bluuebunny/crossref_metadata_2025 huggingface dataset:
A model of bi-directional interactions between complementary learning systems for memory consolidation of sequential experiences
Authors: Howard Michael D. , Skorheim Steven W. , Pilly Praveen K.
Published: October 2022

The standard theory of memory consolidation posits a dual-store memory system: a fast-learning fast-decaying hippocampus that transfers memories to slow-learning long-term cortical storage. Hippocampal lesions interrupt this transfer, so recent memories are more likely to be lost than more remote memories. Existing models of memory consolidation that simulate this temporally graded retrograde amnesia operate only on static patterns or unitary variables as memories and study only one-way interaction from the hippocampus to the cortex. However, the mechanisms underlying the consolidation of episodes, which are sequential in nature and comprise multiple events, are not well-understood. The representation of learning for sequential experiences in the cortical-hippocampal network as a self-consistent dynamical system is not sufficiently addressed in prior models. Further, there is evidence for a bi-directional interaction between the two memory systems during offline periods, whereby the reactivation of waking neural patterns originating in the cortex triggers time-compressed sequential replays in the hippocampus, which in turn drive the consolidation of the pertinent sequence in the cortex. We have developed a computational model of memory encoding, consolidation, and recall for storing temporal sequences that explores the dynamics of this bi-directional interaction and time-compressed replays in four simulation experiments, providing novel insights into whether hippocampal learning needs to be suppressed for stable memory consolidation and into how new and old memories compete for limited replay opportunities during offline periods. The salience of experienced events, based on factors such as recency and frequency of use, is shown to have considerable impact on memory consolidation because it biases the relative probability that a particular event will be cued in the cortex during offline periods. In the presence of hippocampal learning during sleep, our model predicts that the fast-forgetting hippocampus can continually refresh the memory traces of a given episodic sequence if there are no competing experiences to be replayed.
A nomogram based on nutritional status and A2DS2 score for predicting stroke-associated pneumonia in acute ischemic stroke patients with type 2 diabetes mellitus: A retrospective study
Authors: Song Xiaodong , He Yang , Bai Jie , Zhang Jun
Published: October 2022

Background

Stroke-associated pneumonia (SAP) commonly complicates acute ischemic stroke (AIS) and significantly worsens outcomes. Type 2 diabetes mellitus (T2DM) may contribute to malnutrition, impair innate immunity function, and increase the probability of SAP occurrence in AIS patients. We aimed to determine early predictors of SAP in AIS patients with T2DM and to construct a nomogram specifically for predicting SAP in this population by combining the A2DS2 score with available nutrition-related parameters.

Methods

A total of 1,330 consecutive AIS patients with T2DM were retrospectively recruited. The patients were randomly allocated to the training (n = 887) and validation groups (n = 443). Univariate and multivariate binary logistic regression analyses were applied to determine the predictors of SAP in the training group. A nomogram was established according to the identified predictors. The areas under the receiver operating characteristic curve (AUROC) and calibration plots were performed to access the predictive values of the nomogram. The decision curve was applied to evaluate the net benefits of the nomogram.

Results

The incidence of SAP was 9% and 9.7% in the training and validation groups, respectively. The results revealed that the A2DS2 score, stroke classification, Geriatric Nutritional Risk Index, hemoglobin, and fast blood glucose were independent predictors for SAP. A novel nomogram, A2DS2-Nutrition, was constructed based on these five predictors. The AUROC for A2DS2-Nutrition (0.820, 95% CI: 0.794–0.845) was higher than the A2DS2 score (0.691, 95% CI: 0.660–0.722) in the training group. Similarly, it showed a better predictive performance than the A2DS2 score [AUROC = 0.864 (95% CI: 0.828–0.894) vs. AUROC = 0.763 (95% CI: 0.720–0.801)] in the validation group. These results were well calibrated in the two groups. Moreover, the decision curve revealed that the A2DS2-Nutrition provided an additional net benefit to the AIS patients with T2DM compared to the A2DS2 score in both groups.

Conclusion

The A2DS2 score, stroke classification, Geriatric Nutritional Risk Index, hemoglobin, and fast blood glucose were independent predictors for SAP in AIS patients with T2DM. Thus, the proposed A2DS2-Nutrition may be a simple and reliable prediction model for SAP occurrence in AIS patients with T2DM.
Insight into the incredible effects of microwave heating: Driving changes in the structure, properties and functions of macromolecular nutrients in novel food
Authors: Deng Xuan , Huang Haozhou , Huang Shengjie , Yang Ming , Wu Jing , Ci Zhimin , He Yanan , Wu Zhenfeng , Han Li , Zhang Dingkun
Published: October 2022

Microwave heating technology performs the characteristics of fast heating, high efficiency, green energy saving and easy control, which makes it deeply penetrate into the food industry and home cooking. It has the potential to alter the appearance and flavor of food, enhance nutrient absorption, and speed up the transformation of active components, which provides an opportunity for the development of innovation foods. However, the change of food driven by microwave heating are very complex, which often occurs beyond people's cognition and blocks the development of new food. It is thus necessary to explore the transformation mechanism and influence factors from the perspectives of microwave technology and food nutrient diversity. This manuscript focuses on the nutritional macromolecules in food, such as starch, lipid and protein, and systematically analyzes the change rule of structure, properties and function under microwave heating. Then, the flavor, health benefits, potential safety risks and bidirectional allergenicity associated with microwave heating are fully discussed. In addition, the development of new functional foods for health needs and future market based on microwave technology is also prospected. It aims to break the scientific fog of microwave technology and provide theoretical support for food science to understand the change law, control the change process and use the change results.
Compassionate de-escalation of life-sustaining treatments in pediatric oncology: An opportunity for palliative care and intensive care collaboration
Authors: Cuviello Andrea , Pasli Melisa , Hurley Caitlin , Bhatia Shalini , Anghelescu Doralina L. , Baker Justin N.
Published: October 2022

Context

Approximately 40%-60% of deaths in the pediatric intensive care unit (PICU) are in the context of de-escalation of life-sustaining treatments (LSTs), including compassionate extubation, withdrawal of vasopressors, or other LSTs. Suffering at the end of life (EOL) is often undertreated and underrecognized. Pain and poor quality of life are common concerns amongst parents and providers at a child’s EOL. Integration of palliative care (PC) may decrease suffering and improve symptom management in many clinical situations; however, few studies have described medical management and symptom burden in children with cancer in the pediatric intensive care unit (PICU) undergoing de-escalation of LSTs.

Methods

A retrospective chart review was completed for deceased pediatric oncology patients who experienced compassionate extubation and/or withdrawal of vasopressor support at EOL in the PICU. Demographics, EOL characteristics, and medication use for symptom management were abstracted. Descriptive analyses were applied.

Results

Charts of 43 patients treated over a 10-year period were reviewed. Most patients (69.8%) were white males who had undergone hematopoietic stem cell transplantation and experienced compassionate extubation (67.4%) and/or withdrawal of vasopressor support (44.2%). The majority (88.3%) had a physician order for scope of treatment (POST – DNaR) in place an average of 13.9 days before death. PC was consulted for all but one patient; however, in 18.6% of cases, consultations occurred on the day of death. During EOL, many patients received medications to treat or prevent respiratory distress, pain, and agitation/anxiety. Sedative medications were utilized, specifically propofol (14%), dexmedetomidine (12%), or both (44%), often with opioids and benzodiazepines.

Conclusions

Pediatric oncology patients undergoing de-escalation of LSTs experience symptoms of pain, anxiety, and respiratory distress during EOL. Dexmedetomidine and propofol may help prevent and/or relieve suffering during compassionate de-escalation of LSTs. Further efforts to optimize institutional policies, education, and collaborations between pediatric intensivists and PC teams are needed.
The staging performance of a modified tumor-node-metastasis staging system incorporated with lymphovascular invasion in patients with esophageal squamous cell carcinoma
Authors: Zhuang Weitao , Wu Hansheng , Chen Rixin , Ben Xiaosong , Huang Shujie , Zhou Zihao , Wu Junhan , Tang Yong , Qiao Guibin
Published: October 2022

Background

Lymphovascular invasion (LVI) is recognized as an unfavorable prognostic factor for many solid tumors. However, its staging value has not been adequately illustrated in esophageal squamous cell carcinoma (ESCC).

Methods

The clinicopathologic relevance and prognostic impact of LVI were retrospectively analyzed in 822 patients with surgically treated ESCC. Univariate and multivariate analyses were used to determine the independent prognostic factors. Subgroup analyses stratified by pathological stages, nodal status and invasive depth were conducted using Kaplan–Meier method and log-rank test. Multiple staging models based on overall survival (OS) were constructed using Cox regression and evaluated by Harrell’s concordance index (C-index), integrated discrimination improvement (IDI), and net reclassification index (NRI).

Results

LVI was detected in 24.6% of ESCC patients, and its prevalence increased with a higher pathological stage (p < 0.001). In multivariate analysis, LVI was found to be an independent prognostic factor for OS [Hazard ratio (HR) = 1.545, 95% CI, 1.201–1.986), and was associated with unfavorable outcomes in stage I to III ESCC, regardless of nodal status and invasive depth. The staging model that incorporated LVI as an independent factor achieved the greatest improvement in accuracy (ΔC-index: 2.9%), and the greatest added value (IDI 2.8%, p < 0.01; NRI 13.7%, p < 0.05) for prediction of OS in ESCC patients.

Conclusions

LVI can facilitate further survival stratification in ESCC patients. The adoption of LVI as an independent staging factor in the current cancer staging system should be considered and further validated.
Progress of phototherapy for osteosarcoma and application prospect of blue light photobiomodulation therapy
Authors: Yang Jiali , Fu Qiqi , Jiang Hui , Li Yinghua , Liu Muqing
Published: October 2022

Osteosarcoma (OS) is the most common primary malignant bone tumor that mainly affects the pediatric and adolescent population; limb salvage treatment has become one of the most concerned and expected outcomes of OS patients recently. Phototherapy (PT), as a novel, non-invasive, and efficient antitumor therapeutic approach including photodynamic therapy (PDT), photothermal therapy (PTT), and photobiomodulation therapy (PBMT), has been widely applied in superficial skin tumor research and clinical treatment. OS is the typical deep tumor, and its phototherapy research faces great limitations and challenges. Surprisingly, pulse mode LED light can effectively improve tissue penetration and reduce skin damage caused by high light intensity and has great application potential in deep tumor research. In this review, we discussed the research progress and related molecular mechanisms of phototherapy in the treatment of OS, mainly summarized the status quo of blue light PBMT in the scientific research and clinical applications of tumor treatment, and outlooked the application prospect of pulsed blue LED light in the treatment of OS, so as to further improve clinical survival rate and prognosis of OS treatment and explore corresponding cellular mechanisms.
Case report: Primary intracranial EWs/PNET in adults: Clinical experience and literature review
Authors: Hu Xianwen , Huang Qi , Wang Ju , Li Dandan , Wang Pan , Cai Jiong
Published: October 2022

Introduction

Adult primary intracranial Ewing sarcomas (EWs)/primitive neuroectodermal tumors (PNETs) are extremely rare, with only 30 patients published before us. The imaging features and treatment strategies of primary intracranial EWs/PNETs are unclear due to its rarity. The aim of this study was to investigate the clinical features, imaging findings, treatment, survival analysis, and prognosis of adult EWs/PNETs, and a systematic review was conducted based on the patient we treated and published literature.

Case description

A 19-year-old male patient suffered from head pain due to an accidental fall on a motorcycle that occurred more than 10 days before going to the hospital, and underwent computed tomography (CT) examination; it was found that the left temporo-occipital fossa was occupied. Magnetic resonance imaging (MRI) was recommended to understand the nature of the lesion, and the result showed that it has a high probability of being a meningioma. He underwent surgical removal of the mass under general anesthesia, and surprisingly, postoperative pathology revealed EWs/PNET. The disease has a high degree of malignancy, and the patient developed multiple metastases throughout the body 5 years after surgery.

Conclusion

Primary intracranial EWs/PNETs in adult patients are rare, of which imaging findings should be considered as one of the differential diagnoses of meningioma, hemangiopericytoma, and malignant triton tumor. Larger solid-cystic masses with septum-like enhancement may be relatively specific imaging findings of intracranial EWs/PNETs. The prognosis of primary adult intracranial EWs/PNETs is poor. Radical tumor resection combined with radiotherapy and chemotherapy is currently the main and possibly the most effective treatment method.
Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases
Authors: Goemanne Sophie , Tilmanne Anne , Biarent Dominique , Smeesters Pierre , Simoni Paolo , Mahadeb Bhavna Ansuya , Vicinanza Alfredo
Published: October 2022

Background

Staphylococcus aureus is a well-known bacterium associated with carriage and responsible for different types of infections. The Panton-Valentine leucocidin (PVL) is a key virulence factor causing tissue necrosis. PVL can, however, be present in both benign and life-threatening infections.

Case reports and management

We present three pediatric severe infections occurring over a period of only three weeks, in February 2021, and caused by genetically unrelated methicillin-sensitive Staphylococcus aureus producing PVL in a tertiary children’s hospital in Belgium. The first one presented with necrotizing pneumonia, the second one with a neck abscess extended to the mediastinum, and the last one had sacral osteomyelitis complicated by endocarditis. The management of these infections is mostly based on expert opinions. The most appropriate treatment seems to be the combination of early surgical drainage of infected collections with an antibiotic regimen associating two antibiotics; beta-lactams and either clindamycin or linezolid. Human immunoglobulins also appear to be useful as adjunctive therapy.

Conclusion

PVL-producing Staphylococcus aureus is associated with life-threatening infections in children. Prompt management is needed including surgery and appropriate antibiotic regimens.
Children with trisomy 21 are a group at risk for severe COVID-19: Case reports from a COVID-19 treatment unit in Addis Ababa, Ethiopia
Authors: Alemayehu Tinsae , Buonsenso Danilo
Published: October 2022

Trisomy 21 (Down syndrome) is a chromosomal disorder associated with humoral and cellular immunologic impairments among other systemic manifestations. It occurs at a frequency of 1 in 750 live births. There are increasing reports of children with Down syndrome presenting signs of severe COVID-19. The literature from Africa on pediatric COVID-19 and risk stratification for severe disease is scant. A summary of the clinical features, complications, and treatment outcomes of three Ethiopian children with Trisomy 21 and severe COVID-19 along with a discussion of the correlation between trisomy 21 immunology and severe SARS CoV-2 infection is presented.
Trifluridine/tipiracil as a therapeutic option in real life setting of metastatic colorectal cancer: An efficacy and safety analysis
Authors: Sur Daniel , Lungulescu Cristina , Spînu Ștefan , Gorzo Alecsandra , Dumitrescu Elena-Adriana , Gheonea Dan Ionut , Lungulescu Cristian-Virgil
Published: October 2022

Background: In the phase III RECOURSE trial, the orally administered combination trifluridine/tipiracil (FTD/TPI) demonstrated a survival benefit and an acceptable safety profile, earning approval as a third-line therapy in metastatic colorectal cancer (mCRC). This study aimed to assess the efficacy and safety of FTD/TPI in daily clinical practice in Romanian population.

Methods: A single-center, retrospective, and observational study analyzed patients with mCRC that received chemotherapy with trifluridine/tipiracil between May 2019 and May 2022 at the Oncology Institute Prof. Dr. Ion Chiricuță in Cluj-Napoca, Romania. Study endpoints included safety, and median progression-free survival (PFS).

Results: In this Romanian cohort (n = 50) the most common treatment-emergent adverse event was haematological toxicity (76%): anemia (50%), leucopenia (38%), neutropenia (34%), and thrombocytopenia (30%), followed by fatigue (60%), and abdominal pain (18%). Overall, the median progression-free survival was 3.85 months (95% CI: 3.1–4.6 months). PFS was significantly correlated with the number of FTD/TPI administrations and prior surgery.

Conclusion: Our study corroborated the previously described safety profile for FTD/TPI in the third-line setting, and demonstrated relatively superior mPFS.
MPDNet: A Transformer-based real-time passenger detection network in metro stations
Authors: Yang Jun , Gong Mengjie , Dong Xueru , Liang Jiahua , Wang Yan
Published: October 2022

We propose a passenger flow detection method for dense areas of subway stations to address the current situation that existing pedestrian detection models cannot meet the real-time performance requirements in subway applications and lack validation in multiple subway scenarios. First, we designed the MPDNet model, which uses PVT-small to extract features and an improved feature pyramid network (FPN) for upsampling using the adaptively spatial feature fusion (ASFF) algorithm to retain more local information in the output of the FPN. Second, to better evaluate the performance of models in the metro, we collected subway surveillance video data and proposed the MetroStation dataset. Finally, we trained and evaluated the performance of the MPDNet model on the MetroStation dataset. We compare our method with several common object detection models on the MetroStation dataset, using mAP and frames per second (FPS) to verify its accuracy. The experiments on the MetroStation dataset demonstrated that the MPDNet performed well and satisfied inference speed requirements in metro passenger flow detection.
Blood flow restriction training promotes functional recovery of knee joint in patients after arthroscopic partial meniscectomy: A randomized clinical trial
Authors: Ke Junjie , Zhou Xuchang , Yang Yajing , Shen Hai , Luo Xiaobing , Liu Hui , Gao Lu , He Xin , Zhang Xin
Published: October 2022

Purpose: To explore the effect of blood flow restriction training (BFRT) on the recovery of knee function in patients after arthroscopic partial meniscectomy (APM).

Methods: Forty patients undergoing APM surgery were included in this parallel group, two-arm, single-assessor blinded, randomized clinical trial. The subjects were randomly divided into two groups: routine rehabilitation group (RR Group, n = 20) and routine rehabilitation + blood flow restriction training group (RR + BFRT Group, n = 20). One subject in each group dropped out during the experiment. All patients received 8 weeks of routine rehabilitation starting from the second day after APM. In addition, patients in the RR + BFRT group required additional BFRT twice a week. Visual analogue scale (VAS) score, range of motion (ROM), one-leg standing test (OLST) score, Lysholm knee score, quadriceps muscle strength, quadriceps thickness, and thigh circumference were evaluated at preoperative, postoperative, 4 and 8 weeks after surgery. SPSS 25.0 software was used for statistical analysis of the data. Repeated measures ANOVA was used if the data were normally distributed and had homogeneity of variance. Generalized estimating equations were chosen if the data were not normally distributed or had homogeneity of variance.

Results: There were no significant differences in VAS score, ROM, OLST score, Lysholm knee score, quadriceps muscle strength, quadriceps thickness, and thigh circumference between the two groups before surgery (p > 0.05). Compared with postoperative, VAS score, ROM, OLST score, Lysholm knee score, and thigh circumference were significantly improved in the RR group (p < 0.05), while quadriceps muscle strength and quadriceps thickness were not significantly enhanced at 8 weeks postoperatively (p > 0.05). However, VAS score, ROM, OLST score, Lysholm knee score, quadriceps muscle strength, quadriceps thickness, and thigh circumference were all significantly improved in the RR + BFRT group at 8 weeks postoperatively (p < 0.05). Furthermore, compared with the RR group, VAS score (50% vs. 86%), ROM (7.9% vs. 16.0%), OLST score (57.3% vs. 130.1%), Lysholm knee score (38.4% vs. 55.7%), relative peak torque (11.0% vs. 84.7%), mean power (20.6% vs. 88.1%), rectus femoris thickness (0.40% vs. 13.0%), vastus medialis (0.29% vs. 5.32%), vastus lateralis (0% vs. 6.2%), vastus internus (0% vs. 5.8%), and thigh circumference (2.7% vs. 5.8%) in the RR + BFRT group were significantly improved at 4 and 8 weeks postoperatively (p < 0.05).

Conclusion: BFRT combined with routine rehabilitation training can better promote the recovery of knee joint function in patients after APM, especially the improvement of quadriceps muscle strength and thickness.
Differential alternative splicing genes and isoform co-expression networks of Brassica napus under multiple abiotic stresses
Authors: Yang Lingli , Yang Li , Zhao Chuanji , Liu Jie , Tong Chaobo , Zhang Yuanyuan , Cheng Xiaohui , Jiang Huifang , Shen Jinxiong , Xie Meili , Liu Shengyi
Published: October 2022

Alternative splicing (AS) is an important regulatory process that affects plant development and stress responses by greatly increasing the complexity of transcriptome and proteome. To understand how the AS landscape of B. napus changes in response to abiotic stresses, we investigated 26 RNA-seq libraries, including control and treatments with cold, dehydration, salt, and abscisic acid (ABA) at two different time points, to perform comparative alternative splicing analysis. Apparently, AS events increased under all stresses except dehydration for 1 h, and intron retention was the most common AS mode. In addition, a total of 357 differential alternative splicing (DAS) genes were identified under four abiotic stresses, among which 81 DAS genes existed in at least two stresses, and 276 DAS genes were presented under only one stress. A weighted gene co-expression network analysis (WGCNA) based on the splicing isoforms, rather than the genes, pinpointed out 23 co-expression modules associated with different abiotic stresses. Among them, a number of significant hub genes were also found to be DAS genes, which encode key isoforms involved in responses to single stress or multiple stresses, including RNA-binding proteins, transcription factors, and other important genes, such as RBP45C, LHY, MYB59, SCL30A, RS40, MAJ23.10, and DWF4. The splicing isoforms of candidate genes identified in this study could be a valuable resource for improving tolerance of B. napus against multiple abiotic stresses.
Characterization and expression analysis of MATEs in Cannabis sativa L. reveals genes involving in cannabinoid synthesis
Authors: Wang Sifan , Cao Xue , Meng Xiangxiao , Aili Maimaiti , Dou Qin , Wang Yan , Wahab Atia Tul , Chen Shilin , Sun Wei , Wan Huihua , Chen Weiqiang
Published: October 2022

The medicinal plant Cannabis sativa L. (C. sativa) accumulates plant cytotoxic but medicinally important cannabinoids in glandular trichomes and flowers of female plants. Although the major biosynthetic pathway of cannabinoids has been revealed, their transportation mechanism is still unknown. Multidrug and toxic compound extrusion proteins (MATEs) can transport plant metabolites, ions and phytohormones intra and inter-cellularly. MATEs could have the potential to translocate cannabinoids or their synthetic intermediates to cellular compartment, thus protecting them from unwanted modifications and cytotoxicity. In this study, we performed a genome-wide identification and expression analysis of Cannabis sativa MATEs (CsMATEs) and revealed 42 CsMATEs that were classified phylogenetically into four conserved subfamilies. Forty-two CsMATEs were unevenly distributed on 10 chromosomes, with 50% CsMATEs were physically adjacent to at least one another CsMATEs and 83% CsMATEs localized on plasma membrane. Tandem duplication is the major evolutionary driving force for CsMATEs expansion. Real-time quantitative PCR revealed CsMATE23, CsMATE28 and CsMATE34 mainly expressed in flower, whereas CsMATE17 and CsMATE27 showed strong transcription in root. Light responsive cis-acting element was most abundant in promoters of CsMATE23, CsMATE28 and CsMATE34. Finally, the contents of cannabinoids and corresponding biosynthetic intermediates as well as expressions of CsMATE28 and CsMATE34 were determined under UV-B treatment, among which strong correlation was found. Our results indicates that CsMATEs might involve in biosynthesis of cannabinoids and has the potential to be used in heterologous production of cannabinoids.
Dark side of a bio-based and biodegradable plastic? Assessment of pathogenic microbes associated with poly(butylene succinate-co-adipate) under ambient and future climates using next-generation sequencing
Authors: Juncheed Kantida , Tanunchai Benjawan , Wahdan Sara Fareed Mohamed , Thongsuk Katikarn , Schädler Martin , Noll Matthias , Purahong Witoon
Published: October 2022

Bio-based and biodegradable plastic mulching films have been proposed to replace the non-biodegradable plastic mulch films to solve plastic pollution problems in agricultural soils. However, the impact of bio-based and biodegradable plastics on plant and human health remains largely unexplored. Here, we aimed to assess the risk under field conditions of a bio-based and biodegradable poly(butylene succinate-co-adipate; PBSA), a widely used mulching film as carrier of potential pathogenic microorganisms (bacteria and fungi) at ambient and future climate conditions. Overall, we affiliated 64 fungal and 11 bacterial operational taxonomic units (OTUs) as pathogens by using Next-Generation Sequencing approach. Our results revealed that PBSA hosted at least 53 plant pathogens, of which 51 were classified as fungi, while the other two were bacteria. Most fungal plant pathogens were able to withstand the anticipated future climate changes. We detected 13 fungal and eight bacterial OTUs, which were classified as opportunistic human pathogens. Only one bacterial OTU (Enterococcus faecium) was assigned to a human pathogen. While future climate conditions only significantly impacted on the presence and frequency of detection of few pathogens, incubation time was found to significantly impacted on nine pathogens. This result demonstrates the temporal dynamics of pathogens associated with PBSA. The threats to plant and human health were discussed. We emphasize that the risks to human health are relatively low because we mainly found opportunistic pathogens associated with PBSA and the amount are comparable to the plant debris. However, the risks to plant health may be considered as moderate because many plant pathogens were discovered and/or enriched in PBSA. Furthermore, in soil environments, the pathogenic risk of plastic is highly depending on the surrounding soil pathobiome where plastic is being decomposed.
Dynamics and correlations of chlorophyll and phytol content with silage bacterial of different growth heights Pennisetum sinese
Authors: Li Mao , Lv Renlong , Zhou Hanlin , Zi Xuejuan
Published: October 2022

The dynamics and correlations of chlorophyll and phytol content with silage bacterial of different growth heights Pennisetum sinese were investigated. The results demonstrated that the chlorophyll and phytol content of P. sinese before and after ensiled decreased with the increase of growth height. Ensiling significantly reduced pigment content but had no significant effect on phytol. In addition, P. sinese pigment yield before and after ensiled increased with growth heights increasing, and the yield at 150 or 180 cm was obviously higher. Moreover, the higher silage quality V-Score were at 150 or 180 cm growth heights. Furthermore, the silage microbial diversity were varied by growth heights, and some specific undesirable microorganisms (Acinetobacter, Cellvibrio, Sphingobacterium, etc.) were negatively correlated with pigment and phytol content. Therefore, with comprehensive consideration of pigment, phytol yield, and silage quality, the optimum harvest growth height of P. sinese was 150 cm. Furthermore, precise reduction of particular undesirable microorganisms maybe helps to preserve pigments and phytol.
The validation of the Norwegian Basic Psychological Need Satisfaction and Frustration Scale: A stratified sampling procedure
Authors: van der Kaap-Deeder Jolene , Sanchez Alba , Johannessen Maria Regine Aasland , Stenseng Frode , Saksvik-Lehouillier Ingvild , Heissel Andreas
Published: October 2022

This study aimed to validate the Norwegian version of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) and to examine its relations with indicators of well-being and ill-being. Additionally, despite the vast number of studies employing the BPNSFS, norms related to the BPNSFS are currently lacking. Therefore, we also aimed to provide normative data for this scale. Data were collected among a representative sample of 326 participants (Mage = 42.90 years,SD = 14.76; range 18–70) in Norway, of which 49.7% was female. Results yielded evidence for a six-factor structure (i.e., combining satisfaction/frustration with the type of need) and showed the subscales to be highly reliable. Subsequent structural equation modeling showed that both need satisfaction and need frustration related strongly to vitality, life satisfaction, and internalizing symptoms, but in opposite ways. Norm scores were provided, thereby differentiating between women and men and different age groups. These findings support the use of the Norwegian BPNSFS and provide researchers and professionals with normative data on the most widely used tool to assess individuals’ satisfaction and frustration of the basic psychological needs for autonomy, competence, and relatedness.
Effects of multimedia integrated fine arts education on students' learning attitude and learning satisfaction
Authors: Sun Xiaodong , Fu Rong , Zhang Guoqing , Chen Chenin
Published: October 2022

The educational reform of the twenty-first century was a successful attempt in which high technology, media, and multimedia computer information work together. The use of instructional media doubled the effect with half the effort in promoting learners' motivation to learn. This was achieved by providing specific and authentic information, changing attitudes, and even being independent of instruction. The rapid development of technology also brings innovations in teaching media. The purpose of this study is to investigate the effects of multimedia integrated fine arts education on students. A quasi-experimental design was adopted in this study. College students from Shanxi Province were selected as the participants of a one-semester experimental study. The research results show significantly positive effects of (1) multimedia integrated fine arts education on learning attitude, (2) multimedia integrated fine arts education on learning satisfaction, and (3). mobile learning on learning satisfaction. The experimental observation revealed that, when fine arts works are exhibited through multimedia, students have closer contact with them. Students gradually feel more involved in art and show interest in art, as well as a desire to explore. Such a process of change will enable students to change their learning attitude into active absorption of professional knowledge of fine arts. As a result, their competence in fine arts can be improved significantly. It is expected that the results will contribute to the fine arts and humanities with practically tested theories as a reference for teachers and future studies in the field.
Psychometric properties of the Collective Efficacy Scale Short-Form in Chilean teachers
Authors: Herrera Camilo , Torres-Vallejos Javier , Martínez-Libano Jonathan
Published: October 2022

Background

The Collective Efficacy Scale Short-Form (CES-SF) is a short and reliable instrument that assesses collective efficacy in schools at a group level. Previous research has shown a two-factor structure considering the perception of the group competence about their teaching capabilities and task analysis that refers to the opportunities inherent to a specific task. However, there is no conclusive evidence that collective efficacy corresponds to a two-factor model or single-factor structure.

Methods

A cross-sectional research was conducted on a 693 sample of teachers (Mage = 39.4; SD = 11.8) from schools in the 16 regions of Chile. They were assessed using the CES-SF, Personal Well-being Index, Social Well-Being Scale, and satisfaction with the school. Exploratory and confirmatory factor analyses were used to assess the construct validity of the CES-SF.

Results

The CES-SF showed mixed results about its construct validity. Best fit has been found to retain two new factors (opportunities and challenges for collective efficacy) with eight items each, yielding a McDonald’s ω of 0.803. Convergent validity was also established.

Conclusion

The psychometric results suggest that a two-factor structure for the CES-SF is a valid and reliable measure for this construct for Chilean teachers. However, collective efficacy might not strongly relate to subjective wellbeing but to school-context variables.
Illumination and gaze effects on face evaluation: The Bi-AGI database
Authors: Mattavelli Giulia , Gorrino Irene , Cesana Elisabetta , De Angelis Jacopo , Ricciardelli Paola
Published: October 2022

Face evaluation and first impression generation can be affected by multiple face elements such as invariant facial features, gaze direction and environmental context; however, the composite modulation of eye gaze and illumination on faces of different gender and ages has not been previously investigated. We aimed at testing how these different facial and contextual features affect ratings of social attributes. Thus, we created and validated the Bi-AGI Database, a freely available new set of male and female face stimuli varying in age across lifespan from 18 to 87 years, gaze direction and illumination conditions. Judgments on attractiveness, femininity-masculinity, dominance and trustworthiness were collected for each stimulus. Results evidence the interaction of the different variables in modulating social trait attribution, in particular illumination differently affects ratings across age, gaze and gender, with less impact on older adults and greater effect on young faces.
Terrorism and the internet: How dangerous is online radicalization?
Authors: Binder Jens F. , Kenyon Jonathan
Published: October 2022

This work is concerned with the extent and magnitude of threat related to online radicalization in the context of terrorist acts and related offending. Online influences have been depicted as major drivers for the propagation and adoption of extremist ideologies, which often contain an element of collective grievance, and subsequent acts of violence. This is most pronounced in the discussion of so-called lone actor terrorism, but extends to all forms of extremist offending, and beyond. The present work situates online radicalization leading to terrorist acts within the wider context of grievance-based beliefs and attitudes. Further, it addresses current positions and debates surrounding the relevance and mechanisms of online radicalization in terrorist offending. Recent evidence from quantitative studies is reviewed to estimate prevalence of online radicalization and the level of threat that results from it. This is followed by a discussion of plausible, but opposing, interpretations of the estimates presented. While online radicalization does occur, with and without reference to offline processes, the resulting threat is not overly high. This assessment, however, refers to the present only and is unlikely to hold for the future, given the general growth and acceleration of online activity among terrorist actors.
Implementation and evaluation in low intensity intervention programs from the CONNECT perspective of mixed methods: Application in a case of an autistic child
Authors: Arias-Pujol Eulàlia , Mestres Marina , Miralbell Júlia , Bachs Natalia , Anguera M. Teresa
Published: October 2022

There has been a comprehensive development over the last few years of low intensity intervention programs that are implemented within a user context and that are made up of everyday life activities, and it has been necessary to adapt the necessary methodological channels in order to guarantee an adequate resolution pathway. The mixed method perspective offers a suitable framework, and observational methodology – in itself considered mixed method – is appropriate for studying the implementation and evaluation of low intensity intervention programs, allowing the development of the QUAL-QUAN-QUAL stages that correspond to the connect integration pathway of mixed methods. In this work it was applied to a single case, in a low intensity intervention, retrieving valuable information obtained, but systematizing it and applying quantitizing to the qualitative data that was treated quantitatively in a rigorous manner. The aim was to analyze the psychotherapist-patient interaction in psychoanalytic psychotherapy, in which we sought to identify which of the therapist’s techniques stimulated actions of reciprocal social interaction in the child, and which techniques inhibited non reciprocal social interactions. The observational design was nomothetic, follow-up, and multidimensional. The patient was a 4-year-old boy with a diagnosis of severe autism spectrum disorder. We used an ad hoc observation instrument combining a field format and a category system. Interobserver agreement was analyzed quantitatively by Cohen’s kappa using the free QSEQ5 software program. Polar coordinate analysis was carried out using the free program HOISAN 2.0. Polar coordinate analysis allows us to obtain an inter-relational map of the connections detected between focal behavior established in each case and the different categories. The results provide objective evidence – backed up by the application of polar-coordinate-based data analysis – that within a framework of psychoanalytic psychotherapy, the techniques of “verbalization” and “vocalization” significantly activate reciprocal social interaction behaviors and inhibit non-social reciprocal behaviors in a child with severe autism spectrum disorder with no language. On the other hand, direct gaze promotes the child’s withdrawal. The results are of key importance as they show the therapist behaviors most useful for promoting social interaction in a child with severe autism.
Profiles and factors associated with schizophrenia in eastern Ethiopia: A matched case-control study
Authors: Mohammed Fethia , Geda Biftu , Yadeta Tesfaye Assebe , Dessie Yadeta
Published: October 2022

Background

Despite its strong hereditary and genetic connections, there are other factors reported to be linked to schizophrenia, but not well studied in eastern Ethiopia.

Objective

This study was aimed to investigating the potential profiles and factors associated with schizophrenia in eastern Ethiopia.

Materials and methods

A matched case-control study was conducted in two public hospitals from December 1, 2021, to January 30, 2022. Cases were patients with schizophrenia who visited the hospitals, and controls were healthy individuals without any mental illness who visited the same hospitals. A questionnaire was used to collect the data. Cases and controls were matched using age and sex. STATA-14 was used for analysis. A conditional logistic regression with an adjusted odds ratio (AOR) and a 95% confidence interval (CI) was applied to identify the determinants. P-values of <0.05 were used to build the final model as a measure of statistical significance.

Results

The mean age of the study participants group was 28.6 (±8.44) years, mean age for cases was 28.7(±8.5) ranging from 18 to 56 years and the mean age for the controls was 28.4 (±8.5), ranging from 18 to 60 years. About 181 (83.03%) of the participants were male. The odds of having schizophrenia was about 12.2 times higher among participants with family history of mental illness (AOR: 12.21; 95% CI: 4.83–30.00). The odds of having schizophrenia was 4.5 times higher among polysubstance users (AOR: 4.45; 95% CI: 1.28–5.45) and 2.8 times higher among khat consumers (AOR: 2.82; 95% CI: 1.23–6.45) compared to their counterparts.

Conclusion

Our findings show that genetic risk factors as well as some modifiable behaviors are associated to schizophrenia in eastern Ethiopia. At all levels, special attention should be given to those who are at risk.
Distinct alterations of functional connectivity of the basal forebrain subregions in insomnia disorder
Authors: Jiang Guihua , Feng Ying , Li Meng , Wen Hua , Wang Tianyue , Shen Yanan , Chen Ziwei , Li Shumei
Published: October 2022

Background

Cholinergic basal forebrain (BF) plays an important role in sleep-wake regulation and is implicated in cortical arousal and activation. However, less is known currently regarding the abnormal BF-related neuronal circuit in human patients with insomnia disorder (ID). In this study, we aimed to explore alterations of functional connectivity (FC) in subregions of the BF and the relationships between FC alterations and sleep and mood measures in ID.

Materials and methods

One hundred and two ID patients and ninety-six healthy controls (HC) were included in this study. Each subject underwent both resting-state fMRI and high-resolution anatomical scanning. All participants completed the sleep and mood questionnaires in ID patients. Voxel-based resting-state FC in each BF subregion (Ch_123 and Ch_4) were computed. For the voxel-wise FC differences between groups, a two-sample t-test was performed on the individual maps in a voxel-by-voxel manner. To examine linear relationships with sleep and mood measures, Pearson correlations were calculated between FC alterations and sleep and mood measures, respectively.

Results

The ID group showed significantly decreased FC between the medial superior frontal gyrus and Ch_123 compared to HC. However, increased FC between the midbrain and Ch_4 was found in ID based on the voxel-wise analysis. The correlation analysis only revealed that the altered FC between the midbrain with Ch_4 was significantly negatively correlated with the self-rating anxiety scale.

Conclusion

Our findings of decreased FC between Ch_123 and medial superior frontal gyrus and increased FC between midbrain and Ch4 suggest distinct roles of subregions of BF underlying the neurobiology of ID.
Study protocol—Evoked craving in high-dose benzodiazepine users
Authors: Zamboni Lorenzo , Toldo Silvia , Fusina Francesca , Mattiello Matteo , Mannari Vanessa , Campagnari Simone , Schiavone Valentina , Congiu Alessio , Verlato Giuseppe , Chiamulera Cristiano , Lugoboni Fabio
Published: October 2022

Benzodiazepine (BDZ) abuse, especially concerning high doses of BDZs, is an impairing substance use disorder (SUD) that is often difficult to treat. Craving and cue reactivity (CR) are two important phenomena that have a prominent role in maintaining addiction and triggering relapses in BDZ abuse; nevertheless, they have rarely been addressed in scientific literature. The present study aims to fill these gaps by implementing a highly innovative virtual reality (VR) design to assess the impact of substance-related environmental cues on BDZ craving, as well as their influence on patients’ affective states. Therefore, on one hand, this research will contribute to the assessment of VR feasibility in the study of these phenomena, and, on the other, it will help disentangle the role that CR and craving have on mood and attention, which are equally important factors to consider when treating SUDs. We will recruit a healthy control group and a patient group comprising people seeking treatment for BDZ detoxification. The experimental design will consist of the presentation of three VR scenarios, one neutral, one BDZ-related but without BDZ cues, and another with BDZ cues. The craving will be measured through a virtual analog scale (VAS); the Profile of Mood States (POMS) and Alcohol Attention Scale (AAS) questionnaires in a modified version will also be administered. We will additionally control for VR-induced feelings of sickness by administering the Simulator Sickness Questionnaire (SSQ), and the Presence Questionnaire (PQ) will be used to investigate participants’ sense of presence in virtual environments. We expect patients to exhibit higher levels of craving, and that the craving will be higher after exposure to a cue-related virtual environment as compared to a neutral scenario.