bluuebunny/crossref_metadata_2025 huggingface dataset:
Wireless Play Music Beep Sensor to Assist in Music Fountain Control
Authors: Wang Qian
Published: August 2022

Musical water landscape combines landscape design with audiovisual art and is loved by the general public. However, the performance control form of musical water landscape generally adopts the manual offline preprogramming method, which needs to use the human subject’s consciousness to perceive the style, emotion, and other advanced features of the music first and then choreographs the corresponding landscape performance, which is a high-cost design form and low usage rate of the landscape and is not conducive to the expansion of the music library. In this paper, we design and implement a musical water landscape simulation system using OpenGL and 3Dmax technology in combination with wireless music buzzer sensors, extract and analyze the music features based on this system, and study the system control of musical water landscape. Open GL particle system technology is used to realize the dynamic simulation of weather and fountain inside the landscape and improve the drawing scheme from both modeling and rendering aspects. For the fountain, the physical model and the wireless music beep sensor are combined to design a variety of water type actions for a single spout, and the parameter interface to control the water type changes is reserved. We propose a style recognition method based on CRNN and residual network, which has a higher accuracy rate compared with the existing methods; we use the DP algorithm to segment the pitch sequence of the music to reduce the redundancy of information and improve the calculation speed of the system.
[Retracted] Analysis of Sino‐Russian Media Cooperation and the Construction of International Online Public Opinion Discourse under the Dual Influence of Ecological and Online Environments
Authors: Zhang Juxi , Ma Chongyu
Published: August 2022

In the context of traditional media, the media can dominate the topic and composition of public opinion, but in the context of the convergence of online media, the dominance of public opinion has gradually evolved from the direction of the coexistence of single items and pluralism, especially from the international level. In other words, the construction of the comprehensive strategic writing partnership between China and Russia in the new era has given a new orientation and connotation to the bilateral relations and cooperation in the new era. In the face of an increasingly complex international public opinion environment, media cooperation between China and Russia is crucial. Therefore, based on an in‐depth analysis of the construction of the discourse power of international public opinion under the dual influence of the ecological environment and the network environment, the construction of the discourse power of international public opinion is discussed from the aspects of the construction of discourse objects, the construction of the main body, and the enrichment of the content of international communication.
Application of Big Data Clustering and Visual Communication in Business Website Interface Design
Authors: Qu Xuan
Published: August 2022

The interface design of commercial websites is used in this paper to demonstrate the application of big data clustering and visual communication technologies. This paper presents the new requirements of user integration, emotion, and personalization by analyzing the broad influence of big data clustering technology and visual communication on the design concept and design method of commercial website interface design. Then, focusing on the information of visual graphic elements in web interface design and discussing how structures, images, words, emotions, and other elements can convey information more effectively through graphic means, the information in the web interface is creatively divided into two types: implicit and explicit. The database for the interface interaction system is built as part of this paper, which also uses fuzzy clustering to organize the data from the interface retrieval database and the hierarchical structure design method of process constraints to carry out interface information interaction and big data fusion processing. According to experiments, this algorithm’s accuracy can reach 95.75%, which is about 11% higher than that of other approaches. This study can offer a workable design strategy for a business website’s user interface.
[Retracted] Awareness of Medical Students toward Circadian Rhythm and Sleep Disorder Based on Biomedical Diagnosis
Authors: Alanazi Asma , Alhawas Haifa , Aldossari Munirah , Almutairi Dana , Almatroudi Dana , Alenazi Afnan , Almadhi Leen , Albalawi Maram
Published: August 2022

Background. Sleep disorders affect an individual’s mental and physical health and vice versa. Sleep medicine is underrecognized as a specialty; therefore, many sleep disorders go undiagnosed. This study is aimed at assessing the knowledge of medical students toward circadian neuroscience and sleep disorder based on biomedical diagnosis. Methods. This cross‐sectional study was conducted in both male and female medical colleges from the third to the sixth year. A self‐administered structured questionnaire consisting of sociodemographic data and the Assessment of Sleep Knowledge in Medical Education (ASKME) survey assessed the students’ general knowledge and attitude towards sleep disorder and sleep medicine. Chi‐square/Fisher exact tests were used to analyse the participants’ knowledge level toward specific sociodemographic data. Also, for two‐level continuous variables, the Wilcoxon two‐sample test was used. Results. The total number of participants was 296, with 154 female and 142 male participants. The prevalence of inadequate knowledge was considerable with 96.62% of students, compared to adequate knowledge with only 3.38%. The students’ attitude to sleep medicine was negative 14.53% and positive among 85.47%. We found that gender was significantly associated with attitude with a p value = 0.0057. The specific interest in sleep medicine had a significant association with knowledge and attitude, p value of 0.0522 and 0.0059, respectively. Conclusion. This study concluded that medical students possess inadequate knowledge regarding sleep medicine, yet they have a positive attitude towards it.
A Retrospective Analysis of Internet-Based Sharing Nursing Service Appointment Data
Authors: Fan Yuchen , Ma Yuezhen , Zhang Yong , Sun Changjian
Published: August 2022

Aims. To investigate the historical data of the “Internet+ Nursing” service platform and provide a theoretical basis to optimize the “Internet+ Nursing” service model by analyzing a population in need of nursing care services, service prices, services in demand, willingness to place orders, and feedback on use. Methods. A retrospective analysis of data related to home care services on the “Jiuzhou Nursing Care” platform from April 2020 to August 2021, a total of 279 person-times, relevant information about the research subjects, and the status of home care services was conducted. SPSS 24.0 software was used for data analyses, such as calculating frequencies and percentages and conducting chi-square tests. Results. The “Jiuzhou Online Nurse” primarily serves elderly patients, and the majority of these patients have lost their ability to care for themselves. The average cost of nursing services was ¥183.45, and the unit cost of services had no effect on the number of service items. This particular internet-based home nursing service has a high level of satisfaction. Patients aged 60 to 74 have the highest number of Internet-based home care service orders (

χ

2

=
11.791

,

P
<
0.05

). Patients who reuse the platform are more willing to assign people to provide services (

χ

2

=
238.078

,

P
<
0.05

). Patients who were unable to care for themselves had a higher rate of repeat order (

χ

2

=
10.877

,

P
<
0.05

). Conclusion. The “Internet+ Nursing” service platform specifically meets the individual needs of elderly patients, provides them with home nursing services, and improves local medical treatment and door-to-door services. This platform also provides convenience for elderly individuals who cannot care for themselves so that they can receive prompt treatment and assistance to improve their quality of life.
Modeling and Simulation of Ultra-Wideband Communication Receiver Based on Balanced Sampling and Integrating Circuit
Authors: Wang Zhiqi , Huang Zhonghua , Hao Shijun , Guo Zhe , Wu Kaiwei
Published: August 2022

In order to solve the problem of extracting signals from impulse radio ultra-wideband (IR-UWB) receivers in a low signal-to-noise ratio (SNR) environment, this paper uses circuit transient analysis to establish a mathematical model of an ultra-wideband wireless communication receiver based on a balanced sampling and integration circuit (BSIC). The effect of receiver circuit component parameters on the output signal is simulated and tested, and the optimization of circuit component parameters for UWB wireless communication receivers is achieved. The sampling capacitance in the receiver circuit ranges from 1 pF to 6 pF, depending on the 200 ps pulse width. The output signal amplitude increases as the sampling capacitance increases. The range of integral capacitance is from 2.5 pF to 25 pF, which is based on a 100 ns interval between two pulses. The output signal amplitude decreases as the integration capacitance increases and the signal waveform becomes better as the integration capacitance increases. The effect of SNR from 0 to −30 dB on the receiver output is simulated, and the results show that the Bit Error Ratio (BER) of the receiver is less than 10−3 when the SNR is greater than −15 dB. The simulation and test results show that the model developed in this paper is useful as a guide for optimizing the receiver parameters at low SNR.
The Feature Recognition of Motor Noise Based on the Improved EEMD Model
Authors: Liao Qing , Li Long , Luo Jiaqi
Published: August 2022

The noise generated by the machine is closely related to the running state of the machine, so the product can be effectively detected by analyzing the noise signal. The noise identification and control methods based on the EEMD model are widely used in motor noise control. However, the EEMD only considers the influence of noise amplitude on the decomposition results, and the added white noise cannot be completely neutralized. In this paper, an improved EEMD method is proposed by analyzing the influence of the maximum frequency on the decomposition results, in which the noise with different maximum frequency and amplitude is added to decompose the signal, and the decomposition effect is judged by the orthogonality coefficient of the decomposition result. Finally, the simulation signal and the measured signal are compared and analyzed, and the results show that the improved EEMD method has some advantages over the original method in suppressing mode confusion and fault diagnosis.
Factors Associated with Implanon Discontinuation among Women of Reproductive Age in Ethiopia: A Systematic Review and Meta-Analysis
Authors: Tefera Zenebe , Assefaw Mandefro , Ayalew Sindu , Gashaw Wondimnew , Abate Mengistu , Temesgen Kibir , Abebaw Nigusie , Yalew Melaku
Published: August 2022

Background. Implanon is a long-acting contraceptive method that is extremely effective in preventing pregnancy with a clinical failure rate of less than 1%. Despite these, the rate of Implanon discontinuation is a common problem in various societies and exposes women to unwanted conception and its consequences. Objective. The current study sought to find and consolidate relevant literature on Implanon discontinuation and associated factors in Ethiopia. Methods. Medline, PubMed, Cochrane Library, EMBASE, and Google Scholar databases were systematically searched for studies published in English before December 2021. The included studies were critically appraised using the JBI instrument for observational studies. STATA version 16 was used for analysis. The presence of statistical heterogeneity was checked using Cochran’s

Q

test, and its level was quantified using

I

2

statistics. A pooled estimate of the proportion of outcome variables was calculated. To measure the effect size, pooled odds ratios with 95% CI were computed. Results. The pooled prevalence of Implanon discontinuation in Ethiopia was 32.89%, 95% CI: 24.11%, 41.66%. Experiencing side effects (

OR
=
2.52

, 95% CI 1.75, 3.65), having no children (

OR
=
1.69

, 95% CI 1.15, 2.47), not having received preinsertion counselling (

OR
=
1.65

, 95% CI 1.36, 2.00), having no postinsertion appointment (

OR
=
2.97

, 95% CI 2.10, 4.21), and not satisfied with the service (

OR
=
2.72

, 95% CI 2.47, 5.59) were significantly associated with Implanon discontinuation. Conclusion. The pooled prevalence of Implanon discontinuation in Ethiopia was high. Experiencing side effects, having no child, not receiving preinsertion counselling, having no follow-up appointment, and not being satisfied with the service were significantly associated with Implanon discontinuation. Therefore, healthcare providers should offer preinsertion counselling in accordance with national family planning guidelines, emphasizing the method’s advantages and side effects.
Accidental Insertion of a Broken Needle into the Pterygoid Mandibular Space during Inferior Alveolar Nerve Block: A Case Report
Authors: Terada Kazuhiro , Yamagata Kenji , Uchida Fumihiko , Fukuzawa Satoshi , Ishibashi-Kanno Naomi , Bukawa Hiroki
Published: August 2022

The incidence of needle breakage is estimated to be 0.000007%, and most needle breaks occur during inferior alveolar nerve block (IANB) administration and are localized to the pterygomandibular space. Although immediate surgical intervention is recommended for the removal of the fracture needles, intraoperative localization of a broken injection needle fragment can be challenging. Here, we present the case of a 36-year-old woman who underwent dental extraction of the left lower wisdom tooth under local anesthesia at a private office. At that time, a disposable 33G needle was broken and accidentally inserted into the pterygomandibular space during IANB. A broken injection needle was presented at the base of the left coronoid process of the mandible on computed tomography (CT). We successfully removed the broken injection needle using fluoroscopy and assisted endoscopy under general anesthesia.
Treatment of Comprehensive Wastewater from Chemical and Pharmaceutical Parks by Fly Ash-Coated Iron Electrode Electrocoagulation
Authors: Zhu Huajing , Chen Zeli
Published: August 2022

With the rapid development of the economic system and the continuous development of industry, environmental pollution is becoming more and more important, so wastewater treatment urgently needs to be strengthened. This article uses fly ash-coated iron electrode electrocoagulation method to carry out experimental tests on the treatment of comprehensive wastewater from chemical and pharmaceutical parks. Fly ash is used as a raw material to prepare a shaped adsorbent; in order to analyze whether the adsorbent has many potential applications in actual wastewater treatment and use. The experiment research of iron electrode electrocoagulation was carried out on actual groundwater, aiming to provide data and theoretical support for the utilization of fly ash and the optimization of comprehensive wastewater treatment technology. The article mainly conducts related research on title distribution, firstly the physical and chemical properties of fly ash, and secondly, discusses the related structure of electrocoagulation method, and solves the problem of comprehensive wastewater based on the combination of the two solving issues. Aware of the importance of sewage treatment and the characteristics of related treatment methods such as adsorption, membrane separation technology, and ion exchange, the advantages of these methods are also used for reference in subsequent experiments to achieve the purpose of reliable experimental results. The experimental results show that the effect of sewage treatment with fly ash with different average diameter particles is obvious. Among them, the maximum value of vibration grinding ash before and after application increased from 5.62 to 8.31, and the maximum removal rate is also 8.31; the removal effect is significant. It can be seen that the fly ash-coated iron electrode electrocoagulation method can have a great effect on the treatment of comprehensive wastewater in the chemical and pharmaceutical park.
[Retracted] Research on the Expression Level of Matrin‐Type Zinc Finger Protein 4 Gene in T Cells of Thyroid Carcinoma Tissue
Authors: Zhang Qian , Song Yingchun , Chen Shengguang , Lv Zhongwei
Published: August 2022

In order to analyze the expression level of zinc finger matrin‐type protein 4 (ZMAT4) gene in T cells of thyroid carcinoma (TC) tissue and its clinical significance to prognosis of patients based on bioinformatics and reverse transcription polymerase chain reaction (RT‐PCR), 389 TC patients with ZMAT4 gene and its corresponding survival and prognosis are searched by the Cancer Genome Atlas database. The expression of ZMAT4 gene is compared between normal thyroid tissue and TC tissue by RT‐PCR. The relationship between ZMAT4 expression levels and clinicopathological parameters and baseline data is analyzed. The experimental results show that the low expression of ZMAT4 gene has an important relationship with the development of thyroid cancer, and real‐time monitoring of ZMAT4 gene in TC patients can effectively evaluate the prognosis of patients.
A Study on the Impact of Perioperative Pain Care Management on Pain, Comfort, and Defecation of Patients in Anorectal Surgery
Authors: Liao Yimei , Jiang Jing , Luo Jin , Du Wenwu , Zhao Weiwei , Zhang Yafeng
Published: August 2022

Purpose. The aim of the study is to explore the impact of perioperative pain care management on patients’ pain, comfort, and defecation in anorectal surgery. Methods. From January to December 2021, 126 patients who underwent anorectal surgery in our department were selected for the study and were randomly divided into a study group and a control group of 63 patients each after consent was obtained from the patients. The control group was given the usual care protocol and the study group was given the perioperative pain care management on top of the usual care. The two groups of patients were compared in terms of postoperative anal pain rating, comfort score, time to first bowel movement and time spent in bowel movement, the Pittsburgh sleep quality index (PSQI) scores at night, related complications, and satisfaction with care. Results. ① Postoperative anal pain was less severe in the study group than in the control group (

P
<
0.05

). ② Postoperative comfort scores were higher in the study group than in the control group (

P
<
0.05

). ③ The time to first bowel movement and its duration after surgery were shorter in the study group than in the control group (

P
<
0.05

). ④ Patients in the study group had lower postoperative night-time PSQI scores than the control group (

P
<
0.05

). ⑤ Patients in the study group had a lower rate of postoperative complications than the control group (

P
<
0.05

). ⑥ Patients in the study group had higher postoperative care satisfaction scores than the control group (

P
<
0.05

). Conclusion. The application of perioperative pain care management to patients undergoing anorectal surgery plays an important role in reducing anal pain, improving treatment comfort, and relieving difficult defecation symptoms, with significant improvement in postoperative sleep quality and reduction in complications. It is worthy of clinical reference and promotion.
Water Resources Carrying Capacity and Circular Economy Based on Fuzzy Multilayer Algorithm
Authors: Ai Liangyou
Published: August 2022

By combining the relevant theoretical foundations such as fuzzy algorithm and water resources environmental management, and selecting the actual water resources integration data, this paper establishes an index system to investigate the carrying capacity of the water environment in this area. Through the study and application of the comprehensive multilevel fuzzy evaluation model, based on scenario analysis, the current situation of water resources environmental management and the temporal and spatial variation characteristics of water resources in the study area in recent years were evaluated. In order to observe the differences more accurately in the spatial structure of water use in the study area through information entropy, ArcGIS IS images were drawn according to the calculation results of the urban degree balance in the study area. In the development of circular economy, the information center plays an important role in the industrial ecosystem, which is the basis for the recycling of materials, energy, and water. By building a unique data platform, it can help companies understand the latest status of logistics, energy, and waste recycling in the park and can make adaptive adjustments to the above conditions, to achieve the sustainable development of the overall industrial chain.
Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages
Authors: Murgaski Aleksandar , Kiss Máté , Van Damme Helena , Kancheva Daliya , Vanmeerbeek Isaure , Keirsse Jiri , Hadadi Eva , Brughmans Jan , Arnouk Sana M. , Hamouda Ahmed E.I. , Debraekeleer Ayla , Bosteels Victor , Elkrim Yvon , Boon Louis , Hoves Sabine , Vandamme Niels , Deschoemaeker Sofie , Janssens Sophie , Garg Abhishek D. , Vande Velde Greetje , Schmittnaegel Martina , Ries Carola H. , Laoui Damya
Published: August 2022

Agonistic αCD40 therapy has been shown to inhibit cancer progression in only a fraction of patients. Understanding the cancer cell–intrinsic and microenvironmental determinants of αCD40 therapy response is therefore crucial to identify responsive patient populations and to design efficient combinatorial treatments. Here, we show that the therapeutic efficacy of αCD40 in subcutaneous melanoma relies on preexisting, type 1 classical dendritic cell (cDC1)–primed CD8+ T cells. However, after administration of αCD40, cDC1s were dispensable for antitumor efficacy. Instead, the abundance of activated cDCs, potentially derived from cDC2 cells, increased and further activated antitumor CD8+ T cells. Hence, distinct cDC subsets contributed to the induction of αCD40 responses. In contrast, lung carcinomas, characterized by a high abundance of macrophages, were resistant to αCD40 therapy. Combining αCD40 therapy with macrophage depletion led to tumor growth inhibition only in the presence of strong neoantigens. Accordingly, treatment with immunogenic cell death–inducing chemotherapy sensitized lung tumors to αCD40 therapy in subcutaneous and orthotopic settings. These insights into the microenvironmental regulators of response to αCD40 suggest that different tumor types would benefit from different combinations of therapies to optimize the clinical application of CD40 agonists.

Significance:

This work highlights the temporal roles of different dendritic cell subsets in promoting CD8+ T-cell–driven responses to CD40 agonist therapy in cancer.
Ancient Human Endogenous Retroviruses Contribute to Genetic Evolution and Regulate Cancer Cell Type–Specific Gene Expression
Authors: Chen Mingyue , Jia Lei , Zheng Xiaofeng , Han Mingshu , Li Lin , Zhang Lei
Published: August 2022

Human endogenous retroviruses (HERV), a type of transposable elements (TE), play crucial roles in human placental morphogenesis, immune response, and cancer progression. Emerging evidence suggests that TEs have been a rich source of regulatory elements in the human genome, but little is known about the global impact of HERVs on transcriptional networks in cancer. Using genome-wide approaches, we show that HERVs are composed primarily of three ancient superfamilies: ERVL-MaLR, ERVL, and ERV1. This analysis suggests that the integration of exonic, intronic, and intergenic HERVs, as well as human or Hominidae gene-specific HERVs, contributes to human genomic innovation. HERVs exonized in genes are located mainly in the 3′ untranslated region (UTR) or 3′ end and participate in basic biological processes. Active HERVs are located mainly in intronic and intergenic regions and tend to function as enhancers and contribute to cancer cell type–specific gene expression. More importantly, HERVs may also define chromatin topologically associating domain (TAD) and loop boundaries in a cell type–specific manner. Taken together, these findings reveal that ancient HERV elements are a source of diverse regulatory sequences, including 3′ UTRs, 5′ UTRs, promoters, and enhancers, and they contribute to genetic innovation and cancer cell type–specific gene expression, highlighting the previously underestimated importance of these elements.

Significance:

Genome-wide analyses show that human endogenous retroviruses mediate cancer cell type–specific gene expression, epigenetic modification, and 3D chromatin architecture, elucidating the relationship between HERVs and diverse cancers.
Inhibition of Melanoma Cell–Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis
Authors: Schatton Tobias , Itoh Yuta , Martins Christina , Rasbach Erik , Singh Praveen , Silva Mariana , Mucciarone Kyla , Heppt Markus V. , Geddes-Sweeney Jenna , Stewart Kate , Brandenburg Anne , Liang Jennifer , Dimitroff Charles J. , Mihm Martin C. , Landsberg Jennifer , Schlapbach Christoph , Lian Christine G. , Murphy George F. , Kupper Thomas S. , Ramsey Matthew R. , Barthel Steven R.
Published: August 2022

T-cell immunoglobulin mucin family member 3 (Tim-3) is an immune checkpoint receptor that dampens effector functions and causes terminal exhaustion of cytotoxic T cells. Tim-3 inhibitors are under investigation in immuno-oncology (IO) trials, because blockade of T-cell-Tim-3 enhances antitumor immunity. Here, we identify an additional role for Tim-3 as a growth-suppressive receptor intrinsic to melanoma cells. Inhibition of melanoma cell-Tim-3 promoted tumor growth in both immunocompetent and immunocompromised mice, while melanoma-specific Tim-3 overexpression attenuated tumorigenesis. Ab-mediated Tim-3 blockade inhibited growth of immunogenic murine melanomas in T-cell–competent hosts, consistent with established antitumor effects of T-cell-Tim-3 inhibition. In contrast, Tim-3 Ab administration stimulated tumorigenesis of both highly and lesser immunogenic murine and human melanomas in T-cell–deficient mice, confirming growth-promoting effects of melanoma-Tim-3 antagonism. Melanoma-Tim-3 activation suppressed, while its blockade enhanced, phosphorylation of pro-proliferative downstream MAPK signaling mediators. Finally, pharmacologic MAPK inhibition reversed unwanted Tim-3 Ab-mediated tumorigenesis in T-cell–deficient mice and enhanced desired antitumor activity of Tim-3 interference in T-cell–competent hosts. These results identify melanoma-Tim-3 blockade as a mechanism that antagonizes T-cell-Tim-3–directed IO therapeutic efficacy. They further reveal MAPK targeting as a combination strategy for circumventing adverse consequences of unintended melanoma-Tim-3 inhibition.

Significance:

Tim-3 is a growth-suppressive receptor intrinsic to melanoma cells, the blockade of which promotes MAPK-dependent tumorigenesis and thus counteracts antitumor activity of T-cell–directed Tim-3 inhibition.
Cytogenetic Mapping of Cattle BAC Probes for the Hypothetical Ancestral Karyotype of the Family Cervidae
Authors: Bernegossi Agda Maria , Vozdova Miluse , Cernohorska Halina , Kubickova Svatava , Galindo David Javier , Kadlcikova Dita , Rubes Jiri , Duarte José Maurício Barbanti
Published: August 2022

Cervids are characterized by their greatest karyotypic diversity among mammals. A great diversity of chromosome numbers in notably similar morphological groups leads to the existence of several complexes of cryptic species and taxonomic uncertainties. Some deer lineages, such as those of Neotropical deer, stand out for a rapid chromosomal reorganization and intraspecific chromosome polymorphisms, which have not been properly explored yet. For that reason, we contribute to the study of deer karyotype diversity and taxonomy by producing and characterizing new molecular cytogenetic markers for the gray brocket deer (Subulo gouazoubira), a deer species that retained the hypothetical ancestral karyotype of Cervidae. We used bacterial artificial chromosome (BAC) clones derived from the cattle genome (Bos taurus) as markers, which were hybridized on S. gouazoubira metaphase chromosomes. In total, we mapped 108 markers, encompassing all gray brocket deer chromosomes, except the Y chromosome. The detailed analysis of fluorescent in situ hybridization results showed 6 fissions and 1 fusion as interchromosomal rearrangements that have separated cattle and gray brocket deer karyotypes. Each group of BAC probes derived from bovine chromosome pairs 1, 2, 5, 6, 8, and 9 showed hybridization signals on 2 different chromosomes, while pairs 28 and 26 are fused in tandem in a single acrocentric chromosome in S. gouazoubira. Furthermore, the BAC markers detected the occurrence of intrachromosomal rearrangements in the S. gouazoubira chromosomes homologous to pair 1 and the X chromosome of cattle. We present a karyotypic map of the 108 new markers, which will be of great importance for future karyotypic evolution studies in cervids and, consequently, help in their conservation and taxonomy resolution.
Safety Signal between Azacitidine and Pericarditis
Authors: Chu Brandon , Venkatakrishnan Ajit , Aggarwal Pushkar
Published: August 2022

Background: Drug-induced pericarditis is an important cause of pericarditis and if unnoticed and unmanaged can lead to constrictive pericarditis, pericardial effusion, and cardiac tamponade. Objective: The objective of this analysis was to determine if a significant signal exists between azacitidine use and pericarditis. Methods: A pharmacovigilance analysis was performed using the FDA Adverse Event Database. Results: 48 reports of azacitidine-induced pericarditis with azacitidine as the suspect drug were identified. The most common indications for azacitidine use in the adverse event reports were myelodysplastic syndrome (48%) and acute myelogenous leukemia (27%). Physicians reported 44% of the azacitidine-induced pericarditis reports, while other health professional reported 52% of the reports. The disproportionality analysis showed a proportional reporting ratio of 5.0, χ2 of 149.8, reporting odds ratio of 5.0, and IC025 of 1.8. Literature review found 3 case reports of azacitidine-induced pericarditis. Conclusion: The signal between azacitidine and pericarditis was found to be statistically significant. Clinicians should be aware of the possible risk of pericarditis when prescribing azacitidine. If there is suspicion for azacitidine-induced pericarditis, clinicians should consider discontinuation of azacitidine to improve patient’s symptoms and reduce the likelihood of the development of constrictive pericarditis, pericardial effusion, and cardiac tamponade.
Juvenicidio y prácticas de resistencia/ reexistencia en Medellín (Colombia) y Mendoza (Argentina)
Authors: Seca María Victoria , Mancera-Panza Lorena Cecilia
Published: August 2022

(analítico)Artículo resultado de una reflexión conjunta realizada en dos ciudades, una de Argentina y una de Colombia. El estudio cualitativo sobre cómo y por qué surgieron cuatro espacios de participación juvenil permitió encontrar en palabras de los y las jóvenes de sectores populares la expresión de experiencias cargadas de vulnerabilidad social. Con el objetivo de construir miradas regionales a partir de investigaciones situadas, las autoras articularon sus hallazgos en torno al estudio de procesos comunitarios juveniles surgidos como respuestas al juvenicidio y la precariedad de la vida en la comuna 13, Medellín (Colombia) y dos barrios populares de Mendoza (Argentina). Estos espacios vitales para los y las jóvenes construyen identidades colectivas en clave territorial, generacional y de clase, y proponen nuevos sentidos que impugnan aquellos que circulan desde visiones hegemónicas.
Palabras clave: Juventudes; violencia; resistencia a la opresión; movimiento juvenil.
Escritos do genocídio: A fome e Famintos à luz dos eventos recentes
Authors: Castaldi João Luiz Xavier
Published: August 2022

Faz-se aqui uma reflexão sobre como os eventos ocorridos entre 2020 e 2021 forçaram um novo olhar sobre nosso estudo comparativo – entre os romances A fome, de 1890, do brasileiro Rodolfo Teófilo, e Famintos (1962), do cabo-verdiano Luís Romano – que se iniciou em 2019. O retrato literário, mas também documental, dos genocídios engendrados pela fome, pela doença e pela apatia (às vezes, sabotagem) do poder público ganhou assim uma nova camada em meio à pandemia que vivenciamos.
Por uma literatura não confinada: a rede virtual como aliada da criação literária
Authors: Monteiro Felipe de Souza
Published: August 2022

Neste artigo traremos um panorama de como importantes teóricos de nosso tempo — como Franco Berardi e Jonathan Crary — enxergam o corpo na contemporaneidade, destacando a grande influência de aparatos técnicos existente neste contexto. Mostraremos ainda como o quadro tecido pelos autores se exacerbou durante o período de isolamento social engendrado pela pandemia de Covid-19. Diante disso, mostraremos como os autores e ensaístas Agustín Fernández Mallo e Kenneth Goldsmith veem a internet como aliada da criação literária.
Fragmentos e rupturas nos contos de Samuel Rawet
Authors: Pereira Henrique Moura
Published: August 2022

Este artigo busca refletir, sob a perspectiva hermenêutica, a produção literária em contos do escritor Samuel Rawet, compilada em Contos e novelas reunidos, objetiva-se apontar em que medida o autor realiza uma poética baseada em fragmentos e rupturas. Baseia-se a análise na concepção de “conto”, tal como Cortázar (2006), “narrador”, segundo Arrigucci Jr. (1998), “personagem”, como pensado por Candido (2014) e “dasein”, tal como Heidegger (2012).
Excurso sobre tempos cerrados
Authors: Kaczorowski Jacqueline
Published: August 2022

Se grande parte da obra de José Luandino Vieira foi escrita em situação de confinamento, pouco se assemelha ao tipo de isolamento requerido pela pandemia que nos assola. A prisão, condição muito mais radical, confiscou 12 anos da vida do escritor que passou, a partir de então, a recorrer à própria memória para “substituir a vida” enquanto a tinha “hipotecada por vários anos” (VIEIRA, 2015, p. 09). Em Papéis da Prisão, reunião de parte do material produzido neste contexto, é possível encontrar, no entanto, passagens que podem encontrar eco no presente ao refletir acerca das modificações que a relação com o tempo sofre quando a relação com o espaço é forçosamente modificada.
Desdobramentos da pandemia da COVID-19 e o radar da produção literária brasileira contemporânea
Authors: Brandileone Ana Paula Franco Nobile
Published: August 2022

Este artigo faz parte de um projeto maior de pesquisa intitulado “A literatura brasileira contemporânea em tempos de pandemia”, cujo objetivo central é mapear e analisar a produção literária brasileira contemporânea, que tome como objeto de representação aspectos da vida humana relativos à pandemia do Coronavírus. Nesse contexto, a proposta deste artigo objetiva evidenciar, de um lado, o impacto e os desafios gerados pela pandemia, que atingiu a todos, sem distinção e, de outro, desvelar a fertilidade de autores e de obras que buscam traduzir a experiência humana em tempos de pandemia.
Editorial
Authors: Jordão Guilherme Alves , Silva Juliana Kohari da , Magalhães Lucas Breda , Aguilar Luiza Helena Damiani , Bento Oluwa Seyi Salles , Cruz Vitória Ellen Oliveira da
Published: August 2022

Editorial da edição 27
Análise comparativa de duas traduções da obra Yerma para o português
Authors: Silva Vanessa Roma da , Ferreira Élida Paulina
Published: August 2022

Com base nas reflexões de Jacques Derrida sobre a tradução (1998, 1999, 2001, 2006), analisamos duas traduções para o português brasileiro, assinadas por Cecília Meireles (1963) e Marcus Mota (2000), da obra dramática Yerma, de Federico García Lorca. Buscamos fazer uma análise comparativa dessas traduções, problematizando as possíveis semelhanças e/ou diferenças entre elas, com ênfase nas escolhas tradutórias no âmbito do nível de linguagem e seus impactos no tom dramático e poético do texto, tais como: supressão ou acréscimo textual e seus efeitos; nomes e designações dos personagens; e as escolhas tradutórias relativas à seleção vocabular de estruturas gramaticais e sintático-semânticas e seus efeitos. Com a análise comparativa, comprovamos que as escolhas tradutórias feitas por Meireles (1963) e por Mota (2000) evidenciam transformações nos textos traduzidos e constroem imagens diferentes da obra de Lorca.
Réduction des constructions du complément infinitif des verbes marquant le déroulement de l’action, des verbes exprimant le refus et des verbes de parole
Authors: Habachi Samah
Published: August 2022

La plupart des variations de constructions qui touchent l’emploi d’un grand nombre de verbes au XVIIe siècle (par exemple, essayer à Inf/essayer de Inf) évoluent vers la fixation dans un seul schéma de complément. Cette étude diachronique examine notamment la régression des variations des verbes marquant le déroulement de l’action, des verbes exprimant le refus et des verbes de parole. Il s’agit de voir à quel point les verbes ont tendance à se stabiliser dans la même construction des verbes de sens proche. Par ailleurs, il est question de rechercher les facteurs historiques et syntaxiques qui favorisent la réduction du nombre des schémas.
A nação e a Europa nos livros didáticos de história franceses e alemães. Uma análise do discurso contrastiva
Authors: Von Münchow Patricia , Sardá Daniela Nienkötter , Santos Guilherme Soares dos
Published: August 2022

Este artigo trata da construção do “Si” e do “Outro” europeu nos capítulos que abordam a Primeira Guerra Mundial, em onze livros didáticos recentes de história franceses e alemães. No âmbito da “análise do discurso contrastiva”, e embasando o estudo em um inventário de procedimentos discursivos (explícitos ou não), mostra-se que os livros franceses se esforçam em construir um Si europeu apagando os beligerantes do discurso, mas sem consegui-lo totalmente, e que o Outro — sempre alemão — surge regularmente e é então construído como o único ator da guerra. O Si nos livros didáticos alemães é, ainda que não explicitamente, a Alemanha: a construção de uma comunidade nacional efetua-se inteiramente no não dito e, assim, na evidência. Ela é contrabalançada por um esforço constante de mudança de perspectiva, na qual o aluno deve aprender a colocar-se no lugar do Outro, que é, no caso, o não alemão.
Entrevista com Sheila Grillo: Análise de Discursos Comparativa no Brasil
Authors: Grillo Sheila Vieira de Camargo , Barbosa Vanessa Fonseca
Published: August 2022

No dia 12 do mês de abril de 2022, Sheila Vieira de Camargo Grillo, professora livre-docente e pesquisadora da FFLCH/USP, recebeu-nos, gentilmente, em sua casa, para a realização desta entrevista, por meio da qual pudemos ouvir a autora a respeito de alguns pontos essenciais de uma nova abordagem de investigação científica no Brasil, a Análise de Discursos Comparativa ou Análise do Discurso Contrastiva (denominação adotada na França, país de origem da abordagem). A professora Sheila Grillo, a partir das perguntas que lhe fizemos, discorreu, dentre outros aspectos, sobre o surgimento dos princípios epistemológicos da abordagem em nosso país, citou alguns de seus importantes eventos ocorridos até o presente momento, bem como nos falou acerca da importância de trabalhos desenvolvidos entre ela e demais pesquisadores do Grupo de Pesquisa Diálogo (CNPq/USP) com professores e pesquisadores do grupo CLESTHIA – axe sens et discours, da Université Sorbonne Nouvelle, Paris 3. Desse modo, aproveitamos o espaço para agradecer à entrevistada pelo acolhimento e pelas informações disponibilizadas. Convidamos o leitor da Linha D’Água a apreciar o resultado deste trabalho.
Catalogação dos trabalhos de conclusão de curso na Licenciatura em Música da UFRR
Authors: Friesen Rafael Ricardo , Baptaglin Leila Adriana
Published: August 2022

O presente artigo analisou os trabalhos monográficos de conclusão de curso originados na licenciatura em Música da Universidade Federal de Roraima, desde a criação do curso em 2013 até o término do primeiro semestre de 2021, em seu calendário civil. Somente a partir da década de 1980 tem-se uma escola de música local e, a partir daí, uma tentativa de instalação de mais instituições educacionais voltadas à música. O curso de licenciatura em música foi criado em 2013 com o intuito de atender a essas demandas de profissionais qualificados para a educação musical local. Dessa forma, tem-se que averiguar os trabalhos monográficos aí surgidos serve para levantar informações a respeito de particularidades regionais. Foram encontradas temáticas que perpassam os conteúdos abordados no curso em questão, além de ter havido adesão às pesquisas realizadas pelo corpo docente.
Modernismo e influência dos Balés Russos no balé Uirapuru (1917) de Villa-Lobos e Volúsia
Authors: Schroeder Jorge Luiz , Ribeiro Tatiana Avanço
Published: August 2022

Por meio de uma perspectiva coreomusical e do paradigma indiciário de Carlo Ginzburg, esse artigo analisa algumas influências do movimento modernista e da companhia dos Balés Russos de Sergei Diaghilev no balé Uirapuru (1917), composto por Heitor Villa-Lobos e protagonizado pela bailarina Eros Volúsia. Argumenta-se que os Balés Russos tenham sido uma referência de modernismo comum a ambos os artistas, influenciando Villa-Lobos a compor música para balé e proporcionando a consolidação de uma prática de dança cênica no Brasil. Embora alguns autores defendam que Villa-Lobos teria, na verdade, composto Uirapuru entre as décadas de 1920 e 1930 e, posteriormente, adulterado a data de composição para 1917, os indícios do campo da dança apontam para a concepção de Uirapuru como balé no ano de 1917. A estreia em forma de balé, no entanto, teria sido apenas em 1943, quando já existiam artistas de dança legitimamente brasileiros para performá-lo, como a bailarina Eros Volúsia.
Descriptions, notes, and a new record in Oideterus Thomson (Coleoptera, Cerambycidae, Prioninae, Anacolini)
Authors: VLASAK JOSEF , SANTOS-SILVA ANTONIO
Published: August 2022

The male of Oideterus elegans (Waterhouse, 1880) is described for the first time, female chromatic variations are reported, and the species is recorded from the Ecuadorian department of Napo. Two new species are described from Ecuador: Oideterus leoninus and O. ecuadorensis. The species-group name of O. nigrum Botero, Galileo & Santos-Silva, 2019 is corrected. Identification keys to males and females of Oideterus species are provided.
Redescription of Dentifibula viburni (Felt) (Diptera: Cecidomyiidae) and review of the genus
Authors: GAGNÉ RAYMOND J. , BERTONE MATTHEW A.
Published: August 2022

Dentifibula viburni (Felt) (Diptera: Cecidomyiidae), type species of Dentifibula Felt, is redescribed with illustrations and compared with its congeners. The genus is differentiated from the generally similar Lestodiplosis Kieffer. As far as presently known, larvae of Dentifibula prey on Diaspididae (Hemiptera: Coccoidea). The nine other species of Dentifibula are diagnosed. Dentifibula ceylanica Felt is removed from synonymy under Dentifibula obtusiloba Felt.
Two new species of the genera Leiophron Nees and Paroligoneurus Muesebeck (Hymenoptera: Braconidae) from northern India
Authors: GUPTA ANKITA , VAN ACHTERBERG CORNELIS , PATTAR ROHIT , NAVIK OMPRAKASH , MAHENDIRAN G.
Published: August 2022

Two new species of parasitoid wasps, Leiophron indefinita Gupta & van Achterberg sp. nov. (Braconidae, Euphorinae) and Paroligoneurus indicus Gupta & van Achterberg sp. nov. (Braconidae, Ichneutinae) are described and illustrated from northern India.
Long Noncoding RNA P53 Upregulated Regulator of P53 Levels Promotes Osteogenic Differentiation in Osteoporosis Progression Through Sponging miR-135a-5p
Authors: Zhang Hui , Song Jie , Zhou Xianjie
Published: August 2022

This study aimed to explore the expression of long noncoding RNA p53 upregulated regulator of P53 levels (lncRNA PURPL) and microRNA (miR)-135a-5p in osteoporosis and their role in osteogenic differentiation. The relationship between lncRNA PURPL and miR-135a-5p was confirmed by Star-Base
and luciferase reporter assay. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay was used to detect lncRNA PURPL and miR-135a-5p expression. RT-qPCR and western blot analysis were used to measure osteogenic markers expression. Alkaline phosphatase (ALP) activity
was also determined. Results indicated that lncRNA PURPL binds to miR-135a-5p. lncRNA PURPL expression was decreased and miR-135a-5p expression was increased in patients with osteoporosis. In the process of osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs), the
expression levels of osteoblast markers including RUNX family transcription factor 2 (Runx2), ALP and Osterix, and ALP activity were significantly increased. Besides, lncRNA PURPL was improved, while miR-135a-5p was down-regulated during the osteogenic differentiation of hBMSCs. Moreover,
lncRNA PURPL-siRNA significantly decreased the expression of ALP, Runx2 and Osterix, and reduced ALP activity in hBMSCs subjected to osteogenic induction, while all of these effects were reversed by miR-135a-5p inhibitor. In conclusion, lncRNA PURPL/miR-135a-5p may be a new axis for osteoporosis
treatment.
Automatic Method for Blood Vessel Diameter Measurement on Color Retinal Images
Authors: Guedri Hichem , Alotaibi Abdullah Alhumaidi
Published: August 2022

Automatic detection of retinal blood vessels and measurement of blood vessel diameter has become very useful in medical applications, including the diagnosis and monitoring of vascular therapy. This paper present a new method for the detection of retinal blood vessels from fundus images.
In addition, it accurately determines the blood vessels diameter. The proposed system consists of several stages starting from the detection of a complete blood vessel network (retinal images), a segmentation process, an extraction of blood vessel centerlines, and a new approach for the measurement
of the blood vessel diameters utilizing the circle diameter approach. The application of the proposed method is based on three publicly available databases (DRIVE, STARE, CHASE_DB and HRF), which has been conducted and compared to recently reported measurement techniques. Numerical results
demonstrate the efficacy of the proposed method achieving a success rate of 100% with 2.2454×10−4 as mean and 4.5833×10−5 as standard deviation differences. This could be harnessed in the future blood vessel measurement techniques.
MiR-219a-5p Inhibits Michigan Cancer Foundation-7 (MCF-7) Cell Migration by Regulating Zinc Finger E-Box Binding Homeobox 1 (ZEB1) Expression
Authors: Hu Fen , Chen Jiaxin , Zhang Yunfeng , Xu Ke , Sun Yuxi , Liu Yan , Cai Haifeng
Published: August 2022

The potential role of miR-219a-5p in the migration of breast cancer has not been fully elucidated. In this study, bioinformatic analysis revealed that high miR-219a-5p expression in breast cancer tissue was associated with good survival of breast cancer patients. RT-qPCR analysis indicated
that miR-219a-5p expression is significantly lower in MDA-MB-231 triple-negative breast cancer (TNBC) cells. In addition, pre-miR-219a overexpression inhibited MCF-7 cell migration and inhibited ZEB1, Twist1 and vimentin expression but promoted the expression of E-cadherin. Moreover, miR-219a-5p
mimics inhibited MCF-7 cell migration, whereas MCF-7 cell migration was promoted by the miR-219a-5p inhibitor. Furthermore, miR-219a-5p was found to inhibit the translation of ZEB1 expression by targeting the 5′-ACAAUCA-3′ motif of the ZEB1 3′UTR, and the binding motif is
conserved in multiple species. ZEB1 overexpression rescued the inhibition of cell migration induced by miR-219a-5p. Finally, an inverse correlation of miR-219a-5p and ZEB1 expression was observed in four breast cancer cell lines. Thus, miR-219a-5p inhibits MCF-7 cell migration by regulating
ZEB1 expression, and ZEB1 is the target gene of miR-219a-5p.