bluuebunny/crossref_metadata_2025 huggingface dataset:
Calibration Factor for ASCE 41-17 Modeling Parameters for Stocky Rectangular RC Columns
Authors: Han Sang Whan , Lee Chang Seok , Paz Zambrana Mary Ann , Lee Kihak
Published: November 2019

Existing old reinforced concrete (RC) buildings could be vulnerable to large earthquake events. Most columns in such buildings have insufficient reinforcement details, which may experience failure during an early loading stage. The failure of columns may lead to partial or complete collapse of entire building systems. To prepare for an adequate retrofit plan for columns, it is necessary to simulate the cyclic behavior of columns using a numerical model with adequate values of constituent modeling parameters. The nonlinear component modeling parameters are specified in ASCE 41-17. However, the experiments on stocky RC columns suggest that ASCE 41-17 nonlinear component modeling parameters do not reflect the RC column behavior adequately. To accurately simulate the nonlinear load–deformation responses of stocky RC columns with low span-to-depth ratio, this study proposes a calibration factor for ASCE 41-17 RC column modeling parameters. For this purpose, this study collected test data of 47 stocky column specimens. Based on the test data, empirical equations including the calibration factor for modeling parameters “a” and “b” in ASCE 41-17 were proposed. The accuracy of the proposed equation was verified by comparing the measured and calculated envelope curves.
Evaluation of Skin Friction Drag Reduction in the Turbulent Boundary Layer Using Riblets
Authors: Takahashi Hidemi , Iijima Hidetoshi , Kurita Mitsuru , Koga Seigo
Published: November 2019

A unique approach to evaluate the reduction of skin friction drag by riblets was applied to boundary layer profiles measured in wind tunnel experiments. The proposed approach emphasized the turbulent scales based on hot-wire anemometry data obtained at a sampling frequency of 20 kHz in the turbulent boundary layer to evaluate the skin friction drag reduction. Three-dimensional riblet surfaces were fabricated using aviation paint and were applied to a flat-plate model surface. The turbulent statistics, such as the turbulent scales and intensities, in the boundary layer were identified based on the freestream velocity data obtained from the hot-wire anemometry. Those turbulent statistics obtained for the riblet surface were compared to those obtained for a smooth flat plate without riblets. Results indicated that the riblet surface increased the integral scales and decreased the turbulence intensity, which indicated that the turbulent structure became favorable for reducing skin friction drag. The proposed method showed that the current three-dimensional riblet surface reduced skin friction drag by about 2.8% at a chord length of 67% downstream of the model’s leading edge and at a freestream velocity of 41.7 m/s (Mach 0.12). This result is consistent with that obtained by the momentum integration method based on the pitot-rake measurement, which provided a reference dataset of the boundary layer profile.
Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications
Authors: Perea García José , Arribas Julia , Cañete Ángel , García Juan Luis , Álvaro Edurne , Tapial Sandra , Narváez Cristina , Vivas Alfredo , Brandáriz Lorena , Hernández-Villafranca Sergio , Rueda Daniel , Rodríguez Yolanda , Pérez-García Jessica , Olmedillas-López Susana , García-Olmo Damián , Cavestro Giulia Martina , Urioste Miguel , Goel Ajay , González-Sarmiento Rogelio
Published: November 2019

Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRC.
Enhanced Lycopene Production in Escherichia coli by Expression of Two MEP Pathway Enzymes from Vibrio sp. Dhg
Authors: Kim Min Jae , Noh Myung Hyun , Woo Sunghwa , Lim Hyun Gyu , Jung Gyoo Yeol
Published: November 2019

Microbial production is a promising method that can overcome major limitations in conventional methods of lycopene production, such as low yields and variations in product quality. Significant efforts have been made to improve lycopene production by engineering either the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway or mevalonate (MVA) pathway in microorganisms. To further improve lycopene production, it is critical to utilize metabolic enzymes with high specific activities. Two enzymes, 1-deoxy-d-xylulose-5-phosphate synthase (Dxs) and farnesyl diphosphate synthase (IspA), are required in lycopene production using MEP pathway. Here, we evaluated the activities of Dxs and IspA of Vibrio sp. dhg, a newly isolated and fast-growing microorganism. Considering that the MEP pathway is closely related to the cell membrane and electron transport chain, the activities of the two enzymes of Vibrio sp. dhg were expected to be higher than the enzymes of Escherichia coli. We found that Dxs and IspA in Vibrio sp. dhg exhibited 1.08-fold and 1.38-fold higher catalytic efficiencies, respectively. Consequently, the heterologous overexpression improved the specific lycopene production by 1.88-fold. Our findings could be widely utilized to enhance production of lycopene and other carotenoids.
Enhancing the Water Resistance of Mn-MOF-74 by Modification in Low Temperature NH3-SCR
Authors: Wang Sheng , Gao Qiang , Dong Xiuqin , Wang Qianyun , Niu Ying , Chen Yifei , Jiang Haoxi
Published: November 2019

In this study, Mn-MOF-74 was successfully synthesized and further modified via two paths for enhanced water resistance. The structure and morphology of the modified samples were investigated by a series of characterization methods. The results of selective catalytic reduction (SCR) performance tests showed that polyethylene oxide-polypropylene-polyethylene oxide (P123)-modified Mn-MOF-74 exhibited outstanding NO conversion of up to 92.1% in the presence of 5 vol.% water at 250 °C, compared to 52% for Mn-MOF-74 under the same conditions. It was concluded that the water resistance of Mn-MOF-74 was significantly promoted after the introduction of P123 and that the unmodified P123-Mn-MOF-74 was proven to be a potential low-temperature SCR catalyst.
Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease
Authors: Bussiere Renaud , Oulès Bénédicte , Mary Arnaud , Vaillant-Beuchot Loan , Martin Cécile , El Manaa Wejdane , Vallée Déborah , Duplan Eric , Paterlini-Bréchot Patrizia , Alves Da Costa Cristine , Checler Frédéric , Chami Mounia
Published: November 2019

Dysregulation of the Endoplasmic Reticulum (ER) Ca2+ homeostasis and subsequent ER stress activation occur in Alzheimer Disease (AD). We studied the contribution of the human truncated isoform of the sarco-endoplasmic reticulum Ca2+ ATPase 1 (S1T) to AD. We examined S1T expression in human AD-affected brains and its functional consequences in cellular and transgenic mice AD models. S1T expression is increased in sporadic AD brains and correlates with amyloid β (Aβ) and ER stress chaperone protein levels. Increased S1T expression was also observed in human neuroblastoma cells expressing Swedish-mutated β-amyloid precursor protein (βAPP) or treated with Aβ oligomers. Lentiviral overexpression of S1T enhances in return the production of APP C-terminal fragments and Aβ through specific increases of β-secretase expression and activity, and triggers neuroinflammation. We describe a molecular interplay between S1T-dependent ER Ca2+ leak, ER stress and βAPP-derived fragments that could contribute to AD setting and/or progression.
Comparative Study of Ni-Sn Alloys Electrodeposited from Choline Chloride-Based Ionic Liquids in Direct and Pulsed Current
Authors: Rosoiu Sabrina Patricia , Pantazi Aida Ghiulnare , Petica Aurora , Cojocaru Anca , Costovici Stefania , Zanella Caterina , Visan Teodor , Anicai Liana , Enachescu Marius
Published: November 2019

This work presents, for the first time, the electrodeposition of Ni-Sn alloys in pulse current, from deep eutectic solvents (choline chloride: ethylene glycol eutectic mixture). Additionally, in this study, we report a comparison of the electrodeposition methods known as pulse and direct current. The elemental composition of the films, evaluated from EDX, remained almost constant independently on the electrodeposition parameters. The XRD data revealed the presence of the NiSn metastable phase, which has been confirmed by DSC analysis. This phase shows a nanocrystalline structure with crystallite sizes between 12 and 20 nm. The use of pulse current electrodeposition method has led to an improvement of alloys’ mechanical properties. Moreover, by controlling the electrodeposition parameters, we succeeded in tuning the mechanical properties of the coatings prepared through the PC method. We showed that the hardness parameters exhibited by the Ni-Sn alloys are strongly dependent on their crystallite sizes.
Application of Fundamental Models for Creep Rupture Prediction of Sanicro 25 (23Cr25NiWCoCu)
Authors: He Junjing , Sandström Rolf
Published: November 2019

Creep rupture prediction is always a critical matter for materials serving at high temperatures and stresses for a long time. Empirical models are frequently used to describe creep rupture, but the parameters of the empirical models do not have any physical meanings, and the model cannot reveal the controlling mechanisms during creep rupture. Fundamental models have been proposed where no fitting parameters are involved. Both for ductile and brittle creep rupture, fundamental creep models have been used for the austenitic stainless steel Sanicro 25 (23Cr25NiWCoCu). For ductile creep rupture, the dislocation contribution, solid solution hardening, precipitation hardening, and splitting of dislocations were considered. For brittle creep rupture, creep cavitation models were used taking grain boundary sliding, formation, and growth of creep cavities into account. All parameters in the models have been well defined and no fitting is involved. MatCalc was used for the calculation of the evolution of precipitates. Some physical parameters were obtained with first-principles methods. By combining the ductile and brittle creep rupture models, the final creep rupture prediction was made for Sanicro 25. The modeling results can predict the experiments at long-term creep exposure times in a reasonable way.
An Integrative Dynamic Model of Colombian Population Distribution, Based on the Maximum Entropy Principle and Matter, Energy, and Information Flow
Authors: Cardona-Almeida César , Obregón Nelson , Canales Fausto A.
Published: November 2019

Human society has increased its capacity to exploit natural resources thanks to new technologies, which are one of the results of information exchange in the knowledge society. Many approaches to understanding the interactions between human society and natural systems have been developed in the last decades, and some have included considerations about information. However, none of them has considered information as an active variable or flowing entity in the human–natural/social-ecological system, or, moreover, even as a driving force of their interactions. This paper explores these interactions in socio-ecological systems by briefly introducing a conceptual frame focused on the exchange of information, matter, and energy. The human population is presented as a convergence variable of these three physical entities, and a population distribution model for Colombia is developed based on the maximum entropy principle to integrate the balances of related variables as macro-state restrictions. The selected variables were electrical consumption, water demand, and higher education rates (energy, matter, and information). The final model includes statistical moments for previous population distributions. It is shown how population distribution can be predicted yearly by combining these variables, allowing future dynamics exploration. The implications of this model can contribute to bridging information sciences and sustainability studies.
Case Study of Thermal Diagnostics of Single-Family House in Temperate Climate
Authors: Specjał Aleksandra , Lipczyńska Aleksandra , Hurnik Maria , Król Małgorzata , Palmowska Agnieszka , Popiołek Zbigniew
Published: November 2019

Reduction of the primary energy consumption is a crucial challenge for the building sector due to economic and environmental issues. Substantial savings could be achieved within the household. In this paper, we investigate the energy performance of a single-family house located in the temperate climate. The assessment is based on the comprehensive thermal diagnostic of the building performed on-site and via computational analyses. The on-site measurements included diagnostics of the building envelope, heat source, heating and domestic hot water system, ventilation system, and indoor environmental quality. Analyses confirmed that the studied building, which was built in 2008, meets the legislation requirements for the primary energy usage at that time and nowadays. However, results show discrepancies between energy performance obtained through on-site measurements and computational methods following regulations. Partially, discrepancies are a result of differences on normative values and how the building is operated in practice. It is also showed how important the role in the assessment of energy consumption through measurements is played by the measurement period.
A Comprehensive Survey on Phasor Measurement Unit Applications in Distribution Systems
Authors: Hojabri Mojgan , Dersch Ulrich , Papaemmanouil Antonios , Bosshart Peter
Published: November 2019

Synchrophasor technology opens a new window for power system observability. Phasor measurement units (PMUs) are able to provide synchronized and accurate data such as frequency, voltage and current phasors, vibration, and temperature for power systems. Thus, the utilization of PMUs has become quite important in the fast monitoring, protection, and even the control of new and complicated distribution systems. However, data quality and communication are the main concerns for synchrophasor applications. This study presents a comprehensive survey on wide-area monitoring systems (WAMSs), PMUs, data quality, and communication requirements for the main applications of PMUs in a modern and smart distribution system with a variety of energy resources and loads. In addition, the main challenges for PMU applications as well as opportunities for the future use of this intelligent device in distribution systems will be presented in this paper.
Neural Network Based Model Comparison for Intraday Electricity Price Forecasting
Authors: Oksuz Ilkay , Ugurlu Umut
Published: November 2019

The intraday electricity markets are continuous trade platforms for each hour of the day and have specific characteristics. These markets have shown an increasing number of transactions due to the requirement of close to delivery electricity trade. Recently, intraday electricity price market research has seen a rapid increase in a number of works for price prediction. However, most of these works focus on the features and descriptive statistics of the intraday electricity markets and overlook the comparison of different available models. In this paper, we compare a variety of methods including neural networks to predict intraday electricity market prices in Turkish intraday market. The recurrent neural networks methods outperform the classical methods. Furthermore, gated recurrent unit network architecture achieves the best results with a mean absolute error of 0.978 and a root mean square error of 1.302. Moreover, our results indicate that day-ahead market price of the corresponding hour is a key feature for intraday price forecasting and estimating spread values with day-ahead prices proves to be a more efficient method for prediction.
Numerical Investigation on Heat-Transfer and Hydromechanical Performance inside Contaminant-Insensitive Sublimators under a Vacuum Environment for Spacecraft Applications
Authors: Gao Lijun , Li Yunze , Xu Huijuan , Zhang Xin , Yuan Man , Ning Xianwen
Published: November 2019

The contaminant-insensitive sublimator (CIS) is a novel water sublimator in development, which uses two porous substrates to separate the sublimation point from the pressure-control point and provide long-life effective cooling for spacecraft. Many essential studies need to be carried out in the field. To overcome the reliability issues such as ice breakthrough caused by large temperature or pressure differences, the CIS development unit model, the mathematical models of heat and mass transfer and the evaluation coefficient have been established. Numerical investigations have been implemented aiming at the impacts of physical properties of porous substrate, physical properties of working fluid, orifice layouts and orifice-structure parameters on the characteristics of flow field and temperature field. The numerical investigation shows some valuable conclusion, such as the temperature uniformity coefficient at the bottom surface of the large pore substrate is 0.997669 and the pressure uniformity coefficient at the same surface is 0.85361267. These numerical results can provide structure and data reference for the CIS design of lunar probe or spacesuit.
Odd/Even Order Sampling Soft-Core Architecture Towards Mixed Signals Fourth Industrial Revolution (4IR) Applications
Authors: Mfana Madodana , Hasan Ali N. , Ahmed Ali
Published: November 2019

Digitization is at the center of fourth industrial revolution (4IR) with previously analog systems being digitized through an analog-to-digital converter. In addition, 4IR applications such as fifth generation (5G) Cellular Networks Technology and Cognitive Electronic Warfare (EW) at some point interface digitally through an analog-to-digital converter. Efficient use of digital resources such as memory, largely depends on the signal sampling design of analog-to-digital converters. Existing even order sampling has been found to perform better than traditional sampling techniques. Research on the efficiency of a digital interface with a 4IR platform is still in its infancy. This paper presents a performance study of three sampling techniques: the proposed new and novel odd/even order sampling architecture, existing Mod-∆, and traditional 1st order delta-sigma, to address this. Step-size signal-to-noise (SNR), dynamic range, and sampling frequency are also studied. It was found that the proposed new and novel odd/even order sampling achieved an SNR performance of 6 dB in comparison to 18 dB for Mod-∆. Sampling frequency findings indicated that the proposed new and novel odd/even order sampling achieved a sampling frequency of 2 kHz in comparison to 8 kHz from a traditional 1st order sigma-delta. Dynamic range findings indicated that the proposed odd/even order sampling has achieved a dynamic range of 1.088 volts/ms in comparison to 1.185 volts/ms from a traditional 1st order sigma-delta. Findings have indicated that the proposed odd/even order sampling has superior SNR and sampling frequency performances, while the dynamic range is reduced by 8%.
Theoretical and Experimental Study to Determine Voltage Violation, Reverse Electric Current and Losses in Prosumers Connected to Low-Voltage Power Grid
Authors: Torres Igor Cavalcante , Negreiros Gustavo F. , Tiba Chigueru
Published: November 2019

The impact of PV generation distributed in a low voltage transmission line depends on many factors: The distribution lines and PV generators characteristics, its location, operational control, local meteorological conditions, electricity consumption profile, and the electricity cost variation. An atypical and challenging behavior of photovoltaic distributed generation (DG) insertion in consumer units (CUs), implies in some circumstances, as the reverse directionality of the power flow between the load equipped with a photovoltaic system generator and the electrical grid, when a CU contains a distributed generation and low power consumption, the power flow will be directed to the power electric grid. In this work, the modeling of a low-voltage real feeder was performed, setting the variables of the system under real operating conditions. As result, voltage levels variability throughout the feeder, the electrical losses, and the asymmetry between the phases were observed. Through simulation scenarios, the occurrence of voltage increase under different penetration scenarios of distributed generation was verified and there was a 10% increase in reference voltage as well as the occurrence of higher electrical losses by reverse current, reaching 1200% more with a DG penetration, in the massive presence of the photovoltaic generator. The mitigatory action used in this work was able to attenuate the negative impacts to the feeder circuit, ensuring the integrity grid and the consumer unit.
The Development of Global Women’s Rights and Improvements in Reproductive Health Intervention Access of Females with Different Socio-Economic Status
Authors: Yuan Bocong , Li Jiannan , Wang Zhaoguo
Published: November 2019

Female’s access to reproductive health intervention has experienced dramatic change with the development of women’s rights across the world. However, the influence of the development of global women’s rights on reproductive health intervention access differs by place of residence and by the socio-economic characteristics of educational attainment and income levels. As a response to it, this study investigates the influence of the development of global women’s rights on contraceptive intervention access of females from different places of residence (rural/urban areas), with different educational attainment and income levels. Using multi-source data from World Health Organization (WHO), Inter-Parliament Union (IPU), International Labor Organization (ILO), and United Nations Educational, Scientific and Cultural Organization (UNESCO), empirical results show that the development of women’s rights generally improves female’s contraceptive intervention access around the world, and especially benefits females in rural areas, with a lower educational level, and in the medium or low-income stratum. The development of global women’s rights thus contributes to the social equity of healthcare access for females.
Increased Heart Rate during Walk Test Predicts Chronic-Phase Worsening of Renal Function in Patients with Acute Myocardial Infarction and Normal Kidney Function
Authors: Ogura Asami , Izawa Kazuhiro P. , Tawa Hideto , Kureha Fumie , Wada Masaaki , Kanai Masashi , Kubo Ikko , Yoshikawa Ryohei , Matsuda Yuichi
Published: November 2019

Chronic-phase worsening renal function (WRF) in patients with acute myocardial infarction (AMI) has been associated with poor prognosis. However, there is no consensus on either the method of prevention or the cause. The aim of this study was to determine factors predictive of chronic-phase WRF from the viewpoint of circulatory dynamics response to exercise during hospitalization of AMI patients without renal dysfunction on admission. We studied 186 consecutively AMI patients who underwent the 200-m walk test. Chronic-phase WRF was defined as a 20% decrease in estimated glomerular filtration rate (eGFR) from baseline to 8–10 months after AMI onset. Heart rate (HR) and systolic blood pressure recorded during the 200-m walk test were evaluated as circulatory dynamics responses. In total, 94 patients were enrolled. Multiple linear regression analysis showed that ΔHR (peak-rest) associated significantly with ΔeGFR (β = 0.427, p = 0.018). The receiver operating characteristic curve of ΔHR to predict chronic-phase WRF showed an area under the curve of 0.77, with a cut-off value of 22.0 bpm having a 95% sensitivity and 55% specificity. Among circulatory dynamics responses during exercise in the acute phase after AMI, ΔHR was an independent predictor of chronic-phase WRF.
Length of Hospital Stay for Osteoarthritic Primary Hip and Knee Replacement Surgeries in New Zealand
Authors: Lao Chunhuan , Lees David , Patel Sandeep , White Douglas , Lawrenson Ross
Published: November 2019

This study aims to explore the length of stay (LOS) of publicly funded osteoarthritic primary hip and knee replacement surgeries in New Zealand. Patients with osteoarthritis who underwent publicly funded primary hip and knee replacement surgery in 2005–2017 were included. We have identified 53,439 osteoarthritic primary hip replacements and 50,072 osteoarthritic primary knee replacements. LOS has been reduced by almost 40% over the last 13 years. Logistic regression showed that women, Māori, Pacific and Asian patients, older patients, people with more comorbidities and those having opiates on discharge and patients in earlier years were more likely to have extended LOS following hip replacements and knee replacements. Regional differences were noted in LOS between the Waitemata District Health Board (DHB) compared to Tairāwhiti DHB where patients were the most likely to have a LOS of more than 5 days after hip and knee replacements. LOS after hip and knee replacements has been reduced dramatically. Women, Māori, Pacific and Asian patients, older patients and people with more comorbidities are more likely to have extended LOS. Patients dispensed opiates on discharge had a longer LOS. There are great geographical variations in LOS for primary hip and knee surgeries in New Zealand.
Practitioners’ Views on Nicotine Replacement Therapy in Pregnancy during Lapse and for Harm Reduction: A Qualitative Study
Authors: Thomson Ross , McDaid Lisa , Emery Joanne , Phillips Lucy , Naughton Felix , Cooper Sue , Dyas Jane , Coleman Tim
Published: November 2019

Many countries, including the UK, recommend nicotine replacement therapy (NRT) for smoking cessation during pregnancy. However, adherence to NRT is generally low, smoking lapse or relapse is common and using NRT to reduce the harm from the number of cigarettes smoked is only advocated in non-pregnant smokers. Two focus groups were conducted with 13 professionals involved in antenatal stop smoking services (SSS). The data were analysed thematically. Two themes were extracted that describe health professionals’ attitudes towards using NRT either during lapses or to reduce smoking in women who cannot quit (harm reduction). These are presented around a social–ecological framework describing three hierarchical levels of influence within smoking cessation support: (1) Organizational: providing NRT during lapses could be expensive for SSS though harm reduction could result in services helping a wider range of clients. (2) Interpersonal: participants felt using NRT for harm reduction was not compatible with cessation-orientated messages practitioners conveyed to clients. (3) Individual: practitioners’ advice regarding using NRT during smoking lapses varied; many were generally uncomfortable about concurrent smoking and NRT use and had strong reservations about recommending NRT when smoking during all but the briefest lapses. Further evidence is required to guide policy and practice.
The Impact of Opium Abuse on Lipid Profile in Patients with Diabetes: A Systematic Review and Meta-Analysis
Authors: Ojo Omorogieva , Wang Xiao-Hua , Ojo Osarhumwese Osaretin , Ibe Jude
Published: November 2019

There is an increasing prevalence of diabetes worldwide and substance abuse has been observed as a problem among some people with diabetes. Therefore, there is an urgent need to understand the association between unhealthy drug use including the abuse of opium and clinical outcomes including its impact on lipid profile in patients with diabetes as the presence of these conditions can increase the risk of cardiovascular morbidity and mortality. Aim: This was a systematic review and meta-analysis which evaluated the impact of opium abuse on lipid profile in patients with diabetes. Method: This systematic review was conducted in line with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Three databases (Embase, PubMed, and PsycINFO) plus Google Scholar were searched for relevant articles from database inception to 18 July 2019 based on the Population, Intervention, Comparator, and Outcomes (PICO) framework. The studies included were based on a set of inclusion and exclusion criteria including patients with diabetes who abused opium. Articles were evaluated for risk of bias and the meta-analysis was conducted using Revman. Results: Six articles that met the criteria were included in the systematic review and meta-analysis. The type of substance abused was opium in all the studies. The results of the meta-analysis showed that opium abuse significantly (P = 0.01) lowered total cholesterol compared to control with a mean difference of −0.17 (95% CI, −0.29, −0.04) in patients with diabetes. With respect to high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and body mass index, the differences were not statistically significant (P > 0.05) between those who abused opium compared with the control. Nutritional deficiencies, weight loss and lipid dysregulation due to liver dysfunction which are found in people who abuse substances may explain the findings of the current review with respect to lipid profile in patients with diabetes who abuse opium compared with the control. Conclusion: The findings of this systematic review and meta-analysis have shown that opium abuse significantly decreased total cholesterol (P < 0.05) in patients with diabetes. However, the effect of opium abuse on HDL cholesterol, triglycerides, body mass index (BMI) and LDL cholesterol in these patients were not statistically significant (P > 0.05) compared with the control. This result has public health significance in terms of ensuring the promotion of adequate nutritional intake in patients with diabetes who abuse opium.
Racial/Ethnic Disparities in US Adolescents’ Dietary Quality and Its Modification by Weight-Related Factors and Physical Activity
Authors: Xu Furong , Cohen Steven A. , Greaney Mary L. , Hatfield Disa L. , Greene Geoffrey W.
Published: November 2019

There are well-known disparities in the prevalence of obesity across racial-ethnic groups, although the behavioral and psychological factors driving these disparities are less well understood. Therefore, the objectives of this study were: (1) to examine differences in dietary quality by race/ethnicity and weight-related variables [body mass index (BMI), weight loss attempt, and weight dissatisfaction] and physical activity (PA) using the Health Eating Index-2015 (HEI-2015); and (2) to investigate the interactions and independent associations of race/ethnicity, weight-related variables and PA on dietary quality. Data for adolescents aged 12–19 years (n = 3373) were abstracted from the 2007–2014 National Health and Nutrition and Examination Survey and analyzed using multiple PROC SURVEYREG, adjusting for demographics and accounting for complex sampling. Analyses determined that Hispanic males had better overall HEI-2015 scores than non-Hispanic whites (48.4 ± 0.5 vs. 45.7 ± 0.6, p = 0.003) or blacks (48.4 ± 0.5 vs. 45.5 ± 0.5, p < 0.001). Hispanic females also had better dietary quality than non-Hispanic whites (50.2 ± 0.4 vs. 47.5 ± 0.5, p < 0.001) and blacks (50.2 ± 0.4 vs. 47.1 ± 0.5, p < 0.001). Meeting the PA recommendation modified racial/ethnic differences in dietary quality for females (p = 0.011) and this was primarily driven by the associations among non-Hispanic white females (ΔR2 = 2.6%, p = 0.0004). The study identified racial/ethnic and gender differences among adolescents in factors that may promote obesity. Results may be useful for obesity prevention efforts designed to reduce health disparities in adolescents.
Implementation and Long-Term Outcomes of Organisational Health Literacy Interventions in Ireland and The Netherlands: A Longitudinal Mixed-Methods Study
Authors: Kaper Marise , Sixsmith Jane , Meijering Louise , Vervoordeldonk Janine , Doyle Priscilla , Barry Margaret M. , de Winter Andrea F. , Reijneveld Sijmen A.
Published: November 2019

Organisational Health Literacy (OHL)-interventions are needed to overcome health inequality. OHL-interventions have successfully identified communication barriers at the organisational level, but evidence is limited on the extent to which this leads to sustainable organisational change. This study aims to assess the implementation fidelity, moderators (barriers and facilitators), and long-term impact of OHL-interventions in hospitals in Ireland and The Netherlands. We used a longitudinal mixed-methods approach to assess two similar OHL-interventions in one Irish and three Dutch hospitals. The OHL-interventions concerned the improvement of navigation and implementation of health literacy-friendly communication throughout organisations. Participants were 24 hospital employees and 40 older adults who use hospital services. At six, eight, and eighteen months, we assessed the level of implementation, barriers and facilitators, and impact through questionnaires and in-depth semi-structured interviews. After older adults and professionals had identified a number of communication problems, we found that professionals had successfully implemented OHL-interventions to promote navigation and comprehensible communication. Limited resources and variation in organisational structures and procedures were perceived as barriers to implementation. The participation of service users, leadership support, and a stepwise implementation of interventions were perceived to facilitate implementation. In the long term, the OHL-interventions led to system-wide improvements, as shown by better embedding of health literacy policies, enhanced patient engagement, provision of plain language training and comprehensible information. Findings were similar for the two countries. Embedded OHL-interventions resulted in sustainable and system-wide health literacy changes in all four hospitals. Following implementation, OHL-interventions have the potential to promote health equity and empowerment among health service users.
How Is the Confidentiality of Crime Locations Affected by Parameters in Kernel Density Estimation?
Authors: Wang Zengli , Liu Lin , Zhou Hanlin , Lan Minxuan
Published: November 2019

Kernel density estimation (KDE) is widely adopted to show the overall crime distribution and at the same time obscure exact crime locations due to the confidentiality of crime data in many countries. However, the confidential level of crime locational information in the KDE map has not been systematically investigated. This study aims to examine whether a kernel density map could be reverse-transformed to its original map with discrete crime locations. Using the Epanecknikov kernel function, a default setting in ArcGIS for density mapping, the transformation from a density map to a point map was conducted with various combinations of parameters to examine its impact on the deconvolution process (density to point location). Results indicate that if the bandwidth parameter (search radius) in the original convolution process (point to density) was known, the original point map could be fully recovered by a deconvolution process. Conversely, when the parameter was unknown, the deconvolution process would be unable to restore the original point map. Experiments on four different point maps—a random point distribution, a simulated monocentric point distribution, a simulated polycentric point distribution, and a real crime location map—show consistent results. Therefore, it can be concluded that the point location of crime events cannot be restored from crime density maps as long as parameters such as the search radius parameter in the density mapping process remain confidential.
Cytokines in Inflammatory Disease
Authors: Kany Shinwan , Vollrath Jan Tilmann , Relja Borna
Published: November 2019

This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this review, we focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts (e.g., shock, trauma, immune dysregulation, osteoporosis, and/or critical illness).
Interplay between miRNAs and Genes Associated with Cell Proliferation in Endometrial Cancer
Authors: Hermyt Ewelina , Zmarzły Nikola , Grabarek Beniamin , Kruszniewska-Rajs Celina , Gola Joanna , Jęda-Golonka Agnieszka , Szczepanek Katarzyna , Mazurek Urszula , Witek Andrzej
Published: November 2019

Endometrial cancer develops as a result of abnormal cell growth associated with uncontrolled cell proliferation, excessive activation of signaling pathways and miRNA activity. The aim of this study was to determine the expression profile of genes associated with cell proliferation and to assess which miRNAs can participate in the regulation of their expression. The study enrolled 40 patients with endometrial cancer and 10 patients without neoplastic changes. The expression profile of genes associated with cell proliferation and the expression profile of miRNAs were assessed using microarrays. RT-qPCR was performed to validate mRNA microarray results. The mirTAR tool was used to identify miRNAs that regulate the activity of genes associated with cell proliferation. Decreased expression of IGF1 and MYLK, as well as SOD2 overexpression, were observed in endometrial cancer using both mRNA microarrays and RT-qPCR. Microarray analysis showed low levels of NES and PRKCA, but this was only partially validated using RT-qPCR. Reduced activity of MYLK may be caused by increased miR-200c, miR-155 and miR-200b expression. Cell proliferation is disturbed in endometrial cancer, which may be associated with an overexpression of miR-200a, miR-200c, and miR-155, making it a potential diagnostic marker.
Usp10 Modulates the Hippo Pathway by Deubiquitinating and Stabilizing the Transcriptional Coactivator Yorkie
Authors: Gao Yang , Zhang Xiaoting , Xiao Lijuan , Zhai Chaojun , Yi Tao , Wang Guiping , Wang Enlin , Ji Xiaohui , Hu Liangchang , Shen Guangshuang , Wu Shian
Published: November 2019

The Hippo signaling pathway is an evolutionarily conserved regulator that plays important roles in organ size control, homeostasis, and tumorigenesis. As the key effector of the Hippo pathway, Yorkie (Yki) binds to transcription factor Scalloped (Sd) and promotes the expression of target genes, leading to cell proliferation and inhibition of apoptosis. Thus, it is of great significance to understand the regulatory mechanism for Yki protein turnover. Here, we provide evidence that the deubiquitinating enzyme ubiquitin-specific protease 10 (Usp10) binds Yki to counteract Yki ubiquitination and stabilize Yki protein in Drosophila S2 cells. The results in Drosophila wing discs indicate that silence of Usp10 decreases the transcription of target genes of the Hippo pathway by reducing Yki protein. In vivo functional analysis ulteriorly showed that Usp10 upregulates the Yki activity in Drosophila eyes. These findings uncover Usp10 as a novel Hippo pathway modulator and provide a new insight into the regulation of Yki protein stability and activity.
Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion
Authors: Al-Koussa Houssam , Al-Haddad Maria , Abi-Habib Ralph , El-Sibai Mirvat
Published: November 2019

Purpose: Colorectal cancer (CRC) is the third most common type of cancer worldwide, and it represents over half of all gastrointestinal cancer deaths. Knowing that cancer cells have a high proliferation rate, they require high amounts of amino acids, including arginine. In addition, several tumor types have been shown to downregulate ASS-1 expression, becoming auxotrophic for arginine. Therefore, Arginine deprivation is one of the promising therapeutic approaches to target cancer cells. This can be achieved through the use of a recombinant human arginase, HuArgI(Co)-PEG5000, an arginine degrading enzyme. Methods: In this present study, the cytotoxic effect of HuArgI(Co)-PEG5000 on CRC cell lines (HT-29, Caco-2, Sw837) is examined though cytotoxicity assays. Wound healing assays, invasion assays, and adhesion assays were also performed to detect the effect on metastasis. Results: Wound healing and invasion assays revealed a decrease in cell migration and invasion after treatment with arginase. Cells that were treated with arginase also showed a decrease in adhesion, which coincided with a decrease in RhoA activation, demonstrated though the use of a FRET biosensor to detect RhoA activation in a single cell assay, and a decrease in MMP-9 expression. Treating cells with both arginase and L-citrulline, which significantly restores intracellular arginine levels, reversed the effect of HuArgI(Co)-PEG5000 on cell viability, migration, and invasion. Conclusion: We can, therefore, conclude that colorectal cancer is partially auxotrophic to arginine and that arginine depletion is a potential selective inhibitory approach for motility and invasion in colon cancer cells.
Molecular Cavity Topological Representation for Pattern Analysis: A NLP Analogy-Based Word2Vec Method
Authors: Guo Dongliang , Wang Qiaoqiao , Liang Meng , Liu Wei , Nie Junlan
Published: November 2019

Cavity analysis in molecular dynamics is important for understanding molecular function. However, analyzing the dynamic pattern of molecular cavities remains a difficult task. In this paper, we propose a novel method to topologically represent molecular cavities by vectorization. First, a characterization of cavities is established through Word2Vec model, based on an analogy between the cavities and natural language processing (NLP) terms. Then, we use some techniques such as dimension reduction and clustering to conduct an exploratory analysis of the vectorized molecular cavity. On a real data set, we demonstrate that our approach is applicable to maintain the topological characteristics of the cavity and can find the change patterns from a large number of cavities.
Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus
Authors: Ma Kongyang , Du Wenhan , Wang Xiaohui , Yuan Shiwen , Cai Xiaoyan , Liu Dongzhou , Li Jingyi , Lu Liwei
Published: November 2019

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive autoantibody production and multi-organ involvement. Although the etiology of SLE still remains unclear, recent studies have characterized several pathogenic B cell subsets and regulatory B cell subsets involved in the pathogenesis of SLE. Among pathogenic B cell subsets, age-associated B cells (ABCs) are a newly identified subset of autoreactive B cells with T-bet-dependent transcriptional programs and unique functional features in SLE. Accumulation of T-bet+ CD11c+ ABCs has been observed in SLE patients and lupus mouse models. In addition, innate-like B cells with the autoreactive B cell receptor (BCR) expression and long-lived plasma cells with persistent autoantibody production contribute to the development of SLE. Moreover, several regulatory B cell subsets with immune suppressive functions have been identified, while the impaired inhibitory effects of regulatory B cells have been indicated in SLE. Thus, further elucidation on the functional features of B cell subsets will provide new insights in understanding lupus pathogenesis and lead to novel therapeutic interventions in the treatment of SLE.
Renal Tubular Glucagon-Like Peptide-1 Receptor Expression Is Increased in Early Sepsis but Reduced in Chronic Kidney Disease and Sepsis-Induced Kidney Injury
Authors: Choi Jae Hyun , Kim Seung Jung , Kwon Soon Kil , Kim Hye-Young , Jeon Hyunjung
Published: November 2019

Acute kidney injury (AKI) is common in patients with sepsis and causes renal ischemia. Glucagon-like peptide-1 (GLP-1) protects the vascular system and the kidney, and GLP-1 receptor (GLP-1R) is expressed in the kidney. Renal GLP-1R activity is decreased in chronic kidney disease (CKD), but is increased by the inflammatory response; however, the effect of AKI on GLP-1R expression is unknown. We investigated the role of GLP-1 by assessing GLP-1R expression in the renal cortex in animals with AKI-related sepsis, CKD, and CKD-with-sepsis. We generated a model of CKD by 5/6 nephrectomy, and sepsis induced by cecal perforation, in male Sprague–Dawley rats. We compared renal GLP-1R expression at 3, 6, 12, 24, and 72 h after cecal perforation, and in CKD and CKD-with-sepsis. We performed blood and urine tests, western blotting (WB), and immunohistochemistry (IHC) to assay GLP-1R expression in renal tubules. The CKD-with-sepsis group showed the lowest kidney function, urine volume, and serum glucose and albumin levels. GLP-1R expression in renal tubules was decreased at 3 h, increased at 24 h, and decreased at 72 h after sepsis induction. GLP-1R expression was decreased at 8 weeks after CKD and was lowest in the CKD-with-sepsis group. The WB results were verified against those obtained by IHC. GLP-1R expression in renal tubules is increased in early sepsis, which may explain the protective effect of endogenous GLP-1 against sepsis-related inflammation.