bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of pain catastrophizing and anxiety in patients with dyspareunia and healthy women: a cross-sectional study
Authors: Mohammadzadeh Zahra ,   Reproductive Health and Midwifery Department, Tehran University of Medical Sciences, Tehran, Iran,   Social Security Organization, East Azerbaijan Treatment Management, Tabriz, Iran, Khakbazan Zohreh ,   Reproductive Health and Midwifery Department, Tehran University of Medical Sciences, Tehran, Iran, Rad Maryam ,   Oral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran, Farnam Farnaz ,   Reproductive Health and Midwifery Department, Tehran University of Medical Sciences, Tehran, Iran,   * Corresponding Author: Farnaz Farnam, Reproductive Health and Midwifery Department, Tehran University of Medical Sciences, Tehran, Iran. E-mail: Fz.farnam@gmail.com; f-farnam@sina.tums.ac.ir
Published: May 2023

Despite the prominent role of cognitive-affective variables, such as pain catastrophizing and anxiety in chronic pain, little is known about their relationship with dyspareunia. This study compared pain-catastrophizing and anxiety in reproductive-aged women with and without dyspareunia. A controlled cross-sectional study was conducted on 398 married women in Iran selected by convenience sampling. Sampling was performed both online and in person. Data were collected using a checklist designed for the study, including background characteristics, self-reported dyspareunia, and two standard questionnaires: the Pain Catastrophizing Scale (PCS) and the Spielberger State-Trait Anxiety Inventory-6 (STAI-6). Results showed that 49.5% of the women reported dyspareunia in the previous six months, with a reduced figure of 42% and 31% when using more specific criteria for dyspareunia. Women with dyspareunia had significantly higher scores for pain catastrophizing and anxiety than the control group without dyspareunia. Pain-catastrophizing was associated with aversion to genital contact and body image dissatisfaction. Anxiety was correlated with age, marriage duration, and sexual abuse. Managing anxiety and catastrophizing thoughts may help dyspareunia patients better cope with pain.
Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
Authors: Stoian Marilena ,   Department of Internal Medicine, Dr. Ion Cantacuzino Clinical Hospital, Bucharest, Romania,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   * Corresponding Author: Marilena Stoian, Department of Internal Medicine, Dr. Ion Cantacuzino Clinical Hospital, Bucharest, Romania. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: marilenastoian@yahoo.com, Procopiescu Bianca ,   Department of Internal Medicine, Dr. Ion Cantacuzino Clinical Hospital, Bucharest, Romania, Șeitan Silviu ,   Department of Internal Medicine, Dr. Ion Cantacuzino Clinical Hospital, Bucharest, Romania, Scarlat Gabriel ,   Department of Internal Medicine, Dr. Ion Cantacuzino Clinical Hospital, Bucharest, Romania
Published: May 2023

Coronavirus disease 2019 (COVID-19) is currently considered a complex systemic infectious and inflammatory disease, determined by the infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the cause of one of the most important epidemiological phenomena in the last century – the COVID-19 pandemic. This infectious-inflammatory disease may generate a wide range of clinical manifestations and biological modifications, explained by the ubiquitous nature of the SARS-CoV-2 receptors, represented by the angiotensin-converting enzyme-2 (ACE-2), and by the host’s violent immune and proinflammatory reaction to the viral infection. These manifestations include immunological disturbances, which, according to certain clinical findings, may persist post-infection, in the form of a presumed systemic inflammatory entity, defined by several clinical concepts with a common pathological significance: post-COVID-19 multisystem (or systemic) inflammatory syndrome, post-COVID syndrome or long-COVID. Although the pathophysiological mechanisms of the post-COVID-19 syndrome are elusive at the present moment, there are currently several studies that describe a systemic inflammatory or autoimmune phenomenon following the remission of the COVID-19 infection in some patients, which suggests the existence of molecular and cellular immune abnormalities, most probably due to the host’s initial violent immune response to the viral infection, in the form of three overlapping entities: secondary hemophagocytic lymph histiocytosis (HLH), macrophage activation syndrome (MAS) and cytokine release syndrome (CRS). Thus, this is reminiscent of different classic autoimmune diseases, in which various infections are risk factors in developing the autoimmune process.
Genetic screening of PLA1/PLA2 polymorphous marker of integrin beta 3 (ITGB3) GP IIIA gene in adolescent girls with puberty menorrhagia
Authors: Tsysar Yuliia Vasylivna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine,   * Corresponding Author: Yuliia Vasylivna Tsysar, Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine. E-mail: tsysar.yuliia@bsmu.edu.ua, Andriiets Oksana Anatolievna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Dubyk Liudmyla Vasylivna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Dyak Kristina Viktorivna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Radu Raluca Mihaela ,   Materno-Fetal Assistance Excellence Unit, Polizu Clinical Hospital, Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania
Published: May 2023

Puberty menorrhagia is one of the urgent problems of modern reproductive medicine. The study aimed to investigate the relationship between polymorphism of the GP IIIa (PLA1/PLA2) gene and improve the diagnosis of puberty menorrhagia in girls with thyroid gland pathology. Ninety-seven girls at puberty age were divided into three groups: group 1 (main) – girls with puberty menorrhagia and thyroid gland pathology (30 individuals), group 2 (comparison) – 40 girls with puberty menorrhagia, group 3 (control) – 27 practically healthy girls. Polymorphism of the GP IIIa (PLA1/PLA2) gene was studied by isolating genomic DNA from peripheral blood leukocytes, followed by amplification with a polymerase chain reaction. Results showed that mutation in the 17th chromosome of q21.32 of the GP IIIa gene occurred in 8.6% of cases among adolescents with menorrhagia, in contrast to the control group, where it was not observed at all. The A1A1-genotype occurred by 11.7% (X2=4.01, p=0.041) more often in adolescents with menorrhagia than in girls with concomitant thyroid gland pathology and by 15.0% (X2=4.54, p=0.033) more often than in the control group. It was also found that the presence of the A1A2-genotype unreliably reduced the chances of uterine bleeding in adolescent girls by 1.45 times (OR=2.12) and was a protective factor in the puberty menorrhagia occurrence (OR=0.47). It may be concluded that the identification of a hereditary factor of the reproductive system diseases of adolescent girls fundamentally changes the point of view on the tactics of disease management and subsequent therapy.
Quality assessment of shoulder MRI according to practice parameters of American College of Radiology: A multi-center study in Jordan
Authors: Ayasrah Mohammad ,   Department of Allied Medical Sciences, Jordan University of Science and Technology, Ramtha, Jordan,   * Corresponding Author: Mohammad Ayasrah, Department of Allied Medical Sciences, Jordan University of Science and Technology, Ramtha, Jordan. E-mail: maayasrah@just.edu.jo, Qtaish Izzeddin ,   Radiology and Interventional Radiology Department, Faculty of Medicine, Jordan University of Science and Technology, Ramtha, Jordan
Published: May 2023

Magnetic resonance imaging (MRI) is essential for assessing shoulder conditions. This study aimed to evaluate current shoulder MRI practices in Jordan, including technical parameter patterns, and determine if they adhere to the American College of Radiology (ACR) guidelines. The retrospective analysis included data from 48 eligible participants from 13 MRI centers in March 2021. Descriptive and correlation data analysis were performed using IBM SPSS statistics version_20 and Excel 2013. Most MRI centers (50%) were private outpatient clinics with closed MRI machines above 1 Tesla. Most participants (62.5%) were male, and shoulder pain (47.9%) was the main clinical indication. Most shoulder orientations (68.7%, 33/48) were right shoulders, and the coronal MRI planes (43%, 121/280) were the most common. The alignment percentage for the axial plane was 100%, but MRI artifacts of the shoulder were present in 8.2% of cases (23/280). Dark fluid T1-W coronal sequence was not conducted in 25% of the cases. The percentage of the field view (FOV) within ACR recommendations was 45% (126/281), and slice thickness parameters were 96% (269/281). The recommended pixel area for all sequences was 47.9% (134/280), encompassing all axial, sagittal oblique, and coronal planes. However, crucial parameters, such as FOV and slice thickness, were inadequate and did not meet the ACR guidelines, resulting in suboptimal image quality of shoulder MRI. To improve MRI image quality, it is recommended that MRI technologists receive ongoing education and training on appropriate MRI image parameters.
Efficacy of Aflibercept as initial treatment for neovascular age-related macular degeneration in an Iraqi patient sample
Authors: Hussein Zaid Rajab ,   Department of Ophthalmology, Ibn Al-Haithem Teaching Eye Hospital, Baghdad, Iraq,   * Corresponding Author: Zaid Rajab Hussein, Department of Ophthalmology, Ibn Al-Haithem Teaching Eye Hospital, Baghdad, Iraq. E-mail: zaid_alalusi@yahoo.com, Omar Sufyan Khalid ,   Department of Ophthalmology, Ibn Al-Haithem Teaching Eye Hospital, Baghdad, Iraq, Alkazraji Rasha Abdulelah Mustafa ,   Department of Pharmacology, College of Medicine, University of Baghdad, Baghdad, Iraq, Alsamarrai Ahmed Nezar ,   Department of Ophthalmology, Ibn Al-Haithem Teaching Eye Hospital, Baghdad, Iraq, Alrubaye Hayder Sabah ,   Department of Ophthalmology, Ibn Al-Haithem Teaching Eye Hospital, Baghdad, Iraq, Al-hussaniy Hany Akeel ,   Department of Pharmacology, College of Medicine, University of Baghdad, Baghdad, Iraq,   Dr. Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq,   Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq,   Hany Akeel Al-hussaniy, Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq. E-mail: hany_akeel2000@yahoo.com
Published: May 2023

Age-related macular degeneration (AMD) is a progressive degenerative eye disorder that primarily affects individuals over 50. It causes gradual loss of central vision and can lead to irreversible severe visual loss if left untreated. AMD is a leading cause of blindness in the developed world. This study aimed to investigate the effects of a loading dosage of intravitreal Aflibercept on functional and morphological responses in neovascular AMD, considering demographic characteristics and the link between AMD-related retinal symptoms at presentations. A prospective interventional study was conducted from November 2021 to September 2022 on a sample of Iraqi patients with neovascular AMD who had active choroidal neovascularization (CNV) lesions confirmed by OCT-A and received intravitreal Aflibercept 2mg injection as initial therapy (3 loading doses). Best-corrected visual acuity (BCVA) was used to measure functional responses, and central macular thickness (CMT) and maximum area of the retinal thickness (MART) (by SD-OCT) were used to measure morphological responses. The study included 48 patients (57 eyes) with active neovascular AMD. The mean difference of BCVA in log MAR (0.2 ± 0.7) significantly improved from 1.3±0.7 at baseline to 1.1±0.8 after loading Aflibercept (P=0.034). The mean difference in CMT 113.6 ± 125.9 was statistically significant (P<0.0001). Also, the mean change in MART significantly decreased from 444.2 ± 127.1 µm at baseline to 348.7±74.5 µm (p < 0.0001) after loading Aflibercept. This study demonstrated that Aflibercept is a functionally and anatomically successful treatment for neovascular AMD.
Practices, attitudes and knowledge of midwives and nurses regarding gestational diabetes and pregnancy-induced hypertension
Authors: Stan Daniela ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   The Order of Nurses, Midwives and Medical Assistants in Romania, Bucharest, Romania, Dobre Claudia Elena ,   The Order of Nurses, Midwives and Medical Assistants in Romania, Bucharest, Romania,   Department of General and Specific Nursing, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   * Corresponding Author: Claudia Elena Dobre, Department of General and Specific Nursing, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: claudia.dobre@umfcd.ro, Mazilu Doina Carmen ,   The Order of Nurses, Midwives and Medical Assistants in Romania, Bucharest, Romania,   Department of General and Specific Nursing, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Brătilă Elvira ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: May 2023

Midwives (M) and obstetric nurses (ON) play a critical role in providing healthcare for pregnant patients at all stages of pregnancy, and ongoing training and education are essential to ensure the best outcomes. This longitudinal quantitative research study aimed to assess the impact of an educational program on the knowledge, attitudes, and practices of 125 midwives and obstetric nurses regarding care for patients with gestational diabetes and pregnancy-induced hypertension. The original questionnaire consisted of 56 items grouped into 3 subscales assessing knowledge (15 items), attitudes (18 items), and practices (23 items). The questionnaire was administered at three distinct intervals during the educational program: pre-test, post-test, and follow-up at three months. The data were analyzed using ANOVA and Pearson correlation coefficients to determine the significance of the differences between the 3 moments of the administration of the questionnaire. There was a significant increase in the level of knowledge, attitudes, and practices of midwives and obstetric nurses following the training module, which was sustained at 3 months after completion compared to pre-training. The comparative analysis of the total scores for every 3 sets of items revealed the positive impact of the educational program on the level of knowledge, attitudes, and practices of midwives and obstetric nurses.
HUMAN TRACKING OBJECTS IN DARK SITUATIONS BASED ON THERMAL USING SUPPORT VECTOR MACHINES, L1 TRACKER USING ACCELERATED PROXIMAL GRADIENT APPROACH, AND KERNELIZED CORRELATION FILTER METHODS
Authors: Remelko Ullima Fathonah
Published: May 2023

Pedestrian safety on pedestrian lanes on the side of highways or roads in housing with heavy or quiet traffic conditions needs to be a public concern. Security that must be considered, object tracking is needed to carry out surveillance in improving pedestrian security, and it is also necessary to install thermal camera devices to find out the position of objects such as humans, in various positions of viewpoints that can be applied and applied to monitor the environment. To classify objects such as humans who are in dark or low-light conditions, namely by using the Kernelized Correlation Filter (KCF) tracking method, Support Vector Machines (SVM), and L1 Tracker Using Accelerated Proximal Gradient Approach (L1APG) based on a distance of 10 meters, 15 meters, 20 meters and the size of the object in the dataset. The results of the study with 1684 image inputs. Good performance for each success plot distance on the SVM method is 99.25%, 99.75%, 98.74% because it can track successfully based on the object being traced. Good performance for each precision plot distance on the KCF method of 51.88%, 46.8%, 63.81% has precise accuracy results against the object being tracked.
Content Management System Development for Medical Web Applications
Authors: Adrian Monterico , Ahmad Munawar
Published: May 2023

The world of the web and the internet today has become one of the centers for exchanging information between humans, one of which is shown by the development of web applications in the form of content management systems (CMS). By being based on JavaServer Pages (JSP), which has the advantages of being platform-independent, inexpensive and free, and easy to develop, it is possible to become an alternative solution to meet today's general medical needs, namely online and web-based, extensible and customizable. , robust and efficient, secure and authenticated, and easy to develop and maintain. there is a need that turns out to be equally owned and used by only a few medical institutions or there is even a need that is shared by all of them. These needs are developed and used as a standard so that web applications in the medical field are universal and can be used by any medical institution, anywhere, and anywhere. As a result, medical needs that can be implemented into a web application and can be universally applicable.
TBC Bacteria Detection in Microscopic Image With Watershed Countur Method
Authors: Dawwas Rodan Hilmi
Published: May 2023

Tuberculosis (TB) is an infectious disease that can be detected using a sputum sample. TB cases in Indonesia have spread throughout the region; the highest cases are in West Java. This problem makes the government do some handling and prevention of TB disease. The Bandung City Health Office (DKKB) conducted a cross-test to diagnose TB using a sputum sample. So in this study, a TB bacteria detection system, namely Mycobacterium Tuberculosis (MTB), will be made in sputum samples and their number to diagnose TB. Detection and calculation of the number of MTB are done by processing the image on the sputum sample using the watershed contour detection method. In this study, sputum sample data were obtained from DKKB. The acquisition of microscopic images at each point of the field of view is carried out using an SLR camera connected directly to the microscope to replace the function of the ocular lens. In this study, the microscopic sputum sample images were classified into positive and negative using the watershed and colorspace methods and were tested on a total of 90 microscopic images. From the system testing results, the system accuracy level is 100%, and the system precision is 100% for the detection of TB diagnosis. The system processing time averaged 5.811 seconds for 90 images used.
The NDNS PERFORMANCE WITH VARIATION OF TOPOLOGY AND PREFIX ON NAMED DATA NETWORKING
Authors: Daffa Muhammad , Yovita Leanna Vidya , Wibowo Tody Ariefianto
Published: May 2023

NDNS is DNS embedded in Named Data Network (NDN) architecture as a distributed database system to support NDN caching and know the content's location. In this research, the simulation performed using two topologies, Abilene and PAN-Europe with changes to their prefixes. This simulation conducted to see performance of NDNS with minimal ability to cache on NDN router or Caching Resolver. From simulation results, the variation of prefix at Second Level Domain and Top Level Domain there is no difference in average delay in both topologies, namely 1% increase in average delay as the variation of prefix increases. There is a decrease in the Cache Hit Ratio by 0.16% (Abilene) and 0.18% (PAN-Europe) because the probability of getting cached data decreases as the prefix varies. In the change in interest frequency, there is an increase of 0.4% in average delay and the Cache Hit Ratio decreases by 0.08% in both topologies as the frequency of interest per second increases. NDNS with cache in Router and Caching Resolver get 43% lower average delay (Abilene) and 44% (PAN-Europe) than NDN with cache in Router and 57% lower (Abilene) and 60% (PAN-Europe) than NDNS with cache in Caching Resolver only.
O uso da espécie Aloe vera L. na estética
Authors: Marques Dhéssica Pamela , Alberini Rita de Cássia , Berté Rodrigo , Santos Vera Lucia Pereira dos
Published: May 2023

Objetivo: Evidenciar a importância da espécie Aloe vera L. e o seu uso na área da estética. Revisão bibliográfica: Os resultados mostram que de suas folhas obtém-se uma seiva incolor e viscosa, formada por água e compostos ativos como polissacarídeos, flavonoides, saponinas, esteroides, aminoácidos, sais minerais e vitaminas. O seu uso para a indústria da beleza é vantajoso devido sua ação hidratante e cicatrizante, por estimular fibroblastos, além de fornecer mais oxigênio para os tecidos resultando no aumento da vascularização e na quantidade de produção de colágeno no processo de cicatrização. Considerações finais: A facilidade de cultivo e a popularidade de Aloe vera a torna uma espécie utilizada na indústria cosmética e farmacêutica e que desperta o interesse para o desenvolvimento de cosméticos com diversas finalidades, por apresentar princípios ativos encontrados na seiva incolor presente no interior de suas folhas, sendo utilizados como hidratante e auxiliar no processo de cicatrização.
Follicular mycosis fungoides: Clinicohistopathologic features and outcomes in a series of 12 Chinese cases
Authors: Feng Xiwei , Xie Yao , Li Fan , Wang Lin
Published: May 2023

Background

Follicular mycosis fungoides is a distinct variant of mycosis fungoides with a broad clinical spectrum. Recently, many studies have indicated that follicular mycosis fungoides should be divided into different subtypes with disparate prognoses.

Objective

To define the clinicohistopathologic features and outcomes of follicular mycosis fungoides and to identify risk factors that may be related to the prognosis of Chinese patients with follicular mycosis fungoides.

Materials and methods

We conducted a single-centre retrospective study and reviewed the clinical, histopathologic and immunophenotypic data of 12 patients diagnosed with follicular mycosis fungoides between 2009 and 2020 in the Department of Dermatology of West China Hospital of Sichuan university.

Results

A total of 12 patients (seven males and five females) with a mean age of 30 ± 14 years (age range 16–55 years) were included. Scalp and face were the most common involved sites (100%). Follicular papules, acneiform lesions, plaques, and nodules, were the main clinical presentations. Histopathological findings were consistent with the classic manifestations of follicular mycosis fungoides, including folliculotropism, perifollicular and intrafollicular lymphocytic infiltrates and mucinous degeneration. Interferon α-1b was the most common treatment. Four patients died of follicular mycosis fungoides in three years. Notably, immunohistochemical analysis revealed a decreased number of CD20+ cells in the deceased patients.

Limitations

This is a retrospective evaluation with a small number of cases; further prospective studies are warranted to support our inferences.

Conclusion

Our patients were much younger than in previous studies. The observed difference in this cohort may be explained by race, in addition to the limited number of cases. A decreased number of B cells might be associated with a poor prognosis, and more studies are necessary to discover the role of B cells in follicular mycosis fungoides as well as in mycosis fungoides.
Dermatology journals from India: A critical appraisal of the journal metrics
Authors: Mehta Hitaishi , Bishnoi Anuradha , Vinay Keshavamurthy , Dogra Sunil
Published: May 2023

Background

Bibliometrics refer to documents and citation-based measures that measure different aspects of performance of a journal, including impact, output and prestige.

Objective

The aim of this study was to collect bibliometric data of various Indian dermatology journals as well as Indian journals from other disciplines, in order to compare relative performances.

Methods

Journal metrics pertaining to various Indian journals, both from dermatology [Indian Journal of Dermatology, Venereology and Leprology (IJDVL), Indian Journal of Dermatology (IJD), Indian Dermatology Online Journal, Indian Journal of Pediatric Dermatology and International Journal of Trichology] and other disciplines [Indian Journal of Medical Research (IJMR), Indian Journal of Pediatrics (IJP), Indian Journal of Ophthalmology and Indian Journal of Pharmacology] were sought. Data pertaining to the following 8 metrics during the year 2021 was collected: Journal Impact factor, SCImago Journal Rank, h5-index, Eigenfactor score and normalized Eigenfactor Score, Journal Citation Indicator, Scimago Journal and Country Rank H-index, CiteScore and Source Normalized Impact per Paper.

Results

Among Indian dermatology journals, for the year 2021, IJDVL had the highest impact factor (2.217) and h-index (48). IJD led in terms of prestige metrics such as SCImago Journal Rank (0.403), Eigenfactor score (0.00231) and Source Normalized Impact per Paper (1.132). IJDVL underperformed with respect to an average dermatology journal on all three prestige metrics. Among selected journals from other disciplines, two (IJMR and IJP) had impact factor exceeding five, despite lagging behind IJDVL two years ago. Most had normalized scores exceeding 1, indicating better performance than an average journal from their respective fields.

Limitations

Non-inclusion of altmetrics related data

Conclusion

IJDVL is one of the leading Indian journals in the field of dermatology, followed closely by IJD. A rise in IJDVL influence is evident over the past decade, as evident by various metrics. However, the progress still trails behind the average of global dermatology journals as evident by the field-normalized journal metrics, indicating potential for further growth of journal influence.
Retrospective analysis of ultrathin skin grafting over carbon dioxide ablated lesions supplemented with excimer lamp (308 nm) therapy in stable vitiligo
Authors: Savant Jr Sushil S. , Savant Satish S.
Published: May 2023

Background

Of all the tissue or cellular grafting techniques used in the treatment of vitiligo, melanocyte transplant/transfer through ultrathin skin grafting (UTSG) provides rapid onset of regimentation. The regimentation process is further accelerated with a combination of psoralen and ultraviolet A radiation, or psoralen and ultraviolet A obtained by sunlight or narrowband ultraviolet light B, or excimer laser/lamp (308 nm).

Aims

We assessed the efficacy of carbon dioxide laser ablation followed by melanocyte transplant/transfer through ultrathin skin graft sheet/sheets and further treated by excimer lamp therapy in patients with stable vitiligo.

Methods

One hundred ninety-two patients with stable vitiligo were treated with UTSG following carbon dioxide laser ablation and patients were then put on excimer lamp therapy. Primary efficacy was determined in terms of grades of regimentation and colour match at the end of 1-year.

Results

A total of 192 stable vitiligo patients with a mean age of 32.71 ± 8.55 years were recruited. Of the total 410 lesions, 394 showed excellent regimentation indicating a success rate of 96.1% at 1-year follow-up, whereas 16 (3.9%) lesions present on fingertips and toe tips showed poor or no regimentation at 3-month and 1-year follow-up. With regards to colour match, 394 (96.1%) lesions had achieved excellent colour match, and 16 lesions (3.9%) had poor or no colour match at 1-year follow-up.

Limitations

This was a single-center study with a small sample size.

Conclusion

The effectiveness of carbon dioxide laser ablation followed by melanocyte transfer/transplant through ultra-thin skin graft sheet/sheets when combined with excimer lamp therapy provides favourable cosmetic outcomes with rapid onset of regimentation in stable vitiligo.
Outcome of COVID-19 in patients with autoimmune bullous diseases
Authors: De Dipankar , Ashraf Raihan , Mehta Hitaishi , Handa Sanjeev , Mahajan Rahul
Published: May 2023

Background

Data on outcomes of Coronavirus disease 2019 (COVID-19) infection in autoimmune bullous diseases (AIBDs) patients is scarce.

Materials and methods

This single-centre survey-based-observational study included patients registered in the AIBD clinic of the Postgraduate Institute of Medical Education and Research, Chandigarh, India. All registered patients were contacted over telephone between June and October 2021. A survey was conducted after obtaining informed consent.

Results

Among 1389 registered patients, 409 completed the survey. Two hundred and twenty-two (55.3%) patients were females and 187 (45.7%) were males. The mean age was 48.52 ± 14.98 years. Active disease was reported by 34% patients. The frequency of COVID-19 infection in responders was 12.2% (50/409), with a case-fatality ratio of 18% (9/50). Rituximab infusion after the onset of pandemic significantly increased the risk of COVID-19 infection. Active AIBD and concomitant comorbidities were significantly associated with COVID-19 related death.

Limitation

Relative risk of COVID-19 infection and complications among AIBD patients could not be estimated due to lack of control group. The incidence of COVID-19 in AIBD could not be determined due to lack of denominator (source population) data. Other limitations include telephonic nature of the survey and lack of COVID-19 strain identification.

Conclusion

Use of rituximab is associated with higher probability of COVID-19 infection, while advanced age, active disease and presence of comorbidities may increase the risk of COVID-19 mortality in AIBD patients.
Cicatrization of Oncological Wounds by Autologous Fibrin Biopolymer Dressing Treatment: A Case Series
Authors: de Carvalho Chayane , Fernandes Beatriz , Dalmedico Michel , de Souza Mauren
Published: May 2023

Introduction. Traditional therapies used to treat chronic wounds are often expensive and, in general, are not adequate to support healing. A promising alternative to conventional dressings is the autologous biopolymer FM, full of cytokines and growth factors that accelerate the healing process of wounds of various etiologies. Materials and Methods. The authors report 3 cases in which FM was used to treat chronic oncological wounds that had been conventionally treated for more than 6 months with no sign of healing. Results. Among the 3 reported cases, there was complete healing of 2 wounds. The other lesion did not heal, mainly due to the location (at the base of the skull). However, it significantly reduced its area, extension, and depth. No adverse effects or hypertrophic scar formation were recorded, and the patients reported an absence of pain from the second week of FM application. Conclusions. The proposed FM dressing approach was effective in healing and speeding up tissue regeneration. It can also be considered one of the most versatile delivery systems to the wound bed, as it is an excellent carrier of growth factors and leukocytes.
Revitalisasi Pemikiran Ibnu Khaldun Tentang Ekonomi (1332 – 1406)
Authors: Andrian Saputra  , Husni Thamrin
Published: May 2023

Tujuan penelitian ini untuk memberikan gambaran bahwa dalam aktivitas publik tertentu, proses pemikiran tertentu juga akan muncul (untuk situasi ini tentang ekonomi). Terlebih lagi, Ibnu Khaldun adalah seorang ulama yang mampu dalam berbagai bidang studi, baik politik, sosial, filosofis, diverifikasi, dan masalah keuangan itu sendiri. Metodologi yang digunakan dalam penelitian ini adalah strategi penilaian subjektif yang menjelaskan investigasi kontekstual dalam pandangan survei menulis. Pemeriksaan logika adalah tes yang ditingkatkan, menggunakan berbagai sumber bukti subjektif. Dari informasi yang di dapat kemudian diakumulasikan berdasarkan prinsip-prinsip dan pengujian sesuai standar penyusunan agar dapat bekerja dengan pembicaraan isu-isu yang ada. Keberadaan ekskursi dan kondisi tujuan yang dialami oleh Ibnu Khaldun telah menjadikannya seorang sarjana yang lengkap, ahli dalam ilmu sosial dan sejarah, namun matang dalam hal keuangan. Para perintis harus ditemukan kembali oleh para ahli keuangan barat setelah sekitar 4-5 abad setelah kematiannya. Berbagai pertimbangan yang dikemukakan dalam tulisan ini tidak mencakup semua gagasan keuangan yang diperoleh Ibnu Khaldun dalam karyanya yang luar biasa Muqaddimah, oleh karena itu penting untuk terus mendapatkan gagasan keuangan Ibnu Khaldun secara luas.
Designing solvent systems in chemical processes using self-evolving solubility databases and graph neural networks
Authors: Kim Yeonjoon , Jung Hojin , Kumar Sabari , Claiborne Alex , Paton Robert S. , Kim Seonah
Published: May 2023

Designing solvent systems is the key to achieving the facile synthesis and separation of desired products from chemical processes. In this regard, many machine-learning models have been developed to predict the solubilities of given solute-solvent pairs. However, breakthroughs in developing predictive models for solubility are needed, which can be accomplished through a remarkable expansion and integration of experimental and computational solubility databases. To maximize predictive accuracy, these two databases should not be separately trained when developing ML models. In addition, they should not be simply combined without reconciling the discrepancies between different magnitudes of errors and uncertainties. Here, we introduce self-evolving solubility databases and graph neural networks developed through semi-supervised self-training approaches. Solubilities from quantum-mechanical calculations are referred to during semi-supervised learning, but they are not directly added to the database. Such methodologies enable the augmentation of databases while correcting the discrepancy between experiments and computation and improving the predictive accuracy against experimental solubilities. The resulting model was successfully applied to two practical examples relevant to solvent selection in organic reactions and separation processes: (i) linear relationship between reaction rates and solvation free energy for three organic reactions, and (ii) partition coefficients for lignin-derived monomers and drug-like molecules.
Ligand Accelerated Hydrogen Isotope Exchange: Switching C-H Activation from Functionalization Towards C-D Bond Formation
Authors: Jiang Zhi-Jiang , Xu Dawei , Lu Jiakai , Bai Jianfei , Tang Bencan , Chen Jia , Gao Zhanghua
Published: May 2023

Hydrogen isotope exchange (HIE) has emerged as a unique strategy for labelling, affording plenty of deuterated chemicals with varieties in patterns. Although the HIE based on electrophilic C-H activation could utilize the economic heavy water as deuterium source, the poor kinetic feature, as well as the side reactions still hampered its further application. In this work, an acceleration strategy for HIE development had been proposed based on ligand-modified C-H activation intermediate. According to the strategy, high efficiency HIE condition could be stemmed from the moderate-potency conditions in the corresponding functionalizations, which may fail in balancing the C-H activation and the subsequent coupling. Thus, as a proof of concept, experimental evidence was provided by different ligand preferences of HIE and functionalizations based on a non-directed Pd-catalyzed dual-ligand system. The competing experiment suggested the functionalization could be partially suppressed by using steric MPAA ligands, which facilitated the progression of C-D bond formation.
Interfacing Whole Cell Biocatalysis with a Biocompatible Pictet-Spengler Reaction for One-Pot Syntheses of Tetrahydroisoquinolines and Tryptolines
Authors: Andersen Campbell , Domaille Dylan W.
Published: May 2023

Biocatalytic processes are highly selective and specific. However, their utility is limited by the comparatively narrow scope of enzyme-catalysed transformations. To expand product scope, we are developing biocompatible processes that combine biocatalytic reactions with chemo-catalysis in single-flask processes. Here, we show that a chemocatalysed Pictet-Spengler annulation can be interfaced with biocatalysed alcohol oxidation. This two-step, one-pot cascade reaction converts tyramine and aliphatic alcohols to tetrahydroquinoline alkaloids in aqueous buffer at mild pH. Tryptamine derivatives are also efficiently converted to tryptolines. Optimization of stoichiometry, pH, reaction time, and whole-cell catalyst deliver the tetrahydroisoquinolines and tryptolines in >90% and >40% isolated yield, respectively, with excellent regioselectivity.
Arenes and Heteroarenes C–H Functionalization Under Enabling Conditions: Electrochemistry, Photoelectrochemistry & Flow Technology
Authors: Murtaza Ayesha , ulhaq Zia , Shirinfar Bahareh , Rani Sadia , Aslam Samina , Martins Guilherme M. , Ahmed Nisar
Published: May 2023

C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species. In many cases, they often require pre-functionalization of starting molecules. Such pre-activating measures cause waste generation and their separation from the final product is also troublesome. In such a scenario, reactions activating elements generating from renewable energy resources such as electricity and light would be more efficient, green, and cost-effective. Further, incorporation of growing flow technology in chemical transformation processes will accelerate the safer accesses of valuable products. Arenes & (hetero) arenes are ubiquitous in pharmaceuticals, natural products, medicinal compounds, and other biologically important molecules. Herein, we discussed enabling tools and technologies used for the recent C–H bonds functionalization of Arenes / (Hetero)Arenes.
Hydrogen sulfide-releasing nanocascade templated by glucose oxidase for diabetic infection treatment
Authors: Ge Yuxuan , Rong Fan , Lu Yujia , Wang Zixin , Liu Jinyu , Chen Junsheng , Li Wei , Wang Yin
Published: May 2023

Diabetic ulcer receives much attention in recent years due to its high incidence and mortality, promoting the scientific community to develop various strategies for such chronic disease treatments. However, the therapeutic outcome of these approaches is highly compromised by the invasive bacteria and severe inflammatory ulcer microenvironment. To overcome these dilemmas, microenvironment-responsive self-delivery GOx@MnS nanoparticles (NPs) are developed by a one-step biomineralization. When encountered with high glucose level in the ulcer site, GOx catalyze glucose to decrease the local pH and trigger the steady release of both manganese ions (Mn2+) and hydrogen sulfide (H2S). Mn2+ react with hydrogen peroxide to generate hydroxyl radical for the elimination of bacterial infection, meanwhile H2S is able to suppress the inflammatory response and accelerate diabetic wound healing through macrophage polarization. The excellent biocompatibility, strong bactericidal activity, and considerable immunomodulatory effect promise GOx@MnS NPs great therapeutic potential for diabetic wound treatment.
The Role of Reading the Al-Quran on Peace of Mind
Authors: Ahmad Khadher bin , Huda Dede Musa Samsul
Published: May 2023

Al-Qur’an is the guideline for human life, the holy book that there is no doubt in it, and even the medicine for all heart ailments. But sometimes, reading al-Qur’an becomes boring and does not necessarily have promising implications. This study aims to determine the role of reading al-Qur’an on the peace of mind of male students at the modern Islamic boarding school Al-Ihsan Baleendah, Bandung. The method used in this study is a qualitative descriptive method with a case study approach. Data collection techniques using observation and interviews. The subjects of this study were five people from a population of 12 who attended the congregation of reciting Qur’an (Jamiatul Qura—JMQ) at the Al-Ihsan Baleendah Modern Islamic Boarding School, Bandung. The sampling technique used is students. After the data is collected, the researchers use a qualitative descriptive analysis technique. The results showed that the mental condition of the male students who participated in the JMQ was calm and serene. The method of reading al-Qur’an is to follow adab ahlaqiyah and inner heart. Reading al-Qur’an and following the Shari'a recommended by religion. Reading al-Qur’an significantly increases the peace of mind of male students who attend JMQ at the Al-Ihsan Baleendah Modern Islamic Boarding School, Bandung.
Active learning improves academic achievement and learning retention in K-12 settings: A meta-analysis
Authors: Özgür Tutal
Published: May 2023

The meta-analysis investigates the impact of active learning on K–12 students' academic achievement and learning retention. A thorough search of published and unpublished research reveals 398 studies for academic achievement and 88 studies for learning retention. The analysis demonstrates that active learning has a significant positive impact on academic achievement (g = 1.005) and learning retention (g = 1.204) in comparison to teacher-led instruction under the random-effects model. The analysis conducted to identify publication bias suggest that the findings are not influenced by publication bias. However, there is significant variation in effect sizes across studies. Therefore, moderator analysis is conducted for eight possible moderator variables. The analysis indicate that the impact of active learning on academic achievement is moderated by domain subject, educational level, course implementer, region, and group size. Conversely, the impact of active learning on learning retention is moderated by publication type, domain subject, educational level, experimental duration, and region.
The Influence of Audi Fees in the Nexus Between Corporate Sustainability Engagement and Earnings Management
Authors: Rahman Mashiur , Rasid Siti Zaleha Binti Abdul , Hussain Sarfraz
Published: May 2023

Purpose: This study aims to examine the relationship between corporate sustainability engagement and earnings management and the function of audit fees in that relationship.
 
Theoretical framework: Sustainability reporting and earnings management may not be applicable or generate the same outcomes due to differences in societal values, culture, and development levels between developed and developing countries, which emphasises the need for this study to focus on Bangladesh, an emerging market.
 
Design/methodology/approach: This research employs content analysis to determine the magnitude of the sustainability activities for 2010 to 2020 of the banking sectors of Bangladesh. Additionally, this study uses discretionary accruals as a proxy for earnings management.
 
Findings: According to the results, there is a significant positive relationship between corporate sustainability engagement and earnings management, with audit fees serving as a moderator in the negative direction. According to these findings, high audit costs are likely to compel bank executives to submit high-quality financial reports and restrict their use of sustainability activities to management opportunism.
 
Research, practical and social implication: The study's findings should concern researchers and corporate authorities interested about managers' earnings management aspirations. The findings will immediately impact academics and decision-makers in countries with similar financial and governmental systems.
 
Originality/value: According to sustainability reporting studies, disclosures have been driven by the need to calm concerns about a company's authenticity. This paper acknowledges the need for increased audit fees for quality auditors, but it argues that rigorous audit procedures are more important for raising financial disclosure standards.
Does the Board Influence the Bank’s Performance? An Islamic & Commercial Banking Experience
Authors: Bansal Atul , Samontaray Durga Prasad , Aljalahma Abdulla Khalid Ahmed , Khadim Ms Dania Tanweer
Published: May 2023

Purpose: This study investigates to explore the impact of corporate governance and the performance of the banking Industry of Bahrain for the period of 2012–2020.
 
Theoretical framework: This research is to take a look at corporate governance actions and how it affects the actual bank performance, there are four chosen banks for this particular purpose that are listed under the Stock exchange of Bahrain (SEB) and the Central bank of Bahrain (CBB).
 
Design/methodology/approach: The methodology for the study is based on pooled data collection from Islamic and commercial banks of Bahrain. All the data will be extracted from the chosen banks’ audited annual financial statements for 9 years ranging from 2012 to 2020. To go ahead with this research two kinds of dependent variables also called performance measures are (ROA, and ROE), and six kinds of independent variables were selected (CEO duality, the board size, board independence, female directorship, number of BOD meetings, and lastly board members expertise) for us to understand the bank performance better.
 
Findings: The results showed good connections between the (BS) and bank performance as well as the (NBDM), while the (BDI) and (FD) displayed a negative link, and (BDME) and (CEOD) showed no signs of a relationship because all banks had separate people holding those positions instead of one. And even though (BDME) is proven and is logically impactful some analyses failed to show the true linkage.
 
Research, Practical & Social implications: These results of the study will help the banking industry, regulators, investors, and government to understand the board’s influence on the firm performance. 
 
Originality/value: Original Research Article.
Development of the Economic Growth Model Reducing Poverty in Central Java Indonesia
Authors: Arwani Agus , Safi’I Muhammad Aris , Zawawi  , Tamara Karima , Masrur Muhamad
Published: May 2023

Purpose:  Research purposes of analyzing the Human Development Index open unemployment rate to Poverty with intervening variables of economic development in Central Java Province in 2015-2020.
 
Theoretical framework:  Human Development measures human development achievements based on a number of basic components of quality of life. Unemployment is a macroeconomic problem that directly affects human survival. Poverty is the inability to meet the minimum standard of living, where the measurement of poverty is based on consumption. The major theory used relates to the Neo-liberal and Social Democracy paradigms. Economic growth has a correlation with the number of poor people, where high economic growth will have an impact on reducing the number of poor people, with the assumption that economic growth is pro-poor. 
 
Design/methodology/approach:  This research uses a quantitative approach. The analysis uses the website's secondary data published by the Central Statistics Agency. The number of data is 210, processed using AMOS to determine the direct and indirect effects and a Sobel calculator to assess the impact of the intervening variables.
 
Findings:  The results showed that the Human Development Index did not significantly impact Economic Growth, the Open Unemployment Rate substantially influenced Economic Growth, and the Human Development Index significantly affected Poverty. Open Unemployment Rate has no significant impact on Poverty. Economic growth has no significant effect on Poverty. The Growth of Economic can not mediate impact human development index on Poverty. Economic growth can not mediate result of the open unemployment rate to Poverty 
 
Research, Practical & Social implications: the research can be carried out in different places with a broader objective. Provincial or district/city governments in Central Java Province as policy material and or policy projections in the future
 
Originality/value: The findings of this study can be generalized to different provinces so that they can be used as material for government policies to increase the human development index, reduce unemployment, increase economic growth so that poverty will decrease.