bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI FUZZY TAHANI DALAM PENENTUAN PEMBELIAN SMARTPHONE
Authors: Wahyu Dwi Prasetio  , Astuti Zahrroh  , Abdul Khudri Barkah Rizki  , Achmad Rilwanul Izzati  , Danny Brantadikara  , Widhia Oktoeberza KZ
Published: June 2023

Sebanyak 65.87% penduduk Indonesia telah memiliki telepon seluler pada tahun 2021. Pasar smartphone di Indonesia diperkirakan meningkat 8% dari tahun sebelumnya menjadi 44 juta unit pada tahun 2022. Pengguna harus mempertimbangkan berbagai faktor seperti harga, spesifikasi, dan lain-lain sebelum memutuskan untuk membeli smartphone. Dalam upaya pengembangan sistem pendukung pemilihan smartphone, penelitian menggunakan metode Fuzzy Tahani. Fuzzy inference system model Tahani akan memproses input yang diberikan oleh user kemudian mengembalikan hasil proses berupa output list rekomendasi smartphone kepada user yang diurut berdasarkan nilai fire strength. Sebagai hasil akhir, model logika fuzzy Tahani dapat digunakan untuk memberikan rekomendasi pemilihan smartphone yang akurat dengan mempertimbangkan berbagai kriteria secara proporsional.
Multistability in a Circulant Dynamical System
Authors: RECH Paulo
Published: June 2023

In this paper we report on a two parameter four-dimensional dynamical system with cyclic symmetry, namely a circulant dynamical system. This system is a twelve-term polynomial system with four cubic nonlinearities. Reported are some parameter-space diagrams for this system, all of them considering the same range of parameters, but generated from different initial conditions. We show that such diagrams display the occurrence of multistability in this system. Properly generated bifurcation diagrams confirm this finding. Basins of attraction of coexisting attractors in the related phase-space are presented, as well as an example showing phase portraits for periodic and chaotic coexisting attractors.
Insights para o estabelecimento de valores de referência de ácido úrico na população pediátrica
Authors: Ferranti Mayara Fernanda , Souza Anna Carolina Huppes de , Vasconcelos Ana Luiza de Paula , Oliveira Marcia Rosangela Neves de , Bonfim-Mendonça Patrícia de Souza
Published: June 2023

Introdução: A nefrolitíase é uma doença que acomete o sistema renal, caracterizada pelo acúmulo de analitos e formação de cálculos renais. Estudos atuais têm demonstrado particularidades da excreção de analitos urinários em populações de acordo com sua faixa etária. Além disso, o analito ácido úrico exerce papel muito importante na formação de cálculos renais. Assim, nossa pesquisa propôs avaliar concentrações de ácido úrico em amostras de urina 24 horas de crianças e adolescentes com o intuito de trazer à insights sobre a determinação de valores de referência mais coerentes. Metodologia: Neste estudo analítico transversal foram coletadas 25 amostras de urina (24h) de crianças e adolescentes, sem comorbidades, para o estabelecimento de valores de referência na faixa etária entre 4 a 11 anos, e de 12 a 18 anos, respectivamente. Resultados: Os resultados obtidos não apontam diferença estatística significativa nos parâmetros sexo e volume da população total. No entanto, quando observados isoladamente que os adolescentes apresentaram uma maior concentração de ácido úrico. Nossa proposta direciona o uso de intervalos percentis de 109 e 321,8 mg/24h para a população pediátrica. Conclusão: Esse estudo propôs insights sobre valores de referência para as populações com as faixas etárias citadas anteriormente, entretanto ressaltamos a necessidade de mais pesquisas referentes a essa temática e possível adequação deste estudo aos requisitos estipulados por protocolos padrão como Clinical and Laboratory Standards.
Análise da importância da nutrição no desempenho do atleta profissional de futebol
Authors: Silva Darlyson dos Santos , Silva Maria Cláudia da
Published: June 2023

O futebol é o esporte mais popular do mundo, prática que exige muito dos atletas fisicamente devido seu alto nível de intensidade, quantidade de jogos durante a temporada, quantidade de treinos e pouco tempo para descanso, sendo necessário uma estratégia específica para alinhar a nutrição e o condicionamento físico. Desta forma, o objetivo deste trabalho foi analisar a importância da nutrição no desempenho do atleta profissional de futebol. A metodologia utilizada foi uma revisão literária descritiva com artigos publicados de 2012 a 2023, pesquisa de artigos foi feita nas bases de dados da PUBMED (público/editora), Google Acadêmico (Google Scholar) e Scielo (Scientific Electronic Library Online). Assim, observou-se que o consumo dos nutrientes como carboidratos (CHO), proteínas (PTN) e lipídeos (LIP) alinhados com hidratação e, se necessário, suplementação, são fundamentais para resultados positivos dos jogadores e consequentemente para o clube em geral. O que demonstrou a importância e necessidade da presença do profissional da nutrição para alcançar bons resultados do clube e alta performance dos jogadores. Conclui-se que a partir dos dados apresentados, verificou-se que os clubes de futebol precisam introduzir nos projetos para a temporada da equipe um profissional de Nutrição, atuando no desempenho dos jogadores e na prevenção de lesões.
Uso de Glutationa e Vitamina C na criopreservação seminal de touros Nelore
Authors: Parizi Fernando de Castro , Julio Vanessa Balan , Kulik Karine , Vaz Eduarda Stankiwich , Paes Francielle Amorim da Silva , Laskoski Luciane Maria , Ferrari Marcos Vinicius , Souza Fernando Andrade
Published: June 2023

Uma forma de aumentar a eficiência reprodutiva e o mérito genético de um rebanho é através do uso de biotecnologias como a inseminação artificial e a fertilização in vitro, nas quais o sêmen congelado é essencial. Assim, objetivou-se com este estudo comparar as concentrações de glutationa e vitamina-C como agentes antioxidantes, sendo alocados seis ejaculados de seis touros diferentes para cada grupo. Cada ejaculado foi exposto a quatro tratamentos (controle/ 1,25mM/ 2,5mM/ 5,0mM) tanto para glutationa, quanto para vitamina C. Após a criopreservação realizaram-se testes para avaliar a qualidade seminal pós descongelamento por meio dos testes hiposmótico, de longevidade espermática e do giemsa/azul de Tripan. Não se contrastou grupo de touros, apenas tratamentos dentro de cada grupo. Para o grupo glutationa não houve diferença significativa (P>0,05) entre os resultados e as concentrações utilizadas, já no grupo vitamina-C a concentração de 5,0 mM apresentou resultados desfavoráveis em comparação as demais, indicando lesão de membrana acrossomal, sendo contraindicada.
A promoção da saúde da mulher na senescência – Terapêutica nutricional
Authors: Carvalho Veronica Christine Lages Freitas de , Lacerda Vilma de Oliveira Chaves , Maynard Dayanne da Costa
Published: June 2023

A menopausa é um processo fisiológico natural na vida da mulher caracterizado pelo fim da função ovariana. Apesar de não ser uma patologia, nessa fase ocorre o declínio dos hormônios estrogênio e progesterona. O presente estudo teve como objetivo verificar, durante a senescência, como a alimentação pode influenciar na redução de sinais e sintomas da menopausa, com foco na qualidade de vida. O estudo foi feito com base na revisão de dados da literatura científica nacional e internacional, utilizando as bases de dados Scielo, Pubmed e Google acadêmico, com pesquisas em artigos científicos e documentos institucionais. A terapia de reposição hormonal (TRH) ajudou amenizar os sintomas da menopausa relacionados ao declínio do estrogênio como a secura vaginal, os fogachos, a insônia e a ansiedade, mas apenas durante o uso, porque essa fase está diretamente associada ao estresse oxidativo progressivo das funções fisiológicas potencializando a perda da densidade mineral óssea (DMO) induzindo a perda da massa magra e aumentando a massa gorda. As intervenções nutricionais mais efetivas foram a dieta DASH, que ajudou reduzir a hipertensão, e a Mediterrânea (MedD), que ajudou reduzir os eventos cardiovasculares, combinada com dietas hiperproteicas associadas com atividade física regular. As opções de tratamento para os sintomas do climatério incluíram a terapia de reposição hormonal (TRH) de estrogênio e progesterona combinada por via oral ou transdérmica isolado ou combinado, e também opções naturais, como o uso de isoflavonas (soja) e a folha de amora, entre outros.
História da implantação da eletroconvulsoterapia no Hospital Geral Público de Palmas
Authors: Ferroli Beatriz , Baldaçara Leonardo
Published: June 2023

A eletroconvulsoterapia (ECT), como método terapêutico eficaz, seguro, internacionalmente reconhecido e aceito, deve ser realizada em condições apropriadas. Neste artigo será apresentado um relato descritivo e histórico sobre a implantação do procedimento ECT no Estado do Tocantins, incluindo suas dificuldades e êxitos. Para tal, foi realizada uma pesquisa qualitativa e descritiva. Foram observadas resistências nas equipes de saúde e em gestores por estigma e desconhecimento. Entretanto, a orientação e os bons resultados permitiram vencer barreiras e fazer o procedimento ser aceito e demandado. Para o futuro espera-se ampliar as atividades de neuromodulação, seja por mais indicações e maior número de aplicações técnicas.
Avaliação da suplementação de beta-alanina no desempenho esportivo
Authors: Santos Eduardo Figueirêdo dos , Oliveira Luana Bernardes de , Pereira-Castro Maína Ribeiro
Published: June 2023

A suplementação de beta-alanina tem sido amplamente utilizada como um suplemento alimentar para melhorar o desempenho físico. Seus efeitos positivos estão associados ao aumento da carnosina muscular, que proporciona maior resistência e redução da fadiga durante os treinos em diferentes modalidades esportivas. Posto isso, este artigo tem como objetivo apresentar uma revisão bibliográfica narrativa que explora os benefícios da suplementação de beta-alanina no desempenho esportivo e sua influência na composição corporal. A revisão também enfoca o papel da beta-alanina na formação da carnosina, um composto dipeptídeo presente naturalmente no corpo humano. Os resultados destacam que a beta-alanina apresenta benefícios no desempenho físico, com apenas um efeito colateral facilmente evitado, contribuindo para a melhoria da resistência e redução da fadiga muscular durante os treinos de resistência. Os estudos investigados demonstram que a suplementação de beta-alanina contribui para o melhor desenvolvimento do exercício, elevando os níveis de carnosina e minimizando a sensação de fadiga, resultando em aprimoramento do rendimento físico.
Total training volume for the treatment of shoulder impingement syndrome: a systematic review protocol with meta-analysis
Authors: Aristides Paulo Rodrigo Santos , Góes Ana Lúcia Barbosa , Sá Kátia Nunes
Published: June 2023

This systematic review protocol with meta-analysis aims to verify the effects of the total volume of resistance training on pain outcomes and functional capacity in individuals with Shoulder Impingement Syndrome. This review will be developed following the steps of formulation of the research question, search for randomized clinical trials, selection of studies considering the eligibility criteria, data extraction, analysis and synthesis of evidence. The question will be based on PICOS strategy: “What total volumes of resistance training reduce pain and improve function in individuals with shoulder impingement syndrome?” Searches will be carried out in 12 databases and gray literature sources. The results will be exported to the Rayyan application so that two independent and blind reviewers can perform the exclusion of duplicates and selection of studies by reading titles and abstracts. Randomized clinical trials that analyzed the effects of resistance training in the treatment of shoulder impingement syndrome will be selected for full-text reading, of which, studies that meet the eligibility criteria will have their data extracted and submitted to narrative synthesis and, if possible, to the meta-analysis. The Physiotherapy Evidence Database (PEDro) tools will be used to analyze the methodological quality and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) for the quality of the evidence.
Application of UV-C irradiation prevented a severe outbreak of proliferative kidney disease in rainbow trout aquaculture
Authors: Naas C , Kappe A , Schmidt-Posthaus H , Lichtenecker M
Published: June 2023

There is an urgent need to establish protocols on how to protect salmonids in aquaculture from outbreaks of proliferative kidney disease (PKD). For this purpose, systems for a continuous application of peracetic acid (PAA, 0.1 mg l-1) and of ultraviolet C light (UV-C, 323.5-158.6 mW s cm-2) were installed in the inlet of raceway-channels within a sub-unit of a commercial rainbow trout Oncorhynchus mykiss farm. After 127 d of rearing, a fish health examination was conducted. Fish in the control and PAA treatment groups showed signs of PKD. In contrast, fish in the UV-C treatment group showed almost no signs of disease based on clinical examinations and necropsy. This observation indicates that UV-C irradiation could be a promising tool to protect fish from PKD in the future.
Association Between Problematic Internet Use and Health Risks in Adolescents With and Without Chronic Health Conditions
Authors: Klavina Aija , Veliks Viktors , Bebrisa-Fedotova Luize , Zusa Anna , Porozovs Juris , Aniscenko Aleksandrs
Published: June 2023

Background. Sedentary and unhealthy lifestyle behaviors are modifiable health risks that often develop during adolescence. A comprehensive analysis of unhealthy behaviors in adolescents with and without chronic health conditions (CHC) could inform the development of more effective prevention approaches.

The aim. This study aimed to measure associations between Problematic Internet Use (PIU), lifestyle habits and subjective health complaints among adolescents with and without CHC. In addition, health behaviors and prevalence of subjective health complaints between adolescents with and without CHC were compared.

Methods. A total of 171 adolescents (87 without CHC and 84 with CHC) completed an online survey. The PIU was assessed by the Problematic and Risky Internet Use Screening Scale. The subjective health complaints assessed were somatic and psychological symptoms. Healthy lifestyle behaviors assessed were daily physical activities, time spent by screens, eating habits, and duration of sleep.

Results. The results showed that 21.83% of adolescents with CHC and 36.78% without CHC scored at risk for problematic internet use. Adolescents without CHC reported significantly more frequent psychological health complaints than their peers with CHC. This study found that multiple health complaints and unhealthy eating habits were significantly associated with PIU in adolescents with CHC, while nervousness and eating fast food in adolescents without CHC. Girls without CHC reported significantly higher PRIUSS scores and prevalence of subjective health complaints than boys (p <.05).

Conclusions. Adolescents without CHC reported significantly higher levels of moderate and vigorous intensity physical activities weekly than their peers with CHC. PIU behaviors are mainly associated with psychological health complaints and unhealthy eating behaviors in adolescents with and without CHC. These findings highlight the need to identify the specific problematic internet use activities that are associated with different health risks in adolescents.

Keywords: problematic internet use, chronic health conditions, lifestyle behaviors, health, adolescents.
Relationship Between Functional Movements of the Mandible and Core Stability in Young Healthy Adults
Authors: Skinderytė Vaida , Zachovajevienė Brigita , Žlibinaitė Laura
Published: June 2023

Background. Temporomandibular joints (TMJs) have a common neuromuscular connection with neck and scapula, so dysfunction of one or both joints can lead to changes in the spine posture and vice versa. Due to the compensatory mechanism, occurring following TMJ functional disorders, the balance between facial and neck muscle activity is disrupted. A change in any biomechanical unit inevitably results in a change of the posture control system, but there is a lack of research evaluating the relationship between functional movements of the TMJ and trunk stability.

The aim. To determine the relationship between core stability and functional movements of the mandible.

Methods. The study included 20 participants aged between 20 and 40 years. Participants were tested individually. Tests and measurements selected for the study: trunk stability assessment by functional Dynamic Neuromuscular Stabilization (DNS) tests; assessment of static trunk muscle endurance by McGill endurance tests; assessment of TMJ range of motion using a ruler.

Results. Participants performed best on the DNS Supine test with legs raised up, and performed worst on the squat, bear position tests and trunk extension static endurance test. 90% of the participants had impaired range of motion of mandible protrusion, 60% had mandibular depression limitations. The static endurance of trunk flexion was 136.85±96.97 s, extension – 141.45±94.52 s, left side– 98.00±76.08 s, right side– 99.95±96, 99 s.

Conclusion. There are strong, moderate and weak linear inverse functional relationships between trunk stability and TMJ mobility. The weaker the core stability, the more restricted the mobility of the mandible.

Keywords: temporomandibular joint, TMJ dysfunction, dynamic neuromuscular stabilization, core stability.
Comparative Analysis of Motor Skills Between 10–12-Year-Old Boys Volleyball Players and Physically Inactive Peers
Authors: Kiaulakytė Rosita , Katinė Anelė
Published: June 2023

Background. The gross motor function of team sports athletes is superior to that of peers who do not participate in additional physical activity, but it is not clear to what extent motor skills diﬀer between boys who attend volleyball training and those who do not attend training.
The aim. To compare the motor skills and functional stability of the trunk of 10–12-year-old volleyball-playing and physically inactive boys.
Methods. 30 subjects, boys aged 10–12, participated in the study. The research group consisted of boys playing volleyball (n=15), the control group – physically inactive boys (n=15). Test tools: Bruininks Oseretsky Motor Skills Profciency Test, 2nd Edition and Matthiass Functional Trunk Stability Test.
Results. Boy volleyball players showed signifcantly better results in only three of ten evaluated motor tasks compared to inactive boys: side jumps with legs together (8.07±1.03 points vs. 7.27±0.88, p=0.026) and push-ups (5.93±1.28 points vs. 4.53±0.99, p=0.002), and V-up (4.73±1.28 points vs. 3.20±1.27, p=0.009). The result of functional stability test was better in volleyball players than in non-players (24.67±9.26 points vs. 16.53±9.34, p=0.013).
Conclusions. Boys who play volleyball had signifcantly better motor skills in strength and agility tasks compared with boys who are physically inactive. No signifcant diﬀerences were found in bilateral coordination, balance and upper extremity coordination tasks between volleyball players and physically inactive boys, but the functional stability of the trunk of boys who play volleyball was signifcantly better than that of physically inactive boys.
Keywords: motor skills, functional trunk stability, volleyball, physically inactive
The TANTANGAN KETERWAKILAN PEREMPUAN DALAM POLITIK FORMAL
Authors: Fauziah Marsyifa Novia , Rizki Mochamad Faizal , Ramdani Rachmat
Published: June 2023

Penelitian tentang tantangan keterwakilan perempuan dalam politik formal membahas tentang proses perjuangan perempuan Indonesia dalam politik hingga saat ini. Selain itu, tulisan ini juga membedah faktor-faktor yang dianggap menjadi alasan mengapa perempuan dapat menduduki pucuk pimpinan baik di ranah eksekutif maupun legislatif atau sebagai bupati/walikota/gubernur beserta wakilnya. Faktor-faktor tersebut adalah biaya politik, pendukung partai dan hubungan keluarga. Penelitian ini disusun dengan menggunakan metode penelitian kualitatif deskriptif dengan teknik pengumpulan data menggunakan tinjauan pustaka. Dan hasil penelitian ini mengatakan bahwa biaya politik di Indonesia tergantung pada wilayah, jumlah penduduk dan ketersediaan sumber daya alam di setiap daerah. Partai pengusung sebagai media pemungutan suara dan hubungan kekeluargaan sebagai cara berkomunikasi dan membentuk personal branding secara cepat.
Changes in blood pressure, blood sugar and creatinine in patients undergoing pheochromocytoma surgery
Authors: SEVACH Prashant , SHARMA Govind , PRİYADARSHİ Shivam
Published: June 2023

Objective: To discover the variables that may predict changes in blood pressure and blood sugar levels and to pinpoint the time frame during which such changes occur in patient with pheochromocytoma. Materials and Methodology: Consecutive patients undergoing surgery for pheochromocytoma over a 20-month period were included in this ethics review board-approved, prospective cohort study. Blood pressure and sugar levels were serially monitored using a fixed protocol in the perioperative period and subsequently at 3 months after surgery. Changes were compared and assessed for the predictive factors. Result: Fifty patients undergoing surgical procedures were included in the study of whom 32% developed hypotension and 10% developed hypoglycaemias after surgery. All hypotension episodes occurred within 6 hours of surgery. However, while 7 of 8 patients who developed hypoglycaemia manifest in the first 4 h after surgery, one occurred after 12 h. Occurrence of hypotension correlated with preoperative 24-h urinary vanillylmandelic acid levels (P = 0.024). Out of 21 hypertensive patients, 15 had persistent hypertension at 3 months and this was associated with age (P = 0.04) and diabetes mellitus at presentation. Conclusion: 32% of patients receiving pheochromocytoma surgery experienced postoperative hypotension needing inotropic support. Patients who require greater dosages of alpha-blockers or those with higher 24-h urine VMA levels are more prone to experience this. This happens within the first six hours following surgery. Patients who are older or who have had DM for a long time are more likely to suffer chronic HTN following surgery. Keywords: Pheochromocytoma, hypertension, hypoglycaemia, creatinine.
The Role of Universitas Terbuka-Indonesia in Improving Higher Education Services in Indonesia
Authors: Armida Sari Jayanti , Darmanto Darmanto , Wahyudi Heri , Yulianti Isnaeni
Published: June 2023

This study examines UT Indonesia's experience and learning in an effort to expand the quantity and improve the quality of higher education in Indonesia. The aim is to comprehensively analyze the role of UT Indonesia in providing higher education services, increasing the outreach of higher education, and quality assurance. This study uses literature studies to assess, critique, and synthesize literature on research topics that allow for the emergence of new theoretical frameworks and perspectives. The review process includes four phases: design, implementation, analysis, and finally writing a review. Studies show that UT Indonesia has a very important role in optimizing the field of higher education for the community. UT's excellence as a distance university is largely determined by the quality of service in the form of student satisfaction. In addition, with the characteristics of the distance education system, UT can be considered as a solution to various educational problems, especially those related to equity and democratization of education, as well as expanding access to quality education for all levels of society across time and space. Lastly, high-tech learning models and quality assurance systems can be implemented based on ICT. It is important to use a quality circle approach in developing DE courses and learning materials for students. UT has an important role in improving the accessibility and quality of ICT-based education in Indonesia because of its cost effectiveness and flexibility in the implementation of learning.
Computer-aided screening of aspiration risks in dysphagia with wearable technology: a Systematic Review and meta-analysis on test accuracy
Authors: Lai Derek Ka-Hei , Cheng Ethan Shiu-Wang , Lim Hyo-Jung , So Bryan Pak-Hei , Lam Wing-Kai , Cheung Daphne Sze Ki , Wong Duo Wai-Chi , Cheung James Chung-Wai
Published: June 2023

Aspiration caused by dysphagia is a prevalent problem that causes serious health consequences and even death. Traditional diagnostic instruments could induce pain, discomfort, nausea, and radiation exposure. The emergence of wearable technology with computer-aided screening might facilitate continuous or frequent assessments to prompt early and effective management. The objectives of this review are to summarize these systems to identify aspiration risks in dysphagic individuals and inquire about their accuracy. Two authors independently searched electronic databases, including CINAHL, Embase, IEEE Xplore® Digital Library, PubMed, Scopus, and Web of Science (PROSPERO reference number: CRD42023408960). The risk of bias and applicability were assessed using QUADAS-2. Nine (n = 9) articles applied accelerometers and/or acoustic devices to identify aspiration risks in patients with neurodegenerative problems (e.g., dementia, Alzheimer’s disease), neurogenic problems (e.g., stroke, brain injury), in addition to some children with congenital abnormalities, using videofluoroscopic swallowing study (VFSS) or fiberoptic endoscopic evaluation of swallowing (FEES) as the reference standard. All studies employed a traditional machine learning approach with a feature extraction process. Support vector machine (SVM) was the most famous machine learning model used. A meta-analysis was conducted to evaluate the classification accuracy and identify risky swallows. Nevertheless, we decided not to conclude the meta-analysis findings (pooled diagnostic odds ratio: 21.5, 95% CI, 2.7–173.6) because studies had unique methodological characteristics and major differences in the set of parameters/thresholds, in addition to the substantial heterogeneity and variations, with sensitivity levels ranging from 21.7% to 90.0% between studies. Small sample sizes could be a critical problem in existing studies (median = 34.5, range 18–449), especially for machine learning models. Only two out of the nine studies had an optimized model with sensitivity over 90%. There is a need to enlarge the sample size for better generalizability and optimize signal processing, segmentation, feature extraction, classifiers, and their combinations to improve the assessment performance.

Systematic Review Registration: (https://www.crd.york.ac.uk/prospero/), identifier (CRD42023408960).
The combination of multi-approach studies to explore the potential therapeutic mechanisms of imidazole derivatives as an MCF-7 inhibitor in therapeutic strategies
Authors: Rashid Maryam , Maqbool Ayesha , Shafiq Nusrat , Bin Jardan Yousef A. , Parveen Shagufta , Bourhia Mohammed , Nafidi Hiba-Allah , Khan Rashid Ahmed
Published: June 2023

Breast cancer covers a large area of research because of its prevalence and high frequency all over the world. This study is based on drug discovery against breast cancer from a series of imidazole derivatives. A 3D-QSAR and activity atlas model was developed by exploring the dataset computationally, using the machine learning process of Flare. The dataset of compounds was divided into active and inactive compounds according to their biological and structural similarity with the reference drug. The obtained PLS regression model provided an acceptable r2 = 0.81 and q2 = 0.51. Protein-ligand interactions of active molecules were shown by molecular docking against six potential targets, namely, TTK, HER2, GR, NUDT5, MTHFS, and NQO2. Then, toxicity risk parameters were evaluated for hit compounds. Finally, after all these screening processes, compound C10 was recognized as the best-hit compound. This study identified a new inhibitor C10 against cancer and provided evidence-based knowledge to discover more analogs.
Association of sex and cardiovascular risk factors with atherosclerosis distribution pattern in lower extremity peripheral artery disease
Authors: Baretella Oliver , Buser Laura , Andres Claudine , Häberli Dario , Lenz Armando , Döring Yvonne , Baumgartner Iris , Schindewolf Marc
Published: June 2023

Objective

Atherosclerosis expression varies across not only coronary, cerebrovascular, and peripheral arteries but also within the peripheral vascular tree. The underlying pathomechanisms of distinct atherosclerosis phenotypes in lower extremity peripheral artery disease (PAD) is poorly understood. We investigated the association of cardiovascular risk factors (CVRFs) and atherosclerosis distribution in a targeted approach analyzing symptomatic patients with isolated anatomic phenotypes of PAD.

Methods

In a cross-sectional analysis of consecutive patients undergoing first-time endovascular recanalization for symptomatic PAD, data of patients with isolated anatomic phenotypes of either proximal (iliac) or distal (infrageniculate) atherosclerosis segregation were extracted. We performed a multivariable logistic regression model with backward elimination to investigate the association of proximal and distal PAD with CVRFs.

Results

Of the 637 patients (29% females) with endovascular recanalization, 351 (55%) had proximal and 286 (45%) had distal atherosclerosis. Female sex [odds ratio (OR) 0.33, 95% confidence interval (CI) 0.20–0.54, p = 0.01], active smoking (OR 0.16, 95% CI 0.09–0.28, p < 0.001), and former smoking (OR 0.33, 95% CI 0.20–0.57, p < 0.001) were associated with proximal disease. Diabetes mellitus (DM) (OR 3.25, 95% CI 1.93–5.46, p < 0.001), chronic kidney disease (CKD) (OR 1.18, 95% CI 1.08–1.28, p < 0.001), and older age (OR 1.31, 95% CI 1.06–1.61, p = 0.01) were associated with distal disease.

Conclusion

Female sex, particularly in the context of smoking, is associated with clinically relevant, proximal atherosclerosis expression. Our additional findings that distal atherosclerosis expression is associated with DM, CKD, and older age suggest that PAD has at least two distinct atherosclerotic phenotypes with sex-specific and individual susceptibility to atherogenic risk factors.
Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people
Authors: Allalou Amal , Peng Junjie , Robinson George A. , Marruganti Crystal , D’Aiuto Francesco , Butler Gary , Jury Elizabeth C. , Ciurtin Coziana
Published: June 2023

Worrying trends of increased cardiovascular disease (CVD) risk in children, adolescents and young people in the Modern Era have channelled research and public health strategies to tackle this growing epidemic. However, there are still controversies related to the dynamic of the impact of sex, age and puberty on this risk and on cardiovascular health outcomes later in life. In this comprehensive review of current literature, we examine the relationship between puberty, sex determinants and various traditional CVD-risk factors, as well as subclinical atherosclerosis in young people in general population. In addition, we evaluate the role of chronic inflammation, sex hormone therapy and health-risk behaviours on augmenting traditional CVD-risk factors and health outcomes, ultimately aiming to determine whether tailored management strategies for this age group are justified.
Bilateral lung transplantation for pediatric pulmonary arterial hypertension: perioperative management and one-year follow-up
Authors: Jack Thomas , Carlens Julia , Diekmann Franziska , Hasan Hosan , Chouvarine Philippe , Schwerk Nicolaus , Müller Carsten , Wieland Ivonne , Tudorache Igor , Warnecke Gregor , Avsar Murat , Horke Alexander , Ius Fabio , Bobylev Dmitry , Hansmann Georg
Published: June 2023

Background

Bilateral lung transplantation (LuTx) remains the only established treatment for children with end-stage pulmonary arterial hypertension (PAH). Although PAH is the second most common indication for LuTx, little is known about optimal perioperative management and midterm clinical outcomes.

Methods

Prospective observational study on consecutive children with PAH who underwent LuTx with scheduled postoperative VA-ECMO support at Hannover Medical School from December 2013 to June 2020.

Results

Twelve patients with PAH underwent LuTx (mean age 11.9 years; age range 1.9–17.8). Underlying diagnoses included idiopathic (n = 4) or heritable PAH (n = 4), PAH associated with congenital heart disease (n = 2), pulmonary veno-occlusive disease (n = 1), and pulmonary capillary hemangiomatosis (n = 1). The mean waiting time was 58.5 days (range 1–220d). Three patients were bridged to LuTx on VA-ECMO. Intraoperative VA-ECMO/cardiopulmonary bypass was applied and VA-ECMO was continued postoperatively in all patients (mean ECMO-duration 185 h; range 73–363 h; early extubation). The median postoperative ventilation time was 28 h (range 17–145 h). Echocardiographic conventional and strain analysis showed that 12 months after LuTx, all patients had normal biventricular systolic function. All PAH patients are alive 2 years after LuTx (median follow-up 53 months, range 26–104 months).

Conclusion

LuTx in children with end-stage PAH resulted in excellent midterm outcomes (100% survival 2 years post-LuTx). Postoperative VA-ECMO facilitates early extubation with rapid gain of allograft function and sustained biventricular reverse-remodeling and systolic function after RV pressure unloading and LV volume loading.
Effect of hypertriglyceridemia on left ventricular global longitudinal strain in patients with coronary heart disease in Jilin Province, China: a cross-sectional study
Authors: Na Lin , Cui Wenjing , Li Xinqi , Chang Jing , Xue Xin
Published: June 2023

Aims

Using speckle tracking technology to investigate the effect of hypertriglyceridemia on the global longitudinal strain(GLS) of the left ventricle in patients with coronary heart disease in the early stage, and to explore the value of myocardial strain in early identification of cardiac dysfunction in patients with coronary heart disease in the pre-heart failure stage.

Methods

A cross-sectional study of 138 participants was conducted in Jilin Province, China. Basic clinical, biochemical, and echocardiographic data were obtained for all patients. Myocardial strain parameters were compared between the hypertriglyceridemia and normal triglyceride level groups and the effect of hypertriglyceridemia on early left ventricular global longitudinal strain impairment in coronary heart disease patients was evaluated.

Results

The overall longitudinal strain of the left ventricle was smaller in the hypertriglyceridemia group than in the normal triglyceride group. After the multivariate Logistic regression model adjusting for the influence of confounding factors, the results remained stable.

Conclusions

The risk of impairment of global longitudinal strain of the left ventricle in patients with coronary heart disease is positively correlated with triglyceride levels, and hypertriglyceridemia maybe an independent risk factor affecting early cardiac dysfunction in the pre-heart failure stage of patients with coronary heart disease.
Assessing the impacts of reservoirs on downstream hydrological frequency based on a general rainfall-reservoir index
Authors: Li Rongrong , Xu Guoce
Published: June 2023

When large reservoirs are built and put into operation, the downstream hydrological processes will be altered significantly, and ecology and agricultural irrigation water of the basin will be affected to some extent. The reservoir index (RI) and the sediment trapping efficiency (TE) of reservoirs are defined to quantify the reservoir impacts on the water flow and sediment by considering the static storage capacity. However, the regulating effect of reservoirs on hydrological variables is not only related to static storage capacity, but also to dynamic reservoir operation. Thus, in this paper, a general rainfall-reservoir index (GRRI) is developed by coupling reservoir regulation indicator (RR, including RI and TE) and effective rainfall affecting the dynamic operation of reservoirs, and the GRRI is used as the covariate to carry out the nonstationary frequency analysis of flood (Q) and annual sediment load (S) at Gaochang (GC) station in Min River, Wulong (WL) station in Wu River, Ankang (AK), Huangjiagang (HJG) and Huangzhuang (HZ) station in Han River, and Cuntan (CT) station on the main stream of the upper Yangtze River. It is found that Q and S at six stations have obvious changes induced by reservoirs, the mean of Q decreases by 22.8%–60.6%, and S drops by 47.7%–89.5% after the change-point of time series. The nonstationary probability distribution models with GRRI as the covariate have better fitting effects than nonstationary models with RR as the covariate. With the incorporation of the impacts of effective rainfall, the GRRI can more accurately capture the occurrence of nonstationarity in the downstream hydrological frequency. These results might be helpful for exploring the impact mechanism of the reservoir regulation on the downstream hydrological variables as well as ecological management of basin.
Traditional ecological knowledge and its role in biodiversity conservation: a systematic review
Authors: Sinthumule Ndidzulafhi I.
Published: June 2023

In various parts of Africa, scholars have paid a great deal of attention to TEK, focusing mainly on their role in biodiversity conservation or natural resource management. Despite individual efforts made so far, the consolidated information about the role of TEK in biodiversity conservation remains uncertain in Africa. A systematic literature search on the role of TEK in biodiversity conservation was conducted on ISI Web of Science (WoS), Scopus and Google Scholar databases. The search produced 40 papers in 12 countries in Africa that were published between 2001 and 2022. Majority of studies on TEK (40%; n = 16) reported in the reviewed literature were from West Africa and no study was found in North Africa. The study found the regular use of different but interrelated forms of TEK in Africa. These include taboos and totems, customs and rituals, rules and regulations, metaphors and proverbs, traditional protected areas (social institutions), local knowledge of plants, animals and landscapes, and resource management systems. Although these forms of TEK have great potential for in situ natural resource management, metaphors and proverbs were found to be least addressed (n = 4) component of TEK. Despite TEK having played a significant role in biodiversity conservation in present-day Africa, the traditions are being threatened by changing cultural mores and practices (including Christianity and Islam), formal education, modernisation and new political dispensations. The findings of this study demonstrate that large geographic areas remain unexplored and this may hide part of the narrative. Reviewed literature suggests that metaphors and proverbs are least represented. New studies should be dedicated towards filling these gaps. Based on these findings, recommendations are provided to improve management practices for TEK in Africa.
Parental gonadossomatic mosaicism in HIVEP2-related intellectual disability and impact on genetic counseling–case report
Authors: Abreu Maria , Branco Tiago , Figueiroa Sónia , Reis Cláudia Falcão
Published: June 2023

Intellectual development disorder, autosomal dominant 43 (MRD43) is an autosomal dominant disorder caused by heterozygous mutations in the HIVEP2 gene. In this report, we describe a case of a 4-year-old boy with global development delay, hypotonia, and dysmorphic features, in whom the finding of a heterozygous nonsense pathogenic variant in exon 5 of HIVEP2 [c.2827C>T p. (Arg943*)] through WES established a MRD43 diagnosis. Our patient’s phenotype overlaps with other MRD43 descriptions in the literature. Unlike previously reported cases, where the condition was almost invariably de novo, the healthy mother in this case presented mosaicism for the pathogenic variant. Thus, the recurrence risk increased significantly from 1% to up to 50%. The description of a variant inherited for MDR43 is singular in the literature and this description highlights the importance of parental studies for accurate genetic counseling, particularly for family planning.
Defibrotide modulates pulmonary endothelial cell activation and protects against lung inflammation in pre-clinical models of LPS-induced lung injury and idiopathic pneumonia syndrome
Authors: Klein Orly R. , Ktena Yiouli P. , Pierce Elizabeth , Fu Han-Hsuan , Haile Azeb , Liu Chen , Cooke Kenneth R.
Published: June 2023

Introduction

A multiple organ dysfunction syndrome (MODS) workshop convened by the National Institute of Child Health and Human Development in 2015 identified acute respiratory distress syndrome (ARDS) and complications of allogeneic blood and marrow transplantation (allo-BMT) as contributors to MODS in pediatric patients. Pulmonary dysfunction also remains a significant complication of allo-BMT. Idiopathic pneumonia syndrome (IPS) defines non-infectious, acute, lung injury that occurs post-transplant. Injury and activation to endothelial cells (ECs) contribute to each form of lung inflammation.

Methods

Two murine models were employed. In an ARDS model, naïve B6 mice receive an intravenous (i.v.) injection of lipopolysaccharide (LPS). In the established model of IPS, naïve B6D2F1 mice receive lethal total body irradiation followed by BMT from either allogeneic (B6) or syngeneic (B6D2F1) donors. Lung inflammation was subsequently assessed in each scenario.

Results

Intravenous injection of LPS to B6 mice resulted in enhanced mRNA expression of TNFα, IL-6, Ang-2, E-, and P-selectin in whole lung homogenates. The expression of Ang-2 in this context is regulated in part by TNFα. Additionally, EC activation was associated with increased total protein and cellularity in broncho-alveolar lavage fluid (BALF). Similar findings were noted during the development of experimental IPS. We hypothesized that interventions maintaining EC integrity would reduce the severity of ARDS and IPS. Defibrotide (DF) is FDA approved for the treatment of BMT patients with sinusoidal obstruction syndrome and renal or pulmonary dysfunction. DF stabilizes activated ECs and protect them from further injury. Intravenous administration of DF before and after LPS injection significantly reduced mRNA expression of TNFα, IL6, Ang-2, E-, and P-selectin compared to controls. BALF showed decreased cellularity, reflecting less EC damage and leak. Allogeneic BMT mice were treated from day -1 through day 14 with DF intraperitoneally, and lungs were harvested at 3 weeks. Compared to controls, DF treatment reduced mRNA expression of TNFα, IL6, Ang-2, E-, and P- selectin, BALF cellularity, and lung histopathology.

Conclusion

The administration of DF modulates EC injury in models of ARDS and IPS. Cytokine inhibition in combination with agents that stabilize EC integrity may be an attractive strategy for patients in each setting.
Long-term shoreline changes at large spatial scales at the Baltic Sea: remote-sensing based assessment and potential drivers
Authors: Tiede Jan , Jordan Christian , Moghimi Armin , Schlurmann Torsten
Published: June 2023

In this study, we demonstrate how freely available satellite images can be used to understand large-scale coastline developments along the coast of Mecklenburg-Western Pomerania (MWP). By validating the resulting dataset with an independent Light Detection and Ranging (LIDAR) dataset, we achieved a high level of accuracy for the calculation of rates of change (ROC) with a root mean square error (RMSE) of up to 0.91 m, highlighting the reliability of Earth observation data for this purpose. The study assessed the coastal system’s natural evolution from 1984 to 1990, prior to significant human interventions, and examined the period from 1996 to 2022, which was characterized by regular sand nourishments amounting to approximately 16 million m³. The results reveal notable changes in the study area, with a significant decline in erosive trends and an increase in the number of stable and accreting transects. However, it is important to note that the regular sand nourishments may be masking the true ROC along the coastline. Furthermore, the future supply of sand raises concerns about the sustainability of coastal developments, particularly in the context of future sea level rise (SLR). The study provides valuable insights for coastal authorities and policymakers, informing decisions on sand resource allocation and highlighting the need for appropriate adaptation strategies to address future SLR and ensure long-term coastal resilience.
Current and potential roles of immuno-PET/-SPECT in CAR T-cell therapy
Authors: Mulgaonkar Aditi , Udayakumar Durga , Yang Yaxing , Harris Shelby , Öz Orhan K. , Ramakrishnan Geethakumari Praveen , Sun Xiankai
Published: June 2023

Chimeric antigen receptor (CAR) T-cell therapies have evolved as breakthrough treatment options for the management of hematological malignancies and are also being developed as therapeutics for solid tumors. However, despite the impressive patient responses from CD19-directed CAR T-cell therapies, ~ 40%−60% of these patients' cancers eventually relapse, with variable prognosis. Such relapses may occur due to a combination of molecular resistance mechanisms, including antigen loss or mutations, T-cell exhaustion, and progression of the immunosuppressive tumor microenvironment. This class of therapeutics is also associated with certain unique toxicities, such as cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and other “on-target, off-tumor” toxicities, as well as anaphylactic effects. Furthermore, manufacturing limitations and challenges associated with solid tumor infiltration have delayed extensive applications. The molecular imaging modalities of immunological positron emission tomography and single-photon emission computed tomography (immuno-PET/-SPECT) offer a target-specific and highly sensitive, quantitative, non-invasive platform for longitudinal detection of dynamic variations in target antigen expression in the body. Leveraging these imaging strategies as guidance tools for use with CAR T-cell therapies may enable the timely identification of resistance mechanisms and/or toxic events when they occur, permitting effective therapeutic interventions. In addition, the utilization of these approaches in tracking the CAR T-cell pharmacokinetics during product development and optimization may help to assess their efficacy and accordingly to predict treatment outcomes. In this review, we focus on current challenges and potential opportunities in the application of immuno-PET/-SPECT imaging strategies to address the challenges encountered with CAR T-cell therapies.