bluuebunny/crossref_metadata_2025 huggingface dataset:
A numerical critical shear crack model and its application to post‐peak behavior assessment of RC and SFRC beams
Authors: Xiang Dong , Yu Yating , Gao Xiangling
Published: April 2024

In this paper, a numerical critical shear crack model, in which the shear‐flexural coupling effect is considered and the full process of stress and strain is captured, is proposed to evaluate the post‐peak behavior of reinforced concrete (RC) and steel fiber reinforced concrete (SFRC) beams. The shape of critical shear crack is identified by combining the modified compression field theory considering the bridge effect of steel fibers and the section analysis method. Based on the shape of critical shear crack, the shear capacity of beam members is provided by the shear tension zone and the shear compression zone. The shear capacity of the shear tension zone is calculated by the modified compression field theory and that of the shear compression zone is determined by multiaxial strength criterion of concrete. The vertical displacements caused by the flexure deformation and shear deformation are deduced by the moment area method and integration of shear strain. To verify the proposed numerical approach, a test database of 486 RC beams and 313 SFRC beams was established to predict the shear strength, and the force‐displacement relationships of twelve beam members are used to validate the feasibility for full process analysis. The stochastic analysis of beams with different failure modes is conducted via GF‐discrepancy‐based point selection method and probability density evolution method. The limitation between different failure modes is defined according to the degradation percent of shear capacity and it is taken as threshold value of failure domain, and the failure probability analysis indicates that the designed flexure beam member suffered severe degradation of shear capacity, resulting in a significant decline in safety probability.
Local Community Assembly Mechanisms and the Size of Species Pool Jointly Explain the Beta Diversity of Soil Fungi
Authors: Xing Hua , Chen Wuwei , Liu Yu , Cahill James F.
Published: April 2024

Fungi play vital regulatory roles in terrestrial ecosystems. Local community assembly mechanisms, including deterministic and stochastic processes, as well as the size of regional species pools (gamma diversity), typically influence overall soil microbial community beta diversity patterns. However, there is limited evidence supporting their direct and indirect effects on beta diversity of different soil fungal functional groups in forest ecosystems. To address this gap, we collected 1606 soil samples from a 25-ha subtropical forest plot in southern China. Our goal was to determine the direct effects and indirect effects of regional species pools on the beta diversity of soil fungi, specifically arbuscular mycorrhizal (AM), ectomycorrhizal (EcM), plant-pathogenic, and saprotrophic fungi. We quantified the effects of soil properties, mycorrhizal tree abundances, and topographical factors on soil fungal diversity. The beta diversity of plant-pathogenic fungi was predominantly influenced by the size of the species pool. In contrast, the beta diversity of EcM fungi was primarily driven indirectly through community assembly processes. Neither of them had significant effects on the beta diversity of AM and saprotrophic fungi. Our results highlight that the direct and indirect effects of species pools on the beta diversity of soil functional groups of fungi can significantly differ even within a relatively small area. They also demonstrate the independent and combined effects of various factors in regulating the diversities of soil functional groups of fungi. Consequently, it is crucial to study the fungal community not only as a whole but also by considering different functional groups within the community.
Investigating potential supply of ecosystem services in cultural landscapes through efficiency analysis
Authors: Leban Vasja , Zadnik Stirn Lidija , Pezdevšek Malovrh Špela
Published: April 2024

One of the paramount challenges in natural resource management revolves around the delicate equilibrium between the demand for and the supply of diverse Ecosystem Services (ESs) within a cultural landscape. Recognizing the centrality of cultural landscapes to human well-being, the sustainability of these landscapes hinges upon the health and stability of ecosystems that can effectively provide the required ESs. Over the long term, the sustainable supply of ESs is constrained by the potential supply of ESs. Understanding the potential supply of ESs is crucial for averting compromises to the ecosystems within a landscape. This article introduces a novel perspective on evaluating the ESs of a landscape by means of efficiency analysis. Instead of presenting the potential supply of ESs in absolute terms, we offer a comparative analysis of ESs' relative supply to associated management costs. In principle, the efficiency of Landscape Units (LUs) is defined as the ratio of the potential supply of multiple ESs to the costs associated with land use and land cover management. The resultant efficiency maps serve as hot and cold spot maps, revealing efficient ecosystem compositions that yield multiple ESs. This composition reflects management efforts, incorporating various management costs. Forests emerge as pivotal ecosystems in landscapes, delivering the most ESs at the lowest costs. These efficiency maps offer valuable insights for regional planners, enabling them to enhance the supply of ES in inefficient LUs by studying the ecosystem structure and associated costs of the most efficient LUs.
Three-dimensional assessment of upper airway changes associated with mandibular positional deviations following fibula free flap reconstruction
Authors: Schulz Katja Leonie , Matta Ragai , Nobis Christopher-Philipp , Möst Tobias , Kesting Marco , Lutz Rainer
Published: April 2024

Objectives

Fibula free flaps (FFF) are the standard approach to mandibular reconstruction after partial resection, with the goal of restoring aesthetics and masticatory function. The graft position affects both and must be carefully selected. Correlations between sagittal positioning and upper airway anatomy are known from orthognathic surgery. This study aims to evaluate changes in mandibular position and upper airway anatomy after reconstructive surgery with FFF and corresponding correlations.

Materials and methods

Mandibular position after reconstruction was evaluated using three-dimensional datasets of pre- and postoperative computed tomography scans of patients treated between 2020 and 2022. Three-dimensional measurements were performed on both condyles and the symphyseal region. Changes in upper airway volume and minimum cross-sectional area (minCSA) were analysed. Intra-rater reliability was assessed. Correlations between changes in upper airway anatomy and sagittal mandibular position were tested.

Results

The analysis included 35 patients. Intra-rater reliability was good to excellent. Condylar deviations and rotations were mostly rated as small. Changes in symphyseal position were considerably greater. Median airway volume decreased in the oropharynx and hypopharynx. Posterior deviation of the symphysis was associated with a decreasing minCSA in the hypopharynx and vice versa.

Conclusions

The overall accuracy of mandibular reconstructions with FFF is high, but there is room for optimization. The focus of research should be extended from masticatory to respiratory rehabilitation.

Clinical relevance

Effects on respiratory function should be considered prior to graft positioning. The clinical relevance of upper airway changes within the complex rehabilitation of reconstructive surgery patients needs to be further investigated.
An upper bound for the inter-exit time of two jobs in an m-machine flow shop
Authors: Urgo Marcello , Manzini Massimo
Published: April 2024

This paper addresses the class of permutation flow shop scheduling where jobs, after their completion, must be grouped in batches. This is a common scheme in industrial environments, where products undergo multiple process steps in different shops and, when completed, must be transported to customers or the next production step. A new optimisation criterion is used, the inter-exit time, i.e., the difference between the completion times of two jobs. An upper bound is proposed and demonstrated for a general permutation flow shop with m machines.
The Validity of Heart Rate Variability (HRV) in Educational Research and a Synthesis of Recommendations
Authors: Kim Hyun Jin , Park Yuyi , Lee Jihyun
Published: April 2024

This study provides a comprehensive overview of methodological aspects when using heart rate variability (HRV) measures in educational research. Following PRISMA 2020 guidelines, we searched four databases for relevant studies published until March 5, 2024. From the 48 studies reviewed, we extracted data across three analytical categories: (1) area of study interest and participant populations, (2) data collection and analysis methodologies, and (3) the concurrent and predictive validity of HRV measurement for educational research. Study quality was evaluated using QualSyst assessment criteria. Most studies measured stress and enlisted undergraduate students as participants. Data were predominately collected using wearable devices, measuring HRV for durations of less than 30 min, and in varied contexts, including during exams, while learning, and in experiments. The parameters analyzed varied within both time and frequency domains. HRV data had a moderate level of concurrent validity as a measure of stress in an educational context. The concurrent validity of HRV data for measuring attention remains uncertain with insufficient evidence. Limited correlations appeared between stress and performance. The findings, potentials, and limitations of HRV measures are discussed, and synthesized recommendations for educational research using HRV data are provided.
A holistic approach for tourism carrying capacity estimation in sensitive ecological areas
Authors: Skiniti Georgia , Lilli Maria , Skarakis Nikolaos , Tournaki Stavroula , Nikolaidis Nikolaos , Tsoutsos Theocharis
Published: April 2024

Mediterranean ecosystems are in the spotlight of tourism activities, with the local populations trying to make the most of them, while in parallel, the stress signs, such as habitat and biodiversity degradation, increased pollution, or beach erosion, have begun to emerge. Furthermore, this combination of exotic and delicate qualities accompanied by excessive tourist flows leads to the imperative need for sustainable tourism development studies in these areas. In the current study, aiming to develop a new holistic framework for assessing Carrying Capacity in sensitive coastal ecosystems, a combined methodology was created and tested in Balos Lagoon, a Natura 2000 area in Western Crete. The method encompasses calculating different Carrying Capacity indicators, environmental quality measurements, visitors’ perceptions identification, and finally, a multicriteria analysis to capture the stakeholders’ and local community’s viewpoints. The combined methodologies identified vital issues, including overcrowding—Effective Carrying Capacity is exceeded by 1000 people per day during the peak season—tar residue pollution, microplastics, insufficient road infrastructure and excessive car numbers exceeding capacity. Stakeholder involvement was pivotal, prioritizing twelve proposed actions to address those issues. Notably, “frequent beach clean-ups,” targeting visual impacts, emerged as the most critical action, while parking reallocation and setting a maximum daily ferry limit were also highly ranked, promising solutions to alleviate overcrowding issues. The paper offers valuable insights for future research, emphasizing the need for continuous environmental monitoring, implementation of high-priority measures, and economic valuation of natural capital. Ultimately, this research contributes to the literature by presenting a pioneering methodology for holistic assessment and sustainable tourism development in Mediterranean sensitive coastal ecosystems.
Electronic shopping cart abandonment: What do we know and where should we be heading?
Authors: Chopra Ishani Patharia , Jebarajakirthy Charles , Jain Tanu , Maseeh Haroon Iqbal
Published: April 2024

This paper aims to systematically review the literature on electronic shopping cart abandonment (ESCA). It analyzes the development of ESCA literature in terms of publication trends, publication outlets, number of citations, methodologies, and theoretical underpinnings. Furthermore, based on the literature synthesis, this review proposes a conceptual framework integrating the widely used antecedents, mediators, and moderators that influence ESCA. The antecedents include customer attributes and website-related factors while research and comparison mediate the relationship between these antecedents and ESCA. Using lexicometric analysis, this SLR identified key themes studied in ESCA literature over time, including customer decision-making criteria, motives and characteristics, online shopping environment, and website attributes. Further, this SLR suggests future research directions to advance ESCA literature from theoretical, contextual, and methodological perspectives. This SLR also suggests strategies for e-retailers and marketers to overcome ESCA. Overall, this review is a silver line in ESCA literature.
Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review
Authors: Tang Liu , Xu Haifei , Wu Tong , Wu Wenhao , Lu Yuhao , Gu Jijia , Wang Xiaoling , Zhou Mei , Chen Qiuyang , Sun Xuan , Cai Hongzhou
Published: April 2024

Bladder cancer is one of the most frequent malignant tumors of the urinary system. The prevalence of bladder cancer among men and women is roughly 5:2, and both its incidence and death have been rising steadily over the past few years. At the moment, metastasis and recurrence of advanced bladder cancer—which are believed to be connected to the malfunction of multigene and multilevel cell signaling network—remain the leading causes of bladder cancer-related death. The therapeutic treatment of bladder cancer will be greatly aided by the elucidation of these mechanisms. New concepts for the treatment of bladder cancer have been made possible by the advancement of research technologies and a number of new treatment options, including immunotherapy and targeted therapy. In this paper, we will extensively review the development of the tumor microenvironment and the possible molecular mechanisms of bladder cancer.
DSCAM-AS1 promotes the development of prostate cancer
Authors: Cheng Lin , Li Shuhui , Jiang Deqi , Zhang Jianchao
Published: April 2024

Purpose

The purpose of this study was to investigate the role of lncRNA DSCAM-AS1 in prostate cancer to find new therapeutic targets and promote the research progress of prostate cancer.

Methods

RT-qPCR was used to detect DSCAM-AS1 expression in prostate cancer tissues, normal tissues, human normal prostate epithelial cells (RWPE), and four prostate cancer cell lines. The clinical and prognostic role of DSCAM-AS1 was evaluated by the Kaplan–Meier curve and chi-square test. Secondly, a dual luciferase reporter gene assay was used to study the regulatory mechanism between miR-338-3p and DSCAM-AS1. Finally, the roles of DSCAM-AS1 and miR-338-3p in prostate cancer cell proliferation and metastasis were explored by CCK-8 and Transwell assays.

Results

It was found that DSCAM-AS1 upregulation could serve as a warning of deterioration and poor prognosis in prostate cancer patients, and that knockdown of DSCAM-AS1 expression inhibited the progression of prostate cancer cells. In addition, miR-338-3p, a target of DSCAM-AS1, was found to be down-regulated in prostate cancer cells and miR-338-3p knockdown could reverse the inhibitory effect of DSCAM-AS1 silencing on prostate cancer.

Conclusion

DSCAM-AS1 is up-regulated in prostate cancer and regulates the progression of prostate cancer cells by targeting miR-338-3p.
Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association
Authors: Luo Huanhuan , Zheng Zitian , Hu Huixiu , Sun Chao
Published: April 2024

Background

Frailty, a clinical syndrome intricately linked with the aging process, stands as a harbinger of numerous adverse outcomes, most notably mortality. This study aimed to elucidate the association between serum α-klotho concentration and mortality patterns, including all-cause and cause-specific mortality, in patients with frailty.

Methods

The study employed Cox proportional hazard models, smoothed curve fitting, and supplementary analyses, encompassing threshold effect analysis, subgroup and sensitivity analyses, to explore the relationship between α-klotho levels and mortality, including all-cause, CVD, and cancer-related mortality.

Results

Among the 2,608 frail individuals (mean age: 60.78 [SD 10.48] years; 59.89% female), the mortality stood at 25.35% during a median follow-up period of 6.95 years. Both unadjusted and adjusted models revealed a significant inverse association between higher serum α-klotho levels and the risk of all-cause and CVD-related mortality ([mean(95% CI) 0.68 (0.55, 0.83)] for all-cause mortality; [mean(95% CI) 0.48 (0.32, 0.74)] for CVD-related mortality, all P for trend < 0.001). Notably, log2–klotho displayed a U-shaped correlation with all-cause mortality and cancer mortality, characterized by thresholds of 9.48 and 9.55, respectively. The robustness of these findings was consistently supported by subgroup and sensitivity analyses.

Conclusion

This study unveils a U shaped association between serum α-klotho levels and both all-cause and cancer-related mortality among middle-aged and elderly individuals with frailty in the United States. The identified serum α-klotho thresholds, at 714.8 pg/ml for all-cause mortality and 750.6 pg/ml for cancer-related mortality, hold promise as potential targets for interventions aimed at mitigating the risks of premature death and cancer within this vulnerable population.
Analysis of fractional differential equation to compare the dynamic behavior of a single degree of freedom system models using a shaking table
Authors: Márquez Erick , Romo Miguel , Hermosillo Armando , Brambila Fernando , Magaña Roberto
Published: April 2024

A mathematical model to describe the dynamic behavior of a single degree of freedom system, SDFS, model in springs and damps assembles in series and parallel models in a laboratory, is presented. Kelvin–Voigt fractional derivative rheological models, KVFRdm, was used to solve the fractional differential equations of motion by numerical methods.
Cross diffusion effects on MHD double diffusive viscous flow through Hermite wavelet method
Authors: Nagappanavar Suma Nagendrappa , Raghunatha K. R. , Kumar D. L. Kiran
Published: April 2024

Double-diffusive convection is a form of fluid flow that occurs when two processes of molecular diffusion are active in a fluid at the same time, causing instabilities and also complicated behaviour. One chemical or biological species concentration can cause a flux of another species, either linearly or nonlinearly, a phenomenon known as cross-diffusion. The cross-diffusion effects on double-diffusive MHD fluid flow through the Hermite wavelet method is examined. The governing coupled partial differential equations of the problem under consideration are transformed to highly nonlinear ordinary differential equations over a finite domain with the help of similarity transformations. The results are obtained for the skin friction coefficient, as well as the velocity, temperature and the concentration profiles for some values of the governing parameters, namely, the cross diffusion terms, Hartmann number, thermophoresis parameter, squeeze number, Prandtl number and suction/injection parameter. The obtained results are validated against previously published results for special case of the problems.
Making Sense of the Great War
Authors: Mayhew Alex
Published: April 2024

The First World War was an unprecedented crisis, with communities and societies enduring the unimaginable hardships of a prolonged conﬂict on an industrial scale. In Belgium and France, the terrible capacity of modern weaponry destroyed the natural world and exposed previously held truths about military morale and tactics as falsehoods. Hundreds of thousands of soldiers suffered some of the worst conditions that combatants have ever faced. How did they survive? What did it mean to them? How did they perceive these events? Whilst the trenches of the Western Front have come to symbolise the futility and hopelessness of the Great War, Alex Mayhew shows that English infantrymen rarely interpreted their experiences in this way. They sought to survive, navigated the crises that confronted them, and crafted meaningful narratives about their service. Making Sense of the Great War reveals the mechanisms that allowed them to do so.
Brotherhood of Barristers
Authors: Pepitone Ren
Published: April 2024

How did ideas of masculinity shape the British legal profession and the wider expectations of the white-collar professional? Brotherhood of Barristers examines the cultural history of the Inns of Court – four legal societies whose rituals of symbolic brotherhood took place in their supposedly ancient halls. These societies invented traditions to create a sense of belonging among members – or, conversely, to marginalize those who did not fit the profession's ideals. Ren Pepitone examines the legal profession's efforts to maintain an exclusive, masculine culture in the face of sweeping social changes across the nineteenth and twentieth centuries. Utilizing established sources such as institutional records alongside diaries, guidebooks, and newspapers, this book looks afresh at the gendered operations of Victorian professional life. Brotherhood of Barristers incorporates a diverse array of historical actors, from the bar's most high-flying to struggling law students, disbarred barristers, political radicals, and women's rights campaigners.
Flight performance analysis of aerial fire fighting
Authors: Struminska A. , Filippone A.
Published: April 2024

This paper investigates the operational patterns and techniques of aerial fire fighting. It is demonstrated that manoeuvrability and endurance are the main characteristics when choosing air tactical aircraft; focus is on load capability for helicopters and air tankers. Water tank filling and deployment techniques are evaluated. Aircraft using pressure deployment systems are found to produce more uniform and heavy coverage in comparison with gravity systems. ADS-B open source data of flight operations and performance was collected. Operational patterns are found to be independent on the size of particular aircraft category (non-amphibious and amphibious air tanker, helicopter, air-tactical aircraft). Effectiveness and cost are modelled using the retardant dropped per operation and the average number of daily missions. The largest aircraft, Type-I helicopters and very large air tankers (VLAT) are found to be the most effective water- and retardant-dropping aircraft. The best cost-to-litre-dropped ratio for water-dropping aircraft is attributed to Type-III helicopters and amphibious Type-III aircraft; for retardant-dropping aircraft, VLAT are most effective. To maximise fire fighting effectiveness, Type-I helicopters and VLAT should be used as far as possible, with pressure deployment systems.
Machine Learning with High-Cardinality Categorical Features in Actuarial Applications
Authors: Avanzi Benjamin , Taylor Greg , Wang Melantha , Wong Bernard
Published: April 2024

High-cardinality categorical features are pervasive in actuarial data (e.g., occupation in commercial property insurance). Standard categorical encoding methods like one-hot encoding are inadequate in these settings.

In this work, we present a novel Generalised Linear Mixed Model Neural Network (“GLMMNet”) approach to the modelling of high-cardinality categorical features. The GLMMNet integrates a generalised linear mixed model in a deep learning framework, offering the predictive power of neural networks and the transparency of random effects estimates, the latter of which cannot be obtained from the entity embedding models. Further, its flexibility to deal with any distribution in the exponential dispersion (ED) family makes it widely applicable to many actuarial contexts and beyond. In order to facilitate the application of GLMMNet to large datasets, we use variational inference to estimate its parameters—both traditional mean field and versions utilising textual information underlying the high-cardinality categorical features.

We illustrate and compare the GLMMNet against existing approaches in a range of simulation experiments as well as in a real-life insurance case study. A notable feature for both our simulation experiment and the real-life case study is a comparatively low signal-to-noise ratio, which is a feature common in actuarial applications. We find that the GLMMNet often outperforms or at least performs comparably with an entity-embedded neural network in these settings, while providing the additional benefit of transparency, which is particularly valuable in practical applications.

Importantly, while our model was motivated by actuarial applications, it can have wider applicability. The GLMMNet would suit any applications that involve high-cardinality categorical variables and where the response cannot be sufficiently modelled by a Gaussian distribution, especially where the inherent noisiness of the data is relatively high.
Exploring Volunteer Pharmacists’ Experiences in Responding to 2023 Türkiye Earthquakes: A Qualitative Phenomenological Study
Authors: Uzun Mehmet Barlas , Gülpınar Gizem , Iqbal Ayesha
Published: April 2024

Objective:

Pharmacists are vital in disaster response efforts, dispensing essential medications, managing pharmacy services, consulting, and educating survivors regarding their medications. Their contributions, however, are often underrepresented in scientific literature. This study aimed to explore the experiences of pharmacists who provided pharmacy services to meet the pharmaceutical needs of the survivors after 2 major earthquakes in Türkiye in 2023.

Methods:

This study adopted a phenomenological approach. Data were collected using semi-structured interviews. Purposive sampling was used to invite pharmacists who provided pharmacy services to survivors. Interview transcripts were analyzed following an inductive, reflexive thematic analysis.

Results:

In total, 15 pharmacists were interviewed. Four main overarching themes “response to the earthquake,” “preparedness for the earthquake,” “experiences during service delivery,” and “mental and physical experiences” were developed.

Conclusions:

From participants’ experiences, it is essential to expand the clinical responsibilities of pharmacists and train them in providing wound care, administering immunization, and prescribing. Pharmacists should be integrated as essential members of disaster health teams. International health organizations, nongovernmental organizations, and governments are encouraged to work collaboratively and develop disaster management plans including pharmacists in early responders. This might help mitigate the deficiencies and overcome challenges in health-care systems to provide effective patient-centered care by health professionals and respond effectively to disasters.
Rescuing Hegel from Eurocentrism: Oriental Reconstructions of Hegel's Orient
Authors: Murthy Viren
Published: April 2024

Hegel's Eurocentrism has become something of an elephant in the room, too obvious to merit discussion. The secondary literature on Hegel often concedes that many of Hegel's comments about the Orient are misguided and uninformed, and then declares that such remarks are of no consequence to his philosophy. However, recently, some scholars have contended that Hegel's view of freedom is fundamentally connected to his negative vision of the Orient and Africa. For example, Alison Stone asserts that Hegel's idea of freedom is premised on his Eurocentrism and colonialism. Drawing on Peter Sahota's essay on Hegel and Hinduism, she argues that Hegel's idea of freedom as liberation from nature tends to exclude non-Western conceptions of freedom. If Stone's contention is true, there would be no way to, as she puts it, save Hegel from himself. I argue that we can move some way towards rescuing Hegel by noting how scholars from modern Asia incorporated some of Hegel's ideas to struggle against Eurocentrism. This essay will read Hegel's comments on the Orient in light of his larger philosophy and then examine how Japanese scholars, specifically Okakura Tenshin (1863–1913) construct what could be called a Hegel-inspired defense of the concept of Asia or the Orient. I claim that if one understands the excesses of Western life to be linked to a vision of freedom based merely on self-interest and pleasure, when scholars and activists from Asia question Western culture, they actually follow Hegel's insights. Okakura, who studied Hegel in college, rethought Asia as overcoming the abstract individualist freedom of the West and replacing it a more holistic, and partially, Hegelian form of freedom.
Behavioral economics enhancers
Authors: Yechiam Eldad
Published: April 2024

Recent meta-analyses suggest that certain drugs act as cognitive enhancers and can increase attentional investment and performance even for healthy adults. The current review examines the potential of behavioral economics enhancers (BEEs) for similarly improving cognitive performance and judgments. Traditionally, behavioral economics theory has adopted a skeptical approach regarding the notion of whether individuals can overcome judgment biases through variables that increase cognitive effort. We focus mostly on the effects of two BEEs: incentivization and losses. Summarizing results from different meta-analyses, we find a small but robust positive effect size for BEEs, with comparable effect sizes to those found in studies of pharmacological cognitive enhancers.
New momentum integral equation applicable to boundary layer flows under arbitrary pressure gradients
Authors: Wei Tie , Li Zhaorui , Wang Yanxing
Published: April 2024

By incorporating the traditionally overlooked advective term in the wall-normal momentum equation, a new momentum integral equation is developed for two-dimensional incompressible turbulent boundary layers under arbitrary pressure gradients. The classical Kármán's integral arises as a special instance of the new momentum integral equation when the pressure gradient is weak. The new momentum integral equation's validity is substantiated by direct numerical simulation data. Unlike the classical Kármán's integral, which is limited to predicting wall shear stress within mild pressure gradients, the new momentum integral equation accurately computes wall shear stress across a broad range of pressure gradients, even in the presence of strong adverse pressure gradients that lead to flow separation. Moreover, a new pressure parameter

$\beta _\kappa$

is introduced through examining terms in the new momentum integral equation. This parameter naturally quantifies the pressure gradient's influence on turbulent boundary layers and offers guidance for applying the classical Kármán's integral. Additionally, to facilitate experimental determination of wall shear stress under strong pressure gradients, an approximate integral equation is proposed that relies solely on easily measurable variables. Validation against direct numerical simulation data demonstrates that this simplified equation provides reasonably accurate estimates of wall shear stress in turbulent boundary layers experiencing strong pressure gradients.
A Postcolonial Legal Critique of Online Expression in Africa
Authors: Ilori Tomiwa
Published: April 2024

Far beyond the contributions of African and western thought on the right to freedom of expression, there are now normative developments under international human rights law on how states can protect online expression. However, these developments are not applied in African countries. A reason for this is the extant provisions in various laws that threaten online expression. This article applies postcolonial legal theory to understand why and how these provisions threaten online expression in African countries. It identifies relevant thoughts on the right to freedom of expression, normative developments on the right and a new form of digital colonialism in Africa. It concludes that for African states and other actors to combat this new form of digital colonialism head-on, they must carry out targeted legal reform that repeals and amends these provisions.
Adolescent OCD Patient and Caregiver Perspectives on Identity, Authenticity, and Normalcy in Potential Deep Brain Stimulation Treatment
Authors: Smith Jared N. , Dorfman Natalie , Hurley Meghan , Cenolli Ilona , Kostick-Quenet Kristin , Storch Eric A. , Lázaro-Muñoz Gabriel , Blumenthal-Barby Jennifer
Published: April 2024

The ongoing debate within neuroethics concerning the degree to which neuromodulation such as deep brain stimulation (DBS) changes the personality, identity, and agency (PIA) of patients has paid relatively little attention to the perspectives of prospective patients. Even less attention has been given to pediatric populations. To understand patients’ views about identity changes due to DBS in obsessive-compulsive disorder (OCD), the authors conducted and analyzed semistructured interviews with adolescent patients with OCD and their parents/caregivers. Patients were asked about projected impacts to PIA generally due to DBS. All patient respondents and half of caregivers reported that DBS would impact patient self-identity in significant ways. For example, many patients expressed how DBS could positively impact identity by allowing them to explore their identities free from OCD. Others voiced concerns that DBS-related resolution of OCD might negatively impact patient agency and authenticity. Half of patients expressed that DBS may positively facilitate social access through relieving symptoms, while half indicated that DBS could increase social stigma. These views give insights into how to approach decision-making and informed consent if DBS for OCD becomes available for adolescents. They also offer insights into adolescent experiences of disability identity and “normalcy” in the context of OCD.
Active citizen or pest? Civic authorities, democratization and citizenship in inter-war England
Authors: Ryder Lewis
Published: April 2024

In the 1920s, the art collector John Hilditch tirelessly undertook a public campaign to have his objects exhibited at the Manchester City Art Gallery. This article uses his struggle as a lens through which to examine how the relationship between the civic museum and its citizens was reshaped during the transition to mass democracy. Historians have explored how civic authorities responded to the challenge of mass democratization by encouraging their citizens to become ‘active’, but we know little about how the citizens responded to this call. Hilditch’s campaign allows us to see what public platforms citizens could negotiate to become ‘active’ citizens, and just how far they could influence civic policy.
Bedside-Teaching zum Thema Demenz und Delir
Authors: Radler Andreas , Ewers Andre
Published: April 2024

Zusammenfassung: Hintergrund: Der demografische Wandel und der damit einhergehende Anstieg an Menschen mit Demenz und Delir im Akutkrankenhaus stellt die Pflegenden auf Bettenstationen im Akutbereich vor wachsende Herausforderungen. Ziel: Entwicklung, Implementierung und Evaluation eines Bedside-Teaching-Konzeptes. Pilotierende Umsetzung und Evaluation des Wissenszuwachses und der Umsetzung von zuvor definierten kritischen Verhaltensweisen. Methode: Durchführung der Schulungen durch APNs. Parallele Evaluation der Schulung entlang des New World Kirkpatrick-Modells mittels Fragebogen und nicht teilnehmender Beobachtung. Auswertung der Daten mittels deskriptiver Statistik. Ergebnisse: Die Schulung selbst, wurde von den Teilnehmenden gut bewertet. Es zeigte sich bei den Teilnehmenden ein Wissenszuwachs in den überblickenden Hauptthemenkategorien. Die angestrebten kritischen Verhaltensweisen werden zum Großteil umgesetzt. Mängel gibt es bei der Abbildung der Interventionen im Pflegeprozess. Schlussfolgerung: Das Schulungskonzept eignet sich, um den Pflegenden Sicherheit im Umgang mit Menschen mit Demenz und Delir zu geben. Um die Interventionen langfristig und nachhaltig im Alltag beizubehalten, bedarf es einer kontinuierlichen Begleitung in der Praxis.
Does Boundary Extension Need Attention?
Authors: Gaudouin Florence , Ménétrier Emmanuelle , Didierjean André
Published: April 2024

Abstract: When we look at a picture, we tend to remember it by enriching the constructed mental representation with elements not present but probable outside the current view. The tendency to remember the perceived view with a broader scope is known as boundary extension (BE). Does BE benefit from paying reduced attention to the picture? While attention plays a central role in memory, only a few studies to date have investigated this question in the field of BE. In this research, participants completed a BE task in single- and dual-task conditions. The results indicate that BE is eliminated when the attention is divided on the onset of scene construction. We therefore discuss the role of attention in BE.
The Time Course of Information Processing During Eye Direction Perception
Authors: Babinet Marie-Noëlle , Demily Caroline , Gobin Eloïse , Laurent Clémence , Maillet Thomas , Michael George A.
Published: April 2024

Abstract: Gaze directed at the observer (direct gaze) is a highly salient social signal. Despite the existence of a preferential orientation toward direct gaze, none of the studies carried out so far seem to have explicitly studied the time course of information processing during gaze direction judgment. In an eye direction judgment task, participants were presented with a sketch of a face. A temporal asynchrony was introduced between the presentation of the eyes and that of the rest of the face. Indeed, the face could be presented before the eyes, the eyes could be presented before the face, or the face and the eyes could be presented simultaneously. In a second time, the face direction was also manipulated. The results suggest that the time course of information processing during eye direction judgment follows a continuum that makes it possible to perceive the eyes first and then to use the facial context to judge the direction of gaze. Furthermore, the congruency between the direction of gaze and that of the face confirms this observation. Although these results are discussed in the light of existing theories about the mechanisms underlying gaze processing, our data provide new information suggesting that, despite their power to capture attention, the eyes probably have to stand out from a more general spatial configuration (i.e., the face) in order for their direction to be adequately processed.
Non‐Double‐Couple Components of Seismic Source: Method and Application to the 2014–2015 Bárðarbunga Volcanic Event Sequence, Iceland
Authors: Xu Yanyan , Wen Lianxing
Published: April 2024

Genuine non‐double‐couple (non‐DC) components of a seismic source, defined here as the non‐DC components that are not due to summation of pure double‐couple (DC) components, provide important insight into special physical processes in non‐earthquake sources such as explosion, volcano eruption and collapse etc. Yet they remain challenging to be resolved. To address the issue and explore the physical mechanism of those special events, we develop a waveform‐polarity‐based moment tensor (WPMT) inversion method and employ it to study physical process in the 2014–2015 Bárðarbunga volcano event sequence. The WPMT method incorporates P‐wave polarity data and seismic waveforms in the source inversion, designs a source simplicity test to check possible complex rupture in the seismic source, and employs a simulated annealing algorithm to search the best source solution. The simplicity test checks consistency of the source processes in the initiation stage of the event and the major energy release process of the event, thus ensuring that the inferred non‐DC components are genuine to the seismic source. Real event and synthetic tests indicate that the WPMT method can identify and resolve genuine non‐DC components in a seismic source. The WPMT inversions of the Bárðarbunga sequence yield many genuine non‐DC source components and reveal that the eruptions are accompanied by seismic activities in depths of 1–5 km with magma migrations out of chambers, collapses of conduits, failures of normal faults, and a magma recharge at a depth of 9 km accompanied by a failure on a nearby normal fault.
Combined approaches, including long-read sequencing, address the diagnostic challenge of HYDIN in primary ciliary dyskinesia
Authors: Fleming Andrew , Galey Miranda , Briggs Lizi , Edwards Matthew , Hogg Claire , John Shibu , Wilkinson Sam , Quinn Ellie , Rai Ranjit , Burgoyne Tom , Rogers Andy , Patel Mitali P. , Griffin Paul , Muller Steven , Carr Siobhan B. , Loebinger Michael R. , Lucas Jane S. , Shah Anand , Jose Ricardo , Mitchison Hannah M. , Shoemark Amelia , Miller Danny E. , Morris-Rosendahl Deborah J.
Published: April 2024

Primary ciliary dyskinesia (PCD), a disorder of the motile cilia, is now recognised as an underdiagnosed cause of bronchiectasis. Accurate PCD diagnosis comprises clinical assessment, analysis of cilia and the identification of biallelic variants in one of 50 known PCD-related genes, including HYDIN. HYDIN-related PCD is underdiagnosed due to the presence of a pseudogene, HYDIN2, with 98% sequence homology to HYDIN. This presents a significant challenge for Short-Read Next Generation Sequencing (SR-NGS) and analysis, and many diagnostic PCD gene panels do not include HYDIN. We have used a combined approach of SR-NGS with bioinformatic masking of HYDIN2, and state-of-the-art long-read Nanopore sequencing (LR_NGS), together with analysis of respiratory cilia including transmission electron microscopy and immunofluorescence to address the underdiagnosis of HYDIN as a cause of PCD. Bioinformatic masking of HYDIN2 after SR-NGS facilitated the detection of biallelic HYDIN variants in 15 of 437 families, but compromised the detection of copy number variants. Supplementing testing with LR-NGS detected HYDIN deletions in 2 families, where SR-NGS had detected a single heterozygous HYDIN variant. LR-NGS was also able to confirm true homozygosity in 2 families when parental testing was not possible. Utilising a combined genomic diagnostic approach, biallelic HYDIN variants were detected in 17 families from 242 genetically confirmed PCD cases, comprising 7% of our PCD cohort. This represents the largest reported HYDIN cohort to date and highlights previous underdiagnosis of HYDIN-associated PCD. Moreover this provides further evidence for the utility of LR-NGS in diagnostic testing, particularly for regions of high genomic complexity.
Predictors of severe hepatotoxicity among retroviral infected adults on HAART regimen in Ilubabor Zone, Southwest Ethiopia
Authors: Darge Tefera , Babusha Alemayehu , Chilo Dessalegn , Dukessa Abebe , Teferi Sisay
Published: April 2024

Nearly half of the deaths among hospitalized human immuno deficiency virus-infected patients in the highly active antiretroviral therapy era have been attributed to liver disease. This may range from an asymptomatic mild increase of liver enzymes to cirrhosis and liver failure. Different works of literature elucidated both retroviral infection and the adverse effects of highly active antiretroviral therapy as a cause of hepatotoxicity. Individual adaptations to medications and environmental exposures, shaped by cultural norms and genetic predispositions, could potentially modulate the risk and progression of liver disease in this population. Therefore, this study aims to assess the predictors of severe hepatotoxicity in retroviral-infected adults receiving highly active antiretroviral therapy regimens within the Ilubabor Zone, Southwest Ethiopia. A facility-based cross-sectional study was conducted among adult retroviral-infected patients in five selected anti-retro virus therapy clinics from May1 to July 30/2022. A systematic sampling technique was used to select 457 study participants and Binary logistic regression statistical data analysis was used, P value < 0.05 was considered statistically significant. The prevalence of severe hepatotoxicity was 21.44% in the study population. CD+4 count < 200 cells/mm3 (AOR = 2.19, 95% CI 1.04–5.22, P = 0.01), human immunodeficiency virus co-infection with tuberculosis (AOR = 2.82, 95% CI 1.01–8.29, P = 0.03) and human immuno deficiency virus co-infection with hepatitis-B/hepatitis C virus (AOR = 5.02, 95% CI 1.82–16.41) were predictors of severe hepatotoxicity. The magnitude of severe hepatotoxicity was high among adult retroviral-infected patients on highly active anti-retroviral drug regimens. Co-infection of human immuno deficiency virus with hepatitis B virus or hepatitis C virus, tuberculosis and CD4+T-cell count below 200 cells/mm3 were predictors of severe hepatotoxicity. Therefore, HIV patients on highly active antiretroviral therapy require close attention and regular monitoring of their liver function.
Quantitative performance assessment of Ultivue multiplex panels in formalin-fixed, paraffin-embedded human and murine tumor specimens
Authors: Ram Sripad , Mojtahedzadeh Sepideh , Aguilar Joan-Kristel , Coskran Timothy , Powell Eric L. , O’Neil Shawn P.
Published: April 2024

We present a rigorous validation strategy to evaluate the performance of Ultivue multiplex immunofluorescence panels. We have quantified the accuracy and precision of four different multiplex panels (three human and one mouse) in tumor specimens with varying levels of T cell density. Our results show that Ultivue panels are typically accurate wherein the relative difference in cell proportion between a multiplex image and a 1-plex image is less than 20% for a given biomarker. Ultivue panels exhibited relatively high intra-run precision (CV ≤ 25%) and relatively low inter-run precision (CV >> 25%) which can be remedied by using local intensity thresholding to gate biomarker positivity. We also evaluated the reproducibility of cell–cell distance estimates measured from multiplex images which show high intra- and inter-run precision. We introduce a new metric, multiplex labeling efficiency, which can be used to benchmark the overall fidelity of the multiplex data across multiple batch runs. Taken together our results provide a comprehensive characterization of Ultivue panels and offer practical guidelines for analyzing multiplex images.