bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal function during long-term therapy with rituximab in patients with systemic sclerosis
Authors: Starovoitova M. N. , Desinova O. V. , Ananyeva L. P. , Koneva O. A. , Garzanova L. A. , Ovsyannikova O. B. , Shayakhmetova R. U.
Published: October 2023

In systemic sclersis (SSc), different types of renal involvement occur. Their severity can range from asymptomatic deterioration of renal function to life-threatening damage, which is a complex therapeutic problem. Rituximab (RTM) has been used in the treatment of SSc and other autoimmune diseases with promising results, but its effect on renal function has not been adequately studied.

   Objective: to evaluate the renal function during complex therapy, including RTM, in patients with SSc over a long-term follow-up (at least 1 year).

   Material and methods. The study included 90 patients with SSc who were examined at least twice – before and 1–3.5 years after initiation of RTM treatment. Renal function was assessed by glomerular filtration rate (GFR) calculated according to the CKD-EPI formula. The stages of chronic kidney disease (CKD), blood pressure, daily proteinuria, skin score, activity, and indicators of lung function – forced vital capacity and diffusing capacity of the lungs – were also determined.

   Results and discussion. Against the background of complex therapy with RTM, there was a statistically significant decrease in GFR in the entire group of patients at the end of observation. On the other hand, renal function remained stable in the majority of patients with initially preserved GFR and there was a 25 % decrease – from 20 to 15 patients – in the number of patients with CKD. In more than half of the patients who initially had CKD, GFR increased (n = 11) or stabilized (n = 2) after therapy, and it decreased in a statistically insignificant manner in only 7 patients, whereas the development of a more advanced stage of CKD was observed in only 2 cases. The results of the treatment of 2 patients who had previously experienced scleroderma renal crisis (SRC) are reviewed in detail.

   Conclusion. In this study, there was no significant effect of RTM treatment on GFR and grade of CKD. Most patients had stable renal function; patients with an initial low grade of CKD showed a tendency toward stabilization of renal function. A significant decrease in GFR during long-term therapy noted in the entire patient group appears to be explained by an increase in renal insufficiency in patients with initially severe scleroderma renal damage, particularly due to SRC. Further studies on the effects of RTM therapy on renal function in patients with SSc are needed.
Urate-lowering therapy and the risk of developing type 2 diabetes mellitus in patients with gout (results of a prospective study)
Authors: Eliseev M. S. , Zhelyabina O. V.
Published: October 2023

Objective: to analyze the association between medications intake and the development of type 2 diabetes mellitus (T2DM) in patients with gout.

   Material and methods. The study included 444 patients with gout without T2DM. The median follow-up time was 5.9 [2.9; 8.7] years. The primary end point was the diagnosis of T2DM. At baseline, therapy was initiated or adjusted according to current guidelines. Medication use was recorded: allopurinol, febuxostat, diuretics, glucocorticoids (GC), canakinumab, for which the odds ratio (OR) of developing T2DM was calculated.

   Results and discussion. T2DM occurred in 108 (24.3 %) patients enrolled in the study. 405 patients completed the study. 311 (76.7 %) patients were taking urate-lowering drugs: 263 (90.7 %) allopurinol, 48 (9.3 %) febuxostat. The mean dose of allopurinol was 153.4 ± 28.4 mg/day, and that of febuxostat was 91.6 ± 12.1 mg/day. During treatment with febuxostat, the probability of developing T2DM was lower: OR 0.433 (95 % confidence interval, CI 0.188–0.996; p = 0.044). When diuretics were used OR was 2.212 (95 % CI 1.303–3.753; p = 0.003), GC – 1.566 (95 % CI 1.003–2.445; p = 0.048).

   Conclusion. Febuxostat use is associated with a lower likelihood of developing T2DM.
Dr hab. Jan Hauke, prof. UAM
Authors: Konecka-Szydłowska Barbara
Published: October 2023

Profesor Jan Hauke urodził się 1 października 1952 r. w Zagórowie. Jest z wykształcenia matematykiem. Kariera naukowa profesora związana jest z dwoma poznańskimi  uczelniami: Uniwersytetem im. Adama Mickiewicza (UAM) i Akademią Rolniczą (AR, obecnie Uniwersytet Przyrodniczy). Na UAM ukończył z wyróżnieniem studia matematyczne i uzyskał stopień magistra (1976 r.) oraz doktora nauk matematycznych (1984 r.). Stopień doktora habilitowanego nauk matematycznych otrzymał na Uniwersytecie im. Pawła Szafarika w Koszycach w roku 2013.
Trzy dekady kształtowania polskiej polityki regionalnej – refleksje, wnioski i rekomendacje
Authors: Churski Paweł
Published: October 2023

Celem opracowania jest prezentacja subiektywnych opinii autora na temat procesu kształtowania się polskiej polityki regionalnej w ostatnich trzech dekadach. Szczególną uwagę zwrócono na fakty i prawidłowości istotne z punktu widzenia obecnego i przyszłego funkcjonowania polskiej polityki regionalnej. Opracowanie podzielono na cztery zasadnicze części. W pierwszej zwrócono uwagę na znaczenie polityki regionalnej dla efektywnej realizacji krajowych polityk publicznych, w tym zwłaszcza polityki rozwoju. W drugiej części przedstawiono genezę i najważniejsze przemiany polskiego modelu polityki regionalnej w trzech dekadach jego funkcjonowania. W trzeciej omówiono naj- ważniejsze konsekwencje ostatniej reformy zmierzającej do wdrożenia w Polsce zintegrowanej polityki rozwoju, w podejściu zorientowanym terytorialnie. Całość opracowania zamykają wnioski i rekomendacje dotyczące najważniejszych wyzwań krajowej polityki regionalnej w Polsce.
High-temperature corrosion model of Incoloy 800H alloy connected with Ni-201 in MgCl2–KCl heat transfer fluid
Authors: Peng Yuxiang , Imam Muhammad A. , Reddy Ramana G.
Published: October 2023

Long-term dipping corrosion experiments on Incoloy 800H (800H) in molten eutectic MgCl2–KCl salt at 1,073 K with and without connection with Ni-201 alloy were carried out. While connecting with Ni-201 alloy, the corrosion rate of 800H was 4.47 ± 0.26 mg·cm−2·day−1 (10−3.55±0.02 A·cm−2). However, the corrosion rate for the 800H that was not connected to the Ni-201 alloy was 3.00 ± 0.27 mg·cm−2·day−1 (10−3.71±0.04 A·cm−2). Therefore, Ni-201 alloy accelerates the corrosion rate of 800H in the molten MgCl2–KCl salt while connecting to each other. In addition, based on the calculation of Gibbs energy of Ni–Fe–Cr alloy and exchange current density of 800H in MgCl2–KCl salt, a new Tafel model was developed to predict the corrosion rate of 800H alloys. The corrosion rate calculated by the new model is 10−3.74 A·cm−2, which agrees with the experimental data.
Excessive MALAT1 promotes the immunologic process of neuromyelitis optica spectrum disorder by upregulating BAFF expression
Authors: Chen Jing , Zhang Lijie , Lin Jingyu , Wang Zeng , Lin Aiyu
Published: October 2023

Increased B cell activating factor (BAFF) expression in patients with neuromyelitis optica spectrum disorder (NMOSD) is associated with B cell overstimulation, but the underlying mechanism remains unclear. This study aimed to reveal the emerging mechanisms that regulate BAFF expression in the inflammatory process of NMOSD. The results showed that the expression of miR-30b-5p was significantly decreased in NMOSD CD14+ monocytes compared with the normal control. Furthermore, we confirmed that metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) is an upstream target of miR-30b-5p, and it could act as a ceRNA and absorb miR-30b-5p with reduced expression of miR-30b-5p. The low expression of miR-30b-5p could not bind to BAFF messenger RNA (mRNA), which resulted in the overexpression of both BAFF mRNA and protein expression. Overexpression of BAFF could bind to the corresponding receptors on B cells, which may initiate activation and proliferation of B cells and increase their production of autoantibodies. Therefore, these findings interpreted that excessive MALAT1 expression in NMOSD mononuclear macrophages led to increased BAFF expression by targeting miR-30b-5p, which caused B cell autoimmune reaction and autoantibodies production, aggravated the disease progression of NMOSD.
From obsolete technology to performance instrument: new live presentations of the EMS Synthi 100
Authors: Morgan Frances
Published: October 2023

The presentation of electronic musical instruments in museum and other institutional contexts prompts a number of questions about the restoration of sound technologies, the reconstruction of musical practices and techniques, and past and present cultures of electronic music, among other topics. Drawing from research into the electronic musical instrument company and sound studio EMS London Ltd, which produced synthesizers and other devices during the 1970s, this paper outlines some examples of how an EMS synthesizer, the Synthi 100, has been restored and re-presented by academic, broadcasting and arts institutions in the last decade. Devised for compositional use in electronic music studios, in recent years the Synthi 100 has been used in concerts and broadcast media as an instrument for live performance. Focusing on some of these events, I ask how live performance is used to draw connections between electronic music’s past and present, as well as to attract new participants and audiences to concerts, exhibitions and broadcasts of electronic music.
Trevor Pinch’s legacy for media studies
Authors: Tosoni Simone
Published: October 2023

It is well known that throughout his long and brilliant career Trevor Pinch was a leading scholar in at least three research fields. In the sociology of scientific knowledge he was one of the most influential contributors, both alone and in collaboration with his mentor Harry Collins (see in particular Collins and Pinch, 1982; and Pinch 1985, 1986). He co-founded and developed the sociology of technology and the field of science and technology studies for which, in 2018, he was awarded the prestigious John Desmond Bernal Prize by the Society for Social Studies of Science (4S). Later in his career, he was a core player in the field of sound studies (see for example Pinch and Bijsterveld (eds), 2003, 2004, 2012), to which he was led by his work on the Moog synthesizer (Pinch and Trocco, 2002) and his passionate love for music. However, the work of Trevor Pinch, and in particular the Social Construction of Technology (SCOT) approach that he developed with Wiebe Bijker (Pinch and Bijker, 1984), has also been influential for many other neighbouring research fields to which he contributed only indirectly or episodically. This is the case for organisational studies, for example, or for studies of innovation. It is also the case for media studies. In what follows, as a media scholar, I represent the intellectual debt of my field to the work of Trevor Pinch. To do so, I will first clarify the role played by SCOT in the disciplinary tradition of media studies, in particular in the 1990s and at the beginning of the new century. I will then move my focus to lesser-known works by Trevor Pinch on mediated communication, which he sporadically addressed as part of his broader research interests (related, for example, to the practice of selling). My attempt will be to retrace the tenets of Pinch’s own take on media as they emerge both from these too rare interventions and from the methodological reflection he has dedicated to the topic. In my final remarks, I will draw on the two preceding sections to highlight some other possible points of crosspollination between the current field of media studies and Trevor Pinch’s work, that remain to be explored in depth.
Reanalysis of EphA3 Knock-In Double Maps in Mouse Suggests That Stochasticity in Topographic Map Formation Acts at the Retina Rather than between Competing Mechanisms at the Colliculus
Authors: Willshaw David J. , Gale Nicholas M.
Published: October 2023

It has been suggested that stochasticity acts in the formation of topographically ordered maps in the visual system through the opposing chemoaffinity and neural activity forces acting on the innervating nerve fibers being held in an unstable equilibrium. Evidence comes from the Islet2-EphA3 knock-in mouse, in which ∼50% of the retinal ganglion cells, distributed across the retina, acquire the EphA3 receptor, thus having an enhanced density of EphA which specifies retinotopic order along the rostrocaudal (RC) axis of the colliculus. Sampling EphA3 knock-in maps in heterozygotes at different positions along the mediolateral (ML) extent of the colliculus had found single 1D maps [as in wild types (WTs)], double maps (as in homozygous knock-ins) or both single and double maps. We constructed full 2D maps from the same mouse dataset. We found either single maps or maps where the visual field projects rostrally, with a part-projection more caudally to form a double map, the extent and location of this duplication varying considerably. Contrary to previous analyses, there was no strict demarcation between heterozygous and homozygous maps. These maps were replicated in a computational model where, as the level of EphA3 was increased, there was a smooth transition from single to double maps. Our results suggest that the diversity in these retinotopic maps has its origin in a variability over the retina in the effective amount of EphA3, such as through variability in gene expression or the proportion of EphA3+ retinal ganglion cells, rather than the result of competing mechanisms acting at the colliculus.
Dissociation of Centrally and Peripherally Induced Transcranial Magnetic Stimulation Effects in Nonhuman Primates
Authors: Perera Nipun D. , Alekseichuk Ivan , Shirinpour Sina , Wischnewski Miles , Linn Gary , Masiello Kurt , Butler Brent , Russ Brian E. , Schroeder Charles E. , Falchier Arnaud , Opitz Alexander
Published: October 2023

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation method that is rapidly growing in popularity for studying causal brain–behavior relationships. However, its dose-dependent centrally induced neural mechanisms and peripherally induced sensory costimulation effects remain debated. Understanding how TMS stimulation parameters affect brain responses is vital for the rational design of TMS protocols. Studying these mechanisms in humans is challenging because of the limited spatiotemporal resolution of available noninvasive neuroimaging methods. Here, we leverage invasive recordings of local field potentials in a male and a female nonhuman primate (rhesus macaque) to study TMS mesoscale responses. We demonstrate that early TMS-evoked potentials show a sigmoidal dose–response curve with stimulation intensity. We further show that stimulation responses are spatially specific. We use several control conditions to dissociate centrally induced neural responses from auditory and somatosensory coactivation. These results provide crucial evidence regarding TMS neural effects at the brain circuit level. Our findings are highly relevant for interpreting human TMS studies and biomarker developments for TMS target engagement in clinical applications.

SIGNIFICANCE STATEMENTTranscranial magnetic stimulation (TMS) is a widely used noninvasive brain stimulation method to stimulate the human brain. To advance its utility for clinical applications, a clear understanding of its underlying physiological mechanisms is crucial. Here, we perform invasive electrophysiological recordings in the nonhuman primate brain during TMS, achieving a spatiotemporal precision not available in human EEG experiments. We find that evoked potentials are dose dependent and spatially specific, and can be separated from peripheral stimulation effects. This means that TMS-evoked responses can indicate a direct physiological stimulation response. Our work has important implications for the interpretation of human TMS-EEG recordings and biomarker development.
The Common Good “In Question”? Notes on Christian Blum
Authors: Offe Claus
Published: October 2023

In response to Blum, this commentary highlights the core problem: the notion of a common good is indispensable on the one hand, yet nebulous, pluralistic, and ideologically biased on the other. We do not know the processes, in retrospect, that guarantee the common good as outcome. All we can posit is that the common good is the mitigation of “common bads” and that its beneficiaries are not just societies enshrined in the confines of the nation-state but other social collectives as well.
A selective journal
Authors: Pulverer Bernd
Published: October 2023

The stringent selection criteria applied at EMBO Reports result in the publication of around 16% of submitted papers. What do we select for and why is this a service to the scientific community? A counterpoint to EMBO Reports (2023) e58127.
RISING STARS: Mechanistic insights into maternal–fetal cross talk and islet beta-cell development
Authors: Jo Seokwon , Alejandro Emilyn U
Published: October 2023

The metabolic health trajectory of an individual is shaped as early as prepregnancy, during pregnancy, and lactation period. Both maternal nutrition and metabolic health status are critical factors in the programming of offspring toward an increased propensity to developing type 2 diabetes in adulthood. Pancreatic beta-cells, part of the endocrine islets, which are nutrient-sensitive tissues important for glucose metabolism, are primed early in life (the first 1000 days in humans) with limited plasticity later in life. This suggests the high importance of the developmental window of programming in utero and early in life. This review will focus on how changes to the maternal milieu increase offspring’s susceptibility to diabetes through changes in pancreatic beta-cell mass and function and discuss potential mechanisms by which placental-driven nutrient availability, hormones, exosomes, and immune alterations that may impact beta-cell development in utero, thereby affecting susceptibility to type 2 diabetes in adulthood.
Gestational exposure to cannabidiol leads to glucose intolerance in 3-month-old male offspring
Authors: Vanin Sebastian R , Lee Kendrick , Nashed Mina , Tse Brennan , Sarikahya Mohammed , Brar Sukham , Tomy Gregg , Lucas Amica-Mariae , Tomy Thane , Laviolette Steven R , Arany Edith J , Hardy Daniel B
Published: October 2023

Reports in North America suggest that up to 20% of young women (18–24 years) use cannabis during pregnancy. This is concerning given clinical studies indicate that maternal cannabis use is associated with fetal growth restriction and dysglycemia in the offspring. Preclinical studies demonstrated that prenatal exposure to Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis, in rat dams led to female-specific deficits in β-cell mass and glucose intolerance/insulin resistance. Yet to date, the contributions of cannabidiol (CBD), the primary nonpsychoactive compound in cannabis, remain elusive. This study aimed to define the effects of in utero cannabidiol (CBD) exposure on postnatal glucose regulation. Pregnant Wistar rat dams received daily intraperitoneal injections of either a vehicle solution or 3 mg/kg of CBD from gestational day (GD) 6 to parturition. CBD exposure did not lead to observable changes in maternal or neonatal outcomes; however, by 3 months of age male CBD-exposed offspring exhibited glucose intolerance despite no changes in pancreatic β/α-cell mass. Transcriptomic analysis on the livers of these CBD-exposed males revealed altered gene expression of circadian rhythm clock machinery, which is linked to systemic glucose intolerance. Furthermore, alterations in hepatic developmental and metabolic processes were also observed, suggesting gestational CBD exposure has a long-lasting detrimental effect on liver health throughout life. Collectively, these results indicate that exposure to CBD alone in pregnancy may be detrimental to the metabolic health of the offspring later in life.
Una mirada a los estudios del léxico aimara y normas para la elaboración del diccionario bilingüe
Authors: Huayhua Pari Felipe
Published: October 2023

Desde 1583, año en que sacerdotes españoles publicaron una Doctrina Christiana trilingüe, la lengua aimara ha tenido una larga tradición escrituraria: diccionarios, vocabularios, diccionarios o gramáticas, si no todos, han sido bilingües (español-quechua, español-aimara, portugués-guaraní). La estructura de un diccionario bilingüe debe ajustarse a las normas de la lexicografía moderna. No hacerlo puede originar un producto defectuoso, puesto que la preparación de un diccionario supone un cuidadoso tratamiento de aspectos gramaticales y léxicos.
La muerte de los métodos (“nouvelles vagues”) en la enseñanza de lengua(s)
Authors: Miranda Esquerre Luis
Published: October 2023

El uso de determinado método ha sido y es considerado como la solución para todos o por lo menos los principales problemas de la enseñanza de la primera o de la(s) segunda(s) lengua(s). Sin embargo, en la práctica, se puede decir, que todos han fracasado de alguna manera, tanto así, que ahora se habla de “la muerte de las metodologías”.
El inglés en el pregrado de San Marcos
Authors: Lozada Trimbath Minnie Eloisa
Published: October 2023

El estudio se centra en la concepción de los cursos de inglés en el nivel de pregrado por parte de Escuelas Académico Profesionales de la UNMSM y por los docentes de dichos cursos. Las fuentes empleadas son documentos de las Escuelas e ideas expresadas, en entrevistas, por sus autoridades. Se observa la influencia de la globalización en la implementación del inglés para algunas especialidades. Los resultados del estudio muestran, de un lado, la valoración que las Escuelas estudiadas hacen respecto de la utilidad del inglés en la actualidad y, de otro lado, la relación entre las expectativas de la Escuela y lo que el profesor a cargo del curso plantea. Destaca el interés de los Directores de Escuela por ayudar a que los alumnos avancen en su control de la lengua extranjera como habilidad necesaria para el siglo XXI.
Hacia la co-construcción de un dispositivo hipermedial dinámico para el proceso de escritura de artículos científicos en español de estudiantes de postgrado
Authors: Tramallino Carolina Paola , San Martín Patricia Silvana
Published: October 2023

Este artículo presenta los resultados de la primera etapa diagnóstica de un proyecto que tiene por objetivo general la co-construcción de un dispositivo hipermedial dinámico que colabore en procesos de escritura de artículos científicos en español. Dichos procesos se conciben como prácticas sociales vinculadas a un saber específico y, en este sentido, la investigación se encuadra en el desarrollo de prácticas educativas mediatizadas. Específicamente, se relevan las principales problemáticas que presentan 100 estudiantes de postgrado de una universidad argentina en los procesos de alfabetización científico-académica vinculados al desarrollo de diferentes competencias: comunicativa escrita, investigativa y digital. La metodología se adscribe a un enfoque cualitativo-cuantitativo para el análisis de las respuestas obtenidas mediante un cuestionario. Los resultados evidencian como principal problema la presentación y organización de la información: la falta de vocabulario académico/específico, como también dificultades para otorgarle cohesión al texto y estructurarlo de acuerdo a las características del género. En cuanto a las expectativas generadas ante herramientas digitales asistivas, se explicita que debe contar con foros y la posibilidad de obtener una asistencia de respuesta inmediata ante consultas surgidas en el proceso de escritura; por lo tanto, se sugiere la existencia de diccionarios de vocabulario académico, entre otras aplicaciones.
El caso beneficiario en quechua y en castellano
Authors: Calvo Julio
Published: October 2023

En este artículo se discute el papel del sufijo interno pragmático -pu- del quechua, en correlato con -mu-, y su compleja relación con el sufijo periférico casual -paq, con el fin de advertir sobre su disfuncionalidad sintáctico-pragmática, pese a cubrir semánticamente ambos el campo del Beneficiario. Se analizará también si existe un paralelismo semejante entre los pronombres átonos (me, te, se, lo…), el sufijo -ario y la preposición para en la lengua española. El contraste de ambas lenguas permitirá asegurar que la proyección pragmática es semejante en ambas, aunque morfológica y sintácticamente sean tan dispares.
La polisemia en el marco de la lingüística cognitiva
Authors: Mendes Magela Maíra
Published: October 2023

El fenómeno de la polisemia es una preocupación constante de los estudios cognitivos, ya que esta ciencia entiende que los significados de la palabra son típicamente polisémicos y se pueden representar mediante categorías conceptuales que se estructuran a partir de un prototipo central. Por tanto, la lingüística cognitiva explica la polisemia de las palabras a partir de los mecanismos cognitivos que la motivan. En este artículo, presentamos las maneras en que la polisemia se inserta en el paradigma de la lingüística cognitiva y los avances que esta corriente lingüística ha presentado para mostrar que la polisemia es una condición natural del lenguaje que está anclada en la experiencia corporal y social. En este trabajo, reafirmamos nuestra propuesta de investigar la polisemia como un fenómeno cognitivo en que se basa el procesamiento del lenguaje.
On Experience and Thinking to Come in the Late Schelling
Authors: Gelžinytė Brigita
Published: October 2023

This paper discusses late Schelling’s concept of experience and its significance regarding the relationship between thought and reality as presented in his Berlin lectures. The question is raised as to what extent his proposed transformation of the modern concept of experience is important for questioning the future of the contemporary philosophical discourse in the context of the “inaccessibility of experience,” as proposed by Benjamin and Agamben. The text argues that, instead of grounding the possibility of experience in the immanent or transcendental forms of subjectivity, the Schellingian alternative allows rethinking experience from the perspective of a radical future. By emphasizing the ontological dimension of experience, its inherent relationship with the question of freedom, and the problem of facticity of thinking itself, it becomes possible to place experience beyond the subject-object relation, immediacy, or sensory and objective cognition. This, it is also argued, allows us to reconsider the role of experience for metaphysics in the light of both post-Kantian and post-idealist forms of self-consciousness.
Political Philosophy as a Vocation
Authors: Bielskis Andrius
Published: October 2023

Publikuojame tekstą viešos paskaitos, kurią Mykolo Romerio universiteto profesorius Andrius Bielskis, Aristotelio ir kritinės teorijos studijų centro direktorius, Lietuvos nacionalinės Martyno Mažvydo bibliotekos kvietimu perskaitė 2023 m. balandžio 20 d. Paskaita, skaityta autoriaus 50 metų jubiliejaus proga, – reikšmingas Profesoriaus intelektualinės autobiografijos fragmentas, brėžiantis dar vieną akademinio maršruto variantą.Autorius dėkoja visiems, kas dalyvavo, klausėsi, skaitė ir komentavo jo mintis, ypač šeimos nariams – Severijai ir Nickui, atvykusiems iš Londono, Jolantai ir Samueliui Andriui, broliui Putinui, taip pat ir Nacionalinei Martyno Mažvydo bibliotekai už jos svetingumą
Non-Rating Recommender System for Choosing Tourist Destinations Using Artificial Neural Network
Authors: Arif Yunifa Miftachul , Wardani Dyah , Nurhayati Hani , Diah Norizan Mat
Published: October 2023

The development of tourist destinations in Batu City makes it hard for the tourists to decide their destinations. The recommender system is a solution that provides a lot of information or tourist attraction data. Collaborative filtering is often used in recommender systems. However, it has drawbacks; one of which is the cold-start problem, where the system cannot recommend items to new users. It was caused by the new user who had no history of rating on any item, or the system had no information. This study aims to apply a non-rated travel destination recommendation system to address the cold-start problem for new users. We use a multi-layer perceptron or artificial neural networks to overcome the problem by training user preference data to produce high training accuracy. Based on four experiments in the training data, the network architecture shows 5 – 7 – 5 – 3 –14, which is the highest accuracy. The architecture uses five variables as inputs and three hidden layers, with each layer was activated using the ReLU activation function. The output layer produces 14 binary outputs and is activated using the sigmoid activation function. The system can give recommendations to new users using feedforward from test data with updated values in weights and biases. The test results from 46 test data showed an accuracy of 67.235%.
Analysis of the Use of Artificial Neural Network Models in Predicting Bitcoin Prices
Authors: Sahi Muhammad , Faisal Muhammad , Arif Yunifa Miftachul , Crysdian Cahyo
Published: October 2023

Bitcoin is one of the fastest-growing digital currencies or cryptocurrencies in the world. However, the highly volatile Bitcoin price poses a very extreme risk for traders investing in cryptocurrencies, especially Bitcoin. To anticipate these risks, a prediction system is needed to predict the fluctuations in cryptocurrency prices. Artificial Neural Network (ANN) is a relatively new model discovered and can solve many complex problems because the way it works mimics human nerve cells. ANN has the advantage of being able to describe both linear and non-linear models with a fairly wide range. This research aims to determine the best performance and level of accuracy of the ANN model using the Back-Propagation Neural Network (BPNN) algorithm in predicting Bitcoin prices. This study uses Bitcoin price data for the period 2020 to 2023 taken from the CoinDesk market. The results of this study indicate that the ANN model produces the best performance in the form of four input nodes, 12 hidden nodes, and one output node (4-12-1) with an accuracy rate of around 3.0617175%.
Diel vertical migration and frontal variability of acoustic backscatter in the Balearic Sea
Authors:   , Cheslack Helena R.
Published: October 2023

Acoustic Doppler current profilers (ADCPs) use active sonar to measure current velocities by measuring the sound returned by scatterers (most often zooplankton) in the water column. The volume of scatterers, or echo intensity, has been used to measure the abundance of zooplankton and characterize diel vertical migration (DVM). DVM is the mass vertical movement of zooplankton and fish between the surface waters where they feed at night, and the mesopelagic zone where they avoid predators during the day; it is considered the largest migration of biomass on Earth, happens in every ocean, and is important to the global carbon cycle. This thesis uses a combination of data that I helped acquire during the Office of Naval Research-funded CALYPSO 2022 field campaign in the Balearic Sea. Acoustic backscatter from a 38kHz ADCP and a 150kHz ADCP is translated into mean volume backscattering strength (MVBS) to characterize the sound scattering layers (SSLs) in the Balearic Sea. WireWalker data is used to model subsurface light. The MVBS is compared to measurements of temperature, salinity, chlorophyll concentration, and dissolved oxygen (DO) from the EcoCTD, a towed instrument that simultaneously measures hydrographic and biological parameters. The analysis reveals one permanent scattering layer at 300m – 600m and two migrating scattering layers in the top 50m and between 100m – 300m. The layers are likely made up of zooplankton like krill and pteropods and pelagic fish. The speed of vertical migration ranges from 1 – 11cms−1, and migrators are follow isolumes during migration times. DVM has the strongest effect on backscatter anomalies, but during daytime and nighttime, DO is most correlated with the backscatter anomaly. We demonstrate that ADCPS can be used to characterize SSLs and DVM. The uniquely co-located EcoCTD data from CALYPSO enables us to compare the frontal variability in scatterers to variability in biological and physical parameters. Characterizing the SSLs, DVM, and frontal variability of acoustic backscatter furthers understanding of the global carbon cycle.
„Samorządna Rzeczpospolita” – ideowy drogowskaz „Solidarności”
Authors:   Uniwersytet Warmińsko-Mazurski w Olsztynie, Fabiszewski Wojciech
Published: October 2023

In the autumn of 1981, the 1st National Congress of Delegates of the Independent Self-Governing Trade Union “Solidarity” took place, which democratically elected its authorities and adopted a modern program. The program covered all areas of life. Its basis was supposed to be workers’ self-government. The gradual implementation of the program was to lead to the democratization of the system through free elections at the regional and then national level. The introduction of martial law made it impossible to start reforms and delayed the political transformation. During the system change in 1989, during the Round Table talks, some of the provisions contained in the “Solidarity” program were used. We can acknowledge that the 1st National Congress of Solidarity Delegates played a role in the process of political and social transformation in Poland. Further implementation of the postulates was possible in a democratic system.
Carreira e ambição política na Câmara dos Deputados do Brasil: uma proposta de análise tridimensional
Authors: Sainz Nilton , Codato Adriano
Published: October 2023

Este estudo emprega um modelo tridimensional de análise para examinar os efeitos (1) das regras institucionais, (2) do perfil sociopolítico e (3) do grau de profissionalização política dos parlamentares brasileiros nas suas escolhas de carreira. Os dados para o estudo dos deputados federais eleitos em 2014 foram obtidos do Tribunal Superior Eleitoral. Para analisar os efeitos combinados de variáveis de tipo institucional, social e profissional sobre a ambição política foram utilizados modelos de regressão logística binomial. Foram analisadas suas opções eleitorais nas eleições de 2016 e 2018. Os resultados revelam interações complexas entre essas dimensões, proporcionando novos insights sobre os padrões de escolha de carreira. Observa-se uma relação significativa entre ambição e status político. Parlamentares com trajetórias mais consolidadas têm maiores chances de optar por ambição progressiva. Além disso, foram identificadas variações nas escolhas de carreira e no sucesso eleitoral dependendo do nível de governo que ambicionam e do tipo de sistema eleitoral (majoritário ou proporcional) pelo qual competem. Quanto às intersecções entre ambição política e perfil social, apenas o baixo status educacional impacta em ambição regressiva. Esses achados contribuem para uma compreensão mais abrangente do fenômeno da ambição política, considerando dimensões pouco exploradas na literatura, como a profissionalização política e o perfil social das elites parlamentares.
Experimental investigation of gas migration behaviour in unsaturated sand–clay mixtures
Authors: Zhang Kangjian , Zhang Zhiqiang , Li Yuxi , Hu Zhechuan
Published: October 2023

Understanding gas migration behaviours in unsaturated sand–clay mixtures is of great importance to design and construction involving applications of shield-cutting-tool replacement using pressure. A gas permeability test apparatus for unsaturated soil was upgraded to investigate gas migration behaviours further. A series of gas, liquid and solid three-phase coupling gas injection tests were performed on unsaturated clay under different moisture contents and sand–clay ratios. There are three stages of gas migration in unsaturated sand–clay: steep drop stage, transition stage and stability stage. In unsaturated sand–clay with low moisture contents and gas pressures, gas migration is affected primarily by the slippage effect. When the gas pressure is greater than 300 kPa, the permeability remains nearly unchanged. In this case, the gas permeability of the soil sample is affected primarily by the internal structural characteristics of the unsaturated soil sample and those of the shrinkage film. The ideal gas permeability of the soil used in actual engineering and the empirical formula for calculating the pressure of the shield pressure-holding system are summarised.
A thermomechanical model for argillaceous hard soils–weak rocks: application to THM simulation of deep excavations in claystone
Authors: Tourchi Saeed , Mánica Miguel A. , Gens Antonio , Vaunat Jean , Vu Minh-Ngoc , Armand Gilles
Published: October 2023

The paper presents the enhancement of an existing constitutive model for argillaceous hard soils–weak rocks to incorporate non-isothermal conditions, to be used in coupled thermo-hydro-mechanical (THM) simulations of underground excavations subjected to temperature variations within the context of deep geological nuclear waste disposal. The proposed thermo-elastoplastic extension accounts for the effect of temperature on the yield and plastic potential functions and on the elastic stiffness. The resulting model is validated through the simulation of relevant non-isothermal laboratory tests reported in the literature. The model is then applied to the coupled THM simulation of an in situ heating test conducted at the Meuse/Haute-Marne underground research laboratory in Bure, France, excavated in the Callovo-Oxfordian claystone. Results show that the incorporation of thermal effects into the constitutive description of the host rock plays a significant role in the behaviour of the excavation when subjected to thermal loading, particularly in the evolution of the excavation fractured zone.
Forever Conquered: The Changing Role of Vikings in Modern and Contemporary Anglo-American Culture
Authors: Kramer Miles
Published: October 2023

Ever since their disruption and subsequent invasion of the British Isles in the early Middle Ages, the Scandinavian raiders known as 'Vikings' have had a significant presence in English culture and its self-perceived past. Anglo-American popular culture has become the primary home of the subject in the centuries since, with the Vikings appearing as everything from lecherous, bloodthirsty pirates to proud Christian heroes in the media of the English West. A timeline of this evolution can be drawn between Victorian era England and modern-day America, with works such as Walter Scott's The Pirate, Richard Fleischer's formative The Vikings, John McTiernan's turn-of-the-century The 13th Warrior, and DreamWorks Animation's highly successful How to Train Your Dragon presenting compelling examples of the conceptual transformation that the Viking image has undergone. The popularity of Vikings in media and the form in which they have been used also reflects the way that literary and visual symbols have contributed to the spread and impact of major sociocultural and political movements throughout this period. As a result, the study of the Vikings' presence in Victorian and post-Victorian popular media is also the study of the Vikings' importance in the Anglo-American zeitgeist, enabling us to see the degree to which differing national climates have both shaped and platformed the Viking image across the last two hundred years.
“License to Do Evil in the Name of Good”: The Legacy of Anti-Electoral Violence and Organizational Success During the Wilmington Coup of 1898
Authors: Miller Jesse Joseph
Published: October 2023

This paper seeks to analyze the impact of local political actors on the development of the Wilmington coup of 1898, an event that stands out in American history due to the violent overthrow of a sitting city government. The event has been studied more in recent decades by Prather, Gilmore, and the state of North Carolina, and they tend to focus on the aspects of race and gender that pervaded the buildup to the coup against a government with African-American civic participation. I build on the existing scholarship to argue that, while white supremacy and gender hierarchy in the South were important to understand why the participants were convinced to engage in political violence more broadly, the influence that a group of dedicated conspiracists had on the events in Wilmington shows that it took the proper urging and coordination for the coup to unfold and succeed at all. Through comprehensive military planning and the nimble adaptation of rhetoric, Wilmington succeeded where other insurrections failed. I will also argue that the conditions and tactics that allowed Wilmington to succeed can be found in modern acts of political violence, such as the Capitol Insurrection. 
Redefining Revolution: Evaluating the Political and Social Changes of the American Revolutionary Period, 1765-1820
Authors: Halbach Max
Published: October 2023

Adding to the conversation of evaluating the extent to which the American Revolution altered the lives of people living in Britain's former Atlantic colonies in North America, this paper briefly explores how the American Revolution was a transformative event for Native Americans, Black people, and women.
The Woman King’s Erasure of The Kingdom of Dahomey’s Involvement in the Transatlantic Slave Trade
Authors: Sansone Emily Marie , Ali Ayshe Nur
Published: October 2023

In Gina Prince-Bythewood's, The Woman King, the historical fact that the Kingdom of Dahomey participated in the Transatlantic slave trade is wrongly overlooked, which caused criticism and confusion for audiences watching. Throughout the film, Dahomey is wrongly misunderstood to be a liberator for enslaved individuals, but looking further into historical documentation illustrates Dahomey's involvement and benefit from these horrifying experiences. Although the creators engage the audience with a fully female army, they lack transparency surrounding slavery and Dahomey's involvement. 
Políticas de comunicación e inteligencia artificial: nuevos desafíos
Authors: Seijas Raquel
Published: October 2023

La inteligencia artificial presenta importantes desafíos; es necesario que gobiernos e instituciones evalúen sus consecuencias y efectos para abordar los cambios que implica. El objetivo de este estudio es comparar las regulaciones sobre inteligencia artificial en España, la Unión Europea y Estados Unidos, y examinar cómo podrían afectar la formulación de políticas de comunicación y, en última instancia, a los medios de comunicación. La metodología utilizada incluye el estudio documental, para localizar hallazgos clave, y el análisis comparativo de las regulaciones sobre inteligencia artificial. La inclusión de la inteligencia artificial en los medios de comunicación requerirá control sobre decisiones y efectos, lo cual plantea nuevos interrogantes sobre la formulación de políticas de comunicación.
Bilimsel Akıl Yürütme Temelli Eğitim Etkinliklerinin 4 ve 5 Yaş Çocuklarının Bakış Açısı Alma Becerilerine Etkisi
Authors: ŞAHİN Zeynep Merve , BAŞARA BAYDİLEK Nisa
Published: October 2023

Bu çalışma bilimsel akıl yürütme temelli eğitim etkinliklerinin 4 ve 5 yaş çocuklarının bakış açısı alma becerilerine etkisini incelemek amacıyla gerçekleştirilmiştir. Araştırmada nicel araştırma desenlerinden ön test-son test kontrol gruplu yarı deneysel desen tercih edilmiştir. Çocuklar için Bakış Açısı Alma Testi (ÇBT), araştırmacı tarafından hazırlanan bilimsel akıl yürütme derecelendirme envanteri ve kişisel bilgi formu ile veriler toplanmıştır. Verilerin analizinde Wilcoxon İşaretli Sıralar testi, Mann Whitney U testi kullanılmıştır. 4 yaş grubunda 40 çocuk, 5 yaş grubunda 53 çocukla çalışılmıştır. Deney grubuyla 8 hafta boyunca haftada 2 gün çalışılmıştır. Plasebo grubundaki çocuklarla etkileşime girmek amacıyla masal saatinde ve öğretmenin belirlediği etkinliklere katılım sağlanmıştır. Kontrol grubuna herhangi bir müdahalede bulunulmamıştır. Araştırmanın sonucuna göre 4 yaş deney grubundaki ve 5 yaş deney grubundaki çocukların ÇBT ön test-son test puanları arasında algısal bakış açısı (perspektif) alma, duygusal bakış açısı alma, bilişsel bakış açısı alma ve test toplam puanlarında istatistiksel olarak anlamlı bir fark olduğu belirlenmiştir (p
Belirsizliklerin yorulma ömrü üzerindeki etkilerinin aralık sayılar kullanarak analizi
Authors: ERDÖLEN Ayşe , KÜTÜĞ Zafer
Published: October 2023

Büyüklüğü zamanla değişen yüklemeler altında mühendislik yapılarındaki küçük yorulma çatlakları, daha sonrasında gelişerek ani ve yıkıcı hasarların oluşması gibi tehlikeli sonuçlara ulaşabilmektedir. Yorulma Çatlak Büyümesi (FCG) ömrünün güvenli bir aralıkta tanımlanması, bir sistemin işletme yükleri altında emniyetli bir şekilde çalıştırılması için son derece önemlidir. Bu sayede doğru bir bakım ve servis aralığının tespiti öngörülerek söz konusu hasarların aniden ortaya çıkması önlenebilmektedir. Diğer taraftan tasarım sürecinde yorulma performansının belirlenmesinde, yetersiz bilgilerden ve genellemelerden kaynaklanan bazı belirsizlikler söz konudur. Bu çalışmada, kırılma mekaniğine dayalı yorulma çatlak büyümesi tahmininde yer alan, malzeme, yük ve geometri parametrelerindeki belirsizliklerin etkileri Interval Analizi Yöntemini (Aralık Sayılar) kullanılarak sunulmuştur. Dolayısıyla, farklı türden parametrelerin belirsizlikleri dikkate alınarak, FCG life için alt ve üst sınırları ile belirlenmiş güvenli aralık değerlerin elde edilmesi hedeflenmektedir. Önerilen yöntem, EN-GJS-600-3 malzeme özelliklerine sahip bir plakanın yorulma çatlağı büyüme ömrünün tahminine uygulanmıştır. Matematiksel işlemlerde MatLab ara yüzü için geliştirilen interval toolboxlar kullanılarak, interval aritmetiğine özgün olarak hazırlanan bilgisayar kodu ile birlikte çalışması sağlanmıştır.
A new guideline for geological maps with QGIS
Authors: Erharter Georg H. , Steinbichler Mathias , Eder Markus , Hintersberger Esther , Jaeger Dominik
Published: October 2023

Being able to create digital geological maps has become a basic requirement for the skillset of today’s geologists. QGIS is a geographical information system that receives increasing popularity due to its user-friendliness and the fact that it is an open access software. This contribution provides an update and extension to a previously published software guideline that gives a stepwise explanation on how to create a geological map with QGIS. The article serves as a brief overview of the guideline through an illustrated example. The guideline itself is published as a supplement to this paper. Within six sections, the guideline explains how to create a geological map with QGIS: 1. Introduction, 2. Download and installation, 3. Basemaps, 4. Map drawing, 5. Plugins, 6. Layouts. The aim is to instruct geologists who are completely inexperienced with digital map creation as well as provide specific information for more advanced users. In general, providing software guidelines for the geological community is an important step towards increasing geologists’ digital proficiency and to keep up with today’s fast paced developments in digitalization.