bluuebunny/crossref_metadata_2025 huggingface dataset:
Oncocytic variant of central mucoepidermoid carcinoma
Authors: Lima-Verde Maria Elisa Quezado , Ramos Fabrício de Lamare , Nogueira Cleto Dantas , Távora Fábio Rocha Fernandes , Soares Eduardo Costa Studart , Sousa Fabrício Bitu , Mota Mário Rogério Lima , Alves Ana Paula Negreiros Nunes
Published: February 2024

Mucoepidermoid carcinoma constitutes a heterogeneous lesion and may present histological variations that make the diagnosis challenging. This study aims to report a rare diagnosis of central oncocytic mucoepidermoid carcinoma (OMEC). A 45-year-old female patient, presenting a 10-year-old history of increase of volume in the left posterior mandible, with dental displacement and no clinical sign of mucosal involvement. A well- limited hypodense area was observed radiographically, with cortical bone thinning and a discrete area of solution of continuity. Histopathological analysis of incisional biopsy revealed a malignant neoplasia with glandular differentiation, presenting multiple cystic and ductiform spaces and a prominent component of large oncocytic cells, such as cells with squamous, basaloid, and mucous aspects. Histochemical and Immunohistochemical findings contributed to the diagnosis of OMEC. Tumor resection and mandibular reconstruction with microsurgical fibular graft were considered. However, the patient refused the treatment. This is the first report of OMEC with intraosseous occurrence.
Thinking Collectively…or How to Get Something Out of Neoliberal Critique Without (Immediately) Overthrowing the Capitalist System
Authors: Neylon Cameron
Published: February 2024

One of the things I find frustrating about discussions of economics in scholarly publishing is the way that discussions that are built around critique of capital models or neoliberalism are dismissed as impractical. Most recently Stuart Lawsonâ€™s interesting provocation, Against Capital, got a range of dismissive comments as being irrelevant because it required the overthrow of the capitalist system.
Squaring Circles: The economics and governance of scholarly infrastructures
Authors: Neylon Cameron
Published: February 2024

This is a version of the paper I’ve had accepted for SciDataCon in a session on the sustainability of Research Data Infrastructures. It was also the basis for the session that I helped leadÂ with Simon Coles at the Jisc-CNI meeting in mid-July in Oxford. The original version was quite short and skips over some ofÂ the background material and context.
Openness in Scholarship: A return to core values?
Authors: Neylon Cameron
Published: February 2024

This is my submitted paper to ElPub, a conference running in Cyprus over the next few days. I’m posting it here as a kind-of-preprint. Comments and thoughts are welcome. The version in the proceedings is available online as part of Chan and Loizides (eds) Expanding Perspectives on Open Science: Communities, Cultures and Diversity in Concepts and Practices.
Taking Culture Seriously: The challenges of data sharing
Authors: Neylon Cameron
Published: February 2024

I promised some thinking out loud and likely naive and uninformed opinion in my plans for the new year. Here’s a start on that with apologies to Science and Technology Studies and Cultural Studies people who’ve probably thought all of this through.
FORCE11 Executive Board Statement on Restrictions to Immigration
Authors: Neylon Cameron
Published: February 2024

My normal practice is that nothing posted here has been seen orÂ vetted by others.
Speculations: Abstracting Evolution
Authors: Neylon Cameron
Published: February 2024

This post is aiming to get down some thoughts around how the superset of evolutionary models can be framed. It’s almost certainly work that has been done somewhere before but I’m struggling to find it so it seemed useful to lay out what I’m looking for.Â

Evolutionary models are extraordinarily powerful, in part because they are extremely flexible.
Pemberdayaan Desa dengan Keunikan Kemasan Produk pada “One Village One Product” di Kecamatan Bontomarannu
Authors: Geraldina Ira , Arifin Andi Harmoko , Rahim Abdul Rahman , Andriyansah Andriyansah
Published: February 2024

Although faced with various problems, MSMEs in Indonesia have increased every year, in 2021 MSMEs numbered 63, 955, 369 units and in 2022 the number reached 8.71 million units. The partners of this activity are fostered MSMEs in three villages, namely Romang Lompoa, Balang-Balang, and Borongloe Villages, Bontomarannu District, Gowa Regency. The urgency of this activity is to minimise difficulties in marketing, intense business competition The solution given to overcome partner problems is to improve the quality of product packaging for fostered partners and increase sales of fostered partner products. The solution given to overcome partner problems is to improve the quality of product packaging of fostered partners and increase sales of fostered partner products.
Covariação e o conceito de função: objetos dinâmicos
Authors: Lima Jeferson Moizés , Siple Ivanete Zuchi , Aguiar Rogério de
Published: February 2024

Este texto é oriundo de um trabalho de investigação sobre o ensino e aprendizagem do conceito de função com uma abordagem dinâmica de covariação, desenvolvido no Programa de Pós-Graduação em Ensino de Ciências, Matemática e Tecnologias da Universidade do Estado de Santa Catarina. Para tanto, o referencial teórico apresenta a forma como o conceito de função vem sendo abordado e a necessidade de se disponibilizar aos alunos atividades em contextos dinâmicos, ou seja, por meio de objetos de aprendizagem a partir dos quais o estudante possa prever, por intermédio de situações-problemas, o comportamento de grandezas que se modificam ao longo do tempo. Nessa perspectiva, desenvolvemos um produto educacional, um material não convencional como o livro didático, mas sim, um livro dinâmico, denominado “COVARIAÇÃO E O CONCEITO DE FUNÇÃO: objetos dinâmicos”. Nele está inserido atividades que permitem explorar diferentes representações de um mesmo objeto matemático conectados de maneira dinâmica e vinculados ao raciocínio covariacional. Uma das atividades desse produto educacional foi experimentada em uma turma de Ensino Médio. Os resultados alcançados indicam contribuições positivas desse produto educacional para o desenvolvimento do raciocínio covariacional do aluno, no que tange a aprendizagem do conceito de função. Além disso, as atividades inseridas no livro, possuem a intencionalidade de proporcionar, além de simulação de situações-problemas, a transformação concomitante de diferentes registros de representação semiótica, permitindo ao aluno, articular a visualização e a experimentação em um mesmo ambiente, ou seja, na mesma janela de visualização, algo que no ambiente do lápis e do papel seria limitado.
THE USE OF INTEGRATED LEARNING MODEL IN INDONESIAN LANGUAGE: AN ANALYTICAL STUDY OF THE EFFECTIVENESS OF LEARNING PROCESS IN THE MERDEKA CURRICULUM ERA
Authors: Syam Christanto , Effendy Chairil , Martono Martono , Olendo Yudhistira Oscar , Putra Zakarias Aria Widyatama
Published: February 2024

The usage of multiple learning approaches from the remains of the 2013 curriculum cannot be abandoned, especially in the period of Merdeka curriculum. This study builds teacher activities on integrated learning approaches, specifically in Indonesian language acquisition with short story writing material. The relevance of utilizing this model is considered as biased and not in line with the features of learning in the current period. The goal of this study is to demonstrate the efficacy of using an integrated learning in the Merdeka curriculum era. This research is revealed using a qualitative descriptive strategy. In the Merdeka curriculum age, the utilization of an integrated learning strategy for short story writing content is still relevant and aligned with student product objectives. Furthermore, the integrated learning model used by the instructor is effective and efficient, as indicated by the preparation for the organized learning evaluation and alignment with the learning objectives. It should be a source of worry and adaptation for other Indonesian language instructors who wish to continue working with integrated learning models that have the features of learning models in the Merdeka curriculum period.
Modified Hand-Sewn Polytetrafluoroethylene Bicuspid Valved Conduit for the Reconstruction of Right Ventricle Outflow Tract in Truncus Arteriosus in Infancy: A Case Report
Authors: Ma Jianrui , Qiu Hailong , Tian Miao , Xie Wen , Li Ying , Tujia Zichao , Tan Tong , Han Linjiang , Zhou Ziqin , Wen Shusheng , Chen Jimei , Zhuang Jian , Yuan Haiyun , Liu Xiaobing
Published: February 2024

The reconstruction of the right ventricle outflow tract in truncus arteriosus remains challenging. The use of valved conduit based on polytetrafluoroethylene has been increasingly popular since the 1990s. Albeit with verified long-term durability, the previous techniques for manufacturing polytetrafluoroethylene valved conduit were relatively cumbersome and time-cost, which at least in part limited its further application. We reported the first successful truncus arteriosus case using a modified and simplified technique for hand-sewing the polytetrafluoroethylene pulmonary bicuspid valved conduit. Eventually, the patient completed the surgery successfully and showed a satisfactory outcome during the 17-month follow-up. Therefore, this technique is a time-saving, reproducible, and reliable approach in truncus arteriosus on the reconstruction of the right ventricle outflow tract.
Themes of Al-Farabi's Document in Linguistic Evidence Citation Compared to the Methodology of Grammarians: Sibawayh's Book as a Case Study
Authors: Abdeldeen Mahmoud
Published: February 2024

The study aimed to explore how closely grammarians adhered to the standards set by Abu Nasr al-Farabi in his book "Al-Huruf," known as Al-Farabi's Document. These standards outlined the methodology grammarians used in citing Arabic speech to validate their linguistic opinions or grammatical rules. It was expected that Al-Farabi derived these criteria based on the grammarians' methodology in their writings, but this did not entirely match what was observed in grammatical texts. Al-Farabi noted that grammarians did not cite everything from the Arabs; they excluded tribes influenced by other languages, known as the geographical criterion for linguistic evidence. However, the reality shows that grammarians did not strictly follow this criterion. This was evident in the examples cited by Sibawayh in his book, as many poets fell outside Al-Farabi's mentioned scope. This does not indicate a lack of methodology, but rather Sibawayh and subsequent grammarians focused on eloquence and linguistic correctness. Wherever these were present, evidence was cited regardless of the geographical criterion of the speaker. Al-Farabi's description of the grammarians' method seems to be a general overview rather than an accurate extrapolation. Al-Farabi's Document in "Al-Huruf" is more precise to what grammarians did, but less accurate in its content attributed to him by Abu Hayyan and Al-Suyuti, possibly due to their added details to the document's text.
Revolutionizing Healthcare: The Role of Machine Learning in the Health Sector
Authors: Sarker Mithun
Published: February 2024

Traditional healthcare systems have grappled with meeting the diverse needs of millions of patients, resulting in inefficiencies and suboptimal outcomes. However, the emergence of machine learning (ML) has ushered in a transformative paradigm shift towards value-based treatment, empowering healthcare providers to deliver personalized and highly effective care. Modern healthcare equipment and devices now integrate internal applications that collect and store comprehensive patient data, providing a rich resource for ML-driven predictive models. In this research article, we explore the profound impact of ML on contemporary healthcare, emphasizing its potential to significantly enhance patient care and optimize resource allocation. Our study presents a robust predictive model capable of accurately forecasting patient diseases based on input information and various parameters, leveraging extensive datasets encompassing diverse patient populations. We compared several ML algorithms, including Logistic Regression (accuracy: 0.796875), K-Nearest Neighbors (accuracy: 0.7864583333333334), XG Boost (accuracy: 0.78125), and PyTorch (accuracy: 0.7337662337662337), to identify the best-performing model. The achieved accuracies underscore the effectiveness of these ML techniques in disease prediction and underscore the potential for improving patient outcomes. Beyond the technical aspects, we explore the broader implications of value-based treatment and the integration of ML for various healthcare stakeholders. By emphasizing the numerous benefits of personalized and proactive medical care, our findings illustrate the substantial potential of ML-driven predictive healthcare models to revolutionize traditional healthcare systems. The adoption of ML in healthcare lays the foundation for a more efficient, effective, and patient-centered medical ecosystem, supporting the sustainability and adaptability of healthcare systems in the face of expanding patient populations and complex medical needs. This article significantly contributes to the field by providing comprehensive insights into the experimental stages, showcasing the achieved results, and highlighting the key conclusions derived from our study. By addressing the limitations of the previous abstract, we ensure a more informative and substantial overview of our research, offering valuable knowledge for researchers, practitioners, and decision-makers striving to leverage the power of ML in healthcare innovation.
SOSYO-KÜLTÜREL DEĞİŞME BAĞLAMINDA TUNCELİ ALEVİ OCAKLARINDA AİLE
Authors: Baykan Pınar , Önder Erol Pelin
Published: February 2024

Tunceli’de var olan ve halen aktif biçimde devam eden yedi ana Alevi ocağının aile yapısına odaklanan bu çalışmanın amacı, yedi ocağa mensup Alevi dedeleri ve aile üyelerinin aile yapılarını anlama, aile kurumunun ocaklarda ne gibi karşılıklar bulduğunu öğrenme ve böylece toplumsal değişim sürecinde ailede ne gibi bir farklılaşmanın olduğunu gün yüzüne çıkartmaktır. Alan araştırması dâhilinde Alevi dedeleri ve aile üyeleri ile mülakatlar yapılmıştır. Veriler, içerik analizi tekniğine tabi tutularak çözümlenmiştir. Katılımcılarla yapılan görüşmelerden edilen bulgular hem Alevi dedeleri hem de aile üyelerinin, gerek bulundukları coğrafyada yaşayan Alevi toplumunun gerekse genel olarak tüm Alevi toplumunun aile yapılarının değişime uğradığına işaret etmektedir. Bu değişimi Alevi dedeleri, eskisi gibi Alevi inancına olan bağlılığın kalmadığına ve kentlere olan yoğun göçle birlikte Alevilikte uygulanan ritüellerde, gelenek ve göreneklerde çözülmelerin olmasına bağlarken, aile üyeleri bu durumu genç kuşağın değişime çabuk adapte olmasına, zamanın ve mekânın gerekliliklerine ayak uydurabilmesine bağlamışlardır. Toplumsal değişme ile birlikte kendine has aile yapısına sahip olan Alevi toplumun farklı kültürlerle iç içe girerek Alevi ailesinin bu değişimden etkilendiğini ve bu bağlamda değişim ve dönüşümlere direnç göstermedikleri bulgusuna varılmıştır.
Antibacterial Effect of Basil (Ocimum basilicum) and Table Salt as Alternative Disinfectants against Staphylococcus aureus
Authors:   University Science High School, Central Luzon State University, Science City of Muñoz, Nueva Ecija 3120 Philippines, Garcia Norielle Gearem G. , Daigdigan Vin Danielle R. ,   University Science High School, Central Luzon State University, Science City of Muñoz, Nueva Ecija 3120 Philippines, Landingin Excel John P. ,   University Science High School, Central Luzon State University, Science City of Muñoz, Nueva Ecija 3120 Philippines, Garcia Gemerlyn G. ,   College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz, Nueva Ecija 3120 Philippines, Natividad Lexter R. ,   University Science High School, Central Luzon State University, Science City of Muñoz, Nueva Ecija 3120 Philippines
Published: February 2024

This study was undertaken to evaluate the potency of basil (Ocimum basilicum) extract and table salt as alternative disinfectants based on their effect in inhibiting bacterial proliferation. A sample of bacteria (Staphylococcus aureus) with an initial mean density of 1.35 x 103 CFU/mL was used as the bacterial test culture. Treatments included basil extract (T1), table salt (T2), ethanol (T3, positive control) and distilled water (T4, negative control). The antibacterial effect of the treatments was evaluated in terms of the measurement of the zones of inhibition which was further validated by monitoring the mean recovery counts of bacteria post-application with the treatments given at different concentrations (100, 50, 25 and 10%). The results showed that the larger diameter of the zones of inhibition (with mean measurements that ranged from 17.65 to 20.98 mm) was related to the application of basil extract, table salt and ethanol applied at 100% concentration compared with the 50% (mean measurements ranged from 14.03 to 17.67 mm) underscoring the minimum inhibitory concentration of the candidate disinfectants at 50%. There was a comparable significant reduction of bacterial recovery counts associated with the application of basil extract and ethanol only at 3 h that were not sustained until 6 h. The results indicated that basil extract and table salt at the prescribed concentrations could be used and therefore recommended as disinfectants.
Structural Analysis of Lignins and Hemicelluloses in Mature Bamboo Phyllostachys Bambusoides Culms for Comparison with Immature Bamboo and Other Grass Species
Authors: Okahisa-Kobayashi Yoko
Published: February 2024

An in-depth structural analysis of lignins, hemicelluloses and associated ferulic acid (FA) and p-coumaric acid (CA) in Phyllostachys bambusoides bamboo 2-year old culms and immature 150 cm-long culms were performed. This analysis was comparatively carried out with maize stems and wheat straw, selected as representatives of C4 and C3 grass species. Neutral sugar composition and CA/FA ratio were changed between the immature basal side and immature apical side as well as immature and mature bamboo. As compared to maize or wheat samples, this investigation revealed some original features of the native lignins from mature Phyllostachys bambusoides culms.

Keywords: Bamboo, Monosaccharide sugar composition, Lignins, S/G ratio, p-Coumaric acid (CA), Ferulic acid (FA), p-Coumaroylated Arabinose, Feruloylated Arabinose, Py-GC-MS, FTIR, GC-MS, HPLC
Comparative Study of H-ZSM 5 Zeolite and Graphite Nanofiber (GNF) in Catalytic Pyrolysis of Oil Palm Fronds (OPF)
Authors: Kin Wai Cheah , Yusup Suzana , Muda Nur Suriawanie , Abdul Kapor Nazratul Zaheera
Published: February 2024

In keeping an eye on the goal of a sustainable chemical and energy industry, bio-oil produced from biomass fast pyrolysis liquefaction has aroused great interests and attentions among various stakeholders. In present paper, carbon based catalyst, Graphite Nanofiber (GNF) was employed to investigate and evaluate its potential in thermal pyrolysis of Oil Palm Frond (OPF). The pyrolysis was carried out in a semi batch reactor which was externally heated by an electrical vertical split tube furnace. 15g of OFP biomass with 1.5g of catalysts is thermally decomposed at two distinct temperatures of 573K and 773K, producing a solid char residue and a liquefied vapour product after passing through a condenser. Comparative study of both catalyst performances in thermal pyrolysis of OPF was conducted in term of selectivity and conversion. Between Zeolite ZSM-5 and GNF, GNF catalysts achieved a better conversion performance in transforming a total of 66.57 wt% and 72.40 wt% of biomass into vapour and liquid products at 573K and 773K respectively. On the other hand, H-ZSM 5 Zeolite catalyst yields the highest selectivity of 64.33 wt% toward condensable vapour components at 773K with a remarkably high bio-oil yield of 45.71 wt%. Such superior results strengthened the fact of H-ZSM 5 Zeolite catalysts being the more effective catalyst than GNF in catalytic pyrolysis of OPF.

Keywords: Catalytic Pyrolysis, Oil Palm Fronds, Bio-Oil, Graphite Nanofiber, H-ZSM 5 Zeolite
Nanofiltration of Xylitol Mixed Solution Using Polyethersulfone Membrane in Presence of Silicon Dioxide Nanoparticles or Pluronic F127 Additives: A Comparative Study
Authors: A. Faneer Khalefa , Rohani Rosiah , Mohammad Abdul Wahab
Published: February 2024

Xylitol is a valuable product in medicine and food fields and can be produced mainly by two processes: (1) chemically with catalyst and (2) bio technologically with yeast, fungi or bacteria. This xylitol is commonly present in mixture form which consist of xylitol, xylose and arabinose. Thus purification is required to increase its value either by crystallization, adsorption or membrane technology. The aim of this work is to investigate the influence of using different nanofiltration (NF) membranes to achieve high purity of xylitol from model solution. In order to achieve a desirable purity of xylitol, in-house synthesized NF membranes from pure PES, PES/SiO2 and PES/Pluronic f127 were used in this study. These NF membranes were fabricated via phase inversion method and further characterized to investigate their performances suitable for xylitol purification. To achieve that: a contact angle was used for hydrophilicity, pure water flux (PWF), xylitol permeation and rejection were investigated for the best membrane performances. The contact angle results for these three membranes showed that the SiO2 nanoparticles (NPs) have the best effect on hydrophilicity, moreover, the PWF enhanced and the PES/ Pluronic showed the higher water flux. The highest rejection was accomplished with single PES membrane.

Keywords: Xylitol, nanofiltration, PES, Pluronic, SiO2 NPs.
Autoflocculation of Scenedesmus Quadricauda: Effects of Aeration Rate, Aeration Gas CO2 Concentration and Medium Nitrogen Concentration
Authors: Nguyen Thanh Tien , Uemura Yoshimitsu , Krishnan Vijendren , Abdul Khalid Nadila
Published: February 2024

After microalgal cultivation step, a recent method to harvest microalgae is adding flocculant into microalgal liquid culture to cause flocculation. Flocculated cells are easy to concentrate since their sedimentation time and successive filtering time are expected to be shorter. In this sense, autoflocculation of microalgae may be a beneficial phenomenon for easing the harvesting process of microalgae. In this study, autoflocculation was investigated for the growth of Scenedesmus quadricauda, a type of fresh water microalgae, at 25 ºC in a 5-L column photobioreactor. The BG11 medium was used. The effects of aeration rate, CO2 concentration in aeration gas and nitrogen concentration in culture medium on auto flocculating behavior were investigated. Higher aeration rate, higher CO2 concentration and higher nitrogen concentration caused more flocculation. In other words, autoflocculation became prominent at the condition range where the final cell biomass concentration was lower, in general.

Keywords: Autoflocculation, Scenedesmus quadricauda, aeration rate, aeration gas CO2 concentration, medium nitrogen concentration
Love, Dating, dan Sex berdasarkan Perspektif Iman Kristiani: Pembinaan bagi Siswa-Siswi di SMP Negeri 12 Batam
Authors: Zega Yunardi Kristian , Sabar Hutagalung  , Eben Saluran Halawa  , Job Sinaga  , Novalita Tampubolon  , Firiska Yulinata  , Ernawaty Simanjuntak  , Desy Doreni Napitupulu  , Winda Sari Rumahorbo
Published: February 2024

Masa remaja sering kali diwarnai dengan pergaulan yang belum matang dan kecenderungan untuk menjalin hubungan romantis. Hal ini dapat mengarah pada perilaku tidak sehat, termasuk keterlibatan dalam aktivitas seksual di usia yang belum tepat. Kurangnya pemahaman tentang pentingnya menjaga hubungan dengan Tuhan dan kekudusan hidup juga dapat memperburuk situasi ini. Oleh sebab itu, tim Pengabdian kepada Masyarakat (PkM) STT Real Batam, bertujuan untuk memberikan pengetahuan dan kesadaran bagi peserta didik di SMP Negeri 12 Batam tentang pentingnya menjaga hubungan dengan Tuhan serta menjalani kehidupan yang kudus. Kegiatan PKM ini melibatkan seminar, lokakarya, dan diskusi. Materi yang disampaikan mencakup nilai-nilai agama, etika dalam hubungan interpersonal, dan pemahaman tentang pentingnya menunda aktivitas seksual hingga dalam konteks yang tepat. Hasil kegiatan PKM ini menunjukkan peningkatan signifikan dalam pemahaman peserta didik tentang pentingnya menjaga hubungan dengan Tuhan dan kekudusan hidup. Peserta didik di SMP Negeri 12 Batam juga memperoleh pengetahuan yang lebih baik tentang risiko dan dampak negatif dari hubungan yang tidak sehat. Selain itu, terjadi perubahan positif dalam sikap dan perilaku peserta didik terkait dengan hubungan romantis dan aktivitas seksual, yang menunjukkan adanya pengaruh yang positif dari kegiatan PKM ini dalam membina hal berpacaran di masa remaja.
Information Security Management Systems - Evolving Landscape & ISO 27001: An Empirical Study
Authors: Makhija Anil K.
Published: February 2024

ABSTRACT In order to strengthen the partnership both economically and politically among countries in the region, the Belt and Road Initiative (BRI) was introduced and implemented since 2013 by the People Republic of China. Information technology has become an integral part of all business activities. Managing information security has been a key aspect in ensuring that increased information security risks (due to reliance on IT) are managed effectively. The reliance on digital and technology platforms has increased even further due to pandemic driven changes. This has led to higher information security risk exposure of organizations and their employees and their customers. Organizations use various frameworks to design and implement information security management systems, with ISO 27001 standard being the leading framework. Past researches in ISMS and leveraging ISO 27001 have had limitation of single country focus, Further there is limited research on relevance of ISO 27001 in evolving paradigm of computing shift. This global research presents an empirical study, based on inputs from industry practitioners, reflecting the key drivers for ISO 27001 implementation and certification, investigates pattern in those drivers based on size of the organization and examines the relevance of ISO 27001 both as framework and / or certification in the evolving scenario of cloud. Findings of the research indicate that the top reason for ISO 27001 implementation and certification is “compliance”, followed by “business value”, “competitive edge”, and “breach reduction” in that order. Findings also indicate that focus on information security is increasing and ISO 27001 implementation provides an effective ISMS and ISO 27001 certification helps organizations in improving their trustworthiness in keeping information secure. Keywords: Information system, security, management system, information technology
English Students' Perception on the Use of Edlink Platform during Covid-19 Pandemic at University
Authors: Luxviya Iffa , Abbas M. Fadhly Farhy
Published: February 2024

Online learning is any learning that uses the internet or web-based. Online learning can be done by using learning applications, one of which is the Edlink platform. This research aims at explaining the perception of English education students on the use of Edlink platform during covid-19 pandemic. This research used descriptive-quantitative research methods. The population of the research was the first, third, and fifth semester student in English department in Universitas Lancang Kuning. The researchers selected a sample of 45 students from the population. In the data collection, researchers used questionnaires. Before being handed out the questionnaire tested its validity and reliability values using Correlation Product Moment in SPSS 17.0. There is a questionnaire of 22 statements that valid because of sig results. (2-tailed)]< significant level (Î±) 0,05. With cronbach-alpha >970 the result showed that students' perception of the use of the Edlink platform during the covid-19 pandemic that the majority of English education students have a positive and categorized into high perception of the use of the Edlink platform application. Before this application is used students are given socialization and application coordinators to deal with the obstacles experienced. In conclusion students can adapt the Edlink platform to temporarily replace learning during covid-19.
Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study
Authors: Tajrin Andi , Ruslin M. , Rasul Muh. Irfan , Nurwahida  , Hadira  , Mubarak Husni , Oginawati Katharina , Fahimah Nurul , Tanziha Ikeu , Damayanti Annisa Dwi , Mukhaiyar Utriweni , Arumsari Asri , Astuti Ida Ayu , Putri Farah Asnely , Silvia Shinta
Published: February 2024

Background: The pathogenesis of orofacial cleft (OFC) is multifactorial, involving both genetic and non-genetic factors, the latter of which play a key role in the development of these anomalies. This paper addresses the incidence of OFC in Indonesia, with a focus on identifying and examining the distribution of contributory factors, including parental medical history, pregnancy history, and environmental influences.Methods: The study was conducted through the collection of primary data. An interdisciplinary research team from Indonesia administered a standardized questionnaire to parents who had children with OFC and who had provided informed consent. The case group comprised 133 children born with cleft lip and/or palate, and the control was 133 noncleft children born full-term. The risk factors associated with OFC anomalies were analyzed using the chi-square test and logistic regression. All statistical analyses were performed using SPSS version 25. A p-value of 0.05 or less was considered to indicate statistical significance.Results: The study comprised 138 children, of whom 82 were boys (59.4%) and 56 were girls (40.6%). Among them, 45 patients (32.6%) presented with both cleft lip and cleft palate, 25 individuals (18.1%) had a cleft palate only, and 28 patients (20.3%) had a cleft lip only. OFC was found to be significantly associated with a maternal family history of congenital birth defects (p< 0.05), complications during the first trimester (p< 0.05), consumption of local fish (p< 0.05), caffeine intake (p< 0.05), prolonged medication use (p< 0.05), immunization history (p< 0.05), passive smoking (p< 0.05), and X-ray exposure during pregnancy (p< 0.05).Conclusion: The findings indicate close relationships between the incidence of OFC and maternal medical history, prenatal factors, and environmental influences.
INTEGRATION OF NANOTECHNOLOGY AND HERBAL MEDICINE: THERAPEUTIC POTENTIAL FOR IMPROVEMENT OF HEALTH CARE
Authors: Bojanić Anđela , Suručić Relja , Đermanović Mirjana
Published: February 2024

Herbal medicine represents one of the oldest forms of medical practice since ancient times, which is still used around the world and includes the use of herbal medicines for preventive or therapeutic purposes. On the other hand, nanomedicine represents a new scientific field that uses nanotechnology, the manipulation of materials on the nanoscale (1 - 100 nm), for the diagnosis, treatment and prevention of diseases at the molecular level. Although these two disciplines are very different at first glance, their integration could unlock the full therapeutic potential of phytotherapy by enabling innovative approaches to improve the bioavailability and efficacy of herbal medicines through targeted and controlled delivery, allowing to overcome its current limitations and reduce side effects. This paper explores the importance of implementing nanotechnology in herbal medicine, emphasizing its potential impact on health care. Also, the techniques of encapsulating herbal medicines into nanomedicines, various herbal nanoformulations and application and modes of action, are presented. In conclusion, continued research in this area .Is considered a key factor in unlocking the full potential of nanomedicine application in herbal medicine. Such research drives innovation, as well as personalized approaches to therapy and advances healthcare, which could pave the way for a healthier and more sustainable future.
BIOMEDICAL ENGINEERING AND ADDITIVE MANUFACTURING
Authors: Golubović Zorana , Petrov Ljubiša , Bojović Božica
Published: February 2024

Additive manufacturing (AM) technologies have evolved significantly in recent decades, bring- ing new trends to production processes. The advantages compared to conventional technologies are numer- ous: production is simpler and faster, geometry can be adjusted more easily, the quality of finished parts is better, less material is wasted, and costs are lower. Because of the wide range of possibilities, the different AM processes and the materials that can be used, these technologies have found their place in many indus- tries, not least in biomedical applications. Flexibility in geometric freedom, in particular, is important for the fabrication of biomedical devices. It is already known that AM technologies can improve and facilitate diagnostics through the fabrication of customized and in-demand parts, support consultation between phy- sicians and patients, and thus provide the opportunity to develop individualized, patient-specific medicine. This review briefly outlines current applications and AM techniques present in the biomedical field.
Anti-scattering signal processing method of VMD-ICA based underwater lidar
Authors: Li Chao-Feng , Wang Zhen , Liu Xin-Yu , Yang Su-Hui , Xu Zhen , Fan Chao-Yang ,   School of Optics Photonics, Beijing Institute of Technology, Beijing 100081, China,   34th Research Institute of China Electronics Technology Corporation, Guilin 541000, China
Published: February 2024

This paper proposes an underwater signal processing method based on the combination of variational mode decomposition (VMD) and independent component analysis (ICA). In this method, the VMD is used to decompose a set of echo signals into groups of eigenmodal signals arranged according to the order of their frequencies. These modal signals are then used as an observation matrix for ICA to ensure the integrity of the separated target echo signals. In this method, the correlation between the decomposed modal signals and the original signal is used to select the signals which are used as input matrix rows for ICA. The signal-to-clutter ratio is used to determine the number of decomposed layers. The ICA is used to separate the scattering and target echoes, so as to recover the weak target echoes in the strongly scattered water and greatly improve the ranging accuracy. A 532 nm intensity-modulated continuous wave (CW) laser is used in the underwater ranging experiments. The attenuation coefficient of the water is changed by adding Mg(OH)2, ranging experiments are carried out at different attenuation lengths. The experimental results show that the signal processing method can be used to successfully measure the target within 9 AL (attenuation length) when the laser output power is 2.3 W, and the ranging accuracy is improved from 16 cm to less than 5 cm by using the algorithm. The proposed method can be applied to underwater lidar application in turbid water and long distance ranging underwater where the scattering dominates the echoes.
Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability
Authors: Duveau Fabien , Cordier Céline , Chiron Lionel , LeBec Matthias , Pouzet Sylvain , Séguin Julie , Llamosi Artémis , Sorre B. , Meglio Jean-Marc Di , Hersen Pascal
Published: February 2024

Natural environments of living organisms are often dynamic and multifactorial, with multiple parameters fluctuating over time. To better understand how cells respond to dynamically interacting factors, we quantified the effects of dual fluctuations of osmotic stress and glucose deprivation on yeast cells using microfluidics and time-lapse microscopy. Strikingly, we observed that cell proliferation, survival and signaling depend on the phasing of the two periodic stresses. Cells divided faster, survived longer and showed decreased transcriptional response when fluctuations of hyperosmotic stress and glucose deprivation occurred in phase than when the two stresses occurred alternatively. Therefore, glucose availability regulates yeast responses to dynamic osmotic stress, showcasing the key role of metabolic fluctuations in cellular responses to dynamic stress. We also found that mutants with impaired osmotic stress response were better adapted to alternating stresses than wild-type cells, showing that genetic mechanisms of adaptation to a persistent stress factor can be detrimental under dynamically interacting conditions.
Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles
Authors: Xie Jing , Xu Yafei , Liu Xuhua , Long Li , Chen Ji , Huang Chunyan , Shao Yan , Cai Zhiqing , Zhang Zhimin , Zhou Ruixin , Leng Jiarong , Bai Xiaochun , Song Qiancheng
Published: February 2024

Although preclinical and clinical studies have shown that exercise can inhibit bone metastasis progression, the mechanism remains poorly understood. Here, we found that non-small cell lung cancer (NSCLC) cells adjacent to bone tissue had a much lower proliferative capacity than the surrounding tumor cells. Subsequently, it was demonstrated that osteocytes, sensing mechanical stimulation generated by exercise, inhibit NSCLC cell proliferation and sustain the dormancy thereof by releasing small extracellular vesicles with tumor suppressor microRNAs, such as miR-99b-3p. Furthermore, mechanical loading of the tibia inhibited the bone metastasis progression of NSCLC. Notably, bone metastasis progression of NSCLC was inhibited by moderate exercise, and combinations with zoledronic acid had additive effects. Moreover, exercise preconditioning effectively suppressed bone metastasis progression. This study significantly advances the understanding of the mechanism underlying exercise-afforded protection against bone metastasis progression.
Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies
Authors: Lu Xiuyuan , Hayashi Hiroki , Ishikawa Eri , Takeuchi Yukiko , Dychiao Julian Vincent Tabora , Nakagami Hironori , Yamasaki Sho
Published: February 2024

SARS-CoV-2 vaccines have been used worldwide to combat COVID-19 pandemic. To elucidate the factors that determine the longevity of spike (S)-specific antibodies, we traced the characteristics of S-specific T cell clonotypes together with their epitopes and anti-S antibody titers before and after BNT162b2 vaccination over time. T cell receptor (TCR) αβ sequences and mRNA expression of the S-responded T cells were investigated using single-cell TCR- and RNA-sequencing. Highly expanded 199 TCR clonotypes upon stimulation with S peptide pools were reconstituted into a reporter T cell line for the determination of epitopes and restricting HLAs. Among them, we could determine 78 S epitopes, most of which were conserved in variants of concern (VOCs). In donors exhibiting sustained anti-S antibody titers (designated as “sustainers”), S-reactive T cell clonotypes detected immediately after 2nd vaccination polarized to follicular helper T (Tfh)-like cells, which was less obvious in “decliners”. Even before vaccination, S-reactive CD4
+
T cell clonotypes did exist, most of which cross-reacted with environmental or symbiotic bacteria. However, these clonotypes contracted after vaccination. Conversely, S-reactive clonotypes dominated after vaccination were undetectable in pre-vaccinated T cell pool, suggesting that highly-responding S-reactive T cells were established by vaccination from rare clonotypes. These results suggest that
de novo
acquisition of memory Tfh-like cells upon vaccination contributes to the longevity of anti-S antibody titers.
Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
Authors: Oevel Kristine , Hohensee Svea , Kumar Atul , Rosas-Brugada Irving , Bartolini Francesca , Soykan Tolga , Haucke Volker
Published: February 2024

Neurotransmission at synapses is mediated by the fusion and subsequent endocytosis of synaptic vesicle membranes. Actin has been suggested to be required for presynaptic endocytosis but the mechanisms that control actin polymerization and its mode of action within presynaptic nerve terminals remain poorly understood. We combine optical recordings of presynaptic membrane dynamics and ultrastructural analysis with genetic and pharmacological manipulations to demonstrate that presynaptic endocytosis is controlled by actin regulatory diaphanous-related formins mDia1/3 and Rho family GTPase signaling. We show that impaired presynaptic actin assembly in the near absence of mDia1/3 and reduced RhoA activity is partly compensated by hyperactivation of Rac1. Inhibition of Rac1 signaling further aggravates impaired presynaptic endocytosis elicited by loss of mDia1/3. Our data suggest that interdependent mDia1/3-Rho and Rac1 signaling pathways cooperatively act to facilitate synaptic vesicle endocytosis by controlling presynaptic F-actin.
Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo
Authors: Ichimura Taro , Kakizuka Taishi , Sato Yuki , Itano Keiko , Seiriki Kaoru , Hashimoto Hitoshi , Itoga Hiroya , Onami Shuichi , Nagai Takeharu
Published: February 2024

We established a volumetric trans-scale imaging system with an ultra-large field-of-view (FOV) that enables simultaneous observation of millions of cellular dynamics in centimeter-wide three-dimensional (3D) tissues and embryos. Using a custom-made giant lens system with a magnification of 2× and a numerical aperture (NA) of 0.25, and a CMOS camera with more than 100 megapixels, we built a trans-scale scope AMATERAS-2, and realized fluorescence imaging with a lateral spatial resolution of approximately 1.2 µm across an FOV of approximately 1.5 × 1.0 cm
2
. The 3D resolving capability was realized through a combination of optical and computational sectioning techniques tailored for our low-power imaging system. We applied the imaging technique to 1.2 cm-wide section of mouse brain, and successfully observed various regions of the brain with sub-cellular resolution in a single FOV. We also performed time-lapse imaging of a 1-cm-wide vascular network during quail embryo development for over 24 hours, visualizing the movement of over 4.0 × 10
5
vascular endothelial cells and quantitatively analyzing their dynamics. Our results demonstrate the potential of this technique in accelerating production of comprehensive reference maps of all cells in organisms and tissues, which contributes to understanding developmental processes, brain functions, and pathogenesis of disease, as well as high-throughput quality check of tissues used for transplantation medicine.
Enhancing Bone Regeneration and Osseointegration using rhPTH(1-34) and Dimeric R25CPTH(1-34) in an Osteoporotic Beagle Model
Authors: Shin Jeong-Oh , Lee Jong-Bin , Lee Sihoon , Kim Jin-Woo
Published: February 2024

Despite continuous parathyroid hormone (PTH) exposure potentially accelerating bone resorption, intermittent PTH administration has shown anabolic effects on bone microarchitecture. This study investigates the therapeutic impacts of two PTH analogs, rhPTH(1-34) and dimeric
R25C
PTH(1-34) on bone regeneration and osseointegration in a postmenopausal osteoporosis animal model.Twelve female beagles, osteoporotic post-ovariectomy, underwent implant surgeries. Animals were divided into three groups: control, daily rhPTH(1-34) injection, and daily dimeric
R25C
PTH(1-34) injection. After 10 weeks, bone regeneration and implant osseointegration were evaluated using micro-CT, histological/histomorphometric analyses, and serum biochemical analysis.While the rhPTH(1-34) group demonstrated improved microarchitectural characteristics, such as BMD, BV, trabecular metrics, and osseointegration degree, the dimeric
R25C
PTH(1-34) group showed similarly enhanced anabolic effects around the titanium implants, albeit these were less pronounced than the rhPTH(1-34), yet significantly better than the control group. Histologic and TRAP analyses revealed that both PTH analogs significantly promoted bone regeneration and remodeling, especially in artificially created bone defects.This study demonstrated the therapeutic effects of rhPTH(1-34) and dimeric
R25C
PTH(1-34) on bone regeneration and titanium osseointegration in a beagle model with osteoporosis.
The asymmetric transfers of visual perceptual learning determined by the stability of geometrical invariants
Authors: Yang Yan , Zhuo Yan , Zuo Zhentao , Zhuo Tiangang , Chen Lin
Published: February 2024

We could recognize the dynamic world quickly and accurately benefiting from extracting invariance from highly variable scenes, and this process can be continuously optimized through visual perceptual learning. It is widely accepted that more stable invariants are prior to be perceived in the visual system. But how the structural stability of invariants affects the process of perceptual learning remains largely unknown. We designed three geometrical invariants with varying levels of stability for perceptual learning: projective (e.g., collinearity), affine (e.g., parallelism), and Euclidean (e.g., orientation) invariants, following the Klein’s Erlangen program. We found that the learning effects of low-stability invariants could transfer to those with higher stability, but not vice versa. To uncover the mechanism of the asymmetric transfers, we used deep neural networks to simulate the learning procedure and further discovered that more stable invariants were learned faster. Additionally, the analysis of the network’s weight changes across layers revealed that training on less stable invariants induced more changes in lower layers. These findings suggest that the process of perceptual learning in extracting different invariants is consistent with the Klein hierarchy of geometries and the relative stability of the invariants plays a crucial role in the mode of learning and generalization.
Vegetative cell wall protein OsGP1 regulates cell wall mediated soda saline-alkali stress in rice
Authors: Zhu Fengjin , Cheng Huihui , Guo Jianan , Bai Shuomeng , Liu Ziang , Huang Chunxi , Shen Jiayi , Wang Kai , Yang Chengjun , Guan Qingjie
Published: February 2024

Plant growth and development are inhibited by the high levels of ions and pH due to soda saline-alkali soil, and the cell wall serves as a crucial barrier against external stresses in plant cells. Proteins in the cell wall play important roles in plant cell growth, morphogenesis, pathogen infection and environmental response. In the current study, the full-length coding sequence of the vegetative cell wall protein gene OsGP1 was characterized from Lj11 (Oryza sativa longjing11), it contained 660 bp nucleotides encoding 219 amino acids. Protein-protein interaction network analysis revealed possible interaction between CESA1, TUBB8, and OsJ_01535 proteins, which are related to plant growth and cell wall synthesis. OsGP1 was found to be localized in the cell membrane and cell wall. Furthermore, overexpression of OsGP1 leads to increase in plant height and fresh weight, showing enhanced resistance to saline-alkali stress. The ROS (reactive oxygen species) scavengers were regulated by OsGP1 protein, peroxidase and superoxide dismutase activities were significantly higher, while malondialdehyde was lower in the overexpression line under stress. These results suggest that OsGP1 improves saline-alkali stress tolerance of rice possibly through cell wall-mediated intracellular environmental homeostasis.