bluuebunny/crossref_metadata_2025 huggingface dataset:
Curative Effect of Yangxin Dingji Capsule Combined With Mexiletine Hydrochloride on Postoperative Arrhythmia and Its Influences on the Vascular Endothelial Function in Coronary Bifurcation Lesions
Authors: Sun Nasha , Chen Wangkun , Wu Yan , Yu Qiyi , Zhou Xia , Guo Bing
Published: August 2022

Objective. The aim of the study is to explore the curative effect of Yangxin Dingji capsule combined with mexiletine hydrochloride on postoperative ventricular arrhythmia (VA) and its influences on vascular endothelial function in coronary bifurcation lesions (CBL). Methods. A total of 110 patients with CBL admitted to the hospital were enrolled as research subjects between January and December 2021. According to the random number table method, they were divided into a combination group and control group, with 55 cases in each group. The control group was treated with mexiletine hydrochloride, while the combination group was additionally treated with Yangxin Dingji capsules. All were continuously treated for 4 weeks. The clinical response rate between the two groups was compared. The frequencies of 24 h paroxysmal atrial fibrillation, premature atrial contraction, and premature ventricular contraction were compared by the Holter monitoring. The whole blood low-shear viscosity, whole blood high-shear viscosity, and fibrinogen (Fb) in both groups were measured by a full-automatic blood flow analyzer. The levels of plasma nitric oxide (NO), endothelin-1 (ET-1), and von Willebrand factor (vWF) were detected by the nitrate reductase method and enzyme-linked immunosorbent assay (ELISA). During treatment, the occurrence of adverse reactions (vomiting, loss of appetite, dry mouth, diarrhea, nausea) in both groups was statistically analyzed. Results. After treatment, the total response rate of treatment in the combination group was significantly higher than that in the control group (

P
<
0.05

). After treatment, frequencies of paroxysmal atrial fibrillation, premature atrial contraction, and premature ventricular contraction in the combination group were significantly lower than those in the control group (

P
<
0.05

). Whole blood low-shear viscosity, whole blood high-shear viscosity, and the Fb level were significantly lower than those in the control group (

P
<
0.05

). After treatment, the NO level in the combination group was significantly higher than that in the control group (

P
<
0.05

), while levels of ET-1 and vWF were significantly lower than those in the control group (

P
<
0.05

). During treatment, there was no significant difference in the total incidence of adverse reactions between the two groups (

P
>
0.05

). Conclusion. Yangxin Dingji capsule combined with mexiletine hydrochloride can significantly improve clinical effects in CBL patients, improve VA and vascular endothelial function, and reduce plasma viscosity without increasing the incidence of adverse reactions.
Prediction Analysis of College Students’ Physical Activity Behavior by Improving Gray Wolf Algorithm and Support Vector Machine
Authors: Wang Minjian
Published: August 2022

Physical exercise for college students is an important means to build a healthy standard of college students and an important way to a healthy campus. In addition to creating good physical fitness, physical exercise has significant effects on improving psychological stress and alleviating psychological problems and mental illnesses among college students. It is important to predict and analyze the physical exercise behavior of college students and explore the positive value of physical exercise for college education. In order to overcome the problem of low accuracy of traditional algorithms in prediction, this paper uses the improved gray wolf algorithm (IGWO) and support vector machine (SVM) for predictive analysis of college students' physical exercise behavior. A nonlinear decreasing convergence factor strategy and an inertia weight strategy are introduced to improve the gray wolf optimization algorithm, which is used to determine the SVM parameters for the purpose of improving the model accuracy. Then, the college students' physical exercise data are input into the model for validation. By constructing a campus behavior data set of college students and conducting experiments, the algorithm achieves 90.45% behavior prediction accuracy, which is better than that of typical prediction models. Finally, individual growth monitoring of college students is targeted to warn students with abnormal behaviors. At the same time, the higher-order information such as physical exercise behavior habits of college students is explored to provide meaningful reference for constructing personalized training.
Application of Moving Target Information Perception Technology in Intelligent Supervision System
Authors: Zhu Mingjiang
Published: August 2022

In order to solve the problems of inaccurate information collection, incomplete information collection, and inconsistency of collected images in traditional sports injury collection methods, an application method of moving target information perception technology in intelligent supervision system is proposed. By judging and analyzing the potential motion damage posture of the motion posture intelligent tracking images, the collected motion intelligence tracking images are judged. The intelligent tracking image matrix can make up for the shortcomings of traditional images that are not connected, complete the identification, detect potential damage in time, and take targeted preventive measures and means. Finally, according to the target detection algorithm and target tracking algorithm, combined with OpenCV computer vision library and QT image library, an intelligent video surveillance target tracking simulation system is developed. The algorithm studied in this paper is to realize the target tracking function of the intelligent video surveillance system. Through the comparison of experimental results, the design method can accurately collect damage attitude information, without calculating continuous values, and the use of three-dimensional images in the positioning process can analyze the damage attitude from multiple angles.
Evaluating the Effect of China’s Carbon Emission Trading Policy on Energy Efficiency of the Construction Industry Based on a Difference‐in‐Differences Method
Authors: Xie Shasha , Wang Jinjing
Published: August 2022

China’s construction industry makes important contributions to energy consumption and pollution emissions. It is significant to improve energy efficiency in the construction industry. Since 2011, the introduction of China’s carbon emission trading policy has had a great impact on energy conservation and emission reduction. The implementation of the carbon emission trading policy provides us with an opportunity to find solutions to improve the energy efficiency of the construction industry (EECI) in China. In this article, the implementation of carbon emission trading is regarded as a quasi‐natural experiment, and the impact of the carbon emission trading policy on the energy efficiency of the construction industry is evaluated by analyzing the panel data related to the energy of the construction industry in 30 provincial regions from 2008 to 2016 through a difference‐in‐differences method. The main conclusions are as follows. First, the carbon emission trading policy can improve EECI. Second, the carbon emission trading policy can achieve the policy effect of improving EECI by optimizing the allocation of construction machinery resources and enhancing regional technical innovation. At the same time, strengthening government environmental regulation can strengthen the policy effect as well. Finally, some policy implications based on the study are proposed.
Application of Arsenic Trioxide-Based Combined Sequential Chemotherapy in Recurrent Resistant and Refractory Ovarian Cancers: A Single-Center, Open Phase II Clinical Study
Authors: Yang Yingchao , Li Xiaoping , Wang Yue , Shen Xiaoyan , Zhao Lijun , Wu Yan , Li Yi , Wang Jianliu , Wei Lihui
Published: August 2022

Objective. Arsenic trioxide (ATO) has been effectively used for the treatment of hematological malignancies and some solid tumors, while ATO effects were not tested clinically in epithelial ovarian cancer (EOC). Methods. Patients with primary or secondary platinum-resistant EOC were enrolled from October 2015 to December 2019. Patients were mainly treated with ATO-based combined sequential chemotherapy as follows: Regimen 1 (ATO combined taxanes weekly therapy); Regimen 2 (ATO + taxanes + 5-fluorouracil + adriamycin ± bevacizumab sequential chemotherapy), for 5 patients platinum-free interval >12 months, added oxaliplatin). Prespecified end points in this cohort included confirmed best overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety. Results. A total of 33 patients were enrolled in this study. After a median follow-up time of 22.1 months (range 5.5–42.9 months), ORR was 42% and DCR was 85%. The overall PFS was 9.5 months (range 1–38.4 months). The main side effect was myelosuppression. Conclusions. ATO-based sequential combined chemotherapy is effective for primary and recurrent drug-resistant EOC patients in clinical phase II trials. The associated side effects could be controlled, while further study is needed.
The Identification of Chinese Herbal Medicine Combination Association Rule Analysis Based on an Improved Apriori Algorithm in Treating Patients with COVID-19 Disease
Authors: Zheng Yanyan , Chen Ying
Published: August 2022

In this work, an improved Apriori algorithm is proposed. The main goal is to improve the processing efficiency of the algorithm, and the idea and process of the Apriori algorithm are optimized. The proposed method is compared with the classical association rule algorithm to verify its effectiveness. Traditional Chinese medicine plays a certain role in the prevention and treatment of COVID-19. In order to deeply mine the association rules between Chinese herbal medicines for the prevention and treatment of COVID-19, this improved Apriori algorithm is applied from the retrieved published scientific literature and the guidelines for the prevention and treatment of COVID-19 published all over China. Based on the representation of traditional Chinese medicine data in binary form, the potential core traditional Chinese medicine combinations in the treatment of COVID-19 are identified. The results of association rules of Chinese herbal medicine data obtained from the real database provide an important reference for the analysis of COVID-19 combined treatment of Chinese herbal medicine.
Distributed Intelligent Learning and Decision Model Based on Logic Predictive Control
Authors: Zhou Yucheng , Lu Wen , Zhang Yingqiu
Published: August 2022

By the method of documentation and logical analysis, based on the data, based on logic and based on the knowledge of three kinds of artificial intelligence in the sports education, the intelligent learning system feedback delay are studied, combined with mobile communication which led to the artificial intelligence online sports games teaching, pattern recognition, and virtual technology combined with innovative teaching interaction and experience. Promoting the development of green PE teaching machine learning can identify the types of PE activities and realize efficient PE learning diagnosis. Intelligent decision support system can identify sports talents and improve the effect of personalized PE teaching evaluation. From the perspective of psychological development and education, the key problems to be solved in the integration of artificial intelligence and physical education are examined. Then, the consistent model predictive control for feedback delay of nonlinear sports learning multiagent system with network induced delay and random communication protocol is studied. Under the communication waiting mechanism designed, each agent has a certain tolerance of delay, and this tolerance can be determined by ensuring the stability of the system. At the same time, a random communication protocol is designed to ensure the ordered communication of the multiagent system. Finally, the effectiveness of the proposed algorithm is verified by numerical simulation. To solve the channel competition access problem of the sports intelligent learning system with special structure feedback delay model predictive control, a dual channel awareness scheduling strategy under the model predictive control framework was proposed, and the distributed threshold strategy of sensors and the priority threshold strategy of controllers were designed. It is proved that the sensor will eventually work at Nash equilibrium point under the policy updating mechanism, and the priority threshold strategy of the controller is better than the traditional independent and identically distributed access strategy. By avoiding the data transmission when the channel status is poor, the channel access of the system is efficient and saves energy.
An Analysis of the Influence of Different Ways of Context Construction on the Teaching Effect of Intensive Reading and Extensive Reading for English Majors
Authors: Quan Lihong
Published: August 2022

Context construction can more effectively put students into the scene and deepen their understanding of reading. The cultivation of students’ comprehensive language use ability is the key teaching activity that English major teachers pay attention to. Language use is closely related to context construction, so it can be said that English teaching cannot leave context creation. In English class, 56.7% of the students have a deep sense of the teachers’ frequent use of context creation, English songs, using facial expressions to do gestures and using objects to create context accounted for 41.3%, 33.7%, and 33.2, respectively. This shows that more than half of the students have a deep feeling about the use of multimedia for context creation. Aiming at the unreasonable design of context creation activities and other problems, this paper provides scientific strategies for teachers to start with modern English teaching. To promote students’ understanding of reading and analyze the teaching effect based on intensive reading and extensive reading so as to improve the teaching quality.
A Genetic Algorithm Model for Human Resource Management Optimization in the Internet Marketing Era
Authors: Li Yi , Linna Wang
Published: August 2022

In the context of the Internet marketing era, rational use of big data for quantitative analysis of human resource management can effectively help each unit better understand the industry talent and analyze the development trend of the industry. Personnel competency is the key factor affecting job performance. The renewable resources in the resource constrained project scheduling problem are transformed into human resources with competency differences through a series of scientific and reasonable methods. A human resource constrained project scheduling problem model emphasizing competency differences is constructed. The most prominent advantage of this model lies in the selection of indicators that can objectively and reasonably evaluate the competency of personnel, and the rigorous and scientific relationship is provided. The complex multiproject double-objective minimization problem of the total construction period and total cost is transformed into a comprehensive index single-objective maximization problem. Then, a mathematical optimization model is established and solved by a genetic algorithm. Finally, the effectiveness of the algorithm is shown by comparing numerical experiments with other algorithms.
Parametric Influences of Geometric Dimensions on High Temperature Mechanical Behaviors and Damage Mechanisms of Ceramic Matrix Composite and Superalloy Double Bolted Joints
Authors: Zhao Shuyuan , Sun Qian , Zhang Yumin , Jia Jin
Published: August 2022

Given multiple material performance advantages, ceramic matrix composite (CMC) material has become one of the most promising hot structural materials used for thermal protection system in hypersonic vehicles. Under harsh thermal exposure of vehicles in flight, the design of connection structure would be a critical issue in improving load-carrying efficiency and ensuring service safety of aircraft structures in service environments. However, little attention was paid on mechanical behavior and its factors affecting the mechanical property of CMC joining at elevated temperature. To address this concern, a 3D finite element model coupled with progressive damage analysis is carried out to predict high temperature tensile properties and failure behavior of single-lap, double-bolt CMC/superalloy joints assembled by two serial protruding-head bolts. In the implementation of progressive damage analysis of 2D plain-woven C/SiC composites, a user-defined subroutine UMAT including a nonlinear constitutive model, 3D Alvaro failure criterion and Tan’s material degradation rule were embedded into the general package ABAQUS® through Fortran program interface. A parametric study considering geometries of joints was performed to evaluate their resultant influence on high temperature tensile behavior and the associated damage mechanisms for the CMC/superalloy double-bolt joint. New findings were provided for full exploitation of high performance through geometric design of ceramic matrix composite hot structure for hypersonic aircraft.
Application of Ergonomics in Product Design Based on Computer-Aided Design
Authors: Wu Changsong
Published: August 2022

At present, China’s social economy has entered a new state of normalized development. Since green economy is the strategic goal pursued by sustainable economic development and the core development trend of the economy, industrial product design focuses on design humanization and green production above. The principle of ergonomics is applied in the design of industrial products, which has the function of optimizing the scientificity of industrial products, which makes industrial products more humanized. This paper firstly analyzes the basic concept of ergonomics, then expounds the thinking of ergonomics in industrial product design, and expounds the specific application of ergonomics in industrial product design.
Intelligent Physical Education Teaching Tracking System Based on Multimedia Data Analysis and Artificial Intelligence
Authors: Cao Feng , Xiang Maojuan , Chen Kaijie , Lei Ming
Published: August 2022

The education system begins a significant dimension characterized by continuous improvement and impacted by technology, society, and cultural developments. This pattern shows the need to enhance physical and athletic scientific training methods. To make the teacher’s role more successful is the usage of computer systems and other computing infrastructure. This article aims to show the use of Information and Communication Technology (ICT) in the national association for physical education. The digitalization consequences in the profession can be synthesized into the following elements: an operating system for learning, application essential to finish actions, findings recording, movement monitoring, video processing, efficiency correlation and synchronization, object tracking and duration measurement systems, and exercise assessment. While physical activity and athletics are realistic activities, current instructional technology is not sufficient. An intelligent physical education tracking system (IPETS) is proposed in this research. This study analyses and investigates the methodology for the formative assessment of athletic knowledge in computer evaluation. During the first segment, the evaluation technique for the athletic education program was presented. The second step of the paper is to understand the contents of the mathematical formula of particular activity based on the complete approaches proposed for the theory of assessment. A different phase of modernizing teaching activities using the computerized quality education for Artificial Intelligence (AI) technology is established in this article. The experimental findings are high in identifying university students’ regular exercise.
A Smooth Jump Point Search Algorithm for Mobile Robots Path Planning Based on a Two-Dimensional Grid Model
Authors: Yang Zhen , Li Junli , Yang Liwei , Chen Hejiang
Published: August 2022

To address the problems of the traditional A

∗

algorithm in solving paths with many expansion nodes, high memory overhead, low operation efficiency, and many path corners, this paper improved the traditional A

∗

algorithm by combining jump point search strategy and adaptive arc optimization strategy. Firstly, to improve the safety of our paths, the risk area of the obstacles was expanded. Then, the A

∗

algorithm was combined with the jump point search strategy to achieve the subnode jump search, reducing the calculation scale and memory overhead, and improving search efficiency. Considering the influence of the density of obstacles on search efficiency, the heuristic function was enhanced according to the special effects of the density of obstacles. Finally, the redundant jump point and adaptive arc optimization strategies were used to shorten the path length further and enhance the initial path’s smoothness. Simulation results showed that our algorithm outperforms traditional A

∗

and literature algorithms in path length, security, and smoothness, and then was further validated and applied in large-scale marine environments and realistic settings.
The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells
Authors: Le Jiamei , Ji Houlin , Pi Peixian , Chen Kaijie , Gu Xuefeng , Ma Yujie , Fu Yi , Sun Yongning , Zhou Xiaoxiao , Wu Hailong
Published: August 2022

Currently, developing therapeutic strategies for chondrosarcoma (CS) remains important. Sennoside A (SA), a dianthrone glycoside from Senna and Rhubarb, is widely used as an irritant laxative, weight-loss agent, or dietary supplement, which possesses various bioactive properties such as laxative, antiobesity, and hypoglycemic activities. For the first time, our results suggested that cell proliferation and metastasis were inhibited by SA in CS SW1353 cells. SA induced cell growth arrest by inhibiting cell proliferation. The changes of N-cadherin and E-cadherin levels, the markers associated with epithelial mesenchymal transition (EMT), suggested the EMT-related mechanism of SA in inhibiting cell metastasis. Besides, SA significantly stimulated apoptosis in CS SW1353 cells, leading to cell death. The increase of Bax/Bcl2 ratio confirmed that the internal mitochondrial pathway of apoptosis was regulated by SA. In addition, the prediction of network pharmacology analysis suggested that the possible pathways of SA treatment for CS included the Wnt signaling pathway. Notably, the protein levels of the components in the Wnt pathway, such as Wnt3a, β-catenin, and c-Myc, were downregulated by SA in CS SW1353 cells. To sum up, these results demonstrated that the suppression of the growth, metastasis and the stimulation of cytotoxicity, and apoptosis mediated by SA in CS SW1353 cells were possibly caused by the inhibition of the Wnt/β-catenin pathway, indicating an underlying therapeutic prospect of SA for chondrosarcoma.
Human Interleukin-1β Profile and Self-Reported Pain Monitoring Using Clear Aligners with or without Acceleration Techniques: A Case Report and Investigational Study
Authors: Pascoal Selma , Gonçalves Aline , Brandão Andreia , Rocha Duarte , Oliveira Sofia , Monteiro Francisca , Carvalho Óscar , Coimbra Susana , Pinho Teresa
Published: August 2022

Introduction. There is a growing demand for more aesthetic, comfortable, and faster orthodontic treatments, and clear aligners emerged as a solution to fulfill this need. However, the effectiveness of clear aligners to treat complex malocclusions is yet contentious. The use of acceleration methods could improve the efficacy of clear aligners by stimulating cells' mechanobiology through numerous pathways, but this hypothesis is still poorly explored. Objective. We aimed to monitor the release profile of an inflammatory marker-the interleukin-1β-and to evaluate its relationship with self-reported pain scores with and without the use of acceleration techniques during an orthodontic treatment requiring difficult tooth movements with clear aligners. Case Report. Here, we report a case of a 46-year-old female patient who presented functional and aesthetic complaints. Intraoral examination revealed a diminished overjet and overbite, rotation of teeth 45 and 24, absence of teeth 25, 35, and 36, buccolingual dislocation of tooth 21, a tendency to a Class III malocclusion, and a 2 mm left deviation of the lower midline. This study is divided into three stimulation phases: no stimulation, mechanical vibration stimulation, and photobiomodulation. Interleukin-1β levels in gingival crevicular fluid samples from the pressure side of six selected teeth were evaluated at four time points after the orthodontic treatment onset. Pain monitoring in those teeth was performed using a visual analogue scale at the same time points. Results. Interleukin-1β protein production peaked 24 h after treatment onset. Complex movements were associated with increased self-reported pain. Conclusion. Clear aligners show limitations in solving complex tooth movements, even when combined with acceleration. The development of customized and programmable stimulation microdevices integrated into “smart aligners,” which could be designed to specifically stimulate the direction of movement and stimulation parameters and could constitute a solution to optimize the orthodontic tooth movement with clear aligners.
Liposome-Encapsulated Bioactive Guttiferone E Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated MH-S Macrophages and Cytotoxicity against Human Cancer Cells
Authors: Dzoyem Jean Paul , Pinnapireddy Shashank Reddy , Fouotsa Hugues , Brüßler Jana , Runkel Frank , Bakowsky Udo
Published: August 2022

Background. Guttiferone E is a naturally occurring polyisoprenylated benzophenone exhibiting a wide range of remarkable biological activities. But its therapeutic application is still limited due to its poor water solubility. This study is aimed at preparing guttiferone E-loaded liposomes and assessing their in vitro cytotoxicity and anti-inflammatory effect. Methods. Liposomes containing guttiferone E were prepared by the thin film hydration method, and the physicochemical characteristics were determined using dynamic light scattering, laser Doppler velocimetry, and atomic force microscopy. The cytotoxicity was assessed by the MTT assay. The fluorometric cyclooxygenase (COX) activity assay kit was used to assess the COX activity while the nitric oxide production was evaluated by the Griess reagent method. Results. The liposomes with a mean size of

183.33
±
17.28
 
nm

were obtained with an entrapment efficiency of 63.86%. Guttiferone E-loaded liposomes successfully decreased the viability of cancer cells. The overall IC50 values varied between 5.46 μg/mL and 22.25 μg/mL. Compared to the untreated control, guttiferone E-loaded liposomes significantly reduced the nitric oxide production and the activity of COX in a concentration-dependent manner. Conclusion. This study indicates that liposomes can be an alternative to overcome the water insolubility issue of the bioactive guttiferone E.
[Retracted] An Intelligent Analysis Model in the Environment of Regional Economic Development and Regional Economic Differences in China Using Big Data Analysis Technology
Authors: Luo Junyin
Published: August 2022

The current and long‐term regional economic imbalance in China requires ongoing attention. To ensure the balanced development of China’s renewable energy, it is therefore important to examine the causes of the differences in China’s renewable energy from a variety of perspectives. The spatial distribution pattern and characteristics of China’s per capita GDP (gross domestic product) from 2012 to 2021 were examined in this study using the exploratory spatial data analysis tool. In addition, it conducts an empirical investigation into the spatial spillover effect of RED and the manufacturing agglomeration in China (regional economic development). The findings indicate that in the eastern region, the total backward link value of the feedback effect of 17 industrial sectors is 0.8524, and in the central region, the value is 0.8139. The real per capita GDP of neighboring provinces will increase by 0.118% for every 1% increase in manufacturing agglomeration level. According to the overall ranking, China’s RED level is very uneven due to a number of factors. We should direct and encourage the manufacturing industry to congregate in various regions, optimize the spatial pattern of manufacturing industry agglomeration, and fully exploit SSE in order to promote China’s RED and reduce the difference in RE.
lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR-7-5p/ACSL4 Axis in Diabetic Retinopathy
Authors: Liu Yu , Zhang Zhengyu , Yang Jing , Wang Jingfan , Wu Yan , Zhu Rongrong , Liu Qinghuai , Xie Ping
Published: August 2022

Accumulating evidence has suggested the significant role of long noncoding RNAs (lncRNA) in regulating ferroptosis, while its regulatory mechanism in diabetic retinopathy (DR) remains unelucidated. In this work, we first demonstrated that lncRNA zinc finger antisense 1 (ZFAS1) is upregulated in high glucose-cultured human retinal endothelial cells (hRECs) and ZFAS1 inhibition attenuated high glucose- (HG-) induced ferroptosis, which was evidenced by cell viability, total iron and ferrous iron levels, reactive oxygen species (ROS) level, and Glutathione Peroxidase 4 (GPX4) expression detection. Mechanistically, we validated that ZFAS1 may act as a competing endogenous RNA by competitively binding with microRNA-7-5p (miR-7-5p) and modulating the expression of its downstream molecule acyl-CoA synthetase long-chain family member 4 (ACSL4), which is now identified as a classic driver gene of ferroptosis process. In conclusion, our results demonstrate that HG-induced ZFAS1 elevation activates ferroptosis in hRECs and the ZFAS1/miR-7-5p/ACSL4 axis may serve as a therapeutic target for endothelial dysfunction in DR.
Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula
Authors: Yan Jing , Tang Yan , Yu Wei , Jiang Lu , Liu Chen , Li Qi , Zhang Zhiqiang , Shao Changlei , Zheng Yang , Liu Xihao , Liu Xincheng
Published: August 2022

Background. Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods. 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results. (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our in vitro experiments confirmed that the JW treatment suppressed caspase3-dependent pyroptosis, hypoxia-inducible factor 1α (HIF1α), and interleukin-1b (IL-1b) in the colon; facilitated the alternative activation of macrophages (Mφs); and inhibited tumor necrosis factor-α (TNFα)-induced reactive oxygen species (ROS) level in intestinal organoids (IOs). Conclusion. The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Function Mechanism of Psychological Driving Factors and Professional Transformation: Migrant Workers to Industrial Workers
Authors: Yang Su , Tang Tianyue , Li Hongyang , Zhu Long , Huang Jiawei
Published: August 2022

With in‐depth development of industrialization and urbanization in China, improving the professional skills and quality of migrant workers in the construction industry has become an important measure to optimize the labor force structure and promote the industry upgrading. Numerous studies have been carried out on this topic, and construction industrial workers with high skills level and professional quality have replaced the professional identity of migrant workers. However, the psychological cognitive mechanism of migrant workers’ occupational role enhancement behavior has not been fully revealed. This study aims to construct a theoretical model of the intention to influence the industrialization of migrant workers in the construction industry based on the frameworks of the theory of planned behavior and risk perception theory, and to explore the key factors and cognitive mechanisms in their transformation into industrial workers in the construction industry. Empirical study using structural equation modeling through field collection of 383 questionnaires from migrant construction workers shows that perceived behavioral control, subjective norm, and behavioral attitude all have significant positive effects on behavioral intention, with decreasing direct effects in descending order of magnitude. Perceived behavioral control also predicts professionalization through the mediation of behavioral intentions, and the newly introduced risk perception factor in the model has a negative inhibitory effect on behavioral intentions and actual behavior. This study validates the important role of psychological intention on the industrialization of migrant workers in the construction industry, providing a new perspective to promote their transformation into industrial workers, and laying the foundation for the modern transformation and sustainable industry development.
Bilateral Proptosis as an Unusual Presentation of Adult-Onset Alveolar-Type Rhabdomyosarcoma of Ethmoid Sinus: A Case Report
Authors: Watanapokasin Natcha , Phattraprayoon Nanthida , Limsiri Thanita , Tungyingyong Praeploy , Ungtrakul Teerapat
Published: August 2022

Rhabdomyosarcoma (RMS) exhibits varying degrees of clinical manifestations, and one of the determining factors is its primary site of origin. Ocular proptosis is an infrequent presentation of parameningeal RMS. The growing tumor in spacious environments such as air-filled sinuses can obscure its early detection, leading to late disease intervention. Among the four subtypes (embryonal, leiomyomatous, sclerosing and spindle cell, and alveolar), the predominant type of RMS in the paranasal sinuses is alveolar. The incidence in adult-onset RMS is relatively low compared with those of children. We herein present a rare case of a 23-year-old man with an unusual presentation of bilateral proptosis from alveolar RMS of the ethmoid sinus. In contrast to our patient, most reported cases of ocular involvement in RMS turned out to be unilateral and responded poorly to treatment. Despite the aggressive behavior of the adult-onset alveolar subtype in comparable reports, our case shows an excellent outcome. Negative FOXO1 fusion status has been recognized in recent studies as a molecular feature inclined toward a favorable outcome in alveolar RMS. The integration of molecular prognostic factors to risk stratification could be advantageous in determining different prognoses and proper management for an individual patient.
Detection of BRCA1 Pathogenic Variant in a 24-Year-Old Endometrial Cancer Patient: Risks of Several Hereditary Tumor Syndromes Assessed Using Germline Multigene Panel Testing
Authors: Wang Xiaofei , Kaneko Keika , Arakawa Hiromi , Habano Eri , Omi Makiko , Nakashima Eri , Kawachi Hiroshi , Tonooka Akiko , Omatsu Kohei , Nomura Hidetaka , Yunokawa Mayu , Kanao Hiroyuki , Takahashi Shunji , Nakajima Takeshi , Ueki Arisa
Published: August 2022

A 24-year-old woman suspected of Lynch syndrome was found to carry a BRCA1 pathogenic variant, based on germline multigene panel testing (MGPT). The patient was diagnosed with endometrial carcinoma and underwent modified radical hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and omentectomy at the age of 23. Based on her father’s history of colorectal cancer and her history of early onset endometrial cancer, mismatch repair protein immunohistochemistry analysis was performed. However, no loss of expression for mismatch repair proteins was found. Given her family history of ovarian and breast cancers, MGPT was recommended to identify the presence of any hereditary tumor syndromes. This testing revealed a BRCA1 pathogenic variant (exon13: c.1016delA, p.Lys339ArgfsX2) and diagnosed as hereditary breast and ovarian cancer syndrome (HBOC). Subsequently, the patient’s mother also underwent single-site analysis for this variant, and the same pathogenic variant was detected. The patient and her mother are at high risk of developing BRCA1-associated HBOC-related cancers. Based on family history, clinical surveillance is currently underway for this patient and her mother. Currently, MGPT offers the potential for comprehensive genetic cancer risk assessment and may provide a more rational approach for the genetic assessment of those individuals whose personal and family cancer histories do not fit neatly into a single syndrome. This case suggests that if a patient is at high risk for hereditary tumor syndromes, MGPT should be considered to improve disease management strategies in clinical settings.
Surgical Repair of the Extrusion of the Body of a PAUL Implant for Glaucoma
Authors: Milla Elena , Izquierdo Jordi , Sanchez Dalmau Bernardo
Published: August 2022

The purpose of our article was to describe a simple but effective surgical technique performed on a patient with an extrusion of part of the body of a PAUL drainage implant for glaucoma. We present the case of a patient with refractory glaucoma and a history of multiple ocular interventions. A PAUL shunt was implanted and in the early postoperative period the patient presented extrusion of part of the implant body. An excessive scarring tissue at the lateral rectus muscle tendon hampered the placement of the lateral wing under the muscle; therefore, we decided to trim a part of it and suture the implant body to the sclera. The surgical technique that satisfactorily resolved the complication is described and shown in a video. This is the first time that such complication is described with the PAUL implant. We suggest that the intrinsic characteristics of the implant, mainly the dimensions, material, and thickness, made it possible for a potentially serious complication such as that described to be solved in a relatively simple and nontraumatic way for the eye.
Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (Carcinoid): Results from the Phase 2 ATLANT Study
Authors: Ferolla Piero , Berruti Alfredo , Spada Francesca , Brizzi Maria Pia , Ibrahim Toni , Marconcini Riccardo , Giuffrida Dario , Amoroso Vito , La Salvia Anna , Vaccaro Vanja , Faggiano Antongiulio , Colao Annamaria , Volante Marco , Ghizzoni Simona , Mazzanti Paola , Houchard Aude , Fazio Nicola
Published: August 2022

Introduction: Lanreotide autogel (LAN) and temozolomide (TMZ) are guidelines-recommended monotherapies for thoracic neuroendocrine tumors (carcinoids; T-NETs), but prospective data for both combined and monotherapies are lacking. ATLANT (NCT02698410) evaluated efficacy and safety of LAN/TMZ in progressive T-NETs. Methods: ATLANT was a 12-month, Italian, phase 2, single-arm, open-label, multicenter pilot study. Eligible patients had unresectable, locally advanced/metastatic, well-/moderately differentiated T-NETs with radiological progression. Patients received subcutaneous LAN 120 mg every 28 days and oral TMZ 250 mg/day for 5 consecutive days every 28-day cycle. Main endpoints are disease control rate (DCR) at 9 months (primary; investigator-assessed), median progression-free survival (PFS), biomarkers, and safety. Results: The number of patients was 40; 60% were male. Primary tumor site was lung (90%) and thymus (10%). Carcinoid type was typical (20.0%) and atypical (52.5%). DCR at 9 months was 35.0% (95% confidence interval (CI) 20.63–51.68; nonacceptability threshold ≤10%, p < 0.0001; not significantly above clinically relevant threshold ≥30%, p = 0.2968). DCR between 7.5 and 10.5 months (sensitivity analysis) was 45.0% (95% CI: 29.26–61.51) and clinically relevant (p = 0.0320 at ≥30% threshold). Median PFS was 37.1 (95% CI: 24.1–52.9) weeks. No association was observed between biomarker variations (chromogranin A, neuron-specific enolase, somatostatin receptor type-2, Ki-67, 6-O-methylguanine-DNA-methyl-transferase) and DCR or PFS. Most patients (97.5%) had treatment-emergent adverse events (TEAEs); 72.5% had treatment-related TEAEs. TEAEs were mainly grade 1/2. No unanticipated TEAEs were reported. Conclusions: This study showed that the LAN/TMZ combination has promising efficacy in progressive T-NETs, and was well tolerated. Larger studies are warranted to support the clinical benefits of LAN/TMZ in patients with T-NETs.
Vírus em viagem: fluxos turísticos globais e propagação pandémica da Covid-19
Authors: Sacramento Octávio
Published: August 2022

Na relação com a Covid-19, o turismo é referenciado sobretudo como uma esfera socioeconômica severamente afetada, não sendo dado o devido relevo ao seu papel  enquanto componente do sistema de condições que desencadeou a pandemia. Perante esta situação, a análise desenvolvida é orientada pelo intuito de perceber como os processos de massificação turística e a abrangente rede de transporte aéreo que pressupõem, gerando conectividades, trânsitos e velocidade sistêmica, contribuíram para a súbita globalização do Sars-CoV-2. Para tal são mobilizados dados resultantes de um processo de pesquisa de teor documental em fontes mediáticas, fontes associadas a grandes instituições internacionais de natureza intergovernamental e fontes científicas. A partir desses dados é possível  depreender-se que os contextos turísticos e as respectivas estruturas de mobilidade são o resultado de complexas assemblagens mais- do-que-humanas nas quais emergem condições sociais, ambientais e tecnológicas que funcionam como poderosos vetores estruturais de rápida difusão transnacional de biocontaminantes, responsáveis, em alguns casos, por cenários pandêmicos como aquele em que vivemos desde março de 2020.
Editorial
Authors: Martins Lilian Al-Chueyr Pereira , Prestes Maria Elice de Brzezinski
Published: August 2022

Editorial da revista
Clinical Outcomes in Basal Ganglia Strokes Treated With Mechanical Thrombectomy
Authors: Bouslama Mehdi , Haussen Diogo C. , Ravindran Krishnan , Liberato Bernardo B. , Bhatt Nirav R. , Navalkele Digvijaya , Bianchi Nicolas A. , Belagaje Samir R. , Frankel Michael R. , Nogueira Raul G.
Published: August 2022

Background

Basal ganglia infarcts are thought to carry worse clinical outcomes compared with other infarct patterns. We aimed to investigate whether pretreatment topographic infarct patterns including complete basal ganglia involvement versus other infarct patterns help predict mechanical thrombectomy outcomes.

Methods

This was a review of a prospectively collected database of consecutive mechanical thrombectomy patients with anterior circulation large vessel occlusion strokes between January 2014 and November 2018. Patients were categorized into the following 2 groups: (1) total basal ganglia (TBG) strokes defined as infarcts affecting both the caudate and lentiform nuclei regardless of cortical involvement and (2) other infarct patterns. Infarct location was assessed on preprocedure noncontrast computed tomography using an automated software (e‐ASPECTS). Baseline characteristics and outcome measures were compared.

Results

A total of 1011 patients were analyzed of which 234 (23.12%) had TBG strokes. Patients with TBG strokes were younger (
P
=0.01); had higher National Institutes of Health Stroke Scale (NIHSS) (
P
=0.006), lower e‐ASPECTS (
P
<0.001), and lower systolic blood pressure (
P
=0.024); and had diabetes less often (
P
=0.01). Baseline characteristics were otherwise comparable between groups. Involvement of the caudate or lentiform nucleus alone was observed in 237 (30.5%) and 21 (2.7%) patients, respectively, in the other infarct patterns group. No internal capsule involvement was detected in either group. There were no differences in terms of 90‐day functional outcomes whether dichotomized (modified Rankin Scale score≤2: TBG=44.6% versus other=50.1%;
P
=0.14) or looking at the entire spectrum of the scale (shift analysis;
P
=0.74). However, TBG strokes had significantly higher rates of any parenchymal hematomas (15.4% versus 8.2%;
P
=0.001), an association that held true in multivariable analysis (adjusted odds ratio, 2.57 [95% CI, 1.41–4.62];
P
=0.002).

Conclusions

Despite increased rates of hemorrhagic transformation, ganglionic infarcts carry similar functional outcomes after mechanical thrombectomy compared with other stroke patterns.
Agenda Setting on FAIR Guidelines in the European Union and the Role of Expert Committees
Authors: Stocker Misha , Stokmans Mia , van Reisen Mirjam
Published: August 2022

The FAIR Guidelines were conceptualised and coined as guidelines for Findable, Accessible, Interoperable and Reusable (FAIR) data at a conference held at the Lorentz Centre in Leiden in 2014. A relatively short period of time after this conference, the FAIR Guidelines made it onto the public policy agenda of the European Union. Following the concept of Kingdon, policy entrepreneurs played a critical role in creating a policy window for this idea to reach the agenda by linking it to the policy of establishing a European Open Science Cloud (EOSC). Tracing the development from idea to policy, this study highlights the critical role that expert committees play in the European Union. The permeability of the complex governance structure is increased by these committees, which allow experts to link up with the institutions and use the committees to launch new ideas. The High Level Expert Groups on the EOSC provided the platform from which the FAIR Guidelines were launched, and this culminated in the adoption of the FAIR Guidelines as a requirement for all European-funded science. As a result, the FAIR Guidelines have become an obligatory part of data management in European-funded research in 2020 and are now followed by other funders worldwide.