bluuebunny/crossref_metadata_2025 huggingface dataset:
Der Leib – ein merkwürdiges ‚Ding‘. Zum Leib als Werkzeug und Vorstellung
Authors: Streubel Thorsten
Published: September 2022

Abstract. Since Arthur Schopenhauer’s conceptual differentiation between the two modes of givenness regarding the own body, theoretical philosophy is confronted with another serious problem, which is distinct from the problem about the relation of mind and brain. In German language there are two terms to mark the two relata: Körper (living body) and Leib (~ the felt body). But both the ontological mode of Leib and body and their relation are still obscure. In this paper I propose a solution of the Body-Leib-Problem by analyzing the relation between Leib and body, Leib and consciousness, and Leib and world. My essential thesis is that the living body is the representation of the Leib in the world. And this implies that Leib and body are neither identical nor completely different entities. And most notably: the Leib isn’t the mental representation of the own body.
Berkeleys Idealismus
Authors: Dierig Simon
Published: September 2022

Abstract. According to a widespread interpretation of Berkeley’s philosophy, advocated, for example, by Kant and Reid, Berkeley’s main claim in the Treatise Concerning the Principles of Human Knowledge is that there are no material, but only mental entities. In the following essay, it is argued that this reading of Berkeley’s idealism is mistaken. Berkeley does not hold ontological idealism, that is, the view that there is not a material world, to be true, but only counterfactual idealism, that is, the claim that material entities counterfactually depend upon mental substances for their existence. While defending this interpretation of Berkeley’s philosophy, I examine in some detail his theory of ideas and his account of corporeal substances. I conclude by discussing several objections to the reading of Berkeley’s idealism advanced in this essay.
Potentialität und Disposition in der Diskussion über den Status des menschlichen Embryos: Zur Ontologie des Potentialitätsarguments
Authors: Meincke Anne Sophie
Published: September 2022

Abstract. The argument from potentiality for embryo protection relies on the assumption of a specific developmental potential of human embryos: As human embryos under normal conditions naturally develop into beings whose strong moral status is uncontroversial, namely into human persons, they likewise enjoy strong moral status. In my paper, I endeavour to spell out the ontological foundations of the argument from potentiality and to discuss them critically in the light of new empirical findings in embryology. Particular attention is hereby paid to recent attempts to analyse the relevant notion of potentiality in terms of dispositions possessed by human embryos. I argue that, putting aside inappropriate essentialist speculations, there is no straightforward disposition of an embryo to become a person; such a disposition, if any, being rather successively generated in a multi-factored, highly context-sensitive process of biological development.
It’s Not (Only) The Joke’s Fault: A Speech Act Approach To Offensive Humor
Authors: Koch Daniel
Published: September 2022

Abstract. Usually the ethics of humor revolves around the content of humor. After giving a synopsis and exposing some shortcomings of the recent controversies, this paper takes into account additional aspects and proposes a change of perspective from token to type level and deploys tools of the philosophy of language to tackle the question whether a joke as a type can be considered morally flawed irrespective of its tokens. After exploring possible ways one can think of to furnish evidence for the opposite position, two novel lines of argumentation based on counterfactual conditionals and speech act theory are provided to show that these ways aren’t viable and that joke as types (even offensive jokes like sexist or racist ones) are ethically neutral. Moreover, the presented approach increases the resolution of the debate and provides a framework to capture other hitherto neglected questions of the philosophy of humor as well.
Personale Identität ohne Persönlichkeit? Anmerkungen zu einem vernachlässigten Zusammenhang
Authors: Meincke Anne Sophie
Published: September 2022

Abstract. Recent decades have seen an increasing tendency to exclude the phenomenon of personality from the metaphysical investigation of personal identity. We are advised not to confuse personal identity as a philosophical subject, namely as the metaphysical issue of specifying what it is that makes a person staying numerically identical over time, with the psychological question of ‘personal identity’ which asks what makes someone the individual person they are with their particular character and history. However, one might be unsatisfied with this. If (as common sense takes for granted) persons are to be conceived of as beings possessing a personality, should there not be some more than superficial connection between personality and personal identity in the philosophical sense? This paper investigates this question by revealing the guiding – metaphysical – assumptions behind the claim that personality and personal identity must be treated separately as well as by presenting the metaphysical alternative brushed aside by the adherents of this claim. In fact, so I argue, there are two opposing views of the relation between personality and personal identity, these being grounded in two opposing metaphysical models of what a person is: the substance model and the bundle model of the person. However, it turns out that ultimately both competing models fail for fundamental reasons, which raises the question of what a way out of the dilemma might look like.
Die Sache der menschlichen Freiheit in Schellings mittlerer Philosophie
Authors: Gerlach Stefan
Published: September 2022

Abstract: In the period of On the Essence of Human Freedom Schelling worked out a theory of freedom which includes more than its main question about the compatibility of human freedom to do good and evil with the logical necessity of reason and freedom of God. A full comprehension of freedom in this period has to include his answers to the question how free individual actions of persons work. The main claim of this paper is that Schelling’s philosophy around 1810 contains a two-level theory of freedom. It relates a fundamental base of general freedom and unchangeable decisions about our character with a level where different grades of freedom and changes of the character of a person are possible.
Eine transformative Konzeption der anthropologischen Differenz
Authors: Kietzmann Christian
Published: September 2022

Abstract. This paper offers a reevaluation of the debate between assimilationism and differentialism concerning the anthropological difference. Both sides usually assume that the difference consists in a capacity which humans possess and other animals lack, and that is added to a set of capacities humans share with other animals. A likely candidate for this role is reason. An additive conception of human reason on these lines runs into several difficulties, which can be avoided by thinking of reason transformatively, as providing human capacities with a special rational form. What such a transformative conception amounts to is described in some detail for the special case of human perception. A transformative understanding of reason’s role enables us to formulate a differentialist position that does not fall prey to the usual problems of differentialism.
Was heißt Denken? Die Herausforderung des Proslogion-Arguments
Authors: Pöltner Günther
Published: September 2022

Abstract. The Proslogion argument is often still considered as an ontological proof of the existence of God or as its predecessor. Doubtless this misinterpretation does not strike the root of the matter. Anselm requests to reflect upon what is and has always been present to reasoning in an unthematically way. Proslogion chapt. 2 reflects upon the difference between only being thought and being, and points out the characteristic feature of reasoning – to be the disclosure of being. Proslogion chapt. 3 reflects upon the difference between being as being and its origin. Id quo nihil maius cogitari potest is not the highest thinkable (summum cogitabile) but what is showing itself while withdrawing from reasoning.
Betroffenheit: Zur Konstitution responsiver Gemeinschaft jenseits von Recht und Gefühl
Authors: Alloa Emmanuel , Grosser Florian
Published: September 2022

Abstract. The paper aims at showing the potential of a phenomenologically informed approach for contemporary debates on democratic legitimacy and community. While the role of affectivity has recently been reconsidered in social and political theory, phenomenological insights into affective moments of subject- and community-formation can contribute to further methodological refinement. Inversely, it is suggested that phenomenological analyses on subjectivity and intersubjectivity should be broadened so as to include what often remained a blind spot: the political dimension. Drawing on descriptive resources offered by Levinas, Waldenfels, and Esposito, the paper sets off to rehabilitate the concept of Betroffenheit, of concernedness or being concerned, which, historically, was at the center of conceptions of democratic politics before being removed from it. Questioning its unreserved ‘juridization’, it is argued that an affective understanding of being concerned is relevant for re-describing the emergence of collective political agents: The shared response to an initial experience of being concerned opens up an alternative account of political processes that, venturing beyond issues of legitimacy and sovereignty, outlines the perspective of democracy out of shared concernedness.
Der frühe Buber und die Mystik
Authors: Jung Christian
Published: September 2022

Abstract. In his early years, before his dialogical turn, Martin Buber studied the mystical traditions of Europe and Asia and even considered himself a mystic of sorts. The present paper examines Buber's attitude towards mysticism in the course of his intellectual and personal development, particularly before and during his transitional phase to the philosophy of dialogue. The first section details the formative impact intellectual currents around 1900 had on Buber, focussing on the Neue Gemeinschaft of the Hart brothers in Berlin and Gustav Landauer. In a second step, Buber's concept of mysticism is subject to scrutiny. This is essential for understanding why he dissociated so vehemently from mysticism in his dialogical phase. The critique of mysticism in I and Thou is, therefore, the subject matter of the third and last section.
At forholde sig professionelt
Authors: Hammershøj Lars Geer , Henriksen Morten
Published: September 2022

The aim of the article is to present the concept professional Bildung and use it to throw light on the professionalism of the social educator. The assumption is that Bildung as a form of character formation will be highly relevant in the labor market in the future. Professional Bildung is a concept for this and is defined as the capacity to relate professionally in one’s work.  Based on a presentation of the concept, we analyze acts on educational aims and discussions of professionalism of the social educator. Furthermore, we analyze examples of relating creatively and innovatively as a social educator from project LegeKunst, which aims at promoting play and Bildung through art and culture. In the discussion, we argue that the professionalism of the social educator is exemplary for professional Bildung in the sense that the social educator relates to open situations and exercise judgment. Furthermore, the analysis of LegeKunst indicates that relating creatively and innovatively concerns the readiness of the social educator to play along and change his or hers educational practice. At the end, we compare these findings with the professionalism of the teacher, which appears to differ from the social educator in that teaching to a larger degree includes specific professional tasks and goals.
Dannelsesmarkører i håndværket
Authors: Skov Tobias Kidde
Published: September 2022

Through a reading of key concepts in The Craftsman by the American sociologist Richard Sennett, this article investigates if there are any clear connections between craft and Bildung in Sennett' work. Based on stories from The Craftman, this article analyzes three concepts (repetition, resistance and dialog) of craft as understandings of Bildung. The three concepts show an inherent educational potential, and that these potentials can be regarded as pedagogical possibilities, in technical vocational educations. Finally, the article discusses how the three concepts on craft as Bildung, could fit into the current educational practice of technical vocational educations in Denmark.
Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves
Authors: Chan Melanie MY , Sadeghi-Alavijeh Omid , Lopes Filipa M , Hilger Alina C , Stanescu Horia C , Voinescu Catalin D , Beaman Glenda M , Newman William G , Zaniew Marcin , Weber Stefanie , Ho Yee Mang , Connolly John O , Wood Dan , Maj Carlo , Stuckey Alexander , Kousathanas Athanasios ,   Genomics England Research Consortium, Kleta Robert , Woolf Adrian S , Bockenhauer Detlef , Levine Adam P , Gale Daniel P
Published: September 2022

Posterior urethral valves (PUV) are the commonest cause of end-stage renal disease in children, but the genetic architecture of this rare disorder remains unknown. We performed a sequencing-based genome-wide association study (seqGWAS) in 132 unrelated male PUV cases and 23,727 controls of diverse ancestry, identifying statistically significant associations with common variants at 12q24.21 (p=7.8 × 10−12; OR 0.4) and rare variants at 6p21.1 (p=2.0 × 10-8; OR 7.2), that were replicated in an independent European cohort of 395 cases and 4151 controls. Fine mapping and functional genomic data mapped these loci to the transcription factor TBX5 and planar cell polarity gene PTK7, respectively, the encoded proteins of which were detected in the developing urinary tract of human embryos. We also observed enrichment of rare structural variation intersecting with candidate cis-regulatory elements, particularly inversions predicted to affect chromatin looping (p=3.1 × 10-5). These findings represent the first robust genetic associations of PUV, providing novel insights into the underlying biology of this poorly understood disorder and demonstrate how a diverse ancestry seqGWAS can be used for disease locus discovery in a rare disease.
Traffic flow simulation of modified cellular automata model based on producer-consumer algorithm
Authors: Deng Xuefeng , Shao Yi , Song Jiaxin , Wu Hui
Published: September 2022

With the rise of new technologies such as the Internet of Vehicles and the Internet of Things, research on the intelligent connected vehicle has become a hot topic in contemporary times. The modeling and simulation of traffic flow are mainly used to analyze the characteristics of traffic flow and study the formation and dissipation mechanism of traffic congestion to better guide the real traffic. Cellular automata are suitable for the simulation of complex giant systems. Because of the randomness and discreteness of vehicle driving, cellular automata are often used to model and analyze traffic flow. This article mainly studies the traffic flow formed by intelligent connected vehicles. Based on the traditional NaSch model, the producer-consumer algorithm is introduced to form a multi-buffer vehicle information access mode, and an improved cellular automata model with random updates is constructed. The simulation results show that the improved cellular automata model improves the traffic congestion significantly compared with the original NaSch model in the intelligent network environment, which is consistent with the actual traffic situation. Therefore, the algorithm proposed in this article can effectively simulate the traffic flow characteristics of intelligent connected vehicles, and provide a theoretical basis for solving traffic problems.
Constitucionalismo societario y regímenes privados autoconstitucionalizados: aportes y mirada crítica
Authors: Cozza Saraiva Bruno , Marks Szinvelski Mártin
Published: September 2022

La sociedad ha alcanzado un grado de interdependencia no visto en los últimos tiempos. La tecnología y la economía han facilitado procesos evolutivos de especialización de los sistemas sociales. Por otro lado, como efecto inmediato, el Estado nacional pasó a experimentar los reflejos de la globalización y el debilitamiento institucional de un modelo de sociedad que se dirige fuera de los dominios territoriales. Se presenta como objeto de estudio y de interconexión entre la teoría del derecho constitucional y la de la sociología jurídica el surgimiento de los regímenes privados autoconstitucionales, en sustitución de las anteriores normas constitucionales estatales. En este contexto, el surgimiento de una nueva corriente teórica, denominada "sociología de las constituciones", se erige como un campo teórico fértil para llevar a cabo debates sobre el debilitamiento del Estado-nación y el surgimiento de modelos de normalización de vida distintos a los asociados a el Este modelo do-centrista. Las consecuencias en el derecho constitucional son relevantes, especialmente en la forma en que se pueden establecer y ejercer nuevos derechos. Como consecuencia de ello, se propone, como objetivos del presente estudio, promover la contextualización del fenómeno transnacional, asociado a las cuestiones democráticas que lo envuelven y, finalmente, evidenciar las principales características de la autoconstitucionalización de la vida privada. regímenes. Se utilizará la Teoría de los Sistemas Sociales de Luhmann como método para describir las diferencias y formas de observar las teorías trabajadas a lo largo del artículo. Como método de procedimiento se utilizará la técnica de investigación documental indirecta, con revisión de bibliografía nacional y extranjera.
Por qué es justo reconocer la representación especial de las minorías? Reflexiones del consenso traslapado en Rawls a la ciudadanía diferenciada en Young
Authors: Huertas-Hernández Sergio
Published: September 2022

Un asunto clave en nuestras sociedades democráticas es el principio de representación. Razón por la cual en países de todo el mundo se han establecido cuotas para minorías en la política electoral, haciendo más real la suposición de que en democracia todo ciudadano es libre de elegir y ser elegido al gozar de garantías durante los procesos electorales. No obstante, es frecuente observar la exclusión y vulneración de grupos sociales como los negros, las mujeres, minorías religiosas y étnicas, junto a las de género por su situación socioeconómica como por su identidad sociocultural. Por lo tanto, en este artículo se reflexiona en torno a por qué es justo reconocer y agregar los intereses de los grupos minoritarios en el ordenamiento jurídico de un país. Todo ello a partir de los planteamientos de justicia expuestos tanto en John Rawls como en Iris Marion Young. Es así como en las siguientes líneas se provee un marco analítico en el que confluyen los fundamentos del consenso traslapado con la idea de la ciudadanía diferenciada para reconocer la necesidad de una representación especial mediante leyes de cuotas electorales para las minorías.
El Frente Amplio chileno en punto cero: Inserción social y perfil de militancias dentro de la nueva izquierda chilena
Authors: Miranda Orrego Juan Pablo
Published: September 2022

Este artículo analiza la inserción en movimientos sociales y el perfil de los militantes del Frente Amplio chileno en el momento de su conformación en 2017 a través de testimonios recogidos por medio de entrevistas semiestructuradas. Los testimonios recogidos de militantes del Frente Amplio son contrastados con testimonios de militantes del Partido Socialista y Comunista de Chile, ambas organizaciones pertenecientes a la entonces coalición de gobierno. A través del análisis de las entrevistas se observa en la militancia del Frente Amplio una menor orientación hacia la administración del aparato público y una creciente inserción en movimientos sociales, en coherencia con la etapa incipiente de la coalición. No obstante, este artículo da cuenta de una inserción social y territorial percibida como superficial, dificultades dentro del conglomerado a la hora de compatibilizarla participación en espacios sociales e institucionales y dificultades para superar una identidad marcada por el movimiento estudiantil.
COVID-19 Infection in a Sickle Cell Anaemia Patient from Sudan
Authors: Muddathir Abdel Rahim Mahmoud
Published: September 2022

Sickle Cell Disease (SCD) is an inherited disorder with variable clinical presentation and low immunity. Coronavirus Disease-2019 (COVID-19)is a pandemic disease with a high-risk in chronic disease patients and older adults. SCD is widely distributed in Sudan; many SCD patients are infected with COVID-19. Despite this, no published data is available. This case report demonstrated the haematological and clinical course of a Sudanese sickle cell anaemia patient with COVID-19. A 20-year-old male patient was admitted to a hospital for 15 days. Demographic and clinical data were obtained from his medical records. A blood sample was taken at the time of admission and during hospitalisation. Tests were performed during admission, including Complete Blood Count (CBC), liver function test, renal function test, coagulation studies, viral screening, and urine general. The patient was diagnosed with COVID-19 using the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) test based on the nasopharyngeal swab and COVID-19 IgG and IgM using Enzyme Linked Immunosorbent Assay (ELISA) for the previous infection. The patient received intravenous fluids, antibiotics, analgesia, oxygen supplementation, and blood transfusion two times during hospitalisation, and there was no need for Intensive Care Unit (ICU) admission. The patient’s prognosis was good; he was discharged on day 16 with no symptoms and a negative result of the COVID-19 PCR test. A severe illness was expected because he was infected twice by COVID-19, the patient showed mild clinical symptoms with a good prognosis, so further studies are required to understand COVID-19 among Sudanese SCD patients.
The Role of Marginal Farmers' Farming Enterprises in Ensuring Household Food Security
Authors: Kobir Humayun , Kayess Md. Omar
Published: September 2022

The goal of this study was to ascertain how marginal farmers' farming operations impacted household food security. Additionally, efforts were undertaken to identify the challenges marginal farmers faced in attaining household food safety. Due to this, the study was carried out in three randomly chosen villages in the Rajbari district's Baliakandhi upazila. In these three communities, out of 500 marginal farmers, 26% of the populace was randomly selected. Data was acquired through direct interviews with marginal farmers between January 5 and February 20, 2009. The majority of marginal farmers (51%) fell into the medium group in terms of the contribution of farming enterprises to domestic food safety, while 37% fell into the low category. More over half of the family's food requirements were still unmet by the farming operations, which only met 40% of them annually. The biggest percentage of age (42%) of the four farming enterprise categories came from crops alone. Among the ten traits of the marginal peasants, the size of the farm and the yearly family income were positively connected, whereas the size of the family, the annual nutritional demands of the family, and cropping intensity practiced were negatively correlated. The remaining traits were not significantly correlated with how much farming operations contributed to household food security. Lack of suitable land for farming, poor training facilities, and ignorance of various facets of better farming enterprises were the main challenges marginal farmers faced in achieving household food security.
The Utility of Health and Wealth for HIV Patients on Antiretroviral Therapy in Kenya
Authors: Chacha Winnie , Akinyi Jane , Mwalili Samuel
Published: September 2022

Aims/ Objectives: To determine the appropriate utility function that models the trade o between health and wealth for HIV/AIDS patients on Antiretroviral Therapy in Kenya.

Study Design: Retrospective study.

Place and Duration of Study: Jomo Kenyatta University of Agriculture and Technology, between January 2019-April 2022.

Methodology: The study involved a retrospective study of 2800 patients on Antiretroviral Therapy in Kenya from the period of 2005-2017. All the records are in terms of random patient id and in no way is the privacy and anonymity of patients is compromised. The inclusion criteria is patients who had complete information on the covariates used in the model over the follow up period. The logarithmic utility function, the negative exponential utility function and the power utility function are compared using the Akaike Information Criterion to determine which one best fits the empirical data to model the health and wealth trade off of patients on Antiretroviral Therapy in Kenya.

Results: Women constituted 66% of the sample. Only patients over the age of 18 years were included in the study. The mean age was 40.3. The health related quality of life values were calculated for each patient on Antiretroviral Therapy using the proxy utility function approach. The costs associated with receiving Antiretroviral Therapy treatment were obtained from simulating from a gamma distribution with ranges from existing published literature. The logarithmic utility function had the least AKaike Information Criterion.

Conclusion: The marginal utility of health increases with wealth for People living with HIV and the logarithmic utility function is suitable for modelling the shape of preferences for the trade off between health and wealth for HIV patients on Antiretroviral Therapy.
Climatic Effects on Quality Parameters and Their Relationships of Bread Wheat Genotypes (Triticum aestivum L.) Grown under Semi-arid Region
Authors: Oktem Ayse Gulgun , Oktem Abdullah
Published: September 2022

Aims: This study was conducted to determine climatic effects to quality parameters of bread wheat genotypes grown in the semi-arid region.

Study Design: The experiment was carried out in a randomized complete block design with three replications. Thirty-three bread wheat genotypes (Triticum aestivum L.) were grown in a field trial and kernel samples analyzed for thousand kernel weight, test weight, protein content, wet gluten, dry gluten and SDS-sedimentation value.

Place and Duration of Study: The research was carried out during the 2008 and 2009 growing seasons at Sanliurfa, Turkey.

Methodology: For analyses 20 main spikes that contained fully developed kernels were chosen randomly from each plot and taken to the laboratory for analyses. The nitrogen content of kernels was determined using the Kjeldahl method and the result was multiplied by the factor 5.7 to calculate the protein content of kernels. Test weight and Sodium Dodecyl Sulphate (SDS)-sedimentation values were determined using standard procedures. Wet and dry gluten values were determined using a glutomatic system after separating gluten from the soluble starch and protein fractions.

Results: Genotypes were significant (P ≤ 0.01) for all tested characteristics. Thousand kernel weight ranged from 25.8 to 42.3 g, test weight from 73.7 to 81.7 kg hl-1, protein content from 9.7 to 14.8%, wet gluten from 28.5 to 42.2%, dry gluten from 9.4 to 14.1% and SDS-sedimentation value from 19 to 39 ml. Bezostaya-I, Kutluk-94, Altay-85, Harmankaya-99, Lirasa, Kirgiz-95 and Dagdas-94 genotypes had the best quality among tested genotypes in the semi-arid climatic conditions. Protein content was positively correlated with wet gluten, dry gluten and SDS-sedimentation value, respectively. Relationships were significant between wet gluten and both dry gluten and SDS-sedimentation value. A positive significant correlation was found between thousand kernel weight and SDS-sedimentation value and between dry gluten and SDS-sedimentation value.

Conclusion: Protein content, wet and dry gluten and SDS-sedimentation value were affected by climatic conditions of semi-arid region. Protein content, wet and dry gluten value were high but SDS-sedimentation value were low due to high temperature and low precipitation in semi-arid region.
Effect of Different Spacing and Nitrogen Levels on of Beetroot cv. Detroit Dark Red Quality Parameters under Telangana State Conditions
Authors: Gayathri Addula , Venkatalaxmi K. , Laxminarayana D. , Mallesh S. , Kumar B. Naveen
Published: September 2022

The aim of this paper was to establish the effect of different spacing and nitrogen levels on quality parameters of beetroot cv. Detroit Dark Red under Telangana state conditions. It was carried out during rabi season of 2020-21 at SKLTSHU, College of Horticulture, Rajendranagar, Hyderabad, India. The experiment was laid out in Factorial Randomized Block Design with sixteen treatments replicated thrice. Treatment consisted of four levels of spacing S1 (45cm ×15cm), S2 (30cm×15cm), S3 (30cm×10cm) and S4 (15cm ×15cm) and four levels of nitrogen N1 (70 Kg ha-1), N2 (87.5 Kg ha-1), N3 (105 Kg ha-1) and N4 (122.5 Kg ha-1). The effects of the spacing and nitrogen levels was observed for quality characters. Highest total soluble solids (TSS) (9.93 oBrix), reducing sugars (1.64%), total sugars (7.31%) and chlorophyll content 45.50 (SPAD value) were recorded in wider spacing S1- 45 cm x 15 cm and highest ascorbic acid content (10.09 mg 100g-1) was recorded in closer spacing S4-15 cm x 15 cm, whereas pH and titrable acidity were found to be non-significant. Highest pH (6.20), reducing sugars (1.52%), total sugars (7.29%), ascorbic acid content (10.06 mg 100g-1) were recorded in nitrogen level N1-70 Kg N ha-1, whereas highest TSS (9.79 oBrix), chlorophyll content 45.70 (SPAD value) were observed in nitrogen level N4-122.5 Kg N ha-1. The interaction effect on quality parameters was found to be non-significant.
Field Assessment of Insecticides as Well as Bio-Pesticides to Manage the Tomato Fruit Borer Helicoverpa armigera Hubner
Authors: Yadav Sneh , Pal R. K. , Yadav Ajay Kumar , Yadav Ankit Singh , Singh Gurwaan
Published: September 2022

A field experiment was conducted for the management of tomato fruit borer in the winter period of 2021-22 at the Vegetable Research Station of C.S.A. University, Kanpur. The current study assessed the effectiveness of some novel insecticides as well as bio-pesticides on the Azad T-6 cultivar of tomato crop. Our team used chemical insecticides such as Flubendiamide 39.35% S.C. (Suspension concentrate), Chlorantraniliprole 18.5% S.C. and Fipronil 5% S.C. and bio-pesticides viz. Spinosad 45% S.C., Helicoverpa armigera nuclear polyhedrosis virus (HaNPV) 2% A.S. (Aqueous suspension), Bacillus thuringiensis subsp. kurstaki (Bt) 5% W.P. (Wettable powder) and Neemarin 1500 ppm (parts per million) at their suggested quantity. The observations on the number of larvae were recorded from ten arbitrarily tagged plants in each plot treated with insecticides and bio-pesticides. It was recorded that Flubendiamide 39.35% S.C. @ 0.2 ml/lit was found to be the most efficient against the fruit borer larvae trailed by Chlorantraniliprole 18.50% S.C. @ 0.3 ml/lit in decreasing the larval population and displayed maximum percent decrease in fruit infestation over untreated control. Amongst the bio-pesticides, Spinosad 45% S.C. @ 0.2 ml/lit was found to be the maximum effective over untreated control. All the used insecticides and bio-pesticides in the existing field experiment were found to be superior to the control.
Estimation of Variability and Genetic Divergence in Greengram [Vigna radiata (L.) Wilczek] for Yield Characters
Authors: Udayasri Shika , Lavanya G. R. , Lal Gabriyal M.
Published: September 2022

The present investigation consists of 20 genotypes of Greengram including one check, which were grown in the Field Experimentation Centre of the Department of Genetics and Plant breeding, SHUATS, Prayagraj during Kharif 2021 following RBD with three replications. The data were recorded on 13 characters to study the amount of genetic variability, Genetic Advance, Genetic advance as percent mean in the greengram genotypes. Based on the mean performance genotype MODAL-L532 followed TOR-2 and SANGU-1972 were identified as best genotypes for seed yield per plant. High significant variation was obtained for all characters studies. High heritability estimates were observed for Number of primary branches, Seed yield, harvest index followed by number of pods per plant, number of secondary branches, biological yield, number of seeds per plant, number of seeds per pod,100 seed weight, days to 50% flowering, days to maturity, days to 50% pod setting, and plant height. High values for heritability indicates that it may be due to higher contribution of genotypic components. High genetic advance as percent of mean was recorded high for seed yield, harvest index, biological yield, number of pods per plant, number of primary branches, number of seeds per plant, number of secondary branches, number of seeds per pod, hundred seed weight, plant height, days to 50% flowering, days to 50% pod setting, days to maturity. Metroglyph analysis shows, analysis of variance indicated that significant variations among the 20 lines for thirteen characters. The scatter diagram revealed that three complexes couldbe distinguished on the basis of morphological variation. Maximum number of genotypes falls in cluster I (10) and II (9) followed by cluster III (1). The germplasm lines, OLTS-B2, MODAL-L532, S/9-1179, SLTS-B2, recorded high index score and fell into different clusters can be crossed to have maximum variability of good combination of characters. Thus, the use of these genotypes in future breeding programme is suggested.
Physico-Chemical Properties of Juice in Different Wine Varieties of Grape (Vitis vinifera L.)
Authors: Joshi Veena , Reddy S. Amarender , Rao B. Srinivas
Published: September 2022

Physico-Chemical properties of juice in thirteen wine grape varieties (eight coloured and five white) were evaluated  to assess the feasibility of growing wine grape varieties under Southern Telangana conditions. Observations recorded on physico-chemical properties of juice revealed that juice recovery was maximum in Chenin Blanc (78.38%) among the white varieties and in Pusa Navrang (77.75%) from the coloured ones. Total Soluble Solids (TSS) of juice in different varieties ranged from 15.43oB to 21.95oB .Maximum TSS was recorded in Cv. Shiraz followed by Cabernet Sauvignon while minimum content of was observed in Italia. The titrable acidity of juice ranged from minimum of 0.51% in Ruby Red to maximum of 0.92% in Chenin Blanc and all the varieties were found to be within the standard range as reported by Karibasappa and Adsule, 2008 i.e. (dry table wines require high acidity of 0.6 to 0.9%, while sweet dessert wines require 0.5 to 0.6% acidity). pH of the juice ranged from 2.96 (Italia) to 3.53 (Athens) which indicated that as per the pH norms, all the varieties screened are suitable for making wines except Italia. Highest total and reducing sugar content of juice was observed in Shiraz (19.28% and 15.38%) followed by Chenin Blanc (19.07% and 15.21%) and on the other hand, minimum total sugar content (13.14%) was recorded by Cv. Italia and reducing sugar content in Pusa Navrang (7.84%). The results signifies the potential `for cultivation of wine grape varieties under Southern Zone of Telangana.
An Assessment of Multidrug Resistant Bacterial Status of Ogane-Aji River, Anyigba, Kogi State
Authors: Adegoke S. A. , Yusuf L.
Published: September 2022

Surface aquifers can be useful for a variety of purposes, but they can also act as fomites. River water could be a major route of spread of disease causing and multidrug resistant bacteria. The multidrug resistance pattern of bacteria from the Ogane-Aji River was studied. The river water samples were collected at two different points namely, Point A (10 cm depth) and Point B (45 cm depth). Standard microbiological techniques were used to identify the bacterial isolate that was obtained. The disks agar diffusion method was used to examine the isolates for resistance to nine foreign antibiotics and 20 indigenous antibiotics.  These samples were analyzed by the most probable number (MPN) of which point B had more MPN index/ml (180) than point A which had 79 MPN/index/ml. The organisms most frequently isolated from the samples included those of the genera Staphylococcus, Bacillus, Enterobacter, Pseudomonas, Escherichia, Klebsiella, Streptococcus and Salmonella. Percentage resistance to all the foreign antibiotics by the isolates were obtained {Staphylococcus sp.(55.5%), Bacillus sp. (66.6%), Enterobacter sp.(77.8%), Streptococcus sp. (88.8%), Pseudomonas sp. (66.6%), E. coli, Klebsiella (77.8%), Streptococcus sp.(88.8%) and Salmonella sp. (88.8%) while percentage resistance to all the indigenous antibiotics were Staphylococcus sp.(30%), Streptococcus sp.(20%), Bacillus sp.(70%), Enterobacter sp. (60%), Pseudomonas (50%), E. coli (50%), Klebsiella (40%) and Salmonella (20%)}. It was discovered that every isolate was multidrug resistant. It is concerning for people's health that these organisms are present in this body of water, which is used for numerous things in the area. The river water could be a means whereby these etiologic agents and the multidrug resistance properties can spread through the population in contact with the river.
Nanoparticle Optical Sensor Arrays: Gas Sensing and Biomedical Diagnosis
Authors: Lu Xiaohui , Suslick Kenneth S. , Li Zheng
Published: September 2022

Chemical sensor arrays provide a simple but powerful means of creating detection specificity through pattern recognition of the responses from an array of highly cross‐reactive sensor elements. Optically responsive nanoparticles have emerged as a useful class of chemical sensors and enabled the development of real‐time, sensitive, cost‐effective and portable microdetectors for targeting biochemical analytes of interest. The unique and fascinating physicochemical properties of nanoparticles play a key role in building promising array‐based sensing platforms. This perspective will describe the principles, fabrication, and applications of various nanoparticle‐based optical sensor arrays. Choice of nanomaterials, optical signal transduction, array substrate and fabrication, as well as statistical data analyses will be elaborately discussed. As two major areas of applications, the detection of environmentally related volatiles and clinical use for biomedical diagnosis will be discussed in detail. Finally, the remaining challenges and future perspectives within this analytical topic will be highlighted.
Characteristics of homologous recombination repair pathway genes mutation in ovarian cancers
Authors: Yi Zongbi , Chen Min , Sun Shaoxing , Yang Chunxu , Mei Zijie , Yang Hui , Xiang Qingming , Qiu Hui
Published: September 2022

Background

Few studies have investigated the characteristics of non‐BRCA homologous recombination repair (HRR) pathway somatic mutations, and the impact of these mutations on efficacy of treatment in ovarian cancer patients is not clear. Therefore, we conducted this study to analyze the frequency and spectrum of somatic mutations in HRR pathway genes in patients with ovarian cancer and to examine the relationships between somatic mutations in HRR pathway genes and their effects on the efficacy of platinum‐based chemotherapy.

Methods

We performed targeted sequencing of 688 genes related to the occurrence, development, treatment, and prognosis of solid tumors. Somatic mutations were identified by paired analysis of tumor tissue and germline DNA in blood cells.

Results

A total of 38 patients with ovarian cancer were included in the study, and 35 (92.1%) patients were diagnosed with high‐grade serous carcinoma. All patients exhibited somatic mutations in the tumor tissue samples. The commonly mutated genes were TP53 (73.7%), BRCA2 (55.3%), NF1 (52.6%), BRCA1 (47.4%), and CDH1 (47.4%). Overall, 71.1% of the patients exhibited mutation in at least one HRR pathway gene. The most frequently altered HRR genes were BRCA2 (55.3%), followed by BRCA1 (47.4%), ATM (44.7%), BARD1 (42.1%), and CHEK1 (36.8%). The median progression‐free survival (PFS) in patients with HRR pathway mutation was 36.0 months compared with 13.6 months in patients with no HRR pathway mutation (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.08–0.77; p = 0.016). Patients harboring BRCA1/2 and/or CDK12 mutations displayed a longer PFS (median, 36.0 months) compared with patients with no BRCA1/2 or CDK12 mutation (median, 13.6 months; HR, 0.21; 95% CI, 0.07–0.61; p = 0.004). In multivariate analysis Cox proportional hazards models, after adjustment for tumor stage at diagnosis and histology of initial diagnosis, patients with HRR pathway mutation had a longer PFS than patients with HRR wild‐type genes (p = 0.006).

Conclusions

HRR pathway somatic mutations are common in Chinese patients with ovarian cancer. HRR pathway somatic mutations were associated with improved sensitivity to platinum‐based chemotherapy. Large‐scale prospective studies are needed to verify our findings.
Design of Unsteady‐State Fixed‐Bed Processes for Heat Regeneration, Ad‐/Desorption, and Gas‐Solid Reactions
Authors: Kern Christoph , Jess Andreas
Published: September 2022

This review covers all three unsteady‐state fixed‐bed processes important in chemical engineering, namely, heat transfer from a hot gas to a cold fixed bed (heat regenerator), ad‐ and desorption of a gas for a Langmuir and a linear isotherm, and regeneration of a coked catalyst by coke burn‐off as an important example of a transient gas‐solid process. Albeit of inherent differences, the processes have strong analogies. For example, a moving heat or mass transfer zone, spreading or with constant pattern behavior, is formed. For each case, numerical and suitable analytical solutions for process design either selected from literature or developed in this work are derived and compared. Experimental data, if available, are also considered.
ALK‐rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors
Authors: Dermawan Josephine K. , DiNapoli Sara E. , Mullaney Kerry A. , Sukhadia Purvil , Agaram Narasimhan P. , Dickson Brendan C. , Antonescu Cristina R.
Published: September 2022

Anaplastic lymphoma kinase (ALK) fusions are oncogenic drivers in diverse cancer types. Although well established in inflammatory myofibroblastic tumor (IMT) and epithelioid fibrous histiocytoma (EFH), ALK rearrangements also occur in the emerging family of kinase fusion‐positive mesenchymal neoplasms. We investigated 9 ALK‐rearranged mesenchymal neoplasms (exclusive of IMT and EFH) arising in 6 males and 3 females with a wide age range of 10 to 78 years old (median 42 years). Tumors involved superficial and deep soft tissue (6) and viscera (3). Three were myxoid or collagenous low‐grade paucicellular tumors with haphazardly arranged spindled cells. Three were cellular tumors with spindled cells in intersecting short fascicles or solid sheets. Three cases consisted of uniform epithelioid cells arranged in nests or solid sheets, with prominent mitotic activity and necrosis. Band‐like stromal hyalinization was present in 6 cases. All tumors expressed ALK; four were positive for S100 and five were positive for CD34, while all were negative for SOX10. By targeted RNA sequencing, the breakpoints involved ALK exon 20; the 5′ partners included KLC1, EML4, DCTN1, PLEKHH2, TIMP3, HMBOX1, and FMR1. All but two patients presented with localized disease. One patient had distant lung metastases; another had diffuse pleural involvement. Of the six cases with treatment information, five were surgically excised [one also received neoadjuvant radiation therapy (RT)], and one received RT and an ALK inhibitor. Of the four patients with follow‐up (median 5.5 months), one remained alive with stable disease and three were alive without disease. We expand the clinicopathologic spectrum of ALK‐fused mesenchymal neoplasms, including a low‐grade malignant peripheral nerve sheath tumor‐like subset and another subset characterized by epithelioid and high‐grade morphology.
The effect of virtual reality therapy and counseling on students' public speaking anxiety
Authors: Sarpourian Fatemeh , Samad‐Soltani Taha , Moulaei Khadijeh , Bahaadinbeigy Kambiz
Published: September 2022

Background and Aims

One of the barriers to effective communication between speaker and listeners is public speaking anxiety (PSA). Over recent years, PSA has become common among students as the most widespread social anxiety (SA). Virtual reality (VR) and counseling therapy help reduce PSA. Therefore, the present study aimed to investigate the effect of VR therapy and counseling on students' PSA and SA.

Methods

This quasi‐experimental study was conducted on 30 students at three levels of undergraduate, postgraduate, and PhD at Kerman University of Medical Sciences and Shiraz University of Medical Sciences (15 students in the intervention group and 15 in the control group). The intervention group observed four virtual classroom scenarios in a 30‐min session, and the control group attended a 90‐min group counseling session. Data were collected using by Personal Report of Public Speaking Anxiety, Liebowitz Social Anxiety Scale, and Igroup Presence Questionnaire. The data analysis was done using SPSS version 21. Descriptive analysis (frequency and percentage, mean, standard deviation, and quartiles) and analytical tests (paired t‐test and independent t‐test) were used to analyze the data.

Results

The results showed that VR and counseling did not affect SA scores and statistical differences before and after the intervention were not statistically significant. However, VR and counseling reduced PSA. The mean of IPQ/IGP (physical presence) was 63.73. The participants' SA means (93.76) were higher than the mean PSA (73.4).

Conclusions

VR and counseling did not affect students' SA, but they reduced PSA. If the intervention duration in future studies are longer, the effect of VR and counseling on reducing SA is likely to become more apparent.