bluuebunny/crossref_metadata_2025 huggingface dataset:
City Newcomers’ Adaptation to Urban Life, Personal Well-Being, and Social Support
Authors: Xia Tianqiong , Wang Yifu , Lin Qiyi
Published: September 2018

We evaluated the level of adaptation of city newcomers (CNs) to urban life in China, and their personal well-being, and explored the mediating effect of social support on the relationship between these variables. We used a 2-stage sampling method to recruit 314 participants who completed
the Adaptation to Urban Life Scale, Social Support Scale, and Personal Well-Being Scale. Structural equation modeling was used to test full and partial mediation effects. Findings showed that there was a significant correlation between the extent of CNs’ positive adaptation to urban
life and their personal well-being. In addition, social support was beneficial for CNs’ personal well-being, and partially mediated the relationship between CNs’ adaptation to urban life and personal well-being. In addition, the adaptation to urban life dimensions of employment
prospects, living conditions, and urban environment predicted CNs’ personal well-being. Implications of the findings are discussed, along with directions for future research.
Analysis of Economic and Business Factors Influencing Disruptive Innovation in Telehealth
Authors: Jorge Millan Jorge Millan , Yunda PhD Leonardo , Valencia PhD Andrés
Published: September 2018

Objective. Analysis of economic and business factors influencing disruption innovation in healthcare taking as a reference Telehealth systems and technologies. Methods. Analysis of economic and business decision factors that influence the adoption of new technologies are qualitatively analyzed using as a case example Telehealth systems. Results. Main factors for the adoption of new technologies in healthcare are identified and analyzed. Factors include new technology adoption cost, usability, perceived value, competitive systems, old systems competitivecost and performance, and type of users, between others.
Anemias ferropénicas asociadas a hemoglobinopatías en comunidades afrodescendientes en Colombia
Authors: Castillo Bohórquez Martha , Mora Bautista Ana Isabel , Oliveros Rozo Ana Lucia
Published: September 2018

Objetivo. Determinar la presencia de anemias ferropénicas asociadas a hemoglobinopatías enafrodescendientes adultos colombianos habitantes de la ciudad de Tumaco, en el Departamentode Nariño y residentes de la localidad de Engativá, en Bogotá.Metodología. Las pruebas consideradas en este estudio incluyeron la valoración del hemogramaautomatizado, frotis de sangre periférica, proteína C reactiva, ferritina Sérica, electroforesis dehemoglobina, en 103 participantes, 23 de la comunidad afrodescendiente de Engativá y 80 deTumaco. Esta investigación es de tipo descriptivo; por su enfoque metodológico es cuantitativa ytransversal; estructurada, no experimental y correlacional, cuyo diseño muestral es estratificado,no probabilístico de tipo intencional.Resultados. La población en estudio perteneciente a la comunidad afrodescendiente ubicadasen las localidades de Tumaco, Nariño y Engativá de la ciudad de Bogotá, presentó anemia en lapoblación femenina 28.6 % y la masculina 16.0 %. Se observó que el 9.7 % de la población enestudio, presenta hemoglobina y ferritina baja, relacionado con anemia por deficiencia de hierroy el 13.6 % presenta una deficiencia subclínica de hierro al presentar deficiencia de hierro sinanemia. Con respecto a los resultados de electroforesis de hemoglobina, el 13.6 % se evidenciócon hemoglobina A2 aumentada, con posible asociación a talasemias o hemoglobinopatía C, el0.98 % con hemoglobina S, el 0.98 % con rasgo de hemoglobina S y el 84.5 % con hemoglobinaA. El 0.97 % de la población presenta ferritina baja con hemoglobina A2 aumentada, mostrandodeficiencia de hierro asociada con posible hemoglobina C o talasemia y el 0.97 % de la poblaciónpresenta ferritina baja con hemoglobina S. Otro hallazgo importante es la presencia de valoresbajos de ferritina en el 17.8 % de las mujeres y el 4.95 % en hombres. Las variables cuantitativasse analizaron con medidas de tendencia central como el promedio y se describieron por medio defrecuencias absolutas y porcentuales.
La formación de biopelículas y la calidad del agua en la consulta odontológica
Authors: Campuzano Silvia , Jiménez Laura , Hernández Diana M
Published: September 2018

Objetivo. Recuperar y analizar la presencia de bacterias formadoras de biopelículas en las mangueras de la jeringa triple y de la pieza de mano que distribuyen el agua a las unidades dentales de la Fundación Universitaria San Martin. Método. Se realizó un estudio descriptivo de corte transversal con muestreo probabilístico. Se estudiaron las bacterias presentes en el agua recolectada en la jeringa triple y la pieza de mano, las cuales fueron seleccionadas al ser los instrumentos por los cuales transita el agua que entrará en contacto con el paciente. Se tomaron muestras antes y después de la consulta, de la jeringa triple con solo agua, con agua–aire y la pieza de mano. Se realizaron cultivos por filtración por membrana en medios Endo, Cetrimide y Sangre Azida. Resultados. Se encontraron 84 % de muestras positivas para cocos Gram positivos, mientras que el 8 % de las muestras presentaban aislamientos de bacilos Gram negativos, representado en E coli y P aeruginosa. La flora Gram positiva estuvo representada por Staphylococcus hominis y Staphylococcus epidermidis.
Amniocentesis precoz y biopsia de vellosidad corial. Pérdidas fetales y anomalías congénitas en un grupo de gestantes brasileñas
Authors: Bernal Luz Mery , Bernal María Consuelo , Gollop Thomaz
Published: September 2018

En el Instituto de Medicina Fetal y Genética Humana de São Paulo se ofrecen, a las gestantes que tienen un riesgo aumentado para anomalías cromosómicas, diferentes técnicas, entre ellas, la Biopsia de Vellosidad Corial Transabdominal (BVCTA) y la Amniocentesis Precoz (AP). El objetivo del presente estudio es realizar una comparación de la frecuencia de pérdidas fetales y anomalías congénitas presentadas en cada uno de los procedimientos, ambos realizados por los mismos operadores, en la misma edad gestacional (12-14 6/7 semanas) y bajo un abordaje transabdominal. Fueron analizadas retrospectivamente 432 AP y 418 BVCTA. Todos los procedimientos de colecta fueron monitorizados por ultrasonografía. La frecuencia de pérdidas fetales espontáneas fue del 4,9 % en AP y de 5,3 % en BVCTA, una diferencia no significativa. No se encontraron diferencias significativas entre los dos procedimientos al comparar las frecuencias de pérdidas en cada semana de gestación. Sangrado y pérdida de líquido amniótico fueron más frecuentes en AP que en la BVCTA. Esa diferencia fue significativa en el caso de la pérdida de líquido amniótico. En algunoscasos este hallazgo se relacionó con pérdida fetal. La incidencia de prematuridad y bajo peso al nacimiento no difirió significativamente entre los dos procedimientos. La mayor frecuencia de problemas respiratorios registrada en AP no fue significativa en comparación con BVCTA. No se observó diferencia significativa en la incidencia de anomalías músculo-esqueléticas. La amniocentesis después de catorce semanas presenta un bajo riesgo de pérdida fetal o anomalías congénitas. La BVCTA, debe ser realizada alrededor de la semana doce de gestación.
Resistencia microbiana desde una perspectiva metagenómica
Authors: Ospino Bejarano K A , Castilla Pérez MG G , Sánchez-Mora R M
Published: September 2018

Objetivo. La finalidad de esta revisión es abarcar la temática relacionada con los genes de resistencia a antibióticos, sus orígenes, reservorios y movimientos en los diferentes hábitats mediante la metagenómica funcional que permite aislar, identificar y analizar estos genes, así como el impacto que tienen en salud pública. Durante los últimos años se ha visto un gran avance en la microbiología, una de las grandes limitaciones a las que se venían enfrentado los microbiólogos era no poder acceder a la totalidad de los microorganismos que habitan el planeta. Gracias al desarrollo de diferentes disciplinas como la metagenómica se ha logrado tener el acceso a estos microorganismos. Metodología. La importancia de la metagenómica en la resistencia microbiana radica en que, actualmente, solo el 1 % de los microorganismos que habitan el suelo pueden ser estudiados por técnicas convencionales de microbiología, quedando alrededor del 99 % de estos sin estudiar. Al mitigar este gran inconveniente, la metagenómica permite el estudio de la microbiota del suelo en su totalidad generando nuevo conocimiento e información relevante en diferentes campos científicos. Resultados. Mediante la metagenómica funcional se ha podido determinar que el suelo puede ser un posible reservorio de determinantes de resistencia microbiana, debido a que la microbiota que allí habita contiene en su material genético genes de resistencia a antibióticos que confieren resistencia a un amplio espectro de antibióticos utilizados en terapia humana de forma indiscriminada y además tienen todos los mecanismos de resistencia conocidos, algunos de estos genes son generados por presión selectiva ante diferentes agentes presentes en su medio y otros son genes constitutivos que cumplen con funciones significativas en su hábitat. El gran impacto que tienen estos hallazgos está dado en que pueden representar un posible riesgo en salud pública si se adquieren por los patógenos humanos.
Infiltración versus remineralización: Estudio preliminar ex-vivo de alternativas para el tratamiento no invasivo de las lesiones por caries con materiales bioactivos
Authors: Sainz Aja M , Ribba LI , Cabral JR , Molina JF
Published: September 2018

El objetivo fue determinar profundidad de penetración en dentina cariada artificial y cambios en su dureza superficial de dos protocolos de tratamiento: 1- infiltración del tejido cariado con resina fluida modificada con nanopartículas de óxido de cinc y 2- remineralización con fluoruro di-amino de plata. Para tal fin se prepararon láminas de terceros molares sanos de 4 mm de espesor en los cuales se generaron lesiones artificiales de caries sobre la superficie oclusal de la muestra, en un área de 6x6 mm. Las muestras se dividieron en dos grupos de tratamiento. Cada muestra fue seccionada en tres porciones de superficie cariada y una sección adicional de dentina intacta. En dos de las secciones con caries se aplicó el protocolo de tratamiento correspondiente. De esas dos secciones, una fue utilizada para realizar un mapeo en microscopio electrónico de barrido (MEB), identificando la presencia de plata (Ag) o cinc (Zn). En la porción restante que recibió tratamiento se evaluó su dureza superficial y se la comparó con la parte que no recibió tratamiento y con la sección adicional de dentina intacta. La dureza superficial se valoró mediante diagramas de fuerza obtenidos por un microscopio de fuerza atómica (AFM). Los resultados evidenciaron una penetración significativa de Ag y presencia superficial de Zn en las muestras. Los diagramas de fuerza mostraron los valores más elevados en las superficies tratadas con Fluoruro de plata, seguidas por la dentina intacta y las superficies que recibieron la resina con nanopartículas de cinc. La dentina cariada presentó valores asociados a menor dureza. Se concluyó que ambos tratamientos pueden mejorar las propiedades mecánicas superficiales del tejido, pero se necesitan estudios más específicos para determinar la profundidad de penetración en dentina afectada por caries.
Nanotecnología en Odontología: Aspectos generales y posibles aplicaciones.
Authors: Molina GF , Palma SD
Published: September 2018

Las innovaciones tecnológicas en Odontología procuran desde las Nanociencias dar solución a una diversidad de problemas en el cuidado de la salud bucal. La obtención de partículas a escala atómica se logra por dos vías: reduciendo una partícula hasta lograr un tamaño nanométrico o ensamblando nanoelementos con características y propiedades específicas. Estos pequeños compuestos tienen potenciales aplicaciones en el diagnóstico, prevención y tratamiento de patologías orales desde caries, enfermedad periodontal, maloclusiones, lesiones en tejidos blandos y hasta posibles indicaciones para mejorar la estética dental y el comportamiento mecánico, biológico y óptico de materiales restauradores. Algunos desarrollos se encuentran consolidados con etapas exitosas de experimentación y aplicación clínica en tanto que otros se avizoran con expectativas de cambios revolucionarios, como aquellas relacionadas a la ingeniería tisular.
Ventajas y riesgos del uso de pastas dentales con nanotecnologías
Authors: Rocamundi M , Lagoner A , Lasca Juncal A , Pollo C , Reston Fradejas ML , Chiadeh S , Cerioni GI , Lupica Castro D , Daher M , Di Genaro S
Published: September 2018

El presente artículo de actualización analiza las ventajas y riesgos del uso de nanopartículas en pastas dentales. La nanotecnología puede mejorar sus propiedades ayudando al proceso de remineralización del diente, controlar el crecimiento bacteriano o proporcionar minerales para mejorar el control del pH. Con este fin se han agregado: nanohidroxiapatita, nanocalcio, fosfato de calcio, trimetafosfato de sodio, nanopartículas de plata, quitosán, entre otras. Por otro lado, se han descripto algunos efectos nocivos de estas nanotecnologías, lo que nos motiva a intensificar su estudio. Conclusiones: La nano-odontología ha otorgado nuevas herramientas para la atención preventiva de la salud. La toxicidad oral para los nanodentífricos es baja, pero algunos pueden llegar al intestino, y a través de él a la circulación sanguínea y causar disturbios sistémicos. Es necesario profundizar las investigaciones en estos materiales, a fin de mejorar sus efectos beneficiosos, e identificar y eliminar sus riesgos
The case of transhumanism: The possibility of application of Nietzsche’s ethics and critique of morality today
Authors: Agatonovic Milos
Published: September 2018

Transhumanism, the movement that promotes radical enhancement by
non-traditional means based in scientific and technological advances, has
contributed to contemporary interest in Nietzsche?s philosophy. In this
paper, we are going to claim that transhumanists? references to Nietzsche?s
philosophy are unfounded. Moreover, we will make a few remarks about
Nietzsche?s ethical doctrine in order to show that his conception of
enhancement, contrary to transhumanist conceptions, relies on traditional
means, such as upbringing and education. Although Nietzsche?s positive
ethical doctrines cannot be used to justify transhumanist goals, his
critique of morality can be used as a critique of the transhumanist
conceptions of human enhancement.
“Eternal Ballet” In Plato’s Cave
Authors: Perovic Drago
Published: September 2018

This exposition attempts to explore the question of the relationship between thinking and reality in the current technico-technological disappearance-in-appearance. All fundamental philosophical questions are covertly related with it, and above all the question of the possibility of thinking ?from? or ?beyond? the reality which appears/disappears. The contemporary debate thus returns to the transcendent-immanent character of the thought which, as a question of possible justification of philosophical knowledge, can be compared with its traditional forms and modes of execution in spite of the new situation in its (dis)appearance. The field of this dance is a new ?cave wall? that stages technics and technology in their powerful performance.
Computational, antimicrobial, DNA binding and anticancer activities of pyrimidine incorporated ligand and its copper(II) and zinc(II) complexes
Authors: Sankarganesh Murugesan , Revathi Nagaraj , Raja Jeyaraj , Sakthikumar Karunganathan , Vinoth Kumar , Rajesh Jegathalaprathaban , Rajalakshmi Manikkam , Mitu Liviu
Published: September 2018

In this research article, the synthesis, structural characterization, and biological, DNA binding and anticancer properties of pyrimidine incorporated Schiff base ligand L and its [CuL2](ClO4)2 (1) and [ZnL2](ClO4)2 (2) complexes are reported. The isolated complexes 1 and 2 have significant antibacterial and antifungal properties, greater than those of ligand L. The interaction between protein and L were analyzed by an in silico method. The intercalative binding of the prepared compounds was proved from electronic absorption, fluorometric, cyclic voltammetric and viscometric methods. The calculated binding parameters such as, Kb (2.65?103, L; 7.74?103, 1 and 2.99?103, 2); Ksv (3.30?103, L; 4.31?103, 1 and 3.89?103, 2), and Kapp (2.15?105, L; 3.30?105, 1 and 2.82?105, 2) indicted that complex 1 has better interaction ability than L and complex 2. The in vitro anticancer properties of L, and complexes 1 and 2 against human cancer (MCF-7, HeLa and HEp-2) and normal (NHDF) cell lines were determined by the MTT assay method. The obtained results designated that complexes 1 and 2 exhibited substantial anticancer activity against the cancer cell lines, better than that of L.
Analyst Coverage and Expected Crash Risk: Evidence from Exogenous Changes in Analyst Coverage
Authors: Kim Jeong-Bon , Lu Louise Yi , Yu Yangxin
Published: September 2018

Using brokerage mergers and closures as two sources of exogenous shock to analyst coverage, this study explores the causal effect of analyst coverage on ex ante expected crash risk as captured by the options implied volatility smirk. We find a significant increase in a firm's ex ante expected crash risk subsequent to an exogenous drop in analyst coverage; this positive effect is stronger for firms initially receiving less coverage. Further, we find analysts' ability matters to investors' assessment of future crash risk. Specifically, we find the impact is more pronounced for the coverage terminations of analysts with more firm-specific or general experience, with greater access to resources, or whose prior forecasts are more accurate than those of their peers. Overall, our results suggest that investors in the options market do recognize analysts as important information intermediaries and monitors and, thus, that analyst coverage influences the underlying stock's expected crash risk.

JEL Classifications: G12; M41.
Effects on Comparability and Capital Market Benefits of Voluntary IFRS Adoption
Authors: Barth Mary E. , Landsman Wayne R. , Lang Mark H. , Williams Christopher D.
Published: September 2018

This study addresses whether voluntary IFRS adoption is associated with increased comparability of accounting amounts and capital market benefits. We find that after firms voluntarily adopt IFRS (“adopting” firms), their accounting amounts are more comparable to those of firms that previously adopted IFRS (“adopted” firms) and less comparable to those of firms that apply domestic standards (“non-adopting” firms). Adopting firms exhibit increased liquidity, share turnover, and firm-specific information relative to adopted and non-adopting firms. Neither adopted nor non-adopting firms suffer capital market consequences. Adopting firms with higher comparability with adopted firms have greater capital market benefits after adopting IFRS than adopting firms with lower comparability, and capital market benefits for adopting firms in countries with a relatively high percentage of firms that apply IFRS enjoy greater capital market benefits.
Impact of Visit-to-Visit Fasting Plasma Glucose Variability on the Development of Type 2 Diabetes: A Nationwide Population-Based Cohort Study
Authors: Kim Jung A. , Lee Ji Sung , Chung Hye Soo , Roh Eun , Lee You-Bin , Hong So-hyeon , Kim Nam Hoon , Yoo Hye Jin , Seo Ji A. , Kim Sin Gon , Kim Nan Hee , Baik Sei Hyun , Choi Kyung Mook
Published: September 2018

OBJECTIVE

Although increasing evidence suggests the association between short-term variability of fasting plasma glucose (FPG) and diabetic complications or mortality, the impact of visit-to-visit variability of FPG on the development of type 2 diabetes (T2D) has not been evaluated.

RESEARCH DESIGN AND METHODS

Our analysis included 131,744 Korean men and women without diabetes using the Korean National Health Insurance System cohort with periodic health examination program. FPG variability was calculated using the coefficient of variation (FPG-CV), SD (FPG-SD), and variability independent of the mean (FPG-VIM).

RESULTS

During the median follow-up time of 8.3 years, Kaplan-Meier curves demonstrated lower disease-free probability in the higher FPG variability group compared with the lower FPG variability group. Multivariable Cox proportional hazards analysis exhibited that the hazard ratio for incident T2D was 1.67 (95% CI 1.58–1.77, P < 0.001) in the highest quartile of FPG-CV compared with the lowest quartile of FPG-CV after adjusting for confounding variables, including mean FPG. The association between FPG variability and the risk of T2D was consistent when modeling using FPG-SD and FPG-VIM in both normal and impaired fasting glucose groups. A 1 SD increase in the FPG-CV was associated with a 24% increased risk of T2D in the fully adjusted model.

CONCLUSIONS

Increased variability of FPG is associated with the development of T2D independently of diverse risk factors.
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
Authors: Cousminer Diana L. , Ahlqvist Emma , Mishra Rajashree , Andersen Mette K. , Chesi Alessandra , Hawa Mohammad I. , Davis Asa , Hodge Kenyaita M. , Bradfield Jonathan P. , Zhou Kaixin , Guy Vanessa C. , Åkerlund Mikael , Wod Mette , Fritsche Lars G. , Vestergaard Henrik , Snyder James , Højlund Kurt , Linneberg Allan , Käräjämäki Annemari , Brandslund Ivan , Kim Cecilia E. , Witte Daniel , Sørgjerd Elin Pettersen , Brillon David J. , Pedersen Oluf , Beck-Nielsen Henning , Grarup Niels , Pratley Richard E. , Rickels Michael R. , Vella Adrian , Ovalle Fernando , Melander Olle , Harris Ronald I. , Varvel Stephen , Grill Valdemar E.R. , Hakonarson Hakon , Froguel Philippe , Lonsdale John T. , Mauricio Didac , Schloot Nanette C. , Khunti Kamlesh , Greenbaum Carla J. , Åsvold Bjørn Olav , Yderstræde Knud B. , Pearson Ewan R. , Schwartz Stanley , Voight Benjamin F. , Hansen Torben , Tuomi Tiinamaija , Boehm Bernhard O. , Groop Leif , Leslie R. David , Grant Struan F.A. ,   Bone Mineral Density in Childhood Study, McCormack Shana E. , Mitchell Jonathan A. , Kelly Andrea , Kalkwarf Heidi J. , Lappe Joan M. , Shepherd John A. , Oberfield Sharon E. , Gilsanz Vicente , Zemel Babette S.
Published: September 2018

OBJECTIVE

Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy to gain insight into appropriate classification of this diabetes subtype.

RESEARCH DESIGN AND METHODS

We performed the first genome-wide association study of LADA in case subjects of European ancestry versus population control subjects (n = 2,634 vs. 5,947) and compared against both case subjects with type 1 diabetes (n = 2,454 vs. 968) and type 2 diabetes (n = 2,779 vs. 10,396).

RESULTS

The leading genetic signals were principally shared with type 1 diabetes, although we observed positive genetic correlations genome-wide with both type 1 and type 2 diabetes. Additionally, we observed a novel independent signal at the known type 1 diabetes locus harboring PFKFB3, encoding a regulator of glycolysis and insulin signaling in type 2 diabetes and inflammation and autophagy in autoimmune disease, as well as an attenuation of key type 1–associated HLA haplotype frequencies in LADA, suggesting that these are factors that distinguish childhood-onset type 1 diabetes from adult autoimmune diabetes.

CONCLUSIONS

Our results support the need for further investigations of the genetic factors that distinguish forms of autoimmune diabetes as well as more precise classification strategies.
Prática educomunicativa na formação em motricidade orofacial: relato de experiência
Authors: César Gabriela Ribeiro , Santos Patrícia Conceição , Pena Juliana Araujo , Viana Claudemir Edson , César Carla Patrícia Hernandez Alves Ribeiro
Published: September 2018

Objetivo: relatar um projeto educomunicativo na formação em motricidade orofacial de estudantes de Fonoaudiologia. Método: Participaram dez discentes e uma docente para a elaboração de uma Mostra Fotográfica para retratar a realidade e o cotidiano em Motricidade Orofacial, apresentada em uma Semana Acadêmico-Cultural Universitária. Resultados: Os envolvidos participaram desde o planejamento até a avaliação da Mostra, ampliando o olhar sobre o tema e o uso da fotografia enquanto prática educomunicativa. Conclusão: A possibilidade de o estudante olhar para um objeto/evento, apropriar-se dele transformando o seu significado transcende o “conteúdo” temático acadêmico, pois permite que a reflexão criativa seja a mola propulsora para a mudança de futuros profissionais em Saúde, mais preocupados com a dimensão humana de seu entorno.
Desvantagem vocal em cantores líricos
Authors: Rossi-Barbosa Luiza Augusta Rosa , Souza Joyce Elen Murça de , Barbosa-Medeiros Mirna Rossi
Published: September 2018

Introdução: O Índice de Desvantagem no Canto Clássico (IDCC) auxilia o cantor sobre a percepção da sua voz e o impacto da produção vocal em sua vida profissional. Objetivo: Comparar a autopercepção da desvantagem vocal em cantores líricos e as variáveis sociodemográficas, queixas vocais, uso da voz falada e período dos sinais e sintomas vocais. Métodos: Pesquisa transversal e analítica, com trinta cantores líricos de uma escola pública de canto. Utilizou-se um questionário com dados sociodemográficos, sobre a voz e o IDCC. As variáveis independentes foram dicotomizadas e comparadas com os domínios incapacidade, desvantagem e defeito do IDCC pelo teste Mann-Whitney adotando um nível de significância estatística de 5% (p≤0,05). Resultados: O hábito de pigarrear foi o sintoma mais frequente. Os escores do IDCC apontaram maiores médias no domínio Defeito. Houve diferença estatisticamente significativa em todas as subescalas e no total entre aqueles com e sem cansaço vocal (Incapacidade p=0,003, Desvantagem p=0,028, Defeito p= 0,013, Total p=0,007); bem como quanto ao período de sinais e sintomas vocais entre sem problema/problema agudo e problema crônico (Desvantagem p=0,011, Defeito p=0,008, Total p=0,012); e entre aqueles sem e com queixas vocais (Defeito p=0,022; sendo limítrofe no Total p=0,053). Conclusão: os cantores líricos apresentaram desvantagem vocal dentre os que referem cansaço ao falar e/ou cantar, com queixas vocais e estas em um período considerado crônico.
Treinamento auditivo computadorizado em uma adolescente portadora de neurofibromatose do tipo 2
Authors: Pazini Eduarda , Marques Pâmela Mariel , D’Agostini Ayra Renata , Bertuol Bianca , Kessler Themis Maria , Garcia Michele Vargas , Biaggio Eliara Pinto Vieira
Published: September 2018

A neurofibromatose do tipo 2 é uma doença genética que afeta o Sistema Nervoso Central, principalmente a via auditiva, sendo alguns dos principais sintomas a perda auditiva neurossensorial, o baixo reconhecimento de fala, zumbido e disfunção vestibular. Relata-se neste estudo um processo de intervenção terapêutica por meio do Treinamento Auditivo Computadorizado em uma adolescente com diagnóstico médico de Neurofibromatose tipo 2. Tal intervenção contou com 16 sessões de TA, realizadas com um software específico. Para o estudo realizou-se a avaliação, pré e pós-treinamento, por meio dos resultados da avaliação audiológica básica, Potencial Evocado Auditivo de Tronco Encefálico e avaliação da consciência fonológica, além de analisar os relatos referentes ao processo terapêutico. Os testes comportamentais de processamento auditivo não foram realizados, pois a paciente apresenta acentuada dificuldade de compreensão de fala. Paciente apresentou melhora no reconhecimento de fala e na habilidade de consciência fonológica, apesar do exame eletrofisiológico da audição não demonstrar tais benefícios diretamente na via auditiva em nível de tronco encefálico, para o estímulo clique. Destaca-se o relato da paciente de melhora na compreensão de fala após tal intervenção. Desse modo, observaram-se os efeitos positivos do treinamento auditivo na melhora da percepção auditiva, influenciando positivamente na vida diária da paciente.
Relations between theoretical and real-time accessibility for inter-regional, intra-regional and intra-urban car journeys:The example of Poland
Authors: Wiśniewski Szymon
Published: September 2018

The article presents the results of research devoted to comparing accessibility in terms of theoretical and real travel times by car at inter-regional, intra-regional and intra-urban scales. The research strives to achieve three types of aim. The methodological aim is to assess the suitability of the data for research into transport geography, in particular with regard to accessibility. This objective also focuses on developing a method for acquiring and processing source data from suppliers. The cognitive goal is to analyse the spatial differentiation of theoretical and real travel times at different spatial scales. In terms of application, the focus is on the use of real travel time data for transport planning. Data on theoretical travel times includes the author’s own calculations based on analyses whose key assumption is that cars move on a road network at the maximum speeds allowed by the law with all other variables being excluded. The other source of data (on real travel times) is the Distance Matrix Response provided by Google Maps APIs. Due to methods such as isochrones and cumulative accessibility it was concluded that data obtained from Google servers is highly useful for research into transport geography, including time accessibility analyses. The patterns presented here however cannot be treated uncritically or used for unrestricted analysis. With regard to the cognitive goal, it should be emphasized that spatial variations in travel differences, resulting from theoretical and real variants for journeys between regional cities in Poland, between settlement units within one region, or within one of its large cities, are heterogeneous depending on the nature and length of the journey. Therefore, depending on the spatial extent of analysis, divergences in travel times should be expected.
Pareto Based Virtual Machine Selection with Load Balancing in Cloud Data Centre
Authors: Naik Ketaki Bhalchandra , Gandhi G. Meera , Patil S. H.
Published: September 2018

Cloud Data centers have adopted virtualization techniques for effective and efficient compilation of an application. The requirements of application from the execution perspective are fulfilled by scaling up and down the Virtual Machines (VMs). The appropriate selection of VMs to handle the unpredictable peak workload without load imbalance is a critical challenge for a cloud data center. In this article, we propose Pareto based Greedy-Non dominated Sorting Genetic Algorithm-II (G-NSGA2) for agile selection of a virtual machine. Our strategy generates Pareto optimal solutions for fair distribution of cloud workloads among the set of virtual machines. True Pareto fronts generate approximate optimal trade off solution for multiple conflicting objectives rather than aggregating all objectives to obtain single trade off solution. The objectives of our study are to minimize the response time, operational cost and energy consumption of the virtual machine. The simulation results evaluate that our hybrid NSGA-II outperforms as compared to the standard NSGA-II Multiobjective optimization problem.
A Fault Tolerant Scheduling Heuristics for Distributed Real Time Embedded Systems
Authors: Malika Bachir , Kalla Hamoudi
Published: September 2018

In this paper, fault tolerant task scheduling algorithms are proposed for mapping task graphs to heterogeneous processing nodes. These scheduling heuristics that we propose are redundancy-based software to tolerate hardware faults. We consider only processor permanent failures with a fail-silent behavior. The proposed heuristics generate automatically a real-time fault distributed schedule of dependent and independent tasks into heterogonous multiprocessors architecture. The heuristics are based on active and passive redundancy.
Corporate Social Responsibility (CSR) of Innovative Pharmaceutical Corporations. The Case of BIOGEN
Authors: Witkowska Janina
Published: September 2018

The aim of this paper is to discuss the common features and specificity of Corporate Social Responsibility (CSR) practices of innovative transnational corporations (TNCs) acting in the pharmaceutical industry. The innovativeness of pharmaceutical firms is understood here as their ability to make a breakthrough in the treatment of rare, incurable diseases. The examination of the issue leads to the conclusion that the specificity of CSR in this industry is related to the contradiction between the economic and social/ethical aspects of innovation processes in this field. A key issue of CSR in the innovative pharmaceutical industry seems to be the pricing of drugs, especially orphan and ultra‑orphan drugs, resulting in patients from less developed countries having limited access to life‑saving medicines or those that improve the quality of life. Corporations use their monopolistic position to set extremely high prices. However, without the market/marketing exclusivity offered to pharmaceutical firms by the law, orphan drugs would probably not be developed, produced and commercialized. Traditional CSR practices (corporate philanthropy, community and neighborhood programs, volunteerism etc.) cannot be treated as sufficient ‘compensation’ for the high prices of medicines. Real, true CSR in the innovative pharmaceutical industry requires either abandoning or reducing extreme monopolistic privileges and offering medicines for rare diseases at lower prices.
A Comparative Cross‑Cultural Analysis of the Profile of A Modern Ukrainian Manager: the Imperatives of the Future in the Context of Internationalization
Authors: Glinkowska Beata , Chebotarov Viacheslav A.
Published: September 2018

The preliminary results of the development of the initial theoretical, methodological and applied methodological provisions for the study of the profile of a modern Ukrainian manager are presented in the context of predicting its transformation in the future in the context of deepening internationalization. The results of the Polish‑Ukrainian applied empirical analysis carried out by the authors are discussed. The content of the parameters of a modern Ukrainian manager is disclosed in the framework of the most common models of national business cultures, and directions for the further scientific, practical and methodological development of the problem are determined.
Distribution of the antlion Dendroleon pantherinus (Neuroptera: Myrmeleontidae) in the Czech Republic
Authors: Kuras Tomáš , Mazalová Monika
Published: September 2018

This paper summarizes the records of Dendroleon pantherinus (Fabricius, 1787), a European species of antlion belonging to rare and threatened taxa, in the Czech Republic. The species is associated with an ancient xerothermic broadleave forest habitat. So far, D. pantherinus was recorded only a few times in the Czech Republic − always in the southernmost part of Moravia. Several new records of the species from Moravia and Silesia are given. These are Nivnice, Mohelno, Mašovice (in southeast Moravia) and Bukovec (near the Czech-Polish border, in Silesia), where several specimens were sampled, mostly in the dwellings. Therefore, we presume at least partially synanthropic life history of the species.
A new data to distribution of Epilobium pseudorubescens A.K. Skvortsov (Onagraceae) in Poland
Authors: Terlević Ana , Nobis Marcin
Published: September 2018

Herbarium revision resulted in the finding of five new records of Epilobium pseudorubescens in Poland. The distribution map of the species is provided.
Manx Shearwater (Puffinus puffinus) in Holewa’s list of Silesian birds
Authors: Hudeček Jiří J.
Published: September 2018

The Manx Shearwater (Puffinus puffinus) rarely visitor to middle Europe already in the 19th century. Holewa (1900) introduced a species for Silesia (before 1899), but nothing more in known, not even his source, and his work was criticized at his time. Nevertheless, he rightly assumed the generic membership as well as did all later authors, Mlíkovský’s (2012) evaluation that H. Holewa mentioned an unknown name “Puffinus anglicus” or that he had mistaken it with the name of the Gull-billed Tern
Osculatia – an earlier name for a segregate of Bryum (Bryaceae, Bryophyta)
Authors: Ochyra Ryszard , Plášek Vítězslav , Bednarek-Ochyra Halina
Published: September 2018

Gemmabryum J.R.Spence & H.P.Ramsay is considered to be congeneric with two monotypic South American moss genera, Neobryum R.S.Williams and Osculatia De Not., of which the latter has priority. It is the earliest available generic name for one of the largest segregates of the broadly conceived genus Bryum Hedw. which consists of some 44 species disposed in three sections that have a worldwide distribution. Traditionally, they were all placed in Bryum or Brachymenium Schwägr. and the relevant transfers to Osculatia are effected in the present account.
The Influence of Cigarette Ingredients on Smoking Cessation Rates
Authors: Rodger Matthew , Slater Adam
Published: September 2018

It has been suggested that the common practice of adding ingredients to cigarette tobacco might affect patterns of smoking initiation, consumption or cessation. These suggestions have themselves prompted claims that regulation of such ingredients may contribute to reducing the prevalence of tobacco use and dependence among new and continuing smokers. In order to investigate the evidential basis for such claims, we performed a cross-sectional statistical analysis of smoking quit ratios across a sample of 80 countries, comparing those with high market shares of traditional blended cigarettes and those with high market shares of Virginia-style cigarettes, utilizing the fact that traditional blended cigarettes contain added ingredients whereas Virginia-style cigarettes contain no or very few added ingredients. Our results support the findings of our previous study performed in 2012 (across a sample of 46 countries), showing no evidence that the hypothesised effects exist with regard to quit ratios, and find that the use of ingredients can account for virtually none of the crosscountry variation in quit behaviour. This conclusion is robust to alternative specifications of variables, and to controlling for a variety of socio-economic indicators in a multivariate regression setting. We find socio-economic variables - notably income, education and internet access - exert a significant effect on the quit ratio, inducing higher cessation rates as standards in medical care and information improve as societies develop. We also find various tobacco control measures induce high quit ratios across countries. Both of these findings are in line with existing international evidence on smoking patterns.
A Review of Electronic Cigarette Use Behaviour Studies
Authors: Cahours Xavier , Prasad Krishna
Published: September 2018

E-cigarette use has increased markedly in the past five years; however, current data suggest that conventional smokers switching to e-cigarettes may account for much of the recent increase. How individuals use these products has strong implications for nicotine intake and exposure to other potential toxicants. Studies assessing e-cigarette user behaviours, including puff volume and duration, report wide variations across products, settings, and individuals. Understanding the factors that affect puffing topography will be central to standardising protocols for testing aerosol emissions and regulating e-cigarettes. The amount of aerosol generated can be influenced by a number of factors, including product design, vaping topography, and device setting as highlighted in this review. Further work to understand how the combination of these parameters affects the amount of aerosol generated will be central to defining protocols for testing and regulating e-cigarettes.
Genetic testing for lymphedema in RASopathies
Authors: Paolacci Stefano , Rakhmanov Yeltay , Maltese Paolo Enrico , Bruson Alice , Bertelli Matteo
Published: September 2018

Variants affecting the function of genes in the RAS–mitogen-activated protein kinase (MAPK) signal transduction pathway have been identified as responsible for a group of developmental syndromes known as RASopathies. Noonan (NS) and cardiofaciocutaneous syndromes (CFC) represent the most frequent and best characterized RASopathies. Many cases of RASopathies are associated with lymphatic malformations that finally may result in lymphedema. We developed the test protocol “Lymphedema in RASopathies” on the basis of the latest research findings and diagnostic protocols on lymphatic malformation in RASopathies. The genetic test is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for Emberger syndrome
Authors: Rakhmanov Yeltay , Maltese Paolo Enrico , Paolacci Stefano , Bruson Alice , Bertelli Matteo
Published: September 2018

Emberger Syndrome (ES) is a very rare genetic disorder associated with primary lymphedema, myelodysplasia and immunodeficiency. The syndrome has autosomal dominant inheritance with incomplete penetrance. Sporadic cases caused by de novo germinal mutations in the GATA2 gene have also been described. We developed the test protocol on the basis of the latest research findings and diagnostic protocols on lymphatic malformation in ES. The genetic test is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for hereditary hemorrhagic telangiectasia
Authors: Rakhmanov Yeltay , Maltese Paolo Enrico , Paolacci Stefano , Marinelli Carla , Mattassi Raul Ettore , Amato Bruno , Beccari Tommaso , Dundar Munis , Bertelli Matteo
Published: September 2018

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia characterized by telangiectases and arteriovenous malformations. These lesions cause bleeding, particularly in the nose, gastrointestinal tract and brain. HHT has incomplete penetrance, variable expressivity and genetic heterogeneity. De novo mutations associated with the onset of sporadic HHT have been reported. This Utility Gene Test was prepared on the basis of an analysis of the literature and existing diagnostic protocols. It is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for Marfan syndrome
Authors: Rakhmanov Yeltay , Maltese Paolo Enrico , Marinelli Carla , Castori Marco , Beccari Tommaso , Dundar Munis , Bertelli Matteo
Published: September 2018

Marfan syndrome (MFS) is an inherited connective tissue disorder caused by heterozygous mutations in the FBN 1 gene. Clinical manifestations of MFS include aortic dilatation and dissection, as well as cardiac valvular, ocular, skeletal and neurological manifestations. Prevalence varies from 6 to 20 per 100,000 individuals. Revised Ghent Nosology (2010) is used to establish a clinically based suspected diagnosis to be confirmed by molecular testing. This Utility Gene Test was prepared on the basis of an analysis of the literature and existing diagnostic protocols. Molecular testing is useful for diagnosis confirmation, as well as differential diagnosis, appropriate genetic counselling and access to clinical trials.
Genetic testing for Marfan-like disorders
Authors: Rakhmanov Yeltay , Maltese Paolo Enrico , Paolacci Stefano , Marinelli Carla , Castori Marco , Beccari Tommaso , Dundar Munis , Bertelli Matteo
Published: September 2018

Marfan-like disorders are inherited conditions with features resembling Marfan syndrome but without a pathogenic variant in FBN1, and/or without a clinical diagnosis of Marfan syndrome according to the Revised Ghent criteria, and/or with a pathogenic variant in a different disease gene. Marfan-like disorders are clinically and genetically heterogeneous and have variable prognosis. They may have autosomal dominant or autosomal recessive patterns of inheritance. The prevalence of most Mar-fan-like disorders is unknown. This Utility Gene Test was prepared on the basis of an analysis of the literature and existing diagnostic protocols. Molecular testing is useful for diagnosis confirmation, as well as differential diagnosis, appropriate genetic counselling and access to clinical trials.
Genetic testing for vascular Ehlers-Danlos syndrome and other variants with fragility of the middle arteries
Authors: Rakhmanov Yeltay , Maltese Paolo Enrico , Bruson Alice , Castori Marco , Beccari Tommaso , Dundar Munis , Bertelli Matteo
Published: September 2018

Ehlers-Danlos syndrome (EDS) is an umbrella term for various inherited connective tissue disorders associated with mutations in genes involved in extracellular matrix formation. “The 2017 International Classification of Ehlers-Danlos Syndromes and related disorders” identifies 13 clinical types with mutations in 19 distinct genes. The present module focuses on forms with major vascular involvement: vascular EDS (vEDS) caused by heterozygous mutations in COL3A1, “vascular-like” EDS (vlEDS) caused by recurrent mutations in COL1A1, classical EDS with vascular fragility associated with heterozygous mutations in COL5A1, and kyphoscoliotic EDS associated with recessive variations in PLOD1 and FKBP14. The overall prevalence of EDS is estimated between 1/10,000 and 1/25,000 and vEDS accounts for about 5 to 10% of all EDS cases. This Utility Gene Test was prepared on the basis of an analysis of the literature and existing diagnostic protocols. Molecular testing is useful for diagnosis confirmation, as well as differential diagnosis, appropriate genetic counselling and access to clinical trials.
Genetic testing for tetralogy of Fallot
Authors: Rakhmanov Yeltay , Maltese Paolo Enrico , Marinelli Carla , Beccari Tommaso , Dundar Munis , Bertelli Matteo
Published: September 2018

Tetralogy of Fallot (ToF) combines congenital cardiac defects including ventricular septal defect, pulmonary stenosis, an overriding aorta and right ventricular hypertrophy. Clinical manifestation of this defect depends on the direction and volume of shunting of blood through the ventricular septal defect and the associated right ventricular and pulmonary artery pressures. ToF accounts for 3-5% of congenital heart defects or 0.28 cases every 1000 live births. ToF has autosomal dominant inheritance. This Utility Gene Test was developed on the basis of an analysis of the literature and existing diagnostic protocols. It is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.