bluuebunny/crossref_metadata_2025 huggingface dataset:
First-Principles Calculations to Investigate the Influence of Irradiation Defects on the Swelling Behavior of Fe-13Cr Alloys
Authors: Hu Yi-Yu , Xie Yao-Ping , Wu Lu , Qin Jian-Tao , Pan Rong-Jian , Yao Mei-Yi
Published: February 2022

Ferritic/martensitic (F/M) steels whose matrix is Fe-Cr are important candidate materials for fuel cladding of fast reactors, and they have excellent irradiation-swelling resistance. However, the mechanism of irradiation-swelling of F/M steels is still unclear. We use a first-principles method to reveal the influence of irradiation defects, i.e., Frenkel pair including atomic vacancy and self-interstitial atom, on the change of lattice volume of Fe-13Cr lattice. It is found that vacancy causes lattice contraction, while a self-interstitial atom causes lattice expansion. The overall effect of a Frenkel pair on the change of lattice volume is lattice expansion, leading to swelling of the alloy. Furthermore, the diffusion properties of point defects in Fe-13Cr are investigated. Based on the diffusion barriers of the vacancies and interstitial atoms, we find that the defects in Fe-13Cr drain out to surfaces/grain boundaries more efficiently than those in pure α-Fe do. Therefore, the faster diffusion of defects in Fe-13Cr is one of important factors for good swelling resistance of Fe-13Cr compared to pure α-Fe.
Antibacterial Properties of Biodegradable Silver Nanoparticle Foils Based on Various Strains of Pathogenic Bacteria Isolated from the Oral Cavity of Cats, Dogs and Horses
Authors: Rutkowski Miłosz , Krzemińska-Fiedorowicz Lidia , Khachatryan Gohar , Kabacińska Julia , Tischner Marek , Suder Aleksandra , Kulik Klaudia , Lenart-Boroń Anna
Published: February 2022

Frequent occurrence of microbial resistance to biocides makes it necessary to find alternative antimicrobial substances for modern veterinary medicine. The aim of this study was to obtain biodegradable silver nanoparticle-containing (AgNPs) foils synthesized using non-toxic chemicals and evaluation of their activity against bacterial pathogens isolated from oral cavities of cats, dogs and horses. Silver nanoparticle foils were synthesized using sodium alginate, and glucose, maltose and xylose were used as reducing agents. The sizes of AgNPs differed depending on the reducing agent used (xylose < maltose < glucose). Foil without silver nanoparticles was used as control. Bacterial strains were isolated from cats, dogs and horses by swabbing their oral cavities. Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and extended-spectrum beta-lactamase (ESBL) producing E. coli were isolated on selective chromogenic microbiological media. The bactericidal effect of AgNPs foils obtained using non-toxic chemical compounds against E. coli, ESBL, S. aureus and MRSA isolated from oral cavities of selected animals was confirmed in this study. No statistically significant differences were observed between the foils obtained with different reducing agents. Therefore, all types of examined foils proved to be effective against the isolated bacteria.
Multi-Objective Feeder Reconfiguration Using Discrete Particle Swarm Optimization
Authors: Noudjiep Djiepkop Giresse Franck , Krishnamurthy Senthil
Published: February 2022

Electric power distribution systems have been heavily engaged in evolutionary changes toward effective usage of distribution networks for dependability, quality, and improvement of services delivered to customers throughout the years. This was accomplished via a procedure known as reconfiguration. Several strategies have been offered by various authors for successful distribution feeder reconfiguration with a novel optimization method. As a result, this work developed a Discrete Particle Swarm Optimization (DPSO) method to address the issue of distribution system feeder reconfiguration during both steady-state and dynamic power system operations. In a dynamic state, the power demand and generation required are continually changing over time, and the DPSO algorithm finds a new set of solutions to fulfill the power demand. Many network topologies are investigated for the dynamic operation. The feeder reconfiguration single-objective optimization problem was transformed into a multi-objective optimization problem by taking into account both real power loss reduction and distribution system load balancing. The suggested technique was verified using various IEEE 16, 33, and 69 bus standard test distribution systems to determine the efficiency of the developed DPSO algorithm. The simulation findings reveal that DPSO outperforms other optimization algorithms in terms of actual power loss reduction and load balancing, while solving multi-objective distribution system feeder reconfiguration.
Patient-Centered Discussion on End-of-Life Care for Patients with Advanced COPD
Authors: Mitzel Holly , Brown Dakota , Thomas Morgan , Curl Byrne , Wild Mackenzie , Kelsch Andrea , Muskrat Judge , Hossain Abulquasem , Ryan Ken , Babalola Olawale , Burgard Madison , Mehedi Masfique
Published: February 2022

Exacerbations of chronic obstructive pulmonary disease (COPD) may lead to a rapid decline in health and subsequent death, an unfortunate tyranny of having COPD—an irreversible health condition of 16 million individuals in the USA totaling 60 million in the world. While COPD is the third largest leading cause of death, causing 3.23 million deaths worldwide in 2019 (according to the WHO), most patients with COPD do not receive adequate treatment at the end stages of life. Although death is inevitable, the trajectory towards end-of-life is less predictable in severe COPD. Thus, clinician-patient discussion for end-of-life and palliative care could bring a meaningful life-prospective to patients with advanced COPD. Here, we summarized the current understanding and treatment of COPD. This review also highlights the importance of patient-centered discussion and summarizes current status of managing patients with advanced COPD.
Formation of Nanowires of Various Types in the Process of Galvanic Deposition of Iron Group Metals into the Pores of a Track Membrane
Authors: Zagorskiy Dmitri , Doludenko Ilia , Zhigalina Olga , Khmelenin Dmitrii , Kanevskiy Vladimir
Published: February 2022

The processes of formation of one-dimensional nanostructures by the method of matrix synthesis was studied in this work. Nanowires (NWs) from magnetic metals of iron-group and copper (3-d metals) were synthesized in the pores of matrix-track membranes by galvanic deposition. NWs with both homogeneous elemental distribution (alloys) and with periodically alternating parts with different composition (layers) were obtained in matrices with different pore diameters and under different parameters of the galvanic process. The transport of ions, which determined the growth of wires, in pores of different sizes was analyzed. The influence of the size of pore channels on the features of NWs growth, the correlation between the elemental composition of the NWs and the growth electrolyte, as well as the influence of the growth conditions (voltage and pore diameter) were investigated. Approaches to formation of thin layers in layered NWs were studied. This included the choice of methods for controlling the pulse duration, slowing down the growth rate by the dilution of the solution, the use of additives and the work with reference electrode. The study of NWs was carried out using visualization and analysis of their structure using transmission and scanning electron microscopy, electron diffraction, energy dispersive analysis, and elemental mapping. For the studied types of samples, a relationship was established between the growth conditions and the structure. This data raises the possibility of varying the magnetic properties of NWs.
Effects of Heat Treatment on the Microstructure and Mechanical Properties of a Novel H-Grade Sucker Rod Steel
Authors: Tong Zhi , Zhou Guijuan , Zheng Wenyue , Zhang Haining , Zhou Hongyu , Sun Xiaoran
Published: February 2022

The sucker rod is an extremely important equipment in oil exploitation, but with the deepening and harsh environment of the petroleum well, higher requirements are put forward for the strength and corrosion resistance of the sucker rod. The most commonly used steel for H grade sucker rods is 4330 steel. However, it has characteristics such as high cost and relatively low sulfide stress cracking resistance. Thus, a novel sucker rod steel with a composition of 0.2 wt.% Cu and 1.2 wt.% Ni was designed. Normalizing + tempering (NT) and quenching + tempering (QT) heat treatment were optimized to render the mechanical properties of the novel sucker rod steel to reach the H grade. Additionally, effects of heat treatment on the microstructural evolution and mechanical properties of the novel sucker rod steel were investigated by optical microscope, scanning electron microscope and mechanical property tests. The results showed that the microstructure is tempered sorbite and the mechanical properties reach H grade after NT and QT. Specifically, the tensile strength, yield strength, elongation and impact toughness of NT/QT samples reached 1010.58/1124.37 MPa, 875.93/1042.63 MPa, 15.66/11.59% and ~77.48/~111.69 J/cm2, respectively. Furthermore, the finer and more dispersed carbides were observed in the QT sample, which means that the QT sample had better strength and toughness.
Identification of New Natural Sources of Flavour and Aroma Metabolites from Solid-State Fermentation of Agro-Industrial By-Products
Authors: Lindsay Melodie A. , Granucci Ninna , Greenwood David R. , Villas-Boas Silas G.
Published: February 2022

Increasing consumer demand for natural flavours and fragrances has driven up prices and increased pressure on natural resources. A shift in consumer preference towards more sustainable and economical sources of these natural additives and away from synthetic production has encouraged research into alternative supplies of these valuable compounds. Solid-state fermentation processes support the natural production of secondary metabolites, which represents most flavour and aroma compounds, while agro-industrial by-products are a low-value waste stream with a high potential for adding value. Accordingly, four filamentous fungi species with a history of use in the production of fermented foods and food additives were tested to ferment nine different agro-industrial by-products. Hundreds of volatile compounds were produced and identified using headspace (HS) solid-phase microextraction (SPME) coupled to gas chromatography–mass spectrometry (GC–MS). Four compounds of interest, phenylacetaldehyde, methyl benzoate, 1-octen-3-ol, and phenylethyl alcohol, were extracted and quantified. Preliminary yields were encouraging compared to traditional sources. This, combined with the low-cost substrates and the high-value natural flavours and aromas produced, presents a compelling case for further optimisation of the process.
An Experiment-Based Study of Formation Damage Using a Microetching Model Displacement Method
Authors: Wu Feng , Dai Jin , Shi Lei , Fan Lin , Guan Yao , Li Yuhan , Wang Qinghui , Chen Chunchao
Published: February 2022

In the field of oil and gas exploration, drilling fluid is regarded as the essential “blood” for drilling, which mainly helps to control the formation pressure and remove cuttings from the well. During the drilling fluid cycle, the drilling fluid penetrates into the pores of the formation rock, thus blocking the rock pores and resulting in a decline in oil and gas recovery efficiency. Therefore, it is very important to understand the microscopic mechanism of formation damage caused by drilling fluid. However, as an important component of formation damage, the microscopic mechanism of fluid damage has not yet been clearly revealed. In this study, a new microetching model (MEM), along with displacement equipment, was designed. The pore network of rock samples was extracted from thin-section images and etched to a thin aluminum sheet by laser. Oil-based drilling fluid was used to displace the stratum water in the MEM. The displacement process was recorded by a camera and analyzed. A core flooding experiment, permeability measurement, and SEM observations were performed. The results show that, for low-porosity and low-permeability sandstone, the main forms of formation damage by drilling fluid include solid damage and liquid damage. Solid damage is mainly caused by the blockage of small pores and narrow throats with solid particles of the size 0.1~30.0 μm in drilling fluid, while liquid damage is mainly caused by the water lock and hydrocarbon lock effects formed by the oil–water two-phase interface, gas–water two-phase interface, or the oil–gas–water three-phase interface.
A Review of Optical Imaging Technologies for Microfluidics
Authors: Zhou Pan , He Haipeng , Ma Hanbin , Wang Shurong , Hu Siyi
Published: February 2022

Microfluidics can precisely control and manipulate micro-scale fluids, and are also known as lab-on-a-chip or micro total analysis systems. Microfluidics have huge application potential in biology, chemistry, and medicine, among other fields. Coupled with a suitable detection system, the detection and analysis of small-volume and low-concentration samples can be completed. This paper reviews an optical imaging system combined with microfluidics, including bright-field microscopy, chemiluminescence imaging, spectrum-based microscopy imaging, and fluorescence-based microscopy imaging. At the end of the article, we summarize the advantages and disadvantages of each imaging technology.
Red Ghost Image Elimination Method Based on Driving Waveform Design in Three-Color Electrophoretic Displays
Authors: Wang Li , Zeng Wenjun , Liang Zhuopei , Zhou Guofu
Published: February 2022

Three-color electrophoretic displays (EPDs) are a new type of optoelectronic display device. However, they have the defect of red ghost images during gray scale transformation, which affects the accuracy of the gray scale display. In this paper, we proposed a new driving method for eliminating the red ghost images. A driving waveform was composed of an erasing stage, an activation stage, and a driving stage. First, the erasing stage was subdivided into a red erasing stage and an original erasing stage, the red erasing stage was used to eliminate residual red particles in the top of the microcapsules. Then, a high-frequency square wave was used as the activation stage for increasing the activity of the black and white particles. Meanwhile, the intensity of flickers could be decreased by the high-frequency square wave. Finally, the performance of the driving waveform was tested by a colorimeter. The experimental results showed that the driving waveform could effectively eliminate red ghost images by 80.43% and reduce the flicker intensity by 79.63%, compared with an existing driving waveform.
Phytoplankton Community Structure in Highly-Mineralized Small Gypsum Karst Lake (Russia)
Authors: Okhapkin Alexander , Sharagina Ekaterina , Kulizin Pavel , Startseva Natalja , Vodeneeva Ekaterina
Published: February 2022

Gypsum karst lakes are unique water ecosystems characterized by specific habitat conditions for living organisms, including phytoplankton species, as primary producers and mediating biogeochemical cycles in the water bodies. Studies of diversity and structure of phytoplankton communities can be used to identify the specific and typical lake features and plan basin-wide monitoring. The aim of this research was to analyze the structural variables of algocenoses in the small gypsum karstic Lake Klyuchik (Middle Volga basin), atypical for the subzone of mixed coniferous and deciduous forest zone high values of water mineralization (brackish water) and low temperatures. The lake has two water areas, connected by a shallow strait (ecotone zone) and differing from each other in the chemical compositions and physical properties of the water. A total of 133 species of phytoplankton with prevalence percentages of Bacillariophyta (46%), Chlorophyta (24%), and Ochrophyta (11%) were found; α-diversity varied from 4 to 30 specific and intraspecific taxa per sample. According to Spearman’s correlation coefficients, the diversity indices (Shannon, Pielou, Simpson) were mainly determined by the number of dominant species. The uniquely high (up to 130 g/m3) biomass of phytoplankton was noted in the ecotone, on the border between the water column and the bottom. The formation of mono- and oligo-dominant nannoplankton diatom communities with a predominance of the rare species Cyclotella distinguenda Hustedt was demonstrated there. The roles of flagellate algae and cyanobacteria were found to be less significant.
Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis
Authors: Wollanke Bettina , Gerhards Hartmut , Ackermann Kerstin
Published: February 2022

Uveitis is a sight-threatening eye disease in equids known worldwide that leads to considerable pain and suffering. By far the most common type of uveitis in Germany and neighboring countries is classical equine recurrent uveitis (ERU), which is caused by chronic intraocular leptospiral infection and is the main cause of infectious uveitis in horses. Other infectious causes are extremely rare and are usually clinically distinguishable from ERU. ERU can be treated very effectively by vitreous cavity lavage (vitrectomy). For proper indications of this demanding surgery, it is necessary to differentiate ERU from other types of uveitis in which vitrectomy is not helpful. This can be conducted on the basis of anamnesis in combination with ophthalmologic findings and by aqueous humor examination. During vitrectomy, vitreous material is obtained. These vitreous samples have historically been used for numerous etiologic studies. In this way, a chronic intraocular leptospiral infection has been shown to be the cause of typical ERU and, among other findings, ERU has also been recognized as a biofilm infection, providing new insights into the pathogenesis of ERU and explaining some thus far unexplainable phenomena of ERU. ERU may not only have transmissible aspects to some types of uveitis in humans but may also serve as a model for a spontaneously occurring biofilm infection. Vitreous material obtained during therapeutically indicated vitrectomy can be used for further studies on in vivo biofilm formation, biofilm composition and possible therapeutic approaches.
Adsorption and Fenton-like Degradation of Ciprofloxacin Using Corncob Biochar-Based Magnetic Iron–Copper Bimetallic Nanomaterial in Aqueous Solutions
Authors: Liu Hongrun , Liu Yuankun , Li Xing , Zheng Xiaoying , Feng Xiaoying , Yu Aixin
Published: February 2022

An economical corncob biochar-based magnetic iron–copper bimetallic nanomaterial (marked as MBC) was successfully synthesized and optimized through a co-precipitation and pyrolysis method. It was successfully used to activate H2O2 to remove ciprofloxacin (CIP) from aqueous solutions. This material had high catalytic activity and structural stability. Additionally, it had good magnetic properties, which can be easily separated from solutions. In MBC/H2O2, the removal efficiency of CIP was 93.6% within 360 min at optimal reaction conditions. The conversion of total organic carbon (TOC) reached 51.0% under the same situation. The desorption experiments concluded that adsorption and catalytic oxidation accounted for 34% and 66% on the removal efficiency of CIP, respectively. The influences of several reaction parameters were systematically evaluated on the catalytic activity of MBC. OH was proved to play a significant role in the removal of CIP through electron paramagnetic resonance (EPR) analysis and a free radical quenching experiment. Additionally, such outstanding removal efficiency can be attributed to the excellent electronic conductivity of MBC, as well as the redox cycle reaction between iron and copper ions, which achieved the continuous generation of hydroxyl radicals. Integrating HPLC-MS, ion chromatography and density functional theory (DFT) calculation results, and possible degradation of the pathways of the removal of CIP were also thoroughly discussed. These results provided a theoretical basis and technical support for the removal of CIP in water.
The Dietary Supplement Creatyl-l-Leucine Does Not Bioaccumulate in Muscle, Brain or Plasma and Is Not a Significant Bioavailable Source of Creatine
Authors: da Silva Robin P.
Published: February 2022

Creatine is an important energy metabolite that is concentrated in tissues such as the muscles and brain. Creatine is reversibly converted to creatine phosphate through a reaction with ATP or ADP, which is catalyzed by the enzyme creatine kinase. Dietary supplementation with relatively large amounts of creatine monohydrate has been proven as an effective sports supplement that can enhances athletic performance during acute high-energy demand physical activity. Some side effects have been reported with creatine monohydrate supplementation, which have stimulated research into new potential molecules that could be used as supplements to potentially provide bioavailable creatine. Recently, a popular supplement, creatyl-l-leucine, has been proposed as a potential dietary ingredient that may potentially provide bioavailable creatine. This study tests whether creatyl-l-leucine is a bioavailable compound and determines whether it can furnish creatine as a dietary supplement. Rats were deprived of dietary creatine for a period of two weeks and then given one of three treatments: a control AIN-93G creatine-free diet, AIN-93G supplemented with creatine monohydrate or AIN-93G with an equimolar amount of creatyl-l-leucine supplement in the diet for one week. When compared to the control and the creatine monohydrate-supplemented diet, creatyl-l-leucine supplementation resulted in no bioaccumulation of either creatyl-l-leucine or creatine in tissue.
Effects of Thiamin Restriction on Exercise-Associated Glycogen Metabolism and AMPK Activation Level in Skeletal Muscle
Authors: Sato Akiko , Sato Shinji , Omori Go , Koshinaka Keiichi
Published: February 2022

This study aimed to investigate the direct influence of a decrease in the cellular thiamin level, before the onset of anorexia (one of the symptoms of thiamin deficiency) on glycogen metabolism and the AMP-activated protein kinase (AMPK) activation levels in skeletal muscle at rest and in response to exercise. Male Wistar rats were classified as the control diet (CON) group or the thiamin-deficient diet (TD) group and consumed the assigned diets for 1 week. Skeletal muscles were taken from the rats at rest, those that underwent low-intensity swimming (LIS), or high-intensity intermittent swimming (HIS) conducted immediately before dissection. There were no significant differences in food intake, locomotive activity, or body weight between groups, but thiamin pyrophosphate in the skeletal muscles of the TD group was significantly lower than that of the CON group. Muscle glycogen and lactate levels in the blood and muscle were equivalent between groups at rest and in response to exercise. The mitochondrial content was equal between groups, and AMPK in the skeletal muscles of TD rats was normally activated by LIS and HIS. In conclusion, with a lowered cellular thiamin level, the exercise-associated glycogen metabolism and AMPK activation level in skeletal muscle were normally regulated.
Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress
Authors: Pereira Evelyn Nunes Goulart da Silva , Araujo Beatriz Peres de , Rodrigues Karine Lino , Silvares Raquel Rangel , Martins Carolina Souza Machado , Flores Edgar Eduardo Ilaquita , Fernandes-Santos Caroline , Daliry Anissa
Published: February 2022

Increased reactive oxidative stress, lipid peroxidation, inflammation, and fibrosis, which contribute to tissue damage and development and progression of nonalcoholic liver disease (NAFLD), play important roles in microcirculatory disorders. We investigated the effect of the modulatory properties of simvastatin (SV) on the liver and adipose tissue microcirculation as well as metabolic and oxidative stress parameters, including the advanced lipoxidation end product–receptors of advanced glycation end products (ALE-RAGE) pathway. SV was administered to an NAFLD model constructed using a high-fat–high-carbohydrate diet (HFHC). HFHC caused metabolic changes indicative of nonalcoholic steatohepatitis; treatment with SV protected the mice from developing NAFLD. SV prevented microcirculatory dysfunction in HFHC-fed mice, as evidenced by decreased leukocyte recruitment to hepatic and fat microcirculation, decreased hepatic stellate cell activation, and improved hepatic capillary network architecture and density. SV restored basal microvascular blood flow in the liver and adipose tissue and restored the endothelium-dependent vasodilatory response of adipose tissue to acetylcholine. SV treatment restored antioxidant enzyme activity and decreased lipid peroxidation, ALE-RAGE pathway activation, steatosis, fibrosis, and inflammatory parameters. Thus, SV may improve microcirculatory function in NAFLD by downregulating oxidative and ALE-RAGE stress and improving steatosis, fibrosis, and inflammatory parameters.
Betaine Supplementation Attenuates S-Adenosylhomocysteine Hydrolase-Deficiency-Accelerated Atherosclerosis in Apolipoprotein E-Deficient Mice
Authors: Dai Xin , Liu Si , Cheng Lokyu , Huang Ting , Guo Honghui , Wang Dongliang , Xia Min , Ling Wenhua , Xiao Yunjun
Published: February 2022

S-adenosylhomocysteine (SAH) is a risk factor of cardiovascular diseases and atherosclerosis. However, the causal association between SAH and atherosclerosis is still uncertain. In the present study, heterozygous SAH hydrolase (SAHH+/−) knockout mice were bred with apolipoprotein E-deficient mice to produce ApoE−/−/SAHH+/− mice. At 8 weeks of age, these mice were fed on AIN-93G diets added with or without betaine (4 g betaine/100 g diet) for 8 weeks. Compared with ApoE−/−/SAHHWT mice, SAHH deficiency caused an accumulation of plasma SAH concentration and a decrease in S-adenosylmethionine (SAM)/SAH ratio as well as plasma homocysteine levels. Betaine supplementation lowered SAH levels and increased SAM/SAH ratio and homocysteine levels in ApoE−/−/SAHH+/− mice. Furthermore, SAHH deficiency promoted the development of atherosclerosis, which was reduced by betaine supplementation. The atheroprotective effects of betaine on SAHH-deficiency-promoted atherosclerosis were associated with inhibition of NFκB inflammation signaling pathway and inhibition of proliferation and migration of smooth muscle cells. In conclusion, our results suggest that betaine supplementation lowered plasma SAH levels and protected against SAHH-deficiency-promoted atherosclerosis through repressing inflammation and proliferation and migration of smooth muscle cells.
Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut
Authors: Friedrich Adrián D. , Leoni Juliana , Paz Mariela L. , González Maglio Daniel H.
Published: February 2022

Lipoteichoic acid (LTA) from Gram-positive bacteria exerts different immune effects depending on the bacterial source from which it is isolated. Lacticaseibacillus rhamnosus GG LTA (LGG-LTA) oral administration reduces UVB-induced immunosuppression and skin tumor development in mice. In the present work, we evaluate the immunomodulatory effect exerted by LGG-LTA in dendritic cells (DC) and T cells, both in vitro and in the gut-associated lymphoid tissue (GALT). During cell culture, LTA-stimulated BMDC increased CD86 and MHC-II expression and secreted low levels of pro and anti-inflammatory cytokines. Moreover, LTA-treated BMDC increased T cell priming capacity, promoting the secretion of IL-17A. On the other hand, in orally LTA-treated mice, a decrease in mature DC (lamina propria and Peyer’s patches) was observed. Concomitantly, an increase in IL-12p35 and IFN-γ transcription was presented (lamina propria and Peyer’s Patches). Finally, an increase in the number of CD103+ DC was observed in Peyer’s patches. Together, our data demonstrate that LGG-LTA activates DC and T cells. Moreover, we show that a Th1-biased immune response is triggered in vivo after oral LTA administration. These effects justify the oral LTA activity previously observed.
Psychometric Properties of the Self-Compassion Scale—Short Form: Study of Its Role as a Protector of Spanish Nurses Professional Quality of Life and Well-Being during the COVID-19 Pandemic
Authors: Lluch-Sanz Cristina , Galiana Laura , Vidal-Blanco Gabriel , Sansó Noemí
Published: February 2022

Self-compassion is a multifaceted construct that represents compassion turned inward and involves approaching one’s failure and inadequacy with kindness. To measure these self-compassionate behaviors, the Self-Compassion Scale—Short Form (SCS-SF) is one of the most widely used and has been recurrently employed in the healthcare arena. Specifically, self-compassion has been pointed out as essential for providing compassionate care and maintaining healthcare workers balance. Aim: The aim of this study is twofold: (1) to provide evidence of the psychometric properties of the SCS-SF in a sample of Spanish nurses and (2) to study of its role as a protector of Spanish nurses professional quality of life and well-being during the COVID-19 pandemic. Methods: A sample of 115 Spanish nurses was studied. Mean age was 43.79 years old (SD = 10.99); 84.3% were women. The factorial structure of the SCS-SF was studied with competitive confirmatory factor analysis (CFA). Finally, a full structural equation model was tested, in which positive and negative self-compassion predicted professional quality of life, and professional quality of life, in turn, predicted well-being. Results: Three a priori structures were compared: one-factor, two-factor, and six-factor model. The two-factor solution, positive and negative self-compassion, was retained as the best structure to represent the data. Regarding the predictive model, the two poles of self-compassion predicted professional quality of life prediction, and professional quality of life positively predicted well-being, showing a strong relationship. Conclusion: Self-compassion can be an important resource for nurses’ balance, promoting adequate professional quality of life and their well-being.
Anticoronaviral Activity of the Natural Phloroglucinols, Dryocrassin ABBA and Filixic Acid ABA from the Rhizome of Dryopteris crassirhizoma by Targeting the Main Protease of SARS-CoV-2
Authors: Jin Young-Hee , Jeon Sangeun , Lee Jihye , Kim Seungtaek , Jang Min Seong , Park Chul Min , Song Jong Hwan , Kim Hyoung Rae , Kwon Sunoh
Published: February 2022

The rhizome of Dryopteris crassirhizoma Nakai. (Dryopteridaceae) has been used in traditional medicine in East Asia and has recently been reported to have anticancer, anti-inflammation, and antibacterial activity as well as antiviral activity. Natural phloroglucinols from D. crassirhizoma, dryocrassin ABBA and filixic acid ABA were reported to inhibit influenza virus infection with an inhibitory activity on neuraminidase. In this study, we found that dryocrassin ABBA and filixic acid ABA have an inhibitory activity against the main protease of SARS-CoV-2. Therefore, dryocrassin ABBA and filixic acid ABA exhibited inhibitory activity against SARS-CoV-2 infection in Vero cells dose-dependently using the immunofluorescence-based antiviral assays. Moreover, these compounds inhibited SARS-CoV and MERS-CoV infection, suggesting their broad-spectrum anticoronaviral activity. In addition, a 5-day repeated-dose toxicity study of dryocrassin ABBA and filixic acid ABA suggested that an approximately lethal dose of these compounds in mice was >10 mg/kg. Pharmacokinetic studies of dryocrassin ABBA showed good microsomal stability, low hERG inhibition, and low CYP450 inhibition. In vivo pharmacokinetic properties of dryocrassin ABBA showed a long half-life (5.5–12.6 h) and high plasma exposure (AUC 19.3–65 μg·h/mL). Therefore, dryocrassin ABBA has therapeutic potential against emerging coronavirus infections, including COVID-19.
Plant Extract-Synthesized Silver Nanoparticles for Application in Dental Therapy
Authors: Ahmed Omnia , Sibuyi Nicole Remaliah Samantha , Fadaka Adewale Oluwaseun , Madiehe Madimabe Abram , Maboza Ernest , Meyer Mervin , Geerts Greta
Published: February 2022

Oral diseases are the most common non-communicable diseases in the world, with dental caries and periodontitis causing major health and social problems. These diseases can progress to systematic diseases and cause disfigurement when left untreated. However, treatment of oral diseases is among the most expensive treatments and often focus on restoration of form and function. Caries prevention has traditionally relied on oral hygiene and diet control, among other preventive measures. In this paper, these measures are not disqualified but are brought into a new context through the use of nanotechnology-based materials to improve these conventional therapeutic and preventive measures. Among inorganic nanomaterials, silver nanoparticles (AgNPs) have shown promising outcomes in dental therapy, due to their unique physicochemical properties and enhanced anti-bacterial activities. As such, AgNPs may provide newer strategies for treatment and prevention of dental infections. However, numerous concerns around the chemical synthesis of nanomaterials, which are not limited to cost and use of toxic reducing agents, have been raised. This has inspired the green synthesis route, which uses natural products as reducing agents. The biogenic AgNPs were reported to be biocompatible and environmentally friendly when compared to the chemically-synthesized AgNPs. As such, plant-synthesized AgNPs can be used as antimicrobial, antifouling, and remineralizing agents for management and treatment of dental infections and diseases.
The Birth of the Universe as a Result of the Change of the Metric Signature
Authors: Shestakova Tatyana P.
Published: February 2022

In this paper, I discuss the idea that the birth of our Universe may be a result of a quantum transition from a physical continuum with the Euclidean signature to a Lorentzian spacetime. A similar idea was expressed by Andrei D. Sakharov At the classical level, the idea was studied by George F. R. Ellis and his collaborators, who explored if solutions to the classical Einstein equation exist which admit a change of metric signature. The present paper aims at examining possible realizations of this idea at the level of quantum gravity, in the framework of the Wheeler–DeWitt theory and in the extended phase space approach to quantization of gravity. I intend to answer the questions: to answer the questions: Does the Hartle–Hawking wave function imply such a realization? How can this idea be realized in the extended phase space approach to quantum gravity, where the change of signature is described by imposing special conditions on g00-component of the metric in different regions of the physical continuum? The conclusion is that the idea can be realized from a formal mathematical point of view, but it can hardly help in understanding how spacetime structure and time itself appeared from a timeless continuum.
Finding Mesolithic Sites: A Multichannel Ground-Penetrating Radar (GPR) Investigation at the Ancient Lake Duvensee
Authors: Corradini Erica , Groß Daniel , Wunderlich Tina , Lübke Harald , Wilken Dennis , Erkul Ercan , Schmölcke Ulrich , Rabbel Wolfgang
Published: February 2022

The shift to the early Holocene in northern Europe is strongly associated with major environmental and climatic changes that influenced hunter-gatherers’ activities and occupation during the Mesolithic period. The ancient lake Duvensee (10,000–6500 cal. BCE) has been studied for almost a century, providing archaeological sites consisting of bark mats and hazelnut-roasting hearths situated on small sand banks deposited by the glacier. No method is yet available to locate these features before excavation. Therefore, a key method for understanding the living conditions of hunter-gatherer groups is to reconstruct the paleoenvironment with a focus on the identification of areas that could possibly host Mesolithic camps and well-preserved archaeological artefacts. We performed a 16-channel MALÅ Imaging Radar Array (MIRA) system survey aimed at understanding the landscape surrounding the find spot Duvensee WP10, located in a hitherto uninvestigated part of the bog. Using an integrated approach of high-resolution ground radar mapping and targeted excavations enabled us to derive a 3D spatio-temporal landscape reconstruction of the investigated sector, including paleo-bathymetry, stratigraphy, and shorelines around the Mesolithic camps. Additionally, we detected previously unknown islands as potential areas for yet unknown dwelling sites. We found that the growth rates of the islands were in the order of approximately 0.3 m2/yr to 0.7 m2/yr between the late Preboreal and the Subboreal stages. The ground-penetrating radar surveying performed excellently in all aspects of near-surface landscape reconstruction as well as in identifying potential dwellings; however, the direct identification of small-scale artefacts, such as fireplaces, was not successful because of their similarity to natural structures.
Integration of DInSAR Time Series and GNSS Data for Continuous Volcanic Deformation Monitoring and Eruption Early Warning Applications
Authors: Corsa Brianna , Barba-Sevilla Magali , Tiampo Kristy , Meertens Charles
Published: February 2022

With approximately 800 million people globally living within 100 km of a volcano, it is essential that we build a reliable observation system capable of delivering early warnings to potentially impacted nearby populations. Global Navigation Satellite System (GNSS) and satellite Synthetic Aperture Radar (SAR) document comprehensive ground motions or ruptures near, and at, the Earth’s surface and may be used to detect and analyze natural hazard phenomena. These datasets may also be combined to improve the accuracy of deformation results. Here, we prepare a differential interferometric SAR (DInSAR) time series and integrate it with GNSS data to create a fused dataset with enhanced accuracy of 3D ground motions over Hawaii island from November 2015 to April 2021. We present a comparison of the raw datasets against the fused time series and give a detailed account of observed ground deformation leading to the May 2018 and December 2020 volcanic eruptions. Our results provide important new estimates of the spatial and temporal dynamics of the 2018 Kilauea volcanic eruption. The methodology presented here can be easily repeated over any region of interest where an SAR scene overlaps with GNSS data. The results will contribute to diverse geophysical studies, including but not limited to the classification of precursory movements leading to major eruptions and the advancement of early warning systems.
Genetic Programming Approach for the Detection of Mistletoe Based on UAV Multispectral Imagery in the Conservation Area of Mexico City
Authors: Mejia-Zuluaga Paola Andrea , Dozal León , Valdiviezo-N. Juan C.
Published: February 2022

The mistletoe Phoradendron velutinum (P. velutinum) is a pest that spreads rapidly and uncontrollably in Mexican forests, becoming a serious problem since it is a cause of the decline of 23.3 million hectares of conifers and broadleaves in the country. The lack of adequate phytosanitary control has negative social, economic, and environmental impacts. However, pest management is a challenging task due to the difficulty of early detection for proper control of mistletoe infestations. Automating the detection of this pest is important due to its rapid spread and the high costs of field identification tasks. This paper presents a Genetic Programming (GP) approach for the automatic design of an algorithm to detect mistletoe using multispectral aerial images. Our study area is located in a conservation area of Mexico City, in the San Bartolo Ameyalco community. Images of 148 hectares were acquired by means of an Unmanned Aerial Vehicle (UAV) carrying a sensor sensitive to the R, G, B, red edge, and near-infrared bands, and with an average spatial resolution of less than 10 cm per pixel. As a result, it was possible to obtain an algorithm capable of classifying mistletoe P. velutinum at its flowering stage for the specific case of the study area in conservation area with an Overall Accuracy (OA) of 96% and a value of fitness function based on weighted Cohen’s Kappa (kw) equal to 0.45 in the test data set. Additionally, our method’s performance was compared with two traditional image classification methods; in the first, a classical spectral index, named Intensive Pigment Index of Structure 2 (SIPI2), was considered for the detection of P. velutinum. The second method considers the well-known Support Vector Machine classification algorithm (SVM). We also compare the accuracy of the best GP individual with two additional indices obtained during the solution analysis. According to our experimental results, our GP-based algorithm outperforms the results obtained by the aforementioned methods for the identification of P. velutinum.
Spatiotemporal Hybrid Random Forest Model for Tea Yield Prediction Using Satellite-Derived Variables
Authors: Jui S Janifer Jabin , Ahmed A. A. Masrur , Bose Aditi , Raj Nawin , Sharma Ekta , Soar Jeffrey , Chowdhury Md Wasique Islam
Published: February 2022

Crop yield forecasting is critical for enhancing food security and ensuring an appropriate food supply. It is critical to complete this activity with high precision at the regional and national levels to facilitate speedy decision-making. Tea is a big cash crop that contributes significantly to economic development, with a market of USD 200 billion in 2020 that is expected to reach over USD 318 billion by 2025. As a developing country, Bangladesh can be a greater part of this industry and increase its exports through its tea yield and production with favorable climatic features and land quality. Regrettably, the tea yield in Bangladesh has not increased significantly since 2008 like many other countries, despite having suitable climatic and land conditions, which is why quantifying the yield is imperative. This study developed a novel spatiotemporal hybrid DRS–RF model with a dragonfly optimization (DR) algorithm and support vector regression (S) as a feature selection approach. This study used satellite-derived hydro-meteorological variables between 1981 and 2020 from twenty stations across Bangladesh to address the spatiotemporal dependency of the predictor variables for the tea yield (Y). The results illustrated that the proposed DRS–RF hybrid model improved tea yield forecasting over other standalone machine learning approaches, with the least relative error value (11%). This study indicates that integrating the random forest model with the dragonfly algorithm and SVR-based feature selection improves prediction performance. This hybrid approach can help combat food risk and management for other countries.
Leveraging Multi-Source Data and Digital Technology to Support the Monitoring of Localized Water Changes in the Mekong Region
Authors: Polpanich Orn-uma , Bhatpuria Dhyey , Santos Santos Tania Fernanda , Krittasudthacheewa Chayanis
Published: February 2022

The limited availability of high-resolution monitoring systems for the drought phenomena and water dynamics affected by weather anomalies hinders policy decisions in a multitude of ways. This paper introduces the availability of the high-resolution Water Monitoring System (WMS) developed from a mix of sophisticated multi-spectral satellite imageries, analytic and data sciences, and cloud computing, for monitoring the changes in water levels and vegetation water stress at the local scale. The WMS was tested in the Lower Mekong Region (LMR) case basin, Thailand’s Chi River Basin, in the period from January 2021 to April 2021, the dry season. The overall quality of the VHI, VCI, TCI, and NDVI drought simulation results showed a statistically positive Pearson correlation with the reservoir and dam water volume data (ranged between 0.399 and 0.575) but demonstrated a strong negative correlation with the groundwater level data (between −0.355 and −0.504). Further investigation and more detailed analysis of the influence of different physical environmental conditions related to change in groundwater level should be considered to increase scientific knowledge and understanding about the changing nature of the local system from local perspectives with the alternative use of drought indices in data-poor areas. Our result suggests that the WMS can provide quantitative spatiotemporal variations of localized and contextualized surface water changes as a preliminary analysis. The WMS results can offer guidance for finding a better smaller unit management that suits the local conditions, such as water resource management, disaster risk reduction measures (i.e., drought and flood), irrigation practice, land use planning, and crop management. The existing WMS is geared toward the early warning of water and agricultural development, progress on the SDGs, utilization of digital innovation, and improved abilities of decision-makers to monitor and foresee extreme weather events earlier and with high spatial accuracy.
Foreign Shareholders’ Social Responsibility, R&D Innovation, and International Competitiveness of Chinese SOEs
Authors: Zhou Yuying , Lei Chu , Jiménez Alfredo
Published: February 2022

Despite the increasing use of mixed ownership (domestic and foreign shareholders) in Chinese state-owned enterprises (SOEs), the role and performance of foreign ownership is still a controversial topic. In this paper we empirically examine the effects of foreign shareholders’ social responsibility on the international competitiveness of SOEs and the moderating effect of R&D innovation. Drawing on a sample of Chinese listed SOEs with international market operations over the period 2011–2019, we find empirical evidence supporting that foreign shareholders’ social responsibility is effective in enhancing the international competitiveness of Chinese SOEs. We also find that R&D innovation strengthens the effect between foreign shareholders’ social responsibility and enterprises’ international competitiveness. These findings are valid after controlling for robustness and endogeneity factors. Furthermore, we find that the promoting effect of foreign shareholders’ social responsibility on Chinese SOEs’ international competitiveness, as well as the moderating effect of R&D innovation, is more pronounced among Chinese local SOEs, business SOEs, and manufacturing SOEs. The research in this paper contributes to the current debate and deepens our understanding regarding the role and performance of foreign shareholders in the process of mixed-ownership reform.
Forest Education with the Use of Educational Infrastructure in the Opinion of the Public-Experience from Poland
Authors: Korcz Natalia , Janeczko Emilia
Published: February 2022

In Poland, informal forest education is carried out mostly on forest educational paths, equipped with educational boards. Due to the diverse audience, an attempt was made to assess the elements supporting forest education from the perspective of forest users. The aim of the study is to determine the basic criteria that, in the opinion of path users, determine the use, attractiveness, and importance of educational boards in education. In an anonymous questionnaire, 504 people participated during meetings with an educator on paths in forests of the Regional Directorate of the State Forests in Lublin. In the opinion of trail users, boards are not an important element that should be present on educational trails; in their opinion, they moderately support informal forest education activities. Users generally paid attention to between one to two or three to four boards. The attractiveness of the boards is determined by the graphics of the whole board. Respondents would also prefer boards on which information is presented in graphical rather than text form. Our study indicates a somewhat negative perception of educational boards in forest education, which has prompted the authors to conduct further research in order to clarify forest users’ perceptions of the issues analyzed.