bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Safety and Efficacy of Therapeutic Hypothermia in Pediatric Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis
Authors: Naseri Alavi Seyed Ahmd , Habibi Mohammad Amin , Majdi Alireza , Hajikarimloo Bardia , Rashidi Farhang , Fathi Tavani Sahar , Minaee Poriya , Eazi Seyed Mohammad , Kobets Andrew J.
Published: June 2024

Background: Prior guidelines recommended maintaining normothermia following traumatic brain injury (TBI), but recent studies suggest therapeutic hypothermia as a viable option in pediatric cases. However, some others demonstrated a higher mortality rate. Hence, the impact of hypothermia on neurological symptoms and overall survival remains contentious. Methods: We conducted a systematic review and meta-analysis to evaluate the effects of hypothermia on neurological outcomes in pediatric TBI patients. The PubMed/Medline, Scopus, and Web of Science databases were searched until 1 January 2024 and data were analyzed using appropriate statistical methods. Results: A total of eight studies, comprising nine reports, were included in this analysis. Our meta-analysis did not reveal significant differences in mortality (RR = 1.58; 95% CI = 0.89–2.82, p = 0.055), infection (RR = 0.95: 95% CI = 0.79–1.1, p = 0.6), arrhythmia (RR = 2.85: 95% CI = 0.88–9.2, p = 0.08), hypotension (RR = 1.54: 95% CI = 0.91–2.6, p = 0.10), intracranial pressure (SMD = 5.07: 95% CI = −4.6–14.8, p = 0.30), hospital length of stay (SMD = 0.10; 95% CI = −0.13–0.3, p = 0.39), pediatric intensive care unit length of stay (SMD = 0.04; 95% CI = −0.19–0.28, p = 0.71), hemorrhage (RR = 0.86; 95% CI = 0.34–2.13, p = 0.75), cerebral perfusion pressure (SMD = 0.158: 95% CI = 0.11–0.13, p = 0.172), prothrombin time (SMD = 0.425; 95% CI = −0.037–0.886, p = 0.07), and partial thromboplastin time (SMD = 0.386; 95% CI = −0.074–0.847, p = 0.10) between the hypothermic and non-hypothermic groups. However, the heart rate was significantly lower in the hypothermic group (−1.523 SMD = −1.523: 95% CI = −1.81–−1.22 p < 0.001). Conclusions: Our findings challenge the effectiveness of therapeutic hypothermia in pediatric TBI cases. Despite expectations, it did not significantly improve key clinical outcomes. This prompts a critical re-evaluation of hypothermia’s role as a standard intervention in pediatric TBI treatment.
Safety and Tolerability of Continuous Inhaled Iloprost Therapy for Severe Pulmonary Hypertension in Neonates and Infants
Authors: Krishnan Amit V. , Freniere Victoria , Sahni Rakesh , Vargas Chaves Diana P. , Krishnan Sankaran S. , Savva Dimitrios , Krishnan Usha S.
Published: June 2024

This is a single-center retrospective study to assess the safety and tolerability of continuous inhaled iloprost use as rescue therapy for refractory pulmonary hypertension (PH) in critically ill neonates and infants. A retrospective chart review was performed on 58 infants and data were collected at baseline, 1, 6, 12, 24, 48 and 72 h of iloprost initiation. Primary outcomes were change in heart rate (HR), fraction of inspired oxygen (FiO2), mean airway pressures (MAP), blood pressure (BP) and oxygenation index (OI). Secondary outcomes were need for extracorporeal membrane oxygenation (ECMO) and death. 51 patients treated for >6 h were analyzed in 2 age groups, neonate (≤28 days: n = 32) and infant (29–365 days: n = 19). FiO2 (p < 0.001) and OI (p = 0.01) decreased, while there were no significant changes in MAP, BP and HR. Of the fifteen patients placed on ECMO, seven were bridged off ECMO on iloprost and eight died. Twenty-four out of fifty-one patients (47%) recovered without requiring ECMO, while twelve (23%) died. Iloprost as add-on therapy for refractory PH in critically ill infants in the NICU has an acceptable tolerability and safety profile. Large prospective multicenter studies using iloprost in the neonatal ICU are necessary to validate these results.
Impact of Zinc Oxide on the Development of Aspergillus-Induced Maxillary Sinusitis Rabbit Model
Authors: Shin Seung-Heon , Ye Mi-Kyung , Lee Dong-Won , Choi Mi-Hyun
Published: June 2024

Aspergillus fumigatus is commonly found in the airway and is associated with airway inflammatory diseases. Zinc oxide (ZO) is known to be an essential microelement that facilitates fungal survival, growth, and proliferation. This study aimed to investigate the impact of ZO on A. fumigatus-induced fungal sinusitis in rabbits. Twenty-eight New Zealand white rabbits were divided into four groups for this study. Group 1 (6 sides) was treated with intramaxillary phosphate buffer saline (PBS) served as the negative control, Group 2 (6 sides) received intramaxillary PBS and ZO, Group 3 (8 sides) was treated with intramaxillary A. fumigatus alone, and Group 4 (8 sides) treated with intramaxillary A. fumigatus with ZO. After 4 and 12 weeks, sinus mucosal cytokine and transcription factor expressions were determined. A histological analysis was performed to determine inflammatory cell infiltration, number of secretory cells, and mucosal thickness. Fungal biofilm formation was determined using confocal laser microscopy. The intramaxillary instillation of A. fumigatus conidia led to an increase in protein and mRNA expression of interleukin (IL)-1β and IL-8 in the maxillary sinus mucosa. They were associated with mitogen-activated protein kinase and activator protein-1. Furthermore, intramaxillary instillation of fungal conidia resulted in significant enhancement of inflammatory cell infiltration, epithelial thickening, and fungal biofilm formation. However, intramaxillary ZO did not have a significant impact on A. fumigatus-induced cytokine protein and mRNA expression, and inflammatory cell infiltration and epithelial thickness in sinonasal mucosa. While intramaxillary instillation of A. fumigatus increased mucosal inflammation, cytokine production, and biofilm formation, the intramaxillary application of ZO did not have a significant influence on inflammation in the maxillary sinus mucosa.
Decarbonising the EU Buildings|Model-Based Insights from European Countries
Authors: Fotiou Theofano , Fragkos Panagiotis , Zisarou Eleftheria
Published: June 2024

The European Union faces the pressing challenge of decarbonising the buildings sector to meet its climate neutrality goal by 2050. Buildings are significant contributors to greenhouse gas emissions, primarily through energy consumption for heating and cooling. This study uses the advanced PRIMES-BuiMo model to develop state-of-the-art innovative pathways and strategies to decarbonise the EU buildings sector, providing insights into energy consumption patterns, renovation rates and equipment replacement dynamics in the EU and in two representative Member States, Sweden and Greece. The model-based analysis shows that the EU’s transition towards climate neutrality requires significant investment in energy efficiency of buildings combined with decarbonisation of the fuel mix, mostly through the uptake of electric heat pumps replacing the use of fossil fuels. The Use Case also demonstrates that targeted policy interventions considering the national context and specificities are required to ensure an efficient and sustainable transition to zero-emission buildings. The analysis of transformational strategies in Greece and Sweden provides an improved understanding of the role of country-specific characteristics on policy effectiveness so as to inform more targeted and contextually appropriate approaches to decarbonise the buildings sector across the EU.
The Influence of Bias Voltage and Gas Pressure on Edge Covering during the Arc-PVD Deposition of Hard Coatings
Authors: Zimmer Otmar , Krülle Tim , Litterst Thomas
Published: June 2024

The edge area is especially essential for cutting tools, since this is the contact zone between the work piece and the tool. Hard coatings (PVD or CVD coatings) can protect the edge against wear and they are commonly used. The geometries of the cutting edges change during the coating process, with the edge radius increasing. Therefore, the film thickness is limited and the initial radius of the uncoated tool must be smaller than the target radius of the coated edge. A new coating process based on vacuum arc PVD was developed to overcome this limitation. The film growth at the edges can be properly controlled by means of selected coating materials and process conditions. Thus, it is possible to grow edges sharper than the initial edge geometry. Different substrates were coated with different coating systems. Parameters such as the bias voltage, coating pressure, and initial radius were varied within this work. It was found that the application of a bias voltage is crucial for the generation of sharp edges. It was also found that the edge sharpening caused by coatings works best on samples with an initial radius of around 15 µm.
Genetic Population Structure of Lane Snapper Lutjanus synagris (Linnaeus, 1758) in Western Atlantic: Implications for Conservation
Authors: Núñez-Vallecillo Mayra , Vera-Escalona Iván , Rivera Antonella , Górski Konrad , Brante Antonio
Published: June 2024

Genetic structure and connectivity information can be used to identify biological corridors and prioritize the conservation of areas that help maintain ecosystem integrity. Some marine fish, especially those of commercial interest, have been proposed as suitable indicators to identify potential marine biological corridors due to their high mobility among habitats and socioeconomic importance. In this study, we assessed the genetic structure of lane snapper populations in the Honduran Caribbean to evaluate connectivity and identify potential environmental barriers. Furthermore, we evaluated the genetic characteristics of the lane snapper on a larger spatial scale, including populations across the rest of its distribution range in the western Atlantic, using mtDNA and nuDNA markers. Our results demonstrate a significant genetic diversity of lane snappers in the Honduran Caribbean. Furthermore, despite their high dispersal potential, we observed genetic structuring in lane snapper populations on a larger spatial scale, resulting in the formation of two distinct groups throughout their distribution range: group 1 from Florida, the Gulf of Mexico, Honduras, and Colombia and group 2 from Puerto Rico and Brazil. This genetic differentiation can be attributed to oceanographic barriers such as river plumes and marine currents. These findings have the potential to significantly impact marine conservation and management efforts in the region, both at local and regional scales. It is anticipated that they will not only inform but also elicit a response, driving further action towards effective conservation measures. At a local scale, we recommend that conservation efforts focus on protecting critical habitats. At a regional scale, lane snappers should be included in the management plans of existing marine protected areas necessary to ensure the long-term sustainability of the species and the marine ecosystems in which it resides.
Development of Aptamers for RNase Inactivation in Xtract-Free™ Sample Collection and Transport Medium
Authors: Daum Luke T. , Rodriguez John D. , Chambers James P.
Published: June 2024

There is a significant need to develop new environmentally friendly, extraction-free sample collection mediums that can effectively preserve and protect genetic material for point-of-care and/or self-collection, home-collection, and mail-back testing. Systematic evolution of ligands by exponential enrichment (SELEX) was used to create anti-ribonuclease (RNase) deoxyribonucleic acid (DNA) aptamers against purified RNase A conjugated to paramagnetic carboxylated beads. Following eight rounds of SELEX carried out under various stringency conditions, e.g., selection using Xtract-Free™ (XF) specimen collection medium and elevated ambient temperature of 28 °C, a panel of five aptamers was chosen following bioinformatic analysis using next-generation sequencing. The efficacy of aptamer inactivation of RNase was assessed by monitoring ribonucleic acid (RNA) integrity via fluorometric and real-time RT-PCR analysis. Inclusion of aptamers in reaction incubations resulted in an 8800- to 11,200-fold reduction in RNase activity, i.e., digestion of viral RNA compared to control. Thus, anti-RNase aptamers integrated into XF collection medium as well as other commercial reagents and kits have great potential for ensuring quality intact RNA for subsequent genomic analyses.
Evaluating the Health-Related Quality of Life in Patients with COPD and Chronic Heart Failure Post-Hospitalization after COVID-19 Using the EQ-5D and KCCQ Questionnaires
Authors: Sukosd Ilona Emoke , Gadde Sai Teja , Pravallika Myneni , Pescariu Silvius Alexandru , Prodan Mihaela , Toma Ana-Olivia , Fericean Roxana Manuela , Hrubaru Ingrid , Sarau Oana Silvana , Fira-Mladinescu Ovidiu
Published: June 2024

Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) frequently coexist, significantly impacting health-related quality of life (HRQoL). This study evaluated HRQoL in patients with CHF, COPD, or both, three months post-COVID-19 discharge using EQ-5D and KCCQ questionnaires to guide targeted healthcare interventions. We conducted a cross-sectional study at “Victor Babes” Hospital in Timisoara, enrolling 180 patients who had recovered from COVID-19 (60 in each group including CHF, COPD, and both conditions). HRQoL was assessed via EQ-5D and KCCQ. Significant disparities in HRQoL measures were noted across the groups. Patients with both CHF and COPD reported the worst outcomes, especially in terms of hospital stay lengths due to COVID-19 (11.63 days) and initial oxygen saturation levels (88.7%). HRQoL improvements from discharge to three months post-discharge were significant, with EQ-5D mobility scores improving notably across all groups (CHF and COPD: 2.87 to 2.34, p = 0.010). KCCQ results reflected substantial enhancements in physical limitation (CHF and COPD: 38.94 to 58.54, p = 0.001) and quality of life scores (CHF and COPD: 41.38 to 61.92, p = 0.0031). Regression analysis revealed that dual diagnosis (CHF and COPD) significantly impacted usual activities and quality of life (β = −0.252, p = 0.048; β = −0.448, p = 0.017), whereas the initial severity of COVID-19 was a significant predictor of worse HRQoL outcomes (β = −0.298, p = 0.037; β = −0.342, p = 0.024). The presence of both CHF and COPD in patients recovering from COVID-19 was associated with more severe HRQoL impairment compared with either condition alone. These findings emphasize the need for specialized, comprehensive post-COVID-19 recovery programs that address the complex interplay among chronic conditions to optimize patient outcomes and enhance quality of life.
Sequential Learning of Flame Objects Sorted by Size for Early Fire Detection in Surveillance Videos
Authors: Samosir Widia A. , Nguyen Duy B. , Kong Seong G.
Published: June 2024

This paper presents a sequential learning method aimed at improving the performance of a lightweight deep learning model used for detecting fires at an early stage in surveillance video streams. The proposed approach involves a sequence of supervised learning steps, wherein the entire training dataset is partitioned into multiple sub-datasets based on the size of fire objects. The size of fire objects is measured by object size ratio, which is the ratio of the bounding box area of the detected fire flame object relative to the entire image area. The initial training sub-dataset contains the largest-sized fire objects, progressing to the final sub-dataset containing the smallest-sized fire objects. The objective is to employ sequential learning to enhance the detection of small-sized fire objects relative to the image area using a lightweight model suitable for edge computing devices. Experiment results demonstrate that a deep learning fire detection model trained sequentially with a descending order of object size can effectively detect small flame objects with an object size ratio less than 0.006, achieving an F1 score of 93.1%, representing a 27% improvement compared to traditional supervised learning with no sequential learning steps. Additionally, performance in detecting tiny flame objects with an object size ratio less than 0.0016 achieves an F1 score of 94.5%, showing a 17.5% increase compared to the baseline without sequential learning.
Research on the Gunn Oscillation Effect of GaN HEMT with Field Plate Structure in the Terahertz Frequency Band
Authors: Yuan Ruicong , Wu Jiamin , Wang Lin
Published: June 2024

Based on the enormous application potential of GaN-based high electron mobility transistors (HEMT) in high-frequency and high-power scenarios, this article focuses mainly on the study of the Gunn oscillation effect of GaN-based HEMT devices. From the perspective of electric field regulation, a sandwich structure GaN HEMT device model with field plate structure is proposed, and a hydrodynamic physical model is established. The negative resistance characteristics in the GaN HEMT are obtained by the finite element method and the influence of the gate field plate on the Gunn oscillation frequency in the device channel is studied. The numerical simulation results show that the suitable field plate structure can modulate the distribution of the channel electric field below the gate, promote the electric field to enter the negative differential mobility region, undergo valley to valley electron transfer, form electron domains, and generate the Gunn oscillation currents in the terahertz band. Meanwhile, the length of the field plate regulates the oscillation current frequency of the device, and the stable and usable terahertz frequency band signal can be realized. This research opens up the possibility for semiconductor solid-state devices to realize terahertz frequency band radiation, and provides the basis for realizing new breakthroughs in HEMT for terahertz applications.
Path Planning Techniques for Real-Time Multi-Robot Systems: A Systematic Review
Authors: AbuJabal Nour , Rabie Tamer , Baziyad Mohammed , Kamel Ibrahim , Almazrouei Khawla
Published: June 2024

A vast amount of research has been conducted on path planning over recent decades, driven by the complexity of achieving optimal solutions. This paper reviews multi-robot path planning approaches and presents the path planning algorithms for various types of robots. Multi-robot path planning approaches have been classified as deterministic approaches, artificial intelligence (AI)-based approaches, and hybrid approaches. Bio-inspired techniques are the most employed approaches, and artificial intelligence approaches have gained more attention recently. However, multi-robot systems suffer from well-known problems such as the number of robots in the system, energy efficiency, fault tolerance and robustness, and dynamic targets. Deploying systems with multiple interacting robots offers numerous advantages. The aim of this review paper is to provide a comprehensive assessment and an insightful look into various path planning techniques developed in multi-robot systems, in addition to highlighting the basic problems involved in this field. This will allow the reader to discover the research gaps that must be solved for a better path planning experience for multi-robot systems.
IFSrNet: Multi-Scale IFS Feature-Guided Registration Network Using Multispectral Image-to-Image Translation
Authors: Chen Bowei , Chen Li , Khalid Umara , Zhang Shuai
Published: June 2024

Multispectral image registration is the process of aligning the spatial regions of two images with different distributions. One of the main challenges it faces is to resolve the severe inconsistencies between the reference and target images. This paper presents a novel multispectral image registration network, Multi-scale Intuitionistic Fuzzy Set Feature-guided Registration Network (IFSrNet), to address multispectral image registration. IFSrNet generates pseudo-infrared images from visible images using Cycle Generative Adversarial Network (CycleGAN), which is equipped with a multi-head attention module. An end-to-end registration network encodes the input multispectral images with intuitionistic fuzzification, which employs an improved feature descriptor—Intuitionistic Fuzzy Set–Scale-Invariant Feature Transform (IFS-SIFT)—to guide its operation. The results of the image registration will be presented in a direct output. For this task we have also designed specialised loss functions. The results of the experiment demonstrate that IFSrNet outperforms existing registration methods in the Visible–IR dataset. IFSrNet has the potential to be employed as a novel image-to-image translation paradigm.
The Impact of Grid Distortion on the Power Conversion Harmonics of AC/DC Converters in the Supraharmonic Range
Authors: Osheba Marwa S. , Aboutaleb Abdellatif M. , Desmet Jan , Knockaert Jos
Published: June 2024

AC/DC converters, controlled by pulse width modulation (PWM) and used as power factor correction (PFC), is considered one of the main contributors to emissions in the range 2 kHz–150 kHz, recently known as the supraharmonic (SH) range. This study looks at the impact of SH grid distortion on the LF (<2 kHz) and HF (>2 kHz) emission of an AC/DC converter. The PFC boost converter is used as a particular case for validation of the results. It is observed that the AC/DC converters emit additional LF interharmonics and subharmonics when the grid voltage contains interharmonic components in the SH range. A mathematical analysis is provided to study and assess the interference between the SH in the background distortion and the AC/DC converters. Experimental studies are then performed for a PFC boost setup based on dSPACE MicroLabBox for the purposes of validating the mathematical analysis.
The Influence of the Geometry of Grooves on the Operating Parameters of the Impeller in a Centrifugal Pump with Microgrooves
Authors: Bieganowski Marcin , Skrzypacz Janusz , Chomiuk Bartłomiej
Published: June 2024

Centrifugal pumps are one of the most widely used machines in all branches of industry. For this reason, their efficiency has a significant impact on energy consumption in global industry (about 20%). It is extremely difficult to design low-specific-speed centrifugal pumps at acceptable efficiency levels due to increasing losses in the impeller (hydraulic, volumetric, and mechanical). This article presents the influence of the geometric features of grooves (width, depth), and the number of them, on the operating parameters of the impeller in a centrifugal pump with microgrooves. The principle of operation of this solution involves the passive control of the flow in the boundary layer using rectangular grooves. The grooves are made inside the flow channels of the impeller and are intended to reduce hydraulic losses occurring during flow. This is mainly due to a reduction in losses in the boundary layer. In order to determine the influence of the grooves’ parameters on the energy characteristics of the impeller, numerical calculations and experimental measurements were performed on 15 sets of impellers, which were obtained using experimental planning methods. The CFD calculations were conducted in order to understand the flow phenomena that occur in the impeller with the microgeometry and their effect on a reduction in internal flow losses. Based on the research results, useful guidelines for designing impellers with low-speed characteristics were formulated.
Optimization of Energy Consumption in a Wastewater Treatment Plant: An Overview
Authors: Tsalas Nikolaos , Golfinopoulos Spyridon K. , Samios Stylianos , Katsouras Georgios , Peroulis Konstantinos
Published: June 2024

Wastewater Treatment Plants (WWTPs) play a crucial role in maintaining ecological balance, a cornerstone of environmental health for thriving biodiversity and undisturbed natural processes. This balance is crucial for the sustainability of ecosystems, directly influencing human health, biodiversity, and the overall quality of our natural environment. WWTPs contribute to this equilibrium by efficiently removing pollutants and harmful substances from wastewater, thus averting the degradation of water bodies that are essential for numerous ecological processes. WWTPs encompass multiple stages of wastewater and sludge treatment and are significant energy consumers globally, especially in secondary treatment, particularly the activated sludge method which is the most common method. With an upcoming directive from the European Union aiming to reduce energy consumption in WWTPs, this paper focuses on a literature review examining global practices implemented across all stages of WWTP treatment processes. It summarizes the key points of each study, focusing primarily on the outcomes of each application. This document concludes with an in-depth review of each study and provides general conclusions for each group of studies. The objective is to identify methods that have effectively reduced energy consumption and enhanced the overall energy efficiency of WWTPs. The main conclusions indicate that the studies encompass a wide range of applications that achieve significant reductions in energy consumption. However, additional testing of these applications in more diverse operating environments through trials could further enhance their reliability and increase acceptance among WWTP operators.
The Influence of Addition of Expired Pharmaceuticals on Thermal Behaviour of Selected Types of Biomass
Authors: Strojwas Andrzej , Zubkova Valentina , Banas Dariusz , Stabrawa Ilona
Published: June 2024

The influence of 2 wt.% additives of expired paracetamol and naproxen on the thermal behaviour of densified samples of pea husks (PH), corncobs (CC), and sunflower inflorescences (SI) was studied using an analytical TG/FTIR unit. Gaseous, liquid, and solid pyrolysis products were evaluated using XRD, SEM, and EDX techniques along with FT-IR, ATR, and UV spectroscopies. It was found that the additives changed the yield and composition of pyrolysis products differently. The addition of paracetamol increases the contribution of guaiacyl rings in the condensed material of all samples, and the addition of naproxen—that of chromophores originating from the decomposition of lignin. The additives diversely affected the contribution of hydrocarbons in the composition of volatile products of pyrolysis: they decreased this contribution in PH samples, increased it in SI samples, and did not change in CC samples. The additives used changed the morphology and composition of organic and inorganic parts of pyrolyzed biomass. These changes in inorganics caused the changes in the composition of pyrolysis products. The conducted research proves not only the possibility of the utilization of expired pharmaceuticals during their pyrolysis with densified PH and CC samples but also the ability to reduce the undesirable hydrocarbons in the obtained volatile products.
Determination of Performance of Different Pad Materials and Energy Consumption Values of Direct Evaporative Cooler
Authors: Jakubowski Tomasz , Boyacı Sedat , Kocięcka Joanna , Atılgan Atılgan
Published: June 2024

The purpose of this study is to determine the performances of luffa and greenhouse shading netting (which can be used as alternatives to commercial cellulose pads, that are popular for cooling greenhouses), the contribution of external shading to the evaporative cooling performance, and the energy consumption of the direct evaporative cooler. In this experiment, eight different applications were evaluated: natural ventilation (NV), natural ventilation combined with external shading net (NV + ESN), cellulose pad (CP), cellulose pad combined with external shading net (CP + ESN), luffa pad (LP), luffa pad combined with external shading net (LP + ESN), shading net pad (SNP), and shading net pad combined with external shading net (SNP + ESN). The cooling efficiencies of CP, CP + ESN, LP, LP + ESN, SNP, and SNP + ESN were found to be 37.6%, 45.0%, 38.9%, 41.2%, 24.4%, 29.1%, respectively. Moreover, their cooling capacities were 2.6 kW, 3.0 kW, 2.8 kW, 3.0 kW, 1.7 kW, 2.0 kW, respectively. The system water consumption values were 2.9, 3.1, 2.8, 3.2, 2.4, 2.4 l h−1, respectively. The performance coefficients of the system were determined to be 10.2, 12.1, 11.3, 11.9, 6.6, 7.8. The system’s electricity consumption per unit area was 0.15 kWh m−2. As a result of the study, it was determined that commercially used cellulose pads have advantages over luffa and shading net materials. However, luffa pads can be a good alternative to cellulose pads, considering their local availability, initial cost, cooling efficiency, and capacity.
The Cost Reduction Potential of Demand Response in Balancing Markets from a System Perspective
Authors: Bakker Wessel , Lampropoulos Ioannis
Published: June 2024

Demand response (DR) can potentially provide a cost-efficient alternative for balancing the electricity grid by replacing fossil-fuelled power plants for the provision of flexible capacity. This paper aims to quantify the cost reduction potential of DR from a system perspective. Historical data of balancing markets are studied using regression and average bid price analysis to quantify the effect of the participation of DR resources on the price of flexible capacity for the provision of balancing reserves by focusing on two case studies in Great Britain and the Netherlands. It is estimated that DR bids are, on average, 35% lower than the market average. The regression analysis concluded that 1% higher participation of DR in balancing markets leads, on average, to a 2.7% lower prices for flexible capacity. The results verify the hypothesis that flexible DR capacity is offered at a lower price on balancing markets compared to conventional generation resources, resulting in lower costs for grid operators to balance the grid, thus reducing societal costs for electricity provision and overall emissions through the integration of low-carbon balancing resources.
Neuro-Fuzzy Framework for Fault Prediction in Electrical Machines via Vibration Analysis
Authors: Kudelina Karolina , Raja Hadi Ashraf
Published: June 2024

The advent of Industry 4.0 has ushered in a new era of technological advancements, particularly in integrating information technology with physical devices. This convergence has given rise to smart devices and the Internet of Things (IoT), revolutionizing industrial processes. However, despite the push towards predictive maintenance, there still is a significant gap in fault prediction algorithms for electrical machines. This paper proposes a signal spectrum-based machine learning approach for fault prediction, specifically focusing on bearing faults. This study compares the effectiveness of traditional neural network algorithms with a novel approach integrating fuzzy logic. Through extensive experimentation and analysis of vibration spectra from various mechanical faults in bearings, it is demonstrated that the fuzzy-neuro network model outperforms traditional neural networks, achieving a validation accuracy of 99.40% compared to 94.34%. Incorporating fuzzy logic within the neural network framework offers advantages in handling complex fault combinations, showing promise for applications requiring higher accuracy in fault detection. While initial results are encouraging, further validation with more complex fault scenarios and additional fuzzy layers is recommended to fully explore the potential of fuzzy-neuro networks in fault prediction for electrical machines.
Evaluating the Use of Grape Pomace in Cyprinus carpio Nutrition: Effects on Growth, Biochemistry, Meat Quality, Microbiota, and Oxidative Status
Authors: Barbacariu Cristian-Alin , Dîrvariu Lenuța , Șerban Dana Andreea , Rîmbu Cristina Mihaela , Horhogea Cristina Elena , Dumitru Gabriela , Todirașcu-Ciornea Elena , Lungoci Constantin , Burducea Marian
Published: June 2024

This study investigated the effects of incorporating grape pomace (GP) into fish diets on the growth performance, physiological parameters, and biochemical composition of carp (Cyprinus carpio L.). A total of 180 carp, with an average initial weight of 65 g, were reared in a recirculating aquaculture system (RAS). They were divided into a control group (C), fed with a diet containing 0% GP, and two experimental groups (V1 and V2), fed with diets containing 5% and 10% GP, respectively. The experiment lasted for eight weeks. Results revealed that most growth parameters were not significantly affected by GP inclusion, except for a notable difference in the hepatosomatic index (HSI), indicating an impact on liver size relative to body weight. The biochemical analysis of carp meat showed significant differences in moisture, protein, fat, collagen, and salt content between the control and experimental groups. Furthermore, the oxidative status assessment indicated that GP supplementation modulates oxidative stress and lipid peroxidation pathways in carp, enhancing their antioxidant defenses and overall health. Microbiological examination of the carp intestinal content showed that GP inclusion in fish diets influenced microbial parameters, particularly affecting the abundance of aerobic germs and Enterobacteriaceae.
Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model
Authors: Hernández-Martín Marina , Garcimartín Alba , Bocanegra Aránzazu , Redondo-Castillejo Rocío , Quevedo-Torremocha Claudia , Macho-González Adrián , García Fernández Rosa Ana , Bastida Sara , Benedí Juana , Sánchez-Muniz Francisco José , López-Oliva María Elvira
Published: June 2024

Silicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal and hepatic molecular mechanisms by which Si-RM exerts its cholesterol-lowering effects remain unclear. Male Wistar rats fed an RM included in a high-saturated-fat high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection were used as late-stage type 2 diabetes mellitus (T2DM) model. Si-RM was included into the HSFHCD as a functional food. An early-stage TD2M group fed a high-saturated-fat diet (HSFD) was taken as reference. Si-RM inhibited the hepatic and intestinal microsomal triglyceride transfer protein (MTP) reducing the apoB-containing lipoprotein assembly and cholesterol absorption. Upregulation of liver X receptor (LXRα/β) by Si-RM turned in a higher low-density lipoprotein receptor (LDLr) and ATP-binding cassette transporters (ABCG5/8, ABCA1) promoting jejunal cholesterol efflux and transintestinal cholesterol excretion (TICE), and facilitating partially reverse cholesterol transport (RCT). Si-RM decreased the jejunal absorptive area and improved mucosal barrier integrity. Consequently, plasma triglycerides and cholesterol levels decreased, as well as the formation of atherogenic lipoprotein particles. Si-RM mitigated the dyslipidemia associated with late-stage T2DM by Improving cholesterol homeostasis. Silicon could be used as an effective nutritional approach in diabetic dyslipidemia management.
Exploring the Phytochemical Composition and the Bioactive Properties of Malbec and Torrontés Wine Pomaces from the Calchaquíes Valleys (Argentina) for Their Sustainable Exploitation
Authors: Tapia Pablo Ezequiel , Silva Ana Margarida , Delerue-Matos Cristina , Moreira Manuela , Rodrigues Francisca , Torres Carro Romina , Santi María Daniela , Ortega María Gabriela , Blázquez María Amparo , Arena Mario Eduardo , Alberto María Rosa
Published: June 2024

Hydroalcoholic extracts from Malbec and Torrontés wine pomaces (Vitis vinifera L.) originating from the high-altitude vineyards of Argentina’s Calchaquí Valleys were characterized. Total phenolics, hydroxycinnamic acids, orthodiphenols, anthocyanins, non-flavonoid phenolics, total flavonoids, flavones/flavonols, flavanones/dihydroflavonols, and tannins were quantified through spectrophotometric methods, with the Malbec extract exhibiting higher concentrations in most of phytochemical groups when compared to Torrontés. HPLC-DAD identified more than 30 phenolic compounds in both extracts. Malbec displayed superior antiradical activity (ABTS cation, nitric oxide, and superoxide anion radicals), reduction power (iron, copper, and phosphomolybdenum), hypochlorite scavenging, and iron chelating ability compared to Torrontés. The cytotoxicity assessments revealed that Torrontés affected the viability of HT29-MTX and Caco-2 colon cancer cells by 70% and 50%, respectively, at the highest tested concentration (1 mg/mL). At the same time, both extracts did not demonstrate acute toxicity in Artemia salina or in red blood cell assays at 500 µg/mL. Both extracts inhibited the lipoxygenase enzyme (IC50: 154.7 and 784.7 µg/mL for Malbec and Torrontés), with Malbec also reducing the tyrosinase activity (IC50: 89.9 µg/mL), and neither inhibited the xanthine oxidase. The substantial phenolic content and diverse biological activities in the Calchaquí Valleys’ pomaces underline their potentialities to be valorized for pharmaceutical, cosmetic, and food industries.
Older Adults’ Exposure to Food Media Induced Unhealthy Eating during the COVID-19 Omicron Lockdown? Exploring Negative Emotions and Associated Literacy and Efficacy on Shanghainese
Authors: Jiao Wen
Published: June 2024

The COVID-19 pandemic, propelled by the highly transmissible Omicron variant, had a global impact and significantly affected Shanghai, a major city in China. This study investigates how food media exposure influenced unhealthy eating habits among older adults during the COVID-19 lockdown in Shanghai, focusing on the roles of negative emotions, food literacy, health consciousness, and eating self-efficacy. The random sample comprised 400 individuals aged ≥50 years who lived in Shanghai from March to June 2022. A path and correlation analysis was performed. The exposure of older adults to food media resulted in the acceleration of unhealthy eating. The relationship was significantly exacerbated by food literacy and negative emotions. In contrast, eating self-efficacy and health consciousness effectively countered the media. The enhanced pathway from food-related media influence to eating habits through negative emotions or self-efficacy towards health awareness and food literacy showed significant effects. The findings provide insights for future research and public health strategies. Importantly, this study has practical significance for media professionals, public health decision-makers, and healthy food businesses regarding how to enhance older adults’ cognition to respond to unhealthy eating crises.
Commercial Production of Highly Rehydrated Soy Protein Powder by the Treatment of Soy Lecithin Modification Combined with Alcalase Hydrolysis
Authors: Ren Shuanghe , Du Yahui , Zhang Jiayu , Zhao Kuangyu , Guo Zengwang , Wang Zhongjiang
Published: June 2024

The low rehydration properties of commercial soy protein powder (SPI), a major plant−based food ingredient, have limited the development of plant−based foods. The present study proposes a treatment of soy lecithin modification combined with Alcalase hydrolysis to improve the rehydration of soy protein powder, as well as other processing properties (emulsification, viscosity). The results show that the soy protein–soy lecithin complex powder, which is hydrolyzed for 30 min (SPH–SL−30), has the smallest particle size, the smallest zeta potential, the highest surface hydrophobicity, and a uniform microstructure. In addition, the value of the ratio of the α−helical structure/β−folded structure was the smallest in the SPH–SL−30. After measuring the rehydration properties, emulsification properties, and viscosity, it was found that the SPH–SL−30 has the shortest wetting time of 3.04 min, the shortest dispersion time of 12.29 s, the highest solubility of 93.17%, the highest emulsifying activity of 32.42 m2/g, the highest emulsifying stability of 98.33 min, and the lowest viscosity of 0.98 pa.s. This indicates that the treatment of soy lecithin modification combined with Alcalase hydrolysis destroys the structure of soy protein, changes its physicochemical properties, and improves its functional properties. In this study, soy protein was modified by the treatment of soy lecithin modification combined with Alcalase hydrolysis to improve the processing characteristics of soy protein powders and to provide a theoretical basis for its high−value utilization in the plant−based food field.
Further Hermite–Hadamard-Type Inequalities for Fractional Integrals with Exponential Kernels
Authors: Li Hong , Meftah Badreddine , Saleh Wedad , Xu Hongyan , Kiliçman Adem , Lakhdari Abdelghani
Published: June 2024

This paper introduces new versions of Hermite–Hadamard, midpoint- and trapezoid-type inequalities involving fractional integral operators with exponential kernels. We explore these inequalities for differentiable convex functions and demonstrate their connections with classical integrals. This paper validates the derived inequalities through a numerical example with graphical representations and provides some practical applications, highlighting their relevance to special means. This study presents novel results, offering new insights into classical integrals as the fractional order β approaches 1, in addition to the fractional integrals we examined.
Analysis of Passenger Car Tailpipe Emissions in Different World Regions through 2050
Authors: Senzeybek Murat , Feinauer Mario , Dasgupta Isheeka , Ehrenberger Simone
Published: June 2024

This study presents a carbon dioxide (CO2), exhaust particulate matter (PM2.5) and nitrogen oxide (NOx) tailpipe emission analysis of passenger cars in nine countries, representing different world regions up to 2050 using a bottom-up calculation method. A diffusion model is used to analyze the development of different drivetrain/fuel technologies in the respective vehicle stocks of each world region. Drivetrain- and country-specific emission factors are weighted according to the modelled stock compositions. The obtained stock fleets’ average emission factors are multiplied by the transport demand in order to obtain the total passenger car emissions. Our findings reveal global passenger car CO2, NOx and PM2.5 emissions decrease by approximately 45%, 63% and 54%, respectively, between 2015 and 2050. Gasoline will remain a significant energy carrier in 2050 with about a 25% stock share. However, electric vehicles will be in the lead, especially after 2040. Additionally, rising transport demand offsets emission reductions in some regions. This study aims to provide global and regional insights into future emissions trends and their driving factors.
The Innate Immune System Surveillance Biomarker p87 in African Americans and Caucasians with Small High-Grade Dysplastic Adenoma [SHiGDA] and Right-Sided JAK3 Colon Mutations May Explain the Presence of Multiple Cancers Revealing an Important Minority of Patients with JAK3 Mutations and Colorectal Neoplasia
Authors: Tobi Martin , Zhao Xiaoqing , Rodriquez Rebecca , Tobi Yosef Y. , Ganguly Tapan , Kuhn Donald , McVicker Benita , Lawson Michael J. , Lieb John , Lopes Jaime L.
Published: June 2024

Colorectal cancer (CRC) outcomes in terms of incidence and mortality are significantly worse in African Americans than other Americans. While differences in primary preventions for neoplasia (diet, obesity remediation, aspirin prophylaxis) are being elucidated, genetic mutations affecting premalignant lesions and immune response mechanisms may possibly also explain the increased incidence and mortality, particularly from right-sided disease. Objective: Our team therefore examined colonic segments seeking to test the hypothesis that the immune response and somatic genetic profiles of the colonic anatomic segments may vary and thus account for variations in neoplasia risk among the various colonic segments revealing an antigenic relationship with precancerous lesions. The p87 antigenic field effect is recognized via Adnab-9 antibody immunohistochemistry to be significantly less in the right colon in African Americans, particularly in the cecum. Method: Since small high-grade dysplastic adenomas (SHiGDA) likely missed by CRC screening may progress to cancer, we used Ion Torrent™ sequencing of DNA extracted from four normal colonic segments (two left-sided and two right) of patients with SHiGDAs. We also contrasted unique mutational fields in one patient with a large HiGDA (APC with unique mutations) and one patient who prospectively developed a SHiGDA (JAK3). Result: The SHiGDA (small high-grade dysplastic polyp) patient was p87 negative for any extracted stool, saliva, or colonic effluent via ELISA (enzyme linked immunoadsorbant assay). Furthermore, mean values of expression in segments from the right colon were reduced with respect to the means obtained from the left segments in 233 patients evaluated for a p87 field effect. This has recently been shown to be the case in a large cohort of AA and Caucasian 2294 patients, possibly explaining the right-sided CRC disparity in African Americans and the subsequent increase in mortality. This field effect disparity is also true for two cancers contracted by the SHiGDa patient (lung and prostate). Conclusion: Thus, this pilot study suggests that the reduction in p87 in the right colon is possibly correlated with JAK3 mutations. If confirmed, JAK3 mutations, known to be associated with immune aberrations, may provide a mechanistic explanation for the lack of a p87 (protein 87 kilodaltons) field in some patients with HGD polyps who might benefit from possible intervention such as more intensive screening. Limited microbiome studies were also performed on two patients with familial cancer syndromes and these compared favorably with controls available from the literature.
Exploring the Genomic Landscape: A Comprehensive Analysis of the Genetic Diversity and Population Structure of Thai Tomato Germplasm through Whole-Genome Sequencing (WGS)
Authors: Yongsuwan Arweewut , Poncheewin Wasin , Sastawittaya Wittaya , Somkul Akarachai , Thunnom Burin , Aesomnuk Wanchana , Bhunchoth Anjana , Phironrit Namthip , Phuangrat Bencharong , Koohapitakthum Ratree , Deeto Rungnapa , Warin Nuchnard , Wanchana Samart , Arikit Siwaret , Chatchawankanphanich Orawan , Chuenwarin Paweena , Ruanjaichon Vinitchan
Published: June 2024

Tomatoes (Solanum lycopersicum L.) represent a valuable crop species cultivated on a global scale, with Thailand playing a notable role in Southeast Asia’s agricultural landscape. However, a comprehensive understanding of the genetic underpinnings, population dynamics, and genetic correlations among tomato cultivars within Thailand remains relatively nascent. This study conducted an extensive analysis of 283 tomato accessions sourced from Thailand’s largest germplasm repository, employing approximately 2.4 million single-nucleotide polymorphisms (SNPs) obtained through whole-genome sequencing (WGS). The results of the genetic diversity assessment demonstrate a consistent delineation of groups, as indicated by UPGMA clustering, revealing five distinct clusters, while population structure analysis unveils twelve subpopulations. These findings underscore the limited genetic reservoir within Thai tomato germplasm, providing valuable insights for germplasm management strategies and offering a promising avenue for the refinement of breeding programs aimed at enhancing tomato genetics.