bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of course timetabling on learning quality: sustaining an optimized stress level to stimulate enhanced comprehension
Authors: Razavi Seyed Reza , Akgunduz Ali , Zeng Yong
Published: October 2022

This paper aims to improve students’ learning performance by optimizing their mental stresses in learning through proposing a new course timetabling method. This new method is based on two hypotheses that formulate the link between course timetabling and learning experience: i) a student’s learning performance is superior when the student is subject to moderate stress; ii) an individual’s mental capacity varies during a day according to Circadian Rhythm. The student’s mental stress in taking a course is defined as a function of their mental capacity and the workload required by the course. The workload is determined by utilizing a multi-criteria prioritization technique—Analytic Hierarchy Process. As a result, the timetabling problem is formulated as a mixed-integer linear programming model, which is tested on an engineering program to produce a student-centered timetable for its scheduled courses. This new method differs from traditional course scheduling and timetabling approaches, which are usually tackled as a constrained optimization problem with an objective to optimize a given set of criteria, such as student and faculty preferences, walking distances between consecutive classes, classroom utilization and operating expenses.
Boxing with and without Kicking Techniques for People with Parkinson’s Disease: An Explorative Pilot Randomized Controlled Trial
Authors: Domingos Josefa , de Lima Ana Ligia Silva , Steenbakkers-van der Pol Tessa , Godinho Catarina , Bloem Bastiaan R. , de Vries Nienke M.
Published: October 2022

Background: People with Parkinson’s disease (PD) benefit from boxing exercise. Adding kicking variations to the boxing may provide additional benefit to improve balance. However, the benefits and adherence to such trainings is unknown. Objective: To explore the feasibility, safety, and benefits on balance of boxing training combined with kicking techniques in comparison to boxing without kicking in PD. Methods: Participants were randomized to group-based boxing training with kicking techniques (BK) or to group-based boxing alone training (BO). Both groups trained for one hour, once a week, for a period of 10 weeks. Participants were assessed at baseline and ten weeks post-intervention for difference in balance, fear of falling, balance confidence, walking ability, and quality of life. Results: Twenty-nine people with PD (median age 64 years; median disease duration 5 years) participated. Both interventions were feasible and acceptable for all participants. No adverse events occurred. Most participants (BK 80%; BO 75%) were satisfied with the training. We found no significant between group difference on either the primary (Mini-BEST) or secondary outcomes. The within group comparison showed that balance improved in both groups after the intervention (BK 22.60 (2.7) to 25.33 (2.64) p = 0.02; BO 23.09 (3.44) to 25.80 (2.39); p = 0.01 on the Mini BEST test). Conclusion: Both types of boxing seem to be feasible and safe. Adding kicking techniques to boxing does not improve balance significantly more than boxing alone. Incorporation of kicking may be a valuable addition to the exercise therapy repertoire.
Body-First Subtype of Parkinson’s Disease with Probable REM-Sleep Behavior Disorder Is Associated with Non-Motor Dominant Phenotype
Authors: Pavelka Lukas ,   on behalf of the NCER-PD Consortium, Rauschenberger Armin , Landoulsi Zied , Pachchek Sinthuja , Marques Taina , Gomes Clarissa P.C. , Glaab Enrico , May Patrick , Krüger Rejko
Published: October 2022

Background: The hypothesis of body-first vs. brain-first subtype of PD has been proposed with REM-Sleep behavior disorder (RBD) defining the former. The body-first PD presumes an involvement of the brainstem in the pathogenic process with higher burden of autonomic dysfunction. Objective: To identify distinctive clinical subtypes of idiopathic Parkinson’s disease (iPD) in line with the formerly proposed concept of body-first vs. brain-first subtypes in PD, we analyzed the presence of probable RBD (pRBD), sex, and the APOE ɛ4 carrier status as potential sub-group stratifiers. Methods: A total of 400 iPD patients were included in the cross-sectional analysis from the baseline dataset with a completed RBD Screening Questionnaire (RBDSQ) for classifying as pRBD by using the cut-off RBDSQ≥6. Multiple regression models were applied to explore (i) the effect of pRBD on clinical outcomes adjusted for disease duration and age, (ii) the effect of sex on pRBD, and (iii) the association of APOE ɛ4 and pRBD. Results: iPD-pRBD was significantly associated with autonomic dysfunction (SCOPA-AUT), level of depressive symptoms (BDI-I), MDS-UPDRS I, hallucinations, and constipation, whereas significantly negatively associated with quality of life (PDQ-39) and sleep (PDSS). No significant association between sex and pRBD or APOE ɛ4 and pRBD in iPD was found nor did we determine a significant effect of APOE ɛ4 on the PD phenotype. Conclusion: We identified an RBD-specific PD endophenotype, characterized by predominant autonomic dysfunction, hallucinations, and depression, corroborating the concept of a distinctive body-first subtype of PD. We did not observe a significant association between APOE ɛ4 and pRBD suggesting both factors having an independent effect on cognitive decline in iPD.
Disability acceptance as a moderator of the impacts of disability stigma on job satisfaction of people with disabilities in the workplace
Authors: Kim Jaeyoung
Published: October 2022

BACKGROUND: Disability stigma is a significant risk factor that reduces job satisfaction. Based on the previous studies, the role of disability acceptance as a buffer to prevent the negative impact of stigma in the workplace is hypothesized. OBJECTIVE: This study examined the moderating effect of disability acceptance on the negative effects of disability stigma on job satisfaction of people with disabilities. METHODS: 164 participants working at the time of the survey completed questionnaires measuring disability stigma, disability acceptance, and job satisfaction. The associations among the three variables were examined using simple linear regression analyses. Hierarchical linear regression analysis was conducted to identify the moderating effect of disability acceptance after controlling disability type. RESULTS: Disability stigma (β=–0.17, p < 0.05) and disability acceptance (β=0.18, p < 0.05) were significantly associated with job satisfaction respectively. In the final model, disability acceptance moderated the relationship between disability stigma and job satisfaction (β=–0.16, p < 0.05). Specifically, the impacts of disability stigma on job satisfaction for participants with higher disability acceptance differed from those with lower acceptance. CONCLUSION: The current research suggests that disability acceptance plays a critical role for people with disabilities to cope with the negative impact of disability stigma. This result implies that disability acceptance should be an important focus of intervention to increase job satisfaction.
Results from phase one of an early intervention vocational rehabilitation trial for people with spinal cord injury conducted in Queensland, Australia
Authors: Bloom Julia , McLennan Vanette , Dorsett Pat
Published: October 2022

BACKGROUND: The Back2Work Early Intervention Vocational Rehabilitation (EIVR) program was developed in response to the low employment rate of people with spinal cord injuries (SCI) and their lack of access to early, specialised vocational rehabilitation (VR). The program has been delivered by qualified rehabilitation counsellors to hospital patients with newly acquired SCI since 2016. OBJECTIVE: The objective of the study was to evaluate the effectiveness and consumer perspective of the Back2Work EIVR program. METHODS: The program was evaluated using a mixed-methods, longitudinal, prospective design. RESULTS: Data analysis revealed a return to work rate (RTW) of 43% by 12 months post-discharge. Qualitative data indicated positive participant experiences with the program, emphasising the hopefulness brought about by early vocational support. CONCLUSIONS: The Back2Work program has a positive impact on participants’ RTW outcomes, through the provision of early specialist vocational rehabilitation interventions. This includes building a positive culture around RTW after SCI and engagement with employers to maximise the likelihood of timely and sustainable re-employment. The RTW outcomes and emergent themes will help inform service development in the field of early vocational rehabilitation after SCI.
ANALISIS PENGARUH KUALITAS PELAYANAN, KEBERAGAMAN PRODUK, HARGA DAN LOKASI TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN DI ALFAMIDI TRITUNGGAL YOGYAKARTA
Authors: Ghufron Muhamad , Zuraida Lukia
Published: October 2022

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh kualitas pelayanan terhadap keputusan pembelian pada pelanggan Alfamidi Tritunggal Yogyakarta, (2) pengaruh keberagaman produk terhadap keputusan pembelian pada pelanggan Alfamidi Tritunggal Yogyakarta, (3) pengaruh harga terhadap keputusan pembelian pada pelanggan Alfamidi Tritunggal Yogyakarta, dan (4) pengaruh lokasi terhadap keputusan pembelian pada pelanggan Alfamidi Tritunggal Yogyakarta (5) pengaruh kualitas pelayanan, keberagaman produk, harga, dan lokasi terhadap keputusan pembelian pada pelanggan Alfamidi Tritunggal Yogyakarta. Penelitian ini menggunakan metode asosiatif kausal dengan menggunakan pendekatan kuantitatif. Populasi dalam penelitian ini adalah konsumen yang pernah melakukan pembelian di Alfamidi Tritunggal Yogyakarta. Teknik pengambilan sampel menggunakan accidental sampling dengan jumlah sampel sebanyak 100 orang. Teknik pengumpulan data menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Teknik analisis data menggunakan regresi berganda. Hasil penelitian menunjukkan bahwa: (1) kualitas pelayanan berpengaruh positif terhadap keputusan pembelian pada pelanggan Alfamidi (t hitung =1.675; nilai signifikansi 0,097<0,05; dan koefisien regresi = 0,159); (2) keberagaman produk berpengaruh positif terhadap keputusan pembelian pada pelanggan Alfamidi (t hitung = 4.720; nilai signifikansi 0,000<0,05; dan koefisien regresi = 0,395); (3) harga berpengaruh positif terhadap keputusan pembelian pada pelanggan Alfamidi (t hitung = 4.206; nilai signifikansi 0,000<0,05; dan koefisien regresi = 0,366); (4) lokasi tidak berpengaruh terhadap keputusan pembelian pada pelanggan Alfamidi (t hitung = 0,472; nilai signifikansi 0,638>0,05; dan koefisien regresi = 0,038); dan (5) kualitas pelayanan, keberagaman produk, harga, dan lokasi berpengaruh secara bersama-sama terhadap keputusan pembelian pada pelanggan Alfamidi Tritunggal Yogyakarta (F hitung= 47,673 dengan signifikansi 0,000<0,05).
PENGARUH MOTIVASI KERJA, DISIPLIN KERJA DAN KOMPENSASI TERHADAP PRODUKTIVITAS KERJA KARYAWAN DI RUMAH MAKAN SATE KLATAK PAK PONG
Authors: Asteria Beta , Dwiyanto Andri
Published: October 2022

This research aims to analyze (1) the effect of work motivation on the work productivity of employees at Sate Klathak Pak Pong Restaurant, (2) the effect of work discipline on employee productivity of employees at Sate Klathak Pak Pong Restaurant, (3) the effect of compensation for productivity Employee work at the Sate Klathak Pong Pong Restaurant, the effect of motivation, work discipline, and compensation for the work productivity of employees at Sate Klathak Pak Pong Restaurant. This research uses the Causal Associative method using a quantitative approach. The population in the study was an employee at Sate Klathak Pak Pong Restaurant. Sampling techniques use random Sampling with a total sample of 100 people. Data collection techniques using a questionnaire that has been tested for validity and reliability. Data analysis techniques use multiple regression. The results showed that: (1) work motivation has a negative effect on the work productivity of employees at Sate Klathak Pak Pong Restaurant (t count = -2.144; significance value of 0.35< 0.05; and regression coefficient = - 0.318); 2) Work discipline does not affect the work productivity of employees at Sate Klathak Pak Pong Restaurant (t count = 0.588; significance value of 0.558>0.05; and Regression coefficient = 0.94); Compensation has a positive effect on productivity employee work at Sate Klathak Pak Pong Restaurant (T count = 7,437; significance value of 0,000<0.05; regression coefficient = 0.768).
PENGARUH TANGIBILITY, PROFITABILITAS, DAN LIKUIDITAS TERHADAP STRUKTUR MODAL PADA PERUSAHAAN MANUFAKTUR SUB SEKTOR FOOD AND BEVERAGE YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2017-2020
Authors: Ambarwati Lilik , Risanti Iin , Yulianto Prafid Dwi
Published: October 2022

Penelitian ini bertujuan untuk menguji pengaruh tangibility, profitabilitas dan likuiditas terhadap struktur modal pada perusahaan manufaktur sub sektor food and beverage yang terdaftar di Bursa Efek Indonesia periode 2017-2020. Tangibility diukur dengan fixed asset ratio, profitabilitas diukur dengan return on equity dan likuiditas diukur dengan current ratio. Penelitian ini merupakan penelitian kuantitatif. Sampel dalam penelitian ini diperoleh dengan metode purposive sampling, yaitu pemilihan sampel dengan kriteria-kriteria yang telah ditentukan. Berdasarkan metode purposive sampling dengan kriteria yang telah ditentukan didapatkan sebanyak 80 sampel dari 20 perusahaan manufaktur sub sektor food and beverage yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2017-2020. Metode yang digunakan dalam penelitian ini adalah teknik analisis regresi berganda yang diolah menggunakan program SPSS versi 25. Hasil penelitian berdasarkan uji F, menunjukkan bahwa tangibility berpengaruh positif signifikan, likuiditas berpengaruh negatif signifikan terhadap struktur modal dengan nilai signifikansi < 0,05 sedangkan profitabilitas tidak berpengaruh terhadap struktur modal. Dilihat dari uji F, variabel independen secara simultan berpengaruh terhadap struktur modal, dengan nilai F 15,768 dan signifikansi 0,000 ketiga variabel independen tersebut mempengaruhi struktur modal sebesar 60,7% sisanya dijelaskan oleh sebab-sebab atau variabel lain.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEPATUHAN WAJIB PAJAK DALAM MEMBAYAR PAJAK PENGHASILAN
Authors: Kundala Manendha Maganitri , Karmilah Karmilah , Ahmadi Pandit Fatih
Published: October 2022

Penelitian ini bertujuan untuk menganalisis pengaruh kesadaran membayar pajak, pengetahuan dan pemahaman peraturan perpajakan, sanksi perpajakan dan motivasi terhadap kepatuhan wajib pajak. Metode pengambilan sampel menggunakan kuesioner sehingga diperoleh 42 responden yang berdomisili di Bantul Yogyakarta. Metode analisis yang digunakan dalam penelitian ini adalah metode analisis regresi berganda. Hasil penelitian menunjukkan bahwa variabel sanksi perpajakan berpengaruh positif signifikan terhadap kepatuhan wajib pajak. Sedangkan variabel kesadaran membayar pajak, pengetahuan dan pemahaman peraturan perpajakan dan motivasi tidak berpengaruh signifikan terhadap kepatuhan pajak.
STRATEGI PENINGKATAN KUALITAS PRODUK PERUSAHAAN BATIK
Authors: Suhartono Suhartono , Prasetiyo Fajar
Published: October 2022

Batik Nilo is a company engaged in the batik industry. The purpose of this research is to formulate the right strategy to be applied to the company. Data collection techniques used are observation, documentation, and interviews. Data analysis technique using IE matrix and SWOT matrix. The strategy obtained to determine the strategy to improve product quality, the results in Quadrant 1 are to support the aggressive Growth Oriented Strategy with the following strength and opportunity points: continue to increase the variety of motifs, maintain and improve the quality of natural coloring, and use quality raw materials.
PENGARUH UKURAN PERUSAHAAN DAN KEPEMILIKAN INSTITUSIONAL TERHADAP TAX AVOIDANCE DENGAN PROFITABILITAS SEBAGAI VARIABEL INTERVENING
Authors: Tjahjono Achmad , Setyawan Yohanes Ambar , Prasetyo Agung Slamet
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh ukuran perusahaan dan kepemilikan institusional terhadap tax avoidance dengan profitabilitas sebagai variabel intervening. Populasi penelitian ini adalah seluruh perusahaan manufaktur sektor industri dasar dan kimia di BEI Periode 2016-2020. Metode sampling menggunakan metode nonprobability sampling dengan teknik purposive sampling. Teknik analisis data menggunakan uji asumsi klasik yaitu uji multikolinieritas, uji autokorelasi, uji heteroskedastisitas dan uji normalitas. Pengujian hipotesis menggunakan analisis jalur (path analysis). Hasil penelitian menyimpulkan bahwa: (1) Ukuran perusahaan memiliki pengaruh positif dan signifikan terhadap Profitabilitas, (2) Kepemilikan institusional memiliki pengaruh positif dan signifikan terhadap Profitabilitas, (3) Profitabilitas berpengaruh positif dan signifikan terhadap tax avoidance yang diukur dengan effective tax rate, (4) Ukuran perusahaan berpengaruh positif dan signifikan terhadap tax avoidance yang diukur dengan effective tax rate, (5) Kepemilikan institusional berpengaruh positif dan signifikan terhadap tax avoidance yang diukur dengan effective tax rate, (6) Profitabilitas tidak mampu memberikan pengaruh yang signifikan antara ukuran perusahaan dan tax avoidance, (7) Profitabilitas tidak mampu memberikan pengaruh yang signifikan antara kepemilikan institusional dan tax avoidance.
Desarrollo de la canción huichola. Etapa 3: de los 10 a los 15 años
Authors:   Universidad de Guadalajara
Published: October 2022

Mi investigación de las canciones persigue como objetivo general analizar el desarrollo de la capacidad de las personas para componerlas y comprenderlas (Ramírez, 1993, 2005, 2007, 2013). Para clasificar los textos siguiendo las edades de la vida, tal como las concebimos los huicholes, se requieren criterios relacionados tanto con el crecimiento físico como con el cognitivo, con la asimilación del conocimiento de la cultura huichola —a través de sus múltiples fiestas e innumerables ceremonias civiles y religiosas—, así como con los textos que las acompañan. En estos últimos se trasmiten los hechos de la memoria colectiva, histórica y cultural, y se dictan las normas éticas y estéticas ancestrales. A través de estas edades, las canciones reflejan las enseñanzas de nuestros antepasados en la conformación de la relación espiritual entre el ser humano y la naturaleza.
ANALISIS KONDISI KERUSAKAN JALAN MENGGUNAKAN METODE PAVEMENT CONDITION INDEX (PCI) DAN INTERNATIONAL ROUGHNESS INDEX (IRI) BESERTA ALTERNATIF PENANGANANNYA (Studi Kasus: Jalan Samaun Pulubuhu - Jalan Boliohuto Huidu - Jalan A.K. Luneto)
Authors: Koromath Herris Julian , Desei Frice L , Kadir Yuliyanti
Published: October 2022

Samaun Pulubuhu Street - Boliohuto Huidu Street - A.K. Luneto Street is one of the roads connecting Gorontalo City, Djalaludin Airport, and surrounding districts in Gorontalo Province. This study aims to compare the value of road conditions based on the PCI and IRI methods and determine the alternative treatments.This study uses the Pavement Condition Index (PCI) and International Roughness. Index (IRI) methods. The PCI value is obtained through a direct visual survey of road conditions. The IRI value was obtained through a survey using a car and the Roadlab Pro application.The results show that the condition of the roads based on the PCI method is excellent  19.44%, very good 8.8%, good 14.81%, moderate 18.06%, bad 17.13%, very bad 10.65%, and failed 11.11%. Meanwhile, road conditions based on the IRI method are good 3.13%, moderate  64.06%, lightly damaged 21.09%, and heavily damaged 11.72%. The PCI value on Samaun Pulubuhu Street is 52.48 in moderate condition with the type of treatment needed is minor rehabilitation, on Boliohuto Huidu Street is 61,53 in good condition with the type of treatment needed is routine maintenance, and on A.K. Luneto Street is 23.98 in bad condition with the type of treatment needed is reconstruction. The IRI value on Samaun Pulubuhu Street is 8.42 in a slightly damaged condition with the type of treatment needed is road quality improvement, on Boliohuto Huidu Street - A.K. Luneto Street are 5.68 and 6.41 in moderate condition with the type of treatment needed is regular maintenance.
PENGARUH PENAMBAHAN SEMEN, ABU SEKAM, DAN SERAT FIBER TERHADAP PENINGKATAN KUAT GESER TANAH LEMPUNG
Authors: . Indrayani Indrayani , Herius Andi , Ashadiq Alfin , Hardewo Egal , Hasan Arpan , Praditya Norca , Prabudi Darma
Published: October 2022

Tanah merupakan suatu unsur penting dalam mendukung kegiatan pembangunan di dunia konstriksi sipil. Salah satu jenis tanah yang sering di temukan di Sumatra Selatan ini ialah tanah lempung. Tanah lempung merupakan jenis tanah berbutir halus yang sangat di pengaruhi oleh kadar air. Setiap tanah lempung mempunyai nilai daya dukung yang berbeda beda, Oleh karna itu di perlukan analisa untuk menguji pengaruh penambahan bahan campuran terhadap tanah lempung. Untuk melihat pengaruh penambahan bahan campuran terhadap tanah dilakukan sebuah pengujian, dalam pengujian ini di ambil sampel tanah dari daerah kabupaten banyuasin serta ditambah bahan campuran berupa serat fiber, abu sekam dan semen. Untuk variasi pengujian campuran tanah, serat fiber 0,1%, abu sekam 2,5% dan semen terdiri dari 2,5%, 5% dan 7,5% serta air biasa. Hasil pengujian menunjukkan dengan penambahan bahan campuran serat fiber, abu sekam dan semen dapat memperbaiki sifat fisis dan mekanis tanah lempung, dimana nilai kohesi meningkat pada penambahan semen 7,5% sebesar 43,78 dengan sudut geser sebesar 17,30o.
PEMANFAATAN BATU GUNUNG BOU BUYA KABUPATEN POSO UNTUK CAMPURAN AC-WC
Authors: Bunga Efraim , Alpius Alpius , Radjawane Louise Elizabeth
Published: October 2022

Road infrastructure development is one of the government's efforts to improve the welfare of the Indonesian people, both in urban areas and in remote areas. The use of local materials for road pavement is recommended that its use can be maximized and can reduce dependence on materials originating from outside the region. Poso Regency is one area that has the potential to have a source of material in the form of mountain rock aggregates. The purpose of the study was to determine the characteristics of the AC-WC mixture using aggregate from Mount Bou Buya, Poso Regency, and to determine the Marshall Immersion value of the AC-WC mixture using rock aggregate from Mount Bou Buya. The 2018 Bina Marga General Specifications are used as a reference in this study. the composition of the mixture for asphalt content of 5% coarse aggregate is 37.50%, fine aggregate is 51.50%, filler is 6%, for asphalt content is 5.5% coarse aggregate is 37.35%, fine aggregate is 51.20%, filler 5 ,95%, for asphalt content of 6%, coarse aggregate is 37.20%, fine aggregate is 50.90%, filler is 5.90%, for asphalt content is 6.5%, coarse aggregate is 37.05%, fine aggregate is 50.60 %, 5.85% filler, for asphalt content of 7%, coarse aggregate is 36.90%, fine aggregate is 50.30%, filler is 5.80%. Marshall Immersion Test (residual Marshall Stability) for the AC – WC mixture using Batu Gunung Bou Buya aggregate, Poso Regency following the General Specifications of Highways 2018, which is 98.04%.
Economic content of the enterprises efficiency
Authors: Nazarenko I.
Published: October 2022

Improvement of activity efficiency is one of the main factors in the companies development in the current crisis, which is caused by Russian aggression and the consequences of the pandemic. The results of the analysis of the essence of «enterprise efficiency» concept indicate the presence of significant number of opinions of scientists on the content of this concept in the absence of a single common definition. The initial number of opinions of scientists regarding the content of «efficiency» concept is analyzed. This concept always remains close in its meaning to the concept of effectiveness and indicates the results of activity, the basis for evaluating the company's activity, its competitiveness and characterizes the peculiarities of work. This economic category expresses the relationship between the final result of production – the effect and the total costs of production. The paper summarizes the opinion of a number of scientists in approaches to determining efficiency, which express an understanding of efficiency as an economic category, which is the effectiveness of the functioning of the system and is calculated as the ratio of the obtained result (effect) to the expenditure of funds and resources. It is also established that efficiency comes from the word effect, which characterizes the change in the state of any object or system under the influence of internal or external cause. The main scientific approaches to the interpretation of the essence of economic efficiency are systematized and it is established that most authors, in their formulations of economic efficiency, understand this category as the ratio of the effect to the costs or resources that are spent to obtain it, that is, the efficiency criteria are formed on the basis of cost and resource approaches. The effect of production is investigated, the general expression of which is the economic effect, which directly reflects changes in labor and means of production, and indirectly – socio-economic changes. The definition of «efficiency of the enterprise's activity» concept is clarified due to the consideration of the main properties of the studied definition, the dependence of the enterprise's activity efficiency on all resources and reserves. The main indicator of the efficiency of the enterprise's activity is its profit.
Pemberdayaan Masyarakat Terhadap Limbah Rumah Tangga Organik Dengan Teknik Komposter
Authors: Ratu Eva Ferbriani  , Retno Agustina Ekaputri  , Mochammad Ridwan
Published: October 2022

Household waste is the most common type of waste produced as a side effect of human activities. In its development, the handling of this waste problem cannot only rely on the government but there needs to be another alternative in the form of community empowerment in managing household waste through the application of composter techniques. By using a composter, besides reducing waste generation, it also helps maintain the capacity of the landfill and can create new sources of income for households. This service activity aims to educate the public about waste and its processing. The locus of this activity is RT 05 Bentiring Village, Bengkulu City, using the extension method. This community service activity has succeeded in changing the community's paradigm in managing household waste and encouraging the application of composting techniques at home.
EID3 Promotes Glioma Cell Proliferation and Survival by Inactivating AMPKα1
Authors: Xiang Yaoxian , Zhu Lei , He Zijian , Xu Lei , Mao Yuhang , Jiang Junjian , Xu Jianguang
Published: October 2022

Objective : EID3 (EP300-interacting inhibitor of differentiation) was identified as a novel member of EID family and plays a pivotal role in colorectal cancer development. However, its role in glioma remained elusive. In current study, we identified EID3 as a novel oncogenic molecule in human glioma and is critical for glioma cell survival, proliferation and invasion.Methods : A total of five patients with glioma were recruited in present study and fresh glioma samples were removed from patients. Four weeks old male non-obese diabetic severe combined immune deficiency (NOD/SCID) mice were used as transplant recipient models. The subcutaneous tumor size was calculated and recorded every week with vernier caliper. EID3 and AMP-activated protein kinase α1 (AMPKα1) expression levels were confirmed by real-time polymerase chain reaction and Western blot assays. Colony formation assays were performed to evaluate cell proliferation. Methyl thiazolyl tetrazolium (MTT) assays were performed for cell viability assessment. Trypan blue staining approach was applied for cell death assessment. Cell Apoptosis DNA ELISA Detection Kit was used for apoptosis assessment.Results : EID3 was preferentially expressed in glioma tissues/cells, while undetectable in astrocytes, neuronal cells, or normal brain tissues. EID3 knocking down significantly hindered glioma cell proliferation and invasion, as well as induced reduction of cell viability, apoptosis and cell death. EID3 knocking down also greatly inhibited tumor growth in SCID mice. Knocking down of AMPKα1 could effectively rescue glioma cells from apoptosis and cell death caused by EID3 absence, indicating that AMPKα1 acted as a key downstream regulator of EID3 and mediated suppression effects caused by EID3 knocking down inhibition. These findings were confirmed in glioma cells generated patient-derived xenograft models. AMPKα1 protein levels were affected by MG132 treatment in glioma, which suggested EID3 might down regulate AMPKα1 through protein degradation.Conclusion : Collectively, our study demonstrated that EID3 promoted glioma cell proliferation and survival by inhibiting AMPKα1 expression. Targeting EID3 might represent a promising strategy for treating glioma.
Clinical Manifestations of Thyroid-associated Ophthalmopathy Accompanied by Thyroid Cancer
Authors: Lee Seung Hyeun , Lee Jeong Kyu
Published: October 2022

Purpose: To analyze the clinical manifestations of thyroid-associated ophthalmopathy accompanied by thyroid cancer.Methods: We performed a retrospective chart review of 33 patients diagnosed at our ophthalmology department with both thyroid- associated ophthalmopathy and thyroid cancer. We performed thyroid function tests at the first visit and at diagnosis of the thyroid cancer, and recorded the type of thyroid cancer, thyroidectomy history, clinical activity score (CAS), exophthalmometry, margin reflex distance (MRD) 1, diplopia, follow-up duration of ophthalmopathy, and ocular treatments. We divided patients into two groups according to the time of diagnosis of thyroid ophthalmopathy and thyroid cancer.Results: The average age of the 33 patients was 45.55 years, and eight and 25 were males and females, respectively. The average CAS score, exophthalmometry measurement, and MRD1 were 2.00 ± 1.67, 19.28 ± 3.24 mm, and 4.52 ± 1.58 mm, respectively. Patients whose ocular symptoms preceded the diagnosis of thyroid cancer tended to have a higher thyroid hormone level, CAS score, and exophthalmometry measurement, and required more ocular treatments, compared to the other patients. The average thyroid auto-antibody levels were increased in both groups. In patients whose ophthalmopathy preceded the thyroid cancer, exophthalmometry measurements were significantly decreased after thyroidectomy.Conclusions: It is crucial to identify ophthalmopathy in association with thyroid cancer. Patients whose ocular symptoms started before the diagnosis of thyroid cancer may present with hyperthyroidism and severe ocular symptoms, and may need ocular treatments. Patients should be informed that thyroid-associated ophthalmopathy may develop after thyroidectomy or radioiodine therapy, and their ocular symptoms should be closely monitored.
Changes in Corneal Higher-order Aberrations and Astigmatism after Upper Eyelid Surgery
Authors: Han Dong Jin , Lee Do Hyung , Seo Ji Won , Yum Jung Hoon , Lee Jong Hyun
Published: October 2022

Purpose: We investigated the effects of upper eyelid surgery on corneal higher-order aberrations and astigmatism.Methods: We enrolled 38 patients (66 eyes) who underwent blepharoplasty and 48 (81 eyes) who underwent levator resection. The marginal reflex distance1 (MRD1), corneal astigmatism, and corneal higher-order aberrations were measured preoperatively, and at 6 months postoperatively, and the two groups were compared.Results: Corneal astigmatism decreased significantly in the ptosis repair group (p < 0.001) but there was no significant change in the axis of astigmatism. Preoperative third-order and coma-like aberrations were significantly more common in the ptosis repair group than in the other group (p = 0.027 and p = 0.044, respectively); both decreased significantly after the operation (p = 0.030 and p = 0.006, respectively). The decrease in MRD1 and changes in the two aberrations showed a significantly stronger negative correlation in the ptosis repair group than in the other group (b = -0.186; p < 0.001 and b = -0.159; p < 0.001, respectively).Conclusions: For patients with both cataract and ptosis, it is best to perform levator resection surgery before cataract surgery, because corneal higher-order aberrations and astigmatism are improved by levator resection. In turn, this reduces postoperative refractive error and improve vision quality.
Strengthening of Biomolecular Engineering Competence for Pharmacists in Batu City through Webinars and Workshops on Isolation of Genetic Material, Real-Time PCR, and its Applications in the Clinical Field
Authors: Sitepu Rehmadanta , Hendra Godeliva Adriani , Susanto F.X. Haryanto , Nirwana Aditya
Published: October 2022

The pandemic of COVID-19 has forced pharmacist assistance practitioners to strive to improve their qualifications and competencies, especially in molecular biology. The human resources competencies in this field are still lacking, resulting in some obstacles in the handling of COVID-19 encountering, thus hampering the acceleration of post-pandemic recovery. The Virus that can spread rapidly requires competent health workers to move as quickly as possible to overcome this pandemic condition. Ignorance of these critical technical matters often occurs so that it affects the identification results, which are expected to be more accurate, precise, and reliable. In a workforce to increase the competency capacity of pharmacist assistants in the biomolecular field, especially in the technical competence of genetic material isolation and PCR methods, the Pharmacy Study Program of Ma Chung University held Webinars and Workshops related to DNA isolation and quality testing. The webinar and workshop on the isolation of genetic material were carried out to implement one of the research topics in the Pharmacy Study Program, especially in the field of development of molecular biology. The essential thing in this webinar and workshop is discussing some critical criteria before the actual virus identification. This program collaborates with PAFI (Indonesian Pharmacy Experts Association) of Batu City as a partner. People who took part in this event consisted of 63 persons from the Batu City and Malang City areas. Most of the participants work in health facilities, with 50% of the participants having isolated genetic material and PCR (Polymerase Chain Reaction). Spreading the pre and post-test with the same questions increased the average acknowledgment score from 42.9 to 61.1. This indicates that continuous training in this field needs to be held on an ongoing program so that the competence of pharmacists in the field of molecular biology is getting better.
Clustering by Health Professionals in Individually Randomised Controlled Trials
Authors: Waleed Mohammad , Kazmi Isma , Farooq Mishah , Hamid Abdul , Karam Fazal , Allgar Victoria , Wong Kenneth Y.K.
Published: October 2022

Purpose: The aim of this study was to investigate the prevalence of clustering by health professionals in individually randomised controlled trials (iRCT), and its adjustment in both the sample size calculation estimates and the analysis of the data collected in iRCT (that is, trials that randomise individuals only). As a result, cluster randomised controlled trials will not be the part of this review study. Additionally, the authors aimed to discover the prevalence of the various forms of clustering in iRCT.

Methods: iRCT, in which the intervention was delivered by a health professional, were electronically searched in three medical journals. The dates searched were from 1st January 2000–31st August 2009. The retrieved trials were then screened to exclude those with complex designs and trials with more than two parallel arms. The selected trials were then fully reviewed for the presence of clustering effects and any corresponding adjustment. Data about the sample size calculation in the selected trials were also included. A basic form was generated for the purpose of data extraction from each of the selected trials.

Results: Of the 130 iRCT reviewed, clustering of outcomes was present in 127 (98%) trials. Only 61 trials (47%) had adjusted for the clustering effects in their design and analysis, while 53% of the trials had ignored the clustering effect, and hence no adjustment had been made in the trial design or analysis.

Regarding the various forms of clustering, clustering by centre in multicentre trials was found in 79 trials (60%), followed by natural clustering in 26 trials (20%), and clustering imposed by the design of the study in 23 trials (18%).

Conclusion: Potential clustering of outcomes exists in almost all iRCT; however, this review found that <50% of iRCT took clustering into account and adjusted the sample size calculation and statistical analysis of this data for clustering. Almost half of the reviewed iRCT ignored the clustering effect. As a result, inaccurate and nongeneralisable results could have been generated.
Drug Allergy: Delayed Cutaneous Hypersensitivity Reactions to Drugs
Authors: Hamm Rose L.
Published: October 2022

Drug allergies, also termed adverse drug reactions (ADRs), are a problem for individuals of all ages, from paediatric to geriatric, and in all medical settings. They may be a predictable reaction to a specific drug (termed Type A) or particular to the individual (termed Type B). Health professionals, especially those caring for patients at the point of entry into the medical system, have a very important role in determining if and when a patient is having an ADR. The purpose of this article is to review the pathophysiology of ADRs, describe the signs and symptoms of different classifications of ADRs, and present the medical and wound treatment for patients with systemic and cutaneous reactions to drug allergies.
Cardiac Rehabilitation in Heart Failure: Looking Further Ahead
Authors: Vilela Eduardo , Ladeiras-Lopes Ricardo , Silva Marisa , João Ana , Torres Susana , Campo Lilibeth , Miranda Fátima , Fonseca Marlene , Caeiro Daniel , Primo João , Ribeiro José , Sampaio Francisco , Fontes-Carvalho Ricardo , Teixeira Madalena , Braga Pedro
Published: October 2022

Heart failure (HF) is associated with significant morbidity and mortality. Despite major advances in the treatment of HF, there are still important unmet needs among this patient population. Cardiac rehabilitation has a central role in cardiovascular prevention and for overall disease management, and can have an important impact among HF patients. The authors present a brief overview on the current role of cardiac rehabilitation among HF patients in a contemporary setting and discuss some areas of future research in the context of this intervention.
The Brussels Effect and Artificial Intelligence
Authors: Siegmann Charlotte , Anderljung Markus
Published: October 2022

The European Union is likely to introduce among the first, and most comprehensive AI regulatory regimes of the world’s major jurisdictions. We ask whether the EU’s upcoming regulation for AI will diffuse globally, producing a so-called “Brussels Effect”. Extending Anu Bradford’s work, we outline the mechanisms by which such regulatory diffusion may occur. We consider both the possibility that the EU’s AI regulation will incentivise changes in products offered in non-EU countries (a de facto Brussels Effect) and the possibility it will influence regulation adopted by other jurisdictions (a de jure Brussels Effect). Focusing on the proposed EU AI Act, we tentatively conclude that both de facto and de jure Brussels effects are likely. A de facto effect is particularly likely to arise in large US tech companies with “high-risk” AI systems. The upcoming regulation might be important in offering the first operationalisation of developing and deploying trustworthy AI.
Traducción y adaptación cultural al español del cuestionario PATS
Authors: Rojo Ramos Jorge , Gómez Paniagua Santiago , Carlos Vivas Jorge , Adsuar José Carmelo
Published: October 2022

Durante estos dos últimos años la pandemia originada por la COVID-19 ha tenido consecuencias fatales para el turismo, llevando a los investigadores y expertos a buscar soluciones ante una nueva situación epidemiológica. La aparición del cuestionario Pandemic (COVID-19) Anxiety Travel Scale (PATS) permite valorar la ansiedad previa a viajar, evaluando problemas de salud cognitivos relacionados con la pandemia y encontrándose adaptada al sector turístico. El objetivo de este estudio es traducir y adaptar a español la escala PATS. El procedimiento utilizado fue la adaptación transcultural de la versión original del documento mediante traducción directa al español e inversa al inglés. Se obtuvo la versión española de la escala PATS sin identificarse ningún ítem como conflictivo. El cuestionario PATS ha demostrado ser una herramienta potencialmente útil, rápida (5 ítems) y fácil de administrar para identificar la ansiedad previa a los viajes en diferentes sectores de la población.
СОФИНИАНСКАЯ МЕТОДОЛОГИЯ В СВЕТЕ МЕХАНИЗМА ФУНКЦИОНИРОВАНИЯ ТРАДИЦИИ
SOPHINIAN METHODOLOGY IN THE LIGHT OF THE MECHANISM
OF THE FUNCTIONING OF TRADITION
Authors: Кириченко Олег Викторович
Published: October 2022

Статья посвящена новой в гуманитарной науке теме – софинианской методологии. Новизна состоит в том, что софинианство хотя и было рабочей моделью для некоторых русских мыслителей XX в., таких как А. Ф. Лосев, М. М. Бахтин и Д. С. Лихачев, но разрабатывалось ими не как теория, а как метод для решения конкретной научной задачи. Софинианская диалектика Лосева, теория диалога Бахтина, духовная культурология Лихачева лишь открывают возможности для более общего и единого в своей теоретической цельности понимания софинианской методологии. Но до сих пор нет понимания, какой инструментарий нужен для софинианской методологии, каковы особенности функционирования ее в рамках традиции и модерна и т. д. Статья подготовлена на основе лекций, прочитанных автором в РГГУ в 2020–2022 гг., потому сохраняет облегченную форму презентации теоретического материала.
The article is devoted to a new topic in the humanities – Sophinian methodology. Its novelty lies in the fact that Sophinianism, although it was a working model for some Russian thinkers of the 20th century, such as A. F. Losev, M. M. Bakhtin and D. S. Likhachev, but they developed it not as a theory, but as a method for solving one specific scientific problem. Losev's Sofinian dialectics, Bakhtin's theory of dialogue, Likhachev's spiritual culturology only open up possibilities for something more general and unified in its theoretical integrity. But there is still no understanding; what tools are needed for the Sophinian methodology, what are the features of its functioning within the framework of tradition and modernity, and much more. The article was prepared on the basis of lectures given by the author at the Russian State Humanitarian University in 2020-2022. and therefore its material retains a lightweight form of presentation of the material. In this case, the theoretical material.
Automatic assessment of roofs conditions using artificial intelligence (AI) and unmanned aerial vehicles (UAVs)
Authors: Alzarrad Ammar , Awolusi Ibukun , Hatamleh Muhammad T. , Terreno Saratu
Published: October 2022

Building roof inspections must be performed regularly to ensure repairs and replacements are done promptly. These inspections get overlooked on sloped roofs due to the inefficiency of manual inspections and the difficulty of accessing sloped roofs. Walking a roof to inspect each tile is time-consuming, and as the roof slope increases, this difficulty increases the time needed for an inspection. Moreover, there is an intrinsic safety risk involved. Falls from roofs tend to cause severe and expensive injuries. The emergence of new sensing technologies and artificial intelligence (AI) such as high-resolution imagery and deep learning has enabled humans to move beyond the concept of using manual labor in damage assessments. It has brought significant advantages in the field of safety management, and it can be a substitute for the traditional assessment of roofs. This study uses unmanned aerial vehicles (UAVs) and deep learning technology to perform sloped roof inspections effectively, thus eliminating the safety risk involved in traditional manual inspections. This study utilizes UAVs and deep learning to automatically collect and classify roof imagery to identify missing shingles on the roof. The proposed research can help real estate agents, insurance companies, and others make better and more informed decisions about roof conditions. Future research could be refining the model to deal with different types of defects in addition to missing shingles.
A visualization system for erectile vascular dynamics
Authors: Fujimoto Kota , Hashimoto Daiki , Kashimada Kenichi , Kumegawa Shinji , Ueda Yuko , Hyuga Taiju , Hirashima Tsuyoshi , Inoue Norimitsu , Suzuki Kentaro , Hara Isao , Asamura Shinichi , Yamada Gen
Published: October 2022

Erection is an essential process which requires the male penis for copulation. This copulatory process depends on the vascular dynamic regulation of the penis. The corpus cavernosum (CC) in the upper (dorsal) part of the penis plays a major role in regulating blood flow inside the penis. When the CC is filled with blood, the sinusoids, including micro-vessels, dilate during erection. The CC is an androgen-dependent organ, and various genital abnormalities including erectile dysfunction (ED) are widely known. Previous studies have shown that androgen deprivation by castration results in significantly decreased smooth muscles of the CC. Experimental works in erectile biology have previously measured intracavernosal penile pressure and mechanical tension. Such reports analyze limited features without assessing the dynamic aspects of the erectile process. In the current study, we established a novel explant system enabling direct visual imaging of the sinusoidal lumen to evaluate the dynamic movement of the cavernous space. To analyze the alternation of sinusoidal spaces, micro-dissected CC explants by patent blue dye injection were incubated and examined for their structural alternations during relaxation/contraction. The dynamic process of relaxation/contraction was analyzed with various external factors administered to the CC. The system enabled the imaging of relaxation/contraction of the lumens of the sinusoids and the collagen-containing tissues. Histological analysis on the explant system also showed the relaxation/contraction. Thus, the system mimics the regulatory process of dynamic relaxation/contraction in the erectile response. The current system also enabled evaluating the erectile pathophysiology. In the current study, the lumen of sinusoids relaxed/contracted in castrated mice similarly with normal mice. These results suggested that the dynamic erectile relaxation/contraction process was similarly retained in castrated mice. However, the system also revealed decreased duration time of erection in castrated mice. The current study is expected to promote further understanding of the pathophysiology of ED, which will be useful for new treatments in the future. Hence, the current system provides unique information to investigate the novel regulations of erectile function, which can provide tools for analyzing the pathology of ED.