bluuebunny/crossref_metadata_2025 huggingface dataset:
Audiodescrição em programações televisivas no Brasil: uma análise do cenário atual
Authors: Gomes Pereira Beatriz Regina , Da Rocha Schuster Helena , Negrini Michele
Published: December 2022

A audiodescrição tornou-se um recurso obrigatório nas programações de televisão digital no Brasil em julho de 2011. Determinada pela portaria n° 188, de 2010, a legislação exigia que as emissoras de TV aberta deveriam exibir uma quantidade mínima estabelecida de horas semanais obrigatórias de conteúdo com audiodescrição, que aumentaria progressivamente com o passar dos anos. Em 2020, as emissoras já deveriam transmitir, pelo menos, 20 horas semanais de suas grades com o recurso. Sendo assim, para além de promover uma reflexão sobre a audiodescrição em sociedade, o objetivo principal do presente artigo é analisar se no contexto atual as referidas obrigatoriedades estão sendo de fato cumpridas na TV aberta brasileira e de que forma o recurso está sendo oferecido. Para isso, analisamos as programações da Band RS (Rio Grande do Sul) e da Record RS durante uma semana, do dia 28/02/2022 até o dia 06/03/2022.
Os Centros de Atenção Psicossocial no tratamento de usuários de álcool e outras drogas
Authors: Silva Maria Isabel Félix da , Araújo Queiroz Maria Eulália de , Lopes Isadora Varela , Pachú Clésia Oliveira
Published: December 2022

INTRODUÇÃO:O uso de substâncias psicoativas é um fenômeno em evidência desde os primórdios da humanidade, estando sempre em crescimento. O uso continuado pode desencadear no sujeito um quadro de dependência, levando-o a necessitar de cuidados especializados. Na atualidade, conta-se com os Centros de Atenção Psicossocial (CAPS) para assistência psicossocial. OBJETIVO: Analisar os Centros de atenção psicossocial no tocante ao tratamento de usuários de álcool e outras drogas. METODOLOGIA: Trata-se de uma revisão narrativa da literatura, executada mediante busca em bancos de dados científicos como o Periódicos Capes, PePSIC e Google Acadêmico. Foram selecionados 17 artigos para integrar a revisão. RESULTADOS E DISCUSSÃO: A avaliação dos artigos demonstram que os CAPS são serviços essenciais para usuários de drogas e seus responsáveis, pois dispõem de intervenções em saúde mental que viabilizam um atendimento humanizado aos usuários. Os profissionais, em especial o psicólogo, inseridos na rede de saúde realizam intervenções visando a prevenção de agravos e promoção da saúde em nível individual e coletivo, com uma conduta ética frente às especificidades de cada usuário. A família é o principal instrumento que viabiliza a recuperação do adicto, mas também demanda cuidados específicos, devido à sobrecarga emocional fomentada pelos cuidados dispensados ao membro adicto. CONSIDERAÇÕES FINAIS: Faz-se necessário novos estudos que desvelem os fatores desencadeadores da iniciação e adesão ao uso de drogas visando melhorias nas intervenções dos profissionais do Sistema Único de Saúde, no tocante ao usuário, à família e à comunidade. 

PALAVRAS-CHAVE: Centro de atenção psicossocial; Toxicomania; Programa de saúde mental.
Escola como Agente de Saúde
Authors: Varela Lopes Isadora , Oliveira Pachú Clésia
Published: December 2022

A inserção da escola como agente de saúde se revela como fator importante para a qualidade de vida estudantil e dos profissionais inseridos no ambiente escolar. O acesso à saúde junto à educação são componentes indispensáveis na prevenção de doenças e promoção da saúde no âmbito das instituições de ensino. Objetivou-se analisar o ambiente escolar no tocante as intervenções de saúde promovidas no meio escolar. A presente pesquisa foi realizada nos meses de julho e agosto de 2022, utilizando-se como fonte de dados o Google Acadêmico e PePSIC. Foram selecionados 15 artigos para integrar a revisão. Os resultados obtidos por meio da avaliação dos artigos demonstram que a escola representa espaço fundamental para promoção de intervenções de saúde. Os psicólogos, junto a uma equipe multiprofissional, mostram-se indispensáveis na promoção de saúde e qualidade de vida no interior do espaço escolar. Pode-se concluir que a representação da escola reflete um importante ponto de encontro entre saúde e educação, além de serem espaços importantes para práticas e vivências em saúde, tornando a escola um dos principais agentes de promoção à saúde. Assim, faz-se necessário a implementação de mais profissionais da saúde no interior da escola, em especial psicólogos. Fica demonstrado ser indispensável a inserção de intervenções de saúde em mais escolas, com o intuito de mais indivíduos terem acesso à prevenção de doenças e promoção da saúde na escola.
insurreição escrava de 1838 fruto da instabilidade política/econômica e senhorial [?]
Authors: Souza Alan de Carvalho
Published: December 2022

O presente artigo aborda a insurreição escrava de 1838 ocorrida na freguesia de Paty do Alferes como resultante da instabilidade política/econômica e senhorial da década de 1830. Apresentando-a por meio do conhecimento da senzala do debate político existente que proporcionou a articulação dos escravizados para o melhor proveito da inconstância do período. Diferentemente dos estudos que analisaram a rebelião, este trabalho apresenta novo documento, o qual refuta o motivo de ter sido a morte de um escravizado e a suposta “desordem” existente na escravaria do capitão-mor Manuel Francisco Xavier a razão pela fuga, além de apresentar um grande número de sublevados que continuaram nas matas da região após o embate e captura pela guarda nacional.
Pharmacogenomics—a New Frontier for Individualized Treatment of Parkinson’s
Disease
Authors: Liu Jia-Si , Chen Ying , Shi Dan-Dan , Zhang Bao-Rong , Pu Jia-Li
Published: December 2022

Background:

Parkinson’s disease (PD) is the second most common neurodegenerative disease
with a significant public health burden. It is characterized by the gradual degeneration of dopamine
neurons in the central nervous system. Although symptomatic pharmacological management remains
the primary therapeutic method for PD, clinical experience reveals significant inter-individual
heterogeneity in treatment effectiveness and adverse medication responses. The mechanisms behind
the observed interindividual variability may be elucidated by investigating the role of genetic variation
in human-to-human variances in medication responses and adverse effects.

Objective:

This review aims to explore the impact of gene polymorphism on the efficacy of antiparkinsonian
drugs. The identification of factors associated with treatment effectiveness variability might
assist the creation of a more tailored pharmacological therapy with higher efficacy, fewer side outcomes,
and cheaper costs.

Methods:

In this review, we conducted a thorough search in databases such as PubMed, Web of Science,
and Google Scholar, and critically examined current discoveries on Parkinson's disease pharmacogenetics.
The ethnicity of the individuals, research methodologies, and potential bias of these
studies were thoroughly compared, with the primary focus on consistent conclusions.

Results:

This review provides a summary of the existing data on PD pharmacogenetics, identifies its limitations,
and offers insights that may be beneficial for future research. Previous studies have investigated
the impact of gene polymorphism on the effectiveness and adverse effects of levodopa. The trendiest
genes are the COMT gene, DAT gene, and DRD2 gene. However, limited study on other anti-Parkinson's
drugs has been conducted.

Conclusion:

Therefore, In order to develop an individualized precision treatment for PD, it is an inevitable
trend to carry out multi-center, prospective, randomized controlled clinical trials of PD pharmacogenomics
covering common clinical anti-PD drugs in large, homogeneous cohorts.
Preventive Effects of Achillea Millefolium, Rosa Damascena and Origanum
Majorana Hydroalcoholic Extracts on Breast Cancer in Female Mice
Authors: Nabatchian Fariba , Ashtiani Mojtaba , Teimourpour Amir , Davoudi Negin , Niknam Sara , Afrisham Reza
Published: December 2022

Introduction:

Breast cancer is overall considered the second most frequently recognized
cancer worldwide. Several studies have recently reported the antitumoral properties of some
medicinal herbs such as Yarrow (Achillea millefolium), Marjoram (Origanum majorana), and Rose
(Rosa damascena Mill L). Therefore, the current study aimed to evaluate the effect of the
hydroalcoholic extract of these plants on breast cancer prevention in female mice.

Methods:

Mice were classified into five ten‐mice groups: normal control (untreated group), tumor
group (treated with 4T1 cells), and treatment groups (treated with 4T1 cells+ Yarrow or Rose and
Marjoram plants). Then, the levels of cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen
(CEA), superoxide dismutase (SOD), and total antioxidants were determined. Finally, the tumor size
was evaluated.

Results:

The hydroalcoholic extract of Yarrow herb significantly decreased the levels of CA-15-3
and CEA (P-value = 0.008 and P-value = 0.018, respectively). In addition, hydroalcoholic extracts of
Yarrow, Rose, and Marjoram plants significantly reduced tumor size in comparison with the tumor
group (P-value < 0.001 for Yarrow, and P-value = 0.004 for Rose and Marjoram plants). Yarrow
herb had the significantly highest effect on tumor size in comparison with Rose and Marjoram plants
(P-value = 0.011 for both plants). However, no significant differences were found among the groups
treated with the plants in comparison with the tumor mice in terms of SOD and total antioxidants (Pvalue
> 0.05).

Conclusion:

Our findings revealed that A. millefolium had the greatest antitumor effects on mice
with breast cancer in comparison with O. majorana and R. damascena herbs. However, more
complementary studies are needed in this regard.
High Value Compounds and Bioactivity of Rice Bran, Rice Bran Protein:
A Review
Authors: Kalita Pratap , Ahmad Abdul Baquee , Sen Saikat , Deka Bhargab , Hazarika Quri Kiran , Kapil Manas Jyoti , Pachuau Lalduhsanga
Published: December 2022

Rice bran and rice bran protein are important sources of minerals, energy, and vitamins.
Other bioactive compounds are abundantly available to exert therapeutical activity. Healthpromoting
activities of high-value compounds of rice bran were significant, as observed in recent
studies. A variety of bioactive components present in rice bran and rice bran extract are responsible
to exhibit therapeutical potential like chemopreventive, cardioprotective, hepatoprotective,
immunomodulatory, neuroprotective, and lipid-lowering activity. Several bioactivity representative
compounds like γ-oryzanol, ferulic acid, caffeic acid, tricin, protocatechuic acid, vanillic acid,
coumaric acid, phytic acid, isoferulic acid, gallic acid, γ-amino butyric acid, sinapic acid, saturated
and unsaturated fatty acids, vitamin E complexes, β-sitosterol, stigmasterol, campesterol,
cyanidin-3-glucoside, peonidin-3-glucoside, quercetin, rutin, kaemferol, β-carotene, lutein, vitamin
B and lycopene are known to display significant health benefits. The bioactive components
produced therapeutical effects by regulation of different mechanisms like increasing faecal excretion,
reducing oxidative stress, reducing the level of malondialdehyde (MDA), regulation of
NF-kb activation, reduction of proinflammatory cytokines production, suppression of SREBP-1,
reduction in the expression of anti-apoptotic protein Bcl-2, elevated the expression of proapoptotic
protein Bax, up-regulating P53 expression and suppressing COX-2. Several research
engines like PubMed, google scholar, science direct, etc. were used to collect the data on the mentioned
keywords. Recent scientific works were included in this article. In this review paper, we
profiled the high-value compounds and focused on their antioxidant, anti-hyperlipidemic, antidiabetic,
and anticancer activity with their possible mechanism of action.
Pekerja Rumah Tangga dan Organisasi Masyarakat Sipil: Persoalan Tentang Ruang Kebebasan Sipil di Indonesia
Authors: Anwar Violetta Lovenika Nur , Minata Bella Anggie , Pratama Andhika Theo , Rozalinna Genta Mahardhika
Published: December 2022

Domestic workers or often known as household assistants or domestic helpers are no stranger to their existence in the lives of Indonesian people, both in rural and urban areas. Domestic worker or abbreviated as PRT is a job where the worker offers services to the employer to do various household chores, such as washing, cooking, cleaning the house, caring for children, and other household chores. The existence of domestic workers as informal workers or domestic workers in the household has not been accompanied by clear and concrete legal rules to recognize and protect domestic workers in their work, so that domestic workers often become subjects that are ignored and underestimated, from a status that is marginal and does not exist, not even rare. Receiving treatment that is detrimental to domestic workers, such as violations of rights, sexual harassment, to torture or violence perpetrated by employers against domestic workers. Against the backdrop of cases of violations of domestic workers' rights, domestic workers have begun to have the courage to strive for their rights to be protected by the state. Efforts to seek decent work for domestic workers have been contained in the Domestic Workers Bill and the existence of ILO Convention No.189. However, until now the Indonesian state government has not ratified the Domestic Workers Bill to become the Domestic Workers Law. Therefore it requires the participation of all elements of the state including the government and civil society. Through Civil Society Organizations (CSOs), it is hoped that they can become a bridge for people's aspirations and voices to push for the ratification of the PPRT Bill. Apart from that, as a democratic country, CSOs are also needed to claim the title of a democratic country for Indonesia so that civic freedoms can be upheld for the sake of achieving people's welfare. Especially for marginalized people like domestic workers.
Gerakan Sosial Akar Tuli Dalam Mengadvokasi Hak Tuli di Kota Malang
Authors: Yahya Wama , Arawindha Ucca
Published: December 2022

The Malang City in Indonesia, declares itself to be inclusive city, but it turns out that there are still many people with disabilities’ – deafness – rights seem not been fulfilled, one of which become the focus of this research. For deaf people, one of their efforts to seek the fulfillment of their rights is to form a collectivity. For that reason, the Akar Tuli was built, with the motive to bring Deaf youth into a forum which allows them to voice their rights. This study aims to determine, analyze and describe how social action of Akar Tuli as a social movement through advocation for the rights of deaf people in Malang City. This research uses the New Social Movement Theory, namely ‘The Identity-Oriented Theory’ that seek the explanation of how this community carries out social movements to achieve their goals by their identity. As a community, there would be a very strong reason for Akar Tuli to keeps them going to carry out various kinds of movements. That is, the fulfillment of the rights of deaf people to the sign language they use to communicate and also as their identity. Sign language is the strengthen for Akar Tuli to socialization and education about the disability rights by collaborate with government or non-government organization in Malang. Furthermore, accessibility is also a keypoint for them. The conclusion is Akar Tuli take social action as social movement that aims to encourage disability awareness in Malang City. Hopefully, the Deaf people have the same rights as a citizen, even though their communicate in different ways.
The Effect of Local Revenue and Balancing Funds on the Economy of Bali Province in 2012-2019
Authors: Pradana Asika Cahyaning Tiwi , Mun’im Akhmad
Published: December 2022

The implementation of Law Number 32 of 2004 concerning regional autonomy required Indonesia to change its economic development system from centralized to decentralized. One form was fiscal decentralization which aimed to promote social welfare and regional independence. However, the economic growth of several regions fluctuated, even though the fiscal decentralization instrument issued by the central government continued to increase. One of the provinces in Indonesia that have implemented a fiscal decentralization policy is Bali. It is categorized as one of the very-good provinces in terms of economic independence, reaching 53 percent, and tent to receive increasing local revenue every year. However, its economy seems to remain relatively high. This study aims to estimate the effect of fiscal decentralization as seen from PAD and balancing funds to the economic growth in districts/cities of Bali Province in 2012-2019. By using panel data regression analysis, this study examines the effect of PAD and balancing funds in the districts/cities of Bali Province and their effects on Bali’s economic growth. This study finds that the best model explaining the influence among those variables is the Fixed Effects Model (FEM) with Seemingly Unrelated Regression (SUR). The results show that the DAU and the combination of the utilization of regional income that includes PAD and other legal regional income have a positive and significant effect on economic growth in the districts/cities of Bali Province. Therefore, optimizing the use of regional revenues, both in the form of PAD and Other Legitimate Regional Revenues, may increase economic growth.
Bloco solo-cimento sustentável com materiais de mudança de fase (PCMs)
Authors: V.B. Dantas  , U.U. Gomes  , E.P. Reis  , A.S. Silva  , C. Jesus  , J.L. Barroso Aguiar
Published: December 2022

No estudo apresentam-se resultados do desenvolvimento de um bloco solocimento com materiais de mudança de fase (PCMs). Realizaram-se três tipos de misturas, no qual duas delas foram efetuadas com materiais de mudança de fase (PCMs) com diferentes percentagens desse material, 3% e 5%, à terceira mistura não foi adicionado qualquer PCM sendo esta uma mistura de referência. Em todas as misturas realizadas do estudo foi acrescentado ao solo 9% de cimento Portland CEM - P II Z-32 e aproximadamente 9,2% de água. Nas misturas do estudo com à exceção da mistura de referência (E1) foi adicionado 10% de areia quartzosa às restantes misturas. Realizaram-se ensaios de granulometria, limite de plasticidade e limite de liquidez, ao solo do estudo.Para cada mistura foram produzidos blocos solo-cimento, sobre os quais foram executados ensaios físicos e mecânicos. Os blocos do estudo foram compactados numa prensa mecânica e a influência da porosidade foi significativa quanto aos valores da sua resistência. Os PCMs introduzidos melhoraram as propriedades térmicas do bloco, mas diminuíram a resistência mecânica.No estudo observaram-se comportamentos mecânicos e físicos distintos nas diferentes composições do solo-cimento com as diferentes percentagens de materiais de mudança de fase. Verificou-se que no bloco com adição de 10% de areia quartzosa e sem PCM a resistência à compressão aumentou em relação ao bloco referência. No caso da adição dos diferentes PCMs houve uma diminuição significativa da resistência mecânica, no entanto superaram os valores mínimos normativos. As misturas com adição dos diferentes PCMs apresentaram valores de condutividade e difusidade térmica inferiores às outras. As propriedades térmicas foram analisadas utilizando sensores e um equipamento de aquisição de dados.
Levantamento estatístico da inspecção, diagnóstico e reparação de revestimentos por pinturas em fachadas rebocadas
Authors: R. Pires  , J. Brito  , B. Amaro  , C. Pereira
Published: December 2022

No presente artigo, expõe-se o estudo estatístico efectuado sobre a patologia de revestimentos por pintura em fachadas rebocadas, realizado com base na inspecção de 105 fachadas pintadas, na área metropolitana de Lisboa, Portugal. Dos 41 edifícios inspeccionados, 88% encontram-se em áreas de desenvolvimento urbano da segunda metade do séc. XX. As fachadas foram seleccionadas por terem, pelo menos, 50% de área pintada sobre reboco e uma anomalia observável. Estudaramse as tipologias de anomalia mais frequentes em revestimentos por pintura, as suas causas mais prováveis, as técnicas e ensaios adequados e técnicas de reparação necessárias, tendo por base a classificação definida no sistema de inspecção, diagnóstico e reparação correspondente. Esse sistema foi desenvolvido para simplificar e facilitar o processo de inspecção. Avaliaram-se também alguns parâmetros condicionantes, permitindo aportar informação sobre as principais sensibilidades deste tipo de revestimento e contribuindo para o conhecimento actual sobre prevenção de anomalia e intervenção sobre as mesmas.
Concreto de alto desempenho utilizando agregados disponíveis na região de Patos de Minas - MG
Authors: G.F. Silva  , C.F. Silva  , G.J. Silva
Published: December 2022

O seguinte trabalho busca avaliar os agregados da região de Patos de Minas - MG, afim de produzir um concreto de alto desempenho. Utilizando o cimento CPV e diferentes teores de sílica ativa, realizando ensaios para caracterizar suas resistências mecânicas. Para determinar a melhor proporção dos agregados, foi feito o estudo do empacotamento dos mesmos. Após definir a melhor proporção dos agregados estudou-se a dosagem do concreto, acrescentando teores de 10, 15 e 20% de sílica ativa. O concreto produzido com teor de 15% de sílica ativa apresentou o melhor resultado de resistência. Apesar do estudo não alcançar oobjetivo de chegar à uma resistência de 80 MPa, conseguiu-se resistência bem próxima do esperado, 76,7 MPa. Contudo, conclui-se que é possível produzir um concreto de alto desempenho com os agregados disponíveis na região
Análise da variabilidade dos preços de construção
Authors: D. Baloi
Published: December 2022

A enorme variabilidade dos preços de construção submetidos pelos empreiteiros nos concursos em Moçambique tem sido uma ocorrência sistemática nos últimos tempos. A variabilidade em si é algo normal num ambiente competitivo, mas a suasignificativa magnitude torna o facto preocupante. Diferenças de preços da ordem de mais de 70% ou mesmo mais de 100% registam-se com frequência. O facto é revelador de algo de anómalo no mercado de construção que urge analisar. Estetrabalho debruça-se sobre a prevalência e magnitude da variabilidade dos preços de construção. Para o efeito, foram realizadas entrevistas com profissionais da construção e recolhidos dados de preços de concurso correspondentes aos últimoscatorze anos. Empregou-se estatística descritiva na análise dos dados com enfoque para o coeficiente de variação, a margem vencedora e a amplitude máxima. A análise permite concluir a prevalência de níveis elevados de variabilidade depreços ao longo dos últimos anos, independentemente da dimensão do projecto. A média do coeficiente de variação é de cerca de 26%, com um máximo de 52% e mínimo de 7%. É de interesse estudar as causas profundas do fenómeno.
Método para análise do risco em estruturas de arrimo em concreto armado
Authors: R.B.C. Cruz  , F.A. Santos  , J.B. Souza  , J.A. Khalil  , R.M.G. Carvalho  , A.M. Filho
Published: December 2022

Muros de arrimo são estruturas de contenção utilizadas para corte e aterro em perfis naturais de solos. Eventualmente, há prejuízo em sua capacidade de carga, desempenho em serviço e a durabilidade nestas estruturas, que podem ser associadas à anomalias e falhas decorrentes de manifestações patológicas, que por sua vez estão intrinsecamente ligadas a solicitações, agentes agressivos,deficiências de projeto e execução. A deteção de falhas e sua severidade, bem como a associação de responsabilidades, são objeto de um processo de inspeção, que levarão a elaboração de um laudo ou parecer, e a análise deste laudo com vistas à Análise do Risco requisitando um posicionamento qualitativo e quantitativo do risco em função de sua severidade, ocorrência e deteção. De tal forma que o objetivo deste trabalho é a avaliação de risco em muros de arrimo em concreto armado. Foram evidenciados seis grupos de patologias, do qual foram expandidas em dezoito falhas possíveis, neste cenário, e analisadas sob o método da ferramenta Failure Mode and Effect Analysis (FMEA). Assim três falhas apontaram grau de risco alto e muito alto cujos fatores preponderantes nessas falhas foram inerentes à presença de umidade e deficiências no sistema drenante.
Avaliação de práticas sustentáveis aplicáveis ao projeto e construção de edificações do setor financeiro
Authors: A.F.E. Lucena  , J.L. Miotto  , L.M. De Mori
Published: December 2022

É significativo o impacto negativo que as ações geradas pelo desenvolvimento humano causam ao meio ambiente. Nesse contexto, a construção civil se destaca, uma vez que exerce grande influência nas atividades produtivas e na economia nacional e mundial. Assim, torna-se necessária a adoção de políticas e práticas voltadas ao desenvolvimento sustentável. Baseado em tais preceitos, o presente estudo teve por objetivo avaliar o grau de sustentabilidade ambiental e aplicabilidade de práticas que podem ser adotadas na construção de edificações relacionadas às instituições financeiras. Para tanto, inicialmente realizou-se uma pesquisa bibliográfica das práticas sustentáveis mais referenciadas na literatura, corroborada pela realização de benchmarks acerca da efetiva utilização de tais estratégias em empreendimentos considerados referências de construções sustentáveis na atualidade. A partir dessas informações, e também por meio das considerações expostas nos regulamentos das certificações ambientais LEED e AQUA-HQE, foi possível avaliar as práticas indicadas. Com base nessa avaliação, concluiu-se que as estratégias mais indicadas para o empreendimento em questão estão relacionadas à coleta e acondicionamento de materiais recicláveis, aproveitamento da iluminação e ventilação natural e arrefecimento evaporativo.
O pós obra em empresas da construção civil
Authors: K.C.C. Alves  , V.Q. Lira  , A.C.L Junior
Published: December 2022

O aparecimento cada vez mais precoce de manifestações patológicas em edificações construídas no período compreendido entre os anos de 2006 e 2014, quando o mercado imobiliário brasileiro experimento período de forte crescimento, se contrapõe as ações das construtoras implementadas à época e voltadas à diferenciação no mercado e à busca pela excelência. Como forma de mitigar os problemas, a monitorização do pós obra assume cada vez mais relevância, pois deve arrefecer os conflitos de relacionamento com os clientes e direcionar as ações de melhorias que previnam a reincidência de patologias. Neste contexto, este trabalho tem como objetivo atualizar o conhecimento sobre o pós obra, a partir de casos de estudo em construtoras, procurando compreender osprincipais elementos característicos de atuação: os procedimentos adotados, os indicadores utilizados, as patologias incidentes e as falhas de gestão. A metodologia do trabalho contemplou pesquisa de natureza descritiva; entrevistas estruturadas e estudo de 30 empreendimentos de dez empresas construtoras da cidade de Recife. Os resultados obtidos indicam que não há padronização do pós venda entre as construtoras, a existência de falhas na escolha e uso dos indicadores de monitorização, a ocorrência expressiva de manifestações patológicas e a pouca utilização dos dados do pós obra para retroalimentar o sistema de produção das edificações.
Aplicação do segundo teorema de Castigliano na solução de estruturas hiperestaticas
Authors: A.M. Ilkiu
Published: December 2022

No presente artigo, apresentam-se estudos de casos de análise de estruturas estaticamente indeterminadas ou hiperestáticas, utiliza-se o segundo teorema de Castigliano e o “Theorem of Last Work” na determinação das constantes hiperestáticas. Consideram-se modelos de estruturas sujeitos a carregamentos diversos onde, as condições de contorno nos apoios externos sugeridos como redundante são identificadas e as incógnitas ou constantes hiperestáticas determinadas. Destacam-se as análises das equações clássicas apresentadas por Timoshenko S.P. e Young D.H. (1965) e das teorias elásticas no desenvolvimento dos modelos matemáticos. Utiliza-se da simulação numérica, através do programa de Elementos Finitos (FEA) Ansys onde, comparam se os resultados numéricos e analíticos que foram obtidos pelas equações do presente trabalho.
Relationship Between TTF-1 Expression and PFS of Pemetrexed-containing Chemotherapy in Non-squamous-NSCLC Patients With and Without Driver Genes
Authors: OKAUCHI SHINICHIRO , MIYAZAKI KUNIHIKO , SHIOZAWA TOSHIHIRO , SATOH HIROAKI , HIZAWA NOBUYUKI
Published: December 2022

Background/Aim: We performed a retrospective study too clarify whether the presence or absence of driver genes affects the relationship between thyroid transcription factor-1 (TTF-1) expression and response to pemetrexed (PEM) in non-squamous non-small cell lung cancer (non-sq-NSCLC) patients. Patients and Methods: We reviewed the medical charts of patients treated with PEM-containing chemotherapy during the period from February 2016 to February 2022 at Mito Medical Center-University of Tsukuba, Ryugasaki Saiseikai General Hospital, and University of Tsukuba Hospital. Results: During the period of the study, 185 driver gene-negative patients negative, and 65 driver gene-positive patients were evaluated. Among the 165 driver gene-negative patients, progression free survival (PFS) of TTF-1-expressing patients treated with PEM-containing chemotherapy was significantly longer compared to that of TTF-1-negative patients. In the analysis of 65 driver gene-positive patients, the PFS of TTF-1-positive patients treated with PEM-containing chemotherapy did not differ significantly from that of TTF-1-negative patients. There was no significant difference in PFS between driver gene-negative and driver gene-positive patients treated with PEM-containing chemotherapy. Comparison between four groups defined according to the presence of driver gene and TTF-1 expression indicated shorter PFS only in ‘driver gene-negative and TTF-1-negative’ patients. Conclusion: In driver gene-positive non-sq NSCLC patients, expression of TTF does not affect the survival outcome of PEM-containing-chemotherapy. In other words, in these patients, second-line or later-line PEM-containing chemotherapy after development of resistance for specific-tyrosine kinase inhibitor could be expected to have the same level of efficacy as first-line PEM containing chemotherapy in driver gene-negative, TTF-1-positive non-sq NSCLC patients.
Prognostic Factors of Cervical Adenocarcinoma With Positive Pelvic Lymph Node Metastases Without Preoperative Lymph Node Enlargement Treated With Radical Hysterectomy
Authors: WATANABE TOSHIAKI , TAMASHIRO NATSUKI , SHIMOJI YUKO , ARAKAKI YOSHIHISA , TAIRA YUSUKE , NAKAMOTO TOMOKO , KUDAKA WATARU , AOKI YOICHI
Published: December 2022

Background/Aim: Pelvic lymph node (LN) metastases are found histopathologically after radical hysterectomy (RH) in some cases of cervical adenocarcinoma with no enlarged LNs on preoperatively. The aim was to clarify whether LN metastasis is a prognostic factor in these patients, and whether any postoperative therapy is advisable. Patients and Methods: Sixty-one patients with stage I-II cervical adenocarcinoma [International Federation of Obstetrics and Gynecology (FIGO) 2008] with no enlarged pelvic LNs on preoperative imaging evaluation who underwent RH at our institution were retrospectively examined for clinicopathological, treatment, and prognosis-related factors. Results: The median age was 47 years. FIGO stages were IB1 in 44 patients, IB2 in 10, IIA in 4, and IIB in 3. Seventeen patients (27.9%) had positive pelvic LNs. The multivariate analysis for both overall (OS) and disease-free (DFS) survival showed only pelvic LN metastasis was an independent prognostic factor. In a multivariate analysis of LN-positive cases, multiple LN metastases was an independent prognostic factor for poorer DFS. OS rates were 100%, 83.3%, and 30.0%, and DFS rates were 85.5%, 83.3%, and 12.5% for patients with no LN metastasis, single metastasis, and multiple metastases, respectively, showing a significant difference. Eight recurrences were observed in 10 patients with multiple node-positive disease, and six (75%) had an intrapelvic recurrence. Conclusion: Among patients who underwent RH for cervical adenocarcinoma with no preoperative enlarged LN and positive pelvic LNs confirmed postoperatively, multiple positive pelvic LNs are an independent poor prognostic factor. Because pelvic recurrence is common, concurrent chemoradiotherapy, possibly using paclitaxel and cisplatin, should be considered as adjuvant therapy.
Real-Time Twitter Data Analysis: A Survey
Authors: Rasul Hakar Mohammed , Jumaa Alaa Khalil
Published: December 2022

Internet users are used to a steady stream of facts in the contemporary world. Numerous social media platforms, including Twitter, Facebook, and Quora, are plagued with spam accounts, posing a significant problem. These accounts are created to trick unwary real users into clicking on dangerous links or to continue publishing repetitious messages using automated software. This may significantly affect the user experiences on these websites. Effective methods for detecting certain types of spam have been intensively researched and developed. Effectively resolving this issue might be aided by doing sentiment analysis on these postings. Hence, this research provides a background study on Twitter data analysis, and surveys existing papers on Twitter sentiment analysis and fake account detection and classification. The investigation is restricted to the identification of social bots on the Twitter social media network. It examines the methodologies, classifiers, and detection accuracies of the several detection strategies now in use.
Physiological and Psychological Effects of Parent-Delivered Traditional Thai Massage in Children With Autism: Protocol for a Randomized Controlled Trial
Authors: Ruan Hui , Eungpinichpong Wichai , Wu Hua , Aonsri Chanada
Published: December 2022

Background

Although many autistic children receive massage as a complementary therapy, it is not included in evidence-based practice for autism because evidence of its efficacy is lacking. Further, prior studies have failed to identify objective indicators of core symptoms or elucidate their mechanisms.

Objective

We developed a parent-delivered traditional Thai massage (TTM) intervention for children with autism, aiming to experimentally determine whether children with autism truly experience positive effects from parent-delivered TTM and determine possible mechanisms of the observed effects.

Methods

A 2-armed, parallel randomized controlled trial was conducted between February 2022 and June 2022. Forty-eight children with autism (aged 7-12 years) were recruited from the Hainan Special Education School and randomly assigned to either a parental TTM or control group at a ratio of 1:1 based on random numbers generated with Online Research Randomizer. The generated sequences were concealed in an opaque envelope. Individuals in the parental TTM group received 16 parent-delivered TTM sessions over 8 weeks at the school’s health room after school, and the control group maintained a normal daily routine. Outcomes were assessed on admission, after 8 weeks, and at a 2-month follow-up and included the effect of massage treatment on autism symptoms, measured with the Autism Treatment Evaluation Checklist score (evaluated by parents and a blinded teacher), physiological parameters (ie, heart rate variability and gait), and the Parenting Stress Index, Fourth Edition–Short Form.

Results

We finished all data collection on June 20, 2022. Data analysis will be started, and we expect to publish results in 2023.

Conclusions

This study will provide further evidence for massage treatment of autism and provide support for family-based care.

Trial Registration

Chinese Clinical Trial Registry ChiCTR2100051355; https://tinyurl.com/3dwjxsw5

International Registered Report Identifier (IRRID)

DERR1-10.2196/41839
Accuracy of Artificial Intelligence–Based Automated Quantitative Coronary Angiography Compared to Intravascular Ultrasound: Retrospective Cohort Study (Preprint)
Authors: Moon In Tae , Kim Sun-Hwa , Chin Jung Yeon , Park Sung Hun , Yoon Chang-Hwan , Youn Tae-Jin , Chae In-Ho , Kang Si-Hyuck
Published: December 2022

BACKGROUND

An accurate quantitative analysis of coronary artery stenotic lesions is essential to make optimal clinical decisions. Recent advances in computer vision and machine learning technology have enabled the automated analysis of coronary angiography.

OBJECTIVE

The aim of this paper is to validate the performance of artificial intelligence–based quantitative coronary angiography (AI-QCA) in comparison with that of intravascular ultrasound (IVUS).

METHODS

This retrospective study included patients who underwent IVUS-guided coronary intervention at a single tertiary center in Korea. Proximal and distal reference areas, minimal luminal area, percent plaque burden, and lesion length were measured by AI-QCA and human experts using IVUS. First, fully automated QCA analysis was compared with IVUS analysis. Next, we adjusted the proximal and distal margins of AI-QCA to avoid geographic mismatch. Scatter plots, Pearson correlation coefficients, and Bland-Altman were used to analyze the data.

RESULTS

A total of 54 significant lesions were analyzed in 47 patients. The proximal and distal reference areas, as well as the minimal luminal area, showed moderate to strong correlation between the 2 modalities (correlation coefficients of 0.57, 0.80, and 0.52, respectively; P<.001). The correlation was weaker for percent area stenosis and lesion length, although statistically significant (correlation coefficients of 0.29 and 0.33, respectively). AI-QCA tended to measure reference vessel areas smaller and lesion lengths shorter than IVUS did. Systemic proportional bias was not observed in Bland-Altman plots. The biggest cause of bias originated from the geographic mismatch of AI-QCA with IVUS. Discrepancies in the proximal or distal lesion margins were observed between the 2 modalities, which were more frequent at the distal margins. After the adjustment of proximal or distal margins, there was a stronger correlation of proximal and distal reference areas between AI-QCA and IVUS (correlation coefficients of 0.70 and 0.83, respectively).

CONCLUSIONS

AI-QCA showed a moderate to strong correlation compared with IVUS in analyzing coronary lesions with significant stenosis. The main discrepancy was in the perception of the distal margins by AI-QCA, and the correction of margins improved the correlation coefficients. We believe that this novel tool could provide confidence to treating physicians and help in making optimal clinical decisions.
Isotretinoin Use in Transmasculine Patients and Its Implication on Chest Masculinization Surgery: Scoping Review of the Literature (Preprint)
Authors: Strock Daniel , Sivesind Torunn E , Dellavalle Robert P , Mundinger Gerhard S
Published: December 2022

BACKGROUND

Acne often worsens in transmasculine patients who are on prolonged testosterone therapy. Isotretinoin is an oral retinoid used in the treatment of severe or refractory cases of acne, but it has the potential to cause delayed wound healing. Transmasculine patients may potentially be prescribed treatment for acne with isotretinoin while also planning to undergo chest masculinization surgery.

OBJECTIVE

This scoping review aims to determine whether isotretinoin has a negative impact on postoperative healing in transmasculine patients undergoing chest masculinization surgery.

METHODS

A scoping review was performed using the PubMed and Ovid databases. A total of 16 publications were selected for inclusion.

RESULTS

Acne tends to peak in transmasculine patients 6 months after initiation of testosterone treatment. Severe cases can be treated with isotretinoin; however, acne may recur once treatment is discontinued, given ongoing hormone therapy. There is little to no evidence in the medical literature regarding perioperative use of isotretinoin specifically among transmasculine patients undergoing chest masculinization surgery. In general, however, recent studies have found no evidence of increased hypertrophic scars or keloids in patients taking isotretinoin.

CONCLUSIONS

Further studies are required to strengthen the current evidence that suggests that isotretinoin does not need to be discontinued before or after incisional or excisional surgeries, including chest masculinization surgery in transmasculine patients.
The Potency of Alpinia galanga as Natural Antioxidant
Authors: Laksmitawati Dian Ratih , Pratami Diah Kartika , Widowati Wahyu , Kusuma Hanna Sari Widya , Wijayanti Cahyaning Riski , Rizal Rizal
Published: December 2022

An antioxidant is a chemical compound that can bind free radicals in the body. Reactive oxidative species (ROS) is a reaction that involves oxygen. ROS consists of free radicals and non-radical ones. The imbalance between ROS and antioxidants can cause oxidative stress, one of the factors contributing to the development of numerous diseases. This study aims to evaluate the possible antioxidant activity of lengkuas extract (LE), which may be employed as a medicine component to reduce ROS. The method that used in this research were total phenolic content, total flavonoid content, 2,2 diphenyl 1 picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), NO scavenging, 2,2′-Azinobis(3-Ethylbenzthiazoline-6-Sulfonate) (ABTS), and ferric reducing antioxidant power (FRAP). The result shows that the TPC of LE was 6.80 ± 0.34 (GAE) µg/mg with gallic acid standard and the TFC was 3.39 ± 0.06 µg/mg by quercetin standard. The IC50 value of LE were 121.20; 87.65; 139.94; 181.09 µg/ml by ABTS, DPPH, NO, and H2O2 assay respectively. The scavenging activity of LE was increased with a higher concentration in every method. In conclusion, Alpinia galanga has the potential as an antioxidant. Thus, it can be widely consumed or used as a mixture in medicine to reduce ROS.
VALIDITY OF WORKSHEET ORIENTED STUDENT FACILITATOR AND EXPLAINING MODEL FOR STUDENTS IN THE TOPIC DYNAMICS OF ROTATION AND BALANCE OF RIGID BODIES
Authors:   Universitas PGRI Sumatera Barat, Veronika Grace , Anaperta Megasyani , Helendra Helendra ,   Universitas PGRI Sumatera Barat
Published: December 2022

The use of teaching materials in the learning process really helps the realization of an active, effective and efficient learning, as well as the discovery of concepts independently by students. One of the efforts to realize this as well as the aim of this research is to develop teaching materials in the form of physics learning worksheet oriented to the Student Facilitator and Explaining learning model which is valid for class XI students in the Science program at SMA Negeri 6 Padang. The type of research used is Research and Development (R&D). The research procedure was a 4-D model namely define, design, develop, and disseminate, but this stage was not carried out due to time constraints. The research instrument used was a validity questionnaire. Furthermore, the data obtained was analyzed to see the validity of the worksheet. The results showed that the Student Facilitator and Explaining oriented worksheet developed was categorized as valid with a percentage of 80.2%. The validity of the worksheet is illustrated by the results of validation by experts on the four aspects of the assessment, namely the appropriateness of the content, language and images, presentation, and graphics. Keyword : Worksheet, Student Facilitator and Explaining, Valid.
Disc Brake Run-Out Detection System
Authors: Raikar Dattaraj , Sadwilkar Omkar
Published: December 2022

Abstract: Disc brakes failure had become a major issue in vehicles these days, some of the common reasons for brake failures are reported to be a disc wobble, as it affects the overall braking, and the wobble caused on disc brakes generates a shudder at the passenger cabin through the brake pedal, which adds to a jagged movement of the vehicle. After carrying out deep research on this issue, an idea was formed to sense the wobble on the disc rotor. So, based on this idea a new concept for the Data Acquisition system is presented, namely: a Brake Disc Run-Out Sensor, which is designed on browser-based simulation software, Tinker-Cad. A Circuit diagram along with a block diagram is displayed and explained, addressing the main idea and objective of this prototype, this system will show the disc brake wobble or run-out data to the driver or controller via a visual indication. In this system, a tilt sensor is used and is interfaced with a microcontroller, every code is explained in detail with comments on each step. This system will increase the overall life of the brake rotor and the vibrations caused on the vehicle will be avoidable up to some extent. Therefore, reducing the maintenance cost of the vehicle
A Study of Importance of Health Benefits in Curcumin
Authors: Kalaiarasi G.
Published: December 2022

Abstract: The present study represents the importance of curcumin which is present in turmeric. Curcumin is belonging to the group of curcuminoids which are natural phenols responsible for turmeric yellow colour. The main constituent of this curcuminoid is it contains enormous number of therapeutic properties such as antioxidant, anti-inflammatory, radio protective, anti-cancer and neuro protective. Curcuminoid is used as dietary supplements, food additives, medical treatment and cosmetics. An average human should consume 2500 mg of curcumin per day to avoid the carcinogenic and cardiovascular defects. Various samples were analysed using improved HPLC method.
Review on Application of Machine Learning in Predicting Mechanical Properties of Metals
Authors: Gaur Prashant Kumar , Singh Shashank , Sharma Sanket , Pundir Mayank Kumar , Sharma Sumit Kumar , Jain Naman
Published: December 2022

Abstract: It is known that there are several types of metals present in real world in which we are supposed to choose the metal according to our need. Also, they possess several types of mechanical properties and according to these properties we can further proceed. In this work we use machine learning for calculating the mechanical properties. Also, in this work we use to increase the hardness of the steel. We need a metal piece and try to find the mechanical properties using machine learning algorithm. This metal piece is required to cut into many pieces of different grades and then find out the microstructures of those different grades of metals. For this work we require a microscope by which we find out the images of the microstructures and then apply the machine learning algorithm.
Virtual Assistant for the Blind
Authors: Borkar Isshita , Shaikh Prof. Asma , Jadhav Snehal , Khandade Vaishnavi , Nagpure Bhakti
Published: December 2022

Abstract: In this world, certain people are visually impaired and they face a lot of problems while doing thereday-to-day work. Physical movement is one of the biggest challenges for the visually impaired. People with complete blindness or low vision often have a difficult time in self-navigating unfamiliar environments. Hencethis work is aiming for developing a device which will help them as their personal assistant. The goal of the present project is to model an object detector to detect objects for visually impaired people and other commercial purposes by recognizing the objects at a particular distance. The object recognition deep learning model utilizes the You Only Look Once(YOLO) algorithm and a voice announcement is synthesized using text-to-speech (TTS) to make it easier for the blind to get information about objects. This system proposes conglomeration of technologies like Image processing, Speech processing etc, so the problems faced by blind people can be reduced to certain extent. Object recognition methods in computer vision, Image processing, Text to Speech conversion can be embedded in a single object : SMART GLASSES (spectacles)