bluuebunny/crossref_metadata_2025 huggingface dataset:
The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas
Authors: Tufton Nicola , Hearnden Robert J , Berney Daniel M , Drake William M , Parvanta Laila , Chapple J Paul , Akker Scott A
Published: August 2022

Emerging evidence suggests the composition of the tumour microenvironment (TME) correlates with clinical outcome and that each tumour type has a unique TME including a variable population of inflammatory cells. We performed immunohistochemistry on 65 phaeochromocytoma and paraganglioma (PPGL) tumour samples with 20 normal adrenal medulla samples for comparison. The immune cells assessed were macrophages, lymphocytes and neutrophils and we compared the proportion of infiltration of these immune cells with clinical and histopathological factors. There was a higher proportion of immune cells in tumour tissue compared to non-neoplastic adrenal medulla tissue, with a predominance of macrophages. There was a higher proportion of M2:M1 macrophages and T helper lymphocytes in aggressive tumours compared to indolent ones. For SDHB associated tumours there was a higher proportion M2 macrophage infiltration, with higher M2:M1 in aggressive SDHB PPGLs compared to indolent tumours. These data demonstrate that immune cells do infiltrate the TME of PPGLs, confirming that PPGLs are immunologically active tumours. Differences in the TME of PPGLs were observed between aggressive and indolent tumours. These differences could potentially be exploited as an aid to predicting tumour behaviour.
Dissemination and Implementation Science to Advance Health Equity: An Imperative for Systemic Change
Authors: Mcloughlin Gabriella Maria , Martinez Omar
Published: August 2022

Innovations in public health research and evidence-based interventions targeting chronic and infectious diseases are only effective if they reach their target populations. Individuals from low socioeconomic background, racial and ethnic minorities, and sexual/gender minority communities are most susceptible to chronic diseases such as obesity and cancer, and infectious diseases such as HIV and COVID-19. These disparities are driven by social and structural conditions including stigma and discrimination, housing instability and food insecurity. Accordingly, interventions that aim to improve population health must be targeted toward marginalized communities who are often systematically excluded from decision making processes. This article introduces dissemination and implementation science as a key opportunity to advance health equity through integrating measures and metrics that evaluate if an intervention is successful at improving health outcomes in marginalized populations. Implementation science also provides frameworks to help evaluate the key determinants to implementation success which can inform subsequent health outcomes. Examples of how researchers have engaged with community stakeholders are provided, along with ways in which dissemination has gone beyond traditional practices. Finally, ways in which universities can build capacity for implementation science as a means to address health disparities are provided with the goal of improving the translation of research to practice.
Extreme Weather Preparedness for Institutions of Higher Education
Authors: Stolow Jeni , Cloutier Marissa , Amy Freestone  , Kathleen Salisbury
Published: August 2022

BACKGROUND: On September 1, 2021, a tornado touched down at Temple University’s Ambler, PA campus. The tornado, a byproduct of Hurricane Ida, damaged most of the buildings on the campus, destroyed thousands of academic resources and killed hundreds of irreplaceable trees, plants, and natural resources. The purpose of this study was to identify needs among the Ambler campus community, document the impact of the tornado, and capture student, faculty, and staff perceptions toward disaster preparedness, climate change, and lessons learned for future disaster preparedness.
METHODS: Data were collected in partnership with the Ambler campus community. A Rapid Needs Assessment, influenced by the Centers for Disease Control (CDC) CASPER Assessment, was utilized. The needs assessment was comprised of a mixed-method approach via a site visit, an online survey, and in-depth interviews.
RESULTS: A total of 74 survey responses and 20 interviews were collected. Survey and interview respondents included students, faculty, and staff. Findings indicated that participants: felt unprepared for the tornado; experienced a variety of social, professional, mental, and physical impacts; and require additional training, education, and communication for future emergencies and natural disasters.
CONCLUSION: As climate change continues to impact weather patterns, institutions of higher education must prepare for more frequent, more severe, and unprecedented natural disasters. It is time to ensure that (1) campuses have transparent protocols in place for the full spectrum of possible weather events, and (2) that students, faculty, and staff receive comprehensive education, training, and communication about such weather-related events and potential negative outcomes.
Reform des Fit-and-Proper-Regimes nach den Kommissionsentwürfen (CRD VI)
Authors: Wundenberg Malte
Published: August 2022

Die Regulierung und Beaufsichtigung der unternehmensinternen Governance von Banken hat in den letzten Jahren eine bemerkenswerte Entwicklung durchlaufen. Einen wichtigen Baustein bilden die aufsichtsrechtlichen Anforderungen an die Eignung von Mitgliedern von Leitungsorganen auf persönlicher und kollektiver Ebene (Fit-and-Proper-Anforderungen). Die von der Europäischen Kommission vorgelegten Vorschläge für ein neues Bankenpaket vom Oktober 2021 (CRD VI/CRR III) sehen eine breitflächige Harmonisierung des Fit-and-Proper-Regimes für Kreditinstitute vor. Sollten die Gesetzgebungsvorschläge umgesetzt werden, hätte dies profunde Auswirkungen auf die Besetzung von Leitungsorganen sowie Inhabern von Schlüsselfunktionen von Kreditinstituten (key function holders).
The fascinating microbes and their impact on neonatal dogs and cats – A review
Authors: Zakošek Pipan Maja , Podpečan Ožbalt , Mrkun Janko
Published: August 2022

Recent literature data indicate that canine and feline neonates are not born in a sterile environment as it was stated previously. The acquisition, colonisation and maintenance of the early life microbiota of healthy fetuses is a rapidly developing research area. In humans, the natural healthy infant microbiome plays an essential role in health and its assembly is determined by the maternal–offspring exchanges of microbes. Even though this topic is becoming more and more important in dogs and cats, the exact role of the neonatal microbiome is not yet fully known in animals. This review summarises the current knowledge of the normal physiological neonatal microbiome in healthy puppies and kittens.
Comparative study of LDA and PIV methods for flow homogeneity measurements
Authors: Bytčanková Lucia , Rumann Ján , Zubík Pavel
Published: August 2022

In the Hydraulic Laboratory of the Department of Hydraulic Engineering, Faculty of Civil Engineering, Slovak University of Technology in Bratislava the distribution of the flow velocity in a shaft intake structure was investigated on a physical model. The homogeneity of the flow velocity distribution in the intakes of turbines has a great influence on the turbine performance. Modern optical methods, particle image velocimetry and laser Doppler anemometry, were used to measure the flow velocity distribution in the model of the turbine intake. The particle image velocimetry method provides a record of the velocity field, while the laser Doppler anemometry method provides an accurate indication of the velocity at a given point. The flow velocity distributions in the examined profiles were measured by the particle image velocimetry and laser Doppler anemometry methods and the results were compared with each other.
Study on in vitro propagation of \(\textit{Vaccinium myrtillus}\) Linn. via nodal culture method
Authors: Thanh Hang Nguyen Thi , Phuong Hoang Nguyen Thi , Van Khiem Dinh , Xuan Huyen Phan
Published: August 2022

Vaccinium myrtillus Linn. is an imported fruit tree with high economic value. Currently, in Vietnam there has not been any publication on in vitro propagation of the blueberry plant. This study is focused on in vitro propagation of V. myrtillus by nodal culture. The results showed that in vitro shoot growth and proliferation were the best when nodes were cultured on WPM medium supplemented with 0.5 mg/L zeatin, 30 g/L sucrose, 10 g/L agar, pH 5.8 (shoot height 4.24 cm, 1 shoot/explant, 8.60 nodes/shoot). The third nodes to sixth nodes proved to be suitable materials for in vitro propagation of V. myrtillus. The proliferation and growth of shoots on the medium without activated charcoal (plant height 3.92 cm, 1 shoot/explant, 8.60 nodes/shoot) were better than those grown on the medium supplemented with 1 g/L of activated charcoal (plant height 3.64 cm, 1 shoot/explant, 7.90 nodes/shoot). For the in vitro rooting stage, the WPM medium containing 1.0 mg/L IBA, 30 g/L sucrose, 10 g/L agar, pH 5.8 resulted in plant height 5.49 cm, root length 1.42 cm, root formation rate 100%. After transferring the cultivated-tissue Vaccinium myrtillus to the greenhouse, substrate with coconut fibre powder, the results were observed to be plant height 6.94 cm, root length 3.18 cm, survival rate 95%. The plantlet growth increased overtime after 4 months in the greenhouse.
\(\textit{n}\)-alkanol stress-induced cell envelope injury of \(σ^{E}\) promoter in \(\textit{Escherichia coli}\)
Authors: Bui Huong Thi
Published: August 2022

To characterize the cellular stress by n-alkanols with different alkyl chain lengths in Escherichia coli, we investigated how n-alkanols damage cell envelope permeability and whether they enhance the promoter activity of the envelope stress response regulator, σE, by using variants of green fluorescent protein (GFP). By using E. coli cells having GFPuv expressing and localizing in the cytoplasm, the inner membrane, and the periplasm, after exposure to n-alkanols, the fluorescent intensity of GFPuv released from cells was examined. Our data showed that at the similar levels of cell death of about 90–97%, ethanol, a short-chain alkanol, at a concentration of 20% damaged the outer membrane more greatly than the inner membrane, whereas a longer-chain alkanol of pentanol at a concentration of 1.125% damaged both of the outer and inner membranes. Then we investigated the envelope stress response to n-alkanols by σE factor by ratiometric analysis of rpoE promoter activity for the downstream GFPuv expression referenced to that of housekeeping sigma 70 (σ70 ) recognizing lacUV5 promoter for red fluorescent protein (RFP) expression. The results indicated that the relative activity of rpoE promoter by pentanol was much greater than that of ethanol. The degree of its sensitization by rpoE deficiency was much more remarkable for cells treated with pentanol than for those with ethanol. The results suggest that the response of the σE plays a significant role in the membrane integrity and survival of E. coli cells treated with n-alkanols depending on the alkyl chain length of the molecule.
FORMAÇÃO DOCENTE E HABILIDADES SOCIAIS: CONTRIBUIÇÕES DA LICENCIATURA SOB A PERSPECTIVA DISCENTE
Authors: Chaves Nádia Mangabeira , Gontijo Simone Braz Ferreira
Published: August 2022

Este artigo buscou identificar a percepção dos estudantes de um curso de licenciatura em relação às habilidades sociais necessárias ao trabalho docente. Foi analisado o Projeto Pedagógico do Curso (PPC) para compreender sua proposta curricular frente à formação de habilidades sociais específicas à docência e realizadas entrevistas para o acesso às percepções dos estudantes sobre o tema. Os resultados apontam que os estudantes compreendem como habilidades sociais pertinentes à docência o comportamento de motivação, proximidade, acolhimento, empatia, incentivo à reflexão e autonomia. Porém, o curso contribui de modo implícito para a formação dessas habilidades, percepçào corroborada pela análise do PPC e pelas entrevistas.
O alistamento de menores e a disciplina de corpos na Escola de Aprendizes Marinheiros da Paraíba nas primeiras décadas do século XX
Authors: Soares Júnior Azemar dos Santos , Lima Luiz Felipe Soares de
Published: August 2022

Este trabalho tem por objetivo investigar o recrutamento de menores pela Escola de Aprendizes Marinheiros da Paraíba durante a primeira metade do século XX. Desde meados do oitocentos, entre as instituições militares que ocuparam maior destaque no ordenamento da sociedade brasileira, estão as Escolas de Aprendizes Marinheiros. Com a proposta de recolher e profissionalizar crianças pobres, menores órfãos e desvalidos para o futuro corpo da Marinha do Brasil, estas entidades ofereciam instrução militar, náutica e elementar dentro de um regime de internato, cuja essência se amparou na modelagem social e “prevenção” da delinquência. Para tanto, nos debruçamos sobre o Livro de Alistamento de Menores, os Livros de Copiador de Offício, e o Regulamento escolar, para problematizar os discursos que denunciavam as formas de recolhimento de menores, num momento em que registrava-se que a população preferia “[...] que seus filhos pereçam nas trevas e na miséria do que entregá-los ao estado para educá-los na honrosa carreira d’armas”. Nesses termos, entendemos o alistamento compulsório como um mecanismo de adestramento, nos fazendo recorrer ao entendimento de disciplina formulado por Michel Foucault (2018) para entender as formas de controle dos corpos dos aprendizes, a regulação e modificação dos critérios de admissão dos menores nos primeiros anos do vigésimo século. Metodologicamente, nos apropriamos da análise do discurso também proposto pelos escritos de Michel Foucault (2014) na tentativa de perceber os enunciados construídos e sobre eles construir outros discursos.Palavras-chaves: Escola de Aprendizes Marinheiros, alistamento, disciplina.
O professor e o aluno, as múltiplas faces do ensinar e aprender
Authors: Santos Mairiele Paula Carvalho Palma , Baggio Daniel Knebel , Ciufa Maria Aparecida Duarte , Silva Fabio da
Published: August 2022

O estudo apresenta as múltiplas faces do ensinar e aprender. O objetivo é compreender o uso de metodologias ativas e a mudança de Mindset na educação sobre a perspectiva dos principais atores desse processo: Professor e Aluno. A relevância do trabalho está na necessidade de repensar o ensino e aprendizagem. Utilizou-se a aplicação de questionário estruturado com perguntas fechadas direcionado aos professores e aos alunos do Programa Jovem Aprendiz da Faculdade Senac Blumenau, e contou com a participação de 32 professores e 333 alunos matriculados no ano de 2019. Os dados foram coletados a partir de técnica de levantamento com a aplicação de formulário, sendo avaliados com o uso de técnicas quantitativas. Os resultados obtidos indicam uma sinergia entre a percepção dos alunos e dos professores no fazer pedagógico, e a importância e o protagonismos de todos nesse processo.
Tecnologia e mídia interativa como ferramentas eficazes no progresso da educação infantil
Authors: Ferreira Alice Aparecida Costa Turetta
Published: August 2022

O presente artigo apresenta orientações gerais aos professores sobre práticas apropriadas ao desenvolvimento cognitivo, emocional e social de crianças mediante o uso da tecnologia e mídia interativa. Enfatiza que a tecnologia e mídia interativa não devem substituir outras atividades educacionais. Ressalta a importância quanto ao apoio aos profissionais da educação infantil, pois, eles precisam de recursos tecnológicos e de mídias disponíveis, acessíveis, bem como links on-line, para melhorar e aprimorar o uso da tecnologia e mídia interativa. Necessitando exemplificar positivamente como a tecnologia foi selecionada, usada, integrada e avaliada com sucesso em suas salas de aula. No entanto, mais pesquisas são necessárias para entender melhor como as crianças usam e aprendem com a tecnologia e mídia interativa, e seus efeitos em curto prazo.
As Tecnologias da Informação e Comunicação na Educação Profissional e Tecnológica no Estado do Amazonas
Authors: Dávila Kétlen Salvino
Published: August 2022

A Educação Profissional e Tecnológica (EPT) é hoje ofertada à sociedade brasileira através de diversas iniciativas. No estado do Amazonas não é diferente, porém, nos municípios mais afastados da capital, existem dificuldades no acesso a recursos como serviços de internet de qualidade. O presente artigo objetiva caracterizar as potencialidades da prática docente com uso das Tecnologias da Informação e Comunicação na EPT no estado do Amazonas. Assim, recorreu-se a uma pesquisa bibliográfica que apontou a validade da inserção de tecnologias em sala de aula e, dessa forma, sugerem-se caminhos para que recursos tecnológicos que já se fazem presentes no cotidiano da maioria da população da região Norte sejam apropriados para fins educacionais.
Panorama atual da matriz curricular dos cursos técnicos de enfermagem da Rede Federal de Educação
Authors: Adão Schiavon Isabel Cristina , Tarantini Silvestri Kátia Vanessa
Published: August 2022

Objetivou-se analisar a matriz curricular dos cursos técnicos em Enfermagem dos Institutos Federais de Educação, Ciência e Tecnologia verificando se estão alinhadas com o preconizado pelas Diretrizes Curriculares Nacionais para a Educação Profissional de Nível Médio. O estudo foi realizado a partir do acesso à informações dos Institutos Federais de Educação, Ciência e Tecnologia, e os Projetos Políticos Pedagógicos dos cursos e apontou que há uma má distribuição nacional dos cursos técnicos em enfermagem da Rede Federal de Educação e que a maioria estavam alinhados ao prescrito, no entanto, muitos cursos ainda possuíam matrizes curriculares desatualizadas, o que poderia comprometer a qualidade do curso ofertado.
Tecnologias digitais de informação e comunicação e os processos educativos em Moçambique: um estudo centrado em instituições de Educação Profissional e de ensino superior na cidade de Lichinga
Authors: Borges Marleth Maria Zita Benedito Verde , Tavares Andrezza Maria Batista do Nascimento , Tumbo Dionísio Luís
Published: August 2022

Na contemporaneidade a revolução tecnológica coloca os seres humanos a assumirem a posição de nômade em sociedade ubíqua. As Tecnologias Digitais conectadas às redes telemáticas favorecem a ligação, a interação contínua e permanente entre pessoas e lugares, mesmo na condição de mobilidade. Da necessidade de reflexões em torno de integração, uso e acesso às tecnologias digitais em rede destinado aos processos educativos na educação profissional e no ensino superior, da Província do Niassa em Moçambique / África, surge este artigo que se pauta em pesquisa do tipo exploratória e revisão bibliográfica perspectivada na abordagem qualitativa. Os resultados apontam que, a partir do tempo pandêmico, os setores da educação profissional e do ensino superior passaram a ocorrer concretamente a partir de maior integração e utilização pedagógica das Tecnologias Digitais de Informação e Comunicação (TDIC), movimento que exige o alargamento das compêtencias dos atores pedagógicos que passam a se socorrer da inteligência artificial, típica do fenômeno da cibercultura, para desenvolver e enriquecer a atividade de ensino e aprendizagem.
O avanço feminino na educação superior brasileira: perspectivas de gênero, raça e classe
Authors: Santos Ana Paula de Souza , Costa Maria Luísa Furlan
Published: August 2022

A confluência de distintos fatores ocasionou na ampliação do Ensino Superior brasileiro nos últimos cinquenta anos, incluindo o massivo ingresso feminino. Assim, este artigo objetiva traçar um panorama sobre tal cenário, tomando por perspectiva as questões de gênero, raça e classe. Para tanto, lançamos mão de um levantamento quantitativo do período, baseado nos censos nacionais publicados. Também realizamos uma pesquisa bibliográfica de abordagem qualitativa. Concluímos que, apesar das mulheres terem se tornado maioria entre discentes do Ensino Superior no Brasil, há menor expressividade de estudantes negras. Além disso, ainda persiste uma segmentação de gênero por áreas de atuação e, consequentemente, uma maior concentração de mulheres nas áreas de menor remuneração salarial.
Horizontes para uma educação emancipatória: a articulação entre gênero, sexualidade e mundo do trabalho na EPT a partir de uma sequência didática
Authors: Inocêncio João Vitor , Garzoni Lerice de Castro , Marcusso Marcus Fernandes
Published: August 2022

O artigo estuda a Educação Profissional e Tecnológica (EPT) e sua relação com as questões de gênero e sexualidade no contexto do Ensino Médio Integrado. Para compreender como os conceitos de trabalho, educação, gênero e sexualidade são abordados e articulados na formação profissional nessa modalidade de ensino, foram aplicados questionários aos (as) estudantes do 3º ano dos cursos técnicos em Informática e Eletroeletrônica Integrado ao Ensino Médio do Instituto Federal de Educação, Ciência e Tecnologia (IFSULDEMINAS), Campus Poços de Caldas no ano de 2018. A partir da discussão bibliográfica e da análise do material coletado, foi proposta uma intervenção na forma de uma sequência didática, o que gerou a elaboração de um produto educacional como resultado da investigação realizada.
Cientistas Negras na Educação Profissional e Tecnológica: Um Estudo no IFBA
Authors: Conceição Caliane Costa dos Santos , Mota Luiza Matos
Published: August 2022

O artigo apresenta resultados parciais da pesquisa intitulada Histórias de Vida de Docentes Negras na Educação Profissional e Tecnológica do IFBA: E eu não sou cientista? que objetivou investigar como o racismo e sexismo estruturais se interseccionam nas trajetórias de cientistas e atuam como mecanismo de silenciamento das mesmas. O debate sobre gênero é construído a partir de autoras como Pedro (2005); Bento (2006), e ampliando esta discussão para as mulheres negras a partir de Ribeiro (2018). A metodologia é qualitativa e o método adotado é da história de vida, foram utilizados como instrumentos o questionário e a entrevista narrativa. O catálogo construído a partir da pesquisa apresenta as trajetórias de vida das cientistas é permeada por desafios impostos pelas estruturas de dominação.
Além-mar: Estudos franco-brasileiros sobre sexo, gênero e sexualidade na educação profissional
Authors: Bezerra Daniella de Souza , Gemaque Robelania Dos Santos , Maia Robério Nunes
Published: August 2022

Nesta resenha da obra Sexo, sexualidade e gênero na educação profissional no Brasil e na França:  estudos exploratórios, tratamos de apresentar em linhas gerais, aspectos relevantes de estudos e pesquisas potentes de autores franco-brasileiros, que se debruçam sobre as questões de gênero, sexo e sexualidade no campo epistemológico da educação profissional. A obra convida à reflexão sobre as desigualdades existentes na formação de mulheres e estudantes LGBTQI+, as invisibilidades, violências e tensionamentos presentes neste campo de formação. Recomendamos a leitura a estudantes e pesquisadores que pensam a educação profissional e tecnológica na perspectiva da interdependência das relações sociais de classe, gênero, sexo, sexualidade e raça, do combate a todas as formas de desigualdade e compreenda os estudantes em todas as dimensões da vida conforme a proposta de formação humana integral.
Nem Só Azul e Rosa: Diversidade Sexual e de Gênero na Educação Profissional e Tecnológica
Authors: Gemaque Robelania dos Santos , Cavalcanti Natália Conceição Silva Barros , Jesus Jaqueline Gomes de
Published: August 2022

O acesso e a permanência de discentes e trabalhadores da educação fora dos modelos heteronormativos e cisnormativos são preocupações cada vez mais presentes na Educação Profissional e Tecnológica. O presente artigo propõe uma análise contextualizada, a partir de estudo realizado na Escola Estadual Tecnológica Professor Francisco das Chagas Ribeiro de Azevedo EETEPA-CACAU-ICOARACI, que teve como objetivo construir uma prática educativa sobre Gênero e Sexualidade no Ensino Médio Integrado. Conclui-se que a importância dada a Gênero e Sexualidade não é necessariamente acompanhada de práticas que rompam silenciamentos ou tentativas de homogeneizar diferentes identidades de gênero e orientações sexuais no cotidiano escolar.
NANOINDENTATION OF SOFT MATERIALS. ANALYSIS OF THE EXPERIMENTAL FACTORS IN CONSTRUCTING A MATHEMATICAL MODEL
Authors: Izyumov Roman I. , Svistkov A. L.
Published: August 2022

The authors call for attention to the specifics of conducting experiments on nanoindentation of soft materials (elastomers, polymers), the features of the experimental setup, the material itself, the interaction of the material under study with the scanning elements of the setup, and environmental conditions. The paper shows which of them require to be taken into account in mathematical models, and which can be neglected, or can be almost completely compensated for by others. The following topics are considered: influence of cantilever bending and its inclination, humidity, plasticity, and viscosity, probe jump to the surface, determining the radius of the probe tip curvature, plastics, destruction of the sample during double indentation, size (scale) effect, sample drift, preservation of the probe shape before and after the experiment, time-varying surface properties, and surface energy during contact formation. This work is intended both to simplify further research and to focus efforts on solving acute problems.
Correlates and Consequences of an Acute Change in eGFR in Response to the SGLT2 Inhibitor Dapagliflozin in Patients with CKD
Authors: Jongs Niels , Chertow Glenn M. , Greene Tom , McMurray John J.V. , Langkilde Anna Maria , Correa-Rotter Ricardo , Kashihara Naoki , Rossing Peter , Sjöström C. David , Stefánsson Bergur V. , Toto Robert D. , Wheeler David C. , Heerspink Hiddo J.L.
Published: August 2022

Significance Statement

Dapagliflozin reduces the risk of kidney failure in patients with CKD but can result in a reversible acute reduction in eGFR on initiation of treatment. This post hoc analysis of the DAPA-CKD trial found that patients who experienced an acute reduction in eGFR>10% after 2 weeks of treatment with dapagliflozin had slower rates of long-term eGFR decline compared with patients who experienced a less pronounced decline or increase in eGFR. Adverse event rates in patients randomized to dapagliflozin were unrelated to the acute change in eGFR. These data suggest that a modest acute reduction in eGFR on dapagliflozin initiation is not associated with higher rates of CKD progression and should not be a reason to discontinue this therapy in the majority of patients.

Background

Dapagliflozin reduces kidney failure risk in patients with CKD but can result in a reversible acute reduction in eGFR upon treatment initiation. Determinants of this eGFR reduction and its associations with efficacy and safety outcomes are unknown.

Methods

The DAPA-CKD trial randomized 4304 adults with CKD and albuminuria to once-daily dapagliflozin 10 mg or placebo, added to standard care. We prespecified an analysis comparing the effects of dapagliflozin among patients who experienced relative reductions in eGFR (>10% or >0%–10%) or an increase in eGFR from baseline to 2 weeks and assessed long-term efficacy and safety thereafter.

Results

A total of 4157 (96.6%) patients had eGFR data available at baseline and at 2 weeks. In the dapagliflozin and placebo groups, 1026 (49.4%) and 494 (23.7%), respectively, experienced an acute reduction in eGFR >10%. Among patients receiving dapagliflozin, those with an acute reduction in eGFR >10% experienced a long-term eGFR decline of −1.58 ml/min per 1.73 m2 per year compared with −2.44 and −2.48 ml/min per 1.73 m2 per year among those experiencing a less pronounced reduction or increase in eGFR, respectively (P-interaction=0.05). In the placebo group, long-term eGFR decline was −3.27, −3.84, and −3.77 ml/min per 1.73 m2 per year for acute eGFR reduction subgroups of >10%, >0%–10%, or increase in eGFR (P-interaction=0.48). Rates of serious adverse events and adverse events of special interest in patients randomized to dapagliflozin were unrelated to the acute eGFR change.

Conclusions

Among patients with CKD and albuminuria treated with dapagliflozin, an acute reduction in eGFR (from baseline to 2 weeks) is not associated with higher rates of CKD progression.

Clinical Trial registration number: A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease (Dapa-CKD) NCT03036150.
Sex Differences in Age-Related Loss of Kidney Function
Authors: Melsom Toralf , Norvik Jon Viljar , Enoksen Inger Therese , Stefansson Vidar , Mathisen Ulla Dorte , Fuskevåg Ole Martin , Jenssen Trond G. , Solbu Marit D. , Eriksen Bjørn O.
Published: August 2022

Significance Statement

Although more women than men have CKD, more men develop kidney failure. Sex or gender disparities in health status or access to health care, or sex-specific rates of kidney function decline, may explain sex or gender disparities in CKD epidemiology. In this study of a general northern European population, baseline kidney function (GFR measured by plasma iohexol clearance) was lower in middle-aged women than in men, whereas rate of decline in kidney function during aging was steeper among men. Sex disparities in comorbidity or CKD risk factors did not explain the sex differences in kidney function decline rates. This study suggests that sex differences in kidney function and kidney function decline rates may, in part, explain sex and gender disparities in the epidemiology of CKD.

Background

CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood.

Methods

We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by comorbidity or CKD risk factors. In the Renal Iohexol Clearance Survey (RENIS) in northern Europe, we recruited 1837 persons (53% women, aged 50–62 years) representative of the general population and without self-reported diabetes, CKD, or cardiovascular disease. Participants’ GFR was measured by plasma iohexol clearance in 2007–2009 (n=1627), 2013–2015 (n=1324), and 2018–2020 (n=1384). At each study visit, healthy persons were defined as having no major chronic diseases or risk factors for CKD. We used generalized additive mixed models to assess age- and sex-specific GFR decline rates.

Results

Women had a lower GFR than men at baseline (mean [SD], 90.0 [14.0] versus 98.0 [13.7] ml/min per 1.73 m2; P<0.001). The mean GFR change rate was −0.96 (95% confidence interval [CI], −0.88 to −1.04) ml/min per 1.73 m2 per year in women and −1.20 (95% confidence interval [CI], −1.12 to −1.28) in men. Although the relationship between age and GFR was very close to linear in women, it was curvilinear in men, with steeper GFR slopes at older ages (nonlinear effect; P<0.001). Healthy persons had a slower GFR decline, but health status did not explain the sex difference in the GFR decline.

Conclusion

Among middle-aged and elderly individuals in the general population, decline in the mean GFR in women was slower than in men, independent of health status.
Strategies for Promoting Globally Competitive Engineering Education in India
Authors:   Former Professor and HOD, Center for International Affairs National Institute of Technical Teachers Training and Research, Chennai, India,, Vedhathiri Thanikachalam
Published: August 2022

Abstract : In the last ten years, there is a growing chorus of discontent about what is not happing in the engineering education in India. Around 5 % of the engineering graduates are possessing required industry -relevant skills and competencies. All over the world major efforts are being undertaken to transforming the engineering education. Based on the research, it is suggested to improve the performance of the faculty members, their abilities to undertake the globalization of engineering education and digitalization. Further there is a need for improving the faculty development through flexible and blended programs under NITTTRs, NITs, State Technical Universities, modernization of curricula and instructional design and collaboration with the industry and government. The colleges are to network with well performing global universities and collaborate in research and development. There is an urgent need for Institute-Industry-Government Partnership for improving the curriculum, research methods and product innovation. The institutes can review their curriculum through Faculty-Alumni- Industry-Representatives of Entrepreneurs (FAIR) Thanikachalam Vedhathiri Former Professor and HOD, Center for International Affairs National Institute of Technical Teachers Training and Research, Chennai, India, vthani2025@yahoo.in Committee once in a year and make improvements. The engineering students are to be exposed to the problems of the industries and they are to be coached to solve them. Their research work, dissertations have to be industry relevant. Further, the engineering institutes have to plan innovative products as a part of the capstone projects. Ultimately the Indian engineering education has to develop industry relevant competency model which will focus industry relevant skills and competencies. Keywords: Competitive Engineering education, flexible curriculum, blended programs, sponsored research and development projects.
A Multimedia Solution Approach to the Social-learning Problem - A case study of thermodynamics
Authors:   Dept. of Mechanical Engineering, JIT, Bangalore, Sharma K. V. Muralidhar , Krishna Dr. S. G. Gopala ,   Professor and Director, Nagarjuna Group of Institutions., Kapilan Dr. N. ,   Professor and Head, Dept. of Mechanical Engineering, NCET
Published: August 2022

Abstract : Engineering student's absence during the first week of opening of the semester is almost an inevitable social problem. A quasi-experimental study on III semester mechanical-engineering students with a convenient sampling size for the course BTD basic Thermodynamics of VTU is conducted. The objective of the case study is to analyse and evaluate the effectiveness of the multimedia solution approach in solving the social-learning problem. Those who were absent (15) and present (17) are classified under treatment and control group respectively. Control group were taught conventionally and the experimental group were given the content “Basic fundamental concepts” exclusively designed and developed for the case study purpose. A post-test was administered both for the control group and the experimental group. Descriptive statistic (mean, %, sd) and inferential statistic (t-test) is used to analyse the effectiveness of the developed content.The descriptive data analysis (acceptance level 2.1 & 2.3) showed that the developed content was fairly accepted by the experimental group also thought that the contents ware useful (usefulness perception level 2.5 & 2.8) for their course understanding. Multimedia contents in their view helped them in solving thesocial-learning problem of ―course beginning absenteeismǁ. It is interesting to note that the students had a marginal preference to custom built multimedia contents over the open source contents. The t-test reveals that there is no significant different in the post test mean score between treatment group (m = 8) and the control group (m = 12). Keywords ultimedia, Thermodynamics, : Social learning, MOOCs, h-LMS hybrid- Learning Management system, LMS
A Case Study on the Student Centric Course in Engineering Programme leveraging PBL
Authors:   Computer Science and Engineering, Kalasalingam Academy of Research and Education, Tamil Nadu, India, Subramanian R. Raja , Sivapragasam C. ,   Civil Engineering, Kalasalingam Academy of Research and Education, Tamil Nadu, India
Published: August 2022

Abstract: Quantification of the quality of Engineers is a significant parameter contributing to an Industry person in recruiting an Engineering student, a government organization in sponsoring/ funding an entrepreneurial aspect of the student and an esteemed University in granting scholarship for higher education of the student. There is a need to improve the students' technological, communication, entrepreneurial skills during the course of the Engineering education. One such pedagogical technique contributing to student's skills is the Project Based Learning (PBL). Through PBL, students learn the courses instead of merely studying it. The significance of PBL and the consequences of practicing PBL in Engineering education is portrayed in this paper. The approach of PBL practiced in Kalasalingam Academy of Research and Education is explained with a case study of one of the courses, that followed PBL pedagogy. The evaluation pattern, rubrics and the supremacy of PBL over traditional pedagogy methods is estimated. Keywords: Project Based Learning, Assessment Methodologies, Engineering Education, Student Centric Course.
Entrepreneurial Inquisitiveness of Under Graduate Mechanical Engineering Students
Authors:   Research Scholar, Department of Mechanical engineering, Government engineering college, Thrissur, Kerala, India., M Pradeep. , k.p Dr Satish. ,   Professor, Production Engineering, Government Engineering College, Thrissur, Kerala, India.
Published: August 2022

Abstract State-of-the-art technologies have changed engineering education and the manufacturing industry over the past few years. Now, the markets in electronics and information science arena have variety of products and are easily accessible for the customers through e-commerce. Mostly the start-up companies are wont these online platforms for their business. The start-ups have a potential to flourish their products in the market. The number of student's start-ups in the mechanical engineering stream is relatively less when compared to the ones spawned by other engineering streams. Products from pure mechanical engineering stream is less in the market but has a huge potential that is waiting to be explored. Promotion of mechanical based start-ups can be made only by paving the seed of entrepreneurial culture, which has to be sprout among engineering students through the campus start-up activities.This study analyses the entrepreneurial inquisitiveness of under graduate mechanical engineering students in the state of Kerala, India, in terms of their attitude, involvement in entrepreneurialinfluence of Government organizations, barriers faced by the students and the different components behind campus start-ups. A sample of 380 mechanical engineering students from various engineering colleges across Kerala participated in survey through both direct and online methods. The questionnaire for the data collection was prepared based on literature, feedback and market research. A seven-point Likert scale was used to record their responses. The data was analysed using a multiple regression approach, with the Statistical Package for Social Sciences (SPSS). Results from this research are aimed at providing insights to State Governments in their start-up policy, to the Universities in their curriculum revision and to the Higher education department in the states to sire an entrepreneurial ecosystem in the engineering campus. Educated youth have to fortify as an industrialist for the economic growth of their nation. Keywords: Global market, Entrepreneurship, Campus Start-ups, Inquisitiveness, Engineering students.
Enhancing Professional Knowledge and Self-Concept Through Self and Peer Assessment Using Rubric: A Case Study for Pre-Services TVET Teachers
Authors:   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia, Masek Alias Masek , Ismail Affero ,   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia, Nurtanto Muhammad ,   Faculty of Teacher and Training Education, Universitas Sultan Ageng Tirtayasa, 42124 Kota Serang, Banten, Indonesia, Hasim Suhaizal ,   Faculty of Technical and Vocational Education, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia
Published: August 2022

Abstract: Teacher education is aimed at developing reliable and skilled teachers, especially in this rapidly evolving educational environment. The transfer of technology to a boundless environment influences much of the teaching pedagogy in today's education system. While we observe it, the teachers are the ones that create the image of our community. It is therefore necessary for the education system of teachers to prioritize the expertise of teachers in a range of fields, such as content, skills, pedagogy, and technology. This study manipulates the rubric assessment as the intervention of educating the teachers to enhance their professional knowledge and self-concept through self and peer assessment. An experimental using single group with pre-test and post-test has been carried out. Self-concept was assessed by pre-test and post-test using a questionnaire, while professional skills were evaluated on a continuous basis through selfevaluation and peer assessment using the teaching simulation rubric. This is noticed that the student's self-concept was not significantly improved by the application of the strategy. Nonetheless, the results showed a trend of increasing on students' scores withor fluctuating levels, which could be related toindividual performance of professional skills. The implication is that the use of rubric with self and peer assessment practice could expedite students' professional skills development as a teacher. Keywords: Professional Knowledge, Self-Concept, Self and Peer Assessment, Pre-Services, TVET
An exploratory study to identify the important factor of the university website for admissions during COVID-19 crisis
Authors:   Assistant Professor, MIT World Peace University, School of Management (UG) India, Gautam Bapat, , Ravikumar Chitnis ,   Pro Vice-Chancellor, MIT World Peace University, School of Management (UG) India, Shrivallabh Sane ,   Lecturer - BioStatistics, Maharashtra Institute of Mental Health
Published: August 2022

Abstract :Universities have been using various Communications channels for promoting their brand. Chapleo et al. reported that the segment of Higher Education concerning branding is attracting increasing academic investigation. They also reported that scarce work has been done to investigate if universities are using their websites to proficiently communicate their brands. Universities, having very unique characteristics would be able to communicate very proficiently using their websites (Chapleo et al., 2011). In India, the challenge was particularly tough for enrolling the students in the academic year 2020- 21. The lockdown due to the covid-19 pandemic started in March 2020. All the traditional approaches of University marketers were challenged (Rutter et al., 2017). The role of University websites suddenly became very important concerning reaching the prospective students for the upcoming academic year. Universities started experiencing that the singular approach of their efficiency of delivering academic content digitally was the key factor for the admissionsinto the academic year 2020-21. An exploratory study was undertaken to investigate how far Universitywebsites are efficient in playing an important role in the admission decision-making process. Using the snowball sampling method 700 students, newly admitted into the academic year 2020-21 in various universities in Pune city of Maharashtra were approached. 200 responses were found effective for the study. The hypothesis testing yielded the result that a single or both parents earning family had a close association with the University website’s usability towards admission decisions. The factor analysis was done to investigate the most important component on the University website conceded that faculty profiles and the opportunities for the students concerning employability and placements carried great importance towards admission decisions. Keywords: University, Admissions, COVID-19, Website.
Enhancing Software Engineering Learning Environment with Computer Games: A Case Study
Authors:   Associate Professor of Computing College of Engineering and Applied Sciences American University of Kuwait - AUK, Rababaah Aaron R.
Published: August 2022

Abstract : Education gamification has been spreading in various disciplines such as languages, computer programming, medicine, natural languages, engineering, etc. Software Engineering is our interest in this work as we saw an opportunity of contribution to enrich literature and empirical studies in this area. Traditional methods of teaching Software Engineering could significantly benefit from gamification as a complementary component in student learning outcomes. We believe we can provide our students with more effective learning environment in number of aspects including: providing enjoyable practice, immediate feedback, enhancing the sense of responsibility, enhanced engagement and performance real time tracking. In this paper, we will present our case study in adopting a computer game in software engineering course. Further, we will present the results of a course exist survey that shows the responses of 114 participating students. The analysis of the survey showed significant positive impact on number of aspects including: student engagement, learning concepts and critical thinking. The overall mean of positiveresponses was 81.2%. Keywords: Software Engineering Education, Enhancing Learning Environment, Utilizing Games in Learning.
“É gostoso e faz bem”: o passado que (re)encanta em campanhas publicitárias
Authors: Bressan Júnior Mario Abel , Dos Santos Neto Valdemir , Da Silva Barbosa Marina
Published: August 2022

O presente estudo tem como objetivo analisar e discutir a utilização da memória teleafetiva, enquanto estratégia mercadológica, dentro do contexto da publicidade audiovisual contemporânea. Com o mercado competitivo, as empresas se colocam cada vez mais pressionadas em encontrar estratégias com vistas a reter a atenção dos consumidores (KOTLER, KARTAJAYA, SETIAWAN:2018). Portanto, parte-se da premissa que o apelo à memória teleafetiva do consumidor pelas marcas passou-se a ser compreendida como estratégia capaz de criar uma conexão sentimental com os consumidores, além de se configurar como um argumento de persuasão e engajamento. O escopo teórico deste se assenta nas contribuições dos autores basilares dos estudos sobre memória, a partir de Huyssen (2000), Pollak (1992) e Halwbachs (2003). Em relação ao conceito de memória afetiva e teleafetiva, o estudo se inclina nos escritos de Bressan Júnior (2019) e Le Breton (2009). O estudo evidencia que o apelo à memória afetiva do consumidor tem demonstrado ser uma tendência recorrente nas abordagens e práticas mercadológicas, o que carece de novos olhares acerca do seu uso e os efeitos advindos da prática nos consumidores.