bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-temperature deposition 3D printing biotin-doped PLGA/β-TCP scaffold for repair of bone defects in osteonecrosis of femoral head
Authors: Xue Peng , Tan Xiaoxue , Xi Hongzhong , Chen Hao , He Shuai , Sun Guangquan , Gu Changyuan , Jiang Xiaohong , Du Bin , Liu Xin
Published: January 2024

The removal of necrotic bone and implantation of bone repair materials is an effective treatment for osteonecrosis of the femoral head (ONFH)-type bone defects, but there are currently no clinically applicable bone repair materials. In this study, a biotin-doped bone repair scaffold was created using low-temperature deposition (LTD) three-dimensional (3D) printing technology, and its ability to repair bone defects in ONFH was evaluated. The scaffold was characterized in vitro, and its cytotoxicity and osteogenic capacity were assessed by co-culturing the scaffold with rat bone marrow mesenchymal stem cells. The scaffolds were implanted in an animal model of ONFH-type bone defects, and the effect of scaffolds on promoting bone repair was evaluated by means of radiology and histopathology. LTD 3D-printed biotin-doped scaffolds showed cancellous bone-like structures without inducing cytotoxicity, whereas high-biotin β-TCP scaffolds (HBPT; containing 2% biotin) promoted osteogenic differentiation more effectively. Experiments on animals revealed that the effect of HBPT on bone repair was significantly superior to that of other groups. The in vivo biocompatibility of HBPT was confirmed by blood analysis and hematoxylin and eosin staining of the main organs. In conclusion, biotin-doped scaffolds can be used to treat ONFH-type bone defects by virtue of their ability in promoting bone regeneration.
PENGARUH E-PAYMENT SERVICES DAN E-COMMERCE SERVICES TERHADAP KINERJA UMKM YANG DIMEDIASI OLEH DIGITALIZATION KNOWLEDGE “STUDI KASUS PADA UMKM FOOD AND BEVERAGE DI DAERAH ISTIMEWA YOGYAKARTA”
Authors: Andi Candra Yudas Tadius , Ahmad Pabulo Azfa Mutiara
Published: January 2024

The advancement of information technology and the COVID-19 pandemic has prompted Micro, Small, and Medium Enterprises (MSME) to shift towards e-payment and e-commerce services. This research aims to investigate the influence of E-Payment and E-Commerce services on the performance of MSME in the food and beverage sector in the Special Region of Yogyakarta, with digital knowledge as a mediator. The study employs the quantitative analysis method of Partial Least Square (PLS) involving 255 MSME. The results reveal that E-Payment services do not significantly impact MSME performance, while E-Commerce services have a significantly positive effect. Digital knowledge mediates the positive relationship between E-Payment and E-Commerce services and MSME performance. The implication is that MSME needs to consider more integrated strategies in adopting technology in this digital era to enhance their performance.
PENGARUH SERVANT LEADERSHIP, MOTIVASI KERJA, DAN LINGKUNGAN KERJA TERHADAP KEPUASAN KERJA PADA PEGAWAI SEKRETARIAT DPRD DIY
Authors: Nugroho Rahmanda Angger , Subiyanto Didik , Kusuma Nala Tri
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh servant leadership, motivasi kerja, dan lingkungan kerja pada pegawai Sekretariat DPRD DIY. Penelitian ini menggunakan metode kuantitatif, dan populasinya adalah seluruh pegawai Sekretariat DPRD DIY. Teknik pengambilan sampel menggunakan sampel jenuh pengumpulan data dilakukan dengan cara observasi dan kuesioner. Hasil penelitian menunjukkan bahwa servant leadership berpengaruh positif dan tidak signifikan terhadap kepuasan kerja, motivasi kerja berpengaruh positif dan signifikan terhadap kepuasan kerja, dan lingkungan kerja berpengaruh positif dan signifikan terhadap kepuasan kerja. Implikasi dalam penelitian ini yaitu hasil penelitian diharapkan dapat menjadi salah satu pengambilan kebijakan bagi pemimpin untuk meningkatkan servant leadership di dalam organisasi, sehingga karyawan akan merasa nyaman didalam organisasi memiliki kepuasan dalam bekerja dan mengurangi tingkat turnover intention pada pegawai.Kata Kunci: Servant leadership, Motivasi kerja, Lingkungan kerja, Kepuasan kerja
THE INFLUENCE OF GROWTH OPPORTUNITIES, CAPITAL STRUCTURE, PROFITABILITY, AND DIVIDEND POLICY ON FIRM VALUE (In Pharmaceutical Companies Listed on the Indonesia Stock Exchange 2014-2022)
Authors: Marsiati Lilin , Sari Pristin Prima , Kusumawardhani Ratih
Published: January 2024

This research aims to see the influence of growth opportunities, capital structure, profitability and dividend policy on company value. The type and source of research data is quantitative data using financial reports on pharmaceutical companies listed on the IDX for 2014-2022, while the sampling technique uses purposive sampling to obtain 9 pharmaceutical companies that meet the criteria. The method used in this research is multiple linear regression analysis, using the SPSS program to test it. The results show that partially growth opportunities (PER) and profitability (ROA) have a positive and significant effect on company value. Capital Structure (DER) has a negative but significant effect on company value. Dividend Policy (DPR) has a negative and insignificant effect on company value. Meanwhile, simultaneously the results of the F test and the coefficient of determination test show that X1, X2, X3, and X4 have a simultaneous effect on Y.
Austria
Authors: Rametsteiner Ewald , Aldrian Anton , Bauer Anja , Eberl Winfried , Sekot Walter , Wagner Susanne , Weiss Gerhard
Published: January 2024

In Austria, per capita consumption of wood products is comparatively high and has increased considerably during the last decades. One reason is the high apparent consumption of wood by Austrian intermediary products producers. It is also an effect of an increasingly wood friendly culture in wood construction, a society that has overall positive attitude to wood as a material, amongst others. Consumption of wood products is to some parts dependent on the image of these products in the eyes of consumers, especially vis-à-vis substitution products. Here, the shift to urban societies, technological developments and competitive behaviour of substitute producers have for some time left wood with a not-so-favourable image of being old-fashioned. Recent PR campaigns have successfully tackled this problem. The fact that Austria has a diverse landscape ranging from plains to high alpine regions creates a wide range of recreational, environmental and protective services. However, these are generally not exploited on a commercial basis but embedded in legal and customary rights and often provided by the state.
Germany
Authors: Mantau Udo , Schraml Ulrich , Kastenholz Edgar , Brogt Thomas
Published: January 2024

Entrepreneurship in non-industrial commercial timber production: The number on forest owners in Germany varies between different authors from less then one million to one and a half million forest owners because the number of owners with less then one acre is enormous and can hardly be estimated. About one third of the forest area belongs to small forest owners, about a half of which is managed by agricultural businesses. Aside from forest-related income, most of the businesses receive income in varying amounts from other sources. Services have therein a growing share. By far, the income from the forest is realised through the sale of wood. For the most part, the owners of smaller areas have predominantly more or less urban life-styles and are not to be regarded as "entrepreneurs." The privatisation of forest areas in Eastern Germany and the increasing sale of forest in the western part of the country have caused the number of owners with idealistic interests and without their own managerial competence to increase. Data on forest management and business success are almost exclusively submitted by farm foresters. They are in possession of relatively high stocks of coniferous wood, which have a high potential for use. A mobilisation of these quantities of wood has for a long time only limitedly succeeded in the larger businesses. The development of forest co-operatives also proceeds satisfactorily, above all with a high degree of participation of farmer forest owners, i.e. a high degree of government involvement.
Streamflow Characteristics of Two Forested Catchments in the Sopron Hills
Authors: Gribovszki Zoltán , Kalicz Péter , Kucsara Mihály
Published: January 2024

One of the central issues in hydrology is today to establish a relationship between the hydrological and biological processes in ecosystems. One question of this theme is the vegetation impact on the water budget of the catchment. Water use by vegetation can closely be linked to streamflow patterns on a variety of time scales. At present many details of these connections are poorly understood. Investigation on small catchments is the best way of studying hydrological processes in headwater, forested watersheds. In this paper drainage basin morphology and streamflow characteristics (base flow and quick flow) have been analysed under conditions of forest management in two neighbouring small forested catchments (the Farkas Valley and Vadkan Valley located in the prealpine hills bordering to Austria) on the basis of streamflow data collected during 2001.
Incidence, Aetiology and Pattern of Maxillofacial Injuries in a Tertiary Trauma Hospital, Nepal: A 5-year Retrospective Study
Authors: Maharjan Mahendra , R. Sakya Pranay , Gurung Juna , Rai Ashok , Tandukar Anjali
Published: January 2024

Introduction: The aim of the present study was to evaluate the incidence, aetiology and patterns of maxillofacial injuries in a tertiary trauma hospital in Nepal.

Methods: A retrospective analysis of all the maxillofacial trauma patients operated at the Department of Plastic, Cosmetic and Maxillofacial Surgery, B and B Hospital, Lalitpur, Nepal between 1st March, 2015 and 31st December, 2020 was performed. Data were collected for each patient in regards to age, gender, cause and nature and type of the injury and the treatment provided.

Results: Among 409 patients operated in this period for maxillofacial injuries, 83% (n=356) were male and 17% (n=73) were female. Patients in the second and third decade of life were found to be more prone to sustain maxillofacial injuries. Road traffic accident was the most frequent cause (n=331; 77%) followed by physical assault (n=46; 10.7%) and falls (n=42; 9.7%). Mandible was the most commonly fractured bone (n=125; 26.5%). Fracture of parasymphysis, combined symphysis and condyle fracture and parasymphysis and angle fracture were the most common patterns of mandible fracture.

Conclusions: The major cause of maxillofacial injuries among patients operated in our hospital was road traffic accident which directly reflects the poor traffic system and improperly planned roads.
Cooking Up Prosperity: Pop-Up Restaurants, Innovation, and Lifestyle Entrepreneurship
Authors: Kristin Nytun Leirdal Eli , Kwiatkowski Grzegorz , Dragin-Jensen Christian
Published: January 2024

Entrepreneurship is central to diversifying and enhancing the competitiveness of tourism offerings. The current literature underscores a critical oversight in nurturing entrepreneurship for tourism innovation and urges further exploration of entrepreneurial motivations in tourism start-ups.
This is particularly relevant because the tourism sector heavily relies on new ventures to drive innovation, as established firms often struggle to meet the growing demand for distinctive and unique travel experiences. This study examines the entrepreneurial journey and innovation process
within the tourism scene. Through comprehensive desk research and an in-depth entrepreneur interview, we aim to deepen our insights into the motivations driving entrepreneurs and the innovation processes behind their tourism products and services. Specifically, our research focuses on pop-up
restaurants, illuminating their embodiment of innovation and lifestyle entrepreneurship. The findings reveal that a sense of freedom, creativity, and the pursuit of uniqueness stand out as key motivational factors of establishing pop-up restaurants. These motivations extend into a continuous
business innovation cycle, as the drive to enhance and offer novel experiences remains paramount. This study elucidates the uncharted territory of tourism entrepreneurship and offers valuable insights into the driving forces and innovative dynamics within this evolving market.
Prevalence of Menstrual Cycle Disorders in Injectable Contraceptive Acceptors: Study at Mulya Mekar Health Center, Purwakarta Regency, Indonesia
Authors: Lusianawati Evalina Fransisca
Published: January 2024

Injection contraception is a hormonal contraceptive method that is widely used by women in Indonesia. This method has the advantages of high effectiveness and ease of use. However, contraceptive injections can also cause side effects, one of which is menstrual cycle disorders. This study aims to determine the prevalence of injection contraceptive acceptors on the menstrual cycle at the Mulya Mekar Health Center, Purwakarta Regency, Indonesia. This research uses a descriptive observational research design with accidental sampling. The research sample was 50 contraceptive injection acceptors aged 15-49 years. Data was collected using a questionnaire. The research results show that the prevalence of injection contraceptive acceptors who experience menstrual cycle disorders is 60%. The most frequently experienced menstrual cycle disorders are longer menstrual cycles (26%), followed by shorter menstrual cycles (24%), and irregular menstrual cycles (10%). This study concludes that the prevalence of menstrual cycle disorders in recipients of contraceptive injections is quite high. Therefore, it is important for acceptors to know the risks and benefits of this contraceptive method.
Talent Management Strategies and Service Delivery in County Governments in Kenya
Authors: Roba Boru Hussein , Wachira Anita , Mwenda Lilian
Published: January 2024

A proactive human resource management (HRM) system in public sector organizations is critical for effective public service delivery. However, sub-national(county) governments (SNGs) in Kenya faced significant challenges in acquiring and retaining talented staff because of a labour supply and demand mismatch. Based on the challenge, the study evaluated the nature of the talent management strategies and their influence on service delivery in sub-national governments in Kenya. The study utilized the descriptive design and critically examined the HRM structures by sampling 140 respondents (47 county secretaries, 47 county directors of HRM and 46 municipality managers from municipalities based at the county headquarters of 46 counties) through interviews and questionnaires. The respondents were chosen based on their functional human resource management roles in the counties. The research instrument was validated through a panel review and piloted in three counties. The qualitative reports support the establishment and strengthening of county HR structure and systems, building staff capacity through training, and adopting talent management policies and practices to reduce staff turnover. This process would optimize staff competencies in sustaining service provisions at the county level. The correlation analysis indicated that service delivery positively correlated with talent management strategies (r = 0.6731, p< 0.05) at 0.05 significance levels, while the regression analysis revealed that talent management strategies explain about 45.30 % variance in service delivery with an effect size (β1 = 0.6210 (t = 10.6, p < 0.05). Based on the findings, the study concluded that talent management strategies are crucial to improving service delivery in Kenya's sub-national(county) governments. The study recommends proactive planning and adequately structuring the county's workforce based on knowledge, skills, abilities, and other characteristics. The study suggests that county governance structures should integrate and concretize the HRM initiatives geared towards talent management
From the late Silla to the Goryeo Dynasty Stone Pagoda characteristic and Significance in Cheongyang region
Authors:   The Bukak Historical Society, Lee Seo-hyun
Published: January 2024

Buddhist stone art in the Cheongyang region remains in relatively diverse types, including stone pedestals, stone pagodas, stone Buddhas, and stone lanterns. It is presumed that the stone pedestal at Janggoksa Temple was created in the late Silla Dynasty, the earliest period, and most other stone art was created during the Goryeo Dynasty.
The art historical significance of Buddhist stone art in the Cheongyang region was examined in two major ways. First, the traditional style of Unified Silla is strongly reflected. The stone pedestal of Janggoksa Temple inherits the style of the square three-tiered Buddha statue pedestal of Silla, while showing new changes and inventions. In particular, it is significant in the history of Korean Buddhist art in that it is the only type of Buddhist pedestal that has a roof structure with pillars. The stone standing Buddha triad in Eupnae-ri, Cheongyang, also attracts attention as it strongly reflects the traditional style of the Unified Silla. The Chungcheongnam-do region is a place where temples were built by the royal family from the early days of the founding of the Goryeo Dynasty and stone art with a unique aesthetic of Goryeo, known as the Goryeo New Style, was created. This is significant in that it is almost the only one in the Chungcheongnam-do region, where Goryeo Silla Buddha statues were prevalent, that strongly follows the traditional style of Unified Silla.
Next, due to the geographical characteristic of Cheongyang being located in the center of Chungcheongnam-do, the influence relationship between the surrounding area and the stone pagoda style was identified. Lastly, it was confirmed that Chilgapsan Mountain is the center of Buddhist art in the Cheongyang region, as temples and Buddhist art, such as Janggoksa Temple, Dorimsaji Temple, and Jeonghyesa Temple, are concentrated in Chilgapsan Mountain.
A Study on the Royal Marriage in relation to the Political Situation from King Hyeonjong to the Early King Sukjong of the Joseon Dynasty
Authors:   The Bukak Historical Society, Shin Chae-yong
Published: January 2024

In the 17th century, the Joseon Dynasty was a period when “Sarim Politics” was implemented in which “Rustic literati[Sanlim]” check the royal authority by using academic standards. In particular, in the year of King Hyeon Jong, the political influence of the mountain party, such as Song Si yeol, after Gihae Ye-song, became stronger than that of the previous King Hyo jong, and the same Westerner, Handang, maternal relatives, and a few other men who sympathized with it united as a force to protect the royal authority. Moreover, King Hyeon jong was the only son of Hyojong. It was also during King Hyeon jong's year that the number of royal figures showed a significant decline from the previous period. Therefore, the spouses of King Hyeon jong's children were politically children of figures who followed Song Si-yeol, but the chosen figures had a relationship with Queen Hyojong's Inseon and Queen Myeongseong, compared to that of the time. It seems that King Hyeon jong and Queen Myeongseong sought to expand the royal power through their children's spouse's house, and later fostered them as a force to protect the royal authority
Novel Human Activity Recognition and Recommendation Models for Maintaining Good Health of Mobile Users
Authors: Zeng Xinyi , Huang Menghua , Zhang Haiyang , Ji Zhanlin , Ganchev Ivan
Published: January 2024

With the continuous improvement of the living standard, people have changed their concept from disease treatment to health management. However, most of the current health management software makes recommendations based on users’ static information, with low updating frequency. The effect of targeted suggestions becomes weak with time, and it is hard for the recommendation effect to be satisfactory. Based on the use of smartphones for recognizing human activities in real-time, firstly, a novel 'CNN+GRU' model is proposed in this paper, utilizing both convolutional neural networks (CNNs) and gated recurrent units (GRUs). 'CNN+GRU' can improve the recognition speed and extract the features in sensor data more accurately by achieving in the conducted experiments an average accuracy of 91.27%, thus outperforming other models compared. Secondly, another model, named SimilRec, is proposed for physical activity recommendation to users based on their health profile, the similarities between their current physical activity sequence, and the historical physical activity sequence of other (similar) users.
Szerkesztői előszó
Authors: Fazakas Gergely Tamás
Published: January 2024

Tematikus lapszámunk a 2023. június 15–16-án tartott debreceni tudományos konferencia anyagán alapul. Petőfi életműve és kultusza (Szövegek, városok, történetek, 1823–2023) címmel rendezett bicentenáriumi tanácskozásunkat a Déri Múzeum–Debreceni Irodalom Háza, a Debreceni Egyetem Magyar Irodalom- és Kultúratudományi Intézetének Magyar Emlékezethelyek Kutatócsoportja, valamint a Debreceni Református Kollégium Nagykönyvtára és Múzeuma készítette elő és rendezte meg, jelen lapszám szerkesztői, illetve Lakner Lajos irányításával – a fentieken túl a Nemzeti Kulturális Alap, a Debreceni Egyetem Bölcsészettudományi Kara, a Tiszántúli Református Egyházkerület, valamint Debrecen Megyei Jogú Város Önkormányzata támogatásával.
„Szegény Sándor! Szegény Sándor!” Petőfi emlékezete Arany János Emlények (1851–1855) című versciklusában
Authors: Owaimer Oliver
Published: January 2024

Petőfi not only became (remained) an extremely popular figure in the literary, journalistic, and critical discourses of the 1850s, but his figure and literary heritage – in addition to national pantheonization and widespread popularization – also became a competition for the appropriation of competing memory constructions and commemorative communities. The dilemma arises: how could personal grief be given a public voice in this communication dumping? Were the media, discursive and genre frameworks of the era at all suitable for the literary representation of the depths of grief? Or do media noise and public forms necessarily empty private dimensions? If we ask these questions, perhaps the seemingly suffocating atmosphere of Hungary in the middle of the 19th century does not seem so distant and foreign.
Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues
Authors: Kolyvanov G. B. , Litvin A. A. , Bochkov P. O. , Kravtsova O. Yu. , Gribakina O. G. , Povarnina P. Yu. , Zherdev V. P.
Published: January 2024

Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues. The aim is to study the tissue availability of a new original compound GK-2 in rats after its intraperitoneal administration. Methods. Quantitative determination of GK-2 in blood plasma and organ/tissue homogenates of rats was carried out by high-performance liquid chromatography with mass spectrometric detection. Results. The distribution of GK-2 in organs and tissues with varying degrees of vascularization was studied in rats. It was found that after a single intraperitoneal injection of GK-2 at a dose of 150 mg/kg, the studied compound was recorded in blood plasma for 2 hours, its half-life (t1/2el) was 0.4 hours. In organs and tissues, GK-2 was detected from 1.5 to 2 hours. The tissue availability of GK-2 in the liver — blood plasma system was 18.68; "kidneys — blood plasma" — 1.26; "spleen — blood plasma" — 0.68; "skeletal muscles — blood plasma" — 0.31. For the target organ, the brain, the tissue availability was 0.24. In the brain, the time to reach the maximum concentration of GK-2 (0.77 mcg/g) was 0.34 hours. It was found that GK-2 is excreted more slowly from the brain (t1/2el was 0.75 h) than from other organs and tissues (from 0.31 h for the spleen and up to 0.47 h for the kidneys).
Evaluation of the multiple doses thiozonide’s pharmacokinetics in patients diagnosed with pulmonary tuberculosis with multidrug-resistant or extensively drug-resistant Mycobacterium tuberculosis
Authors: Savchenko А. Yu. , Kukes V. G. , Burenkov M. S. , Ramenskaya G. V.
Published: January 2024

Relevance. The increase in the number of cases of multidrug-resistant tuberculosis (MDR-TB) determines the relevance of the development of new anti-TB drugs (ATDs). Determining the pharmacokinetics of a drug in the context of MDR-TB therapy is an integral part of the study of the original drug. Objective. Evaluation of the pharmacokinetic properties of a new original drug, thiozonide, in patients with MDR-TB with multiple doses of the drug. Methods. Thiozonide was used in patients with a verified diagnosis of MDR-TB as part of a clinical trial according to protocol No. THIO22 "Multicenter 12-week doubleblind, randomized, placebo-controlled clinical trial on the selection of optimal dosages of the drug thiozonide, capsules (CJSC Pharm-Sintez") for against the background of standard anti-tuberculosis chemotherapy in patients diagnosed with pulmonary tuberculosis with multidrug-resistant or extensively drugresistant Mycobacterium tuberculosis” (permission of the Ministry of Health of the Russian Federation No. 661 dated 11/24/2014). Results. The pharmacokinetic characteristics of thiozonide were determined during its repeated use in patients diagnosed with pulmonary tuberculosis with multidrug-resistant or extensively drug-resistant mycobacterium tuberculosis, receiving standard anti-tuberculosis chemotherapy, by HPLC with mass spectrometric detection. The time to reach the maximum concentration T max of thiozonide with repeated administration at a dose of 200 mg, 400 mg and 600 mg was 4.21 ± 1.23 hours, 4.9 ± 1.08 and 5.29 ± 0.91, respectively; the half-life T1/2 for the same dosages of the drug was 7.84 ± 1.86, 7.56 ± 1.92 and 6.3 ± 2.12 hours, respectively. The maximum concentration of thiozonide after taking the drug thiozoinide by volunteers was Cmax was observed at the level of 1386.89 ± 533.68 ng / ml in the group taking 200 mg of thiozonide per day, 2684.48 ± 712.40 when taking the drug at a dosage of 400 mg and 5558, 99 ± 2143.81 – at a dosage of 600 mg. Conclusion. A linear dependence of the maximum concentration and the area under the pharmacokinetic curve on the dose taken and also the average concentration of thiozonide in the blood plasma of patients with pulmonary tuberculosis with multidrug resistance of the causative agent of the disease was revealed.
Determination of the composition of pharmaceutical substances used in drugs with antiarrhythmic activity
Authors: Rogov A. V. , Mokrov G. V.
Published: January 2024

Cardiac arrhythmias are the most common pathologies of the cardiovascular system. Allapinin® and Allaforte® from “Pharmcenter VILAR” are effective IC-class antiarrhythmic agents. The main component of these drugs is a pharmaceutical substance with INN: lappaconitine hydrobromide, which in addition to lappaconitine hydrobromide itself, contains impurities of other diterpene alkaloids. This work is devoted to a detailed analysis of the alkaloid composition of a new pharmaceutical substance isolated from roots and rhizomes, as well as from the aerial part of plants of the genus Aconite (monkshood, wolfsbane) of the Ranunculaceae family (buttercups) using chromato-mass spectrometry and NMR spectroscopy. In addition, an assessment was made of the quantitative ratios of alkaloids in several samples of pharmaceutical substances isolated from different batches of medicinal plant raw materials.
THE POSSIBILITIES OF PREDICTING THE DEVELOPMENT OF ANTIBIOTIC RESISTANCE IN THE PROVISION OF PRIMARY HEALTH CARE ON THE EXAMPLE OF HELICOBACTER PYLORI INFECTION
Authors: Kalugin Andrey Alexandrovich
Published: January 2024

The resistance of Helicobacter pylori to clarithromycin was studied and compared with the frequency of antibiotic use for other reasons in patients with gastroesophageal reflux disease. The resistance of Helicobacter pylori to clarithromycin in patients with gastroesophageal reflux disease was determined by detecting specific DNA loci T2182C, A2142G/C and A2143G and amounted to 24%. According to medical histories and outpatient patient records, clarithromycin was used in the examined patients in 25% of cases, which is comparable to the frequency of Helicobacter pylori resistance detected by the molecular method. Routine monitoring of the use of antibiotics in real clinical practice in patients of a certain service region, in the absence of the possibility of using other techniques, may be a surrogate way to predict the development of Helicobacter pylori resistance.
THE CHOICE OF METHODS OF ORTHOPEDIC TREATMENT AT AN APPOINTMENT WITH AN ORTHOPEDIC DENTIST FOR PEOPLE OF ECONOMICALLY ABLE-BODIED AGE
Authors: Ryabinin Alexander Viktorovich , Ivanov Nikita Olegovich , Sosulina Lyudmila Leonidovna , Moiseeva Marina Vladimirovna , Mitroshina Marina Sergeevna
Published: January 2024

The article presents data obtained on the basis of a prospective study in a dental clinic, concerning the use of certain types of orthopedic structures for defects in hard dental tissues in patients aged 25-44 years.
THE INFLUENCE OF SPORTS ON THE PSYCHOLOGICAL STATE OF A PERSON
Authors: Aivazova Elena Sergeevna , Gorchanyuk Yuriy Andreevich , Dorofeeva Elena Nikolaevna
Published: January 2024

In the proposed article, the authors considered the question of the influence of sports on the psychological state of a person. Attention is focused on the fact that physical education and sports can be considered as a means of combating stress. The provisions that convince that motor activity has a positive effect on physiological and mental processes are presented.
GREENHOUSE MICROCLIMATE MODELING
Authors: Sereda Sergey Nikolaevich
Published: January 2024

The paper presents data on observations of greenhouse microclimate parameters using the ZONT measuring complex. An assessment of the dynamics of changes in microclimate parameters is given. The effect of aeration of air in a greenhouse in the ventilation mode is shown. An empirical mathematical model of the greenhouse microclimate is proposed. The results of modeling the microclimate parameters in the MathCAD program are presented.
APPLICATION OF ARTIFICIAL INTELLIGENCE AND BIG DATA METHODS IN STRATEGIC PLANNING AND MANAGEMENT
Authors: Zavedeev Egor Vladimirovich , Bigaev Herman Vyacheslavovich
Published: January 2024

The article is devoted to the study of the advantages and disadvantages of using artificial intelligence and big data methods in strategic planning and management. The characteristics of the modern global and Russian market of artificial intelligence and big data are given. The issues of developing strategic planning and management are being updated through modern digitalization tools. A comparative analysis of planning and management in their traditional and innovative variations is carried out.
ASSESSMENT OF THE RISK OF BANKRUPTCY OF AGRICULTURAL INDUSTRIAL ORGANIZATIONS: RATIOS AND CRITERIA IN THE REPUBLIC OF BELARUS
Authors: Bychkov Nikolai Aleksandrovich , Khatkevich Galina Vladimirovna
Published: January 2024

Assessing the risk of bankruptcy of business entities is an important element of financial analysis. The indicators and criteria introduced from 1.10.2023 in the Republic of Belarus will make it possible to determine the degree of bankruptcy risk and take measures to ensure the financial stability of organizations, to choose the necessary procedure in the bankruptcy case.
ECONOMIC SECURITY OF PERSONAL FINANCE WHEN TRANSFERRING FUNDS
Authors: Карп Марина Викторовна , Гулькова Елена Леонидовна , Типалина Мария Валерьевна
Published: January 2024

Проанализированы статистические данные Министерства внутренних дел Российской Федерации и Банка России о мошеннических действиях при переводе денежных средств. Рассмотрено действующее законодательство по данному вопросу, а также законопроекты, направленные на сокращение мошеннических действий в сфере кредитования физических лиц, предложены мероприятия по дальнейшему совершенствованию законодательства.

The statistics of the Ministry of Internal Affairs of the Russian Federation and the Bank of Russia on fraudulent actions in the transfer of funds were analyzed. The current legislation on this issue was considered, as well as bills aimed at reducing fraudulent actions in the field of lending to individuals, measures were proposed to further improve the legislation.
ИДЕИ ГЕРМЕНЕВТИКИ В ПРОФЕССИОНАЛЬНОЙ ПОДГОТОВКЕ СОВРЕМЕННОГО ПЕДАГОГА
Authors: Закирова Альфия Фагаловна , Григорьева Елена Александровна
Published: January 2024

Материалы содержат обоснование перспективности реализации феноменолого-герменевтического подхода в профессиональной подготовке педагога. Изложены принципы практической реализации концепции педагогической герменевтики.
ON SOME DIFFICULTIES OF LEGAL TRANSLATION (BASED ON THE MATERIAL OF TRANSLATION OF LEGAL DOCUMENTS FOR THE PROVISION OF SERVICES)
Authors: Прохорова Екатерина Владимировна
Published: January 2024

В статье представлен анализ основных лингвистических и контекстуальных сложностей при юридическом переводе документов, связанных с оказанием услуг. Исследование также уделяет внимание вопросу о взаимосвязи между юридической терминологией и культурными аспектами языка, а также предложены возможные способы преодоления выявленных трудностей.

The article presents an analysis of the main linguistic and contextual difficulties in the legal translation of documents related to the provision of services. The study also focuses on the relationship between legal terminology and cultural aspects of language, and suggests possible ways to overcome the identified difficulties.
ЛИНГВОДИДАКТИЧЕСКАЯ КОМПЕТЕНЦИЯ ПРЕПОДАВАТЕЛЕЙ ИНОСТРАННОГО ЯЗЫКА В СВЕТЕ ТРЕБОВАНИЙ СОВРЕМЕННОЙ ОБРАЗОВАТЕЛЬНОЙ СРЕДЫ
Authors: Гаврилова Анна Вадимовна
Published: January 2024

В статье рассматриваются требования к профессиональной подготовке преподавателя иностранного языка в высшей школе в свете новой образовательной парадигмы. Особое внимание уделяется одной из составляющих профессиональных компетенций преподавателя - лингводидактической компетенции, ее структуре и роли каждого компонента в профессиональной деятельности педагога.
APPLICATION OF NEURAL NETWORKS IN RUSSIA
Authors: Смирнов Сергей Владимирович
Published: January 2024

Работа посвящена применению отечественных нейронных сетей в различных сферах. Представлена краткая история развития нейросетей. Рассмотрено применение следующих нейросетей: YandexGPT в интернет-поисковике Яндекс, SistemmaGPT (генератор текста), СППВР (система поддержки принятия врачебных решений), Vision Cyto Pap (визуализация и скрининг с целью выявления опухолей). Кроме того, было рассмотрено возможное применение НС «Зеркало» для МВД с целью выявления кибермошенничества. Изложены перспективы дальнейшего развития нейросетей.

The work is devoted to the application of domestic neural networks in various fields. A brief history of the development of neural networks is presented. The use of the following neural networks is considered: YandexGPT in the Yandex Internet search engine, SistemmaGPT (text generator), CPPVR (medical decision support system), Vision Cyto Pap (visualization and screening to detect tumors). In addition, the possible use of the National Security Service "Mirror" for the Ministry of Internal Affairs in order to identify cyberbullying was considered. The prospects for further development of neural networks are outlined.
КОМПЛЕКСНЫЙ ПОДХОД К РЕШЕНИЮ ТЕХНОЛОГИЧЕСКИХ ПРОБЛЕМ КАК ОСНОВА ЭКОНОМИЧЕСКОЙ ЭФФЕКТИВНОСТИ И УСТОЙЧИВОГО РАЗВИТИЯ САХАРНОГО ПОДКОМПЛЕКСА АПК
Authors: Клемешов Дмитрий Анатольевич , Бурлин Константин Владимирович
Published: January 2024

В статье приведено состояние в свеклоперерабатывающей отрасли РФ. Описана динамика изменений за последние десятилетия, позволяющих обеспечить население одним из основных источников углеводов. Приведены основные направления развития, которые заключаются в оптимизации существующих технологических процессов, которые позволят снизить себестоимость выпускаемой продукции. Приведены основные перспективные пути интенсификации. Предложен механизм перспективной практики взаимодействия основных представителей отрасли в форме технопарков, которые ускорят внедрение новых эффективных, высокомаржинальных технологий. Предлагаемый комплекс мер позволит обеспечить курс на устойчивое развитие и динамику для обеспечения технического превосходства и экономического развития в данной социально значимой отрасли.

The article describes the state of the beet processing industry in the Russian Federation. The dynamics of changes over the past decades, which make it possible to provide the population with one of the main sources of carbohydrates, is described. The main directions of development are given, which consist in optimizing existing technological processes that will reduce the cost of production. The main promising ways of intensification are given. The mechanism of promising practice of interaction between the main representatives of the industry in the form of technoparks, which will accelerate the introduction of new effective, high-margin technologies, is proposed. The proposed set of measures will ensure a course towards sustainable development and dynamics to ensure technical superiority in this socially significant industry.
THE INFLUENCE OF LIFESTYLE AND NUTRITION ON THE DEVELOPMENT OF OBESITY IN CHILDREN: ANALYSIS OF RISK FACTORS AND THE PROPOSAL OF EFFECTIVE PREVENTION STRATEGIES
Authors: Гарифьянова Амина Эльвировна , Исламов Альфир Рафилевич , Галиуллин Тимур Рустамович , Гибадуллина Фируза Булатовна
Published: January 2024

В статье ставится задача исследовать влияние образа жизни и питания на развитие ожирения у детей. В работе проведен анализ факторов риска, предрасполагающих к возникновению ожирения у детей, а также предложены эффективные стратегии профилактики данного заболевания.

The article aims to investigate the influence of lifestyle and nutrition on the development of obesity in children. The paper analyzes the risk factors predisposing to the occurrence of obesity in children and suggests effective strategies for the prevention of this disease.
FEATURES OF PARENTAL RELATIONSHIPS IN FAMILIES WITH CHILDREN WITH DISORDERS AUTISTIC SPECTRUM
Authors: Сальникова Екатерина Петровна
Published: January 2024

Представлены результаты исследования, направленного на выявление особенностей родительских отношений в семьях, имеющих детей с расстройствами аутистического спектра. Выявлено, что в семьях, имеющих детей с проблемами в развитии, в частности с расстройствами аутистического спектра, часто наблюдаются неправильные формы поведения, которые препятствуют нормальной социализации детей.

The results of a study aimed at identifying the characteristics of parental relationships in families with children with autism spectrum disorders are presented. It has been revealed that in families with children with developmental problems, in particular with autism spectrum disorders, abnormal forms of behavior are often observed that interfere with the normal socialization of children.
Information distribution patterns in naturalistic dialogue differ across languages
Authors: Trujillo James P. , Holler Judith
Published: January 2024

The natural ecology of language is conversation, with individuals taking turns speaking to communicate in a back-and-forth fashion. Language in this context involves strings of words that a listener must process while simultaneously planning their own next utterance. It would thus be highly advantageous if language users distributed information within an utterance in a way that may facilitate this processing–planning dynamic. While some studies have investigated how information is distributed at the level of single words or clauses, or in written language, little is known about how information is distributed within spoken utterances produced during naturalistic conversation. It also is not known how information distribution patterns of spoken utterances may differ across languages. We used a set of matched corpora (CallHome) containing 898 telephone conversations conducted in six different languages (Arabic, English, German, Japanese, Mandarin, and Spanish), analyzing more than 58,000 utterances, to assess whether there is evidence of distinct patterns of information distributions at the utterance level, and whether these patterns are similar or differed across the languages. We found that English, Spanish, and Mandarin typically show a back-loaded distribution, with higher information (i.e., surprisal) in the last half of utterances compared with the first half, while Arabic, German, and Japanese showed front-loaded distributions, with higher information in the first half compared with the last half. Additional analyses suggest that these patterns may be related to word order and rate of noun and verb usage. We additionally found that back-loaded languages have longer turn transition times (i.e., time between speaker turns).
Yönetim Kuramları ile Güncel Siyasete : Okul ve Girişimcilik Perspektifinden Bakış
Authors: Yılmaz Cumali , Yılmaz Deniz
Published: January 2024

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Inclusive Management of Our Water Commons
Authors: Mahajan Rashmi , Rajankar Manish
Published: January 2024

In the past 75 years, since Independence, the central and state governments in India have implemented various measures for water management, which include initiatives to construct and revive small water bodies and wetlands. Schemes such as Amrit Sarovar, Amrit Dharohar, Jalyukta Shivar, and Galmukta Dharan-Galyukt Shivar are being implemented to revive small water bodies. However, these schemes have been criticised for their unsystematic planning and implementation and for benefiting an elite section of society while excluding people experiencing poverty. India is known for its traditional water harvesting systems and community-based management of water commons. Through a case study of grassroots-level management of small-scale waterbodies in eastern Maharashtra, this paper demonstrates the need to understand local dynamics and ground realities for inclusive and efficient water management.
Indeks Kebugaran Siswa Kelas V Sekolah Dasar Negeri 96 Kota Utara Kota Gorontalo
Authors: Said Hariadi
Published: January 2024

Anak usia sekolah adalah investasi bangsa, karena mereka adalah generasi penerus bangsa. Tumbuh berkembangnya anak usia sekolah tergantung lingkungan yang membentuknya. Salah satu lingkungan yang sangat berperan dalam perkembangan anak adalah sekolah dasar (SD). Hal ini dikarenakan SD dapat menjadi lingkungan yang sangat tepat untuk membentuk generasi penerus bangsa yang sehat, aktif, dan berintegritas melalui kegiatan olahraga.Tujuan penelitian untuk mengetahui indeks kebugaran siswa kelas V SD N 96 Kota Utara Kota Gorontalo. Metode penelitian yang digunakan adalah metode observasi lapangan. Populasi penelitian adalah seluruh siswa kelas V SD N 96 Kota Utara Kota Gorontalo yang berjumlah 19 orang terdiri dari 11 laki-laki dan 8 perempuan. Bentuk tes yang dipergunakan dalam penelitian ini adalah bleep test yaitu lari hilir mudik antara dua titik yang berjarak 20 meter dengan iringan musik. Hasil penelitian menunjukkan bahwa Kelompok laki-laki sebanyak 11 orang atau 100% semuanya berada dalam kategori kurang sekali. Kelompok perempuan yang berjumlah  8 orang atau 100% berada pada kategori kurang sekali. Berdasarkan hasil tersebut dapat disimpulkan bahwa indeks kebugaran siswa kelas V SDN 96 Kota Utara Kota Gorontalo berada pada kategori kurang sekali sehingga perlu perhatian yang serius.
Conflicts of competence of the indigenous jurisdiction vis-à-vis the ordinary jurisdiction
Authors: Supe Guashco Jessica Diana , Jaramillo León Alexandra Anabel
Published: January 2024

The ordinary jurisdiction is governed by the common laws of law, while the indigenous jurisdiction is governed by the customary law of the traditions, customs and culture of indigenous peoples, communities and nationalities; and, it is from the application of this legal pluralism recognized by Art. 1 of the Constitution of the Republic of Ecuador, where conflicts of jurisdiction arise between these two jurisdictions, because there is no law regulating the coordination and cooperation between the ordinary and indigenous jurisdiction. For this reason, the main objective of the research is to analyze the conflicts of competence generated in the applicability of the indigenous jurisdiction vis-à-vis the ordinary jurisdiction. The methodology is based on a qualitative approach, which is carried out through the use of the bibliographic-documentary method, which is carried out through the analysis based on books, pamphlets, articles and other documentary materials that allow developing a deep investigation based on the collection of information of bibliographic and documentary indoles of great relevance to expand knowledge. This allows concluding that at present the indigenous jurisdiction is managed as an isolated world trying to regulate the coexistence of peace and harmony in its territory, and that the ordinary jurisdiction observes the pronouncements of the National Court of Justice or Constitutional Court of Ecuador, to be able to act in analogous cases, making use of the sources of law that these provisions emanate.
Efficacy and Safety of Omarigliptin, a Novel Once-Weekly Dipeptidyl Peptidase-4 Inhibitor, in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Kamrul-Hasan A.B.M. , Alam Muhammad Shah , Talukder Samir Kumar , Dutta Deep , Selim Shahjada
Published: January 2024

Background: No recent meta-analysis has holistically analyzed and summarized the efficacy and safety of omarigliptin in type 2 diabetes mellitus (T2DM). We conducted a meta-analysis to address this knowledge gap.Methods: Electronic databases were searched to identify randomized controlled trials (RCTs) that included patients with T2DM who received omarigliptin in the intervention arm. The control arm consisted of either a placebo (passive control group [PCG]) or an active comparator (active control group [ACG]). The primary outcome assessed was changes in hemoglobin A1c (HbA1c), while secondary outcomes included variations in glucose levels, achievement of glycemic targets, adverse events (AEs), and hypoglycemic events.Results: From 332 initially screened articles, data from 16 RCTs involving 8,804 subjects were analyzed. Omarigliptin demonstrated superiority over placebo in reducing HbA1c levels (mean difference, –0.58%; 95% confidence interval, –0.75 to –0.40; P<0.00001; I2=91%). Additionally, omarigliptin outperformed placebo in lowering fasting plasma glucose, 2-hour postprandial glucose, and in the percentage of participants achieving HbA1c levels below 7.0% and 6.5%. The glycemic efficacy of omarigliptin was similar to that of the ACG across all measures. Although the omarigliptin group experienced a higher incidence of hypoglycemic events compared to the PCG, the overall AEs, serious AEs, hypoglycemia, and severe hypoglycemia were comparable between the omarigliptin and control groups (PCG and ACG).Conclusion: Omarigliptin has a favorable glycemic efficacy and safety profile for managing T2DM.
Early Modern Archives 1560–1640
Authors: Olney Richard
Published: January 2024

This chapter portrays the period 1560 – 1640 as a relatively peaceful one, during which many archives gained in depth and substance, and standards of record-keeping gradually improved. In central government advances were made in both Westminster and Whitehall. Elsewhere the archives of the Church of England began to acquire a greater range and solidity, and even county records were on average better kept. Estate archives and business records embraced new types of document – deed registers, ledgers, minute books and so on. The chapter ends with a discussion of two distinctive phenomena of the period – the fashion for letter-writing and the expansion of the personal archive; and the rise of the antiquaries and their role in the preservation of records that would otherwise have been lost.