bluuebunny/crossref_metadata_2025 huggingface dataset:
Daylight, Solar Radiation, Architectural Expression, and Energy Efficiency of Buildings
Authors: Solovyov Alexei K.
Published: January 2022

Building design includes a large number of various issues, which must be taken into account in mutual coordination and with optimal consideration of individual factors. Daylighting, insolation, sun protection in hot weather are factors that directly affect the comfort of the indoor environment in buildings and their energy efficiency. It is noted that the above factors also affect the economy through the cost of housing and through operating costs for replenishing heat losses through windows, for ventilation and cooling of buildings, i.e. on the elimination of heat gains through translucent structures, as well as on artificial lighting, for which electricity costs can be comparable depending on the climatic conditions of the construction site and the design features and architecture of buildings, on artificial lighting technology and on technical solutions for air conditioning and ventilation. It provides topics related to daylight, solar radiation, and translucent structures, directly related to building design, partially reflected in the articles of this issue of Light & Engineering journal. Thus, the interrelation of building design issues with various aspects of lighting technologies is indicated.
Holographic Optical Elements: Advantages and Disadvantages for Efficient Lighting, Sun Protection, and Photovoltaic Power Supply of Buildings
Authors: Solovyov Alexei K. , T. Pham Hong-Tham
Published: January 2022

The research of holographic optical elements (HOE) was carried out very intensively in the 1980s and 1990s. They provided great advantages in high-efficiency natural light, while at the same time providing effective sun protection and did not disturb the free view from the windows. The light-directing qualities of these devices made it possible to concentrate direct and scattered solar energy on photovoltaic batteries and solar collectors for hot water supply and solar heating. However, in recent years, research in this area has become less and less frequent without any explanation. The analysis of the research carried out in the framework of one of the latest projects carried out on behalf of the European Commission under the program “Energy, Environment, and Sustainable Development” (EU Contract Number: ENK6-CT‑2000–00327) with the participation of nine research organizations, higher schools, and universities is presented. The role of each of the participants in this interdisciplinary project was to attract experienced researchers in various fields of science and use their knowledge to obtain an objective result.
Luminaires and the History of the Development of Artificial Lighting in Russia
Authors: Solovyov Kirill A.
Published: January 2022

The article is devoted to luminaires and the history of the development of artificial illumination. As you know, light is one of the human needs. At all stages of the development of human civilization, people have thought about how to use artificial light source if there is not enough daylight. That is why man constantly invented and improved certain light source, the framings of which we now call lighting device or luminaires. The stages of development and improvement of luminaires are a matter of separate serious scientific research. In this article, we are talking about how the development of lighting devices took place in different periods. In different epochs, luminaires corresponded to certain traditions and aesthetic views of certain architectural styles. That is why in his article the author pays great attention not only to the appearance of the described luminaires, but also to its architectural environment.
Психологічна програма розвитку особистісних детермінант вибору ефективних копінг-стратегій учасників операції Об’єднаних Сил на етапі декомпресії
Authors: Yarmolchyk Maria
Published: January 2022

Мета статті полягає в розкритті особливостей проведення заходів психологічної програми розвитку особистісних детермінант вибору копінг-стратегій. Запропоновано структуру проведення основних етапів психологічної роботи. Проаналізовано особливості проведення занять, основні методи та техніки роботи з учасниками операції об’єднаних сил. У дослідженні використано наступний психологічний інструментарій: арт-терапії: музикотерапія, ізотерапія, пісочна терапія, техніки візуалізації, психоедукація, тренінгові заняття, консультування. Дослідження було проведене з 60 респондентами під час проводження психологічної програми розвитку особистісних детермінант вибору ефективних копінг-стратегій на етапі декомпресії, після тривалого перебували в зоні проведення операції Об’єднаних Сил. Визначено, що опрацьовуючи кожен етап, військовослужбовці проходять комплексне психологічне відновлення, що дає змогу продовжувати проходження військової служби та виконання завдань за призначенням. При проведенні психологічної програми виделено наступні сфери особистості, які відіграють важливу роль у виборі ефективних копінгів: емоційно-регулятивна, ціннісно-нормативна, особистісно-рефлексивна, соціально-адаптивна. Запропонована програма реалізовувалась через ряд заходів, які проводились з респондентами під час проходження ними декомпресії за встановленим графіком і розпорядком. Запропонована програма активізує особистісні риси військовослужбовців, які виступають ресурсом для вибору копінг-стратегій. Завдяки виявленню особистісних детермінант вибору копінг-стратегій, військовослужбовці можуть частіше використовувати копінги більш ефективні  у боротьбі зі стресом, водночас рідше – копінги пасивного пристосування до стресу.
EU-Russian Relations and the Eastern Enlargement: Integration or Isolation
Authors: Bharti Mukesh Shankar
Published: January 2022

Initially, in the first half of the 1990s, Russia’s plans to include the countries of the former Eastern bloc within the EU were not seen as a threat to its interests. Furthermore, in the context of NATO’s enlargement, some Russians regarded them as an advantageous alternative. Russia is aware that the EU enlargement with the Central and Eastern European states resulted in a present increase in the number of EU members supporting close trans-Atlantic relations. Moscow’s fears of further EU enlargement were softened due to a dispute that continues to grow within the Union, regarding the rationale and limits of further enlargement, primarily for the Balkan states, Turkey, and the CIS states. Moscow expects that the reluctance of European societies towards further enlargement will inhibit this process.

The external relations dimension of the European Union's enlargement to Central and Eastern Europe has received surprisingly little attention despite the fact that in the long‐term the issues it raises may be far more important than those currently dominating the debate. Nowhere is this more likely to be correct than about Russia, for which the EU's enlargement poses a risk of increasing isolation from the rest of Europe. The danger of creating a new dividing line across Europe is widely recognised, and the challenge, therefore, is to find ways of ensuring that Russia can be fully integrated with Europe while almost certainly remaining outside the EU Itself. This article focuses on relations between the EU and Russia and addresses three fundamental questions: how Russia has responded to the prospect of the EU's eastern enlargement; the specific issues arising from expansion, and the kind of long‐term relationship that could develop between Russia and an enlarged EU.
Актуальні питання забезпечення процесів планування оперативно-службової Державної прикордонної служби України
Authors: Bratko Artem , Datskov Anton , Bereziuk Viktor
Published: January 2022

В статті авторами проаналізовано та надано рекомендації, щодо процесів планування оперативно-службової діяльності Державної прикордонної служби України. Концептуальними і стратегічними документами держави визначено зміни щодо застосування сил прикордонного відомства в сучасних умовах. Існуючі форми оперативно-службової діяльності набувають нового змісту. На Державну прикордонну службу України, як правоохоронний орган спеціального призначення, покладаються нові завдання щодо захисту державного кордону. У зв’язку з цим система управління Державної прикордонної служби України зазнає суттєвих змін. Розширюється коло завдань резервів Державної прикордонної служби України. Створюються мобільні, ефективні, оснащені сучасним озброєнням, військовою та спеціальною технікою прикордонні Спеціальні сили, що будуть забезпечувати своєчасне реагування на виклики та загрози прикордонній безпеці України, використовуючи раціонально наявний потенціал (спроможності). Постає нагальна необхідність сумісності системи планування з системою, яка прийнята у Збройних Силах України та НАТО на основі спроможностей. Запровадження в діяльність Державної прикордонної служби України планування оперативно-службової діяльності на основі спроможностей дасть змогу значно покращити якість планування, підвищити здатність Державної прикордонної служби України до виконання завдань в сфері забезпечення безпеки державного кордону. Виконання даних заходів, спільно з іншими складовими сектору безпеки та оборони, забезпечить активну участь України в реалізації Спільної безпекової та оборонної політики ЄС та співробітництві з НАТО для забезпечення виконання вимог набуття повноправного членства в Північно-Атлантичному Альянсі.
Viabilidade econômica do sistema cage-free para poedeiras comerciais
Authors: Taborda José Valmir da Silva , Silva Vanessa Karla , Sgavioli Sarah
Published: January 2022

Com a crescente preocupação do mercado consumidor de alimentos com o bem-estar animal, o setor da avicultura, principalmente na produção de ovos, está sendo forçado a migrar para sistemas alternativos de produção. Com o intuito de auxiliar os produtores na tomada de decisão de investimentos, objetivou-se realizar um estudo de caso e avaliar a viabilidade econômica da implantação de um projeto para a criação de poedeiras no sistema cage-free, desde a construção do galpão até a venda dos ovos. Para isso foi feito o levantamento dos custos para a construção civil da instalação (15m x 150m), aquisição de equipamentos e custos relacionados com a produção os ovos, desde a compra das aves (15.750 aves da linhagem Dekalb brown), ração, vacinas, entre outros. Após a análise dos dados, estes foram submetidos à aplicação dos indicadores financeiros: valor presente líquido, taxa interna de retorno, paybacks simples e descontado e os pontos de equilíbrio: financeiro, contábil e econômico. Para as análises as condições propostas foram: custo de oportunidade 10%, lucro desejado de 15% e tempo para recuperação do investimento num período projetado de sete anos. Obteve-se um payback simples de 4,25 e o composto de 5,8 anos, valor presente líquido de R$ 141.504,37, o que gerou uma taxa interna de retorno de 14,33% e os percentuais sobre as vendas foram de 49,38%; 35,92% e 90,46% para os pontos de equilíbrio contábil, financeiro e econômico respectivamente. Conclui-se que, dentro do que foi proposto, a criação de poedeiras no sistema cage-free é viável financeiramente.
Influence of the endodontic access cavity design and restorative technique on hard tissue removal and fracture resistance of mandibular premolars
Authors: Boscatto Regina Helena , Prado Maira , Silva Emmanuel João Nogueira Leal , Lima Carolina Oliveira de , De-Jesus-Soares Adriana , Frozoni Marcos
Published: January 2022

This study assessed the influence of traditional (TradAC) and conservative access (ConsAC) with different restorative techniques on the percentage of hard tissue removed (%HTR) and on the fracture resistance of mandibular premolars. 45 premolars were scanned in a micro-computed tomography and assigned into four groups according to access (TradAC or ConsAC) and restorative technique: composite resin (CR) or fiber post (FP) + CR. After post preparation, the teeth were rescanned to determine the volume enlargement and %HTR from the crown and root canal. After restoration, the load at fracture was recorded. Data were analyzed statistically by one-way ANOVA and Tukey’s post-hoc test, ANOVA repeated measure, and chi-square tests (P<0.05). TradAC (RC or FP) resulted in the increase (Δ%) of root canal volume and hard tissue removed up to 14 mm (%) in comparison with ConsAC (RC or FP). TradAC + FP removed a greater percentage of hard tissue from the crown when compared to TradAC + CR. The percentage of hard tissue removed in the crown in the ConsAC groups was statistically lower than in the TradAC groups. The control group showed higher fracture resistance than all experimental groups, with no differences among the latter. Restorable fracture patterns were more prevalent. Traditional endodontic access cavities removed a higher percentage of dentine than conservative endodontic access cavities. However, no differences in fracture resistance were observed. Restorations using composite resin or fiber post associated with composite resin showed similar results of fracture resistance.
Acaricide activity of Piper macedoi Yunck essential oil against Rhipicephalus sanguineus
Authors: Bezerra Veridiane Marques , Ferreira Emília Gabriela Santos , Santos Gildásio Warllen dos , Oliveira Gisele Lopes de , Moreira Davyson de Lima , Vieira Thallyta Maria , Duarte Eduardo Robson , Deus Rodrigo Guimarães de , Lima Matheus Ramalho de , Roner Marcia Nunes Bandeira
Published: January 2022

This study evaluated the acaricide efficacy of Piper macedoi essential oil on larvae of ticks of the species Rhipicephalus sanguineus. The essential oil was extracted by hydrodistillation in a Clevenger-type apparatus. The test consisted of six treatments: from the group I to IV, samples corresponded to different concentrations of essential oil (500 μg.mL-1; 250 μg.mL-1; 100 μg.mL-1 and 50 μg.mL-1) diluted in Tween 80 at 2%. Groups V and VI corresponded to the negative controls (with distilled water and Tween 80 to 2%) and the positive control (with acaricide Amitraz at 12.5%), respectively. The essential oil was rich in apiole (39.81%) and dillapiole (26.47%). The essential oil of P. macedoi presented an activity against the larvae of R. sanguineus, with a better efficiency observed for concentrating 500 μg.mL-1, mortality of 80.67%, indicating a dose-dependent response.
Perfil epidemiológico das internações por transtornos mentais e comportamentais devido ao uso de álcool no município de Patos de Minas, Minas Gerais
Authors: Fonseca Laize Rodrigues da , Ribeiro Barbara Dayane , Silva Camila Adriane Almeida , Santos Eduarda Rocha , Silva Fabiana de Souza , Brandão Lara Fernanda Papalardo , Oliveira Laura Santos , Santos Sara Claudino dos
Published: January 2022

Introdução: O uso abusivo de álcool possui efeito nocivo em diversas fases da vida, gerando transtornos mentais e comportamentais de suma importância. Aliado a isso, há um número exorbitante de indivíduos que ingerem álcool com frequência e podem ou não resultar em um uso abusivo. Diante disso, dados atuais demonstram a elevada mortalidade associada ao uso nocivo de álcool o que gerou muitas dúvidas sobre qual seria o perfil dessa população. Objetivo: identificar os aspectos envolvidos na epidemiologia do uso nocivo de álcool no município de Patos de Minas. Metodologia: O presente trabalho consiste em um estudo epidemiológico descritivo, retrospectivo com abordagem de natureza quantitativa. Foi realizada uma pesquisa de dados no Departamento de Informática do Sistema Único de Saúde (DATASUS), analisando todos os casos de internações por transtornos mentais e comportamentais devido ao uso de álcool no município de Patos de Minas (MG), compreendidos entre o período de 2010 a 2020. Discussão: A parcela mais expressiva da população foram os homens, em idade economicamente ativa. Esse fato evidencia o perfil epidemiológico mais prevalente, mesmo havendo uma relativa subnotificação. Considerações finais: Tendo em vista o perfil epidemiológico mais expressivo, fazem-se necessárias ações educativas em saúde que visem modificar esse painel epidemiológico e mitigando o aumento de casos e possíveis riscos.
The use of ultrasonography as a tool to evaluate the quadriceps muscle in patients with chronic obstructive pulmonary disease: a systematic review
Authors: Santos Thais Angélica Bobalo dos , Santos Paula Motta dos , Wassmuth Talita , Mazzo Débora Melo , Costa Bruno Margueritte , Moleta Jeanny Franciela Kos
Published: January 2022

Abstract: The aim of this review is to understand the feasibility and potential clinical utility of US in measurements of the quadriceps muscles in patients with COPD. A total of 217 studies were identified and after applying the inclusion criteria, 12 were selected. The data were systematically searched by two independent reviewers. Of the included articles, five evaluated the maximal voluntary contraction of the quadriceps muscle and the Transverse Section Area (TSA) measured by US, of these, 4 found a remarkably reduced strength in COPD and in one article, it was described that this reduction occurs in all grades of the disease. Moreover, the greater the thickness of the quadriceps, the greater the maximum voluntary contraction of this musculature, however, the TSA is reduced in these patients when compared to healthy individuals. Thus, it is suggested that the AST, evaluated by US, can be used to assess the presence and/or severity of musculoskeletal dysfunction in these patients. The sonographic evaluation of the quadriceps in patients with COPD may provide a safe, effective, low-cost, reliable and reproducible evaluation, allowing the identification and monitoring of peripheral muscle dysfunction in this population, even when compared with other strategies.
Uso de metodologias ativas no ensino de enfermagem durante a pandemia pelo COVID-19: uma revisão integrativa
Authors: Lôbo Ana Luiza Souza de Faria , Santos Amuzza Aylla Pereira dos , Comassetto Isabel , Farias Mariana Maria Pereira Cintra , Silva Nathalia Lima da
Published: January 2022

O objetivo deste artigo investigar o que tem sido produzido sobre Metodologias ativas em tempos de pandemia, no contexto do ensino em Enfermagem, através de uma revisão integrativa de literatura. Metodologia: trata-se de um estudo qualitativo, com abordagem descritiva e retrospectiva, realizado através de uma revisão integrativa da literatura, estudo com coleta de dados realizada a partir de fontes secundárias, no período de junho de 2021. Resultados: utilizando a Biblioteca Virtual em Saúde (BVS) foram selecionados 05 para compor a amostra deste estudo. Sendo assim, destacamos que 3 eram estudos em português e 2, em inglês. O período de publicação entre 2020 e 2021.  Discussão: após análise dos artigos surgiram duas categorias para melhor apresentação do conteúdo. Sendo elas: Utilização de metodologias ativas, estratégias de ensino e tecnologias no contexto de pandemia; e Desafios e obstáculos da modalidade remota para o ensino em Enfermagem durante a pandemia.  Conclusão: é notório que o tema é uma crescente entre o meio acadêmico, pois envolve discente e docentes, que são peças fundamentais para aplicação e melhoria da metodologia a ser utilizada em sala de aula virtual.
A relação entre a utilização de cigarros eletrônicos e doenças pulmonares: uma revisão integrativa
Authors: Martin Maria Fernanda Okuyama , Natário Juliana Amorim Alfaix , Corrêa Gabrielle Ortiz , Ritter Guilherme Pazinato , Gouvea Neto João Luiz , Oliveira Laís Regina , Barboza Laura Loureiro , Castro Neto Bernardo de , Carvalho Sandy Carolline Marques , Abrahão Natália Melo
Published: January 2022

Cigarros eletrônicos (CE) têm sido considerados por jovens e adultos, uma nova forma de lazer e ainda, uma alternativa para substituição dos cigarros convencionais e, por conta disso, têm chamado a atenção de diversas indústrias para sua fabricação. Porém, pouco se sabe, ainda, sobre seus reais malefícios. O objetivo deste trabalho foi descrever a relação entre o consumo de cigarros eletrônicos e as doenças pulmonares. O presente estudo apresenta-se como sendo uma revisão integrativa da literatura de natureza básica do tipo descritivo e qualitativo. Muitos autores acreditam que o cigarro eletrônico seja capaz de substituir os cigarros convencionais gradativamente, visto que seus malefícios são menores. Entretanto, outros cientistas acreditam que seus malefícios são diversos e que sua potencial nocividade é desconhecida, pois não se conhece a fundo ainda seus reais efeitos sob longa exposição e sua complexa estrutura, principalmente devido às inúmeras possibilidades na fabricação dos e-líquidos. Diversos autores já alertam sobre os riscos ao pulmão, principalmente com relação a EVALI e suas manifestações, acreditando que os CE podem inclusive, levar usuários a morte. Sob o ponto de vista lesgislativo, sua comercialização e propaganda ainda são proibidos. Mais pesquisas são necessárias para que se possa entender a fundo sobre suas consequências, limites da constituição do e-líquido, características do usuário e padtões e políticas de uso.
Sistematização da assistência de enfermagem à gestante no centro cirúrgico obstétrico: potencialidades e desafios
Authors: Araújo Karla Brandão de , Aguiar Andresa Thamiris Rodrigues de , Marques Cintia Daniele Sousa , Santos Elisangela Siqueira dos , Rabelo Renata Sully dos Reis , Pereira Rogério Gomes , Lobo Maria José Guimarães , Jacinto Regina Racquel dos Santos
Published: January 2022

Objetivo: Investigar as evidências científicas sobre a assistência de enfermagem à gestante no centro cirúrgico obstétrico instrumentalizada pelo Processo de Enfermagem. Método: Foi realizado uma revisão integrativa da literatura consultando as bases de dados BDENF, LILACS e SciELO através da Biblioteca Virtual em Saúde e site oficial da SciELO. Foram utilizados os descritores controlados e não controlados: centro cirúrgico, gestante, centro cirúrgico obstétrico, gravidez, gestação de alto risco, processo de enfermagem e sistematização da assistência de enfermagem. Para formulação da estratégia de busca, os descritores foram combinados entre si com uso dos operadores booleanos AND e OR. Da elegibilidade, foram incluídos estudos primários, disponíveis online, em português e inglês, considerando o recorte temporal de 2016 a 2020 e excluídas teses, manuais, monografias, dissertações, editoriais, guias de prática clínica e revisões. Resultados: Foram selecionados seis artigos que revelaram que o enfermeiro reconhece a importância da aplicação do processo de enfermagem, porém alega falta de tempo pela sobrecarga de trabalho para sua concretização. Considerações Finais: foi percebido lacuna nas publicações quanto a temática da aplicação da sistematização da assistência de enfermagem no centro cirúrgico obstétrico, fato que corrobora para o fomento de futuros estudos sobre o assunto.
Megabacteriose aviária: breve revisão
Authors: Silva Cristiane Santana , Lallo Maria Anete , Bentubo Henri Donnarumma Levy
Published: January 2022

Megabacteriose constitui designação genérica aplicada a uma importante doença infecciosa aviária, inicialmente diagnosticada em periquitos, canários e avestruzes, mas que nos últimos anos tem sido observada em outras espécies, como mamíferos. Apesar dos esforços da ciência, a classificação taxonômica do microrganismo causador da desordem ainda não está bem estabelecida. A existência de indivíduos assintomáticos sugere que os reservatórios naturais desempenham um importante papel na disseminação da infecção e contribui para a controvérsia a respeito do papel do microrganismo como um patógeno primário. Inúmeras técnicas têm sido experimentalmente testadas no sentido de produzir maior sensibilidade e especificidade para o diagnóstico da doença. Embora a proventriculite não seja exclusivamente causada por Macrorhabdus ornithogaster, ela costuma ser o sinal clínico mais comumente associado à megabacteriose. Aparentemente, os macrolídeos poliênicos tem sido empregados com sucesso no tratamento da doença. Contudo, novos estudos devem ser estimulados para que esses aspectos sejam devidamente esclarecidos promovendo, assim, consenso entre clínicos e laboratórios.
Extrapulmonalis többszervi károsodás és funkciózavar Covid-19-ben
Authors: Kékes Ede , Nagy Judit
Published: January 2022

A SARS-CoV-2 vírus nemcsak a tüdőt támadja meg, hanem számos más szervet (szív, vese, máj, gyomor-bél traktus, pancreas, agy, vérképzés) és szabályozórendszert (RAAS, immunrendszer) is különböző mértékben és különböző patomechanizmussal. Ennek megfelelően sejtpusztulás, szövetkárosodás, illetve az egyes szervek funkciózavara vagy akár elégtelensége alakul ki. Közleményünk az extrapulmonalis károsodások gyakoriságát, a klinikai megnyilvánulásokat és azok hátterében álló patomechanizmusokat részletesen elemzi. Ezen sokszervi károsodás elsősorban a súlyos Covid-esetekben fordul elő, de mérsékelt vagy enyhe lefolyású esetekben is megjelenhet. Számolni kell azzal is, hogy a következmények az akut szakasz után, szeronegatív állapotban - hónapokkal a fertőzés kezdete után - is felléphetnek. Kiemelten a szív (myocarditis, coronariaelégtelenség, ritmuszavar), a vese (akut veseelégtelenség, majd tartós GFR-csökkenés), a glükózanyagcsere zavara (diabetes romlása, új diabetes kialakulása, ketoacidosis) okozza a legnagyobb terápiás kihívást. A sokszervi károsodás hátterében a direkt vírus okozta sejtpusztulás, a vascularis rendszerben végbemenő endothelialis sejtkárosodás és thromboinflammatio microthrombusok kialakulásával, a RAAS szabályozórendszer egyensúlyzavara és korai és késleltetett kóros immunválasz (citokinvihar) áll.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI EFEKTIVITAS INSPEKTORAT JENDERAL KEMENTERIAN DALAM NEGERI DALAM PENGAWASAN PENYELENGGARAAN PEMERINTAHAN DAERAH
Authors: Siregar Abel Rizky , Salomo Roy Valiant
Published: January 2022

This study aims to analyze the factors affecting the effectiveness of the Inspectorate General of the Ministry of Home Affairs in the supervision of the administration of local governance. This research uses the post-positivism paradigm with qualitative research methods. In-depth interviews and document studies were conducted to obtain the necessary data and information. The results of this study explain that the factors affecting the effectiveness of the Inspectorate General of the Ministry of Home Affairs in supervision the administration of local governance include structure, systems, strategy, style, staff, skills, and shared values. This is certainly by the elements contained in the 7S Mckinsey model that researchers use as a knife analysis in answering research questions. The results of the analysis revealed that the institutional structure was not yet matched, the still weak laws and regulations related to the supervision of the regional government, business processes were running well but the use of information technology was needed in building the supervision system, there was a need to strengthen planning to meet the needs of APIP to be met both in terms of the number and competence as well as the leadership style of the highest leadership is very participatory, democratic and can certainly support the development of existing work culture to increase the effectiveness of the Inspectorate General of the Ministry of Home Affairs in supervision the administration of local governance. 

Keywords: effectiveness, supervision, the administration of local governance
KEBIJAKAN PEMERINTAH DALAM PENANGGULANGAN KEMISKINAN DI KABUPATEN MUSI RAWAS
Authors: Hartawan Hartawan
Published: January 2022

This study attempts to look at attentively the local government of kabupaten musi rawas with an organization device was over all the country policies in the preparation of the issuing of the direction of poverty reduction programs .The results of research that is chronic: poverty caused: ( 1 ) a posture and habits of the lives of the community that is unproductive; ( 2 ) the limited means and their isolation; and ( 3 ) low level of the economic situation of education and of health care , the limited job opportunities , the community and helplessness , and poverty while caused ( 1 ) amendments to the economic cycle than in the normal situation be the economic crisis; ( 2 ) seasonal change by poverty such as the cases of food crops; and ( 3 of natural disaster or impact of a policy
ANALISIS KELAYAKAN PEMBENTUKAN DESA DI KABUPATEN INDRAMAYU
Authors: Tarigan Meliasta Hapri
Published: January 2022

Penataan Desa dapat dilakukan dengan pembentukan Desa yang merupakan tindakanmengadakan Desa baru di luar Desa yang ada. Pembentukan Desa mempersyaratkansejumlah kriteria yang harus dipenuhi, dan mekanisme yang melibatkan banyak pihak mulaidari masyarakat Desa sendiri, Pemerintah Desa, Pemerintah Daerah Kabupaten Kota,Provinsi dan Pemerintah Pusat. Tujuan penataan Desa diantaranya adalah untukmewujudkan efektivitas penyelenggaraan pemerintahan Desa, dan Mempercepatpeningkatan kesejahteraan masyarakat Desa Hasil kajian potensi Desa yang ada diKabupaten Indramayu, terdapat 69 Desa yang ada pada 27 kecamatan dari 31 kecamatanyang ada, layak untuk dimekarkan. Perlu tindak lanjut untuk rencana pembentukan desabaru menurut skala prioritas Daerah.
EFEKTIVITAS PENERAPAN E-KINERJA DALAM MENINGKATKAN KINERJA APARATUR SIPIL NEGARA PADA BADAN KEPEGAWAIAN DAERAH PROVINSI SULAWESI UTARA
Authors: Lembong Renald Christo , Lukman Sampara , Madjid Udaya
Published: January 2022

Dalam rangka meningkatkan kinerja aparatur dan kompetensi Sumber Daya Manusia serta menumbuhkan kreativitas dan inovasi kerja yang lebih tinggi pada pegawai sehingga Provinsi Sulawesi Utara menerapkan sebuah aplikasi berbasis web yang bernama e-Kinerja. Penilaian kinerja sangat berpengaruh terhadap efektivitas kerja pegawai pada Badan Kepegawaian Daerah Provinsi Sulawesi Utara. Hal ini untuk mengetahui hasil kinerja dari seorang pegawai apakah meningkat atau menurun. Rendahnya kualitas kinerja dari pegawai dapat disebabkan oleh beberapa aspek diantaranya adalah belum optimalnya tugas pokok dan fungsi dalam pekerjaan yang ada pada masing-masing bidang dan juga kurangnya ketepatan waktu dalam pelaksanaan e-kinerja, dengan indikator pengukuran efektivitas yaitu Ketepatan Waktu yang merupakan salah satu faktor penghambat dalam penerapan e-Kinerja.  Metode penelitian yang digunakan adalah metode penelitian deskriptif dengan pendekatan kualitatif dengan melakukan observasi, wawancara dan dokumetasi terhadap sumber data yang telah ditentukan. Hasil yang diperoleh menunjukkan bahwa penerapan e-Kinerja pada Badan Kepegawaian Daerah Provinsi Sulawesi Utara berpengaruh  positif dan signifikan terhadap prestasi kerja pegawai dan mampu meningkatkan kepuasan kerja yang didapatkan.
MARKETING DIGITAL CAMPAIGN DALAM MEMBANGUN STARTUP MELALUI INFLUENCER PADA MASA PANDEMI COVID-19
Authors: Purwatiningsih Sri Desti
Published: January 2022

Maraknya usaha rintisan startup yang banyak dibangun oleh kaum milenian disaat terjadinya pandemi Covid-19 yang melanda hampir di seluruh negara di dunia saat ini telah ikut membantu meningkatkan pertumbuhan ekonomi masyarakat.   Kampanye pemasaran digital melalui micro influencer juga telah meningkatkan pertumbuhan ekonomi digital. Peran micro celebrity sebagai influencer dalam usaha startup semakin meramaikan dunia pemasaran digital. Berbagai online shop maupun marketplace baru bermunculan, kaum milenial yang menguasai teknologi mulai menciptakan konten-konten kreatif serta perangkat yang mumpuni untuk mendukung persaingan di dunia e-commerce. Penelitian ini menggunakan Systematic Literature Review (SLR) atau kajian studi kepustakaan, yaitu metode penelitian untuk melakukan identifikasi, evaluasi dan interpretasi terhadap semua hasil penelitian yang relevan terkait pertanyaan penelitian tertentu, topik tertentu, atau fenomena yang menjadi perhatian penulis.
Mitochondrial Membrane Remodeling
Authors: Yang Ziyun , Wang Liang , Yang Cheng , Pu Shiming , Guo Ziqi , Wu Qiong , Zhou Zuping , Zhao Hongxia
Published: January 2022

Mitochondria are key regulators of many important cellular processes and their dysfunction has been implicated in a large number of human disorders. Importantly, mitochondrial function is tightly linked to their ultrastructure, which possesses an intricate membrane architecture defining specific submitochondrial compartments. In particular, the mitochondrial inner membrane is highly folded into membrane invaginations that are essential for oxidative phosphorylation. Furthermore, mitochondrial membranes are highly dynamic and undergo constant membrane remodeling during mitochondrial fusion and fission. It has remained enigmatic how these membrane curvatures are generated and maintained, and specific factors involved in these processes are largely unknown. This review focuses on the current understanding of the molecular mechanism of mitochondrial membrane architectural organization and factors critical for mitochondrial morphogenesis, as well as their functional link to human diseases.
Single-Cell RNA Sequencing Reveals the Role of Phosphorylation-Related Genes in Hepatocellular Carcinoma Stem Cells
Authors: Yao Fuwen , Zhan Yongqiang , Li Changzheng , Lu Ying , Chen Jiao , Deng Jing , Wu Zijing , Li Qi , Song Yi’an , Chen Binhua , Chen Jinjun , Tian Kuifeng , Pu Zuhui , Ni Yong , Mou Lisha
Published: January 2022

Abnormal activation of protein kinases and phosphatases is implicated in various tumorigenesis, including hepatocellular carcinoma (HCC). Advanced HCC patients are treated with systemic therapy, including tyrosine kinase inhibitors, which extend overall survival. Investigation of the underlying mechanism of protein kinase signaling will help to improve the efficacy of HCC therapy. Combining single-cell RNA sequencing data and TCGA RNA-seq data, we profiled the protein kinases, phosphatases, and other phosphorylation-related genes (PRGs) of HCC patients in this study. We found nine protein kinases and PRGs with high expression levels that were mainly detected in HCC cancer stem cells, including POLR2G, PPP2R1A, POLR2L, PRC1, ITBG1BP1, MARCKSL1, EZH2, DTYMK, and AURKA. Survival analysis with the TCGA dataset showed that these genes were associated with poor prognosis of HCC patients. Further correlation analysis showed that these genes were involved in cell cycle-related pathways that may contribute to the development of HCC. Among them, AURKA and EZH2 were identified as two hub genes by Ingenuity Pathway Analysis. Treatment with an AURKA inhibitor (alisertib) and an EZH2 inhibitor (gambogenic) inhibited HCC cell proliferation, migration, and invasion. We also found that both AURKA and EZH2 were highly expressed in TP53-mutant HCC samples. Our comprehensive analysis of PRGs contributes to illustrating the mechanisms underlying HCC progression and identifying potential therapeutic targets for future clinical trials.
Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
Authors: Rebulla Paolo , Querol Sergio , Pupella Simonetta , Prati Daniele , Delgadillo Joaquin , De Angelis Vincenzo
Published: January 2022

Most public cord blood banking programs are currently facing financial difficulties due to a progressive decline in the number of cord blood transplants performed worldwide and to a high discard rate of the donated units caused by progressively increasing thresholds of the stem cell dose required to perform safe and effective hemopoietic cord blood transplants. Recycling a proportion of unused cord blood units to prepare novel cord blood components obtained with minimal manipulation (platelets, plasma, red blood cells) and to develop more technologically complex products regulated in the US as Cellular and Gene Therapy Products and in Europe as Advanced Therapy Medicinal Products [e.g. virus-specific T cells (VST), natural killer (NK) cells, induced pluripotent stem cells (iPSCs) is a promising strategy to increase the therapeutic value and reduce the financial deficits of public cord blood banking. Based on encouraging preliminary evidences reported in the literature, additional laboratory studies, large multicenter clinical trials and international regulatory harmonization are necessary to achieve these important goals. This article describes organizational, methodological and regulatory advancements developed in Italy and Spain to promote the clinical use of cord blood platelets, plasma and red blood cells.
ZELDA: A 3D Image Segmentation and Parent-Child Relation Plugin for Microscopy Image Analysis in napari
Authors: D’Antuono Rocco , Pisignano Giuseppina
Published: January 2022

Bioimage analysis workflows allow the measurement of sample properties such as fluorescence intensity and polarization, cell number, and vesicles distribution, but often require the integration of multiple software tools. Furthermore, it is increasingly appreciated that to overcome the limitations of the 2D-view-based image analysis approaches and to correctly understand and interpret biological processes, a 3D segmentation of microscopy data sets becomes imperative. Despite the availability of numerous algorithms for the 2D and 3D segmentation, the latter still offers some challenges for the end-users, who often do not have either an extensive knowledge of the existing software or coding skills to link the output of multiple tools. While several commercial packages are available on the market, fewer are the open-source solutions able to execute a complete 3D analysis workflow. Here we present ZELDA, a new napari plugin that easily integrates the cutting-edge solutions offered by python ecosystem, such as scikit-image for image segmentation, matplotlib for data visualization, and napari multi-dimensional image viewer for 3D rendering. This plugin aims to provide interactive and zero-scripting customizable workflows for cell segmentation, vesicles counting, parent-child relation between objects, signal quantification, and results presentation; all included in the same open-source napari viewer, and “few clicks away”.
Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost
Authors: Human Paul , Bezuidenhout Deon , Aikawa Elena , Zilla Peter
Published: January 2022

Despite early realization of the need to control inherent immunogenicity of bioprosthetic replacement heart valves and thereby mitigate the ensuing host response and its associated pathology, including dystrophic calcification, the problem remains unresolved to this day. Concerns over mechanical stiffness associated with prerequisite high cross-link density to effect abrogation of this response, together with the insinuated role of leaching glutaraldehyde monomer in subsequent dystrophic mineralization, have understandably introduced compromises. These have become so entrenched as a benchmark standard that residual immunogenicity of the extracellular matrix has seemingly been relegated to a very subordinate role. Instead, focus has shifted toward the removal of cellular compartment antigens renowned for their implication in the failure of vascularized organ xenotransplants. While decellularization certainly offers advantages, this review aims to refocus attention on the unresolved matter of the host response to the extracellular matrix. Furthermore, by implicating remnant immune and inflammatory processes to bioprosthetic valve pathology, including pannus overgrowth and mineralization, the validity of a preeminent focus on decellularization, in the context of inefficient antigen and possible residual microbial remnant removal, is questioned.
Mitral Annular Forces and Their Potential Impact on Annuloplasty Ring Selection
Authors: Jedrzejczyk Johannes H. , Carlson Hanse Lisa , Javadian Shadi , Skov Søren N. , Hasenkam J. Michael , Thørnild Marcell J.
Published: January 2022

Objectives: To provide an overview that describes the characteristics of a mitral annuloplasty device when treating patients with a specific type of mitral regurgitation according to Carpentier's classification of mitral regurgitation.

Methods: Starting with the key search term “mitral valve annuloplasty,” a literature search was performed utilising PubMed, Google Scholar, and Web of Science to identify relevant studies. A systematic approach was used to assess all publications.

Results: Mitral annuloplasty rings are traditionally categorised by their mechanical compliance in rigid-, semi-rigid-, and flexible rings. There is a direct correlation between remodelling capabilities and rigidity. Thus, a rigid annuloplasty ring will have the highest remodelling capability, while a flexible ring will have the lowest. Rigid- and semi-rigid rings can furthermore be divided into flat and saddled-shaped rings. Saddle-shaped rings are generally preferred over flat rings since they decrease annular and leaflet stress accumulation and provide superior leaflet coaptation. Finally, mitral annuloplasty rings can either be complete or partial.

Conclusions: A downsized rigid- or semi-rigid ring is advantageous when higher remodelling capabilities are required to correct dilation of the mitral annulus, as seen in type I, type IIIa, and type IIIb mitral regurgitation. In type II mitral regurgitation, a normosized flexible ring might be sufficient and allow for a more physiological repair since there is no annular dilatation, which diminishes the need for remodelling capabilities. However, mitral annuloplasty ring selection should always be based on the specific morphology in each patient.
Impact of Solar Activity on Snow Cover Variation Over the Tibetan Plateau and Linkage to the Summer Precipitation in China
Authors: Song Yan , Li Zhicai , Gu Yu , Xiao Ziniu
Published: January 2022

Solar activity is one of the main external forcing factors driving the Earth’s climate system to change. The snow cover over the Tibetan Plateau is an important physical factor affecting the East Asian climate. At present, insufficient research on the connection between solar activity and snow cover over the Tibetan Plateau has been carried out. Using Solar Radio Flux (SRF), Solar Sunspot Number (SSN), and Total Solar Irradiance (TSI) data, this paper calculated the correlation coefficients with snow indices over the Tibetan Plateau, such as winter and spring snow depth (WSD/SSD) and snow day number (WSDN/SSDN). These snow indices are obtained from the daily gauge snow data in the Tibetan Plateau. Through correlation analyses, it is found that there are significant synchronous or lag correlations between snow indices and solar parameters on multi-time scales. In particular, the Spring Snow Day Number (SSDN) is of significant synchronous or lag correlation with SRF, SSN, and TSI on multi-time scales. It is further found that SSDN over the Tibetan Plateau has more stable positive correlations with SRF by using the 21-year running mean and cross spectrum analyses. Therefore, SSDN can be ascertained to be the most sensitive snow index to the solar activity compared with other snow indices. Moreover, its influence on summer precipitation of China is strongly regulated by solar activity. In high solar activity years (HSAY), the significant correlated area of summer precipitation in China to SSDN is located further north than that in low solar activity years (LSAY). Such impact by solar activity is also remarkable after excluding the impact of ENSO (i.e., El Niño–Southern Oscillation) events. These results provide support for the application of snow indices in summer rainfall prediction in China.
Subclinical Hypothyroidism as the Most Common Thyroid Dysfunction Status in Children With Down’s Syndrome
Authors: Szeliga Kamila , Antosz Aleksandra , Skrzynska Karolina , Kalina-Faska Barbara , Januszek-Trzciakowska Aleksandra , Gawlik Aneta
Published: January 2022

Introduction

Thyroid dysfunctions are one of the most common abnormalities coexisting in children with Down’s syndrome (DS) and have been reported in up to 54% of cases.

Aim of the Study

The purposes of this retrospective study were to investigate the course of subclinical hypothyroidism in children with DS, to evaluate the thyroid function of these subjects in relation to the risk of developing overt thyroid disease and autoimmunity, and to identify clinical and biochemical characteristics of patients prescribed L-T4 therapy in children and adolescents with DS and SH.

Material and Methods

The records of DS patients referred to the Endocrinology Outpatient Clinic between 2010 and 2015 for screening of thyroid function were observed till the end of 2019 June and analyzed retrospectively. The children diagnosed with congenital hypothyroidism, acute lymphoblastic leukemia, and seizures and treated with drugs that may have interfered with thyroid function like lithium, antiepileptic, or iodinated drugs and glucocorticoids were excluded from the study.

Results

The data of 77 DS patients were collected, evaluated, and analyzed. The study group consisted of 73 patients (32 girls and 41 boys with the mean age at baseline of 3.0 ± 4.5 years). A total of 63/73 (87%) children were diagnosed with SH. The 16/63 (25.4%) patients were followed-up without the treatment (group SH-T0), and therapy with levothyroxine (L-T4) was introduced in 47/63 (74.6%) SH children with a mean dosage of 1.8 ± 1.0 μg/kg/day (group SH-T1). Thyroxine supplementation did not improve growth expressed as ΔhSDS (0.1 ± 1.3, ranged −2.1 to 3.8 in SH-T0 vs. 0.0 ± 0.7, ranged −1.7 to 1.4 in SH-T1, p = 0.96) and ΔBMI Z-score (0.3 ± 0.9, ranged −0.9 to 2.6 in SH-T0 vs. 0.3 ± 1.1, ranged −2.1 to 2.9 in SH-T1, p = 0.65). Positive anti-TPO and anti-TG antibodies were detected in 7/63 (11.1%) DS cases.

Conclusions

SH is the most frequent presentation of thyroid gland dysfunction in DS children. A small percentage of patients develop an overt hypothyroidism, particularly in females with mostly positive titer of antithyroid autoantibodies.
Challenges in the Management of Atrial Fibrillation With Subclinical Hyperthyroidism
Authors: Gencer Baris , Cappola Anne R. , Rodondi Nicolas , Collet Tinh-Hai
Published: January 2022

Subclinical thyroid disorders have a high prevalence among older individuals and women. Subclinical hypothyroidism is diagnosed by elevated serum levels of thyroid-stimulating hormone (TSH) with thyroxine levels within the reference range, and subclinical hyperthyroidism is diagnosed by low TSH in conjunction with thyroxine and triiodothyronine levels within reference ranges. Atrial fibrillation is the most commonly diagnosed cardiac arrhythmia and has been associated with an increased risk of mortality, heart failure, stroke, and depression. Mechanistic data from animal and human physiology studies as well as observational data in humans support an association of subclinical hyperthyroidism with atrial fibrillation. Guidelines recommend the measurement of TSH in the evaluation of new-onset atrial fibrillation. All patients with overt hyperthyroidism should be treated, and treatment of subclinical hyperthyroidism should be considered in patients older than 65 years with TSH < 0.4 mlU/L, or in younger patients with TSH < 0.1 mlU/L. Guidelines also recommend screening for AF in patients with known hyperthyroidism. Wearable devices that measure the heart electrical activity continuously may be a novel strategy to detect atrial fibrillation in patients at risk. In this review, we explore the interplay between thyroid hormones and atrial fibrillation, management controversies in subclinical hyperthyroidism, and potential strategies to improve the management of atrial fibrillation in patients with subclinical hyperthyroidism.