bluuebunny/crossref_metadata_2025 huggingface dataset:
Examination of the Attitudes of Nursing and Midwifery Students Receiving Distance Education during the COVID-19 Pandemic towards Mobile Learning
Authors: Kılıç Züleyha , Aydınlı Ayşe , Günaydın Yurdagül , Polat Sevinç
Published: October 2023

Objective: This descriptive study was conducted to determine the attitudes of nursing and midwifery students receiving distance education during the COVID-19 pandemic toward mobile learning.

Methods: The population of this study comprised 618 1st, 2nd, 3rd, and 4th year students enrolled in the Faculty of Health Sciences Department of Nursing and Midwifery. There was no sample selection and research was completed with 237 students who volunteered to participate in the study. A Questionnaire Form and the Mobile Learning Attitude Scale (MLAS) were used to collect data.

Results: The mean MLAS score of the female students was 58±11.5 and the mean score of male students was 58±16.0. There was no difference between the total scale and sub-scale scores concerning sex, age, department, and year of students (p>0.05). During the COVID-19 pandemic, students mostly used their smartphones to access the internet. The most significant advantage of M-learning was the ease of use and access; however, the disadvantage was that education was not efficient and effective. Moreover, the biggest difficulty experienced by students in M-learning during the COVID-19 pandemic was internet access and the associated cost. The majority of students who participated in this study felt that M-learning did not affect their academic achievements but was not suitable for nursing and midwifery students.

Conclusions: The attitudes of nursing and midwifery students toward M-learning during the COVID-19 pandemic were moderate.
Prevention of Skin Damage Caused by Medical Adhesive Removal in Premature Infants
Authors: Özsayın Asuman , Çetinkaya Bengü
Published: October 2023

Objective: The aim of this study is to assess the effectiveness of the use of silicone tape and the use of a protective hydrocolloid dressing under silk tape in preventing skin damage due to medical adhesive removal in premature infants.

Method: A randomized controlled trial was conducted with 75 premature infants between 32 and 36 weeks gestational age to examine the effects of the following medical adhesives used for fixing equipment on skin damage: protective hydrocolloid dressing + silk tape, silicone tape, and silk tape + silicone-based solvent spray. After medical adhesives were applied to the skin of the newborn for orogastric tube fixation, the skin condition was monitored for 24 hours. The skin condition was assessed with the Neonatal Skin Condition Scale before and after adhering to the medical adhesives. The statistical tool SPSS 22 was used to examine the study's data.

Results: Neonatal skin condition scores were highest in the silk tape + silicone-based solvent spray group, while the lowest score was found in the silicone tape group. A statistically significant, moderate correlation, with a negative direction, was found between birth weight and post-application skin condition scores (r = -.432, p
COVID-19 Pandemi Döneminde Hemşirelik Öğrencilerinin Hijyen Davranışlarının İncelenmesi
Authors: Erden Yasemin , Doğan Sevgi , İpekçoban Gülay
Published: October 2023

Amaç: Araştırma, COVID-19 pandemi döneminde hemşirelik öğrencilerinin hijyen davranışlarını belirlemek amacıyla yapılmıştır.

Yöntem: Tanımlayıcı tipte yapılan araştırmanın evrenini, 2020-2021 eğitim-öğretim döneminde, Türkiye’nin doğusunda yer alan bir üniversitenin hemşirelik bölümünde eğitim gören 1106 öğrenci oluşturmuştur. Örneklemi ise araştırmaya katılmayı kabul eden 448 öğrenci oluşturmuştur. Veriler, demografik özellikleri içeren “Tanımlayıcı Form” ve hijyene yönelik soruları içeren “Hijyen Davranışları Ölçeğinden” yararlanılarak toplanmıştır. Verilerin değerlendirilmesinde tanımlayıcı istatistiksel yöntemler (Yüzde, Ortalama, Standart Sapma), Mann Whitney U testi, t testi, Kruskal Wallis kullanılmıştır.

Bulgular: Çalışmada yer alan öğrencilerin %85.3’ ü 18-21 yaş aralığında olup %75’i kadındır. Öğrencilerin ölçek puan ortalamalarının kişisel hijyen alt boyutunda 22.13±4.07, el yıkama alt boyutunda 9.08±2.07, gıda hijyeni alt boyutunda 8.47±2.06 olduğu belirlenmiştir. Hijyen Davranışları Ölçeği toplam puan ortalamaları ise 39.69±6.69 olarak saptanmıştır.

Sonuç: Araştırma sonucunda hemşirelik öğrencilerinin pandemi döneminde hijyen davranışlarının olumsuz olduğu, sadece gıda hijyeni alt boyutunda olumlu hijyen davranışına sahip oldukları belirlenmiştir. Araştırma sonuçları doğrultusunda, pandemi döneminde hemşirelik öğrencilerinin hijyen davranışlarına yönelik inanç ve uygulamalarının daha kapsamlı araştırmalarla değerlendirilmesi, konuyla ilgili eğitimsel çalışmaların yapılması önerilir.
İnfertilite Tanısı Olan Bir Kadına Neuman Sistemler Modeli Doğrultusunda Uygulanan Hemşirelik Bakımı: Olgu Sunumu
Authors: Özkan Şat Sultan , Yaman Sözbir Şengül
Published: October 2023

Bu çalışmanın amacı, infertilite tanısı olan bir kadına Neuman Sistemler Modeli doğrultusunda uygulanan hemşirelik bakımının açıklanmasıdır. Bu çalışma bir olgu sunumudur. Çalışmanın verileri ve olgunun hemşirelik bakımı katılımcı ile üç kez derinlemesine görüşme yapılarak uygulanmıştır. Görüşmeler esnasında Neuman Sistemler Modeli’ne uygun olarak Neuman tarafından geliştirilmiş yarı yapılandırılmış soru yönergesi kullanılmıştır. Çalışmada yer alan kadın hasta, mahremiyetinin korunması amacıyla “Gizem” ismiyle kodlanmıştır. Bulgularımız Gizem Hanım’ın fizyolojik, psikolojik, sosyokültürel, gelişimsel ve spiritüel alanlarında kişi içi, kişilerarası ve kişi dışı stresörlerinin olduğunu; en çok psikolojik, sosyokültürel ve gelişimsel alanlarda stres yaşadığını ortaya çıkarmıştır. Gizem Hanım’ın algıladığı stresörlere yönelik esnek savunma hattının aktive olduğu, ancak kullandığı baş etmelerin etkisiz ve sınırlı baş etme yöntemleri olması nedeniyle sorunun çözülemediği belirlenmiştir. Sorunun çözülememesi nedeniyle stresörlerin normal savunma hattına giriş yaptığı ve sistemde temel yanıt tepkisinin ortaya çıktığı belirlenmiştir. Bu nedenle Gizem Hanım’a ikincil ve üçüncül koruma kapsamında belirlenen hemşirelik girişimleri uygulanmıştır. Neuman Sistemler Modelinin; infertilite sorunu yaşayan hastaların deneyimledikleri stresi ve stresle baş etmelerini belirlemede çok boyutlu bir çerçeve sağladığı, sorunların çözümünde bütüncül bir yaklaşım sunduğu düşünülmektedir. Bu nedenle, toplumsal bir olgu olan ve hem kadını hem erkeği her anlamda oldukça fazla etkileyen infertilite problemine bağlı yaşanan sorunların olabildiğince hızlı bir şekilde tanımlanması ve çözümüne yönelik etkili müdahalelerin geliştirilmesi açısından Neuman Sistemler Modeli’nin infertilite hastalarına bakım veren hemşireler tarafından kullanılmasının önemli olduğu düşünülmektedir.
Kaposi Sarkomu Nedeniyle Hematoloji Kliniğinde Yatan HIV (+) Hastanın Orem’in Öz Bakım Eksikliği Kuramına Göre Hemşirelik Yönetimi: Olgu Sunumu
Authors: Eraslan Dilek , Akyol Asiye
Published: October 2023

The World Health Organization reported that 38.4 million people were living with HIV in 2021 and 650 thousand people lost their lives due to HIV and viruses. Kaposi's sarcoma is still one of the most common cancers in HIV-infected people. Individuals living with this disease also have many biological, psychological and social needs. The aim of this article is to determine the needs of a young patient with Kaposi's sarcoma who has just been diagnosed with HIV (+) according to Orem Self-Care Deficit Nursing Theory, to perform nursing care and to guide nurses working in the field. Data were collected by face-to-face interviews in the hematology clinic, care was planned, applied and evaluated according to the model. As a result of the theoretical evaluation of the case, the nursing diagnoses of "impaired gas exchange, activity intolerance, excess fluid volume, anxiety, deterioration in body image, lack of knowledge, risk of infection, and deterioration of the oral mucous membrane" were determined. Orem Self-Care Deficit Nursing Theory is a useful model for determining the needs of HIV-positive patients and in the implementation of nursing interventions.
Hibrit Eğitim Alan Hemşirelik Öğrencilerinin Pandemi Sürecinde Klinik Uygulama Kaygısı ve Özyeterlik İnançlarıyla İlişkisi: Kesitsel Bir Çalışma
Authors: Takmak Şenay , Karaçar Yeliz
Published: October 2023

Amaç: Bu çalışmada hibrit eğitim alan hemşirelik öğrencilerinin COVID-19 pandemisi sırasındaki ilk klinik deneyimleri öncesi ve sonrasında anksiyete ve öz yeterliklerinin incelenmesi amaçlanmıştır.
Yöntem: Bu çalışma Kasım-Aralık 2021 tarihleri arasında bir devlet üniversitesinde kesitsel desende gerçekleştirilmiştir. Çalışmanın örneklemini ilk kez klinik uygulamaya başlayan 106 öğrenci oluşturmuştur. Araştırma verileri, klinik uygulamanın ilk ve son haftasında "Durumluk-Sürekli Kaygı Ölçeği" ve "Genel Öz Yeterlik Ölçeği" ile çevrimiçi anket yöntemiyle toplanmıştır. Verilerin analizinde Wilcoxon İşaretli Sıralar Testi, Kruskall Wallis Testi, Mann Withney U Testi ve Spearman korelasyon analizi kullanılmıştır.
Bulgular: Hibrit eğitim alan hemşirelik öğrencilerinin klinik uygulamanın ilk haftasında anksiyete ve öz yeterliklerinin orta düzeyde olduğu ve klinik uygulama sonunda durumluk anksiyetelerinin azalmadığı (p>0.05); ancak genel öz yeterlikleri ile dayanıklılık ve sürdürme alt boyut puanlarının azaldığı (sırasıyla p=.024, p=.002, p=.000) belirlenmiştir. Bu çalışmada öz yeterlik ve akademik başarı değişkenleri ile durumluk kaygı değişkeni arasında negatif ilişki bulunmuştur. Bununla birlikte kız öğrencilerin klinik uygulamanın başında daha yüksek öz yeterliğe sahip olduğu saptanmıştır (p=.001).
Sonuç: COVID-19 pandemisinde hemşirelik öğrencilerinin ilk klinik uygulamada anksiyeteleri orta düzeydeydi ve öz yeterlik algıları azaldı. Özellikle ilk klinik uygulamasına çıkan hemşirelik öğrencilerinde anksiyeteyi azaltıcı ve öz yeterlik algısını geliştirici eğitim ve uygulamaların klinik ve üniversite iş birliği ile yürütülmesi önerilmektedir.
Hemşire Öğrencilerin Afete Müdahale Öz Yeterliliğinin Değerlendirilmesi: Tanımlayıcı ve Kesitsel Çalışma
Authors: Durmuş Sarıkahya Selma , Yorulmaz Deniz S.
Published: October 2023

Amaç: Bu çalışma hemşirelik öğrencilerinin afete müdahale öz yeterliği ve etkileyen faktörleri değerlendirmek amacıyla gerçekleştirildi.

Yöntem: Tanımlayıcı tipte tasarlanan araştırmanın evrenini, bir devlet üniversitesinde öğrenim gören 3 ve 4. sınıf hemşirelik öğrencileri oluşturdu. Veriler 10-15 Ocak 2023 tarihleri arasında yüz yüze toplandı. Veri toplama aracı olarak “Sosyo-demografik Bilgi Formu” ve “Afete Müdahale Özyeterlik Ölçeği” kullanıldı.

Bulgular: Öğrencilerin %65.5’i kadın, %57.1’i 4. sınıfta öğrenim görmekte olup; %53.7’si daha önce herhangi bir afet deneyimlemiştir. Öğrencilerin %63.3’ünün afetler ile ilgili ders almadığı, %21.5’inin acil durum ve afet çantası içeriği hakkında ve %19.8’inin triyaj uygulaması hakkında bilgi sahibi olmadığı belirlendi. Erkek cinsiyet ve afetlere maruz kalma durumlarının afete müdahale yeterliliğinin belirleyicileri olduğu ve bu değişkenlerin ölçek puanının %14’ünü yordadığı saptandı.

Sonuç: Hemşire öğrencilerin afete müdahale yeterliliğinin istenilen düzeyde olmadığı ve afetlere hazırlıklarının yetersiz olduğu belirlendi. Hemşirelerin afetlere hazırlık, müdahale ve iyileşme dönemindeki yeri ve önemi dikkate alındığında, afetler konusunda bilgilendirmelerin yapılması, tatbikatların düzenlenmesi ve toplum katılımı ile yapılan etkinliklerin artırılması önerilmektedir.
New Business Models for Society 5.0
Authors: Ferebee Susan Shepherd , Lessen Nicholas
Published: November 2023

In the evolving landscape of technological advancements, the Internet of Behavior (IoB) emerges as a pivotal concept, harnessing the power of data to understand and influence humans. IoB finds its most profound application in Society 5.0, a vision of a super-smart society where digital and physical realms harmoniously coexist. New business and economic models like the circular economy, sharing economy, smart cities, platform business model, social enterprise model, and blockchain technology will be explored. Emerging healthcare, agriculture, hospitality, and energy business models are discussed. Challenges arise as innovative organizations emerge to create a more sustainable and inclusive culture. Data privacy and security, blockchain high energy consumption, technologically unprepared workforce, and artificial intelligence bias must be addressed. This chapter aims to demonstrate emerging economies, business models, and related technologies that facilitate Society 5.0 as it evolves from human behavior insights gained from IoB.
Stealth Assessments' Technical Architecture
Authors: Rahimi Seyedahmad , Almond Russell G. , Shute Valerie J.
Published: November 2023

With advances in technology and the learning and assessment sciences, educators can develop learning environments that can accurately and engagingly assess and improve learners' knowledge, skills, and other attributes via stealth assessment. Such learning environments use real-time estimates of learners' competency levels to adapt activities to a learner's ability level or provide personalized learning supports. To make stealth assessment possible, various technical components need to work together. The purpose of this chapter is to describe an example architecture that supports stealth assessment. Toward that end, the authors describe the requirements for both the game engine/server and the assessment engine/server, how these two systems should communicate with each other, and conclude with a discussion on the technical lessons learned from about a decade of work developing and testing a stealth-assessment game called Physics Playground.
Evaluating an Elevated Signal-to-Noise Ratio in EEG Emotion Recognition
Authors: Estreito Zachary , Le Vinh , Harris Jr. Frederick C. , Dascalu Sergiu M.
Published: November 2023

Predicting valence and arousal values from EEG signals has been a steadfast research topic within the field of affective computing or emotional AI. Although numerous valid techniques to predict valence and arousal values from EEG signals have been established and verified, the EEG data collection process itself is relatively undocumented. This creates an artificial learning curve for new researchers seeking to incorporate EEGs within their research workflow. In this article, a study is presented that illustrates the importance of a strict EEG data collection process for EEG affective computing studies. The work was evaluated by first validating the effectiveness of a machine learning prediction model on the DREAMER dataset, then showcasing the lack of effectiveness of the same machine learning prediction model on cursorily obtained EEG data.
The Cytotoxicity of 27-Hydroxycholesterol in MCF-7 and MDA-MB-231
Authors: Rashidi Alavijeh Mehran , Etesami Hossein , Dehghan Amin , Babajani Amirhesam , Haghjooy Javanmard Shaghayegh
Published: November 2023

Background:

Although several roles of 27-hydroxycholesterol (27-HC), the most abundant oxysterol in blood circulation, in cancers have been elucidated, its impact on breast cancer proliferation and its pathway remain unknown.

Materials and Methods:

The effect of 27-HC on breast cancer cell proliferation and its pathway was evaluated using Michigan Cancer Foundation - 7 (MCF-7) and M.D. Anderson - Metastatic Breast 231 (MDA-MB-231) cell lines. The MTT assay was applied after 24- and 48-hour incubation to distinguish cell proliferation. To determine the cause of different viability results from the MTT assay, the Annexin-FITC/PI test was used at concentrations of 0.1, 1, and 10 μM after 24- and 48-hour incubation.

Results:

27-HC in concentrations of 5, 10, and 20 μM induced cell cytotoxicity compared with control. Also, the annexin V conjugated with fluorescein isothiocyanate/propidium iodide (Annexin-FITC/PI) test revealed an increase in total apoptotic cells treated with 0.1, 1, and 10 μM of 27-HC after 48 hours (P value < 0.05). Besides, the cytotoxic effect of 27-HC was observed at 10 μM concentration in both cell lines, MCF-7 and MDA-MB-231 (P value < 0.05).

Conclusion:

The identification of 27-HC’s cytotoxic effects on both estrogen receptor (ER)-negative and ER-positive breast cancer cell lines is a novel discovery that may be linked to LXRβ.
Interesting Case of Esophageal Perforation Due to Foreign Body
Authors: Bhawarlal Padam Kumar , Murugaiyan Gnanasekar , Raj Saravana Krishna , Venkataraman Mohan , Gopalakrishnan  , Thirukonda Jeykumar , Ravichandran Pranesh
Published: November 2023

A 75 year old gentleman, who is a chronic heavy smoker and edentulous person who used to swallow his food rather than proper mastication, presented with chest pain and dysphagia. CT scan revealed foreign body penetrating the oesophagus and invading the mediastinum leading to a mediastinal collection. Upper gastrointestinal endoscopy to remove the foreign body was not successful, and hence open surgery was done by specialist in thoracic and surgical Gastroenterology. The foreign body was removed successfully and treated with appropriate antibiotics. Patient was discharged home as per plan and followed up in out patient clinic. He has been keeping well.
All that Glitters is not Gold
Authors: Viswanathan Vinod Kumar
Published: November 2023

In the midst of COVID pandemic, all cases presenting with lung infiltrates are assumed to be covid. However, other diagnoses are possible and a case of allergic bronchopulmonary aspergillosis which presented in the midst of the pandemic is highlighted here to stress the importance of clinical judgment by history taking, clinical examination, appropriate investigations, and treatment.
Mycobacterium genavense Causing Lung Abscess in an Immunocompetent Individual
Authors: Lawrence Ria , Narasimhan R
Published: November 2023

Mycobacterium genavense is a rare nontuberculous mycobacterium, known to cause serious infections in HIV-infected patients and immunocompromised individuals. The diagnosis of M. genavense is challenging because of its slow-growing nature in the routine acid-fast culture methods. Here, we present the case of lung abscess caused by M. genavense in an immunocompetent individual.
Kreativer Politikunterricht
Authors: Janssen Bernd
Published: October 2023

Der Autor zeigt kreative Methoden auf, um Politikstunden abwechslungsreich, und schüleraktivierend zu gestalten, ohne notwendige fachliche Lernziele aus den Augen zu verlieren. Mithilfe von exemplarischen Stundenentwürfen für den Inhaltsbereich „Diskriminierung und Rassismus“ wird z. B. die Anwendbarkeit der folgenden Methoden verdeutlicht: Enträtselung einer Quelle, Standbild, Sprechmühle, fiktives Interview, Spinnweb-Analyse, Ich-Texte, Perspektivenwechsel, Phantasiereise, 2-Minuten-Rede, Schreibgespräch, Identifikationskreis, Redekette, außerdem drei neue Methoden: Gruppenstreitgespräch, Schneeballverfahren und Motorinspektion.
Die Vorbereitung und Durchführung dieser Methoden erfordern wenig Zeit, sie können in 45-Minuten-Stunden problemlos eingesetzt werden, verbessern das Lernklima und fördern eine intensive Auseinandersetzung mit politischen Themen.
PISCICULTURA NA UNIVERSIDADE DE SÃO PAULO (CAMPUS DE PIRASSUNUNGA): UMA HISTÓRIA QUE NÃO FOI CONTADA
Authors: Albuquerque Ricardo , Ferraz José Apolinário , Barbosa José Milton
Published: October 2023

The aim of this paper is to recount the history of the first Fish Farming Station at the University of São Paulo (USP), Pirassununga Campus, an important instrument for consolidating aquaculture at the institution and for training specialized professionals, many of whom currently work in public and in the private sectors. The station was conceived during the administration of the Centre for Zootechnics and Livestock Industries Fernando Costa-Cizip, beginning the construction at the end of 1992, using the structure of the newly created of Pirassununga’s Campus, and was completed the following year, with the inauguration scheduled for August 1993, by the then rector of University of São Paulo. However, the Rector resigned his post eve of the inauguration, so the station was never formally inaugurated and its history was lost in the time.
The interaction studies of novel diaminophenazine gold(III) complex and Bovine Serum Albumin (BSA-ibuprofen and BSA-Eozine Y)
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Kesić Ana S. , Radisavljević Snežana R. ,   University of Kragujevac, Faculty of Science, Department of Chemistry, Serbia, Bogojeski Jovana V. ,   University of Kragujevac, Faculty of Science, Department of Chemistry, Serbia, Petrović Biljana V. ,   University of Kragujevac, Faculty of Science, Department of Chemistry, Serbia
Published: October 2023

It is well known that gold(III) complexes have found applications in medicinal inorganic chemistry. Considering this, the right choice of inert ligands in the structure of Au(III) complexes is crucial for predicting their properties and reactivity, especially towards biomolecules. Here are presented the results of the study of the interactions between the new gold(III) complex [Au(DAP)Cl3], with 2,3-diaminophenazine (DAP) as an inert ligand, and BSA. Specifically, serum albumin is the main soluble protein in the circulatory system of humans. The metabolism of drugs, their distribution, free concentration, and effectiveness strongly depend on the drug-albumin interaction. Investigation of the interactions of the [Au(DAP)Cl3] complex with bovine serum albumin (BSA) under physiological conditions was performed by fluorescence spectroscopy. This method was also used to identify the binding site on the BSA molecule, with eosin Y as a marker for site I (subdomain IIA), and ibuprofen as a marker for site II (subdomain IIIA). The results have shown that the complex moderately reacts with the BSA molecule with just one binding site for the complex on the protein. Additionally, based on the results with site markers, especially with eosin Y, it can be concluded that the studied complex binds to site I of the BSA molecule.
The influence of structural modification of Pd(II) pincer-type complexes on the kinetics of substitution reactions
Authors:   University of Kragujevac, Faculty of medical science, Department of pharmacy, Serbia, Jovanović Stević Snežana , Radisavljević Snežana , Mijatović Aleksandar ,   University of Belgrade, Faculty of mining and geology, Serbia, Petrović Biljana ,   University of Kragujevac, Faculty of science, Serbia, Kesić Ana ,   University of Kragujevac, Institute for information technologies, Serbia
Published: October 2023

This mini-review summarizes the kinetic data obtained for the substitution reactions of some palladium(II) complexes containing bis-pyrazolylpyridine derivatives as pincer-type ligands with biologically significant nitrogen- and sulfur-donor biomolecules as nucleophiles. Three structurally different palladium(II) complexes were selected: [Pd(L1)Cl]+(Pd1), [Pd(L2)Cl]+(Pd2) and [Pd(L3)Cl]+(Pd3) (where L1 = bis(2-(1H-pyrazol-1-yl)ethyl)amine, L2 = 2,6-bis(5-(tert-butyl)-1H-pyrazol-3-yl)pyridine, and L3 = 2,6-bis(5-(tert-butyl)-1-methyl-1H-pyrazol-3-yl)pyridine, while for the entering nucleophiles thiourea (Tu), L-methionine (L-met), and guanosine-5’-monophosphate (5’-GMP) were used. Kinetic measurements were carried out for all systems as pseudo-first order reactions (at least 10 times the ligand in excess relative to the complex) under physiological conditions using a stopped-flow UV-Vis spectrophotometer. By comparing the published results for the second-order rate constant, the relationship between the structural properties of the complexes and their reactivity towards selected nucleophiles was established. This overview shows that by tuning the lability of the inert ligands through steric and electronic (σ-donor and π-acceptor) effects, the biological behavior of the complexes can be significantly changed.
In vitro cytotoxic activity of a monolacunary Wells-Dawson nanocluster against cervical carcinoma HeLa cells
Authors:   University of Belgrade, “Vinča” Institute of Nuclear Sciences-National Institute of thе Republic of Serbia, Čolović Mirjana B. , Žakula Jelena J. ,   University of Belgrade, “Vinča” Institute of Nuclear Sciences-National Institute of thе Republic of Serbia, Department of Molecular Biology and Endocrinology, Korićanac Lela B. ,   University of Belgrade, “Vinča” Institute of Nuclear Sciences-National Institute of thе Republic of Serbia, Department of Molecular Biology and Endocrinology, Savić Nada ,   KU Leuven, Department of Chemistry, Belgium, Parac-Vogt Tatjana ,   KU Leuven, Department of Chemistry, Belgium, Krstić Danijela Z. ,   University of Belgrade, Faculty of Medicine, Institute of Medical Chemistry, Serbia
Published: October 2023

The aim of this study was to assess in vitro cytotoxic activity of a monolacunary Wells-Dawson nanocluster, α2-K10P2W17O61.20H2O (lacunary WD) against cervical carcinoma HeLa cells as a commonly used model system for the evaluation of antitumor properties. After HeLa cells had been exposed to the investigated polyoxotungstate (the concentration range of 0.001 – 1 mM) for 24, 48, and 72 h, relative cell viability (expressed as a percentage of control) was determined. The obtained results showed that lacunary WD affected HeLa cell viability in a concentration-and time-dependent manner. IC50 values (in μM), calculated using sigmoidal fitting experimental plots, were as follows: 24.11 ± 9.95, 12.74 ± 0.096, and 11.48 ± 0.12 for 24, 48, and 72 hours treatment, respectively. In comparison with cisplatin, (positive control), IC50 values (μM) for 24 hours treatment were similar – 24.11 (lacunary WD) vs. 24.49 (cisplatin). However, after 48 and 72 hours IC50 obtained for cisplatin were found to be lower – 8.81 and 4.93 μM, respectively. Accordingly, the studied WD polyoxotungstate could not be regarded as a superior anticancer agent in comparison with the standard chemotherapeutic. Nevertheless, this studied nanocluster deserves attention as a promising antitumor therapeutic and as a good platform for the design of next-generation metal-based anticancer agents.
Theoretical and experimental study of bilastine ionization
Authors:   University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Serbia, Popović-Nikolić Marija R. , Popović Gordana ,   University of Belgrade, Faculty of Pharmacy, Department of General and Inorganic Chemistry, Serbia, Oljačić Slavica ,   University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Serbia, Nikolić Katarina ,   University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Serbia
Published: October 2023

The protolytic equilibria of bilastine were studied experimentally and theoretically. The pKa values were determined potentiometrically at a constant ionic strength (0.1 M NaCl) and temperature 25 °C. Energy calculation of the optimized structures of the equilibrium forms was performed at the B3LYP/6-31G (d,p) level of the Density Functional Theory (DFT). The results of the theoretical study helped to define the ionization profile of bilastine and to assign the experimentally determined pKa values to the corresponding ionizable groups.
Levels Of Interleukin-1Beta, Interleukin-8 And Sialidase Vaginal Smears Of Pregnant Women With Bacterial Vaginosis As Predictors Of Treatment Failure With Metronidazole
Authors: Raka Budayasa A.A. Gede , Rajani A.A. Puteri Indira , Satyarini A.A. Puteri Litha
Published: October 2023

Bacterial vaginosis is a health problem of pregnant women, due to  its increased  prevalence, and increased maternal and perinatal morbidity and mortality,   especially its relationship with preterm labor. There is a decrease in recovery with standard treatment of metronidazole. To date there has been no map to predict treatment failure. Maternal immune response factors and germ virulence factors are expected to be used as a high-risk case of treatment failure. This study intends to determine whether the levels of interleukin-1?, interleukin-8 and sialidase in vaginal smears of pregnant women against the risk can be used as predictors of failure of treatment of pregnant women with BV with Mtronidazol.   This study used an observational case control study design.  The case group was single pregnant women living with a gestational age of less than 20 weeks with BV infection who had failure treatment with metronidazole and the control group was pregnant women with BV infection who recovered with metronidazole treatment. The research was conducted at the Obstetrics Polyclinic of Sanjiwani Hospital. The study material was taken from the vaginal smear of pregnant women with BV and an elisa examination was carried out to determine the level of interleukin-1? In this study, 26 pregnant women were found as cases of treatment failure and 26 pregnant women as controls. There were no differences in the average maternal age, gestational age and parity between cases and controls. There were significant differences in mean IL-1? levels (p = 0.004), IL-8 levels (p = 0.013) and sialidase (p =  0.008), in the case group compared to controls.  The cutoff of IL-1?, IL-8 and sialidase levels as predictors of treatment failure was 1401.17 ng/dl, 329.02 ng/dl and 2.38 ng/dl, respectively. Based on the results of the study above, cutoffs of IL-1?,  IL-8 and sialidase levels as predictors of treatment failure were 1401.17 ng / dl, 329.02 ng / dl and 2.38 ng / dl, respectively. Further research is needed to determine the influence of high levels as a risk factor for treatment failure.
Kars İlinde Arıcılık İşletmelerinin Sosyo-Ekonomik Yapısı Üzerine Bir Araştırma
Authors: VARALAN Alperen , ÇEVRİMLİ Mustafa Bahadır
Published: November 2023

Bu araştırma, Kars ilinde faaliyette bulunan Türkiye Arı Yetiştiricileri Merkez Birliği’ne üye işletmelerin sosyal ve ekonomik durumun incelenmesi ve değerlendirilmesi amacı ile yapılmıştır. Çalışmanın materyalini, ili temsil edecek şekilde seçilen toplam 70 adet arıcılık işletme sahibi ile yüz yüze yapılan anketlerden elde edilen veriler oluşturmuştur. Çalışma sonucunda arıcılık işletme sahiplerinin yaş ortalamasının 50.91 ± 8.95 olduğu, %38.57 oranla lise mezunu olduğu, %27.14’ünün ise üniversite mezunu olduğu görülmüştür. İşletme sahiplerinin %65.71’i arıcılıkla birlikte tarım ve hayvancılık harici bir sektörden gelir elde ettiklerini belirtmişlerdir. Çalışmaya konu işletmelerdeki kovan ortalaması 166.8 (≌ 167) adet olarak bulunmuştur. Anket yapılan işletme sahiplerinin genel gelirlerinin 160 685.71 ± 21 483.14 TL olduğu tespit edilmiştir.
Keanekaragaman Echindodermata Berdasarkan Tipe Substrat Di Pulau Tidung Kepulauan Seribu
Authors: Andriyani Fitri , Muhammad Saiful  , Nada Syifa Azahra  , Safina Zahira  , Rindy Serlina  , Rusdi
Published: October 2023

The purpose of this study was to determine the biodiversity of Echinodermata on Tidung island. This study was conducted on February 2019 using purposive sampling method. Data collection was performed using belt transect method and data were analyzed quantitatively by calculating Echinoderm’s abundance relativity index and species diversity index and compare the data on each substrate. Based on observations of Echinoderms species diversity on Tidung island, belongs to low to moderate level with a value of 0.8269 - 1.0057 and abundance is mostly found at station 2 with a value of 52.5%, of Ophiomastix sp. totaled 21 individuals and salinity at station 2 was 28%
Penerapan Metode Pembobotan ROC Dan Metode WASPAS Pada Sistem Pendukung Keputusan Seleksi Pemilihan Penerima Bantuan UKT
Authors: Utomo Dito Putro , Ginting Guidio Leonarde
Published: October 2023

The impact of the Covid-19 pandemic that is felt by the community is the paralysis of all daily activities. As a result, the cessation of work for a long time causes the company's economy to cripple and results in many companies losing money and making Termination of Employment (PHK) for employees or employees. For the heads of families, the termination of employment (PHK) experienced, of course, has a fairly heavy impact. There are many bad impacts caused by Termination of Employment (PHK) such as not being able to continue education for children, especially in college due to not being able to pay tuition fees every semester. Therefore, to overcome this problem, the government created a Single Tuition Assistance (UKT) program. However, the UKT assistance provided by the government was not able to cover all the financing needs for students who were affected by the Covid-19 pandemic. Limiting quotas for recipients of Resident Tuition (UKT) assistance for Budi Darma University is a new problem, of course. Decision Support System is a computerized system on a computer that is used to support decision making in organizations. The Weighted Aggregated Sum Product Assessment (WASPAS) method is a combined method consisting of the WP method and the SAW method, the WASPAS method is expected to provide better results in helping to determine the decision support system. To support obtaining optimal and objective results, a weighting method is needed, namely the ROC method. Based on the above discussion, the research that will be carried out is to select students who receive Single Tuition (UKT) assistance. The results showed that the four alternatives with the highest preference scores received UKT assistance, namely A6, A5, A4, A3
Penerapan Kombinasi Metode ROC dan TOPSIS Pemilihan Karyawan Terbaik Untuk Rekomendasi Promosi Jabatan
Authors: Sianturi Lince Tomoria , Mesran Mesran
Published: October 2023

Position promotion is a transfer or promotion of an employee in a structure within the organizational structure who has the ability to know skills and a responsible attitude in accordance with qualifications based on standards that exist in a company itself with specific functions. In the process of selecting the best employees, for recommendation for promotion, a measurable decision support system is needed. As in the POLDASU HR BUREAU, which does not yet have a decision support system, which so far has recommended promotions at the North Sumatra Regional Police, there are still obstacles in the criteria for evaluating promotions, so does not rule out the possibility that decision making is done subjectively by only looking at certain aspects and requires a long time in making decisions. In general, the recommendation for promotion is given by each work unit, good assessments from superiors and employee performance in carrying out their duties. For this reason, it is necessary to assess data processing employees who can help companies make decisions related to promotion recommendations. There needs to be supporting criteria for using a decision support system. In this study applied a combination of ROC and TOPSIS methods. The weighting of each criterion is carried out by applying the ROC method, then followed by a ranking process that will select the best alternative from a number of alternatives using the TOPSIS method. The TOPSIS method is a method that uses the principle that the chosen alternative must have the closest distance from the positive ideal solution and the farthest from the negative ideal solution. The results of the Research Recommendations for Promotion of Positions that are appropriate for promotion are alternative A1 with a preference value of 1,497 on behalf of "Hendrik".
Sistem Pendukung Keputusan Menentukan Kelayakan Lahan Pembibitan Menggunakan Metode Multi Attribute Utility Theory
Authors: Hutagalung Juniar , Nasyuha Asyahri Hadi , Pradita Titin
Published: October 2023

Determining the location of plantation land is a very important role to support the development of oil palm plantations and also factors that support plantations to produce oil palm fruit with good quality. To help companies produce palm oil with the best quality fruit, it is necessary to have the appropriateness of the land used for oil palm planting from the seedling process. PT. Fajar Agung experienced several difficulties in making a decision to choose suitable land for oil palm seedlings, so making a decision took a long time. In determining the feasibility of oil palm nurseries, a decision support system is needed by applying the Multi Attribute Utility Theory (MAUT) method. The purpose of this study is to implement a decision support system in determining the feasibility of oil palm nurseries using the Multi Attribute Utility Theory (MAUT) method to be more effective and efficient for the leadership in making a decision so that the company does not suffer losses. From the calculation results to be used as an oil palm nursery with an assessment that is more than 0.500 which is declared feasible there are 6 alternatives, namely A5 (Block 5), A6 (Block 6), A7 (Block 7), A8 (Block 8), A11 (Block 7A ) and A1 (Block 1) with the highest score of 0.838. MAUT method can be used as an alternative method to perform calculations based on predetermined criteria so as to facilitate decision making.
Penerapan Metode Naive Bayes Dalam Rekomendasi Strategi Penerimaan Peserta Didik Baru
Authors: Sani Afan Hafara , Setiawan Agus , Primadewi Ardhin
Published: October 2023

New Student Admission (PPDB) is a school spearheading activity in getting students, especially for private schools. SMK Muhammadiyah 1 Borobudur as one of the private vocational schools in Magelang Regency. SMK Muhammadiyah 1 Borobudur has problems related to the PPDB promotion strategy. The PPDB promotion that has been carried out has not fully shown a significant promotion growth to increase the number of students registering each year and PPDB information has not yet reached remote areas of Magelang Regency. In determining the promotion media for PPDB SMK Muhammadiyah 1 Borobudur, this study uses the Naïve Bayes algorithm. Naïve Bayes is a classification method using probability and statistics to predict future opportunities based on the past. By using the nave Bayes algorithm which is applied with a ratio of 70:30 for train data and test data, it is able to produce an accuracy of 72%. To maximize the results of data accuracy, this study used the k-fold cross-validation method with k=10 times resulting in an accuracy of 75%. In addition, it can be seen that 3 PPDB information is recommended for promotional media, namely student partners, alumni and Instagram.
Penerapan Metode Posenet untuk Deteksi Ketepatan Pose Yoga
Authors: Ahmad Asshidiqy Raynaldi , Setiawan Agus , Sasongko Dimas
Published: October 2023

When someone does yoga activities, usually, someone follows yoga guidelines in the form of yoga classes and yoga self-guidance, which is usually in the form of images, videos, and audio. But along with the rapid development of technology, now there are many yoga guides and easy to get. Yoga activities can now be done independently without approaching a yoga instructor. The purpose of this study is to help yogis to be able to do yoga correctly and to follow yoga guidelines with the correct poses with a system that contains yoga poses and also as the main feature of correcting yoga poses that yogis do to get yoga poses correctly. The resulting system will capture yoga poses and detect whether the pose is correct according to the yoga pose guidelines. Based on the verification of the distance between the device or the device that has a camera, it is placed at a distance of 200cm – 250cm between the device and the yogis. The device's height is placed in a place that has a height half the size of the yogi's whole body or at the height of 85cm. The test results using the BlackBox method get no errors. Besides that, the system can run well in a room with 7-watt LED lights, and no objects block the yogis, so the camera catches the whole body.
Penerapan Algoritma Advanced Encryption Standard (AES) Untuk Keamanan Data Transaksi Pada Sistem E-Marketplace
Authors: Andriyanto Muhammad Riyan , Sukmasetya Pristi
Published: October 2023

Sriwedari Village known as a producer of superior plant seeds and fruits in the Salaman District area. The Sriwedari Seed Shop is a form of business from the village government that sells various kinds of plant seeds and fruits from nurseries by the local community. However, in its application the sales and transaction system still uses a fairly conventional method. By opening an offline store and marketing products through social media networks, the Sriwedari Seed Shop has less regular customers. Not to mention the risk of fraud from customers who order seeds through social media is a concern for sellers Therefore, this research was conducted with the intention of answering the problems above by creating an e-marketplace system in the form of an online store that will be integrated with a payment gateway that has various online payment methods. In addition, data security will also be applied to the payment system using the Advanced Encryption Standard (AES) cryptographic algorithm which functions to encrypt payment transaction data so that data records stored in the database are not easy to read and prevent misuse of data by parties who do not have access rights. The method used in developing this system is Rapid Application Development (RAD). This method is very suitable to be applied in software development with minimal resources so that it can speed up the iteration process at each stage of development while still paying attention to input from potential system users. The results of this research are an integrated e-marketplace system with payment gateway services that have various payment methods with transaction data security using the AES cryptographic algorithm.
Penerapan Metode EUCS Untuk Evaluasi Tingkat Kepuasan Pengguna Aplikasi PNM Digi Karyawan
Authors: Irumas Ima , Utamajaya Joy Nashar
Published: October 2023

The PNM Digi Employee application was designed by PT. PNM Mekaar Persero to make it easier for employees to perform attendance and some administrative services for daily needs such as bill payments, purchase of credit, investments and many more. The purpose of this study was to determine the level of employee satisfaction in using the PNM Digi Employee application. User satisfaction was measured so that it became input for the company in managing and developing the PNM Digi Employee application. For this reason, this study was conducted to measure the level of user satisfaction of the Digi Employee PNM application by applying the End User Computing Satisfaction method. To obtain data as research material, research questionnaires were distributed to employees by adopting the dimensions of the End User Computing Satisfaction method, namely the dimensions of Content, Accuracy, Format, Easy of Use and Timeliness. It was found that the employees of PT. PNM Mekaar is very satisfied in using the PNM Digi Employee application based on the results of the tests that have been carried out showing the percentage of all dimensions is worth above 80%, namely the Content dimension 85.3%, Accuracy dimension 83.7%, Format dimension 86.6%, Easy of dimension. Use 85.3% and Timeliness dimensions 86% with dimensions that have a significant effect, namely the dimensions of format and dimensions of Timeliness.
Analisis Kepuasan Pengguna Menggunakan Technology Acceptance Model Pada Aplikasi Dana
Authors: Musdalifah Musdalifah , Hadisaputro Elvin Leander
Published: October 2023

DANA is an application that provides convenience in digital transactions in Indonesia. Human lifestyle has begun to shift significantly, where everything is required to be done quickly, easily, and practically. One form of practicality that exists in the community is the rise of online systems. Currently, DANA is an e-wallet payment that is still relatively new in the community. Therefore, this DANA application is still in the development stage so this research needs to be done to attract millennials. This study aims to determine user satisfaction with the application of funds for employees of Telkom sharpening. This study uses the Technology Acceptance Model (TAM) method with five variables, namely Perceived Usefulness (X1), Perceived Ease Of Use (X2), Attitude Toward Using (X3), Behavior Intention To Use (X4) and Actual Use (Y). It is known that the research results Perceived Usefulness with a percentage value of 82.66%, perceived easy of use with a percentage of 80%, Attitude Toward Using with a percentage value of 80.53%, Behavioral Intention to Use with a percentage value of 80% and actual use with a percentage value of 82 ,4% with the category Strongly Agree. From the results of perceived satisfaction, it can be stated that Telkom Penajam Office Employees are very satisfied with using the Dana application.
Sistem Pakar Deteksi Covid-19 Dengan Lie Detection Menggunakan Metode Circle Hough Transform
Authors: Priambodo Bagus , Jumaryadi Yuwan
Published: October 2023

The number of health workers infected with Covid-19 in Indonesia continues to grow amid the coronavirus pandemic. Not only doctors, nurses and other medical support staff have been exposed to Covid-19. To date, IDI has recorded more than 180 health workers who have died from Corona. Health workers are dying because of a lack of Personal Protective Equipment (PPE) and fatigue. Prevention of direct contact between asymptomatic patients and health workers is a way to prevent health workers from contracting COVID-19. An expert system for diagnosing COVID-19 with lie detection is proposed to be used for patients who wish to seek treatment at a health center before they meet face-to-face with health workers. Several previous studies have proven that the certainty method can be used to diagnose COVID-19 with an accuracy of up to 90%, provided that the patient answers questions honestly. In this study, control questions and pupil detection were added using the circle hard transform to find out whether patients who wanted treatment did not lie when answering questions about symptoms of exposure to Covid, travel history and family history of exposure to Covid. The combination of an expert system and lie detection is expected to be the first protective alternative for health workers from asymptomatic patients. Based on the results of the application testing carried out, it can be seen that the movement of the patient's pupils when answering questions.
Analisis Pemilihan Supplier Kayu Pada Produk Furniture Menggunakan Metode Promethee
Authors: Utami Silvia Firda , Hermanto Koko , Adiasa Iksan , Indryani Tiya
Published: October 2023

UD. Rahman Mebel is a company that produces various forms of furniture such as chairs, tables, cabinets, doors, windows, and various other forms of furniture. the purpose of this research is to determine the best supplier at UD. Rahman Mebel uses the Promethee Method. Four alternative suppliers have been determined by UD. Rahman Furniture namely: UD. Rini, UD. Dedi Putra, UD. Rangga Putra, UD Ujud Alam Riski and there were also four criteria tested, namely quality, price, service, and delivery. Based on the results of observations through interviews stated that the difficulties experienced in selecting the best supplier according to the company's criteria. For this reason, a solution to this problem is needed, namely by analyzing the determination of supplier choices using the Promethee method. From the results of this study is, the highest net flow value is UD. Rangga Putra is in first place with a score of 0.9999. The second rank is UD. Ujud Alam Riski with a score of 0.3333. The third rank is UD. Dedi Putra with a score of -0.9999. And the last rank is UD. Rini with a value of -0.3333.