bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Influencing Cyst Infection in Autosomal Dominant Polycystic Kidney Disease
Authors: Suwabe Tatsuya , Ubara Yoshifumi , Hayami Noriko , Yamanouchi Masayuki , Hiramatsu Rikako , Sumida Keiichi , Sawa Naoki , Sekine Akinari , Kawada Masahiro , Hasegawa Eiko , Hoshino Junichi , Takaichi Kenmei
Published: December 2018

Background: Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death due to cyst infection. Methods: All ADPKD patients undergoing cyst drainage or nephrectomy or partial hepatectomy at Toranomon Hospital from January 2004 to March 2016, in whom cyst fluid analysis showed bacteria or neutrophils indicating definite cyst infection, were reviewed retrospectively. Factors influencing the duration of hospitalization and death due to cyst infection were analyzed. Results: A total of 243 patients with cyst infection were enrolled, including 104 men and 139 women (mean age: 62.6 ± 10.0 years). Seventeen patients died of cyst infection. Multivariate logistic regression analysis revealed that hepatomegaly, positive cyst contents culture, and the maximum white blood cell (WBC) count were significantly associated with death from cyst infection. Death was significantly more likely if patients had massive hepatomegaly (≥5,113.2 mL) compared with mild hepatomegaly (< 1,898.7 mL; odds ratio 38.1; 95% CI 2.9–492.6, p = 0.0004). Multivariate Cox proportional hazards analysis revealed that older age, dialysis duration, hepatic transcatheter arterial embolization, maximum WBC count, and hepatomegaly were significantly associated with longer hospital stay for cyst infection, while female sex, nephrectomy, serum albumin, and serum cholinesterase were significantly associated with shorter hospital stay. Discharge alive from hospital was significantly associated with massive hepatomegaly versus mild hepatomegaly (hazard ratio 0.0072; 95% CI 0.0008–0.0659, p < 0.0001). Conclusions: Hepatomegaly was strongly associated with both death and longer hospital stay due to cyst infection.
Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons
Authors: Bartos Ales , Fayette Dan
Published: December 2018

Background: The Czech version of the Montreal Cognitive Assessment (MoCA-CZ) and delayed recall of 5 words have not been validated in patients with mild cognitive impairment (MCI) due to Alzheimer disease (AD) and compared to norms of a large population. Method: The MoCA-CZ was administered to 1,600 elderly individuals in 2 groups consisting of 48 patients with MCI due to AD (AD-MCI) and 1,552 normal elderly adults. Results: MoCA-CZ scores were significantly lower in the AD-MCI patients than in the normal elderly (21 ± 4 vs. 26 ± 3 points; p = 0.03). Under the recommended cutoff score of ≤25, the MoCA-CZ demonstrated an excellent sensitivity of 94% but a low specificity of 62%. When the score was reduced to ≤24, the MoCA-CZ showed an optimal sensitivity of 87% for AD-MCI and a specificity of 72%. Normal elderly persons should recall at least 2 words after delay (sensitivity 80%, specificity 74%). Several cutoff points were derived from normative data stratified by age and education. Conclusions: The cutoff for AD-MCI and stratified norms are available for the MoCA total score and delayed recall of the Czech version. The cut-off scores of the MoCA-CZ, sensitivity, and specificity are lower than in the original study.
miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4
Authors: Yang Lei , Ge Dawei , Chen Xi , Jiang Chunzhi , Zheng Shengnai
Published: December 2018

Background/Aims: To explore the potential role of miR-544a in spinal cord injury and the possible mechanism involved. Methods: We established a mouse model with spinal cord injury to examine the changes in grip force recovery of the forelimb or the posterior limb of the mouse. Microarray was performed to achieve differentiated miRNAs in the mice. The expressions of miR-544a, MCP-1, IL36B and IL17B after spinal cord injury were detected by qRT-PCR. Subsequently, miR-544a was overexpressed to observe changes in inflammation and grip strength after spinal cord injury. Target gene of miR-544a was then predicted using bioinformatics technology. Finally, dual luciferase reporter gene assay was used to verify the binding of miR-544a to its target gene. Results: Using mice models with spinal cord injury, we found that the strength of their four limbs began to recover 7 days after injury. The results of microarray and qRT-PCR confirmed that mir-544a level in mice with spinal cord injury decreased with increase of injury time, while the levels of inflammatory genes MCP-1 (monocyte chemoattractant protein-1), IL1 (interleukin-1) and TNF-α (tumor necrosis factor alpha) IL36B (interleukin-36 beta) and IL17B (interleukin-17 beta) were significantly increased. However, overexpression of miR-544a in the mice significantly reduced the level of inflammation and restored their grip strength in their four limbs. Finally, we found that miR-544a can bind to the NEUROD4 (Neurogenic differentiation 4) 3’UTR (Untranslated Region) region through bioinformatics website prediction, which was further confirmed by dual luciferase reporter assay. NEUROD4 level was significantly reduced following the overexpression of miR-544a. Conclusion: The expression of miR-544a was significantly decreased after spinal cord injury. High expression of miR-544a could alleviate the inflammation caused by spinal cord injury and promote the recovery of spinal cord via the inhibition of NEUROD4.
Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging and Catheter Ablation of Atrial Fibrillation: 5‐Year Follow‐Up Data
Authors: Chelu Mihail G. , King Jordan B. , Kholmovski Eugene G. , Ma Junjie , Gal Pim , Marashly Qussay , AlJuaid Mossab A. , Kaur Gagandeep , Silver Michelle A. , Johnson Kara A. , Suksaranjit Promporn , Wilson Brent D. , Han Frederick T. , Elvan Arif , Marrouche Nassir F.
Published: December 2018

Background

Late gadolinium enhancement magnetic resonance imaging is an effective tool for assessment of atrial fibrosis. The degree of left atrial fibrosis is a good predictor of atrial fibrillation (
AF
) ablation success at 1 year, but the association between left atrial fibrosis and long‐term ablation success has not been studied.

Methods and Results

Late gadolinium enhancement magnetic resonance images of sufficient quality to quantify atrial fibrosis were obtained before the first
AF
ablation in 308 consecutive patients. Left atrial fibrosis was classified in 4 Utah stages (I, 0–10%;
II
, 10–20%;
III
, 20–30%; and
IV
, >30%). Patients were followed up for up to 5 years until the time of first arrhythmia recurrence or second ablation. A total of 308 patients were included; the mean age was 64.5±12.1 years, and 63.4% were men. During follow‐up, 157 patients experienced an arrhythmia recurrence and 106 patients underwent a repeated ablation. A graded effect was observed in which patients with more advanced atrial fibrosis were more likely to experience recurrent
AF
(hazard ratio for stage
IV
versus stage I, 2.73; 95% confidence interval, 1.57–4.75) and undergo a repeated ablation (proportional odds ratio for stage
IV
versus stage I, 5.19; 95% confidence interval, 2.12–12.69).

Conclusions

The degree of left atrial fibrosis predicts the success of
AF
ablation at up to 5 years follow‐up. In patients with advanced atrial fibrosis,
AF
ablation is associated with a high procedural failure rate.
The seven voices of information literacy (IL)
Authors: Cunningham Veronica , Williams Dorothy
Published: December 2018

The purpose of this research was to discover the conceptions of information literacy (IL) prevalent across multiple stakeholder groups in an international middle school community. The research involved students, parents, teachers, librarians, IT personnel, administrators and leadership in recorded focus group discussions. Using a phenomenographic approach the qualitatively different ways that stakeholder groups understood IL were revealed. The study found extensive variation in the ways IL is understood, revealing 27 different conceptions of IL shared to varying degrees across stakeholder groups. The findings add to our knowledge of IL in several ways: several new conceptions of IL surfaced from this more diverse sample and new light was shed on the way that people’s perceptions and experience of their information context influences their thinking about IL. The article fills a gap in the literature on two levels: firstly, by providing a multi-stakeholder perspective on IL offsetting the multitude of single stakeholder IL studies and secondly by focusing on an international middle school environment which has not been a context for IL research in the recent past.
Comics, questions, action!
Authors: Margolin Stephanie , Brown Mason , Ward Sarah
Published: December 2018

In a four-session Summer Bridge programme, we experimented with new curricular and pedagogical ideas with a group of incoming freshmen. We developed the Comics-Questions Curriculum (CQC), which melds students’ question asking with a focus on comics. The purpose of this paper is to describe the rationale for and ongoing development of the CQC as well as the ways the CQC fosters engagement of students and librarians, builds upon students’ existing skills but propels them forward toward college-level work, and positions librarians as partners in students’ college work. Although it was designed for a specific purpose initially, the CQC in its current state is widely adaptable to other contexts beyond the original scope.
When the library steps in
Authors: Yap Joseph Marmol , Ramos Manabat April
Published: December 2018

Media and information literacy (MIL) was recently introduced in the Philippines although it has been the talk of the town since the Grunwald Declaration on media education in 1982. De La Salle University (DLSU) Libraries is an active partner in promoting MIL and decided to support this as part of its information literacy campaign. This project report provides an overview of a seminar-workshop programme on MIL conducted at DLSU Libraries for public school teacher-librarians. The programme is based on a United Nations Educational, Scientific and Cultural Organization (UNESCO) publication entitled ‘Pedagogies of Media and Information Literacies’ which has five modules: Understanding media and information literacy; Young people as global media audiences; Media cultures and technologies; How to interpret media; Cooperation and sharing ideas. The project report acknowledges how the participants were able to grasp and understand the MIL values and how they were able to apply these values in their own workplace. Finally, the report shares analyses of the participants’ reviews of the programme.
Checklist of the Acanthocephala in wildlife vertebrates of Mexico
Authors: GARCÍA-PRIETO LUIS , GARCIA-VARELA MARTÍN , MENDOZA-GARFIAS BERENIT , DE LEÓN GERARDO PÉREZ-PONCE
Published: December 2018

Fifty four named and twenty three undetermined species of acanthocephalans associated with 213 wildlife vertebrate host species from Mexico are listed; they come from 220 localities, pertaining to 28 of the 33 Mexican states. The checklist contains information on their hosts, habitat, distribution, and records. In addition, three species of acanthocephalans (Polymorphus obtusus, Polymorphus trochus, and Southwellina dimorpha), are registered for the first time in Mexico, twenty six new locality records, and ten new host records are presented.
A taxonomic study of the genus Bolivaritettix Günther (Orthoptera: Tetrigidae: Metrodorinae)
Authors: DENG WEI-AN , ZHENG ZHE-MIN , WEI SHI-ZHEN
Published: December 2018

Taxonomy of a tetrigid genus Bolivaritettix Günther is reviewed. Two new species, B. tenuifemura sp. nov. and B. sanbaishanensis sp. nov. are described. An updated identification key to all known species of the genus is given.
Retroactive changes should be introduced in the Code only with great care: problems related to the spellings of nomina
Authors: DUBOIS ALAIN
Published: December 2018

Taxonomy is currently facing a major crisis and is likely to have strong difficulties to reduce significantly the taxonomic gap before the biodiversity crisis has wiped out a large proportion of the living species of the earth. In this context, taxonomists should pay great attention to the nomenclatural Rules, and care for them to help them in this urgent task, rather than diverting their time and energy to secondary or useless questions or debates. A major purpose of the Code is to promote nomenclatural stability in zoology. This requires stability in the Rules, or at least that a great care be taken, when establishing new Rules, to avoid that they can have unexpected deleterious consequences for stability. In particular, in most cases, it is crucial to deny retroactivity to the new Rules. Several examples of problems created in zoological nomenclature by introduction of changes in Articles dealing with the spellings of nomina are examined in detail. These Articles were modified, with retroactive value, in the 1985 edition (Art. 32, 33, 35 and 39) and in the 1999 edition (Art. 24) of the Code. It is shown that these changes, which have no clear “philosophical” or practical justifications and which result in no clear benefits, have in fact had negative impacts on nomenclatural practice. Their implementation requires heavy useless additional work from taxonomists and has negative results in nomenclatural stability that had clearly not been anticipated by the ICZN when promulgating them. In a few sets of nomina tested below, the changes in the 1985 edition resulted in spelling changes for 10.0 to 22.2 % of the nomina, and those in the 1999 edition for 21.7 to 33.3 % of the nomina, roughly a quarter of them on the whole (24.5 %). Among others that are less emblematic, a striking case is that of the fish generic nomen Tetraodon, widely used especially since the genome of a species of this genus has been sequenced, and which should be changed to Tetrodon because of the unwarranted introduction of the new Art. 24.2.4 into the Code. It is suggested that these changes should be cancelled, or at least denied retroactivity from the years of their promulgations. In order to make this discussion easier, a “taxonomy” of the different kinds of spellings of nomina, and a dichotomic key to such situations, are provided. This stresses the fact that detailed discussions on very precise aspects of the functioning of nomenclatural Rules, as well as the computerization of nomenclatural data for online databases, require to use a specialized technical terminology to designate the nomenclatural concepts and tools, not vague “common language” terms like “name” or “type”: “keep the Rules, but change the terms”. The problems outlined here should be kept in mind by the ICZN before implementing drastic changes in the Rules of nomenclatural availability, as recently suggested.
Tropical Cyclone Diurnal Cycle Signals in a Hurricane Nature Run
Authors: Dunion Jason P. , Thorncroft Christopher D. , Nolan David S.
Published: December 2018

The diurnal cycle of tropical convection and tropical cyclones (TCs) has been previously described in observational-, satellite-, and modeling-based studies. The main objective of this work is to expand on these earlier studies by identifying signals of the TC diurnal cycle (TCDC) in a hurricane nature run, characterize their evolution in time and space, and better understand the processes that cause them. Based on previous studies that identified optimal conditions for the TCDC, a select period of the hurricane nature run is examined when the simulated storm was intense, in a low shear environment, and sufficiently far from land. When analyses are constrained by these conditions, marked radially propagating diurnal signals in radiation, thermodynamics, winds, and precipitation that affect a deep layer of the troposphere become evident in the model. These propagating diurnal signals, or TC diurnal pulses, are a distinguishing characteristic of the TCDC and manifest as a surge in upper-level outflow with underlying radially propagating tropical squall-line-like features. The results of this work support previous studies that examined the TCDC using satellite data and have implications for numerical modeling of TCs and furthering our understanding of how the TCDC forms, evolves, and possibly impacts TC structure and intensity.
Providing mental health peer support 1: A Delphi study to develop consensus on the essential components, costs, benefits, barriers and facilitators
Authors: Burke Eilish M , Pyle Melissa , Machin Karen , Morrison Anthony P
Published: December 2018

Background:

While formalised mental health peer support is on the increase, there continues to be a lack of consensus regarding the peer supporter role.

Aim:

The aim was to develop consensus on the essential components, personal costs, personal benefits, barriers and facilitators involved in providing mental health peer support.

Methods:

The Delphi method was used. In the first round, an exhaustive list of statements pertaining to peer support was generated from literature review and consultation with experienced peer supporters. In the second round, 147 UK peer supporters rated statements online or via post, and completed a questionnaire about experiences of providing peer support. Criteria for consensus were applied. Where there was uncertainty, statements were re-rated. Descriptive statistics and group comparisons were calculated. The final statements were grouped thematically.

Results:

Consensus was reached on statements pertaining to essential components ( n = 67), personal benefits ( n = 21), barriers ( n = 1) and facilitators ( n = 35). Formal peer support involves many skills and competencies. Most participants agreed that a wide range of personal benefits come with the role. Organisations may facilitate peer support through their values, actions and oversight. Approximately half of the sample worked in public services and were more likely to have concerns regarding pay and career progression.

Conclusion and Implications for Practice:

Results define the peer supporter role and add to the knowledge base about optimal conditions for it to thrive. Recommendations are made regarding role development and career progression, and future research to better understand personal costs and benefits.
Illness representations about schizophrenia and bipolar disorder held by French people without a mental disorder
Authors: Averous Priscillia , Charbonnier Elodie , Lagouanelle-Simeoni Marie-Claude , Dany Lionel
Published: December 2018

Introduction:

The stigmatization of various mental disorders has been widely studied, but the common understanding of mental disorders has seldom been explored, especially for specific psychiatric disorders such as schizophrenia or bipolar disorder. We used the Common-Sense Model to understand and compare the general public’s multidimensional illness representations for schizophrenia and bipolar disorder.

Methods:

The sample recruited was 1,000 participants who reported no mental disorder, and their public illness representations for schizophrenia ( n = 500) and bipolar disorder ( n = 500) were assessed via an Internet survey using a modified version of the Illness Perception Questionnaire for Schizophrenia.

Results:

Schizophrenia was viewed as more serious, severe, and chronic than bipolar disorder, with a high impact, major consequences, and less effective treatments. Environmental and individual factors were rated higher for bipolar disorder than they were for schizophrenia, while biological functioning items were rated lower.

Conclusion:

Similarities between the public’s illness representations observed in this study and the representations of patients and relatives explored in previous studies confirm that illness representations are essentially guided by social communication and cultural knowledge about the relevant illness. This reinforces the need to improve social communication about mental disorders and more specifically schizophrenia.
The relationship between polygamy and psychiatric disorders in Turkish women
Authors: Yılmaz Ertan , Tamam Lut
Published: December 2018

Backround:

Recent data suggest a reduction in the prevalence of polygamy in the southeastern region in Turkey where this type of marriage is common. According to previously studies, polygamous wives, especially senior ones have more intense psychological distress.

Aim:

This study aims to study the relationship between polygamous marriage and various socio-demographic variables, self-esteem, depressive symptoms and psychiatric disorders.

Method:

The study consisted of a total of 108 women above the age of 18, of whom 72 were involved in polygamous marriages (30 women were senior wives and 42 women were junior wives) and 36 were in monogamous marriages. Participants were assessed using the Rosenberg Self-Esteem Scale (RSE) and Beck Depression Inventory (BDI). Psychiatric disorders were diagnosed by DSM5-based psychiatric interview.

Results:

The average age was 45.73 ± 15.22 years for senior wives, 36.57 ± 10.26 years for juniors and 33.94 ± 9.08 years for monogamous ones. Although the senior and junior wives were scored higher in the RSE, the difference was not statistically significant. Senior wives tended to score higher in BDI. In the analysis of variance (ANOVA), a significant difference was found between senior wives and monogamous wives but not between junior wives and monogamous wives. The frequencies of dysthymia, posttraumatic stress disorder, somatic symptom disorder and panic disorder among senior wives were significantly higher than in the other groups. Moreover, the frequency of dysthymia was significantly higher among the junior wives compared to the monogamous wives.

Conclusion:

Polygamous wives are designated to be a disadvantaged subgroup in respect to mental health practices. Mental health professionals, lawmakers and policy planners should put an effort to increase awareness of the relation of polygamy with psychiatric disorder.
Hormonal Contraception and the Informed Consent*
Authors: Hilger David J. , Raviele Kathleen M. , Hilgers Teresa A.
Published: December 2018

Since the 1960s, hormonal contraceptives have become the most commonly used method of pregnancy prevention in the United States and the world. Oral contraceptives are used by a large percentage of women, including Christian women. There are known health risks to women demonstrated in research published since Pope Paul VI’s prophetic encyclical Humanae vitae in 1968. These risks include venous thrombosis, cardiovascular risks, and an increased risk of cancer. These risks are medically recognized with continued scientific debate on the degree. The risks are significantly increased with preexisting conditions and in certain demographic groups. Discussing known and potential treatment risks is a standard that is both accepted by the medical community and is increasingly expected by patients. This discussion can be accomplished by the mechanism and principle of informed consent. Depending on the circumstances, abstinence or fertility awareness-based methods (FABMs) should be presented to patients. FABMs are licit, safe, and effective methods of pregnancy prevention. Informed consent is the most effective means of providing patients with pertinent information on the significant risks of contraception.

This article discusses the use of the informed consent to provide patients with information on the medical and ethical risks of oral contraceptives. FABMs and abstinence are presented as effective, safe, and licit preferences to oral contraceptives. Discussing known and potential treatment risks is accepted by the medical community and expected by patients (shared decision making). The authors discuss the historical context of Pope Paul VI’s encyclical Humanae vitae in relationship to the development and rapid adoption of oral contraceptives.
Clarifying Indeterminate Results on the Rabies Direct Fluorescent Antibody Test Using Real-Time Reverse Transcriptase Polymerase Chain Reaction
Authors: Appler Kim , Brunt Scott , Jarvis Jodie A. , Davis April D.
Published: December 2018

Objectives:

Each year, rabies virus infection results in the death of more than 50 000 persons worldwide. In the United States, the Centers for Disease Control and Prevention (CDC) reported 23 human rabies cases from May 1, 2008, through October 1, 2017. Although rabies testing in the United States is highly reliable, some specimens submitted to rabies laboratories do not have adequate tissues or may be substantially decomposed. In these instances, the specimen may be considered unsatisfactory for testing or produce indeterminate results using the gold standard direct fluorescent antibody test. The objective of this study was to evaluate the number of unsatisfactory samples or samples with indeterminate results that were positive for rabies virus after additional testing using real-time reverse transcriptase polymerase chain reaction (RT-PCR).

Methods:

In 2016, we retested all unsatisfactory specimens or specimens with indeterminate results using real-time RT-PCR. We further typed any sample that was real-time RT-PCR positive to identify the infecting rabies virus variant.

Results:

Of 210 retested unsatisfactory specimens or specimens with indeterminate results, 9 (4.3%) were positive for rabies. In each case, the animal was infected with a homologous rabies virus variant.

Conclusion:

These results confirm the recommendation by CDC and state public health laboratories that indeterminate results should be considered positive and justify the prompt treatment of exposed persons through an animal that is suspected to have rabies.
Urban consolidation, power relations, and dilapidated residential redevelopment in Mutoulong, Shenzhen, China
Authors: Li Xiang , Han Sun Sheng , Wu Hao
Published: December 2018

Recent policy initiatives for urban development have changed the relationships among stakeholders in China’s urban consolidation processes. Building upon Giddens’ (Giddens A (1984) The Constitution of Society: Outline of the Theory of Structuration. Berkeley, CA: University of California Press.) structuration theory and Ostrom’s (Ostrom E (2005) Understanding Institutional Diversity. Princeton, NJ: Princeton University Press) institutional analysis and development thesis, this paper develops a power arena analytic framework, and uses it to examine the new power relations among the stakeholders in a dilapidated residential redevelopment project in Shenzhen. Our findings reveal that Shenzhen’s new approach incentivised the developer to frame a local decision-making structure which aligned the property owners into two broad groups: those who supported the developer, or cooperative, and those who disputed with the developer, or un-cooperative. Shenzhen’s new attempt was unable to balance power distribution between the main stakeholders and caused intense conflicts and poor project outcomes. A range of factors, including passive participation of residents in project preparation, weak mechanisms to curb speculation, and policy inconsistency associated with tiers of governments, were responsible for the poor performance. These findings contribute to the understanding of the complexity in power relations underlying urban development influenced by planning policy.
Format of Instructor Feedback on Student Writing Assignments Affects Feedback Quality and Student Performance
Authors: Johnson William F. , Stellmack Mark A. , Barthel Abigail L.
Published: December 2018

Electronic feedback given via word-processing software (e.g., track changes in Microsoft Word) allows for a simple way to provide feedback to students during the drafting process. Research has mostly focused on student attitudes toward electronic feedback, with little investigation of how feedback format might affect the quality of instructor comments. In this study, we experimentally manipulated the feedback format, either electronic or handwritten, used by instructors grading papers in an introductory research methods course. Among the effects observed, instructors using electronic feedback provided longer comments, were less likely to rewrite student passages and were more likely to offer general observations about the writing. Students whose papers were graded using electronic feedback also showed greater improvement on subsequent drafts.
History as Organizing: Uses of the Past in Organization Studies
Authors: Wadhwani R. Daniel , Suddaby Roy , Mordhorst Mads , Popp Andrew
Published: December 2018

Research on the “uses of the past” in organizations and organizing is flourishing. This introduction reviews this approach to integrating history into organization studies and explores its paths forward. We begin by examining the intellectual origins of the approach and by defining why and how it matters to the study of management and organizations. Specifically, we emphasize the performative role of history in making and unmaking organizational orders. Next, we elaborate on how the articles in the special issue demonstrate the uses of the past in shaping organizational identity, strategy, and power. We also highlight how this work contributes to our understanding of the socially embedded character of history in organizations by accounting for the role of materiality, intertextuality, competing narratives, practices, and audiences in how the past is used. We conclude by considering four research frontiers particularly worthy of further exploration—the influence of temporal form, the role of non-rational knowledge, the range of methods, and the integration of ethics—in studies of the uses of the past in organizations.
Much Ado About Nothing and pain
Authors: Hunt Maurice
Published: December 2018

Shakespeare’s Much Ado About Nothing especially focuses upon pain. A great build-up of physically but mainly verbally caused pain dissolves in the play’s final episodes. This essay explores this paradox by analysing the pain Beatrice and Benedick, Don John, Claudio and Hero, Leonato and Anthony feel and mutually inflict. Variously charged by local dramatic contexts, such suffering invites the application of past and contemporary theories of pain for its fullest interpretation in this comedy. The possibility of empathy depends in the case of Much Ado upon this application.
Long‐term Outcome for Open and Endoscopically Resected Sinonasal Tumors
Authors: Hagemann Jan , Roesner Jana , Helling Soenke , Jacobi Christian , Doescher Johannes , Engelbarts Matthias , Kuenzel Julian , Krauss Philipp , Becker Sven , Betz Christian Stephan
Published: December 2018

Objective

Endoscopic resection of sinonasal cancer has become an alternative to open craniofacial surgery and leads to safe and satisfying results in emerging numbers. Randomized study data comparing outcomes between approaches are missing. Hence, it remains unclear which subgroups of patients might profit most from each technique. We aimed to identify such patient and tumor characteristics and gather information for future prospective study design.

Study Design

Case series with chart review.

Setting

Tertiary academic center.

Subjects and Methods

This study is based on a retrospective chart review of 225 patients undergoing open craniofacial or endoscopic resection for sinonasal malignancy between 1993 and 2015 at Munich University Hospital. Statistical analyses include t test, chi‐square, Kaplan‐Meier charts, and univariate and multivariate analyses.

Results

The sample size was similar between the endoscopic and open surgery groups. Tumors were significantly larger in patients who underwent open craniofacial resection. The risk of notable bleeding (P =. 041) was lower and hospital stay shorter (P =. 001) for endoscopic interventions of all tumor stages. Rates of overall (P =. 024) and disease‐specific (P =. 036) survival were significantly improved for endoscopic cases; improved recurrence‐free survival rates did not achieve statistical significance (P =. 357). For cases matched for tumor size, this improvement was confirmed for T3 tumors (P =. 038). Regional and distant metastatic tumor spread generally worsened survival in both surgical subgroups. Multivariate Cox regression analysis revealed independent prognosticators for overall survival.

Conclusion

Endoscopic tumor resection remains a suitable option for distinct indications and showed improved outcome in intermediate‐stage tumors in our collective. Further randomized studies acknowledging the here‐identified factors are needed to improve future therapy guidelines and patient care.
Intratympanic Dexamethasone via Saturated Gelfoam for Idiopathic Sudden Sensorineural Hearing Loss
Authors: Lundy Larry , Karatayli Ozgursoy Selmin , Kleindienst Samantha
Published: December 2018

The duration of contact time of intratympanic steroids at the round window is a variable that can potentially affect the ultimate concentration within the cochlea. By placing Gelfoam saturated with dexamethasone directly over the round window, contact time is prolonged and potentially increases the dexamethasone concentration within the cochlea. This technique is simple, readily available with standard instruments and ingredients, and easily done in the office.
Isoniazid-loaded chitosan/carbon nanotubes microspheres promote secondary wound healing of bone tuberculosis
Authors: Chen Gangquan , Wu Yaling , Yu Dongping , Li Rubing , Luo Wenyuan , Ma Guifu , Zhang Chao
Published: December 2018

Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross many kinds of physiological barriers. Here, we constructed a chitosan/carbon nanotubes nanoparticles to control slow release of isoniazid. Transmission electron microscopy and nanoparticle tracking and analysis results showed that the diameter of chitosan/carbon nanotubes nanoparticles was between 150 and 250 nm. Chitosan/carbon nanotubes nanoparticles significantly prolonged the release time of isoniazid, and the release rate was more uniform, no sudden release was observed. In vitro experiments showed that chitosan/carbon nanotubes nanoparticles did not destroy biological function of isoniazid, but could reduce its cytotoxicity and inflammation. We further constructed animal model of tuberculous ulcer. The results showed that isoniazid/chitosan/carbon nanotubes nanoparticles promoted the healing of tuberculosis ulcer. Compared with isoniazid group and isoniazid/carbon nanotubes group, the area of wounds decreased by 94.6% and 89.8%, respectively. Immunohistochemistry showed that CD3+ and CD4+ T cell number decreased significantly in isoniazid/chitosan/carbon nanotubes group. In conclusion, we constructed a kind of isoniazid/chitosan/carbon nanotubes nanoparticles, which can significantly promote the healing of tuberculosis ulcer. Our study provided an effective way for the treatment of secondary wound healing of bone tuberculosis.
Analysis of the initiation and propagation of fatigue cracks in the CRTS II slab track inter-layer using FE-SAFE and XFEM
Authors: Xiao Hong , Zhang Yan-rong , Li Qi-hang , Jin Feng , Nadakatti Mahantesh M
Published: December 2018

In this study, a novel method for analysing inter-layer defects in slab tracks was proposed, based on fatigue analysis and the extended finite element method. The inter-layer gap of China Railway Track System (CRTS) II slab tracks was analysed. First, a finite element model was established to analyse the stresses in mortar layer under train and temperature loading. Secondly, the results of the stress analysis of the mortar layer were assessed using a fatigue analysis software for calculating the fatigue life of the mortar layer and the areas that fail first. Finally, in an extended finite element analysis, an initial gap was applied over the area that fails first, as determined through the fatigue analysis of the mortar layer. The patterns of the gaps at the ends, in the central part of the edge, and at the corner of the inter-mortar layer were observed and compared. Results show that the new method, which combines fatigue analysis and the extended finite element method, can address the discontinuity problem of the inter-layer slab defects in ballastless tracks, enabling the development process to be simulated. The rate at which the area of gapping increases can be used to characterize the development of the inter-layer gap in slab tracks.
Temporal Proximity Links Unrelated News Events in Memory
Authors: Uitvlugt Mitchell G. , Healey M. Karl
Published: December 2018

Some memories are linked such that recalling one can trigger the retrieval of another. What determines which memories are linked? Some models predict that simply occurring close together in time is sufficient for links to form between memories. A competing theory suggests that temporal proximity is generally not sufficient, and existing evidence for such links is an artifact of using chainlike lists of items in artificial laboratory tasks. To test these competing accounts, we asked subjects to recall news stories that they had encountered over the past 2 years (Experiment 1) or 4 months (Experiment 2). In both experiments, subjects showed a strong bias to successively recall stories that appeared in the news within days of each other—even after accounting for the fact that stories that occur close in time tend to be semantically related. By moving beyond laboratory tasks, this research solidifies the foundation of contemporary memory theory.
Bone turnover markers in relation to vitamin D status and disease activity in adults with systemic lupus erythematosus
Authors: Sarkissian A , Sivaraman V , Bout-Tabaku S , Ardoin S P , Moore-Clingenpeel M , Mruk V , Steigelman H , Morris K , Bowden S A
Published: December 2018

Objective

Patients with systemic lupus erythematosus (SLE) have altered bone metabolism and are at risk of osteoporosis. The aim of this study was to examine bone turnover markers in relation to vitamin D, disease activity, and clinical risk factors in patients with established SLE.

Methods

Clinical registry and biorepository data of 42 SLE patients were assessed. Serum samples were analyzed for osteocalcin as a marker of bone formation, C-terminal telopeptide of type 1 collagen (CTX) as a marker for bone resorption, and 25-hydroxy vitamin D.

Results

Patients with a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI) score of 3 or greater had a lower median osteocalcin level ( P = 0.02) and lower 25-hydroxy vitamin D levels ( P = 0.03) than those with a score of less than 3. No significant differences in bone turnover markers were observed between patients dichotomized into subgroups using a 25-hydroxy vitamin D cut-off of 30 ng/mL or by a daily prednisone dose greater than or 5 mg or less. Osteocalcin levels were negatively correlated with SLEDAI scores ( P = 0.034), and were positively correlated with the CTX index (a ratio of measured CTX value to the upper limit of the normal value for age and gender) ( P < 0.01). No association between the CTX index and SLEDAI scores was found.

Conclusion

SLE disease activity may have direct effects on bone formation, but no effects on bone resorption in this cohort of established SLE patients, probably related to the inflammation-suppressing effects of glucocorticoids, thereby inhibiting cytokine-induced osteoclast activity. A fine balance exists between disease control and the use of glucocorticoids with regard to bone health.
The Vexing Volunteer’s Dilemma
Authors: Krueger Joachim I.
Published: December 2018

A volunteer’s dilemma exists when a prosocial act such as volunteering leaves the volunteer better off than if no one had volunteered but worse off than if someone else had volunteered. Ideally, a person would do what others are not doing. Research has identified psychological processes and judgmental heuristics affecting the likelihood of volunteering. People volunteer inasmuch as the other person is psychologically close, they project their own choice to others, they believe that they volunteer more than others, and they ascribe moral value to volunteering. These heuristics promote volunteering and tend to create value, but they also create risks of overvolunteering. These heuristics are discussed in the context of egocentric perception and concern with reputation.
Religious Coping in Iranian Mothers of Children With Cancer: A Qualitative Content Analysis
Authors: Nikfarid Lida , Rassouli Maryam , Borimnejad Leili , Alavimajd Hamid
Published: December 2018

Objective: Religious coping is one of the most frequently used coping methods in parents of children with cancer. This study aims to explain dimensions of religious coping in mothers of children with cancer in Iran. Methods: In this qualitative content analysis, using purposeful sampling, 8 mothers of children with cancer were selected and interviewed. When saturation was achieved, data were analyzed through directed content analysis. Primary and secondary codes were placed in prelabeled categories and subcategories based on Pargament’s religious coping theory. Results: The participants of the study used coping methods in 4 of the 5 objectives of religious coping, that are meaning, control, comfort, and intimacy with others and closeness to God. Three of the most frequent used coping methods by the participants were “Punishing God Reappraisal,” “Pleading for Direct Intercession,” and “Benevolent Religious Reappraisal,” respectively. None of the participants used religious coping methods for its function of “life transformation.” Conclusions: As suggested by Pargament’s theory of religious coping, the dynamic, multidimensional process of religious coping has a culture-based pattern with unpredictable outcomes. Despite many similarities between religious coping in a Shia Muslim society and other studied ones, some differences are observed. Further studies are needed to show the potential evidence of the concept in relation to cultural diversity and religious differences.
Morphological and Immunohistochemical Biomarkers in Distinguishing Prostate Carcinoma and Urothelial Carcinoma: A Comprehensive Review
Authors: Sanguedolce Francesca , Russo Davide , Mancini Vito , Selvaggio Oscar , Calò Beppe , Carrieri Giuseppe , Cormio Luigi
Published: December 2018

The differential diagnosis between high-grade prostate carcinoma and infiltrating urothelial carcinoma (UC) in transurethral resection prostate specimens as well as cystoprostatectomy specimens may often be challenging due to morphologic and clinical overlap of the 2 entities. Such distinction has critical therapeutic and staging consequences, yet it is hampered by both issues in morphology and by the low accuracy rates of single immunohistochemical markers, as reported in literature. This review aims to provide a comprehensive analysis of the available morphological and immunohistochemical parameters, which may allow to discriminate between prostate carcinoma and urothelial carcinoma in the proper clinical context and to discuss their diagnostic applications in daily practice.
Science Communication Is Culture: Foregrounding Ritual in the Public Communication of Science
Authors: Blue Gwendolyn
Published: December 2018

This commentary demonstrates the relevance of James Carey’s ritual view of communication for the field of science communication. A ritual view of communication invites examination of the geographical, historical, and material dimensions of communication where dialogues, bodies, public spaces, and comestibles provide enabling conditions for democratic engagement. This is an opportune time for science communications scholars to engage with Carey’s ideas as the field moves from deficit accounts of communication to the dialogic and cultural models that have become more prevalent in recent decades. A ritual view highlights the importance of theoretical, humanist approaches as complements to empirical, instrumental accounts of science communication.
Effect of ozone treatment on the microstructure, chemical composition and sensory quality of apple fruits
Authors: Juhnevica-Radenkova Karina , Radenkovs Vitalijs , Kundzins Karlis , Seglina Dalija
Published: December 2018

The aim of this study was to assess the effect of O3 treatment on the quality of different cultivars of apples ( Malus domestica Borkh.). Apples were stored for six months at different concentrations of ozone. During the research, minor differences between ozone-treated and control fruits were found in terms of cell integrity and epicuticular wax structure. Ozone application for apple treatment could accelerate the natural ageing of the waxes found on the surface of apples, thereby reducing the thickness of the waxes. The rate of degradation for the epicuticular wax was found to be cultivar dependent. After six months of storage, the ozonation process prevented the decay of ‘Iedzenu’, ‘Auksis’ and ‘Belorusskoje Malinovoje’ apple cultivars, but it accelerated damage in the ‘Gita’ apple cultivar. A positive impact of ozone during long-term storage was found regarding flesh firmness of ‘Iedzenu’ apple cultivar samples subjected to O3 exposure at concentrations of 0.8 ppm and 3.0 ppm. In other cultivars of apples, significant differences between ozonation and cold storage (control) were not found. In general, ozone treatment has a potential to be applied in order to maintain the sensory quality and biologically active compound level in apples during six-month storage; however, the degree of effectiveness depends both on the cultivar and on the concentration of ozone.
“Treated me … like I was family”: Qualitative Evaluation of a Culturally-Adapted Health Care Manager Intervention for Latinos with Serious Mental Illness and at Risk for Cardiovascular Disease
Authors: Cabassa Leopoldo J. , Manrique Yamira , Meyreles Quisqueya , Capitelli Lucia , Younge Richard , Dragatsi Dianna , Alvarez Juana , Lewis-Fernández Roberto
Published: December 2018

Latinos with serious mental illness (SMI) experience health and health care disparities and may benefit from interventions that improve access to, coordination of, and receipt of primary care services. The aim of this qualitative study was to examine the experiences of Latinos with SMI and at risk for cardiovascular disease participating in Bridges to Better Health and Wellness (B2BHW), a culturally-adapted health care manager intervention delivered in a public outpatient mental health clinic. A total of 29 Latino participants completed a post-intervention survey that included an open-ended question about the three things they liked most about B2BHW; a subset of 16 participants participated in one of three post-intervention focus groups. Results indicate that what mattered most to participants was the health education they received, the positive relationships they formed with their health care managers, the care coordination assistance they obtained, and the motivation and activation they gained from this intervention. Study findings suggest that key elements of the health care manager intervention (e.g., care coordination, and patient activation) shaped participants' experiences with B2BHW and were perceived as beneficial.