bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of cellular substrates of human RNA decapping enzyme Dcp2 using a stapled bicyclic peptide inhibitor
Authors: Luo Yang , Na Zhenkun , Slavoff Sarah A. , Simon Matthew D. , Schofield Jeremy A. , Hann Tanja
Published: November 2020

Dcp2 is an important enzyme that controls the stability of a subset of human cellular RNAs encoding functions such as transcription and immune responses. While >1800 Dcp2 substrates have been identified in human cells, compensatory gene expression changes secondary to genetic ablation of the DCP2 gene have complicated a complete mapping of its regulome. Cellpermeable, selective chemical ligands of Dcp2 could facilitate development of improved tools for elucidation of its function and cellular specificity. Here, we report the selection of a bicyclic peptide ligand of human Dcp2 from chemically cyclized phageencoded libraries, and evaluation of its affinity and selectivity for Dcp2 in vitro and in cells. Quantitative reverse transcription PCR (qRT-PCR) combined with a splinted ligation assay revealed that this stapled bicyclic peptide inhibits Dcp2 decapping activity toward specific RNA substrates inside human cells. We further demonstrate that CP21 increases formation of P-bodies, cellular liquid condensates enriched in intermediates of cellular RNA decay, in the same manner as deletion or mutation of Dcp2. Collectively, these results demonstrate development of a selective ligand of Dcp2 that modulates some of its functions inside cells. In the future, this molecule – and, more broadly, stapled peptide selection – may find utility in reverse chemical genetics to dissect the specificities of coexistent cellular RNA decay pathways.
Click Activated Protodrugs Against Cancer Increase the Therapeutic Potential of Chemotherapy through Local Capture and Activation
Authors: Wu Kui , Yee Nathan , Srinivasan Sangeetha , Mahmoodi Amir , Zakharian Michael , Mejia Oneto Jose M. , Royzen Maksim
Published: November 2020

A desired goal of targeted cancer treatments is to achieve high tumor specificity with minimal side effects. Despite recent advances, this remains difficult to achieve in practice as most approaches rely on biomarkers or physiological differences between malignant and healthy tissue, and thus benefit only a subset of patients in need of treatment. To address this unmet need, we introduced a Click Activated Protodrugs Against Cancer (CAPAC) platform that enables targeted activation of drugs at a specific site in the body, i.e., a tumor. In contrast to antibodies (mAbs, ADCs) and other targeted approaches, the mechanism of action is based on in vivo click chemistry, and is thus independent of tumor biomarker expression or factors such as enzymatic activity, pH, or oxygen levels. The platform consists of a tetrazine-modified sodium hyaluronate-based biopolymer injected at a tumor site, followed by one or more doses of a trans-cyclooctene (TCO)- modified cytotoxic protodrug with attenuated activity administered systemically. The protodrug is captured locally by the biopolymer through an inverse electron-demand Diels-Alder reaction between tetrazine and TCO, followed by conversion to the active drug directly at the tumor site, thereby overcoming the systemic limitations of conventional chemotherapy or the need for specific biomarkers of traditional targeted therapy. Here, TCO-modified protodrugs of four prominent cytotoxics (doxorubicin, paclitaxel, etoposide and gemcitabine) are used, highlighting the modularity of the CAPAC platform. In vitro evaluation of cytotoxicity, solubility, stability and activation rendered the protodrug of doxorubicin, SQP33, as the most promising candidate for in vivo studies. Studies in rodents show that a single injection of the tetrazine-modified biopolymer, SQL70, efficiently captures SQP33 protodrug doses given at 10.8-times the maximum tolerated dose of conventional doxorubicin with greatly reduced systemic toxicity.
Cobalt-Iron Alloy Nanoparticles Impregnated Partially Graphitized Carbon Adsorbent from Metallized Bagasse for Organic Pollutants Removal
Authors: Rashmi M. Sai , S. Akhila , Duas Velvita , Singh Ashish , Samal Akshaya , Devan Rupesh , Saxena Manav
Published: November 2020

Here, we report a highly efficient adsorbent obtained from the carbonization of metallized bagasse. The material is characterized using FESEM, HRTEM, PXRD, zeta-potential and VSM techniques. The material shows an impressive adsorbent property for anionic dyes, pharmaceutical (paracetamol) along with commercially used ‘hair dye’. Further, pH triggered adsorption of Methylene orange (MO), Congo red (CR), Amido black (AB), and paracetamol were studied and results show an impressive adsorption capacity of 1102.9, 1253.9, 877.2, 227.8 mg/g respectively. It is seen that under experimental conditions, adsorbent shows ultrafast adsorption kinetics where ~96% AB dye gets adsorbed in just 5 min, 93% of CR adsorption in 5 min and ~89% of MO adsorption in 5 min. Also, we could observe fast adsorption rate for commercially used ‘hair dye’ and paracetamol drug. Interestingly, in just 5 min, 95% of hair dye adsorption is seen and ~84% drug removal with maximum adsorption capacity of , recyclability of the adsorbent demonstrates the practical benefits of the material for waste water remediation.
Selection of uric acid oxidizing-Lactobacillus plantarum isolates based on their genetic determinant and uricase kinetics
Authors: Desi Meriyanti  , I Made Artika  , Novik Nurhidayat
Published: November 2020

Hyperuricemia is a condition characterized by abnormally elevated levels of uric acid in the blood. It has been a leading morbidity disease. Microbial uricase can be used to oxidize uric acid into allantoin and hydrogen peroxide in the presence of oxygen and therefore has the potential to play an essential role in reducing uric acid in the people suffering from degenerative disease of hyperuricemia. The present study aims to select uric acid oxidizing-Lactobacillus plantarum isolates based on their genetic determinant and uricase kinetics. A collection of Lactobacillus plantarum isolates were grown on a selective differential medium followed by measuring their uricase activity spectrophotometrically. Specific primers for detection of uricase gene were designed. The uricase coding gene (uox) was then detected in all of the selected isolates by using a qPCR method employing the designed specific primers. The uricase kinetics was determined by the Lineweaver-Burk method. Results showed that all isolates had uricase activity and 4 potential isolates were selected based on their superior uricase activity. The uox gene was detected in all of the selected isolates. The kinetics analysis, however, revealed that only the L. plantarum K-Mar-A2 show strongest substrate affinity and was considered a potential candidate to be developed as a source of therapeutic agent for hyperuricemia.
THE TRAINING OF GEOGRAPHERS IN THE MODERN DEVELOPMENT TENDENCIES CONDITIONS OF AZERBAIJAN REPUBLIC
Authors: Сулейманова Нармина Саттар кызы
Published: November 2020

Цель исследования - показать первые территориальные открытия в географии Азербайджана и процесс формирования национальной школы географии. Хронологический подход раскрывает последовательный процесс географических открытий и исследований Азербайджана как территории древнего освоения с историческими городами и местностями.

The purpose of the study is to show the first territorial discoveries in the geography of Azerbaijan and the process of forming a national school of geography. The chronological approach reveals a consistent process of geographical discoveries and explorations of Azerbaijan as a territory of ancient development with historical cities and localities.
GLOBAL METAMORPHOSIS OF DEVELOPMENT OR NEW FEATURES OF NEOMALTU SIANISM?
Authors: Исмаилов Чингиз Ниязи оглы
Published: November 2020

В статье проанализированы глобальные процессы обострения социальноэкономического положения и показаны факторы, создавшие такие негативные изменения. Наряду с этим, раскрыты отличительные черты новой кризисной ситуации, при которой проявились реальные и содержательные особенности, широко пропагандируемых, либеральной демократии и западных ценностей. В качестве дискуссионной проблемы поставлен вопрос о возможности возрождения идей неомальтузианства. В заключении статьи особо подчеркнута необходимость переустройства всей мирохозяйственной системы отношений, которая показала всю глубину внутренних противоречий.

The article analyzes the global processes of aggravation of the socio-economic situation and shows the factors that create such negative changes. Along with this, the distinctive features of the new crisis situation have been revealed, in which real and substantial features, widely propagated, liberal democracy and Western values have appeared. The issue of the possibility of reviving the ideas of neo-Malthusianism is raised as a discussion problem. The article concludes by emphasizing the need to reorganize the entire world economic system of relations, which has shown the full depth of internal contradictions.
RESETTLEMENT TRANSFORMATION AND LIVING CONDITIONS OF LOCAL POPULATION IN THE COASTAL ZONE OF THE MOSCOW SEA
Authors: Сергеева Маргарина Сергеевна
Published: November 2020

Показаны особенности прибрежного расселения в зоне крупного водохранилища (на примере Конаковского района Тверской области), представлена генетическая структура прибрежных сельских населённых пунктов, выявлены формы трансформации расселения в связи с созданием водохранилища и активным рекреационным освоением для организации отдыха столичных жителей. Представлены результаты онлайн-опроса местных жителей о проблемах, вызванных соседством с зонами и объектами элитного отдыха.

The features of coastal resettlement in the zone of a large reservoir (on the example of Konakovsky district of Tver region) are shown, the genetic structure of coastal rural settlements is presented, forms of settlement transformation are identified in connection with the creation of a reservoir and active recreational development for organizing recreation for residents of the capital. The results of an online survey of local residents about the problems caused of proximity to areas and objects of elite recreation are presented.
MODERN THEORETICAL APPROACHES TO UNDERSTANDING AND TOPICAL ISSUES OF RESEARCH ON THE TERRITORIAL ORGANIZATION OF RECREATION AND TOURISM
Authors: Амелькина Дарья Владимировна
Published: November 2020

В статье систематизированы подходы отечественных ученых к исследованиям территориальной организации рекреации и туризма, выполненным на основе геосистемного анализа и классических теоретических моделей; подчеркивается преемственность научных идей отечественной школы социально-экономической и рекреационной географии в области изучения территориальных систем, связь с зарубежными экономгеографическими теориями и концепциями. Делается вывод о том, что актуальность исследований территориальной организации туризма в настоящее время формируется вызовами постиндустриальной эпохи и неразрывно связана с гуманитарными аспектами функционирования рекреационных систем, в т.ч. территориальными и ресурсными противоречиями, порождаемыми развитием рекреации и туризма.

The article systematized approaches of domestic scientists to study the territorial organization of recreation and tourism, based on geosystem analysis and classical theoretical models; emphasizes the continuity of scientific ideas of the national school of socio-economic and recreational geography in the study of territorial systems, communication with foreign economy-geographical theories and concepts. It is concluded that the relevance of research on the territorial organization of tourism is currently formed by the challenges of the post-industrial era and is inextricably linked with the humanitarian aspects of the functioning of recreational systems, including territorial and resource contradictions generated by the development of recreation and tourism.
SPATIAL MARGINALIZATION: APPROACHES AND LEVELS OF RESEARCH
Authors: Преображенский Юрий Владимирович
Published: November 2020

В статье уточняется понятие маргинальности как пространственной категории. Рассматривается соотношение понятий периферизации и маргинализации. Приводятся и описывается ряд подходов к выделению маргинальных территорий. Выявляются различия между таксонами исследования процессов экономической и культурной маргинализации. Рассматривается процесс городской маргинализации.

The article clarifies the concept of marginality as a spatial category. The relationship between the concepts of peripherization and marginalization is considered. A number of approaches to the allocation of marginal territories are presented and described. Identifies the differences between the taxa of the study of the processes of economic and cultural marginalization. The process of urban marginalization is considered.
MOBILE GIS-TECHNOLOGY FOR GEOGRAPHIC AND BYOLOGICAL EDUCATION
Authors: Мидоренко Дмитрий Адольфович , Жеренков Александр Григорьевич
Published: November 2020

В статье рассмотрен опыт разработки и внедрения в образовательный процесс ВУЗа мобильных ГИС-технологий. Описаны особенности использования мобильных решений для организации и проведения практических и лабораторных занятий, а также полевых учебных практик бакалавров естественно-научных направлений Тверского государственного университета.

The article discusses the experience of developing and implementing mobile GIS technologies in the educational process of a university. The specifics of using mobile solutions for organizing and conducting practical and laboratory studies, as well as for field training courses for undergraduate natural sciences at Tver State University.
CASE-STUDY FOR GEOGRAPHY RESEARCHERS: BIG DAMASCUS
Authors: Альсулейман Мохаммад Исса
Published: November 2020

Предложена авторская разработка кейса для изучения городских агломераций в курсе «Пространственное планирование» - для магистров-географов. Городские агломерации как основные формы современного городского расселения - это один из типов районов территориального планирования (районной планировки) во всех странах мира. В России для городских агломерации разрабатываются Схемы территориального планирования. В географии - это популярная тема исследований. Опыт профессиональной оценки трансформации планировочной структуры городских агломераций - важная компетенция географов-исследователей. Кейс разработан для Большого Дамаска (Сирия).

The author developed a case study for the study of urban agglomerations in the course «Spatial Planning» for geographers. City agglomerations as the main forms of modern urban settlement - this is one of the types of areas of territorial planning (district planning) in all countries of the world. In Russia, for urban agglomeration, Territorial planning schemes are being developed. In geography, this is a popular research topic. The experience of professional assessment of the transformation of the planning structure of urban agglomerations is an important competence of geography researchers. The case was developed for Greater Damascus (Syria).
Chiropterans of the Tver region (Russia) at the wintering grounds: underground cavities of the Staritsa district
Authors: Емельянова Алла Александровна , Христенко Екатерина Андреевна , Волкова Алёна Сергеевна , Кулагин Андрей Михайлович
Published: November 2020

Дан исторический обзор изучения оседлых видов рукокрылых на территории Тверской области. Проведен анализ хироптерофауны на зимовках в подземельях Старицкого района. На основании оценки встречаемости, относительной численности и относительного обилия установлены статусы видов летучих мышей, обитающих на территории Тверской области в период гибернации.

A historical review of the study of the local species of bats in the Tver region is given. The analysis of the chiropterans at wintering grounds in the underground cavities of the Staritsa district is presented. The statuses of bats inhabiting the Tver Region during hibernation are established. The statuses are based on the occurrence, relative number, and relative abundance of each species of bats.
Number dynamics of the moose, wolf, and bear in the Kemerovo region from the second half of the 20th century to the beginning of the 21st century
Authors: Скалон Николай Васильевич , Степанов Павел Георгиевич , Просеков Александр Юрьевич
Published: November 2020

Представлен анализ динамики численности лося, медведя и волка на территории Кемеровской области (Кузбасса) за последние 70 лет. Максимальных значений численность лося достигала в 1976-1979 гг. (7000 особей), минимальных - в 1994 г. (1850 особей). В настоящее время количество лосей на территории Кемеровской области превысило 5,0 тыс. особей с тенденцией к повышению. Количество медведей в Кемеровской области на протяжении всего исследуемого периода непрерывно возрастает с 300-400 особей в начале 1960-х гг. до 3,0-3,1 тыс. в 2017-2019 гг. Волк на территории Кузбасса находится под жёстким антропогенным прессом. Максимальное количество волков в 400-450 голов отмечалось в 1994-1996 гг., в настоящее время этот хищник практически истреблён, периодически отмечаются заходы 2-7 зверей из сопредельных регионов в зимнее время. Проанализированы основные факторы, влияющие на численность лося: охота, хищничество волка и медведя, качество работы органов госохотнадзора. Показано, что в Кемеровской области количество лося, волка и медведя зависит, в первую очередь, от охотхозяйственной деятельности. Достоверная отрицательная корреляция лося с численностью медведя и волка выявляется только на отдельных временных отрезках, когда она налагается на отрицательное антропогенное воздействие.

The analysis of the dynamics of the number of moose, bear, and wolf in the territory of the Kemerovo region (Kuzbass) over the past 70 years is presented. The maximum number of moose reached in 1976-1979 (7000 individuals), the minimum - in 1994 (1850 individuals). Currently, the number of moose in the Kemerovo Region has exceeded 5.0 thousand individuals with an upward trend. The number of bears in the Kemerovo region throughout the study period is continuously increasing from 300-400 individuals in the early 1960s up to 3.0-3.1 thousand in 2017-2019. The wolf on the territory of Kuzbass is under severe anthropogenic pressure. The maximum number of wolves of 400-450 animals was observed in 1994-1996. At present, this predator is almost exterminated. Only 2-7 animals from neighboring regions are periodically noticed in winter. The main factors affecting the moose abundance are analyzed: hunting, predation of a wolf and a bear, and the quality of work of State Hunting Surveillance bodies. The number of moose, wolf and bear in Kemerovo Region depends mainly on hunting activities. A reliable negative correlation of the moose with the number of bears and wolves is detected only in some intervals when it is imposed on a negative anthropogenic impact.
Temperature stratification and photosynthetically active radiation distribution in the Zostera noltii Hornemann canopy under shallow water conditions at different solar elevation angles (the Black sea)
Authors: Празукин Александр Васильевич , Фирсов Юрий Константинович , Латушкин Александр Александрович , Чепыженко Анна Алексеевна
Published: November 2020

Морские травы экологически важны, но чрезвычайно уязвимы перед антропогенными изменениями в прибрежных зонах, которые влияют на доступность света в этих экосистемах. При разной высоте Солнца над горизонтом в зондирующем режиме проводилось одновременное измерение значений температуры воды и интенсивности фотосинтетически активной радиации (IPAR) по профилю полога Zostera noltii Hornemann (высота полога 32 см.) в мелководной части Казачьей бухты (г. Севастополь, Черное море, 44°57′26″ с.ш., 33°40′33″ в.д.). Для полога Z. noltii характерен одномодальный тип вертикального распределения биомассы с максимумом (65,7 г (сухой массы) / м2) в его нижней части. Рассматривается изменение температурной стратификации и распределения IPAR по профилю растительного полога Z. noltii в течение светового дня.

Seagrass is environmentally significant but extremely vulnerable in coastal areas to anthropogenic changes, which affect light availability. Simultaneous measurements of water temperature and photosynthetically active radiation (PAR) intensity in the sounding mode were taken at different solar elevation angles for the Zostera noltii Hornemann canopy (canopy height 32 cm) in shallow waters of the Cossack Bay (Sevastopol, the Black Sea, 44°57′26″ с.ш., 33°40′33″ в.д.). Z. noltii canopy is characterized by a unimodal type of biomass vertical distribution with its maximum (65,7 g (dry matter)/m2) in the lower part. Temperature stratification and IPAR distribution changes within the Z. noltii vegetation canopy profile during daylight hours are considered.
Total nitrogen content in vegetative organs of lawn plants in urban environment
Authors: Половникова Марина Григорьевна , Воскресенская Ольга Леонидовна
Published: November 2020

В условиях городской среды в вегетативных органах газонных растений (клевер луговой, мятлик луговой) определяли содержание общего азота. В работе использовались растения трех возрастных состояний: виргинильные (v), средневозрастные генеративные (g2) и субсенильные (ss). По мере усиления загрязнения среды и в ходе онтогенеза уменьшалось содержание общего азота в листьях и корнях газонных растений. При этом повышенное содержание общего азота в вегетативных органах было характерно для особей Trifolium pratense L. по сравнению с особями Poa pratensis L

Total nitrogen content was determined in the vegetative organs of lawn plants (Trifolium pratense L., Poa pratensis L.) in the urban environment. We used plants of three age ranges: virginile (v), middle-aged generative (g2), and subsenile (ss). As pollution increased as well as during ontogenesis, the total nitrogen content in the leaves and roots of lawn plants decreased. The increased content of total nitrogen in vegetative organs was typical for individuals Trifolium pratense L. compared with individuals Poa pratensis L.
Mobile gis-application for morphological soil description
Authors: Жеренков Александр Григорьевич , Мидоренко Дмитрий Адольфович
Published: November 2020

В статье рассмотрен опыт разработки мобильного приложения, работающего на стыке биологии и географии. Описаны возможности нового мобильного ГИС-приложения для полевого морфологического описания почвы как для научно-исследовательской работы, так и для полевых учебных практик студентов естественно-научных направлений Тверского государственного университета.

The article discusses the experience of using mobile applications that work at the intersection of biology and geography. The capabilities of the new mobile GIS application for the field morphological description of the soil both for research work and for field training practices of students of natural sciences in Tver State University are described.
In Memoriam – Dr. Leon M. Payawan Jr.
Authors: Usman Ken Aldren S. , Edañol Yasmin D.G. , Conato Marlon T.
Published: November 2020

On September 25, 2020, the Philippine chemistry society lost one of its most eminent members. Herein we reflect on the life and work of Dr. Leon M. Payawan Jr., referred to as Leon by his close friends and colleagues. We highlight some of his contributions that left a huge impact, not only to his students and cohorts, but also to the Philippine research community in general, both locally and internationally.
Incoherent superconductivity well above Tc in high-Tc cuprates - harmonizing the spectroscopic and thermodynamic data
Authors: Storey James
Published: November 2020

© 2017 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft. Cuprate superconductors have long been known to exhibit an energy gap that persists high above the superconducting transition temperature (Tc). Debate has continued now for decades as to whether it is a precursor superconducting gap or a pseudogap arising from some competing correlation. Failure to resolve this has arguably delayed explaining the origins of superconductivity in these highly complex materials. Here we effectively settle the question by calculating a variety of thermodynamic and spectroscopic properties, exploring the effect of a temperature-dependent pair-breaking term in the self-energy in the presence of pairing interactions that persist well above Tc.We start by fitting the detailed temperature-dependence of the electronic specific heat and immediately can explain its hitherto puzzling field dependence. Taking this same combination of pairing temperature and pairbreaking scattering we are then able to simultaneously describe in detail the unusual temperature and field dependence of the superfluid density, tunneling, Raman and optical spectra, which otherwise defy explanation in terms a superconducting gap that closes conventionally at Tc. These findings demonstrate that the gap above Tc in the overdoped regime likely originates from incoherent superconducting correlations, and is distinct from the competing-order pseudogap that appears at lower doping.
Food Problem in the Middle East in Light of Challenges of the Green Economy
Authors: Isaev V. A. , Filonik A. О.
Published: November 2020

The food problem in the Arab region is the constant irritating factor. It depends almost in a full way on the severe local climate and with characteristic the lack of fertile land. It is also integrated rigidly into the general framework of factors of paramount political importance to keeping social calm practically in every place in the Arab East. Presently, high hopes are put on implementation of the sustainable growth concept which found itself capable to take over some niches in the international field while nowadays is penetrating by some of its elements and in a step by step mode in the form of materialised green growth idea into various practices in some Arab countries, including the Arab oil-exporters where it comes in sight more distinctly in the form of relatively broad experiments.
Available Cosmos: Geoinformation Technologies for Schoolchildren
Authors: Sergeeva M. A. , Voronina M. V. , Raskladkina M. K.
Published: November 2020

The article presents methodical and technical developments on the use of geoinformation technologies in secondary schools and additional educational institutions. The problem in the reorganization of the training courses of the Earth sciences has long been ripe. Its origins lie in the rapid expansion of the field of application of geospatial data, in the transformation of this sphere from a highly specialized to mass and, as a consequence, the needs of the aerospace business in obtaining highly qualified, erudite professionals. The development of aerospace education entails the need to develop new types of educational courses beginning with a school bench that will raise the prestige of earth sciences, break away from boring textbooks and bring the educational program in line with the needs of the economy and with the interests and capabilities of modern students.
Coverage of Current Issues in Cultural and Artistic Life of Kyiv-Pechersk Lavra
Authors: Kryvolapov Mykhailo , Kryvolapov Bogdan
Published: November 2020

The article highlights the role of the Kyiv-Pechersk Larva in religious activity as well as its role in education of many arts and cultural workers generations. The current problems of Ukrainian culture, art and science are also covered in this article.
Borys Hrinchenko Literary Heritage in Works of Graphic Artists
Authors: Kuzmenko Halyna
Published: November 2020

The article, in the retrospect of time, covers the peculiarities of publishing development in Ukraine in late nineteenth — early twentieth century the time of Borys Hrinchenko literary activity. It refines the essence of the term “illustration” and determines the specific character of the book illustration design, highlights the role and characteristics of the artist concerning the art of creation and finishing of the book. The article also reveals a brief art analysis of artistic features of the specific illustrations created by the graphic artists for the works of Borys Grinchenko.
Assemblage as Art Technique in Contemporary Art
Authors: Zhyrov Vasyl
Published: November 2020

In this article the content of the notions of “collage” and “аssemblage” is covered. The characteristic to аssemblage as a style of painting is given . Stylization of an artistic image through аssemblage is analysed.
Space, Form, Function of Recent Georgian Ceramics in Artistic Search
Authors: Izoria Maiia
Published: November 2020

Ceramics due to its material, creation of form and ability to be transformed in space includes all the trends of recent art. Its exposition and monument types comparing to other fields synthesize and become efficient in social space. According to tendencies of recent art, the contribution of ceramics is determined by the essential skills which were established by the fields being secular and sacred. At coexistence of these functionally various fields the applied esthetics were made with material of ceramics and by carrier of crucial elements in minor plastic samples.
Formation of Female Deity Archetype in Arts and Crafts of Ukraine
Authors: Konovalova Olha
Published: November 2020

The article investigates the origins and analyses the semantics of the sacred female figure of a womangoddess in the context of arts and crafts of archaic cultures in Ukraine. The connection between the religious beliefs and images of stylized female figures on the pottery of the Cucuteni-Trypillian culture and in the toreutics of Scythia.
Synthesis of Traditions and Innovations in Modern Easter Egg Decorating in Ukraine
Authors: Zinevich Vita
Published: November 2020

The article explores the features of the art of Ukrainian Easter eggs decorating at present stage. It analyses the changes in traditional Easter eggs decorating and innovative techniques in egg decoration. It is noted that the continuity of traditions influence positively the ethnic identity, impove communication between generations, and encourage share in life experience.
Training of Artists or Artisans?
Authors: Franc Małgorzata
Published: November 2020

The article analyses the situation in Polish art education after 1990. It is indicated that higher art education in Poland can be obtained in eighteen universities and five affiliates in eleven Polish cities. The complex situation of higher art education is examined. The role of applied arts is noted.
Chartered Accountant, Asean Economic Community and Industry 4.0
Authors: Riadi Sugeng
Published: November 2020

Penelitian ini membahas hasil dari beberapa penelitian tentang Chartered Accountant, Masyarakat Ekonomi ASEAN (MEA), Industri 4.0, tantangan dan kesempatan. Penelitian ini menggunakan pendekatan studi pustaka yang membandingkan dan meringkas beberapa literatur. Akuntan Indonesia (Chartered Accountant) siap menghadapi pasar bebas MEA. Perubahan masa depan baik ilmu akuntansi maupun akuntan yaitu; data akuntansi cloud, akuntansi dipengaruhi oleh kekuatan big data, integrasi informasi keuangan tradisional ke dalam sistem modern, akuntansi akan menjadi efisien dan mobile dan peran akuntan berubah secara radikal dan cepat. Masyarakat Ekonomi ASEAN (MEA) dan era industri 4.0 dapat menjadi peluang sekaligus ancaman bagi Indonesia, sehingga Akuntan Indonesia harus bersiap menghadapinya.

 Kata Kunci: Chartered Accountant, Masyarakat Ekonomi ASEAN, Industri 4.0
Dampak Kualitas Laporan Keuangan Perusahaan Badan Usaha Milik Negara Terhadap Efisiensi Investasi
Authors: Hariyanto Novita Sherla , Suganda Tarsisius Renald , Lembut Putu Indrajaya
Published: November 2020

This study aims to investigate the effects of financial statements’ quality towards over/under investment, the internal controls’ implementation towards over/under investment, and moreover the internal control as a moderating variable to strengthen the financial statements’ quality to over/under investment on state-owned listed companies in Indonesia Stock Exchange and state-owned non-listed companies as well. The data analysis techniques namely logistic regression analysis is used to measure the research problems. There are 96 listed and non-listed state-owned companies (not including financial services and insurance) used as research sample during period from 2015 to 2018. The findings of this study reject first and third hypotheses stating that the financial statements’ quality does not affect over/under investment and moreover, internal control as a moderating variable could not strengthen the effect of financial statements’ quality towards over/under investment. However, on the other hand, the second hypothesis in this study is accepted proofing that the implementation of internal control has positive effect on over/under investment.

 Keywords:  Quality of Financial Statements, The Internal Control, Investment Efficiency, State Owned Enterprises
Pengaruh Karakteristik Direksi Terhadap Kinerja Perusahaan yang Terdaftar di Bursa Efek Indonesia
Authors: Aprilia Audrey Winona , Febriany Renita , Haryono Luciana , Marsetio Nany Chandra
Published: November 2020

Directors are human resources who play an important role in maintaining the long-term sustainability of the company's business. Thus, this study aims to determine board size, CEO tenure, and foreign director on company performance in the non-financial industry on the Indonesia Stock Exchange in 2013-2018 with multiple linear regression analysis using 1,764 sample data from 294 companies. Contributions in this study using resource dependency theory, stewardship theory and foreign directors variables as indicators of independence. The results of the study board size have a significant positive effect on company performance, with an optimal number of 4-9 people because it can provide diverse perspectives and ideas in decision making. CEO tenure  does not affect ROA and ROE because the president director tends to reject and avoid risks and company's performance is influenced by all directors, not just the president director. Foreign directors have a significant positive effect on ROA with an optimal percentage of 26-50% because they provide different perspectives on decision making, but does not affect ROE with 51-75% of the optimal amount because does not have large influence to influence decisions in improving company performance.

Keywords:  Director’s Characteristics, Firm Performance, Resource Dependency Theory, Stewardship Theory.
Pengaruh Pengungkapan Laporan Tahunan Periode 2014-2018 dan Ukuran Perusahaan Terhadap Harga Saham. (Studi Kasus Pada Perusahaan BUMN yang Sahamnya Terdaftar Dalam IDX BUMN20)
Authors: Wibisono Demetrius Kunto , Yolanda Esther
Published: November 2020

This study aims to find out how the influence of Disclosure of Financial Statements for the period 2014 - 2018 and Company Size on the Stock Price. This case study was conducted by taking a sample of companies list on IDX BUMN20. This study uses the hypothesis testing method using IBM SPSS Statistics Subscription version 23. Based on the results of the study found that an increase in average disclosure in all companies listed on the IDX, in other words, an increase in awareness of the management of companies listed on the IDX to report both financial and non-financial information to the public. In addition, companies listed on the IDX are increasingly obedient to the policies made by the regulator (OJK) related to the disclosure of financial statements. The Annual Disclosure Variable does not partially affect the company's stock price, this is due to differences in the research sector and research year. Partially, the variable size of the company has an influence on stock prices, this is because investors are interested in investing in companies that have large assets and have a large market capitalization because they are considered more profitable. Simultaneously, the Annual Report Disclosure variable and company size variables have a significant effect on stock prices.

 Keywords: Annual Report Disclosure, Company Size, and Stock Price.
RATIONALITY: A CENTRAL POINT BETWEEN TRADITIONAL FINANCE AND BEHAVIOURAL FINANCE
Authors: V.A. Subramaniam , T. Velnampy
Published: November 2020

Investment plays an important role not only in the life of an individual but also in the development of countries. People save money for the purpose of future consumption and invest the saved money with the objectives of protecting the real value of money and making more money. Bodie, Kane & Marcus (1998) defined the term investment as the current commitment of money and other resources with the expectation of obtaining future benefits. Investment decision making is an important aspect in the process of investment, which relates with the selection of one or more investment options for investing the money.
IMPACT OF CREDIT RISK AND CAPITAL ADEQUACY ON ISLAMIC AND CONVENTIONAL BANKING HEDGING
Authors: Siddiq Abbokar , Gamal Ebrahim Al
Published: November 2020

This study aims to examine the relationship between credit risk and capital adequacy with the banking hedging of Islamic and conventional banks in Yemen. A sample of 4 conventional banks and 3 Islamic banks was used during (2012-2017). Using Pearson correlation and regression analysis, the study concludes that there is a statistically significant relationship between credit risk and banking hedging and a strong statistically significant relationship between capital adequacy and banking hedging. Based on the type of bank, results indicate a negative relationship but no statistical significance between conventional banks' credit risk and banking hedging. There is a statistically significant relationship between credit risk and banking hedging of Islamic banks. Capital adequacy positively interacts with the banking hedging in both banks.
A scenario-based model of the reproduction of institutional sectors’ investment potential in Sverdlovsk oblast
Authors: Naumov Ilya
Published: November 2020

The article aims to resolve the methodological problems in the sphere of scenario planning of the reproduction of institutional sectors’ investment potential in regions. These problems are due to the complexity of accounting for multilateral financial relationships between sectors in the processes of the reproduction of their investment potential and the labour intensive assessment of the factors affecting their investment activities. Methodologically the study relies on the theoretical provisions of the scenario approach and the formation of balance models using the System of National Accounts. At the first stage, the presented methodological approach to scenario planning of the reproduction of institutional sectors’ investment potential suggests creating a matrix of financial flows moving between the sectors and examining the regularities of their investment potential reproduction. At the next stage, the approach offers a regression model of the cross-sectional relationships emerging in the course of the reproduction of the institutional sectors’ investment potential by various financial instruments taking into account the influence of internal and external factors. At the last stage, the approach develops a system of the most probable scenarios for the transformation of the reproduction processes of institutional sectors’ investment potential. It also entails a search for the most favourable scenario that increases the financial sustainability of the sectors and provides the regions with resources necessary for the implementation of the crucial infrastructure projects and strategic programs of the socio-economic development. The methodological tools and scenarios for the reproduction of institutional sectors’ investment potential in Sverdlovsk oblast developed in the study can be of interest to public authorities when framing the concept of the regional investment policy.
Measuring value created by business models in the sharing economy
Authors: Stepnov Igor , Kovalchuk Yulia
Published: November 2020

The sharing economy forms a modern sustainable trend, combining the economic and social-ethical benefits of using, rather than owning. The article studies such factors as social approval, economic choice and digital coordination influencing the effectiveness of business models of the sharing economy, but the full value of which has not yet been established. The methodological basis of the research includes neoclassical and neoinstitutional economic theories and the concept of economic collaboration. Among the research methods applied are a value-based approach to discussing the substance of collaborative consumption business models, a critical analysis of the peculiarities of the economic choice between saving and consumption, and a qualitative analysis of demand on the basis of a socially confirmed interest in collaborative consumption. The research develops five types of models for creating and redistributing income in the sharing economy and finds that the key advantage of the sharing economy is the confirmed demand of a new class of consumers, which reduces the probability of marketing mistakes. The authors state that any form of collaborative consumption for ensuring transparency of transactions and correctness of taxation should be regarded as a service. We design an alternative model for assessing the lower bound of the value created, which takes into account the frequency of consumers’ repeated requests to previously provided services, assuming that social approval shifts the line of choice and does not create a new value. The theoretical and practical significance of the research lies in the contribution to the value measurement of shared consumption based on consumer signals in the form of public approval (social initiative or testing) and profitability evaluation (lower bound) of the shared use by the consumer.
Application of Water Hyacinth Liquid Bio-Organic Fertilizer Using Trichoderma Sp Bio-activator on Growth and Production of Green Mustard Plants (Brassica rapa var. Parachinensis)
Authors: Aloatuan Febiayu , Maitimu Centhya Victorin
Published: November 2020

Mustard greens (Brassica rapa var. Parachinensis) are known vegetables among consumers and have high economic value. Besides being used as a vegetable, mustard greens are also used for the treatment of various diseases so that they are included in the vegetable group which has an important role in meeting the needs of food, nutrition and medicine for the community. To increase the growth and production of green mustard plants, it is necessary to apply liquid bio-organic fertilizers that are sourced from organic materials with good nutrients needed by plants, one of which is water hyacinth weed. To improve the quality of water hyacinth liquid bio-organic fertilizer, it can be applied with the bio-activator Trichoderma sp which functions to produce liquid bio-organic fertilizer with high nutrients for plant growth and production. The purpose of this study was to determine the growth of mustard greens including plant height, number of leaves and leaf width and to test the production of mustard greens including caratenoids and vitamin C content. This study used a completely randomized design (CRD) with a single factor, namely fertilizer. Liquid organic (POC) water hyacinth fermented using Trichoderma sp. which consists of 5 levels of fertilization doses, namely A (0 ml / L), B (8 ml / L), C (16 ml / L), D (24 ml/L) and E (32 ml/L) with 5 repetitions. Based on the results of analysis of variance, it showed that the dosage treatment of water hyacinth bio-organic fertilizer with the bio-activator Trichoderma sp had a significant effect on p <0.05 on plant height, leaf width and the number of green mustard leaves at 4 weeks of age 21 day after planting. with the results of the chemical content test which showed that treatment E (32 ml/L) contained Karetenoid (0,2596 mg/100g of material) and vitamin C (0.2784 mg/100 g of material). The best dose based on the results of the study was treatment E (32 ml/L) which had a higher average plant height, leaf width and number of leaves compared to other treatments and had high vitamin A and vitamin C content. To increase the growth and production of mustard greens and other horticultural cultivation processes, it is advisable to use liquid bio-organic fertilizer for water hyacinth with the bio-activator Thricoderma sp as an alternative to natural, environmentally friendly liquid organic fertilizer.
Can the Wondfo® SARS-CoV-2 IgM/IgG antibodies be used as a rapid diagnostic test?
Authors: Lysandro Pinto Borges , Makson Gleydson Brito De Oliveira , Daniela Raguer Valadão de Souza , Kezia Alves Dos Santos , Luana Heimfarth
Published: November 2020

Background: An outbreak of novel coronavirus (SARS-CoV-2) disease (COVID-19) has rapidly spread worldwide. The aim of this study was to evaluate and validate the performance of the Wondfo® lateral-flow immunochromatographic assay that detect SARS-CoV-2- IgG, IgM antibodies (Wondfo® IC), using the results obtained by the fluorescence immunoassay test as reference diagnostic. Material and methods: 97 serum specimens collected and analyzed by four independent laboratories of Sergipe/Brazil was used for validated the Wondfo® SARS-CoV-2 IgM/IgG antibodies test. The COVID-19 positive serum specimens were determined by fluorescence immunoassay technique, used as reference standard. Results: An overall of 97 serum specimens show 39 (39/97) SARS-CoV-2 IgG positive specimens, 33 (33/97) SARS-CoV-2 IgM positive specimen and 25 non-reagent specimens (25/97). However, the Wondfo® IC assay detected only 9 (9/97) IgM/IgG positive specimen and 25 (25/97) no-reagent specimen. A weak correlation was found between the outcomes of the Wondfo® IC assay and fluorescence test. The accuracy between the two tests was 32.08%. The sensitivity, specificity, positive predictive value, and negative predictive value of Wondfo® IC assay were of 11.12%, 100%, 100% and 25.27%, respectively. Moreover, no false positive sample was determinate, whereas 88.89% of false negative results were found. Conclusion: The Wondfo® IC test failed in providing a quick, valid, and reliable results and appears not to be a good alternative for clinical use in detecting pandemic coronavirus. However, if the limitations of the rapid test are known, some correction factors can be used in order to adjust the epidemiological data.
Preliminary design of a radio-controlled micro aircraft for student competition
Authors: Ali Dinc  , Yousef Gharbia  , Mariam AlShammari  , Aliah AlRasheedi  , Shahad AlQallaf  , Mayar AlIbrahim  , Shahad AlObaid
Published: November 2020

This work presents a preliminary design study of a radio-controlled micro aircraft. The aircraft is designed with the aim to compete in the SAE Aero Design Student Competition. Different designs were performed by different groups of students following the rules given in the SAE 2017 competition document. Such rules include the criteria of having the entire aircraft fit in a specific dimensional cylindrical box in unassembled condition, achieving the highest flight score and carrying the highest possible payload with minimum airframe weight, etc. In this scope, the concept generations of multiple designs for the micro aircraft with appropriate dimensions were done. In addition, basic paper prototypes of the designs which were helpful to visualize the aircraft were constructed. 3D CAD models of designs and 2D drawings for dimensional description were prepared. No prototypes were manufactured due to the Covid-19 situation.