bluuebunny/crossref_metadata_2025 huggingface dataset:
Semisynthetic Ferritin-based Nanoparticles with High Magnetic Anisotropy for Spatial Magnetic Manipulation and Inductive Heating
Authors: Neusch Andreas , Wiedwald Ulf , Novoselova Iuliia P. , Kuckla Daniel A. , Tetos Nikolaos , Sadik Sarah , Hagemann Philipp , Farle Michael , Monzel Cornelia
Published: April 2024

The human iron storage protein ferritin represents an appealing template to realise a semisynthetic magnetic nanoparticle (MNP) for spatial manipulation or inductive heating applications on a nanoscale. Ferritin consists of a protein cage of well-defined size (12 nm), which is genetically modifiable, biocompatible, and into which a magnetic core is synthesised. Here, we probe the magnetic response and hence the MNP’s suitability for (bio-)nanotechnological or nanomedical applications, when the core is doped with 7 % cobalt or 7 % zinc, in comparison to the undoped iron oxide MNP. The samples exhibit almost identical core and hydrodynamic sizes, along with their tunable magnetic core characteristics as verified by structural and magnetic characterisation. Cobalt doping significantly increased the MNP’s anisotropy and hence the heating power in comparison to the other magnetic cores with potential application as a mild heat mediator. Spatial magnetic manipulation was tested with MNPs inside droplets, the cell cytoplasm, or the cell nucleus, where the MNP surface conjugation with mEGFP and poly(ethylene glycol) gave rise to excellent intracellular stability and traceability within the complex biological environment. A magnetic stimulus (smaller than fN forces) results in the quick and reversible redistribution of the MNPs. The obtained data suggest that semisynthetic ferritin MNPs are highly versatile nanoagents and promising candidates for theranostic or (bio-)nanotechnological applications.
Short, Enantioselective Synthesis of Mevalonic Acid
Authors: Oconnell Ryan J. , Dolphin Nicholas J. , Wiest Olaf , Helquist Paul
Published: April 2024

A new enantioselective synthesis of mevalonic acid that is short, flexible, scalable to gram amounts, and uses readily available starting materials is reported. Enantioselective homoallylic epoxidation of isoprenol followed by enantiomeric enrichment gave the key epoxide intermediate. Further reactions led to either racemic mevalonic acid in 74% yield over two steps or the individual (R)- or (S)-enantiomer on a gram scale in 51% overall yield and ≥99% ee over five linear steps.
An efficient state-specific frozen natural orbital based equation of motion coupled cluster method for core-ionization energies: theory, implementation and benchmark
Authors: Manna Amrita , Jangid Bhavnesh , Pant Rakesh , Dutta Achintya Kumar
Published: April 2024

We have implemented a reduced-cost partial triples correction scheme to the equation of motion coupled cluster method for core-ionization energy based on state-specific natural orbitals. The second-order Algebraic Diagrammatic Construction (ADC) method is used to generate the state-specific natural orbital, which provides quicker convergence of the core IP value with respect to the size of the virtual space than that observed in standard MP2-based natural orbitals. The error due to the truncation of the virtual orbital can be reduced by using a perturbative correction. The accuracy of the method can be controlled by a single threshold and is a black box to use. The inclusion of the partial triples correction in the natural orbital based EOM-CCSD method greatly improves the agreement of the results with the experiment. The efficiency of the present implementation is demonstrated by calculating the core-ionization energy of a molecule containing 60 atoms and more than two thousand basis functions.
Terahertz Signatures of the Methane Replacement Reaction in Hydroquinone Clathrates
Authors: Bancroft Katharine , Ajibade Saheed , Koelbel Johanna , Ruggiero Michael , Mittleman Daniel
Published: April 2024

We report a comprehensive experimental and computational study into the low-frequency vibrational dynamics of hydroquinone clathrate during in situ gas loading, in order to monitor the replacement of carbon dioxide with methane in the atomic-level pores of the material. Specifically, terahertz time-domain spectroscopy is utilized, as the terahertz modes are highly-sensitive to the identity and structure of the enclathrated guest molecules. Through the use of ab initio simulations, it was clearly determined that the replacement reaction does not go to completion, and instead we observe the formation of a heterogenous material, with the methane molecules occupying approximately one third of the available adsorption sites. Additionally, while the structure of the methane-hydroquinone clathrate system has been previously determined, our observations suggest that the reported symmetry is incorrect due to methane molecules weakly-interacting with the framework, resulting in dynamic disorder (as opposed to positional disorder) of the guests, unlike the related carbon dioxide clathrate system that is fully-ordered. This work puts us on the path to quantitatively tracking gas loading in porous materials using terahertz spectroscopy.
Performance metrics for tensorial learning: prediction of Li4Ti5O12 nuclear magnetic resonance observables at experimental accuracy
Authors: Harper Angela F , Köcher Simone S , Reuter Karsten , Scheurer Christoph
Published: April 2024

Machine learning (ML) surrogate modeling is a powerful approach to reduce the computational cost of first-principles calculations. While well established for the prediction of scalar observables like energetics or band gaps, performance metrics for the learning of tensor-based observables have not yet been formalized. Here we use the electric field tensor (EFG) underlying nuclear magnetic resonance (NMR) spectroscopy to demonstrate and quantify the superiority of a tensorial learning that fully encodes the corresponding symmetries over a separate scalar learning of individual tensor-derived observables. To this end we establish an extensive EFG data set representative of real experimental applications and develop performance metrics for model evaluation which directly focus on the targeted NMR observables. Our results relate the inferiority of symmetry-agnostic scalar learning especially to its inability to capture the orientation of the EFG tensor. Tensorial learning instead achieves results within experimental precision at a high learning rate.
Osmolyte-Induced Modulation of Hofmeister Series
Authors: Sarkar Susmita , Guha Anku , Narayanan Tharangattu , Mondal Jagannath
Published: April 2024

Natural selection has driven the convergence towards a selected set of osmolytes, endowing them with the necessary efficiency to manage stress arising from salt diversity. This study combines atomistic simulations and experiments to investigate how two osmolytes, glycine and betaine, individually modulate Hofmeister ion ordering of alkali metal salts (LiCl, KCl, CsCl) near a charged silica interface. Both osmolytes are found to prevent salt-induced aggregation of the charged entities, yet their mode and degree of relative modulation depend on their intricate interplay with specific salt-cations. Betaine's ion-mediated surface interaction maintains Hofmeister ion ordering, whereas glycine alters the relative Hofmeister order of cation by salt-specific ion desorption from the surface. Experimental validation through surface-enhanced Raman spectroscopy supports these findings, elucidating osmolyte-mediated alterations in interfacial water structures. These observations based on an inorganic interface are reciprocated in amyloid beta 40 (Abeta40) dimerization dynamics, highlighting osmolyte efficacy in mitigating salt-induced aggregation.
Exploration of Multi-Label Classification Techniques for Modelling of Specialty Arabica Coffee Flavour Notes
Authors: Ho Sherman
Published: April 2024

Predicting the complex flavor profiles of specialty Arabica coffee is a challenging task due to the subjective nature of human sensory evaluations. This study investigates the application of visible-near-infrared (vis-NIR) spectroscopy coupled with multi-label classification techniques to simultaneously predict the presence of flavors described by the Specialty Coffee Association's Flavour Wheel in unroasted green coffee beans. Sixty lots of green coffee beans from various origins were analyzed by vis-NIR spectroscopy, yielding spectral data from 400-1100 nm. Flavour notes for each lot were provided by a commercial coffee roaster based on sensory evaluations, which were binarized as present or absent labels. Nine flavour notes from the Flavour Wheel were modeled: Floral, Honey, Caramel, Fruits, Citrus, Berry, Cocoa, Nuts, and Spice. Exploratory data analysis using principal component analysis and uniform manifold approximation and projection revealed no clear clustering based on flavor notes or origin. However, potential correlations between related flavors on the Flavour Wheel were observed. Several multi-label classification approaches were explored, including binary relevance, classifier chains with various chaining strategies, and decomposed binary classifiers. Model performance was evaluated using Hamming loss and mean balanced accuracy across all labels. The best results were achieved using a decomposed approach by extracting the best-performing binary models for each flavour note from the binary relevance experiments. This yielded a Hamming loss of 0.2778 and a mean balanced accuracy of 69%. Classifier chain methods consistently underperformed, suggesting potential error propagation or that flavour note relationships may not directly translate to taste perception. Independently training binary classifiers achieved low Hamming loss but suffered from overfitting. This study demonstrates the feasibility of using visible-NIR spectroscopy and the potential of multi-label classification to predict the flavor profiles of green coffee beans. With larger datasets and deeper investigations into flavor correlations, these techniques could enable efficient prediction of green coffee beans in the supply chain.
The influence features of individual factors on EU countries’ energy markets
Authors: Honcharenko Vladyslav , Kasyan Svitlana , Filin Anatolii
Published: April 2024

The energy consumption impact is an important factor in the development of countries' economies. The European region is energy-dependent due to a significant shortage of energy carriers and an energy crisis. The energy dependence weakens the energy market and increases its vulnerability to external influences. The subject of research in the article is the characteristics, objective laws, and trends of the development of energy factors that are relative to other influence factors on the economic development of European countries. And the purpose is to analyze and assess important factors influencing the energy markets on the modern economic development of European countries. The task is to analyze the current state of traditional energy resource consumption, to determine the specifics of the impact of energy markets on macroeconomic indicators. To assess the influence degree of energy market indicators on macroeconomic development, which allows to identify the important factors for analysis and to indicate the general position of energy markets in the economy there are used following general scientific methods: systematic, logical and descriptive; analysis and synthesis; statistical; economic-mathematical modeling, namely the construction of a correlation-regression model. Based on the conducted analysis, it was established that the energy markets of the EU have a general feature of increasing dependence, and therefore their sensitivity on external factors, which is associated with a significant decrease in domestic production, as well as a weak differentiation of markets. The production of the main energy resources in Europe has a downward trend for all energy markets, which leads to the increased importance of imports. The influence of energy market factors on the macroeconomic indicators of EU countries is determined. The conducted correlation analysis confirmed the significant impact of the oil market on the GDP growth rate in the EU. The high energy dependence of the EU countries indicates the increased dependence on external factors but no direct correlation between energy dependence and economic development was found. The high dependence of the EU on the import of energy resources is a significant problem, and the energy security factor is also important for investors in the EU. Conclusions: energy factors do not have a significant impact on the development of EU GDP at the current stage, and the quality use of energy resources is more important than their consumption, which emphasizes the importance of efficient use of resources for the further development of the EU economy.
Сreative industry 4.0: trends and transformations in the era of digitalization
Authors: Shkodina Iryna , Kondratenko Natalya , Shchukina Anastasia
Published: April 2024

In the contemporary world, creativity has emerged as a pivotal factor in the development of international economic relations. This article explores the development of the global creative industry 4.0, shaped by the fourth industrial revolution (Industry 4.0). The study aims to examine the trends influencing the creative industries, molded by the intensification of digitization, fostering fundamental changes and transforming them into the creative industry 4.0. The research employs a combination of general scientific and specialized methods, including a systemic approach to justify the main trends in the transformation of creative industries, analysis and synthesis to identify the impact of digital technologies on their evolution, and expert assessment methods to develop approaches for enhancing the development of creative industries 4.0. Results indicate that the digitization of the creative economy has expanded its scale and societal impact. Creative industries are becoming digital not only in terms of services but also in the realm of products. Artificial intelligence, virtual reality, big data, and other digital technologies facilitate the production, scaling, and consumption of creative services and products. The application of digital technologies enhances production efficiency, unlocks unlimited creative potential, improves design, personalization, interactivity, and consumer properties of creative goods and services. The trend of merging entertainment with e-commerce is expected to intensify. The development of the creative economy is crucial for achieving sustainable development goals, stimulating small business growth, and creating new employment opportunities, especially for women, youth, and other vulnerable population groups. The article identifies how Industry 4.0 technologies transform creative industries and proposes ways to leverage these new technological trends for the economic recovery of Ukraine.
Effect of bank’s sizes and age on the financial performance of deposit money banks in Nigeria
Authors: Adewale Abass Adekunle , Shittu Saheed Akande , Adewole Joseph Adeyinka
Published: April 2024

This research explores the impact of bank size and age on the financial performance of deposit money banks in Nigeria. DMB are crucial for allocating funds from savers to investors and managing financial risks. The study aims to determine how bank size and age influence ROA and ROE. Data analysis is conducted using ex post facto research design and panel data analysis. The study reveals a significant strong relationship between bank size and age with ROA and ROE for Nigerian deposit money banks during the period from 2015 to 2021. Increased bank size and age are associated with improved financial performance. The research concludes that bank size and age have a significant impact on the performance of deposit money banks in Nigeria during the specified period. Thus, the study recommends that listed deposit money banks should consider expanding their firm size through strategic expansion initiatives to enhance financial performance. Further research should encompass a broader selection of listed firms in Nigeria and employ diverse analytical tools to validate and expand upon these findings.
Global market of business tourism: development problems and prospects
Authors: Opanashchuk Yuri , Sushchenko Olena
Published: April 2024

An important role in the development of global international tourism is played by business tourism, or corporate tourism, aimed at meeting the needs of business travelers and forming specific trends in the development of the global tourism industry. The study of problems and prospects for the development of the global market of business tourism is aimed at the understanding by market players of its dynamics and the adoption of effective strategic solutions for its future development. The subject of research in the article is the theoretical, methodological and practical aspects of the business tourism global market development. The goal is to analyze the current state and identify trends and prospects for the business tourism global market development. The objective is to research the problems and prospects for the business tourism global market development. General scientific methods are used: systematic analysis - to determine the features of the business tourism global market development, comparative analysis - in the analysis of existing approaches to the definition of business tourism. The following results were obtained: based on the analysis of the dynamics of changes in the main indicators of the business tourism global market, the main problematic aspects and trends of its development were determined. Conclusions: business tourism is one of the most relevant industries for the tourism destination development, as it can bring significant income to the local budget. The process of business tourism development requires prior planning and preparation, including the construction or restoration of infrastructure, which requires cooperation between enterprises of different industries.
СУЧАСНИЙ СТАН РОЗВИТКУ МЕДІАГРАМОТНОСТІ У ПРОФЕСІЙНІЙ ПІДГОТОВЦІ ФАХІВЦІВ ІЗ ЦИФРОВИХ ТЕХНОЛОГІЙ
Authors: Чорна А. В. , Сердюк І. М.
Published: April 2024

Стаття присвячена вивченню сучасного стану розвитку медіаграмотності серед фахівців із цифрових технологій з метою виявлення ключових напрямів, викликів і можливостей для покращення їхньої освітньої підготовки. Праця спирається на застосування теоретичних методів дослідження, що включає аналіз наукової літератури, систематизацію та критичний огляд наявних досліджень у галузі медіаграмотності. У роботі також застосовано методи синтезу для інтеграції знань із різних джерел, оцінку тенденцій і визначення перспективних напрямів розвитку медіаграмотності серед фахівців із цифрових технологій. Дослідження виявило, що сучасний стан розвитку медіаграмотності у професійній підготовці фахівців із цифрових технологій зумовлений технологічними інноваціями, змінами в інформаційному просторі, соціально-культурними трансформаціями, еволюцією освітніх методик, політичними та правовими регуляціями, активною участю зацікавлених сторін та індивідуальними характеристиками. Таким чином, визначається потреба в постійній актуалізації освітніх програм і методик навчання, щоб забезпечити відповідність навчального процесу швидким змінам у цифровому світі та підготувати фахівців, здатних ефективно діяти в умовах глобалізації, технологічного прогресу та медійної розмаїтості. Важливість компонентів медіаграмотності для професіоналів у галузі цифрових технологій полягає в їхній здатності до ефективного аналізу, створення та застосування медійного контенту, що сприяє глибокому розумінню та критичному використанню цифрового контенту. На підставі дослідження встановлено, що всебічна підготовка фахівців у сфері цифрових технологій потребує не тільки глибоких технічних знань, але й розвиненої медіаграмотності. Це передбачає не лише освоєння медійного контенту та технологій, а й уміння критично аналізувати інформацію й етично її використовувати. Дослідження підкреслює необхідність подальших наукових розробок у сфері медіаграмотності, з акцентом на створенні інноваційних освітніх методик за допомогою сучасних технологій та інтерактивних платформ, а також на важливості постійного аналізу її впливу на професійну підготовку з метою адаптації програм до динамічних змін медійного ландшафту та вимог ринку праці.
IMPLEMENTATION OF PRINCIPLES OF INDIVIDUALIZATION AND DIFFERENTIATION IN FOREIGN LANGUAGE CLASSES IN HIGH SCHOOL
Authors: Півкач І. О.
Published: April 2024

The article examines the system and approaches of individualization and differentiation in the process of learning a foreign language in higher education. Determined factors that affect their functioning in the process of working in classes. Separate problems and ways to overcome them are analyzed. Certain opportunities for creating favorable conditions for the development of the creative potential of an individual, development of his thinking and understanding of the ultimate goal and task of learning a foreign language have been identified. Methods and techniques for increasing students’ cognitive activity in classes and strengthening their motivation are illustrated. The article examines the views of scientists N.P. Volkova, G.R. Havryshchak, O.M. Shparyk on individualization and differentiation as dominant and organic components of the educational process. Various approaches to the concepts of differentiation and individualization, as well as concepts related to them, are summarized. The works of these scientists became the theoretical and methodological basis of the conducted research. These principles help to find effective means for teaching a foreign language and learning it effectively. We must not forget that in higher education, the main influence on a student is his mood, curiosity, drive, concentration, surprise. The ability to stimulate the mental states we desire requires a process of individualization and differentiation of each student. A unique approach should be the whole system of education and training of the individual. This article describes the technology of implementing the abovementioned principles in English language classes in higher education. The use of internal differentiation for working in groups and the cluster method for strengthening the cognitive development of each individual when learning a foreign language in higher education are illustrated. The problem of a wide range of possibilities of these principles in the conditions of changes in the system of social relationships, rules of student behavior in the new realities of life is raised. Emphasis is placed on the importance of new requirements for the education system: flexibility, adaptability, feedback, quick response to changes in the social environment, cooperation with psychologists. Considered possible means of organizing students’ work in groups and individually, determined prospects for further research in this direction.
Relationship between Cognitive Impairment and Serum ALP after Light Acute Ischemic Stroke in the Elderly
Authors: Chen Xi , Hou Xiaojun , Fu Hongjuan , Zhang Peng , Huang Yueping , Shi Ying , Xue Jujun
Published: April 2024

Objective: To analyze the association between cognitive impairment and serum ALP levels in elderly patients who developed light acute ischemic stroke. Methods: 100 cases of elderly patients with mild acute ischemic stroke admitted from January 2022 to June 2023 were selected as the study subjects, and were divided into two groups according to whether or not they developed cognitive impairment within six months; those who did not develop cognitive impairment were classified into the control group, with a total of 62 cases, while those who developed cognitive impairment were classified into the case group, with a total of 38 cases. The general data and serum ALP levels of the two groups were compared, and the correlation between serum ALP levels and MoCA scores was analyzed. Results: There was no significant difference between the general information of the two groups of patients in the control group and the case group (P > 0.05). The serum ALP level of the patients in the case group was higher than that of the control group (P < 0.05), and there was a negative correlation between the serum ALP level and the total score of MoCA, the visuospatial and executive scores, and the memory score (P < 0.05). Conclusion: The serum ALP levels of elderly patients with cognitive impairment after mild acute ischemic stroke were higher than those of elderly patients without cognitive impairment after mild acute ischemic stroke, so the risk of cognitive impairment can be predicted in advance by detecting serum ALP levels.
A Review of Chinese Comparative Literature Scholar Professor Jing-Yao Sun’s Research on “Paraliterature”
Authors: Li Qi
Published: April 2024

Professor Jing-Yao Sun, a prominent figure in Chinese comparative literature and a renowned scholar in the field, has made significant contributions to the study of “paraliterature,” an area often overlooked by Chinese scholars. Since the early 1980s, he has been at the forefront of exploring Suzhou Pingtan through a literary perspective. In the 21st century, he emerged as a leading authority in the comparative analysis of “paraliterature,” particularly through his examination of storytelling between China and America. Furthermore, his insightful exploration of the essence of Ion’s oral literary performance and Plato’s misconceptions has paved the way for a deeper understanding of “paraliterature.” Professor Sun’s methodologies have profoundly inspired subsequent generations of comparative literature students in China, motivating them to contribute more to the study of international comparative literature.
Application of Progressive Case Teaching Combined with Scenario Simulation in Comprehensive Practical Teaching of Nursing in Higher Vocational Colleges
Authors: Xu Na
Published: April 2024

Objective: To explore the application of progressive case teaching combined with scenario simulation in the comprehensive practical teaching of nursing in higher vocational colleges. Methods: From September 2023 to November 2023, two groups of students were selected as the research objects. 36 students in the control group adopted the conventional nursing comprehensive practical training teaching method. Based on the conventional teaching method, 37 students in the observation group implemented the progressive case teaching combined with the scenario simulation method. The theoretical and operational test scores of the two groups of students were assessed and compared, and the teaching satisfaction and the score of critical thinking skills of the two groups of students were compared. Results: After the implementation of progressive case teaching combined with the scenario simulation method, the theoretical and operational test scores of students in the observation group were significantly better than those in the control group, with statistical significance (P < 0.05). The teaching satisfaction of the observation group was significantly higher than that of the control group (P < 0.05). The score of critical thinking skills of students in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: The application of progressive case teaching combined with scenario simulation in the teaching of nursing comprehensive practical training of higher vocational can effectively improve students’ theoretical and operational exam scores, promote the cultivation of their critical thinking skills, improve teaching satisfaction, and effectively enhance the quality of talent training for high-quality nursing majors.
Strategies for Applying Schema Theory to Oral English Teaching in Universities
Authors: Yang Qiuping
Published: April 2024

Schema theory is one of the important theories in foreign language teaching. However, there is only a small amount of domestic research that has applied schema theory to oral English teaching. In view of this, based on schema theory, this study analyzes the current situation of oral English teaching and student learning and explores the strategies for applying schema theory to oral English teaching, in the hope that more oral English teachers and learners will use schemata to improve the quality of oral English teaching and learning.
Innovations, Investments, and Sustainable Development of Ecological Technologies
Authors: Tarasenko Valeriia
Published: April 2024

Anthropogenic impact leads to a significant deterioration of the Earth’s ecology, negatively affecting demographic potential and public health. Hence, innovative ecological technologies are necessary to improve this situation. The article explores the development of such technologies in digital ecosystems, highlighting the challenges of their implementation and the problems associated with environmental issues. The author emphasizes the importance of government intervention, creating a favorable environment for investments, and the necessity of collaboration among various stakeholders. This article examined the prospects of integrating environmentally friendly technologies into digital ecosystems and proposed practical approaches to address environmental issues. The scholarly contribution lies in analyzing the connections between digital technologies and ecological sustainability, as well as providing practical recommendations to overcome challenges in this field.
Analisis Kemampuan Numerasi Siswa Sekolah Menengah Atas Ditinjau dari Gaya Belajar
Authors: Karmeliana Dyah Siti , Ladyawati Erlin
Published: April 2024

Tujuan pada penelitian ini yaitu mendeskripsikan kemampuan numerasi siswa sekolah menengah atas ditinjau dari gaya belajar. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif yang melibatkan tiga siswa dengan kemampuan numerasi siswa tinggi dari tiap gaya belajar berdasarkan pada hasil angket dan hasil tes numerasi. Teknik pengumpulan data yang digunakan yaitu menggunakan angket, soal tes numerasi, dan wawancara. Data dianalisis dalam tiga tahap: reduksi data, penyajian data, dan penarikan kesimpulan. Hasil dari penelitian yaitu siswa dengan gaya belajar visual dapat memperoleh informasi dan memahami masalah dengan cara membaca soal terlebih dahulu serta belum terbiasa mengerjakan soal yang berkaitan dengan kehidupan sehari-hari. Siswa dengan gaya belajar auditorial dapat memperoleh informasi dan memahami masalah dengan cara langsung mengerjakan soal secara langsung serta tidak dapat memenuhi indikator kemampuan representasi karena siswa tidak menuliskan dan menyebutkan permisalan yang digunakan untuk menyelesaikan soal, sehingga siswa dapat kebingungan menyelesaikan soal. Siswa dengan gaya belajar kinestetik dapat memperoleh informasi dan memahami masalah dengan cara membaca soal secara berulang serta tidak dapat memenuhi indikator kemampuan representasi karena siswa tidak menuliskan dan menyebutkan permisalan yang digunakan untuk menyelesaikan soal, sehingga siswa dapat kebingungan menyelesaikan soal.
Clinical Impact of Coronavirus Disease 2019 Outbreaks in Korea on Seizures in Children
Authors: Lee Seungjae , Hwang Su-Kyeong , Lee Yun-Jeong , Bae Hyunwoo , Kwon Soonhak
Published: April 2024

Purpose: Coronavirus disease 2019 (COVID-19) can be associated with neurological complications. This study investigated the impact of COVID-19 outbreaks on seizure incidence and duration in children in Korea. Methods: We retrospectively analyzed medical records from Kyungpook National University Children’s Hospital, including 768 children with seizures during the peak COVID-19 outbreaks in March and August 2022, and compared patterns with the same periods in 2021. We examined demographic and clinical characteristics, causes of seizures, underlying conditions, seizure durations, and COVID-19 test results. Results: Out of 16,373,836 COVID-19 cases during the first peak, 25.6% were children (4,184,383), and during the second peak, 20.5% of 6,400,244 cases were children (1,314,331). No significant age differences were observed between either peak and the previous year. However, when compared to the previous year, febrile seizures (FS) were more common during both peaks (25.9% vs. 65.1% in the first peak; 34.3% vs. 59.2% in the second peak). The prevalence of FS was significantly higher in the COVID-19-positive group (84.1%) than in the COVID-19-negative group (51.9%). The incidence of new-onset seizures or breakthrough seizures showed no significant difference. Seizure duration and the incidence of status epilepticus (SE) showed no significant changes, but SE was more common in the COVID-19-negative group (17.1% vs. 6.2%). The clinical features of FS were similar in both groups. Conclusion: COVID-19 appeared to increase the risk of FS in children, but there was no significant impact on the risk of breakthrough seizures or SE in children with epilepsy. Nevertheless, larger-scale studies are necessary.
Um perfil do ensino CTS no Brasil: alguns resultados das pesquisas em teses, dissertações e artigos
Authors: Chrispino Álvaro
Published: April 2024

Este trabalho objetiva apresentar os resultados de pesquisa sobre as Abordagens CTS no Brasil. O banco de dados, iniciado em 2011, reúne 111 Teses de Doutorado, 505 Dissertações de Mestrado e 509 artigos publicados em periódicos qualificados, obtidos em períodos distintos ao longo dos anos. Este trabalho, que é baseado principalmente em estudos de frequência, indica o aumento no número de produções acadêmicas e a alta participação da UFSC e da UNICSUL, sendo possível identificar outras instituições que crescem consistentemente. Dentre os autores mais citados nos estudos, encontramos Wildson Santos e Décio Auler. Registramos baixa contribuição de autores internacionais entre as citações encontradas nos trabalhos catalogados. Os temas de interesse no Brasil, representados pelas palavras-chaves, registram assuntos que representam as disciplinas de estudo, diferentemente dos resultados ibero-americanos e de língua inglesa que identificam temas de interesse sociais.
Variation and λ-jump inequalities on Hp spaces
Authors: Demir S.
Published: April 2024

Let \phi \in S with \int \phi (x) dx = 1, and define \phi t(x) = 1 tn \phi \Bigl( x t \Bigr) , and denote the function family \{ \phi t\ast f(x)\} t>0 by \Phi \ast f(x). Let \scrJ be a subset of \BbbR (or more generally an ordered index set), and suppose that there exists a constant C1 such that \sum t\in \scrJ | \^\phi t(x)| 2 < C1 for all x \in \BbbR n. Then i) There exists a constant C2 > 0 such that \| V2(\Phi \ast f)\| Lp \leq C2\| f\| Hp, n n + 1 < p \leq 1 for all f \in Hp(\BbbR n), n n + 1 < p \leq 1. ii) The \lambda -jump operator N\lambda (\Phi \ast f) satisfies \| \lambda [N\lambda (\Phi \ast f)]1/2\| Lp \leq C3\| f\| Hp, n n + 1 < p \leq 1, uniformly in \lambda > 0 for some constant C3 > 0.
On infinite spectra of oscillation exponents of third order linear differential equations
Authors: Aydamir Khazretovich Stash A. Kh.
Published: April 2024

The research topic of this work is at the junction of the theory of Lyapunov exponents and oscillation theory. In this paper, we study the spectra (i.e., the sets of different values on nonzero solutions) of the exponents of oscillation of signs (strict and nonstrict), zeros, roots, and hyperroots of linear homogeneous differential equations with coefficients continuous on the positive semi-axis. In the first part of the paper, we build a third order linear differential equation with the following property: the spectra of all upper and lower strong and weak exponents of oscillation of strict and non-strict signs, zeros, roots and hyper roots contain a countable set of different essential values, both metrically and topologically. Moreover, all these values are implemented on the same sequence of solutions of the constructed equation, that is, for each solution from this sequence, all of the oscillation exponents coincide with each other. In the construction of the indicated equation and in the proof of the required results, we used analytical methods of the qualitative theory of differential equations and methods from the theory of perturbations of solutions of linear differential equations, in particular, the author’s technique for controlling the fundamental system of solutions of such equations in one special case. In the second part of the paper, the existence of a third order linear differential equation with continuum spectra of the oscillation exponents is established, wherein the spectra of all oscillation exponents fill the same segment of the number axis with predetermined arbitrary positive incommensurable ends. It turned out that for each solution of the constructed differential equation, all of the oscillation exponents coincide with each other. The obtained results are theoretical in nature, they expand our understanding of the possible spectra of oscillation exponents of linear homogeneous differential equations.
On undecidability of unary non-nested PFP-operators for one successor function theory
Authors: Sekorin V. S.
Published: April 2024

We investigate the decidability of first-order logic extensions. For example, it is established in A. S. Zolotov’s works that a logic with a unary transitive closure operator for the one successor theory is decidable. We show that in a similar case, a logic with a unary partial fixed point operator is undecidable. For this purpose, we reduce the halting problem for the counter machine to the problem of truth of the underlying formula. This reduction uses only one unary non-nested partial fixed operator that is applied to a universal or existential formula.
INVESTIGATION OF BIOCHEMICAL CHANGES IN BLOOD AND SALIVA OF BASKETBALL PLAYERS BEFORE THE COMPETITION
Authors: P.I. Aydinova  , N.A. Musayeva  , A.A. Mekhtiev
Published: April 2024

Much research has been conducted to understand how anxiety can affect sports performance, both in practice and in development. It is known that exercise is associated with high levels of stress and threat potential, and the application and application of a number of psychological strategies can be beneficial in managing anxiety. The article is devoted to the evaluation of the level of dihydropyrimidinase-like protein 2 (DBZ2) in platelets and saliva of basketball players before the competition and the level of natural autoantibodies against DBZ2 in blood serum. Instead of control, samples of blood and saliva from those athletes in normal condition were used. The levels of DBZ2 and natural autoantibodies against DBZ2 were determined by indirect immuno-enzymatic assay on polystyrene tablets with a moderate level of adsorption. The results of the research showed a significant decrease in the level of natural autoantibodies against DBZ2 in the serum of the athletes before the competition (p < 0.01) and no changes of DBZ2 in their platelets and saliva. Based on the evidence obtained in previous years, our results allow us to conclude that athletes reflect similar changes in the level of DBZ2 in the subcortical regions of the brain and indicate an increase in their level of aggression before competition.
ВОВЛЕЧЕНИЕ ДЕТЕЙ С ОВЗ В АДАПТИВНЫЙ СПОРТ
Authors: D.S. Ibrahimova
Published: April 2024

Данная научная статья посвящена вопросу вовлечения детей с ограниченными возможностями здоровья в адаптивный спорт. В статье анализируются преимущества, которые спортивная активность может принести детям с ОВЗ, а также рассматриваются проблемы и вызовы, связанные с организацией адаптивного спорта для этой категории детей. Большое внимание уделяется вопросам создания условий для участия детей с ограниченными возможностями в адаптивном спорте, таких как доступность инфраструктуры, обучение тренеров и волонтеров, создание безопасных условий для занятий спортом. Также рассматривается важность поддержки со стороны общества и государства для развития адаптивного спорта для детей с ограниченными возможностями. В статье приводятся примеры успешных практик и программ в разных странах мира, которые могут послужить примером для развития адаптивного спорта и улучшения условий участия детей с ограниченными возможностями в спортивной жизни общества.
Rapid preconcentration and determination of Co (II) ions in aqueous medium using ultrasound assisted cloud point extraction method
Authors: Sürme Yavuz , Kahve Yıldırım Gizem , Uçan Mustafa , Narin İbrahim
Published: April 2024

A flame atomic absorption spectrophotometric technique was studied for the preconcentration and determination of of Co2+ ions in trace amounts after ultrasound enhanced enrichment of its 1-(2-pyridylazo)-2-naphthol (PAN) complexes by cloud point extraction. The Co2+ ions were firstly complexed with PAN molecules at pH 4 and the complex transferred to a surfactant (Tergitol NP-7) rich phase with a very small volume under ultrasound waves. The surfactant rich phase was separated and dissolved by 1 mL, 1.0 M HNO3 in ethanol prior to determination of Co2+ concentration by flame atomic absorption spectrophotometry. The optimization steps of ultrasound interaction time, solution pH and surfactant volumes were achieved by response surface methodology (RSM) which is a combination of statistical approaches. Sample volume, PAN concentration and and possible interfering ions were optimized conventionally. The Co2+ ions were extracted only in 150 s at pH 4 quantitatively under optimum conditions (˃95%). The accuracy and validity of developed UA-CPE was granted by employing a certified reference material wastewater UME CRM 1204. The technique was applied to wastewater and natural water with satisfactory results.
BORSA ENDEKS YÖNÜNÜN AĞAÇ TABANLI TOPLULUK MAKİNE ÖĞRENMESİ YÖNTEMLERİ İLE TAHMİNİ: BİST-100 ÖRNEĞİ
Authors: Büyükkör Yasin , Doğan Seyyide
Published: April 2024

Borsa endeks yönünün tahmininde finansal verilerin karmaşık ve durağan olmayan yapısı nedeniyle etkin bir tahmin modelinin kurulması oldukça zordur. Bazı dışsal faktörlerin ve şokların etkilerinin daha derin gözlendiği gelişmekte olan ülke borsalarında, borsa endeksinin aşağı veya yukarı yönlü hareketini tahmin etmek gerek yatırımcılar, hükümetler, finansal kurumlar ve kreditörler gibi paydaşlar gerekse de araştırmacılar için önemli bir konudur. Bu çalışmanın amacı, Borsa İstanbul 100 (BİST-100) endeksinin borsa endeksinin yönünü ağaç tabanlı topluluk Makine Öğrenmesi (ML) yöntemleriyle tahmin etmektir. Üç yılın günlük Açılış, Kapanış, En Yüksek, En Düşük ve Hacim verilerine Üstel Düzgünleştirme uygulandıktan sonra hesaplanan Teknik Göstergeler modelin girdi değişkenleri olarak ele alınmıştır. Ayrıca Teknik Göstergelerin pencere uzunlukları artırılarak girdi değişkeni uzayı genişletilmiştir. Çalışmada Karar Ağaçlarına dayanan topluluk makine öğrenmesi yöntemlerinden Random Forest, XGBoost ve CatBoost kullanılmıştır. Modelin parametreleri Bayesyan Arama (Bayesian Search) yöntemi ile optimize edilmiştir. Çalışmanın bulgularına göre, tercih edilen bütün yöntemler %89,7 ile %90,4 aralığında doğruluk oranına sahipken ve diğer performans değerlendirme kriterleri de dikkate alındığında en iyi performansa sahip yöntemin XGBoost olduğu görülmektedir.
Efektifitas Bioporidrainase sebagai Resapan Air
Authors: Hakim Abdul
Published: April 2024

Perkembangan kota yang terus meningkat dengan pesat dan rendahnya ruang terbuka hijau menyebabkan ketersediaan permukaan tanah untuk infiltrasi air tanah semakin berkurang. Sebaliknya air runoff mempengaruhi terjadinya genangan air di dalam kampus UIN Sunan Ampel Surabaya pada saat musim penghujan.  Tujuan penelitian ini adalah untuk mengetahui berapa tinggi genangan di dalam saluran drainase dengan nilai gradien hidrolik yang rendah dan untuk mengetahui kemampuan permukaan tanah dalam menyerap air. Beberapa tes laboratorium dilakukan seperti: tes propertis tanah, permeabilitas dan tes infiltrasi pada 5 (lima) saluran drainase. Hasil dari penelitian ini menunjukkan bahwa saluran C-D memerlukan 16 biopori, saluran K-M memerlukan 5 (lima) biopori, saluran M1-M dan P1-Q1 memerlukan 12 biopori. Selanjutnya saluran Q-T memerlukan 30 biopori untuk meresapkan air ke dalam tanah dengan efektif.
Kata kunci: Bioporedrainage, resapan air, Limpasan.
Dekontaminasi Parameter Biologi dan Pathogen Menggunakan Biofilm Konsorsium Bergerak Dilanjutkan dengan Intergrasi Pengolahan Fisik (Pengendapan-Sterilisasi) Secara Simultan
Authors: Novembrianto Rizka , Murti Restu Hikmah Ayu , Rhomadhoni Muslikha Nourma
Published: April 2024

Banyaknya air limbah domestik tanpa pengolahan terlebih dahulu dibuang ke air badan air sehingga dirasa semakin hari kualitas menjadi menurun. Kandungan organik dan mikroorganisme menjadi perhatian dalam segi kualitas. Tingginya kandungan organik dan mikrooorganisme seperti Total coliform. Penurunan parameter tersebut sebagai tujuan utama dalam penelitian ini. Pada proses aerob, pengolahan organik menggunakan pasokan udara sebesar 20 L/menit pada pengolahan secara tersuspensi dan terlekat untuk media terlekat menggunakan media kaldnes K5 dan bioball berduri masing-masing 30 % dari volume reaktor yang didahuili proses seeding dan aklimatisas. Variasi waktu pengolahan yang digunakan adalah tersuspensi 2 jam dan terlekat selama 6 jam serta sebaliknya. Selanjutnya diolah dengan pengolahan secara fisik secara simultan yakni proses pengendapan dan sterilisasi dengan waktu paparan dan pengendapan yakni 2 hingga 6 jam. Berdasarkan hasil penelitian menunjukkan hasil seeding dan aklimatisasi dilakukan selama 21 hari. Didapatkan pengolahan terbaik menggunakan tersuspensi 2 jam, terlekat 6 jam pada media kaldnes K5 dan pengendapan sekaligus paparan sinar ultraviolet selama 6 jam menunjukkan hasil penurunan COD sebesar 92,85 % dan untuk Total coliform sebesar 98,67 %. Kata Kunci: domestik, organik, media, ultraviolet
Evaluasi Pengelolaan Sampah Kecamatan Gresik Kabupaten Gresik Ditinjau Dari Aspek Teknis
Authors: Fardi Habibi Mohammad , Hadi Wahyono , Ni'am Achmad Chusnun
Published: April 2024

Pengelolaan sampah merupakan tantangan serius bagi pemerintah dalam mengambil kebijakan, sehingga dibutuhkan pengelolaan sampah yang terintregasi dan berkelanjutan. Kabupaten Gresik merupakan salah satu daerah yang mendukung perkembangan kota Surabaya sehingga mengalami pertumbuhan disegala sektor secara pesat. kondisi kapasitas sel sampah TPA Ngipik yang melayani kecamatan Gresik telah mengalami overload. Permasalahan dalam penelitian ini yaitu bagaimana pengelolaan sampah dikecamatan Gresik ditinjau dari aspek teknis dengan evaluasi yang mengacu pada paraturan perundang – undangan tentang persampahan yang berlaku, sehingga diperoleh tujuan penelitian dengan cara menganalisis aspek teknis. Penelitian ini menggunakan metode data kuantitatif dan data kualitatif kemudian dianalisis dengan melakukan tinjauan terhadap aspek yang berkaitan dengan keabsahan kondisi eksisting menurut standar normatif dan teori pengelolaan sampah. Dari hasil evaluasi diperoleh sebagai berikut Tingkat pengurangan sampah belum mencapai 30% dan layanan persampahan di Kecamatan Gresik sebesar: 100 %, masih sedikitnya kesediaan pewadahan terpilah, masih ada TPS tanpa atap, pengangkutan sudah memenuhi namun armada dan kontainer masih ada yg kurang layak, lokasi TPA Ngipik layak berdasarkan SNI 03-3141-1994.