bluuebunny/crossref_metadata_2025 huggingface dataset:
Sosialisasi Kampanye “GEMARIKAN” (Gerakan Memasyarakatkan Makan Ikan) Melalui Produk Olahan Ikan Untuk Peningkatan Gizi Anak-anak di SDN Alue Peunyareng (ALPEN), Kecamatan Meureubo, Kabupaten Aceh Barat
Authors: Insani Sri Ayu , Khairi Ikhsanul , Hasanah Uswatun , Diansyah Akbar , Rozi Anhar , Ukhty Nabila
Published: September 2024

Protein dari ikan dibutuhkan oleh tubuh manusia karena relatif mudah dicerna. Kebijakan untuk mendukung ketersediaan sumberdaya laut sebagai sumber protein hewani memainkan peranan yang penting dalam meningkatkan pola makan sehingga dapat mencegah terganggunya pertumbuhan anak. Anak-anak merupakan cikal bakal generasi penerus bangsa. Pembentukan kualitas anak sejak masa sekolah akan mempengaruhi kualitas Sumber Daya Manusia (SDM) saat mereka mencapai usia produktif. Anak usia sekolah adalah golongan yang memerlukan perhatian dalam konsumsi makanan dan zat gizi. Tumbuh dan berkembangnya anak usia sekolah yang optimal tergantung pemberian nutrisi dengan kualitas dan kuantitas yang baik serta benar. Tingkat konsumsi ikan pada keluarga nelayan dipengaruhi oleh beberapa hal yakni dari pendapatan, jumlah anggota keluarga, persepsi harga ikan, selera dan juga tingkat pendidikan atau mungkin juga tingkat pengetahuan mengenai manfaat mengkonsumsi ikan. Ragam jenis hasil olahan ikan yang menarik diharapkan dapat meningkatkan pola konsumsi ikan pada masyarakat, khususnya pada anak-anak yang dalam masa pertumbuhan. atas dasar tersebut maka perlu diadakannya kampanye GEMARIKAN (Gerakan Memasyarakatkan Makan Ikan) di sekolah khususnya Sekolah Dasar. Kegiatan ini bertujuan untuk memberikan edukasi mengenai manfaat mengonsumsi ikan, dan mengalihkan jajanan pada hasil olahan ikan yang menyehatkan dan bermanfaat bagi pertumbuhan dan perkembangan anak.
Effect of Natural Feeding Daphnia sp. enriched with Spirulina Flour on the Survival and Growth of Betta Fish (Betta sp.) Seeds
Authors: Maulana Teuku Alrian , Komariyah Siti , Febri Suri Purnama , Harahap Antoni
Published: September 2024

The aim of this research is to analyze the influence of Daphnia sp. enriched with Spirulina flour on the survival and growth of Betta fish seeds (Betta sp.) and determine the best dosage of Daphnia sp. that is enriched with Spirulina flour on the survival and growth of Betta fish seeds (Betta sp.). The method used in this research is an experimental method using a Completely Randomized Design (CRD) with 4 treatments and 3 replications for each treatment, namely, P1 Daphnia sp. enriched with spirulina flour 1 g/L, P2 Daphnia sp. enriched with spirulina flour 2 g/L, P3 Daphnia sp. enriched with spirulina flour 3 g/L, and P4 Daphnia sp. enriched with spirulina flour 4 g/L. Daphnia sp. enriched with Spirulina at different doses in Betta fish seeds (Betta sp.) had a significant effect (P<0.05) on survival and growth performance. The greater the dose of Spirulina flour enriched in Daphnia sp. the higher the survival and growth performance of Betta fish seeds (Betta sp.), and the best treatment is P4 with a dose of 4 g of Spirulina.
PENGARUH SISTEM ZONASI TERHADAP PRESTASI BELAJAR PESERTA DIDIK KELAS VII DI SMP NEGERI 9 PALU
Authors: Sabri Triani Wahyuni , Listiqowati Ika , Putra Exsa
Published: September 2024

Penelitian ini bertujuan untuk menganalisis pengaruh sistem zonasi terhadap prestasi belajar siswa kelas VII di SMPN 9 Palu. Metode yang digunakan dalam penelitian ini adalah deskriptif dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah peserta didik kelas VII SMP Negeri 9 Palu yang berjumlah 231 siswa kemudian diambil 25%. Populasi peserta didik yang dijadikan sampel sebanyak 57. Pengumpulan data dalam penelitian ini menggunakan teknik observasi, wawancara, angket dan dokumentasi. Instrumen penelitian diuji menggunkaan uji validitas dan uji reliabilitas Analisis data menggunakan  statistik deskriptif persentase, statistik korelasi, statistik chi kuadrat, statistik uji linearitas dan uji homogenitas. Terbukti hasil perhitungan prestasi belajar siswa pada tabel konversi ditemukan nilai rata-rata prestasi belajar siswa sebesar 56,86 yang berada dalam kategori sedang. Hasil perhitungan analisis pada uji normalitas menggunakan statistik chi kuadrat diperoleh chi kuadrat hitung = 13.97 dengan chi kuadrat tabel = 11.070, maka chi kuadrat hitung < chi kuadrat tabel. Hasil analisis pada uji linearitas menggunakan statistik Fobs di peroleh  = 0,596  dengan Ftabel = 5,05 maka Fobs ≤ Ftabel. Hasil analisis pada uji homogenitas X2obs = 0,347 dengan X2 tabel =3,841 maka X2obs ≤ X2tabel.  Uji-t diperoleh t-hitung = 12.681 dengan t-tabel = 0.632. Karena nilai t-hitung > t-tabel maka dapat disimpulkan bahwa korelasi tersebut signifikan atau hipotesis kerja (Ha) diterima.
KERAWANAN LONGSOR DI KECAMATAN PURABAYA, KABUPATEN SUKABUMI
Authors: Prawira Khairul Yuda
Published: September 2024

Kejadian tanah longsor di Indonesia terus meningkat dari tahun ke tahun, terutama di wilayah pegunungan selama musim hujan. Faktor tektonik, batuan vulkanik mudah rapuh, dan iklim tropis basah memperbesar potensi bencana longsor. Perubahan tataguna lahan yang disebabkan oleh faktor antropogenik dan alam semakin memperparah risiko longsor, menyebabkan kerugian jiwa dan harta benda. Penelitian ini fokus pada Kecamatan Purabaya, Kabupaten Sukabumi, dengan tujuan menganalisis kerawanan longsor. Hasil analisis menciptakan Peta Kerawanan Tanah Longsor di Kecamatan Purabaya, menggunakan metode skoring dengan overlay peta curah hujan, jenis batuan, kemiringan lereng, penggunaan lahan, dan jenis tanah. Ditemukan 156 unit lahan dengan klasifikasi kerawanan rendah, sedang, tinggi, dan sangat tinggi. Wilayah dengan tingkat kerawanan tinggi dan sangat tinggi mencakup 49,52% dari luas total, sementara yang rendah hanya 6,19%. Kecamatan Purabaya dominan dengan tingkat kerawanan tinggi, menyumbang 49,52% dari luas total, sementara luas yang rendah hanya 6,19%. Temuan ini memberikan landasan untuk pengelolaan risiko bencana longsor di wilayah tersebut.
SDGs HUBUNGAN ANTARA PERAN KONSERVASI TERHADAP SUSTAINABLE DEVELOPMENT GOALS (SDGs)
Authors: Triardianti Annisa
Published: September 2024

Pembangunan merupakan proses perubahan yang berkelanjutan untuk menuju pada kondisi yang lebih baik yang berdasarkan tujuan-tujuan tertentu. Konferensi Lingkungan di Stockholm pada tahun 1972 dikatakan sebagai tonggak awal diperkenalkannya pembangunan berkelanjutan (Sustainable Development). Dapat disimpulkan keterkaitan Rencana Pembangunan Jangka Menengah Nasional (RPJMN) dengan Sustainable Development Goals (SDGs) terdapat pada visi dan misi utama yang sama untuk mensejahterakan kehidupan manusia terkhusus Indonesia yang untuk mensejahterakan seluruh rakyatnya melalui keikutsertaan Indonesia dalam mewujudkan SDGs yang dianggap penting untuk menunjang pembangunan di Indonesia. Metode penelitian yang digunakan yaitu metode studi kepustakaan atau literatur review. Literatur review sendiri merupakan ikhtisar komprehensif tentang penelitian yang sudah dilakukan mengenai topik yang sama untuk menunjukkan kepada pembaca apa yang sudah diketahui tentang topik tersebut dan apa yang belum diketahui guna mencari rasional dari penelitian yang sudah dilakukan.
Desenvolvendo inclusão e cooperação através do Goalball nas aulas de Educação Física
Authors: Macedo Souza Bruno
Published: September 2024

Este artigo foi elaborado com base em um Projeto de Intervenção, realizado como requisito da disciplina de Trabalho de Conclusão de Curso, inserido em um programa de pós-graduação em esporte escolar. Seu objetivo foi desenvolver valores de inclusão e cooperação por meio do Goalball nas aulas de Educação Física. A execução do projeto foi direcionada a estudantes, nos níveis do 6° ao 9° ano, de uma instituição de ensino pública, visando aprimorar suas atitudes colaborativas no ambiente escolar. Quanto aos resultados obtidos com os alunos, é relevante notar que eles experimentaram de forma marcante as atividades do projeto, se mantiveram engajados no Goalball e também demonstraram empatia para com seus colegas. Essas ações, que visavam melhorar os valores entre os estudantes, deveriam ser implementadas de forma consistente na rotina educacional, já que a conscientização sobre a diversidade e o estímulo à colaboração entre colegas são de extrema importância.
Rezultati LiDAR-skog snimanja i terenskih pregleda prostora Prigorja
Authors: Vuković Miroslav , Mavrović Mokos Janja , Ovčarić Franka
Published: September 2024

Projekt TRANS RIVERS, financiran od strane Hrvatske zaklade za znanost, bavi se proučavanjem prapovijesnih lokaliteta i komunikacijskih putova uz rijeke Savu, Sutlu i Krapinu na području Prigorja. Spomenuti prostor predstavlja izazovan krajolik za arheološka istraživanja zbog prirodnih čimbenika (poplava i erozija), ali i onih uzrokovanih čovjekom (kamenolomi i urbanizacija). Jedan od glavnih ciljeva projekta je ubiciranje novih lokaliteta na području Marijagoričkog pribrežja te obronaka Medvednice koji nisu bili pod utjecajem ranije navedenih destruktivnih procesa. LiDAR-sko snimanje najbolje je odgovaralo ovim istraživačkim problemima. U okviru ovog istraživanja upotrijebljeni su podaci s tri različita projekta laserskog skeniranja iz zraka kako bi se osigurala odgovarajuća pokrivenost područja istraživanja. U ovom radu predstavljeni su preliminarni rezultati prvih provedenih terenskih istraživanja i interpretacije LiDAR-skih podataka s posebnim osvrtom na prapovijesne lokalitete koji su u fokusu projekta.
Análisis de dispersión de la contaminación en cuerpos de agua por lixiviados, provenientes del botadero de basura Curgua, Guaranda - Ecuador
Authors: Torres Murillo Katherin Jhomayra , Gaibor Chávez Juan
Published: September 2024

Introducción: la disposición final de residuos sólidos municipales constituye una problemática ambiental y sanitaria actual. Objetivo: el objetivo de la investigación fue analizar la dispersión de la contaminación en cuerpos de agua, por los lixiviados provenientes del botadero de basura denominado Curgua, Cantón Guaranda – Ecuador. Metodología: las muestras de agua se recolectaron en diferentes puntos: al ingreso al cuerpo de agua dulce localizado a 60 m de la fuente que constituye el punto 2; luego a 500 m, 1.5 km, 2 km y 3 km. El análisis se realizó por triplicado durante 3 semanas. Se realizaron análisis físico - químicos de acuerdo con la metodología de la empresa HACH. Se determinó la dinámica de la concentración de los principales compuestos de acuerdo con los puntos de muestreo. Resultados: se presenta los valores de los principales estadísticos de los parámetros de calidad analizados, el promedio, desviación estándar, coeficiente de variación. Se encontró que a medida que aumenta la distancia del punto de origen los valores de los parámetros disminuyen parcialmente, pero aún persisten, lo que provoca la constante presencia de contaminación en el cuerpo de agua dulce. Conclusiones: existe una correlación entre algunos parámetros, esto se debería por el tipo y composición físico química y biológica de los residuos que se generan. Este hecho incrementa el riesgo de mantener e incluso aumentar la contaminación en épocas en las que se puede influir directamente en la generación de residuos sólidos. Área de estudio general: Ciencias del Ambiente. Área de estudio específica: Manejo y disposición de residuos. Tipo de estudio:  Artículo original
THE CLINICAL EFFECTIVENESS OF ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER: A SYSTEMATIC REVIEW
Authors: Çetintürk İskender , Yiğit Vahit
Published: September 2024

Lung cancer presents a significant epidemiological and economic burden worldwide. This deadly type of cancer ranks second in incidence and first in mortality among all cancers. The rapid increase in new and expensive treatment options places a substantial financial strain on public healthcare systems. Given the limited healthcare resources, the economic evaluation of new cancer drugs is crucial for ensuring the sustainability of healthcare systems and improving patients' access to treatments. This study aims to systematically review health state utility values (HSUVs) associated with traditional chemotherapy and targeted therapies in the first-line treatment of advanced or metastatic non-small cell lung cancer (NSCLC). A search was conducted in PubMed, EMBASE, and BioMed databases to identify publications reporting HSUVs, and 10 studies were selected from 1319 based on predefined criteria. The study found that HSUVs for targeted therapies were consistently higher across all health states compared to traditional chemotherapy. The included publications provide a comprehensive framework of HSUVs applicable to this disease and highlight the need for more empirical research to obtain a broader range of HSUVs for NSCLC.
Hubungan Paparan Informasi dengan Tingkat Kecemasan Pada Ibu Hamil
Authors: Agustini Ni Komang Tri , Sagitarini Putu Noviana , Wahyuningsih Luh Gde Nita Sri
Published: September 2024

Anxiety is a common experience during pregnancy and can have significant implications for both the mother's health and the developing fetus. One factor that can contribute to maternal anxiety is exposure to information. The vast amount of information available to pregnant women through various sources, such as books, websites, and social media, can be overwhelming and confusing. Furthermore, the quality and accuracy of information available online can vary widely. This can make it difficult for pregnant women to determine which sources are reliable and trustworthy. As a result, they may become overwhelmed with doubt and uncertainty, leading to increased anxiety. The purpose of the study was to determine the relationship between exposure to information and the level of anxiety of pregnant women. The study used a descriptive cross-sectional correlation design using the Pregnancy Anxiety Questionnaire-Revised for All Pregnant Women Regardless of Parity (PRAQ-R2). The sample used 80 respondents using consecutive sampling technique. Data analysis using Chi Square test. The results showed that information exposure including exposure to information (p=0.01), confidence in information (p=0.009), and information support (0.021) were associated with the level of anxiety of pregnant women. This study highlights the importance of providing clear, accurate, and supportive information to pregnant women to help reduce anxiety and promote positive mental health outcomes.
Faktor Penggunaan Metode Kontrasepsi Jangka Panjang (MKJP)
Authors: Simanjuntak Vivin Aktika , Hasibuan Rapotan
Published: September 2024

The escalating population of Indonesia is a pressing demographic challenge, contributing to a surge in the birth rate. Long-Term Contraceptive Methods (LTCM) offer a viable strategy for postponing and spacing pregnancies, thereby mitigating the adverse effects of population growth. However, LTCM utilization among women in the Glugur Health Center, Medan, remains notably low at 26.9%, indicating a significant gap in contraceptive access and adoption. To elucidate the factors influencing LTCM utilization, this study employed a cross-sectional research design. Data collection involved in-depth interviews with women residing within the Glugur Health Center's catchment area. The gathered data were subjected to rigorous analysis using univariate and bivariate statistical techniques. The findings revealed a strong correlation between Age (p=0,013; OR= 0,353), education (p=0.002; OR=3.594), the number of children (p=0.021; OR=2.545), knowledge (p=0.000; OR=4.278), attitudes (p=0.000; OR=10,818), source of information (p=0.017; OR=2,600), spouse's support (p=0.009; OR=3,135) and support of the health workers (p=0.028; OR=2.527) with LTCM utilization. The study's results underscore the critical role of comprehensive education and support in promoting LTCM adoption. Health officials and the Glugur Health Center should prioritize implementing targeted interventions to enhance women's knowledge and address any misconceptions regarding LTCM. Furthermore, fostering supportive environments, both within families and healthcare settings, is essential for encouraging consistent LTCM use. By addressing these key determinants, policymakers can significantly increase LTCM uptake and contribute to sustainable population growth in Indonesia.
Hypnobreastfeeding Meningkatkan Pengeluaran Asi Pada Ibu Nifas
Authors: Gaparini Alifiani , Astutik Linda Puji , Meyasa Lola
Published: September 2024

Hypnobreastfeeding, a relaxation technique that incorporates positive affirmations, has emerged as a promising strategy for enhancing milk production in postpartum women. By inducing a state of deep relaxation and focusing the mind on positive thoughts, hypnobreastfeeding can stimulate the release of prolactin and oxytocin, hormones crucial for milk synthesis and letdown. This study aimed to investigate the impact of hypnobreastfeeding on breastfeeding expenditure in postpartum women at UPTD Pahandut Health Center. A pre-experimental design with a one-group pretest-posttest approach was used. This design involved measuring participants' outcomes before and after the intervention, allowing for an assessment of any changes that occurred. The total sample size consisted of 36 individuals. The results of the study demonstrated a significant increase in milk production among the participants (p-value = 0.000). This suggests that hypnobreastfeeding can be an effective tool for augmenting milk supply, particularly for women facing challenges in breastfeeding. Hypnobreastfeeding offers a promising approach for increasing milk production in postpartum women. The findings of this study suggest that it can be a valuable tool for supporting breastfeeding and promoting the health and well-being of both mother and infant.
Assessment of Pathologies Caused by Anamorphous Fungi Distributed in Some Areas of Azerbaijan According to the Degree of Hazard
Authors: Jabrailzade S. , Aslanova S.
Published: September 2024

As a result of the conducted studies, the spread of 127 types of mushrooms from different areas of Azerbaijan was revealed, of which 94 belonged to the anamorphs of bag mushrooms. During the assessment of recorded anamorphic fungi according to the pathologies they cause, it was clear that 60 of them belong to phytopathogens and 25 to opportunists. The remaining 19 species are characterized as having uncertain status in terms of the distribution noted today.
Morphological Changes in Allergenic Pollen as a Bioindicator
Authors: Kobzar V.
Published: September 2024

Since the anther opens and the pollen grains travel in the atmosphere, they can come into contact with solid and gaseous particles, and the exine can become contaminated with various adherent particles. Pollen and solid particles are among the most common triggers of bronchial asthma. Increased allergenicity of pollen grains will be determined by chemical reactions between pollutants and pollen, as well as non-specific modulation of the mechanisms of synthesis of many proteins, lipids and enzymes in response to environmental stress due to urbanization and climate change. This situation seriously complicates the identification of pollen to a taxon during traditional monitoring and further complicates the calculation and interpretation of the results obtained during research and automatic determination. To classify tetramorphic pollen from aerobiological samples and explain the mechanism of the identified changes. Determination of mutagenic contamination and a method for integral assessment of pollen viability and damage under a light microscope. Pollen from aerobiological samples was examined under a scanning electron microscope (Hitachi): a high-power imaging technique that uses electron beams to create detailed images of the ultrastructure of pollen grains. Unidentified, tetramorphic pollen from aerobiological samples from sites with varying degrees of contamination can be conditionally classified into 4 types: 1) shapeless lumps of sporopollenin with various outgrowths, cracks and cavities that arose during pollen ontogenesis; 2) atypical ornamentation of sculpture, such as large tubercles - swellings with a smooth surface; 3) atypical form, but with partially preserved sculpture, where in places species-specific features can be identified and pollen can be identified to a taxon; 4) conglomerates. The study of the vitality (viability) and damage of the cocksfoot pollen under a light microscope from observation points with different anthropogenic loads showed the dependence of these indicators on the level of pollutants: with their increase, viability decreases, although it remains quite high. The data obtained are important for assessing allergenic pollen as a bioindicator of environmental changes. An integrated assessment of the enzymatic activity of pollen and the degree of its damage can be used for the purposes of bioecological monitoring.
Amaranthaceae Pollen Trends in the Air
Authors: Kobzar V. , Osmonbaeva K.
Published: September 2024

Understanding the trends of airborne pollen allergens is of great importance given the high prevalence and socioeconomic impact of pollen-related allergic diseases globally. To study the morphological features of Amaranthaceae pollen, assess its contribution to the aerobiological situation in the city of Karakol and identify periods of increased concentration in order to improve the diagnosis and prevention of pollinosis symptoms in patients. Aerobiological sampling using a Lanzoni pollen trap was carried out from April to October over a three-year period (2015–2017) in Karakol city. Pollen identification and differential counting were performed according to current standard methodology and specially developed guides and atlases. Pollen characteristics of 4 Amaranthaceae species were visualized using scanning electron microscopy (Hitachi) to provide a detailed understanding of the surface structure and ornamentation of pollen grains. The decadal curve of Amaranthaceae pollen concentration in Karakol is unimodal, with often overlapping quantitative characteristics: 6615 (2nd decade of August 2015), 1326 (1st decade of 2016), 444 pollen grains / m3 (1st decade of 2017). At the same time, strong interannual variability of atmospheric pollen levels was observed, depending both on the pollen production of the plants themselves and on meteorological parameters, especially temperature and precipitation, changes in the traditional farming system. The response of summer-flowering Amaranthaceae weeds to climate change was demonstrated, which consists in a decrease in the annual pollen index, which corresponds to the global trend. Peak concentrations of Amaranthaceae pollen many times exceeded clinical threshold values in the air. On the surface of the Bassia scopariapollen exine, the ultrastructure study revealed the smallest (1.5-2.0 μm) granules of sporopollenin or orbicules (Ubisch bodies), which play a role in the spread of allergens. The obtained data are important in terms of increasing public awareness of the dominant pollen of the Amaranthaceae family, optimizing diagnostics, treatment and prevention of pollinosis.
The Role of Water in the Life of Living Organisms
Authors: Mammadov H. , Gulamova A.
Published: September 2024

The article discusses the biological, physical, and chemical properties of natural drinking and bottled mineral waters and examines their mechanism of effect on human health. It provides information on the criteria that drinking water must meet to be considered safe and offers a comparative analysis of mineral waters. The use of various types of mineral waters in the treatment of specific diseases is investigated. The physical and chemical indicators of mineral waters produced in the Nakhchivan Autonomous Republic and their benefits are described. The research concludes that while proper and effective use of mineral waters is beneficial to human health, improper use without considering their composition can lead to serious safety issues.
Analysis of Yield Indicators of Eastern Persimmon (Diospyros kaki L. f.) Varieties Grown in the Territory of the Sheki-Zagatala Region of the Republic of Azerbaijan
Authors: Abdullaeva N.
Published: September 2024

The article analyzes phenological observations and yield indicators of eastern persimmon varieties cultivated in the Sheki-Zagatala region of the Azerbaijan Republic. The existing 10 varieties of eastern persimmon (Diospyros kaki L. f.) were studied: Hiakume, Guyboshi, Tanenashi, Tamopan, Sidles, Amon-kaki, Geili, Tranta-kaki, Khachia and Kaki-mela. The beginning of the growing season for persimmon depends on the weather conditions of the year, the swelling of shoots is in early April (04/10) at an average air temperature of 8.3–9.3°C, and the opening of shoots is at the end of April (04/21) at an average daily temperature of 12.6–13°C. Flowering by variety began earliest on May 15 for the Hiakume variety and ended on May 30 for the Sidles variety; the flowering period lasted approximately 15 days. The earliest start of fruit ripening was observed in the Hiakume variety on October 12, and the latest in the Khachia variety - on October 20. The fruit ripening period lasted from October 12 to October 30. The earliest leaf fall began at the beginning of May for the variety Tamopan (05.11) and ended at the end of November for the variety Amon-khaki (28.11). The duration of the growing season ranged from 216-227 days. The highest yield was 268.5 kg per tree for the Tamopan variety, and the lowest was 71.0 kg for the Khachia variety. The weight of 1 persimmon fruit for the Tamopan variety was 350 g, for the Geili variety — 110 g. The number of fruits on the tree for the Geili variety was 2730 pcs., for the Sidles variety — 140 pcs. In the Sheki-Zagatala region, the main part of the areas for growing and producing eastern persimmons is in the Belokan and Zagatala regions, and over the years there has been an increase in these areas.
Comparative Analysis of the Distribution of the Main Helminthiasis Causative Agents in the Absheron Peninsula and Khizi Region
Authors: Aghayeva A. , Shammadova I.
Published: September 2024

The research was conducted on sheep farms located in the Absheron region in 2015-2020. The major helminth fauna in sheep in the private and farmer farms of the Absheron region was found to consist of helminth species: Fasciola hepatica, F. gigantica, Dicrocoelium lanceatum, Paramphistomum cervi, Moniezia expansa, M. benedeni, Taenia hydatigena, T. ovis, Multiceps multiceps, Echinococcus granulosus, Protostrongylus hobmaieri, P. kochi, P. railleti, Muellerius capillaris, Trichocephalus ovis, Chabertia ovina, Haemonchus contortus, Dictyocaulus filaria. The extensiveness and intensity of the distribution of the 18 main helminths detected in the region by the complete helminthological dissection method in 19 research areas (14 in the Absheron peninsula: Zire, Hovsan, Mashtagha, Mehdiabad, Gobu, Sulutepe, Z. Taghiyev, Fatmayi, Novkhani, Mammadli, Khirdalan, Jeyranbatan, Mushvigabad, Guzdek; 5 in the Khizi region: Yeni Yashma, Shorabad, Altiaghaj, Gizilgazma, Tudar) are described in tables. Higher invasion levels were identifi­ed for T. ovis(43.2%, 1-53 samples), E. granulosus (39.2%, 1-18 samples), H. contortus (35.0%, 2-56 samp­les), and they we­re con­si­de­red the do­mi­nant hel­minth spe­ci­es of the re­gi­on. Ba­sed on the complete helminthological dissection, in the Absheron peninsula, IE was 17.7% and II was 1-64 samples, and in the Khizi district, IE was 29.0% and II was 1-83 samples. Thus, complete helminthological examination methods allowed us to conclude that the infection rate in the Khizi region is higher than in the Absheron Peninsula. This makes it necessary for farmers and veterinarians to start veterinary sanitary measures, both prophylactic and treatment measures against helminths in the Khizi district.
Effect of Adaptations on Morphophysiological Indicators of High-Producing Dairy Cows
Authors: Taghiyev J.
Published: September 2024

In this article, we conduct a study of the impact of adaptation of dairy cows. The aim is to study the influence of the morphological basis of adaptation. Health is one of the main indicators of the degree of adaptation of animals. The state of the body, in which all its organs, systems and functions interact with each other in an optimal mode and are harmoniously balanced with environmental factors, indicates a high degree of adaptability of animals. Currently, highly effective methods have been developed in physiology to determine the level of life support of the body and the compliance of the external environment with the needs of animals. The ability of biological systems to withstand changes and maintain dynamic constancy of composition, function and properties is the essence of homeostasis, the body and the population as a whole.
Computation of Analog Theorems for the Dirichlet Eta Function
Authors: Annamalai Chinnaraji
Published: September 2024

The Riemann zeta function is the most important special function in the significantly large family of zeta-functions. The Riemann zeta function plays a vital role in the analytic number theory and has applications in applied statistics, physics, and probability theory. This paper presents several analog theorems for the Riemann zeta function.
Effective Cultivation of Green Cotton
Authors: Zheng Shufeng
Published: September 2024

This book is one of the series of Rural Revitalization: Modern Planting Practical Technology. This book is aimed at the various problems on the conventional cotton planting process which is not only complex and difficult to achieve large-scale mechanized production, but also with long production cycle, low level of mechanization, more labors, and high inputs of fertilizer and pesticide. On the basis of summarizing the recent research on simple and efficient technology and production experience, this book systematically introduces the reduction of chemical fertilizers and pesticides, light and efficient cultivation, pests and weeds green prevention, cultivating management, and other new techniques.
Prenatal glucocorticoids exposure and adverse cardiovascular effects in offspring
Authors: Zhao Chenxuan , He Lei , Li Lingjun , Deng Fengying , Zhang Meihua , Wang Changhong , Qiu Junlan , Gao Qinqin
Published: September 2024

Glucocorticoids (GCs) are steroid hormones fundamental to the body’s normal physiological functions and are pivotal in fetal growth and development. During gestation, the mother’s cortisol concentration (active GCs) escalates to accommodate the requirements of fetal organ development and maturation. A natural placental GCs barrier, primarily facilitated by 11β hydroxysteroid dehydrogenase 2, exists between the mother and fetus. This enzyme transforms biologically active cortisol into biologically inactive corticosterone, thereby mitigating fetal GCs exposure. However, during pregnancy, the mother may be vulnerable to adverse factor exposures such as stress, hypoxia, caffeine, and synthetic GCs use. In these instances, maternal serum GCs levels may surge beyond the protective capacity of the placental GCs barrier. Moreover, these adverse factors could directly compromise the placental GCs barrier, resulting in excessive fetal exposure to GCs. It is well-documented that prenatal GCs exposure can detrimentally impact the offspring’s cardiovascular system, particularly in relation to blood pressure, vascular function, and heart function. In this review, we succinctly delineate the alterations in GCs levels during pregnancy and the potential mechanisms driving these changes, and also analyze the possible causes of prenatal GCs exposure. Furthermore, we summarize the current advancements in understanding the adverse effects and mechanisms of prenatal GCs exposure on the offspring’s cardiovascular system.
The long-term prognostic implications of free triiodothyronine to free thyroxine ratio in patients with obstructive sleep apnea and acute coronary syndrome
Authors: Zhou Yun , He Qian , Ai Hui , Zhao Xuedong , Chen Xiuhuan , Li Siyi , Zhang Zekun , Fan Jingyao , Gong Wei , Nie Shaoping
Published: September 2024

Objective

Obstructive sleep apnea (OSA) and thyroid dysfunction frequently overlap clinically and are risk factors for cardiovascular disease. The free triiodothyronine to free thyroxine (FT3/FT4) ratio as a novel biomarker of cardiovascular disease prognosis, but the impact of the FT3/FT4 ratio on the prognosis of OSA in patients with acute coronary syndromes (ACS) remains uncertain.

Methods

In this prospective cohort study, 2160 patients with ACS were recruited and underwent portable sleep monitoring at Beijing Anzhen Hospital from June 2015 to January 2020. OSA was diagnosed when apnea-hypopnea index of ≥15 events/h. Patients were further divided into tertiles according to FT3/FT4 ratio. All patients had scheduled follow-up visits at 1, 3, 6, 9 and 12 months after discharge, with subsequent outpatient visits or telephone follow-up visits every 6 months. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), including cardiovascular death, myocardial infarction (MI), stroke, ischemia-driven revascularization, or hospitalization for unstable angina or heart failure.

Results

Among 1,547 euthyroid patients enrolled (mean age, 56.0 ± 10.5 years), 812 patients (52.5%) had OSA. The FT3/FT4 ratio between OSA and non-OSA patients was not significantly different. During 2.8 (1.4, 3.5) years follow up, the risk of MACCE increased with the decreasing FT3/FT4 tertiles in patients with OSA (tertile3 as reference, tertile2: hazard ratio (HR) 1.26, 95% CI: 0.85-1.86, P = 0.255; tertile1: 1.60, 95% CI 1.11-2.32; P = 0.013). After adjustment for confounders, the lowest FT3/FT4 tertile was still independently associated with an increased risk of MACCE (adjusted HR 1.66, 95% CI 1.11-2.50, P = 0.015).

Conclusion

Lower FT3/FT4 ratio associated with poor prognosis in patients with ACS and OSA.
Artificial intelligence empowerment in China’s energy landscape: enhancing power grid investment efficiency
Authors: Zhou Ming , Ma Li , Zhang Tongyan , Wu Qiang , Zhou Yingbo , Sun Liping
Published: September 2024

Against the backdrop of China’s initiative to construct a new power system focusing on new energy, optimizing power grid investment holds significant importance. This study aims to investigate whether the application of artificial intelligence (AI) contributes to power grid investment efficiency. By considering diverse factors, power grid investment efficiency in China is assessed by using a Slack-based measure model. Then we analyze the relationship between AI and power grid investment efficiency, as well as their nonlinear threshold effect. We find a notable increase in China’s power grid investment efficiency, accompanied by evident regional differences. In addition, the utilization of AI exerts a significantly positive effect on power grid investment efficiency. Particularly, such a promoting effect is more pronounced in the China Southern Power Grid cohort and remains significant during the 12th Five-Year Plan period. Moreover, grid investment exhibits a double-threshold effect, and it diminishes the contributing effect of AI on power grid investment efficiency. AI shows a single threshold effect on power grid investment efficiency as electricity sales increase, and the positive impact manifests only when electricity sales surpass a specific threshold. These insights are important for the strategic deployment of power grid projects through using AI.
Maple compounds prevent biofilm formation in Listeria monocytogenes via sortase inhibition
Authors: Elbakush Ahmed M. , Trunschke Oliver , Shafeeq Sulman , Römling Ute , Gomelsky Mark
Published: September 2024

The Pss exopolysaccharide (EPS) enhances the ability of the foodborne pathogen Listeria monocytogenes to colonize and persist on surfaces of fresh fruits and vegetables. Eradicating listeria within EPS-rich biofilms is challenging due to their increased tolerance to disinfectants, desiccation, and other stressors. Recently, we discovered that extracts of maple wood, including maple sap, are a potent source of antibiofilm agents. Maple lignans, such as nortrachelogenin-8’-O-β-D-glucopyranoside and lariciresinol, were found to inhibit the formation of, and promote the dispersion of pre-formed L. monocytogenes EPS biofilms. However, the mechanism remained unknown. Here, we report that these lignans do not affect Pss EPS synthesis or degradation. Instead, they promote EPS detachment, likely by interfering with an unidentified lectin that keeps EPS attached to the cell surfaces. Furthermore, the maple lignans inhibit the activity of L. monocytogenes sortase A (SrtA) in vitro. SrtA is a transpeptidase that covalently anchors surface proteins, including the Pss-specific lectin, to the cell wall peptidoglycan. Consistent with this, deletion of the srtA gene results in Pss EPS detachment from listerial cells. We also identified several additional maple compounds, including epicatechin gallate, isoscopoletin, scopoletin, and abscisic acid, which inhibit L. monocytogenes SrtA activity in vitro and prevent biofilm formation. Molecular modelling indicates that, despite their structural diversity, these compounds preferentially bind to the SrtA active site. Since maple products are abundant and safe for consumption, our finding that they prevent biofilm formation in L. monocytogenes offers a viable source for protecting fresh produce from this foodborne pathogen.
Gut microbiota and autoimmune thyroid disease: a bidirectional Mendelian randomization study and mediation analysis
Authors: Fang Yiqiao , Zhang Xinyue , Huang Rui , Liu Jiaye , Li Zhihui
Published: September 2024

Background

The gut microbiota (GM) plays a pivotal role in influencing various health outcomes, including immune-mediated conditions, but its potential association with autoimmune thyroid disease (AITD) remains underexplored. We aimed to investigate the potentially pathogenic or protective causal impacts of specific GM on two types of AITD, namely Graves’ disease and Hashimoto’s thyroiditis, and analyzed the mediating effect of 731 immune cell phenotypes.

Methods

Leveraging pooled genome-wide association study (GWAS) data of 211 gut microbiota traits, 731 immune cell phenotypes, and two types of AITD (Hashimoto’s thyroiditis and Graves’ disease), we performed bidirectional Mendelian randomization (MR) analyses to explore the causal relationships between the GM and AITD. Subsequently, we employed a multivariable MR analysis to discover potential mediating immune cell traits. Additionally, sensitivity analyses were utilized to ensure the reliability of the outcomes.

Results

Our analysis revealed that a total of 7 GM taxa were positively associated with AITD, and other 14 taxa showed a negative correlation with AITD. Furthermore, we identified several immune cell traits that mediated the effects of GM on AITD. Most notably, Actinobacteria (p) presented protective effects on Hashimoto’s thyroiditis via CCR2 on myeloid Dendritic Cell (5.0%), and Bifidobacterium (g) showed facilitating effects on Graves’ disease through CD39+ CD4+ T cell %CD4+ T cell (5.0%) and CD14 on CD33+ HLA DR+ CD14dim (12.2%).

Conclusion

The current MR study provides evidence supporting the causal relationships between several specific GM taxa and AITD, and further identified potential mediating immunophenotypes.
The ROSMAP project: aging and neurodegenerative diseases through omic sciences
Authors: Pérez-González Alejandra P. , García-Kroepfly Aidee Lashmi , Pérez-Fuentes Keila Adonai , García-Reyes Roberto Isaac , Solis-Roldan Fryda Fernanda , Alba-González Jennifer Alejandra , Hernández-Lemus Enrique , de Anda-Jáuregui Guillermo
Published: September 2024

The Religious Order Study and Memory and Aging Project (ROSMAP) is an initiative that integrates two longitudinal cohort studies, which have been collecting clinicopathological and molecular data since the early 1990s. This extensive dataset includes a wide array of omic data, revealing the complex interactions between molecular levels in neurodegenerative diseases (ND) and aging. Neurodegenerative diseases (ND) are frequently associated with morbidity and cognitive decline in older adults. Omics research, in conjunction with clinical variables, is crucial for advancing our understanding of the diagnosis and treatment of neurodegenerative diseases. This summary reviews the extensive omics research—encompassing genomics, transcriptomics, proteomics, metabolomics, epigenomics, and multiomics—conducted through the ROSMAP study. It highlights the significant advancements in understanding the mechanisms underlying neurodegenerative diseases, with a particular focus on Alzheimer's disease.
Study of a precise treatment protocol for patients with consciousness disorders based on the brain network analysis of functional magnetic resonance imaging
Authors: Wang Pingzhi , Xiang Jie , Niu Yan , Wei Jing , Lan Caiqin , Li Xiangping , Xu Liying , Yin Yajie , Wang Hongxiong , Zhang Tao , Yang Lei , Xing Hao , Fan Shasha , Niu Qing , Kang Huicong , Liang Ying
Published: September 2024

Objective

How to conduct objective and accurate individualized assessments of patients with disorders of consciousness (DOC) and carry out precision rehabilitation treatment technology is a major rehabilitation problem that needs to be solved urgently.

Methods

In this study, a multi-layer brain network was constructed based on functional magnetic resonance imaging (fMRI) to analyze the structural and functional brain networks of patients with DOC at different levels and to find regulatory targets (imaging markers) with recovery potential for DOC. Then repeated transcranial magnetic stimulation (rTMS) was performed in DOC patients to clinically validate.

Results

The brain network connectivity of DOC patients with different consciousness states is different, and the most obvious brain regions appeared in the olfactory cortex and precuneus. rTMS stimulation could effectively improve the consciousness level of DOC patients and stimulate the occipital lobe (specific regions found in this study) and the dorsolateral prefrontal cortex (DLPFC), and both parts had a good consciousness recovery effect.

Conclusion

In clinical work, personalized stimulation regimen treatment combined with the brain network characteristics of DOC patients can improve the treatment effect.
Exploring the impact of network depth on 3D U-Net-based dose prediction for cervical cancer radiotherapy
Authors: Wang Mingqing , Pan Yuxi , Zhang Xile , Yang Ruijie
Published: September 2024

Purpose

The 3D U-Net deep neural network structure is widely employed for dose prediction in radiotherapy. However, the attention to the network depth and its impact on the accuracy and robustness of dose prediction remains inadequate.

Methods

92 cervical cancer patients who underwent Volumetric Modulated Arc Therapy (VMAT) are geometrically augmented to investigate the effects of network depth on dose prediction by training and testing three different 3D U-Net structures with depths of 3, 4, and 5.

Results

For planning target volume (PTV), the differences between predicted and true values of D98, D99, and Homogeneity were statistically 1.00 ± 0.23, 0.32 ± 0.72, and -0.02 ± 0.02 for the model with a depth of 5, respectively. Compared to the other two models, these parameters were also better. For most of the organs at risk, the mean and maximum differences between the predicted values and the true values for the model with a depth of 5 were better than for the other two models.

Conclusions

The results reveal that the network model with a depth of 5 exhibits superior performance, albeit at the expense of the longest training time and maximum computational memory in the three models. A small server with two NVIDIA GeForce RTX 3090 GPUs with 24 G of memory was employed for this training. For the 3D U-Net model with a depth of more than 5 cannot be supported due to insufficient training memory, the 3D U-Net neural network with a depth of 5 is the commonly used and optimal choice for small servers.
Highly active antiretroviral therapy adherence among HIV-POSITIVE women in Southern Ethiopia
Authors: Demissie Alemayehu Abebe , Rensburg Elsie Janse van
Published: September 2024

Background

Adherence to Highly Active Antiretroviral Therapy (HAART) medication is the major predictor of HIV/AIDS treatment success. Poor adherence to HAART creates the risk of transmitting HIV, deteriorating health conditions, treatment failure, increased occurrences of drug-resistant HIV, morbidity and mortality. The objective of the study was to explore and describe factors influencing HAART adherence among HIV-positive women in Southern Ethiopia.

Methods

A hospital-based descriptive cross-sectional survey was used among 220 randomly selected respondents. Data was collected with a structured interview guide after each respondent had given consent to take part in the study. The collected data was entered into and analyzed by using the Statistical Package for Social Sciences (SPSS) software program version 27.

Results

The level of self-reported adherence (measured by dose) to HAART in the past 30 days was found to be 82.7%. In multivariate analysis, the divorced/separated HIV-positive women had poor adherence to their HAART medication as compared to those who were married [AOR: 2.94, 95% CI: (1.02–8.44)]. Respondents who used reminders in their medication were 75% less likely to be poorly adherent to their HAART medication than those who did not use reminders [AOR: 0.25, 95% CI: (0.06–0.97)]. Those who self-reported depression, perceived stigma, and low perceived susceptibility had poor adherence to their HAART than those who did not report depression, perceived stigma, and low perceived susceptibility [AOR:2.34, 95% CI: (1.01–5.42)], [AOR:2.37, 95% CI: (1.06–5.34)], and [AOR: 4.1, 95% CI: (1.53–11.1)] respectively. HIV-positive women who self-reported low perceived severity were poorly adherent to HAART than those who self-reported high perceived severity [AOR: 2.92, 95% CI: (1.14–7.47)].

Conclusion

Factors including being divorced/separated, not using reminders, depression, perceived stigma, perceived susceptibility, and perceived severity negatively impact HIV-positive women’s adherence to HAART.