bluuebunny/crossref_metadata_2025 huggingface dataset:
An Integrated Approach to the Logistics of Supply, Production and Distribution Based on the Formalization of Logistic Business Processes
Authors:   National Aviation University, Ivanenko Larysa M. , Smerichevska Svitlana V. ,   National Aviation University, Ivanenko Vladyslav I. ,   Kyiv National University of Technologies and Design
Published: June 2024

The article considers the problem of integration of logistic business processes of supply of resources (logistics), production and distribution at an industrial enterprise. The aim of the article is to develop an integrated system of logistic management of a production enterprise on the basis of a study of the mechanism for managing the material flow. As a result of the study, the principles of building a logistic system for integrated management of purchasing, production and distribution logistics of enterprise have been formulated and an integrated management scheme has been elaborated, in which complexes of tasks at certain levels of management have been allocated. At the upper level of management is the distribution of the quarterly production program by months, taking into account production capacities based on the principle of specialization of production in time. At the middle level of management – drawing up interrelated plans and schedules of logistics, manufacture and shipment of finished products. At the lower level of management – the compilation of shift-daily tasks on the basis of operational planning of the work of workshops, sites and individual workplaces. When drawing up interrelated calendar plans-schedules for the release and shipment of products, decisions are made that simultaneously meet the requirements of production and the conditions for the sale of products. These decisions are the basis ones for further specification of them by production units of the enterprise. The proposed scheme provides for communication along a closed loop of the logistic system of integrated management: planning, accounting, control, regulation. To solve problems at all levels of enterprise management, it is advisable to use modern software systems, such as SAP ERP, Oracle Supply Chain Management, Microsoft Dynamics 365 Supply Chain Management, Infor SCM, Plex Manufacturing Cloud.
The National Strategy of Development Economy: The Basic Prerequisites for Formation and Implementation
Authors:   International University of Finance, Kolishenko Ruslan O.
Published: June 2024

The aim of the article is to determine the conceptual foundations for the formation of a strategy for building the economic development. The article states that building a development economy requires the formation and implementation of an appropriate national strategy, which determines the priority areas of scaling up production and economic activity and ensures the implementation of mechanisms and tools for achieving strategic goals in the context of the formation of processes of expanded reproduction. Having analyzed the research of scholars in the field of strategizing, the characteristics that should be inherent in modern development strategies are outlined. It is noted that the substantiation of the conceptual foundations of the formation and implementation of the national strategy for building a development economy should provide for the definition of the characteristic features of economies of this type. It is substantiated that building a development economy is impossible without the presence of a stable banking and financial sector in the country, because in the context of global shocks, growing challenges and threats, its impeccable functioning should be ensured. It is determined that ensuring the efficiency of the implementation of the national strategy for building a development economy involves a focus on the basic conceptual principles, which include: an adequate institutional environment, protection of investor rights and fair justice, and the fight against corruption. Security-oriented principles, in turn, should ensure the national security of the State, the development of the military-industrial complex, countering occurrences of both armed and hybrid aggression, while the sectoral principles include a rational sectoral structure of the economy, balanced use of natural resources, and strengthening the competitive advantages of the national economy. The integration-structured principles are aimed at the European integration vector of development, an horizontal-vertical cooperation, and the harmonization of national business standards with international norms. It is defined that the totality of conceptual foundations outlined in the article for the formation and implementation of the national strategy for building a development economy should ensure the achievement of a synergistic effect, which consists in creating a balanced structure of the target strategy and guaranteeing its comprehensive nature.
Adaptation as a Component of the Staff Onboarding Process
Authors:   Chernivtsi Institute of Trade and Economics of State University of Trade and Economics, Peniuk Valeriia O.
Published: June 2024

The purpose of the article is to define the differences between the concepts of «onboarding» and «adaptation», the tasks and methods of onboarding, as well as to define the concept of onboarding as a process that ensures the effective adaptation of new employees. Nowadays, modern business is impossible without human resources. The labor market, acquaintances, interviews – all this facilitates the rapid search for new employees who can take a certain place in the organization. But can a new employee quickly adapt to a new environment and start performing tasks without financial losses for the organization during the adaptation period of the employee himself/herself? Experience shows that some employees who are on probation or have just started working cannot agree to the conditions and resign only because of difficulties in the process of adapting to the new environment. That is why both small organizations and large companies should pay attention to the importance and role of onboarding in retaining new employees for a long period of time. Some HR specialists and part of the scientific community equate onboarding with adaptation. We have identified the differences between these concepts, because, in our opinion, adaptation is a component of the staff onboarding process. The processes associated with onboarding are preboarding, offboarding, and crossboarding. The period when after the final interview and before the «newcomer» begins to perform functional duties is called preboarding. If the onboarding process still fails at the enterprise, the HR team prepares for the offboarding (dismissal) process. And if new opportunities open up for the «newcomer», then the process of crossboarding is irreversible, which ensures the successful adaptation of the employee in a new position, but within the same enterprise. Well-defined tasks and methods for implementing onboarding make it possible to reduce staff turnover among «newcomers» to enterprises. And its essence substantiates the expediency and effectiveness of onboarding in the process of personnel management in general.
Components of the Mechanism for Recovering the Socioeconomic Development of the Regions of Ukraine in the Post-War Period
Authors:   Research Centre for Industrial Problems of Development of NAS of Ukraine, Semyhulina Iryna B. , Yaroshenko Ihor V. ,   Research Centre for Industrial Problems of Development of NAS of Ukraine
Published: June 2024

The continuation of the war and the resulting significant losses in the functional capacity of the country’s territories, its human, economic, infrastructural, environmental, and other potentials have long-term negative consequences and limitations on the future development of both individual regions and the country as a whole. The objective reality of the existing problems requires the development and implementation of certain measures in order to minimize the negative consequences of these challenges on the existence and development of any territories in Ukraine. Of relevance are the development of the security space and infrastructure for the functioning of the country and its regions; the need for planning the development and recovery of the affected areas; creating conditions for the return of Ukrainian refugees and internally displaced persons; formation of safe living conditions; full access to all public services; restoration of functioning and competitiveness of local, regional and national economies, etc. In the face of the challenges caused by the war, these issues have become more specific, aimed at finding ways to rebuild the affected territories of the country, in particular in the post-war period. Analysis and generalization of approaches to the introduction of the components of the recovery mechanism into regional development, determination of its functional orientedness and principles of organization allow us to propose components of the mechanism for recovering the socioeconomic development of the regions of Ukraine in the post-war period, taking into account the security capabilities of both the State and the region. The peculiarity of the study is the formation of components of the mechanism for recovering the socioeconomic development of the regions of Ukraine in the post-war period on the basis of allocation of two kinds of groups: the main groups that correspond to the problem situations of the region and determine the directions of recovery; the auxiliary, or supportive groups, which help in the implementation of the main ones, thereby increasing the impact on solving problem situations. This allows, on the one hand, to generalize the structural elements of the mechanism, and on the other hand, to specify their use depending on functional feasibility. The stage-by-stage distribution of the components of the mechanism for recovering the socioeconomic development of the regions of Ukraine in the post-war period allows them to be grouped taking into account functional capabilities, which makes the mechanism more effective and purposeful in the process of practical implementation.
Methodological approaches to enterprise security management: traditional and transformed to the conditions of functioning
Authors: Kapeliushna T , Lehominova S , Goloborodko A , Lysetskyi Yu , Nosova T
Published: June 2024

Purpose. To analyse the methodological approaches to enterprise security management with the allocation of traditional ones and those transformed to modern uncertain conditions of functioning. Methodology. The methodological basis of the study was the scientific works by domestic and foreign scholars to identify the main theoretical provisions on approaches to security management, which were further analysed for their essence and feasibility of use in specific conditions of enterprise functioning. By combining the methods of analysis, synthesis, morphological analysis, and generalisations, the authors have managed to identify traditional approaches to enterprise management and those transformed to modern conditions which are inter-integrated and complementary. Findings. A map of the integration of traditional methodological approaches of enterprise security management and those transformed to modern conditions was formed and proposed, which can be used by enterprises to find effective approaches to security management depending on the object to which the management vector is immediately directed. Originality. The authors analyse a number of approaches to enterprise security management, starting with traditional approaches and moving towards their change depending on the conditions and environment of enterprise functioning. The authors trace the layering of several approaches on the traditional ones simultaneously, which is explained by the complication of the conditions of functioning of enterprises. The importance of finding approaches to management depending on the conditions of functioning of the enterprise and the security object to which security management is focused is emphasised. Practical value. The analysis and the results obtained are of practical value in terms of the feasibility of application at enterprises regardless of their industry, in addition to the effectiveness of the proposed map of approaches, which is variably integrated, taking into account the conditions and the object of management. This will allow one to broadly cover security issues and methodically solve them using a specifically selected approach.
الخطاب الديماغوجي للشخصيات السياسية العراقية في قنوات الفضائية
Authors: كريم مريم محسن , مصطاف عادل عبدالرزاق
Published: June 2024

يتناول البحث الخطابات الديماغوجية للشخصيات السياسية العراقية المشاركة في برنامج "الحق يقال" وبرنامج "من الأخير"، وتحليلها على وفق إحدى أدوات تحليل الخطاب وهي أداة تحليل الاطروحات، وتحليل السياق، ويعدّ هذا البحث من البحوث الوصفية، اعتمدت فيه الباحثة على المنهج المسحي في إجراء الدراسة، والتحليل الكميّ والكيفيّ في تحليل الخطاب، وقد صممت الباحثة استمارة تحليل الخطاب وفقًا لذلك؛ للحصول على النتائج التي من أبرزها: ظهور فئة الاطروحات السياسية كفئة رئيسة اعتمدت في الخطاب، وتصدرت فئة أزمة تشكيل الحكومة الفئات الفرعية؛ وذلك لأن الفترة الزمنية التي خضعت للتحليل كانت أبرز أزمة سياسية فيها أزمة تشكيل الحكومة وما ظهر في تحليل السياق أيضاً.
EMPOWERING ADOLESCENTS: THE CRUCIAL ROLE OF SCHOOL GUIDANCE AND COUNSELLING SERVICES IN ADDRESSING EDUCATIONAL CHALLENGES IN SRI LANKA
Authors: JAYASEKARA THANUJA HARSHANIE
Published: July 2024

School Guidance and Counselling services are universally implemented to facilitate students in realizing their full potential and shaping their future lives (Smith, 2020)1. While these services play a crucial role in meeting the diverse needs of students in Sri Lanka, research indicates operational challenges (Buddhiprabha, 2016)2. This article presents findings from a survey study conducted to explore how school guidance and counselling units in Sri Lanka can contribute to resolving educational problems faced by adolescents. The main research study employed a mixed-methods design, incorporating 275 students, 24 class teachers, 5 principals and 5 counselling teachers in the Walasmulla Educational zone in Sri Lanka. The data collection involved the use of questionnaires and interviews. Quantitative analysis was conducted using percentages and charts, while qualitative analysis relied on summaries descriptive essays and structured compositions. Results highlights prevalent educational problems among adolescents, predominantly cognitive issues. Challenges related to studying, exams, the learning process, and external factors were also identified. Despite efforts by school guidance and counselling units to address these challenges, they have not been entirely successful. Notably, students who received direct counselling support reported significant assistance in overcoming their educational hurdles. This underscores the importance of formalized support structures within school guidance and counselling units in providing practical solutions to adolescents' educational challenges, ultimately better preparing them for the future.
Interruptions Employed by the Participants of Ellen DeGeneres Show
Authors: Fatonah Astri Amaliah , Sofyan Dedi , Zahrida Zahrida
Published: June 2024

This research aimed to find out the dominant types of interruptions employed by participants and to find out the purposes of interruptions done by the participants of Ellen DeGeneres show. This research employed quantitative descriptive research. The subjects of this research were two of the most viewed videos uploaded from October-November 2020. The interruption employed by the participants and the purposes of interruptions done by the participants were classified using an instrument datasheet following Murata’s theory. The first results of this research show that interruptions types done by the participants of the Ellen DeGeneres show namely cooperative and intrusive, and the dominant types employed in the Ellen DeGeneres show was a cooperative interruption. The second result finding showed all that the purposes of interruptions done by the participants of the Ellen DeGeneres show namely agreement, assistance, clarification, disagreement, floor-taking, and tangentialization.
MODEL PERLINDUNGAN DARING: IMPLEMENTASI MODEL BARU DALAM MENGHADAPI TANTANGAN CYBERBULLYING DI KOTA MAGELANG
Authors: Mulyani Sri , Rihardi Satrio Ageng , Pembayun Jaduk Gilang
Published: July 2024

Abstract: This research aims to analyze and evaluate a new online protection model in response to the increasing challenges of cyberbullying in Magelang City. With a focus on the case study of the Regional Child Protection Commission (KPAD) of Magelang City, this research provides an in-depth insight into the dynamics of child protection in the digital era. Qualitative methodology and R&D methods were used to test the new cyberbullying prevention and handling model of KPAD Kota Magelang. Data were analyzed using descriptive qualitative methods and NVivo 12 Plus software. The results of the research analysis show that the proposed online protection model can overcome the limitations and challenges identified from previous research. It is expected that this research will not only develop an innovative and effective online protection model to protect children from the negative impact of information technology but will also contribute significantly to the development of understanding and implementation of child protection in facing the challenges of cyberbullying at the local, regional, and national levels.

Abstrak: Penelitian ini bertujuan untuk menganalisis dan mengevaluasi model perlindungan daring baru sebagai respons terhadap meningkatnya tantangan cyberbullying di Kota Magelang. Dengan fokus pada studi kasus Komisi Perlindungan Anak Daerah (KPAD) Kota Magelang, penelitian ini memberikan wawasan mendalam tentang dinamika perlindungan anak di era digital. Metodologi kualitatif dan metode R&D digunakan untuk menguji model pencegahan dan penanganan cyberbullying yang baru dari KPAD Kota Magelang. Data dianalisis dengan menggunakan metode deskriptif kualitatif dan software NVivo 12 Plus. Hasil analisis penelitian menunjukkan bahwa model perlindungan daring yang diusulkan dapat mengatasi keterbatasan dan tantangan yang teridentifikasi dari penelitian sebelumnya. Diharapkan bahwa penelitian ini tidak hanya akan menyusun model perlindungan daring yang inovatif dan efektif untuk melindungi anak-anak dari dampak negatif teknologi informasi, tetapi juga akan memberikan kontribusi signifikan terhadap perkembangan pemahaman dan implementasi perlindungan anak dalam menghadapi tantangan cyberbullying di tingkat lokal, regional, dan nasional.
The Relevance of English Teaching Materials for Primary Schools with Religious Moderation Values: A Review
Authors: Ghufron M. Ali , Rohman Taufiqur , Aditia M. Rifki
Published: June 2024

This research aimed to evaluate the relevance of the English teaching materials in the textbook “My Next Words (For Elementary School 5)” concerning the values of religious moderation as adopted in primary schools. The textbook has received endorsement from the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia, highlighting the importance of evaluating its alignment with the government's religious moderation standards. The research methodology employed content analysis of the textbook to identify content related to religious moderation values. Surveys and interviews with elementary school teachers using this textbook provided insights into its utilization and its reflection of religious moderation values in teaching practices. The results indicated that the textbook primarily focuses on language skills, with limited integration of religious moderation values. It lacks sensitive language usage and activities promoting interfaith understanding. However, it does feature diverse character names associated with specific religious groups and incorporates some aspects of cultural diversity. Educators expressed the importance of integrating religious moderation values into English language teaching materials, but they found the current materials lacking in this regard. In conclusion, the textbook “My Next Words: For Elementary School” for Grade V requires improvements to better integrate religious moderation values. These enhancements will contribute to a more inclusive and relevant English language learning experience for elementary school students, fostering tolerance and interfaith harmony.
Students’ Reading Comprehension of English Textual Literacy Among Zillenial Generation
Authors: Rahmawati Yeni , Khatimah Khusnul , Rachman Dzul , Sunarti Sunarti
Published: June 2024

According to the Indonesian new curriculum which is generally called Kurikulum Merdeka reading comprehension of text becomes a fundamental skill of learning outcomes.  However, a long time before the new curriculum was released reading skills, especially in learning a foreign language particularly English have always been the main thing. Starting from this condition, this study aimed to describe the students’ reading comprehension of English textual literacy among the Zillenial generation. Another goal, of this study, was to identify the students’ reasons related to their reading in textual comprehension. This study applied mixed methods both quantitative and qualitative. The design used descriptive statistics and interviews. the instrument used was a test and a list of interviews. the population in this study was 99 students of Public Vocational Schools in Samarinda whereby, overall, this population also became the sample.  The result was the students in the fair category. The majority of students got a score around 70 which was included as a fair category. This is in line with the school policy of considering minimum passing grades in English subjects. From qualitative data, it was found that the students were helped by the test which was considered as lower-order thinking (LOT). The test was in multiple choice and the topic was familiar. Surprisingly, based on the findings, this Zillenial generation has low literacy as they acknowledged that they don’t have any specific time for doing English literacy except only the teacher’s command. If the topic of the text is considered difficult usually, they will use translator apps to comprehend the text easily.
Acanthaceae Juss. no município de Vitória da Conquista, Bahia, Brasil
Authors: Soares Gabriel Chaves , Caires Claudenir Simões
Published: July 2024

Acanthaceae está entre as 12 famílias de angiospermas mais diversas, representada por 190 gêneros e estimadas 4.900 espécies, com distribuição pantropical. O respectivo trabalho realizou um levantamento florístico das Acanthaceae no município de Vitória da Conquista, Bahia, região de tensão ecológica entre Caatinga e Mata Atlântica. Foram realizadas 28 expedições durante o período de dezembro/2021 a outubro/2023, abrangendo todo o município, além de duas coletas extras em abril/2024. Essas coletas foram quinzenais (fora da época de floração) e semanais (época de floração), e totalizaram 48 espécimes amostrados, depositados nos herbários HUESBVC e HVC. Foram registradas 14 espécies para o município, sendo elas: Aphelandra marginata, Clistax speciosus, Dicliptera ciliaris, Justicia laevilinguis, Lepidagathis nemoralis, Poikilacanthus bahiensis, Ruellia bahiensis, R. brevicaulis, R. brevifolia, R. ciliatiflora, R. geminiflora, R. paniculata, Ruellia sp. e Thyrsacanthus ramosissimus. Das espécies coletadas somente D. ciliaris, R. brevifolia e R. paniculata não são endêmicas do Brasil e nove são novos registros para o município. Nossos resultados agregam conhecimento sobre a flora de Vitória da Conquista e, consequentemente, da Bahia e ampliam o acervo dos herbários locais.
CIGARETTE USE, ADDICTION LEVELS, AND INFLUENTIAL FACTORS AMONG HEALTHCARE STUDENTS IN TÜRKİYE
Authors: Avcı Sezer , Coşkun Adnan Batuhan , Çiğdem Zerrin , Dikici Emel , Öztürk Çağlayan Merve , Polat Seray , Arslan Siyabe
Published: June 2024

This study aims to determine cigarette use, addiction levels, and factors influencing cigarette use among university students. A descriptive-cross-sectional study design was employed, and the study procedure was administered to students enrolled in the Health Sciences Faculty (HSF) and Vocational School (VS) of a foundation university in the southern region of Türkiye during the 2022-2023 Academic Fall Semester. The sample of the study consisted of 802 students (255 from VS and 547 from HSF). Data collection was conducted using a ‘Demographic Information Form’ and the ‘Fagerström Test for Nicotine Dependence (FTND).’ It was found that 20.8% of the participating students were cigarette users, and 71.9% initiated cigarette use after the age of 16. Among cigarette users, 34.1% were classified as very mildly addicted, 35.9% as mildly to moderately addicted, and 30.0% as highly and very highly addicted. Considering the results obtained from the Binary Logistic Regression Analysis conducted in this study, being male, having a fragmented family, and having moderate or low academic performance were determined to be factors influencing students’ cigarette use (W = 60.659, p < 0.001; W = 6.076, p = 0.014; W = 10.397, p = 0.001, respectively).
Edukasi Bahaya Merokok pada Remaja SMP N 1 Kemiri, Kecamatan Kemiri, Kabupaten Tangerang
Authors: Insani Bella Khoiriyah , Rachmadini Agisni Kartika , Putri Dhea Angela , Putri Citranda Yofi , Zahra Mayang Ratu , Wijayanti Erlina , Munti Diana Batara
Published: June 2024

Merokok merupakan perilaku berisiko yang menjadi masalah utama dikalangan remaja, tak terkecuali pada siswa SMP Negeri 1 Kemiri Tangerang. Diperlukan edukasi agar remaja memiliki pemahaman yang benar tentang merokok dan dampaknya serta mampu menolak keinginan atau ajakan orang lain untuk merokok. Setelah edukasi dilakukan evaluasi untuk menilai peningkatan pengetahuan dan sikap remaja tentang bahaya merokok. Partisipan meliputi 35 siswa kelas VII-VIII di SMP Negeri 1 Kemiri, Tangerang. Intervensi dilakukan melalui penyuluhan dengan media audiovisual, diskusi kelompok, dan pengembangan media promosi kesehatan dengan melibatkan partisipasi aktif siswa. Hasil menunjukkan peningkatan signifikan pada skor pengetahuan dan sikap setelah intervensi (p<0,001). Rerata skor post-test (98,9 ± 4,7) jauh lebih tinggi dibandingkan rerata skor pre-test (68,0 ± 13,9). Presentase peserta dengan pengetahuan dan sikap baik (skor ≥80) meningkat dari 11,5% menjadi 97,1%. Pendekatan pembelajaran interaktif dan partisipatif terbukti efektif dalam meningkatkan pengetahuan dan sikap remaja tentang bahaya merokok. Namun, kolaborasi multi-sektor dan pendekatan multi-komponen diperlukan untuk memastikan perubahan perilaku yang berkelanjutan. Evaluasi lanjutan diperlukan untuk mengevaluasi dampak jangka panjang intervensi terhadap perilaku merokok pada remaja.
Metabolic Risk Factors in Children with Urinary System Stones
Authors: Çivilibal Mahmut , Çivilibal Ata Mert , Sılay Mesrur Selçuk
Published: June 2024

Objective: To diagnose, treat, and prevent stone recurrence, it is important to determine the metabolic risk factors that play a role in developing urinary system stone disease in children. This study assessed children with urinary system stones’ clinical, radiological, and metabolic characteristics. Material And Methods: A retrospective study was conducted on the records of pediatric patients who applied to our pediatric outpatient nephrology clinic for various reasons between February 2018 and December 2023 and were diagnosed with urinary system stones. Results: Of the 122 patients with a mean age of 4.40±4.16 years (1 month-17 years), 63 (51.6%) were boys and 59 (48.4%) were girls. In 61.4% of the children, a family history was identified. The most common presenting symptom was abdominal/flank pain or restlessness (47.5%). In 25.4% of the patients, the stones were ≤3 mm (microlithiasis), and most stones were in the upper system. One or more metabolic abnormalities have been detected during urine analysis for 58.2% of patients. The most frequent metabolic abnormalities were hypercalciuria (20.5%) and hypocitraturia (17.2%). In 74.6% of patients, the size of stones decreased or completely disappeared with medical treatment based on underlying metabolic abnormalities, and in 17.2%, they did not change at all. Only eight (6.6%) patients required interventional procedures. Conclusion: Metabolic causes should be investigated first in all children with urinary tract stones. Special medical treatments designed to alter metabolism reduce the need for invasive stone procedures.
Analisis Kapasitas Efektif Tampungan Kali Pancir
Authors: Winda Harsanti  , Moh. Zenurianto  , Marjono  , Sitti Safiatus Riskijah  , Ninda Prabawanti
Published: July 2024

Kali Pancir is one of the rivers in Jombang Regency which often experiences flooding. The cause was heavy rain and the critical condition of the embankments. In this research, flood discharge analysis was carried out using synthetic hydrographs and hydraulic modeling for river flow. The data needed is rain data from rain stations around the Pancir River and river profiles. The method used to calculate flood discharge is the Nakayasu Synthetic Unit Hydrograph for 6 different return periods. Simulation using HEC-RAS software is used to simulate flow profiles to determine river cross-sections that are critical to flooding. Based on the results of the calculation analysis, it was found that the peak flood discharge occurred at 3.5 hours. The greater the return period, the greater the river cross section that experiences overflow. At a return period of 1.01 years, the critical cross section starts at STA 45, while at a return period of 50 years, the critical cross section occurs starting at STA 6.
Therapeutic potential of silver nanoparticles from Helianthemum lippii extract for mitigating cadmium-induced hepatotoxicity: liver function parameters, oxidative stress, and histopathology in wistar rats
Authors: Laib Ibtissam , Ali Boutlilis Djahra , Alsalme Ali , Croun David , Bechelany Mikhael , Barhoum Ahmed
Published: June 2024

Introduction: This study explores the therapeutic potential of silver nanoparticles (Ag NPs) synthesized using a Helianthemum lippii extract in mitigating cadmium-induced hepatotoxicity in Wistar rats. Given the increasing environmental and health concerns associated with cadmium exposure, novel and eco-friendly therapeutic strategies are essential.

Methods: Ag NPs were characterized using X-ray diffraction, UV-Vis spectrometry, and energy-dispersive X-ray spectroscopy with scanning electron microscopy, confirming their formation with a cubic crystal structure and particle sizes ranging from 4.81 to 12.84 nm. A sub-acute toxicity study of Ag NPs (2 mg/kg and 10 mg/kg) was conducted, showing no significant difference compared to untreated control rats (n = 3 animals/group). Subsequently, adult Wistar rats (n = 5/group) were divided into a control group and three experimental groups: Ag NPs alone, exposure to 50 mg/kg CdCl2 in drinking water for 35 days, and CdCl2 exposure followed by 0.1 mg/kg/day Ag NPs intraperitoneally for 15 days.

Results: In the CdCl2-exposed group, there was a significant decrease in body weight and increases in alanine and aspartate transaminase levels (p < 0.05 vs. control), indicating hepatotoxicity. Additionally, antioxidant defenses were decreased, and malondialdehyde levels were elevated. Liver histology revealed portal fibrosis, inflammation, necrosis, sinusoid and hepatic vein dilation, and cytoplasmic vacuolations. Treatment with Ag NPs post-CdCl2 exposure mitigated several adverse effects on liver function and architecture and improved body weight.

Discussion: This study demonstrates the efficacy of Ag NPs synthesized via a green method in reducing cadmium-induced liver damage. These findings support the potential of Ag NPs in therapeutic applications and highlight the importance of sustainable and eco-friendly nanoparticle synthesis methods. By addressing both toxicity concerns and therapeutic efficacy, this research aligns with the growing emphasis on environmentally conscious practices in scientific research and healthcare.
Immuno-informatics study identifies conserved T cell epitopes in non-structural proteins of Bluetongue virus serotypes: formulation of a computationally optimized next-generation broad-spectrum multi-epitope vaccine
Authors: Kolla Harish Babu , Dutt Mansi , Kumar Anuj , Hebbandi Nanjunadappa Roopa , Karakach Tobias , Singh Karam Pal , Kelvin David , Clement Mertens Peter Paul , Umeshappa Channakeshava Sokke
Published: July 2024

Introduction

Bluetongue (BT) poses a significant threat to the livestock industry, affecting various animal species and resulting in substantial economic losses. The existence of numerous BT virus (BTV) serotypes has hindered control efforts, highlighting the need for broad-spectrum vaccines.

Methodology

In this study, we evaluated the conserved amino acid sequences within key non-structural (NS) proteins of BTV and identified numerous highly conserved murine- and bovine-specific MHC class I-restricted (MHC-I) CD8+ and MHC-II-restricted CD4+ epitopes. We then screened these conserved epitopes for antigenicity, allergenicity, toxicity, and solubility. Using these epitopes, we developed in silico-based broad-spectrum multiepitope vaccines with Toll-like receptor (TLR-4) agonists. The predicted proinflammatory cytokine response was assessed in silico using the C-IMMSIM server. Structural modeling and refinement were achieved using Robetta and GalaxyWEB servers. Finally, we assessed the stability of the docking complexes through extensive 100-nanosecond molecular dynamics simulations before considering the vaccines for codon optimization and in silico cloning.

Results

We found many epitopes that meet these criteria within NS1 and NS2 proteins and developed in silico broad-spectrum vaccines. The immune simulation studies revealed that these vaccines induce high levels of IFN-γ and IL-2 in the vaccinated groups. Protein-protein docking analysis demonstrated promising epitopes with strong binding affinities to TLR-4. The docked complexes were stable, with minimal Root Mean Square Deviation and Root Mean Square Fluctuation values. Finally, the in silico-cloned plasmids have high % of GC content with > 0.8 codon adaptation index, suggesting they are suitable for expressing the protein vaccines in prokaryotic system.

Discussion

These next-generation vaccine designs are promising and warrant further investigation in wet lab experiments to assess their immunogenicity, safety, and efficacy for practical application in livestock. Our findings offer a robust framework for developing a comprehensive, broad-spectrum vaccine, potentially revolutionizing BT control and prevention strategies in the livestock industry.
A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency
Authors: Chen Celine H. , Crisford Helena , Scott Aaron , Sapey Elizabeth , Stockley Robert A.
Published: July 2024

Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase balance. A sustained imbalance can cause structural changes to the lung parenchyma, leading to emphysema. Predicting and assessing human responses to potential therapeutic candidates from preclinical animal studies have been challenging. Our aims were to develop a more physiologically relevant in vitro model of the proteinase/antiproteinase balance and assess whether the data generated could better predict the efficacy of pharmacological candidates to inform decisions on clinical trials, together with expected biomarker responses.

Methods: We developed an in vitro model assessing the proteinase/antiproteinase balance by the changes in the fibrinogen cleavage products of neutrophil elastase (NE) and proteinase 3 (PR3). This allowed the assessment of physiological and pharmaceutical neutrophil serine proteinase (NSP) inhibitors to determine the putative threshold at which the maximal effect is achieved.

Results: AAT significantly reduced NE and PR3 activity footprints, with the maximal reduction achieved at concentrations above 10 μM. The inhibitor MPH966 alone also significantly reduced NE footprint generation in a concentration-dependent manner, leveling out above 100 nM but had no effect on the PR3 footprint. At levels of AAT consistent with AATD, MPH966 had an additive effect, reducing the NE activity footprint more than either inhibitor alone.

Conclusion: Our results support an inhibitor threshold above which the activity footprint generation appears resistant to increasing dosage. Our model can support the testing of inhibitors, confirming activity biomarkers as indicators of likely pharmaceutical efficacy, the assessment of NSP activity in the pathophysiology of emphysema, and the likely function of biological or pharmacological inhibitors in disease management.
The effect of escitalopram in treating mild to moderate depressive disorder and improving the quality of life in patients undergoing coronary artery bypass grafting – a double-blind randomized clinical trial
Authors: Baradaran Abdolvahab , Ardakani Mohammad Reza Khodaie , Bateni Fatemeh Sadat , Asadian-Koohestani Fatemeh , Vahedi Mohsen , Aein Afsaneh , Shahmansouri Nazila , Sadighi Gita
Published: June 2024

Introduction

Chronic depression and anxiety can be a risk factor for coronary aArtery bypass grafting (CABG) and is an emerging factor after coronary artery disease when the patient is admitted to the hospital and after surgery. We aimed to assess the effect of Escitalopram in treating mild to moderate depressive disorder and improving the quality of life in patients undergoing CABG.

Methods

In this randomized clinical trial, 50 patients undergoing CABG referred to Tehran Heart Hospital from January 2021 to May 2021 and were suffering from mild to moderate depression were randomly assigned to one of the two groups of Escitalopram or placebo. The level of depression was assessed based on Beck’s depression inventory and the quality-of-life status and its domains were assessed based on the SF-36 questionnaire in 2 groups. Measurements were obtained at baseline and at four and eight weeks after treatment. Chi-square, Fisher’s exact, paired, and Wilcoxon tests or ANOVA were used as appropriate.

Results

There was no significant difference between the level of depression between the two study groups at baseline (P=0.312). There was no significant difference between the quality of life and its domains in the two study groups at baseline (P=0.607). However, the most important effect of Escitalopram was reducing depression scores in the intervention group at weeks 4 and 8 after treatment compared to the placebo group (P<0.001). The quality of life and its domains were significantly higher in the Escitalopram group eight weeks after treatment (P=0.004). The amount of drug side effects at 2 and 4 weeks after treatment had no significant difference between the groups (P>0.05).

Conclusion

Escitalopram was effective in treating mild to moderate depressive disorder and improving quality of life in patients undergoing CABG.

Clinical trial registration

https://irct.behdasht.gov.ir/, identifier IRCT20140126016374N2.
Hubungan Perilaku Merokok Konvensional terhadap Saturasi Oksigen pada Pasien General Anestesi di Ruang Intra Anestesi
Authors: Fatimah Fatimah , Elfira Yenni , Irwadi Irwadi , Andriyan Aric Frendi Andriyan , Suherlin Nicen , Habibudin Deka
Published: July 2024

Smoking that causes pathophysiological changes in almost all parts of the lower respiratory tract including lung organs, inhaled cigarette smoke contains harmful chemicals that can damage the immune system of the respiratory tract so that it can cause disorders of the respiratory tract. Some respiratory system disorders such as airway obstruction, or conditions that can result in airway obstruction, airway infections, and other disorders that can inhibit gas exchange. To determine the relationship of smoking behavior to oxygen saturation in general anesthesia patients in the Intra-Anesthesia Room of Level III Hospital Reksodiwiryo Padang. The type of research is quantitative, with a sample size of 34 respondents using purposive sampling technique. Univariate data analysis is presented in the form of a frequency distribution and bivariate analysis using the chi-square test, data processing using the IBM SPSS version 25.0 computer program. The most age is 26-35 years, which is 17 people (50,0%), the most education is high school, which is 16 people (47,1%), the most jobs are traders, which is 10 people (29,4%), the most conventional smoking behavior is heavy smokers, which is 13 people (38,2%), the most oxygen saturation is abnormal, which is 23 people (67,6%), and there is a relationship between smoking behavior and oxygen saturation in general anesthesia patients in the Intra-Anesthesia Room of Level III Hospital, Reksodiwiryo Padang (p = 0,014). The most age is 26-35 years, the most education is high school, the most jobs are traders, the most conventional smoking behavior is heavy smokers, the most oxygen saturation is abnormal and there is a relationship between smoking behavior to oxygen saturation in general anesthesia patients in the Intra-Anesthesia Room of Level III Hospital Reksodiwiryo Padang
Atividade sensível e gênero humano nos Manuscritos econômico-filosóficos de Marx
Authors: Barbosa Pedro Gomes
Published: July 2024

Nesse artigo, buscaremos demonstrar que a constatação das determinações gerais do ser social tornou possível a Marx lidar com o problema da negação do homem na atividade estranhada. Indo à raiz do ser social – tanto ao complexo da individualidade quanto ao “complexo de complexos da universalidade social” –, a crítica ontológica da economia política, iniciada nos Manuscritos econômico-filosóficos, permitiu a Marx, por um lado, demonstrar os problemas da produção capitalista – o estranhamento do homem em relação ao objeto que produz, o estranhamento-de-si e da própria atividade, o estranhamento em relação ao gênero autoproduzido, e o estranhamento em relação aos demais –; e, por outro, tornar explícitas as categorias e determinações mais gerais do ser social.
Análise de produções científicas realizadas nos últimos 20 anos sobre resíduos sólidos urbanos na RevBEA
Authors: Santos Erick Menezes dos , Teixeira Francielle Goncalves , Santiago Gabriela Tavares , Santos José Mateus Santana
Published: July 2024

O presente projeto é uma iniciativa da unidade curricular Educação Ambiental, da Universidade Federal do São Paulo (Unifesp), em que se propõem avaliar a relevância contextual com a qual os Resíduos Sólidos Urbanos (RSU) serviram de temáticas discutidas e publicadas na Revista Brasileira de Educação Ambiental (RevBEA) entre 2004 e 2023, de maneira a dissertar sobre como os RSU ainda continuam sendo pautas de políticas públicas negligenciadas em dimensão política, educacional e socioambiental, além de apontar avanços mínimos na literatura que, por vezes, apenas aprofunda as problemáticas do RSU, reduzindo-os aos lixos, à coleta seletiva e à consciência ambiental.
Educação Ambiental não formal: principais publicações da Revista Brasileira de Educação Ambiental
Authors: Rezende Andressa Basile , Rocha Ana Luiza Amaral , Lodi Cecília Monteiro dos Santos , Silva Kayo Ferreira da
Published: July 2024

O presente artigo objetivou a análise das publicações da Revista Brasileira de Educação Ambiental na temática de Educação Ambiental não formal. Realizamos um levantamento de todos os artigos presentes na revista e produzimos uma análise de dados baseado na localidade do projeto, público-alvo, tipo de atividade entre outras características. Vemos através dos dados que a Educação Ambiental no Brasil está se expandindo e diversificando, com uma variedade de abordagens sendo adotadas para atender às necessidades específicas de diferentes regiões e os tipos de atividades realizadas e o público-alvo dos projetos de Educação Ambiental fornece uma visão abrangente sobre a evolução e o foco dessas iniciativas.
Turizm Rehberliği Bölümlerinin Müfredatlarında Yer Alan Gastronomi ile İlgili Derslerin İncelenmesi
Authors: Sandıkcı Mustafa , Albayrak Aybike Nur
Published: June 2024

Amaç ve Önem: Araştırmanın amacı Türkiye’de lisans düzeyinde eğitim veren Turizm Rehberliği bölümlerinin müfredatlarında yer alan gastronomi ile ilişkili derslerin tespit edilerek incelenmesidir. Bu amaç doğrultusunda araştırma, araştırma evreninin tamamına erişim sağlanması ve güncel veriler ile daha ayrıntılı bir durum tespiti yapılması açısından önem taşımaktadır.

Yöntem: Türkiye’de bulunan devlet ve vakıf üniversitelerinin fakülte ve yüksekokullarının bünyesinde lisans eğitimi veren Turizm Rehberliği bölümü müfredatları araştırmanın evrenini oluşturmaktadır. Araştırma verilerini elde edebilmek için ikincil verilerden yararlanılmıştır. Bu kapsamda nitel bir veri analiz yöntemi olan doküman analizi kullanılmıştır. İlgili dokümanları incelemek için öncelikle Yüksek Öğretim Kurulu (YÖK) Program Atlası verileri kullanılmıştır. Elde edilen veriler frekans ve yüzde dağılımlarıyla sunulmuştur.

Bulgular: Araştırma kapsamında Türkiye’de lisans eğitimi veren 38 devlet ve vakıf üniversitelerinin turizm rehberliği bölümlerinin müfredatları incelenmiştir. Turizm rehberliği bölümlerinin sırasıyla Turizm Fakültelerinde, Uygulamalı Bilimler Yüksekokullarında, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Turizm İşletmeciliği ve Otelcilik Yüksekokulu ve Turizm ve Otelcilik Yüksekokullarında eğitim verdiği tespit edilmiştir. Turizm rehberliği bölümlerinin müfredatlarında gastronomi ile ilişkili toplam 95 ders tespit edilmiştir. İlgili müfredatlarda en sık tespit edilen derslerin sırasıyla “Türk Mutfağı/Türk Mutfak Kültürü/Türkiye’nin Mutfak Kültürü”, “Dünya Mutfağı/Dünya Mutfak Kültürleri/Dünya Mutfak Kültürü/Dünya Mutfakları/Uluslararası Mutfaklar/Uluslararası Yemek Kültürü” ve “Türk ve Dünya Mutfağı/Türk ve Dünya Mutfakları/Türk ve Dünya Mutfak Kültürü” dersleri olduğu sonucuna ulaşılmıştır. Bu derslerin %66,7’sinin seçmeli, %25,3’ünün ortak alan seçmeli ve %8,1’inin ise zorunlu ders kategorisinde yer aldığı tespit edilmiştir.

Özgünlük/Bilimsel Katkı: Araştırmanın mevcut literatüre güncel verilerle katkı sağlayacağı düşünülmektedir.

Sınırlılıklar: Araştırma kapsamında yalnızca Türkiye’de lisans düzeyinde eğitim veren Turizm Rehberliği bölümleri ele alınmıştır. Ön lisans ve lisansüstü Turizm Rehberliği bölümleri araştırmaya dahil edilmemiştir.
Innovación incluyente en educación
Authors: Rivas Luis Rodolfo Ibarra
Published: June 2024

Esta aportación ofrece resultados parciales de una investigación. Propone transitar de aquí (lo conocido/ignorado docente-estudiantil), al allá (los conocimientos científicos) y avizorar un más allá (lo cognoscible-innovación- creación). Conocimiento-conocer son productos y procesos inacabados. Para comprenderlos se siguió el método inherente a la complejidad. Algunos hallazgos son: relaciones entre teorías administrativas, de gestión y de la gobernanza: nexos entre formas de organización laboral y tipo de sociedad; por ejemplo, Taylor-Fayol (división funcional y mando técnico-vertical) y la sociedad norteamericana muy segmentada. Ishikawa-Deming (círculos de calidad) y una sociedad más eficiente y digna. Bulkeley y Betsill (gobernanza) y promover democratización y cuidado del medio. Concluye ofreciendo preguntas que tensan un aquí que requiere transladarse a un allá y abrir un más allá. La labor educativa estriba en llevar el conocer-conocimiento, de estudiantes, del grupo y docente (aquí) a un allá y, luego, un más allá. Aquí es el estado actual del conocer-conocimiento común y conocimiento de sentido común científico. Allá es el avance científico en sí. Más allá es lo proyectable: estar abierto al futuro, a crear el porvenir-inédito. Los maestros, al transitar, propiciarán inclusión ambiental-social-grupal-individual.