bluuebunny/crossref_metadata_2025 huggingface dataset:
Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial
Authors: Daly Aideen B. , Boughton Charlotte K. , Nwokolo Munachiso , Hartnell Sara , Wilinska Malgorzata E. , Cezar Alina , Evans Mark L. , Hovorka Roman
Published: January 2023

In adults with type 2 diabetes, the benefits of fully closed-loop insulin delivery, which does not require meal bolusing, are unclear. In an open-label, single-center, randomized crossover study, 26 adults with type 2 diabetes (7 women and 19 men; (mean ± s.d.) age, 59 ± 11 years; baseline glycated hemoglobin (HbA1c), 75 ± 15 mmol mol−1 (9.0% ± 1.4%)) underwent two 8-week periods to compare the CamAPS HX fully closed-loop app with standard insulin therapy and a masked glucose sensor (control) in random order, with a 2-week to 4-week washout between periods. The primary endpoint was proportion of time in target glucose range (3.9–10.0 mmol l−1). Analysis was by intention to treat. Thirty participants were recruited between 16 December 2020 and 24 November 2021, of whom 28 were randomized to two groups (14 to closed-loop therapy first and 14 to control therapy first). Proportion of time in target glucose range (mean ± s.d.) was 66.3% ± 14.9% with closed-loop therapy versus 32.3% ± 24.7% with control therapy (mean difference, 35.3 percentage points; 95% confidence interval (CI), 28.0–42.6 percentage points; P < 0.001). Time > 10.0 mmol l−1 was 33.2% ± 14.8% with closed-loop therapy versus 67.0% ± 25.2% with control therapy (mean difference, −35.2 percentage points; 95% CI, −42.8 to −27.5 percentage points; P < 0.001). Mean glucose was lower during the closed-loop therapy period than during the control therapy period (9.2 ± 1.2 mmol l−1 versus 12.6 ± 3.0 mmol l−1, respectively; mean difference, −3.6 mmol l−1; 95% CI, −4.6 to −2.5 mmol l−1; P < 0.001). HbA1c was lower following closed-loop therapy (57 ± 9 mmol mol−1 (7.3% ± 0.8%)) than following control therapy (72 ± 13 mmol mol−1 (8.7% ± 1.2%); mean difference, −15 mmol mol−1; 95% CI, −11 to −20 mmol l−1 (mean difference, −1.4%; 95% CI, −1.0 to −1.8%); P < 0.001). Time < 3.9 mmol l−1 was similar between treatments (a median of 0.44% (interquartile range, 0.19–0.81%) during the closed-loop therapy period versus a median of 0.08% (interquartile range, 0.00–1.05%) during the control therapy period; P = 0.43). No severe hypoglycemia events occurred in either period. One treatment-related serious adverse event occurred during the closed-loop therapy period. Fully closed-loop insulin delivery improved glucose control without increasing hypoglycemia compared with standard insulin therapy and may represent a safe and efficacious method to improve outcomes in adults with type 2 diabetes. This study is registered with ClinicalTrials.gov (NCT04701424).
Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers
Authors: Zhong Charlie , Wang Rong , Morimoto Libby M. , Longcore Travis , Franklin Meredith , Rogne Tormod , Metayer Catherine , Wiemels Joseph L. , Ma Xiaomei
Published: January 2023

Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children (age 0–14 years); however, the etiology remains incompletely understood. Several environmental exposures have been linked to risk of childhood ALL, including air pollution. Closely related to air pollution and human development is artificial light at night (ALAN), which is believed to disrupt circadian rhythm and impact health. We sought to evaluate outdoor ALAN and air pollution on risk of childhood ALL. The California Linkage Study of Early-Onset Cancers is a large population-based case–control in California that identifies and links cancer diagnoses from the California Cancer Registry to birth records. For each case, 50 controls with the same year of birth were obtained from birth records. A total of 2,782 ALL cases and 139,100 controls were identified during 2000–2015. ALAN was assessed with the New World Atlas of Artificial Night Sky Brightness and air pollution with an ensemble-based air pollution model of particulate matter smaller than 2.5 microns (PM2.5). After adjusting for known and suspected risk factors, the highest tertile of ALAN was associated with an increased risk of ALL in Hispanic children (odds ratio [OR] = 1.15, 95% confidence interval [CI] 1.01–1.32). There also appeared to be a borderline association between PM2.5 level and risk of ALL among non-Hispanic White children (OR per 10 µg/m3 = 1.24, 95% CI 0.98–1.56). We observed elevated risk of ALL in Hispanic children residing in areas of greater ALAN. Further work is needed to understand the role of ALAN and air pollution in the etiology of childhood ALL in different racial/ethnic groups.
Lifespan changes in postural control
Authors: Van Humbeeck Nathan , Kliegl Reinhold , Krampe Ralf T.
Published: January 2023

Lifespan development of postural control shows as an inverted U-shaped function with optimal performance in young adults and similar levels of underperformance in children and older adults. However, similarities in children and older adults might conceal differences in underlying control processes. We mapped out age-related differences in postural control using center-of-pressure trajectories of 299 participants ranging from 7 to 81 years old in three tasks: stable stance, compromised vision, and narrowed base of support. Summary statistics (path length, ellipse area) replicated the well-known U-shape function also showing that compromising vision and narrowing the base of support affected older adults more than children. Stabilogram diffusion analysis (SDA) allows to assess postural control performance in terms of diffusion at short (< 1 s) and longer timescales. SDA parameters showed the strongest short-term drift in older adults, especially under compromised vision or narrowed base of support conditions. However, older adults accommodated their poor short-term control by corrective adjustments as reflected in long-term diffusion under eyes closed conditions and initiating anti-persistent behavior earlier compared with children and young adults in tandem stance. We argue that these results highlight the adaptability of the postural control system and warrant a reinterpretation of previous postural control frameworks.
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10
Authors: Ivaldo Caterina , Passalacqua Mario , Furfaro Anna Lisa , d’Abramo Cristina , Ruiz Santiago , Chatterjee Prodyot K. , Metz Christine N. , Nitti Mariapaola , Marambaud Philippe
Published: January 2023

Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) integrity and vascular homeostasis. Here, we show that oxidative stress triggered by H2O2exposure induced efficient VE-cadherin proteolysis by MMPs and γ-secretase in human umbilical endothelial cells (HUVECs). The cytoplasmic domain of VE-cadherin produced by γ-secretase, VE-Cad/CTF2—a fragment that has eluded identification so far—could readily be detected after H2O2treatment. VE-Cad/CTF2, released into the cytosol, was tightly regulated by proteasomal degradation and was sequentially produced from an ADAM10/17-generated C-terminal fragment, VE-Cad/CTF1. Interestingly, BMP9 and BMP10, two circulating ligands critically involved in vascular maintenance, significantly reduced VE-Cad/CTF2 levels during H2O2challenge, as well as mitigated H2O2-mediated actin cytoskeleton disassembly during VE-cadherin processing. Notably, BMP9/10 pretreatments efficiently reduced apoptosis induced by H2O2, favoring endothelial cell recovery. Thus, oxidative stress is a trigger of MMP- and γ-secretase-mediated endoproteolysis of VE-cadherin and AJ disassembly from the cytoskeleton in ECs, a mechanism that is negatively controlled by the EC quiescence factors, BMP9 and BMP10.
Awareness and use of HIV pre-exposure prophylaxis and factors associated with awareness among MSM in Beijing, China
Authors: Sun Yanming , Lu Hongyan , Ye Jingrong , Li Dongmin , Li Guiying
Published: January 2023

Human immunodeficiency virus (HIV) sexual transmission among men who have sex with men (MSM) has increased markedly in Beijing, China in the past decade. Pre-exposure prophylaxis (PrEP) is a highly efficacious biomedical prevention strategy that remarkably reduces HIV-transmission risk. This study examined PrEP awareness among MSM and the factors influencing it. From April to July 2021, respondent-driven sampling was used to conduct a cross-sectional survey among MSM in Beijing, China. Demographic, behavior, and awareness data regarding PrEP were collected. The factors influencing PrEP awareness were assessed using univariate and multivariable logistic regression. In total, 608 eligible responders were included in the study. Among the respondents, 27.9% had PrEP awareness, 3.3% had taken PrEP, and 57.9% expressed interest in receiving PrEP, if required. Greater odds of PrEP awareness were associated with higher education level (adjusted odds ratio [aOR] 3.525, 95% confidence interval [CI] 2.013–6.173, P < 0.0001), greater HIV-related knowledge (aOR 3.605, 95% CI 2.229–5.829, P < 0.0001), HIV testing (aOR 2.647, 95% CI 1.463–4.788, P = 0.0013), and sexually transmitted infections (aOR 2.064, 95% CI 1.189–3.584, P = 0.0101). Lower odds of PrEP awareness were associated with higher stigma score (aOR 0.729, 95% CI 0.591–0.897, P = 0.0029). The findings indicate sub-optimal awareness and low utilization of PrEP in Beijing and highlight PrEP inequities among MSM with stigma. Strengthening the training of peer educators in disseminating PrEP knowledge and reducing stigma are critical for improving PrEP awareness.
Space-resolved chemical information from infrared extinction spectra
Authors: Thuiya Hennadige Yushmantha Ishan Kalpa de Silva , Akbar Proity Nayeeb , Blümel Reinhold
Published: January 2023

A new method is presented for the extraction of the complex index of refraction from the extinction efficiency, $$Q_{ext} {({\tilde{\nu }})}$$

Q

ext

(

ν
~

)

, of homogeneous and layered dielectric spheres that simultaneously removes scattering effects and corrects measured extinction spectra for systematic experimental errors such as baseline shifts, tilts, curvature, and scaling. No reference spectrum is required and fit functions may be used that automatically satisfy the Kramers–Kronig relations. Thus, the method yields the complex refractive index of a sample for unambiguous interpretation of the chemical information of the sample. In the case of homogeneous spheres, the method also determines the radius of the sphere. In the case of layered spheres, the method determines the substances within each layer. Only a single-element detector is required. Using numerically computed $$Q_{ext}({\tilde{\nu }})$$

Q

ext

(

ν
~

)

data of polymethyl-methacrylate and polystyrene homogeneous and layered spheres, we show that the new reconstruction algorithm is accurate and reliable. Reconstructing the complex refractive index from a published, experimentally measured raw absorbance spectrum shows that the new method simultaneously corrects spectra for scattering effects and, given shape information, corrects raw spectra for systematic errors that result in spectral distortions such as baseline shifts, tilts, curvature, and scaling.
Construction of superhydrophobic graphene-based coating on steel substrate and its ultraviolet durability and corrosion resistance properties
Authors: Mohamed M. E. , Mekhaiel P. S. , Mahgoub F. M.
Published: January 2023

For the first time, a facile and environmentally friendly approach for producing high-quality graphene from the biomass of banana leaves is described in this paper. Two rough coats of Ni-graphene, Ni@G, and Ni-graphene doped with chromium, Ni@Cr-G, were created on steel substrates by electrostatic deposition. These coatings were then submerged in an ethanolic solution of myristic acid, MA, to produce a superhydrophobic, SHP, surface. The Raman spectra demonstrated that the generated graphene was of high quality. Fourier transform infrared spectroscopy findings confirm the modification of the Ni@G coating by MA, Ni@G@MA, and the modification of the Ni@Cr-G composite with MA, Ni@Cr-G@MA. The results of the scanning electron microscope revealed that the created SHP coatings have nanoscale features. The wettability results showed that the water contact angle values for Ni@G@MA and Ni@Cr-G@MA coatings are 158° and 168°, while the water sliding angle values for both coatings are 4.0oand 1.0°, respectively. The atomic force microscopy results show that both Ni@G and Ni@Cr-G coatings increase the roughness of the steel. The chemical and mechanical stability of the Ni@Cr-G@MA coating was higher than those of the Ni@G@MA coating. The coated steel by Ni@Cr-G@MA exhibits UV stability up to 110 h, while the SHP-coated steel by Ni@G@MA exhibits UV stability for 60 h. The potentiodynamic polarization results show that the value of the corrosion current density for bare steel is 13 times that of steel coated with Ni@G@MA, and 21 times that of coated steel with Ni@Cr-G@MA. The electrochemical impedance spectroscopy, EIS, results show that the charge transfer resistance for steel coated with Ni@G@MA is 38 times that of bare steel, while steel coated with Ni@Cr-G@MA is 57 times that of bare steel. Potentiodynamic polarization and EIS results show that the SHP Ni@Cr-G@MA film exhibits higher corrosion resistance than Ni@G@MA film.
Nano-liter perfusion microfluidic device made entirely by two-photon polymerization for dynamic cell culture with easy cell recovery
Authors: McLennan Hanna J. , Blanch Adam J. , Wallace Samuel J. , Ritter Lesley J. , Heinrich Shauna L. , Gardner David K. , Dunning Kylie R. , Gauvin Marty J. , Love Allison K. , Thompson Jeremy G.
Published: January 2023

Polydimethylsiloxane (PDMS) has been the material of choice for microfluidic applications in cell biology for many years, with recent advances encompassing nano-scaffolds and surface modifications to enhance cell-surface interactions at nano-scale. However, PDMS has not previously been amenable to applications which require complex geometries in three dimensions for cell culture device fabrication in the absence of additional components. Further, PDMS microfluidic devices have limited capacity for cell retrieval following culture without severely compromising cell health. This study presents a designed and entirely 3D-printed microfluidic chip (8.8 mm × 8.2 mm × 3.6 mm) using two-photon polymerization (2PP). The ‘nest’ chip is composed of ten channels that deliver sub-microliter volume flowrates (to ~ 600 nL/min per channel) to 10 individual retrievable cell sample ‘cradles’ that interlock with the nest to create the microfluidic device. Computational fluid dynamics modelling predicted medium flow in the device, which was accurately validated by real-time microbead tracking. Functional capability of the device was assessed, and demonstrated the capability to deliver culture medium, dyes, and biological molecules to support cell growth, staining and cell phenotype changes, respectively. Therefore, 2PP 3D-printing provides the precision needed for nanoliter fluidic devices constructed from multiple interlocking parts for cell culture application.
Differential gene expression in the contralateral hemisphere of the rat brain after focal ischemia
Authors: Filippenkov Ivan B. , Remizova Julia A. , Denisova Alina E. , Stavchansky Vasily V. , Golovina Ksenia D. , Gubsky Leonid V. , Limborska Svetlana A. , Dergunova Lyudmila V.
Published: January 2023

Ischemic stroke is one of the most severe polygenic brain diseases. Here, we performed further functional genetic analysis of the processes occurring in the contralateral hemisphere (CH) after ischemia–reperfusion injury in rat brain. Comparison of RNA sequencing data for subcortical samples from the ipsilateral hemisphere (IH) and CH after 90 min of transient middle cerebral artery occlusion (tMCAO) and corresponding sham-operated (SO) controls showed four groups of genes that were associated with ischemic processes in rat brain at 24 h after tMCAO. Among them, 2672 genes were differentially expressed genes (DEGs) for IH but non-DEGs for CH, 34 genes were DEGs for CH but non-DEGs for IH, and 114 genes had codirected changes in expression in both hemispheres. The remaining 16 genes exhibited opposite changes at the mRNA level in the two brain hemispheres after tMCAO. These findings suggest that the ischemic process caused by a focal ischemia induces complex bilateral reactions at the transcriptome level in the rat brain. We believe that specific genome responses in the CH and IH may provide a useful model for the study of the potential for brain repair after stroke.
Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue
Authors: Townsend Sydney E. , Westfall Jesse J. , Navarro Jason B. , Koboldt Daniel C. , Mardis Elaine R. , Miller Katherine E. , Bedrosian Tracy A.
Published: January 2023

Somatic variants are a major cause of human disease, including neurological disorders like focal epilepsies, but can be challenging to study due to their mosaicism in bulk tissue biopsies. Coupling single-cell genotype and transcriptomic data has potential to provide insight into the role somatic variants play in disease etiology, such as by determining what cell types are affected or how the mutations affect gene expression. Here, we asked whether commonly used single-nucleus 3’- or 5’-RNA-sequencing assays can be used to derive single-nucleus genotype data for a priori known variants that are located near to either end of a transcript. To that end, we compared performance of commercially available single-nuclei 3’- and 5’- gene expression kits using resected brain samples from three pediatric patients with focal epilepsy. We quantified the ability to detect genetic variants in single-nucleus datasets depending on distance from the transcript end. Finally, we demonstrated the ability to identify affected cell types in a patient with a RHEB somatic variant causing an epilepsy-associated cortical malformation. Our results demonstrate that single-nuclei 3’ or 5’-RNA-sequencing data can be used to identify known somatic variants in single-nuclei when they are expressed within proximity to a transcript end.
Spatial filtering magnetic metasurface for misalignment robustness enhancement in wireless power transfer applications
Authors: Lazzoni Valeria , Brizi Danilo , Monorchio Agostino
Published: January 2023

In this paper, we present the design of spatial filtering magnetic metasurfaces to overcome the efficiency decay arising in misaligned resonant inductive Wireless Power Transfer systems. At first, we describe the analytical framework for the control of currents flowing on a finite-size metasurface, avoiding classical truncation effects on the periphery and opportunely manipulating, at the same time, the spatial magnetic field distribution produced by the closely placed RF driving coil. In order to validate the theoretical approach, we conceive a numerical test case consisting of a WPT system operating at 12 MHz. By performing accurate full-wave simulations, we prove that inducing a uniform current in the metasurface results in a more robust WPT system in terms of misalignment with respect to conventional configurations, also including standard metasurfaces. Therefore, while the use of metasurfaces in WPT systems has been already demonstrated to be beneficial in terms of efficiency enhancement, we confirmed that a proper control of the metasurfaces field filtering response can be advantageous also for the misalignment issue. Notably, the free space wavelength at the operating frequency (12 MHz) is 25 m, whereas the proposed metasurface dimensions are only 0.0024λ × 0.0024λ. Despite the extremely reduced dimensions, the spatial magnetic field distribution produced by the closely placed RF driving coil can be nevertheless opportunely manipulated. Finally, experimental measurements conducted on fabricated prototypes validated the numerical results, demonstrating the effectiveness of the proposed approach. These achievements can be particularly helpful in WPT applications where the position of driving and receiving coils frequently changes, as in consumer devices and biomedical implants.
Salmonella enterica serovars in absence of ttrA and pduA genes enhance the cell immune response during chick infections
Authors: Cabrera Julia M. , Saraiva Mauro M. S. , Rodrigues Alves Lucas B. , Monte Daniel F. M. , Vasconcelos Rosemeri O. , Freitas Neto Oliveiro C. , Berchieri Junior Angelo
Published: January 2023

Salmonella spp. is one of the major foodborne pathogens responsible for causing economic losses to the poultry industry and bringing consequences for public health as well. Both the pathogen survival ability in the intestinal environment during inflammation as well as their relationship with the host immune system, play a key role during infections in poultry. The objective of this study was to quantify the presence of the macrophages and CD4+/CD8+ cells populations using the immunohistochemistry technique, in commercial lineages of chickens experimentally infected by wild-type and mutant strains of Salmonella Enteritidis and Salmonella Typhimurium lacking ttrA and pduA genes. Salmonella Enteritidis ∆ttrA∆pduA triggered a higher percentage of the stained area than the wild-type, with exception of light laying hens. Salmonella Typhimurium wild-type strain and Salmonella Typhimurium ∆ttrA∆pduA infections lead to a similar pattern in which, at 1 and 14 dpi, the caecal tonsils and ileum of birds showed a more expressive stained area compared to 3 and 7 dpi. In all lineages studied, prominent infiltration of macrophages in comparison with CD4+ and CD8+ cells was observed. Overall, animals infected by the mutant strain displayed a positively stained area higher than the wild-type. Deletions in both ttrA and pduA genes resulted in a more intense infiltration of macrophages and CD4+ and CD8+ cells in the host birds, suggesting no pathogen attenuation, even in different strains of Salmonella.
Accumulation of retrotransposons contributes to W chromosome differentiation in the willow beauty Peribatodes rhomboidaria (Lepidoptera: Geometridae)
Authors: Hejníčková Martina , Dalíková Martina , Zrzavá Magda , Marec František , Lorite Pedro , Montiel Eugenia E.
Published: January 2023

The W chromosome of Lepidoptera is typically gene-poor, repeat-rich and composed of heterochromatin. Pioneering studies investigating this chromosome reported an abundance of mobile elements. However, the actual composition of the W chromosome varies greatly between species, as repeatedly demonstrated by comparative genomic hybridization (CGH) or fluorescence in situ hybridization (FISH). Here we present an analysis of repeats on the W chromosome in the willow beauty, Peribatodesrhomboidaria (Geometridae), a species in which CGH predicted an abundance of W-enriched or W-specific sequences. Indeed, comparative analysis of male and female genomes using RepeatExplorer identified ten putative W chromosome-enriched repeats, most of which are LTR or LINE mobile elements. We analysed the two most abundant: PRW LINE-like and PRW Bel-Pao. The results of FISH mapping and bioinformatic analysis confirmed their enrichment on the W chromosome, supporting the hypothesis that mobile elements are the driving force of W chromosome differentiation in Lepidoptera. As the W chromosome is highly underrepresented in chromosome-level genome assemblies of Lepidoptera, this recently introduced approach, combining bioinformatic comparative genome analysis with molecular cytogenetics, provides an elegant tool for studying this elusive and rapidly evolving part of the genome.
Diversity of binary toxin positive Clostridioides difficile in Korea
Authors: Kim Jieun , Kim Bongyoung , Pai Hyunjoo
Published: January 2023

The objective of this study is to determine the trend and diversity of binary toxin-positive Clostridioides difficile over 10 years in Korea. Binary toxin-positive strains were selected from a tertiary hospital in Korea in 2009–2018. The multi-locus sequence typing and antibiotic susceptibility test were performed. Among the 3278 isolates in 2009–2018, 58 possessed binary toxin genes (1.7%). The proportion of CDT- positive isolates was 0.51–4.82% in 2009–2018, which increased over the 10-year period (P = 0.023). Thirteen sequence types (STs) were identified; ST5 (14 [24%]), ST11 (11 [19%]), ST221 (10 [17%]), ST201 (7 [12%]) and ST1 (5 [9%]) were popular. All 58 isolates were susceptible to vancomycin and piperacillin/tazobactam, and clindamycin and moxifloxacin were active in 69.0% and 62% of isolates, respectively. ST1 strains were resistant to several antibiotics, including moxifloxacin (80%), clindamycin (60%) and rifaximin (60%). Moreover, four of five ST1 presented a metronidazole minimum inhibitory concentration of 4 µg/mL. Moxifloxacin resistance was highest (72.3%) for ST11. In conclusion, binary toxin-positive strains are non-prevalent in Korea and involve diverse STs. ST1 strains were resistant to several antibiotics.
Chemical composition of Lavatera thuringiaca L. biomass ash after pre-sowing stimulation of seeds with He–Ne laser light
Authors: Budzeń Małgorzata , Zając Grzegorz , Sujak Agnieszka , Szyszlak-Bargłowicz Joanna , Kafarski Marcin
Published: January 2023

The article presents the effect of pre-sowing Lavatera thuringiaca L. seeds stimulation with He–Ne laser light on the chemical composition (P, S, K, Ca, Mn, Fe, Ni, Cu and Zn content) of ash obtained after combustion of shoots of different ages. Results varied, but it was confirmed that pre-sowing exposure of seeds to this physical factor for 10-min has the most pronounced effect on K, Cu and Mn content increase (6%, 20%, 31% increase respectively) in the ash after the first year of vegetation as well as on Cu, K and Zn content increase (9%, 19%, 22% increase respectively) after the second year of vegetation. However, 30-min stimulation significantly increases Ca (8%), Mn (20%) and Fe (72%) content in ash after the second year as well as results in ash richer in Ca (22%), P (48%), K (70%) and Zn (95%) after the third year of Lavatera vegetation. The pre-sowing application of He–Ne laser light depending on the time of stimulation can intensify the content of preferable macro- and microelement groups in Lavatera ash, in respective cultivation years. It can be an innovative method of biomass ash enhancement and its more effective use in agriculture as commercial fertilizers substitute.
Systemic factors associated with 10-year glaucoma progression in South Korean population: a single center study based on electronic medical records
Authors: Yoon Jung Suk , Kim Ye-eun , Lee Eun Ji , Kim Hyunjoong , Kim Tae-Woo
Published: January 2023

Glaucoma is a multifactorial disease where various systemic features are involved in the progression of the disease. Based on initial systemic profiles in electronic medical records, this study aimed to develop a model predicting factors of long-term rapid retinal nerve fiber layer (RNFL) thinning over 5 years in 505 patients with primary open-angle glaucoma. Eyes with faster or slower RNFL thinning were stratified using a decision tree model, and systemic and ophthalmic data were incorporated into the models based on random forest and permutation methods, with the models interpreted by Shapley additive explanation plots (SHAP). According to the decision tree, a higher lymphocyte ratio (> 34.65%) was the most important systemic variable discriminating faster or slower RNFL thinning. Higher mean corpuscular hemoglobin (> 32.05 pg) and alkaline phosphatase (> 88.0 IU/L) concentrations were distinguishing factors in the eyes with lymphocyte ratios > 34.65% and < 34.65%, respectively. SHAP demonstrated larger baseline RNFL thickness, greater fluctuation of intraocular pressure (IOP), and higher maximum IOP as the strongest ophthalmic factors, while higher lymphocyte ratio and higher platelet count as the strongest systemic factors associated with faster RNFL thinning. Machine learning-based modeling identified several systemic factors as well as previously acknowledged ophthalmic risk factors associated with long-term rapid RNFL thinning.
Feasibility of an NIR spectral calibration transfer algorithm based on optimized feature variables to predict tobacco samples in different states
Authors: Geng Yingrui , Ni Hongfei , Shen Huanchao , Wang Hui , Wu Jizhong , Pan Keyu , Wu Yongjiang , Chen Yong , Luo Yingjie , Xu Tengfei , Liu Xuesong
Published: January 2023

NIR spectral calibration transfer based on optimized feature variables to predict different states of tobacco sample.
Efficient determination of non-steroidal anti-inflammatory drugs by micellar electrokinetic chromatography in wastewater
Authors: Alatawi Hanan , Hogan Anna , Albalawi Ibtihaj , Alsefri Samia , Moore Eric
Published: January 2023

Recently, non-steroidal anti-inflammatory drugs (NSAIDs) have been increasingly used in humans and animals.
Increasing the ferroelastic phase transition temperature of hybrid perovskites through a mixed phosphonium and ammonium cation strategy
Authors: Mu Jie , Xu Ke , He Lei , Xu Yan , Yin Ti-Jian , Men Jin-Tao , Ye Qiong
Published: January 2023

The introduction of phosphonium cations increases the ferroelastic phase transition temperature of [(CH3)3PCH2CH2CH3]2(n-C4H9NH3)Bi2Br9 to above room temperature.
Binaphthol-based chiral host molecules for efficient solution-processed circularly polarized OLEDs
Authors: Dong Qiwei , Xiao Chen , He Binghong , Yang Xuefeng , Zeng Songkun , Zhong Qihang , Duan Pengfei , Zhu Weiguo , Wang Yafei
Published: January 2023

Two chiral hosts, named (R/S)-BN-mCP and (R/S)-BN-2mCP, are prepared. The solution processable CP-OLED based on chiral host and achiral phosphorescent emitter presents the best performance with an EQEmaxof 17.1% and thegELof﹣1.3 × 10−3.
Electrodepositing amorphous molybdenum oxides for aqueous NH4+ storage
Authors: Lin Yulai , Ta Lintuoya , Meng Jianming , Song Yu , Liu Xiao-Xia
Published: January 2023

We fabricated a series of amorphous molybdenum oxide materials for aqueous NH4+ storage. The valence state of Mo and the content of Mo–OH component in MoOx synergistically control the NH4+ storage performance of Mo-based materials.
Charge trapped CdS quantum dot embedded polymer matrix for a high speed and low power memristor
Authors: Betal Atanu , Bera Jayanta , Sharma Ashish , Rath Arup K. , Sahu Satyajit
Published: January 2023

High-quality CdS quantum dots embedded in the polymer matrix device showed extremely stable electrical switching behaviour.
Selective etching mechanism of silicon oxide against silicon by hydrogen fluoride: a density functional theory study
Authors: Hidayat Romel , Kim Hye-Lee , Khumaini Khabib , Chowdhury Tanzia , Mayangsari Tirta Rona , Cho Byungchul , Park Sangjoon , Lee Won-Jun
Published: January 2023

The mechanism underlying the selective etching of silicon oxide against silicon by HF vapor was elucidated by DFT calculations that showed lower activation energies for silicon oxide than for silicon.
Stepwise hydrations of anhydride tuned by hydrogen bonds: rotational study on maleic anhydride-(H2O)1–3
Authors: Li Jiayi , Wang Xiujuan , Zhang Xinyue , Chen Junhua , Wang Hao , Tian Xiao , Xu Xuefang , Gou Qian
Published: January 2023

The rotational spectra of maleic anhydride-(H2O)1–3 have been investigated for the first time by using pulsed jet Fourier transform microwave spectroscopy with complementary computational analyses.
Noncovalent bonding assessment by pair distribution function
Authors: Saunders Lucy K. , Irving Daniel , Chater Philip A. , Diaz-Lopez Maria
Published: January 2023

X-ray pair distribution function analyses can improve our understanding of local structural deviations resulting from noncovalent bonds and guide the development of novel functional materials.
Synthesis of unsymmetrical NH-pyrroles from biomass feedstock in the confined space of metal–organic frameworks
Authors: Zheng Deng-Yue , Zhang Tianjian , Bai Rongxian , Li Minghao , Wang Ruifeng , Gu Yanlong
Published: January 2023

The confinement effect of the NH2-decorated MOF-based catalysts enables the development of a new route for the synthesis of unsymmetrically substituted NH-pyrroles from 3-aminocrotonates and α-hydroxyketones.
Microfluidic solutions for biofluids handling in on-skin wearable systems
Authors: Kashaninejad Navid , Nguyen Nam-Trung
Published: January 2023

The paper provides a comprehensive review on micro elastofluidic solutions for on-skin wearable devices.
Synthesis, antimicrobial and ergosterol biosynthesis inhibition activity of clubbed 1,1′-biphenyl-pyrazole derivatives
Authors: Walunj Yogesh , Nandurkar Yogesh , Shinde Abhijit , Jagadale Shivaji , Shaikh Abdul Latif N. , Modak Manisha , Mhaske Pravin C.
Published: January 2023

Synthesis, antimicrobial and ergosterol biosynthesis inhibition activity of clubbed 1,1′-biphenyl-pyrazole derivatives.
Study of the interactions between lactic acid-based deep eutectic solvents and bovine serum albumin
Authors: Guo Jingjing , Fu Li , Wang Qian , Peng Yuling , Yuan Yaoyao , Lin Deyu , Sun Yuehui , Wang Hui , Guo Tong
Published: January 2023

The interactions between bovine serum albumin (BSA) and four lactic acid-based deep eutectic solvents (LADESs) were studied by spectroscopic and electrochemical methods under simulated physiological conditions.
Synthesis of magnetic date stone biochar for solid phase extraction of NSAIDs from water samples
Authors: Bensghaier Rafika , Snoussi Aziza , Aouled Abdallah Marwa , Latrous Latifa , Megriche Adel
Published: January 2023

A new date stone biochar was synthesized and used for the first time for magnetic solid phase extraction of NSAIDs.
Mechanistic insights into silica nanoparticle–allergen interactions on antigen presenting cell function in the context of allergic reactions
Authors: Johnson Litty , Aglas Lorenz , Punz Benjamin , Dang Hieu-Hoa , Christ Constantin , Pointner Lisa , Wenger Mario , Hofstaetter Norbert , Hofer Sabine , Geppert Mark , Andosch Ancuela , Ferreira Fatima , Horejs-Hoeck Jutta , Duschl Albert , Himly Martin
Published: January 2023

Impact of SiO2 NP-allergen interaction on dendritic cell function altering the immune response, eventually resulting in a harmless, beneficial outcome in terms of allergic reactivity.
Tuning the 1T′/2H phases in WxMo1−xSe2 nanosheets
Authors: Sokolikova Maria S. , Cheng Gang , Och Mauro , Palczynski Pawel , El Hajraoui Khalil , Ramasse Quentin M. , Mattevi Cecilia
Published: January 2023

Nanomaterial morphology, chemical composition and 1T′/2H crystal phase tuning is achieved in colloidal WxMo1−xSe2 nanosheets synthesised by a direct colloidal reaction.
Diagnosis of nasopharyngeal carcinoma using an ultrasensitive immunoassay method based on nanoparticles
Authors: Gong Rui , Yang Chenyang , Abbas Ghulam , Wang Dianbing , Zhang Xianen , Nie Guohui , Ding Hui
Published: January 2023

The rapid detection of the antibody of Epstein–Barr virus (EBV) is critical for the diagnosis of nasopharyngeal carcinoma (NPC).
Solar driven CO2 reduction with a molecularly engineered periodic mesoporous organosilica containing cobalt phthalocyanine
Authors: Angeles Navarro M. , Sain Sunanda , Wünschek Maximilian , Pichler Christian M. , Romero-Salguero Francisco J. , Esquivel Dolores , Roy Souvik
Published: January 2023

Efficient CO2 photoreduction to CO with >70% product selectivity over a periodic mesoporous organosilica-based heterogeneous catalyst containing molecular cobalt phthalocyanine units.
Macrophage-targeted nanoparticles mediate synergistic photodynamic therapy and immunotherapy of tuberculosis
Authors: Tian Na , Duan Huijuan , Cao Tingming , Dai Guangming , Sheng Gang , Chu Hongqian , Sun Zhaogang
Published: January 2023

A metal–organic framework-based nanotheranostic system was fabricated to achieve a macrophage-targeting ability and combined photodynamic and immunotherapy for Mtb.
The impact of silver nanoclay functionalisation on optical and electrochemical properties
Authors: Timakwe Sapokazi , Silwana Bongiwe , Matoetoe Mangaka C.
Published: January 2023

Three different fractions of nanoclay (nanomer 1.44P) were functionalised with Ag forming silver nanoclay composites (Ag/nanomer 1.44P).
A dual-functional catalyst: wood-templated BiVO4–CdS for wood dye wastewater
Authors: Xia Guangda , Xiao Sichen , Su Junjie , Zhou Hui , Liu Yu , Zhu Xiaodong
Published: January 2023

A large quantity of wastewater is released from wood processing, posing a serious pollution problem to the natural environment.
Synthesis of a ZSM-5 (core)/SAPO-11 (shell) composite zeolite and its catalytic performance in the methylation of naphthalene with methanol
Authors: Wang Xiaoxiao , Guo Shilong , Niu Ziyan
Published: January 2023

In the present work, ZSM-5 (core)/SAPO-11 (shell) composite was prepared by the hydrothermal method and characterized by XRD, SEM, NH3-TPD, and other techniques. The catalytic performances of ZSM-5/SAPO-11 for the methylation of naphthalene with methanol was studied.
Sequential hydrogenation of nitroaromatics to alicyclic amines via highly-dispersed Ru–Pd nanoparticles anchored on air-exfoliated C3N4 nanosheets
Authors: Wu Jiale , Wang Liguo , Xu Shuang , Cao Yan , Han Ziqiang , Li Huiquan
Published: January 2023

Ru–Pd dual active site catalyst exhibited more excellent performance in sequential hydrogenation of nitroaromatics to alicyclic amines.
Doping of charge-transfer molecules in cocrystals for the design of materials with novel piezo-activated luminescence
Authors: Yin Xiu , Zhai Chunguang , Hu Shuhe , Yue Lei , Xu Tongge , Yao Zhen , Li Quanjun , Liu Ran , Yao Mingguang , Sundqvist Bertil , Liu Bingbing
Published: January 2023

Doping of charge-transfer molecules in PTCs cocrystals has been developed for the design of materials with novel piezo-activated luminescence, showing an anomalous blue shift and unexpected giant luminescence enhancement behavior.
CD95/Fas ligand induced toxicity
Authors: Haluck-Kangas Ashley , Peter Marcus E.
Published: January 2023

The role of CD95/Fas ligand (CD95L/FasL) in the induction of CD95-mediated extrinsic apoptosis is well characterized. Trimerized, membrane-bound CD95L ligates the CD95 receptor activating downstream signaling resulting in the execution of cells by caspase proteins. However, the expression of CD95L has been reported to induce cell death in contexts in which this pathway is unlikely to be activated, such as in cell autonomous activation induced cell death (AICD) and in CD95-resistant cancer cell lines. Recent data suggests that the CD95L mRNA exerts toxicity through death induced by survival gene elimination (DISE). DISE results from the targeting of networks of survival genes by toxic short RNA (sRNA)s in the RNA-induced silencing complex (RISC). CD95L mRNA contributes to this death directly, through the processing of its mRNA into toxic sRNAs that are loaded into the RISC, and indirectly, by promoting the loading of other toxic sRNAs. Interestingly, CD95L is not the only mRNA that is processed and loaded into the RISC. Protein-coding mRNAs involved in protein translation are also selectively loaded. We propose a model in which networks of mRNA-derived sRNAs modulate DISE, with networks of genes providing non-toxic RISC substrate sRNAs that protect against DISE, and opposing networks of stress-activated genes that produce toxic RISC substrate sRNAs that promote DISE.
Therapeutic targeting of TRAIL death receptors
Authors: Di Cristofano Francesca , George Andrew , Tajiknia Vida , Ghandali Maryam , Wu Laura , Zhang Yiqun , Srinivasan Praveen , Strandberg Jillian , Hahn Marina , Sanchez Sevilla Uruchurtu Ashley , Seyhan Attila A. , Carneiro Benedito A. , Zhou Lanlan , Huntington Kelsey E. , El-Deiry Wafik S.
Published: January 2023

The discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the development of TRAIL receptor agonists (TRAs), including recombinant human TRAIL (rhTRAIL) and TRAIL receptor-targeted agonistic antibodies. While such TRAIL pathway-targeted therapies showed promise in preclinical data and clinical trials have been conducted, none have advanced to FDA approval. Subsequent second-generation approaches focused on improving upon the specific limitations of first-generation approaches by ameliorating the pharmacokinetic profiles and agonistic abilities of TRAs as well as through combinatorial approaches to circumvent resistance. In this review, we summarize the successes and shortcomings of first- and second-generation TRAIL pathway-based therapies, concluding with an overview of the discovery and clinical introduction of ONC201, a compound with a unique mechanism of action that represents a new generation of TRAIL pathway-based approaches. We discuss preclinical and clinical findings in different tumor types and provide a unique perspective on translational directions of the field.
The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration
Authors: Budvytyte Rima , Valincius Gintaras
Published: January 2023

Misfolding, aggregation and accumulation of Amyloid-β peptides (Aβ) in neuronal tissue and extracellular matrix are hallmark features of Alzheimer's disease (AD) pathology. Soluble Aβ oligomers are involved in neuronal toxicity by interacting with the lipid membrane, compromising its integrity, and affecting the function of receptors. These facts indicate that the interaction between Aβ oligomers and cell membranes may be one of the central molecular level factors responsible for the onset of neurodegeneration. The present review provides a structural understanding of Aβ neurotoxicity via membrane interactions and contributes to understanding early events in Alzheimer's disease.
Retracted: Multi‐mode urban rail transit and spatial coordinated development based on deep learning system
Authors: Wang Xiaojian , Wang Zixuan , Sun Xiaoye
Published: January 2023

Retraction: [Xiaojian Wang, Zixuan Wang, Xiaoye Sun, Multi‐mode urban rail transit and spatial coordinated development based on deep learning system, IET Circuits, Devices & Systems 2023 (https://doi.org/10.1049/cds2.12144)].

The above article from IET Circuits, Devices & Systems, published online on 10 January 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Harry E. Ruda, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer revie process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Smartphone sensors‐based human activity recognition using feature selection and deep decision fusion
Authors: Zhang Yijia , Yao Xiaolan , Fei Qing , Chen Zhen
Published: January 2023

Human activity recognition (HAR) with smartphone sensors is a significant research direction in human‐cyber‐physical systems. Aiming at the problem of feature redundancy and low recognition accuracy of HAR, this paper presents a novel system architecture comprising three parts: feature selection based on an oppositional and chaos particle swarm optimization (OCPSO) algorithm, multi‐input one‐dimensional convolutional neural network (MI‐1D‐CNN) utilizing time‐domain and frequency‐domain signals, and deep decision fusion (DDF) combining D‐S evidence theory and entropy. The proposed architecture is evaluated on the UCI HAR and WIDSM datasets. The results highlight that OCPSO performs better than particle swarm optimization (PSO) in feature selection, convergence speed, and recognition accuracy. Moreover, it is shown that for the MI‐1D‐CNN classifier, the frequency‐domain signals (95.96%) perform better than time‐domain signals (95.66%). In addition, this paper investigates the impact of the convolution layers, feature maps, filter sizes, and decision fusion methods on recognition accuracy. The results demonstrate that the DDF method (97.81%) outperforms single‐layer decision fusion in improving the recognition accuracy on the UCI HAR dataset.
A novel smoke detection algorithm based on improved mixed Gaussian and YOLOv5 for textile workshop environments
Authors: Chen Xin , Xue Yipeng , Zhu Yaolin , Ma Ruiqing
Published: January 2023

There are a lot of flammable materials in the textile workshop, and once a fire occurs, it will cause property damage and casualties. At present, smoke detection in textile workshops mainly relies on temperature‐sensing smoke sensors with low detection rate and poor real‐time performance, which cannot meet the task of smoke detection in complex environments. Therefore, this paper proposes an improved mixed Gaussian and YOLOv5 smoke detection algorithm for textile workshops. In order to reduce the interference of static background in smoke detection, an improved gaussian mixture algorithm is used to extract suspected smoke areas in video by using the dynamic characteristics of smoke. Then, an adaptive attention module is added to the feature pyramid infrastructure of the YOLOv5 target detection network to improve the multi‐scale target recognition ability. In addition, the focal loss function is used to reduce the impact of background and foreground class imbalances on the detection results. The experimental results show that the detection accuracy of the proposed method is 94.7%, and the average detection speed is 66.7 FPS. By comparing with the existing state‐of‐the‐art algorithms, the detection capability of this method has been significantly improved. At the same time, it has high real‐time performance and detection accuracy in smoke detection in textile workshops.
Research on the development of island tourism market for college students - a case study of Dongji Island
Authors: Sun Hang , Zhang Yulin , Chen Danni
Published: January 2023

In recent years, with the acceleration of the process of economic globalization, China's rapid economic growth and increasingly convenient transportation, college students' tourism activities are increasing. At the same time, the uniqueness of Island tourism resources determines the irreplaceable industrial status of Island tourism. Dongji Island, affiliated to Zhoushan City, Zhejiang Province, has extremely rich natural and cultural resources, and its tourism industry has a high correlation with college students. In view of this, based on the analysis of the current situation of the island tourism industry in Dongji Island, reasonable island tourism development and external publicity measures are proposed for college students.