bluuebunny/crossref_metadata_2025 huggingface dataset:
FUME 2.0 – Flexible Universal processor for Modeling Emissions
Authors: Belda Michal , Benešová Nina , Resler Jaroslav , Huszár Peter , Vlček Ondřej , Krč Pavel , Karlický Jan , Juruš Pavel , Eben Kryštof
Published: January 2024

Abstract. This manuscript introduces FUME 2.0, an open-source emission processor for air quality modeling, documenting the software structure, capabilities, and sample usage. FUME provides a customizable framework for emission preparation tailored to user needs. It is designed to work with heterogeneous emission inventory data, unify it into a common structure, and generate model-ready emissions for various chemical transport models (CTMs). Key features include flexibility in input data formats, support for spatial and temporal disaggregation, chemical speciation, and integration of external models like MEGAN. FUME employs a modular Python interface and PostgreSQL/PostGIS backend for efficient data handling. The workflow comprises data import, geographical transformation, chemical and temporal disaggregation, and output generation steps. Outputs for mesoscale CTMs CMAQ, CAMx, WRF-Chem, and large-eddy simulation model PALM are implemented along with a generic NetCDF format. Benchmark runs are discussed on a typical configuration with cascading domains, with import and preprocessing times scaling near-linearly with grid size. FUME facilitates air quality modeling from continental to regional and urban scales by enabling effective processing of diverse inventory datasets.
Assessment of warm-water coral reef tipping point thresholds
Authors: Pearce-Kelly Paul , Altier Andrew H. , Bruno John F. , Cornwall Christopher E. , McField Melanie , Muñiz-Castillo Aarón Israel , Rocha Juan , Setter Renee O. , Sheppard Charles , Roman-Cuesta Rosa Maria , Yesson Chris
Published: January 2024

Abstract. Warm-water coral reefs are facing unprecedented Anthropogenic driven threats to their continued existence as biodiverse, functional ecosystems upon which hundreds of millions of people rely. Determining the tipping point thresholds of coral reef ecosystems requires robust assessment of multiple stressors and their interactive effects. We draw upon a literature search and the recent Global Tipping Points Revision initiative to consider warm-water coral reef ecosystem tipping point threshold sensitivity. Considering observed and projected stressor impacts we recognise a global mean surface temperature (relative to pre-industrial) tipping point threshold of 1.2 °C (range 0.7–1.5 °C) and an atmospheric CO2 warming threshold of 350 ppm (range 326–400 ppm), whilst acknowledging that interacting stressors, ocean warming response time, overshoot and cascading impacts have yet to be sufficiently assessed but are likely to lower this threshold. These uncertainties around tipping point sensitivities for such a crucially important ecosystem underlines the imperative of robust assessment and, in the case of knowledge gaps, employing a precautionary principle favouring the lower range tipping point values.
Intense rains in Israel associated with the 'Train effect'
Authors: Ziv Baruch , Dayan Uri , Shendrik Lidiya , Vadislavsky Elyakom
Published: January 2024

Abstract. 'Train effect' is defined as a cloud system in which several convective cells pass over the same place in a short time. Trains produce large amount of rainfall, frequently leading to flash floods, reported mainly over North America during spring and summer. Thirty train events were identified, using radar images, calibrated by rain-gauges, for four winters, all associated with Cyprus Lows (CL). The dynamic factors responsible for their formation in Israel were examined, utilizing the ECMWF Integrated Forecast System of 0.1° resolution. Seventeen out of the 30 events share common features. Each one was found at the cold sector in the southern periphery of a CL at its occluded stage, and located in the left flank of a maximum wind belt, where cyclonic shear vorticity exists. The trains cross the Israeli coast near 32.2° N, with a mean length of 45 km, last 1–3 hours, and yield ~35 mm rainfall. The maximum wind belts right of the trains were found to delineate the limit of the precipitative region of the CLs. Unlike classical trains, activated by thermal or frontal forcing, the EM trains that develop in cold air-mass, can be entitled 'cold trains', rather than the classical 'warm trains'.
Factors Associated with First Antenatal Care Visit (K1) in Pregnant Women at The Mungka Health Center, Lima Puluh Kota
Authors: Gunawan Putri , Basyir Vaulinne , Serudji Joserizal
Published: January 2024

Pregnancy is a natural process that occurs to maintain the continuity of human civilization. Pregnant women are included in a vulnerable group so many health problems arise in pregnant women and even cause death. This can be proven by the high maternal mortality rate (MMR) in Indonesia. Indonesia is a developing country where maternal mortality is still a major problem, namely 126 per 100,000 live births. One effort to reduce maternal mortality is to carry out health checks through antenatal services that comply with standards set by the government. The aim of ANC is to prepare the best physically and mentally and save the mother and child during pregnancy, childbirth and the postpartum period, so that during postpartum the mother and child are healthy and normal physically and mentally. This type of research is an analytical survey with a cross-sectional approach. The population in this study was 562 pregnant women in the working area of ​​the Mungka Community Health Center, Limapuluh Kota Regency. The sampling technique is using a proportional stratified random sampling technique. The number of samples in this study was 75 people with a reserve of 10% of the minimum sample, namely 8 people, so the sample in this study was 83 people. The variables used in this study were mother's knowledge of ANC, mother's attitude towards ANC, mother's confidence in ANC, distance between mother's residence and ANC, mother's socio-economic status with ANC, mother's occupation with ANC, support from health workers with ANC, and family support with ANC. ANC. The data that has been obtained will be carried out using Univariate analysis, Bivariate analysis and Multivariate analysis. The results of this research explain that all variables are interrelated and have the same opportunities. The mother's lack of knowledge about ANC influences ANC attitudes and beliefs. Insufficient ANC visits are also associated with the distance to health facilities which is quite far. The socio-economic and employment conditions of pregnant women can support ANC visits but do not strengthen the relationship in carrying out ANC. The competition between health workers means that support from health workers is lacking and good family support is not yet a strong factor in carrying out ANC.

Keywords: Pregnancy, ANC, knowledge, family support, cross-sectional approach
Exploiting BRAF Mutation for Treatment of Malignant Melanoma: A Literature Review
Authors: Chendriadi Vanesya Rizky , Sandhika Willy
Published: January 2024

Malignant melanoma, a deadly type of skin cancer, presents considerable challenges in clinical management. However, the advent of targeted therapies capitalizing on BRAF mutations has ushered in a new era of optimism for treating melanomas. This investigation delves into the utilization of BRAF mutations as a focused approach in addressing malignant melanoma. Anomalously activated RAS-RAF-MEK-ERK signaling, particularly through the prevalent V600E mutation, instigates uncontrolled cell proliferation and survival in melanocytes. Melanoma arises de novo from melanocytes carrying genetic alterations, with RAF mutations being the most common. Mutated RAF genes, notably the V600E mutation, induce dysregulated cell cycle progression, fueling unchecked proliferation. Given that RAF is a pivotal component of the RAS-MAPK pathway, manipulating this pathway emerges as a promising strategy to impede cancer growth. However, not all melanoma cases exhibit RAS mutations, necessitating molecular testing to identify BRAF mutations before initiating targeted therapy. Detecting typically somatic BRAF mutations mandates melanoma tissue as a specimen. The presence of V600E BRAF mutations becomes a crucial factor for employing BRAF inhibitor therapy. This review article underscores the imperative nature of RAF mutation testing in melanoma patients, serving as a predictive tool to determine the cancer's responsiveness to RAF inhibitor treatment. The identification of BRAF mutations offers a targeted therapeutic avenue, instilling fresh hope for personalized and effective interventions in the management of malignant melanoma.

Keywords: skin cancer; melanoma; braf mutation
Fiscal Policy and Unemployment Nexus in Nigeria: An Empirical Analysis (1990–2021)
Authors: R.C. Ejinkonye , S.N. Nwosu , O.C. Ibecheole , M.U. Zakari , Z.M. Momodu , A. Usman
Published: January 2024

ABSTRACT: This study assessed the fiscal policy and unemployment nexus in Nigeria using time series data covering 1990 to 2021. Economic downturn, poor living standard, inadequate employment generation and increasing unemployment rate are sources of concern and worry. Job creation seems not to be getting the needed attention in the scheme of economic policies in Nigeria. The proxies for fiscal policy were: government capital expenditure (GCE), government revenue expenditure (GRE), government external debt (GED) and government total revenue (GTR), while that for unemployment was the unemployment rate. Specifically, this sought to examine the nexus between GCE and unemployment rate, GRE and unemployment rate, GED and unemployment rate, and GTR and unemployment rate. The ex-post-facto research design was used while the hypotheses were tested at 5% significance level. The time series data obtained from the Central Bank of Nigeria statistical bulletin was analyzed using the OLS technique. The test results showed that: GCE had a coefficient of 3.84 and a probability of 0.9893; GRE had -0.000481 coefficient and a probability of 0.6365; GED had 0.000584 coefficient and a probability of 0.1292 while GTR had 0.002070 coefficient and a probability of 0.0000. The probability f-statistic value of 0.000000 showed that proxies for fiscal policy are jointly significant to the unemployment rate. The adjusted R2 and Durbin-Watson values were 86% and 1.798125 respectively. It was recommended that the federal government should: (1) apply her capital expenditure properly and direct it to sectors that will help create more jobs and reduce unemployment rate, (2) make her recurrent expenditure to be supportive of the various government infrastructures, (3) drastically reduce her growing and high debt profile without commensurate job opportunities, (4) use her revenue to drive the economy instead of being applied on non-productive, white elephant projects or misappropriated.
Assessment of Covid 19 Pandemic and its Effect on the Foreign Mission Work of the Nigerian Baptist Convention
Authors: O.O. Kolade , A. Atowoju
Published: January 2024

COVID-19 pandemic that began initially like a pneumonia outbreak in Wuhan, China, later resulted in unprecedented global disruption. This pandemic has affected every facet of human life including religious life. Christian missions, which was experiencing a major shift in missionary sending direction from the global West and North to the reversed global South and East, was also not spared by this pandemic. This study examined the effects of COVID-19 pandemic on the mission work of the Nigerian Baptist Convention in the United Kingdom. The study adopted a descriptive survey design method and purposive random sampling technique to select the respondents. The information and data were gathered through structured questionnaires and interview guides, using electronic means, from members and leaders of the Nigerian Baptist Convention in the United Kingdom. Interviews were conducted among the selected leaders and policy makers in the United Kingdom and Nigeria. The findings revealed that COVID-19 brought about disruptions of conventional missionary and worship methods in the United Kingdom. The study recommends that the Nigerian Baptist Convention does a rework of strategic mission agenda and approaches that can adapt well to the new normal brought by COVID-19 pandemic across the world.
Conflict in Healthcare: Examining the Role of Social Media and Smartwatches on Healthcare Delivery in Among Students of Afe Babalola University, Ado-Ekiti
Authors: A.I. Omotayo , D.K. Adesegha
Published: January 2024

Social media can be an instrument that fosters peace and wellbeing. It can also be used to incubate hatred and fan violence. A man’s health can affect his peace and how he relates and function in the world. Social media ensures the swift flow of information between people irrespective of geographical borders. It is therefore pertinent that accurate information and data be corroborated swiftly so as to prevent misleading information dangerous to the health, peace and wellbeing from spreading to the general public. The research looked into how the social media and smartwatches impact on healthcare management and personal wellbeing. The study was conducted among the postgraduate students of Afe Babalola university Ado Ekiti, Nigeria. The selected sample size for the study comprised of 60 participants who were purposively selected and issued survey questionnaires. The study found out that the social media has led to the rise of false information about health practices among graduate students. The study also found that smartwatches has a positive significant effect on health management among graduate students in ABUAD.
Management of Higher Education Records and Record Keeping for Sustainable Quality Delivery in Captain Elechi Amadi Polytechnic, Rumuola, Rivers State, Nigeria
Authors: Ejimole Aleru Gladys
Published: January 2024

The study investigated the management of higher education records and record keeping for sustainable quality delivery in Rivers State, Nigeria. The study discussed records and records keeping in educational institutions especially, higher education. The article enumerated the purposes or importance of record management in higher institutions; some related literature were reviewed accordingly, theoretical framework was looked into and the study was achieved on record continuum theory by Funke Upward in 1990. The study highlighted some qualities of a good educational record keeping. The study found that good records management contributes significantly to administrators’ work performance and institutional performance in conclusion records keeping in tertiary institutions improves management performance to a very high extent. It was recommended among others that training programmes in the form of workshops, seminars, conferences be provided for administrative staff with regard to good records management in higher education. It is therefore a known fact that when records are well managed, utilized adequately and appropriately in higher institutions execution of management functions are likely to be easy, effective and sustainable.
Intelligent-Based Job Applicants’ Assessment and Recruitment System
Authors: B. I. Ele , A. A. Ele , F. Agaba
Published: January 2024

In recent years, companies faced the challenge of sorting resumes from job applicants, assessing, recruiting, and notifying applicants manually. This study is centered on creating a system that will automate this process and resolve the problems associated with manual recruitment processes. The waterfall model was employed in the analysis and design of the system in this study due to its simplicity and sequential nature. The system was built using PHP programming language and the database was designed using MySQL. In this study, an intelligent-based job applicants’ assessment and recruitment system was developed using artificial intelligence techniques. It brings phenomenal success to Human Resource Management in a very short time. The recruitment process, in general, would experience a foremost modification, delivering rapid, efficient, and cost-effective methods of discovering prospective workers. Numerous opportunities were identified when utilizing this technology in recruitment, which include speeding up the staffing procedure, computerization of responsibilities, and rising detachment. Results obtained during the evaluation display that this method enhances the correctness of toning the right applicants with the right jobs. However, this system is still open to upgrading in the future for any researcher who finds this to be of interest.
An Enhanced Mechanism for Protecting Web Applications from Cross Site Request Forgery (CSRF)
Authors: B. I. Ele.
Published: January 2024

Cross-Site Request Forgery (CSRF) is considered one of the top vulnerabilities in today’s web, where an untrusted website can force the user browser to send an unauthorized valid request to the trusted site. Legitimate users will lose their integrity over the website when the CSRF takes place. So far, many solutions have been proposed for the CSRF attacks such as the referrer HTTP header, custom HTTP header, origin header, client site proxy, a browser plug-in, and random token validation, but in this research, the use of random token validation to solve the problem of CSRF attacks was implemented. The proposed solution in the study used a concept known as Nonce which is a type of random token attached to requests sent over a server. This solution proved to be effective enough to protect and prevent web applications from CSRF attacks. Although no system can be secured against attacks, this study recommends that the random token validation (Nonce) approach of protecting web applications should be adopted by all web applications developers and users to improve on the already established solutions to reduce the chances of attacks on web applications to a very slim percentage, if not eliminated.
Problem Spaces and Algorithms in Data Mining
Authors: B. I. Ele , I. O. Obono , A. A. Iwinosa
Published: January 2024

Data mining has been described severally as the best thing to have happened to data and information management, especially these days that the cost of computing technologies and storage media are falling, data gathering tools becoming varied and very efficient and the boom in network computing becoming very rewarding. The challenges presented by the management and meaningful usage of large data sets have stimulated so much research in data mining. Consequently, the birth of a number of algorithms to provide insights to these big data has equally presented more complications in information processing computing. Therefore, this paper presents different problem spaces in data mining, available algorithms to mine these data and then mapping specific algorithms to specific problem spaces. Analysis of datasets from a typical financial institution suggests that no one algorithm is necessarily better than the other, but all have strengths and weaknesses depending on the particular problem spaces in use.
A Research on Futuristic Magical effect of Oleanolic Acid
Authors: S. Kate Shweta , R. Bhosale Nilesh , D. Potdar Divyani , P. Kondewad Pavan , S. Bhosale Prashant
Published: January 2024

Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound and its derivatives possess several promising pharmacological activities. Here, we aimed to investigate the antioxidant and free radical scavenging properties of ethanolic extracts of Oleanolic acid from Ocimum sanctum. antioxidants entrapped in nanogel or hollow particles, used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays.
In Silico Study of Corticosteroids Drugs
Authors: Kumar A. Kakade Suraj , H. Rohane Sachin
Published: January 2024

Molecular Docking has become an important component of the drug discovery process. Since first being developed in the 1980s, advancements in the power of computer hardware and the increasing number of and ease of access to small molecule and protein structures have contributed to the development of improved methods, making docking more popular in both industrial and academic settings. In this research Molecular Docking we are perform on triamcinolone and methyl testosterone by using Autodock and Discovery Studio software. QSAR study revealsed that substitution of different electron donating or withdrawing group at different position on triamcinolone and methyl testosterone lead nucleus elaborate change in pharmacological activity. Molecular Docking done by substituting or replacing different group at different position affected the potency of drug on addition of hydroxy, Methyl at different position where reduced the potency of triamcinolone while addition of ether or ester group enhance the potency of triamcinolone. In methyl testosterone, introduction of heterocyclic system into a steroidal nucleus in ring A enhances the potency while removal of hydroxy group, addition of O atom reduces the potency.
Taste Masking of Bitter Drugs in Pharmaceutical Suspension: A Review
Authors: Pal Singh Kishan , Dighe Santosh
Published: January 2024

One of the most vital factors in the formulation of medications for children, the elderly, immobile patients, and uncooperative patients is taste, which is mainly controlled by taste buds in the tongue. The biggest challenge for the compounding scientists is to mask the unpleasant and bitter tastes of the pharmaceuticals, which prevent patients from obtaining the full therapeutic benefit of their prescription. In order to increase patient compliance, which ultimately determines the product's economic success, it may be possible to mask the bitter taste of medications. Inclusion complexation, the use of ion exchange resin, mass extrusion, solid dispersions, coating granulation, spray drying, microencapsulation, liposomes, emulsions, and gel formation effervescence are current methods of flavour masking. Active pharmaceutical ingredient (API) taste masking is an area that is constantly developing because of unusual excipients and a variety of techniques.
A Review on Nasal Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs
Authors: Arti C. Ghorpade , Siddheshwar S. S.
Published: January 2024

Neurotherapeutic drugs fail to reach the site of action due to poor bioavailability, poor water solubility, limited permeability, hepatic first-pass metabolism, and the blood-brain barrier. The nasal cavity allows drugs to be delivered directly to the brain, bypassing the blood-brain barrier. The nasal cavity also avoids hepatic first-pass metabolism, enhancing the systemic bioavailability of highly metabolized substances. As a result, most neurotherapeutics have physicochemical properties that necessitate their formulation in lipidic nanosystems as self-emulsifying drug delivery systems (SEDDS). These are isotropic mixes of oils, surfactants, and co-surfactants that, when diluted in water, produce micro or nanoemulsions containing high quantities of lipophilic medicines. SEDDS should prevent drug precipitation at absorption sites, boost permeability through absorptive membranes, and improve labile drug stability against enzymatic activity. When the benefits of SEDDS and the intranasal route for brain delivery are combined, an increase in medication brain targeting and bioavailability might be expected.
PENERAPAN METODE MERONCE DALAM MENINGKATKAN KEMAMPUAN MOTORIK HALUS ANAK USIA DINI KELOMPOK B
Authors: Supriyatin
Published: January 2024

Tujuan penelitian ini adalah untuk mengetahui Penerapan Metode Meronce Dalam Meningkatkan Kemampuan Motorik Halus Anak Usia Dini Kelompok B di TK Siwipeni Cilacap. Menurut pemaparan guru kelas motorik halus anak harus dilatih sedini mungkin agar motorik halus anak tidak kaku dan otot tangan serta jari-jari tangan bisa dengan mudah terkoordinasi dalam memegang suatu benda. Kegiatan yang bisa melatih motorik halus anak usia 5-6 tahun sebagai berikut: anak dapat menggunakan gunting untuk memotong kertas, anak bisa mengambil balok dengan menggunakan 2 jari (ibu jari dan telunjuk), dapat memasang dan membuka kancing baju sendiri, melipat kertas, dan anak dapat melakukan kegiatan meronce dengan memasukan manik-manik kedalam benang. Hasil penelitian mengungkapkan bahwa kegiatan meronce dengan memasukan manik-manik kedalam benang. Peningkatan motorik halus melalui kegiatan meronce dapat dilihat pada hasil penelitian. Pada kondisi awal kriteria sangat kurang berjumlah 0 anak (0%), kurang berjumlah 4 anak (36%), cukup berjumlah 1 anak (9%), dan baik berjumlah 6 anak (55%). Setelah dilakukan tindakan pada siklus I hasilnya pada kemampuan motorik halus melalui kegiatan meronce mengalami peningkatan yang dapat diilihat yaitu untuk kriteria sangat kurang berjumlah 0 anak (0%), kurang berjumlah 3 anak (27%), cukup berjumlah 1 anak (9%), dan baik berjumlah 7 anak (64%). Pada siklus II meningkat pada kriteria baik berjumlah 10 anak (91%), cukup berjumlah 1 anak (9%) dan kriteria kurang, sangat kurang berjumlah 0 anak (0%). Penelitian ini dihentikan sampai siklus II karena sudah memenuhi kriteria indikator keberhasilan. Dengan demikian dapat disimpulkan bahwa melalui kegiatan meronce dapat meningkatkan kemampuan motorik halus anak usia dini.
Plantaciones de especies nativas en la región de Los Ríos: Superficie y esfuerzos realizados.
Authors: Böttcher Jorquera Heidi , Pinto Álvarez Joselyn , Müller-Using Burkhard
Published: January 2024

Se entregan antecedentes y resultados de una encuesta que da cuenta de la importancia de la región de Los Ríos en cuanto a plantaciones de especies nativas en Chile. Se destaca la importancia de esta región en los esfuerzos efectuados para diversificar la producción en el sector maderero, lo que pone en valor tanto la actividad silvicultural como la biodiversidad de la zona centro sur de Chile.
Crecimiento miceliar in vitro de 2 cepas de Grifola gargal en diferentes medios de cultivo y niveles de pH.
Authors: Chung Guin-Po Patricio
Published: January 2024

Se estudió el comportamiento de dos cepas del hongo saprófito comestible Grifola gargal bajo condiciones de cultivo in vitro. Se analiza el crecimiento en diámetro (CD), velocidad media de crecimiento (VMC) y biomasa (B) de cultivos creciendo en los medios PDA (Papa Dextrosa Agar), BAF (Biotina Aneurina ácido Fólico), MYPA (Extracto de malta levadura agar peptona y PGYA (peptona-extracto de levadura-glucosa) y bajo 5 niveles de pH (4,0, 4,5, 5,0, 5,5 y 6,0).  Los resultados indican interacciones estadísticamente significativas entre los factores medio de cultivo y pH para las tres variables medidas. Se observa que, tanto a nivel de cepas como de especie, el medio MYPA con pH 4,5 presenta los valores más altos para CD, VMC y B. Comparaciones entre valores promedios del CD, VCM y B, muestran alta correlación entre estos parámetros para las cepas estudiadas.
Propagación de Carica chilensis, especie endémica, vulnerable y amenazada del norte de Chile: Un avance para su conservación.
Authors: Hernández Cartes José , Silva Soto Sergio
Published: January 2024

Se estudió la propagación sexual y asexual de Carica chilensis (Palo gordo o papayo silvestre), arbusto endémico clasificado como Vulnerable, que se distribuye desde el sur de la Región de Atacama, principalmente en la Región de Coquimbo y más escasamente en la Región de Valparaíso, entre los 0 a 500 msnm. Unos de los principales problemas de esta especie es su baja producción de frutos, implicando una escasa a nula regeneración natural. Sin embargo, técnicas de propagación pueden mitigar o resolver este problema, empleando germoplasma para su conservación ex situ y posterior reintroducción en su hábitat natural. Durante las prospecciones en terreno se identificó 11 poblaciones de individuos adultos. En tres de ellas (Los Vilos, Punta Colorada y Freirina) se recolectó frutos y vástagos, que fueron utilizados para establecer dos ensayos, uno de propagación sexual y otro de propagación vegetativa. En el ensayo 1 se evaluó el efecto de la germinación de semillas en 4 temperaturas de incubación (15, 20, 25 y 30°C), remojadas en 2 concentraciones de ácido giberélico (AG) (0 y 500 mg/L) e incisión en el micrópilo (con y sin incisión). En el ensayo 2 se determinó la respuesta al enraizamiento con 4 concentraciones de ácido indol butírico (AIB) (0, 1000, 3000, 5000 y 10000 mg/L) y dos tipos de material vegetal (juvenil y adulto). En ensayo 1 se observó que los mayores porcentajes de germinación fueron los de semillas tratadas con ácido giberélico por 24 horas e incubación a 15 °C, y los de semillas solo en incubación a 25 °C, registrando 50% y 53% de germinación, respectivamente. En ensayo 2 se observó que para la propagación asexual el porcentaje de enraizamiento alcanzo un 50% con el uso de material juvenil y sin la utilización de la hormona (AIB), no existiendo respuesta de enraizamiento con material recolectado de plantas adultas.
Kewenangan PTUN dalam Menguji Sikap Diam Pejabat Pemerintahan
Authors: Fadli Falih , Ilmar Aminuddin , Ruslan Achmad
Published: January 2024

Undang-Undang Cipta Kerja membawa perubahan terhadap pelaksanaan administrasi pemerintahan di Indonesia. Undang-Undang Cipta Kerja secara tidak langsung mengubah hukum acara dan kompetensi absolut Peradilan TUN karena dalam pasal 175 ayat (6) Undang-Undang Cipta Kerja menghapus frasa pengadilan sehingga PTUN(PTUN) tidak berwenang lagi untuk mengadili permohonan fiktif positif. Penelitian ini bertujuan untuk menganalisis kewenangan PTUN dalam menguji sikap diam pejabat pemerintahan pasca berlakunya Undang-Undang Cipta Kerja dan menganalisis pertimbangan hakim dalam memutus perkara sikap diam pejabat pemerintahan. Penelitian dengan metode penelitian normatif ini, menghasilkan penelitian bahwa meskipun permohonan fiktif positif dihapus oleh Undang-Undang Cipta Kerja, masyarakat dapat mengajukan gugatan onrechtmatige overheidsdaad terkait sikap diam pejabat pemerintah yang merugikan masyarakat dan Majelis Hakim mempertimbangkan bahwa penanganan sengketa sikap diam pejabat pemerintah dapat diajukan di PTUN namun penanganannya tidak dapat menggunakan acara persidangan Permohonan Fiktif Positif melainkan acara gugatan tindakan faktual.
Peran Hamba Tuhan
Authors: Tolip Prisilia Marode , Mudak Sherly , Manafe Ferdinan S. , Rasi Anre
Published: January 2024

Penelitian ini menggunakan pendekatan analisis isi kualitatif. Teknik pengumpulan data dilakukan dengan cara menelaah buku-buku dan artikel jurnal yang berkaitan dengan topik yang dibahas. Teknik analisis data dilakukan dengan analisis isi kualitatif sebagai metode utama dengan pendekatan interpretatif eksegetis terhadap 1 Tesalonika 5:14, yang menekankan pentingnya menasihati orang yang kurang beruntung, menguatkan yang lemah hati, dan bersabar terhadap semua orang. Penulis menyimpulkan bahwa ajaran "menasihati" dalam surat tersebut tidak hanya berkaitan dengan memberikan nasehat, tetapi juga mengandung makna yang lebih luas, yaitu saling membantu dan menguatkan satu sama lain dalam kehidupan iman dan keseharian. Kontribusi yang dapat diberikan kepada pembaca untuk memperoleh pemahaman tentang prinsip pengajaran yang berlandaskan pada iman Kristen, khususnya dalam konteks hubungan antara hamba Tuhan dan jemaatnya serta memberikan inspirasi dan panduan  dalam mengembangkan kepekaan dan empati terhadap sesama serta menerapkan prinsip-prinsip ajaran yang terkandung dalam surat 1 Tesalonika 5:14.
Clinical evaluation of complications after surgical treatment of patella dislocations in dogs: A retrospective study
Authors: Çatalkaya Emine , Yayla Sadık , Altan Semih , Ersöz-Kanay Berna
Published: January 2024

Patellar luxation is one of the important orthopedic problem in dogs. Patellar luxation, which has been accepted as a developmental disorder in recent years, usually occurs medially in small breeds and laterally in large breeds. The aim of this study was to evaluate surgical treatment (femoral trochleoplasty, tibial tuberosity transpositions and imbrication techniques together), postoperative complications, early and late results in dogs with patellar luxation. Thirty–two dogs with grade 3 and grade 4 patella luxation were used in this study. While patellar luxation was treated in all cases, tibia fracture was seen in one dog as the most important complication. During tibial tuberosity transpositions technique, attention should be paid to the cutting process and the tibia should not be weakened. In conclusion, the combined use of femoral trochleoplasty, tibial tuberosity transposition and imbrication techniques can be used for patellar luxation. Complete recovery may not be possible in grade 4 patellar luxations.
Functional morphology of arteriovenous anastomoses on rat ovary
Authors: Çimen Kaan , Çimen Mehmet
Published: January 2024

This study aims to show the morphology of the structure involved in the function of arteriovenous anastomoses (AVA) under electron microscope. The study used 20 adult females of Rattus norvegicus. Ovarian tissue samples were fixed in 3% Glutaraldehyde in phosphate buffer, and then post–fixed in increasing concentrations of Ethanol, tissues were embedded in Epon resin. Semi–thin tissue sections were double stained with Uranyl acetate saturated in 70% Ethanol and lead Citrate. The ultrathin sections were examined in a JEOL 100 C electron microscope. In the opened AVA section, tunica intima, tunica media, and adventitia layers were observed in the vessel wall structure. The endothelial cell was present in the tunica intima, and the lumen was open. Thick layered smooth muscle cells were found in the tunica media. The muscles were arranged inner longitudinally and outer circularly. The internal elastic membrane lies between the circular and longitudinal smooth muscle. In another section taken from the tunica adventitia, fibroblasts were observed between dense elastic and collagen fibrils. The longitudinal smooth muscle was contracted in the closed AVA section, and the lumen appeared in the typical asterisks shape. This study showed the functional morphology of the AVA's and detailed vessel wall structures in the rat ovary. Lumen structure with open and closed AVAs is also shown. With observations from this study, the functional properties of the formations in the AVA wall structure are explained in the rat ovary.
Endocrine disruptors and additives in cosmetic makeup products: Alert to users
Authors: Ngoie Mutunda Jaël  , Kasamba Ilunga Eric
Published: January 2024

Introduction: Cosmetic products contain a wide range of chemicals that we are exposed to daily. The aim of the study was to determine the presence of potentially hazardous substances that could cause adverse health effects by reviewing product labels facilitated by Capture images using Android phone. Materials and methods: In total, 105 makeup products were collected in different stores in the city of Lubumbashi, mainly mascaras, nail polishes, powders, lipsticks, liquid and powder foundations, blush. eyeshadow and blush as well as eyelid pencils. Each product's label was reviewed and a list including additives, preservatives, colorings, Endocrine Disruptors and Allergens, and chemicals of concern was created. Results: eyeshadows and blushes, foundations, and lipsticks contained the most additives and endocrine disruptors, followed by eyelid pencil and liquid foundation, nail polishes were the least supplied. This distribution seems to be the same for colorings and additives with allergic potential were numerous mainly in powders. In these makeup products; Mineral oils, parabens, black iron oxide, mica, titanium dioxin and synthetic perfumes were successively the most present. Added to this category are dyes (carbon black, brilliant red green, etc.) and additives with allergenic potential (limonene, citral, etc.) Conclusions: The use of many of these substances is authorized within certain limits, due to their toxicity at higher concentrations. Other important aspects must be taken into account, such as the possibility of long-term effects. On the other hand, other substances can cause several acute undesirable side effects, namely contact dermatitis and allergic reactions. For these reasons, improvement in the criteria used for cosmetic formulation is necessary since many chemicals used individually or in combination are potentially dangerous.
Hematometra en paciente postmenopáusica: reporte de caso
Authors: Lucero Paola , Peñafiel Katherin , Soria Johanna , Álvarez Santiago , Cando Maila
Published: January 2024

El hematometra es una afección ginecológica poco común, pero con gran impacto en la calidad de vida de las pacientes, se caracteriza por la retención uterina de sangre menstrual que no se evacuó por el cuello uterino, debido a una obstrucción o bloqueo en el canal cervical. Es una condición que se presenta en el 6.7% de todas las mujeres, puede ser de causa congénita por tabique vaginal transverso e himen perforado o adquirida, como neoplasias de cérvix y cirugías previas del útero. El hematómetra produce una gran variedad de síntomas que afectan la calidad de vida de las mujeres, un diagnóstico temprano y manejo adecuado son esenciales para evitar complicaciones. Dentro de los síntomas comunes incluyen, amenorrea primaria o secundaria, dolor abdominal y pélvico de tipo constante, distensión abdominal, en contraste, en relación a mujeres postmenopáusicas el cuadro clínico en algunas suele ser asintomático. Los recursos imagenológicos como la ecografía transvaginal son fundamentales para el diagnóstico del hematómetra y ayudan a estimar su volumen y posible etiología. El manejo terapéutico del hematómetra depende de la causa subyacente e incluye: el uso de análogos de hormona liberadora de gonadotropina (GnRH), la dilatación cervical para drenar la sangre acumulada o en casos de que exista la sospecha de que el líquido retenido está infectado y resección de tumores o pólipos. Otras opciones de tratamiento es la biopsia que debe posponerse por dos semanas para disminuir las posibilidades de infección o perforación uterina y cirugías más invasivas como la histerectomía en casos de tratamiento definitivo, el manejo del dolor y de complicaciones asociadas también es fundamental. Con base en la evolución y forma de presentación, en este caso clínico el hematómetra es de origen postmenopáusico, la paciente presenta estenosis cervical y no se puede realizar legrado biopsia, por lo que se decide proceder con tratamiento quirúrgico, la realización de histerectomía abdominal total para obtener el resultado histopatológico definitivo. Paciente se recupera favorablemente en el postquirúrgico y es enviada con alta médica.
Reporte de un caso clínico de Loxosxelismo en una paciente embarazada
Authors: Pinto Pineda Verónica Alejandra , Bolaños Andrade Marco Andrés , Lalama Gómez Karolin Paulina
Published: January 2024

El loxoscelismo, también conocido como envenenamiento por araña reclusa, se refiere a la entidad médica causada por la picadura de la araña del género Loxosceles. En esta revisión, se emplea el término para describir tanto los síntomas locales como los sistémicos inducidos por las picaduras, si bien en el ámbito de la toxicología, es posible que se utilice para aludir exclusivamente a los síntomas sistémicos. La literatura científica relacionada con el loxoscelismo no es extensa debido a la falta de documentación de picaduras de araña confirmadas, es decir, aquellas en las que se ha logrado la identificación de la araña responsable en las proximidades. Los informes basados en series de casos más amplias que abordan pacientes con diagnóstico de loxoscelismo revelan que solo entre el 7 y el 14 por ciento de los casos presentan picaduras confirmadas.  En este contexto, se presenta el caso de una paciente de sexo femenino, de 26 años de edad, quien sufrió una picadura de araña en la región posterior del muslo derecho. Esta picadura resultó en el desarrollo de una flictena eritematosa con un halo y equimosis central, que en pocos días evolucionó hacia una complicación cutánea necrótica. Además, la paciente experimentó una reacción adversa a la antibioticoterapia administrada. El diagnóstico se fundamentó en los hallazgos clínicos y en los resultados de una biopsia de la lesión, y, finalmente, la paciente evolucionó favorablemente sin manifestar complicaciones sistémicas.
The Frequency of Fabry Disease in Hemodialysis Patients in The Western Mediterranean Region of Turkey
Authors: SERİN Elif Nazlı , ATAŞ Ünal , ÇETİNKAYA Ramazan , SARI Funda
Published: January 2024

Aims: The aim of the present study was to identify patients with chronic kidney disease of unknown etiology or of other detected etiology among those who were undergoing hemodialysis in the Western Mediterranean region and to detect the prevalence of Fabry mutation in these patients. In addition, we aimed to screen the family members of the cases with mutations in our study.

Methods: A total of 664 patients over the age of 18 who received hemodialysis treatment in 11 different hemodialysis centers in the Western Mediterranean region of Turkey were screened. Alpha-galactosidase A enzyme levels were first tested in male patients, and for patients with alpha-galactosidase A levels < 3.3 nmol/mL/h, GLA gene sequence analysis was performed. GLA gene sequence analysis was performed directly in female patients.

Results: In total 664 patients [313 (47.1%) male and 351 (52.9%) female] have been scanned. Fabry mutation was positive in eight female patients and one male patient.

Conclusion: According to the output of the research, the prevalence of Fabry disease among the patients who receive hemodialysis treatment determined 1.35%. In order to eliminate the conflicts upon whether the mutations which is effective on the etiology of Fabry disease are pseudo alleles it is required that new researches should be done, prospective scanning programs in a wider patient population and genetic consultancy and preventive medicine services should become more prevalent.
A DRAMATIC SURGICAL TECHNIQUE FOR A MIS (UN)DIAGNOSED BREAST CANCER: TOILET MASTECTOMY
Authors: KALAYCI Tolga , YENİ Mustafa , KARTAL Murat , FAKİRULLAHOĞLU Mesud , KARA Salih
Published: January 2024

Treatment options in metastatic breast cancer are limited, and the general approach is treatment with systemic chemotherapy. However, today, the survival of patients with advanced-stage breast cancer can be extended with targeted therapies. Surgical treatment of the primary tumour called toilet mastectomy is inevitable in cases of bleeding, infection, and advanced breast cancer with skin involvement. This case report is aimed to present the diagnosis and treatment process of a patient with advanced breast cancer who underwent toilet mastectomy.
HASHIMOTO TİROİDİTİ YÖNETİMİNDE GLUTENSİZ BESLENMENİN YERİ
Authors: KALAYCI Zeynep , KAMARLI ALTUN Hülya
Published: January 2024

Otoimmün tiroid hastalıkları, kadınlar ağırlıklı olmak üzere, nüfusun %2-5’ini etkilemektedir. Sırasıyla hipotiroidi ve hipertiroidiye yol açan, Hashimoto tiroiditi ve Graves hastalığı, en yaygın görülen otoimmün tiroid hastalıklarıdır. Hashimoto tiroiditi, foliküler hücrelerin lenfositik infiltrat ve fibrozis ile yer değiştirmesinden kaynaklanmaktadır ve tiroid antikorlarından özellikle tiroid peroksidaz antikorları, tiroglobulin antikorları ve azalmış tiroid bezi ekojenitesi ile karakterizedir. Tiroid parankimasının sürekli yıkımı, hipotiroidizme neden olur ve levotiroksin gibi sentetik tiroid hormonları kronik tedavide yaygın olarak kullanılır. Son yıllarda Hashimoto tiroiditinde gluten tüketiminden kaçınmak, popüler bir eğilim haline gelmiştir. Glutensiz diyetin ana ilkesi, içerisinde gluten bulunan buğday, arpa, çavdar, yulaf ve bunları içeren bütün yiyecek, içecek, ilaç ve besin takviyelerinin diyetten çıkarılmasıdır. Ancak glutensiz diyet aslında bir ince bağırsak enteropatisi olan çölyak hastalığı için mevcut bir tedavi şeklidir. Ayrıca gluten eliminasyonundan sonra hastalar, selenyum, iyot, magnezyum, çinko ve bakır eksikliği açısından risk altında olmaktadır. Bunun yanında glutensiz diyetler, sürdürülmesi zor ve pahalı diyetlerdir. Yapılan çalışmalarda glutensiz diyetin, Hashimoto tiroiditi gibi otoimmün tiroid hastalıklarının progresyonu ve potansiyel komplikasyonları açısından fayda sağlayabileceği bildirilmektedir. Hashimoto tiroiditi hastaları değerlendirilirken, mutlaka eşlik eden çölyak hastalığının varlığı da sorgulanmalıdır. Glutensiz diyetin Hashimoto tiroiditi hastalığının yönetiminde kullanılmasına dair yapılan çalışmalar yetersizdir ve glutensiz diyetin Hashimoto tiroiditi olan hastalara önerilmesi için yeterli kanıt bulunmamaktadır. Bu çalışmada, otoimmün tiroid hastalıklarından Hashimoto tiroiditinin yönetiminde glutensiz diyet uygulamaları ile ilgili yapılan çalışmaları derlemek, bilimsel açıdan değerlendirmek ve literatüre yeni bilgiler kazandırmak amaçlanmıştır.
Lisansüstü Eğitimde Üniversite Tercihi Hangi Faktörlerden Etkilenir?
Authors: SEVİM Ekrem , ZEYBEK Dolunay Özlem , ZEYBEK Mustafa
Published: January 2024

Yükseköğretim kurumlarında yürütülen yüksek lisans, doktora ve sanatta yeterlilik faaliyetleri lisansüstü eğitim kapsamındadır. Türkiye’de 2021 yılı itibariyle 26.963 lisansüstü eğitim programı bulunmaktadır. Bu programlarda eğitim gören yarım milyona yakın lisansüstü öğrencisi vardır. Ülkemizde birçok farklı alanda lisansüstü eğitimi verilmekle beraber sağlık yönetimi bu alanlardan yalnızca biridir. 2018 yılı itibariyle 47 yüksek lisans ve 16 doktora programı ile bu alanda lisansüstü eğitim devam etmektedir. Lisansüstü eğitimde alternatiflerin zamanla birlikte çoğalması eğitim almak isteyen bireylerin karar vermesini zorlaştırmaktadır. Bu kapsamda çalışmada sağlık yönetimi programında yüksek lisans eğitimi alan öğrencilerin tercihlerini etkileyen faktörlerin AHP yöntemiyle belirlenmesi amaçlanmıştır. Çalışmada öncelikle yapılan literatür taraması sonucunda taslak form belirlenerek uzman gruba gönderilmiştir. Alınan dönüşler çerçevesinde lisansüstü eğitimde üniversite tercihini etkileyen faktörlerin belirlenmesi amacıyla 4 ana faktör (akademik iklim, akademik süreç, fiziki ortam, üniversitenin ve şehrin marka değeri) ve 23 alt faktörden oluşan nihai form elde edilmiştir. Sağlık Yönetimi yüksek lisans programına kayıt yaptıran ve araştırmaya katılmayı kabul eden 34 yüksek lisans öğrencisiyle yüz yüze görüşme yöntemiyle uygulanmıştır. “Super Decisions” programı üzerinde AHP modeli kurgulanmıştır. Çalışma sonuçlarına göre sağlık yönetimi bölümü lisansüstü öğrencilerinin üniversite tercihini etkileyen en önemli kriterin “akademik iklim”, diğerlerine göre daha önemsiz kriterin ise “fiziksel çevre” olduğu görülmüştür. Alt kriterler arasında ise “üniversitenin marka imajı” en önemli olmuştur. Çalışma yüksek lisans öğrencilerinin lisansüstü eğitimde üniversite seçimini etkileyen faktörlerin belirlenmesi ve üniversitelere yol göstermesi açısından önemlidir.