bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiences of Urinary Incontinence Management in Older Women: A Qualitative Study
Authors: Javanmardifard Sorur , Gheibizadeh Mahin , Shirazi Fatemeh , Zarea Kourosh , Ghodsbin Fariba
Published: January 2022

Introduction

Older women have various experiences regarding the management of urinary incontinence depending on the societies they live in and their cultural backgrounds. The present study aimed to determine older women's experiences in urinary incontinence management.

Methods

The present qualitative study employed a conventional content analysis approach and was conducted in Iran from 2019 to 2020. In this research, the data were collected through face-to-face unstructured in-depth interviews with 22 older women suffering from urinary incontinence selected via purposeful sampling. The interviews were continued until reaching the data saturation point. Data analysis was performed simultaneously with data collection. The interviews were recorded, transcribed, and analyzed through Graneheim and Lundman style content analysis, and data management was done using the MAXQDA software. In order to achieve the accuracy and validity of the study, the Four-Dimensions Criteria (FDC) by Lincoln and Guba, namely credibility, dependability, conformability, and transformability, were considered and used.

Results

This study was conducted on 22 older women suffering from urinary incontinence with the mean age of 66.54 ± 5.76 years. The acquired data were put in four main categories of “resilience” with three subcategories, “change in lifestyle” with six subcategories, “attempt for treatment of the condition” with three subcategories, and “receiving support” with two subcategories.

Conclusion

The study results indicated that the older women suffering from urinary incontinence were resilient against the condition, had changed their lifestyles to manage the condition, and sought treatment. In addition, receiving support from the family and the society played a significant role in the follow-up and management of the condition. The present study findings can help healthcare team members focus on urinary incontinence, design care programs for older women with this condition, and improve their quality of life. Furthermore, focusing on young and middle-aged women's health, providing them with the necessary training for taking care of the genitourinary system, and raising their awareness for preventing urinary incontinence during old ages can be helpful. Moreover, increasing the healthcare team's sensitivity and following the patients up can help diagnose, manage, and treat the condition before exerting adverse impacts on their quality of life.
Stratification of Health Professional Education and Its Funding Disparities: Evidence From China During the Period of 1998–2017
Authors: Gao Wenjuan , Li Wenzhuo , Zang Yue , Zhong Yuxin , Wu Hongbin
Published: January 2022

Background: The finance of health professional education (HPE) is of immense importance for effective and sustainable health systems, yet relevant empirical research was scarce due to the lack of financial data. The study aimed to bridge the gap by presenting the scenario of finance for health professional institutions (HPIs) of different tiers in China and exploring how the stratification of institutions affected their funding disparities.

Methods: The study employed data collected from the Ministry of Education in China, and selected the HPIs mainly based on the World Directory of Medical Schools. The funding levels and disparities of China's HPIs during the period (1998–2017) were analyzed with descriptive statistics, and the indicators of funding per institution and funding per student were both considered. The average funding in HPIs was presented by tiers, and the Gini coefficient and Theil index were employed to describe the differences in financing among HPIs over the span.

Results: The study found that the number of HPIs has kept growing over the past two decades, with both the funding per institution and the funding per student increasing steadily. Specifically, the average funding per institution of the three tiers increased by 31.5 times, 13.4 times, and 10.5 times separately, with the first-tier universities having an absolute advantage compared to lower tiers. As for the financing disparities among HPIs, the Gini coefficient of the funding per institution maintained to be over 0.5, with the third-tier institutions scoring the highest, while the Gini coefficient of the funding per student all ranged approximately from 0.2 to 0.3. Through the decomposition of the inequalities measured by the Theil index, the share of the between-tier difference in per-institution funding grew from 29.7 in 1998 to 77.9% in 2017.

Conclusions: The funding disparities between tiers of HPIs in China gradually became more accentuated, with the top-tier institutions taking up the largest share. Although the stratified development in HPE has posed a challenge to the unified quality assurance of medical personnel training, it may also be regarded as an effective pathway for developing countries like China to achieve stable development in health professional education.
A Multi-Period Curve Fitting Model for Short-Term Prediction of the COVID-19 Spread in the U.S. Metropolitans
Authors: Majeed Bilal , Li Ang , Peng Jiming , Lin Ying
Published: January 2022

The COVID-19 has wreaked havoc upon the world with over 248 million confirmed cases and a death toll of over 5 million. It is alarming that the United States contributes over 18% of these confirmed cases and 14% of the deaths. Researchers have proposed many forecasting models to predict the spread of COVID-19 at the national, state, and county levels. However, due to the large variety in the mitigation policies adopted by various state and local governments; and unpredictable social events during the pandemic, it is incredibly challenging to develop models that can provide accurate long-term forecasting for disease spread. In this paper, to address such a challenge, we introduce a new multi-period curve fitting model to give a short-term prediction of the COVID-19 spread in Metropolitan Statistical Areas (MSA) within the United States. Since most counties/cities within a single MSA usually adopt similar mitigation strategies, this allows us to substantially diminish the variety in adopted mitigation strategies within an MSA. At the same time, the multi-period framework enables us to incorporate the impact of significant social events and mitigation strategies in the model. We also propose a simple heuristic to estimate the COVID-19 fatality based on our spread prediction. Numerical experiments show that the proposed multi-period curve model achieves reasonably high accuracy in the prediction of the confirmed cases and fatality.
Cost-Efficiency Analysis of the Improved Web-Based Planning, Budgeting, and Reporting System (PlanRep) in Tanzania
Authors: Ruhago George M. , Kapologwe Ntuli A. , Ngalesoni Frida N. , Kengia James T. , Kibusi Stephen M. , Kalolo Albino , Kitali Erick J. , Mtatifikolo James D. , Masuha Sutte R. , Kikula Amani , Mtei Gemini
Published: January 2022

Background

Information systems offer unlimited potential for innovation and digitalization of management functions to facilitate citizen participation and improve accountability, transparency, and efficiency in government operations and service delivery. In line with this, for more than one decade, Tanzania implemented an integrated planning, budgeting, and reporting system (PlanRep) that was used to prepare plans and budgets at the local government authorities (LGAs) using a desktop application. In 2017, PlanRep was upgraded to a Web-based system to address several challenges, including poor coordination and high cost involved in the preparation of plans and budgets. However, operational evidence regarding the cost-efficiencies and benefits of shifting to Web-based PlanRep has not been explored. This study aims to address this gap by assessing efficiency gains (in terms of cost and time) of shifting to a Web-based PlanRep system as a tool for the preparation of LGA plans and budgets.

Methods

The study applied a retrospective before-and-after study design whereby quantitative data was used to assess the amount of time and the cost incurred by LGAs when preparing their budget 1 year before the introduction of PlanRep and 1 year after. Parallelly, qualitative data were collected through key informant interviews with selected LGA officials, Regional Secretariats (RSs), President's Office Regional Administration and Local Government (PORALG), and system end-users such as heads of health facilities and schools (primary and secondary). Secondary data was analyzed by comparing time and cost used before and after Web-based PlanRep, while thematic analysis was employed for qualitative data.

Results

The analysis showed a 53% reduction (from USD 3.8 million in 2017/18 to USD 1.8 million in 2018/19) in the total costs LGAs incurred during planning and budgeting after introducing the Web-based PlanRep. The main efficiency gain was related to per diem costs. The analysis also showed significant time saving from an average of 87 days in 2017/18 to only 8 days in 2018/19. PlanRep system end-users also acknowledged that the introduction of Web-based PlanRep has significantly saved their time and costs in preparation of LGA plans and budget.

Conclusion

The introduction of the Web-based planning, budgeting, and reporting systems has resulted in tremendous cost reduction, time savings, transparency, accountability, and workload reduction. The findings offer operational evidence to guide the implementation and scale up of similar systems in countries that share equivalent circumstances like Tanzania.
The Rise of the Guest Editor—Discontinuities of Editorship in Scholarly Publishing
Authors: Knöchelmann Marcel , Hesselmann Felicitas , Reinhart Martin , Schendzielorz Cornelia
Published: January 2022

Scholarly publishing lives on traditioned terminology that gives meaning to subjects such as authors, inhouse editors and external guest editors, artifacts such as articles, journals, special issues, and collected editions, or practices of acquisition, selection, and review. These subjects, artifacts, and practices ground the constitution of scholarly discourse. And yet, the meaning ascribed to each of these terms shifts, blurs, or is disguised as publishing culture shifts, which becomes manifest in new digital publishing technology, new forms of publishing management, and new forms of scholarly knowledge production. As a result, we may come to over- or underestimate changes in scholarly communication based on traditioned but shifting terminology. In this article, we discuss instances of scholarly publishing whose meaning shifted. We showcase the cultural shift that becomes manifest in the new, prolific guest editor. Though the term suggests an established subject, this editorial role crystallizes a new cultural setting of loosened discourse communities and temporal structures, a blurring of publishing genres and, ultimately, the foundations of academic knowledge production.
Assessing the Impact of Fractured Zones Imaged by ERT on Groundwater Model Prediction: A Case Study in a Chalk Aquifer in Voort (Belgium)
Authors: Van Riet Bjarn , Six Simon , Walraevens Kristine , Vandenbohede Alexander , Hermans Thomas
Published: January 2022

Fractured and karst aquifers are important groundwater reservoirs and are widely used to provide drinking water to the population. Because of the presence of the fractures with varying geometry and properties providing preferential flow paths, fractured aquifers are highly heterogeneous and difficult to characterize and model. In this context, geophysical methods can provide relevant spatially distributed data about the presence of fractures, that can be further integrated in hydrological and groundwater models. In this contribution, we present a case study of a groundwater extraction site in a fractured chalk aquifer in Voort (Belgium), used for the production of drinking water. First, the presence of fractures in the vicinity of the extraction site and their orientation is imaged using electrical resistivity tomography. Based on the available data and the objectives of the study, it is chosen to model only the groundwater component and to simplify the unsaturated zone processes through an average recharge rate. Then, the detected fractures are included in the groundwater model to improve the calibration and the predictive capacity of the model. The results show that a set of parallel fractures crosses the modeled area, whose orientation is in accordance with the tectonic setting. Including these fractures in the model, a more satisfactory calibration was achieved, helping to better understand the hydrogeological behavior of the aquifer. Finally, the acquired knowledge is used to propose new management scenarios for the extraction site minimizing its impact.
The Youngbloods. Get Together. Hypercoagulation, Complement, and NET Formation in HIV/SIV Pathogenesis
Authors: Reno Theresa A. , Tarnus Lilas , Tracy Russell , Landay Alan L. , Sereti Irini , Apetrei Cristian , Pandrea Ivona
Published: January 2022

Chronic, systemic T-cell immune activation and inflammation (IA/INFL) have been reported to be associated with disease progression in persons with HIV (PWH) since the inception of the AIDS pandemic. IA/INFL persist in PWH on antiretroviral therapy (ART), despite complete viral suppression and increases their susceptibility to serious non-AIDS events (SNAEs). Increased IA/INFL also occur during pathogenic SIV infections of macaques, while natural hosts of SIVs that control chronic IA/INFL do not progress to AIDS, despite having persistent high viral replication and severe acute CD4+T-cell loss. Moreover, natural hosts of SIVs do not present with SNAEs. Multiple mechanisms drive HIV-associated IA/INFL, including the virus itself, persistent gut dysfunction, coinfections (CMV, HCV, HBV), proinflammatory lipids, ART toxicity, comorbidities, and behavioral factors (diet, smoking, and alcohol). Other mechanisms could also significantly contribute to IA/INFL during HIV/SIV infection, notably, a hypercoagulable state, characterized by elevated coagulation biomarkers, including D-dimer and tissue factor, which can accurately identify patients at risk for thromboembolic events and death. Coagulation biomarkers strongly correlate with INFL and predict the risk of SNAE-induced end-organ damage. Meanwhile, the complement system is also involved in the pathogenesis of HIV comorbidities. Despite prolonged viral suppression, PWH on ART have high plasma levels of C3a. HIV/SIV infections also trigger neutrophil extracellular traps (NETs) formation that contribute to the elimination of viral particles and infected CD4+T-cells. However, as SIV infection progresses, generation of NETs can become excessive, fueling IA/INFL, destruction of multiple immune cells subsets, and microthrombotic events, contributing to further tissue damages and SNAEs. Tackling residual IA/INFL has the potential to improve the clinical course of HIV infection. Therefore, therapeutics targeting new pathways that can fuel IA/INFL such as hypercoagulation, complement activation and excessive formation of NETs might be beneficial for PWH and should be considered and evaluated.
Anxiety and Depressive Symptoms in the New Life With COVID-19: A Comparative Cross-Sectional Study in Japan Rugby Top League Players
Authors: Ojio Yasutaka , Matsunaga Asami , Kawamura Shin , Horiguchi Masanori , Yoshitani Goro , Hatakeyama Kensuke , Amemiya Rei , Kanie Ayako , Fujii Chiyo
Published: January 2022

Objectives: The primary objective is to compare the prevalence of mental health problems, including psychological distress, anxiety and depressive symptoms in Japan Rugby Top League players in the new life with COVID-19 with those evaluated before COVID-19.

Methods: An observational comparative web-based cross-sectional study was employed for Japan Rugby Top League players. We compared the data from 220 Japanese and 7 foreign players during the new life with COVID-19 with the data from before COVID-19, which was obtained from 233 Japanese and 18 foreign players. We measured anxiety and depression symptoms with the validated Kessler-6, which has been widely used in clinical and research settings among different populations. To investigate the distribution of K6 score and whether there are discrete clusters or not, we conducted the two-step cluster analysis.

Results: In the new life with COVID-19, 15.0% of players reported mild symptoms, which was significantly lower than the 32.3% of players before COVID-19. The prevalence of moderate and severe symptoms was 6.7 and 3.5%, respectively, in the group during the new life with the COVID-19, and 4.8 and 5.2% in the pre-COVID-19 group, with no significant difference. A two-step cluster analysis supported the existence of these two qualitatively different clusters in both groups.

Conclusions: With the spread of new lifestyles related to COVID-19, some rugby players may have improved mental health status due to changes in their daily living environment. Such environmental adjustments alone may not have been sufficient to change the mental health status of others. Rugby players or their teams may require mental health professionals and systems that ensure rest, adjust the environment, and sustainably provide more professional care.
Study on Properties of Potassium Sodium Niobate Coating Prepared by High Efficiency Supersonic Plasma Spraying
Authors: Zhou Longlong , Li Xuewu , He Dongyu , Guo Weiling , Huang Yanfei , He Gengchao , Xing Zhiguo , Wang Haidou
Published: January 2022

In order to realize the construction of environmentally friendly potassium sodium niobate ceramic coating on metal surface, potassium sodium niobate ceramic coating was prepared by supersonic plasma spraying technology. The morphology, element extension and phase structure of such coating were investigated. The dielectric and ferroelectric properties were also analyzed. The results show that the coating has good quality and tetragonal phase structure. When test frequency ≥ 2 MHz, the dielectric constant is stable at about 300, and also dielectric loss is stable at about 0.05. The coating exhibits good hysteresis loops under different applied electric fields. When the applied electric field is 16 KV/cm, residual polarization value of as-prepared coating reaches 17.02 μC·cm−2.
How You Teach Matters! An Exploratory Study on the Relationship between Teaching Models and Learning Outcomes in Entrepreneurship Education
Authors: Cascavilla Ilaria , Hahn Davide , Minola Tommaso
Published: January 2022

Although entrepreneurship can be taught in different ways, entrepreneurship education impact studies generally fall short with regard to acknowledging the teaching models of the programs they assess. This severely limits our understanding of how entrepreneurship education actually works. To address this gap, this study describes and implements a procedure to identify the teaching models of entrepreneurship education courses and shows how different teaching models are associated with entrepreneurial learning outcomes. Our analysis is based on a sample of 376 Italian university students who responded to the Global University Entrepreneurial Spirit Students’ Survey (GUESSS) and attended entrepreneurship education courses. We describe and implement a coding procedure that allows us to classify the entrepreneurship courses attended by the respondents into five different teaching models (Supply, Supply–Demand, Demand, Demand–Competence and Competence). We find that courses based on the Supply–Demand, Demand and Demand–Competence Models are associated with better entrepreneurial learning outcomes than those based on the Supply Model. Our findings contribute to the theory and practice of entrepreneurship education program evaluation and design.
Improvement of Gear Durability for an 86 kW Class Agricultural Tractor Transmission by Material Selection
Authors: Baek Seung-Min , Baek Seung-Yun , Jeon Hyeon-Ho , Kim Wan-Soo , Kim Yeon-Soo , Kim Nam-Hyeok , Sim Taeyong , Kim Hyunggun , Kim Yong-Joo
Published: January 2022

This study was conducted to ensure gear durability and design optimal transmission of agricultural tractors. A field test was conducted using an 86 kW agricultural tractor for plow and rotary tillage, which are typical agricultural operations. The field test was completed after about 107 h due to transmission noise and operational problems. As a result of disassembling the transmission, it was found that the range shift A and B gears were damaged. In the case of the range shift A gear, it was judged that plastic deformation occurred due to low contact stress, and the bending stress was low, therefore gear tooth breakage occurred in the range shift B gear. In order to ensure the durability of the transmission, four materials of alloy steel for machine structural use, such as SCr420, SNCM220, SCM822, and SNC815, were selected, and the safety factor and service life according to the gear materials were compared using simulation software. As a result of simulation analysis, SCM822 satisfied the target life value and was selected as a material for change. The damaged range shift A and B gears were changed to SCM822, and an axle dynamometer test was performed for the verification of the modified transmission. After conducting the axle dynamometer test, the transmission was disassembled, and it was confirmed that the range shift A and B gears were in normal condition. Therefore, it was considered that the durability of the transmission was ensured by satisfying the target life requirements of the gears. In the future, the transmission simulation model for 86 kW class agricultural tractor is expected to be utilized for the development of tractor transmissions, cost reduction, and optimal design.
Endophytic Non-Pathogenic Fusarium oxysporum-Derived Dual Benefit for Nematode Management and Improved Banana (Musa spp.) Productivity
Authors: Kisaakye James , Fourie Hendrika , Haukeland Solveig , Kisitu Joseph , Nakimera Solomy , Cortada Laura , Subramanian Sevgan , Coyne Danny
Published: January 2022

The banana weevil (Cosmopolites sordidus) and the burrowing nematode Radopholus similis represent two of the most important pests of bananas. Previously, colonization of banana plants by the non-pathogenic Fusarium oxysporum (isolate V5w2) and the entomopathogenic Beauveria bassiana (isolate WA) have been shown to increase host resistance to various banana pests and diseases. However, there is limited data on how the combined inoculation of these isolates would affect field performance of bananas. In this study, the fungal endophytes were inoculated separately and in combination. Tissue cultured plantlets of cooking banana cultivar Mbwazirume and dessert banana cultivar Grande Naine were inoculated by root drenching with a suspension of 1.0 × 107 spores mL−1 of the endophytes on three occasions, separated 4 weeks apart, before transplanting into the field. Each plantlet was further inoculated with 1800 nematodes, composed primarily of R. similis. Inoculation of banana plants with the fungal endophytes significantly reduced nematode densities by >34%. Similarly, plant toppling was lower in the endophyte-enhanced plants (<16.5%) compared with the control (23.3%). We also observed improved yield of the first crop cycle in the endophyte-enhanced plants, which yielded >11 t ha−1 year−1 versus 9 t ha−1 year−1 achieved in the non-inoculated plants. These findings demonstrate the benefits of fungal endophytes in improving the yield of both cooking and dessert bananas via suppression of nematode densities and nematode-related damage.
Can the Biological Activity of Abandoned Soils Be Changed by the Growth of Paulownia elongata × Paulownia fortunei?—Preliminary Study on a Young Tree Plantation
Authors: Woźniak Małgorzata , Gałązka Anna , Siebielec Grzegorz , Frąc Magdalena
Published: January 2022

Bioenergy crops play an ecologically and economically fundamental role as an alternative to agri-food productions and as renewable energy sources. Thus far, less attention has been given to assessing microbiological indicators of soil quality in bioenergy crops on abandoned land. The current study assessed microbial and biochemical properties of two soils with different textures in agroforestry plantations of Paulownia elongata × Paulownia fortunei, with regard to the analysis of potential for the reclamation and redevelopment of abandoned lands. The soil samples were characterised by measuring microbial biomass C and N, key enzyme activities, and determining the community-level physiological profiles (CLPP) using Biolog EcoPlates. Soil texture, sampling time (June and October), and distance of sampling (0.1 m and 1 m from a tree) had significant effects on microbiological properties. Moreover, dehydrogenases and acid phosphatase activities as well as microbial biomass C and N decreased with distance from the trees, and were significantly higher in the October than in the June. The community-level physiological profiles (CLPP) and diversity indices showed a similar trend to other parameters of biological activity. The results showed that there were significant differences in the AWCD (average well-colour development) of all carbon sources among the Paulownia microbial communities (p < 0.05). In summary, already after one year of tree planting, a statistically significant increase in microbial activity was found, regardless of soil texture, when evaluated by various methods. This proves the value of the Paulownia as fast-growing plant for recultivation and improvement of soil quality on abandoned land.
Assessing the Biofortification of Wheat Plants by Combining a Plant Growth-Promoting Rhizobacterium (PGPR) and Polymeric Fe-Nanoparticles: Allies or Enemies?
Authors: Merinero Manuel , Alcudia Ana , Begines Belén , Martínez Guillermo , Martín-Valero María Jesús , Pérez-Romero Jesús Alberto , Mateos-Naranjo Enrique , Redondo-Gómez Susana , Navarro-Torre Salvadora , Torres Yadir , Merchán Francisco , Rodríguez-Llorente Ignacio D. , Pajuelo Eloísa
Published: January 2022

Biofortification has been widely used to increase mineral nutrients in staple foods, such as wheat (Triticum aestivum). In this study, a new approach has been used by analyzing the effect of inoculation with a plant growth-promoting rhizobacterium (PGPR), namely, Bacillus aryabhattai RSO25 and the addition of 1% (v/v) of organometallic Fe-containing polymeric nanoparticles (FeNPs) alone and in combination. Previously, the minimal inhibitory concentration of FeNPs for the bacterium was determined in order not to inhibit bacterial growth. All treatments had minor effects on seed germination and plant survival. Considering the physiology of plants, several photosynthetic parameters were significantly improved in individual treatments with FeNPs or the bacterium, particularly the efficiency of the photosystem II and the electron transport rate, which is indicative of a better photosynthetic performance. However, at the end of the experiment, a significant effect on final plant growth was not observed in shoots or in roots. When using FeNPs alone, earlier spike outgrow was observed and the final number of spikes increased by 20%. Concerning biofortification, FeNPs increased the concentration of Fe in spikes by 35%. In fact, the total amount of Fe per plant base rose to 215% with regard to the control. Besides, several side effects, such as increased Ca and decreased Na and Zn in spikes, were observed. Furthermore, the treatment with only bacteria decreased Na and Fe accumulation in grains, indicating its inconvenience. On its side, the combined treatment led to intermediate Fe accumulation in spikes, since an antagonist effect between RSO25 and FeNPs was observed. For this reason, the combined treatment was discouraged. In conclusion, of the three treatments tested, FeNPs alone is recommended for achieving efficient Fe biofortification in wheat.
Leaf and Fruit Nutrient Concentration in Rojo Brillante Persimmon Grown under Conventional and Organic Management, and Its Correlation with Fruit Quality Parameters
Authors: Vilhena Nariane Q. , Quiñones Ana , Rodríguez Isabel , Gil Rebeca , Fernández-Serrano Paula , Salvador Alejandra
Published: January 2022

This study aimed to evaluate the concentrations of the main macroelements in leaves and fruit grown following organic and conventional practices, and to relate them to physico-chemical parameters during commercial fruit harvests. Three samplings were carried out during fruit maturation. Nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), and magnesium (Mg) were determined in leaves and in two fruit flesh areas: basal and apical. Weight, color, firmness, soluble tannins (ST), and total soluble solids (TSS) were also evaluated in fruit. During the study period, the lowering leaf N concentration was accompanied by its increment in flesh. Leaf P and K lowered but did not imply changes in these concentrations in fruit. N, P, and K concentrations were higher in the apical area than in the basal flesh. No changes in Ca concentration occurred in leaf, but Ca translocation from the basal to the apical area was detected in fruit. Management affected the concentrations of leaf K and Mg and the fruit N, P and Ca. The agronomic efficiency of the macronutrients in the organic crops was superior to that in the conventional crops. The Ca and Mg and the N/Ca and Ca/(K+Mg) ratios were closely related to color, firmness, TSS, and ST content.
A Two-Year Study on Yield and Yield Components of Maize-White Bean Intercropping Systems under Different Sowing Techniques
Authors: Zhanbota Aidyn , Noor Rana Shahzad , Khan Azeem Iqbal , Wang Gangyi , Waqas Muhammad Mohsin , Shah Adnan Noor , Ullah Sami
Published: January 2022

Food security is directly coupled with enhanced production under optimized cropping intensity. Intercropping is a diversified and sustainable agricultural technique with optimized cropping intensity. Intercropping is used to obtain a higher yield and more balanced products per unit area. This study was performed at Aidyn Research Institute, Nur Sultan, Kazakhstan, in 2018 and 2019 to identify the effects of different sowing patterns on maize-white bean (Zea mays–Phaseolus vulgaris) sowing systems. The field experiment was arranged in a randomized complete block design with three replications. Göynük-98 was used for white beans, and SY Miami was used for maize, with 20 cm and 40 cm row spaces for maize, and 10 cm and 20 cm row spaces for white bean and sole maize, sole white bean, maize-white bean-maize-white bean, maize-white bean-white bean-maize and white bean-maize-maize-white bean sowing systems. The results showed that wide row spacing was better than narrow row spacing in terms of land equivalent ratio (LER) for both maize and white beans, but grain yield was higher in narrow row spacing. Yield items for both maize and white beans showed higher values in intercropping. Grain yield was higher in sole sowing. The maize-white bean-white bean-maize sowing system for maize and the white bean-maize-maize-white bean sowing system for white beans were determined as the best sowing systems according to the yield components.
Cyberattack and Fraud Detection Using Ensemble Stacking
Authors: Soleymanzadeh Raha , Aljasim Mustafa , Qadeer Muhammad Waseem , Kashef Rasha
Published: January 2022

Smart devices are used in the era of the Internet of Things (IoT) to provide efficient and reliable access to services. IoT technology can recognize comprehensive information, reliably deliver information, and intelligently process that information. Modern industrial systems have become increasingly dependent on data networks, control systems, and sensors. The number of IoT devices and the protocols they use has increased, which has led to an increase in attacks. Global operations can be disrupted, and substantial economic losses can be incurred due to these attacks. Cyberattacks have been detected using various techniques, such as deep learning and machine learning. In this paper, we propose an ensemble staking method to effectively reveal cyberattacks in the IoT with high performance. Experiments were conducted on three different datasets: credit card, NSL-KDD, and UNSW datasets. The proposed stacked ensemble classifier outperformed the individual base model classifiers.
Molecular Determinants for OMF Selectivity in Tripartite RND Multidrug Efflux Systems
Authors: Boyer Esther , Dessolin Jean , Lustig Margaux , Decossas Marion , Phan Gilles , Cece Quentin , Durand Grégory , Dubois Véronique , Sansen Joris , Taveau Jean-Christophe , Broutin Isabelle , Daury Laetitia , Lambert Olivier
Published: January 2022

Tripartite multidrug RND efflux systems made of an inner membrane transporter, an outer membrane factor (OMF) and a periplasmic adaptor protein (PAP) form a canal to expel drugs across Gram-negative cell wall. Structures of MexA–MexB–OprM and AcrA–AcrB–TolC, from Pseudomonas aeruginosa and Escherichia coli, respectively, depict a reduced interfacial contact between OMF and PAP, making unclear the comprehension of how OMF is recruited. Here, we show that a Q93R mutation of MexA located in the α-hairpin domain increases antibiotic resistance in the MexAQ93R–MexB–OprM-expressed strain. Electron microscopy single-particle analysis reveals that this mutation promotes the formation of tripartite complexes with OprM and non-cognate components OprN and TolC. Evidence indicates that MexAQ93R self-assembles into a hexameric form, likely due to interprotomer interactions between paired R93 and D113 amino acids. C-terminal deletion of OprM prevents the formation of tripartite complexes when mixed with MexA and MexB components but not when replacing MexA with MexAQ93R. This study reveals the Q93R MexA mutation and the OprM C-terminal peptide as molecular determinants modulating the assembly process efficacy with cognate and non-cognate OMFs, even though they are outside the interfacial contact. It provides insights into how OMF selectivity operates during the formation of the tripartite complex.
Aspirin Reduces Ischemia-Reperfusion Injury Induced Endothelial Cell Damage of Arterial Grafts in a Rodent Model
Authors: Veres Gábor , Benke Kálmán , Stengl Roland , Bai Yang , Stark Klára Aliz , Sayour Alex Ali , Radovits Tamás , Loganathan Sivakkanan , Korkmaz-Icöz Sevil , Karck Matthias , Szabó Gábor
Published: January 2022

Long-term graft patency determines the prognosis of revascularization after coronary artery bypass grafting (CABG). Ischemia-reperfusion (I/R) injury of the graft suffered during harvesting and after implantation might influence graft patency. Aspirin, a nonsteroidal anti-inflammatory drug improves the long-term patency of vein grafts. Whether aspirin has the same effect on arterial grafts is questionable. We aimed to characterize the beneficial effects of aspirin on arterial bypass grafts in a rodent revascularization model. We gave Lewis rats oral pretreatment of either aspirin (n = 8) or saline (n = 8) for 5 days, then aortic arches were explanted and stored in cold preservation solution. The third group (n = 8) was a non-ischemia-reperfusion control. Afterwards the aortic arches were implanted into the abdominal aorta of recipient rats followed by 2 h of reperfusion. Endothelium-dependent vasorelaxation was examined with organ bath experiments. Immunohistochemical staining were carried out. Endothelium-dependent maximal vasorelaxation improved, nitro-oxidative stress and cell apoptosis decreased, and significant endothelial protection was shown in the aspirin preconditioned group, compared to the transplanted control group. Significantly improved endothelial function and reduced I/R injury induced structural damage were observed in free arterial grafts after oral administration of aspirin. Aspirin preconditioning before elective CABG might be beneficial on free arterial graft patency.
Therapeutic Potential of Perillaldehyde in Ameliorating Vulvovaginal Candidiasis by Reducing Vaginal Oxidative Stress and Apoptosis
Authors: Chen Lei , Wang Fei , Qu Su , He Xiaona , Zhu Yongxin , Zhou Yi , Yang Kunlong , Li Yong-Xin , Liu Man , Peng Xue , Tian Jun
Published: January 2022

Vulvovaginal candidiasis (VVC) is one of the most frequent diseases induced by Candida albicans (C. albicans) during pregnancy, which results in enormous pain to women and their partners in daily life. Perillaldehyde (PAE), a natural monoterpenoid, has significant anti-microbial, anti-inflammatory and anti-oxidation effects. Reactive oxygen species (ROS) are key factors for the host to resist the invasion of fungi. However, excess ROS can cause additional damage independent of the pathogen itself, and the mechanism of ROS in VVC has not been investigated. In this murine study, we revealed that C. albicans infection increased the expression of NADPH oxidase 2 (NOX2) and the content of malonaldehyde (MDA). C. albicans inhibited the activity of antioxidant enzymes in the vagina, including superoxide dismutase (SOD), Catalase (CAT), glutathione peroxidase (GSH-PX) and heme oxygenase (HO-1), which were returned to normal levels after treatment with PAE. Furthermore, PAE inhibited the activities of Keap1 and promoted Nrf2 transfer from cytoplasm to nucleus, which were mediated by excessive accumulation of ROS in the VVC mice. In this study, we also indicated that PAE inhibited the apoptosis of vagina cells via Caspase 9- Caspase 7-PARP pathway and prevented the release of IL-1ꞵ in VVC mice. In summary, this study revealed that the treatment of VVC in mice with PAE might be mediated by inhibition of ROS, and established the therapeutic potential of PAE as an antifungal agent for the treatment of VVC.
Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin
Authors: Thomas David Travis , DelCimmuto Nicholas R. , Flack Kyle D. , Stec David E. , Hinds Terry D.
Published: January 2022

Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective weight maintenance. Exercise boosts the production of reactive oxygen species (ROS) and subsequent transient oxidative damage, which also upregulates counterbalancing endogenous antioxidants to protect from ROS-induced damage and inflammation. Exercise elevates heme oxygenase-1 (HO-1) and biliverdin reductase A (BVRA) expression as built-in protective mechanisms, which produce the most potent antioxidant, bilirubin. Together, these mitigate inflammation and adiposity. Moderately raising plasma bilirubin protects in two ways: (1) via its antioxidant capacity to reduce ROS and inflammation, and (2) its newly defined function as a hormone that activates the nuclear receptor transcription factor PPARα. It is now understood that increasing plasma bilirubin can also drive metabolic adaptions, which improve deleterious outcomes of weight gain and obesity, such as inflammation, type II diabetes, and cardiovascular diseases. The main objective of this review is to describe the function of bilirubin as an antioxidant and metabolic hormone and how the HO-1–BVRA–bilirubin–PPARα axis influences inflammation, metabolic function and interacts with exercise to improve outcomes of weight management.
Anti-Inflammatory Effects of (9Z,11E)-13-Oxooctadeca-9,11-dienoic Acid (13-KODE) Derived from Salicornia herbacea L. on Lipopolysaccharide-Stimulated Murine Macrophage via NF-kB and MAPK Inhibition and Nrf2/HO-1 Signaling Activation
Authors: Ko Yu-Chan , Choi Hack Sun , Kim Su-Lim , Yun Bong-Sik , Lee Dong-Sun
Published: January 2022

Glasswort (Salicornia herbacea L.) is a halophyte that exhibits antioxidant and antidiabetic effects. Only a few studies have been conducted on its antioxidant effects. Here, we isolated an antioxidant using an activity-based purification method, and the resulting compound was identified as (9Z,11E)-13-Oxooctadeca-9,11-dienoic acid (13-KODE). We investigated its ability to suppress inflammatory responses and the molecular mechanisms underlying these abilities using lipopolysaccharide-stimulated RAW 264.7 macrophage cells. We studied the anti-inflammatory effects of 13-KODE derived from S. herbacea L on RAW 264.7 macrophages. 13-KODE inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production by suppressing inducible NO synthase and suppressed LPS-induced tumor necrosis factor and interleukin-1β expression in RAW 264.7 macrophages. LPS-mediated nuclear localization of NF-κB and mitogen-activated protein kinase activation were inhibited by 13-KODE. 13-KODE significantly reduced LPS-induced production of reactive oxygen species and increased the expression of nuclear factor erythroid-2 like 2 (Nfe2I2) and heme oxygenase 1. Overall, our results indicate that 13-KODE may have potential for treating inflammation.
Multi-Relational Graph Convolution Network for Service Recommendation in Mashup Development
Authors: Gao Wei , Wu Jian
Published: January 2022

With the rapid development of service-oriented computing, an overwhelming number of web services have been published online. Developers can create mashups that combine one or multiple services to meet complex business requirements. To speed up the mashup development process, recommending suitable services for developers is a vital problem. In this paper, we address the data sparsity and cold-start problems faced in service recommendation, and propose a novel multi-relational graph convolutional network framework (MRGCN) for service recommendation. Specifically, we first construct a multi-relational mashup-service graph with three types of relations, namely composition relation, functional relation, and tagging relation. These three relations are indispensable and complement each other for capturing multi-view information. Then, the three relations in the graph are seamlessly fused with various strategies. Next, graph convolution is performed on the fused multi-relational graph to capture the high-order relational information between mashups and services. Finally, the relevance between mashup requirements and services is predicted based on the learned features on the graph. We conduct extensive experiments on the ProgrammableWeb dataset and demonstrate that our proposed method can outperform state-of-the-art methods in recommending services when only mashup requirements are available.
Feature Importance Analysis for Postural Deformity Detection System Using Explainable Predictive Modeling Technique
Authors: Kim Kwang Hyeon , Choi Woo-Jin , Sohn Moon-Jun
Published: January 2022

This study aimed to analyze feature importance by applying explainable artificial intelligence (XAI) to postural deformity parameters extracted from a computer vision-based posture analysis system (CVPAS). Overall, 140 participants were screened for CVPAS and enrolled. The main data analyzed were shoulder height difference (SHD), wrist height difference (WHD), and pelvic height difference (PHD) extracted using a CVPAS. Standing X-ray imaging and radiographic assessments were performed. Predictive modeling was implemented with XGBoost, random forest regressor, and logistic regression using XAI techniques for global and local feature analyses. Correlation analysis was performed between radiographic assessment and AI evaluation for PHD, SHD, and Cobb angle. Main global features affecting scoliosis were analyzed in the order of importance for PHD (0.18) and ankle height difference (0.06) in predictive modeling. Outstanding local features were PHD, WHD, and KHD that predominantly contributed to the increase in the probability of scoliosis, and the prediction probability of scoliosis was 94%. When the PHD was >3 mm, the probability of scoliosis increased sharply to 85.3%. The paired t-test result for AI and radiographic assessments showed that the SHD, Cobb angle, and scoliosis probability were significant (p < 0.05). Feature importance analysis using XAI to postural deformity parameters extracted from a CVPAS is a useful clinical decision support system for the early detection of posture deformities. PHD was a major parameter for both global and local analyses, and 3 mm was a threshold for significantly increasing the probability of local interpretation of each participant and the prediction of postural deformation, which leads to the prediction of participant-specific scoliosis.
Analysis of Fault Conditions in the Production of Prestressed Concrete Sleepers
Authors: Markulik Štefan , Petrík Jozef , Šolc Marek , Blaško Peter , Palfy Pavol , Sütőová Andrea , Girmanová Lenka
Published: January 2022

Industries demand that their products are high quality with the least number of defects due to the rapid improvement in manufacturing technology. Quality is a critical criterion for evaluation in manufacturing firms. The production of a final product that can meet customer requirements is essential in a sustainable supply chain system to reduce costs, increase productivity and provide high-quality products. The aim of the study is to identify the root cause of defects emerging in the production process of prestressed railway concrete sleepers. Ishikawa diagram and Pareto analysis were used to identify the root cause. The results showed that the cause of the faulty concrete sleeper is the breaking of the bolts, which are supplied by the external provider. Since the supplier refused to accept the complaint, chemical analysis and measuring of hardness and microhardness of bolts were realized. It showed that the hardness of the bolts does not achieve the values, which should be achieved after the declared heat-treatment. As a corrective action, the input control of bolts hardness was proposed as well as establishing the team cooperating with the supplier to improve the heat treatment process, which will be the objective of further study.
Journey to the Market: The Evolution of Biodegradable Drug Delivery Systems
Authors: Zhu Minze , Whittaker Andrew K. , Han Felicity Y. , Smith Maree T.
Published: January 2022

Biodegradable polymers have been used as carriers in drug delivery systems for more than four decades. Early work used crude natural materials for particle fabrication, whereas more recent work has utilized synthetic polymers. Applications include the macroscale, the microscale, and the nanoscale. Since pioneering work in the 1960’s, an array of products that use biodegradable polymers to encapsulate the desired drug payload have been approved for human use by international regulatory agencies. The commercial success of these products has led to further research in the field aimed at bringing forward new formulation types for improved delivery of various small molecule and biologic drugs. Here, we review recent advances in the development of these materials and we provide insight on their drug delivery application. We also address payload encapsulation and drug release mechanisms from biodegradable formulations and their application in approved therapeutic products.