bluuebunny/crossref_metadata_2025 huggingface dataset:
Pro-Inflammatory Serum Amyloid a Stimulates Renal Dysfunction and Enhances Atherosclerosis in Apo E-Deficient Mice
Authors: Gao Antony , Gupta Sameesh , Shi Han , Liu Yuyang , Schroder Angie L. , Witting Paul K. , Ahmad Gulfam
Published: November 2021

Acute serum amyloid A (SAA) is an apolipoprotein that mediates pro-inflammatory and pro-atherogenic pathways. SAA-mediated signalling is diverse and includes canonical and acute immunoregulatory pathways in a range of cell types and organs. This study aimed to further elucidate the roles for SAA in the pathogenesis of vascular and renal dysfunction. Two groups of male ApoE-deficient mice were administered SAA (100 µL, 120 µg/mL) or vehicle control (100 µL PBS) and monitored for 4 or 16 weeks after SAA treatment; tissue was harvested for biochemical and histological analyses at each time point. Under these conditions, SAA administration induced crosstalk between NF-κB and Nrf2 transcriptional factors, leading to downstream induction of pro-inflammatory mediators and antioxidant response elements 4 weeks after SAA administration, respectively. SAA treatment stimulated an upregulation of renal IFN-γ with a concomitant increase in renal levels of p38 MAPK and matrix metalloproteinase (MMP) activities, which is linked to tissue fibrosis. In the kidney of SAA-treated mice, the immunolocalisation of inducible nitric oxide synthase (iNOS) was markedly increased, and this was localised to the parietal epithelial cells lining Bowman’s space within glomeruli, which led to progressive renal fibrosis. Assessment of aortic root lesion at the study endpoint revealed accelerated atherosclerosis formation; animals treated with SAA also showed evidence of a thinned fibrous cap as judged by diffuse collagen staining. Together, this suggests that SAA elicits early renal dysfunction through promoting the IFN-γ-iNOS-p38 MAPK axis that manifests as the fibrosis of renal tissue and enhanced cardiovascular disease.
Mutation in OsFWL7 Affects Cadmium and Micronutrient Metal Accumulation in Rice
Authors: Gao Qingsong , Liu Lei , Zhou Haiying , Liu Xi , Li Wei , Min Yu , Yan Yurong , Ji Jianhui , Zhang Hao , Zhao Xiangxiang
Published: November 2021

Micronutrient metals, such as Mn, Cu, Fe, and Zn, are essential heavy metals for plant growth and development, while Cd is a nonessential heavy metal that is highly toxic to both plants and humans. Our understanding of the molecular mechanisms underlying Cd and micronutrient metal accumulation in plants remains incomplete. Here, we show that OsFWL7, an FW2.2-like (FWL) family gene in Oryza sativa, is preferentially expressed in the root and encodes a protein localized to the cell membrane. The osfwl7 mutation reduces both the uptake and the root-to-shoot translocation of Cd in rice plants. Additionally, the accumulation of micronutrient metals, including Mn, Cu, and Fe, was lower in osfwl7 mutants than in the wildtype plants under normal growth conditions. Moreover, the osfwl7 mutation affects the expression of several heavy metal transporter genes. Protein interaction analyses reveal that rice FWL proteins interact with themselves and one another, and with several membrane microdomain marker proteins. Our results suggest that OsFWL7 is involved in Cd and micronutrient metal accumulation in rice. Additionally, rice FWL proteins may form oligomers and some of them may be located in membrane microdomains.
Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute β-Adrenergic Receptor Stimulation In Vivo
Authors: Güran Alican , Ji Yanlong , Fang Pan , Pan Kuan-Ting , Urlaub Henning , Avkiran Metin , Lenz Christof
Published: November 2021

β-adrenergic receptor (β-AR) stimulation represents a major mechanism of modulating cardiac output. In spite of its fundamental importance, its molecular basis on the level of cell signalling has not been characterised in detail yet. We employed mass spectrometry-based proteome and phosphoproteome analysis using SuperSILAC (spike-in stable isotope labelling by amino acids in cell culture) standardization to generate a comprehensive map of acute phosphoproteome changes in mice upon administration of isoprenaline (ISO), a synthetic β-AR agonist that targets both β1-AR and β2-AR subtypes. Our data describe 8597 quantitated phosphopeptides corresponding to 10,164 known and novel phospho-events from 2975 proteins. In total, 197 of these phospho-events showed significantly altered phosphorylation, indicating an intricate signalling network activated in response to β-AR stimulation. In addition, we unexpectedly detected significant cardiac expression and ISO-induced fragmentation of junctophilin-1, a junctophilin isoform hitherto only thought to be expressed in skeletal muscle. Data are available via ProteomeXchange with identifier PXD025569.
PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective Peptides
Authors: Ugalde-Triviño Lola , Díaz-Guerra Margarita
Published: November 2021

Therapies for stroke have remained elusive in the past despite the great relevance of this pathology. However, recent results have provided strong evidence that postsynaptic density protein-95 (PSD-95) can be exploited as an efficient target for stroke neuroprotection by strategies able to counteract excitotoxicity, a major mechanism of neuronal death after ischemic stroke. This scaffold protein is key to the maintenance of a complex framework of protein interactions established at the postsynaptic density (PSD) of excitatory neurons, relevant to neuronal function and survival. Using cell penetrating peptides (CPPs) as therapeutic tools, two different approaches have been devised and advanced to different levels of clinical development. First, nerinetide (Phase 3) and AVLX-144 (Phase 1) were designed to interfere with the coupling of the ternary complex formed by PSD-95 with GluN2B subunits of the N-methyl-D-aspartate type of glutamate receptors (NMDARs) and neuronal nitric oxide synthase (nNOS). These peptides reduced neurotoxicity derived from NMDAR overactivation, decreased infarct volume and improved neurobehavioral results in different models of ischemic stroke. However, an important caveat to this approach was PSD-95 processing by calpain, a pathological mechanism specifically induced by excitotoxicity that results in a profound alteration of survival signaling. Thus, a third peptide (TP95414) has been recently developed to interfere with PSD-95 cleavage and reduce neuronal death, which also improves neurological outcome in a preclinical mouse model of permanent ischemia. Here, we review recent advancements in the development and characterization of PSD-95-targeted CPPs and propose the combination of these two approaches to improve treatment of stroke and other excitotoxicity-associated disorders.
Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?
Authors: De Martino Viviana , Rossi Michela , Battafarano Giulia , Pepe Jessica , Minisola Salvatore , Del Fattore Andrea
Published: November 2021

Osteosarcoma (OS) is a skeletal tumor affecting mainly children and adolescents. The presence of distance metastasis is frequent and it is localized preferentially to the lung, representing the main reason for death among patients. The therapeutic approaches are based on surgery and chemotherapeutics. However, the drug resistance and the side effects associated with the chemotherapy require the identification of new therapeutic approaches. The understanding of the complex biological scenario of the osteosarcoma will open the way for the identification of new targets for its treatment. Recently, a great interest of scientific community is for extracellular vesicles (EVs), that are released in the tumor microenvironment and are important regulators of tumor proliferation and the metastatic process. At the same time, circulating extracellular vesicles can be exploited as diagnostic and prognostic biomarkers, and they can be loaded with drugs as a new therapeutic approach for osteosarcoma patients. Thus, the characterization of OS-related EVs could represent a way to convert these vesicles from antagonists for human health into therapeutic and/or diagnostic agents.
Genome-Wide Analysis of MYB10 Transcription Factor in Fragaria and Identification of QTLs Associated with Fruit Color in Octoploid Strawberry
Authors: Manivannan Abinaya , Han Koeun , Lee Sun Yi , Lee Hye-Eun , Hong Jong Pil , Kim Jinhee , Lee Ye-Rin , Lee Eun Su , Kim Do-Sun
Published: November 2021

The genus Fragaria encompass fruits with diverse colors influenced by the distribution and accumulation of anthocyanin. Particularly, the fruit colors of strawberries with different ploidy levels are determined by expression and natural variations in the vital structural and regulatory genes involved in the anthocyanin pathway. Among the regulatory genes, MYB10 transcription factor is crucial for the expression of structural genes in the anthocyanin pathway. In the present study, we performed a genome wide investigation of MYB10 in the diploid and octoploid Fragaria species. Further, we identified seven quantitative trait loci (QTLs) associated with fruit color in octoploid strawberry. In addition, we predicted 20 candidate genes primarily influencing the fruit color based on the QTL results and transcriptome analysis of fruit skin and flesh tissues of light pink, red, and dark red strawberries. Moreover, the computational and transcriptome analysis of MYB10 in octoploid strawberry suggests that the difference in fruit colors could be predominantly influenced by the expression of MYB10 from the F. iinumae subgenome. The outcomes of the present endeavor will provide a platform for the understanding and tailoring of anthocyanin pathway in strawberry for the production of fruits with aesthetic colors.
Calcite Nanotuned Chitinous Skeletons of Giant Ianthella basta Marine Demosponge
Authors: Kertmen Ahmet , Petrenko Iaroslav , Schimpf Christian , Rafaja David , Petrova Olga , Sivkov Viktor , Nekipelov Sergey , Fursov Andriy , Stelling Allison L. , Heimler Korbinian , Rogoll Anika , Vogt Carla , Ehrlich Hermann
Published: November 2021

Marine sponges were among the first multicellular organisms on our planet and have survived to this day thanks to their unique mechanisms of chemical defense and the specific design of their skeletons, which have been optimized over millions of years of evolution to effectively inhabit the aquatic environment. In this work, we carried out studies to elucidate the nature and nanostructural organization of three-dimensional skeletal microfibers of the giant marine demosponge Ianthella basta, the body of which is a micro-reticular, durable structure that determines the ideal filtration function of this organism. For the first time, using the battery of analytical tools including three-dimensional micro—X-ray Fluorescence (3D-µXRF), X-ray diffraction (XRD), infra-red (FTIR), Raman and Near Edge X-ray Fine Structure (NEXAFS) spectroscopy, we have shown that biomineral calcite is responsible for nano-tuning the skeletal fibers of this sponge species. This is the first report on the presence of a calcitic mineral phase in representatives of verongiid sponges which belong to the class Demospongiae. Our experimental data suggest a possible role for structural amino polysaccharide chitin as a template for calcification. Our study suggests further experiments to elucidate both the origin of calcium carbonate inside the skeleton of this sponge and the mechanisms of biomineralization in the surface layers of chitin microfibers saturated with bromotyrosines, which have effective antimicrobial properties and are responsible for the chemical defense of this organism. The discovery of the calcified phase in the chitinous template of I. basta skeleton is expected to broaden the knowledge in biomineralization science where the calcium carbonate is regarded as a valuable material for applications in biomedicine, environmental science, and even in civil engineering.
Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes
Authors: Baral Ananda , Park Pil-Hoon
Published: November 2021

Leptin, a hormone that is predominantly produced by adipose tissue, is closely associated with various liver diseases. However, there is a lack of understanding as to whether leptin directly induces cytotoxic effects in hepatocytes as well as the mechanisms that are involved. Inflammasomes, which are critical components in the innate immune system, have been recently shown to modulate cell death. In this study, we examined the effect of leptin on the viability of rat hepatocytes and the underlying mechanisms, with a particular focus on the role of inflammasomes activation. Leptin treatment induced cytotoxicity in rat hepatocytes, as determined by decreased cell viability, increased caspase-3 activity, and the enhanced release of lactate dehydrogenase. NLRP3 inflammasomes were activated by leptin both in vitro and in vivo, as determined by the maturation of interleukin-1β and caspase-1, and the increased expression of inflammasome components, including NLRP3 and ASC. Mechanistically, leptin-induced inflammasome activation is mediated via the axis of ROS production, ER stress, and autophagy. Notably, the inhibition of inflammasomes by treatment with the NLRP3 inhibitor or the IL-1 receptor antagonist protected the hepatocytes from leptin-induced cell death. Together, these results indicate that leptin exerts cytotoxic effects in hepatocytes, at least in part, via the activation of NLRP3 inflammasomes.
Study of structures of tillage working bodies with overhead chisel
Authors: Kazubov A. A. , Mironov D. A.
Published: November 2021

Agriculture is the most important branch of the national economy, providing the population of our country with food and obtaining raw materials for a number of industries. The role of agriculture in the economy of Russia and its regions shows the structure and level of development of the state. It is impossible to get a good harvest without proper cultivation of the land. Cultivation of any crops begins with basic tillage, which is one of the most time-consuming operations. For this purpose, mounted and semi-mounted ploughshares are used. One of the effective ways to reduce the energy intensity of the main tillage process is chisel-shaped ploughshares with a protruding toe (chisel), which is located below the blade by 20 … 25 mm. Due to this, the sinking capacity of the hull and its resource are improved. To achieve this goal, such methods are used as the influx of metal in the field-cut zone, which increases its thickness, the surfacing of the nose part, which increases wear resistance and, accordingly, reduces wear of the sock in thickness, welding to the sock with a plate made of a more high-strength material [1].
Right-sided acute diverticulitis in the West: experience at a university hospital in Argentina
Authors: Palacios Huatuco René M. , Pantoja Pachajoa Diana A. , Liaño Julian E. , Picón Molina Héctor A. , Palencia Rafael , Doniquian Alejandro M. , Parodi Matías
Published: November 2021

Purpose: In the West, diverticular disease is located mainly in the left colon. However, it can also present in the right colon, with an incidence of 1% to 2% in Caucasians. The purpose of this study was to describe our experience in right-sided acute diverticulitis (RD).Methods: In this retrospective study, 410 patients with acute diverticulitis treated from 2013 to 2020 were included in a university hospital in Córdoba, Argentina. Colonic diverticulitis was stratified into 2 groups; RD and left-sided acute diverticulitis. Demographic and clinical variables, laboratory and imaging findings, type of treatment, follow-up, and recurrence were analyzed.Results: Sixteen patients (3.9%) with RD were identified; 62.5% were male and the mean age was 40.7±11.7 years. A total of 81.3% were Caucasian and 18.7% Native American. Significant differences were found between both groups of diverticulitis; patients with RD were younger (P=0.001), with lower BMI (P=0.01), comorbidity rate (P=0.01), Charlson comorbidity index (P=0.02), hospital stay (P=0.01), severity according to the Hinchey classification (P=0.001) and had a lower recurrence rate (P=0.001). There were no significant differences in sex (P=0.95), duration of pain until admission (P=0.05), laboratory findings (P=0.23) and treatment (P=0.34).Conclusion: Conservative treatment predominated in RD, with a lower rate of complications and recurrences, providing data that support conservative therapy as initial treatment in RD in our environment.
Medication prescribing in face-to-face versus telehealth consultations during the COVID-19 pandemic in Australian general practice: a retrospective observational study
Authors: Wabe Nasir , Thomas Judith , Sezgin Gorkem , Sheikh Muhammad Kashif , Gault Emma , Georgiou Andrew
Published: November 2021

Background

There has been a precipitous rise in telehealth use in general practice during the COVID-19 pandemic. Understanding differences between face-to-face and telehealth consulting is an important component for planning the future use of telehealth services beyond the pandemic. However, there is limited evidence on whether telehealth consulting impacts medication prescribing under pandemic circumstances.

Aim

To compare medication prescribing in face-to-face consultations with telehealth during the COVID-19 pandemic in Australian general practice.

Design & setting

A multisite, retrospective observational study. De-identified routinely collected electronic health data were used, which were extracted from 806 general practices in Victoria and New South Wales (NSW), Australia, between April and December 2020.

Method

The primary outcome measure was whether at least one medication was prescribed following a telehealth or face-to-face consultation. Data were reported by medication and for each of the Anatomical Therapeutic Chemical (ATC) classification system level 1 groups. The secondary outcome measure was first-time prescribing. Telehealth included both telephone and video consultations.

Results

A total of 13 608 216 consultations satisfied the inclusion criteria (61.0% face to face and 39.0% telehealth). Most telehealth consultations were conducted via telephone (97.8%). Overall, 39.3% of face-to-face and 33.0% of telehealth consultations prescribed at least one medication, which is a statistically significant difference (adjusted odds ratio [OR] 1.38, 95% confidence interval [CI] = 1.379 to 1.381). The prescribing rate was greater for face-to-face versus telehealth consultations for all drug groups except ATC level 1N (nervous system).

Conclusion

Under COVID-19 restrictions in the states of Victoria and NSW, Australia, medication prescribing was higher in face-to-face consultations when compared with telehealth consultations in the study population.
GP perceptions of telehealth services in Australia: a qualitative study
Authors: De Guzman Keshia R , Snoswell Centaine L , Giles Chantelle M , Smith Anthony C , Haydon Helen M
Published: November 2021

Background

Primary care providers have been rapidly transitioning from in-person to telehealth care during the 2019 coronavirus (COVID-19) pandemic. There is an opportunity for new research in a rapidly evolving area, where evidence for telehealth services in primary care in the Australian setting remains limited.

Aim

To explore general practitioner (GP) perceptions on providing telehealth (telephone and video consultation) services in primary care in Australia.

Design & setting

A qualitative study using semi-structured interviews to gain an understanding of GP perceptions on telehealth use in Australia.

Method

GPs across Australia were purposively sampled. Semi-structured interviews were conducted, recorded, and transcribed verbatim for analysis. Transcripts were analysed using inductive thematic analysis to identify initial codes, which were then organised into themes.

Results

Fourteen GPs were interviewed. Two major themes that described GP perceptions of telehealth were: (1) existence of business and financial pressures in general practice; and (2) providing quality of care in Australia. These two themes interacted with four minor themes:(3) consumer-led care; (4) COVID-19 as a driver for telehealth reimbursement and adoption; (5) refining logistical processes; and (6) GP experiences shape telehealth use.

Conclusion

This study found that multiple considerations influenced GP choice of in-person, videoconference, or telephone consultation mode. For telehealth to be used routinely within primary care settings, evidence that supports the delivery of higher quality care to patients through telehealth and sustainable funding models will be required.
Primary Liver Cancer in Golestan Province, Northeastern Iran: 13-Year Experience of Golestan Population-Based Cancer Registry (GPCR)
Authors: Amlashi Fazel Isapanah , Ashkbari Ali , Amiriani Taghi , Norouzi Alireza , Poorkhani Amir Houshang , Sedaghat SeyedMehdi , Livani Somayeh , Ashaari Mohammad , Sadeghzadeh Hamideh , Besharat Sima , Semnani Shahryar , Roshamdel Gholamreza
Published: November 2021

Background: Liver cancer (LC) is among the most common and fatal cancers worldwide. A four-fold increasing trend is reported for LC age-standardized mortality rate (ASMR) in Iran within 1990–2015. In the present study, we aimed to report the incidence rate of LC during the 13-year establishment of the Golestan population-based cancer registry (GPCR). Methods: Age-standardized incidence rate (ASIR) per 100000 person-years was calculated using CanReg5 software. The Joint point regression analysis was used to assess the temporal trends in incidence rate of LC. Results: During the study period, GPCR registered 575 of LC cases, of which 373 (64.9%) were men and 297 (51.6%) lived in rural areas. The mean (SD) age of LC in men and women were 60.3 (17.2) and 58.0 (17.1), respectively. The ASIR of LC was significantly higher in men than women (4.7 vs. 2.6; P value<0.01) and a minimal increasing trend in LC incidence was observed in both sexes. The incidence rate of LC was significantly higher in rural areas compared to the urbans (3.91 vs. 3.40; P value=0.04). In the last 13 years, rural population had a significant increasing trend in ASIR of LC (average annual percent change [AAPC]=7.85, P value=0.005). Conclusion: LC was more prevalent in men among both urban and rural populations. The results showed a significant increasing trend in rural areas that requires Golestan health care system to take action in controlling the burden of LC in rural areas.
Description of Epidemiological Features, Symptoms and Mortality of the Patients with COVID–19 in Some Provinces of Iran
Authors: Khosravi Shadmani Fatemeh , Amanollahi Alireza , Zali Alireza , Najafi Farid , Karami Manoochehr , Moradi Ghobad , Mohammadian-Hafshejani Abdollah , Ahmadi Ali , Sartipi Majid , Shojaeian Masoud , Noori Elham , Javaheri Masoumeh , Bahadorimonfared Ayad , Hashemi-Nazari Seyed-Saeed
Published: November 2021

Background: Clinical manifestations of COVID–19 are different. There are some risk factors for COVID–19. This study aimed to describe the epidemiological features, symptoms and mortality of the patients with COVID–19 in Iran. Methods: This were a cohort study performed on 103,179 patients with COVID–19. The demographic and clinical data were collected in selected provinces. The required data of all patients was extracted from the COVID registry system and analyzed using STATA version 14 and Excel 2016. Results: The mean age was 52.40 years for men and 52.41 years for women. About 55.2% of the study population were male and 44.8% were female. Totally, 60.9% (5085) of deaths happened in men and 39.1% (3263) in women. The mean time from onset of symptoms to hospitalization in men and women were 3.47 and 3.48 days, respectively. The mean time from onset of symptoms to isolation was 2.81 days in men and was 2.87 days in women, from onset of symptoms to death was 9.29 and 9.54 days, respectively, from onset of symptoms to discharge was 7.47 and 7.39 days, and from hospitalization to death was 6.76 and 7.05 days. Cough and shortness of breath were the most common symptoms in the patients. Conclusion: According to the results, the overall mortality rate was higher in men than women. Women with cardiovascular disease and diabetes were more likely to die. The mean time from onset of symptoms to hospitalization, isolation, and discharge was similar in men and women.
Release of Civil Registry Causes of Death Data in Iran (2015 to 2019) - Expectations and Doubts!
Authors: Tadbiri Hooman , Moradi-Lakeh Maziar , Naghavi Mohsen
Published: November 2021

Background: The National Organization for Civil Registration (NOCR) of Iran has reported causes of death data by ICD-10 chapters for the first time in 2020. Methods: We used this report to review the share of ICD chapters among all deaths in each province and compare them with the Global Burden of Disease (GBD) study. Results: There are major changes in the distribution of causes of death between 2017 and 2018, especially in D50-D89 (Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism) from 0.76% to 38.94%, and I00-I99 (Diseases of the circulatory system) from 39.27% to 7.09%. Such dramatic changes are probably the results of changes in coding practices or definitions or issues in analysis. Conclusion: Causes of death reports should be timely, clear, and robust on methods. They should contain a minimum level of details, at least 3-digit ICD codes to be useful for public health and medical professionals.
Kindsmisshandlung – Kinderschutz
Authors: Lips Ulrich , Wopmann Markus
Published: November 2021

Kindsmisshandlung ist häufig. Das ist auch ohne Statistiken klar, die einerseits aus Gründen von Dunkelziffer, Falldefinition usw. fehlen oder ungenau sind und anderseits, weil Kindsmisshandlung von Institutionen und Personen aus verschiedenen Fachgebieten (Medizin, Sozialarbeit, Pädagogik, aber auch Behörden) festgestellt wird, deren Erfassungen nicht kompatibel sind.
Brückenschlag zwischen Pädiatrie und Public Health:
Authors: Huber-Gieseke Tina , Stronski Susanne
Published: November 2021

Ein Blick auf die Geschichte der Schulärztinnen und Schulärzte (SÄ) zeigt, dass ihre Arbeit seit jeher eng mit den jeweiligen Lebensbedingungen und der gesundheitlichen Situation der Kinder, Jugendlichen, ihrer Familien und ihrem Umfeld verbunden sind. Die SÄ vernetzten sich mit Einrichtungen, in denen sich Kinder und Jugendliche aufhielten, die sich um das Kind kümmerten und sie hielten Kontakt zu Randgruppen. Der Fokus bestand darin, diejenigen aufzufangen, die zwischen die Maschen des Systems gefallen waren. Der Zugang zur Gesundheitsversorgung und Prävention sollte für alle möglich sein, unabhängig vom sozialen Status, durch einen niederschwelligem, wo nötig aktiven Ansatz.
Pengaruh Jumlah Taksiran Dan Uang Pinjaman Terhadap Laba Bersih Pada Rahn Di PT BPRS Harum Hikmahnugraha Garut
Authors: Rosdiana Anisa , Huda Badriyatul , Muslim Buchori
Published: November 2021

ABSTRAKBerdasarkan Hasil Penelitian diawal Bahwa yang menelatar belakangi penelitian ini adalah fluktuatifnya Jumlah taksiran dan uang pinjaman di PT BPRS Harum Hikmahnugraha dan tidak menentunya harga emas dipasaran dan sering terjadi kesalahan dalam menaksir barang jaminan khususnya emas. Penelitian ini Bertujuan untuk mengetahui begaimana pengaruh Jumlah taksiran terhadap laba bersih , mengetahui pengaruh uang pinjaman terhadap laba bersih di PT BPRS Harum Hikmahnugraha. Objek Penelitian pada laporan ini adalah untuk mengukur Laba bersih di PT BPRS Harum Hikmahnugraha, adapun jenis penelitiannya adalah kuantitatif asosiatif, jenis datanya adalah data primer, dan menggunakan teknik pengumpulan data berupa dokumentasi dan studi pustaka.Sedangkan teknik pengambilan sampelnya adalah non probability sampling , dengan populasi seluruh laporan keuangan triwulan BPRS Harum Hikmahnugraha periode 2016-2020. Hasil penelitian ini menunjukan Bahwa tidak terdapat pengaruh antara jumlah taksiran terhadap laba bersih di BPRS Harum Hikmahnugraha dengan hasil uji t dimana nilai Thitung <Ttabel  (1.352 < 2,109), terdapat pengaruh  yang signifikan antara Uang pinjaman terhadap laba bersih di BPRS Harum Hikmahnugraha dari hasil Uji t dimana Thitung > Ttabel (2,401 > 1,987), dan secara simultan terdapat pengaruh yang signifikan antara Jumlah taksiran dan uang pinjaman terhadap laba bersih di PT BPRS Harum Hikahnugraha dengan hasil Uji f dimana nilai Fhitung > Ftabel (2,843  > 2,052 ).ABSTRACKBased on the results of the study at the beginning that the background of this research is the fluctuations in the amount of estimates and loan money at PT BPRS Harum Hikmahnugraha and uncertain gold prices in the market and frequent errors in estimating collateral items, especially gold. This study aims to determine how the influence of the estimated amount of net income, determine the effect of loan money on net income in PT BPRS Harum Hikmahnugraha. The object of research in this report is to measure net income at PT BPRS Harum Hikmahnugraha, while the type of research is associative quantitative, the type of data is primary data, and uses data collection techniques in the form of documentation and literature studies. While the sampling technique is non probability sampling, with population of all BPRS Harum Hikmahnugraha quarterly financial statements for the 2016-2020 period. The results of this study indicate that there is no leverage between the estimated amount of net income in the BPRS Harum Hikmahnugraha with the results of t test where the value of  t account < t table (1,352 <2,109), there is a significant influence between the loan money to the net profit at Harum Hikmahnugraha from the Test Results t where t account>t table (2.401> 1.987), and simultaneously there is a significant influence between the amount of estimated and borrowed money on net income in PT BPRS Harum Hikahnugraha with Test results f where the value of Fcount> Ftable (2.843> 2.052).
A review of the participation of smallholder farmers in land-based carbon payment schemes
Authors:   TMG Research gGmbH, Tamba Yvonne , Wafula Joseph , Magaju Christine , Aynekulu Ermias , Winowiecki Leigh , St-Jacques Bruno , Stiem-Bhatia Larissa , Arias-Navarro Cristina ,   World Agroforestry (ICRAF)
Published: November 2021

This paper highlights approaches for smallholder engagement, identifies key barriers to participation, and outlines options to enhance farmers’ agency.
Simulation of the Pollutants’ Transfer along the Selenga River on the Territories of Mongolia and Russia
Authors:   Zomonova E.M., Gomboyev B.O., Zandakova A.B.
Published: November 2021

Simulation of the pollutants, transfer in the Selenga River basin and the transboundary transfer from the territory of Mongolia share in the total input of pollutants into the Baikal lake have been presented. The calculations have shown that the volume of many pollutants supplied to the Baikal with the Selenga flow from the Mongolian territory does not exceed 30%. The main part of the pollutants volume is forming on the Russian territory (Republic of Buryatia and Transbaikal Kray)
Central Sites and the Development of Rural Settlements from the Middle to Late La Tène Period in Central Moravia
Authors: Čižmář Ivan , Danielisová Alžběta
Published: November 2021

At a certain point in time, there were two central places in central Moravia: an older unfortified central agglomeration near the present-day village of Němčice nad Hanou and a younger oppidum at Staré Hradisko. Each of this centres had its own approach to raw materials, orientation of the socio-economic contacts, and possibly political focus as well. Němčice, being located at one of the main branches of the Amber Road, connected the Middle Danube area from the Mediterranean to the Adriatic; Staré Hradisko eventually expanded these contacts into a systematic trade network, being under the strong influence of the Bohemian region with links to Bavaria. During the LT C2, in addition to the location of the central place, changes took place in terms of material culture and settlement strategies in the region. This was further accentuated in LT D1 by the shift of settlements towards the west, to the vicinity of the oppidum and, at the same time, vacation of the corridor around the Morava River. In an attempt to chronologically assess the settlement pattern, it became evident how important it is to define, as precisely as possible, the dating of individual sites. This was only possible thanks to the detailed and extensive study of the material available (Čižmář 2018). Thanks to precise dating of settlements and classification based on the new chronology, the seemingly illogical group of settlements in central Moravia revealed a distinct settlement network which, in particular during the period contemporary with the oppidum, allows us to see the significant changes in the number of sites and in the orientation of long-distance contacts that were possibly associated with historical events.
Pengembangan Wisata Berbasis Masyarakat untuk Meningkatkan Perekonomian Masyarakat Desa Sekapuk Kecamatan Ujung Pangkah Kabupaten Gresik
Authors: Al Ahsani Nasirudin , Fitrotul Kharisma , Fauziyah Ana , Nahdiya Berliantin
Published: November 2021

The water quality of the rivers in Gresik, specifically in Bengawan Solo river in Bungah-Ujung Pangkah area and the downstream of Brantas River in the Wringinanom-Driyorejo Region, is polluted as perceived from the total dissolved solids that reaches 5000 ppm. Meanwhile, the river water contaminated with microplastics in Bengawan Solo reaches 55.2/100 L and the downstream of Brantas River reaches 18.5/100 L3. The garbage does not only accumulate in rivers, but also on land. In Sekapuk Village, Ujung Pangkah Subdistrict, Gresik, there is a former limestone mine. Since the mining was completed, it ended up being a landfill from 2003 through 2017. The current study employs a qualitative research method. The data were collected from interviews, observation, and documentation. The objectives of this study are: 1) To determine the components of tourism and participatory planning in Setigi tourist attraction, 2) To determine the community development and empowerment in Setigi tourist attraction, and 3) to determine the supporting and inhibiting factors in managing Setigi tourist attraction. The results of this study are as follows: 1) Setigi tourist attraction's components include parking areas, toilets, prayer rooms, gazebos, photo spots, culinary areas, ATV cars, and others. The planning of this tourist attraction came from an idea of the village head to make the village into a tourist attraction. As a result, a regular meeting is held on the 1st of every month which is attended by members of BUMDES, PEMDES, other village institutions such as local community units (RT & RW) and other community members, 2) The community development is carried out by providing opportunities to establish stalls for women in family welfare program (PKK) groups and each local community unit (RT /RW) in Sekapuk Village, 3) The supporting factors are the ability and the willingness to establish Setigi tourist attraction. Meanwhile, the inhibiting factor is the limited funds in the tourist attraction development, but a joint saving program was planned by the village head.
Komunikasi Sosial Capital Sebagai Dakwah Kultural pada Masyarakat Islam di Pelosok Desa
Authors: Wira Supriyo
Published: November 2021

Indonesia needs to have social capital so that groups living in a society consisting of approximately 500 ethnic groups can unite. Every ethnicity has the potential to maintain its culture and territory. Moreover, Indonesia is a country where most of the population lives in rural areas and only a small part lives in urban areas. With the lack of economic development and education in the rural villages, the information flowing in the villages is not as fast and significant as in the cities. Even the da'i (preachers) have to fight harder to gain trust, so that they can provide precise and accurate religious information to the village community. This study discusses deeper on how Social Capital communication as a cultural da'wah can touch the community, especially in rural areas, to absorb religious information properly and correctly. This case study employs literature review method in collecting the data. The descriptive approach employed in this study also helps investigate the status of the existing factors and then looks at the relationship between one factor and another. Human resources or human capital is a very important and strategic capital in the life of a community organization. This is especially in terms of how a preacher as a communicator can convey his da'wah message to the village community, with a cultural and belief approach. Such way of communication is what makes the village communities easier to accept the da'wah activities since they are based on trust, mutual understanding and shared values. In addition, the communicators also convey all information about religion according to the existing culture and beliefs.
Improvement of monodispersity and shape symmetry of silica shell for PbS quantum dots by introducing surface silanization and adjusting reverse micelle size
Authors: Mukai Kohki , Ikeda Kosuke , Hatta Reo
Published: November 2021

Semiconductor quantum dots (QDs) are one of the promising constituent materials of quantum information processing devices. The technique of silica coating of colloidal QDs using the reverse micelle method has been realized for improving position controllability, but the problem is that monodispersity and shape symmetry deteriorate when increasing the coating thickness. In this paper, we report three effective ways to achieve large silica-coated QDs with solving this problem, i.e. proper silanization on the QD surface, control of reverse micelle size by adjusting the amount of QD solvent, and two-step formation of silica shell. Proper substitution of ligands on the QD surface in the early stages of silica shell formation was important for uniform coating reaction. An amount of toluene as QD solvent determined the size of reverse micelles during the silica shell formation. There was an optimum combination of inverse micelle size and silica shell size to obtain silica-coated QDs with good monodispersity and high shape symmetry. We succeeded in growing the thick silica shell with expanding reverse micelle size by additionally supplying toluene with the raw material using the optimum silica-coated QDs as a growth nucleus.
Diode pumped visible Dy3+-doped silica fiber laser: Ge-co-doping effects on lasing efficiency and photodarkening
Authors: Okazaki Tomoya , Otsuka Chiaki , Sekiya Edson H. , Kawai Kota , Mizusaki Masato , Kanbayashi Yuta , Saito Kazuya
Published: November 2021

We present the first demonstration of visible laser oscillation in the Dy3+-doped silica fiber pumped by a 451 nm InGaN laser diode. It was found that Ge-co-doping plays the following important roles of laser oscillation: (1) to reduce the Rayleigh scattering loss, (2) to suppress the X-ray-induced and pump-induced photodarkening (PD), and (3) to increase lasing slope efficiency. In a fiber with 0.46 wt% Dy, 1.8 wt% Ge, and 0.54 wt% Al, the slope efficiency is 22.0% at 582.5 nm, and the maximum output power is 18.4 mW.
A Review on Mechanical Properties of Sustainable Concrete by using Rise husk ash and hydrated lime
Authors:   M.Tech Scholar, Department of Civil Engineering, Vaagdevi College of Engineering, Warangal, India., Srinath Doddipati , Ramesh Gomasa ,   M.Tech Scholar, Department of Civil Engineering, Vaagdevi College of Engineering, Warangal, India.
Published: November 2021

Concrete is a commonly used construction material all over the globe. Environmentally conscious construction is essential in today's society. By using the proper materials, we may achieve long-term construction. RHA is often used as a cementitious product replacement, and in such cases, we may mix RHA with hydrated lime. Many research has been conducted on RHA, and they all indicate that it outperforms other kinds of concrete. The importance of rice husk ash in construction and its applications are the subject of this essay. Many studies have been undertaken to identify appropriate replacements for cement in concrete mixes to reduce our over-reliance on cement as a component in concrete production owing to its contribution to CO2 emissions. This article examined the research on the usage of fly ash and rice husk ash as partial concrete replacements and the chemical composition of these materials, and their impact on concrete compressive strength. The mix was created using a logical approach in which solid components were set, and water and superplasticizer content were modified to get the best viscosity and flowability. Rice husk ash (RHA) is a rice milling byproduct. Its usage as a soil stabilizer provides an environmentally friendly alternative to ultimate disposal. Because RHA is not self-cementitious, a hydraulic binder, such as lime, must be added to create cement types to strengthen the soil. In sandy soils, studies on stabilization using RHA and lime mixtures were carried out. RHA of rice husk incineration in ordinary ovens with no temperature control and laboratory burning at regulated temperatures were utilized. In soil mixes with varying RHA and lime concentrations, cementitious compounds were found to develop. Soils treated with RHA and lime underwent unconfined compression strength testing. All RHA and lime concentrations and periods tested showed strength gains, and all materials created were changed rather than stabilized. The use of RHA to improve sandy soils offers environmental, social, and economic advantages as an alternative to ultimate disposal
An Experimental Study on Mechanical Properties of Self Compacting Concrete by using Fiber Reinforcement
Authors:   M.Tech Scholar, Department of Civil Engineering, Vaagdevi College of Engineering, Warangal, India., Anil Gopu , Ramesh Gomasa ,   M.Tech Scholar, Department of Civil Engineering, Vaagdevi College of Engineering, Warangal, India
Published: November 2021

The invention of Self Compacting Concrete has been tremendous and continuing growth in the working area over the past decade, culminating in its widespread usage in today's reality. It outperforms regular cement in application and completion,cost, work reserve funds, and solidity. The addition of strands enhances its qualities, particularly those related to SCC's post- break behaviour. The goal is to investigate the strength properties of SCC when mixed with various types of strands. Different strand types and filament speeds are among the variables studied. The essential characteristics of SCC, including strength, break energy, sturdiness, and sorptivity, must be controlled. The hydrated design and security development between fiber and blend will be examined using an electron microscope to examine the tiny building of several mixes. 12mm cut glass fiber, carbon fiber, and basalt fiber will be used in the request, as they have been for quite some time. 0.0 percent, 0.1 percent, 0.15 percent, 0.2 percent, 0.25 percent, and 0.3 percent of strands are removed based on volume. The request is broken down into two parts. The first half involves creating a planned blend for SCC of a detailed assessment, such as M30. The second half involves adding filaments such as glass, basalt, and carbon strands to the SCC blends and evaluating and verifying their plastic and hardened properties. The experiment demonstrates a modest improvement in SCC aspects by adding strands of various types and altering the volume. Carbon fiber is the most improved in the more challenging state, followed by Basalt fiber and Glass fiber, and the least improved in the plastic state due to its high-water absorption. Glass fiber fared better in the plastic state. Basalt fiber fared better in the present study regarding cost, appropriate amount, and overall viability
The Mechanical Behavior of Grouted Sleeve Splice Connections with and without Mechanical Interlocking Ring Under Axial Tensile Load
Authors:   lecturer Assistant, Structural Engineering Department, Faculty of Engineering, October High Institute, OHI, Giza, Egypt., Soliman Abdallh M. , Ibrahim Hatem H. ,   Assistant Professor, Structural Engineering Department, Faculty of Engineering, Cairo University, Giza, Egypt, Hodhod Hossam A. ,   professor, structural Engineering Department, Faculty of Engineering, Cairo University, Giza, Egypt.
Published: November 2021

This research work thus presents rational procedure to design a grouted sleeve splice connection using a basic material such as standard pipes with little workmanship this provides the design with a good advantage in comparison to just using selection tables for costly proprietary similar connection. The mechanical behavior of such splices is a function of two important mechanisms: the bar-to-grout bond behavior and the sleeve-to-grout bond behavior. To accomplish the goal of this examination work, three arrangements with an all-out number of 66 grouted splice sleeve specimens were fabricated and tested under incremental axial tensile load. The specimens were preliminary designed according to the equations available in the literature to determine the initial sleeve dimensions. Different parameters have been examined, namely: grout compressive strength, bar embedded length, bar diameter, sleeve inner diameter, sleeve wall thickness and sleeve configuration. The examined parameters provide to have a significant impact on the mechanical behavior of the grouted splices. Considering the results, it was clear that steel bars with 18 mm, 25 mm and 32 mm diameter and 044 Mpa yield stress can be adequately spliced and the tensile strength can be reached. The steel sleeve to the grouted splice sleeve connectors significantly improve the bar-to-grout bond strength through the confinement action added by the sleeve wall. Also welding interlocking steel rings can prevent the grout-to-sleeve bond Failure. Feasibility study for tested grouted sleeves reporting their adequacy in accordance with the code provisions of ACI 318-14[1] and ECP 203-2018[5] is presented. Moreover, design equations capturing the parameters affecting the bond strength, the confining pressure, and the required embedment length are derived.