bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors in central retinal vein occlusion: A multi-center case-control study conducted on the Italian population
Authors: Trovato Battagliola Edoardo , Pacella Fernanda , Malvasi Mariaelena , Scalinci Sergio Zaccaria , Turchetti Paolo , Pacella Elena , La Torre Giuseppe , Arrico Loredana
Published: December 2021

Purpose

To explore the risk factors for central retinal vein occlusion (CRVO) by comparing a large sample of patients with healthy controls.

Materials and Methods

Multi-center case-control study. The study group includes patients affected by central retinal vein occlusion, confirmed angiographically, aged 50 years old or above (Group A). The control group includes healthy subjects without an history of retinal vein occlusion (Group B). Outcome measures: age, gender, active smoking, presence of uncontrolled arterial hypertension (uHTN), presence of the following comorbidities: diabetes mellitus type II (DMII), chronic liver disease (CLD), chronic kidney disease (CKD), thyroid disease (TD), systemic lupus erythematosus (SLE), hyperhomocystenemia (HHcy), dyslipidemia (DLip), carotid artery disease (CAD), glaucoma, atrial fibrillation (AF), migraine headache (MH), chronic obstructive pulmonary disease (COPD), obstructive sleep apnea syndrome (OSAS), history of myocardial infarction (MI). Odds-ratios were calculated with logistic regression analysis.

Results

A total of 203 patients (Group A) and 339 controls (Group B). Statistically-significant differences were found for the following variables: age (OR: 1.109 [1.081–1.138], p < .001), active smoking (OR: 2.048 [1.210- 3.466], p < .008), DMII (OR: 4.533 [2.097–9.803], p < .001), HHcy (OR: 4.507 [2.477–10.001 ], p < .001), DLip (OR: 2.255 [1.352–3.762], p  =  .002), CAD (OR: 6.632 [2.944- 14.942], p < .001), glaucoma (OR: 4.656 [2.031–10.673], < .001), OSAS (OR: 1.744 [1.023–2.975], < .041), uHTN (OR: 3.656 [2.247–5.949], < .001). No statistically-significant differences were found for the other variables.

Conclusions

Older age, active smoking, as well as presence of DMII, HHcy, DLip, CAD, glaucoma, OSAS, and uHTN, all increase the risk for CRVO. A comprehensive assessment of patients with CRVO is paramount. Adequate control of all the aforementioned risk factors is likely of great significance in reducing the incidence of CRVO among the general population, and it likely plays an important role in improving the prognosis following the occlusive event.
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m

x

same’ su sa ‘Nawalakw (the supernatural spirit wraps around us): impacts of Kwakw

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k

a

’wakw regalia making on identity, wellness and belonging in ‘Y

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lis, British Columbia
Authors: Brown Helen , Isaac Trevor , Timler Kelsey , Newman Elder Vera , Cranmer Andrea , Cranmer Donna
Published: December 2021

In this article, we share findings from a community-based Participatory Action Research project, titled Sanala, which means to be whole in Kwak’wala—the language of the Kwakwaka’wakw (Kwak̓wala-speaking people; a First Nation from what is now called Canada). In response to community priorities, the Sanala team initiated regalia as a weekly programme where people from the ‘Namgis tribe and other surrounding Kwakwaka’wakw Nations on the northwest coast of British Columbia, Canada, come together to create regalia. Participants learn about family crests, design and sew button blankets and dance aprons, and learn oral histories belonging to individuals and families, all within the context of Kwak’wala language revitalization and regalia making. We outline the impacts of this programme on identity, belonging, wholistic health and collective wellbeing, as well as implications for Participatory Action Research and community-led research aimed at strengthening individual and collective health and wellness through Indigenous languages and cultural continuity.
Coccidioidal Meningitis With Hyphal Forms Detected in Cerebrospinal Fluid in a Patient With Ventriculoperitoneal Shunt: A Case Report
Authors: Shi Jeremy , Wong Myra , Xu Ya
Published: December 2021

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis and Coccidioides posadasii. The most severe disseminated coccidioidomycosis results in meningoencephalitis. Literature review reveals very rare reports of hyphal forms of coccidioides organisms detected in CSF. We present a case of a 58-year-old Hispanic male with a 10-year persistence of CM and many ventriculoperitoneal shunt reversions. The patient initially presented with a hydrocephalus of unknown source. The diagnosis of CM was made three years later based on a culture. On this presentation at the emergency department (ED), the patient reported one day of worsening left-sided weakness, altered mental status, and vomiting. We detected the hyphal forms of coccidioides in the cerebrospinal fluid (CSF) during cytopathology examination. Awareness of this reversion from spherule form to hyphal form is helpful in diagnosis and treatment. The hyphal forms of coccidioides may be associated with the increased risk of obstruction of the shunts. It is important to submit CSF for cytopathology examination for diagnosis, especially in patients with shunts.
Humoral immune response and lymphocyte levels after complete vaccination against COVID-19 in a cohort of multiple sclerosis patients treated with cladribine tablets
Authors: Grothe Christoph , Steffen Falk , Bittner Stefan
Published: December 2021

Background

Patients with multiple sclerosis (MS) receiving immunomodulatory drugs were excluded from clinical trials on COVID-19 vaccines. Therefore, data regarding the efficacy of COVID-19 vaccines to induce humoral immunity in MS patients treated with B- and T-cell depleting agents is urgently warranted. Cladribine tablets are a high-efficacy disease-modifying treatment that exerts its therapeutic effect via sustained but transient lymphocyte depletion.

Aim

We report humoral responses in a German cohort of MS patients treated with cladribine tablets.

Methods

This retrospective analysis included patients ≥18 years who were treated with cladribine tablets for relapsing MS in the first or second year and were fully vaccinated against COVID-19. Two weeks after the second vaccination at the earliest, blood samples were obtained for the assessment of anti-SARS-CoV-2 IgG antibodies, lymphocyte counts, B-cells, CD4+ T-cells, and CD8+ T-cells. Anti-SARS-CoV-2 IgG antibodies were quantified with the LIAISON® SARS-CoV-2 TrimericS IgG assay. Positivity was defined at a cutoff value of 33.8 BAU/mL.

Results

In total, 38 patients (73.7% female, aged 23–66 years) were included in the analysis. Ten patients (26.3%) were treatment-naïve before initiating treatment with cladribine tablets. Most patients (84.2%) received mRNA vaccines. The time between the last dose of cladribine tablets and vaccination ranged between 2 and 96 weeks. Six patients (15.8%) were vaccinated within 4 weeks of their last cladribine dose. All patients achieved positive anti-SARS-CoV-2 IgG antibody levels. Humoral immune response was independent of age, time of vaccination in relation to the last cladribine dose, lymphocyte counts as well as B- and T-cell counts.

Conclusions

Treatment with cladribine tablets did not impair humoral response to COVID-19 vaccination. Time since last cladribine dose, age, prior therapy, lymphocyte count as well as B- and T-cell counts had no effect on seropositivity of anti-SARS-CoV-2 IgG antibodies.
Pulsed plasma nitriding of high velocity oxy-fuel sprayed Inconel 625 coatings
Authors: Mindivan Harun
Published: December 2021

A hardening of high velocity oxy-fuel sprayed Inconel 625 coating systems was performed by pulsed plasma nitriding treatment. After deposition of an Inconel 625 coating, samples were pulsed plasma nitrided at 520 °C for 12 h in a gas ratio of 3:1 N2 and H2 under a constant pressure of 2.5 × 102 Pa. Pulsed plasma nitriding improved the microhardness of the high velocity oxy-fuel sprayed Inconel 625 coating from 355 to 401 HV0.05. The high velocity oxy-fuel-sprayed Inconel 625 coating after pulsed plasma nitriding process showed excellent corrosion resistance as well as a reduction of both the friction coefficient and wear rate during the sliding phase in a 3.5 wt.% NaCl solution against sliding action of Al2O3 ball.
Impact of comorbid post traumatic stress disorder on multiple sclerosis in military veterans: A population-based cohort study
Authors: Leekoff Mark , Culpepper William , Jin Shan , Lee-Wilk Terry , Wallin Mitchell
Published: December 2021

Background:

Very little is known regarding the impact of post traumatic stress disorder (PTSD) on the course of multiple sclerosis (MS).

Objectives:

To explore the impact of pre-existing PTSD on MS relapses, magnetic resonance imaging (MRI) activity, and disability in a large population-based cohort.

Methods:

Military Veterans with MS and PTSD prior to symptom onset (MSPTSD, n = 96) were identified using the Department of Veterans Affairs MS databases. MSPTSD cases were matched to MS controls without PTSD ( n = 95). Number of relapses, number of new T2 lesions and new gadolinium lesions on brain MRI, and neurological disability were abstracted between 2015 and 2019.

Results:

The mean annualized relapse rate was greater in the MSPTSD group versus controls (0.23 vs 0.06, respectively; p < 0.05), as was the annualized mean number of new T2 and gadolinium-enhancing lesions on brain MRI (0.52 vs 0.16 and 0.29 vs 0.08, respectively; p < 0.05). Disability accrual (time to Disability Status Scale 6.0) was more rapid (23.7 vs 29.5 years, p < 0.05) in relapsing MS patients with PTSD.

Conclusion:

Patients with MSPTSD have higher disease activity and reach disability endpoints more rapidly than controls. This is the first study to show PTSD as a potentially modifiable risk factor for MS relapses, MRI activity, and disability.
Wear characteristics of additively manufactured AlSi10Mg against EN-31 and silicon carbide abrasive sheet counter bodies using box Behnken design approach
Authors: Radhakrishnan Raj Mohan , Ramamoorthi Venkatraman , Srinivasan Raghuraman
Published: December 2021

High strength-to-weight ratio materials are used in the automotive and aerospace industries, and AlSi10Mg is suitable for those applications. The research aims to compare and investigate the wear characteristics of selective laser melted AlSi10Mg pin against two counter bodies, EN-31 hardened steel, and silicon carbide abrasive sheet. The wear rate of additively manufactured AlSi10Mg pin at 0° building orientation was investigated using the box Behnken design approach to identify the suitable wear parameters with the pin on the disc testing facility. Based on analysis of variance, the interaction of load with sliding distance significantly influenced the wear rate of AlSi10Mg in both counter body cases. The adhesion and abrasion wear mechanism were observed in AlSi10Mg with EN-31 and silicon carbide abrasive sheet, respectively. The findings reveal the effect of two counter bodies on the SLMed AlSi10Mg wear phenomenon. Finally, severe wear was observed in the AlSi10Mg pin against the silicon carbide counter body.
You can tell it works – Experiences from using the VIPS practice model in primary healthcare
Authors: Mjørud Marit , Røsvik Janne
Published: December 2021

Introduction

Person-centred care is a philosophy rather than a method ready for implementation and utilization in daily clinical work. Internationally, few methods for person-centred care have been widely adopted in clinical dementia care practice. In Norway, the VIPS practice model is one that is commonly used for the implementation and use of person-centred care in primary healthcare.

Method

Nursing home physicians, managers and leaders in the municipalities, care institutions and domestic nursing care services were eligible for inclusion if their workplace had implemented and used the VIPS practice model for a minimum of 12 months. Individual interviews were conducted via Facetime, Skype or telephone and analysed with qualitative content analysis.

Findings

In all, 20 respondents were included: one manager of health and care services in the municipality, six managers and leaders working in domestic care or daytime activity centres and 10 managers/leaders and three physicians working in nursing homes. Two global categories emerged: category 1: Change in staff’s professional reasoning with two sub-categories: (a) an enhanced professional level in discussions and (b) a change in focus from task to person; and category 2: Changes in the clinical work, with three sub-categories: (a) effective interventions, (b) a person-centred work environment and (c) changes in cooperation between stakeholders.

Conclusion

Regular use of the VIPS practice model appeared to change the work culture for the benefit of both service users and frontline staff. Increased cooperation between frontline staff, nurses, physicians and next of kin was described. Staff were more focused on the needs of the service users, which resulted in care interventions tailored to the needs of the individual with dementia, loyalty to care plans and fewer complaints from next of kin.
Rawls’ traces in contemporary philosophy of education
Authors: Costa M. Victoria
Published: December 2021

This article examines the many traces of John Rawls’ theory of justice in contemporary philosophy of education. Beyond work that directly explores the educational implications of justice as fairness and political liberalism, there are many interesting debates in philosophy of education that make use of Rawlsian concepts to defend views that go well beyond those advocated in justice as fairness. There have also been methodological debates on Rawls’ distinction between ideal and non-ideal theory which concern the proper balance between empirically informed discussion and fruitful normative reflection.
Using social domain theory to seek critical consciousness with young children
Authors: Ilten-Gee Robyn , Manchanda Sarah
Published: December 2021

The question of ‘developmental appropriateness’ in education can be both empowering and inhibiting. When are students ‘ready’ to talk about social injustices and systemic inequalities? How might educators introduce social inequities using developmental findings about reasoning? This article presents social domain theory as a lens through which educators can approach critical consciousness education with young children. An overview of Freire’s critical consciousness construct is presented, including educational interventions, methods, and approaches that support critical consciousness. An overview of social domain theory is also presented. Social domain theory is a developmental theory of sociomoral reasoning that describes three domains of social knowledge that develop independently, and get applied/coordinated/prioritized differently in context by individuals. This theory, and the research stemming from it, has shown that there are developmental transition points during which children come to view their previous logic as inadequate, and are likely to shift their understandings of moral, conventional, and personal issues. A parallel is drawn between these transition points and the process of wrestling with and overturning ‘contradictions’ in critical consciousness education. Contradictions are theorized as dehumanizing power dynamics that show up in students’ everyday circumstances. This article provides tables outlining example contradictions for young children, key domain–related reasoning shifts for young children, and examples for how to create lesson plans that take these two factors into account. Finally, we propose a method of facilitating self-assessment of critical consciousness with young children. Self-reflection questions are provided for teachers and students.
Efficacy of High-Pressure Balloon for the Treatment of Arteriovenous Fistula Stenosis: A Meta-Analysis
Authors: Li Yu , Cui Wenhao , Wang Jukun , Zhang Chao , Luo Tao
Published: December 2021

Objective:

The objective of the present study was to compare the effectiveness of high-pressure balloon (HPB) versus conventional balloon (CB) angioplasty in treating arteriovenous fistula (AVF) stenosis.

Materials and Methods:

A meta-analysis was conducted using data acquired from PubMed, EMBASE, the Cochrane Library, SinoMed, CNKI, WanFang, and VIP databases from the time the databases were established to December 2020. All analyses included in the studies comprised the subgroups of HPB and CB. The patency rates of AVF were compared between 2 groups at 3, 6, and 12 months after operation.

Results:

Seven studies comprising 364 patients were included in the meta-analyses. The pooled results revealed that restenosis rate of AVFs treated with HPB was significantly lower than that of AVFs treated with CB at 3 months (odds ratio [OR] = 0.32, 95% confidence interval [CI] = 0.16 to 0.61, p<0.001) and 6 months after operation (OR= 0.29, 95% CI = 0.11 to 0.79, p = 0.01). In addition, the technical success rate of HPB groups was higher (OR = 0.13, 95% CI = 0.05 to 0.36, p<0.001). However, no significant difference was observed between HPB and CB groups at 12 months after operation (OR = 0.68, 95% CI = 0.30 to 1.52, p = 0.35). No significant publication bias was observed in the analyses.

Conclusion:

High-pressure balloon is a potential option for the treatment of AVF stenosis, with a lower 3- and 6-month restenosis rate than CB. However, 12-month patency rate of HPB was not superior to CB. Therefore, further studies should be conducted to investigate the mechanisms of restenosis after angioplasty.
Incidence and Predictors of Access Site Vascular Complications Following Ultrasound-Guided MANTA Closure Deployment
Authors: Miyashita Hirokazu , Moriyama Noriaki , Laine Mika
Published: December 2021

Purpose:

There is no report on the reproducibility of the ultrasound-navigated MANTA deployment (US-MANTA) technique and little is known about predictors for US-MANTA-related vascular complication (VC). This study aimed to assess the incidence and predictors of access-site VC using the US-MANTA technique and report insights of MANTA-related VC from consecutive cases following large-bore arteriotomy.

Materials and Methods:

Consecutive patients who underwent transfemoral transcatheter aortic valve replacement with the US-MANTA technique from November 2018 to February 2020 were evaluated. MANTA-related VC was defined as access-site complications leading to major or minor VCs based on Valve Academic Research Consortium-2 criteria.

Results:

Among 378 patients, 23 cases (6.1%) of MANTA-related VC (major VC: n=7 [1.9%], minor VC: n=16 [4.2%]) were identified. No significant difference was observed in the incidence of MANTA-related VC over the observational period (first quartile: 5.3%, second: 5.4%, third: 7.4%, and fourth: 6.3%, p>.50). In 7 patients with MANTA-related major VC, 4 (57.1%) of complications resulted from incomplete apposition of the toggle due to anterior wall calcification of the common femoral artery (CFA). Anterior calcification of the CFA determined by computed tomography was identified as an independent predictor of MANTA-related VCs.

Conclusions:

The US-MANTA technique sustainably provides a low rate of access-site VCs following large-bore arteriotomy. Incomplete apposition of the toggle due to anterior calcification of the CFA may lead to ongoing vascular and bleeding complications.
Do Redistricting Commissions Avoid Partisan Gerrymanders?
Authors: Best Robin E. , Lem Steve B. , Magleby Daniel B. , McDonald Michael D.
Published: December 2021

As attempts to combat partisan gerrymandering transition from proposals to the Supreme Court to state-based districting commissions, it is time to ask two questions. First, how well did commissions in the 2010 round of redistricting perform as neutral decision makers? We answer that question with applications to each of the three independent commissions (AZ, CA, and WA) and four other commission forms (IA, NJ, NY, and VA) in place for post-2010. We take as the neutrality criterion the idea that a commission would produce a district plan that comports with a partisan outcome that could be expected from a set of approximately 10,000 computer generated plans adhering to minimalist constraints of contiguity, compactness, and equal populations. Our results indicate three of seven commissions produced suspect results that redounded to the benefit of one party or the other: pro- Democrat in Arizona; pro-Republican in New Jersey and Virginia.
Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques
Authors: Xin Xin , Li Jie , Zhao Yanqun , Wang Pei , Tang Bin , Yao Xinghong , Liao Xiongfei , Ma Jiabao , Orlandini Lucia Clara
Published: December 2021

Objectives: In breast radiotherapy, the proximity of the target to sensitive structures together with the uncertainty introduced by respiratory movement, make this treatment one of the most studied to increase its effectiveness. Dosimetric and physical variables play an important role and the study of their correlation and impact on treatment is fundamental. This retrospective study aims to highlight the dosimetric differences of 2 different clinical data sets of patients receiving left-sided breast irradiation in free breathing (FB) or breath hold (BH). Methods: A total of 155 left breast carcinoma patients receiving whole-breast irradiation in FB (73 patients) and BH (82 patients) were enrolled in this study. The dosimetric parameters of the target, heart, left and right lung and right breast were evaluated and compared, and possible correlations were studied in both groups. Results: No significant difference ( P > .05) was found in the target dosimetry; a clear advantage in BH for both high and low doses received by the heart, with reductions of the dosimetric parameters between 27.1% and 100% ( P < .003); for the left lung reductions decreased with increasing dose (−22.4% and −13.4% for doses of 5 and 20 Gy, respectively, P < .003). Conclusion: Significant correlations for BH treatments were registered between the volumes of the target and left lung, and the dosimetric parameters of the heart and left lung. BH treatment brings significant dosimetric advantages to organs at risk for a wide range of patients with different anatomy, target volumes and lung capacity, with additional benefits for small-sized breasts and important lung capacity.
Indications and outcomes of glenoid osteotomy for posterior shoulder instability: a systematic review
Authors: Sardar Huda , Lee Sandra , Horner Nolan S , AlMana Latifah , Lapner Peter , Alolabi Bashar , Khan Moin
Published: December 2021

Background

There is limited evidence examining glenoid osteotomy as a treatment for posterior shoulder instability.

Methods

A search of Medline, Embase, PubMed and Cochrane Central Register of Controlled Trials was conducted from the date of origin to 28th November 2019. Nine out of 3,408 retrieved studies met the inclusion criteria and quality was assessed using the Methodological Index for Non-randomized Studies tool.

Results

In 356 shoulders, the main indication for osteotomy was excessive glenoid retroversion (greater than or equal to approximately −10°). The mean preoperative glenoid version was −15° (range, −35° to −5°). Post-operatively, the mean glenoid version was −6° (range, −28° to 13°) and an average correction of 10° (range, −1° to 30°) was observed. Range of motion increased significantly in most studies and all standardized outcome scores (Rowe, Constant–Murley, Oxford instability, Japan Shoulder Society Shoulder Instability Scoring and mean shoulder value) improved significantly with high rates of patient satisfaction (85%). A high complication rate (34%, n = 120) was reported post-surgery, with frequent cases of persistent instability (20%, n = 68) and fractures (e.g., glenoid neck and acromion) (4%, n = 12). However, the revision rate was low (0.6%, n = 2).

Conclusion

Glenoid osteotomy is an appropriate treatment for posterior shoulder instability secondary to excessive glenoid retroversion. However, the high rate of persistent instability should be considered when making treatment decisions. Level of Evidence: Systematic review; Level 4
Traditional Interference Experiments vs. Method Comparison Interference Experiments
Authors: Krouwer Jan S.
Published: December 2021

Two papers have appeared evaluating interferences in glucose meters. These studies are method comparisons with the added information of the medication(s) taken by the subjects. This paper contrasts a traditional interference study with the method comparison protocols. Unlike the advice in CLSI EP7, a substance that interferes should be reported even if the level of interference is clinically acceptable. The evidence of no clinically important interference in the method comparison protocol is very weak, and there is no possibility to detect statistically significant interferences. I provide an example where vitamin C at a therapeutic level was within clinical error limits, but when the concentration was at levels used to treat cancer, there was bias well above clinically acceptable limits.
On HIV assemblages, inequalities and subject formation
Authors: Brown Gavin , Di Feliciantonio Cesare
Published: December 2021

Drawing on our situated experience as geographers of sexualities living and working in the Minority World, this response addresses some of the concerns raised by our interlocutors around the use of assemblage thinking, socio-spatial inequalities and subject formation.
Christian early childhood leaders: Management challenges and responses
Authors: Shields Marion , Hattingh Sherene
Published: December 2021

This study investigated the management challenges that Christian early childhood leaders, from four different Christian denominations, encountered in their responsibilities, and in particular, the approaches they used in resolving them. A research design of grounded theory using data collected from survey questionnaires, semi-structured interviews, and document analysis enabled themes to emerge. A Christian worldview underpinned and framed the leaders’ thoughts, actions, communication, and relationships with students, staff, parents, and the community. For these leaders, their close, reciprocal connection with God sustained, guided and even at times impelled their approach to their daily practice and especially in managing challenges.
Exploring the Optimal Allocation Decision-Making of Expenditure Budget in Hospitals Under Multi-Objective Constraints: Evidence from Urban Public Hospitals, China
Authors: Ren Weicun , Zhao Yizhen , Zhong Huiliang , Fu Xiaoli , Wu Jian
Published: December 2021

Hospitals in many countries face the need for balancing different categories of expenditures to achieve multiple goals within a limited budget. This study established a two-stage fuzzy linear programming (FLP) estimation model to explore the optimal allocation decision-making of expenditure budget under the multi-objective constraints. Taking all urban public hospitals in Henan province of China as a sample, the optimal allocation decision-making of total expenditure budget was tested with the human resources expenditures (HE) as the dependent variable. And the outcome was compared with the actual expenditure data of these hospitals between 2010 and 2016. The study found that when the HE achieves the maximum and minimum feasible scale, the expenditure scales of the budget allocation categories including pharmaceutical expenditures, medical supplies expenditures, and other expenditures were all within a reasonable range. Among them, the observed promoting space for HE was 3.78 billion yuan. The results show that the FLP method can help urban public hospitals to make better total expenditure budget allocation decisions, which can maintain their reasonable expenditure structure under the hospitals’ development goals and the government’s regulatory requirements.
Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
Authors: Lai Carlo , Ciacchella Chiara , Pellicano Gaia Romana , Altavilla Daniela , Sambucini Daniela , Paolucci Teresa , Sorgi Maria Laura , Di Franco Manuela , Saggini Raoul , Aceto Paola
Published: December 2021

Background

Fibromyalgia is a chronic pain syndrome which occurs in the absence of an organic damage, whom causes is still unclear. Aims of this pilot study were to investigate the neural correlates of fibromyalgia in response to pain-related visual stimuli and explore the psychological differences among fibromyalgia, chronic low back pain (CLBP) and healthy conditions.

Methods

After a clinical assessment, electrophysiological responses to pain-related visual stimuli were recorded using a 256-Hydrocel Geodesic-Sensor-Net. Event-related potentials (ERPs), standardised low-resolution electromagnetic tomography (sLORETA), and psychological (Symptom Checklist-90-Revised) data were analysed for a total sample of 23 women (5 healthy volunteers, 12 fibromyalgia patients, 6 CLBP patients).

Results

The main finding was that fibromyalgia women reported a different brain response to pain-related visual stimuli on the frontal montage compared to women with CLBP ( p = .028). Moreover, fibromyalgia women showed an increased activity mainly on the hippocampus ( p = .003) and the posterior cingulate cortex ( p ≤ .001) in response to algic stimuli compared to not algic ones. Lastly, these women presented higher scores on the somatization ( p = .002), obsession-compulsion ( p = .045), depression ( p = .043) and positive symptom distress ( p = .023) dimensions compared to the healthy women.

Conclusions

These preliminary results suggest that although the painful symptoms are similar, the central elaboration of pain could be different between women with fibromyalgia and those with CLBP. Moreover, these findings provide preliminary evidences about the great alert and the central sensitivity to pain-related information regarding fibromyalgia patients.
Location effects on bend-twist coupling modes characteristic of the laminate plates
Authors: Ying Zhang , Liqiang An , Zhangqi Wang
Published: December 2021

In this paper, the effects of coupling location on the properties of bending-twist modes are proposed. The static test and modal analysis of the composite plates are investigated. Initial coupling effects are first obtained from the static test of the plates. The frequencies, nodal lines, and the mode shapes are then studied experimentally and numerically. A new method is proposed to quantitatively describe the bending-twist coupling performance of laminates using modal assurance criterion. The results show that the coupling location in the middle coupled plates show good coupling effects at lower order vibrations. These results also show that the effect of coupling stiffness. The conclusions can be considered as a reference to analyze the coupling phenomenon of large composite wind turbine blades.
Neutrophil-to-lymphocyte ratio, blood eosinophils and COPD exacerbations: a cohort study
Authors: Ellingsen Jens , Janson Christer , Bröms Kristina , Lisspers Karin , Ställberg Björn , Högman Marieann , Malinovschi Andrei
Published: December 2021

Background

Blood neutrophil-to-lymphocyte ratio (NLR) and blood eosinophils (B-Eos) are emerging biomarkers in COPD. This study examined whether they could predict acute exacerbations of COPD (AECOPDs), and determined their longitudinal stability.

Methods

In this closed cohort study, Swedish subjects with spirometry-verified COPD attended three yearly visits in a stable phase of the disease. Blood cell counts, spirometry and questionnaire-assessed AECOPD-history (worsening of COPD leading to an unscheduled visit and/or use of antibiotics and/or oral corticosteroids) were collected at each visit.

Results

Of 466 included subjects 57% were female. Baseline mean±sdforced expiratory volume in 1 s was 58±17% predicted. High NLR (≥3.0) was more common in subjects with previous AECOPDs than in those without (33.5%versus20.4%, p=0.002). In two-level mixed-effects logistic regression models adjusted for confounders, NLR as a continuous variable (OR 1.20, 95% CI 1.04–1.38) and B-Eos ≥300 cells·µL−1(OR 1.54, 95% CI 1.06–2.24) were associated with future AECOPDs. In 386 subjects with blood cell data available at all three visits, the intraclass correlation coefficient for NLR was 0.61 (95% CI 0.56–0.66) and for B-Eos 0.69 (95% CI 0.64–0.73). NLR was persistently ≥3.0 in 10.6% and B-Eos was persistently ≥300 cells·µL−1in 15.3%.

Conclusions

Stable phase NLR and B-Eos were associated with future AECOPDs. NLR on its own is probably not useful to predict AECOPDs but might be included in a risk scoring index. A minority of subjects with COPD had persistently elevated stable-phase NLR or B-Eos, and the biomarkers showed fair longitudinal reliability.
Identification of proteins associated with bast fiber growth of ramie by differential proteomic analysis
Authors: Li Fu , Zeng Zheng , Huang Renyan , Wang Yanzhou , Liu Touming
Published: December 2021

Background

Ramie is an important fiber-producing crop in China, and its fibers are widely used as textile materials. Fibers contain specialized secondary cellular walls that are mainly composed of cellulose, hemicelluloses, and lignin. Understanding the mechanism underlying the secondary wall biosynthesis of fibers will benefit the improvement of fiber yield and quality in ramie.

Results

Here, we performed a proteomic analysis of the bark from the top and middle parts of the stem, where fiber growth is at different stages. We identified 6971 non-redundant proteins from bast bark. Proteomic comparison revealed 983 proteins with differential expression between the two bark types. Of these 983 proteins, 46 were identified as the homolog of known secondary wall biosynthetic proteins of Arabidopsis, indicating that they were potentially associated with fiber growth. Then, we proposed a molecular model for the secondary wall biosynthesis of ramie fiber. Furthermore, interaction analysis of 46 candidate proteins revealed two interacting networks that consisted of eight cellulose biosynthetic enzymes and seven lignin biosynthetic proteins, respectively.

Conclusion

This study sheds light on the proteomic basis underlying bast fiber growth in ramie, and the identification of many candidates associated with fiber growth provides important basis for understanding the fiber growth in this crop.
Immune response to hepatitis B vaccine following complete immunization of children attending two regional hospitals in the Southwest region of Cameroon: a cross sectional study
Authors: Anutebeh Ephesians N. , Tatah Lambed , Feteh Vitalis F. , Aroke Desmond , Assob Jules C. N. , Choukem Simeon Pierre
Published: December 2021

Background

Hepatitis B virus (HBV) infection despite being a vaccine preventable disease remains a global public health problem. In Cameroon, the hepatitis B vaccine was introduced in the expanded program on immunisation in 2005, but there has been limited evaluation of the HBV surface antibody response post vaccination.

Objective

We investigated the immune response to hepatitis B vaccine in infants who received the DPT-Hep B-Hib vaccine, and we assessed HBsAg carriage in non-responders. We also investigated factors associated with non-response or poor response.

Methods

Using a hospital based cross sectional design and a structured questionnaire over a four-month period (January to April 2019), we collected data to determine factors associated with hepatitis B surface antibody (anti-HBs) response from infants aged 6 to 9 months attending infant welfare clinics (IWC) at the Buea and Limbe regional hospitals. We collected venous blood and measured anti-HBs titres using a quantitative Foresight® ELISA. We entered and analysed data using EpiData version 3.1 and SPSS version 25 respectively.

Results

Of the 161 infants enrolled, 159 (98.8%) developed anti-HBs antibodies. Of these 159, 157 (97.5%) and 117 (72.7%) developed ≥ 10.0 mIU/ml (seroprotection) and ≥ 100.0 mIU/ml anti-HBs titres respectively. Being younger (6 months old) was associated with seroprotection (Cramer V = 0.322, p = 0.001). Spearman rho’s relational analysis showed that immunity against HBV reduced as the duration since the last dose increased (r = −0.172; P = 0.029). However, a Firth logistic regression showed no significant association of factors with inadequate immunity. All 12 (7.5%) infants exposed to HBV at birth, received the hepatitis B vaccine at birth, including four who received HBIG, and all were protected. Four infants (2.5%) had anti-HBs titres < 10.0 mIU/mL (non-responders) but had no peculiarity.

Conclusion

The seroprotective rate following hepatitis B vaccination of infants is high even in exposed infants. Our study suggests that Cameroon’s HBV vaccine in the Expanded Program on Immunisation (EPI) is effective against HBV, although we could not account for the 2.5% non-response rate. Large scale studies are needed to further explore non-response to the vaccine.
A survey of nursing teachers’ awareness of discrimination and inequity in telephone nursing care
Authors: Holmström Inger K , Kaminsky Elenor , Höglund Anna T , Carlsson Marianne
Published: December 2021

Background

Nursing care should be respectful of and unrestricted by patients’ age, ethnicity, gender, dis/abilities or social status, and such values should be taught to nursing students. Nursing teachers are crucial as role models, and their values are essential. In telephone nursing, only age, sex and ethnicity are known to the registered nurses, which can be challenging. The aim of this study was to explore awareness of discrimination and inequity in telephone nursing among nursing teachers.

Methods

A study specific survey was filled in by 135 nursing teachers from three universities in Sweden. The survey included short descriptions of 12 fictive persons who differed in age, ethnicity and sex and with questions about their estimated life situation. The teachers’ estimations of life situation were ranked from lowest probability to highest probability. A ‘good life index’ was constructed and calculated for each fictive person. It included quality of life, power over one’s own life and experience of discrimination.

Results

The results indicate that the nursing teachers were aware of how power and age, ethnicity and sex are related; that is, they were aware of discrimination and inequity in healthcare. The persons assessed to be most likely to lead a good life were males of Swedish origin, followed by females of Swedish origin. Persons with non-European origin were estimated to have the highest probability of experiencing discrimination.

Conclusions

The nursing teachers were aware of discrimination and inequity in healthcare. They were able to estimate a fictive person’s life situation based on the limited knowledge of age, ethnicity and sex. This is important, as their values are pivotal in theoretical and practical nursing education.
Antibiotic resistance modifying ability of phytoextracts in anthrax biological agent Bacillus anthracis and emerging superbugs: a review of synergistic mechanisms
Authors: Dassanayake Mackingsley Kushan , Khoo Teng-Jin , An Jia
Published: December 2021

Background and objectives

The chemotherapeutic management of infections has become challenging due to the global emergence of antibiotic resistant pathogenic bacteria. The recent expansion of studies on plant-derived natural products has lead to the discovery of a plethora of phytochemicals with the potential to combat bacterial drug resistance via various mechanisms of action. This review paper summarizes the primary antibiotic resistance mechanisms of bacteria and also discusses the antibiotic-potentiating ability of phytoextracts and various classes of isolated phytochemicals in reversing antibiotic resistance in anthrax agentBacillus anthracisand emerging superbug bacteria.

Methods

Growth inhibitory indices and fractional inhibitory concentration index were applied to evaluate the in vitro synergistic activity of phytoextract-antibiotic combinations in general.

Findings

A number of studies have indicated that plant-derived natural compounds are capable of significantly reducing the minimum inhibitory concentration of standard antibiotics by altering drug-resistance mechanisms ofB. anthracisand other superbug infection causing bacteria. Phytochemical compounds allicin, oleanolic acid, epigallocatechin gallate and curcumin andJatropha curcasextracts were exceptional synergistic potentiators of various standard antibiotics.

Conclusion

Considering these facts, phytochemicals represents a valuable and novel source of bioactive compounds with potent antibiotic synergism to modulate bacterial drug-resistance.
Epidemiology and demographics of juvenile idiopathic arthritis in Africa and Middle East
Authors: Al-Mayouf Sulaiman M. , Al Mutairi Muna , Bouayed Kenza , Habjoka Sara , Hadef Djohra , Lotfy Hala M. , Scott Cristiaan , Sharif Elsadeg M. , Tahoun Nouran
Published: December 2021

Juvenile Idiopathic Arthritis (JIA) is a group of chronic heterogenous disorders that manifests as joint inflammation in patients aged <16 years. Globally, approximately 3 million children and young adults are suffering from JIA with prevalence rates consistently higher in girls. The region of Africa and Middle East constitute a diverse group of ethnicities, socioeconomic conditions, and climates which influence the prevalence of JIA. There are only a few studies published on epidemiology of JIA in the region. There is an evident paucity of adequate and latest data from the region. This review summarizes the available data on the prevalence of JIA and its subtypes in Africa and Middle East and discusses unmet needs for patients in this region. A total of 8 journal publications were identified concerning epidemiology and 42 articles describing JIA subtypes from Africa and Middle East were included. The prevalence of JIA in Africa and Middle East was observed to be towards the lower range of the global estimate. We observed that the most prevalent subtype in the region was oligoarticular arthritis. The incidence of uveitis and anti-nuclear antibody (ANA) positivity were found to be lower as compared to the incidence from other regions. There is a huge unmet medical need in the region for reliable epidemiological data, disease awareness, having regional and local treatment guidelines and timely diagnosis. Paucity of the pediatric rheumatologists and economic disparities also contribute to the challenges regarding the management of JIA.
Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro
Authors: Qin Gaofeng , Dong Yunfang , Liu Zhenhong , Gong Zhuoyan , Gao Chenyan , Zheng Mingcui , Tian Meijing , He Yannan , Zhong Liqun , Wang Pengwen
Published: December 2021

Background

Shen-Zhi-Ling oral liquid (SZL) is an herbal formula known for its efficacy of nourishing “heart and spleen”, and is used for the treatment and prevention of middle- and early-stage dementia. This study investigated the effects of SZL on amelioration of AD, and examined whether the underlying mechanisms from the perspective of neuroprotection are related to brain glucose metabolism.

Methods

Firstly, LC–MS/MS was used to analysis the SZL mainly enters the blood component. Then, the effects of SZL on cognitive and behavioral ability of APP/PS1 double transgenic mice and amyloid protein characteristic pathological changes were investigated by behavioral study and morphological observation. The effects of SZL on the ultrastructure of mitochondria, astrocytes, and micrangium related to cerebral glucose metabolism were observed using transmission electron microscopy. Then, micro-PET was also used to observe the effects of SZL on glucose uptake. Furthermore, the effects of SZL on insulin signaling pathway InR/PI3K/Akt and glucose transporters (GLUT1 and GLUT3) were observed by immunohistochemistry, Western-blot and RT-qPCR. Finally, the effects of SZL on brain glucose metabolism and key enzyme were observed. In vitro, the use of PI3K and/or GSK3β inhibitor to observe the effects of SZL drug-containing serum on GLUT1 and GLUT3.

Results

In vivo, SZL could significantly ameliorate cognitive deficits, retarded the pathological damage, including neuronal degeneration, Aβ peptide aggregation, and ultrastructural damage of hippocampal neurons, improve the glucose uptake, transporters and glucolysis. Beyond that, SZL regulates the insulin signal transduction pathway the insulin signal transduction pathway InR/PI3K/Akt. Furthermore, 15% SZL drug-containing serum increased Aβ42-induced insulin signal transduction-pathway related indicators and GLUT1 and GLUT3 expression in SH-SY5Y cells. The improvement of GLUT1 and GLUT3 in the downstream PI3K/Akt/GSK3β signaling pathway was reversed by the use of PI3K and/or GSK3β inhibitor.

Conclusions

In summary, our results demonstrated that improving glucose uptake, transport, and glycolysis in the brain may underlie the neuroprotective effects of SZL, and its potential molecular mechanism may be related to regulate the insulin signal transduction pathway.
The influence of climate change on food innovation technology: review on topical developments and legal framework
Authors: Ukhurebor Kingsley Eghonghon , Aidonojie Paul Atagamen
Published: December 2021

The influence of climate change on agriculture, especially as it relates to the production of food, changes with reverence to duration and space, of which most of these influences are diverse and remarkably uncertain. Undoubtedly, the application of food innovation technology (FIT) in the agricultural processes is an important response for operative and objective adaptation and mitigation of climate change. Consequently, there is a need to urgently re-evaluate the procedures for FIT so as to address the diversities and uncertainties ensuing from these influences of climate change on agriculture with the aim of improving the production of food. Therefore, the application of climate-smart agricultural (CSA) activities with resilience in agricultural events as well as more aids in the application of resources for both in the adaptation and mitigation of climate change by means of FIT will be of great assistance in this regard. Hence, this study presents a facile review of some of the topical developments in the production of food with reverence to the influence of climate change on FIT. Some legal frame-work on climate change with respect to FIT are also been discussed.
Effect of various additives on aluminum oxide thin films prepared by dip coating, thermal behavior, kinetics and optical properties
Authors: Bouzbib Mohammed , El Marouani Maryam , Sinkó Katalin
Published: December 2021

Aluminum oxide thin films attract research interest due to their properties. Aluminum acetate was used as an Al source with acetic acid, oxalic acid, and nitric acid as additives. The transmittance and the thickness of the films strongly depend on the additives, with the approximate bandgap energy changing from 5 ev to 5.4 ev. The aluminum oxide film deposited by dip-coating is presented great uniform surface morphology. The knowledge of the degradation kinetics of materials is essential for investigating the thermal stability of compounds. The acetic acid thin film proved to be the most efficient additive by demonstrating interesting optoelectronic properties. The thin films deposited by dip-coating were characterized by using X-ray grazing incidence diffraction, SEM, UV-Visible spectroscopy. Gamma aluminum oxide thin films prepared by acetic acid can be a good candidate for a wide range of optical applications.