bluuebunny/crossref_metadata_2025 huggingface dataset:
Transformações sociais e interações escola-família no ensino fundamental
Authors: Poli Odilon Luiz , Zago Nadir , Bortoleto Edivaldo José
Published: January 2020

A literatura consultada e o discurso dos professores indicam uma “tensão” existente entre escola e família. Esta pesquisa teve por objetivo caracterizar as concepções de família e seu papel no processo de escolarização dos filhos presentes no discurso de professores de redes municipais de ensino no Oeste catarinense. Os dados foram coletados, via questionário, com 111 professores de cinco municípios, escolhidos mediante critérios. Os resultados indicam saber docente apoiado num modelo idealizado de família nuclear e na falta de elementos conceituais para a compreensão das transformações em curso.
Aos 7 e aos 40: uma conversa sobre a vida
Authors: Guimarães Cristiane
Published: January 2020

O Livro Aos 7 e aos 40, de João Anzanello Carrascoza, lançado em 2016 pela Editora Alfaguara e reimpresso em 2018, é um livro leve, simples e sugestão de leitura para aqueles que sabem valorizar vozes narrativas contemporâneas que nos levem a habitar outros tempos e espaços. É um livro-convite à vida, à poesia e às artes do narrar no nosso tempo.

No livro, é tecida uma conversa dos momentos da vida e suas estações, a vida e seus tempos, dois mundos que se encontram ou se afastam, expandem-se e se retraem no cotidiano silencioso e quase indizível da meninice e da vida adulta. Com voz suave, desenhando o cotidiano narrado, os protagonistas-narradores dividem-se em contar seus mundos, seus olhares, emoções e afetos nas 112 páginas, em loopings e zooms constantes e ritmados, nos levando, na leitura, re-parar o fio da vida miúda e o que ela nos tem a dizer.
Condiciones de cuidado en cuidadores de pacientes en dialisis peritoneal asociadas a sobrecarga
Authors: Franco Mejia Viviana Pahola , Romero Massa Elizabeth
Published: January 2020

Introducción: El cuidador de un familiar de persona con Enfermedad Renal Crónica en tratamiento ambulatorio, genera momentos críticos relacionados con el estrés de cuidar.Por lo que este estudio pretende determinar las condiciones del cuidado en cuidadores de pacientes en diálisis peritoneal asociadas a sobrecarga.

Métodos: Estudio analítico, la población y muestra la constituyeron 128 cuidadores de pacientes en la región Caribe. Mediante encuesta de Caracterización del cuidador, escala de sobrecarga de Zarit, con 0.90 de alpha de Cronbach y Cuestionario de sobrecarga completa de familiares de pacientes en DP, con coeficiente de Cronbach de a= 0.847, losdatos se expresaron en frecuencias y promedios la asociación se determinó con U Mann Whitney, significativa

Resultados: Predominó el género femenino, la edad promedio de cuidadores fue de 43,8 años. De las condiciones de cuidado de los cuidadores con 68,8% predominó ser únicos cuidadores, 37,5% con 1 a 3 años cuidando y 33,6%. Madre opadre. La ausencia de sobrecarga la percibieron el 78,9% de cuidadores, se encontró sobrecarga por dependencia del paciente en 57,0% de cuidadores, mucha sobrecarga en 92,2% y mucha repercusión en 85,2%. Las condiciones de cuidado asociada a la sobrecarga en cuidadores fue cuidar a la persona desde el momento del diagnóstico (p 0,003)Conclusión: Los cuidadores de pacientes en Diálisis Peritoneal en la región caribe, percibieron una baja proporción de sobrecarga intensa y ligera que se asoció con cuidar desde el momento del diagnóstico.
Structural Characterization and Thermal Properties of the Anti-malarial Drug: Lumefantrine
Authors: Pansuriya Pramod B. , Glenn E.M. Glenn E.M. , Friedrich Holger B.
Published: January 2020

The anti-malarial lumefantrine was characterized in the solid as well as the solution state. The solid state analysis was carried out by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), DSC, TG-DTG and ATR-IR. The single crystal structure of lumefantrine has been solved. The structure is stabilized via inter- as well as intra-C-H...Cl interactions, intra hydrogen bonding O-H.. .N interactions and C-H.. .O weak interactions. The Hirshfeld surface intermolecular interactions have been studied using the crystal structure. Solution structure analyses have been done by NMR, COSY/NOESY, HSQC and mass spectrometry. The thermal properties were studied by solid-state differential scanning calorimetry and thermogravimetric analysis of the drug under nitrogen as well as in air. Keywords: Single crystal structure, lumefantrine, 2D NMR, DSC, PXRD.
Anecdotari artanenc
Authors: Rosselló Bover Pere
Published: January 2020

Ginard Bauçà, Rafel: Anecdotari artanenc. Palma: Edicions Documenta Balear, 2018, 132 p.
Notícies
Authors: Ocete Marí Alejandro , Muñoz Marzá Tània , Gargallo i Barea Olga
Published: January 2020

V Jornada de la Càtedra BaixerasSom RondallaXIV Trobada del Grup d’Estudis Etnopoètics
The regulation of private conservation legal tools in Catalonia: an inspiring precedent for the Roman law jurisdictions
Authors: Collado Urieta Hernan
Published: January 2020

In the first decade of the XXI century, Catalonia has successfully received Land Stewardship as a strategy for nature conservation. As a result, many efforts have been taken to regulate Land Stewardship agreements in the Catalan civil law given the great opportunity of the Catalan private law codification that has taken place in Catalonia during the present and previous decade. For this purposes, all features of these agreements, such as duration, effects and nature have been thoroughly studied giving place to specific provisions in the Civil Code of Catalonia. This unique experience is studied in this article, extracting the key elements, learning and suggestions leading to some guidelines for a European common roadmap to the regulation of land Stewardship agreements.
Evaluación de riesgos derivados de los organismos modificados genéticamente y la adopción de medidas de emergencia en el marco de la Unión Europea
Authors: Bachmann Fuentes Ricardo Ignacio
Published: January 2020

The European Commission and the Court of Justice of the European Union consider that an emergency measure only can be adopted in accordance with Article 34 of Regulation (EC) No. 1829/2003, 53 and 54 of Regulation (EC) No. 178/2002, before the verification of a serious risk derived from Genetically Modified Organisms. According to Community law, which is the result of a regulatory evolution developed during the last decades, this verification must be realized in the risk analysis procedure, specifically during the risk assessment. Therefore, the objective of this article is to analyze the elements of this stage, mainly the concepts of biotechnological risk and scientific uncertainty, which are closely linked to the precautionary principle. Consequently, the interpretation and application of this principle is also analyzed in the jurisprudence of the Court of Justice of the European Union.
A revisibilidade da concessão de licença ambiental à luz da controvérsia da discricionariedade administrativa dos atos ambientais
Authors: Moura Emerson Affonso da Costa , Vazquez Barreira Ranzeiro de Bragança Davi
Published: January 2020

It is intended to analyze the revisability of the act of granting an environmental license in light of its discretionary or related legal nature. For this, an analysis of administrative discretion is made in the light of its transformations and its interface with environmental law. After a study of the relationship between environmental licensing and administrative discretion in light of the different conceptions of legal literature. Finally, there is the issue of environmental licensing and revisability. It is concluded that there is a need for a state license (based on preventive and precautionary measures) of the environmental license granted, even though it is in full force of the concession act, because socioeconomic and environmental realities undergo modifications that may lead to the need to change the environmental license granted or even reviewed in the modalities specified above.
El Convenio de Albufeira: un análisis con motivo del vigésimo aniversario de su adopción
Authors: Álvarez Arcá Ignacio
Published: January 2020

In 1998 Spain and Portugal adopted the Albufeira Convention to manage shared water resources between both States. For the first time, environmental protection and sustainable management of water resources and dependent ecosystems became the main goal of the conventional relationships. Those relationships have been developed over more than hundred years, even though with other different goals. Now, in the twentieth anniversary of its adoption, it is a good moment to analyse the Convention, its past deficiencies and its future challenges. The Albufeira Convention is fully enforceable and can guarantee the protection and sustainability of the shared water resources for a further twenty years. However, the updating of the Water Framework Directive, that will take place this year, and the adoption of the Agenda 2030 provide the suitable context to deepen relationships and improve the Convention to face the threat of scarcity and drought, which are increasing due to climate change.
Jurisprudencia ambiental en La Rioja (Primer semestre 2019)
Authors: Muñoz Benito Lucía
Published: January 2020

Jurisprudencia ambiental en La Rioja (Primer semestre 2019)
Derecho y políticas ambientales en Asturias (Primer semestre 2019)
Authors: Boto Álvarez Alejandra
Published: January 2020

Derecho y políticas ambientales en Asturias (Primer semestre 2019)
Jurisprudencia ambiental internacional (Primer semestre 2019)
Authors: Fernández Egea Rosa Maria
Published: January 2020

Jurisprudencia ambiental internacional (Primer semestre 2019)
Derecho y Políticas ambientales en Andalucía (Primer semestre 2019)
Authors: Mora Ruiz Manuela
Published: January 2020

Crónica correspondiente a Andalucía Primer semestre 2019
Jurisprudencia ambiental en Andalucía (Primer semestre 2019)
Authors: Mellado Ruiz Lorenzo
Published: January 2020

Jurisprudencia ambiental en Andalucía (Primer semestre 2019)
Derecho y políticas ambientales en la Región de Murcia (Primer semestre 2019)
Authors: Alvarez Carreño Santiago Manuel
Published: January 2020

La presente crónica da cuenta de las novedades, algunas de bastante enjundia, de la política y legislación ambiental en la Región de Murcia durante este primer semestre del 2019. No obstante, nuestro fiel lector o lectora apreciará la inclusión de tres referencias producidas a finales del pasado año que, por su tardía fecha de aprobación, no pudieron ser más que aludidas en la anterior crónica pero que merecían, sin duda, una mirada un tanto más atenta en la presente ocasión. Por lo demás, el ambiente electoral impregna desde hace ya tiempo e impregnará hasta la aparición de esta crónica, todos los rincones de la escena pública y, de manera un tanto sorprendente para este atribulado cronista, las cuestiones ambientales no ocupan un espacio destacado en ninguna de las discusiones y debates siendo, como son sin duda, las más esenciales para la suerte de esta especie homínida y del resto de subyugadas especies que surcan el espacio interestelar a bordo de este planeta, otrora azul, llamado «Tierra» pero que bien hubiera podido llamarse mejor «Agua».
Derecho y Políticas ambientales en Castilla y León (Primer semestre 2019)
Authors: Sanz Rubiales Iñigo
Published: January 2020

Derecho y Políticas ambientales en Castilla y León (Primer semestre 2019)
Derecho y políticas ambientales en Asturias (Segundo semestre 2019)
Authors: Boto Álvarez Alejandra
Published: January 2020

Derecho y políticas ambientales en Asturias (Segundo semestre 2019)
Jurisprudencia ambiental en Andalucía (Segundo semestre 2019)
Authors: Mellado Ruiz Lorenzo
Published: January 2020

Jurisprudencia ambiental en X (Segundo semestre 2019)
Derecho y políticas ambientales en Aragón (segundo semestre 2019)
Authors: Herraiz Serrano Olga
Published: January 2020

Derecho y políticas ambientales en Aragón (segundo semestre 2019)
Jurisprudencia ambiental en Illes Balears (Segundo semestre 2019)
Authors: Gómez González Josep Manuel
Published: January 2020

Jurisprudencia ambiental en Illes Balears (Segundo semestre 2019)
Derecho y políticas ambientales en la Región de Murcia (Segundo semestre 2019)
Authors: Pérez de los Cobos Hernández Elisa
Published: January 2020

Derecho y políticas ambientales en la Región de Murcia (Segundo semestre 2019)
Jurisprudencia penal ambiental (Segundo semestre 2019)
Authors: Marqués Banquè Maria , Torres Rosell Núria
Published: January 2020

Jurisprudencia penal ambiental (Segundo semestre 2019)
In Memoriam Elena Górriz
Authors: González Cussac José Luis
Published: January 2020

In Memoriam Elena Górriz
Tejiendo redes desde la universidad al aula: creación de recursos didácticos para trabajar las Ciencias de la Naturaleza en Educación Infantil
Authors: Mateo González Ester , Dieste Gracia Belén , García Goncet Daniel
Published: January 2020

Con el objetivo de que nuestros estudiantes del Grado de Magisterio en Educación Infantil (EI) trabajen de manera globalizada, en conexión con la realidad del aula y siguiendo la metodología de Aprendizaje y Servicio (ApS), se ha diseñado una propuesta didáctica donde han estado involucradas 2 asignaturas obligatorias del Grado, 2 centros sociolaborales y 11 centros escolares. De manera que los futuros/as maestros/as tienen que: 1) elaborar materiales y recursos para trabajar las Ciencias en las aulas de EI junto con los alumnos de los centros sociolaborales; 2) diseñar actividades experimentales de Ciencias utilizando esos recursos y 3) implementar y evaluar sus acciones en el aula. La experiencia ha permitido a los estudiantes aprender a diseñar actividades para trabajar las Ciencias de forma global en EI, a colaborar y coordinarse con la escuela y con los centro sociolaborales y, en algunos casos, ha supuesto una transformación personal y social.
Didáctica de las ciencias, ¿de dónde venimos y hacia dónde vamos?
Authors: Álvarez Herrero Juan Francisco , Valls Bautista Cristina
Published: January 2020

La didáctica de las ciencias se considera una materia interdisciplinar ya que presenta competencias tanto en el área de las ciencias y de la historia de las ciencias como en el de la pedagogía y la psicología. Esta interdisciplinariedad hace que para los docentes de la didáctica de las ciencias no sea suficiente con tener una buena formación científica. Además de una buena formación en ciencias, en contenidos científicos y con otros provenientes de la filosofía y de la historia de las ciencias, es necesario que estén familiarizados con aquellos recursos, estrategias y habilidades que permitan la eficacia de los procesos de enseñanza-aprendizaje del alumnado, formación que proviene de la psicología y la pedagogía. Algunos autores creen que para desarrollar la didáctica de las ciencias es necesario que los docentes integren el conocimiento sobre el contenido con el conocimiento pedagógico (Duit, 2007).A pesar de ello, en nuestro país, desde antiguo y también en la actualidad, se viene tratando la didáctica de las ciencias como una transferencia de los contenidos científicos de cada una de las áreas que conforman las ciencias (física, química, biología, matemáticas…), de forma separada y de manera totalmente descontextualizada con los problemas de la sociedad actual.A pesar de todo este tiempo, la didáctica de las ciencias en España sigue atascada en estos problemas y otros temas recurrentes (Perales, 2018), que lejos de permitirle avanzar y evolucionar a mejor, han hecho que tenga un retroceso respecto a otras áreas y didácticas.
Zebrafish (Danio rerio) Environmental Summary, Aquatic Resources Program, Boston Children's Hospital 2019 v4
Authors: Lawrence Christian , Best Jason , James Althea , Hurley Shane , Shia Mitchel , Urh Michelle , Hirshfeld Brady , Bakker Nina , Perdomo Hugo
Published: January 2020

Environmental and housing conditions experienced by laboratory animals exert profound effects on their biology, physiology, and behavior. These parameters are important and often overlooked sources of potential variation in experiments, and should be reported in peer-reviewed publications in order to promote scientific reproducibility. To that end, here we provide a summary of the environmental conditionsin zebrafish (Danio rerio) aquaculture facilities at Boston Children's Hospital (BCH). We include data on the physico-chemical, health, and nutrition of zebrafish in three separate facilities at BCH: Karp, Enders SSB, and Enders Lobby. In this year's version, we also include new information on our sanitization protocol validation, and dietary inputs. We also provide some additional characterization of our sampling methods for water parameters and health in an updated legend. This information will be applicable to any study involving zebrafish conducted in one of these three facilities during the year of 2019.
Renal cell carcinoma: what’s new in 2019
Authors: Evsyukova О. I. , Matveev V. В.
Published: January 2020

This review of renal cell carcinoma describes new diagnostics and treatment standards, new guidelines from international professional organizations and key studies, published in 2019.
Bladder cancer: what’s new in 2018–2019
Authors: Karyakin О. В.
Published: January 2020

The review presents the results of the most important and interesting studies on diagnosis, epidemiology and treatment of bladder cancer within 2018–2019. Some regulations are based on the recommendations of the European Association of Urology, while others – on the results of mutual studies. As for treating non-muscle-invasive bladder cancer, data of particular interest pertain to intravesical chemotherapy in case of to BCG resistance (Calmet–Guerin Bacillus) for therapeutic and prophylactic purposes. Response rate and number of adverse reactions are satisfactory and allow to hope for better results in future. The results of epidemiological studies on large populations showed that considering the disease pathogenesis it is necessary to take into account the presence of human hepatitis HBAb, as well as human papillomavirus type 6. As immunotherapeutic drugs are widely used in patients with oncological and urological diseases, their action is studied in patients with nonmuscleinvasive, locally advanced bladder cancer. The results showed the effectiveness of pembrolizumab when administered intravesically in BCG refractory cancer. The same drugs used in the neoadjuvant mode showed an increase of pT0 number after radical cystectomy. A comparative study of pembrolizumab and atesolizumab versus traditional chemotherapy showed their advantage in the frequency of complete regressions and survival rates to progression.
Reconstructive plastic surgery for bladder cancer metastasis into urethra (case report)
Authors: Tillyashaykhov M. N. , Boyko E. V. , Rakhimov N. T. , Koren' L. P. , Khasanov Sh. T. , Abdusamatov N. T. , Ataboev A. Kh.
Published: January 2020

Due to few observations, a standard treatment scheme for metastatic cancer into urethra has not been developed yet. However it has become evident, that combined approach using neoadjuvant radiation or chemoradiotherapy together with surgical tumor removal, taking into account its location, size, local prevalence and metastases to regional lymph nodes, is much more effective. The article describes a clinical case of a secondary urethra metastatic lesion from bladder.
Clinical and genetic characteristics of patients with type 2 early infantile epileptic encephalopathy caused by CDKL5 gene mutations
Authors: Dadali E. L. , Akimova I. A. , Konovalov F. A. , Shatalov P. A. , Krasnenko A. Yu. , Strelnikov V. V. , Ampleeva M. A.
Published: January 2020

Early infantile epileptic encephalopathies (EIEE) are a group of disorders characterized by pharmacoresistant epileptic seizures manifesting in infancy and leading to psychomotor retardation. The most common genetic variant with X-linked dominant inheritance is type 2 EIEE associated with CDKL5 gene mutations. We evaluated the prevalence of this type of EIEE among Russian patients (n = 148) with epileptic seizures manifesting in infancy and analyzed their clinical and genetic characteristics. We performed exome sequencing for all patients; 15 (10 %) of them (aged between 2 months and 5 years) were found to have CDKL5 gene mutations and were, therefore, diagnosed with type 2 EIEE. The results of correlation analysis suggest that the severity of clinical manifestations of type 2 EIEE is largely determined by the location of mutations affecting the function of the protein encoded by this gene. This is important to ensure better understanding of type 2 EIEE etiology and predict it severity in patients with different allelic variants.
Safety and tolerability of antiepileptic therapy: emphasis on the use of valproates (literature review)
Authors: Pylaeva O. A. , Mukhin K. Yu.
Published: January 2020

Since epilepsy is a chronic disease of the nervous system that requires long-term therapy and regular intake of antiepileptic drugs, good tolerability of therapy is crucial for the quality of life of these patients. The main aim of antiepileptic treatment is the creation of a balance between the efficacy and tolerability of therapy. This literature review analyzes tolerability and safety of antiepileptic therapy. We paid particular attention to valproate, a drug that has been used for the treatment of epilepsy for more than 57 years. Valproate remains a basic drug with high efficacy and well-studied safety and tolerability. This review also covers the problems of epilepsy aggravation in response to some antiepileptic drugs, effects of antiepileptic drugs on cognitive functions, behavior, and mental sphere, as well as the issues of tolerability and safety of antiepileptic drugs in women of reproductive age.
Neurology in Russia: reality and the pursuit of ideal
Authors: Petrukhin A. S.
Published: January 2020

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THE APPLYING OF GIS INFORMATION TECHNOLOGIES IN THE SPHERE OF THE REMOTE SENSING OF THE EARTH TO SOLVE MILITARY PROBLEMS
Authors: Lytvynenko N.
Published: January 2020

The rapid development of geographic information systems and means of remote sensing, observed in recent decades, requires the mutual integration of these areas. This article focuses on the integration of geographic information systems and technologies in the field of remote sensing to solve military problems. Keywords: remote sensing, geographic information system.
MAP SEMIOTICS: A COMPLETE VIEW OF THE SCIENTIFIC LINGUISTIC CONCEPT OF MODERN CARTOGRAPHY THAT CLAIMS TO BE ITS GENERAL THEORY
Authors: Molochko A. , Molochko N.
Published: January 2020

The long history of cartography as a science, production and education shows that its general theory has always been consistent with the most urgent constantly changing requirements of society, making it an evolving scientific discipline, that develops nowadays in objective conditions of integration of sciences from various fields of knowledge : from natural to humanitarian sciences, methods of which are related. This integration process is perfectly illustrated by the theory of geo-images that focuses on the cognition of the peculiarities of the real-life objects representation forms obtained by related methods of various sciences. In our opinion, they have the affinity for the use of a single object language of cartography, the epistemological essence of which is proved in map semiotics, by virtue of which it is capable to occupy one of the most important content of the general theory of cartographic science. Key words: cartography, general theory, map-semiotics, linguistic concept, semiotic aspects of the content of the map, contour (form) of the sign.
Территориальная неоднородность глобализации и порождаемые ею типы конфликтов
Authors: Сергеев Виктор , Казанцев Андрей , Медведева Светлана
Published: January 2020

Целью статьи является выявление механизма взаимосвязи между, с одной стороны, наблюдающимся в настоящее время кризисом экономической глобализации, а с другой стороны, упадком американской гегемонии и ростом международных конфликтов. С этой целью проводится синтез теорий гегемонии в рамках неореализма, неолиберализма и мир-системного подхода. Указанный синтез проводится на основе теории транзакционной экономики (Д. Норт) и теории мегаполисов – “глобальных ворот”, представляющей собой анализ территориального распределения связей в транзакционной экономике (Д. Андерссон). С этой теоретической перспективы видны недостатки распространенной модели глобализации как территориально однородного процесса (модели “глобальной деревни”). Эта модель не дает объяснения того, почему после наблюдавшихся успехов глобализации в 1990-х – начале 2000-х годов мир перешел в этап роста различных конфликтов. Глобализация, с нашей точки зрения, предполагает территориальную неоднородность связей, за которой стоит социальная неравномерность распределения ресурсов в мире. Поддержание этой неоднородности требует гегемонии в мировой политике. В периоды снижения темпов экономического роста это приводит к особому росту конфликтов. Если период снижения роста и роста конфликтов совпадает с кризисом гегемонии (а именно это мы наблюдаем в настоящее время, особенно при администрации Д. Трампа), то усиливается кризис экономической глобализации. Возникает большой разрыв между потребностями мировой экономики в стабильности и неспособностью системы мировой политики ее обеспечить. В свою очередь, рост конфликтности за счет снижения степени предсказуемости, уменьшения взаимного доверия, гонки вооружений и т.п. создает новые вторичные циклы нестабильности. Указанные выше процессы составляют основу разворачивающегося многоуровневого кризиса глобализации. Проведенный анализ позволяет сформулировать три сценария развития кризиса глобализации (переход к “многополярному” глобальному управлению, частичный возврат на определенный период к американской гегемонии и “гегемоническая холодная война” между США и Китаем). Эти сценарии ранжированы по степени конфликтности и степени негативного влияния на мировую экономику. В зоне риска на период кризиса глобализации оказываются территории, находящиеся в “сфере экономического притяжения” разных групп “глобальных ворот”. К ним можно отнести постсоветское пространство.
Парламентская дипломатия: развитие общественно-государственного взаимодействия на мегаполитическом уровне
Authors: Коньков Александр , Чуков Роман
Published: January 2020

Статья базируется на результатах исследовательского проекта о роли парламентской дипломатии в современной политике, реализуемого аналитическим центром “Rethinking Russia” и Центром международного продвижения. Авторы изучают феномен парламентской дипломатии, анализируют его природу и истоки. Парламентский срез рассматривается как наиболее показательное институциональное сочетание государственной (парламент как официальный орган власти) и общественной (парламентарии являются представителями народа, гражданского общества) природы современной коммуникации на мегаполитическом уровне. Анализируются актуальные прикладные аспекты российской парламентской дипломатии как двустороннего, так и многостороннего характера, включая парламентские ассамблеи международных организаций – ОБСЕ, СНГ, ОДКБ, и ряда других. Акцентируются возможности парламента в преодолении вызовов, с которыми сталкивается современное государство.
Мерцающий секуляризм: религия в российском публичном пространстве
Authors: Малахов Владимир
Published: January 2020

В центре внимания авторов статьи находится тезис о десекуляризации российского государства. Сторонники данного тезиса утверждают, что в поведении российских властей просматривается отход от принципа секуляризма. Подвергая данный тезис критическому переосмыслению, авторы приходят к выводу, что он не выдерживает эмпирической проверки, и впечатление, будто российская власть разворачивается в противоположную от секуляризма сторону, иллюзорно. Наблюдатели становятся жертвой данной иллюзии по той причине, что не учитывают двух обстоятельств. Во-первых, рассогласования между публичной самопрезентацией власти (“символической политикой”) и ее практическими действиями (“инструментальной политикой”); во-вторых, разнонаправленного характера деятельности различных государственных институтов. На уровне символической политики власть в самом деле избегает четкой и бескомпромиссной демонстрации собственной светскости. Однако на уровне инструментальной политики отказа от секуляризма не происходит. Риторические упражнения, связанные с “православной” традицией или с традицией “многоконфессиональности”, не имеют значимых институциональных последствий.
Этноконфликтность в контексте национальной безопасности России
Authors: Найденко Виталий
Published: January 2020

Область этнонациональных отношений и возникающие на почве этих отношений конфликты входят в число приоритетных проблем обеспечения безопасности российских граждан, общества и государства. В октябре 2018 г. – марте 2019 г. методами анкетирования и глубинного интервью был проведен опрос 20 высококвалифицированных экспертов в этой области с целью определения степени важности различных составляющих национальной безопасности России, выявления роли и места этнонациональной сферы, определения степени опасности этнонациональных конфликтов, соотношения внешних и внутренних угроз для Российской Федерации. Результаты опроса позволяют утверждать, что безопасность в сфере этнонациональных отношений занимает высокое место в рейтинге различных составляющих национальной безопасности России. Выше по степени значимости эксперты оценили только военную и государственную безопасность страны. При этом следует учитывать, что безопасность в сфере этнонациональных отношений тесно взаимосвязана с военной и государственной безопасностью и оказывает на них значительное влияние. Оценивая источники этнонациональных угроз, большая часть (60%) экспертов полагает, что в настоящее время основные угрозы для России примерно в равной степени исходят из-за рубежа и находятся внутри страны. Меньшая часть (40%) экспертов считает, что они исходят из-за рубежа. При этом никто из опрошенных не поддержал точку зрения, что эти угрозы находятся преимущественно внутри страны. Аналогичные оценки даны экспертами и относительно источников перспективных угроз для Российской Федерации на ближайшие пять – семь лет.
Публичная политика, развитие и институты: логика сопряжения смыслов и “забытые вещи” в новой бытийной реальности
Authors: Михайленок Олег , Назаренко Алексей
Published: January 2020

Отталкиваясь от тем и вопросов, поднимаемых в монографии “Публичная политика. Институты, цифровизация, развитие” под редакцией профессора Л.В. Сморгунова, авторы рассматривают связь феномена политики и ее публичной ипостаси с феноменом развития в новой бытийной реальности. В информационном полицентричном и ризоматичном мире все отчетливее проявляется связь информации, знания, культуры и власти, что приводит к необходимости переосмысления прежних подходов к их концептуализации. Разрушаются привычные социальные структуры, поскольку каждый индивид превращается в производителя истины. Это коренным образом меняет весь социально-политический ландшафт: политические отношения власти начинают пронизывать множество вещей, на первый взгляд имеющих мало общего с политикой. Все чаще возникает вопрос о судьбе устойчивых в прошлом политических структур – институтов, главным из которых остается государство. Каковой может быть роль цифры, которая фактически идентична институтам по своему смысловому наполнению – все упорядочить? Возможно, что все изменит новая информационно-коммуникационная среда, обладающая внутренней свободной логикой и четкими границами, детерминируемая математическими правилами и техническими возможностями современных средств коммуникации, заставляющая обратить внимание на пространство и поток развития. Нужно говорить о новом типе сборки политического пространства, при котором образуются соединения, сохраняющие изначальные агентные импульсы, что делает более правомерным утверждение о том, что не политика для развития, а наоборот – развитие для политики.
Comparing the Camry dynamometer to the Jamar dynamometer for use in healthy Colombian adults
Authors: Díaz Muñoz Gustavo Alfonso , Calvera Millán Sandra Julieth
Published: January 2020

Objective: Hand grip strength can provide an objective index of general upper strength, but hand dynamometer has not been validated for use in Colombia. The objective was to determine the interchangeability between Camry electronic and Jamar hydraulic hand grip dynamometers in a population found on the campus of the Universidad Nacional de Colombia and the elderly living in a community.

Methods: This was a cross-sectional concordance study on 18-88-year-old males and females. Data regarding their demographics, health, and anthropometric variables were collected/measured and the Lin concordance correlation coefficient (CCC) along with Bland-Altman plots were used for evaluating concordance regarding both devices.

Results: One hundred and thirty-three subjects participated in this study (average age 47±20.74 years-old). Right hand (RH) grip strength was 32.15 ± 9.96 kg with the Jamar dynamometer and 29.95 ± 9.18 kg with the Camry device. It is worth highlighting that the Jamar instrument presents higher values than the Camry instrument (p <0.05). CCC was only significant at the population level and for the 40-59-year-old age group. Bland-Altman plots had narrow limits of agreement.

Conclusion: We concluded that the Camry dynamometer could replace the Jamar dynamometer in the 40-59-year-old age group; furthermore, it would be appropriate for medical use in patient monitoring or follow-up due to the close values observed.
DNA adducts in environmental, occupational and life-style studies in human biomonitoring.
Authors: Hemminki K , Grzybowska E , Widłak P , Chorazy M
Published: January 2020

The importance of DNA adducts in carcinogenesis had been discussed. The 32P-postlabelling method was developed as a quantitative technique to measure the level of different DNA adducts including adducts in human DNA. The elevated level of DNA adducts was found in white blood cells in persons exposed environmentally and occupationally to high concentrations of PAHs (polycyclic aromatic hydrocarbons) in the ambient air. Tobacco also generated higher level of DNA adducts both in lymphocytes and laryngeal tissues of smokers. Exposure to styrene has been of interest world-wide because of the very high exposure and persistence of adducts in DNA of lamination workers.
Interactions of rat repetitive sequence MspI8 with nuclear matrix proteins during spermatogenesis.
Authors: Rogoliński J , Widłak P , Rzeszowska-Wolny J
Published: January 2020

Using the Southwestern blot analysis we have studied the interactions between rat repetitive sequence MspI8 and the nuclear matrix proteins of rat testis cells. Starting from 2 weeks the young to adult animals showed differences in type of testis nuclear matrix proteins recognizing the MspI8 sequence. The same sets of nuclear matrix proteins were detected in some fractions enriched in spermatocytes and spermatides and obtained after fractionation of testis cells of adult animals by the velocity sedimentation technique.
Presynaptic phosphoprotein B-50/GAP-43 in neuronal and synaptic plasticity.
Authors: Biewenga J E , Schrama L H , Gispen W H
Published: January 2020

B-50/GAP-43 is a growth-associated phosphoprotein enriched in growth cones and in the presynaptic terminal. The expression of the protein is restricted to the nervous system and is highest in the first week after birth. In adult brain, B-50 is enriched in areas with high plasticity. The regulation of expression of the B-50 gene occurs both at the transcriptional and post-transcriptional level by unknown mechanisms. The gene contains 2 regions displaying promoter activity, the most 3' of which (P2) is the active on in vivo. Expression of B-50 in non-neuronal cells results in filopodial extensions whereas antibodies or antisense oligo's to B-50 prevent neurite outgrowth. The protein is important for neuronal pathfinding. Several post-translational modifications have been described, ADP-ribosylation and palmitoylation in the membrane binding domain, phosphorylation by PKC, casein kinase II and phosphorylase kinase, and dephosphorylation by several phosphatases, among which is calcineurin. Interactions of B-50 have been described with calmodulin, PIP kinase, F-actin, and phospholipids. Recent studies indicate that the phosphorylation state and amount of calmodulin bound to B-50 regulate the rate of transmitter release. Induction of long-term potentiation by high frequency stimulation of hippocampal slices results in an increased state of B-50 phosphorylation. This will increase the amount of free calmodulin in the presynaptic terminal and increase the amount of transmitter released. Although B-50 is involved in seemingly unrelated forms of neuronal plasticity, neurite outgrowth and transmitter release, our unifying hypothesis is that the protein plays an (unknown) essential, modulatory role in membrane expansion.
Purification of IHF-like protein from gram-negative bacteria in one chromatographic step.
Authors: Krawczyk B , Kur J
Published: January 2020

We describe a fast and very efficient method of purification which yields highly purified integration host factor-like proteins in one chromatographic step. IHF-like proteins from Acinetobacter junii or Proteus vulgaris are each an alpha beta heterodimer (subunits of 10 and 11 kDa) similar to the IHF of Escherichia coli when analyzed by polyacrylamide gel electrophoresis. The purified IHF are able to bind to the same ihf sites as IHF of E. coli. The results presented confirm that IHF is conserved during evolution in gram-negative bacteria.
Solubilization and one-step purification of mannosylphosphodolichol synthase from Trichoderma reesei.
Authors: Kruszewska J S , Perlińska-Lenart U , Palamarczyk G
Published: January 2020

Mannosylphosphodolichol synthase (MPD-synthase) (EC 2.4.1.830) catalyzing formation of MPD from GDPMan and dolichylphosphate (PD) has been purified from T. reesei cellular membranes almost to homogeneity. Selective solubilization of the enzyme was followed by one step purification on Phenyl-Sepharose column. SDS/ PAGE of the purified enzyme fraction revealed the presence of a protein band of 31 kDa corresponding to the apparent molecular mass of the MPD-synthase purified from S. cerevisiae [Babczinski, P. et al. (1980) Eur. J. Biochem. 105, 509-515; Haselbeck A. (1989) Eur. J. Biochem. 181, 663-668]. During solubilization, the enzyme was stabilized by the presence of a lipophilic substrate dolichylphosphate and phospholipids as well as by protease inhibitors. The Phenyl-Sepharose purified enzyme had an absolute requirement for dolichylphosphate and was activated by cAMP dependent protein kinase.
Recent progress in oligonucleotide synthesis.
Authors: Pfleiderer W , Matysiak S , Bergmann F , Schnell R
Published: January 2020

New blocking group combinations for the machine-aided oligoribonucleotide synthesis on solid phase material have been developed and tested regarding their general application. An acetal function for 2'-OH protection offers a series of advantages in the synthetic approach but special conditions have to be fulfilled in order to guarantee a selective cleavage of the temporary 5'-OH blocking group such as the dansylethoxycarbonyl or even the acid-labile dimethoxytrityl group in the chain elongation process. The final removal of the 2'-O-acetal function in the partially deblocked oligomer proceeds unexpectedly well under weak acidic conditions due to a supposed intramolecular acid catalysis.
Crystal structures of some acyclonucleosides with antiviral activity and related compounds.
Authors: Birnbaum K B
Published: January 2020

The crystal structure of the acyclonucleoside, 9-[4-hydroxy-2-(hydroxymethyl)-butyl]guanine (2HM-HBG), has been compared with related acyclonucleosides, and that of the acyclonucleotide, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine-3',5'-cyclic phosphate (DHPG-cMP), also with its parent second messenger cGMP and cyclic monophosphate nucleotides. There is considerable conformational flexibility in the acyclic chain of these compounds with several conformations coexisting in the solid state. This flexibility together with the narrow range of the glycosidic torsion angles (from 69 degrees to 94 degrees, with an average of 83(3) degrees for 11 molecules when the aglycon is guanine, and from 92 degrees to 108 degrees with an average of 103(3) degrees for 4 molecules when the aglycon is adenine) may be essential for the antiviral activity of these compounds and their ability to act as substrates. The mechanism of antiviral activity of, 9-[(1,3-dihydroxy-2-propoxy)methyl] guanine-3',5'-cyclic phosphate is different from that of the acyclonucleosides, and is discussed in the light of it being a close structural analogue to the second messenger cGMP.
Expression of small synthetic genes coding for hEGF, human epidermal growth factor, and CPTI II, serine proteinase inhibitor from Cucurbitacea, cloned in a novel expression/secretion vector in Saccharomyces cerevisiae.
Authors: Topczewska J , Rempoła B , Fikus M
Published: January 2020

Efficient synthesis of two small eukaryotic polypeptides of human and plant origin was carried out using a novel expression/secretion yeast vector, pYET. The yield was optimized in respect of the yeast strain, expression cassette construction, promoter regulation and culture conditions. Both cloned genes code for biotechnologically important proteins: human epidermal growth factor and a serine proteinase inhibitor from Cucurbitacea.
Methoxyamine attack on cytosine produces ambivalent base pairing properties of the modified base.
Authors: Gdaniec Z , Sowers L C , Fazakerley G V
Published: January 2020

We report the solution structure of two heptanucleotides each containing a central N4-methoxycytosine, in one case with adenine on the opposite strand and in the other with guanine. For the N4-methoxycytosine-adenine pair only the imino form of the N4-methoxycytosine residue is observed and base pairing is in Watson-Crick geometry. However, rotation of the methoxy group about the N-OCH3 bond is not constrained to a particular orientation although it must be anti to the N3 of N4-methoxycytosine. The slow exchange on a proton NMR time scale between the single strand and double strand forms is attributed to the strong preference of the syn conformation of the OCH3 group in the single strand which inhibits base pair formation. For N4-methoxycytosine base paired with guanosine we observe the N4-methoxycytosine base in the amino form in Watson-Crick geometry and a slow exchange of this species with an imino form base paired in wobble geometry. The amino form is predominant at low temperature whereas the imino form predominates above 40 degrees C. Our results point to preferential replacement of dTTP by N4-methoxycytosine in primer elongation.
Empresarios, innovación y Estado en John K. Galbraith y Mariana Mazzucato
Authors: Centenera Antonio Nogueira
Published: January 2020

John K. Galbraith distinguió entre el sistema planificador dirigido por la gran empresa y el sistema de mercado de los empresarios. El cambio tecnológico y las alteraciones de la vida económica en los países industrializados han hecho inevitable el protagonismo de las grandes corporaciones en conveniencia con el Estado. No obstante, la empresa individual mantuvo relevancia en la obra de Galbraith: las artes y el diseño en sus múltiples facetas siguen siendo el baluarte de la empresa pequeña y una parte expansiva de la vida económica; y casi todo el mundo admira al empresario y no a las multinacionales. Hoy, el debate se ha trasladado al papel innovador del Estado, que percibe riesgos, opera atrevidamente al modo de los emprendedores y cataliza la inversión privada hacia nuevos sectores; como Mariana Mazzucato destaca en su obra.
El enfoque monetario a la Schumpeter: una aplicación a la modelación multiagentes
Authors: Stellian Rémi , Danna-Buitrago Jenny Paola
Published: January 2020

Este trabajo es una reflexión sobre la construcción de modelos multi-agentes únicamente a partir de fenómenos monetarios, conforme al enfoque monetario à la Schumpeter en su forma ideal. Se elaboran principios generales para formalizar una población de agentes que interactúan en forma descentralizada, utilizando solamente fenómenos monetarios; y después se implementan estos principios. El modelo resultante es un sistema dinámico no determinístico, cuyas simulaciones numéricas reproducen hechos estilizados en macroeconomía. El modelo se puede extender para ampliar su poder descriptivo y usarlo para diversas investigaciones económicas.
El gasto público en Colombia: comparaciones internacionales, evolución y estructura
Authors: Melo Becerra Ligia Alba , Ramos Forero Jorge Enrique
Published: January 2020

Este artículo evalúa el tamaño del Estado en un contexto internacional y analiza el comportamiento del gasto público en Colombia durante las dos ú ltimas décadas. Hace una revisión teórica y empírica del gasto público óptimo, y presenta comparaciones internacionales del tamaño del Estado que apoyan la Ley de Wagner: el tamaño del Estado crece al mismo ritmo o a un ritmo superior que el ingreso. También describe la evolución del gasto del gobierno nacional central con base en la clasificación económica tradicional y revisa la evolución del gasto del gobierno por finalidad, haciendo énfasis en el gasto social.
Building a Global Education Collaboration Model Using Experiential Learning: A Fresh Look at Developing Intercultural Competence
Authors: Höß Bernadette , Wasserman Michael , Fisher Sandra
Published: January 2020

Adapting to global business and interpersonal differences is a challenge in both higher education and industry. International education generally seeks to improve student intercultural competence; that is, improving an individual’s ability to work with an international mix of colleagues, customers, and suppliers. Nevertheless, there are many examples where these educational efforts fail. This paper explores virtual team projects, where team members at partner schools in Germany and the U.S. worked together on a joint project, as a mechanism to enhance international education and development of intercultural competence. Using interview and qualitative survey data, we find that these virtual projects offer the opportunity to access different perceptions of problem statements, products and procedures, and apply unique resources and knowledge. We add to the literature by exploring both tools and processes to address improved virtual team collaboration through the lens of intercultural competence. Currently, there are many tools which allow cost-effective communication and document exchange (e.g. Slack, Google Drive, Skype) and facilitate virtual projects. We explore several challenges: the geographical distance (e.g. time zones) combined with cultural distance (e.g. different norms, values, and language) make it hard to establish an intensive, trusting work environment. As global networking increases, universities can better prepare students using cross-cultural project-based learning – a process – that involve university partnerships beyond reciprocal on-campus residencies. We offer a process model and four experiential project-based learning ideas designed to develop cultural competence and virtual team skills, and that address challenges such as differences in academic calendars, student work styles, time zones, and educational norms.