bluuebunny/crossref_metadata_2025 huggingface dataset:
Utility of fusion biopsy for choosing prostate cancer patients eligible for focal therapy
Authors: Romanov R. A. , Koryakin A. V. , Kirpatovskiy V. I. , Alekseev B. Ya.
Published: August 2022

Background. Focal therapies for prostate cancer (PCa) can preserve the quality of life; however, their application is limited by lack of confidence in identifying the exact tumor location.

Aim. To evaluate the utility of fusion biopsy for choosing PCa patients eligible for focal therapy with subsequent confirmation by the analysis of radical prostatectomy (RPE) samples.

Materials and methods. This study included 122 patients with histologically verified stage Т1–2N0M0 PCa treated in N.A. Lopatkin Research Institute of Urology and Interventional Radiology, a branch of the National Medical Research Radiology Center. Their mean age was 65.2 ± 6.8 years. All patients underwent multiparametric magnetic resonance imaging and fusion biopsy (samples were collected from targeted areas in combination with a standard biopsy), followed by histological examination of biopsy samples and mapping of the affected areas. Twenty-eight patient underwent RPE.

Results. Study participants were distributed as follows by their Prostate Imaging Reporting and Data System (PI-RADS) score: 5 points in 23 patients (18.9 %), 4 points in 57 patients (46.7 %), and 3 points in 42 patients (34.4 %). Targeted biopsy revealed cancer in 105 out of 122 patients (86.1 %) in at least one sample. Seventeen targeted biopsy samples were negative. The majority of patients had ISUP (International Society of Urological Pathology) grade 1 (n = 57; 46.8 %) and grade 2 (n = 33; 27.0 %) tumors. Comparison of biopsy findings and results of pathological examination of the removed prostate demonstrated significant discrepancies in the distribution of cases by their ISUP grades. Almost half of the patients (46.8 %) were diagnosed with ISUP grade 1 tumors after biopsy, while the assessment of RPE specimen demonstrated ISUP grade 1 tumors only in 21.4 % of patients. ISUP grade 3 tumors were diagnosed in 16.4 % and 35.7 % of patients using biopsy- and RPE-derived specimens, respectively. The proportions of ISUP grade 2, 4, and 5 tumors were similar with both methods. In 27 out of 28 cases, examination of biopsy- and RPE-derived specimens demonstrated complete agreement in terms of tumor location. Importantly, this study included only patients with histologically confirmed PCa; so we didn’t evaluate the effectiveness of biopsy for cancer diagnosis. Focal therapy could have been considered in 22 out of 28 patients (78.6 %) who underwent RPE. This proportion of focal therapy-eligible patients is almost equal to that identified by fusion biopsy (75.4 %).

Conclusion. Multiparametric magnetic resonance imaging in combination with targeted and multifocal prostate biopsy allow precise identification of candidates eligible for focal therapy with a relatively low risk of an erroneous conclusion.
Pelvic lymphadenectomy for radical prostatectomy: perioperative and oncological results
Authors: Popov S. V. , Guseynov R. G. , Orlov I. N. , Skryabin O. N. , Perepelitsa V. V. , Katunin А. S. , Mirzabekov M. M. , Zaytsev A. S. , Yasheva S. Yu.
Published: August 2022

Background. Currently, in men suffering from prostate cancer, histological examination of the material obtained during pelvic lymphadenectomy (PLAE) is the most accurate and reliable method for staging the tumor process and postoperative prognosis of disease outcomes, an important factor influencing the choice of the most rational treatment tactics after radical prostatectomy. However, today questions about the therapeutic (oncological) expediency of PLAE and its safety in terms of the development of intra- and postoperative complications remain debatable.

Aim. To was to compare the perioperative and therapeutic (oncological) results of radical prostat ectomy performed in combination with standard or extended PLAE.

Materials and methods. The study materials were the data of medical records of 812 men aged 43 to 78 years, at different times (from January 2009 to December 2018) who were hospitalized for localized or locally advanced prostate cancer in stages cT1a–cT3bN0M0. The research method was a retrospective analysis of the data contained in the selected medical records.

Results and conclusion. The results of our studies, firstly, confirm the conclusions of the European Association of Urology (EAU) experts on the justification and necessity of performing an extended PLAE with radical prostatectomy in order to diagnose metastatic lesions of the pelvic lymph nodes in individuals with an intermediate or high risk of prostate cancer progression; secondly, they indicate a higher therapeutic efficacy of extended PLAE compared to that for standard PLAE, which is expressed in a statistically significantly three times lower incidence of biochemical relapses and an 11.4 % longer relapse-free period after extended PLAE than after standard PLAE. Extended PLAE, performed in one surgical session with radical prostatectomy, is not a risk factor for the development of various intra- and postoperative complications, with the exception of the lymphocele, which is formed in 3.7–13.5 % of cases of extended PLAE due to intraoperative transection of lymphatic vessels and lymph accumulation at the site of the removed adipose tissue.
Bladder neck-sparing retropubic radical prostatectomy: assessing risk factors for detection of positive surgical margins
Authors: Belousov I. I. , Kogan M. I. , Tokhtamishyan S. K. , Chibichyan M. B.
Published: August 2022

Background. Bladder neck preservation during retropubic radical prostatectomy (rRP) promotes a protective effect on urinary continence compared to standard rRP.

Aim. To assessment of possible predictors for positive surgical margin (PSM) recognition is an important step.

Materials and methods. 136 patients with localized prostate cancer (PCa) were studied in the study. Group 1, 90 patients (retrospective assessment), underwent standard rRP, group 2, 46 patients (prospective assessment), underwent rRP modified by bladder neck preservation with a part of the proximal prostatic urethra. The clinical and pathological stages of PCa were assessed; the groups were compared to the parameter PSM. Statistical analysis was performed using nonparametric statistical methods.

Results. Both groups were comparable in age and baseline total prostate specific antigen (PSA) but differed in prostate volume and Gleason score. Also, there were differences in clinical and pathological stages of PCa. PSM-patients had more aggressive PCa according to the International Society of Urological Pathology (ISUP) and TNM classifications and had higher progression risk prognosis stages. In PSM-patients, correlations were determined between prostate volume and baseline Gleason index (r = 0.338; p >0.05); baseline total PSA and Gleason score before (r = 0.529; p >0.05) and after (r = 0.310; p >0.05) rRP, respectively. Nevertheless, the incidence of PSM among all subjects was 6.6 % of cases, while in groups 1 and 2 was 7.8 and 4.3 % of cases, respectively. In this way, surgical techniques that maximize bladder neck preservation with a part of proximal prostatic urethra have no significant effect on PSM. Ranges of total PSA, clinical stage of PCa, Gleason score and progression risk stages (prognostic group for PCa) were determined as predictors of PSM. Their use will make it possible to establish patient selection criteria for bladder neck preservation with proximal prostatic urethra during rRP.

Conclusion. The identified predictors will allow determining during clinical staging minimal risks of detecting PSM. The rRP modified by bladder neck preservation with part of the proximal prostatic urethra does not increase the incidence of PSM compared to the standard rRP. The feasibility of this technique should be related to total PSA, clinical stage of PCa, Gleason score, and the progression risk stage.
IMPLEMENTATION OF ELECTRONIC ADMINISTRATIVE JUDICIAL PROCEDURE IN UKRAINE: PREREQUISITES, ESSENCE AND STAGES OF ESTABLISHMENT
Authors:   Yaroslav Mudryi National Law University, Piatyhora Kristina
Published: August 2022

The purpose of this article is to reveal the essence and content of the concept of “electronic court”, to determine the preconditions for the formation of electronic administrative proceedings in Ukraine, to analyze the main stages of formation and development of “electronic court” in administrative proceedings of Ukraine. The research methodology was formed by a set of general scientific and special methods of cognition. The use of these methods was mostly complex, due to the specifics of the topic of the scientific article. In particular, the systematic method is used in the study of the categorical apparatus, namely in defining the concepts of “electronic court” and “electronic administrative proceedings”. The formal-legal method is also used to clarify the content of legal concepts. The author uses the dialectical method of cognition during the research and systematization of the stages of development of electronic administrative proceedings in Ukraine. The periodization proposed by the author is based on a significant amount of normative material that regulates the functioning of e-justice in Ukraine. Thanks to the methods of synthesis and generalization, the main possibilities of e-justice, which can be used by a participant in the administrative process, have been identified. The results of the study are to define and clarify the concept of “electronic court” based on the analysis of scientific views and current legislation of Ukraine. The concept of “electronic court” in the broad and narrow sense. The preconditions for the emergence of electronic administrative proceedings in Ukraine have been studied and it has been established that the informatization of the judicial system has led to the formation of a new way of administering justice – electronic, ie on the basis of information and telecommunications technologies. The main stages of development of electronic administrative proceedings in Ukraine are highlighted and characterized, and the successful implementation of the e-court project in Ukraine is emphasized. On the basis of the analysis of the current legislation of Ukraine the peculiarities of the functioning of the “electronic court” are determined and the new possibilities of the “electronic court” are singled out, which are given to the participants of the administrative process during their administrative cases. It is concluded that at the present stage of development of the judicial system of Ukraine, electronic administrative proceedings are only at the stage of their formation and require a lot of effort for their full and effective functioning. Emphasis is placed on the success that our judicial system has achieved in implementing this project. Therefore, further research and implementation of this project is one of the main ways to improve the efficiency of justice in Ukraine.
The Theme of Faith and Faithlessness in Works of A.S. Norov of the 1820s
Authors: Kotanchan R.V.
Published: August 2022

The article is devoted to actual questions of religious literary criticism. The object of research is the literary process of the nineteenth century. The subject is A.S. Norov’s work. He is a Russian poet of the second circle of the literary process of the nineteenth century. The article contains descriptions of religious problematics and themes of the poem «The Temple», which is the translated version of the poem of A. de Lamartin. This research provides characteristics to religious and philosophical questions of the poem «The Temple». The target of the research is the characteristic of A.S. Norov’s work. Particular attention is paid to the theme of faith and disbelief. The scientific novelty consists of providing new facts about religious problematics of Russian classical literature.
Compactness in General Category Theory
Authors: Garg Kamaldeep
Published: August 2022

Let S ? ? |Q?|. It has long been known that there exists an universally Perelman, discretely regular, characteristic and essentially Pythagoras sub-canonically complete, Shannon, quasi-reversible topos [22]. We show that N? is trivially infinite. Unfortunately, we cannot assume that S (n(Q)) < B(X ). This leaves open the question of existence.
Viability of Risk-return Trade-off within a South African Context
Authors: Robbetze Natasha , Swanepoel Matthys Johannes
Published: August 2022

Research aims: This study aimed to determine whether systematic risk and return are related to each other. It answered the research question: Is it realistic for investors to expect high returns when their investments are associated with more riskiness?Design/Methodology/Approach: Quantitative analysis was applied through a correlational research design. Secondary data were collected from the Integrated Real-time Equity System (IRESS). The Statistical Package for Social Sciences (SPSS) was utilised to measure a Pearson correlation coefficient and execute multiple regression analysis. This was done to test for the relationship between financial measurements of systematic risk and return, of sampled entities.Research findings: This research found that measures of systematic risk and return are not necessarily related when empirically analysed for sampled entities.Theoretical contribution/Originality: This paper indicated that the principle of the modern portfolio theory (MPT) should not be accepted as general truth. It should not be assumed that risk and return are linearly related in all financial markets under all economic circumstances. This premise is contrary to general financial management practice, where the MPT is universally accepted and even forms the basis of other financial theories.Research limitation: The use of the IRESS database posed a limitation in terms of sampling, as the database was frequently unable to present a complete set of data needed for statistical testing. Consequently, only 33 companies were sampled, as IRESS only made a complete set of required data available for these entities.
Tanggung Jawab Negara dalam Pemenuhan Jaminan Sosial Persepektif Welfare State
Authors: Pamungkas Tareq Jati , Hariri Achmad
Published: August 2022

The welfare state is intended to provide social services for all its citizens, as well as possible. In the concept of a welfare state, a country provides assistance or social security with the aim of achieving prosperity and welfare for its population. This study aims to determine the implementation of state responsibilities in welfare. The problem studied in this research is how the form of state responsibility in the perspective of the welfare state and how the form of social security responsibility according to Law no. 24 of 2011 concerning BPJS in the perspective of the welfare state. This study uses a type of normative research method based on written regulations and literature study. The results of this study indicate that the responsibility given by the welfare state is in the form of social services. In an effort to be responsible for realizing a welfare state, it is to make social policies by providing basic protection and services for compulsory education, basic living needs, health care, and social protection to vulnerable groups.
СТВОРЕННЯ НАВЧАЛЬНИХ ВІДЕО ТА ЇХ ВИКОРИСТАННЯ
Authors: Шаблій Любов Матвіївна
Published: August 2022

У статті розглядаються особливості використання програмного забезпечення для редагування та монтажу відео у процесі створення мультимедійних засобів навчання.
Casos didácticos: notas sobre una estrategia de investigación y formación para docentes
Authors: Extremera Marta María Olmo , Cavalcante Maria Mikaele Silva
Published: August 2022

Este artículo versa sobre una discusión de casos de enseñanza caracterizados por ser una producción escrita orientada hacía la problematicación de un tema específico. Del mismo modo, es considerado como un procedimento de investigación y una estratégia de formación para los docentes. La literatura sobre casos en el ámbito de la educación es escasa, razón que justifica las pocas investigaciones y discusiones sobre el asunto. Por esta razón y a partir de este trabajo, se tiene en cuenta una revisión conceptual (MIZUKAMI, 2006; ROESCH, 2007; MUSSI, 2007; LACERDA, 2011) y un caso de enseñanza específico y concreto. También se presenta un análisis y orientaciones de casos didácticos como una metodológica y una estrategia de formación docente, que buscan ampliar y divulgar esta herramienta entre los investigadores de la educación.
Austeridade fiscal no financiamento da educação em Curitiba (2017 – 2019): uma perspectiva crítico dialética
Authors: Da Silva Marcus Quintanilha
Published: August 2022

O objetivo desse trabalho foi de discutir as hipóteses explicativas para a adoção da austeridade fiscal no financiamento da educação no município de Curitiba-PR entre 2017 e 2019. A abordagem crítico dialética (BEHRING; BOSCHETTI, 2011), metodologia de análise de políticas sociais que, para as limitações propostas por esse estudo, visou compreender os pontos de vista histórico, econômico e político do objeto de pesquisa, foi norteada por uma discussão sobre disputa pelo fundo público e austeridade fiscal. Como o ponto de partida foi a ausência de crise na arrecadação municipal, argumento comumente utilizado pelos governantes que adotam os ajustes fiscais como prerrogativa de retomada de crescimento, a ideologia partidária, as políticas nacionais como possíveis indutoras das ações locais e as disputas em torno do fundo público no âmbito municipal constituíram as hipóteses explicativas ao objeto analisado.
Resenha Notas sobre “Diálogos sobre Políticas Educacionais: resistência na Educação do Campo”
Authors: Gonçalves Leonardo Dorneles
Published: August 2022

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STAT3 Expression and Correlation Between Ki-67 and PHH3 in Meningiomas: Is it Possible to Predict Recurrence?
Authors: KANTARCIOĞLU COŞKUN Sinem , KILIÇ Güven
Published: August 2022

Aim: The aim of this study was to investigate the correlation between PHH3 and ki-67 labeling index, and the association of STAT3 expression with mitotic index, grade by World Health Organization 2016 classification, and clinicopathological features of meningioma cases.
Material and Methods: A total of 25 meningioma cases from the archives of the Department of Pathology, Düzce University School of Medicine, diagnosed between 2012 and 2021 were included in the study. The mitotic count from the ten fields with the highest number of mitotic figures was determined. Immunohistochemistry was performed on the formalin-fixed, paraffin-embedded tissue blocks to determine STAT3, ki-67, and PHH3 expression. STAT3 was scored between 0 and 3 points according to staining intensity. Staining percentages for STAT3 were determined using a manual count of stained cells and the total number of tumor cells. The ki-67 labeling index was determined as a percentage by a manual count. For PHH3, the total number of immunostained mitotic figures per 10 high-power fields were evaluated in each case.
Results: A statistically significant difference was found in terms of the percentage of STAT3 staining between the tumor grades (p=0.047). STAT3 expression was significantly higher in cases with high tumor grades. A moderate positive correlation was found between ki-67 and PHH3 when calculated as a percentage in the area with the highest mitotic index by manual counting (r=0.621, p=0.001).
Conclusion: A combination of ki-67, PHH3, and STAT3 will be useful in the grading of meningiomas and predict the recurrence.
Dyskurs prawniczy, interpretacja i argumentacja. Kilka uwag
Authors: Brzeziński Bogumił
Published: August 2022

Problematyka wykładni prawa budziła i budzi duże zainteresowanie zarówno praktyki, jak i nauki prawa. Tradycyjne topiki prawnicze są nadal w powszechnym użyciu, ale w teorii prawa poszukuje się dla nich podbudowy w zasadach komunikacji powszechnej, modyfikując je pod potrzeby interpretacji tekstów normatywnych. Współcześnie najwięcej uwagi poświęca się w tym zakresie tzw. maksymom i implikaturom Paula Grice’a.
Ograniczenie zakresu stosowania w Polsce autoryzowanego podejścia OECD dotyczącego przypisywania zysku do zagranicznego zakładu
Authors: Laskowska Monika
Published: August 2022

W artykule omówiono zagadnienia dotyczące stosowania przepisów w zakresie przypisywania zysku do zagranicznego zakładu – wynikających zarówno z umów podatkowych, jak i przepisów krajowych po ich zmianie od 2019 r. Wskazano na błędnie przyjęte w polskich ustawach podatkowych dotyczących opodatkowania dochodu założenie o tożsamości relacji pomiędzy zagranicznym zakładem i jednostką macierzystą z relacjami pomiędzy podmiotami powiązanymi. W konsekwencji tego założenia od 2019 r. stosowanie przepisów krajowych dotyczących zagranicznego zakładu prowadzi do zjawiska podwójnego opodatkowania lub podwójnego nieopodatkowania dochodu.
Do institutions mitigate the uncertainty effect on sovereign credit ratings?
Authors: Ramírez Rondán Nelson R. , Rojas Rojas Renato M. , Villavicencio Julio A.
Published: August 2022

En un mundo económico y financiero cada vez más integrado, las calificaciones crediticias soberanas se han convertido en uno de los factores más importantes para los países que buscan acceder a fondos en el mercado internacional de bonos. En primer lugar, analizamos conjuntamente las instituciones y la incertidumbre como determinantes de las calificaciones crediticias soberanas y, en segundo lugar, comprobamos si las instituciones fuertes suavizan el impacto de la incertidumbre. Utilizando una muestra de 74 países de 2003 a 2020 para las principales agencias Moody’s, Standard&Poor’s, y Fitch, y empleando un enfoque de estimadores ordenados, encontramos que las instituciones tienen un efecto positivo, mientras que la incertidumbre tiene un efecto negativo, y la interacción entre ellos es sistemáticamente negativa. Estos resultados indican que unas instituciones fuertes reducen el efecto negativo de la incertidumbre en las calificaciones crediticias de los países.
​​Impact of Nagaland State Rural Livelihood Mission (NSRLM) on Livelihood Status of Women in Nagaland
Authors: Konyak Oungngoi C.S. , Das Sanjoy , Patra N.K.
Published: August 2022

Background: The Nagaland State Rural Livelihood Mission is the implementing agency for the NRLM in the state and embodies the principles and vision of NRLM while keeping in mind the unique features of the state. The Mission aims at bringing about sustained improvement in the household incomes, livelihood, well-being and empowerment status of the rural poor through sustained livelihood enhancements and improved access of financial and non-financial services. The present study was about an impact of NSRLM on socio-economic and livelihood status of rural women in Mon District of Nagaland. Methods: A total of 100 respondents (80 beneficiary and 20 non beneficiary respondents) were surveyed. Ex post facto research design was used for the study. Both primary and secondary data were used. Collected data were scrutinized and statistically analyzed using statistical tools like t-test, Pearson’s correlation analysis and index analysis to draw valid conclusions. To measure the impact, six types of assets viz., human assets, physical assets, natural assets, social assets, financial assets and food security were considered. Result: Annual income earned from different sources, expenditure and saving of NSRLM beneficiary respondents found increase in comparison to non beneficiary respondents. The average assets value, average annual household income and average annual household expenditure per household of the beneficiary respondents were found comparatively greater than that of non-beneficiary respondents. Beneficiary respondents remained significantly better off than that of non-beneficiary respondents in all six types of asset creation. Some of the independent variables viz., age, income and expenditure were found positively and significantly associated with creation of human assets, financial asset and food security among the beneficiary respondents.
Recycling of Leaf Litters: Biowaste Management for Resource Conservation
Authors: Isaac Sheeba Rebecca , George Amala Mary
Published: August 2022

The search for viable agricultural production systems in the era of unpredictable climate events has elevated the prospects of agroforestry practices for resilience and sustainability. The litter biomass in these ecosystems govern the biogeochemical nutrient cycling prevalent, but can also serve as organic inputs in crop production under situations where these are considered as menace and cumbersome to dispose. When left to decay under natural conditions litter takes a considerably long time for decomposition and release of nutrients entrapped in them. With the increasing need to conserve natural resources and energy, recycling of organic wastes assumes major significance. Leaf litters are untapped sources of nutrients and are generated in substantial quantities in most of the agroforestrty systems. Among the different alternatives available for recycling biomass residues, composting is considered most efficient and viable option, but recent innovations such as biochar production and thermochemical digestion have also been attempted. Organic farming strategies call for in situ production of nutrient inputs for economic viability of the practice and hence information on alternative technologies to enrich the repository of organic manures in the form of litter compost will be of immense importance. These composts could be recycled to soil for enriching soil organic carbon, plant nutrients and to sustain soil health in the long run. Proper utilization of the biowastes in the tree based systems will also ensure reduction in environmental pollution and forest fire incidents that otherwise threaten life. The review unveils the possible technologies for recycling the litter and use as a nutrient source but emphasizes the need for a suitable environment favouring the rapid decomposition.
Varietal Roles on Morpho-physiological and Yield Attributes of Lentil (Lens culinaris Medik)
Authors: Chowhan Sushan , Islam Majharul
Published: August 2022

Background: Lentil is the top cultivated pulse crop in Bangladesh. Even if there are a number of modern high yielding varieties (HYV) with all natural favorable conditions and resources for cultivation but due to lack available stress and climate (biotic and abiotic) resilient variety; potential yield of this crop is rarely met. Against huge sum of demand the supply is deficit in the country which is met by importing. Reflecting this situation, the present investigation attained to test the morpho-physiological and yield related attributes of seven HYV of lentil and depict the most suitable variety in terms of growth, yield and maturity. Methods: Binamasur-5, Binamasur-8, Binamasur-9, Binamasur-10, BARI Masur-5, BARI Masur-6 and BARI Masur-8 was laid in a randomized complete block design during the rabi (winter) season of 2019 at BINA sub-station farm, Magura. Result: Findings divulged that, Binamasur-10 had the most seed yield (2.08 t/ha), harvest index (HI) (25.15%) and with medium duration of maturity (108.94 days). BARI Masur-5 produced maximum stover yield (7.86 t/ha) with delayed maturity (114 days) and least seed yield (1.75 t/ha) among the evaluated varieties. Correlation study exposed that, seed yield had a positive and significant relationship with plant height (0.78*), number of primary and secondary branches (0.76* and 0.75*), total dry mass (0.87**) and HI (0.85**). However, Binamasur-10 might be more suitable than the other varieties in the field due to it’s notable performance.
Adolescent Experience With Dating Violence in Relation to Virginity Status: Findings From a Jamaican Sample
Authors: Mason Gillian E.
Published: August 2022

The association between adolescents’ involvement in sexual intercourse and their experiences with adolescent dating violence (ADV) is an understudied topic. This study examined this relationship for 178 Jamaican adolescents in Grades 9–11. The expectation that adolescents who reported having had sexual intercourse would report greater victimization and greater perpetration than adolescents who had not had intercourse was consistent only for sexual abuse. Analyses also showed that sexually experienced males perpetrated and experienced more psychological abuse compared to males who were not so experienced. These results suggest different experiences based on adolescents’ sex and so support others’ calls for ADV research to do more examinations by sex. Also, it endorses the importance of doing research on both victims and perpetrators of intimate abuse. Implications of these findings for sexual and relationship education of adolescents are discussed.
Brexit y migración: revisión de literatura
Authors: Guerrero Molina María Isabel , Salazar Acevedo Juan Felipe , Taborda Giraldo Julián
Published: August 2022

La incertidumbre generada con la separación del Reino Unido de la Unión Europea constituye un evento histórico y sin precedentes, conllevando a un ambiente de discordia dentro y fuera del bloque económico, en especial para los migrantes, debido a las consecuencias que ha desatado el Brexit. La revisión de literatura se basó en un mapeo científico sobre la influencia de los migrantes europeos, abordados desde el Brexit y las consecuencias, tendencias y políticas migratorias. Se utilizó la base de datos Scopus en el periodo 2015-2021, mediante herramientas bibliométricas y RStudio se revisó el tema basado en la metáfora del árbol; se concluye con 3 temáticas de estudio: perspectiva social y cultural de los migrantes; impacto económico y laboral asociado al Brexit y; política, debates y votación sobre consecuencias del Brexit, que permiten determinar una tendencia sobre la evolución y consecuencias de la separación del Reino Unido de la Unión Europea.
The Level of Knowledge and Nurse Attitude in the Application of Five Moments Hand Hygiene in a Private Hospital in the Western part of Indonesia
Authors: Larosa Cornelia Ayu Kristina , Panjaitan Criesty Fransiska Junita , Ingrit Belet Lydia , Panjaitan Tirolyn
Published: August 2022

Hand hygiene is very important for health workers to reduce infection rates in health services area. Five Moments Hand Hygiene is one of strategy for health workers to keep safe from infections. Knowledge and attitudes by nurses about hand hygiene can influence nurse behavior and have an impact to improving patient health for reducing the spread of infection. To describe the level of knowledge and attitudes of nurses in applying the Five Moments Hand Hygiene in a Private Hospital in Wester part of Indonesia. This study used descriptive quantitative with the population are all nurses and the sample in this study were 46 nurses with total sampling technique. The instrument in the study used a questionnaire with level of knowledge and nurse attitude as variables. The data analysis technique is univariate. This study used ethical principles and has received ethical approval from The Research Committee Ethic Faculty of Nursing. The study shows  that nurses had a good (80,43%) knowledge of Five Moments Hand Hygiene but had a sufficient (54,35%) attitude in applying the Five Moments Hand Hygiene. Conclusion of this study is that most nurses have good knowledge but have sufficient attitude in applying Five Moments Hand Hygiene. For further researchers, it is recommended to find the relationship between knowledge and attitudes of nurses in applying the Five Moments Hand Hygiene.
Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study
Authors: Njom Nlend Anne Esther , Gwodog Josepha , Sandie Arsene Brunelle
Published: August 2022

Objective To Identify risk factors of perinatal complications amongst macrosomic babies in a reference hospital structure. Method We conducted a case-control institutional based study. Cases and controls of singleton livebirths were extracted from the maternity registry from January 2017 to December 2019 The case population consisted of mother and child macrosomic couples with perinatal complications. The control group consisted of couples without perinatal complications. Matching was done on age and sex. The main primary end point was the risk factors for complications. Data were analyzed using R, software version3.0 in adjusted and unadjusted analysis with p<0.05 threshold considered statistically significant. Results Out of 362 couples, we had 186 cases and 176 controls. Maternal age ≥30 years (p=0.024); non-screening for gestational diabetes (p=0.027); history of caesarean section (p=0.041); weight gain ≥16 kg (p<0.001); maternal HIV (p=0.047); birth weight ≥4500g (p=0.015) and birth height ≥ 52.7 ±1.7cm (p=0.026) were risk factors. Conclusion The delivery of a macrosomic baby remains problematic in this setting. The improvement of the maternal-fetal prognosis requires quality prenatal surveillance and management by a multidisciplinary perinatal team involving obstetricians, endocrinologist, and neonatal pediatricians.
Computer Programming for Analysis and Design of Edge Supported Rectangular Two-Way Solid Slab by Es En 1992-1-1:2015
Authors: Chawaka Chala
Published: August 2022

This study’s main target was to analyze and design rectangular edges supported in two ways 1 solid slabs by using ES EN 1992-1-1:2015. Slab design is often carried out either manually or with 2 the use of design and analytic software. The researcher sees that some software cannot accept some 3 countries’ standard codes. For example, currently in Ethiopia analysis and design of two-way solid 4 the slab is done using a readily available Excel sheet template. But working with this might have many 5 problems, firstly the structure that is already analyzed by SAP or SAFE or any other international 6 a software application that uses international codes but which cannot design structure using ES EN 7 1992; for instant euro codes and designed by excel sheet can create failure and uneconomical analysis 8 and design result. In this paper, the slab is designed and analyzed based on the chosen concrete grade, 9 chosen reinforcement bar diameter, chosen steel grade for design and analysis of slabs calculations 10 like load, moment, shear, and deflection checking using the moment coefficient method for analysis 11 and design and Microsoft Visual Basic 2010 for coding. All input values are given by the International 12 Standard units are also used to represent output values. Using manual calculations delays time 13 and mostly the result is not correct. But using this Computer program can increase computation 14 accuracy and save time. The procedure the researcher followed is, first the manual calculation has 15 been done and then SADSE2021 has been done. The result is that both are 99.9 percent identical, and 16 the disadvantage of this method is that it cannot be used to determine the detailed drawing.
The Present and Future of Clinical Management in Metastatic Breast Cancer
Authors: Lin Pauline , Laliotis George
Published: August 2022

Regardless of the advances in our ability to detect early and treat breast cancer, it is still one of the common types of malignancy worldwide, with the majority of patients decease upon metastatic disease. Nevertheless, due to these advances, we have extensively characterized the drivers and molecular profiling of breast cancer and further dividing it into subtypes. These subgroups are based on immunohistological markers (Estrogen Receptor-ER, Progesterone Receptor-PR and Human Epidermal Growth Factor Receptor 2-HER-2) and transcriptomic signatures, with distinct therapeutic approaches and regiments. These therapeutic approaches include targeted therapy (HER-2+), endocrine therapy (HR+) or chemotherapy (TNBC) with optional combination radiotherapy, depending on clinical stage. Technological and scientific advances in the identification of molecular pathways that contribute to therapy-resistance and establishment of metastatic disease, have provided the rationale for revolutionary targeted approaches against Cyclin-Dependent Kinases 4/6 (CDK4/6), PI3 Kinase (PI3K), Poly ADP Ribose Polymerase (PARP) and Programmed Death-Ligand 1 (PD-L1), among others. In this review, we focus on the comprehensive overview of epidemiology and current standard of care treatment of metastatic breast cancer, along with ongoing clinical trials. Towards this goal, we utilized available literature from PubMed and ongoing clinical trial information from clinicaltrials.gov to reflect the up to date and future treatment options for metastatic breast cancer.
Profil keterampilan metakognitif siswa pada pembelajaran biologi secara online di masa pandemi covid-19
Authors: Setyawati Octaviana Ika , Fitakurahmah Nur
Published: August 2022

Pendidikan di abad 21 menuntut peserta didik memiliki keterampilan yang mampu menunjang aktivitasnya di dunia kerja. Keterampilan yang dibutuhkan antara lain keterampilan pemecahan masalah, komunikasi, dan metakognitif. Aktivitas metakognitif berhubungan dengan pengorganisasian informasi, pengalaman, tujuan, dan strategi yang mendukung pemecahan masalah. Penelitian ini bertujuan untuk mengungkap profil keterampilan metakognitif siswa SMA dalam pembelajaran biologi online selama masa pandemi Covid-19. Keterampilan metakognitif adalah kemampuan seseorang untuk mengontrol proses berpikir. Penelitian ini merupakan jenis penelitian kualitatif. Teknik pengumpulan data menggunakan metode survei. Survei dilakukan dengan menyebarkan google form yang berisi kuesioner MAI (Metacognitive Awareness Inventory) kemudian dianalisis dengan menggunakan persentase deskriptif. Populasi penelitian ini adalah seluruh siswa SMA. Sampel penelitian ini adalah sampel acak seluruh siswa. Subyek dipilih dengan menggunakan teknik random sampling. Hasil survei digunakan untuk mengetahui data tentang kemampuan metakognitif siswa. Hasil keterampilan metakognitif siswa dari setiap aspek adalah kondisional 26,7%, perencanaan 24,3%, pemantauan 22,8%, deklaratif 20,5%, prosedural 20,3%, dan evaluasi 17,8%.

 

Metacognitive skills profile of students on online biological learning during the covid-19 pandemic. Education in the 21st century requires students to have skills that are able to support their activities in the world of work. The skills needed include problem solving, communication, and metacognitive skills. Metacognitive activities relate to organizing information, experiences, goals, and strategies that support problem solving. This study aims to reveal the profile of high school students' metacognitive skills in online biology learning during the Covid-19 pandemic. Metacognitive skills are a person's ability to control the thinking process. This research is a type of qualitative research. The technique of collecting data using survey methods. The survey was conducted by distributing a google form containing the MAI (Metacognitive Awareness Inventory) questionnaire then analyzed by using a descriptive percentage. The study population was all high school students. The research sample was a random sample of all students. Subjects were selected using random sampling technique. The survey results were used to find out data about students' metacognitive skills. The results of students' metacognitive skills from every aspect were 26.7% conditional, 24.3% planning, 22.8% monitoring, 20.5% declarative, 20.3% procedural, and 17.8% evaluation.
MALIGNANT NEOPLASMS OF FEMALE REPRODUCTIVE ORGANS IN DYNAMICS in 2011-2020, ON THE EXAMPLE OF NOVOKUZNETSK
Authors:   Novokuznetsk State Institute of Advanced Medical Training, Branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Zhilina N.M. , Shramko S.V. ,   Novokuznetsk State Institute of Advanced Medical Training, Branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation
Published: August 2022

Significance. Malignant neoplasms are among the leading socially significant diseases. In recent years, the mortality rate from malignant neoplasms among females aged 16-54 in Russia has taken first place, slightly ahead of the traditional leader - mortality from diseases of the circulatory system. Therefore, early detection of oncopathology, including reproductive organs, means preservation of life, health and performance capability, and ultimately, the quality of female life, including young and middle-aged women. Purpose: to identify risk zones of oncopathology of female reproductive organs to ensure timely and adequate control actions and women's health improvement. Material and methods. The study was based on statistical reports of the Regional clinical oncology dispensary (Novokuznetsk branch) for 2011-2020. The reporting information has been translated into a database format (DB) with a 1-year observation unit. The database was created in the licensed statistical package IBM SPSS Statistics-19. The following methods of statistical analysis were used: calculation of median values of indicators, upper and lower quartiles; the Kendall’s Tau correlation method (Ʈ), the Mann-Whitney criterion (U). Results. The risk zones of oncopathology of the female population of Novokuznetsk as a whole and by age groups were identified. In terms of morbidity and mortality per 100 000 population, malignant neoplasms of the breast have the highest morbidity indicator, while ovarian cancer has the highest mortality rate during the year. At the same time, the highest detectability of stages III and IV of oncological diseases is in ovarian cancer. The risk zones of oncopathology by age are as follows: cervical cancer in females aged 40-44, breast cancer in females aged 60-64 and 65-69, and endometrial cancer and ovarian cancer in females aged 65-69. In these ages, the highest levels of the studied morbidity in the dynamics in 2011-2020 were revealed. Cervical cancer and breast cancer have a negative trend in crude incidence: a statistically significant growth of both absolute and relative (per 100 thousand population) indicators was revealed. As to ovarian cancer localization, there is a tendency towards a decreasing absolute indicator. Conclusions. The main study results can be used to conduct preventive examinations and medical examinations of women with a focus on identifying risk zones of the reproductive organ cancer by age group and localization. Thus, the results obtained contribute to adopting adequate and timely medical interventions and improvement of women's health.
LINGUISTIC DETERMINANTS OF HEALTH OF TRANSGENDER PEOPLE
Authors:   Eurasian Coalition on Health, Rights, Gender and Sexual Diversity, Tallinn, Estonia, Kirey-Sitnikova Y.
Published: August 2022

Significance. During the last few decades epidemiology has come a long way from taking into account only biological mechanisms influencing human health towards inclusion of socio-economic, legal and political factors. However, linguistic determinants of health have received little scholarly attention. The present article highlights some challenges in the design of epidemiological studies that would credibly demonstrate the impact of linguistic factors on health outcomes on the example of transgender issues. The purpose of the study is to analyze the impact of linguistic factors on health outcomes of transgender individuals. Identify methodological challenges in the design of epidemiological studies that would credibly prove causation between linguistic factors and health outcomes. Material and methods. Content analysis of literature on the impact of hate speech, misgendering and deadnaming on health outcomes of transgender individuals. Results. Qualitative and quantitative data shows a negative impact of such linguistic practices as hate speech, misgendering and deadnaming on mental and physical health of transgender individuals. Nevertheless, the lack of clear definitions of those concepts, reliance on self-reported scales and existence of confounders (physical appearance and legal gender/name) makes it impossible to generate evidence of high credibility.
Progress Toward Pilot-Scale Simulation of In-Situ Combustion Incorporating Geomechanics
Authors: Li Y. , Manrique E. J. , Kovscek A. R.
Published: August 2022

In-situ combustion (ISC) is a promising thermal enhanced oil recovery method with benefits for deep reservoirs, potentially lesser energy requirements as compared to steam injection, and low opportunity cost. Although successful ISC projects have been developed all over the world, challenges still exist including difficulties in monitoring combustion-front progress in the field, describing multiscale physical processes, characterizing crude oil kinetics fully, and simulating ISC at field scale. This work predicts combustion front propagation and the effect of thermally induced stress at the scale of an ISC pilot project. Reservoir deformation was characterized by a geomechanical model to investigate the correlation of combustion front progress with reservoir and surface deformation. We upscaled the reaction kinetics directly from combustion tube experiments and calibrated the laboratory-scale model compared with experimental measurements. We then upscaled numerical simulation to a 3D geometry incorporating a geomechanical model. The change in scale is significant as the combustion tube is 6.56 ft (2 m) in length, whereas the dimensions of the 3D model are 1,440 ft by 1,440 ft (439 m) by 1,400 ft (427 m). The elastic properties were defined by Young’s modulus and Poisson’s ratio, whereas the plastic properties were defined by a Mohr-Coulomb model. A sensitivity study examined the reliability of the model, showing the reaction progress and geomechanical responses were not significantly impacted by gridblock dimensions and reservoir heterogeneity. Finally, a field-scale model was developed covering an area of 5,960 ft (1817 m) by 4,200 ft (1280 m). We observed successful ISC simulation including ignition as air injection started. The temperature increased immediately to more than 800°C (1,400°F) based on the chemical kinetics implemented. The temperature history indicated that the combustion front propagated from the injection well into the reservoir with an average velocity of 0.16 ft/D (0.049 m/d). A surface deformation map correlated with the progress of ISC in the subsurface. Land surface uplift because of ISC ranges from 0.1 ft (0.03 m) to several feet, depending on the rock properties and subsurface events. This proof-of-concept model indicated strong potential to detect the surface movement using interferometric synthetic aperture radar (InSAR) and/or tiltmeters to monitor dynamically combustion front positions in subsurface.
New Insight into the Spatial Autoregressive Model of Industrial Wastewater Discharge in the Yellow River Basin
Authors: Xia Libo , Wang Zhiliang , Du Shuang , Tian Decun , Zhou Yun
Published: August 2022

This article has carried out a statistical analysis of the industrial wastewater discharge (IWD) and gross regional product (GRP) of 79 cities in the Yellow River Basin from 2003 to 2019. By calculating the Moran index of IWD and GRP, the study has found that a certain spatial autoregressive in space. There is an environmental Kuznets curve (EKC) between the environmental pollution and economic development of cities in the Yellow River Basin, and a spatial autoregressive is modelled by a set of random effects that are assigned a conditional autoregressive prior distribution. In the Bayesian environment, Markov chain Monte Carlo (MCMC) is used for inferencing, and the spatial weight matrix is ​​selected to be U-shaped matrix, and the error of the model is minimized. The parameter posterior distribution results of the model showed that the GRP did not show a significant decline. The modified EKC showed that the discharge of industrial wastewater in the entire Yellow River Basin will be reduced. Generally, cities with high pollutant emissions should learn from other cities to reduce emissions, and cities with low GRP need to increase local economic development.