bluuebunny/crossref_metadata_2025 huggingface dataset:
UNICORN STORIES IN TRACY CHEVALIER AND PHILIPPA GREGORY’S NOVELS
Authors: NISTOR Cristina Mihaela
Published: June 2022

Unicorn Stories in Tracy Chevalier’s and Philippa Gregory’s Novels. Unicorns have been described as mythological creatures that only the chosen ones could encounter. In the novels The Lady and the Unicorn by Tracy Chevalier and The Lady of the Rivers by Philippa Gregory, one such mythical beast evinces certain features that reflect on some of the characters in the novels. The paper discusses the image and symbolism of the mythological beast and analyses the depiction of the animal in the two novels written by the respective British authors. The stories told of the unicorn in the two books are to be compared and completed by texts from various other sources, in an attempt to get a fair picture of the way in which the two novels explore the legend of the respective magical creature, and transform it into feminist narratives.
Article history: Received 6 January 2022; Revised 7 May 2022; Accepted 13 May 2022; Available online 30 June 2022; Available print 30 June 2022.
REZUMAT. Poveşti despre unicorni în romanele lui Tracy Chevalier şi Philippa Gregory. Unicornii au fost descrişi drept fiinţe mitologice cu care doar cei aleşi se pot întâlni. În romanele Doamna şi unicornul de Tracy Chevalier și Doamna apelor de Philippa Gregory, o astfel de fiară mitică evidențiază anumite trăsături care se reflectă asupra unora dintre personajele din romane. Lucrarea discută despre imaginea și simbolismul fiarei mitologice, iar apoi analizează reprezentarea animalului în cele două romane scrise de autoarele britanice. Poveștile despre unicorn spuse în cele două cărți urmează să fie comparate și completate de texte din diverse alte surse, în încercarea de a obține o imagine corectă a modului în care cele două romane explorează legenda creaturii magice şi o transformă în naraţiuni feministe.
Cuvinte-cheie: unicorn, creatură mitologică, fecioară, doamnă, Chevalier, Gregory
THE BROWN BEAR IN THE NOVEL OF ION D. SÎRBU: FOLK-MYTHOLOGY IN THE SATIRICAL FABLE "THE DANCE OF THE BEAR"
Authors: POP Ionucu
Published: June 2022

The Brown Bear in the Novel of Ion D. Sîrbu: Folk-Mythology in The Satirical Fable The Dance of the Bear. Ion D. Sîrbu’s last anthumous novel, The Dance of the Bear, subtitled A Novel for Children and Grandparents, displays a highly nuanced understanding and symbolization of the animal world. This study aims to analyse the novel which, as the title suggests, abounds in animal imaginary, by focusing on its fable-like characteristics and the elements of Romanian folklore incorporated by the main prose writer of the Sibiu Literary Circle. Like most of Sîrbu’s anthumous works, The Dance of the Bear anticipates the critical and satirical attitude towards the totalitarian regime(s) that would later define the better-known posthumous books of Ion D. Sîrbu. The Aesopic dimension of the novel is facilitated by the clever instrumentation of the animal reference. One such reference is that of the Romanian mythological fauna, in the analysis of which, Mihai Coman’s Romanian Traditional Mythology proves to be revealing.
Article history: Received 14 February 2022; Revised 10 May 2022; Accepted 17 May 2022; Available online 30 June 2022; Available print 30 June 2022.
REZUMAT. Ursul brun în romanul lui Ion. D. Sîrbu: Mitologie populară în fabula satirică Dansul Ursului. Ultimul roman antum al lui Ion D. Sîrbu, Dansul ursului, purtând subtitlul “Roman pentru copii și bunici”, demonstrează o înțelegere și o simbolizare foarte nuanțate a lumii animale. Acest articol își propune să analizeze romanul care, după cum sugerează și titlul, abundă în imaginar animal, punând accent pe caracteristicile sale de fabulă și pe elementele folclorului românesc încorporate de principalul prozator al Cercului Literar de la Sibiu. La fel ca majoritatea operelor antume ale autorului în cauză, Dansul ursului anticipează atitudinea critică și satirică față de regimurile totalitare care avea să definească ulterior cele mai cunoscute cărți postume ale lui Ion D. Sîrbu. Dimensiunea esopică a romanului este facilitată de instrumentarea inteligentă a referinței animale. O astfel de referință este cea a faunei mitologice românești, în analiza căreia lucrarea lui Mihai Coman, Mitologie populară românească se dovedește revelatoare.
Cuvinte-cheie: Ion D. Sîrbu, Cercul Literar de la Sibiu, fabulă, mitologie populară românească, eco-etologie, literatură română postbelică, satiră
DIE ANTHROPOMORPHISIERTE GESTALT DES KATERS IM MÄRCHEN „DER GESTIEFELTE KATER” DER BRÜDER GRIMM UND DER MÄRCHENSERIE „PETTERSON UND FINDUS” VON SVEN NORDQVIST
Authors: SZÉLL Anita-Andreea
Published: June 2022

The Anthropomorphized Cat Figure in the Fairy Tale “Puss in Boots” by the Grimm Brothers and the Fairy Tale Series “Pettson and Findus” by Sven Nordqvist. This paper attempts to bring together three scientific fields that have always fascinated fairy-tale researchers and readers: fairy tales, psychology and anthropology. Almost all fairy tales deal with central stages and problems of human life. Thus, fairy tales, psychology, as well as anthropology deal with themes that reflect the reality of one's own person. The selected areas, which are intended to make the given analysis possible, serve to describe the way of life of the human hero and their animal companion and to describe both of their character developments, which take place with the help and thanks to the animal. Grimms’ Fairy Tales were the most published written works in the world after the Bible and the Quran. During that time, Children's and Household Tales caught the attention of several authors of world literature; therefore, some fairy tales of this collection served as the basis for numerous literary’ fairy tales. With these considerations and for these reasons, this article aims to analyse and draw comparisons between the Grimm fairy tale Puss in Boots and the fairy tale series Pettson and Findus by the Swedish author Sven Nordqvist.
Article history: Received 26 October 2021; Revised 18 November 2021; Accepted 27 November 2021; Available online 30 June 2022; Available print 30 June 2022.
REZUMAT. Figura antropomorfizată a motanului în povestea „Motanul încălțat” de Frații Grimm și în seria de basme „Pettson și Findus” de Sven Nordqvist. Această lucrare își propune să reunească trei domenii științifice care i-au fascinat dintotdeauna pe cercetătorii și cititorii de basme: basmul, psihologia și antropologia. Majoritatea basmelor tratează subiecte și probleme centrale ale vieții umane; atât basmele, cât și psihologia și antropologia abordează teme care reflectă realitatea propriei persoane. Domeniile selectate, pe a căror bază se structurează analiza servesc la descrierea modului în care eroii umani și companionii animali ai acestora își modelează viața și cum aceștia evoluează și se dezvoltă grație ajutorului unui animal. Culegerea de basme a fraților Grimm a fost a treia cea mai frecvent publicată scriere în lume, după Biblie și după Coran. De-a lungul vremurilor Poveștile Fraților Grimm au influențat mulți autori din literatura universală; unele basme din colecție au fost surse de inspirație pentru numeroase basme culte. Pe baza acestor considerente lucrarea de față își propune să realizeze o analiză comparativă între basmul din culegerea fraților Grimm Motanul Încălțat și seria de basme Pettson și Findus a autorului suedez Sven Nordqvist.
Cuvinte-cheie: Motanul încălțat, Findus, psihologie antropologică, antropomorfizare, analiză comparativă
"A Bounded and Incremental Design Approach to Public Administration: 30 Years after Shangraw and Crow’s Revolutionary Approach"
Authors:   ", YANG Lihua ,   Professor, School of Government, Institute of State Governance, and Institute of Public Governance, Peking University, Beijing, China"
Published: June 2022

Design is a living phenomenon of public administration, but it has not been thoroughly studied by students of public administration (PA). Based on the pioneering work by Simon in 1969, Shangraw and Crow set forth an approach to intellectual activity about public administration that they presented as a design science approach in 1989. This article explores the reasons for the faltering development of this revolutionary approach, proposes a new bounded and incremental design approach to public administration, and analyses the approach’s basic characteristics and six relevant ideas as well as the main research content and courses of public administration and some recommendations for PA practitioners under this new approach.
KEPEMILIKAN TUNGGAL PERSEROAN TERBATAS DALAM UU CIPTA KERJA BERDASARKAN TEORI BADAN HUKUM
Authors: Prasetyo Abigail
Published: June 2022

Perseroan Terbatas merupakan salah satu badan hukum yang diakui. Agar dapat dikatakan sebagai subjek hukum, tentu Perseroan Terbatas memiliki syarat-syarat tertentu sebelum akhirnya secara sah dinyatakan sebagai badan hukum dan cakap untuk melakukan perbuatan hukum. Ketentuan perundangan terkait Perseroan Terbatas yang telah diubah dari UU PT Tahun 2007 menjadi UU Cipta Kerja secara definitif telah mengubah makna badan hukum Perseroan Terbatas yang ada di Indonesia, yaitu dimana Perseroan Terbatas dengan kepemilikan tunggal. Tulisan ini hendak membahas implikasi dan resiko hukum yang dapat terjadi karena perubahan UU Cipta Kerja terhadap eksistensi badan hukum Perseroan Terbatas. Tulisan ini ditinjau berdasarkan teori badan hukum, karena pada Perseroan Terbatas dengan kepemilikan tunggal ini hanya memilik satu pemegang saham, maka secara otomatis berdasarkan teori badan hukum yang ada ciri khas pertanggungjawaban yang terbatas dalam Perseroan Terbatas tetap dipertahankan berdasarkan analisis teori badan hukum.
LEGALITAS INTERVENSI INTERNASIONAL BERDASARKAN PRINSIP RESPONSIBILITY TO PROTECT (R2P)
Authors: Pattisina Amanda Gita , De Sousa Freidelino P. R. A.
Published: June 2022

Diadaptasinya Responsibility to Protect (R2P) sebagai sebuah prinsip internasional pada UN World Summit 2005 menciptakan landasan baru bagi pemberlakuan intervensi internasional. R2P merupakan sebuah prinsip yang lahir dari adanya kekhawatiran akan kurangnya kesepahaman komunitas internasional tentang intervensi internasional yang kerap menghambat proses pengambilan keputusan, bahkan dalam situasi mendesak yang membutuhkan pengambilan tindakan sesegera mungkin. Membuka ruang bagi komunitas internasional untuk mengambil tindakan dalam bentuk intervensi internasional, tujuan utama prinsip R2P adalah memberikan perlindungan bagi penduduk sebuah negara dari atrocity crimes, yang mencakup kejahatan genosida, kejahatan terhadap kemanusiaan, kejahatan perang, dan pembersihan etnis, saat negara tersebut gagal memberikan perlindungan terhadap penduduknya. Meskipun begitu, intervensi internasional, apapun alasannya, hingga saat ini masih menuai kontroversi karena dianggap menciderai kedaulatan sebuah negara. Penelitian ini bertujuan untuk menegaskan bahwa intervensi internasional merupakan sebuah bentuk pertanggungjawaban komunitas internasional dalam upaya melindungi dan menegakkan hak asasi manusia dan bukan merupakan pelanggaran terhadap kedaulatan sebuah negara.
Family, friends and taxi drivers in hybrid networks. Integrating the immediate social environment into the Spiral of Silence Theory
Authors: Eilders Christiane , Gerads Marius , Scherer Helmut , Scheper Jule
Published: June 2022

The relative neglect of the immediate social environment is one of the best-known criticisms of the Spiral of Silence Theory (SoS). Due to massive changes in communication technology, especially the advent of social media, the immediate social environment has become even more relevant which has amplified this gap. This paper integrates the immediate social environment into the SoS. The immediate social environment is the aggregate of individual actors whom one interacts with – a mix of strong and weak ties. The immediate social environment is conceptualized as part of a larger ego-centric network of various sources or observers which also includes the mass media. Based on this concept, this paper examines the entire chain of effects – from monitoring the environment via different sources to the willingness to express one’s opinion in public in front of different observers. Particular attention is directed to the crosslinks between the immediate social environment and the larger realm of society and mass media. The integration of the immediate social environment serves the goal of further refining the conditions of a relevant social context under which people fear different types of social isolation from different groups and subsequently do or do not express their opinions.
Themenkonkurrenz in der Coronapandemie. Thematisierungsprozesse am Beispiel medialer Verdrängung der Themen «Klima» und «Geflüchtete» in der Coronakrise
Authors: Fretwurst Benjamin , Günther Elisabeth
Published: June 2022

In der vorgelegten Studie werden klassische Annahmen zur Drama-tisierungstendenz medialer Krisenberichterstattung bei gleichzeitiger Verdrängung übriger gesellschaftlich relevanter Themen auf den Prüfstand gestellt. Anwendungsbeispiel ist die Corona-Thematisierung (September 2019 bis Dezember 2020) und ihr Einfluss auf die Thema-tisierungsprozesse von «Klima» und «Geflüchtete». Anhand einer multivariat dynamischen Zeitreihenanalyse von 437 784 Onlineartikeln wird als übergeordnete Hypothese untersucht, ob Themenverdrän-gung festgestellt werden kann. Die Mechanismen der Verdrängung werden dann differenziert als phasenabhängige Aufmerksamkeits-verschiebung und als direkte also zeitgleiche Themenverdrängung untersucht. Die Ergebnisse bestätigen die Annahme der Themen-konkurrenz und zeigen je nach Thematisierungsphase unterschiedliche Verdrängungsprozesse. Im Trend hat Corona die Thematisierung der beiden anderen Krisenphänomene zwar nicht komplett verdrängt, aber sehr deutlich reduziert. Bezüglich der direkten Verdrängung sind Effekte messbar, aber eher klein. Als Fazit zeigt sich Themenverdrän-gung im Onlinejournalismus hier also eher als Effekt der Fokusver-schiebung öffentlicher Aufmerksamkeit als ein Problem direkter Ver-drängung aufgrund beschränkten Berichterstattungsraums.
In the following, classical hypotheses on the dramatization tendency of media crisis reporting and the assumed simultaneous suppression of other socially relevant topics are put to the test. For this case study, we rely on news reporting during the first year of the COVID19 pandemic (September 2019 to December 2020) to evaluate its influence on the thematization processes of «climate» and «refu-gees.» Based on a multivariate dynamic time series analysis of 437 784 online articles, we first confirm whether overall issue displace-ment can be detected and then delve deeper by differentiating into two possible mechanisms of displacement: 1) as a phase-dependent but global shift in attention and 2) as a direct i.e., simultaneous effect pointing toward editorial competition. Results from our analysis con-firm the overarching hypothesis of topic competition, clearly showing displacement processes depending on the thematization phase. Globally, while not being rendered invisible, media attention for the other two crisis phenomena was reduced significantly following the onset of the pandemic. Regarding direct displacement, effects are measurable, but rather small. We conclude that the displacement of media attention seems to be attributable more to a shift in public attention and overall trends than to classic assumptions based on limited resources in the editorial process.
The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD
Authors: Ochman Błażej , Kula Agnieszka , Świętochowska Elżbieta
Published: June 2022

Inflammatory bowel disease – Crohn's disease and ulcerative colitis – is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms of pathogenesis and pathophysiology. Intestinal epithelial barrier (IEB) dysregulation is one of the major underlying mechanisms of inflammatory process induction in IBD. Proper IEB integrity is maintained to a large extent by intercellular tight junctions, the function of which can be modified by many molecules, including miRNAs. MiRNAs belong to noncoding and non-messenger RNAs, which can modulate gene expression by binding predicted mRNAs.

In this review, we summarize and discuss the potential role of miRNAs in the regulation of inflammatory signaling pathways affecting the function of the intestinal epithelial barrier in IBD, with particular emphasis on therapeutic potentials. The aim of the review is also to determine the further development directions of the studies on miRNA in the modulation of the intestinal epithelial barrier in IBD.
TGF-β signaling in diabetic nephropathy: An update
Authors: Wang Li , Wang Hong-lian , Lan Hui-yao
Published: June 2022

Diabetic nephropathy (DN) is a common complication in patients with diabetes and the leading cause of end-stage renal disease. Accumulating evidence shows that transforming growth factor beta-1 (TGF-β1) is a key mediator in the pathogenesis of DN. TGF-β1 binds to its receptors to activate canonical and noncanonical downstream signaling pathways to exert its biological activities. Among them, canonical Smad signaling is the major pathway responsible for the development of DN. In addition to TGF-β1, many stress molecules, such as advanced glycation end products (AGEs), angiotensin II (Ang II), and C-reactive protein (CRP), can also activate Mothers against decapentaplegic homologs (Smads) via the extracellular signal-regulated kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) cross talk mechanism. Furthermore, TGF-β/Smad signaling can also cross talk with nuclear factor kappa B (NF-κB) signaling to regulate renal inflammation via the induction of IκBα by Smad7. In the context of renal fibrosis, Smad3 is pathogenic, while Smad2 and Smad7 are protective. TGF-β signaling also upregulates the pathogenic microRNAs (miRNAs) (namely, miR-21, miR-192, and miR-377) and long noncoding RNAs (lncRNAs) (namely, Erbb4-IR (intron region, IR), LncRNA9884, and Arid2-IR) but downregulates the protective miRNAs (namely, miR-29a/b and miR-200a) to mediate DN. Thus, targeting TGF-β signaling, either by blocking its ligand, its receptor (i.e., TGF-β receptor-2 [TGFBR2]), Smad3, and downstream miRNAs/lncRNAs or by overexpressing Smad7, has been shown to improve DN. In addition, pharmaceutically targeting TGF-β signaling using chemical inhibitors and traditional Chinese medicine (TCM), including Tangshen formula, Chaihuang-Yishen granule, and herbal extracts (berberine, asiatic acid, and naringenin), also shows renoprotective effect in diabetes. In summary, TGF-β signaling is a critical pathway leading to DN and may be a therapeutic target for combating DN.
Eating, drinking and travelling for fun. Backward to ‘Tourism and Gastronomy’ and forward to the Covidocene
Authors: Marques da Silva António José
Published: June 2022

Tourism and Gastronomy (T&G) was published in 2002. Even today, this book is an indispensable reference for researchers from different disciplinary perspectives who study how food and beverage are linked to leisure mobility. At that time, the contributors witnessed a major shift in consumer behaviour, which would soon turn the act of eating and drinking into a first-order driver of this sector of activity. The objective of the editors was to map the evolution of this new trend and predict the future of gastronomy and culinary heritage in tourism. This paper will revisit T&G to fully understand how, in only twenty years, what was before just a ‘non-optional’ part of the package became a prosperous niche, and later a primary component of recreational travels. The ‘throw-back’ approach adopted here will enable us to reflect on how the COVID-19 crisis impacts holidaymakers’ choices, which could help in the design of more efficient recovery plans.
Efficient way to ensure the data security in cloud computing
Authors: Pallikonda Anil Kumar , Chaduvula Kavitha , Markapudi Baburao , Jyothi Ch Rathna , Indira D N V S L S
Published: June 2022

This manuscript proposes a cloud data storage security, which has always been an important aspect of Quality of Service (QOS). Here, an effectual and flexible distributed scheme (DS) with Explicit Dynamic Data Support (EDDS) is proposed to ensure the accuracy of user data in the cloud. By using hemimorphic token with distributed verification of erasure-coded data, the proposed scheme achieves the integration of storage correctness insurance and data error localization. The proposed scheme supports secure and efficient dynamic operations on data blocks, such as data update, delete and append. The performance analysis shows that the proposed scheme is highly efficient.
Startups Funding Legal Regime
Authors: Costa Lopes Joana , Chen Chen
Published: June 2022

Because of their characteristics, startups are generally unable to access traditional forms of funding, such as bank loans. However, the global digital and technological revolution of recent years has enabled other forms of funding to emerge, offering alternatives to bank loans. These have allowed startups to fund themselves and so develop their business. This paper sets out to look at the alternative, technology-driven forms of finance used by startups and how these funding arrangements are regulated in the Portuguese legal system and in the European Union.
Cooperative Compliance: SWOT Analysis for the Brazilian CONFIA Program
Authors: Lopo Martinez Antonio
Published: June 2022

Cooperative compliance ensures that the taxpayer–Tax Administration relationship is based on transparency, mutual trust, and preventive actions of assistance and collaboration. These three foundations are formalized into six characteristics, two of which (transparency and disclosure) apply to taxpayers and five of which (commercial awareness, fairness, proportionality, transparency, and responsiveness) apply to the Tax Administration. This article discusses cooperative compliance concepts, requirements, advantages, tax control framework (TCF), tax risk, and governance issues. It then considers some Brazilian initiatives, highlighting the exposure of the CONFIA proposal as a cooperative compliance program of the Brazilian Revenue Service (RFB). Using a SWOT analysis based on international experiences, we discuss the strengths, weaknesses, opportunities, and threat points for success in implementing the CONFIA program. Additionally, we offer recommendations regarding how to ensure an environment of increasing cooperation in the tax field in order to reduce tax litigation, which is a chronic problem of the Brazilian tax system. Cooperation between taxpayers and Tax Administration should be based on the responsibility of both parties operating under mutual trust and not tolerating opportunistic behavior on either side of the tax relationship.
Endodontic retreatment of mandibular canines with two roots: A report of two cases
Authors:   Universidade Federal do Paraná, Curitiba, Brazil, Michelotto André , Oda Lisa ,   Universidade Federal do Paraná, Curitiba, Brazil, Yamamoto Ângela ,   Universidade Cruzeiro do Sul, São Paulo, Brazil, Cavenago Bruno ,   Universidade Federal do Paraná, Curitiba, Brazil, Batista Antonio ,   Universidade Federal do Paraná, Curitiba, Brazil
Published: June 2022

Mandibular canines usually have one root with one root canal. However, variations may occur. The present study reports two cases of successful retreatment of two mandibular canines with two roots and two root canals, a rarer configuration. In both cases reported, the unsuccessful treatment in the primary endodontic intervention was due to overlooking the lingual root canals, which were identified when periapical radiographs were taken at a mesial angle. Because canals missed during endodontic therapy may lead to periapical periodontitis, it is important to take radiographs from different angles, analyze the pulp chamber floor, and consider the variations in root canal morphologies. After performing the access cavity and observing an isthmus in both cases, the lingual root canals were located and instrumented. Calcium hydroxide dressing was used between appointments, and the root canals were filled with different sealers in each case (epoxy resin-based and bioceramic sealers). The follow-up X-rays taken 18 months later in the first case and 5 months later in the second case suggested normality of the periapical tissues. It is essential to use strategies that enable reaching the whole complexity of the root canal system during the canal cleaning, shaping, disinfection, and filling procedures in order to control the infection and achieve a successful endodontic treatment outcome.
Epithelioid hemangioma in the oral cavity: Report of a rare case
Authors:   Dentistry, Universidade Tuiuti do Paraná, Curitiba, PR, Brasil, Assis Fabiana , Mattos Natanael ,   Dentistry, Universidade Tuiuti do Paraná, Curitiba, PR, Brasil, Milani Cintia ,   Dentistry, Universidade Tuiuti do Paraná, Curitiba, PR, Brasil
Published: June 2022

The epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is a benign, neoplastic vascular tumor rarely presented in the mouth. It is most frequent in young adult male patients. Clinically, it is characterized by papules or nodules, usually with a reddish-brown color, mimicking other vascular and non-vascular lesions. Histologically, the lesion is composed of well-formed round vessels with epithelioid endothelial cells, with a histiocytoid appearance, surrounded by an infiltrate of lymphocytes and eosinophils. Oral EH’s endothelial cells are commonly immunoreactive for CD34 and factor VIII antigen. Surgical excision is the most widely used form of treatment, and recurrences are uncommon. The aim of this study was to report a rare case of oral EH in a 52-year-old female patient.
The Moderating Role Of Firm Size On Relationship Between Majority Ownership And Debt Policy Of Property Sector
Authors: Perdana Wahyu Santosa  , Harry Budiantoro  , Alyta Shabrina Zuzryn
Published: June 2022

This study aims to understand well the effect of majority ownership and firm size on financial fundamentals as controlling the debt policy of the property sector in Indonesia. The data panel model was built using data from firms listed in the property sector of the Indonesia Stock Exchange. Data is extracted from audited quarterly financial reports from 2014-2019. The results show that majority ownership negatively influences debt policy. In general, majority ownership negatively affects the capital structure in the short and long term because management is more prudent. However, sales growth and firm size insignificantly affect debt policy. Moreover, the moderate effect of firm size on the relationship between majority ownership and debt policy was strengthened. The controlling fundamentals, namely liquidity and profitability, negatively affect leverage. However, price to book value positively affects leverage. Our main implication is that majority ownership and firm size with firm-specific rather than country facts explain the differences in debt policy in the property sector.
Synthesis Characterization and Antimicrobial Activity of Mixed Ligand Complexes of L-ascorbic Acid and its Derivatives with Uracil Base
Authors: Malviy Kuldeep , Shrivastava Sarita , Sonwane Surendra
Published: June 2022

Some Organometallic Complexes of La (III), Ce (III), Nd (III), and Gd (III) with mixed Ligand of Uracil and L-ascorbic acid and its isopropylidine derivative were synthesized. Uracil complexes were prepared with some of the inner transition metals in a stoichiometric ratio of (1:1 v/v) (Mn+: L), where M3+ = La (III), Ce (III), Nd (III) and Gd (III) ions. The Complexes were characterized by the physicochemical and spectroscopic techniques as electric conductivity, metal contents, IR, UV–Visible, 1HNMR C13NMR, Mass Spectroscopy and molar conductance techniques. The stoichiometric ratios of the synthesized complexes were confirmed by using molar ratio method. The dissociation constant of Uracil ligand was determined spectro-photometrically. Solvent effect on the electronic spectra of the Uracil ligand was examined using solvents with different polarities. In addition, biological activity of the synthesised metal complexes against Salmonella typhi, Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia bacteria and Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride fungi respectively were examined in-vitro.
Isolation of Ferulic Acid - A Bioactive Phenolic Compound from Pineapple Peel and Evaluation of its In-vitro Anti-inflammatory Potential
Authors: Lubaina Abdulhadeef S. , Renjit Pallathu R. , Ananthakrishnan Ramamoorthy , Nair Ragesh R.
Published: June 2022

Fruit wastes and their byproducts may cause serious environmental problems, since it accumulates in agro-industrial yards without having any significant and commercial value. Pineapple(Family - Bromeliaceae) is one of the leading edible tropical fruit produced in the world. Pineapple peel is the massive waste produced by the pineapple processing industry leading to environmental pollution. In this regard, efforts have been made in order to tap the potential of this bio-waste as source of bioactive compounds by isolating, purifying and characterizing known as well as novel secondary metabolites from it and can be used for studying its application in various industries. A phenolic compound namely Ferulic acid is isolated from this bio-waste and its structure has been elucidated by Fourier Transform Infrared (FT-IR) spectroscopy, Liquid Chromatography-Mass Spectrometry (LC-MS), High Performance Liquid Chromatography (HPLC), 1H NMR and 13C Nuclear Magnetic Resonance (NMR) spectra. The anti-inflammatory potential of Ferulic acid was studied in vitro on Lipopolysaccharide (LPS) stimulated Ralph and Williams (RAW) and Tamm-Horsefall Protein-1 (THP-1) cell lines. The levels of pro-inflammatory enzymes such as cyclooxygenase (COX), lipooxygenase (LOX), and myeloperoxidase (MPOX) activities on THP-1 cell lines and the tested compound, exhibited a dose-dependent anti-inflammatory activity. Ferulic acid showed remarkable activity by COX (78.47%) and LOX (78.63%) inhibition in LPS stimulated THP-1 cells at 100 μg/mL. Different concentrations of Ferulic Acid (FER) effectively decreased the MPOX (92.76℅) level in a dose dependent manner and the results were comparable to standard drug Indomethacin. The isolated phenolic compound, ferulic acid, effectively lowered inflammatory cytokines like Tumour Necrosis Factor Alpha (TNF-α), Interleukin-6 (IL-6) and Interleukin-1 Beta (IL-1β) along with prostaglandin E2 and leukotriene C4 and cellular nitrate levels in LPS stimulated RAW cells.
Effect of Ethanolic extract of Boerhhvia diffusa against Doxorubicin induced Nephrotoxicity in Albino rats
Authors: Nimbal Shrishail K. , Koti Basavaraj C.
Published: June 2022

Anthracycline derivative i.e. doxorubicin (Dox) has proven efficacy in several malignancies such as breast cancer, Hodgkin and non-Hodgkin lymphoma, acute leukemia, lung, thyroid and ovarian cancer. The clinical usefulness is restricted due to its cardiotoxicity and nephrotoxicity. Boerhaavia diffusa belongs to family Nyctaginaceae and in Ayurveda, it is claimed for use in renal disorders.The main phytoconstituents of the plant are alkaloids, terpenoids, tannins, glycosides, flavonoids, phenolic compounds. To investigate the ameliorative role of ethanolic extract of petals of B. diffusa in doxorubicin-induced nephrotoxicity in rats. Nephrotoxicity was produced by administering doxorubicin (2.5 mg/kg b.w., i.p. alternate day) in six equal injections for two weeks to become cumulatively 15 mg/kg. Low (LEBD–100 mg/kg p.o.)and high (HEBD–200 mg/kg p.o.) dose of ethanolic extract of Boerhhvia diffusa was administered as a pretreatment before doxorubicin administration. The general parameters such as body weight, food, and water intake were measured throughout the study period. Serum markers such as blood urea nitrogen (BUN), serum creatinine and albumin were measured. Antioxidant enzymes such as glutathione (GSH), malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) were monitored after the last dose. Histopathological studies were also carried out to evaluate nephrotoxicity. The repeated administration of doxorubicin produces several morphological changes, decreased body weight, food, and water consumption. Serum markers such as BUN and serum creatinine were increased and albumin levels decreased. The GSH, SOD, and CAT were decreased, whereas the MDA level was increased, and deteriorating changes in the histological architecture of kidney tissue were observed. The HEBD pretreated groups dose-dependently increased body weight and food and water intake (p < 0.01 and p < 0.05), whereas LEBD does not show any significant changes. The LEBD and HEBD pretreated groups decreased the BUN (p < 0.05 and p < 0.01) and serum creatinine (p < 0.05 and p < 0.05) and increased in the albumin (p < 0.05 and p < 0.05) levels, respectively. The pretreatment with LEBD and HEBD increased the level of the antioxidant enzyme i.e., GSH (p < 0.05 and p < 0.01), SOD (p < 0.05 and p < 0.01), CAT (p < 0.05 and p < 0.01) and decreased the MDA level (p < 0.05 and p < 0.01) respectively. Histopathological studies showed that the pretreatment with LEBD and HEBD groups minimized the tubular damage and reduced the inflammation as compared to doxorubicin-treated group. The biochemical and histopathological results data support the nephroprotective effect of ethanolic extract of B. diffusa, which might be credited to its antioxidant property.
In-vitro Antimicrobial Activity of Novel Quinazoline Derivatives: One-Pot Synthesis and Characterization
Authors: Reddy Anam R. , Reddy Tumuluru R.
Published: June 2022

Designing an efficient class of novel antimicrobial agents becomes an enormous task in pharmaceuticals research and development. Current research work comprised of finding a novel series of various substituted quinazoline derivatives. The synthetic scheme involves single-step, one-pot synthesis involving the condensation of highly activated aromatic amide starting materials with weakly nucleophilic alkyl nitriles to directly provide the corresponding quinazoline derivatives employing trifluoromethanesulfonic anhydride catalyst. All the synthesized compounds were characterized by IR, proton nuclear magnetic resonance (1HNMR) and message, audience, situation, significance (MASS) spectral methods and screened for antimicrobial activity against four bacterial strains Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and two fungal strains Aspergillus niger and Candida albicans. All the compounds displayed decent antimicrobial profile when compared with the standard drugs neomycin and nystatin. Among the synthesized compounds (3a1-3a5&3b1-3b5) evaluated, compounds 3a1, 3a2, 3a3, 3b1and 3b2 have demonstrated decent antimicrobial activity against selected strains of bacteria and fungi.
Syringic Acid Reversed Depression-Resembling Behavior Induced by Chronic Unpredictable Mild Stress Paradigm in Mice
Authors: Sharma Abhishek , Dhingra Dinesh , Dutt Rohit
Published: June 2022

The aim of the present investigation was to explore the anti-depressive potential of syringic acid in Swiss albino male mice. Mice were exposed to unpredictable stress for 21 sequential days. Imipramine (15 mg/kg, p.o.) and syringic acid (10 and 20 mg/kg, p.o.) were administered for three consecutive weeks to unstressed and stressed mice. Tail suspension test and sucrose preference test were used to evaluate antidepressant potential of the drugs. Syringic acid and imipramine significantly decreased immobility periods of stressed mice as compared to vehicle treated stressed mice in tail suspension test, indicating their antidepressant effects. Syringic acid (20 mg/kg) and imipramine also significantly restored the reduced sucrose preference (%) in stressed mice, which further substantiated their antidepressant effects. Syringic acid and imipramine did not produce significant antidepressant effects in unstressed mice. These drugs did not significantly affect locomotor activity scores of mice. Syringic acid (20 mg/kg) and imipramine significantly reversed chronic unpredictable mild stress (CUMS)-induced increase of plasma nitrite and corticosterone levels; brain malondialdehyde levels and monoamine oxidase (MAO(-A activity. Both the drugs also significantly reversed CUMS-induced decrease in brain reduced glutathione levels and catalase activity. Thus, syringic acid showed significant antidepressant-like activity in mice subjected to CUMS through alleviation of oxidative and nitrosative stress; and inhibition of brain MAO-A activity. Further, antidepressant-like activity of syringic acid in mice subjected to CUMS might also be due to decrease in plasma corticosterone levels. Fig. 1 Illustrates further the scheme of protocol designed with various groups of animals.
Formulation and Optimization of Polyherbal Fast Dissolving Tablet of Curcumin, Quercetin and Rutin
Authors: Tiwari Reshu , Siddiqui Mohd. Haris , Mahmood Tarique , Farooqui Alvina , Tiwari Mukesh , Ahsan Farogh
Published: June 2022

The current study was focused on the design, development, and evaluation of the fast-dissolving tablet of a polyherbal combination of curcumin, quercetin, and rutin. These herbal drugs are poorly water-soluble. The center of attention for this study is to provide quick onset of action, improved bioavailability, and increased patient compliance for administering a tablet. All parameters of Polyherbal Fast dissolving tablets were evaluated, and all were found within the official range. Drug content ranges between 90 to 105%. The formulation PHT24 containing a high concentration of Crosspovidone enhanced the drug release up to 94% within 5 minutes compared with the control. The optimized formula PHT24 showed favorable drug dissolve characteristics with better mouth feel and acceptable fast-dissolving properties. It was also observed that all formulations were acceptable with reasonable limits of the standard required for fast-dissolving tablets. The study also reveals that the Superdisintegrants used were effective in low or high concentrations. It was concluded that fast dissolving tablets with enhanced dissolution rates could be made using selected Superdisintegrants.
Studies on Nephroprotective Effect of Methanolic and Aqueous Extract of Bark of Pithecellobium Dulce Roxb. in Rats
Authors: Patil Ravindra , Yamgar Surekha
Published: June 2022

Kidney failure is a major problem of worldwide proportions. Kidney injury is a sudden loss of kidney
function resulting in the accretion of waste materials such as creatinine and urea in the body. There
are various agents that exert nephrotoxic effects through distinctive morbific defence mechanisms.
Gentamicin, cisplatin and paracetamol are among common nephrotoxicity agents. In recent years, natural
compounds are being expanded used in the treatment of kidney diseases. With this backdrop the study
has been designed with the aim to studies on nephroprotective effect of methanolic and aqueous extract
of bark of Pithecellobium Dulce Roxb. in rats. The methanolic and aqueous extracts of bark of P. Dulce was
studied for nephroprotective effect in female Wistar rats against cisplatin, gentamicin and paracetamol
induced nephrotoxicity, by estimating serum creatinine, blood urea and serum albumin levels. The dried
bark of P. Dulce, Roxb (Leguminosae), contains tannins, flavonoids, triterpenoids, beta-sitosterol and
saponin glycoside. Treatments with the methanolic and aqueous extracts could significantly (P is less than  0.001) reduce the elevated serum levels of creatinine, blood urea and serum albumin. P. Dulce bark extracts
significantly prevented the physical, biochemical, histological and structural changes induced by cisplatin,
gentamicin and paracetamol in the kidney. The present study reports with the exploration of P. Dulce bark
extracts possessed implicit nephroprotective activity. This activity may be attributed due to the abundant
phytoconstituents of the plant extracts.
Alkaptonuria: diagnostic odyssey unraveling a rare metabolic disease
Authors: Camara Daniely , Lima Isabela , Silva Julia , Rocha Tharcila , Schneider Fabiana , Fonseca Jacqueline , Carneiro Zumira , Lourenço Charles
Published: June 2022

INTRODUCTION: Alkaptonuria is a rare autosomal recessive disorder due to the deficiency of the enzyme homogentisic-oxidase, produced by the liver and kidneys, which is involved in phenylalanine and tyrosine metabolism. In the absence of this enzyme, the accumulation of ochronous pigment occurs. The most important clinical manifestations of ochronosis are arthropathy, ocular and cutaneous pigmentation, dark urine and cardiovascular involvement. Nitisinone (NTBC) is a benzoylcyclohexane-1,3-dione that reversibly inhibits the activity of the enzyme step immediately before the homogenized dioxygenase, thereby reducing the production of homogentisic acid (HGA). Thus, it is considered that nitisinone may be a potential treatment for alcaptonuria. Here we report the first Brazilian patient treated with NTBC after a misdiagnosis of congenital porphyria. CASE REPORT: Male patient, referred for evaluation of urine darkening at two years of age, was diagnosed with alkaptonuria at 3 years of age. At 8 years of age, he was started on NTBC therapy with markedly homogentisic acid decrease. Tyrosine increase and ocular pain were noticed and were managed reducing NTBC dosage. DISCUSSION: Although considered a typically adult disease, the symptoms of alkaptonuria begin in childhood and have a progressive and devastating course. Early diagnosis of this disease allows the implementation of therapeutic measures, such as the use of NTBC, preventing the progression of disease manifestations and the appearance of irreversible sequelae.
Morquio A syndrome: differential diagnosis of disproportionate short stature
Authors: Ferreira Juliana , Silva Kaio , Ventureli Kimbali , Goulart Leticia , Rodrigues Mariana , Carneiro Zumira , Streit Júnior Rosalvo , Lourenço Charles
Published: June 2022

Short stature is defined as a condition in which the height of the individuals is below the third percentile or two standard deviations below the expected average for children of the same age and sex. Bone dysplasias are an important group in the differential diagnosis in children with short stature and, among them, Morquio A syndrome, a genetic-metabolic disease, characterized by an enzyme deficiency and lysosomal accumulation with a direct impact on bone development and cartilaginous. Often, this pathology goes unnoticed by the endocrinologist or pediatrician when evaluating children with short stature, mainly because the classical signs and symptoms of the disease are not yet evident. Morquio A syndrome is not curable, but early diagnosis and treatment make it possible to prevent disease progression and provide better quality of life for patients. The currently available treatments are hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (TRE). In addition, due to the various disabling comorbidities that can arise with evolution, a multidisciplinary approach is essential. Knowledge of genetic causes of short stature due to alteration in bone development is fundamental for the clinical suspicion of this group of diseases. This article aims to report the case of three siblings with the syndrome, whose diagnosis of two of these patients took more than two decades to be established.
Stroke in children: a historical overview in Brazil
Authors: Kalil Neto Felipe , Ribeiro Maria Valeriana , Schmidt Fernanda , Massaro Ayrton
Published: June 2022

Stroke in infancy is a prevalent disease and a significant cause of morbidity in children. The etiologies are diverse and multi-factorial. Despite its importance, this disease and its recognition was until recently overlooked and understudied. The main objective of this historical note is to describe and to highlight the contribution of different authors for the recognition of pediatric stroke in Brazil.
ODD: behavioural perspectives and their association with ADHD and CT
Authors: Silva Taynara , Fontoura Julia , Carvalho Viviane , Maia Glenia
Published: June 2022

Oppositional defiant disorder (ODD) is characterized by impulse and conduct control disorders and aggressive behavior. It is often associated with other disorders, especially conduct disorder (CT) and attention deficit hyperactivity disorder (ADHD). This is an integrative review of medical literature of a qualitative nature, which aims to present what are the perspectives for a patient with OCD and its main associations: CT and ADHD. These psychopathologies directly influence the personal and professional relationships of individuals and are associated with a greater propensity to aggression, crime and theft when not controlled. Therefore, it is essential to diagnose these disorders and promote the necessary interventions.
Impacts of the National Innovation System on the Star-Up Ecosystem: The Case of the Southern Key Economic Region
Authors: Lien Tran Thi Hong
Published: June 2022

It has been over two years since the outbreak of the Covid-19 pandemic. Various weaknesses of the global economic system that had existed before the pandemic have been exposed, and the need for an innovation system has become prominent. This research is aimed at finding such a system at a smaller scale for a key economic zone. Utilizing the theory of a national innovation system and content analysis method based on publications, the research shows that the Southern Key Economic Region can solve the bottleneck that weakens its pioneering position in the country’s economy by promoting its local innovative start-up ecosystem. The ecosystem is currently at the stage of activation (the earliest level in a four-stage lifecycle of activation, globalization, attraction, and integration). In order to move to the next level of globalization, in parallel with other general policy supports, the region should select some start-up sub-sectors to develop, using public procurement as leverage for start-ups.
Determinants of Intention to Purchase Electric Cars in Vietnam: Proposing an Analysis Framework from Theoretical Research
Authors: Hoang Truong Trong
Published: June 2022

The intention to purchase an electric car can be explained in two ways: the intention to adopt a new technological product, and the intention of green consumption. Based on the theoretical research on customer behavior and a literature review, an analytical framework on the intention of Vietnamese consumers to purchase electric cars is proposed. The framework is developed by integrating the Unified Theory of Acceptance and Use of Technology (UTAUT) and the Norm Activation Model (NAM). According to the framework, a consumer’s intention to purchase is influenced by performance expectancy, effort expectancy, social influence, facilitating condition, personal norm, and an ascription of responsibility and consequence awareness. Besides contributing a theoretical framework on the consumer’s purchase intention, the article also proposes some suggestions for manufacturers and policymakers in promoting electric cars in the Vietnam market.
Internal Factors Affecting Green Procurement of Food and Beverage Firms in Vietnam
Authors: Giang Do Huong , Huyen Le Ngoc Khanh , Trang Luyen Thu , Giang Nguyen Quynh , Linh Tran Phuong
Published: June 2022

The main purpose of this study is to explore the internal factors affecting the green procurement of Food and Beverage (F&B) enterprises in Vietnam. The official study was conducted with 235 F&B enterprises operating in Vietnam through direct and online survey methods. The research results have identified five internal factors that directly affect green procurement activities, including: (i) Corporate social responsibility, (ii) Business strategy, (iii) Quality human resources, (iv) Information technology and (v) Management awareness and commitment. In particular, the quality of human resources is the factor that has the most positive and strongest influence on the green procurement activities of enterprises in the F&B industry in Vietnam.