bluuebunny/crossref_metadata_2025 huggingface dataset:
Sorption Preconcentration of Heavy Metals on Graphene Oxide for Analysis of Waters by Electrothermal Vaporization ICP-OES
Authors: Medvedev Nikolay S. , Frolova Alexandra O. , Kurbatova Valeriya D. , Guselnikova Tatiana Ya. , Makotchenko Viktor G. , Saprykin Anatolij I.
Published: January 2025

Background:

Heavy metals (HMs) such as Cr, Hg, Pb, etc., are major threats to human
health due to their toxic and carcinogenic properties. So, the determination of HMs concentrations in
waters is an actual and important task.

Methods:

In this paper, the method includes a preliminary concentration of HMs and other analytes
(Ag, Au, Ba, Be, Bi, Cr, Hg, In, Pb, Sn, and Zn) from water solutions on the graphene oxide and
subsequent analysis of slurries of sorbent by electrothermal vaporization inductively coupled plasma
optical emission spectrometry (ETV-ICP-OES) is developed for the first time.

Results:

The high efficiency of analytes sorption on graphene oxide made it possible to significantly
increase the sensitivity of the analysis. The limits of detection of Ag, Au, Ba, Be, Bi, Cr, Hg, In, Pb,
Sn, and Zn from 0.7 to 300 ng L-1 are achieved for ETV-ICP-OES analysis. The use of electrothermal
vaporization for sample introduction allows the analysis of sorbent suspensions and avoids the
desorption stage, reduces sample dilution, increases the preconcentration factor, and improves limits
of detection (LODs) of analytes by 2-33 times compared to routine inductively coupled plasma optical
emission spectrometry analysis (ICP-OES) with sorption preconcentration.

Conclusion:

For Ba, Be, Bi, Cr, In, Pb, Sn, and Zn ETV-ICP-OES provides LODs from 2 to 33
times lower compared to conventional ICP-OES analysis with sorption preconcentration due to higher
preconcentration factor and transport efficiency of introducing of the analytes concentrates into
the ICP. The developed method was applied to the analysis of real tap and mineral water samples.
The results of analysis by ETV-ICP-OES with preconcentration of trace elements and ICP-OES were
in good agreement. As a result of lower LODs of analytes, ETV-ICP-OES analysis provides the determination
of concentrations of Ba, Bi, Sn, and Pb in tap and mineral water samples.
Remimazolam in Modern Anaesthesia Practice: From Pharmacokinetics to Clinical Outcomes
Authors: Kateel Ramya , Bhat Ravitej
Published: January 2025

Remimazolam, a novel ultra-short-acting benzodiazepine, has emerged as a promising
agent in the field of anaesthesia and sedation. This comprehensive review examines the pharmacological
properties, clinical applications, and safety profile of remimazolam. Its unique pharmacokinetic
profile, characterised by rapid onset and offset of action, organ-independent metabolism, and
availability of a specific reversal agent, offers potential advantages over traditional sedatives. Clinical
studies have demonstrated its efficacy in procedural sedation, particularly in gastrointestinal
endoscopy and bronchoscopy, as well as in the induction and maintenance of general anaesthesia.
Emerging evidence also suggests its potential utility in intensive care sedation. Remimazolam has
shown a favourable safety profile, with studies indicating comparable or improved hemodynamic
stability and potentially reduced respiratory depression compared to propofol. The availability of
flumazenil as a reversal agent enhances its safety profile. However, as with any relatively new
medication, ongoing research is needed to fully characterise its long-term safety and optimal use
in various clinical scenarios. This review synthesises current knowledge on remimazolam, providing
insights into its potential to optimise sedation and anaesthesia practices across diverse patient
populations and clinical settings, while highlighting areas for future research.
The Estimation Value of 99mTc-MAA in Comparison with 90Y-PET/MR-based Dosimetry in Selective Internal Radiation Therapy (SIRT) for Liver Malignancies
Authors: Yeyin Nami , Abuqbeitah Mohammad , Namazova Aysel , Demir Mustafa
Published: January 2025

Background:

Neurodegenerative diseases are a group of disorders characterized by progressive
neuronal degeneration and death, of which Alzheimer's disease and Parkinson's disease
are the most common. These diseases are closely associated with increased expression of monoamine
oxidase B (MAO-B), an important enzyme that regulates neurotransmitter concentration, and
its overactivity leads to oxidative stress and neurotoxicity, accelerating the progression of neurodegenerative
diseases. Therefore, the development of effective MAO-B inhibitors is important for
the treatment of neurodegenerative diseases.

Objective:

This study aims to improve the prediction of the efficacy of novel 6-hydroxybenzothiazole-
2-carboxamide compounds in inhibiting MAO-B by improving the quantitative constitutive
effect relationship (QSAR) modeling and to provide a theoretical basis for the discovery of
novel neuroprotective drugs.

Methods:

The study first optimized the structures of 36 compounds using the heuristic method
(HM) in CODESSA software to construct linear QSAR models. Subsequently, key descriptors were
screened by using the gene expression programming (GEP) technique to generate nonlinear QSAR
models and validate them.

Results:

The R², F-value, and R²cv of the linear model were 0.5724, 10.3752, and 0.4557, respectively,
whereas the nonlinear model constructed by the GEP algorithm showed higher prediction
accuracies by achieving R² values of 0.89 and 0.82, and mean squared errors (MSE) of 0.0799 and
0.1215 for the training and test sets, respectively. In addition, molecular docking experiments confirmed
that the novel compound 31 was tightly bound to the MAO-B active site with significant
inhibitory activity.

Conclusion:

In this study, we successfully improved the prediction ability of the efficacy of novel
6-hydroxybenzothiazole-2-carboxamide compounds to inhibit MAO-B by improving the QSAR
model. This not only provides new drug candidates for the treatment of neurodegenerative diseases,
but also provides important theoretical guidance for subsequent drug design and development,
which can help accelerate the process of new drug discovery and reduce the disease burden of patients.
Uncovering the Healing Power of Stem Cells: Harnessing Regenerative Therapies for Alzheimer's Disease
Authors: Mehrabadi Shima
Published: January 2025

Alzheimer's disease is a progressive neurodegenerative disorder with no known treatment.
Recent advances in regenerative medicine, including stem cell therapies, hold promise for
treating Alzheimer's disease and slowing its progression. This review explores the various types of
stem cells, such as neural and mesenchymal stem cells, and how they can be harnessed for
Alzheimer's treatment. It also discusses the potential mechanisms of action, including neurogenesis,
anti-inflammatory and anti-apoptotic effects, and the secretion of various biologically active
molecules by stem cells.
Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based
Second-Generation Artificial Intelligence System
Authors: Rinott Ehud , Sigawi Tal , Hurvitz Noa , Elchatib Narmin , Rinsky-Halivni Lilah , Ilan Yaron
Published: January 2025

Objective:

Regular physical activity (PA) promotes mental and physical health. Nevertheless,
inactivity is a worldwide pandemic, and methods to augment exercise benefits are required.
The constrained disorder principle (CDP) characterizes biological systems based on their
inherent variability. Therefore, we aimed to investigate the association between intra-individual
variability in PA and disability among non-athlete adults.

Methods:

In this retrospective analysis of the longitudinal SHARE survey, we included non-disabled
adults aged >50 with at least six visits over 14 years. Self-reported PA frequency was documented
bi- to triennially. Low PA intensity was defined as vigorous PA frequency less than once a
week. Stable PA was described as an unchanged PA intensity in all consecutive middle observations.
The primary outcome was defined as a physical limitation in everyday activities at the end
of the survey. Secondary outcomes were cognitive functions, including short-term memory, longterm
memory, and verbal fluency.

Results:

The study included 2,049 non-disabled adults with a mean age of 53 and 49.1% women.
In the initially high PA intensity group, variability in PA was associated with increased physical
disability prevalence (23.3% vs. 33.2%, stablevs.unstable PA; P<0.01; adjusted P<0.01). In the initially
low PA intensity group, variability was associated with a reduced physical disability (45.6%
vs. 33.3%, stablevs.unstable PA; P=0.02; adjusted P=0.03). There were no statistically significant
differences in cognitive parameters between the groups. Among individuals with the same low PA
intensity at the beginning and end of follow-up, variability was associated with reduced physical
disability (56.9% vs. 36.5%, stablevs.unstable PA; P=0.02; adjusted P=0.04) and improved short-
-term memory (score change: -0.28 vs. +0.29, stablevs.unstable PA; P=0.05).

Conclusion:

Incorporating variability into PA regimens of inactive adults may enhance their physical
and cognitive benefits.
Enhancing Quality Standards: A Critical Evaluation of Genuine Cyclodextrin-Containing Products in the Post-Soviet Market
Authors: Puskás Istvan , Nebalueva Anna , Botnar Anna , Muravev Anton , Shityakov Sergey
Published: January 2025

This study addresses suboptimal formulation practices observed in cyclodextrin (CD)-
containing medicinal products within the post-Soviet region, particularly in Russia, where CDs are
often used in amounts significantly lower than stoichiometric amounts. By analyzing ten products
using transparent package inserts, this research underscores the unique transparency observed in
the composition information of medicinal products within the post-Soviet region. This study highlights
the importance of justifying cyclodextrin quantities in formulations and recommends thorough
evaluation by the Ministry of Health for marketing authorization. The exceptional transparency
observed in the post-Soviet region enables increased awareness among physicians, patients,
and healthcare professionals regarding exposure to inactive ingredients and their functionality.
This transparency provides valuable insights into optimizing the use of cyclodextrins in pharmaceutical
formulations.
FLUID FLOW CHARACTERISTICS IN A SHELL AND TUBE HEAT EXCHANGER WITH SWIRL BAFFLES
Authors: Rahman Aulia , Winarto Winarto , Siswanto Eko , Yulianti Lilis , Kusumastuti Rizky
Published: January 2025

This paper presents a numerical investigation into the fluid flow and heat transfer characteristics of a shell and tube heat exchanger (STHeX) equipped with baffles that induces swirl flow. A Computational Fluid Dynamics (CFD) model was created to simulate the STHeX behavior, and its accuracy was confirmed by comparing it to the Bell-Delaware method results. The two sets of calculations exhibited good agreement, validating the CFD model. The velocity component of the fluid flow was analyzed both qualitatively and quantitatively. The flow patterns of eddies on the STHeX were carefully examined and their correlation with thermal performance was investigated. This study demonstrates that the swirl flow baffle geometry leads to a more turbulent flow pattern, resulting in an increase in the overall heat transfer coefficient. The findings indicate that the swirl flow baffle enhances heat transfer performance and reduces pressure drop in comparison to a conventional STHeX.
ANALYSIS OF EFFECTIVENESS OF STATIONARY LIFT NET AND FLOATING LIFT NET OPERATION IN PROBOLINGGO WATERS
Authors:   Universitas Brawijaya, Rihmi Mihrobi Khalwatu ,   Research Group IM FISHER FPIK UB, Isdianto Andik ,   Universitas Brawijaya, Wardhani Mentari Puspa ,   Universitas Brawijaya
Published: January 2025

Lift net is a fishing tool that belongs to the lifting net group. In terms of construction, there are two types of lift net, namely: stationary lift net and floating lift net. Stationary lift net are a type of static fishing gear. The advantage of this fishing gear is that it gives fishermen certainty about the fishing location. However, if fishermen are not wise in exploiting fish, the catch will decrease, the reason is that stationary lift net will rely heavily on the stock/abundance of local fish in these waters. This is different from floating lift net which are able to change positions. The method is to pull the lift net with the help of the boat. Usually fishermen will move the position of any lift net when the catch is low or the weather is bad. Thus, research was carried out regarding the effectiveness and efficiency of the operation of the lift net by conducting experimental fishing in Probolinggo waters. The results of the independent t test show a significance value of 0.152, which means there is no difference in catches between the stationary lift net and the floating lift net.
Metric Dimension of Banded-Turán Graph
Authors: Huda Muhammad Nurul , Hartono Hartono
Published: January 2025

Given a graph G=(V(G),E(G)). Let S={s1,...,sk} be an ordered subset of V(G). Consider a vertex x, a coordinate of x with respect to S is represented as r(x|S)=(d(x,s1),...,d(x,sk)) where d(x,si) equals the number of edges in the shortest path between x and si for i=1,...,k. The minimum value of k such that for every x has distinct coordinate is called metric dimension of G. Turán graph T(n,r), n=r=2  is a subgraph of complete r-partite graph on n vertices having property that the difference of cardinality of any two distinct classes is at most one. In this paper, we build a new graph namely a banded-Turán graph, BT(n,r,m), as a graph built by a Turán graph T(n,r) and r uniform path graphs Pm in which every vertex of each class of T(n,r) connected to an initial vertex of corresponding path graph Pm. Intuitively, this graph illustrates as if a Turán graph is banded by r uniform ropes. We determine some basic graph properties including independence number, chromatic number, and diameter of banded-Turán. The main result in this paper is we obtain that the metric dimension of banded-Turán turns out that it depends on the number of its classes. If it has two classes then the metric dimension is equal to n-1 and if it has more than two classes then the metric dimension is equal to the metric dimension of Turán graph included in it.
Students' Metacognition in Solving HOTS Questions in the Context of the Flag Ceremony Yard Based on Initial Mathematical Abilities
Authors: Murtafiah Wasilatul , Yunitasari Anisa , Gembong Sardulo , Alvarez Joel I. , Yahya Faridah Hanim
Published: January 2025

This study aims to determine the ability of metacognition in solving HOTS problems in the context of problem related to activities in the context of the flag ceremony yard in solving problems based on initial mathematics ability. This research approach was descriptive qualitative involving 3 students as research subjects who were selected based on high, medium, and low initial mathematics abilities. The data were validated by using method triangulation techniques, namely tests and interviews. The results showed that students with high initial mathematics ability showed good metacognition skills in solving HOTS problems in planning, monitoring, and evaluating activities. However, they still need to improve their ability to evaluate the repair strategy if there is an error. Students with medium initial mathematical ability showed good metacognition skills in several aspects but needed to improve some aspects. Students with moderate mathematics ability have a good basic understanding of metacognition in planning activities. However, they need to improve their metacognition skills in monitoring and evaluating when solving HOTS problems. Meanwhile, students with low initial mathematical ability show limitations in utilizing metacognition skills in planning, monitoring, and evaluating activities, as a result, students experience difficulties in solving problems. So, teachers need to design teaching materials that can improve students' mathematical abilities and metacognition.
Eksplorasi rumah adat mekongga sebagai konteks pembelajaran matematika
Authors: Wangsa Arma , Marniati Marniati , Umasugi Sitti Mutia
Published: January 2025

Pembelajaran matematika di sekolah masih cenderung menggunakan konteks-konteks yang kurang dipahami secara mendalam oleh peserta didik. Oleh karena itu, inovasi konteks dalam pembelajaran matematika sangat diperlukan, salah satunya dengan menggunakan rumah adat sebagai representasi geometri yang dekat dengan kehidupan sehari-hari. Penelitian ini bertujuan untuk mengeksplorasi rumah adat Mekongga di Kabupaten Kolaka sebagai konteks pembelajaran geometri. Metode kualitatif deskriptif digunakan dalam penelitian ini untuk mengeksplorasi replika rumah adat Mekongga. Eksplorasi dilakukan dengan memilih dua informan secara purposive, yaitu masyarakat dan pakar budaya Mekongga. Data dikumpulkan melalui observasi dan wawancara, kemudian dianalisis untuk menemukan konsep-konsep matematika yang terkandung dalam desain rumah adat tersebut. Hasil penelitian menunjukkan bahwa rumah adat Mekongga dapat diintegrasikan sebagai konteks pembelajaran geometri di sekolah, khususnya pada konsep bangun dua dimensi, seperti segitiga, kesebangunan segitiga, persegi, persegi panjang, dan belah ketupat. Selain itu, konteks ini juga relevan untuk digunakan dalam kegiatan pembelajaran konsep transformasi geometri, mencakup refleksi, rotasi, dan translasi, serta pengenalan bangun tiga dimensi seperti balok dan prisma segitiga. Dengan demikian, menggunakan rumah adat Mekongga sebagai konteks pembelajaran tidak hanya memperkaya konteks materi matematika, tetapi juga memperkenalkan nilai-nilai budaya lokal kepada peserta didik.
Case-Study: Unethical Practices leads Un-Natural Death of Handicraft Products
Authors: Dilip Kumar  , P.V. Rajeev
Published: January 2025

The given case study discusses about the burning issues of the handicraft sector. As we know that the handicraft was a key sector in ancient time regarding employment generation, foreign exchanges, and expertise in unique crafts. The case study highlighted some fiery issues of handicraft sector which created hurdles against growth and development of sector.
Parental Technoference and Child Problematic Media Use: Meta-Analysis
Authors: Zhang Jinghui , Zhang Qing , Xiao Bowen , Cao Yuxuan , Chen Yu , Li Yan
Published: January 2025

Background

Parental technoference, the interruption of parent-child interactions by technology, has been associated with negative outcomes in children’s media use. However, the magnitude of this relationship and its moderating factors remain unclear.

Objective

This study aims to systematically examine the relationship between parental technoference and child problematic media use, as well as to identify moderating factors such as age, parental technoference group, study design, and type of problematic media use.

Methods

Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a comprehensive literature search was conducted up to August 2024 across multiple databases, including Web of Science, EBSCO, ProQuest, PubMed, PsycINFO, and China National Knowledge Infrastructure, using predefined search strings. A total of 53 studies with a total of 60,555 participants (mean age of 13.84, SD 1.18 years) were included. Inclusion criteria comprised studies involving children under the age of 22 years, assessing the association between parental technoference and child problematic media use with valid measures, and reporting necessary statistical data. Exclusion criteria included studies focusing on other child outcomes, having sample sizes <30, or being case reports or review papers. The risk of bias was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. A random-effects meta-analysis was performed using R (version 4.2.1; R Foundation for Statistical Computing) with the meta and metafor packages to evaluate the association and conduct moderator analyses.

Results

The meta-analysis identified a significant positive association between parental technoference and child problematic media use (r=0.296, 95% CI 0.259-0.331). Moderator analyses revealed that both parental technoference group (P<.001) and study design (P=.008) significantly influenced this relationship. Specifically, the association was stronger when both parents engaged in technoference compared to when only 1 parent did, and in cross-sectional studies compared to longitudinal studies. Age, gender, publication status, and type of problematic media use did not significantly moderate the relationship (all P>.05).

Conclusions

This meta-analysis provides robust evidence of the association between parental technoference and child problematic media use. The findings highlight the need for family-based interventions and underscore the importance of longitudinal research to understand the temporal dynamics of this relationship better.

Trial Registration

PROSPERO CRD42023471997; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=471997
Attitudes of German General Practitioners Toward eHealth Apps for Dementia Risk Reduction: Qualitative Interview Study (Preprint)
Authors: Schultz Adrian , Luppa Melanie , Bleckwenn Markus , Riedel-Heller Steffi G , Zuelke Andrea
Published: January 2025

BACKGROUND

eHealth interventions constitute a promising approach to disease prevention, particularly because of their ability to facilitate lifestyle changes. Although a rather recent development, eHealth interventions might be able to promote brain health and reduce dementia risk in older adults.

OBJECTIVE

This study aimed to explore the perspective of general practitioners (GPs) on the potentials and barriers of eHealth interventions for brain health. Understanding the perspective of GPs allows us to identify chances and challenges for implementing eHealth apps for dementia risk reduction.

METHODS

We conducted semistructured expert interviews with 9 GPs working in an outpatient setting in and near Leipzig, Germany. Data were fully transcribed and analyzed using a process model of qualitative content analysis with codes and categories being constructed inductively and deductively.

RESULTS

We found generally favorable but balanced views of eHealth apps for brain health. Eight themes were identified and elaborated on in the data as follows: “addressing dementia,” “knowledge about dementia,” “need for information,” “potential for prevention,” “chances for apps for prevention,” “development of apps for prevention,” and “barriers of apps for prevention.” GPs talked mostly about how and when to address dementia and the requirements for their use of eHealth apps for dementia prevention. GPs stated that they only addressed dementia once abnormalities were already present or less frequently when a patient or relative expressed a direct wish, while individual dementia risk or standardized diagnostic during routine check-ups were mentioned much less frequently. According to GPs, knowledge about dementia in patients was low; therefore, patients expressed little need for information on dementia risk factors and prevention in GP practices. Most patients wished for quick information regarding diagnostics, treatment options, and progression of the disease. GPs mentioned a lack of overview of the available eHealth apps and their content. They also expressed a fear of inducing health anxiety when talking to patients about risk factors and prevention.

CONCLUSIONS

GPs want patients to receive relevant and individualized information. Prerequisites for the use of eHealth apps for dementia prevention were app characteristics related to design and content. GPs need to address dementia more routinely, assess relevant risk factors, and aid patients in a preventive role. Concerns were expressed over limited effectiveness, overwhelming patients, limited use in clinical practice, and only targeting patients with an already low risk of dementia.
Crisis Text Line and Loris.ai Controversy Highlights the Complexity of Informed Consent on the Internet and Data-Sharing Ethics for Machine Learning and Research (Preprint)
Authors: Eysenbach Gunther
Published: January 2025

UNSTRUCTURED

.
The Impact of COVID-19 on Story Retelling and Verbal Working Memory in Young Adults: A Comparative Study (Preprint)
Authors: Yoo Hyunsoo
Published: January 2025

BACKGROUND

The impact of COVID-19 has primarily been studied in the context of language delays or developmental disorders in infants and children. However, the effects on young adults have received less attention. COVID-19 not only affects physical health but also cognitive and language functions, which is an emerging area of research. While previous studies have focused on developmental stages, the effects of COVID-19 on the language abilities of healthy young adults remain underexplored. This study aimed to investigate the impact of COVID-19 on the spoken language, particularly in story retelling and working memory, in young adults.

OBJECTIVE

The objective of this study was to assess the effects of COVID-19 on spoken language abilities, particularly story retelling and working memory, in young adults. The study sought to understand how COVID-19 might influence the spoken discourse abilities of young adults, and whether these effects are temporary or long-lasting.

METHODS

The study involved 77 young adult participants, of whom 39 were in the non-COVID group and 38 were in the COVID group. Participants underwent the Story Retelling Procedure (SRP) and working memory tests. The SRP test, which heavily relies on auditory comprehension and memory, was used to evaluate the impact of COVID-19 on spoken discourse. Working memory was also assessed to examine potential COVID-related disruptions in cognitive functions.

RESULTS

The results revealed a significant reduction in performance on the SRP test in the COVID group compared to the non-COVID group. The mean score for the COVID group was 5.67 (SD = 2.01), while the non-COVID group’s mean was 7.15 (SD = 1.78), with a statistically significant difference (p = 0.03). This suggests that COVID-19 had a negative impact on the ability to retell stories. However, no significant differences were found in working memory performance between the two groups (p = 0.45), indicating that working memory was not notably affected by COVID-19 in this sample.

CONCLUSIONS

COVID-19 was found to negatively affect spoken discourse, particularly story retelling abilities, in young adults, although it did not impact working memory. The findings suggest that COVID-19 may cause temporary disruptions in language abilities in healthy young adults, with implications for future studies on long-term effects, particularly regarding long-COVID symptoms. Further research is needed to explore the lasting impact of COVID-19 on language processing, especially in individuals experiencing persistent symptoms.
Developing a National Strategy for Digital Mental Health in Ireland: A Reflexive Thematic Analysis of a Stakeholder Engagement Process. (Preprint)
Authors: Kennedy Sarah , Fitzgerald Robyn , Melia Ruth
Published: January 2025

BACKGROUND

The World Health Organisation recommends integrating digital technologies into mental health care, underscoring the need for countries to develop national digital mental health strategies to guide efforts. In Ireland, the national Digital Mental Health (DMH) Specialist Group brought together key stakeholders in DMH research, practise, and lived experience, to develop ‘A Shared Vision for Digital Mental Health in Ireland’.

OBJECTIVE

The current study aimed to explore the views of DMH stakeholders to set priorities for the development of a DMH strategy.

METHODS

47 stakeholders were each assigned to one of six focused strategy discussion groups. Invited stakeholders included experts in DMH research, clinical practise, mental health advocacy and policy, together with those with lived experience of accessing mental health services. Qualitative data was analysed using a reflexive thematic analysis approach. Researchers followed Braun and Clarke's 6-step framework.

RESULTS

Five major themes were identified; Inclusive Access, User-led, Trust, Education and Training, and Connectedness. Major themes related to 15 sub-themes. Inclusive Access comprised of inclusivity, accessibility and early intervention. User-led encompassed co-production, choice, and needs-led. Compelling narrative, regulation, policy and governance, and evidence-base were identified within the theme of Trust. The sub-themes of digital literacy, mental health literacy and transformation were identified within Education and Training. Finally, Connectedness incorporated the sub-themes of integration, relationships, and stigma.

CONCLUSIONS

Overall, delegates viewed digital technology as a potential enabler of accessible and inclusive mental health support. The need for policy to address concerns regarding privacy, further education and training needs, regulation, and a robust evidence base were raised. Co-production at all stages was identified as key to reducing access barriers and enhancing inclusion. Themes identified were used to inform the development of the first national DMH strategy in Ireland. Further research will involve a consensus seeking process to refine and prioritise actions to guide implementation planning.

CLINICALTRIAL

Not applicable.
Application of Humic Acid and Mulch Dose on Corn (Zea mays L) Yield
Authors: Pratama Bama Wida , Budi Luluk Sulistiyo , Puspitawati Indah Rekyani
Published: January 2025

This research aims to determine whether there is an interaction between the use of humic acid and mulching on the growth and production of corn plants, the effect of humic acid on the growth and production of corn plants and the effect of the use of mulch or mulching on the growth and production of corn plants. This study used a Randomized Block Design (RAK) with 3 replications in Giripurno Village, Kawedanan District, Magetan Regency. The first factor studied was humic acid (A) consisting of 3 treatments, namely doses of 0 Kg / Hectare, 10 Kg / Hectare, 20 Kg / Hectare and the second factor was mulch (M) consisting of 3 treatments, namely without mulch, plastic mulch, straw mulch. The parameters observed included plant height, stem diameter, number of cobs, weight of wet cobs with husks, weight of wet corn cobs without husks, weight of 1000 grains, number of rows, number of seeds, dry weight without husks, weight of dry husked corn, number of leaves, leaf area. There is interaction with plants on the parameters of yield, namely the weight of wet cobs with husks, weight of 1000 grains, and number of rows because the nutrients in humic acid can provide benefits to the yield of corn plants. The absence of interaction on the parameters of plant height 53 HST, stem diameter, number of cobs, weight of wet cobs without husks, number of seeds, dry weight of whole cobs, weight of dry kernels, number of leaves, leaf area is caused by insufficient dosage and short sample observation time.
Silicato de calcio como recubrimiento pulpar indirecto bajo restauraciones directas posteriores
Authors: Saravia Rojas Miguel Ángel , Torres Ramirez Jesely , Huanambal Tiravanti Victor Abel , Geng Vivanco Rocio
Published: January 2025

Introducción: en la búsqueda de enfoques conservadores para tratar lesiones cariosas profundas, se ha propuesto el recubrimiento pulpar. La técnica tiene como objetivo detener la progresión de la caries y promover la formación de dentina reparadora. Entre las opciones disponibles, se destacan los liners a base de silicato de calcio, materiales bioactivos que favorecen la formación de apatita carbonatada. Objetivo: presentar un caso clínico en el que se empleó un liner a base de silicato de calcio modificado con resina. Presentación del caso: paciente masculino de 22 años que acude a la clínica dental docente de una universidad en Lima, Perú. El examen clínico y radiográfico reveló la presencia de lesiones cariosas profundas en los dientes 46 y 47. Después de la remoción del tejido infectado por caries, se aplicó un liner a base de silicato de calcio modificado con resina sobre la dentina próxima a la cámara pulpar. Posteriormente, las cavidades fueron restauradas utilizando un sistema adhesivo autograbable, resina fluida y compuesta. Se tomaron fotografías clínicas intraorales y radiografías dentoalveolares luego de un año. No se reportó dolor ni signos de reabsorción interna o externa, tampoco lesiones periapicales. Conclusiones: el procedimiento con el liner a base de silicato de calcio modificado con resina utilizado en este caso clínico mostró que es un material apropiado como recubrimiento pulpar indirecto pues no se reportó sensibilidad ni lesiones periapicales luego de un año post operatorio.
Estabilidad del color y la influencia de bebidas cromogénicas
Authors: Flores-Ledesma Abigailt , Rodríguez-Chávez Jacqueline Adelina
Published: January 2025

En los últimos años la odontología ha sufrido un cambio drástico en varios sentidos, hemos cambiado a preparaciones de mínima invasión, gracias a la mejora en los sistemas adhesivos, con ello las preparaciones se han modificado, y se busca en todo sentido preservar la mayor cantidad de tejido dental. En este sentido, los tratamientos dentales en la actualidad requieren en su mayoría protocolos adhesivos que permitan su unión a los diferentes sustratos dentales. Los requerimientos por parte del paciente también han cambiado con el tiempo, la necesidad de una alta estética es prioritaria, no solo en el sentido de que buscan un cambio de forma sino también de color.
Detecting Acute Lymphoblastic Leukemia in Blood Smear Images using CNN and SVM
Authors: Adiwijaya Nelly Oktavia , Ardiansyah Sultan , Swasono Dwiretno Istiyadi
Published: January 2025

Acute Lymphoblastic Leukemia (ALL) is a common and aggressive subtype of leukemia that predominantly affects children. Accurate and timely diagnosis of ALL is critical for successful treatment, but it is hindered by the limitations of manual examination of peripheral blood smear images, which are prone to human error and inefficiency. This study proposes an improved diagnostic approach by integrating the EfficientNet architecture with a Support Vector Machine (SVM) classifier to enhance classification accuracy and address the performance inconsistencies of standalone EfficientNet models. Additionally, a novel CNN-based model with a reduced number of parameters is developed and evaluated. A dataset comprising 3.256 peripheral blood smear images across four classes (benign, early, pre and pro) was used for training and testing. The EfficientNet-SVM models achieved a peak accuracy of 97.35% using the EfficientNet-B3 architecture, surpassing previous studies. The improved CNN model achieved the highest accuracy of 99.18% while reducing parameters by 59.5% compared to the best prior models, with a negligible accuracy decrease of only 0.67%. These findings highlight the potential of combining EfficientNet with SVM and the efficiency of the improved CNN model for automated ALL detection, paving the way for more reliable, cost-effective, and scalable diagnostic tools.
Design and Implementation of Two-phase Boost Inverter using Interleaved Method to Increase Output Current
Authors: Setiyawan Fahrul Indra , Pratomo Leonardus Heru
Published: January 2025

The advancement of technology is rapidly evolving, particularly in the field of electronics, namely power electronics. One of the applications is the use of new and renewable energy. The converters required in new and renewable energy are inverters with good quality and performance. The step-down (buck) inverter is commonly used in this application. Different from the normal inverter, the step up (boost) inverter is proposed to be analyzed, simulated, and implemented in this paper. The proposed inverter uses a two-phase interleaved boost inverter (TP DC-AC IBI) consisting of a full bridge inverter and dual AC-AC interleaved boost converter. The inverter part always converts DC voltage to AC voltage, while the dual AC-AC interleaved boost converter part serves to increase the output voltage. The inverter consists of three arms: the first and second arms are controlled by Sinusoidal Pulse Width Modulation (SPWM) using 180° phase-shifted carrier signal, and the third arm is controlled by a zero-crossing detector.  Pulse Width Modulation (PWM) is used to control dual AC-AC interleaved boost converter. By combining this inverter with dual AC-AC interleaved boost converter, a new topology is created. This study specifically investigated the strategy to control this new topology using current controls. The actual current was obtained by installing an HX-10P current sensor on the output side. The output current was compared with the reference current, and the next stage was controlled using a proportional plus integral controller. The control signals output was modulated using SPWM signals on the inverter side and PWM at the AC-AC interleaved boost converter side to drive many power switches. To guarantee that the desired current control can always be achieved, the actual current and reference current must always match. The proportional plus integral controller was chosen due to its simplicity, high accuracy, and quick response time. The analysis involved verifying simulation tests using Power Simulator (PSIM) software. The hardware implementation was conducted in the laboratory and tested using standardized equipment. A couple of inductors were installed to reduce harmonic current on the output side and obtained THD of 3.3%, which according to the IEEE 519-2014, has met the standard as it was less than 5%. Thus, this new topology can be used in new and renewable energy for its good performance.
Integrating Ensemble Learning and Information Gain for Malware Detection based on Static and Dynamic Features
Authors: Sani Ramadhan Rakhmat , Rafrastara Fauzi Adi , Ghozi Wildanil
Published: January 2025

The rapid advancement of malware poses a significant threat to devices, like personal computers and mobile phones. One of the most serious threats commonly faced is malicious software, including viruses, worms, trojan horses, and ransomware. Conventional antivirus software is becoming ineffective against the ever-evolving nature of malware, which can now take on various forms like polymorphic, metamorphic, and oligomorphic variants. These advanced malware types can not only replicate and distribute themselves, but also create unique fingerprints for each offspring. To address this challenge, a new generation of antivirus software based on machine learning is needed. This intelligent approach can detect malware based on its behavior, rather than relying on outdated fingerprint-based methods. This study explored the integration of machine learning models for malware detection using various ensemble algorithms and feature selection techniques. The study compared three ensemble algorithms: Gradient Boosting, Random Forest, and AdaBoost. It used Information Gain for feature selection, analyzing 21 features. Additionally, the study employed a public dataset called ‘Malware Static and Dynamic Features VxHeaven and VirusTotal Data Set’, which encompasses both static and dynamic malware features. The results demonstrate that the Gradient Boosting algorithm combined with Information Gain feature selection achieved the highest performance, reaching an accuracy and F1-Score of 99.2%.
Performance Comparison of Machine Learning Algorithms for Ikat Weaving Classification
Authors: Hidajat Moch. Sjamsul , Wibowo Dibyo Adi , Mintorini Ery
Published: January 2025

Ikat weaving is a rich traditional heritage of Kota Kediri, Indonesia, with a diverse array of intricate motifs that reflect the cultural richness of the region. As new motifs emerge and information about older designs fades, manual identification becomes time-consuming and difficult. This study leverages machine learning technology, specifically XGBoost, Random Forest, and Neural Network algorithms, to automate the classification of these weaving patterns. The dataset consisted of 600 images, split into 480 images (80%) for training and 120 images (20%) for testing, representing four distinct weaving motifs: "Gumul Weaving, Bolleches Weaving, Kuda Kepang Weaving, and Sekar Jagad Weaving." The study achieves high accuracy, with precision, recall, and F1-score all reaching 100%, underscoring its potential to not only improve the efficiency of motif identification, but also play a crucial role in preserving and promoting Indonesia's cultural heritage. Future research should focus on further optimizing these algorithms and expanding datasets to capture a broader range of ikat motifs. Additionally, enhancing the application of this model can contribute to a deeper understanding and broader appreciation of Kota Kediri’s cultural wealth through digital platforms.
Psychological capital and learning burnout in college students: The mediating role of coping styles
Authors: Liu Fangfang , Xu Fan , Zhang Yelan , Zou Jifan , Ma Yutong , Meng Rong
Published: January 2025

This study explored the mediating effect of coping styles in the relationship between psychological capital and learning burnout. We used a cluster sampling method to recruit 647 college students, who completed the Psychological Capital Scale, the Learning Burnout Scale, and the Chinese
Trait Coping Style Questionnaire. Linear regression analysis was used to explore the role of positive coping and negative coping, and a bootstrapping analysis was used to verify the mediation effect. The results showed that there were negative correlations between learning burnout and psychological
capital, and between positive coping and learning burnout, and that there was a positive correlation between negative coping and learning burnout. In sum, positive coping and negative coping were partial mediators of the relationship between psychological capital and learning burnout. Implications
of the findings are discussed.
ISLAMIC LAW REVIEW OF SHARIA FINANCING SCHEMES AT THE ELECTRIC EMPLOYEE COOPERATIVE OF SUBULUSSALAM CITY, INDONESIA
Authors: Prasetia Agung , Jamhuri  , Yuhasnibar
Published: January 2025

This paper aims to examine three main aspects related to sharia financing at the State electricity company (Perusahaan Listrik Negara PLN) First, what sharia financing is often used in the KOKARLIS cooperative. Second, what are the challenges and obstacles that occur in the management of Islamic financing in cooperatives (KOKARLIS). Third, and how is the legal review in the practice of Islamic financing in cooperatives (KOKARLIS).  To answer these three aspects, this research uses a qualitative approach with a descriptive-analytical method. Data collection is done through primary data obtained through interviews, observation, and documentation, as well as secondary data sourced from related references. The results showed that mudharabah and murabahah contracts are the most commonly used types of financing. However, the lack of understanding of cooperative managers, who are mostly PLN employees, is the main challenge, along with the lack of training related to Islamic financing. From the perspective of Islamic law, practices that are not in accordance with sharia rules have the potential to cause gharar, which is contrary to the principle of justice in muamalah. This research emphasizes the importance of increasing the capacity of cooperative managers through continuous training and education related to the principles and practices of Islamic financing. With a better understanding, it is expected that Koperasi KOKARLIS can eliminate the risk of sharia deviations, increase member confidence, and become a better model of sharia financial management.
ROAD UTILISATION RESTRICTION POLICY IN KOPELMA BANDA ACEH, INDONESIA
Authors: Fitriani Mulkan  , Hajarul Akbar
Published: January 2025

This article aims to identify the road restriction policy in Kopelma Darussalam according to the concept of haqq al-murur and Law Number 38 Year 2004. This research uses a qualitative approach with descriptive analysis method, as well as empirical juridical approach to evaluate the implementation of road utilisation restriction policy in the field. The results showed that, the agreement obtained between Syiah Kuala University and UIN Ar-Raniry regarding the use of road access as community mobility agreed to be reopened and utilised together. However, in this case there are still some access hour limits on the closure of these roads such as Jalan Bayeun, Jalan Hamzah Fansuri, then the intersection of three Jalan Tgk. Chik Pante Kulu, North Sector precisely in front of Mushalla Fathun Mubin. However, the implementation of Syiah Kuala University's policy on road utilisation restrictions in Kopelma Darussalam must consider the balance between individual rights to pass with the greater public interest, in accordance with the principle of haqq al-murur and Law Number 38 Year 2004
Da prática para a teoria e a capacitação para evacuação aeromédica de vítimas de desastres envolvendo agentes químicos, biológicos, radiológicos e nucleares
Authors: Haberland Débora Fernanda , Guilherme Fábio José de Almeida , Kneodler Thais da Silva , Silva Thiago Augusto Soares Monteiro da , Oliveira Alexandre Barbosa de
Published: January 2025

The Brazilian Air Force carries out aeromedical evacuation (EVAM) of victims of disasters involving chemical, biological, radiological and nuclear agents - CBRN). Objective: to carry out a qualitative analysis on training to work in EVAM that involves CBRN agents in the perception of health professionals with real experiences. Method: qualitative, exploratory and descriptive research, carried out through semi-structured interviews. Results: From the sample studied, it was found that the experiences contributed to the review of training to act in new situations. Preparation for action was considered very good in most evaluations, requiring training with specific equipment and PPE. Conclusion: Updating training is important for team safety and effective care. Implications for health and nursing: the role of the nurse researcher/instructor stood out due to the importance of using research to plan the training and preparation of EVAM in crisis situations, which is a new area of   care.
Echoes from the torn down fourth wall - UK version
Authors: Jacob Anderskov
Published: January 2025

The project “Echoes from the torn down fourth wall” aims to build bridges between contemporary-music-as-an-art-form and community singing within songs from the Danish songbook ‘Højskolesangbogen’.
In a hybrid concert format created for the project, within the context of an abstracted approach to intense, improvised concert music, several passages with community singing occur, where the audience sings along in songs they know.
The research process has investigated how to create a musical environment that might bridge the different positions (art music and community singing), how the idea of the listener/spectator can be negotiated within different art domains and how, from a genre perspective, the project can be narrated as a meeting between confirming and destabilising forces.
What is being reimagined in the project is not so much the past itself, and not necessarily established narratives about the past, but rather possible current and future narratives of how we may reinterpret songs from the past – together. What is being revealed is not so much specific perspectives in the past but rather hidden potentials in how a majority cultural assemblage like Højskolesangbogen may be renegotiated.