bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of lesion characteristics on diagnostic performance of CT-derived fractional flow reserve: exploring the indications for application based on CT-FFR CHINA trial (Preprint)
Authors: Zhao Na , Gao Yang , Xu Bo , Yang Weixian , Song Lei , Jiang Tao , Xu Li , Hu Hongjie , Li Lin , Chen Wenqiang , Li Dumin , Zhang Feng , Fan Lijuan , Liu Bin
Published: November 2021

BACKGROUND

High diagnostic performance of coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFR; CT-FFR) in identifying flow-limiting stenosis has been confirmed. CT-FFR is recommended to assess the hemodynamic significance of coronary lesions. However, the optimal indications of CT-FFR relies on its ability to discriminating ischemia in situations of different types of lesions. And the effect of lesion-dependent factors on determining the diagnostic accuracy of CT-FFR have not been comprehensively evaluated yet.

OBJECTIVE

We aimed to investigate the effect of lesion-related factors on the diagnostic performance of CT-FFR with computational fluid dynamics algorithm, to promote the clinical application of it.

METHODS

This multicenter prospective clinical trial enrolled 317 patients with 30%–90% stenosis undergoing CCTA and invasive FFR from 5 centers across China. All target lesions were assigned into different lesion characteristics (target vessels, lesion location, lesion length, bifurcation lesions, and coronary calcification) subgroups. Diagnostic performance (accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under receiver operating characteristics curve (AUC)) of CT-FFR identifying ischemia were calculated and compared in all sub-groups.

RESULTS

Three hundred and sixty-six target vessels from 317 patients (mean age: 59.3 ± 9.6 years) were analyzed. The overall vessel-based diagnostic accuracy, sensitivity, specificity, PPV, NPV, and AUC of CT-FFR were 87.2%, 86.4%, 88.8%, 86.9%, 88.4%, and 0.90. Absence of bifurcation lesion group possessed the higher NPV of CT-FFR than presence of bifurcation lesion group (92.8% vs. 78.9%, p = 0.006). Whereas there was no statistically significant difference in diagnostic performance of CT-FFR among different target vessels, lesion location, lesion length, and coronary calcification sub-groups (all p > 0.05).

CONCLUSIONS

This study supported CT-FFR as a powerful noninvasive functional assessment tool for coronary lesions with different lesion characteristics, involving target vessel, lesion location, lesion length, and coronary calcification. While the diagnostic performance of CT-FFR was negatively affected by the presence of bifurcation lesions.

CLINICALTRIAL

https://clinicaltrials.gov; Unique identifier: NCT03692936.
A Smart Mobile App to Simplify Medical Documents and Improve Health Literacy: System Design and Feasibility Validation (Preprint)
Authors: Hendawi Rasha , Alian Shadi , Li Juan
Published: November 2021

BACKGROUND

People with low health literacy experience more challenges in understanding instructions given by their health providers, following prescriptions, and understanding their health care system sufficiently to obtain the maximum benefits. People with insufficient health literacy have high risk of making medical mistakes, more chances of experiencing adverse drug effects, and inferior control of chronic diseases.

OBJECTIVE

This study aims to design, develop, and evaluate a mobile health app, MediReader, to help individuals better understand complex medical materials and improve their health literacy.

METHODS

MediReader is designed and implemented through several steps, which are as follows: measure and understand an individual’s health literacy level; identify medical terminologies that the individual may not understand based on their health literacy; annotate and interpret the identified medical terminologies tailored to the individual’s reading skill levels, with meanings defined in the appropriate external knowledge sources; evaluate MediReader using task-based user study and satisfaction surveys.

RESULTS

On the basis of the comparison with a control group, user study results demonstrate that MediReader can improve users’ understanding of medical documents. This improvement is particularly significant for users with low health literacy levels. The satisfaction survey showed that users are satisfied with the tool in general.

CONCLUSIONS

MediReader provides an easy-to-use interface for users to read and understand medical documents. It can effectively identify medical terms that a user may not understand, and then, annotate and interpret them with appropriate meanings using languages that the user can understand. Experimental results demonstrate the feasibility of using this tool to improve an individual’s understanding of medical materials.
A Tale of Two Surfers: Joy and Wellbeing in Mature Participants
Authors: Maitland Nick , Light Richard L
Published: November 2021

Within larger concern over wellbeing at a global level, there is growing interest in the role that sport can play in developing positive wellbeing with a focus on young people. Lifestyle sports that people participate in for pleasure rather than competition are likely to offer opportunity to develop wellbeing but research on them neglects middle aged participants. This article redresses this oversight by focusing on two surfers, with one male and one female, in their forties to explore the role that surfing plays in their lives and its contribution to their wellbeing. Using a narrative inquiry approach it explores the place of surfing in their lives over three decades to identify how its meaning changed as they matured and how it offered a highly effective coping mechanism for dealing with life’s stresses and pressures.
БЕСПЛАТФОРМЕННЫЙ ИНЕРЦИАЛЬНЫЙ БЛОК ДЛЯ СИСТЕМЫ АКТИВНОЙ БЕЗОПАСНОСТИ ТРАНСПОРТНОГО СРЕДСТВА
Authors: Ачильдиев В.М. , Грузевич Ю.К. , Солдатенков В.А. , Бедро Н.А. , Рулев М.Е. , Журавлев Н.М.
Published: November 2021

Доклад посвящен разработке и исследованию системы активной безопасности транспортных средств. Описан алгоритм работы антиблокировочной, противобуксовочной систем и системы курсовой устойчивости с использованием бесплатформенного инерциального блока. Представлены результаты исследований и испытаний.
ОСОБЕННОСТИ ГОТОВЫХ ПРОГРАММНОАППАРАТНЫХ РЕШЕНИЙ ДЛЯ ТЕСТИРОВАНИЯ ПАРАМЕТРОВ МИС. ПУТЬ К РАЗРАБОТКЕ АВТОМАТИЗИРОВАННОГО ИЗМЕРИТЕЛЬНОГО КОМПЛЕКСА РЕАЛЬНОГО ВРЕМЕНИ
Authors: Сметанин В.В.
Published: November 2021

Дана оценка возможности создания автоматизированного измерительного комплекса для тестирования параметров СВЧ МИС на базе программно-аппаратных решений от ведущих производителей измерительного оборудования. Предложен проект разработки собственного автоматизированного измерительного комплекса с отличительными признаками системы реального времени.
МЕМРИСТОРНЫЕ СТРУКТУРЫ НА ОСНОВЕ ЭЛЕКТРОХИМИЧЕСКОГО ОКСИДА ТИТАНА ДЛЯ RERAM И НЕЙРОМОРФНЫХ ПРИМЕНЕНИЙ
Authors: Смирнов В.А. , Авилов В.И. , Томинов Р.В. , Федотов А.А. , Агеев О.А. , Валов И.
Published: November 2021

Представлены результаты экспериментальных исследований влияния толщины наноструктур оксида титана, полученных локальным анодным окислением, на их мемристивные свойства. Показана возможность управляемого формирования мемристивных структур, не требующих формовки, имеющих напряжение переключения менее 3 В.
АССОЦИАТИВНАЯ ПАМЯТЬ СИСТЕМЫ АНТИФЕРРОМАГНИТНЫХ ОСЦИЛЛЯТОРОВ ДЛЯ ЗАДАЧИ РАСПОЗНАВАНИЯ ИЗОБРАЖЕНИЙ
Authors: Митрофанова А.Ю. , Сафин А.Р. , Егоров Д.П. , Кравченко О.В. , Базенков Н.И.
Published: November 2021

Реализована ассоциативная память на основе ансамбля антиферромагнитных спинтронных осцилляторов для задачи распознавания изображений. Приведены примеры распознаваемых и восстановленных образов. Представлены ошибки классификации для разных значений отношения сигнала к шуму и разного количества распознаваемых образов.
DAG-MAM AND REMOTE CONTROL SYSTEM (UKEP)
Authors: Balbay R. , Aydemir O. F. , Ozturk I. , Yesilyaprak C.
Published: November 2021

One of the problems that arise during the DAG-MAM project is the problem of access to the devices. A prototype has been produced for the idea of UKEP which designed to eliminate the deficiency in the DAG-MAM system. It has performed suffciently compared to the devices that can be considered as equivalent in the market.
Aerodynamic Analysis of Novel Savonius Rotor
Authors: Varia Manthan N.
Published: November 2021

Abstract: Wind is a renewable form of energy that holds vital solutions to energy crisis that will be faced in the possible future. Apart from the viable lift based turbines that we have been working on, research can be done on drag based turbines that can be installed in urban areas for short power requirements. The research aims at developing a novel design for Savonius type rotor which will help to improve the power producing characteristics of the turbine. CFD fluent analysis will help in analysis of the proposed blade shape. The results explain how the combination of elliptical profiled blade improves coefficient of power for Savonius type rotor. Keywords: Aerodynamics, Wind Energy, Savonius, VAWT, Wind Turbine
Effect of Recrystallization Technique on Oral Bioavailability of Valsartan
Authors: Rao TP , Nalluri N.
Published: November 2021

Valsartan (VAL) is a widely prescribed anti-hypertensive agent with angiotensin II type I receptor antagonistic activity. VAL belongs to BCS class II having a low and variable oral bioavailability (10-35%) and its absorption is dissolution rate limited. Recrystallization of VAL from different organic solvents improved VAL aqueous solubility and thereby in vitro dissolution properties. In this investigation in vivo oral bioavailability (BA) of VAL and its recrystallized products with methanol and ethanol (VMET and VETH respectively) solvents was evaluated in male Wistar rats. Also, a rapid, economical and reliable RP-HPLC-PDA method was developed for the estimation of VAL in rat plasma samples and validated according to ICH guidelines. Chromatographic separation was achieved on an Agilent eclipse C18 column (150×4.6mm, 5µ) with a mobile phase composition of 10mM ammonium acetate: acetonitrile (75:25%v/v) at a flow rate of 1.2 mL/min. The retention time of VAL was found to be 2.9 min and showed good linearity (R2>0.996) in the selected concentration range of 0.5-25µg/mL. A 2.9, 2.8 folds increase in Cmax and a relative bioavailability of 320, 305% was observed with VMET and VETH respectively, when compared to that of untreated VAL. Thus it can be inferred that recrystallization is easy and economical technique for enhancing the pharmaceutical properties like solubility, dissolution properties and oral BA of poorly water soluble drugs like VAL.

Keywords: Bioanalytical method, Bioavailability, Male Wistar rats, Valsartan, Recrystallization
Specialised Coating Processes Finding Pharmaceutical Applicability
Authors: Saikh Mahammed Athar Alli , Mohapatra Prithwiraj
Published: November 2021

The manuscript aims at furnishing comprehensive information pertaining specialised coating technology/ processes. Solid dosage forms and solid particulates (SDFSP) are the major contributing group in the solid pharmaceuticals (SoPs). SDFSP exhibit peculiar physico-chemical properties and interaction behaviour which create problems/ issues during their handling, processing, storage, and use. Modifying and/or engineering surface attributes of SDFSP are advocated as powerful tool to modify their interaction behaviour and realise their worthy applications and functionalities. In this regard coating their surfaces with coating material (CM) is novel approach. Said approach involves wet and dry process for realising deposition of CM onto the surface of SDFSP substrates. Both the processes modify and/or alter innate properties of SDFSP substrates either physically or chemically. Basing on involved wet or dry process the coating method is either dry coating method (DCM) or wet coating method (WCM). Accordingly nowadays there available number of specialised devices, that bases on diverse technologies. Amongst them some involves state-of-art process/ technology like Supercell coating technology (SCT), Chemical vapour deposition (CVD), Atomic/molecular layer deposition (AMLD), Electrostatic deposition, Thermo-mechanical process, Resonant acoustic technology, Fluidised-bed process, Supercritical fluid (SCF) technology,  and others. These foundational for commercially availability of specialised equipments like Magnetically Assisted Impaction Coater (MAIC), Resodyn acoustic mixer, Hybridizer®, Theta-composer®. Mechanofusion®, and others. Working and working principle, applicability, benefits, pros and limitations of specialised coating processes and technologies are herein discussed and presented. Contained information hoped to be beneficent for pharmaceutical professionals and technocrats and professionals of allied field.

Keywords: Coating, composite product, modification, specialised, surface.
Tapentadol: Use and Abuse
Authors: Juvin Thomas CV , Sambathkumar R , Venkateswaramurthy N
Published: November 2021

Tapentadol is a synthetic opioid analgesic that has been on the market in India since 2011. According to international studies, there is a low danger of abuse and diversion. Prescription opioid pain reliever abuse remains a major public health concern. Tapentadol, a prescription painkiller, differs from opioids such as oxycodone and morphine in that it has two modes of action: opioid receptor agonism and norepinephrine reuptake inhibition. Tapentadol has been on the market in India for eight and a half years. Our center was the topic of a single peer-reviewed research in 2017 that detailed two instances of abuse. Tapentadol is less likely to be diverted, abused, addicted, overdosed, or sold on the street than other prescribed opioids. This article reviews uses, pharmacological properties and abuse of tapentadol as it is the most serious issues like addiction, seeking behavior, withdrawal, and physical dependency .The main challenge with tapentadol use is controlling the ratio of MOR agonist to NRI. Finally, tapentadol provides both nociceptive and neuropathic pain relief, but there are concerns about abuse and reliance.

Keywords: Tapentadol, Abuse, Opioid, Addiction.
UPAYA PERDAMAIAN UNTUK PENYELESAIAN PERKARA PIDANA Reaktualisasi Kearifan Lokal dalam Hukum pidana Indonesia
Authors: Muhammad Rusjdi Ali
Published: November 2021

One characteristic of Islamic law is not explicitly distinguished between the domain of public law with private law. Sanctions for deliberate murder is Qisas for example, where the victim's heirs have more permanent role to choose the death penalty imposed (Qisas) or give forgive me by asking Diyat (compensation). Amount number of Diyat is also can be negotiated through a kind of mediation method called Shulh (peace). So here the element of private law is more dominant. Even Diyat can be released at all heirs of the victim initiatives. In this last case the State may punish the offender with ta'zir, so here its public law elements recur. This idea is not unknown in Indonesian positive law provisions. The victim had usually been involved as a witness in his father murder case or rape case against her. In customary law in Aceh there are several institutions in efforts to realize peace for criminal cases, namely in the form of adat meulangga, dhiet, sayam or takanai (South Aceh). Principles of peace settlement of disputes may also be considered not only for civil cases but also in criminal cases. Thus the doctrine that says the criminal nature of a case will not remove although there is peace agreement, would need to be revisited. However it is important also to restrict that not every criminal case could be solved by peace agreement. Criminal cases like premeditated murder and rape should be excluded from the possibility of peace agreement.
TAUBAT SEBAGAI PENGHAPUS HAD ZINA MENURUT IBNU TAIMIYYAH
Authors: Syuhada Syuhada , Zulkiram Zulkiram
Published: November 2021

Scholars differ on whether the repentance of an adulterer can abrogate the punishment of the limit ?. Some scholars state that there is no fall at all, while others state that the punishment is limited to fall. In this regard, Ibn Taymiyyah's opinion is the same as the last opinion that the repentance of an adulterer can remove the demand of the limit as long as it has not been submitted to the ruler, but if it has been submitted to the ruler then the limit does not fall so it remains punished and his repentance is accepted by Allah SWT. As for the research method is qualitative, the type of literature research, research data from library materials in the form of books of jurisprudence, law, and other relevant literature then the data that has been collected, both from primary, secondary, and tertiary data, then analyzed by descriptive-analysis. The results of the study showed that according to Ibn Taymiyyah, the perpetrator of adultery who repented before being complained to the government, fell ḥadd adultery. The perpetrator does not have to admit his actions because the attitude is seen as better. As for the adulterer who repents after being complained to the government, then it does not fall ḥadd adultery. The perpetrator must still be punished, his repentance is accepted by Allah SWT., While the punishment of ḥadd as a consummation of his repentance. The argument used by Ibn Taymiyyah about the fall of ḥadd zina due to repentance refers to the provisions of the QS. al-Nisā 'verse 16, QS. al-Māidah verses 33-34, QS. Ṭāhā verses 121-122, and the hadith narrated by Abū Dawud about the punishment of Maiz. The method of istinbāṭ that he uses tends to use heroic reasoning, that is, looking at the sides and rules of language, general and special relations, cause and effect, and understanding the words of the Qur'an.
How The Chinese Think about the Family: The ‘Family’ in Chinese Family Firms
Authors: Wong Heung Wah
Published: November 2021

How The Chinese Think about the Family: The ‘Family’ in Chinese Family Firms
Witches, Business & Culture: Anthropologists as Professional Strangers in the Boardroom
Authors: Schönhuth Michael
Published: November 2021

This article collates personal insights from 30 years of research and consultancy in organisational anthropology. It has two target groups in mind: on the one hand, students who, after completing a degree in anthropology with a more classical focus, are wondering what they can do with and how they could ‘sell’ their professional skills outside the academy, in the field of organizational consulting or organizational development. On the other hand, it wants to open the black box of anthropological methods and procedures for decision makers in organizations, enabling them to decide whether and when the use of anthropological expertise in their own company is worthwhile, especially in times of global flows of people, goods and communication. Here, the free-flying witch stands as a metaphor for the anthropological position as a professional stranger at the interface of the corporate world.
GRP75 Regulates Mitochondrial-Supercomplex Turnover to Modulate Insulin Sensitivity
Authors: Zhao Qiongya , Luo Ting , Gao Feng , Fu Yinxu , Li Bin , Shao Xiaoli , Chen Haifeng , Zhou Zhuohua , Guo Sihan , Shen Lijun , Jin Liqin , Cen Dong , Zhou Huaibin , Lyu Jianxin , Fang Hezhi
Published: November 2021

GRP75 (75-kDA glucose-regulated protein), defined as a major component of both the mitochondrial quality control system and mitochondria-associated membrane, plays a key role in mitochondrial homeostasis. In this study, we assessed the roles of GRP75, other than as a component, in insulin action in both in vitro and in vivo models with insulin resistance. We found that GRP75 was downregulated in mice fed a high-fat diet (HFD) and that induction of Grp75 in mice could prevent HFD-induced obesity and insulin resistance. Mechanistically, GRP75 influenced insulin sensitivity by regulating mitochondrial function through its modulation of mitochondrial-supercomplex turnover rather than mitochondria-associated membrane communication: GRP75 was negatively associated with respiratory chain complex activity and was essential for mitochondrial-supercomplex assembly and stabilization. Moreover, mitochondrial dysfunction in Grp75-knockdown cells might further increase mitochondrial fragmentation, thus triggering cytosolic mtDNA release and activating the cGAS/STING-dependent proinflammatory response. Therefore, GRP75 can serve as a potential therapeutic target of insulin resistant-related diabetes or other metabolic diseases.
Development of Verruca Plana from Human Papillomavirus 78 Dependent on Host Immune State
Authors: Shimano Mayuna , Miyauchi Toshinari , Yanagi Teruki , Nomura Toshifumi , Ujiie Hideyuki
Published: November 2021

Abstract is missing (Short communication)
Harbouring Aliens: Ports as Habitats for Non-native Species
Authors:   , Holmes Samuel J.
Published: November 2021

Non-native species are widely regarded as a significant environmental threat and have been associated with biodiversity loss, species extinctions and the altering of ecosystem services. Shipping is the largest transport vector for aquatic species worldwide and ports, being central to this industry, are considered potential ‘hotspots’ for non-native species introductions. Ports are often heavily industrialised areas which can hinder access and the use of standard survey methods. As such, our knowledge of non-native species within UK ports is poor. As the foundation for this research I developed two different settlement surveys designed specifically to overcome some of the obstacles associated with working within active port environments. Surveys were deployed across five ports in South Wales, UK. I detected 13 non-native species and described the wider fouling communities present within each studied port. Whole community structure and their succession varied highly between ports, with salinity being the primary driver of differences between port communities. Significant differences in the observed non-native species between ports, independent of geographic proximity, highlighted the need to monitor individual ports with a view to implementing bespoke, effective management strategies. Colonisation of different material substrates was quantified and revealed that whilst the community structure varied between material types, non-native species would readily colonise all studied materials. These findings have particular importance for the management of non-native species within ports and have been used to inform port biosecurity procedures within the studied region. The successful deployment of the tailored survey methods within active ports will encourage regular monitoring for non-native species within UK ports. This research also showed that collaborations between researchers and port authorities can be highly effective for both parties and may indeed be necessary if we are to successfully manage aquatic non-native species within the UK.
Konsep Pendidikan Profesional Perspektif Undang-Undang tentang Guru dan Dosen
Authors: Sutarsih Eti , Misbah M
Published: November 2021

Abstract

 

Educators must have an attitude in dealing with students so that they are in accordance with the teachings conveyed by Islam. Educators need to know and be aware of the profession that is taken as a calling for the soul to be able to achieve a maximum learning goal, they need to know and practice several tasks as professional educators. Professional educators are regulated in the Law on Teachers and Lecturers. Therefore, it is important for an educator to learn and implement it to become a professional educator. This research uses descriptive analysis method. This type of research is carried out on national and international literature review sources related to the concept of professional educators. Professional educators must carry out their duties as educators as stated in the law on teachers and lecturers. Professional educators must have educator competencies in carrying out their responsibilities in educating, teaching, guiding, assessing, training, and evaluating students. In addition, the quality of an educator will continue to improve, which in the end, the quality of educational institutions will also have quality. Professional educators will continue to strive to develop themselves according to the times. Has the nature and character that is in accordance with the duties or obligations as an educator

 

Keywords

Educators, Professional, and Law

 

 

Abstrak

 

Pendidik harus memiliki sikap dalam menangani peserta didik agar sesuai dengan ajaran yang disampaikan oleh agama Islam. Pendidik perlu mengetahui dan sadar akan profesi yang diambil sebagai panggilan jiwa untuk dapat mencapai sebuah tujuan pembelajaran yang maksimal perlu mengetahui dan mengamalkan beberapa tugas sebagai pendidik professional. Pendidik profesional sudah diatur dalam Undang-Undang tentang Guru dan Dosen. Oleh karena itu, pentingnya seorang pendidik mempelajari dan melaksanakan untuk menjadi pendidik yang profesional. Penelitian ini menggunakan metode analisis deksriptif. Jenis penelitian yang dilakukan pada sumber-sumber kajian pustaka nasional maupun internasional yang berhubungan dengan konsep pendidik profesional. Pendidik profesional harus menjalankan tugas sebagai pendidik yang telah tercantum di dalam undang-undang tentang guru dan dosen. Pendidik profesional harus memiliki kompetensi-kompetensi pendidik dalam menjalankan tanggung jawab dalam mendidik, mengajar, membimbing, menilai, melatih serta mengevaluasi peserta didik.  Selain itu, kualitas yang dimiliki seorang pendidik akan terus meningkat yang pada akhirnya kualitas lembaga pendidikan juga akan ikut bekualitas. Pendidik profesional akan terus berusaha untuk mengembangkan diri sesuai dengan perkembangan zaman. Memiliki sifat dan karakter yang sesuai dengan tugas atau kewajiban sebagai pendidik.

 

Kata Kunci

Pendidik, Profesional, dan Undang-Undang
Peran Pustakawan dalam Pendampingan Penggunaan Media Sosial Terhadap Perilaku Remaja di Masyarakat
Authors: Mustar Maniso
Published: November 2021

Introduction. Information and communication technology develops very rapidly. Without exception, social media thrives in all circles including teenagers. Social media gives benefits in life and able to provide positive impacts in economic, social and cultural. However, in the midst of the widespread use of social media, sometimes users are not aware of the negative impacts such as social media influences towards teenagers behaviours. This article aims to assist teenagers in controlling behavior due to the influence of social media in society.

Methodology. This research use descriptive method. Data collection and analysis was done with literature review from various references.

Results and Discussion. This research show that social media influences teenagersâ€™ behavior by bridging activites and friendship which may bring positive and negative impacts. Librarians may have roles in social media by giving positive values through providing constructive information which has value economically, culturally and socially among teenagers and wider community.

Conclusion. Librarians can help the community by giving accompaniment in social media usage and shaping teenagers characters through attitudes, patriotic behavior, upholding democracy and towards civil society that applies knowledge responsibly towards humanity through planned programs.
Resepsi Al-Quran Di Pondok Pesantren Al-Hidayah Karangsuci Purwokerto
Authors: Zaman Akhmad roja Badrus
Published: November 2021

The Qur'an is truly a holy book containing moral teachings to guide people to the straight path. It's just that, when the Qur'an is consumed by the public, the book experiences a paradigm shift so that it is treated, received, and expressed differently according to their respective knowledge and beliefs. That expression, of course, is a concrete indicator that the Qur'an is a holy book which is always in harmony with all situations and conditions (á¹£Älih li kulli zamÄn wa makÄn). The model and style of the reception even now continue to be expressed and preserved by the family of Ponpes Al-Hidayah Karangsuci, Purwokerto. This study aims to determine the variety of Al-Qur'an receptions in Ponpes and try to understand the meaning inherent in it. This research was designed with qualitative methods and included in field research. In obtaining data, the instruments that researchers use are in-depth interviews, observations, and studies of related documents. The analysis used by researchers is as presented by Mohd. Soehadha, namely by reducing data, displaying data, and drawing conclusions. In clarifying the validity of the data, the researcher extends the participation and triangulation of sources and methods. From the research conducted, the results obtained include: (1) a variety of Al-Qur'an receptions in the Al-Hidayah Islamic Boarding School Karangsuci Purwokerto, (2) The meanings inherent in the reception variety, among others: objective meaning, expressive meaning, and documentary meaning. The objective meaning is to conclude that the variety of reception behavior at the Islamic boarding school is a symbol of compliance and injustice to the regulations of the boarding school. The expressive meaning is a form of self-internalization with positive things through the continuous learning process of the Qur'an, and the meaning of the documentary is a form of local contextualization of the whole cultural system.
Otak dan Akal dalam Ayat-Ayat Neurosains
Authors: Noor Fuad Arif
Published: November 2021

Neuroscience is simply the science that specifically studies Neurons (nerve cells). These nerve cells make up the nervous system, both the central nervous system (brain and spinal cord) and peripheral nerves (31 pairs of spinal nerves and 12 pairs of head nerves). Nerve cells themselves are no longer the smallest unit of nerve cells, the smallest unit of nerve cells (neurons) in synapses, which are the meeting points of two nerve cells that move and forward information (neurotransmitters). At the level of molecular biology, the smallest units are like genes (genetic studies). Generally, neuroscientists focus on nerve cells in the brain. In the Qur'an, the mind has a noble position. It was proven that the word "reason" in the Qur'an is mentioned in large numbers. The word "reason" in the Qur'an is mentioned 49 times. All of them are in the form of 'muilÄri' (a verb that indicates the present and the future), except for the one in the form of 'mÄá¸Ä« (a verb denoting the past). Although the Qur'an does not mention "reason" in its form as "a certain part of humanity" (Ø¬ÙˆÙ‡Ø±Ø§ Ù…Ø³ØªÙ‚Ù„Ø§ ÙÙ‰ Ø§Ù„Ù†ÙØ³), which is the source of birth for all rational actions, but the Qur'an refers to "reason" in its meaning as " activities using reason '(Ø¹Ù…Ù„ÙŠØ© Ø§Ù„ØªØ¹Ù‚Ù„), i.e. calls to use reason as a path to truth (Ø§Ù„ØªØ¹Ù‚Ù„), think (Ø§Ù„ØªÙÙƒØ±), pay attention (Ø§Ù„Ù†Ø¸Ø±), understand and learn (Ø§Ù„ØªÙÙ‚Ù‡), take wisdom and lessons from each event (Ø§Ù„Ø§Ø¹ØªØ¨Ø§Ø±), etc.
Клинический случай длительной гипоосмии после перенесенной короновирусной инфекции
Authors: Дума Светлана
Published: November 2021

Эффективное лечение длительной гипосмии ( более 4-х месяцев) после перенесенной

короновирусной инфекции.До сих пор только предполагается, что длительно

сохраняющаяся гипо и аносмия (более 15–20 дней) обусловлена возможным поражением

непосредственно обонятельных рецепторных клеток, естественный период

восстановления которых может затянуться до 2 месяцев.

Также не следует недооценивать значимость обоняния для пациента, так как

хемосенсорная дисфункция не только снижает качество жизни, но и может привести к

тяжелым неврологическим и нейропсихиатрическим осложнениям (например, к

депрессии, когнитивным нарушениям и др.).
Клинический случай постковидных когнитивных нарушений и астении у молодого человека: возможности терапии
Authors: Кононова Елена
Published: November 2021

В предложенном клиническом случае рассмотрены возможности терапии для восстановления субъективных когнитивных нарушений и уменьшения астении (усталости) у девятнадцатилетнего молодого человека, перенёсшего СОVID -19 в июне 2021. Представленный клинический случай призван привлечь внимание специалистов к пациентам с подобными нарушениями, часто возникающими в постковидный период, и обосновывает необходимость их медикаментозного лечения.
Ab Initio Calculation of Li-Sn System: Unraveling New Phases of Superconducting Materials with Increasing Compression
Authors: Lim Thong Leng , Yoon Tiem Leong , Chang Yee Hui Robin , Lai San Kiong
Published: November 2021

Stoichiometry, crystal compound, electronic attributes and superconductivity of compressed lithium-tin composites have been thoroughly studied using quantum mechanical genetic algorithm approach and the first principles computations based on density functional theory. Our simulations at moderate pressure (5-20 GPa) predict a complex convex hull diagram, with the following stable Li‑rich phases: I4/mmm-Li6Sn2, -Li7Sn2, -Li5Sn2, Ama2-Li4Sn2, -Li5Sn2, -Li6Sn2, C2/m-Li4Sn1, P21/m-Li6Sn2, -Li7Sn2 and Cmcm-Li4Sn2. Careful examination at their independent elastic parameters reveals sufficient mechanical stability in them. These phases are metallic system, with reasonably high electron concentration near to Fermi level or N(EF) that ranges from 0.6 to 2.4 states/eV cell. It is also interesting for us to observe soft modes and steep-flat energy bands at Fermi levels of Li6Sn2 structures which are stable throughout the pressure range. These features are prerequisites for superconducting behavior. Linear response function with Gaussian and tetrahedron methods reveals satisfactory superconducting transition temperature Tc (3.1 ~ 6.6 K) and Tc (2.1 ~ 2.4 K), respectively. Structural transition results for based elements Li and Sn agree well with literature thus signifying reliable prediction of intermediate phases.
Challenges and Way Forward for Implementing Green Roof in Construction Industry in Sarawak, Malaysia
Authors: Abdul Rahim Nurul Nabilah , Mohamad Bohari Asmah Alia , Adnan Amira Shazlin , Khalil Natasha , Olanipekun Ayokunle Olubunmi
Published: November 2021

There is a growing global concern about the adverse effects of today's rapid economic growth and development, which impact the environment and deplete energy supply. A green roof may lower a building's energy consumption and minimise air pollution by reducing dust particles in the air. The primary impediment to green roof implementation in Malaysia lacks local knowledge and unskilled green roof specialists. As a result, there is a shortage of green roof installers and specialised firms in the country. This article discusses the problems and solutions of adopting green roofs in building projects based on construction industry experience in Sarawak. A survey utilising a questionnaire is used to obtain data for this research. The paper revealed the possible challenges of adopting a green roof for the construction industry. The study is critical in order to adopt green roof technology quickly in Malaysia.
Predicting AAK1/GAK Dual-Target Inhibitor against SARS-CoV-2 Viral Entry into Host Cells: An in silico Approach
Authors: Wezen Xavier Chee , Wen Clement Sim Jun , Ping Lilian Siaw Yung , Ho Yeong Kah , Qing Kong Hao , Ha Christopher , San Hwang Siaw
Published: November 2021

Clathrin-mediated endocytosis (CME) is a normal biological process where cellular contents are transported into the cells. However, this process is often hijacked by different viruses to enter host cells and cause infections. Recently, two proteins that regulate CME – AAK1 and GAK – have been proposed as potential therapeutic targets for designing broad-spectrum antiviral drugs. In this work, we curated two compound datasets containing 83 AAK1 inhibitors and 196 GAK inhibitors each. Subsequently, machine learning methods, namely Random Forest, Elastic Net and Sequential Minimal Optimization, were used to construct Quantitative Structure Activity Relationship (QSAR) models to predict small molecule inhibitors of AAK1 and GAK. To ensure predictivity, these models were evaluated by using Leave-One-Out (LOO) cross validation and with an external test set. In all cases, our QSAR models achieved a q2LOO in range of 0.64 to 0.84 (Root Mean Squared Error; RMSE = 0.41 to 0.52) and a q2ext in range of 0.57 to 0.92 (RMSE = 0.36 to 0.61). Besides, our QSAR models were evaluated by using additional QSAR performance metrics and y-randomization test. Finally, by using a concensus scoring approach, nine chemical compounds from the Drugbank compound library were predicted as AAK1/GAK dual-target inhibitors. The electrostatic potential maps for the nine compounds were generated and compared against two known dual-target inhibitors, sunitinib and baricitinib. Our work provides the rationale to validate these nine compounds experimentally against the protein targets AAK1 and GAK.
Intolerance of Uncertainty, Anxiety and Depression in the Context of Covid-19 in Indonesia
Authors: Yuniardi Muhamad Salis , Cant Matthew , Hanif Akhtar
Published: November 2021

"This Covid-19 pandemic brings uncertainty and may lead to mental
problems. Yet, in this context, no study has examined the relationship
between intolerance of uncertainty (IU) and either anxiety or depression
during pandemic among Indonesians. This study investigated the pathway
between IU, anxiety and depression serially mediated by cognitive appraisals
(perceived severity, controllability, and knowledge) and emotional and
behavioural responses to COVID-19. Online psychological measures were
administered to 406 participants, including the IUS-12, the DASS-21,
cognitive appraisal scales, and emotional and behavioural response scale. An
indirect pathway was found between IU and depression, and the effect was
serially mediated by perceived of severity and emotional and behavioural
responses to COVID-19. Perceived knowledge and perceived controllability
of COVID-19 did not significantly contribute to the model. A similar
pathway was found for IU predicting anxiety. As conclusion, IU represents
a risk factor for heightened emotional and behavioural difficulties that
eventually, could lead to either anxiety or depression during COVID-19."
"Professional Psychological Help-Seeking Attitude of Asian
International Students in Japan"
Authors: Lim Won-Tack
Published: November 2021

"As globalization advances, the world's international student population has
continuously risen. Among this enlarged population, numerous students face
adjustment problems after realizing unfamiliarity with the host culture at
certain points in their sojourns, which often trigger severe psychological
distress. Previous studies conducted in the U.S. university settings have
pointed to the underutilization of mental health resources by international
students as one of the primary risk factors for the betterment of psychological
health. Up to the present, however, there is very limited research carried out
in places other than leading countries of North America and the British
Commonwealth on the topics of international students’ mental health.
Different from the predominant research settings of existing research, this
article attempts to clarify the distinction in professional help-seeking
willingness between Japanese domestic students and international students
from other Asian regions who were enrolled in a Japanese university,
performing an independent Two-sample Z-test analysis. The result of the
findings showed that both Japanese domestic students and Asian
international students scored below average in willingness to seek
professional help from mental health providers. It also demonstrated that the
degrees of local students’ help-seeking willingness did not significantly
differ from those of international students. Implications, limitations, and
recommendations for future research are also discussed."
"Comprehensive Assessment of ACT Processes CompACT. Romanian Adaptation and Short Form Validation"
Authors: Călinici Mirela Simona , Călinici Tudor
Published: November 2021

"The current paper presents the translation and validation for Romanian non-clinical population of Comprehensive Assessment of ACT Processes – CompACT (Francis et al., 2016), an instrument that evaluates three dimensions of psychological flexibility: openness to experience, present moment awareness (mindfulness) and valued action. The psychometric properties of the Romanian version of the instrument were investigated, convergent validity in relation with AQQ-II and concurrent validity in relation with DASS-21 (with comparable results with ones reported for the original instrument). Considering modest model fit with theoretical factor structure of the instrument, current paper proposes a shorter, more stable Romanian Version, and tests its psychometric properties."
A Systematic Review of Prevention and Intervention Strategies for Smartphone Addiction in Students: Applicability During the COVID-19 Pandemic
Authors: Liu Xiao-xia Liu
Published: November 2021

"During this coronavirus (COVID-19) pandemic, smartphones play an important role in online classes, study, and entertainment. However, excessive use may lead to smartphone addiction (SPA). The incidence of SPA among students has increased with the spread of COVID-19 and threatens to impair home-based students’ learning efficiency and physical and mental health. This study aimed to provide a comprehensive overview of the latest achievements in SPA prevention and treatment, and a theoretical basis for future experimental research and clinical treatment, while considering their applicability during the current pandemic. We researched the core literature in Chinese, English, and Korean databases from 2000 to 2021; 3208 articles were identified. After reading the titles, abstracts, and full texts, 53 articles were selected. Research on SPA interventions was relatively limited; we identified six types of prevention and treatment measures: psychotherapies, cognitive training, behavioral intervention, application restriction, social intervention, and complementary and alternative medicine. They can be implemented by students, parents, or online experts. Future research should focus on developing early measures to identify and prevent SPA and enhance students’ change motivation."
Precarização do trabalho do tradutor e intérprete de Libras educacional: impactos no ensino e saúde
Authors: França Thaisa Cristina , Souza Regina Maria de
Published: November 2021

Este artigo apresenta um recorte específico da dissertação em que se baseia, que trata da precarização do trabalho do tradutor e intérprete de Libras educacional, um campo investigativo ainda pouco explorado. A metodologia envolveu levantamento e análise de pesquisas já realizadas no campo da tradução e interpretação de Libras-Português e buscas nos sites das universidades públicas que formam intérpretes, do Sindicato Nacional dos Tradutores, da Federação Nacional de Educação e Integração dos Surdos e da Federação Brasileira das Associações dos Profissionais Tradutores e Intérpretes e Guia-intérprete em Língua de Sinais, com o objetivo de identificar os desafios encontrados pelos intérpretes em diferentes frentes, como: carga de trabalho, funções, remuneração, tempo na escola, saúde laboral e formação. A parte empírica foi apenas um ensaio piloto, que pode ser ampliado em outro estudo, a fim de verificar se os achados na literatura coincidiam com aqueles vivenciados por tradutores experientes e com nível superior. Os resultados apontam para a necessidade da ampliação dos cursos de formação inicial e continuada do tradutor e intérprete, exigência de formação universitária nos editais de concurso, melhora dos salários e adequação das funções de modo a não haver sobreposição com o trabalho do professor ou ser dele um substituto, contexto esse que aumenta os riscos de adoecimento laboral.
Genetic diversity based on morphological traits and germplasm conservation of walnut in Kashmir, Pakistan
Authors: Swati Javaid Qayyoom , Khan Muhammad Q. , Butt Iqball , Azhar Nosheen
Published: November 2021

Persian walnut is an economically important nut crop of temperate regions of the world. In the present study 225 local walnut accessions from 37 sites of Azad Jammu and Kashmir were analysed for morphological traits to investigate variability and identify superior one. Nut length, nut weight, shell thickness and nut diameter varied from 20.87–47.34 mm, 6.44–17.7 g, 1.61–2.54 mm and 27.25–44.31 mm respectively. Kernel weight and percentage varied from 2.81–8.65 g and 32.53–77.34%. Data were analysed statistically using multivariate analysis such as Principal Components Analysis and Cluster Analysis. Pearson correlation coefficient among traits revealed a positively significant correlation between nut weight and nut thickness (r = 0.45987), kernel weight and nut weight (r = 0.94777), kernel% and nut thickness (r = 0.48346), shell thickness and kernel% (r = 0.21961), a negative correlation with significant differences was found between kernel weight and nut thickness (r = –0.40968), kernel% and nut length (r = –0.10844) and between kernel% and nut weight (r = –0.95209). The highest and most significant positive correlation (0.96024) was observed between kernel weight and kernel% and (r = 0.94777) between kernel weight and nut weight. A wide range of variability was observed among walnut accessions and BA2, BN2, CN3 and BN4 accessions are reported as superior and conserved for future breeding programs due to their distinct characteristics.
The influence of exogenous gibberellic acid (GA3) and 24-epibrassinolide (24-EpiBL) on seed germination and the expression of genes involved in GA and BR synthesis/signalling in pepper (Capsicum annuum L.)
Authors: Çayan Selin , Sarıkamış Gölge , Yüksel Özmen Canan , Kibar Umut , Özden Eren , Ergül Ali
Published: November 2021

Gibberellins (GAs) and brassinosteroids (BRs) are the plant hormones involved in various physiological processes including seed germination. In this study, the effects of exogenous gibberellic acid (GA3) and 24-epibrassinolide (24-EpiBL) treatments on the expression of key genes involved in GA and BR syntheis/signalling during seed germination were investigated in pepper (Capsicum annuum L).

The expressions of BES1 and BRI1 involved in BR synthesis/signalling pathway as well as GA3OX1 and GA20OX1 associated with gibberellic acid biosynthesis in plants were determined. Exogenous GA3 treatments increased BES1 expression and the highest increase was determined with 10⁻⁸ M BR + 100 µM GA3 (P<0.05).  On the contrary, the expression of BRI1 gene was significantly decreased by 10-8 M BR + 100 µM GA3 (P<0.05). The expression of GA3OX1 gene was induced with BR and GA3 treatments (P<0.05). GA20OX1 gene expression was generally higher compared to the expression of GA3OX1 and significantly increased by the GA3 treatments. Our findings are expected to bring an insight to the influence of BRs during seed germination together with the expression of associated genes.
Nutritional value, bioactive compounds and capacity antioxidant in edible flowers of dahlia
Authors: Martínez-Damián María Teresa , Mejía-Muñoz José Merced , Colinas-León María Teresa , Hernández-Epigmenio Francisca , Cruz-Alvarez Oscar
Published: November 2021

The aim of this research was to evaluate the nutritional value, bioactive compounds and capacity antioxidant in ligulate flowers of dahlia with different colour. The statistical analysis reveals that the petals of the pink and purple colour have more protein and raw fibre (18.54 and 19.25, 16.54 and 15.81%, respectively) and similar raw fat values between the analysed colours. Likewise, the flowers with the highest content of vitamin C, phenols and total flavonoids were observed in the pink, purple and cherry colours, where the latter also stands out for its content of total anthocyanins (3.2 mg cyanidin-3-glucoside 100 g–1). However, the yellow ones showed higher antioxidant capacity (68.82 mg AAEVC 100 g–1), which coincides with that found with the concentration of total carotenoids (0.64 μg β-carotene g–1). For the consumers who choose to change their eating habits and seek to include ingredients of vegetable origin (vegetarian and vegan) with low caloric content and a sufficient