bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation taktgesteuerter Modelle von Push- und Pull-Prozessen in der Logistik
Authors: Haag Stefan , Simon Carlo , Zakfeld Lara
Published: October 2022

Ein Wechsel von einer Push- zu einer Pull-Strategie stellt einen erheblichen Eingriff in die betriebliche Logistik dar und hat Auswirkungen auf Beschaffungsstrategien, die Ausgestaltung von Abläufen sowie die bewerteten, internen Lagerbestände. Dieser Beitrag nutzt Petri-Netz-Modelle zur taktgesteuerten Simulation solch unterschiedlicher Prozessszenarien als Managementwerkzeug für deren Bewertung. Eine taktgesteuerte Simulation erlaubt dabei Bestandsveränderungen in Zeitraffer zu beobachten, Engpässe zu identifizieren und die sich vor diesen aufbauenden Lagerbestände zu bewerten.Als Grundlage für die Modellierung und Simulation solch anspruchsvoller Szenarien wurde ein neuartiges, webbasiertes Petri-Netz-Modellierungs- und Simulationswerkzeug namens Process-Simulation.Center (P-S.C) entwickelt. Dieses unterstützt u.a. höhere Petri-Netze, in denen Marken attributiert sind. Erst dies ermöglicht ein Denken über und ein Ausprobieren von Techniken, wie sich solche Szenarien modellhaft umsetzen lassen. Exemplarisch wurde hierfür ein Lernlabor für Logistik realisiert, um die persönlichen Beobachtungen von Studierenden zeitlich, mengenmäßig und wertmäßig zu skalieren und um die unterschiedlichen Szenarien bewerten zu lernen.Im Folgenden wird zunächst der Laboraufbau als Beispielszenario für simulationsgestützte Managemententscheidungen beschrieben. Nachdem dann die neuartigen Funktionen des P-S.C vorgestellt werden, wird hierauf aufbauend das Vorgehen beschrieben, um Modelle für Push- und Pull-Strategien inkl. in den Petri-Netzen selbst integrierter Dashboards zu erklären. Abschließend wird die taktgesteuerte Simulation einer weiteren Modellierungstechnik, der ereignisgesteuerten Simulation, gegenübergestellt.
Beispiele für problematische KI-Anwendungen
Authors: Bläsius Karl Hans
Published: October 2022

In diesem Artikel werden drei Beispiele für problematische Anwendungen der Künstlichen Intelligenz (KI) vorgestellt. Bei diesen Beispielen "Ableiten von persönlichen Eigenschaften", "autonome Waffensysteme" und "computerstützte Frühwarn- und Entscheidungssysteme" geht es um potenziell erhebliche Auswirkungen für die Menschheit. Der Autor ist jedoch davon überzeugt, dass die meisten KI-Anwendungen positiv für die Menschen sind. Um einerseits nicht nur einen negativen Blick auf KI-Entwicklungen zu werfen und um andererseits Hinweise auf Erkennungskriterien zu liefern, die zur Beurteilung von problematischen Anwendungen hilfreich sein können, werden auch drei Anwendun-gen mit eigener Beteiligung vorgestellt. Hierbei wird auch auf die Aspekte Vagheit und Unsicherheit eingegangen, die auch bei den problematischen KI-Anwendungen relevant sind.
CAPACITY LOSS ESTIMATION FOR LI-ION BATTERIES BASED ON A SEMI-EMPIRICAL MODEL
Authors: Rabah Mohammed , Immonen Eero , Shahsavari Sajad , Haghbayan Mohammad-Hashem , Murashko Kirill , Immonen Paula
Published: October 2022

Understanding battery capacity degradation is instrumental for designing modern electric vehicles. In this paper, a Semi-Empirical Model for predicting the CapacityLoss of Lithium-ion batteries during Cycling and Calendar Aging is developed. In order to predict the Capacity Loss with a high accuracy, battery operation datafrom different test conditions and different Lithium-ion batteries chemistries were obtained from literature for parameter optimization (fitting). The obtained modelswere then compared to experimental data for validation. Our results show that the average error between the estimated Capacity Loss and measured Capacity Loss isless than 1.5% during Cycling Aging, and less than 2% during Calendar Aging. An electric mining dumper, with simulated duty cycle data, is considered as an applicationÂ example.
Magnetostriction Generator as Acoustic Wave Generator for Underwater Applications
Authors: Rustamaji Rustamaji , Sawitri Kania , Ahdan Mustafidz
Published: October 2022

At this time the research related to the effect of magnetostriction for underwater applications is still limited. Acoustic or sound waves are more easily propagated underwater than electromagnetic waves or light. An acoustic wave or sound can be generated by utilizing the magnetostriction effect, where this effect occurs when a rod of ferromagnetic material such as iron or nickel is magnetized and interacts with another magnetic field, resulting in vibration of the metal rod. This research aims to design and realize a magnetostriction generator as an acoustic wave generator at a frequency of 1 to 10 kHz for underwater applications, consisting of: a tuned LC oscillator circuit, and a ferromagnetic metal rod which is magnetized using a dc voltage. The results of measurements and testing of the magnetostriction generator show: (1) if it is equipped with a membrane, can work to emit an acoustic wave or sound at a frequency of ± 8.62 kHz in the air up to a distance of 15 cm without distortion with an average amplitude decrease of ± 0.648 dB for each the distance increased by 1 cm, and (2) if equipped with a membrane and enclosed in a waterproof casing, capable of transmitting the acoustic waves at a frequency of ± 8.31 kHz underwater up to a distance of 7 cm without distortion with an average amplitude decrease of ± 4.217 dB for each the distance up 1 cm. Overall the magnetostriction generator designed can work to generate and transmit the acoustic waves or sound underwater, as expected.
UPAYA PEREMPUAN SINGLE PARENT PADA SEKTOR INFORMAL DALAM PEMENUHAN KEBUTUHAN KELUARGA
Authors: Simanullang Lusi Marlina , Elvawati Elvawati , Isnaini Isnaini
Published: October 2022

This research is motivated by the high number of single-parent women, 40% of whom work in the informal sector, and the income and expenses of single-parent women are not balanced, thus making women constrained in meeting family needs. This study aims to describe and analyze the efforts of single-parent women in the informal sector in meeting family needs in Nagari Tanjung Beringin, Lubuk Attitude District, and Pasaman Regency. The approach used in this study is a descriptive qualitative approach. Observation, interviews, and documentation studies carried out data collection techniques. The unit of analysis in this study is the individual. The Miles and Huberman model uses the data analysis technique, namely data collection, data reduction, data presentation, and concluding. The conclusion from the results of this study is that single-parent women who work in the informal sector to meet the needs of their families make efforts to meet the requirements; namely, single-parent women have side jobs. In contrast, they use family relationships, collect agricultural products such as vegetables, chocolate, corn, and areca nut, borrow funds from formal and non-formal financial institutions, and other single-parent women make savings to meet their needs families.
PELESTARIAN NILAI KEARIFAN LOKAL MELALUI KESENIAN REOG KENDANG DI TULUNGAGUNG
Authors: Nurmaning Bina Andari
Published: October 2022

All regions in Indonesia almost own the value of local wisdom, and it's just that, in reality, it is infrequent to find local knowledge that is empowered in everyday life as a direct result of the era of globalization. Such a significant relationship between culture and society makes culture essential for humans, where people cannot leave the culture they already have. All regions almost own the value of local wisdom, and it's just that, in reality, it is scarce to find local knowledge that is empowered in everyday life as a direct result of the era of globalization. Variety of local wisdom, one of which is the art of reog kendang. The research approach is qualitative research. Observation, interviews, and documentation were carried out in the data collection in this study. Data analysis was carried out, namely: Data reduction (data reduction), Data presentation (data display), and Data verification (conclusion drawing/verification). The result of the research is that the actions of students practicing dancing in Reog Kendang for the preservation of local wisdom values are carried out by: They practice dancing diligently, They discuss how to be able to follow dance movements quickly, They play and joke with friends, They get bored quickly if they can't track activities that are considered problematic. In the show, six dancers perform Reog Kendang in groups, each carrying a drum or hotdog. Reog Kendang is often displayed in significant events held in Tulungagung district, East Java. In addition, this dance is also usually performed at various cultural festivals, both at the regional and national levels. Along with the development of this dance, the era began to see many changes, with the addition of various variations in terms of movement, costumes, musical accompaniment, or presentation.
FENOMENA MENIKAH MUDA DIKALANGAN REMAJA PEREMPUAN DI KELURAHAN PIPITAN
Authors: Suryani Danik , Kudus Wahid Abdul
Published: October 2022

Marriage is an essential thing in the cycle of human life. Nowadays, the phenomenon of getting married at a young age is widespread in society. One of the reasons for marrying young is to avoid promiscuity that violates religious and social norms, besides reducing the burden on parents. Usually, couples who marry young generally have a high tolerance for change and mature more quickly than those involved in this study using a descriptive qualitative research method. The data collection techniques in this study were observation, interviews, and literature study. This research article aims to determine the phenomenon of young marriage among adolescent girls in Pipitan Village, Walantaka District, Serang City, Banten Province. The results of the research obtained in this article are (1) the driving factors of young marriage that occur among adolescent girls in Pipitan Village. (2) How does this young woman in Pipitan Village live her life as a wife. (3) Strategies used in overcoming problems related to their role as a young married couple. (4) What are the effects on young women in Pipitan Village who marry young.
IMPLEMENTASI KEBIJAKAN GERAKAN LITERASI DI SEKOLAH DASAR
Authors: Rizqiyah Nayla , Rendiyawati Rindi , Agustin Serlina
Published: October 2022

The low interest in reading students in Indonesia is a concern for the government. The Ministry of Education and Culture continues to provide innovations to increase reading interest, especially for students. In the policy of the School Literacy Movement, Elementary School is one of the main implementing parts of the implementation as a provider of facilities, guidance, and infrastructure for students. Indeed, the School Literacy Movement in Elementary Schools has three stages or processes, namely (1) habituation; (2) Development; and (3) learning. Implementation carried out at each school will certainly experience different stages and programs implemented. Factors that influence this are the readiness of the school's physical capacity, the readiness of school residents, and the readiness of other support systems (Faizah et al., 2016). This research uses a qualitative approach with a literature study method. The activity in this research process is to collect research data that has been done regarding the implementation of the School Literacy Movement in Elementary Schools. The sources used for this research are the results of the analysis of books and journals related to the title of research on the School Literacy Movement. The data analysis technique used in this research is the reduction technique.
PENERAPAN E-LEARNING DALAM INOVASI PENDIDIKAN UNTUK MENINGKATKAN KEMAMPUAN LITERASI DIGITAL SISWA
Authors: Arfadila Arfadila , Aulia Erlinda Risa Nur , Nugraha Reska Widyaksana , Humaeroh Siti
Published: October 2022

Our research aims to be able to analyze e-learning learning systems in an effort to improve digital literacy skills for students in the 21st century. Given that technology has penetrated into many human activities, including teaching and learning activities, it needs to be used optimally so that learning is not only a process of knowledge transfer but also as an increase in literacy skills for students. This research uses literature study method. Where will be obtained a conclusion from the findings of previous research that is focused on certain data sources. The results show that the application of e-learning is related to digital literacy. E-learning can make students become independent in finding information which can also train students' critical thinking patterns towards information that is obtained or received. The background for choosing this research is because we see from the phenomena that occur around us that today's technology is sometimes not optimized, therefore it is necessary to integrate basic things such as from the world of education. Where with education there will be a learning process and training skills which are certainly useful in the 21st century. The conclusion from our research is that the application of e-learning has a good impact on increasing students' digital literacy. Moreover, currently the application of e-learning has not been fully implemented in Indonesia, so this has become an innovation that needs to be promoted in all schools in every educational unit. Because as students adapt to the 21st century, we are required to have good literacy such as digital literacy as a way of receiving information.
NILAI-NILAI PANCASILA SEBAGAI PANDANGAN HIDUP DAN PEMBENTUK KARAKTER BANGSA
Authors: Putri Annisa Laela , Dewi Dinie Anggraeni
Published: October 2022

The purpose of this study is to find out that Pancasila values are a way of life for the Indonesian people in living life as citizens and also aim to explain that Pancasila values if we practice them will shape the personality and character needed to become good citizens. beneficial not only for himself but for the Indonesian nation. The method used in this research is a literature study in which the author examines the literature, notes, and reports related to the problems to be solved. The success of a nation in achieving its goals is proven by the quality of its human resources. Moreover, it is stated that "a strong nation can be seen from the quality or character of its people". The values contained in Pancasila are the original behavior and character of the former Indonesian nation. Making Pancasila a way of life for the Indonesian people to take actions according to Pancasila values in their daily lives. The experience of Pancasila in everyday life must be respected in order to create an orderly nation's life.
DAMPAK PEMBERIAN LABEL MISKIN KEPADA KELUARGA PENERIMA BANTUAN PKH DI JORONG TANJUNG DURIAN KEC. SANGIR JUJUAN KAB. SOLOK SELATAN
Authors: Hidayat M. Rahmat , Rahmadani Sri , Erningsih Erningsih
Published: October 2022

This research examines about The Impact Of Labeling Poor On PKH Recipient Families In Jorong Tanjung Durian, Sangir Jujuan District South Solok Regency. This study aims to describe the impact of labeling poor in Jorong Tanjung Durian Nagari Padang Limau Sundai, South Solok Regency. The approach used in this study is a descriptive qualitative approach. Data collection techniques were carried out by observation, interviews, and documentation studies. The unit of analysis in this study is PKH recipient family. The data analysis technique used is the Miles and Huberman model, namely data collection, data reduction, data presentation, and drawing conclusions. The results of this study can be concluded that the impact of labeling poor on families receiving PKH assistance in Jorong Tanjung Durian, Sangir Jujuan District, South Solok Regency is (1). PKH recipient families feel awkward in society. (2). PKH recipient families become a byword in society. (3). PKH recipient families are belittled in society. (4).  Have the opportunity for their children to receive scholarships at school. (5). Opportunity to receive assistance again in the future.
ANALISIS FAKTOR PENYEBAB ANAK PUTUS SEKOLAH JENJANG SEKOLAH MENENGAH PERTAMA DI DESA MAJU KARYA KECAMATAN PARINDU KABUPATEN SANGGAU
Authors: Pandu Kristian Trikurnianto , Aminuyati Aminuyati , Atmaja Thomy Sastra
Published: October 2022

This study describes the causes of students at the junior high school level in Desa Maju Karya, Kecamatan Parindu of Kabupaten Sanggau, drop out of school. This study identifies the factors causing children in the studied area to drop out of school. This study analyzes the factors that cause children to drop out of school in Maju Karya Village, Parindu District, Sanggau Regency. Qualitative approach with a descriptive method was employed in this study. The research data was obtained using observation, interviews, and documentation. Data reduction, data display, and drawing conclusions were employed to analyze the data. The data validity was verified using triangulation technique. Based on the analysis, the researchers found two factors causing children to drop out of school, namely internal factors, which include a sense of laziness and lack of interest in learning; and external factors which include the low level of parental education, lack of parental attention, broken families, weak economy, and peers that have a negative influence.
EFEKTIVITAS PENERAPAN MEDIA PEMBELAJARAN POWTOON TERHADAP HASIL BELAJAR PESERTA DIDIK PADA MATA PELAJARAN IPS
Authors: Scolastika Gracia Efra , Barella Yusawinur , Aminuyati Aminuyati , Okianna Okianna , Atmaja Thomy Sastra
Published: October 2022

This study aimed to determine the effectiveness of the Powtoon application on the learning outcomes of class VIII social studies. This study used a quantitative approach in the form of a quasi-experimental study. The sample of this study comprises 8th-grade B and 8th-grade C students, up to 22 students per class. The data collection techniques used were assessment techniques and documentary study, as well as data collection tools in the form of post-tests and research documents. The results showed that the mean scores from the post-test for the experimental group was 73.81, and the control class was 59.54, with a difference of 14.27. As a result, there are significant differences in learning outcomes. In the normality test, the significance value of the experimental group was 168>0.05, while the significance value of the control group was 143>0.05. Therefore, the data is in a normal distribution. In the hypothesis test, the sig. value (2-tailed) is 0.000<0.05, with an effect size of 1.07>0.08, which is in the high category. The results showed that the Powtoon application is effective and efficient for eighth-grade social studies learning outcomes.
FAKTOR PENYEBAB KELUARGA MAMPU MENERIMA BANTUAN PROGRAM KELUARGA HARAPAN (PKH) DI NAGARI ALAHAN NAN TIGOKECAMATAN ASAM JUJUHAN KABUPATEN DHARMASRAYA
Authors: Parida Parida , Yuhelna Yuhelna , Erningsih Erningsih
Published: October 2022

PKH assistance is one form of assistance aimed at underprivileged communities to be able to help improve their lives, but a lot of this assistance that is obtained is not in accordance with its target. Where people who can afford it also get help. This is of course not in accordance with the applicable provisions relating to the terms of the beneficiary. The purpose of this study was to analyze the factors that cause families to be able to receive the Family Hope Program (PKH) assistance from Nagari Alahan Nan Tigo, Asam Jujuhan District, Dharmasraya Regency. The theory used in this study is the theory of functional structure proposed by Robert K. Merton. The research was conducted in Nagari Alahan Nan Tigo, Asam Jujuhan District, Dharmasraya Regency. This study used qualitative research methods with descriptive research type. Withdrawal of informants is done by purposive sampling technique, with the informants are well-off families who receive assistance. The data collection method in this study begins with observation, interviews, and document studies. Data analysis was carried out in several stages, namely, data collection, data reduction, data presentation and drawing conclusions. The results showed that there were several factors that caused capable families to also receive PKH assistance (Program Keluarga Harapan) in Nagari Alahan Nan Tigo, Asam Jujuhan District, Dharmasraya Regency, including 1) Relationship between PKH recipients and data collection officers 2) lack of understanding of PKH recipients on the use of aid.
Facial transsexualizing procedures in people with gender dysphoria: literature review
Authors: Bueno Marcus Vinícius , Iida Letycia Mary , Nápole Rita de Cássia d'Ottaviano , Varotto Bruna Luiza Roim , Antequera Reynaldo
Published: October 2022

INTRODUCTION: Transsexuals are individuals who experience discomfort or anguish caused by the discrepancy between their gender identity and their assigned sex at birth, so they intensely experience the need to experience the opposite gender. The main purpose of facial masculinization and feminization is to provide the transsexual individual with a face that matches their real gender and make them accept, recognize and identify themselves by looking in the mirror, without harm or discomfort. OBJECTIVE: To carry out a review of the literature on facial transsexualization procedures to which transsexual men and women are submitted. METHODOLOGY: A literature review was carried out, highlighting the use of databases: VHL, Google Scholar, LILACS, PubMed, SciELO and Web of Science. Articles in Portuguese and English were used as selection criteria based on the descriptors from the MeSH (Medical Subject Headings) and DeCS (Descriptors in Health Sciences): transsexualism OR sex reassignment procedures OR gender identity AND feminization OR masculinization. RESULTS AND CONCLUSION: 25 studies were included to compose this review. Facial transsexualizing procedures promote confirmation and reduction of gender incongruity in transsexual individuals. There is a great scarcity of studies with this group of patients resulting from social transphobia, therefore, it is necessary to promote the awareness and training of all health professionals with the aim of reducing stigma and prejudice through information and the creation of protocols. services that understand the needs of transgender women and men.
Dual NHC/Photoredox Catalytic Synthesis of 1,4-Diketones Using an MR-TADF Photocatalyst (DiKTa)
Authors: Prentice Callum , Morrison James , Zysman-Colman Eli , Smith Andrew
Published: October 2022

The use of the recently reported organic multi-resonant thermally activated delayed fluorescence (MR-TADF) photocatalyst DiKTa allows for the modular synthesis of 1,4-diketones under mild and metal-free conditions. The reaction proceeds via a three-component relay process in the presence of an N-heterocyclic carbene (NHC) organocatalyst.
A Decacationic Ferrocene-Based Metallostar
Authors: Rupf Susanne Margot , Moshtaha Amina Leoni , Malischewski Moritz
Published: October 2022

Decacationic metallostars have been prepared by the reaction of permercurated ferrocene FeC10(HgO2CCF3)10 with superacidic (C5F5NH)(SbF6) (pKa = −11 estimated in H2O) in multigram scale. In the resulting compound, [FeC10Hg10(NC5F5)n][SbF6]10, the labile pentafluoropyridine ligands are readily displaced by acetonitrile (MeCN) or tetrahydrothiophene (THT). In the X-ray structure of [FeC10Hg10(THT)10][SbF6]10 ‧ 24 MeCN no cation-anion contacts between mercury and fluorine were observed. Moreover, cyclic voltammetry measurements of [FeC10(Hg(MeCN))10]10+ and [FeC10(Hg(THT))10]10+ revealed a (quasi)reversible one-electron oxidation of Fe(II) to Fe(III). From the reaction of [FeC10(Hg(MeCN))10]10+ with MoF6 as oxidant the ferrocenium cation [FeC10(Hg(MeCN))10]11+ was obtained and characterized via single crystal XRD. These electrophilic metallostars are promising potential building blocks for the synthesis of dendritic architectures containing a robust, tenfold functionalized ferrocene core.
ZINC-22 - A Free Multi-Billion-Scale Database of Tangible Compounds for Ligand Discovery
Authors: Tingle Benjamin , Tang Khanh , Castanon Jose , Gutierrez John , Khurelbaatar Munkhzul , Dandarchuluun Chinzorig , Moroz Yurii , Irwin John
Published: October 2022

Purchasable chemical space has grown rapidly into the tens of billions of molecules providing unprecedented opportunities for ligand discovery, but also straining the tools that might exploit these molecules at scale. We have therefore developed ZINC-22, a database of commercially accessible small molecules derived from multi-billion-scale make-on-demand libraries. The new database and tools enable analog searching in this vast new space via a facile GUI, CartBlanche, drawing on similarity methods that scale sub-linearly in the number of molecules. The new library also uses data organization methods enabling rapid lookup of molecules and their physical properties, including conformations, partial atomic charges, cLogP values, and solvation energies, all crucial for molecule docking, which had become slow with older database organizations in previous versions of ZINC. As the libraries have continued to grow, we have been interested if molecular diversity has suffered, for instance, because certain scaffolds have come to dominate via easy analoging. This has not occurred thus far, and chemical diversity continues to grow with database size, with a log increase in Bemis-Murcko scaffolds for every two logs increase in database size. Most new scaffolds come from compounds with the highest heavy atom count. Finally, we consider the implications for databases like ZINC as the libraries grow towards and beyond the trillion-molecule range. ZINC is freely available to everyone and may be accessed at cartblanche22.docking.org, via Globus, and in the Amazon AWS and Oracle OCI clouds.
Mechanistic Investigations into the Selective Reduction of Oxygen by a MCO T3 site-inspired Copper Complex
Authors: Langevelde Phebe H. , Kounalis Errikos , Killian Lars , Monkcom Emily , Broere Daniel L. J. , Hetterscheid Dennis G. H.
Published: October 2022

Understanding how multicopper oxidases (MCOs) efficiently and selectively reduce oxygen in the trinuclear copper cluster (TNC) is of great importance. Previously it was reported that when the T2-site is removed from the TNC, all O2 binding activity at the dinuclear T3-site is lost. Computational studies attribute this loss of activity to the flexibility of the protein active site, where the T3-copper centers move apart to minimize electrostatic repulsions. To address the question if and how a more constrained T3-site will catalyze the reduction of oxygen, we herein report a mechanistic investigation into the oxygen reduction reaction (ORR) activity of the dinuclear copper complex [Cu2L(μ-OH)]3+ (L=2,7-bis[bis(2-pyridylmethyl)aminomethyl]-1,8-naphthyridine). This T3-inspired complex confines the Cu centers in a rigid scaffold in close proximity instead of the flexible scaffold found in the protein active site and we demonstrate that under these constraints the dinuclear copper site displays ORR activity. Compared to the ORR mechanism of MCOs, we show that electrochemical reduction of [Cu2L(μ-OH)]3+ follows a similar pathway as the reduction of the resting enzyme due to the presence of the Cu-OH-Cu motif. By identification of key intermediates along the catalytic cycle of [Cu2L(μ-OH)]3+ we provide for the first time evidence that metal-metal cooperativity takes place during electrocatalysis of the ORR by a copper-based catalyst, which is achieved by the ability of the rigid ligand framework to bind two copper atoms in close proximity. Electrochemical studies show that the mechanisms of the ORR and hydrogen peroxide reduction reaction (HPRR) found for [Cu2L(μ-OH)]3+ are different from the ones found for analogous mononuclear copper catalysts. In addition, the metal-metal cooperativity results in an improved selectivity for the four-electron ORR of more than 70%. This selectivity is achieved by better stabilization of reaction intermediates between both copper centers, which is also essential for the ORR mechanism observed in MCOs. Overall, the mechanism of the [Cu2L(μ-OH)]3+-catalyzed ORR in this work gives insight into the ORR activity of a T3-site and contributes to understanding of how the ORR activity and selectivity are established in MCOs.
Simplified Synthesis of Air-stable Copper-complexed Josiphos Ligand via Ugi’s Amine: Complete Preparation and Analysis from Ferrocene
Authors: Johnson Jeffrey , Murphy Emma
Published: October 2022

Ligands containing ferrocene backbones often feature both planar chirality and asymmetric centers, making them attractive options for asymmetric catalysis. Ugi’s amine is a ubiquitous ferrocene-based chiral building block that can be functionalized to form a variety of tunable Josiphos ligands; however; few sources lay out the route from start to finish. Starting from ferrocene, we have compiled a synthetic route to an air- and moisture-stable copper(I)-Josiphos complex via enantiopure Ugi’s amine, providing a one-stop shop for the synthesis of a wide range of Josiphos ligands.
Spin labelling via metabolic glycoengineering for studying post-translational protein modification by electron paramagnetic resonance spectroscopy
Authors: Rubailo Anna , Wittmann Valentin , Drescher Malte
Published: October 2022

Post-translational modifications are involved in many cellular processes. The addition of O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous post-translational modification essential for regulatory processes in mammalian cells. Here, we demonstrate specific spin labelling of post-translational modifications, namely glycosylation modifications, via metabolic glycoengineering and subsequent copper-catalyzed azide-alkyne cycloaddition. Electron paramagnetic resonance spectroscopy and subsequent quantitative spectral simulations allow for detection of the labelled post-translational modifications and allows to monitor the levels of O-GlcNAcylation in presence of different and inhibitors relevant for metabolic glycoengineering.
Self-Driving Laboratories: A Paradigm Shift in Nanomedicine Development
Authors: Hickman Riley , Bannigan Pauric , Bao Zeqing , Aspuru-Guzik Alán , Allen Christine
Published: October 2022

Nanomedicines have transformed promising therapeutic agents into clinically approved medicines with optimal safety and efficacy profiles. This is exemplified by the mRNA vaccines against COVID-19, which were made possible by lipid nanoparticle technology. Despite the success of nanomedicines to date, their design remains far from trivial in part due to the complexity associated with their preclinical development. Herein we propose a nanomedicine materials acceleration platform (NanoMAP) to streamline the preclinical development of these formulations. NanoMAP combines high-throughput experimentation with state-of-the-art advances in artificial intelligence (including active learning and few-shot learning) as well as a web-based application for data sharing. The deployment of NanoMAP requires interdisciplinary collaboration between leading figures in drug delivery and artificial intelligence to enable this data-driven design approach. The proposed approach will not only expedite the development of next generation nanomedicines, but also encourage participation of the pharmaceutical science community in a large data curation initiative.
A Unified System for Molecular Property Predictions: Oloren ChemEngine and its Applications
Authors: Huang David , Chowdhuri Sauhaarda (Raunak) , Li Andrew , Li Alex , Agrawal Ayush , Gano Kameron , Zhu Andy
Published: October 2022

Molecular property predictors form the core of any AI-enabled drug discovery strategy. In recent years, there has been significant research in this area, resulting in the development of powerful predictors and representations. However, these diverse predictors have different software interfaces, dependencies, and levels of documentation. Due to lack of a unified API for molecular property prediction, an AI-enabled drug discovery endeavor often necessitates a tangled web of scripts, notebooks, and configuration. This makes it is needlessly difficult to share, distribute, and manage predictors, to ensemble predictors together, and to provide universal AI explainability tools. To this end, we present Oloren ChemEngine (OCE), an open-source Python library with a unified API for molecular property predictors with simplified model management and reproducibility. Using OCE, we create models which achieve superior performance on ADME/Tox prediction tasks by ensembling and integrating many different molecular property prediction methods. We include model-agnostic uncertainty quantification using calibrated confidence intervals and probabilities as well as interpretability using counterfactual methods.
SISTEMA DE MONITOREO DEL PROCESO DE LAVADO DE MANOS EN PERSONAL DE SALUD PARA EL INGRESO A ÁREAS CLÍNICAS BAJO EL PARADIGMA DE INTERNET DE LAS COSAS (IoT)
Authors: Quiroga Torres Daniel Alejandro , Vargas Blanco Juan Camilo , Aya Parra Pedro Antonio , Sarmiento Rojas Jefferson
Published: October 2022

En la sociedad actual una de las principales vías de transmisión de agentes patógenos, gérmenes y bacterias son las manos, provocando infecciones e inconvenientes de gran envergadura, especialmente en el sector de la salud durante la atención sanitaria. Esta transmisión de infecciones genera afecciones más graves en los pacientes, creando como consecuencia estancias más prolongadas en los centros de salud, a su vez menor disponibilidad de atención de estos. En el mundo, al menos uno de cada cuatro pacientes en servicios de cuidados intensivos contraerá una infección durante su estancia en el hospital. En países en vía de desarrollo, como Colombia, esta proporción puede llegar a duplicarse. Por tal motivo es necesario generar dispositivos que permitan el monitoreo del lavado de manos y de esta manera disminuir la probabilidad de contaminación cruzada. Por tal motivo, el objetivo de la investigación fue desarrollar un sistema de monitoreo del lavado de manos en personal de la salud por medio del paradigma de Internet de las cosas (IoT). Para ello, se diseñó un sistema bajo de IoT que permita el monitoreo del lavado de manos en personal de la salud en áreas clínicas. Se diseñaron dos estaciones de monitoreo una se encontraba en el lugar donde el personal de la salud realiza el proceso de higienización y la otra se encontraba en el ingreso del área clínica. Cada vez que el personal de salud realizaba el lavado de manos o ingresaba al área clínica, debía pasar una etiqueta RFID por las estaciones. Se realizó la validación de las estaciones por medio de 100 pruebas de lectura en cada una de ellas. En la estación 1 se encontró un 95% de lecturas efectivas, mientras que en la estación 2 el valor fue del 90%. Por otra parte, se realizaron 50 pruebas para verificar el monitoreo del lavado de manos obteniendo un error menor al 12%. El sistema de monitoreo implementado permitió realizar el seguimiento del lavado de manos en personal de la salud por medio de tecnología RFID y el paradigma de IoT.
DISEÑO INDUSTRIAL DEL PROCESO DE FABRICACIÓN DE MADERA AGLOMERADA CON BASE EN LOS RESIDUOS DE LA PRODUCCIÓN DE CAFÉ EN EL MUNICIPIO DE CAJIBÍO, CAUCA
Authors: Gómez Burbano Kevin Alexis
Published: October 2022

Dentro del proceso de investigación llevado a cabo entre la Fundación Universitaria de Popayán “FUP” y el Parque Tecnológico de Innovación del Café “Técnicafé”, se ha generado un prototipo de aglomerado basado en el aprovechamiento industrial de residuos de la producción y procesamiento de café. Se ha iniciado el proceso de ruta de transferencia tecnológica el cual conduce a un escalamiento industrial de esta nueva tecnología: Consiste en la creación del diseño industrial del proceso de producción de madera aglomerada. Este proyecto contribuye en el aumento de la competitividad de la cadena productiva de la industria cafetera en el departamento de Cauca, beneficiando directamente a un gran porcentaje de las 95.000 familias que derivan su sustento de la producción del grano de café en esta región.
ESTRATEGIA DIDÁCTICA PARA EL ENTRENAMIENTO DE LA INTELIGENCIA EMOCIONAL EN EL PROCESO DE FORMACIÓN DEL INGENIERO: UNA EXPERIENCIA SIGNIFICATIVA DE APRENDIZAJE EN AULA PARA LA UNIVERSIDAD TECNOLÓGICA DEL CHOCÓ, COLOMBIA
Authors: Sarria Palacio Ana Mercedes , Peláez Valencia Luis Eduardo , Parra Jorge
Published: October 2022

Los programas de ingeniería tradicionalmente no han incluido las emociones como elemento central del aprendizaje en los programas de formación, limitando la capacidad de comprender las relaciones transactivas con el entorno, con otros y ellos mismos. En la actualidad se consideran a las emociones como parte fundamental del proceso de enseñanza por la influencia de estas en el aprendizaje, y con ello lograr la inclusión del desarrollo de habilidades y competencias sociales que hacen al profesional competente y pertinente para atender las necesidades y requerimientos del entorno concibiendo que el fin último de las profesiones es, precisamente, la sociedad. De esta forma se promueve un proceso de formación de carácter sistémico. Este trabajo reporta una experiencia de formación sistémica de aula con estudiantes de la facultad de la ingeniería de la Universidad Tecnológica del Chocó mediante la aplicación de la autorreflexión que reconoce el rol de las emociones en la formación. Su objetivo fue identificar percepciones y emociones relacionadas con ellos mismos y su entorno cercano. A partir de esto, los estudiantes recibieron información adicional que les permitiera hacer metacognición sobre sus emociones desarrollando así una nueva mirada que facilitará lidiar con los sentimientos que se generan en el proceso de formación como parte del desarrollo integral adoptado en la fundamentación teórica institucional en el desarrollo del ser Esto permitió reconocer la necesidad de los estudiantes de ser oídos y vistos como personas con temores y expectativas que residen principalmente en temas familiares y del desarrollo personal. Los profesores por su parte reconocieron la importancia de incluir en el proceso cognitivo el desarrollo de habilidades blandas, así como la gestión de las emociones, para finalmente concluir en el nivel de impacto que pudo generar este reconocimiento en las posibilidades de aprendizaje. Estos aprendizajes alrededor del rol de las emociones en la formación en Ingeniería cobran una relevancia en momentos de crisis como los vividos durante la pandemia ya que permiten a los programas reconocer el rol de las emociones en la formación.
ANÁLISIS DEL IMPACTO EN LA PRODUCTIVIDAD EMPRESARIAL DE LAS ESCUELAS DE DESTREZAS DE LAS EMPRESAS MADECENTRO, NOEL Y CORONA DE LA CIUDAD DE MEDELLÍN
Authors: Rojas Arenas Iván Darío , Restrepo Hoyos Kelly Johana , Hernández Cossío Katherine Alejandra , Villa Marín Vanessa Yurley , Rodríguez Álvarez Andrés Felipe
Published: October 2022

La productividad de las empresas se mide en gran parte por el nivel de capacitación de sus empleados, de manera que puedan aplicar sus conocimientos, habilidades y destrezas en la solución de problemáticas reales en sus sitios de trabajo. Así las cosas, los procesos de capacitación se convierten en una herramienta fundamental precisamente para aumentar la productividad de las organizaciones. En este sentido, las escuelas de destrezas emergen como una alternativa viable en los procesos de mejora en las empresas, en la medida que permiten capacitar a los empleados para un desempeño óptimo de sus funciones. En el presente trabajo se pretende analizar cómo ha sido el impacto de las escuelas de destrezas en dos empresas específicas del Departamento de Antioquia, a partir de una metodología de tipo descriptiva y con enfoque mixto, dividida en tres etapas. Como resultado final se espera obtener una hoja de ruta para la evaluación del impacto de las escuelas de destrezas en las organizaciones, sustentada en la evaluación de los indicadores construidos y la información recopilada en las empresas estudiadas. De igual manera se espera que este proyecto investigativo sirva como insumo para trabajos posteriores en la misma línea temática.
ARTICULAR LA DIDÁCTICA DE LA ENSEÑANZA DE LOS FUNDAMENTOS DE PROGRAMACIÓN PARA ESTUDIANTES DE EDUCACIÓN MEDIA DE LAS INSTITUCIONES DE LA CIUDAD DE NEIVA
Authors: García Perdomo Edisney , Rodríguez Herrera Tomás Octavio , Borrero Suárez Santiago , Conde García Michael Herzen , Ibarra Gutiérrez Nicolás Alberto
Published: October 2022

La educación media en Colombia según el Articulo “La educación en Colombia” realizada por la OCDE, tiene una duración de dos años y en teoría está dirigida a los estudiantes entre los 15 y 16 años (grados 10 y 11) (OCDE, 2016). Desde el año 2012, la educación media es gratuita en Colombia y el objetivo es que para el año 2030 sea universal y obligatoria. Cada vez más jóvenes colombianos han logrado obtener el título de educación media, sin embargo, los resultados de aprendizaje son bajos según los estándares nacionales e internacionales. Además, muchos de los estudiantes no cuentan con una apropiada formación en la media técnica, situación que les dificulta alcanzar las competencias necesarias para trabajar o continuar su proceso de formación universitaria. La Corporación Universitaria del Huila-CORHUILA, a través del Programa de Ingeniería de Sistemas sensibiliza a los estudiantes con prácticas extramuros para llevar conocimiento de manera voluntaria que permitan fortalecer las capacidades de los aprendices de la media Técnica, involucrando a las Instituciones Educativas de Neiva en el proceso de Desarrollo de Software. En mencionado programa se desarrolla el módulo de lógica de programación y algoritmia donde existen grandes dificultades de interpretación y análisis de algoritmos, debido a la implementación de una metodología de enseñanza inadecuada por parte del docente titular de la asignatura, el cual no cuenta con los conocimientos para impartir estas temáticas. En las I.E Atanasio Girardot, Técnico Superior y el Colegio Adventista Baluarte Interamericano se implementan talleres teóricos y prácticos, relacionados con lógica de programación por medio de herramientas como PSEINT en donde los aprendices evidencian sus primeros pasos en programación utilizando un pseudolenguaje en español, logrando interpretar de forma sencilla y práctica el tema de la algoritmia, llegando a más de 120 aprendices jóvenes, con los cuales se comparten diferentes experiencias que los motive a iniciar una carrera universitaria relacionada con tecnologías de la información. Finalmente, esta proyección social ofrece la oportunidad al aprendiz de las I.E perteneciente a la media técnica que, por medio de estos talleres, ellos aprendan a pensar de una forma más analítica, estimulando la perseverancia y la dedicación como objetivo para encaminarlos a ser personas emprendedoras y que no sean solo consumidores de TI, ayudándolos a identificar su potencial como aporte al desarrollo tecnológico de la región.
ESTIMACIÓN DEL MÓDULO DE RIGIDEZ DEL BALSO Y EL PVC USANDO UN TORSIÓMETRO DE BAJO COSTO Y CORRELACIÓN DE IMÁGENES DIGITALES
Authors: Guerrero Mejía Juan Diego , Vargas Gamboa Jeisson Stiven , Parada Sepúlveda Raúl Andrés , Mosquera Gutiérrez Edwin Arnoldo , Benjumea Royero José , Cotes Prieto David Sebastián , Villán Pacheco Valentina , Martínez Chinchilla Jeisi Jelizeth
Published: October 2022

Las propiedades mecánicas de los materiales pueden determinase a partir del estudio de sus respuestas frente a cargas externas. Estas permiten describir o predecir el comportamiento y resistencia de elementos que hacen parte de sistemas, por ello es de vital importancia determinarlas con el fin de emplear dichos materiales en los diferentes problemas de ingeniería estructural y seleccionar cuál es el recurso más factible tanto funcional como económicamente. Este trabajo de investigación, desarrollado en el marco de la asignatura mecánica de sólidos del programa de pregrado en ingeniería civil de la Universidad Industrial de Santander, expone los resultados de ensayos a torsión realizados a probetas de madera balso y Policloruro de Vinilo (PVC), El objetivo del trabajo fue determinar el módulo de rigidez de ambos materiales usando un torsiómetro de bajo costo y la técnica de correlación de imágenes digitales. El torsiómetro fue diseñado por los docentes a cargo del curso y tuvo un costo a la institución realmente bajo en comparación a los equipos disponibles en el mercado. Antes de realizar el ensayo de cada probeta, se determinó un rango de carga máximo permitido con el fin de no sobrepasar el límite lineal- elástico de cada material, con base en propiedades teóricas obtenidas de la literatura y aplicando los conocimientos teóricos adquiridos en la asignatura. El componente tecnológico aplicado en los ensayos consistió en la captura de datos de desplazamiento usando patrones discretos y estocásticos en el software GOM Correlate 2019. De igual manera para los resultados de cada patrón se emplearon diversas formas de análisis, como la relación de la deformación unitaria y el esfuerzo cortante mediante gráficas, y operaciones algebraicas. Los resultados obtenidos experimentalmente de módulo de rigidez concuerdan con los reportados en la literatura, por lo cual se concluye que la metodología propuesta es válida y consiste en una oportunidad viable para la introducción de los estudiantes de ingeniería al campo de la experimentación en su programa de pregrado.
Pengetahuan dan Sikap Perilaku Hidup Bersih dan Sehat Siswa SDN 001 Buluh Cina Terhadap Tungau Debu Rumah
Authors: Haslinda Lilly , Agustiandi Andri
Published: October 2022

House dust mites (HDM) consists of a group of species of mites. Their size is very small and caused allergic reaction. A Parasitology house based survey conducted by Riau Provincial Health Office at SDN 001 Buluh Can at Kampar regency in 2014 found the high proportion of HDR (40,3%). The objective of this study was to find out the description of Clean and Healty Lifestyle (CAHL) knowledge and attitude of student of SDN 001 Buluh Cina, Kabupaten Kampar, Provinsi Riau. This study was a descriptive cross sectional with total number of are 97 respondents. This study showed that knowledge of CAHL toward HDM of 67 students are low (71,1%), 14 students (14,4%) are less and 14 studens(14,4%) are enough. Attitude of CAH Ltoward HDM of 54 student’s (55,7%) are negative and 43 students (44,3%) are positive. From this study concluded that the student’s knowledge of CAHL are low and the student’s attitude of CAHL toward HDM are negative.
Rare Case: Ovarian Cysts in Child
Authors: R Wahid Tubagus Odih
Published: October 2022

An ovarian cyst is a sac filled with liquid or semiliquid material that arises in an ovary. Those cysts were mostly found in women aged 20-50 years. The incidence is 10: 100.000 women. This report reports a case of a child patient aged two years who came to Arifin Achmad Hospital with a chief complaint there is a mass in the lower abdomen area. From the physical examination, the lump in the lower abdomen area was obtained. We performed, laparotomy exploration with cystectomy and found a left ovarian cyst size 12 x 12 x 15 cm.