bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptation of the Russian Accounting System for non-financial assets in accordance with the International Public Sector Accounting Standards: A problem analysis. Part 1
Authors: SAKHAPOV Bulat R.
Published: April 2024

Subject. This article analyzes the areas of concern of accounting for non-financial assets in State-funded (municipal) and autonomous institutions in accordance with the International Public Sector Accounting Standards.
Objectives. The article aims to identify and analyze the areas of concern associated with the adaptation of the Russian system of accounting for non-financial assets in accordance with the International Public Sector Accounting Standards based on a comparison of the main provisions of the International Financial Reporting Standards and the Russian Federal Accounting Standards for the public sector.
Methods. For the study, I used the methods of comparison, systematization, and data generalization.
Results. The article systematizes the main theoretical approaches to the study of issues in the field of adaptation of the Russian system of accounting for non-financial assets in accordance with the International Public Sector Accounting Standards.
Relevance. The results of the study and the theories of adaptation of the Russian system of accounting for non-financial assets in accordance with the International Public Sector Accounting Standards can be used for the theoretical study of this issue, as well as in practical activities in State-owned (municipal) publicly-funded and autonomous institutions.
Assessment of the industrial potential of Russia's industrial regions: Economic security
Authors: SMIRNOVA Ol'ga P. , CHESNYUKOVA Lyudmila K.
Published: April 2024

Subject. This article discusses the issues of ensuring economic growth, rational use of production assets and labor resources.
Objectives. The article aims to analyze the trends in the implementation of the industrial potential of some regions of Russia for the period 2017–2021.
Methods. For the study, we used a statistical analysis.
Results. The article breaks down Russian regions by level of industrial potential. Particular attention should be paid to such industrial policy instruments as an active reduction in imports, attracting domestic and foreign investment.
Relevance. The results of the study can be used to design a long-term programme for the development of the real sector of the Russian economy.
Science and technology capacities of the region – Some particularities and methodological approaches to empirical assessment: Evidence from the Volga (Privolzhsky) Federal District regions
Authors: GAFAROV Marat R.
Published: April 2024

Subject. This article discusses the issues of structural transformation of economic processes, competitiveness growth, and rational use of labor, financial and technological resources.
Objectives. The article aims to conduct a factor analysis of data reflecting the development potential of the Volga (Privolzhsky Federal District regions within the framework of the exogenous model of economic growth.
Methods. For the study, I used the economic and mathematical research methods.
Results. The article presents a developed system of equations to assess the impact of the qualitative characteristics of the science and technology capacities of regions on the economic growth change.
Relevance. The results of the study can be taken into account when developing programmes for the science and technology development of regions in the context of transition to a new technological paradigm.
Examination-Related Stress Leads to Temporomandibular Joint Disorders in Medical and Dental Students - An Institutional-Based Study
Authors: Mubeen Wisha , Khalid Mariyam , Kamran Aliza , Izhar Faisal , Tanvir Maha , Hassan Shafia
Published: April 2024

Background and Objective: Stress-related behaviors such as challenging academic atmosphere and rigorous examinations exert a negative impact on the normal function of temporomandibular joint. This study aimed to determine the prevalence and severity of temporomandibular joint disorders (TMDs) and their association with examination-related stress among medical (Bachelor of Medicine and Bachelor of Surgery) and dental (Bachelor of Dental Surgery) students.

Methods: This cross-sectional survey was conducted at Fatima Memorial Hospital, College of Medicine and Dentistry, Lahore, Pakistan, from June 2022 to November 2022 using the Fonseca’s Questionnaire. A total of 198 medical and dental students were included as study participants. They were required to select just 1 response for each of the 10 items mentioned in the adopted but customized and validated questionnaire. TMD was categorized as mild, moderate, severe, or no TMD based on the sum of these responses. The data were analysed using statistical software and a p-value less than or equal to 0.05 was set as significant.

Results: There were 52 (26.2%) males and 146 (73.7%) females with a mean age of 24.2 +1.22 years. Among 198 students, 104 were dental students while 94 were medical students. The prevalence of TMD was found to be 63.6% among all students. There was no TMD in 36.4% of students while 42.9% of students had mild TMD, and moderate and severe TMD was found in 14.1% and 6.6% of students, respectively. Mild (74%) and severe (6.7%) TMD were more prevalent in dental students than in medical students while moderate TMD was found more in medical students (16%). However, these differences were statistically not significant between dental and medical students (p > 0.005).

Conclusion: TMD was found in both medical and dental students with no significant difference in severity between them. The study indicates the need to take on certain preventive and therapeutic strategies to address this disorder among anxiety-prone medical and dental students.
Comparison of Functional Outcomes of Two Different Rubber Dam Systems in Dental Practices
Authors: Waheed Aqsa , khokhar Shehrayar akhtar , Sarwar Nosheen , Asif Sheejia , Minhal  , Shar Mor Khan
Published: April 2024

Background and Objective: The rubber dam is the only method that can ensure complete isolation during dental procedures. During endodontic and restorative procedures, it improves patient protection, treatment efficacy, and infection control. A novel rubber dam system called Optradam has introduced a remarkably comfortable, user-friendly clamp-free technique. Therefore, this study was conducted to compare conventional rubber and OptraDam®Plus (Ivoclar Vivadent) based on patients’ and dentist preferences.

Methods: After receiving ethics board clearance, this trial was carried out at the Department of Operative Dentistry at a tertiary care hospital in Islamabad from June to December 2022. A total of 30 participants were assigned to each group; conventional rubber dam (Group-1) and OptraDam®Plus (Group-2). Two questionnaires were designed and validated one to be completed by dental practitioners and the other by patients. The gathered information was analyzed using statistical tests of significance.

Results: A total of 60 patients were treated; 31 (52%) males and 29 (28%) females with a mean age of 32.35 years (SD = 4.59). Both the dentists (80% ) and the patients (73.3%) favored the conventional rubber dam system (Group-1). Concerning patient comfort, the conventional rubber dam (96.7%) was considered more comfortable than the OptraDam®Plus (Group-2) (86.7%). More effective moisture management was seen in Group-1 patients (90%). Other factors, such as time, convenience of application, and imaging radiography, had statistically insignificant results among both groups.

Conclusion: The results indicate that both patients as well as operators, preferred the use of conventional rubber dams over OptraDam®Plus during an endodontic and restorative procedure.
The Disconnect Between Policy Makers And Researchers – Time To Build Bridges
Authors: Zaheer Asad
Published: April 2024

According to World Health Organization, Pakistan and Afghanistan are the last bastions of Poliomyelitis. Rest of the world has become Polio Free. They achieved this freedom after becoming part of Polio Eradication Initiative which was created in 1988 just after the World Health Assembly resolved to eradicate Polio Myelitis from the globe. The woes of Pakistan do not end here. According to “Health Financing Progress Matrix Assessment Pakistan 2023. Summary of findings and recommendations” by World Health Organization, the service coverage index of Pakistan despite showing a consistent surge over the years was still significantly lower with a score of 45 against an average of 58 amongst the low middle income group countries in year 2021. This calls for a need to revisit our strategic policy making in all spheres of life but especially in health and health education. Dr Vaqar Ahmed in Pakistan’s Agenda of Economic Reforms, identified that this country faces a serious and lingering lack of institutional arrangement within our framework for research-based policy formulation, and post implementation feedback.
Políticas de avaliação (externa) da educação não superior no Brasil e em Portugal
Authors: Peluchen Camargo Vanessa Rosana , Schneider Marilda Pasqual
Published: April 2024

Trata-se aqui dos resultados de um estudo relacionado aos modelos de avaliação externa de duas realidades distintas, as de Brasil e Portugal. O objetivo é analisar experiências de avaliação externa na educação não superior e buscar tendências nos modelos em curso nos dois países. Considerando os pressupostos que informam os estudos comparados, procura-se destacar singularidades, heterogeneidades e homogeneidades dos modelos de avaliação externa praticados. Em termos conclusivos, embora o processo histórico de cada país seja determinante na constituição das suas singularidades, persistem tendências à adequação das finalidades das avaliações externas às demandas da globalização neoliberal com a implementação de mecanismos de accountability associados às avaliações externas nacionais.
Palavras-chave: Políticas de avaliação externa. Educação não superior. Estudos comparativos.
Nilai-Nilai Pembangun Karakter Dalam Ajaran Hindu
Authors: Trisna Sintyadewi Putu
Published: April 2024

Tujuan penulisan ini untuk mengalisis secara mendalam mengenai ajaran karakter yang merupakan perilaku yang tampak atau dimiliki  oleh masing-masing manusia yang dapat dilihat dalam tindakan maupun sikap kepada semua orang berlandaskan ajaran agama atau kebenaran. Perilaku yang tampak ini akan terlihat jelas dan bisa dipengaruhi oleh berbagai hal seperti hal positif maupun hal negatif seseorang tergnatung bagaimana lingkungan tersebut memberikan pengajaran pemahaman dari ajaran karakter melalui nilai-nilai yang wajib diketahui oleh semua manusia. Sebab karakter cerminan nilai-nilai yang terbentuk dalam diri kita masing-masing yang didapat melalui pendidikan, pengalaman, serta pengaruh lingkungan.  karakter tentu memiliki nilai-nilai yang bertujuan untuk memberikan pemahaman sekaligus dijadikan pedoman dalam menjalani kehidupan dimana saja dan kapan saja. Pentingnya tulisan agar dapat menganalisis dari nilai-nilai pembangun karakter pada ajaran Hindu karena melalui nilai-nilai inilah yang akan menjadi jembatan penghubung setiap orang agar menciptakan pribadi yang baik, berguna serta bermanfaat bagi dirinya sendiri maupun orang lain.

Kata kunci: Nilai-Nilai Karakter, Ajaran Hindu
Unfair competition: problems of criminalization of acts and differentiation of responsibility for their commission
Authors: Danilovskaia Anna Vladimirovna
Published: April 2024

The subject of the study is the problems of criminalization of unfair competition and differentiation of criminal liability for its implementation. In particular, the following issues are analyzed: the current state of criminalization of acts provided for in art. 128.1, 146, 147, 180, 183, 185.3 and 185.6 of the Criminal Code of the Russian Federation, the signs of which correspond to a certain extent to the prohibitions of the Federal Law "On Protection of Competition"; legislative techniques in the design of their compositions; qualifying and especially qualifying signs, sanctions provided for the commission of crimes of the specified group; practices in the field of application of the listed articles of the Criminal Code of the Russian Federation, including in countering unfair competition. The purpose of the work is to identify the problems of criminalization of acts that have signs of unfair competition, violations of legislative technique, shortcomings in the differentiation of criminal liability for their commission, and identify ways to eliminate them. The research methodology is based on general scientific and private scientific methods of cognition, dialectical, logical, formal legal, comparative legal, hermeneutic research methods, as well as methods of legal modeling and legal forecasting are used. The scientific novelty lies in the analysis of the problems of constructing the elements of crimes provided for in art. 128.1, 146, 147, 180, 183, 185.3 and 185.6 of the Criminal Code of the Russian Federation as a whole and in connection with their content with violations of the prohibitions contained in Articles 14.1-14.8 of the Federal Law "On Protection of Competition", proposals on criteria for criminalization of acts, research qualifying (especially qualifying) signs and sanctions as means of differentiating criminal liability, as well as in proposals for their improvement. The conclusions are based on the absence in the Criminal Code of the Russian Federation of a clear mechanism for protection against unfair competition, ideas about changing legislation aimed at establishing specific grounds for criminal liability for unfair competition, unification of qualifying signs and the proposal as a sanction of penalties and their sizes uniform for the entire group of criminal forms of unfair competition, as well as the extension to crimes, provided for in Articles 180, 185.3 and 185.6 of the Criminal Code of the Russian Federation, the institution of confiscation.
Ministry in the Tempest: A Reconstruction of the Life, Work, and Legacy of Rev. Andrew. Ndhlela of the Methodist Church in Zimbabwe
Authors: Mujinga Martin
Published: April 2024

This paper focused on the gap in the historiography of Methodism, where the legacy of Rev. Andrew Ndhlela was undermined. Ndhlela was appointed the first native District Chairman and General Superintendent of Rhodesia Synod in 1965 and later president of the Conference in 1977. The first appointment coincided with the Unilateral Declaration of Independence of Rhodesia imposed by Ian Smith, which created a crisis between the country and the church and between the Africans and the Europeans. This schism resulted in tensions, frustrations, and mistrust in the country and the church. Politically, Ndhlela saw himself leading a church divided based on the tensions between  Rhodesia and Britain’s relationship. Ecclesiastically, his appointment also caused conflicts as some Europeans felt that the natives were not yet ready for such leadership positions, and others felt belittled to be led by natives. Although  Ndhlela succeeded in leading the church in these tempest times, the historiography of the Methodist Church in Zimbabwe did not pay particular attention to a man who was the dividing line between the first and second phases of Methodist history. Using qualitative research methodology, the paper aimed at reconstructing Ndhlela's life, work, and legacy, focusing on how he maintained the church together when there was a possibility of splitting. The paper concluded by challenging the Methodist Church in Zimbabwe to honour the legacy left by Ndhlela of a united, inculturative, autonomous, and self-sustained church in the context of sociopolitical and religious conflicts.
Association between insufficient venous systems and clinical manifestations in chronic venous disease of the lower limbs
Authors:   Universidad César Vallejo, Mendoza Rojas Hubert J. ,   Hospital III de Emergencias Grau (EsSalud)
Published: April 2024

Introduction: The clinical, etiological, anatomical, and pathophysiological classification (CEAP) standardizes the manifestations of lower limb venous disease. Objective: To investigate the association between insufficient venous systems and the clinical classification of CEAP. Methods: A quantitative, cross-sectional, analytical, correlational study was conducted. Sampling was non-probabilistic and convenience-based. The sample size was 136 lower limbs from 71 patients. Chi-square, Monte Carlo and Odd ratio (OR) statistical tests were used with 95% confidence intervals through bivariate logistic regression (p<0.05). Results: 71.8% of the subjects were female, with an average age of 66.1 years. The most frequent insufficient venous system was the superficial system, present in 61.7% of cases. 100% of the dilated great saphenous veins (GSV) had insufficiency. The most common CEAP clinical class was C2 (44.9%); 35.1% of C1 (telangiectasia) cases had an insufficient venous system; 50% of C2 cases had GSV insufficiency (p=0.227). There was an association between the insufficiency of both superficial and deep venous systems and the CEAP clinical classification (p=<0.001). The deep venous system was associated with severe chronic venous disease of the lower limbs, OR (6.04) with a 95% CI (1.02-35.73) and p=0.047. Conclusions: The study demonstrated an association between the insufficiency of both superficial and deep venous systems and the CEAP clinical classification. One third of the lower limbs with C1 (telangiectasias) had an insufficient venous system.
Efeito antimicrobiano do ácido ferúlico: uma revisão integrativa de bioensaios
Authors: Nunes Mayara Karla dos Santos , Chaves Júnior José Venâncio , Souza Fábio Santos de , Andrade Patrícia Néris , Castro Ricardo Dias de , Pêssoa Hilzeth de Luna Freire , Sá Rita de Cássia da Silveira e
Published: April 2024

Objetivo: Identificar na literatura científica ensaios biológicos, in vitro, sobre a ação antimicrobiana do ácido ferúlico (FA). Métodos: O presente estudo trata-se de uma revisão integrativa da literatura, especialmente na base de dados PUBMED. Optou-se por realizar um estudo no período dos últimos 5 anos por conta das atualizações sobre a temática abordada. Resultados: Foram identificados um total de 682 nas base de dados, perfazendo uma amostra final de 09 trabalhos para a construção deste artigo. Atualmente as pesquisas no campo desenvolvimento de novos antimicrobianos com FA estão voltados a área de   biomateriais. Sabe-se que o biomaterial que vem sendo mais utilizado nos estudos é a quitosana. Nesta revisão, 66,6% dos artigos selecionados contemplaram o uso de biofilmes e conjugados de FA e quitosana. As análises microbiológicas incluíram testes de concentração inibitória mínima e bactericida mínima. Foi possível verificar que o FA quando associado a quitosana apresenta melhor ação frente às cepas microbianas testadas. Considerações finais: O FA conjugado com a quitosana mostrou potenciais perspectivas de aplicação. No entanto, se faz necessário, mais pesquisas no âmbito multidisciplinar para o desenvolvimento de antimicrobianos e antibacterianos, que atualmente, são uma ameaça crescente à saúde global.
Exploring the spectrum of vitiligo: Clinical and demographic perspectives – A cross-sectional study
Authors: Vedamurthy Maya , Kumar Mathivathani , Boda Sameera
Published: April 2024

Objectives:

Vitiligo is an acquired depigmentation skin disorder caused by the progressive loss of melanocytes and melanin, characterized by white macules on the skin. This study aimed to understand a specific population’s demographic and clinical characteristic factors associated with vitiligo.

Materials and Methods:

This cross-sectional study consists of 50 patients undergoing treatment for vitiligo at the RSV Clinic, Chennai, for a period of six months. Our study included comprehensive sociodemographic, clinical, and vitiligo profile examinations. Vitiligo disease activity score and vitiligo area scoring index were assessed in all patients, and their treatment approaches were noted.

Results:

The results showed that vitiligo was most common in adolescents and young adults (66%), followed by children under 10 (18%) and adults over 50 (20%). There was a nearly equal gender distribution, with 52% females and 48% males. Education levels varied, and no specific association with vitiligo was found. The onset of symptoms ranged widely, with lips (28%) and face other than lips (24%) as common initial sites. Coexisting conditions included premature canities (10%) and psoriasis (6%). Treatment approaches varied, with 26% undergoing topical steroids and other therapies. Various triggers were identified, such as trauma (10%) and stress (6%). Clinical manifestations included leukotrichia (18%) and trichrome lesions (10%).

Conclusion:

This study confirms vitiligo’s prevalence in adolescents and young adults, emphasizing its link to autoimmune disorders. It also underscores complex triggering factors and diverse clinical manifestations among those with vitiligo, enhancing our understanding of its demographics and clinical characteristics in this population.
Prolonged Stay in ICU after Cardiac Surgery: Challenges –A Review
Authors: Nambiar Prajeesh M. , Bhan Anmol , Mehta Y.
Published: April 2024

Prolonged stay in the intensive care unit (ICU) following cardiac surgery has become a topic of increasing concern in the medical community. While advancements in surgical techniques and perioperative care have improved the outcomes of cardiac surgeries, some patients still experience extended ICU stays due to various complications and comorbidities. This review article aims to explore the reasons behind prolonged ICU stays after cardiac surgery, their impact on patient outcomes, and the strategies and innovations that healthcare providers can employ to mitigate these challenges.
Effect of Aerobic Exercise on Sleep, Depression, and Quality of Life in Postmenopausal Women
Authors: Sharma Shelly , Kalra Sheetal , Rai Richa Hirendra , Parveen Afsha , Raghav Deepak , Naswa Ruchika
Published: April 2024

Objectives:

Menopause is a normal life stage that frequently brings with it emotional and physical difficulties that affect women’s Quality of life (QoL) and interfere with their ability to sleep. The objective of this study was to examine how postmenopausal women (PMWs) responded to supervised aerobic exercise training versus unsupervised Walking in terms of sleep, QoL, and depression. In addition, the impact on body composition was also assessed as a secondary outcome measure.

Material and Methods:

Fifty PMWs (aged 45–60) were divided into two groups at random: The control group (n = 25) performed standard unsupervised Walking, and the experimental group (n = 25) performed scheduled supervised aerobic exercise training. The Pittsburgh sleep quality index (PSQI), the 36-item short-form survey, the beck depression inventory (BDI), and the body mass index (BMI) were among the evaluations used in the 6-week, 3-day program.

Results:

Remarkable advancements (P < 0.05) were noted in the aerobic training cohort. The experimental group increased total sleep duration by 37.9% and fell asleep 44.8% faster, resulting in a noteworthy 61.7% improvement in the PSQI score. BDI scores improved by 55.6%, and there was a 6.8% variation in BMI between the groups.

Conclusion:

A 6-week aerobic intervention can improve sleep quality, reduce menopausal symptoms, and enhance life quality in PMW. Furthermore, the results revealed that a regulated exercise group may offer more benefits than an unregulated one. This observation underscores the potential advantages of structured and monitored aerobic exercise program in achieving specific health and fitness goals.
Innovative and simple technique of stabilizing the lingual retainer wire before bonding
Authors: Korwar Pradnya Atish , Gheware Anjali , V. K. Ravindranath
Published: April 2024

Long-term stability of orthodontic treatment outcome is attained through retention. Fabrication and bonding of the lingually bonded retainer on the lingual tooth surface are a technique-sensitive and time-consuming procedure. Stabilizing the lingual retainer wire on the tooth surface throughout the bonding procedure is a challenging task for the operator. This article introduces a new simplified technique of stabilizing the lingual retainer wire before bonding.
La quête identitaire des peuples indigènes brésiliens : une sémiotique de transition
Authors: Pastorini Vanessa
Published: April 2024

Dans ce travail, nous proposons une réflexion sur la notion d'identité à partir de la théorie sémiotique. Pour cela, nous prenons en considération le mouvement de transition entre l’identité attribuée aux peuples indigènes brésiliens par le biais du pouvoir et l’identité spécifique qu'ils sont en train de construire eux-mêmes. À cette fin, nous analysons les jeux de vérité utilisés dans la construction des discours identitaires et stéréotypés, ainsi que ceux produits par les influenceurs indigènes dans les médias. Pour ce faire, nous nous appuyons sur les notions de contrat véridictoire ainsi que sur la notion de camouflage. Pour conclure, nous indiquons aussi la façon dont les sujets de ce groupe minoritaire ont revisité les catégories qui leur ont été assignées par l'histoire, en créant ainsi des espaces de disputes discursives.
Photographier et questionner un nouvel appariement territorial
Authors: Périneau-Lorenzo Sylvie
Published: April 2024

À la différence de la transition écologique, une transition territoriale, au départ, met à égalité les espaces, les vivants et les choses par rapport à ce qui leur arrive et la situation nouvelle – la réalité administrative d’une région qui devient autre - est muette pour le langage ou stérile pour l’imaginaire. Au contraire, le projet Vu d’ici ce n’est pas si loin s’occupe par sa démarche globale et tout particulièrement par un ouvrage photographique, d’enquêter puis de traduire en vues l’existence de cette nouvelle dimension et la sensation d’être lié à la Nouvelle-Aquitaine d’une manière ou d’une autre. À travers la médiation d’isotopies spatio-temporelles sensibles, nous affirmons que les photographies collectées puis agencées instaurent une économie interprétative. En effet, elles font circuler ces vues comme traces, repères et symbolisations en s’adressant à trois types de participants : les enquêteurs eux-mêmes, par un effet de boucle ; les sujets enquêtés, qu’ils soient présents à l’image ou reliés aux espaces, vivants et choses présentés ; et les lecteurs de l’ouvrage, néo-aquitains ou simples curieux. Ainsi, l’appréhension de ce que peut être une transition territoriale s’enrichit : l’ouvrage nous engage à nous intéresser à l’appariement territorial que crée le régime de transition et aux différentes configurations objectives, subjectives, vécues et imaginatives qu’il déploie à partir d’un « paradigme moléculaire » (Hébert 1995 : 71).
L’algorithme et l’organon sémiotique
Authors: Beyaert-Geslin Anne
Published: April 2024

Même si l’algorithme est omniprésent et semble régler nos vies, ses définitions restent souvent laconiques et plus ou moins métaphoriques. Plus que sa définition, c’est la description de son fonctionnement qui retient généralement l’attention. Il apparaît alors sous les traits d’un actant algorithmique ayant le statut de destinateur social invisible, donc inquiétant. Le mot algorithme appartient depuis longtemps au métalangage de la sémiotique qui, par vocation, concentre son attention sur le fonctionnement des discours, plus exactement sur la relation entre les termes, leur mode d’agencement, pour se demander « comment cela signifie » (Floch 1985). Intégré à son organon, le terme algorithme permet de décrire les transformations narratives et la reconfiguration des unités du récit par le discours mythique. Cet article propose d’observer l’usage du terme algorithme par la sémiotique et de caractériser cet algorithme créatif ancien relativement à l’algorithme informatique aujourd’hui entré dans le langage courant. Dans quelle mesure le terme permet-il de décrire l’organisation des connaissances ?
Melanom cutanat de membru inferior – provocări. Prezentare de caz
Authors: Mihaela Moraru , Iolanda Goga , Maria-Andreea Ilie , Dana-Lucia Stănculeanu , Adelina-Silvana Gheorghe , Elena-Adriana Dumitrescu , Daniela-Luminiţa Zob
Published: April 2024

Cutaneous malignant melanoma is the 15th most common cancer among women, and the incidence and mortality associated with malignant melanoma continue to increase. There are several histopathological subtypes: superficial spreading, nodular, lentigo maligna, acral lentiginous, desmoplastic, and amelanotic. In this case report, we present the histopathological, local and therapeutic evolution of this aggressive pathology. A young female patient was initially diagnosed with nodular cutaneous melanoma
at the lower one-third of the calf in an advanced stage, necessitating limb amputation. However, the treatment began with systemic therapy using checkpoint inhibitors as the initial therapeutic stage. Subsequently, due to resistance to this therapy and the development of an immune-related adverse reaction, targeted therapy with BRAF/MEK inhibitors was initiated, the patient presenting the positive BRAF mutation. Thus, a favorable response was achieved through the durable effects of immunotherapy and treatment with BRAF/MEK inhibitors, leading to the conversion of the lesion to a state amenable to limited resection.
Mielom multiplu cu debut atipic şi afectare renală – prezentare de caz
Authors: Andreea Calenic , Bianca Boitan , Ana Stanciu , Cristina Căpuşă
Published: April 2024

Plasma cell dyscrasias can have a heterogenous onset and, also, kidney involvement, associated with various clinical presentations. This mandates always considering plasma cell dyscrasias as a possible diagnosis when faced with a case with unusual progression. We report the case of a 44-year-old male with a sellar mass that was diagnosed first as an atypical pituitary adenoma, who later developed kidney involvement manifested as renal insufficiency and proteinuria, with a pathology report suggesting
focal and segmental glomerulosclerosis. Within a year, he was diagnosed with multiple myeloma, prompting pathological reevaluation of the sellar mass and the change of diagnosis to solitary sellar plasmacytoma.
Particularităţi morfologice ale leucemiei acute mieloide asociate mielodisplaziei (LAM-MR)
Authors: Stejara-Nicoleta Mihai , Dragoş-Claudiu Popescu , Cristina-Tatiana Enache , Badea Silvia , Mambet Cristina , Vlădăreanu Ana Maria
Published: April 2024

Representative microscopic images of bone marrow aspirate from a patient previously diagnosed with high-risk myelodysplastic neoplasm that has recently evolved into acute myeloid leukemia (AML)
Urgenţe splenice în patologia oncohematologică: ce este important de ştiut în evaluarea CT?
Authors: Lupescu Ioana G. , Anghel Cristian , Radu-Lucian Dumitru , Dumitrescu Cristina , Adrian Dijmărescu , Grasu Mugur C.
Published: April 2024

The purpose of this article is to present and illustrate the computed tomography (CT) findings of splenic emergencies – vascular and infectious – encountered in hematologic malignancies, based on a selection of cases. The CT aspects were classified in vascular – hemorrhagic and ischemic – splenic lesions and infectious (abscesses) lesions. CT evaluation plays a crucial role in the diagnosis of acute splenic lesions in patients with hematologic malignancies.
Polycythemia Vera Associated with Diffuse Large B-Cell Lymphoma: A Case Report
Authors:   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, Filali Imane Ait El , Haidouri Soukaina ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, El Maachi Nora ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, Benlachgar Naoufel ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, Maamar Mouna ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, Harmouch Hicham ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, Mezalek Zoubida Tazi ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco, Adnaoui Mohammed ,   Department of Hematology and Internal Medicine, CHU Ibn Sina, Rabat, Morocco
Published: April 2024

Diffuse Large B-cell Lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma, accounting for more than 30% of cases, particularly in developing countries. Polycythemia Vera (PV) is a chronic myeloproliferative disorder characterized by an increase in the number of red blood cells, and often leukocytes and peripheral blood platelets. PV is most commonly diagnosed in individuals around the age of 60, and slightly more common in women, the clinical course is long and can lead to thrombotic complications, which may be the first symptom of the disease. In approximately 10% of patients, PV may progress to Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). The co-occurrence of DLBCL with a JAK2V617F-positive Myeloproliferative Neoplasm (MPN) is rarely documented in the literature. Here we describe a 64-year-old patient diagnosed with both DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) and polycythemia, with a particularly short time between identification of these conditions.
Indications of Intrapartum Blood Transfusion among Sudanese Women
Authors:   Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Al Neelain University, Sudan, Suliman Awadalla Abdelwahid , Ahmed Hajar Suliman Ibrahim ,   Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Al Neelain University, Sudan, Ibrahim Abdelgadir Suliman ,   General Practitioner Christchurch Medical Centre, Ardington Rd, Northampton NN1 5LT, Abington Park Surgery, Sudan, Mandar Omer ,   Assistant Professor of Obstetrics & Gynecology, Prince Sattam bin Abdulaziz University, Saudia Arabia, M Handady Siddig Omer ,   Associated Professor of Obstetrics & Gynecology, Faculty Medicine, Al Nahda University, Ibrahim Malik Teaching Hospital, Sudan, Alawd A Wad Ali M ,   Faculty of Medicine, University of Medical Sciences and Technology, Sudan
Published: April 2024

Background: little attention has been given in the literature to the problems of intra partum blood transfusion, but many hospitals note that they make a substantial contribution to good maternal outcome. Intrapartum blood transfusion is life saving and reduce maternal mortality. Objective: The main objective of the study was to determine indications, incidence and risk factors of intra partum blood transfusion among Sudanese women. Methodology: It was a descriptive prospective cross-sectional hospital-based study conducted in Khartoum teaching hospital during period May 2012 - October 2012. An interview questionnaire was used for data collection. The data was collected by trained doctors in the labour room. Two hundred and forty (240) pregnant women received blood intra partum were included in the study after an informed consent. Data was collected by structure questionnaire. Demographic and clinical data concerning personal history, risk of blood transfusion, type of blood and preparation of were recorded Results: Total the deliveries during period of the study were 6813, and 240 of the women received a blood transfusion so the rate of blood transfusion was 4%. The mean age and parity of the women who received blood transfusions were 27.6 years, and two respectively.
Immunity, Inflammation and Disease: What the Physician Should Know
Authors:   Department of surgery, Faculty of Health Sciences, University of Buea, Cameroon, W/Africa, Weledji Elroy Patrick , Ngounou Eleanor ,   Department of Biomedical Sciences, Faculty of health Sciences, University of Buea, Cameroon, W/Africa
Published: April 2024

The immune response system contributes to the body’s defence against infection, toxic or allergenic substances and is concerned with the recognition of tumour cells. In responding to a challenge the immune system is able to distinguish the body’s own cells and components (self) via the major histocompatability complex (HLA-DR) class 1 from cells that are foreign (non-self). The abnormalities of the immune response is demonstrated in the immunodeficiency diseases (congenital and acquired), the hypersensitivity reactions that may be involved in producing autoimmune diseases and the switching-off of T cell function by cancer cells. The genetic regulations of the immune system have major implications in clinical medicine as to the understanding of autoimmune disease and the idiotypic network that militates against autoimmune response and excessive immune responses. The relationship between immune function and tumour cells is highly complex but crucial to the understanding of both tumour rejection and progression mechanisms. The improved knowledge of the immune system has expanded the role of immunotherapy and vaccine therapy in oncology. The article reviewed the essential immune mechanisms in health and disease, and the clinical implications.
Lack of Reactivation of Latent Tuberculosis despite PD-1 Immunotherapy and Chemotherapy: A Case Report and Systematic Review
Authors:   Abdominal Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, China, Yang Xiaojuan , Xian XingHong ,   Department of Pulmonary and Critical care Medicine, West China Hospital, Sichuan University, Chengdu, China, Zhu Qing ,   Abdominal Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, China, Wang Ke ,   Department of Pulmonary and Critical care Medicine, West China Hospital, Sichuan University, Chengdu, China
Published: April 2024

Background: Programmed Death 1 (PD-1) has a controversial role in the treatment of Tuberculosis (TB). Several clinical cases of TB development have been reported by administration of anti–PD-1 antibodies for patients with advanced unresectable cancers. Case presentation: In this article, we report an interesting case about a male patient with history of cured pulmonary tuberculosis and a 4-month history of repeated hemoptysis. Imaging showed one mass in the lower lobe of left lung and the other in the left upper lobe. The diagnosis of Non-Small-Ccell Lung Cancer (NSCLC) was determined by biopsy specimens in the lower lobe nodule and cured pulmonary tuberculosis determined by past medical history. He was given neoadjuvant treatment with an anti–PD-1 inhibitor and chemotherapy. He underwent surgery. Pathological examination revealed Mtb in left upper lobe nodule but previous imaging showed without reactivation and slight reduction in tubercular infection inflammation. The left lower lobe nodule was poorly differentiated carcinoma. Conclusions: Overall, the role of immune checkpoint inhibitors in patients with cancers and latent tuberculosis infection is inconclusive. Although we cannot establish whether patients with stage IIIA NSCLC and concurrent latent pulmonary tuberculosis after surgical evaluation can receive a PD-1 and chemotherapy as neoadjuvant therapy without the activation of pulmonary tuberculosis, our case endorses the need of further evaluation.
3D Printing Carbon-Carbon Composites With Multilayered Architecture for Enhanced Multifunctional Properties
Authors: Ravichandran Dharneedar , Dmochowska Anna , Sundaravadivelan Barath , Thippanna Varunkumar , de Castro Emile Motta , Patil Dhanush , Ramanathan Arunachalam , Zhu Yuxiang , Asadi Amir , Peixinho Jorge , Miquelard-Garnier Guillaume , Song Kenan
Published: April 2024

Carbon-carbon (C-C) composites are highly sought-after in aviation, automotive, and defense sectors due to their outstanding thermal and thermo-mechanical properties. These composites are highly valued for their exceptional thermal and thermo-mechanical properties, including remarkably low density and coefficient of thermal expansion, which are expected to surpass those of many alloys and other composites in the production of high-grade components. However, the current manufacturing methods for C-C composites are unable to meet market demands due to their high cost, low production speed, and labor-intensive processes, limiting their broader applications. This study presents an innovative approach by introducing a new extrusion-based 3D printing method using multiphase direct ink writing (MDIW) for C-C composite fabrication. The primary matrix utilized is a phenolformaldehyde thermosetting resin, reinforced with silicon carbide (SiC) and graphite nanopowder (Gnp), focusing on achieving simple, scalable, and environmentally sustainable production of green parts with enhanced polymer matrix. This is followed by an inert carbonization process to obtain the final C-C composites. The research emphasizes the careful optimization of curing and rheological properties, including the use of suitable viscosity modifiers like carbon black (CB). Furthermore, the MDIW process demonstrates its capability to pattern dual nanoparticles within the composite structure in a well-ordered manner, leading to improved overall performance. Thermo-mechanical and thermo-electrical properties were thoroughly tested, showcasing the multifunctionality of the composite for diverse applications, from high-value industries like aerospace to broader uses such as heatsinks and electronic packaging.
The structural and functional basis of GenB2 isomerase activity from gentamicin biosynthesis
Authors: de Oliveira Gabriel , Bury Priscila , Huang Fanglu , Li Yuan , Araújo Natália , Zhou Jiahai , Sun Yuhui , Leeper Finian , Leadlay Peter , Dias Marcio
Published: April 2024

Aminoglycosides are important antibiotics used to treat severe infections caused mainly by gram-negative bacteria. Gentamicin is an aminoglycoside, and despite its toxicity, is clinically used to treat several pulmonary and urinary infections. The commercial form of gentamicin is a mixture of five compounds with minor differences in the methylation of one of their aminosugars. In the case of two compounds, gentamicin C2 and C2a, the only difference is the stereochemistry of the methyl group attached to C-6’. GenB2 is the enzyme responsible for this epimerization and it is one of the four PLP-dependent enzymes encoded by the gentamicin biosynthetic gene cluster (BGC). Herein, we have determined the structure of GenB2 in its holo form in complex with PMP and also in the ternary complex with gentamicin X2 and G418, two substrate analogs. Based on the structural analysis, we were able to identify the structural basis for the catalytic mechanism of this enzyme, which was also studied by site-directed mutagenesis. Unprecedently, GenB2 is a PLP-dependent enzyme from fold I, which is able to catalyze an epimerization, but with a distinct mechanism from fold III PLP-dependent epimerases, using a cysteine residue near the N-terminus. The substitution of this cysteine residue for serine or alanine completely abolished the epimerase function of the enzyme confirming its involvement. This study not only contributes to the understanding of the enzymology of gentamicin biosynthesis but also provides valuable details for exploring the enzymatic production of new aminoglycoside derivatives.
Conformational Isomerization of the Fe(III)-OH Species Enables Selective Halogenation in Non-Heme Iron Halogenase BesD and Hydroxylase-Evolved Halogenase
Authors: Zhang Jinyan , Li Yifan , Yuan Wenli , Zhang Xuan , Si Yubing , Wang Binju
Published: April 2024

Non-heme iron(II)/2-oxoglutarate (Fe/2OG)-dependent enzymes catalyze a large number of C-H bond activation and functionalization. Especially, non-heme iron halogenases catalyze the selective C-H halogenation, representing an attractive strategy for the biosynthesis of halogenated compounds. Despite extensive endeavors from experiments and computations, how non-heme iron halogenases dictate the reaction toward the thermodynamically unfavored halogenation is still elusive. Here, we have investigated the chlorination versus hydroxylation selectivity in both halogenase BesD and hydroxylase-evolved halogenase Chi-14, using extensive MD simulations and QM/MM calculations. In BesD, our calculations have shown that 2OG-assisted O2 activation affords the axial Fe(IV)-oxo species that is responsible for the substrate C-H activation. To facilitate the following Cl-rebound reaction, the nascent axial Fe(III)-OH species has to undergo the conformational isomerization to the equatorial one. This can remove the steric effects between the axial Fe(III)-OH and the substrate radical, thereby facilitating the migration of substrate radical toward Cl-ligand during the Cl-rebound. Notably, the second-sphere residue Asn (Asn219 in BesD or Asn225 in Chi-14) can form persistent hydrogen bond interactions with succinate, which is vital to maintain the unsaturated five-coordination shell of Fe, thereby facilitating the conformational flip of Fe(III)-OH from the axial orientation to the equatorial one. Our findings agree with the available experimental information, highlighting the key role of the coordination dynamics of iron in dictating the catalysis of non-heme enzymes.
HinZip, a designed frankenprotein that combines Hin recombinase and FosW, mimics the structure and DNA-binding function of the HD-Zip plant transcription factor family
Authors: Akel Raneem , Edaibis Rama , Shin Jumi
Published: April 2024

Small bespoke proteins that bind a desired DNA sequence in a cell's genome could be a powerful tool in various applications. Examples include using genetically encoded tools to control gene circuits in synthetic biology, or serve as a protein drug that inhibits a disease network impacting human health. We designed HinZip to bind a specific target comprising at least 24 base pairs with high affinity and DNA sequence specificity, because a larger DNA sequence is likely to be unique in a genome, thereby minimizing off-target effects. We took inspiration from the HD-Zip, a transcription factor family only found in plants. No high-resolution structures exist for HD-Zip: genome-wide analyses indicate that they use a homeodomain to bind DNA and leucine zipper for dimerization. HinZip is a fusion of the Hin recombinase DNA-binding domain and FosW leucine zipper. HinZip binds cooperatively as a dimer to DNA targets comprising two 12 base-pair hixC half-sites. Using bacterial one-hybrid and quantitative electrophoretic mobility shift assays, we tested spacings of 0-9 base pairs between half-sites to optimize the orientation and space parameters that FosW needs for coiled-coil dimerization. HinZip binds cooperatively to a 29 base-pair inverted hixC palindrome with Kd 17 nM and no binding to nonspecific DNA up to 2 µM protein. Hin—which lacks ability to dimerize—was previously shown to bind hixC with Kd 34 nM, showing similar binding to half- or full-sites and no cooperativity. HinZip/LA, where the Leu residues responsible for dimerization were replaced with Ala, showed virtually no benefit from cooperative binding at any full-site, and bound first as a monomer, and then as two monomers. Circular dichroism and dynamic light scattering indicate that only HinZip is capable of forming a coiled-coil dimer. HinZip demonstrates that even in the absence of guidance from structural information, small frankenproteins designed from cut-and-paste of unrelated protein modules can specifically target long DNA sequences with broad applications toward orthogonally controlling gene networks in a wide variety of organisms.