bluuebunny/crossref_metadata_2025 huggingface dataset:
The Interleukin-17 Family of Cytokines in Breast Cancer
Authors: Fabre Joseph , Giustiniani Jérôme , Garbar Christian , Merrouche Yacine , Antonicelli Frank , Bensussan Armand
Published: December 2018

Breast cancer (BC) is the most common cancer in women worldwide and remains a major cause of mortality with an expected 137,000 death this year in Europe. Standard management of metastatic BC comprises hormonotherapy, chemotherapy, and targeted therapies. Cyclin dependent kinase (CDK) and mammalian target of rapamycin (mTOR) inhibitors have recently proved their efficiency in hormonal receptor expressing BC. Checkpoint proteins inhibition is being evaluated in phase 3 studies. Since inflammation is constantly present in cancers, research teams have focused their attention on the interleukin-17 (IL-17) family of proinflammatory cytokines. Preclinical experiments have reported both pro and antitumor effects depending on the conditions. In the present article, we review the accumulating evidences about the roles of IL-17 in BC and discuss whether this family of cytokines could be a new target in anticancer treatments.
Targeted Contrast Agents for Molecular MRI
Authors: Lacerda Sara
Published: December 2018

Molecular magnetic resonance imaging (MRI) provides information non-invasively at cellular and molecular levels, for both early diagnosis and monitoring therapeutic follow-up. This imaging technique requires the development of a new class of contrast agents, which signal changes (typically becomes enhanced) when in presence of the cellular or molecular process to be evaluated. Even if molecular MRI has had a prominent role in the advances in medicine over the past two decades, the large majority of the developed probes to date are still in preclinical level, or eventually in phase I or II clinical trials. The development of novel imaging probes is an emergent active research domain. This review focuses on gadolinium-based specific-targeted contrast agents, providing rational design considerations and examples of the strategies recently reported in the literature.
Effect of Different Light Spectrum in Helicoverpa armigera Larvae during HearNPV Induced Tree-Top Disease
Authors: Bhattarai Mandira Katuwal , Bhattarai Upendra Raj , Feng Ji-nian , Wang Dun
Published: December 2018

Lepidopteran larvae upon infection by baculovirus show positive photo-tactic movement during tree-top disease. In light of many insects exploiting specific spectral information for the different behavioral decision, each spectral wavelength of light is an individual parsimonious candidate for such behavior stimulation. Here, we investigated the responses of third instar Helicoverpa armigera larvae infected by Helicoverpa armigera nucleopolyhedrovirus (HearNPV) to white (broad-spectrum), blue (450–490 nm), UVA (320–400 nm), and UVB (290–320 nm) lights for the tree-top disease. Our findings suggest that tree-top phenomenon is induced only when the light is applied from above. Blue, white and UVA lights from above induced tree-top disease, causing infected larvae to die in an elevated position compared to those larvae living in the complete dark. In contrast, UVB from above did not induce tree-top disease. Blue light exerted the maximum photo-tactic response, significantly (p < 0.01) higher than white light. The magnitude of the response decreased with decreasing wavelength to UVA, and no response at UVB. Our results suggested that the spectral wavelength of the light has a significant effect on the induction of the tree-top disease in H. armigera third instar larvae infected with HearNPV.
Microfluidic Deformability Study of an Innovative Blood Analogue Fluid Based on Giant Unilamellar Vesicles
Authors: Carvalho Denise A. M. , Rodrigues Ana Rita O. , Faustino Vera , Pinho Diana , Castanheira Elisabete M. S. , Lima Rui
Published: December 2018

Blood analogues have long been a topic of interest in biofluid mechanics due to the safety and ethical issues involved in the collection and handling of blood samples. Although the current blood analogue fluids can adequately mimic the rheological properties of blood from a macroscopic point of view, at the microscopic level blood analogues need further development and improvement. In this work, an innovative blood analogue containing giant unilamellar vesicles (GUVs) was developed to mimic the flow behavior of red blood cells (RBCs). A natural lipid mixture, soybean lecithin, was used for the GUVs preparation, and three different lipid concentrations were tested (1 × 10−3 M, 2 × 10−3 M and 4 × 10−3 M). GUV solutions were prepared by thin film hydration with a buffer, followed by extrusion. It was found that GUVs present diameters between 5 and 7 µm which are close to the size of human RBCs. Experimental flow studies of three different GUV solutions were performed in a hyperbolic-shaped microchannel in order to measure the GUVs deformability when subjected to a homogeneous extensional flow. The result of the deformation index (DI) of the GUVs was about 0.5, which is in good agreement with the human RBC’s DI. Hence, the GUVs developed in this study are a promising way to mimic the mechanical properties of the RBCs and to further develop particulate blood analogues with flow properties closer to those of real blood.
Spatial Referencing of Hyperspectral Images for Tracing of Plant Disease Symptoms
Authors: Behmann Jan , Bohnenkamp David , Paulus Stefan , Mahlein Anne-Katrin
Published: December 2018

The characterization of plant disease symptoms by hyperspectral imaging is often limited by the missing ability to investigate early, still invisible states. Automatically tracing the symptom position on the leaf back in time could be a promising approach to overcome this limitation. Therefore we present a method to spatially reference time series of close range hyperspectral images. Based on reference points, a robust method is presented to derive a suitable transformation model for each observation within a time series experiment. A non-linear 2D polynomial transformation model has been selected to cope with the specific structure and growth processes of wheat leaves. The potential of the method is outlined by an improved labeling procedure for very early symptoms and by extracting spectral characteristics of single symptoms represented by Vegetation Indices over time. The characteristics are extracted for brown rust and septoria tritici blotch on wheat, based on time series observations using a VISNIR (400–1000 nm) hyperspectral camera.
Precision Permittivity Measurement for Low-Loss Thin Planar Materials Using Large Coaxial Probe from 1 to 400 MHz
Authors: You Kok Yeow , Sim Man Seng
Published: December 2018

This paper focuses on the non-destructive dielectric measurement for low-loss planar materials with a thickness of less than 3 mm using a large coaxial probe with an outer diameter of 48 mm. The aperture probe calibration procedure required only to make a measurement of the half-space air and three offset shorts. The reflection coefficient for the thin material is measured using a Keysight E5071C network analyzer from 0.3 MHz to 650 MHz and then converted to a relative dielectric constant, εr and tangent loss, tan δ via closed form capacitance model and lift-off calibration process. Average measurement error of dielectric constant, Δεr is less than 6% from 1 MHz to 400 MHz and the resolution of loss tangent, tan δ measurement is capable of achieving 10−3.
Structure and Electron Mobility of ScN Films Grown on α-Al2O3(1102) Substrates
Authors: Ohgaki Takeshi , Sakaguchi Isao , Ohashi Naoki
Published: December 2018

Scandium nitride (ScN) films were grown on α-Al2O3( 1 1 ¯ 02 ) substrates using the molecular beam epitaxy method, and the heteroepitaxial growth of ScN on α-Al2O3( 1 1 ¯ 02 ) and their electric properties were studied. Epitaxial ScN films with an orientation relationship (100)ScN || ( 1 1 ¯ 02 )α-Al2O3 and [001]ScN || [ 11 2 ¯ 0 ]α-Al2O3 were grown on α-Al2O3( 1 1 ¯ 02 ) substrates. Their crystalline orientation anisotropy was found to be small. In addition, [100] of the ScN films were tilted along [ 1 ¯ 101 ] of α-Al2O3( 1 1 ¯ 02 ) in the initial stage of growth. The tilt angle between the film growth direction and [100] of ScN was 1.4–2.0° and increased with growth temperature. The crystallinity of the ScN films also improved with the increasing growth temperature. The film with the highest Hall mobility was obtained at the boundary growth conditions determined by the relationship between the crystallinity and the nonstoichiometric composition because the film with the highest crystallinity was obtained under the Sc-rich growth condition. The decreased Hall mobility with a simultaneous improvement in film crystallinity was caused by the increased carrier scattering by the ionized donors originating from the nonstoichiometric composition.
Thermal Decomposition and Thermal Reaction Process of PTFE/Al/MnO2 Fluorinated Thermite
Authors: Zhang Jun , Huang Junyi , Fang Xiang , Li Yuchun , Yu Zhongshen , Gao Zhenru , Wu Shuangzhang , Yang Li , Wu Jiaxiang , Kui Jiaying
Published: December 2018

To better understand the thermal decomposition and reaction process of a fluorine-containing powdery thermite, PTFE/Al/MnO2, reactions at different temperatures were investigated by the TG/DSC-MS technique. The corresponding reaction products were characterized with XRD phase analysis. Another three thermite materials, i.e., PTFE/Al, Al/MnO2, and PTFE/MnO2, were also prepared for comparison. Results showed that PTFE behaved as both oxidizer and reducer in PTFE/Al/MnO2 fluorinated thermite. The thermal decomposition and reaction process of as-fabricated ternary thermite could be divided into two stages—the mutual reaction between each of PTFE, Al, and MnO2 and the subsequent reaction produced between Al and Mn2O3/Mn3O4/MnF2. Compared with the three control systems, the specially designed ternary system possessed a shorter reaction time, a faster energy release rate, and a better heat release performance.
Facile Synthesis of Visible Light-Induced g-C3N4/Rectorite Composite for Efficient Photodegradation of Ciprofloxacin
Authors: Sun Zhiming , Zhang Xiangwei , Zhu Rui , Dong Xiongbo , Xu Jie , Wang Bin
Published: December 2018

A novel kind of g-C3N4/rectorite composite with high visible-light photoactivity was developed via a mild and cost effective two-step process. Ciprofloxacin (CIP), a typical antibiotic, was applied to evaluate the photoactivity of the received catalysts. Furthermore, the by-products of CIP photodegradation were analyzed and the possible degradation pathways were also discussed. Compared with bare photocatalysts, the received composite possessed well reusability and higher photoactivity towards CIP. According to the characterization analysis results, layered g-C3N4 was successfully immobilized on layered rectorite, which could not only promote its adsorption capacity but also provide more reactive sites for CIP adsorption and photodegradation. Compared with bare g-C3N4, the photoactivity of the prepared composite was significantly enhanced. The enhancement should be mainly due to the lower recombination rate of photogenerated carriers and the improved adsorption capacity toward CIP. This study demonstrated that the obtained g-C3N4/rectorite composite should be a promising alternative material in wastewater treatment.
Influence of Gradual Damage on the Structural Dynamic Behaviour of Composite Rotors: Simulation Assessment
Authors: Filippatos Angelos , Langkamp Albert , Gude Maik
Published: December 2018

Fibre-reinforced composite structures under complex loads exhibit gradual damage behaviour with degradation of effective mechanical properties and change of their structural dynamic behaviour. In case of composite rotors, this can lead to catastrophic failure if an eigenfrequency is met by the rotational speed. The description and simulation analysis of the gradual damage behaviour of composite rotors therefore provides the fundamentals for a first understanding of complex and partially-unpredicted structural phenomena. Therefore, a simulation tool is developed using a finite element model, which calculates the damage-dependent structural dynamic behaviour of selected composite rotors considering both damage initiation and in-plane damage evolution due to a combination of out-of-plane and in-plane loads. Damage initiation is determined using failure criteria, whereas the gradual damage evolution using a validated continuum damage mechanics model. Numerical results are compared with experimental results for rotor-typical stress states to assess the model quality, which could be later used for damage identification approaches.
A Combined Approach of Double Network Hydrogel and Nanocomposites Based on Hyaluronic Acid and Poly(ethylene glycol) Diacrylate Blend
Authors: Ronca Alfredo , D’Amora Ugo , Raucci Maria Grazia , Lin Hai , Fan Yujiang , Zhang Xingdong , Ambrosio Luigi
Published: December 2018

In this study, an innovative polymer blend, based on double network (DN) approach, has been developed by integrating a poly(ethylene glycol) diacrylate (PEGDA) network into a chemically modified hyaluronic acid sodium salt (HAs) hydrogel matrix. Here, the HAs was chemically functionalized with photocrosslinkable moieties by reacting with maleic anhydride (MAA) to obtain a maleated hyaluronic acid (MaHA). Furthermore, nanocomposite DN hydrogels were suitably prepared by physical blending of hydroxyapatite nanoparticles (HAp), obtained by sol-gel synthesis, within the hydrogel. Physico-chemical, thermal, morphological and mechanical analyses were performed. Results showed enhanced mechanical properties and a homogenous microstructure as highlighted by mechanical and morphological investigations. This suggests that nanocomposite DN hydrogels are promising candidates for biomedical applications.
Nanoclay Intercalation During Foaming of Polymeric Nanocomposites Studied in-Situ by Synchrotron X-Ray Diffraction
Authors: Bernardo Victoria , Mugica Mikel , Perez-Tamarit Saul , Notario Belen , Jimenez Catalina , Rodriguez-Perez Miguel Angel
Published: December 2018

The intercalation degree of nanoclays in polymeric foamed nanocomposites containing clays is a key parameter determining the final properties of the material, but how intercalation occurs is not fully understood. In this work, energy dispersive X-ray diffraction (ED-XRD) of synchrotron radiation was used as an in-situ technique to deepen into the intercalation process of polymer/nanoclay nanocomposites during foaming. Foamable nanocomposites were prepared by the melt blending route using low-density polyethylene (LDPE), polypropylene (PP), and polystyrene (PS) with surface treated nanoclays and azodicarbonamide (ADC) as the blowing agent. Foaming was induced by heating at atmospheric pressure. The time and temperature evolution of the interlamellar distance of the clay platelets in the expanding nanocomposites was followed. Upon foaming, interlamellar distances of the nanocomposites based on LDPE and PP increase by 18% and 16% compared to the bulk foamable nanocomposite. Therefore, the foaming process enhances the nanoclay intercalation degree in these systems. This effect is not strongly affected by the type of nanoclay used in LDPE, but by the type of polymer used. Besides, the addition of nanoclays to PP and PS has a catalytic effect on the decomposition of ADC, i.e., the decomposition temperature is reduced, and the amount of gas released increases. This effect was previously proved for LDPE.
Sustainable Supplier Selection Process in Edible Oil Production by a Hybrid Fuzzy Analytical Hierarchy Process and Green Data Envelopment Analysis for the SMEs Food Processing Industry
Authors: Wang Chia-Nan , Nguyen Van Thanh , Thai Hoang Tuyet Nhi , Tran Ngoc Nguyen , Tran Thi Lan Anh
Published: December 2018

Today, business organizations are facing increasing pressure from a variety of sources to operate using sustainable processes. Thus, most companies need to focus on their supply chains to enhance sustainability to meet customer demands and comply with environmental legislation. To achieve these goals, companies must focus on criteria that include CO2 (carbon footprint) and toxic emissions, energy use and efficiency, wastage generations, and worker health and safety. As in other industries, the food processing industry requires large inputs of resources, which results in several negative environmental effects; thus, decision-makers have to evaluate qualitative and quantitative factors. This work identifies the best supplier for edible oil production in the small and medium enterprise (SME) food processing industry in Vietnam. This study also processes a hybrid multicriteria decision-making (MCDM) model using a fuzzy analytical hierarchy process (FAHP) and green data envelopment analysis (GDEA) model to identify the weight of all criteria of a supplier’s selection process based on opinions from company procurement experts. Subsequently, GDEA is applied to rank all potential supplier lists. The primary objective of this work is to present a novel approach which integrates FAHP and DEA for supplier selection and also consider the green issue in edible oil production in uncertain environments. The aim of this research is also to provide a useful guideline for supplier selection based on qualitative and quantitative factors to improve the efficiency of supplier selection in the food industry and other industries. The results reveal that Decision-Making Unit 1 (DMU 1), DMU 3, DMU 7, and DMU 9 are identified as extremely efficient for five DEA models, which are the optimal suppliers for edible oil production. The contributions of this research include a proposed MCDM model using a hybrid FAHP and GDEA model for supplier selection in the SME food processing industry under a fuzzy environment conditions in Vietnam. This research also is part of an evolution of a new hybrid model that is flexible and practical for decision-makers. In addition, the research also provides a useful guideline in supplier selection in the food processing industry and a guideline for supplier selection in other industries.
New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915
Authors: Liu Shun-Zhi , Yan Xia , Tang Xi-Xiang , Lin Jin-Guo , Qiu Ying-Kun
Published: December 2018

Fusarium solani H915 is a fungus derived from mangrove sediments. From its ethyl acetate extract, a new alkenoic acid, fusaridioic acid A (1), three new bis-alkenoic acid esters, namely, fusariumester A1 (2), A2 (3) and B (4), together with three known compounds (5–7), were isolated. The structures of the new compounds were comprehensively characterized by high resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). Additionally, the antifungal activities against tea pathogenic fungi Pestalotiopsis theae and Colletotrichum gloeosporioides were studied. The new compound, 4, containing a β-lactone ring, exhibited moderate inhibitory activity against P. theae, with an MIC of 50 μg/disc. Hymeglusin (6), a typical β-lactone antibiotic and a terpenoid alkaloid, equisetin (7), exhibited potent inhibitory activities against both fungal species. The isolated compounds were evaluated for their effects on zebrafish embryo development. Equisetin clearly imparted toxic effect on zebrafish even at low concentrations. However, none of the alkenoic acid derivatives exhibited significant toxicity to zebrafish eggs, embryos, or larvae. Thus, the β-lactone containing alkenoic acid derivatives from F. solani H915 are low in toxicity and are potent antifungal agents against tea pathogenic fungi.
Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth
Authors: Raimundo Inês , Silva Sandra G. , Costa Rodrigo , Keller-Costa Tina
Published: December 2018

Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from Eunicella spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties.
Algal Oxylipins Mediate the Resistance of Diatoms against Algicidal Bacteria
Authors: Meyer Nils , Rettner Johanna , Werner Markus , Werz Oliver , Pohnert Georg
Published: December 2018

Algicidal bacteria can lyse microalgal blooms and trigger shifts within plankton communities. Resistant algal species can escape lysis, and have the opportunity to dominate the phytoplankton after a bacterial infection. Despite their important function in ecosystem regulation, little is known about mechanisms of resistance. Here, we show that the diatom Chaetoceros didymus releases eicosanoid oxylipins into the medium, and that the lytic algicidal bacterium, Kordia algicida, induces the production of several wound-activated oxylipins in this resistant diatom. Neither releases nor an induction occurs in the susceptible diatom Skeletonema costatum that is lysed by the bacterium within a few days. Among the upregulated oxylipins, hydroxylated eicosapentaenoic acids (HEPEs) dominate. However, also, resolvins, known lipid mediators in mammals, increase upon exposure of the algae to the algicidal bacteria. The prevailing hydroxylated fatty acid, 15-HEPE, significantly inhibits growth of K. algicida at a concentration of approximately 1 µM. The oxylipin production may represent an independent line of defense of the resistant alga, acting in addition to the previously reported upregulation of proteases.
Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies
Authors: Mozaffari Hamid Reza , Zavattaro Elisa , Abdolahnejad Abas , Lopez-Jornet Pia , Omidpanah Neda , Sharifi Roohollah , Sadeghi Masoud , Shooriabi Mohammad , Safaei Mohsen
Published: December 2018

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle–Ottawa Quality Assessment Scale (NOS) questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Out of 70 studies found in the databases, 8 studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of IgA, IgG, and IgM were −0.13 g/L [95% CI: −0.24, −0.02; P = 0.02], 1.01 g/L [95% CI: −0.91, 2.93; P = 0.30], and −0.06 g/L [95% CI: −0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95% CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95% CI: −0.20, 1.38; P = 0.14], respectively. Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had higher values than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.
Welding of Dissimilar Steel/Al Joints Using Dual-Beam Lasers with Side-by-Side Configuration
Authors: Cui Li , Chen Hongxi , Chen Boxu , He Dingyong
Published: December 2018

Welding of dissimilar steel/Al lapped joints of 1.5 mm in thickness was carried out by using dual-beam laser welding with side-by-side configuration. The effect of the major process parameters including the dual-beam power ratio of (Rs) and dual-beam distance (d1) on the steel/Al joint characteristics was investigated concerning the weld shape, interface microstructures, tensile resistance and fracture behavior. The results show that dual-beam laser welding with side-by-side configuration produces soundly welded steel/Al lapped joints free of welding defects. The processing parameters of Rs and d1 have a great influence on the weld appearance, the weld penetration in the Al alloy side (P2) and the welding defects. Variation in the depth of the P2 and the locations at the Al/weld interface cause heterogeneous microstructures in the morphology and the thickness of the intermetallic compound (IMC) layers. In addition, electron back scattered diffraction (EBSD) phase mapping reveals that the IMC layer microstructures formed at the Al/weld interface include the needle-like θ-Fe4Al13 phases and compact lath η-Fe2Al5 layers. Some very fine θ-Fe4Al13 and η-Fe2Al5 phases generated along the weld grain boundaries of the steel/Al joints are also confirmed. Finally, there is a matching relationship between the P2 and the tensile resistance of steel/Al joints, and the maximum tensile resistance of 109.2 N/mm is obtained by the steel/Al joints produced at the Rs of 1.50 during dual-beam laser welding with side-by-side configuration. Two fracture path modes have taken place depending on the P2, and relatively high resistance has been achieved for the steel/Al joints with an optimum P2.
Metallic Films: From Nanofabrication and Nanostructuration to Characterizations and Applications
Authors: Ruffino Francesco
Published: December 2018

Metallic films are key components in many modern technologies, from integrated circuits to sensors. [...]
Analysis of Failure-Mode Dependent Joint Strength in Hole Clinching from the Aspects of Geometrical Interlocking Parameters
Authors: Lee Chan-Joo , Shen Guo , Kim Byung-Min , Lambiase Francesco , Ko Dae-Cheol
Published: December 2018

The hole-clinching process is one of the mechanical methods for joining dissimilar materials, such as aluminum alloy with advanced high-strength steel, hot-pressed steel, and carbon fiber reinforced plastics, employing forming technology-based methods. In joint design, the analysis of the failure-mode dependent joint strength is a crucial step in achieving structural performance for practical applications. In this study, the influence of the geometrical interlocking parameters on the failure-mode dependent joint strength was investigated in order to design the geometrical interlocking shape of the hole-clinched joint to achieve a target joint strength. Moreover, the failure process of the hole-clinched joint under pullout loading condition was studied to determine the geometrical interlocking parameters that affect joint strength. Based on the results of the finite element analysis, an analytical approach for the failure-mode dependent joint strength was proposed to predict the strength of the hole-clinched joint. In addition, the proposed analytical approach was applied to the hole-clinching process with dissimilar materials. Its effectiveness was then verified using the cross-tension test. Accordingly, it was found that it was possible to predict the failure modes and joint strength with a maximum error of 7.8%.
Mineralogical and Geochemical Features of Cretaceous Bauxite from San Giovanni Rotondo (Apulia, Southern Italy): A Provenance Tool
Authors: Sinisi Rosa
Published: December 2018

In this study, the mineralogical and chemical compositions of bauxite from San Giovanni Rotondo (SGR) on the Gargano Promontory (northern Apulia, Italy) are presented and discussed with the aim of assessing the nature of its source material. Bauxite from the SGR, which is known as the “Montecatini mine”, was exploited intensively until the 1970s to recover alumina. As with most of the autochthonous peri-Mediterranean bauxites, the studied deposit is a karst bauxite with a massive, matrix-supported texture and an oolitic structure. Boehmite and hematite are the main mineral phases, and anatase, rutile, and kaolinite are present in lesser amounts along with detrital zircons and monazite grains. Calcite is abundant only in the deposit’s lower portion, triggering a significant dilution effect on trace element concentrations. However, with respect to the average crust and chondrite compositions, strong enrichments of trace metals (up to 10X Upper Continental Crust’s (UCC)) and rare earth elements (REEs, up to 800X chondrite) exist throughout the studied deposit. The distribution of REEs, the (La/Yb)N and Eu/Eu* ratios, and an Eu/Eu* versus Sm/Nd diagram have been used for determining the bauxite’s provenance. These geochemical proxies point to a parental material consisting of a mixture of distant magmatic and siliciclastic components.
Selective Flotation of Pyrite from Arsenopyrite by Low Temperature Oxygen Plasma Pre-Treatment
Authors: Ran Jincheng , Qiu Xianyang , Hu Zhen , Liu Quanjun , Song Baoxu
Published: December 2018

In this study, the surface modification of arsenopyrite and pyrite with low temperature oxygen plasma was developed as an effective approach to improve the flotation separation efficiency of minerals. The micro-flotation experiments results indicated that plasma pre-treatment can achieve selective flotation of arsenopyrite from pyrite. The XPS analysis results indicated that the oxidation degree of plasma-modification arsenopyrite surface is much higher than that of pyrite. A large number of sulfide components on the surface of the mineral were oxidized to highly-valence hydrophilic oxides by plasma pre-treatment. ICP-MS analysis results revealed that the dissolution rate was determined by the oxidation degree of minerals and plasma modified accelerated the dissolution of arsenopyrite and pyrite. Zeta potential determination results confirmed that plasma can keep a relatively higher adsorption of SBX on the pyrite surface but inhibit the adsorption of collector onto the arsenopyrite surface.
Synchrotron Diffraction Study of the Crystal Structure of Ca(UO2)6(SO4)2O2(OH)6·12H2O, a Natural Phase Related to Uranopilite
Authors: Krivovichev Sergey V. , Meisser Nicolas , Brugger Joel , Chernyshov Dmitry V. , Gurzhiy Vladislav V.
Published: December 2018

The crystal structure of a novel natural uranyl sulfate, Ca(UO2)6(SO4)2O2(OH)6·12H2O (CaUS), has been determined using data collected under ambient conditions at the Swiss–Norwegian beamline BM01 of the European Synchrotron Research Facility (ESRF). The compound is monoclinic, P21/c, a = 11.931(2), b = 14.246(6), c = 20.873(4) Å, β = 102.768(15), V = 3460.1(18) Å3, and R1 = 0.172 for 3805 unique observed reflections. The crystal structure contains six symmetrically independent U6+ atoms forming (UO7) pentagonal bipyramids that share O…O edges to form hexamers oriented parallel to the (010) plane and extended along [1–20]. The hexamers are linked via (SO4) groups to form [(UO2)6(SO4)2O2(OH)6(H2O)4]2− chains running along the c-axis. The adjacent chains are arranged into sheets parallel to (010). The Ca2+ ions are coordinated by seven O atoms, and are located in between the sheets, providing their linkage into a three-dimensional structure. The crystal structure of CaUS is closely related to that of uranopilite, (UO2)6(SO4)O2(OH)6·14H2O, which is also based upon uranyl sulfate chains consisting of hexameric units formed by the polymerization of six (UO7) pentagonal bipyramids. However, in uranopilite, each (SO4) tetrahedron shares its four O atoms with (UO7) bipyramids, whereas in CaUS, each sulfate group is linked to three uranyl ions only, and has one O atom (O16) linked to the Ca2+ cation. The chains are also different in the U:S ratio, which is equal to 6:1 for uranopilite and 3:1 for CaUS. The information-based structural complexity parameters for CaUS were calculated taking into account H atoms show that the crystal structure of this phase should be described as very complex, possessing 6.304 bits/atom and 1991.995 bits/cell. The high structural complexity of CaUS can be explained by the high topological complexity of the uranyl sulfate chain based upon uranyl hydroxo/oxo hexamers and the high hydration character of the phase.
The Link between Soil Geochemistry in South-West England and Human Exposure to Soil Arsenic
Authors: Wragg Joanna , Cave Mark , Hamilton Elliott , Lister T. Robert
Published: December 2018

The aim of this research is to use the whole soil geochemistry and selected bioaccessibility measurements, using the BioAcessibility Research Group of Europe (BARGE) method, on the same soils to identify the geochemical controls on arsenic (As) bioaccessibility and to gain an understanding of its spatial distribution in south-west England. The total element concentrations of 1154 soils were measured with As concentrations ranging from 4.7–1948 mg·kg−1, with the bioaccessible As of 50 selected soils ranging from 0.6–237 mg·kg−1. A Self Modelling Mixture Resolution approach was applied to the total soil element chemistry to identify the intrinsic soil constituents (ISCs). The ISCs were used as predictor variables and As bioaccessibility as the dependant variables in a regression model for the prediction of As bioaccessibility at all soil locations to examine its regional spatial distribution. This study has shown that bioaccessibility measurements can be directly linked to the geochemical properties of soils. In summary, it seems the primary source of bioaccessible As comes from soils developed directly over the mineralised areas surrounding the granite intrusions. Secondary sources of bioaccessible As are derived from As that has been mobilised from the primary mineralised source and then re-absorbed onto clay material, Fe oxides and carbonate coatings. This information can be of direct use for land development, since land contamination can affect the health of people living, working, visiting or otherwise present on a site.
Inorganic Salts and Antimicrobial Photodynamic Therapy: Mechanistic Conundrums?
Authors: Hamblin Michael R. , Abrahamse Heidi
Published: December 2018

We have recently discovered that the photodynamic action of many different photosensitizers (PSs) can be dramatically potentiated by addition of a solution containing a range of different inorganic salts. Most of these studies have centered around antimicrobial photodynamic inactivation that kills Gram-negative and Gram-positive bacteria in suspension. Addition of non-toxic water-soluble salts during illumination can kill up to six additional logs of bacterial cells (one million-fold improvement). The PSs investigated range from those that undergo mainly Type I photochemical mechanisms (electron transfer to produce superoxide, hydrogen peroxide, and hydroxyl radicals), such as phenothiazinium dyes, fullerenes, and titanium dioxide, to those that are mainly Type II (energy transfer to produce singlet oxygen), such as porphyrins, and Rose Bengal. At one extreme of the salts is sodium azide, that quenches singlet oxygen but can produce azide radicals (presumed to be highly reactive) via electron transfer from photoexcited phenothiazinium dyes. Potassium iodide is oxidized to molecular iodine by both Type I and Type II PSs, but may also form reactive iodine species. Potassium bromide is oxidized to hypobromite, but only by titanium dioxide photocatalysis (Type I). Potassium thiocyanate appears to require a mixture of Type I and Type II photochemistry to first produce sulfite, that can then form the sulfur trioxide radical anion. Potassium selenocyanate can react with either Type I or Type II (or indeed with other oxidizing agents) to produce the semi-stable selenocyanogen (SCN)2. Finally, sodium nitrite may react with either Type I or Type II PSs to produce peroxynitrate (again, semi-stable) that can kill bacteria and nitrate tyrosine. Many of these salts (except azide) are non-toxic, and may be clinically applicable.
Reconstructing Bone with Natural Bone Graft: A Review of In Vivo Studies in Bone Defect Animal Model
Authors: Liu Mengying , Lv Yonggang
Published: December 2018

Bone defects caused by fracture, disease or congenital defect remains a medically important problem to be solved. Bone tissue engineering (BTE) is a promising approach by providing scaffolds to guide and support the treatment of bone defects. However, the autologous bone graft has many defects such as limited sources and long surgical procedures. Therefore, xenograft bone graft is considered as one of the best substitutions and has been effectively used in clinical practice. Due to better preserved natural bone structure, suitable mechanical properties, low immunogenicity, good osteoinductivity and osteoconductivity in natural bone graft, decellularized and demineralized bone matrix (DBM) scaffolds were selected and discussed in the present review. In vivo animal models provide a complex physiological environment for understanding and evaluating material properties and provide important reference data for clinical trials. The purpose of this review is to outline the in vivo bone regeneration and remodeling capabilities of decellularized and DBM scaffolds in bone defect models to better evaluate the potential of these two types of scaffolds in BTE. Taking into account the limitations of the state-of-the-art technology, the results of the animal bone defect model also provide important information for future design of natural bone composite scaffolds.
Colloidal Lignin Particles as Adhesives for Soft Materials
Authors: Mattinen Maija-Liisa , Riviere Guillaume , Henn Alexander , Nugroho Robertus Wahyu N. , Leskinen Timo , Nivala Outi , Valle-Delgado Juan José , Kostiainen Mauri A. , Österberg Monika
Published: December 2018

Lignin has interesting functionalities to be exploited in adhesives for medicine, foods and textiles. Nanoparticles (NPs) < 100 nm coated with poly (L-lysine), PL and poly(L-glutamic acid) PGA were prepared from the laccase treated lignin to coat nanocellulose fibrils (CNF) with heat. NPs ca. 300 nm were prepared, β-casein coated and cross-linked with transglutaminase (Tgase) to agglutinate chamois. Size exclusion chromatography (SEC) and Fourier-transform infrared (FTIR) spectroscopy were used to characterize polymerized lignin, while zeta potential and dynamic light scattering (DLS) to ensure coating of colloidal lignin particles (CLPs). Protein adsorption on lignin was studied by quartz crystal microbalance (QCM). Atomic force microscopy (AFM) was exploited to examine interactions between different polymers and to image NPs with transmission electron microscopy (TEM). Tensile testing showed, when using CLPs for the adhesion, the stress improved ca. 10 and strain ca. 6 times compared to unmodified Kraft. For the β-casein NPs, the values were 20 and 8, respectively, and for the β-casein coated CLPs between these two cases. When NPs were dispersed in adhesive formulation, the increased Young’s moduli confirmed significant improvement in the stiffness of the joints over the adhesive alone. Exploitation of lignin in nanoparticulate morphology is a potential method to prepare bionanomaterials for advanced applications.
Enhancing Output Power of Textured Silicon Solar Cells by Embedding Indium Plasmonic Nanoparticles in Layers within Antireflective Coating
Authors: Ho Wen-Jeng , Liu Jheng-Jie , Yang Yun-Chieh , Ho Chun-Hung
Published: December 2018

In this study, we sought to enhance the output power and conversion efficiency of textured silicon solar cells by layering two-dimensional indium nanoparticles (In NPs) within a double-layer (SiNx/SiO2) antireflective coating (ARC) to induce plasmonic forward scattering. The plasmonic effects were characterized using Raman scattering, absorbance spectra, optical reflectance, and external quantum efficiency. We compared the optical and electrical performance of cells with and without single layers and double layers of In NPs. The conversion efficiency of the cell with a double layer of In NPs (16.97%) was higher than that of the cell with a single layer of In NPs (16.61%) and greatly exceeded that of the cell without In NPs (16.16%). We also conducted a comprehensive study on the light-trapping performance of the textured silicon solar cells with and without layers of In NPs within the double layer of ARC at angles from 0° to 75°. The total electrical output power of cells under air mass (AM) 1.5 G illumination was calculated. The application of a double layer of In NPs enabled an impressive 53.42% improvement in electrical output power (compared to the cell without NPs) thanks to the effects of plasmonic forward scattering.
Porous Carrageenan-Derived Carbons for Efficient Ciprofloxacin Removal from Water
Authors: Nogueira João , António Maria , Mikhalev Sergey M. , Fateixa Sara , Trindade Tito , Daniel-da-Silva Ana L.
Published: December 2018

Porous carbon materials derived from biopolymers are attractive sorbents for the removal of emerging pollutants from water, due to their high specific surface area, high porosity, tunable surface chemistry, and reasonable cost. However, carrageenan biopolymers were scarcely investigated as a carbon source to prepare porous carbon materials. Herein, hydrochars (HCs) and porous activated carbons (ACs) derived from natural occurring polysaccharides with variable sulfate content (κ-, ι- and λ-carrageenan) were prepared and investigated in the uptake of ciprofloxacin, which is an antibiotic detected in water sources and that poses serious hazards to public health. The materials were prepared using hydrothermal carbonization and subsequent chemical activation with KOH to increase the available surface area. The activated carbons were markedly microporous, presenting high specific surface area, up to 2800 m2/g. Activated carbons derived from κ- and λ-carrageenan showed high adsorption capacity (422 and 459 mg/g, respectively) for ciprofloxacin and fast adsorption kinetics, reaching the sorption equilibrium in approximately 5 min. These features place the ACs investigated here among the best systems reported in the literature for the removal of ciprofloxacin from water.
Exploring Protein-Inorganic Hybrid Nanoflowers and Immune Magnetic Nanobeads to Detect Salmonella Typhimurium
Authors: Wang Lei , Huo Xiaoting , Guo Ruya , Zhang Qiang , Lin Jianhan
Published: December 2018

Early screening of pathogenic bacteria is key to preventing and controlling outbreaks of foodborne diseases. In this study, protein-inorganic hybrid nanoflowers were synthesized for signal amplification and used with a calcium ion selective electrode (Ca-ISE) to establish a new enzyme-free assay for rapid and sensitive detection of Salmonella. Calcium hydrophosphate crystals were first conjugated with polyclonal antibodies against Salmonella to synthesize immune calcium nanoflowers (CaNFs), and streptavidin modified magnetic nanobeads (MNBs) were conjugated with biotinylated monoclonal antibodies against Salmonella to form immune MNBs. After target bacteria were separated using immune MNBs to form magnetic bacteria, immune CaNFs were conjugated with magnetic bacteria to form nanoflower conjugated bacteria. Then, hydrogen chloride was used to release calcium ions from nanoflower conjugated bacteria. After magnetic separation, the supernatant was finally injected as a continuous-flow to fluidic chip with Ca-ISE for specific detection of calcium ions. The supernatant’s potential had a good linear relationship with bacteria concentration, and this assay was able to detect the S. Typhimurium cells as low as 28 colony forming units/mL within two hours. The mean recovery of target bacteria in spiked chicken samples was 95.0%. This proposed assay shows the potential for rapid, sensitive, and on-line detection of foodborne pathogens.
Dietary Inflammatory Index and Disability-Free Survival in Community-Dwelling Older Adults
Authors: Tomata Yasutake , Shivappa Nitin , Zhang Shu , Nurrika Dieta , Tanji Fumiya , Sugawara Yumi , Hébert James , Tsuji Ichiro
Published: December 2018

Background: Previous studies have reported that a higher dietary inflammatory index (DII®) score is related to a higher risk of mortality and conditions that result in functional disability, such as cardiovascular disease, dementia, and fractures. Although these findings suggest that higher DII scores would affect disability-free survival, this has never been investigated directly. The present study investigated the association between the DII score and disability-free survival. Methods: We analyzed follow-up data covering a 12-year period for 793 older adults (≥70 years) participating in a Japanese community-based cohort study. DII scores were computed on the basis of dietary intake and assessed using the Brief Self-Administered Diet History Questionnaire. Data on incident functional disability were retrieved from the public Long-Term Care Insurance database. We applied the Cox model for estimating the adjusted hazard ratios (HRs) of the composite outcome (incident functional disability or death) according to DII score tertiles (T1–T3). Results: The proportion of men was 47.3%; mean (SD) age was 75.2 (4.5) years. The 12-year incidence of the composite outcome was 65.5%. A higher DII score was related to a higher risk for the composite outcome: HRs (95% confidence interval) were 1.05 (0.84, 1.32) for T2 and 1.26 (1.01, 1.57) for T3 (p-trend = 0.040) compared to the most anti-inflammatory T1 reference (HR = 1.00). Conclusions: These results suggest that a pro-inflammatory diet might be a modifiable factor affecting disability-free survival in the older population. Additional prospective studies are needed to confirm this relationship.
Disordered Eating Attitudes and Behavioral and Neuroelectric Indices of Cognitive Flexibility in Individuals with Overweight and Obesity
Authors: Edwards Caitlyn G. , Walk Anne M. , Thompson Sharon V. , Mullen Sean P. , Holscher Hannah D. , Khan Naiman A.
Published: December 2018

Impairment in cognitive flexibility is a trait characteristic among individuals with diagnosed eating disorders. However, the extent to which these relationships exist in individuals with overweight or obesity remains unclear. Furthermore, there is a lack of knowledge characterizing the neural underpinnings of these relationships. The current study aimed to investigate disordered eating attitudes and cognitive flexibility among adults with overweight and obesity. The Eating Attitudes Test (EAT-26) and a task-switching paradigm were collected from 132 adults (50 males, Body Mass Index (BMI) = 32.0 ± 5.8 kg/m2). Behavioral measures (accuracy and reaction time (RT)) and neuroelectric indices (amplitude and latency) of the P3 component were assessed. Hierarchical linear regressions, following adjustment of age, sex, intelligence quotient (IQ), weight status, and diet quality were developed using summative and subscale scores of the EAT-26. Higher EAT-26 summative scores, and the Dieting subscale, were related to longer RT. Only the Bulimia and Food Preoccupation subscale was related to longer P3 latency. The relationship between disordered eating attitudes and cognitive flexibility extends to individuals with overweight and obesity and is independent of age, sex, IQ, weight status, and diet quality. These findings are important, as differences in cognitive flexibility can lead to behavioral rigidity. Future work should aim to examine other neuroelectric components to identify where differences driving behavioral latencies may be occurring.