bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship Of Brand Image, Trust and Value on Purchase Intention of Hotels Using Online Technology in China
Authors: Hoo Wong Chee , Guodian Wu , Wolor Christian Wiradendi , Ling Zhu , Prompanyo Manoch
Published: August 2024

According to a 2015 survey on Chinese outbound tourist consumption, more than a third of Chinese tourists saw travel as equally important as learning and education, career development, child growth, and family wealth. This led to a significant improvement in both the well-being of individuals and their quality of life indicators. When customers have a wider range of options to choose from when making reservations, they are more likely to encounter difficulties in incorporating all of these choices. When customers interact with these forces in the same manner as they do with other forces, conventional variables such as brand image, price, trust, and value will significantly influence their decisions. This means that consumers will interact with these forces in the same manner. We are conducting this study to identify the factors that influence customers' purchase intentions when they make hotel or online reservations in China. The study gathered the information from 392 individuals who responded to the questionnaire. We performed an analysis of the obtained data using SPSS. The conclusion that can be drawn from this is that there is a substantial association between the dependent variable, which is the consumer's desire to make a purchase while booking a hotel online, and three independent factors, namely brand image and trust. On the other hand, we found that the price significantly influences the customer's desire to make a purchase when they book a hotel online. According to the findings of this research, it is possible to draw the conclusion that consumers in China have the same viewpoint and concerns as consumers in other countries when it comes to booking a hotel via an online platform.
COXSACKIE VIRUS A5 CIRCULATION IN THE EUROPEAN PART AND IN THE EAST OF RUSSIA
Authors:   FBIS Academician Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor (Federal Service on Surveillance and Consumer Rights Protection and Human Walfare), Russian Federation, Nizhny Novgorod, Ponomareva N.V.
Published: August 2024

Over the past few years, the number of cases of HFMD diseases associated with Coxsackievirus A5 (CVA5) infection has increased worldwide. The detection rate of this virus has become comparable to the currently dominant pathogens: CVA6, CVA16, CVA10 and Enterovirus A71. The dynamics of CVA5 circulation in the European part and eastern regions of Russia in the period 2013-2023 is characterized. The genetic diversity and phylogenetic relationships of strains identified in the Russian Federation and other countries are studied. The virus was detected annually, with the exception of 2020, detection peaks were recorded in 2018 and 2023. The proportion of CVA5 in the structure of etiological agents of enterovirus infection averaged 4.27%, in the structure of identified Enterovirus A viruses – 7.25%. CVA5 infection was more often manifested in the form of acute respiratory disease 33.05%, herpangina – 22.88%, HFMD – 16.95%. The Russian CVA5 strains were characterized by genetic heterogeneity, manifested by the simultaneous circulation of viruses belonging to different genotypes and genovariants.
RESULTS OF SEROLOGICAL SCREENING OF THE KHABAROVSK KRAI POPULATION FOR SPECIFIC IMMUNOGLOBULINS AGAINST PARASITIC INVASIONS IN 2023
Authors:   FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, Russian Federation, Khabarovsk, Moskvina Yu.I. , Gaer S.I. ,   FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, Russian Federation, Khabarovsk, Dragomeretskaya A.G. ,   FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, Russian Federation, Khabarovsk, Trotsenko O.E. ,   FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, Russian Federation, Khabarovsk
Published: August 2024

Current article presents results of research on immune structure of the Khabarovsk krai population against infectious agents of parasitic diseases in 2023. The results of the research indicate a contact between region population and causative agents of parasitic invasions and confirm importance of optimization of epidemiological surveillance diagnostic system over parasitic diseases.
National Drowning Report 2023
Authors: Koon William , Miller Lauren , Pickles Katrien , Lawes Jasmin , Kelly Sean , Daw Shane
Published: August 2024

The National Drowning Report 2023 provides an analysis of fatal drowning across Australia between 1 July 2022 and 30 June 2023. This analysis is designed to help water safety organisations, community members, and those who manage water spaces reduce the risk of drowning. Data was collated from the National Coronial Information System (NCIS), State and Territory Coronial offices, lifesaving organisations, and year-round media monitoring. There were 281 drowning deaths in the one-year study period; detailed analysis presents fatal drowning by age, sex, location of drowning, activity prior to submersion, State / Territory and other variables.
E-COMMERCE OPERATIONS WITH AI-POWERED DATA WAREHOUSES: A CASE STUDY ON CUSTOMER BEHAVIOR ANALYSIS
Authors:   Master of Science in Information Technology, Washington University of Science and Technology,Virginia, USA, Hossen Kazi Md Riaz
Published: August 2024

This paper presents a comprehensive systematic review of the impact of AI-powered data warehouses on e-commerce operations, with a particular focus on customer behavior analysis and operational efficiency. Leveraging the PRISMA methodology, the study synthesizes findings from 70 research articles spanning multiple countries, including the United States, China, India, the United Kingdom, and Germany. The review highlights the transformative role of AI-driven data warehouses in enabling real-time, predictive analytics, which significantly enhances the ability of e-commerce businesses to understand and respond to customer preferences, optimize inventory management, and implement dynamic pricing strategies. While the benefits of AI integration are substantial, the study also identifies persistent challenges, such as data privacy concerns, high implementation costs, and integration complexities, that may hinder widespread adoption. The paper concludes with recommendations for businesses to strategically approach the implementation of AI-powered data warehouses, emphasizing the need for scalable solutions, robust data governance, and ongoing investment in technology and training. This research underscores the potential of AI-powered data warehouses to drive innovation and growth in the e-commerce sector, while also calling for continued exploration of solutions to address the existing challenges.
Factors Affecting Physicians' Research Activities in the Hospitals of Ministry of Health at Sultanate of Oman
Authors: Al-Dhuhli Sa’ada , Jabr Naeema
Published: August 2024

The study aimed to investigate the individual and institutional factors affecting the quality of physicians' research activities. It also purposed to indicate which factors have more effect on research activities, and are those factors affected each other's.. This will help to formulate knowledgeable environment between researchers to exchange experiences, pursuit research process and to find the best solution to enhance and develop health research activities in the Sultanate.Accordingly, the study purposed to answer the following questions:1. Which factors, including in the individual factors (personal interest, skill & competencies of researcher, information retrieval and communication & collaboration) and institutional factors (training & education, Funding and incentives) have more effects the physicians' research activities?2. Is there any correlation between individual and institutional factors and between factors themselves?Also the study examined this theory: There are significance differences between physicians' categories (professional and specialty level, age and hospital level).The qualitative method was used to achieve the aim of the study.Questionnaire was used for data collection from (465) physicians working in the referral hospitals of Ministry of Health (MOH).The SPSS statistical package was used to analyze the data by conducting several tests, T-test, one way ANOVA and correlation.The study found that, Individual factors affected physicians' research activities more than institutional factors. However, there was no correlation appeared between both types of factors. At the time, there were significant differences between individuals and institutional factors affecting research activities and professional and specialty levels of physicians. Insight of these results, the study recommended enhancement of communication and collaboration culture, and create database to achieve the effective collaboration between physicians. On the hand of institutional factors, the study recommended to prepare continuous training and provide the resources, materials and funds that should motivate research activities.
Halatuju Pelajar TVET: Pengaruh Minat Terhadap Niat Kerjaya Pelajar Teknologi Automotif Di Kolej Vokasional Daerah Johor Bahru
Authors: Haron Mohamad Zhurad , Sumeri Mohd Nasrun
Published: August 2024

Bidang teknologi automotif merupakan salah satu disiplin ilmu yang berkembang pesat di seluruh dunia, terutamanya dengan kemajuan teknologi yang pesat dalam industri automotif. Minat pelajar terhadap subjek teknologi automotif menjadi aspek penting dalam menentukan niat kerjaya mereka dalam bidang ini. Kajian ini bertujuan mengkaji hubungan antara minat dan niat kerjaya pelajar dalam bidang teknologi automotif di sebuah Kolej Vokasional dalam daerah Johor Bahru, Johor. Objektif utama kajian adalah untuk mengenal pasti tahap minat pelajar terhadap subjek teknologi automotif dan niat mereka untuk bekerja dalam bidang menservis automotif. Kajian menggunakan pendekatan kuantitatif dengan populasi seramai 134 pelajar kohort Program Teknologi Automotif di sebuah Kolej Vokasional. Kajian ini menggunakan instrumen soal selidik dengan skala Likert 5 mata untuk mengukur persepsi minat dan niat mereka. Data yang dikumpul dianalisis menggunakan analisis deskriptif dan inferensi untuk memahami hubungan antara faktor yang dikaji. Hasil kajian menunjukkan tahap minat dan niat pelajar berada pada tahap yang sangat tinggi. Analisis inferensi mendapati terdapat hubungan yang signifikan antara minat dan niat kerjaya pelajar. Minat yang mendalam terhadap sesuatu bidang meningkatkan motivasi intrinsik pelajar dan seterusnya mengarah kepada niat untuk mengejar kerjaya dalam bidang tersebut. Kesimpulan ini memberi implikasi penting kepada institusi pendidikan dalam menarik dan mengekalkan minat pelajar dalam bidang teknologi automotif.
Manejo da dor pós-operatória em crianças submetidas a cirurgias ortopédicas
Authors: Hussien Ali Mustapha  , Livia Catarina Lopes Vianna Couto  , Anna Isabel Rocha de Oliveira  , Ágatha Beatriz Iurchevicz  , Guilherme Ribeiro Xavier  , João Francisco Meira Valadares  , Enzo Fabrizzio Moretto Lusvarghi  , Gustavo Smit Schlosser  , Cendi da Cruz Oliveira de Freitas  , Eliseu Ribeiro Caldas  , Raysa Rangel Rodrigues  , Leonardo Naoki Maciel Miki  , Mateus Luiz de Godoi  , Laura Lange Vicente  , Matheus da Silva Ribeiro  , Maurício Caetano Lourenço Filho
Published: August 2024

O manejo da dor pós-operatória em cirurgias ortopédicas na população infantil é um desafio para a equipe médica e, quando realizada de maneira incorreta, acarreta em riscos aumentados de insatisfação do paciente e de morbimortalidade. Em relação ao tratamento, ainda existem lacunas na literatura para o manejo correto da dose dos medicamentos opioides e da magnitude da dor. METODOLOGIA: Trata-se de uma revisão integrativa da literatura da base de dados PUBMED. Foi utilizado os descritores: “CHILDREN AND PAIN AND POSTOPERATIVE AND ORTHOPEDIC’’. Foram selecionados artigos científicos do período de 2019 a 2024. RESULTADOS: Atualmente, o manejo da dor pós operatória em cirurgias ortopédicas pediátricas é uma prioridade. A administração de opioides diminuem o nível de dor após o terceiro dia de pós operatório. Entretanto, o seu uso pode mascarar síndromes compartimentais e isquemias. A prescrição excessiva de opioides por cirurgiões pode ocasionar em um aumento da retenção comunitária desses medicamentos, contribuindo para o seu uso ilegal. A avaliação subjetiva da dor pós operatória de crianças pode ter influência de uma série de fatores, incluindo o medo e estresse emocional. Nesse sentido, médicos podem subestimar essas queixas, enquanto que os pais tem uma tendência de superestima-las. CONCLUSÃO: Os opioides são os principais medicamentos para o manejo da dor em pacientes pediátricos submetidos a cirurgias ortopédicas. No entanto, é importante estar em alerta aos potenciais efeitos colaterais, ao uso indevido e à avaliação correta da dor.
Strategies for Developing Speaking Skills by Utilizing Language Learning Podcasts
Authors: Mohzana Mohzana
Published: August 2024

Background. Speaking skill development is a crucial aspect of language learning. This study aims to explore the effectiveness of podcasts as an innovative strategy in the development of speaking skills, opening up opportunities for further research into more progressive language learning methods.
Purpose. The study aims to provide an in-depth understanding of the role of podcasts in the development of speaking skills and explore the potential of innovative language learning methods.
Method. A quantitative approach with survey method was used, involving 25 Arabic and English language students as the sample. Data was collected through a questionnaire distributed through Google Form, with analysis using the Miles Huberman approach and data visualization in the form of charts to understand the percentage of responses.
Results. From the questionnaire results, it appears that podcasts play an important role in the development of speaking skills. The varying frequency of use reflects the high level of student interest and engagement with the audio material. While most respondents saw the benefits of podcasts in improving confidence and language acquisition, the neutral responses provided opportunities for adjustments to the learning approach.
Conclusion. The conclusions of this study provide a basis for designing more targeted learning strategies, considering the diversity of student experiences and needs.
Student Perception of the Effectiveness of the Storytelling Method in English Learning: Quantitative Research with a Focus on Reading Skills
Authors: Syam Hariadi , Almeina Loebis Iin , Nurwiatin Neng , Srisudarso Mansyur , Irwansyah Defi
Published: August 2024

Background. The storytelling method has become a popular approach in English language learning due to its ability to increase student interest and participation. However, quantitative research specifically focussing on the effectiveness of this method in the development of reading skills is limited.
Purpose. This study aims to investigate students' perceptions of the effectiveness of the storytelling method in English language learning, with a focus on the development of reading skills.
Method. This study uses a quantitative approach by distributing questionnaires to students who are learning English. The questionnaire measured students' perceptions of the effectiveness of the storytelling method in improving their reading skills.
Results. The results showed that most students (83.3%) believed that the storytelling method was effective or very effective in improving their interest and understanding of reading skills. However, a small proportion of students (16.7%) had a neutral view on the effectiveness of this method.
Conclusion. The findings of this study indicate that the storytelling method is effective in improving students' reading skills in English language learning. By considering students' perceptions and integrating the storytelling approach into the curriculum, educators can enhance students' learning experiences and support the development of reading skills more effectively.
The Influence of the Direct Method on Students' Language Comprehension: Quantitative Research with a Focus on Listening Skills
Authors: Wardhani Rizky , Danial Haris , Miranty Delsa , Oktaviana Ariana , Fitriani Nining
Published: August 2024

Background. The Direct Method has become an attractive approach in language learning, emphasising the use of the target language in communicative situations. However, the impact of the Direct Method on students' language comprehension, particularly in listening skills, still needs to be studied in depth.
Purpose. This study aims to evaluate the effect of the Direct Method on students' language comprehension, focusing on listening skills in the context of English language learning.
Method. A quantitative approach was used to analyse data from the listening comprehension scores of students who took the Direct Method. The research sample consisted of 100 students who took the Direct Method course.
Results. The results showed that the Direct Method had a positive and significant influence on students' listening comprehension ability. Of the 100 students who took the course with the Direct Method, 85% showed a significant improvement in listening comprehension scores.
Conclusion. In the context of English language learning, the Direct Method has great potential in improving students' listening comprehension. This approach provides an interesting and meaningful learning experience for students, allowing them to be actively involved in the learning process and improving their ability to understand and use the target language.
NEUTRALIZACIÓN Y REMOCIÓN DE METALES PESADOS DE AGUAS ÁCIDAS DE MINA MEDIANTE EL USO DE ORINA HUMANA
Authors: Paniagua Coca Matilde Marisol
Published: August 2024

Uno de los principales contaminantes que se generan de la actividad minera, son las aguas ácidas más conocidas como “Aguas de Copagira”, que emanan constantemente de los socavones, por el pH bajo que reportan se caracterizan por ser muy ácidas y por tanto corrosivas, lo que ocasiona que a su paso vayan degradando la naturaleza, convirtiendo en lugares insalubres y desérticas. Considerando que estas aguas son bastante ácidas y además que contienen una carga importante de metales pesados, su tratamiento requiere alternativas nuevas. El objetivo es la neutralización y remoción de metales pesados de estas aguas ácidas, utilizando sustancias de desecho en este caso la orina humana que después de un proceso de fermentación en la cual los componentes de éste, se transforman en sustancias alcalinas que ayudan a la neutralización y a la precipitación de los metales pesados que contienen estas aguas, minimizando de esta forma la agresividad al medio ambiente. Para la ejecución del proceso se siguió los siguientes pasos: Recolección de 10 litros de orina, Caracterización fisicoquímica de la orina recolectada, Acondicionamiento y posterior fermentación de la orina, caracterización  de la orina fermentada – análisis de pH, recolección de aguas de mina, caracterización fisicoquímica de las aguas de mina, neutralización y precipitación de los metales pesados que contienen estas aguas, caracterización de las aguas tratadas de mina, Este trabajo de investigación tiene un alcance a nivel semipiloto que puede seguir a nivel piloto e industrial.
La arepa, el territorio, el maíz y el drama
Authors: Cartay Rafael
Published: August 2024

En este artículo se examinan cuatro temas relacionados con la arepa, unpatrimonio alimentario compartido por los venezolanos y los colombianos, que la consideran un elemento ligado estrechamente a su respectivas identidades gastronómicas: la preparación culinaria, sus antecedentes, características, semejanzas y diferencias de su inserción en las dos culinarias; la planta de maíz y su dispersión en el territorio americano, desde su centro primario de origen en México y Mesoamérica y, por último, la situación dramática que resulta de que un alimento básico en la alimentación nacional, cargado de significaciones y uno de los principales exponentes de la identidad gastronómica nacional, dependa de crecientes importaciones, creando un problema grave de soberanía alimentaria.
La Fanesca como recurso turístico: Un viaje culinario a través de la cultura ecuatoriana
Authors: Guevara Aroca Francisco Xavier
Published: August 2024

La Fanesca, una sopa emblemática de la Semana Santa en Ecuador, es un crisol de sabores que refleja la riqueza cultural del país. Su origen se remonta a la época colonial, donde se fusionaron ingredientes indígenas y españoles. Este plato único, con su variedad de granos, verduras, bacalao y otros elementos, ha trascendido el tiempo convirtiéndose en un ícono gastronómico ecuatoriano. Más allá de su sabor, la Fanesca encierra un profundo significado cultural. Es símbolo de comunión y unidad familiar, transmitida de generación en generación. Su preparación, llena de tradiciones y secretos familiares, se convierte en un acto de unión y celebración. En este contexto, la Fanesca se presenta como un recurso turístico invaluable. Su potencial radica en la búsqueda de experiencias auténticas por parte de los visitantes. A través de ferias gastronómicas, clases de cocina y rutas turísticas, se puede promover el consumo local, fortalecer la identidad cultural y fomentar el desarrollo sostenible de las comunidades. La promoción de la Fanesca como un producto cultural único y auténtico posicionará al Ecuador como un destino atractivo para los amantes de la gastronomía y las tradiciones ancestrales.
Cocina y Religión: La Fanesca y su Significado Espiritual en Ecuador
Authors: Arellano Guerrón Sonia Lorena
Published: August 2024

La fanesca, sopa tradicional de la gastronomía ecuatoriana, trasciende su función culinaria para convertirse en un símbolo arraigado en la identidad cultural y religiosa del país, especialmente durante la celebración de la Semana Santa. Este ensayo explora la historia, los ingredientes significativos y el papel religioso de la fanesca, revelando su intersección entre la comida, la cultura y la espiritualidad en el contexto ecuatoriano. Desde las antiguas ofrendas culinarias en civilizaciones como la griega y la egipcia hasta la influencia de la cocina mestiza en América Latina, la relación entre comida y religión ha sido evidente a lo largo de la historia. La fanesca incorpora una mezcla de ingredientes que representan la diversidad cultural y agrícola de Ecuador, fusionando tradiciones indígenas con influencias europeas. Cada ingrediente de la fanesca tiene un significado simbólico durante la Semana Santa, reflejando aspectos centrales de la fe cristiana y transmitiendo valores religiosos y culturales a través de la comida. La fanesca no solo alimenta el cuerpo, sino que también nutre el alma y fortalece los lazos comunitarios, siendo un recordatorio vivo de la importancia de preservar y valorar las tradiciones culinarias como parte integral del patrimonio cultural de Ecuador.
IMPROVING THE EFFICIENCY OF OPERATION OF COMPLICATED OIL AND GAS WELLS
Authors: ALMATOVA B.G  , BALGYNOVA A.M  , SARKULOVA ZH.S.  , TUREZHAN A.T.
Published: August 2024

«Қиындатылған мұнай және газ ұңғымаларының пайдалану тиімділігін арттыру» көмірсутектерді тұрақты және тиімді өндіруді қамтамасыз ету үшін ұңғымаларды өндіру және пайдалану процестерін оңтайландыру қажеттілігі артып келе жатқан қазіргі мұнай-газ өнеркәсібі контекстінде өзекті болып табылады.Зерттеу мұнай және газ ұңғымаларын, әсіресе күрделі геологиялық жағдайлармен, сұйықтықтардың жоғары тұтқырлығымен, агрессивті компоненттердің болуымен және басқа да қиындықтармен сипатталатын ұңғымаларды пайдалану тиімділігін арттыруға қабілетті инновациялық тәсілдер мен технологияларды анықтауға бағытталған.Зерттеу мұнай мен газды өндіруде қолданылатын қолданыстағы технологияларды, әдістер мен құралдарды олардың кемшіліктері мен оңтайландыру мүмкіндіктерін анықтау үшін талдауды қамтиды. Ұңғыма операторларына жылдам шешім қабылдау үшін өзекті ақпаратты бере алатын интеграцияланған басқару және мониторинг жүйелерін әзірлеуге ерекше назар аударылады.Зерттеу барысында шығындарды азайтуға және көмірсутектерді өндірудің тиімділігін арттыруғабағытталған жаңа технологиялық шешімдерді әзірлеу көзделеді. Бұған корпус үшін жаңа материалдар жасау, геологиялық құрылымды зерттеудің озық әдістерін қолдану, сондай-ақ өндірісті қарқындату әдістерін оңтайландыру кіруі мүмкін.Осы зерттеудің нәтижелері мұнай және газ өндіру өнеркәсібінде ғана емес, сонымен қатар энергетика ресурстарын тұрақты және тиімді пайдалануға бағытталған энергетика саласындағы саясатты әзірлеу саласында да пайдаланылуы мүмкін.
ЭЛЕМЕНТЫ ТЕХНОЛОГИИ ДОПОЛНЕННОЙ РЕАЛЬНОСТИ НА УРОКАХ ГЕОМЕТРИИ
Authors: К.П. АМАН  , А.А.УТЕГЕНОВА
Published: August 2024

Мақалада толықтырылған шындық технологиясының мүмкіндіктері көрсетілген, яғни оқу және жобалық жұмыстарда қолдануға мүмкіндік береді. Ұсынылған жұмыстың мақсаты толықтырылған шындық технологиясын өз сабақтарында және мұғалімдерге, студенттердің жобалық қосымшалар дайындауда қолдану үшін толықтырылған шындық технологиясын зерттеуде қолдана алады. Бұл жұмыста 7-сыныптағы геометрия сабақтарында, атап айтқанда, планиметриялық есептерді оқу кезінде толықтырылған шындық технологиясының элементтерін пайдалану ұсынылады. Бұл тапсырмалармен тікелей әрекеттесуге, жауаптарды көруге, сондай-ақ қажетті ақпаратты шақыруға мүмкіндік беретіні көрсетілді. Толықтырылған шындық технологиясын оқу үрдісінде қолдану мұғалімнің біліктілігін арттырудың маңыздылығы ашылды. Сондай-ақ, AR қосымшаларын жасау бойынша жұмыс процесінде студент жобалық қызметпен сәтті айналыса алатыны айтылған. Толықтырылған шындық технологиясы студенттердің шығармашылық және кеңістіктік қабілеттерін ашуға көмектеседі, сонымен қатар оқу мотивациясына ықпал етеді. Қазіргі уақытта интерактивті цифрлық технологиялардың қарқынды дамуы жаңа кәсіптердің негізінде сұранысқа ие құзыреттер мен дағдылардың тізімін үнемі өзгертіп отырады. Осының нәтижесінде ойлау қабілеті барынша икемді және шығармашылық қабілеті жоғары, шығармашылық әлеуеті зор, өз бетінше әрекетке де, топтық жұмысқа да дайын мамандарға сұраныс артуда.
IMPROVING THE EFFICIENCY OF OPERATION OF COMPLICATED OIL AND GAS WELLS
Authors: ALMATOVA B.G  , BALGYNOVA A.M  , SARKULOVA ZH.S.  , TUREZHAN A.T.
Published: August 2024

"Improving the efficiency of operation of complicated oil and gas wells" is relevant in the context of the modern oil and gas industry, where there is a growing need to optimize the processes of production and operation of wells to ensure sustainable and efficient production of hydrocarbons.The research is aimed at identifying innovative approaches and technologies that can improve the efficiency of oil and gas wells, especially those characterized by complicated geological conditions, high fluid viscosity, the presence of aggressive components and other difficulties.The study includes an analysis of existing technologies, methods and tools used in oil and gas production inorder to identify their shortcomings and opportunities for optimization. Particular attention is paid to the development of integrated management and monitoring systems capable of providing well operators with up-to-date information for quick decision-making.In the course of the research, it is also expected to develop new technological solutions aimed at reducing costs and increasing the efficiency of hydrocarbon production. This may include the creation of new materials for casing pipes, the use of advanced methods of geological structure research, as well as the optimization of production intensification methods.The results of this study can be used not only in the oil and gas production industry, but also in the development of energy policy aimed at sustainable and efficient use of energy resources.
КВАЗИМЕМЛЕКЕТТІК СЕКТОР СУБЬЕКТІЛЕРІНДЕГІ КОМПЛАЕНС ҚЫЗМЕТТЕР: СЫН-ТЕГЕУРІНДЕР МЕН ДАМУ ПЕРСПЕКТИВАЛАРЫ
Authors: Ж.Ж. ДАВЛЕТБАЕВА  , Н.С. ҚАЛАУОВ
Published: August 2024

Комплаенс институты халықаралық деңгейде дәлелденген, жемқорлық тәуекелдерімен күресті тиімді құрал болып табылады. Мақалада квазимемлекеттік сектор субьектілеріндегі сыбайласжемқорлыққа қарсы компаленс-қызметтің сыбайлас жемқорлық тәуекелдерінің алдын алудағы маңызыайқындалған. Қазақстан тәжірибесіндегі комплаенс-қызметтің өзекті мәселелері сараланған. Соңғы төрт жылға жуық уақыттағы комплаенс-қызметті ұйымдастырудағы сақталып отырған проблемалар сарапшылар арқылы зерделенген. Әсіресе, тікелей бағыныстылығы бар ұйымдардағы комплаенс қызметтің тәуелсіз қызметіне мән берілген. Қазіргі қолданыстағы сыбайлас жемқорлыққа қарсы комплаенс-қызмет туралы үлгілік ерженің баршаұйымға біріңғай талаппен жасалуы, жұмыс тиімділігінее әсер ететіні атап өтілген. Ағымдағы жағдайды айқындау мақсатында квазимемлекеттік сектор субьектілеріндегі комплаенс-қызмет мамандарынан жасырын түрде онлайн-сауалнама алынған. Сауалнама нәтижелері комплаенс қызметтің ұйым басшысына тәуелділігі, кадр әлеуетінің төмендігі мен бизнес-процестерді ұйымдастырудың төмендігін көрсеткен. Ресей менҚазақстандағы комплаенс-қызметтің артықшылықтары, әлсіз тұстары, мүмкіндіктері мен тәуекелдері талданған. Зерттеушілер тарапынан комплаенс-қызметтің тиімділігін арттырудағы аутсорсинг тәсілінің тиімділігі көрсетілген. Квазимемлекеттік сектор субьектілеріндегі сыбайлас жемқорыққа қарсы комплаенсқызмет туралы үлгілік ережеге комплаенс-қызметтің функциялары мен процестерінің бір бөлігін аутсорсингке беру бойынша өзгерістер мен толықтырулар енгізу ұсынылған. Комплаенс-қызметтің тәуесіздігін арттырудағы ұсынылып отырған шешімнің жалпы сыбайлас жемқорлық тәуекедерінің алдын ау мен азайтуда оң нәтиже беретіні жөнінде тұжырым жасалған.
Exploring Course Leaders’ Reflections of Learning Communities at Sheffield Hallam University
Authors: Donnelly Alan , Parsons Rachael , Pearson Daniel
Published: August 2024

The overarching aim of the project was to explore and capture examples of practices and ideas for success to enhance the course experience for students, with a particular emphasis on the theme of learning communities. Learning communities was an area that received a notable decrease in student satisfaction in the 2021 National Student Survey (NSS) at Sheffield Hallam University. Interviews were carried out with eight course leaders to explore: the practices used on their courses; the aspects that could be made even better; the evidence that they draw upon to understand the effectiveness of these practices. The following themes were identified: 1) staff-student relationships; 2) curriculum content and pedagogy; 3) peer networks and relationships; 4) supportive relationships between staff members; 5) societies and external networks. The practices identified by course leaders were consistent with practices identified in other relevant literature.
Impact of the Covid-19 Pandemic on the Doctor-Patient Relationship: A Qualitative Study in a Tertiary-Care Centre in Lebanon
Authors: Abou-Mrad Tatiana , Haidar Hazar , Abou-Mrad Fadi , Arawi Thalia
Published: August 2024

Background: The Covid-19 pandemic imposed numerous constraints on medical practice and exacerbated preexisting vulnerabilities in Lebanon’s healthcare system, which was already grappling with instability due to concurrent political and economic crises. This situation had a complex impact on the doctor-patient relationship (DPR), with both negative and positive repercussions. Methods: We conducted semi-structured interviews with physicians from various specialties practicing at a tertiary-care center in Lebanon. Our study aimed to 1) explore the impact of the Covid-19 pandemic on the DPR in Lebanon, and 2) provide recommendations for improving the DPR, healthcare policy, and education. Results: Thematic analysis of the data revealed that the pandemic had varying effects on the DPR. While both physicians and patients seemed to have developed a more favourable perception of the medical profession, communication between them appeared to be challenged by the use of personal protective equipment and patients’ concerns about close contact with physicians. The media played a vital role in educating and raising awareness during the pandemic but lacked organization and ethical standards, leading to anticipated fear and confusion among the society. Telemedicine emerged as an alternative means for communication and remote care but faced several obstacles including inadequate internet infrastructure and disruptions to physicians’ personal lives. Conclusion: Our qualitative study unveiled the multifaceted impact of the Covid-19 pandemic on perceiving the healthcare system, doctor-patient interactions, and the role of telemedicine in Lebanon, among others. These findings underscore the importance of effective communication in enhancing the DPR, the need to address misinformation on social media, and the imperative for systemic improvements to strengthen the resilience of Lebanon’s healthcare system.
Equal Respect, Equitable Treatment: Core Commitments for Responding to Diversity and
Inequality in the Health System
Authors: Rink Susan , Jiwani Bashir , Adurogbangba Mojisola
Published: August 2024

The Fraser Health Authority (FHA) has established a framework of commitments to
guide a range of issues from incorporating diversity, equity, and inclusion in clinical and
policy decisions and responding to the historical and continuing discrimination against
First Nations, Métis, and Inuit peoples, to creating psychologically safe environments, and
dealing with harassment, bullying and other disrespectful behaviours. FHA Ethics Services
hosted a workshop as part of the 2023 Canadian Bioethics Society-Société canadienne de
bioéthique (CBS-SCB) Workshop and Community Forum to create an opportunity for critical
reflection and discuss strategic responses for the organization to live up to these
commitments. This paper summarizes the workshop and identifies key insights and issues that
emerged as areas that should be addressed in responding to diversity and inequality in the
health system.
Addressing Ethical Challenges Related to Community and Patient Engagement in Health
Research
Authors: Cordeaux Emily , Sheikhan Natasha Yasmin , Boateng Rhonda
Published: August 2024

In this post-workshop summary, we describe three ethical challenges related to
engaging people with lived experience as partners in health research. We share learnings and
reflective prompts from our workshop delivered as part of the Canadian Bioethics Society
Workshop and Community Forum held in May 2023.
Bagdonių sentikių bendruomenė Lietuvoje ir Altajaus krašte XIX a. antrojoje pusėje – XX a. pirmojoje pusėje
Authors: Kašiubaitė Akvilė
Published: August 2024

Straipsnyje atskleidžiamos XIX a. antrosios pusės Kauno gubernijos Kupiškio krašto Bagdonių sentikių parapijos bendruomenės ypatybės ir XX a. pradžioje susiklosčiusios aplinkybės, dėl kurių 1908 m. dalis bendruomenės narių savo noru išvyko į Sibirą. Remiantis įrašu, rastu ant tarptautiniame meno kūrinių aukcione parduoto sentikių kryžiaus, XIX a. vidurio teismo bylomis ir Altajuje esančio Karakolo kaimo kraštotyros duomenimis, straipsnyje pateikiama naujų duomenų apie Bagdonių parapijos sentikių gyvenimą ir dalies bendruomenės narių likimus jiems išsikrausčius į Sibirą. Straipsnyje atskleidžiama aplinkinių požiūrio į Bagdonių sentikius dinamika, kintanti pagal tai, kokioje aplinkoje jie gyveno.
JAV lietuviškų organizacijų ženkleliai: laisvamaniai, tautininkai, liberalai, socialistai ir komunistai (XX a. pirmoji pusė)
Authors: Remecas Eduardas
Published: August 2024

XIX a. pab. – XX a. pr. į Jungtines Amerikos Valstijas atvykę lietuviai ėmė burtis į įvairias draugijas. Daugiausia tai buvo nedidelės katalikiškos šalpos draugijos, bet vėliau ėmė kurtis ir įvairūs susivienijimai, kurie steigė savo skyrius įvairiuose miestuose. Pagal pobūdį svarbiausios to meto organizacijos buvo skirstomos į dvi grupes: katalikiškas ir laisvamaniškas, kurios buvo vadinamos „pirmeiviškomis“ (progresyviomis arba pažangiomis). Laisvamaniškosioms buvo priskiriamos tautinės, liberalios, socialistinės, komunistinės ir tam tikra dalis kultūrinės krypties organizacijų. Daugeliui draugijų buvo įprasta savo organizacijų reklamai gamintis narių ženklelius. Šie simboliai organizacijoms turėjo skirtingą reikšmę: vienoms narių ženklelių pagaminimas buvo vienas pirmųjų darbų, o kitoms ženklelių klausimas buvo nelabai aktualus. Tai lėmė savos priežastys. Šiame straipsnyje pristatoma laisvamaniškų, tautinių, liberalių, socialistinių ir komunistinių bei dalies kultūrinės krypties organizacijų ženklelių kūrimo ir gamybos istorija.
Shedding Light on the Black Box of Rehabilitation: Differential Short- and Long-Term Effects of Multidisciplinary Multiple Sclerosis Rehabilitation
Authors: Trénel Philipp , Boesen Finn , Skjerbæk Anders Guldhammer , Petersen Thor , Rasmussen Peter Vestergaard , Nørgaard Michael
Published: August 2024

BACKGROUND:

The study of the effectiveness of multidisciplinary rehabilitation (MDR) and how the symptoms and needs of individuals with multiple sclerosis (MS) interplay with the diversity of MDR interventions is still a conundrum, often referred to as a black box.

METHODS:

We conducted a partial crossover randomized controlled trial with follow-ups at 1 (discharge), 6, and 12 months. Based on their rehabilitation goals, each patient was categorized into 1 of 5 main focus areas (MFAs) prior to admission: Resilience, Cognitive Function, Energy, Physical Function, and Personal Needs. The Functional Assessment of Multiple Sclerosis (FAMS) instrument scores were the primary outcome.

RESULTS:

MFA groups varied in age (P = .036), MS type (P = .002), Expanded Disability Status Scale score (P < .001), time since diagnosis (P = .002), and FAMS at baseline (P < .001), as well as in composition and quantity of MDR services. At discharge, significant FAMS improvements were found in all 5 MFA groups (FAMS change > 10.4, P < .05), but the affected subdimensions and persistence of improvements varied among MFA groups. At the 6-month follow-up, estimates of controlled differences in FAMS were 9.9 (P =.001), 5.6 (P = .196), 8.5 (P = .008), –1.4 (P = .548), and 17.9 (P = .012) for the Resilience, Cognitive Function, Energy, Physical Function, and Personal Needs groups, respectively.

CONCLUSIONS:

This study demonstrated that inpatient MDR improves functioning and health-related quality of life in people with MS; the type, degree, and persistence of the benefits are associated with a patient’s main focus area of rehabilitation, which signifies the importance of the goal-setting process in MDR.
Complementary opposing D2-MSNs and D1-MSNs dynamics during interval timing
Authors: Bruce R Austin , Weber Matthew A , Bova Alexandra S , Volkman Rachael A , Jacobs Casey E , Sivakumar Kartik , Stutt Hannah R , Kim Young-cho , Curtu Rodica , Narayanan Nandakumar S
Published: August 2024

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial striatal cognitive processing during interval timing, an elementary cognitive task that requires mice to estimate intervals of several seconds and involves working memory for temporal rules as well as attention to the passage of time. We harnessed optogenetic tagging to record from striatal D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) in the indirect pathway and from D1-dopamine receptor-expressing MSNs (D1-MSNs) in the direct pathway. We found that D2-MSNs and D1-MSNs exhibited distinct dynamics over temporal intervals as quantified by principal component analyses and trial-by-trial generalized linear models. MSN recordings helped construct and constrain a four-parameter drift-diffusion computational model. This model predicted that disrupting either D2-MSNs or D1-MSNs would increase interval timing response times and alter MSN firing. In line with this prediction, we found that optogenetic inhibition or pharmacological disruption of either D2-MSNs or D1-MSNs increased interval timing response times. Pharmacologically disrupting D2-MSNs or D1-MSNs also changed MSN dynamics and degraded trial-by-trial temporal decoding. Together, our findings demonstrate that D2-MSNs and D1-MSNs make complementary contributions to interval timing despite opposing dynamics, implying that striatal direct and indirect pathways work together to shape temporal control of action. These data provide novel insight into basal ganglia cognitive operations beyond movement and have implications for human striatal diseases and therapies targeting striatal pathways.
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
Authors: Aybar-Torres Alexandra , Saldarriaga Lennon A , Pham Ann T , Emtiazjoo Amir M , Sharma Ashish K , Bryant Andrew J , Jin Lei
Published: August 2024

The significance of STING (encoded by the
TMEM173
gene) in tissue inflammation and cancer immunotherapy has been increasingly recognized. Intriguingly, common human
TMEM173
alleles R71H-G230A-R293Q (
HAQ)
and G230A-R293Q (
AQ
) are carried by ∼60% of East Asians and ∼40% of Africans, respectively. Here, we examine the modulatory effects of
HAQ, AQ
alleles on STING-associated vasculopathy with onset in infancy (SAVI), an autosomal dominant, fatal inflammatory disease caused by gain-of-function human
STING
mutations. CD4 T cellpenia is evident in SAVI patients and mouse models. Using STING knock-in mice expressing common human
TMEM173
alleles
HAQ
,
AQ
, and
Q293
, we found that
HAQ, AQ
, and
Q293
splenocytes resist STING-mediated cell death
ex vivo,
establishing a critical role of STING residue 293 in cell death. The
HAQ/SAVI(N153S)
and
AQ/SAVI(N153S)
mice did not have CD4 T cellpenia. The
HAQ/SAVI(N153S), AQ/SAVI(N153S)
mice have more (∼10-fold, ∼20-fold, respectively) T-regs than
WT/SAVI(N153S)
mice. Remarkably, while they have comparable TBK1, IRF3, and NFκB activation as the
WT/SAVI
, the
AQ/SAVI
mice have no tissue inflammation, regular body weight, and normal lifespan. We propose that STING activation promotes tissue inflammation by depleting T-regs cells
in vivo
. Billions of modern humans have the dominant
HAQ, AQ
alleles. STING research and STING-targeting immunotherapy should consider
TMEM173
heterogeneity in humans.
A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams Syndrome
Authors: Zhao Xingsen , Sun Qihang , Shou Yikai , Chen Weijun , Wang Mengxuan , Qu Wenzheng , Huang Xiaoli , Li Ying , Wang Chao , Gu Yan , Ji Chai , Shu Qiang , Li Xuekun
Published: August 2024

Williams Syndrome (WS; OMIM#194050) is a rare disorder, which is caused by the microdeletion of one copy of 25-27 genes, and WS patients display diverse neuronal deficits. Although remarkable progresses have been achieved, the mechanisms for these distinct deficits are still largely unknown. Here, we have shown that neural progenitor cells (NPCs) in WS forebrain organoids display abnormal proliferation and differentiation capabilities, and synapse formation. Genes with altered expression are related to neuronal development and neurogenesis. Single cell RNA-seq (scRNA-seq) data analysis revealed 13 clusters in healthy control and WS organoids. WS organoids show an aberrant generation of excitatory neurons. Mechanistically, the expression of transthyretin (TTR) are remarkably decreased in WS forebrain organoids. We have found that GTF2IRD1 encoded by one WS associated gene
GTF2IRD1
binds to
TTR
promoter regions and regulates the expression of
TTR
. In addition, exogenous TTR can activate ERK signaling and rescue neurogenic deficits of WS forebrain organoids.
Gtf2ird1
deficient mice display similar neurodevelopmental deficits as observed in WS organoids. Collectively, our study reveals critical function of GTF2IRD1 in regulating neurodevelopment of WS forebrain organoids and mice through regulating TTR-ERK pathway.
RAG suppresses group 2 innate lymphoid cells
Authors: Ver Heul Aaron M , Mack Madison , Zamidar Lydia , Tamari Masato , Yang Ting-Lin , Trier Anna M , Kim Do-Hyun , Janzen-Meza Hannah , Van Dyken Steven J , Hsieh Chyi-Song , Karo Jenny M , Sun Joseph C , Kim Brian S
Published: August 2024

Antigen specificity is the central trait distinguishing adaptive from innate immune function. Assembly of antigen-specific T cell and B cell receptors occurs through V(D)J recombination mediated by the Recombinase Activating Gene endonucleases RAG1 and RAG2 (collectively called RAG). In the absence of RAG, mature T and B cells do not develop and thus RAG is critically associated with adaptive immune function. In addition to adaptive T helper 2 (Th2) cells, group 2 innate lymphoid cells (ILC2s) contribute to type 2 immune responses by producing cytokines like Interleukin-5 (IL-5) and IL-13. Although it has been reported that RAG expression modulates the function of innate natural killer (NK) cells, whether other innate immune cells such as ILC2s are affected by RAG remains unclear. We find that in RAG-deficient mice, ILC2 populations expand and produce increased IL-5 and IL-13 at steady state and contribute to increased inflammation in atopic dermatitis (AD)-like disease. Further, we show that RAG modulates ILC2 function in a cell-intrinsic manner independent of the absence or presence of adaptive T and B lymphocytes. Lastly, employing multiomic single cell analyses of RAG1 lineage-traced cells, we identify key transcriptional and epigenomic ILC2 functional programs that are suppressed by a history of RAG expression. Collectively, our data reveal a novel role for RAG in modulating innate type 2 immunity through suppression of ILC2s.
Systems genomics of salinity stress response in rice
Authors: Gupta Sonal , Groen Simon C , Zaidem Maricris L , Sajise Andres Godwin C , Calic Irina , Natividad Mignon A , McNally Kenneth L , Vergara Georgina V , Satija Rahul , Franks Steven J , Singh Rakesh K , Joly-Lopez Zoé , Purugganan Michael D
Published: August 2024

Populations can adapt to stressful environments through changes in gene expression. However, the role of gene regulation in mediating stress response and adaptation remains largely unexplored. Here, we use an integrative field dataset obtained from 780 plants of
Oryza sativa
ssp
. indica
(rice) grown in a field experiment under normal or moderate salt stress conditions to examine selection and evolution of gene expression variation under salinity stress conditions. We find that salinity stress induces increased selective pressure on gene expression. Further, we show that
trans
-eQTLs rather than
cis
-eQTLs are primarily associated with rice’s gene expression under salinity stress, potentially via a few master-regulators. Importantly, and contrary to the expectations, we find that
cis
-
trans
reinforcement is more common than
cis
-
trans
compensation which may be reflective of rice diversification subsequent to domestication. We further identify genetic fixation as the likely mechanism underlying this compensation/reinforcement. Additionally, we show that
cis
- and
trans
-eQTLs are under different selection regimes, giving us insights into the evolutionary dynamics of gene expression variation. By examining genomic, transcriptomic, and phenotypic variation across a rice population, we gain insights into the molecular and genetic landscape underlying adaptive salinity stress responses, which is relevant for other crops and other stresses.