bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical assessment on heat transfer performance of double-layered oblique fins micro-channel heat sink with Al2O3 nanofluid
Authors: Choong Ji , Yu Kok , Abdullah Mohd
Published: April 2021

This paper demonstrates a numerical study on heat transfer characteristics of laminar flow in a double-layered oblique finned heat sink using nanofluids with Al2O3 nanoparticles. Micro-channel heat sink with primary channel width of 0.5 mm with aspect ratio of 3 is employed. Instead of having conventional straight fins, oblique fins with narrow secondary channels are used. In this numerical study, single-phase fluid model with conjugate heat transfer is considered. The numerical modeling was first validated with existing data for double-layered conventional micro-channel heat sink having water (base fluid) as the working fluid. Numerical investigations on oblique finned micro-channel heat sink were then conducted for flow rates ranging from 3 ? 10?7 to 15 ? 10?7 m3/s, equivalent to primary channel inlet velocity in between 0.2 and 1.0 m/s. It was found that double-layered oblique finned configuration yields better heat transfer performance, inferred by the lower overall thermal resistance obtained as compared with that of double-layered conventional heat sink. Employing double-layered oblique finned heat sink, the heat transfer performance could be further enhanced, by using nanoparticles that are added into water-based fluid. It is found that the reduction of overall thermal resistance is proportional to the volume fraction of nanoparticles. Using cross-flow double-layered oblique finned configuration, the largest reduction in the overall thermal resistance can reach up to 25%, by using nanofluids with 4% volume fraction of Al2O3 nanoparticles.
Prior Audit Experience and CFO Financial Reporting Aggressiveness
Authors: Condie Eric R. , Obermire Kara M. , Seidel Timothy A. , Wilkins Michael S.
Published: April 2021

In this study, we investigate the financial reporting behavior of chief financial officers (CFOs) with significant prior audit experience. Our tests indicate that, on average, CFOs who were former audit managers or partners report less aggressively than CFOs without prior audit experience. Thus, the mindset that auditors develop during their time in public accounting—which should value objective, transparent, and conservative financial reporting—appears to persist when auditors take high-level positions in industry. However, we also find that the reporting behavior of prior-auditor CFOs becomes more aggressive over time as the salience of their audit experience decays. Further, we find that audit fees are lower for clients with prior-auditor CFOs but increase as the CFOs' time away from auditing increases. Overall, our study offers important insights regarding how audit experience is associated with the financial reporting behavior of CFOs.

Data Availability: All data used are publicly available.
The State Expropriation Risk and the Pricing of Foreign Earnings
Authors: Hasan Iftekhar , Siraj Ibrahim , Tarazi Amine , Wu Qiang
Published: April 2021

We examine the pricing of U.S. multinational firms' foreign earnings in regard to their risk of expropriation and unfair treatment by the governments of the countries in which their international subsidiaries are located. Using 8,891 firm-years observations during the 2001–2013 period, we find that the value relevance of foreign earnings increases with the improvement of the protection from state expropriation risk in the subsidiary host-countries. Our results are not driven by the earnings management practice, investor distraction, country informativeness, and political and trade relationship of a foreign country with the U.S. Furthermore, our results are robust to the confounding effects of country factors, measurement error in the variable of the risk of expropriation, the influence of private contracting institutions, and endogeneity in the decision of the location of subsidiaries.

JEL Classifications: G14; H13; M14; L22.
A Comparison of Familial and Sporadic Type 1 Diabetes Among Young Patients
Authors: Karges Beate , Prinz Nicole , Placzek Kerstin , Datz Nicolin , Papsch Matthias , Strier Ursula , Agena Dirk , Bonfig Walter , Kentrup Heiner , Holl Reinhard W.
Published: April 2021

OBJECTIVE

To investigate natural course, treatment, and outcomes in familial versus sporadic type 1 diabetes.

RESEARCH DESIGN AND METHODS

In a population-based study, we compared patients with onset of type 1 diabetes before the age of 20 years who had a first-degree relative with type 1 diabetes (familial diabetes) with patients with type 1 diabetes who had no first-degree relative with type 1 diabetes (sporadic diabetes) at diagnosis and over the first 10 treatment years, using multivariable regression and proportional hazards models. Patients were identified from the Diabetes Prospective Follow-up Registry (DPV) between 1995 and 2018.

RESULTS

Of 57,371 patients with type 1 diabetes, 53,606 (93.4%) had sporadic diabetes and 3,765 (6.6%) had familial diabetes. Familial diabetes, compared with sporadic diabetes, was associated with younger age (median 7.9 vs. 9.7 years, P < 0.001), lower prevalence of ketoacidosis (11.9% vs. 20.4%, P < 0.001), and lower HbA1c levels (9.7% vs. 11.1%, P < 0.001) at onset and higher prevalence of associated autoimmune disease (16.7% vs. 13.6%, P < 0.001). Over 10 years, patients with familial diabetes, in comparison with sporadic diabetes, more often used insulin pumps (P < 0.001) and had a lower rate of severe hypoglycemia (12.97 vs. 14.44 per 100 patient-years, P < 0.001) but similar HbA1c levels (P ≥ 0.08) and ketoacidosis rates (1.85 vs. 2.06 per 100 patient-years, P = 0.11). In familial and sporadic diabetes, absence of ketoacidosis at onset predicted fewer events of severe hypoglycemia (hazard ratio [HR] 0.67, P < 0.001, and 0.91, P < 0.001, respectively) and of ketoacidosis (HR 0.64, P = 0.007, and 0.66, P < 0.001, respectively) after 10 years.

CONCLUSIONS

Familial type 1 diabetes, compared with sporadic type 1 diabetes, is characterized by earlier disease manifestation and higher autoimmune comorbidity as well as less metabolic decompensation at onset, likely related to higher disease awareness in affected families, while the course of disease is similar. These findings may have implications for the generalizability of results of diabetes prevention trials from patients with familial type 1 diabetes to patients with sporadic type 1 diabetes.
Difficult Airway Management in a Patient With Nicolaides-Baraitser Syndrome Who Had a Small Jaw and Limited Mouth Opening
Authors: Taharabaru Saori , Sato Takehito , Nishiwaki Kimitoshi
Published: April 2021

Nicolaides-Baraitser syndrome (NCBRS) is a rare congenital genetic disorder characterized by distinctive facial features similar to Treacher Collins syndrome (TCS). We report the first case of successful nasal fiberoptic intubation in a patient with NCBRS with micrognathia and limited mouth opening due to trismus. A 9-year-old girl with NCBRS and dental caries was scheduled to undergo general anesthesia for a dental extraction. Initial attempts at oral intubation using a video laryngoscope were unsuccessful. However, subsequent attempts at nasal intubation using a flexible fiberoptic scope were successful. This report highlights that patients with NCBRS may present with difficult airways to manage and intubate.
ANALISIS MANAJEMEN DAN KUALITAS MAKANAN KARYAWAN DI KYRIAD HOTEL BUMIMINANG PADANG
Authors: Syahputra Ikhsan Tri , Asnur Lise
Published: April 2021

Penelitian ini berjudul Analisis Manajemen dan Kualitas Makanan Karyawan di Kyriad Hotel Bumiminang Padang. Tujuan dari penelitian ini adalah untuk mengetahui manajemen dankualitas makanann karyawan di Kyriad Hotel Bumiminang Padang. Penelitian ini dilatar belakangi dengan adanya keluhan-keluhan karyawan yang menikmati makanan di kantin Kyriad Hotel Bumiminang Padang. Adapun keluhan yang dapat ditemukan peneliti adalah salah satunya yaitu karyawan mengatakan bahwa makanan yang dihidangkan tidak sesuai dengan menu yang telah ditetapkan oleh HRD. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan metode survey. Jumlah sampel dalam penelitian ini adalah 66 responden. Cara pengambilan sampel dengan menggunakan teknik nonprobability sampling. Jenis nonprobability sampling yang digunakan adalah sampling jenuh. Data dikumpulkan menggunakan kuisioner atau angket dengan menggunakan skala likert. Teknik analisis data dilakukan dengan menggunakan program komputer SPSS versi 20.00.Hasil penelitian ini menunjukkan bahwa: Manajemen makanan berada pada kategori tidak setuju dengan nilai persentase 28,8% yang artinya manajemen makanan di Kyriad Hotel Bumiminang Padang tidak baik dan tidak sesuai dengan harapan karyawan dan Kualitas makanan berada pada kategori setuju dengan nilai persentase 36,3% yang artinya kualitas makanan yang diberikan ke karyawan di Kyriad Hotel Bumiminang Padang sudah baik dan sesuai dengan keinginan dan harapan dari karyawan itu sendiri.Kata kunci: Manajemen, Kualitas Makanan, Kyriad Hotel Bumiminang Padang
IDENTIFIKASI TRADISI MEGIBUNG PADA UPACARA DEWA YADNYA DI DESA BESAKIH DAN PENGENALANNYA MELALUI MEDIA YOUTUBE
Authors: Susilawati Ni Ketut
Published: April 2021

ABSTRAKPenelitian ini bertujuan untuk : (1) mendeskripsikan serangkaian tradisi megibung mulai dari tahap persiapan, pengolahan hidangan, penyajian hidangan dan pelaksanaan megibung Di Desa Besakih, (2) memperkenalkan tradisi megibung di Desa Besakih melalui youtube. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan metode observasi,  wawancara, dan  dokumentasi. Instrumen penelitian mengunakan lembar observasi dan pedoman wawancara. Analisis data menggunakan teknik analisis deskriptif kualitatif. Hasil penelitian ini menunjukkan: (1) Tradisi megibung di Desa Besakih terdiri dari tahap persiapan, pengolahan hidangan, penyajian hidangan dan pelaksanaan megibung yang dilaksanakan dengan asas kekeluargaan dan gotong royong. Tahap persiapan meliputi persiapan bahan dan alat. Tahap pengolahan merupakan proses mengolah bahan makanan menjadi hidangan megibung. Hidangan yang disajikan terdiri dari nasi, olahan lawar yang meliputi lawar gecok, anyang, lawar belimbing, lawar jeruk dan lawar nangka, sate gede serta kuah trengtengan. Tahap penyajian terdiri dari gibungan yang diletakkan ditengah sele serta olahan lawar diletakkan disisi kanan dan kiri gibungan. Tahap pelaksanaan megibung, peserta duduk melingkar dengan etika tangan kanan mengadap ke gibungan dan berkhirnya acara setelah semua makanan selesai dinikmati. (2) Pengenalan tradisi megibung di Desa Besakih melaui youtube yaitu mendokumentasikan serangkaian acara megibung dengan menampilkan realita yang ada. Penggunaan teknologi menjadi fokus utama media pengenalan yaitu youtube popular  youtube untuk mengunggah video via online, sehingga dapat memberikan dampak edukasi dan pengetahuan bagi masyarakat mengenai tradisi megibung yang perlu dijaga dan dilestarikan.
MODERN EXPERIENCE OF PARENTERAL NUTRITION WITH STANDARDIZED PREPARATIONS OF INDUSTRIAL PRODUCTION IN PEDIATRIC PRACTICE: LITERATURE REVIEW
Authors: Znamenska T. , Vorobiova O. , Marushko Y.
Published: April 2021

Parenteral nutrition can save the lives of newborns and children who cannot receive adequate oral or enteral nutrition due to premature birth, functional immaturity, intestinal failure or inability to tolerate breastfeeding enterally due to congenital surgical pathology of the gastrointestinal tract, respiratory, cardiovascular and other. Pediatric patients, in particular infants with very low and extremely low birth weight, are particularly vulnerable to energy deficiency and protein restriction, which occurs immediately after birth and / or during periods of serious illness.

The aim ofthis work. Evaluate the current experience of using standardized drugs for parenteral nutrition in pharmacy and industrial production based on the analysis of the results of international clinical trials and published reviews in this regard.

Materials and methods. The results of 27 scientific publications were retrospectively analyzed with clear results of clinical randomized observations (case-control studies, prospective cohort studies, time series and retrospective data), multicenter studies, meta-analyzes and systematic reviews of the use of standardized drugs nutrition, industrial production: Numeta G13E, Numeta G16E of the company "Baxter" (USA), etc., also 1 systematic review of the management of "ready-to-use" drugs for parenteral nutrition in newborns. A review of data from scientometric Internet databases: Pub Med, UpToDate, Medscape EU, Medscape Pediatrics, etc.

Results. According to the literature, parenteral nutrition (PN) can be provided in the form of a standard mixture, currently mainly industrial production, which is designed to cover the nutritional needs of most patients of the same age group (pediatric, including neonatal) with a similar condition.

Conclusions. Standard solutions for PN can be safely used in most pediatric and neonatal patients, including preterm infants with very low birth weight, usually for the short period of time (up to 2-3 weeks) required by most children. In general, standardized parenteral nutrition should be preferred to individualized solutions in most pediatric patients and infants, including preterm infants with very low birth weight. The ready-to-use standardized industrial product has the potential to reduce the risk of infection, provide a sufficient supply of nutrients, ensure the child's growth within the expected range, is easy to use, reduces prescription errors and potentially reduces economic costs. The short- and long-term impact of its use in subsequent clinical trials should be evaluated.
World Covid-19 Vaccine Names Classification Using Neural Network Method
Authors: Nugroho Kristiawan
Published: April 2021

The Covid-19 pandemic has occurred for a year on earth. Various attempts have been made to overcome this pandemic, especially in making various types of vaccines developed around the world. The level of vaccine effectiveness in dealing with Covid-19 is one of the questions that is often asked by the public. This research is an attempt to classify the names of vaccines that have been used in various nations by using one of the robust machine learning methods, namely the Neural Network. The results showed that the Neural Network method provides the best accuracy, which is 99.9% higher than the Random Forest and Support Vector Machine(SVM) methods.
The Nearby Doctor Search Application Based on Android
Authors: Putra Steven Wisnu Cahya , Widiantoro Albertus Dwiyoga , Harnadi Bernardinus
Published: April 2021

This study aims to design the nearest doctor search application based on Android. The application is designed to find the nearest doctor and emergency room, show a list of emergency rooms and general doctor and specialists who open practice in Semarang area, and order queues online. The design of this application uses survey results to get data about application requirements. The application is designed based on the needs of the people who use the services of a private practice doctor and is expected to help the community in ordering queues to see a private practice doctor. The application was tested to 45 respondents ages 16-35 years who had tried the application 2-4 times. The test results state that application users will continue to be willing to use it if the application is easy to use and they have the device to run the application.
Designing Learning Game for Human Digestive System Based on Motion Sensors
Authors: Santoso Gregorius Alvin Raditya , Widiantoro Albertus Dwi Yoga , Sanjaya Ridwan
Published: April 2021

Nowaday rapid development of communication and information technology also influences the sector of education. The main activity in the education process is learning. Learning is a process of interaction between students and their environment, leading to better behavior changes [1].One of the learning subjects that students must learn is science. But Indonesian student’s scientific literacy is still low [2]. Students still consider science subjects difficult and boring [3]. One learning material that is classified difficult is the human digestive system [4]. Therefore a solution is needed to make interesting learning one of them by using learning media.Learning media that can be used for the solution is game based on motion sensors. By using games, students will be happy to accept the learning process. Based on a survey conducted on 30 respondents of junior high school students in the Semarang, it turns out that the game used as a human digestive system learning media is able to provide positive results. Through this game students can understand the digestive system material and more enthusiastic in learning.
Lived Experiences of End Stage Renal Disease Patients Undergoing Continuous Ambulatory Peritoneal Dialysis Therapy
Authors: 'Adhi M. Hanif Prasetya , Trisyani Yanny , Emaliyawati Etika
Published: April 2021

End stage renal disease (ESRD) is a serious chronic disease that resulted from complications of chronic renal failure and a final diagnosis that requires treatment modalities such as dialysis or continuous ambulatory peritoneal dialysis (CAPD). However, CAPD is rarely selected as renal replacement therapy by ESRD patients in Indonesia. Therefore, the phenomenon associated with patients undergoing CAPD is unclear, especially in Indonesia. The purpose of this study was to explore the lived experiences of ESRD patients undergoing CAPD therapy. The research method employed qualitative descriptive phenomenology. The participants in this study were 10 ESRD patients with CAPD. Data collection utilized semi-structured interviewed and data was analyzed using the Colaizzi approach. The result of the study was explained through 6 themes. These are: 1) Condition improved with CAPD, 2) Freedom of activity, 3) Between feeling better and bored 4) Health is increased, 5) It is sustained life, 6) Resignation to accept illness. In conclusion, the patients with CAPD felt  significant positive changes in their life and CAPD is considered life-sustaining for the participants, as the majority of the symptoms was decreased significantly. Therefore, the partisipants felt their conditions improved better. The unpleasant sides of CAPD are feeling bored. The support  of the family  is important as it  produced strength and passion for patients in undergoing CAPD.
Perceived Stigma, Psychological Response, And Nurse Coping In The Covid-19 Pandemic In Indonesia
Authors: Janitra Fitria Endah , Melastuti Erna , Yusuf Ah , Fadhilah Harif , Wibawa Yan Adi
Published: April 2021

Nurses are at the forefront of being directly involved in the care of Covid-19 patients. This can put nurses in a difficult position, especially if they had lack support from the surrounding environment. The society's negative stigma towards nurses can trigger psychological problems for them. Good coping is needed to maintain the work performance of nurses. This study aims to identify the perceived stigma, psychological response, and coping of nurses involved in caring for Covid-19 patients in Indonesia. This research was a cross-sectional study based on an electronic survey, the number of respondents was 509 nurses who came from all regions in Indonesia on 11-20 April 2020. Respondents were nurses who handled Covid-19 patients directly. The data were collected using a modified questionnaire the Berger stigma scale, DASS and Brief of Cope with a total of 27 questions. The questionnaires used have been proven valid and reliable after being tested on 30 nurses treating Covid-19 patients with a Cronbach Alpha value as follows: modified Berger Stigma Scale 0.952; modified DASS 0.928; and modified Brief of Cope 0.753. Most respondents were 26-35 years old (52.1%), female (61.5%), and worked in government-owned hospitals (48.3%). 231 respondents were stigmatized (45.4%), 274 respondents were depressed (46.2%) and 209 respondents were experienced stress (41.1%). The majority of respondents chose problem focused coping (65.8%). This study shows that some respondents feel they were stigmatized by society, but they have good coping (problem focused coping) to reduce their mental burden. Negative stigma against nurses is often difficult to avoid, support from family and colleagues was something that can ease the mental burden of nurses. Support from the government was needed to educate the public so that it does not give negative stigma to nurses and other health workers.
IMPLEMENTASI METODE TAMI OTAKA DALAM PEMBELAJARAN HAFALAN AL-QUR’AN DI TK PINTAR KOTA BANDUNG
Authors: Muhammad Sufyan As-Tsauri
Published: April 2021

The purpose of this research is to see the implementation, evaluation, and advantages and disadvantages of the Tami Otaka Method. The Tami Otaka Method is a method of memorizing by using the ability of the right brain by means of the students memorizing the Qur’an while moving their hands from the verse they are reading. The type of research taken is field research using a qualitative approach. The object of this research is TK PINTAR Bandung, which includes the principal, tahfidz teacher, curriculum, and students. To obtain research data, researcher used observation, interview, and documentation techniques. This research uses descriptive qualitative analysis, so that the results of this study are manifested in the form of words both orally and verbally. The results obtained are as follows: first, to achieve purpose of the learning, TK PINTAR Bandung uses the Tami Otaka method with the help of audio, visual, audio-visual and body movements of a teacher. Second, the curriculum used is a synthesis of the National Curriculum and the Typical Curriculum of TK PINTAR Bandung. Third, learning is carried out in groups. Fourth, the evaluation is given continuously everyday and there is also an evaluation every semester.

 

Tujuan dari penelitian ini adalah untuk mengetahui pelaksanaan, penerapan, evaluasi serta kelebihan dan kekurangan dari Metode Tami Otaka. Metode Tami Otaka adalah Metode menghafal menggunakan kemampuan otak kanan dengan cara siswa menghafal Al-Qur’an sambil menggerakkan tangan dari arti ayat yang dibaca. Jenis penelitian yang diambil adalah penelitian lapangan dengan menggunakan pendekatan kualitatif. Objek penelitian ini adalah lembaga TK PINTAR Bandung yang di dalamnya ada kepala sekolah, guru tahfidz, kurikulum, dan siswa. Untuk memperoleh data penelitian, peneliti menggunakan teknik observasi, wawancara, dan dokumentasi. Penelitian ini menggunakan analisis kualitatif deskriptif, sehingga hasil dari penelitian ini diwujudkan dalam bentuk kata-kata baik tulisan maupun lisan. Hasil penelitian diperoleh sebagai berikut: pertama, untuk mencapai tujuan pembelajaran, TK PINTAR Bandung menggunakan metode Tami Otaka dengan dibantu media auido, visual, audio-visual dan gerakan tubuh dari seorang guru. Kedua, kurikulum yang digunakan sintesis dari kurikulum Nasional dan kurikulum khas TK PINTAR Bandung. Ketiga, pembelajaran dilakukan secara berkelompok. Keempat, evaluasi diberikan terus menerus setiap harinya dan ada juga evaluasi tiap semester.
Endocrine dysfunctions during treatment of immune-checkpoint inhibitors
Authors: Inaba Hidefumi , Ariyasu Hiroyuki , Okuhira Hisako , Yamamoto Yuki , Akamatsu Hiroaki , Katsuda Masahiro , Jinnin Masatoshi , Hara Isao , Akamizu Takashi
Published: April 2021

Immune-checkpoint inhibitors (ICIs) are novel agents directed to various malignant tumors. During ICI therapy, however, immune related adverse effects (irAEs) including endocrine dysfunctions have been reported. Dysfunctions in the pituitary gland and the thyroid gland by ICI are often observed, and those in the adrenal glands and the pancreas are less frequent. Positive correlation of the prevalence of endocrine irAEs to clinical antitumor effectiveness during ICI therapy has been reported. The mechanisms of endocrine irAEs by ICI, however, remain unclear, and optimal prevention, prediction, and treatment of the irAEs are still uncertain. This review describes possible mechanisms involved in ICI-related immunity, and discusses clinical management of endocrine irAEs during ICI therapy.
Serological biomarkers of granuloma progression in sarcoidosis
Authors: Nguyen Chuyen Thi Hong , Kambe Naotomo , Ueda-Hayakawa Ikuko , Okamoto Hiroyuki
Published: April 2021

Sarcoidosis is a systemic disorder with unknown etiology and pathogenesis characterized by non-caseating granulomas, and different clinical manifestations of sarcoidosis hinder diagnosis and treatment. Therefore, a comprehensive understanding of serological markers based on clinical observations of sarcoidosis and the progression of granulomas would aid analysis in routine clinical practice. In this review, we overview common serological markers, including angiotensin converting enzyme (ACE) and lysozyme, and describe in detail new promising indices in sarcoidosis such as a T cell serological marker (soluble interleukin 2 receptor; sIL-2R) and thymus and activation-regulated chemokine (TARC/CCL17).
CAR-T Therapy for Solid Tumors: Development of New Strategies
Authors: Santos Marvin De los , Bernal Samuel D.
Published: April 2021

The recent approval of two CAR-T therapies by US Food and Drug Administration (FDA) marks a very significant development in cell-based cancer immunotherapy. This milestone was demonstrated by the effectiveness of eradicating hematologic cancers using CD19-specific CARs. The success spurred development of immune cell therapies for other cancers, especially solid tumors. The generation of novel CAR constructs for these cancer types represents a major challenge in bringing the technology ‘from-bench-to-bedside‘.In this review, we outline some new technologies we have developed to equip CAR-T cells to enhance efficiency while decreasing toxicity of CAR-T therapies in solid tumors.
A New Design and Epitopes Analysis for Recombinant Vaccine against Salmonella typhi by In silico Analysis
Authors: Bidmeshki Barzoki Tahereh , Ahadi Ali Mohammad , Ayat Hoda
Published: April 2021

Nowadays, foodborne diseases are one of the main problems of the world that infect humans due to consumption of contaminated water or food. Typhoid fever is one of the major causes of illness and death in the world caused by Salmonella typhi. Vaccination is one of the most effective approaches in order to reduction of the disease risk. The main goal of this study is designing and characterization of antigenic determinants of a fusion protein originated from S.typhi usable as an effective vaccine. In this study, the outer membrane proteins of salmonella have been considered as candidates conferring protection against typhoid. Considering the evidence, OmpA, OmpF and OmpC proteins of salmonella applied in a multivalent vaccine design. Conserved motives of these proteins were selected using the CLC software and then their extracellular regions of these peptides were identified with PRED-TMBB server. Appropriate motives were combined for design of final fusion protein. Finally epitops of designed protein with high antigenic properties were identified using BCPREDS, Ellipro, ABCpred, EpiJen, NetCTL-1.2, CTLpred, TAPpred, ProPred and VaxiJen servers. Predicted designed protein in this study reached a very high scores for antigenic indexes. Encoding Genetic construction of this fusion protein could be applied for production of the recombinant OmpA.OmpF.OmpC derived fusion protein with effective antigenic properties as a new vaccine against S.typhi. Laboratory experiments and animal challenging analyses is ongoing.
Gastrointestinal Nematode Infections in Antelopes from Morocco: A Coprological Survey
Authors: Aissa Saidi , Rachida Mimouni , Fatima Hamadi , Widade Oubrou
Published: April 2021

This study examined the gastrointestinal parasitological status of three endangered Sub-Saharan antelope species (Addax nasomaculatus, Oryx dammah, Gazella dorcas) hosted at Souss-Massa National Park in Morocco. A total of 254 faecal samples (80 samples from the addax population, 81 from the oryx population and 93 from the dorcas population) were analysed to determine the prevalence and the intensity of the parasites in host faeces (expressed as the mean EPG: egg per gram), using microscopic methods (Flotation and McMaster) and the molecular identification of parasites using PCR and sequencing of the second internal transcribed spacer region of the rDNA (ITS-2).

The prevalence results in the addax, oryx and dorcas gazelle were 43.7%, 2.4%, and 61.3%, respectively, for Nematodirus spp.; 21.2%, 12.3%, and 16.13%, respectively, for Trichuris spp.; and 36.2%, 39.5%, and 53.7%, respectively, for other, undistinguished strongylids.

The means of EPG values for parasites in addax, oryx and dorcas gazelle were 8.9, 2.4, and 61.3, respectively, for Nematodirus spp.; 4.3, 2.4, and 4.8, respectively, for Trichuris spp.; and 18.1, 16.6, and 50.1, respectively, for other undistinguished strongylids. Sequencing of the ITS-2 rDNA region of the isolated parasites allowed the identification of Camelostrongylus mentulatus and Nematodirus spathiger in these three antelope species. We can conclude that the studied antelopes are infected at tolerating levels with the first record of Camelostrongylus mentulatus and Nematodirus spathiger in those antelopes in Morocco.
Traumatic Blepharitis Including Cutanous Changes with a Clinical Appearance of Immune-Mediated Disease
Authors: Helga Kecova , Natalija Milcic-Matic , Tatjana Lazic , Sinisa Grozdanic
Published: April 2021

A four-year-old intact male Labrador retriever was presented with acute onset of ulcerative lesions around both eyes, on the mucocutaneous junctions around the muzzle and nares, and on the lateral aspects of paw pads. All lesions were symmetrical and well demarcated. The rest of ocular and systemic examination was unremarkable. The onset of lesions was acute and coincided with an episode of intense hunting in switchgrass. Similar lesions were present in another dog used in the same hunting trip. The clinical presentation was suggestive of a possible immune-mediated skin disease. However, the patient responded to systemic antibiotic treatment with full recovery without recurrence upon cessation of therapy. Traumatic origin should be included into differential diagnosis of mucocutaneous ulcerative lesions presenting as a possible immune-mediated skin disease.
Silicon Titanium Oxide Nanoparticles Can Stimulate Plant Growth and the Photosynthetic Pigments on Lettuce Crop
Authors: Mariz-Ponte Nuno , Sario Sara , Mendes Rafael J. , Correia Cristiana V. , Moutinho-Pereira José , Correia Carlos M. , Santos Conceição
Published: April 2021

Our knowledge of the bioactivity of silicon titanium oxide nanoparticles (TiSiO4 NPs) in crops is scarce, contrarily to TiO2NPs and SiO2NPs that are used in many industrial sectors, and have emerged in nanoagriculture (e.g., as pesticides or nanofertilisers). To evaluate the potential of using TiSiO4 NPs in nanoagriculture, it is necessary to characterize their potential benefits on crops and the safety doses. Here, we report for the first time the bioactivity of TiSiO4 NPs (up to 100 mg/L) in the model crop lettuce (Lactuca sativa L.) exposed for three weeks (from seeds/seedlings to pre-harvesting phase). The doses applied did not compromise the germination rate, and highly stimulated plant fresh matter. TiSiO4 NPs had beneficial effects on photochemical processes by increasing chlorophyll levels. Effects on photosynthesis are less evident but TiSiO4 NPs (100 mg/L) stimulated the photosynthetic potential, increasing Fv/Fm and ETR when compared to the 50 mg/L conditions. TiSiO4 NPs did not influence the net photosynthetic rate and other Calvin-cycle variables. Soluble sugars and starch levels were overall maintained. In general, this first report on TiSiO4 NPs bioactivity suggests that they did not have a toxic effect, and may be used to potentiate crops’ growth. Principal component analysis (PCA) also shows that despite effects on photosynthetic performance is minimal regarding the control, the 50 and 100 mg/L doses strongly differ, with the lower dose promoting mostly pigment accumulation, while the higher dose slightly stimulates Photosystem II efficiency including the electron transport rate and other gas exchange parameters.
Experimental Estimation of Wear Resistance of Polyamide Composites, Reinforced By Carbon and Glass Fibres Used in Metal-Polymer Gearings
Authors: Chernets Myron , Kindrachuk Myroslav , Kornienko Anatolii , Yurchuk Alina
Published: April 2021

The method of model triboexperimental studies to determine the basic mathematical model parameters of materials wear resistance at sliding friction is considered. The quantitative relative experimental characteristics of wear resistance of glass fibre and carbon fibre reinforced polyamide used in metal-polymer gear couple have been determined. Wear resistance functions of these functional polymeric composites have been established as the basic ones in the tribokinetic mathematical model of material wear for sliding friction conditions. Also, according to the conducted researches, wear resistance diagrams were constructed. They may be used as graphical indicators of wear resistance in the required range of specific friction forces. The dependences that connect the characteristic functions of wear resistance of these materials (obtained by the developed mathematical tribokinetic wear model) with linear wear and gearing service life are presented.
Investigating the impacts of artificial intelligence technology on technological innovation from a patent perspective
Authors: Qiu Yi-Hui , Yang Xin , Li Zong-Ze , Zhang Chiyu , Chen Shui-Xuan
Published: April 2021

Artificial intelligence (AI) technology has been widely applied in various fields in recent years. Nevertheless, no systematic study has yet been conducted on the effects of AI technology on different fields. In this study, the impacts of the latest AI technology on technological innovation in different fields were analysed and quantized systematically from a patent perspective. Moreover, trends on AI technological innovation in some fields were analysed thoroughly. We conducted this study on a dataset of patents related to AI technology. Based on the patent dataset, we carried out a statistical analysis on technology fields, which we defined and classified based on international patent classification (IPC) number. Distributions of IPC in different fields were also analysed to determine the trends on AI technological innovation. The research conclusions can provide useful information to investors and enterprises, who are interested in the state of the art concerning AI technology.
A Note on the Asymptotic Behavior of the Distribution Function of a General Sequence
Authors: Farhadian Reza , Jakimczuk Rafael
Published: April 2021

The aim of this note is to study the distribution function of certain sequences of positive integers, including, for example, Bell numbers, factorials and primorials. In fact, we establish some general asymptotic formulas in this regard. We also prove some limits that connect these sequences with the number e. Furthermore, we present a generalization of the primorial.
Gaps and preliminary perspectives concerning innovation infrastructure in the Carpathian Countries
Authors: Andrei Coca , Petruța Blaga
Published: April 2021

Innovation, although still an emerging concept in terms of development policies, is no longer abstract, being defined, measured and assessed by performance indicators, thus managing to shape the global economy and also entrepreneurial dynamics at territorial level. Using as main source of documentation the “Global Innovation Index 2020” Report, this paper seeks to highlight by using quantitative statistical methods the innovation performance of the Parties of the Carpathian Convention with a deep focus on innovation infrastructure, measured by 10 performance indicators.
A Single Institution Experience in Hypertrofic Pyloric Stenosis
Authors: Toth Tamas , Prişcă Ana-Maria , Borda Angela , Gozar Horea , Prişcă Radu-Alexandru
Published: April 2021

The most common causes of non-bilious vomiting in infants are hypertrophic pyloric stenosis and pylorospasm. Differential diagnosis between the pathologies establishes the correct treatment. The aim of our study is to present the management of the pathologies cured in our department. The longer the duration of vomiting symptoms the higher muscle thickness was shown. Dehydration and lethargy was associated with higher muscle thickness. There were no intraoperative or postoperative complications recorded in our cases. Ultrasonography is the gold standard in imaging technique but it requires an experienced radiologist. In case of negative physical examination and ultrasonography, but high suspicion of the diagnosis a fluoroscopy may be required. The correct diagnosis avoids unnecessary surgery combined with general anesthesia.
Incomplete Kawasaki Disease: What Can We Do About It?
Authors: Dobrotă Luminiţa , Cazan Corina , Bratu Dan-Vladimir , Neamţu Bogdan
Published: April 2021

Kawasaki disease is a rare condition that mainly affects children younger than 6 years old. However, it represents the most common cause of acquired heart disease and the second most frequent vasculitis in children. Its importance consists in cardiac (coronary) complications identified in adults younger than 40 years old. Early diagnosis is pivotal for preventing (or reducing) coronary aneurysms and avoiding, at least, later unnecessary surgical interventions. Full (classic, complete) Kawasaki disease is easily diagnosed, even if the symptoms are not always present at the same time and most of them are unspecific. Incomplete Kawasaki disease implies challenge, delay or misdiagnosis. “Picking it up early is a winner” – the specialists say, so that early treatment administered at the right moment can stop the inflammatory process leading to much better outcomes, consequently.
Immediate Postextractional Implant Insertion in Posterior Maxilla. Therapeutic Attitude
Authors: Dumitra Dana Elena , Nicolae Vasile
Published: April 2021

The immediate postextractional implant insertion is a specific way of surgical approach to implanto-prosthetic treatment. This article addresses the indications, advantages, and surgical techniques of immediate postextraction insertion, illustrated with a clinical case. Objectives: presentation of the indications, advantages and surgical procedure of immediate postextractional implant insertion. Materials and methods: The present study considered the presentation of a case in which we opted for the insertion of implants immediately postextractionally as a therapeutic attitude. Results and discussions: The advantages and disadvantages of this therapeutic technique were represented as follows. The advantage of this technique is given by the shortening of the time necessary to complete the treatment until the prosthetic phase, the disadvantage being represented by the insertion of the implant in positions sometimes less advantageous to the prosthesis. Also, the fact that we could not preserve the alveolar ridge, keeping the bone volume necessary to insert the implant in the best position of the prosthesis by complying with the biomechanical principles, made over time, a series of complications that occurred due to vicious insertion of the implant and non-compliance with those biomechanical principles. Conclusions: The analysis of the case as a whole, represents the main premise from which any dental treatment must be started, so that the functionality of the prosthetic and aesthetic reconstruction will have to be taken into account when we choose the best treatment option.
Participatory Planning in Post-socialist Cities: A Case Study of Riga
Authors: Akmentiņa Lita
Published: April 2021

After three decades of socio-economic and political changes, participation in urban planning is still an emerging practice in post-socialist countries. Using Riga as a case study, the research aims to explore participatory planning practices in a post-socialist urban context since 1990. Employing meta-analysis as a methodological approach to combine information from various sources, the study identifies three phases of participatory planning in Riga characterized by changes in government-led participatory planning approaches, level of participation, outcomes as well as changes in the civic sector.
Reverse Logistics Tasks Tested with Path Models Based on Data of Companies Operating in Hungary
Authors: Pónusz Mónika , Gosztonyi Márton , Kővágó Györgyi , Kozma Tímea
Published: April 2021

Our research in progress is aimed at discovering how sustainable development and reverse logistics appear in the practice of companies in Hungary. Our goal is to develop an analysis framework and test it on a Hungarian sample that examines the relationship between the elements of the reverse logistics system and logistics practices. This was tested on the available sample. In the course of observing the supply chains, we intend to focus on trends of sustainable development, with an outlook on the international practice. We pay special attention to the reverse logistics aspects of company practice, presenting the logistical processes according to the environmental challenges. The background of our analyses consists of processing the literature and conducting primer assessment.
Ephemeral Social Media Visuals and Their Picturesque Design: Interaction and User Experience in Instagram Stories
Authors: Arda Balca
Published: April 2021

This article examines the temporality of ephemeral visual posts to social media with an emphasis on Instagram stories. Drawing on theories of the spectacle, it is my contention that interaction and user-experience design, as it pertains to social media platforms, highlights the contemporary conditions and motivations in our society of abundant visual consumption. This article investigates what it means for a social media user to attend to such time-related visual experience. Throughout this piece, I critically survey the relationship between ephemeral Instagram stories’ popularity and the high speed temporality of the social media sphere with emphasis on the digital “picturesque.” Perishable daily sharing on social media reflects a contemplative glimpse into a personal lifespan presented as an object of mass appreciation. I examine how ephemerality as a component of design impacts online sociality through the picturesque visual mode. Contemporary boredom and competitive engagement in high-technological communication networks inform how we might direct digital publics to find alternative pathways to sociality.
Within the world of demicontractive mappings. In Memoriam Professor Ştefan Măruşter (1937-2017)
Authors: Berinde Vasile , Păcurar Mădălina
Published: April 2021

Professor Ştefan Măruşter, an outstanding Romanian mathematician and computer scientist, passed away on December 24th 2017. The aim of this note is to present some relevant information on his life and impressive professional activity. Most of the material included here is taken from the conference presentations [Berinde, V., In honour and celebration of the 80th birthday of Professor Ştefan Măruşter, Plenary lecture, Ceremony in honour of Professor Ştefan Măruşter’s 80th birthday, SYNASC 2017, September 23rd, 2017] and [Berinde, V., Păcurar, M., On some contributions of Professor Ştefan Măruşter to the study of demicontractive type mappings, Workshop “Iterative Approximation of Fixed Points”, SYNASC 2017, September 22nd, 2017].
Fixed Point Results for Generalized Contraction Mappings and Cyclical Mappings in b-Metric Spaces Endowed with a Digraph
Authors: Mohanta Sushanta Kumar , Biswas Deep
Published: April 2021

In this paper, we establish a fixed point theorem for generalized contraction mappings in b-metric spaces endowed with a digraph. As an application of this result, we obtain fixed points of cyclical mappings in the setting of b-metric spaces. Our results extend and generalize several existing results in the literature.
Culture of Sedentary Play in India – The Space Context
Authors: Deshmukh Amit S.
Published: April 2021

Playing of sedentary games with dice and playing board games have had a major role in the Indian culture since at least 3000 BCE. This is shown by archaeological sites and early literary references in the Rig-Veda, Mahabharata and other texts. Some of these games have survived in the form of boards, game pieces, dice and cards. Apart from actual sets, the traces of board games can also be found in Hindu rock cut temples. These sculptures and paintings appear across the medieval period. The list is exhaustive. The game play also finds its presence on numerous temple floorings, carved or inscribed. Why would somebody carve these board games on these spaces? Interestingly, throughout history, some board games have increased its popularity, and some have disappeared from artistic expressional record. How did one board game overtake the other in terms of its popularity in the later phases of history? What made these games socially acceptable and popular? Where were these games played? What was the space context? The paintings dominantly show royal houses, court rooms as spaces. Were there special pavilions used for game playing by Indian royals? In India board games were traditionally played at ground level. With growing European influence in the subcontinent in the 18th century, local elites adopted the western custom of elevated furniture for board games. Did this change the space context?

The paper thus tries to evolve parameters to analyze the impact of board games on spaces and would throw light on the “space context” with reference to Indian board games tracing it to the contemporary time.
Comparison of effect of aquatic interventions on cardiac modulation of obese young males in motion. A crossover trial
Authors: Tufekcioglu Ertan , Konukman Ferman , Arafat Samer , Almalty Abdul-Majeed , Kanniyan Abdussalam , Filiz Bijen
Published: April 2021

Study aim: The study aimed to compare the effects of passive Watsu therapy and immersion on cardiac locomotor synchronization of obese young males.

Material and methods: Twenty-six volunteer obese males participated in this study (age 18.3 ± 0.32, BMI 36.9 ± 6.52). Heart rate variability parameters were recorded in different positions by the Polar H7 heart rate sensor and HRV+ software. Participants were assigned to two groups, randomly, in a single-blinded crossover design. Kubios HRV 2.2 and MATLAB were used to analyze the bio-signals. Statistical analysis was performed via t-test and ANOVA (analysis of variance) using SPSS. For the significance in results and group comparison, the paired t-test and the independent t-test were used respectively.

Results: Combined results indicated that Watsu therapy increased 3 HRV vertical position parameters and immersion increased 3 HRV non-locomotor parameters, significantly (p < 0.05).

Conclusion: The findings show that Watsu and immersion improved the specific autonomic cardiac modulation. However, non-contact immersion seemed to provide better synchronization of cardiac control and locomotion. The close contact Watsu approach provided improvements in autonomic cardiac regulation. Collectively, these improvements suggest the combination of both therapies in maximizing the cardiac benefits sought by aquatic therapy programs.