bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF IMMUNOHISTOCHEMICAL REACTIONS OF VARIOUS PD-L1 CLONES IN PROSTATE ADENOCARCINOMA
Authors: M.A. Kalfa, , E.P. Golubinskaya, , T.P. Makalish, , E.Yu. Zyablitskaya, , A.V. Kubyshkin,
Published: December 2022

Prostate cancer (PC) is the most commonly diagnosed malignancy in men. The standard treatment for localized PC is radical prostatectomy, but recurrence is a significant problem in this case. The main prognostic markers of the disease recurrence are the Gleason score and the preoperative level of the prostate-specific antigen (PSA), which determines the need to identify some key molecules of the PC progression. This can be useful in identifying new prognostic markers or targeted treatments for this pathology.
A NEW MUTATION IN THE PALB2 GENE ASSOCIATED WITH HEREDITARY BREAST CANCER IN A YOUNG PATIENT BELONGING TO THE YAKUT ETHNIC GROUP
Authors: A.Yu. Molokov, , P.A. Gervas, , A.A. Zarubin, , D.G. Tikhonov, , N.V. Cherdyntseva,
Published: December 2022

Breast cancer is the most common cancer worldwide. The oncosuppressor gene PALB2, along with such genes as BRCA1 and BRCA2, is involved in the repair of damaged DNA. The incidence of germline mutations in the PALB2 gene in breast cancer and in familial cases of pancreatic cancer is approximately 1–2% and 3–4%, respectively. A clinical case of a 39-year-old woman belonging to the Yakut ethnic group, diagnosed with breast cancer and with a family history of pancreatic cancer, is presented hereby.
INTERMITTENT FASTING AND INTERVAL HYPOXIC TRAINING FOR ACTIVATION OF ADAPTIVE RESERVES OF THE BODY, PREVENTION AND TREATMENT OF DEGENERATIVE BRAIN DISEASES
Authors: T.N. Voronina,
Published: December 2022

Degenerative brain diseases (DBD) and other cognitive dysfunctions may appear due to the depletion of adaptive reserves as a result of aging, stress, depression, and other pathological processes (inflammation, malignant neoplasms). The depletion of the adaptive reserves leads to disordering accurate, appropriate signaling in the brain, between the brain and the body, as well as disorders at the levels of the organs, cells and molecules.
Investigation of the Effects of Optical Models on the Production Cross–Section Calculations of 22,24Na Radioisotopes with some (d,x) and (α,x) Reactions
Authors: ŞEKERCİ Mert
Published: December 2022

It is well recognized that the outcomes of investigations conducted in the field of basic sciences, as well as the achievements gained over the period of these studies, mediate effective and useful outcomes not only for basic sciences, but also for many other fields as diverse from engineering to medicine. In this regard, theoretical researches on the production routes of various radioisotopes that could be implemented in a numerous of fields ensure that physics and other associated areas interact on a common ground. Taking this fact into account as the motivation, the goal of this study is set to investigate how various deuteron and alpha optical models impact the cross–section calculations of 22,24Na radioisotopes, which are known to be utilized in medical applications. The TALYS (v1.95) code was utilized in the calculations, which allows for the use of five different deuteron and eight different alpha optical model alternatives. The obtained results were not only visually compared to the existing experimental data in the literature, but also quantitatively by performing mean weighted deviation and relative variance analyses.
Islamic Education and Intention of Sharia Stock Investment in Pandemic COVID-19: The Role of Islamic Motivation As Mediating Variable
Authors: Kholmi Masiyah , Oktavendi Tri Wahyu
Published: December 2022

Research aims: This study aims to examine the mediating role of Islamic Motivation on the relationship between Islamic Education and the Intention of Sharia Stock Investment during the COVID-19 Pandemic.Design/Methodology/Approach: This research using purposive sampling method with 101 observations of students at University of Muhammadiyah Malang. The data was tested using Smart PLS through several tests, such as Outer Model, Inner Model and Hypothesis Testing.Research findings: The results showed that Islamic education had no effect on Intention of Sharia Stock Investment, but had an effect on Islamic motivation. Islamic motivation influences the intention of sharia stock investment. Furthermore, Islamic Motivation is also able to mediate the relationship between Islamic Ecation and Intention of Sharia Stock Investment. Thus the mediation that occurs is full.Theoretical contribution/Originality: This research can be essential information for higher education in the Intention of Sharia Stock Investment, especially in the COVID-19 Pandemic.Research Implication: This research has implications for policies in the field of education, especially universities in generating investors in Islamic stocks by strengthening understanding and developing Islamic education and Islamic stock investment skills for students.
Determinants of Financial Decisions of Millennial Generation in Islamic Banking: Does Islamic Branding Matter?
Authors: Djazuli Abid , Ab Aziz Muhammad Ridhwan , Candera Mister , Yanti Darma
Published: December 2022

Research aims: This study aims to determine the financial decisions of the millennial generation by considering the Islamic financial literacy variables, reflected by the financial behavioral, knowledge, and attitude variables, and Islamic branding as a mediating variable.Design/Methodology/Approach: The approach used in this study was empirical. Utilizing questionnaires distributed through various online media, the data were collected. The research samples included the millennial generation in South Sumatra, filtered using a purposive sampling technique. To evaluate the hypotheses, Structural Equation Modeling (SEM) was employed. Research findings: The study findings highlighted that Islamic financial literacy directly had a positive and significant impact on the financial decisions of the millennial generation in South Sumatra. Islamic branding could also mediate (partial mediation) the influence of Islamic financial literacy on financial decisions. Theoretical contribution/Originality: This finding can be used as a reference for companies to increase the number of customers and investors, especially among the millennial generation. Specifically, Islamic branding can be recommended as one of the sharia banking business strategies to improve the financial decisions of the millennial generation.Research limitation/Implication: This study was only conducted in South Sumatra, making the result not quite strong in terms of external validity.
Al-Ghazālī’s Perspective of Salam and Its Relevance to E-Commerce in Nigeria
Authors: Shuaib Assayouti Jalaludeen , Badmus Suraju Saheed
Published: December 2022

The growth of the basic needs and wants of man takes place alongside man’s response to civilization. By way of economic civilization in Nigeria, the mode of the business transaction has had its extension stretched from onsite to online, which has the internet space as its platform in a bid for globalization. There is no doubt that there is a plethora of anomalies; the obscurity of intentions, excessive uncertainties -gharar, as well as day-light robbery from both ends of the buyers and sellers in the online business space. Thus, this paper is aimed at examining the basic position of Islām on the business transaction in general, with a move to unraveling the prospects and challenges of implementing salam on e-commerce, i.e., online business, as discussed by Imām Abū Ḥāmid Al-Ghazālī in his Iḥyā’u cUlūmi-d-Dīn. The methodologies adopted are; descriptive, which enhanced adequate presentation of the ways and manners online business is being operated, and analytical, which aided the study in analyzing Al-Ghazālī’s views in relation to the Nigerian online business sphere. It was revealed that defrauding, the major problem associated with e-commerce in Nigeria, is blamable on the parts of both the buyer and the seller. In order to curb the proliferation of this anomaly, the paper concluded by advocating the clarity of intentions and activities as well as proper regulation and implementation of Islamic guidelines on salam on e-commerce, in line with Al-Ghazālī’s submission in his Iḥyā’u cUlūmi-d-Dīn.
An Examination of Jumia as a Business Entity Under Islamic Business Ethics
Authors: Suraju Saheed Badmus , Ayilara Rukayah  Yetunde
Published: December 2022

In the 21st century, online access has become widespread and inclusive to the point of making business easy for most people to survive in contemporary society. Series of online trading are available to raise money for people, including Muslims, without considering the business Ethics from Islamic Perspective while patronizing online trading. On this note, this paper examines the business operation of an online business entity from the point of view of Islamic business ethics with a view to using Jumia as a case study. The research findings show that there are non-Sharīa compliance operations in the online transaction of Jumia. It is also revealed that the Muslims patronizing Jumia business is not concerned about Islamic business ethics in their transaction. The paper concludes by advocating the application of Islamic business ethics in all transactions in which the Muslims will be involved in general and particularly in Jumia online services to give room for more Muslims to patronize the platform.
Oncogenic challenge of bromocriptine and L-arginine versus conventional antidiabetics on diethyl nitrosamine-induced liver tumorigenesis in diabetic rats: focus on AMPK activation
Authors: Hewedy Wafaa A. , Anwar Eman I. , Sharara Gehan M. , Hadi Mona A. , Darwish Suzan A. , Ismail Cherine A.
Published: December 2022

Background: Diabetes mellitus (DM) is associated with a spectrum of cancers where the metabolic antecedents, consequences, and therapy might affect cancer risk. The association between hepatocellular carcinoma (HCC) and DM had been confirmed. Approaches to HCC prevention focus on the molecular regulators of the disease process defined as the inflammation-fibrosis-cancer axis. The AMP-activated protein kinase (AMPK) is an interesting metabolic tumor suppressor and a promising target for cancer prevention and therapy. This study aimed to investigate the effects of bromocriptine mesylate and L-arginine on hepatic carcinogenesis on a rat model of hepatic neoplasia induced by diethyl nitrosamine (DENA) and promoted by type-2 DM in contrast to the conventional antidiabetics.Methods: One hundred male Wistar rats were randomly assigned into two sets; control set (normal, HCC, DM, and combined HCC/DM) and treated set where rats received one of the following drugs for another 5 weeks: insulin glargine, glimepiride, metformin, pioglitazone, bromocriptine mesylate, or L-arginine. Bodyweight changes, blood glucose level, liver functions tests, serum C-peptide and alpha-fetoprotein (AFP), and hepatic activated AMPK were assessed beside the hepatic histopathological changes.Results: Equivalent to metformin, bromocriptine and L-arginine treatment significantly reduced AFP, despite their minor glycemic control. L-arginine induced AMPK activation, yet less than metformin. Histopathologic examination revealed a reduction in hepatic intra-lobular chronic inflammatory cell infiltration, steatosis and necrosis by metformin, bromocriptine, and L-arginine. Hepatic necro-inflammatory changes were most prominent in insulin-treated rats.Conclusions: L-arginine and bromocriptine mesylate prevent early neoplastic changes almost equivalent to metformin at least partially via hepatic AMPK activation.
Evaluation of pharmacological prophylaxis for deep venous thrombosis in hospitalized patients with risk factors at the university teaching hospitals, Lusaka, Zambia
Authors: Kampamba Martin , Kafulu Davison , Hikaambo Christabel Nang’andu , Mudenda Steward , Hamachila Audrey , Hangoma Jimmy M.
Published: December 2022

Background: Deep venous thrombosis is a common clinical problem accounting for high rates of morbidity and mortality. The existence of risk factors, which include trauma, venous stasis, and hypercoagulability, is linked to the occurrence of the condition. Objective of current study was to evaluate DVT risk factors and prophylaxis pattern of use for patients who were admitted at the University Teaching Hospitals in Lusaka, Zambia.Methods: A cross-sectional study was conducted using medical files for patients who were hospitalized at the University Teaching Hospitals in Lusaka, Zambia from May 2020 to June 2021. Two hundred and ninety-six patient files were reviewed, and the Caprini risk assessment model was used to stratify patients into DVT risk categories. Multilinear regression analysis was used to identify factors associated with DVT prophylaxis.Results: Of the 296 patient files that were sampled from ICU, medical, and surgical wards, 198 (66.9%) (>2 caprini score) were eligible for DVT prophylaxis, but only 77 (38.9%) of these eligible patients received prophylaxis. The number of eligible patients for DVT prophylaxis per department was as follows; ICU 50 (100%), Medical 71 (57.7%) and Surgery 77 (62.6%) wards. However, DVT prophylaxis was given to 21 (42%), 33 (46.5%), and 23 (29.9%) patients from the ICU, medical, and surgery, respectively. Enoxaparin was the most commonly used anticoagulant for Venous thromboembolism (VTE) prophylaxis with a mean dose of 60mg (SD±5). Across all departments, the most common predisposing risk factors for DVT were bed confinement for >72 hours (167, 56.4%) and age of 41-60 years (118, 39.8%). In the adjusted model, swollen legs (AOR: 3.6, CI: 1.97, 6.57) and history of VTE (AOR: 21.3, CI: 9.87, 46.08) were significantly associated with a higher likelihood of DVT prophylaxis.Conclusions: Pharmacologic thromboprophylaxis is underutilized in patients in ICU, medical and surgical wards at the university teaching hospitals in Lusaka, Zambia. This study underscores the importance of implementing a DVT risk assessment technique for patients in ICU, medical and surgical wards and administering prophylaxis unless contraindicated.
Taxanes induced hypersensitivity reactions in cancer chemotherapy patients reported at adverse drug reaction monitoring centre at a tertiary care hospital
Authors: Begum Shaik Haseena , M. Venugopal Reddy , Sahayaraj Christina , S. Sharon Sonia , Y. Vijayabhaskara Reddy
Published: December 2022

Background: Cancer chemotherapy involves highly complex regimens using antineoplastic agents like taxanes (paclitaxel, docetaxel) etc. Taxanes cause hypersensitivity reactions (HSRs) like redness, rashes, dyspnoea, severe anaphylaxis and death. In this study, adverse drug reactions (ADRs) associated with taxanes are described & analysed on their severity and preventability. The present study aims to analyse and determine the prevalence of ADRs, especially HSRs in patients treated with taxanes.Methods: After getting IEC approval, the present study is done retrospectively by assessing the HSRs in suspected ADR reporting forms from December 2019 to February 2022 in ADR monitoring centre (AMC) in the Department of Pharmacology at Kurnool Medical College, Kurnool. Descriptive statistics used to analyse patient demography, frequency, various carcinomas under treatment & organ involved, causality assessment using WHO-UMC Scale and Naranjo's Algorithm, severity assessment using modified Hartwig & Siegel’s scale and preventability by modified Schumock & Thornton scale.Results: A total of 258 ADRs were recorded, of which 30 cases reported HSRs with taxanes-paclitaxel (22) and docetaxel (8). The most commonly occurred HSR is shortness of breath. Naranjo’s algorithm showed 52.5% possible (score 1-4) HSRs. WHO-UMC causality assessment scale showed 56.4% as probable HSRs. Modified Hartwig & Siegel severity scale showed 46.6% moderate (level 3). Modified Schumock and Thornton scale showed 76.9% as not preventable.Conclusions: Chemotherapy-related ADRs among cancer patients urges the oncologists to be actively involved in ADR reporting, in the need of the hour in order to mitigate, avoid their occurrence and reducing morbidity and mortality, when practiced with diligence.
A study of reporting pattern of adverse drug reactions in a tertiary care teaching hospital
Authors: Kumar Shailendra , Singh Rohit Kumar , Seth Raj Narayan , Sinha Rani Indira
Published: December 2022

Background: Adverse drug reactions (ADRs) are one of the prime causes of morbidity and mortality, increase in hospital stay and socioeconomic burden on the patients. Periodic monitoring aids in formulating methods for safe usage of medicines in hospitals. Identification of ADRs and their reporting pattern can provide useful information for their prevention. Hence this study was done to see the pattern of reported ADRs in Patna Medical College and Hospital, Patna in a 3 months of study.Methods: It was an observational and retrospective study carried out between July 2022 to September 2022. Both outpatients and inpatients were included in the study. The ADRs in the form of Individual Case Safety Reports (ICSRs) were sent to the nearby adverse drug reaction monitoring centre (AMC).Results: The occurrence of ADRs was more common in females (56.25%) as compared to males (43.75%). Patients of age-group 21-40 years (40.625%) were most commonly involved. Medicine department (34.375%) reported the maximum percentage of ADRs. Antimicrobials (37.50%) was the most common drug-group causing ADRs. Maximum reported ADRs (81.25%) were probable, 9.375% were possible, 6.25% were certain, while 3.125% were unlikely with the suspected drug as per Naranjo scale.Conclusions: The pattern of ADRs reported in our hospital is comparable with the results of studies conducted in hospital setup elsewhere, along with a few differences. The study results revealed opportunities for interventions in ADR management especially for the preventable ADRs to ensure safer drug use.
Knowledge, attitude and practicing behavior regarding antimicrobial use and awareness of antimicrobial resistance among interns and postgraduates in a tertiary care hospital
Authors: Nishat Samreen , Muhaimin Ali Mohammed Abdul , Butul Maleha , Sameen Samra , Siddiqua Syeda Ayesha
Published: December 2022

Background: Irrational use of antimicrobials and inaccurate practicing behavior leads to the issue of antibiotic resistance. This can be tackled by spreading awareness with the assistance of future medical practitioners. Hence, the present study was taken to determine the knowledge, attitude, and practicing behavior regarding antimicrobial use and awareness of antimicrobial resistance among interns and postgraduates.Methods: The study was conducted on interns and postgraduates in a tertiary care hospital. A standardized questionnaire was distributed to 120 participants and Ethical approval was taken before the study. Data was analyzed using SPSS software. For data comparisons, Chi-square tests were used, p≤0.05 is considered significant.Results: The study showed a majority in the 25 to 34 years of age group with female predominance. The subject of antibiotic resistance was moderately relevant to a majority, which highlighted a need for an increase in awareness workshops. The actual knowledge of respondents seems to be accurate in the study, a fair amount of attitude and practicing behavior was observed as well. A significant difference between the interns and postgraduates in knowledge (χ2=13.736, p=0.03), attitude (χ2=68.091, p=0.01), and practice (χ2=34.821, p=0.01) were noticed.Conclusions: Accurate knowledge and practicing behavior were observed in postgraduates and a fair attitude was observed in interns towards antimicrobial use and resistance. The awareness must be extended regarding this issue by conducting educational programs and by updating guidelines. Advancement in antibiotic prescribing pattern is required.
Pharmacovigilance of cutaneous adverse drug reactions-a focused research in times of COVID pandemic
Authors: Bag Ranit , Saha Debajyoti
Published: December 2022

Severe cutaneous adverse drug reactions are limiting, ranging from 5 cases per million including acute generalized exanthematous pustulosis (AGEP) and drug reaction with eosinophilia systemic symptoms (DRESS) to 1 case per million of toxic epidermal necrolysis. Cutaneous adverse drug reactions following drug therapy of COVID-19 are not uncommon. Viral infection and drug interactions predisposes to the development of cutaneous adverse drug reactions, as already documented with Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, and HIV. The Adverse drug reaction monitoring center of CNMCH has actively participated in pharmacovigilance programme of India by reporting few adverse drug reactions including the following cases. It is iterated that pharmacovigilance programme extends beyond just mere detection and reporting of adverse drug reactions and also should involve in assessment and understanding the cases, thus facilitating control and prevention of these cases. Particularly in times of COVID pandemic there has been continuous amendment in the treatment guidelines both at the central and state level. Incorporation of various antibiotics, antiparasites and antiviral drugs for the treatment of COVID, has potentiated the risk of development of drug allergies. Admittedly, the detailed understanding of drug allergy cases has been in general constrained with a relative lack of access to standardized laboratory diagnostic tests. Focused research is the need of the hour in order to understand the drug allergies better. In this study we have included those cases reported by department of medicine and dermatology of Calcutta national medical college and hospital in the past six months. All the cases were COVID positive and were treated conservatively by de-challenging the culprit drug and administration of antihistamines, topical steroids, while a few was put on systemic steroid therapy. There were six such reported cases of cutaneous adverse drug reaction following COVID treatment. There were four cases of maculopapular drug eruptions, while the other cases were diagnosed with fixed drug eruptions and acute generalized exanthematous pustulosis respectively. All the cases were reported under pharmacovigilance programme of India.
COVID-19 vaccine induced Guillain-Barre syndrome: a case report
Authors: Shamim M. , Nawaz Ghulam , Sinha Rani Indira
Published: December 2022

Guillain-Barre syndrome (GBS) is a rare immune mediated clinical disorder of the peripheral nerves. A number of vaccines including COVID-19 vaccine have been shown to be associated with an increased risk of GBS. We reported a case of Corbevax® (COVID-19 vaccine) induced GBS. A 12 years old girl presented to the paediatric emergency with 2 days history of progressive weakness of all four limbs. The weakness started after one day of patient received her first dose of Corbevax®. Neurological examination findings were weakness, decreased muscles tone, decreased muscles power, diminished or absent deep tendon reflexes of all four limbs. The findings of cerebrospinal fluid showed increase in protein and normal cell count. The diagnosis of GBS was confirmed by nerve conduction studies. After confirmation of the diagnosis, she was given intravenous immunoglobulin (IVIG) with the dose of 2 g/kg body weight divided over 5 consecutive days. Then the patient was examined, clinical condition was improved dramatically. GBS rarely caused by COVID-19 vaccination. GBS may become life threatening due to respiratory muscles involvement. In about 30% of cases may require admission in Intensive Care Unit and need for mechanical ventilatory support. So careful monitoring is required after administration of COVID-19 vaccine. This case report never discourages the vaccine rollout, but monitoring of evolving data should be carried on by manufacturers and independent authorities coming to a definite conclusion.
Animal models of anxiety: a review
Authors: Desingu Ramyaa , Sadasivam Balakrishnan , Kalra Shamsher Singh , Lakhawat Bhawna
Published: December 2022

Anxiety is a disorder that affects the quality of life and also imposes a huge economic burden. Animal models of anxiety have widened our understanding of the pathophysiology behind anxiety and to identify newer pharmacological compounds. Every behavioral test has its own limitations, and there are ways to minimize these like environment and handling. This review lists various experimental models of anxiety based on unlearned ethological models, learned responses like the Vogel conflict test, and psychological and physical stress models.
Factors affecting the adoption of modern fish farming technologies in Gokwe South District, Zimbabwe
Authors: Dube Stellah , Mabika Nyasha
Published: December 2022

Background: Fish are a source of cheap protein to many rural communities in Zimbabwe. Unfortunately, very few fish farmers are not willing to adopt modern fish farming technologies in order to boost fish production. The study was carried out in order to establish the factors that are affecting fish farmers in adopting the modern fish farming technologies in Gokwe South District, Zimbabwe.
Methods: A household survey using a structured questionnaire was administered in February 2022.
Results: Sixty-four respondents participated in the survey and the majority (73%) were males. Most (47%) of the fish farmers were above 46 years. The common source of fish farming information was through non-governmental organizations (NGO) (40%) and through government departments (27%). The challenges affecting fish farmers in the area included financial constraints (40%), absence of markets (26%), lack of fishing equipment in local shops (13%) and the absence of fishing inputs and equipment in local shops (13%). Water shortage was the major (27%) factor affecting the adoption of modern technologies and this was followed by financial constraints (20%), political interference (20%), traditional and cultural beliefs (13%) and lack of knowledge (7%).
Conclusions: Modern fish farming technologies need to be fully embraced to raise both food and nutrition security particularly in rural communities. This can be achieved by the involvement of the government, traditional leaders, NGO and other stake holders in the provision of funds, training, monitoring and implementing of fishery projects in the area.
Case report of pyoderma gangrenosum in association with orthopaedic trauma
Authors: Jajoria Hina , Jayan Jeeno
Published: December 2022

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis characterized by painful skin ulcers. It is associated with various systemic diseases but is rarely associated with orthopedic conditions. We report a case of a pyogenic gangrenosum in a 40-year-old male, that occurred in association with a lower limb fracture. This patient suffered a laceration over the ankle which was the sutured initially and the fracture was managed conservatively. Later on the wound was complicated with the development of pyoderma gangrenosum. Failure to treat with antibiotics and local wound management lead to alternative diagnosis by dermatologist. Patient was successfully managed by dermatologist and fracture was managed conservatively. Such incidents of PG in association with orthopedic procedures, complicate treatment and cause delay in recovery, leading to poor patient outcome.
ОЦІНКА ЯКОСТІ ВИРОБІВ З КОМПОЗИЦІЙНИХ МАТЕРІАЛІВ ЗА ХАРАКТЕРИСТИКАМИ МІЦНОСТІ
Authors: Мікосянчик  Оксана , Литвиненко Валентин , Жосан Олександр , Педан  Євген
Published: December 2022

Проведена оцінка методів, направлених на забезпечення високої якості та прогнозування властивостей виробів з композиційних матеріалів на етапі виробництва. Розглянуто шляхи удосконалення процесу оцінки якості виробів з композиційних матеріалів на етапі вибору оптимальної технології їх виготовлення. Проаналізовані ключові параметри технологічного процесу виготовлення виробів з композиційних матеріалів з застосуванням схеми причинно-наслідкових зв'язків та побудована діаграма Ісікави для визначення причин появи виробничих дефектів композитів. Проведена оцінка впливу кута укладання шарів однонаправленої вуглецевої тканини на міцність перехресно-армованого композиційного матеріалу.
OPTIMAL CHARACTER AND DIFFERENT NATURE OF FLOWS IN LAMINAR BOUNDARY LAYERS OF INCOMPRESSIBLE FLUID FLOW
Authors: Lukianov  Pavlo , SONG Lin
Published: December 2022

The paper presents an original approach to the study of the problem of internal friction arising from the motion of a rigid body in an incompressible fluid. This approach takes into account the spatial variability of molecular viscosity in the boundary layer region, and the solution of the problem is based on the use of an extreme for the fluid flow rate functional. The spatial variability of molecular viscosity in the boundary layer, by a well-known analogy with the theory of heat conduction, is based on the absence of a spatial isotropy of the medium. It is shown that molecular viscosity depends on the nature of the flow - on how many forces act on the fluid. So, if the flow is unsteady and non-gradient or steady and gradient, then both of these flows are subject to the action of two forces. In such flows, the molecular viscosity due to the extreme of the fluid flow rate is a constant value. It has been fond that the distribution of velocity in a gradient stationary boundary layer has a parabolic distribution law, and all existing theories are described by this law quite accurately, with an error of maximum 5%. At the same time, in a laminar non-gradient boundary layer, only the force of internal friction acts on the fluid. This causes the spatial variability of molecular viscosity: shear stress can be constant not only due to the linearity of the velocity distribution, which is not observed in the boundary layer, but also due to the variability of molecular viscosity. The resulting exponential velocity distribution in a non-gradient boundary layer is in complete agreement with those in the problems solved by Stokes, and is also confirmed experimentally. The paper also points out that the exponential law is consistent with modern data obtained by direct numerical simulation (DNS) for flows with Low Reynolds numbers – both single-phase and two-phase, in the presence of particles inside the fluid.
THE PRELIMINARY PROJECT OF THE RIVER TOW VESSEL POWERED BY A PYROLYSIS GAS GENERATOR POWER PLANT
Authors: Obodovskyi  Ivan , Morozov Viacheslav
Published: December 2022

The article is dedicated to the one of many options of a practical application of the pyrolysis gas generator, which is its installation on the typical river-class tow vessel. The essence of the idea is the installation of the pyrolysis gas power plant that includes gas generator, gas filtering system, power plant and electric engines that would drive the vessel. The gas generator of the inverted type is able to create flammable gas out of either wood, or charcoal, or so-called RDF (the RDF should be taken of specific proportion of its ingredients, corresponding to the ecologic laws of the operator’s country), thus, allowing the vessel to be powered by typical industrial and household wastes, delivered from all the city.  Since such types of ships are mostly used within the range of a city and more often even within ports only, the fuel for the vessel would always be available in sufficient volumes. The vessel itself should be able to reach the necessary velocity (taking into a count the flow velocity of the river) and also be able to push the certain barge or another vessel in order to do some practical tasks. This vessel will be independent from fossil fuels and it could be powered even by wood chops, collected in any forest near the river or by a big pack of charcoal, purchased in the supermarket. The presented calculations show some possible technical solutions for the given task, taking into a count the lowest possible price and availability of components. However, there is no limit in pyrolysis technology improvement and the project of this vessel can be improved as well depending on the available funding.
Високоефективна рідинна хроматографія як перспективний метод для визначення хлорамбену
Authors: Мага І.М.
Published: December 2022

Проведено дериватизацію хлорабену 4-нітрофенілдиазанієм. Досліждено екстракцію азодеривату різними екстрагентами, Вивчено умови хроматографування: склад рухомої фази, співвідношення компонентів, швидкість подачі елюента, хроматографічні параметри. Розроблена методика визначення хлорамбену методом ВЕРХ, встановлено межі лінійної залежності площі піку від концентрації хлорамбену. Методика апробована на модельних розчинах.
Аналіз біобезпеки пасажирських перевезень авіаційним транспортом
Authors: Декар Д.О. , Горупа В.В.
Published: December 2022

Розглянуто проблему поширення патогенних мікроорганізмів на борту пасажирського літака. Доведено, що система кондиціонування повітря повітряного судна та організація повітряних потоків в салоні є основними чинниками в інфікуванні пасажирів під час перельоту. Представлені та обґрунтовані рекомендації зміни напряму руху повітряних потоків для унеможливлення інфікування пасажирів під час перельоту.
Quantitative determination of tannin content in medicinal plants
Authors: Kuznietsova Olena
Published: December 2022

The group of tannins includes substances of plant origin, which are complex organic compounds that are derivatives of polyatomic phenols with a variety of chemical structures. There are a lot of methods for quantitative determination of tannins content such as gravitometric methods, permanganatometric titration, spectrophotometric and high performance liquid chromatography methods. In the work, the comparative analysis of these methods was carried out.
Toward the technology of large cranberry fruit storage through declining the fungal rots
Authors: Andrianova Tetiana , Konovalchuk Valeriy
Published: December 2022

Study of fungal invasions and storage rots of cultivated large cranberry on experimental plots of commercial plantations in Rivno and Volyn’ oblasts during 2019–2020 are presented. Berries of the cultivar Wilcox, as more commercially promising, were selected for the final step of investigations. Losses of harvest were recorded during berries storage as a result of the pathogenic fungi infections and on the final step of study the plant material received post-harvest treatment by cold and hot water in different variants, with subsequent drying by warm air. There were examined storage results of the fruits collected in autumn and in early winter, percentage of different types of fungal rots development were estimated.
Пiдвищення стiйкостi пшеницi ярої сорту Печерянка до збудника базального бактерiозу за дiї нiтропрусциду натрiю
Authors: Буценко Людмила Миколаївна
Published: December 2022

Дослiди з вивчення впливу нiтропрусциду натрiю на стiйкiсть пшеницi до збудника базального бактерiозу проводили на тижневих паростках пшеницi ярої (Triticum aestivum L.) сорту Печерянка у квiтнi 2021 року.
Застосування сучасних методик при викладаннi дисциплiни «Генетика тварин»
Authors: Супрун Ірина Олександрівна
Published: December 2022

При викладаннi дисциплiни “Генетика тварин” студентам на рiзних її етапах використовуються такi елементи, як комп’ютернi технологiї та електронний навчальний курсу для самостiйної роботи, демонстрацiя анiмацiйних фрагментiв, використання презентацiй та опорного конспекту при поясненнi, тестовий контроль з метою виявлення рiвня засвоєння знань на заняттi.
Ацилгомосеринлактони — новiтнi регулятори стресостiйкостi i врожайностi аграрних культур
Authors: Бабенко Лідія Михайлівна , Косакiвська Iрина Василівна , Войтенко Леся Василівна , Романенко Катерина Олександрівна
Published: December 2022

Ацилгомосеринлактони (АГЛ) — клас молекул-медiаторiв бактерiального походження, задiяних у дистанцiйнiй трансдукцiї сигналiв мiж бактерiями-колонiзаторами фiтосфери, а також мiж бактерiями i рослиною.
Бiотехнологiчний бета-каротин, оцiнка токсичностi та безпечностi
Authors: Дмитруха Наталія Миколаївна , Лагутiна Ольга Сергіївна , Короленко Тамара Костянтинівна
Published: December 2022

Проведено дослiдження токсикологiчних властивостей бiотехнологiчного препарату β-каротину на органiзм щурiв Вiстар в умовах субхронiчного експерименту. Отриманi данi вказують на iмуностимулюючу, мембрано- та гепатопродекторну дiї дослiджуваного препарату.
RAPD-ДНК аналiз як iнструмент для бiомониторингу популяцiї азовського калкану
Authors: Дячков Михайло Вікторович , Дем’яненко Костянтин Володимирович
Published: December 2022

Було проаналiзовано генетичну мiнливiсть азовського калкану (Scophthalmus maeotica torosa) з рiзних дiлянок Азовського моря за допомогою RAPD-ДНК аналiзу фрагментiв плавцiв.
Використання вiдходiв кави у бiотехнологiї
Authors: Чуба Святослав В’ячеславович
Published: December 2022

Розглянуто переробку вторинних продуктів і відходів, що залишаються після виробництва кави, за допомогою біотехнологічних методів.
Маркетингове обґрунтування доцільності розробки нових вітчизняних засобів для лікування акне
Authors: Шаблій Любов Матвіївна
Published: December 2022

Акне є поширеним хронічним запальним захворюванням шкіри, яке різко знижує якість життя хворих, може призвести до появи косметичних дефектів та розладів психоемоційної сфери.

Метою роботи було проведення маркетингового дослідження українського фармацевтичного ринку дерматологічних лікарських засобів для фармакотерапії акне.

Для дослідження було взято офіційні джерела інформації про зареєстровані в Україні лікарські засоби.

Встановлено, що повний асортимент дерматологічних лікарських засобів становить 587 торгових найменувань. Група D10 «Препарати для лікування акне» складається з 23 торгових назв, з яких 17 місцевих засобів (D10A) та 6 засобів для системного лікування (D10B).

Визначено, що 76,5% групи D10A та 100% групи D10В є препаратами зарубіжного виробництва.
Вплив низькочастотних полів на процес очищення дріжджовмісних стічних вод
Authors: Поштаренко Анна Віталіївна , Решетняк Людмила Расулівна
Published: December 2022

Дослідження було спрямоване на вивчення дії низькочастотного випромінювання на кількість мікроорганізмів, підбір оптимального режиму (поєднання залежності напруги та експозиції) обробки стічної дріжджовмісної води з метою досягнення найбільшої ефективності. Вивчаючи дані досліджень виявлена​​ закономірність: збільшення напруги і експозиції низькочастотного впливу на дріжджовмісні стічні води призводить до зменшення показника загального мікробного числа.
Cytogenetic monitoring of freshwater aquaculture in Ukraine
Authors: Glushko Yuliia , Mruk Antonina , Bielikova Olena , Kozubska-Sobocinska Anna
Published: December 2022

The results of cytogenetic analysis of freshwater aquaculture in Ukraine are presented.
Використання поліфенольних сполук бузини чорної при виробництві соковмісних напоїв
Authors: Токаренко С.А. , Романов О.С. , Романова Зоряна Миколаївна , Косоголова Людмила Олексіївна
Published: December 2022

Харчова цінність дикорослої рослинної сировини визначається вмістом поживних речовин: вітамінів, мінералів та інших важливих компонентів, які відіграють важливу роль у харчуванні людини, регулюють обмінні процеси, впливають на функції окремих органів. Важливо зберегти їх для виробництва функціональних напоїв.
Використання вторинних продуктiв переробки яблук при виробництвi хлiба з обойного борошна
Authors: Веселовська Таїсія Євгеніївна
Published: December 2022

У роботі запропоновано та обгрунтовано доцільність використання вторинних продуктiв переробки яблук при виробництвi хлiба з обойного борошна.
Еритроцити — унiкальна модель адаптацiйних можливостей органiзму
Authors: Гаркава Катерина Григорівна
Published: December 2022

Особлива структура еритроцитів та стан їх мембран у людини дає змогу судити про адаптаційні можливості організму.
Analysis of yeast conservative nucleotide sequences by genomic bioinformatic methods
Authors: Yarmolenko Marianna , Zelena Lyubov , Hretsky Igor , Tkachuk Nataliia
Published: December 2022

The purpose of the present study was the bioinformatic analysis of conservative nucleotide sequences, their variability between different yeast species and genus. The results obtained in the study can facilitate the selection of yeast phylogenetic biomarkers and promote the establishment of yeast sequences database.
ВПЛИВ ДІЯЛЬНОСТІ МІЖНАРОДНИХ ФІНАНСОВИХ ОРГАНІЗАЦІЙ НА РОЗВИТОК НАЦІОНАЛЬНИХ ПРАВОВИХ СИСТЕМ
Authors: Кузьмін Андрій
Published: December 2022

Мета: полягає в аналізі ролі впливу міжнародних фінансових організацій на правові системи різних країн, державну політику в різних сферах суспільного життя, дослідженні нормативно-правової бази країн, що регулює взаємовідносини при співробітництві з Міжнародними фінансовими організаціями. Методи дослідження: становить широкий спектр філософсько-світоглядних, загальнонаукових та спеціально-наукових методів і підходів, що сприяло вирішенню основних завдань дослідження, особливо подальшому виявленню з позиції специфіки правового регулювання діяльності Міжнародних фінансових організацій в різних країнах та висвітленню форм їхньої діяльності в еволюційному розвитку міжнародних валютних відносин. Застосування описового методу дозволило охарактеризувати міжнародні фінансові організації. За допомогою формально-юридичного методу було проаналізовано співробітництво країн з міжнародними фінансовими організаціями. Метод аналізу застосовувався для дослідження сучасного стану співпраці країн з міжнародними фінансовими організаціями. Результати: зроблено висновок, що співробітництво різних країн з міжнародними фінансовими організаціями, прямо впливає на реалізацію одного з основних принципів міжнародного права – незалежності. Залучаючи іноземний капітал в бюджет, країни стають повністю залежними від волі кредиторів, які в свою чергу діють виключно в своїх інтересах. І хоча в деяких сферах економічного життя країни може прослідковуватись певний прогрес, існує необхідність жорсткого правового регулювання діяльності міжнародних фінансових організації в країні. Обговорення: пошук та розроблення шляхів подолання наявних проблем у співробітництві країн з міжнародними фінансовими організаціями, а також дослідження норм, шо регулюють такі відносини, задля успішної імплементації їх у національне законодавство України.
ПРОБЛЕМИ ВИЗНАЧЕННЯ ПРАВОВОГО РЕЖИМУ ДОМЕННИХ ІМЕН
Authors: Цибізова Стелла
Published: December 2022

Метою даної статті є винайдення підходів щодо визначення правового режиму нетипових об’єктів цивільного права, зокрема, доменних імен. Для цього необхідно проаналізувати рівень загальнотеоретичної розробки дефініції «правового режиму» в науці права, існуючі позиції щодо поняття правового режиму об’єктів цивільного права. Після чого визначити ознаки нетипових об’єктів цивільного права та, враховуючи специфіку їх, визначити оптимальні підходи щодо моделювання правового режиму останніх. Методологічною основою дослідження є загальнонаукові та спеціальні методи пізнання. Використання цих методів дало можливість описати проблеми визначення правового режиму доменних імен. Результати: цивільно-правовий режим доменних імен обумовлюється їх правовою природою та пропонується визначити, як сукупність властивостей та об’єктивно притаманних ознак даного нетипового об’єкта, з якими норми права пов’язують певні правові наслідки. Обговорення: застосування до нових об’єктів цивільних прав, існуючих підходів щодо визначення правового режиму об’єктів цивільних прав є проблематичним, оскільки такі об’єкти є нетиповими та потребують винайдення нових принципів моделювання правового режиму.
ДІЯЛЬНІСТЬ ЮРИДИЧНИХ КЛІНІК В УМОВАХ ВОЄННОГО СТАНУ
Authors: Богатюк Ірина
Published: December 2022

Мета: дослідити особливості діяльності юридичних клінік в умовах воєнного стану. Методи дослідження: пізнавально-аналітичний, порівняльно-правовий аналіз, об’єктивної істини та ін. Дані методи дають можливість прослідкувати динаміку створення юридичних клінік, їх види, специфіку діяльності на сучасному етапі під час дії воєнного стану. Результати: проаналізовані особливості становлення юридичних клінік у світі та Україні, виокремлена діяльність Юридичної консультації «Юридична клініка» Національного авіаційного університету (НАУ) в системі клінічної діяльності, підкреслена важливість медіаційної та інформаційно-культурної діяльності юридичної клініки за участі студентів та викладачів-консультантів, зосереджена увага на значенні клінічної освіти для становлення майбутніх фахівців у сфері права. Обговорення: відзначено, що в Україні є велика кількість внутрішньо переміщених осіб унаслідок військового вторгнення, які потребують юридичної допомоги в питанні отримання статусу ВПО, фіксування завданих збитків внаслідок втрати майна, надання допомоги людям з обмеженими можливостями, пенсіонерам, іншим вразливим категоріям громадян України. Окремої уваги заслуговують питання та роз’яснення щодо перетину державного кордону в умовах дії воєнного стану та перебування в країнах ЄС на умовах біженства чи тимчасового статусу.

Автор відзначила, що існує гостра потреба у роз’ясненнях щодо укладення, зміни та розірвання трудового договору в умовах воєнного стану. Відповідно, юридичні клініки, які надають правовому допомогу в період військових викликів щодо вказаних категорій осіб, здійснюють надзвичайно важливу роботу для людей, держави і суспільства.
ІНФОРМАЦІЙНА ВІЙНА ПРОТИ УКРАЇНИ ТА ПРАВОВІ ЗАСОБИ ПРОТИДІЇ ЗЛОЧИННИМ ДІЯМ
Authors: Сопілко Ірина
Published: December 2022

Мета: дослідити особливості та сутність інформаційної війни та надати рекомендації з приводу правового регулювання відповідних питань в Україні. Методи дослідження: дана наукова стаття була написана автором із залученням загальновизнаних методів наукового пізнання, а саме, аналітичного, формального, порівняльно-правового, системно-структурного та інших. Результати: досліджено поняття, суть, характеристики інформаційної війни та пов’язаних із нею категорій, вказано на проблеми забезпечення протидії зловимсним діям у цій сфері, надано пропозиції щодо подолання таких проблем шляхом вдосконалення чинного законодавства, в тому числі, за рахунок досвіду інших країн та гармонізації діючої нормативно-правової бази із стандартами Євросоюзу. Обговорення: дискусія у науковому дослідженні ведеться щодо особливостей правового врегулювання загроз та ризиків, з якими стикається Україна під час гібридної та безпосередньо інформаційної війни, що ведеться проти неї.
Unrecognized Saint Procopius Ustyansky and new information about the creative biography of Semyon Shakhovsky
Authors:   Bunin Yelets State University, Lyapin Denis A.
Published: December 2022

The articlecompares two works of the 17thcentury: the poetic prayer of Prince S. I. Shakhovsky, dedicated to St. Demetrius of Vologda, and the prayer to the locally venerated Vologda ascetic Procopius Ustyansky, which was not recognized by the official church. These texts are almost identical. The author proves that the first was a poem by Shakhovsky, and it became the basis forcreating a prayer to Procopius Ustyansky. This conclusion allows us to obtain new information about the creative biography of Shakhovsky, which are associated with problems with the authorities in the 1620s.
V. A. Perovsky’s campaign to the Ak Mosque in 1853
Authors:   Bashkir State University, Maryutkin Vitaly V.
Published: December 2022

This article focuses on the military expedition of Orenburg and Samara Governor-General V. A. Perovsky against important Kokand fortress AK-Mosque that stood by the river Syrdarya in 1853, which resulted in the capture of the Kokand fortresses and the stabilization of the situation in the Central Asian caravan routes in the middle of the XIX century. The article also presents the causes and preconditions of operation, determined by the historical significance of this campaign, which became part of the prehistory of the large-scale seizure of Central Asia by the Russian Empire in the second half of the XIX century, based, among other things, on unpublished archival sources.