bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional and Inflammatory Indicators Aid in Differentiating Benign from Malignant Ovarian Neoplasms: Development and Validation of a Nomogram
Authors: Song Zixuan , Wang Xiaoxue , Wang Yuting , Chen Xueting , Zhang Dandan
Published: June 2024

Background: This study aims to evaluate the effectiveness of the Naples Prognostic Score (NPS), Systemic Inflammation Score (SIS), and Controlling Nutritional Status Score (COUNT) in distinguishing benign from malignant ovarian neoplasms. Additionally, a nomogram is developed utilizing these nutritional and inflammatory indicators to enhance preoperative assessment of ovarian neoplasms. Methods: Patients with ovarian neoplasms who underwent surgery at Shengjing Hospital of China Medical University between June 2017 and June 2022 were retrospectively analyzed. Benign ovarian disease or epithelial ovarian cancer (EOC) was diagnosed postoperatively by pathology. Patients were randomly divided into training and test cohorts. Univariate and multivariate logistic regression analyses were conducted to identify significant clinical and imaging risk factors, along with NPS, SIS, and COUNT. Nomograms were constructed to predict EOC and externally validated. Diagnostic accuracy was assessed using decision curve analysis (DCA) and the area under the receiver operating characteristic (ROC) curve (AUC). Results: A total of 2226 patients (1788 benign and 438 EOC) were included. Factors such as age, multilocular tumors, solid nodules, larger tumor diameter, ascites, and higher tumor marker levels were associated with an increased risk of EOC. The AUC values for models incorporating NPS, SIS, and COUNT were 0.907, 0.897, and 0.883, respectively, indicating superior diagnostic ability compared to models without nutritional/inflammatory indicators. The nomogram with NPS demonstrated the highest diagnostic value and clinical utility based on DCA (p < 0.001). External validation confirmed good agreement between the predicted and observed values. Conclusions: The model including NPS exhibited superior diagnostic value for preoperative diagnosis of EOC compared to models with SIS or COUNT. The nomogram combining NPS with clinical and imaging indicators displayed the highest diagnostic value and efficacy.
Crosstalk between Endoplasmic Reticulum Stress and Ferroptosis in Liver Diseases
Authors: Huang Meiling , Wang Yao , Wu Xiaowei , Li Wenyuan
Published: June 2024

The endoplasmic reticulum (ER) played an important role in the folding, assembly and post-translational modification of proteins. ER homeostasis could be disrupted by the accumulation of misfolded proteins, elevated reactive oxygen species (ROS) levels, and abnormal Ca2+ signaling, which was referred to ER stress (ERS). Ferroptosis was a unique programmed cell death model mediated by iron-dependent phospholipid peroxidation and multiple signaling pathways. The changes of mitochondrial structure, the damage of glutathione peroxidase 4 (GPX4) and excess accumulation of iron were the main characteristics of ferroptosis. ROS produced by ferroptosis can interfere with the activity of protein-folding enzymes, leading to the accumulation of large amounts of unfolded proteins, thus causing ERS. On the contrary, the increase of ERS level could promote ferroptosis by the accumulation of iron ion and lipid peroxide, the up-regulation of ferroptosis related genes. At present, the studies on the relationship between ferroptosis and ERS were one-sided and lack of in-depth studies on the interaction mechanism. This review aimed to explore the molecular mechanism of cross-talk between ferroptosis and ERS, and provide new strategies and targets for the treatment of liver diseases.
DUSP1 Mitigates MSU-Induced Immune Response in Gouty Arthritis Reinforcing Autophagy
Authors: Nie Jing , Qiu Hongbin
Published: June 2024

Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation. Activation of the Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome plays a critical role in the onset and progression of GA. Autophagy may have a dual effect on GA with regard to the NLRP3 inflammasome. Therefore, the present study aimed to gain a deeper comprehension of the interaction between autophagy and NLRP3 inflammasome activation is imperative for developing more efficacious treatments for GA. Methods: Peripheral blood monocytes (PBMCs) were first isolated from GA patients and healthy controls and underwent bulk RNA sequencing analysis. Overexpression and knockdown of dual specificity phosphatase 1 (DUSP1) was performed in THP-1 monocytes to investigate its role in the immune response and mitochondrial damage. The luciferase assay and Western blot analysis were used to study the interaction between autophagy and NLRP3 inflammasome activation. Results: Bulk RNA sequencing analysis showed significant upregulation of DUSP1 expression in PBMCs from GA patients compared to healthy controls. This result was subsequently verified by reverse transcription quantitative polymerase chain reaction (RT-qPCR). DUSP1 expression in human THP-1 monocytes was also shown to increase after MSU treatment. Downregulation of DUSP1 expression increased the secretion of inflammatory cytokines after MSU treatment, whereas the overexpression of DUSP1 decreased the secretion levels. Lipopolysaccharides (LPS) combined with adenosine-triphosphate (ATP) led to mitochondrial damage, which was rescued by overexpressing DUSP1. DUSP1 overexpression further increased the level of autophagy following MSU treatment, whereas downregulation of DUSP1 decreased autophagy. Treatment with the autophagy inhibitor 3-Methyladenine (3-MA) restored inflammatory cytokine secretion levels in the DUSP1 overexpression group. MSU caused pronounced pathological ankle swelling in vivo. However, DUSP1 overexpression significantly mitigated this phenotype, accompanied by significant downregulation of inflammatory cytokine secretion levels in the joint tissues. Conclusions: This study revealed a novel function and mechanism for DUSP1 in promoting autophagy to mitigate the MSU-induced immune response in GA. This finding suggests potential diagnostic biomarkers and anti-inflammatory targets for more effective GA therapy.
Studying the Outcomes in Patients with Tricuspid Regurgitation Treated with Valve Repair or Valve Replacement: Interpreting the Survival Pattern on The Long Term by Application of Artificial Intelligence Methods
Authors: Messori Andrea , Trippoli Sabrina , Romeo Maria Rita , Fadda Valeria , Rivano Melania , Spazio Lorenzo Di
Published: June 2024

Background: The reconstruction of individual patient data from published Kaplan-Meier survival curves is a new technique (often denoted as the IPDfromKM method) for studying efficacy in cases where multiple trials are available, and the endpoint is long-term mortality. In patients with tricuspid regurgitation, both valve repair and valve replacement have been proposed to improve prognosis; 6 controlled clinical trials (CTs) have been conducted to compare the two therapeutic options mentioned above. The objective of our analysis was to study these six trials through the application of the IPDfromKM method. Methods: In the present report, we applied the IPDfromKM method to carry out a pooled analysis of these 6 CTs to investigate the effectiveness of valve repair vs valve replacement and to assess the between-study heterogeneity from this clinical material. After reconstructing individual patient data from these 6 trials, patients treated with valve repair were pooled together and their Kaplan-Meier curve was generated. Likewise, patients treated with valve replacement were pooled together and their Kaplan-Meier curve was generated. Finally, these two curves were compared by standard survival statistics. The hazard ratio (HR) was determined; death from any cause was the endpoint. Results: These 6 CTs included a total of 552 patients; in each of these CTs, the patient group treated with valve repair was compared with another group treated with valve replacement. Our statistical results showed a significantly better survival for valve repair compared with valve replacement (HR, 0.6098; 95% confidence intervals (CI), 0.445 to 0.835; p = 0.002). Heterogeneity was found to be significant in the 6 patient arms undergoing replacement, but not in those undergoing valve repair. In valve replacement, the classification of patients in class III or IV of New York Heart Association (NYHA) was the main negative prognostic factor. Conclusions: Our analysis confirmed the methodological advantages of the IPDfromKM method in the indirect comparative analysis of multiple trials. These advantages include appropriate analysis of censored patients, original assessment of heterogeneity, and graphical presentation of the results, wherein individual patients retain an important role.
Midterm Outcomes for Funnel-EVAR
Authors: Aytekin Bahadır , Mola Serkan , Deniz Gökay , Özçelik Sinan , İşcan Hakkı Zafer
Published: June 2024

Background: The funnel technique, the hybrid assembly of a thoracic and abdominal aortic endograft, is advantageous for frail patients where efficient oversizing is not possible for infrarenal wide aortic necks over 34 mm. We sought to determine the advantages and disadvantages of the Funnel-endovascular aneurysm repair (EVAR) technique using 60 mm length thoracic endograft. Methods: This retrospective study included 22 patients, all frail with high comorbidities, who were operated on with the Funnel technique using the 60 mm Lifetech Ankura thoracic endograft, in 7 urgent and 15 elective cases from January 2018. There were no exclusion criteria except having an age <60 years. Primary endpoints were the technical success and early mortality and morbidity; secondary endpoints were late outcomes such as endoleak, migration, late open surgical conversion, successful sac shrinkage, and enlargement at the infrarenal aortic neck diameter. Results: The patients’ mean age was 72.6 ± 7.3 years (62–86 years), with a mean aneurysm diameter of 83.2 ± 16.8 mm and mean infrarenal aortic diameter of 38.7 ± 2.4 mm. There was no early mortality. Technical success was 100%. 21 standard bifurcated and one aorto-uni-iliac abdominal endograft were deployed. The mean fluoroscopy time was 14.3 ± 5.2 minutes. Mean follow-up was 32.8 ± 19.6 months, with no endovascular complications. There was no Type-1a or Type-3 endoleak, migration, infrarenal aortic neck diameter enlargement, or aneurysm sac enlargement. During the follow-up, three patients died, but there was no aneurysm-related mortality. Conclusions: Funnel-EVAR is effective and safe for patients with a wide infrarenal aortic neck diameter when assessing midterm outcomes. Therefore, it should be part of the armamentarium of a vascular surgeon in patients with wide aortic necks >34 mm.
Pengaruh Umur Potong yang Berbeda terhadap Keragaan dan Kandungan Gizi Rumput Odot (Pennisetum purpureum cv. Mott)
Authors: Akbarillah Tris , Hidayat Hidayat , Pardede R.P. , Sianturi A.C. , Gultom D.
Published: June 2024

This research was conducted to determine the performance and nutritional content of Odot grass (Pennisetum purpureum cv Mott) harvested at different ages. Randomized Block Design consisting of 4 replicate groups of soil strata with 3 different cutting age treatments was used. The treatment groups were T1: 45 days after planting (DAP), T2: 60 DAP, and T3: 75 DAP. The parameters observed were the growth performance of Odot grass, including plant height (PH), number of leaves (NL), number of tillers (NT), dry matter production (DMP) and nutrient content. The results showed that PH, NL, NT, and DMP at 75 DAP were higher (P<0.05) than that at 45 DAP. Nutrient content did not differ (P>0.05) among treatments, except crude fat content (CF). It was concluded that the best cutting age was 75 DAP.
 
Key words: Odot, Production, Nutritional Composition
 
ABSTRAK
Penelitian ini bertujuan untuk mengetahui keragaan dan kandungan zat gizi rumput Odot (Pennisetum purpureum cv Mott) yang dipanen pada umur berbeda. Rancangan Acak Kelompok yang terdiri dari 3 perlakuan dan 4 kelompok ulangan strata tanah digunakan. Kelompok perlakuan adalah 45 hari  setelah tanam(HST) (P1), 60 HST (P2) dan 75 HST (P3). Parameter yang diamati adalah keragaan pertumbuhan rumput Odot, meliputi: jumlah daun (JD), jumlah anakan (JA), tinggi tanaman (TT), produksi bahan kering (PBK) dan kandungan zat gizi. Hasil penelitian menunjukkan TT, JD, JA, dan PBK umur 75 HST lebih tinggi (P<0,05) dari pada umur 45 HST. Kandungan zat gizi tidak berbeda (P>0,05) kecuali kandungan lemak kasar (LK). Disimpulkan yang terbaik umur potong 75 HST.
 
Kata kunci: Odot, Produksi, Komposisi Nutrisi.
Peranan Sertifikasi Nomor Kontrol Veteriner terhadap Jaminan Mutu Keamanan Produk Madu Klanceng di Kabupaten Ogan Komering Ulu
Authors: Kasanah Nur , Oktarina Yetty , Efrianti Rini
Published: June 2024

This stuudy aims to analyze the role of Veterinary Control Number Certification (VCN) in ensuring the quality and safety of Klanceng Honey (Trigona sp.) products in Ogan Komering Ulu district. The research method used in this research is qualitative descriptive. The data analysis used in this research is qualitative analysis using Miles Huberman's theory. The respondents in this research were Klanceng Honey Bee Breeders (Trigona sp.) who have VCN Certification. The research results show that the role of VCN Certification is as a quality guarantee for the safety of Klanceng Honey (Trigona sp) products in Ogan Komering Ulu district. The VCN certified Klanceng honey business has provided Klanceng honey products that are ASUH (Safe, Healthy, Whole and Halal). Apart from that, the VCN certificate also plays a role in supervising and monitoring the safety of food of animal origin, as well as tracking problems related to food safety, and as an SOP for a business unit in running its business. It can be concluded that the VCN certified Klanceng honey entrepreneur guarantees that the honey produced is safe, healthy, whole and halal.
 
Key words: Trigona sp., Veterinary Control Number, Ogan Komering Ulu
 
ABSTRAK
Penelitian ini bertujuan untuk menganalisis peranan Sertifikasi Nomor Kontrol Veteriner (NKV) terhadap jaminan mutu keamanan produk Madu Klanceng (Trigona sp.) di kabupaten Ogan Komering Ulu. Metode penelitian ini yaitu deskriptif kualitattif. Adapun analisis datanya berupa analisis kualitatif dengan menggunakan teori Miles Huberman. Respoden dalam penelitian ini Peternak Lebah Madu Klanceng (Trigona sp.) yang memiliki Sertifikasi NKV. Hasil penelitian menunjukan bahwa peranan Sertifikasi NKV adalah sebagai penjamin mutu keamanan produk Madu Klanceng di kabupaten Ogan Komering Ulu. Usaha madu klanceng bersertifikat NKV telah menyediakan produk madu klanceng yang ASUH (Aman, Sehat, Utuh dan Halal). Sertifikat NKV memiliki peran penting dalam mengawasi dan memantau keamanan makanan dari sumber hewan, serta melacak masalah yang terkait dengan keamanan pangan. Selain itu, sertifikat ini juga berfungsi sebagai SOP bagi unit usaha untuk menjalankan kegiatan usaha. Dapat disimpulkan bahwa pengusaha madu klanceng bersertifikat NKV menjamin madu yang dihasilkan aman, sehat, utuh dan halal.
 
Kata kunci: Madu Klanceng, Nomor Kontrol Veteriner, Ogan Komering Ulu.
Daya Dukung Fungsi Lindung Wilayah Ibu Kota Nusantara (IKN)
Authors: Wicaksono Maulana Malik , Widyandini Arifa Marsanda , Choirunnisa  , Salsabhila Melvina Ardela , Fariz Trida Ridho , Jabbar Abdul , Haris Amnan
Published: June 2024

Penajam Paser Utara and parts of Kutai Kartanegara, East Kalimantan regions were selected as the location of the relocation of the National Capital of Indonesia. Significant land use changes have occurred since 2000 until 2023 and potentially affect changes in the carrying capacity of the protected function from before and current development. This study aims to determine the carrying capacity of the protected function in the development area of the Nusantara Capital City (IKN). The study results show that the carrying capacity of the protected function in the Nusantara Capital City area in 2000 resulted in a value of 0.42 while in 2023 it resulted in a value of 0.50. Both values are in moderate condition where in 2000 it was dominated by shrubs while in 2023 it has an increase in land area in the form of plantation forests that dominate the Nusantara Capital City area and the expansion of agricultural land as well as settlements and other buildings.
Efektivitas Keberlanjutan Pukat Cincin (Purse Seine) di Pelabuhan Perikanan Pantai Pulau Baai Bengkulu
Authors: Futra Febby Dwi , Yuwana Yuwana , Johan Yar , Brata Bieng , Bakhtiar Deddy
Published: June 2024

The effectiveness of the sustainability of purse seines at the Baai Island Bengkulu Coastal Fishing Harbor must pay attention to all aspects, namely ecology, economics, technology, social and institutional. The aims of this research are 1) identifying Purse seine fishing gear, 2) analyzing the sustainability effectiveness of Purse seine, and 3) formulating strategies for the sustainability effectiveness of Purse seine. This research was carried out from March to September 2021 located at the Baai Island Coastal Fishing Harbor, Bengkulu. The research method used is a survey method. The data used are primary and secondary data. Respondents as sources of information came from government elements, fishermen and academic elements who used purposive sampling techniques. Data analysis used the Rapid Appraisal For Fisheries (RAPFISH) method. From the research results, it was found that the sustainability effectiveness of purse seines at the Baai Island Bengkulu Coastal Fishing Harbor was at a value of 65.31 (quite sustainable). The sensitive attributes that influence the effectiveness of sustainability are the application of environmentally friendly fishing technology, counseling for fishermen, employment status as a fisherman, and the use of destructive fishing tools. The policy strategy to increase the effectiveness status of the sustainability of Purse seine is carried out by means of the need to implement environmentally friendly fishing technology for Purse seine fishermen, outreach to fishermen who can provide good education to Purse seine fishermen. in the form of science and technology that can be applied by Purse seine fishermen, the welfare of Purse seine fishermen can be achieved if fishermen have employment status as full fishermen, and outreach to Purse seine fishermen regarding the prohibition on the use of fishing gear destructive
Putting it into words: Emotion Vocabulary, Emotion Differentiation and Depression Among Adolescents [PRE-PREINT]
Authors: DeLap Gwyneth , Vine Vera , Santee Angela , Starr Lisa R.
Published: June 2024

Emotion differentiation (ED; the ability to distinguish discrete internal emotion states) may reflect or benefit from knowledge of linguistic labels. The present study uses natural language processing to examine how emotion vocabulary (EV; diversity of unique emotion terms within active vocabulary) relates to ED and depression in an adolescent sample. We tested two competing preregistered (https://osf.io/4j75w/) models regarding the EV-ED link. In the lexical facilitation hypothesis we posited larger EV may inform ED, perhaps resulting in larger EVs being associated with greater ED. In the emotional concision hypothesis, we theorized ED may reflect narrower emotional experiences that are more succinctly labelled, which could result in larger EV being associated with lower ED. A community sample of adolescents (N=241, ages 14-17, predominately White) completed interviews, self-report measures, and ecological momentary assessments as part of a larger study conducted between 2014- 2016. EV was derived using speech samples from transcribed recordings of life stress interviews. In line with the emotion concision hypothesis, EV and ED were inversely related for negative emotions. Moreover, larger negative EV and lower negative ED were each uniquely associated with depression, casting further doubt on whether diverse negative EVs within spontaneous language are fundamentally adaptive for emotional functioning. Replication in more diverse samples is needed to extend generalizability.
Word repetition and isolation are intertwined in children’s early language experiences
Authors: Nencheva Mira L , Schwab Jessica , Lew-Williams Casey , Fausey Caitlin M.
Published: June 2024

Infants experience language in the context of a dynamic environment in which many cues co-occur. However, experimenters often reduce language input to individual cues a priori without considering how children themselves may experience incoming information, leading to potentially inaccurate conclusions about how learning works outside of the lab. Here, we examined the shared temporal dynamics of two historically separated cues that are thought to support word learning: repetition of the same word in nearby utterances, and isolation of individual word tokens (i.e., single-word utterances). In a large database of North American English, we found that word repetition and isolation frequently co-occurred in children’s natural language experiences, and the extent to which they did so was linked to words’ earlier age of acquisition. This investigation emphasizes children’s experiences in time as a way to understand the learning cues in the language environment, which may help researchers build learning theories that are grounded in real-world structure.
IMPLEMENTASI FILOSOFI PENDIDIKAN INKLUSI DALAM SISTEM PENDIDIKAN INDONESIA MENUJU MERDEKA BELAJAR
Authors: utami Ayu Putri
Published: June 2024

Ketika Mendikbud melakukan inovasi dalam kurikulum merdeka belajar, sekolah inklusi juga menjadi salah satu hal yang perlu diperhatikan. Inklusi mengacu pada keyakinan bahwa sistem sekolah dapat menumbuhkan lingkungan terbuka di mana setiap peserta didik dapat diterima. Secara teori, kata inklusi adalah kebalikan dari kata eksklusi.yang berarti bahwa pendidikan inklusi tidak boleh terbatas pada beberapa peserta didik terpilih. Semua peserta didik, termasuk penyandang disabilitas, harus dapat hadir dan diterima dalam kursus reguler, serta berpartisipasi aktif dalam semua kegiatan pembelajaran, sesuai dengan prinsip pendidikan inklusi. Pendidikan inklusi ini menjadi penting karena Indonesia telah memiliki sejumlah peraturan perundang-undangan yang berbasis hak asasi manusia, yang menegaskan bahwa setiap orang memiliki hak yang sama atas pendidikan. Sekolah inklusi bukan sekedar euforia perwujudan hak asasi manusia, tetapi sudah menjadi komoditas kebutuhan setiap manusia terutama yang menyandang predikat ABK. Peserta didik inklusi berasal dari berbagai kondisi, kemampuan dan kapasitas yang berbeda.
Altruistic Behavior in Charitable Giving: A Comparison Between Rational and Emotional Prompts
Authors: Vieira Celso , Wiegmann Alex , Horvath Joachim
Published: June 2024

There is an ongoing debate about whether rational or emotional appeals have a greater influence on moral behavior. The opportunity to donate to a charity provides an applied case to test this influence. Previous studies confirm the power of emotional appeals. For rational appeals, the results are mixed. We present the results of a pre-registered experiment (N=1056) comparing how much participants donate via cash transfers when exposed to five conditions. Three are vignette-based: Narrative presents the testimony of an identified recipient, Argument presents a Singer-style argument for charitable giving, and Facts lists the results of an evaluation of a cash transfer program. The other two conditions are based on perspective-taking exercises with a reasonable donor or a suffering recipient. As predicted, the average amount donated was significantly lower in the control condition than in each of the other five conditions (all ps <.05). Narrative performed best, significantly better than all other conditions except Facts. The success of Facts is surprising given the poor performance of numerical information conditions in other studies. We discuss what features of our design may have contributed to its success, paving the way for a better understanding of how numerical information can influence altruistic behavior.
Impact of Online Learning Platforms on Academic Performance: A Case Study of Rural Schools in Bangladesh
Authors: Juty Salma Akter
Published: June 2024

The study investigates the influence of e-learning platforms in promoting academic efficiency among Bangladeshi rural students by utilizing a paper-based questionnaire on educational ICT and the e-learning experience. The study uses a mixed method through a survey and interview to determine how the online learning platform has been used, its impact, and the challenges the organization might have faced. More specifically, the study intends to identify the level of adoption of online learning platforms in contrast to those in rural schools, along with measuring how online learning platforms affect student examination performance and investigate what problems both rural teachers and students encounter in these deprived areas. This article uses mixed methods to achieve this aim: quantitative academic records and qualitative data from interviews and surveys of students, teachers, and administrators in rural schools in selected parts of Bangladesh.The study established that teachers from rural schools used online learning platforms with significant outcomes towards student academic performance. Still, it points to a list of issues like multiple device access, poor content, and the lack of in-the-moment support for e-skills. Although those are high barriers to overcome, this evidence suggests that such infrastructure and support could improve educational outcomes in rural areas with online learning platforms. Overall, this articulation has effectively brought out the nature of the use of online learning platforms in rural education and provided the grounds that make it successful.
Through a Machine Lens: Case Studies of Computer Vision and Machine Learning in Design Methodology
Authors: Witt Andrew
Published: June 2024

Machine vision (MV) and artificial intelligence (AI) offer strange new augmentations and transformations of how architects perceive and conceptualise both the creation of buildings and the analysis of existing architecture. Seeing through machinic eyes allows architects to amplify their intuitions and engage in a flood of digitally sensed imagery in more quantifiable and extensible ways. Through a series of case studies of projects developed through the design office Certain Measures, this article argues for the potential of machine vision and artificial intelligence in the creative practice of design while situating these new developments in the history of mathematical ways of seeing and conceptualising architecture. These case studies, across large and small scales, combine ideas from human and machine perception and mathematical geometry to create new architectural approaches.
Perceptual Immersion, or What Computer Games Can Be Used for in Architectural Education
Authors: Szmel Justyna , Jasicka Oliwia , Żubryk Klaudia , Auguścik Katarzyna , Kraczla Marta , Marchewka Krzysztof
Published: June 2024

In this case study, the authors suggest that the introduction of computer games to architectural education may contribute to the broadening of architects’ knowledge of the processes connected to sensory perception as well as the development of their perceptual awareness and sensory sensitivity. This thesis will be supported by the analysis of selected factors enabling sensory immersion (namely motor, vision and sound) in several fragments of two games: “Half-Life: Alyx” (3D game in VR technology) and “Five Nights at Freddy’s” (game for a desktop computer platform). The abovementioned competencies are essential in the process of designing both objects and spaces on a different scale and critical in projects for recipients, especially from the so-called spectrum of neurodiversity.
Otimização da comunicação interna e o uso das TIC's em um banco: a ótica dos colaboradores
Authors: Grossi Samantha Rodrigues Barbosa , Hedler Helga Cristina , Souza Eda Castro Lucas de , Lois Nicolas Caballero
Published: June 2024

Essa pesquisa teve como objetivo compreender o estado atual da abordagem da gestão do conhecimento no setor público, utilizando uma análise bibliométrica. Para alcançar esse objetivo, foi realizada uma busca na base de dados Scopus, inserindo os termos "knowledge management" e "public administration", bem como "knowledge management" e "public administration" e "society", com um intervalo de tempo entre 2002 e 2022. Inicialmente, foram encontrados 376 documentos com esses termos. Após aplicar cinco filtros - limitando a seleção a artigos científicos relacionados ao tema, com citações diferentes de zero, inOrdinatio maior que zero e com o intervalo de tempo especificado -, obtivemos uma amostragem final de 18 artigos relevantes para o exame. Os resultados principais indicam a necessidade da gestão do conhecimento no setor público, tanto para promover práticas quanto para otimizar os processos existentes.
Gestão do conhecimento no setor público: uma análise bibliométrica na base de dados scopus
Authors: Frazatto dos Santos Xisto Andre , Gomes Mateus das Neves , Suero Roberta
Published: June 2024

Essa pesquisa teve como objetivo compreender o estado atual da abordagem da gestão do conhecimento no setor público, utilizando uma análise bibliométrica. Para alcançar esse objetivo, foi realizada uma busca na base de dados Scopus, inserindo os termos "knowledge management" e "public administration", bem como "knowledge management" e "public administration" e "society", com um intervalo de tempo entre 2002 e 2022. Inicialmente, foram encontrados 376 documentos com esses termos. Após aplicar cinco filtros - limitando a seleção a artigos científicos relacionados ao tema, com citações diferentes de zero, inOrdinatio maior que zero e com o intervalo de tempo especificado -, obtivemos uma amostragem final de 18 artigos relevantes para o exame. Os resultados principais indicam a necessidade da gestão do conhecimento no setor público, tanto para promover práticas quanto para otimizar os processos existentes.
The “Eternal Dependence of the Maghreb”
Authors: Mackaman-Lofland Catalina
Published: June 2024

The 1930 Centenary of French Algeria celebrated a triumphalist vision of Algerian history that offset France's supposed colonial successes against the long sweep of North African history. Professors of the Faculté des lettres d'Alger played a leading role in elaborating this narrative through a series of historical texts published for the occasion. In them, they drew on prior historical and geographical research to defend the legitimacy of French colonialism across North Africa. Though dominant, their interpretation of North African history was not universally accepted. The following year, it encountered its first substantial critique from within French academia. Viewed together, these competing North African historical narratives reveal French imaginaries of a consolidating African empire—and the possibilities of thinking beyond it—in the interwar period.
The Muslim Consistory that Never Was
Authors: Schley Rachel Eva
Published: June 2024

During the 1860s and early 1870s, a series of decrees famously redefined the legal identity and rights of Algerian Muslims and Jews. These decrees were part of a broader reappraisal of French colonial rule and the implications of France's founding treaty in Algeria, the Convention of 5 July 1830. This article traces the role of Ismaÿl Urbain and his push to gradually regenerate Algerian Muslims by formalizing a relationship between France and Islam, which echoed efforts to integrate Catholic and Protestant settlers and Algerian Jews within French colonial society. Yet, in his effort to safeguard Islam, and Muslim personal status law more specifically, as necessary tools of Franco-Muslim fusion, Urbain inadvertently helped to ensure the long-term marginalization of Algerian Muslims under French rule.
Tract Warfare
Authors: Tuttle Elizabeth
Published: June 2024

Before the 1931 Colonial Exposition and throughout its six-month run, Vietnamese militants in metropolitan France led an extensive anti-imperialist campaign with the exposition as their focal point. Political ephemera was their primary weapon in the war that erupted between activists who disseminated anti-imperialist texts, the newly-arrived immigrants they sought to recruit, and colonial administrators. This article investigates the role that gender played in the relationship between these groups of men by asking: How did normative ideas related to masculinity and race shape the strategies for the production and dissemination of activist texts? To answer this question, I analyze tracts and papillons, arguing that when Vietnamese militants protested the exposition, they contested dominant visions of masculinity that lay at the heart of the French imperial project.
Assessment of Smoking Behaviour of Adolescents in Two Districts of Nepal and Implications of the MPOWER Policy Measures: A Mixed Method Study
Authors: Acharya Jemish , Prutipinyo Chardsumon , Sirichotiratana Nithat , Amnatsatsue Kwanjai
Published: June 2024

Introduction: Tobacco use is the single most preventable cause of death and disease worldwide. This study aimed to assess the smoking behaviour of adolescents in two districts of Nepal and examine the implications of the MPOWER policy on their smoking behaviour.
Methods: An explanatory, mixed-method study was conducted in two districts of Nepal. Qualitative in-depth interviews were conducted among nine participants aged 35-50, representatives of the Ministry of Health, academic institutions, and managers of organisations working in tobacco control, using snowball sampling method. A total of 306 students of age 13-15 years, from six government schools were recruited through simple random sampling method using an adapted version of the Global Youth Tobacco Survey (GYTS). Findings of the qualitative and quantitative study were explained for concurrence and relevance to present overall study findings. Ethical approval was received from the Nepal Health Research Council and Mahidol University.
Results: Findings from the survey reported that a total of 25 (8.10%) of respondents were smokers, from which 13 (4.20%) were current smokers and 12 (3.90%) were ever smokers. Socio-economic status played a crucial role in the smoking behaviour. Although the survey among adolescents indicated an awareness of the policies, there was a lack of cessation services, which was concurrent with the qualitative findings. The interviews recommended improvements in the implementation of policy ban on public smoking, taxation, and availability of cessation services.
Conclusions: The MPOWER policies are not regulated strictly, especially in areas of the ban on public smoking, regulating the selling of cigarettes to adolescents <18 years, and availability of cessation services.
Inhibitory Effect of Oxibiol on the Process of Protein Modification by Water-Soluble Products of Photo-Oxidative Destruction of Bisretinoid A2E
Authors: Dontsov A. E , Aronshtam N. L , Ostrovsky M. A
Published: June 2024

It has previously been shown that heteroaromatic antioxidant oxibiol (N-acetylcysteinate 6-hydroxy-2-aminobenzothiazole) inhibits the process of fructosylation of serum albumin. The aim of this study is to elucidate the inhibitory effect of oxibiol on modification of proteins by photodegradation products of bisretinoid A2E, the main fluorophore of lipofuscin granules in retinal pigment epithelial cells of the human eye. It was shown that unlike a water-soluble fraction fraction from non-irradiated A2E-liposomes, a water-soluble fraction formed after irradiation of A2E-liposomes with visible light significantly modified albumin in a day after incubation at 37°C. Oxibiol in millimolar concentrations effectively inhibited this process. The inhibitory effect of oxybiol could be attributed to its antioxidant activity and the ability to compete with reactive aldehydes formed during the photooxidative degradation of A2E-cardiolipin liposomes. The acute toxicity of oxibiol in mice after intraperitoneal injection was studied, the values of LD 10 and LD 50 were determined. The results obtained demonstrate that oxibiol can be used in pharmacology for preventing and curing diseases associated with the development of oxidative stress in various fields of medicine, primarily in ophthalmology.
SEMI-AUTOMATIC TORQUE MACHINE DAN RUBBER PAD SILICONE GUNA MENGURANGI CACAT PRODUK DAN CYCLE TIME PADA KEMASAN KOSMETIK TWIST REFILL JAR
Authors: Yanuar Hafiz Muchamad , Harmanto Sri , Sugiono Friska Ayu Fitrianti
Published: June 2024

Proses perakitan yang dilakukan pada kemasan kosmetik terdapat beberapa tahapan, diantaranya proses perakitan inner jar kedalam outer jar, penguncian inner jar kedalam outer jar yang dilakukan oleh operator secara manual. Hal tersebut berpotensi inner jar tidak terkunci kedalam outer jar yang disebabkan oleh faktor kelelahan pada operator yang melakukan proses perakitan dalam jumlah banyak. Dengan adanya alat bantu semi otomatis torque machine dengan sistem kontrol elektropneumatik, sehingga dapat mengurangi waktu proses serta mengurangi produk tidak terkunci yang dapat berpotensi menjadi cacat produk. Metode penelitian yang digunakan yaitu metode Root Cause Analysis yaitu mengidentifikasi permasalahan yang terjadi pada proses perakitan inner jar kedalam outer jar serta mengetahui solusi penyelesaian yang terjadi. Hasil penelitian yang dilakukan pada proses perakitan sebelum adanya alat bantu membutuhkan waktu proses 9,15 detik untuk satu kali proses assembly. Setelah adanya alat bantu torque machine didapatkan hasil waktu proses 7,23 detik dengan waktu proses yang telah ditetapkan oleh perusahaan sebesar 8 detik. Sehingga penurunan waktu proses perakitan dapat berkurang hingga 20,9 %.
МАРКЕТИНГОВІ ІНСТРУМЕНТИ ЗАБЕЗПЕЧЕННЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ РЕКЛАМНОГО БІЗНЕСУ У ЦИФРОВОМУ СЕРЕДОВИЩІ
Authors: ЗАЙЦЕВА Олена , ГАВЛОВСЬКА Наталія , ЧУМАК Руслан
Published: June 2024

Стаття присвячена ретельному аналізу маркетингових інструментів, які використовуються для забезпечення економічної безпеки підприємств рекламного бізнесу у цифровому середовищі. Визначено особливості споживання в цифрову епоху і нові можливості для рекламного бізнесу. Здійснено аналіз загальних і специфічних безпекових ризиків у рекламному бізнесі. Запропоновано релевантні маркетингові інструменти забезпечення економічної безпеки підприємств креативної сфери. Виділено основні види загальних і специфічних безпекових ризиків у рекламному бізнесі. Глобальні коливання і циклічний характер розвитку національної економіки. Розвиток технологій і дифузія інновацій. Зміна цінностей, смаків і запитів споживачів. Агресивні дії конкурентів та активність інших агентів ринку. Непередбачені політичні умови і зміни в законодавстві. Ризик невиконання обов’язків перед клієнтами/замовниками (недотримання термінів, інших умов, відповідні штрафи і збільшення витрат). Непрогнозована неплатоспроможність клієнтів/замовників. Необґрунтованість і помилки в планування рекламної кампанії. Недостатня поінформованість про крос-культурні відмінності країн, регіонів, локальних територій, на яких буде відбуватися рекламна кампанія. Репутаційні ризики, кенселинг (культура скасування). Форс-мажорні обставини. Закцентовано увагу, що використання запропонованих маркетингових інструментів дозволить підприємству рекламного бізнесу не тільки успішно функціонувати в мінливих сучасних умовах, але і проактивно, на упередження вживати коригувальні заходи з метою недопущення небезпечної ситуації або провадження цілеспрямованих дій для зниження наслідків можливих ризиків.
Dialéctica de la guerra y la violencia en Nariño y Colombia: Aportes para pensar la paz histórica
Authors: Lasso Urbano Carlos
Published: June 2024

El libro resultado de la investigación desarrollada en el marco de la formación doctoral pretende demostrar que los elementos principales que debe contener la Paz Histórica en una región como la del departamento de Nariño, y en sí en Colombia, son: democracia participativa, justicia social, dignidad humana y presencia integral del Estado. Con lo anterior, se procura exponer el por qué en Colombia y mucho menos en la región nariñense, en ningún momento se ha llevado a cabo la implementación del “Acuerdo de Paz”, pues lo que se firmó en noviembre de 2016 entre el Estado y las FARC-EP fue una rendición condicionada tanto en términos políticos y jurídicos.
Relatos sobre emociones y enfermedad
Authors: Rosero García Luis Carlos
Published: June 2024

La enfermedad del cáncer genera a nivel personal, familiar y social, situaciones complejas de abordar, más aún si estas tienen efectos directos en el contexto escolar. Es el sujeto quien vive la experiencia del cáncer, el encargado de afrontar todo un cúmulo de exigencias, compromisos, responsabilidades y demandas, que procura resolver de la mejor manera, con el fin de sentirse bien consigo mismo y con todos aquellos que le rodean. En tal sentido, el presente libro retoma los hallazgos y horizontes principales que surgieron de forma progresiva a partir de la investigación titulada Emociones en estudiantes con cáncer pertenecientes a las instituciones educativas oficiales del municipio de Pasto (Rosero et al., 2020), porque se apoya en las voces, narrativas, testimonios y reflexiones de sus participantes; esto es, los estudiantes, sus madres y padres de familia, los profesores y directivos escolares que, desde su propio lugar, dan cuenta de la experiencia con el cáncer. La investigación transcurrió bajo dos ejes fundamentales: uno de tipo teórico - conceptual, y el otro, que fue el encargado de definir los lineamientos metodológicos que, a fin de cuentas, deben ir de la mano, de modo que los resultados sean consistentes y permitan aportar a los objetivos que se ha trazado en el estudio. Para delimitar la categoría central de análisis, es importante ubicar el objetivo general de la investigación, planteado en términos de comprender las emociones presentes en un grupo de estudiantes con diagnóstico de cáncer, pertenecientes a las instituciones educativas oficiales del municipio de Pasto. Igualmente, se planteó un propósito de impacto social: contribuir a la construcción del plan de apoyo emocional (PAE) considerado como un referente fundamental para fortalecer la atención pedagógica a la población en condición de enfermedad; así, se determinó unos objetivos específicos, en términos de identificar las emociones básicas, describir las emociones sociales y analizar el proceso de elaboración psíquica, en estudiantes con diagnóstico de cáncer.
Classical Universities in the Scientific and Technological Development of the Russian Empire and the USSR: Leaving the Ivory Tower
Authors: Gribovskiy M. V.
Published: June 2024

The purpose of the article is to characterize the dynamics of changes in the role of classical universities in the scientific and technological development of the Russian Empire and the USSR, from the point of view of their involvement in the development of the real sector of the economy. The relevance of the study is related to the ongoing discussions about the higher education optimal model.

The novelty is determined by the focus of the study, the breadth of the subject in geographical and chronological terms, and the materials used for analysis.

The conducted research made it possible to clarify ideas about the elitist and anti-utilitarian nature of classical universities stemming in part from the principles of the Humboldtian model, the reception of which was carried out in Russia since the 19th century. The components of the activities of the imperial university were established, which ensured its connection with industry and the practical sphere. These components include: the work of some departments (primarily the department of technology), the promotion of ideas of industrial development in Russia by the professors, participation in all-Russian manufacturing (art and industrial) exhibitions, and the implementation of research work by universities commissioned by industrial enterprises; It is shown how during the First World War the emphasis on the practical component of higher education activities increased, for which it itself was not quite ready.

Particular attention is paid to the profound (and not entirely positive) transformation that universities underwent in the first Soviet decades. In the context of decreasing attention to research activities and the “disaggregation” of universities in the early 1930s their potential has weakened noticeably. However, the correction of the scientific and educational policy of the times of the mature Soviet Union and the development of economic contractual issues have already occurred since the 1950s-1960s lead to an increased influence of universities on the development of the real sector of the domestic economy while reducing the share of fundamental research.
An unsupervised anomaly detection framework for smart assisted living via growing neural gas networks
Authors: Ciprian Matteo , Gadaleta Matteo , Rossi Michele
Published: June 2024

In this study, we present a novel framework for detecting anomalies in everyday activities within a smart-home environment. Our method utilizes the growing neural gas (GNG) concept to dynamically adapt to the changing behaviors of monitored individuals, eliminating the need for supervised input. To develop and evaluate our framework, we collected real-life data from environmental sensors that tracked the daily activities of 17 elderly subjects over a continuous two-year period. The proposed approach is highly versatile, capable of detecting a wide range of anomalies associated with daily living activities. We focus on activities that exhibit abnormal duration, frequency, or entirely new behaviors that deviate from established routines. The performance evaluation of our framework revolves around two key aspects: reliability and adaptability. Reliability measures the accuracy of detecting unusual events, while adaptability assesses the system’s ability to accommodate changes in user behavior. This involves recognizing recurrent anomalous behaviors as new norms over time and transitioning from persistent anomalies during an initial phase. Our proposed anomaly detection system demonstrates promising results in real-life scenarios. It achieves good reliability, with true negative rate and true positive rate exceeding 90% and 80% respectively, across all activities and users. Additionally, the system swiftly adapts to new individuals or their evolving behaviors, adjusting within a span of 3 to 7 days for new behaviors.