bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute exposure to bisphenol A and cadmium causes changes in the morphology of gerbil ventral prostates and promotes alterations in androgen‐dependent proliferation and cell death
Authors: Colleta Simone J. , Antoniassi Julia Q. , Zanatelli Marianna , Santos Fernanda C.A. , Góes Rejane M. , Vilamaior Patricia S.L. , Taboga Sebastião R.
Published: November 2015

Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This study evaluated whether exposure to BPA and Cd during puberty can cause changes in the morphology, proliferation and cell death and androgen receptor (AR) immunostaining of the ventral prostates of normal and castrated male gerbils (Meriones unguiculatus), considering an acute exposure to the chemicals and evaluation after short (52d) and long (120d) periods. Generally, morphometric‐stereological results demonstrated that administration of BPA and Cd (individually or in combination) increased epithelial height, smooth muscle layer (SML) thickness and nuclear area and perimeter, and that these parameters were reduced in castrated animals. In addition, these groups showed important inflammatory processes but not prostate lesions. The proliferation/death rates of prostatic cells obtained by PCNA and TUNEL immunostaining demonstrated increased cell death in the 52d groups; in contrast, the gland acquired a more proliferative nature in the 120d groups. AR immunostaining showed that BPA and Cd compounds interact with ARs in different ways depending on the evaluated period and the hormonal profile of the animal. We conclude that BPA and cadmium are important agents in changing the morphology, proliferation and death of prostatic cells, in addition to interacting with ARs in different patterns. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 48–61, 2017.
The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long‐Term Report from a Single Institution
Authors: Baek Se‐Jin , Hur Hyuk , Min Byung‐Soh , Baik Seung‐Hyuk , Lee Kang‐Young , Kim Nam‐Kyu
Published: November 2015

Background

Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC.

Materials and methods

We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC.

Results

Most patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty‐one patients developed bone metastasis during the follow‐up period with median 10.1‐month interval. PET–CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal‐related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5‐year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04).

Conclusion

Bone metastasis in patients with CRC is extremely rare and shows poor prognosis.
ISDN2014_0016: REMOVED: Reproducibility in science: How video journals increase research validity and productivity
Authors: Henderson Kira M.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0018: REMOVED: The relationship between Chinese high school students' academic stress and depressive symptoms: The 5‐HTTLPR gene polymorphism as a moderator
Authors: Liu Yangyang
Published: November 2015

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This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0020: REMOVED: Glycoconjugates distribution during developing mouse Spinal Cord motor organizer
Authors: Fazel Alireza , Vojoudi Elham , Ebrahimi Vahid , Ebrahimzadeh Alireza
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0023: REMOVED: Mindfulness meditation with incarcerated youth: A randomized controlled trial informed by neuropsychosocial theories of adolescence
Authors: Evans‐Chase Michelle
Published: November 2015

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This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0024: REMOVED: Risk‐taking and self‐regulation: A systematic review of the analysis of delinquency outcomes in the juvenile justice intervention literature 1996–2009
Authors: Evans‐Chase Michelle , Kim Minseop , Zhou Huiquan
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0030: REMOVED: Age‐dependent regulation of GLT‐1/EAAT2 expression during traumatic brain injury: A coherent and mutual role for NF‐κB and N‐myc
Authors: Gupta R.K. , Prasad S.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0046: REMOVED: Assessment of examination stress in young adults
Authors: Pranita A. , Kharche J.S. , Balsubramanian B. , Joshi A.R.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0050: REMOVED: Apocyanin, a microglia PHOX inhibitor prevents dopaminergic degeneration in Lipopolysaccharide induced Parkinson's disease model
Authors: Sharma Neha , Nehru Bimla
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0052: REMOVED: The effects of melodic intonation therapy on MLU in 7–10‐year Persian non‐verbal autistic, male children
Authors: Ferdosi Neda , Ashayeri Hassan , Modarresi Yahya , Rovshan Belghis
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0063: REMOVED: Pathological sharp waves and hyperexcitability in a mouse model of Fetal Alcohol Spectrum Disorder (FASD)
Authors: Krawczyk Micahl , Ramani Meera , Mylvaganam Shanthini , Carlen Peter L.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0071: REMOVED: Insulin protects SH‐SY5Y neuroblastoma cells against 6‐OHDA induced toxicity
Authors: Maryam Moosavi , Esmat Amiri , Rasoul Ghasemi , Asadollah Zarifkar
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0074: REMOVED: Effects of adenosine A2a receptor agonist and antagonist on hippocampal nuclear factor‐kB expression preceded by MDMA toxicity
Authors: Mehdizadeh Mehdi , Kermanian Fatemeh , Soleimani Mansooreh , Ebrahimzadeh Alireza , Haghir Hossein
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0106: REMOVED: Age‐of‐script‐acquisition effects in the default‐mode network
Authors: Gilead M. , Liberman N. , Maril A.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0110: REMOVED: Role of retinoic acid in chick tectal laminar development
Authors: Kukreja S. , Sen J.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0111: REMOVED: Salivary biomarkers in Alzheimer's disease
Authors: Rai Balwant
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0113: REMOVED: Stromal vascular fraction in peripheral nerve regeneration
Authors: Gallyamov A.R. , Masgutov R.F. , Rizvanov A.A. , Salafutdinov I.I. , Ahtyamov I.F. , Bogov A.A. , Bogov A.A.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0123: REMOVED: Neonatal clomipramine decreases adult hippocampal cell proliferation and impairs spatial navigation in adult male Wistar rats
Authors: Bhagya V. , Mahati K. , Kundu Sankhanava , Shankaranarayana Rao B.S. , Raju T.R.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0131: REMOVED: Gene therapy of peripheral nerve injuries: First clinical results
Authors: Bogov A.A. , Masgutov R.F. , Risvanov A.A. , Salafutdinov I.I. , Gallamov A.R. , Ahtyamov I.F. , Bogov A.A.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0146: REMOVED: MeCP2‐chromatin binding dynamics shows a direct genotype–phenotype correlation in males with single amino acid substitutions
Authors: Sheikh Taimoor , Faghfoury Hannah , Silver Josh , Vincent John B.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0172: REMOVED: Developmental and behavioural abnormalities in mice with targeted mutations in Dlx enhancer sequences
Authors: Darbandi Siavash Fazel , Esau Crystal , Poitras Luc , Lesage‐Pelletier Cindy , Yu Man , Hatch Gary , Ekker Marc
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0195: REMOVED: Developmental changes of glycogen synthase kinase‐3β contribute to age‐dependent long‐term depression in prefrontal cortex in both normal animal and a schizophrenia model
Authors: Xing Bo , Gao Wen‐Jun
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0198: REMOVED: NGF activation of the integrative nuclear FGFR1 signaling (INFS) mediates gene activation and cell differentiation
Authors: Birkaya B. , Lee Y.‐W. , Stachowiak E.K. , Terranova C. , Aletta J.M. , Stachowiak M.K.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0216: REMOVED: Posterior reversible encephalopathy syndrome with atypicalregions in eclamptic patients: A challenge for radiologists
Authors: Amin M.F. , Abd El Gawad E.A. , El Ameen N.F.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0237: REMOVED: Silymarin attenuates neurotoxicity, oxidative stress and antioxidant enzymes perturbations induced by lead in rat brain
Authors: El‐Demerdash Fatma M. , Taher Hoda M. , Abbassy Moustafa S.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0258: REMOVED: Sex differences and laterality of insulin receptor distribution in developing rat hippocampus – An immunohistochemical study
Authors: Hami Javad , Kheradmand Hamed , Haghir Hossein
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0262: REMOVED: Prenatal stress increased Snk Polo‐like kinase 2 and the SCF β‐TrCP ubiquitin ligase in the hippocampus of the adult offspring
Authors: Chutabhakdikul Naunchan , Surakul Pornprom
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0273: REMOVED: The origin of amyloid plaques
Authors: Salber Dagmar
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0277: REMOVED: Prenatal alcohol exposure enhances alcohol withdrawal seizure susceptibility in adulthood
Authors: N'Gouemo Prosper
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0278: REMOVED: Peripheral blood markers of homocysteine, paraoxonase1 (PON1) activity and oxidative stress in autism
Authors: Balachandar V. , Sureshkumar S. , Mohanadevi S. , Balamuralikrishnan B. , Sankar K. , Arun M. , Dharwadkar S.N. , Sasikala K.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0281: REMOVED: Axon elongation is regulated by adenosine A2A receptors
Authors: Ribeiro Filipa F. , Santos Telma , Silva Rui , Sousa Mónica , Sebastião Ana M.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0294: REMOVED: Insulin resistance and obesity in childhood and long term consequences during aging
Authors: Pasinetti Giulio Maria
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0296: REMOVED: The relationship between motor lateralization and executive function
Authors: Mills K.J. , Gibb R.L. , MacLean J.N. , Netelenbos N. , Gonzalez C.L.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0298: REMOVED: Cerebral atrophy is linked to clinical severity and worsens with aging in patients with Pelizaeus–Merzbacher disease and Spastic Paraplegia type 2
Authors: Sarret C. , Lemaire J.J. , Sontheimer A. , Coste J. , Pereira B. , Feschet F. , Roche B. , Renou J.P. , Boespflug‐Tanguy O.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0322: REMOVED: Identification of novel genetic causes of Rett syndrome‐like phenotypes by whole exome sequencing
Authors: Lopes Fátima , Barbosa Mafalda , Temudo Teresa , de Sá Joaquim , Dias Ana Isabel , Oliveira Guiomar , Cabral Pedro , Calado Eulália , Cruz Isabel Fineza , Soares Gabriela , Vieira José Pedro , Venâncio Maria Margarida , Oliveira Renata , Jonasson Inger , Ameur Adam , Pinto Dalila , Ulf Gyllensten  , Maciel Patrícia
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0329: REMOVED: MnTM‐4‐PyP protects cortical neurons against oxidative stress via induction of cellular antioxidant responses
Authors: Cheng Kuoyuan , Guo Fei , Lu Jiaqi , Cao Yuanzhao , Xia Qing
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0336: REMOVED: Increased neurogenesis in the rat hippocampus and dentate gyrus after spreading depression
Authors: Lotfinia Mahmoud
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0337: REMOVED: Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development
Authors: Zander Mark A. , Burns Sarah E. , Yang Guang , Kaplan David R. , Miller Freda D.
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0348: REMOVED: Enriched environment prevents hypobaric hypoxia induced memory impairment through modulating hippocampal synaptic strength and plasticity
Authors: Jain Vishal , Prasad Dipti , Ilavazhagan G. , Singh Shashi Bala
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0385: REMOVED: A bivariate Genome Wide Association Study (GWAS) of depressive symptoms and lipid levels has identified pleiotropic gene loci
Authors: Amare Azmeraw T. , Nigatu Yeshambel T. , Hsu Yi‐Hsiang , Lahti Jari , Alizadeh Behrooz Z. , Snieder Harold ,   Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) depression working Group Global Lipids Genetics Consortium
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0386: REMOVED: Fluoxetine attenuates hippocampal neurogenesis deficits and DNA hypermethylation of CREB‐BDNF pathway related to S‐adenosyl methionine
Authors: Zhang Xiang Rong , Wang Ying Xin , Zhang Zhi Jun
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0390: REMOVED: Dab2IP regulates neuronal migration and Rap1 activity in the developing cortex
Authors: Qiao Shuhong , Salami Farimah , Homayouni Ramin
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0398: REMOVED: Corpus callosum abnormalities in medication‐naïve adult patients with obsessive compulsive disorder
Authors: Jose Dania , Narayanaswamy Janardhanan C. , Agarwal Sri Mahavir , Kalmady Sunil , Venkatasubramanian Ganesan , Reddy Y.C. Janardhan
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)

This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
The Past is a Foreign Country – Revisited
Authors: Lowenthal David
Published: November 2015

The past remains essential - and inescapable. A quarter-century after the publication of his classic account of man's attitudes to his past, David Lowenthal revisits how we celebrate, expunge, contest and domesticate the past to serve present needs. He shows how nostalgia and heritage now pervade every facet of public and popular culture. History embraces nature and the cosmos as well as humanity. The past is seen and touched and tasted and smelt as well as heard and read about. Empathy, re-enactment, memory and commemoration overwhelm traditional history. A unified past once certified by experts and reliant on written texts has become a fragmented, contested history forged by us all. New insights into history and memory, bias and objectivity, artefacts and monuments, identity and authenticity, and remorse and contrition, make this book once again the essential guide to the past that we inherit, reshape and bequeath to the future.
Heidegger and Politics
Authors: Duff Alexander S.
Published: November 2015

In this fresh interpretation of Heidegger, Alexander Duff explains Heidegger's perplexing and highly varied political influence. Heidegger and Politics argues that Heidegger's political import is forecast by fundamental ambiguities about the status of politics in his thought. Duff explores how in Being and Time as well as earlier and later works, Heidegger analyzes 'everyday' human existence as both irretrievably banal but also supplying our only tenuous path to the deepest questions about human life. Heidegger thus points to two irreconcilable attitudes toward politics: either a total and purifying revolution must usher in an authentic communal existence, or else we must await a future deliverance from the present dispensation of Being. Neither attitude is conducive to moderate politics, and so Heidegger's influence tends towards extremism of one form or another, modified only by explicit departures from his thought.
Milton's Visual Imagination
Authors: Dobranski Stephen B.
Published: November 2015

Critics have traditionally found fault with the descriptions and images in John Milton's poetry and thought of him as an author who wrote for the ear more than the eye. In Milton's Visual Imagination, Stephen B. Dobranski proposes that, on the contrary, Milton enriches his biblical source text with acute and sometimes astonishing visual details. He contends that Milton's imagery - traditionally disparaged by critics - advances the epic's narrative while expressing the author's heterodox beliefs. In particular, Milton exploits the meaning of objects and gestures to overcome the inherent difficulty of his subject and to accommodate seventeenth-century readers. Bringing together Milton's material philosophy with an analysis of both his poetic tradition and cultural circumstances, this book is a major contribution to our understanding of early modern visual culture as well as of Milton's epic.
The Concept of Nature
Authors: Whitehead Alfred North
Published: November 2015

When The Concept of Nature by Alfred North Whitehead was first published in 1920 it was declared to be one of the most important works on the relation between philosophy and science for many years, and several generations later it continues to deserve careful attention. Whitehead explores the fundamental problems of substance, space and time, and offers a criticism of Einstein's method of interpreting results while developing his own well-known theory of the four-dimensional 'space-time manifold'. With a specially commissioned new preface written by Michael Hampe, this book is presented in a fresh series livery for the twenty-first century for a new generation of readers.
Art and its Objects
Authors: Wollheim Richard
Published: November 2015

Richard Wollheim's classic reflection on art considers central questions regarding expression, representation, style, the significance of the artist's intention and the essentially historical nature of art. Presented in a fresh series livery for the twenty-first century, with a specially commissioned Preface written by Richard Eldridge, illuminating its continuing importance and relevance to philosophical enquiry, Art and its Objects continues to be a perceptive and engaging introduction to the questions and philosophical issues raised by works of art and the part they play in our culture and society. Wollheim's insights into theories of art, criticism, perception and the nature of aesthetic value make this one of the most influential works on aesthetics of the twentieth century.
A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma
Authors: Kang JeenJoo S. , Dervan Peter B.
Published: November 2015

Means to cause an immunogenic cell death could lead to significant insight into how cancer escapes immune control. In this study, we screened a library of five pyrrole–imidazole polyamides coding for different DNA sequences in a model of B-cell lymphoma for the upregulation of surface calreticulin, a pro-phagocytosis signal implicated in immunogenic cell death. We found that hairpin polyamide 1 triggers the release of the damage-associated molecular patterns calreticulin, ATP and HMGB1 in a slow necrotic-type cell death. Consistent with this signaling, we observed an increase in the rate of phagocytosis by macrophages after the cancer cells were exposed to polyamide 1. The DNA sequence preference of polyamide 1 is 5′-WGGGTW-3′ (where W = A/T), indicated by the pairing rules and confirmed by the Bind-n-Seq method. The close correspondence of this sequence with the telomere-repeat sequence suggests a potential mechanism of action through ligand binding at the telomere. This study reveals a chemical means to trigger an inflammatory necrotic cell death in cancer cells.
Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor
Authors: Kappel Kalli , Miao Yinglong , McCammon J. Andrew
Published: November 2015

Elucidating the detailed process of ligand binding to a receptor is pharmaceutically important for identifying druggable binding sites. With the ability to provide atomistic detail, computational methods are well poised to study these processes. Here, accelerated molecular dynamics (aMD) is proposed to simulate processes of ligand binding to a G-protein-coupled receptor (GPCR), in this case the M3 muscarinic receptor, which is a target for treating many human diseases, including cancer, diabetes and obesity. Long-timescale aMD simulations were performed to observe the binding of three chemically diverse ligand molecules: antagonist tiotropium (TTP), partial agonist arecoline (ARc) and full agonist acetylcholine (ACh). In comparison with earlier microsecond-timescale conventional MD simulations, aMD greatly accelerated the binding of ACh to the receptor orthosteric ligand-binding site and the binding of TTP to an extracellular vestibule. Further aMD simulations also captured binding of ARc to the receptor orthosteric site. Additionally, all three ligands were observed to bind in the extracellular vestibule during their binding pathways, suggesting that it is a metastable binding site. This study demonstrates the applicability of aMD to protein–ligand binding, especially the drug recognition of GPCRs.
Chemical materials and their regulation of the movement of molecules
Authors: Langer Robert
Published: November 2015

Materials chemistry has been fundamental to the enormous field that encompasses the delivery of molecules both to desired sites and/or at desired rates and durations. The field encompasses the delivery of molecules including fertilizers, pesticides, herbicides, food ingredients, fragrances and biopharmaceuticals. A personal perspective is provided on our early work in this field that has enabled the controlled release of ionic substances and macromolecules. Also discussed are new paradigms in creating biomaterials for human use, the non-invasive delivery of molecules through the skin and lungs, the development of intelligent delivery systems and extensions to nanomedicine. With the advent of potentially newer biopharmaceutics such as siRNA, mRNA and gene editing approaches and their use being limited by delivery, future research in this field may be more critical than ever before.
Scattering of a scalar time-harmonic wave by a penetrable obstacle with a thin layer
Authors: BOUTARENE K. E. , COCQUET P.-H.
Published: November 2015

This work looks at the asymptotic behaviour of the solution to the Helmholtz equation in a penetrable domain of$\mathbb{R}$3with a thin layer of thickness δ which tends to 0. We use the method of multi-scale expansion to derive and justify an asymptotic expansion of the solution with respect to the thickness δ up to any order. We then provide approximate transmission conditions of order two defined on an interface located inside the thin layer, with accuracy up toO(δ2), which allow one to take into account the influence of the thin layer.
Einflussfaktoren auf die Einstellung von SchülerInnen gegenüber Peers mit unterschiedlichen Behinderungen
Authors: Schwab Susanne
Published: November 2015

Zusammenfassung. Die vorliegende Studie untersucht die Einflussfaktoren der Einstellung von SchülerInnen gegenüber ihren Peers mit unterschiedlichen Behinderungen. Insgesamt haben 1115 SchülerInnen der vierten und siebten Schulstufe an der Erhebung teilgenommen. Zur Erfassung der Einstellung wurde eine Kurzfassung der CATCH Skala ( Rosenbaum, Armstrong & King, 1986 ) verwendet, wobei die Einstellung gegenüber vier unterschiedlichen Behinderungsarten (körperliche Behinderung, Lernbehinderung, geistige Behinderung und Verhaltensauffälligkeit) erfasst wurde. Zu Beginn wurde die psychometrische Eignung der Skala für SchülerInnen mit und ohne sonderpädagogischem Förderbedarf bestätigt. Insgesamt zeigte sich eine neutrale bis vorsichtig positive Einstellung der SchülerInnen gegenüber Peers mit Behinderung. Diese ist in Bezug auf Peers mit körperlicher Behinderung oder Lernbehinderung positiver als gegenüber Peers mit geistiger Behinderung oder Verhaltensauffälligkeit. Des Weiteren wurde gezeigt, dass die Varianzaufklärung für die Einstellung gegenüber ihren Peers mit Behinderung sowohl Anteile auf der individuellen als auch (in sehr geringem Maße) Anteile auf der klassenspezifischen Ebene aufweist. Erwartungsgemäß besitzen Mädchen eine positivere Einstellung als Jungen.
Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53
Authors: Park E K , Lee J C , Park J W , Bang S Y , Yi S A , Kim B K , Park J H , Kwon S H , You J S , Nam S W , Cho E J , Han J W
Published: November 2015

Novel therapeutic strategies are needed to overcome cancer recurrence, metastasis, and resistance to chemo- and radiotherapy. Cancer stem cells (CSCs) are major contributors to the malignant transformation of cells due to their capacity for self-renewal. Although various CSC markers have been identified in several types of tumors, they are primarily used as cancer-prediction markers and for the isolation of CSC populations. CD133, one of the best-characterized CSC markers in distinct solid tumor types, was shown to be correlated with CSC tumor-initiating capacity; however, the regulation of CD133 expression and its function in cancer are poorly understood. Here, we show that CD133 expression is negatively regulated by direct binding of the p53 tumor suppressor protein to a noncanonical p53-binding sequence in the CD133 promoter. Binding of p53 recruits Histone Deacetylase 1 (HDAC1) to the CD133 promoter and subsequently suppresses CD133 expression by reducing histone H3 acetylation. Furthermore, CD133 depletion suppresses tumor cell proliferation, colony formation, and the expression of core stemness transcription factors including NANOG, octamer-binding transcription factor 4 (OCT4), SOX2, and c-MYC. Critically, the anti-proliferative effects of p53 are antagonized by rescue of CD133 expression in a p53 overexpressing cell line, indicating that the tumor suppressive activity of p53 might be mediated by CD133 suppression. Taken together, our results suggest that p53-mediated transcriptional regulation of CD133 is a key underlying mechanism for controlling the growth and tumor-initiating capacity of CSCs and provide a novel perspective on targeting CSCs for cancer therapy.
L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer’s disease via activating dopamine D1 receptor/PKA signaling pathway
Authors: Hao J-R , Sun N , Lei L , Li X-Y , Yao B , Sun K , Hu R , Zhang X , Shi X-D , Gao C
Published: November 2015

It is accepted that amyloid β-derived diffusible ligands (ADDLs) have a prominent role in triggering the early cognitive deficits that constitute Alzheimer’s disease (AD). However, there is still no effective treatment for preventing or reversing the progression of the disease. Targeting α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor trafficking and its regulation is a new strategy for AD early treatment. Here we investigate the effect and mechanism of L-Stepholidine (L-SPD), which elicits dopamine D1-type receptor agonistic activity, while acting as D2-type receptor antagonist on cognition and synaptic plasticity in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic (APP/PS1) mice, and hippocampal cultures or slices treated with ADDLs. L-SPD could improve the hippocampus-dependent memory, surface expression of glutamate receptor A (GluA1)-containing AMPA receptors and spine density in hippocampus of APP/PS1 transgenic mice. L-SPD not only rescued decreased phosphorylation and surface expression of GluA1 in hippocampal cultures but also protected the long-term potentiation in hippocampal slices induced by ADDLs. Protein kinase A (PKA) agonist Sp-cAMPS or D1-type receptor agonist SKF81297 had similar effects, whereas PKA antagonist Rp-cAMPS or D1-type receptor antagonist SCH23390 abolished the effect of L-SPD on GluA1 trafficking. This was mediated mainly by PKA, which could phosphorylate serine residue at 845 of the GluA1. L-SPD may be explored as a potential therapeutic drug for AD through a mechanism that improves AMPA receptor trafficking and synaptic plasticity via activating D1/PKA signaling pathway.
The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury
Authors: Liu H , Li W , Rose M E , Hickey R W , Chen J , Uechi G T , Balasubramani M , Day B W , Patel K V , Graham S H
Published: November 2015

Cyclopentenone prostaglandins (CyPGs), such as 15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2), are reactive prostaglandin metabolites exerting a variety of biological effects. CyPGs are produced in ischemic brain and disrupt the ubiquitin-proteasome system (UPS). Ubiquitin-C-terminal hydrolase L1 (UCH-L1) is a brain-specific deubiquitinating enzyme that has been linked to neurodegenerative diseases. Using tandem mass spectrometry (MS) analyses, we found that the C152 site of UCH-L1 is adducted by CyPGs. Mutation of C152 to alanine (C152A) inhibited CyPG modification and conserved recombinant UCH-L1 protein hydrolase activity after 15dPGJ2 treatment. A knock-in (KI) mouse expressing the UCH-L1 C152A mutation was constructed with the bacterial artificial chromosome (BAC) technique. Brain expression and distribution of UCH-L1 in the KI mouse was similar to that of wild type (WT) as determined by western blotting. Primary cortical neurons derived from KI mice were resistant to 15dPGJ2 cytotoxicity compared with neurons from WT mice as detected by the WST-1 cell viability assay and caspase-3 and poly ADP ribose polymerase (PARP) cleavage. This protective effect was accompanied with significantly less ubiquitinated protein accumulation and aggregation as well as less UCH-L1 aggregation in C152A KI primary neurons after 15dPGJ2 treatment. Additionally, 15dPGJ2-induced axonal injury was also significantly attenuated in KI neurons as compared with WT. Taken together, these studies indicate that UCH-L1 function is important in hypoxic neuronal death, and the C152 site of UCH-L1 has a significant role in neuronal survival after hypoxic/ischemic injury.