bluuebunny/crossref_metadata_2025 huggingface dataset:
SYNTHESIS, IN SILICO STUDIES AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF 4-SUBSTITUTED BENZYLIDENE-2-(PHENOXYMETHYL) OXAZOL-5(4H)-ONES
Authors: SHAHEEN BEGUM  , ARIFA BEGUM SK  , MANEESHA M  , OME SHANTHI T  , SATYA VARALAKSHMI D  , MANJUSHA RK  , BHARATHI K  , BHARATHI K
Published: October 2019

Objective: Arylidene-1, 3-oxazol-5-ones represent potential antibacterial agents. In the present work, a series of 4-substituted benzylidene-2- (phenoxymethyl) oxazol-5(4H)-ones were synthesized and screened for antibacterial activity against Gram-negative bacteria Escherichia coli. To explore plausible mechanisms, synthesized compounds were docked with DNA-Gyrase enzyme.

Methods: All the reactants, phenoxy acetyl chloride, acetic anhydride, sodium acetate, substituted aromatic aldehydes, and glycine were triturated in a mortar by mechanical stirring. The antibacterial potentiality of the compounds was screened against E. coli using the disk diffusion method and the activity was recorded as a zone of inhibition.

Results: Compound 2d, possessing 3, 4, 5-trimethoxy functionality on benzylidene ring exhibited the highest activity with 19 mm of the zone of inhibition which might be due to its higher interactions with DNA-Gyrase enzyme (ΔG-8.41 kcal/mol). Compounds 2a, 2b, and 2c exhibited moderate activity in the antimicrobial assay as well as in docking study indicating the positive contribution of substitution on benzylidene ring.

Conclusion: A series of 4-substituted benzylidene-2-(phenoxymethyl) oxazol-5(4H)-ones were synthesized and evaluated for antibacterial activity. Compounds 2a, 2b, and 2c displayed moderate activity whereas 2d showed maximum zone of inhibition (19 mm). The good activity of these derivatives presumed to be due to the conformational flexibility of phenoxy methylene moiety which can be well accommodated in the target binding site.
CYTOTOXICITY AND EXPRESSION STUDIES OF ANGIOGENESIS-PROMOTING GENES IN CANCER CELL LINES UNDER THE TREATMENT OF CANCER CANDIDATE DRUGS
Authors: SALAM ABBAS  , SUDHAKAR MALLA
Published: October 2019

Objective: Human antigen R (HuR) is a member of the RNA-binding proteins which is a critical factor in mediating the proangiogenic factors resulting in angiogenesis among the tumors. During inflammation and anoxic conditions, cytokine interleukin-1 (IL-1) was found to activate the HuR which, in turn, aids in upregulation or downregulation of the hypoxia-inducible factors (HIF) 1α. The present study was designed to study the correlative effect of the cancer drug docetaxel (Taxotere) on the expression levels of HuR and HIF1α using HeLa cell lines.

Materials and Methods: The drug was tested for cytotoxicity among the cancer cell lines using the lactate dehydrogenase and 3-(4)5-Dimethyl-thiazol-zyl)-2, 5, biphenyl tetrazolium bromide assay. Gene expression and correlation were found by the real-time expression of the gene members under the treatment. The same study was also confirmed using the molecular docking tools to screen for the possible potential anticancer target.

Results: The drug was found to decrease the expression levels of the cytokine IL-1 along with the HuR proteins. This was also found to show a positive inhibition on the expression of HIF1α. The study was also confirmed using the molecular docking studies which are in accordance to the wet lab studies.

Conclusion: The present study confirmed that the two receptors might act as potential anticancer drug targets which might aid in designing more novel drugs.
FORMULATION AND CHARACTERIZATION OF FLOATING BEADS OF ANTIBIOTIC BY EMULSION GELATION TECHNIQUE
Authors: KHALIFA MY  , SHAIKH SIRAJ N
Published: October 2019

Objective: The study aims at formulation and characterization of floating hydrogel beads of cefdinir for improving its bioavailability.

Methods: Cefdinir is broad-spectrum, oral, third-generation cephalosporin antimicrobial agent active against Gram-positive and Gram-negative bacteria. The floating hydrogel beads of cefdinir were formulated with polymers such as sodium alginate and sodium carboxymethyl cellulose by emulsion gelation technique using olive oil/castor oil. The beads were evaluated for surface morphology, bead size, entrapment efficiency, floating characteristics, in vitro swelling, in vitro drug release, and stability studies.

Results: On the basis of evaluation, all the beads show good swelling up to 12 h in 0.1 N hydrochloric acid. The swelling was followed by values in order of vegetable oil > mineral oil in case of emulsion gelation method. Scanning electron microscopy study shows that beads were spherical in shape. Comparing all the formulations, formulation FB12 was considered as optimized formulation which shows % yield 94.06±0.11, % floating 87.28±0.90, in vitro drug release 94.68, and also stable in stability studies.

Conclusion: From the findings, it may be concluded that cefdinir-loaded floating beads were successfully prepared and proved to be useful for the better bioavailability and patient compliance for enhanced antimicrobial activity.
A POTENT CYTOTOXICITY AND ANTIMICROBIAL ACTIVITY OF ZINC OXIDE NANOPARTICLES SYNTHESIZED BY LEAF OF IPOMOEA PES-CAPRAE (L.) R. BR.
Authors: RAMESH A  , SUNDARRAJ P  , BALAMANI J
Published: October 2019

Objective: The present study was conducted to investigate the cytotoxicity and antimicrobial activity of zinc oxide nanoparticles (ZnO NPs) synthesized as eco-friendly technique from the leaf extract of Ipomoea pes-caprae (L.) R. Br. against human lung adenocarcinoma (A549), brain tumor (U87) cells, and human pathogens Salmonella typhi, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa, and Bacillus subtilis.

Materials and Methods: The work was carried out with varying precursor (plant extract) volume to optimize the synthesis of ZnO NPs and it was confirmed by ultraviolet (UV)-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) analysis, scanning electron microscopy, and atomic force microscope (AFM) characterization techniques and evaluate its cytotoxicity activity by 3-(4,5-dimethyl-2- thiazolyl)-2,5-diphenyl--tetrazolium bromide assay method, antimicrobial activity by disk diffusion method.

Results: A peak at 320 nm with maximum intensity was observed at temperature of 80°C with pH of 8.0 in UV-visible spectroscopy confirmed the formation of ZnO NPs and we calculate the size of ZnO NPs from XRD data found as 15.8 nm. The FTIR analysis evaluated that the presence of different functional groups is carboxyl, amine, and phenolic compounds of leaves extract which are involved in the reduction of zinc ions and acts as capping the ZnO NPs. AFM microgram confirms that ZnO NPs were in nanorange and spherical in nature. The cytotoxicity activity of A549 and U87 cell lines treated with various concentrations of ZnO NPs showed a dose-dependent increase in cell inhibition and the half maximal inhibitory concentration value was calculated to be 7.8 μg/ml. The antibacterial activity of selected pathogens shows higher zone of inhibition.

Conclusion: The present study reveals that synthesized ZnO NPs capping with various bioactive compounds present in the leaf of I. pes-caprae show promising activity of cancer cell lines and antimicrobial agents; hence, further detailed study may lead to develop at a novel phytomedicine for the anticancer and antimicrobial drugs.
FORMULATION AND INVESTIGATION OF POLYMERIC MULTIPLE UNIT PELLET SYSTEMS CONSISTING OF SUSTAINED RELEASE GLIMEPIRIDE AND IMMEDIATE RELEASE ATORVASTATIN CALCIUM
Authors: BHARAT BIJAPUR  , GOWDA DV  , VISHAL GUPTA N  , SHAILESH THIRUMALESHWAR  , PRAVEEN SIVADASU  , MANJUNATH M
Published: October 2019

Objective: The objective of the present work was to develop novel fixed-dose combinations (FDCs) for improvement of glucose tolerance in type II diabetes mellitus patients associated with dyslipidemia.

Methods: Multiple unit pellet systems (MUPSs) consisting of sustained release (SR) glimepiride and immediate release atorvastatin calcium pellets were formulated. The SR glimepiride pellets were prepared using a combination of locust bean gum and gum ghatti/guar gum. Similarly, the immediate release of atorvastatin calcium pellets was prepared using locust bean gum suspension as a binder.

Results: The formulated pellets were characterized using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC). Further, surface morphology of the formulated pellets was done by scanning electron microscopy (SEM). FT-IR and DSC studies suggested that there were no chemical interactions between the drug and natural polymers. SEM studies revealed that formulated pellets were in spherical shape. Based on in vitro evaluation, the SR glimepiride formulation developed using a combination of 2% locust bean gum and 2.5% gum ghatti polymers sustained the release of the drug up to 12 h. Similarly, the immediate release atorvastatin calcium formulation containing 1% w/w locust bean gum suspension as a binder and 7% croscarmellose sodium showed fast disintegration of pellets. The in vivo studies in albino Wistar rat revealed that there was an improvement in bioavailability of the drugs. Stability studies showed that there were no significant changes in the drug content and physical appearance of the prepared SR glimepiride and immediate release atorvastatin pellet formulations.

Conclusion: Thus, the formulated FDC as MUPS can be used as an alternative approach for treating diabetes mellitus-induced dyslipidemia.
The ORMULATION OF GLIMEPIRIDE AND ATORVASTATIN CALCIUM NANOPARTICLES BY 1 LIQUID ANTISOLVENT PRECIPITATION METHOD THROUGH DOUBLE STEP COMMINUTION 2 TECHNIQUE AND ITS EVALUATION
Authors: VISHAL S REDDY  , GOWDA DV  , VISHAL GUPTA N
Published: October 2019

Objective: The present research is to formulate Glimepiride and Atorvastatin Calcium Nanoparticles for the type-2 diabetes mellitus for improvement of glucose tolerance associated with dyslipidemia formulated by liquid antisolvent precipitation technique.

Method: Glimepiride nanoparticles and atorvastatin calcium nanoparticles were prepared by using a liquid antisolvent precipitation technique. Solvent to antisolvent ratio used was 3.5:6.5 and 2.5:7.5 and the drug concentration used was 40 mg/ml and 60mg/ml respectively.

Result: The XRD was determined, the data of the optimized Glimepiride formulation revealed that the prepared nanosized Glimepiride powder was existed in crystalline form. The percent yield for the formulations of Glimepiride and atorvastatin calcium nanoparticles was found to be 72.8±1.8%, 75.3±2.2% respectively. In-vivo studies in albino wistar rats demonstrated that the Cmax and AUC0−24h of optimized Glimepiride and atorvastatin calcium  nanosized formulation was found to be 24451.14±2170.5 ng/ml, 162945.12±241.5 ng/ml and 1385.43±153.3 ng/ml,3636.57±65.2 ng/ml respectively. Dissolution study of optimized formulations shows that marked enhancement of dissolution rate. The stability studies of mixture of Glimepiride and atorvastatin calcium powder when stored at 4±3oC refrigerated temperature has shown no significant changes in physical appearance, drug content, particle size and PDI. Conversely the sample stored at room temperature has shown significant increase in particle size and PDI, with no significant changes in drug content and physical appearance.

Conclusion: The Formulation of glimepiride and atorvastatin calcium drug nanoparticles shows increase in the surface-to-volume ratio of API, resulting in better drug solubility and hence increasing the bio-availability when compared to its pure form.
PHYTOCHEMICAL AND PHYSICOCHEMICAL ANALYSIS OF MICROWAVE-ASSISTED EXTRACTION CORIANDRUM SATIVUM L. LEAVES AND ITS BIOLOGICAL EVALUATION
Authors: SAMREEN FATEMA  , MAZAHAR FAROOQUI  , PATHAN MOHD ARIF  , SYED UMMUL KHAIR ASEMA
Published: October 2019

Objective: The main objective of the present work is to carry out the phytochemical constituent present and physicochemical analysis of microwave-assisted extract (MAE) of Coriandrum sativum leaves and to investigate its antibacterial activity.

Methods: The powdered samples of the leaves were extracted and analyzed for physicochemical properties. Extraction was carried out for C. sativum using different solvents and used for phytochemical investigation. Infrared (IR) spectrum and antibacterial activity of MAE were carried out.

Results: The results show that the percentage extract is different in the different solvents and also differs in phytochemical constituents. Phytochemicals present in the MAE also confirmed by IR spectroscopy. MAE is active against bacteria.

Conclusion: The phytochemicals present in C. sativum is confirmed by IR spectrum and these phytochemicals responsible for antibacterial activity.
IN SILICO DOCKING ANALYSIS OF YOHIMBINE ALKALOIDS FROM CATHARANTHUS ROSEUS AGAINST DENGUE FEVER
Authors: GIRIJA R  , ARUNA S  , SANGEETHA R
Published: October 2019

Objective: In this docking study was performed by the active site of NS2B-NS3 protease with selected plant alkaloids derived from Catharanthus roseus. On the basis of docking results, out of the nine alkaloids yohimbine might be considered as the best inhibitors of NS2B-NS3 protease protein.

Methods: Lipinski rule was employed to check the ligand likeliness of the compound. The three-dimensional crystallographic structure of NS2B-NS3 protease (ID.2FOM) fetched from the protein data bank. The in silico docking studies were performed by “AutoDock version 4.2” software tool.

Results: Yohimbine is having the best binding score (−7.18 Kcal/mol) than the other eight compounds.

Conclusion: Hence, it has been concluded yohimbine as a novel inhibitor for NS2B-NS3 protease in dengue fever.
A VALIDATED STABILITY-INDICATING REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DACLATASVIR, IDENTIFICATION AND CHARACTERIZATION OF DEGRADATION PRODUCTS USING LC-ESI-QTOF-MS
Authors: SNEHAL V WARGHADE  , KAILAS G BOTHARA
Published: October 2019

Objective: The objective of this study was to report the stability of antiviral drug, daclatasvir (DCV) based on the information obtained from forced degradation studies and characterization of degradation products (DPs) by tandem mass spectrometry (MS/MS) analysis.

Methods: Chromatographic separation was achieved on Shimadzu liquid chromatography (LC) 20 AD high-performance LC system with photodiode array detector having Kromasil C18 (250 mm×4.6 mm×5 μm) with isocratic elution of a mobile phase composed of ammonium acetate buffer (pH 4.5) and acetonitrile in a ratio of 50:50 at 315 nm. The drug was subjected to forced hydrolytic, oxidative, photolytic, and thermal stress in accordance with the ICH guideline Q1A (R2). The drug showed degradation under acidic and basic hydrolytic conditions by forming two DPs. The DPs were characterized using LC– MS/MS studies and the pathways of fragmentation are proposed. Validation of the developed method was carried out in accordance with ICH guidelines.

Results: Two DPs were identified, DP-1 as (S)-1-((S)-2-(5-(4’-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-aminium and DP-2 as (S)-2-(5-(4’-(2-((S)-1-((S)-2- ((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-ium.

Conclusion: The method proved to be simple, accurate, precise, specific, robust, and less time consuming and can be applied for the determination of DCV in bulk and marketed formulation.
Elsayed A Usage and Knowledge of the Over- the- Counter Medicines Among Patient Visiting Ophthalmic Hospital in Wad Medani, Sudan
Authors: Elsayed Amani Mirghani
Published: October 2019

Objective

The aim of this work is to determine the usage pattern and knowledge of OTC medicines among Sudanese attending Ophthalmic hospital in Wad-Medani/Sudan.

Methods

It is a cross-sectional study in which 500 patients were surveyed.

Results

Participants had taken OTC medicines to treat headache, pain, allergy, heart pain, etc. General knowledge of participants is poor. Majority of respondents admitted having no knowledge about the active ingredient, the maximum dose or side effects of paracetamol. One-third of respondents had taken a dose lower or higher than the recommended one. The main reason of taking larger dose was the intensive pain. More than a half (59.0%) of respondent reported using more than one OTC medications when they had multiple symptoms. The results showed that knowledge is associated with the level of education. Regarding the sources of information, two third of respondents (68.8) get information about the non-prescription medicine from the pharmacist. Only 10.4% read information about the OTC medicines from the leaflet in the package.

Conclusions

In Sudan, pharmacists play major role in OTC medication safety as the illiteracy comprises high percentage.
Estados Unidos frente a las conspiraciones fraguadas en su territorio por exiliados de la época de la Revolución. El caso huertista frente al villista, 1914-1915
Authors: LERNER VICTORIA
Published: October 2019

THE PURPOSE OF THIS ARTICLE IS TO ANALYSE THE ATTITUDES OF THE U.S. GOVERNMENT TOWARDS THE CONSPIRACIES ORGANIZED IN ITS TERRITORY, BY MAXICAN EXILES AND REBELS DURING THE CLIMATIC YEARS 1914-1915. I POINT OUT THE DIFFERENT MEANS (JUDICIAL, FINANCIAL, DIPLOMATIC, POLITIC,ETC) HE USED TO INTERFERE: PROOVING THAT IN ORDER TO PROSPER THESE ACTIVITIES NEED UNITED STATES SUPPORT OR AT LEAST HIS CONCEALED ACCEPTANCE. WITH THIS SCOPE IN MIND. I DISCUSS THE FAILURE OF THE HUERTISTA´S REBELLION IN SPRING 1915, AND THE SUCCES OF DIFFERENT ACTIONS DIPLOMATIC. ALLOCATION OF RESOURCES, SPYING, MILITARY CONSPIRACIES---OF THE VILLISTAS--- REBELS BETWEEN 1914 AND AUGUST 1915. I USE DIFFERENT SOURCES TO DEVELOP THESE TWO CASES: EXILES´S AND UNITED STATES GOBEREMENT.
Significación e historia: el problema del limite en el documento histórico
Authors: BETANCOURT MARTÍNEZ FERNANDO
Published: October 2019

EL PRESENTE ENSAYO ANALIZA EL ESTATUTO DE LA FUENTE HISTÓRICA COMO PARTE DEL SISTEMA DE MEDIACIONES DE LENGUAJE AL QUE RECURRE EL HISTORIADOR EN LA PRACTICA DE SU OFICIO. EL AUTOR DISCUTE DE QUE MANERA LA FUENTE, ANTES QUE UNA FORMA NEUTRA DE ACCESO A LA REALIDAD DEL PASADO, ES UNA PRODUCCIÓN CULTURAL SOMETIDA A SISTEMAS DE SIGNIFICACIÓN QUE SON LOS QUE PERMITEN SU LECTURA E INTERPRETACIÓN. PARA ELLO, ACUDE AL ESTUDIO DE UNA FUENTE DE FINALES DEL SIGLO XVIII, EL DIARIO ESCRITO POR JOSÉ GÓMEZ, QUE PRESENTA UNA VISIÓN COTIDIANA DE LA CIUDAD DE MÉXICO BAJO EL GOBIERNO DEL CONDE DE REVILLAGIGEDO. LAS PREGUNTAS QUE GUÍAN EL TRABAJO SON, PRIMERO ¿COMO SE PRODUCE LA FUENTE HISTÓRICA?, Y SEGUNDO, ¿COMO SE LEE?
Filosofía y pensamiento crítico latinoamericano de la actualidad
Authors: Magallón Anaya Mario
Published: October 2019

La filosofía y el pensamiento crítico desde nuestra América han incorporado a nuestro filosofar, conceptos y categorías filosóficas provenientes de muy variadas tradiciones, algunas veces opuestas y otras contradictorias, tanto de las naciones de la región latinoamericana y caribeña, como del resto del mundo, especialmente del Occidente europeo. Sin embargo, esta diversidad de ideas de múltiple origen constituyen, hasta la actualidad, el instrumento del pensar filosófico-crítico sobre la realidad sociohistórica latinoamericana y caribeña; lo cual de ningún modo puede resultar sospechoso y extraño en el marco del pensamiento latinoamericano actual, como lo creen algunos filósofos sudamericanos y mexicanos.
La querella intelectual del quechuaymara Fausto Reinaga contra Fernando Diez de Medina
Authors: Ticona Alejo Esteban
Published: October 2019

El quechuaymara boliviano Fausto Reinaga tuvo en su vida intelectual varios debates y polémicas. Su disputa con el escritor Fernando Diez de Medina, posiblemente sea el más conocido y difundido. Reinaga escribió un libro en 1964 bajo el título de El indio y el cholaje boliviano. Proceso a Fernando Diez de Medina , motivo de este breve artículo. Esta obra está situada en su etapa de pensador marxista, aunque su contenido adquiere “la voz y el pensamiento indio” contra el escritor mestizo boliviano Diez de Medina.
Technical eguipment in the construction: problems and ways to improve
Authors: Tuskaeva Zalina Ruslanovna
Published: October 2019

Construction equipment is one of the most significant factors contributing to the decrease in the cost of the work, increase of the profitability of the industry as a whole. In the process of reforming of the Russian economy in general and the construction complex in particular, technical equipment of building production has fallen sharply both in quantitative and qualitative sense. Vehicles with expired service life have a sharp drop in performance. Burden on many kinds of construction machinery have increased. There is a growing need for repair and renovation of the construction equipment fleet. There is a relatively high proportion of the massive equipment where the need for it is low. This is accompanied by higher costs for small-scale works. Serious problems were also detected in the sphere of construction equipment repair. This market is divided into two categories: very expensive services with spare parts, and relatively inexpensive, but not enough qualified services with a corresponding guarantee of reliability. In the context of the difficult financial situation of building units it is becoming a significant problem. Major concerns arise on how to optimize the technical and economic indicators of operation of the machines due to the increase in the cost of purchased equipment and operating costs for its maintenance. The analysis of the use of construction machinery shows that a solution to the problems existing in this specific part of the construction activities is required. The time has come when it is necessary to develop and implement the strategy development and effective use of technical equipment in the construction. The paper outlines the key issues and suggests the approaches to improve the technical equipment in the construction.
Compression test of cold-formedsteel perforated profile with steel sheathing
Authors: Shamanin Aleksandr Yur’evich
Published: October 2019

The subject of this paper is the stability and strength of cold-formed and perforated steel sigma-section columns with steel sheathing of different thickness. Ceilings with and without steel sheathing of different thickness are tested to failure in compression on a laboratory machine, which was based on a manual hydraulic jack. Series of 4 experiments with full-scale walls (2.5 m height) were carried out. Also, for examination of the role of boundary conditions, the sheet in a ceiling is either left free or connected to base with screws.In civil engineering there are many experiments and methodologies for calculating the strength and buckling of ceiling with the sheathing of various materials, such as oriented strand board and gypsum board. However, for producing superstructures of ships the materials with high plastic properties and strength characteristics are required. For example steel possesses such properties. It was the main reason for conducting a series of experiments and studying the behavior of cold-formed steel columns with steel sheathing. During the experiments the deformation of the cross-section of three equally spaced cross sections was determined, as well as the axial deformation of the central column in the ceiling with steel sheathing.The test results showed the influence of the thickness of sheathing and boundary condition of a sheet on the strength and buckling of ceiling. According to the results of the tests it is necessary to evaluate the impact of the sheathing made of different materials and if necessary to carry out further tests.
RESULTS OF COMPRESSION TESTING ON PSEUDO-COHESIVE SOIL
Authors: Ofrikhter Vadim Grigor’evich , Ofrikhter Yan Vadimovich
Published: October 2019

Natural non-treated sand reinforced with randomly oriented short polypropylene fibers of 12 mm in length was tested to determine creep characteristics. This study is a part of the research aimed at encouraging fibrosand (FRS) application in subsoils, embankments and retaining wall constructions. Fiber content was accounted for 0.93 %. Twin specimens were put to creep tests (1-D compression) using the two curve method. The test results were analyzed and checked with the use of ageing, hardening and hereditary creep theories. On the basis of approximation of the test results the creep deformation equation at constant stress for tested fibrosand was obtained. The assessment of fibrosand secondary compression was carried out by the FORE method. As a result, the value of the void ratio by the end of the secondary compression had been eu=0.7041. For determination of the beginning of the secondary compression the rate equation was superimposed on the empirical curve. The point of the graph divergence is the beginning of the secondary compression process. The secondary compression had begun by the time moment being equal to 9360 min. The void ratio by the beginning of the secondary compression had amounted to 0.70574. Fibrosand is a specific type of improved soil relating to so-called pseudo-cohesive soil. This type of soil is characterized by cohesion like cohesive soils, but, at the same time, by the filtration coefficient of about 1 m per day like non-cohesive soils. Pseudo-cohesive soil testing helps to understand the distinctive features of the stress-strain state of this kind of materials. Municipal solid waste also relates to them.
INTERACTION OF A LONG PILE OF FINITE STIFFNESS WITH SURROUNDING SOIL AND FOUNDATION CAP
Authors: Ter-Martirosyan Armen Zavenovich , Ter-Martirosyan Zaven Grigor’evich , Trinh Tuan Viet
Published: October 2019

The article presents the formulation and analytical solution to a quantification of stress strain state of a two-layer soil cylinder enclosing a long pile, interacting with the cap. The solution of the problem is considered for two cases: with and without account for the settlement of the heel and the underlying soil. In the first case, the article is offering equations for determining the stresses of pile’s body and the surrounding soil according to their hardness and the ratio of radiuses of the pile and the surrounding soil cylinder, as well as formulating for determining equivalent deformation modulus of the system “cap-pile-surrounding soil” (the system). Assessing the carrying capacity of the soil under pile’s heel is of great necessity. In the second case, the article is solving a second-order differential equation. We gave the formulas for determining the stresses of the pile at its top and heel, as well as the variation of stresses along the pile’s body. The article is also formulating for determining the settlement of the foundation cap and equivalent deformation modulus of the system. It is shown that, pushing the pile into underlying layer results in the reducing of equivalent modulus of the system.
Constantly operating geoinformation system for geoenvironment as a tool for pre-project investigations in city infrastructure development (on the example of moscow)
Authors: Osipov Viktor Ivanovich , Mironov Oleg Konstantinovich , Belyaev Valeriy L’vovich
Published: October 2019

The concept of a geoinformation system for urban geoenvironment is concerned. Geological data is necessary for the sustainable development of city infrastructure. The municipal departments should use geological and environmental information for perspective planning, selecting the location for important infrastructure objects, solving ecologycal problems, and in decision making. The concept includes a preliminary list of system’s users, their informational needs, main functionalities, methodical approaches to the system design and development. Geological data must contain source documents from geological archives “as is” and geodata based on its interpretation for various tasks. These data must be checked carefully and updated with new engineering-geological investigations. Geoinformation system must integrate various geological, engineering-geological, hydrogeological, and environmental data. Sophisticated procedures must be provided to check complicated logical dependences in the system database and to analyze contradictions between source documents. 3D modeling is an adequate language for presenting geological data, therefore, the considered system must include 3D models of various scales. In the suggested concept 3D modeling is considered as a tool for investigations, not only for presentations. The end users should have possibilities to get results of their queries in various formats: tables, geological and thematic maps, geological cross-sections, 2D and 3D grids as source data for mathematical modeling, etc. In conclusion, the paper briefly describes IEG RAS activities in GIS technologies for geological cartography and 3D modeling.
AUTOCAD IN THE OPERATIONAL MANAGEMENT OF THE CONSTRUCTION SITE
Authors: Tsareva Marina Vladimirovna
Published: October 2019

Operational management of the construction is usually based on information analysis systems, which are aimed at the monitoring of working schedule and volumes as consistent with predicated schedules. The result of such systems’ operation is traditional information graphics (diagrams, charts, etc.), which provides idea on the current state of the construction site and deviations from the planned settings. The author considers the visualization technology of construction of objects using an image of the situation on the AutoCAD drawings, converted into an interactive format. The article focuses on imperfections of the existing technologies of information support of the managers. The creation of unified IT platform is offered on the basis of CAD for creating an integrated information storage and visualization of the environment using electronic drawings and diagrams. Using interactive methods it is possible to illustrate the condition of almost any part of the construction project using these drawings and diagrams. E-drawings contain the basic information resources - estimates, plans, sections, specifications, technology, construction, etc. necessary for the calculation of indicators. The author proved that implementation of visualization is most efficient in case of electronic drawings in 3D format.
SYNTHESIS OF STRUCTURES OF CELLULAR-CONCRETE COMPOSITES WITH NANOSIZED COMPONENTS
Authors: Solonina Valentina Anatol'yevna , Zimakova Galina Alexandrovna , Baianov Dmitriy Sergeevich , Sharko Pavel Valer'evich , Zelig Marina Petrovna
Published: October 2019

The article reveals the results of one of the stages of the integrated research studying the influence of compounds and disperse characteristics of silica-containing materials on structure formation and qualities of cellular concrete. It has been indicated that the improvement of physical and mechanical properties of cellular concrete can be achieved through creating the best possible pore structure of the concrete and the structure of interporous frame as well as intensification of hydration and crystallization processes under hydrothermal treatment and, as a result, the increase in number and perfecting morphology of hydrated phases. Up-to-date knowledge about the structure and properties of cellular concrete shows potential capacities to enlarge strength characteristics through forming a nanopore structure of a matrix stone, the effective usage of power potential of multicomponent binding including Portland cement, high-calcium lime, activate silica components with grains of submicron and nanometer range.
Violencia de pareja en personas con disforia de género
Authors: Fernández María , Guerra Patricia , Concha Verónica , Neir María , Martínez Noelia
Published: October 2019

El primer objetivo de la investigación fue conocer y evaluar los tipos de violencia de pareja en un grupo de 48 personas con disforia de género y; en segundo lugar, establecer diferencias en función de la identidad. Se utilizó una adaptación de la encuesta elaborada por Díaz y Núñez (2015). El mayor porcentaje de violencia experimentada se dio en violencia psicológica, seguida de la sexual y física y por último y en menor medida, la económica. Según su identidad, sufrieron más violencia física, económica, sexual y psicológica las personas con identidad femenina. En la mayor parte de las personas con identidad femenina que pidió ayuda la violencia se mantuvo o aumentó, mientras que en aquellas con identidad masculina cesó o se mantuvo. Las personas con identidad femenina sufren más violencia de pareja en todas sus formas. Las consecuencias de pedir ayuda exterior también son más negativas para éstas.
Elaboración de una escala de participación en actividades extracurriculares para niños
Authors: Fernandes Matias Neyfsom Carlos
Published: October 2019

El artículo presenta el proceso de elaboración de la escala de participación en actividades extracurriculares para niños (EPAEN). La primera versión del instrumento fue aplicada a 178 estudiantes de ambos sexos de dos escuelas públicas de una ciudad de Minas Gerais (Brasil),de 8 a 12 años de edad, que cursing al 4º, 5º y 6º año de la escuela primaria. Además de las propiedades psicométricas de la prueba se investigaron las diferencias relativas a la escuela, al año escolar, al sexo y participación en actividades extracurriculares estructuradas y no estructuradas. La EPAEN presentó índices psicométricos adecuados con índice Kaiser-Meyer-Olkinigual a 0,64 y prueba de esfericidad de Bartlettsignificativa. El análisis factorial apuntó la presencia de tres factores. Se identificaron diferencias (p<0.050), en la comparación por sexo, en el primer y tercer factores. Los niños juegan más que las niñas, mientras que se involucran más con actividades académicas/responsables. La escala es útil en el análisis de la participación de niños en actividades extracurriculares.
Social and Emotional Loneliness Scale for Adults: evidencias psicométricas en el noreste de Brasil
Authors: Guimarães Amorim Luize Anny , Nunes da Fonsêca Patrícia , Marcolino Alves Machado Gabriela , Cardoso Guimarães Clara Lohana , Nascimento da Silva Paulo Gregório
Published: October 2019

Este artículo analiza una investigación-intervención realizada con un grupo de apoyo a la adopción en la ciudad de Canoas, Rio Grande do Sul, Brasil. Con ese fin, articula los datos de la investigación con el concepto de grupo-dispositivo, para comprender cómo el concepto puede contribuir como una herramienta de intervención para el campo de la psicología en el apoyo de la adopción. Dieciocho miembros del Grupo de Apoyo a la Adopción, en diferentes fases del proyecto adoptivo, participaron en el estudio. Los datos se analizaron a través del Análisis del discurso desde una perspectiva foucaultiana, que comprende los discursos en una ubicación histórico-social singular. A través de los resultados fue posible mostrar cómo el grupo-dispositivo, en el campo de la adopción, desnaturaliza los significados establecidos sobre el perfil de adopción deseado, los obstáculos de la adaptación, los prejuicios involucrados en la adopción y los movimientos grupales. Al enfatizar los movimientos singulares, el concepto permite que otros sentidos sobre el cuidado, la protección y la constitución familiar sean producidos.
Un análisis sobre la percepción normativa, y su relación con los valores y el bienestar psicosocial
Authors: Saggese Luciana , Beramendi Maite
Published: October 2019

Diversos autores coinciden en que la transgresión en la Argentina es una práctica común, arraigada y naturalizada. Se propone un modelo que analiza la percepción del sistema normativo como un organismo complejo que comprende no solo las normas en sí, sino a las instituciones y agentes que intervienen en él. El objetivo del presente estudio es analizar, desde una perspectiva psicosocial, la relación entre la percepción del sistema normativo, el bienestar y los valores de trabajadores de la Ciudad Autónoma de Buenos Aires (CABA) y el Conurbano Bonaerense. Se diseñó un estudio no-experimental, descriptivo-correlacional. La muestra es intencional, compuesta por 148 trabajadores. Los análisis descriptivos indican una mala percepción del sistema normativo, priman valores asociados a la salud, la supervivencia y la estabilidad personal; y un alto nivel de bienestar psicosocial. Como hallazgo novedoso no se encontraron relaciones entre la percepción del sistema normativo y el resto de las variables.
Análisis factorial exploratorio del Inventario de Integración Familiar en una muestra de trabajadores de la ciudad de Arequipa
Authors: Arias Walter , Castro Rodolfo , Rivera Renzo , Ceballos Karla
Published: October 2019

El presente artículo describe las propiedades psicometrías del Inventario de Integración Familiar. La muestra fue de 420 personas y los participantes fueron seleccionados a través de un muestreo no probabilístico intencional. Los resultados indican que la prueba presenta 4 factores que en su conjunto explican el 55.2% de la varianza, mientras que sus índices de confiabilidad fluctúan entre ω=.867 y ω=.932. En consecuencia, el Inventario de Integración Familiar mostró tener propiedades psicométricas robustas por lo cual se ha comprobado su validez y precisión en la medición de la variable integración familiar.
Pensamiento de la Burguesía Azucarera y estigmatización del Cortero de Caña en el Norte del Cauca: Algunos elementos de análisis en el discurso de Santiago Eder y Don Hernando Caicedo
Authors: Córdoba Gómez Luis Antonio
Published: October 2019

El surgimiento y consolidación de la agroindustria azucarera colombina, asentada en el valle geográfico del río Cauca, corresponde a un proceso histórico donde intervienen diversidad de factores: sociales, geográficos, ambientales, económicos, políticos, tecnológicos y culturales. La modernización económica del sector azucarero colombiano supuso la implantación de las relaciones de producción capitalistas, lo cual introdujo drásticos cambios en las formas de explotar la mano de obra, la tierra y la producción de azúcar que se han respaldado en ideologías y formas de pensar dominantes por parte de la burguesía azucarera. En este orden de ideas aquí se destacan algunos elementos de análisis, extraídos de los discursos de Santiago Eder y don Hernando Caicedo, a partir de los cuales se hizo operante la estigmatización del cortero de caña.
La Carta de Jamaica: Inventario de un genocidio y análisis del sueño frustrado de libertad
Authors: Arboleda González Carlos
Published: October 2019

Pensamos que la Carta de Jamaica es el documento central del sueño bolivariano porque fue redactada en plenas guerras de independencia y porque preludia el futuro político de la América mestiza. Aquí demostraremos que el inventario del genocidio se ha quedado corto si sólo ha sido referido desde la Conquista y también, en segundo lugar, que el análisis político de Simón Bolívar, en 1815, posee todasu vigencia y urgencia. José Carlos Mariátegui, el gran pensador peruano, ya había escrito, al comienzo del siglo XX, que habíamos cambiado el feudalismo español por el criollo y el encomendero por el tiranuelo.La Carta de Jamaica es un documento histórico, político y literario al que damos una relevancia capital en la vida y en la obra de Simón Bolívar.

Y tiene un valor para nosotros como texto erudito, como manifiesto político que ayuda también al estudioso de la vida del libertador para entender su propia evolución política ypersonal. En este ensayo nos hemos guiado por los lineamientos expresados en la segunda parte de este escrito que tiene que ver con el inventario del genocidio y con el análisis de la posible evolución política de Indoamérica.
Vaciamiento Social: La perpetúa discriminación
Authors: Ocampo Banda Luis , Lizárraga Patrón Adolfo , Vargas Alvarado Ma. Guadalupe
Published: October 2019

El modelo socioeconómico y político dominante impone sus lógicas selectivas de integración, discriminación y segregación social. En sociedades pos-estatales el consumo desplaza, rompe los hilos vinculantes y la sociedad toda se fragmenta, se diluye, deja al descubierto la supremacía del yo individualizado por sobre el menguado yo colectivo.

En tanto, los estándares mercantiles de “normalidad”, “deseable”, “bueno”, terminan por imponerse en el imaginario de las mayorías como un deber ser.  Así, se convive dentro de estructuras sociales y de sus correspondientes subjetividades que si bien claman mayor apertura y tolerancia frente a la diferencia,  demandan a la par distanciamiento y protección de todas aquellas formas de comportamiento y organización social que les resulten ajenas, intimidantes. Discurso dual  y contradictorio que solo logra ser armonizado en la práctica consumista, momento en el cual los individuos adquieren la categoría, artificiosa,  de igualdad.
Activismo Judicial en Latinoamérica: Movimientos sociales y derecho. Una aproximación
Authors: Victoria Russi Ángelo Mauricio
Published: October 2019

Desde orillas conservadoras o progresistas, no se puede negar que en las últimas décadas el activismo judicial de los tribunales latinoamericanos en sede constitucional, ha favorecido ciertos movimientos sociales. 

Esto no obsta para desestimar los peligros que conlleva este activismo, tensión entre razón de Estado y razón jurídica, ambivalencia que provoca la actividad para caracterizar al tribunal como legislador negativo o legislador positivo, preocupación por las garantías individuales o por el proceso político democrático, la inminente función legislativa e incluso constituyente que debe asumir. A continuación esbozaremos consideraciones históricas para sustentar por qué existe un activismo judicial de corte “publicista” cuando se trata de abordar temáticas relacionadas con movimientos sociales, en el seno de los tribunales constitucionales latinoamericanos, para seguidamente apuntalar en algunos fallos de estos países, y terminar con otros de Colombia.
TO THE 100th ANNIVERSARY OF THE FIRST IN THE WORLD DEPARTMENT OF RADIOLOGY
Authors: Itskovich I. E. , Alexandrov K. Yu.
Published: October 2019

The article reflects the stages of development of the first in the world department of radiology throughout the century. During the existence of the department, it was headed by eminent scientists. Under their leadership, the department staff made an invaluable contribution not only to the development of radiology as a science, but also to the development of teaching this specialty in the USSR. The traditions of innovation and teaching excellence laid down by the founders of the department are preserved and developed at the present stage.
DIRECT COMPARISON BETWEEN DIFFUSION-WEIGHTED MRI AND PET/CT WITH [11С]METHIONINE IN PATIENTS WITH CEREBRAL GLIOMAS
Authors: Skvortsova T. Yu. , Savintceva Zh. I. , Zakhs D. V. , Gurchin A. F. , Kholyavin A. I. , Trofimova T. N.
Published: October 2019

The aim of the study was to assess the diagnostic value of MR diffusion imaging (DWI) and hybrid positron emission and computed tomography (PET/CT) with [11C]methionine for glioma grading and to compare the spatial distribution of diffusion restriction and [11C]methionine uptake abnormalities within a tumor.

Material and methods: MRI with diffusion sequences and PET/CT with [11C]methionine were performed for 46 patients with untreated histologically proven brain gliomas. Quantitative evaluation included the minimal apparent diffusion coefficient value (ADCmin) in the tumor and maximum [11C]methionine uptake ratio, measured as ratio of highest tumor count density to that of the brain cortex(tumor-to-cortex-T/Cmax). Mean measurements of ADC (ADCmean) and T/C (T/Cmean) were obtained for each tumor. The ADC and T/Cratio values for glioma grading were assessed and correlations were evaluated. In addition PET and ADC images were coregistered to each other.

Results: The T/Cmax and ADCmin values were significantly negatively correlated (r=–0,82). The T/Cmean and ADCmean measurements also demonstrated the significant negative correlation (r=0,56). The T/Cmax showed best accuracy in glioma grading. Sites of maximal radiotracer uptake and minimal ADC did not match in 34% of cases and in 66% of tumors the match was partial.

Conclusion: Diagnostic accuracy of PET/CT using [11C]methionine in glioma grading exceeds DWI-MRI, and for both methods it is preferable to analyze a small tumor volume. The T/C ratios and ADC measurements demonstrate the significant inverse correlations. High rate of mismatch between spatial distribution of increased [11C]methionine uptake and low ADC areas within a tumor could be a result of different biological features registered by PET and DWI.
REALIZATION OF TRANSFORMATION AND CREATIVE POTENTIAL OF THE KRYLATIKA IN MEDIA DISCOURSE
Authors: Makarova Alexandra S.
Published: October 2019

The modern process of the mediatisation of all spheres of public life affects both the volume of speech creation and the media texts themselves. The mass character and the multi-language openness of media discourse allow us to consider winged units as a means for representing and imple- menting phraseological innovations. The role of mass media in the formation of new sustainable turns is being actively studied, which speaks of their significance in this process, since it is the media discourse that demonstrates most clearly the current usage and viability of phraseological innovations in language and speech. The media discourse has a large number of ways of influencing the mass addressee, and, as recent studies of Russian media texts show, the fund of winged units as an integral part of the phraseological corpus of the national language is widely used in it. Various phrase resources (idioms, winged expressions, paremias, aphorisms, etc.) are often used both in a strong text position - the title or ending of the publication, and in the creation of media texts connecting the verbal and visual parts in which their transformational and creative potential is most clearly realized, multiplying their linguo-pragmatic effect on the addressee. The analysis of the media content of the site “Orthodox Laughs” revealed the tendency of creative use of folklorism “Баю-баюшки-баю, не ложися на краю. Придет серенький волчок - И укусит за бочок!”, which has not yet been fixed by lexicographical practice, as well as its variants that are the result of various methods of transformation language units. Structural and semantic transformations of various categories of phraseological units are an effective means of implementing specific expression in the media text. Previously, fiction was considered the main source of winged units, today the situation is changing, and the leadership belongs to synthetic art forms (cinema, television, pop, etc.). The analyzed potential winged unit has not one source of appearance: along with Russian and German folklore, this is German literature, but the expression in the Soviet animated film “The Bremen Town Musicians” was actualized. In analyzing the publications of this site, interdisciplinary methods of studying media content were used: discursive, descriptive-analytical, linguocultural, and media linguistic. The conducted research has shown that the functioning of the considered potential winged unit and its transforms confirms the thesis that these language units are in demand and widely used in modern media texts, since they have productive mechanisms of meaning formation.