bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance
Authors: El Hassouni Btissame , Sarkisjan Dzjemma , Vos J. Chris , Giovannetti Elisa , Peters Godefridus J.
Published: December 2018

Background:

Inherent or acquired chemo resistance in cancer patients has been a perpetual
limitation in cancer treatment. Expanding knowledge on essential cellular processes opens a new
window for therapeutic targeting. Ribosome biogenesis is a process that shows potential due to its
fundamental role in cell development and contribution to tumorigenesis as a result of its upregulation.
Inhibiting components of ribosome biogenesis has been explored and has shown interesting
results. Yet, an important key component, methyltransferase Fibrillarin (FBL), which influences
both the abundance and composition of ribosomes, has not been exploited thus far.

Methods:

In this literature review, we describe relevant aspects of ribosome biogenesis in cancer to
emphasize the potential of FBL as a therapeutic target, in order to lower the genotoxic effects of
anti-cancer treatment.

Results:

Remarkably, the amplification of the 19q13 cytogenetic band, including the gene coding
for FBL, correlated to cell viability and resistance in pancreatic cells as well as to a trend toward a
shorter survival in pancreatic cancer patients.

:

Targeting ribosome biogenesis, more specifically compared to the secondary effects of chemotherapeutics
such as 5-fluorouracil or oxaliplatin, has been achieved by compound CX-5461. The cell
dependent activity of this Pol I inhibitor has been reported in ovarian cancer, melanoma and leukemia
models with active or mutated p53 status, presenting a promising mechanism to evade p53 resistance.

Conclusion:

Targeting critical ribosome biogenesis components in order to decrease the genotoxic
activity in cancer cell looks promising. Hence, we believe that targeting key protein rRNA methyltransferase
FBL shows great potential, due to its pivotal role in ribosome biogenesis, its correlation
to an improved survival rate at low expression in breast cancer patients and its association with p53.
Transition Metal-Based Prodrugs for Anticancer Drug Delivery
Authors: Phillips Ana M.F. , Pombeiro Armando J.L.
Published: December 2018

:

Transition metal complexes, of which the platinum(II) complex cisplatin is an example, have been used in medicine to treat cancer for more than 40 years. Although many successes have been achieved, there are problems associated with the use of these drugs, such as side effects and drug resistance. Converting them into prodrugs, to make them more inert, so that they can travel to the tumour site unchanged and release the drug in its active form only there, is a strategy which is the subject of much research nowadays. The new prodrugs may be activated and release the cytotoxic agent by differences in oxygen concentration or in pH, by the action of overexpressed enzymes, by differences in metabolic rates, etc., which characteristically distinguish cancer cells from normal ones, or even by the input of radiation, which can be visible light. Converting a metal complex into a prodrug may also be used to improve its pharmacological properties. In some cases, the metal complex is a carrier which transports the active drug as a ligand. Some platinum prodrugs have reached clinical trials. So far platinum, ruthenium and cobalt have been the most studied metals. This review presents the recent developments in this area, including the types of complexes used, the mechanisms of drug action and in some cases the techniques applied to monitor drug delivery to cells.
Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents
Authors: Kołakowska Urszula , Kuroczycka-Saniutycz Elżbieta , Olański Witold , Wasilewska Anna
Published: December 2018

Purpose:

The emerging evidence has recently shown an evident dependence between recently identified
salusin peptides and atherosclerosis, and their important roles as endogenous modulators of atherogenesis. It
was reported that the development of atherosclerosis could also be affected by endogenous salusin-
β overproduction in vascular lesions.

Materials/Methods:

This prospective cohort study was conducted in two groups of children: HT – 58 patients
with essential hypertension (HT); R - 30 participants with white-coat HT (R). We analysed the relationship between
serum salusin- α and salusin- β levels and ADMA, SDMA and hs- CRP in children and adolescents with
essential hypertension.

Results:

Serum level of salusin- ɑ in each sample was under the sensitivity of method. Serum level of salusin-β
was statistically significantly higher in hypertension group when compared to the reference group (p<0.05) and
correlated positively with serum hs-CRP [rho=0.47; p<0.01] and asymmetric dimethylarginine (ADMA)
[rho=0.32; p<0.05]. There was no significant association between salusin-β and symmetric dimethylarginine
(SDMA) [rho=0.27; p>0.05].

Conclusion:

This preliminary study showed that the concentration of salusin-β is associated with circulating level
of hs-CRP and ADMA in teenagers with hypertension. Further studies are needed to find out if salusin-β levels
may indicate for endothelial dysfunction and form the basis for the development of new therapeutic agent.
HOXA4-Dependent Transcriptional Activation of AXL Promotes Cisplatin- Resistance in Lung Adenocarcinoma Cells
Authors: Yu Shuo , Ren Hui , Li Yang , Liang Xuan , Ning Qian , Chen Xue , Chen Mingwei , Hu Tinghua
Published: December 2018

Background:

Lung cancer is one of the most leading causes of cancer-related deaths in adults worldwide.
Non-Small Cell Lung Cancer (NSCLC), which comprises 80 to 85% of all lung cancers, is the most lethal subtype of
lung cancer with a 5-year survival of less than 13%. In this study, we identified a poorly-studied kinase PDK4 as the
most up-regulated kinase encoding gene in Cisplatin resistant lung adenocarcinoma.

Methods:

In vitro cell viability assay and in vivo tumor xenograft assay were used in the detection of cell proliferation.
RNA isolation, quantitative Real-Time PCR, Western blot analysis, immunohistochemistry were used to investigate
the expression of RNA and protein. Lentivirus infection was used to regulate gene expression. Luciferase assays
were used to monitor EPAS1 promoter activity.

Results:

In vivo PDK4 expression was elevated in a Cisplatin-resistant population of lung adenocarcinoma cells,
PDK4-dependent Cisplatin-resistance promotes tumor growth of lung adenocarcinoma in vivo and in vitro, clinically
PDK4 expression was associated with poor prognosis in lung adenocarcinoma patients, mechanically PDK4 promoted
cell growth and Cisplatin-resistance of lung adenocarcinoma via transcriptional regulation of endothelial PAS
domain-containing protein 1 (EPAS1).

Conclusion:

PDK4 is the most up-regulated kinase encoding gene in Cisplatin resistant lung adenocarcinoma and
PDK4-dependent Cisplatin-resistance promotes tumor growth of lung adenocarcinoma mainly through transcriptional
regulation of EPAS1. Enriched PDK4 expression was correlated with the poor prognosis of lung cancer patients,
indicating that PDK4 could be a potential therapeutic target for Cisplatin-resistant lung adenocarcinoma.
Hubungan kemampuan manajerial kepala satuan PAUD dan self-efficacy guru dengan kinerja guru di Kecamatan Bukit Kerman kaBupaten Kerinci Propinsi Jambi
Authors: Amanda Rizki Amanda , Suryono Yoyon
Published: December 2018

Penelitian ini bertujuan untuk mengukur hubungan kemampuan manajerial kepala satuan PAUD dan self-efficacy guru dengan kinerja guru PAUD. Penelitian ini merupakan penelitian korelasional dengan pendekatan kuantitatif. Sampel penelitian adalah seluruh guru PAUD non-formal yang ada di Kecamatan Bukit Kerman yang  berjumlah 59 guru. Teknik sampling yang digunakan adalah sampling jenuh dimana populasi dijadikan sampel. Data dikumpulkan menggunakan angket yang telah divalidasi oleh ahli dan selanjutnya di uji validitas dan reliabilitasnya. Data dianalisis menggunakan statistik deskriptif, regresi linear sederhana dan regresi linier ganda. Hasil pengujian menunjukkan bahwa (1) terdapat hubungan yang signifikan antara kemampuan manajerial satuan PAUD dengan kinerja guru, (2) terdapat hubungan yang signifikan antara self-efficacy dengan kinerja guru, (3) terdapat hubungan yang signifikan antara kemampuan manajerial kepala satuan PAUD dan self-efficacy guru secara simultan terhadap kinerja guru.Kata Kunci: Kemampuan manajerial, self-efficacy, kinerja guru THE RELATIONSHIP BETWEEN THE PRINCIPAL’S MANAGERIAL ABILITY AND TEACHER SELF-EFFICACY ON TEACHER’S PERFORMANCE OF EARLY CHILDHOOD EDUCATION IN BUKIT KERMAN DISTRICT KERINCI REGENCYAbstractThis study aims to determine the relationship between the managerial ability of the principal of early childhood education and teacher self-efficacy and teacher’s performance. This study uses a quantitative approach. The sample of the research was all non-formal early childhood teachers in Bukit Kerman district, which amounted to 59 teachers. The sampling technique used was saturated sampling where the population was sampled. Data were collected using questionnaires that have been validated by experts and subsequently tested for validity and reliability. Data were analyzed using descriptive statistics, simple linear regression and multiple linear regression and coefficient of determination calculation. The result of the test shows that: (1) there is a significant relationship between the managerial ability of principal of early childhood education and teacher’s performance, (2) there is a significant relationship between self-efficacy with teacher’s performance, and (3) there is a significant relationship between managerial ability of principal of early childhood education and teacher self-efficacy simultaneously on teacher performanceKeywords: Managerial ability, self-efficacy, teacher performance
Lesson study in competence development of accounting teachers
Authors: Hasan Imam , Martono Trisno , Susilaningsih Susilaningsih
Published: December 2018

This research aimed to find out and explore the lesson study practice in developing the accounting teacher’s professionalism. This research employed qualitative research using a single instrumental case-study strategy. The data were collected using in-depth interview, observation, and documentation. Then, they were analysed using interactive model. The results of the research showed that with the implementation of the lesson study in schools, it succeeded in improving the four teachers’ competencies. The improvement of the pedagogical competence can be seen from the well preparation of learning, the selection of teaching strategies according to the characteristics of the students and the implementation of memorable learning for the students. Professional competence can also be seen from the teacher's preparation in choosing relevant and up-to-date materials, teaching them by connecting to daily practice and always evaluating the material taught to maintain the quality of the material. The improvement of the social competence can be seen from the more effective communication between the teachers and students and their colleagues. The improvement of the personality competence is indicated by the teachers’ attitudes that are increasingly wise and prestigious in responding to the conditions related to their work. The research implication is that the practice of lesson study can form accounting teacher learning groups that serve as a place for sharing and discussion in developing their professionalism.
An evaluation of students industrial training courses implementation at higher education
Authors: Ambiyar Ambiyar , Yulastri Asmar , Putri Yuzia Eka , Wulansari Rizky Ema
Published: December 2018

This article aims to reveal the factual basis regarding the implementation of Students Industrial Training (SIT) course by the bachelor’s degree students of Hospitality Management Department from the Faculty of Tourism and Hospitality at the University. The methodology used in this study is mixed method with CSE-UCLA evaluation model. The informants in this study were 35 hospitality management students who were graduated in 2015, the SIT Coordinators, Heads of Tourism Departments, and Supervisors, Managers, Industrial Supervisors, senior staffs, and assistance from the Hotel Food and Beverage department. Data of this research were gathered through observation, questionnaires, and interviews. Those data were analyzed by using descriptive statistics technique. The results showed the average score of the need assessment evaluation component was 4.2 (good), program planning was 4.14 (good), formative evaluation was 4.04 (good), and summative evaluation was 3.98 (enough). This Students Industrial Training Program can be continued by improving the students’ knowledge, working skills, and English skills, as well as improving the role of supervisors and instructors/ industrial supervisors in monitoring and providing solutions for the students to overcome problems they faced. Furthermore, this training program needed to improve the quality and quantity of relevant campus facilities and infrastructure to the hospitality industry, and increasing the positive attitude of the students in carrying out the industrial training course.
AMERİKAN CEVİZ, AMERİKAN MEŞESİ VE KIRMIZI AMERİKAN MEŞESİ ODUNLARINDA RENK VE PARLAKLIK ÜZERİNE ISIL İŞLEMİN (THERMOWOOD METOT) ETKİSİ
Authors: AYATA Ümit , ÇAVUŞ Vedat
Published: December 2018

Bu
çalışmada, ThermoWood yöntemine göre ısıl işlem görmüş ve görmemiş Amerikan ceviz (Juglans nigra), Amerikan meşesi (Quercus alba) ve kırmızı Amerikan meşesi (Quercus rubra) ağaç
türlerine ait ahşap örnekler üzerinde renk ve parlaklık değerlerinin tespit edilmesi amaçlanmıştır. Bu amaç
ile 212°C’de 1 saat ve 2 saat süreyle ısıl işlem görmüş ve ısıl işlem görmemiş ağaç
türlerinde renk parametreleri ile 20°, 60°, 85°’de yüzeye dik ve paralel
parlaklık değerleri tespit edilmiştir. Araştırma sonuçlarına göre bütün ağaç türlerinde
toplam renk farkı (ΔE*) değerleri
birbirlerine çok yakın sonuçlar verdiği görülmüştür. Amerikan ceviz, Amerikan
meşesi ve kırmızı Amerikan meşesi ağaç türlerinde uygulanan ısıl işlem süresinin
artması ile L* ve b* değerlerinin azaldığı, toplam renk
farkı (ΔE*) değerlerinin arttığı belirlenmiştir. Amerikan meşesi ağacına
ait deney örneklerinde ısıl işlem sonrasında 20°’de yapılan paralel ve
dik parlaklık değerlerinin ve 60°’de yapılan paralel parlaklık değerlerinin azaldığı
tespit edilmiştir. Uygulanmış olan ısıl işlem sonrasında ahşap malzemeler
üzerinde renk ve parlaklık değerlerinin değiştiği görülmektedir.
WIRELESS SENSOR NETWORK BASED REMOTE DRIP IRRIGATION SYSTEM
Authors: Bingöl Okan , Özkaya Burçin , Bayram Mustafa
Published: December 2018

From past to present, different methods have been used
for agricultural irrigation systems. Among these, drip irrigation system is
more efficient than the others. In drip irrigation system, wireless sensor
network is proposed to provide optimized water supply. On the other hand,
zigbee has been recently used for remote irrigation systems. In irrigation
system, majority of electrical energy is consumed by the pump motors.
Therefore, electricity derived from solar energy is important for the economy
of our country for the evaluation of cultivated land in settlements where there
are no electricity transmission and distribution and far from the city center.
In this study, remote controlled and solar powered based drip irrigation system
with using wireless sensor network is carried out. In the system, there are two
dripping system line and each dripping system line has a sensor and a valve
module. These modules and system are controlled by a main module. Moreover,
energy of these modules are provided by solar panels and they are communicated
with each other via wireless sensor network. The control of the drip irrigation
system is provided by the Android interface. Also, the system can be controlled
manually or automatically with android interface via SMS.
Why Medical Students Choose to Use or Not to Use a Web-Based Electrocardiogram Learning Resource: Mixed Methods Study (Preprint)
Authors: Nilsson Mikael , Fors Uno , Östergren Jan , Bolinder Gunilla , Edelbring Samuel
Published: December 2018

BACKGROUND

Electrocardiogram (ECG) interpretation is a core competence and can make a significant difference to patient outcomes. However, ECG interpretation is a complex skill to learn, and research has showed that students often lack enough competence. Web-based learning has been shown to be effective. However, little is known regarding why and how students use Web-based learning when offered in a blended learning situation.

OBJECTIVE

The aim of this paper was to study students’ use of Web-based ECG learning resources which has not previously been studied in relation to study strategies.

METHODS

A qualitative explanatory design using mixed methods was adopted to explore how medical students reason around their choice to use or not to use a Web-based ECG learning resource. Overall, 15 of 33 undergraduate medical students attending a course in clinical medicine were interviewed. Data on usage of the resource were obtained via the learning management system for all students. At the final examination, all the students answered a questionnaire on study strategies and questions about internet access and estimated their own skills in ECG interpretation. Furthermore, study strategies and use patterns were correlated with results from an ECG Objective Structured Clinical Examination (OSCE) and a written course examination.

RESULTS

In total, 2 themes were central in the students’ reasoning about usage of Web-based ECG: assessment of learning needs and planning according to learning goals. Reasons for using the Web resource were to train in skills, regarding it as a valuable complement to books and lectures. The main reasons for not using the resource were believing they already had good enough skills and a lack of awareness of its availability. Usage data showed that 21 students (63%) used the Web resource. Of these, 11 were minimal users and 10 were major users based on usage activity. Large variations were found in the time spent in different functional parts of the resource. No differences were found between users and nonusers regarding the OSCE score, final examination score, self-estimate of knowledge, or favoring self-regulated learning.

CONCLUSIONS

To use or not to use a Web-based ECG learning resource is largely based on self-regulated learning aspects. Decisions to use such a resource are based on multifactorial aspects such as experiences during clinical rotations, former study experiences, and perceived learning needs. The students’ own judgment of whether there was a need for a Web-based resource to achieve the learning goals and to pass the examination was crucial for their decisions to use it or not. An increased understanding of students’ regulation of learning and awareness of variations in their ECG learning needs can contribute to the improvement of course design for blended learning of ECG contexts for medical students.
Wearable Health Technology and Electronic Health Record Integration: Scoping Review and Future Directions (Preprint)
Authors: Dinh-Le Catherine , Chuang Rachel , Chokshi Sara , Mann Devin
Published: December 2018

BACKGROUND

Due to the adoption of electronic health records (EHRs) and legislation on meaningful use in recent decades, health systems are increasingly interdependent on EHR capabilities, offerings, and innovations to better capture patient data. A novel capability offered by health systems encompasses the integration between EHRs and wearable health technology. Although wearables have the potential to transform patient care, issues such as concerns with patient privacy, system interoperability, and patient data overload pose a challenge to the adoption of wearables by providers.

OBJECTIVE

This study aimed to review the landscape of wearable health technology and data integration to provider EHRs, specifically Epic, because of its prevalence among health systems. The objectives of the study were to (1) identify the current innovations and new directions in the field across start-ups, health systems, and insurance companies and (2) understand the associated challenges to inform future wearable health technology projects at other health organizations.

METHODS

We used a scoping process to survey existing efforts through Epic’s Web-based hub and discussion forum, UserWeb, and on the general Web, PubMed, and Google Scholar. We contacted Epic, because of their position as the largest commercial EHR system, for information on published client work in the integration of patient-collected data. Results from our searches had to meet criteria such as publication date and matching relevant search terms.

RESULTS

Numerous health institutions have started to integrate device data into patient portals. We identified the following 10 start-up organizations that have developed, or are in the process of developing, technology to enhance wearable health technology and enable EHR integration for health systems: Overlap, Royal Philips, Vivify Health, Validic, Doximity Dialer, Xealth, Redox, Conversa, Human API, and Glooko. We reported sample start-up partnerships with a total of 16 health systems in addressing challenges of the meaningful use of device data and streamlining provider workflows. We also found 4 insurance companies that encourage the growth and uptake of wearables through health tracking and incentive programs: Oscar Health, United Healthcare, Humana, and John Hancock.

CONCLUSIONS

The future design and development of digital technology in this space will rely on continued analysis of best practices, pain points, and potential solutions to mitigate existing challenges. Although this study does not provide a full comprehensive catalog of all wearable health technology initiatives, it is representative of trends and implications for the integration of patient data into the EHR. Our work serves as an initial foundation to provide resources on implementation and workflows around wearable health technology for organizations across the health care industry.
Preferences, perceptions and barriers of e-health among Latin American physicians: an Ecuadorian cross-sectional study (Preprint)
Authors: Cherrez-Ojeda Ivan , Vanegas Emanuel , Felix Miguel , Mata Valeria L , Jiménez Fanny M , Sanchez Mabel , Simancas-Racines Daniel , Cherrez Sofia , Gavilanes Antonio WD , Eschrich Johannes , Chedraui Peter
Published: December 2018

BACKGROUND

The rapid growth and development of mobile and wireless technologies provides great potential to improve healthcare around the world, especially in low and middle-income countries. The application of eHealth could provide numerous benefits to healthcare systems, however there are still knowledge gaps, particularly in Latin America.

OBJECTIVE

The aim of the study was to assess the preferences, perceptions, and barriers of mobile technologies among physicians in Latin America.

METHODS

We conducted an anonymous cross-sectional survey study in 640 Ecuadorian physicians. This questionnaire consisted of 13 items about demographic data and preferences, perceptions and barriers for eHealth use by physicians. Chi-square tests for goodness of fit and independence were performed, whilst Phi coefficient was interpreted to assess the strength of associations. Fisher exact test was performed when required.

RESULTS

: More than 90% of physicians reported that they use ICTs to message other physicians and patients (p=.000). While 89.5% individuals use social media to interact with other physicians, only 58.1% use them to interact with patients (p=.000). Finally, almost all physicians reported that they use ICTs to search academic information (p=.000). Moreover, more than 80.0% agree that eHealth may be used to promote health and medical services, search new job opportunities, get involved in research projects and promote teamwork with colleagues. However, 83.6% physicians expressed concerns about privacy and patient confidentiality, while 53.8% stated that they lacked the time to use eHealth resources.

CONCLUSIONS

High usage of eHealth applications was found among Ecuadorian physicians. Additionally, most of younger physicians, with less postgraduate years, and non-specialists had a positive perception toward eHealth technologies. Privacy and patient confidentiality, followed by time management, were the most reported barriers in our study.
The Notijoves Project: Protocol for a Randomized Controlled Trial About New Communication Technologies and Gamification to Promote Partner Notification of Sexually Transmitted Infections Among Young People (Preprint)
Authors: Carnicer-Pont Dolors , Loureiro-Varela Eva , Manresa Josep Mª , Martinez Montse , Avecilla-Palau Àngels , Montero-Pons Laura , Falguera-Puig Gemma
Published: December 2018

BACKGROUND

An increase in sexually transmitted infections (STIs) as well as an increase in the use of new information and communication technologies among young people in Catalonia is the inspiration behind the idea of designing a smartphone app to promote partner notification of STIs.

OBJECTIVE

The main objective of this study is to design a Web-based tool adapted to smartphones for partner notification of STIs among youth who are 16 to 24 years old. Additionally, the objective is to evaluate the Web-based tool’s role in increasing the patient referral partner notification.

METHODS

This is a multicenter randomized controlled trial with a proportional stratification of the sample by center and random allocation of participants to the 3 arms of the study (simple Web-based intervention, game Web-based intervention, and control). This study is being conducted by midwives, gynecologists, and physicians in the sexual and reproductive areas of the primary health care centers.

RESULTS

The primary outcome measure is the number and proportion of partner notifications. Additional outcome measures are the yield of early diagnosis and treatment of those exposed and infected, acceptability, barriers, and preferences for partner notification. Expected results include an increase in the yield of partner notification, early diagnosis and treatment among youth using Web-based interventions compared with those receiving the traditional advice to notify, and a description of sexual networks among those participating in the study.

CONCLUSIONS

The Notijoves is expected to have a sustainable positive impact in the partner notification practice among youth and contribute to increasing the awareness of STI prevention.

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/12896
Understanding the Use and Perceived Impact of a Medical Podcast: Qualitative Study (Preprint)
Authors: Malecki Sarah L , Quinn Kieran L , Zilbert Nathan , Razak Fahad , Ginsburg Shiphra , Verma Amol A , Melvin Lindsay
Published: December 2018

BACKGROUND

Although podcasts are increasingly being produced for medical education, their use and perceived impact in informal educational settings are understudied.

OBJECTIVE

This study aimed to explore how and why physicians and medical learners listen to The Rounds Table (TRT), a medical podcast, as well as to determine the podcast’s perceived impact on learning and practice.

METHODS

Web-based podcast analytics were used to collect TRT usage statistics. A total of 17 medical TRT listeners were then identified and interviewed through purposive and convenience sampling, using a semistructured guide and a thematic analysis, until theoretical sufficiency was achieved.

RESULTS

The following four themes related to podcast listenership were identified: (1) participants thought that TRT increased efficiency, allowing them to multitask, predominantly using mobile listening platforms; (2) participants listened to the podcast for both education and entertainment, or “edutainment”; (3) participants thought that the podcast helped them keep up to date with medical literature; and (4) participants considered TRT to have an indirect effect on learning and clinical practice by increasing overall knowledge.

CONCLUSIONS

Our results highlight how a medical podcast, designed for continuing professional development, is often used informally to promote learning. These findings enhance our understanding of how and why listeners engage with a medical podcast, which may be used to inform the development and evaluation of other podcasts.
Development of an eHealth Readiness Assessment Framework for Botswana and Other Developing Countries: Interview Study (Preprint)
Authors: Mauco Kabelo Leonard , Scott Richard Ernest , Mars Maurice
Published: December 2018

BACKGROUND

Electronic health (eHealth) readiness has been defined as the preparedness of health care institutions or communities for the anticipated change brought about by programs related to information and communication technology use. To ascertain the degree of such preparedness, an eHealth readiness assessment (eHRA) is needed. Literature on the existing eHRA frameworks and tools shows high inconsistency in content, definitions, and recommendations, and none have been found to be entirely suitable for assessing eHealth readiness in the context of developing countries. To develop an informed eHRA framework and tools with applicability to Botswana and similar developing countries, insight was sought from a broad spectrum of eHealth key informants in Botswana to identify and inform relevant issues, including those not specifically addressed in available eHRA tools.

OBJECTIVE

The aim of this study was to evaluate key informant (local expert) opinions on aspects that need to be considered when developing an eHRA framework suitable for use in developing countries.

METHODS

Interviews with 18 purposively selected key informants were recorded and transcribed. Thematic analysis of transcripts involved the use of an iterative approach and NVivo 11 software. The major themes, as well as subthemes, emerging from the thematic analysis were then discussed and agreed upon by the authors through consensus.

RESULTS

Analysis of interviews identified four eHealth readiness themes (governance, stakeholder issues, resources, and access), with 33 subthemes and 9 sub-subthemes. A major finding was that these results did not directly correspond in content or order to those previously identified in the literature. The results highlighted the need to perform exploratory research before developing an eHRA to ensure that those topics of relevance and importance to the local setting are first identified and then explored in any subsequent eHRA using a locally relevant framework and stakeholder-specific tools. In addition, seven sectors in Botswana were found to play a role in ensuring successful implementation of eHealth projects and might be targets for assessment.

CONCLUSIONS

Insight obtained from this study will be used to inform the development of an evidence-based eHealth readiness assessment framework suitable for use in developing countries such as Botswana.
Bullying di Tempat Kerja di Indonesia
Authors: Silviandari Ika Adita , Helmi Avin Fadilla
Published: December 2018

Workplace bullying is one of organizational phenomenon that has received a lot of attention from many parties, both academics and practitioners. The workplace bullying is like an iceberg phenomenon. It is exist but hard to be revealed and lifted to the surface. This phenomenon can be seen as practically and methodologically point of view. Practically, it is caused by passivity and silent act from the victim or bullying eyewitnesses, and methodologically, it hasn’t found the standard concept of workplace bullying which causing lack of workplace bullying research. In this article, the author try to review the workplace bullying’s concepts and constructs, starting by reviewing the problem of definition, including type, frequency, & duration of bullying actions, and considering the role of workplace cultural values and norms in influencing the perception of bullying behavior.
NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN
Authors: Dholakia Mansi , Dave Richa , Thakkar Vaishali , Rana Hardik , Gohel Mukesh , Patel Nirav
Published: December 2018

Objective: The present research work aims at describing the formulation and evaluation of the ocular delivery system of moxifloxacin hydrochloride (MH) based on the concept of ion sensitive in situ gelations.Methods: In situ gel was prepared by a hot method using 0.6% of gelrite, 0.25% hydroxypropylmethylcellulose (HPMC K4M) and 0.023% tamarind gum as bioadhesive polymers for sustained drug release. Optimization was done by Box Behnken Design with different concentration of gelrite (X1), HPMC K4M (X2) and tamarind gum (X3) as independent variables. In situ gel was optimized based on mucoadhesion index (Y1), Gel strength (Y2) and in vitro drug release (Y3). Influence of the quantitative variable on the dependent variable was predicted by a polynomial equation.Results: Infrared spectroscopy excluded any interaction between drug and excipients. The selected independent variables significantly influenced the responses and were able to sustain the drug release. The prepared gel with a pH of 6.8 to 7.4 exhibited non-newtonian flow with no ocular irritation. The formulation remained stable with no change in pH and viscosity after 30 d of stability study.Conclusion: Thus, moxifloxacin hydrochloride (MH) in situ gel is a viable alternative to a conventional delivery system with the properties of sustained drug release, prolonged ocular retention, and improved corneal penetration.
PHARMACIST INTERVENTION AND PREPARATION OF MANUAL IN THE ADMINISTRATION OF DRUGS THROUGH ENTERAL FEEDING TUBE
Authors: Induja L. , A. Aslam T. , Andhuvan G.
Published: December 2018

Objective: To monitor errors in current practice and prepare a manual for proper drug administration through the enteral feeding tube.Methods: It is a prospective observational study conducted for a period of 6 mo in eight departments. The current drug administrations were monitored and checked for the errors which include crushed non crushable solid dosage forms, each drug is not prepared separately, incorrect solution used for dilution, drugs mixed with feeding formula, each drug is not administered separately, not flushed before administration of each drug, not flushed after administration of each drug and others (tablets are not crushed with proper device, motors and pestles are not cleaned frequently, spillage during crushing). Using the data, a manual was prepared and submitted to the physicians of each department.Results: The most prominent error was found to be that the drugs were not prepared and administered separately, tube not flushed before drug administration. Uses of noncrushable tablets were high in neurology. Pantoprazole (enteric coated) and prazosin (modified release) tablets were the most commonly used noncrushable drugs.Conclusion: The study observed the need for developing a standard protocol for drug administration through enteral feeding tube by the pharmacist along with the physician, nursing team to improve the quality of enteral therapy.
METHOD DEVELOPMENT, VALIDATION AND STABILITY STUDIES FOR THE DETERMINATION OF LURASIDONE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY RP-HPLC
Authors: Thota Bhavani , Adepu Geetha Susmita , Galla Rajitha
Published: December 2018

Objective:  To  develop  a  simple,  rapid,  sensitive,  precise,  accurate,  economical  and  validated reverse  phase  high  performance  liquid  chromatographic  (RP-HPLC)  method  for  the  estimation  of lurasidone hydrochloride in tablet dosage form.Methods:    The  chromatographic  separation  was  carried  out  on  a  prontosil  C18,  AQ  (100 mm×4.6mm,  3µm)  column.  A mixture of phosphate buffer (pH 3.0): acetonitrile (ACN) (55:45v/v) was used as a mobile phase. Flow rate of 1.0 ml/min and 10 μl injection volume was used for the assay.  PDA detector was used and the detection wavelength was 230 nm.  The retention time (RT) of lurasidone hydrochloride was found to be 4.505 ± 0.01 min. The method was validated according to the ICH guidelines.Results:   The   calibration   curve   for   lurasidone   hydrochloride   was   linear   with   correlation coefficient value 0.999 in the concentration range of 25-125%. Specificity, accuracy (% mean recovery, 99.08%), precision, detection limits, robustness (%RSD˂2) and system suitability were found to be within the limits.  Degradation studies were performed under different stressed conditions and the results of degradation studies reveals that the developed method was stable.Conclusion:   The developed method was simple, reliable, economical and stable and it can be applied  for  the  routine  quality  control  analysis  of  lurasidone hydrochloride  in  tablet  dosage forms.
ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF LYGODIUM MICROPHYLLUM IN ALLOXAN INDUCED DIABETIC RATS
Authors: Abdull Majid D. G. Syahidah Nadiah Binti , Iqbal Mohammad
Published: December 2018

Objective: The antihyperglycemic and antioxidative effects of L. microphyllum were evaluated by using in vivo methods in normal and alloxan induced diabetic rats.Methods: Diabetes was induced in Sprague Dawley rats by injecting alloxan through intravenous (i. v) at a dose of 100 mg/kg of body weight. Aqueous extract of L. microphyllum at different doses (400, 200 and 100 mg/kg of body weight) was administered orally (orogastric intubation) for 14 d. Blood glucose and oxidative stress markers were measured. Hematoxylin and eosin staining method were used to examine the pancreatic tissues.Results: At the 14 d interval, fasting blood glucose showed a reduction in serum glucose levels in animals pretreated with L. microphyllum compared with alloxan alone treated group. Oxidative stress was noticed in rat’s pancreatic tissue as evidenced by a significant decrease in glutathione level, glutathione reductase, glutathione-S-transferase, and catalase activities. Malondialdehyde showed a significant increase compared to the normal saline-treated control group. Serum biochemistry and oxidative stress markers were consistent with the pancreatic histopathological studies. Treatment of diabetic rats with L. microphyllum at a dose level of 100, 200 and 400 mg/kg body weight leaves extract for 14 d significantly prevented these alterations and attenuated alloxan-induced oxidative stress (P<0.05).Conclusion: The results of the present study indicated that the antihyperglycemic potential of L. microphyllum might be ascribable to its antioxidant and free radical scavenging properties. Thus, it is concluded that L. microphyllum may be helpful in the prevention of diabetic complications associated with oxidative stress.
EXPLORATION OF MICROORGANISMS AS A POTENTIAL SOURCE OF XANTHINE OXIDASE INHIBITORS: AN UPDATED REVIEW
Authors: Batchu Uma Rajeswari , Surapaneni Joshna Rani
Published: December 2018

Nowadays the prevalence of hyperuricemia has significantly increased in which serum uric acid levels are exceeding the normal range. Gout is the predominant clinical implication of the hyperuricemia, but many clinical investigations have confirmed that hyperuricemia is an independent risk factor for cardiovascular disease (CVD), hypertension, diabetes, and many other diseases. The xanthine oxidase (XO) converts hypoxanthine to xanthine and ultimately to uric acid, and the irreversibly accumulated uric acid causes hyperuricemia associated with gout. Hence specific and selective xanthine oxidase inhibitors (XOI) are potentially powerful tools for inactivating target XO in the pathogenic process of hyperuricemia (Gout). The objective of the current study was to overview the various XOI isolated from the microorganisms. Microorganisms have been employed for several decades for the large-scale production of a variety of bio-chemicals ranging from alcohol to antibiotics and as well as enzyme inhibitors. Currently available XOI (allopurinol and febuxostat) for the treatment of gout have been exhibiting serious side effects. Thus, there is a need to search for new molecules to treat hyperuricemia and its associated disorders. At present, microbes have been unexplored in the development of successful products for the management of XO-related diseases. Hence, the present review focused on novel XOI produced from various microbial species such as Actinobacteria, lichens, bacteria, endophytic fungi and mushrooms, which can be expected to play an important role in the ongoing transition from the empirical screening to the real rational drug design.
SISTEM PAKAR DIAGNOSA PENYAKIT JANTUNG KORONER DENGAN METODE PROBABILISTIC FUZZY DECISION TREE
Authors: Aulia Wizra
Published: December 2018

Di Indonesia, penyakit jantung koroner menempati posisi pertama sebagai penyakit yang paling banyak mengakibatkan kematian. Jika gejala penyakit jantung koroner  dikenali sejak dini maka dapat dilakukan tindakan antisipasi. Diagnosa dilakukan berdasarkan 6 gejala penyakit jantung koroner yaitu sakit dada, tekanan darah tinggi, kolesterol, kadar gula darah, hasil EKG dan jumlah denjut jantung. Metode yang dipakai adalah Probabilistic Fuzzy Decision Tree (PFDT) dengan algoritma  Probabilistic Fuzzy  ID3. Hasil keakuratan sistem pakar diagnosa penyakit jantung koroner dengan metode PFDT mencapai 95%.

In Indonesia, coronary heart disease the first position as the disease that most resulted in death. If symptoms of coronary heart disease are recognized early on, anticipatory action may be taken. Diagnosis is based on 6 symptoms of coronary heart disease  chest pain, high blood pressure, cholesterol, blood sugar, ECG results and heartbeat. The method used is Probabilistic Fuzzy Decision Tree (PFDT) with Probabilistic Fuzzy ID3 algorithm. The result of accuracy of expert system of diagnosis of coronary heart disease by PFDT method reached 95%.
SISTEM INFORMASI PENDAFTARAN DAN PEMBAYARAN BIAYA BIMBEL (Studi Kasus : Bimbel GAMA)
Authors: Azandra Erien Nada
Published: December 2018

Bimbel Gama merupakan salah satu lembaga bimbingan belajar di provinsi Sumatera Barat yang memiliki peminat yang cukup banyak, baik tingkat SD, SMP maupun SMA. Saat ini bimbel Gama sudah memiliki cabang di kota Padang, Bukittinggi, Solok dan Pariaman. Dalam melakukan pengolahan data, terutama data pendaftaran dan laporan keuangan masih menggunakan MS Excel sehingga data tidak tersimpan secara terstruktur dan aman. Termasuk dalam pembuatan slip pembayaran biaya bimbel masih menggunakan kwitansi manual yang ditulis tangan, sehingga bisa menyebabkan terjadinya kesalahan oleh petugas. Untuk mengatasi kesalahan yang mungkin terjadi maka penulis mencoba untuk membangun sebuah system informasi berbasis desktop untuk pengolahan data pendaftaran dan pembyaran biaya bimbel, dimana akan menggunakan MySQL sebagai DBMSnya.
MANAJEMEN PENDISTRIBUSIAN ZAKAT MELALUI PROGRAM UNGGULAN BEASISWA OLEH BAITUL MAL ACEH
Authors: Zabir Muzakir
Published: December 2018

Secara umum umat Islam mengharapkan agar pelaksanaan zakat dapat dilakukan dengan sebaik-baiknya berdasarkan syariâ€™at Islam. Berbagai usaha telah dilakukan oleh pemerintah termasuk ulama dan ilmuwan agar implementasi zakat terlaksana. Untuk itu sebenarnya konsep operasional penerapan zakat, dapat dijadikan contoh dan terus dikembangkan pada masa sekarang, serta diaktualisasikan sesuai dengan pertumbuhan dan tuntutan masyarakat. Dengan memberdayakan zakat secara optimal (mulai dari pemetaan data muzakki, pencatatan muzakki, pengumpulan dana/benda zakat, pendistribusian dana/benda zakat, pemetaan dan pencatatan penerima zakat) yang selalu diupdate, masalah perekonomian khususnya tentang kemiskinan finansial masyarakat kita akan mendapat enjeksi solutif, sehingga kita akan melihat lahirnya masyarakat yang sejahtera dari sisi ekonomi.
PELAYANAN PENASEHAT AKADEMIK (PA) DALAM MENINGKATKAN PRESTASI MAHASISWA
Authors: Fakhruddin Fakhruddin , Safrianti Eka
Published: December 2018

Tujuan dari penelitian ini adalah mengkaji pelayanan Penasehat Akademik dalam memberikan bimbingan bagi mahasiswa untuk meningkatkan prestasi mahasiswa sehingga ditemukan hambatan atau kendala yang dihadapi penasehat akademik (PA) dalam memberikan layanan bimbingan akademik yang berdampak pada prestasi mahasiswa. Penelitian ini adalah penelitian lapangan dengan menggunakan pendekatan kualitatif. Pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi pada Fakultas Dakwah an Komunikasi UIN Ar-Raniry. Hasil penelitian menunjukkan bahwa Penasehat Akademik telah memberi motivasi, bimbingan, dan arahan yang baik terhadap mahasiswa serta pelayanan sesuai dengan aturannya dalam meningkatkan prestasi mahasiswa. Namun dalam pelaksanannya terdapat beberapa hambatan atau kendala yang dihadapi Penasehat Akademik (PA) dalam pelayanan bimbingan mahasiswa antara lain keterbatasan waktu Penasehat Akademik, ketidakseimbangan rasio antara jumlah Penasehat Akademik dan mahasiswa perwalian, dan kedisiplinan mahasiswa dalam mengikuti jadwal bimbingan akademik yang telah ditetapkan oleh Sub.bidang akademik.
SISTEM REHABILITASI KORBAN NARKOBA MELALUI PENDEKATAN DAKWAH DI YAYASAN TABINA ACEH KABUPATEN ACEH BESAR
Authors: Habibi Khairul
Published: December 2018

Narkoba berdampak buruk serta menimbulkan banyak keluhan sampai merenggut nyawa para penggunanya. Ini merupakan masalah serius untuk dihadapi bersama sehingga pemerintah Aceh Besar membentuk Yayasan Tabina Aceh untuk merehabilitasi korban penyalahgunaan narkoba. Adapun tujuan dalam penelitian ini adalah untuk mengetahui program rehabilitasi korban narkoba yang dilakukan Yayasan Tabina Aceh selama ini dan untuk mengetahui keberhasilan dan kendala yang dihadapi Yayasan Tabina Aceh dalam rehabilitasi korban narkoba serta untuk mengetahui sistem rehabilitasi korban narkoba dengan pendekatan dakwah di Yayasan Tabina Aceh. Penelitian ini termasuk pada penelitian kualitatif dengan menggunakan analisis deskriptif. Teknik pengumpulan data dilakukan dengan observasi, wawancara dan studi dokumentasi. Bedasarakan hasil penelitian, program rehabilitasi yang dijalankan oleh Yayasan Tabina Aceh sudah tergolong baik, yaitu melalui cara isolasi, detoksifikasi, pemberian obat secara medis. Sistem rehabilitasi korban narkoba di Yayasan Tabina Aceh dilakukan melalui pendekatan dakwah, seperti melalui ibadah shalat, puasa, zikir, tausiah agama, membaca al-Quran dan ruqiyah syarâ€™iyah. Sedangkan kendala yang dialami dalam rehabilitasi diantaranya keterlambatan pada pola berpikir, depresi, enggan dan kurangnya dukungan keluarga dalam membantu korban untuk mendapatkan kesembuhan.
PESAN DAKWAH FELIX SIAUW DI MEDIA SOSIAL (PERSPEKTIF MEANING AND MEDIA)
Authors: Farhan Farhan
Published: December 2018

Tulisan ini dimaksudkan untuk menganalisis secara kritis tentang dakwah era gadget perspektif meanings dan media: studi pesan dakwah Felix Siauw (1984-2015) di media sosial periode Maret 2015. Dengan menggunakan perspektif teori meanings and media (Branston dan Stafford, 2003: 9-33), penelitian ini mencoba menelaah pesan dakwah yang disampakan daâ€™i melalui media sosial. Daâ€™i diposisikan sebagai sign, pesan dakwah sebagai signifier dan Felix Siauw sebagai signified. Penelitian ini merupakan studi kasus pada media massa online. Sumber data penelitian didapatkan dari dokumentasi online. Pesan dakwah tersebut ditulis pada facebook (visual) periode Maret 2015. Analisis kualitatif deksriptif digunakan untuk menganalisa data yang telah terkumpul. Berdasarkan hasil penelitian, pesan dakwah yang disampaikan Felix Siauw melalui media sosial menunjukkan karakteristik yang unik. Pertama, intisari pesan adalah ketauhidan sebagai implementasi dari amar maâ€™ruf nahi munkar dengan membidik problematika kekinian. Kedua, objek pesan dielaborasi dengan pangsa pasar masyarakat melek teknologi. Ketiga, pesan didominasi adanya indikasi pemurnian Islam di Indonesia dalam kehidupan berbangsa dan bernegara.