bluuebunny/crossref_metadata_2025 huggingface dataset:
Carrier Rate and Mutant Allele Frequency of GM1 Gangliosidosis in Miniature Shiba Inus (Mame Shiba): Population Screening of Breeding Dogs in Japan
Authors: Pervin Shahnaj , Islam Md Shafiqul , Yorisada Yamato , Sakai Aya , Masamune Shimma , Yabuki Akira , Rakib Tofazzal Md , Maki Shinichiro , Tacharina Martia Rani , Yamato Osamu
Published: May 2022

GM1 gangliosidosis is a progressive, recessive, autosomal, neurodegenerative, lysosomal storage disorder that affects the brain and multiple systemic organs due to an acid β-galactosidase deficiency encoded by the GLB1 gene. This disease occurs in the Shiba Inu breed, which is one of the most popular traditional breeds in Japan, due to the GLB1:c.1649delC (p.P550Rfs*50) mutation. Previous surveys performed of the Shiba Inu population in Japan found a carrier rate of 1.02–2.94%. Currently, a miniature type of the Shiba Inu called “Mame Shiba”, bred via artificial selection to yield smaller individuals, is becoming more popular than the standard Shiba Inu and it is now one of the most popular breeds in Japan and China. The GM1 gangliosidosis mutation has yet to be surveyed in the Mame Shiba population. This study aimed to determine the frequency of the mutant allele and carrier rate of GM1 gangliosidosis in the Mame Shiba breed. Blood samples were collected from 1832 clinically healthy adult Mame Shiba Inus used for breeding across 143 Japanese kennels. The genotyping was performed using a real-time PCR assay. The survey found nine carriers among the Mame Shibas, indicating that the carrier rate and mutant allele frequency were 0.49% and 0.00246, respectively. This study demonstrated that the mutant allele has already been inherited by the Mame Shiba population. There is a risk of GM1 gangliosidosis occurrence in the Mame Shiba breed if breeders use carriers for mating. Further genotyping surveys are necessary for breeding Mame Shibas to prevent the inheritance of this disease.
Confounding Rules Can Hinder Conservation: Disparities in Law Regulation on Domestic and International Parrot Trade within and among Neotropical Countries
Authors: Romero-Vidal Pedro , Carrete Martina , Hiraldo Fernando , Blanco Guillermo , Tella José L.
Published: May 2022

Wildlife trade is a major driver of biodiversity loss worldwide. To regulate its impact, laws and regulations have been implemented at the international and national scales. The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has regulated the international legal trade since 1975. However, an important volume of illegal trade—mainly within countries—continues to threaten several vertebrate groups, which could be due to a lack of specific legislation or enforcement of existing regulations. Our aim was to gain a more accurate picture of poaching and legal possession of native parrots as pets in the Neotropics, where illegal domestic trade is currently widespread. We conducted a systematic search of the laws of each of the 50 countries and overseas territories, taking into account their year of implementation and whether the capture, possession and/or sale of parrots is permitted. We compared this information with legal exports reported by CITES to assess differences between the enforcement of international and national trade regulations. We found that only two countries (Guyana and Suriname) currently allow the capture, trade and possession of native parrots, while Peru allowed international legal trade until recently. The other countries have banned parrot trade from years to decades ago. However, the timing of implementation of international and national trade regulations varied greatly between countries, with half of them continuing to export parrots legally years or decades after banning domestic trade. The confusion created by this complex legal system may have hindered the adoption of conservation measures, allowing poaching, keeping and trade of protected species within and between neighboring countries. Most countries legally exported Neotropical parrot species which were not native to those countries, indicating that trans-border smuggling often occurred between neighboring countries prior to their legal exportations, and that this illicit activity continues for the domestic trade. Governments are urged to effectively implement current legislation that prohibits the trapping and domestic trade of native parrots, but also to develop coordinated alliances and efforts to halt illegal trade among them. Otherwise, illegal trade will continue to erode the already threatened populations of a large number of parrot species across the Neotropics.
Swedish Efforts to Contain Antibiotic Resistance in the Environment—A Qualitative Study among Selected Stakeholders
Authors: Björkman Ingeborg , Röing Marta , Eriksen Jaran , Stålsby Lundborg Cecilia
Published: May 2022

Antibiotic resistance is a serious global threat to human and animal health. In this study, we explored perceptions of work to contain antibiotic resistance with a focus on the environment. Nine stakeholders from six different areas were interviewed in 2018. A short information update was given by informants from four of the areas in 2021. Interview transcripts were analyzed by conventional content analysis. The stakeholders’ perceptions were concluded in three categories: “examples of actions taken to combat antibiotic resistance”, “factors influencing work”, and “factors hindering work”. All informants reported having a role to play. Some of them were very engaged in this issue, whereas among others, antibiotics and resistance were just one part of a general engagement. To be able to act, the policymaker stakeholders asked for more knowledge about antibiotics in the environment and possible actions to take. Actions from the government were requested by several informants. Coordination of the work to combat antibiotic resistance in the environment was not recognized and the One Health approach was known at policy level but not among practitioners. Still, actions seemed to be coordinated, but this was, according to the stakeholders, based on findings from research in their area rather than on strategies developed by national authorities.
A 3D Fluorescence Classification and Component Prediction Method Based on VGG Convolutional Neural Network and PARAFAC Analysis Method
Authors: Ruan Kun , Zhao Shun , Jiang Xueqin , Li Yixuan , Fei Jianbo , Ou Dinghua , Tang Qiang , Lu Zhiwei , Liu Tao , Xia Jianguo
Published: May 2022

Three-dimensional fluorescence is currently studied by methods such as parallel factor analysis (PARAFAC), fluorescence regional integration (FRI), and principal component analysis (PCA). There are also many studies combining convolutional neural networks at present, but there is no one method recognized as the most effective among the methods combining convolutional neural networks and 3D fluorescence analysis. Based on this, we took some samples from the actual environment for measuring 3D fluorescence data and obtained a batch of public datasets from the internet species. Firstly, we preprocessed the data (including two steps of PARAFAC analysis and CNN dataset generation), and then we proposed a 3D fluorescence classification method and a components fitting method based on VGG16 and VGG11 convolutional neural networks. The VGG16 network is used for the classification of 3D fluorescence data with a training accuracy of 99.6% (as same as the PCA + SVM method (99.6%)). Among the component maps fitting networks, we comprehensively compared the improved LeNet network, the improved AlexNet network, and the improved VGG11 network, and finally selected the improved VGG11 network as the component maps fitting network. In the improved VGG11 network training, we used the MSE loss function and cosine similarity to judge the merit of the model, and the MSE loss of the network training reached 4.6 × 10−4 (characterizing the variability of the training results and the actual results), and we used the cosine similarity as the accuracy criterion, and the cosine similarity of the training results reached 0.99 (comparison of the training results and the actual results). The network performance is excellent. The experiments demonstrate that the convolutional neural network has a great application in 3D fluorescence analysis.
Droplets Transmission Mechanism in a Commercial Wide-Body Aircraft Cabin
Authors: Kong Benben , Zou Yitao , Cheng Mengmeng , Shi Hong , Jiang Yanlong
Published: May 2022

COVID-19 is a respiratory infectious disease that spreads readily between people, and an urgent issue of passengers’ exposure risk assessment in commercial aircraft has been raised because an aircraft cabin as a confined space may carry and transmit the disease worldwide. In this study, the droplets transmission process under different ventilation systems in a twin-aisle wide-body aircraft was studied using CFD simulations and the infection risk of passengers was assessed by the improved Wells–Riley model. Numerical results found that the transmission mechanism of droplets in the aircraft cabin was different depending on the type of ventilation systems and the location of the infectious source. Annular airflow could effectively enhance the ability of droplets transmission, while direct airflow, represented by displacement ventilation, could significantly inhibit droplets transmission. Accordingly, a new type of ventilation system was proposed based on the concept that the overall space is organized by annular airflow and the local area is direct airflow. Compared with sidewall mixing ventilation system, the infection risk of the new ventilation system presented in this study is reduced by 27%.
Experimental and Geant4 Simulation Study of MURA Mask for Scintimammography
Authors: Alnafea Mohammed A. , Shamma Khaled , Kadri Omrane
Published: May 2022

Gamma rays have been extensively investigated for breast imaging using collimators; however, the coded-aperture technique needs to be investigated more. In this paper, we propose an experimental study and Geant4 simulations of MURA mask breast imaging. First, we compare the experimental data against the simulation results carried out using Geant4 (version 10.4) and accreditation phantom. Second, we virtually extend our work by changing the tumor-to-background (TBR) and lesion location parameters. We used 99mTc as a radioactive source. Good agreement has been seen for the benchmark stage, especially in terms of tumor localization. Moreover, the calculated full width at half maximum (FWHM) and contrast for decoded images (having average values of 8 and 3.5 for TBR between 2 and 10) permitted us to conclude that we can accurately localize small lesions up to lower TBR values by following the decoding procedure of deducing the image of a “blank phantom” (phantom with TBR = 1) every time within a matlab-based program. Hence, this work can be considered a continuously added value to previous investigations for scintimammography imaging.
Research on the Influence of Tractor Parameters on Shift Quality, Based on Uniform Design
Authors: Wang Junyan , Xia Changgao , Fan Xin , Cai Junyu
Published: May 2022

This paper mainly studies the influence of tractor parameters on shift quality. The kinetic theoretical model of the powertrain system was deduced, and then the simulation model was established by using AMESim simulation software. The acceptable jerk and shift time were selected as the evaluation indexes of shift quality. The influence of engine speed, the tractive resistance of the tractor, the clutch oil pressure and the orifice diameter on the above evaluation indexes were quantitatively studied. The simulation test, under the influence of a single parameter, was carried out using the parameter analysis method. After this, the uniform design experimentation method was used to carry out the simulation test, under the influence of combined parameters. The results showed that in order to improve the shift quality, it is necessary to focus on the selection of clutch oil pressure and orifice diameter.
Advances in Primary Progressive Aphasia
Authors: Matias-Guiu Jordi A. , Laforce Robert , Lavoie Monica , Utianski Rene L.
Published: May 2022

Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive and predominant language impairment [...]
In Vitro and In Vivo Anticancer Activity of Basil (Ocimum spp.): Current Insights and Future Prospects
Authors: Perna Simone , Alawadhi Hajar , Riva Antonella , Allegrini Pietro , Petrangolini Giovanna , Gasparri Clara , Alalwan Tariq A. , Rondanelli Mariangela
Published: May 2022

Background: Cancer is an irregular proliferation of cells that starts with a gene mutation that alters cellular function, is triggered by several factors, and can be inherited or acquired. The aim of this review is to discuss the anticancer activity of basil and its components’ strength, focusing on its implication in cancer prevention and treatment. Methods: This systematic review involves all of the studies published from 1 January 2010 through 1 January 2022. Results: In this review, 16 research articles are included to discuss the potential anticancer ability of the extracts of various Ocimum basilicum varieties at various dosages, applied to different cancer cells. Of those 16 articles, 2 were in vivo studies, 13 were in vitro studies, and 1 study conducted both in vivo and in vitro experiments. Antioxidants and other bioactive compounds in basil leaves show important potential anticancer activity at dosage of 4 mg/mL as aqueous extract or essential oil up to 200 µg/mL could slow-down tumor growth and progression with regards to cell death and viability inhibition. At dosages from 50 to 500 µg/mL is effective as anti-proliferative activities. cytotoxicity, inducing apoptosis, slowing down tumor growth, and especially cell cycle arrest, both in vivo and in vitro. Human studies show effects at dosages from 1 to 2.5 mg/daily on general vital activities and on reducing cytokines activity. Conclusions: Based on 16 published studies, basil demonstrates important anticancer activities in vivo and vitro models, and it could act as a potential cancer.
The Role of Matrix-Bound Extracellular Vesicles in the Regulation of Endochondral Bone Formation
Authors: Boyan Barbara D. , Asmussen Niels C. , Lin Zhao , Schwartz Zvi
Published: May 2022

Matrix vesicles are key players in the development of the growth plate during endochondral bone formation. They are involved in the turnover of the extracellular matrix and its mineralization, as well as being a vehicle for chondrocyte communication and regulation. These extracellular organelles are released by the cells and are anchored to the matrix via integrin binding to collagen. The exact function and makeup of the vesicles are dependent on the zone of the growth plate in which they are produced. Early studies defined their role as sites of initial calcium phosphate deposition based on the presence of crystals on the inner leaflet of the membrane and subsequent identification of enzymes, ion transporters, and phospholipid complexes involved in mineral formation. More recent studies have shown that they contain small RNAs, including microRNAs, that are distinct from the parent cell, raising the hypothesis that they are a distinct subset of exosomes. Matrix vesicles are produced under complex regulatory pathways, which include the action of steroid hormones. Once in the matrix, their maturation is mediated by the action of secreted hormones. How they convey information to cells, either through autocrine or paracrine actions, is now being elucidated.
Symmetry of Wavefunction at the Interface of Fe/MgO Magnetic Tunneling Junction
Authors: Sakurai Hiroshi , Takahashi Manabu , Suzuki Kosuke , Tamura Takuro , Homma Satoshi , Tsuji Naruki , Sakurai Yoshiharu
Published: May 2022

We measured the anisotropy of Magnetic Compton profiles (MCP) in the Fe/MgO multilayers and compared it with band structure calculations. At the Fe/MgO interface, the |m| = 1 state in the minority band is suppressed, which in turn promotes the spin-polarized occupation of the |m| = 1 state. At the Fe/FeO interface of intentionally oxidized Fe/MgO multilayers, the occupations of the magnetic quantum number are almost equal (spherical) in the majority band and minority band, and therefore, the spin-polarization occupancy is also almost equal (spherical). These results contribute to the material design for MTJs as high-performance spintronic devices.
Successful Treatment with Selpercatinib for Ectopic Cushing’s Syndrome Due to Medullary Thyroid Cancer
Authors: Ragnarsson Oskar , Piasecka Marta , Hallqvist Andreas
Published: May 2022

Selpercatinib, a RET kinase inhibitor, is an effective treatment for patients with medullary thyroid cancer with RET mutations. In this paper, we present the case of a 62-year-old man with ectopic Cushing’s syndrome due to medullary thyroid cancer who received treatment with selpercatinib. Six months later, all the cushingoid features had resolved, and s-calcitonin had decreased from 580 pmol/L to 3.5 pmol/L (normal < 3). After further 6 months, s-calcitonin had normalized (1.5 pmol/L), and radiological evaluation showed a profound tumour volume reduction. We are aware of two other cases where treatment with selpercatinib has also been successful. Thus, selpercatinib may be a promising treatment alternative in patients with ectopic Cushing’s syndrome due to medullary thyroid cancer, especially when other treatment options are ineffective or not tolerated.
First Record of the Phylum Gnathostomulida in the Southern Ocean
Authors: Sterrer Wolfgang , Sørensen Martin V. , Cecchetto Matteo , Martínez Alejandro , Sabatino Raffaella , Eckert Ester M. , Fontaneto Diego , Schiaparelli Stefano
Published: May 2022

We report for the first time the occurrence of at least two species of the phylum Gnathostomulida in the Southern Ocean, along the shores of the Ross Sea in Antarctica. At least one species for each of the orders of the phylum (Filospermoidea and Bursovaginoidea) was found using both morphological inspection and DNA metabarcoding of the shallow marine sediments collected with a Van Veen grab or by scuba diving in the area facing the Italian research station “Mario Zucchelli”.
PSMA-Positive Follicular Thyroid Carcinoma Incidentally Detected by [68Ga]Ga-PSMA-11 PET/CT: Correlation with Immunohistology Confirms Neovascular PSMA-Expression
Authors: Rosar Florian , Burgard Caroline , Neubert Christian , Stahl Phillip , Khreish Fadi , Ezziddin Samer
Published: May 2022

We present an interesting image of an intense PSMA-positive follicular thyroid carcinoma incidentally detected by [68Ga]Ga-PSMA-11 PET/CT in a 76-year-old man with biochemical recurrence of prostate cancer. Immunohistochemical staining demonstrated PSMA expression in the endothelial cells of tumor tissue. This interesting image should remind colleagues to consider malignant thyroid neoplasia in PSMA-positive thyroid lesions.
Mongolian Pre-Service English Teachers’ Voices about Their Teaching Practicum Experiences
Authors: Marav Daariimaa
Published: May 2022

Despite the growing uptake of the English language by Mongolian youth and policy initiatives at the governmental level that have emphasized English education, there is very limited internationally available discussion and research on English language teacher education in Mongolia. Thus, the paper aims to examine teaching practicum experiences of pre-service English teachers in Mongolian secondary school settings and explore what challenges they face. Eleven pre-service English teachers, who completed their 12-week teaching practicum in secondary schools in Ulaanbaatar, participated in this study by writing personal narratives on their teaching practicum experiences. The findings indicate that the participants struggled in their teaching contexts due to the lack of mentoring by public school mentor teachers, insufficient university-school partnerships, and classroom-level constraints caused by the mismatch between what they had learned at university and the realities faced in school classrooms. It is recommended to develop a comprehensive teacher development program to improve the quality of both in-service and pre-service English teachers, and to reduce educational inequality associated with access to quality English language education. Furthermore, incorporating social justice education into English teacher preparation programs is important to help future teachers become more critical, reflexive, and transformative.
Bayesian Workflow and Hidden Markov Energy-Signature Model for Measurement and Verification
Authors: Rouchier Simon
Published: May 2022

A Bayesian data analysis workflow offers great advantages to the process of measurement and verification, including the estimation of savings uncertainty regardless of the chosen numerical model. However, it is still rarely used in practice, perhaps because practitioners are less familiar with the required tools. The present work documents a Bayesian methodology for the assessment of energy savings at the scale of a whole facility, following an energy-conservation measure. The first model, an energy signature commonly used in practice, demonstrates the steps of the Bayesian workflow and illustrates its advantages. The posterior distributions obtained by training this first model are used as prior distributions for a second, more complex model. This so-called “hidden Markov energy signature” model combines the energy signature with a hidden Markov model at an hourly resolution, and allows detection of occupancy. It has a large number of parameters and would likely not be identifiable without the Bayesian workflow. The results illustrate the advantages of the Bayesian methodology for measurement and verification: a probabilistic description of all variables, including predictions of energy use and savings; the applicability to any model structure; the ability to include prior knowledge to facilitate training complex models. Savings are estimated by the new hidden Markov energy-signature model with a much lower uncertainty than with a lower-resolution model. The highlights of the paper are twofold: it serves as a tutorial on Bayesian inference for measurement and verification; it also proposes a new flexible model structure for hourly prediction of energy use and occupancy detection.
Experimental Investigation into Three-Dimensional Spatial Distribution of the Fracture-Filling Hydrate by Electrical Property of Hydrate-Bearing Sediments
Authors: Zhao Jinhuan , Liu Changling , Chen Qiang , Zou Changchun , Liu Yang , Bu Qingtao , Kang Jiale , Meng Qingguo
Published: May 2022

As a future clean energy resource, the exploration and exploitation of natural gas hydrate are favorable for solving the energy crisis and improving environmental pollution. Detecting the spatial distribution of natural gas hydrate in the reservoir is of great importance in natural gas hydrate exploration and exploitation. Fracture-filling hydrate, one of the most common types of gas hydrate, usually appears as a massive or layered accumulation below the seafloor. This paper aims to detect the spatial distribution variation of fracture-filling hydrate in sediments using the electrical property in the laboratory. Massive hydrate and layered hydrate are formed in the electrical resistivity tomography device with a cylindrical array. Based on the electrical resistivity tomography data during the hydrate formation process, the three-dimensional resistivity images of the massive hydrate and layered hydrate are established by using finite element forward, Gauss–Newton inversion, and inverse distance weighted interpolation. Massive hydrate is easier to identify than layered hydrate because of the big difference between the massive hydrate area and surrounding sediments. The diffusion of salt ions in sediments makes the boundary of massive hydrate and layered hydrate change with hydrate formation. The average resistivity values of massive hydrate (50 Ω⋅m) and layered hydrate (1.4 Ω⋅m) differ by an order of magnitude due to the difference in the morphology of the fracture. Compared with the theoretical resistivity, it is found that the resistivity change of layered hydrate is in accordance with the change tendency of the theoretical value. The formation characteristic of massive hydrate is mainly affected by the pore water distribution and pore microstructure of hydrate. The hydrate formation does not necessarily cause the increase in resistivity, but the increase of resistivity must be due to the formation of hydrate. The decrease of resistivity in fine-grains is not obvious due to the cation adsorption of clay particles. These results provide a feasible approach to characterizing the resistivity and growth characteristics of fracture-filling hydrate reservoirs and provide support for the in-situ visual detection of fracture-filling hydrate.
Arc Voltage Distortion as a Source of Higher Harmonics Generated by Electric Arc Furnaces
Authors: Olczykowski Zbigniew
Published: May 2022

Due to high unit capacities, electric arc furnaces are among the receivers that significantly affect the power system from which they are supplied. Arc furnaces generate a number of disturbances to the power grid, including fast-changing voltage fluctuations causing the phenomenon of flickering light, asymmetry, and deformation of the voltage curve. The main issues discussed in the article are problems related to the distortion of current and voltage waveforms, resulting from the operation of electric arc furnaces. An analysis of the indices characterizing the voltage distortion recorded in the supply network of the arc furnaces is presented. The changes in the range of current and voltage waveform deformation in individual smelting phases in the arc furnace are also presented. Furthermore, the changes in the degree of deformation of the current and voltage waveforms in the individual smelting phases in an arc furnace are presented. A multi-voltage electric arc model used in computer simulations is proposed.
Neuropeptide Y in Spotted Scat (Scatophagus Argus), Characterization and Functional Analysis towards Feed Intake Regulation
Authors: Assan Daniel , Wang Yaorong , Mustapha Umar Farouk , Ndandala Charles Brighton , Li Zhiyuan , Li Guang-Li , Chen Huapu
Published: May 2022

Neuropeptide Y (Npy) is an intricate neuropeptide regulating numerous physiological processes. It is a highly conserved peptide known to improve feed intake in many vertebrates, including fishes. To enlighten the mechanism of Npy in spotted scat feed intake control, we cloned and identified the Npy cDNA sequence. We further examined its expression in some tissues and explored its expression effects at different time frames (hours and days). Here, we discovered that spotted scat Npy comprised a 300 bp open reading frame (ORF) and a 99 amino acid sequence. Npy was identified to be expressed in all tissues examined. Using in situ hybridization examination, we proved that npy has a wide expression in the brain of the spotted scat. Furthermore, the expression of npy in the hypothalamus significantly increased one hour after feeding (p < 0.05). Further, it was revealed that npy expression significantly increased in fish that were fasted for up to 5 days and significantly increased after refeeding from the 8th to the 10th day. This suggests that Npy is an orexigenic peptide, and hence, it increases food intake and growth in the spotted scat. Additionally, results from in vitro and in vivo experiments revealed that Npy locally interacts with other appetite-regulating peptides in the spotted scat hypothalamus. This research aimed to set a fundamental study in developing the feed intake regulation, improving growth and reproduction, which is significant to the aquaculture industry of the spotted scat.
Genome-Wide Identification of the SAMS Gene Family in Upland Cotton (Gossypium hirsutum L.) and Expression Analysis in Drought Stress Treatments
Authors: Sun Fenglei , Ma Jun , Wang Penglong , Yang Yanlong
Published: May 2022

Cotton is an important commercial crop whose growth and yield are severely affected by drought. S-adenosylmethionine (SAM) is widely involved in the plant stress response and growth regulation; however, the role of the S-adenosylmethionine synthase (SAMS) gene family in this process is poorly understood. Here, we systematically analyzed the expression of SAMS genes in Upland Cotton (Gossypium hirsutum L.). A total of 16 SAMS genes were identified, each with a similar predicted structure. A large number of cis-acting elements involved in the response to abiotic stress were predicted based on promoter analysis, indicating a likely important role in abiotic stress responses. The results of qRT-PCR validation showed that GhSAMS genes had different expression patterns after drought stress and in response to drought stress. Analysis of a selected subset of GhSAMS genes showed increased expression in cultivar Xinluzhong 39 (drought resistant) when compared to cultivar Xinluzao 26 (drought-sensitive) upland cotton. This study provides important relevant information for further study of SAMS genes in drought resistance research of upland cotton, which is helpful for drought-resistance improvement of upland cotton.
Attitudes and Perceptions of Health Leaders for the Quality Enhancement of Workforce in Saudi Arabia
Authors: Hejazi Majid M. , Al-Rubaki Shayma S. , Bawajeeh Othman M. , Nakshabandi Ziad , Alsaywid Basim , Almutairi Eman M. , Lytras Miltiadis D. , Almehdar Manal H. , Abuzenada Maha , Badawood Halla
Published: May 2022

Background and Aim: Besides the unique exposure and experience of health leaders in facing challenges and overcoming them, and the relatively fewer articles relating to the perception of health leaders in workforce quality enhancement, health leadership plays a crucial role in redirecting the workforce, increasing job satisfaction, professional development, and burnout prevention. Thus, this study aimed to understand the current healthcare workforce quality and future expectations from the attitudes and perceptions of health leaders. Methods: A qualitative research was carried out using semi-structured interviews consisting of 24 different questions. Participants of the study were healthcare leaders from different backgrounds and governmental institutions. All interviews were recorded, transcribed, and then analyzed using thematic analysis via the N-Vivo program. Results: Eleven participants were involved in the study, with one female and ten males. A thematic analysis and N-Vivo program yielded 5 main themes: (1) workforce competency, (2) health transformation, (3) leadership, (4) workforce planning, and (5) healthcare quality, with 22 emerging sub-themes. Moreover, participants responded with different attitudes and perceptions. Conclusion: Health leaders are satisfied with the current direction of workforce competency and planning, yet fragmentation of the system and poor accessibility may need further enhancement. Furthermore, misutilization of services and the uncertainty of the future and talent pool are potential barriers for capability building. Moreover, with the existing gap in the workforce, health leaders believe that privatization and corporatization may have a positive effect. Aside from that, Saudization with the current plan of having a minimum standard of accepting non-Saudis in certain areas might benefit in maintaining competition and enriching experience. However, catching up with further research in healthcare quality in Saudi Arabia is needed because of the ongoing health transformation.
Productivity Losses Due to Diabetes in Urban Rural China
Authors: Hao Hongying , Nicholas Stephen , Xu Lizheng , Leng Anli , Sun Jingjie , Han Zhiyan
Published: May 2022

Background: Productivity losses due to diabetes are increasing in China, but research about the impact of diabetes on productivity in urban and rural areas requires further in-depth study. This article provides the first estimate of the cost of productivity losses attributed to diabetes in individuals 20–69 years old in urban and rural areas of China. Methods: The human capital approach is employed to measure the productivity losses attributed to absenteeism, presenteeism, labor force dropout, and premature deaths due to diabetes of the 20–69-year-old population of males and females in urban and rural areas of China. Based on the life table modelling, we calculate the years of potential life lost and working years of life lost of people with diabetes. Results: In 2017, we estimated that there were 100.46 million people with diabetes, with the total cost of productivity losses being USD 613.60 billion, comprising USD 326.40 billion from labor force dropout, USD 186.34 billion from premature death, USD 97.71 billion from absenteeism, and USD 27.04 billion from presenteeism. Productivity loss was greater in urban (USD 490.79 billion) than rural areas (USD 122.81 billion), with urban presenteeism (USD 2.54 billion) greater than rural presenteeism (USD 608.55 million); urban absenteeism (USD 79.10 billion) greater than rural absenteeism (USD 18.61 billion); urban labor force dropout (USD 261.24 billion) greater than rural labor force dropout (USD 65.15 billion); and urban premature death (USD 147.90 billion) greater than rural premature death (USD 38.44 billion). Conclusions: Diabetes has a large and significant negative impact on productivity in urban and rural China. Productivity loss is significantly higher in urban versus rural regions. Further investment is required in the prevention, diagnosis, and control of diabetes in under-resourced health services in rural locations as well as in urban areas, where most diabetes cases reside. Specifically, targeted and effective diabetes prevention and management actions are urgently required.
Grain Production Space Reconstruction and Its Influencing Factors in the Loess Plateau
Authors: Qin Zhangxuan , Liu Xiaolin , Lu Xiaoyan , Li Mengfei , Li Fei
Published: May 2022

Grain production space, ecological service space and urban–rural development space are the classifications of land systems from the perspective of the dominant function of the land system. Grain production space reconstruction concentrates on the principal contradictions of land system changes, and is the key to exploring the transformation of land system. Therefore, the pathways, process and influencing factors of grain production space reconstruction in the Loess Plateau of Chian from 1980 to 2018 was explored from three dimensions of quantity–quality–spatial pattern in this study. Results showed that the quantity of grain production space showed a slight downward trend with a net decrease of 9156 km2 between 1980 and 2018, but its total quality showed a fluctuating growth trend under rain-fed conditions. Due to the intensification of human activities, grain production space was gradually fragmented, and the distribution tended to be decentralized, and the shape gradually became regular. Meanwhile, both the quantity and quality gravity center of grain production space moved to the northwest by 8.32 km and 86.03 km, respectively. The reconstruction of grain production space in the Loess Plateau was mainly realized through four pathways: Grain for Green, Urban Expansion, Deforestation and Reclamation, and Land Consolidation. The grain production space was mainly reconstructed through the pathway of Grain for Green after 2000. The four reconstruction pathways were the result of a combination of natural environment and socio-economic factors, but influencing factors had different strengths and directions for each reconstruction pathway. From the perspective of social economy–land use–ecological environment coupling, in order to maintain the sustainable development of the land systems, it is necessary to reduce the trade-offs of the functions of land systems as much as possible and strive to coordinate the relationship among grain production, ecological protection and high-quality development.
Facebook Feeds and Child Feeding: A Qualitative Study of Thai Mothers in Online Child Feeding Support Groups
Authors: Supthanasup Abhirat , Banwell Cathy , Kelly Matthew
Published: May 2022

Mothers have traditionally sought child feeding information from social connections. While mothers are heavily engaged on social media and value peer support in online communities, very little is known about how they use online communities for information about child feeding practices after exclusive breastfeeding cessation. This study explores mothers’ perceptions of joining Facebook child feeding support groups. Individual semi-structured interviews with ten Thai mothers were conducted. The transcribed interviews were analyzed using a phenomenological hermeneutical approach. Our findings highlighted that Thai mothers participated in Facebook child feeding support groups in a deliberate effort to reduce their uncertainty by normalizing the process through accessing the shared experiences of others. One of their intentions was to seek menu recipes based on favorable psychosocial and environmental factors. Implications for using social media in health promotion and communication include the importance of building appropriate common practices through social collaboration and interactivity to supplement traditional knowledge and attitudes.
Emotions, Strategies, and Health: Examining the Impact of an Educational Program on Tanzanian Preschool Children
Authors: Kauffman Lauren E. , Dura Elizabeth A. , Borzekowski Dina L. G.
Published: May 2022

Around the world, well-produced television programming can engage vulnerable, hard-to-reach audiences by offering informal education and enrichment. Akili and Me is an animated children’s educational program available in Sub-Saharan Africa that provides age and culturally appropriate lessons. In 2018, the producers created socio-emotional and health content. This study examines the relationship between children’s exposure to the new Akili and Me content and socio-emotional and health outcomes. Participants included low-income school children (mean age 5.32 years, SD = 0.82) from Arusha, Tanzania. Researchers conducted one-on-one baseline and post-intervention surveys with each participant. Over 12 weeks, the children attended afterschool sessions with screenings of Akili and Me, with distinct content screened on different days. The research team recorded children’s attendance and assessed children’s receptivity to the program through character identification. Using MLM regression models with data from 411 participants from 10 public schools, the analyses showed that a greater exposure and receptivity to Akili and Me predicted improved outcomes scores on the socio-emotional and health outcomes, controlling for sex, age, baseline scores, and general media receptivity (non-Akili and Me characters). Contributing to the literature on educational media, this study shows that exposure to an animated program can teach vulnerable preschool children socio-emotional and health content.
Molecular Pathology of Skin Melanoma: Epidemiology, Differential Diagnostics, Prognosis and Therapy Prediction
Authors: Tímár József , Ladányi Andrea
Published: May 2022

Similar to other malignancies, TCGA network efforts identified the detailed genomic picture of skin melanoma, laying down the basis of molecular classification. On the other hand, genome-wide association studies discovered the genetic background of the hereditary melanomas and the susceptibility genes. These genetic studies helped to fine-tune the differential diagnostics of malignant melanocytic lesions, using either FISH tests or the myPath gene expression signature. Although the original genomic studies on skin melanoma were mostly based on primary tumors, data started to accumulate on the genetic diversity of the progressing disease. The prognostication of skin melanoma is still based on staging but can be completed with gene expression analysis (DecisionDx). Meanwhile, this genetic knowledge base of skin melanoma did not turn to the expected wide array of target therapies, except the BRAF inhibitors. The major breakthrough of melanoma therapy was the introduction of immune checkpoint inhibitors, which showed outstanding efficacy in skin melanoma, probably due to their high immunogenicity. Unfortunately, beyond BRAF, KIT mutations and tumor mutation burden, no clinically validated predictive markers exist in melanoma, although several promising biomarkers have been described, such as the expression of immune-related genes or mutations in the IFN-signaling pathway. After the initial success of either target or immunotherapies, sooner or later, relapses occur in the majority of patients, due to various induced genetic alterations, the diagnosis of which could be developed to novel predictive genetic markers.
Nanoarchitectonics for Biodegradable Superabsorbent Based on Carboxymethyl Starch and Chitosan Cross-Linked with Vanillin
Authors: Czarnecka Elżbieta , Nowaczyk Jacek , Prochoń Mirosława , Masek Anna
Published: May 2022

Due to the growing demand for sustainable hygiene products (that will exhibit biodegradability and compostability properties), the challenge of developing a superabsorbent polymer that absorbs significant amounts of liquid has been raised so that it can be used in the hygiene sector in the future. The work covers the study of the swelling and dehydration kinetics of hydrogels formed by grafting polymerization of carboxymethyl starch (CMS) and chitosan (Ch). Vanillin (Van) was used as the crosslinking agent. The swelling and dehydration kinetics of the polymers were measured in various solutes including deionized water buffers with pH from 1 to 12 and in aqueous solutions of sodium chloride at 298 and 311 K. The surface morphology and texture properties of the analyzed hydrogels were observed by scanning electron microscopy (SEM). The influence of this structure on swelling and dehydration is discussed. Fourier transform infrared (FTIR) analyses confirmed the interaction between the carboxymethyl starch carbonyl groups and the chitosan amino groups in the resulting hydrogels. Additionally, spectroscopic analyses confirmed the formation of acetal crosslink bridges including vanillin molecules. The chemical dynamics studies revealed that new hydrogel dehydration kinetics strongly depend on the vanillin content. The main significance of the study concerns the positive results of the survey for the new superabsorbent polymer material, coupling high fluid absorbance with biodegradability. The studies on biodegradability indicated that resulting materials show good environmental degradability characteristics and can be considered true biodegradable superabsorbent polymers.
Mediators of Regional Kidney Perfusion during Surgical Pneumo-Peritoneum Creation and the Risk of Acute Kidney Injury—A Review of Basic Physiology
Authors: Kopitkó Csaba , Medve László , Gondos Tibor , Soliman Karim Magdy Mohamed , Fülöp Tibor
Published: May 2022

Acute kidney injury (AKI), especially if recurring, represents a risk factor for future chronic kidney disease. In intensive care units, increased intra-abdominal pressure is well-recognized as a significant contributor to AKI. However, the importance of transiently increased intra-abdominal pressures procedures is less commonly appreciated during laparoscopic surgery, the use of which has rapidly increased over the last few decades. Unlike the well-known autoregulation of the renal cortical circulation, medulla perfusion is modulated via partially independent regulatory mechanisms and strongly impacted by changes in venous and lymphatic pressures. In our review paper, we will provide a comprehensive overview of this evolving topic, covering a broad range from basic pathophysiology up to and including current clinical relevance and examples. Key regulators of oxidative stress such as ischemia-reperfusion injury, the activation of inflammatory response and humoral changes interacting with procedural pneumo-peritoneum formation and AKI risk will be recounted. Moreover, we present an in-depth review of the interaction of pneumo-peritoneum formation with general anesthetic agents and animal models of congestive heart failure. A better understanding of the relationship between pneumo-peritoneum formation and renal perfusion will support basic and clinical research, leading to improved clinical care and collaboration among specialists.
Perinatal and Neonatal Outcomes in Fetal Growth Restriction and Small for Gestational Age
Authors: Lubrano Chiara , Taricco Emanuela , Coco Chiara , Di Domenico Fiorenza , Mandò Chiara , Cetin Irene
Published: May 2022

Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. In this retrospective study, we analyzed data of 906 pregnancies collected in our maternal fetal medicine center, with different patterns of growth: 655 AGA (Appropriate for Gestational Age), 62 SGA (Small for Gestational Age: fetuses born with a weight less than 10° centile, not diagnosed before delivery), 189 FGR (Fetal Growth Restriction, classified in early and late according to gestational week at diagnosis). For each group, we compared maternal characteristics, gestational age at delivery, and perinatal and neonatal outcomes. Risk factors for fetal growth alterations were advanced age, being primiparous, and a lower pregestational BMI. FGR fetuses were born at earlier gestational ages (32 [IQR 29–38] early-FGR and 38 [IQR 36–39] late-FGR), with blood gas values comparable to the AGA group but worse neonatal outcomes related to prematurity. Unexpected SGA fetuses born by vaginal delivery, managed as AGA, were more hyperlactacidemic (4.4 [IQR 2.7–5.5]) and hypoxemic (−5.0 [IQR −7.1–2.8]) at birth than both AGA and FGR. However, neonatal outcomes (accesses and days of hospitalization in NICU) were better than FGR, likely due to gestational age and birthweight similar to AGA.
The Key Role of Lifestyle Factors in Perpetuating Chronic Pain: Towards Precision Pain Medicine
Authors: Nijs Jo , Reis Felipe
Published: May 2022

Chronic pain has a massive personal and socioeconomic impact and remains a challenge for many clinicians around the world [...]
See Me, Feel Me, Touch Me, Heal Me: A Contextual Overview of Conductive Polymer Composites as Synthetic Human Skin
Authors: Snyder Douglas E. , Sapper Erik D.
Published: May 2022

The fields of polymer science, conductive composites, materials engineering, robotics, and human perception intersect at the development and application of synthetic human skin. To be accepted by human users, artificial human skin must meet several requirement benchmarks. Synthetic human skin must look realistic, but not be eerie or creepy, upsetting those using or interacting with the material. Synthetic skin must feel like human skin, including mechanical response, thermal conductivity, and tactile properties. Realistic synthetic human skin must be electrically conductive, so that the user may experience accurate sensations of touch and feel. Finally, synthetic human skin should possess some degree of self-healing behavior. This review provides a brief description of advances in these disparate aspects of synthetic skin science, from the perspective of a practicing conductive polymer composite scientist and engineer.