bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of SARS-CoV-2 variants related mutations in wastewater using RT-qPCR and variant-specific probes in Porto Alegre, Southern Brazil
Authors: Mangini Arthur Tonietto , Prandi Bruno Aschidamini , Violet-Lozano Lina , Cunha Pâmela Ferreira , Jarenkow Andre , Campos Aline Alves Scarpellini , Pasqualim Gabriela , Hartke Sara , Brum da Silva Ilma Simoni , Campos Fabrício Souza , Roehe Paulo Michel , Franco Ana Cláudia
Published: October 2024

The COVID-19 pandemic has underscored the significance of monitoring genetic variations in pathogenic viruses to manage its transmission and identify emerging variants. Nonetheless, sequencing every positive patient case is impractical for large-scale testing of the population. Here, we introduce a cost-effective tool for identifying SARS-CoV-2 mutations associated with variants in wastewater. This approach relies on a wastewater surveillance system and reverse transcription-quantitative polymerase chain reaction (RT-qPCR), utilizing mutation-specific probes. Wastewater samples were analyzed for SARS-CoV-2 mutations corresponding to variants under monitoring (VUM) (P.2, alpha, beta, gamma, delta, and omicron) as part of a wastewater-based SARS-CoV-2 monitoring program. Our findings validate the efficacy of this method in detecting SARS-CoV-2 mutations linked to variants in wastewater, facilitating early detection of emerging variants and informing decision-making on control measures.
Contextual and psychological factors in using recycled stormwater for residential purposes: a case study from Taiyuan, China
Authors: Guo Shufen , Wu Zhifang , Keremane Ganesh
Published: October 2024

This paper reviewed the managed aquifer recharge (MAR) practices around the world and explored urban residents' attitudes towards using stormwater recycled through MAR for residential uses in a Chinese socio-cultural context. The exploration was conducted from both contextual and psychological perspectives based on two established theories. The moderating effect of gender on residents' attitudes was tested. The results showed that most respondents supported using recycled stormwater for residential purposes but demonstrated hesitance in using recycled stormwater for uses that present proximity to human contact, which normally requires connecting the water to their house. Regarding the water quality attributes such as the colour, odour, and salt content of recycled stormwater, respondents were more tolerant if the water was used for uses that have limited human contact and less tolerant for uses that have close human contact. Therefore, any future decision to connect recycled stormwater into houses would require careful consideration and investigation as it depends on a range of issues including the proximity to human contact and the quality attributes of the water. Gender was a weak predictor in moderating respondents' attitudes towards using recycled stormwater, which adds to the inconsistent literature.
Fully automated simplification of urban drainage models on a city scale
Authors: Pichler Markus , König Albert Wilhelm , Reinstaller Stefan , Muschalla Dirk
Published: October 2024

The article presents an innovative method for simplifying urban drainage models. This approach strategically reduces complexity while preserving accuracy in large-scale, high-resolution models such as those of the city of Graz. It involves the selective removal and aggregation of sewer network elements like subcatchments and conduits, ensuring vital features like storage nodes and flow controls remain intact for precise simulations. Despite significant reductions in model components, the simplified version maintains high accuracy in hydrological and hydraulic aspects, including water balance components like infiltration loss, surface runoff, and external outflow. The method proves equally effective across both land cover and sewer shed-based models, offering computational efficiencies that speed-up processing by 20–45 times for the study site. This is particularly beneficial for rapid decision-making and resource optimization in urban planning. The model also adeptly predicts flood events, especially from larger, infrequent rainfall, although an overly restrictive flow capacity can refine flood predictions at the expense of other flow characteristics. Ultimately, this streamlined approach allows for the quick creation of simplified, yet accurate, models from high-resolution city-scale hydrodynamic data or digital twins, facilitating efficient and timely analyses in urban drainage management.
2D Materials (2DM) based photocatalyst for environmental remediation
Authors: Chandrapal R. Roshan
Published: October 2024

Creating a sustainable environment is one of the most important issues facing modern society. Together with an increase in human activity and a rise in per capita income, there has been a noticeable population boom. A growing number of people are becoming concerned about whether the natural resources of our planet will be viable in the long run. In addition, pollution of the air, water, and soil has resulted from industrialization, urbanization, and contemporary farming methods. Given the current situation, widespread exploitation and the widespread presence of hazardous substances are posing growing challenges to the ability of future generations to flourish. Water is separated into hydrogen and oxygen in this process, with the hydrogen being used as fuel. For semiconductor-based photocatalysts and materials to be used effectively in photocatalytic degradation processes for environmental remediation and energy conversion applications, a thorough understanding of their characteristics and behavior is essential. 2DM are an emerging class of nanomaterials with exceptional properties. These composites combine the unique qualities of specific 2DM to create new capabilities. To achieve an increased efficiency, a variety of 2D composites (0D/2D, 1D/2D, 2D/2D, and 3D/2D) are used. Two unique 2D materials that can be stacked to create designer materials with particular properties are graphene and hexagonal boron nitride. Materials derived from 2DM-composite provide exciting prospects in the realm of photocatalysts for the degradation of organic pollutants. Because of their varied uses and customizability, they are at the forefront of developing advanced materials for a range of applications. More groundbreaking 2DM composite with game-changing implications for photocatalysis could be in store.
Simulation of the response of a magnetic polymersome in an inhomogeneous magnetic field
Authors: Ryzhkov A. V.
Published: October 2024

Purpose. Identification of the behavior of a magnetic polymersome placed in an inhomogeneous field of a point dipole using coarse-grained molecular dynamics simulations.

Methods. The system under the study is represented as a set of interacting particles of two types: polymeric particles simulating a double layer of an amphiphilic membrane, and magnetic nanoparticles located in the membrane layer. Polymeric particles interact through elastic potentials designed to maintain an equilibrium spherical vesicular geometry. Magnetic nanoparticles interact with each other and external fields as point dipoles. The excluded volume and steric interaction of magnetic particles with polymeric walls are modeled in the form of soft repulsion. The entire system is under isothermal conditions, and the model parameters are chosen according to typical interaction energies relative to thermal fluctuations. A model polymersome with a diameter of about 100 nm in an aqueous solution at 25°C is considered. An inhomogeneous magnetic field is created by a dipole of constant direction located at a fixed distance. The dynamics of the system is monitored by numerical solution of the equations of particles motion with introduced interactions and imposed conditions.

Results. In numerical experiments, the response of the polymersome to a magnetic field was obtained for three values of the parameter describing the inhomogeneity of the field. The problem with a gradual increase in the strength (and its gradient) of the magnetic field near the polymersome is considered. Changes in the magnetization of the system are shown, and the redistribution of the concentration of nanoparticles is analyzed. A simulation of the situation when the center of the polymersome at the initial moment was placed at a point with a fixed value of the magnetic field for three cases of inhomogeneity of the field was carried out. A significant restructuring of the magnetic layer of the vesicle combined with movement of the entire capsule was detected. Estimates are made about the average velocity based on the displacement of the object.

Conclusion. The model allows to evaluate the features of the combined magnetic, structural and mechanical response of the polymersome to an inhomogeneous field in the context of potential applications for controlled delivery of contents into cells.
Mechanical properties of silicone polymer with magnetic filler in magnetic field
Authors: Sutarina I. Y. , Novikov K. K. , Sokolov E. A. , Matarykin K. A. , Rjapolov P. A.
Published: October 2024

Purpose. To investigate the change in the mechanical properties of a magnetorheological silicone elastomer consisting of a polymer filled with magnetite nanoparticles under the influence of an inhomogeneous magnetic field of an electromagnet.

Methods. The experiments were carried out on a magnetic response research facility developed and manufactured independently based on known methods. The value of the deflection angle of the magnetically active receiver was determined by the optical method. Two-component silicone rubbers filled with magnetite particles were studied as samples. The manufactured samples differed in geometric dimensions, magnetic phase concentrations of 1%, 5%, 10% and 20%, and polymerization mechanism. The source of the magnetic field was electromagnets of various sizes connected to power sources. The images were captured using a Micmed 5.0 digital USB microscope.

Results. The analysis of the structure of the manufactured magnetorheological silicone elastomers was carried out, as well as studies of the effect of the magnetic field strength and sample parameters on the deflection angle of the magnetically active cantilever. A theoretical interpretation of the obtained results is proposed.

Conclusion. The experimental dependence of the tilt angle of a magnetically active polymer cantilever on the equilibrium position relative to the magnitude of the magnetic field strength of the electromagnet is determined. The obtained research results can be used to develop actuators and magnetoactive sensors.
Production and research of tungsten carbide powder from VA grade tungsten metal waste in aviation kerosene
Authors: Ageeva E. V. , Lоktionova O. G. , Ulitin D. A. , Ageeva A. E.
Published: October 2024

Purpose. Obtaining and studying the composition, structure and properties of tungsten carbide powder from VA grade tungsten metal waste in aviation kerosene.

Methods. Tungsten carbide powder from tungsten metal waste of the VA brand was obtained in the following sequence. The reactor was filled with a working medium – aviation kerosene of the TS-1 brand, the waste was loaded into the reactor. Electrodes were mounted from the same waste tungsten of the VA brand. The mounted electrodes were connected to a pulse generator. The necessary electrical parameters of the installation were set: the capacitance of the condensers is 42.0–43.5 UF; the voltage on the electrodes is from 115–120 V; the pulse repetition rate is 50–55 Hz. The resulting tungsten powder was studied using: a scanning electron microscope QUANTA 600 FEG; a particle size analyzer Analysette 22 NanoTec; an energy-dispersed X-ray analyzer from the company EDAX; X-ray diffraction on a diffractometer Rigaku Ultima IV.

Results. Based on the conducted experimental studies, a new method for producing tungsten carbide powder has been developed, characterized in that the powder is obtained by electroerosive dispersion of tungsten metal waste of the VA brand in aviation kerosene at a capacitor capacity of 42.0–43.5 UF, an electrode voltage of 115–120 V and a pulse repetition frequency of 50–55 Hz. It has been experimentally established that spherical and elliptical particles of tungsten carbide powder W2C have sizes from 2.26 microns to 90.72 microns with an average volumetric diameter of 20.2 microns and contain carbon on the surface.

Conclusion. The production of tungsten carbide suitable for industrial use at low energy costs from metal waste has shown high efficiency of the technology of electroerosion dispersion.
Practical Recommendations for Navigating Digital Tools in Hospitals: Qualitative Interview Study
Authors: Wosny Marie , Strasser Livia Maria , Kraehenmann Simone , Hastings Janna
Published: October 2024

Background

The digitalization of health care organizations is an integral part of a clinician’s daily life, making it vital for health care professionals (HCPs) to understand and effectively use digital tools in hospital settings. However, clinicians often express a lack of preparedness for their digital work environments. Particularly, new clinical end users, encompassing medical and nursing students, seasoned professionals transitioning to new health care environments, and experienced practitioners encountering new health care technologies, face critically intense learning periods, often with a lack of adequate time for learning digital tools, resulting in difficulties in integrating and adopting these digital tools into clinical practice.

Objective

This study aims to comprehensively collect advice from experienced HCPs in Switzerland to guide new clinical end users on how to initiate their engagement with health ITs within hospital settings.

Methods

We conducted qualitative interviews with 52 HCPs across Switzerland, representing 24 medical specialties from 14 hospitals. The interviews were transcribed verbatim and analyzed through inductive thematic analysis. Codes were developed iteratively, and themes and aggregated dimensions were refined through collaborative discussions.

Results

Ten themes emerged from the interview data, namely (1) digital tool understanding, (2) peer-based learning strategies, (3) experimental learning approaches, (4) knowledge exchange and support, (5) training approaches, (6) proactive innovation, (7) an adaptive technology mindset, (8) critical thinking approaches, (9) dealing with emotions, and (10) empathy and human factors. Consequently, we devised 10 recommendations with specific advice to new clinical end users on how to approach new health care technologies, encompassing the following: take time to get to know and understand the tools you are working with; proactively ask experienced colleagues; simply try it out and practice; know where to get help and information; take sufficient training; embrace curiosity and pursue innovation; maintain an open and adaptable mindset; keep thinking critically and use your knowledge base; overcome your fears, and never lose the human and patient focus.

Conclusions

Our study emphasized the importance of comprehensive training and learning approaches for health care technologies based on the advice and recommendations of experienced HCPs based in Swiss hospitals. Moreover, these recommendations have implications for medical educators and clinical instructors, providing advice on effective methods to instruct and support new end users, enabling them to use novel technologies proficiently. Therefore, we advocate for new clinical end users, health care institutions and clinical instructors, academic institutions and medical educators, and regulatory bodies to prioritize effective training and cultivating technological readiness to optimize IT use in health care.
Interrogating irresponsible Leadership within the Post Independence Matrix in Ngugi Wa Thiong’o’s Wizard of the Crow and Alobwed’ Epie’s The Bad Samaritan
Authors: Wankah Tse-Nwi , Divine Njong , Pangmeshi Adamu
Published: October 2024

The aim of this study is to demonstrate the phenomenon of irresponsible leadership within post-independence nations, exploring its impact on governance, societal development, and sustainability of democratic systems. The problem at hand is multi-faceted. Irresponsible leadership perpetuates a cycle of underdevelopment, erodes trust in government institutions, breeds social unrest, and hinders progress towards sustainable growth and stability. This study intends to answer the following research questions; how does irresponsible leadership affect socio-economic development of post-independence nations? and how do citizens react to to irresponsible leadership in the post-independence matrix? By analyzing , interpreting and evaluating Wizard of the Crow and The Bad Samaritan, we aim to illustrate underlying factors that contribute to irresponsible leadership, drawing parallels with historical and contemporary events. This paper is built on the hypothesis that irresponsible leadership after independence is like a tangled web of power and corruption. By examining this theme closely, the novels demonstrate how leaders can harm society through their actions, highlighting the struggles faced in building a just and fair postcolonial world. This study employs postcolonial theory which is relevant in that, it unveils how historical injustices and imbalances continue to manifest in contemporary governance. Interrogating irresponsible leadership through the postcolonial lens enable us to understand how neocolonial forces and the imposition of Western ideologies contribute to corrupt governance. Drawing upon both primary and secondary sources, this study engages in comparative analyses across varying geographical locations to offer an understanding of the nature of irresponsible leadership. The findings of this study underscore that irresponsible leadership after independence has hindered progress and development in many African countries. The study also revealed that irresponsible leadership has led to economic instability and social unrest in post-independence nations.
Una revisión actualizada sobre los factores de riesgo y características genéticas asociadas a la trombosis venosa profunda
Authors: García Ortega Sebastián
Published: October 2024

Introducción:
La TVP es una de las patologías vasculares más comunes en el mundo, cuya aparición es una combinación de diferentes factores de riesgo tanto genéticos como no genéticos, por lo que se considera una enfermedad prevenible, sin embargo, en la actualidad la identificación de estos factores puede representar un desafío para el clínico, lo que lleva a que esta sea clasificada como no provocada o idiopática. Este artículo tiene como objetivo hacer una revisión sobre los factores de riesgo, tanto genéticos como no genéticos que puedan orientar al clínico en la sospecha y prevención de la TVP.

Metodología:
Se realizó una revisión de la literatura en las bases de datos PubMed y Elsevier con el propósito de recopilar información actualizada sobre los factores de riesgo y características genéticas asociadas a la trombosis venosa profunda (TVP). Se emplearon los términos DeSC de trombosis de vena profunda, trombosis venosa y flebotrombosis juntos con sus equivalencias en MeSH, combinadas con los conectores booleanos AND y OR para refinar la búsqueda. Se revisaron un total de 80 artículos publicados entre 2018 y 2023, los cuales fueron evaluados inicialmente según unos criterios de inclusión y exclusión, seleccionando 50 para ser usados en esta revisión. Los criterios de inclusión comprendieron estudios que abordaran específicamente los factores de riesgo, tanto genéticos como no genéticos para el desarrollo de la TVP y sus generalidades. Se incluyeron estudios de investigación originales y en menor medida artículos de revisión. Los criterios de exclusión se centraron en estudios que no estuvieran disponibles en idioma español o inglés y estudios relacionados con población pediátrica. Se seleccionaron artículos de procedencia global que incluyeran población mayor de 18 años y que se adecuaran al período de publicación entre 2018 y 2023. Se optó por utilizar las bases de datos PubMed y Elsevier debido a su amplia cobertura en medicina y su gran aceptación en la comunidad científica.

Conclusión:
Se evidenció que son múltiples los factores de riesgo que predisponen para la aparición de la TVP, de los cuales, en la mayoría ellos la intervención médica puede impactar positivamente para el desarrollo de la enfermedad, incluyendo las alteraciones genéticas y sus implicaciones.
Phytoconstituent and In silico Screening of Active Compounds from Red Ginger (Zingiber officinale var. rubrum Theilade) Rhizome and Avocado (Persea americana Mill.) Leaves Extracts as Novel Inhibitors of MRSA
Authors: Sari Ni Kadek Yunita , Wiradana Putu Angga , Permatasari Anak Agung Ayu Putri , Widhiantara I Gede , Panjaitan Novaria Sari Dewi , Ansori Arif Nur Muhammad , Pinatih Komang Januartha Putra , Jawi I Made , Suastika Ketut
Published: October 2024

Red ginger rhizome (Zingiber officinale var. Rubrum) and avocado leaves (Persea americana Mill.) are empirically known as one of the medicinal plants used in Taro Village, Gianyar Regency, Bali which have great potential in treating infectious diseases caused by antibiotic resistance, such as MRSA. This study aims to analyze the phytoconstituents and anti-MRSA potential contained in red ginger rhizome and avocado leaves extracts by assessing their inhibitory effects on three proteins related to MRSA resistance and virulence (PBAP2a, transglycosylase, and glycosyltransferase). Phytoconstituents of avocado leaf and red ginger extracts were analyzed using GC-MS. Molecular docking was performed in silico to determine the similarity properties of predicted drugs, bioactivity, toxicity, identification of active sites and validation of protein structures, and docking simulations were performed between compounds found in the extract and their target proteins. Phytoconstituent analysis revealed that avocado leaves and red ginger extracts as a whole have 43 types of compounds and 10 bioactive compounds each with beneficial drug-like properties. The compound 6,11-hexadecadien-1-ol from avocado leaves extracts was predicted to have hepatotoxic properties. There were at least 3 compounds, namely beta-bisabolene from avocado leaves extract, zingiberenol and gamma-curcumene from red ginger rhizome extract, showing the lowest binding affinity for the target protein. Red ginger rhizome and avocado leaves extracts showed valuable potential as anti-MRSA agents through the mechanism of inhibition of three resistance-related proteins, as predicted by in silico analysis.
Determining the Association Between MSP1/2 Variant and Multiplicity of Infection on Incidence of Severe Malaria in Sudanese Children in Gezira State, Sudan
Authors: Alsedeeg Abdalla , Talha Albadawi Abdelbagi , Hussein Sanaa Elfatih , Mohammed Sana Ibrahim , Nour Bakri Yousif M. , Ahmed Abubakr Ali Elamin Mohamed , Alruwaili Yasir , Alruwaili Muharib , Tarabulsi Muyassar K. , Alruhaili Mohammed H. , Selim Samy
Published: October 2024

The Almanagil province located in Gezira scheme, Gezira state, Sudan, represents a suitable environment for the breeding of malaria-carrying mosquitoes. An estimated 5.9% of Sudanese people suffer from malaria, with 87.6% of cases caused by Plasmodium falciparum and 12.4% by Plasmodium vivax. Clinical manifestation of malaria cases range from mild uncomplicated to severe and fatal complications and the genetic variants and multiplicity of falciparum infection can worsen the manifestations of malaria. The objective of this work is to determine the degree of genetic variation in P. falciparum infection in a high-transmission region of central Sudan by analyzing merozoite surface protein-1 (msp1) and merozoite surface protein-2 (msp2) variations. During the rainy season of 2022, Eighty-nine children with confirmed severe falciparum malaria whom admitted to Almanagil Pediatric Hospital were included in this study. Dry blood spots were used to extract the DNA and amplification of three msp1 and two of msp2 allelic subfamilies, namely K1, RO33 and MAD20 and FC27 and IC/3D7, respectively. The data was analyzed by using SPSS computer program (v 23.0). The three genetic subfamilies of msp1 (K1, RO33 and MAD20) and the two alleles of msp2 (FC27 and IC/3D7) were identified. Msp1 variants represent K1 (64/89, 71.9%), RO33 (56/89, 62.9%) and MAD20 (72/89, 80.9%), while msp2 diversity represents ICI/3D7 (52/89, 58.4%), FC27 (62/89, 69.6%) and ICI/3D7/FC27(33/89, 37.1%). The MAD20 and FC27 showed high genetic diversity among both genes respectively. RO33 allele shows a strong association with severity of falciparum malaria (OR 2.572, P 0.045 ), while the K1 was the lowest risk factor for malaria severity. The allele subfamily K1 and MAD20 of msp1 were associated with hypoglycemia (OR 4.21 and 2.91) respectively. Our study revealed high genetic polymorphisms of msp1 and msp2. Among Central Sudanese children with high MOI of P. falciparum isolates, there was a significant frequency of msp1, a strong association between the K1 allele and hypoglycemia, and a substantial association between the RO33 and MAD20 alleles with the severity of the infection. These findings could help develop malaria control strategies.
IoT Based Sign to Speech Converter System
Authors: Nagarale Devyani Pravin
Published: October 2024

The idea introduces a system for facilitating communication between the deaf and the non-signing community through a wearable device called IoT based Sign-to-Speech Converter System. The System consist of glove & it utilizes Internet of Things (IoT) technology to bridge the communication gap by translating sign language (gestures) into spoken language in real-time. The core functionality of the system is augmented by seamless integration with an Android application, enhancing user experience and accessibility. The proposed system leverages a combination of sensors embedded within the glove to capture intricate hand movements and gestures commonly used in sign language. These data are transmitted wirelessly to a central processing unit, to interpret the gestures and generates corresponding spoken language output. The Android application serves as a user interface, allowing for customization of settings and additional features such as text-based communication. Effectiveness and practicality of the proposed system have been demonstrated, opening-up new avenues for inclusive communication and empowerment of the deaf community.
Design of ION Thruster
Authors: Shinde Akshit
Published: October 2024

Ion thrusters represent a significant advancement in electric propulsion, enhancing fuel efficiency by accelerating ions for thrust generation. These systems, demonstrated in missions such as Deep Space 1 and Dawn, facilitate substantial velocity changes with minimal propellant, making them suitable for long-duration space missions. This paper outlines the design of an ion thruster aimed at achieving a thrust of 0.2 Newton, focusing on the use of xenon as the propellant and employing highvoltage grids for ion acceleration. Key design aspects include an efficient power supply delivering at least 26 W, effective thermal management, and the integration of control systems. Performance metrics target a specific impulse of 3,000 seconds and a thrust-to-power efficiency ratio greater than 0.5. Through detailed calculations, including arc distance, flow configuration and velocity analyses and testing using different materials, this study identifies optimal configurations for thrust generation. The developed ion thruster is tailored for small satellites (700-800 kg) to enhance trajectory control and station-keeping, underscoring the importance of ion propulsion in modern space exploration
Performance Analysis of 8x4 Barrel Shifters in CMOS and FINFET Technology
Authors: Sunkara Sowmya
Published: October 2024

Shifters are essential components in digital circuits, enabling data manipulation and routing for a wide range of computational tasks. This study presents a comprehensive performance analysis of 8x4 barrel shifters implemented in two distinct semiconductor technologies: Complementary Metal-Oxide-Semiconductor (CMOS) and FinFET. This study compares and evaluates the important parameters for these shifters at both technological nodes, such as power consumption. Additionally, we examine the effects of scaling on CMOS barrel shifters. Conversely, FinFET technology, recognized for overcoming certain limitations of CMOS, is assessed for its potential to enhance performance while preserving energy efficiency. Through detailed simulation and analysis, this study offers valuable insights into the benefits and limitations of CMOS and FinFET implementations for 8x4 barrel shifters. The circuit is implemented using Cadence Virtuoso and optimized to leverage the unique features and address the limitations of 45nm CMOS and 22nm FinFET technologies. Furthermore, the study offers recommendations for selecting the appropriate technology based on specific performance criteria and application needs. The findings aim to guide future design decisions and improvements in shifter technology.
Study of Masanumasika Garbha Vikas Krama (Monthwise Devlopment during Pregnancy) in Context to Embryogenesis and Foetal Development
Authors: Gochar Dr. Asha
Published: October 2024

Sushruta Samhita is a significant Ayurvedic text on human anatomy and physiology. It provides detailed information on Garbha Vriddhi and Vikas Krama (Growth and Development) Various texts express different opinions regarding Garbha Utpatti (Fertilization) and Garbha Vriddhi. Acharyas have explained Garbhini Lakshana (Gravida symptoms) also. Which are helpful in early pregnancy diagnosis. Charaka has explained month wise symptoms in Garbhini during pregnancy. Now days, obstetrics is a fundamental field of study dealing with human reproduction, offering comprehensive information on fetal growth and development. Contemporary obstetrics has undergone extensive research and development. Neonatal mortality and fetal fatality are always the causes of concern. Samhitas provide pertinent resources on these topics. Acharyas have discussed about these in the reference of Garbhini. It takes a great deal of research and debate to comprehend the old Garbha Utpatti or Garbhavkranti notion. Examining both contemporary and Ayurvedic literature will aid in learning more about this. The goal of this study is to compare and clarify the concepts of embryogenesis from antiquity to the present
Nano antioxidant serum ethanol extract lime peel (Citrus aurantifolia S.)
Authors: Fortuna Putri Asabella , Mugiyanto Eko , Waznah Urmatul , Rahmasari Khusna Santika
Published: October 2024

Serum is a cosmetic that has received great attention from the industry, but the main challenges are appearance, transparency and public acceptance of herbal active ingredients. On the other hand, herbal cosmetics, such as those using lime peel, are also growing. This study aims to determine the antioxidant activity of lime peel made in a nano extract serum preparation. The method for making nano extracts uses ionic gelation with PSA (Particle Size Analyzer) and Zeta Potential characterization. The concentration of nano serum of lime peel ethanol extract used was 0.5%; 1%; and 3%. Meanwhile, the antioxidant activity testing method uses DPPH and data analysis applied one-way ANOVA then by Tukey test. The results of the nano extract serum formulation using organoleptic testing are transparent, thick and liquid, odorless, and feel moist on the skin. The results of nanoparticle characterization using PSA measurements with three replications were 295.1; 320.3; 385.4 nm and the results of testing the zeta potential of nanoparticles with three replications, namely 3.2; 3.4; 6.0mV. Furthermore, the results of the antioxidant activity test on the basis of the preparation formula are classified as weak (IC50 value of 156.22 μg/mL); Meanwhile, preparation formula with a concentration of 0.5%; 1%; 3% are considered very strong (IC50 value of 46.39 μg/mL; 41.06 μg/mL; 36.27 μg/mL). The results of data analysis consider significance of p value below 0.05. The conclusion is nano lime peel extract meets the requirements and the serum preparation meets the requirements and has antioxidant activity.
Formulation And Evaluation Sunflower Seed Oil With Sappan Wood Extract (Caesalpinia Sappan) Lip Balm
Authors: Anugerah Suciati  , Mutmaina Diah Ayu , Marfu’ah Nurul
Published: October 2024

Lip balm preparations can be used to prevent and treat chapped lips due to UV exposure and synthetic ingredients. Natural ingredients such as sappan wood extract and sunflower seed oil can be used to reduce the use of synthetic ingredients. The brazilin compound in sappan wood has anti-free radical, antibacterial, and anti-inflammatory abilities. While chlorogenic type polyphenol compounds in sunflower seeds have potential as antioxidants. The purpose of this study was to make a lip balm preparation of a combination of sunflower seed oil with sappan wood extract. This research is an experimental research by extracting sappan wood using the socletation method and 70% ethanol solvent. Lip balm preparations were made from a combination of sunflower seed oil: secang wood extract in the ratio of 5%:1,25% (F1), 10%:2.5% (F2) and 15%:3,75% (F3). Evaluation of the preparation includes organoleptic test, homogeneity, pH, spreadability, adhesiveness, melting point, and moisture capacity. While the results of the stability test were analyzed using the paired t-test parametric test with SPSS 24.0 and a significance level of 95%. The results showed that the characteristics of the lip balm preparation of a combination of sunflower seeds and sappan wood extract showed results in organoleptic testing, namely having a yellowish beige and yellow color. The aroma is typical of beeswax with an oily semi-solid texture. The lip balm preparation shows that all preparations are homogeneous, with pH test results of 4.90-6.12; leachability of the lip balm.
A jornada da descoberta de si: uma análise dialógica da representação da identidade bissexual na webtoon heartstopper
Authors: Silva Paulo Eduardo Ferreira da , Casado Alves Maria da Penha , Souza Matheus Silva de , Oliveira William Brenno dos Santos
Published: October 2024

As webtoons emergem na contemporaneidade como uma forma singular de expressão criativa, oferecendo um espaço vital para a representação de identidades marginalizadas. A partir disso, este artigo tem como objetivo analisar a constituição da identidade do personagem Nick na webtoon Heartstopper, considerando as marcas linguístico- discursivas que delineiam essa construção. Situado no paradigma teórico-metodológico da abordagem dialógica da linguagem, o estudo fundamenta-se nos pressupostos do enunciado concreto (Bakhtin, 2016), da palavra e do signo ideológico (Volóchinov, 2019a, 2019b, 2017), bem como em teorias de identidade e alteridade (Bakhtin, 2010; Medviédev, 2016; Sobral e Giacomelli, 2015). A análise dos dados revela a formação de uma identidade bissexual em constante processo de construção, resistente aos estereótipos social e historicamente perpetrados na sociedade. Essa representação sugere uma narrativa de identidade fluida e multifacetada, destacando a complexidade das experiências individuais e desafiando noções preconcebidas de sexualidade e gênero.
Screening for contamination with genetically modified organisms in food, feed and their additives obtained in retail and online shops in Latvia
Authors: Grantiņa-Ieviņa Lelde , Boikmanis Guntis , Ortlova Karīna , Mališevs Artjoms , Ķibilds Juris , Kovaļčuka Lilija , Miltiņa Elizabete , Jēriņa Aija , Avsejenko Jeļena , Skrebeļa Linda Laura , Zariņa Elīza , Kropačeva Līna , Bebre Evija , Rostoks Nils
Published: October 2024

The aim of the study was to screen for contamination of food and feed products with genetically modified organisms (GMO) in several sample groups obtained from retail and online shops. The total number of samples was 171, including 67 of food, 26 feed, 27 additive, and 51 samples of dried pollen for human consumption. Detection and quantification of GMO in food and feed was performed according to the approved quantitative real-time PCR methods. Fermentation product samples were analyzed using screening for antimicrobial resistance genes, 16S RNA and ITS1 sequencing, isolation of bacterial cultures and whole genome sequencing. In total, GMO contamination was found in 12 samples (in 10.45% of food and in 19.23% of feed samples). A lower proportion of GMO containing samples were from the European Union (10.26 %) vs. samples from outside (17.02%), but none with ingredients of both origins. Non-compliant were three food and five feed samples. Of the 27 samples of food and feed additives and food supplements, 10 samples were possibly non-compliant, as they contained live bacteria with antimicrobial resistance genes, and seven of them contained possibly recombinant DNA. The study indicates presence of GMO contamination that emphasizes the need for further monitoring.
Hydrothermal liquefaction: exploring feedstock for sustainable biofuel production
Authors: Mansuri Sahir Q. , Shekhawat V.P.S.
Published: October 2024

A number of technological strategies utilizing various types of biomass for the production of hydrocarbons have been put forth but their energy intensive methods are a concern for improved efficiency of biofuel production. Hydrothermal liquefaction (HTL) has emerged as a promising and feasible technology towards utilization of lignocellulosic biomass. The suitability of different biomass feedstock for HTL is intricately tied to their macromolecular composition and process parameters. The comprehensive analysis of feedstock for hydrothermal liquefaction (HTL) signal towards the immense potential of various biomass feedstock, such as corn stover, Miscanthus, pine biomass, Spirulina, sugarcane bagasse, rice bran etc. in contributing significantly to renewable energy production. The study emphasizes that the composition of biomass is critical in influencing bio-oil yield during the HTL process. Biomass components like cellulose, hemicellulose, and lignin, each play distinct roles in determining the efficiency of conversion. Specifically, feedstock with higher cellulose and hemicellulose content, such as Miscanthus and sugarcane bagasse, demonstrate superior bio-oil yields. The analysis of proximate factors affecting HTL efficiency reveals that moisture content, ash content and high heating value (HHV) are pivotal in optimizing the process. In addition to composition and physical characteristics, the article underscores the significance of growth conditions and nutrient utilization in cultivating biomass feedstock. Integrating HTL with biomass cultivation can create a sustainable, closed-loop system where nutrients from the HTL process are recycled back into cultivation. Biomass offers a renewable energy alternative, however it also poses challenges related to land use and potential competition with food production. Sustainable practices, such as utilizing agricultural and forestry residues and optimizing collection as well as storage processes, can alleviate some of these concerns. By optimizing feedstock selection, process parameters, and integrating sustainable practices, HTL can play a decisive role in advancing biofuel production and contributing to a more sustainable energy future. The interplay between biomass composition, processing efficiency, environmental impacts, and economic feasibility is essential for realizing the full potential of HTL technology in the bio-economy. The current analysis sheds light on the relationship of bio-oil yield with macromolecular components including cellulose, hemicellulose, and lignin as well as process parameters like ash content, moisture content, higher heating value, fixed carbon and volatiles. Focusing on process optimization, this study embodies a closer analysis of literature aimed at defining optimum strategies for enhancement of HTL.
The religious factor in destructive social processes (on the example of Islamism)
Authors:   Российская академия народного хозяйства и государственной службы при Президенте РФ, Москва, Россия, Алексей Валентинович Бритвин
Published: October 2024

Spiritual and cultural characteristics play a significant role in modern society. The religious factor is one of the key elements that ensure spiritual security, strengthen friendly relations between various ethnic and religious groups, and shape their self-determination. Religion is one of the driving forces of the development of civil society and even determines the degree of its intensity. Due to the increasing influence of religion on political processes, its influence is becoming extremely important for domestic and foreign policy activities, therefore, the government of any state should take into account religious specifics. The religious factor has a powerful consolidating condition in countering the development of destructive processes. At the same time, in order to satisfy personal ambitions and achieve political goals, despite the contradiction of the basic religious principles and doctrines, representatives of destructive religious trends actively use psychological methods of influence, using the faith and beliefs of their followers. The implementation of the proposed measures to ensure spiritual security in various spheres of civil society at all levels of government makes it possible to counteract destructive influences using religious beliefs. The aim of the study is to formulate the main outlines of a balanced policy in the ethno-confessional sphere and based on ideological principles that can provide conditions for agreement and unification of relations between political actors. It is precisely such ideological concepts that can act as a weighty opponent to the destructive process. In this study, methods based on rationalism, dialectics, comparative analysis, historiography were used, structural-functional and civilizational approaches were applied. The results of the research can be used in the development of conceptual documents in the field of security.
#Poshboss: An Ecological Ethnography of Digital Hustling
Authors:   , Ens Nicola
Published: October 2024

Against the backdrop of increasingly unstable jobs and labour market conditions, digital hustling has emerged as an alternative, utilising digital platforms to earn income. This dissertation is an ecological ethnographic investigation of digital hustling on various platforms, including reselling on Poshmark and creating content on social media. Departing from studies that situate work on a single platform, this dissertation investigates hustling as a constant pursuit of opportunities across multiple platforms. The findings tell a story of digital hustling through three dynamics: intensification, normalisation and migration. Intensification discusses how the resource of time becomes micro and multi-tasked. Intensification renders every minute, and even second, an opportunity for monetisation. Normalisation describes how a vast content-creation universe visibilises digital hustling, normalising it as a form of entrepreneurship in the process. Migration describes how digital hustling has a dynamic of continual movement to new arenas. Because of the unique nature of digital technology, this does not mean hustling moves as a distinct event but continually grows into new spaces, remaining where it once was. In sum, the dissertation demonstrates that digital hustling is becoming mainstream for people who were previously protected from it. The study has three main implications for the literature on hustling. Firstly, it demonstrates that hustling is connected to the conventional labour market. Secondly, it shows the ways platforms formalise hustling. Finally, it demonstrates hustling as a collective project of world-building. The study also includes three contributions to the field of platform work. Here, it demonstrates the importance of studying hustling across categories and types, including content creation, and understanding how this changes the quality of hustling. Secondly, it underlines the importance of empathy and understanding hustlers within their ecology. Finally, it questions the assumption that jobs are the answer for gig workers, instead suggesting this is conditional on the specific ecology.
The Development of Liveworksheets-Assisted Discovery Learning Model Worksheets for Improving Student’s Critical Thinking Ability
Authors: Nur Silvia Apriani  , Irfan Taufik Nurdin  , Yuliani Anik
Published: October 2024

Student Worksheets (LKS) are an interactive bridge between teachers and students, this is also related to measuring student learning outcomes. The use of worksheets affects the level of effectiveness in working on test questions. Stimulating students' cognitive critical thinking can be obtained, including from learning mathematics with the right approach method. One of the students' learning goals is to be innovative and creative in solving problems with solutions. The aim of this research is to develop a LKPD (Learner Worksheet) model of discovery learning assisted by a live worksheet to make it more effective and efficient and have the potential impact of growing students' cognitive level of critical thinking. The research method used is a design research model which is divided into two parts, namely preliminary (preliminary study and LKPD-Liveworksheet design) and formative evaluation including self-evaluation, prototyping (expert review, one-to-one, and small groups) research field tests as well revision. Research data was analyzed quantitatively and qualitatively. The research results show students' critical thinking abilities for Liveworksheet LKPD teaching materials with exponents and logarithms in the "Legal" and "Easy" categories according to experts and practitioners. The results of the research show that the LKPD developed is feasible, effective and influences students' critical thinking skills using the discovery learning model. The activities in this research have resulted in a product being developed in the form of a critical thinking worksheet using a discovery learning model assisted by a live worksheet which creates productive learning.
Atraer inversionistas extranjeros o nacionales para estimular la economía y la generación de más empleo formal en Cúcuta
Authors: Agredo-Hernández Estefanía , Delgado-Niño Adriana Lucia , Barrios Monsalve Ender José
Published: October 2024

Esta investigación tiene como objetivo analizar o atraer los nuevos inversionistas a Colombia para así generar mayor economía al país, hemos notado que sí hay mejor economía esta  reemplaza el desempleo por más empleos, lo cual genera una gran ayuda para la informalidad de Cúcuta gracias a las ZESES que es un gran apoyo para la ciudad podrán generar buenos empleos y la informalidad de esta manera  bajaría y no sería la ciudad con más informalidad en la tasas referentes de país aun siendo una zona frontera La propuesta más clara de esta investigación es cambiar  el ámbito de la informalidad  en las personas por un estilo de vida nuevo bajo la informalidad incentivando a trabajar en una empresa con sus todas cesantías y prestaciones reglamentarias que  puedan vivir de una manera más cómoda sabiendo que están trabajando de una forma más adecuada.