bluuebunny/crossref_metadata_2025 huggingface dataset:
Major causes of negative and positive impacts on mental health during lock-down due to COVID-19 pandemic.
Authors: Izhan Ali Khan.  , Asima Khan  , Fauzia Imtiaz  , Mukarum Ali
Published: January 2024

Introduction: Soon after pandemic of Covid-19; Lockdown across Pakistan led to wide spectrum of problems that includes unemployment, closure of schools & Colleges, shattered economy. Least in focused remained the mental health of the people affected due to different reasons.

Objective: To determine the major causes of negative and positive impact on mental health during Covid-19 pandemic. of lock-down on mental health.

Methodology: This cross-sectional study was conducted at Dow University of Health Sciences during April-May 2020. Using structured online questionnaire, 362 participants took part in the study. The selection criteria were age above 14 years and resident of Karachi in an area under lock down due to pandemic of COVID-19.

Results: Overall, 95.3% participants agreed that lock down is most appropriate strategy to counter the spread of Covid-19. Stress consequent to lock down was attributed as concern for their loved ones and relative by 47% of the participants, social distancing and restrictions by 44.2% and fall in economic situation by 43.4%. When asked for the probable solutions to these problems; provision of grocery items at door steps was stated by 53%, ease on taxes and/or bills by 52.5%; while 51.7% were of the opinion that people should be keep informed about development regarding Covid-19.  The positive impacts on mental health were due to having more time for family (63.5%) and break from busy life (47.5%).

Conclusion: Different causes of negative and positive impacts of lock-down were acknowledged with people experiencing almost similar causes of stress and anxiety. Almost all of the problems are solvable if people’s recommendations are taken into account.

 

Keywords: COVID-19 19, pandemic, Mental health.
Forensic Evaluation of the patterns of fatal injuries among pedestrians in road traffic accidents in Hyderabad, Pakistan.
Authors: Mir Ghulam Ali Talpur  , Sadia Abdul Qayyum  , Amna Mangi  , Hari Ram  , Naveed Ali Qadri  , Abdul Waheed Ali Nahyoon
Published: January 2024

Introduction: Road traffic accidents (RTAs) preventable yet responsible for a large number fatalities among children and adults. It is estimated that RTA causes approximately 1.35 million deaths (27.5 deaths per 100,000 population) through out the world.Objective: To evaluate the patterns of fatal injuries among pedestrians due to road traffic accidents brought in emergency unit of Liaquat University, hospital, Hyderabad.Methodology: This cross-sectional study conducted between Jan 2019 to Dec 2019 and all victims of road traffic accidents brought in the emergency due to fatal injuries belongs to either sex or age-group were included. Data collected includes demographic details; type, site, impact, intensity of inju-ries and different types of vehicles involved in the accidents were recorded from history/ autopsy findings of medico-legal officer. Collected data was entered and analyzed in SPSS ver. 23.Results: Motorcars were more involved (31.0%) in road traffic accidents followed by trucks/loaders (29.0%). Males (87.5%) outnumber female. Head and neck region (26.0%) affected most, while abdomen/pelvis were the least(16.0%) affected. Contusions occurred in predominantly (51.0%) while most (60.5%) pedestrians were found dead when received in the emergen-cy unit. Most common cause of death was head injury induced complica-tions.Conclusion: Injuries to head, neck and facial regions are more common while contusions are the predominant type of injuries occur in the pedestri-ans. Skull bone is most commonly fractured bone among the victimsKeywords: Pattern of injuries, Pedestrians, Road traffic accidents .
Pattern and localization of headache in cerebral venous sinus thrombosis (CVST).
Authors: Hafiz Muhammad Zeeshan  , Sehar iqbal
Published: January 2024

Introduction: Cerebral Venous Sinus Thrombosis (CVST) is an underdiagnosed but not rare type of neurovascular disease. There is involvement of cerebral veins or dural sinuses instead of arteries. The vein or dural sinuses are blocked by thrombus resulting in increased pressure and leading to rupture of vessels and leakage of blood into the brain. Headache is the most frequent presenting symptom of CVST.Methodology: This descriptive study was conducted at Sheikh Zayed Medical Col-lege and Hospital Rahim Yar Khan. All consecutive patients with confirmed diagno-ses of CVST were included in the study. Diagnosis of CVST confirmed by MRI/MR Venogram. An informed consent was taken and the data was collected on a ques-tionnaire. Ethical permission was taken from Institutional ethical review com-mittee.Results: Headache was present in 51 (81%) of 63 confirmed CVST patients. Data regarding characteristics of headache from 51 patients was analyzed. The headache was associated with photophobia (4%), phonophobia (6%), loss of vision(6%), nau-sea (9%) and vomiting (42%) .The headache was not related with infarct and hem-orrhage on Computed Tomography scan and Magnetic Resonance Imaging. The site of headache was not linked with site of sinus thrombosis.Conclusion: Headache is the common symptom in patients with CVST. Usually the headache in CVST is subacute, throbbing, unilateral or localized to some specific region i.e frontal, temporal and occipital. There is no relation between headache and site of sinus thrombosis. Also there is no link between headache and hemor-rhage or infarct on Computed Tomography scan (CT) and Magnetic Resonance Im-aging (MRI).Key words: Cerebral Venous Sinus Thrombosis , Headache, MRI/MR Venogram.
Co-occurrence of sleeping difficulties with urbanization and food choice in female university students.
Authors: Jamshed Warsi  , Benazir Mahar  , Tazeen Shah  , Shafaq Ansari  , Muhammad Qasim Nizamani
Published: January 2024

Introduction: Sleep is a basic and essential need of human beings, large number of sleep related problems are demonstrated in all age groups with different pro-moting factor( s), these may be biological, social, economical or environmental. Literature is scanty to identify co factors of sleep disturbances in apparently healthy females.Objective: To analyze association of sleep disorders in females with rural/ urban settings of living and certain dietary habits.Methodology: A cross sectional /survey-based study was performed in University of Sindh Jamshoro. The sample size (n) was 520.The data comprised of females aged between 18 -26 years. Pittsburgh Sleep Quality Index (PSQI) was employed to assess sleep quality among the participants along with self-structured question-naire which was used for other variables such as consumption of junk food and its frequency of intake and breakfast intake.Results: Out of 520 participants, 310 (60%) were living in urban areas shows com-paratively higher frequency of poor sleep (n=262,50.5%; p=0.01-odd ratio=2.18) than those who were living in rural setups. Poor sleep was also observed in junk food eaters (n=304, 58%) however no association was observed in pattern of breakfast with sleep.Conclusion: The study concluded the prevalence of poor sleep was found more in urban female dwellers.Keywords: sleep, rural, urban, junk food, breakfast, Pittsburgh Sleep Quality Index (PSQI).
Risk factors for surgical site infection following cesarean section.
Authors: Paras Shah  , Rabia Jamil  , Nazia Ahmed  , Lubna Ali  , Tayyaba Ambreen
Published: January 2024

Introduction: Post caesarean section (CS) wound infections represents a considerable load for health system; therefore, preventive measures should be a health care priority in developing world.1 The rate of surgical site infection (SSI) after caesarean section is reported between 3% -15%.

Objective: To determine risk factors responsible for surgical site infection following caesarean section.

Methodology: This cross-sectional study was conducted at Department of Obstetrics and Gynecology Unit II Civil Hospital Karachi during January 2017 to June 2017. Total 163 women with post cesarean wound infection, irrespective of any age and parity, were included in the study. Post-surgery, final assessment was made after 30 days. Informed consent was taken and patients were inquired about history of trial of labor from Dai or lady health visitor (LHV), history of leaking of amniotic fluid, presence of maternal fever ≥100 for 24 hours, maternal leukocytosis >15000/mm3, uterine tenderness, foul odor of amniotic fluid and decreased Hemoglobin level. Women with history of diabetes and gestational diabetes, cesarean section performed in other settings and had undergone cesarean section via midline vertical incision were excluded. Findings were recorded in a self-designed questionnaire. SPSS Version 20 used to analyze the data.

Results: Mean age of women was 27.88±4.55 years. Most common factor for surgical site infection was personal hygiene (58.9%) followed by obesity (23.3%), history of LHV/Dai handling (20.2%), PROM (17.8%), anemia (13.5%) and chorioamnionitis (10.4%).

Conclusion: For surgical site infection, personal hygiene is more common risk factor.

Keywords: Risk actors, Surgical Site Infection (SSI), Caesarean Section.
Pattern of malignant hematological disorders using bone marrow aspirate and biopsy at tertiary care hospital, Karachi.
Authors: Mehwish Sajjad  , Shaheen Kouser  , Taha Khan  , Zaen Al Abideen  , Hira Qadir  , Mehreen Mehmood
Published: January 2024

Introduction: Bone marrow aspirate and biopsy is an invasive method for identification, staging, and pursuing tumors. Current study designed to determine the frequency of malignant hematological disorders using bone marrow aspirate and biopsy at Dr. Ishrat ul Ebad Khan Institute of Blood Diseases (DIEKIBD).Objectives: To determine the frequencies of various hematological disorders usingbone marrow aspiration and trephine biopsy examinationMethodology: In this retrospective study, 333 patients presenting at DIEKIBD during January 2019 to December 2020 were included. All these patients underwentbone marrow examination and the reports were retrieved from the departmentrecords.Result: It was observed that about 80 (24%) of the bone marrow examinationswere done for staging in which 8 (2.4%) were not illustrated any primary diseasesinvolvement while 72 cases (21%) contained primary diseases. Among nonmalignant conditions, iron deficiency anemia, megaloblastic anemia and mixed deficiency anemia were the most frequent, while acute lymphoblastic leukemia, acutemyeloid leukemia and chronic myeloid leukemia were the most prevalent malignanthematological disorders.Conclusion: Pathological analysis of Bone Marrow via Aspirate and Trephine biopsy is a widespread approach in diagnosing, staging and prognosis of neoplastic aswell as non-neoplastic hematological disorders. Bone Marrow biopsy examinationanalysis has a significant value in the diagnosis and staging of malignant conditionsthan non-malignant disorder as in our study prevalence of malignant conditionswere more than non-malignant diseases.

Key words: Bone Marrow Biopsy, Blood Disorder, Malignant Hematological Diseases.
The impact of covid-19 pandemic on dental practitioner.
Authors: Maham Shah  , Romesa Khero  , Nigah Imam Syed  , Muhammad Nazir  , Murk Razzaque
Published: January 2024

Introduction: The coronavirus has so far been spread all over the world and hin-dered all aspects of person's life. This pandemic has adversely affected the profes-sional life as well.Objectives: To assess the impact of epidemic COVID-19 on dental practitioners.Methodology: Dentist were invited to participate in the study through social media/email. 250 dentist who give consent were selected randomly to be included in the study. Participants were assured about anonymity of the personal information and informed consent taken. Data collected by using an online questionnaire and ana-lyze by using SPSS® version 22Results: Majority (80%) dentists were facing financial constraint, 72% dentist agreed that reopening of clinics could result in transmission of virus. More than half of the dentist agreed that watching/listening news of COVID-19 is causing depression and anxiety. Nearly all the dentist revealed that they usually feel symptoms mimicking that of Covid-19.Conclusion: Dentists due to the direct result of overwhelming fear, confusion and anxiety among dental staff, strengthened by the high perception of the risk of COVID- 19 contraction, had a significant reduction in dental clinical practice. The sudden decline in the number of dental procedures and the implementation of a new infection control protocol has caused financial problems for most dentists.

Keywords: COVID-19, Pandemic, dental practitioners.
Attitude of overseas Pakistani students towards modular examination.
Authors: Syed Mukkaram Ali , Mehreen Fatima  , Sahar Sharif  , Lubna Ali  , Fauzia Imtiaz  , Ahmed Moiz
Published: January 2024

Introduction: Modularization an innovative initiative taken by educational institutes around the globe to increase the student’s productivity and efficiency.

 

Objective: The objective of this study was to determine the knowledge and attitude regarding modularization in overseas Pakistani students.

Methodology: A cross sectional survey was conducted at the International Medical College of one of the public sector university during December 2012 till February 2014. A total of 425 undergraduate students were approached through non-probability convenience sampling technique and requested to fill a semi structured questionnaire after taking written consent.

Result: According to the outset of this paper a total of 425 students were questioned. Among the total 189 students were male (44.47%) and 236 were female (55.52%) out of which the majority belonged from North America/Canada (79.06%). A vast percentage (48.94) invested of about 2 hours of study daily. 63.06% of students believed modular examination to be a fair system and 32.94% of students thought it to be a failure to affect any educational standards. 36% of students blame stress/load for their poor result and 31.06% agrees with the lengthy syllabus being responsible for their down showing GPA’s. 43.06% of students face hardships because of irregular attendance. The major complaint of students (39%) was their teaching style. 46.12% of students prefer to study from lecture notes. Thus, this study completely clears all the aspects of student’s performance in modular system of examinations and its flow and shortcomings. It is important that more effort should be put into cater to student’s stress, loads and make it an effective system to improve a student’s capability and efficiency.

 Conclusion: The findings of this study can guide us to revise and reshape the assessment system practiced at various medical colleges in Karachi.
Implementation of hospital management information system (HMIS) in Muhammad Medical College Hospital (MMCH): Challenges & Opportunities for Management.
Authors: Bux Rahim , Ahmed Sheerin , Pathan Iqbal
Published: January 2024

Introduction: Since the recent revolution in the IT industry of Pakistan, hospitals are switching to automated information system (IS). Hospitals liked AKU, Indus Hospital, Shaukat Khanum Cancer Hospital are one of the examples of such change. The main purpose of using this technology is its transparency, efficiency and effectiveness in the delivery of services, but at the same time, implementation of such system in hospitals is also a big problem for management.

Methodology: A cross sectional descriptive study was conducted in different departments of Muhammad Medical College Hospital (MMCH), Mirpurkhas. 30 staff members including paramedics, accountants, supervisors and administrators were interviewed by using a closed ended questionnaire. The variables assessed were regarding knowledge, attitude, participation and willingness towards the implementation off HMIS at MMCH.

Results: 30 staff members were approached for interview, majority of them were between 20-30 years of age. Most were unaware about the intention of top management about the implementation of HMIS. 30% of staff had basic IT skills, however 20% were not able to demonstrate IT skill. The gap of communication during between stakeholders were also identified.

Conclusion: This study suggests MMCH should focus on improved planning and coordination between departments, capacity building through trainings and awareness sessions in employees to accept change and involve middle management in the process. The study further recommends hiring professional and qualified personnel in future recruitment process.

 

Key Words:

HMIS, MMCH, IT, IS, PMIS, MIS, Mirpurkhas
Complications of Laparoscopic cholecystectomy at Muhammad Medical College Mirpurkhas: Audit of 100 cases.
Authors: Muhammad Rahim Bhurgri  , Syed Razi Muhammad , Mehtab Rahim Bhurgri
Published: January 2024

Introduction: The main objective was to determine the complications of laparoscopic cholecystectomy (LC) and its cause at Muhammad Medical College Mirpurkhas.Methodology: This is prospective study carried out from February 2008 to January 2016. Data of all patients undergoing elective laparoscopic cholecystectomy during the study period and fulfilling the selection criteria was collected and entered in standard proforma and analyzed on SPSS 10.Result: A total number of ten patients underwent laparoscopic cholecystectomy with an overwhelming majority of females (87 out of 100). The age ranges from 22-60 years mean age being 38 years. The overall complication rate was 9%. The complication included bleeding (4/100, 4%) from cystic artery and gall bladder bed, port site infection (4/100 4%) One patient developed collection in pouch Morrison and one patient was developed stitch granuloma. There was no bile duct injury and colonic injury. The most common cause of these complications was accidental injury to cystic artery and gross spillage of infected bile.Conclusion: Bleeding and port site infections were common post-operative complication; the most common cause of bleeding was cystic artery injury whereas the commonest cause port site infection was gross spillage of infected bile.Key Words: Laparoscopic endoscopy, cholelithiasis, complications
Assessment of Mortality and Causes after Re-bleed In Patients Having Endoscopy for Upper Gastrointestinal Bleeding
Authors: Soomro Naeem Ahmed , Jokhio Abdul Rahman , Khan Amjad Ali , Sajid Ali
Published: January 2024

Introduction: Acute Upper gastrointestinal bleeding (AUGIB), with prevalence of 36 to 172/100,000 natives per year, is a common medical emergency. Mortality rate after UGIB ranges from 4–14% while re-bleeding is evident in 10–30% of these patients. Despite advances in treatment modalities of UGIB, the in-hospital mortality rate remains high and it is commonly due to re-bleeding. However, the causes and frequency of mortality among patients with re-bleeding are not well known in Pakistan.

Objective: To determine the frequency and causes of in-hospital mortality after re-bleeding among patients undergoing endoscopy for upper gastrointestinal bleeding.

Methodology:  A descriptive cross-sectional study was done in Military hospital Rawalpindi from December 2014 to June 2015. A total 150 patients aged between 18 to 65 years who presented with upper gastrointestinal bleeding (UGIB) and underwent upper GI endoscopy and re-bleed were included through purposive sampling. Structured questionnaire used to record data. The patients were observed for mortality and causes after re-bleeding in the hospital for about 5 days. Patients who died, the cause of the death was assessed by 2 senior consultant physicians. SPSS version 21 was used for data entry and analysis. Variables like mortality were presented as percentage and frequencies. Effect modifiers like age and gender were controlled by stratification.

Results:  The mean age of patients (n=150) was 43.97±12.28 years. Among total cases, 97 (64.7%) were males and 53 (35.7%) were females. The in-hospital mortality rate was 20% (n=30), re-bleed was cause in 12 (40%) while in 18 (60%) cause was other than re-bleed (cardiac, multi-organ failure, neurological, pulmonary, and advanced malignancy). Mortality in male patients was higher (n=18, 60.0%) as compared to female patients (n=12, 40.0%). The highest mortality (n=22, 73.3%) was observed in age group ˃43 years. The association of in-hospital mortality was statistically significant (p value = 0.02) by age but not by gender.

Conclusion: In-hospital mortality after UGIB is 20 %, frequent cause is other than the re-bleed. Male above aged 43 are more vulnerable. Management of UGIB should also focus on optimization of non-re-bleeding causes and other co-morbid related deaths instead of merely maintaining homeostasis and blood transfusions.

 

Keywords: Re-bleeding, Mortality, Acute Upper Gastrointestinal Bleeding, Upper GI Endoscopy.
Knowledge, Attitude and Practice regarding management of HIV /AIDS among Postgraduate Medical Internee working in Tertiary Hospitals of Karachi
Authors: Halo Liaquat Ali , Soomro Jamil Ahmed , Allah Bachayo Rajar
Published: January 2024

Introduction: In this modern era the number of new HIV infections has dropped; but Pakistan remains among few regional countries witnessing an increase in cases. On the other hand most, Pakistani people have inadequate knowledge regarding HIV/AIDS. In a study conducted in Pakistan concluded that it is a mutual misconception in overall population or society is that being Muslim, HIV cannot be contracted.Objective: To assess the knowledge, attitude, and practice about HIV/AIDS among post-graduate medical Doctor of Medicine Working in the tertiary care Hospitals of Karachi.Methodology: This descriptive cross-sectional study was done at three randomly selected tertiary care hospitals of Karachi. All the postgraduates’ medicine’s trainee of three hospitals were approached for data collection. The data was collected by the principal investigator through structured questionnaire based on 31 questions regarding knowledge, attitude, practice and management of HIV/AIDS patients by the participants. The study duration was 6 months. SPSS version 24 was used to analyze data.Results: The study showed that the one third of participants (35.3%) had adequate knowledge regarding HIV/AIDS, whereas large number of internees had adequate attitude (69.7%) towards HIV Patients, and almost one fourth participants had adequate practice and management (26.1%) approach towards HIV/AIDS cases.Conclusion: The Postgraduate internee has sufficient attitude, while poor knowledge and practices towards HIV/AIDS cases. To improve HIV/AIDS management strategy, it is highly recommended to create awareness among health care provider as well as general population through emphasis on all components of KAP.Keywords: KAP, HIV, AIDS, tertiary care hospital.
Determining the future direction of Curriculum reform process at a Public-Sector University in Saudi Arabia.
Authors: Syed Imran Mehmood
Published: January 2024

Introduction: Educational institutions have recognised the importance of evaluating academic curricula to keep up with dynamic changes in the field of medical education. The college of medicine at King Khalid University has acknowledged this trend and embarked on reviewing its curriculum.

Objectives: To evaluate the undergraduate medical curriculum using SPICES model of curriculum evaluation as a tool with the view to plan and shape future curriculum reforms at the college of medicine, King Khalid University.

Methodology: A questionnaire-based survey was conducted eliciting the responses of faculty members and the departmental chairmen regarding the practice of student centred, integrated and non-traditional teaching methods as well as a separate questionnaire for the quality of problem-based learning in practice. The compiled responses from all the respective departments were statistically analysed subsequently.

Results: An average of 43.5% of student-centred learning (SCL), 41% of Integrated teaching (IT) and 19% of Non-traditional teaching (NTT) is being employed in different departments of the college of medicine.

Conclusion: The results suggest that the college of medicine is currently carrying out traditional teacher centred, discipline based and information-oriented teaching along with small chunks of student centred, integrated and problem-based teaching methods. Although the problem-based learning is proportionately very small in practice but in general, its quality is better in the clinical departments as compared to the basic sciences departments.

 

Key words: Curriculum evaluation, curriculum review, medical education, educational strategies
Analysis of Differences in Consumer Perceptions of Service Quality from an Islamic Perspective (Study of Panorama Traditional Markets and Hypermart Modern Markets)
Authors: Aprina Nana , Isnaini Desi , Muttaqin Faisal
Published: January 2024

The purpose of this research is to determine the differences in consumer perceptions of service quality, namely: the direct evidence dimension (tangibles), the reliability dimension, the responsiveness dimension, the assurance dimension, and the empathy dimension in the traditional market "Panorama ” and the Modern Market “Hypermart”. To test this, researchers used quantitative methods with primary data collection techniques in the form of questionnaires distributed to 200 respondents. The data analysis technique used is an independent sample t-test using the SPSS version 25 program. From the results of the research and discussion, it was found that differences in consumer perceptions of service are found in the dimension of attention (empathy) with a significance value (sig-2-tailed) of 0.003 for the empathy variable. at a significance level of 5% this value is significant because the significance is 0.003 > 0.05 and for the dimensions of tangibles, reliability, responsiveness, and assurance there is no difference in perception because the significance value is greater than 0.05. With this research, it is known that there are differences in perceptions in the empathy dimension and it is hoped that this can become a benchmark for improving service performance.
Application of the Mudharabah Agreement in the Profit Sharing System for Raising Cattle (Study in Penago II Village, Ilir Talo District, Seluma Regency)
Authors: Nur Wahidah Titi , Asnaini Asnaini , Makmur Makmur
Published: January 2024

The purpose of this research is to find out how the application of the contract that has been running in Penago II Village, Ilir Talo Subdistrict, Seluma Regency and to find out the application of the mudharabah contract on the profit sharing of raising cattle in Penago II Village, Ilir Talo Subdistrict, Seluma Regency. This research uses a qualitative descriptive approach. Informants in the study were 8 people. Data collection techniques using observation, interviews, and documentation. Data analysis techniques use data reduction, data presentation and conclusion drawing. From the results of the research and discussion, it is concluded that the application of the contract that occurred in Penago II Village uses agreements and profit sharing, capital, profit sharing, risks and continuation of the contract if one of the parties dies, influencing factors, various types of cows that are in the field, and the time period. the agreement is only done verbally only trust each other in making this agreement, the profit sharing system in the mudharabah contract carried out between the owner and the manager in Penago II Village. With the division of the ratio divided 60:40. This occurs by agreement between the two parties. If in the process of this contract there is a loss, it will be borne by both parties, as long as the mistake is not due to the negligence of the manager. The profit sharing carried out by the people of Penago II Village is in accordance with the concept of mudharabah in Islamic Economics, namely, capital, management, collateral, time period and profit ratio to the manager. So that the profit sharing carried out by the people of Penago II Village is going well.
Development Status and Characteristics of Family Farms in China
Authors: Huang Yiqian , Wu Jun
Published: January 2024

China's family farm is formed under the constraints of China's small-scale peasant culture, the national conditions of large population and small land, and the land system. It is the product of agricultural transformation, the innovation of the previous decentralized and fragmented agricultural management mode and agricultural management mechanism, and the development and improvement of China's basic rural management system. Cultivating and developing family farms is an important orientation of China's agricultural policy in the new era, and an important part of realizing agricultural modernization and promoting rural revitalization. Family farms in China have both efficiency and scale advantages, which are more effective forms of management and organization for the development of agricultural production. From the overall development trend of family farms, it shows the evolution trend of diversification and enterprise, and diversification is embodied in horizontal combination and vertical integration.
Strategi Public Relations PT Pertamina Dalam Pengelolaan Krisis Komunikasi Pada Kasus Depo Pertamina, Plumpang
Authors: Puspaningtyas Raden Roro Nadya , Sumarni Lilik , Meitana Nabila Putri , Sulistia Imelda , Lisnawati Tamara , Libriyanti Silvana
Published: January 2024

The tragedy of the fire that occurred at the Pertamina Plumpang Depot in March 2023 resulted in casualties. This incident claimed lives, caused injuries, and led to facility damage and other losses. The root cause of the fire was attributed to various factors, primarily stemming from the use of petroleum products. In responding to this incident, PT Pertamina implemented a strategy that involved providing health assistance, accommodation, and food. Additionally, the company held a press conference on March 4th, 2023, and issued press releases through Pertamina's official YouTube channel. The objective of this research is to understand how Pertamina's crisis communication management unfolded during the Pertamina Plumpang Depot fire issue. The research employed a qualitative method with descriptive analysis. The findings and discussions in this study indicate that the Plumpang Depot fire crisis did not significantly damage the reputation and credibility of PT Pertamina. This was because the company successfully instilled a positive perception among the public, and Pertamina's Public Relations demonstrated responsiveness in handling the case.
Instauración de la marcha procesional en la música de tradición religiosa en la Lima de inicios del siglo XX
Authors: Chacón Salazar Marvin Humberto
Published: January 2024

Este trabajo explora cómo fue la configuración de las características formales e instrumentales del género musical marcha procesional en su proceso de instauración en la tradición musical limeña a inicios del siglo xx. Se contextualiza tal instauración en el marco de la tradición popular religiosa más concurrida de Lima que es la procesión del Señor de los Milagros, en la cual la banda de músicos es un componente social fundamental, cuya continuidad ha generado un importante repertorio, una forma musical propia y un formato instrumental específico, peculiar en la historia de la banda, pasando de esta manera de una concepción militar a una concepción sonora de carácter religioso y procesional. Un abordaje central en este estudio es el reconocimiento de los aportes del músico José Sabas Libornio Ibarra y del compositor Constantino Freyre Arámbulo a su llegada a Lima, y de cómo su labor dio inicio a la creación de obras con características musicales de forma e instrumentación específicas para la función religiosa. En este mismo sentido, se analiza el aporte directo de las bandas oficiales del país a la instauración de esta expresión musical en la tradición religiosa limeña.
INNOVATION OR ENTERPRISE RESOURCE PLANNING FOR EFFICIENCY OF HEALTHCARE MANAGEMENT: MIGRATION DATA PROGRESS
Authors: Liya Romayatul Liya Romayatul , Sari Putri Nur Indah , Yusroh Rafida Alifiyah , Saputra Muhammad Ganda
Published: January 2024

Data is an important component in a system/software/application. The ERP (Enterprise Resource Planning) system is a business software package system that aims to help companies automate and integrate most business processes, share data and activities within a company, create and access information from the environment in a relevant, accurate and timely manner. This activity is a service program in the form of apprenticeship to partners, namely PT X with a jobdesk in the form of migrating company data into an ERP (Enterprise Resource Planning) system with the aim of forming an ERP (Enterprise Resource Planning) information system that helps the service process be more effective and efficient. This activity was carried out for 6 months, namely July-December 2023. One of the obstacles in the data migration process that took place was speed disturbances in the system, especially if used simultaneously. Implementation of an ERP-based data input process system at PT X can be expected to minimize the occurrence of human error which can result in errors in identifying subsequent data management. So the output obtained will be more accurate.
Etika Kristen tentang Standar Mengasihi Berdasarkan 1 Yohanes 4:18-21 dan Penerapannya oleh Orang Percaya di Media Sosial
Authors: Waruwu Junieli
Published: January 2024

Etika Kristen diambil dan ditarik dari pendalaman akan firman Tuhan untuk dipergunakan sebagai standar berperilaku dan bertindak baik dalam dunia nyata maupun dalam dunia maya. Tidak dapat dihindari bahwa masyarakat kita memiliki dua dunia yaitu dunia nyata dan dunia maya. Masyarakat menyukai dunia maya karena mampu mengekspresikan diri secara bebas tanpa aturan yang mengikat. Kebebasan ini menimbulkan berbagai permasalah yang memicu hilangnya nilai kasih sebagai perintah utama Tuhan Yesus Kristus bagi pengikut-Nya. Orang percaya sering bertindak gegabah dengan mengujarkan kebencian, kritik tanpa solusi, dan kadang menghina karena jengkel dengan suatu pernyataan tertentu yang kadang juga dilanjutkan dalam dunia nyata. Hilangnya rasa mengasihi merupakan tantangan bagi orang percaya. Penelitian ini menggunakan penelitian kualitatif dengan fokus pada kajian literatur untuk menemukan standar mengasihi sebagaimana ditegaskan kembali dalam 1 Yohanes 4:18-21. Dari penelitian yang dilakukan ditemukan hasil bahwa setiap orang percaya memiliki standar mengasihi sesama sekalipun tidak kelihatan dengan hati yang tulus, mengasihi dengan segenap akal budi, mengasihi seperti mengasihi diri sendiri, serta tidak takut dengan perkembangan teknologi, tetapi justru melihat bagaimana perspektif Allah mengasihi sesama sesuai dengan perkembangan masyarakat digital.
The Exploration of Emotional Aspects of Artificial Intelligence (AI) in Artistic Design
Authors: Zhao Wenbo , Sun Yuanyuan
Published: January 2024

The article explores the emotional aspect of artificial intelligence in art and design. With technological advancements, AI has shown tremendous potential in the realm of artistic creation. Firstly, the article reviews the development of AI in art and design, introducing applications of technologies such as generative art, deep learning, and generative adversarial networks. Secondly, it delves into the emotional dimension of AI in artistic design. Despite significant progress in learning and imitating artistic styles, AI's expression of emotions remains limited to simulating programs and data, creating a gap with human emotional experiences. However, by learning from human aesthetic experiences, AI utilizes universally recognized emotional symbols in artistic works, evoking aesthetic resonance among audiences. Furthermore, the article emphasizes the importance of human designers in the creative process and the potential for collaboration between AI and humans. Lastly, it discusses the future possibilities wherein AI, as technology advances, may enter an era of strong artificial intelligence, potentially disrupting the ecosystem of art and design. Although AI might acquire emotional and creative capabilities in the future, the emotional experiences and unique creativity of human creators remain irreplaceable. Therefore, the future of art and design might be a product of collaboration between humans and AI, opening new spaces for exploration and contemplation in the art world.
On Unplanned Educational Activities in the Preschool
Authors: Andersen Elisabeth Muth , Brouwer Catherine E. , Kristiansen Elisabeth Dalby , Pilesjö Maja Sigurd
Published: January 2024

This article concerns a learning environment in a preschool which includes a preschool teacher and two bilingual children. The article details how an activity of counting is introduced in the course of packing up a game and increasingly turns into an activity of calculation. Thereby the activity engages the participants to demonstrate their competences in terms of language and mathematics rather than (merely) manipulating, arranging and counting objects.  The analysis thus exemplifies how, by the use of language as a resource, an interaction in a preschool occasions an activity that may be seen as aiming at a transition between preschool and primary school. Simultaneously, however, it becomes clear that, possibly because this is an unplanned activity, the outcome of this activity may be unequally beneficial for the participants.
Nurses' and Nursing Students' Perceptions Toward People Living with Obesity: A Scoping Review Protocol
Authors: Duval Karyne , Couturier Élise , Laferrière Marie-Claude , Gagnon Marie-Pierre , Gallani Maria Cecilia
Published: January 2024

Introduction: There is significant and pervasive weight bias, weight stigma, and weight-based discrimination everywhere today, even in healthcare settings. Studies have shown that health care professionals (HCPs) hold negative perceptions toward people living with obesity (PLO), which results in heightened health risks for patients. Nurses play a central role in health promotion and the health management of PLO. Thus, identifying nurses' and nursing students' perceptions toward PLO within healthcare practice or educational contexts is paramount to consider further exploratory and intervention studies.

Objective: We aim to review and map nurses' and nursing students' perceptions toward PLO from available literature.

Method: A search of MEDLINE via PubMed, CINAHL Plus with Full Text (EBSCOhost), and PsycINFO (OVID) will be conducted to identify relevant studies in English, French, Spanish, Portuguese, or Italian on nurses' and nursing students' weight bias. The period covered will be from January 1, 2005, onward, including those available up until our scheduled search in January 2024. Two independent reviewers will conduct screening, study selection, and data extraction. Data will be charted according to the study design, the research setting, years and regions of publication, concepts, and use of theoretical models. The results will be summarized and reported, identifying implications for nursing research and practice.

Discussion and Research Spin-offs: This scoping review will inform nursing research and facilitate the development of educational and clinical tools aimed at preventing and reducing weight bias among nurses to promote nursing and interdisciplinary care that upholds principles of equity, diversity, and inclusion.
Lytiškumo sampratos Gyvenimo įgūdžių bendrojoje programoje vertinimas Katalikų Bažnyčios mokymo aspektu
Authors: Obelenienė Birutė , Narbekovas Andrius
Published: January 2024

Straipsnyje keliama problema, kad lytiškumo samprata yra pasaulėžiūrinė, parodoma, kad naujoji Gyvenimo įgūdžių bendroji programa (GĮBP), kurią Švietimo, mokslo ir sporto ministras patvirtino 2022 m. rugpjūčio 24 d., yra nesuderinama su Katalikų Bažnyčios mokyme (KBM) pateikta žmogaus lytiškumo samprata. Išgryninus lytiškumo kategorijas pagal KBM, buvo atliktas GĮBP lytiškumo sampratos vertinimas ir nustatyta, jog GĮBP lytiškumo samprata neatitinka nė vienos iš išgrynintų keturių lytiškumo kategorijų. Ši programa parengta nesivadovaujant binarine lyčių sistema, joje lytiškumas priskirtas pasiekimų sričiai (Saugus ir sveikas asmuo), kurioje nagrinėjamos žmogaus sveikatai pavojingos situacijos, todėl galima konstatuoti, jog GĮBP iš esmės neatitinka KBM lytiškumo sampratos nei jos ugdymo principų bei lytiškumo ir žmogaus sampratos Katalikų tikybos programoje. Tai kelia labai rimtą susirūpinimą dėl katalikų tėvų teisių ugdyti vaikus pagal savo įsitikinimus.
Письмо академика Льва Игорева от 5 (17) декабря 1860 года о положении католиков в Китае
Authors: Bilotas Viktor
Published: January 2024

Publikuojamas akademiko Levo Igorevo (1822–1894) laiškas apie 1860 metų įvykius Kinijoje ir apie katalikų padėtį šalyje naudingas bei įdomus ne tik sinologams ir Bažnyčios istorikams, bet ir tarptautinių bei tarpreliginių santykių tyrinėtojams, tapybos ir fotografijos istorikams. Šis šaltinis vertingas todėl, kad jame paminėta nemažai svarbių istorinių asmenybių, faktų, detalių, susijusių su katalikybe Kinijoje: parapijiečiais, dvasininkais, misijomis, šventyklomis, pamaldomis. 1896 metais išleistų akademiko Igorevo atsiminimų kontekste jo Pekino laiškas praplečia ir patikslina žinias apie 1860-ųjų Kiniją, apie šalies katalikų gyvenimą. Laiško originalas saugomas Irkutsko srities valstybiniame archyve, Irkutsko Romos Katalikų Bažnyčios fonde ir greičiausiai buvo adresuotas klebonui Kristupui Švirmickui (1812–1894), kilusiam iš Suvalkijos, vadovavusiam vienai iš didžiausių parapijų pasaulyje 1856–1894 m.
Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
Authors: Watabe Tetsuya , Yamahira Shinya , Takakura Kanako , Thumkeo Dean , Narumiya Shuh , Matsuda Michiyuki , Terai Kenta
Published: January 2024

Prostaglandin E2 (PGE2) is a key player in a plethora of physiological and pathological events. Nevertheless, little is known about the dynamics of PGE2 secretion from a single cell and its effect on the neighboring cells. Here, by observing confluent Madin–Darby canine kidney (MDCK) epithelial cells expressing fluorescent biosensors, we demonstrate that calcium transients in a single cell cause PGE2-mediated radial spread of PKA activation (RSPA) in neighboring cells. By in vivo imaging, RSPA was also observed in the basal layer of the mouse epidermis. Experiments with an optogenetic tool revealed a switch-like PGE2 discharge in response to the increasing cytoplasmic Ca2+ concentrations. The cell density of MDCK cells correlated with the frequencies of calcium transients and the following RSPA. The extracellular signal-regulated kinase (ERK) activation also enhanced the frequency of RSPA in MDCK and in vivo. Thus, the PGE2 discharge is regulated temporally by calcium transients and ERK activity.
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Authors: Kılıç Ayşe , Halu Arda , Marzio Margherita De , Maiorino Enrico , Duvall Melody G. , Brueggemann Thayse , Quintero Joselyn J. Rojas , Chase Robert , Mirzakhani Hooman , Sungur Ayse Özge , Koepke Janine , Nakano Taiji , Peh Hong Yong , Krishnamoorthy Nandini , Abdulnour Raja-Elie , Georgopoulos Katia , Litonjua Augusto A. , Demay Marie B. , Renz Harald , Levy Bruce D. , Weiss Scott T.
Published: January 2024

Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (1). Vitamin D supplementation studies do not provide insight into the molecular genetic mechanisms of vitamin D mediated immunoregulation. Here we provide evidence for vitamin D regulation of two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, reliably associated with autoimmune and chronic inflammatory diseases (2–4). We demonstrate increased vitamin D receptor (VDR) expression in mouse lung CD4+ Th2 cells, differential expression of Chr17q12-21.1 and Chr17q21.2 genes in Th2 cells based on vitamin D status and identify the IL-2/Stat5 pathway as a target of vitamin D signaling. Vitamin D deficiency caused severe lung inflammation after allergen challenge in mice that was prevented by long term prenatal vitamin D supplementation. Mechanistically, vitamin D induced the expression of the
Ikzf3
encoded protein Aiolos to suppress IL-2-signaling and ameliorate cytokine production in Th2 cells. These translational findings demonstrate mechanisms for the immune protective effect of vitamin D in allergic lung inflammation with a strong molecular genetic link to the regulation of both Chr17q12-21.1 and Chr17q21.2 genes and suggest further functional studies and interventional strategies for long-term prevention of asthma and other autoimmune disorders.Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
Noncanonical usage of stop codons in ciliates expands proteins with Q-rich motifs
Authors: Chuang Chi-Ning , Liu Hou-Cheng , Woo Tai-Ting , Chao Ju-Lan , Chen Chiung-Ya , Hu Hisao-Tang , Hsueh Yi-Ping , Wang Ting-Fang
Published: January 2024

Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins. SCDs often are intrinsically disordered regions that mediate protein phosphorylation and protein-protein interactions. PolyQ and polyQ/N tracts are structurally flexible sequences that trigger protein aggregation. We report that due to their high percentages of STQ or STQN amino acid content, four SCDs and three prion-causing Q/N-rich motifs of yeast proteins possess autonomous protein expression-enhancing activities. Since these Q-rich motifs can endow proteins with structural and functional plasticity, we suggest that they represent useful toolkits for evolutionary novelty. Comparative Gene Ontology (GO) analyses of the near-complete proteomes of 27 representative model eukaryotes reveal that Q-rich motifs prevail in proteins involved in specialized biological processes, including
Saccharomyces cerevisiae
RNA-mediated transposition and pseudohyphal growth,
Candida albicans
filamentous growth, ciliate peptidyl-glutamic acid modification and microtubule-based movement,
Tetrahymena thermophila
xylan catabolism and meiosis,
Dictyostelium discoideum
development and sexual cycles,
Plasmodium falciparum
infection, and the nervous systems of
Drosophila melanogaster, Mus musculus
and
Homo sapiens
. We also show that Q-rich-motif proteins are expanded massively in ten ciliates with reassigned TAA
Q
and TAG
Q
codons. Notably, the usage frequency of CAG
Q
is much lower in ciliates with reassigned TAA
Q
and TAG
Q
codons than in organisms with expanded and unstable Q runs (e.g.,
D. melanogaster
and
H. sapiens
), indicating that the use of noncanonical stop codons in ciliates may have coevolved with codon usage biases to avoid triplet repeat disorders mediated by CAG/GTC replication slippage.
Immortalization of American miniature horse-derived fibroblast by cell cycle regulator with normal karyotype
Authors: Tani Tetsuya
Published: January 2024

Immortalized cells serve as a crucial research tool that capitalizes on their robust proliferative properties for functional investigations of an organism. Establishing an immortalized American miniature horse cell line could yield valuable insights into these animals’ genetic and physiological characteristics and susceptibility to health issues. To date, immortalized small horse cells with normal karyotypes have not been established. In this study, we successfully established primary and immortalized fibroblast cell lines through the combined expression of human-derived mutant cyclin-dependent kinase 4 (CDK4R24C), cyclin D1, and Telomerase Reverse Transcriptase (TERT), although CDK4R24C and cyclin D1, SV40T and TERT did not result in successful immortalization. Our comparison of the properties of these immortalized cells demonstrated that K4DT immortalized cells maintain a normal karyotype. Ultimately, our findings could pave the way for the development of targeted interventions to enhance the health and well-being of American miniature horses.