bluuebunny/crossref_metadata_2025 huggingface dataset:
Community People Preparedness and Response on Prevention and Control of COVID-19 Best Practice in Bangladesh
Authors: Das Dr.Bimal Chandra , Bhuiyan Sahedul Islam , Ullah A S M Wali , Alam Muhammad Zahangir , Mostofa Gazi Golam , Hasan Khondaker Zahirul , Sarwar Sohel , Chowdhury Reaz Uddin , Paul Joya , Haque AKM Mahbubul , Islam Mohammad Shamsal , Alauddin Mohammed
Published: November 2020

Purpose: The major objectives of the study were to assess the knowledge, attitude & practice (KAP) towards community preparedness and response on prevention of COVID-19 among the community people.
Method: A sample survey was conducted to collect data from people admitted to a district-level tertiary hospital for the treatment of various health complications during the COVID-19 pandemic. A total of 300 randomly selected patients and their attendants were interviewed in the hospital setting.
Results: The mean knowledge score was 18.73 out of 24 and the main sources of information were TV (86.5%), radio (13%), newspaper (13%), social media (13.5%), friends/relatives (14%), formal healthcare providers (6%) and religious leaders (3%). Knowledge was significantly poor among aged people, women, less educated, and less earning. The majority of the participants (79%) suggested wearing facemasks as effective tools to prevent COVID-19 from spreading, whereas 56% mentioned maintaining physical or social distance as crucial to prevent the infection. We found strong relationship between monthly total family expenses and wearing of facemasks by gender to prevent the COVID-19 (x2= 18.405; Cramer’s V= .17, df = 8; sig; P= < .018). Similarly maintaining physical/social distance to prevent COVID-19 is also related to respondents’ economic strata (x2= 43.741; Cramer’s V= .14, df = 20; Sig; P= < .002).
Conclusions: Awareness program on COVID-19 is very important to prevent the spread of the deadly virus.  Effective communication intervention with increasing treatment facilities is essential for the prevention and control of COVID-19. Government and development agencies should prioritize the COVID-19 response program with regular health care services.
Integrasi Newsroom Media Cetak Jawa Tengah (Studi Pada Harian Suara Merdeka Dan Jawa Pos Radar Semarang Menuju Konvergensi Jurnalistik)
Authors: Permatasari Vincentia Ananda Arum
Published: November 2020

Penikmat informasi media cetak tidak lagi hanya urban native tetapi juga digital native. Untuk itu media cetak harus merubah diri menjadi media informasi yang dapat dijangkau pembacanya. Penelitian ini bertujuan memberi gambaran tentang penerapan model konvergensi media oleh media regional di Kota Semarang. Penelitian ini menggunakan pendekatan kualitatif. Data diperoleh dari wawancara semi-terstruktur terhadap wakil pemimpin redaksi Suara Merdeka dan redaktur pelaksana Jawa Pos Radar Semarang. Hasil penelitian menunjukkan bahwa konvergensi media Suara Merdeka dan Jawa Pos Radar Semarang dilakukan dalam empat area penting, yaitu Lingkup Proyek, Manajemen Ruang Berita, Praktik Jurnalistik, dan Kerja Organisasi. Berdasarkan analisis yang dilakukan, penelitian ini menyimpulkan bahwa SM dan JPRS belum menunjukkan Model Konvergensi Media yang jelas. Walapun kepemilikan media dan infrasruktur produksi telah menerapkan model full integration namun pada praktik jurnalistik dan manajemen ruang berita masih banyak menerapkan cross media  dan co-ordination of isolated platforms.
Construction and validation of the Scale for the Evaluation of the Perception of Counterproductive Behaviors in Organizations (EPCBO)
Authors: Sulea Coralia , Pitariu Horia , Maricuțoiu Laurențiu
Published: November 2020

The purpose of this study was to develop a scale for the perception of counterproductive work behaviors. Employees from four independent samples filled in the questionnaire (total N=390). Two studies were conducted. The first study aimed to item construction and exploratory factor analysis, whereas the second aimed to instrument validation and confirmatory factor analysis. The results confirmed a four factor scale (misuse of information, production deviance, absenteeism and withdrawal, as well as interpersonal counterproductive behavior). The scale has 20 items and can be applied to a wide range of organizations. Implications for managers and future research are also discussed.
Roumanian adaptation of Utrecht Work Engagement Scale: The examination of validity and reliability
Authors: Vîrgă Delia , Zaborilă Cătălina , Sulea Coralia , Maricuțoiu Laurențiu
Published: November 2020

The purpose of this study was to validate the Romanian version of Utrecht Work Engagement Scale (UWES-R). The study was developed in three phases: (1) adaptation for Romanian language of Utrecht Work Engagement Scale (17 item version and 9 item version) (Shaufeli & Bakker, 2003); (2) a comparative analysis of the two scales; (3) a validity analysis for UWES-9 on Romanian population. The factor structure for the two scales was tested using confirmatory factor analysis. The results indicate that the fit indices for UWES-17 are lower than for UWES-9. The comparative analysis of the results indicate that UWES-9 is, generally, more adequate to be used in Romanian organizations. The internal consistency of the UWES-9 scales have values between .70 and .80 and the consistency for the unique factor is almost .90 that suggests a better adequacy for the single factor model. The construct validity analysis shows that work engagement is related to personality dimensions, organizational citizenship and counterproductive work behaviors, organizational justice and job content aspects. The results support the reliability and validity aspects for the tested instrument.
ÜLKELERİN İNOVASYON PERFORMANSININ ÖLÇÜLMESİNDE YAPAY SİNİR AĞLARI, BULANIK DEMATEL TABANLI ANALİTİK AĞ SÜRECİ VE AĞIRLIK KISITLI VERİ ZARFLAMA ANALİZİ YAKLAŞIMLARININ BÜTÜNLEŞİK OLARAK KULLANILMASI VE BİR UYGULAMA
Authors: ÇAKIN Enver , ÖZDEMİR Aslı
Published: November 2020

Bu çalışmada, Yapay Sinir Ağları (YSA), Bulanık DEMATEL Tabanlı Analitik Ağ Süreci (BDAAS) ve Ağırlık Kısıtlı Veri Zarflama Analizi (AKVZA) yaklaşımlarını bütünleşik olarak kullanarak ülkelerin inovasyon performansını ölçen bir model geliştirilmiştir. Küresel İnovasyon Endeksi raporları kapsamında 21 adet inovasyon performans göstergesi ele alınarak öncelikle YSA ile bu kriterler arasındaki ilişkiler belirlenmiştir. Daha sonra bu ilişkiler BDAAS yönteminde kullanılarak kriterlerin önem dereceleri hesaplanmıştır. Son olarak ise bu önem dereceleri ağırlık kısıtı olarak AKVZA yönteminde kullanılarak 104 ülkenin inovasyon performansı ölçülmüştür. Önerilen modelin klasik yöntemlere göre daha gerçekçi çözümler sunduğu ve performansı daha yüksek olan ülkeleri daha iyi ayırt ettiği sonucuna ulaşılmıştır.
Impact of 2008 Global Economic Crisis on Youth Unemployment: An Application to Turkey
Authors: Şahinli Mehmet Arif , Özçelik Ahmet , Güldal Hüseyin Tayyar
Published: November 2020

In recent years, youth unemployment in Turkey is the effect of economic growth on employment and unemployment. When we search studies for employment and unemployment in the literature, we can‘t find many empirical studies for the Turkish economy. In order to contribute about this subject, we try to search the effect of economic growth on youth unemployment for the Turkish economy for the period of 1998-2016 employing Dummy variables. Especially, we found that, increasing effect of economic growth on youth unemployment.
ANÁLISE DOS INDÍCIOS DE CARTEL NAS REVENDEDORAS DE GASOLINA COMUM EM VIÇOSA-MG, 2016 a 2018
Authors: Jacob Kamila Gabriela , Aparecida Soares Fernandes Rosangela , Bornacki de Mattos Leonardo
Published: November 2020

Este artigo teve como objetivo analisar a presença de indícios de conduta colusiva no segmento da gasolina comum na cidade de Viçosa-MG de 2016 a 2018. Para tanto, utilizou-se do Índice Concorrencial de Preços (ICP), das Margens de comercialização na revenda (Mgr) e da Assimetria na Transmissão de Preços (ATP), o que é uma metodologia mais atual na análise de combustíveis no Brasil. Os resultados indicaram indícios de comportamento colusivo em 2016 e 2018, mas se constatou sinais de concorrência em 2017 pelos filtros ICP e Mgr. Por meio da ATP, observou-se a presença de Assimetria do Impacto Contemporâneo (AIC) cujo  choque positivo no preço da gasolina comum é repassado mais rapidamente ao consumidor pelo revendedor, ao invés dos choques negativos. Além disso, a Assimetria na Trajetória de Equilíbrio (ATAE) apontou que a velocidade de convergência depende do preço na revendedora estar abaixo do equilíbrio de longo prazo.
The determinant of brand awareness: Lesson from Indonesia
Authors: Dianty Levita , Magnadi Rizal Hari
Published: November 2020

This study analyzes the effect of advertising creativity, jingles and endorsers on brand awareness using Multiple Linear Regression Analysis on 150 respondents in Semarang. The results showed that advertising creativity, jingles and endorsers have a positive and significant influence on brand awareness. Advertising creativity is the strongest variable affecting brand awareness. Companies need to use this variable as the most important factor because it has positive impacts.
Applying the information acceptance model to predict purchase intention in social media
Authors: Tjongirin Richard , Gianto Matthew , Sihombing Sabrina
Published: November 2020

E-WOM has become an essential marketing tool, as an online marketplace compete to dominate the online space. This paper assesses the relationship of e-WOM and its relationship towards purchase intention. The theoretical model based on the information acceptance model suggesting information (quality, credibility, usefulness, and adoption), needs of information and attitude towards information are the primary variables that influence purchase intention. This is a descriptive research; closed-ended questionnaires were distributed with 294 respondents with college students as the main demographic. The findings of this research show that the usefulness of information does play a significant influence toward purchase intention, but the attitude towards information does not significantly influence information usefulness. This study implies that some companies which compete in the online space should primarily focus on how useful their information is deemed by the consumers.
Loyalty of m-wallet user from a service-dominant logic perspective
Authors: Muna Nalal , Pratiwi Mutia Rahmi , Alkhaliq Barkah
Published: November 2020

This study aimed to examine the effect of customer perceived value on the loyalty of mobile wallet (m-wallet) users. Payment using mobile wallet offers several benefits for consumer in terms of functional, social, and economic value. Meanwhile, Service-Dominant Logic was used to explain consumer’s experience in utilizing mobile wallet for payment. Furthermore, a quantitativeapproach with questionnaire was used for data collection, and a total of 325 users participated as the respondents. A purposivesampling technique was used to determine the sample criteria i.e. active m-wallet users with a minimum usage of 1 year. The result showed that all the hypotheses are supported. This indicated that customer perceived value consist of functional, economic, and social value, which have positive and significant impact on satisfaction that leads to customer loyalty. Meanwhile, satisfactionis the most salient predictor of customer loyalty. Therefore, financial technology provider needs to pay more attention to customer perceived value, especially in terms of functional, economic and social aspect.
Service quality role on customer’s loyalty of Indonesia internet service provider during Covid-19
Authors: Rachmawati Indira
Published: November 2020

The present study developed a conceptual research framework for potential predictors of loyalty to intention and loyalty to the action ofinternet service providers. This study examined whether customer loyalty of Indonesia service provider was related to service quality dimensions (namely network quality, customer service, information quality, security, and privacy) by providing empirical evidence of the relationship among there variables. Customer loyaltywas reflected by the indicators of loyalty to intention, loyalty to action, and willingness to recommend to others. This is to fill the research gap generated by the fact that many previous studies have only studied up to the intention phase and/or have jumped to the action phase without looking at the intention phase.  A quantitative approach through a questionnaire survey was conducted in primary data collection.Out of 400 internet service provider customers surveyed in this study that collected through internet online survey. The findings and results show: Firstly, network quality directly influences attitudinal loyalty. Secondly, customer service directly influences attitudinal loyalty. Thirdly, information quality directly influences attitudinal loyalty. Fourthly, securityand privacynot only directly influence attitudinal loyalty but also influence behavioral loyalty. Finally, attitudinal loyalty directly influences behavioral loyalty. The contribution to academicians interested in the same research topic was the conceptual model. It contributed to the understanding of the cognition-to action loyalty phase framework, also known as the four-stage loyalty phase framework.
On the structure of simple elliptical sentence
Authors: Kamagina Irina Vasilievna
Published: November 2020

This article is dedicated to examination of the component structure of simple elliptical sentence. The author reviews the key theoretical positions pertaining to the structure of these units. A hypothesis is advanced on revelation of the formula of simple elliptical sentence, which consists in idea of three-component nature of these structures with different literal manifestation of the constituent elements of a sentence. The concept of “three-component nature” of elliptical construct suggest the presence of three components, some of which continue to “act while absent”: subject, elliptical verb component, and distributor of verb component. Simple elliptical sentences from the novel by M. A. Sholokhov “And Quiet Flows the Don” served as the material for this research. The following conclusions were made: simple elliptical sentence is a construct with all attributes of a full sentence from the perspective of semantics, as well as structure; their peculiarity consists in elimination of the predicate, which is also one of the structural components of the syntactic under review; structural formula of any elliptical sentence consists in the presence of three components, which can be literary manifested or the other way around. This research contributes to elucidation of the phenomenon of simple elliptical sentences as sentences with more semantic saturation than the construction with verbalized predicate, as well as to more profound research on Sholokhov’s syntax.
Economic and legal aspects of personal bankruptcy
Authors: Piątek Edyta Iwona
Published: November 2020

When a new act on bankruptcy law entered into force on 1 January 2016, it introduced changes in the scope of personal bankruptcy. The article points to the economic aspects of legal solutions provided for in the new regulation for indebted natural persons, significant on a micro and macro scale. At the same time, it points to the problems in the personal bankruptcy procedure which had existed before the amended Act entered into force, and the problems encountered by debtors and courts in connection with these amendments. The article is based on the author's experience in preparing applications for filling for personal bankruptcy and interviews with the judges employed in the bankruptcy and restructuring section of District Courts. The results of conducted observations and interviews were compared to practical cases which are the subject of bankruptcy applications studied as part of the research project
Mongolian genetic component in the gene pool of the indigenous population of Siberia, Central Asia and Eastern Europe
Authors: Хитринская И.Ю. , Харьков В.Н. , Зарубин А.А. , Литвинов С.С. , Екомасова Н.В. , Хуснутдинова Э.К. , Степанов В.А.
Published: November 2020

Выявлен вклад монгольского по происхождению компонента в генофонд различных этносов Сибири, Средней Азии и Волго-Уральского региона, который присутствует у монголоязычных и тюркоязычных этносов. Анализ состава различных сублиний гаплогрупп Y-хромосомы показывает, что привнесение этого генетического компонента было связано с различными по времени миграционными событиями и разными по происхождению родоплеменными группами.

The contribution of the Mongolian component to the gene pool of various ethnic groups of Siberia, Central Asia and the Volga-Ural region, which is present in the Mongol-speaking and Turkic-speaking ethnic groups, is revealed. An analysis of the composition of the various sublines of the Y-chromosome haplogroups shows that the introduction of this genetic component was associated with time-varying migration events and tribal groups of different origin.
The prevalence of type 1 spinocerebellar ataxia in Yakutia: current status
Authors: Фёдоров А.И. , Сухомясова А.Л. , Голикова П.И. , Иванов А.В. , Николаева И.А. , Степанова С.К. , Григорьева Т.П. , Максимова Н.Р.
Published: November 2020

Республика Саха (Якутия) является одним из крупнейших очагов накопления спиноцеребеллярной атаксии 1 типа в мире. В 1997 году показатель распространённости СЦА1 среди якутов составлял 35 случаев на 100000 населения, а в настоящее время данный показатель возрос до 77,6 случаев. Значительный прирост показателей распространённости СЦА1 может быть объяснён внедрением системы учёта семейных случаев и современных молекулярно-генетических методов диагностики мутации. С другой стороны, результаты мониторинга свидетельствуют о продолжающемся накоплении мутации в якутской популяции. Кроме того, установлено расширение границ известных географических очагов накопления мутации и сделано предположение о популяционной неоднородности носителей мутации по числу CAG повторов.

The Republic of Sakha (Yakutia) is one of the largest centers of accumulation of type 1 spinocerebellar ataxia in the world. In 1997, the prevalence of the SCA1 mutation among Yakuts was 35 cases per 100,000 population, and now this indicator has increased to 77.6 cases. A significant increase in the prevalence rates of SCA1 can be explained by the introduction of a family case accounting system and modern molecular genetic methods for the diagnosis of mutations. On the other hand, the monitoring results indicate the ongoing accumulation of mutations in the Yakut population. In addition, it was found that the boundaries of the known geographical centers of mutation accumulation were expanded and an assumption was made about the population heterogeneity of mutation carriers by the number of CAG repeats.
Mutation analysis of the SLC26A4 gene in patients in Yakutia with inner ear abnormalities: IP-I, IP-II (Mondini) and / or EVA
Authors: Кларов Л.А. , Николаева К.Ю. , Никанорова А.А. , Чердонова А.М. , Попов М.М. , Терютин Ф.М. , Пшенникова В.Г. , Лугинов Н.В. , Котляров П.М. , Барашков Н.А.
Published: November 2020

В работе представлены результаты обследований 165 пациентов с врожденными нарушениями слуха из Якутии, проведенных с использованием аудиологических, рентгенологических и молекулярно-генетических методов с целью изучения аутосомно-рецессивной формы глухоты, связанной с аномалиями внутреннего уха (IP-I, IP-II и/или EVA) и мутациями гена SLC26A4 (DFNB4, MIM 600791).

We presents the results of audiological, radiological and molecular genetic studies of 165 patients with congenital hearing impairment in Yakutia to investigate of autosomal recessive form of deafness associated with anomalies of the inner ear (IP-I, IP-II and / or EVA) and mutations in the SLC26A4 gene (DFNB4, MIM 600791).
Complex assessment of the pathogenetic significance of variant с.516G>C (p.Trp172Cys) in the GJB2 gene which is associated with hereditary hearing loss in indigenous population of Southern Siberia
Authors: Маслова Е.А. , Зыцарь М.В. , Данильченко В.Ю. , Орищенко К.Е. , Посух О.Л.
Published: November 2020

В работе приводятся результаты комплексной оценки патогенетической значимости нового варианта с.516G>C (p.Trp172Cys) гена GJB2, выявленного с высокой частотой у больных с потерей слуха из Республик Тыва и Алтай (Южная Сибирь). Совокупность полученных данных свидетельствует в пользу ассоциации этого варианта с наследственной глухотой вследствие его повреждающего эффекта на структуру и функционирование белка коннексина 26 (Cx26).

We present the results of a complex assessment of the pathogenetic significance of novel variant c.516G>C (p.Trp172Cys) of the GJB2 gene found with high frequency in deaf patients from the Tyva and Altai Republics. Several lines of evidences support pathogenicity of this variant due to its damaging effect on the structure and functioning of connexin 26 (Cx26).
QuantStudio 12k flex Real-Time PCR system for screening phenylalanine hydroxylase (PAH) gene mutations
Authors: Курилова О.В. , Климушина М.В. , Киселева А.В. , Скирко О.П. , Сотникова Е.А. , Дивашук М.Г. , Хлебус Э.Ю. , Борисова А.Л. , Долудин Ю.В. , Сломинский П.А. , Мешков А.Н. , Драпкина О.М.
Published: November 2020

Целью работы было создание и апробация панели из 23 мутаций гена PAH, ответственных за развитие фенилкетонурии, и оценка частоты гетерозиготного носительства данных мутаций в популяционной выборке ЭССЕ-Вологда. Исследование включало 642 участника из популяционной выборки региона Вологды. Наличие мутаций в гене PAH определяли с помощью системы QuantStudio 12K Flex Real-Time PCR. Среди 642 участников исследования было выявлено 17 носителей мутаций в гене PAH. Частота гетерозиготных мутаций составила 2,65% (ДИ 95%: 1,55--4,21%) или 1:38 человек. Полученные данные свидетельствуют о высокой частоте носительства мутаций гена PAH в российской популяции. Предложенная панель может быть использована для скрининга носительства мутаций, вызывающих фенилкетонурию.

The aim of the work was to create and test a custom panel of 23 PAH gene variants responsible for the development of phenylketonuria, and to evaluate the frequency of heterozygous carriers of these mutations among 642 participants of the population-based cohort study ESSE-Vologda. The presence of mutations was determined using QuantStudio 12K Flex Real-Time PCR system. 17 carriers of PAH variants among 642 participants were identified. The frequency of heterozygous carriers was 2.65% (CI95%: 1.55-4.21%), or 1:38. The data obtained indicate a high frequency of PAH variants in the Russian population. The proposed panel can be used for screening on heterozygous carriers of variants that cause phenylketonuria.
Results of neonatal screening for hereditary metabolic diseases in the Republic of Kazakhstan for 2019 year
Authors: Святов А.С. , Муртазалиева А.В. , Святова Г.С. , Кирикбаева М.С.
Published: November 2020

Массовое обследование новорождённых в программе неонатального скрининга в Республике Казахстан проводится на 2 наследственных заболевания - фенилкетонурию и врожденный гипотиреоз. В 2019 году был проведен пилотный проект исследований методом тандемной масс-спектрометрии 1000 детей до 1 года на 49 наследственных болезней обмена.

Mass examination of newborns in the neonatal screening program in the Republic of Kazakhstan is carried out for 2 hereditary diseases - phenylketonuria and congenital hypothyroidism. In 2019 pilot project was conducted for 1000 studies using tandem mass spectrometry of children under age of 1 year for 49 hereditary metabolic diseases.
Turkic genetic component in the gene pool of the indigenous population of Dagestan
Authors: Харьков В.Н. , Зарубин А.А. , Хитринская И.Ю. , Раджабов М.О. , Литвинов С.С. , Джаубермезов М.А. , Екомасова Н.В. , Хуснутдинова Э.К. , Степанов В.А.
Published: November 2020

Выявлен вклад тюркского по происхождению компонента в генофонд различных этносов Дагестана и Северного Кавказа, который присутствует не только у тюркоязычных популяций, но и у соседних с ними. В горных популяциях Дагестана, в отличие от равнинных, тюркский компонент практически полностью отсутствует.

The contribution of Turkic genetic component to the gene pool of various ethnic groups of Dagestan and the North Caucasus, which is present not only in Turkic-speaking populations, but also in neighboring ones, is revealed. In the mountain populations of Dagestan, unlike the plains, the Turkic component is almost completely absent.
The role of globotriaosylsphingosine in the diagnosis of Fabry disease in Russian patients
Authors: Мазанова Н.Н. , Пушков А.А. , Пахомов А.В. , Асанов А.Ю. , Савостьянов К.В.
Published: November 2020

Болезнь Фабри (БФ), MIM 301500 - Х-сцепленное заболевание, обусловленное мутациями в гене GLA, который кодирует фермент α-галактозидазу А (α-гал А). В 2017 году в лаборатории молекулярной генетики и медицинской геномики «НМИЦ здоровья детей» Министерства Здравоохранения России был разработан и внедрен метод определения концентрации лизо-Гб3 для диагностики БФ. К настоящему времени нами исследовано 9830 образцов сухих пятен крови из различных регионов России, полученных от 8832 пациентов мужского пола и 998 женского пола, в возрасте от 12 до 70 лет. В результате проведенного исследования у 33 мужчин было выявлено снижение активности фермента, а у 31 из них - повышение концентрации лизо-Гб3, у этих мужчин были обнаружены патогенные варианты гена GLA, тогда как у двух оставшихся мужчин были найдены полиморфные варианты гена GLA, описанные ранее как аллели, обладающие псевдодефицитной активностью. Кроме того, были выявлены 2 женщины с повышенной концентрацией лизо-Гб3, у которых также были обнаружены патогенные варианты гена GLA, тогда как у 5 женщин с псевдодефицитными аллелями гена GLA концентрация лизо-Гб3 была в норме. Наше исследование продемонстрировало преимущество измерения концентрации биомаркера лизо-Гб3 по сравнению с определением активности фермента α-гал А для первичной диагностики мужчин с подозрением на БФ, a также возможность использования этого биомаркера для первичной диагностики женщин с подозрением на БФ.

Fabry Disease (BF), MIM 301500 - X-linked disease caused by mutations in the GLA gene, which encodes the enzyme α-galactosidase A (α-gal A). In 2017, a method for determining the concentration of lyso-Gb3 for the diagnosis of FD was developed and introduced in the laboratory of molecular genetics and medical genomics of the “National Medical Research of Children’s Health Federal State Autonomous Institution of the Ministry of Health of the Russian Federation. To date, we have studied 9830 samples of dry blood spots from various regions of Russia, obtained from 8832 male and 998 female patients, aged 12 to 70 years. As a result of the study, a decrease in enzyme activity was detected in 33 men, and in 31 of them an increase in the concentration of lyso-Gb3, pathogenic variants of the GLA gene were found in these men, while the two remaining men found polymorphic variants of the GLA gene, previously described as alleles with pseudodeficiency activity. In addition, 2 women with an increased concentration of lyso-Gb3 were identified, in whom pathogenic variants of the GLA gene were also detected, while in 5 women with pseudo-deficient alleles of the GLA gene, the concentration of lyso-Gb3 was normal. Our study demonstrated the advantage of measuring the concentration of the lyso-Gb3 biomarker compared to determining the activity of the α-gal A enzyme for the initial diagnosis of men with suspected FD, as well as the possibility of using this biomarker for the initial diagnosis of women with suspected DF.
Manifestation of porphyria by vegetative syncope
Authors: Котов С.В. , Новоженова Ю.В. , Карпова И.В. , Сидорова О.П.
Published: November 2020

Приводится клиническое наблюдение порфирии, при котором симптомы болезни включали вегетативные синкопе.

A clinical observation of porphyria is presented, in which the symptoms of the disease included vegetative syncope.
ATP7B gene study using massively parallel sequencing in patients with Wilson's disease
Authors: Скрябин Н.А. , Васильева О.Ю. , Сивцев А.А. , Жалсанова И.Ж. , Постригань А.Е. , Минайчева Л.И. , Агафонова А.А. , Петрова В.В. , Сивоха В.М. , Филимонова М.Н. , Сеитова Г.Н. , Назаренко Л.П.
Published: November 2020

Болезнь Вильсона-Коновалова (БВК) - аутосомно-рецессивное заболевание, развивающееся вследствие накопления меди в организме при повреждениях гена АТР7В. В настоящем исследовании проводился поиск мутаций в этом гене методом массового параллельного секвенирования у больных с БВК. Для целевого обогащения интересуемых регионов была разработана панель праймеров для ПЦР длинных фрагментов. У 6 пациентов из 12 проанализированных выявлены патогенные и вероятно патогенные варианты нуклеотидной последовательности гена АТР7В. Полученные результаты указывают на то, что разработанный метод таргетного массового параллельного секвенирования позволяет эффективно выявлять мутации в гене ATP7B.

Wilson’s disease is an autosomal recessive disease that develops as a result of the accumulation of copper in the organism when the ATP7B gene is damaged. The present study searched for mutations in this gene using massively parallel sequencing in patients with Wilson’s disease. For targeted enrichment of the regions of interest, a primer panel for PCR of long fragments was developed. In 6 patients out of 12 analyzed, pathogenic and probably pathogenic variants of the nucleotide sequence of the ATP7B gene were identified. The obtained results indicate that the developed method of targeted massively parallel sequencing allows efficient detection of mutations in the ATP7B gene.
Resolving the Equal Number Density Puzzle: Molecular Picture from Simulations of LiCl(aq) and NaCl(aq)
Authors: Nguyen Thi Hong Man , Tichacek Ondrej , Martinez-Seara Hector , Mason Philip E. , Jungwirth Pavel
Published: November 2020

The change in number densities of aqueous solutions of alkali chlorides should be qualitatively predictable. Typically, as cations get bigger the number density of the solution decreases. However, aqueous solutions of lithium and sodium chloride exhibit at ambient conditions practically identical number densities at equal molalities despite different ionic sizes. Here, we provide an atomistic interpretation of this experimentally observed anomalous behavior using molecular dynamics simulations. The obtained results show that rigidity of the Li+ first and second solvation shells and associated compromised hydrogen bonding result in practically equal average water densities in the local hydration regions for Li+ and Na+ despite different sizes of the cations. In addition, in more distant regions from the cations, the water densities of these two solutions also coincide. These findings thus provide an atomistic interpretation for matching number densities of LiCl and NaCl solutions. In contrast, the number density differences between NaCl and KCl solutions, as well as between LiCl and KCl solutions behave in a regular fashion with lower number densities of solutions observed for larger cations.
Covalent and Non-Covalent Binding Free Energy Calculations for Peptidomimetic Inhibitors of SARS-CoV-2 Main Protease
Authors: Awoonor-Williams Ernest , Abu-Saleh Abd Al-Aziz A.
Published: November 2020

COVID-19, the disease caused by the newly discovered coronavirus — SARS-CoV-2, has created global health, social, and economic crisis. At the time of writing (November 12, 2020), there are over 50 million confirmed cases and more than 1 million reported deaths due to COVID-19. Currently, there are no approved vaccines, and recently Veklury (remdesivir) was approved for the treatment of COVID-19 requiring hospitalization. The main protease (Mpro) of the virus is an attractive target for the development of effective antiviral therapeutics because it is required for proteolytic cleavage of viral polyproteins. Furthermore, the Mpro has no human homologues, so drugs designed to bind to this target directly have less risk for off-target reactivity. Recently, several high-resolution crystallographic structures of the Mpro in complex with inhibitors have been determined — to guide drug development and to spur efforts in structure-based drug design. One of the primary objectives of modern structure-based drug design is the accurate prediction of receptor­-ligand binding affinities for rational drug design and discovery. Here, we perform rigorous alchemical absolute binding free energy calculations and QM/MM calculations to give insight into the total binding energy of two recently crystallized inhibitors of SARS-CoV-2 Mpro, namely, N3 and α-ketoamide 13b. The total binding energy consists of both covalent and non-covalent binding components since both compounds are covalent inhibitors of the Mpro. Our results indicate that the covalent and non-covalent binding free energy contributions of both inhibitors to the Mpro target differ significantly. The N3 inhibitor has more favourable non-covalent interactions, particularly hydrogen bonding, in the binding site of the Mpro than the α-ketoamide inhibitor. But the Gibbs energy of reaction for the Mpro–α-ketoamide covalent adduct is greater than the Gibbs reaction energy for the Mpro–N3 covalent adduct. These differences in the covalent and non-covalent binding free energy contributions for both inhibitors could be a plausible explanation for their in vitro differences in antiviral activity. Our findings highlight the importance of both covalent and non-covalent binding free energy contributions to the absolute binding affinity of a covalent inhibitor towards its target.
COVID-19 Knowledge Extractor (COKE): A Tool and a Web Portal to Extract Drug - Target Protein Associations from the CORD-19 Corpus of Scientific Publications on COVID-19
Authors: Korn Daniel , Pervitsky Vera , Bobrowski Tesia , Alves Vinicius , Schmitt Charles , Bizon Cristopher , Baker Nancy , Chirkova Rada , Cherkasov Artem , Muratov Eugene , Tropsha Alexander
Published: November 2020

Objective: The COVID-19 pandemic has catalyzed a widespread effort to identify drug candidates and biological targets of relevance to SARS-COV-2 infection, which resulted in large numbers of publications on this subject. We have built the COVID-19 Knowledge Extractor (COKE), a web application to extract, curate, and annotate essential drug-target relationships from the research literature on COVID-19 to assist drug repurposing efforts. Materials and Methods: SciBiteAI ontological tagging of the COVID Open Research Dataset (CORD-19), a repository of COVID-19 scientific publications, was employed to identify drug-target relationships. Entity identifiers were resolved through lookup routines using UniProt and DrugBank. A custom algorithm was used to identify co-occurrences of protein and drug terms, and confidence scores were calculated for each entity pair. Results: COKE processing of the current CORD-19 database identified about 3,000 drug-protein pairs, including 29 unique proteins and 500 investigational, experimental, and approved drugs. Some of these drugs are presently undergoing clinical trials for COVID-19. Discussion: The rapidly evolving situation concerning the COVID-19 pandemic has resulted in a dramatic growth of publications on this subject in a short period. These circumstances call for methods that can condense the literature into the key concepts and relationships necessary for insights into SARS-CoV-2 drug repurposing. Conclusion: The COKE repository and web application deliver key drug - target protein relationships to researchers studying SARS-CoV-2. COKE portal may provide comprehensive and critical information on studies concerning drug repurposing against COVID-19. COKE is freely available at https://coke.mml.unc.edu/ and the code is available at https://github.com/DnlRKorn/CoKE.
放射性肠炎的中医研究进展
Authors: 臧 刘兵
Published: November 2020

腹部放疗是治疗腹盆腔恶性肿瘤的主要方法之一，在取得临床同时，也可能并发放射性肠炎，引起肠道粘膜组织的严重损伤，甚至最终会继发为肠梗阻，肠穿孔，影响患者正常的消化道功能，降低其生活质量，更甚者危及生命。目前，如何治疗放疗后引起的放射性肠炎，已是临床亟需解决的医学问题，论文针对中医药对放射性肠炎的研究做一综述，争取为临床上防治肿瘤相关病提供新思路、新参考。
放射性肠炎的治疗进展
Authors: 臧 刘兵 , 刘 艳 , 任 孟先 , 张 伟 , 江 后洲
Published: November 2020

放射性肠炎（RE）是放疗后常见的肠道并发症，能累及肠道任何部位。临床主要表现为腹痛、腹泻，肛门灼热，里急后重，严重者可继发为肠梗阻、肠穿孔以及肠瘘等，严重影响患者生活质量。目前，临床上对RE缺乏统一的治疗策略。论文针对RE近5年的治疗进展作一综述，争取为RE的防治提供新思路，新参考。
脑梗塞治疗中奥扎格雷钠联合阿司匹林的应用价值及对NIHSS评分分析
Authors: 李 南生
Published: November 2020

目的：评估脑梗塞患者实施奥扎格雷钠与阿司匹林联合治疗的应用价值及NIHSS评分。方法：针对62例2018年12月-2019年12月期间本医院诊治的脑梗塞患者纳入实验资料，以随机数字表法对患者分成实验组与参照组，每组各31例。分别予行奥扎格雷钠、奥扎格雷钠与阿司匹林联合治疗，对比两组治疗前后相关指标、相关评分、药物不良反应及临床疗效。结果：（1）脑梗塞患者治疗前相关指标具有一致性，显示出数据检验无统计学意义（P＞0.05）。实验组治疗后部分凝血酶原时间长于参照组，与参照组相比，实验组治疗后纤维蛋白原、高敏C反应蛋白较低，显示出数据检验统计学意义（P＜0.05）。（2）脑梗塞患者治疗前相关评分具有一致性，显示出数据检验无统计学意义（P＞0.05）。实验组治疗后NIHSS评分低于参照组，相较参照组，实验组治疗后Batherel指数、生活质量评分较高，显示出数据检验统计学意义（P＜0.05）。（3）脑梗塞患者恶心、腹部不适、食欲不振、呕吐等药物不良反应发生率（12.90%、6.45%）具有一致性，显示出数据检验无统计学意义（P＞0.05）。（4）实验组脑梗塞患者临床疗效（93.55%）高于参照组（70.97%），显示出数据检验统计学意义（P＜0.05）。结论：脑梗塞患者奥扎格雷钠与阿司匹林联合治疗效果确切，可有效调节其生化指标，降低患者临床症状，提升患者自理能力与生活质量，其药物安全性水平较高。
直肠癌新辅助放化疗研究进展
Authors: 张 伟 , 任 孟先 , 赵 友飞 , 刘 艳 , 刘 冬
Published: November 2020

直肠癌是常见的恶性肿瘤疾病，新辅助放化疗已成为直肠癌常用的治疗方案，有利于提高生存率，降低术后复发率。近年来，新辅助放化疗已成为局部晚期中低位直肠癌的标准治疗，论文针对直肠癌新辅助放化疗的现状与研究进展进行综述。
枸杞玛咖胶囊急性毒性和抗疲劳功能实验研究
Authors: 卢 连华
Published: November 2020

目的：研究枸杞玛咖胶囊对实验小鼠的急性毒性作用和缓解体力疲劳作用。方法：选择昆明种健康小鼠，采用急性毒性实验最大耐受量法评价其安全性，采用缓解体力疲劳试验评价其功效作用，为其应用提供理论依据。结果：急性毒性实验动物最大耐受量＞15g/kg.bw，相当于成人临床日用量的300倍；缓解体力疲劳试验与空白对照比较，样品能明显延长小鼠的负重游泳时间、减少小鼠运动时血清尿素生成、增加小鼠肝糖原储备、减少血乳酸曲线下面积。结论：小鼠灌胃成人临床日用量的300倍样品，动物未出现任何毒性反应，表明枸杞玛咖胶囊食用安全；缓解体力疲劳功能试验，与空白对照比较，样品具有显著的缓解体力疲劳功能
超临界色谱-串联质谱法测定以薏苡仁为例的中药材中黄曲霉毒素B1
Authors: 董 琨
Published: November 2020

论文采用超临界色谱-串联质谱法对以薏苡仁为例的中药材中黄曲霉毒素B1进行测定。将样品粉碎后使用70%甲醇溶液进行提取，经免疫亲和柱对AFB1吸附后，用甲醇进行洗脱。以临界CO2-甲醇为流动相梯度洗脱，经Shim-packUC-XRPC18色谱柱(150mm×4.6mm，3μm)分离。采用电喷雾离子源正离子模式，多反应监测(MRM)进行检测。黄曲霉毒素Bl在0.3ng/mL~30ng/mL范围内相关系数分别为0.9999，线性关系良好；平均加标回收率分别为89.7%~100.9%；方法的定量限浓度为0.5μg/kg。本方法简单、安全、准确，可用于检测薏苡仁中黄曲霉毒素的残留量。
胆管癌免疫治疗的研究进展
Authors: 曹 秀洋 , 彭 大旭
Published: November 2020

胆管癌（cholangiocarcinoma）是一种侵袭性恶性肿瘤，发生率较低，但其恶性程度高，且治疗方案有限，预后差，所以需要新的治疗方法。近年来，免疫治疗已成为肿瘤领域的研究热点，它利用患者原有的免疫系统靶向杀伤肿瘤细胞，这种治疗方法在恶性黑色素瘤和晚期非小细胞肺癌中已经取得了令人欣喜的治疗效果。中国和国际上对于胆管癌免疫治疗的新方法也正在进行积极的探索，部分研究在早期实验中也取得了积极的结果。因此，免疫治疗在胆管癌中的应用价值得到了初步证实，值得进一步研究。目前，中国和国际上针对胆管癌的免疫治疗方法主要包括通过肽和树突状细胞疫苗进行靶向肿瘤抗原治疗、同种异体细胞过继免疫治疗以及免疫检测点抑制剂治疗。论文从肿瘤的宿主免疫反应、肿瘤疫苗、过继性T细胞治疗和免疫检测点抑制剂治疗四个方面对其在胆管癌治疗中的研究进展作一综述
血液净化对急性肾功能衰竭的治疗效果及安全性分析
Authors: 张 建磊
Published: November 2020

目的：评析急性肾功能衰竭患者应用血液净化治疗的效果及安全性。方法：选取我院收治的94例急性肾功能衰竭患者进行临床研究，所有患者在分组处理后分别予以间隙性血液净化和连续性血液净化治疗。本研究将通过对两组研究对象的治疗效果、肾功能指标差和并发症发生情况差异进行比较，评析急性肾功能衰竭患者应用血液净化治疗的效果及安全性。结果：两组研究对象治疗期间均未出现严重并发症，组间并发症发生率差异无统计学意义（P＞0.05）；但组间治疗有效率和肾功能指标差异较大，该差异存在统计学意义，P＜0.05。结论：血液净化在急性肾功能衰竭患者治疗中效果显著，不会导致患者出现严重不良反应，具有安全性高的优点。且两组患者治疗后各项肾功能指标均得到明显改善，但连续性血液净化治疗方式的效果更佳，值得推广应用。
医学高等院校基础课程教学模式及成绩评估改革探讨
Authors: 张 宇飞 , 潘 柳林 , 傅 桂莲 , 梁 骥
Published: November 2020

医学高等院校在对医学生培养的过程中，基础医学教育占有五分之四的教学时程。这彰显了要想成为一名合格的医生，必须铺垫深厚的基础知识。考试被用作促进和考核一个学生学习的措施。以往考试的方式是每门课程只在期末进行一次纸质性考试，并以此判定一个学生的“好”与“差”。当前，国家已对医学生的培养提出了新的培养目标要求：医学生不仅要有良好的成绩，更要培养他们的品质、综合分析能力、实践与创新能力。显然，这为我们的基础医学教育模式以及如何实施学生综合素质的评定带来了新的挑战。
PiCCO监测在严重烧伤患者早期治疗的应用进展
Authors: 虎 啸 , 周 军利
Published: November 2020

近年来脉搏轮廓心排血量（PiCCO）监测技术在早期指导严重烧伤患者救治中应用越来越多，并且取得了良好的临床效果，目前已作为治疗严重烧伤患者的一种常规检测方式。论文针对该技术在治疗早期严重烧伤患者近年来的发展进行综述，旨在为临床医生治疗烧伤患者提供参考。
心血管内科常见用药问题及临床合理用药方式研究
Authors: 朱 新征
Published: November 2020

目的：探究心血管内科常见用药问题及临床合理用药方式研究。方法：选取我院收治的72例心血管内科患者，时间区间为2019年10月至2020年10月，采用抛硬币方式随机分为观察组及对照组各36例。观察组通过用药措施展开临床干预，对照组并未实施用药干预。比较分析心理状态、药品管理质量评分、生活质量等情况。结果：观察组的忽视用药禁忌症、重复用药、联合用药不合理、药物剂量过大、药品方法和抗菌药物使用不合理等药品管理质量评分均显著高于对照组，差异有统计学意义（P＜0.05）；观察组的生活质量评分均高于对照组（P＜0.05）；观察组的SAS、SDS的心理状态评分均低于对照组，差异有统计学意义（P＜0.05）。结论：针对心血管内科患者，通过用药措施展开临床干预，能有效改善患者用药问题，通过研究应用整改措施，为患者尽早恢复作出充分保证，同时能一定程度上增强患者的用药指导力度，安全有效，具有临床应用价值。
uso del concepto cáncer como metáfora social. Análisis a través de la prensa escrita (1903-1912)
Authors: Almudéver Campo Laura , Camaño Puig Ramón
Published: November 2020

El objetivo de este artículo es analizar el uso del término cáncer desde una perspectiva social y su representación en la prensa española a comienzos del siglo xx (1903-1912), en los periódicos La Vanguardia y ABC. A partir de la hemeroteca digital de ambos medios se seleccionaron todas y cada una de las veces que se pudo identificar el término «cáncer» y su aplicación metafórica desde una perspectiva de problemática social, procediéndose a la descripción de los rasgos significativos y al análisis del discurso. Encontramos un uso de la palabra cáncer como metáfora social a lo largo del periodo estudiado, siendo común extender la metáfora del cuerpo enfermo a situaciones de orden político o social. El cáncer es una enfermedad con un gran impacto en nuestra sociedad, cuya utilización metafórica es descriptiva y expresa el deseo del cambio, pero su empleo puede comportar la estigmatización de los enfermos afectados por esta patología.
Palabras clave: cáncer, metáfora, sociedad, prensa, España.
 
Abstract
The objective of this article is to analyze the use of the term cancer from a social perspective and its representation in the Spanish press at the beginning of the 20th Century (1903-1912), in the newspapers La Vanguardia and ABC. From the digital mass media library, each and every one of the times that the term «cancer» and its metaphorical application could be identified from a perspective of the social problem was selected, proceeding to the description of the essential features and the discourse analysis. A use of the word cancer as a social metaphor was found throughout the studied period, being common to extend the metaphor of the sick body in situations of political or social order. Cancer is a disease with a great impact on our society, metaphorical use is descriptive and expresses the desire for change, but its use may involve the stigmatization of patients affected by this pathology.
Key words: cancer, metaphor, society, press, Spain.
mirada al Japón de principios del siglo XVII a través de los manuscritos de Rodrigo de Vivero y Sebastián Vizcaíno
Authors: Martínez Roy Adolfo Jesús
Published: November 2020

Durante la presencia española en el sudeste asiático se mantuvieron contactos con otros países de su entorno. Uno de ellos fue Japón. El archipiélago nipón cambió de dirigente tras la batalla de Sekigahara (1600), estableciéndose tras ella una nueva dinastía que dirigiría al país hasta 1868, la familia Tokugawa. En los primeros años de este gobierno las relaciones con los españoles (y con los extranjeros en general) fueron cambiantes, pasando de una situación favorable a terminar rompiéndose. Es en esos primeros años se hallan Rodrigo de Vivero (1564-1636) y Sebastián Vizcaíno (1547/1548-1627). Ambos personajes se entrevistaron tanto con Ieyasu como con Hidetada Tokuwaga. Vivero estuvo en Japón poco antes de que las relaciones entre ambas potencias se rompiesen; por su parte, Vizcaíno las vivió en primera persona. De sus estancias quedaron sus percepciones del país nipón recogidas en dos Relaciones manuscritas. El objetivo que aquí se persigue es analizar y exponer ordenadamente los datos extraídos de sus manuscritos acerca de las costumbres de los japoneses, su arte, su arquitectura, su estructura social, etc. desde el punto de vista de dos personajes que a diferencia de los misioneros no se involucraron en la sociedad japonesa.
Palabras clave: Rodrigo de Vivero, Sebastián Vizcaíno, Japón, Tokugawa, Nueva España, Filipinas.
 
Abstract
During the Spanish presence in Southeaster Asia, contacts were maintained with other neighboring countries. One of them was Japan. The Japanese archipelago changed its leadership after the Battle of Sekigahara (1600), establishing a new dynasty after it that would lead the country until 1868, the Tokugawa family. In the first years of this government relations with the Spanish (and with foreigners in general) were changing, going from a favourable situation to breaking up. It is in those early years that Rodrigo de Vivero (1564-1636) and Sebastián Vizcaíno (1547 / 1548-1627) is found. Both characters interviewed both Ieyasu and Hidetada Tokuwaga. Vivero was in Japan shortly before relations between the two powers were broken; for his part, Vizcaíno lived that in the first person. From his stays remained his perceptions of the Japanese country collected in two manuscript Narrations. The objective pursued here is to analyze and orderly expose the data extracted from his manuscripts about the customs of the Japanese, their art, their architecture, their social structure, etc. from the point of view of two characters who, unlike the missionaries, were not involved in Japanese society.
Key words: Rodrigo de Vivero, Sebastián Vizcaíno, Namban, Iberian century, Japan, Tokugawa, New Spain, Philippines.
Model Pembelajaran PBL Dipadu Strategi NHT Untuk Memotivasi dan Meningkatkan Hasil Belajar Peserta Didik
Authors: Hardianti Hardianti , Copriady Jimmi , Haryati Sri
Published: November 2020

This study aims to increase learning motivation and results student learning through the application of the PBL learning model combined with the NHT strategy on the subject of stoichiometry at MAN 1 Pekanbaru. The population in this study is all students of class X MIA, amounting to four classes. Normality test use Liliefors test which aims to see whether the data used have a normal distribution and homogeneity test using the variance similarity test and test average similarity which aims to see whether the sample used is already homogeneous. Sampling is done by the cluster random sampling method obtained by two classes namely class X MIA 1 as a control class and class X MIA 4 as an experimental class. The results of testing the hypothesis using the t-test showed that there are significant differences between the control class and the experimental class on learning motivation and learning outcomes. Where is learning motivation and results learning experimental class students higher than students in the class control. Determination of the relationship of learning motivation to student learning outcomes done with a person correlation test that shows the existence of a relationship between learning motivation towards learning outcomes of students in the class applied PBL learning models combined NHT strategies on the subject of stoichiometry at MAN 1 Pekanbaru with a strong positive correlation category.
Analisis Pengaruh Pembelajaran Discovery terhadap Minat dan Hasil Belajar Asam Basa Peserta Didik
Authors: Sugiarti Sugiarti , Herawati Netti , Risdawati Risdawati
Published: November 2020

This research is a quasi-experimental that aimed to find out the effect of discovery learning model toward interests and learning outcomes of students in class XI MIA SMAN 3 Pinrang. Independent variable in the research is discovery learning model and direct instruction and dependent variables is areinterest and learning outcomes of acid-base. The population in this research is all students class XI MIA SMAN 3 Pinrang that consist of six classes. Class XI MIA5 as an experiment group that consist of 31 students and class XI MIA2 as a control group that consist of 33 students. The result data of the research was obtained by interest questionnaires and learning outcomes test on acid-base topic for post test. Data were analysed using descriptive statistics and inferential statistics. The results of hypothesis testing for interest using t-test values obtained at tcount = 3,025 and significance level α = 0,05 with df = 3 and ttable = 1,66 because tcount > ttable  it indscate that H0 failed. So the are is effect learning model effect learning model to learning interets of students class XI  MIA SMAN 3 Pinrang. While for testing the learning outcomes using Mann-Whitney test obtained at Zcount  = 3,48 and significance level α = 0,05 with df = 3 and ztable= 1,64. It shows that there is the effect of discovery learning model toward learning outcomes of students in class XI MIA SMAN 3 Pinrang. Testing correlation for experiment group is obtained rcount  = 0,618 on significance level  α = 0,05 and rtable = 0,355, so it can be concluded that there is positive correlation interests with learning outcomes in discovery learning model. While testing correlation for control group is obtained rcount = 0,488 on significance level α = 0,05 and rtable = 0,344, so it can be concluded that there is positive correlation interests and learning outcomes in direct instruction.