bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence, predictors and management of left atrial appendage thrombogenic milieu in atrial fibrillation with low thromboembolic risk
Authors: Qiao Yu , Zhao Zhen , Cai Xiang , Guo Yulong , Liu Ke , Guo Jinrui , Guo Tao , Niu Guodong
Published: March 2023

Background

The present study aimed to investigate the prevalence, predictors, and management of left atrial appendage (LAA) thrombogenic milieu (TM) identified with transesophageal echocardiography (TEE) in non-valvular atrial fibrillation (NVAF) patients with low to moderate thromboembolic (TE) risk.

Methods

We retrospectively analyzed the baseline clinical data and TEE findings in 391 NVAF patients (54.7 ± 8.9 years, 69.1% male) with low to moderate TE risk according to the CHA2DS2-VASc score. LAA TM was defined as LAA thrombus (LAAT), sludge or spontaneous echo contrast (SEC). Management of LAA TM was at the discretion of the treating physician.

Results

A total of 43 patients (11.0%) were detected with LAA TM, including 5 with LAAT (11.6%), 4 with LAAT + Sect. (9.3%), 3 with sludge (7.0%), and 31 with Sect. (72.1%). In multivariate model, non-paroxysmal AF (OR 3.121; 95% CI 1.205–8.083, p = 0.019), and a larger left atrial diameter (LAD) (OR 1.134; 95% CI 1.060–1.213, p < 0.001) were significantly associated with the presence of LAA TM. All LAATs or sludges effectively resolved after mean duration of 117.5 ± 20.0 days for oral anticoagulant (OAC) medication. TE events occurred in 3 patients (18.8%) among those discontinuing OAC over a mean follow-up of 26.2 ± 8.8 months, while no TE events occurred in patients with continuous OAC.

Conclusions

LAA TM could be identified in 11.0% in NVAF patients with low to moderate TE risk, especially in those with non-paroxysmal AF and enlarged LAD. Short-term OAC medication could effectively resolve the LAAT or sludge.
The effects of a low carbohydrate diet combined with partial meal replacement on obese individuals
Authors: Zhong Yulian , Chen Ximin , Huang Chao , Chen Yuexiao , Zhao Fengyi , Hao Runhua , Wang Niannian , Liao Wang , Xia Hui , Yang Ligang , Wang Shaokang , Sun Guiju
Published: March 2023

Objective

We explored the dietary effects of replacing normal dietary staple foods with supplementary nutritional protein powder, dietary fiber, and fish oil on several metabolic parameters. We examined weight loss, glucose and lipid metabolism, and intestinal flora in obese individuals when compared with individuals on a reduced staple food low carbohydrate diet.

Methods

From inclusion and exclusion criteria, 99 participants (28 kg/m2 ≤ body mass index (BMI) ≤ 35 kg/m2) were recruited and randomly assigned to control and intervention 1 and 2 groups. Physical examinations and biochemical indices were performed/gathered before the intervention and at 4 and 13 weeks post intervention. After 13 weeks, feces was collected and 16s rDNA sequenced.

Results

After 13 weeks, when compared with controls, body weight, BMI, waist circumference, hip circumference, systolic blood pressure, and diastolic blood pressure values in intervention group 1 were significantly reduced. In intervention group 2, body weight, BMI, waist circumference, and hip circumference were significantly reduced. Triglyceride (TG) levels in both intervention groups were significantly reduced. Fasting blood glucose, glycosylated hemoglobin, glycosylated albumin, total cholesterol, and apolipoprotein B levels in intervention group 1 were decreased, while high density lipoprotein cholesterol (HDL-c) decreased slightly. Glycosylated albumin, TG, and total cholesterol levels in intervention group 2 decreased, while HDL-c decreased slightly, High sensitive C-reactive protein, MPO, Ox-LDL, LEP, TGF-β1, IL-6, GPLD1, pro NT, GPC-4, and LPS levels in both intervention groups were lower when compared with controls. Adiponectin (ADPN) levels in intervention groups were higher when compared with controls. Tumor necrosis factor-α (TNF-α) levels in intervention group 1 were lower when compared with controls. There is no obvious difference in α diversity and β diversity between intestinal flora of 3 groups. Among the first 10 species of Phylum, only the control group and the intervention group 2 had significantly higher Patescibacteria than the intervention group 1. Among the first 10 species of Genus, only the number of Agathobacter in intervention group 2 was significantly higher than that in control group and intervention group 1.

Conclusions

We showed that an LCD, where nutritional protein powder replaced some staple foods and dietary fiber and fish oil were simultaneously supplemented, significantly reduced weight and improved carbohydrate and lipid metabolism in obese individuals when compared with an LCD which reduced staple food intake.
Emergency administration of fibrinogen concentrate for haemorrhage: systematic review and meta-analysis
Authors: Itagaki Yuki , Hayakawa Mineji , Takahashi Yuki , Hirano Satoshi , Yamakawa Kazuma
Published: March 2023

Introduction

The occurrence of massive haemorrhages in various emergency situations increases the need for blood transfusions and increases the risk of mortality. Fibrinogen concentrate (FC) use may increase plasma fibrinogen levels more rapidly than fresh-frozen product or cryoprecipitate use. Previous several systematic reviews and meta-analyses have not effectively demonstrated FC efficacy in significantly improving the risk of mortality and reducing transfusion requirements. In this study, we investigated the use of FC for haemorrhages in emergency situations.

Methods and analysis

In this systematic review and meta-analysis, we included controlled trials, but excluded randomized controlled trials (RCTs) in elective surgeries. The study population consisted of patients with haemorrhages in emergency situations, and the intervention was emergency supplementation of FC. The control group was administered with ordinal transfusion or placebo. The primary and secondary outcomes were in-hospital mortality and the amount of transfusion and thrombotic events, respectively. The electronic databases searched included MEDLINE (PubMed), Web of Science, and the Cochrane Central Register of Controlled Trials.

Results

Nine RCTs in the qualitative synthesis with a total of 701 patients were included. Results showed a slight increase in in-hospital mortality with FC treatment (RR 1.24, 95% CI 0.64–2.39, p = 0.52) with very low certainty of the evidence. There was no reduction in the use of red blood cells (RBC) transfusion in the first 24 h after admission with FC treatment (mean difference [MD] 0.0 Unit in the FC group, 95% CI − 0.99–0.98, p = 0.99) with very low certainty of the evidence. However, the use of fresh-frozen plasma (FFP) transfusion significantly increased in the first 24 h after admission with FC treatment (MD 2.61 Unit higher in the FC group, 95% CI 0.07–5.16, p = 0.04). The occurrence of thrombotic events did not significantly differ with FC treatment.

Conclusions

The present study indicates that the use of FC may result in a slight increase in in-hospital mortality. While FC did not appear to reduce the use of RBC transfusion, it likely increased the use of FFP transfusion and may result in a large increase in platelet concentrate transfusion. However, the results should be interpreted cautiously due to the unbalanced severity in the patient population, high heterogeneity, and risk of bias.
Effect of Remote Peer-Counsellor- delivered Behavioral Activation and Peer-support for Antenatal Depression on Gestational Age at Delivery: a single-blind, randomized control trial
Authors: Chaput Kathleen H. , Freeman Makayla , McMorris Carly , Metcalfe Amy , Cameron Emily E. , Jung James , Tough Suzanne , Hicks Laurel M. , Dimidjian Sona , Tomfohr-Madsen Lianne M.
Published: March 2023

Background

Antenatal depression (AD) is the most common complication of pregnancy in developed countries and increases the risk of preterm birth (PTB). Many pregnant individuals with AD do not obtain treatment due in part to risks associated with antidepressant medications, the expense and wait times for psychological services, and perceived stigma. Accessible and timely treatment of antenatal depression is crucial to minimize foetal impacts and associated long-term child health outcomes. Previous studies show that behavioural activation and peer support are promising avenues of treatment for perinatal depression. Additionally, remote and paraprofessional counselling interventions show promise as more accessible, sustainable, and cost-effective treatment avenues than traditional psychological services. The primary aim of this trial is to test the effectiveness of a remote, behavioural activation and peer support intervention, administered by trained peer para-professionals, for increasing gestational age at delivery among those with antenatal depression. The secondary aims are to evaluate the effectiveness for treating AD prior to delivery, with persistence into the postpartum; improving anxiety symptoms; and improving parenting self-efficacy compared to controls.

Methods

A two-arm, single-blinded, parallel groups randomized controlled trial (RCT) with repeated measures will be conducted. Participants scoring >10 on the Edinburgh Postnatal Depression Scale will be recruited from the larger P3 cohort and invited to enroll. Assessments will be conducted prior to 27 weeks’ gestation at trial intake (T1), post-intervention, prior to delivery (T2), 5–6 months postpartum (T3), and 11–12 months postpartum (T4) and will include self-report questionnaires and linked medical records.

Discussion

Our remote, peer paraprofessional-delivered behavioural activation plus peer support intervention has the potential to successfully reduce symptoms of AD, which may in turn decrease the risk of PTB and subsequent health impacts. The current trial builds on previous findings and uses a patient-oriented approach to address priorities for patient care and to provide a cost-effective, accessible, and evidence-based treatment to pregnant individuals with AD.

Trial registration

International Standard Randomised Controlled Trial Number (ISRCTN) registry (ISRCTN51098220) ISRCTN51098220. Registered on April 7, 2022.
Randomized controlled trial protocol of health coaching for veterans with complex chronic pain
Authors: Crosky Sarah , McFarlin Mikhaela , Sullivan Nicole , Winograd Darren , Litke David , Masheb Robin M. , Lu Shou-En , Costanzo Michelle , Anastasides Nicole , Gonzalez Christina , Doshi Jaineel , Graff Fiona , Khatib Linda , Thien Scott , McAndrew Lisa M.
Published: March 2023

Background

Pain predominant multisymptom illness (pain-CMI) refers to symptom-based conditions where pain is a primary symptom. There is initial evidence that health coaching may be efficacious in treating pain-CMI because it can be tailored to the veteran’s goals and emphasizes long-term behavior change, which may indirectly impact the maintaining factors of pain-CMI (e.g., catastrophizing, poor pain control, and limited activity). This paper describes the study protocol and rationale of a randomized controlled trial that will compare the efficacy of remote-delivered health coaching in reducing disability and pain impairment for veterans with pain-CMI to remote-delivered supportive psychotherapy.

Methods

This randomized controlled trial will consist of two treatment arms: remote-delivered health coaching and remote-delivered supportive psychotherapy, the active control. Each treatment condition will consist of twelve, weekly one-on-one meetings with a study provider. In addition to the baseline assessment, participants will also complete 6-week (mid-treatment), 12-week (post-treatment), and 24-week (follow-up) assessments that consist of questionnaires that can be completed remotely. The primary aims for this study are to determine whether health coaching reduces disability and pain impairment as compared to supportive psychotherapy. We will also examine whether health coaching reduces physical symptoms, catastrophizing, limiting activity, and increasing pain control as compared to supportive psychotherapy.

Discussion

This study will contribute to the existing literature on pain-CMI and report the effectiveness of a novel, remote-delivered behavioral intervention.
Long-term aerobic and combined exercises enhance the satiety response and modulate the energy intake in patients with type 2 diabetes mellitus (T2DM): A randomized controlled trial
Authors: Vidanage Dinithi , Wasalathanthri Sudharshani , Hettiarachchi Priyadarshika
Published: March 2023

Background

Energy homeostasis plays a vital role in achieving glycemic control in people with type 2 diabetes mellitus (T2DM). Exercise is known to increase energy expenditure. However, its role in energy intake has not been explored in people with T2DM. Thus, this study aimed at determining the impact of long-term aerobic and combined exercises in modulating hunger, satiety and energy intake in T2DM.

Methods

A randomized controlled trial, with 108 people with T2DM, aged 35–60 years were assigned into an aerobic, combined (aerobic and resistance) and a control group. Primary outcomes were subjective levels of hunger and satiety measured by a 100 mm visual analogue scale in relation to a standard breakfast meal (453 kcal) and energy and macronutrient intake determined by a 3-day diet diary at 0, 3 and 6 months.

Results

Aerobic and combined groups exhibited reduced hunger and increased satiety at 3 and 6 months (p < 0.05). The combined group demonstrated a profound increase in satiety at 3 and 6 months compared to aerobics (3 months; p = 0.008, 6 months; p = 0.002) and controls (3 months; p = 0.006, 6 months, p = 0.014). Mean daily energy intake was reduced only at 6 months in the aerobic group (p = 0.012), whereas it was reduced in the combined group at 3 and at 6 months compared to controls (3 months: p = 0.026, 6 months: p = 0.022).

Conclusions

Long-term aerobic and combined exercises produced a reduction in hunger, energy intake and increase satiety in people with T2DM. Despite energy expenditure, exercise seems to play a significant role in reducing energy intake as well. Combined exercises show more advantages over aerobic exercise since combined exercises have a greater impact on satiety and energy intake in people with T2DM.

Trial registration number: SLCTR/2015/029, https://slctr.lk/trials/slctr-2015-029.
Granulosa tumor: two spontaneous pregnancies after combined medico-surgical treatment: case report and review of the literature
Authors: Kaakoua Mohamed , Chidiac Jean , Notf Andrianandrasana , Chen Ruiqian , Mahe Isabelle , Djennaoui Sadji
Published: March 2023

Background

Granulosa tumor is a rare tumor that arises from the mesenchyme and the sexual cord of the ovary. The prognosis is generally excellent, and treatment is mainly based on surgery, followed by chemotherapy depending on the extension of the disease. However, “the obstetrical prognosis” is compromised.

Case presentation

We report the case of a 32-year-old Caucasian patient who was diagnosed during a primary infertility assessment with an ultrasound image of a 39 mm organic left ovarian cyst confirmed on pelvic magnetic resonance imaging with infiltration of the uterosacral space. Tumor markers, including cancer antigen 125, alpha fetoprotein, and β-human chorionic gonadotropin, were normal. Histological study of biopsies of the ovarian lesion taken during exploratory laparoscopy confirmed the diagnosis of adult granulosa tumor. After a normal extension assessment including a thoracoabdominopelvic computed tomography scan and a positron emission tomography scan, the patient underwent complete conservative surgery and the disease was classified as stage Ic. Three cycles of adjuvant chemotherapy according to the “BEP” protocol combining bleomycin, etoposide, and cisplatin were performed after oocyte cryopreservation. After a 5-year follow-up period, the patient had no sign of tumor progression and had two spontaneous pregnancies, the first occurring 3 months after the end of chemotherapy and the second 14 months later.

Conclusion

Granulosa cell tumor remains a rare tumor whose management considerably compromises fertility and reduces the chances of having a spontaneous pregnancy. The particularity of our observation is that the diagnosis of the granulosa tumor was made following a primary infertility assessment and that the patient had two spontaneous pregnancies 3 months after the end of a medico-surgical treatment known to be very gonadotoxic.
Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature
Authors: Toyodome Soichiro , Wakasa Tomoko , Hirose Katsutoshi , Iwamoto Noriko , Suzuki Seiya , Nemoto Naoto , Toyosawa Satoru , Nagata Tetsuji
Published: March 2023

Background

Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local infiltration of the odontogenic epithelium or recurrences have been reported, and its detailed pathology and treatments remain unclear.

Case presentation

This report describes the case of a 60-year-old Japanese male diagnosed with a maxillary dentinogenic ghost cell tumor. Images showed well-circumscribed, multilocular cystic lesions with a calcified substance in the interior. Marsupialization was performed along with biopsy to prevent the expansion of the lesion, and a partial maxillectomy was performed 2 years after the initial examination. Histopathological findings showed ameloblastomatous proliferation containing clusters of ghost cells and dentinoid materials, resulting in the diagnosis of dentinogenic ghost cell tumor. This article also reviews recently reported cases of dentinogenic ghost cell tumor.

Conclusion

It is important to perform marsupialization, proper resection, and postoperative follow-up because of possible recurrence.
Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors
Authors: de Jager Nienke S. , van Oostenbrugge Tim J. , Pätz Torben , Jenniskens Sjoerd F. M. , Fütterer Jurgen J. , Langenhuijsen Johan F. , Overduin Christiaan G.
Published: March 2023

Purpose

To assess volumetric ablation margins derived from intraoperative pre- and post-ablation MRI after magnetic resonance imaging (MRI)-guided percutaneous cryoablation of renal tumors and explore its correlation with local treatment success.

Methods

Retrospective analysis was performed on 30 patients (mean age 69y) who underwent percutaneous MRI-guided cryoablation between May 2014 and May 2020 for 32 renal tumors (size: 1.6–5.1 cm). Tumor and ice-ball volumes were segmented on intraprocedural pre- and post-ablation MR images using Software Assistant for Interventional Radiology (SAFIR) software. After MRI-MRI co-registration, the software automatically quantified the minimal treatment margin (MTM),defined as the smallest 3D distance between the tumor and ice-ball surface. Local tumor progression (LTP) after cryoablation was assessed on follow-up imaging.

Results

Median follow-up was 16 months (range: 1–58). Local control after cryoablation was achieved in 26 cases (81%) while LTP occurred in 6 (19%). The intended MTM of ≥5 mm was achieved in 3/32 (9%) cases. Median MTM was significantly smaller for cases with (− 7 mm; IQR:-10 to − 5) vs. without LTP (3 mm; IQR:2 to 4) (P < .001). All cases of LTP had a negative MTM. All negative treatment margins occurred in tumors > 3 cm.

Conclusions

Determination of volumetric ablation margins from intraoperative MRI was feasible and may be useful in predicting local outcome after MRI-guided renal cryoablation. In our preliminary data, an intraoperative MRI-derived minimal margin extending at least 1 mm beyond the MRI-visible tumor led to local control and this was more difficult to achieve in tumors > 3 cm. Ultimately, online margin analysis may be a valuable tool to intraoperatively assess therapy success, but larger prospective studies are needed to establish a reliable threshold for clinical use.
Co-production of a feasibility trial of pacing interventions for Long COVID
Authors: Turner Grace M. , McMullan Christel , Aiyegbusi Olalekan Lee , Hughes Sarah E. , Walker Anita , Jeyes Felicity , Adler Yvonne , Chong Amy , Buckland Lewis , Stanton David , Davies Elin Haf , Haroon Shamil , Calvert Melanie
Published: March 2023

Background

The high incidence of COVID-19 globally has led to a large prevalence of Long COVID but there is a lack of evidence-based treatments. There is a need to evaluate existing treatments for symptoms associated with Long COVID. However, there is first a need to evaluate the feasibility of undertaking randomised controlled trials of interventions for the condition. We aimed to co-produce a feasibility study of non-pharmacological interventions to support people with Long COVID.

Methods

A consensus workshop on research prioritisation was conducted with patients and other stakeholders. This was followed by the co-production of the feasibility trial with a group of patient partners, which included the design of the study, the selection of interventions, and the production of dissemination strategies.

Results

The consensus workshop was attended by 23 stakeholders, including six patients. The consensus from the workshop was to develop a clinical trial platform that focused on testing different pacing interventions and resources. For the co-production of the feasibility trial, patient partners selected three pacing resources to evaluate (video, mobile application, and book) and co-designed feasibility study processes, study materials and undertook usability testing of the digital trial platform.

Conclusion

In conclusion, this paper reports the principles and process used to co-produce a feasibility study of pacing interventions for Long COVID. Co-production was effective and influenced important aspects of the study.
Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain
Authors: Hall Nicole , James Bradie , Bhuiyan Mohammad Alfrad Nobel , Crane Erin , Falgout Carlie , Murnane Kevin Sean
Published: March 2023

Introduction

Cannabidiol (CBD) is a potential therapeutic for pain management. Yet, there exists a dearth of studies of its tolerability and efficacy, especially in special populations. Former elite athletes are a special population both susceptible to chronic pain and also highly trained and attuned to assess medication tolerability concerns. The purpose of the present open-label pilot study was to assess the tolerability of CBD in this population.

Materials and methods

Retrospective analysis was conducted in deidentified data from 20 individuals who were all previously professional athletes in US/American football, track and field, or basketball, with careers ranging from 4 to 10 years. Participants received topical CBD (10 mg twice daily by controlled dispenser) for chronic pain resulting from acute lower extremity injuries. Assessments of tolerability and secondary analyses of pain, pain-related disability, and activities of daily living were collected by self-report over the 6-week study period. Data were analyzed by descriptive statistics, pairwise t-test, and linear regression.

Results

Seventy percent of participants completed the study. Of the individuals who completed the study, 50% reported minor adverse effects, none of which required medical attention, and 50% did not report any adverse effects. The mostly commonly reported effects were skin dryness (43% of study completers) and skin rash (21% of study completers), which rapidly resolved. There was a significant improvement in self-reported pain levels (intake mean 3.5 ± 0.29; exit mean 1.7 ± 0.23; P < 0.001) and pain-related disability, including family and home responsibilities, life support activities, occupational activities, recreational activities, self-care, sexual function, and social activities (all P < 0.001).

Discussion

To the best of our knowledge, this is the first study to assess CBD treatment in elite athletes, who are disproportionally susceptible to disabling injuries. Topical administration of CBD was tolerated well by this population and resulted in only minor adverse effects. As elite athletes are trained and attuned to assess their own bodies due to their professional lives, this population is likely to detect tolerability concerns. However, this study was limited to a convenience sample and self-reported data. These pilot findings warrant further study of topical CBD in randomized and controlled studies of elite athletes.
Clinical deterioration following arterial switch surgery due to extensive aortopulmonary collaterals, unusual condition but worth considering: case report
Authors: Abdelmohsen Gaser , AlKhushi Naif , Alassiri Abdullah , Al-Radi Osman
Published: March 2023

Background

The occurrence of major aortopulmonary collateral arteries (MAPCAs) is infrequent in patients with D-transposition of great arteries (D-TGA) with intact ventricular septum (IVS). Hemodynamically significant MAPCAs may complicate the postoperative course of these patients after arterial switch operation (ASO).

Case presentation

We present a rare case of neonatal D-TGA-IVS associated with extensive MAPCAs. After the ASO, the patient developed pulmonary hemorrhage, chest wall edema, and deterioration of lung compliance with the need for high-frequency ventilation (HFV). The patient also had a significant capillary leak with skin edema, high chest tube drainage, and high peritoneal drainage. Cardiac catheterization revealed extensive MAPCAs supplying the whole lung segments. After the catheter closure of most of these MAPCAs, the patient had clinical improvement.

Conclusions

Although the occurrence of MAPCAs with D-TGA-IVS is infrequent, clinicians should suspect their presence in cases with unexplained heart failure, pulmonary hemorrhage, or cardiovascular compromise after ASO. Catheter closure of MAPCAs is feasible with an acceptable short-term outcome.
An adaptive linear-mode decomposition for effective separation of linear and nonlinear seismic events, ground roll, and random noise
Authors: Abbasi Salman , Yu Siwei , Akram Jubran , Alam Md Iftekhar , Sarosh Bakhtawer
Published: March 2023

Ground roll and random noise usually mask primary reflections in land seismic data. Different sets of signal processing methods are used to suppress these two noises based on statistical and/or transformation filtering. Among these methods, linear-mode decomposition (LMD) decomposes linear and nonlinear seismic events into amplitude-frequency modulated modes using the Wiener filter. Different combinations of these decomposed linear modes then can be used to represent different seismic events. However, LMD requires predefining the level of decomposition that must be selected carefully to avoid suboptimal binning, which can influence the fidelity of the decomposed seismic modes. To that end, we introduce an adaptive LMD (ALMD) that optimally separates seismic events, ground roll, and random noise. ALMD uses the correlation between the decomposed modes and the input data to determine the decomposition level. Consequently, an optimum decomposition divides the data into linear modes with minimum mixing. In addition, unlike conventional ground roll suppression methods, ALMD does not require estimating the slope or the frequency bandwidth of the ground roll. Moreover, ALMD automates the random noise segregation by separating modes as the signal, noise, and mixed modes, based on the permutation entropy and kurtosis criteria. ALMD iteratively decomposes mixed modes with remnant random noise until a signal or noise criterion is met. Using synthetic and real data examples, we demonstrate that the proposed ALMD is an effective method for separating desired linear and nonlinear events, unwanted ground roll energy, and random noise from the seismic data.
Incentivizing COVID-19 Vaccination in a Polarized and Partisan United States
Authors: Algara Carlos , Simmons Daniel J.
Published: March 2023

Context: As COVID-19 vaccines were rolled out in early 2021, governments at all levels in the United States experienced significant difficulty in consistently and efficiently administering injections in the face of vaccination resistance among a public increasingly politically polarized on vaccination preferences before the beginning of mass vaccinations.

Methods: Using an original conjoint experiment fielded to a nationally representative sample before the mass proliferation of COVID-19 vaccines, the authors examined how different incentives (e.g., employer mandates, state-organized or health care provider–organized vaccination clinics, and financial incentives) affect the public's preference to get vaccinated. They also tested how financial incentive preferences correlated with self-reported vaccination intention using observational data from the June 2021 Kaiser Family Foundation Health Tracking Poll.

Findings: The authors found financial incentives positively influenced vaccine preferences among the mass public and all partisan groups, including Republicans who were initially “unlikely” to be vaccinated. The authors used the observational data to replicate their experimental findings, showing positive financial incentive attitudes positively correlated with self-reported vaccination disclosures.

Conclusions: These results provide support for direct financial incentives, rather than other incentives, as being a valuable tool for policy makers tasked with alleviating vaccination resistance among a US mass public increasingly polarized along partisan lines.
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome
Authors: Moyer Anna J. , Fernandez Fabian-Xosé , Li Yicong , Klinedinst Donna K. , Florea Liliana D. , Kazuki Yasuhiro , Oshimura Mitsuo , Reeves Roger H.
Published: March 2023

Trisomy 21 and mutations in the Sonic hedgehog (SHH) signaling pathway cause overlapping and pleiotropic phenotypes including cerebellar hypoplasia, craniofacial abnormalities, congenital heart defects and Hirschsprung disease. Trisomic cells derived from individuals with Down syndrome possess deficits in SHH signaling, suggesting that overexpression of human chromosome 21 genes may contribute to SHH-associated phenotypes by disrupting normal SHH signaling during development. However, chromosome 21 does not encode any known components of the canonical SHH pathway. Here, we sought to identify chromosome 21 genes that modulate SHH signaling by overexpressing 163 chromosome 21 cDNAs in a series of SHH-responsive mouse cell lines. We confirmed overexpression of trisomic candidate genes using RNA sequencing in the cerebella of Ts65Dn and TcMAC21 mice, model systems for Down syndrome. Our findings indicate that some human chromosome 21 genes, including DYRK1A, upregulate SHH signaling, whereas others, such as HMGN1, inhibit SHH signaling. Individual overexpression of four genes (B3GALT5, ETS2, HMGN1 and MIS18A) inhibits the SHH-dependent proliferation of primary granule cell precursors. Our study prioritizes dosage-sensitive chromosome 21 genes for future mechanistic studies. Identification of the genes that modulate SHH signaling may suggest new therapeutic avenues for ameliorating Down syndrome phenotypes.
Pierwsze stanowisko Stereocaulon pileatum Ach. (Stereocaulaceae, Ascomycotina Licheniasti) na niżu polskim
Authors: Fałtynowicz Wiesław , Wierzchołek Emilia
Published: March 2023

A new locality of rare lichen species, Stereocaulon pileatum, in the Wielkopolska region was found in 2017 in the vicinity of Wieruszów city. The lichen grew massively on small melaphyre stones on the railway embankment over a lenght of almost 2 kilometers. The optimal habitat conditions are confirmed not only by the mass occurrence, but also by the good health of the thallus and the presence of numerous fruiting bodies. It is a species known in Poland from only 15 sites in the mountains. It is under strict legal protection and having the EN category in the “Red List of Polish Lichens”.
Bayesian Contextual Choices Under Imperfect Perception of Attributes
Authors: He Junnan
Published: March 2023

Classic theories show that choices can be represented by a stable utility function when they satisfy consistency axioms, such as transitivity and the independence of irrelevant alternatives. Empirical choice data, however, display several contextual choice effects that violate these axioms. We study a choice model with a fixed underlying utility function and explain contextual choices with a novel type of information friction: the agent’s perception of the options is affected by attribute-specific uncertainty. Under this friction, the agent learns useful information when the agent sees more options. Therefore, the agent chooses contextually, exhibiting intransitivity, joint–separate evaluation reversal, the compromise effect, the phantom decoy effect, the attraction effect, and the similarity effect. Because the uncertainty is attribute-specific and common across alternatives, the classic axioms hold when the alternatives dominate one another in attributes.

This paper was accepted by Dmitri Kuksov, marketing.
Bird flu: should we be concerned?
Authors: Winter George
Published: March 2023

George Winter looks at the recent outbreaks of bird flu that have occurred globally and asks whether this is something to worry about
Exploring Caregiver Perceptions of Post-High School Employment Experiences Among Young Adults With Down Syndrome
Authors: Channell Marie Moore , Loveall Susan J. , Burke Meghan M.
Published: March 2023

This qualitative study explored employment experiences and perceived satisfaction of young adults with Down syndrome (DS) who recently exited high school, as reported by their caregivers (n = 101). We analyzed caregivers' open-ended responses about their young adults' type of employment (n = 52 were employed) and identified themes associated with reported satisfaction (for both employed and unemployed). Natural supports were key to caregiver satisfaction; few opportunities for paid, community-based employment and long waiting lists for formal services were related to caregiver dissatisfaction. Job fit (e.g., hours, responsibilities, location), socialization opportunities, and independence were related to caregiver and perceived young adult (dis)satisfaction. These findings highlight unmet service needs, including assistance with finding a job that is the right fit for the individual with DS.
Portable PIMI polarization imaging device based on automatic polarization recognition
Authors: Zhang Ciqi , Nasir Abbas , Ni Bin , Xu Bin , Xue Lu , Liu Xuefeng , Xiong Jichuan
Published: March 2023

This paper proposes a new portable polarization parametric indirect microscopy imaging without a liquid crystal (LC) retarder. The polarization was modulated by a polarizer automatically rotating when the camera took raw images sequentially. A specific mark tagged the polarization states of each camera’s snapshot in the optical illumination path. A computer vision portable polarization parametric indirect microscopy imagrecognition algorithm was developed to retrieve the unknown polarization states from each raw camera image to ensure that the right polarization modulation states were used in the PIMI processing algorithm. The system’s performance was verified by obtaining PIMI parametric images of human facial skin. The proposed method avoids the error problem caused by the LC modulator and significantly reduces the whole system’s cost.
High-order spatial phase shift method realizes modulation analysis through a single-frame image
Authors: Long Yuliang , Tang Yan , Cheng Xiaolong , Han Chenhaolei , Xiang Qianjin , Yang Yong , Zhao Lixin , Feng Jinhua
Published: March 2023

For the modulation-based structured illumination microscopy system, how to obtain modulation distribution with an image has been a research hotspot. However, the existing frequency-domain single-frame algorithms (mainly including the Fourier transform method, wavelet method, etc.) suffer from different degrees of analytical error due to the loss of high-frequency information. Recently, a modulation-based spatial area phase-shifting method was proposed; it can obtain higher precision by retaining high-frequency information effectively. But for discontinuous (such as step) topography, it would be somewhat smooth. To solve the problem, we propose a high-order spatial phase shift algorithm that realizes robust modulation analysis of a discontinuous surface with a single-frame image. At the same time, this technique proposes a residual optimization strategy, so that it can be applied to the measurement of complex topography, especially discontinuous topography. Simulation and experimental results demonstrate that the proposed method can provide higher-precision measurement.
Two-dimensional imaging under meridional propagation through a dispersive thick lens based on RGB distributions and defocused planes
Authors: Bugoffa Salaheddeen G. , Chatterjee Monish R.
Published: March 2023

In this paper, we consider a 2D polychromatic transparency serving as an object in front of a dispersive thick lens. The RGB based constituent colors are treated in terms of a center wavelength with a spectral spread, thereby enabling the phasor interpretation and tracking along axial image planes. It turns out that any individual color of the input transparency has a unique focal length or image position in the (meridional) observation plane after propagation through the lens. Under dispersion, image characteristics such as foci, axial location, magnification, and amplitude are controlled by narrow sidebands around a monochromatic carrier. The analytical results (derived numerically) are compared with standard non-dispersive imaging. Particular attention is given to the nature of transverse paraxial images in fixed axial planes, whereby defocusing effects due to dispersion are demonstrated in the manner of spherical aberration. Such selective axial focusing of individual wavelengths may find applications in improving the conversion efficiency of solar cells and photodetectors exposed to white light illumination.
Quantitative analysis of rabies virus-based synaptic connectivity tracing
Authors: Tran-Van-Minh Alexandra , Ye Zhiwen , Rancz Ede
Published: March 2023

Monosynaptically restricted rabies viruses have been used for more than a decade for synaptic connectivity tracing. However, the verisimilitude of quantitative conclusions drawn from these experiments is largely unknown. The primary reason is the simple metrics commonly used, which generally disregard the effect of starter cell numbers. Here we present an experimental dataset with a broad range of starter cell numbers and explore their relationship with the number of input cells across the brain using descriptive statistics and modelling. We show that starter cell numbers strongly affect input fraction and convergence index measures, making quantitative comparisons unreliable. Furthermore, we suggest a principled way to analyse rabies derived connectivity data by taking advantage of the starter vs input cell relationship that we describe and validate across independent datasets.
Antimycotic effect of 3-phenyllactic acid produced by probiotic bacterial isolates against Covid-19 associated mucormycosis causing fungi
Authors: Lunavath Ravikumar , Mohammad Saddam Hussain , Bhukya Kiran Kumar , Barigela Anuradha , Banoth Chandrasekhar , Banothu Anil Kumar , Bhukya Bhima
Published: March 2023

The Covid-19 associated mucormycosis (CAM) is an emerging disease affecting immunocompromised patients. Prevention of such infections using probiotics and their metabolites persist as effective therapeutic agents. Therefore, the present study emphasizes on assessment of their efficacy and safety. Samples from different sources like human milk, honey bee intestine, toddy, and dairy milk were collected, screened and characterized for potential probiotic lactic acid bacteria (LAB) and their metabolites to be used as effective antimicrobial agents to curtail CAM. Three isolates were selected based on probiotic properties and characterized as Lactobacillus pentosus BMOBR013, Lactobacillus pentosus BMOBR061 and Pediococcus acidilactici BMOBR041 by 16S rRNA sequencing and MALDI TOF-MS. The antimicrobial activity against standard bacterial pathogens showed ˃9 mm zone of inhibition. Furthermore, the antifungal activity of three isolates was tested against Aspergillus flavus MTCC 2788, Fusarium oxysporum, Candida albicans and Candida tropicalis where the results showed significant inhibition of each fungal strain. Further studies were carried out on lethal fungal pathogens like Rhizopus sp. and two Mucor sp. which are associated with post Covid-19 infection in immunosuppressed diabetic patients. Our studies on CAM inhibitory effect of LAB revealed the efficient inhibition against Rhizopus sp. and two Mucor sp. The cell free supernatants of three LAB showed varied inhibitory activity against these fungi. Following the antimicrobial activity, the antagonistic metabolite 3-Phenyllactic acid (PLA) in culture supernatant was quantified and characterized by HPLC and LC-MS using standard PLA (Sigma Aldrich). The isolate L. pentosus BMOBR013 produced highest PLA (0.441 g/L), followed by P. acidilactici BMOBR041 (0.294 g/L) and L. pentosus BMOBR061 (0.165 g/L). The minimum inhibitory concentration of HPLC eluted PLA on the Rhizopus sp. and two Mucor sp. was found to be 180 mg/ml which was further confirmed by inhibition of total mycelia under live cell imaging microscope.
Diffusion phase-imaging in anisotropic media using non-linear gradients for diffusion encoding
Authors: Wochner Pamela , Schneider Torben , Stockmann Jason , Lee Jack , Sinkus Ralph
Published: March 2023

Diffusion MRI classically uses gradient fields that vary linearly in space to encode the diffusion of water molecules in the signal magnitude by tempering its intensity. In spin ensembles, a presumably equal number of particles move in positive and negative direction, resulting in approximately zero change in net phase. Hence, in classical diffusion weighted MRI with a linear gradient field, the phase does not carry any information as the incoherent motion of the spins only impacts the magnitude of the signal. Conversely, when the linear gradient field is replaced with one that varies quadratically over space, the diffusion of water molecules in anisotropic media does give rise to a change in net phase and preserves large portion of the signal around the saddle point of the gradient field. In this work, the phase evolution of anisotropic fibre phantoms in the presence of quadratic gradient fields was studied in Monte Carlo simulations and diffusion MRI experiments. The simulations confirm the dependence of the phase change on the degree of anisotropy of the media and the diffusion weighting, as predicted by the derived analytic model. First MR experiments show a phase change depending on the diffusion time in an anisotropic synthetic fibre phantom, and approximately zero phase change for the experiment repeated in an isotropic agar phantom. As predicted by the analytic model, an increase of the diffusion time by approximately a factor of two leads to an increase of approximately a factor of two in the signal phase.
CIRO: COVID-19 infection risk ontology
Authors: Egami Shusaku , Yamamoto Yasunori , Ohmukai Ikki , Okumura Takashi
Published: March 2023

Public health authorities perform contact tracing for highly contagious agents to identify close contacts with the infected cases. However, during the pandemic caused by coronavirus disease 2019 (COVID-19), this operation was not employed in countries with high patient volumes. Meanwhile, the Japanese government conducted this operation, thereby contributing to the control of infections, at the cost of arduous manual labor by public health officials. To ease the burden of the officials, this study attempted to automate the assessment of each person’s infection risk through an ontology, called COVID-19 Infection Risk Ontology (CIRO). This ontology expresses infection risks of COVID-19 formulated by the Japanese government, toward automated assessment of infection risks of individuals, using Resource Description Framework (RDF) and SPARQL (SPARQL Protocol and RDF Query Language) queries. For evaluation, we demonstrated that the knowledge graph built could infer the risks, formulated by the government. Moreover, we conducted reasoning experiments to analyze the computational efficiency. The experiments demonstrated usefulness of the knowledge processing, and identified issues left for deployment.
Firefly swarm intelligence based cooperative localization and automatic clustering for indoor FANETs
Authors: Chen Siji , Jiang Bo , Pang Tao , Xu Hong , Gao Mingke , Ding Yan , Wang Xin
Published: March 2023

At present, the applications of multiple unmanned aerial vehicles (UAVs) are becoming more and more widespread, covering many civil and military fields. When performing tasks, UAVs will form a flying ad hoc network (FANET) to communicate to each other. However, subject to high mobility, dynamic topology, and limited energy of FANETs, maintaining stable communication performance is a challenging task. As a potential solution, the clustering routing algorithm divides the entire network into multiple clusters to achieve strong network performance. Meanwhile, the accurate localization of UAV is also strongly required when FANETs are applied in the indoor scenario. In this paper, we propose a firefly swarm intelligence based cooperative localization (FSICL) and automatic clustering (FSIAC) for FANETs. Firstly, we combine the firefly algorithm (FA) and Chan algorithm to better cooperative locate the UAVs. Secondly, we propose the fitness function consisting of link survival probability, node degree-difference, average distance, and residual energy, and take it as the light intensity of the firefly. Thirdly, the FA is put forward for cluster-head (CH) selection and cluster formation. Simulation results indicate that the proposed FSICL algorithm achieves the higher localization accuracy faster, and the FSIAC algorithm achieves the higher stability of clusters, longer link expiration time (LET), and longer node lifetime, all of which improve the communication performance for indoor FANETs.
Generalized statistics: Applications to data inverse problems with outlier-resistance
Authors: dos Santos Lima Gustavo Z. , de Lima João V. T. , de Araújo João M. , Corso Gilberto , da Silva Sérgio Luiz E. F.
Published: March 2023

The conventional approach to data-driven inversion framework is based on Gaussian statistics that presents serious difficulties, especially in the presence of outliers in the measurements. In this work, we present maximum likelihood estimators associated with generalized Gaussian distributions in the context of Rényi, Tsallis and Kaniadakis statistics. In this regard, we analytically analyze the outlier-resistance of each proposal through the so-called influence function. In this way, we formulate inverse problems by constructing objective functions linked to the maximum likelihood estimators. To demonstrate the robustness of the generalized methodologies, we consider an important geophysical inverse problem with high noisy data with spikes. The results reveal that the best data inversion performance occurs when the entropic index from each generalized statistic is associated with objective functions proportional to the inverse of the error amplitude. We argue that in such a limit the three approaches are resistant to outliers and are also equivalent, which suggests a lower computational cost for the inversion process due to the reduction of numerical simulations to be performed and the fast convergence of the optimization process.