bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of planting dates on the growth and yield of five varieties of sugarbeet (Beta vulgaris L.)
Authors:   Bangladesh Agricultural University, Das D. R.
Published: March 2023

An experiment was carried out at the Horticulture Farm, Bangladesh Agricultural University, Mymensingh, from November 2014 to April 2015, to study the effect of planting dates on the growth and yield of five varieties of sugarbeet (Beta vulgaris L.). The experiment consisted of two planting dates such as 16 November and 30 November and five varieties, viz., Serenada, Aranka, Belleza, Danicia, and Natura. The experiment was laid out in a Randomized Complete Block Design with three replications. Observations were made on yield and different plant characters, e.g., plant height, number of leaves/plants, root length, fresh weight of root/plant, root yield/plot, root yield/ha, fresh weight of leaves/plant, leaf yield/plot, leaf yield/ha, dry weight of root/plant, dry weight of leaves/plant, root diameter and total soluble solids (TSS). The results showed that planting dates significantly affected yield and all the plant characters of sugarbeet under study. The higher root yield (27.69, 32.10 and 32.71 t ha-1) and the higher leaf yield (13.61, 25.728 and 26.93 t ha-1) were recorded from 16 November planting at 90, 120 and 150 DAP, respectively. The root yield and leaf yield decreased gradually after planting on 16 November. The effect of varieties significantly influenced the growth and yield of sugarbeet. The higher root yield (25.14, 39.68 and 41.96 t ha-1) and leaf yield (17.56, 30.12 and 31.64 t ha-1) were found in the variety Serenada at 90, 120 and 150 DAP, respectively. The lower root yield (17.20, 21.24 and 24.81 t ha-1) and leaf yield (4.74, 17.83 and 18.73 t ha-1) were obtained from the variety Danicia at 90, 120, and 150 DAP, respectively. The combined effect of planting dates and variety significantly affected growth and yield. Serenada variety gave the maximum root yield (31.63, 41.43 and 45.14 t ha-1) and leaf yield (21.6, 30.20, and 31.94 t ha-1) with 16 November planting at 90, 120, 150 DAP, respectively. The minimum root yield (10.24, 20.36 and 24.08 t ha-1) and leaf yield (2.4, 17.41 and 18.07 t ha-1) with 30 November planting at 90, 120 and 150 DAP, respectively were obtained from the variety Danicia. The results indicated that all the varieties gave a higher yield on 16 November planting than the planting on 30 November and the Serenada variety gave the highest yield among the varieties.
Faltas disciplinarias en el servicio civil peruano.Compendio de criterios jurisprudenciales
Authors: Pichón De La Cruz Junior
Published: March 2023

¿Cómo se sancionan los casos de negligencia, acoso, tráfico de influencias y otras faltas en las entidades del Estado? En Faltas disciplinarias en el servicio civil peruano. Compendio de criterios jurisprudenciales, se desarrolla cada una de las faltas disciplinarias previstas en la Ley 30057 y su reglamento general, así como los tipos infractores y la casuística. Con esta información se podrán aplicar adecuadamente el régimen disciplinario y sus sanciones.
Sabor peruano. Travesías musicales
Authors: Pacora Cabrera Luis Alexander , Blanc Rojas Enrique
Published: March 2023

La revisión que hace esta obra de un siglo de música es notable e inédita. Emprendida en complicidad con un grupo de periodistas, investigadores y músicos, nos lleva de viaje por las raíces y los frutos de la prolíﬁca música peruana. Veintiún crónicas y ensayos nos introducen en este universo sonoro que, al igual que la gastronomía de Perú, posee una exquisita y fascinante diversidad que merece ser escuchada fuera de las fronteras de esta milenaria y maravillosa tierra.
María Jesús Alvarado. Retrato de una intelectual y activista peruana
Authors: Ysla Heredia Leonardo
Published: March 2023

A través de esta publicación, descubriremos a esta intelectual y activista que dedicó su vida a la educación y a la lucha social, desde sus inicios en su querida Chincha, la formación de la primera institución femenina peruana Evolución Femenina, sus grandes luchas por el indígena y por la niñez hasta su exilio y sus últimos días prácticamente en el olvido. Esta biografía está dirigida a un público juvenil y a aquellos lectores que quieran conocer más sobre una de las mujeres con mayores aportes a la cultura de nuestro país.
Reciclajes arquitectónicos. Arquitectura limeña doméstica transformada
Authors: Balerdi Arrarte Jorge , Giacchetti Lobatón Eugenio
Published: March 2023

A lo largo de la historia, algunos edificios se han mantenido, mientras que otros desaparecieron, ya sea por efectos de la intemperie, fallas estructurales, desastres naturales, actividades humanas o, simplemente, por antigüedad. Estos edificios desaparecidos fueron considerados obsoletos por tales razones, y reemplazados por otros nuevos. Pero algunos permanecieron. La mayoría de los que pudieron sobrevivir lo hicieron gracias a sus méritos arquitectónicos. Así, quienes los vivieron en momentos críticos tomaron la decisión de que tenía más sentido conservarlos que renunciar por completo a ellos. Motivados por este propósito, Balerdi y Giacchetti presentan Reciclajes arquitectónicos. Arquitectura limeña doméstica transformada, un libro que analiza la evolución de las ideas a través del ejercicio académico de la Transformación, practicado en el curso Taller III - Arquitectura y Entorno, de la Facultad de Arquitectura de la UPC.
El dios del rayo. De hirka Llamoq a san Pedro de Huancarpata
Authors: Guerrero Támara Vidal
Published: March 2023

Este libro es un aporte a los estudios sobre el poblador andino, cómo vive y construye su realidad. Vidal Guerrero analiza el sincretismo que se produjo entre el dios del rayo, representado por el hirka Llamoq, y la imagen de san Pedro de Huancarpata en la provincia de Huari (Áncash, Perú).
The Correlation of Coping Strategies and Burnout Syndrome among Health Workers in Regional Hospital Dr. Soebandi Jember
Authors: Sari Devi Octavia Kartika , Marchianti Ancah C N , Kusumastuti Inke
Published: March 2023

The Covid-19 pandemic significantly impacts the mental health of health workers, including leading to the occurrence of burnout syndrome. Health workers in Dr. Soebandi Regional Hospital, as a regional referral hospital for Covid-19, were potentially exposed to the risk of experiencing burnout syndrome. Effective coping strategies might alleviate burnout syndrome symptoms. Therefore, this study was conducted to analyze the correlation of coping strategies and burnout syndrome level among health workers at Dr. Soebandi Regional Hospital. This cross-sectional study conducted from November to December 2021 included 88 physicians and nurses of Dr. Soebandi Regional Hospital. Data were collected using the Brief Cope Inventory and the Maslach Burnout Inventory Questionnaires. The SPSS spearman rho analysis showed a weak significant positive correlation of maladaptive coping strategies and burnout syndrome level (r=0.263; p=0.0013). The self-blame coping strategy had a weak significant positive correlation with burnout syndrome level (r=0.267; p=0.0012). We recommend to develop programs to protect health workers from becoming secondary victims of various adverse events and counseling provision to doctors and nurses regarding appropriate coping strategies for stress management at work.
Keywords: Burnout Syndrome; coping strategy; RSD Dr. Soebandi; Mental Health.
The Duality of High and Low Culture in D. H. Lawrence’s Lady Chatterley’s Lover
Authors: BULUT SARIKAYA Dilek
Published: March 2023

Lawrence, in Lady Chatterley’s Lover (1928), reflects the post-war modern British society which condemns its individuals into a psychological trauma of ongoing conflicts between different classes and cultures. Advocating the exigency of a classless society, Lawrence shatters the hegemonic ideology of the highbrow culture which disdains working class culture as vulgar, coarse and commonplace. Reacting against the cultural displacement of working classes who are considered as masses, Lawrence indulges in revealing the authenticity and earnestness of the working class culture. Lawrence’s depiction of an uncorrupt ethical standing of the working class culture is the negation of the concept of culture, associated with high class manners and ways of life. The prevailing concern of this study, therefore, will be to analyze Lawrence’s Lady Chatterley’s Lover from the perspective of cultural studies to unravel the clash of high and low cultures in relation to the hierarchical class structure of the post-war England.
Acute Kidney Injury with Hyperlactatemia: Clues to a Hidden Problem
Authors: Almeida Sara Isabel , Oliveira Sara , Matos Eugénia , Abecasis Francisco
Published: March 2023

N/a.
Mating still disrupted: Future elevated CO2 concentrations are likely to not interfere with Lobesia botrana and Eupoecilia ambiguella mating disruption in vineyards in the near future
Authors: Becker Christine , Rummel Anna , Gallinger Jannicke , Gross Jürgen , Reineke Annette
Published: March 2023

The successful, area-wide application of the mating disruption (MD) technique, an insect sex pheromone-based biotechnological pest control method, against the European grapevine moth Lobesia botrana and the European grape berry moth Eupoecilia ambiguella, has led to drastic reductions in insecticide application in vineyards. However, since insect pheromone perception and emission can be affected by abiotic conditions, the future success of MD may be affected by climate change. At the same time, politics and society are calling for drastic and sustainable reductions in pesticide application, making highly specific, efficient, and environmentally friendly pest control techniques like MD more important than ever. To anticipate whether climate change factors will interfere with the MD of L. botrana and E. ambiguella in vineyards, we conducted field experiments in the Geisenheim VineyardFACE (Free-Air Carbon dioxide Enrichment) facility. The insects were raised at ambient or elevated temperatures in the lab and male moths were released in cages installed in the VineyardFACE facility. Trap recapture rates obtained by pheromone lures or female moths under elevated or ambient CO2 in areas with and without MD were evaluated. Our results did not indicate a reduced efficacy ofL. botrana or E. ambiguella MD at elevated CO2 concentrations, irrespective of the temperature the moths were raised under. From a practical point of view—and especially from an ecological one—our results are good news. They indicate that MD will not be negatively affected by future elevated CO2 concentrations.
Circular RNAs: implications of signaling pathways and bioinformatics in human cancer
Authors: Hu Fan , Peng Yin , Fan Xinmin , Zhang Xiaojing , Jin Zhe , Jin Zhe
Published: March 2023

Circular RNAs (circRNAs) form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic cells. These RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes, such as transcriptional regulation and splicing. They serve predominantly as microRNA sponges, RNA-binding proteins, and templates for translation. More importantly, circRNAs are involved in cancer progression, and may serve as promising biomarkers for tumor diagnosis and therapy. Although traditional experimental methods are usually time-consuming and laborious, substantial progress has been made in exploring potential circRNA-disease associations by using computational models, summarized signaling pathway data, and other databases. Here, we review the biological characteristics and functions of circRNAs, including their roles in cancer. Specifically, we focus on the signaling pathways associated with carcinogenesis, and the status of circRNA-associated bioinformatics databases. Finally, we explore the potential roles of circRNAs as prognostic biomarkers in cancer.
The Effect of Coffee Husk Waste Addition with Alkalisation Treatment on the Mechanical Properties of Polypropylene Composites
Authors: Melyna Ella , Afridana Atika Pratiwi
Published: March 2023

ABSTRACT. Indonesia is the fourth largest coffee producing country in the world with 762.38 thousand tonnes production in 2020. The coffee bean waste in the form of coffee skins is around 50-60% of the harvest. Coffee skin waste is a type of natural material that has not been widely used. Processing coffee skin waste as a filler in thermoplastic polymers can be a solution to environmental problems. This study using the polypropylene matrix. This study was conducted to determine the effect of adding coffee husk by alkalizing treatment on polypropylene composites on tensile strength, impact strength and flexural strength. The composition of coffee husk used is 20, 30, 40% wt. The coffee husk was first alkalized with 5%, 8%, and 11% KOH to remove lignin. Composite manufactured using manual forming machines. The results of this study indicate that the addition of coffee husk reduces the value of the tensile strength and flexural strength of the polypropylene composite. The addition of 20% wt coffee husk with 5% KOH alkalisastion on the polypropylene composite gave the highest tensile strength value of 5.65 MPa and the highest flexural strength of 28.72 MPa. Alkalisastion treatment with KOH on coffee husk reduces the value of tensile strength and flexural strength in polypropylene composites. The treatment without 0% KOH alkalisastion on coffee husk gave the highest tensile strength value of 13.30 MPa and alkalizing treatment with 5% KOH on coffee husk gave the highest flexural strength value of 28.72 MPa with the addition of 20% wt coffee husk. Alkalisastion treatment with KOH on coffee husk increased the impact strength value on polypropylene composites. Alkalisastion treatment with 11% KOH on coffee husk gave the highest impact strength value of 4.62 kJ/m2 with the addition of 20% wt coffee husk.

Keywords: composite, polypropylene, coffee husk, alkalisation

 
Adjacent Segment Impingement: A New Type of Adjacent Segment Disease?
Authors: Skaggs Kira F. , Stephan Stephen , Perry Tiffany G. , Skaggs David L.
Published: March 2023

Case:

We present 3 cases in which spinal rods extending beyond the intended level of fusion caused injury to adjacent structures, which we term “adjacent segment impingement.” All cases presented as back pain with no neurological symptoms, with a minimum 6 years of follow-up from the initial procedure. Treatment consisted of extending the fusion to include the affected adjacent segment.

Conclusion:

We recommend surgeons check to ensure spinal rods are not abutting adjacent level structures at the time of the initial implant while considering that adjacent levels may move closer to the rod during spine extension or twisting.
A case report and literature review of a death caused by Aeromonas daca complicated with septic shock
Authors: Zhao Qiquan
Published: March 2023

Background: For decades, Aeromonas daca has often been mistaken for Aeromonas hydrophila by phenotypic identification systems and shows obvious characteristics of virulence. To our knowledge, a total of two English-language studies with relatively complete data were retrieved.Case presentation: The patient, a 26-year-old male with no underlying disease, was admitted to our hospital for 3 days because of cough, expectoration and shortness of breath. According to blood and lavage fluid cultures and next-generation sequencing (NGS), the patient was diagnosed with an A. daca infection. He soon deteriorated to a critical condition complicated with septic shock and died after active rescue treatment. Conclusions: A. daca infection is lethal, and an accurate taxonomy can improve our understanding of the epidemiological distribution and virulence potential of this human pathogen. Third-generation cephalosporins and carbapenems should be used cautiously in the treatment of severe A. daca infection, and the best regimen is cefepime or fluoroquinolones.
TangNingTongluo tablet, a traditional Chinese medicine for the treatment of nonproliferative diabetic retinopathy: Study protocol for a randomized controlled trial
Authors: pei li , Xing Yao , Wu Meichu , ran chuanlian , dong yulu , Zhang Fuwen , Duan Junguo , pu siyuan
Published: March 2023

Background

Diabetic retinopathy (DR) is a common microvascular complication of diabetes. At present, there are few safe and effective drugs for DR. We report the protocol for a pragmatic randomized controlled trial of the use of a traditional Chinese herbal medicine to treat patients with DR.

Methods

This will be a multicentre randomized controlled trial. A total of 240 participants diagnosed with nonproliferative diabetic retinopathy (NPDR) recruited from 11 institutions will be randomly allocated at a 1:1 ratio to two groups. The study is divided into a basic treatment period and an extended treatment period. All participants will receive a 24-week treatment and then be followed up for another 24 weeks. After the 24-week basic treatment period, the investigator will decide whether to enter the extended treatment period according to the patient's condition and willingness to continue using the drug until 48 weeks. The primary outcome is the mean change in best-corrected visual acuity and DR progression rate at weeks 24 and 48 compared to baseline.

Discussion

This study will provide evidence regarding the effectiveness and safety of TangNingTongluo tablets in treating patients with NPDR.

Trial registration

Chinese Clinical Trial Registry (http://www.chictr.org.cn), ChiCTR2100049803, registered on 9 August 2021.
The interaction effect of renewables, economic and industrial development on CO2 emissions in top solar energy producers
Authors: Namahoro Jean Pierre , Wu Qiaosheng
Published: March 2023

This study examined the interaction effect of renewable energy use, industrial and economic growth on CO2 emissions, and the individual effect of these variables on CO2 across 44 countries that highly produce and consume solar energy from 1996 to 2018. Cross-sectionally augmented distributed lags (CS-DL), cross-sectionally augmented autoregressive distributed lags (CS-ARDL) and other methods were employed. Findings reveal that solar energy use reduces CO2, while economic and industrial development positively affects CO2. The interaction effect from both renewable energy and economic growth, renewable energy and industrial development, and industrial and economic development negatively affects CO2 in the long term. Total renewable energy use, solar energy use, and industrial development positively affect economic growth. The impact of renewable energy and solar energy is significant in the long term. In the ten-year forecast, solar energy use and industrial development will have the least contribution to CO2, while total renewable energy consumption and solar energy use will have the least share of economic growth. Causality results strengthen the impact of renewable energy, solar energy, and economic growth on CO2, by showing the direct effect on CO2, while industrial development has a neutral effect on CO2. Solar energy and industrial development have a direct effect on economic growth while economic growth causes renewable energy consumption. The interacting feedback causal effect was noted between the interaction of renewable energy and economic growth and CO2. Based on the results, we suggested the policy implication to strengthen the effect of renewables, industrial and economic growth, and their interaction to reduce CO2 emissions.
A Double Burden of Malnutrition Among Women in the Reproductive Age (15-49 years) in Sierra Leone: A Secondary Data Analysis of the Demographic Health Survey of 2019 (SLDH-2019)
Authors: Ikoona Eric Nzirakaindi , Toure Mame Awa , Njenga Amon , Namulemo Lucy , Kaluya Ronald , Kamara Kassim , Oyat Freddy Wathum Drinkwater , Aloyo Judith , Matovu John Bosco , Kitara David Lagoro
Published: March 2023

Background: A double burden of malnutrition is rising globally but particularly in sub-Saharan Africa. Recently in Sierra Leone, the incidence of overweight, obesity, and overnutrition among women have sharply increased. This study aimed to determine the prevalence of different malnutrition categories (underweight, overweight, obesity, and overnutrition) and associated factors among women of reproductive age in Sierra Leone using Demographic Health Survey of 2019.
Methods: We conducted data analysis of 7,514 women aged 15 to 49 years. Data was collected using validated questionnaires. Participants were selected using a multistage stratified sampling approach. A multivariable regression analysis was used to determine factors associated with different malnutrition categories.
Results: The prevalence of underweight was, 6.7%(95%CI:4.5%-8.9%); overweight, 19.7%(95%CI:17.7%-21.7%); obesity, 7.4% (95% CI:5.2%-9.6%); and overnutrition, 27.1%(95%CI:25.2%-29.0%). Underweight was more likely in 25-34 years (AOR=1.670, 95%CI:1.254-2.224;p<0.001) than 15-24 years; unlikely among single women (AOR=0.594,95%CI:0.467-0.755;p<0.001) than married. Unlikely in the north (AOR=0.734,95%CI:0.559-0.963;p=0.026) compared to east, and unlikely among those who did not listen to radios (AOR=0.673;95%CI:0.549-0.826;p<0.001) compared to those who did.
Overweight was unlikely among 25-34 years (AOR=0.609,95%CI:0.514-0.722;p<0.001) and 35-49 years (AOR=0.480,95%CI:0.403-0.571;p<0.001) than 15-24 years; likely among single women (AOR=1.470,95%CI:1.249-1.730;p<0.001) compared to married; unlikely among working-class (AOR=0.840,95%CI:0.720-0.980;p=0.026) compared to not working-class; most likely in the north (AOR=1.325,95%CI:1.096-1.602;p=0.004), and unlikely in the south (AOR=0.755,95%CI:0.631-0.903;p=0.002) compared to east; unlikely among middle-wealth-index (AOR=0.656,95%CI:0.535-0.804;p<0.001), richer-wealth-index (AOR=0.400,95%CI:0.309-0.517;p<0.001), and richest-wealth-index (AOR=0.317,95%CI:0.234-0.431;p<0.001) compared to poorest-wealth-index respectively, and likely among women who did not listen to radios (AOR=1.149; 95%CI:1.002-1.317;p=0.047) compared to those who did. Determinants of obesity and overnutrition were the same with overweight, except they were unlikely in female-headed-households (AOR=0.717,95%CI:0.578-0.889;p<0.001).
Conclusion: The prevalence of different types of malnutrition among women 15-49 years in Sierra Leone were high; affirming a double burden of malnutrition. It was likely to be underweight among 25-34 years. The predictors of overweight, obesity, and overnutrition were single women, from the north and not listening to radios. There is an urgent need for policies on healthy lifestyles and the dangers of malnutrition.
Effectiveness of Mindfulness-Based Cognitive Therapy in reducing psychological distress and improving sleep in patients with Inflammatory Bowel Disease: study protocol for a multicentre randomised controlled trial (MindIBD)
Authors: Avest Milou M ter , Velthoven Annelieke S M van , Speckens Anne E M , Dijkstra Gerard , Dresler Martin , Horjus Carmen S , Römkens Tessa E H , Witteman Ellen M , Dop Willemijn A , Bredero Quirine M , Nissen Loes H C , Huijbers Marloes J
Published: March 2023

Background

Many patients with Inflammatory Bowel Diseases (IBD) suffer from psychological distress, fatigue and sleep disturbances, which are associated with reduced quality of life (QoL) and increased societal costs. Only limited psychosocial treatment options are available. As Mindfulness Based Cognitive Therapy (MBCT) has demonstrated to improve psychological distress, QoL and sleep in other populations, MBCT might also be effective in patients with IBD.

Methods

The MindIBD study is a prospective, multicentre, randomised controlled trial comparing MBCT plus Treatment As Usual (TAU) versus TAU alone in a targeted number of 136 IBD patients in remission, aged 16 years and older with at least mild psychological distress (Hospital Anxiety and Depression Scale (HADS) total score ≥ 11). Primary outcome is reduction of psychological distress post-intervention, measured by the HADS. In addition, the effect of MBCT on sleep quality (including actigraphy and electroencephalography recordings), fatigue, disease activity, perceived disease control, QoL and positive mental health will be examined. Assessments will be conducted at baseline and at 3, 6, 9 and 12 months follow-up. Cost-effectiveness will be determined and a process evaluation will be conducted.

Discussion

This study will provide valuable insight into the clinical effect of MBCT on psychological distress, sleep quality, fatigue and QoL in IBD patients and into the cost-effectiveness. If effective, MBCT can be a valuable addition to the available psychosocial interventions for patients with IBD. Moreover, findings from this study may also be applicable in patients with other chronic conditions.
Trial registration: ClinicalTrials.gov: NCT04646785, registered on 30/11/2020.
Initial multiple sclerosis presentation as optic neuritis following COVID-19 vaccination: A case report
Authors: Hashim Ahmed Shamil , Al-hassani Ahmed , Al-zaydi Ahmed , Ali Ethar Mushreq
Published: March 2023

Background

The COVID-19 pandemic has been largely controlled upon the extensive vaccination campaigns done by many countries all over the world, with great efficacy and few adverse effects reported. However, since the beginning of the vaccination campaigns, few autoimmune and neurological manifestations were reported.

Case presentation

A previously healthy 23 years old female presented with acute unilateral optic neuritis in the right eye that started one week after receiving the second dose of COVID-19 vaccine. The patient had blurred vision which was partial then progressed over two days to involve the whole visual field along with mild pain upon ocular movement with no doubling of vision. The patient reports no prior neurological manifestations before the onset of this condition. Clinical and radiological features proved the diagnosis with Multiple Sclerosis (MS) later. The patient was treated with intra-venous Methylprednisolone and recovered well after few days of getting the treatment and was scheduled for follow-up to plan her further management.

Conclusion

This case may provide an association between COVID-19 vaccination and the development or triggering of MS. However, more data needs to be collected to look more in this regard.
Primitive to conventional geometry projection for efficient phonon transport calculations
Authors: Lindsay Lucas , Li Xun , Thebaud Simon
Published: March 2023

The primitive Wigner-Seitz cell and corresponding first Brillouin zone (FBZ) are typically used in calculations of lattice vibrational and transport properties as they contain the smallest number of degrees of freedom and thus have the cheapest computational cost. However, in complex materials, the FBZ can take on irregular shapes where lattice symmetries are not apparent. Thus, conventional cells (with more atoms and regular shapes) are often used to describe materials, though dynamical and transport calculations are more expensive. Here we discuss an efficient anharmonic lattice dynamic method that maps conventional cell dynamics to primitive cell dynamics based on translational symmetries. This leads to phase interference conditions that act like conserved quantum numbers and a conservation rule for phonon scattering that is hidden in conventional dynamics which significantly reduces computational cost. We demonstrate this method for phonon transport in a variety of materials with inputs from first-principles calculations and attribute its efficiency to reduced scattering phase space and fewer summations in scattering matrix element calculations.
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth
Authors: Mao Huajie , Wang Runzhi , Shao Fengling , Zhao Ming , Tian Dayu , Xia Hua , Zhao Ya
Published: March 2023

3-Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme for ketone body synthesis, and most current studies focus on mitochondrial maturation and metabolic reprogramming. The role of HMGCS2 was evaluated in a pan-cancer multi-database using R language, and HMGCS2 was lowly expressed or not differentially expressed in all tumor tissues compared with normal tissues. Correlation analysis of clinical case characteristics, genomic heterogeneity, tumor stemness, and overall survival revealed that HMGCS2 is closely related to clear cell renal cell carcinoma (KIRC). Single-cell sequencing data from normal human kidneys revealed that HMGCS2 is specifically expressed in proximal tubular cells of normal adults. In addition, HMGCS2 is associated with tumor immune infiltration and microenvironment, and KIRC patients with low expression of HMGCS2 have worse prognosis. Finally, the results of cell counting kit 8 assays, colony formation assays, flow cytometry, and Western blot analysis suggested that upregulation of HMGCS2 increased the expression of key tumor suppressor proteins, inhibited the proliferation of clear cell renal cell carcinoma cells and promoted cell apoptosis. In conclusion, HMGCS2 is abnormally expressed in pan-cancer, may play an important role in anti-tumor immunity, and is expected to be a potential tumor prognostic marker, especially in clear cell renal cell carcinoma.
Experimental and DFT+U investigations of the Cu 1-x Cd x O nanoparticles synthesized for photocatalytic degradation of organic pollutants: Environmental Application
Authors: Singh Gurdev preet , Singh Jasvir , Singh K. J.
Published: March 2023

The present investigation focuses on the impact of Cd-doping concentration on the structural, optical and photocatalytic degradation properties of the CuO nanostructures. Cd-doped (0, 1 and 3 mol %) CuO nanostructures were synthesized using ball milling cum solid-state reaction method. The physical properties of nanostructures were investigated using Raman, TEM, ultraviolet–visible, photoluminescence spectroscopy, X-ray diffraction, and dynamic light scattering techniques. X-ray diffraction and Raman spectroscopy detect the presence of a monoclinic CuO phase only, which confirms the successful doping of Cd in the CuO matrix. A decrease in particle size with doping has been disclosed by XRD, dynamic light scattering and TEM studies. XRD and PL studies reveal the enhancement in structural defects with doping concentration. Further, the DFT + U approach was used for crystal structure, the density of states and band structure evaluation. The sunlight-driven photocatalytic degradation activity of the samples was tested against organic pollutants (methylene orange (MO) and methylene blue (MB) dyes). The degradation efficiency of the CuO nanoparticles was found to the enhanced with Cd-doping concentration. 3 mol% doped Cd-CuO, shows the best degradation efficiency and successfully degrades 59% and 75% of MO and MB dyes in 240 min under sunlight irradiation. Our samples exhibit a pseudo-first-order kinetic model and the rate constant is found to increase with Cd-doping. Thus, Cd-doped CuO nanostructures possess good candidature for environmental applications.
A Link between The Kuroshio Extension, Marine Heatwaves, and Marine Ecosystems in the Gulf of Alaska
Authors: Silva E. Nishchitha , Anderson Bruce
Published: March 2023

Marine Heatwave (MHW) events in the Northeast Pacific Ocean from 2014-2016 and 2019-present have had significant impacts on ocean life and livelihoods in the region. Numerous studies have linked these MHWs to known modes of climate variabilities. Using multiple datasets, here we show that the observed evolution of the 2012-2015 marine heatwave in the Gulf of Alaska (GOA) best correlates with the evolution of historical sea surface temperatures (SSTs) in response to large-scale variations in the Kuroshio Extension (KE) region. Further, we report the physical and biogeochemical changes during this MHW and their relation to these same KE variations. Based on these results we propose a link between large-scale KE variations and MHWs in the GOA. A link that further extends to the marine biogeochemistry and productivity in the region via KE-influenced modifications to mixed layer thickness. Our findings offer baseline guidance for understanding the biological implications of KE variations on the GOA and can aid in the formulation of climate-related fisheries policies on a local, regional, and global scale, both under current conditions and in response to future anthropogenic-induced changes in the KE.
Investigations on Process Parameters of Cluster Magnetorheological Polishing in a planet motion model
Authors: chen song , Cai Tianwu
Published: March 2023

A planetary-type cluster magnetorheological polishing device with a rotating magnetic field was proposed to solve the problems of abrasive accumulation and low polishing efficiency caused by the untimely restoration of the conventional magnetic chain. Considering the microstructural deformation and squeeze-strengthening effect of magnetorheological polishing fluid, a material removal rate model was established based on the principle of fluid dynamic pressure and verified by experiments. The relationships between material removal rate or roughness and processing parameters were confirmed by multiple linear regression analyses, respectively. And the processing parameters optimization was made by linear weighting method under the premise of establishing the evaluation system. The results show that the eccentricity and angular velocity ratio are proportional and inversely proportional to MRR, respectively. When the polishing fluid is squeezed, the material removal rate can be significantly increased from 7nm/min to 21nm/min, but the roughness will be reversed at a gap of less than 0.9mm. After the optimization of processing parameters, the workpiece roughness after rough and fine polishing was reduced from 1.079µm and 1.083µm to 0.346µm and 0.184µm, with a reduction of 67.9% and 83.01%.
The impact of neighborhood mental health on the mental health of older adults
Authors: Gong Rengui , Xia Dongping , Hu Zan , Hu Yangming
Published: March 2023

Background：The health problems of aging have attracted immense attention in recent years. Researchers are concentrating on the health of older adults from different perspectives.This report attempts to explore the impact of neighborhood mental health effects on the mental health of older adults from the neighborhood relationship.
Methods：Based on the data received from the China Health and Retirement Tracking Survey (CHARLS) in 2018, people aged 60 and above were selected as the research objects (N=7713). The ordinary least square (OLS) regression model was used to analyze the influence of neighborhood mental health effect on the mental health of older adults. Furthermore, instrumental variables estimation using two-stage least-squares (IV-2SLS), heterogeneity analysis, and robustness test were used to strictly verify the effect of neighborhood mental health on the mental health of older adults. The KHB decomposition was used to examine the mechanism of effect.
Results：Baseline regression showed that the neighborhood mental health effect positively affected the mental health of older adults (B=0.356, CI= [0.315,0.397]). The neighborhood mental health effect estimated by IV-2SLS (B=0.251, CI=[0.096,0.405]) was higher than that of OLS regression, indicating endogeneity. The mediating effect of KHB showed that the total effect (B=0.356, CI=[0.314,0.398]), direct effect (B=0.281, CI=[0.232,0.330]), indirect effect (B=0.075, CI=[0.049,0.101]). and the total effect was 1.266 times of the direct effect, and 21.03% of the total effect came from the intermediary variable.
Conclusions：First, the neighborhood mental health effect had a positive impact on the mental health of older adults, but there are heterogeneity differences based on gender, age, residence, and other aspects. Second, the results of IV-2SLS estimation revealed that without controlling for endogenous problems, the effect of neighborhood mental health effects was underestimated. Third, county-level neighborhood mental health, life satisfaction, three-year self-assessment health change, and physical health were used to replace variables, and physical disability (small sample) and non-disability (large sample) were grouped. The effect of neighborhood mental health on older adults' mental health is stable. Finally, social connection, participation, and interaction are important mediating mechanisms for the effect of neighborhood mental health on the mental health of older adults.
Comparative transcriptomic analysis of Illumina and MGI next generation sequencing platforms using RUNX3- and ZBTB46-instructed embryonic stem cells
Authors: Póliska Szilárd , Fareh Chahra , Lengyel Adél , Göczi Loránd , Tőzsér József , Szatmari Istvan
Published: March 2023

We have previously observed phenotypic and developmental changes upon the ectopic expression of the RUNX3 or the ZBTB46 transcription factors in mouse embryonic stem cell (ESC) derived progenitors. In this study we evaluated the gene expression profiles of the RUNX3- and the ZBTB46-instructed murine ESCs with RNA-Seq testing two next generation sequencing (NGS) technologies. We compared the DNA nanoball (DNB) based MGI DNBSEQ G400 sequencer with the bridge-PCR based Illumina NextSeq 500 instrument. Moreover, we also compared two types of MGI sequencing reagents (Standard- versus Hot-MPS) with the DNBSEQ G400. Importantly, very similar gene expression profile and greatly overlapping RUNX3 and ZBTB46 regulated gene sets were detected with both platforms. Moreover, almost identical gene expression pattern was obtained with the Hot-MPS reagent compared to the Standard-MPS chemistry. This transcriptomic analysis also facilitated the identification of RUNX3 and ZBTB46 regulated genes. For example, we found that Gzmd, Gdf6 and Ccr7 genes were robustly upregulated upon the forced expression of Runx3, on the other hand, Gpx2, Tdpoz4 and Arg2 were induced upon the ectopic expression of Zbtb46. Together these findings demonstrate that the DNBSEQ G400 system is also suitable for global transcript profiling and target gene selection with lower cost.
A coupled hydro-chemo-mechanical approach to model the degradation and appearance of cracks in cementitious materials subject to carbonation
Authors: Seigneur Nicolas , Socié Adrien , Bary Benoit , Poyet Stéphane , Touzé Gaëtan
Published: March 2023

Coupled Thermal-Hydraulic-Mechanical-Chemical (THMC) approaches are crucial for assessing the durability of cementitious materials. We present a novel approach to overcome past limitations of THMC modelling and validate it based on experimental results of accelerated carbonation tests. Our numerical approach rests on a sequential coupling between Hytec and Cast3M. Hytec computes the evolution of hydraulic and mineralogical fields allowing to compute the micromechanical properties (e.g. Young modulus). The mineral reactions generate tensile stresses and Cast3M computes the associated strain tensors and the damage evolution represented by the opening or sealing of cracks, impacting subsequent reactive transport processes. Our approach manages to reproduce the crack patterns and non-uniform degradation depths observed on microtomographic images of carbonated cement samples, which can only be explained by the coupled dynamics of chemical and mechanical processes. Our approach can be extended to a wide range of cement-concrete pathologies and contexts.
Causal associations of brain structure with bone mineral density: a large-scale genetic correlation study
Authors: Zhao Shu-Shan , Guo Bin , Wang Chao , Zhu Yong , Liu Zhi , Long Haitao , Ruan Zhe , Lin Zhang , Fan Zhi , Li Yusheng
Published: March 2023

This study aimed to investigate the causal associations of brain structure with bone mineral density (BMD). Based on the genome-wide association studies (GWAS) summary statistics of 1325 brain imaging-derived phenotypes (BIDPs) of brain structure from the UK Biobank, and GWAS summary datasets of 5 BMD locations, including total body, femoral neck, lumbar spine, forearm, and heel from GEFOS Consortium, linkage disequilibrium score regression (LDSC) was conducted to determine the genetic correlations and Mendelian randomization (MR) was then performed to explore the causal relationship between the BIDPs and BMD. Several sensitivity analyses were performed to verify the strength and stability of the present MR outcomes. To increase confidence in our findings, we also performed a confirmatory MR between BIDPs and osteoporosis. LDSC revealed that 1.93% of BIDPs, with a false discovery rate (FDR) < 0.01, genetically correlated with BMD. Additionally, we observed that 1.31% of BIDPs exhibited a significant causal relationship with BMD (FDR < 0.01) through MR. Both the LDSC and MR results demonstrated that the BIDPs “Volume of normalized brain”, “Volume of grey matter in Left Inferior Frontal Gyrus, pars opercularis”, “Volume of Estimated Total Intra Cranial” and “Volume-ratio of brain segmentation/estimated total intracranial” had strong associations with BMD. Interestingly, our results showed that more left BIDPs were causally associated with BMD, especially within and around the left frontal region. In conclusion, a part of brain structure causally influences BMD, which may provide important perspectives for the prevention of osteoporosis and offer valuable insights for further research of the brain-bone axis.
Empirical comparison of assembly complexity assessment approaches in manufacturing
Authors: Capponi Matteo , Mastrogiacomo Luca , Franceschini Fiorenzo
Published: March 2023

Investigating assembly complexity is a continuing concern within manufacturing field, as it may impact quality and costs of products. There is a growing body of literature aimed at developing novel and reliable methods to assess assembly complexity. The first aim of this paper is to provide an extensive literature review, identifying the main approaches to this problem. Three main approaches emerged: product-centred approach, information-centred approach and system-centred approach. A second goal is to carry out a comparative analysis of these approaches highlighting their advantages, limitations and providing guidance for process and product designers seeking to control assembly complexity. For each approach, a representative method was chosen, analysed in detail, and applied to three different real products.
Factors influencing HIV Testing among young women aged 15-24 in the 2015-2016 Malawi Demographic and Health Survey
Authors: Koroma Mark Momoh , Chigoneka Kuleza , Kabba John Alimamy , Yu Jing-Rong , Senabye Pauline Kerapetse , Dai Ying-Chun , Wang Lu , Xie Dong-Jie , Wanda Jessicah
Published: March 2023

Purpose
Adolescent girls and young women exhibit two of three global new HIV infections every day, yet they perceived little risk of acquiring it, thus neglecting their status. HIV Testing is fundamental to its prevention and achieving the UNAIDS three 90s.
Methods
We obtained data from the 2015–2016 Malawi Demographic and Health Survey on women to establish the HIV testing factors. We employed SPSS bivariate and multivariate logistic regression to determine HIV testing factors among young women aged 15–24.
Results
Of all 10422 young women, 69.5% have done the test, and most were rural dwellers. Ages 20–24 were more than 2.6 times (AOR = 2.69; 95% CI = 2.11–3.43) more likely to do HIV testing than those aged 15–19. Reading newspapers or magazines less than once a week and listening to the radio at least once a week increased HIV testing by 1.9 and 1.5 times, respectively. A visit to a health facility in the past 12 months influenced HIV testing by 3 (AOR = 3.06; 95% CI = 2.41–3.89) times. Contraceptives and condoms used influenced HIV testing 4.4 (AOR = 4.40; 95% CI = 3.24–5.96) and 2.1 (AOR = 2.17; 95% CI = 1.09–4.30) times. Employed and wealthy young women were 1.6 times more likely to be tested. Husbands’ education positively influenced HIV testing while living in rural areas negatively influenced it.
Conclusions
Our findings highlight potential factors in improving HIV testing and indicate that robust strategies need to be implemented to increase HIV testing among young women in Malawi. Future research should focus on motivating factors that will enhance HIV testing uptake in Malawi young women.
Spatial modelling of both extra zeros and extreme values in ecological counts: an example with sardine eggs in Portugal
Authors: Pereira Soraia , Moreira Guido , Menezes Raquel , Angélico Maria Manuel , Marques Tiago
Published: March 2023

Understanding the spatial distribution of animals, as well as how the distributions are influenced by environmental covariates, is a fundamental requirement for the effective management of animal populations. The sardine is one of the most important fisheries species in Portugal, for its economic, sociologic, anthropologic and cultural values. Here we intend to understand the spatial distribution of the sardine eggs density ($eggs/m^3$). The data structure presents an excess of zeros and extreme values relative to the commonly chosen distributions to fit this data. To deal with this, we propose a geostatistical Gamma - Generalized Pareto hurdle model to jointly model the probability of presence, the positive sardine eggs density, and the corresponding exceedances. We have followed a Bayesian hierarchical approach and the inference was made through Markov Chain Monte Carlo methods. The results show that presence of sardine eggs is associated with depth, salinity and fluorescence; whereas positive density of sardine eggs is mainly associated with depth and fluorescence. The variable that most explains the extreme values is fluorescence.
Loci Associated with Postpartum Depression: A Genome-Wide Association Study
Authors: Tomita Hiroaki , Li Xue , Takahashi Nagahide , Narita Akira , Nakamura Yukako , Sakurai-Yageta Mika , Murakami Keiko , Ishikuro Mami , Obara Taku , Kikuya Masahiro , Ueno Fumihiko , Metoki Hirohito , Ohseto Hisashi , Takahashi Ippei , Nakamura Tomohiro , Warita Noriko , Shoji Tomoka , Yu Zhiqian , Ono Chiaki , Kobayashi Natsuko , Kikuchi Saya , Nagami Fuji , Ogishima Soichi , Sugawara Junichi , Hoshiai Tetsuro , Saito Masatoshi , Fuse Nobuo , Kinoshita Kengo , Yamamoto Masayuki , Yaegashi Nobuo , Ozaki Norio , Tamiya Gen , Kuriyama Shinichi
Published: March 2023

Although postpartum depression (PPD) has been identified as a severe public health problem, its genetic basis has yet to be elucidated. Therefore, we conducted a genome-wide association study (GWAS) to identify the loci significantly associated with PPD. The first and second cohorts (n = 9,260 and n = 8,582 perinatal women enrolled in the Tohoku Medical Megabank Project [TMM]), and the third cohort (n = 997), recruited at Nagoya University, were subjected to genotyping. PPD was defined based on the Edinburgh Postnatal Depression Scale one month after delivery. Logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for the most influential confounders, including the number of deliveries and the number of family members living together. A meta-analysis of GWAS results from the three cohorts indicated the following loci as significantly associated with PPD (P < 5´10–8): rs377546683 at DAB1 (1p32.2), rs11940752 near UGT8 (4q26), rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2 (5q35.1), rs188907279 near ZNF572 (8q24.13), rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2 (9q22.2), rs1435984417 at ZNF618 (9q31.3), rs57705782 near PTPRM (18p11.23), and rs185293917 near PDGFB (22q13.1). Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over-represented in categories including long-term depression, GnRH signaling, Glutamatergic synapse, Oxytocin signaling, and Rap1 signaling. Thus, the current GWAS study identified eight loci significantly associated with PPD, which may enlighten the genetic structure underlying the pathogenesis of PPD.