bluuebunny/crossref_metadata_2025 huggingface dataset:
Coagulation and complement system in critically ill patients
Authors: Helling H. , Stephan B. , Pindur G.
Published: November 2015

Activation of coagulation and inflammatory response including the complement system play a major role in the pathogenesis of critical illness. However, only limited data are available addressing the relationship of both pathways and its assessment of a predictive value for the clinical outcome in intense care medicine. Therefore, parameters of the coagulation and complement system were studied in patients with septicaemia and multiple trauma regarded as being exemplary for critical illness. 34 patients (mean age: 51.38 years (±16.57), 15 females, 19 males) were investigated at day 1 of admittance to the intensive care unit (ICU). Leukocytes, complement factors C3a and C5a were significantly ( p <  0.0500) higher in sepsis than in trauma, whereas platelet count and plasma fibrinogen were significantly lower in multiple trauma. Activation markers of coagulation were elevated in both groups, however, thrombin-antithrombin-complex was significantly higher in multiple trauma. DIC scores of 5 were not exceeded in any of the two groups. Analysing the influences on mortality (11/34; 32.35% ), which was not different in both groups, non-survivors were significantly older, had significantly higher multiple organ failure (MOF) scores, lactate, abnormal prothrombin times and lower C1-inhibitor activities, even more pronounced in early deaths, than survivors. In septic non-survivors protein C was significantly lower than in trauma. We conclude from these data that activation of the complement system as part of the inflammatory response is a significant mechanism in septicaemia, whereas loss and consumption of blood components including parts of the coagulation and complement system is more characteristic for multiple trauma. Protein C in case of severe reduction might be of special concern for surviving in sepsis. Activation of haemostasis was occurring in both diseases, however, overt DIC was not confirmed in this study to be a leading mechanism in critically ill patients. MOF score, lactate, C1-inhibitor and prothrombin time have been the only statistically significant predictors for lethal outcome suggesting that organ function, microcirculation, haemostasis and inflammatory response are essential elements of the pathomechanism and clinical course of diseases among critically ill patients.
Shell matters: Magnetic targeting of SPIONs and in vitro effects on endothelial and monocytic cell function
Authors: Matuszak Jasmin , Dörfler Philipp , Zaloga Jan , Unterweger Harald , Lyer Stefan , Dietel Barbara , Alexiou Christoph , Cicha Iwona
Published: November 2015

Superparamagnetic iron oxide nanoparticles (SPIONs) are versatile and easily functionalized agents with high potential for diagnostic and therapeutic intravascular applications. In this study, we analyzed the responses of endothelial (ECs) and monocytic cells to three different types of SPIONs, in order to assess the influence of physico-chemical properties on the biological reactions to SPIONs. The following formulations were used: (1) Lauric acid-coated and BSA-stabilized SPION-1,(2) Lauric acid/BSA-coated SPION-2 and (3) dextran-coated SPION-3. SPION-1 were strongly internalized by ECs and reduced their viability in static conditions. Additionally, they had a dose-dependent inhibitory effect on monocytic cell chemotaxis to MCP-1, but did not affect monocytic cell recruitment by ECs. SPION-2 uptake was less pronounced, both in ECs and monocytic cells, and these particles were better tolerated by the vascular cells. Not being internalized by endothelial or monocytic cells, SPION-3 did not induce relevant effects on cell viability, motility or endothelial-monocytic cell interactions.

Taken together, localized accumulation of circulating SPION under physiologic-like flow conditions and their cellular uptake depends on the physicochemical characteristics. Our findings suggest that SPION-2 are suitable for magnetic targeting of atherosclerotic plaques. Due to their excellent biocompatibility and low internalization, SPION-3 may represent a suitable imaging agent for intravascular applications.
Determining cut-off points in functional assessment scales in stroke
Authors: Balasch i Bernat Mercè , Balasch i Parisi Sebastiá , Sebastián Enrique Noé , Moscardó Lirios Dueñas , Ferri Campos Joan , López Bueno Laura
Published: November 2015

BACKGROUND:

A wide variety of well-validated assessment scales of functioning and disability have been developed for stroke population. However, these instruments have limitations in their interpretation. Therefore, determining cut-off points for their categorization becomes necessary.

OBJECTIVES:

To determine cut-off points for the BI, FIM and FAM scales to differentiate clinical disability categories and to establish the relationship between mRS and DOS scales.

METHODS:

One hundred and six adults with ischemic or haemorrhagic stroke were mainly recruited from a rehabilitation facility (Hospitales Nisa, Valencia, Spain).

RESULTS:

A high correlation was observed between the DOS and mRS scales (Kendall’s tau-b = 0.475; p = 0.000) although a certain amount of disagreement between the two scales was detected. The cut-off points were 62.90 (95% CI, 57.26–69.29) and 21.30 (95% CI, 16.34–26.03) for the BI; 70.62 (95% CI, 66.65–75.22) and 38.29 (95% CI, 34.07–42.25) for the FIM; and 116.07 (95% CI, 110.30–122.68) and 66.02 (95% CI, 59.20–72.35) for the FAM.

CONCLUSION(S):

DOS was observed to be more demanding than the mRS, in terms of patient independence. Additionally, the lower cut-off points separating the levels of severe and moderate disability in the BI, FIM and FAM were determined. These findings would facilitate practitioners clinical interpretation of disability levels in post-stroke patients.
Comparison between treadmill training with rhythmic auditory stimulation and ground walking with rhythmic auditory stimulation on gait ability in chronic stroke patients: A pilot study
Authors: Park Jin , Park So-yeon , Kim Yong-wook , Woo Youngkeun
Published: November 2015

BACKGROUND:

Generally, treadmill training is very effective intervention, and rhythmic auditory stimulation is designed to feedback during gait training in stroke patients.

OBJECTIVE:

The purpose of this study was to compare the gait abilities in chronic stroke patients following either treadmill walking training with rhythmic auditory stimulation (TRAS) or over ground walking training with rhythmic auditory stimulation (ORAS).

METHODS:

Nineteen subjects were divided into two groups: a TRAS group (9 subjects) and an ORAS group (10 subjects). Temporal and spatial gait parameters and motor recovery ability were measured before and after the training period. Gait ability was measured by the Biodex Gait trainer treadmill system, Timed up and go test (TUG), 6 meter walking distance (6MWD) and Functional gait assessment (FGA).

RESULTS:

After the training periods, the TRAS group showed a significant improvement in walking speed, step cycle, step length of the unaffected limb, coefficient of variation, 6MWD, and, FGA when compared to the ORAS group ( p <  0.05).

CONCLUSION:

Treadmill walking training during the rhythmic auditory stimulation may be useful for rehabilitation of patients with chronic stroke.
Efficacy of exercise intervention programs on cognition in people suffering from multiple sclerosis, stroke and Parkinson’s disease: A systematic review and meta-analysis of current evidence
Authors: Kalron Alon , Zeilig Gabi
Published: November 2015

BACKGROUND:

Cognitive impairment is a well-established sequela of people suffering from neurological pathologies.

OBJECTIVE:

To examine the effects of exercise intervention programs on cognitive performance in participants suffering from stroke, multiple sclerosis and Parkinson’s disease.

METHODS:

Four online databases (CINAHL, Cochrane Library, MEDLINE, PEDro) were comprehensively searched from their inception through December 2014. The search query was phrased as follows: In people suffering from MS, stroke or Parkinson’s disease, do exercise intervention programs improve cognitive performance?

RESULTS:

Twelve controlled clinical trials met our inclusion criteria. Studies were classified according to three clinical subgroups: Parkinson’s disease ( n = 3), stroke ( n = 1) and multiple sclerosis ( n = 8). Eight studies employed an aerobic intervention program; one used an active exercise program based on virtual reality systems, three reports examined the effect of yoga and one compared the intervention program with sport climbing. Significant improvements in cognition were found in nine out of the twelve studies. Nevertheless, the total effect size was non-significant (0.18 (95% CI, – 4.1, 3.8)) for changes in executive functions.

CONCLUSION:

Due to lack of commonality between measures of cognition, training sequences and intervention period, it remains unclear as to whether exercise training can be effective in improving the cognitive functions of neurological patients.
Phytochemical investigation GC-MS analysis and in vitro antimicrobial activity of Coleus forskohlii
Authors: Rajkumar Krishnamoorthy , Malathi Ramaswamy
Published: November 2015

The aim of this study was to investigate the phytochemical constituents, gas chromatography-mass spectrometry (GC-MS) analysis and antimicrobial activity of Coleus forskohlii. The different solvents such as ethanol, chloroform, acetone and aqueous extracts were identified pharmacologically as important bioactive compounds and their antimicrobial properties were studied. In the phytochemical investigation almost all the ethanol extract of leaf, stem and root having secondary metabolites like alkaloids, flavonoids, tannins, saponins, terpenoids, and steroids. The active constituents of the ethanol extract of C. forskohlii root was studied by GC-MS analysis. According to the antimicrobial results ethanol extract of C. froshkolii root showed highest antibacterial activity compared with stem and leaf. The highest antimicrobial activity was observed against Klebsiella pneumonia (19 mm) and Candida albicans (16 mm) in ethanol extract of root. Among the above extracts of leaf, stem and root, ethanol extract of root having antimicrobial activities due to the presence of phytoconstituents.

 
Acoustic Radiation by 3D Vortex Rings in Air
Authors: Shugaev Fedor , Cherkasov Dmitri , Solenaya Oxana
Published: November 2015

Acoustic radiation emitted by three-dimensional (3D) vortex rings in air has been investigated on the basis of the unsteady Navier–Stokes equations. Power series expansions of the unknown functions with respect to the initial vorticity which is supposed to be small are used. In such a manner the system of the Navier–Stokes equations is reduced to a parabolic system with constant coefficients at high derivatives. The initial value problem is as follows. The vorticity is defined inside a toroid at t = 0. Other gas parameters are assumed to be constant throughout the whole space at t = 0. The solution is expressed by multiple integrals which are evaluated with the aid of the Korobov grids. Density oscillations are analyzed. The results show that the frequency band depends on the initial size of the vortex ring and its helicity. The presented data may be applied to the study of a flow in a wake region behind an aerodynamic body.
Skin Immunization Obviates Alcohol-Related Immune Dysfunction
Authors: Brand Rhonda , Stottlemyer John , Cline Rachel , Donahue Cara , Behari Jaideep , Falo Jr. Louis
Published: November 2015

Alcoholics suffer from immune dysfunction that can impede vaccine efficacy. If ethanol (EtOH)-induced immune impairment is in part a result of direct exposure of immune cells to EtOH, then reduced levels of exposure could result in less immune dysfunction. As alcohol ingestion results in lower alcohol levels in skin than blood, we hypothesized that the skin immune network may be relatively preserved, enabling skin-targeted immunizations to obviate the immune inhibitory effects of alcohol consumption on conventional vaccines. We employed the two most common chronic EtOH mouse feeding models, the liver-damaging Lieber-DeCarli (LD) and liver-sparing Meadows-Cook (MC) diets, to examine the roles of EtOH and/or EtOH-induced liver dysfunction on alcohol related immunosuppression. Pair-fed mice were immunized against the model antigen ovalbumin (OVA) by DNA immunization or against flu by administering the protein-based influenza vaccine either systemically (IV, IM), directly to liver (hydrodynamic), or cutaneously (biolistic, ID). We measured resulting tissue EtOH levels, liver stress, regulatory T cell (Treg), and myeloid-derived suppressor cell (MDSC) populations. We compared immune responsiveness by measuring delayed-type hypersensitivity (DTH), antigen-specific cytotoxic T lymphocyte (CTL), and antibody induction as a function of delivery route and feeding model. We found that, as expected, and independent of the feeding model, EtOH ingestion inhibits DTH, CTL lysis, and antigen-specific total IgG induced by traditional systemic vaccines. On the other hand, skin-targeted vaccines were equally immunogenic in alcohol-exposed and non-exposed subjects, suggesting that cutaneous immunization may result in more efficacious vaccination in alcohol-ingesting subjects.
The Classification of Hysteria and Related Disorders: Historical and Phenomenological Considerations
Authors: North Carol
Published: November 2015

This article examines the history of the conceptualization of dissociative, conversion, and somatoform syndromes in relation to one another, chronicles efforts to classify these and other phenomenologically-related psychopathology in the American diagnostic system for mental disorders, and traces the subsequent divergence in opinions of dissenting sectors on classification of these disorders. This article then considers the extensive phenomenological overlap across these disorders in empirical research, and from this foundation presents a new model for the conceptualization of these disorders. The classification of disorders formerly known as hysteria and phenomenologically-related syndromes has long been contentious and unsettled. Examination of the long history of the conceptual difficulties, which remain inherent in existing classification schemes for these disorders, can help to address the continuing controversy. This review clarifies the need for a major conceptual revision of the current classification of these disorders. A new phenomenologically-based classification scheme for these disorders is proposed that is more compatible with the agnostic and atheoretical approach to diagnosis of mental disorders used by the current classification system.
Thermoelectric Properties of Alumina-Doped Bi0.4Sb1.6Te3 Nanocomposites Prepared through Mechanical Alloying and Vacuum Hot Pressing
Authors: Lin Chung-Kwei , Chen May-Show , Huang Rong-Tan , Cheng Yu-Chun , Lee Pee-Yew
Published: November 2015

In this study, γ-Al2O3 particles were dispersed in p-type Bi0.4Sb1.6Te3 through mechanical alloying to form γ-Al2O3/Bi0.4Sb1.6Te3 composite powders. The composite powders were consolidated using vacuum hot pressing to produce nano- and microstructured composites. Thermoelectric (TE) measurements indicated that adding an optimal amount of γ-Al2O3 nanoparticles improves the TE performance of the fabricated composites. High TE performances with figure of merit (ZT) values as high as 1.22 and 1.21 were achieved at 373 and 398 K for samples containing 1 and 3 wt % γ-Al2O3 nanoparticles, respectively. These ZT values are higher than those of monolithic Bi0.4Sb1.6Te3 samples. The ZT values of the fabricated samples at 298–423 K are 1.0–1.22; these ZT characteristics make γ-Al2O3/Bi0.4Sb1.6Te3 composites suitable for power generation applications because no other material with a similarly high ZT value has been reported at this temperature range. The achieved high ZT value may be attributable to the unique nano- and microstructures in which γ-Al2O3 nanoparticles are dispersed among the grain boundary or in the matrix grain, as revealed by high-resolution transmission electron microscopy. The dispersed γ-Al2O3 nanoparticles thus increase phonon scattering sites and reduce thermal conductivity. The results indicated that the nano- and microstructured γ-Al2O3/Bi0.4Sb1.6Te3 alloy can serve as a high-performance material for application in TE devices.
The Influence of Non-Uniform High Heat Flux on Thermal Stress of Thermoelectric Power Generator
Authors: Ming Tingzhen , Wang Qiankun , Peng Keyuan , Cai Zhe , Yang Wei , Wu Yongjia , Gong Tingrui
Published: November 2015

A thermoelectric generator (TEG) device which uses solar energy as heat source would achieve higher efficiency if there is a higher temperature difference between the hot-cold ends. However, higher temperature or higher heat flux being imposed upon the hot end will cause strong thermal stress, which will have a negative influence on the life cycle of the thermoelectric module. Meanwhile, in order to get high heat flux, a Fresnel lens is required to concentrate solar energy, which will cause non-uniformity of heat flux on the hot end of the TEG and further influence the thermal stress of the device. This phenomenon is very common in solar TEG devices but seldom research work has been reported. In this paper, numerical analysis on the heat transfer and thermal stress performance of a TEG module has been performed considering the variation on the power of the heat flux being imposed upon the hot-end; the influence of non-uniform high heat flux on thermal stress has also been analyzed. It is found that non-uniformity of high heat flux being imposed upon the hot end has a significant effect on the thermal stress of TEG and life expectation of the device. Taking the uniformity of 100% as standard, when the heating uniformity is 70%, 50%, 30%, and 10%, respectively, the maximum thermal stress of TEG module increased by 3%, 6%, 12%, and 22% respectively. If we increase the heat flux on the hot end, the influence of non-uniformity on the thermal stress will be more remarkable.
Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach
Authors: Forini Francesca , Ucciferri Nadia , Kusmic Claudia , Nicolini Giuseppina , Cecchettini Antonella , Rocchiccioli Silvia , Citti Lorenzo , Iervasi Giorgio
Published: November 2015

Mitochondria are major determinants of cell fate in ischemia/reperfusion injury (IR) and common effectors of cardio-protective strategies in cardiac ischemic disease. Thyroid hormone homeostasis critically affects mitochondrial function and energy production. Since a low T3 state (LT3S) is frequently observed in the post infarction setting, the study was aimed to investigate the relationship between 72 h post IR T3 levels and both the cardiac function and the mitochondrial proteome in a rat model of IR. The low T3 group exhibits the most compromised cardiac performance along with the worst mitochondrial activity. Accordingly, our results show a different remodeling of the mitochondrial proteome in the presence or absence of a LT3S, with alterations in groups of proteins that play a key role in energy metabolism, quality control and regulation of cell death pathways. Overall, our findings highlight a relationship between LT3S in the early post IR and poor cardiac and mitochondrial outcomes, and suggest a potential implication of thyroid hormone in the cardio-protection and tissue remodeling in ischemic disease.
Metabolic Profiling of Pyrrolizidine Alkaloids in Foliage of Two Echium spp. Invaders in Australia—A Case of Novel Weapons?
Authors: Skoneczny Dominik , Weston Paul , Zhu Xiaocheng , Gurr Geoff , Callaway Ragan , Weston Leslie
Published: November 2015

Metabolic profiling allows for simultaneous and rapid annotation of biochemically similar organismal metabolites. An effective platform for profiling of toxic pyrrolizidine alkaloids (PAs) and their N-oxides (PANOs) was developed using ultra high pressure liquid chromatography quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry. Field-collected populations of invasive Australian weeds, Echium plantagineum and E. vulgare were raised under controlled glasshouse conditions and surveyed for the presence of related PAs and PANOs in leaf tissues at various growth stages. Echium plantagineum possessed numerous related and abundant PANOs (>17) by seven days following seed germination, and these were also observed in rosette and flowering growth stages. In contrast, the less invasive E. vulgare accumulated significantly lower levels of most PANOs under identical glasshouse conditions. Several previously unreported PAs were also found at trace levels. Field-grown populations of both species were also evaluated for PA production and highly toxic echimidine N-oxide was amongst the most abundant PANOs in foliage of both species. PAs in field and glasshouse plants were more abundant in the more widely invasive species, E. plantagineum, and may provide competitive advantage by increasing the plant’s capacity to deter natural enemies in its invaded range through production of novel weapons.
The Effect of Alendronate Loaded Biphasic Calcium Phosphate Scaffolds on Bone Regeneration in a Rat Tibial Defect Model
Authors: Park Kwang-Won , Yun Young-Pil , Kim Sung , Song Hae-Ryong
Published: November 2015

This study investigated the effect of alendronate (Aln) released from biphasic calcium phosphate (BCP) scaffolds. We evaluated the in vitro osteogenic differentiation of Aln/BCP scaffolds using MG-63 cells and the in vivo bone regenerative capability of Aln/BCP scaffolds using a rat tibial defect model with radiography, micro-computed tomography (CT), and histological examination. In vitro studies included the surface morphology of BCP and Aln-loaded BCP scaffolds visualized using field-emission scanning electron microscope, release kinetics of Aln from BCP scaffolds, alkaline phosphatase (ALP) activity, calcium deposition, and gene expression. The in vitro studies showed that sustained release of Aln from the BCP scaffolds consisted of porous microstructures, and revealed that MG-63 cells cultured on Aln-loaded BCP scaffolds showed significantly increased ALP activity, calcium deposition, and gene expression compared to cells cultured on BCP scaffolds. The in vivo studies using radiograph and histology examination revealed abundant callus formation and bone maturation at the site in the Aln/BCP groups compared to the control group. However, solid bony bridge formation was not observed at plain radiographs until 8 weeks. Micro-CT analysis revealed that bone mineral density and bone formation volume were increased over time in an Aln concentration-dependent manner. These results suggested that Aln/BCP scaffolds have the potential for controlling the release of Aln and enhance bone formation and mineralization.
Mycophenolate Mofetil Modulates Differentiation of Th1/Th2 and the Secretion of Cytokines in an Active Crohn’s Disease Mouse Model
Authors: Lv Qing-Kang , Liu Ju-Xiong , Li Su-Nan , Gao Ying-Jie , Lv Yan , Xu Zi-Peng , Huang Bing-Xu , Xu Shi-Yao , Yang Dong-Xue , Zeng Ya-Long , Liu Dian-Feng , Wang Wei
Published: November 2015

Mycophenolate mofetil (MMF) is an alternative immunosuppressive agent that has been reported to be effective and well tolerated for the treatment of refractory inflammatory bowel disease (IBD). The aim of this study was to investigate the therapeutic effect of MMF on intestinal injury and tissue inflammation, which were caused by Crohn’s disease (CD). Here, trinitrobenzene sulfonic acid-relapsing (TNBS) colitis was induced in mice; then, we measured the differentiation of Th1/Th2 cells in mouse splenocytes by flow cytometry and the secretion of cytokines in mice with TNBS-induced colitis by real-time polymerase chain reaction and/or enzyme-linked immunosorbent assay (RT-PCR/ELISA). The results show that MMF significantly inhibited mRNA expression of pro-inflammatory cytokines IFN-γ, TNF-α, IL-12, IL-6, and IL-1β in mice with TNBS-induced colitis; however, MMF did not inhibit the expression of IL-10 mRNA. Additionally, ELISA showed that the serum levels of IFN-γ, TNF-α, IL-12, IL-6, and IL-1β were down-regulated in a TNBS model of colitis. Flow cytometric analysis showed MMF markedly reduced the percentages of Th1 and Th2 splenocytes in the CD mouse model. Mycophenolic acid (MPA) also significantly decreased the percentages of splenic Th1 and Th2 cells in vitro. Furthermore, MMF treatment not only significantly ameliorated diarrhea, and loss of body weight but also abrogated the histopathologic severity and inflammatory response of inflammatory colitis, and increased the survival rate of TNBS-induced colitic mice. These results suggest that treatment with MMF may improve experimental colitis and induce inflammatory response remission of CD by down-regulation of pro-inflammatory cytokines via modulation of the differentiation of Th1/Th2 cells.
Design Optimization for a Truncated Catenary Mooring System for Scale Model Test
Authors: Molins Climent , Trubat Pau , Gironella Xavi , Campos Alexis
Published: November 2015

One of the main aspects when testing floating offshore platforms is the scaled mooring system, particularly with the increased depths where such platforms are intended. The paper proposes the use of truncated mooring systems to emulate the real mooring system by solving an optimization problem. This approach could be an interesting option when the existing testing facilities do not have enough available space. As part of the development of a new spar platform made of concrete for Floating Offshore Wind Turbines (FOWTs), called Windcrete, a station keeping system with catenary shaped lines was selected. The test facility available for the planned experiments had an important width constraint. Then, an algorithm to optimize the design of the scaled truncated mooring system using different weights of lines was developed. The optimization process adjusts the quasi-static behavior of the scaled mooring system as much as possible to the real mooring system within its expected maximum displacement range, where the catenary line provides the restoring forces by its suspended line length.
Enhanced Stability of Calcium Sulfate Scaffolds with 45S5 Bioglass for Bone Repair
Authors: Shuai Cijun , Zhou Jianhua , Wu Ping , Gao Chengde , Feng Pei , Xiao Tao , Deng Youwen , Peng Shuping
Published: November 2015

Calcium sulfate (CaSO4), as a promising tissue repair material, has been applied widely due to its outstanding bioabsorbability and osteoconduction. However, fast disintegration, insufficient mechanical strength and poor bioactivity have limited its further application. In the study, CaSO4 scaffolds fabricated by using selective laser sintering were improved by adding 45S5 bioglass. The 45S5 bioglass enhanced stability significantly due to the bond effect of glassy phase between the CaSO4 grains. After immersing for four days in simulated body fluid (SBF), the specimens with 45S5 bioglass could still retain its original shape compared as opposed to specimens without 45S5 bioglass who experienced disintegration. Meanwhile, its compressive strength and fracture toughness increased by 80% and 37%, respectively. Furthermore, the apatite layer was formed on the CaSO4 scaffolds with 45S5 bioglass in SBF, indicating good bioactivity of the scaffolds. In addition, the scaffolds showed good ability to support the osteoblast-like cell adhesion and proliferation.
Iron, Aging, and Neurodegeneration
Authors: Angelova Dafina , Brown David
Published: November 2015

Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the irreplaceable nature of neurons. In this regard regulation of brain iron chemistry is essential to maintaining neuronal viability. During the course of normal aging, the brain changes the way it deals with iron and this can contribute to its susceptibility to disease. Additionally, many of the known neurodegenerative diseases have been shown to be influenced by changes in brain iron. This review examines the role of iron in the brain and neurodegenerative diseases and the potential role of changes in brain iron caused by aging.
The Potential of the Yeast Debaryomyces hansenii H525 to Degrade Biogenic Amines in Food
Authors: Bäumlisberger Mathias , Moellecken Urs , König Helmut , Claus Harald
Published: November 2015

Twenty-six yeasts from different genera were investigated for their ability to metabolize biogenic amines. About half of the yeast strains produced one or more different biogenic amines, but some strains of Debaryomyces hansenii and Yarrowia lipolytica were also able to degrade such compounds. The most effective strain D. hanseniii H525 metabolized a broad spectrum of biogenic amines by growing and resting cells. Degradation of biogenic amines by this yeast isolate could be attributed to a peroxisomal amine oxidase activity. Strain H525 may be useful as a starter culture to reduce biogenic amines in fermented food.
Nanoporous Carbon Nanofibers Decorated with Platinum Nanoparticles for Non-Enzymatic Electrochemical Sensing of H2O2
Authors: Li Yang , Zhang Mingfa , Zhang Xiaopeng , Xie Guocheng , Su Zhiqiang , Wei Gang
Published: November 2015

We describe the preparation of nanoporous carbon nanofibers (CNFs) decorated with platinum nanoparticles (PtNPs) in this work by electrospining polyacrylonitrile (PAN) nanofibers and subsequent carbonization and binding of PtNPs. The fabricated nanoporous CNF-PtNP hybrids were further utilized to modify glass carbon electrodes and used for the non-enzymatic amperometric biosensor for the highly sensitive detection of hydrogen peroxide (H2O2). The morphologies of the fabricated nanoporous CNF-PtNP hybrids were observed by scanning electron microscopy, transmission electron microscopy, and their structure was further investigated with Brunauer–Emmett–Teller (BET) surface area analysis, X-ray photoelectron spectroscopy, X-ray diffraction, and Raman spectrum. The cyclic voltammetry experiments indicate that CNF-PtNP modified electrodes have high electrocatalytic activity toward H2O2 and the chronoamperometry measurements illustrate that the fabricated biosensor has a high sensitivity for detecting H2O2. We anticipate that the strategies utilized in this work will not only guide the further design and fabrication of functional nanofiber-based biomaterials and nanodevices, but also extend the potential applications in energy storage, cytology, and tissue engineering.
Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
Authors: Grandone Anna , Marzuillo Pierluigi , Perrone Laura , Del Giudice Emanuele
Published: November 2015

Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connecting mechanism, however, is not completely known. This review is focused on: (1) iron deficiency in obese children and the role of hepcidin in the connection between body fat and poor iron status; (2) iron status and consequences on health, in particular on cognitive function; (3) cognitive function and obesity; (4) suggestion of a possible link between cognitive dysfunction and ID in pediatric obesity; and implications for therapy and future research.
A Thermally Tunable 1 × 4 Channel Wavelength Demultiplexer Designed on a Low-Loss Si3N4 Waveguide Platform
Authors: Hai Mohammed , Leinse Arne , Veenstra Theo , Liboiron-Ladouceur Odile
Published: November 2015

A thermally tunable 1 × 4 channel optical demultiplexer was designed using an ultra low-loss Si3N4 (propagation loss ~3.1 dB/m) waveguide. The demultiplexer has three 2 × 2 Mach-Zehnder interferometers (MZI), where each of the MZI contains two 2 × 2 general interference based multimode interference (MMI) couplers. The MMI couplers exhibit −3.3 dB to −3.7 dB power division ratios over a 50 nm wavelength range from 1530 nm to 1580 nm. The chrome-based (Cr) heaters placed on the delay arms of the MZI filters enable thermal tuning to control the optical phase shift in the MZI delay arms. This facilitates achieving moderately low crosstalk (14.5 dB) between the adjacent channels. The optical insertion loss of the demultiplexer per channel is between 1.5 dB to 2.2 dB over the 1550 nm to 1565 nm wavelength range. Error free performance (BER of 10−12) is obtained for all four 40 Gb/s data rate channels. The optical demultiplexer is an important tool towards building photonic integrated circuits with complex optical signal processing functionalities in the low-loss Si3N4 waveguide platform.
Hyperspectral Differentiation of Phytoplankton Taxonomic Groups: A Comparison between Using Remote Sensing Reflectance and Absorption Spectra
Authors: Xi Hongyan , Hieronymi Martin , Röttgers Rüdiger , Krasemann Hajo , Qiu Zhongfeng
Published: November 2015

The emergence of hyperspectral optical satellite sensors for ocean observation provides potential for more detailed information from aquatic ecosystems. The German hyperspectral satellite mission EnMAP (enmap.org) currently in the production phase is supported by a project to explore the capability of using EnMAP data and other future hyperspectral data from space. One task is to identify phytoplankton taxonomic groups. To fulfill this objective, on the basis of laboratory-measured absorption coefficients of phytoplankton cultures (aph(λ)) and corresponding simulated remote sensing reflectance spectra (Rrs(λ)), we examined the performance of spectral fourth-derivative analysis and clustering techniques to differentiate six taxonomic groups. We compared different sources of input data, namely aph(λ), Rrs(λ), and the absorption of water compounds obtained from inversion of the Rrs(λ)) spectra using a quasi-analytical algorithm (QAA). Rrs(λ) was tested as it can be directly obtained from hyperspectral sensors. The last one was tested as expected influences of the spectral features of pure water absorption on Rrs(λ) could be avoided after subtracting it from the inverted total absorption. Results showed that derivative analysis of measured aph(λ) spectra performed best with only a few misclassified cultures. Based on Rrs(λ) spectra, the accuracy of this differentiation decreased but the performance was partly restored if wavelengths of strong water absorption were excluded and chlorophyll concentrations were higher than 1 mg∙m−3. When based on QAA-inverted absorption spectra, the differentiation was less precise due to loss of information at longer wavelengths. This analysis showed that, compared to inverted absorption spectra from restricted inversion models, hyperspectral Rrs(λ) is potentially suitable input data for the differentiation of phytoplankton taxonomic groups in prospective EnMAP applications, though still a challenge at low algal concentrations.
Smartphone Application for the Analysis of Prosodic Features in Running Speech with a Focus on Bipolar Disorders: System Performance Evaluation and Case Study
Authors: Guidi Andrea , Salvi Sergio , Ottaviano Manuel , Gentili Claudio , Bertschy Gilles , De Rossi Danilo , Scilingo Enzo , Vanello Nicola
Published: November 2015

Bipolar disorder is one of the most common mood disorders characterized by large and invalidating mood swings. Several projects focus on the development of decision support systems that monitor and advise patients, as well as clinicians. Voice monitoring and speech signal analysis can be exploited to reach this goal. In this study, an Android application was designed for analyzing running speech using a smartphone device. The application can record audio samples and estimate speech fundamental frequency, F0, and its changes. F0-related features are estimated locally on the smartphone, with some advantages with respect to remote processing approaches in terms of privacy protection and reduced upload costs. The raw features can be sent to a central server and further processed. The quality of the audio recordings, algorithm reliability and performance of the overall system were evaluated in terms of voiced segment detection and features estimation. The results demonstrate that mean F0 from each voiced segment can be reliably estimated, thus describing prosodic features across the speech sample. Instead, features related to F0 variability within each voiced segment performed poorly. A case study performed on a bipolar patient is presented.
Quantitative Ethylene Measurements with MOx Chemiresistive Sensors at Different Relative Air Humidities
Authors: Krivec Matic , Gunnigle Gerald , Abram Anže , Maier Dieter , Waldner Roland , Gostner Johanna , Überall Florian , Leitner Raimund
Published: November 2015

The sensitivity of two commercial metal oxide (MOx) sensors to ethylene is tested at different relative humidities. One sensor (MiCS-5914) is based on tungsten oxide, the other (MQ-3) on tin oxide. Both sensors were found to be sensitive to ethylene concentrations down to 10 ppm. Both sensors have significant response times; however, the tungsten sensor is the faster one. Sensor models are developed that predict the concentration of ethylene given the sensor output and the relative humidity. The MQ-3 sensor model achieves an accuracy of ±9.2 ppm and the MiCS-5914 sensor model predicts concentration to ±7.0 ppm. Both sensors are more accurate for concentrations below 50 ppm, achieving ±6.7 ppm (MQ-3) and 5.7 ppm (MiCS-5914).
Frequency-Switchable Metamaterial Absorber Injecting Eutectic Gallium-Indium (EGaIn) Liquid Metal Alloy
Authors: Ling Kenyu , Kim Hyung , Yoo Minyeong , Lim Sungjoon
Published: November 2015

In this study, we demonstrated a new class of frequency-switchable metamaterial absorber in the X-band. Eutectic gallium-indium (EGaIn), a liquid metal alloy, was injected in a microfluidic channel engraved on polymethyl methacrylate (PMMA) to achieve frequency switching. Numerical simulation and experimental results are presented for two cases: when the microfluidic channels are empty, and when they are filled with liquid metal. To evaluate the performance of the fabricated absorber prototype, it is tested with a rectangular waveguide. The resonant frequency was successfully switched from 10.96 GHz to 10.61 GHz after injecting liquid metal while maintaining absorptivity higher than 98%.
The Synthesis and Anion Recognition Property of Symmetrical Chemosensors Involving Thiourea Groups: Theory and Experiments
Authors: Shang Xuefang , Yang Zhenhua , Fu Jiajia , Zhao Peipei , Xu Xiufang
Published: November 2015

The synthesis of four symmetrical compounds containing urea/thiourea and anthracene/nitrobenzene groups was optimized. N,N’-Di((anthracen-9-yl)-methylene) thio-carbonohydrazide showed sensitive and selective binding ability for acetate ion among the studied anions. The presence of other competitive anions including F−, H2PO4−, Cl−, Br− and I− did not interfere with the strong binding ability. The mechanism of the host-guest interaction was through multiple hydrogen bonds due to the conformational complementarity and higher basicity. A theoretical investigation explained that intra-molecular hydrogen bonds existed in the compound which could strengthen the anion binding ability. In addition, molecular frontier orbitals in molecular interplay were introduced in order to explain the red-shift phenomenon in the host-guest interaction process. Compounds based on thiourea and anthracene derivatives can thus be used as a chemosensor for detecting acetate ion in environmental and pharmaceutical samples.
PMHT Approach for Multi-Target Multi-Sensor Sonar Tracking in Clutter
Authors: Li Xiaohua , Li Yaan , Yu Jing , Chen Xiao , Dai Miao
Published: November 2015

Multi-sensor sonar tracking has many advantages, such as the potential to reduce the overall measurement uncertainty and the possibility to hide the receiver. However, the use of multi-target multi-sensor sonar tracking is challenging because of the complexity of the underwater environment, especially the low target detection probability and extremely large number of false alarms caused by reverberation. In this work, to solve the problem of multi-target multi-sensor sonar tracking in the presence of clutter, a novel probabilistic multi-hypothesis tracker (PMHT) approach based on the extended Kalman filter (EKF) and unscented Kalman filter (UKF) is proposed. The PMHT can efficiently handle the unknown measurements-to-targets and measurements-to-transmitters data association ambiguity. The EKF and UKF are used to deal with the high degree of nonlinearity in the measurement model. The simulation results show that the proposed algorithm can improve the target tracking performance in a cluttered environment greatly, and its computational load is low.
Multi-Agent Modeling and Simulation of Farmland Use Change in a Farming–Pastoral Zone: A Case Study of Qianjingou Town in Inner Mongolia, China
Authors: Bai Xuehong , Yan Huimin , Pan Lihu , Huang He
Published: November 2015

Farmland is the most basic material condition for guaranteeing rural livelihoods and national food security, and exploring management strategies that take both stable rural livelihoods and sustainable farmland use into account has vital significance in theory and practice. Farmland is a complex and self-adaptive system that couples human and natural systems, and natural and social factors that are related to its changing process need to be considered when modeling farmland changing processes. This paper uses Qianjingou Town in the Inner Mongolian farming–pastoral zone as a study area. From the perspective of the relationship between household livelihood and farmland use, this study establishes the process mechanism of farmland use change based on questionnaire data, and constructs a multi-agent simulation model of farmland use change using the Eclipse and Repast toolbox. Through simulating the relationship between natural factors (including geographical location) and household behavior, this paper systematically simulates household farmland abandonment and rent behaviors, and accurately describes the dynamic interactions between household livelihoods and the factors related to farmland use change. These factors include natural factors (net primary productivity, road accessibility, slope and relief amplitude) and social factors (household family structures, economic development and government policies). Ultimately, this study scientifically predicts the future farmland use change trend in the next 30 years. The simulation results show that the number of abandoned and sublet farmland plots has a gradually increasing trend, and the number of non-farming households and pure-outworking households has a remarkable increasing trend, whereas the number of part-farming households and pure-farming households has a decreasing trend. Household livelihood sustainability in the study area is confronted with increasing pressure, and household non-farm employment has an increasing trend, while regional appropriate-scale agricultural management is maintained. The research results establish the theoretical foundation and a basic method for developing sustainable farmland use management that can meet the willingness of households and guarantee grain and ecological security.
A Cosmological Model Describing the Early Inflation, the Intermediate Decelerating Expansion, and the Late Accelerating Expansion of the Universe by a Quadratic Equation of State
Authors: Chavanis Pierre-Henri
Published: November 2015

We develop a cosmological model based on a quadratic equation of state \(p/c^2=-(\alpha+1){\rho^2}/{\rho_P}+\alpha\rho-(\alpha+1)\rho_ {\Lambda}\), where \(\rho_P\) is the Planck density and \(\rho_{\Lambda}\) the cosmological density, ``unifying'' vacuum energy and dark energy in the spirit of a generalized Chaplygin gas model. For \(\rho\rightarrow \rho_P\), it reduces to \(p=-\rho_P c^2\) leading to a phase of early accelerating expansion (early inflation) with a constant density equal to the Planck density \(\rho_P=5.16 \times 10^{99}\, {\rm g}/{\rm m}^3\) (vacuum energy). For \(\rho_{\Lambda}\ll\rho\ll \rho_P\), we recover the standard linear equation of state \(p=\alpha \rho c^2\) describing radiation (\(\alpha=1/3\)) or pressureless matter (\(\alpha=0\)) and leading to an intermediate phase of decelerating expansion. For \(\rho\rightarrow \rho_{\Lambda}\), we get \(p=-\rho_{\Lambda} c^2\) leading to a phase of late accelerating expansion (late inflation) with a constant density equal to the cosmological density \(\rho_{\Lambda}=7.02\times 10^{-24}\, {\rm g}/{\rm m}^3\) (dark energy). The pressure is successively negative (vacuum energy), positive (radiation and matter), and negative again (dark energy). We show a nice ``symmetry'' between the early universe (vacuum energy \(+\) \(\alpha\)-fluid) and the late universe (\(\alpha\)-fluid \(+\) dark energy). In our model, they are described by two polytropic equations of state with index \(n=+1\) and \(n=-1\) respectively. Furthermore, the Planck density \(\rho_P\) in the early universe plays a role similar to the cosmological density \(\rho_{\Lambda}\) in the late universe. They represent fundamental upper and lower density bounds differing by \(122\) orders of magnitude. The cosmological constant ``problem'' may be a false problem. We study the evolution of the scale factor, density, and pressure. Interestingly, our quadratic equation of state leads to a fully analytical model describing the evolution of the universe from the early inflation (Planck era) to the late accelerating expansion (de Sitter era). These two phases are bridged by a decelerating algebraic expansion (\(\alpha\)-era). Our model does not present any singularity at \(t=0\) and exists eternally in the past (although it may be incorrect to extrapolate the solution to the infinite past). On the other hand, it admits a scalar field interpretation based on an inflaton, quintessence, or tachyonic field. Our model generalizes the standard \(\Lambda\)CDM model by incorporating naturally a phase of early inflation that avoids the primordial singularity. Furthermore, it describes the early inflation, the intermediate decelerating expansion, and the late accelerating expansion of the universe simultaneously in terms of a single equation of state. We determine the corresponding scalar field potential that unifies the inflaton and quintessence potentials.
Mealworms for Food: A Water Footprint Perspective
Authors: Miglietta Pier , De Leo Federica , Ruberti Marcello , Massari Stefania
Published: November 2015

In this paper, we have explored the possibility of substituting traditional meat products with an alternative source of protein (insects) in order to reduce human pressure on water. Insects, in fact, could represent a good alternative source of quality proteins and nutrients and they are already a very popular component of the diet of one third of the world’s population in approximately 80% of countries. In the study, we have taken into account only two species of edible insects (Tenebrio molitor and Zophobas morio mealworms), because they are already commercially produced even in Western countries, and for this reason it is possible to find specific data in literature about their diets. We have used the water footprint (WF) as a reliable indicator to calculate the volume of water required for production and to compare different products. The final aim of the work is, in fact, to evaluate the WF of the production of edible insects with a focus on water consumption associated with protein content, in order to make a comparison with other animal protein sources. We have demonstrated that, from a freshwater resource perspective, it is more efficient to obtain protein through mealworms rather than other traditional farmed animals.