bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Lego Games on Improving Children’s Creativity Development
Authors: Id'ha Tutfi Ulkhatiata  , Purnama Sigit
Published: June 2024

Purpose – This study aims to determine the effect of the lego game on lego games in increasing the development of creativity in children aged 4-5 years at TK Aisyiyah ABA Konang Glagah Lamongan. Following the problems found in the field, the lack of learning the media used by teachers results in children feeling bored more quickly in carrying out teaching and learning activities and only emphasizing their academic development so that the development of creativity is not given enough attention.Design/methods/approach – This type of research uses a quantitative approach with a pre-experimental type and a  one-group pretest-posttest design in collecting the data, namely making initial observations before being given treatment, treatment, and final observations after being given treatment. Data collection techniques used observation and documentation; data analysis used IBM SPSS with paired samples t-test. In this research, researchers conducted data mining using research instruments on children aged 4-5 years in TK Aisyiyah ABA Konang Glagah Lamongan.Findings – The results of the study show that the influence of the use of lego games increases the development of children’s creativity—the output of the paired sample t-test evidence this A significant value is obtained, namely 0.008 < 0.05. It indicates that H0 is rejected and Ha is accepted, meaning that there is a significant influence on increasing the development of children’s creativity using lego games.Research implications/limitations – This research only focuses on children aged 4-5 years with a limited number of 15 whose area is only in TK Aisyiyah ABA Konang Glagah Lamongan and in this study only uses lego games as a medium to increase the development of creativity in children.Practical implications – The results of this study are expected to help parents understand the creative talents possessed by children so that they can stimulate this development with the right strategies and methods.Originality/value – This research provides an in-depth understanding of one of the early childhood learning media to enhance creativity development using lego game media.Paper type: Research paper
Taurine Improved Autism-Like Behaviours and Defective Neurogenesis of the Hippocampus in BTBR Mice through the PTEN/mTOR/AKT Signalling Pathway
Authors: Xiaoyan Huang , Zhaoxi Yang , Lingli Zhang , Jinyuan Chen , Wen Qin
Published: June 2024

Effective treatment of patients with autism spectrum disorder (ASD) is still absent so far. Taurine exhibits therapeutic effects towards the autism-like behaviour in ASD model animals. Here, we determined the mechanism of taurine effect on hippocampal neurogenesis in genetically inbred BTBR T+ tf/J (BTBR) mice, a proposed model of ASD. In this ASD mouse model, we explored the effect of oral taurine supplementation on ASD-like behaviours in an open field test, elevated plus maze, marble burying test, self-grooming test, and three-chamber test. The mice were divided into four groups of normal controls (WT) and models (BTBR), who did or did not receive 6-week taurine supplementation in water (WT, WT+ Taurine, BTBR, and BTBR+Taurine). Neurogenesis-related effects were determined by Ki67 immunofluorescence staining. Western blot analysis was performed to detect the expression of phosphatase and tensin homologue deleted from chromosome 10 (PTEN)/mTOR/AKT pathway-associated proteins. Our results showed that taurine improved the autism-like behaviour, increased the proliferation of hippocampal cells, promoted PTEN expression, and reduced phosphorylation of mTOR and AKT in hippocampal tissue of the BTBR mice. In conclusion, taurine reduced the autism-like behaviour in partially inherited autism model mice, which may be associa­ted with improving the defective neural precursor cell proliferation and enhancing the PTEN-associated pathway in hippocampal tissue.
Gallic Acid Alleviates Psoriasis Keratinization and Inflammation by Regulating BRD4 Expression
Authors: Zhang Li , Ye Qiaoyuan , Gan Saiyang , Liu Huan , Zhang Qing , Wang Shuangshuang , Cheng Can
Published: June 2024

Psoriasis is a chronic non-contagious autoimmune disease. Gallic acid is a natural compound with potential health benefits, including antioxidant, anticancer, antiviral and antibacterial properties. Nevertheless, the influence of gallic acid on psoriasis has not been fully determined. This investigation aimed to discover the effect of gallic acid on psoriasis. Thirty-one pairs of psoriatic skin tissues and healthy adult human skin tissues were collected. Human keratinocytes (HaCaT cells) were transfected with interleukin 17A (IL-17A) to create the psoriatic keratinocyte model. The content of bromodomain-containing protein 4 (BRD4) microRNA was assessed using qRT-PCR testing. The content of BRD4 was detected by Western blotting. Cell migration was evaluated by conducting a wound healing assay. Cell proliferation was determined using an EdU assay. Apoptosis was detected by the TUNEL assay. The contents of interferon gamma (IFN-γ), IL-6, IL-8 and IL-17 were detected by ELISA. BRD4 was up-regulated in psoriatic skin tissues and in the IL-17A group compared to the healthy adult human skin tissues and the control group. Silencing BRD4 inhibited cell migration, proliferation and inflammatory response but induced apoptosis in IL-17A-treated HaCaT cells. Conversely, BRD4 over-expression promoted cell migration, proliferation and inflammatory response but suppressed apoptosis in IL-17A-treated HaCaT cells. Gallic acid repressed cell migration, proliferation and inflammatory response but indu­ced apoptosis in HaCaT cells transfected with IL-17A by down-regulating BRD4. Gallic acid represses cell migration, proliferation and inflammatory response but induces apoptosis in IL-17A-transfected HaCaT cells by down-regulating BRD4.
O império quebradiço. Decadência urbana e declínio físico-moral em Pranto de Maria Parda (1522) de Gil Vicente e na poesia de Gregório de Matos
Authors: Radlwimmer Romana
Published: June 2024

A partir do fim do século XV, Portugal compreende-se como uma potência mundial. No entanto, as literaturas da época apontam para a fragilidade do status imperial. Sem rejeitar completamente as lógicas dominantes, as literaturas sublinham a decadência e a destruição deixadas pelo império. Em Pranto de Maria Parda (1522), de Gil Vicente, as crises internas de Portugal tornam-se evidentes, enquanto a poesia de Gregório de Matos enfatiza as crises que a colonização incita a nível global. Os dois poetas retratam o espaço urbano — Lisboa e Salvador da Bahia — como lugar de desintegração imperial.
Evaluation of the systemic-immune inflammation index (SII) and systemic immune-inflammation response index (SIRI) in children with type 1 diabetes mellitus and its relationship with cumulative glycemic exposure
Authors: Ozde Sukriye , Akture Gulsah , Ozel Mehmet Ali , Yavuzyilmaz Fatma , Arslanoglu Ilknur , Ozde Cem , Kayapinar Osman , Coskun Gokhan
Published: June 2024

Objectives

In this study, the systemic proinflammatory status was assessed using the systemic immune-inflammation index (SII) and SIRI systemic immune-inflammatory response index (SIRI) in children and adolescents with type 1 diabetes mellitus (T1DM).

Methods

The study involved 159 patients aged between 6 and 16 years. The SII and SIRI values were calculated based on the complete blood count. Basic blood biochemistry evaluated, and carotid intima-media thickness (cIMT) was measured and recorded. The cumulative glycemic exposure was calculated by multiplying the value above the normal reference range of the HbA1c value. The sum of all these values obtained from the time of diagnosis to obtain the cumulative glycemic exposure. All findings were compared statistically. All statistically significant parameters were evaluated in the multivariate logistic regression analysis.

Results

The analysis revealed that only cIMT (Exp(B)/OR: 0.769, 95 % CI: 0.694–0.853, p<0.001), high-density lipoprotein (Exp(B)/OR: 3.924, 95 % CI: 2.335–6.596, p<0.001), monocyte count (Exp(B)/OR: 1.650, 95 % CI: 1.257–2.178, p<0.001), hematocrit (Exp(B)/OR: 0.675, 95 % CI: 0.523–0.870, p<0.001), and SIRI (Exp(B)/OR: 1.005, 95 % CI: 1.002–1.008, p<0.001) were significantly associated with T1DM. A statistically significant positive association was found between cumulative glycemic exposure and SIRI only (r=0.213, p=0.032). To our knowledge, this is the first study to evaluate SII and SIRI in children with type 1 diabetes.

Conclusions

These findings indicate that SIRI could serve as a potential biomarker for detecting early-onset proatherosclerotic processes in diabetic children. However, further clinical studies are required to confirm this.
Entangled photon-pair generation in nonlinear thin-films
Authors: Santos Elkin A. , Weissflog Maximilian A. , Pertsch Thomas , Setzpfandt Frank , Saravi Sina
Published: June 2024

We develop a fully vectorial and non-paraxial formalism to describe spontaneous parametric down-conversion in nonlinear thin films. The formalism is capable of treating slabs with a sub-wavelength thickness, describe the associated Fabry–Pérot effects, and even treat absorptive nonlinear materials. With this formalism, we perform an in-depth study of the dynamics of entangled photon-pair generation in nonlinear thin films, to provide a needed theoretical understanding for such systems that have recently attracted much experimental attention as sources of photon pairs. As an important example, we study the far-field radiation properties of photon pairs generated from a high-refractive-index nonlinear thin-film with zinc-blende structure that is deposited on a linear low-refractive-index substrate. In particular, we study the thickness-dependent effect of Fabry–Pérot interferences on the far-field radiation pattern of the photon pairs. We also pay special attention to study of entanglement generation, and find the conditions under which maximally polarization-entangled photon pairs can be generated and detected in such nonlinear thin-films.
Inclined magnetized infinite shear rate viscosity of non-Newtonian tetra hybrid nanofluid in stenosed artery with non-uniform heat sink/source
Authors: Al-Kouz Wael , Owhaib Wahib , Souayeh Basma , Sabir Zulqurnain
Published: June 2024

Many scholars performed the analysis by using the non-Newtonian fluids based on the nano and hybrid nano particles in blood arteries to investigate the heat transport for cure in several diseases. These performances are presented to investigate the blood flow behaviour with extended form of the novel tetra hybrid Das and Tiwari nanofluid system attached by the Carreau fluid. The assessment of energy transport has been achieved based on the thermal radiation, heat source/sink, Joule heating, and viscous dissipation. The obtained partial differential equation from physical problem is transformed into ordinary differential equations (ODEs) by using the similarity variables. Furthermore, system of nonlinear ODEs attached with boundary conditions are transported into the system of first-order ODEs with initial conditions. For the numerical solution of obtained ODEs, the numerical solutions have been performed based on the RK method. The numerical results are plotted through figures, tables, and statistical graphs. Magnetic forces and inclined magnetic effects are caused to reduce velocity of blood. Temperature of blood within the arteries is increased by increasing the parameter of thermal radiation.
Numerical modelling of large elasto-plastic multi-material deformations on Eulerian grids
Authors: Wang Lujie , Menshov Igor S. , Serezhkin Alexey A.
Published: June 2024

The paper deals with an Eulerian model for heterogeneous multiphase (multi-material) elasto-plastic media based on the diffuse interface method in the one-dimensional uniaxial strain approximation. In this approximation, an equilibrium hypoelastic Wilkins bi-material model is derived. This is carried out on the basis of an analogy between the elasto-plastic Wilkins and hydrodynamic Euler models. For the obtained model, a Godunov-type numerical method is developed based on the approximate Riemann solver HLLC. The results of the proposed Eulerian diffuse interface model are compared with reference solutions on moving grids with explicit tracking interfaces. It is shown that the present diffuse interface numerical model describes with good accuracy strong shock-wave processes in heterogeneous multiphase elasto-plastic media.
OKTATÁS HATÁRDIMENZIÓI
Authors: Megyesi Erzsébet
Published: June 2024

Az oktatás határdimenzióit több szempontból vizsgálhatjuk – többek között kiemelten a felnőttkori tanulás intézményi vonulatát, résztvevői aspektusát, gazdasági és munkaerőpiaci vetületét vagy akár társadalmi mobilitásra gyakorolt hatásait figyelembe véve. Aziskolarendszeren kívüli felnőttképzés esetében határdimenzióként tekinthetünk a felnőttek iskolai végzettségére is, mint a részvételt alapvetően meghatározó tényezőre. Jelen tanulmányban a felnőttkori iskolarendszeren kívüli tanulás változásai kerültek vizsgálatra, nagyságrendileg az elmúlt két évtizedet felölelve, kiemelten a tanuláshoz való hozzáférés, bemeneti feltételek szempontjából történő elemzésén keresztül. A kutatási céljai között szerepelt a jogszabályi környezet változása által generált új körülmények hatásainak bemutatása a felnőttek tanulási lehetőségeire, statisztikai adatok és tartalmi szabályzók elemzésével. A hipotézisek szerint egyrészt a legfeljebb alapfokú iskolai végzettséggel rendelkező felnőttek iskolarendszeren kívüli tanulási lehetőségei szűkültek, másrészt a tanulási lehetőség a szakmaszerzés esetében a jogszabályi előírások miatt is korlátozott. A tanulmány célja a 2000-es évek elejétől végig kísérni a demográfiai adatok oktatási vetülete mellett a felnőttképzés jellemzőinek főbb változásait és felhívni a figyelmet az adott célcsoportot érintő sajátosságokra.
KEZDŐ SZAKÉRTŐK ÉS SZAKÉRTŐ KEZDŐK.
Authors: Mrázik Julianna
Published: June 2024

Berliner (Berliner, 2005) szerint a szakértői tudás sokrétű fogalom, amely nemcsak a tudásra és a készségekre, hanem azok hatékony alkalmazására is kiterjed. Megkülönbözteti a szakértőket és a kezdőket, és rámutat, hogy a szakértők mélyebb tudással rendelkeznek a szakterületükről, képesek gyorsan felismerni és reagálni az információkban rejlő mintázatokra, és tudásukat hatékonyan felhasználni a döntéshozatalban. A szakértőség fogalma sokszor intuitív, túlságosan szigorú beleértési kritérium alkalmazása nem is célravezető (Anderson et al. 2023) A kezdők kevésbé jártasak a szakterületen, és nehezebbenismerik fel a releváns információkban rejlő mintázatokat. Gyakran egyszerű szabályokra vagy heurisztikákra támaszkodnak a döntéshozatal során, a mélyebb alapelvek helyett. A tanári fejlődés heurisztikus modelljében (Berliner, 2001) Berliner szakít azzal a hagyománnyal, hogy a szakértelmet a pályán eltöltött idő hossza, a diplomaszerzés óta eltelt idő vagy az életkor határozza meg. Olyan más szempontok is felmerülnek, mint a megélt esetek száma, a reflektivitás, a szakmai énkép, és -szocializáció kérdései. E szakértői modell alapján pilotkutatást végeztünk, abból a célból, hogy a korai pályaszocializáció segíti vagy hátráltatja-e a tanári pályára felkészülést. A kutatói kérdés, hogy a korai, az elsőéves tanári felkészítés első heteiben megvalósuló pályaszocializációs gyakorlat, tapasztalat, milyen hatással van a résztvevők önhatékonyság-érzésére? A vizsgálat nullhipotézise, hogy a megkérdezettek önmagáról tett állítása nem esik egybe a Berliner-féle modell behatárolással. A kutatás stratégiája kvantitatív, az adatok kigyűjtése online kérdőívvel történt, az adatok feldolgozását Jamovi 1.8 Cloud Beta platformon végeztük. A vizsgálatban résztevők száma 32 fő, a mintavételezés módja kényelmi. A pilotkutatás várható eredménye, hogy jósló erejű információt kapunk a korai pályaszocializációban résztvevő hallgatók önhatékonyságának szubjektív megítéléséről, amely a kutatás további folytatása lehetséges irányait is kijelölheti. Emellett az eredmények jól hasznosíthatóak a tanári felkészítés tartalmai fejlesztésében, egyaránt.
PROPUESTA DE RESTAURACIÓN EN LAS CUEVAS DE LOS REYES DE JUÁREZ, PUEBLA; UNA OPORTUNIDAD PARA EL TURISMO
Authors: Rojas Barranco A. , Juárez Galindo L. , Ramírez-Pacheco D. M.
Published: June 2024

En la actualidad, el estado de Puebla enfrenta desafíos importantes en cuanto al cuidado y protección de sus áreas verdes, las cuales desempeñan un papel crucial en la preservación del medio ambiente y la mitigación del cambio climático. Sin embargo, la conciencia sobre estos temas y la disposición para actuar son limitadas entre la población. Esta problemática se encuentra en Los Reyes de Juárez, un municipio del estado de Puebl, reconocido por sus campos agrícolas y sus cuevas milenarias, que son atractivos turísticos. A pesar de esto, la imagen del municipio se ve afectada por la falta de mantenimiento de sus áreas verdes. Por ello, se plantea un proyecto que propone estrategias para restaurar estos espacios y aprovechar el potencial turístico de las cuevas milenarias.
European air quality in view of the WHO 2021 guideline levels: Effect of emission reductions on air pollution exposure
Authors: Franke Philipp , Lange Anne Caroline , Steffens Brendan , Pozzer Andrea , Wahner Andreas , Kiendler-Scharr Astrid
Published: June 2024

Although anthropogenic emissions have decreased during the last 2 decades, air pollution is still problematic in Europe. This study analyzes the air quality in Europe using simulations by EURopean Air pollution Dispersion—Inverse Model for the year 2016 with updated emissions in view of the annual guideline levels for particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) released in 2021 by the World Health Organization (WHO). Three different emission scenarios are applied, including a scenario for the committed emission reductions from the European Union (EU), a scenario including additional reductions to specifically mitigate PM2.5, and a scenario in which all anthropogenic emissions are eliminated. Model results show that in Europe, the concentrations of PM2.5 and NO2 exceed the annual WHO guideline levels by up to a factor of 5.6 and 5.2, respectively, in the main polluted regions and by up to a factor of 2 for O3 in Southern Europe. High concentrations of PM2.5 and O3 are homogeneously distributed across Europe with 99% and 100% of the European population exposed to concentrations above the WHO guideline levels, respectively. NO2 concentrations above the annual WHO guideline level are primarily found in populated areas, affecting 323 million inhabitants in 2016. Although the emission scenario designed to mitigate PM2.5 shows a decrease of the highest annual mean concentrations of PM2.5 from 28 µgm−3 to 12 µgm−3, 527 million European inhabitants remain affected by PM2.5 annual mean concentrations above the WHO guideline level. Seasonal mean O3 concentrations after eliminating all anthropogenic emissions (between 60 and 82 µgm−3) are found to be above the WHO guideline level for the entire European continent. The mortality attributable to air pollution is reduced by 47% in the emission scenario for committed emissions by the EU. In the more aggressive scenario designed to mitigate PM2.5, the mortality is reduced by 72%. The study reveals that the emission scenarios and, therefore, the reduction in premature deaths are subject to sectoral emission reductions between 41% and 79%.
Research of the Values of Modern Youth as a Guidance for Preparing Student Groups Curators for Educational Activities
Authors:   Russian State Pedagogical University named after A. I. Herzen, Matrosova Yulia S. , Suvorova Svetlana A. ,   Russian State Pedagogical University named after A. I. Herzen
Published: June 2024

Introduction. The organization of educational activities in the process of vocational education is one of the pressing open issues for modern pedagogical science. Active educational practices and forms of educational work become effective if their implementation is based on a serious study of the values of students as representatives of modern youth. Methodology. The article provides an overview of research into the value orientations of young people, presents a description of students’ opinions about traditional values, and presents the results of an analysis of a survey of 3,000 students about patriotic values, carried out during the project “Student communities as a space for patriotic education”. Results. The article shows how the values of young people can be taken into account when organizing educational work. Using the example of the design and implementation of a training program for student group curators, the areas of activity that can become the most significant and effective in working with young people are presented. Conclusion. In conclusion, the authors note that it is important for curators in their activities to think over the forms of pedagogical support for studentsʼ activities, competently build a system in the educational process that unites students of different faculties, analyze the problems of student life, monitor the dynamics of studentsʼ attitudes to what is happening, and change their value attitude.
Reconstructive surgery after distal fibular resection due to bone tumors: a technical report on surgical strategies and results from the PROSPERO international register of systematic reviews
Authors: Angelini Andrea , Bohacek Ivan , Plecko Mihovil , Biz Carlo , Trovarelli Giulia , Cerchiaro Mariachiara , Di Rubbo Giuseppe , Ruggieri Pietro
Published: June 2024

Purpose

Primary bone tumors of the fibula are rare. Distal fibular resection has a significant impact on ankle biomechanics and gait, possibly leading to complications such as ankle instability, valgus deformity, and degenerative changes. Question: Is there a need for reconstructive surgery after distal fibular resection, and what reconstructive procedures are available?

Materials and methods

The review is registered with the PROSPERO International Register of Systematic Reviews. Inclusion criteria consisted of all levels of evidence, human studies, patients of all ages and genders, publication in English, and resection of the distal portion of the fibula due to tumor pathology. The reviewers defined four different categories of interest by method of treatment. Additional articles of interest during full-text review were also added.

Results

The initial search resulted with a total of 2958 records. After screening, a total of 50 articles were included in the study. Articles were divided into ‘No reconstruction’, ‘Soft tissue reconstruction’, ‘Bone and soft tissue reconstruction’, and ‘Arthrodesis, arthroplasty or other reconstruction options’ groups.

Conclusion

Limb salvage surgery should be followed by reconstruction in order to avoid complications. Soft tissue reconstructions should always be considered to stabilize the joint after fibular resection. Bone reconstruction with reversed vascularized fibula is the preferred technique in young patients and in cases of bone defects more than 3 cm, while arthrodesis should be considered in adult patients. Whenever possible for oncologic reason, if a residual peroneal malleolus could be preserved, we prefer augmentation with a sliding ipsilateral fibular graft.
Meta-analysis of the clinical efficacy and safety of single versus dual plate in the treatment of comminuted distal femur fractures
Authors: Zhang Guo-xu , Li Ji , Xie Qi-jun , Zhang Mei-ren , Zhao Kui , Chen Hai-yun
Published: June 2024

Objective

Through meta-analysis, this study aims to comprehensively evaluate the efficacy of single-plating and double-plating in the treatment of comminuted fractures of the distal femur.

Methods

Computer searches of PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), VIP, and Wanfang digital journals were performed, and the timeframe for the searches was from the establishment of each database to July 2023 for each of the databases. Meta-analysis was performed using RevMan 5.4 software provided by the Cochrane Library, and the review process was registered in the PROSPERO database.

Results

A total of ten studies were included for statistical analysis. One randomised controlled study and nine retrospective cohort studies with a total of 563 patients were included. The double-plate group was superior to the single-plate group in terms of knee mobility at 6 months postoperatively, overall postoperative complications, and the rate of healing of knee deformity. However, it increased the operation time and intraoperative bleeding, and the difference between the two groups was statistically significant (P < 0.05). There was no significant difference between the two groups in terms of excellent knee function rate, fracture healing time, plate fracture, postoperative infection, delayed fracture healing, and non-union (P ≥ 0.05).

Conclusion

Double plate fixation for comminuted fractures of the distal femur can improve knee mobility at 6 months postoperatively, reduce overall postoperative complications, and decrease the incidence of malunion healing. However, it increases operative time and bleeding. Randomised studies are needed to provide strong evidence in the future.
Vandetanib in locally advanced or metastatic differentiated thyroid cancer refractory to radioiodine therapy
Authors: Brose Marcia S , Capdevila Jaume , Elisei Rossella , Bastholt Lars , Führer-Sakel Dagmar , Leboulleux Sophie , Sugitani Iwao , Taylor Matthew H , Wang Zhuoying , Wirth Lori J , Worden Francis P , Bernard John , Caferra Paolo , Colzani Raffaella M , Liu Shiguang , Schlumberger Martin
Published: June 2024

The VERIFY study aimed to determine the efficacy of vandetanib in patients with differentiated thyroid cancer (DTC) that is either locally advanced or metastatic and refractory to radioiodine (RAI) therapy. Specifically, VERIFY is a randomized, double-blind, multicenter phase III trial aimed to determine the efficacy and safety of vandetanib in tyrosine kinase inhibitor-naive patients with locally advanced or metastatic RAI-refractory DTC with documented progression (NCT01876784). Patients were randomized 1:1 to vandetanib or placebo. The primary endpoint was progression-free survival (PFS). Secondary endpoints included best objective response rate, overall survival (OS), safety, and tolerability. Patients continued to receive randomized treatment until disease progression or for as long as they were receiving clinical benefit unless criteria for treatment discontinuation were met. Following randomization, 117 patients received vandetanib, and 118 patients received a placebo. Median PFS was 10.0 months in the vandetanib group and 5.7 months in the placebo group (hazard ratio: 0.75; 95% CI: 0.55–1.03; P = 0.080). OS was not significantly different between treatment arms. Common Terminology Criteria for Adverse Events (CTCAE) of grade ≥3 were reported in 55.6% of patients in the vandetanib arm and 25.4% in the placebo arm. Thirty-three deaths (28.2%; one related to study treatment) occurred in the vandetanib arm compared with 16 deaths (13.6%; two related to treatment) in the placebo arm. No statistically significant improvement was observed in PFS in treatment versus placebo in patients with locally advanced or metastatic, RAI-refractory DTC. Moreover, active treatment was associated with more adverse events and more deaths than placebo, though the difference in OS was not statistically significant.
Invisibles. Envejecimiento, vejez y comunidad LGBT+
Authors: Torres Alonso Eduardo
Published: June 2024

De acuerdo con el enfoque del curso de vida, el envejecimiento y la vejez humana son procesos dinámicos, responden a las interacciones del sujeto con su entorno y a los estímulos que recibe del mismo. La vejez no aparece repentinamente, sino que se va construyendo a lo largo de la vida. En este sentido, vivir un envejecimiento acompañado resulta importante para el sujeto. No obstante, las personas integrantes de la comunidad LGBT+ enfrentan dificultades durante este proceso y al llegar a la vejez están expuestas a violencias y discriminaciones no solo por su identidad sexo-genérica u orientación sexual, sino por su edad. Este rechazo a la vejez o a lo viejo, no solo ocurre entre heterosexuales, también se verifica en grupos LGBT+.
Acciones en la producción de Manihot esculenta aplicando técnicas agroecológicas para el consumo familiar
Authors: Camacaro Rojas Fátima del Rosario
Published: June 2024

La presente investigación asume que el saber pedagógico y docente es un constructo humano teórico y práctico, el cual está implícito en las acciones cotidianas que emergen de la práctica educativa realizada. Aproximarse al objeto de estudio, desde una realidad múltiple, en la investigación cualitativa, permite al investigador construir el plano teórico-conceptual de la problemática, conocer la perspectiva de quien investiga, es decir, es un proceso ref lexivo del investigador, incorporando sus vivencias y situaciones observadas en distintos contextos. Esta estrategia teórico epistemológica es diferente al diseño lineal de la investigación cuantitativa que consiste en plantear, formular y delimitar un problema de investigación. El estudio se abordará para diseñar acciones en la producción de yuca (Manihot esculenta) aplicando técnicas agroecológicas para el consumo familiar. Se ubica en línea de investigación: saberes colectivos y educación popular. Enmarcado en el ámbito de la investigación cualitativa, aplicando el socio crítico. Se aplica la metodología investigación acción participativa (IAP). A estos elementos, primero se realiza un diagnóstico participativo comunitario, la información se recauda mediante la observación participante, grupos de discusión y círculos reflexivos, y será sometida a un proceso de categorización, análisis e interpretación de la información y será también validada por medio de la triangulación. Luego se diseña el plan de acción para ser aplicado en el momento pertinente.
Archival materials of V. F. Odoevsky at the Russian national museum of music
Authors: Shevtsova Olga
Published: June 2024

This article is dedicated to the materials of the archives of Prince V. F. Odoevsky, a remarkable Russian musician-researcher, author of the first publications on the theory of znamenny chant. Talking about the manuscripts of V. F. Odoevsky, the author dwells in more detail on those that are in the Russian National Museum of Music and makes a general overview of the fund and its history. The collection of V.F. Odoyevsky's RNMM includes the Prince's musical compositions, materials for the study of folk songs and church hymns, theoretical works on harmony, acoustics, Odoyevsky's letters, notebooks, bills, receipts, photographic materials, handwritten notes from Odoyevsky's library, printed materials and programs, as well as literary manuscripts and other materials by various authors. In general, most of the completed works on Old Russian art by V.F. Odoevsky have been published. A huge number of different drafts and excerpts often represent different versions of the same works. The article goes on to describe the manuscript "Russian Ancient Church Hymn" (f. 73 No. 219), it was not completed by Odoevsky and was not published. It touches on most of the provisions expressed by Odoevsky in published articles, in particular, articles for the Archaeological Congress in Moscow.
The problem of embodiment of the liturgical text in the sacred music of A. D. Kastalsky (using the example of troparia)
Authors: Kurova Anna , Starostina Tatyana
Published: June 2024

The article is devoted to the methods of musical representation of the content of the liturgical text in the spiritual choral music of A. D. Kastalsky. The creative path of this outstanding musician, his aesthetic views, the main features of the composer's style have been largely studied by now. However, the methods of Kastalsky's refraction of the theological aspects of chants in Russian musicology have not yet been purposefully studied. This article aims to consider specific methods of musical embodiment of liturgical texts in Kastalsky's choral compositions. His polyphonic adaptations of several Znamenny chant troparia are used as material.The methodological base of the presented article is multi-component. The authors are guided by the original analytical technique of Prot. Michael Fortunato, to some extent refract the analytical experience of Prot. Sergius Pravdolyubov. The main methodological basis is the concepts developed by the musical scientists of the scientific school of the Moscow Conservatory - A.N. Myasoedov, V.V. Protopopov, Yu.N. Kholopov and their followers. In particular, the concept of tonal states is widely invoked.The analysis of selected znamenny arrangements of tropar chants includes several aspects, such as: slogo-rhythmic modeling of a verbal text; reduction of the melodic structure of Znamenny chants and understanding of their logic depending on the verbal content; clarification of the relationship of textural, timbre and harmonic features with significant fragments of the text. The authors come to the conclusion that Kastalsky is constantly striving for coloristic, sonant marking of all essential images of the liturgical text, and thereby creates an emotionally rich "translation" of the ancient monodic chant into the modern language of full-sounding polyphony.
The church-singing art of Mari region in the late 19th — early 20th centuries
Authors: Simakova Albina
Published: June 2024

This article attempts to explore a little-known topic related to the history of church singing in the Mari Region. The relevance of the above problem is beyond doubt, since this topic has not yet become the object of close attention from researchers. Studying it allows you to find out a number of important questions about the history of the Mari region. This is the Christianization of the Mari region, the church singing culture of the Mari, the state of affairs in the church singing of the Russian Orthodox Church during this period, and the emergence of the Mari intelligentsia, etc.The art of church singing in the Mari Region was of great importance and influenced not only the processes of Christianization and education of the Mari people, but also the culture, mentality and the very quality of life of local residents. The end of the sixth – the beginning of the twentieth century were very fruitful in this sense. At this time, the foundation was formed, which during the years of persecution of the Church will reveal to the world new martyrs and confessors of the Orthodox faith among local clergy, monks, laypeople, as well as regents, psalmists and choristers. The traditions of the church-singing art laid down in the pre-revolutionary period of time have not been completely lost, their development continues along with the revival of spiritual life, temples and monasteries in the Mari Region.
ENHANCING EDUCATIONAL EFFICIENCY THROUGH DATA ENVELOPMENT ANALYSIS A CASE STUDY OF THE UNIVERSITY CENTRE OF MAGHNIA-ALGERIA
Authors: BENLEBBAD Mohammed
Published: June 2024

Efficiency is a fundamental concept that involves achieving more with fewer resources. In the field of education, efficiency means using fewer or even limited resources to achieve the desired learning outcomes. Yet, measuring education efficiency is a complex task that requires the use of appropriate methods. One such method is Data Envelopment Analysis (DEA), a nonparametric technique that has been widely used in various fields, including education, health, and banking. This system is based on research operations that can provide users with strategies to achieve optimal efficiency.
The aim of this study is to use DEA to calculate the efficiency of the University Centre of Maghnia during the COVID-19 period through comparing the different institutes within this centre. The use of DEA in this study provides an opportunity for decision-makers to strategize effectively and avoid unnecessary costs.
The results of the study indicate that two Decision-Making Units (DMUs), namely the master's level in law and the bachelor's level in technology sciences, do not operate at perfect efficiency. Through the use of data analysis, the study identifies the necessary changes to achieve complete efficiency. The DMUs used for comparison are the master's level in Economics, Arabic Languages and Literature, and master of Technology.
The study revealed that the average efficiency in the input orientation was 94%, while the output orientation was 92%, assuming various returns to scale. These findings suggest that there is room for improvement in the efficiency of the University Centre of Maghnia.
Antroponimia polska na Kresach południowo-wschodnich w XIX wieku – źródła i perspektywa badawcza
Authors: MYTNIK Irena
Published: June 2024

Przedmiotem artykułu jest imiennictwo Polaków na Kresach południowo-wschodnich w XIX wieku, a celem nakreślenie perspektywy badawczej danych zawartych w aktach parafialnych i księgach status ani- marum diecezji łuckiej opublikowanych oraz pozostających w zasobach archiwalnych. Objętość materiału empirycznego to kilkadziesiąt tysięcy jednostek antroponimicznych. Omówienie uwzględnia stan badań, przegląd źródeł rękopiśmiennych i drukowanych, kontekst historyczny, szczegółowe zadania analityczne, dotyczące opisu i interpretacji lingwistycznej, przyjęte rozwiązania metodologiczne oraz znaczenie planowanych badań dla studiów onomastycznych, leksykologicznych, nad dziedzictwem kulturowym, historią Kościoła rzymskokatolickiego i obecnością etnosu polskiego na Ukrainie.

Perspektywa badawcza dotyczy studiów historyczno-etymologicznych nazwisk i opracowania monograficznego polskiego systemu antroponimicznego, ze szczególnym uwzględnieniem zasobu imion mężczyzn i kobiet w różnych warstwach społecznych oraz ich charakterystyki morfologicznej, a także formacji poimiennych chłopów, mieszczan i szlachty, ich typologii i struktury słowotwórczej, charakteru odzwierciedlonych w nich interferencji międzyjęzykowych, jak również sposobów nominacji i ich związku z dokumentami źródłowymi. Bazę teoretyczno-metodologiczną stanowić będą założenia onomastyki diachronicznej, socjolingwistyki, lingwokulturologii i językoznawstwa kognitywnego, z uwzględnieniem metod frekwencyjnostatystycznych i porównawczych, a także ujęcia geograficznego.

Otrzymane wyniki pokażą obraz antroponimii polskiej diecezji łuckiej w ostatnim etapie kształtowania się systemu nazewniczego, jego związek z antroponimią polsko-wschodniosłowiańskiego pogranicza bliż-szego, ziem etnicznych i specyfikę regionalną uwarunkowaną polsko-ukraińskimi kontaktami międzyetnicznymi, a także zakodowany w nim system wartości.

Planowane badania będą uzupełnieniem studiów dotyczących polskiego imiennictwa na Kresach południowo-wschodnich, w szczególności na terenie dawnego województwa wołyńskiego i części zabużańskiej ziemi chełmskiej (starostwo ratneńskie i lubomelskie), które były objęte jurysdykcją diecezji łuckiej, stanowić będą niezbędną podstawę do dalszych prac nad stworzeniem syntetycznego obrazu antroponimii Polaków różnych stanów na całym obszarze dawnej Ukrainy.
Physical and Chemical Characteristics of Green Algae Halimeda opuntia Calcium Powder Extracted Using Hydrochloric Acid
Authors: Wijayanti, Ph.D Ima , Nirwasita Rania S. , Anggo Apri D.
Published: June 2024

Halimeda opuntia is one of the macroalgae species whose utilization is still slightly known. In the open sea, H. opuntia holds an important role in changing carbon dioxide (CO2) to calcium carbonate (CaCO3). This led to previous research analyzing the calcium content of H. opuntia, which showed 30.30%. However, the information about calcium powder extraction using HCl from H. opuntia has not been reported. This research aimed to observe the physical and chemical characteristics of calcium obtained from H. opuntia extracted using different hydrochloric acid (HCl) concentrations. The method used in this research was experimental laboratories with a completely randomized design (CRD) using different HCl concentrations (1N, 2N, and 3N). The extraction results were analyzed for yield value, moisture, ash, fat, protein, carbohydrate, calcium, color, Scanning Electron Microscope (SEM), particle size, and X-Ray Diffraction (XRD). Data were then analyzed using Analysis of Variance (ANOVA). The use of different HCl concentrations showed significant effect (p0.05) on ash content (91.95±0.47%), carbohydrate content (7.26±0.57%), lightness (L*) (86.21±0.83), yellowness or blueness (b*) (8.81±0.02), E (11.33±0.54), and whiteness index (WI) (83.62±0.70%), where the calcium extracted by 1N HCl (CH1) showed the best result. The SEM microstructural analysis showed a non-porous surface and a single cubical shape in CH1. Diffractogram pattern of calcium extracted from H. opuntia using different concentrations of HCl done by XRD exhibited the same pattern as CaCO3 for all samples. HCl solvent at 1 N can produce calcium powder from H. opuntia with high calcium content and better color characteristics.
Cabbage Rules
Authors: Murrell Di
Published: June 2024

A short, reflective essay about food memories and what conjures them.
A Poet on the Road
Authors: Grigorieva Alexandra
Published: June 2024

Looks at letters written by Pushkin following gastronomic travelogue is unique testimony of life on the road for gentlemen of ease in provincial Russia of that time. Local gastronomic specialities seem to have coexisted with international ones in perfect harmony, although of course it should be remembered that it was the number-one road in the country, the one travelled by the crème de la crème all the time because it connected the two cities of utmost importance, Moscow and Saint-Petersburg, the past and the present capitals of Russia.
Ronnie Scott: Salad Days
Authors: Santich Barbara
Published: June 2024

Ronnie Scott: Salad Days: Penguin (Australia), 2014: 45 pp., p’back, $Aus9.99.
Comparative Analysis of Internal Tapered Implant-Abutment Connections: Evaluating the Morse Effect
Authors: Nogueira Barbosa Marchon Renata , Mourão Carlos Fernando , Rutkowski James L. , Ghanaati Shahram , Mello-Machado Rafael Coutinho , Mendes Senna Plinio
Published: June 2024

The purpose of the present study was to evaluate the Morse effect of different internal tapered implant-abutment connections (ITCs) using a pullout test. Implants with different ITCs were selected: Short (Bicon, USA), G1; Novo Colosso (Medens, Brazil), G2; Epkut (SIN, Brazil), G3; Strong SW (SIN, Brazil), G4; Flash (Conexão, Brazil), G5 and Bone Level (Straumann, Switzerland), G6. The respective computer-aided design (CAD) files were loaded into the analysis software to measure each ITC’s taper angle and implant-abutment contact area. Six implants from each group were embedded in acrylic resin blocks, and the respective universal abutments were fixed using a mallet (G1) or by applying 20 Ncm of torque (G2 to G6). After 10 minutes, each abutment’s retention screw was removed, and the force necessary for abutment rupture was recorded using a universal testing machine at a crosshead speed of 0.5 mm/min. The groups were compared using a one-way analysis of variance and Tukey’s test. Spearman’s correlation was used to check the correlation of the taper angle and contacting area with the pullout strength. G1, a no-screw abutment with a 3° taper, and G2, a 10° tapered abutment tightened by 20 Ncm, presented the highest pullout strength (P < .05). The increased taper angle of G4, compared to G3, reduced the Morse effect despite their similar implant-abutment contacting areas (P < .05). The G5 and G6 abutments loosened after screw removal and did not exhibit pullout resistance. The closer the tapered angle (r = −.958) and the higher the implant-abutment contact area (r = .880), the higher the pullout strength (P < .001). Within the limits of this study, the Morse effect is different among tapered implant-abutment connections. The closer the tapered angle and the higher the interface area, the higher the Morse effect between the abutment and the implant.
Through the Lens of the ICJ: Bridging the Gap between Human Rights and Humanitarian Norms in Global Child Soldiering
Authors: Govender Nikita
Published: June 2024

Recently in June 2022, the United Nations Special Representative of the Secretary-General for Children and Armed Conflict expressed that the ongoing use and recruitment of children in armed conflict globally warrants "international concern". Notwithstanding the existence of proscriptive norms in terms of international humanitarian law (IHL) and international human rights law (IHRL), international legal violations are nevertheless committed by states and non-state actors. A systematic analysis of the respective normative systems identifies a lacuna between specific provisions thereof. Consequently, violations are committed in armed conflicts for the purposes of IHRL but not IHL, it is contended that this inconsistency in the law perpetuates ongoing child soldiering. It is further contended that this inconsistency establishes a genus of children who are legally unprotected as they fall between the cracks of international law.
Based on recent progressive jurisprudence of the International Court of Justice, an approach which will bridge the lacuna between these norms is proposed. Contrary to the view of the International Committee of the Red Cross and with due consideration for the lex specialis principle, it is proposed that the IHL and IHRL instruments should apply in a complementary fashion, as opposed to the separate legal regimes under which they have developed.
Electrochemical impedance of porous tantalum solids: modeling of frequency response
Authors: Syugaev Alexander V. , Porsev Vitaly E.
Published: June 2024

The paper proposes a new approach to the analysis of electrochemical impedance spectra of porous tantalum bodies, which involves modeling the frequency response via an equivalent circuit that takes into account the pore hierarchy. It was shown that the proposed circuit describes well the experimental data and allows characterization of the porous structure, including the contribution of different types of pores to the total capacitance of the porous body, characteristic relaxation times, and activation frequencies for different type pores. Two types of samples were analyzed: a porous tantalum body obtained by sintering Ta powder and a porous tantalum body covered with a Ta2O5 dielectric layer. Modeling showed a significant redistribution of contributions from pores of different types into the total capacitance after the formation of Ta2O5 due tothe preferential isolation of the smallest pores and/or those difficult to access. The results of modeling of the frequency response of the analyzed samples agree well with the scanning electron microscopy data. The proposed approach has the potential to be advantageous for the technology of tantalum capacitors