bluuebunny/crossref_metadata_2025 huggingface dataset:
A Protocol on Antimicrobial effectiveness of adjunctive disinfection techniques during root canal therapy in patients with pulp necrosis and apical periodontitis. A Systematic Review & Meta-analysis
Authors: Sadaf Durre , Ahmad Zubair , Onakpoya Igho -
Published: December 2019

Background The primary objective of root canal therapy is to eliminate bacteria from the root canal system of teeth. However, standard chemo-mechanical disinfection has been found unable to remove bacteria within the root canals. Clinicians tempted to use additional disinfection techniques to achieve adequate level of disinfection. There is no such systematic review that could comprehensively compare the efficiency of all currently used disinfection techniques. This systematic review aims to compare the antimicrobial effectiveness of various adjunctive disinfection techniques with standards chemo-mechanical disinfection technique(needle syringe irrigation) used during root canal therapy in patients with pulp necrosis and apical periodontitis.Methods A well-defined structured clinical question in the form of PICO (Patients/Problem, Intervention, Comparison, Outcome) is designed. The unit of analysis in this review is a tooth. Teeth with apical periodontitis is a problem (P). Interventions (I) are supplemental disinfection techniques that include photodynamic therapy, passive ultrasonic irrigation, and negative pressure techniques. Comparison (C) will be standard chemo-mechanical disinfection technique. Outcome (O) is the effectiveness of antimicrobial activity in the form of detection of bacteria and colony-forming units (CFU). Keywords, MeSH terms, and synonyms will be searched through previous literature, books, and Medline database. We will perform a comprehensive search strategy using electronic databases MEDLINE (Ovid), EMBASE (Ovid), and Cochrane library. Hand searching of top endodontic journals and reference lists of selected studies will be carried out. Selection of studies will be made under predefined inclusion and exclusion criteria. Data extraction of selected studies will be done with two reviewers using a structured data collection form. At the same time, the risk of bias using the Cochrane risk of bias assessment tools will be carried out. A qualitative and quantitative data synthesis will be done. The data will be presented in the form of tables of summary of findings.Discussion All potential clinical, methodological, and patient's related factors responsible for heterogeneity will be explored and discussed. We will also compare the results of our systematic review with existing literature. Strength and limitations of the systematic review will be discussed.Systematic Review registration Our protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO-CRD#42019099141).
Identification of potential targets of microRNA-101-3p in prostate cancer by bioinformatics analysis
Authors: Zhang Jiaojiao , Wang Ke , Bai Ruhai , Liang Hua , Zhang Guanjun , Gong Huilin
Published: December 2019

Background: MiR-101-3p, a tumor suppressor, has been implicated as a tumor suppressor miRNA in multiple primary malignancies including prostate cancer (PCa). This study aimed to explore target genes and relevant signaling pathways regulated by microRNA-101-3p (miR-101-3p) for further researches in PCa with bioinformatics analysis. Results: 565 target genes were appeared in all databases and enriched in positive regulation of transcription, which were mainly enriched in axon guidance and MAPK pathway. Two important modules were detected from PPI network. Ten hub genes were selected, including MAPK1, PIKFYVE, EGFR, SMARCA4, TOP2B, GSK3B, FOS, RAC1, BCL2 and TAF1. After thoroughly reviewing published literature, we found that 10 target genes and six signaling pathways were truly inhibited by miR-101-3p in various tissues or cells; some of these verified targets were in accordance with our present prediction. Conclusion: This study demonstrated that miR-101-3p target hub genes, including MAPK1, PIKFYVE, EGFR, SMARCA4, TOP2B, GSK3B, FOS, RAC1, BCL2 and TAF1, might promote the development of PCa. However, further experiments are still required to confirm potential functions of these miR-101-3p target genes and pathways in PCa.
A novel five-gene signature for predicting prognosis in liver cancer
Authors: Zhong Qiuyue , Shuai Yu , Luo Qiong , Feng Guangyong , Wu Mingna , Fan Erxi , Chen Qiying , Yue Guojun , Zhang Guihai
Published: December 2019

Purpose Liver cancer is one of the most common malignant tumors in China, ranked 5th among the malignant common tumors in the world, which is still difficult to diagnose early and treat effectively. Therefore, exploring some indicators for prognostic prediction is imperative in the treatment of liver cancer. Methods Liver cancer data was obtained from The Cancer Genome Atlas (TCGA). We obtained differentially expressed genes (DEGs) by R software from TCGA database. Risk scores were acquired to assess the weighted gene-expression levels by Cox regression analysis and predict the prognosis of patients with liver cancer. Using the KEGG and GO databases, pathway enrichment was performed by identifying the analysis of DEGs. The display of receiver-operating characteristic (ROC) curves and area under the curve (AUC) could show the validity and the prognostic value of this model in liver cancer. Results In total, 1897 DEGs of transcriptome genes in liver cancer and 1197 DEGs of clinical data were extracted from the TCGA database. We identified a novel five-gene signature associated with liver cancer, including CDCA8, NR0B1, GAGE2A, AC018641.1, and SPANXC. Among of them, CDCA8 and NR0B1 were negatively related to 5-year OS, displaying a worse prognosis (P < 0.05). In particular, we also found that GAGE2A is related to lymphatic metastasis from the clinical data analysis in liver cancer. Receiver-operating characteristic (ROC) curve assessed the accuracy and sensitivity of the gene signature. In the heat map, each of the five genes for patients was presented with the distribution of the risk score. Conclusions We figured out a novel five-gene signature for the prognosis of patients with liver cancer, which may be an effective predictor for patients’ prognosis in the future.
Portrayal of the human blood transcriptome of 3,388 adults and its relation to ageing and health
Authors: Maria Schmidt , Loeffler-Wirth Henry , Hopp Lydia , Arakelyan Arsen , Kirsten Holger , Krohn Knut , Burkhardt Ralph , Wirkner Kerstin , Thiery Joachim , Engel Christoph , Loeffler Markus , Binder Hans
Published: December 2019

Background: The blood transcriptome is expected to provide a detailed picture of organism’s physiological state with potential impact for applications in medical diagnostics and molecular and epidemiological research. We here present the first systematic analysis of blood specimen of 3,388 adult individuals collected in the Leipzig Research Center for Civilization Diseases, together with phenotype characteristics such as disease history, medication status, lifestyle factors and body mass index (BMI). Methods: Multidimensional Self Organizing Maps-portrayal was applied to study transcriptional states on a population-wide scale. The method permits a detailed description and visualization of the molecular heterogeneity of transcriptomes and of their association with different phenotypic features. Results: The diversity of transcriptomes is described by about one dozen modules of co-expressed genes of different functional context. We identify two major blood transcriptome types where type 1 accumulates more men, elderly and overweight people and it upregulates genes associating with inflammation and increased heme metabolism, while type 2 accumulates women, younger and normal weight participants and it associates with activated immune response, transcriptional, ribosomal, mitochondrial and telomere-maintenance cell-functions. We find a striking overlap of signatures shared by multiple diseases, ageing and obesity driven by an underlying common pattern, which reflects the increase in inflammatory processes. Conclusions: Our portrayal framework provides a holistic view on the diversity of the human blood transcriptome. It provides a tool for comparative analyses of transcriptional signatures and of associated phenotypes in population studies and medical applications.
How Iranian men perceive sexual and reproductive health? A qualitative study
Authors: Lotfi Razieh , Azin Seyed Ali , Hatefnia Effat , Amiri Mina , Simbar Masoumeh , Tehrani Fahimeh Ramezani
Published: December 2019

Background Despite the effective role of men in promoting their sexual and reproductive health, they have been often been overlooked for cultural and social issues and limited data are available in this context. In developing countries, the majority of men have limited knowledge and ability in terms of reproductive and sexual health. Hence, this study aimed to investigate male perceptions of sexual and reproductive health concepts.Materials and methods Using the conventional content analysis approach, a qualitative study was conducted on data retrieved through semi-structured interviews with 19 adult males aged 18 to 59 years, purposefully selected from among populations of health centers in the province of Alborz, Iran.Results Three main concepts and 9 categories emerged from the conventional content analysis: 1) Needs including “access to sexual and reproductive health services”, “awareness”, and “high-quality and safe sex”; 2) Responsibilities including “health- seeking behaviors”, “sexual skills”, “childbearing responsibilities” and “ethical commitment”; and 3) Social norms including “gender role attitudes”, and “changing marriage rules”.Conclusion This study showed that structural factors along with cultural and social norms affect sexual and reproductive health in men, who are men not adequately taken care and many of their sexual and reproductive health needs have not yet been addressed. Participants believed that men are responsible for their sexual reproductive health, although they have often difficulties fulfilling their responsibilities because of inadequate knowledge on the subject and the lack of access to sexual/ reproductive health services. Hence, along with socioeconomic changes, the health care system should be prepared to meet these needs and responsibilities using preventive strategies and programs.
Bortezomib in combination with fludarabine and cyclophosphamide for patients with relapsed or refractory mantle-cell lymphoma: results of the LYM-4003 study
Authors: Wang Xiao-xiao , Gao Yan , Jin Jie , Cao Jun-ning , Feng Ji-feng , Wang Hua-qing , Zhang Hui-lai , Cai Qing-qing , Li Zhi-ming , Huang Hui-qiang
Published: December 2019

Background The LYM-4003 study was initiated to identify the maximum tolerated dose (MTD) of cyclophosphamide when combined with bortezomib and fludarabine in a phase 1b trial, and to assess the efficacy and safety of this combination in a phase 2 trial in patients with relapsed or refractory MCL. Methods Patients with relapsed or refractory MCL who had received at least one previous lines of treatment were enrolled in this single-arm, open-label, phase 1/2 trial at six major cancer centers in China. In phase 1, to identify the MTD of cyclophosphamide, 3 patient cohorts received escalating doses (150, 200, and 250 mg/m2) of intravenous cyclophosphamide on days 1, 2 of each 28-day cycle. Patients also received bortezomib 1.3 mg/m2 on days 1, 4, 8 and 11, fludarabine 25 mg/m2 on days 1, 2, 3 of each 28-day cycle. In phase 2 study, patients received bortezomib and fludarabine plus the MTD of cyclophosphamide. Treatment in both phases to maximum 6 cycles of chemotherapy, continued until disease progression, or severe toxicity. The primary endpoint was overall response. The secondary endpoint was survival. We used the Kaplan-Meier method to estimate response duration, progression-free survival, and overall survival. Analysis was by intention to treat population. Results 40 patients were enrolled between April 8, 2011 and October 10, 2015, 9 in phase 1 and 34 (including three patients who received the MTD of cyclophosphamide in phase 1) in phase 2. In phase 1, we identified the MTD as 250 mg/m2 cyclophosphamide. In phase 2, grade 3–4 hematological toxicities included thrombocytopenia, leucopenia, neutropenia, and lymphopenia. Among 32 patients in phase 2, 23 (72%) had an overall response: 10 (31%) had a complete response and 13 (41%) had a partial response. The median follow-up time was 31.6 months. The median response duration was 26.3 months. The median progression-free survival was 21 months (95% CI 7.3–34.7), and the median overall survival was 32.4 months (95% CI 17.8–47.0). Conclusions Bortezomib in combination with fludarabine and cyclophosphamide is highly effective and well tolerated for patients with relapsed or refractory MCL. Trial registration ClinicalTrials.gov NCT01322776 (Registered on March 25, 2011)
Monthly endoscopy surveillance culture facilitates detection of breaches in the scope reprocessing procedure: 5 year-experience in an endoscopy center
Authors: Yen Hsu-Heng , Chen Shu-Hui , Lai Huei-Wen , Chang Hui-Lan , Hsu Yu-Chun , Siao Fu-Yuan
Published: December 2019

AIM To review the clinical impact of monthly microbiology surveillance culture for monitoring endoscope contamination after high-level disinfection.METHODS Monthly surveillance culture of the endoscopes was conducted from January 2014 to December 2018 at our endoscopy center. A total of 1931 cultures were collected, including 765 cultures from 16 gastroscopes, 730 cultures from 18 colonoscopes, 379 cultures from 8 duodenalscopes, 46 cultures from 1 echoscopes, and 11 cultures from 1 enterscope. Cultures were obtained from ready-to-use endoscopes after a full reprocessing cycle and storage. Samples were cultured to test for aerobic and anaerobic bacteria.RESULTS The positive culture rates for the endoscope were 2% (15/765) for gastroscopes, 1.9% (14/730) for colonoscopes, 0.8% (3/379) for duodenscopes, 4.3% (2/46) for echoscopes, and 9.1% (1/11) for enterscopes. These findings were predominantly attributed to human factors (71.4%, 25/35) followed by storage cabinet failure (14.3%, 5/35), automatic endoscope reprocessing failure (11.4%, 4/35), and endoscope channel damage (2.8%, 1/35). Multivariate analysis showed that the years 2015 [odds ratio (OR) 0.19, 0.04 to 0.91], 2016 (OR 0.21, 0.05 to 0.80), and 2017 (OR 0.22, 0.06 to 0.83) were associated with decreased risk of endoscope contamination. The age, type, and number of times the scope was used were not related to contamination.CONCLUSIONS A low risk of endoscope contamination was found over a 5-year period in our endoscopy center. The most common cause of contamination was human factor. Duodenalscopes showed the lowest scope contamination rate. We suggested the implantation of a systematic endoscope culture regardless of the type of scope to facilitate early detection of breaches in the scope reprocessing procedure in clinical practice.
Molecular diversity of Giardia duodenalis, Cryptosporidium spp. and Blastocystis sp. in asymptomatic school children in Leganés, Madrid (Spain)
Authors: Muadica Aly Salimo , Köster Pamela C , Dashti Alejandro , Bailo Begoña , de Mingo Marta Heernández , Reh Lucia , Balasegaram Sooria , Verlander Neville Q , Chércoles Esther Ruiz , Carmena David
Published: December 2019

Background: The protozoa Giardia duodenalis, Cryptosporidium spp., the stramenopile Blastocystis sp. and the microsporidia Enterocytozoon bieneusi are among the most frequent diarrheal pathogens affecting humans globally. This molecular epidemiological study assesses the frequency and molecular diversity of these intestinal parasites in schoolchildren in central Spain, complementing previously published data on risk and protective factors associated with parasite infection (Reh et al., Euro Surveill. 2019;24).Methods: Stool samples were collected from voluntary asymptomatic schoolchildren (4‒14 years) and their siblings (1‒16 years) attending 12 primary and secondary schools in Leganés (Madrid). Initial detection of pathogens was conducted by PCR-based methods targeting the small subunit (ssu) ribosomal RNA or the internal transcribed spacer (ITS) genes of these parasite species. Genotyping of G. duodenalis-positive samples was carried out by PCR and Sanger sequencing of appropriate markers including the glutamate dehydrogenase (gdh), the ß-giardin (bg), and triose phosphate isomerase (tpi) loci. For C. hominis/C. parvum-positive samples the 60-kDa glycoprotein (gp60) locus was used.Results: A total of 1,512 stool samples were analysed. Giardia duodenalis was the most prevalent pathogen (17.4%, 95% CI: 15.5‒19.4%), followed by Blastocystis sp. (13.0%, 95% CI: 11.4‒14.8%), and Cryptosporidium spp. (0.9%, 95% CI: 0.5%‒1.5%). Enterocytozoon bieneusi was not detected. Sequence analyses of the 24 G. duodenalis isolates genotyped at the gdh, bg, and/or tpi loci revealed the presence of sub-assemblages AII (16.6%, 4/24) and BIV (79.2%, 19/24). An additional sequence (4.2%, 1/24) represented an ambiguous BIII/BIV result. Analyses of the 14 Cryptosporidium sequences generated at the ssu rRNA allowed the identification of C. hominis (71.4%; 10/14) and C. parvum (21.4%; 3/14). An additional sequence (7.2%, 1/14) was only identified at the genus level. A total of 162 Blastocystis sp. isolates were successfully genotyped, revealing the presence of five subtypes including ST1 (22.8%; 37/162), ST2 (36.4%; 59/162), ST3 (21.6%; 35/162), ST4 (18.6%; 30/162), and ST8 (0.6%; 1/162).Conclusions: Giardia duodenalis sub-assemblage BIV, Cryptosporidium hominis and Blastocystis ST2 were the genetic variants of these parasite species more prevalent in the asymptomatic schoolchildren population investigated. These findings are very similar to those previously reported in clinical, symptomatic populations in Spain. Enterocytozoon bieneusi was absent in apparently healthy schoolchildren.
Ankstyvojo amžiaus vaikų adaptaciją ikimokyklinio ugdymo įstaigoje lemiantys veiksniai (Kauno miesto atvejis)
Authors: Stoncelyte Raimonda , Masiliauskiene Erika
Published: December 2019

Adaptacija ikimokyklinio ugdymo įstaigoje sudėtingas ir neramus procesas. Vaikas įpratęs laiką leisti su tėvais, būti jų prižiūrimas, todėl šis išsiskyrimas jam labai skausmingas. Ankstyvajame amžiuje vaikui rekomenduojama būti su mama, tačiau dažnai dėl susiklosčiusių aplinkybių nusprendžiama vaiką leisti į ikimokyklinę ugdymo įstaigą. Tėvai šiam procesui ruošiasi iš anksto, o pradėję leisti vaiką į ugdymo įstaigą privalo dirbti kartu su pedagogais. Niekam ne paslaptis, kad rasti laiko kokybiškam ir sėkmingam bendradarbiavimui darosi vis sunkiau. Nepaisant to, tiek tėvai, tiek ugdymo įstaiga turi suprasti, kad juos vienija tas pats tikslas – sėkmingas tolesnis vaiko ugdymas(is). Tyrimo probleminis klausimas – kokie ankstyvojo amžiaus vaikų (iki 3 metų) adaptacijos ikimokyklinio ugdymo įstaigoje ypatumai?Atlikto tyrimo rezultatai atskleidė, kad esminiai ankstyvojo amžiaus vaikų sėkmingos adaptacijos ikimokyklinio ugdymo įstaigoje ypatumai yra šie: nuolatinis keitimasis informacija (tėvai–pedagogai) apie vaiko savijautą; susitarimai dėl adaptaciją lengvinančių priemonių taikymo namuose ir ugdymo institucijoje, taip užtikrinant ugdomųjų veiksmų tęstinumą (grupės aplinka–namų aplinka); periodiniai pedagogų ir tėvų susitikimai adaptacijos klausimams aptarti; abipusis (tėvai–pedagogai) pasitikėjimas ir pagalba.
Integrated financing model in Islamic microfinance institutions for agriculture and fisheries sector
Authors: Zainul Anwar Aan , Susilo Edi , Rohman Fatchur , Budi Santosa Purbayu , Yusuf Agung Gunanto Edy
Published: December 2019

The uniqueness of micro, small and medium enterprises (MSMEs) in the agriculture and fisheries sector has led to thoughts of innovation in the microfinance institutions (MFIs) that serve it. Service innovations in the agriculture and fisheries sector have been carried out in various countries to facilitate the development of this sector. This study aims to analyze the financing model of Islamic microfinance institutions (Islamic MFIs) based on the characteristics of the agriculture and fisheries sectors and the reconstruction of Salam contracts of Islamic financial institutions for farmers and fishermen. The research method used is qualitative descriptive analysis. The data were obtained through in-depth interviews with the agriculture and fisheries businesses in Central Java, Indonesia. The result showed that Salam contract constructed according to the characteristics of the fishing community to alleviate it from the shackles of moneylenders and wholesalers, including Islamic MFIs, farmers, and fishers as members of Islamic MFIs, buyers, Islamic banks and Islamic insurance. The output of this research is that farmers and fishermen can form a community to help one another with financial needs and are managed by Islamic MFIs that work in synergy with fisheries and agriculture companies, as well as an integrated Salam contract application system for Islamic MFIs.
AS TÉCNICAS DA SINALIZAÇÃO E DO JULGAMENTO-ALERTA DE SUPERAÇÃO DO PRECEDENTE JUDICIAL: ESTUDO DE CASO
Authors: Marques Elmer Da Silva , De Aguiar Guilherme Machado , Sulzbach Juliane Gloria
Published: December 2019

O presente artigo tem por objetivo a análise de decisão proferida pelo STF na qual a Corte anunciou a possibilidade de rever o entendimento sobre determinada questão jurídica que vinha, até então, sendo aplicada de forma pacífica. Especial atenção será dada à reação dos Ministros do STF à tentativa de superação de entendimento promovida pelo Ministro Dias Toffoli, bem como às consequências jurídicas que se poderiam inferir da manifestação dos demais Ministros, naquele julgamento, no âmbito de um sistema de precedentes judiciais obrigatórios.
Heidegger: El dolor, el nihilismo y la línea de la Metafísica, entre Überwindung y Verwindung
Authors: Cattaneo Rodríguez Gianfranco
Published: December 2019

El presente texto tiene por objeto mostrar que en el pensamiento de Heidegger existe una teorización acerca del dolor que aflige al hombre moderno debido a su relación inconmovible con la técnica y una indicación para que este pueda sanar de él. Destinado a la Metafísica, en el dolor el hombre experimenta lo sin cura, lo que le exige pensar la topología del don del ser. Dolor y convalecencia son expuestos, así, a la luz de la vuelta [die Khere], del acontecimiento [Ereignis] y de la línea entre la superación [Überwindung] y la torsión [Verwindung] la Metafísica, con el fin de sostener, con Heidegger, que en el dolor se evidencia la pasión de nuestra propia finitud, la experiencia del darse del ser y del cuidado de la nada. El dolor muestra que antes que superar [überwunden] la Metafísica, esta debe ser restablecida [verwunden] en su verdad.
Silogística intermedia, términos y árboles
Authors: Castro-Manzano J. Martín
Published: December 2019

En este trabajo proponemos un método de árboles para la silogística intermedia de Peterson y Thompson usando el álgebra de Sommers y Englebretsen. El resultado es un método analítico deárboles capaz de modelar inferencia en silogística básica, relacional e intermedia.
Conceptualismo y experiencias contradictorias
Authors: Serrano Nicolás Alejandro
Published: December 2019

En este trabajo ofrezco una respuesta conceptualista al argumento de la ilusión de cascada (Crane 1988a, 1988b) en el marco del debate representacionalista acerca del tipo de contenido de la experiencia perceptiva. En primer lugar, analizo la estructura general del argumento, según la cual el contenido supuestamente contradictorio de ciertas ilusiones ópticas mostraría que el contenido de la experiencia perceptiva es de tipo no-conceptual. En segundo lugar, discuto una serie de respuestas conceptualistas con el fin de mostrar por qué no resultan satisfactorias. Finalmente, defiendo una respuesta conceptualista que denomino “disociativa”, según la cual el contenido de la ilusión de cascada no es de hecho contradictorio.
Hermenéutica del texto judicial: Una construcción desde Ricoeur
Authors: Zuluaga Jaramillo Andrés Felipe
Published: December 2019

En el presente artículo se propone una hermenéutica del texto judicial, con base en Ricoeur. Para lograrlo primero se propone cómo abordar la sentencia como texto, y luego desde el arco hermenéutico propuesto por el filósofo francés argumentar como se da la explicación y la comprensión en la sentencia judicial, todo ello con el propósito de mostrar como en algunos casos la comprensión de sí puede pasar por la hermenéutica realizada al texto judicial.
¿De quién son estos pensamientos? Examinando el modelo top-down de las atribuciones de agencia mental
Authors: López-Silva Pablo
Published: December 2019

Resumen: Las atribuciones de agencia mental se definen como el acto de asignar el inicio o autoría de un pensamiento fenoménico en 1era persona a un agente específico. Este tipo de atribución es fundamental para la producción de la creencia de que los seres humanos somos agentes racionales no solamente en términos conductuales, sino que también cognitivos. La teoría top-down - uno de los enfoques dominantes en la literatura actual -  sugiere que las atribuciones de agencia mental emergen como explicaciones retrospectivas de carácter racional a la ocurrencia de pensamientos fenoménicos en primera persona. De esta forma, la agencia de un pensamiento no es parte de su contenido fenoménico inicial, sino que una categoría impuesta tras un análisis retrospectivo. Tras introducir algunos aspectos básicos sobre la discusión, el presente artículo ofrece una evaluación crítica del modelo top-down con el fin de identificar sus fortalezas y debilidades argumentativas. El artículo concluye que, si bien el modelo posee méritos importantes, éste no está en condiciones de responder a ciertos desafíos conceptuales fundamentales.
AİLE, ÇALIŞMA VE SOSYAL HİZMETLER BAKANLIĞINA BAĞLI KURULUŞLARDA GÖREV YAPAN MESLEK ELEMANLARININ YAŞLILARA YÖNELİK TUTUMLARININ BELİRLENMESİ: ANKARA ÖRNEĞİ
Authors: DUYAN Veli , KOÇ Nur Eda
Published: December 2019

Yaşlı
nüfusun hızla arttığı toplumlarda yaşlı bakım hizmetleri önem kazanmıştır. Bu
alanda çalışan meslek elemanlarının yaşlılara karşı tutumlarının bakım
hizmetlerinin kalitesini doğrudan etkilediği bilinmektedir. Meslek elemanları
eğitim almalarına rağmen içinde bulundukları toplumun sosyo-kültürel
özelliklerinden etkilenerek kalıp yargılar ve tutumlar geliştirmektedirler. Bu
nedenle yaşlılara yönelik tutumlarının belirlenmesi önem arz etmektedir. Bu
çalışmanın amacı Aile ve Sosyal Politikalar Bakanlığına bağlı kuruluşlarda
görev yapan meslek elemanlarının yaşlılara karşı tutumlarını belirlemektir.

Veriler
268 katılımcı ile yüz yüze görüşülerek anket yoluyla toplanmıştır. Verilerin
toplanmasında Demografik Bilgi Formu ve Kogan’ın geliştirmiş olduğu Yaşlılara
Yönelik Tutum Ölçeği uygulanmıştır. Çalışma betimleyici ve kesitsel nitelik
taşımaktadır. Sonuçlar SPSS 16 istatistik programı ile değerlendirilmiştir.
Değişkenler arasındaki ilişki ve anlamlı bir farklılık olup olmadığının
belirlenmesi için t-testi ve Varyans Analizi (Anova) kullanılmıştır.

Meslek
elemanlarının yaşlılara yönelik tutumlarının gönüllü olarak yaşlılara hizmet
veren bir kuruluşta çalışıyor olma veya gelecekte böyle bir kuruluşta çalışma
isteğinin, yaşlılık alanında çalışma durumlarından pozitif yönde etkilendiği
belirlenmiştir. Mesleklere göre yaşlılara yönelik tutumun pozitiften negatife
doğru sıralamanın psikolog, sosyal hizmet uzmanı, öğretmen, çocuk gelişimci ve
sağlık servisinde çalışanlar şeklinde olduğu tespit edilmiştir.
BEŞ YAŞ ALTI ÖLÜMÜ ÜZERİNDE YOKSULLUK VE SAĞLIKTA DÖNÜŞÜM PROGRAMININ ETKİSİ
Authors: ŞANTAŞ Fatih
Published: December 2019

Bu
araştırmanın amacı, beş yaş altı ölümünün seyrinin incelenmesi ve yoksulluğun, Sağlıkta
Dönüşüm Programının, sosyo-demografik ve sosyo-ekonomik faktörlerin beş yaş
altı ölümü üzerindeki etkisinin incelenmesidir. Araştırmada, Hacettepe
Üniversitesi Nüfus Etütleri Enstitüsü tarafından 5 yılda bir gerçekleştirilen
“Türkiye Nüfus ve Sağlık Araştırması” verileri kullanılmıştır. Türkiye
Nüfus ve Sağlık Araştırmalarında “Hanehalkı Soru Kâğıdı” ve doğurgan yaşlardaki
(15-49) kadınlar için “Kadın Soru Kâğıdı” kullanılmaktadır. 1993-1998-2003-2008
Türkiye Nüfus ve Sağlık Araştırmalarında (TNSA) evreni 15-49 yaş aralığında en
az bir kez evlenmiş kadınlar, 2013 TNSA’da ise evreni, 15-49 yaş arasındaki tüm
kadınlar oluşturmaktadır. Araştırmalarda örneklem seçiminde ağırlıklı, çok
aşamalı, tabakalı küme örneklemesi yöntemleri kullanılmıştır. 1993 çalışmasının
örneklemini 6519, 1998 çalışmasının 8576, 2003 çalışmasının 8075, 2008
çalışmasının 7405 ve 2013 çalışmasının ise 9746 kadın oluşturmaktadır. Araştırma
sonucunda yoksulluğun, sağlıkta dönüşüm programının ve çeşitli sosyo-demografik
ve sosyo-ekonomik faktörlerin beş yaş ölümünü etkilediği belirlenmiştir.
Pedagogical Conditions for Improving the Health of Senior Pupils Doing Athletics in Institutions of Additional Sport Education
Authors: Kondratov Alexander , Zhukov Rodion
Published: December 2019

The present research featured the pedagogical conditions for improving the health of senior pupils that are doing athletics in institutions of additional sport education. The research objective was to justify the pedagogical conditions of health promotion for high school students involved in sports. The research methods included: analysis and synthesis of scientific and methodological literature data; methods for assessing physical development (anthropometry, methods of studying posture), functional state of body (pulsometry, dynamometry), psychophysiological state, psychodynamic functions, physical qualities (testing), psychosocial studies (conversations, questionnaires), and methods of statistical processing. The research resulted in a pedagogical model of conditions that can strengthen the health of senior pupils involved in additional sport education. The authors studied and experimentally verified pedagogical conditions of health promotion for senior pupils doing track and field athletics. They proved that the ideal pedagogical conditions should meet the following requirements. First of all, one has to define the necessary organizational, information-educational, and educational-motivational measures. Second, the procedure requires a comprehensive psychological, pedagogical, and physiological monitoring of health indicators of pupils. Finally, one should define criteria for evaluating the effectiveness of the educational process.
Content Characteristics of Monitoring of Mental Development in Preschoolers
Authors: Lapteva Yulia , Fedorova Nina
Published: December 2019

The paper features the organization of children mental development monitoring as a part of system-integrated approach in psychological and pedagogic support of preschoolers. The authors substantiate the need to develop content and technological aspects of monitoring the mental development of preschool children, which corresponds with the Preschool Education Federal Educational Standard. The authors regard monitoring as a systematic instrument and a key-condition of psychological and pedagogical support of preschoolers in modern kindergartens. The paper introduces an analysis of theoretical approaches to studying substantial characteristics of monitoring of children’s mental development. Monitoring, as opposed to diagnostic, helps to define the statistic view of the result of mental development of children and its dynamics. Monitoring of mental development of children is a systematic instrument which makes it possible to conduct complex studies and evaluate the main directions of mental development of preschoolers. It also helps to examine the criteria of development, as well as children’s individual achievements in the context of their morphofunctional abilities and social situation. The authors analyzed various ways of diagnosing criteria of children’s mental development and the social situation in a kindergarten group. The paper introduces statistic data of the results of experimental testing of a monitoring program of children’s mental development in kindergartens of Novokuznetsk. The effective use of monitoring of children's mental development is provided by the professional competence of teaching staff. In addition, there must be a network interaction of kindergartens to implement the system of psychological and pedagogical support of children.
Criticism of E. Husserl's Naturalism and the Problem of the Lifeworld
Authors: Kozin Sergey , Medvedeva Oksana
Published: December 2019

The paper features the term "lifeworld" coined in 1910 by E. Husserl. The research objective was to describe the ideological content of Husserl's phenomenology, which determined the content and categorical design (type) of phenomenological sociology. E. Husserl introduced a systematic concept of the "lifeworld" and used it as a basis for a branch of social science now referred to as "understanding sociology". In addition, Husserl’s socio-philosophical and epistemological research helped to resolve the "crisis" of science, which he himself discovered, and to recreate the trampled dignity of human subjectivity. The research generalizes and clarifies various scientific views on the criticism of E. Husserl's naturalism and the problem of "lifeworld". Its results can be used in courses of sociology, philosophy, and history.
Specifics of Hormonal Status in Combined Dishormonal Pathology of the Uterus and Mammary Glands in Reproductive Age
Authors: Shelygin Mikhail S. , Guziy Nadezhda S. , Kaplitskaya Viktoria S.
Published: December 2019

The combined dyshormonal pathology of the uterus and mammary glands represents a great danger to the health of a woman, as well as impairs the quality of life, reduces the reproductive capacity of a woman and leads to premature loss of reproductive function. Steroid hormones play a large role in the regulation of proliferative changes in the uterus and mammary glands. Regulation of target organs, uterus and mammary glands, due to the presence of common mechanisms associated with the presence of the receptor apparatus in the tissues of these organs to sex hormones. The general links of pathogenesis and the high frequency of combined pathology of the uterus and mammary glands are of interest to study not only isolated forms of proliferation, but also the development of a unified systematic approach to the study of this pathology. In recent times, there are opposing views on the role of hormonal dysfunction as a factor in proliferative processes. The management tactics of patients with pathological changes in the mammary gland in various gynecological diseases is an assessment of endocrine status, normalization of hormonal and metabolic disorders, especially when progesterone and cortisol are excreted, testosterone levels are increased, and hyperprolactinemia is affected. Special attention should be paid to patients with menstrual disorders, reproductive health disorders. We believe that the problem of the hyperproliferative processes of the uterus and mammary glands should not be considered only from the perspective of gynecological or mammological practice. This pathology is polymorphic and should have broad interdisciplinary connections with such disciplines as oncology, endocrinology, gastroenterology, psychiatry, therapy, pathomorphology, histology, obstetrics and gynecology. Only by studying all possible links of etiopathogenesis, by combining interdisciplinary communication, it is possible to effectively fight for the quality of patients with a combined pathology of the uterus and mammary glands. Family planning, prevention of unplanned pregnancy, timely implementation of maternity, prevention of miscarriage, the use of modern contraceptives, support for breastfeeding is also of high importance for the prevention of disorders and the preservation, extension of reproductive capabilities, and the prevention of combined dyshormonal pathology of the uterus and breast.
Development of medical insurance in the Russian Federation. At the crossroads. What's next?
Authors: Akulin Igor M. , Zhiguleva Lubov Yu.
Published: December 2019

The RF health care reform is gaining momentum. A thorough consideration should be given to the discussion on the need to exclude health insurance companies from the compulsory health insurance system (CHI). Formation of the National Health Care System of Russia is the main problem of the national health care at this stage of reforms. Additional payment for medical services in the CHI by the general public is not advisable. Changes in the regulatory framework of the CHI system is deemed to be the basis for reforming the system of compulsory and voluntary health insurance in Russia.
Análise de medidas de eficiência térmica no consumo energético e conforto térmico de uma edificação
Authors: CHEPP Ellen David , GASPARIN Fabiano Perin
Published: December 2019

O uso eficiente e racional de energia pode ser promovido através de melhorias construtivas na envoltória de edificações e utilização de equipamentos mais eficientes. Com base nessa diretriz, o objetivo deste trabalho foi avaliar o impacto no consumo energético de medidas de melhoria no desempenho térmico da envoltória de uma edificação localizada em Porto Alegre (RS, Brasil). Foi realizada uma simulação anual de desempenho energético utilizando os programas computacionais SketchUp e EnergyPlus. A edificação projetada seguindo as práticas comuns serviu de base comparativa para a análise da adição de medidas de eficiência na envoltória. Verificou-se que paredes duplas, telhado branco e vidros duplos foram as medidas que tiveram menor impacto na redução do consumo. A aplicação de isolante térmico no forro e nas paredes contribuiu para uma redução de 33,1% e 22,2%, respectivamente, no consumo de climatização. A simulação de um caso ótimo resultou em uma redução de 60,7% no consumo anual de climatização. Portanto, a adição de medidas de isolamento na envoltória de uma edificação tem resultados significativos na redução do consumo energético, o que deveria pautar o desenvolvimento de políticas públicas que incentivem e promovam a aplicação dessas medidas.
Isolamento on farm de Trichoderma: uma ferramenta no controle de doenças de solo para os agricultores no Brasil
Authors: BERNARDO Janaina Tauil , AGUILERA Jorge Gonzalez , SILVA Roberto Balbino da , VIAN Rogério , NIELLA Givaldo Rocha , ULHOA Cirano José , MEDEIROS Ícaro Raoni Ecke
Published: December 2019

Fungos do gênero Trichoderma são amplamente distribuídos pelo seu hábito cosmopolita. Estes fungos vêm sendo empregados como excelentes biopesticidas de fitopatógenos nas principais culturas comerciais. A produção de enzimas que degradam a parede celular, assim como a produção de sustâncias tóxicas fazem deles ótimos inibidores do desenvolvimento de fungos fitopatogênicos. A coleta e uso de isolados próximos das lavouras constitui uma excelente estratégia de controle. Não entanto, o produtor desconhece muitas vezes como fazer este tipo de manejo sem causar prejuízo na lavoura. O nosso trabalho mostra uma estratégia de isolamento de Trichoderma no campo em áreas de soja e de cana-de-açúcar com histórico de doenças radiculares. Cuidados e manejos após a coleta do fungo também são indicados. A experiência obtida em dois locais (Mineiros – Goiás e Mamanguape – Paraíba) em condições ambientais diferentes mostra a importância desta estratégia de isolamento como ferramenta de controle on farm para os agricultores brasileiros. Diferentes produtos ou vias de multiplicação são descritas, mostrando a diversidade do manejo que pode ser estabelecido. Os resultados mostram a efetividade do método descrito como uma ferramenta que poderá auxiliar os agricultores na produção on farm desse fungo.
Antarctic Skuas as bioindicators of local and global mercury contamination
Authors: COSTA Erli Schneider , SANTOS Maria Mercedes , CORIA Nestor Rubem , TORRES João Paulo Machado , MALM Olaf , ALVES Maria Alice dos Santos
Published: December 2019

Mercury (Hg) is a non-essential metal, sometimes extremely toxic, and its presence in the food-web may threaten the wildlife. In seabirds, even low levels of Hg can reduce egg production and the chances of embryos and chicks survival; high levels of this element lead to erratic behavior, loss of appetite and weight, and cellular damages in organs as kidneys can be detected. According to some authors, among 50 to 93% of the total Hg accumulated by the birds through diet can be excreted throughout the feathers during the molting process. In this way, feathers can be used as an excellent non-invasive biomonitor. The objective of this paper was to compared mercury (Hg) levels in feathers of adults and chicks of Catharacta maccormicki(Cma) and C. lonnbergi (Clo) sampled in the Antarctic Peninsula, to identify biomonitors of Hg to the region using non-invasive samples methods. We found Hg significantly higher levels in adults of Cma comparing with Clo adults (U'=841.00, p<0.01) and also with chicks of both species (q>3.398, p<0.01).  We did not find significant differences comparing Clo adults and chicks of both species (U'=16.00, p<0.05), and comparing Cma breeding in different areas (q>3.398, p<0.05) or Clo (U'= 62.00, p < 0.05). The Hg levels variation may be justified mainly by differences in migration patterns. The adults of the species that migrate to more polluted areas (Cma) presented the highest levels of Hg and can be considered a promising indicator of global contamination. In another way, Clo and chicks of both species are good indicators of local Hg contamination, suffering the direct influence of contamination in the Antarctic environment.
Aspectos da política de formação continuada de professores implementada pelos CEFAPROs de Mato Grosso
Authors: Mello Angela Rita Christofolo de , Silva Albina Pereira de Pinho , Taborda Cleuza Regina Balan
Published: December 2019

O artigo publiciza resultados de uma pesquisa de abordagem qualitativa, que analisou, de forma interpretativa, a política de formação continuada ofertada aos professores, pela via dos Centros de Formação e Atualização dos Profissionais da Educação Básica (CEFAPROs) de Mato Grosso, nos últimos dez anos. Para tanto, investigou-se se o trabalho realizado pelos Centros foi reconhecido pelos docentes, como também, se as propostas formativas atenderam as demandas de formação continuada destes. Concluiu-se que os diferentes e contraditórios dilemas e perspectivas apontados pelos professores são inúmeros.  As informações retrataram um contexto adverso e conflituoso. Contudo, a conjuntura analisada, dentre outros aspectos, reedita que a oferta de formação continuada, necessariamente pauta-se nas reflexões das ações realizadas pelos professores no interior das salas de aulas. Apreende-se, portanto, que os professores precisam ter autonomia para planejarem a formação em atenção às suas demandas formativa.
A agonia de Eros:
Authors: Habowski Adilson Cristiano , Conte Elaine
Published: December 2019

Resenha da obra: HAN, Byung-Chul. Agonia do Eros. Tradução de Enio Paulo Giachini. Petrópolis, RJ: Vozes, 2017, 93p.
Currículo e pensamento epistemológico na graduação
Authors: Garcia Joe
Published: December 2019

Este artigo apresenta uma investigação teórica sobre currículo, no contexto da educação superior, tendo por objetivo elaborar um conjunto de proposições curriculares para o desenvolvimento do pensamento epistêmico de estudantes em cursos de graduação. A fundamentação teórica explora particularmente os escritos de Perry (1970), Hofer (2001) e Schommer (1990). O desenvolvimento metodológico da pesquisa utilizou a abordagem de investigação integrada, originalmente proposta por Cooper (1984), que possibilita elaborar um conjunto de proposições teóricas a partir de um corpus de pesquisas sobre determinado tema. O texto inicia explorando o conceito de pensamento epistemológico, no contexto da educação superior. Em seguida elabora e analisa um conjunto de proposições curriculares para o desenvolvimento do pensamento epistêmico dos estudantes. Os resultados destacam a importância do currículo englobar atividades para pensar conceitos sob diferentes perspectivas, promover o pensamento independente, explorar situações de aprendizagem aberta e analisar a construção de argumentos, bem como aprendizagem baseada em projetos e de avaliação com respostas abertas.
Antipsychotic Activity Of Ethyl Acetate Extract Of Ficus Benghalensis Linn.
Authors: Wal Ankita , Wal Pranay , Pal Rashmi Saxena , Pal Yogendra
Published: December 2019

Background:

Ficus benghalensis Linn is mentioned to have CNS lively principle and is used for the remedy of various neurological problems.

Objective:

Ficus benghalensis Linn is mentioned to have CNS lively principle and is used for the remedy of various neurological problems. Consequently, the effect of ethyl acetate extract of Ficus benghalensis Linn changed into investigated for its putative antipsychotic interest, the usage of amphetamine challenged rat version. Ketamine (3 mg/kg intraperitoneally) turned into administered acutely to mice as widespread drug.

Material and methods:

Successive extraction of ficus was done in different solvents. Phytochemical screening and toxicity studies were performed. Then the extract was screened for its anti-psychotic potential as Locomotor activity (representing positive symptoms)Forced swim test (representing negative symptoms)Catalepsy Scoring (Horizontal bar test)Compulsive behaviour test.

Result:

The outcomes in spontaneous locomotor activity confirmed that the ethyl acetate extract of the bark of Ficus benghalensis Linn at a dose level of 200 mg/kg, 400 mg/kg, 600 mg/kg, 800 mg/kg, and a 1000 mg/kg confirmed no considerable antipsychotic pastime in amphetamine brought about hyperactivity in mice whilst compared to standard.

Conclusion:

The extract ethyl acetate of Ficus benghalenis Linn bark has showed decreased effect of locomotor activity and increase in catalepsy scoring. Thus it shows anti-psychotic.

:

Extract at a dose stage of 200 mg/kg, 400 mg/kg, 600 mg/kg, 800 mg/kg, and 1000 mg/kg showed a reduced in locomotor activity while as compared to the standard.
Revealing Changes in Curcumin Bioavailability using Vitamin C as an Enhancer by HPLC-MS/MS
Authors: Dai Xufen , Hao Jiaxue , Feng Ying , Wang Jing , Li Qiannan , Ma Cuicui , Wang Xing , Chang Zhongman , Wang Shixiang , Wang Yuxin
Published: December 2019

Background:

Curcumin (CUR), a natural isolated compound from turmeric, helps in
fighting many diseases, but the broad application of curcumin has been limited ascribed to low bioavailability.

Objective:

The aim of this study is to pursue the enhancement of curcumin bioavailability through coadministration
of vitamin C.

Methods:

Such purpose was achieved through the analysis of curcumin pharmacokinetics by highperformance
liquid chromatography coupled with electrospray ionization - tandem mass spectrometry
(HPLC - ESI - MS/MS). The plasma was separated on a C18 reverse-phase column using acetonitrile
and ammonium formate solution (pH 6.5; 2.0 mM) at 0.8 mL/min. MS/MS detection was carried out in
negative mode using mass patterns of m/z 367.0 > 216.7 for curcumin and m/z 265.2 > 223.9 for internal
standard (honokiol).

Results:

Successful application of the proposed method in the pharmacokinetic study presented clear
changes in key pharmacokinetic parameters, including the growth of AUC (0-t) up to 2.4 times, a 2.2-
fold increase of Cmax, 2.2-fold loss of CL, and 1.5-fold diminishment of t1/2.

Conclusion:

An HPLC-ESI-MS/MS method for the determination of curcumin in rat plasma and validated
the improvement of bioavailability of curcumin through co-administration of vitamin C was determined.
These changes were reasoned to the inhibition of lipid peroxidation induced by the use of
vitamin C. Such a simple strategy is possible to become an alternative for enhancing curcumin efficiency
in practice.