan pada perineum berefek pada kondisi fisik dan psikologis seorang wanita pasca persalinan. Wanita postpartum yang mempunyai luka perineum biasanya memiliki waktu penyembuhan yang relatif lebih lama. Beberapa penelitian telah dilakukan dalam hal tekhnik pemecahan masalah persalinan, terutama perlukaan jalan lahir. Hasil yang didapatkan adalah pijat perineum. Metode kegiatan adalah pendidikan kesehatan tentang pijat perineum Sasaran ibu hamil TM III di wilayah Puskesmas Tlogosari Kota Semarang. Pendidikan kesehatan diberikan dengan menggunakan media booklet dan leaflet. Metode pendidikan kesehatan dilakukan secara individu maupun kelompok. Pendidikan kesehatan dilakukan 2 kali, pertama  pada saat kunjungan ibu ke Puskesmas, yang kedua melakukan evaluasi melalui whatsapp atau telepon. Pada tahap akhir memberikan evaluasi kepada mitra mengenai pemahaman terhadap pijat perineum. Seluruh materi dapat disampaikan dan diterima dengan baik. Ada beberapa kendala yaitu masalah perizinan membutuhkan waktu yang lama serta ibu hamil yang datang ke Puskesmas tidak pada waktu yang bersamaan
Pembelajaran Berdiferensiasi dan Profil Pancasila dalam Kurikulum Merdeka: Persepsi Guru PAUD
Authors: Karimaliana Karimaliana , Agustina Agustina , Juita Novia
Published: April 2024

Guru PAUD harus dapaat memahami dan mengaplikasikan pembelajaran berdiferensiasi dan profil Pancasila sesuai tuntutan kurikulum merdeka. Penelitian ini bertujuan untuk mengetahui bagaimana guru PAUD menggali dan menganalisis persepsi guru pendidikan anak usia dini terhadap pembelajaran diferensiasi profil Pancasila dalam Kurikulum Merdeka. Pembelajaran berdiferensiasi dalam PAUD adalah melalui bermain secara eksplorasi, bermain konstruksi, bermain peran, bermain games, bermain menstimulasi. Dalam pembelajaran diferensiasi Profil Pancasila mengembangkan kognitif, psikomotorik, dan afektif anak yang disesuaikan dengan minat, bakat, dan disesuaikan dengan peserta didik. Studi kasus ini menggunakan metodologi kualitatif deskriptif. Penelitian  ini memanfaatkan analisis Miles Huberman. Penelitian ini melibatkan 30 guru PAUD, dengan 5 guru PAUD sebagai sampel. Metode purposive sampling digunakan untuk melakukan penelitian ini. Metode pengumpulan data yang melibatkan wawancara dan a ngket Penelitian ini menemukan dan menyimpulkan bahwa pandangan guru PAUD tentang pembelajaran diferensiasi profil pancasila dalam kurikulum merdeka adalah untuk memahami betapa pentingnya materi yang terkait dengan lingkungan belajar yang berkualitas.