bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penyuluhan Metode Peer Group Support Terhadap Pengetahuan Penderita Diabetes Mellitus Tipe 2 Di Kelurahan Lepo-Lepo
Authors: Deni  , Angel Saputri Andi Muin  , Ririn Safitri  , Ermawati  , Ayu Anggraeni  , La Ode Liaumin Azim
Published: August 2024

Latar Belakang: DM Tipe 2 merupakan kondisi tubuh yang resisten terhadap insulin. Jika kondisi ini tidak terkontrol maka akan menyebabkan komplikasi kronis maupun akut salah satunya diabetic foot. Kondisi ini dapat dicegah dengan melakukan pengontrolan gula secara teratur melalui Peer Suport Group. Tujuan: Penelitian ini untuk mengetahui pengaruh penyuluhan metode peer group support terhadap pengetahuan penderita Diabetes Mellitus Tipe 2 di Kelurahan Lepo-Lepo. Metode: Jenis penelitian ini adalah pra eksperimen dengan metode the one group pretes-posttes design dimana merupakan salah satu metode penelitian pra eksperimen yang tidak ada kelompok pembanding (kontrol) tetapi sudah dilaksanakan observasi pertama (pre-test) yang memungkinkan menguji perubahan yang terjadi setelah adanya perlakuan (eksperiment). Penelitian ini dilakukan di Puskesmas Lepo-Lepo dengan sampel 27 orang menggunakan teknik purposive sampling. Data dianalisis menggunakan uji wilcoxon. Hasil: Penelitian menunjukkan bahwa rata-rata pengetahuan responden sebelum diberikan penyuluhan sebesar 6,00 dengan nilai standar deviasi sebesar 2,617 dan setelah diberikan penyuluhan rata-rata pengetahuan responden sebesar 12,59 dengan nilai standar deviasi sebesar 3,925 serta penyuluhan kesehatan metode pear group support berpengaruh terhadap pengetahuan responden tentang DM tipe 2 di Kelurahan Lepo-Lepo berdasarkan hasil uji statistik Wilcoxon diperoleh nilai p = 0,00 (<0,05). Kesimpulan: metode penyuluhan peer group support memiliki pengaruh terhadap Tingkat pengetahuan para penderita diabetes melitus di Kelurahan Lepo-Lepo
Hubungan Pola Makan Dan Aktivitas Fisik Dengan Kejadian Obesitas Pada Remaja di SMA Negeri 1 Abuki
Authors: Elsa Sari Saputri  , Samsudi
Published: August 2024

Latar Belakang: Prevalensi obesitas remaja pada usia 13–15 tahun di Indonesia sebesar 4,8%. Angka prevalensi obesitas tersebut tinggi dikarenakan oleh berbagai faktor, salah satunya adalah pola makan dan aktivitas fisik. Tujuan: Untuk mengetahui hubungan pola makan dan aktivitas fisik dengan kejadian obesitas pada remaja SMA Negeri 1 Abuki Tahun 2023 terhadap 41 responden sebagai sampel dalam penelitian ini. Metode: Jenis penelitian ini adalah metode kuantitatif dengan pendekatan Cros-Sectional. Populasi dalam penelitian ini yaitu seluruh siswa remaja berjumlah 82. Sampel yang digunakan dalam penelitian ini berjumlah 41 orang yang diambil menggunakan simple random sampling. Data yang diperoleh dari wawancara langsung dilapangan dengan menggunakan kuisioner serta pengukuran yang dilakukan, hasil pengukuran diolah dengan menggunakan SPSS 25 For Windows. Data kemudian dianalisis menggunakan analisis univariat dan analisis bivariate menggunakan uji statistic Chi Square. Hasil: Berdasarkan hasil uji statistik chi-square pada variabel pola makan didapatkan nilai p = 0,000, lebih kecil dari 0,05 (0,000 < 0,05). Sedangkan itu, hasil uji statistik chi-square pad avariabel aktivitas fisik didapatkan nilai p = 0,000, lebih kecil dari 0,05 (0,000 < 0,05). Simpulan: terdapat hubungan antara pola makan, dan aktivitas fisik terhadap kejadian obesitas pada siswa remaja SMA Negeri 1 Abuki Tahun 2023
Analisis dan Implementasi Toko Online From.Munch: Studi Kasus Pengembangan Platform E-Commerce
Authors: Ba Hadi Turki Salem , Darujati Cahyo
Published: August 2024

Era digital telah mengubah cara konsumen berbelanja, dengan semakin banyaknya pengguna internet yang beralih ke belanja online. Toko online atau platform e-commerce menjadi solusi bagi banyak bisnis untuk mencapai audiens yang lebih luas dan meningkatkan penjualan. Penelitian ini bertujuan untuk melakukan analisis dan implementasi toko online untuk From.Munch, sebuah perusahaan makanan dan minuman yang ingin mengembangkan platform e-commerce sebagai cara baru untuk menjangkau pelanggan. Studi kasus dilakukan untuk memahami kebutuhan dan persyaratan bisnis From.Munch dalam mengembangkan toko online. Tahap analisis melibatkan wawancara dengan pihak perusahaan, survei pelanggan, dan penelitian pasar untuk mengidentifikasi fitur dan fungsi penting yang harus dimiliki oleh platform e-commerce mereka. Setelah analisis selesai, dilakukan desain sistem untuk toko online From.Munch. Proses desain meliputi tata letak halaman, navigasi, fitur keranjang belanja, sistem pembayaran, manajemen produk, dan integrasi media sosial. Langkah selanjutnya adalah implementasi toko online berdasarkan desain yang telah disetujui. Platform e-commerce dibangun menggunakan teknologi dan bahasa pemrograman yang sesuai dengan kebutuhan From.Munch. Selain itu, uji coba dan pengujian dilakukan untuk memastikan bahwa toko online berfungsi dengan baik dan memenuhi standar kualitas.  Hasil dari penelitian ini adalah toko online From.Munch yang siap untuk digunakan oleh pelanggan. Platform e-commerce ini dapat meningkatkan aksesibilitas dan kenyamanan bagi pelanggan dalam berbelanja produk makanan dan minuman dari From.Munch. Selain itu, penggunaan toko online ini diharapkan dapat membantu perusahaan untuk meningkatkan penjualan, memperluas pangsa pasar, dan memperkuat kehadiran mereka di dunia digital. Penerapan toko online pada From.Munch menjadi contoh yang relevan bagi bisnis lain yang ingin memperluas bisnis mereka melalui platform e-commerce. Dalam konteks persaingan yang semakin ketat di dunia online, toko online dapat menjadi alat yang efektif untuk meningkatkan pertumbuhan bisnis dan memenuhi kebutuhan pelanggan yang semakin digital-oriented
Inovasi Sistem Pembayaran SPP Online untuk Efisiensi Administrasi di SMP Hangtuah 1 Surabaya
Authors: Hidayat M. Mahaputra
Published: August 2024

Inovasi Sistem Pembayaran SPP Online untuk Efisiensi Administrasi di SMP Hangtuah 1 Surabaya" merupakan sebuah penelitian yang bertujuan untuk memperkenalkan dan menganalisis sistem pembayaran SPP berbasis web yang diimplementasikan di SMP Hangtuah 1 Surabaya. Penelitian ini bertujuan untuk memahami bagaimana inovasi teknologi informasi dalam bentuk sistem pembayaran SPP online dapat meningkatkan efisiensi administrasi di sekolah. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan teknik pengumpulan data melalui wawancara, observasi, dan analisis dokumen terkait. Hasil penelitian menunjukkan bahwa implementasi sistem pembayaran SPP online di SMP Hangtuah 1 Surabaya telah memberikan kontribusi signifikan dalam meningkatkan efisiensi administrasi sekolah. Dengan adanya sistem ini, proses pengumpulan pembayaran SPP menjadi lebih mudah, cepat, dan terorganisir. Penelitian ini juga mengidentifikasi beberapa tantangan yang dihadapi dalam implementasi sistem pembayaran SPP online, seperti tingkat adopsi teknologi yang beragam di kalangan siswa dan orang tua, serta kebutuhan akan dukungan teknis yang kontinu. Meskipun demikian, kesimpulan penelitian ini menunjukkan bahwa inovasi ini memberikan manfaat yang signifikan dalam mengelola administrasi sekolah dengan lebih efisien dan efektif. Kesimpulannya, inovasi sistem pembayaran SPP online adalah langkah positif menuju modernisasi administrasi sekolah, yang berpotensi untuk meningkatkan transparansi, akuntabilitas, dan kualitas layanan pendidikan. Penelitian ini memberikan wawasan yang berharga bagi sekolah lain yang berencana untuk mengadopsi teknologi serupa dalam upaya meningkatkan efisiensi administrasi mereka.
Implementasi Media Pembelajaran Infografis Terhadap Hasil Belajar Kognitif Siswa Pada Mata Pelajaran Sejarah
Authors: Aoliah Nurlutfi , Usmaedi Usmaedi , Sampurna Iman
Published: August 2024

Mata pelajaran sejarah seringkali dihadapkan pada tantangan yang memengaruhi hasil belajar. Beberapa siswa merasa sulit untuk menemukan daya tarik dalam memahami kronologi peristiwa atau merasa bahwa materi sejarah tidak relevan dengan kehidupan sehari-hari mereka dan sangat membosankan. Selain itu, metode pengajaran konvensional yang kurang interaktif dapat menyebabkan dampak negatif terhadap pemahaman dan pencapaian hasil belajar kognitif siswa. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang melibatkan kerjasama antara peneliti dan guru kelas X SMA La-Tahzan. Peneliti terlibat dalam merancang, merencanakan, melakukan tindakan, observasi, refleksi, dan pelaporan penelitian. Tujuan utama penelitian ini adalah untuk meningkatkan proses pembelajaran agar lebih efektif dan efisien bagi siswa. Data penelitian menunjukkan bahwa rata-rata nilai siswa meningkat pada siklus I dari 49,9 menjadi 60,33 dan pada siklus II dari 64,36 menjadi 84,8. Selain itu, tingkat ketuntasan belajar siswa juga mengalami peningkatan dari 6,6% pada siklus I menjadi 23,3%, dan pada pembelajaran akhir siklus II hasil siswa dari 43,3% menjadi 99,6%. Penggunaan media infografis dalam pembelajaran sejarah terbukti efektif dalam membantu siswa memahami materi lebih baik, meningkatkan performa akademik mereka secara keseluruhan, serta meningkatkan keterlibatan mereka dalam proses belajar.
INVESTIGAÇÃO DE MANIFESTAÇÕES PATOLÓGICAS NOS SISTEMAS DE REVESTIMENTOS CERÂMICOS DE FACHADAS EM UMA EDIFICAÇÃO RESIDENCIAL LOCALIZADA EM VITÓRIA/ES
Authors: Roldi Núbia , Nunes Kaio , de Oliveira Luiz Daniel
Published: August 2024

Os sistemas de revestimentos cerâmicos de fachadas das edificações estão sujeitas aos desgastes naturais ocasionados pela exposição das características físico-químicas dos diversos materiais componentes e  principalmente pela agressão do meio ambiente, de modo que a presença de erros nas etapas de projeto e de sua execução, a ausência de manutenções, as deficiências nas especificações dos materiais empregados nos revestimentos e os erros no acompanhamento dos procedimentos técnicos vão desencadear o surgimento de manifestações patológicas nessas estruturas. Diante desse cenário, o objetivo dessa pesquisa é investigar as manifestações patológicas nos sistemas de revestimentos cerâmicos de fachadas em uma edificação residencial multifamiliar, localizado no bairro Santa Lúcia,  município de Vitória/ES, no qual visa identificar os diagnósticos e prognósticos, com base nas causas e nos mecanismos das ocorrências das manifestações patológicas mais decorrentes nessas estruturas, para efetuar o seu tratamento e sanar os danos nos revestimentos cerâmicos em fachadas oriundos da presença das falhas e anomalias que afetam a durabilidade e o desempenho da edificação. Dessa forma, de acordo com vistoria “in loco”, foi identificada, por meio da avaliação sistêmica, a presença de destacamento de placas cerâmicas nos sistemas de revestimentos cerâmicos de fachadas da edificação. Portanto, o presente estudo exploratório e descritivo, baseado em uma pesquisa bibliográfica e estudo de caso, sendo de caráter qualitativo e de natureza aplicada tencionou auxiliar a importância na execução de manutenções e reparos dentro dos prazos e expor as técnicas pertinentes para o tratamento das falhas e anomalias nas fachadas da edificação, a fim de contribuir para a segurança dos usuários e favorecer a estética e a durabilidade de suas estruturas, ao longo da sua vida útil.
Penerapan Pendekatan Pembelajaran Koperatif Tipe Make A Macth Untuk Meningkatkan Prestasi Belajar Siswa Mata Pelajaran IPS Kelas III SDN 2 Rensing Tahun Pelajaran 2021/2022
Authors: Rahman Zikri
Published: August 2024

Penelitian ini dilatar belakangi oleh kondisi yang dihadapi dalam proses pembelajaran IPS, yang disebabkan oleh cara mengajar guru yang masih menggunakan metode bersifat monoton dan pada saat pembelajaran berlangsung peserta didik terlihat kurang tertarik dengan pembelajaran yang disampaikan oleh pendidik. Fokus masalahnya adalah bagaimana meningkatkan hasil belahar siswa degan penerapan model pembelajaran kooperatif tipe Make a Match pada mata pelajaran IPS materi Jual Beli pada kelas III SD Negeri 2 Rensing Kec. Sakra Barat tahun pelajaran 2021/2022. Tujuannya adalah mendeskripsikan penerapan model pembelajaran kooperatif tipe make a match dan hasil belajar IPS pada materi jual beli kelas III SD Negeri 2 Rensing Kec. Sakra Barat Tahun Pelajaran 2021/2022.
Penelitian ini menggunakan Penelitian Tindakan Kelas (Classroom Action Research) sebanyak dua siklus. Setiap siklus terdiri dari empat tahap yaitu perencanaan, pelaksanaan, pengamatan dan refleksi. Obyek penelitian ini adalah siswa kelas III SD Negeri 2 Rensing Kec. Sakra Barat. Teknik yang digunakan dalam mengumpulkan data antara lain tes, observasi, dan dokumentasi. Analisis data yang digunakan mencakup reduksi data, penyajian data, dan penarikan kesimpulan. Indikator keberhasilan dalam penelitian ini apabila penguasaan materi peserta didik mencapai 75% dari tujuan yang seharusnya dicapai, dengan nilai KKM 70.
Hasil penelitian menunjukkan bahwa pembelajaran IPS dengan menggunakan tipe Make A Match dapat meningkatkan hasil belajar siswa pada materi Jual Beli. Hal ini ditunjukkan dengan hasil belajar peserta didik Pada siklus I nilai rata-rata siswa 71,76 dengan ketuntasan belajar klasikal siswa sebesar  64% dan rata-rata skor aktivitas siswa yaitu 11,61 dengan kategori cukup aktif. Pada siklus II dengan nilai rata-rata yaitu 77,29 dengan ketuntasan belajar klasikal siswa sebesar 88% dan rata-rata skor aktivitas belajar siswa mencapai 14,76 dengan kategori aktif. Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunakan pendekatan pembelajaran kooperatif tipe make a macth dapat meningkatkan prestasi belajar IPS siswa kelas III SDN 2 Rensing.
Perspektif Hamka Tentang Urgensi Pendidikan Tasawuf Dalam Kehidupan Masyarakat Modern
Authors: Aldin Aldin
Published: August 2024

Penelitian ini dilatarbelakangi oleh perhatian penulis terkait beragamnya nestapa yang dialami masyarakat modern, di mana masyarakat dewasa ini telah mengalami kehampaan spiritual yang diakbitkan oleh pendewaan yang berlebihan terhadap ilmu pengetahuan dan teknologi. Kondisi tersebut semakin diperparah karena adanya ekses seperti sekularisme, liberalisme, rasionalisme, dan materialisme yang hanya menekankan hidup kebendaan semata dan menegasikan aspek spiritual dalam diri manusia. Sehingga kemajuan manusia dewasa ini bukan dalam budi pekerti, melainkan hanyalah dalam dunia amuk dan merusak binasakan. Maka penulis menilai pendidikan tasawuf modern Hamka penting untuk dijadikan rujukan dalam kehidupan yang penuh dilematis dan kompeks ini.
Jenis penelitian ini menggunakan penelitian library research atau penelitian kepustakaan. Metode pengumpulan data yang digunakan adalah dokumentasi, sedangkan metode analisis data yang digunakan adalah analisis deskriptif, analisis interpretatif, dan analisis kesinambungan historis.
Hasil penelitian ini menunjukan bahwa (1) konsep pemikiran tasawuf modern Hamka terdiri dari enam konsep yaitu, pemaknaan pendidikan tasawuf, tujuan pendidikan tasawuf, fungsi pendidikan tasawuf, metode pendidikan tasawuf, objek kajian pendidikan tasawuf, sumber pendidikan tasawuf. (2) urgensi pendidikan tasawuf modern Hamka dalam kehidupan masyarakat kontemporer yaitu, pendidikan tasawuf modern Hamka dapat membentuk masyarakat modern yang berbudi luhur, pendidikan tasawuf modern Hamka secara seimbang memberikan kesejukan batin dan disiplin syari’ah sekaligus, pendidikan tasawuf modern Hamka dapat membantu masyarakat modern dalam mencapai kebahagiaan hidup.
Antara Label Halal Dengan Keputusan PembelianDalam Perspektif Hukum Ekonomi Syariah
Authors: Andi Fariana  , Ahmad Lutfi Rijalul Fikri
Published: August 2024

This study aims to examine the influence of halal labeling on consumer purchasing decisions in Indonesia, considering the rapid innovation in food products and the importance of information related to product halal status. Employing a qualitative descriptive method, this research explores relevant journals, compares findings, and analyzes pertinent regulations and fatwas. The results indicate that halal labels on products significantly influence purchasing decisions for both food and non-food products, such as cosmetics, with consumers feeling more secure and confident about the products' halal status. This study highlights the crucial role of government regulations and certification bodies like MUI and BPJPH in ensuring product halal compliance, providing guidance for producers to attract consumer interest through clear halal labelling
Abordagem Multidisciplinar no Tratamento da Icterícia Neonatal
Authors: Nascimento da Silveira Gomes Rebecca , De Fatima da Conceição Veríssimo Lopes Juliana , Salmem Rodrigues Maria Eduarda , Mendes dos Santos Pâmela , Alexandre da Silva Dantas Luan , Rosa Vieira Pacheco Hellen , Pinto de Araújo Andresa , Oliveira Véras Raul Felipe , De Oliveira Carlos Pâmella , Pereira da Silva Anderson Matheus , Sousa Da Silva Clara Beatriz , Diógenes Magalhães Leyliane
Published: August 2024

A icterícia neonatal constitui uma condição frequente em neonatos, sendo uma das principais causas de hospitalização de recém-nascidos (RN) nas primeiras semanas de vida. Embora usualmente benigna, pode evoluir para complicações graves, como a encefalopatia bilirrubínica, se não tratada adequadamente. Desse modo, o objetivo deste trabalho é investigar a eficácia da abordagem multidisciplinar no tratamento da icterícia neonatal ocasionada pelo aumento da bilirrubina indireta, bem como as principais intervenções utilizadas e seus impactos nos desfechos clínicos dos recém-nascidos. Trata-se de uma revisão integrativa elaborada a partir de uma pesquisa nas bases de dados da EBSCOHost, PubMed e Google Scholar, utilizando a seguinte estratégia de busca: ((Icterícia Neonatal OR Jaundice, Neonatal) OR (Hiperbilirrubinemia Neonatal OR Hyperbilirubinemia, Neonatal)) AND (Equipe de Assistência Multidisciplinar OR Multidisciplinary Health Team). Os resultados revelaram a importância da sinergia entre as áreas de saúde, aliada ao uso de tecnologias avançadas para monitorização e controle do ambiente, bem como da implementação de protocolos de cuidados padronizados e de  avaliações criteriosas como aspectos-chave para um melhor prognóstico e prevenção de complicações. Portanto, evidenciou-se que a implementação de uma abordagem integrada e colaborativa constitui uma estratégia fundamental para a melhora dos resultados no manejo dessa condição em neonatos.
Impactos e intervenções do transtorno de estresse pós-traumático: um olhar clínico e terapêutico
Authors: Santos Ananda Saunders Fernandes , Leonardo Tonelotto Pizetta  , Giovanna Aparecida da Silveira  , Beatriz Pereira Dutra  , Gabrielly Jack Frizon  , Jusciellyson da Silva Nava  , Guilherme Aleff Matos de Morais  , Rodrigo Barbosa Guerra  , André Felipe Nunes Ost  , Shayene Bion da Silva  , Jonathan França Vargas  , Elane Frota Aragão  , Aryane Sá Viana  , Wellen Bárbara Braga Cavalcanti  , Beatryz Rodrigues Alves Batista  , Elena Scardueli  , Alessandra Eliana Gauze  , Gustavo Almeida Granja  , Tainá Borges Ferrari  , Nicolas Fraga Pinheiro  , Anderson Peixoto da Silva  , Claudio Eduardo Luiz Granja Junior
Published: August 2024

O Transtorno de Estresse Pós-Traumático (TEPT) é um distúrbio de saúde mental que surge após a exposição a eventos traumáticos, como violência, acidentes graves ou desastres naturais. Caracteriza-se por sintomas como revivências intrusivas, esquiva, alterações negativas no pensamento e humor, e hiperatividade. Esses sintomas podem persistir por meses ou anos, prejudicando significativamente a vida diária do indivíduo. O TEPT afeta pessoas de todas as idades e origens, e seu impacto pode ser devastador sem o diagnóstico e tratamento adequados. A compreensão e abordagem do TEPT são fundamentais para a recuperação e melhoria da qualidade de vida dos afetados. Essa revisão de literatura foi realizada por meio de publicações científicas encontradas nos seguintes bancos de dados: Biblioteca Virtual de Saúde (BVS), Public Medline (PubMed), Portal de Periódicos CAPES e Scientific Electronic Library Online (SciELO), sem restrição de período. Foram também consultados os sites oficiais do Ministério da Saúde e a literatura cinzenta. O Transtorno de Estresse Pós-Traumático (TEPT) é uma condição complexa que pode ter efeitos profundos e duradouros na vida dos indivíduos afetados. Compreender seus sintomas, causas e métodos de tratamento é essencial para o manejo eficaz do transtorno. Embora o TEPT possa ser debilitante, abordagens terapêuticas como a Terapia Cognitivo-Comportamental e a EMDR, além de intervenções medicamentosas, têm mostrado resultados promissores na recuperação dos pacientes. O apoio contínuo de profissionais e redes de suporte é crucial para ajudar os indivíduos a superar os efeitos do trauma e retomar uma vida plena e funcional.
Síndrome de Alport: manejo terapêutico atualizado
Authors: Hanna Barreto Dias  , Vinicius Antonio Magalhães de Freitas Dutra  , Leonardo Naoki Maciel Miki  , Wallace Machado de Araújo  , Eliseu Ribeiro Caldas  , Carmen Rosauro de Mello  , Raysa Rangel Rodrigues  , Gustavo Smit Schlosser  , Anna Isabel Rocha de Oliveira  , Maria Letícia Cardoso Costa de Barros  , Cleto Martins dos Santos Neto  , Cendi da Cruz Oliveira de Freitas  , Laura Silva Welter  , Murillo Barbosa Loubet  , Livia Catarina Lopes Vianna Couto  , Guilherme Ribeiro Xavier  , Italo Santiago dos Santos
Published: August 2024

INTRODUÇÃO: A Síndrome de Alport (SA) é uma doença hereditária renal causada por mutações nos genes COL4A3, COL4A4 e COL4A5. Clinicamente, a doença pode se manifestar de diversas maneiras, tendo potencial de causar hematúria, glomeruloesclerose e proteinúria, podendo evoluir para doença renal em estágio terminal. Nesse contexto, esse estudo tem como objetivo analisar as terapêuticas atuais disponíveis para tratamento da Síndrome de Alport, e verificar quais novas terapias estão em desenvolvimento. METODOLOGIA: Trata-se de uma revisão integrativa da literatura da base de dados PUBMED. Foram utilizados os descritores: “ALPORT SYNDROME AND THERAPIES’’. Foram selecionados artigos científicos do período de 2019. RESULTADOS: Atualmente, o tratamento de SA é baseado no uso de inibidor da enzima conversora da angiotensina (IECA), devido ao efeito de diminuírem a proteinúria e bem como o processo de fibrose renal, de modo que adie o processo de fibrose. Foi relatado o efeito nefroprotetor e de redução da albuminúria do cotransportador de sódio-glicose-2, mais conhecido como empagliflozina, a partir de vasodilatação da arteríola aferente. Medicamentos que causam diminuição da inflamação renal e fibrose, como a bardoxolona e metformina, levam a diminuição da proteinúria e da taxa de filtração glomerular estimada estável. Além disso, estão em desenvolvimento as terapias de substituição de genes. CONCLUSÃO: O manejo atual de pacientes com Síndrome de Alport é o uso de IECA e medicamentos que causam diminuição da inflamação renal e fibrose. Entretanto, os recentes estudos de terapias genéticas representam um possível avanço no tratamento da doença.
Hidrocefalia pós-traumática e fatores associados
Authors: Murillo Barbosa Loubet  , Anna Isabel Rocha de Oliveira  , Carmen Rosauro de Mello  , Cendi da Cruz Oliveira de Freitas  , Eliseu Ribeiro Caldas  , Gustavo Smit Schlosser  , Jefferson Bezerra Gomes  , Leonardo Naoki Maciel Miki  , Livia Catarina Lopes Vianna Couto  , Maria Letícia Cardoso Costa de Barros  , Mateus Luiz de Godoi  , Raysa Rangel Rodrigues  , Vinicius Antonio Magalhães de Freitas Dutra  , Wallace Machado de Araújo  , Guilherme Ribeiro Xavier  , Italo Santiago dos Santos
Published: August 2024

O trauma cranioencefálico (TCE) vem sendo um dos principais responsáveis de mortalidade no mundo. E como consequência, uma de suas complicações é a hidrocefalia pós-trauma (HPT), que consiste no acúmulo de líquido cefalorraquidiano nos ventrículos, geralmente por uma obstrução do fluxo. Os sintomas são diversos, e por isso devem ser investigados com cautela. Dentre as formas já utilizadas para tratamento temos a craniectomia descompressiva, que atualmente vem sendo bastante criticada e cada vez mais estudos mostram sua relação com o desenvolvimento da HPT. OBJETIVO: Avaliar as causas de hidrocefalia pós-traumática, bem como entender os fatores associados. METODOLOGIA: Trata-se de uma revisão integrativa na base de dados PUBMED utilizando os descritores: “POST TRAUMATIC AND HYDROCEPHALUS’’ para artigos publicados entre 2019 e 2024. RESULTADOS: As principais causam de TCE foram acidentes automobilísticos e quedas. Pacientes com HPT eram mais propensos a apresentar a escala de Glasgow significativamente baixo, diabetes, hematoma intracerebral e internação hospitalar prolongada. Para o tratamento, pacientes submetidos a craniotomia apresentaram maiores chances de desenvolver HPT. Na faixa pediátrica, a maior incidência foi em pacientes de 0 a 5 anos (0,17%) e as principais manifestações clínicas foram: respiratórias, cardíacas, renais e urinárias, hematomas, tromboembólicas, septicemia e outras complicações neurológicas. CONCLUSÃO: A HPT apresenta forte relação com episódios traumáticos, principalmente quedas. Dentre os procedimentos cirúrgicos, a craniectomia descompressiva foi a que mais levou ao desenvolvimento de HPT. Diversos problemas cardiorrespiratórios e neurológicos foram relatados devido a HPT.
Trends in Flipped Classroom of Higher Education: Bibliometric Analysis (2012–2022)
Authors: Rakhmalinda Fika
Published: August 2024

The “flipped classroom” learning model in higher education that requires preparation of technological and pedagogical knowledge in Higher Education. This study was viewed bibliometrically from 2012-2022 using data collection techniques microsoft excel and Vos Viewer. The purpose of this study is to explain the flipped classroom trend in high education. This document is taken from the collection of Scopus articles. The keyword used was “flipped classroom” with a total of 2821 documents, but 2054 were selected for bibliometric analysis with certain criteria. The results showed that the United States of America was the document publication with the highest number of citations. This study presents data from Scopus as many as 2054 published data. In 2015 the article belongs to O’Flaherty J., Phillips achieved the most citations, namely 1011 other authors. While in 2017-2021 the number of citations is as much as19902 and is expected to continue to increase in 2022 (currently n=121 Scopus documents, citations of 289 articles). Another finding is that the trend of flipped classrooms continues to increase in Higher Education to hone 21st century skills.
Identify Students’ Misconceptions on Electrolysis using Two-Tier Diagnostic Test
Authors: Hutahaean Esrida , Pardiana Pardiana , Hadiyati Yanti
Published: August 2024

In the literature, lack of conceptual understanding makes it difficult for students to relate chemistry to their learning experience, leading to misconceptions. Misconceptions are defined as phenomena where students have concepts that differ from scientific concepts. Misconceptions will affect how students construct scientific knowledge in the next learning material. Therefore, the study of this misconception is an important concern in the field of education. The purpose of this study was to identify students’ misconceptions on electrolysis material. The instrument used in the study was a two-tier diagnostic test consisting of 10 questions at the first level and supporting reasons at the second level. The questions contained in this instrument are taken from previous research. This study used a qualitative descriptive approach involving 55 students from class XII Analytical Chemistry in one of the vocational high schools in Cilegon City. The results showed that out of a total of 55 students, there were students who understood the concept as much as 34%, students who experienced misconceptions as much as 30.73%, students who understood partially as much as 9.82% and students who did not understand the concept as much as 25.45%.
Trends of Design Thinking Research in STEM Education: Bibliometric Analysis
Authors: Ghufrooni Rifqi
Published: August 2024

Research on design thinking in education is increasing from year to year. design thinking offers creative freedom to teach, serving as a guide to enhancing the STEM experience for students. The purpose of this study is to provide an up-to-date map that explains and systematizes a collection of information from the Scopus database relating to design thinking research in STEM education. The keywords used are “design thinking” AND “STEM Education”. A total of 812 documents were identified from various types of documents and years. All data were used in bibliometric analysis. The findings show that design thinking research in STEM education has increased every year with the use of English as the most widely used language. The most published type of document is the Conference Paper. The United States of America is the most productive country with the highest number of publications and citations. The most published author is Lee. CS while Ramani K got the most citations. The most influential journal is Design Studies while the most productive source is ASEE Annual Conference and Exposition. While articles written Stempfle (2002) recorded as the most cited articles. The most used author keyword in articles is design thinking.
Bibliometric Analysis of Mobile Learning Research Trends Over the Last Decade
Authors: Handayani Erna
Published: August 2024

The use of mobile devices in learning is increasing, allowing students to access learning resources. In the ever-growing digital era, mobile learning not only offers innovative learning alternatives but also shapes the future of education. This study provides a comprehensive bibliometric analysis of 8352 articles on mobile learning in higher education from 2002 to 2023. With the help of VOSViewer, the researcher can explore complex relationships between scientific information, gain deep insights into specific subject areas, and make decisions supported by powerful bibliometric analysis. Key findings reveal a peak in 2019 with 673 publications, and the most cited work is “Current Status, Opportunities And Challenges Of Augmented Reality In Education” by Wu et al. (2013) with 1285 citations. Prolific authors include Hwang, Huang, Ogata, and Looi. Productive sources are ACM International Conference Proceedings Series and journals like International Journal Of Mobile Learning And Organization. Institutions like National Taiwan University and countries like ChinaUnited States, and Taiwan lead in productivity. Top keywords include “mobile learning,” “e-learning,” and “students,” offering insights for future research planning
Research Trends of Computational Thinking: A Bibliometric Review Over Three Decades
Authors: Abadi Sela Marselyana
Published: August 2024

Currently, computational thinking is considered one of the future abilities that students must have. However, existing research has not offered comprehensive findings and explorations of computational thinking. This research presents bibliometric analysis research to investigate the development of research on computational thinking abilities at all levels of education. Specifically, the main aim of this research is to analyze trends in computational thinking research using bibliometric mapping based on variables: publications, citations, keywords, journals, authors, and countries. The initial search produced 5188 documents, which were then filtered into 1599 articles according to the inclusion and exclusion criteria. The first article recorded was from 1987 and the number of articles published increased in 2014-2022. This shows that the research trend in computational thinking has become a quite popular research topic in line with the awareness of the importance of computational thinking skills as one of the abilities that must be needed by the current generation. In relation to keywords related to computational thinking, discussion of computational thinking abilities is no longer limited to computer science or programming, but has spread to education, whether learning, assessment, or other supporting abilities. In addition, it is also identified the most productive journals in producing research on this topic, along with institutions and countries that have made major contributions to the related research. As the most productive country, the United States leads the list, followed by China and Türkiye. Overall, these results provide a broad picture of understanding regarding the development of computational thinking abilities that have been connected to various fields. Therefore, in the field of education, it is appropriate for policy holders to consider computational thinking skills to be integrated into the current curriculum.
English summaries
Authors: Anbert Lærke Cecilie
Published: August 2024

English summaries
ANALYSIS OF THE INFLUENCE OF WORKING TIME FLEXIBILITY AND LABOUR LAW STATUS FLEXIBILITY ON THE REDUCTION OF THE UNEMPLOYMENT RATE
Authors: Blažević Dević Ivona
Published: August 2024

With the aim of analyzing the impact of employment in the observed flexible forms of work on the unemployment rate in Austria, Croatia, Italy, Hungary and Slovenia, the author systematically investigated and analyzed the impact of working time flexibility and labour law status flexibility on the unemployment rate. The aim of this paper is to investigate the connection between the unemployment rate and the proportion of people surveyed in the sample who work in the following flexible forms of work: work in shifts, evening work, night work, work on Saturdays, work on Sundays and work from home. The research in the paper was conducted on the EU LFS official data set obtained on the basis of the RPP 35/2020-LFS project approved by the European Commission and Eurostat. The author analyzed a sample of 447,031 respondents in the period from 2008 to 2018. In the research part of the work, a statistically significant model of the linear association of the criterion variable of the unemployment rate with the predictor variable SENSSH and a statistically significant model of the nonlinear association of the criterion variable of the unemployment rate with the predictor variable SENSSH will be generated for each observed EU country. Based on an extensive analysis of data from selected EU member states, results were obtained that indicate an evident reduction in the unemployment rate in 80% of the observed countries through the introduction of flexible forms of employment.
THE INFLUENCE OF THE AMOUNT OF MATERIAL COMPENSATION PER EMPLOYEE ON THE COMPANY’S BUSINESS
Authors: Katolik Kovačević Andreja , Požega Željko , Vučemilović Vesna
Published: August 2024

In order to evaluate the impact of the amount of material compensation per employee on the performance of the company, the authors systematically analysed amount of material compensation per employee, total income, total expenses, net profit margin and return on equity in small, medium and large companies in the five observed counties of the Republic of Croatia. The aim of the paper is to analyse the connection between the amount of material compensation of employees and the performance of the company. The research in the paper was conducted based on data provided by the Financial Agency, a leading Croatian company in the field of providing financial and electronic services. The research was conducted on a sample of 3,914 small, medium and large companies. In the research part of the paper, Spearman’s correlation coefficient which is a non-parametric equivalent of Pearson’s correlation coefficient (product of rank correlation), was used to assess the relationship between the variables of average monthly net wage and salary per employee, total income, total expenses, net profit margin, return on equity. The results indicate that there are significant differences between the size of the company and the observed parameters (average monthly net wages and salaries per employee, total income, total expenses, net profit margin, and return on equity). Based on an extensive analysis of data, obtained results indicate that the given correlation matrix of the connection between the average monthly net wage and salary per employee with the observed parameters for all years shows that all parameters are statistically significantly correlated. This paper provides an insight into the importance of human resources and their proper management on the company business, regardless of their size. Statistical analysis of research data was performed by statistical software MedCalc® Statistical Software and SPSS Statistics for Windows.
TAXATION OF DIGITAL SERVICES
Authors: Dražić Lutilsky Ivana , Broz Tominac Sanja , Dragija Kostić Martina
Published: August 2024

Digital services are changing our society and economy, bringing new challenges and problems for tax policy through development of digital economy. Digital companies have new business models, often without a physical presence in different countries, and at the same time they provide services to users whose contribution creates value for these companies that states cannot tax under current rules as traditional services. Also, it is often hard to determine the location of a customer which is important for taxation. There are some important factors influencing taxation of digital service such as significant economic presence from companies and creation of big data by users of different countries. Some countries have introduced their taxes on digital services independently, which means that there is no consensus on the taxation of digital services at the international level. The aim of this paper is to highlight the tax treatment of digital services in the European Union and, consequently, in Croatia. Also, authors will analyze the legal solutions for the taxation of digital services in France, the United Kingdom and the Republic of India, and make proposals for the introduction of taxes on digital services in Croatia.
THE IMPACT OF DIGITAL TECHNOLOGIES AND TOOLS ON BUSINESS COMMUNICATION IN CONTEMPORARY BUSINESS ENVIRONMENT
Authors: Lukić Nikolić Jelena
Published: August 2024

This paper examines the impact of digital technologies and tools on business communication in the contemporary business environment through the prism of new communication channels. Every technological breakthrough throughout history has altered the way people communicate, beginning with the discovery of the printing press, telegraph, radio, and television. In the fifth industrial revolution and contemporary environment, business communication becomes increasingly focused on current digital technologies and tools. Traditional communication, which was inherently slow, is being phased out in favor of interactive and quick communication. Communication through modern digital technologies and tools has many benefits, but it also has some drawbacks, including the possibility of misunderstandings and conflict. This paper discusses the digital age’s key communication channels, including smart mobile phones, short messages (sms), multimedia messages (mms), voice mail, Viber, WhatsApp, iMessage, Skype, Google Hangouts, Slack, teleconferences, video conferences, e-mail, intranet, organizational social and professional networks, and various business communication applications. Besides from their essential characteristics and advantages, this paper highlights key limitations that should be considered in order to eliminate or lessen misunderstandings and conflict situations.
AGE-RELATED DIFFERENCES IN INSTAGRAM USAGE AND LUXURY BRAND PERCEPTION: A STUDY IN CROATIA
Authors: Pirić Valentina , Koričan Lajtman Mirna , Martinović Maja
Published: August 2024

The study investigates Instagram usage frequency, reasons among various age groups, and potential age-related differences in customers’ perceptions of luxury brands and purchase intentions. Additionally, literature on Instagram’s influence on customer perception, brand image, luxury brand perception, and generational trends in digital consumer behavior was analyzed. Conducted in Croatia, the study utilized a non-random convenience sample of 192 respondents. The questionnaire comprised 32 questions split into two sections: the first gathered demographic data to profile the sample, while the second assessed social media use and participants’ perceptions of the influence of Instagram marketing activities on brand image and buying intentions. Descriptive and multivariate analyses were conducted using IBM SPSS software version 22 to evaluate the hypotheses. The study found a higher participation of women than men, with an average age of 28, which aligns with previous research in the field. Significant disparities in media utilization were observed between younger (average age 22.34) and older (average age 34.75) participants. Instagram is primarily used by women and younger age groups, with 95% of younger participants accessing it daily. The study confirmed that younger users are more interested in friends’ activities, sharing their own activities, and viewing appealing images, while older users follow brands/celebrities and seek personal content, which supports the hypothesis that reasons for using Instagram vary by age. Younger participants believe Instagram significantly influences luxury brand image and their buying intentions. Both age groups reported that a positive brand image influences purchase intent similarly, partially supporting the hypothesis that age affects luxury brand perception and buying intention on Instagram. The study highlights the importance of age diversity in creating effective marketing strategies on Instagram, influencing consumer behavior and purchase decisions, and enhancing understanding of Instagram’s influence on luxury brand perceptions and purchasing behavior across various generations in Croatia.
Biocalcification in porcelaneous foraminifera
Authors: Dubicka Zofia , Tyszka Jarosław , Pałczyńska Agnieszka , Höhne Michelle , Bijma Jelle , Jense Max , Klerks Nienke , Bickmeyer Ulf
Published: August 2024

Living organisms control the formation of mineral skeletons and other structures through biomineralization. Major phylogenetic groups usually consistently follow a single biomineralization pathway. Foraminifera, which are very efficient marine calcifiers, making a substantial contribution to global carbonate production and global carbon sequestration, are regarded as an exception. This phylum has been commonly thought to follow two contrasting models of either in situ ‘mineralization of extracellular matrix’ attributed to hyaline rotaliid shells, or ‘mineralization within intracellular vesicles’ attributed to porcelaneous miliolid shells. Our previous results on rotaliids along with those on miliolids in this paper question such a wide divergence of biomineralization pathways within the same phylum of Foraminifera. We have found under a high-resolution scanning electron microscopy (SEM) that precipitation of high-Mg calcitic mesocrystals in porcelaneous shells takes place in situ and form a dense, chaotic meshwork of needle-like crystallites. We have not observed calcified needles that already precipitated in the transported vesicles, what challenges the previous model of miliolid mineralization. Hence, Foraminifera probably utilize less divergent calcification pathways, following the recently discovered biomineralization principles. Mesocrystalline chamber walls in both models are therefore most likely created by intravesicular accumulation of pre-formed liquid amorphous mineral phase deposited and crystallized within the extracellular organic matrix enclosed in a biologically controlled privileged space by active pseudopodial structures. Both calcification pathways evolved independently in the Paleozoic and are well conserved in two clades that represent different chamber formation modes.
Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality
Authors: He Qiong , Zhao Miao-Miao , Li Ming-Jia , Li Xiao-Ya , Jin Jian-Min , Feng Ying-Mei , Zhang Li , Huang Wei Jin , Yang Fangyuan , Yang Jin-Kui
Published: August 2024

Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and retinopathy. Our previous research identified CTSL as a pivotal protease promoting SARS-CoV-2 infection. Here, we demonstrate elevated blood CTSL levels in individuals with diabetes, facilitating SARS-CoV-2 infection. Chronic hyperglycemia correlates positively with CTSL concentration and activity in diabetic patients, while acute hyperglycemia augments CTSL activity in healthy individuals. In vitro studies reveal high glucose, but not insulin, promotes SARS-CoV-2 infection in wild-type cells, with CTSL knockout cells displaying reduced susceptibility. Utilizing lung tissue samples from diabetic and non-diabetic patients, alongside Leprdb/dbmice and Leprdb/+mice, we illustrate increased CTSL activity in both humans and mice under diabetic conditions. Mechanistically, high glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum (ER) to the lysosome via the ER-Golgi-lysosome axis. Our findings underscore the pivotal role of hyperglycemia-induced CTSL maturation in diabetic comorbidities and complications.
A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Authors: Reveyaz Noémie , Schneeweiß Undine , Heise Olivia , Gerhardt Ben , Gui Andreea M , Kaufmann Lena V , Alfken Jette , Reichmann Jakob , Salditt Tim , Hildebrandt Thomas , Brecht Michael
Published: August 2024

Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. These ventral brainstem protrusions have previously been referred to as inferior olive, but a delineation of the olivo-cerebellar tract reveals these (trigeminal) nuclei are not connected to the cerebellum via climbing fibers. In contrast, the olivo-cerebellar tract connects to a large dorsolateral nucleus with a serrated cellular architecture, the putative elephant inferior olive. Dense vascularization and intense cytochrome-oxidase reactivity distinguish several elongated trigeminal putative trunk modules, which repeat in the anterior-posterior direction. We focus on the most anterior and largest of these units, the putative nucleus principalis trunk module. Module neuron density is low and non-neural cells outnumber neurons by ∼108:1. Dendritic trees are elongated along the axis of axon bundles (myelin stripes) transversing the trunk module. Synchrotron X-ray-phase-contrast tomography suggests myelin-stripe-axons transverse the trunk module. We show a remarkable correspondence of trunk module myelin stripes and trunk folds. Myelin stripes show little relation to trigeminal neurons and stripe-axons appear to often go nowhere; we suggest that myelin stripes might serve to separate trunk-fold domains rather than to connect neurons. Myelin-stripes-to-folds mapping allowed to determine neural magnification factors, which changed from 1000:1 proximally to 5:1 in the trunk finger. Asian elephants have fewer (∼640,000) trunk-module neurons than Africans (∼740,000) and show enlarged representations of trunk parts involved in object wrapping. The elephant trigeminal trunk module is exquisitely organized into trunk-fold-related units.