КОННЕКТИВНОСТЬ КОРКОВО-ПОДКОРКОВЫХ ЗВЕНЬЕВ ФУНКЦИОНАЛЬНОЙ ДВИГАТЕЛЬНОЙ СИСТЕМЫ У ЗДОРОВЫХ ПРАВШЕЙ И ЛЕВШЕЙ ПО ДАННЫМ МАГНИТНО-РЕЗОНАНСНОЙ ТОМОГРАФИИ
Authors: Штерн (Челяпина) М.В. , Шарова Е.В. , Жаворонкова Л.А. , Болдырева Г.Н. , Струнина Ю.В. , Кулева А.Ю. , Пронин И.Н. 
Published: December 2024

Работа направлена на уточнение вклада подкорковых структур функциональной двигательной системы в обеспечение состояния покоя и двигательной активности правшей и левшей на основе анализа функциональной коннективности фМРТ. У 45 здоровых испытуемых (23 праворуких и 22 леворуких) оценивались функциональные связи между 20 заданными подкорковыми и корковыми областями мозга по данным фМРТ 3Тл исследований в состоянии спокойного бодрствования, а также при сжимании пальцев в кулак раздельно правой и левой рукой. Установлено, что в состоянии покоя подкорковые и корково-подкорковые звенья функциональной двигательной системы характеризуются наибольшим числом достоверных и стабильных показателей меж- и внутриполушарной связанности - при сниженном их количестве у левшей по сравнению с правшами. Отмечается значительное сходство пространственной организации коннективности исследуемых сетей у право- и леворуких испытуемых. Выполнение движения сопряжено с уменьшением числа значимых внутрисетевых связей и большей их сконцентрированностью по сравнению с состоянием покоя. Специфичность латерализации движения проявляется в динамике корковых взаимодействий, более чётко выраженной у правшей. Профиль функциональной моторной асимметрии в норме сопряжён с превалированием подкорковых связей (хвостатого ядра, скорлупы и бледного шара) в доминантном полушарии, акцентированным при выполнении движений.

This work is aimed at clarifying the contribution of the subcortical structures of the functional motor system to ensuring the resting state and motor activity of right-handers and left-handers based on the analysis of fMRI functional connectivity. Functional connections were evaluated in 45 healthy subjects (23 right-handed and 22 left-handed) between 20 preassigned subcortical and cortical brain areas according to 3T fMRI studies in resting state, as well as when clenching fingers into a fist separately with the right and left hands. It has been established that in resting-state the subcortical and cortical-subcortical links of the functional motor system are characterized by the largest number of reliable and stable indicators of inter- and intra-hemispheric connectivity, while their number decreases in left-handers compared to right-handers. A significant similarity in the spatial organization of the studied networks connectivity was revealed in right-handed and left-handed subjects. The movement execution is associated with a decrease in the number of significant intra-network connections and their greater concentration compared to the resting state. The lateralization movement specificity is manifested in the dynamics of cortical interactions, which is more clearly expressed in right-handers. The profile of functional motor asymmetry is normally associated with the prevalence of subcortical connections (Caudate nucleus, putamen, and globus pallidus) in the dominant hemisphere, which is accentuated when performing movements. Keywords: fMRI, connectivity, motor functional system, subcortical structuresFUNCTIONAL MOTOR SYSTEM'S CORTICAL-SUBCORTICAL LINKS IN HEALTHY RIGHT- AND LEFT-HANDERS ACCORDING TO MRI DATA. * Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Science, Moscow, Russia. ** Federal State Autonomous Institution “N.N. Burdenko National Medical Research Center of Neurosurgery”of the Ministry of Health of the Russian Federation, Moscow, Russia. *** Federal Scientific and Clinical Center for Reanimatology and Rehabilitation, Moscow region, Russia. This work is aimed at clarifying the contribution of the subcortical structures of the functional motor system to ensuring the resting state and motor activity of right-handers and left-handers based on the analysis of fMRI functional connectivity. Functional connections were evaluated in 45 healthy subjects (23 right-handed and 22 left-handed) between 20 preassigned subcortical and cortical brain areas according to 3T fMRI studies in resting state, as well as when clenching fingers into a fist separately with the right and left hands. It has been established that in resting-state the subcortical and cortical-subcortical links of the functional motor system are characterized by the largest number of reliable and stable indicators of inter- and intra-hemispheric connectivity, while their number decreases in left-handers compared to right-handers. A significant similarity in the spatial organization of the studied networks connectivity was revealed in right-handed and left-handed subjects. The movement execution is associated with a decrease in the number of significant intra-network connections and their greater concentration compared to the resting state. The lateralization movement specificity is manifested in the dynamics of cortical interactions, which is more clearly expressed in right-handers. The profile of functional motor asymmetry is normally associated with the prevalence of subcortical connections (Caudate nucleus, putamen, and globus pallidus) in the dominant hemisphere, which is accentuated when performing movements.