bluuebunny/crossref_metadata_2025 huggingface dataset:
ผลของสารเรสเวอราทรอลและออกซิเรสเวอราทรอลต่อการแสดงออกของยีนที่บ่งชี้ความเป็นเซลล์ต้นกำเนิดในเซลล์มะเร็งศีรษะและลำคอที่ถูกเหนี่ยวนำด้วยโคบอลต์คลอไรด์และดีเฟอรอกซามีน
Authors:   , อมรทวีชัย อาทิตย์
Published: August 2023

สารเรสเวอราทรอลและสารออกซีเรสเวอราทรอลเป็นสารในกลุ่มฟิโนลิกคอมพาวน์ ที่มีประสิทธิภาพในการป้องกันและรักษาโรคได้หลากหลายชนิด ซึ่งในงานวิจัยนี้ผู้วิจัยสนใจในประสิทธิภาพการต้านกิจกรรมต่างๆที่เกี่ยวข้องกับโรคมะเร็ง โดยเฉพาะประสิทธิภาพในการทำลายเซลล์ต้นกำเนิดมะเร็งซึ่งเป็นเซลล์ที่เปรียบเสมือนเป็นเมล็ดพันธุ์ไม่ดีที่จะก่อให้เกิดเซลล์มะเร็งได้ ภาวะพร่องออกซิเจนเป็นภาวะที่สามารถเหนี่ยวนำให้เกิดการแสดงออกของยีนบ่งชี้การมีอยู่ของเซลล์ต้นกำเนิดมะเร็ง งานวิจัยนี้มีจุดประสงค์เพื่อต้องการศึกษาว่า สารเรสเวอราทรอลและสารออกซิเรสเวอราทรอลสามารถยับยั้งการแสดงออกของยีนบ่งชี้การมีอยู่ของเซลล์ต้นกำเนิดมะเร็งต่างๆ ภายใต้ภาวะพร่องออกซิเจนได้หรือไม่ โดยในงานวิจัยนี้จะทำการจำลองภาวะเสมือนพร่องออกซิเจนด้วยสารโคบอลท์คลอไรด์ และ สารดีเฟอรอกซามีน ผลการทดลองพบว่าสารโคบอลท์คลอไรด์เหนี่ยวนำให้เกิดการแสดงออกของยีนบ่งชี้การมีอยู่ของเซลล์ต้นกำเนิดมะเร็งชนิด ออกซ์-4 นานอก ซีดี-44 ซีดี-105 และ ซีดี-133 ผลที่ได้ทำการตรวจวัดด้วยเทคนิค RT-PCR ส่วนผลการทดลองของสารดีเฟอรอกซามีนพบว่า สามารถเหนี่ยวนำให้เกิดการแสดงออกของยีน ออกซ์-4 นานอก ซีดี-44 ซีดี-105 และ ซีดี-133 โดยใช้เทคนิค Real-time PCR ในการตรวจวัด ผลของการวัดประสิทธิภาพของสารเรสเวอราทรอและออกซีเรสเวอราทรอลพบว่า สารทั้งสองมีความสามารถในการยับยั้งการแสดงออกของยีนบ่งชี้การมีอยู่ของเซลล์ต้นกำเนิดมะเร็งชนิดต่างๆได้ จากการวัดด้วยเทคนิค Real-time PCR ในการยืนยันผลการทดลองในระดับโปรตีน ทำการตรวจวัดด้วย Flow cytometry พบว่าสารเรสเวอราทรอและออกซีเรสเวอราทรอลสามารถยับยั้งการแสดงออกของ ซีดี-44 และ ซีดี-105 ในระดับโปรตีนได้ จากผลการทดลองจึงสรุปได้ว่าสารเรสเวอราทรอลและออกซีเรสเวอราทรอลมีประสิทธิภาพในการทำลายเซลล์ต้นกำเนิดมะเร็งที่ถูกเหนี่ยวนำด้วยภาวะพร่องออกซิเจนได้
TEORİDE VE PRATİKTE TOTALİTER REJİMLERİN KARAKTERİSTİĞİ
Authors: KAHRAMAN Selçuk
Published: August 2023

Pek çok totaliter rejim açıklamalarının aksine tek parti ve tek ideoloji, tek başına sabit ve daimi bir karakteristik nitelik taşımamaktadır. Eski düzenin yerini; yeni olanı alsa da müdahillik sınırları öylesine belirsizdir ki, totaliter rejimin teorisyenleri ve pratisyenleri kabul etse de etmese de temelde öngörülemezdir. Totaliter rejimlerdeki halk egemenliği söylemi, demokratik kurumların varlığı gibi hususlar, demokrasinin karşısında konumlanma güdüsünü kanıtlayıcı özellikler taşımaktadır. Bu durum, günümüz dünyasındaki yeni görünümlerinin olası olabileceği düşünüldüğünde yalnızca geçmişin değil bugün ve geleceğin yaşamsal konusu olmayı sürdürmeyi mümkün kılmaktadır. Totaliter hedefe yönelik çeşitli projeler mutlak bir inançla yürütülmek, karşı çıkan herhangi bir kimse, kurum ve yapı en ağır şekilde tasfiye edilmek zorundadır. Üstelik belli olduğu iddia edilen nihai ama -nihai olamayan- hedefe ulaşmak için sürekli iç ve dış düşmanları temizlemek, totaliter rejimlerin tarihsel pratiklerinin ve tecrübelerinin sunduğu en önemli karakteristik unsurları ortaya koymaktadır. Bu karakteristik unsurların herhangi birinde zaaf gösteren bir rejim, çoktan “tam totaliteryan” olma vasfını fiilen yitirmiş demektir. Böylece hem totaliter rejimlerin ömürleri gündeme gelecek hem de totaliter rejim tiplemelerinin ortaya çıkışı tabiatıyla kaçınılmaz olacaktır. Bu çalışma, tarihsel pratikler ve tecrübeler ekseninde bugünden geleceğe totalitarizmi tartışmaya açarak genelde tekdüze literatür araştırmaları içerisinde yeni perspektiflere olanak tanıyabilecek bir çaba yürütmektedir. Bu çabayı yürütürken ek olarak kısmen karşılaştırmalı siyaset araştırmalarında özellikle demokrasiler için gerçekleştirilen yöntem izlenmeye çalışılmaktadır. Bu çerçevede iktidarın genellikle kimlerce yönetildiği, hangi yollarla el değiştirdiği, iktidar gücünün nerede dağıldığı ve yoğunlaştığı, kuvvetler arasında denge ve denetleme mekanizmalarının ne durumda olduğu, temel hak ve özgürlüklerin ne şekilde işlediği, devletin iktisadi hayattaki rolü, iktisadi gelişmişlik hakkındaki hususların önemi, bu incelemede totaliter rejimler açısından da yanıtlanmaktadır.
COVID-19 DÖNEMİNDE HAVACILIKTA STRATEJİK YÖNETİM VE UÇUŞ VERİLERİNİN İNCELENMESİ
Authors: ŞAHİN Zekeriya , SÜZEN Ekrem
Published: August 2023

2019 yılının Aralık ayında Çin’in Wuhan kentinde ortaya çıkan COVID-19 salgını günümüz dünyasında hemen her sektörü önemli ölçüde etkilemiştir. Dünya Sağlık Örgütü tarafından pandemi olarak ilan edilen COVID-19, havayolu taşımacılığını da etkilemiştir ve etkilemeye devam etmektedir. 2020 yılı itibariyle dünya ülkeleri tarafından havayolu taşımacılığında çeşitli tedbirler alınmıştır. Bu durum havayolu taşımacılığının, gerek sosyal durumu gerekse ekonomik açıdan etkilenmesine yol açmıştır. SARS salgınından bu yana en büyük salgın hastalık olan COVID-19, sivil havacılıkta insani tedbirlere; maske kullanımına, sosyal mesafe kuralına ve dezenfektan zaruriyetine yol açmıştır. Ayrıca dünya ülkelerinin de etkilendiği gibi Türkiye de sivil havacılık bağlamında etkilenen ülkelerden biridir. Bu çalışmada ise Covid-19 döneminden önce ve sonra uçuş verileri analiz edilmiştir
BIST KONAKLAMA SEKTÖRÜNDEKİ İŞLETMELERİN FİNANSAL PERFORMANSLARININ COPRAS VE WASPAS YÖNTEMLERİYLE ÖLÇÜMÜ
Authors: MEDETOĞLU Batuhan , KAVAS Yusuf Bahadır , ÖZTÜRK Mahmut , TÜRKAY Kaan
Published: August 2023

Turizm, ülkelerin kalkınma sağlamaları açısından önem arz eden sektörlerdendir. Hizmet sektörü olan turizm ile ülkeler, sahip oldukları doğal ve kültürel kaynakların ekonomik bir işleme konu edilerek gelir elde edebilmektedir. Turizm sektörünün gelişimi ve büyümesi, turizm işletmelerinin performanslarını etkilenmektedir. Bu nedenle turizm işletmelerinin finansal performanslarının ölçülmesi ve bu performansların analiz edilmesi önemli bir husustur. Bu çalışmanın amacı, Borsa İstanbul’da (BIST) faaliyet gösteren konaklama işletmelerinin finansal performanslarının ölçülmesidir. Bu ölçüm, COPRAS ve WASPAS yöntemleri kullanılarak gerçekleştirilmiştir. İki farklı yöntemin kullanılarak analiz yapılması, bu yöntemler arasındaki farkın tespit edilmesini sağlayarak hem literatürdeki bilgi birikimine hem de finansal performansa yönelik uygulamalara katkı sağlayacağı hedeflenmekte ve düşünülmektedir. Çalışmanın örneklemi BIST konaklama sektöründe faaliyet gösteren işletmelerdir. Analizdeki değişkenler, 2016-2020 dönemlerine ait finansal tablolardan elde edilen finansal oranlardır. Belirlenen finansal oranlar COPRAS ve WASPAS yöntemleri kullanılarak analiz edilmiştir. WAPSAS yöntemine göre 2017-2021 dönemleri arasında finansal performansı en yüksek işletme TEKTU (2017-2020) ve AYCES (2021) iken COPRAS yöntemine göre 2017-2021 dönemleri arasında finansal performansı en yüksek işletme sırası değişkenlik göstermiştir. Çalışmanın sonucuna göre iki farklı yöntemden elde edilen bulgular tamamıyla aynı olmamakla birlikte tüm sıralamalar göz önüne alındığında benzer sonuçlar gözlemlendiği ve yöntemlerin farklı olmasından dolayı işletmelerin finansal performans sıralamalarının değiştiği gözlemlenmektedir.
DUYGU DÜZENLEME BECERİLERİ VE EVLİLİK DOYUMU ARASINDAKİ İLİŞKİDE ÖZ ŞEFKAT DUYGUSUNUN ARACI ROLÜ
Authors: KURNAZ SÖNMEZ Şenay , TASTAN Nuray
Published: August 2023

Bu çalışmada evli kişilerde duygu düzenlemenin evlilik doyumuna etkisinde, öz şefkatin aracı rolü araştırılmıştır. Yüksek düzeyde öz şefkate sahip olan evli kişiler, duygu düzenlemeyi daha etkin bir şekilde kullanarak evlilik doyumunu artırırlar varsayımı üzerine yürütülen bu araştırmada duygu düzenleme becerilerinin evlilik doyumuna etkisi ve bu etkide öz şefkatin aracı rolü incelenmek istenmiştir. Araştırma, Türkiye’de yaşayan 17-61 yaş aralığında evli ve en az lise mezunu 207 kadın, 193 erkek katılımcı ile gerçekleştirilmiştir. Çalışmada kullanılan veriler Demografik Bilgi Formu, Evlilik Doyum Ölçeği (EDÖ), Bilişsel Duygu Düzenleme Ölçeği (BDDÖ) ve Öz Şefkat Ölçeği (ÖŞÖ) aracılığı ile toplanmıştır. Değişkenler arasında basit regresyon analizi yürütülmüştür. Analizden elde edilen bulgulara göre duygu düzenleme becerileri uyumlu stratejileri; evlilik doyumunu ve öz şefkati pozitif yönde ve anlamlı düzeyde yordarken uyumsuz stratejilerin ise; evlilik doyumunu ve öz şefkati negatif yönde anlamlı düzeyde yordadığı sonucuna ulaşılmıştır. Sonuç olarak duygu düzenleme becerilerinin her iki boyutu içinde öz şefkat denkleme eklendiğinde bağımlı değişkeni anlamlı düzeyde yordayan bağımsız değişkenin yordayıcı etkisi anlamlılığını yitirmiştir. Sonuç itibariyle öz şefkatin duygu düzenleme becerileri ve evlilik doyumu arasında tam aracı değişken olma özelliği taşıdığı bulgusuna ulaşılmıştır. Tüm bu bulgular ilgili literatür ışığında tartışıldıktan sonra araştırmacılara ve uygulayıcılara önerilerde bulunulmuştur.
Quality Control of Herbal Drug (Paxherbal Bitter Tea) Via Thin-Layer Chromatography and Phytoconstituent Analysis
Authors: Owolabi Tunde , Amodu Emmanuel , Danga James
Published: August 2023

The effectiveness of any herbal medication depends on the presence or absence of pharmacologically active phytocompounds. These ingredients are significantly affected by the quality control system espoused during and after manufacturing processes and the operation of such pharmaceuticals. Thin-layer chromatography (TLC) is a quality control parameter suitable to identify and codify substances predicated on their distinctiveness and uniformity, giving an identity for such substances. Paxherbal Bitter Tea is a polyherbal medicine harnessed as an anti-diabetes medicine. This study assessed the distinguishable phytoconstituents present and evolved attribute profiles (TLC) for the herbal (Paxherbal Bitter Tea) to serve as a quality control check during manufacturing for consistency and market identity. Qualitative phytochemical and chromatographic assays were carried out employing standard methodologies. The qualitative test revealed the presence of saponin, steroids, reducing sugar, cardiac glycoside, and terpenoids, and the finger-print chromatograms after progression with n-hexane: ethyl acetate (9:1) flaunted three dissimilar elements under ultraviolet light at 365 nm and five spots, when dotted with 20% methanolic sulphuric acid under visible light. In this study, we developed an identity profile for Paxherbal Bitter Tea via its unique chemical biographies, which can be exercised in verifying the quality and consistency of the herbal product.
Interrogating the essence of literature review to social and management science research in the 21st century
Authors: Tayo Olufade George , Peter Ukpeli , Ilias Aliyu Ozovehe
Published: August 2023

This paper is on Interrogating the Essence of Literature Review to Social Science and Management Science Research in the 21st Century. The explanatory survey research design was used in this paper and the secondary method of data collection was adopted to provide explanation on literature review which is a very important item on social and management science research. There are two challenges facing literature review application in the 21st century and those are the wrong use of literature review and the other one is the temptation by the review to apply outdated literatures, it is based on this that this paper recommends that supervision of writeup is required, so as to help research determine the most favourite type of literature review to be used and researchers and presenters are advise to avoid outdated literature to support their writing, it is also suggested that literature outside ten years should be avoided.
PESTEL Analysis and Porter’s Five Forces as marketing tools to evaluate Morrison’s performance and strategy
Authors: Rashid Chnar Abdullah
Published: August 2023

This research mainly focused on evaluating Morrison’s performance and strategy by using PESTEL analysis and Porters’ five forces. Company’s financial reports and statements have used to achieve information regarding to their strategy in order to reveal whether PESTEL analysis and Porters’ five forces can be applied for improving their performance or not and making comparison with its competitors. Sainsbury concerned as its competitor since, they have almost the same level of revenue and their activities are similar. The results show that this company can apply both methods to improve their performance. More information has been established in this research.
Optimization of culture condition for growth and production of bioactive secondary metabolites by endophytic fungus Thermothelomyces thermophiles XJF-9
Authors:   Samarqand davlat universiteti, Nigora Rustamova
Published: August 2023

In this work aimed to optimize the culture condition of the fungal strain Thermothelomyces thermophiles XJF-9 to increase the growth and production of pharmacological active secondary metabolites. The potent fungus is subjected to optimization in various culture medium and incubation time. The optimized culture medium was Potato Dextrose Broth (PDB) using dextrose as carbon source and incubation time 14 days for the maximum growth and production of bioactive natural compounds by T. thermophiles XJF-9. Moreover, secondary metabolites of crude ethyl acetate extract were investigation melanin content assay and tyrosinase activity. These secondary metabolites are effectively utilized in medicinal and pharmaceutical industry.
APIS MELLIFERA JONSIZ ASALARIDAN SINTEZ QILINGAN XITIN-XITOZAN FIZIK-KIMYOVIY TADQIQOTLARI
Authors:   Samarqand davlat universiteti, Feruza Nurutdinova
Published: August 2023

Annotatsiya: Maqolada biopolimer xitin-xitozan tabiatda tarqalishi, xom-ashyo resurslari va Apis Mellifera jonsiz asalaridan sintez qilingan xitozanning fizik-kimyoviy xossalari o'rganish usullari keltirilgan. Polimerlarning molekular massasi, qovushqoqligi, namligi, deatsetillanish darajasi va tarkibidagi azotlar soni aniqlannish usullari tajribalari va natijalari yoritilgan. Konstantalarni aniqlashda optimal muhitlar tanlangan.
BENZOY KISLOTANING FENILATSETILEN BILAN KATALITIK REAKSIYASI
Authors:   Samarqand davlat universiteti, Parmanov A.B
Published: August 2023

Ishda fenilatsetilenga benzoy kislotaning birikishidan vinil efirini hosil qilish uchun jarayonlar diatsetato-di (2-amino-5-metiltio-1,3,4-tiadiazolo) kobalt(II) ([Co(C3H5N3S2)2(CH3COO)2]] va tetrakis-(2-amino-5-etiltio-1,3,4-tiadiazol)-rux(II) dinitrat
([Zn(C4H7S2)4](NO3)2)kompleksi katalizatorlari ishtirokida amalga oshirilgan.
ТЕМПЕРАТУРНАЯ ЗАВИСИМОСТЬ СКОРОСТИ И ЗАТУХАНИЯ АКУСТИЧЕСКИХ ВОЛН В ГАММА ОБЛУЧЕННЫХ КРИСТАЛЛАХ ФТОРИДА ЛИТИЯ
Authors:   Samarqand davlat universiteti, Ахмеджанов Ф.Р
Published: August 2023

Исследована температурная зависимость скорости и затухания акустических волн в кристаллах фторида лития, облученных 60Со гамма-лучами дозой 8 107 R. Показано, что облучение не влияет на изменение скорости акустических волн в интервале температур от 290 до 440 K. В то же время в температурной зависимости акустического затухания наблюдается максимум, который может быть обусловлен воздействием упругой деформации на распределение точечных дефектов наноразмерного масштаба, возникающих под влиянием гамма облучения.
ИНТЕГРИРОВАНИЕ МОДИФИЦИРОВАННОГО УРАВНЕНИЯ КОРТЕВЕГА-ДЕ ФРИЗА С НАГРУЖЕННЫМИ ЧЛЕНАМИ И ИСТОЧНИКОМ В ВИДЕ СУММЫ
Authors:   Samarqand davlat universiteti, Алланазарова Тазагул
Published: August 2023

Метод обратной спектральной задачи применяется для интегрирования модифицированного уравнения Кортевега де Фриза (мКдФ) с нагруженными членами и источником в виде суммы в классе периодических бесконечнозонных функцией. Выводится эволюция спектральных данных периодического оператора Дирака, коэффициент которого является решением уравнения мКдФ с нагруженными членами и источником в виде суммы. Показано, что сумма равномерно сходящегося функционального ряда построенного с помощью решения аналога системы уравнений Дубровина и формула первого следа действительно удовлетворяет уравнения мКдФ с нагруженными членами и источником в виде суммы.
ИССЛЕДОВАНИЕ СТРУКТУРЫ, ФИЗИКО-ХИМИЧЕСКИХ СВОЙСТВ ВЫБРАННЫХ ОРГАНИЧЕСКИХ И НЕОРГАНИЧЕСКИХ ИНГРЕДИЕНТОВ НА ОСНОВЕ МЕСТНОГО И ВТОРИЧНОГО СЫРЬЯ, ПРИМЕНИТЕЛЬНО К РАЗРАБОТКЕ УГОЛЬНЫХ БРИКЕТОВ
Authors:   Samarqand davlat universiteti, Холмуродова Дилафруз
Published: August 2023

В статье рассматриваются основные свойства органических и неорганических ингредиентов для получения угольных брикетов из местного сырья и отходов производств. Изучены структура, свойства этих ингредиентов. Показано, что все ингредиенты играют основную роль при разработке угольных брикетов.
TERMINAL ATSETILEN SPIRTLARINING OKSIDLANISHI ASOSIDA DIINDIOLLAR SINTEZI
Authors:   Samarqand davlat universiteti, Tirkasheva S.I
Published: August 2023

Molekulasida alifatik, alisiklik va aromatik o'rinbosarlar saqlagan terminal atsetilen spirtlarining oksidlanish bilan boradigan gomolitik birikish reaksiyasi o'rganilgan. Jarayonda katalizator sifatida mis (I) xlorid, ligand sifatida N,N,Nˊ,Nˊ- tetrametiletilendiamin, oksidlovchi agent tetraxlorometan va erituvchi methanol yordamida diatsetilen diollari sintez qilindi. Terminal atsetilen spirtlarining dimerlanish jarayonini boshqarish va nazorat qilishning eng muqobil sharoitlari topilgan hamda reaksiya mexanizmlari taklif etilgan. Sintez qilingan diindiollari identifikatsiyalangan va ularning fizik-kimyoviy xossalarini o'rganilgan.
LAGRANJ KO`PAYTUVCHILARI YORDAMIDA TENGSIZLIKLARNI ISBOTLASH
Authors:   Samarqand davlat universiteti, Bobomurod Abdurakhmonov
Published: August 2023

Xalqaro Matematika Olimpiadalarida tengsizliklarni isbotlash alohida o`rin tutadi. Bu kabi tengsizliklarni isbotlashning turli usullari mavjud bo`lib, ushbu maqolada ishlatilishi sodda va qulay hisoblangan Lagranj ko`paytuvchilari yordamida tengsizliklarni isbotlash keltirilgan.
INVARIANT ESTIMATES FOR GENERALIZED OSCILLATORY INTEGRALS WITH POLYNOMIAL PHASE
Authors:   Samarqand davlat universiteti, I.A Ikromov
Published: August 2023

In this paper we consider the problem on uniform estimates for generalized oscillatory integrals given by Mittag- Leffler functions with the polynomial phase. We obtain invariant estimates for corresponding integrals.
GLOBAL IQLIM O‘ZGARISHLARI SHAROITIDA O‘ZBEKISTONDA YUQUMLI-PARAZITAR KASALLIKLAR TARQALISHINING HUDUDIY JIHATLARI
Authors:   Samarqand davlat universiteti, Komilova N.K
Published: August 2023

Ushbu maqolada yuqumli-parazitar kasalliklar orasida ichak infeksiyalarininng (ich terlama, paratif, salmonellyoz, dizenteriya) tahliliga alohida e'tibor berilgan. Yuqumli-parazitar kasalliklar mamlakatimizda 2000-yilda har 100 000 aholiga 1400,6 kishini tashkil qilgan bo'lsa, 2021-yilga kelib bu raqam 2076,6 kishiga ortgan. Ushbu kasalliklarning yuqish ehtimolligi boshqa yuqumli kasalliklarga qaraganda ancha yuqori turadi. Mazkur xastalikning ham boshqa kasalliklar singari hududiy tarkibi ancha keng areallarni egallaydi.
Humanized FoxP2 and the timing of habits
Authors: Brembs Björn
Published: August 2023

Last week, Elizabeth Pennisi asked me to comment on the recent paper from Schreiweis

et al.

entitled “Humanized FoxP2 accelerates learning by enhancing transitions from declarative to procedural performance”. Since I don’t know how much, if anything, of my answers to her questions will end up in her article, I thought I might expand my answer into a post about this very interesting work.
Why this GlamMag will likely not ask for my review again
Authors: Brembs Björn
Published: August 2023

I really loathe reviewing for GlamMagz for two main reasons. For one, it’s hard to remain neutral: publication of a paper in my field in such a journal is beneficial both for the field and for the young people who are authors on this paper. Second, the demands of some of my colleagues so often make my blood boil. At that point I’m very happy these reviews are anonymous and I really don’t want to know the names of these colleagues.
The Drosophila FoxP gene is necessary for operant self-learning
Authors: Brembs Björn
Published: August 2023

See this post with the associated press releases on brembs.net. The Forkhead Box P2 (FOXP2) gene is well-known for its involvement in language disorders. We have discovered that a relative of this gene in fruit flies, dFoxP, is necessary for […] ↓ Read the rest of this entry...
Teaching with Qualitative Data: An Example
Authors: Karcher Sebastian
Published: August 2023

Teaching with Qualitative Data: An Example Sharing qualitative data produces many benefits: shared data can contribute to making the research product in which they were originally deployed more easily understandable and interpretable, they can be analyzed by other researchers, and they can be used for pedagogical purposes. QDR is very interested in promoting all of these uses of shared data.
Presupuesto por resultados en el Perú: Una herramienta de modernización del Estado
Authors: Toledo Meza Erika Esmeralda
Published: August 2023

El artículo analiza los avances del presupuesto bajo el enfoque a resultados en el Perú, un instrumento clave en la modernización del estado replicado de las experiencias de los países desarrollados, para lo cual se utilizó artículos de investigación, fuentes normativas, datos estadísticos y consulta amigable del Ministerio de Economía y Finanzas-MEF. El Presupuesto por Resultados en el Perú se implementó desde el año 2008 iniciando con cinco (05) programas presupuestales y a lo largo de los años fue creciendo hasta llegar en el año 2022 a 90 programas presupuestales. Los resultados permiten visualizar avances significativos en los niveles de asignación bajo el enfoque de presupuesto por resultados. Asimismo, se analizó a tres (03) programas presupuestales de mayor trascendencia a través de la evolución de indicadores, cuyos resultados arrojan un avance progresivo en forma lenta en los indicadores de medición; los diversos estudios demuestran que el presupuesto por resultados tiene una influencia en la eficacia y eficiencia del gasto público.
Who were we? Exploring French past group prototypes
Authors: Maoulida Haifat , Urdapilleta Isabel , Collange Julie , Tavani Jean Louis
Published: August 2023

Groups have cognitive existence through the prototype of the group (Haslam et al., 1995; https://doi.org/10.1002/ejsp.2420250504). Past group prototypes then refer to the most representative characteristics that define the group in these previous states. We suppose, as collective events might have different versions associated with different valences (Zaromb et al., 2014; https://doi.org/10.3758/s13421-013-0369-7), this might also be the case for prototypes also held in the collective memory (Halbwachs, 1950; http://dx.doi.org/doi:10.1522/cla.ham.mem1). After highlighting different facets of the past (Study 1) or not (Study 2), we used the “free association method” (Lo Monaco et al., 2017; https://doi.org/10.1111/jtsb.12124; Vergès, [1992], L’évocation de l’argent. Bulletin de Psychologie, 45(4–7), 203–209). Yet, this research explored the content of past prototypes associated with different elements of French collective memory: the French during the Second World War (Study 1, N = 301), and French people in 18th century (Study 2, N = 354). Results suggest the existence for each of these periods of a “two-sided” prototype, i.e., a positive vs. negative-valence prototype. The implications of the existence of these “two-sided” prototypes, the implication of collective continuity perceived for each of them and avenues for future research will be discussed.
ENHANCING SUSTAINABILITY ASSESSMENT OF BRIDGES IN AGGRESSIVE ENVIRONMENTS THROUGH MULTI-CRITERIA GROUP DECISION-MAKING
Authors: Navarro Martínez Ignacio Javier , MARTI ALBIÑANA JOSE VICENTE , YEPES PIQUERAS VICTOR
Published: August 2023

The construction industry is increasingly recognized as critical in achieving Sustainable Development Goals. Construction activities and infrastructure have both beneficial and non-beneficial impacts, making infrastructure design a focal point of current research investigating how best to contribute to sustainability as society demands. Although methods exist to assess infrastructures' economic, environmental, and social life cycle, the challenge remains in combining these dimensions into a single holistic indicator to facilitate decision-making. This study applies four decision-making techniques (ANP, TOPSIS, COPRAS, and VIKOR) to evaluate five different design alternatives for a concrete bridge exposed to a coastal environment. The results indicate that concretes containing even small amounts of silica fume perform better over their life cycle than other solutions usually considered to increase durability, such as water/cement ratio reduction or concrete cover increase.
Keywords: sustainable design, bridges, life cycle assessment, Analytic Network Process, TOPSIS, VIKOR, COPRAS, Multi-criteria decision-making
Systems thinking: How is it used in project management?
Authors:   UCL, Emes Michael , Griffiths William
Published: August 2023

This study builds on the work used to establish the Systems Thinking SIG as they seek to identify the range of activities classified as systems thinking and how these are seen to add value to projects. The study aims to produce a guide on how to apply systems thinking in projects and to understand whether systems thinking is a critical success factor in complex projects.
How can we hand over projects better?
Authors:   Sheffield Hallam University, Anthony Owen
Published: August 2023

Handing over projects from the project phase to the business as usual environment is often perceived as the end of the job by project practitioners and the start of the job by the end users who will be assuming the management responsibility afterwards. The output of this research is to capture lessons learned and success factors from projects that have completed that transition (some more successfully than others) and share these with the project management community in the hope that it will help more projects to handover successfully.
The wellbeing of project professionals
Authors:   University of Manchester, Cheung Clara , Cattell Keith , Bowen Paul , Davis Jocelyn
Published: August 2023

Although workplace well-being has been regarded as a strong indicator of work performance, very limited research has focused on studying the well-being levels of project professionals (PPs) who are responsible for delivering projects, programmes and portfolios of strategic importance to organisations in all industries (Cui et al., 2016). The better PPs and their teams perform, the better organisations are able to deliver on strategy. To address this knowledge gap, this international collaborative study proposes the following research questions: What are current levels of PPs’ workplace well-being? What factors contribute to PPs’ workplace well-being? What interventions could be introduced to improve PPs’ workplace well-being?
Eliminating modern slavery from projects
Authors:   University of Warwick, Brookes Naomi , Glass Jacqui , Castro Armando , Locatelli Giorgio , Oliomogbe Gloria
Published: August 2023

Modern slavery involves the recruitment, movement, harbouring or receiving of people through any means for the purpose of exploitation. It is an extensive problem and one that causes immense human suffering. International Labour Organization figures suggest that there are 24 million victims of modern slavery or forced labour around the world at any one time, with a substantial proportion of these working on project-related activities. Modern slavery causes reputational risk to organisations from the perspective of customers and investors. In the UK, it is now subject to specific legislation. The damage and costs of legal action and compensation to victims of modern slavery can be crippling. Projects are particularly susceptible to modern slavery as they have complex flows of materials and labour that need to be constantly reinvented for each unique project context.
Sustainability: Inclusive storytelling to aid sustainable development goals
Authors:   Bartlett School of Sustainable Construction, UCL, Sergeeva Natalya
Published: August 2023

The Sustainable Development Goals (SDGs) were established by the United Nations in 2015 as a call to action for individuals, teams, projects, organisations, and industries. The UK is at the forefront of delivering the 2030 agenda for sustainable development (HM Government, 2019). The practice of sustainability involves understanding the ways individuals and teams in projects and organisations respond to the sustainability targets set nationally and internationally. There remains little empirical research exploring the ways in which sustainability is interpreted and practiced by sustainability practitioners, including those whose job title infers direct responsibility (e.g., sustainability consultants, sustainability managers, environmental managers, BREEAM managers, etc.).
Les dérèglements des sens dans les romans fin-de-siècle. L’influence de la musique sur deux personnages névrosés
Authors: Gignoux Anne-Claire
Published: August 2023

Le dérèglement dans À rebours de Huysmans et Madame Gervaisais des frères Goncourt doit être rapproché du sentiment de décadence, prégnant en Europe occidentale à la fin du XIXe siècle. Le duc des Esseintes et Mme Gervaisais subissent les désordres d’un monde disharmonieux, désordres auxquels la musique participe. Sa présence au coeur des romans sous forme d’ekphrasis témoigne à la fois d’une fascination pour cet art parfois jugé supérieur, et d’une compétition entre les arts.
Mettre l’éden aux normes. L’imaginaire territorial de la halte routière québécoise
Authors: Kenniff Thomas-Bernard
Published: August 2023

Cet article propose un voyage à travers l’imaginaire des haltes routières québécoises. Chronotope de l’espace-temps territorial, la halte routière permet d’en saisir les dynamiques contextuelles, aussi bien culturelles, politiques, économiques que symboliques. Dix arrêts sur image d’un périple fait en 2021 couvrant le réseau gouvernemental complet sont présentés. Un imaginaire multiple se compose au fil des images hétérochroniques et hétérotopiques que ces architectures dessinent et fixent au paysage.
Différenciation biotique et perte de plantes de milieux humides dans les tourbières ombrotrophes boisées
Authors: Pellerin Stéphanie , Gratton Camille , Lavoie Martin , Poulin Monique
Published: August 2023

Le boisement est un phénomène de plus en plus observé dans les tourbières ombrotrophes en réponse aux pressions exercées par les activités humaines et le réchauffement climatique. Nous avons évalué les effets de la présence d’un couvert forestier sur la richesse et la diversité floristiques (alpha et bêta) des tourbières ombrotrophes dans 775 parcelles d’inventaires réparties dans 5 domaines ou sous-domaines bioclimatiques au Québec. Nos résultats montrent que la richesse et la diversité floristiques augmentent avec le couvert forestier, principalement dans les tourbières les plus méridionales. Cette hausse est associée à l’installation d’espèces vasculaires d’affinité terrestre et de mousses ayant comme substrats des débris ligneux. En contrepartie, nous observons une baisse d’espèces obligées des milieux humides et des sphaignes. Nous avons aussi montré que plus le couvert forestier des tourbières méridionales était élevé, plus les communautés floristiques étaient distinctes d’un site à l’autre. L’effet est moins important dans les régions plus nordiques probablement en raison d’un ensemble régional d’espèces plus semblable à celui des tourbières. En fonction de ces résultats, nous croyons important de réfléchir à des méthodes pour freiner ou ralentir le processus de boisement afin d’assurer la conservation de la flore particulière des tourbières.
Evaluation and Management of Idiopathic Unilateral Footdrop
Authors: Saygılı Mehmet Selçuk , Tekin Ali Çağrı , Bayraktar Mehmet Kürşad , Kır Mustafa Çağlar , Ayaz Mustafa Buğra , Kanyılmaz Selcen
Published: August 2023

Background: We evaluated patients who were followed after acutely developing single-sided footdrop and improving with conservative management or spontaneously.

Methods: In 2019 and 2020, ten patients were retrospectively evaluated for unilateral weakness of the lower extremity in the form of absent dorsiflexion at the ankle joint and were given a diagnosis of footdrop without etiologic cause. Patients were followed for 18 months. Patients were evaluated for acute footdrop of the affected extremity with electromyography, lumbar spine magnetic resonance imaging (MRI), knee MRI, peripheral MRI neurography, and noncontrast brain MRI. Each patient was evaluated for a history of COVID-19 infection during the past year. Patients with any identified cause were excluded.

Results: Initial evaluation of muscle strength revealed 0/5 by the Medical Research Council muscle testing scale. In two patients, muscle strength was 3/5 at month 6 and in eight patients it was 4/5. Muscle strength of all of the patients improved to 5/5 at 1 year. Six patients were dispensed an ankle-foot orthosis, and nine patients performed physical therapy. Electromyography identified significant neuropathy at the level of the common peroneal at the fibular head in all of the patients. Compared with peroneal nerve stimulation below and above the fibular head in the lateral popliteal fossa, a 50% reduction in sensory amplitude and motor conduction slowing greater than 10 m/sec were present. Knee MRI revealed no masses, edema, or anatomical variations at the level of the fibular head.

Conclusions: Spontaneous resolution of unilateral acute footdrop without an etiologic cause can occur within 1 year.
Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin
Authors: Kong Xiangmudong , Yan Wensheng , Sun Wenqiang , Zhang Yanhong , Yang Hee Jung , Chen Mingyi , Chen Hongwu , de Vere White Ralph W , Zhang Jin , Chen Xinbin
Published: August 2023

TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α−η). ΔNp73 is primarily expressed in neuronal cells and necessary for neuronal development. Interestingly, while TAp73α is a tumor suppressor and predominantly expressed in normal cells, TAp73 is found to be frequently altered in human cancers, suggesting a role of TAp73 C-terminal isoforms in tumorigenesis. To test this, the TCGA SpliceSeq database was searched and showed that exon 11 (E11) exclusion occurs frequently in several human cancers. We also found that p73α to p73γ isoform switch resulting from E11 skipping occurs frequently in human prostate cancers and dog lymphomas. To determine whether p73α to p73γ isoform switch plays a role in tumorigenesis, CRISPR technology was used to generate multiple cancer cell lines and a mouse model in that Trp73 E11 is deleted. Surprisingly, we found that in E11-deificient cells, p73γ becomes the predominant isoform and exerts oncogenic activities by promoting cell proliferation and migration. In line with this, E11-deficient mice were more prone to obesity and B-cell lymphomas, indicating a unique role of p73γ in lipid metabolism and tumorigenesis. Additionally, we found that E11-deficient mice phenocopies Trp73-deficient mice with short lifespan, infertility, and chronic inflammation. Mechanistically, we showed that Leptin, a pleiotropic adipocytokine involved in energy metabolism and oncogenesis, was highly induced by p73γ,necessary for p73γ-mediated oncogenic activity, and associated with p73α to γ isoform switch in human prostate cancer and dog lymphoma. Finally, we showed that E11-knockout promoted, whereas knockdown of p73γ or Leptin suppressed, xenograft growth in mice. Our study indicates that the p73γ-Leptin pathway promotes tumorigenesis and alters lipid metabolism, which may be targeted for cancer management.
Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis
Authors: Maio Mariano , Barros Joaquina , Joly Marine , Vahlas Zoi , Marín Franco José Luis , Genoula Melanie , Monard Sarah C , Vecchione María Belén , Fuentes Federico , Gonzalez Polo Virginia , Quiroga María Florencia , Vermeulen Mónica , Vu Manh Thien-Phong , Argüello Rafael J , Inwentarz Sandra , Musella Rosa , Ciallella Lorena , González Montaner Pablo , Palmero Domingo , Lugo Villarino Geanncarlo , Sasiain María del Carmen , Neyrolles Olivier , Vérollet Christel , Balboa Luciana
Published: August 2023

During tuberculosis (TB), migration of dendritic cells (DCs) from the site of infection to the draining lymph nodes is known to be impaired, hindering the rapid development of protective T-cell-mediated immunity. However, the mechanisms involved in the delayed migration of DCs during TB are still poorly defined. Here, we found that infection of DCs with Mycobacterium tuberculosis (Mtb) triggers HIF1A-mediated aerobic glycolysis in a TLR2-dependent manner, and that this metabolic profile is essential for DC migration. In particular, the lactate dehydrogenase inhibitor oxamate and the HIF1A inhibitor PX-478 abrogated Mtb-induced DC migration in vitro to the lymphoid tissue-specific chemokine CCL21, and in vivo to lymph nodes in mice. Strikingly, we found that although monocytes from TB patients are inherently biased toward glycolysis metabolism, they differentiate into poorly glycolytic and poorly migratory DCs compared with healthy subjects. Taken together, these data suggest that because of their preexisting glycolytic state, circulating monocytes from TB patients are refractory to differentiation into migratory DCs, which may explain the delayed migration of these cells during the disease and opens avenues for host-directed therapies for TB.
Unsupervised discovery of family specific vocal usage in the Mongolian gerbil
Authors: Peterson Ralph E , Choudhri Aman , Mitelut Catalin , Tanelus Aramis , Capo-Battaglia Athena , Williams Alex H , Schneider David M , Sanes Dan H
Published: August 2023

Many animal species use vocalizations to communicate social information and previous experiments in rodents have identified a range of vocal types that may be used for this purpose. However, social vocalizations are typically acquired during brief interactions between animals with no prior social relationship, and under environmental conditions with limited ethological relevance. Here, we establish long-term acoustic recordings from Mongolian gerbil families, a core social group that uses an array of sonic and ultrasonic vocalizations which vary with social context. Three separate gerbil families (two parents and four pups) were transferred to an enlarged environment and continuous 20-day audio recordings were obtained. We leveraged deep-learning based unsupervised analysis of 583,237 vocalizations to show that gerbils exhibit a more complex vocal repertoire than has been previously reported. Furthermore, gerbils displayed family-specific vocal repertoires, including differences in vocal type usage and transitions. Since gerbils live naturally as extended families in complex underground burrows that are adjacent to other families, these results suggest the presence of a vocal dialect which could be exploited by animals to represent kinship.These findings offer insight into the naturalistic vocal tendencies of gerbil families and position the Mongolian gerbil as a compelling animal to study the neural basis of vocal communication.
Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-associated Lymphoid Tissue Lymphoma: A Case Series
Authors: Seo Jun-young , Choi Kee Don , Song In Hye , Park Young Soo , Na Hee Kyong , Ahn Ji Yong , Lee Jeong Hoon , Jung Kee Wook , Kim Do Hoon , Song Ho June , Lee Gin Hyug , Jung Hwoon-Yong
Published: August 2023

Background/Aims: The treatment for gastric mucosa-associated lymphoid tissue lymphoma (MALToma) generally involves eradication of Helicobacter pylori. However, MALToma lesions may recur even without H. pylori re-infection. Furthermore, the remission rate of H. pylori-negative MALToma after eradication is low. Therefore, herein, we report on endoscopic submucosal dissection (ESD) as a treatment strategy for gastric MALToma.Methods: We retrospectively reviewed the data of all patients of gastric MALToma who underwent endoscopic resection at our institution between January 2000 and December 2021. Clinical remission was defined as complete histological remission or probable minimal residual disease according to the GELA grading system for post-treatment evaluation of gastric MALToma.Results: Six patients with gastric MALToma underwent ESD. Two patients were diagnosed with gastric MALToma, which improved after eradication treatment and relapsed approximately 36 and 41 months later, respectively. These patients had singular lesions localized to the mucosa and did not experience H. pylori re-infection. The lesions were successfully removed via ESD. The remaining four patients had H. pylori-negative gastric MALToma. These patients also had single, localized lesions that were removed via ESD. All the patients remained in clinical remission until the final follow-up.Conclusions: ESD is a safe and effective intervention for H. pylori-negative gastric MALToma when the lesion is single and confined to the mucosal layer.
Significaciones sociales del acoso sexual callejero: hegemonía, resistencia y posibilidades para el reconocimiento
Authors:   ,   Pontificia Universidad Católica de Chile. Escuela de Psicología, Arancibia Garrido Javiera Sofía
Published: August 2023

El presente estudio se propuso comprender las significaciones sociales sobre el acoso sexual callejero presentes en 37 noticias publicadas en plataformas Web 2.0 de la prensa digital chilena durante el 2014. Mediante un Análisis Crítico del Discurso, se analizó tanto el discurso de las noticias como el de los comentarios publicados por sus lectores. Además, se realizaron dos grupos de discusión: uno de hombres y otro de mujeres. Esto, con el fin de identificar significaciones sociales sobre el acoso sexual callejero vinculadas a discursos hegemónico y de resistencia; a roles de género y espacio público. Como resultados, el estudio identificó una alta presencia de justificación de la ideología sexista, sobre todo en cuanto a la posición de la mujer como objeto sexual, y en cuanto a la mujer pensada como víctima por sobre sujeto de derechos. Existe, además, una marcada presencia del hombre y de la mujer como figuras homogéneas, superponiéndose considerablemente las categorías de hombre-agresor, y mujer-víctima, donde pareciera que gran parte del debate se explica por una lucha entre los sexos. Las posibilidades de problematización de estas categorías, se ofrecen con la aparición de un discurso de alteridad, en dos niveles. Uno que reconoce el daño que el acoso sexual produce a las mujeres, junto a su conexión con injusticias estructurales, y otro que se desmarca de la necesaria relación entre hombre y agresor, reconociendo que es la cultura patriarcal la causa del problema. Por otra parte, se considera la tesis de que la particularidad del acoso sexual callejero como violencia de género, radica en que se fuerza una relación en la cual el agresor, un desconocido, realiza prácticas con características propias de una relación de intimidad, sin el consentimiento ni el reconocimiento de la víctima como sujeto.
Personality functioning and borderline personality disorder in patients referred for psychiatric consultation in an emergency service
Authors:   ,   Pontificia Universidad Católica de Chile. Escuela de Psicología, Pérez Méndez Ana Jazmín
Published: August 2023

Background: In the last decade, personality disorders suffered a transformation regarding their classification and diagnosis. The personality disorder (PD) dimensional diagnosis proposed by DSM-V´s Alternative Model (AMPD) and CIE-11 defines personality pathology as an impairment in self and interpersonal functioning. In this context, epidemiological data is still scarce, and no studies to date inquire the prevalence of this diagnosis in patients referred for psychiatric consultation in emergency services. Thus, the main objective of this study is to describe the proportion of consultants referred to psychiatric consultation with the AMPD PD diagnosis and the severity of borderline features in this sample. Methods: Participants were adults (+18) consulting an adult general emergency service from a Chilean public hospital in a deprived urban area. We used two self-report screening scales (LPFS-BF 2.0 and ZAN BPD) to measure personality functioning and borderline symptoms. Results: From our total 182 participants sample, 27.5% presented personality functioning impairment. The group with a probable AMPD PD diagnosis consistently scored higher in mean borderline symptomatology. Additionally, the group with personality functioning difficulties presented more psychosocial impairment. Conclusions: Our findings suggest that dimensional PD diagnosis is a highly prevalent condition among patients referred for psychiatric consultation in emergency services. These results underscore the need to gather quality epidemiological data to promote the design and implementation of appropriate emergency care interventions for this condition and to advance PD inclusion in national mental healthcare policies.
Studies on Anti-Fungal Activity of Different Macro Algal Extracts against Soil Borne Pathogen Sclerotium rolfsii Sacc.
Authors: Praveen A. , Kannan C.
Published: August 2023

Management of soil-borne plant pathogens is one of the single greatest challenges facing modern agriculture worldwide. Seaweeds are considered as a source of bioactive compounds as they are able to produce a great variety of secondary metabolites characterized by a broad spectrum of biological activities. The seaweeds derived compounds showing broad range of biological activities such as antiviral, antibacterial and antifungal activities. The antimicrobial activity of macro algal extracts is generally analysed using various organic solvents which always present higher efficiency in extracting bioactive compounds. Among the different the solvent extracted macro algal extracts tested, methanol extracts of Sargassum wightii recorded maximum mycelial inhibition (88.22 %) and on par with aqueous extracts recorded 85.78% of mycelial inhibition @ 10% concentration compared to other macro algal extracts.. Among the fifteen macro algal extracts, maximum inhibition of mycelial growth was recorded the Sargassum wightii (Brown algae), Ulva lactuca (Green algae) and Gracilaria salicornia (red algae) at different concentrations. In this study, we have shown that Sargassum wightii has antimicrobial potential against the S. rolfsii. Methanol extract was found to be the best solvent for retention of the antimicrobial activity
Erroneous Rapid Exchange Balloon Inflation During Coronary Angioplasty in a Male Patient in His 70s With Chronic Stable Angina
Authors: Roul Shishir K. , Arke Avinash , Deshpande Saurabh Ajit
Published: August 2023

This case report discusses an erroneous rapid exchange balloon inflation during coronary angioplasty in a patient who presented with a right coronary artery lesion on angiography.
Foscarnet-Induced Penile Ulceration
Authors: Arnold Justin D. , Smith Janellen
Published: August 2023

This case report describes an uncircumcised male individual with tender perimeatal erythema and ulceration extending to the right glans.