bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of a New Real-Time Molecular Assay for the Detection of Babanki Virus in Africa
Authors: Faye Martin , Ban Mathilde , Top Fatou Kiné , Ndiaye El Hadji , Thiaw Fatou Diène , Fall Gamou , Diagne Moussa Moise , Sall Amadou Alpha , Diallo Mawlouth , Choumet Valérie , Faye Ousmane
Published: November 2024

Babanki virus is a subtype of the Sindbis virus, a widespread arthropod-borne alphavirus circulating in Eurasia, Africa, and Oceania. Characterized by rashes and arthritis, clinical infections due to Sindbis were mainly reported in Africa, Australia, Asia, and Europe. However, its sub-type, Babanki virus, was reported in Northern Europe and Africa, where its epidemiology potential remains poorly understood. The diagnosis of alphaviruses is mainly based on serological testing and conventional PCR methods, which have considerable limits. In this study, we developed a real-time qRT-PCR assay for the detection of Babanki virus. The analytical sensitivity and specificity of the newly established assay were evaluated using in vitro standard RNA and related viruses relevant to the African context, respectively. In addition, its diagnostic sensitivity was assessed using a subset of Babanki virus-positive and -negative mosquito pools collected from the field. The new real-time qRT-PCR assay exhibited a 100% specificity, a 95% detection limit of 1 RNA molecule/reaction, and a diagnostic sensitivity of up to 120 pfu/reaction. This newly established assay could be useful not only for the detection of Babanki virus during epidemics but also in future experimental and surveillance studies focusing on their epidemiology and pathogenicity.
Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination
Authors: Ferraresi Francesca , Anticoli Simona , Salvioli Stefano , Pirazzini Chiara , Calzari Luciano , Gentilini Davide , Albano Christian , Di Prinzio Reparata Rosa , Zaffina Salvatore , Carsetti Rita , Garagnani Paolo , Ruggieri Anna , Kwiatkowska Katarzyna Malgorzata
Published: November 2024

Background/Objectives: HBV infections can lead to serious liver complications that can have fatal consequences. In 2022, around 1.1 million individuals died from HBV-related cirrhosis and hepatocellular carcinoma. Vaccines allow us to save more than 2.5 million lives each year; however, up to 10% of vaccinated individuals may not develop sufficient protective antibody levels. The aim of this study was to investigate the epigenetic drift in the response to HBV vaccine in isolated B cells. Methods: Epigenetic drift was measured by counting rare DNA methylation variants. These epivariants were detected in epigenome-wide data collected from isolated B cell samples from 41 responders and 30 non-responders (age range 22–62 years) to vaccination against HBV. Results: We found an accumulation of epivariants in the NR group, with a significant increase in hyper-methylated aberrations. We identified the chromosomes (1, 3, 11, 12, and 14) and genes (e.g., RUSC1_AS1 or TROVE2) particularly enriched in epivariants in NRs. The literature search and pathway analysis indicate that such genes are involved in the correct functioning of the immune system. Moreover, we observed a correlation between epigenetic drift and DNA methylation entropy in the male population of the cohort. Finally, we confirmed the correlation between epivariant loads and age-related epigenetic clocks. Conclusions: Our findings support the idea that an age-related derangement of the epigenetic architecture is involved in unresponsiveness to the HBV vaccine. Furthermore, the overall results highlight the interconnection between various epigenetic dynamics (such as drift, clocks, and entropy), although these interconnections seem not to be involved in the altered immunological activity.
Systemic Granulomatosis in the Meagre Argyrosomus regius: Fishing for a Plausible Etiology
Authors: Murgia Claudio , Cubeddu Tiziana , Burrai Giovanni P. , Alberti Alberto , Bertolotti Luigi , Colitti Barbara , Prearo Marino , Pastorino Paolo , Esposito Giuseppe , Mandrioli Luciana , Barbera Gaspare , Sanna Marina Antonella , Polinas Marta , Soto Esteban , Antuofermo Elisabetta
Published: November 2024

Meagre (Argyrosomus regius) is one of the fast-growing species considered for sustainable aquaculture development along the Mediterranean and Eastern Atlantic coasts. The emergence of Systemic Granulomatosis (SG), a disease marked by multiple granulomas in various tissues, poses a significant challenge in meagre aquaculture. In the current study, we investigate the association of Mycobacterium spp. and SG in offshore aquaculture facilities in Sardinia, Italy. A total of 34 adult seemingly healthy meagre were arbitrarily collected and analyzed, combining histological, microbiological, molecular, metagenomics, and in situ techniques to investigate the presence of pathogens. Ziehl–Neelsen (ZN), periodic acid–schiff (PAS), and Giemsa stains were performed for the detection of acid-fast bacteria, common parasites, and fungi within granulomas, respectively. Granulomas were detected in 91% (31/34) of fish. The affected organs were kidney (88%), liver (47%), heart (41%), intestine (17.6%), and brain (5%). Acid-fast staining, along with Mycobacterium spp. specific quantitative PCR (qPCR), in situ hybridization (ISH) assay, and microbiological analyses showed negative results for the detection of Mycobacterium spp. and other bacteria implicated in granuloma formation. However, PCR amplification and sequencing of the 65-kDa heat shock protein gene revealed the presence of M. chelonae in 13% of both formalin-fixed and frozen liver tissues. Bacterial isolation failed to detect nontuberculous mycobacteria (NTM) and other bacteria typically associated with granulomas. Consistently, the use of an M. chelonae-specific probe in ISH failed to identify this bacterial species in granulomas. Collectively, results do not support the role of M. chelonae in the development of granulomas and suggest rejecting the hypothesis of a potential link between NTM and SG.
First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure
Authors: Groppetti Debora , Pizzi Giulia , Giussani Elisa , Pecile Alessandro , Mazzola Silvia Michela , Bronzo Valerio , Fusi Eleonora
Published: November 2024

Tobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. Additionally, seminal cotinine concentrations were correlated with those in serum and hair. To further examine the potential impact of smoking on canine fertility, the relationships between seminal cotinine, total sperm concentration, and antioxidant activity in plasma and semen were analyzed in exposed and non-exposed dogs. This study is the first to demonstrate the presence of cotinine in canine ejaculate and its correlation with blood and hair concentrations. While the potential toxic effect of cotinine on seminal parameters and male fertility in dogs requires further investigation, it is crucial to raise awareness among pet owners about the risks associated with domestic smoking for their animals.
Molecular Investigations of Babesia caballi from Clinically Healthy Horses in Southwestern Romania
Authors: Giubega Simona , Ilie Marius Stelian , Morariu Sorin , Imre Mirela , Dreghiciu Cristian , Rugea Tatiana , Ivascu Simina , Simion Gheorghița , Dărăbuș Gheorghe
Published: November 2024

Babesia caballi is a tick-borne hemoparasite that causes equine piroplasmosis. It has a significant economic impact, decreasing performance and affecting animal welfare. This study aimed to identify B. caballi DNA in the blood of horses from households in the southwestern and western regions of Romania. We included 310 animals, from which blood was collected via EDTA. To test the samples for the B. caballi parasite genome, we used real-time PCR and conventional PCR. The prevalence of B. caballi was 5.81% (18/310) in apparently healthy horses, suggesting that this parasite is enzootic in the regions studied, although veterinarians did not indicate any symptoms resembling clinical babesiosis. In Romania, there are insufficient epidemiologic data on equine babesiosis, and the results of the present study suggest the need for further investigations into the dynamics of transmission and to identify potential prevention and control strategies.
Research on Efficiency Improvement Technology of Wide Range Centrifugal Pump Based on Genetic Algorithm and Internal Flow Loss Diagnosis
Authors: Liu Zhenbo , Ji Leilei , Pu Wei , Li Wei , Yang Qiaoyue , Zhang Xing , Yang Yang , Shi Weidong , Tian Fei , Jiang Sen , Agarwal Ramesh
Published: November 2024

Wide-flow centrifugal pumps are widely used in marine, petrochemical, and thermal power plants because of their good hydraulic performance. To enhance the hydraulic performance of wide-flow centrifugal pumps and thereby reduce energy consumption, in this study, an automatic optimization system for rotating machinery based on genetic algorithms was employed. Initially, a detailed description of the centrifugal pump model and the optimization system was provided. Subsequently, sensitivity analysis of key parameters was conducted through design of experiments (DOEs), identifying the primary factors influencing the pump performance. This research demonstrated that the blade wrap angle, as well as the leading and trailing vane exit angles of the front and back shrouds, are crucial factors affecting the performance of the centrifugal pump, with the blade wrap angle exerting a particularly significant impact on pump efficiency, contributing up to 83.6%. After optimization, the pump’s head increased by 1.29%, and the efficiency improved by 2.96%. The flow field of the optimized pump was significantly improved, with enhanced fluidity, achieving higher head and efficiency at a lower torque. Additionally, the pumping performance was augmented with an enhanced diffuser capacity in the pump volute, leading to increased exit pressure energy, while the turbulent kinetic energy and entropy production losses were significantly reduced. Under various operating conditions, the entropy production losses at the pump walls were all decreased, and the total mechanical energy within the impeller showed an increasing trend from the inlet to the outlet, resulting in lower energy consumption. In this paper, a reference is provided for further enhancing the hydraulic performance of centrifugal pumps in the future.
Network Analysis of Water Contamination Discourse on Social Media Platforms
Authors: Ivic-Britt Rebecca Katherine , Boman Courtney D. , Ritchart Amy , Britt Brian Christopher , VanDyke Matthew S.
Published: November 2024

This study examines water contamination issues using social media data (n = 420.7 k) to unveil the roles and patterns from the top 10 most influential users in their respective networks determined by their reply, retweet, and mention networks. Findings from RQ1 show diverse entities within this group, encompassing political figures, organizations, cause-related actors (e.g., EPA), educational institutions, and high-activity accounts all contribute to the discourse on water contamination. While RQ2 sought to examine the evolution of discourse regarding water contamination and its related dynamics, instead, communication “shocks”, or deviations from typical discourse that returned to the original state, were identified, rather than revolutionary moments on social media that triggered long-term changes.
Degradation of Ciprofloxacin in Water Using Escherichia coli and Enterococcus faecium
Authors: Mohy-u-Din Nazish , Farhan Muhammad , Rashid Aneeba , Mohy-u-Din Mehwish , Campos Luiza C.
Published: November 2024

The presence of antibiotics in the wastewater is a growing concern, as they tend to bioaccumulate and are increasing the resistance of bacteria. This study investigates the microbial degradation of ciprofloxacin (CIP) in water using Escherichia coli (E. coli) and Enterococcus faecium (E. faecium). This research aims to degrade the ciprofloxacin antibiotic, which is creating multiple problems in the environment and wastewater. Bacterial strains were isolated from wastewater and sludge samples, and their identities were confirmed through 16S rRNA sequencing. The degradation potential was assessed using a shake flask method under varying conditions, including different antibiotic concentrations, temperatures, pH levels, and inoculum densities. E. coli effectively degraded CIP, achieving 90% degradation at 50 mg/L in 18 days, in optimal conditions like a temperature of 37 °C, a pH of 6.5, and an inoculum concentration of 10−8 CFU/mL. However, at higher concentrations (150 mg/L), degradation decreased. Similarly, E. faecium showed a maximum degradation rate of 100% at 50 mg/L of CIP in 18 days, with optimal degradation occurring at 40 °C, a pH of 6.5, and an inoculum density of 10−8 CFU/mL. This study underscores the effectiveness of selected microbial strains in bioremediation processes, highlighting their potential application in mitigating antibiotic pollution in aquatic environments. This is the preliminary study to explore the potential of isolated bacteria to degrade CIP, and their degradation ability can be utilized to develop a CIP-contaminated wastewater treatment plant.
Assessing Rainwater Quality and Harvesting Potential: A Spatial Analysis in a Medium-Sized City of Colombia
Authors: Matta-Ortíz Andrés Felipe , Güiza-Valdes Iván Agusto , Trujillo-González Juan Manuel , Rojas-Peña Jose Ismael , Torres-Mora Marco Aurelio , García-Navarro Francisco J. , Jiménez-Ballesta Raimundo
Published: November 2024

Rainwater harvesting is a popular artisanal method that provides substantial economic advantages and effectively addresses the issue of water scarcity in many parts of Colombia. This method may not be appropriate from a public health standpoint in every instance. Despite Colombia’s ample precipitation, ensuring a stable water supply is problematic, particularly due to the dramatic fluctuations in weather patterns, such as droughts and severe rainy seasons, which affect the dependability of the water delivery system. This study examines the urban region of Villavicencio with two main objectives: (I) to assess the physico-chemical and microbiological quality of rainwater in the municipality’s residential and commercial sectors; and (II) to analyze the spatial distribution of physico-chemical parameters within the study area. The quality and spatial distribution of rainwater resources in the urban catchment region of Villavicencio were evaluated through the analysis of data obtained from several sampling locations.
Bibliometric Analysis of Research on the Effects of Conservation Management on Soil Water Content Using CiteSpace
Authors: Du Can , Wu Yuexi , Ma Limei , Lei Dong , Yuan Yin , Ren Xiaohua , Wang Qianfeng , Jian Jinshi , Du Xuan
Published: November 2024

As global climate change intensifies and population growth continues, water scarcity has emerged as a critical constraint to sustainable agricultural development. Conservation management, an effective water-saving technique, plays a crucial role in enhancing soil water content (SWC) and promoting sustainable agriculture. This study utilizes CiteSpace to perform a bibliometric analysis of research literature on the effects of conservation management on SWC, encompassing publications indexed in the Web of Science database from 1992 to 2024. By systematically examining 599 papers, we analyzed key research institutions, authors’ collaborative contributions, keyword co-occurrences, and shifts in research hotspots related to conservation management and its impact on SWC. The results reveal that significant topics in this field include “conservation agriculture”, “water use efficiency”, and “conservation tillage”. China (225, 38%) and the United States (129, 22%) lead in publication volume, whereas European countries and institutions show a higher degree of collaboration. The research focus has transitioned from examining the impacts and mechanisms of conservation tillage on crop yield and soil physical and chemical properties to long-term monitoring, water use efficiency, and mitigation. Furthermore, keyword co-occurrence and temporal analysis highlight a growing emphasis on soil quality and greenhouse gas emissions. In the future, it remains imperative to enhance the implementation of automated monitoring systems, secure long-term continuous monitoring data, promote conservation agriculture technology, and bolster the early warning network for extreme climate events. These measures are crucial for preserving soil nutrient levels and ensuring the sustainable development of agriculture.
Chankanai Zeolite Modified with Heteroatomic Derivatives of 3-Aminopropyltriethoxysilane as an Effective Sorbent for Ag(I), Co(II)
Authors: Nalibayeva Arailym M. , Adamovich Sergey N. , Bold Amangul , Zhangabayeva Assem K. , Abdikalykov Yerlan N. , Oborina Elizaveta N. , Kim Olga K. , Rozentsveig Igor B.
Published: November 2024

Bis-N,N-(3-triethoxysilylpropyl)thiosemicarbazide 3 was obtained by the condensation of 3-aminopropyltriethoxysilane 1 with thiosemicarbazide 2. Ethyl ether N-[3-(triethoxysilyl)propyl]-b-alanine 5 was obtained by the interaction of an equimolar amount of aminopropyltriethoxysilane 1 and ethyl acrylate 4 (aza-Michael reaction). Synthesized functional organosilanes 3 and 5 were successfully immobilized on the surface of natural zeolite Z (Chankanai deposit, Kazakhstan). Compounds and materials have been studied by NMR and IR Fourier spectroscopy and X-ray diffraction analysis. The elemental composition and morphology of modified zeolites Z3 and Z5 were studied using SEM-EDX analysis. The modification of zeolite by organosilanes 3 and 5 leads to changes in the surface structure of the material: with the enlargement of particles and agglomerates, the surface becomes more homogeneous and less porous. This indicates a high degree of zeolite coverage by the modifier layer. The study of the sorption characteristics of the initial Z and modified zeolites (Z3 and Z5) showed a high sorption capacity relative to Ag(I) and Co(II) (static sorption capacity, SSC = 35.85–23.92 mg/g), whereas the SSC values for Z were SSC = 20.63 and 16.64 mg/g. The adsorption of Ag(I) and Co(II) ions was studied in solutions prepared using Co(NO3)2·6H2O, AgNO3 and distilled water. The choice of the initial concentration of metal ions, as well as the pH of the solutions, corresponded to the composition of wastewater from real electroplating production. Zeolites Z3 and Z5 can be used in various sectors of industry, in ecology and for medical purposes as inexpensive and effective adsorbents (enterosorbents) of heavy and noble metals.
A Protocol for the Characterization of Diatom Communities in Mountain Glaciers
Authors: Chamorro Susana , Borrego-Ramos María , Silva Carlos , Estrada Dayana , López Sara , Salazar José , Moyón Jennifer , Becares Eloy , Blanco Saúl
Published: November 2024

This research presents a significant contribution to the methodologies and protocols for studying diatom communities in cryoconite holes on glaciers. Cryoconite holes are unique microenvironments found on glacial surfaces that support intricate microbial ecosystems, with diatoms playing a pivotal role in these communities. The refined methodologies developed in this study include optimizing sampling techniques to ensure that collections are both representative and diverse, which is crucial for accurate ecological assessments. Additionally, advanced digestion processes have been implemented to effectively isolate and purify diatom samples while minimizing contaminants, thereby improving sample integrity. Improved microscopic mounting techniques enhance visual clarity, facilitating more precise identifications of diatoms under the microscope. Furthermore, integrating DNA-based taxonomy broadens the taxonomic scope, providing valuable molecular insights into the diversity and evolutionary relationships of diatoms. Collectively, these protocols aim to enhance the reliability, depth, and multidimensional understanding of diatom ecology in cryoconite holes and broader glacial ecosystems, ultimately contributing to the field of glaciology and microbial ecology.
Determining Volt/Var Characteristics of Electric Vehicle Charging Station Inverters for Voltage Regulation in Distribution Networks
Authors: Voronin Vyacheslav , Nepsha Fedor , Ilyushin Pavel
Published: November 2024

In this paper, a method for determining the parameters of the Volt/Var characteristics of inverters of electric vehicle charging stations to regulate voltage in distribution networks is proposed, which differs from the existing ones by taking into account the possibility of the joint control of active and reactive power and the impedance of the power distribution line. The method proposed in this paper allows researchers to determine the slope and width of the dead band of the Volt/Var characteristics according to the criterion of limiting the maximum voltage deviations to an acceptable value or maximizing the reactive power of the inverter upon reaching a specified voltage. To test this method, a quasi-dynamic modeling of the distribution network with electric vehicle charging stations regulating voltage using the Volt/Var characteristics was performed. Based on the modeling results, it is shown that fast electric vehicle charging stations can be used to regulate voltage in the distribution network with relatively minor constraints on the charging active power.
The role of environmental objects in maintaining the epidemic process of geohelminthiasis in the Astrakhan region in 2023
Authors:   Astrakhan State Medical Universit y of the Ministry of Health of the Russian Federation, Astrakhan, Russia, Arakelyan R. S. ,   Center of Hygiene and Epidemiology in the Astrakhan region, Astrakhan, Russia, Bessonova T. A. ,   Center of Hygiene and Epidemiology in the Astrakhan region, Astrakhan, Russia, Kuznechikova A. S. ,   Center of Hygiene and Epidemiology in the V olgograd region, Volgograd, Russia, Samieva S. A. ,   City polyclinic No. 3», Astrakhan, Russia, Sadretdinova A. F. ,   Astrakhan State Medical Universit y of the Ministry of Health of the Russian Federation, Astra - khan, Russia, Ismailova M. ,   Astrakhan State Medical Universit y of the Ministry of Health of the Russian Federation, Astra - khan, Russia, Germikhanov I. A. ,   Astrakhan State Medical Universit y of the Ministry of Health of the Russian Federation, Astra - khan, Russia, Ismailov S. D. ,   Astrakhan State Medical Universit y of the Ministry of Health of the Russian Federation, Astra - khan, Russia, Adinuzelova Z. N. ,   Astrakhan State Medical Universit y of the Ministry of Health of the Russian Federation, Astra - khan, Russia
Published: November 2024

Modern science knows more than 300 different human helminthic infestations, the
pathogens of which are able to enter the human body using various mechanisms, pathways and
transmission factors. Often, various environmental objects, such as soil and water, serve as
transmission factors. The purpose of the study is to study and analyze the parasitic contamination
of environmental objects (soil and water) — factors of transmission of pathogens of geohelminthiasis
in the Astrakhan region. The role of sanitary and parasitological monitoring in the
epidemiological surveillance of geohelminthiasis is shown. It was found that the contamination
of environmental objects in the Astrakhan region is 4.0 %. Among the priority findings in soil
and water samples collected in the region in 2023 are mobile larvae of Strongyloides stercoralis,
eggs of toxocara and ascaris. When comparing the frequency of detection of positive samples in
soil and water, it was found that soil contamination of 4.7 % (95 % CI 3.6–5.8) was significantly
higher than that of water — 1.1 % (95 % CI 0–2.3), which indicates a higher role of the former
in maintaining the epidemic process of geohelminthiasis in the Astrakhan region.
Psychoemotional stress and the quality of life of doctors and secondary medical workers in conditions of high epidemic risk
Authors:   Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia, Babanov S. A. , Ostryakova N. A. ,   Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia, Lysova M. V. ,   Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia
Published: November 2024

The COVID-19 pandemic, due to a drastic change in the standard work schedule, had a negative
impact on the psychological health of medical workers, expressed in an increase in the level of psychological discomfort and occupational stress. The aim is to assess the features of a decrease in the quality of life
of doctors of therapeutic and surgical specialties, nurses working in a specialized COVID — 19 hospital,
a multidisciplinary hospital, and a polyclinic during the pandemic of a new coronavirus infection. It was found that there was a significant decrease in the parameters of all the studied indicators in the groups of doctors of therapeutic and surgical specialties, as well as nurses (with the exception of the indicators «social functioning» and «viability») working in COVID hospitals, compared with the control group, which indicates a significantly higher level of psychoemotional stress among employees of this category. The
decrease in the quality of life of medical personnel during the COVID-19 pandemic is primarily due to a
violation of the usual rhythm of life and excessive psycho-emotional stress associated with responsibility for the life and health of patients. The data obtained in the course of this study can be used to develop approaches to psychological rehabilitation of medical workers.
Yeni Bir Temsiliyet Yaratma Biçimi Olarak Osmanlı’da Kartvizitler
Authors: Şenyurt Oya
Published: November 2024

Osmanlı toplumunda Batı dünyası ile ilişkiler yoğunlaşınca imza ve kartvizit kullanımının da arttığı görülür. 19. yüzyılın ikinci yarısından sonra kartvizitler etkin biçimde ve çeşitli amaçlarla kullanılmıştır. Makalede 19. yüzyılın sonlarında Osmanlı dünyasında kartvizitlerin kullanımı ve kullanımlarına ait engeller ve sakıncalar Osmanlı arşiv belgelerine dayandırılarak değerlendirilmiştir. Yapılan araştırmada kartvizitlerin sadece ticarȋ ilişkilerde tarafların birbirlerini tanımaları için kullanılmadığı ortaya çıkmıştır. Kartvizitler aynı zamanda bir kimlik belgesi olarak değerlendirilmişler ve önemsenmişlerdir. Ancak kartvizitlere bu kadar önem verilmesi kişilerin kimlikleri ve talepleri hakkında yanılgılar yaşanmasına da sebep olmuştur. Kartvizitlerin kişi hakkında bazı kanaatlerin oluşmasına neden olacağı düşünüldüğünden kişiler kendisini doğrudan ifade etme biçimi yerine kendisi ile hiç ilgisi olmayan bazı logoları ve görsel malzemeyi kartvizitlerde kullanmıştır. Ayrıca kartvizitlerin sahteleri üretilmiş ve sahibi dışında başkaları tarafından kullanılmışlardır. Sonuç olarak kartvizitler kişilerin kendisini tanıtımında ve reklam amaçlı kullanılabildiği gibi bazıları siyasi, dini sebeplerle sakıncalı bulunmuş ve kimi zaman propaganda ve protesto amaçlı kullanımı hükümet tarafından engellenmeye çalışılmıştır.
From Technophobia to Techno confidence: Integration of iPad Software Applications in Teacher Training
Authors: Naidoo Rosann Chantel
Published: November 2024

The COVID-19 pandemic had a profound effect on higher education worldwide, underscoring the need for effective technology integration to enhance teaching and learning. This study aimed to address technophobia by introducing four iPad software applications to a group of 35 first-year Bachelor of Education preservice teachers specializing in the Intermediate phase at a private higher education institution in Westville, KwaZulu-Natal, South Africa. Conducted over six weeks in the second semester of 2024, the qualitative case study collected data through pre-intervention questionnaires, classroom use of Stop Motion, iMovie, Keynote and Plotogon in mathematics, natural science, and technology lessons, and a post-intervention focus group discussion. The findings demonstrated strong technological engagement under instructor guidance, with 91% of participants using at least one application during the intervention. The primary objective was to enhance preservice teachers' Technological Pedagogical Content Knowledge and reduce technophobia through hands-on experiences with iPad software applications. The findings revealed that preservice teachers envisioned using these four applications to create interactive, engaging, and student-centered classrooms, where learning is enriched through collaboration, creativity, and subject-specific tools for mathematics, natural science and technology. While many preservice teachers found the software applications easy to use, concerns about accessibility and teacher proficiency, especially due to socioeconomic disparities, highlighted the need for additional technology training. Stop-motion, Keynote and iMovie iPad software applications were believed to be crucial for developing technological pedagogical content knowledge, with Keynote particularly effective for blending abstract topics and concepts with innovative teaching strategies. It was recommended that Keynote be integrated into teacher training to create engaging worksheets and presentations. Stop Motion and iMovie could be used to create entertaining and interactive animations. Interestingly, the findings revealed that Plotagon was not used by the preservice teachers, possibly indicating technophobia or a lack of familiarity and confidence with the iPad software application. The study emphasized the importance of incorporating iPad software applications to assist primary school preservice teachers in overcoming technophobia and building confidence in technology integration. This integration of Stop Motion, Keynote, iMovie, and Plotogon could enhance teacher and learner experiences through creative and innovative instructional designs in mathematics, natural science, and technology.
ESTIMATES OF THE SOLUTIONS OF OPERATOR EQUATIONS UNDER UNCERTAINTY
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, oleksandrnakonechny@knu.ua, Nakonechnyi O.G. , Zinko P.M. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, petro.zinko@knu.ua, Zinko T.P. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, taras.zinko@knu.ua
Published: November 2024

The paper focuses on finding the guaranteed estimates for rectangular matrices that satisfy the linear operator equations with unknown right-hand sides. Under certain assumptions, it is shown that guaranteed estimates of matrices can be found as the solutions of systems of operator equations. In the case where observation data are given with deterministic errors, which belong to certain bounded sets, we obtain the expressions for upper and lower estimates of the solutions of such equations, as well as expressions for upper and lower errors of such estimates. The obtained results are illustrated by an example.

Keywords: linear operator equation, operator core, conjugate operator, guaranteed a posteriori estimate of matrix, guaranteed a posteriori error of the estimate of matrix, minimum by norm solution of the equation.
APPLICATION OF SYSTEM ANALYSIS AND MATHEMATICAL APPARATUS OF FUZZY LOGIC FOR MODELING OF THE PROCESS OF ASSESSING THE FINANCIAL STATE OF THE ENTERPRISE
Authors:   Vinnytsia National Technical University, Vinnytsia, Ukraine, azarova.angelika@gmail.com, Azarova A.O. , Krak Iu.V. ,   Taras Shevchenko National University of Kyiv; V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Iurii.krak@knu.ua, Nikiforova L.O. ,   Vinnytsia National Technical University, Vinnytsia, Ukraine, nikiforova@vntu.edu.ua, Azarov O.D. ,   Vinnytsia National Technical University, Vinnytsia, Ukraine, azarov@vntu.edu.ua, Belyakova K.S. ,   Vinnytsia National Technical University, Vinnytsia, Ukraine, Belyakovakaterina001@gmail.com
Published: November 2024

The article analyzes the available theoretical studies on assessing both the financial state and financial stability of an enterprise based on various approaches, including bankruptcy models, simulation modeling, etc. This made it possible for the authors of the article to develop their own mathematical and structural models of the process of assessing the financial state of the enterprise by means of system analysis, as well as its formalization based on the apparatus of fuzzy logic. A set of aggregating functions for summarizing quantitative evaluation parameters describing the financial stability, liquidity and solvency, business activity, and profitability of the enterprise under study is substantiated. Moreover, the mathematical model took into account the company’s business reputation, which is evaluated based on five qualitative parameters, to obtain an accurate resulting decision. The experimental pool of verification of the developed model for assessing the enterprise’s financial state is 15 enterprises.

Keywords: system analysis, mathematical modeling, fuzzy logic, assessing of enterprise’s financial state.
INTELLIGENT SYSTEM OF DIAGNOSTIC HUMAN ADAPTATION TO EXTREME DISTURBANCE
Authors:   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, aralova@ukr.net, Aralova N.I. , Chikrii A.A. ,   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, g.chikrii@gmail.com, Shakhlina L.Ya.-G. ,   National University of Ukraine on Physical Education and Sport, Kyiv, Ukraine, sportmedkafedra@gmail.com
Published: November 2024

An intelligent system for diagnosing the human body’s adaptation to extreme disturbances of the external and internal environment is proposed. The components of the system are mathematical models of transport and mass exchange of respiratory gases, self-organization of the respiratory and circulatory systems, heat exchange and heat transfer systems, and the immune response system, their interaction and mutual influence.

Keywords: intelligent diagnostic system, mathematical model of the functional respiratory system, interaction and mutual influence of the functional systems of the body, adaptation of the body to extreme disturbances.
TWO-STAGE TRANSPORTATION PROBLEM WITH TWO-SIDED CONSTRAINTS ON CONSUMER DEMANDS AND UPPER BOUNDS FOR CAPACITY OF INTERMEDIATE POINTS
Authors:   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, stetsyukp@gmail.com, Stetsyuk P.I. , Stovba V.O. ,   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, vik.stovba@gmail.com, Khomiak O.M. ,   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, khomiak.olha@gmail.com, Stetsyuk M.G. ,   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, danilyukm5@gmail.com
Published: November 2024

A mathematical model of a two-stage transportation problem with two-sided constraints on consumer demands and upper bounds on the bandwidths of intermediate points is considered. The necessary and sufficient conditions of consistency of the linear constraints system of the corresponding linear programming problem are substantiated. Two mathematical models of a two-stage transportation problem are presented, to which the initial model can be reduced. The results of computational experiments on applying the problem described to the optimal set partitioning problem using the CPLEX solver from the NEOS server are presented.

Keywords: two-stage transportation problem, linear programming problem, constraint system compatibility, optimal set partitioning, CPLEX, NEOS.ming problem, constraint system compatibility, optimal set partitioning, CPLEX, NEOS.
MATHEMATICAL MODELING OF THE T-IMMUNE RESPONSE IN COVID-19
Authors:   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, konstantin_atoyev@yahoo.com, Atoyev K.L. , Knopov P.S. ,   V.M. Glushkov Institute of Cybernetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine, knopov1@yahoo.com
Published: November 2024

A mathematical model has been developed to study the impact of the state of collective immunity on the dynamics of the COVID-19 pandemic. The model accounts for different components of the immune system and allows for the investigation of mechanisms that lead to metastable chaos during the immune response. The relationship between cellular energy states and the dynamics of the immune response has been studied. The problem of optimal control of the immune response is considered, with the aim of minimizing the risk of pathological disorders associated with excessive inflammation due to cytokine release syndrome in the body during COVID-19. It has been shown how changes in different components of the immune system affect the duration of the disease. The dependence of the total number of virus-infected cells on the changes in the balance of energy synthesis and expenditure in cells has been determined.

Keywords: mathematical modeling, T-immune response model, COVID-19, optimal control, deterministic chaos.
ДОМ И САД С.Н.ДУРЫЛИНА В БОЛШЕВО КАК ПРОСТРАНСТВО КУЛЬТУРЫ
Authors: Георгий Владимирович Нефедьев
Published: November 2024

Дом С.Н. Дурылина в Болшево становится центром духовной культуры Подмосковья в1930-950-х годах XX в. На основании мемуарных свидетельств современников и гостей Дома, а также архивных материалов, хранящихся в Мемориальном Доме-музее С.Н. Дурылина, предлагается проект реконструкции аутентичного облика сада. Обосновывается необходимость реставрации дурылинского сада как важного компонента уникального центра культуры.

The article is devoted to a unique garden located around the S.N. Memorial House-Museum Durilina in Bolshevo. Built in 1936, the House becomes the center of the spiritual culture of the Moscow Region in the 1930s and 1950s of the 20th century. Based on memoirs of contemporaries and guests of the e-House, as well as archival materials stored in the Memorial House-Museum of S.N. Durilina, an attempt is being made to reconstruct the appearance of the garden as it was during the life of its owner. The article proposes to begin the restoration of the Durylinsky garden with the involvement of all the actual material available in the museum.
ГЕОКУЛЬТУРНАЯ МАТРИЦА КАК ЦИФРОВАЯ ПЛАТФОРМА ИЗУЧЕНИЯ ОБЪЕКТОВ КУЛЬТУРНОГО НАСЛЕДИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Юрий Степанович Путрик
Published: November 2024

Процессы цифровизации затронули и сферу деятельности по учету, сохранению, изучению, популяризации и использованию объектов культурного наследия. Единый государственный реестр объектов культурного наследия народов Российской Федерации представляет собой внушительный цифровой массив сведений, который становится всё более значимой предпосылкой для проведения не только мониторинга, но и более глубоких исследований о состоянии и тенденциях в деле охраны и использования объектов культурного и природного наследия на территории России.

Digitalization processes have also affected the sphere of activity in recording, preserving, studying, popularizing and using objects of cultural heritage as a key component of Russian civilization. The Unified State Register of Cultural Heritage Objects of the Peoples of the Russian Federation is an impressive digital array of information, which is becoming an increasingly important prerequisite for not only monitoring, but also more in-depth research on the status and trends in the protection and use of cultural and natural heritage in Russia.
КУЛЬТУРНОЕ И КОНФЕССИОНАЛЬНОЕ ВЛИЯНИЕ РОМЕЙСКОЙ ИМПЕРИИ НА ОКРУЖАЮЩИЕ НАРОДЫ В IX-X ВЕКАХ
Authors: Дмитрий Михайлович Абрамов
Published: November 2024

Культурное и конфессиональное влияние Ромейской империи с одной стороны обогатило традиции и жизнь многих окрестных народов. Огромную роль в этом деле сыграло подвижничество славянских просветителей святых Кирилла и Мефодия. С другой стороны, распространение ортодоксального христианского учения вызвало политическое и военное противостояние между западными и восточными иерархами Вселенской Церкви.

The cultural and confessional influence of the Roman Empire on the one hand enriched the traditions and life of many surrounding peoples. A huge role in this matter was played by the asceticism of the Slavic enlighteners Saints Cyril and Methodius. On the other hand, the spread of orthodox Christian teaching caused political and military confrontation between the western and eastern hierarchs of the Ecumenical Church.
ВЫСТАВОЧНЫЙ КОМПЛЕКС «АТАМАНЬ» В СОЦИОКУЛЬТУРНОМ КОНТЕКСТЕ КРАСНОДАРСКОГО КРАЯ
Authors: Ольга Юрьевна Нельзина
Published: November 2024

В статье рассмотрены вопросы, касающиеся сложившейся культурной среды станицы Тамань Темрюкского района Краснодарского Края. Выделены конкурентные преимущества региона, вместе с тем отмечен ряд существующих проблем, перемены, произошедшие вследствие изменения политической ситуации. Приводится краткое описание деятельности ≪Выставочного комплекса ≪Атамань≫ его влияние на социокультурную среду региона.

The article deals with issues related to the current cultural environment of the village of Taman in the Temryuksky district of Krasnodar Territory. The competitive advantages of the region are highlighted, along with a number of existing problems and changes that have occurred due to changes in the political situation. A brief description of the activities of the ≪Ataman Exhibition complex≫ and its impact on the socio-cultural environment of the region is given.
И.Н. КРАМСКОЙ. РЕЛИГИОЗНАЯ ДРАМА ХУДОЖНИКА. Часть I. ГАЛЛЮЦИНАЦИЯ
Authors: Владимир Николаевич Катасонов
Published: November 2024

В статье, в основном с опорой на эпистолярное наследие И.Н.Крамского, обсуждаются его взгляды на смысл и значение изобразительного искусства. Центром изложения являются религиозные взгляды художника.

The article, mainly based on the epistolary heritage of Ivan Kramskoy, discusses his views on the meaning and significance of fine art. The center of the presentation is the religious views of the artist.
ТРАНСФОРМАЦИЯ ЦЕННОСТНОГО ПОТЕНЦИАЛА МУЗЕЙНОГО ПРЕДМЕТА В УСЛОВИЯХ ИНТЕРНЕТА
Authors: Елена Геннадьевна Саркисова
Published: November 2024

Статья содержит теоретическое исследование феномена музейного предмета и трансформации его ценностного потенциала в условиях Интернета. Рассмотрены свойства, функции, ценности музейного предмета. Представлена содержательная трактовка понятия «ценностный потенциал музейного предмета» в контексте положений музейной аксиологии. Разработана иерархия ценностей музейного предмета. Определено место в ней информационной ценности. Показаны направления трансформации ценности музейных предметов, выставляемых в информационных ресурсах Интернета.

The Article contains a theoretical study of the phenomenon of a Museum object and the transformation of its value potential in the context of the Internet. The properties, functions, and values of a Museum object are considered. The article presents a meaningful interpretation of the concept of "value potential of a Museum object" in the context of the provisions of Museum axiology. The hierarchy of values of a Museum object is developed. The place of information value in it is determined. The article shows the directions of transformation of the value of Museum items displayed in Internet information resources.
ЦЕРКОВНАЯ ШКОЛА КАК ОБРАЗОВАТЕЛЬНЫЙ И КУЛЬТУРНЫЙ ЦЕНТР РОССИЙСКОЙ ПРОВИНЦИИ В КОНЦЕ XIX-НАЧАЛЕ XX ВЕКА
Authors: Татьяна Александровна Красницкая
Published: November 2024

Рассматривается церковная школа как образовательный и культурный центр российской провинции в конце XIX - начале XX века. Анализируется многолетний практический опыт учебных заведений ведомства православного исповедания в решении просветительских задач среди детей и взрослого населения.

The church school as an educational and cultural center of the Russian province in the end of the XIX-the beginning of the XX century is considered by the author on the basis of a wide range of sources. The long-term practical experience of educational institutions of the Department of the Orthodox confession in solving educational tasks among children and adults is analyzed in the article.
СПОР О «ДРЕВНИХ» И «НОВЫХ» В ЦЕРКОВНОМ ИСКУССТВЕ
Authors: Максим Владимирович Крижевский
Published: November 2024

Рассматривается проблема последствий эстетических инноваций в церковном искусстве на примере «Спора о древних и новых» XVII в. и в контексте уроков церковной истории.

The problem of the consequences of aesthetic innovations in church art is considered on the example of the "Dispute about the ancient and new" of the XVII century and in the context of lessons of church history.
ТРАРАНСФОРМАЦИЯ СЕМАНТИКИ БОГОРОДИЧНЫХ ИМЕН-ОБРАЗОВ В КОНТЕКСТЕ КУЛЬТУРНОЙ ЯЗЫКОВОЙ ТРАДИЦИИ: ПОСТАНОВКА ПРОБЛЕМЫ.
Authors: Екатерина Александровна Данилова , Галина Александровна Цветкова
Published: November 2024

Рассматривается архетипическая связь образа Богородицы с русской народной культурой. Ставится проблема раскрытия образа Богородицы как культурного феномена. Предлагается осмысление трансформации семантики образа Богородицы на основе сопоставительного анализа уникальных богородичных текстов - перевода свт. Димитрием Ростовским на язык русской православной культуры Псалтири Божией Матери еп. Бонавентуры.

The archetypal connection of the image of the Virgin with Russian folk culture is considered. The problem of revealing the image of the Virgin as a cultural phenomenon is posed. It is proposed to comprehend the transformation of the semantics of the image of the Virgin Mary on the basis of a comparative analysis of the unique Theotokos texts - the translation of svt. Demetrius Rostovsky on the language of Russian Orthodox culture, the Psalms of the Mother of God ep. Bonaventure.
ПАТРИОТИЗМ В ОПЕРАХ СОВЕТСКИХ КОМПОЗИТОРОВ
Authors: Елисей Сергеевич Лаптев
Published: November 2024

Идея патриотизма характерна для множества русских и советских опер, от сочинений М.И. Глинки до творений советских композиторов. В разные исторические эпохи эта идея приобретает разное значение, разное звучание, она по-разному воплощается в жанровых разновидностях оперы. Музыкальный язык выработал ряд приемов и средств для ее воплощения. Их обсуждению посвящена данная статья.

The idea of patriotism is characteristic of many Russian and Soviet operas, from the works of M.Glinka to the works of Soviet composers. In different historical epochs, this idea acquires different meanings, different sounds, it is embodied in different ways in the genre varieties of opera. The musical language has developed a number of techniques and means for its embodiment. This article is devoted to their discussion
ОХРАНА ПАМЯТНИКОВ ВЕЛИКОЙ ОТЕЧЕСТВЕННОЙ ВОЙНЫ В КРЫМУ В 1945-1957 ГГ. В ДОКУМЕНТАХ НАУЧНО-МЕТОДИЧЕСКОГО СОВЕТА ПО ОХРАНЕ ПАМЯТНИКОВ АКАДЕМИИ НАУК СССР
Authors: Андрей Алексеевич Кохан
Published: November 2024

На основе нормативно-правовых актов СССР, РСФСР и УССР, документов Научно-методического совета по охране памятников Академии наук СССР, хранящихся в научном архиве ФГБНИУ «Российский-научно исследовательский институт культурного и природного наследия имени Д. С. Лихачева», реконструируется организация учета и сохранения памятников, связанных с событиями Великой Отечественной войны в Крыму.

The article discusses the issues of accounting and preservation of monuments associated with the events of the Great Patriotic War in the Crimea in 1945-1957. in the light of the regulatory legal acts adopted by the governments of the USSR, the RSFSR and the Ukrainian SSR, and in the light of the documents of the Scientific and Methodological Council for the Protection of Monuments of the USSR Academy of Sciences, deposited in the scientific archive of the Likhatchev Russian Research Institute for Cultural and Natural Heritage.