bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S4 from Epigenetic Silencing of Novel Tumor Suppressors in Malignant Melanoma
Authors: Muthusamy Viswanathan , Duraisamy Sekhar , Bradbury C. Matthew , Hobbs Cara , Curley David P. , Nelson Betsy , Bosenberg Marcus
Published: March 2023

Supplementary Figure S4 from Epigenetic Silencing of Novel Tumor Suppressors in Malignant Melanoma
Supplementary Figure 2 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Authors: Heltweg Birgit , Gatbonton Tonibelle , Schuler Aaron D. , Posakony Jeff , Li Hongzhe , Goehle Sondra , Kollipara Ramya , DePinho Ronald A. , Gu Yansong , Simon Julian A. , Bedalov Antonio
Published: March 2023

Supplementary Figure 2 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Supplementary Video 1a from Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia
Authors: Franco Marcela , Man Shan , Chen Limor , Emmenegger Urban , Shaked Yuval , Cheung Alison M. , Brown Allison S. , Hicklin Daniel J. , Foster F. Stuart , Kerbel Robert S.
Published: March 2023

Representative cine-loop obtained using ultrasound biomicroscopic (UBM) imaging (as explained in Materials and Methods) corresponding to MDA-MB-231 tumor xenograft treated with DC101 for a 3-week period.
Supplementary Figure 4 from Activation of Insulin-like Growth Factor Signaling Induces Apoptotic Cell Death Under Prolonged Hypoxia by Enhancing Endoplasmic Reticulum Stress Response
Authors: Endo Hiroko , Murata Kohei , Mukai Mutsuko , Ishikawa Osamu , Inoue Masahiro
Published: March 2023

Supplementary Figure 4 from Activation of Insulin-like Growth Factor Signaling Induces Apoptotic Cell Death Under Prolonged Hypoxia by Enhancing Endoplasmic Reticulum Stress Response
Supplementary Figure Legend from The Asn418-Linked N-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
Authors: Yokoe Shunichi , Takahashi Motoko , Asahi Michio , Lee Seung Ho , Li Wei , Osumi Daisuke , Miyoshi Eiji , Taniguchi Naoyuki
Published: March 2023

Supplementary Figure Legend from The Asn418-Linked N-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
Supplementary Figures 1 and 2 from Bone Morphogenetic Protein 7 Protects Prostate Cancer Cells from Stress-Induced Apoptosis via Both Smad and c-Jun NH2-Terminal Kinase Pathways
Authors: Yang Shangxin , Lim Minyoung , Pham Linda K. , Kendall Stephen E. , Reddi A. Hari , Altieri Dario C. , Roy-Burman Pradip
Published: March 2023

Supplementary Figures 1 and 2 from Bone Morphogenetic Protein 7 Protects Prostate Cancer Cells from Stress-Induced Apoptosis via Both Smad and c-Jun NH2-Terminal Kinase Pathways
Supplementary Figure 1C from Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-Cell Acute Lymphoblastic Leukemia by Remote 3′-BCL11B Enhancers and Coregulation by PU.1 and HMGA1
Authors: Nagel Stefan , Scherr Michaela , Kel Alexander , Hornischer Klaus , Crawford Gregory E. , Kaufmann Maren , Meyer Corinna , Drexler Hans G. , MacLeod Roderick A.F.
Published: March 2023

Supplementary Figure 1C from Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-Cell Acute Lymphoblastic Leukemia by Remote 3′-BCL11B Enhancers and Coregulation by PU.1 and HMGA1
Supplementary Figure 1 Legend from Inhibition of Epidermal Growth Factor Receptor Signaling Elevates 15-Hydroxyprostaglandin Dehydrogenase in Non–Small-Cell Lung Cancer
Authors: Yang Li , Amann Joseph M. , Kikuchi Takefumi , Porta Rut , Guix Marta , Gonzalez Adriana , Park Kyung-Ho , Billheimer Dean , Arteaga Carlos L. , Tai Hsin-Hsiung , DuBois Raymond , Carbone David P. , Johnson David H.
Published: March 2023

Supplementary Figure 1 Legend from Inhibition of Epidermal Growth Factor Receptor Signaling Elevates 15-Hydroxyprostaglandin Dehydrogenase in Non–Small-Cell Lung Cancer
Supplementary Figure 3 from Molecular Mechanisms of RET Receptor–Mediated Oncogenesis in Multiple Endocrine Neoplasia 2B
Authors: Gujral Taranjit S. , Singh Vinay K. , Jia Zongchao , Mulligan Lois M.
Published: March 2023

Supplementary Figure 3 from Molecular Mechanisms of RET Receptor–Mediated Oncogenesis in Multiple Endocrine Neoplasia 2B
Supplementary Figure 2 from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization
Authors: Giglio Simona , Mancini Francesca , Gentiletti Francesca , Sparaco Giorgia , Felicioni Lara , Barassi Fabio , Martella Carla , Prodosmo Andrea , Iacovelli Stefano , Buttitta Fiamma , Farsetti Antonella , Soddu Silvia , Marchetti Antonio , Sacchi Ada , Pontecorvi Alfredo , Moretti Fabiola
Published: March 2023

Supplementary Figure 2 from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization
Supplementary Figure 4 from Dormant Tumor Cells Develop Cross-Resistance to Apoptosis Induced by CTLs or Imatinib Mesylate via Methylation of Suppressor of Cytokine Signaling 1
Authors: Saudemont Aurore , Hamrouni Abdelbasset , Marchetti Philippe , Liu Jizhong , Jouy Nathalie , Hetuin Dominique , Colucci Francesco , Quesnel Bruno
Published: March 2023

Supplementary Figure 4 from Dormant Tumor Cells Develop Cross-Resistance to Apoptosis Induced by CTLs or Imatinib Mesylate via Methylation of Suppressor of Cytokine Signaling 1
Supplementary Figure 6 from Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor-κB via c-SRC– and Oxidant-Dependent Cell Death
Authors: Lluis Josep M. , Buricchi Francesca , Chiarugi Paola , Morales Albert , Fernandez-Checa José C.
Published: March 2023

Supplementary Figure 6 from Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor-κB via c-SRC– and Oxidant-Dependent Cell Death
Supplementary Table 10 from Eukaryotic Translation Initiation Factor 4E–Induced Progression of Primary Human Mammary Epithelial Cells along the Cancer Pathway Is Associated with Targeted Translational Deregulation of Oncogenic Drivers and Inhibitors
Authors: Larsson Ola , Li Shunan , Issaenko Olga A. , Avdulov Svetlana , Peterson Mark , Smith Karen , Bitterman Peter B. , Polunovsky Vitaly A.
Published: March 2023

Supplementary Table 10 from Eukaryotic Translation Initiation Factor 4E–Induced Progression of Primary Human Mammary Epithelial Cells along the Cancer Pathway Is Associated with Targeted Translational Deregulation of Oncogenic Drivers and Inhibitors
Supplementary Table 4 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?
Authors: Rassool Feyruz V. , Gaymes Terry J. , Omidvar Nader , Brady Nicola , Beurlet Stephanie , Pla Marika , Reboul Murielle , Lea Nicholas , Chomienne Christine , Thomas Nicholas S.B. , Mufti Ghulam J. , Padua Rose Ann
Published: March 2023

Supplementary Table 4 from Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?
Supplementary Table 1 from Melanocyte Expression of Survivin Promotes Development and Metastasis of UV-Induced Melanoma in HGF-Transgenic Mice
Authors: Thomas Joshua , Liu Tong , Cotter Murray A. , Florell Scott R. , Robinette Kyle , Hanks Adrianne N. , Grossman Douglas
Published: March 2023

Supplementary Table 1 from Melanocyte Expression of Survivin Promotes Development and Metastasis of UV-Induced Melanoma in HGF-Transgenic Mice
Supplementary Figure 2 from Krüppel-Like Factor 8 Induces Epithelial to Mesenchymal Transition and Epithelial Cell Invasion
Authors: Wang Xianhui , Zheng Mingzhe , Liu Gang , Xia Weiya , McKeown-Longo Paula J. , Hung Mien-Chie , Zhao Jihe
Published: March 2023

Supplementary Figure 2 from Krüppel-Like Factor 8 Induces Epithelial to Mesenchymal Transition and Epithelial Cell Invasion
Supplementary Figures 1-2 from Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
Authors: Raynaud Florence I. , Eccles Suzanne , Clarke Paul A. , Hayes Angela , Nutley Bernard , Alix Sonia , Henley Alan , Di-Stefano Francesca , Ahmad Zahida , Guillard Sandrine , Bjerke Lynn M. , Kelland Lloyd , Valenti Melanie , Patterson Lisa , Gowan Sharon , de Haven Brandon Alexis , Hayakawa Masahiko , Kaizawa Hiroyuki , Koizumi Tomonubu , Ohishi Takahide , Patel Sonal , Saghir Nahid , Parker Peter , Waterfield Mike , Workman Paul
Published: March 2023

Supplementary Figures 1-2 from Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
Supplementary Figure 3 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer
Authors: Paulson K. Eric , Rieger-Christ Kimberly , McDevitt Michael A. , Kuperwasser Charlotte , Kim Jiyoung , Unanue Vincent E. , Zhang Xiaowei , Hu Maowen , Ruthazer Robin , Berasi Stephen P. , Huang Chun-Yin , Giri Dilip , Kaufman Seth , Dugan John M. , Blum Joanne , Netto Georges , Wazer David E. , Summerhayes Ian C. , Yee Amy S.
Published: March 2023

Supplementary Figure 3 from Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer
Supplementary Table 1 from Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells
Authors: Ho Maria M. , Ng Alvin V. , Lam Stephen , Hung Jaclyn Y.
Published: March 2023

Supplementary Table 1 from Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells
Supplementary Figure 2 from Lupeol Suppresses Cisplatin-Induced Nuclear Factor-κB Activation in Head and Neck Squamous Cell Carcinoma and Inhibits Local Invasion and Nodal Metastasis in an Orthotopic Nude Mouse Model
Authors: Lee Terence K. , Poon Ronnie T.P. , Wo Jana Y. , Ma Stephanie , Guan Xin-Yuan , Myers Jeffrey N. , Altevogt Peter , Yuen Anthony P.W.
Published: March 2023

Supplementary Figure 2 from Lupeol Suppresses Cisplatin-Induced Nuclear Factor-κB Activation in Head and Neck Squamous Cell Carcinoma and Inhibits Local Invasion and Nodal Metastasis in an Orthotopic Nude Mouse Model
Supplementary Figure 1 from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Authors: Pogacic Vanda , Bullock Alex N. , Fedorov Oleg , Filippakopoulos Panagis , Gasser Christelle , Biondi Andrea , Meyer-Monard Sandrine , Knapp Stefan , Schwaller Juerg
Published: March 2023

Supplementary Figure 1 from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Supplementary Figure 5 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Authors: Rebacz Blanka , Larsen Thomas O. , Clausen Mads H. , Rønnest Mads H. , Löffler Harald , Ho Anthony D. , Krämer Alwin
Published: March 2023

Supplementary Figure 5 from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Supplementary Table 1 from Gene Expression Profiling of Childhood Adrenocortical Tumors
Authors: West Alina Nico , Neale Geoffrey A. , Pounds Stanley , Figueredo Bonald C. , Rodriguez Galindo Carlos , Pianovski Mara Albonei D. , Oliveira Filho Antonio G. , Malkin David , Lalli Enzo , Ribeiro Raul , Zambetti Gerard P.
Published: March 2023

Supplementary Table 1 from Gene Expression Profiling of Childhood Adrenocortical Tumors
Supplementary Figure 1 from EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins
Authors: Potikyan Gary , Savene Rupert O.V. , Gaulden Julie M. , France Kelly A. , Zhou Zhichao , Kleinerman Eugenie S. , Lessnick Stephen L. , Denny Christopher T.
Published: March 2023

Supplementary Figure 1 from EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins
Supplementary Legends 1-2 from Antiapoptotic Effects of Progastrin on Pancreatic Cancer Cells Are Mediated by Sustained Activation of Nuclear Factor-κB
Authors: Rengifo-Cam William , Umar Shahid , Sarkar Shubhashish , Singh Pomila
Published: March 2023

Supplementary Legends 1-2 from Antiapoptotic Effects of Progastrin on Pancreatic Cancer Cells Are Mediated by Sustained Activation of Nuclear Factor-κB
Supplementary Table 4 from Effects of Phenylethyl Isothiocyanate on Early Molecular Events in N-Nitrosomethylbenzylamine–Induced Cytotoxicity in Rat Esophagus
Authors: Reen Rashmeet K. , Dombkowski Alan A. , Kresty Laura A. , Cukovic Daniela , Mele Jennifer M. , Salagrama Sridevi , Nines Ronald , Stoner Gary D.
Published: March 2023

Supplementary Table 4 from Effects of Phenylethyl Isothiocyanate on Early Molecular Events in N-Nitrosomethylbenzylamine–Induced Cytotoxicity in Rat Esophagus
Supplementary Figure 4 from p53-Mediated Growth Suppression in Response to Nutlin-3 in Cyclin D1–Transformed Cells Occurs Independently of p21
Authors: Kan Charlene E. , Patton John T. , Stark George R. , Jackson Mark W.
Published: March 2023

Supplementary Figure 4 from p53-Mediated Growth Suppression in Response to Nutlin-3 in Cyclin D1–Transformed Cells Occurs Independently of p21
Supplementary Figure 2 from Mapping Genes that Contribute to Daunorubicin-Induced Cytotoxicity
Authors: Duan Shiwei , Bleibel Wasim K. , Huang Rong Stephanie , Shukla Sunita J. , Wu Xiaolin , Badner Judith A. , Dolan M. Eileen
Published: March 2023

Supplementary Figure 2 from Mapping Genes that Contribute to Daunorubicin-Induced Cytotoxicity
Supplementary Figure Legends 1-2 from Tumor Suppressor Activity of CCAAT/Enhancer Binding Protein α Is Epigenetically Down-regulated in Head and Neck Squamous Cell Carcinoma
Authors: Bennett Kristi L. , Hackanson Björn , Smith Laura T. , Morrison Carl D. , Lang James C. , Schuller David E. , Weber Frank , Eng Charis , Plass Christoph
Published: March 2023

Supplementary Figure Legends 1-2 from Tumor Suppressor Activity of CCAAT/Enhancer Binding Protein α Is Epigenetically Down-regulated in Head and Neck Squamous Cell Carcinoma
Supplementary Figure 1 from Lipid Raft–Specific Knockdown of Src Family Kinase Activity Inhibits Cell Adhesion and Cell Cycle Progression of Breast Cancer Cells
Authors: Hitosugi Taro , Sato Moritoshi , Sasaki Kazuki , Umezawa Yoshio
Published: March 2023

Supplementary Figure 1 from Lipid Raft–Specific Knockdown of Src Family Kinase Activity Inhibits Cell Adhesion and Cell Cycle Progression of Breast Cancer Cells
Supplementary Figure Legends 1-6 from Eradication of Large Tumors in Mice by a Tritherapy Targeting the Innate, Adaptive, and Regulatory Components of the Immune System
Authors: Berraondo Pedro , Nouzé Clémence , Préville Xavier , Ladant Daniel , Leclerc Claude
Published: March 2023

Supplementary Figure Legends 1-6 from Eradication of Large Tumors in Mice by a Tritherapy Targeting the Innate, Adaptive, and Regulatory Components of the Immune System
Supplementary Data 1 from Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells
Authors: Hellebrekers Debby M.E.I. , Melotte Veerle , Viré Emmanuelle , Langenkamp Elise , Molema Grietje , Fuks François , Herman James G. , Van Criekinge Wim , Griffioen Arjan W. , van Engeland Manon
Published: March 2023

Supplementary Data 1 from Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells
Supplementary Table 1 from Proton Pump Inhibitors Induce Apoptosis of Human B-Cell Tumors through a Caspase-Independent Mechanism Involving Reactive Oxygen Species
Authors: De Milito Angelo , Iessi Elisabetta , Logozzi Mariantonia , Lozupone Francesco , Spada Massimo , Marino Maria Lucia , Federici Cristina , Perdicchio Maurizio , Matarrese Paola , Lugini Luana , Nilsson Anna , Fais Stefano
Published: March 2023

Supplementary Table 1 from Proton Pump Inhibitors Induce Apoptosis of Human B-Cell Tumors through a Caspase-Independent Mechanism Involving Reactive Oxygen Species
Supplementary Figure 1 from Host Perforin Reduces Tumor Number but Does Not Increase Survival in Oncogene-Driven Mammary Adenocarcinoma
Authors: Street Shayna E.A. , Zerafa Nadeen , Iezzi Manuela , Westwood Jennifer A. , Stagg John , Musiani Piero , Smyth Mark J.
Published: March 2023

Supplementary Figure 1 from Host Perforin Reduces Tumor Number but Does Not Increase Survival in Oncogene-Driven Mammary Adenocarcinoma
Supplementary Figure 1 from Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Authors: Maloney Alison , Clarke Paul A. , Naaby-Hansen Soren , Stein Rob , Koopman Jens-Oliver , Akpan Akunna , Yang Alice , Zvelebil Marketa , Cramer Rainer , Stimson Lindsay , Aherne Wynne , Banerji Udai , Judson Ian , Sharp Swee , Powers Marissa , deBilly Emmanuel , Salmons Joanne , Walton Michael , Burlingame Al , Waterfield Michael , Workman Paul
Published: March 2023

Supplementary Figure 1 from Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Supplementary Figures 1-7 from Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound d-1-Methyl-Tryptophan
Authors: Metz Richard , DuHadaway James B. , Kamasani Uma , Laury-Kleintop Lisa , Muller Alexander J. , Prendergast George C.
Published: March 2023

Supplementary Figures 1-7 from Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound d-1-Methyl-Tryptophan
Supplementary Figure 4 from Differential Regulation of Hypoxia-Induced CXCR4 Triggering during B-Cell Development and Lymphomagenesis
Authors: Piovan Erich , Tosello Valeria , Indraccolo Stefano , Masiero Massimo , Persano Luca , Esposito Giovanni , Zamarchi Rita , Ponzoni Maurilio , Chieco-Bianchi Luigi , Dalla-Favera Riccardo , Amadori Alberto
Published: March 2023

Supplementary Figure 4 from Differential Regulation of Hypoxia-Induced CXCR4 Triggering during B-Cell Development and Lymphomagenesis
Supplementary Figure 1 from Estrogen Insensitivity in a Model of Estrogen Receptor–Positive Breast Cancer Lymph Node Metastasis
Authors: Harrell Joshua Chuck , Dye Wendy W. , Harvell Djuana M.E. , Pinto Mauricio , Jedlicka Paul , Sartorius Carol A. , Horwitz Kathryn B.
Published: March 2023

Supplementary Figure 1 from Estrogen Insensitivity in a Model of Estrogen Receptor–Positive Breast Cancer Lymph Node Metastasis
Supplementary Legends 1-2 from Activation of Toll-like Receptor 4 on Tumor Cells In vitro Inhibits Subsequent Tumor Growth In vivo
Authors: Andreani Virginia , Gatti Gerardo , Simonella Lucio , Rivero Virginia , Maccioni Mariana
Published: March 2023

Supplementary Legends 1-2 from Activation of Toll-like Receptor 4 on Tumor Cells In vitro Inhibits Subsequent Tumor Growth In vivo
Supplementary Figure A6-1 from High Expression of Lymphocyte-Associated Genes in Node-Negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates
Authors: Alexe Gabriela , Dalgin Gul S. , Scanfeld Daniel , Tamayo Pablo , Mesirov Jill P. , DeLisi Charles , Harris Lyndsay , Barnard Nicola , Martel Maritza , Levine Arnold J. , Ganesan Shridar , Bhanot Gyan
Published: March 2023

Supplementary Figure A6-1 from High Expression of Lymphocyte-Associated Genes in Node-Negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates
Supplementary Figures 1-5 from A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity
Authors: Garlich Joseph R. , De Pradip , Dey Nandini , Su Jing Dong , Peng Xiaodong , Miller Antoinette , Murali Ravoori , Lu Yiling , Mills Gordon B. , Kundra Vikas , Shu H-K. , Peng Qiong , Durden Donald L.
Published: March 2023

Supplementary Figures 1-5 from A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity
Supplementary Figure 5 from Hsp27 Modulates p53 Signaling and Suppresses Cellular Senescence
Authors: O'Callaghan-Sunol Cornelia , Gabai Vladimir L. , Sherman Michael Y.
Published: March 2023

Supplementary Figure 5 from Hsp27 Modulates p53 Signaling and Suppresses Cellular Senescence
Supplementary Figure 3 from Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells
Authors: Hussain Azhar R. , Al-Jomah Naif A. , Siraj Abdul K. , Manogaran Pulicat , Al-Hussein Khalid , Abubaker Jehad , Platanias Leonidas C. , Al-Kuraya Khawla S. , Uddin Shahab
Published: March 2023

Supplementary Figure 3 from Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells
Supplementary Figure Legends 1-4 from Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells
Authors: Westbrook Louise , Manuvakhova Marina , Kern Francis G. , Estes Norman R. , Ramanathan Harish N. , Thottassery Jaideep V.
Published: March 2023

Supplementary Figure Legends 1-4 from Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells
Supplementary Figure 2 from Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells
Authors: Westbrook Louise , Manuvakhova Marina , Kern Francis G. , Estes Norman R. , Ramanathan Harish N. , Thottassery Jaideep V.
Published: March 2023

Supplementary Figure 2 from Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells
Supplementary Figure 1 from Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells
Authors: Westbrook Louise , Manuvakhova Marina , Kern Francis G. , Estes Norman R. , Ramanathan Harish N. , Thottassery Jaideep V.
Published: March 2023

Supplementary Figure 1 from Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells
Supplementary Figure 5 from Pediatric Malignant Germ Cell Tumors Show Characteristic Transcriptome Profiles
Authors: Palmer Roger D. , Barbosa-Morais Nuno L. , Gooding Emma L. , Muralidhar Balaji , Thornton Claire M. , Pett Mark R. , Roberts Ian , Schneider Dominik T. , Thorne Natalie , Tavaré Simon , Nicholson James C. , Coleman Nicholas
Published: March 2023

Supplementary Figure 5 from Pediatric Malignant Germ Cell Tumors Show Characteristic Transcriptome Profiles
MAIME Checklist from Pediatric Malignant Germ Cell Tumors Show Characteristic Transcriptome Profiles
Authors: Palmer Roger D. , Barbosa-Morais Nuno L. , Gooding Emma L. , Muralidhar Balaji , Thornton Claire M. , Pett Mark R. , Roberts Ian , Schneider Dominik T. , Thorne Natalie , Tavaré Simon , Nicholson James C. , Coleman Nicholas
Published: March 2023

MAIME Checklist from Pediatric Malignant Germ Cell Tumors Show Characteristic Transcriptome Profiles
Supplementary Figure 1 from CARM1 Regulates Estrogen-Stimulated Breast Cancer Growth through Up-regulation of E2F1
Authors: Frietze Seth , Lupien Mathieu , Silver Pamela A. , Brown Myles
Published: March 2023

Supplementary Figure 1 from CARM1 Regulates Estrogen-Stimulated Breast Cancer Growth through Up-regulation of E2F1
Supplementary Figures S1-S9 from Combined Lysophosphatidic Acid/Platelet-Derived Growth Factor Signaling Triggers Glioma Cell Migration in a Tenascin-C Microenvironment
Authors: Lange Katrin , Kammerer Martial , Saupe Falk , Hegi Monika E. , Grotegut Stefan , Fluri Erika , Orend Gertraud
Published: March 2023

Supplementary Figures S1-S9 from Combined Lysophosphatidic Acid/Platelet-Derived Growth Factor Signaling Triggers Glioma Cell Migration in a Tenascin-C Microenvironment
Supplementary Table 1 from Improvement of Antitumor Activity by Gene Amplification with a Replicating but Nondisseminating Adenovirus
Authors: Bourbeau Denis , Lau Cara Jean , Jaime Jairo , Koty Zafiro , Zehntner Simone P. , Lavoie Geneviève , Mes-Masson Anne-Marie , Nalbantoglu Josephine , Massie Bernard
Published: March 2023

Supplementary Table 1 from Improvement of Antitumor Activity by Gene Amplification with a Replicating but Nondisseminating Adenovirus
Supplementary Methods and Tables 1-4 from Genetic Variation at the CYP19A1 Locus Predicts Circulating Estrogen Levels but not Breast Cancer Risk in Postmenopausal Women
Authors: Haiman Christopher A. , Dossus Laure , Setiawan V. Wendy , Stram Daniel O. , Dunning Alison M. , Thomas Gilles , Thun Michael J. , Albanes Demetrius , Altshuler David , Ardanaz Eva , Boeing Heiner , Buring Julie , Burtt Noël , Calle Eugenia E. , Chanock Stephen , Clavel-Chapelon Françoise , Colditz Graham A. , Cox David G. , Feigelson Heather Spencer , Hankinson Susan E. , Hayes Richard B. , Henderson Brian E. , Hirschhorn Joel N. , Hoover Robert , Hunter David J. , Kaaks Rudolf , Kolonel Laurence N. , Le Marchand Loïc , Lenner Per , Lund Eiliv , Panico Salvatore , Peeters Petra H. , Pike Malcolm C. , Riboli Elio , Tjonneland Anne , Travis Ruth , Trichopoulos Dimitrios , Wacholder Sholom , Ziegler Regina G.
Published: March 2023

Supplementary Methods and Tables 1-4 from Genetic Variation at the CYP19A1 Locus Predicts Circulating Estrogen Levels but not Breast Cancer Risk in Postmenopausal Women
Supplementary Figure 1 Legend from Immunoediting Sculpts Tumor Epitopes during Immunotherapy
Authors: Singh Reshma , Paterson Yvonne
Published: March 2023

Supplementary Figure 1 Legend from Immunoediting Sculpts Tumor Epitopes during Immunotherapy
Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
Authors: Liontos Michalis , Koutsami Marilena , Sideridou Maria , Evangelou Konstantinos , Kletsas Dimitris , Levy Brynn , Kotsinas Athanassios , Nahum Odelia , Zoumpourlis Vassilis , Kouloukoussa Mirsini , Lygerou Zoi , Taraviras Stavros , Kittas Christos , Bartkova Jirina , Papavassiliou Athanasios G. , Bartek Jiri , Halazonetis Thanos D. , Gorgoulis Vassilis G.
Published: March 2023

Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
Supplementary Figure 4 from Krüppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells
Authors: Wei Daoyan , Kanai Masahsi , Jia Zhiliang , Le Xiangdong , Xie Keping
Published: March 2023

Supplementary Figure 4 from Krüppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells
Supplementary Figure 2 from Hepatocellular Carcinoma Associated with Liver-Gender Disruption in Male Mice
Authors: Rogers Arlin B. , Theve Elizabeth J. , Feng Yan , Fry Rebecca C. , Taghizadeh Koli , Clapp Kristen M. , Boussahmain Chakib , Cormier Kathleen S. , Fox James G.
Published: March 2023

Supplementary Figure 2 from Hepatocellular Carcinoma Associated with Liver-Gender Disruption in Male Mice
Methods, Figures 1-5, Movie Legends 1-2 from Human Cancer Cells Commonly Acquire DNA Damage during Mitotic Arrest
Authors: Dalton W. Brian , Nandan Mandayam O. , Moore Ryan T. , Yang Vincent W.
Published: March 2023

Methods, Figures 1-5, Movie Legends 1-2 from Human Cancer Cells Commonly Acquire DNA Damage during Mitotic Arrest
Supplementary Movie 1 from Inhibitor of Growth 4 Suppresses Cell Spreading and Cell Migration by Interacting with a Novel Binding Partner, Liprin α1
Authors: Shen Jiang-Cheng , Unoki Motoko , Ythier Damien , Duperray Alain , Varticovski Lyuba , Kumamoto Kensuke , Pedeux Remy , Harris Curtis C.
Published: March 2023

Supplementary Movie 1 from Inhibitor of Growth 4 Suppresses Cell Spreading and Cell Migration by Interacting with a Novel Binding Partner, Liprin α1
Supplementary Table 5 from Identification of Tumor-Initiating Cells in a p53-Null Mouse Model of Breast Cancer
Authors: Zhang Mei , Behbod Fariba , Atkinson Rachel L. , Landis Melissa D. , Kittrell Frances , Edwards David , Medina Daniel , Tsimelzon Anna , Hilsenbeck Susan , Green Jeffrey E. , Michalowska Aleksandra M. , Rosen Jeffrey M.
Published: March 2023

Supplementary Table 5 from Identification of Tumor-Initiating Cells in a p53-Null Mouse Model of Breast Cancer
Supplementary Figure 1 from MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1
Authors: Engelmann Katja , Shen Hongmei , Finn Olivera J.
Published: March 2023

Supplementary Figure 1 from MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1
Supplementary Materials and Methods, Figure Legends 1-5 from Androgen Induction of the Androgen Receptor Coactivator Four and a Half LIM Domain Protein-2: Evidence for a Role for Serum Response Factor in Prostate Cancer
Authors: Heemers Hannelore V. , Regan Kevin M. , Dehm Scott M. , Tindall Donald J.
Published: March 2023

Supplementary Materials and Methods, Figure Legends 1-5 from Androgen Induction of the Androgen Receptor Coactivator Four and a Half LIM Domain Protein-2: Evidence for a Role for Serum Response Factor in Prostate Cancer
Supplementary Figure 3 from Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3
Authors: Krauß Sybille , Foerster John , Schneider Rainer , Schweiger Susann
Published: March 2023

Supplementary Figure 3 from Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3
Supplementary Figure 1 from Traf1 Induction and Protection from Tumor Necrosis Factor by Nuclear Factor-κB p65 Is Independent of Serine 536 Phosphorylation
Authors: Sasaki Carl Y. , Slemenda Colin F. , Ghosh Paritosh , Barberi Theresa J. , Longo Dan L.
Published: March 2023

Supplementary Figure 1 from Traf1 Induction and Protection from Tumor Necrosis Factor by Nuclear Factor-κB p65 Is Independent of Serine 536 Phosphorylation
Supplementary Table 1 from Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis
Authors: Dourdin Nathalie , Schade Babette , Lesurf Robert , Hallett Michael , Munn Robert J. , Cardiff Robert D. , Muller William J.
Published: March 2023

Supplementary Table 1 from Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis
Supplementary Figure 6 from Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis
Authors: Dourdin Nathalie , Schade Babette , Lesurf Robert , Hallett Michael , Munn Robert J. , Cardiff Robert D. , Muller William J.
Published: March 2023

Supplementary Figure 6 from Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis
Supplementary Table 1 from Hypoxia Down-regulates CCAAT/Enhancer Binding Protein-α Expression in Breast Cancer Cells
Authors: Seifeddine Ramzi , Dreiem Anne , Blanc Etienne , Fulchignoni-Lataud Marie-Claude , Belda Marie-Aude Le Frère , Lecuru Fabrice , Mayi Thérèse Hervèe , Mazure Nathalie , Favaudon Vincent , Massaad Charbel , Barouki Robert , Massaad-Massade Liliane
Published: March 2023

Supplementary Table 1 from Hypoxia Down-regulates CCAAT/Enhancer Binding Protein-α Expression in Breast Cancer Cells
Supplementary Table S1 from Genome-Wide Loss of Heterozygosity and Copy Number Analysis in Melanoma Using High-Density Single-Nucleotide Polymorphism Arrays
Authors: Stark Mitchell , Hayward Nicholas
Published: March 2023

Supplementary Table S1 from Genome-Wide Loss of Heterozygosity and Copy Number Analysis in Melanoma Using High-Density Single-Nucleotide Polymorphism Arrays
Supplementary Table 6 from Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers
Authors: Yamashita Satoshi , Takahashi Satoru , McDonell Nathalie , Watanabe Naoko , Niwa Tohru , Hosoya Kosuke , Tsujino Yoshimi , Shirai Tomoyuki , Ushijima Toshikazu
Published: March 2023

Supplementary Table 6 from Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers
Supplementary Table 2 from Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers
Authors: Yamashita Satoshi , Takahashi Satoru , McDonell Nathalie , Watanabe Naoko , Niwa Tohru , Hosoya Kosuke , Tsujino Yoshimi , Shirai Tomoyuki , Ushijima Toshikazu
Published: March 2023

Supplementary Table 2 from Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers
Supplementary Figure Legends 1-2, Methods from Induction of EBV–Latent Membrane Protein 1–Specific MHC Class II–Restricted T-Cell Responses against Natural Killer Lymphoma Cells
Authors: Kobayashi Hiroya , Nagato Toshihiro , Takahara Miki , Sato Keisuke , Kimura Shoji , Aoki Naoko , Azumi Makoto , Tateno Masatoshi , Harabuchi Yasuaki , Celis Esteban
Published: March 2023

Supplementary Figure Legends 1-2, Methods from Induction of EBV–Latent Membrane Protein 1–Specific MHC Class II–Restricted T-Cell Responses against Natural Killer Lymphoma Cells
Supplementary Figure Legends 1-2 from NOTCH Is Part of the Transcriptional Network Regulating Cell Growth and Survival in Mouse Plasmacytomas
Authors: Shin Dong-Mi , Shaffer Daniel J. , Wang Hongsheng , Roopenian Derry C. , Morse Herbert C.
Published: March 2023

Supplementary Figure Legends 1-2 from NOTCH Is Part of the Transcriptional Network Regulating Cell Growth and Survival in Mouse Plasmacytomas
Supplementary Table 1 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Authors: Kumamoto Kensuke , Spillare Elisa A. , Fujita Kaori , Horikawa Izumi , Yamashita Taro , Appella Ettore , Nagashima Makoto , Takenoshita Seiichi , Yokota Jun , Harris Curtis C.
Published: March 2023

Supplementary Table 1 from Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Supplementary Table 1 from Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies
Authors: Dechant Michael , Weisner Wencke , Berger Sven , Peipp Matthias , Beyer Thomas , Schneider-Merck Tanja , Lammerts van Bueren Jeroen J. , Bleeker Wim K. , Parren Paul W.H.I. , van de Winkel Jan G.J. , Valerius Thomas
Published: March 2023

Supplementary Table 1 from Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies
Supplementary Methods, Figure Legends 1-8 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Authors: Mitsiades Constantine S. , Ocio Enrique M. , Pandiella Atanasio , Maiso Patricia , Gajate Consuelo , Garayoa Mercedes , Vilanova David , Montero Juan Carlos , Mitsiades Nicholas , McMullan Ciaran J. , Munshi Nikhil C. , Hideshima Teru , Chauhan Dharminder , Aviles Pablo , Otero Gabriel , Faircloth Glynn , Mateos M. Victoria , Richardson Paul G. , Mollinedo Faustino , San-Miguel Jesus F. , Anderson Kenneth C.
Published: March 2023

Supplementary Methods, Figure Legends 1-8 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Supplementary Figure Legends 1-4 from A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer
Authors: Bonome Tomas , Levine Douglas A. , Shih Joanna , Randonovich Mike , Pise-Masison Cindy A. , Bogomolniy Faina , Ozbun Laurent , Brady John , Barrett J. Carl , Boyd Jeff , Birrer Michael J.
Published: March 2023

Supplementary Figure Legends 1-4 from A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer
Supplementary Figure 4 from A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer
Authors: Bonome Tomas , Levine Douglas A. , Shih Joanna , Randonovich Mike , Pise-Masison Cindy A. , Bogomolniy Faina , Ozbun Laurent , Brady John , Barrett J. Carl , Boyd Jeff , Birrer Michael J.
Published: March 2023

Supplementary Figure 4 from A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer
Supplementary Figure 1 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Authors: Mitsiades Constantine S. , Ocio Enrique M. , Pandiella Atanasio , Maiso Patricia , Gajate Consuelo , Garayoa Mercedes , Vilanova David , Montero Juan Carlos , Mitsiades Nicholas , McMullan Ciaran J. , Munshi Nikhil C. , Hideshima Teru , Chauhan Dharminder , Aviles Pablo , Otero Gabriel , Faircloth Glynn , Mateos M. Victoria , Richardson Paul G. , Mollinedo Faustino , San-Miguel Jesus F. , Anderson Kenneth C.
Published: March 2023

Supplementary Figure 1 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Supplementary Figure 2 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation
Authors: Marsh Daniel , Dickinson Sarah , Neill Graham W. , Marshall John F. , Hart Ian R. , Thomas Gareth J.
Published: March 2023

Supplementary Figure 2 from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation
Supplementary Figure 1 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma
Authors: Chiba Tetsuhiro , Miyagi Satoru , Saraya Atsunori , Aoki Ryutaro , Seki Atsuyoshi , Morita Yohei , Yonemitsu Yutaka , Yokosuka Osamu , Taniguchi Hideki , Nakauchi Hiromitsu , Iwama Atsushi
Published: March 2023

Supplementary Figure 1 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma
Supplementary Table 2 from Roles of Achaete-Scute Homologue 1 in DKK1 and E-cadherin Repression and Neuroendocrine Differentiation in Lung Cancer
Authors: Osada Hirotaka , Tomida Shuta , Yatabe Yasushi , Tatematsu Yoshio , Takeuchi Toshiyuki , Murakami Hideki , Kondo Yutaka , Sekido Yoshitaka , Takahashi Takashi
Published: March 2023

Supplementary Table 2 from Roles of Achaete-Scute Homologue 1 in DKK1 and E-cadherin Repression and Neuroendocrine Differentiation in Lung Cancer
Supplementary Table 1 from Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays
Authors: Nancarrow Derek J. , Handoko Herlina Y. , Smithers B. Mark , Gotley David C. , Drew Paul A. , Watson David I. , Clouston Andrew D. , Hayward Nicholas K. , Whiteman David C.
Published: March 2023

Supplementary Table 1 from Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays
Supplementary Table 1 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Authors: Kikuchi Ryoko , Tsuda Hitoshi , Kozaki Ken-ichi , Kanai Yae , Kasamatsu Takahiro , Sengoku Kazuo , Hirohashi Setsuo , Inazawa Johji , Imoto Issei
Published: March 2023

Supplementary Table 1 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Supplementary Figure 1 from Signal Transducers and Activators of Transcription Mediate Fibroblast Growth Factor–Induced Vascular Endothelial Morphogenesis
Authors: Yang Xinhai , Qiao Dianhua , Meyer Kristy , Friedl Andreas
Published: March 2023

Supplementary Figure 1 from Signal Transducers and Activators of Transcription Mediate Fibroblast Growth Factor–Induced Vascular Endothelial Morphogenesis
Data from Homeobox Msx1 Interacts with p53 Tumor Suppressor and Inhibits Tumor Growth by Inducing Apoptosis
Authors: Park Kyoungsook , Kim Kwangbae , Rho Seung Bae , Choi Kyusam , Kim Dojin , Oh Sun-Hee , Park Jinhee , Lee Seung-Hoon , Lee Je-Ho
Published: March 2023

Abstract
The stability of wild-type p53 is critical for its apoptotic function. In some cancers, wild-type p53 is inactivated by interaction with viral and cellular proteins, and restoration of its activity has therapeutic potential. Here, we identify homeobox Msx1 as a p53-interacting protein and show its novel function as a p53 regulator. Overexpression of homeobox Msx1 induced apoptosis of cancer cells harboring nonfunctional wild-type p53 and suppressed growth of human tumor xenografts in nude mice. The homeodomain of Msx1 functions as a protein-protein interacting motif rather than a DNA-binding domain and is essential for stabilization, nuclear accumulation, and apoptotic function of wild-type p53. The identification of a novel function of Msx1 as a p53 regulator may open new avenues for developing improved molecular therapies for tumors with a nonmutational p53 inactivation mechanism.
Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
Authors: Zhao Zibo , Szczepanski Aileen P. , Tsuboyama Natsumi , Abdala-Valencia Hiam , Goo Young Ah , Singer Benjamin D. , Bartom Elizabeth T. , Yue Feng , Wang Lu
Published: March 2023

Abstract
Abnormalities in genetic and epigenetic modifications can lead to drastic changes in gene expression profiles that are associated with various cancer types. Small cell lung cancer (SCLC) is an aggressive and deadly form of lung cancer with limited effective therapies currently available. By utilizing a genome-wide CRISPR-Cas9 dropout screen in SCLC cells, we identified paired box protein 9 (PAX9) as an essential factor that is overexpressed in human malignant SCLC tumor samples and is transcriptionally driven by the BAP1/ASXL3/BRD4 epigenetic axis. Genome-wide studies revealed that PAX9 occupies distal enhancer elements and represses gene expression by restricting enhancer activity. In multiple SCLC cell lines, genetic depletion of PAX9 led to significant induction of a primed-active enhancer transition, resulting in increased expression of a large number of neural differentiation and tumor-suppressive genes. Mechanistically, PAX9 interacted and cofunctioned with the nucleosome remodeling and deacetylase (NuRD) complex at enhancers to repress nearby gene expression, which was reversed by pharmacologic HDAC inhibition. Overall, this study provides mechanistic insight into the oncogenic function of the PAX9/NuRD complex epigenetic axis in human SCLC and suggests that reactivation of primed enhancers may have potential therapeutic efficacy in treating SCLC expressing high levels of PAX9.
Significance:
A genome-wide screen in small cell lung cancer reveals PAX9/NuRD-mediated epigenetic enhancer silencing and tumor progression, supporting the development of novel personalized therapeutic approaches targeting the PAX9-regulated network.
Data from P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells
Authors: Paredes Joana , Stove Christophe , Stove Veronique , Milanezi Fernanda , Van Marck Veerle , Derycke Lara , Mareel Marc , Bracke Marc , Schmitt Fernando
Published: March 2023

Abstract
P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-α, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-α signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-α signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.
Data from Early Growth Response 1 Acts as a Tumor Suppressor In vivo and In vitro via Regulation of p53
Authors: Krones-Herzig Anja , Mittal Shalu , Yule Kelly , Liang Hongyan , English Chris , Urcis Rafael , Soni Tarun , Adamson Eileen D. , Mercola Dan
Published: March 2023

Abstract
The early growth response 1 (Egr1) gene is a transcription factor that acts as both a tumor suppressor and a tumor promoter. Egr1-null mouse embryo fibroblasts bypass replicative senescence and exhibit a loss of DNA damage response and an apparent immortal growth, suggesting loss of p53 functions. Stringent expression analysis revealed 266 transcripts with >2-fold differential expression in Egr1-null mouse embryo fibroblasts, including 143 known genes. Of the 143 genes, program-assisted searching revealed 66 informative genes linked to Egr1. All 66 genes could be placed on a single regulatory network consisting of three branch points of known Egr1 target genes: TGFβ1, IL6, and IGFI. Moreover, 19 additional genes that are known targets of p53 were identified, indicating that p53 is a fourth branch point. Electrophoretic mobility shift assay as well as chromatin immunoprecipitation confirmed that p53 is a direct target of Egr1. Because deficient p53 expression causes tumors in mice, we tested the role of Egr1 in a two-step skin carcinogenesis study (144 mice) that revealed a uniformly accelerated development of skin tumors in Egr1-null mice (P < 0.005). These studies reveal a new role for Egr1 as an in vivo tumor suppressor.
Data from Frequent Nonrandom Activation of Germ-Line Genes in Human Cancer
Authors: Koslowski Michael , Bell Carolin , Seitz Gerhard , Lehr Hans-Anton , Roemer Klaus , Müntefering Horst , Huber Christoph , Sahin Ugur , Türeci Özlem
Published: March 2023

Abstract
The growing class of cancer/germ-line genes is characterized by a unique expression pattern with transcription restricted to germ cells and cancer cells. It is not known which fraction of germ-line genes is ectopically activated in tumor cells and whether this fraction displays common features as compared with strictly germ-line genes remaining silent in cancer. Using an unbiased genome-wide scanning approach, representative samples of both cancer/germ-line genes as well as strictly germ-line-specific genes were determined. Comparative analysis disclosed highly significant diametric characteristics for these two categories of genes with regard to sex specificity, developmental stage of physiological expression during gametogenesis, chromosomal localization, and epigenetic regulation of expression. Our findings provide class predictors for germ cell-specific gene activation in cancer. The identification of highly congruent expression patterns in cancer and in DNA methyltransferase-deficient cells suggests an underlying common epigenetic mechanism for activation of germ-line genes in cancer.
Data from Transforming Growth Factor β Receptor Type II Inactivation Promotes the Establishment and Progression of Colon Cancer
Authors: Biswas Swati , Chytil Anna , Washington Kay , Romero-Gallo Judith , Gorska Agnieszka E. , Wirth Pamela S. , Gautam Shiva , Moses Harold L. , Grady William M.
Published: March 2023

Abstract
Deregulation of members of the transforming growth factor (TGF)-β signaling pathway occurs often in colon cancers and is believed to affect the formation of primary colon cancer. Mutational inactivation of TGFBR2 is the most common genetic event affecting the TGF-β signaling pathway and occurs in ∼20–30% of all colon cancers. By mating Fabpl4xat-132 Cre mice with Tgfbr2flx/flx mice, we have generated a mouse model that is null for Tgfbr2 in the colonic epithelium, and in this model system, we have assessed the effect of loss of TGF-β signaling in vivo on colon cancer formation induced by azoxymethane (AOM). We have observed a significant increase in the number of AOM-induced adenomas and adenocarcinomas in the Fabpl4xat-132 Cre Tgfbr2flx/flx mice compared with Tgfbr2flx/flx mice, which have intact TGF-β receptor type II (TGFBR2) in the colon epithelium, and we have found increased proliferation in the neoplasms occurring in the Fabpl4xat-132 Cre Tgfbr2flx/flx mice. These results implicate the loss of TGF-β-mediated growth inhibition as one of the in vivo mechanisms through which TGFBR2 inactivation contributes to colon cancer formation. Thus, we have demonstrated that loss of TGFBR2 in colon epithelial cells promotes the establishment and progression of AOM-induced colon neoplasms, providing evidence from an in vivo model system that TGFBR2 is a tumor suppressor gene in the colon.