bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable food systems education in nutrition and dietetics: an appraisal of the tertiary landscape in multiple countries
Authors: Wegener Jessica , Carlsson Liesel , Barbour Liza , Everitt Tracy , Pettinger Clare , Reguant-Closa Alba , Meyer Nanna , Svette Sean , Hassan Dareen , Platnar Jillian
Published: August 2024

Purpose

Despite a growing awareness of the gap between professional expectations and competence, there has been no comprehensive appraisal of sustainable food systems (SFS) education within dietetics and nutrition programs to date. Dietitians and nutritionists play important roles in promoting sustainability yet many perceive themselves to be inadequately trained. The purpose of this study was to explore how, and to what degree, SFS education is incorporated into accredited nutrition and dietetics programs in the United Kingdom, Australia and Canada.

Design/methodology/approach

A content analysis of course descriptions from program websites was conducted between 2021 and 2022. Courses were reviewed, analyzed and evaluated using a novel sustainability metric.

Findings

SFS is integrated into the education environment of some, but not all, dietetics and nutrition programs to varying degrees (no, partial and full). Partial and full integration was present in a small percentage of courses, with a larger percentage in nutrition programs. SFS education was offered more often through a single unit than a dedicated course. Twelve best practice examples of courses dedicated to SFS were identified. In the UK, their focus was nutrition and diet, contrasting food and food systems in Australia and Canada.

Originality/value

These findings provide insight into SFS education for professional societies, instructors and program directors. Through intentional curricular design considerations supported by this study, program leads can take small conscious reorganizational steps to integrate SFS. This study offers a sound methodology to initiate and benchmark further assessment and a novel approach for other professions looking to equip their future workforce through SFS education.
Effect of load on the tribological properties of Si3N4-based composite with N-GQDs
Authors: Chen Wei , Ma Yucheng , Liu Xingyu , Xu Enguang , Yang Wenlong , Jia Junhong , Lou Rui , Zhu Chaolong , Wu Chenjing , Zhao Ziqiang
Published: August 2024

Purpose

The purpose of this paper is to improve the mechanical and tribological properties of Si3N4 ceramics and to make the application of Si3N4 ceramics as tribological materials more extensive.

Design/methodology/approach

Si3N4-based composite ceramics (SN-2L) containing nitrogen-doped graphene quantum dots (N-GQDs) were prepared by hot press sintering process through adding 2 Wt.% nanolignin as precursor to the Si3N4 matrix, and the dry friction and wear behaviors of Si3N4-based composite against TC4 disc were performed at the different loads by using pin-on-disc tester.

Findings

The friction coefficients and wear rates of SN-2L composite against TC4 were significantly lower than those of the single-phase Si3N4 against TC4 at the load range from 15 to 45 N. At higher load of 45 N, SN-2L/TC4 pair presented the lowest friction coefficient of 0.25, and the wear rates of the pins and discs were as low as 1.76 × 10−6 and 2.59 × 10−4mm3/N·m. The low friction and wear behavior could be attributed to the detachment of N-GQDs from the ceramic matrix to the worn surface at the load of 30 N or higher, and then an effective lubricating film containing N-GQDs, SiO2, TiO2 and Al2SiO5 formed in the worn surface. While, at the same test condition, the friction coefficient of the single-phase Si3N4 against TC4 was at a range from 0.45 to 0.58. The spalling and cracking morphology formed on the worn surface of single-phase Si3N4, and the wear mechanism was mainly dominated by adhesive and abrasive wear.

Originality/value

Overall, a high-performance green ceramic composite was prepared, and the composite had a good potential for application in engineering tribology fields (such as aerospace bearings).

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-05-2024-0161/
Resilience of developing economies to external shocks: empirical evidence from CEMAC countries
Authors: Foabeh Peter Ajonghakoh , Aumeboonsuke Vesarach
Published: August 2024

Purpose

This study aims to investigate the effects of three significant events – the 1994 CFA currency depreciation, the 2008 Global Financial Crisis (GFC), and instances of political coups – on the relationships between FDI inflow, economic growth, and governance within the Central African Economic and Monetary Community (CEMAC) countries. It seeks to evaluate how these events influence the linkages between FDI, economic growth, and governance, to aid the understanding of responses to external shocks and internal political disruptions.

Design/methodology/approach

The study employs a panel Vector Autoregression (VAR) analysis using data from 1990 to 2019 by exploring the dynamic relationships among FDI inflow, economic growth, and aggregate governance indicators within the CEMAC sub-region. The analysis was conducted utilizing the EViews software package, facilitating robust examination through the introduction of the Bayesian VAR to facilitate the interpretation of parameters and the data.

Findings

The results indicate that, contrary to initial hypotheses, growth and governance do not emerge as determinants for attracting FDI within the CEMAC sub-region. However, governance stands out as a crucial determining factor for economic growth. Furthermore, the study suggests that the 1994 CFA currency depreciation, the 2008 GFC, and instances of political coups did not significantly impact FDI, growth, and governance within these countries. Despite the potential vulnerability of the CEMAC countries to external shocks, the effects of these events on the dynamics of FDI, economic growth, and governance were not apparent. Notably, political instability, as evidenced by coups, emerges as a significant factor shaping the interactions between FDI, growth, and governance in CEMAC countries.

Research limitations/implications

These findings have significant implications for policymakers and stakeholders in the CEMAC countries. Understanding that governance has a central role in driving economic growth places great importance of prioritizing governance reforms to foster sustainable development. Moreover, the identification of political instability as a key determinant affecting the relationships between FDI, growth, and governance emphasizes the need for political stability and effective governance structures to attract and sustain FDI inflows as well as foster economic growth.

Originality/value

This study contributes to the existing literature by offering insights into the linkages between FDI, economic growth, governance, and external shocks within the CEMAC sub-region. By examining the specific impacts of the 1994 CFA currency depreciation, the 2008 GFC, and political coups on these dynamics, the study provides original perspectives on the resilience of CEMAC countries to external and internal disruptions.
The Indonesian youth tourist motivation intention to visit Phuket: a post Covid-19 study with the moderating role of health risk using SPSS PROCESS macro (Model 1)
Authors: Soonsan Nimit , Jumani Zulfiqar Ali , Thongmun Sarayute , Sangthong Suphattra
Published: August 2024

Purpose

There are two goals for this study. Firstly, this study aims to understand the impact of various youth tourist motivations, such as Muslim amenities, Islamic product travel, attraction, perceived value and service quality, on the intention to visit Phuket. Secondly, this study aims to determine whether or not young people's perceptions of health risks influence their motivations and decisions to travel to Phuket in the wake of the COVID-19 pandemic.

Design/methodology/approach

This study used a quantitative methodology, using nonprobability convenience sampling to collect responses from 249 Indonesian youths who intended to visit Phuket after the COVID-19 pandemic. Hayes' (2018) SPSS PROCESS macro (Model 1) was used to test the research model.

Findings

The findings showed that the intention to travel was significantly affected by factors such as Muslim amenities, Islamic product travel, attraction, perceived value and service quality. Furthermore, the perceived health risk moderated three dimensions of Islamic product travel, perceived value and service quality on intention to visit.

Research limitations/implications

This study is limited to a sample of Indonesian youth tourists and the impacts of motivation (Muslim amenities, Islamic product travel, attractiveness, perceived value and service quality) and the moderating influence of health risk on the desire to visit Phuket.

Originality/value

This study sheds insight into the influence of several young tourists' motives on the intention to visit Phuket and the moderating role of perceived health risks. The findings provide essential insights for marketing strategies and the development of the international destination. Specifically, the study suggests developing products with Islamic attributes, emphasising the attraction factor and improving perceived values. The study also provides a model that demonstrates how religious values can affect an individual's decision-making process.
The moderating effect of organizational knowledge utilization on top management team’s social capital and the innovation quality of high-tech firms
Authors: Duan Yunlong , Wang Kun , Chang Hong , Liu Wenjing , Xie Changwen
Published: August 2024

Purpose

This paper aims to investigate the following issues: the mechanisms through which different types of top management team’s social capital influence the innovation quality of high-tech firms, and the moderating effect of organizational knowledge utilization on the relationship between top management team’s social capital and innovation quality in high-tech firms.

Design/methodology/approach

This study categorizes top management team’s social capital into political, business and academic dimensions, investigating their impact on innovation quality in high-tech firms. Furthermore, a research model is developed with organizational knowledge utilization as the moderating variable. Data from Chinese high-tech firms between 2010 and 2019 are collected as samples for analysis.

Findings

The innovation quality of high-tech firms shows an inverted U-shaped trend as the top management team’s political capital and business capital increase. The top management team’s academic capital has a significantly positive correlation with the innovation quality of high-tech firms. Moreover, organizational knowledge utilization plays a significant moderating role in the relationship between the top management team’s social capital and innovation quality in high-tech firms.

Originality/value

This study explores the relationship among different dimensions of top management team’s social capital, innovation quality and organizational knowledge utilization. It holds significant theoretical value in enriching and refining the interactions between top management team’s social capital, knowledge management theory and innovation management theory. In addition, it offers important practical implications for firms to rationally approach top management team’s social capital, emphasize top management team configuration management and establish a comprehensive and efficient organizational knowledge utilization mechanism.
Examining public intentions and attitudes toward solar rooftop panel adoption in Indian residences: an integration of TPB, DOI and UTAUT
Authors: Anjum Aqsa , Subhan Mohammad
Published: August 2024

Purpose

The study investigates the intention of adopting solar panels and incorporating renewable energy sources into the electrical mix, providing insightful information on the nuances of this critical topic.

Design/methodology/approach

The study used online and offline surveys to gather information on rooftop solar panels from Indian homes. To get reliable findings, the collected responses were analyzed using structural equation modeling using Smart PLS version 3.5 and SPSS version 23.0.

Findings

The research examines sustainability difficulties, psychological issues and demographic considerations, yielding a variety of conclusions. Low compatibility and high perceived cost have a detrimental influence on adoption intentions, emphasizing the importance of integrating consumer perceptions with technology while addressing cost concerns. Conversely, relative advantage, awareness, environmental concern, facilitating conditions and observability positively influenced the adoption.

Practical implications

The study underscores the importance of highlighting benefits, raising awareness, providing necessary resources and showcasing visible instances of technology use. By revealing the connection between different factors, the study offers a roadmap for policymakers and stakeholders to accelerate the transition toward sustainable energy practices.

Originality/value

To the best of the authors' knowledge, this study is one of the first to propose an integration of the Theory of Planned Behavior (TPB), the Diffusion of Innovations Theory (DOI) and the Unified Theory of Acceptance and Use of Technology (UTAUT), alongside various independent variables. The research offers a comprehensive perspective on factors that facilitate and obstruct the usage of solar energy.
Deciphering misinformation and disinformation: insights from structural coupling and penetration
Authors: Sohn YJ , Edwards Heidi Hatfield , Petersen Theodore
Published: August 2024

Purpose

This paper aims to enhance the understanding of the distinct origins, mechanisms, growth paths and societal impacts of misinformation and disinformation through the theoretical lens of Niklas Luhmann’s social systems theory, particularly focusing on structural coupling and penetration.

Design/methodology/approach

This paper is based on a conceptual study that investigates the phenomena of mis-/disinformation based on reviews of the literature on social systems theory, particularly focusing on structural coupling and penetration.

Findings

This theoretical analysis has led to the postulations that mis-/disinformation would cause social conflicts through divergent routes and that they do not necessarily have negative consequences in society. That is, conflicts or communication of contradictions serve for the reproduction and change in social systems and, furthermore, serve society as an immune mechanism. We speculate that similarities in the manifestation of mis-/disinformation could stem from the influence of amplifiers, such as moral intervention. Nevertheless, we posit that disinformation stemming from intentional penetration is more likely to cause societal dysfunction than misinformation, leading to conflict overload, polarized information ecosystems and potential system failures.

Originality/value

It provides a broader theoretical perspective for a better understanding of the roots and mechanisms of mis-/disinformation and their social consequences. It also engages with unresolved debates over structural couplings and penetration, showing how distinguishing these concepts enhance analytical clarity and explanatory power.
Machine learning insights: probing the variable importance of ex-ante information
Authors: Albada Ali , Abusham Eimad Eldin , Ong Chui Zi , Al Qatiti Khalid
Published: August 2024

Purpose

Empirical examinations of initial public offering (IPO) initial returns often rely heavily on linear regression models. However, these models can prove inefficient owing to their susceptibility to outliers, a common occurrence in IPO data. This study introduces a machine learning method, known as random forest, to address issues that linear regression may struggle to resolve.

Design/methodology/approach

The study’s sample comprises 352 fixed-priced IPOs from the year 2004 until 2021. A unique aspect of this research is its application of the random forest method. The accuracy of random forest in comparison to other methods is evaluated. The findings indicate that the random forest model significantly outperforms other methods in all of the evaluated aspects.

Findings

The variable importance measure indicates that investors’ demand, divergence of opinion among investors and offer price are the most crucial predictors of IPO initial returns. These determinants hold particular significance due to the widespread use of the fixed-price method in Malaysia, as this method amplifies the information asymmetry in the IPO market.

Originality/value

To the best of the authors’ knowledge, this study is among the pioneering works in Malaysian literature to apply the random forest method to address the constraints of conventional linear regression models. This is achieved by considering a more extensive array of factors and acknowledging the influence of outliers. Additionally, this study adds value to Malaysian literature by ranking and identifying the ex-ante information that best signals the issuing firm’s quality. This contribution facilitates prospective investors’ decision-making processes and provides issuing firms with effective means to communicate their value and quality to the IPO market.
Multimaterial additive manufacturing of poly-L-lactic acid– hydroxylapatite/graphene oxide scaffold fabricated via vat photopolymerization: experimental investigation, analysis and cell study
Authors: Ghaderi Iman , Behravesh Amir Hossein , Hedayati Seyyed Kaveh , Alavinasab Ardebili Seyed Alireza , Kordi Omid , Rizvi Ghaus , Gholivand Khodayar
Published: August 2024

Purpose

This study aims to design and implement a multimaterial system for printing multifunctional specimens suitable for various sectors, with a particular focus on biomedical applications such as addressing mandibular bone loss.

Design/methodology/approach

To enhance both the mechanical and biological properties of scaffolds, an automatic multimaterial setup using vat photopolymerization was developed. This setup features a linear system with two resin vats and one ultrasonic cleaning tank, facilitating the integration of diverse materials and structures to optimize scaffold composition. Such versatility allows for the simultaneous achievement of various characteristics in scaffold design.

Findings

The printed multimaterial scaffolds, featuring 20 Wt.% hydroxylapatite (HA) on the interior and poly-L-lactic acid (PLLA) with 1 Wt.% graphene oxide (GO) on the exterior, exhibited favorable mechanical and biological properties at the optimum postcuring and heat-treatment time. Using an edited triply periodic minimal surface (TPMS) lattice structure further enhanced these properties. Various multimaterial specimens were successfully printed and evaluated, showcasing the capability of the setup to ensure functionality, cleanliness and adequate interface bonding. Additionally, a novel Gyroid TPMS scaffold with a nominal porosity of 50% was developed and experimentally validated.

Originality/value

This study demonstrates the successful fabrication of multimaterial components with minimal contaminations and suitable mechanical and biological properties. By combining PLLA-HA and PLLA-GO, this innovative technique holds significant promise for enhancing the effectiveness of regenerative procedures, particularly in the realm of dentistry.
Preoperative definition and new concept design of 3D printed buttress model to seal skull base after endoscopic endonasal surgery
Authors: Papallo Ida , Solari Domenico , Onofrio Ilaria , Ugga Lorenzo , Cuocolo Renato , Martorelli Massimo , Russo Teresa , Bove Ilaria , Cavallo Luigi Maria , Gloria Antonio
Published: August 2024

Purpose

This study aims to integrate design methods and additive manufacturing with the use of a thermoplastic elastomer certified for medical use and reverse engineering towards a new concept of a customized buttress model with optimized features for the reconstruction of the osteo-dural opening after endoscopic endonasal transtuberculum-transplanum approach.

Design/methodology/approach

Additive manufacturing allows making of cost-effective and useable devices with tailored properties for biomedical applications. The endoscopic endonasal approach to the suprasellar area enables the management of different intradural tumours, and the craniectomy at the skull base is generally wide and irregular. Defining an optimal strategy for osteodural defect closure at the preoperative stage represents a significant challenge.

Findings

Using the results obtained from a computed tomography analysis, skull base defects were designed to plan the surgical approach. Several concepts of customized buttress models were first built up, initially focusing on thin, flexible edges characterized by different thicknesses. Finite element analyses and design optimization allowed us to achieve the optimal design solution with improved compliance/flexibility for easy intranasal manoeuvrability, maintaining an adequate mechanical stability. As the thickness of the edges decreased, an increase of strain energy values was found (i.e. 1.2 mJ – Model A, 1.7 mJ – Model B, 2.3 mJ – Model C, 4.3 mJ – Model D). However, a further optimization (Model E) led to a significant increase of the compliance (strain energy of 14.1 mJ).

Originality/value

The results obtained from clinical evaluations demonstrated the feasibility of the proposed technical solutions, improving surgery effectiveness.
Neighbourhood diversity effects on insect herbivory: Plant leaf traits mediate associational resistance
Authors: Wang Zhenyu , Feng Lixuan , Frew Adam , Lu Anqi , Yu Zaipeng , Huang Zhiqun
Published: August 2024

The vulnerability of trees to insect herbivory can be influenced by forest structure and diversity. Associational resistance theory posits that trees surrounded by diverse neighbours are likely to suffer reduced herbivory. However, the underlying mechanisms of this effect are debated, with accumulating evidence suggesting that leaf traits could mediate the strength and direction of the diversity‐herbivory relationships.

To determine the role of tree trait variation in mediating this relationship, we measured leaf herbivory and nine morphological and nutritional leaf traits known to influence herbivory on 394 focal trees of twelve species cultivated in monocultures and mixtures of four, eight, and sixteen species in a 4‐year‐old large‐scale manipulated tree diversity experiment.

A reduction in the proportion of focal trees in species‐rich neighbourhoods resulted in increased leaf carbon: nitrogen ratio of focal trees, which mediated a reduction in insect herbivory. Moreover, an increase in plant height apparency, defined as the disparity in total height between a focal tree and its closest neighbours, indirectly amplified herbivory by reducing leaf phosphorus concentration.

Synthesis: The study suggests that neighbourhood diversity and physical structure can indirectly affect herbivory on a focal plant by modifying its leaf trait. Accounting for the functional differences between forests could enhance our understanding of diversity–herbivory relationships.
Inclusive education in Zimbabwe: An assessment of teachers' self‐efficacy and attitudes in Masvingo
Authors: Chitiyo Jonathan , Simone Kinsey , Muresherwa Edson , Chitiyo George , Chitiyo Morgan
Published: August 2024

Since the Salamanca Statement and Framework for Action in 1994, many countries have been advancing their education systems towards inclusive education. Zimbabwe, being one of the signatories to this framework, is one of the countries that have embraced the concept of inclusive education and has since been making strides towards its advancement albeit rather slowly. The purpose of this descriptive correlational study was to examine the self‐efficacy levels of Zimbabwean primary, secondary and high school teachers with inclusive education, as well as their attitudes towards the practice. To do this, 100 primary, secondary and high school teachers working in inclusive school settings in the Masvingo province were surveyed using a modified version of the Inclusion Competencies of Sri Lankan Teachers, (ICSLT) instrument. Findings of this study indicated that most of the participating teachers were in support of inclusive education despite not having the requisite preparation to implement it. Based on the findings, specific recommendations are provided for improving preservice teacher preparation and professional development for in‐service teachers in support of inclusive education.
Embracing complexity in plant–microbiome systems
Authors: Poupin María Josefina , González Bernardo
Published: August 2024

Despite recent advances in understanding the role of microorganisms in plant holobiont metabolism, physiology, and fitness, several relevant questions are yet to be answered, with implications for ecology, evolution, and sustainable agriculture. This article explores some of these questions and discusses emerging research areas in plant microbiomes. Firstly, it emphasizes the need to move beyond taxonomic characterization towards understanding microbial functions within plant ecosystems. Secondly, controlling methodological biases and enhancing OMICS technologies' standardization is imperative for a deeper comprehension of plant–microbiota interactions. Furthermore, while plant microbiota research has primarily centred on bacteria and fungi, other microbial players such as archaea, viruses, and microeukaryotes have been largely overlooked. Emerging evidence highlights their presence and potential roles, underscoring the need for thorough assessments. Future research should aim to elucidate the ecological microbial interactions, their impact on plant performance, and how the plant context shapes microbial community dynamics. Finally, a discussion is provided on how the multiple layers of abiotic and biotic factors influencing the spatiotemporal dynamics of plant–microbiome systems require in‐depth attention. Examples illustrate how synthetic communities and computational methods such as machine learning and artificial intelligence provide alternatives to tackle these challenges and analyse the plant holobiont as a complex system.
Deciphering microbial communities involved in marine steel corrosion using high‐throughput amplicon sequencing
Authors: Shibulal Biji , Smith Martin Peter , Cooper Ian , Burgess Heidi Marie , Moles Norman , Willows Alison
Published: August 2024

To characterize the source and effects of bacterial communities on corrosion of intertidal structures, three different UK coastal sites were sampled for corrosion materials, sediment and seawater. Chemical analyses indicate the activity of sulfate‐reducing microbes (SRBs) at 2 sites (Shoreham and Newhaven), but not at the third (Southend‐on‐Sea). Microbial communities in the deep sediment and corrosion samples are similar. The phylum Proteobacteria is dominant (40.4% of the total ASV), followed by Campilobacterota (11.3%), Desulfobacterota and Firmicutes (4%–5%). At lower taxonomic levels, corrosion causing bacteria, such as Shewanella sp. (6%), Colwellia sp. (7%) and Mariprofundus sp. (1%), are present. At Southend‐on‐sea, the relative abundance of Campilobacterota is higher compared to the other two sites. The mechanism of action of microorganisms at Shoreham and Newhaven involves biogenic sulfuric acid corrosion of iron by the combined action of SRBs and sulfur‐oxidizing microbes. However, at Southend‐on‐sea, sulfur compounds are not implicated in corrosion, but SRBs and other electroactive microbes may play a role in which cathodic reactions (electrical MIC) and microbial enzymes (chemical MIC) are involved. To contribute to diagnosis of accelerated intertidal corrosion types, we developed a rapid identification method for SRBs using quantitative polymerase chain reaction high‐resolution melt curve analysis of the dsrB gene.
Digital phenotypes of real‐time suicidal ideation: Correlates and consequences
Authors: Kivelä L. M. M. , van der Does A. J. W. , Gilissen R. , Antypa Niki
Published: August 2024

Introduction

Suicidal ideation variability refers to within‐day fluctuations in suicidal ideation, and has recently been proposed as an indicator of suicide risk. However, not much is known yet about its correlates and clinical relevance.

Methods

We examined characteristics of real‐time suicidal ideation using Ecological Momentary Assessment in 82 individuals with current active suicidal ideation. Data were collected four times daily over 21 days. Latent profile analysis was used to identify subtypes of suicidal ideation. We further examined sociodemographic and clinical correlates of the profiles, and their association with the occurrence of suicide attempts during a 1‐year follow‐up.

Results

We identified three “digital” phenotypes of suicidal ideation that differed on the frequency, intensity and variability of ideation. The profiles were: high frequency, high intensity, moderate variability (Phenotype 1), moderate/high frequency, moderate intensity, high variability (Phenotype 2), and moderate frequency, low intensity, low variability (Phenotype 3). Phenotypes 1 and 2 were associated with a worse clinical profile at baseline (higher suicidal ideation and depressive symptom severity), and increased odds of suicide attempt during follow‐up, compared to Phenotype 3. Phenotype 1 was further characterized by repeated suicidal behavior.

Conclusions

Two phenotypes of real‐time suicidal ideation were identified that appear to confer a higher risk of suicidal behavior in the near future (12 months). These phenotypes were characterized by higher variability of suicidal ideation—and also higher intensity and frequency of ideation. Considering the small sample size, the clinical usefulness of the profiles remains to be demonstrated.
Using EPIWATCH® open‐source surveillance to describe the epidemiology of lumpy skin disease outbreaks in South and Southeast Asia (2022–2023)
Authors: Hutchinson D , Li B , Lim S , Stone H , MacIntyre CR
Published: August 2024

Lumpy skin disease (LSD) poses a significant threat to animal welfare and leads to economic losses in affected countries. LSD outbreaks may also impact trade and regional relationships. South and Southeast Asia, with its dense livestock population and intricate trade networks, are susceptible to LSD outbreaks. Indonesia confirmed its first LSD cases in March 2022, leading to substantial livestock losses by August 2023. Australia, an important player in the global beef industry, faced trade disruptions due to LSD concerns raised by Indonesia and Malaysia, claims that were refuted by Australian authorities. The dispute highlights the need for good surveillance. EPIWATCH®, employing artificial intelligence, provides real‐time outbreak signals, and spatial analysis can identify LSD hotspots, leading to timely interventions. This study uses data collected by the EPIWATCH® open‐source disease surveillance system at the University of New South Wales in 2022 and 2023 and compares it for timeliness and completeness with data available on the World Animal Health Information System (WAHIS). We found more timely reports of LSD outbreaks in EPIWATCH® compared to WAHIS. In conclusion, open‐source surveillance tools like EPIWATCH® can provide timely alerts of disease emergence, such as LSD outbreaks in South and Southeast Asia, which can supplement formal reporting systems.
Clinical pharmacology in adolescent transgender medicine
Authors: Cirrincione Lauren R. , Huang Kai J. , Sequeira Gina M.
Published: August 2024

Adolescent transgender medicine is a growing clinical field. Gender‐affirming medications for transgender youth may include gonadotropin‐releasing hormone (GnRH) agonists, gender‐affirming hormones or both. To evaluate the potential effects of GnRH agonists (puberty suppression) on pharmacokinetic processes for transgender youth, we searched PubMed from inception to May 2024 for publications on the effects of GnRH agonists on drug absorption, distribution, metabolism or excretion for transgender adolescents or effects on hormones (including gonadotropins, adrenal androgens, sex steroids) that are associated with changes in drug metabolism during puberty in the general adolescent population. No publications discussed the effects of GnRH agonist treatment on pharmacokinetic processes for adolescent transgender people. Sixteen publications observed marked decreases in gonadotropins and sex steroids for both adolescent transgender men and adolescent transgender women and slight effects on adrenal androgens. During GnRH agonist treatment, changes in body composition and body shape were greater for adolescent transgender people than for cisgender adolescent people. Further research is needed to better understand the effects of GnRH agonists on drug metabolism and other pharmacokinetic processes for transgender adolescents receiving GnRH agonists and other gender‐affirming medications.
Sensitisation to the acrylate co‐polymers glyceryl acrylate/acrylic acid co‐polymer, sodium polyacrylate and acrylates/C10‐30 alkyl acrylate cross‐polymer (Carbopol®) is rare
Authors: Soriano Livia F. , Chowdhury M. M. U. , Cousen Philippa , Dawe Simon , Ghaffar Sharizan A. , Haworth Adam , Holden Catherine R. , Hollywood Aoife , Johnston Graham A. , Kirk Stephen , Mughal Avad A. , Orton David I. , Parker Robin , Rajeev Asha , Scharrer Krisztina , Sinha Aparna , Stone Natalie M. , Thompson Donna , Wakelin Sarah , Whitehouse Heather , Wootton Catriona , Buckley Deirdre A.
Published: August 2024

Background

Acrylate polymers and cross‐polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly‐used ACPs.

Objectives

The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co‐polymer, sodium polyacrylate, and acrylates/C10‐30 alkyl acrylate cross‐polymer (Carbopol®).

Materials and Methods

The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co‐polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10‐30 alkyl acrylate cross‐polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded.

Results

In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co‐polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®.

Conclusions

Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate‐sensitised patients by exposure to these three ACPs appears unlikely.
TFAP2A Activates S100A2 to Mediate Glutamine Metabolism and Promote Lung Adenocarcinoma Metastasis
Authors: Zeng Tao , Ren Wangsheng , Zeng Hang , Wang Dachun , Wu Xianyu , Xu Guo
Published: August 2024

Background

Lung adenocarcinoma (LUAD) is a fatal disease with metabolic abnormalities. The dysregulation of S100 calcium‐binding protein A2 (S100A2), a member of the S100 protein family, is connected to the development of various cancers. The impact of S100A2 on the LUAD occurrence and metastasis, however, has not yet been reported. The functional mechanism of S100A2 on LUAD cell metastasis was examined in this article.

Methods

The expression of TFAP2A and S100A2 in LUAD tissues and cells was analyzed by bioinformatics and qRT‐PCR, respectively. The enrichment pathway analysis was performed on S100A2. Bioinformatics analysis determined the binding relationship between TFAP2A and S100A2, and their interaction was validated through dual‐luciferase and chromatin immunoprecipitation experiments. Cell viability was determined using cell counting kit‐8 (CCK‐8). A transwell assay was performed to analyze the invasion and migration of cells. Immunofluorescence was conducted to obtain vimentin and E‐cadherin expression, and a western blot was used to detect the expression of MMP‐2, MMP‐9, GLS, and GLUD1. The kits measured the NADPH/NADP ratio, glutathione (GSH)/glutathione disulfide (GSSG) levels, and the contents of glutamine, α‐KG, and glutamate.

Results

S100A2 was upregulated in LUAD tissues and cells, and S100A2 mediated glutamine metabolism to induce LUAD metastasis. Additionally, the transcriptional regulator TFAP2A was discovered upstream of S100A2, and TFAP2A expression was upregulated in LUAD, which indicated that TFAP2A promoted the S100A2 expression. The rescue experiment found that upregulation of S100A2 could reverse the inhibitory effects of silencing TFAP2A on glutamine metabolism and cell metastasis.

Conclusion

In conclusion, by regulating glutamine metabolism, the TFAP2A/S100A2 axis facilitated LUAD metastasis. This suggested that targeting S100A2 could be beneficial for LUAD treatment.
Whole‐Exome Sequencing and Experimental Validation Unveil the Roles of TMEM229A Q200del Mutation in Lung Adenocarcinoma
Authors: Liang Yi‐Xian , Xie Yan‐Ping , Yu Huan‐Ming , Zhu Wen‐Juan , Yin Cheng‐Yi , Dong Zhao‐Hui , Zhang Xi‐Lin
Published: August 2024

Introduction

Lung adenocarcinoma (LUAD) is one of the major histopathological types of non‐small cell lung cancer (NSCLC), including solid, acinar, lepidic, papillary and micropapillary subtypes. Increasing evidence has shown that micropapillary LUAD is positively associated with a higher percentage of driver gene mutations, a higher incidence of metastasis and a poorer prognosis, while lepidic LUAD has a relatively better prognosis. However, the novel genetic change and its underlying mechanism in the progression of micropapillary LUAD have not been exactly determined.

Methods

A total of 181 patients with LUAD who underwent surgery at the First Affiliated Hospital of Huzhou University from January 2020 to December 2022 were enrolled. Three predominant lepidic and three predominant micropapillary LUAD tissue samples were carried out using whole‐exome sequencing. Comprehensive analysis of genomic variations and the difference between lepidic and micropapillary LUAD was performed. In addition, the TMEM229A Q200del mutation was verified using our cohort and TCGA‐LUAD datasets. The correlations between the TMEM229A Q200del mutation and the clinicopathological characteristics of patients with LUAD were further analyzed. The functions and mechanisms of TMEM229A Q200del on NSCLC cell proliferation and migration were also determined.

Results

The frequency of genomic changes in patients with micropapillary LUAD was higher than that in patients with lepidic LUAD. Mutations in EGFR, ATXN2, C14orf180, MUC12, NOTCH1, and PKD1L2 were concomitantly detected in three predominant micropapillary and three predominant lepidic LUAD cases. The TMEM229A Q200del mutation was only mutated in lepidic LUAD. Additionally, the TMEM229A Q200del mutation had occurred in 16 (8.8%) patients, and not found TMEM229A R76H and M346T mutations in our cohort, while TMEM229A mutations (R76H, M346T, and Q200del) occurred only in 1.0% of the TCGA‐LUAD cohort. Further correlation analysis between the TMEM229A Q200del mutation and clinicopathological characteristics suggested that a lower frequency of the Q200del mutation was significantly associated with positive lymph node metastasis, advanced TNM stage, positive cancer thrombus, and pathological features. Finally, overexpression of TMEM229A Q200del suppressed NSCLC cell proliferation and migration in vitro. Mechanistically, overexpression of TMEM229A and TMEM229A Q200del both reduced the expression level of phosphorylated (p)‐ERK and p‐AKT (Ser473), and the reduced protein level of p‐ERK in the TMEM229A Q200del group was more pronounced compared to the TMEM229A group.

Conclusion

Our results demonstrated that the TMEM229A Q200del mutant may play a protective role in the progression of LUAD via inactivating ERK pathway, providing a potential therapeutic target in LUAD.
Development of specialized devices for microbial experimental evolution
Authors: Shibai Atsushi , Furusawa Chikara
Published: August 2024

Experimental evolution of microbial cells provides valuable information on evolutionary dynamics, such as mutations that contribute to fitness gain under given selection pressures. Although experimental evolution is a promising tool in evolutionary biology and bioengineering, long‐term culture experiments under multiple environmental conditions often impose an excessive workload on researchers. Therefore, the development of automated systems significantly contributes to the advancement of experimental evolutionary research. This review presents several specialized devices designed for experimental evolution studies, such as an automated system for high‐throughput culture experiments, a culture device that generate a temperature gradient, and an automated ultraviolet (UV) irradiation culture device. The ongoing development of such specialized devices is poised to continually expand new frontiers in experimental evolution research.
Complement anaphylatoxins: Potential therapeutic target for diabetic kidney disease
Authors: Ma Jingyuan , Yiu Wai Han , Tang Sydney C. W.
Published: August 2024

Diabetic kidney disease (DKD) is the most common cause of kidney failure, characterized by chronic inflammation and fibrosis. The complement system is increasingly implicated in the development and progression of diabetic nephropathy. The important complement anaphylatoxins C3a and C5a are key mediators of the innate immune system, which regulates cellular inflammation, oxidative stress, mitochondrial homeostasis and tissue fibrosis. This review summarizes the involvement of anaphylatoxins in the pathogenesis of diabetic kidney disease, highlights their important roles in the pathophysiologic changes of glomerulopathy, tubulointerstitial damage and immune cell infiltration, and discusses the modulatory effects of new anti‐diabetic drugs acting on the complement system. Based on available clinical data and findings from the preclinical studies of complement blockade, anaphylatoxin‐targeted therapeutics may become a promising approach for patients with DKD in the future.
Effect of semaglutide on primary prevention of diabetic kidney disease in people with type 2 diabetes: A post hoc analysis of the SUSTAIN 6 randomized controlled trial
Authors: Wang Jingyu , Yang Juhong , Jiang Wenhui , Liu Wenyan , Shen Zewei , Gao Zhongai , Chang Baocheng
Published: August 2024

Aim

Efficient primary prevention of diabetic kidney disease (DKD) is currently lacking. The identification of people at high DKD risk and timely intervention are key to preventing DKD. Therefore, a model to classify people according to their risk for developing DKD was developed previously and used in the current analysis to assess the effect of semaglutide versus placebo on primary DKD prevention.

Methods

Participants with type 2 diabetes from the randomized, double‐blind, placebo‐controlled SUSTAIN 6 trial without DKD at baseline who received 0.5/1.0 mg semaglutide or placebo were grouped by baseline DKD risk, calculated using a validated model. The main post hoc outcome was the effect of semaglutide versus placebo on the proportion of participants who developed DKD [urinary albumin/creatinine ratio (UACR) ≥30 mg/g and/or estimated glomerular filtration rate <60 mL/min/1.73 m2]. Additional post hoc outcomes included changes in DKD risk score, UACR and estimated glomerular filtration rate over time.

Results

Of the total 1139 participants included in the analysis, 28.7% developed DKD; more participants with a high DKD risk (952/1139) developed DKD. Semaglutide significantly reduced the risk of developing DKD in both the total [odds ratio 0.56 (95% confidence interval: 0.42; 0.74; p < 0.0001)], and high DKD risk population [odds ratio 0.51 (95% confidence interval: 0.38; 0.69; p < 0.0001)] and significantly delayed DKD development versus placebo. The beneficial effects of semaglutide were largely driven by UACR changes. The number needed to treat for semaglutide in the high DKD risk population was 7.

Conclusions

This post hoc study indicates that semaglutide may have beneficial effects on primary DKD prevention in people with T2D.
Common atrial reservoir strain during the interstage period is a predictor of poor outcomes prior to Fontan completion in hypoplastic left heart syndrome
Authors: Wang Alan P. , Polsen Cassandra , Penk Jamie , Husain Nazia , Hauck Amanda , Jone Pei‐Ni
Published: August 2024

Background

The atrium augments ventricular function, but the significance of atrial function in hypoplastic left heart syndrome (HLHS) has not been well evaluated.

Objective

We investigated the association of atrial reservoir strain (common atrial strain [CAS]) to death or need for transplantation in patients with HLHS.

Methods

In this retrospective single‐center study, echocardiograms from three timepoints (pre‐stage 1 palliation [S1P], 4–8 weeks post‐S1P, and pre‐Glenn) were analyzed in infants with classic HLHS. Patients were separated based on transplant‐free survival to Fontan (survivors) versus death or heart transplant prior to Fontan (composite outcome). Echocardiographic parameters evaluated included CAS, right ventricle (RV) global longitudinal strain (RVGLS), RV fractional area change (FAC), and tricuspid annular plane systolic excursion (TAPSE). An equal variance t‐test, regression, and receiver operating characteristic (ROC) analyses were performed.

Results

A total of 45 HLHS patients (25 survivors, 20 patients meeting endpoint) were included in this study. There were no significant differences in any of the functional parameters during the pre‐stage 1 or post‐stage 1 timepoints. Pre‐Glenn CAS and RVGLS were significantly worse in those meeting composite endpoint compared to survivors. CAS was significantly correlated to RVGLS during the pre‐S1P and pre‐Glenn timepoints. A pre‐Glenn CAS < 19.5 had an area under the curve of  .78 and a 75% sensitivity and 83% specificity for death or need for transplantation.

Conclusion

Pre‐Glenn CAS is significantly lower in patients with mortality or need for the transplantation prior to Fontan completion and may carry prognostic significance in patients with HLHS.