bluuebunny/crossref_metadata_2025 huggingface dataset:
The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding
Authors: Mattila S. Orvokki , Tuusa Jussi T. , Petäjä-Repo Ulla E.
Published: February 2016

The G-protein-coupled receptor 37 ( GPR37) has been implicated in the juvenile form of Parkinson's disease, in dopamine signalling and in the survival of dopaminergic cells in animal models. The structure and function of the receptor, however, have remained enigmatic. Here, we demonstrate that although GPR37 matures and is exported from the endoplasmic reticulum in a normal manner upon heterologous expression in HEK293 and SH-SY5Y cells, its long extracellular N-terminus is subject to metalloproteinase-mediated limited proteolysis between E167 and Q168. The proteolytic processing is a rapid and efficient process that occurs constitutively. Moreover, the GPR37 ectodomain is released from cells by shedding, a phenomenon rarely described for GPCRs. Immunofluorescence microscopy further established that although full-length receptors are present in the secretory pathway until the trans-Golgi network, GPR37 is expressed at the cell surface predominantly in the N-terminally truncated form. This notion was verified by flow cytometry and cell surface biotinylation assays. These new findings on the GPR37 N-terminal limited proteolysis may help us to understand the role of this GPCR in the pathophysiology of Parkinson's disease and in neuronal function in general.
CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons
Authors: Eckenstaler Robert , Lessmann Volkmar , Brigadski Tanja
Published: February 2016

The secretory protein brain-derived neurotrophic factor (BDNF) is assumed to be a key factor for the induction of synaptic plasticity processes in neurons. However, the molecular mechanisms for activity-dependent release of the protein largely remain elusive. Here, we demonstrate the relevance of the priming factor CAPS1 (also known as CADPS) for the maturation and exocytosis of BDNF-containing secretory granules, as well as for neurotransmitter release from synaptic vesicles. Using live-cell imaging and RNA silencing methods, we show that CAPS1 has a previously unrecognized function in regulating the intragranular pH of BDNF-containing secretory granules. Furthermore, our results demonstrate that acute single-cell knockdown of CAPS1 with unaltered expression in neighboring neurons leads to a strong reduction in the number of fusion-competent secretory granules and to a significant decrease of released BDNF following exocytosis in dendrites of CAPS1-deficient neurons. In addition, our results show a reduction in synaptic vesicle turnover after CAPS1 knockdown without affecting the density of active boutons in hippocampal neurons. Thus, our results reveal new functions of endogenous CAPS1 in the BDNF secretory granule life cycle, thereby representing a new mechanism of neuronal plasticity.
Suppression of microtubule assembly kinetics by the mitotic protein TPX2
Authors: Reid Taylor A. , Schuster Breanna M. , Mann Barbara J. , Balchand Sai Keshavan , Plooster Melissa , McClellan Mark , Coombes Courtney E. , Wadsworth Pat , Gardner Melissa K.
Published: February 2016

TPX2 is a widely conserved microtubule-associated protein that is required for mitotic spindle formation and function. Previous studies have demonstrated that TPX2 is required for the nucleation of microtubules around chromosomes; however, the molecular mechanism by which TPX2 promotes microtubule nucleation remains a mystery. In this study, we found that TPX2 acts to suppress tubulin subunit off-rates during microtubule assembly and disassembly, thus allowing for the support of unprecedentedly slow rates of plus-end microtubule growth, and also leading to a dramatically reduced microtubule shortening rate. These changes in microtubule dynamics can be explained in computational simulations by a moderate increase in tubulin–tubulin bond strength upon TPX2 association with the microtubule lattice, which in turn acts to reduce the departure rate of tubulin subunits from the microtubule ends. Thus, the direct suppression of tubulin subunit off-rates by TPX2 during microtubule growth and shortening could provide a molecular mechanism to explain the nucleation of new microtubules in the presence of TPX2.
Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis
Authors: Takemoto Ai , Kawashima Shigehiro A. , Li Juan-Juan , Jeffery Linda , Yamatsugu Kenzo , Elemento Olivier , Nurse Paul
Published: February 2016

Here, we screened a 10,371 library of diverse molecules using a drug-sensitive fission yeast strain to identify compounds which cause defects in chromosome segregation during mitosis. We identified a phosphorium-ylide-based compound Cutin-1 which inhibits nuclear envelope expansion and nuclear elongation during the closed mitosis of fission yeast, and showed that its target is the β-subunit of fatty acid synthase. A point mutation in the dehydratase domain of Fas1 conferred in vivo and in vitro resistance to Cutin-1. Time-lapse photomicrography showed that the bulk of the chromosomes were only transiently separated during mitosis, and nucleoli separation was defective. Subsequently sister chromatids re-associated leading to chromosomal mis-segregation. These segregation defects were reduced when the nuclear volume was increased and were increased when the nuclear volume was reduced. We propose that there needs to be sufficient nuclear volume to allow the nuclear elongation necessary during a closed mitosis to take place for proper chromosome segregation, and that inhibition of fatty acid synthase compromises nuclear elongation and leads to defects in chromosomal segregation.
18F-FDG PET/CT imaging and PET-guided biopsy in evaluation and treatment decision in adrenal histoplasmosis
Authors: Kalathoorakath Renjith Radhakrishnan , Sharma Aman , Sood Ashwani , Nahar Uma , Gorla Arun Kumar Reddy , Mittal Bhagwant Rai
Published: February 2016

Histoplasmosis is a rare opportunistic fungal infection. It is commonly seen in immunocompromised individuals from endemic areas. Adrenal glands are frequently involved in the disseminated disease. Here, we present the case of a retropositive patient with constitutional symptoms, where whole-body positron emission tomography/CT scan revealed intense 18F-fludeoxyglucose uptake in bulky adrenal glands, and subsequent positron emission tomography-guided biopsy helped in establishing the diagnosis of adrenal histoplasmosis.
Ο ναός του Αγίου Γεωργίου στο ∆ομένικο Ελλασσώνας
Authors: ΒΟΓΙΑΤΖΗΣ Σωτήρης , ΣΥΘΙΑΚΑΚΗ-ΚΡΙΤΣΙΜΑΛΛΗ Βασιλική
Published: February 2016

Κατά τη διάρκεια των ανασκαφικών εργασιών και των εργασιών αποκατάστασης που εκτελέστηκαν από την 7η Εφορεία Βυζαντινών Αρχαιοτήτων από το 1995 ως το 1997, ήρθαν στο φως νέα στοιχεία για την οικοδομική ιστορία του ναού του Αγίου Γεωργίου στο ∆ομένικο. Κατασκευαστικά, τεχνοτροπικά και στρωματογραφικά δεδομένα μαρτυρούν ότι ο ναός ανεγέρθηκε στα ερείπια ενός υστερορρωμαϊκού ναού στα τέλη του 10ου ή τις αρχές του 11ου αιώνα ως επισκοπική έδρα, που διέθετε σύνθρονο, κιβώριο και άμβωνα. Στο δεύτερο μισό του 13ου αιώνα, πιθανότατα με χορηγία του Σεβαστοκράτορα της Θεσσαλίας Ιωάννη Άγγελου Κομνηνού ∆ούκα, ο νάρθηκας επεκτάθηκε προς τα δυτικά προκειμένου να μετατραπεί σε λιτή, καθώς ο ναός μετατράπηκε σε καθολικό μονής. Πολύ αργότερα, οι στέγες του ναού ανακατασκευάστηκαν στη σημερινή ενιαία μορφή τους και οι εσωτερικοί τοίχοι καλύφθηκαν με τοιχογραφικό διάκοσμο που χρονολογείται από επιγραφές στα 1611 και 1615. Κατά τη διάρκεια του 18ου αιώνα ο βόρειος τοίχος του ναού και μέρος του ανατολικού τοίχου του διακονικού ανακατασκευάστηκαν.
The Magic of the Written Word: The Evidence of Inscriptions on Byzantine Magical Amulets
Authors: FOSKOLOU Vicky A.
Published: February 2016

Tο άρθρο μελετά την αποτροπαϊκή χρήση του γραπτού λόγου μέσω των επιγραφών που αναγράφονται σε βυζαντινά φυλακτά, δηλαδή σε προσωπικής φύσης φορητά αντικείμενα, τα οποία απευθύνονταν σε ένα χριστιανικό κοινό και έχουν ένα μαγικό χαρακτήρα, φέρουν δηλαδή παραστάσεις, σύμβολα και επιγραφές που δεν προέρχονται από τις παραδόσεις και τη διδασκαλία της επίσημης Εκκλησίας. Στόχος είναι να διερευνηθούν οι αντιλήψεις που κρύβονται πίσω από τη δημιουργία, κατοχή και χρήση αυτών των τεχνέργων και να αποδειχθεί πως ο λόγος που αναγράφεται σε αυτά τα αντικείμενα έχει τα χαρακτηριστικά μιας τελετουργικής γλώσσας, όπως αυτή ορίζεται σε ανθρωπολογικές και θρησκειολογικές μελέτες.
«...ΑΓΕΤΑΙ... ΓΑΜΕΤΗΝ ΕΚ ΤΗΣ ΕΛΛΑ∆ΟΣ...» (Νικηφόρου πατριάρχου, Ιστορία σύντομος, 77.9-10)
Authors: ΒΟΛΤΥΡΑΚΗ Ελευθερία
Published: February 2016

Σε ανασκαφική έρευνα της 1ης Εφορείας Βυζαντινών Αρχαιοτήτων στη Θήβα, αποκαλύφθηκαν δύο συνανήκοντα θραύσματα αργυρού ενσφράγιστου πινακίου. Στην αφανή πλευρά της βάσης του διατηρούνται δύο σφραγίδες, μία επιμήκη με τοξωτή την άνω πλευρά και μία ορθογώνια. Η μεν πρώτη φέρει προτομή της Ειρήνης Αθηναίας και σταυροειδές μονόγραμμα, ενώ η δεύτερη αναφέρει τον Ιωάννη, βασιλικό (πρωτο)σπαθάριο και χαρτουλάριο του σακελλίου.
Die Bindung des Isaak in der frühchristlichen, jüdischen und byzantinischen Ikonographie: Neue Beobachtungen
Authors: ALTRIPP Michael
Published: February 2016

Tο άρθρο αναφέρεται στην παράσταση της Θυσίας του Αβραάμ και τη σχέση της με την παλαιοχριστιανική τέχνη, την ιουδαϊκή τέχνη της ύστερης αρχαιότητας και τη βυζαντινή τέχνη. Κατά πρώτον ερμηνεύεται η απεικόνιση του Μωυσή πλάι στον Αβραάμ στις παλαιοχριστιανικές σαρκοφάγους, δεύτερον συμπεραίνεται ότι η απεικόνιση της Θυσίας του Αβραάμ στο ψηφιδωτό του δαπέδου της συναγωγής Beth Alpha είναι πιθανώς επηρεασμένη από τη χριστιανική τέχνη και τέλος υποστηρίζεται ότι η παράσταση της Θυσίας του Αβραάμ στην πρόθεση ερμηνεύεται από τη λειτουργία της προσκομιδής.
Oι τοιχογραφίες του ναού της Παναγίας στο Κάδρος, Σέλινο, Νομός Χανίων
Authors: ΞΑΝΘΑΚΗ Θέτις
Published: February 2016

Οι τοιχογραφίες του ναού της Παναγίας στο Κάδρος αποτελούν αξιόλογη επαρχιακή τέχνη της περιόδου της ενετοκρατίας στη δυτική Κρήτη. Η διερεύνηση της εικονογραφίας της τεχνοτροπίας και της τεχνικής τους τις εντάσσει στα έργα της «σχολής» του Ιωάννη Παγωμένου, προσδιορίζει τους αγιογράφους που τις εκτέλεσαν, εντοπίζει τις περιορισμένες δυτικές-σταυροφορικές επιδράσεις, κυρίως στην εικονογραφία τους, και τις τοποθετεί χρονολογικά γύρω στο 1335.
Τέσσερις κρητικές εικόνες - αφιερώματα Μονεμβασιωτών στη Μονή Σίντζας Κυνουρίας
Authors: ΑΓΡΕΒΗ Μαρία
Published: February 2016

Στο άρθρο μελετώνται οι δεσποτικές εικόνες του τέμπλου στο καθολικό της μονής Σίντζας κοντά στο Λεωνίδιο Κυνουρίας, έργα του 1642 και 1645. Πρόκειται για δημιουργίες κρητικού εργαστηρίου ζωγραφικής, οι οποίες τυπολογικά συνδέονται με καλά κρητικά έργα κυρίως του 17ου αιώνα και τεχνοτροπικά με τη σύγχρονή τους συντηρητική τάση της κρητικής ζωγραφικής. Οι παραγγελιοδότες τους κατάγονταν από τη Μονεμβασία, όπως και οι παραγγελιοδότες, την ίδια εποχή, ορισμένων από τις κρητικές δεσποτικές εικόνες του τέμπλου στο καθολικό της μονής Λουκούς κοντά στο Άστρος Κυνουρίας (1639, 1641). Το ενδιαφέρον Μονεμβασιωτών για τις δύο μονές στην Κυνουρία θα πρέπει να συνδεθεί με τις εμπορικές και αγροτικές δραστηριότητές τους στην περιοχή αυτή.
Εικόνα του αγίου Ιωάννη του Θεολόγου στη Χαλκίδα, ένα πιθανό έργο του Θωμά Μπαθά;
Authors: ΠΑΠΑΝΙΚΟΛΑΟΥ Πρόδρομος
Published: February 2016

Η εικόνα από το μητροπολιτικό ναό της Χαλκίδας στην Εύβοια παρουσιάζει μια διαχρονικά σπάνια επιλογή για την απεικόνιση του Θεολόγου, αυτή της μετωπικής προσωπογραφίας. Την κεντρική μορφή συμπληρώνουν σε μικρογραφική κλίμακα η καθήμενη μορφή του Προχόρου στα αριστερά του ευαγγελιστή και στην πάνω δεξιά γωνία της εικόνας το τεταρτοκύκλιο του ουρανού με ακτίνες. Τα εικονογραφικά όσο και τα τεχνοτροπικά του έργου υποδεικνύουν ως πιθανή χρονολόγηση τις τελευταίες δεκαετίες του 16ου αιώνα. Το έργο, ερμηνεύοντας τα στοιχεία που διαθέτει, δύναται να προσγραφεί στον κύκλο των αποδιδόμενων καλλιτεχνημάτων του Θωμά Μπαθά.
Une enseigne de chirurgien à Chype au XVIe siècle
Authors: FRIGERIO-ZENIOU Stella
Published: February 2016

Η τετράγωνη αμφιπρόσωπη εικόνα (40×41,5×4 εκ.), από την εκκλησία της Παναγίας στην Κλήρου (Ιερά Μητρόπολις Ταμασού και Ορεινής) παρουσιάζει στις δύο όψεις την ίδια ακριβώς εικονογραφία σε δύο ίσα οριζόντια διάχωρα: στο πάνω την Παναγία Οδηγήτρια με τους αγίους Αναργύρους, Κοσμά και Δαμιανό, στο κάτω, δύο χειρουργούς που παρέχουν φροντίδα ο ένας σε έναν άνδρα αριστερά και ο δεύτερος σε μια γυναίκα δεξιά. Η εικονογράφηση, καθώς και το τετράγωνο σχήμα της, από το οποίο χάθηκε το φαρδύ πλαίσιο, υποδεικνύουν πινακίδα χειρουργού-φαρμακοποιού, όπως τις γνωρίζουμε και σε πόλεις στη Δύση.
New Evidence on the Dedicatory Inscriptions (13th century) in the Church of Hagioi Theodoroi, Ano Poula, Inner Mani
Authors: KATSAFADOS Panayotis Stam.
Published: February 2016

Η παρούσα μελέτη εξετάζει τις απεικονίσεις των δωρητών και τις συναφείς αφιερωτικές επιγραφές στην εκκλησία των Αγίων Θεοδώρων στην Άνω Πούλα της Μέσα Μάνης. Περιλαμβάνει ό,τι έχει δημοσιευθεί μέχρι σήμερα για το θέμα αυτό και συνεισφέρει παράλληλα στοιχεία από την επιτόπια έρευνα του συγγραφέα, τα οποία μέχρι σήμερα είχαν διαφύγει της προσοχής. Μεταξύ αυτών είναι το σωζόμενο τμήμα από την κύρια αφιερωτική επιγραφή του ναού (13ος αιώνας) και η απεικόνιση του δωρητή.
Ανέκδοτος νομισματικός «θησαυρός» από τον Πριόλιθο Καλαβρύτων
Authors: ΛΑΜΠΡΟΠΟΥΛΟΥ Άννα Ι.
Published: February 2016

Στην Κειμηλιοθήκη της μονής της Αγίας Λαύρας Καλαβρύτων φυλάσσονται δέκα πρωτοβυζαντινά νομίσματα μέσα σε χάλκινη οινοχόη. Το εύρημα συνιστά νομισματικό «θησαυρό», που βρέθηκε το 1977 στη θέση «Κόκκορη» του οικισμού Πριόλιθος (τέως Συρμπάνι), 15 χλμ. νοτιοδυτικά των Καλαβρύτων. Ο «θησαυρός» παραδόθηκε το 2007 στη μονή Αγίας Λαύρας από τον κάτοικο Πριολίθου Αυγερινό Δημητρακόπουλο. Στην παρούσα μελέτη εξετάζεται τόσο το περιεχόμενο του «θησαυρού» όσο και η χρονολόγηση του μετάλλινου αγγείου-θησαυραρίου, προκειμένου να αξιολογηθεί η σημασία του σε σχέση με τον οικισμό στον οποίο βρέθηκε.
Case Report: Elevated CPK, an indicator of idiopathic inflammatory myopathy?
Authors: Khan Hina N. , Jilani Usman , Arora Shitij
Published: February 2016

Polymyositis is a rare disease with incidence rates at about 1 per 100,000 people annually. In this case report we will review a case of proximal muscle weakness with an elevated creatine phosphokinase that was initially misdiagnosed twice as rhabdomyolysis. Therefore, emphasizing that idiopathic inflammatory myopathy is a potential cause of myasthenia that must be considered in the differential. The case will also describe the current treatment and treatment response in polymyositis.
Understanding the nature of health: New perspectives for medicine and public health. Improved wellbeing at lower costs
Authors: Bircher Johannes , Hahn Eckhart G.
Published: February 2016

Background: Current dilemmas of health care systems call for a new look at the nature of health. This is offered by the Meikirch model. We explore its hypothetical benefit for the future of medicine and public health.

Meikirch model: It states: “Health is a dynamic state of wellbeing emergent from conducive interactions between individuals’ potentials, life’s demands, and social and environmental determinants.” “Throughout the life course health results when an individuals’ biologically given potential (BGP) and his or her personally acquired potential (PAP), interacting with social and environmental determinants, satisfactorily respond to the demands of life.”

Methods: We explored the Meikirch model’s possible applications for personal and public health care.

Results: The PAP of each individual is the most modifiable component of the model. It responds to constructive social interactions and to personal growth. If an individual’s PAP is nurtured to develop further, it likely will contribute much more to health than without fostering. It may also compensate for losses of the BGP. An ensuing new culture of health may markedly improve health in the society. The rising costs of health care presumably are due in part to the tragedy of the commons and to moral hazard. Health as a complex adaptive system offers new possibilities for patient care, particularly for general practitioners.

Discussion: Analysis of health systems by the Meikirch model reveals that in many areas more can be done to improve people’s health and to reduce health care costs than is done today. The Meikirch model appears promising for individual and public health in low and high income countries. Emphasizing health instead of disease the Meikirch model reinforces article 12 of the International Covenant on Economic, Social and Cultural Rights of the United Nations – that abandons the WHO definition - and thereby may contribute to its reinterpretation.
Improving quality for maternal care - a case study from Kerala, India
Authors: Vlad Ioana , Paily VP , Sadanandan Rajeev , Cluzeau Françoise , Beena M , Nair Rajasekharan , Newbatt Emma , Ghosh Sujit , Sandeep K , Chalkidou Kalipso
Published: February 2016

Background: The implementation of maternal health guidelines remains unsatisfactory, even for simple, well established interventions. In settings where most births occur in health facilities, as is the case in Kerala, India, preventing maternal mortality is linked to quality of care improvements.

Context: Evidence-informed quality standards (QS), including quality statements and measurable structure and process indicators, are one innovative way of tackling the guideline implementation gap. Having adopted a zero tolerance policy to maternal deaths, the Government of Kerala worked in partnership with the Kerala Federation of Obstetricians & Gynaecologists (KFOG) and NICE International to select the clinical topic, develop and initiate implementation of the first clinical QS for reducing maternal mortality in the state.

Description of practice: The NICE QS development framework was adapted to the Kerala context, with local ownership being a key principle. Locally generated evidence identified post-partum haemorrhage as the leading cause of maternal death, and as the key priority for the QS. A multidisciplinary group (including policy-makers, gynaecologists and obstetricians, nurses and administrators) was established. Multi-stakeholder workshops convened by the group ensured that the statements, derived from global and local guidelines, and their corresponding indicators were relevant and acceptable to clinicians and policy-makers in Kerala. Furthermore, it helped identify practical methods for implementing the standards and monitoring outcomes.

Lessons learned: An independent evaluation of the project highlighted the equal importance of a strong evidence-base and an inclusive development process. There is no one-size-fits-all process for QS development; a principle-based approach might be a better guide for countries to adapt global evidence to their local context.
Mnemotropic and anxiolytic activity of mexidol and enoxifol
Authors: Трегубова  , Tregubova I.
Published: February 2016

The article presents the research findings of influence of antioxidant compounds Enoxifol

(10 mg/kg) and Mexidol (100 mg/kg) on behavior, emotional sphere and ability for self-regulation of experimental

animals. The mechanism of Enoxifol and Mexidol action at high nervous functions was established on the

basis of tests allowing to connect behavior reactions with the main neuromediator systems. In the “open field”

test the emotional labality, stress resistance and research activity were evaluated in control rats and rats treated

for three days by antioxidants. The experiments revealed that Enoxifol diminished aggressiveness, step of domination

and degree of neurotic reactions of animals, increased the resistance to emotional load which was accomplished

by the more firm preservation of the memory track then in intact animals. These changes in high nervous

functions were caused by antiadrenergic, choline- and GABA-positive activity of Enoxifol. Mexidol in turn posessed

mnemotropic effect as well, but hasn’t affected the level of stress resistance in experimental rats. Mexidol

modulated acetilecholine, benzodiazepine and GABA receptors in a brain.
Optimization of complex treatment of acute intestinal obstruction
Authors: Магомедов  , Magomedov M. , Бациков  , Batsikov Kh.
Published: February 2016

Clinical data are based on material obtained during the examination and treatment of 88 patients with different forms of acute intestinal obstruction non-tumor genesis. The subjects were: men – 48 (54.5%), 40 women (45.5%). Low small bowel obstruction was the most common in 61.7% of patients, high level – in 38.3%. Among 88 patients, 29.4% of patients were in the stage of ischemia - reperfusion IPOs, 29.4% of patients with volemic disorders and 41.2% – in the stage of peritonitis. 42 patients of the main group received complex postoperative therapy, and endolymphatic administration of Cytoflavin and Sulodexide. The patients of comparison group had standard treatment. The clinical results indicate that the use of endolymphatic drug therapy in complex therapy of acute intestinal obstruction allows to optimizing the course of early postoperative period. Postoperative complications decreased in 9.7%; the mortality in 5.7%; and rate of bed – days at 3. Comparative characteristics proved that endolymphatic drug therapy provides adequate correction of immunological disorders, reducing the intensity of lipid peroxidation. The reduction of hypoxia was recorded in the main group. The content of lactic and pyruvic acids in plasma, respectively, is decreased by 9.8 and 14.8%. The results show that the use of Cytoflavin and Sulodexide results in strengthening the integral response of the immune system.
Mathematical modeling of immunological parameters for the prediction and diagnosis of chronic non-communicable diseases among health care workers
Authors: Рогалев  , Rogalev K. , Шишова  , Shishova A. , Мартынова  , Martynova N. , Басова  , Basova L. , Ермолина  , Ermolina Tatyana , Родионов  , Rodionov G.
Published: February 2016

This article presents a mathematical method of interpretation of immunological parameters of

blood. The study used a comprehensive evaluation of the possibility of disease development, not only on the

basis of qualitative data, directly gender-related characteristics and professional activities (occupation, profile,

department, work with the equipment), but also quantitative data - age, work experience, immunological indicators

of the level of immune protection of the subject. The analysis of multidimensional data allowed to identifying

immunological symptoms as predictors of chronic non-communicable diseases. The risk of chronic noncommunicable

diseases among the health care workers is the largest extent dependent on exposure to occupational

factors. The proposed method is the mathematical interpretation of immunological indices of blood, it allowed

to reveal immunological symptoms as predictors of chronic non-communicable diseases. The immunologВЕСТНИК

НОВЫХ МЕДИЦИНСКИХ ТЕХНОЛОГИЙ – 2015 – N 4

Электронный журнал

Библиографическая ссылка:

Т.А. Ермолина, А.В. Шишова, К.К. Рогалев, Н.А. Мартынова, Л.А. Басова, Г.Г. Родионов Математическое модели-

рование иммунологических показателей для прогнозирования и диагностики хронических неинфекционных заболе-

ваний у медицинских работников // Вестник новых медицинских технологий. Электронное издание. 2015. №4. Пуб-

ликация 1-1. URL: http://www.medtsu.tula.ru/VNMT/Bulletin/E2015-4/5221.pdf (дата обращения: 27.11.2015). DOI:

10.12737/16163

ical detection of the symptom of a health worker at the health screening can be considered as a possible predisposition

or the presence of chronic non-communicable diseases and the subsequent development of complex

diagnostic and therapeutic measures. The health assessment can be carried out not at the stage of identifying already

clinically developed chronic non-communicable diseases, and at the initial stage of the disease. This approach

is feasible due to the fact that the initial reversible disorders. Complex timely preventive and therapeutic

measures can prevent the development of chronic non-communicable diseases.
Modern assessment methods of the effectiveness of chewing phases in orthopedic treatment (literature review)
Authors: Васильева  , Vasileva T. , Митин  , Mitin N. , Гришин  , Grishin M.
Published: February 2016

In this literature review details the diversity of methods for determining the chewing efficiency,

currently existing in the dental practice. Chewing is one of the main functions of the dental system, determine its

condition. Chewing efficiency largely depends on the state of the entire dentition. Therefore, the quality of orthopedic

treatment at different stages of permissible assessed using various methods for determining the efficiency

of chewing. The article discusses in detail current methods of assessing the function of chewing phases of

orthopedic treatment. A brief description of the nature of each method definition chewing efficiency, according

to the classification is presented in the literature. A comparative characteristic of the positive and negative aspects

of the known methods is carried out. The authors assess their labor intensity, sensitivity, availability and

distribution, diversity and quality of the used test material. A special place is the consideration of modern methods,

based on an assessment of the effectiveness of chewing area of occlusal contact with the various techniques

of computerized data analysis. The authors do attempt to explore the possibilities of various systems of

computerized analysis of occlusion for the assessment of chewing efficiency, taking into account the accuracy of

individual features and occlusal relationship. They emphasize efficiency, high precision of the studied method

and the need for further development of this direction in the dental practice.
Immunological aspects of pathogenetic therapy of genital herpes by intravenous laser light of blood
Authors: Зиганшин  , Ziganshin O. , Москвин  , Moskvin S. , Гизингер  , Gizinger O. , Шеметова  , Shemetova M.
Published: February 2016

Chronic recurrent herpes virus infection of the genitals caused by the herpes virus type 2 is an

inflammatory polyetiological disease, in the pathogenesis of which the reduction of non-specific resistance of the

organism, an imbalance of immune factors plays an important role. Treatment of genital herpes infection should

cover all the links of pathogenesis, including immunological. Clinical and immunological assessment of the effectiveness

of intravenous laser light of blood in the UV spectral range (wavelength 365 nm, the device "Lasmik-

VLOK") was carried out. This study involved 79 women at the age of 29,9±0,2 years with clinical signs of

chronic recurrent genital herpes.

Etiotropic therapy was conducted with the use of the Aciclovir in a dose of 500 mg once a day for 6

months. The complex therapy included the use of laser ultrasonic irradiation of blood simultaneously with the

application of standard methods of treatment. The results of the study indicate the presence of positive clinical

dynamics and immune-modulating activity of laser ultrasonic spectrum, that allows to recommend this method

in complex therapy of chronic recurrent genital herpes.
Lipid peroxidation and antioxidant system in patients with acute мyocardial infarction and diabetes mellitus type 2
Authors: Загородняя  , Zagorodnyaya T. , Корниенко  , Kornienko E. , Иванов  , Ivanov D.
Published: February 2016

Problems of the treatment of comorbid patients in routine clinical practice remain highly relevant.

One of the most common combinations – coronary heart disease and diabetes mellitus type 2. In this article,

the authors present their own experience of studying the effects of infusion of the drug "Reamberin" at the

stage of percutaneous coronary intervention on the dynamics of indicators of lipid peroxidation in patients with

myocardial infarction with diabetes mellitus type 2. This study consists of the examination and treatment analysis

of 54 patients, men aged 64,3 ± 6,8 years old with coronary heart disease and clinical manifestations of acute

myocardial infarction and concomitant diabetes mellitus type 2. The percutaneous intervention was made of this

group of patients. To determine the normal values of the studied parameters, the examination of 34 patients with

coronary heart disease without exacerbation (men aged 62,5 ± 4,2 years) with concomitant diabetes mellitus type

2, was carried out. It is found that the development of acute myocardial infarction in patients with diabetes type 2

is accompanied by activation of processes of lipid peroxidation and antioxidant system of blood with a predominance

of lipid peroxidation. It is proved that the use of succinic acid drug "Reamberin" at the stage of percutaneous

coronary intervention in these patients contributes to the decrease in the intensity of free radical processes

and increases the activity of enzymatic antioxidants.
A comparative analysis of cerebral asymmetry according to data from perfusion computed tomography in infarctions of the cerebral hemispheres and dyscirculatory encephalopathy
Authors: Сеинова  , Seinova L.
Published: February 2016

Currently a problem of timely diagnostics and treatment of disorders of cerebral circulation is one of the most important for medicine, as strokes and chronic brain ischemia occupy a significant place among the diseases leading to mortality and disability of population. Computed tomography is one of the leading diagnostics of cerebro-vascular disorders. Today, the diagnostic capabilities of perfusion computed tomography, especially in the field of subtle changes in perfusion in infected and in the contralateral hemispheres of the brain are poorly understood and aren’t used in full. The relevance and scientific novelty of this research is not in doubt. Based on the data of 87 patients with ischemic infarction of the cerebral hemispheres of the brain and vascular encephalopathy, a comparative analysis of blood flow in the affected and contralateral hemispheres, was carried out. The degree of asymmetry of blood flow depending on the phase of development of ischemic stroke and chronic brain ischemia was evaluated. The studies have shown that the relative indicator of inter-hemispheric asymmetry is reduced in the course of development of cerebral infarction, reaching minimum values of dyscirculatory encephalopathy. The author substantiates the practical use of the proposed indicator of inter-hemispheric asymmetry in the evaluation of the degree of chronic ischemic disturbances of cerebral blood flow.
Psychological corrective method of the emotional state in a pregnant woman on dental examination
Authors: Голикова  , Golikova A. , Анисимова  , Anisimova N.
Published: February 2016

Dental treatment of a pregnant woman plays an important role in normal course of pregnancy

and fetal development. It is proved that there is a relationship between the foci of chronic infection in the oral

cavity and a chronic sepsis development of the fetus and the expectant mother. According to the order of the

Ministry of health of the Russian Federation from November 1, 2012 № 572н "On approval of the procedure of

medical aid in the field of "Obstetrics and Gynecology" (except, the assisted reproductive technologies)", the

dental examination of pregnant women is carried out 2 times during the entire pregnancy. Often pregnant women

experience intense fear, excitement and tension before dental interventions, because of this, they can postpone

the visit to the dentist that, in turn, will affect the deterioration of the oral cavity and cause exacerbation of

chronic infection foci. In outpatient dental practice there are known pharmacological and psychological distress

correction methods, their efficiency is proven by objective methods of research. However, the use of pharmacological

agents during pregnancy is not always prescribed and secure, therefore, the authors justify the use of psychological

distress correction methods, including cognitive behavioral methods of psychotherapy, the effectiveness

of their application is impossible without taking into account individual characteristics. To develop a new

method of anxiety correction before dental treatment, the authors took into account the temperament of a pregnant

woman. To ensure a safe and effective dental treatment it requires using a distress correction and motivation’s

formation for treatment adherence, including methods of behavioral psychotherapy. The effectiveness of

the developed method is determined subjectively by testing the level of situational anxiety according to the scale

Spielberg-Hanin. It is found that the use of this method increases the safety of dental treatment for the pregnant woman and the unborn child. This article presents the results of the developed psychological distress correction

method for pregnant woman before dental interventions.
Clinical and microbiological evaluation of the effectiveness of modern phyto- and antibacterial drugs in the early postoperative period after dental implantation
Authors: Ромащенко  , Romashchenko V. , Мануйлов  , Manuylov B. , Дробышев  , Drobyshev A. , Пивоваров  , Pivovarov N. , Гречишникова  , Grechishnikova O.
Published: February 2016

Prescription of antibacterial drugs for patients after operation of dental implantation remains

the main method of prevention of postoperative complications. Despite the correct the postoperative period,

these drugs have several side effects, and in some cases the use of antibiotics is contraindicated due to the presence

of allergic reactions. The study involved 20 patients of different ages (from 25 to 70 years) without the comorbidity or at the

stage its compensation accompanied allergic history and of odontogenic infection foci. Dental implantation was

carried out due to the complete or partial absence of teeth. In the postoperative period antibiotic therapy and

modern herbal drugs were prescribed to patients. The modern herbal drugs were the "Tonzinal" and the plates

«ЦМ-1», consisting of medicinal plant extracts obtained using innovative technologies that allow to select targeted

water-soluble therapeutic substances at the molecular level.

The study consists of evaluation the dynamics of subjective feelings of patients, clinical healing, as well

as the degree of contamination of the wound pathogenic microflora.

In the early postoperative period after dental implantation, the healing occurred by primary intention,

without dehiscence and inflammation in patients of both groups (in the first – antibiotics therapy, in the second -

application of modern herbal drugs). The analysis of microbiological studies in patients of both groups proved

the reduction in the degree of contamination of the wound surface by opportunistic pathogens. The results defined

high efficiency of modern herbal drugs.
Some features of organism response on local administration of reactive oxygen
Authors: Перетягин  , Peretyagin P. , Ковалева  , Kovaleva L. , Перетягин  , Peretyagin S. , Мартусевич  , Martusevich A. , Лучникова  , Luchnikova E.
Published: February 2016

The purpose of this work is the study of microcirculation state at different local effects of reactive

oxygen species on animal tissues. The experiment was performed on 60 healthy white Wistar rats. Control

group (without any manipulations) included 20 Wistar rats. Also 4 main groups were formed (10 rats in each).

Rats of the first group (n=10) were intracutaneously injected with 1 ml of oxygen (in the back), a local darsonvalization

during 4 min. was carried out in animals of the second group (n=10). In third group (n=10) the injection

of 1 ml of oxygen-ozone mixture was made, in the fourth group (n=10) - darsonvalization during 4 min. after a

preliminary introduction of oxygen (1 ml). Microcirculation parameters were tested by laser Doppler flowmetry

with LAKK-02 device. It was defined, that local effects of reactive oxygen species include microcirculation

changes, depending from specialties of exposed factor.
Dynamics of parameters of bioelectrical activity of muscles in response to different static forces
Authors: Горбунов  , Gorbunov D. , Эльман  , Elman Kseniya , Гавриленко  , Gavrilenko T. , Черников  , Chernikov N.
Published: February 2016

This article presents the methods of analysis of the dynamics of bioelectrical activity of the

flexor muscles of the little finger of his right hand as a reaction to the static force in compression dynamometer,

manifested in changes of the quasi-attractors parameters. The main research methods were deterministicstochastic

methods and methods of the chaos theory and self-organization to describe complex biological systems.

The authors present a comparative analysis of calculating the parameters of the obtained results, in particular,

in the framework of the chaos theory and self-organization - the calculations of the phase plane and their

areas; in the framework of the deterministic-stochastic approach - the calculation of the Shannon entropy. Calculations

are aimed at assessing the level of randomness of the recorded signal. Analysis of the recorded signal and

the evaluation of the level of randomness in a signal of bioelectrical activity of muscles showed that an increase

in the static load quasi-attractors bioelectric muscle activity increases dramatically. The degree of change was

estimated by calculating the parameters of quasi-attractors according to the chaos theory and self-organization.

The changes of state of the system in the direction of increasing the degree of variability in the bioelectric activity

of the extensor muscles of the little finger are demonstrated.

The high efficiency of application of the chaos theory and self-organization in the assessment of the neuromuscular

human system is showed. The obtained results allow to determining the level of the ability of performing

the specified operations under the influence of static loads.
The analysis of parameters quasi-attractors of meteofactors as a homeostatic system
Authors: Проворова  , Provorova O. , Филатова  , Filatova O. , Русак  , Rusak S. , Камалтдинова  , Kamaltdinova K.
Published: February 2016

Climatic and ecological environmental factors constitute the objective and subjective sides of

life quality. The influence of weather and climate for health is very important. As the complex system is considered

a model of 3-dimensional phase space, a box, inside of this is a quasi-attractor behavior parameters of meteo

environment. The paper deals with the comparative analysis of the dynamics of meteorological factors of

environment in the phase space of states in the framework of the theory of chaos and stochastic laws. The authors

used their own program on the example of two territorial zones - an average strip of Russia and the Northern

territory (n. Nizhnesortymsky Khanty-Ugra). It is important to note that the air temperature as an essential

feature, it is practically not manifested itself in assessing the importance of parameters for Samara in contrast to

Nizhnesortymsk. The used method allowed to determine the parameters of the order and to their ranking and to

identify the most important characteristics in a comparative perspective the two territorial zones. It was postulated

the equality between weather a climate parameters and cardio-vascular system parameter. It is postulated

that the dynamics of meteorological parameters is similar to the dynamics of the cardiovascular system.
Oxidative stress and hemorheology in patients myocardial infarction with type 2 diabetes
Authors: Гончарова  , Goncharova E. , Ойноткинова  , Oynotkinova O. , Корниенко  , Kornienko E. , Иванов  , Ivanov D.
Published: February 2016

This paper highlights the influence of the intensity of the oxidative stress on hemorheology parameters

in complicated and uncomplicated acute myocardial infarction in patients with diabetes type 2. The

study was performed by analyzing the results of examination and treatment of 66 patients, men aged 65,6 ± 5,8

years old, suffering from coronary heart disease with clinical manifestations of acute myocardial infarction and

concomitant diabetes type 2. Depending on the presence of acute heart failure patients were divided into 2

groups. 1st group consisted of 34 patients with myocardial infarction without complications, Group 2 - 32 patients

who have myocardial infarction complicated by acute heart failure (II-III class classification T.Killip).

Condition pro- and antioxidant systems were evaluated for 3 days by determining in the blood of patients

diene conjugates, malonic dialdehyde, α-tocopherol, ceruloplasmin, calculated coefficient of oxidative stress.

The rheological properties blood evaluated by the blood coagulation time, the hematocrit, amount the fibrinogen

in the blood, and blood plasma viscosity, red blood cells deformability index, the aggregation of red blood cells

and thrombocytes. The values obtained were compared with data from 32 healthy donors.

It is revealed that the development of congestive heart failure in acute myocardial infarction in patients

with diabetes type 2 is accompanied by activation of lipid peroxidation (LPO) by maintaining a high level of

primary lipid peroxidation products. Insufficient activity of antioxidant defense can limit oxidative processes,

and leads to their further growth. The damaging effect of lipid peroxidation in the cell membranes is reflected in violation of aggregation and blood viscosity indexes.
Classification, Ranking, and Top-K Stability of Recommendation Algorithms
Authors: Adomavicius Gediminas , Zhang Jingjing
Published: February 2016

Recommendation stability measures the extent to which a recommendation algorithm provides predictions that are consistent with each other. Several approaches have been proposed in prior work to defining, measuring, and improving the stability of recommendation algorithms. Previous studies have focused primarily on understanding and evaluating recommendation stability in prediction-oriented settings, i.e., recommendation settings where it is crucial to provide the precise prediction of a user’s preference rating for an item. However, the research literature has been largely silent on the topic of recommendation stability in other important types of settings, such as classification-oriented (i.e., where it is important to accurately classify the item as relevant versus irrelevant, without having to quantify the user’s preference precisely), ranking-oriented (i.e., where it is important to provide accurate relative ranking of items to users), or top-K oriented (i.e., where it is important to suggest K items that are most appealing to the user). Therefore, this paper builds on prior work by generalizing the notion of stability to a broader set of recommendation settings and developing corresponding stability metrics. The paper also provides a comprehensive empirical analysis of classification, ranking, and top-K stability performance of popular recommender algorithms on real-world rating data sets under a variety of settings.
Dual Inequalities for Stabilized Column Generation Revisited
Authors: Gschwind Timo , Irnich Stefan
Published: February 2016

Column generation (CG) models have several advantages over compact formulations: they provide better linear program bounds, may eliminate symmetry, and can hide nonlinearities in their subproblems. However, users also encounter drawbacks in the form of slow convergence, also known as the tailing-off effect, and the oscillation of the dual variables. Among different alternatives for stabilizing the CG process, Ben Amor et al. [Ben Amor H, Desrosiers J, Valério de Carvalho JM (2006) Dual-optimal inequalities for stabilized column generation. Oper. Res. 54(3):454–463] suggest the use of dual-optimal inequalities (DOIs) in the context of cutting stock and bin packing problems. We generalize their results, provide new classes of (deep) DOIs, and show the applicability to other problems (vector packing, vertex coloring, bin packing with conflicts). We also suggest the dynamic addition of violated dual inequalities in a cutting-plane fashion and the use of dual inequalities that are not necessarily (deep) DOIs. In the latter case, a recovery procedure is needed to restore primal feasibility. Computational results proving the usefulness of the methods are presented.
Robust Critical Node Selection by Benders Decomposition
Authors: Naoum-Sawaya Joe , Buchheim Christoph
Published: February 2016

The critical node selection problem (CNP) has important applications in telecommunication, supply chain design, and disease propagation prevention. In practice, the weights on the connections are often uncertain or hard to estimate. For this reason, robust optimization approaches have been considered recently for CNP. In this article, we address very general uncertainty sets, only requiring a linear optimization oracle for the set of potential scenarios. In particular, we can deal with discrete scenario based uncertainty, gamma uncertainty, and ellipsoidal uncertainty. For this general class of robust critical node selection problems, we propose an exact solution method based on Benders decomposition. The Benders subproblem, which in our approach is a robust optimization problem, is efficiently solved by applying the Floyd-Warshall algorithm. The presented approach is tested on 384 instances based on Forest-Fire, Barabási-Albert, Erdős-Rényi, and Watts-Strogatz graphs with different number of nodes and edges, where running times are compared to CPLEX being directly applied to the robust problem formulation. The computational results show the advantage of the proposed approach in handling the uncertainty thus outperforming CPLEX most notably for the ellipsoidal uncertainty cases.
IBM Predicts Cloud Computing Demand for Sports Tournaments
Authors: Baughman Aaron K. , Bogdany Richard , Harrison Benjie , O’Connell Brian , Pearthree Herbie , Frankel Brandon , McAvoy Cameron , Sun Sandy , Upton Clay
Published: February 2016

The rapid growth of the Internet and of mobile and other smart technologies has generated increased demand on digital platforms, which are supported by enterprise cloud-computing capabilities. To support IBM’s leadership in analytics, mobile, and cloud technologies, a small team within IBM Global Technology Services (GTS) developed a system that uses advanced analytics to address the dynamic and unpredictable Web traffic patterns produced by a digital-enterprise workload, while driving greater operational efficiencies in computing and labor resources. Current cloud platforms are reactive; that is, they require human intervention to scale computing resources to meet demand. To address this shortcoming, the GTS team developed the Predictive Cloud Computing (PCC) system. PCC uses multiple advanced analytical techniques, such as novel numerical analysis techniques, discrete-event simulation, and advanced forecasting to produce models that forecast Internet traffic demands in near real time, allocating computing resources as needed. In 2014, GTS applied the PCC system across tennis and golf sporting tournaments reducing our cloud-computing hours by about 50 percent, while driving a reduction in labor through automation. The PCC system continues to expand IBM’s technology base; since its inception, it has resulted in 16 patent filings, strengthening IBM’s analytics patent portfolio and overall brand.