bluuebunny/crossref_metadata_2025 huggingface dataset:
Retórica do Arquivamento
Authors: Gregate Lucas Henrique
Published: April 2020

Ao fim do século XIX e começo do século XX, Campinas, localizada no oeste paulista, passava por profundas mudanças: um dos principais centros do comércio cafeeiro oitocentista viu um incipiente esforço modernizador se instaurar conforme a industrialização se concretizava no município. Com isso, a cidade passou por uma substancial mudança de seu centro enquanto novas construções aos moldes da linguagem arquitetônica eclética se popularizavam. Tais transformações marcam tanto a organização espacial, quanto a história de Campinas. Nesse contexto, o Conselho de Defesa do Patrimônio Cultural de Campinas (CONDEPACC), o departamento de história da Unicamp e a FAPESP deram início, em 2005, à produção do Inventário do Centro Histórico Expandido de Campinas, com o objetivo de catalogar esses imóveis e servir-lhes como ferramenta de preservação. No entanto, a maioria dos estudos de tombamento abertos através do Inventário foram desfigurados e arquivados. A presente pesquisa, através de estudo documental desses processos renegados, visitas de campo aos imóveis e do debate historiográfico em relação ao arquivo, ao patrimônio, à memória e ao esquecimento, passou a tratar o inventário também como ferramenta historiográfica. Como resultado, construiu-se o termo não-patrimônio como sugestão de categoria dos estudos patrimoniais para caracterizar os processos de estudo de tombamento arquivados, mas plenamente funcionais enquanto fontes narrativas da História.
Reflexões sobre a presença do Movimento Negro Contemporâneo (1960-1990) em Livros Didáticos (2008, 2011 e 2014)
Authors: Ferreira Vitor Emanuel Maia
Published: April 2020

Partindo das contribuições teóricas de Chartier (1991), Hall (2016) e Ricouer (2007) acerca do conceito “representação”, o presente trabalho utilizou como objeto 18 volumes de livros didáticos (e cada um destes de uma coleção distinta) aprovados e reeditados pelo Programa Nacional do Livro Didático (PNLD) nos anos de 2008, 2011 e 2014 e destinados ao último ano do Ensino Fundamental. Procurou-se identificar nestes os tratos dispensados à experiência afro-brasileira no pós-abolição, especificamente no recorte das atividades do Movimento Negro Contemporâneo aqui por nós entendido como entre 1970 e 2000. Tal adoção temporal se justifica por permitir que outras variantes de resistência sejam identificadas para além do modo institucionalizado que tem seu início marcado tradicionalmente em 1978 com o surgimento do Movimento Negro Unificado (MNU). Ademais, estende-se o recorte de análise dos livros didáticos até 1960. Tal ação se justifica por permitir que nos atentemos para as atividades estadunidenses semelhantes que se intensificam sobretudo nas décadas de 50 e 60 e, assim, apontar de que maneira a narrativa didática a aborda. Concluído tal movimento, torna-se possível sustentar algumas propostas, como: preferências sobre o que é entendido como “movimento social”, o que se desdobra na continuidade de “valores” que eram forçosamente propostos pelo Regime Militar (1964-1985) vigente no período. Assim, pretende-se apontar para a afirmação de que o Movimento Negro Contemporâneo brasileiro carece de maior espaço nas coleções didáticas para que se atribua a luta do Movimento Negro maior sentido de longevidade e continuidade.
Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection
Authors: Saleh Moussa , Gabriels James , Chang David , Soo Kim Beom , Mansoor Amtul , Mahmood Eitezaz , Makker Parth , Ismail Haisam , Goldner Bruce , Willner Jonathan , Beldner Stuart , Mitra Raman , John Roy , Chinitz Jason , Skipitaris Nicholas , Mountantonakis Stavros , Epstein Laurence M.
Published: April 2020

Background:

The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is responsible for the global coronavirus disease 2019 pandemic. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine±azithromycin for the treatment of coronavirus disease 2019. Use of these medications alone, or in combination, can lead to a prolongation of the QT interval, possibly increasing the risk of Torsade de pointes and sudden cardiac death.

Methods:

Hospitalized patients treated with chloroquine/hydroxychloroquine±azithromycin from March 1 to the 23 at 3 hospitals within the Northwell Health system were included in this prospective, observational study. Serial assessments of the QT interval were performed. The primary outcome was QT prolongation resulting in Torsade de pointes. Secondary outcomes included QT prolongation, the need to prematurely discontinue any of the medications due to QT prolongation, and arrhythmogenic death.

Results:

Two hundred one patients were treated for coronavirus disease 2019 with chloroquine/hydroxychloroquine. Ten patients (5.0%) received chloroquine, 191 (95.0%) received hydroxychloroquine, and 119 (59.2%) also received azithromycin. The primary outcome of torsade de pointes was not observed in the entire population. Baseline corrected QT interval intervals did not differ between patients treated with chloroquine/hydroxychloroquine (monotherapy group) versus those treated with combination group (chloroquine/hydroxychloroquine and azithromycin; 440.6±24.9 versus 439.9±24.7 ms,
P
=0.834). The maximum corrected QT interval during treatment was significantly longer in the combination group versus the monotherapy group (470.4±45.0 ms versus 453.3±37.0 ms,
P
=0.004). Seven patients (3.5%) required discontinuation of these medications due to corrected QT interval prolongation. No arrhythmogenic deaths were reported.

Conclusions:

In the largest reported cohort of coronavirus disease 2019 patients to date treated with chloroquine/hydroxychloroquine±azithromycin, no instances of Torsade de pointes, or arrhythmogenic death were reported. Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. Further study of the need for QT interval monitoring is needed before final recommendations can be made.
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction
Authors: Dai Wenli , Nadadur Rangarajan D. , Brennan Jaclyn A. , Smith Heather L. , Shen Kaitlyn M. , Gadek Margaret , Laforest Brigitte , Wang Mingyi , Gemel Joanna , Li Ye , Zhang Jing , Ziman Bruce D. , Yan Jiajie , Ai Xun , Beyer Eric C. , Lakata Edward G. , Kasthuri Narayanan , Efimov Igor R. , Broman Michael T. , Moskowitz Ivan P. , Shen Le , Weber Christopher R.
Published: April 2020

Rationale:

ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 (
TJP1
) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap, and adherens junction proteins and localizes to intercalated discs in cardiomyocytes. However, the contribution of ZO-1 to cardiac physiology remains poorly defined.

Objective:

We aim to determine the role of ZO-1 in cardiac function.

Methods and Results:

Inducible cardiomyocyte-specific
Tjp1
deletion mice (
Tjp1

fl/fl

;
Myh6

Cre/Esr1*

) were generated by crossing the
Tjp1
floxed mice and
Myh6

Cre/Esr1*

transgenic mice. Tamoxifen-induced loss of ZO-1 led to atrioventricular (AV) block without changes in heart rate, as measured by ECG and ex vivo optical mapping. Mice with tamoxifen-induced conduction system-specific deletion of
Tjp1
(
Tjp1

fl/fl

; Hcn4

CreERt2

) developed AV block while tamoxifen-induced conduction system deletion of
Tjp1
distal to the AV node (
Tjp1

fl/fl

; Kcne1

CreERt2

) did not demonstrate conduction defects. Western blot and immunostaining analyses of AV nodes showed that ZO-1 loss decreased Cx (connexin) 40 expression and intercalated disc localization. Consistent with the mouse model study, immunohistochemical staining showed that ZO-1 is abundantly expressed in the human AV node and colocalizes with Cx40. Ventricular conduction was not altered despite decreased localization of ZO-1 and Cx43 at the ventricular intercalated disc and modestly decreased left ventricular ejection fraction, suggesting ZO-1 is differentially required for AV node and ventricular conduction.

Conclusions:

ZO-1 is a key protein responsible for maintaining appropriate AV node conduction through maintaining gap junction protein localization.
Behavioural and physiological responses to simulated predator-induced stress in the eastern box turtle, Terrapene carolina carolina
Authors: Preston Victoria L. , Vannatta Jessica M. , Klukowski Matthew
Published: April 2020

In spite of the fully-hinged shell being the defining characteristic of box turtles, few studies have quantified the behavioural use of the shell in response to predator encounters. While it is often assumed that box turtles simply withdraw into their shell in response to threats, we expected variability among individuals in shell usage and in the degree of head and limb retraction because withdrawal is likely to be costly. We tested the behavioural and physiological responses of free-ranging eastern box turtles to stimuli of varying intensity: observation only, a visual stimulus, a poke on the leg, or a pinch on the leg before being flipped. The more intense the simulated predatory stimulus, the more likely turtles were to fully close their shell. However, stimulus intensity did not affect plasma corticosterone or lactate levels. This may be due to too brief or weak of a stimulus, increased parasympathetic activity, or seasonal effects. Upon capture and during handling, almost all turtles withdrew into their shells and closed their anterior plastron, although fewer closed their posterior plastron, and a few engaged in other behaviours such as biting and urinating. Older, larger turtles were able to close their shells with greater strength than younger and smaller turtles. Our results indicate that in spite of their fully closable shell, box turtles exhibit a graded response to perceived threats. This suggests that full closure of the shell is likely to be costly and occurs only in response to the most intense stimuli.
Limitations to Freedom of Religion or Belief in Denmark
Authors: Lassen Eva Maria
Published: April 2020

The article analyses legislative changes in the area of freedom of religion or belief in Denmark between 2014 and 2018. Recent legislation has placed pressure particularly on religious minorities to limit certain religious manifestations, and it is possible to trace a certain “juridification” of freedom of religion, by which the values underlying freedom of religion according to international standards are not always fully reflected. Additionally, there is a tendency to address societal concerns by means of legal interventions. The article argues that by making increased use of soft law developed by the EU, the Council of Europe and the UN, Danish lawmakers would be able to reach a more comprehensive understanding of freedom of religion or belief as well as include non-legal solutions to societal concerns. It further argues that while Denmark’s national (Lutheran) church possess the majority of constituents, nonetheless its privileged position may paradoxically strengthen freedom of religion for religious minorities.
Pilostyles maya, a novel species from Mexico and the first cleistogamous species in Apodanthaceae (Cucurbitales)

Authors: ORTEGA-GONZÁLEZ PACTLI F. , RIOS-CARRASCO SANDRA , GONZÁLEZ-MARTÍNEZ CÉSAR ADRIÁN , BONILLA-CRUZ NATALIA , VÁZQUEZ-SANTANA SONIA
Published: April 2020

Pilostyles maya (Apodanthaceae), a new Mexican species endemic to the Yucatán Peninsula, is described and illustrated. Ecological, geographical, molecular, and morphological evidence are provided to support the new species status of Pilostyles maya. A molecular phylogenetic analysis based on the mitochondrial matR and nuclear 18S genes recovered P. maya as sister to P. mexicana. It is distinguished from its congeners by having cleistogamous, hermaphroditic flowers, tepals with ciliate margins and specificity on a Bauhinia host. These traits are novel for the genus and family. We propose that P. maya be listed as Critically Endangered due to its small known area of distribution and threats from deforestation in its area of occurrence.
Updated distribution and conservation assessment of Darcyanthus spruceanus, Deprea cardenasiana and Deprea ecuatoriana (Solanaceae): new reports for Peru and Brazil

Authors: CUEVA MANCHEGO MARCO A. , GRICH AGUSTINA , DEANNA ROCÍO
Published: April 2020

Darcyanthus and Deprea are neotropical nightshade genera with Andean distributions in South America. Here we present an updated distribution and conservation assessment of Darcyanthus spruceanus, Deprea cardenasiana and D. ecuatoriana, including the first report of D. cardenasiana in southern Peru and the monotypic Darcyanthus in western Brazil. In addition, D. ecuatoriana distribution in northern Peru is confirmed after new revision of herbarium material. Deprea cardenasiana occurs in the southern limit of the genus distribution and it had not been recollected after its discovery almost 79 years ago. Deprea ecuatoriana is currently restricted to the montane forests from northern Peru and southern Ecuador. The monotypic Darcyanthus reaches lowland areas, including Amazonian forest in Peru, Bolivia and Brazil. According to IUCN criteria, both D. cardenasiana and D. ecuatoriana are categorized as Endangered whereas Darcyanthus spruceanus is considered as a Least Concern species.
A new species of planthopper in the genus Haplaxius (Hemiptera: Auchenorrhyncha: Fulgoroidea: Cixiidae) on palms in Costa Rica and a new country record for Haplaxius skarphion
Authors: BAHDER BRIAN W. , BARRANTES EDWIN A. BARRANTES , ECHAVARRIA MARCO. A. ZUMBADO , MOU DE-FEN , HELMICK ERICKA E. , BARTLETT CHARLES R.
Published: April 2020

The genus Haplaxius is a large taxon of cixiid planthoppers that is of economic importance due to the ability of Haplaxius crudus to transmit lethal yellowing in coconut palms. Haplaxius dougwalshi sp. n. is established as a new taxon of Cixiidae in the tribe Oecleini collected from native palms in lowland tropical rainforest in Costa Rica. Placement in the genus Haplaxius is supported both by molecular evidence based on the COI and 18S genes as well as by morphological characters. This novel taxon was discovered during survey work in Costa Rica to look for phytoplasmas and document planthopper diversity on palms. Furthermore, Haplaxius skarphion was also collected from coconut palms during survey work and is reported for the first time in Costa Rica.
A Numerical Study on the Influences of Sumatra Topography and Synoptic Features on Tropical Cyclone Formation over the Indian Ocean
Authors: Wang Chung-Chieh , Ma Shin-Kai , Johnson Richard H.
Published: April 2020

Spanning across the equator with a northwest–southeast orientation, the island of Sumatra can exert significant influences on low-level flow. Under northeasterly flow, in particular, lee vortices can form and some of them may subsequently develop into tropical cyclones (TCs) in the Indian Ocean (IO). Building upon the recent work of Fine et al., this study investigates the roles of the Sumatra topography and other common features on the formation of selected cases for analysis and numerical experiments. Four cases in northern IO were selected for analysis and two of them [Nisha (2008) and Ward 2009)] for simulation at a grid size of 4 km. Sensitivity tests without the Sumatra topography were also performed. Our results indicate that during the lee stage, most pre-TC vortices tend to be stronger with a clearer circulation when the topography is present. However, the island’s terrain is a helpful but not a deciding factor in TC formation. Specifically, the vortices in the no-terrain tests also reach TC status, but just at a later time. Some common ingredients contributing to a favorable environment for TC genesis are identified. They include northeasterly winds near northern Sumatra, westerly wind bursts along the equator, and migratory disturbances (TC remnants or Borneo vortices) to provide additional vorticity/moisture from the South China Sea. These factors also appear in most of the 22 vortices in northern IO during October–December in 2008 and 2009. For the sole case (Cleo) examined in southern IO, the deflection of equatorial westerlies into northwesterlies by Sumatra (on the windward side) is also helpful to TC formation.
New Insight into Titanium–Magnesium Ziegler–Natta Catalysts Using Photoluminescence Spectroscopy
Authors: Panchenko Valentina N. , Kostyukov Anton I. , Shabalin Anton Yu , Paukshtis Evgeniy A. , Glazneva Tatiana S. , Kazarian Sergei G.
Published: April 2020

This paper presents the results of study of titanium–magnesium catalysts often used in polymerization processes, by photoluminescence spectroscopy (PL) in combination with diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). The interaction of dibutyl phthalate (DBP) with MgCl2 was studied at DBPadded/Mg = 0–1 (mol/mol). The luminescence spectra with excitation at 278 nm and the excitation spectra for main emission bands were recorded. It was shown that DBP adsorbed on magnesium chloride, both in the form of donor–acceptor complexes (D+A–) and in the form of molecular complexes. At DBPadded/Mg <0.15, the formation of D+A– complexes occur predominantly; with an increase in DBPadded/Mg, the fraction of molecular complexes increases. Molecular complexes are destroyed during the treatment of the support by TiCl4. In this case, the structure of magnesium chloride is disordered and new coordination–unsaturated sites are formed. This work is a first attempt to apply PL spectroscopy in combination with DRIFTS spectroscopy to study titanium–magnesium Ziegler–Natta catalysts. The application of PL spectroscopy to such systems made it possible to detect interactions within and between donor molecules, which would be particularly challenging to achieve using other spectroscopic methods. Both spectroscopic methods provided crucial information about the existence of two types of complexes on the sample surface which is important for tuning the synthesis procedure of the titanium–magnesium catalysts for olefin polymerization.
Transformational Leader or Narcissist? How Grandiose Narcissists Can Create and Destroy Organizations and Institutions
Authors: O’Reilly Charles A. , Chatman Jennifer A.
Published: April 2020

Transformational leaders challenge the status quo, provide a vision of a promising future, and motivate and inspire their followers to join in the pursuit of a better world. But many of these leaders also fit the American Psychiatric Association classification for narcissistic personality disorder. They are grandiose, entitled, self-confident, risk seeking, manipulative, and hostile. This article reviews the literature on narcissism and shows how what we think of as transformational leadership overlaps substantially with grandiose narcissism. As grandiose narcissists can appear as transformational leaders, it is important to distinguish between what leadership scholars have characterized as “transformational” and these “pseudo-transformational” candidates.
Establishment and Stability of the Murine Oral Microbiome
Authors: Abusleme L. , O’Gorman H. , Dutzan N. , Greenwell-Wild T. , Moutsopoulos N.M.
Published: April 2020

Commensal microbiomes exert critical functions at barrier sites. In particular, establishment of the commensal microbiome after birth dictates immune functionality and tissue homeostasis at mucosal surfaces. To investigate the establishment and stability of the oral mucosal microbiome in mice, we evaluated oral microbiome communities shortly after birth, through adulthood, and up to 1 y of life in a controlled manner, using sequential oral samples from the same mice over time. We further evaluated transmissibility of oral microbiomes from parents and during cohousing experiments and evaluated susceptibility to oral inflammatory disease in mice harboring distinct microbiomes. Our work reveals basic principles in the establishment and stability of a health-associated oral microbiome after birth and provides insights that may be important for host-microbiome experimentation in animal models.
A Gendered Career Stage Model to Explore Turnover Intent Among Correctional Officers
Authors: Griffin Marie L. , Lambert Eric G. , Hogan Nancy L. , Todak Natalie , Hepburn John
Published: April 2020

Understanding the factors that lead to correctional officer (CO) turnover intent is vital. Using a gendered career stage model, this study focused on male and female CO similarities and differences in workplace variable effects on turnover intent across career stages. The results indicated that organizational commitment was a consistent predictor of turnover intent for all correctional officers at all career stages, and, at various career stages, quality of supervision, coworker support, and safety concerns affected both males and females. Male officers were more likely to leave at all career stages, with the impact of job stress and role ambiguity influencing male turnover intent.
‘System of collective representations’ in humanist marriage ceremonies in Poland
Authors: Rejowska Agata
Published: April 2020

In Poland we observe that humanist (strongly individualized and mostly secular) marriages are growing in number. This article focuses mainly on the analysis of one of the elements of performance in humanist wedding ceremonies indicated by Jeffrey Alexander, which is ‘system of collective representations’. The analysis is divided into two parts. The first describes the theoretical framework, beginning with an outline of the Polish context with the main focus on the role of religion. Then it addresses the category of social performance by Alexander, and the broader theoretical contexts in which humanist marriage ceremonies can be inscribed (individualisation, transformations of contemporary love, changes in religiosity). In the second part this theoretical framework is applied to the gathered empirical material. The article concludes with the statement that the creation of new ceremonies leads to some transpositions into a wider system of meanings and attempts to describe these changes.
Characterization and analysis of the tensile and acoustic emission parameter distributions of single wool fibers
Authors: Lu Di , Yu Weidong
Published: April 2020

Acoustic emission (AE) parameters of damaged material have discrete characteristics that are universally known. Such characteristics restrict wider use of AE analysis in materials such as textiles. In the present work, the best-fitted distribution models of AE signal energy are analyzed: amplitude, duration, tensile breaking strength, elongation, and specific work of wool fibers. The parameters of Weibull, normal, and log-normal distribution models are obtained by regression analysis. The chi-square, Kolmogorov–Smirnov, and maximum likelihood criterions are used to discriminate against the above models. The results show that the Weibull distribution is the best-fitted model for amplitude and elongation of wool. The best-fitted model for energy, strength, and specific work is the log-normal distribution. The differences between the cumulative distributions of the AE and tensile parameters are compared. It can be seen that strength also has a high correlation coefficient and a similarly cumulative distribution with energy and amplitude. Compared to amplitude, the relationship between energy and strength is supposed to be stronger.
Structural characteristics and sound absorption properties of poplar seed fibers
Authors: Liu Yingjie , Lyu Lihua , Xiong Xiaoqing , Qian Yongfang , Li Hong , Guo Jing
Published: April 2020

In order to make reasonable utilization of poplar seed fibers, their macromolecular structure, supramolecular structure and morphological structure were analyzed by means of a biological microscope, scanning electron microscope, Fourier transform infrared spectrometer and X-ray diffractometer, and the relationship between the structure of poplar seed fiber and its sound absorption performance was explored. The acoustic impedance transfer function method was used to test the sound absorption performance of poplar seed fiber, kapok fiber, cotton fiber, wool fiber and hemp fiber aggregates that could be used in the field of sound absorption. The results showed that the order of sound absorption properties of the five fiber aggregates was as follows: kapok fiber, poplar seed fiber, cotton fiber, wool fiber, hemp fiber. The special structure of poplar seed fiber meant it had excellent sound absorption performance in the entire tested frequency range. The poplar seed fiber aggregate had a wide sound absorption frequency band and the maximum sound absorption coefficient reached 0.84, which has high application value in the field of sound absorption.
Master of Public Administration and Master of Public Policy degrees: Differences and similarities in the curricula and course contents
Authors: Morçöl Göktuğ , Tantardini Michele , Williams Adam , Slagle Derek R
Published: April 2020

The historical origins of public administration and public policy analysis suggest that Master of Public Administration and Master of Public Policy programs should have different focuses in their curricula: the former on management skills and the latter on analytical skills. To investigate whether and to what extent the two types of programs are different and whether the accreditation standards of the Network of Schools of Public Policy, Affairs, and Administration have a homogenizing effect on them, we investigated the titles and descriptions of the courses in their core curricula. The results show some differences between Master of Public Administration and Master of Public Policy programs, but no clear distinction. Analytical skills are required by both Master of Public Administration and Master of Public Policy programs. Master of Public Policy programs distinguish themselves from Master of Public Administration programs primarily by requiring economics and economic analysis courses. Higher percentages of Network of Schools of Public Policy, Affairs, and Administration-accredited programs require organization studies, human resource management, and public budgeting courses.
From reality disjunctions to dramatic reality: Bridging realities through the performance of life stories in dementia care
Authors: Novy Christine
Published: April 2020

This article explores the potential for a performative life story project to build bridges between different realities and, in so doing, to establish common ground between people who are living with dementia and members of their community. The discussion is anchored in a practice vignette from a single-case life story performance. Two features of the methodology, the ‘saying hullo again’ metaphor from narrative therapy and dramatic reality from drama therapy, are highlighted. Their combined effectiveness as an alternative framework for understanding and working with reality disjunctions in dementia care is discussed.
The Parallel Process - Dramatherapy sessions with an older non-verbal client
Authors: Sweet Rosie
Published: April 2020

An article outlining a case study examining a parallel process travelled by a dramatherapist and stroke victim. With all therapeutic relationships we embark on a journey with our client. This article examines just such a journey, one where the therapist and client moved together in a parallel process. These dramatherapy sessions were conducted with an older, non-verbal stroke victim and examine how the therapist experienced the transference changing through the therapy. This article explores work with a non-verbal individual with limited motor ability and how as dramatherapists we communicate with these individuals to create a therapeutic relationship and therefore meaningful therapeutic work.
Stress generation theory in couples with depression: A latent profile analysis
Authors: Morgan Preston , Dell’lsola Richard , Nicholson Bornell , Spencer Chelsea
Published: April 2020

Depressive symptoms and conflict negatively affect romantic relationships, but does this differ among couples? Using a stress generation theory framework, we aim to understand the types of profiles based on both partners’ responses of depressive symptoms and conflict. We used data from 1,598 German couples (different-sex) and conducted latent profile analyses in order to examine if there are different profiles of couples related to the male and female partners’ depressive symptoms and levels of conflict. We then examined if these profiles predicted relationship instability 1 year later. Our results revealed four profiles: congruent low conflict, incongruent female moderate conflict, incongruent male moderate conflict, and congruent moderate conflict. Both males and females in the congruent low and moderate conflict profiles showed agreement in their level of depressive symptoms and conflict, hence congruent. However, males and females differed in their levels of depressive symptoms and conflict in two incongruent profiles. For example, females in the incongruent female moderate conflict profile had higher levels of depressive symptoms and conflict than their partners. Prior depressive symptoms and conflict increased the odds of being in the incongruent female moderate conflict, incongruent male moderate conflict, and congruent moderate conflict profiles compared to the congruent low conflict profile. The congruent moderate conflict profile had the highest probability of relationship instability 1 year later. This study adds to our knowledge about the different profiles of couples with depressive symptoms and conflict as well as relationship instability.
Holding on and letting go: Memory, nostalgia, and effects of virtual possession management practices on post-breakup adjustment
Authors: Brody Nicholas , LeFebvre Leah , Blackburn Kate
Published: April 2020

When people end their relationships, they must choose which parts of the relationship to remember and forget as they prepare themselves for future partners. This memory process is complicated by the recordability and permanence of mediated messages because individuals must actively curate their virtual possessions—such as pictures with a previous partner or online relationship statuses. Using the relational dissolution model framework, this study investigated the behaviors people use online to manage the end of their relationships and how these choices may influence the way they adjust to the breakup. College students ( N = 234) were surveyed to examine how their keeping and deleting of virtual possessions are related to their post-breakup adjustment. Results suggest that keeping virtual possessions negatively relates to post-breakup adjustment. Participants who were more nostalgic were more likely to keep virtual possessions following a breakup, which mediated the relationship between nostalgia and post-breakup adjustment. The implications show how the persistence of mediated possessions has the potential to affect the breakup process as people struggle to manage their relational memories.
How short is too short? A randomised controlled trial evaluating short-term existential behavioural therapy for informal caregivers of palliative patients
Authors: Kühnel Martina B , Marchioro Linda , Deffner Veronika , Bausewein Claudia , Seidl Hildegard , Siebert Sarah , Fegg Martin
Published: April 2020

Background:

Informal caregivers of palliative patients show higher levels of depression and distress compared with the general population. Fegg’s (2013) existential behavioural therapy was shortened to two individual 1-h sessions (short-term existential behavioural therapy).

Aim:

Testing the effectiveness of sEBT on psychological symptoms of informal caregivers in comparison with active control.

Design:

Randomised controlled trial.

Setting/participants:

Informal caregivers of palliative in-patients.

Methods:

The primary outcome was depression; secondary outcomes were anxiety, subjective distress and minor mental disorders, positive and negative affect, satisfaction with life, quality of life and direct health care costs. General linear mixed models allow several measurements per participant and change over time. Reasons for declining the intervention were investigated by Rosenstock’s Health Belief Model.

Results:

Overall inclusion rate was 41.0%. Data of 157 caregivers were available (63.1% females; mean age: 54.6 years, standard deviation (SD): 14.1); 127 participants were included in the main analysis. Participation in sEBT or active control was not significantly associated with post-treatment depression. Outcomes showed prevailingly significant association with time of investigation. Self-efficacy, scepticism of benefit of the intervention, belief of better coping alone and support by family and friends were significant factors in declining participation in the randomised controlled trial.

Conclusion:

Inclusion rate was tripled compared with a previously evaluated longer EBT group intervention. By shortening the intervention, inclusion rate was traded for effectiveness and the intervention could not impact caregivers’ psychological state. Early integration of sEBT and combination of individual and group setting and further study of the optimal length for caregiver interventions are suggested.
Economic evaluation of a combined screening and stepped-care treatment program targeting psychological distress in patients with metastatic colorectal cancer: A cluster randomized controlled trial
Authors: El Alili Mohamed , Schuurhuizen Claudia S.E.W , Braamse Annemarie M.J. , Beekman Aartjan T.F. , van der Linden Mecheline H. , Konings Inge R. , Dekker Joost , Bosmans Judith E.
Published: April 2020

Background:

Psychological distress is highly prevalent among patients with metastatic colorectal cancer.

Aims:

To perform an economic evaluation of a combined screening and treatment program targeting psychological distress in patients with metastatic colorectal cancer in comparison with usual care.

Design:

Societal costs were collected alongside a cluster randomized controlled trial for 48 weeks. A total of 349 participants were included.

Setting:

Participants were recruited from oncology departments at 16 participating hospitals in the Netherlands.

Methods:

Outcome measures were the Hospital Anxiety and Depression Scale and quality-adjusted life-years. Missing data were imputed using multiple imputation. Uncertainty was estimated using bootstrapping. Cost-effectiveness planes and cost-effectiveness acceptability curves were estimated to show uncertainty surrounding the cost-effectiveness estimates. Sensitivity analyses were performed to check robustness of results.

Results:

Between treatment arms, no significant differences were found in Hospital Anxiety and Depression Scale score (mean difference: –0.058; 95% confidence interval: –0.13 to 0.011), quality-adjusted life-years (mean difference: 0.042; 95% confidence interval: –0.015 to 0.099), and societal costs (mean difference: –1152; 95% confidence interval: –5058 to 2214). Cost-effectiveness acceptability curves showed that the probability of cost-effectiveness was 0.64 and 0.74 at willingness-to-pay values of €0 and €10,000 per point improvement on the Hospital Anxiety and Depression Scale, respectively. The probability that the intervention was cost-effective compared to usual care for quality-adjusted life-years was 0.64 and 0.79 at willingness-to-pay values of €0 and €20,000 per quality-adjusted life-year, respectively.

Conclusion:

The intervention is dominant over usual care, primarily due to lower costs in the intervention group. However, there were no statistically significant differences in clinical effects and the uptake of the intervention was quite low. Therefore, widespread implementation cannot be recommended.
Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis
Authors: Clarke Julian V , Suggs Julia M , Diwan Deepti , Lee Jin V , Lipsey Kim , Vellimana Ananth K , Zipfel Gregory J
Published: April 2020

Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) has been associated with numerous pathophysiological sequelae, including large artery vasospasm and microvascular thrombosis. The focus of this review is to provide an overview of experimental animal model studies and human autopsy studies that explore the temporal-spatial characterization and mechanism of microvascular platelet aggregation and thrombosis following SAH, as well as to critically assess experimental studies and clinical trials highlighting preventative therapeutic options against this highly morbid pathophysiological process. Upon review of the literature, we discovered that microvascular platelet aggregation and thrombosis occur after experimental SAH across multiple species and SAH induction techniques in a similar time frame to other components of DCI, occurring in the cerebral cortex and hippocampus across both hemispheres. We discuss the relationship of these findings to human autopsy studies. In the final section of this review, we highlight the important therapeutic options for targeting microvascular platelet aggregation and thrombosis, and emphasize why therapeutic targeting of this neurovascular pathology may improve patient care. We encourage ongoing research into the pathophysiology of SAH and DCI, especially in regard to microvascular platelet aggregation and thrombosis and the translation to randomized clinical trials.
Endoscopic endonasal open reduction for fractures of the frontal process of the maxilla
Authors: Meng Xiangming , Wen Qingbo , Gu Jianhong , Wang Yangyang
Published: April 2020

Objective

This study was performed to evaluate the clinical efficacy of endoscopic endonasal open reduction of fractures of the frontal process of the maxilla (FFPM).

Methods

We performed a retrospective study of patients who underwent endoscopic endonasal open reduction of FFPM from December 2013 to October 2018. The preoperative assessment included nasal endoscopy, computed tomography imaging, and three-dimensional craniofacial reconstruction. The clinical results were evaluated with a visual analog scale at 2 days and 1 year postoperatively.

Results

Thirty-two patients (25 male, 7 female) with an average age of 39 years were included in the study. All patients successfully underwent a surgical operation via the endoscopic endonasal approach with a nasal mucosal incision, and the nasal deformities were corrected. At the 1-year follow-up, six (18.8%) and 26 (81.2%) patients were somewhat satisfied and very satisfied with the aesthetic result, respectively, and five (15.6%) and 27 (84.4%) were somewhat satisfied and very satisfied with the functional result, respectively.

Conclusion

Endoscopic endonasal open reduction can be considered a reliable method for anatomical reduction of FFPM. This technology provides a viable choice for the treatment of FFPM.
Foxp3+ Regulatory T Cells Associated With CCL17/CCR4 Expression in Carcinomas of Dogs
Authors: Maeda Shingo , Nakazawa Maho , Uchida Mona , Yoshitake Ryohei , Nakagawa Takayuki , Nishimura Ryohei , Miyamoto Ryo , Bonkobara Makoto , Yonezawa Tomohiro , Momoi Yasuyuki
Published: April 2020

Regulatory T cells (Tregs) can be targeted in cancer immunotherapy. A previous study has shown that the chemokine CCL17 and the receptor CCR4 play a role in Treg recruitment in canine urothelial carcinoma. Here, we describe the association of tumor-infiltrating Tregs with CCL17/CCR4 expression in dogs with other carcinomas. In this study, we investigated 23 dogs with mammary carcinoma, 14 dogs with oral squamous cell carcinoma, 16 dogs with pulmonary adenocarcinoma, and 8 healthy control dogs. Immunohistochemistry showed that Foxp3+ Tregs and CCR4+ cells were increased in the tumor tissues of mammary carcinoma, squamous cell carcinoma, and pulmonary adenocarcinoma, when compared with the healthy tissues. The number of CCR4+ cells was associated with that of Foxp3+ Tregs. Double immunofluorescence labeling confirmed that most tumor-infiltrating Foxp3+ Tregs expressed CCR4. In vitro, canine carcinoma cell lines expressed CCL17 mRNA. Quantitative RT-PCR (reverse transcriptase-polymerase chain reaction) showed that CCL17 mRNA expression in canine carcinomas was increased approximately 10- to 25-fold relative to that of healthy tissues. These results suggest that the CCL17/CCR4 axis may drive Treg recruitment in a variety of canine carcinomas. CCR4 blockade may be a potential therapeutic option for tumor eradication through Treg depletion.
Equine Hoof Canker: Bovine Papillomavirus Infection Is Not Associated With Impaired Keratinocyte Differentiation
Authors: Apprich Veronika , Licka Theresia , Freiler Sabrina , Gabriel Cordula
Published: April 2020

Impaired keratinocyte differentiation has recently been suggested as a key event in equine hoof canker development. Koilocytotic appearance of keratinocytes, one of the most characteristic morphological alterations in hoof canker tissue, is also a common marker for papillomavirus (PV) infection, and bovine PV-1 and/or -2 (BPV-1/2) has previously been detected in equine canker patients. Therefore, the present study aimed to correlate the frequency and severity of koilocytotic keratinocytes with BPV detection in hoof canker samples. Hoof tissue of 5/18 canker-affected horses and 2/6 control horses tested positive for BPV-1/2 DNA using polymerase chain reaction. Thus, no association between the presence of BPV-1/2 papillomaviral DNA and koilocytotic appearance was found. Proteins associated with but not specific for PV infection were also investigated. Using immunohistochemistry, specific adhesion molecules (E-cadherin and β-catenin) and intermediate filaments (keratins 6 and 14) important for intact epidermal barrier function and keratinocyte differentiation were documented in control samples ( n = 6) and in hoof canker tissue samples ( n = 19). Altered expression patterns of intermediate filaments and adhesion molecules were demonstrated in canker tissue, confirming the importance of incomplete keratinocyte differentiation, as well as the crucial role of keratinocyte differentiation in hoof canker.
A Unique Treatment Approach for Orthodontic Correction of a Unilateral Maxillary Canine-Lateral Incisor Transposition with Contralateral Impacted Maxillary Second Premolar
Authors: Takane Vanashree , Nagaraj K. , Keshan Divya , Keluskar Kanhoba
Published: April 2020

Tooth transposition is an unusual form of positional interchange of two adjacent teeth. The maxillary canine is the most frequently involved tooth. This is a case report of a complete left maxillary canine transposition with lateral incisor and impacted right maxillary 2nd premolar. Careful planning of the orthodontic transposition correction was done, and teeth were followed meticulously to their normal positions.
Case Report: Orthosurgical Management of Skeletal Class III Malocclusion
Authors: Verma Sanjeev
Published: April 2020

VG, 25-year-old male, presented with c/c of forwardly placed lower jaw and history of unsatisfactory previous orthodontic treatment. Extraorally, the patient had asymmetrical face and concave profile, competent lips, positive lip step, and chin deviated toward left side by 2 mm. Intraorally, the patient had Angle’s class III type 3 malocclusion with an overjet of (–1) mm, overbite of 0%, and cross-bite wrt 12, 21. The patient was skeletal class III due to macrognathic and prognathic mandible with hypodivergent growth pattern, and proclined upper and retroclined lower incisors. The patient was managed orthosurgically with bimaxillary surgery (maxillary advancement 3 mm + mandibular setback 7 mm) after presurgical decompensation.

The case report discusses in detail the diagnosis and comprehensive management of the skeletal class III case.
Vancouver Declaration II on Global Headache Patient Advocacy 2019
Authors: Dodick David W , Ashina Messoud , Sakai Fumihiko , Grisold Wolfgang , Miyake Hitoshi , Henscheid-Lorenz Deborah , Craven Audrey , Ruiz de la Torre Elena , Koh Rachel , Reznik Nikita , Bance Lisa , Leroux Elizabeth , Edvinsson Lars ,   on behalf of the International Headache Society Global Patient Advocacy Coalition
Published: April 2020

In 2017, the International Headache Society convened a Global Patient Advocacy Summit (GPAS-1) to begin a collaborative effort involving patients, patient advocates, patient advocacy organizations, healthcare professionals, scientists, professional pain, neurology, and headache societies, pharmaceutical manufacturers, and regulatory agencies to advance issues of importance to patients affected by headache worldwide. In September 2019, the second Global Patient Advocacy Summit (GPAS-2) was convened to revisit issues from the inaugural meeting, assess the progress of the International Headache Society Global Patient Advocacy Coalition (IHS-GPAC) in meeting the goals set forth therein, and discuss strategies for achieving established goals and supporting future development. Short- and long-term mandates from the first Summit were realized, including publishing the Vancouver Declaration on Global Headache Patient Advocacy 2018, determining the governing and operational structures of the IHS-GPAC, and helping to facilitate the first World Federation of Neurology World Brain Day dedicated to migraine. Another short-term mandate, creating a unified advocacy strategy, was fulfilled by the Coalition’s decision to focus on encouraging support from employers and implementing employee support programs for people with migraine. To help execute the strategy, the Coalition is developing an employer engagement toolkit that will educate employers and employees about the impact of migraine in the workplace, reduce stigma directed toward employees with migraine, and facilitate the care of employees with migraine to reduce the burden of illness and improve workplace productivity. Coalition members will disseminate the toolkit and encourage the adoption of migraine workplace programs by employers worldwide. The Coalition has established an alliance with two global, multinational employers to expand migraine awareness and support among policy makers and other stakeholders around the world. The IHS-GPAC met many of the goals established at GPAS-1, and it has initiated a global strategy focused on the psychosocial and economic toll of headache disorders, especially migraine, in the workplace. Ongoing and future activities will explore a range of opportunities with employers and across the full spectrum of advocacy goals.
Identification of candidate proteomic markers in the serum of medication overuse headache patients: An exploratory study
Authors: Pellesi Lanfranco , Guerzoni Simona , Baraldi Carlo , Cainazzo Maria Michela , Pini Luigi Alberto , Bellei Elisa
Published: April 2020

Purpose of the study

The pathophysiological mechanism of medication overuse headache is uncertain; no distinctive markers have been described right now. The aim of this study was to conduct proteomic analyses on serum samples from patients with medication overuse headache and healthy individuals. Specifically, mono- (SDS-PAGE) and two-dimensional gel electrophoresis (2-DE) followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) were used to evaluate changes in serum proteins.

Main findings

By SDS-PAGE, four over-expressed bands were revealed in patients, compared to controls. 2-DE combined with LC-MS/MS analysis allowed confirmation of some proteins preliminarily detected by SDS-PAGE: Hemopexin, alpha-1-acid glycoprotein 1, apolipoprotein A4 and haptoglobin. Moreover, other differential proteins were isolated, mostly increased in MOH patients: Alpha-1-antitrypsin, immunoglobulin heavy constant alpha 1, retinol binding protein and transthyretin. Only one protein, immunoglobulin kappa constant, was decreased in the patients’ group.

Conclusions

The investigation of the serum proteome can offer a better understanding about biological mechanisms underlying medication overuse headache. Specifically, medication overuse headache shares some serum biochemical markers with chronic pain conditions. Further studies might uncover the relevance of these proteins in medication overuse headache.