bluuebunny/crossref_metadata_2025 huggingface dataset:
ALÎ ŞÎR NEVÂYÎ’NİN NEVÂDİRÜ’Ş-ŞEBÂB’INDA ORGAN İSİMLERİYLE KURULAN DEYİMLER ÜZERİNE BİR İNCELEME
Authors: Akman Hami
Published: April 2024

Çağatay Türkçesi ve Türk edebiyatı için oldukça önemli bir yere sahip olan Ali Şîr Nevâyi, 1441’de Herat’ta dünyaya gelmiş ve doğduğu yerde de 1501 yılında vefat etmiştir. Nevâyî’nin, Farsçanın resmi dil olarak hüküm sürdüğü bir ortamda klâsik Çağatay edebiyatının oluşumunda oldukça etkin bir rol oynadığı bilinmektedir. Bugüne kadar eserleri üzerinde sayısız çalışma yapılmıştır. Bu çalışmada da Nevâyî’nin ikinci divanı olan Nevâdirü’ş-Şebâb (Gençlik Çağlarının Nadireleri) adlı eserinde yer alan organ adlarıyla kurulmuş deyimler ele alınıp incelenmiştir. Yapılan inceleme neticesinde söz konusu eserde organ adlarıyla kurulan deyim sayısı 234 olarak belirlenmiştir. Özellikle baş kelimesiyle kurulan 47, gönül kelimesiyle kurulan 55, göz kelimesiyle kurulan 44, yüz kelimesiyle kurulan 19 deyim sayısal fazlalıklarıyla ve karşıladıkları kavramların çeşitliliğiyle dikkat çekicidirler. Çalışmanın giriş kısmında kısaca Alî Şîr Nevâyî’nin hayatına ve edebî kişiliğine, deyime ve organ adlarının deyim oluşumundaki önemine değinilmiştir. Çalışmanın ana kısmında Nevâdirü’ş-Şebâb’da yer alan organ isimleriyle kurulmuş deyimler alfabetik sıra gözetilerek verilmiştir. Sonuç kısmında söz konusu eserdeki deyimler karşıladıkları kavramlar ve sayısal verileri dikkate alınarak, tablodan da faydalanılarak genel bir değerlendirilmeye tabi tutulmuştur.
ÖĞRETMEN ADAYLARININ KAPSAYICI EĞİTİME İLİŞKİN GÖRÜŞLERİ
Authors: Aslan Osman , Demirbaş İbrahim
Published: April 2024

Kapsayıcı eğitim, öğrencilere fırsat ve imkân eşitliği sunar ve her bireyin nitelikli eğitim olanaklarından faydalanmasını destekler. Sosyal ve toplumsal dokularda oluşabilen uyum sorunlarının ortadan kalmasına imkân verir. Böylece bireyler okula entegre olurken, yaşadığı sosyokültürel çevreye de uyum sağlar. Bu yüzden kapsayıcı eğitimin okullarda uygulanmasında öğretmenlerin farkındalık düzeylerinin yüksek olması oldukça önemlidir. Bu önem doğrultusunda araştırmanın en temel amacı, öğretmen adaylarının kapsayıcı eğitimine ilişkin görüşlerini ortaya çıkarmaktır. Çalışmada nitel araştırma yöntemleri kullanılmıştır. Araştırma yönteminin alt deseni ise durum çalışması olarak yapılandırılmıştır. Araştırmaya Ağrı İbrahim Çeçen Üniversitesi sınıf eğitimi ana bilim dalı öğrencilerinden 33’ü kadın, 19’u erkek olmak üzere toplam 52 öğretmen adayı katılmıştır. Araştırmada veriler, standartlaştırılmış açık uçlu görüşme formu kullanılarak elde edilmiştir. Görüşme formu soruları, Millî Eğitim Bakanlığı ve UNİCEF iş birliğinde oluşturulan, Kapsayıcı Eğitme Giriş – Kendi Kendine Öğrenme Modülünden alınmıştır. Veriler Google Form aracılığı ile internet ortamında öğrencilere ulaştırılmış ve yanıtları alınmıştır. Öğretmen adaylarından elde edilen veriler, nitel veri analiz yöntemlerinden olan betimsel analiz yöntemi ile analiz edilmiştir. Betimsel analiz yöntemi ile veriler kategorik hâle dönüştürülmüş, yüzde ve frekans olarak ifade edilmiştir. Böylece veriler yorumlanabilir hâle gelmiştir. Araştırma sonucunda; kapsayıcı eğitim açısından sınıf ortamının heterojen bir yapıda olması gerektiği, homojen sınıflarda öğrenci çeşitliliğinin az olması sebebi ile sınıf ikliminin istenilen düzeyde olmayacağı, kültürel farklılıkların sınıf iklimine taşınamayacağı, homojen okulların oluşturulmasının ekonomik açıdan oldukça maliyetli olacağı tespit edilmiştir. Ayrıca; ilköğretim okulları ve liselerde dışlanan ve ayrımcılığa mazur kalan öğrencilerin ve grupların olduğu, bunların büyük bir bölümünün kapsayıcı eğitim ile okula entegre edilmediği de görülmüştür.
Ortaokul Öğrencilerinin Eleştirel Düşünme Eğilimleri ile Okuma Becerileri Arasındaki İlişkiye Yönelik Görüşleri
Authors: Yıldırım Döner Seyhan , Demir Sezgin
Published: April 2024

Eleştirel düşünme, felsefenin ilk dönemlerine dayanan ve bilim insanlarınca hâlâ tanımlanan, boyutlandırılan ve hemen her alanda etkisi gözlemlenen bir kavramdır. Eleştirel düşünme, bir konunun derinlemesine düşünülerek analizini yapmanın sonucunda bir yargıya varmaktır. Bu sürecin içerisinde yer alan her bir adım, bireyin okuma eyleminin zihinsel boyutlarıyla ilişkilidir. Okunanı zihinsel olarak anlamlandırma sürecinde eleştirel düşünmenin basamak ve boyutları olan akıl yürütme, derinlemesine düşünme, analiz yapma, değerlendirme, sonuç çıkarma, neden-sonuç ilişkisi kurma da kullanılmaktadır. Bu doğrultuda bu çalışmada, ortaokul öğrencilerinin eleştirel düşünme eğilimleri ile okuma becerileri arasındaki ilişkiye yönelik öğrencilerin görüşlerinin belirlenmesi amaçlanmıştır. Çalışma nitel araştırma türlerinden olgubilimsel desende gerçekleştirilmiştir. Çalışma grubunu oluşturan 16 katılımcı ile gönüllülük esasına göre bire bir yarı yapılandırılmış görüşmeler gerçekleştirilmiş, elde edilen veriler içerik ve betimsel analize tabi tutulmuştur. Çalışmanın sonucunda ortaokul öğrencilerinin eleştirel düşünme eğilimleriyle okuma becerileri arasında olumlu bir ilişki olduğunu düşündükleri, okuma sürecinde eleştirel düşünmeyi aktif ve bilinçli bir şekilde kullandıkları, eleştirel düşünmeye karşı olumlu bir tutum içerisinde oldukları, okuma sürecinde eleştirel düşünmeye eğilimli oldukları, eleştirel düşünme sayesinde okuduklarını daha iyi anladıkları sonucuna ulaşılmıştır. Anahtar Kelimeler : eleştirel düşünme eğilimi, okuma becerileri, nitel araştırma.
Strategi Orang Tua dalam Upaya Mencegah Kekerasan Seksual pada Anak Usia Dini
Authors: Wulandari Hayani Wulandari , Nurjanah Ayu Sufi
Published: April 2024

Kekerasan seksual adalah salah satu masalah kesehatan di dunia yang sering kali terjadi, termasuk di Indonesia. Tujuan penelitian adalah untuk mengetahui strategi yang dilakukan oleh orang tua dalam upaya mencegah kekerasan seksual pada anak usia dini. Desain penelitian yang digunakan adalah kajian literatur. Pengumpulan data dilakukan melalui berbagai sumber, yaitu buku, skripsi, thesis, disertasi, dan publikasi artikel jurnal. Berdasarkan hasil kajian literatur menunjukkan bahwa strategi yang dilakukan oleh orang tua dalam upaya mencegah kekerasan seksual pada anak usia dini, antara lain yaitu memiliki pengetahuan tentang pendidikan seksual, berpikiran terbuka, persepsi yang positif, dan memiliki tanggung jawab.
MARY DOUGLAS
Authors: 6 Perri , Richards Paul
Published: April 2024

Mary Douglas’s innovative explanations for styles of human thought and for the dynamics of institutional change have furnished a distinctive and powerful theory of how conflicts are managed, yet her work remains astonishingly poorly appreciated in social science disciplines. This volume introduces Douglas’s theories, and outlines the ways in which her work is of continuing importance for the future of the social sciences. Mary Douglas: Understanding Human Thought and Conflict shows how Douglas laid out the agenda for revitalizing social science by reworking Durkheim’s legacy for today, and reviews the growing body of research across the social sciences which has used, tested or developed her approach.
Primer registro de Lyncodon patagonicus (de Blainville, 1842) (Mammalia, Mustelidae) para el Parque Nacional Talampaya, La Rioja, República Argentina
Authors: Castillo Luciana L. , Martínez Retta Lucía , Gatica Ailin , Pardo Víctor M.
Published: April 2024

En este trabajo se reporta el primer registro para Lyncodon patagonicus en el Parque Nacional Talampaya, provincia de La Rioja, Argentina. El mismo consiste en un registro fílmico proveniente de trampas cámara, donde también se observa la interacción de la especie con Lycalopex gymnocercus. Este dato aumenta las localidades de registro de L. patagonicus, considerada una especie rara y vulnerable, ampliando su presencia a cuatro áreas protegidas.
Pengaruh Lifestyle, Selebgram dan Costumer Review Terhadap Keputusan Pembelian di Media Sosial Instagram (Studi Eksplanatif pada Followers Selebgram Palembang @Jihannabilaaaaa)
Authors: Putri Pratiwi Mayang Sari , Erdiansyah Erdiansyah , Robyardi Erfan
Published: April 2024

ABSTRACT
The aim of this research is to find out how lifestyle, celebrity and customer reviews influence purchasing decisions on Instagram social media. This research is a survey research with three independent variables lifestyle, celebgram and customer reviews as well as the dependent variable purchasing decisions, using data collection techniques by distributing questionnaires to 100 respondents who are followers of the Palembang celebgram @jihannabilaaaaa. The sampling technique is accidental sampling. For data analysis using multiple regression analysis. The research results show that the customer review variable has a greater influence than the lifestyle and celebrity variables. The results show that consumers have an orientation towards customer reviews regarding purchasing decisions on Instagram social media compared to lifestyle and celebrity programs. So that business people can increase sales promotions through customer reviews from all consumers as a strategy development in marketing so that consumers are interested and can generate interest in purchasing.
Keywords: Lifestyle, Celebrity, Customer Reviews, and Purchase Decisions.
 
ABSTRAK
Tujuan dari penelitian ini untuk mengetahui bagaimana pengaruh lifestyle, selebgram dan costumer review terhadap keputusan pembelian di media sosial instagram. Penelitian ini merupakan penelitian survey dengan tiga variabel bebas lifestyle, selebgram dan costumer review serta variabel terikat keputusan pembelian, dengan menggunakan teknik pengumpulan data dengan menyebarkan kuesioner terhadap 100 responden followers selebgram palembang @jihannabilaaaaa. Teknik sampling yaitu accidental sampling. Untuk analisis data menggunakan analisis regresi berganda. Hasil penelitian menunjukan bahwa variabel costumer review lebih besar pengaruhnya daripada variabel lifestyle dan selebgram. Hasil menunjukan konsumen memiliki orientasi pada costumer review terhadap keputusan pembelian di media sosial instagram dibandingkan dengan lifestyle dan selebgram. Sehingga para pelaku bisnis bisa meningkatkan promosi penjualanan melalui costumer review dari semua konsumen sebagai pengemabangan strategi dalam pemasaran sehingga konsumen tertarik dan dapat menimbulkan minat pembelian.
Kata kunci: Lifestyle,Selebgram, Costumer Review, dan Keputusan Pembelian.
Einfluss der Erntestrategie auf die genetische Vielfalt des Saatguts bei Eichen
Authors: Haldemann Cristina , Rudow Andreas , Bonfils Patrick , De Boni Andrea , Reiss Gabor , Streit Kathrin , Studhalter Stefan , Rellstab Christian
Published: April 2024

Genetische Vielfalt ist Grundvoraussetzung dafür, dass sich Arten an sich ändernde Umweltbedingungen wie den Klimawandel anpassen und gegenüber extremen Umweltereignissen resilient sind. Bei der künstlichen Verjüngung zukunftsfähiger Baumbestände sollte deshalb genetisch vielfältiges Vermehrungsgut (Saat- und Pflanzgut) verwendet werden. Die Beerntung von Saatgut erfolgt heute jedoch aus Effizienz- und Kostengründen häufig opportunistisch und nicht mit dem Ziel, eine hohe genetische Vielfalt zu erreichen. Die Anpassungsfähigkeit des gesammelten Saatguts könnte dadurch eingeschränkt sein. Mit molekulargenetischen Analysen von 216 (potenziellen) Mutterbäumen und 1037 Eicheln untersuchten wir in je einem Samenerntebestand für Stielund Traubeneiche, wie sich die Samenerntestrategie auf die neutrale, nicht fitness-relevante genetische Vielfalt des Saatguts auswirkt. Unsere Resultate zeigen, dass die genetische Vielfalt des Saatguts vor allem von der Anzahl Mutterbäume und Eicheln pro Mutterbaum abhängt. Bereits 100 Eicheln reichten, um fast die gesamte genetische Vielfalt aller Eicheln eines Mutterbaumes zu sammeln, was mit der gängigen Samenerntepraxis gegeben ist. Um 75–95% der totalen genetischen Vielfalt eines Samenerntebestandes zu erreichen, waren 19–43 Mutterbäume notwendig – also deutlich mehr als in der Praxis üblich. Die Samenernte in verschiedenen Sektoren (Waldabschnitten) und die Vermeidung von nahe gelegenen Halbgeschwistern hatten hingegen einen geringen Einfluss. Zusammenfassend sollte sich die Samenernte also auf eine möglichst hohe Anzahl Mutterbäume fokussieren, was bei den Eichen mit kleinem finanziellem Aufwand möglich ist. Wegen der Anpassung an kleinräumige Standorteigenschaften würde sich die Samenernte in mehreren Sektoren aber wohl lohnen, wenn sich diese hinsichtlich ihrer ökologischen Eigenschaften unterscheiden. Diese Erkenntnisse unterstreichen die Notwendigkeit von praktischen Hinweisen und Richtlinien zur Optimierung der Samenernte. Zudem sind sie eine nützliche Grundlage für die strategische Planung von Baumschulen und tragen zur Anpassungsfähigkeit unserer Baumarten und zur Resilienz des zukünftigen Waldes bei.
Role of Micro Ribonucleic Acid-124 in Protecting Against Nerve Injury After Cerebral Ischemia/Reperfusion
Authors: Wen Li
Published: April 2024

The researchers aimed to evaluate micro ribonucleic acid (miR)-124 for its protective role in nerve injury in rats following cerebral ischemia/reperfusion. A focal middle cerebral artery embolism model was constructed. Compared with sham operation group, model and miR-124 NC groups had significantly increased miR-124 expression, neurobehavioral score, malondialdehyde (MDA) content, brain infarct volume, and apoptosis rate, elevated expression levels of Bcl-2- associated X (Bax) protein as well as cleaved caspase-3, 8 and 9, attenuated activity of superoxide dismutase (SOD), and lowered expression of B-cell lymphoma 2 (Bcl-2) (P<0.01). By contrast to those in model and miR-124 NC groups, Bcl- 2 expression rose, miR-124 expression, neurobehavioral score, brain infarct volume percentage and apoptosis rate reduced, Bax, cleaved caspase-3, 8 and 9 expression levels declined, SOD activity enhanced, and MDA content in miR- 124 mimic group dropped (P<0.01). In conclusion, miR-124 protects rats from nerve injury after cerebral ischemia/ reperfusion by improving the antioxidant capacity and regulating the expressions of apoptosis-associated proteins.
Зміни асоційованої зі здоров’ям якості життя в пацієнтів зі стабільною ішемічною хворобою серця та проміжними ураженнями вінцевих артерій після планового перкутанного коронарного втручання
Authors: Стан М. В. , Міхалєв К. О. , Жарінов О. Й. , Хохлов А. В.
Published: April 2024

The aim – to analyze the factors, associated with the change in health-related quality of life (HRQoL) in stable coronary artery disease (SCAD) patients with intermediate coronary lesions at 3-months follow-up after elective percutaneous coronary intervention (PCI).Materials and methods. A prospective single-center study enrolled 84 SCAD patients (mean age 64±8 years; males – 73 %) with intermediate coronary lesions (stenosis 50-90 %) (by invasive coronary angiography [ICA]), consecutively enrolled and hospitalized with the aim of elective PCI to be performed. HRQoL was evaluated by SF-36 (physical health summary [PHsum] and mental health summary [МНsum]) and SAQ (Seattle Angina Questionnaire»; the domains «physical limitation» [PL], «angina stability» [AS], «angina frequency» [AF], «treatment satisfaction» [TS] and «disease perception» [DP]), – at baseline and 3-months follow-up. The enrolled sample was subdivided in a dichotomous manner into the HRQoL «improvement» or «non-improvement» patterns, based on the cut-off-values (COVs) of clinically meaningful change of the certain HRQoL parameter score at 3-months follow-up after PCI.Results and discussion. We revealed an improvement of average (median) HRQoL parameters at 3-months follow-up after PCI, namely PHsum (score increase from 38.8 to 43.1; р < 0.001), SAQ-AS (25 to 75; р < 0.001), SAQ-AF (70 to 80; р  <  0.001), SAQ-TS (58.8 to 70.6; р < 0.001) and SAQ-DP (45.8 to 66.7; р < 0.001). The clinically meaningful HRQoL improvement ranged from 14 % to 71 % cases, depending on the certain HRQoL parameter and the COVs of its change at follow-up after PCI. The worse baseline HRQoL, older age and higher baseline total cholesterol level were the factors, associated with the increased probability of HRQoL to be meaningfully improved after revascularization. In addition, a presence of diabetes mellitus, a history of acute cerebrovascular accident, and the ICA data on multivessel disease and in-stent restenosis after previous PCI, – all were associated with the lower odds of HRQoL «improvement» status to be achieved.Conclusions. A PCI favored the HRQoL improvement in SCAD patients at 3-months follow-up. The clinical and angiographic factors, associated with the post-procedure change in HRQoL, should be considered for a better selection of SCAD patients with intermediate coronary lesions for PCI.
Perlindungan Hukum Terhadap Konsumen dalam Penarikan Objek Jaminan Fidusia oleh Debt Collector Akibat Wanprestasi Pada Perusahaan Pembiayaan
Authors: Faniyah Iyah , Syurya Alhadi. A
Published: April 2024

Pasal 4 huruf e Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen mengatur bahwa setiap konsumen berhak untuk mendapatkan advokasi, perlindungan, dan upaya penyelesaian sengketa perlindungan konsumen secara patut. Namun, dalam praktiknya banyak terjadi penarikan objek jaminan fidusia dari konsumen secara paksa saat konsumen tidak membayar kredit tepat waktu. Penelitian ini membahas Perlindungan Hukum Terhadap Konsumen Dalam Penarikan Objek Jaminan Fidusia dan kendala-kendala yang dihadapi untuk memperoleh perlindungan hukum tersebut. Pendekatan yang digunakan adalah pendekatan yuridis normatif, dengan melakukan penelitian terhadap aturan-aturan hukum terkait penarikan jaminan fidusia oleh debt collector. Didukung pendekatan yuridis empiris, dengan melakukan penelitian untuk melihat bekerjanya aturan-aturan hukum tersebut dalam prakteknya pada penarikan jaimanan fiducia oleh debt collector pada Perusahaan pembiayaan. Hasil penelitian menunjukkan Pertama, perlindungan hukum terhadap konsumen dalam penarikan objek jaminan fidusia oleh debt collector akibat wanprestasi pada perusahaan pembiayaan mencakup: 1) Perlindungan hukum preventif adalah adanya POJK Nomor 6 /POJK.07/2022 dan Peraturan Bank Indonesia Nomor 23/6/PBI/2021  yang memuat ketentuan penagihan kredit oleh debt collector, yaitu: (1) menunjukkan identitas resmi; (2) memiliki sertifikat profesi; (3) adanya perjanjian tertulis penggunaan jasa debt collector; (4) Penagihan tidak boleh memakai ancaman, kekerasan atau mempermalukan debitur; (5) dilarang menggunakan kekerasan verbal; (7) dilarang meneror; b) Perlindungan hukum represif yaitu a) adanya sanksi pidana terhadap perusahaan pembiayaan yang sengaja memalsukan, mengubah, menghilangkan atau dengan cara apapun memberikan keterangan secara menyesatkan dalam perjanjian dengan konsumen; b) eksekusi atas objek jaminan fiduasia yang dilakukan dengan cara bertentangan dengan undang-undang dapat membatalkan perjanjian; c) Sanksi pidana terhadap perusahaan pembiayaan yang melakukan eksekusi objek jaminan fidusia secara paksa dari konsumen. Kedua, Kendala-kendala yang dihadapi konsumen dalam penarikan objek jaminan fidusia oleh debt collector akibat wanprestasi pada perusahaan pembiayaan  adalah: a) Ketentuan penarikan objek jaminan fidusia yang kontradiktif satu sama lain dan rumusannya tidak jelas serta tegas, b) Terlalu banyak peranan lembaga yang terlibat dalam penegakan hukum UUPK, c) Tidak ada Standar Operasional Perusahaan (SOP) terkait penarikan objek jaminan fidusia dalam perjanjian yang telah disepakati oleh konsumen dan perusahaan pembiayaan, d) Perusahaan pembiayaan tidak patuh terhadap aturan yang ada, e) perusahaan pembiayaan tidak melaksanakan putusan badan penyelesaian sengketa konsumen dengan sukarela, dan f) pengetahuan konsumen yang rendah terkait perlindungan hukum terhadap dirinya.
The Associations Between Serum Insulin-like Growth Factor-I, Brain White Matter Volumes, and Cognition in Mild Cognitive Impairment and Alzheimer’s Disease
Authors: Horvath Alexandra , Quinlan Patrick , Eckerström Carl , Åberg N. David , Wallin Anders , Svensson Johan
Published: April 2024

Background: Insulin-like growth factor-I (IGF-I) regulates myelin, but little is known whether IGF-I associates with white matter functions in subjective and objective mild cognitive impairment (SCI/MCI) or Alzheimer’s disease (AD). Objective: To explore whether serum IGF-I is associated with magnetic resonance imaging – estimated brain white matter volumes or cognitive functions. Methods: In a prospective study of SCI/MCI (n = 106) and AD (n = 59), we evaluated the volumes of the total white matter, corpus callosum (CC), and white matter hyperintensities (WMHs) as well as Mini-Mental State Examination (MMSE), Trail Making Test A and B (TMT-A/B), and Stroop tests I–III at baseline, and after 2 years. Results: IGF-I was comparable in SCI/MCI and AD (113 versus 118 ng/mL, p = 0.44). In SCI/MCI patients, the correlations between higher baseline IGF-I and greater baseline and 2-year volumes of the total white matter and total CC lost statistical significance after adjustment for intracranial volume and other covariates. However, after adjustment for covariates, higher baseline IGF-I correlated with better baseline scores of MMSE and Stroop test II in SCI/MCI and with better baseline results of TMT-B and Stroop test I in AD. IGF-I did not correlate with WMH volumes or changes in any of the variables. Conclusions: Both in SCI/MCI and AD, higher IGF-I was associated with better attention/executive functions at baseline after adjustment for covariates. Furthermore, the baseline associations between IGF-I and neuropsychological test results in AD may argue against significant IGF-I resistance in the AD brain.
Evaluation of the Quality and Readability of Online Information about Alzheimer’s Disease in China
Authors: Chu Yili , Xie Qihui , Meng Rongrong , Leng Bing , Cao Zhenxiang
Published: April 2024

Background: With the increasing popularity of the internet, a growing number of patients and their companions are actively seeking health-related information online. Objective: The aim of this study was to assess the quality and readability of online information about Alzheimer’s disease (AD) in China. Methods: A total of 263 qualified AD-related web pages from different businesses, governments, and hospitals were obtained. The quality of the web pages was assessed using the DISCERN tool, and the readability of the web pages was assessed using a readability measurement website suitable for the Chinese language. The differences in readability and quality between different types of web pages were investigated, and the correlation between quality and readability was analyzed. Results: The mean overall DISCERN score was 40.93±7.5. The government group scored significantly higher than the commercial and hospital groups. The mean readability score was 12.74±1.27, and the commercial group had the lowest readability score. There was a positive correlation between DISCERN scores and readability scores. Conclusions: This study presents an evaluation of the quality and readability of health information pertaining to AD in China. The findings indicate that there is a need to enhance the quality and readability of web pages about AD in China. Recommendations for improvement are proposed in light of these findings.
Language and Meaning: Asymptomatic Alzheimer’s Disease in the Clinic and Society
Authors: Gale Seth A.
Published: April 2024

As the biological, biomarker-driven framework of Alzheimer’s disease (AD) becomes formalized through revised, consensus clinical criteria, clinicians will confront more and more patients in the earliest, asymptomatic stages of disease. The language and diction used by practitioners to characterize these early patients, whether they are diagnosed with AD, and how their condition is documented in medical and legal records have important implications for both their care and their medical-legal status outside of the health system. Investigation is needed urgently to better understand clinicians’ views and practices regarding early AD, as we adapt to new disease definitions in this unprecedented era of care.
GAMNet: A deep learning approach for precise gesture identification
Authors: Amrutha Raj V. , Malu G.
Published: April 2024

Deep learning has gained popularity across several industries, including object recognition and classification. In the case of Convolutional Neural Networks (CNN), the first layers extract the most noticeable elements, such as shape and margin. As the model progresses, it learns to extract more complex features such as texture and color; conversely, skeleton features encompass significant locations (joints) that do not naturally align with the grid-like architecture intended for these networks. This study emphasizes the importance of structural features in enhancing the performance of deep learning models. It introduces the Gesture Analysis Module Network (GAMNet), which computes abstract structural values within the architecture for feature extraction, prioritization, and classification. These values go through a rigorous evaluation process along with the cutting-edge deep learning model, CNN, and result in intermediate representations, leading to better performance in gesture analysis. An automated dance gesture identification system can address the challenges of recognizing hand movements in unpredictable lighting, varied backgrounds, noise, and changing camera angles. Despite these challenges, GAMNet performed remarkably well, surpassing renowned models like VGGNet, ResNet, EfficientNet, and CNN, achieving a classification accuracy of 96.80%, even in challenging image circumstances. This paper highlights how GAMNet can revolutionize the world of classical Indian dance, opening up new opportunities for research and development in this field.
RETRACTED: Computer graphics assisted methods in cultural and creative product design and graphic design: A study of visual interaction and innovative practices
Authors: Wei YuHan , Kim Young-Ju
Published: April 2024

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Duchenne Muscular Dystrophy-Associated Neurobehavioral Difficulties: Insights from Clinical Practice
Authors: Geuens Sam , Goemans Nathalie , Lemiere Jurgen , Doorenweerd Nathalie , De Waele Liesbeth
Published: April 2024

Background:

Emerging evidence underscores the high prevalence of neurobehavioral difficulties like ADHD, ASD and OCD, in patients with Duchenne muscular dystrophy (DMD). The substantial impact of these complex behavioral challenges in addition to motor function decline on the well-being of affected individuals and their families is increasingly evident. However, a uniform approach for effective screening, assessment and management of the neurobehavioral symptoms remains elusive.

Objective:

We explored strategies used by healthcare professionals with clinical expertise in DMD to address neurobehavioral symptoms, in order to uncover diverse practices and to identify potential directions for clinical approaches in managing DMD neurobehavioral symptoms.

Methods and results:

Twenty-eight respondents from 16 different countries completed an online survey. Only 35% of the centers systematically screened for neurobehavioral difficulties in their DMD population. Predominant screening methods included history taking and clinical observation. Common neurobehavioral difficulties encompassed learning challenges, dependency from adults, anxiety, concentration difficulties, and social deficits. The participating centers frequently employed parental counseling and liaison with psychosocial healthcare professionals for psychosocial intervention.

Conclusion:

This study underscores the complex behavioral landscape in DMD, highlighting the need for validated screening, assessment and management strategies and collaborative efforts in implementing these. We advocate for international consensus recommendations for screening, assessment and management of neurobehavioral difficulties in DMD to enhance patient care and communication across healthcare settings.
Patient and Public Involvement and Engagement in the Development of a Platform Clinical Trial for Parkinson’s Disease: An Evaluation Protocol
Authors: Zeissler Marie-Louise , Bakshi Nikul , Bartlett Michèle , Batla Amit , Byrom David , Chapman Rebecca , Collins Sally , Cowd Elaine , Deeson Eric , Ellis-Doyle Romy , Forbes Jodie , Gonzalez-Robles Cristina , Jewell Anna , Lane Emma L. , LaPelle Nancy R. , Martin Keith , Matthews Helen , Miller Laurel , Mills Georgia , Morgan Antony , Parry Miriam , Pushparatnam Kuhan , Ratcliffe Natasha , Salathiel Dorothy , Scurfield Paula , Siu Carroll , Whipps Sue , Wonnacott Sheila , Foltynie Thomas , Carroll Camille B. , McFarthing Kevin ,   on behalf of the EJS ACT-PD consortium
Published: April 2024

Background:

Patient and public involvement and engagement (PPIE) in the design of trials is important, as participant experience critically impacts delivery. The Edmond J Safra Accelerating Clinical Trials in PD (EJS ACT-PD) initiative is a UK consortium designing a platform trial for disease modifying therapies in PD.

Objective:

The integration of PPIE in all aspects of trial design and its evaluation throughout the project.

Methods:

PwP and care partners were recruited to a PPIE working group (WG) via UK Parkinson’s charities, investigator patient groups and participants of a Delphi study on trial design. They are supported by charity representatives, trial delivery experts, researchers and core project team members. PPIE is fully embedded within the consortium’s five other WGs and steering group. The group’s terms of reference, processes for effective working and PPIE evaluation were co-developed with PPIE contributors.

Results:

11 PwP and 4 care partners have supported the PPIE WG and contributed to the development of processes for effective working. A mixed methods research-in-action study is ongoing to evaluate PPIE within the consortium. This includes the Patient Engagement in Research Scale -a quantitative PPIE quality measure; semi-structured interviews -identifying areas for improvement and overall impressions of involvement; process fidelity- recording adherence; project documentation review – identifying impact of PPIE on project outputs.

Conclusions:

We provide a practical example of PPIE in complex projects. Evaluating feasibility, experiences and impact of PPIE involvement in EJS ACT-PD will inform similar programs on effective strategies. This will help enable future patient-centered research.
Covid-19 infection in pregnant women: Auditory evaluation in infants
Authors: Cianfrone F. , Cantore I. , Cazzaniga C. , Tauro F. , Chiarelli R. , Bianco F. , Di Carmine F. , Cantiani A. , Colella M.G. , Ruscito P.
Published: April 2024

Recent studies showed that COVID-19 infection can affect cochleo-vestibular system. The possibility of a vertical transmission is controversial. Some studies suggested that it is possible but unlikely, others find no evidence of vertical transmission. The objective of this study was to investigate whether exposure to COVID-19 during pregnancy or at birth has an impact on the hearing of the offspring.

As part of the national hearing screening program, we performed in all newborns between January 2022 and February 2023, TEOAEs (Transient Evoked Otoacoustic Emissions) at birth and at 3 months. For those “REFER” at the third month test, we performed aABR (Automatic Auditory Brainstem Response) at 6 months. We analysed separately result between infants born to COVID-positive mothers during pregnancy and those born to COVID-negative mothers. To statistical verify differences we performed “Chi-square test”.

We enrolled a total of 157 infants, of whom 16 were born to mothers who had a molecular PCR test positive for COVID-19. In the latter we tested a total of 32 ears and only 1 ear (3,1%) resulted “REFER”. On the other hand, in the control group we tested a total of 282 ears and 22 (7,8%) were found to be “REFER”.

Our study showed no significant differences in audiological assessment between newborns exposed to COVID-19 infection during pregnancy or at birth compared to the unexposed group. However, further studies with a larger patient’s sample will be necessary for a more comprehensive evaluation.
AVALIAÇÃO FÍSICO-QUÍMICA E MICROBIOLÓGICA DO CAMARÃO Litopenaeus vannamei SUBMETIDO À DEFUMAÇÃO LÍQUIDA EM DIFERENTES TEMPERATURAS E TEMPOS DE PROCESSAMENTO
Authors: Campagnoli de Oliveira Filho Paulo Roberto , Da Silva Chirley Matilde , Estolano Macedo Indira Maria
Published: April 2024

Uma forma de conservar o camarão é com a utilização da defumação líquida. Este estudo objetivou avaliar aspectos físico-químicos e microbiológicos do camarão submetido à defumação líquida, testando diferentes tempos e temperaturas de processo. Os camarões foram defumados em estufa, utilizando fumaça líquida com os seguintes tratamentos: A -80° C/5h, B - 85° C/4h e C - 90° C/3h. Foram realizadas análises de rendimento, porcentagem de encolhimento, cor, textura, capacidade de retenção de água, atividade de água, umidade e análises microbiológicas. A defumação líquida dos camarões do tratamento A causou menor rendimento, maior porcentagem de encolhimento, maior capacidade de retenção de água, maior dureza e menor porcentagem de umidade e atividade de água. Nos camarões do tratamento C, houve maior rendimento, menor porcentagem de encolhimento, menor capacidade de retenção de água, menor dureza e maior porcentagem de umidade e atividade de água. Nas análises microbiológicas, os resultados se mantiveram de acordo com a legislação brasileira. Conclui-se que a defumação líquida dos camarões do tratamento C mostra-se mais adequada, tendo um grande potencial de produção e comercialização.
Palavras-chaves: pescado defumado, conservação, fumaça líquida, crustáceo.
Sífilis secundária: fator de descompensação de doença hepática subjacente? A propósito de um caso clínico
Authors:   USF Norton de Matos, León Alexandra Rodrigues , Mascarenhas Ana Luísa Melo ,   USF Norton de Matos, Ribeiro e Reis Ana Maria ,   USF Norton de Matos, Ferreira António Miguel Cruz ,   USF Norton de Matos, Montenegro Marta Álvares Ribeiro de Sousa Coutinho da Silveira ,   USF Norton de Matos
Published: April 2024

Introdução: A sífilis é uma infeção de notificação obrigatória, maioritariamente transmitida por via sexual, causada pela bactéria Treponema pallidum. As manifestações clínicas variam conforme o estadio da doença: sífilis precoce (doença primária e secundária) e sífilis tardia (latente ou terciária). A doença secundária é sistémica e desenvolve-se, após semanas ou meses, em aproximadamente 1/4 dos indivíduos com infeção primária não tratada. Neste estadio, a doença pode manifestar-se através de sintomas constitucionais, adenopatias, erupções cutâneas maculopapulares palmoplantares, manifestações hepáticas, renais ou neurológicas, entre outras. A serologia fornece um diagnóstico presuntivo, sendo necessários testes não treponémicos e treponémicos para estabelecer o diagnóstico de sífilis. A difícil interpretação dos achados serológicos associada a uma grande variedade de manifestações clínicas e a uma incidência crescente nos últimos anos torna o seu diagnóstico um desafio. Descrição do caso: Os autores descrevem o caso clínico de um adulto que apresenta um quadro de edema inaugural dos membros inferiores, cansaço e noção de distensão abdominal. Objetivamente apresenta lesões maculopapulares eritematosas, com descamação periférica, não pruriginosas, nas palmas das mãos e plantas dos pés. Após entrevista clínica completa coloca-se a hipótese de descompensação de doença hepática em contexto de sífilis secundária/hepatite sifilítica e envia-se o doente ao serviço de urgência, onde é confirmada a infeção. Comentário: Este caso demonstra que a grande variedade de manifestações clínicas torna o diagnóstico de sífilis um desafio. Uma vez feito o diagnóstico deve ser instituído tratamento com dose única de penicilina intramuscular, evitando potenciais consequências graves decorrentes da doença sistémica. Em suma, um médico de família deve ser capaz de reconhecer esta infeção, interpretando corretamente os testes serológicos e instituindo o tratamento recomendado.
Diabéticos sem semaglutido: que implicações?
Authors:   USF Linda-a-Velha, João Sara , Melícia André ,   USF Linda-a-Velha, Leite Raquel Baptista ,   USF Linda-a-Velha
Published: April 2024

Foi recentemente comunicado um problema no abastecimento do medicamento Ozempic® (semaglutido), situação que afetou vários países, incluindo Portugal. Este medicamento, um análogo do péptido-1 semelhante ao glucagon, está indicado no nosso país para o tratamento de diabetes mellitus tipo 2 insuficientemente controlada, sendo comparticipado apenas para estes doentes, desde que apresentem também um valor de índice de massa corporal igual ou superior a 35kg/m2. A ruptura de stock do fármaco parece ter sido devida à sua prescrição off-label, realizada com o objetivo da perda de peso em pessoas com excesso de peso ou obesos, mas não diabéticos. A utilização off-label do semaglutido em Portugal levanta vários problemas, nomeadamente éticos e económicos. Apesar dos esforços que têm sido feitos para a diminuição da prevalência de pessoas com excesso de peso e obesidade no nosso país, nomeadamente através da criação de programas de saúde, considera-se que ainda existe margem significativa para uma melhoria no âmbito da medicina preventiva.
Hereditary angioedema with normal C1-inhibitor levels: a rare case report
Authors:   Centro Hospitalar Universitário de Santo António, Santos Filipa Rodrigues dos , Falcão Inês ,   Centro Hospitalar Universitário de Santo António, Cunha Leonor ,   Centro Hospitalar Universitário de Santo António
Published: April 2024

Hereditary angioedema (HAE) is a rare, hereditary disease and its manifestations may be life-threatening. It differs from histaminergic angioedema since it shows different underlying mechanisms and, therefore, does not respond to antihistamine or adrenaline treatment. The authors present a case of hereditary angioedema to highlight the importance of prompt referral to the allergy and clinical immunology for further evaluation and correct diagnosis in case of suspicion of this entity.
Glossite migratória benigna: um relato de caso
Authors:   USF Faria Guimarães - ACeS Porto Oriental. Porto, Portugal., Pereira Pedro , Santos Maria Luísa ,   USF Faria Guimarães - ACeS Porto Oriental. Porto, Portugal.
Published: April 2024

Resumo Introdução: A glossite migratória benigna pode ser facilmente confundida com diagnósticos diferenciais que mimetiza com potencial prognóstico desfavorável se não identificados atempadamente – embora seja um achado comum na população geral, com uma prevalência estimada de até 3% em indivíduos saudáveis na população geral a nível mundial –, sendo importante o seu reconhecimento precoce. Descrição do caso: Homem de 22 anos, com antecedentes pessoais de perturbação de ansiedade generalizada e ataques de pânico, recorre a consulta de doença aguda nos cuidados de saúde primários por queixas de lesões na face superior e bordos laterais da língua com cerca de dois meses de evolução, com sensação de queimadura perante alimentos quentes e com evolução flutuante. O utente apresentava estudo analítico extenso sem alterações relevantes e ao exame físico eram objetiváveis as referidas alterações na mucosa jugal. Tendo sido já tratado com antifúngicos orais sem sucesso e dado o aspeto característico foi assumido o diagnóstico de exclusão de glossite migratória benigna e tranquilizado o utente. Comentário: A glossite migratória benigna (GMB) é uma entidade clínica relativamente comum na população geral saudável (prevalência de 1 a 3%), de base inflamatória crónica que afeta a língua e mucosa jugal adjacente, habitualmente com evolução flutuante e crónica. Apesar da sua benignidade e de geralmente ser assintomática, os sinais associados podem ser uma causa significativa de preocupação e ansiedade nos doentes, contribuindo para uma diminuição na qualidade de vida na ausência de tranquilização por parte do médico assistente.
Restrictions on human rights and extraordinary legal regimes
Authors: Popovych Tereziia , Baryska Yana , Maslyuk Oksana , Peresh Ivan , Pohoryelova Zoya
Published: April 2024

The war between Russia and Ukraine highlights the importance of the research. The resulting state of war has far-reaching consequences across all areas of Ukrainian society, including the basic liberties and entitlements of its people. Therefore, the aim of this scientific work is to explore how to lessen the detrimental consequences of restrictions considering different dimensions of individualsʼ opportunities in the conditions of an emergency situation. The methods used in this research include comparative legal analysis, legal hermeneutics, core scientific methods of analysis, synthesis, and others. The researchʼs central outcomes involve clarifying the legal essence of extraordinary regimes and identifying their characteristic features. It is revealed that in Ukraine, extraordinary regimes manifest in two forms – martial law and a state of emergency, with significant differences between them. The research also examines the cases of their implementation, notably that a state of emergency is predominantly declared during natural disasters, while martial law is imposed during armed aggression. The study also analyses national legislation regulating the imposition of extraordinary regimes, highlighting the main grounds for their introduction and the procedure. Attention is given to international acts, including conventions and pacts, defining circumstances under which a state can deviate from its obligations in emergencies. The international experience of regulating this institution is explored, particularly in Germany, Poland, and France. The research asserts that the most widespread basis for declaring a state of emergency globally has been the COVID-19 pandemic, while the full-scale armed invasion by the Russian Federation serves as a condition for imposing martial law in Ukraine. The findings of the research can be utilized for further investigations on related topics and for refining existing legislation concerning extraordinary regimes
Role of legal regulation in the establishment and development of the public administration system with local self-government aspects
Authors: Hysi Arben , Avdulaj Jonida , Shahini Ermir , Goga Irini , Shahini Elti
Published: April 2024

The evolution of society creates new trends that significantly affect the legal status of public administration, which necessitates an up-to-date study of the accompanying changes. The study therefore aims to analyse the current legal system of Albania and other countries in terms of the impact of legal acts on the entire system of public administration, including local self-government. A set of methods was used in the study, including the analysis, grouping, induction, formal legal and comparative legal approaches. The study identified the overall impact of legal regulation on the entire governance system and society, which was used to formulate specific aspects in which the real interaction of state mechanisms and legal influence takes place. The study analysed the current political and economic situation in Albania, which revealed the main trends in the country’s current strategic directions. Subsequently, the identified directions were studied in detail, which ultimately made it possible to substantiate the importance of the list of strategic legal acts in shaping the development of the entire public administration system. Examples from other countries, such as Germany, the United Kingdom and China, were also used to study this topic, identifying the main differences in the impact of legal regulation on the development of the system under consideration, considering the specific legal, social and economic situation of each country. In addition, the complex also examined the institution of local self-government, which showed how the level of decentralisation of such bodies can affect the success and efficiency of their functioning. In practical terms, this study can be useful for scholars who can deepen their understanding of the dynamics of public administration development and for officials who want to understand the essence of the interaction discussed in the study
Inequalities in the labour market: A legal perspective on causes and solutions
Authors: Beqiri Agim , Jeton Kelmendi , Shala Venet
Published: April 2024

The efficient functioning of the labour market is impossible without ensuring equal opportunities for all agents involved in the system of labour and economic relations. It is especially important to study the role of the state in this process as the main regulator of social relations. The purpose of this study was to analyse the possibilities of preventing inequality in the labour market with the help of legal instruments, in particular legislation. The main research methods used were analysis, modelling and forecasting. The study examined the dynamics and global trends of labour market inequality, emphasising the changes resulting from globalisation and liberalisation. It also assessed the impact of migration on employment, particularly in view of the movement of people from war-torn regions. To describe the current trends, supply and demand in the current labour market were studied. The legislation of North Macedonia was assessed in the context of combating inequality and discrimination in the labour market. It is concluded that, despite the existence of a certain set of laws and acts, there are still problems related primarily to gender discrimination. Certain recommendations are offered to improve the situation both in the legal framework and in some other areas: economic, social, and cultural. It was concluded that the use of a comprehensive policy, the key approaches to which were proposed in this study, would achieve significantly better results in terms of ensuring equality in the labour market in North Macedonia. The findings can be used to improve public policies and legislation to combat labour market inequality in North Macedonia. In addition, the information described can also be used by entrepreneurs to create long-term development strategies