bluuebunny/crossref_metadata_2025 huggingface dataset:
¿Los profesionales sanitarios están preparados para la eutanasia?
Authors:   Hospital Universitario Nuestra Señora de Candelaria (España), Meneses Ramírez Sergio , Hernández Xumet Juan Elicio ,   Universidad de La Laguna (España)
Published: March 2023

The entry into force on June 25, 2021 of the Organic Law 3/2021, of March 24, on the regulation of euthanasia (LORE) has meant the recognition of end-of-life care and respect for the dignity of people in situations of poor prognosis. The aim of this review is to evaluate the evidence on the knowledge of health professionals in relation to euthanasia. A systematic search was carried out in 10 databases (Dialnet, Cuiden, Scopus, Medline, CINAHL, Cochrane, Scielo, the official meta-search engine of the University of La Laguna, PubMed and the Virtual Health Library) in order to identify the studies carried out on this subject in the last 10 years. A notable paucity of scientific evidence on the knowledge of health professionals regarding euthanasia has been found. Likewise, there is a need to implement instructional programs that address it from the initial stages of training. More studies of this type are also needed.
Which Exercise Approaches Work for Relieving Cancer-Related Fatigue? A Network Meta-analysis
Authors: Dong Bei , Qi Yishu , Lin Lu , Liu Tingting , Wang Shaotong , Zhang Yueyue , Yuan Yang , Cheng Hui , Chen Qiuyun , Fang Qian , Xie Zhengyang , Tian Li
Published: March 2023

OBJECTIVE: To determine the most effective exercise modalities for managing cancer-related fatigue during and after cancer treatment.

DESIGN: Network meta-analysis (NMA) of randomized controlled trials.

LITERATURE SEARCH: Seven electronic databases were systematically searched from inception to January 2022.

STUDY SELECTION CRITERIA: Randomized controlled trials testing the effects of exercise on relieving cancer-related fatigue in adult patients with cancer.

DATA SYNTHESIS: An NMA of 56 studies was conducted, and the PRISMA-NMA guidelines were followed when reporting results. To determine the most effective interventions, the surface under the cumulative ranking curve (SUCRA) value was calculated for each exercise modality.

RESULTS: Combined aerobic and resistance exercise (standardized mean difference [SMD], 1.57; credible interval [CrI], 1.03–2.10), yoga (SMD, 1.02; CrI: 0.44, 1.60), and regular physical activity (SMD, 1.07; CrI: 0.21, 1.92) could significantly alleviate cancer-related fatigue compared to control groups (usual care, wait-list, and regular physical activity). Combined aerobic and resistance exercise (SUCRA, 97.2%) had the highest probability of efficacy, followed by yoga (SUCRA, 75.5%) and regular physical activity (SUCRA, 74.1%). During cancer treatment, combined aerobic and resistance exercise (SUCRA, 94.5%) ranked first in efficacy, followed by regular physical activity (SUCRA, 82.1%) and yoga (SUCRA, 73.8%). After cancer treatment, only combined aerobic and resistance exercise (SMD, 0.99; CrI: 0.13, 1.84) had a significant effect on cancer-related fatigue.

CONCLUSION: Combined aerobic and resistance exercise, yoga, and regular physical activity were the most effective exercise modalities for alleviating cancer-related fatigue. Combined aerobic and resistance exercise is recommended during and after cancer treatment. J Orthop Sports Phys Ther 2023;53(6):343–352. Epub: 23 March 2023. doi:10.2519/jospt.2023.11251
Catalysis at the Origin of Life
Authors: de Graaf Ruvan , De Decker Yannick , Sojo Victor , Hudson Reuben
Published: March 2023

The construction of hypothetical environments to produce organic molecules such as metabolic intermediates or amino acids is the subject of ongoing research into the emergence of life. Experiments specifically focused on an anabolic approach typically rely on a mineral catalyst to facilitate the supply of organics that may have produced prebiotic building blocks for life. Alternatively to a true catalytic system, a mineral could be sacrificially oxidized in the production of organics, necessitating the emergent ‘life’ to turn to virgin materials for each iteration of metabolic processes. The aim of this perspective is to view the current ‘metabolism-first’ literature through the lens of materials chemistry to evaluate the need for higher catalytic activity and materials analyses. While many elegant studies have detailed the production of chemical building blocks under geologically plausible and biologically relevant conditions, none appear to do so with sub-stoichiometric amounts of metals or minerals. Moving toward sub-stoichiometric metals with rigorous materials analyses could finally demonstrate the viability of an elusive cornerstone of the ‘metabolism-first’ hypotheses: catalysis. We emphasize that future work should aim to demonstrate decreased catalyst loading, increased productivity, and/or rigorous materials analyses for evidence of true catalysis.
MB-pol(2023): Sub-chemical accuracy for water simulations from the gas to the liquid phase
Authors: Zhu Xuanyu , Riera Marc , Bull-Vulpe Ethan F. , Paesani Francesco
Published: March 2023

We use the MB-pol theoretical/computational framework to introduce a new family of data- driven many-body potential energy functions (PEFs) for water, named MB-pol(2023). By employing larger 2-body and 3-body training sets, including an explicit machine-learned representation of 4-body energies, and adopting more sophisticated machine-learned representations of 2-body and 3-body energies, we demonstrate that the MB-pol(2023) PEFs achieve sub-chemical accuracy in modeling the energetics of the hexamer isomers, outperforming both the original MB-pol and q-AQUA PEFs, which currently provide the most accurate description of water clusters in the gas phase. Importantly, the MB-pol(2023) PEFs provide remarkable agreement with the experimental results for various properties of liquid water, improving upon the original MB-pol PEF and effectively closing the gap with experimental measurements.
Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme-Responsive "Covalent-Assembly" Fluorescent Probes with Tailor-Made Properties
Authors: RENAULT Kévin , CAPELLO Yoan , YAO Shun , HALILA Sami , ROMIEU Anthony
Published: March 2023

Latent cyclic carbon-centered nucleophiles (latent C-nucleophiles) are recently proving their value in the field of reaction-based fluorescent probes, far beyond their primary utility in organic synthesis. They are typically used to introduce a Michael acceptor moiety acting as a recognition/reaction site for analyte to be detected or as a kinetic promoter of fluorogenic cascade reactions triggered by a reactive species. C-nucleophiles bearing a further reactive handle offer an additional opportunity for tuning the physicochemical/targeting properties or providing drug-releasing capabilities to these probes, through the covalent attachment of ad hoc chemical moiety. In order to implement such strategy to fluorogenic/chromogenic enzyme substrates based on the "covalent-assembly" principle, we have explored the potential of some functionalized derivatives of barbituric acid, piperidine-2,4-dione and Meldrum's acid. Our investigations based on the rational design and analytical validations of enzyme-responsive caged precursors of fluorescent pyronin dyes and 7-(diethylamino)coumarin-3-carboxylic acid, led to identify a versatile candidate suitable for this late-stage structural optimization approach with a minor impact on stability and activation kinetics of probe. This Meldrum's acid derivative, synthesized from levulinic acid, enables to either enhance water solubility or achieve the reversible conjugation of a targeting ligand, while promoting in situ formation of fluorophore upon enzymatic activation. This study opens the way to novel multifunctional fluorescence imaging probes and optically modulated small conjugate-based theranostics drawing on the promising "covalent-assembly" strategy.
Polarizable Embedding with Periodic Boundary Conditions
Authors: Kvedaravičiūtė Sonata , Carrasco-Busturia David , Møller Klaus B. , Olsen Jógvan Magnus Haugaard
Published: March 2023

We introduce periodic boundary conditions (PBCs) for the induced electrostatics in the polarizable embedding (PE) model through the minimum-image convention (MIC). It is a simple yet effective approach that includes a more physically accurate description of the polarization throughout the molecular system. Using PE with MIC (PE-MIC), we shed new light on the limitations of commonly employed cutoff models, such as the droplet model, when used in PE calculations. Specifically, we investigate the effects of the unphysical polarization at the outer boundary by comparing induced dipoles and the associated electrostatic potentials, as well as some optical properties of solute–solvent and biomolecular systems. We show that the magnitude of the inaccuracies caused by the unphysical polarization depends on multiple parameters: the nature of the quantum subsystem and of the environment, the cutoff model and distance, and the calculated property.
N-heteroacenes as an organic gain medium for room temperature masers
Authors: Attwood Max , Xu Xiaotian , Newns Michael , Meng Zhu , Ingle Rebecca , Wu Hao , Chen Xi , Xu Weidong , Ng Wern , Abiola Temitope , Stavros Vasilos , Oxborrow Mark
Published: March 2023

The development of future quantum devices such as the maser, i.e., the microwave analog the laser, could be well-served by exploration of chemically tuneable organic materials. Current iterations of room temperature organic solid-state masers are composed of an inert host material that is doped with a spin-active molecule. In this work, we have systematically modulated the structure of three nitrogen-substituted tetracene derivatives to augment their photoexcited spin dynamics and then evaluated their potential as novel maser gain media. To facilitate these investigations, we adopted an organic glass former, 1,3,5-tri(1-naphthyl)benzene (1-TNB) to act a universal host. These chemical modifications impacted the rates of intersystem crossing, triplet spin polarisation, triplet decay and spin-lattice relaxation, leading to significant consequences on the conditions required to surpass the maser threshold.
High-Throughput Automated Exploration of Phase Growth Kinetics in Quasi-2D Formamidinium Metal Halide Perovskites
Authors: Yang Jonghee , Lawrie Benjamin J. , Kalinin Sergei V. , Ahmadi Mahshid
Published: March 2023

Quasi-two-dimensional (2D) metal halide perovskites (MHPs) are an emerging material platform for sustainable functional optoelectronics, however the uncontrollable, broad phase distribution remains a critical challenge for applications. This is because the basic principles for controlling multiple phases in quasi-2D MHPs remain poorly understood, due to the rapid crystallization kinetics during the conventional thin-film fabrication process. Herein, a high-throughput automated synthesis-characterization-analysis workflow is implemented to accelerate material exploration in formamidinium (FA)-based quasi-2D MHP compositional space, revealing the early-stage phase growth kinetics which fundamentally determines the phase distributions. We observe that the prominent n=2 2D phase restricts the growth kinetics of 3D-like phases – α-FAPbI3 MHPs where the spacers are coordinated to the surface. δ-FAPbI3 phase further inhibits the growth of 3D-like phases. It is found that thermal annealing is a critical step for proper phase growth, although it can lead to the emergence of unwanted local PbI2 crystallites. Additionally, fundamental insights into the precursor chemistry associated with spacer-solvent interaction that determines the morphologies and microstructures of quasi-2D MHP films are demonstrated. Our high-throughput study provides comprehensive insights into the fundamental principles in quasi-2D MHP phase control and enables new control of the functionalities of complex materials systems for sustainable device applications.
Chemical Oxygen Demand (COD) and Total Suspended Solid (TSS) Removal from Rubber Wastewater Factory Using Electrocoagulation Technique
Authors: Munandar Andika , Nabila Khairratul , Azizah Rifka Noor
Published: March 2023

Rubber industrial wastewater is obtained during washing, shredding, grinding, crumbbing, drying, and pressing bokar. The wastewater produced can be an environmental pollutant because it contains relatively large amounts of organic matter. One alternative to treating rubber wastewater is to use the electrocoagulation process, which is a combination of the coagulation and electrolysis processes. This electrocoagulation process has several advantages in the form of simple equipment, short time, produces odorless wastewater, does not require large areas of land, and can remove various contaminants in water. In this study, rubber wastewater was treated by electrocoagulation using a batch system with variations in the contact time used, namely 20, 40, 60, 80, and 100 minutes. This type of research is experimental research, and descriptive analysis is carried out. Rubber wastewater is physically gray-black before treatment and chemically contains large organic matter. The results of this study showed that the content of chemical oxygen demand (COD) and total suspended solids (TSS) before processing had values of 691 mg/L and 317 mg/L. Optimum conditions for the elimination of COD and TSS contents were achieved within 80 minutes with the percentage of elimination being 89% and 85%.
Trabajo remoto en casa: riesgos, efectos y retos en la docencia universitaria
Authors: Ordóñez-Hernández Cecilia Andrea , Leal-Márquez Diana , Villota Castillo Adriana Marcela
Published: March 2023

Si bien el teletrabajo se ha transformado con el tiempo, en el último año se ha experimentado un cambio significativo en lo que respecta a su relación con el desarrollo de la labor docente. Aunque la educación a distancia (mediada por tecnologías, virtual, en línea o asistida) ha existido desde el siglo XX, la gran mayoría de docentes, acostumbrados a brindar una enseñanza presencial, se han visto en la obligación de iniciar un proceso de aprendizaje hacia las nuevas tecnologías de información y comunicación (TIC) para impartir enseñanza virtual, debido principalmente a los impactos de la pandemia de la COVID-19, que recayó también sobre las metodologías de enseñanza-aprendizaje.
Tecnoestrés en el profesorado de una universidad colombiana
Authors: Vivas-Manrique Samuel David , Duarte Alarcón Carolina , Ochoa Muñoz Andrés Felipe
Published: March 2023

Las tecnologías de información y comunicación han favorecido los procesos de formación, con lo que se ha posibilitado el surgimiento de nuevos modelos educativos que combinan de una y otra forma el uso de la virtualidad en la enseñanza y el aprendizaje. Sin embargo, el uso de dispositivos tecnológicos también puede causar tecnoestrés y derivar en afectaciones a la salud, bienestar y desempeño de los profesores. Es fundamental, por tanto, identificar este peligro psicosocial emergente a fin de establecer medidas preventivas y correctivas que protejan al equipo docente y por ende favorezcan la calidad educativa.
Sürdürülebilir Turizmde Geleneksel El Sanatları Ürünlerinin Rolü ve Önemi: Hatay İlinde Bir Araştırma (The Role and Importance of Traditional Handicrafts in Sustainable Tourism: A Research in Hatay)
Authors: Belber Burcu Gülsevil , Duman Damla
Published: March 2023

Kaynağını Anadolu’nun binlerce yıllık köklü tarihinden alan geleneksel Türk el sanatları, günümüzde önemli bir kültürel miras unsuru olarak turizm kapsamında değerlendirilmektedir. Toplumların kültürel kişiliğinin yansıtıcı bir aracı olarak görülen geleneksel el sanatları arasında unutulmaya yüz tutmuş olanların ortaya çıkarılması, varlığını sürdürenlerin korunarak gelecek nesillere aktarılması, sürdürülebilir turizm aracılığıyla mümkün olabilmektedir. Bu çıkış noktasından hareketle çalışmanın amacı, sürdürülebilir turizm felsefesi doğrultusundageleneksel el sanatları ürünlerinin mevcut durumunun irdelenmesi ve “Somut Olmayan Kültürel Miras Türkiye Ulusal Envanteri” içerisinde yer almayan ancak Hatay’da ön plana çıkan geleneksel el sanatlarının ortaya çıkarılmasıdır. Çalışmada nitel araştırma yöntemi kullanılmış olup, veriler 15 katılımcı ile gerçekleştirilen yapılandırılmış görüşmeler sonucunda elde edilmiştir. Çalışma bulgularına göre Hatay’a ait envanter listesinde yer almayan on dört (14) farklı geleneksel el sanatı tespit edilmiştir. Tespit edilen geleneksel el sanatlarının Somut Olmayan Kültürel Miras Türkiye Ulusal Envanterine dâhil edilerek korunması önerilmektedir. Bu çalışma, 16-18 Haziran 2022 tarihleri arasında gerçekleştirilen IWACT Kongresinde, dar kapsamlı haliyle bildiri olarak sunulmuş olup, özet bildiri kitapçığında yer almaktadır.
Turistlerin Yerel Mutfak Yeme Eğilimleri ile Unutulmaz Turizm Deneyimleri Arasındaki İlişki: Kayseri Örneği (The Relat ionship Between Local Cuisine Eating Tendencies of Tourists and Their Memorable Tourism Experiences: The Case of Kayseri)
Authors: Çeşmeci Nihat , Çulfacı Gözde , Kılıçhan Reha
Published: March 2023

Bu çalışmanın amacı, turistlerin yerel mutfak yeme eğilimleri ile unutulmaz turizm deneyimleri arasındaki ilişkiyi değerlendirmek ve bu konuda mevcut literatürdeki bilgi eksikliğine katkıda bulunmaktır. Bu amaç doğrultusunda, öncelikle detaylı literatür taraması sunulmuş, ardından araştırma sorularına yer verilmiştir. Alan araştırması kapsamında veri toplama aracı olarak anket yöntemi kullanılmıştır. Birincil veriler, 1-30 Kasım 2022 tarihleri arasında, bizzat araştırmacılar tarafından anketi doldurmaya gönüllü ve yiyecek içecek işletmeleri ile konaklama işletmelerinin restoranlarından hizmet alan toplam 329 ziyaretçiden yüz yüze ve bırak-topla yöntemleri kullanılarak toplanmıştır. Kolayda örnekleme tekniği kullanılarak toplanan bu veriler, tanımlayıcı istatistikler, faktör, korelasyon ve regresyon analizleri, bağımsız örneklem t-testi ve ANOVA gibi analizlerle analiz edilmiştir. Araştırmanın en çarpıcı bulgusu turistlerin yerel mutfak yeme eğilimleri ile unutulmaz turizm deneyimleri arasında pozitif yönlü bir ilişkinin tespit edilmesidir. Ayrıca turistlerin demografik özelliklerine ve seyahat deneyimlerine göre birtakım farklılıklar da tespit edilmiştir.
Kış Turizmi Kapsamında Uludağ, Palandöken ve Sarıkamış Destinasyonlarındaki Otellere 2016-2021 Yılları Arasında Yapılan Çevrimiçi Şikâyetlerin Karşılaştırılması (Comparison of Online Complaints Made to Hotels in Uludağ, Palandöken and Sarikamiş Destinations Between 2016-2021 Within the Scope of Winter Tourism)
Authors: Satık Özge , Gençer Kansu
Published: March 2023

Günümüz tüketicileri bir mal veya hizmet satın alma kararlarında daha önce o ürünü satın alarak tecrübe edinmiş kişilerin yaptıkları yorumlardan faydalanmaktadır. Rekabetin hızla arttığı turizm sektöründe konaklama işletmeleri açısından çevrimiçi ortamda yapılan yorumlar söz konusu işletme hakkında tüketicinin fikir sahibi olmasını sağladığı için büyük öneme sahiptir. Tüketici bunları inceleyerek karar verme ve satın alma işlemlerini gerçekleştirmektedir. Bu çalışmada Bursa Uludağ’daki, Erzurum Palandöken’deki ve Kars Sarıkamış’taki 5 yıldızlı otellerin çevrimiçi ortamda müşteriler tarafından aldığı olumsuz yorumların incelenmesi ve karşılaştırılması amaçlanmıştır. TripAdvisor internet sitesinden Uludağ’da 2 otele yapılan toplam 1535 yorumdan 243 şikâyet, Palandöken’de 3 otele yapılan toplam 868 yorumdan 261 şikâyet Sarıkamış’ta 2 otele yapılan toplam 336 yorumdan 174 şikâyet incelenmiş ve değerlendirilmiştir. Uludağ otellerinde en çok şikâyet yemeklerden, Palandöken’de otellerin iç mimarisinin ve odaların eskiliğinden alınırken, Sarıkamış’ta personel hizmeti ve yetersizliğinden şikâyet alındığı tespit edilmiştir. Bu bulgular doğrultusunda şikâyet sayıları farklı olduğundan karşılaştırma bulguları yüzde şeklinde verilmektedir. Çalışma, Türkiye’de popüler olan bu kış turizmi destinasyonlarındaki 5 yıldızlı otellerin eksikliklerinin giderilmesi ve gelecekte yapılacak olan yatırımlar açısından bilgi verici niteliktedir. Sunulan öneriler açısından sektöre ve literatüre katkı sağlaması beklenmektedir. Türkiye’de turizmin çeşitlendirilmesi ve mevsimsellik açısından yaz mevsimine alternatif olarak kış mevsiminde iç ve dış turist sayısının ve gelirlerin arttırılmasının destinasyonların rekabete dayalı iyileştirmeler ile de teşvik edilebileceği düşünülmektedir.
Yavaş Şehir Algısı ve Turizmin Etkilerinin Yerel Halkın Yaşam Doyumuna Etkisi (The Perception of The Slow City and The Effects of Tourism on The Life Satisfaction of The Local People)
Authors: Salı Öztürk Shırın , Sünnetçioğlu Ayşe
Published: March 2023

Bu çalışmanın amacı Uluslararası Cittaslow ünvanına sahip olan ve son dönemlerde seyahat için tercih edilen önemli bir turizm destinasyonu haline gelen Gökçeada’nın yerel halkının yaşam doyumunda yavaş şehir algısı ve turizm etkilerinin rolünün ne olduğunu ortaya koymaktır. Bu amaçla araştırmanın verileri 12 Mayıs - 15 Haziran 2022 tarihleri arasında Gökçeada merkez ve köylerinde yaşayan 380 katılımcı ile çevrimiçi ve yüz yüze anket yoluyla toplanmıştır. Araştırma kapsamında elde edilen verilerin analizinde, geçerlilik analizi, güvenirlik analizi, korelasyon analizi, regresyon analizi, frekans analizi, aritmetik ortalama ve standart sapma analizi kullanılmıştır. Araştırmada elde edilen verilerin analiz sonuçlarına göre, yaşam doyumu tek boyutlu, yavaş şehir algısı (refah, doğal çevre, sosyal yaşam ve kültürel) olarak dört boyutlu ve turizmin etkileri (kirlilik, ekonomik, kültürel ve refah) olmak üzere dört boyutlu olarak belirlenmiştir. Araştırmada yavaş şehir algısının “doğal çevre” boyutu ile turizmin etkilerinin “kültürel” boyutunun yerel halkın yaşam doyumu üzerinde olumlu bir etkisi olduğu sonucuna ulaşılmıştır.
National Security Policy Options For Cyber Ecosystem Resilience
Authors:   , Acworth Flynn
Published: March 2023

National cyber insecurity is a wicked problem that threatens states’ societies, economies, polities, and natural security. In a world of increasing digital dependence, it is essential that states are resilient to the threats targeting and originating from their use of cyberspace. This research uses the metaphor of an ecosystem to conceptualize states’ use of and influence over cyberspace, and identifies four key threats facing cyber ecosystems – critical infrastructure attacks, disinformation campaigns, financially motivated cybercrime and attempts to influence Internet governance. The concept of cyber ecosystem resilience is then defined, and a framework is outlined that can be used by states to identify and implement national security policies that enhance resilience against the identified cyber threats. The value of this framework is then demonstrated by applying it to the identification of a suite of policy options available to states to enhance ecosystem resilience against the two threats of critical infrastructure attacks and disinformation campaigns.
Analysis on Developing English Speaking Through Reading in Junior Middle Schools
Authors: Liu Runhong
Published: March 2023

In terms of English education, much research has been done on the combination of reading and writing, but there are relatively few studies on the combination of reading and speaking. In this study, the combination of reading and speaking in English through activities was expounded. The effect of this teaching mode was studied based on students’ understanding of the subject, practical application, and transfer of knowledge. The goal of this teaching mode is to develop students’ core literacy and to enable them to interpret and utilize text resources. With these as objectives, teachers can design lessons and evaluations that require students to verbally explain what they understand after reading lessons and guide students in a stepwise manner, from superficial text understanding to in-depth understanding and eventually to thinking beyond text learning, so as to promote the integration and development of students’ language skills, cultural awareness, thinking, and learning ability.
Heart rate, a poor predictor of Pulmonary Embolism
Authors: Fernando Melinda , Gondal Faris , Meyer Alastair , Pouryaha Pourya
Published: March 2023

Objective: To determine if there is a significant difference in vital signs between patients with confirmed and excluded pulmonary embolism (PE) throughout their Emergency Department presentation. Methods: We conducted a retrospective cohort study with patients presenting with suspected PE to Monash Health Emergency Departments between July 2014 and July 2019. Vital signs were compared between patients with confirmed or excluded PE as determined by imaging (CTPA or VQ). Vital signs were compared at three unique data points: initial, minimum, and maximum values. Results: 3549 patients met inclusion criteria, 922 with confirmed PE and 2627 with excluded PE based on CTPA or VQ. Patients with PE had significant elevations in mean respiratory rates, systolic blood pressures and reduced oxygen saturations compared to patients without PE. Heart rate was not significantly different at initial and maximum datapoints. Conclusion: Vital signs were demonstrated to be poor predictors of acute PE. Receiver operating characteristic curve analysis suggests that heart rate has poor discriminative power. AUC values for heart rate were: 0.516 (initial), 0.549 (maximum) and 0.519 (minimum). Furthermore, 95% of patients with confirmed PE did not exceed heart rates of 100 BPM during presentation to Emergency. The utility of elevated heart rate and other vital signs in predicting PE were not substantiated in this study.
Long-Term Pharmacological and Psychosocial Outcomes of Adolescent-Onset Epilepsy: A Single-Center Experience
Authors: Kim Hyun-Jin , Jang Han Na , Ahn Hyun-Ji , Yum Mi-Sun , Ko Tae-Sung
Published: March 2023

Purpose: Despite the high incidence of epilepsy during adolescence, little attention has been paid to the outcomes and prognosis of adolescent-onset epilepsy. The aim of this study was to investigate the long-term pharmacological and psychosocial outcomes of adolescent-onset epilepsy.Methods: From 1993 to 2019, the electronic medical records of adolescent-onset epilepsy patients were retrieved from Asan Medical Center Children’s Hospital. Seizure outcomes were evaluated based on the seizure-free period at last contact. Possible predictors of remission, relapse, and intractability were investigated. Neuropsychiatric comorbidities, socioeconomic status, and transition outcomes were also assessed. Results: In total, 137 patients were enrolled in this study. The median age at diagnosis of epilepsy was 14 years and the mean duration of therapy was 13.0 years. During follow-up, 93 patients (67.9%) achieved terminal remission, of which 27 cases (19.7%) resolved. Relapse after withdrawal of medication occurred in 74 patients (54.0%), and the presence of electroencephalographic abnormalities (odds ratio [OR], 8.23; 95% confidence interval [CI], 1.39 to 48.87; P=0.020), poor adherence (OR, 4.84; 95% CI, 2.13 to 11.02; P=0.000), and history of febrile seizures (OR, 4.10; 95% CI, 1.21 to 13.93; P=0.024) were risk factors for relapse. Neurodevelopmental and psychological comorbidities were documented in 17 (12.4%) and 12 (8.8%) patients, respectively. Thirty-six (26.3%) patients transferred to adult clinics, at a mean age of 21.9 years. Conclusion: This study showed overall favorable seizure outcomes with a high rate of remission, but with frequent relapse after withdrawal.
Fake News Detection System: An implementation of BERT and Boosting Algorithm
Authors: Sultana Raquiba , Nishino Tetsuro
Published: March 2023

On social media, false information can proliferate quickly and cause big issues. To minimize the harm caused by false information, it is essential to comprehend its sensitive nature and content. To achieve this, it is necessary to first identify the characteristics of information. To identify false information on the internet, we suggest an ensemble model based on transformers in this paper. First, various text classification tasks were carried out to understand the content of false and true news on Covid-19. The proposed hybrid ensemble learning model used the results. The results of our analysis were encouraging, demonstrating that the suggested system can identify false information on social media. All the classification tasks were validated and shows outstanding results. The final model showed excellent accuracy (0.99) and F1 score (0.99). The Receiver Operating Character- istics (ROC) curve showed that the true-positive rate of the data in this model was close to one, and the AUC (Area Under The Curve) score was also very high at 0.99. Thus, it was shown that the suggested model was effective at identifying false information online.
Adaptive Fair and Cost-Effective Load Balancing in Distributed Computing Systems
Authors: Penmatsa Satish , Penmatsa Krishna Kanth Varma
Published: March 2023

Load balancing is one of the main challenges in distributed computing systems such as the cloud computing systems. It helps improve throughput while reducing the response time and cost for data and computation intensive applications. In this paper, we present an adaptive load balancing scheme for heterogeneous distributed computing systems whose objective is to provide a fair allocation of jobs to computing resources that reduces the cost of executing the jobs in the system. Using simulations, we compare the performance of the presented scheme with that of existing load balancing schemes.
Investigation of the possibilities of using oleaster fruit flour in the production of low-fat- low-cholesterol mayonnaise
Authors: ÜNVER Naciye , ÇELİK Şerafettin , SAYAR Sema , ERGÜN Berfin , YAKAR Yasin
Published: March 2023

The aim of the study is to investigate the possible usage of oleaster fruit flour (OFF) (Elaeagnus angustifolia) in mayonnaise formulation by reducing the fat and egg yolk ratios. Mayonnaise samples with four different formulations as control, low-fat low-cholesterol mayonnaise-I (LFCM-I), low-fat low-cholesterol mayonnaise-II (LFCM-II) and low-fat low-cholesterol mayonnaise-III (LFCM-III) were produced. The oil, egg yolk and sugar ratios were decreased with the incremental percentage of OFF. The substitution of egg yolk and fat in the mayonnaise formula by the addition of OFF caused an increase in pH value, viscosity, firmness, consistency and work of shear, whereas a decrease in the acidity, total cholesterol content, peroxide value, TBARs value and conjugated dienes ratio. Considering all of the physical and chemical analysis results, the OFF can be used as a fat and egg yolk substitute in the mayonnaise formula; however, it was concluded that the mayonnaise-like sauce, which has higher emulsion stability and better physical characteristics, can be obtained by combining OFF with various stabilizers.
Potential Characteristics Of Biopori Absorption In Mandalika Terminal Area
Authors: Jaya Negara I Dewa Gede , Supriyadi Anid , Alit Karyawan I Dewa Made , Suroso Agus , Hanifah Lilik , Azmi Muhammad Khoirul
Published: March 2023

Pengembangan ekonomi masyarakat di Kota Mataram sudah semakin menggeliat dengan berkembangnya pembangunan Terminal dan  Pasar Mandalika saat ini. Pembangunan tersebut menimbulkan perubahan fungsi lahan sawah menjadi aspal atau beton dan hal ini telah mengurangi daerah resapan wilayah hulu Kota Mataram. Perubahan fungsi lahan tersebut telah meningkatkan jumlah limpasan didaerah sekitarnya saat musim hujan sehingga sering terjadi genangan-genangan dan perlu ditangani. Studi ini bertujuan mengetahui karakteristik peresapan dengan lubang resapan biopori (LRB) yang dibandingkan dengan klasifikasi Uhland and O,Neal,1951 dan  potensinya.Uji biopori dilakukan pada lahan 0,3844 ha dengan  6 titik uji yang terdiri dari  1 uji kontrol dan  5 uji biopori perlakuan dengan sampah organik, dengan panjang pipa PVC biopori 60 cm berdiameter 10 cm. Kemampuan resapan LRB uji dan kontrol memiliki kemampuan infiltrasi termasuk sangat cepat dengan  dua potensi infiltrasi yaitu 80cm/jam – 100 cm/jam dan 200 cm/jam – 250 cm/jam. Laju resapan  konstan diperoleh pada durasi 60 menit untuk semua LRB.
PERBANDINGAN RESPON SEISMIK STRUKTUR GEDUNG SISTEM KONVENSIONAL DENGAN SISTEM ISOLASI DASAR (STUDI KASUS: GEDUNG TEMPAT EVAKUASI SEMENTARA, BANGSAL, KABUPATEN LOMBOK UTARA)
Authors: Kencanawati Ni Nyoman , Aprianingsih Lia , Hariyadi Hariyadi , Ngudiyono Ngudiyono , Mahmud Fathmah , Widianty Desi
Published: March 2023

Indonesia merupakan negara yang memiliki potensi gempa tinggi, untuk itu perlu usaha mereduksi dampak yang timbul akibat gempa terutama pada struktur bangunan. Struktur yang dianalisis adalah gedung Tempat Evakuasi Sementara (TES) yang berada di Bangsal, Lombok Utara.  Gedung ini terdiri dari 4 lantai dan akan dilakukan analisis tiga dimensi pada struktur fixed base dan struktur yang menggunakan base isolator bertipe lead rubber bearing (LRB), friction pendulum system (FPS) dan high damping rubber bearing (HDRB). Berdasarkan hasil analisis didapatkan diameter isolator tipe LRB dan HDRB sebesar 750 mm, sementara diameter FPS sebesar 1180 mm. Dengan menggunakan base isolator terjadi peningkatan periode struktur untuk tipe LRB, FPS dan HDRB berturut-turut sebesar 1,812 detik; 1,957 detik dan 1,435 detik. Terjadi juga peningkatan pada simpangan dasar arah x dan y pada tipe LRB, HDRB dan FPS, yakni berturut-turut sebesar 96,42%; 96,99%; 94,15% dan 93,84%; 93,16%; 89,97%. Sementara itu, terjadi penurunan pada simpangan antar lantai arah x berturut-turut sebesar 64,2%; 63,73%, 64,7% dan arah y sebesar 60,65%; 62,61%; 56,67%. Base isolator tidak langsung menyentuh pondasi melainkan dihubungkan dengan kolom pedestal yang berdiameter 1500 mm dengan tulangan 54 D25. Sementara itu untuk menghubungkan antara isolator dengan kolom pedestal digunakan base plate dengan tebal 20 mm dan panjang baut angkur sebesar 700 mm. Hasil analisis menunjukkan penggunaan base isolator dapat secara efektif memperbaiki respon struktur terhadap bahaya gempa, pada kasus ini pada gedung berlantai 4.
EVALUASI PENYIMPANGAN DATA HUJAN SATELIT TRMM JAXA DALAM ANALISIS CURAH HUJAN RANCANGAN DI WILAYAH SUMBAWA
Authors: Saidah Humairo , Setiawan Agustono , Setiawan Ery , Salehudin Salehudin
Published: March 2023

Pemanfaatan data hujan satelit sebagai salah satu alternatif penyedia jasa semakin dirasakan manfaatnya, utamanya bagi daerah yang memiliki stasiun penakar hujan terbatas. Salah satu satelit penyedia data hujan yang cakupan wilayahnya termasuk Indonesia adalah TRMM JAXA. Penelitian ini menguji seberapa jauh kedekatan data hujan dari TRMM JAXA dibandingkan data hujan pengukuran. Tahapan dimulai dengan mengumpulkan data hujan dilanjutkan dengan perhitungan hujan rancangan, dan mengukur penyimpangannya dengan nilai RMSE dan BIAS. Hasil yang diperoleh menunjukkan bahwa data hujan dari satelit TRMM JAXA di Wilayah Sumbawa cenderung underestimate dan memiliki tingkat akurasi yang cukup dibandingkan data hujan pengamatan dengan penyimpangan rerata sebesar -0.05. Besaran hujan rancangan yang dihasilkan dari analisis frekuensi menggunakan data hujan satelit TRMM JAXA memiliki penyimpangan yang cukup besar yaitu sebesar 21%.
Modelación de predictores de precio nominal vs real aplicados a maíz, trigo y cebada en México
Authors: Martínez-Damián Miguel Angel , Brambila-Paz José de Jesús
Published: March 2023

En la producción agrícola, el desfase en el tiempo entre el momento que se asignan recursos y se obtienen recursos hace necesario generar una predicción en el momento t (siembra), del precio vigente en t + j (venta). Sin embargo, en presencia de inflación, es posible que el tomador de decisiones opte por hacer una predicción en términos nominales o bien descuente dicha inflación. Con precios mensuales, bajo un enfoque de series de tiempo y tras ajustar un modelo IMA (1, 1), se investigó esta disyuntiva para el caso del maíz, trigo y cebada en México. Después de comparar seis criterios de bondad de ajuste para cada alternativa de predicción en cada cultivo para el periodo analizado 2002 a 2019, se encuentra que el empleo de datos nominales o reales es indiferente en la construcción del predictor de precio.
Inducción de embriones androgénicos y regeneración de plantas haploides en genotipos experimentales de chile poblano a través de cultivo de anteras
Authors: González-Chavira Mario Martín , Guerrero-Aguilar Brenda Zulema , Pons-Hernández José Luis , Escobedo-Landín María de los Ángeles , García-Reyna José Francisco , Mora-Avilés María Alejandra
Published: March 2023

Los métodos tradicionales para obtener líneas puras u homocigotas involucran varias generaciones de autofecundación con un requerimiento importante de tiempo. La obtención de plantas haploides y doble haploides, representa una alternativa que reduce a una generación, la producción de líneas con alelos idénticos en todos sus cromosomas. El objetivo de este trabajo fue implementar el protocolo de obtención de embriones androgénicos en poblaciones de chile mulato y ancho del programa de mejoramiento de chile en el Campo Experimental Bajío del Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias durante 2019 y 2020. Treinta genotipos de chile comprendidos en dos poblaciones. a) población criolla heterogénea de chiles mulato y ancho con característica de esterilidad masculina citoplasmática; y b) población de cruzas interespecíficas de chile ancho con chile habanero (C. annuum x C. chinense) resistentes a geminivirus (PepGMV) y Phytophthora sp., fueron sometidas a tratamiento de inducción androgénica. El tratamiento consistió en N 6 -furfuriladenina (cinetina) (0.01 mg L-1) y ácido 2,4-diclorofenoxiacético (2,4-D) (0.01 mg L-1) para la inducción de embriogénesis somática y posteriormente de cinetina (0.1 mg L-1) para la inducción de germinación de embriones. La duplicación cromosómica se realizó por medio de colchicina (0.5%) previo a su adaptación in vivo. La población conformada por genotipos derivados de cruzas interespecíficas obtuvo mayor eficiencia de plantas regeneradas doble haploides entre 4.29% y 14.67%, mientras que la población criolla generó embriones en menor proporción entre 1.02% y 5.26%. Estos resultados son los primeros reportados para obtención de plantas doble haploides de chiles mulato y ancho.
População LGBTQIA+ em cárcere: sobre direitos, intersecções, singularidades e as práxis profissionais.
Authors: Guedes Iêda Maria Louzada
Published: March 2023

Constitui objetivo do estudo analisar as contribuições das atividades sobre população LGBTQIA+ no cárcere, para a formação e atuação em saúde. Estudo descritivo/qualitativo, com a análise de mesas de debates realizadas, em 2021, pelo PET Medicina Enfermagem. A vivência propiciou ampliação de conhecimentos e percepção sobre precarização da vida da população, de modo a sensibilizar, quanto ao acolhimento, cuidado e a garantia de direitos. O contato com conhecimento contextualizado permitiu reflexão crítica sobre condições de existência dos sujeitos e as violências estruturais, no cárcere. Conclui-se que a aproximação da realidade contribuiu com desenvolvimento de competências para práxis, atentas às singularidades, visando um fazer comprometido com universalidade, equidade e integralidade.
AVALIAÇÃO DOS SERVIDORES DO PODER JUDICIÁRIO DO MARANHÃO: DA INEFICIÊNCIA DO MODELO ATUAL PARA UMA PROPOSTA COM BASE NA GESTÃO DO DESEMPENHO POR COMPETÊNCIA
Authors: Costa Liana Rachel Bandeira , Silva Rodrigo Ericeira Valente da
Published: March 2023

A Gestão de Pessoas que ocorre em instituições públicas tem em seu processo de avaliação de desempenho um modelo de aplicação de instrumentos quantitativos que são pouco utilizados para desenvolvimento institucional. No caso específico do Tribunal de Justiça do Maranhão é empregada para fins de aprovação de estágio probatório, progressão e promoção funcional e pagamento de gratificações, tendo em vista que o processo engloba apenas os servidores efetivos. O objetivo deste trabalho é detectar a percepção dos servidores e gestores sobre o modelo atual adotado pelo poder judiciário estadual, identificando as dificuldades e os desafios enfrentados. Para realização deste estudo foi utilizada como metodologia a pesquisa quantitativa e qualitativa com revisão bibliográfica, documental e estudo de caso. Os resultados revelaram insatisfação com o atual modelo de avaliação utilizado no Tribunal de Justiça. Conclui-se que a instituição tem como problema principal identificado pelos servidores o formato do formulário utilizado, que segundo os funcionários não condiz com a realidade dos mesmos, pois não aborda a questão da competência.

Palavras-chave: avaliação desempenho; poder judiciário; gestão; competência.
ANÁLISE DA IMPARCIALIDADE FRENTE AO JUIZ DAS GARANTIAS SOB A ÓTICA DOS DIREITOS FUNDAMENTAIS
Authors: Porto Rosângela Lopes da Silva , França Lucylea Gonçalves , Coelho Júnior Alcides de Sousa
Published: March 2023

A repercussão trazida pelo “Pacote Anticrime” (Art. 3º, Lei 13.964/19), mais precisamente com a inovação do Instituto do Juiz das Garantias, despertou a necessidade de analisar a imparcialidade do julgador sob a ótica dos direitos fundamentais. O objetivo principal desta pesquisa bibliográfica foi identificar, dentro do atual sistema processual penal, se o princípio da imparcialidade está sendo exercido, bem como se os direitos do acusado estão sendo assegurados. No resultado restou inquestionável que o atual modelo do sistema processual penal impossibilita a imparcialidade do magistrado, visto que este, acaba levando consigo um pré-julgamento, por participar tanto da fase da persecução penal quanto da instrução e julgamento.

Palavras-chave: imparcialidade; juiz das garantias; direitos fundamentais; pacote anticrime.
OS EFEITOS DA PANDEMIA NAS ROTINAS DE TRABALHO DAS UNIDADES JUDICIAIS DA COMARCA DE CAXIAS NO ANO DE 2020
Authors: Leite Vilna Vadja Barbosa , Moreira Francisco Gilvan Lima
Published: March 2023

O presente artigo investigou os efeitos provenientes da pandemia de Covid 19 que atingiu o mundo inteiro a partir de 2020, especificamente nas rotinas de trabalho das Unidades Judiciais e Administrativas do Fórum Des. Arthur Almada Lima, na Comarca de Caxias. A metodologia aplicada neste estudo, alicerçou-se em pesquisa bibliográfica e documental acerca das regulamentações necessárias para a implementação do regime de plantão extraordinário no judiciário maranhense, conjugada a uma pesquisa de campo por meio de questionário, composto por 9(nove) perguntas, direcionado aos gestores de cada unidade. A coleta de dados, realizada em junho de 2021, cuidou de averiguar as mudanças provocadas na Gestão dos Processos Internos, a partir da inserção do trabalho remoto como novo regime de funcionamento do judiciário maranhense. A pandemia de Covid-19 pôs a prova toda essa nova estrutura moldada nos preceitos constitucionais. Além disso, revelou a importância do papel do gestor na condução das demandas e na solução dos problemas decorrentes do ineditismo do momento. Um fator a ser destacado, é quanto ao modelo de trabalho mais indicado pelos gestores, onde apenas 9% (nove por cento) optaram pelo modelo presencial, outros 9% (nove por cento) pelo modelo de trabalho remoto e majoritariamente 82% (oitenta e dois por cento) preferem o modelo híbrido. Tudo isso possibilitado pelo advento da tecnologia presente no mundo do trabalho, que adentrando nos lares dos servidores, estabeleceu um novo formato de trabalho: o home office.

Palavras-chave: Covid-19; trabalho remoto; gestão de processos internos.
GESTÃO DE PESSOAS, GESTÃO DE CONHECIMENTOS E SISTEMA DE MERITOCRACIA NO ÂMBITO DO PLANO DE CARGOS, CARREIRAS E VENCIMENTOS DO TRIBUNAL DE JUSTIÇA DO MARANHÃO: APONTAMENTOS SOBRE A EFETIVIDADE NA PRESTAÇÃO JURISDICIONAL
Authors: Sousa Clemilton Ferreira , França Lucylea Gonçalves
Published: March 2023

O presente trabalho pretende analisar o Plano de Cargos, Carreiras e Vencimentos dos Servidores do Tribunal de Justiça do Estado do Maranhão implementado através da Lei no 8.715 de 19 de novembro de 2007 e, estudar e compreender a eficácia do sistema de Gratificação de Atividade Judiciária, de acordo com as metas e necessidades estabelecidas no marco do Poder Judiciário. A abordagem compreende verificar através de relatórios, dados e pesquisas, a necessidade de um mapeamento da cultura organizacional do Tribunal de Justiça do Estado do Maranhão e suas possíveis implicações práticas em cada unidade administrativa e jurisdicional. Seguindo esse contexto, discorre-se sobre a Gestão de Pessoas e Gestão de Conhecimentos, visando a necessidade de subsidiar a formulação de políticas que contemplem servidores qualificados no desenvolvimento das atividades individuais de acordo com as necessidades dos setores específicos, vislumbrando a produtividade por meio da gratificação em percentual adequado ao resultado final. Ademais, na forma da Lei n. 8.715/2007, aborda-se sobre a reorganização do PCCV como instrumento de regularização e reestruturação do sistema de Gestão de Competências e Meritocracia do Poder Judiciário Estadual do Maranhão. Portanto, o fomento que visa alcançar, será uma reorganização e ampliação de importante mecanismo de qualificação, progressão e promoção de servidores, por meio de um sistema de meritocracia profissional, de acordo com as atividades exercidas, atrelados ao novo projeto de lei que dispõe sobre o Plano de Cargos, Carreiras e Vencimentos dos Servidores do Poder Judiciário do Maranhão.

Palavras-chave: gestão; competências; meritocracia; produtividade; qualificação.
GESTÃO DE RISCOS NO JUDICIÁRIO: APLICAÇÃO DA METODOLOGIA COM GUIA NA TOMADA DE DECISÕES
Authors: Soares Djanne de Oliveira , Silva Rodrigo Ericeira Valente
Published: March 2023

O presente trabalho pretende abordar sobre aplicação da metodologia de Gestão de Riscos no judiciário influenciando na tomada de decisões estratégicas efetivas. Neste sentido, essa pesquisa justifica-se em uma abordagem que compreende o conceito da Teoria da Racionalidade Limitada, desde as teorias preliminares da década de cinquenta do economista estadunidense Herbert Alexander Simon, até as ideias conceituais contemporâneas de gestão de riscos, formando assim, as bases conceituais para a implantação da gestão de riscos no Tribunal. Dessa forma, a metodologia centra-se na pesquisa bibliográfica, além de abordagem sobre o Planejamento Estratégico como auxílio na sistematização dos objetivos estratégicos que subsidiarão os gestores na implantação da gestão de riscos pautados nas metas, objetivos, indicadores, assim como, na mitigação de riscos organizacionais. Os resultados evidenciaram que, por meio da avaliação e o monitoramento dos resultados do Planejamento Estratégico, define-se um alinhamento com um Plano de Implantação da Gestão de Riscos, roteirizando o passo a passo de um projeto de gestão de riscos em uma organização judiciária. Por fim, concluímos que a aplicação de um projeto de gestão de riscos devidamente estruturado em formato de comitês tendo a alta gestão do Tribunal como patrocinador principal, contribui para a tomada de decisões eficazes culminando no gerenciamento e governança do serviço público.
Palavras-chave: racionalidade limitada; gestão de riscos; planejamento estratégico.