bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional Connectivity of Language-Related Cerebellar Regions Is Reduced in Schizophrenia Patients
Authors: Marino Marco , Biondi Margherita , Mantini Dante , Spironelli Chiara
Published: February 2024

Schizophrenia (SZ) is a widespread psychiatric disorder that is traditionally characterized by positive and negative symptoms. However, recent focus has shifted to cognitive deficits as a crucial aspect. The cerebellum, conventionally tied to motor coordination, is now recognized as pivotal in the pathophysiology of SZ cognitive impairments. Proposed disruptions in the cortico-cerebellar-thalamic-cortico circuit contribute to these deficits. Despite evidence of cerebellar abnormalities, within-cerebellum functional connectivity is often overlooked. This study explores spontaneous functional interactions within the cerebellum and their link to cognitive deficits in SZ. Using a multi-domain task battery (MDTB) parcellation, fMRI data from SZ patients and healthy controls were analyzed. Significant differences in cerebellar connectivity emerged, particularly in regions related to attention, language, and memory processing. Correlations between connectivity values and SZ symptomatology were identified. A post hoc analysis, considering the patients’ hallucination vulnerability, revealed distinct connectivity patterns. Non-hallucinating and low-hallucinating SZ patients exhibited higher cerebellar connectivity than high-hallucinating patients, especially in language and motor control regions. These findings suggest a gradient of cerebellar connectivity alterations corresponding to hallucination vulnerability in SZ patients. This study offers novel insights into cerebellar impairments in SZ, highlighting the role of within-cerebellum connectivity in cognitive deficits. The observed connectivity patterns in language-related regions contribute to understanding language development and auditory verbal hallucinations in SZ.
Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review
Authors: Ortego-Isasa Iñaki , Ortega-Morán Juan Francisco , Lozano Héctor , Stieglitz Thomas , Sánchez-Margallo Francisco M. , Usón-Gargallo Jesús , Pagador J. Blas , Ramos-Murguialday Ander
Published: February 2024

Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.
Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness
Authors: Carrano Raffaele , Grande Martina , Leti Maggio Eleonora , Zucca Carlotta , Bei Riccardo , Palumbo Camilla , Focaccetti Chiara , Nardozi Daniela , Lucarini Valeria , Angiolini Valentina , Mancini Patrizia , Barberini Francesca , Barillari Giovanni , Cifaldi Loredana , Masuelli Laura , Benvenuto Monica , Bei Roberto
Published: February 2024

Focal adhesion plaques (FAPs) play an important role in the communication between cells and the extracellular matrix (ECM) and in cells’ migration. FAPs are macromolecular complexes made by different proteins which also interact with matrix metalloproteinases (MMPs). Because of these fundamental properties, FAPs and MMPs are also involved in cancer cells’ invasion and in the metastatic cascade. The most important proteins involved in FAP formation and activity are (i) integrins, (ii) a complex of intracellular proteins and (iii) cytoskeleton proteins. The latter, together with MMPs, are involved in the formation of filopodia and invadopodia needed for cell movement and ECM degradation. Due to their key role in cancer cell migration and invasion, MMPs and components of FAPs are often upregulated in cancer and are thus potential targets for cancer therapy. Polyphenols, a large group of organic compounds found in plant-based food and beverages, are reported to have many beneficial healthy effects, including anticancer and anti-inflammatory effects. In this review, we discuss the growing evidence which demonstrates that polyphenols can interact with the different components of FAPs and MMPs, inhibit various pathways like PI3K/Akt, lower focal adhesion kinase (FAK) phosphorylation and decrease cancer cells’ invasiveness, leading to an overall antitumoral effect. Finally, here we highlight that polyphenols could hold potential as adjunctive therapies to conventional cancer treatments due to their ability to target key mechanisms involved in cancer progression.
Genistein and Sex Hormone Supplementation Modulated Hepatic PPARα, δ, and γ Subtypes and STAT1 Expressions in a NASH Rat Model with Bilateral Orchidectomy
Authors: Okrit Fatist , Chayanupatkul Maneerat , Siriviriyakul Prasong , Wanpiyarat Natcha , Werawatganon Duangporn
Published: February 2024

Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic inflammation and steatosis. Currently, limited data exist regarding the risk of NASH in transgender women and the treatment options for this particular population. The use of testosterone supplementation is unfavorable for transgender women, and estrogen supplementation is linked to an increased risk of breast cancer; thus, an isoflavone derivative compound known as “genistein” could serve as a viable substitute for a hormone supplement in this context. The purpose of this study was to investigate the treatment effects and mechanisms of actions of genistein and sex hormones in orchidectomized (ORX) rats with nonalcoholic steatohepatitis induced via a high-fat high-fructose diet (HFHF) model. Male Sprague-Dawley rats (n = 42) were randomly assigned into seven groups; control, ORX + standard diet, HFHF, ORX + HFHF, ORX + HFHF diet + testosterone (50 mg/kg body weight (BW) once weekly), ORX + HFHF diet + estradiol (1.6 mg/kg BW daily), and ORX + HFHF diet + genistein (16 mg/kg BW daily). The duration of the study was 6 weeks. Some parts of liver tissue were used for histological examination by H&E staining. The determination of fat accumulation was performed using Oil Red O staining. SREBP1c and FAS gene expression were quantified using real-time PCR technique. The levels of all types of peroxisome proliferator-activated receptors (PPARs; α, δ, γ), proteins, and signal transducer and activator of transcription 1 (STAT1) signaling pathway were determined by both immunoblotting and immunohistochemistry. Rats in the ORX + HFHF group had the highest degree of hepatic steatosis, lobular inflammation, and hepatocyte ballooning, and showed higher levels of genes related to de novo lipogenesis, including SREBP1c and FAS. The expression of PPARγ and STAT1 were upregulated, while the expression of PPARα and PPARδ were downregulated in the ORX + HFHF group. Testosterone, estradiol and genistein treatments improved NASH histopathology together with the reversal of all types of PPAR protein expressions. Interestingly, genistein decreased the levels of STAT1 protein expression more than those of testosterone and estradiol treatment. Genistein and sex hormone treatment could ameliorate NASH through the upregulation of PPARα, and PPARδ, and the suppression of PPARγ and STAT1 expression.
A Hierarchical Prediction Method for Pedestrian Head Injury in Intelligent Vehicle with Combined Active and Passive Safety System
Authors: Shi Liangliang , Zhang Honghao , Wu Lintao , Liu Yu , Cheng Kuo , Han Yong , Wang Danqi
Published: February 2024

With the development of intelligent vehicle technology, the probability of road traffic accidents occurring has been effectively reduced to a certain extent. However, there is still insufficient research on head injuries in human vehicle collisions, making it impossible to effectively predict pedestrian head injuries in accidents. To study the efficacy of a combined active and passive safety system on pedestrian head protection through the combined effect of the exterior airbag and the braking control systems of an intelligent vehicle, a “vehicle–pedestrian” interaction system is constructed in this study and is verified by real collision cases. On this basis, a combined active and passive system database is developed to analyze the cross-influence of the engine hood airbag and the vehicle braking curve parameters on pedestrian HIC (head injury criterion). Meanwhile, a hierarchy design strategy for a combined active and passive system is proposed, and a rapid prediction of HIC is achieved via the establishment of a fitting equation for each grading. The results show that the exterior airbag can effectively protect the pedestrian’s head, prevent the collision between the pedestrian’s head and the vehicle front structure, and reduce the HIC. The braking parameter H2 is significantly correlated with head injury, and when H2 is less than 1.8, the HIC value is less than 1000 in nearly 90% of cases. The hierarchy design strategy and HIC prediction method of the combined active and passive system proposed in this paper can provide a theoretical basis for rapid selection and parameter design.
Toward the Intelligent, Safe Exploration of a Biomimetic Underwater Robot: Modeling, Planning, and Control
Authors: Wang Yu , Wang Jian , Yu Lianyi , Kong Shihan , Yu Junzhi
Published: February 2024

Safe, underwater exploration in the ocean is a challenging task due to the complex environment, which often contains areas with dense coral reefs, uneven terrain, or many obstacles. To address this issue, an intelligent underwater exploration framework of a biomimetic robot is proposed in this paper, including an obstacle avoidance model, motion planner, and yaw controller. Firstly, with the aid of the onboard distance sensors in robotic fish, the obstacle detection model is established. On this basis, two types of obstacles, i.e., rectangular and circular, are considered, followed by the obstacle collision model’s construction. Secondly, a deep reinforcement learning method is adopted to plan the plane motion, and the performances of different training setups are investigated. Thirdly, a backstepping method is applied to derive the yaw control law, in which a sigmoid function-based transition method is employed to smooth the planning output. Finally, a series of simulations are carried out to verify the effectiveness of the proposed method. The obtained results indicate that the biomimetic robot can not only achieve intelligent motion planning but also accomplish yaw control with obstacle avoidance, offering a valuable solution for underwater operation in the ocean.
Bioinspired Stimuli-Responsive Materials for Soft Actuators
Authors: Wang Zhongbao , Chen Yixin , Ma Yuan , Wang Jing
Published: February 2024

Biological species can walk, swim, fly, jump, and climb with fast response speeds and motion complexity. These remarkable functions are accomplished by means of soft actuation organisms, which are commonly composed of muscle tissue systems. To achieve the creation of their biomimetic artificial counterparts, various biomimetic stimuli-responsive materials have been synthesized and developed in recent decades. They can respond to various external stimuli in the form of structural or morphological transformations by actively or passively converting input energy into mechanical energy. They are the core element of soft actuators for typical smart devices like soft robots, artificial muscles, intelligent sensors and nanogenerators. Significant progress has been made in the development of bioinspired stimuli-responsive materials. However, these materials have not been comprehensively summarized with specific actuation mechanisms in the literature. In this review, we will discuss recent advances in biomimetic stimuli-responsive materials that are instrumental for soft actuators. Firstly, different stimuli-responsive principles for soft actuators are discussed, including fluidic, electrical, thermal, magnetic, light, and chemical stimuli. We further summarize the state-of-the-art stimuli-responsive materials for soft actuators and explore the advantages and disadvantages of using electroactive polymers, magnetic soft composites, photo-thermal responsive polymers, shape memory alloys and other responsive soft materials. Finally, we provide a critical outlook on the field of stimuli-responsive soft actuators and emphasize the challenges in the process of their implementation to various industries.
A Bio-Inspired Approach to Improve the Toughness of Brittle Bast Fibre-Reinforced Composites Using Cellulose Acetate Foils
Authors: Graupner Nina , Müssig Jörg
Published: February 2024

Bast fibre-reinforced plastics are characterised by good strength and stiffness but are often brittle due to the stiff and less ductile fibres. This study uses a biomimetic approach to improve impact strength. Based on the structure of the spicules of a deep-sea glass sponge, in which hard layers of bioglass alternate with soft layers of proteins, the toughness of kenaf/epoxy composites was significantly improved by a multilayer structure of kenaf and cellulose acetate (CA) foils as impact modifiers. Due to the alternating structure, cracks are deflected, and toughness is improved. One to five CA foils were stacked with kenaf layers and processed to composite plates with bio-based epoxy resin by compression moulding. Results have shown a significant improvement in toughness using CA foils due to increased crack propagation. The unnotched Charpy impact strength increased from 9.0 kJ/m2 of the pure kenaf/epoxy composite to 36.3 kJ/m2 for the sample containing five CA foils. The tensile and flexural strength ranged from 74 to 81 MPa and 112 to 125 MPa, respectively. The tensile modulus reached values between 9100 and 10,600 MPa, and the flexural modulus ranged between 7200 and 8100 MPa. The results demonstrate the successful implementation of an abstract transfer of biological role models to improve the toughness of brittle bast fibre-reinforced plastics.
An Empirical Investigation into the Impact of Social Media Fitness Videos on Users’ Exercise Intentions
Authors: Yin He , Huang Xin , Zhou Guangming
Published: February 2024

Social media fitness influencers are driving the maturation of online fitness, which is especially significant in the current era of globally decreasing levels of physical activity. However, there is a paucity of research on online fitness videos, and the mechanism of influence of fitness videos on exercise intention is not well understood. Therefore, based on the stimulus–organism–response (S-O-R) theoretical framework, this study extends the source credibility theory to the field of fitness and adds an examination of the content quality and electronic word-of-mouth of fitness videos to explore how fitness videos motivate users to participate in physical exercise. Through an online survey, 367 valid samples were collected and validated using a structural equation model. The results showed that the three elements contained in source credibility theory have inconsistent importance in the fitness field, with trustworthiness being the most important, followed by attractiveness, and the influence of expertise is not significant. In summary, the attributes of social media fitness influencers, including trustworthiness and physical attractiveness, as well as the content quality and electronic word-of-mouth of their fitness videos, may lead to viewers’ trust and perception of the usefulness of the videos and, furthermore, lead to exercise intention.
The Influence of Excitation Method on the Strength of Glass Powder High-Strength Cementitious Materials
Authors: Li Bixiong , Wei Xin , Zhang Zhibo , Peng Bo
Published: February 2024

Recycling economy and the re-utilization of solid waste have become important parts of sustainable development strategy. To improve the utilization rate of waste glass, glass powder high-strength cementitious material (GHSC) was prepared by replacing part of the cement in the cementitious material with ground waste glass powder. Firstly, the effect of glass powder particle size on the flexural and compressive strength of GHSC was investigated by the gray correlation method, and the optimal grinding time was obtained. Additionally, the effect of the magnitude of steam curing temperature and the length of steam curing time on the compressive strength and flexural strength of GHSC was investigated, and the mechanism of the effect of the curing regime on the strength was explored by examination of the microstructure. Finally, to simplify the curing process of GHSC, the effects of Ca(OH)2 and Na2SO4 as excitation agents on the compressive strength and flexural strength of GHSC at different dosing levels were compared. The results showed that glass powder with a particle size of less than 20 μm would improve the compressive strength and flexural strength of the specimen. Steam curing can significantly improve the flexural strength and compressive strength of GHSC specimens. At a steam curing temperature of 90 °C for a duration of three days, the compressive strength and flexural strength of GHSC increased by 76.7% and 98.2%, respectively, compared with the standard curing specimens. Ca(OH)2 and Na2SO4 as excitation agents significantly enhanced the compressive and flexural strengths of GHSC under standard curing conditions.
Biological Markers of High-Risk Childhood Acute Lymphoblastic Leukemia
Authors: He Jiasen , Munir Faryal , Catueno Samanta , Connors Jeremy S. , Gibson Amber , Robusto Lindsay , McCall David , Nunez Cesar , Roth Michael , Tewari Priti , Garces Sofia , Cuglievan Branko , Garcia Miriam B.
Published: February 2024

Childhood acute lymphoblastic leukemia (ALL) has witnessed substantial improvements in prognosis; however, a subset of patients classified as high-risk continues to face higher rates of relapse and increased mortality. While the National Cancer Institute (NCI) criteria have traditionally guided risk stratification based on initial clinical information, recent advances highlight the pivotal role of biological markers in shaping the prognosis of childhood ALL. This review delves into the emerging understanding of high-risk childhood ALL, focusing on molecular, cytogenetic, and immunophenotypic markers. These markers not only contribute to unraveling the underlying mechanisms of the disease, but also shed light on specific clinical patterns that dictate prognosis. The paradigm shift in treatment strategies, exemplified by the success of tyrosine kinase inhibitors in Philadelphia chromosome-positive leukemia, underscores the importance of recognizing and targeting precise risk factors. Through a comprehensive exploration of high-risk childhood ALL characteristics, this review aims to enhance our comprehension of the disease, offering insights into its molecular landscape and clinical intricacies in the hope of contributing to future targeted and tailored therapies.
Current Status of Treatment among Patients with Appendiceal Tumors—Old Challenges and New Solutions?
Authors: Chawrylak Katarzyna , Leśniewska Magdalena , Mielniczek Katarzyna , Sędłak Katarzyna , Pelc Zuzanna , Kobiałka Sebastian , Pawlik Timothy M. , Polkowski Wojciech P. , Rawicz-Pruszyński Karol
Published: February 2024

The 5th edition of the World Health Organization (WHO) classification of tumors of the digestive system distinguishes four categories of appendiceal tumors (ATs): serrated lesions and polyps, mucinous neoplasms, adenocarcinomas, and neuroendocrine neoplasms (NENs). The differential diagnosis of ATs can be challenging in medical practice, due to their rarity and lack of data from randomized controlled trials on a large, diverse group of patients. ATs are usually noted in specimens obtained during appendectomies due to clinical acute appendicitis. In the European population, most ATs (65%) occur over the age of 50 and among women (56.8%). According to histological type, 54.6% are neuroendocrine tumors (NETs); 26.8% cystic, mucinous, and serous neoplasms; and 18.6% adenocarcinoma not otherwise specified (NOS). On pathologic analysis, most AT findings are benign lesions or small NENs that do not require further therapeutic measures. The presence of appendiceal mucinous neoplasm (AMN) can lead to pseudomyxoma peritonei (PMP). While the multimodal treatment for abdominal malignancies has evolved over the past several decades, the clinical workup and treatment of ATs remain a challenge. Therefore, this review aims to describe the diagnostic possibilities, molecular-based diagnosis, staging, differences in the treatment process, and prognostic factors associated with ATs.
Stereoselective Catalytic Synthesis of Bioactive Compounds in Natural Deep Eutectic Solvents (NADESs): A Survey across the Catalytic Spectrum
Authors: Carreiro Elisabete P. , Federsel Hans-Jürgen , Hermann Gesine J. , Burke Anthony J.
Published: February 2024

Deep eutectic solvents (DESs) are a mixture of two or more components, and at a particular composition, they become liquids at room temperature. When the compounds that constitute the DESs are primary metabolites namely, amino acids, organic acids, sugars, or choline derivatives, the DESs are called natural deep eutectic solvents (NADESs). NADESs fully represent green chemistry principles. These solvents are highly welcome, as they are obtained from renewable resources, and gratifyingly are biodegradable and biocompatible. They are an alternative to room-temperature ionic liquids (RTILs). From the pharmaceutical industry’s point of view, they are highly desirable, but they unfortunately have been rarely used despite their enormous potential. In this review, we look at their impact on the asymmetric catalytic synthesis of key target molecules via metal-based catalysis, biocatalysis, and organocatalysis. In many cases, the NADESs that have been used are chiral and can even promote enantioselective reactions; this crucial and very exciting aspect is also discussed and analyzed.
Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes
Authors: Papaccio Federica , Caputo Silvia , Iorio Alessandra , De Simone Paola , Ottaviani Monica , Del Brocco Antonella , Frascione Pasquale , Bellei Barbara
Published: February 2024

Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major clinical risk factors for melanoma include fair skin, an increased number of nevi, the presence of dysplastic nevi, and a family history of melanoma. However, several external inducers seem to be associated with melanoma susceptibility such as environmental exposure, primarily unprotected sun experience, alcohol consumption, and heavy metals. In recent years, epidemiological studies have highlighted a potential risk of β-hexachlorocyclohexane (β-HCH), the most studied organochlorine pesticide, causing cancer induction including melanoma. Methods: We evaluated in vitro the impact of this pollutant on epidermal and dermal cells, attempting to describe mechanisms that could render cutaneous cells more prone to oncogenic transformation. Results: We demonstrated that β-HCH impacts melanocyte biology with a highly cell-type specific signature that involves perturbation of AKT/mTOR and Wnt/β-catenin signaling, and AMPK activation, resulting in lowering energy reserve, cell proliferation, and pigment production. Conclusions: In conclusion, long-term exposure to persistent organic pollutants damages melanocyte metabolism in its function of melanin production with a consequent reduction of melanogenesis indicating a potential augmented skin cancer risk.
Mechanobiology of Dental Pulp Cells
Authors: Bryniarska-Kubiak Natalia , Basta-Kaim Agnieszka , Kubiak Andrzej
Published: February 2024

The dental pulp is the inner part of the tooth responsible for properly functioning during its lifespan. Apart from the very big biological heterogeneity of dental cells, tooth microenvironments differ a lot in the context of mechanical properties—ranging from 5.5 kPa for dental pulp to around 100 GPa for dentin and enamel. This physical heterogeneity and complexity plays a key role in tooth physiology and in turn, is a great target for a variety of therapeutic approaches. First of all, physical mechanisms are crucial for the pain propagation process from the tooth surface to the nerves inside the dental pulp. On the other hand, the modulation of the physical environment affects the functioning of dental pulp cells and thus is important for regenerative medicine. In the present review, we describe the physiological significance of biomechanical processes in the physiology and pathology of dental pulp. Moreover, we couple those phenomena with recent advances in the fields of bioengineering and pharmacology aiming to control the functioning of dental pulp cells, reduce pain, and enhance the differentiation of dental cells into desired lineages. The reviewed literature shows great progress in the topic of bioengineering of dental pulp—although mainly in vitro. Apart from a few positions, it leaves a gap for necessary filling with studies providing the mechanisms of the mechanical control of dental pulp functioning in vivo.
Gas and Liquid Chromatography Mass Spectrometry as a Tool for Elucidating Volatile Organic Compounds (VOCs) and Metabolites in Maternal Milk: A Perspective on Infants’ Health Risk Assessment
Authors: Tzanetou Evangelia N. , Manea-Karga Electra , Baira Eirini , Boutsikou Theodora , Iliodromiti Zoi , Iacovidou Nicoletta , Machera Kyriaki , Kasiotis Konstantinos M.
Published: February 2024

Maternal milk is pivotal for infants’ nutrition. It also portrays the chemical burden to which the mother has been exposed. One of the chemical families that is prevalent and related to potential toxic effects are volatile organic compounds (VOCs). In the present study, motivated by the scarcity of works dealing with concomitant VOC and metabolite determination in maternal milk, two new gas/liquid chromatography tandem mass spectrometry (GC-MS/MS, LC-MS/MS) methods for the simultaneous measurement of 25 VOCs and 9 of their metabolites, respectively, in maternal milk were developed and applied to 20 maternal milk samples collected from mothers in Greece. In parallel, a headspace solid-phase microextraction (HS-SPME)–GC-MS method was employed for the untargeted screening of chemicals. Low detection rates for benzene, toluene, styrene and p,m-xylenes, and three of their metabolites, namely N-acetyl-S-(benzyl)-L-cysteine (BMA, metabolite of toluene), 3-methylhippuric (3-MHA, metabolite of xylenes) and mandelic acid (MA as DL and R isomers, metabolites of styrene and ethylbenzene), were evidenced in concentrations varying from <lower limit of quantification (LLOQ) to 0.79 ng mL−1. HS-SPME–GC-MS disclosed the presence of common maternal milk constituents such as fatty acids. Nevertheless, bisphenol-A, bisphenol derivatives and phthalates were also detected. The infants’ health risk assessment demonstrated a low risk and negligible carcinogenic risk, yet the detection of these compounds should not be underestimated.
Experience of an Italian Pediatric Third Level Emergency Department during the 2022–2023 Bronchiolitis Epidemic: A Focus on Discharged Patients and Revisits
Authors: Iudica Giovanna , Franzone Daniele , Ferretti Marta , Tubino Barbara , Santaniello Stefania , Brisca Giacomo , Formigoni Clelia , Data Erica , Piccotti Emanuela
Published: February 2024

The aim of this study was to describe the 2022–2023 bronchiolitis epidemic season (the second after COVID-19 pandemic and the first without social restriction), focusing on patients discharged home from a pediatric emergency department (PED) and on those revisited within 72 h. We performed a retrospective observational study in an Italian tertiary care children’s hospital, reviewing PED accesses from 1 October 2022 to 31 March 2023. The number of hospitalizations for bronchiolitis was extracted from hospital discharge forms. A total of 512 patients diagnosed with bronchiolitis were admitted to PED (2.8% of total admissions). Accesses increased sharply from November to January, with a peak in December, in both admissions and hospitalizations. More than half of the patients (55.5%) were safely discharged home, while 38 (13.4%) came back to PED for a revisit. Overall PED accesses and hospitalizations for bronchiolitis increased since the previous epidemic season, and particularly compared to the pandemic and pre-pandemic eras. Empowering the collaboration between all healthcare provisioners is fundamental to suitable management of patients. Monitoring the epidemiology and seasonality of bronchiolitis is a starting point for an effective internal organization of pediatric departments and to further evaluate its socio-economic burden.
Prenatal Alcohol Exposure and Metabolic Disorders in Pediatrics: The Role of the Oxidative Stress—A Review of the Literature
Authors: Derme Martina , Briante Martina , Ceccanti Mauro , Giannini Giuseppe , Vitali Mario , Messina Marisa Patrizia , Piccioni Maria Grazia , Mattia Alessandro , Nicotera Simona , Crognale Alba
Published: February 2024

Prenatal alcohol exposure is responsible for increasing chronic disease risk in later life, including obesity and metabolic syndrome. Alcohol drinking may compromise endogenous antioxidant capacity, causing an increase in free radicals and reactive oxygen species in the newborn. Excessive reactive oxygen species could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction. Moreover, oxidative stress could play a crucial role in the altered synthesis and release of neurotrophins and progressive mitochondrial modifications with uncontrolled apoptosis. This narrative review aims to underline the important role of alcohol abuse in oxidative stress events and consequent metabolic and neurocognitive impairments in children exposed to alcohol during gestational life.
Timely Surgical Intervention Leads to Better Sustained Coverage after Reconstructive Hip Surgery in Patients with Cerebral Palsy
Authors: van Stralen Renée Anne , Kempink Dagmar Raymond Jacques , Titulaer Alexandra Frederika , Eygendaal Denise , Reijman Max , Tolk Jaap Johannes
Published: February 2024

Background: In up to 45–90% of non-ambulatory patients with cerebral palsy (CP), progressive hip migration can be observed. The goal of this study was to determine whether the implementation of a national hip surveillance guideline affected the outcome of hip reconstructions. Methods: We reviewed 48 primary hip reconstructions at a median follow-up of 4.4 years. Surgical outcome was evaluated based on complication rates and radiographic evaluation postoperatively and at follow-up. Radiographic measurements included the migration percentage (MP), head–shaft angle and acetabular index. The impact of preoperative MP, postoperative MP, tone management, Gross Motor Function Classification System (GMFCS) classification and age on MP at follow-up were examined using a mixed model analysis. Results: A decrease in preoperative MP was noted, from a median of 75.0% (2014) to 39.0% (2020). Lower preoperative MP showed a significant correlation to lower MP postoperatively (p = 0.012). Postoperative MP was a significant independent predictor of a lower MP at follow-up (p = 0.002). Conclusions: This study shows an improvement in the timing of hip reconstruction in patients with CP after implementation of the hip surveillance guideline. A reduction in preoperative MP resulted in improved postoperative outcomes. A lower postoperative MP was the most important predictor for sustained containment of the hip.
The Role of Aminopeptidase ERAP1 in Human Pathology—A Review
Authors: Țiburcă Laura , Zaha Dana Carmen , Jurca Maria Claudia , Severin Emilia , Jurca Aurora , Jurca Alexandru Daniel
Published: February 2024

Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic reticulum aminopeptidase 2), and LNPEP (coding for leucyl and cystinyl aminopeptidase). These genes encoding these enzymes are contiguous and located on the same chromosome (5q21); they share structural homology and functions and are associated with immune-mediated diseases. These aminopeptidases play a key role in immune pathology by cleaving peptides to optimal sizes for binding to the major histocompatibility complex (MHC) and contribute to cellular homeostasis. By their ability to remove the extracellular region of interleukin 2 and 6 receptors (IL2, IL6) and the tumor necrosis factor receptor (TNF), ERAP1 and ERAP2 are involved in regulating the innate immune response and, finally, in blood pressure control and angiogenesis. The combination of specific genetic variations in these genes has been linked to various conditions, including autoimmune and autoinflammatory diseases and cancer, as well as hematological and dermatological disorders. This literature review aims to primarily explore the impact of ERAP1 polymorphisms on its enzymatic activity and function. Through a systematic examination of the available literature, this review seeks to provide valuable insights into the role of ERAP1 in the pathogenesis of various diseases and its potential implications for targeted therapeutic interventions. Through an exploration of the complex interplay between ERAP1 and various disease states, this review contributes to the synthesis of current biomedical research findings and their implications for personalized medicine.
Experimental Investigation of Mechanical Properties of Concrete Mix with Lightweight Expanded Polystyrene and Steel Fibers
Authors: Shah Syed Jahanzaib , Naeem Asad , Hejazi Farzad , Mahar Waqas Ahmed , Haseeb Abdul
Published: February 2024

The demand for lightweight aggregates in concrete compositions for diverse structural and non-structural applications in contemporary building construction has increased. This is to achieve a controllable low-density lightweight concrete, which reduces the overall structural weight. However, the challenge lies in achieving an appropriate strength in lightweight concrete while maintaining a lower unit weight. This research aims to evaluate the performance of lightweight concrete by integrating expanded polystyrene (EPS) as a partial replacement for coarse aggregate. Test specimens were cast by blending EPS with coarse aggregate at varying proportions of 0%, 15%, 30%, and 45%, while maintaining a constant water-to-binder ratio of 0.60. To enhance the bonding and structural capabilities of the proposed lightweight concrete mixes, reinforcement with 2% and 4% steel fibers by volume of the total concrete mix was incorporated. Silica fume was introduced into the mix to counteract the water hydrophobicity of EPS material and enhance the durability of lightweight concrete, added at a rate of 10% by weight of cement in all specimens. A total of 60 samples, including cylinders and beams, were prepared and cured over 28 days. The physical and mechanical properties of the lightweight EPS-based concrete were systematically examined through experimental testing and compared against a standard concrete mix. The analysis of the results indicates that EPS-based concrete exhibits a controllable low density. It also reveals that incorporating reinforcement materials, such as steel fibers, enhances the overall strength of lightweight concrete.
Application of Photovoltaic and Solar Thermal Technologies in Buildings: A Mini-Review
Authors: Xiao Hua , Lai Wenjin , Chen Aiguo , Lai Shini , He Wenjing , Deng Xi , Zhang Chao , Ren Hongyun
Published: February 2024

Buildings account for a significant proportion of total energy consumption. The integration of renewable energy sources is essential to reducing energy demand and achieve sustainable building design. The use of solar energy has great potential for promoting energy efficiency and reducing the environmental impact of energy consumption in buildings. This study examines the applications of photovoltaic and solar thermal technologies in the field of architecture, demonstrating the huge potential of solar energy in building applications. To ensure a fresh and thorough review, we examine literature that encompasses the advancements made in the utilization of solar energy in buildings over the past decade. The key factors to consider in this study are reliability, performance, cost and aesthetics in real applications of photovoltaic and solar thermal technologies in the field of architecture, which have a significant impact on people’s acceptance of solar energy technology. Recent developments in feasible and effective optimization solutions for solar energy technologies are summarized. Accurate and convenient simulation techniques are also summarized for reference. The results show that the rapid progress of BIPV systems is fueled by advancements in three crucial areas: enhancing solar cell and module efficiency, reducing manufacturing costs and achieving a competitive levelized cost of electricity. The results can provide researchers with a reference for understanding recent technological developments in the integration of solar energy into buildings.
Correction: Ferruggia et al. Effectiveness of a Novel Compound HAIR & SCALP COMPLEX on Hair Follicle Regeneration. Cosmetics 2024, 11, 10
Authors: Ferruggia Greta , Contino Martina , Zimbone Massimo , Brundo Maria Violetta
Published: February 2024

In the original publication [...]
Economic Development in the Digital Economy: A Bibliometric Review
Authors: Al-Zoubi Waleed Kalf
Published: February 2024

This study aims to investigate economic development in the digital economy and uncover trends and insights that might contribute to future research. Furthermore, the study, examining English-language publications from 2000 to 2023 in the Web of Science Core Collection, employs bibliometric and content analysis to statistically evaluate the field of economic development in the digital economy. Co-citation, co-authorship, and bibliographical coupling analyses revealed China, the Chinese Academy of Sciences (CAS), and “Sustainability” as the leading influencers in terms of country, institution, and journal, respectively. Five key themes emerged: (1) the interplay between digital technologies and economic growth, (2) leveraging digital tools for businesses, (3) the applications and impacts of diverse digital technologies across sectors, (4) the broader social implications of the digital economy, and (5) government policies for fostering digital economic progress. The study concludes by proposing avenues for further investigation.
Quantum Science and Technologies in K-12: Supporting Teachers to Integrate Quantum in STEM Classrooms
Authors: Holincheck Nancy , Rosenberg Jessica L. , Zhang Xiaolu , Butler Tiffany N. , Colandene Michele , Dreyfus Benjamin W.
Published: February 2024

Quantum science and computing represent a vital intersection between science and technology, gaining increasing importance in modern society. There is a pressing need to incorporate these concepts into the K-12 curriculum, equipping new generations with the tools to navigate and thrive in an evolving technological landscape. This study explores the professional learning of K-12 teachers (n = 49) related to quantum concepts and pedagogy. We used open-ended surveys, field notes, workshop artifacts, and interviews to examine teachers’ perceptions of quantum and how they made connections between quantum and their curriculum. Our data reveal that most teachers were excited and interested in teaching quantum but were aware of potential barriers and concerns that might get in the way of teaching quantum. We found that teachers readily identified connections to math and science in their curriculum, but only a few made connections to computing. Enthusiasm for teaching quantum concepts was found in both elementary and secondary educators, suggesting a widespread recognition of its importance in preparing students for a future where quantum technology is a fundamental aspect of their lives and careers.
Associations of Mental Health Issues with Health Literacy and Vaccination Readiness against COVID-19 in Long-Term Care Facilities—A Cross-Sectional Analysis
Authors: Sanftenberg Linda , Gschwendner Maresa , Grass Andreas , Rottenkolber Marietta , Zöllinger Isabel , Sebastiao Maria , Kühlein Thomas , Hindenburg Dagmar , Gágyor Ildikó , Wildgruber Domenika , Hausen Anita , Janke Christian , Hoelscher Michael , Teupser Daniel , Dreischulte Tobias , Gensichen Jochen ,   on behalf of the BACOM Study Group
Published: February 2024

Vaccinations against COVID-19 are of the utmost importance in long-term care facilities. During the pandemic, mental health issues increased significantly. This cross-sectional analysis aimed to assess the associations of depression and anxiety with health literacy in people in need of care and the association of depression and burnout with vaccination readiness against COVID-19 in health care workers (HCWs). Within our cross-sectional study, people in need of care were assessed for symptoms of depression (PHQ-9), anxiety (GAD-7), and health literacy (HLS-EU-Q16). Among HCWs, we assessed symptoms of depression (PHQ-9) and burnout (MBI-HSS), as well as psychological antecedents of vaccination (5C) to measure vaccination readiness against COVID-19. A multivariate regression analysis was performed. Symptoms of a major depression were significantly associated with reduced health literacy (p = 0.010) in people in need of care. Among HCWs, symptoms of depression and burnout reduced vaccination readiness against COVID-19 significantly. In particular, collective responsibility was reduced in HCWs suffering from burnout symptoms (p = 0.001). People in need of care and their HCWs could benefit from intensified target group-specific vaccination counseling. Additionally, more attention should be paid to the protection of mental health in long-term care facilities.
Bridging the Cybersecurity Gap: A Comprehensive Analysis of Threats to Power Systems, Water Storage, and Gas Network Industrial Control and Automation Systems
Authors: Gueye Thierno , Iqbal Asif , Wang Yanen , Mushtaq Ray Tahir , Petra Mohd Iskandar
Published: February 2024

This research addresses the dearth of real-world data required for effective neural network model building, delving into the crucial field of industrial control and automation system (ICS) cybersecurity. Cyberattacks against ICS are first identified and then generated in an effort to raise awareness of vulnerabilities and improve security. This research aims to fill a need in the existing literature by examining the effectiveness of a novel approach to ICS cybersecurity that draws on data from real industrial settings. Real-world data from a variety of commercial sectors is used in this study to produce a complete dataset. These sectors include power systems, freshwater tanks, and gas pipelines, which together provide a wide range of commercial scenarios where anomaly detection and attack classification approaches are critical. The generated data are shown to considerably improve the models’ precision. An amazing 71% accuracy rate is achieved in power system models, and incorporating generated data reliably increases network speed. Using generated data, the machine learning system achieves an impressive 99% accuracy in a number of trials. In addition, the system shows about 90% accuracy in most studies when applied to the setting of gas pipelines. In conclusion, this article stresses the need to improve cybersecurity in vital industrial sectors by addressing the dearth of real-world ICS data. To better understand and defend against cyberattacks on industrial machinery and automation systems, it demonstrates how generative data can improve the precision and dependability of neural network models.
Switchable Heat Pipes for Eco-Friendly Battery Cooling in Electric Vehicles: A Life Cycle Assessment
Authors: Illner Maike , Thüsing Kai , Salles Ana , Trettenhann Anian , Albrecht Stefan , Winkler Markus
Published: February 2024

Battery thermal management systems (BTMSs) ensure that lithium-ion batteries (LIBs) in electric vehicles (EVs) are operated in an optimal temperature range to achieve high performance and reduce risks. A conventional BTMS operates either as an active system that uses forced air, water or immersion cooling, or as a complete passive system without any temperature control. Passive systems function without any active energy supply and are therefore economically and environmentally advantageous. However, today’s passive BTMSs have limited cooling performance, which additionally cannot be controlled. To overcome this issue, an innovative BTMS approach based on heat pipes with an integrated thermal switch, developed by the Fraunhofer Cluster of Excellence Programmable Materials (CPM), is presented in this paper. The suggested BTMS consists of switchable heat pipes which couple a passive fin-based cold plate with the battery cells. In cold state, the battery is insulated. If the switching temperature is reached, the heat pipes start working and conduct the battery heat to the cold plate where it is dissipated. The environmental benefits of this novel BTMS approach were then analysed with a Life Cycle Assessment (LCA). Here, a comparison is made between the suggested passive and an active BTMS. For the passive system, significantly lower environmental impacts were observed in nearly all impact categories assessed. It was identified as a technically promising and environmentally friendly approach for battery cooling in EVs of the compact class. Furthermore, the results show that passive BTMS in general are superior from an environmental point of view, due their energy self-sufficient nature.
Digitalization, Industry 4.0, Data, KPIs, Modelization and Forecast for Energy Production in Hydroelectric Power Plants: A Review
Authors: Pepe Crescenzo , Zanoli Silvia Maria
Published: February 2024

Intelligent water usage is required in order to target the challenging goals for 2030 and 2050. Hydroelectric power plants represent processes wherein water is exploited as a renewable resource and a source for energy production. Hydroelectric power plants usually include reservoirs, valves, gates, and energy production devices, e.g., turbines. In this context, monitoring and maintenance policies together with control and optimization strategies, at the different levels of the automation hierarchy, may represent strategic tools and drivers for energy efficiency improvement. Nowadays, these strategies rely on different basic concepts and elements, which must be assessed and investigated in order to provide a reliable background. This paper focuses on a review of the state of the art associated with these basic concepts and elements, i.e., digitalization, Industry 4.0, data, KPIs, modelization, and forecast.