bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Viral RNA Patterns and High Viral Load Reliably Define Oropharynx Carcinomas with Active HPV16 Involvement
Authors: Holzinger Dana , Schmitt Markus , Dyckhoff Gerhard , Benner Axel , Pawlita Michael , Bosch Franz X.
Published: March 2023

PDF file - 100K, Area under the time-dependent receiver operating characteristic (ROC) curves for overall and progression-free survival over 5 years follow-up. Curves are based on the clinical model (black) together with the viral markers (HPV16 DNA (red), viral load (green), HPV16 E6* RNA (blue), HPV16 CxCa-like RNA patterns (turquois) and HPV marker combination (purple)), with the cellular marker p16INK4a (yellow) or with the combination of p16INK4a and HPV16 DNA (gray). The horizontal line at 0.5 is included for reference corresponding to random guessing.
Supplementary Figures 1-5 from Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer
Authors: Liu Xiyong , Lai Lily , Wang Xiaochen , Xue Lijun , Leora Sofia , Wu Jun , Hu Shuya , Zhang Keqiang , Kuo Mei-Ling , Zhou Lun , Zhang Hang , Wang Yafan , Wang Yan , Zhou Bingsen , Nelson Rebecca A. , Zheng Shu , Zhang Suzhan , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Figures 1-5 from Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer
Supplementary Methods from Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis Bullosa
Authors: Ng Yi-Zhen , Pourreyron Celine , Salas-Alanis Julio C. , Dayal Jasbani H.S. , Cepeda-Valdes Rodrigo , Yan Wenfei , Wright Sheila , Chen Mei , Fine Jo-David , Hogg Fiona J. , McGrath John A. , Murrell Dedee F. , Leigh Irene M. , Lane E. Birgit , South Andrew P.
Published: March 2023

PDF file - 382K, Includes Microarray and Expression Analysis, BRB Array Clustering Analysis, and Tumorigenicity assays
Supplementary Figure 4 from Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis Bullosa
Authors: Ng Yi-Zhen , Pourreyron Celine , Salas-Alanis Julio C. , Dayal Jasbani H.S. , Cepeda-Valdes Rodrigo , Yan Wenfei , Wright Sheila , Chen Mei , Fine Jo-David , Hogg Fiona J. , McGrath John A. , Murrell Dedee F. , Leigh Irene M. , Lane E. Birgit , South Andrew P.
Published: March 2023

PDF file - 79K, A: Average array signal intensities �SD for the single probe representing COL7A1, n=3-5. B: Western blotting shows the level of type VII collagen varies between sample groups, increased in both UVSCCF samples compared with NHF. Type VII collagen is identified in RDEB fibroblast samples from patients with the following COL7A1 genotypes: x79 6501G>A/unknown and 2470insG/2470insG, and RDEBSCC fibroblasts samples from patients with x31 3832-1G>A/Unknown and x73 6075delC/unknown COL7A1 genotype.
Supplementary Figure 1 from FLT-PET Is Superior to FDG-PET for Very Early Response Prediction in NPM-ALK-Positive Lymphoma Treated with Targeted Therapy
Authors: Li Zhoulei , Graf Nicolas , Herrmann Ken , Jünger Alexandra , Aichler Michaela , Feuchtinger Annette , Baumgart Anja , Walch Axel , Peschel Christian , Schwaiger Markus , Buck Andreas , Keller Ulrich , Dechow Tobias
Published: March 2023

PDF file - 96K, FLT uptake is a sensitive measure for response to HSP90 inhibition in NPM-ALK overexpressing lymphoma cells in vitro
Supplementary Figure 1 from Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti–CTLA-4 Therapy
Authors: Waitz Rebecca , Solomon Stephen B. , Petre Elena N. , Trumble Anne E. , Fassò Marcella , Norton Larry , Allison James P.
Published: March 2023

PDf file - 198K
Supplementary Figure 5 from BRAF Inhibitor Vemurafenib Improves the Antitumor Activity of Adoptive Cell Immunotherapy
Authors: Koya Richard C. , Mok Stephen , Otte Nicholas , Blacketor Kevin J. , Comin-Anduix Begonya , Tumeh Paul C. , Minasyan Aspram , Graham Nicholas A. , Graeber Thomas G. , Chodon Thinle , Ribas Antoni
Published: March 2023

PDF file - 41K, Effects of vemurafenib on the cytotoxic effects of pmel-1 adoptive cell transfer (ACT) at a high initial dose of cells
Supplementary Figures 1-3 from Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy
Authors: Noguchi Takuro , Kato Takuma , Wang Linan , Maeda Yuka , Ikeda Hiroaki , Sato Eiichi , Knuth Alexander , Gnjatic Sacha , Ritter Gerd , Sakaguchi Shimon , Old Lloyd J. , Shiku Hiroshi , Nishikawa Hiroyoshi
Published: March 2023

PDF file - 1MB
Supplementary Table 3 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: March 2023

XLS file - 28K, Cox Proportional Hazards Model Comparing High to Low Tumor Methylation Across CpG Loci in the PcG|MIR|TFBS Class
Supplementary Figure 4 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: March 2023

PDF file - 94K, Specificity analysis for survival association with PcG|MIR|TFBS locus methylation
Supplementary Tables 1-6, Figures 1-4 from N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma
Authors: Fletcher Jamie I. , Gherardi Samuele , Murray Jayne , Burkhart Catherine A. , Russell Amanda , Valli Emanuele , Smith Janice , Oberthuer André , Ashton Lesley J. , London Wendy B. , Marshall Glenn M. , Norris Murray D. , Perini Giovanni , Haber Michelle
Published: March 2023

PDF file - 318K
Supplementary Figure 2 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: March 2023

PDF file - 455K
Supplementary Table 2 from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: March 2023

PDF file - 60K, PCR primer sequences and products size
Supplementary Methods from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: March 2023

PDF file - 79K, Includes information on Antibodies and Western Blotting, Cell Proliferation Assay, as well as RNA extraction and Reverse Transcription-PCR data
Supplementary Table 1 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 98K, List of TGF-B superfamily genes affected by CCN6 knockdown in HME cells measured by real time PCR.
Supplementary Figure Legend from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 91K.
Supplementary Figure 3 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 330K, A. rhCCN6 protein rescues the upregulation of P-p38 and the invasive phenotype due to CCN6 KD in HME cells. B. p38 kinase activity inhibitor SB203580 reversed the invasive phenotype of CCN6 KD HME cells. C. Inhibition of p38 kinase by 20 �M SB203850 or 10 �M SB202190 is sufficient to reduce invasion of SUM149 IBC cell line and aggressive MDA-MB-231 breast cancer cells.
Supplementary Figure 2 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 100K, A. Effect of CCN6 KD on P-Smad1, P-Smad5 and total proteins. CCN6 KD increased P-Smad1 while it downregulated P-Smad5. B. Immunoblot showing effective Smad1 siRNA inhibition in HME CCN6 KD and controls. β-Actin was used as loading control. Invasion assays show that Smad1 siRNA has not significant effect on invasion of CCN6 KD or control cells.
Supplementary Figure 1 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 121K, Confocal images and immunoblot analysis of HME CCN6 KD and control cells grown in 3D for 15 days. CCN6 KD led to disruption of acinar organization and decreased expression of E-cadherin protein. β-Actin was used as loading control.
Supplementary Methods from The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences
Authors: Sainz-Perez Alexander , Lim Annick , Lemercier Brigitte , Leclerc Claude
Published: March 2023

PDF file - 59K, Supplementary Methods include quantitative analysis, as well as cloning and sequencing data.
Supplementary Figure 6 from An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Authors: Cho Hye Rim , Wen He , Ryu Young Jin , An Yong Jin , Kim Hyo Cheol , Moon Woo Kyung , Han Moon Hee , Park Sunghyouk , Choi Seung Hong
Published: March 2023

PDF file - 173K, Marker metabolites for the LC group established using breast cancer cells
Supplementary Table 1 from Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis
Authors: van der Weyden Louise , Papaspyropoulos Angelos , Poulogiannis George , Rust Alistair G. , Rashid Mamunur , Adams David J. , Arends Mark J. , O'Neill Eric
Published: March 2023

PDF file - 45K, List of siRNA sequences
Supplementary Figure 2 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: March 2023

PDF file - 1.7MB, Effect of XIAP silencing by specific antisense oligonucleotide on apoptosis induction in neuroblastoma cells.
Supplementary Methods from Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7
Authors: Liu Can , Kelnar Kevin , Vlassov Alexander V. , Brown David , Wang Junchen , Tang Dean G.
Published: March 2023

PDF file - 128K
Supplementary Figure 5 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
Authors: Clegg Nicola J. , Wongvipat John , Joseph James D. , Tran Chris , Ouk Samedy , Dilhas Anna , Chen Yu , Grillot Kate , Bischoff Eric D. , Cai Ling , Aparicio Anna , Dorow Steven , Arora Vivek , Shao Gang , Qian Jing , Zhao Hong , Yang Guangbin , Cao Chunyan , Sensintaffar John , Wasielewska Teresa , Herbert Mark R. , Bonnefous Celine , Darimont Beatrice , Scher Howard I. , Smith-Jones Peter , Klang Mark , Smith Nicholas D. , De Stanchina Elisa , Wu Nian , Ouerfelli Ouathek , Rix Peter J. , Heyman Richard A. , Jung Michael E. , Sawyers Charles L. , Hager Jeffrey H.
Published: March 2023

PDF file - 483K
Supplementary Table 4 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
Authors: Aleksandrova Krasimira , Boeing Heiner , Jenab Mazda , Bueno-de-Mesquita H. Bas , Jansen Eugene , van Duijnhoven Fränzel J. B. , Rinaldi Sabina , Fedirko Veronika , Romieu Isabelle , Riboli Elio , Gunter Marc J. , Westphal Sabine , Overvad Kim , Tjønneland Anne , Halkjær Jytte , Racine Antoine , Boutron-Ruault Marie-Christine , Clavel-Chapelon Françoise , Kaaks Rudolf , Lukanova Annekatrin , Trichopoulou Antonia , Lagiou Pagona , Trichopoulos Dimitrios , Mattiello Amalia , Pala Valeria , Palli Domenico , Tumino Rosario , Vineis Paolo , Buckland Genevieve , Sánchez María-José , Amiano Pilar , Huerta José María , Barricarte Aurelio , Menéndez Virginia , Peeters Petra H. , Söderberg Stefan , Palmqvist Richard , Allen Naomi E. , Crowe Francesca L. , Khaw Kay-Tee , Wareham Nickolas , Pischon Tobias
Published: March 2023

PDF file - 100K, Relative risks (RR-s) and 95% confidence intervals (CI-s) of colon, rectal and colorectal cancer according to sex-specific quintiles of baseline leptin concentrations, in men and women , the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003
Supplementary Figure 2 from BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death
Authors: Dutta Chaitali , Day Tovah , Kopp Nadja , van Bodegom Diederik , Davids Matthew S. , Ryan Jeremy , Bird Liat , Kommajosyula Naveen , Weigert Oliver , Yoda Akinori , Fung Hua , Brown Jennifer R. , Shapiro Geoffrey I. , Letai Anthony , Weinstock David M.
Published: March 2023

PDF file - 135K, 293T cells were transfected with empty pcDNA3.1 or pcDNA3.1-HA-BCL2. After 24 hours, cells were harvested and lysates were separated into nuclear (nuc) and cytoplasmic (cyto) fractions. Western blotting was performed using indicated antibodies. Untransfected 293T, OCI-LY1 and OCI-LY8 cells were collected while in exponential culture
Supplementary Table 4 from Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Authors: Hilvo Mika , Denkert Carsten , Lehtinen Laura , Müller Berit , Brockmöller Scarlet , Seppänen-Laakso Tuulikki , Budczies Jan , Bucher Elmar , Yetukuri Laxman , Castillo Sandra , Berg Emilia , Nygren Heli , Sysi-Aho Marko , Griffin Julian L. , Fiehn Oliver , Loibl Sibylle , Richter-Ehrenstein Christiane , Radke Cornelia , Hyötyläinen Tuulia , Kallioniemi Olli , Iljin Kristiina , Orešič Matej
Published: March 2023

Supplementary Table 4 from Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Supplementary Figures 1-4 from SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase MMP-9
Authors: Cock-Rada Alicia M. , Medjkane Souhila , Janski Natacha , Yousfi Nadhir , Perichon Martine , Chaussepied Marie , Chluba Johanna , Langsley Gordon , Weitzman Jonathan B.
Published: March 2023

PDF file - 958K
Supplementary Tables 1-5 from Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer
Authors: Smith Steven C. , Baras Alexander S. , Owens Charles R. , Dancik Garrett , Theodorescu Dan
Published: March 2023

PDF file - 93K, Activity and expression of Ral paralogs in human cancer tissues and cell lines and listing of the genes composing the Ral expression signature used to stratify patients in our study
Supplementary Figure 4 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
Authors: Luo Zhongguang , Yu Guangyang , Lee Hyuk Woo , Li Lihui , Wang Lingyan , Yang Dongqin , Pan Yongfu , Ding Chan , Qian Jing , Wu Lijun , Chu Yiwei , Yi Jing , Wang Xiangdong , Sun Yi , Jeong Lak Shin , Liu Jie , Jia Lijun
Published: March 2023

PDF file - 924K, No obvious dysfunction of liver, kidney or muscle of animals was observed post MLN4924 treatment
Supplementary Figure 3 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
Authors: Luo Zhongguang , Yu Guangyang , Lee Hyuk Woo , Li Lihui , Wang Lingyan , Yang Dongqin , Pan Yongfu , Ding Chan , Qian Jing , Wu Lijun , Chu Yiwei , Yi Jing , Wang Xiangdong , Sun Yi , Jeong Lak Shin , Liu Jie , Jia Lijun
Published: March 2023

PDF file - 1MB, MLN4924 induced more apoptosis in MEF-Atg7-KO compared to MEF-Atg7-WT
Supplementary Figures 1-6 from Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer
Authors: Smith Steven C. , Baras Alexander S. , Owens Charles R. , Dancik Garrett , Theodorescu Dan
Published: March 2023

PDF file - 860K, Comparison of immunohistochemical evaluation of Ral paralog expression and mRNA Ral expression signature in human tumors as a function of patient outcome
Supplementary Methods, Figures 1 - 9, Table 1 from Small GTPase RhoE/Rnd3 Is a Critical Regulator of Notch1 Signaling
Authors: Zhu Zehua , Todorova Kristina , Lee Kevin K. , Wang Jun , Kwon Eunjeong , Kehayov Ivan , Kim Hyung-Gu , Kolev Vihren , Dotto G. Paolo , Lee Sam W. , Mandinova Anna
Published: March 2023

PDF file - 557KB, Supplementary Methods Suppl. Table 1. Primers used for real time and conventional RT-PCR . Suppl. Figure S1. RhoE expression is down-regulated in skin SCC tumors. Suppl. Figure S2. Notch activation does not induce expression of members of the Rho GTPase family of proteins. Suppl. Figure S3. Endogenous activation of Notch signaling induces the expression of Hey2. Suppl. Figure S4. Depletion of RhoE inhibits downstream Notch target genes. Suppl. Figure S5. Real-time RT-PCR analysis of mRNA isolated from primary keratinocytes. Suppl. Figure S6. Levels of RhoE and Keratin1 are increased during keratinocyte differentiation. Suppl. Figure S7. RhoE ablation suppresses growth and commitment to differentiation. Suppl. Figure S8. Negative control for RhoE and Notch1 staining in SCC4 cells. Suppl. Figure S9. Depletion of RhoE abrogates the binding between NIIC and importin Beta1.
Supplementary Figure 1 from miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
Authors: Majid Shahana , Dar Altaf A. , Saini Sharanjot , Arora Sumit , Shahryari Varahram , Zaman Mohd Saif , Chang Inik , Yamamura Soichiro , Tanaka Yuichiro , Deng Guoren , Dahiya Rajvir
Published: March 2023

PDF file - 869K, Larger pictures of Figure 1E
Supplementary Figures 1-5, Table 1 from Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling
Authors: Horst David , Chen Justina , Morikawa Teppei , Ogino Shuji , Kirchner Thomas , Shivdasani Ramesh A.
Published: March 2023

PDF file - 385K
SupplementaryTable 2 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue
Authors: Beane Jennifer , Cheng Luis , Soldi Raffaella , Zhang Xiaohui , Liu Gang , Anderlind Christina , Lenburg Marc E. , Spira Avrum , Bild Andrea H.
Published: March 2023

Excel file, 10K, Patient demographics for lung tissue samples used in biochemical validation.
Supplementary Figure 4 from Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression
Authors: Bobrie Angélique , Krumeich Sophie , Reyal Fabien , Recchi Chiara , Moita Luis F. , Seabra Miguel C. , Ostrowski Matias , Théry Clotilde
Published: March 2023

PDF file - 109K, Complete list of secreted proteins analyzed by antibody microarrays. PDF (109KB) Source File (PDF) 186KB A- Arbitrary expression level of the proteins expressed above background by 4T1 or TS/A. B-D- Scheme of the 4 antibody microarray membranes and complete list of the proteins analysed
Supplementary Figure 3 from Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression
Authors: Bobrie Angélique , Krumeich Sophie , Reyal Fabien , Recchi Chiara , Moita Luis F. , Seabra Miguel C. , Ostrowski Matias , Théry Clotilde
Published: March 2023

PDF file - 158K, Involvement of the immune system in differential growth of TS/A, 4T1, and their sh27a-expressing counterparts; A-Examples of FACS stainings and cytospin analysis of CD11b, CD11c, Ly6C and Ly6G in spleens of tumor-bearing mice. B, C- Growth of Scr- and sh27a-4T1 in Rag2-/- or CD4+ T cell-depleted hosts
Supplementary Figure 2 from Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression
Authors: Bobrie Angélique , Krumeich Sophie , Reyal Fabien , Recchi Chiara , Moita Luis F. , Seabra Miguel C. , Ostrowski Matias , Théry Clotilde
Published: March 2023

PDF file - 77K, Metastasis formation after i.v. injection and in vitro growth of 4T1; Metastasis formation by 4T1 after i.v. injection is decreased (A), whereas growth of 4T1 tumors in vitro is not affected (B) by Rab27a inhibition
Supplementary Figure 4 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Authors: Yang Eddy S. , Nowsheen Somaira , Rahman Mohammad A. , Cook Rebecca S. , Xia Fen
Published: March 2023

PDF file - 145K, Representative images of BRCA1 distribution and �H2AX foci in xenograft tissue
Supplementary Figure Legends 1-4 from Bone Marrow Stroma–Secreted Cytokines Protect JAK2V617F-Mutated Cells from the Effects of a JAK2 Inhibitor
Authors: Manshouri Taghi , Estrov Zeev , Quintás-Cardama Alfonso , Burger Jan , Zhang Ying , Livun Ana , Knez Liza , Harris David , Creighton Chad J. , Kantarjian Hagop M. , Verstovsek Srdan
Published: March 2023

Supplementary Figure Legends 1-4 from Bone Marrow Stroma–Secreted Cytokines Protect JAK2V617F-Mutated Cells from the Effects of a JAK2 Inhibitor
Supplementary Figures 1-5 from Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation
Authors: Popova Tatiana , Manié Elodie , Rieunier Guillaume , Caux-Moncoutier Virginie , Tirapo Carole , Dubois Thierry , Delattre Olivier , Sigal-Zafrani Brigitte , Bollet Marc , Longy Michel , Houdayer Claude , Sastre-Garau Xavier , Vincent-Salomon Anne , Stoppa-Lyonnet Dominique , Stern Marc-Henri
Published: March 2023

PDF file - 1.7MB, Figure S1. Near-diploid (A) and near-tetraploid (B) profiles and patterns of alteration detected with the GAP method in the series of BLCs (Affymetrix SNP6.0). Figure S2. Four outlying patterns of alteration found in the series of BLCs. Figure S3. Deciphering the cutoff for the �small-scale� variation. Figure S4. LSTs detected in SNP array profile and validated by the NGS, Sanger sequencing and translocation specific PCR. Figure S5. Translocation specific PCR for validation of inter-chromosomal translocations detected by NGS and found within LSTs boundaries.
Supplementary Methods from RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
Authors: Wang Hongyan , Liu Kaihua , Geng Miao , Gao Peng , Wu Xiaoyuan , Hai Yan , Li Yangxia , Li Yulong , Luo Lin , Hayes John D. , Wang Xiu Jun , Tang Xiuwen
Published: March 2023

PDF file - 97K, Includes plasmid construction data, GST pull-down assay, and immunoprecipitation data. Also includes supplementary references.
Supplementary Figure 7 from RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
Authors: Wang Hongyan , Liu Kaihua , Geng Miao , Gao Peng , Wu Xiaoyuan , Hai Yan , Li Yangxia , Li Yulong , Luo Lin , Hayes John D. , Wang Xiu Jun , Tang Xiuwen
Published: March 2023

PDF file - 288K, The binding of NRF2 to the ARE sites in MCF7 and MCF7-RXRo cells.
Supplementary Figure 2 from Soluble CD200 Is Critical to Engraft Chronic Lymphocytic Leukemia Cells in Immunocompromised Mice
Authors: Wong Karrie K. , Brenneman Fred , Chesney Alden , Spaner David E. , Gorczynski Reginald M.
Published: March 2023

PDF file - 181K, Comparison of CD40, CD20, CD38, and CD49d expression on CLL cells engrafted in NOD.SCIDgammacnull mice and CLL cells from original spleen: Expression of CD40, CD20, CD38, and CD49d on cells gated on human CD45 expression from Sp6 (original; upper panel) and from peritoneal cavity of mice engrafted with Sp6 for 70 days (middle and lower panel). FACS staining data from 2 representative animals are shown.
Supplementary Video 2 from Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors
Authors: Manzoor Ashley A. , Lindner Lars H. , Landon Chelsea D. , Park Ji-Young , Simnick Andrew J. , Dreher Matthew R. , Das Shiva , Hanna Gabi , Park Won , Chilkoti Ashutosh , Koning Gerben A. , ten Hagen Timo L.M. , Needham David , Dewhirst Mark W.
Published: March 2023

AVI file - 34.5MB, Real-time intravascular release of doxorubicin from Dox-TSL and subsequent redistribution of drug in B16 melanoma tumor tissue. The video shows drug (red) delivered over the first 20min, at 20x magnification. The eNOS-GFPtg mouse model was used in this experiment, so the blood vessels are green. (Download before playing in IE8)
Supplementary Figure 4 from SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression
Authors: Zhang Jianchao , Liang Qian , Lei Yang , Yao Min , Li Lili , Gao Xiaoge , Feng Jingxin , Zhang Yu , Gao Hongwen , Liu Dong-Xu , Lu Jun , Huang Baiqu
Published: March 2023

PDF file - 1.8MB, SOX4 indirectly regulated E-cadherin transcription
Supplementary Table 1 from Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer
Authors: Silva Ariosto S. , Kam Yoonseok , Khin Zayar P. , Minton Susan E. , Gillies Robert J. , Gatenby Robert A.
Published: March 2023

PDF file - 26K, Parameters used in computational model
Supplementary Figure Legend from Oxidative Stress-Regulated Lentiviral TK/GCV Gene Therapy for Lung Cancer Treatment
Authors: Leinonen Hanna M. , Ruotsalainen Anna-Kaisa , Määttä Ann-Marie , Laitinen Heidi M. , Kuosmanen Suvi M. , Kansanen Emilia , Pikkarainen Jere T. , Lappalainen Jari P. , Samaranayake Haritha , Lesch Hanna P. , Kaikkonen Minna U. , Ylä-Herttuala Seppo , Levonen Anna-Liisa
Published: March 2023

PDF file - 57K
Supplementary Figure 8 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Authors: Shoshani Ofer , Massalha Hassan , Shani Nir , Kagan Sivan , Ravid Orly , Madar Shalom , Trakhtenbrot Luba , Leshkowitz Dena , Rechavi Gideon , Zipori Dov
Published: March 2023

PDF file - 72K, Artificial tetraploidization of diploid MSCs
Supplementary Table 4 from B-Raf Activation Cooperates with PTEN Loss to Drive c-Myc Expression in Advanced Prostate Cancer
Authors: Wang Jingqiang , Kobayashi Takashi , Floc'h Nicolas , Kinkade Carolyn Waugh , Aytes Alvaro , Dankort David , Lefebvre Celine , Mitrofanova Antonina , Cardiff Robert D. , McMahon Martin , Califano Andrea , Shen Michael M. , Abate-Shen Cory
Published: March 2023

XLS file - 58K, List of differentially expressed genes between Nkx3.1CE2/+; Ptenf/f; BrafCA/+ and Nkx3.1CE2/+; Ptenf/f mouse prostate tumors (p-value<0.01)
Supplementary Figure 4 from NF-κB Activity Regulates Mesenchymal Stem Cell Accumulation at Tumor Sites
Authors: Uchibori Ryosuke , Tsukahara Tomonori , Mizuguchi Hiroyuki , Saga Yasushi , Urabe Masashi , Mizukami Hiroaki , Kume Akihiro , Ozawa Keiya
Published: March 2023

PDF file - 189K, In vivo imaging of NF-kappaB-suppressed MSC accumulation at tumor sites
Supplementary Figures 3 and 4 from Neuropilin-1–Dependent Regulation of EGF-Receptor Signaling
Authors: Rizzolio Sabrina , Rabinowicz Noa , Rainero Elena , Lanzetti Letizia , Serini Guido , Norman Jim , Neufeld Gera , Tamagnone Luca
Published: March 2023

PDF file, 161K, Suppl. Fig. 3. Nrp1 promotes cancer cell growth independently of VEGF-binding. Suppl. Fig. 4. The extracellular domain of Nrp1 promotes tumor growth in vivo.
Supplementary Figure 5 from Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells
Authors: Shien Kazuhiko , Toyooka Shinichi , Yamamoto Hiromasa , Soh Junichi , Jida Masaru , Thu Kelsie L. , Hashida Shinsuke , Maki Yuho , Ichihara Eiki , Asano Hiroaki , Tsukuda Kazunori , Takigawa Nagio , Kiura Katsuyuki , Gazdar Adi F. , Lam Wan L. , Miyoshi Shinichiro
Published: March 2023

PDF file - 61K, Protein expression changes after long-time drug-free culture.
Supplementary Figure 3 from HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair
Authors: Nowsheen Somaira , Cooper Tiffiny , Bonner James A. , LoBuglio Albert F. , Yang Eddy S.
Published: March 2023

PDF file - 62K, MCF7 HER2 cells but not its isogenic MCF7 NEO controls are susceptible to the PARP inhibitors ABT-888 and AZD-2281
Supplementary Table 4 from The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism
Authors: Chinnaiyan Prakash , Kensicki Elizabeth , Bloom Gregory , Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Eschrich Steven , Qu Xiaotao , Forsyth Peter , Gillies Robert
Published: March 2023

PDF file - 224K, Transcriptional pathways associated with metabolic pathways
Supplementary Movie 1 from β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma
Authors: Carbonell W. Shawn , DeLay Michael , Jahangiri Arman , Park Catherine C. , Aghi Manish K.
Published: March 2023

MOV file - 932K, Supplementary Movie 1. Beta1 Integrin Knockdown Impairs BRG Adhesion And Spreading. Related to Figure 2. Timelapse phase-contrast imaging of BRG3 bevacizumab-resistant cells on fibronectin demonstrates rapid adhesion and spreading of control (shCTRL, left) cells within 30 mins of plating. In contrast, significantly fewer beta1 integrin knockdown cells (shB1-c6, right) are able to adhere and spread. A subset of knockdown cells can be seen to float away due to impaired ability to adhere to the fibronectin substrate. Movie images captured with a 40x objective representing approximately 12 hours of imaging, 35 minutes between each frame.
Supplementary Table 1 from Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination
Authors: Aarntzen Erik H.J.G. , De Vries I. Jolanda M. , Lesterhuis W. Joost , Schuurhuis Danita , Jacobs Joannes F.M. , Bol Kalijn , Schreibelt Gerty , Mus Roel , De Wilt Johannes H.W. , Haanen John B.A.G. , Schadendorf Dirk , Croockewit Alexandra , Blokx Willeke A.M. , Van Rossum Michelle M. , Kwok William W. , Adema Gosse J. , Punt Cornelis J.A. , Figdor Carl G.
Published: March 2023

PDF file - 52K, Characteristics matched controls
Supplementary Table 1 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: March 2023

PDF file - 99K, Immunostaining for Pak1 and Pak2 in mouse skin
Supplementary Figure 2 from Rab25 Is a Tumor Suppressor Gene with Antiangiogenic and Anti-Invasive Activities in Esophageal Squamous Cell Carcinoma
Authors: Tong Man , Chan Kwok Wah , Bao Jessie Y.J. , Wong Kai Yau , Chen Jin-Na , Kwan Pak Shing , Tang Kwan Ho , Fu Li , Qin Yan-Ru , Lok Si , Guan Xin-Yuan , Ma Stephanie
Published: March 2023

PDF file, 720K, Detection of DNA copy number change of Rab25 by dual-color fluorescent in situ hybridization (FISH) in ESCC cell lines KYSE520, EC109 and formalin-fixed paraffin-embedded ESCC clinical tissue specimens (#1 and #2) with no or low Rab25 expression. BAC probe to Rab25 and the control reference probe to the centromere of chromosome 1 are represented by red and green signals, respectively. Magnification at 1000x.
Supplementary Figure 2 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: March 2023

PDF file - 232K, Immunohistochemical analysis of P-Erk, P-Akt, P-S6, and beta-catenin in tumors arising in K5-tTR::tet-Kras mice
Supplementary Figure 1 from Mammary Gland Selective Excision of c-Jun Identifies Its Role in mRNA Splicing
Authors: Katiyar Sanjay , Jiao Xuanmao , Addya Sankar , Ertel Adam , Covarrubias Yolanda , Rose Vanessa , Casimiro Mathew C. , Zhou Jie , Lisanti Michael P. , Nasim Talat , Fortina Paolo , Pestell Richard G.
Published: March 2023

PDF file - 183K
Supplementary Table 3 from Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family
Authors: Pouliot Lynn M. , Chen Yu-Chi , Bai Jennifer , Guha Rajarshi , Martin Scott E. , Gottesman Michael M. , Hall Matthew D.
Published: March 2023

XLS file - 59K, Results from miRNA mimic screen
Supplementary Figure 2 from Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein
Authors: Arzumanyan Alla , Sambandam Vaishnavi , Clayton Marcia M. , Choi Steve S. , Xie Guanhua , Diehl Anna Mae , Yu Dae-Yeul , Feitelson Mark A.
Published: March 2023

PDF file - 649K
Supplementary Tables 1 through 8 from Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer
Authors: Jerby Livnat , Wolf Lior , Denkert Carsten , Stein Gideon Y. , Hilvo Mika , Oresic Matej , Geiger Tamar , Ruppin Eytan
Published: March 2023

XLS file, 80K, The file includes the following tables: 1. A description of the metabolic processes utilized as input for MPA. 2. Comparison between the MPA profiles of three human tissues: liver, adipose and muscle. 3. The relation between measured lipids in BC, to the gene expression and MPA scores of de-novo lipogenesis reactions. 4. Analysis of PC(14:0,16:0): Correlation between its level and reaction expression. 5. AUCs obtained in the classification of BC samples. 6. Comparison between the MPA profiles of early and late stage tumors. 7. Comparison between the MPA profiles of ER+ and ER- tumors. 8. The top ten biomarkers predicted for metastatic BC, or only for metastatic ER+ BC.
Supplementary Figure 3 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Authors: Liu Lucy , Nam Sangkil , Tian Yan , Yang Fan , Wu Jun , Wang Yan , Scuto Anna , Polychronopoulos Panos , Magiatis Prokopios , Skaltsounis Leandros , Jove Richard
Published: March 2023

Supplementary Figure 3 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Supplementary Figure 2 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Authors: Liu Lucy , Nam Sangkil , Tian Yan , Yang Fan , Wu Jun , Wang Yan , Scuto Anna , Polychronopoulos Panos , Magiatis Prokopios , Skaltsounis Leandros , Jove Richard
Published: March 2023

Supplementary Figure 2 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Supplementary Table 1 from Densely Granulated Murine NK Cells Eradicate Large Solid Tumors
Authors: Liu Rebecca B. , Engels Boris , Arina Ainhoa , Schreiber Karin , Hyjek Elizabeth , Schietinger Andrea , Binder David C. , Butz Eric , Krausz Thomas , Rowley Donald A. , Jabri Bana , Schreiber Hans
Published: March 2023

PDF file - 55K
Supplementary Figure 4 from Densely Granulated Murine NK Cells Eradicate Large Solid Tumors
Authors: Liu Rebecca B. , Engels Boris , Arina Ainhoa , Schreiber Karin , Hyjek Elizabeth , Schietinger Andrea , Binder David C. , Butz Eric , Krausz Thomas , Rowley Donald A. , Jabri Bana , Schreiber Hans
Published: March 2023

PDF file - 52K
Supplementary Figure 2 from Densely Granulated Murine NK Cells Eradicate Large Solid Tumors
Authors: Liu Rebecca B. , Engels Boris , Arina Ainhoa , Schreiber Karin , Hyjek Elizabeth , Schietinger Andrea , Binder David C. , Butz Eric , Krausz Thomas , Rowley Donald A. , Jabri Bana , Schreiber Hans
Published: March 2023

PDF file - 185K
Supplementary Figure 1 from Densely Granulated Murine NK Cells Eradicate Large Solid Tumors
Authors: Liu Rebecca B. , Engels Boris , Arina Ainhoa , Schreiber Karin , Hyjek Elizabeth , Schietinger Andrea , Binder David C. , Butz Eric , Krausz Thomas , Rowley Donald A. , Jabri Bana , Schreiber Hans
Published: March 2023

PDF file - 36K
Supplementary Table 2 from Exploiting the Mutanome for Tumor Vaccination
Authors: Castle John C. , Kreiter Sebastian , Diekmann Jan , Löwer Martin , van de Roemer Niels , de Graaf Jos , Selmi Abderraouf , Diken Mustafa , Boegel Sebastian , Paret Claudia , Koslowski Michael , Kuhn Andreas N. , Britten Cedrik M. , Huber Christoph , Türeci Özlem , Sahin Ugur
Published: March 2023

XLS file - 56K
Supplementary Table 1 from Exploiting the Mutanome for Tumor Vaccination
Authors: Castle John C. , Kreiter Sebastian , Diekmann Jan , Löwer Martin , van de Roemer Niels , de Graaf Jos , Selmi Abderraouf , Diken Mustafa , Boegel Sebastian , Paret Claudia , Koslowski Michael , Kuhn Andreas N. , Britten Cedrik M. , Huber Christoph , Türeci Özlem , Sahin Ugur
Published: March 2023

XLS file - 15K
Supplementary Figure 2 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

PDF file - 140K, FP/obatoclax down-regulates Bcl-xL, but not Bcl-2, which plays a partial role in this regimen
Supplementary Figure 7 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: March 2023

PDF file - 522K, RAD18 is not required for RAD51 assembly at DSB sites in the absence of BRCA1 and 53BP1
Supplementary Figure 8 from Cardiac Inflammation after Local Irradiation Is Influenced by the Kallikrein-Kinin System
Authors: Sridharan Vijayalakshmi , Tripathi Preeti , Sharma Sunil K. , Moros Eduardo G. , Corry Peter M. , Lieblong Benjamin J. , Kaschina Elena , Unger Thomas , Thöne-Reineke Christa , Hauer-Jensen Martin , Boerma Marjan
Published: March 2023

PDF file - 163K, Western-Blot analysis of c-Jun at 3 months after sham-irradiation or local heart irradiation with 24 Gy
Supplementary Figure 4 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: March 2023

PDF file - 217K, Cell cycle analysis
Supplementary Table S4 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: March 2023

Supplementary Table S4 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Table 1 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 322K, Pten-/-Ink4a/Arf-/-mNSCs induced gliomas. Intracranial Pten-/-Ink4a/Arf-/-mNSCs injected mice generated different tumor phenotypes with different survivals. II: WHO Grade II astrocytoma; III: WHO Grade III astrocytoma; IV: WHO Grade IV astrocytoma (GBM).
Supplementary Figure 8 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: March 2023

PDF file - 383K, Proposed CCSC hierarchy in CAC
Supplementary Figure 6 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: March 2023

PDF file - 1214K, Levels of expression of HIF-1 target genes in tumors inoculated with bone marrow Gr1+ cells or NEMs. Quantification of the mRNA levels of the indicated factors (VEGF-A, Angiopoietin-2 and Interleukin-6) was obtained by real-time PCR. The results are shown after normalization for the GAPDH gene. Data are mean �s.e.m. **=P<0.01; *=P<0.05.
Supplementary Figure 5 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: March 2023

PDF file - 3704K, The vessel normalization effect of NEMs is independent of tumor size. B16.F10 tumors were inoculated in mice, which were then injected at days 11 and 13 after tumor inoculation with PBS, Gr1+ cells and NEMs. Mice were sacrificed when tumors reached 1700 mm3 , irrespective of the day. A. Immunofluorescence analysis of the vasculature - representative images. Frozen sections were stained with antibodies against CD31 (green) and α-SMA (red).Nuclei are counterstained with DAPI. Scale bar: 100 μm. B. Quantitative evaluation of the α-SMA/CD31 ratio in vessels of tumors injected with PBS, Gr1+ cells or NEMs. Data are mean�s.e.m. **=P<0.01 vs. PBS.
Supplementary Figure 3 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: March 2023

PDF file - 1471K, Levels of expression of plexins in CD11b+ Gr1+ Nrp1+ cells and in NEMs. Real-time PCR quantifications were normalized to the levels of GAPDH mRNA. Data are mean �s.e.m. **=P<0.01; *=P<0.05.
Supplementary Figure 1 from Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy
Authors: Maas Amanda L. , Carter Shirron L. , Wileyto E. Paul , Miller Joann , Yuan Min , Yu Guoqiang , Durham Amy C. , Busch Theresa M.
Published: March 2023

PDF file - 4.7MB
Supplementary Figures 1-12 from The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss
Authors: Feng Yan , Wang Ye , Wang Zuoyun , Fang Zhaoyuan , Li Fei , Gao Yijun , Liu Hongyan , Xiao Tian , Li Fuming , Zhou Yang , Zhai Qiwei , Liu Xiaolong , Sun Yihua , Bardeesy Nabeel , Wong Kwok-kin , Chen Haiquan , Xiong Zhi-qi , Ji Hongbin
Published: March 2023

PDF file - 307K, Supplementary Figure S1. Ectopic NEDD9 expression partially reverses the inhibitory function of LKB1 upon cell migration and invasion of human lung cancer cells. Supplementary Figure S2. shNedd9 inhibits lung cancer progression in de novo KrasG12D, Lkb1L/L mouse model. Supplementary Figure S3. NEDD9 promotes lung cancer progression in de novo KrasG12D mouse model. Supplementary Figure S4. LKB1 specifically regulates CRE-Luc activity. Supplementary Figure S5. shCRTC1 down-regulates NEDD9 mRNA expression. Supplementary Figure S6. Screening for the responsive element of CRTC1/CREB on NEDD9 promoter. Supplementary Figure S7. LKB1 regulates NEDD9 promoter activity through the non-classical CRE site. Supplementary Figure S8. Immunofluorescence assay showed that ectopic Flag-LKB1 expression promoted SIK2 translocation into nucleus in A549 cells. Supplementary Figure S9. Immunofluorescence assay showed that LKB1 knockdown promoted SIK2 translocation into cytoplasm while CRTC1 translocation into nucleus in CRL-5866 cells. Supplementary Figure S10. SIK2 knockdown up-regulates NEDD9 mRNA expression via promoting CRTC1 nuclear translocation. Supplementary Figure S11. Ectopic CRTC1 expression partially reverses the inhibitory function of LKB1 upon cell migration and invasion of human lung cancer cells. Supplementary Figure S12. NEDD9 immunostaining in human lung cancer specimens
Supplementary Methods, Figure Legends 1-5, Table 1 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: March 2023

PDF file - 133K
Supplementary Figure 5 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: March 2023

PDF file - 160K, ER� increase PR activity. MDA-MB-231 cells were stably transfected with human PRB (pSG5-PRB) or with the empty vector (pSG5) and different clones were obtained. The expression of PRB was evaluated by Western blot (A), using T47D cells as a positive control of hormone receptors, or by immunofluorescence (B, bar: 30�m). (C) MDA-MB-231 pSG5 clone (3) and pSG5-PRB clone (1) cells were transiently transfected with human ER� (pSG5-HEGO) and its expression was evaluated by immnunofluorescence. Bar: 15�m. (D) MDA-MB-231 pSG5 clone (3) and pSG5-PRB clone (1) cells were co-transfected with ER� and PRE-Luc vectors. After 24 h starvation in 1% chFCS, cells were incubated with MPA for another 24 h and the activity of luciferase was evaluated.
Supplementary Figure 4 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: March 2023

PDF file - 3.3MB, Expression of CCND1 and MYC proteins after MPA treatment. T47D cells were starved in 1% chFCS and incubated with MPA (10nM) for different times. Total protein extracts were used in Western blot assays to evaluate the expression of CCND1 and MYC. Erk1/2 was used as loading control. A representative experiment of three (left) is shown together with the quantification of the bands respect to the loading control (right).