bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of the COVID-19 pandemic on the work of social workers
Authors: Schell-Kiehl Ines , Laurens Melissa , Ketelaar Nicole , Sommerfeld Peter , Hess Nadja , Bühler Sarah , Meyer Nikolaus , Franz Sebastian
Published: August 2022

The COVID-19 pandemic has had a major impact on everyone’s life.  Like many other professionals, social workers have been forced to adapt to these new working conditions and new challenges in order to support clients during the pandemic, as new needs have arisen. Together with professional associations from three nations (Germany, Switzerland and the Netherlands), we used a coordinated approach to explore the consequences of the pandemic for social work professionals. This study was conducted during the most severe contact and hygiene restrictions of the second wave of the COVID-19 pandemic in the winter of 2020/2021. The data addresses the changes perceived by social work professionals in relation to their contact and communication with clients, the use of digital technology in the context of work, the professional response in terms of innovation, the working conditions and the psychosocial risks they face.
MethodsCross-sectional data was collected from 7,241 social workers in Germany, Switzerland and the Netherlands through online surveys.
ResultsThe results show an increase in the workload of professional social workers and compounding problems of clients, together with a negative impact of the COVID-19 pandemic on communication and contact with clients. All of this takes place within the framework of changing working conditions and contexts. Our data shows that the use of digital technologies does not cause bigger problems for most of the participating social workers. It should in fact be noted that professionals have many positive associations with the use of digital technology in general.
ConclusionsThere are both remarkable and alarming results concerning the mental health of social workers and their working conditions, as well as the position of the social work profession in general.
SISTEM PAKAR UNTUK MENDIAGNOSA PENYAKIT SISTEM SARAF PUSAT PADA MANUSIA BERBASIS ANDROID DENGAN MENGGUNAKAN METODE FORWARD CHAINING
Authors: Masrukhan Afit
Published: August 2022

Dengankemajuanteknologisaatini,pengetahuandokterdapatdiimplementasikan menjadi sebuah sistem yang disebut sistem pakar. Aplikasisistem pakar ini dibuat untuk mendiagnosa penyakit sistem saraf pusat denganberbasis android. Sistem saraf pusat adalah sistem tubuh yang menerima danmemproses semua informasi dari seluruh bagian tubuh. Sistem saraf pusat sangatpentingbagi kelangsungan hidup manusia. Tahap pengembangan aplikasi meliputi analisis, perancangan sistem,implementasi, dan pengujian. Sistem pakar untuk mendiagnosa penyakit sistemsaraf pusat pada manusia berbasis android dengan menggunakan metode forwardchaining dibangun menggunakan bahasa pemrograman java dengan IDE AndroidStudio.Metodepengumpulandatadenganmenggunakanmetodeobservasi,wawancara,dan studi pustaka. Hasil penelitian ini berupa program aplikasi sistem pakar yang mampumendiagnosa penyakit sistem saraf pusat sebanyak 10 jenis penyakit. Keluaransistem berupa hasil penelusuran penyakit saraf pusat yang diperoleh berdasarkangejala yang diinputkan user. Pada uji coba blackbox hasil yang didapat adalahsemuafungsiaplikasiberhasilberjalandenganbaikdanpadaujicobakepenggunaaplikasi dinilai baikdari sisi tampilanmaupun informasi.
Pengelompokan Kabupaten Dan Kota Di Provinsi Jawa Timur Berdasarkan Tingkat Kesejahteraan Dengan Metode K-Means Dan Density-Based Spatial Clustering Of Applications With Noise
Authors: Jatipaningrum Maria Titah , Azhari Suci Eka , Suryowati Kris
Published: August 2022

East Java Province has an uneven welfare condition. The uneven welfare conditions are indicated by a large number of poor people in East Java and the rate of economic growth which has decreased in 2020, reaching -2.39% due to the impact of the pandemic. Welfare can be measured through several indicators, while the indicators used to classify districts and cities in East Java among others include population density, labor force, labor force participation rate, and open unemployment rate. Thus, to find out the grouping of regencies and cities in East Java Province based on the level of welfare, grouping was carried out using the K-Means and Density-Based Spatial Clustering of Applications with Noise (DBSCAN) methods. For each of the two methods, distance calculations are performed using the Euclidean and Manhattan distances. Each distance was tested for validity using the Davies-Bouldin Index (DBI), C-Index, and Dunn Index. This study concludes that the best method is the DBSCAN method using Manhattan distance with MinPts = 2 and eps = 4 which has the smallest DBI value of 0.284, with 2 clusters formed and 5 noise. Cluster 1 consists of 26 regencies, cluster 2 consists of 7 cities, and noise consist of 5 regencies and cities. Keywords: Welfare, K-Means, DBSCAN, Euclidean Distance, Manhattan Distance.
Understanding radio art reception
Authors: Soto-Sanfiel María T. , Freeman Bradley C. , Angulo-Brunet Ariadna
Published: August 2022

Radio art is understood as radio made by artists. The term is typically applied to sound-based artifacts produced and broadcast by means of the creative use of radio media affordances, infrastructure, and technologies. Radio art is known as any sound work conceived to expand the creative and aesthetic possibilities of the medium through the use of the elements of radiophonic language (voice, words, music, sound effects, and silence) with the intention to produce aesthetic messages and to move radio listeners. This study introduces radio art reception as a subject of scientific scrutiny. It proposes a model of radio art processing that includes involvement, art reception, and positive emotions as predictors of the willingness to listen to such works. After listening to each of two pieces of radio art, 126 Singaporean undergraduate communication students (MAge = 22.7, SD = 1.7) completed a questionnaire measuring involvement, art reception, perceived emotions, and willingness to listen to another radio art feature. The main results confirm our model of radio art reception: involvement predicts the audience’s cognitive stimulation generated by radio art, their artistic evaluation, and the positive attraction experienced by audiences towards them. The positive emotions experienced during consumption have a direct effect on the attraction towards radio art. Moreover, the specific radio art content affects the audiences’ responses. These results allow us to understand psychological responses to sound art. The hope is to attract the attention of communication and art researchers and invite them to deepen the existing knowledge about artistic sound through empirical studies, since debates about radio art and sound works are almost lacking from scientific literature.
MULTICULTURALISM IN EDUCATION: HISTORY AND MODERN TRENDS
Authors: Hlukhota Vitalii
Published: August 2022

The study of multiculturalism in the modern world and modern conditions is an urgent scientific and pedagogical problem. The influence of integration processes leads to a change of opinion about the need for tolerant relations between different cultures in relation to each other. Currently, in the context of the development of international relations, cultural exchange is taking place at the personal, national, and international levels. Therefore, in education, there is a need for a culture of communication, and dialogue of cultures between different countries. This process, together with the development of national culture, enriches both dominant and small cultures. The closedness of individual ethnic communities and conflicts on national and religious grounds is the result of a complex set of social factors. One of them is ignoring the factors of multiculturalism and polyethnicity in education and training in a multinational community. Accounting for multiculturalism and polyethnicity is becoming a pedagogical priority for world civilization and individual states. Its observance is a necessary condition for the democratization of public life. Conditions of effective education are largely outside of pedagogy and depend on the influence of sociopolitical institutions.The article reveals the peculiarities of the emergence and development of ideas of multiculturalism in education. The analysis of the scientific literature is carried out in order to systematize the data on the views of scientists on the need for multicultural education in the educational process of different historical periods. Clear chronological data on the emergence of the definition of multicultural education in the scientific community. The peculiarities of monocultural education as a counterbalance to multiculturalism in education are studied. The modern tendencies in multicultural education and the necessity of its introduction in the modern educational environment are determined.

Keywords: culture; intercultural interaction; multiculturalism; multicultural education; monocultural education; multiculturalism; assimilation of cultures; “melting furnace”.
PENGARUH PUPUK ORGANIK CAIR AIR LIMBAH BUDIDAYA LELE TERHADAP PERTUMBUHAN DAN HASIL TANAMAN MENTIMUN (Cucumis sativus L.)
Authors: Henggra Muhammad , Murnita Murnita , Afrida Afrida
Published: August 2022

Penelitian pengaruh pemberian pupuk organik cair (POC) air limbah budidaya lele terhadap pertumbuhan dan hasil tanaman mentimun (Cucumis sativus L.) telah dilaksanakan di daerah Jorong III Sangkir, Kecamatan Lubuk Basung, Kabupaten Agam. Dimulai dari bulan Mei sampai dengan Juli 2021. Penelitian bertujuan untuk mendapatkan konsentrasi POC air limbah budidaya lele yang terbaik untuk pertumbuhan dan hasil tanaman mentimun (Cucumis sativus L.). Percobaan menggunakan Rancangan Acak Kelompok (RAK) dengan 5 perlakuan dan 4 kelompok, sehingga terdapat 20 satuan percobaan. Setiap satuan percobaan (petakan) terdapat 6 tanaman. Perlakuan yang diberikan adalah beberapa konsentrasi POC air limbah budidaya lele, yaitu : A = 0 % (0 ml/l air), B = 10 % (10 ml/l air), C = 20 % (200 ml/l air), D = 30 % (300 ml/l air), dan E = 40 % (400 ml/l air). Data-data yang diperoleh dianalisis secara statistik dengan uji F, dilanjutkan dengan uji DNMRT pada taraf nyata 5%. Hasil penelitian menunjukkan bahwa pemberian konsentrasi POC air limbah budidaya lele berpengaruh sangat berbeda nyata pada ruas tanaman, dan untuk panjang tanaman dengan jumlah bunga betina memperlihatkan pengaruh berbeda nyata, sedangkan untuk umur panen, diameter buah panjang buah, jumlah buah pertanaman, jumlah buat perpetak, bobot buah pertanaman, bobot buah perpetak memperlihatkan pengaruh berbeda tidak nyata. Hasil penelitian menunjukkan bahwa belum diperoleh konsentrasi yang tepat untuk pertumbuhan dan hasil mentimun yang optimal, berdasarkan potensi hasil. Maka disarankan untuk penelitian lanjutan menggunakan konsentrasi POC air limbah budidaya lele dengan konsentrasi yang lebih besar dari 40 %.

Kata Kunci: POC air limbah budidaya lele, pertumbuhan, hasil, mentimun
Delone and McLean Models for measuring the success of Flores University e-learning information system
Authors:   Universitas Flores, Tute Kristianus Jago , Londa Maria Adelvin ,   Universitas Flores, Mude Anastasia ,   Universitas Flores
Published: August 2022

The University of Flores first conducted E-Learning learning amid the covid 19 pandemic, the problem faced was that most of the lecturers at the University of Flores did not understand E-learning by using information technology. The Faculty of Information Technology facilitated all faculties at the university to conduct e-training. E-Learning, in the learning process. The aim is to measure success in implementing the University of Flores E-Learning information system. The model in this study is the Delone and Mclean model to measure success with six dimensions, namely, system quality, information quality, users, service quality, user satisfaction, net benefits. The method in this research is observation, a survey using questionnaires in the form of a Likert scale, and a literature study. The data analysis technique used simple linear regression. The results showed that the Delone and Mclean models were very well used to measure the success of using e-learning. The conclusion is that the quality of information on the use percentage of 34.4%, the quality of service they use of 33.8%, the quality of the system on the satisfaction of the users is 38.6%, and the quality of the services on the satisfaction of the users 34,5%, the users on the satisfaction of the users 43,4%, use of net benefits is 58.7% and user satisfaction of net benefits is 48.8%. The higher the value of these variables, the higher the success rate of information systems using E-learning at universities will be.
Number marking in Dagara and French
Authors: Hien Alain N.
Published: August 2022

This paper examines how number is marked in Dagara (Gur, Nige-Congo) and French. It argues that number occupies a syntactic position in Dagara and French and that the difference between the two languages resides in the syntactic operation through which number is marked. Following previous studies, the paper mentions that the status of number in Dagara and French can be assumed to be similar to that in English and that the difference among the three languages is the operation involved in number marking and the syntactic position of number in the structure of nominal phrases. This difference is responsible for the morphological manifestation of number on all the constituents of a nominal phrase in French but on only one constituent in Dagara and English. Besides, the paper claims that the difference between Dagara and English in number marking is in the syntactic position of number and that this difference explains why the plural marker is always on nouns but not on adjectives in English. In contrast, nouns do not take the plural marker in the presence of an adjective in Dagara.
ANALYSIS OF ANAPHORA AND ITS THEMATIC ROLES ON A NEWS ITEM
Authors: Sri Widianingsih Ayang Winda , Shadam Hussaeni Handi Pratama
Published: August 2022

Nowadays, the issue about muslim population is being discussed and Indonesia is one of the world’s largest Muslim population. At the same time, Indonesia has released film “Rahmat Islam Nusantara” which was written in detail in online media and widely consumed by the public. Based on the excitement, this study focused on the analysis of anaphora to know the reference in every antecedent and continued with thematic roles theory to know the theme of its antecedent on news item to make the news being clear. The study was formulated to answer research questions (1) what does anaphora refer to?. (2) what is thematic roles of that anaphora?. This study employed the qualitative method as research design. The researcher picked archive document analysis research procedure in breaking down the information. “English Syntax : A grammar for English Language Professionals” by Roderick A Jacobs (1995) and “English syntax” by Aarts (2001) were used as the main reference. The analysis showed that there are 31 anaphors found in this article. An anaphora can be found in the same clause with its antecedent whereas thematic roles found is undergoer or theme. Theme role agents create states of affairs, whereas thematic role experiencers have sensory, cognitive, and emotional experiences. Thus, the article demonstrates that what is being said is based on the writer/emotional speaker's experience and his subjective opinion about the problem.
Pelatihan Media Pembelajaran guna Meningkatkan Kompetensi Mengajar Guru di SMP Negeri 3 Kutorejo
Authors: Anwar Rosyida Nurul , Agusrini Putri Ayu , Aulia Salsabila Tazkia
Published: August 2022

The development of science and technology in the world of education requires every individual to innovate. A teacher is a profession that requires particular skills in teaching students in schools. Developing skills in teaching is a must for teachers to get results that contribute to improving the quality of education. This service aims to provide understanding in the form of learning media training for teachers at SMP Negeri 3 Kutorejo. The implementation of community service activities regarding learning media training got satisfactory results because as many as 87% of teachers felt the benefits of increasing knowledge in teaching with learning media.
Peningkatan Pemahaman Remaja Karang Taruna Melalui Sosialisasi Buku Saku Fiqih
Authors: Wardani Dian Kusuma , Umardiyah Fitri , Prihatiningtyas Suci , Husna Asiyah Lulu'ul
Published: August 2022

The Fiqh Pocket Book Socialization activity in the context of increasing understanding of fiqh lessons is an activity aimed at youth youth groups in Mojokambang village so that they obtain information, so that awareness arises, accepts and ultimately uses the information to add insight related to fiqh material. The implementation method includes observation, asking permission from partner villages, planning stage, implementation stage (socialization), training and monitoring and evaluation stage. This socialization contains the delivery of material on the importance of learning fiqh for Muslims as a guide to living in accordance with the Qur'an and Hadith as a provision for daily life in facing the challenges of the times. After the socialization, a fiqh discussion seminar was held. The results of the socialization of the fiqh pocket book showed that the participant's response to the material presented was in good category with an average percentage of 89%, the participant's response to the demonstration of fiqh material practice was in good category with an average percentage of 89%. Participants' responses to the media used in the process of learning fiqh material were categorized as good with an average percentage of 80%. The participant's response to the socialization instructor was categorized as good with an average percentage of 79%. So overall the participants gave a positive response to the socialization activity of providing fiqh material as a means to increase insight and knowledge and understanding related to fiqh learning for youth youth in Mojokambang village.
ЕКОЛОГІЧНІ ТЕНДЕНЦІЇ ФІСКАЛЬНОЇ ПОЛІТИКИ УКРАЇНИ ТА КРАЇН ЄВРОПЕЙСЬКОГО СОЮЗУ
Authors: Марченко Людмила
Published: August 2022

У статті досліджено європейські пріоритети екологічного оподаткування у фіскальній політиці держави. Висвітлено сутнісні та нормативні детермінанти адміністрування екологічного податку в українській фіскальній практиці. Наведено класифікаційні групи залежно від об’єкту екологічного оподаткування у країнах Європейського Союзу. Виявлено, що податки на забруднення виконують в першу чергу регулюючу функцію, а також соціальну та фіскальну. Систематизовано основні форми використання податкових інструментів в екологічних цілях. Констатовано, що пріоритетна роль державної фіскальної та соціально-екологічної політики відноситься механізмам акумулювання та розподілу податкових надходжень. Незважаючи на своє базове регулятивне призначення, екологічний податок слугує перспективним джерелом мобілізації надходжень до бюджету у більшості країн Європейського Союзу. Акцентовано на незначних показниках частки екологічного податку у податкових надходженнях Зведеного бюджету України. Внаслідок візуалізації екологічної кривої та моніторингу тенденцій оподаткування енергії, ресурсів, транспорту та джерел забруднення природнього середовища в Європейському Союзі було сформовано орієнтири удосконалення екологічного оподаткування у прагматизмі здійснення фіскальної політики України.
ОСОБЛИВОСТІ ОПОДАТКУВАННЯ ЗОВНІШНЬОЕКОНОМІЧНИХ ОПЕРАЦІЙ ПІД ЧАС ВОЄННОГО СТАНУ В УКРАЇНІ
Authors: Чиркова Юлія , Ткачук Богдана
Published: August 2022

Під час воєнного стану кардинальних змін зазнали усі соціально-економічні сфери функціонування та розвитку нашої держави, зокрема й система податкового управління. У статті розкрито основні зміни в процесі стягнення податків в умовах здійснення зовнішньоекономічних операцій між суб’єктами господарювання України та країн-партнерів в умовах воєнного стану, впровадженого внаслідок повномасштабної війни російської федерації проти України, розпочатої 24 лютого 2022 року. Досліджено особливості внутрішньодержавних новацій щодо особливостей імплементації імпортно-експортних операцій для окремих суб’єктів господарювання. Систематизовано пільги, в тому числі й податкові, впроваджені різними країнами щодо імпорту українських товарів та послуг. Також в цілому розкрито перспективи повоєнної відбудови України, що були окреслені на Міжнародній конференції з питань відновлення України у м. Лугано (Швейцарія), зокрема ті, що власне забезпечуватимуться за рахунок реформування податкових механізмів у нашій державі. Охарактеризовано важливість посилення пільг на ключові українські експортні товари, що необхідні для забезпечення нормального й стабільного життя громадян інших держав. Аналізуючи імпорт, розглянуто зміни, що поетапно вносились у Податковий Кодекс України щодо відповідних операцій українських суб’єктів господарювання. На основі зазначених даних показано вплив проведених заходів на економіку держави в час війни та наголошено на важливості реформування оподаткування зовнішньоекономічної сфери в Україні.
СТАНДАРТИЗАЦІЯ ВМІСТУ ПОТЕНЦІЙНО ТОКСИЧНИХ ЕЛЕМЕНТІВ У РИБІ ТА МОРЕПРОДУКТАХ: ПОРІВНЯЛЬНИЙ АНАЛІЗ МІЖНАРОДНИХ СТАНДАРТІВ ТА ДСТУ
Authors: Лихолат Олена , Вишнікіна Олена , Сабіров Олександр
Published: August 2022

У статті розглянута проблема забезпечення населення України якісною та безпечною рибною продукцією. Проведений порівняльний аналіз вимог щодо вмісту важких металів в Регламенті Комісії ЄС, Державних стандартах КНР та національних стандартах України. Встановлені відмінності вимог максимально допустимих рівнів основних забруднювачів, а саме ртуті та миш’яку, у рибі та морепродуктах, а також об’єктах, які підлягають обов’язковому контролю на їх вміст у зазначених технічних регламентах. Зроблений висновок щодо необхідності якнайшвидшої імплементації міжнародних вимог з безпеки харчової продукції в державні стандарти України, редагування стандартів, зважаючи на ризики для здоров’я споживачів контамінації сумішами потенційно токсичних елементів; посилення контролю за дотриманням технічних регламентів при використанні риби та морепродуктів, в тому числі, в закладах ресторанного господарства.
Szkoła podstawowa bez Innego. Od (braku) wielokulturowości w szkolnej edukacji literackiej i kulturowej ku praktycznym rozwiązaniom
Authors: Miłko Marcin
Published: August 2022

Wielokulturowość jest jednym z  istotniejszych elementów kształcenia humanistycznego, szczególnie polonistycznego, na wszystkich etapach szkolnej edukacji. Lektury obowiązkowe i dodatkowe omawiane w trakcie lekcji języka polskiego po[1]winny poruszać ten istotny temat, aby wpływać na wartości oraz postawy dzieci i  młodzieży. W  artykule poddano analizie listę lektur z  podstawy programowej kształcenia ogólnego dla klas IV–VIII szkoły podstawowej z 2017 roku i wykazano, że w wybranych do omówienia książkach występują nielicznie wątki dotyczące innych kultur. W związku z wnioskami wypływającymi z analizy dokumentu oświatowego zostały zaproponowane teksty literackie oraz związane z  nimi działania metodyczne, które nauczyciele mogą wykorzystać w trakcie lekcji języka polskiego w celu kształcenia kompetencji międzykulturowych.
ПСИХОДІАГНОСТИКА ОСОБЛИВОСТЕЙ РОБОТИ СКОРБОТИ СПРЯМОВАНОЇ НА ОПРАЦЮВАННЯ ПСИХОТРАВМ ОТРИМАНИХ ПІД ЧАС ВІЙНИ ЦИВІЛЬНИМ НАСЕЛЕННЯМ
Authors: Плескач Богдан
Published: August 2022

Вивчення існуючих методик показало, що психодіагностика особливостей роботи скорботи здійснюється в основному при роботі з пролонгованим горюванням після втрати близької людини. Теоретичний аналіз показує, що модель роботи скорботи при втраті близької людини застосовується і для пояснення процесу опрацювання інших психотравм. Проте, психодіагностичних методик, які вивчають психологічний процес опрацювання широкого спектру психотравм (втрата здоров’я, соціального статусу, житла, сексуальне насилля, переселення, розлука з близькими тощо) – відсутні. В роботі презентовано три методики, які були адаптовані до означених задач: модифікований Hogan grief reaction checklist (переклад на український В. Зливков, С. Лукомська); авторська Шкала відреагування травматичної події на рівні процесів уяви; авторська Анкета особливостей реакції на травму. Подаються результати емпіричного дослідження надійності та валідності зазначених методик.
Cancer-related thrombosis among older patients in a hospital in Vietnam: A retrospective study
Authors: Than The Ha Ngoc , Nguyen Lan Phuong , Nguyen Tien Ngoc Hoanh My , Pham Tai Huy Kien , Nguyen Tran To Tran , Vo Nhan Thanh
Published: August 2022

Venous thromboembolism (VTE), a highly prevalent complication in cancer patients, causes prolonged hospitalization and mortality. This study aimed to investigate the characteristics of VTE in older patients with cancer.

This was a retrospective study. Data were extracted from electronic medical records at the Geriatrics-Palliative Care Department of University Medical Center Ho Chi Minh City. Inclusion criteria included: aged ≥ 60 years, confirmed or newly diagnosed with cancer, and new VTE diagnosis. Exclusion criteria included lacking any information on demographics, laboratories, or treatments. Pulmonary embolism (PE) was confirmed using chest computerized tomography scans, while deep vein thrombosis (DVT), and other types of venous thrombosis were confirmed based on a doppler or abdominal ultrasound. Data were analyzed using Stata 15.0, with p <0.05 signifying statistical significance.

Data of 151 patients were extracted from 1170 medical records (median age: 67, range 60 to 89 years). The three most frequent types of VTE were portal vein thrombosis (48.3%), PE (30.5%), and DVT (29.1%). Stage IV cancer was found in 74.2% of VTE patients. Leg pain was presented in 59.1% of the patients with DVT, and dyspnea was confirmed in 80.4% of the patients with PE. Anticoagulant therapy was the most common treatment for VTE (33.8%) and no major bleeding was recorded.

VTE was highly common among older patients with advanced cancer. Leg pain was an indicator of DVT and dyspnea was a warning sign of PE in older patients with cancer. No major bleeding was recorded in those receiving anticoagulants.
Facilitation of the Dynamics of Social Interaction Skills Development in Preschool Children with Autism Spectrum Disorder
Authors: Vasina Veronika V
Published: August 2022

The increase in the number of children with autism spectrum disorders has exacerbated the problem of improving (facilitating) social interaction skills in preschoolers. This category of children is characterized by a combination of qualitative disorders, where one of the main manifestations is difficulties in verbal and social behavior. The aim is to study the dynamics of the development of social interaction skills in preschoolers with autism spectrum disorders, depending on gender and age, to identify points of facilitation, to give recommendations. On the basis of ontological and behavioral approaches, theoretical methods of analysis of philosophical, psychological and pedagogical literature are used, among the empirical methods are the Sundberg method VB-MAPP (2008), observations, qualitative analysis, Student's T-criterion. A longitudinal study (2018-2022) of 54 preschoolers with ASD from different kindergartens in Kazan is presented. The dynamics of the development of skills of children with ASD in longitudinal study is minimal, contradictory, depends not on age, but on the complexity of the defect.
Larger Groups, Smaller Enantioselectivity? Two Anthracene-Containing, Pyridino-Crown Ether-Based Fluorescent Sensor Molecules
Authors: Szemenyei Balázs , Firisz Marianna , Baranyai Péter , Bagi Péter , Drahos László , Móczár Ildikó , Huszthy Péter
Published: August 2022

(R,R)- and (S,S)-enantiomers of anthracene-containing pyridino-18-crown-6 ether having tert-butyl groups at the stereogenic centers were prepared with the aim of achieving higher enantioselectivity than for the reported (S,S)-analogue having isobutyl groups. The enantiomeric recognition abilities of the new sensor molecules toward chiral protonated primary amines and amino acid esters were studied in acetonitrile by UV–vis and fluorescence spectroscopies. The pKa values of these pyridino-crown ethers and their reported (S,S)-analogues having methyl or isobutyl groups have also been determined in acetonitrile.
Cuidados de enfermagem a pacientes acometidos com infarto agudo do miocárdio
Authors: Silva Whesley Pereira , Barbosa Italo Everton Bezerra , Mota Breno de Souza , Melo Fabrício de Souza , Rodrigues Antônio José Paulo da Silva , Verdi Letícia Hessel Motta , Silva Marta Adriana Pereira da , Santos Paula Juliana dos , Sá Lais Cristina Nunes , Neves Daiana Carla Marques das
Published: August 2022

Dentre as diversas doenças cardiovasculares, destaca-se o Infarto Agudo do Miocárdio que é uma lesão que acomete o músculo cardíaco, ocasionada pela diminuição inadequada da oferta de nutrientes e oxigênio, induzindo a obstrução do fluxo sanguíneo, podendo desenvolver necrose tecidual. O enfermeiro é o profissional qualificado para realização de diversas ações e cuidados assistenciais ao paciente com IAM. Logo, a pesquisa visa descrever os fatores associados e os cuidados de enfermagem ao paciente acometido com IAM. Trata-se de um estudo exploratório, qualitativo e descritivo, usando como técnica a Revisão Integrativa da Literatura e a estratégia de PICO para formação da pergunta problema. A pesquisa foi elaborada entre os meses de março e maio de 2022, nas bases de dados: BDENF, MEDLINE e LILACS. A busca foi realizada por meio da junção de três descritores, cruzados com o operador booleano “AND”: “Infarto do Miocárdio, Doenças Cardiovasculares, Cuidados de Enfermagem”. Foram encontrados 1.393 artigos no total. Ao adicionar os critérios de inclusão e exclusão esse número reduziu para 51. Após análise, 13 pesquisas foram selecionadas. O principal cuidado ao paciente acometido por IAM é o conforto no leito de UTI, reduzindo os níveis de ansiedade desse paciente frente a um quadro grave. As ações realizadas pelo enfermeiro são de extrema importância frente aos cuidados assistenciais direcionados ao paciente com IAM. Diante disso, necessita-se que a pesquisa possa servir de subsídio para nortear outras publicações, colaborando para disseminação do conhecimento científico.
Gravidez na adolescência: um olhar sob a ótica psicossocial
Authors: Ribeiro Milena Cristina Cabral , Alves Raphaela Nunes
Published: August 2022

Objetivos: analisar os aspectos psicossociais em adolescentes grávidas; descrever os sentimentos e expectativas vivenciadas; caracterizar os fatores psicossociais enfrentados. Metodologia: estudo exploratório-descritivo, com abordagem qualitativa, desenvolvido numa unidade de atenção primária do estado do Rio de Janeiro, em Nova Iguaçu. As participantes do estudo foram adolescentes que realizam pré-natal na unidade. Critérios de inclusão: estar vinculada a Unidade e possuir idades entre 12 e 19 anos. Critérios de exclusão: (a) aquelas que não estivessem acompanhadas por um responsável legal para assinatura do Termo de Consentimento Livre e Esclarecido (TCLE); (b) possuíssem problema físico ou mental que impossibilitasse sua participação; (c) possuíssem idade menor que 12 anos. Foram respeitados todos os requisitos éticos e legais propostos pela Resolução 466/12 CNS. A coleta de dados foi realizada na instituição, tendo como instrumento de coleta a entrevista semiestruturada e observação participante. Para análise de dados foi utilizada análise de conteúdo de Bardin. Resultados: o ato sexual desprevenido não é o único fator responsável para ocorrência da concepção precoce; a deficiência no conhecimento, falta de acesso à informação, renda, idade da menarca e sexarca, histórico familiar, escolaridade, também contribuem significativamente para o desfecho deste cenário. Conclusão: é necessário o desenvolvimento e aprimoramento de programas de educação em saúde que deem voz as necessidades, singularidades e expectativas do grupo em questão; que abordem contextos além da anatomia e fisiologia reprodutiva, sobretudo, que considerem as vivências emocionais e socioculturais da sociedade, contribuindo para a minimização da invisibilidade e instigando avanços na saúde pública.
Changes in fish assemblages after marine heatwave events in West Hawai‘i Island
Authors: Olsen AY , Larson S , Padilla-Gamiño JL , Klinger T
Published: August 2022

Marine heatwaves are prolonged events of anomalously warm water that affect diverse marine habitats and their associated biota. Evidence shows that anthropogenic climate change is increasing the frequency and duration of marine heatwaves and that coral reef systems are sensitive to the thermal stress imposed by these heatwaves. In this study, we examined fish community response to consecutive marine heatwaves (2014-2015) by analyzing changes in fish assemblages in Hawai‘i over 11 yr (2009-2019). Subtidal video survey data were collected in 3 areas on the west side of the Big Island of Hawai‘i. Fish were counted and identified to species or genus, then assigned to one of 7 functional groups: predators, secondary consumers, planktivores, corallivores, scrapers, grazers or browsers. Our study revealed 4 key findings. We show that all fish assemblages changed significantly in each area after the marine heatwaves. Across all 3 areas, the 3 most abundant functional groups (planktivores, grazers and secondary consumers) drove the observed changes in the community. Following the marine heatwaves, fish abundance increased in 2 areas with fewer fishing regulations. In the most protected area, fish abundance remained high and diversity indices were significantly higher post-marine heatwaves. Our results support the hypothesis that marine heatwaves can cause shifts in fish assemblages and that the precise nature of these shifts can vary over relatively short spatial scales that may coincide with scales of management.
A SURVEY ON DETECTION METHODS USING DATA MINING
Authors: Baby T , Nirmaladevi Dr. P.
Published: August 2022

Extraction of information from huge quantities of data is known as data mining. In other words, data mining is the process of mining knowledge from data. It is a multi-disciplinary skill to extract information and evaluate future events probability. The recent applications of Data Mining are marketing, fraud detection, scientific discovery, etc. All of these will detect previously unknown although acceptable relationships among the data which are already hidden, unsuspected, and previously unknown. Nowadays, it is mainly used in information security. The significance of data mining in malware detection, intrusion detection, and fraud detection are explored in this research study
THE BASIC LAWS OF TRADE
Authors: Rahman Abdurrahman Arum
Published: August 2022

According to the theory of comparative advantage of David Ricardo and Ohlin-Heckscher, countries with different resources and technology will benefit from trading, regardless of competitiveness. This is the core theory in international trade. However, in the real world, this theory does not always work. Some countries may gain from trading, some may not, and some may even lose. The total gain for all parties is also not optimal. We hypothesize another basic law that could fix this problem. This law is more basic than the comparative advantage. The theory of comparative advantage stands on this basic law. When the basic law is met, then comparative advantage theory works well, i.e. countries with different resources and technology will benefit from trading, regardless of competitiveness and cost. We made a simple and common simulation 2x2 and 5x20 model to demonstrate the workability of this hypothesis.
ESBSD: An Essay on the New Exponential Smoothing Methodology Applied to the Projection of the Population of Belo Horizonte
Authors: Pereira Daniel Henrique
Published: August 2022

Population projection is essential for the public and private sectors because it is possible to estimate the number of people that will be served by infrastructure works and services. In this paper, a mathematical model based on alternative exponential smoothing was presented, tested, and approved in thousands of real case studies in different fields of study. Using this method and after obtaining data from previous years, projections were raised for the years 2022 to 2034 for the city of Belo Horizonte, Minas Gerais, Brazil.
The survivor strain: isolation and characterization of Phormidium yuhuli AB48, a filamentous phototactic cyanobacterium with biotechnological potential
Authors: Koch Moritz , Noonan Avery J. C. , Qiu Yilin , Dofher Kalen , Kieft Brandon , Mottahedeh Soheyl , Shastri Manisha , Hallam Steven J.
Published: August 2022

Despite their recognized potential, current applications of cyanobacteria as microbial cell factories remain in early stages of development. This is partly due to the fact that engineered strains are often difficult to grow at scale. This technical challenge contrasts with the dense and highly productive cyanobacteria populations thriving in many natural environments. It has been proposed that the selection of strains pre-adapted for growth in industrial photobioreactors could enable more productive cultivation outcomes. Here, we described the initial morphological, physiological, and genomic characterization of Phormidium yuhuli AB48 isolated from an industrial photobioreactor environment. P. yuhuli AB48 is a filamentous phototactic cyanobacterium with a growth rate comparable to Synechocystis sp. PCC 6803. The isolate forms dense biofilms under high salinity and alkaline conditions and manifests a similar nutrient profile to Arthrospira platensis (Spirulina). We sequenced, assembled, and analyzed the P. yuhuli AB48 genome, the first closed circular isolate reference genome for a member of the Phormidium genus. We then used cultivation experiments in combination with proteomics and metabolomics to investigate growth characteristics and phenotypes related to industrial scale cultivation, including nitrogen and carbon utilization, salinity, and pH acclimation, as well as antibiotic resistance. These analyses provide insight into the biological mechanisms behind the desirable growth properties manifested by P. yuhuli AB48 and position it as a promising microbial cell factory for industrial-scale bioproduction[221, 1631].
Ultrasound combined with glial cell line-derived neurotrophic factor-loaded microbubbles for the targeted treatment of drug addiction
Authors: Wang Feng , Wu Hongwei , Hu Azhen , Dong Lei , Lin Xiaoxia , Li Menghao , Wang Yongling , Li Wenjun , Chang Liansheng , Chang Yuqiao , Liu Hanqing , Shi Yu , Li Nana
Published: August 2022

Drug addiction is a serious problem globally, recently exacerbated by the COVID-19 pandemic. Glial cell-derived neurotrophic factor (GDNF) is considered a potentially effective strategy for the treatment of addiction. Previous animal experiments have proven that GDNF has a good therapeutic effect on drug addiction, but its clinical application is limited due to its poor blood-brain barrier (BBB) permeability. Low-frequency focused ultrasound, combined with microbubbles, is a non-invasive and reversible technique for locally-targeted BBB opening. In the present study, magnetic resonance imaging-guided low-frequency focused ultrasound, combined with GDNF microbubbles, was used to target BBB opening in the ventral tegmental area (VTA) region. The effects of GDNF on morphine-induced conditioned place preference (CPP) and acute withdrawal symptoms in rats after a partially opened BBB were evaluated by behavioral observation. Western blot was used to detect changes in tyrosine hydroxylase (TH) expression levels in the VTA region after different treatments, and high performance liquid chromatography was used to detect the changes in monoamine neurotransmitter content. The results showed that ultrasound combined with GDNF microbubbles targeted and opened the BBB in the VTA region, and significantly increased GDNF content, destroyed morphine-induced CPP, and reduced the withdrawal symptoms of morphine addiction in rats. Furthermore, the up-regulation of TH expression and the increase of norepinephrine and dopamine content induced by morphine were significantly reversed, and the increase of 5-hydroxytryptamine content was partially reversed. Therefore, ultrasound combined with GDNF microbubbles to target and open the BBB can effectively increase the content of central GDNF, thus playing a therapeutic role in morphine addiction. Our study provides a new approach to locally open the BBB and target delivery of neurotrophic factors, such as GDNF, to treat brain diseases like addiction.
Recent advances in the development of biocompatible nanocarriers and their cancer cell targeting efficiency in photodynamic therapy
Authors: Dhilip Kumar Sathish Sundar , Abrahamse Heidi
Published: August 2022

In recent years, the role of biocompatible nanocarriers (BNs) and their cancer cell targeting efficiency in photodynamic therapy (PDT) holds potential benefits for cancer treatment. Biocompatible and biodegradable nanoparticles are successfully used as carrier molecules to deliver cancer drugs and photosensitizers due to their material safety in the drug delivery system. Biocompatible nanocarriers are non-toxic and ensure high-level biocompatibility with blood, cells, and physiological conditions. The physicochemical properties of BNs often enable them to modify their surface chemistry, which makes conjugating specific ligands or antibodies to achieve cancer cell targeting drug delivery in PDT. This review article focuses on the various types of BNs used in targeted drug delivery, physicochemical properties, and surface chemistry of BNs in targeted drug delivery, advantages of BNs in drug delivery systems, and the targeting efficiency of BNs on some specific targeting receptors for cancer therapy. Furthermore, the review briefly recaps the nanocarrier-based targeted approaches in cancer PDT.
Insight on the regulation mechanism of the nanochannels in hard and brittle materials induced by sparially shaped femtosecond laser
Authors: Kai Lin , Chen Caiyi , Lu Yu , Meng Yizhao , Liu Yi , Cheng Yang , Yang Qing , Hou Xun , Chen Feng
Published: August 2022

The efficient fabrication of nanochannels on hard and brittle materials is a difficult task in the field of micro and nano processing. We have realized nanochannel arrays on silica with characteristic scales varying from 50–230 nm using a single femtosecond Bessel beam pulse of 515 nm. By characterizing the surface openings, we found that the characteristic scales of the nanopore openings are inextricably linked to the surface energy deposition effect. We achieved not only three asymmetric channel profiles by adjusting the laser-sample interaction region, but also high aspect ratio nanochannels with characteristic scales about 50 nm and aspect ratios over 100. These results on hard and brittle materials provide a broader platform and application scenarios for smart particle rectifiers, DNA molecular sequencing, biosensors, and nanofluidic devices, which are also more suitable for future practical applications due to their low cost, good durability, and high productivity.
Echinococcus granulosus: The establishment of the metacestode in the liver is associated with control of the CD4+ T-cell-mediated immune response in patients with cystic echinococcosis and a mouse model
Authors: Hou Xinling , Shi Yang , Kang Xuejiao , Rousu Zibigu· , Li Dewei , Wang Maolin , Ainiwaer Abidan· , Zheng Xuran , Wang MingKun , Jiensihan Bahejiang· , Li Liang , Li Jing , Wang Hui , Zhang Chuanshan
Published: August 2022

The larval stage of the tapeworm Echinococcus granulosus sensu lato (E. granulosus s.l.) caused a chronic infection, known as cystic echinococcosis (CE), which is a worldwide public health problem. The human secondary CE is caused by the dissemination of protoscoleces (PSCs) when fertile cysts are accidentally ruptured, followed by development of PSCs into new metacestodes. The local immune mechanisms responsible for the establishment and established phases after infection with E. granulosus s.l. are not clear. Here, we showed that T cells were involved in the formation of the immune environment in the liver in CE patients and Echinococcus granulosus sensu strict (E. granulosus s.s.)-infected mice, with CD4+ T cells being the dominant immune cells; this process was closely associated with cyst viability and establishment. Local T2-type responses in the liver were permissive for early infection establishment by E. granulosus s.s. between 4 and 6 weeks in the experimental model. CD4+ T-cell deficiency promoted PSC development into cysts in the liver in E. granulosus s.s.-infected mice. In addition, CD4+ T-cell-mediated cellular immune responses and IL-10-producing CD8+ T cells play a critical role in the establishment phase of secondary E. granulosus s.s. PSC infection. These data contribute to the understanding of local immune responses to CE and the design of new therapies by restoring effective immune responses and blocking evasion mechanisms during the establishment phase of infection.
Minor perturbations of thyroid homeostasis and major cardiovascular endpoints—Physiological mechanisms and clinical evidence
Authors: Müller Patrick , Leow Melvin Khee-Shing , Dietrich Johannes W.
Published: August 2022

It is well established that thyroid dysfunction is linked to an increased risk of cardiovascular morbidity and mortality. The pleiotropic action of thyroid hormones strongly impacts the cardiovascular system and affects both the generation of the normal heart rhythm and arrhythmia. A meta-analysis of published evidence suggests a positive association of FT4 concentration with major adverse cardiovascular end points (MACE), but this association only partially extends to TSH. The risk for cardiovascular death is increased in both subclinical hypothyroidism and subclinical thyrotoxicosis. Several published studies found associations of TSH and FT4 concentrations, respectively, with major cardiovascular endpoints. Both reduced and elevated TSH concentrations predict the cardiovascular risk, and this association extends to TSH gradients within the reference range. Likewise, increased FT4 concentrations, but high-normal FT4 within its reference range as well, herald a poor outcome. These observations translate to a monotonic and sensitive effect of FT4 and a U-shaped relationship between TSH and cardiovascular risk. Up to now, the pathophysiological mechanism of this complex pattern of association is poorly understood. Integrating the available evidence suggests a dual etiology of elevated FT4 concentration, comprising both ensuing primary hypothyroidism and a raised set point of thyroid function, e. g. in the context of psychiatric disease, chronic stress and type 2 allostatic load. Addressing the association between thyroid homeostasis and cardiovascular diseases from a systems perspective could pave the way to new directions of research and a more personalized approach to the treatment of patients with cardiovascular risk.