bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Effect of Acupuncture and Pressing of Traditional Chinese Medicine on Recovery of Delayed Muscle Soreness in Athletes
Authors: Yu Ming , Wang Xiaomei , Zhou Xiaoyu
Published: February 2022

In this study, we have analyzed numerous effects of the acupuncture and pressing of traditional Chinese medicine on recovery of delayed muscle soreness in athletes. To implement this idea, a total of 84 athletes with delayed muscle soreness treated in our hospital from January 2018 to June 2020 were included. According to the random number table method, they were divided into the experimental group and the control group: among them, 42 cases were in the experimental group and were treated by TCM acupuncture. In the control group, 42 athletes used rehabilitation training. Compared with serum CK levels in the control group, serum CK levels in the experimental group decreased after training, and there was a significant difference (

P
<
0.05

). After intensive training in the control group (

P
<
0.05

), it indicated that acupuncture and pressing of traditional Chinese medicine was effective in the recovery of fatigue after exercise, which was significantly better than that in the control group. The serum testosterone value of the experimental group before intensive training had no significant difference, but the serum testosterone value of the moxibustion group of male athletes after intensive training was significantly higher than that of the control group (

P
<
0.05

). Female athletes have a low blood testosterone base and are less affected by the gonad axis. There was no statistically significant difference in RPE scores before treatment. After treatment, the RPE score of the experimental group decreased rapidly (

P
<
0.05

), which was statistically significant compared with the control group (

P
<
0.05

). There was no significant difference in VAS scores before treatment. After treatment, the VAS score in the experimental group decreased rapidly (

P
<
0.05

) compared with the control group (

P
<
0.05

). After treatment, compared with the control group, the experimental group had a decrease in calf circumference, an increase in muscle strength, and an increase in the range of motion (

P
<
0.05

). Acupuncture and pressing of traditional Chinese medicine have obvious clinical application value in the treatment of delayed muscle soreness in athletes, and they have great clinical application value. Muscle injury is a common disease of athletes.
Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells
Authors: Che Hui , Ma Cheng , Li He , Yu Fenglei , Wei Yifan , Chen Hailong , Wu Jun , Ren Yongxin
Published: February 2022

Intervertebral disk degeneration (IDD) is a major cause of low back pain that becomes a prevalent age-related disease. However, the pathophysiological processes behind IDD are rarely known. Here, we used bioinformatics analysis based on the microarray datasets (GSE34095) to identify the differentially expressed genes (DEGs) as biomarkers and therapeutic targets in degenerated discs. From the previous studies, oxidative stress has been notified as a positive inducement of IDD, which causes DNA damage and accelerates cell senescence. Polyamine oxidase (PAOX), a member of the observed 1057 DEGs, is involved in polyamine metabolism and influences the oxidative balance in cells. However, it is uncertain if the IDD is implicated in the dysregulation of PAOX and polyamine metabolism. This study firstly verified the PAOX upregulation in human degenerated disc samples and applied an IL-1β-induced nucleus pulposus (NP) cell degeneration model to demonstrate that spermidine supplementation balanced polyamine metabolism and delayed NP cell senescence. Moreover, we confirmed that spermidine/N-acetylcysteine supplementation or Cdkn2a gene deletion stabilized the polyamine metabolism, suppressed oxidative stress, and therefore delayed the progress of IDD in older mice. Collectively, our study highlights the role of polyamine metabolism in IDD and foresees spermidine would be the advanced therapeutical drug for IDD.
Analysis of Factors Influencing Safety Attitudes of Operating Room Nurses and Their Cognition and Attitudes toward Adverse Event Reporting
Authors: Liao Xin , Zhang Peijia , Xu Xiaofeng , Zheng Dan , Wang Jing , Li Yunfei , Xie Li
Published: February 2022

Operating room nurses play a critical role in patient safety. The evaluation of safety attitudes of operating room nurses reflects their awareness and belief of patient safety. Currently, however, the research on the safety attitudes of operating room nurses is hard to track in the existing literature in China. Therefore, this paper was conducted to explore the factors influencing the safety attitudes of operating room nurses and their cognition and attitudes toward adverse event reporting. A total of 711 operating room nurses from 16 tertiary hospitals in Sichuan Province from March 1, 2018, to 2019 were selected. The general information of operating room nurses, such as age, gender, and years of service in the operating room, was obtained through the basic information questionnaire. The Chinese version of the Safety Attitudes Questionnaire (C-SAQ) was used to evaluate the safety attitude of operating room nurses, and the cognition and attitude of the subjects to adverse event reports were assessed through the questionnaire of cognition and attitude toward adverse event reporting. The average score of safety attitudes of operating room nurses was 4.20 ± 0.49. The two dimensions with a lower positive reaction rate of the safety attitudes of operating room nurses were stress recognition and working conditions. The main factors affecting the safety attitude of operating room nurses were night shifts, as well as cognition and attitudes toward adverse event reporting. There was a positive correlation between the total score of C-SAQ and the total score of cognition and attitudes toward adverse event reporting (

P
<
0.01

, r = 0.445). The safety attitude of operating room nurses is at the upper-middle level, but the stress recognition and working conditions need to be improved. Through the allocation of nursing human resources, the strengthening of hospital logistics support, and the establishment of nonpunitive nursing adverse event reporting system, the operating room safety can be significantly enhanced.
Clinical Study on the Efficacy of Microwave Ablation (MA) in the Treatment of Stage I Renal Clear Cell Carcinoma by CT and MRI Imaging
Authors: Zhu Jiang , Chen Si , Wang Yanchen , Gao TongBin , Ji Yongjian , Wang Shenyang
Published: February 2022

We have proposed an effective mechanism to corroborate the efficacy of microwave ablation (MA) in the treatment of stage I renal clear cell carcinoma in this paper. For this purpose, a total of 96 patients with stage I renal clear cell carcinoma presented in our hospital from May 2018 to January 2021 were randomly divided into CT group (n = 48) and MRI group (n = 48). Patients in both groups were treated with microwave ablation after pathological diagnosis. Patients in the CT group received enhanced CT examination to monitor the therapeutic effect; in contrast, patients in the MRI group received MRI examination to monitor their therapeutic effect. The focus areas before and after tumor microwave ablation were compared between the two groups. The patients were followed up to 1 year after the operation, and the microwave ablation inactivation rates of the two groups were compared according to the postoperative follow-up results. There was no significant difference between CT and MRI in the levels of long and short diameter before and after microwave ablation of renal clear cell carcinoma (P > 0.05). In the CT group, CT examination was performed within 24 hours after microwave ablation treatment, and 44 of 48 ablation lesions showed complete ablation. The remaining 4 lesions showed nodular heterogeneous enhancement in the arterial phase, indicating that the tumor remained. Microwave ablation was performed on the residual lesions during the operation, and then enhanced CT was performed again to show that the lesions were ablated completely. In the MRI group, MRI examination was performed within 24 hours after microwave ablation treatment, and 45 of 48 ablation lesions showed complete ablation. The remaining 3 lesions showed nodular heterogeneous enhancement in the arterial phase, indicating that the tumor remained. Microwave ablation was performed on the residual lesions during the operation, and MRI examination showed that the lesions were ablated completely. The patients were followed up to 1 year after the operation, and the microwave ablation inactivation rate of the two groups was compared according to the postoperative follow-up results as the gold standard. The inactivation rate of microwave ablation in the CT group was 89.58 (43/48). The inactivation rate of microwave ablation in the MRI group was 100.00% (48/48). The inactivation rate of microwave ablation in the MRI group was higher than that in the CT group (χ2 = 5.275, P = 0.021).
Fault Location Method in Nonsolid-Earthed Network Based on Spatial Domain Image Fusion and Convolution Neural Network
Authors: Hou Sizu , Guo Wei
Published: February 2022

Given that the single-terminal traveling wave location method has significant errors, a novel fault location method based on the spatial domain image fusion and convolutional neural network (CNN) is proposed. Firstly, the three-phase traveling wave can be decoupled by the phase-mode transformation matrix for obtaining the line-mode component of the traveling wave. Secondly, the 1D line-mode traveling wave can be converted into a 2D image by the Gramian angular field (GAF). The 1D line-mode component can be mapped into the color, point, line, and other characteristic parameters of the 2D image. In order to expand the invisible information of the line-mode traveling wave, the images obtained by the Gramian angular summation field (GASF) and Gramian angular difference field (GADF) are weighted and fused. Finally, the CNN can be used to autonomously mine the characteristic parameters of the weight-fusion image and realize fault location. The simulation results show that the proposed method does not need to be considered in the traveling wave head and the traveling wave speed. The localization method is not affected by fault time, fault distance, or transition resistance factors. It possesses high reliability with an absolute range error of no more than 200 m.
Parallel Cross-Sparse Filtering Networks and Its Application on Fault Diagnosis of Rotating Machinery
Authors: Wang Shan , Han Baokun , Bao Huaiqian , Wang Jinrui , Zhang Zongzhen
Published: February 2022

Intelligent diagnosis method has become a new focus for researchers, which can get rid of the dependence of diagnostic experience and prior knowledge. However, in practical application, to deal with the new fault type of mechanical equipment, the number of fault labels of the diagnosis model needs to be increased. We must retrain the whole training model, which is a time-consuming process. To solve this problem, higher requirements are put forward for the generalization ability and universality of the algorithm. In view of the feature extraction advantages of cross-sparse filtering (Cr-SF), which can be regarded as an unsupervised minimum entropy learning method using the maximization of the proxy of sparsity, this paper proposed a parallel network based on Cr-SF. The feature extraction process of each sample is independent, and the feature extraction and classifier training process are separated. Therefore, the most prominent advantage of the proposed method is that when a new fault occurs, it only needs to extract the feature of the new fault separately and then input it to the classifier at the last layer for training. The experimental results show that the proposed method can obtain high accuracy and stability and can significantly improve the adaptability of intelligent fault diagnosis in practical application.
Experimental Investigation of the Impact of Necking Position on Pile Capacity Assisted with Transparent Soil Technology
Authors: Yang Qingnian , Shao Jianli , Xu Zhijun , Miao Yu
Published: February 2022

Necking in different positions of a pile body has a significant influence on the bearing performance of a single pile. The transparent soil model experiment was adopted to investigate the impacts of necking positions on the vertical bearing capacity of a single pile and the soil deformation around the pile, and subsequently, the causes of the variation of bearing capacity were analyzed. The results show that the existence of necking does not change the bearing behavior of single pile as pile friction resistance. The bearing capacity of piles decreased by 8.21% and increased by 7.30% when the necking is located in the shallow and middle pile body, respectively, while it did not change significantly when the defects were in the deep part of the pile. The necking position has a significant effect on the deformation and deformation range of soil. The soils at the top, side, and near the end of a pile were mainly influenced by shallow necking, middle necking, and deep necking, respectively. The soils at the location of necking had apparent settlement phenomenon as the piles subsided. The soils at shallow necking’s locations were relatively loose, which reduced the side friction force of piles and finally resulted in a reduction of bearing capacity of a single pile. With the increase of the load, the soil around piles gradually developed penetration phenomenon (large deformation), while the soil at the end of pile moved up against pile settlement, which made the necking soil in the middle denser. The loss of side friction resistance was less than the resistance from the necking, which gave birth to an increase in the bearing capacity of a single pile. It was finally found that the side friction resistance and the resistance caused by necking were the main factors governing the bearing capacity of necking single piles.
A New Case of Rare Microdeletion 10q22.3q23 along with Mosaic Klinefelter Syndrome Associated with Facial Dysmorphic Finding, Atrial Ventricular Septal Defect, and Motor Retardation
Authors: Dincsoy Bir Firdevs , Silan Fatma , Velickovic Jelena , Berkay Akcan Mehmet , Ozdemir Ozturk
Published: February 2022

The chromosome 10q22.3q23.2 deletion syndrome is characterized by craniofacial dysmorphic features, developmental delay, congenital heart defect, and hand/foot abnormalities. In this study, we report a patient carrying a microdeletion of 7.5 Mb at 10q22.3q23.2 and in addition a mosaicism mos 47,XXY[47]/46,XY[23].This male patient was 3 years and 3 months years old at the time of genetic evaluation. Atrial ventricular septal defect (AVSD), mild hypotonia, torticollis, and left-sided club foot were noticed after birth. The boy had surgical correction of the AVSD and the club foot. His dysmorphic features were frontal bossing, overfolded ear helix, hypertelorism, epicanthal folds, broad base of nose, flat nasal bridge, full cheeks, thick lips, micrognathia, and joint hyperextensibility. His speech/language development was delayed. Klinefelter syndrome is one of the most common congenital chromosomal abnormalities, but usually it is detected in puberty or in adulthood when reproductive failure occurs. Deletions in the 10q22.3q23.2 region are rare, and previously only a few numbers of cases were described with this microdeletion, but none of them together with Klinefelter syndrome and it could be associated with our case clinical features. The new case described will improve understanding the phenotype associated with 10q22.3q23.2 microdeletions. By presenting this case, we aimed to improve the understanding of the phenotype caused by the rare 10q22.3q23.2 deletion and to show the rare coexistence of this deletion with Klinefelter syndrome.
Simultaneous and Sequential Development of Sixth Nerve Palsy and Horner’s Syndrome from Carotid Cavernous Sinus Fistulas
Authors: Yuan Po Hsiang (Shawn) , Micieli Jonathan A.
Published: February 2022

The combination of ipsilateral sixth nerve palsy (6NP) and Horner’s syndrome (Horner’s) is a localizing sign of an injury to the posterior cavernous sinus. The presentation and clinical course of 3 patients presenting with coexisting ipsilateral 6NP and Horner’s as a result of carotid cavernous sinus fistulas (CCFs) are discussed in this case series. We highlight these cases to show the possible sequence of events: (i) simultaneous discovery of 6NP and Horner’s, (ii) 6NP followed by Horner’s, and (iii) Horner’s followed by 6NP. It is important to carefully assess for Horner’s in patients with 6NP as this has high localizing value. In patients with a red eye consistent with a CCF, identifying Horner’s also has high localizing value and can confirm the suspicion of a CCF. Clinicians should recognize that although 6NP and Horner’s localize to the cavernous sinus and may be due to a CCF, they may appear in isolation or sequentially. It is also important to understand that Horner’s and 6NP have different prognoses: 6NP usually resolves over time, whereas Horner’s tends to persist.
Health-Related Quality-of-Life Outcomes after Transoral Robotic Surgery for T1 and T2 Supraglottic Laryngeal Carcinoma Compared to the Transcervical Open Supraglottic Approach
Authors: Kaya Kamil Hakan , Karaman Koç Arzu , Kayhan Fatma Tülin
Published: February 2022

Introduction: This prospective controlled study evaluated and compared health-related quality of life (HRQOL), after transoral robotic supraglottic laryngectomy (TORSGL) versus transcervical open supraglottic laryngectomy (TCOSGL) in patients with T1 and T2 supraglottic laryngeal carcinoma (SLC). Methods: The TORSGL group comprised 14 patients, and the TCOSGL group comprised 13 patients. All 27 patients completed the European Organization for Research and Treatment of Cancer 30-item core quality-of-life questionnaire version 3.0 (EORTC QLQ-C30), the European Organization for Research and Treatment of Cancer head-and-neck cancer-specific module (EORTC QLQ-H&N35), before treatment and during the early and the late postoperative periods. Results: The present prospective study demonstrated the near-term postoperative HRQOL of patients with T1 or T2 SLC treated with TORSGL (Group A) or TCOSGL (Group B). On comparison of EORTC QLQ-C30 data for the two groups in the early postoperative period, all functional subscale scores and global health status scores were statistically significantly lower (all p < 0.05) in Group A than in Group B and in the late postoperative period, other than the cognitive function score (p = 0.450), all functional subscale scores and global health status scores were statistically significantly lower (all p < 0.05) in Group A than in Group B. On comparison of the EORTC QLQ-H&N35 data for the two groups in the early postoperative period, except for the teeth problems scale score (p = 0.061), all symptom scale scores were statistically significantly lower in Group A than in Group B (all p < 0.05) and in the late postoperative period, the speech, social eating, social contact, and coughing scale scores were statistically significantly lower (p = 0,0215, p = 0.021, p = 0.01, p = 0.011, respectively) in Group A than in Group B. HRQOL parameters recovered in the late postoperative period in both groups; recovery was better in Group A. Discussion/Conclusion: This study suggested that TORSGL may provide patients with a better HRQOL than those TCOSGL, especially in the early period, but also in the late period.
Cervical Myelopathy Associated with Deep Neck Muscle Rhabdomyolysis after Polysubstance Abuse: A Case Report
Authors: Honkaniemi Jari , Rummukainen Jaana , Väänänen Pinne , Vuorialho Matti
Published: February 2022

When used appropriately, buprenorphine and oxycodone are safe drugs. They are, however, widely abused in combination with other drugs. Here we describe a case series of 8 patients with cervical myelopathy and rhabdomyolysis of the adjacent deep neck muscles after using an opioid in combination with other drugs. All patients were young males who had a previous history of polysubstance abuse. Six of the patients had used buprenorphine in combination with pregabalin and/or benzodiazepines, and one patient had used oxycodone with pregabalin and/or benzodiazepines. One patient used buprenorphine with amphetamine. After taking the drugs, they all reported feeling drowsy and then falling asleep. On waking, they noticed weakness in their extremities. However, only one patient woke with his head in a flexed position. A varying degree of tetraparesis was observed. Cerebrospinal fluid analysis revealed elevated protein levels and white blood cell count. Blood creatine kinase was elevated in 7 patients. Spinal cord MRI showed a hyperintense spinal lesion at the level of C1 – Th3 vertebrae associated with rhabdomyolysis in the adjacent, paravertebral deep neck muscles. We suggest that polysubstance abuse, especially the combination of an opioid with another drug with GABA-agonistic properties, caused a compartment syndrome of the deep paravertebral muscles without excessive head flexion. This subsequently led to compression of the external vascular structures, resulting in venous congestive myelopathy.
Lower Incidence of Postoperative Urinary Retention in Robotic Total Mesorectal Excision for Low Rectal Cancer Compared with Laparoscopic Surgery
Authors: Lee Tae Hoon , Kwak Jung-Myun , Yu Da Young , Yang Kyung-Sook , Baek Se Jin , Kim Jin , Kim Seon Hahn
Published: February 2022

Introduction: The incidence and clinical significance of postoperative urinary retention (POUR) remain high. This study aimed to evaluate the incidence of POUR and related risk factors in patients who underwent total mesorectal excision (TMR) for low rectal cancer. Methods: This study is a retrospective review of a prospectively collected colorectal database from a single center. Data from patients who underwent surgery for low rectal cancer between September 2006 and May 2017 were analyzed to assess the risk factors of POUR. POUR was considered inability to void after urinary catheter removal requiring catheter reinsertion and difficulty in bladder emptying requiring intermittent catheterization. Results: Of 555 patients with low rectal cancer, 78 (14.1%) developed POUR. Based on multivariate logistic regression analysis, laparoscopic TMR (odds ratio [OR]; 2.114, 95% confidence interval [CI]; 1.212–3.689, p = 0.008) and postoperative ileus (OR; 2.389, 95% CI; 1.282–4.450, p = 0.006) were independent risk factors of POUR. Male gender, advanced age, neoadjuvant chemoradiation, longer operative time, abdominoperineal resection, and lateral pelvic lymph node dissection were not associated with POUR. Advanced age over 65 years also failed to show statistical significance (OR; 1.604, 95% CI; 0.965–2.668, p = 0.068). Conclusion: Laparoscopic approach and postoperative ileus are risk factors for POUR after low rectal cancer surgery. We postulate that the benefits of robotic surgical systems compared to a laparoscopic approach may reduce the incidence of POUR.
Transjugular Intrahepatic Portosystemic Shunt for Portal Vein Cavernous Transformation: A Systematic Review and Single-Arm Meta-Analysis
Authors: Yan Jingxin , Deng Manjun , Wang Yaxuan , Zhu Meilin , Li Ting , Hu Haiyang , Lei Zhenwu , Guo Yingxing , Zhang Lushun
Published: February 2022

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is technically challenging in the treatment of portal vein cavernous transformation (PVCT), and there is no high-quality evidence regarding whether it is an option for patients with PVCT. We carried out a systematic review and meta-analysis to assess the feasibility and safety of TIPS for PVCT. Methods: Systematic search of PubMed, Chinese National Knowledge Infrastructure (CNKI) database, Cochrane Library, Embase, and Wanfang database through December 2021 for appropriate studies reporting efficacy and safety in patients with PVCT undergoing TIPS. The main outcome included the technical success rate, postoperative rebleeding rate, postoperative hepatic encephalopathy rate, stent patency rate, preoperative, and postoperative portal pressure. Results: Ten studies, including 292 patients were included. Our results showed that TIPS was technically successful in 82.97% (95% confidence interval [CI]: 77.14%–88.41%, p = 0.297) with low heterogeneity (I2 = 18.39%, p = 0.279). Postoperative rebleeding occurred in 9.56% (95% CI: 4.55%–16.77%, p = 0.073) with moderate heterogeneity (I2 = 46.45%, p = 0.06). Postoperative hepatic encephalopathy occurred in 18.55% (95% CI: 9.23%–27.05%, p = 0.343) with moderate heterogeneity (I2 = 48.62%, p = 0.049). Stent patency during follow-up was in 78.43% (95% CI: 70.74%–85.20%, p = 0.805) with low heterogeneity (I2 = 0%, p = 0.654). Postoperative portal pressure significantly reduced (WMD = 12.79 mm Hg, 95% CI: 12.09–13.48 mm Hg, p < 0.00001) with high heterogeneity (I2 = 61.4%, p = 0.02). Both Begg test and funnel plot showed that there was no significant publication bias. Conclusions: TIPS is feasible and safe in patients with PVCT and PVCT should not be considered an absolute contraindication to TIPS.
Pancreatic Ductal Adenocarcinoma: New Insights into the Actions of Vitamin A
Authors: Mere Del Aguila Eduardo , Tang Xiao-Han , Gudas Lorraine J.
Published: February 2022

Background: Pancreatic ductal adenocarcinoma (PDAC) is a gland-forming malignancy arising in the pancreas. It is estimated that in developed countries the incidence of PDAC will continue to rise, and PDAC is now the fourth leading cause of cancer-related deaths in the USA. The mortality of PDAC patients closely parallels the incidence rate, as this malignancy generally remains asymptomatic until it reaches an advanced stage. Summary: The poor prognosis results from the aggressive nature of the tumor, late detection, and resistance to chemotherapy and radiotherapy. Retinoids, vitamin A (retinol) and its metabolites, such as retinoic acid (RA), play critical roles in important biological functions, including cell growth and differentiation, development, metabolism, and immunity. The actions of retinoids in maintaining normal pancreatic functions have generated considerable research interest from investigators interested in understanding and treating PDAC. Altered expression of retinoid receptors and other RA signaling pathway genes in human cancers offers opportunities for target discovery, drug design, and personalized medicine for distinct molecular retinoid subtypes. Key Messages: The goals of this review are to explore the potential activities of retinoids in the pancreas, to assess the evidence that retinoid functions become dysregulated in PDAC, and to describe the actions of retinoids in new therapies developed to increase patient survival.
How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior: an Observational Follow-up Study
Authors: Widén Elisabeth , Junna Nella , Ruotsalainen Sanni , Surakka Ida , Mars Nina , Ripatti Pietari , Partanen Juulia J. , Aro Johanna , Mustonen Pekka , Tuomi Tiinamaija , Palotie Aarno , Salomaa Veikko , Kaprio Jaakko , Partanen Jukka , Hotakainen Kristina , Pöllänen Pasi , Ripatti Samuli
Published: February 2022

Background:

Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear.

Methods:

We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for atherosclerotic cardiovascular disease both by a traditional risk score and a composite score combining the effect of a polygenic risk score and clinical risk factors. We then tested how returning the personal risk information with an interactive web-tool impacted on the participants’ health behavior.

Results:

When reassessed after 1.5 years by a clinical visit and questionnaires, 20.8% of individuals at high (>10%) 10-year atherosclerotic cardiovascular disease risk had seen a doctor, 12.4% reported weight loss, 14.2% of smokers had quit smoking, and 15.4% had signed up for health coaching online. Altogether, 42.6% of persons at high risk had made one or more health behavioral changes versus 33.5% of persons at low/average risk such that higher baseline risk predicted a favorable change (OR [CI], 1.53 [1.37–1.72] for persons at high risk versus the rest,
P
<0.001), with both high clinical (
P
<0.001) and genomic risk (OR [CI], 1.10 [1.03–1.17],
P
=0.003) contributing independently.

Conclusions:

Web-based communication of personal atherosclerotic cardiovascular disease risk-data including polygenic risk to middle-aged persons motivates positive changes in health behavior and the propensity to seek care. It supports integration of genomic information into clinical risk calculators as a feasible approach to enhance disease prevention.
Moving Towards Equity With Digital Health Innovations for Stroke Care
Authors: Verma Aradhana , Towfighi Amytis , Brown Arleen , Abhat Anshu , Casillas Alejandra
Published: February 2022

Digital health has long been championed as a means to expanding access to health care. Now that the COVID-19 pandemic accelerated many health systems’ integration of digital tools for care, digital health may provide a path towards more accessible stroke prevention and treatment, particularly for historically disadvantaged patient populations. Stroke management is composed of multiple time points where digital health innovations have the potential to augment health access and treatment: from primary prevention, to the time-sensitive detection of ischemic stroke, administration of thrombolytic agents and consideration for endovascular interventions, to appropriate post-acute care, rehabilitation, and lifelong secondary stroke prevention—stroke care relies on a multidisciplinary and standardized approach. However, as we discuss pointedly in this Focused Update, underrepresented individuals face multilevel digital health disparities that potentially diminish the benefits of these digital advances. As such, these multilevel needs must be discussed and accounted for as health systems seek to integrate innovative and equitable digital health solutions towards stroke care.
Controversy and Growth Points in the Activity Theory in Psychology
Authors: Maidansky Andrey D.
Published: February 2022

Background. Activity theory is the most powerful and influential current of Russian psychology in the world today. It considers the psyche to be a special form or function of object-oriented activity. The level of psychical development of a living being is directly proportional to the variety and freedom of its activities. Objective. The aim of this article is to explore the key growth points in activity psychology through the analysis of arguments among its creators — S.L. Rubinstein, L.S. Vygotsky, A.N. Leontiev, and P.Ja. Galperin. Vygotsky dreamed of building a scientific psychology on the model of Marx’s Das Kapital; his project is resumed in this article. Results. The author traces how, due to Walter Cannon’s experimental research, Vygotsky came to the activity concept of affect, in which he finds the primary “cell” of the psyche. The problem of the relationship between concept and affect became the central problem of his “acmeistic psychology.” While Vygotsky focused on the affective reflection of activity in the subject, Leontiev focused on its cognitive side, directed toward the object. In the objective world, the psyche serves a person’s material life-activity, performing a search-and-orientation function. Leontiev considered consciousness a structural projection of that activity, but Galperin argued that Leontiev never managed to overcome the dualism of consciousness and activity. Conclusion. A new path to the realization of Vygotsky’s dream is outlined. The proposed solution is based on Spinoza’s concept of affect and the idea of freedom, interpreted as “the affect in the concept.” (Vygotsky)
The first molecular phylogeny of Blosyrini weevils (Coleoptera: Curculionidae: Entiminae) rejects monophyly of the tribe and documents a new Asian clade with the highest diversity in the Hengduan Mountains
Authors: GREBENNIKOV VASILY V.
Published: February 2022

This paper targets diversity and phylogeny of the Old World weevil tribe Blosyrini and, specifically, its Asian members. Phylogenetic analysis of one mitochondrial and two nuclear DNA fragments from 78 terminals reveals that Blosyrini weevils, although monophyletic in Asia, in Madagascar, and in continental Africa, do not share a unique common ancestor. Instead, they form a strongly supported clade together with representatives of two other tribes of broad-nosed weevils: Cneorhinini and Dermatodini. The Asian members of the tribe form a moderately supported clade, of which the monophyletic genus Trachyphloeoides is a sister to the strongly supported rest, Blosyrini Clade X (BCX). Owing to the convoluted and non-phylogenetic taxonomy, BCX cannot be at present reliably referred to by any existing genus-group name. All 112 DNA barcodes of BCX (including one larva) from China, Kazakhstan, Kyrgyzstan, and Nepal form 34 Barcode Index Numbers (BINs). Each of seven comprehensively sampled mountainous localities in Sichuan (Gongga Shan, Emei Shan, Songpan) and Yunnan (Cang Shan, Gaoligong Shan, Haba Shan, Jizu Shan) supports between one and six BINs of BCX. With two exceptions, all BINs of BCX in Sichuan (8) and Yunnan (10) display strong biological preferences for either mid-altitude primary deciduous forests or the high elevation alpine zone. Seven strongly supported clades are recognized within BCX, some of them morphologically diagnosable. Temporal analysis corroborates the results of BIN clustering and interrelationships within BCX. The most recent common ancestor of BCX lived in the mid-Miocene (14.15 Ma, 95% confidence interval 17.5–11.2 Ma), with much of the subsequent diversification preceding or coinciding with the Pliocene-Pleistocene climatic fluctuations.
Arctic Maritime Cyclone Distribution and Trends in the ERA5 Reanalysis
Authors: Chen Zihan , Lynch Amanda H.
Published: February 2022

We present a tracking algorithm for synoptic to meso-α-scale Arctic cyclones that differentiates between cold- and warm-core systems. The algorithm is applied to the ERA5 reanalysis north of 60°N from 1950 to 2019. In this dataset, over one-half of the cyclones that meet minimum intensity and duration thresholds can be classified as cold-core systems. Systems that undergo transition, typically from cold to warm core, make up 27.2% of cyclones and are longer lived. The relatively infrequent warm-core cyclones are more intense and are most common in winter. The Arctic-wide occurrence of maritime cyclones has increased from 1979 to 2019 when compared with the period from 1950 to 1978, but the trends have high interannual variability. This shift has ramifications for transportation, fisheries, and extractive industries, as well as impacts on communities across the Arctic.
Reconciling Conflicting Accounts of Local Radiative Feedbacks in Climate Models
Authors: Hedemann Christopher , Mauritsen Thorsten , Jungclaus Johann , Marotzke Jochem
Published: February 2022

The literature offers conflicting findings about which regions contribute most to increases in the global radiative feedback after a forcing increase. This paper explains the disagreement by discriminating between two common definitions of the local feedback, which use either local temperature or global temperature as their basis. Although the two definitions of feedback have been previously compared in aquaplanet models with slab oceans, here the definitions are compared for the first time in an atmosphere–ocean general circulation model (MPI-ESM1.2) integrated over four doublings of atmospheric CO2 concentrations. Large differences between the definitions can be seen in all feedbacks, but especially in the temperature and water vapor feedbacks. Differences of up to 10 W m−2 K−1 over the Southern Ocean can be explained by the pattern of surface warming, which weights the local feedbacks and reduces their contribution to the global mean. This finding is, however, dependent on the resolution of analysis, because the local-temperature definition is mathematically inconsistent across spatial scales. Furthermore, attempts to estimate the effect of “pattern weighting” by separating local feedbacks and warming patterns at the gridcell level fail, because the radiative change in key tropical regions is also determined by tropospheric stability via the global circulation. These findings indicate that studies of regional feedback change are more sensitive to methodological choices than previously thought, and that the tropics most likely dominate regional contributions to global radiative feedback change on decadal to centennial time scales.

Significance Statement

Radiative feedbacks are processes that either intensify or damp global surface warming. We compare two ways to define local radiative feedbacks in a climate model and find that the choice of definition drastically impacts the results. Differences in feedback between the definitions are up to 10 W m−2 K−1 over the Southern Ocean; by comparison, the estimate of the true global feedback is around −1 W m−2 K−1. Also, one of the definitions is mathematically inconsistent across different scales of spatial aggregation. Our findings matter because they help to reconcile disagreement in previous studies about which regions dominate global radiative feedback change in model simulations of global warming.
Modeling the Convective Boundary Layer in the Terra Incognita: Evaluation of Different Strategies with Real-Case Simulations
Authors: Giani Paolo , Genton Marc G. , Crippa Paola
Published: February 2022

Modeling atmospheric turbulence in the convective boundary layer is challenging at kilometer and subkilometer resolutions, as the horizontal grid spacing approaches the size of the most energetic turbulent eddies. In this range of resolutions, termed terra incognita or gray zone, partially resolved convective structures are grid dependent and neither traditional 1D mesoscale parameterizations nor 3D large-eddy simulations closures are theoretically appropriate. Leveraging on a new set of one-way nested, full-physics multiscale numerical experiments, we quantify the magnitude of the errors introduced at gray zone resolutions in a real-case application and we provide new perspectives on recently proposed modeling approaches. The new set of experiments is forced by real-time-varying boundary conditions, spans a wide range of scales, and includes traditional 1D schemes, 3D closures, scale-aware parameterizations, and strategies to suppress resolved convection at gray zone resolutions. The study area is Riyadh (Saudi Arabia), where deep CBLs develop owing to strong convective conditions. Detailed analyses of our experiments, including validation with radiosonde data, calculations of spectral features, and partitioning of turbulent fluxes between resolved and subgrid scales, show that (i) grid-dependent convective structures entail minor impacts on the first-order characteristics of the fully developed boundary layer due to some degree of implicit scale awareness of 1D parameterizations and (ii) 3D closures and scale-aware schemes outperform traditional 1D schemes especially in the surface layer, among other findings. The new suite of experiments provides a benchmark of real simulations that can be extended to assess how new turbulence closures perform at gray zone resolutions.

Significance Statement

As recent advances in high-performance computing are leading to a new era in numerical simulations, regional atmospheric models can now increase their resolution to the widely unexplored kilometer and subkilometer range. While increasing the resolution of atmospheric models is desirable to (i) have more realistic weather and air quality predictions and (ii) better represent boundary conditions for microscale models, kilometer and subkilometer grid spacings pose some theoretical challenges that need to be addressed by the atmospheric modeling community. In this work we run a set of numerical experiments for a real case study that aim to offer new perspectives on recently developed modeling strategies and identify the most promising directions that should be investigated by follow-up studies.
The Meteorology of the Tathra Bushfire
Authors: Wilke David J. , Kepert Jeffrey D. , Tory Kevin J.
Published: February 2022

The meteorological conditions over the South Coast of New South Wales, Australia, are investigated on 18 March 2018, the day of the Tathra bushfire. We present an analysis of the event based on high-resolution (100- and 400-m grid-length) simulations with the Bureau of Meteorology’s ACCESS numerical weather prediction system and available observations. Through this analysis we find several mesoscale features that likely contributed to the extreme fire event. Key among these was the development of horizontal convective rolls, which emanated from inland and aided the fire’s spread toward Tathra. The rolls interacted with the terrain to produce complex regions of strongly ascending and descending air, likely accelerating the lofting of firebrands and potentially contributing to the significant lee-slope fire behavior observed. Mountain waves, specifically trapped lee waves, occurred on the day and are hypothesized to have contributed to the strong winds around the time the fire began. These waves may also have influenced conditions during the period of peak fire activity when the fire spotted across the Bega River and impacted Tathra. Finally, the passage of the cold front through the fireground was complex, with frontal regression observed at a nearby station and likely also through Tathra. We postulate that interactions between the strong prefrontal flow and the initially weak change resulted in highly variable and dangerous fire weather across the fireground for a significant period after the change initially occurred.

Significance Statement

The town of Tathra on the South Coast of New South Wales, Australia, was devastated on 18 March 2018, when a wildfire ignited in nearby bushland and quickly intensified to impact the town. Using high-resolution numerical weather simulations, we investigate the conditions that led to the extreme fire behavior. The simulations show that the fire ignited and intensified under highly variable conditions driven by complex interactions between the flow over nearby mountains and the passage of a strong cold front. This case study highlights the value of such models in understanding high-impact weather for the purpose of hazard preparedness and emergency response. Additionally, it contributes to a growing number of case studies that indicate the future direction of high-impact forecast services.
Relationship Between Blood Lipid Levels and Mortality in Hospitalized COVID-19 Patients
Authors: Aydın Sidar Ş , Aksakal Emrah , Aydınyılmaz Faruk , Gülcü Oktay , Saraç İbrahim , Kalkan Kamuran , Aydemir Selim , Doğan Remziye , Aksu Uğur , Tanboğa İbrahim H
Published: February 2022

People with comorbid conditions are at increased risk of developing severe/fatal coronavirus disease 2019 (COVID-19). We aimed to investigate the relationship between lipid levels and mortality in patients hospitalized for COVID-19 infection. In this retrospective study, we collected the details of 5274 COVID-19 patients who were diagnosed using the polymerase chain reaction and/or computed tomography and were hospitalized between March and November 2020. Patients (n = 4118) whose blood lipid levels were checked within the first 24 h after hospitalization were included in the study. Multivariable cox proportional hazards regression was used to assess the relationship between lipid variables such as low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) and death. There was a statistically significant association between LDL-C, HDL-C, and TG levels and the risk of death ( P =.002, <.001, and .035, respectively). Low and high LDL-C, low HDL-C, and high TG levels were negatively associated with COVID-19-related mortality. Blood lipid levels may be useful predictors of mortality in COVID-19 patients.
In Situ Raman Spectroscopy Monitoring of Material Changes During Proton Irradiation
Authors: Canizarès Aurelien , Foucher Frederic , Baqué Mickael , de Vera Jean-Pierre , Sauvage Thierry , Wendling Olivier , Bellamy Aurelien , Sigot Paul , Georgelin Thomas , Simon Patrick , Westall Frances
Published: February 2022

Organic molecules are prime targets in the search for life on other planetary bodies in the Solar System. Understanding their preservation potential and detectability after ionic irradiation, with fluences potentially representing those received for several millions to billions of years at Mars or in interplanetary space, is a crucial goal for astrobiology research. In order to be able to perform in situ characterization of such organic molecules under ionic irradiation in the near future, a feasibility experiment was performed with polymer test samples to validate the optical configuration and the irradiation chamber geometry. We present here a Raman in situ investigation of the evolution of a series of polymers during proton irradiation. To achieve this goal, a new type of Raman optical probe was designed, which documented that proton irradiation (with a final fluence of 3.1014 at·cm–2) leads to an increase in the background level of the signal, potentially explained by the scission of the polymeric chains and by atom displacements creating defects in the materials. To improve the setup further, a micro-Raman probe and a temperature-controlled sample holder are under development to provide higher spectral and spatial resolutions (by reducing the depth of field and laser spot size), to permit Raman mapping as well as to avoid any thermal effects.
Explaining intentional cultural destruction in the Syrian Civil War
Authors: Mantilla Luis Felipe , Knezevic Zorana
Published: February 2022

Why, when, and where do participants in civil wars engage in intentional cultural destruction (ICD)? Focusing on the case of ISIS in Syria, our article examines how ideological and strategic considerations intersect to shape ICD campaigns. We propose that ideologically motivated combatants rely on ICD as a form of collective violence aimed at reinforcing territorial control, and hypothesize that ICD events are most likely in areas where a group is actively contesting territory. Using an original dataset that combines data on ICD events in Syria with measures of combatant control, we conduct a quantitative analysis of the main factors contributing to the incidence of ISIS-inflicted ICD across Syria’s governorates and over time. We rely on panel regressions to assess the importance of territorial control relative to other prominent factors contributing to ICD, such as the presence of internationally recognized cultural sites and the share of ethno-religious minorities. We find that the dynamics of combatant control play a central role in accounting for the distribution of ISIS-inflicted ICD events in Syria.