bluuebunny/crossref_metadata_2025 huggingface dataset:
Notas sobre la representación del espacio dramático en la comedia de Aristófanes
Authors: Schere María Jimena
Published: April 2024

In this article I propose an exegetical and philological commentary on Bacchylides’ Epinician 3 accompanied by a poetic translation that incorporates the results into the target text in Brazilian Portuguese. My intention with this commentary is not only to draw the reader’s attention to the sophistication and complexity that underlies the apparent simplicity of Bacchylides’ poetry, but also to present new critical results regarding the poem’s exegesis. In the commentary, therefore, I explain my reasons for changing the textus receptus of Kenyon (1897) and Maehler (2003) at certain points, to reflect the advances made by textual criticism in recent years, as well as my own interpretation of certain passages. In this commentary, I also explain my translation choices whenever they diverge from more traditional ones.
Philosophy and Sociology of Law by Bogdan Kistyakovski
Authors: Trunov F. O.
Published: April 2024

The article tries to explore the importance of the work «Philosophy and sociology of the law» by Bogdan Kistyakovsky for the political science and theory. The article shows the positioning of the intelligentsia in Kyiv as part of Russian Empire, its critical attitude to the ideas of Ukrainophilism. The author stresses the political proximity of Bogdan Kistyakovsky to the political party of constitutional democrats (cadets). In his work Kistyakovsky tried to show the advantages of the rule of law, the possibility of its establishment in the Russia of that time. The article considers the contribution of the «Philosophy and sociology of the law» to the evolution of generalized scientific knowledge, the methods he proposed for improving the humanities and social sciences.
Formation and Realization of Environmental (Ecological) Diplomacy: Possible Ways and Approaches
Authors: Alimov A. A.
Published: April 2024

The article covers theoretical and practical approaches and methods of resolving global socio-environmental (ecological) problem which is considered by the world scientific society to be one of the most complicated, dangerous for all of the human’s community on the Earth and, at the same time, as the most sophisticated to be resolved. Academic publications of Russian and foreign scientists and specialist in this aspect of modern global problems were used and analyzed. Using socio-ecological (socio-environmental) approach, an attempt to propose author’s own understanding of “Ecological (environmental) Diplomacy” was made. The article is provided with documents which were poorly used in scientific literature, as well as special academic books and articles. Important explanations concerning poorly known concepts are also provided.
The Influence of Islamic Leadership and Organizational Culture on Lecturer Satisfaction and Performance Alkhairaat Palu University
Authors: Aldjufri Alwy , Basalamah Salim , Yunus Abd. Rahim , Bunyamin Andi
Published: April 2024

Objectives: The aim of this research is twofold. Firstly, it seeks to analyze the influence of Islamic leadership and organizational culture on the job satisfaction and performance of lecturers at Alkhairaat University, Palu. Secondly, it aims to examine the impact of Islamic leadership and organizational culture on satisfaction and performance through job satisfaction.
 
Methods: This verification research employs a quantitative approach to analyze the influence of Islamic leadership variables and organizational culture variables on job satisfaction and performance of lecturers at Alkhairaat University, Palu.
 
Results: The results of this research reveal that Islamic leadership significantly affects the job satisfaction of lecturers at Alkhairaat University, Palu. Additionally, Islamic leadership has a significant effect on lecturer performance through job satisfaction, although it does not directly impact performance. This finding suggests that the influence of Islamic leadership on performance is mediated by job satisfaction. Organizational culture variables, on the other hand, significantly affect both job satisfaction and performance of lecturers at Alkhairaat University, Palu. Furthermore, organizational culture influences performance through satisfaction. Job satisfaction itself is found to significantly affect the performance of lecturers at Alkhairaat University, Palu.
 
Conclusion: In conclusion, this research highlights the significant influence of Islamic leadership and organizational culture on the job satisfaction and performance of lecturers at Alkhairaat University, Palu. While Islamic leadership directly impacts job satisfaction and indirectly affects performance through satisfaction, organizational culture directly influences both job satisfaction and performance. These findings underscore the importance of fostering positive Islamic leadership and a conducive organizational culture in enhancing the satisfaction and performance of lecturers in an Islamic-based institution like Alkhairaat University.
Exploring the Forbidden Forest Haze: An Ecocritical Analysis of Environmental Themes in the Short Story “Tragedi Asap”
Authors: Juanda  , Mohammad Nhelbourne K. , Polii Intama Jemy , Purba Baharuddin , Mardiningsih  , Afandi Iswan
Published: April 2024

Purpose: This study aims to explore the phenomenon of the forbidden forest haze in the short story Tragedi Asap by Gigih Suroso.
 
Method: This study uses a qualitative method. Data are presented descriptively by using Greg Garrard's ecocritical approach. The research data is in the form of words, phrases, clauses, and sentences in short stories. The data source is from the short story Tragedi Asap which was published by Analisa Newspaper. Data analysis using software Nvivo 12 and reseacher was carried out using interactive and interpretive model analysis techniques consisting of data condensation, data presentation, and concluding/verification.
 
Result and Conclusion: The findings research, there are six aspects presented in the short story, namely pollution, wilderness, apocalypse, dwelling, animals, and earth. Environmental education found is protecting nature, disaster mitigation, and preserving nature as a mandate from God. This short story also features an arcadia construction in the form of a prohibition on the transfer of forest land because it is considered holy and sacred.
 
Implication of the research: The study contributes to public policy by providing an ecocritical analysis of the environmental themes within the short story 'Tragedi Asap'. It sheds light on the portrayal of the natural environment and its ecological implications, offering a nuanced understanding of how literature intersects with environmental issues. This research adds to the broader discourse on environmental literature and its socio-political implications.
 
Originality/value: The research novelty lies in the application of ecocritical analysis to the specific cultural and environmental context depicted in the short story 'Tragedi Asap', offering a unique perspective on the intersection of literature, society, and ecological concerns in a particular cultural setting.
Commentary: Visiting Nurses’ Knowledge, Attitudes, and Beliefs Regarding Telehealth to Promote Medication Compliance in the Older Adult Population: A Qualitative Study
Authors:   Seton Hall University, Renee Logan Diane
Published: April 2024

As a Visiting Nurse working with the older adult population for the past 27yrs, I fully appreciate the use of Telehealth technology in the home care setting to assist with medication reconciliation, since nurses in the home health field are frequently unable to make desired visits based on financial restraints, limited nursing staff and the Covid pandemic that occurred during the above-mentioned study.
Discovering the Value of Novelty: Reconceptualising the Measurement of Novel Experience Preference
Authors:   Dublin City University, Tsabary Canaan
Published: April 2024

This paper addresses the intricate interplay between routine and novelty in the well-being of older adults, challenging the dichotomy often imposed on these concepts. Existing literature highlights the beneficial outcomes associated with both routine and novel experiences for older adults yet fails to provide a comprehensive and contemporary measure of novel experience preference.
The role of lactate dehydrogenase of the pleural liquid in the cytopathological diagnosis
Authors:   Pathology Laboratory, Clinical Hospital “Prof. Dr. Th. Burghele “, Bucharest, Romania, TURCU ELENA ,   SC. OncoTeam Diagnostic SRL, Bucharest, Romania, ARDELEANU CARMEN ,   SC. OncoTeam Diagnostic SRL, Bucharest, Romania, MIHAESCU GRIGORE ,   University of Bucharest, Faculty of Biology, Bucharest, Romania
Published: April 2024

Elevated serum or pleural fluid lactate dehydrogenase (LDH)enzyme levels can be associated with various conditions, including neoplasia, reticuloendothelial tumors, and leukemia. These conditions can lead to cell damage or death, causing LDH to be released into the bloodstream and pleural fluid. An increase in LDH levels may prompt further investigation into the underlying cause, which could include malignancies or other diseases. Elevated LDH levels in pleural fluid are often associated with certain conditions, and our study seeks to establish a quantitative assessment of LDH in conjunction with cytopathological examination for diagnostic purposes. We show here that the presence of abnormal or malignant cells in pleural fluid, as indicated by positive cytopathological results, can be concerning and often necessitates further evaluation. Elevated LDH levels provide biochemical evidence that supports the cytopathological findings, strengthening the case for a potential underlying disease or condition.
PENYULUHAN KEPADA APARAT KANTOR KELURAHAN TENTANG CARA MENGENALI WILAYAH KERJANYA DENGAN MENGGUNAKAN PETA
Authors: Benyamin Benny , Dr. Ir. Hanny W. Wiranegara, M.T  , Marselinus N. Luru, S.T, M.Si  , Reza Fauzi, S.T, M.Ars
Published: April 2024

Instansi pemerintah mulai dari pemerintah sampai ke pemerintah daerah dengan perangkat-perangkat dibawahnya berkewajiban memberikan pelayanan kepada masyarakat (pelayanan publik). Pemerintah harus memastikan bahwa pelayanan publik dilaksanakan dengan baik. Kelurahan adalah unit terkecil instansi pemerintah kota yang kegiatan sehari-harinya berhubungan lansung dengan masyarakat setempat. Untuk menjalankan tugas pelayanan publik ini, aparat kelurahan harus mengenali dengan baik kondisi wilayah dan masyarakat di wilayah kerjanya. Pengenalan wilayah dapat dilakukan dengan mengamati langsung ke lapangan dan juga secara tidak langsung melalui peta. Idealnya pengenalan wilayah ini dilakukan dengan kedua cara tersebut. Pemahaman wilayah oleh aparat kantor kelurahan masih perlu ditingkatkan dan juga harus selalu menyesuaikan dengan perubahan-perubahan berbagai aspek di wilayahnya. Salah satu acara yang paling efektif dan efisien dalam pengenalan wilayah adalah dengan menggunakan peta. Kegiatan Pengabdian kepada Masyarakat dengan judul “Penyuluhan kepada Aparat Kantor Kelurahan Tajur Kota Bogor tentang Cara Mengenali Wilayah Kerjanya dengan Menggunakan Peta” ini merupakan upaya kerjasama antara Program Studi Perencanaan Wilayah dan Kota Universitas Trisakti dengan Dinas Pekerjaan Umum dan Penataan Ruang (PUPR) Kota Bogor untuk memberdayakan aparat Kelurahan Tajur Kota Bogor. Adapun pokok-pokok materi penyuluhan tersebut menyangkut: 1) penjelasan tentang fungsi peta, 2) pemaparan tentang peta-peta tematik kelurahan skala 1 : 5.000, dan 3) Penyantuman pada peta dasar (plotting) berbagai fasilitas umum dan fasilitas sosial yang ada di kelurahan Tajur. Hasil plotting yang berupa peta penyebaran fasilitas umum dan fasilitas sosial di kelurahan Tajur ini akan dapat menjadi arsip bagi Kantor Kelurahan Tajur dan juga dapat digunakan sebagai salah satu masukan kepada Dinas PUPR di dalam penyusunan Rencana Detil Tata Ruang (RDTR) Kecamatan Bogor Timur.
 
Kata kunci: Pelayanan publik, aparat kelurahan, pengenalan wilayah, peta penyebaran fasilitas sosial dan fasiltas umum, RDTR
PELATIHAN PERHITUNGAN HARGA POKOK PENJUALAN USAHA LAUNDRI DI KELURAHAN PONDOK GEDE KECAMATAN JATIWARINGIN KOTA JAKARTA TIMUR
Authors: Karsam  , Solihin  , Devi Kusumawardhani  , Zulmita
Published: April 2024

Tujuan Pengabdian Kepada Masyarakat  ini adalah untuk mengajarkan mitra usaha tentang hal-hal berikut: (1) pemahaman tentang konsep penentuan dan perhitungan harga pokok penjualan entitas; (2) pemahaman tentang pengelompokan dan pengikhtisaran biaya bahan baku, biaya tenaga kerja, dan biaya overhead; (3) pemahaman tentang konsep penyusunan dan pembuatan laporan harga pokok penjualan; (4) pendampingan prosedur klasifikasi atau pengelompokan transaksi, membuat catatan kas, membuat jurnal transaksi, posting ke buku besar, dan penyusunan laporan harga pokok penjualan; dan (5) kegiatan Pengabdian Masyarakat ini memanfaatkan penyuluhan, pelatihan, dan pendampingan melalui penyampaian presentasi materi oleh tim pengabdian masyarakat. Melalui aplikasi Zoom, serta diskusi dengan peserta yang dipandu oleh moderator.
Sangat penting bagi pelaku Usaha Mikro Kecil dan Menengah  untuk menerapkan hasil untuk memahami lingkungan persaingan yang dihadapi. Ini terutama berlaku untuk pengambilan keputusan dalam upaya keberlanjutan usahanya. Dalam menentukan harga pokok penjualan peserta pelatihan harus memilah dan mengelompokan biaya-biaya secara akurat dan tepat dan harus menggolongkan ke dalam tiga golongan biaya yaitu biaya bahan baku, biaya tenaga kerja dan biaya pembantu.
Umpan balik dan masukan dilakukan melalui kuesioner yang dilakukan melalui aplikasi formulir yang tersedia melalui Google. Hasil evaluasi pelaksanaan Pengabdian Masyarakat, baik secara langsung maupun melalui kuesioner, menunjukkan bahwa peserta puas dengan kegiatan pelatihan ini. Tujuan Pengabdian Masyarakat ini bisa tercapai karena peserta mendapatkan manfaat berupa pengetahuan, pemahaman, dan keahlian dalam menghitung harga pokok penjualan serta mengambil keputusan untuk menaikan harga jual agar memperoleh keuntungan yang ditargetkan.
Terapia centrada en el sentido en pacientes oncológicos: una revisión sistemática
Authors:   Universidad Europea de Madrid (España), González-Bernárdez Nerea , González-César Marta ,   Universidad Europea de Madrid (España), Lores-Moreno Víctor ,   Universidad Europea de Madrid (España), Moriconi Valeria ,   Universidad Europea de Madrid (España), González-Moreno Jesús ,   Universidad Internacional de Valencia (España), Cantero-García María ,   Unviersidad a distancia de Madrid (España)
Published: April 2024

Introduction: The need of palliative care patients to address the spiritual and meaning issues in their lives that may arise at the near prospect of death led to the design of Meaning-Centered Psychotherapy (PCS) or Meaning-Centered Psychotherapy (MCP). Objective: The aim of this systematic review is to deepen the knowledge of Meaning-Centered Psychotherapy (PCS) and its intervention in the palliative care setting, thus learning about the psychological effects that may occur in patients with advanced cancer. Results: The main variables where there was a greater improvement by applying PCS were “spiritual well-being,” followed by “desire for accelerated death,” as well as an increase in “quality of life,” and a decrease in the symptoms of “anxiety,” “depression” and “hopelessness.” Conclusion: The results show the need for specific action protocols with proven efficacy such as Meaning-Centered Therapy.
Parámetros meteorológicos y su relación con el dolor. Revisión sistemática
Authors:   Universidad de La Laguna (España), Abad Mesa Texenery , Cervero García María Luz ,   Universidad de La Laguna (España), González Pérez Josmarlin ,   Universidad de La Laguna (España), Hernández-Xumet Juan-Elicio ,   Universidad de La Laguna (España)
Published: April 2024

Introduction: The association between variations in pain intensity and weather changes is present in physiotherapy clinical practice. This review aims to determine the current knowledge regarding the interaction between pain and climate. Methods: A systematic search of 4 databases (PEDro, Scopus, MEDLINE and CINAHL) and the PubMed search engine was performed to identify studies conducted on this topic in the last thirteen years. Results: A total of 1082 articles were found, which were reduced to 17 when the search criteria were applied: two of them dealt with acute pain, fourteen with chronic pain, and one with pain without previous pathology. Only two reviews were included: one narrative and one systematic. They were evaluated using two rating scales: PEDro and an expert scale developed by the authors. Conclusions: The study of the pain-climate association is complicated. Concerning chronic pain, there is an association; however, it does not seem clinically significant, and very few pathologies are considered to cause it, so the number of studies would need to be increased to reach a clear conclusion.
Absentismo laboral. Una mirada a los accidentes de trabajo en España durante el periodo 2014-2022
Authors: Lázaro Leal Sara , Arroyo López Carmen ,   Universidad de La Laguna (España), Leal Felipe María de los Ángeles ,   Universidad de La Laguna (España), García Hernández Alfonso Miguel ,   Universidad de La Laguna (España)
Published: April 2024

To know the evolution of the occupational accident rate in our country in the period 2014- 2022, and its impact on absenteeism due to temporary incapacity (TI). Conclusions: The impact of the covid-19 pandemic on the results of total absenteeism due to occupational accidents with sick leave is significant. This increase is mainly due to the increase in work accidents with sick leave in the group of Health Activities and in the group of Health Professionals, since accidents in itinere do not show significant increases in the years of pandemic compared to previous years. The number of sick days in health activities and in the group of health professionals increased significantly in the pandemic period. The group of professionals in the rest of the economic activities behaves differently in sick leave days than the rest of the groups with increases and decreases throughout the years. (Remember that we were in a period of confinement in a state of alarm: between March 14 and June 21, 2020).
Más allá de los límites: el ejercicio terapéutico como herramienta clave en la lesión medular. Protocolo de trabajo
Authors:   Universidad de La Laguna (España), Negrín Ventura Samuel , Godoy Luján Silvia ,   Universidad de La Laguna (España), Méndez Sánchez Roberto ,   Universidad de Salamanca (España), González Pérez Josmarlin ,   Universidad de La Laguna (España), Hernández Xumet Juan Elicio ,   Universidad de La Laguna (España)
Published: April 2024

Introduction: People with spinal cord injury (SCI) suffer from many comorbidities due to a sedentary lifestyle. Current scientific evidence suggests that increasing physical activity levels in these people would reduce morbidity and improve their quality of life and independence. However, current guidelines suggest exercise intensities that are considered inadequate compared to a population without pathology. Objectives: To develop a high-intensity exercise programme to improve functionality and reduce specific risk factors in people with spinal cord injury. Methods: An exercise programme for chronic SCI is presented that requires 2 groups (experimental and control). The experimental group will perform a programme of Strength, Aerobic and Trunk Stabilising Muscle Control, 3 times a week for 6 months, while the control group will receive educational talks on the importance of physical activity and healthy lifestyle habits.
“VALHA-ME NOSSA SENHORA, MÃE DE DEUS DE NAZARÉ”:
Authors: Silva dos Santos Thifane de Cássia , Cunha Ferreira Israel , Dos Santos Siqueira Thiago
Published: April 2024

O presente trabalho busca analisar a atuação da Compadecida no julgamento existente na Obra de Ariano Suassuna denominada de “Auto da Compadecida”, a partir do Instituto da Mediação. Para isso, inicialmente, analisa-se sobre a atuação do Estado frente aos Conflitos existentes em uma sociedade, atrelando às situações vividas pelos personagens da peça. Em seguida, discorreu-se sobre o Julgamento como introdução ao Sistema Multiportas para a resolução de conflitos e a percepção do Acesso à Justiça. Logo após, discorreu-se sobre as possibilidades dos institutos autocompositivos e heterocompositivos como a Arbitragem, Negociação e a Conciliação e Mediação. Por fim, debruçou-se sobre a Mediação associando-a aos fatos narrados pelo autor quanto ao julgamento dos personagens e a atuação da mediadora A Compadecida, analisando sobre a ótica da mediação, função e características e o protagonismo das partes na tomada de posição frente aos conflitos. Para esse fim, aplicou-se as metodologias: pesquisa qualitativa, cuja base está através de referências bibliográficas; verificando sua adequação ao trabalho; As comparações com o posicionamento da personagem A Compadecida, observando sua similitude, sob a ótica jurídica, com o Instituto de Mediação devido o seguimento aos princípios e condutas esperadas e adequadas diante de um conflito.
ENFRENTAMENTO DA COVID-19 E A VIOLAÇÃO DOS DIREITOS DOS DETENTOS DURANTE A PANDEMIA.
Authors: Aquino Lemos Luís Carlos de , Dos Santos Siqueira Thiago
Published: April 2024

O presente trabalho se origina da pretensão de se estabelecer uma análise reflexiva sobre o enfrentamento da pandemia e a violação dos direitos dos detentos. A pandemia de covid-19, foi um evento global de saúde que começou em dezembro de 2019 na cidade de Wuhan, na província de Hubei, na China. A infração dos direitos dos detentos durante a pandemia da covid-19 foi uma preocupação significativa em muitos países, incluindo o Brasil. A pandemia também trouxe desafios significativos para a administração penitenciária em muitos países, incluindo questões relacionadas aos direitos dos detentos. A superlotação das prisões, a falta de acesso a cuidados médicos adequados e a propagação do vírus em ambientes carcerários criou condições propícias à violação dos direitos humanos dos presos. A situação das detenções durante a pandemia varia de um país para outro e, em alguns lugares, foram tomadas medidas para mitigar essas infrações aos direitos das detenções. Os direitos dos detentos são um conjunto de direitos fundamentais garantidos às pessoas que estão sob custódia do Estado, ou seja, aqueles que estão presos em estabelecimentos prisionais, centros de detenção ou locais de reclusão. A representação de pessoas negras no sistema prisional é uma realidade gritante. Essa disparidade reflete não apenas desigualdades sociais e econômicas históricas, mas também um sistema de justiça criminal que, em muitos casos, não trata todos os cidadãos com igualdade. A proteção desses direitos é fundamental para garantir que os detentos tratados sejam com dignidade e respeito, mesmo durante o cumprimento de suas penas.
DIFICULDADES E OBSTÁCULOS NO PROCESSO DE ADOÇÃO NO BRASIL
Authors: Orrico Ivana , Martins Sheila Cunha , Siqueira Thiago dos Santos
Published: April 2024

Neste trabalho, fora discutido o sistema de adoção no Brasil, destacando seus principais desafios e obstáculos. Serão analisados os dados do Sistema Nacional de Adoção e Acolhimento, revelando uma discrepância entre o número de candidatos à adoção e o número de crianças disponíveis. Além disso, serão abordadas questões relacionadas às preferências dos adotantes, o preconceito racial, a adoção de crianças com necessidades especiais e grupos de irmãos. Propõe-se estratégias para superar tais complexidades, como campanhas de conscientização, educação sobre adoção em todas as idades e promoção da diversidade cultural. Face ao exposto, a problemática do trabalho está evidenciada na dificuldade enfrentada pelos candidatos a adoção no País. O acompanhamento interprofissional durante o processo de adoção é enfatizado. Este estudo destaca a necessidade contínua de reformas no sistema de adoção, priorizando o bem-estar das crianças em busca de um lar permanente.
MOROSIDADE DO JUDICIÁRIO E NEGATIVA DO ESTADO BRASILEIRO PARA ATENDER AS DEMANDAS INDISPENSÁVEIS PARA CRIANÇA COM TRANSTORNO DO ESPECTRO AUTISMO NA ÚLTIMA Dé
Authors: Pereira de Souza Isabelli , Cunha Martons Sheila , Dos Santos Siqueira Thiago
Published: April 2024

O presente artigo trata-se de uma pesquisa para compreender qual o motivo da morosidade do Judiciário e negativa do Estado Brasileiro para atender as demandas indispensáveis para crianças com Transtorno do Espectro Autismo na última década. Assim, em primeiro momento será definido o que é direito a saúde, demonstrando as diversas modificações que foram realizadas em seu conceito até chegar no direito à saúde que temos atualmente. Após isso, será analisado qual o papel do Estado como responsável por zelar pela saúde do povo, apesar de algumas dificuldades encontradas, como as questões orçamentarias, o cidadão tem total direitos, mas como foi observado esse direito pode sofrer limitações. São justamente essas limitações, ou imposições, que serão responsáveis pela Judicialização da Saúde e também da política. Ainda, será identificado quais as terapias necessárias para a criança com TEA, apesar desse transtorno não ter uma cura, as terapias podem levar essa criança a uma mudança considerável no quadro de suas limitações. Por fim, será pesquisado se a algum perigo da demora no desenvolvimento da criança com TEA, já que quanto mais cedo iniciar a terapias, melhoras mais visíveis no desenvolvimento da criança será evidenciado.
Perioral dermatitis: nuances of the clinical picture and therapy in different age periods
Authors: Letyaeva Olga I. , Trapeznikova Tatyana V. , Gubina Valeria O.
Published: April 2024

Perioral dermatitis is a common dermatosis that predominantly affects women aged 25–40 but is also observed in children and adolescents. The distinct localization of this condition in the perioral, perinasal, and periocular zones contributes to apparent psycho-emotional distress, markedly impairing patients’ quality of life. Perturbations in the skin biotope, local immune dysregulation, and topical glucocorticosteroid use are among the primary etiological factors. Effective management involves addressing causative factors, discontinuation of topical steroids, adopting gentle skincare practices, and employing localized treatments like metronidazole, pimcrolimus, and activated zinc pyrithione. Maintenance therapy may be warranted in select cases. The purpose of this work is to review the current literature on the problem and to present original clinical observations concerning the utilization of activated zinc pyrithione in treating patients with this condition. The article presents the results of the use of topical activated zinc pyrithione in patients spanning various age groups and exhibiting diverse degrees of perioral dermatitis severity. Significant clinical evidence substantiates the remarkable efficacy and safety profile of activated zinc pyrithione in managing perioral dermatitis, both as a standalone therapeutic modality and as an integral component of combination therapy. The use of activated zinc pyrithione in the treatment of perioral dermatitis emerges as an efficacious and secure approach for treating mild to moderate forms of the condition.
Darier–White’s follicular dyskeratosis. Experience of successful therapy
Authors: Drozhdina Marianna B. , Bobro Varvara A. , Derpalyuk Elena N.
Published: April 2024

Darier–White’s follicular dyskeratosis is an autosomal dominant hereditary dermatosis, which is based on pathological keratinization due to impaired adhesion between keratinocytes, manifested mainly in the form of hyperkeratotic follicular papules on seborrheic areas of the skin. Therapy of rare genodermatosis still presents difficulties in the tactics of choosing a treatment method for each individual patient. Currently, there are no regulated methods of treating this disease. Isotretinoin is a well-studied drug, the profile points of application of which are moderate and severe forms of acne, rosacea, but recently indications for the use of isotretinoin have been increasing. In this article presents a clinical case of Darier–White’s follicular dyskeratosis and demonstrates the successful experience of therapy of rare genodermatosis with isotretinoin.
Stability Indicating Technique and Validation for Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate by UPLC
Authors: Nagamalleswari Gampa , Shankar MS Uma
Published: April 2024

Objective: To simultaneously estimate lamivudine, tenofovir, and dolutegravir in substance and tablet dosage form,” a technologically sophisticated approach was developed for ultra-performance liquid chromatography (UPLC) stability indicating that is modest, accurate, and specific. Methods: We were able to isolate each of the three active components using a state-of-the-art stability-indicating approach. Waters X-Bridge C8 column, 100 x 3.0 mm, 3.5 μm, 0.5 mL/min flow rate, and monitoring at 260 nm were used for the chromatographic behavior, which was shown by a mobile phase consisting of acetonitrile and 0.1% formic acid in an 80:20 ratio. Results: A mean retention time of 0.879 minutes was recorded for lamivudine, 1.571 minutes for tenofovir, and 0.607 minutes for dolutegravir. “The degrees of linearity for lamivudine, tenofovir, and dolutegravir were determined to be 20 to 120 μg/mL, 20 to 120 μg/mL, and 3.4 to 20.4 μg/mL, respectively. Conclusion: Combination tablet dosage forms of lamivudine, tenofovir, and dolutegravir were accurately and reliably estimated using the suggested technique, which underwent validation in terms of linearity, range, accuracy, precision, specificity, and robustness. Stability tests were also conducted.
Taguchi Design for Development of Lipid-Polymer Effervescent Floating Tablets for Metformin Prolonged Release
Authors: P García-Guzmán , L Schifter-Aceves , L Ortega-Almanza , P Romero-Canto
Published: April 2024

TFloating drug delivery systems (FDDS) formulated with hydrophilic polymers and effervescent agents are a promising gastro retentive tool for prolonged drug release, especially with drug with low bioavailability and low solubility. Lately, it has been reported that the combination of lipids with hydrophilic polymers in the development of blends or composite hybrid materials may bring together the properties of individual components. This study proposed four formulations of effervescent lipid-polymer FDDS through a Taguchi experimental design for metformin’s prolonged release. Tablets were obtained by wet granulation, and the effect of HPMC, Compritol®, and sodium bicarbonate was studied. All formulations were evaluated with pharmacotechnical and biopharmaceutical properties such as in-vitro drug delivery, flotation, swelling, erosion and release kinetics. Effervescent lipid-polymer FDDS were obtained with prologued release until 24 hours. Formulation F1 meets the acceptance criteria of USP extended delivery. Compritol®, combined with HPMC and sodium bicarbonate, impacted release behavior and buoyancy properties. Formulations with high amounts of HPMC and Compritol® were found to have the lowest release rates and followed the Peppas-Sahlin kinetic model. Successful preparation of effervescent lipid-polymer was achieved and evaluated through a Taguchi experimental design, expected to result in prologued release and better therapeutic behavior
Assessment of Inter-Individual Pharmacokinetic Variability of Voriconazole Based on Bile Salt Disparities using POP-PK Modeling
Authors: Sharma Priya , Naved Tanveer , Thakkar Arti R
Published: April 2024

Background and Objectives: Voriconazole is a powerful biopharmaceutics classification system (BCS) class II antifungal agent with vast inter-individual pharmacokinetic variability. Bile salts have recently emerged as potential contributors to such variations. Based on population PK modeling and in-vitro biorelevant dissolution investigations, the current study intends to evaluate the inter-individual variability of voriconazole in pediatrics. Methods: All models were developed using PK-Sim software. A simulated population consisting of 100 pediatric individuals was established following the baseline model development. Further, experimentally obtained in-vitro dissolution data of voriconazole based on the bile salt differences representing different pediatric age groups were incorporated into a qualified pediatric model. Simulated plasma concentration-time profiles were then evaluated by comparing model-predicted parameters with that of the baseline model to draw inferences. Result: Each model was created and validated successfully. The pediatric subjects were shown to have larger inter-individual variability than adult subjects. Additionally, simulations based on individual parameter estimations from the final model showed that after administering a 4 mg/kg peroral dose of voriconazole, the anticipated Cmax values of the adult model were within a two-fold range compared to that of the pediatric model. However, upon comparison, the model-predicted population pk profiles of children, infants, and neonates showed minimal variations in the Cmax values. Conclusion: In pediatrics, voriconazole inter-individual variability was significantly influenced by the concentration of gut bile salts. Furthermore, the present research can be carried forward along with population PK modeling and sufficient clinical data for dose recommendations in special populations as well as in diseased conditions.
Evaluating the Efficacy of Tetracycline Local Drug Delivery in Managing Oral Lesions Caused by Pathogens: A Comparative Study
Authors: Ahmed Hina , Gupta Shekhar , Gupta Bharti , Patil Dipooja
Published: April 2024

Background: Oral lesions caused by pathogens represent a significant clinical challenge, necessitating effective management strategies. Due to its antimicrobial properties, tetracycline local drug delivery has shown promise in combating such lesions. This study aims to evaluate the efficacy of tetracycline local drug delivery compared to conventional treatments in managing oral lesions caused by pathogens. Materials and Methods: A comparative study was conducted involving 100 patients diagnosed with oral lesions attributable to pathogenic infections. Patients were randomly assigned to either the tetracycline local drug delivery group or the conventional treatment group. The tetracycline group received locally administered tetracycline, while the conventional group received standard treatments such as antiseptic mouthwashes or topical corticosteroids. Lesion size, pain scores, and microbial load were assessed at baseline and after four weeks of treatment. Results: In the tetracycline local drug delivery group, the mean reduction in lesion size was 50%, compared to 30% in the conventional treatment group (p < 0.05). Pain scores decreased significantly in both groups, with a greater reduction observed in the tetracycline group (p < 0.01). Microbial load showed a significant decrease in the tetracycline group compared to the conventional group (p < 0.001). Conclusion: Tetracycline local drug delivery demonstrates superior efficacy in managing oral lesions caused by pathogens compared to conventional treatments. It significantly reduces lesion size, pain scores, and microbial load. Incorporating tetracycline local drug delivery into clinical practice could offer a more effective approach to treating such oral lesions.
New Stability Indicating HPLC Method for Related Substances in Dapagliflozin
Authors: Chavan Bhagwat , Birajdar Avinash , Bhusnar Hanumant , Yadav Jayadeep , Badadhe Sandip
Published: April 2024

The requirements established by the International Council for Harmonization (ICH) for the measurement of dapagliflozin from tablets were satisfied by the development and successful implementation of an reversed-phase high performance liquid chromatography (RP-HPLC) technique that is characterized by its speed, precision, and accuracy. In order to separate the samples, an isocratic mode was used on a Princeton C18 column that was operating at a flow rate of 1-mL per minute. The phase was composed of acetonitrile and 0.1% triethylamine in a volume-to-volume ratio of 50:50, with a pH of 5.0 and a detection wavelength of 224 nm. 5.163 minutes was the retention time that was determined to be best under the circumstances of the chromatographic analysis. Based on the correlation value of 0.999, it can be concluded that the procedure adhered to Beer-Lambert’s law within the measurement range of 10 to 70 μg/mL. The findings not only verified the claim that was made on the label, but they also validated the mean percent drug concentration that was specified for the commercial tablet formulation, which was 100.57%. Following the completion of an investigation, it was discovered that the approaches that were proposed have sufficient proportions of precision measurements, robustness, accuracy, range, and linearity. As part of the technique for stress testing, a number of criteria were evaluated and evaluated overall. The elements that were considered to be among these were light, humidity, temperature, oxidation, and pH (acid/base).
Unraveling the Therapeutic Prospects of Solid Lipid Nanoparticles for the Treatment of Parasitic Diseases
Authors: Singh Harman , Singh Manveer , Singh Navdeep , Jain Himanshu , Goel Honey , Chawla Viney
Published: April 2024

Parasites induce a spectrum of illnesses, ranging from mild to severe, often causing significant global outbreaks. Existing antiparasitic drugs exhibit toxicity and notable side effects. Nanocarriers offer a promising solution by mitigating these issues through reduced side effects, enhanced target delivery, and additionally regulated prolonged active ingredient release. Solid lipid nanoparticles (SLNs), a subset of lipid nanoparticles (LNPs), have gained prominence for their favorable attributes. SLNs present themselves as a feasible option among colloidal carriers, offering an optimal release rate, stability, and precise target delivery. Their potential to deliver natural antiparasitic products is particularly noteworthy. Recent advancements in utilizing nanoparticles to enhance SLN stability and loading capacity are also explored in this review. The narrative encompasses SLN development, preparation methods, characterization, and the incorporation of drugs for combating parasitic diseases, offering insights into the evolving landscape of antiprotozoal SLN-saturated medications
Current Insights of Nano Suspension Drug Delivery System: A Patent Review
Authors: Jeslin D , Masilamani K
Published: April 2024

Unfortunately, water-solvency continues to be a usual characteristic of medication newcomers in medicine improvement pipelines today. Different cycles have been established to improve the solvency, disintegrating rate, and bioavailability associated with these dynamic fixes having a place utilizing the biopharmaceutics classification system (BCS) II through IV orders. Since the mid-2000s, nanosuspension, nanocrystal delivery, and nebulous strong scatterings have been more established approaches to overcome the obstructions of ineffective water solvent pharmaceuticals in food and drug administration (FDA) accessible goods. This work supplies a refreshed examination of nanosuspension and dissimilar strong scattering methods, particularly for orally conveyed medications. Moreover, solvency is a vital variable for medication adequacy, autonomously of the course of development. Ineffectively solvent drugs are many times difficult assignments for developers within the sector. Customary methods to improve solvency are of little significance, specifically when the pharmaceuticals are ineffectively liquid all the while they’re watery as well as non-fluid mediums. Nanosuspension technology can be employed to enhance the potency and solubility with insoluble substances medicines. Nanosuspension possesses dual-phase structures made up of precise medication particles scattered throughout a liquid medium kept in check with surfactants. Those strategies generally straightforward plan offer advantages compared to alternative methods. Various methods, comprising wet manufacturing, regions assembling, emulsifying, evaporating the solvent, and releasing simple liquid methods, are employed when making nanosuspension. Subsequently enjoys convenience conveyance via diverse courses, comprising oral, parenteral, aspiratory even visual courses. The current proposal plan provide the ongoing strategies employed to get ready small suspensions, including their application in medication conveyance
Cutaneous adverse drug reactions in children with a focus on hypersensitivity to systemic drugs: A narrative review
Authors: Chiriac Anca E. , Pinteala Tudor , Chiriac Anca , Wollina Uwe
Published: April 2024

Drug hypersensitivity in children is rare compared to adults. Children more frequently develop an infection-associated exanthema. Nevertheless, about 95% of children with drug hypersensitivity present with mucocutaneous involvement. Early recognition of typical clinical symptoms is important to reduce morbidity and mortality. We review relevant type I and type IV disorders of drug hypersensitivity in children and discuss their differential diagnoses and treatment.
Evacuable Small-Sized Direct Joule-Heated Melter Designed by PA Mayak to Immobilize LRW from SNF Reprocessing into Borosilicate Glass Developed and Tested as Part of a New HLW Vitrification Complex
Authors:   FSUE “PА “Mayak”, Remizov M. B. , Melentyev A. B. ,   FSUE “PА “Mayak”, Shaidullin S. M. ,   FSUE “PА “Mayak”, Verbitsky K. V. ,   FSUE “PА “Mayak”, Kozlov P. V. ,   FSUE “PА “Mayak”, Bendasov D. I. ,   FSUE “PА “Mayak”
Published: April 2024

The article describes the State of Art in HLW vitrifi ation at the PA Mayak’s radiochemical production facility. It presents some conceptual and engineering designs that may further advance the vitrifi ation technology at the enterprise considering various types of liquid HLW. The article discusses the key differences between the promising evacuable small-sized melter and the units previously operated at the enterprise. It overviews its evolvement stages and the results of tests run at PA Mayak in 2018—2020 on the prototypes of evacuable small-sized direct Joule-heated melters designed for borosilicate glass melting. The paper overviews a wide range of the implemented studies and the melters’ operational experience. It focuses more specifi ally on the third improved prototype of an evacuable small-sized melter with its designs developed by PA Mayak in 2022 based on the previously tested prototypes.
On Construction of Disposal Facilities for Radioactive Waste in European Part of Russia
Authors:   Nuclear Safety Institute of the Russian Academy of Sciences, Linge I. I. , Barinov A. S. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: April 2024

The article dwells on feasibility and probability of designing and constructing disposal facilities for low and intermediate level waste in European part of the Russian Federation. Clay and mudstone deposits are considered as host rocks with regards of their widespread. Main reasons preventing the construction of disposal facilities being analyzed and the social reason is stated as a principal one.
Transport Process Modeling Assuming Chemical Interactions in the GeRa Software
Authors:   Nuclear Safety Institute of the Russian Academy of Sciences, Kapyrin I. V. , Boldyrev K. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: April 2024

The paper considers a transport model with geochemical couplings implemented in the GeRa software. It evaluates the scope of application typical for such models focused on the safety assessment of nuclear facilities. The paper presents a few typical case studies to demonstrate the accountability of different chemical processes: ion exchange, surface complexation, dissolution and mineral phase precipitation. It overviews some typical radionuclide transport problems with an account taken of sorption, as well as the one of concrete decalcification.
Model Estimating the Brine Volume Inflowing a RW Storage Facility in Halites Considering their Microstructure
Authors:   Nuclear Safety Institute of the Russian Academy of Sciences, Korchagina O. O. , Matveev L. V. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: April 2024

The paper proposes a model estimating the volume of brine infl w into a repository with heat generating radioactive waste prompted by liquid inclusion transport in halites. The model takes into account the polycrystalline structure of natural halites and two brin fl w mechanisms associated with it: 1) the one prompted by thermomigration of intragrain inclusions and 2) the one prompted by brine transfer along the intergranular channels. Movement of intragrain inclusions is explained by salt transport occurring inside the inclusions, which in turn is driven by additional salt dissolution at the hot wall of an inclusion and its condensation on the cold one. Strong coupling between the intergranular inclusions and the grain boundaries provides the intergranular channel stability. The paper describes in detail both mechanisms and provides the formulas for inclusion transport rate calculations. It estimates the brine infl w for spherical and cylindrical repositories based on parameters taken from relevant literature sources. The study shows that halite microstructure and its accounting are crucial for the calculated brine infl w that can amount to tenths of the repository volume.
CO2-to-methanol electroconversion on a molecular cobalt catalyst facilitated by acidic cations
Authors: Yu Sunmoon , Yamauchi Hiroki , Wang Shuo , Aggarwal Abhishek , Kim Junghwa , Huang Botao , Xu Hongbin , Zheng Daniel , Wang Xiao , Iriawan Haldrian , Menga Davide , Shao-Horn Yang
Published: April 2024

The crucial role of electrolyte cations in CO2 electroreduction has received intensive attention. One prevailing theory is that through electrostatic interactions or direct coordination, larger cations such as Cs+ can better stabilize the key intermediate species for CO and multicarbon (C2+) product generation, for example, on silver and copper, respectively. Herein, we show that smaller, more acidic alkali metal cations greatly enhance CO2-to-methanol conversion kinetics (Li+ > Na+ > K+ > Cs+) on an immobilized molecular cobalt catalyst, unlike the trend observed for CO and C2+. Through kinetic isotope effect studies and electrokinetic analyses, we found that hydration shell of a cation serves as a proton donor in the rate-determining protonation step of adsorbed CHO where acidic cations promote the proton-coupled electron transfer. This study reveals the promotional effect of cation solvation environment on CO2 electroreduction beyond the widely acknowledged stabilizing effect of cations.