bluuebunny/crossref_metadata_2025 huggingface dataset:
Analgesic efficacy of Transverse thoracic muscle plane block (modified approach) in off-pump coronary artery bypass grafting : A retrospective cohort study
Authors: ZHANG Xiao-yan , ZHANG Yu , SUN Ying-jie , FAN Hong-na , DIAO Yu-gang
Published: September 2022

Background:To investigate the safety and effectiveness of bilateral transverse thoracic muscle plane (TTP) block (modified approach) combined with general anesthesia in off-pump coronary artery bypass grafting (OPCABG). Methods :The clinical data of 60 patients undergoing OPCABG, selected from March to August 2021 in general hospital of northern theater command, were retrospectively analyzed and divided into TTP block with general anesthesia group ( group T, n=30) and general anesthesia group (group G, n=30) according to anesthesia mode. Patients in group T undergone bilateral TTP block (modified approach, 0.25% ropivacaine 20 ml each side) before anesthesia induction, and both groups were induced by routine anesthesia. The mean arterial pressure (MAP) and heart rate (HR) were recorded and analyzed before and after cutting, splitting and closing the sternum, and the total dosage of sufentanil at the end of operation was recorded. The levels of lactic acid and blood glucose were detected with blood gas analysis before the operation , at the end of the operation, and at 2 h, 4 h, 6 h, 8 h, 10 h, 12 h, 16 h, 20 h and 24 h after the operation. The visual analogue scale (VAS) scores in resting and moving state were recorded at 12 h, 24 h and 48 h after operation. The numbers of patients who were first added analgesic drugs (pethidine) on the day, the first day and the second day after operations were recorded, and the occurrence of postoperative adverse reactions was recorded. Results: Compared with group G, the change rate of MAP and HR in group T decreased slightly at each time point, but the difference was not statistically significant (P>0.05). The levels of lactic acid at 2 h and 4 h after operation and the levels of blood glucose at 2 h, 4 h and 6 h after operation were significantly lower than those of group G (P<0.05). Compared with group G, the VAS scores (resting and moving state) of group T significantly decreased at 12 h (resting state) after operation (P<0.05). Compared with group G , the extubation time of group T was shorter, but with no statistical significance (P>0.05); while the dosage of sufentanil in group T was obviously decreased, and the number of patients who were added analgesics at the postoperative day was markedly reduced (P<0.05). The incidence of postoperative chills was obviously lower in group T than in group G (P<0.05). No significant difference existed between the two groups in the incidence of postoperative nausea and vomiting, arrhythmia, pruritus, abdominal distention and infection in operation area 3 days post operation (P>0.05). Conclusion: Bilateral TTP block (modified approach) combined with general anesthesia can provide good perioperative analgesia for patient undergoing OPCABG, reduce the use of opioids, and inhibit the stress response to a certain extent, thus having better safety and effectiveness.
The Prevalence of Musculoskeletal Pains among Healthcare Workers
Authors: Arianezhad Ali , Khorramizadeh Maryam , Kord Zaynab , Norouzi Ali , Zarasvand Behrooz
Published: September 2022

Background and Objectives: Musculoskeletal pains refer to damages people with inappropriate body positions may suffer in their jobs and are one of the most common occupational diseases.With hospital personnel and those working in this environment like physicians, nurses, interns and nursing apprentices falling into active occupational groups, this study sought to determine the prevalence of musculoskeletal pains in these occupations.Method: This descriptive-analytical cross sectional study was conducted in Dr. Ganjavian Hospital in Dezful in 2020 on 239 physicians, nurses, interns and nursing apprentices using a random sampling method. To assess musculoskeletal disorders in people, the Nordic Musculoskeletal Questionnaire (NMQ) was used. The data normalization was examined using chi-squared test and contingency tables. The whole analyses were done by SPSS 16.Results: Musculoskeletal pains in people with higher job and study-related activities were more prevalent than other people in the study. There was also a significant relationship among gender, median age, the frequency of exercise and BMI with the prevalence of musculoskeletal pains. A significant relationship was found between different occupational groups (physicians, nurses, interns and nursing apprentices) and the presence of pain in wrists, hands and elbows, too.Conclusions: Our results showed that the presence of musculoskeletal disorders was relatively high in the lumbar regions (51.7%) and necks (49.6%) and in general musculoskeletal disorders are significantly higher among physicians and nurses, a reason of which can be related to a higher median age in these groups than in apprentices. Thus, it seems necessary to both improve working conditions for hospital staff and raise their awareness of the risks leading to musculoskeletal disorders.
Bayesian probabilistic approaches for predicting the debris-flow sediment volume using limited site investigation data
Authors: Tian Mi , Xiong Zimin , Li Lihua , Sheng Xiaotao
Published: September 2022

Many empirical relationships have been proposed to relate the sediment volume to various influencing factors. However, the accuracy of such empirical relationships generally requires a large number of observation data, which is difficult to be guaranteed at a specific site. Moreover, based on the limited investigation data, a complicated empirical model with more input factors may be an overfitted equation. Therefore, how to develop a reliable prediction model of debris-flow sediment volume still remains a great challenge. This paper develops a robust method to establish the most appropriate model for predicting the debris-flow volume based on Bayesian inference. Firstly, the limited site investigation data are preprocessed by a series of multicollinearity analysis to select the candidate input variables. Then, a Bayesian framework is developed to select the most appropriate model among alternatives and identify its corresponding model parameters based on the site investigation data and prior knowledge. To address the multi-dimensional issues in Bayesian inference, a multi-chain method, specifically DREAM(ZS) algorithm, is used to obtain the posterior distribution of model parameters of a candidate model to overcome the inefficient sampling problems of single-chain Markov chain Monte Carlo (MCMC) methods (e.g., Metropolis-Hastings algorithm). MCMC samples of model parameters are subsequently applied to calculate the evidence of a candidate model using Gaussian copula, making the DREAM(ZS) algorithm feasible in model selection problem. Results show that compared with the pre-existing empirical relationship, the proposed approaches provide a simpler and more accurate model by reasonably considering the balance between data fitting and model uncertainty.
A tool-box strategy for layer-by-layer assembly of ultrathin hybrid films from graphene oxide and chromophores for organic electronics
Authors: Gusarova Elizaveta A. , Zvyagina Alexandra I. , Aleksandrov Alexey E. , Averin Alexey A. , Tameev Alexey R. , Kalinina Maria A.
Published: September 2022

A combinatorial interfacial assembly method was developed for fabrication functionally different 2D hybrids by using the same starting set of components comprising graphene oxide, perylene chromophore, polydiacetylene surfactant and nickel nitrate as a source of divalent ions. The components were assembled through either hydrogen or coordination bonding into layered nanofilms with a thickness 8-20 nm to integrate them into conventional ITO-based solar cells. Depending on their composition, the hybrids provide different operational characteristics to the resulting devices. The combination of graphene oxide with the light-absorbing polymer provides photovoltaic properties, whereas the adding of nickel transforms the hybrid into the monopolar conductive layers. The combination of two chromophores gives a multipurpose nanoelement, which performs as either non-linear resistor, diode or photodiode. This strategy can be easily extended to other combinations of chemical tools for the design of various hybrid nanofilms with desirable functional properties for organic electronics.
Facile Constructing Inorganic Phosphorus/boron-layered Double Hydroxide Complexes for Highly Efficient Fire-safety Epoxy Resin
Authors: Shao Zhu-Bao , Wang Tian-Ci , Song Xiang , Cui Jing , Zhu Longxiang , Lin Xue-Bao
Published: September 2022

Concerning inorganic flame retardants, the facile fabrication and high-efficiency fire safety without compromising the mechanical property of matrix are still significant challenges. Here, nano-layered double hydroxide containing boron constructed on the surface of ammonium polyphosphate complexes (B-LDH@APP) is prepared by a simple in-situ coprecipitation technology to reduce the fire hazard and improve mechanical performances of epoxy resin (EP). The as-obtained 4B-LDH@APP/EP achieves the UL-94 V-0 rating and presents superior flame-safety performance. With respect to the 4APP/EP, the fire growth rate, the peak heat release rate, and the peak smoke production rate of 4B-LDH@APP/EP decrease by 77.8%, 57.3%, and 52.6%, respectively. The reason is mainly contributed to excellent synergistic flame-retardant effect among boron, LDH, and APP, which can accelerate the generation of compact charring residual with good microstructure during combustion of B-LDH@APP/EP composites. Furthermore, B-LDH@APP slightly affects the mechanical performances of EP matrix due to the upgraded interfacial interaction.
A novel image encryption scheme for DNA storage systems based on gene hybridization and gene mutation
Authors: Yao Xiangyu , Xie Ranze , Zan Xiangzhen , Su Yanqing , Xu Peng , Liu Wenbin
Published: September 2022

With the rapid development of DNA (Deoxyribonucleic Acid) storage technologies, storing digital images in DNA is feasible. Meanwhile, the information security in DNA storage system is still a problem to solve. Therefore, in this paper, we propose a DNA storage-oriented image encryption algorithm utilizing the information processing mechanisms in molecule biology. The basic idea is to perform pixel replacement by gene hybridization, and implement dual diffusion by pixel diffusion and gene mutation. The ciphertext DNA image can be synthesized and stored in DNA storage system after encryption. Experimental results demonstrate it can resist common attacks, and shows a strong robustness in against sequence loss and base substitution errors in the DNA storage channel.
Phase transformation induced high-strength titanium carbide reinforced stainless steel composites with stable thermo-mechanical properties for high temperature applications
Authors: Cho Seungchan , Kim Junghwan , Lee Jihye , Shin Sangmin , Lee Donghyun , Kim Minsoo , Hong Hyun-Uk , Choi Moonhee , Lee Yoon-Seok , Jo Ilguk , Lee Sang-Kwan
Published: September 2022

The high-temperature properties such as the tensile strength, hardness, coefficient of thermal expansion (CTE), and thermal conductivity of titanium carbide (TiC)-reinforced stainless steel (SS) matrix composites fabricated by the infiltration process were investigated at various temperatures. Highly concentrated, closely adjacent TiC particulate reinforcement effectively suppressed dramatic variations in the CTE and thermal conductivity properties originating from the phase transformation of the SS431 matrix with superior mechanical properties. The strengthening effect of the addition of TiC increased as the temperature increased and showed a higher value after the phase transformation. The TiC–SS431 composite showed great applicability for advanced high-temperature-resistant structural materials.
Ocean response to Tropical Cyclone “Asani”: Surface cooling restricted by Coastal Downwelling
Authors: Ray Sthitapragya , Moharana Sidha Sankalpa , Swain Debadatta
Published: September 2022

The severe cyclonic storm “Asani” formed in the southeastern Bay of Bengal on 6th May 2022 and made landfall on the evening of 11th May 2022 in Andhra Pradesh, India. The unique characteristic of this cyclone was its low TS from roughly 27 hours prior to its landfall resulting in a remarkably prolonged interaction with the coastal ocean. In this analysis, we examined the sea surface temperature (SST) response to the cyclone at three locations along its track and analyzed the temporal variation of the observed cyclone-driven SST cooling. Four different ocean processes (wind-stirred and buoyancy flux-driven mixing, windstress-curl and alongshore windstress driven upwelling) could be identified by the corresponding proxies as the drivers of this cooling. A SST cooling of 1.08 °C was observed over a two-day period around the genesis area. Ekman pumping and wind-stirred mixing illustrated high values over the maximum intensity region during the passage of the cyclone, resulting in a SST drop by 2.14 °C. The landfall area had a significantly longer duration of interaction with the cyclone, as its TS reduced from moderate to slow, exhibiting wind-stirred mixing values comparable to the other two regions. However, the SST drop was the lowest at ~0.65 °C. Coastal downwelling-favourable windstress associated with the leading edge of the cyclone was responsible for limiting the cooling that could have otherwise resulted from mixing and entrainment. This unique modification of cyclone-ocean interaction through coastal upwelling possibly delayed the dissipation of cyclone “Asani”.
β-cypermethrin and essential oils incorporated into a single nanoformulation: chemical and biological characterization
Authors: Jesser Emiliano Nicolas , Yeguerman Cristhian Alan , URRUTIA Rodrigo Iñaki , MURRAY Ana Paula , Domini Claudia , González Jorge Omar Werdin
Published: September 2022

This work developed and evaluated the toxicological effects of single nanoemulsions (NEs) of peppermint or palmarosa essential oils (EO) combined with β-cypermethrin (CP) using ultrasound technique. For NEs formulation ultrasound parameters were: ultrasound power = 65 W, sonication time = 2 min and cycles = 30 on/20 off. The optimized active ingredients:surfactant ratio was 1:2. The NEs of peppermint EO combined with CP showed two peaks at 12.77 (33.4% intensity) and 299.1 nm (66.6% intensity) and polydisperse index (PDI) values of 1, while the NEs of palmarosa EO combined with CP had a size of 104.5 nm and their PDI value, 0.220. Both NEs were transparent and they were stable for 2 months. The insecticidal effect of these NEs (active ingredients:surfactant ratio was 1:2) were evaluated against T. castaneum and S. oryzae adults and Cx p. pipiens larvae. The NEs of peppermint EO combined with CP showed an enhancement of bioactivity of β-CP between 4.22 and 16 folds, while NEs of palmarosa EO + CP between 3.90 and 10.6 folds in all these insects. Moreover, both NEs demonstrated high insecticidal activity in all insect for 2 months, although slightly increase of particle size was detected. In this regard, the NEs elaborated in this work can be considered as highly promising formulation for the development of new insecticides.
The Kangjiapo landslide in Wanzhou district, Chongqing city: reactivation of a deep-seated colluvial landslide in the Three Gorges Reservoir
Authors: Xie Xiaoxu , Li Deying , Miao Fasheng , Yan Liangxuan , Leo Chin , Yiqing Sun
Published: September 2022

How to reduce landslide risk economically and effectively is a very meaningful and challenging research topic. In particular, it is difficult and expensive to completely control deep-seated colluvial landslides. Taking the Kangjiapo landslide in Wanzhou district, Chongqing city, China as a case, this study focuses on measures to prevent and control the risks of deep-seated colluvial landslides through detailed investigation and monitoring. The Kangjiapo landslide is located in the Three Gorges Reservoir area, and it is part of a famous ancient landslide named the Pipaping landslide. The steep sliding surface in the rear was not found during the first treatment, the Kangjiapo landslide has been reactivated since 2015. Field investigations, monitoring, borehole and related test were conduct to identify the landslide characteristics and mechanisms. The landslide deformation was not spatially or temporally uniform according to monitoring data analysis. The landslide is less likely to fail in general because the sliding surface in the front is very gentle. The reasons for Kangjiapo landslide reactivation could include the decline of the reservoir water level, a steep sliding surface in the rear, the existence of a sliding zone with low strength due to a long period of reservoir immersion. Landslide risk mitigation measures are proposed for the deep-seated landslide, including stabilizing piles nearby the road, and a BeiDou Navigation Satellite System and MEMS inclinometers in the platform.
Zinc finger DHHC-type palmitoyltransferase 12 is a potential prognostic biomarker in glioma
Authors: Xu Haitao , Chen Xi , Niu Xiaoqun , Pu Jun
Published: September 2022

Background
Zinc finger aspartate - histidine - histidine - cysteine (DHHC) - type palmitoyltransferase 12 (ZDHHC12) is reportedly involved in neuropsychiatric diseases. However, the biological function and mechanism of ZDHHC12 in glioma remain to be further explored. Hence, this study aimed to investigate the associations between ZDHHC12 expression and prognosis and tumor progression in glioma.
Methods
We utilized the cancer genome atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases to explore the expression level and prognostic value of ZDHHC12 in glioma. Furthermore, GO, KEGG and GSEA enrichment analysis were used to examine the function of ZDHHC12 in glioma. The ESTIMATE and ssGSEA algorithms were used to explore the correlations between ZDHHC12 expression and tumor-infiltrating immune cells. Finally, immunohistochemistry, growth curves, EdU, Transwells and wound healing assays were used to examine the biological function of ZDHHC12 in glioma cell lines.
Results
Higher expression of ZDHHC12 was correlated with adverse clinical features, including tumor grade, IDH status, 1p/19q depletion, histological type and patient age. Moreover, increased ZDHHC12 expression was associated with poorer overall, disease-specific, and progression-free survival. ZDHHC12 expression was strongly associated with immune cell infiltration in glioma. Importantly, ZDHHC12 was highly expressed in glioma tissues and depletion of ZDHHC12 significantly inhibited glioma cell proliferation and migration and promoted glioma cell apoptosis in vitro.
Conclusion
We found that ZDHHC12 was upregulated and could act as a poor prognostic biomarker in glioma. Importantly, ZDHHC12 expression was associated with the immune infiltration levels of immune cells in glioma. In addition, depletion of ZDHHC12 significantly inhibited glioma cell proliferation and migration and promoted glioma cell apoptosis in vitro. These findings suggested that ZDHHC12 might be a potential biomarker for evaluating prognosis and immune infiltration in glioma.
Lipid droplets’ functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasia
Authors: Chen Xiao-Jie , Bai Yu-Ting , Xie Ji-Rong , Zhou Gang
Published: September 2022

Background: The function of lipid droplets (LDs) has not been clarified in precancerous lesions, and the relationship between LDs, lipid metabolism, and epithelial-mesenchymal transition (EMT) remains unclear in the carcinogenesis processes in the oral cavity.Methods: Tissue frozen sections were collected for oil red O staining of LDs. Forty-eight oral squamous cell carcinomas (OSCC), 78 oral potentially malignant disorders (OPMDs), and 25 normal paraffin-embedded tissue sections were included to explore the LDs surface protein caveolin-2 and perilipin-3, lipid metabolism-related molecule fatty acid binding protein 5 (FABP5), and EMT biomarker E-cadherin expression by immunohistochemical staining. Results: The accumulation of LDs was observed in OPMDs and OSCCs compared to normal tissues (P < 0.05). In general, an increasing trend of caveolin-2, perilipin-3, and FABP5 expression was detected from the normal to OPMDs to OSCC groups (P < 0.05); however, the increased level of perilipin-3 was not significant in OPMDs compared to the normal controls (P > 0.05). In addition, caveolin-2, perilipin-3, and FABP5 expression were positively correlated with epithelial dysplasia in OPMDs, whereas E-cadherin positivity was negatively correlated with epithelial dysplasia and histopathological grade in OPMDs and OSCC, respectively. A negative correlation of caveolin-2 (P < 0.01, r = - 0.1739), and FABP5 (P < 0.01, r = - 0.1880) with E-cadherin expression was detected. The caveolin-2 (P < 0.0001, r = 0.2641) and perilipin-3 (P < 0.05, r = 0.1408) staining was positively correlated with FABP5. OSCC local recurrence was associated with high expression of caveolin-2 (P < 0.05) and FABP5 (P < 0.05), and lymph node metastasis was associated with high FABP5 expression (P < 0.05) but low E-cadherin expression (P < 0.05). The caveolin-2 high expression group had a worse disease-free survival (DFS) (P < 0.05). Conclusion: In the oral epithelial carcinogenesis process, LDs begin to accumulate early in the precancerous stage. LDs may be the regulator of FABP5-associated lipid metabolism and are closely related to the process of EMT; caveolin-2 could be the main functional protein, indicating that caveolin-2 is a potential biomarker for oral carcinogenesis and prognosis.
A Semiautonomous Approach for Strategic Decision-Making; an Application for Digital Transformation in Finance
Authors: Sarvari Peiman Alipour , Martin Sebastien , Grybauskas Andrius , Baskurt Gulcan
Published: September 2022

This paper proposes an innovative approach to help domain knowledge experts with technology roadmapping and the strategic decision-making process. In our approach, we introduce a retrofitted parallel coordinate visualization tool, which is enhanced with a feature importance analysis algorithm. Our approach has produced four significant achievements. First, our new method reveals the shortcomings of some traditional parallel coordinate tools. Second, our method applies neutrosophic fuzzy sets in tacit knowledge analysis to foster ease with written text data; it assists with the processes in exploring possible roadmapping strategies, measuring vicinity conditions of adjacent features, and prioritizing their order based on the desired solution space of a certain attributes. The methods are applied in a case study with actual data that comes from a research project designed for financial organizations’ digitalization. Third, the application of parallel coordinates is reported for the first time for technology roadmapping in finance. Finally, proof of concept and a benchmarking practice considering generated hypotheses are provided in this paper.
Does Mechanical Bowel Preparations really prevent infective complications after colorectal surgery? Is a Myth or Fact? Mechanic Bowel Preparations: Is a Myth or Fact?
Authors: BENLİ Sami , TİKİCİ Deniz , BAYSAN Caner , Türkmenoğlu Mehmet , Çolak Tahsin
Published: September 2022

Purpose: Despite mechanical bowel preparation (MBP) was routinely used before elective colorectal surgery in most of surgical clinics, using MBP remains controversial. This study aimed to investigate the postoperative infectious complications and outcomes of right, left or rectosigmoid resection without MBP and compare with each other.Methods: Patients who underwent elective colorectal surgery without mechanical bowel preparation between January 2011 and December 2021 were included in the study. Patients were categorized according to the side of resection (right, left and rectosigmoid resection), and these subgroups compared for the anastomotic leakage and surgical site infections (SSI) and overall morbidity measured using the Clavien-Dindo classification Results: The data of 422 patients who met the study criteria were analyzed. There were 152 (36%) patients in the right colectomy group, 106 (25.1%) patients in the left colectomy group, and 164 (38.9%) patients in the rectosigmoid resection group. Overall anastomotic leakage was found in 14 (3.3%), SSI was in 46 (10.9%), the collection was in 14 (3.3%), mortality was 18 (4.3%), and reoperation was in 17 (%4) patients. Anastomotic leakage was observed in 6 (3.9%) in the right colectomy, 2 (1.9%) in the left colectomy, and 6 (3.7%) patients in the rectosigmoid resection group when the groups were evaluated separately. There was no statistical difference between the groups (p=0.630). Considering the mortality rates, it was found to be higher in the right colectomy group compared to the other groups, and the p value was 0.003. Furthermore, there was no statistical difference between the groups regarding collection, and reoperation; p values were p=0.31, and p=0.251, respectively.Conclusion: There was no increase in anastomotic leakage, surgical site infection, intra-abdominal collection, reoperation, and mortality rates in patients undergoing colorectal surgery without MBP. In addition, these results were not changes for right, left or rectosigmoid resection sub-groups.
Synthese heteroatom-dotierter Phenalene
Authors:   , Massoth Julian Gerhard
Published: September 2022

In dieser Arbeit konnte 1,8-Diborylnaphthalin (11) präparativ in einer Stufe und 65% Ausbeute aus dem literaturbekannten Boronsäureanhydrid 9 dargestellt werden. 11 ist das zweite bekannte, aromatisch verbrückte Derivat des Diborans B2H6. 11 kann als Startverbindung für eine Reihe strukturverwandter BNB-dotierter Phenalenderivate verwendet werden. Dazu werden zwei der vier Bor-gebundenen Protonen durch die Umsetzung mit einem Mesitylgrignard und Trimethylsilylchlorid substituiert. Die Umsetzung mit Wasser bzw. Aminen liefert BOB- bzw. BNB-Phenalene unter Freisetzung von elementarem Wasserstoff. Alle, auf diese Weise dargestellten Verbindungen, zeigen reversible Redoxeigenschaften und Photolumineszenz mit zum Teil besonders scharfen Emissionssignalen mit Halbhöhenbreiten von bis zu 31 nm. Zusätzlich wurden drei analoge Vertreter einer NBN-Phenalen Spezies dargestellt und charakterisiert. Die entgegengesetzte Dotierung äußert sich in einem grundlegend verschiedenem Redoxverhalten. Abschließend wurde die Reduktion des BNB-Phenalens 22 untersucht. Dabei gelang es das Radikal K[32] zu charakterisieren und seine Abbaureaktion in THF aufzuklären.
Incorporation of Nanoparticles Based on Zingiber Officinale Essential Oil into Alginate Films for Sustained Release
Authors:   School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang, Malaysia, Rosli Nur Ayshah , A. Islan German ,   Centro de Investigación y Desarrollo en Fermentaciones Industriales (CINDEFI), Laboratorio de Nanobiomateriales, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP) – CONICET (CCT La Plata), Calle 47 y 115, (B1900AJI), La Plata, Buenos Aires, Argentina, Hasham Rosnani ,   Department of Bioprocess and Polymer Engineering, School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia, R. Castro Guillermo ,   Nanomedicine Research Unit (Nanomed), Federal University of ABC (UFABC), Santo André, Sau Paulo, Brazil, Abdul Aziz Azila ,   Department of Chemical and Environmental Engineering, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
Published: September 2022

This research focused on the formulation of Ca2+ cross-linked alginate (Alg) gels containing Zingiber officinale oil extract (ZOE) loaded into a nanostructured lipid carrier (NLC). The NLC is intended to protect the Zingiber officinale oil against physical and chemical degradation during topical administration to sustain the drug release and reduce drug leakage during storage. The NLC was prepared using hot homogenisation and ultrasonication of glyceryl monostearate. Virgin coconut oil was used as the liquid lipid. The NLC-ZOE had a mean size diameter of 100 nm and a zeta potential value of −40 mV. The ZOE released from NLC followed the Korsmeyer- Peppas model case I (Fickian diffusion). The NLC-ZOE formulation was then incorporated into Alg. The gels were prepared via ionotropic gelation in the presence of calcium. Scanning electron microscopy (SEM) images of Alg films revealed successful intercalation of NLC within the Alg matrix. The in vitro ZOE release from NLC-ZOEAlg occurred in a sustained manner from the cross-linked Alg hydrogels compared to the free NLC. The profiles of NLC-ZOE released from the Alg films depended on the nanoparticles amount. The results demonstrated the importance of designing a local delivery system to entrap and control the release of the bioactive components of ZOE from within the Alg matrix. Ca2+ cross-linked Alg gels containing ZOE loaded into NLC was found to be suitable for topical delivery applications, as shown by the sustained release of ZOE from calcium cross-linked Alg films containing NLC that was demonstrated in this study.
To what extent are item discrimination values realistic? A new index for two-dimensional structures
Authors: KILIÇ Abdullah Faruk , UYSAL İbrahim
Published: September 2022

Most researchers investigate the corrected item-total correlation of items when analyzing item discrimination in multi-dimensional structures under the Classical Test Theory, which might lead to underestimating item discrimination, thereby removing items from the test. Researchers might investigate the corrected item-total correlation with the factors to which that item belongs; however, getting a general overview of the entire test is impossible. Based on this problem, this study aims to recommend a new index to investigate item discrimination in two-dimensional structures through a Monte Carlo simulation. The new item discrimination index is evaluated by identifying sample size, item discrimination value, inter-factor correlation, and the number of categories. Based upon the results of the study it can be claimed that the proposed item discrimination index proves acceptable performance for two-dimensional structures. Accordingly, using this new item discrimination index could be recommended to researchers when investigating item discrimination in two-dimensional structures.
Effect of network strategic capabilities on digital transformation in Jordanian universities
Authors: AL Afaishat Tayseer , Khraim Hamza , Al-Maadhedee Maan
Published: September 2022

The study aims to explore the effect of network strategic capabilities (NSCs) with its dimension of artificial intelligence (AI) and blockchain on digital transformation (DT) in Jordanian universities. The paper used the analytical-descriptive approach to analyze and interpret the results. The study population includes Jordanian universities, and the sample consists of top management. Out of 400, 304 questionnaires were completed and returned. The results show that AI (β = 1.219, t = 1.175, p < 0.00) and blockchain (β = –0.773, t = 0.437, p < 0.00) have a significant effect on DT. The first sub-hypothesis results concerning leadership revealed that AI (β = 0.525, t = 0.360, p < 0.03) and blockchain (β = –0.538, t = 0.186, p < 0.04) have a significant effect on leadership. The second sub-hypothesis result concerning strategic planning revealed that AI (β = 4.031, t = 3.050, p < 0.002) and blockchain (β = –5.150, t = 2.334, p < 0.020) have a significant effect on strategic planning. While for third sub-hypothesis concerning infrastructure, the results of AI were β = 0.818, t = 1.011, p < 0.032 and for blockchain β = 0.159, t = 0.121, p < 0.904. This result shows that AI has a significant effect on infrastructure, while blockchain does not have any effect. Therefore, NSCs must be integrated into the business process to enhance and boost DT efficiently and effectively.
A Proposal for Re-structuring of Nurses and Midwives’ Promotions and Ranks toward an Advance Professional Practice in Ghana
Authors: Wombeogo Michael , Daborikuu Bridget , Maambo Cynthia
Published: September 2022

Staff promotion is the advancement of an employees’ rank or position in an organizational hierarchical system. A Study explains that promotion when and wherever it happens, comes with two impressions: the monetary aspect and the change of position from lower to higher in the organizational hierarchy. This study aims at presenting a proposal for re-structuring of Nurses and Midwives’ promotions and ranks toward an advance professional practice in Ghana. A descriptive, phenomenological qualitative study was used. The study established that ranking and promotions in nursing and midwifery should be based on qualification and experience and not just number of years served in the health sector. The respondents largely added that for nurses and midwives to be academically active with apt skills in their respective fields, promotions should also be based on some number of scholarly papers published in reputed journals. Accordingly, the Nursing and Midwifery Council must ensure that nurses and midwives adhere to these protocols towards ranking and remuneration. In conclusion, ranking is beneficial for the advancement of the nursing and midwifery professions in Ghana. Keywords: Ghana, Nurses and midwives, Promotions, Professional practice, Ranks, Re-structuring.
Assessing the Importance and Benefits of Continuing Professional Development to Technical University Lecturers in Ghana
Authors: Owusu-Boateng William
Published: September 2022

The main objective of the study was to find out the importance and benefits lecturers at technical university lecturers in Ghana derive from continuing professional development. The study was qualitative in nature, and a sample size of forty-eighty was chosen. The sample size was chosen from two technical universities. The sample comprised six deans of faculties, six heads of departments, and thirty-six lecturers. Two interview schedules were used for the data collection. One of the interview schedules was used to interview the deans and heads of departments, and the other was used to interview the lecturers. The study revealed that CPD plays an important role for lecturers as it helps them stay abreast with the happenings in their area of specialties. It, moreover, helps them to stay relevant to their students so that the students explore their latent qualities. CPD helps lecturers to gain self-confidence and self-actualization. It equips lecturers to qualify to apply for promotions and appointments. The more the lecturers embark on CPD, they learn the relevant skills to conduct research and come out with innovative results which are published in recognized journals. The benefit the lecturers enjoy is that it helps them to conduct and publish quality results which puts them in a better position to qualify and apply for promotions and appointments. The students benefit from CPD as it helps lecturers to acquire innovative and better teaching methods which make lectures interesting and understanding. It is recommended that all lecturers should make it a policy to attend at least one CPD program a year. Keywords: Professional development, self-actualization, promotion, appointments, and publications.
Evaluating Strategic Planning as Intervention Tool for Improving Healthcare Delivery in Private Hospitals in Ojodu, Lagos
Authors: Abiola Olaitan Olusola
Published: September 2022

The Nigerian healthcare sector is currently faced with various incapacitating problems making universal health coverage difficult and the healthcare workforce being poorly managed. In a bid to manage these problems effectively, it has become pertinent, more than ever, for healthcare managers to resort to use of strategic management tools to improve the overall health status of the teeming population of Nigeria as these tools have been proven effective in other non-health industries. This study, therefore, examines the influence of different aspects of strategic planning like facility planning, professional improvement planning, manpower planning, health services planning, and customer service planning on different components of healthcare delivery like patient safety, waiting time, medical staff retention, the effectiveness of health services, people-centeredness, and equitable service delivery. Cross-sectional and random sampling techniques were adopted to administer 123 copies of the questionnaire to a population of 178 managers of private hospitals in Ojodu, out of which 111 copies were validly filled and returned by the respondents representing a 90.24% response rate. Simple regression analysis was adopted to analyze the six hypotheses of this study, and the results showed that they were all statistically significant at a 5% significance level. Based on the findings of this study, it is concluded that strategic planning is a valuable tool that can be used to improve healthcare delivery in private hospitals. The study, therefore, recommends that managers of private hospitals should be trained in the use of strategic planning tools in order to fully exploit the benefits inherent in the strategic planning processes. Keywords: Healthcare delivery, Hospitals, Intervention, Strategic planning.
Barriers to SME Computerization in Developing Countries: Evidence from SMEs in North Kivu, Democratic Republic of Congo
Authors: Kalumendo Rodrigue
Published: September 2022

SMEs are widely recognized as the development enablers in developing countries. They contribute to job creation and, in so doing, to poverty reduction. To remain competitive, SMEs use several tools, including computerized information systems. However, given their characteristics, several constraints hinder their computerization; these constraints are even more accentuated in developing countries. This study attempted to identify the barriers to computerization as outlined in the literature and to ascertain them in the DRC context. In order to achieve this, we examined the relevant literature and carried out a survey of 53 respondents, principally local ICT stakeholders. Using descriptive statistics, we established that Congolese SMEs face the same computerization challenges identified in the literature. These constraints include the local SME characteristics - poor financial resources, low internal and external expertise, and low management involvement -, high infrastructure costs - expensive software and hardware - and the availability of the technological infrastructure - poor internet access -. The Congolese digital ecosystem stakeholders can, each at their own level, use these results to assist the digitalization of Congolese SMEs and thus make them more agile in the achievement of their goals. Keywords: ICT, Barriers, Computerization, DRC, SME.
New Biomarkers and Immunotherapy Decision
Authors: Yigit Abdurrahman , Kuscu Berkay , Kirik Ali , Ozcaglayan Ruhsen , Afsar Cigdem Usul
Published: September 2022

As immune checkpoint blockade and other immune-based therapy
approaches lead to broad treatment advances among patients with advanced cancer, an
important consideration is how to best select patients whose tumors will respond to
these therapies. As a consequence predictive and prognostic markers are needed. There
are genomic features, such as tumour mutation burden (TMB), microsatellite instability
(MSI), and immune phenotype features, such as programmed death-ligand 1 (PD-L1),
CTLA-4 and tumour infiltrating lymphocytes (TILs), to predict response to
immunotherapies (ITs). Several studies show the correlation between TMB and
predicted neoantigen load across multiple cancer types. Response to immune
checkpoint inhibitors is higher in tumours with high TMB. The candidate biomarker
that has been studied mostly other than TMB is PD-L1 expression in trials utilizing
programmed cell death-1 (PD-1) blockade. PD-L1 and PD-1 expression are dynamic
markers that change in relation to local cytokines and other factors, and the thresholds
that separate “positive” and “negative” PD-L1 expressions remain under debate. PD-L1
expression is now a routine diagnostic marker for patients with newly diagnosed
NSCLC. The potential applicability of PD-L1 in other disease settings is still uncertain.
Microsatellite instability is characterised by high rates of alterations to repetitive DNA
sequences caused by impaired mismatch repair (MMR); MSI was the biomarker was
approved according to tumor's initial location. Combining TMB with specific genomic
alterations is crucial. Moreover, new biomarkers are being investigated.
Novel Applications of Biomarkers in Chronic Obstructive Pulmonary Disease
Authors: Uysal Pelin
Published: September 2022

Chronic obstructive pulmonary disease (COPD) is an important health problem and an increasing cause of morbidity and mortality worldwide. Currently, COPD is considered a multisystem disease. Although it primarily affects the lungs, structural and functional changes occur in other organs due to systemic inflammation. It is stated that in patients with COPD, airway and systemic inflammatory markers are increased and that these markers are high are associated with a faster decline in lung functions. In recent years, numerous articles have been published on the discovery and evaluation of biomarkers in COPD. Many markers have also been studied to accurately assess COPD exacerbations and provide effective treatment. However, based on the evidence from published studies, a single molecule has not been adequately validated for broad clinical use.
Croquis paradigmático de la Teoría de la Modernización. Una perspectiva desde la economía del desarrollo
Authors:   UniRemington, More Olivares Elias
Published: September 2022

este artículo pretende analizar el concepto de modernización entendido como el cierre de la brecha entre tradición y modernidad, buscando imitar a los países industrializados. Los autores más destacados que abordan esta temática son Walt Rostow (etapas del crecimiento), Talcott Parsons (acción social), Arthur Lewis (dualismo) y Simon Kuznets (estructura del capitalismo). Basados en estas fuentes, se evaluarán las etapas del crecimiento que son impactadas por la inversión-ahorro, el Tricle-down y la Ü invertida de Kuznets. Por limitaciones de espacio, otros pioneros se proponen al final para continuar con una investigación formativa.
Pathogen-oriented approaches for neonatal calf diarrhea
Authors: van Mol W. , Clinquart J. , Pas M.L. , Bokma J. , Pardon B.
Published: September 2022

Neonatal calf diarrhea (NCD) is the leading health concern in calves during the first weeks of their lives. In this narrative review, the potential for pathogen-oriented approaches for NCD is discussed. The literature on NCD clearly shows substantial differences in spread and characteristics between the major NCD pathogens, making pathogen-oriented approaches possible, justifying the use of etiological diagnostics. For enterotoxic Escherichia coli, colostrum delivery and dam vaccination, biosecurity around calving and antimicrobial therapy are key. Both for bovine coronavirus (BCV) and bovine rotavirus (BRV), biosecurity and disinfection, dam vaccination in combination with adequate and prolonged colostrum delivery are the essentials. However, a different focus concerning biosecurity is necessary given the airborne spread of BCV and higher environmental persistence of BRV. For an effective Cryptosporidium spp. control, the use of disinfectants that kill oocysts is crucial. Evidence supporting the prophylactic use of halofuginone lactate to reduce shedding and diarrhea, is available, but in terms of biosecurity, attention should be placed on the proper use of this product. In case of a Salmonella enterica outbreak, antimicrobial use remains important, and biosecurity wise, attention should be paid to shedding of periparturient cows in the calving pen and administration of infected colostrum. Both for S. enterica and cryptosporidiosis, farm staff should be informed on how to protect themselves against these zoonotic infections. Nutritional factors play an additional role within NCD. Improper nutrition management can induce diarrhea or can further enhance infectious NCD through osmosis or dysbiosis. In conclusion, the suggested pathogen-oriented approaches can aid to economize labor and financial investments, limit the environmental impact of NCD control and prevention and valorize tailor-made farm advisory work.
How to Engage in Practices of Critique? From a Universal Conception of the Good Life to the Contestation of Universals
Authors: Hagen Annemarije
Published: September 2022

Critical social theories examine social arrangements from the point of view of the obstacles that these structures pose to human flourishing, with the purpose of bringing about social change for the better. In this article, I contest the idea that these changes have to be guided by an idea of the good society. I argue that actual struggles are not guided by abstract ethical representations of the good life, but more negatively, by contestation of the limits of articulated universals by the ones who are excluded and marginalised.
Perspectives that Matter
Authors: Fumagalli Corrado
Published: September 2022

Review of: Ryan Muldoon (2016) Social Contract Theory for a Diverse World: Beyond Tolerance. New York: Routledge. 142 pp.
Bezint eer gij bezet! (of niet)
Authors: Halffman Willem
Published: September 2022

Bespreking van: Joost De Bloois (2016) In naam van het Maagdenhuis. Amsterdam: Leesmagazijn, 120 pp. & Casper Thomas (2015) Competente rebellen: Hoe de universiteit in opstand kwam tegen het marktdenken. Amsterdam: Amsterdam University Press, 192 pp.
Experimental Procedures for New Ontologies
Authors: Kayzel Tom , Schilpzand Sigmund Bruno
Published: September 2022

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The Aesthetics of Ideology
Authors: Sinnerbrink Robert
Published: September 2022

Review of: Aesthetic Marx (2011) edited by Samir Gandesha & Johan F. Hartle. London and New York: Bloomsbury Academic, 283 pp.
Preparation of Cobalt-Silica Dioxide (CoxSiO2) Catalyst through Impregnation Method
Authors: Mawaddah Isthifaul , Utomo M. Pranjoto
Published: September 2022

The CoxSiO2 catalyst have been synthesized by reacting amount of cobalt nitrate and silica dioxide through impregnation method with vatiation on x= 0, 0.025, 0.05, and 0.1. The resulted materials were characterized using UV-Vis DRS, FT-IR, XRD, and SEM-EDX instruments. The XRD results showed that Co-SiO2 catalyst have peaks at 2θ of 21.5º (for x = 0.025), 14.52º (for x = 0.05), and 21.58º (for x = 0.1). The CoxSiO2 catalysts were amorphous with average size of 4-11 nm and the band gap were at around of 1-3 eV.
Methyl Orange Dye Removal through Adsorption using TiO2 modified Montmorillonite Granule
Authors: Yuliana Dewi , Priyambodo Erfan
Published: September 2022

This research was conducted to determine the characteristics of TiO2 modified montmorillonite granule and to determine the effectiveness of its filtration against methyl orange dye. Montmorillonite granule particles were made through a pressing process and continued with sintering at 900oC. The granules obtained were coated with TiO2 photocatalyst by the deep coating method. The montmorillonite granules were characterized using SEM-EDX and the methyl orange dye adsorption process was carried out using the column method. The SEM analysis showed that the granules is porous materials and the EDX confirm the increasing of TiO2 content in montmorillonite before and after being coated with TiO2 from 0.50% to 22.66%. The best adsorption effectiveness of methyl orange was 96.6% at the flow rate of 0.0083 L/hour, which occurred in the use of TiO2 modified montmorillonite granule.