bluuebunny/crossref_metadata_2025 huggingface dataset:
Individual responsobility for health: patterns of behavior
Authors: Zhuravleva Irina , Petrenko Elena
Published: June 2023

The article discusses the ambiguity of the phenomenon of “responsibility for health” and its relevance in modern life as an important potential for improving the health of the population. Its significance is due to the approved “Strategy for the formation of a healthy lifestyle of the population, prevention and control of non-infectious diseases for the period until 2025.” The structure of the multicomponent phenomenon of “responsibility for health” is being considered based on the materials of the study “Care for health” by Public Opinion Fund (2019) using the locus of control as a psychological tool that made it possible to detect fundamental differences between the positions of individuals who maintain a responsible attitude to health and those who have the opposite point of view. Behavioural practices related to health care, types of motivation, basic environmental and informational factors are considered. It is concluded that a person’s life position in relation to health correlates not only with self-assessment of health, life satisfaction, but also with the level of education, financial and official position, and even place of residence. This psychological orientation affects not only health, but all aspects of human life. Taking into account the important role of the individual in the formation of his attitude to health, it is necessary to create conditions for the implementation of patterns of behaviour of a positive orientation on the basis of the required motivation. A number of social measures are proposed for the active inclusion of the individual in the process of strengthening, maintaining health and taking responsibility for it.
Emergency volunteering: modern problems and development prospects
Authors: Grechanaya Anna , Orlov Dmitry
Published: June 2023

The article presents the results of a review of studies conducted in the period from 2020 to 2022 in the field of emergency volunteering. The purpose of the review is to identify relevant areas of research, describe the characteristics of rescue volunteers and the specifics of the work of volunteer organisations operating in the field of public safety. Particular attention was paid to the use of new digital and technical means in the work of volunteers. Rescue volunteering is the most specialised and skill-rich volunteering activity, and is also involves significant health risks, both physical and psychological. In this regard, the conclusion identified the main barriers to the development of emergency volunteering in Russia. The most pronounced and frequently raised topic remains the problem of effective interaction and competent communication between volunteers and employees of state rescue services.
Extraction of Phenolic Active Compounds from Coffee Leaves (Coffea sp.) Using the Ultrasound Assisted Extraction Method and Total Phenol Analysis
Authors: Alfinaini Nur Aini Dwi Alfinaini , Boy Arief Fachri  , Pratamai Shelli  , Helda Wika Amini  , Istiqomah Rahmawati
Published: June 2023

Coffea sp. is one of the largest plantation commodities in Indonesia, especially coffee leaf waste contains phenolic compounds. This research was conducted to extract phenolic compounds using the Ultrasound-Assisted Extraction method with ethanol as a solvent. In addition, this study aims to determine the optimum operating conditions for extraction and the effect of variations in the amplitude, time and ratio of the resulting solvent. The experimental design was carried out using Design Expert 13 software with the response surface method box-behnken design. The research variables used were amplitude variations (50%, 60%, and 70%), time (10, 20, and 30 minutes), and solvent ratios (0.1; 0.15; and 0.2 g/mL). ). Based on the research that has been done, the extraction parameters of coffee leaves affect the total phenolic content. The model equation for the total phenolic content of coffee leaves obtained is Y = 0.1349 – 0.0016 A – 0.0505 B + 0.0010 C + 0.0018 AB + 0.0043 AC – 0.0018 BC – 0.0004 A2 + 0.0178 B2 – 0.0014 C2 (R2 = 0.9758) with the optimum total phenolic content located in the 17th running of 0.209 mg GAE/g under conditions of 20 minutes, the ratio of material to solvent is 0.2 g/mL, and an amplitude of 50%.
PENGARUH DAYA LAMPU ULTRAVIOLET LIGHT EMITTING DIODE (LED) GROWTH TERHADAP PERTUMBUHAN FISIKA TANAMAN SELADA SISTEM HIDROPONIK
Authors: Zakiyah Elisha , Prihandono Trapsilo , Yushardi Yushardi
Published: June 2023

Lettuce is a horticultural crop that has many enthusiasts and is widely cultivated using hydroponic systems. One important factor for plant growth is the need for sufficient light to support the process of photosynthesis. Efforts to overcome the lack of light is to use artificial light that comes from LED lights. This study aims to determine the effect of ultraviolet LED growth lamp power on the growth of lettuce plants. This study was divided into two groups: the control group without irradiating LED growth lamps and the experimental group using irradiation of LED growth lamps with a duration of irradiation of 4 hours at night. Parameters observed included plant height, leaf length, leaf width, number of leaves and leaf color in the third week. Analysis of research data used a non-parametric statistical test, namely the Kruskal Wallis test with the help of SPSS 23. The results showed that the power treatment of LED growth lamps had a significant effect on plant height, leaf length, leaf width and number of leaves. However, the power treatment of LED growth lamps did not significantly affect leaf color. The results showed that the best treatment was obtained at 18 watts of power.
Fan fiction jako współczesna forma publikowania. Próba charakterystyki zjawiska z punktu widzenia komunikacji sieciowej
Authors: Pałosz Justyna
Published: June 2023

Zarys zjawiska i jego społeczny charakter. Elementy literackie i funkcjonowanie formy w fandomie. Motywacje autorów do tworzenia tekstów. Fanfik jako utwór współtworzony, oparty na zbiorowej wyobraźni.
Sztambuch Sebalda Sauermanna — przyczynek do kultury intelektualnej patrycjatu wrocławskiego w drugiej połowie XVI i na początku XVII wieku
Authors: Szczepaniec Adam
Published: June 2023

Zarys biografii Sebalda IV Sauermanna. Podróż edukacyjna po Europie w latach 1578–1586. Krąg znajomych i przyjaciół w świetle sztambucha. Dekoracja malarska sztambucha. Księgozbiór Sebalda IV Sauermanna.
Czasopisma literackie i artystyczne uchodźctwa ukraińskiego w drugiej połowie lat czterdziestych XX wieku — aspekt ideologiczny
Authors: Holovata Larysa
Published: June 2023

Czasopisma wydawane przez Ukraiński Ruch Artystyczny oraz inne czasopisma „niezależne” (między innymi „Zahrava” i „Orlyk”). Czasopisma religijne (między innymi „Zhyttia i slovo”). Czasopisma o orientacji nacjonalistycznej (między innymi „Literaturno-naukovyi visnyk”).
Czerwone katechizmy. Socjalistyczne broszury agitacyjne w Królestwie Polskim na przełomie XIX i XX wieku
Authors: Piskała Kamil
Published: June 2023

Rozpowszechnienie broszur w społeczeństwie. Ich odbiór wśród czytelników. Forma piśmiennicza i treść. Znaczenie broszur w propagowaniu ideologii socjalistycznej. Zabiegi ułatwiające rozumienie tekstu przez czytelników.
Diagnozowanie potrzeb użytkowników bibliotek publicznych — koncepcja, metoda, pierwsze wnioski
Authors: Aleksandrowicz Renata , Bernacki Paweł
Published: June 2023

Badania użytkowników bibliotek w Polsce — wybrane przykłady. Diagnozowanie potrzeb użytkowników bibliotek publicznych — koncepcja i metody. Badanie testowe w praktyce.
Leishmaniose Visceral em Doente Imunocompetente: Relato de um Caso
Authors: Rodrigues Monteiro Miguel , Serra João Tiago , Gomes Filipa , Tinoco Joaquim
Published: June 2023

A leishmaniose é uma doença parasitária transmitida através da picada de flebotomíneos fêmea e que ocorre em regiões de clima tropical e subtropical. A leishmaniose visceral é a forma mais grave da doença, com uma mortalidade de 95% aos dois anos de infeção, quando não tratada. A leishmaniose visceral associa-se frequentemente a estados de imunossupressão, sendo a coinfeção com o vírus da imunodeficiência humana o mais prevalente. A maioria dos casos de leishmaniose visceral é causada pelas espécies Leishmania donovani e Leishmania infantum, sendo esta última a espécie endémica na bacia do Mediterrâneo. Em Portugal, o número de casos reportados de leishmaniose visceral tem vindo a diminuir nos últimos anos, sendo que entre 2017 e 2021 foram reportados 15 casos. Os autores apresentam um caso de leishmaniose visceral numa doente imunocompetente, que manifestou a pêntade clássica: febre, perda ponderal, hepatoesplenomegalia, pancitopenia e hipergamaglobulinemia. O diagnóstico foi feito pela observação de amastigotas da espécie Leishmania infantum no exame anatomopatológico da medula óssea e a doente foi tratada com sucesso com anfotericina B lipossómica.
Моделирование социально-психологических процессов формирования позиции населения относительно вакцинопрофилактики в условиях информационной пропаганды
Authors: Колесин Игорь Дмитриевич , Kolesin Igor Dmitrievich , Житкова Екатерина Михайловна , Zhitkova Ekaterina Mikhailovna
Published: June 2023

Статья посвящена разработке и анализу модели формирования позиции населения относительно противогриппозной вакцинопрофилактики в условиях ежегодно повторяющихся сезонных подъемах заболеваемости гриппом. Принятие того или иного решения в преддверии очередной прививочной кампании ставится в соответствие с психологической реакцией на результат прошлогоднего решения. Случай заболевания рассматривается как результат неудачно принятого решения, а его изменение связывается c характером психологической реакции на неудачу: эмоциональным либо сдержанным. Этот подход дополняется учетом влияния прививочной и антипрививочной пропаганды. Получено аналитическое выражение для соотношения стационарных долей согласных и несогласных на вакцинацию, что позволяет определять те значения параметров, которые обеспечивают нужное соотношение.
Метод прямого численного моделирования турбулентности с учетом истории процесса
Authors: Янилкин Юрий Васильевич , Yanilkin Yurii Vasil'evich , Гужова Асия Ринатовна , Guzhova Asiya Rinatovna , Дегтяренко Людмила Ивановна , Degtyarenko Lyudmila Ivanovna , Колобянин Вадим Юрьевич , Kolobyanin Vadim Yur'evich , Шмелев В А , Shmelev V A
Published: June 2023

Предлагается новый подход к прямому численному моделированию турбулентного перемешивания разноплотных смешивающихся и несмешивающихся веществ. Идея подхода заключается в том, чтобы в смешанных ячейках, содержащих перемешивающиеся вещества, разделить состояния гомогенных смесей от гетерогенных, состоящих из фрагментов с контактными границами. В работе описывается 2D метод, разработанный в методике ЭГАК (эйлерова газодинамика с концентрациями) для реализации описанного выше подхода. Метод тестируется на классической задаче турбулентного перемешивания, возникающего вследствие неустойчивости Рэлея-Тейлора при постоянном ускорении контактной границы между двумя разноплотными газами.
О точности разностных схем при расчете центрированных волн разрежения
Authors: Ковыркина Оляна Александровна , Kovyrkina Olyana Aleksandrovna , Остапенко Владимир Викторович , Ostapenko Vladimir Viktorovich
Published: June 2023

Проведен сравнительный анализ точности разностных схем UpWind (первого порядка), TVD (второго порядка) и WENO5 (третьего порядка по времени) при расчете для нелинейного уравнения переноса задачи Коши с кусочно-линейными разрывными периодическими начальными данными. Показано, что в случае устойчивых начальных разрывов, из которых формируется последовательность ударных волн, порядок сходимости всех трех схем между ударными волнами совпадает с их формальной точностью. В случае неустойчивых начальных разрывов, при распаде которых формируется последовательность центрированных волн разрежения, все три схемы имеют первый порядок сходимости внутри этих волн. Получена явная формула для дисбалансов разностных решений в центрированной волне разрежения. В случае схем повышенной точности эта формула хорошо согласуется с численными расчетами, не зависит от типа схемы и определяется погрешностью аппроксимации начальных данных в окрестности неустойчивого сильного разрыва.
Моделирование динамики двухфазной смеси газа и твердых дисперсных частиц
Authors: Немцев Максим Юрьевич , Nemtsev Maksim Yur'evich
Published: June 2023

Рассматривается математическая модель и численный метод для решения задач течения двухфазных смесей газа и мелких твердых частиц. Частицы предполагаются абсолютно жесткими, несжимаемыми и недеформируемыми. В качестве исходной модели берется широко используемая в литературе континуальная модель Р.И. Нигматулина, которая обладает двумя недостатками, а именно: не является строго гиперболической (т.е. вырождается в эллиптическую при определенных режимах течения) и имеет неконсервативный вид, что затрудняет ее численное решение. В работе предлагается метод регуляризации модели Р.И. Нигматулина на дискретном уровне, который позволяет устранить указанные недостатки и разработать численную модель, хорошо обусловленную для эволюционных задач течения газодисперсных смесей с недеформируемыми твердыми частицами. Метод регуляризации основывается на расщеплении исходной системы на две подсистемы, каждая из которых является строго гиперболической и имеет консервативный вид. Разработаны разностные схемы годуновского типа для численного решения этих подсистем. Тестирование предложенной модели и реализованных методов включает проверку сохранения однородного решения, образования ударных волн и волн разрежения в газе, волн компактирования и раскомпактирования в фазе частиц. Представлены также результаты численного моделирования взаимодействия ударной волны в газе с пристеночным слоем частиц.
Geochronology and Geochemistry of Mesoproterozoic Mafic Rocks in the Kontum Complex and Its Implication for the Columbia Reconstruction
Authors: Xu Chang , Gan Chengshi , Hieu Pham T. , Qian Xin , Minh Pham , Zhang Feifei , Wang Yuejun
Published: June 2023

The assembly–breakup of the Columbia/Nuna supercontinent is one of the most important issues in the Precambrian geology. The reconstruction of the Indochina Block in the Columbia supercontinent is poorly constrained by far, due to the deficiency of available geochronological and geochemical data for the exposed Precambrian rocks. The Mesoproterozoic plagioclase amphibolites in the Kontum Complex have significant implication for the reconstruction of the Indochina Block within the Columbia supercontinent. This study presents detailed petrological, zircon U–Pb geochronological and Lu–Hf isotopic, and whole-rock geochemical analyses for the plagioclase amphibolites. The plagioclase amphibolite protoliths were formed at ~1432–1403 Ma and experienced metamorphism at 486–457 Ma, suggesting the preservation of a Mesoproterozoic basement in the Kontum Complex. The samples are strongly enriched in LREEs and LILEs but depleted in Nb, Ta, and Ti. They have relatively low (87Sr/86Sr)i ratios (from 0.705055 to 0.708728), positive εNd (t) values (from +2.6 to +2.8), and positive zircon εHf (t) values (from +9.9 to +17.1). Such signatures suggest that they were derived from a mantle wedge that has been metasomatized by sediment-derived melts in an arc setting and caused the breakup of the Columbia supercontinent. The Kontum Complex from the Indochina Block, along with Laurentia and East Antarctica, was distributed at the Columbian periphery.
Estudio comparativo de métodos basados en reconocimiento de patrones para identificar movimientos de mano y muñeca por medio de señales SEMG
Authors: Guerrero Méndez Cristian David , Moreno Arévalo Brayan Sneider , Ruiz Olaya Andrés Felipe
Published: June 2023

Uno de los canales en la interacción hombre-máquina es el uso de señales de electromiografía de superficie (SEMG), las cuales, a través de técnicas de procesamiento y clasificación de características pueden proporcionar comandos para controlar dispositivos de asistencia, proporcionar accesibilidad y rehabilitación en personas en situación de discapacidad. Por ello, las metodologías de procesamiento de las señales deben enfocarse en el uso de métodos avanzados que permitan una adecuada identificación de la intención de movimiento de los usuarios. En el presente artículo, se realiza un estudio comparativo de algoritmos de reconocimiento de patrones desarrollados en Matlab para movimientos de miembro superior, relacionados con movimientos de mano y muñeca en personas diestras. Para esto, se utilizó la base de datos pública NinaPro, que proporciona registros de SEMG, mientras un usuario ejecuta diversos movimientos. En total se evaluaron 10 sujetos, 5 hombres y 5 mujeres. El algoritmo desarrollado incluye etapas de preprocesamiento, extracción de características y clasificación de patrones. La etapa de extracción de características incluyó el cálculo de raíz media cuadrática (RMS) de la señal. Se implementaron cuatro métodos de clasificación (KNN, NB, LDA y SVM), los cuales realizan una identificación de ocho movimientos isométricos e isotónicos de mano y muñeca. Como métrica de evaluación se utilizó el porcentaje de clasificación. Además, se realiza un análisis de significancia estadística para determinar diferencias entre clasificadores y grupos poblacionales. Como resultados, se determina que el mejor clasificador implementado es el SVM con un porcentaje de clasificación superior al 90 %, encontrando diferencias significativas entre los resultados de los métodos. No obstante, se observa que los hombres presentan mejores resultados que las mujeres, de acuerdo con la métrica de evaluación.
All in this together: lessons from international guideline developers on collaboration to reduce duplication and enable success in living guidelines
Authors: Cheyne Saskia , Norris Sarah , McFarlane Emma , Morgan Rebecca , Chakraborty Samantha , Carville Serena , Rohde Jeanett Friis , Sharp Steve , Hazlewood Glen Stewart , Askie Lisa M , Molag Marja , White Heath , Hill Kelvin , Whittle Samuel , Glen Fiona , Karpusheff Justine , Turner Tari
Published: June 2023

Objective
To describe experiences of collaborations in producing living guidelines by the Australian Living Evidence Consortium (ALEC), the World Health Organization (WHO), the National Institute for Health and Care Excellence (NICE), the Danish Health Authority (DHA), the Knowledge Institute of the Dutch Association of Medical Specialists, and the Canadian Rheumatology Association (CRA).
Methods
We developed a survey to collect the experiences of the collaborations in living guidelines. We collated the results and conducted a quantitative analysis for closed-ended survey questions. For open-ended questions we conducted a content analysis from the survey content.
Results
We included a convenience sample of twelve participants, from six living guideline collaborations across seven organisations. The consolidated results of the quantitative and content analyses were organized in the following themes: 1) facilitators of successful living collaboration, 2) barriers to successful living collaboration, 3) living influence on collaboration, 4) deciding to collaborate, 5) establishing mechanisms of collaboration, 6) communication and coordination of the collaboration, 7) sharing information, 8) publication, authorship, and recognition, and 9) evaluation.
Conclusion
The living guidelines collaborations were developed informally and are still ongoing. They resulted in successful coordination of key parts of the guideline process, including sharing of searches for evidence, data extractions and evidence summaries. Future living guidelines collaborations could benefit from early initiation and discussion of data sharing requirements, agreement of shared goals and questions, and regular evaluations.
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene
Authors: Sun Qi , Liu Diming , Cui Weiwei , Cheng Huimin , Zhang Ruihao , Gu Junlian , Liu Shuo , Huang Lixia , Zhuang Xiao , Lu Yi , Chu Bo , Li jian
Published: June 2023

Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood. In this work, we show that modulating cholesterol levels changes vulnerability of cells to ferroptosis. Cholesterol alters metabolic flux of the mevalonate pathway by promoting Squalene Epoxidase (SQLE) degradation, a rate limiting step in cholesterol biosynthesis, thereby increasing both CoQ10 and squalene levels. Importantly, whereas inactivation of Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), the branch point of cholesterol biosynthesis pathway, exhibits minimal effect on ferroptosis, simultaneous inhibition of both CoQ10 and squalene biosynthesis completely abrogates the effect of cholesterol. Mouse models of ischemia-reperfusion and doxorubicin induced hepatoxicity confirms the protective role of cholesterol in ferroptosis. Our study elucidates a potential role of ferroptosis in diseases related to dysregulation of cholesterol metabolism and suggests a new possible therapeutic target that involve ferroptotic cell death.
WITHDRAWN: Implementation of Reliability Centered Maintenance (RCM) in the background of industry 4.0 –Issues, Challenges, and Opportunities
Authors: Ur Rahman Khalil , Mian Zhibao , Yasir Ali
Published: June 2023

Reliability Centered Maintenance (RCM) is a well-known maintenance method originated in the aviation sector. It has shown a huge success such that consequently this technique has been adapted in more industrial sectors. Currently, the system maintenance has become more extensive and complex task. As a result, the equipment structures and functions are continuously becoming more complicated and diverse, which ultimately makes determining their reliability much more challenging. In addition, traditional RCM techniques can no longer meet the new requirements, including real-time condition monitoring, health diagnosis, remote maintenance, and intelligent maintenance required in industry 4.0. This paper highlights the challenges, issues and difficulties in adopting RCM with industry 4.0. A conceptual model-based solution is put forward to provide solutions towards the identified challenges. The model-based solution includes effective and promising solutions by combining RCM technology with artificial intelligence, digital twins, internet of things, big data, and model-based reliability analysis technology to provide advanced real-time data based equipment management, including online health monitoring and intelligence fault diagnostics and remote maintenance. This study will provide a base for implementing RCM with Industry 4.0 to provide smart and intelligent maintenance of the equipment’s or assets.
Description of trajectories of an evolution operator generated by mosquito population
Authors: Boxonov Zafar
Published: June 2023

In this paper, we study discrete-time dynamical systems generated by evolution operator of mosquito population. An invariant set is found and a Lyapunov function with respect to the operator is constructed in this set. Using the Lyapunov function, the global attraction of a fixed point is proved. Moreover, we give some biological interpretations of our results.
Impact of glass granular replacement as a coarse aggregate on the compressive strength of a concrete mixture; Normalaization and Modeling
Authors: Ahmad Soran Abdrahman , Ahmed Dler Ali , Rostam Khalan Jalil , Fqi Kawa Omar
Published: June 2023

In most countries in the third world, waste material management become one of the important objects, since its quantity increase day by day. One of the main components of waste materials is waste glass; since has large usage in different functions in human’s daily life. Many researchers have studied the usage of waste glass as cement replacement or sand replacement in concrete. This article deals with the usage of waste glass granular as coarse aggregate in concrete since coarse aggregate provides the larger composition of the concrete component for that purpose review has been done of the previous work to show the effect of the used waste glass granular as replacement of coarse aggregate on the fresh and mechanical properties of concrete at the same time the experimental data have been collected from previous work and statistical models have been proposed using artificial neural network (ANN), with multi-linear regression (MLR) to predict the compressive strength of concrete. Different statistical parameters have been used to assess and compare the efficiency of ANN to MLR and select the most efficient model. ANN consider as most sufficient since its R2 value is 26.5% higher than MLR with SI value 54% lower than MLR model.
EFFICACY OF POLYACRYLAMIDE HYDROGEL FOR FEMALE URINARY INCONTINENCE: OUTCOME OF A SINGLE CENTRE
Authors: Buckingham Mickey , Sultana Mahbuba , Thomas James M , Andrews Vasanth
Published: June 2023

Introduction: Periurethral injection with polyacrylamide hydrogel (PAHG, Bulkamid®) is a minimally invasive treatment option to be considered for women with stress urinary incontinence. The manufacturer recommends injecting between 1.5 ml and 2 ml periurethrally. This study aims to evaluate the long-term efficacy of PAHG, and to determine whether there is a correlation between the volume of PAHG injected and the outcome in terms of symptoms.
Methods: A retrospective study was conducted between 2011 and 2018. Patients were contacted by telephone and the International Consultation on Incontinence Questionnaire – Urinary Incontinence Short Form (ICIQ-UI SF) was used to assess their symptoms. A linear regression analysis test was performed to assess the correlation between the outcome and the volume of PAHG injected.
Results: One hundred and fifteen PAHG injections were performed on 101 patients. The volume of PAHG injected ranged from 0.8 ml to 3 ml. Two patients reported procedure-related complications. Of the patients that attended their three-month follow-up, 62 (58.5%) patient-episodes reported an improvement. 62 patients were contacted by telephone and the median length of follow-up was 37.5 months. An improvement in the ICIQ-UI SF score was observed in 45.8% of patients with a mean improvement of 4 points. The volume of PAHG injected did not affect the outcome. 31% also reported a benefit with PAHG five years after their injection following previous incontinence surgery.
Conclusions: PAHG injection is safe and improves symptoms of urinary incontinence at up to 7.5 years in 45.8% of women. PAHG is also useful after previous incontinence surgery. The volume of PAHG injected did not influence the outcome.
IMPROVEMENT OF THE MEDICAL CARE QUALITY MANAGEMENT MODEL BASED ON THE INTERNAL AUDIT MECHANISM IN THE HEALTHCARE FACILITY
Authors: Loboda Andrii , Demikhova Nadiia , Olha Smiianova Olha Smiianova , Yasenok Viktoriia
Published: June 2023

Introduction. Internal audit aims to improve the processes and outcomes of medical services by systematically reviewing the components of medical care in terms of certain criteria and implementing changes where the service does not reach the expected level. Severization of requirements for HCF service quality and increasing competition in HCFs require the elaboration and implementation of dynamic continuous internal mechanisms, which will contribute to healthcare quality improvement, professional development of medical personnel, and the increased satisfaction of medical service consumers.
Objective: Elaboration of a medical and social internal audit mechanism in order to improve medical care quality at the level of a healthcare facility.
Materials and Methods. We used system analysis, meta-analysis, descriptive modeling, medical and sociological survey, statistical analysis, and logical generalization in the study. Data collection methods were: a survey and copying of data from the primary accounting and reporting documents.
Results. The study involved 226 patients with chronic noncommunicable diseases who were followed up at Sumy HCFs. The correspondence between the actual data in the outpatient medical records with the protocol’s quality indicators was assessed. Internal audit of the subjects’ satisfaction with medical services showed that they were sufficiently aware of the disease course, complication prevention, and the risks of non-compliance – 97% of patients confirmed that they received detailed information from their physician; however, they did not comply with the doctor's recommendations or complied poorly.
Conclusions. We registered subjects’ poor compliance and unsatisfactory attitude towards the follow-up procedure. The development and implementation of the medical and social mechanism of internal audit contributed to the practical adoption of a management decision to ensure the continuous improvement of medical care quality for patients with chronic noncommunicable diseases, namely additional behavioral approaches to increase the level of patients’ compliance with the doctor's recommendations and their active involvement in follow-up control.
Stock Liquidity and Cash Holdings: Evidence from Malaysia
Authors: Shiang Shen Kwan  , Roy W. L. Khong  , Woan Ting Hung
Published: June 2023

The level of cash held by listed companies has raised academic interest. In particular, many studies have been conducted to understand the reason why companies hold so much cash. Previous studies on the determinants of cash holdings have focused on firm-specific characteristics. More recently, researchers have found that stock liquidity played an important role in explaining the cash holding behaviour. This study examines the effect of stock liquidity on cash holdings among listed companies in Malaysia. The findings indicate that stock liquidity has a positive impact on cash holdings. This suggests that companies have a higher propensity to hold cash to repurchase its own stocks, which resulted in higher stock liquidity.
The Hedging Ability of Gold, Silver and Bitcoin against Inflation in ASEAN Countries
Authors: Shaista Arshad  , Thi Hong Nhung Vu  , Too Shaw Warn  , Loke Mei Ying
Published: June 2023

This paper examines the hedging ability of gold, silver, and Bitcoin against inflation in ASEAN countries. The inclusion of Bitcoin as a hedge is relatively new in literature and the effect of hedging has been exacerbated post Global Financial Crisis, when the prices of precious metals have increased continuously. To serve that objective, the student-t EGARCH (1,1) model is first used to study the relationship between average asset return and inflation and next a quantile regression model is applied to explore the relationship between different quantiles of asset return and inflation. This ensures the hedging potential of each asset to be equally strong in bearish and bullish conditions. The tests show that the results from student-t EGARCH (1,1) model and quantile regression model are different while the results pre and post GFC are similar in most of the cases. The quantile regression model, which accounts for different quantiles for asset returns, indicates that gold, silver, and Bitcoin appear to be a hedge and safe haven in ASEAN countries. However, from the student-t EGARCH (1,1) model, which accounts for average asset returns, Bitcoin is a hedge asset but none of the three assets serves as a safe haven in ASEAN countries.
Evaporation as a Method for Obtaining Plant Concentrates
Authors: Kulikova Nataliya , Chernobrovina Antonina , Roeva Natalia , Popova Olga
Published: June 2023

Low-pressure vacuum evaporation is an effective way to obtain dry concentrates. However, some factors may affect its efficiency and speed. This article introduces the effect of technological factors on the evaporation process in a rotary evaporator. The research objective was to select the optimal mode to obtain concentrates and extracts from plant materials.

The experimental studies involved standard research methods and a BUCHI Rotavapor laboratory rotary evaporator (BUCHI, Switzerland). The research featured a water-alcohol extract of wild blueberries and an enzymatic hydrolysate of grain sorghum (durra), obtained by biotechnological treatment with amylolytic enzyme preparations.

The optimal evaporation mode included the following values: the volume of the evaporation flask was 1 L; the wall thickness of the flask was 1.8 mm; the angle of inclination was 25°; the rotation speed was 280 rpm; the temperature heating bath was 50–60°C; the steam temperature in the evaporator was 30–40°C. For condensation, the temperature of the refrigerant in the condenser was 10–20°C. The experiment yielded a concentrate of blue-violet blueberries with 70–72% solids. The content of polyphenolic compounds was 1.86 times as high as in the original water-alcohol extract while that of anthocyanins was 1.4 times as high. The enzymatic hydrolysate of grain sorghum yielded a condensed sugar syrup with 78–80% solids and 91–92% reducing sugars in terms of glucose equivalent.

The research provided optimal modes of evaporation for extracts and enzymatic hydrolysates from plant raw materials in a rotary evaporator. The plant concentrates had a high content of solids and maintained the sensory properties of the raw material.
Effects of a Plant-Based Additive on the Properties of Flour and Dough during Fermentation
Authors: Maslov Alexander , Mingaleeva Zamira , Yamashev Timur , Starovoitova Oksana
Published: June 2023

To ensure a balanced diet, bakers use plant-based raw materials with a high nutritional value which affect the properties of flour and dough. We aimed to study the effects of a complex additive based on plant components on wheat flour’s amylolytic activity and gas-forming ability, as well as on the dough’s rise and gas-retaining ability during fermentation.

Our study objects included premium wheat flour, a water-flour suspension, and wheat dough with a complex additive (at concentrations of 10, 16, and 22% by weight of flour mixtures). The additive contained whole wheat flour, crushed sprouted spelt, powdered pumpkin seeds, oyster mushrooms, and gooseberries at a ratio of 56.3:25.0:17.2:0.9:0.6, respectively. An amylograph-E was used to study the viscosity of the water-flour suspension during heating, an ICHP-1-2 apparatus measured the falling number, and an F4 rheofermentometer assessed the flour’s gas-forming ability and the dough’s rise and gas-retaining ability.

The complex additive improved the enzymatic activity of the flour, increased the dough rise by an average of 8.4 mm, and reduced the fermentation time needed to reach the maximum height by an average of 17.8%, compared to the control. The total volume of carbon dioxide, as well as the volumes of lost and retained carbon dioxide, increased by an average of 35.8, 99.7, and 26.9%, respectively, compared to the control. The optimal concentration of the complex additive introduced into premium wheat flour was 16%, at which the dough rose to its maximum height and had the longest porosity time. To obtain high-quality products with this concentration of the additive, the total time of dough fermentation and proofing should be reduced by 17.8% compared to the unfortified dough.

The results can be used in the production of bakery products from premium wheat flour fortified with the complex additive based on plant components. During the process, it is important to determine the duration of dough maturation and reduce the total time of dough fermentation and proofing depending on the concentration of the additive. Further research is needed to study the effect of the complex additive on the structural and mechanical properties of dough during its development.
Ultrasound Treatment of Iota-Carrageenan and Guar Gum
Authors: Nitsievskaya Kseniya , Stankevich Svetlana , Boroday Elena
Published: June 2023

Hydrocolloids make it possible to produce low-calorie analogues of traditional foods that maintain the original structural properties. Electrophysical methods control viscosity and stabilize food systems. However, the stabilizing effect of ultrasonic treatment on gel remains understudied. The research featured the effect of ultrasonic treatment on hydrocolloids (polysaccharides) used in meat or fish jelly, marmalades, marshmallows, puddings, ice cream, etc.

The study involved samples of colloidal systems based on iota-carrageenan or guar gum and purified water (1:100). The samples underwent ultrasonic treatment at various time and pH ranges. The viscosity, active acidity, temperature, and transparency (transmission coefficient, T, %) of the obtained colloidal systems were determined using standard methods, while the sensory profile was defined by the descriptor-profile method.

Hydrocolloids were subjected to ultrasound at pH 3.9, 7.0, and 9.0. The colloidal viscosity of the iota-carrageenan sample was 47.6 mPa·s at neutral pH, 45.7 mPa·s at acidic pH, and 22.3 mPa·s at alkaline pH. The viscosity of the hydrocolloid system with guar gum depended on the pH of the medium: it decreased during processing from 119.0 to 64.8 mPa·s in the neutral medium but remained the same (3.5 ± 0.2 mPa·s) in the acid medium and reached 6.52 mPa·s in the alkaline medium. The maximum temperature of the colloidal system was 46.5°C in a neutral medium.

The system with iota-carrageenan showed the best result at medium acidity in the range of 3.9–6.0 units and produced a fluid gel-like structure. Sonicated iota-carrageenan could be recommended as a gelling agent. Guar gum viscosity, on the contrary, lost its viscosity and failed to produce the desired structure.
Green algae outcompete cyanobacteria in a shallow lake, Longhu Lake
Authors: Li Jingjing , Xiao Xinyan , Xian Xuanxuan , Li Shuai , Yu Xin , Zhang Xian
Published: June 2023

Green algae are natural competitors of cyanobacteria, but we still do not know why green algae have a competitive advantage in shallow lakes. In this study, we used qPCR to quantify and monitor green algae and cyanobacteria in Longhu Lake. Our results showed that green algae were dominant in Longhu Lake, accounting for 71.80–80.31%. The temporal and spatial dynamics of green algal blooms were consistent with that of total organic nitrogen (TON), indicating that organic nitrogen may be the key trigger of green algal blooms. Nitrogen and phosphorus were excessive, and the peak of ammonia nitrogen occurred during the blooms, implying that ammonia nitrogen may be one of the important factors stimulating green algal blooms. Spearman correlation analysis and RDA analysis showed that green algae and cyanobacteria were positively correlated with water temperature, TON, and ammonia nitrogen, indicating that they have similar favorable growth conditions in Longhu Lake. Our results indicated that the combined effects of elevated water temperature, excessive nitrogen and phosphorus, non-stratification, and short water retention time could favor the competitive dominance of green algae in Longhu Lake. The findings here improve our understanding of the competition between green algae and cyanobacteria in shallow lakes.
К вопросу использования технологии Moodlе в организации учебного процесса в вузе.
Authors: Smirnova Marina Aleksandrovna , Fedorov Oleg Anatolevich
Published: June 2023

The ways of modernization of education through digital technologies are discussed. An example of using MOODL technology is given.
Planeación y gestión de los consejos comunitarios de la región del Patía del sur occidente colombiano
Authors: Toro Chalá Elizabeth , Macuacé Otero Ronald Alejandro , Sevillano Rodríguez María Eugenia
Published: June 2023

El presente artículo devela los procesos de planeación y gestión de los consejos comunitarios de la región del Patía en el departamento del Cauca, ubicado en el sur occidente colombiano. La investigación se sitúa bajo un enfoque epistemológico histórico hermenéutico, desde el que se implementaron técnicas de análisis documental y entrevistas grupales con el propósito de comprender situaciones o logros particulares de la gestión comunitaria desde los relatos, experiencias y vivencias de los consejos comunitarios. Para facilitar la complementariedad de los datos, se triangularon tres técnicas investigativas: la observación registrada en los diarios de campo, las entrevistas y las técnicas de investigación documental. Los resultados relacionan al Estado colombiano como orientador de lineamientos para fortalecer la identidad cultural, el territorio colectivo, el desarrollo económico y social que garanticen los derechos y la igualdad de oportunidades mediante los planes de etnodesarrollo; mientras que los consejos comunitarios bajo su cosmovisión, se apropian el plan de vida para la sostenibilidad, se identifican como garantes de la protección y la defensa del territorio, a través su organización comunitaria preservan prácticas agroecológicas propias, las cuales contribuyen a mantener y rescatar saberes ancestrales afines a los objetivos de desarrollo sostenible.
Synthesis, Structure, and Properties of Dihydrotetrathiafulvalenes
Authors: Aitken R. Alan , Fotherby Fiona M.
Published: June 2023

Although less well known than their fully unsaturated analogues, dihydrotetrathiafulvalenes
(dihydro-TTFs) has been of considerable recent interest as components of organic conducting
materials. In this article, the various methods for their synthesis are reviewed and this is followed
by a survey of their structure and properties, including those of charge transfer salts, and an
account of their reactions.
Study of Active Phytochemicals and Mechanisms of Cnidii Fructus in
Treating Osteoporosis Based on HPLC-Q-TOF-MS/MS and Network
Pharmacology
Authors: Xu Yincong , Zhang Shuai , Yuan Shinong , Su Yanlei , Jia Yuqian , Zhang Yajing , Duan Xuhong
Published: June 2023

Introduction:

This study aimed to clarify the anti-osteoporosis mechanism of Cnidii
Fructus (CF) via network pharmacology and experimental verification.

Methods:

HPLC fingerprints combined with HPLC-Q-TOF-MS/MS analysis confirmed common
components (CCS) of CF. Then, network pharmacology was used to investigate the anti-OP mechanism
of CF, including potential anti-OP phytochemicals, potential targets, and related signalling
pathway. Molecular docking analysis was carried on investigating the protein-ligand interactions.
Finally, in vitro experiments were performed to verify anti-OP mechanism of CF.

Results:

In this study, 17 compounds from CF were identified by HPLC-Q-TOF-MS/MS and
HPLC fingerprints and then were further screened key compounds and potential targets by PPI
analysis, ingredient-target network and hub network. The key compounds were SCZ10 (Diosmin),
SCZ16 (Pabulenol), SCZ6 (Osthenol), SCZ8 (Bergaptol) and SCZ4 (Xanthotoxol). The potential
targets were SRC, MAPK1, PIK3CA, AKT1 and HSP90AA1. Molecular docking further analysis
indicated that the five key compounds have a good binding affinity with related proteins. CCK8
assays, TRAP staining experiments, and ALP activity assays concluded that osthenol and bergaptol
inhibited osteoclast formation and promoted osteoblast bone formation to improve osteoporosis.

Conclusion:

Based on network pharmacology and in vitro experiments analysis, this study
revealed that CF possessed an anti-OP effect, and its potential therapeutic effect may be involved
with osthenol and bergaptol from CF.
Identification of Tyrosinase Inhibitory Peptides from Sea Cucumber (Apostichopus
japonicus) Collagen by in silico Methods and Study of their Molecular
Mechanism
Authors: Chen Hui , Yao Yourong , Xie Tingyu , Guo Honghui , Chen Sijin , Zhang Yiping , Hong Zhuan
Published: June 2023

Aims:

Identify novel tyrosinase inhibitory peptides from sea cucumber (Apostichopus
japonicus) collagen using in silico methods and elucidate the molecular interaction mechanism.

Background:

Tyrosinase is a key enzyme in the melanin biosynthesis pathway, to restrain melanin
production and reduce the appearance of associated skin diseases, inhibition of tyrosinase activity
is one of the most effective methods.

Objective:

The collagen from Apostichopus japonicus, which consists of 3,700 amino acid residues,
was obtained from the National Center for Biotechnology Information (NCBI) as the accession
number of PIK45888.

Method:

Virtual hydrolyzed method was used, and the peptides generated were compared to the
previously established BIOPEP-UWM database. In addition, peptides were examined for their solubility,
toxicity, and tyrosinase-binding capacity.

Result:

A tripeptide CME with optimal potential inhibitory activity against tyrosinase was identified,
and its inhibitory activity was validated by in vitro experiments. The IC50 value of CME was
0.348 ± 0.02 mM for monophenolase, which was inferior to the positive control peptide glutathione,
while it had an IC50 value of 1.436 ± 0.07 mM for diphenolase, which was significantly
better than glutathione, and the inhibition effect of CME on tyrosinase was competitive and reversible.

Conclusion:

In silico methods were efficient and useful in the identification of new peptides.
Pharmacological Profile of Novel Anti-cancer Drugs Approved by
USFDA in 2022: A Review
Authors: Sangwan Kavita , Sharma Vipasha , Goyal Parveen Kumar
Published: June 2023

Background:

For any drug molecule, it is mandatory to pass the drug
approval process of the concerned regulatory authority, before being marketed. The
Food and Drug Administration (FDA), throughout the year, approves several new drugs
for safety and efficacy. In addition to new drug approvals, FDA also works on improving
access to generic drugs, aimed to lower the cost of drugs for patients and improve
access to treatments. In the year 2022 twelve new drug therapies were approved for
managing varying cancers.

Methods:

This manuscript is focused to describe the pharmacological aspects including
therapeutic uses, mechanisms of actions, pharmacokinetics, adverse effects, doses,
indication for special cases, contraindications, etc., of novel FDA-approved anticancer
drug therapies in the year 2022.

Result:

FDA has approved about 29% (11 out of 37) novel drug therapies for varying
types of cancers such as lung cancer, breast cancer, prostate cancer, melanoma,
leukemia, etc. The Center for Drug Evaluation and Research CDER has reported that
90% of these anticancer drugs (e.g. Adagrasib, Futibatinib, Mirvetuximabsoravtansinegynx,
Mosunetuzumab-axb, Nivolumab and relatlimab-rmbw, Olutasidenib, Pacritinib,
Tebentafusp-tebn, Teclistamab-cqyv, and Tremelimumab-actl) as orphan drugs and
recommended to treat rare or uncommon cancers such as non-small cell lung cancer,
metastatic intrahepatic cholangio-carcinoma, epithelial ovarian cancer, follicular
lymphoma, metastatic melanoma, metastatic uveal melanoma, etc. CDER has identified
six anticancer drugs (e.g. Lutetium (177Lu)vipivotidetetraxetan, Mirvetuximabsoravtansine-
gynx, Mosunetuzumab-axb, Nivolumab and relatlimab-rmbw, Tebentafusp-tebn,
Teclistamab-cqyv) as first-in-class drugs i.e. drugs having different mechanisms of
action from the already existing ones. The newly approved anticancer drugs shall
provide more efficient treatment options for cancer patients. Three FDA-approved
anticancer drugs in the year 2023 are also briefly described in the manuscript.

Conclusion:

This manuscript, describing the pharmacological aspects of eleven
anticancer novel drug therapies approved by the FDA, shall serve as a helpful document
for cancer patients, concerned academicians, researchers, and clinicians, especially
oncologists.