bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Sentimen Terhadap Tokoh Publik Menggunakan Support Vector Machine
Authors: Fitriyani Nurul Khasanah , Hartanto Anggit Dwi
Published: October 2021

Anies Baswedan adalah seorang gubernur DKI Jakarta yang menjabat pada masa bakti 2017-2022. Pada bulan Desember 2019 ini nama Anies Baswedan hangat diperbincangkan di berbagai media karena pemberian penghargaan Adikarya Wisata 2019 sebuah diskotek yaitu ke Diskotek Colosseum meskipun pada akhirnya penghargaan tersebut dicabut kembali. Namanya juga hangat diperbincangkan karena dianggap cuci tangan setelah mencopot dua pejabat karena dua masalah yang berbeda. Kemudian juga mengenai masalah banjir yang terjadi di Jakarta, namanya juga disebut belum bisa menangani dengan baik banjir yang selalu terjadi di Jakarta. Media twitter memiliki tampilan simpel, topik terupdate, terbuka dalam mengakses tweet dan cepat dalam menyampaikan opini. Dari berbagai komentar dan tanggapan di Twitter diperlukan teknik untuk membagi ke dalam kelas opini negatif atau positif. Penelitian ini, menggunakan preprocessing dan melabeli opini kedalam kelas positif dan negatif. Sedangkan untuk klasifikasinya menggunakan metode Support Vector Machine. Data yang digunakan berupa opini tentang seseorang Anies Baswedan dari media sosial Twitter yang berjumlah 1000 tweet yang diambil pada tanggal 17 Desember 2019. Dari hasil pelabelan didapatkan banyaknya komentar positif berjumlah 429 dan yang berkomentar negatif berjumlah 530. Sedangkan klasifikasi metode Support Vector Machine mendapatkkan nilai akurasi sebesar 95,9%, nilai presisis sebesar 94,49%, dan nilai recall sebesar 96,4%.
Implementasi Metode Profile Matching untuk Penentuan Mahasiswa Berprestasi
Authors: Siagian Edward Robinson
Published: October 2021

Decision support systems developed at the beginning of the era of distributed computing and began to develop in the 1960-1970s, as a result of a number of other factors: hadware and software technology, research efforts by academics from universities, began to grow awareness of the support of a decision and the desire to obtain better information. In this study, a case will be raised, which is looking for the best alternative based on student competence in the "XYZ" educational institution by applying the profile matching method. This method was chosen because it is able to select the best alternative from the aspects of existing criteria. The study was conducted to find the value of weight for each aspect, such as examples of academic aspects and non-academic aspects of students, then the ranking process of selected prospective students who have been selected, and the output of the application can help decision makers in choosing alternative students who excel.
Rekomendasi Penentuan Desa Terbaik dengan Kombinasi Metode OWA (Ordered Weighted Avarage) dan Metode SAW (Simple Additive Weighting) berbasis Web
Authors: Simangunsong Agustina , Hamdani Rita
Published: October 2021

The success of the government is determined by essential aspects of the village and has increased every day and has changed into a town that has independence in carrying out activities and survival by each of its residents, to support and improve the quality of government villages which motivate for villages to compete to become the best village through a series of costs to improve the quality of the town. The process of determining the best village starts from the sub-district. The winner will be smart at the city district level up to the national level, in the process of determining the best town according to government regulations in sending villages with five aspects and each aspect that has specified specifications and through validation from the government In the process of the government in the form of a committee conducting visits and conducting assessments based on the completeness of the data with the team for each aspect and giving to the committee based on individual orders, the value submitted will do the calculation by determining the final cost of the process of finding an average value -average overall and do the division of the total aspects. To assist the procedure in choosing the best village, the researcher wants to develop an online decision support system application with features that will be equipped in the developed application by uploading documents according to conditions in the field and documentation carried out by the team towards the village, so that the order process is open. It can be witnessed by all concerned, while in the Calculation and analysis Process using the OWA (ORDERED WEIGHTED AVERAGE) combination operator to determine the average value calculation and the SAW (Simple Additive Weighting) Method as part of the ranking of several existing villages
Sistem Informasi E-Direktori dalam Peningkatan Kualitas Layanan Perguruan Tinggi
Authors: Simanjorang R. Mahdalena , Damanik Marlen Jhonhari
Published: October 2021

Saat ini penggunaan teknologi informasi sudah banyak diterapkan di perguruan tinggi. Adapun yang menjadi kendala dalam pelaksanaan akademis yaitu pada proses pemberkasan pada Perguruan Tinggi. STMIK pelita Nusantara merupakan salah satu perguruan tinggi swasta dan banyak hal yang harus diperhatikan. Yaitu seperti proses pelaksanaan akademik, Pelaporan BKD (Beban Kerja Dosen), pengajuan kepangkatan dan golongan. Cara yang sering digunakan pada pelaksanaan akademis yaitu dengan memfilekan berkas mahasiswa termasuk dosen dalam bentuk hardcopy. Sama hal nya dengan pelaksanaan akreditasi berkas berkas harus dibuat yang baru. Adapun yang menjadi permasalahan yang sering muncul yaitu dengan menyimpan berkas dalam suatu tempat yang sama dan menggabungkan antara berkas yang satu dengan berkas yang lain. Pada proses pencarian berkas yang dilakukan tentu memakan waktu yang lama sehingga prosedur ini tidak efektif dan efisien. Sehingga banyak pihak yang dirugikan ketika melakukan pencarian berkas penting. Tujuan dilakukan penelitian ini adalah dengan adanya aplikasi E-Direktori nantinya tentu sangat membantu pihak terkait seperti tim manajemen dan dosen dalam pemberkasan sehingga mudah diterapkan nantinya seperti pada proses akreditasi.
Rancang Bangun Aplikasi Cerdas Menentukan Bakat Anak Dengan Teorema Bayes Berbasis Android
Authors: Hasugian Penda Sudarto , Simbolon Liber
Published: October 2021

All children are born with unique personalities and talents, and of course, parents want to always give the best for their children, such as a place to play, clothing, food and education. In terms of education, there are still many parents who do not see what their children want or like to learn and what their children don't enjoy. But parents impose a desire on their child to learn a subject that the child does not select or want so that the child tends to be forced to learn and results in not optimal results. This problem is the background for making smart applications to determine children's talents with the Android-based Bayes theorem based on early childhood personality. This intelligent application built on an Android basis with the Bayes theorem can help parents or the general public to find out the talents of each child from an early age. So that education, the lessons that will be taken by a child are appropriate and have qualified skills. This type of research is a development research category, namely producing application products that can be used by the general public, the research process involves experts in the field of psychology by way of direct communication to create data used in determining children's talents from an early age.
Seleksi Pemilihan Karyawan Terbaik Menggunakan Metode Profile Matching
Authors: Akbar Muhammad Dean , Mufty Mufty
Published: October 2021

Appreciation of a performance for the best employees is something that must be done by a company to encourage employees to be more enthusiastic in working. Reward is given to employees who have performed the best in the last year, while the awarding of a letter of reprimand is given to employees who have very poor performance. the selection of the best employees so far is based only on attendance and observation from the assessment of performance in one year regardless of other criteria of assessment. so there are often mistakes in choosing the best employees. in this study using Profile Matching method in performing calculations and employee rank. The results showed that employees on behalf of Serly were selected as the best employees with a score of 4.96
Rancang Bangun Sistem Pakar untuk Diagnosa Penyakit Mulut dengan Menggunakan Teorema Bayes Berbasis Android
Authors: Panjaitan Muhammad Iiqbal , Rahmi Elvika
Published: October 2021

The lack of knowledge of oral health and limited sources of information causes low public awareness of oral health and also causes people to be reluctant to have their oral health checked by a doctor due to the high cost of consultation. The expert system for diagnosing oral diseases is expected to provide knowledge about the diagnosis of oral diseases, provide media for consultation on diseases of the mouth and reduce the number of consultation costs. Expert system (expert system) is a system with working principles by trying and adopting knowledge that is owned by humans and transferred to the computer, so that the computer can solve problems as usually done by experts. Bayes' Theorem is a way of finding conditional probabilities. Conditional probability is the probability of an event occurring, given that it has some relationship with one or more other events. This expert system application uses Android as the operating system. The Android-based operating system is an operating system that is open source so that it is easy to develop and optimize. The results of this study are an expert system application that can provide knowledge about the diagnosis of oral diseases, becoming a medium for consultation on oral diseases.
Consideraciones fisiológicas sobre la reanimación cardiopulmonar. ¿Qué se puede aprender para realizar una mejor reanimación cardiopulmonar?
Authors: Cairol Andres , Morún Vargas Wendy , Arguedas Hernández Erick
Published: October 2021

La parada cardiaca corresponde a un evento cuya supervivencia oscila cerca del 6.4 %. Nuestro país posee un reto importante para trabajar en la calidad de la reanimación cardiopulmonar, por lo tanto, entender la fisiología corresponde a un esfuerzo en ese sentido. Se enfatiza en las compresiones de calidad, pues generan un gradiente de presión entre la aorta y la aurícula, el cual es un factor importante en la presión de perfusión coronaria, aspecto que está asociado a la sobrevida. Para proveer una adecuada reanimación se deben entender sus diferentes fases y así efectuar una intervención positiva.
¿Cómo interpretar un examen general de orina?
Authors: Padilla Cuadra Juan Ignacio
Published: October 2021

El examen de orina es una prueba de uso rutinario en medicina. Esta herramienta es relativamente simple y permite hacer diagnóstico de numerosas entidades renales, urológicas y sistémicas. Se presentan a continuación elementos fundamentales sobre este examen.
Tabaquismo en Estudiantes de Ciencias de la Salud: Encuesta de prevalencia, conocimientos y actitudes
Authors: Padilla Cuadra Juan Ignacio , Hernández Lindsay
Published: October 2021

Introducción: El tabaquismo es un hábito asociado a numerosas enfermedades, evitarlo o promover su cesación es parte fundamental de las intervenciones de los profesionales en medicina y en otras ciencias de la salud. Se propuso un estudio basado en una encuesta dirigida a estudiantes de ciencias de salud de nuestra Universidad en la que se evaluaron prevalencia, conocimientos y actitudes sobre este nocivo hábito
Técnica Espiral de Valoración Rápida de la Tomografía de Cráneo
Authors: Padilla Cuadra Juan Ignacio
Published: October 2021

El análisis profundo de la tomografía de cráneo es competencia de especialistas en radiología, neurología y neurocirugía. Sin embargo, el médico general debe conocer fundamentos para su interpretación práctica y detectar padecimientos graves que requieren intervención inmediata. Se propone un método sencillo para ordenar la manera en que visualizan estos estudios y como detectar hallazgos relevantes. Se muestran imágenes características de estos hallazgos para mejorar la habilidad del estudiante en su reconocimiento
Historia de los Antimicrobianos
Authors: Padilla Cuadra Juan Ignacio
Published: October 2021

El desarrollo de los antimicrobianos marcó un hito en la medicina en tanto que permitió controlar las infecciones como una de las principales causas de muerte. Para conocer el desarrollo de los antimicrobianos, es necesario desarrollar la historia de cada uno de ellos o del grupo al que pertenece. Como otros logros de la medicina moderna, se notará que este involucra múltiples disciplinas, trabajo más allá del laboratorio e incluso, en algunos casos, la intervención de la suerte y hasta conflictos interpersonales.
Potential yield and yield gap analysis of sugarcane (Saccharum officinarum) using the DSSAT-CANEGRO model in different districts of Uttar Pradesh, India
Authors: R.S. SINGH  , K.K. SINGH  , A.H. BHENGRA  , S.M. SINGH  , GANESH PRASAD  , PRIYANKA SINGH  , MAMTA RANA  , G.B. GOHAIN
Published: October 2021

DSSAT-CANEGRO model have been used to determine crop potential yield over eight districts (viz; Muzaffarnagar, Shahjahanpur, Agra, Lucknow, Basti, Faizabad, Allahabad and Jhansi) representing different agroclimatic conditions & environmentof Uttar Pradesh state in India. The thirty six years (1980-2016) daily weather data of above districts were used to simulate seasonal yield potentials under the various management conditions and compared with the respective district reported yield. The simulated mean potential yield by the CANEGRO model over different district of the state varied between 77.8 t ha-1 in Muzaffarnagar and 97.8 t ha-1 in Agra, while mean reported yield (fresh stalk mass) varied between 40.1 t ha-1 in Jhansi and 62.8 t ha-1 in Muzaffarnagar within the state. Similarly, the attainable yield by the model was simulated lowest of 65.1 t ha-1 in Shahjahanpur and the highest of 73.6 t ha-1 in Faizabad district. The management yield gap was between 9.0 to 30.0 t ha-1 while sowing yield gap was between 7.0 to 26.0 t ha-1 in different districts under study. Further it is not only interesting & surprising but also encouraging to growers that the trends in total yield gap at all the above districts in various agro-climatic zones were found decreasing (narrowed down) at the rate of 138.8 – 801.2 kg ha–1 year–1. Delayed planting by about 30 days in some of the districts resulted into a decrease in sugarcane yield to the tune of 106.7 to 146.7, 103.3 to 143.3 and 80.0 to 133.0 kg ha–1 day–1, respectively. Findings reveal that DSSAT crop simulation model can be an effective tool to aid in decision support system. Yield gap estimates using the past crop data and subsequent adjustment in planting window may help to achieve close to the potential yields.
Thermal energy requirement for tobacco caterpillar Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) development on artificial diet
Authors: SUBHASH CHANDER  , MAZHAR HUSAIN  , GUNDAPPA BARADEVANAL
Published: October 2021

Development and survival of tobacco caterpillar Spodoptera litura larvae and pupae were studied at each of seven constant temperatures, 15±1, 18±1, 21±1, 24±1, 27±1, 30±1 and 33±1°C, in incubators. Oviposition, in-cubation, larval and pupal periods were recorded at each of the temperatures. The survival from 1st instar to adult emergence ranged between a maximum of 60% at 24°C and 30% at each of 18°C and 33°C. Developmental duration of different larval instars and pupae declined with an increase in temperature from 15 to 33°C. The optimum temperature for larval and pupal survival in S .litura on artificial diet was observed to be 24°C. On the other hand, optimum temperature range for oviposition was observed to be 27-33°C.The relationship between temperature (T) and development rate (r) was established using linear regression to estimate the thermal constant (K) and development threshold (T0).Thermal constant for 1st to 6th larval instars were computed as 76.9, 90.9, 125, 83.3, 62.5, 90.9 and 200 degree days (DD), respectively, with corresponding development thresholds as 12.8, 11.7, 9.8, 10.3, 10, 10.9 and 13.2oC. Single developmental threshold for larval stage was computed as 13°C.These thermal constants and development thresholds can be used in developing mechanistic population simulation model, which in turn will facilitate the assessment of climate change impact on the pest.
SIMULATION AND MODELING OF INTEGRATED RENEWABLE ENERGY RESOURCES (HYDRO, SOLAR AND WIND ENERGY)
Authors: Dorji Sangay , Bhattarai Hemlal , Sharma Parashuram , Yoser Sonam , Singye Karma , Tenzin Jigme
Published: October 2021

Renewable energy sources are likely to become prominent in the future due to less environmental impact and energy cost escalation. However, due to its intermittent essence, it encourages us to integrate various renewable energy resources to improve the reliability and quality of power supply to the consumer. Henceforth, this paper emphasizes the integration of various renewable energy sources (RES) such as - photovoltaic (PV), wind energy (WE) and hydro-electric grid (HEG) systems through software simulation. The purpose of this research was to compare the end user power quality and reliability between isolated mode and integrated mode operation of the power system through the result analysis in MATLAB simulation. In this qualitative study, the required data on wind and solar of a particular place, Samdrup Jongkhar (Bhutan) were collected in the form of satellite recorded data (NASA and SolarGIS). The result from this study highlights the nature of energy output from isolated-mode operated power plants and integrated power plant systems. From the result analysis, it has been shown that the quality and reliability of energy output from an integrated power system is much higher as compared to the isolated-mode operated power plant.
On the Cultivation of Civic Friendship
Authors: Cherry Myisha ,   Philosophy Documentation Center
Published: October 2021

I examine the possibility of civic friendship to solve the problem of over-doing democracy, paying close attention to how it can counter affective polarization and social homogeneity. In Section I, I explore civic friendship as a solution to polarization. In section II, I argue that Talisse’s civic friendship—in the context of nonpolitical collaboration—is akin to Aristotle’s utility and pleasure-friendships. Given the nature of civic friendship, in Section III–VI I make amendments to Talisse’s proposal. I argue that if civic friendship is to address not only desaturation but polarization, and it has these Aristotelian features, then the cultivation of taste, equity, and ethical attentiveness are necessary.
Vol. 8. No 15. Introducció a «La pandèmia de COVID-19 i el seu impacte en el turisme en espais urbans»
Authors: Cañada Mullor Ernest , Navarro Jurado Enrique
Published: October 2021

Introducció a la sección monográfica Àgora coordinada por Ernest Cañada Mullor y Enrique Navarro Jurado.
importancia de la música de fondo: comunicación con el cliente
Authors: Loureiro Marlene
Published: October 2021

Objetivo del estudio: Demostrar cómo la música puede influir en el comportamiento del consumidor de forma positiva, siempre que se planifique para el público objetivo específico del espacio comercial.

Diseño/ Metodología/Enfoque: El entorno de los espacios comerciales presenta algunas variables independientes, como la música, los aromas y los colores, que pueden influir en el comportamiento del consumidor de forma positiva, siempre que se planifiquen para el público específico. En este sentido, la música ambiental puede influir en el comportamiento del consumidor de forma positiva, siempre que esté planificada para el público objetivo específico, ya que los diferentes estímulos musicales del entorno influyen en los individuos, acercándolos o alejándolos. En esta investigación se llevó a cabo un estudio de caso en una superficie comercial, con el fin de comprender si el género musical, así como el tempo de la música influyen realmente en la impresión que los clientes se llevan sobre el ambiente del espacio comercial. Para ello se llevó a cabo la observación participante y se aplicaron encuestas a los clientes de esta superficie comercial.

Resultados: Los resultados muestran que la música puede ayudar a los minoristas a aumentar sus ventas y hacer que su espacio comercial sea más atractivo para su público objetivo.

Limitaciones e implicaciones: A pesar de ser un estudio de caso, se puede demostrar que la música ambiental adecuada puede despertar ciertos estados de ánimo e intenciones de compra en torno a los productos que se venden en el espacio comercial y también que los diferentes géneros musicales cambian la percepción del tiempo que se pasa en ese espacio, contribuyendo a la fidelización de los clientes.

Originalidad/contribución: La música se considera desde hace mucho tiempo un medio eficaz para despertar estados de ánimo y comunicar de forma no verbal. Este artículo explora la importancia de la música asociada al marketing de consumo, como herramienta para cautivar a los clientes en los espacios comerciales.
Making Games for Impact
Authors: Squire Kurt
Published: October 2021

Designing games for learning: case studies show how to incorporate impact goals, build a team, and work with experts to create an effective game.

Digital games for learning are now commonplace, used in settings that range from K–12 education to advanced medical training. In this book, Kurt Squire examines the ways that games make an impact on learning, investigating how designers and developers incorporate authentic social impact goals, build a team, and work with experts in order to make games that are effective and marketable. Because there is no one design process for making games for impact—specific processes arise in response to local needs and conditions—Squire presents a series of case studies that range from a small, playable game created by a few programmers and an artist to a multimillion-dollar project with funders, outside experts, and external constraints.

These cases, drawn from the Games + Learning + Society Center at the University of Wisconsin–Madison, show designers tackling such key issues as choosing platforms, using data analytics to guide development, and designing for new markets. Although not a how-to guide, the book offers developers, researchers, and students real-world lessons in greenlighting a project, scaling up design teams, game-based assessment, and more. The final chapter examines the commercial development of an impact game in detail, describing the creation of an astronomy game, At Play in the Cosmos, that ships with an introductory college textbook.
Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration
Authors: Lamb Maureen C , Kaluarachchi Chathuri P , Lansakara Thiranjeewa I , Mellentine Samuel Q , Lan Yiling , Tivanski Alexei V , Tootle Tina L
Published: October 2021

A key regulator of collective cell migrations, which drive development and cancer metastasis, is substrate stiffness. Increased substrate stiffness promotes migration and is controlled by Myosin. Using Drosophila border cell migration as a model of collective cell migration, we identify, for the first time, that the actin bundling protein Fascin limits Myosin activity in vivo. Loss of Fascin results in: increased activated Myosin on the border cells and their substrate, the nurse cells; decreased border cell Myosin dynamics; and increased nurse cell stiffness as measured by atomic force microscopy. Reducing Myosin restores on-time border cell migration in fascin mutant follicles. Further, Fascin’s actin bundling activity is required to limit Myosin activation. Surprisingly, we find that Fascin regulates Myosin activity in the border cells to control nurse cell stiffness to promote migration. Thus, these data shift the paradigm from a substrate stiffness-centric model of regulating migration, to uncover that collectively migrating cells play a critical role in controlling the mechanical properties of their substrate in order to promote their own migration. This understudied means of mechanical regulation of migration is likely conserved across contexts and organisms, as Fascin and Myosin are common regulators of cell migration.
Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Authors: Rausser Shannon , Trumpff Caroline , McGill Marlon A , Junker Alex , Wang Wei , Ho Siu-Hong , Mitchell Anika , Karan Kalpita R , Monk Catherine , Segerstrom Suzanne C , Reed Rebecca G , Picard Martin
Published: October 2021

Using a high-throughput mitochondrial phenotyping platform to quantify multiple mitochondrial features among molecularly defined immune cell subtypes, we quantify the natural variation in mitochondrial DNA copy number (mtDNAcn), citrate synthase, and respiratory chain enzymatic activities in human neutrophils, monocytes, B cells, and naïve and memory T lymphocyte subtypes. In mixed peripheral blood mononuclear cells (PBMCs) from the same individuals, we show to what extent mitochondrial measures are confounded by both cell type distributions and contaminating platelets. Cell subtype-specific measures among women and men spanning four decades of life indicate potential age- and sex-related differences, including an age-related elevation in mtDNAcn, which are masked or blunted in mixed PBMCs. Finally, a proof-of-concept, repeated-measures study in a single individual validates cell type differences and also reveals week-to-week changes in mitochondrial activities. Larger studies are required to validate and mechanistically extend these findings. These mitochondrial phenotyping data build upon established immunometabolic differences among leukocyte subpopulations, and provide foundational quantitative knowledge to develop interpretable blood-based assays of mitochondrial health.
Measured and predicted freeze-thaw days frequencies in climate change conditions in central Poland
Authors: Bartczak Arkadiusz , Kaczmarek Halina , Badocha Michał , Krzemiński Michał , Tyszkowski Sebastian
Published: October 2021

The rate of progression of geomorphological phenomena is greatly influenced by freeze-thaw processes. In the face of air temperature increasing over the past few decades, a question of the future impact of these processes arises, notably in the temperate and cold climate zones. Using the mean, maximum and minimum daily air temperature data in the period 1951–2018 obtained from three weather stations located in the vicinity of Jeziorsko reservoir (central Poland), we have determined the mathematical correlation, described with a polynomial function, between the mean monthly air temperature and the monthly number of freeze-thaw days (FTD). A freeze-thaw day is a day when the maximum air temperature is above 0 °C while the minimum air temperature equals or is below this threshold. The number of FTDs within the study area averaged 64–71 and demonstrated a downward trend of 2–4 FTDs/10 years. The study period (1951–2018), includes a clearly marked distinct sub-period (1991–2018), when the reservoir was in operation, which experienced 58–68 FTDs. Considering the assumed rise in temperature, one should expect a further, though slightly slower, decline in the future number of FTDs. Depending on the accepted model of the temperature increase, which for the area of Poland (Central Europe) in the perspective of 30 years oscillates between +1.1 to +1.3 °C, the number of FTDs within the study area is expected to decline by −4.5 to −5.3 FTD, i.e. 6–7% and 5.4–5.5 FTD i.e. 8–9% respectively.
Estrogen receptor—positive breast cancer survival prediction and analysis of resistance–related genes introduction
Authors: Shuai Chen , Yuan Fengyan , Liu Yu , Wang Chengchen , Wang Jiansong , He Hongye
Published: October 2021

Background

In recent years, ER+ and HER2- breast cancer of adjuvant therapy has made great progress, including chemotherapy and endocrine therapy. We found that the responsiveness of breast cancer treatment was related to the prognosis of patients. However, reliable prognostic signatures based on ER+ and HER2- breast cancer and drug resistance-related prognostic markers have not been well confirmed, This study in amied to establish a drug resistance-related gene signature for risk stratification in ER+ and HER2- breast cancer.

Methods

We used the data from The Cancer Genoma Atlas (TCGA) breast cancer dataset and gene expression database (Gene Expression Omnibus, GEO), constructed a risk profile based on four drug resistance-related genes, and developed a nomogram to predict the survival of patients with I-III ER+ and HER2- breast cancer. At the same time, we analyzed the relationship between immune infiltration and the expression of these four genes or risk groups.

Results

Four drug resistance genes (AMIGO2, LGALS3BP, SCUBE2 and WLS) were found to be promising tools for ER+ and HER2- breast cancer risk stratification. Then, the nomogram, which combines genetic characteristics with known risk factors, produced better performance and net benefits in calibration and decision curve analysis. Similar results were validated in three separate GEO cohorts. All of these results showed that the model can be used as a prognostic classifier for clinical decision-making, individual prediction and treatment, as well as follow-up.
Phylogeny ofCrataegus(Rosaceae) based on 257 nuclear loci and chloroplast genomes: evaluating the impact of hybridization
Authors: Liston Aaron , Weitemier Kevin A. , Letelier Lucas , Podani János , Zong Yu , Liu Lang , Dickinson Timothy A.
Published: October 2021

Background

Hawthorn species (CrataegusL.; Rosaceae tribe Maleae) form a well-defined clade comprising five subgeneric groups readily distinguished using either molecular or morphological data. While multiple subsidiary groups (taxonomic sections, series) are recognized within some subgenera, the number of and relationships among species in these groups are subject to disagreement. Gametophytic apomixis and polyploidy are prevalent in the genus, and disagreement concerns whether and how apomictic genotypes should be recognized taxonomically. Recent studies suggest that many polyploids arise from hybridization between members of different infrageneric groups.

Methods

We used target capture and high throughput sequencing to obtain nucleotide sequences for 257 nuclear loci and nearly complete chloroplast genomes from a sample of hawthorns representing all five currently recognized subgenera. Our sample is structured to include two examples of intersubgeneric hybrids and their putative diploid and tetraploid parents. We queried the alignment of nuclear loci directly for evidence of hybridization, and compared individual gene trees with each other, and with both the maximum likelihood plastome tree and the nuclear concatenated and multilocus coalescent-based trees. Tree comparisons provided a promising, if challenging (because of the number of comparisons involved) method for visualizing variation in tree topology. We found it useful to deploy comparisons based not only on tree-tree distances but also on a metric of tree-tree concordance that uses extrinsic information about the relatedness of the terminals in comparing tree topologies.

Results

We obtained well-supported phylogenies from plastome sequences and from a minimum of 244 low copy-number nuclear loci. These are consistent with a previous morphology-based subgeneric classification of the genus. Despite the high heterogeneity of individual gene trees, we corroborate earlier evidence for the importance of hybridization in the evolution ofCrataegus. Hybridization between subgenusAmericanaeand subgenusSanguineaewas documented for the origin ofSanguineaetetraploids, but not for a tetraploidAmericanaespecies. This is also the first application of target capture probes designed with apple genome sequence. We successfully assembled 95% of 257 loci inCrataegus, indicating their potential utility across the genera of the apple tribe.
A review of Dendrobium kingianum Bidwill ex Lindl. (Orchidaceae) with morphological and molecular-phylogenetic analyses
Authors: Adams Peter B , Adams Sheryl , Renner Matthew AM
Published: October 2021

Populations of Dendrobium kingianum Bidwill ex Lindl. from near Newcastle, New South Wales to southern and central west Queensland and encompassing all regions of the distribution were studied using field observations, morphometric analysis and nrITS sequences. A total of 281 individuals were used to construct regional descriptions of D. kingianum and 139 individuals were measured for 19 morphological characters, and similarities and differences among specimens summarised using multivariate statistical methods. Patterns of morphological variation within D. kingianum are consistent with a single variable species that expresses clinal variation, with short growing plants in the south and taller plants in the northern part of the distribution. The nrITS gene tree suggests two subgroups within D. kingianum subsp. kingianum, one comprising northern, the other southern individuals, which may overlap in the vicinity of Dorrigo, New South Wales. The disjunct D. kingianum subsp. carnarvonense in central west Queensland, which can be distinguished by a predominately subterranean habit and a narrower labellum midlobe, was resolved sister to D. moorei, which renders D. kingianum paraphyletic in the nrITS gene tree, but this position was not supported. Regional descriptions documenting clinal variation are provided. All previously described varieties, including D. kingianum var. pulcherrimum Rupp, are colour and growth forms of D. kingianum subsp. kingianum.
Grevillea trichantha, a third species with hairy flowers in the Triloba Group (Proteaceae: Grevilleoideae: Hakeinae) from the Marchagee Track, south-west Western Australia
Authors: Olde Peter Maurice
Published: October 2021

Grevillea trichantha Olde, a rare species in the Triloba Group is described. It was discovered by the author in 2001 and appears to be most closely related to G. metamorpha Makinson, a rare, allopatric species known only from a single population on private land, west of the Brand Highway, in south-west Western Australia. Grevillea trichantha is the third species in the Triloba Group bearing floral organs on which hairs in various degrees of density are consistently distributed, notably on the outer surface of the perianth. A short key differentiating the three species is provided. Grevillea trichantha is more common than its comparator, G. metamorpha, but is still highly localised in distribution so deserves high conservation priority.
Lechenaultia peregrina, a new species of Goodeniaceae from northern Australia, New Guinea and the Moluccas
Authors: Barrett Russell L , Jobson Richard W
Published: October 2021

Morphological studies of Lechenaultia filiformis R.Br. have determined that more than one taxon is presently included under that name. We here recognise disjunct populations from north-east Queensland, north-east Northern Territory, New Guinea and the Moluccas as a new species, Lechenaultia peregrina R.W.Jobson & R.L.Barrett. This is the third tropical species of Lechenaultia currently recognised, however further studies are required to assess the status of about five additional entities in the Northern Territory and Western Australia currently included in L. filiformis s.l. Seed article morphology is critical for species delimitation in tropical Lechenaultia, but seed articles are often absent from collections, or only immature, as they fall quickly once ripe.
Análisis de los elementos de identidad de un espacio público. El caso del parque Juárez (Xalapa, México)
Authors: Egea-Jiménez Carmen , Nieto-Calmaestra José-Antonio
Published: October 2021

Los espacios públicos forman parte de la ciudad, le imprimen calidad, son elementos de identidad, construyen la imagen que se tiene de ella. Algunos se conciben en el momento del planeamiento y otros tienen su origen en procesos de reorganización, resignificación y/o reutilización del espacio. A esta segunda situación corresponde el parque Juárez de Xalapa, al ubicarse en el espacio que ocupó el convento de Santo Domingo (1556), manteniendo desde su inauguración (1892) el carácter de lugar de ocio. El artículo analiza la identidad de este espacio, marcada por ser un lugar central con características particulares en cuanto a estructura y uso, que lo convierten en un indiscutible punto de referencia de la ciudad. La metodología seguida en el presente trabajo es de carácter cualitativo y se basa en la información recogida en trabajo de campo (cuaderno de campo y registros fotográficos) y el análisis de las opiniones compartidas en Google Maps.
Dinámicas inmobiliarias y cambios en la morfología urbana del Gran Concepción
Authors: Prada-Trigo José , Aravena Natalia , Barra-Vieira Pablo
Published: October 2021

El peso del sector inmobiliario en la economía y el crecimiento urbano es un tema que ha atraído crecientemente la atención de los investigadores. Sin embargo, la mayoría de trabajos provienen de Europa, Estados Unidos y, recientemente, de las principales ciudades latinoamericanas. Este artículo contribuye a cubrir la ausencia de estudios sobre la red de ciudades secundarias de esta última región. Con tal fin, desarrolla un análisis e interpretación de las dinámicas de crecimiento urbano en el Área Metropolitana de Concepción (amc) en Chile, contextualizándolas entre procesos generales y especificidades locales a partir del estudio de sus procesos, mecanismos y morfologías. Se utiliza para ello una metodología cuantitativa-cualitativa que recurre al análisis espacial y entrevistas en profundidad.
¿Cerca o lejos? Discursos y subjetividad en las relaciones entre el lugar de residencia y la movilidad
Authors: Orellana Daniel , Hermida Carla , Hermida María-Augusta
Published: October 2021

La relación entre forma urbana y transporte ha sido un tema ampliamente estudiado en las últimas décadas. No obstante, el vínculo entre las preferencias de residencia y los modos de desplazamiento de las personas no ha sido suficientemente estudiado en Latinoamérica, a pesar de ser un factor determinante de los patrones de expansión urbana. En el presente trabajo se investigó esta relación para el caso de Cuenca, Ecuador. Con tal fin, se aplicó la Metodología Q, consistente en un conjunto de técnicas cuanti-cualitativas de análisis sistemático de la subjetividad. Se extrajeron y caracterizaron tres discursos predominantes en la ciudad en relación con preferencias de residencia y movilidad, que caracterizan diferentes perspectivas: un discurso orientado a la movilidad activa, otro orientado al transporte público, y finalmente uno orientado a la exclusividad y autosegregación. Esperamos que estudios como este contribuyan a la formulación de políticas que atiendan la diversidad de perspectivas de la población, y potencien las relaciones de proximidad.
Adult Shell-size Regulation in Conispirally-coiled Shells: Evidence for a Widespread Negative Covariance between Whorls Growth-rate and the Final Number of Whorls in Land Snails
Authors: Béguinot Jean
Published: October 2021

As shown, in particular, by the late S.J. Gould, the involvement of a regulation process, aiming at limiting the range of intraspecific variations in adult shell size, in those land snail species with determinate growth, can be indirectly, but conveniently, diagnosed by highlighting a negative covariance between the whorls growth-rate and the whorls number reached at adulthood. However, up to now, such kind of regulation had only been demonstrated in very few cases among land snails and shelled Gastropods in general. Accordingly, quite more extensive checking is required, across both the taxonomic spectrum and the geometrical range of shell profiles. The present report is a very preliminary contribution addressing these issues, which have been neglected for too long. Considering a still limited number of eight species, yet largely encompassing both taxonomic range and shell profiles, it is shown that strong negative covariances between whorls growth-rate and whorls number are systematically highlighted, thereby supporting the involvement of an efficient regulation process of adult shell size and shape in each eight species. Moreover, the degree of regulation of the adult shell size has been quantified and this regulation proves being remarkably effective as a whole, while yet remaining highly species-specific, with very significant disparities among species – and this, somewhat surprisingly, being quite irrespective of the type of geometrical profiles of shells, among the studied species.
Technological Pedagogical Content Knowledge: Testing the Assumptions with Teachers of Bhutan
Authors: Chophel Sangay
Published: October 2021

There has been an increased and rejuvenated interest in integrating technology in the day to day lives of the teachers, either due to forced circumstances or to catch up to the global education trend. Teachers’ knowledge and skills in using technology in the classroom is governed by Technological Pedagogical Content Knowledge (TPACK). While there is a plentiful of assumptions regarding the use of technology in the classrooms, this research investigated the technological components of the TPACK framework. Data was collected from 271 teachers in the various parts of the country. Using descriptive and inferential statistics, the scales in the TPACK was analyzed based on participants’ demographic information, such as age, gender, location of the school they are placed at, and teacher certification. Results suggests that there is a gender gap in the scales of TPACK, age and teacher certification are major variables on teachers’ competency and knowledge. Recommendations are discussed.
Effect of Irrigation and Herbicides on Most Tenacious Weed Cyperus rotundus in Wheat
Authors: Lakra Kairovin
Published: October 2021

To manage the Cyperus rotundus (Purple nut sedge.) is a troublesome, economically damaging weed, widely naturalized in the tropical and subtropical regions of the world. A field experiment was done at Students Instructional Farm of Chandra Shekhar Azad University of Agriculture & Technology, Kanpur (U.P).The study was conducted to investigate the competitive effects of C. rotundus in wheat (Triticum aestivum L.) under varying irrigation regimes and herbicides in field conditions at Kanpur during Rabi 2017-18 and 2018-19 in a split plot design.  The experiment was laid out in split-plot design with four irrigation schedule viz. irrigation at CRI and active tillering stage (I1), irrigation at CRI + jointing + booting (I2), CRI + active tillering + booting + flowering stage (I3) and  irrigation at CRI + jointing + booting + flowering + milking stage (I4) were assigned to main plots and weed management practices viz. W1-weedy check, W2-two hand weeding at 20 and 40 DAS, W3-sulfosulfuron @25 g/ha , W4- pendimethalin (pre emergence) fbWCPL-15(clodinafop- propargyl 15 %) @400 g/ha , W5- carfentrazone ethyl 20% + sulfosulfuron 25%WG @ 100 g/ha , W6- halauxafen + penxasulam 23.5% @ 75 g/ha , W7- halauxafen - methyl 1.21% w/w + fluroxypyr @  and W8- clodinafop- propargyl 15% + metsulfuron 1% @ 400 g/ha  were allocated to sub plots. Application of two irrigations at CRI and active tillering stage (I1) significantly reduced the density of C. rotundus and their fresh and dry weight with highest weed control efficiency (WCE) over irrigation at CRI+ jointing+ booting+ flowering+ milking stage (I4), irrigation at CRI + active tillering + booting + flowering stage (I3) and irrigation at CRI + jointing + booting (I2). However, maximum yield was recorded with the application of five irrigation at CRI+ jointing+ booting+ flowering+ milking stage (I4). Among herbicidal treatments, lowest density, fresh and dry weight of C. rotundus with  the highest WCE resulted in higher  yield of wheat was recorded with the application of carfentrazone ethyl 20% + sulfosulfuron 25%WG as post emergence (35 DAS) at 100 g/ha as compared to other treatments. However, none of the herbicidal treatments as effective as hand weeding twice at 20 and 40 DAS.
Impact of Phenophase Wise Climatic Parameters on Growth and Fruit Yield of Autumn Tomato (Solanum lycopersicum L.)
Authors: Shravika L. , Sreenivas G. , Madhavi A. , Rao A. Manohar
Published: October 2021

A field experiment was conducted during kharif season 2019to study and identify the impact of weather on growth and fruit yield of tomato under open field Crop was planted on eight different dates viz., 02 Jul, 12 Jul, 22 Jul, 02 Aug, 11 Aug, 23 Aug, 03 Sep and 13 Sep as main plots and two cultivars viz., US 440 and TO-3251 (Saaho) as sub-plots in split plot design and replicated thrice. Result revealed that, significantly more yield attributes and fruit yield of tomato was recorded with maximum temperature range of 30.7 to 32.8oC during vegetative phase, morning Relative humidity (RH) of 88 to 92% during fruit development phase, Vapour Pressure Defficient (VPD) of 0.6 to 0.7 kPa and 0.4 to 0.6kPa during fruit development and harvest phase. Further correlation studies revealed that the most critical weather parameter from fruit initiation to first picking stage was morning RH as this was negatively correlated with drymatter production at fruit development (-0.93**), harvest (-0.95**) and total fruit yield (-0.91**) of tomato, which accounted for 86%, 89% and 83% variation in drymatter production during fruit development, harvest phase and total fruit yield respectively.
Response of Gas Exchange Activity and Relative Water Content of Neem in Relation to Weather
Authors: Pugazenthi K. , Geethalakshmi V. , Senthil A. , Kumaran K. , Kanna S. Umesh
Published: October 2021

Neem is known for its medicinal values and is a hardy plant that can grow in a wide variety of environmental conditions. However, productivity is impacted by unfavourable weather conditions due to different geographical locations. The present study was conducted to study the influence of prevailing weather conditions on certain physiological parameters deciding the reproductive ability of neem trees. The study was conducted in two different locations at different agro-climatic regions of Tamil Nadu, India. Gas exchange parameters like photosynthetic rate, stomatal conductance, transpiration rate and leaf temperature and relative water content during pre-flowering, flowering and post-flowering stages were measured and correlated with temperature, relative humidity, precipitation and wind speed observed from the corresponding location. In both locations, the neem trees recorded significantly higher values for these physiological parameters during the pre-flowering and fruiting stages compared to the flowering stage. The trees with higher Diameter and breast height (DBH) showed higher values for gas exchange parameters compared to the trees with lower DBH.
Perancangan Adjustable Handlebar untuk Sepeda Motor dengan Dua Sistem Pengaturan
Authors: Kristiawan David Oboe , Tanoto Yopi Yusuf , Siahaan Ian Hardianto , . Naldi
Published: October 2021

Kemudi sepeda motor merupakan bagian penting yang berfungsi untuk mengendalikan arah kendaraan. Bentuk dari kemudi sangat beragam, mulai dari yang mengedepankan estetika sampai kenyamanan. Untuk kenyamanan tentu berbeda-beda setiap pengendaranya, salah satu faktor yaitu tinggi badan pengendara. untuk menyesuaikan kemudi supaya setiap pengendara dapat mengendarai kendaraan-nya dengan nyaman, maka dirancanglah handlebar yang dapat disesuaikan bentuknya dengan mudah. Perancangan adjustable handlebar ini dimulai dengan mendesain mekanisme-mekanisme perubah sudut dan ketinggian yang bisa dilakukan adjus­table handlebar. Perancangan ini menghasilkan mekanisme perubahan sudut dengan rentang 30° dengan step sebesar 10° dan rentang ketinggian sebesar 10 cm. Pengaturan dapat dilakukan dengan mudah tanpa harus pergi ke bengkel, dan dapat dilakukan setiap saat. Sehingga adjustable handlebar ini memungkinkan untuk memberi kenyamanan untuk setiap pengendara-nya, meski pengendara memiliki postur tubuh yang berbeda-beda.