bluuebunny/crossref_metadata_2025 huggingface dataset:
Reception of China in the works of F. Nietzsche: the imagological aspect
Authors:   Gansu University of Political Science and Law, Pronkina O. F.
Published: July 2022

The author of the article, Olha Pronkina, studied the reception of China in the works of F. Nietzsche „The Gay Science” and „Beyond Good and Evil”. The article notes that the ethnic images of China were perceived by F. Nietzsche in a fragmentary way, since the German thinker never engaged in their fundamental study. The author of the article notes that the style of F. Nietzsche's works is characterized by aphorism. This individual author's feature makes his work unique. Olha Pronkina proves that the content of the works of F. Nietzsche testifies to the conscious desire of the German thinker to provoke the reader, to induce him to various external or internal manifestations. The works of F. Nietzsche are characterized by introspection, this determines the peculiarity of the thinker's creative method. Olha Pronkina proves that the features of the author's style indicate that the works of F. Nietzsche should be considered not only as philosophical, but also literary. The works of F. Nietzsche, in which the author refers to China, contain many errors and inaccuracies. The reception of China by F. Nietzsche is due to the fact that he perceives its culture, history and literature, on the one hand, through the prism of thinking of a European person, on the other hand, through his own criticism of the Chinese tradition. . Olha Pronkina proved that F. Nietzsche's work „The Gay Science” mentions China almost for the first time. The culture of China in this work is represented by certain stereotypes that existed at that time in the European intellectual space. In the work „Beyond Good and Evil” the German thinker mentions China several times. Olha Pronkina emphasizes that this work also represents the stereotypical reception of the ethnic image of China, which appears as a frozen culture incapable of development. In this work, F. Nietzsche creates stereotypical images of the Chinese, who are characterized by timidity, indecision, and self-abasement. Olha Pronkina proves that F. Nietzsche contrasts the ethnic images of the Chinese with the ancient Greeks, who, in his opinion, are more resolute and courageous.
Semiotics of Ukrainian and English intellectual novels in “man is a commodity” context
Authors:   Luhansk State University of Internal Affairs named after E. O. Didorenko, Khairulina N. F. , Dmytrenko V. I. ,   Kryvyi Rih State Pedagogical University
Published: July 2022

The article under consideration is devoted to the actual topic in modern society, which is investigated through the scope of Ukrainian and English intellectual novels “Misto” by V. Pidmohylnyi and “The Picture of Dorian Gray” by O. Wilde. This topic reveals the principle that life is a fair”, i. e. everything could be bought and sold, and a man is a commodity in this cruel world. The novelty of the research is that it is the first time an attempt to identify and explore the artistic-semiotic model of “life is a fair” in the works by O. Wilde and V. Pidmohylnyi in the perspective of modern comparative literature; the artistic-semiotic model of "life-fair" in a number of works of Ukrainian and English literature is systematically considered; the functioning of the model at the poetic and semiotic levels is comprehensively analyzed; the main structural elements of the literary model (constant and transient) are highlighted; a comparative-typological comparison of the creative work of writers was made, as well as the role and significance of a complex artistic-semiotic analysis of a literary work were specified. Further development of certain provisions of the research in future literary studies is likely on the basis of not only comparative but also theoretical vectors, which will be based on a more detailed study of the artistic and semiotic space of each of the studied artists. This will create an opportunity to identify complex artistic and semiotic paradigms of modeling the brightest representatives of domestic and world literature.
Genre specifics of «The Adventures of Tom Sawyer» by Mark Twain
Authors:   Poltava State Agrarian University, Liulka V. M. , Tarasova N. I. ,   Poltava V. G. Korolenko National Pedagogical University
Published: July 2022

The article illustrates that “The Adventures of Tom Sawyer” has a number of features characteristic of the novel as a kind of epic: a fairly large volume of work, the epicness of the author's story, full of dialogues and monologues. It is noticed that the plot narrative is not as detailed as in the classic samples of novels, although it has three plot lines. The work is quite simple in compositional structure, and the characters at the time of the story are almost formed. Although “The Adventures of Tom Sawyer” tells of the protagonist's private life in inseparable connection with the life of society, there is no scale to its image. “The Adventures of Tom Sawyer” highlights the features of the following genres: 1) adventure – adventure themes, the saturation of the plot with unusual events and their unexpected turn; the presence of mystery and two groups of characters – heroes and villains; 2) autobiographical – specific facts of the writer's biography, the presence of most characters real prototypes; 3) family and household – the author touches on the life and everyday life of ordinary people, relationships in the family and society, moral values and immoral acts, education and upbringing, friendship and love; 4) school story – the dynamism of the plot from the life of school children; depiction of the activities of the educational institution and participants in the educational process, children's life in extracurricular activities; 5) literary parody – similarity of the internal structure of the work with Don Quixote by Cervantes and the main characters of these works about their lives according to the laws of books, as well as parodies of adventure novels about robbers through children's play, Sunday school books through the image of “bad boy” Tom and on the relationship of adults in love because of Tom's love for Becky; 6) humorous and satirical – Mark Twain considers the realities of life exclusively through the prism of laughter, using various means of comic – from light irony to sarcasm. It is proved that “The Adventures of Tom Sawyer” is an adventure and humorous story and a work that combines features of several genres, i.e. polygenre.
Validación psicométrica de la batería UNIPSICO en valenciano/catalán: análisis de las escalas que evalúan las variables psicosociales de demanda
Authors: Llorca-Rubio José Luis , Llorca-Pellicer Marta , Gil-Monte Pedro R. , Gil-LaOrden Pedro
Published: July 2022

Objetivo: Analizar las propiedades psicométricas de las escalas de demandas de la batería UNIPSICO del contexto de trabajo en valenciano/catalán.

Método: La muestra la constituyen 2114 trabajadores de centros públicos de la Generalitat Valenciana, de la provincia de Valencia. La recogida de datos se realizó mediante las escalas de la batería UNIPSICO que evalúan factores psicosociales de demandas en el trabajo (33 ítems), que se agrupan en 6 escalas: Conflicto de rol (5 ítems), ambigüedad de rol (5 ítems), carga de trabajo (6 ítems), conflictos interpersonales (6 ítems), inequidad en los intercambios sociales (5 ítems), y conflicto trabajo-familia/familia-trabajo (6 ítems). Se realizó un análisis factorial confirmatorio (AFC) y se calcularon los valores alfa de Cronbach y omega de McDonald para las escalas.

Resultados: Todos los ítems presentaron valores estadísticos y psicométricos adecuados. El modelo de seis factores que reproduce la estructura original del cuestionario presentó un ajuste adecuado a los datos, con invarianza de sexo. El valor del alfa de Cronbach y omega de McDonald resultó aceptable para las seis escalas del instrumento.

Conclusiones: Estos resultados contribuyen a la validación psicométrica del cuestionario, permitiendo concluir que las escalas de demandas de la batería UNIPSICO, en valenciano/catalán resulta un instrumento fiable y con consistencia interna para evaluar los riesgos psicosociales en personal que trabaja en la administración.
Eficacia preventiva de los planes de seguridad y salud en el trabajo
Authors: Segarra Cañamares María
Published: July 2022

Entrevista a la Dra. María Segarra Cañamares
Thioredoxin1 Gene Modulates Bcl2/p53/NF-KB Signaling Pathways in Strawberry Extract/Paracetamol-treated Rat Model of Acute Liver Injury
Authors: Fayed Aysam , Ramadan Hala O , Hassan Soha A. , A. Hussein Mohammed , Roshdy Tamer
Published: July 2022

When used in excess, the analgesic paracetamol can cause hepatic centrilobular necrosis, which can be fatal. The goal of this study was to see if strawberry extract could protect rats' livers from paracetamol-induced hepatotoxicity. Strawberry (75 and 150 mg/kg bw) and vit C (1 g /kg bw) were given orally, daily for 15 days demonstrated a significant reduction in the effects of caused changes in plasma cholesterol, triacylglycerol, phospholipids and vit C, TBARS, GSH, TNF-α, IL-4 and NO, AST, ALT, ALP, LDH, SOD, GPx and GSH levels. Furthermore, strawberry extract significantly inhibits hepatocyte B-cell lymphoma 2 (Bcl2) but significantly induces p53, NF-KB and Trx1 gene expression compared to paracetamol- treated rats. Histological examination showed that significant normalization has been observed in strawberry extract treated rats. Conclusions Strawberry extract shows considerable hepatoprotective benefits in the case of paracetamol-induced liver damage, confirming it's essential use as a treatment for liver damage.
Effects of Amnion Lyophilization Sterile Radiation on Vascular Endothelial Growth Factor and Cluster of Differentiation 34 in Nonunion Fractures
Authors: Fauzi Ahmad , Alvarino Alvarino , Yanwirasti Yanwirasti , Sahputra Roni Eka
Published: July 2022

One of the causes of nonunion is inadequate vascularization due to severe injury mechanisms that cause defective bone healing factors. Therefore, in non-union fractures, a trigger is needed for the growth factors to work properly. This study aimed to determine the effects of ALSR on VEGF and CD-34 in non-union fractures. This study used an experimental post-test only control group design that involved white rats of the Sprague-Dawley strain. The VEGF expression was assessed by anti-VEGF staining, which was done by cutting paraffin blocks into a thickness of 5 μm, then the blocks were deparaffinized in xylol and rehydrated with alcohol. The results of the analysis are displayed with their mean ranks between control groups and treatment groups. It was found that CD-34 expression was high in the ALSR group. This shows the occurrence of angiogenesis and the regeneration in the case of non-union fractures in this study.
Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract of Elaeocarpus Tectorius (Lour.) Poir. Leaves in Streptozotocin- Nicotinamide Induced Diabetic Rats
Authors: Manoharan Keerthana , P Chitra P Chitra
Published: July 2022

The prevalence of diabetes is growing at an alarming rate on a global scale with approximately 536.6 million people having diabetes in 2021. Medicinal plants are gaining recognition in the treatment of diabetes owing to their safety, ability and low cost. Elaeocarpus tectorius (Lour.) Poir. is one of the least explored plants belonging to the genus Elaeocarpus. With this context, the current study was aimed to explore the antidiabetic and hypolipidemic effect of ethanolic extract of E. tectorius leaves in diabetes-induced rats. Phytochemical screening was performed and the oral acute toxicity of the plant extract was explored. Experimental diabetes was induced using streptozotocin and nicotinamide. The experimental animals were orally treated with ethanolic leaf extract of E. tectorius at doses 200 mg/kg b.w. and 400 mg/kg b.w. for 28 days after which body weight, fasting blood glucose levels, markers of serum lipid profile and histological variations in the pancreas were ascertained. Oral treatment of E. tectorius leaf extract daily for 28 days has significantly brought down (p<0.05) the fasting glucose levels in streptozotocin-nicotinamide induced diabetic rats and normalized the levels of serum lipid profile markers. The histological investigation revealed that the extract has caused significant restoration of pancreatic islet cells, and it was found that the dose of 400 mg/kg b.w. was more efficient and successful in treating hyperglycemia and circumventing related complications than 200 mg/kg b.w. The present study suggests that the leaf extract of E. tectorius possesses good antidiabetic and hypolipidemic activity and can be a useful and cheap alternative to treat diabetes.
Context-aware Based Personalized Recommendation on Mobile for Monitoring Excessive Sugar Consumption of Thai Adolescents
Authors: Suwan Rodjana , Temdee Punnarumol , Prasad Ramjee
Published: July 2022

Given the harmful effects of excessive sugar consumption, everyone should be aware of the amount of sugar they consume in daily life. Generally, managing nutrition and preventing negative effects from sugar intake requires a nutritional specialist or specialized knowledge, which may not always be readily accessible or understandable. Therefore, there is a need for a mobile application that can track excessive sugar consumption. This study proposes a context-aware personalized recommendation mobile application for monitoring excessive sugar consumption and providing individual recommendations (based on a predefined set of 144 rules) to Thai adolescents. The application is user friendly and can be used to provide recommendations to users for sugar consumption and proper exercise each day. Personal, health, and lifestyle data are collected and analyzed to provide individualized recommendations to each user. Experiments were conducted with 140 Thai adolescents aged 15 to 25 years old. Users’ preferences regarding degree of awareness in presentation style were also investigated. Users rated their satisfaction with the proposed mobile application as very high in terms of both function and personalization. In addition, fully automated recommendations were found to be the preferred degree of awareness among the test group.
Inverse design of hybrid metal-dielectric guided mode resonance optical filters with a deep learning neural network and Fano function matching
Authors: Shen Ruoyu , He Rong , Chen Liangyao , Guo Junpeng
Published: July 2022

In this work, we propose and implement a machine learning method of using a forward deep learning neural network and Fano function inverse matching to design and optimize hybrid metal-dielectric guided mode resonance narrow linewidth optical filters. First, a forward deep learning neural network is trained with a small design sample set generated with finite difference time domain physical simulations. The trained forward neural network is then used to generate a large sample set of three million designs. In inverse matching process, filter peak wavelength and spectral linewidth are two matching parameters first used for down selecting designs from the large sample set to a small sample set. Because of the asymmetric nature of the guided mode resonance filter spectral line-shape, Fano functions are used to match against the spectra in the small sample set to find the design with narrow filter linewidth. Optical transmission filters with linewidth between 6.8 nm and 8.7 nm are designed in visible spectrum.
Fine-mapping from summary data with the “Sum of Single Effects” model
Authors: Zou Yuxin , Carbonetto Peter , Wang Gao , Stephens Matthew
Published: July 2022

In recent work, Wang et al introduced the “Sum of Single Effects” (SuSiE) model, and showed that it provides a simple and efficient approach to fine-mapping genetic variants from individual-level data. Here we present new methods for fitting the SuSiE model to summary data, for example to single-SNP z-scores from an association study and linkage disequilibrium (LD) values estimated from a suitable reference panel. To develop these new methods, we first describe a simple, generic strategy for extending any individual-level data method to deal with summary data. The key idea is to replace the usual regression likelihood with an analogous likelihood based on summary data. We show that existing fine-mapping methods such as FINEMAP and CAVIAR also (implicitly) use this strategy, but in different ways, and so this provides a common framework for understanding different methods for fine-mapping. We investigate other common practical issues in fine-mapping with summary data, including problems caused by inconsistencies between the z-scores and LD estimates, and we develop diagnostics to identify these inconsistencies. We also present a new refinement procedure that improves model fits in some data sets, and hence improves overall reliability of the SuSiE fine-mapping results. Detailed evaluations of fine-mapping methods in a range of simulated data sets show that SuSiE applied to summary data is competitive, in both speed and accuracy, with the best available fine-mapping methods for summary data.
HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington’s disease pathogenesis
Authors: Xu Shiyu , Li Gang , Ye Xin , Chen Dongsheng , Chen Zhihua , Xu Zhen , Daniele Moretti , Tambone Sara , Ceccacci Alessandra , Tomei Licia , Ye Lili , Yu Yue , Solbach Amanda , Farmer Stephen M. , Stimming Erin Furr , McAllister George , Marchionini Deanna M. , Zhang Sheng
Published: July 2022

Perturbation of huntingtin (HTT)’s physiological function is one postulated pathogenic factor in Huntington’s disease (HD). However, little is known how HTT is regulated in vivo. In a proteomic study, we isolated a novel ~40kDa protein as a strong binding partner of Drosophila HTT and demonstrated it was the functional ortholog of HAP40, an HTT associated protein shown recently to modulate HTT’s conformation but with unclear physiological and pathologic roles. We showed that in both flies and human cells, HAP40 maintained conserved physical and functional interactions with HTT. Additionally, loss of HAP40 resulted in similar phenotypes as HTT knockout. More strikingly, HAP40 strongly affected HTT’s stability, as depletion of HAP40 significantly reduced the levels of endogenous HTT protein while HAP40 overexpression markedly extended its half-life. Conversely, in the absence of HTT, the majority of HAP40 protein were degraded, likely through the proteasome. Further, the affinity between HTT and HAP40 was not significantly affected by polyglutamine expansion in HTT, and contrary to an early report, there were no abnormal accumulations of endogenous HAP40 protein in HD cells from mouse HD models or human patients. Lastly, when tested in Drosophila models of HD, HAP40 partially modulated the neurodegeneration induced by full-length mutant HTT while showed no apparent effect on the toxicity of mutant HTT exon 1 fragment. Together, our study uncovers a conserved mechanism governing the stability and in vivo functions of HTT and demonstrates that HAP40 is a central and positive regulator of endogenous HTT. Further, our results support that mutant HTT is toxic regardless of the presence of its partner HAP40, and implicate HAP40 as a potential modulator of HD pathogenesis through its multiplex effect on HTT’s function, stability and the potency of mutant HTT’s toxicity.
Enrichment of centromeric DNA from human cells
Authors: Gamba Riccardo , Mazzucco Giulia , Wilhelm Therese , Velikovsky Leonid , Salinas-Luypaert Catalina , Chardon Florian , Picotto Julien , Bohec Mylène , Baulande Sylvain , Doksani Ylli , Fachinetti Daniele
Published: July 2022

Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-stretches of tandem repetitive arrays. Despite being quite abundant compared to other loci, centromere sequences overall still represent only 2 to 5% of the human genome, therefore studying their genetic and epigenetic features is a major challenge. Furthermore, sequencing of centromeric regions requires high coverage to fully analyze length and sequence variations, and this can be extremely costly. To bypass these issues, we have developed a technique, named CenRICH, to enrich for centromeric DNA from human cells based on selective restriction digestion and size fractionation. Combining restriction enzymes cutting at high frequency throughout the genome, except within most human centromeres, with size-selection of fragments >20 kb, resulted in over 25-fold enrichment in centromeric DNA. High-throughput sequencing revealed that up to 60% of the DNA in the enriched samples is made of centromeric repeats. We show that this method can be used in combination with long-read sequencing to investigate the DNA methylation status of certain centromeres and, with a specific enzyme combination, also of their surrounding regions (mainly HSATII). Finally, we show that CenRICH facilitates single-molecule analysis of replicating centromeric fibers by DNA combing. This approach has great potential for making sequencing of centromeric DNA more affordable and efficient and for single DNA molecule studies.
Clinical, epidemiological, and spatial features of human rabies cases in Metro Manila, the Philippines from 2006 to 2015
Authors: Guzman Ferdinand D. , Iwamoto Yuta , Saito Nobuo , Salva Eumelia P. , Dimaano Efren M. , Nishizono Akira , Suzuki Motoi , Oloko Oladeji , Ariyoshi Koya , Smith Chris , Parry Christopher M. , Solante Rontgene M.
Published: July 2022

Rabies remains a public health problem in the Philippines despite the widespread provision of rabies vaccines and rabies immunoglobulin (RIG) as post-exposure prophylaxis (PEP). Detailed descriptions of recent human rabies cases in the Philippines are scarce. This study aimed to describe the clinical, epidemiological, and spatial features of human rabies cases between January 1, 2006, and December 31, 2015. We conducted a retrospective hospital-based case record review of all patients admitted to one referral hospital in Manila who received a clinical diagnosis of rabies. During the 10-year study period there were 575 patients (average 57.5 cases per year, range 57 to 119) with a final diagnosis of rabies. Most patients were male (n = 404, 70.3%) and aged ≥ 20 years (n = 433, 75.3%). Patients mostly came from the National Capital Region (n = 160, 28.0%) and the adjacent Regions III (n = 197, 34.4%) and IV-A (n = 168, 29.4%). Case mapping and heatmaps showed that human rabies cases were continuously observed in similar areas throughout the study period. Most patients had hydrophobia (n = 444, 95.5%) and/or aerophobia (n = 432, 93.3%). The leading causative animals were dogs (n = 421, 96.3%) and cats (n = 16, 3.7%). Among 437 patients with animal exposure history, only 42 (9.6%) had been administered at least one rabies vaccine. Two patients (0.5%), young children bitten on their face, had received and a full course of rabies vaccine. Human rabies patients were continuously admitted to the hospital, with no notable decline over the study period. The geographical area in which human rabies cases commonly occurred also did not change. Few patients received PEP and there were two suspected cases of PEP failure. The retrospective design of this study was a limitation; thus, prospective studies are required.
Implementing a self-monitoring application during pregnancy and postpartum for rural and underserved women: A qualitative needs assessment study
Authors: Vernon Marlo M. , Yang Frances M.
Published: July 2022

Background

Georgia has one of the highest maternal mortality rates within the US. This study describes the qualitative needs assessment undertaken to understand the needs of rural and underserved women and their perspectives on implementing a self monitoring application during pregnancy and postpartum.

Methods

Qualitative methodology was used to conduct the needs assessment of 12 health care providers (nurses, nurse-midwives, patient care coordinators, and physicians) and 25 women from rural and underserved populations in Georgia was conducted to ascertain common themes on three topics: pregnancy care experiences, comfort with technology, and initial perspectives on the proposed VidaRPM application. Transcription, coding, and consensus were conducted using content analysis and a Cohen’s Kappa coefficient was calculated to identify level of overall agreement between raters for the representative quotes identified for each theme.

Results

The overall agreement for the representative quotes that were chosen for each theme was in strong agreement (κ = 0.832). The major provider feedback included the following regarding the VidaRPM app: inclusion of questions to monitor physical well-being, embedded valid and reliable educational resources, and multiple modalities. The overall feedback from the mothers regarding the VidaRPM application was the virtual aspect helped overcome the barriers to accessing care, comfort with both WiFi and technology, and sustainable utility.

Discussion

The needs of rural and underserved pregnant women and their providers were assessed to develop and refine the VidaRPM app. This qualitative study on the VidaRPM app is the first step towards closing the gap between providers and patients during prenatal and postpartum periods by empowering and educating women into the first-year postpartum living in rural and underserved areas.
COVID-19 risk score as a public health tool to guide targeted testing: A demonstration study in Qatar
Authors: Abu-Raddad Laith J. , Dargham Soha , Chemaitelly Hiam , Coyle Peter , Al Kanaani Zaina , Al Kuwari Einas , Butt Adeel A. , Jeremijenko Andrew , Kaleeckal Anvar Hassan , Latif Ali Nizar , Shaik Riyazuddin Mohammad , Abdul Rahim Hanan F. , Nasrallah Gheyath K. , Yassine Hadi M. , Al Kuwari Mohamed G. , Al Romaihi Hamad Eid , Al-Thani Mohamed H. , Al Khal Abdullatif , Bertollini Roberto
Published: July 2022

We developed a Coronavirus Disease 2019 (COVID-19) risk score to guide targeted RT-PCR testing in Qatar. The Qatar national COVID-19 testing database, encompassing a total of 2,688,232 RT-PCR tests conducted between February 5, 2020-January 27, 2021, was analyzed. Logistic regression analyses were implemented to derive the COVID-19 risk score, as a tool to identify those at highest risk of having the infection. Score cut-off was determined using the ROC curve based on maximum sum of sensitivity and specificity. The score’s performance diagnostics were assessed. Logistic regression analysis identified age, sex, and nationality as significant predictors of infection and were included in the risk score. The ROC curve was generated and the area under the curve was estimated at 0.63 (95% CI: 0.63–0.63). The score had a sensitivity of 59.4% (95% CI: 59.1%-59.7%), specificity of 61.1% (95% CI: 61.1%-61.2%), a positive predictive value of 10.9% (95% CI: 10.8%-10.9%), and a negative predictive value of 94.9% (94.9%-95.0%). The concept and utility of a COVID-19 risk score were demonstrated in Qatar. Such a public health tool can have considerable utility in optimizing testing and suppressing infection transmission, while maximizing efficiency and use of available resources.
The impact of cognitive impairment of individuals with Parkinson’s disease on their caregivers’ mental health: A systematic review protocol
Authors: Golińska Paulina Beata , Bieleninik Łucja , Harciarek Michał , Bidzan Mariola
Published: July 2022

Introduction

Parkinson’s disease is a motor disease, the second most common neurodegenerative disorder with cardinal symptoms including bradykinesia, rigidity, and rest tremor accompanied by cognitive difficulties. The caregivers play a crucial role for individuals with Parkinson’s disease; however, many of them may suffer from high caregiver burden and mental health deterioration. This protocol of a systematic review presents a methodology of the review about the impact of cognitive impairment of individuals with Parkinson’s disease on their caregivers’ mental health.

Material and methods

Research will be identified by combining electronic databases searching and hand searching. The following databases will be included: Medline, PsycInfo, Web of Sciences, Cochrane, CINAHL, Embase and Scopus. The inclusion and exclusion criteria followed to PECOS model. The population of informal caregivers is defined as family members providing care on a patient with Parkinson’s disease. Exposure is linked with the evaluation of a cognitive functioning and outcome is defined as mental health among caregivers of individuals with Parkinson’s disease. We will include two types of studies: observational and intervention. Both, screening and eligibility will be done by two independent reviewers. Study quality will be assessed by two authors independently. Data will be extracted by two reviewers independently and will follow a pre-pilot extraction form. Any discrepancies will be resolved by discussion or/and consultation with another reviewer. The synthesis without meta-analysis (SWiM) guidelines will be used to report on included studies data. The metanalysis with usage the statistical software R version 4.1.2 (2021-11-01) “Bird Hippie” and R metaphor package 3.0–2 of will be conducted if possible.

Discussion

The goal of this systematic review is to present the association between caregivers’ mental health problems and their proteges’ cognitive impairment. It will enable to identify the gaps in literature and its methodology giving the suggestions for further research.

Protocol registration

Protocol registration number in PROSPERO: CRD42022296670
Having siblings promotes a more healthy weight status—Whereas only children are at greater risk for higher BMI in later childhood
Authors: Bohn Claudia , Vogel Mandy , Poulain Tanja , Hiemisch Andreas , Kiess Wieland , Körner Antje
Published: July 2022

Background

Birth order and having at least one sibling are known to be associated with an increased risk for development of overweight. However, there are no studies assessing pre- and postnatal factors for developing overweight within families. Therefore, the present study aimed to analyse the association of the mother’s weight gain during pregnancy, prepregnancy BMI, mother’s age at birth, breastfeeding, age gap between siblings, and physical activity together with sibling-related characteristics on the development of overweight in children and adolescents.

Methods

Data were obtained from the longitudinal LIFE Child cohort. The study sample included n = 1932 children, stratified into first-born (n = 578), second-born (n = 608), third-or-later-born single-born siblings (n = 162), only children (n = 526), and twin children (n = 58). Children with chronic or syndromic diseases, born prematurely or from mothers with gestational diabetes were excluded. Data were adjusted for multiple children per family using mixed models. Pregnancy weight gain, prepregnancy BMI and mother’s age were considered prenatal co-variates. Postnatal factors included the duration of breastfeeding and the children’s physical activity level.

Results

Particularly until the onset of puberty, the BMI-SDS differed between single-born siblings, only children and twins, and increased with birth order. Compared to children with siblings, only children exhibited a strong increase in BMI-SDS starting at age nine. A higher age gap between siblings was associated with a higher BMI-SDS in second- and third-or-later-born children. Single-born siblings had the highest rate and duration of breastfeeding. Physical activity was highest in twins and third-or-later-born children and lowest in only children. In a multivariate model, being an only child showed a highly significant association with BMI-SDS.

Conclusion

The present study demonstrated that siblings had a lower BMI-SDS than only children did. For single-born siblings, the association between birth order and increased BMI-SDS seemed to persist only up to 11 years of age.
Verbs of cutting in the middle construction: Examining the compositional cospecification of patientive vs. Agent-instrument middles
Authors: Palma Gutiérrez Macarena
Published: July 2022

The purpose of this paper is to examine both prototypical Ergative-like middles (e.g. The cake cuts well) and their metonymically-motivated extensions, called Agent-Instrument middles (e.g. The saw cuts like a dream). The former incorporate as subjects patientive entities and the latter instruments. Both structures allow the incorporation of verbs of cutting, but they represent divergent portions of the action chain, and thus, they differ in the nature of their subject entities and their processes of compositional cospecification in terms of qualia structure. On the whole, on the basis of the prototype effects of the middle construction analysed here, they should be considered proper middles. This paper is based on a corpus study of contextualised examples (1700+) to examine their collostructional schema in the English middle construction (cf. Stefanowitsch and Gries 2003). Particularly, we explore the Verb + Adverb collocation found in middles by focusing on 29 predicates belonging to Levin’s (1993: 156) class of verbs of cutting, in combination with facility-/quality-oriented adjuncts (cf. Davidse and Heyvaert, 2007). Following a cognitive perspective, this paper examines the semantic roles of the subject referents analysed (patients and instruments), as well as their distinct processes of compositional cospecification as factors that contribute to the prototype effects of the middle construction. On the basis of corpus data, despite the syntactic, semantic, and pragmatic common schemas found in prototypical Ergative-like middles and Agent-Instrument middles, the prototype effects of the middle construction highlight the divergent processes of compositional cospecification that these two types of middles follow. More specifically, a shift of semantic weight from a telic to a constitutive value occurs in Agent-Instrument middles, while there is lack of such a semantic shift in terms of qualia structure in prototypical Ergative-like middles with patientive subjects. Thus the middle construction cannot be considered as a discrete category of its own, but rather a prototype category (cf. Taylor, 1995; Hundt, 2007) that permits the accommodation of central and peripheral members. Consequently, in addition to the traditionally accepted structures in which the subject referent is a patientive entity, other less archetypal nominals can occur as middle subjects, particularly, instruments whose action affects implied and patientive entities.
Integrability, rational solitons and symmetries for nonlinear systems in Biology and Materials Physics
Authors: Albares Vicente Paz
Published: July 2022

Los sistemas no lineales constituyen un tema de investigación de creciente interés en las últimas décadas dada su versatilidad en la descripción de fenómenos físicos en diversos campos de estudio. Generalmente, dichos fenómenos vienen modelizados por ecuaciones diferenciales no lineales, cuya estructura matemática ha demostrado ser sumamente rica, aunque de gran complejidad respecto a su análisis. Dentro del conjunto de los sistemas no lineales, cabe destacar un reducido grupo, pero a la vez selecto, que se distingue por las propiedades extraordinarias que presenta: los denominados sistemas integrables. La presente tesis doctoral se centra en el estudio de algunas de las propiedades más relevantes observadas para los sistemas integrables. En esta tesis se pretende proporcionar un marco teórico unificado que permita abordar ecuaciones diferenciales no lineales que potencialmente puedan ser consideradas como integrables. En particular, el análisis de integralidad de dichas ecuaciones se realiza a través de técnicas basadas en la Propiedad de Painlevé, en combinación con la subsiguiente búsqueda de los problemas espectrales asociados y la identificación de soluciones analíticas de naturaleza solitónica. El método de la variedad singular junto con las transformaciones de auto-Bäcklund y de Darboux jugarán un papel fundamental en este estudio. Además, también se lleva a cabo un análisis complementario basado en las simetrías de Lie y reducciones de similaridad, que nos permitirán estudiar desde esta nueva perspectiva los problemas espectrales asociados. Partiendo de la archiconocida ecuación de Schrödinger no lineal, se han investigado diferentes generalizaciones integrables con numerosas aplicaciones en diversos campos científicos, como la Física Matemática, Física de Materiales o Biología.
Early Modern Lutheran Theologians and the Redeemable Census
Authors: Astorri Paolo
Published: July 2022

In sixteenth-century Germany, a particular financial operation called widerkaufflicher Zins or five percent contract sparked massive legal and theological controversies. This contract produced effects like a loan and therefore countered the interest-taking prohibition. Martin Luther (1483-1546), Philipp Melanchthon (1497-1560), Johannes Brenz (1499-1570), Johannes Aepinus (1499-1553), Urbanus Rhegius (1489-1541), Martin Chemnitz (1522-1586), Aegidius Hunnius (1550-1603), and Johann Gerhard (1582-1637) addressed this issue. They ended up reformulating the prohibition on interest and mapping out a set of rules for the right use of this contract. This article will survey their opinions paying attention to the points where their teachings resembled the Catholics or where they took a different path.
'CHOKUBAISHO' AS A WAKAYAMA FRUIT FARMER DIRECT SALES SYSTEM IN JAPANESE AGRI-FOOD NETWORK GOVERNANCE
Authors: Hati Dwi Sumara , Iskandar Kurniawaty , Mizuno Kosuke
Published: July 2022

The global food system always faces threats and challenges. However, on the other hand, it is an opportunity for the Japanese civil society social movement to play an active role in building a just and sustainable food system. Chisan Chishou movement (local product, local consumption campaign) provides excellent opportunities for farmers in Prefecture Wakayama Japan to target local potential, with transparent price and added value through the Sanchoku （産直）or direct sales system. The Japanese food distribution chain is systemically coordinated below shade Kyoudou kumiai (協同組合) or JA (Japan Agricultural Cooperative), as a prominent entity in Japanese agri-food network governance. Qualitative method selected in explaining paradigm social capital and network in its role to achieve prosperity and regional economic development, by considering indicator non-physical such as the value of 'trust' and reciprocity in 'network' as the essential attributes of the social capital. The study case of farmer as a member of Japan Agricultural Cooperative (JA) Wakayama Prefecture describes how the Chokubaishou system is a strategy for the farmer to resolve problem profitability on the Chokubaishou JA system with the character of quality products at low prices. The non-binding JA membership system is a benefit for farmers in obtaining agricultural facilities and securing sales channels with a more stable market and low risk of operating costs. The mutual dependence on relational cooperation and 'trust' on this agri-food network mechanism has become a 'safety guard' for farmers, and JA perpetuates the sales business that profitable and sustainable.Keywords; Social Capital; Direct Sales System, Chokubaishou; Agri-Food Network
Innen vor Außen? Eine Schätzung der Innenentwicklung in nordrhein-westfälischen Gemeinden, 1979 bis 2011
Authors: Eichhorn Sebastian , Siedentop Stefan
Published: July 2022

Strengthening inner urban development is a guiding principle of Germany’s sustainability policy and the key to achieving the 30-hectare target. To date, however, it is hardly possible to determine retrospectively the share of building construction activity realized as inner and outer urban development. On the one hand, there is the genuine fuzziness of the inner urban area (Innenbereich) as a spatial construct, and on the other hand, there is the lack of available small-scale data on building construction activity. Against this background, this paper presents for the first time a methodological approach to determine and evaluate the relevance of inner urban development for large areas and over longer periods of time for Germany. The method is applied for the federal state of North Rhine-Westphalia and the housing construction activity from 1979 to 2011. The result shows a positive trend, indicating that cities and municipalities have succeeded in realizing more housing as inner urban development over time. At the same time, significant differences between urban and rural areas are apparent. A central conclusion is therefore to support smaller municipalities in their efforts for more inner urban development.
Failure Modes and Effect Analysis of Gear Pair
Authors: Jangra Dharmender
Published: July 2022

In the present study, the failure mode and effect analysis (FMEA) process has been used to determine the probable failure mechanisms of gear pairs and their implications on the performance, availability, and cost. The risk priority number (RPN) is calculated to rank the failure modes and identify high-risk failures. The methods are proposed to minimize high-risk failure modes.
Condition Monitoring as Tool of Engineering Management
Authors: Jangra Dharmender
Published: July 2022

With the increasing demand for the machinery's availability, it becomes critical to have a periodic check on the health status of the machinery. The process of periodic check consists of collection, processing and decision making. Condition monitoring is the process of periodic checks of the health of machine elements. The condition monitoring consists of two main components: diagnosis and prognosis. In the present work, the discussion on condition monitoring as a tool of engineering management was carried out
SÜRDÜRÜLEBİLİR KALKINMA FİNANSMANI ARAÇLARINDAN YEŞİL TAHVİL VE YEŞİL SUKUK ÜZERİNE BİR DEĞERLENDİRME
Authors: YAZICIOĞLU İ. Ebru , BAŞTAN TÖKE Leyla
Published: July 2022

Sürdürülebilir kalkınma anlayışı içinde artan küresel farkındalık ile çevreyi tahribata uğratmayan yaklaşımlara verilen önem artmıştır. Kalkınma sürecinde çevresel, sosyal ve ekonomik ilerlemeler birbiriyle bağlantılı hale gelmiştir. Bu süreçte yeşil ve yenilikçi finansman araçlarına yönelim artmıştır. Çevreyi korurken ekonomik kalkınmanın sağlanması bakış açısına dayanan yeşil tahvil (green bond), 2007 yılında dünya piyasalarında gündeme gelmiş ve Türkiye’de de 2016 yılından itibaren işlem görmeye başlamıştır. Yeşil tahvil, Dünya’da iklim değişikliği projelerine, yenilenebilir enerji kaynaklarının sağlanmasına ve kaynak verimliliği yatırımlarına fon sağlamada kullanılmaktadır. Yeşil tahvil ihracıyla elde edilen fonların yenilenebilir enerjiye destek vermesi amaçlanmaktadır. Genel tahvil özelliklerini taşıyan yeşil tahviller faiz içermesi sebebiyle İslami finansal araç olarak kullanılamamaktadır. Bu sebeple yeşil tahvillere alternatif olarak yeşil sukuk (green sukuk) geliştirilmiştir. Yeşil sukuk, sürdürülebilir kalkınma bakımından İslami finans piyasasına yeni bir bakış açısı getirmektedir. Bu çalışmada; öncelikli olarak sürdürülebilir kalkınmadan bahsedilmiştir. Ardından, yeşil tahvillerin özellikleri ve kullanım alanları üzerinde durularak yeşil sukuk fonlarının günümüzdeki kullanımı ve amaçları irdelenmiştir. Son olarak her iki finansal enstrümanın değerlendirmesinin yapıldığı bu çalışmada yeşil finansman araçlarının ağırlıklı olarak yenilenebilir enerji alanında kullanıldığı görülmüştür. Yeşil tahvil kullanımında sürekli bir artış olmasına karşılık faizli bir enstrüman olması sebebiyle İslami hassasiyete sahip olan yatırımcıların dikkatini yeşil sukuka yönlendirdiği sonucuna ulaşılmıştır. İçinde bulunduğumuz dönemde toplumun her tabakasında çevre hassasiyetinin artması avantajı içinde konvansiyonel finans için yeşil tahvil; hem konvansiyonel hem de İslami finans için yeşil sukukun yeşil büyümeye katkı sağlayacağı sonucuna ulaşılmıştır.
A balanced tri-band BPF with high selectivity based on ASSLR
Authors: Chen Lei , Wang Min , Zhang Tian Tian , Peng Jia Yi , Wei Feng
Published: July 2022

In this paper, a balanced second-order tri-band bandpass filter (BPF) with high selectivity is proposed. Three differential-mode (DM) passbands are formed by applying one pair of asymmetric short stub-loaded resonators (ASSLRs) and uniform impedance resonators (UIRs) into the design. Meanwhile, the frequencies and bandwidths of the DM passbands can be quasi-independently controlled by the lengths of resonators and the gaps between them. In addition, broadband common-mode (CM) suppression is achieved intrinsically without affecting the DM parts based on the U-type balanced stepped-impedance microstrip-slotline transition (BSIMST) structures, thereby simplifying the design procedure significantly. In order to validate the practicability, a balanced tri-band BPF operating at 1.8, 3.5 and 4.45 GHz is fabricated and designed. A good agreement between the simulated and measured results is observed.
Factors determining the flow erosion/part deformation of film insert molded thermoplastic products
Authors: Lee Demei , Lin Yu-Kai , Hsu Siang-Chen , Tang Ya-Ling , Liu Shih-Jung
Published: July 2022

Flow erosion and part deformation are unsolved molding problems that restrict the overall success of film insert molding. This work investigated, both experimentally and numerically, the factors that affect flow erosion and part deformation in film inset molded products. Three plate-with-thickness-variation geometries, namely flat, thin-to-thick, and thick-to thin, were molded for the products. Polystyrene films and polyethylene terephthalate (PET) resins were employed in the experiments. It was found that the thin-to-thick specimens exhibited the most severe flow erosion. Increasing the injection pressure or melt temperature worsened flow erosion. Meanwhile, for the processing parameters adopted in the experiments, part deformation generally increased with melt temperature and hold time, while it decreased with injection pressure and hold pressure. Additionally, a numerical software (Moldex® 3-D) was employed to simulate the temperature and shear stress distributions in molded products. The calculated results suggested that part deformation in insert molded products results mainly from the non-uniform temperature profile during the cooling stage, owing to the product configuration and the insert film, while flow erosion is induced by the high shear stress of the polymer melt in the filling stage.
Effect of lyocell fiber cross-sectional shape on structure and properties of lyocell/PLA composites
Authors: Shen Yang , Yang Gesheng , Edgar Kevin J. , Zhang Huihui , Shao Huili
Published: July 2022

Three kinds of lyocell fibers with different cross-sectional profiles including circular, Y-shape, and H-shape (abbreviated as O-, Y-, and H-lyocell) and similar mechanical properties were used to reinforce polylactic acid (PLA) by melt compounding and injection molding. The influence of lyocell cross-section shape on the interfacial shearing force, interface morphology, and mechanical properties of lyocell/PLA composites was investigated. Single fiber pull-out tests showed that the interfacial shearing force between lyocell fibers and PLA matrix was in the order of H-lyocell > Y-lyocell > O-lyocell, which was correlated with the fiber non-roundness factor. The higher the non-roundness factor of lyocell fibers, the better were the mechanical properties of lyocell/PLA composites. The tensile strength, impact strength, and initial dynamic storage modulus of different lyocell/PLA composites were in the order of H-lyocell/PLA > Y-lyocell/PLA > O-lyocell/PLA, which was attributed to higher interfacial contact area and stronger interfacial adhesion of profiled lyocell/PLA composites. Therefore, profiled lyocell fibers may be more promising for use in bio-composite reinforcement than conventional circular lyocell fibers.