bluuebunny/crossref_metadata_2025 huggingface dataset:
CORRECTION OF ANTIOXIDANT SYSTEM STATE IN PATIENTS WITH MICROBIAL ECZEMA
Authors: Tlish M. M , Popandopulo Elena K.
Published: January 2021

Antioxidant system dysfunction is a significant factor in the pathogenesis of inflammatory dermatosis. Despite an impressive number of studies on the causes and chronization of microbial eczema, the development of a comprehensive approach to therapy taking into account metabolic disorders remains a pressing task. Material and metods. In the course of this study, the effectiveness and expediency of including in microbial eczema therapy a preparation of antioxidant action of dimethyloxobutylphosphonyldimethylate (DFD) was evaluated based on the dynamics of antioxidant system dysfunction indices, markers of syndrome of endogenous intoxication and clinical manifestations. The material for the study was the blood of patients with microbial eczema taken before and after treatment. Dynamics of parameters of enzymatic and non-enzymatic units of antioxidant system dysfunction, level middle mass molecules were analyzed against the background of standard therapy and with inclusion of DFD. Results. Inhibition of antioxidant system dysfunction activity compared to the control group was detected in the blood of all microbial eczema patients prior to treatment. No antioxidant status was observed after the standard therapy course despite achieving clinical improvement. The inclusion of DFD in complex microbial eczema therapy had a positive effect on the state of antioxidant system dysfunction and the dynamics of the skin pathological process.
PERSONALITY TRAITS OF PATIENTS WITH SENSITIVE SKIN SYNDROME
Authors: Nikolayeva Natalya N.
Published: January 2021

The sensitive skin syndrome as a manifestation of a sensitive personality at a biological level is considered. The research is based on the four-level structure of an individual (biological, psychological, social and spiritual). The results of the study based on the data from the questionnaire of temperament accentuation provided by patients with sensitive skin syndrome (based on the concept of accented personalities by K. Leonhard) are presented. The factor analysis of the obtained data for 107 patients with sensitive skin syndrome in contrast to 30 people with normal skin showed increased indicators on the scales of “sensitivity” (0.82), “timidity” (0.78), “neuroticism” (0.76), “emotional lability” (0.7). As well as the absence of an increase in the scales of “hypertimacy” (-0.7), “social activity” (-0.8) and “vigor” (-0.7) was noted. Three factors (“sensitivity”, “neuroticism” and “social passivity”), reflecting the combination of temperament accentuation and global character features of these individuals, were distinguished. Data for people with normal skin, in contrast to people with sensitive skin, demonstrate an increase in the scales of “social activity” (0.9) and “vigor” (0.78). At the same time, there is no increase in the scales of “timidity” (-0.78) and “emotional lability” (-0.8). As a result, two factors were distinguished (“social activity” and “emotional balance”). Thus, both psychological and somatic aspects were significant in sensitive skin syndrome diagnostics. Individual personal traits and the emotional state are closely connected with the skin condition, which requires complex treatment and timely psychotherapeutic help for patients with sensitive skin syndrome.
Clinical observation of two cases of Gottron skin carcinoid papillomatosis
Authors: Kovaleva Yulia S. , Kuropyatnikova O. R.
Published: January 2021

The article presents modern and historical data of domestic and foreign literature on rare severe dermatosis Gottron skin carcinoid papillomatosis. Two own clinical observations of Gottron skin carcinoid papillomatosis in a young woman of 48 years proceeding against the background of malignant neoplasm of the ovary, and a man of 70 years with a concomitant vascular disease of the lower extremities are described.
Photo gallery of onychodystrophies
Authors: Maksimov Ivan S.
Published: January 2021

Onychodystrophies are various pathological processes in the nail apparatus of infectious and non-infectious nature, related to changes in its morphology. The most common cause of nail changes is a fungal infection. However, onychodystrophy can be a manifestation of dermatological diseases, trauma, medication, systemic and tumor processes. Since the clinical symptoms of onychodystrophies are unspecific, sometimes it can cause difficulties in making a diagnosis. This photo gallery presents clinical pictures of diseases that a physician may encounter in everyday practice.
Transdermal redermalization in rosacea: Rehab procedures in intercurrent period
Authors: Romashkina Anastasia S. , Olisova O. Y. , Snarskaya E. S.
Published: January 2021

Background: The authors presented their own experiences of skin restoration in patients with rosacea after a course of active therapy using transdermal redermalization.
Aim: The course of cosmetic correction procedures using this method aimed to restore the energy potential of cells, water balance, and structures of the dermal elastin fibers, normalize microcirculation processes, and create an optimal physiological environment for the mitotic activity of epidermal cells.
Materials and methods: An innovative method of transdermal redermalization represents the administration of a drug containing hyaluronic acid and sodium succinate using the technique of papular intradermal injections, taking into account the peculiarities of lymphatic drainage in the facial area.
Results: To assess the therapys efficiency, noninvasive monitoring of changes in morphological structures of the skin was performed using confocal laser scanning microscopy.
Conclusions: The authors revealed the high efficiency of the method, which controls the remission state for a long term, subsequently avoiding drug therapy
Pyoderma gangrenosum of the hand: a missed diagnosis and lessons learned
Authors: Maheshwari K. , Yousif A. , Burova E.
Published: January 2021

INTRODUCTION: Pyoderma gangrenosum (PG) is a challenging condition to diagnose and treat.

CASE REPORT: We discuss the case of a man who presented with a swollen and extremely tender finger, with bullous lesions, erythema, and a clinical picture suggestive of a necrotising fasciitis. He had a history of ulcerative colitis (UC) and had been taking azathioprine. Initial debridement of the affected tissues was carried out as an emergency, with no improvement. Pyoderma gangrenosum had been suspected at that stage and the patient was prescribed oral Prednisolone. He showed a remarkable recovery and his finger healed completely. Due to a persistent pancytopenia he underwent further tests and was subsequently diagnosed with Acute myeloid leukaemia (AML).

DISCUSSSION: Pyoderma gangrenosum is a diagnosis of exclusion. It can be a sign of internal malignancy and other medical conditions. Therefore, a low threshold must be kept for the diagnosis of this disorder, especially in patients with known risk factors.

CONCLUSION: Based on our experience, in similar clinical scenarios, we suggest limb elevation and antibiotics initially, with a close observation and consideration of the diagnosis of pyoderma gangrenosum prior to any surgical intervention. A thorough investigation of the possible reasons for PG is vitally important.
The efficacy of platelet-rich plasma therapy in the treatment of androgenetic alopecia: a literature review
Authors: Lepehova A. A. , Potapova Maria B.
Published: January 2021

Androgenetic alopecia is a genetically determined disease characterized by gradual thinning of hair, which subsequently leads to hair loss, and thereby significantly affects a patients quality of life. The existing methods of disease management have a number of side effects and drawbacks. Thus, new treatment methods combining both high tolerance and efficacy are continuously determined. This current review presents an analysis of the effectiveness of single- and double-spin preparation methods of platelet-rich plasma for the management of patients with androgenetic alopecia.
Evaluation of the effectiveness of long-term interruption and resumption of therapy with ustekinumab in psoriasis patients with metabolic disorders
Authors: Rychkova Irina V. , Pritulo O. A. , Maraqa Marwan Yakin Naje , Babanin V. A.
Published: January 2021

BACKGROUND:Psoriasis is a chronic immune-mediated inflammatory skin disease. The goal of psoriasis therapy is to achieve long-term stable remission and improve the patients quality of life. Continuity of therapy is the basis for successful disease control. To achieve this goal, the most effective genetic engineered biological drugs are currently used. However, in some patients the biologicals demonstrated insufficient effectiveness. The presence of comorbidities, in particular metabolic syndrome in such cases, is one of the reasons for low therapeutic response.
AIM:This study aimed to evaluate the therapeutic effectiveness of ustekinumab in psoriasis patients with metabolic syndrome after a long interruption and resumption of therapy.
MATERIALS AND METODS:We observed 68 patients diagnosed with advanced plaque psoriasis. They were divided into two groups according to their body mass index and metabolic disorders.
RESULTS:By week 24, 96.8% of the patients in group 1 and 91.6% in group 2 reached PASI 75. By week 48, 100% of the patients in group 1 and 86.1% in group 2 reached PASI 75. By week 76, PASI 75 was observed in 96.8% of patients receiving 45 mg of ustekinumab and in 83.3% of patients receiving 90 mg of ustekinumab. Treatment with ustekinumab was discontinued at week 76 due to economic factors. The therapy was discontinued for 36 weeks. By week 112, 86.7% of the patients in both groups had a relapse of psoriasis, which was assessed by the loss of therapeutic response. By week 124 (12 weeks after the resumption of therapy), PASI 75 was reached in 93.7% of the patients in group 1 and 77.7% in group 2. By week 136, all patients in group 1 had achieved PASI 75, and by week 128, 83.3% of patients in group 2 had PASI 75.
CONCLUSIONS:In patients with psoriasis on ustekinumab therapy, a long-term (36 weeks) interruption and resumption of therapy is possible. However, in patients with comorbid pathology, effectiveness is dimi-nished; thus, new methods of pathogenetic therapy to correct metabolic disorders are needed.
Cutaneous аngiitis
Authors: Teplyuk N. P. , Grabovskaya O. V. , Kolesova Yuliya V.
Published: January 2021

The clinical manifestations of various forms of vasculitis are presented with short comments to each photo.
Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area
Authors: Snarskaya Elena S. , Semenchak Yulia A.
Published: January 2021

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem.
Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented.
Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome.
Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.
Biological drugs prescription issues in terms of the new coronaviral infection COVID-19 pandemic. Literature review and clinical case
Authors: Kruglova L. S. , Shatokhina E. A. , Polonskaya Alexandra S.
Published: January 2021

BACKGROUND:The spread of the novel coronaviral infection has set important medical society goals, such as the development of effective treatment and preventive modalities (including biologic agents) for COVID-19. Moreover, during this pandemic, the management of chronically ill patients that require immunosuppressive therapy is also a matter of great concern. Analysis of currently obtained data has concluded that patients treated with biologic agents have no elevated risk for COVID-19. Leading medical societies give an opinion in their clinical guidelines that management with biologic drugs should be continued during the COVID-19 pandemic. The feasibility of initiating treatment with a biologic agent depends on the risk-benefit ratio for the drug, the assessment of possible complications along with the associated risks for a poor outcome because of an underlying disease.
CASE REPORT:We present a case report of a patient with erythrodermic psoriasis and psoriatic arthritis treated with ixekizumab during COVID-19 quarantine.
Clinical symptoms of the effectiveness of combination therapy for onychomycosis of dermatomycete etiology
Authors: Yakovlev Alexey B. , Golanova O. A.
Published: January 2021

Onychomycosis is widespread all over the world. The choice of treatment tactics continues to be a difficult task for dermatologists. The use of combination therapy showed high clinical and mycological results of treatment, and also reduced the risk of relapses after discontinuation of therapy. Evaluation of the effectiveness of this therapy is based on knowledge of the reverse development of clinical symptoms.
Spinal muscular atrophy type 1: current status of the issue
Authors: Bondar Valeriya A. , Borisov Ilya V. , Kanarskii Mikhail M. , Nekrasova Julia Y.
Published: January 2021

The development of medical technologies has led to an increase in the survival of patients with spinal muscular atrophy (SMA). In turn, these drugs have a high cost, which limits their availability for children with SMA. This fact posed new challenges for the science community. Currently, clinical trials of the effectiveness of drugs for the treatment of various types of spinal muscular atrophy are underway. Clinical forms of SMA are grouped into 5 subtypes depending on the severity of the disease and the age of onset of the disease. Type 1 spinal muscular atrophy, or Werdnig-Hoffmann disease, is the most common, accounting for 60% of all cases of the disease. The first positive results of clinical trials of two potentially new and effective drugs Zolgensma and Risdiplam were published recently. Despite this, the inaccessibility of treatment of spinal muscular atrophy creates a serious interdisciplinary problem at the state level, including medical and social rehabilitation, which is important to understand when planning medical care.
Glycogen-storage disease type 1: medical and social alertness
Authors: Gimaev Ilia A. , Bondar Valeriya A. , Lushnikova E. J. , Borisov Ilya V. , Kanarskii Mikhail M. , Nekrasova Julia Yu.
Published: January 2021

Orphan hereditary pathologies are an urgent medical problem. Metabolic diseases have a special place among them. Currently they include about 500 nosological forms, in particular glycogen diseases. Type 1b glycogen disease (GB1b) occupies a special place. In addition to metabolic disorders, patients with this disease have severe neutropenia, which leads to frequent recurrent infectious diseases, such as stomatitis, periodontitis, furunculosis, otitis, colitis, gingivitis. In addition, recent studies showed the presence of lymphocytic dysregulation in patients with GB1b which is associated with T-regulatory lymphocytes dysfunction. It leads to an increased risk of developing autoimmune diseases, such as autoimmune thyroiditis, myasthenia gravis, Crohns disease, ANA-associated vasculitis. In addition, there is evidence about the association of GB1b and oncological pathologies, such as giant bone cell tumor, acute myeloid leukemia. According to such a wide variety of clinical manifestations, knowledge of the pathogenesis and possible non-metabolic manifestations is necessary for proper diagnostics and therapy.
Using neuroenergy mapping to build a personalized approach to cognitive rehabilitation of patients with vascular lesions of the brain
Authors: Fry Alexandra V. , Vorontsova Viktoriya S. , Pichugina Irina M.
Published: January 2021

The article describes the method of neuroenergy mapping as a way to identify the functional impairment of a structural structural brain in cognitive disorders, which in turn allows instrumental confirmation and justification of the causes of changes in neuropsychological status, as well as individually selected cognitive load, taking into account sex, age and characteristics of the lesion the brain of the patient. In patients using the NEC method in 5 standard leads, the state of brain energy activity was recorded. Then he was offered tasks from the album for a neuropsychological examination of A.R. Luria as a cognitive load: in memory, the elimination of superfluous, storytelling and others. After completion of the cognitive load, the indicators of the patients brain energy activity were again recorded. According to the results of data processing, patients were adjusted recommendations for cognitive load.
Neural network analysis of heart rhythm variability for diagnosis of immobilization syndrome and objectivization of effectiveness of early rehabilitation
Authors: Nekrasova Julia Yu. , Yankevich D. S. , Kanarsky М. М. , Markov A. S.
Published: January 2021

The article discusses the use of a neural network analysis of heart rate variability for the diagnosis of immobilization syndrome and post-intensive care syndrome (PICS) in patients with disorders of consciousness for monitoring the quality of the rehabilitation process. It is shown that there are statistical differences between the curves characterizing the heart rate variability of healthy patients and patients with impaired consciousness. The use of a neural network allows to automatically evaluate the severity of the immobilization syndrome and Post Intensive Care Syndrome, as well as the effectiveness of measures for their prevention and the overall quality of the work of medical personnel.
Sternomastoid after cardiac interventions (questions treatment and rehabilitation)
Authors: Kosenkov Alexandr N. , Vinokurov Ivan A. , Al-Usef Amjat Nasr
Published: January 2021

Sternomediastinitis is one of the formidable complications of cardiac surgery with high disability mortality up to 40%. The introduction of a vacuum-assisted dressing, as well as active surgical technologies in the treatment of these patients, have reduced the duration of hospitalization, the level of disability and mortality. However, a number of unresolved issues remain related to the rehabilitation of these patients.
Health education is the foundation of a healthy society. Need to inform disabled people
Authors: Mironova-Hodorovich Alena Y. , Kiseleva Ekaterina V.
Published: January 2021

It is impossible to change peoples attitude to their health without the help of the most powerful tool for forming public opinion the media. Television, radio and the press, performing educational, informational, cultural and spiritual functions, can increase the interest of the population in maintaining a high level of their own health.
Quality of life as a criterion of o rehabilitation efficiency (on the example of patients with spine osteochondrosis)
Authors: Petrova N. G. , Yarovaya V. A.
Published: January 2021

Background. Degenerative dystrophic diseases (DDD) of the spine occupy a leading place in the structure of the causes of chronic back pain. The widespread prevalence of osteochondrosis and high primary disability determine the medical, social and economic significance of the problem. An important direction of its solution is a scientifically based system of rehabilitation measures. The existing wide arsenal of means of rehabilitative impact dictates the need to assess their effectiveness, for which, in turn, various techniques can also be used. The aim of the study was to assess the quality of life of patients with osteochondrosis before and after rehabilitation. Materials and methods. The patient sample included 50 people with diagnosis of osteochondrosis of the spine. In the structure of respondents, 58.0% were women, 42.0% men. The proportion of individuals: up to 30 years old was 26.0%; 3145 years old 58.0%; 46 years and older 14.0%. 48.0% of patients are diagnosed with cervical spinal dislocation; 10.0% of patients thoracic; 18.0% of the lumbar spine 24.0% of patients common osteochondrosis. 96.0% of patients received rehabilitation measures. They were complex and included drug therapy (100.0%), manual therapy (56.0%), massage (58.0%), healing fitness (24.0%), physiotherapy (amplipulse therapy-10.0%; electrophoresis 6.0%; laser therapy 6.0%), etc. After treatment, the majority of patients (56.0%) had positive dynamics, 28.0% did not have dynamics, and 16.0% were negative. An analysis of the quality of life of patients before and after rehabilitation measures showed the following. Results. The total score (GH) increased from 64.6 to 67.6 points. The physical component increased from 47.5 to 51.8 points; psychological from 45.1 to 45.6 points. The dynamics of these indicators differed among patients of different sexes, ages, with different diagnoses. Conclusions. Assessing the quality of life using the questionnaire allows you to objectify the effectiveness of the treatment.
Features of the structure of adult disability due to hypertension
Authors: Odebaeva Roza , Achkasov Evgeniy E. , Shurgaya Marina А.
Published: January 2021

A retrospective statistical analysis of primary, repeated and General disability of the adult population in Moscow and in the Russian Federation was carried out. The observation period 20112017. Scope of the study: 31 373 disabled people (primary 11 069 and repeated 20 304), recognized as disabled due to hypertension during examination in the BMSE. The analysis of the dynamics of disability due to all classes of diseases in the Russian Federation is carried out. The total population was 324 832 people (90 808 primary and 234 024 repeated), who were recognized as disabled due to hypertension during examination in the BMSE. The observation period 20112017. The features of clinical and functional disorders and limitations of life activity in disabled people due to essential arterial hypertension (hypertension) were studied. A sample study was conducted in a cohort of disabled people (271 people due to hypertension).
Results of sclerotherapy for recurrent and non-recurrent nodular goiter
Authors: Rodoman Gю V. , Shalaeva T. I. , Sumedi I. R. , Sviridenko N. V. , Meloyan M. M.
Published: January 2021

Background. The problems of treating recurrent nodular goiter are still relevant. The technical difficulties of the intervention on the neck tissues altered by the scarring process and the comorbid background of patients cause an unacceptably high risk of complications of traditional surgical treatment and, as a result, a long and difficult rehabilitation period and high costs for the treatment of patients who have undergone surgery for recurrent goiter. Alternative methods, such as sclerotherapy, which reduce the risk of complications, have been successfully used in patients with non-operated thyroid, but the possibilities of minimally invasive destruction of recurrent nodules have not been studied enough, and it is not known whether it is as safe and effective as sclerotherapy of non-recurrent nodules. The aim of the study was to compare the efficacy and safety of treatment of recurrent and non-recurrent nodular goiter using sclerotherapy. Materials and methods. The study included 30 previously not operated patients with nodular goiter and 30 patients with recurrent nodular goiter. All of them underwent 4 courses of sclerotherapy, each of which included 5 sessions with a frequency of 1 session per week; polidocanol was used as a sclerosant. Results. The analysis showed that the efficiency of reduction of nodules did not decrease in patients with recurrent goiter, despite severe sclerotic changes in the tissues. The size of the nodules and the volume of thyroid tissue were reduced during sclerotherapy, regardless of the presence of a history of thyroid surgery, as well as the cure of functional autonomy and relief of symptoms of neck compression. The tolerability of sclerotherapy also did not depend on the presence of recurrent goiter, and the rate of complications was the same (0.8%). Complications of sclerotherapy were not serious in any case. Conclusions. Thus, sclerotherapy of recurrent nodules is a good alternative to traditional surgical treatment; it is not inferior in efficiency and safety to sclerotherapy of nodules in a non-operated thyroid. Its use will significantly reduce the rehabilitation period and the cost of treating patients with recurrent nodular goiter.
Treatment of an extensive acetabular defect in a patient with aseptic instability of a total hip arthroplasty
Authors: Aleksanyan Hovakim A. , Chragyan Hamlet A. , Kagramanov Sergey V. , Zagorodniy Nikolay V.
Published: January 2021

The aim of the study is to demonstrate, using a clinical example, the possibility of treating a patient with a severe acetabular defect by performing a one-stage revision arthroplasty using an individual design.
Materials and methods. A 45-year-old female patient was admitted with complaints of pain, limitation of movement in the right hip joint, and gait disturbance. From anamnesis at the age of 5 years, reconstructive operations of the hip joints were performed. In 1991, CITO performed primary total arthroplasty of the right hip joint with an endoprosthesis from ESKA Implants. In 1998, due to the instability of the acetabular component of the total endoprosthesis of the right hip joint, revision arthroplasty was performed, and the cup was placed with a cement fixation. In 2001, for left-sided dysplastic coxarthrosis, primary total arthroplasty of the left hip joint was performed. In 2012, due to the instability of the total endoprosthesis of the left hip joint, revision arthroplasty was performed using an ESI anti-protrusion ring (ENDOSERVICE) with a cement cup and a Zweimller-type femoral component; the femur defect was repaired using a fresh frozen cortical graft. In October 2019, instability of the total endoprosthesis of the right hip joint was revealed, for which revision endoprosthetics was performed using an individual acetabular component.
Results. The HHS index before revision arthroplasty was 21 points, after 1 month after surgery 44 points, after 3 months after surgery 65, after 6 months 82. Quality of life was assessed according to the WOMAC scale: before surgery 73 points, after 1 month after surgery 54 points, after 3 months 31, after 6 months 15 points. At the time of the last consultation, the patient moves with a cane, lameness persists, associated with scar reconstruction and atrophy of the gluteal muscles.
Conclusion. The use of individual structures allows to restore the support ability of the lower limb and the function of the hip joint in the case of an extensive defect of the pelvic bones of the pelvic discontinuity type.
Surgical treatment of locally advanced undifferentiated spindle cell paravertebral soft tissue sarcoma. Case report
Authors: Zagorodnii Nikolai V. , Karpenko Vadim Y. , Berchenko Gennady N. , Karasev Anatoly L. , Zelyanin Alexander S. , Akhpashev Alexander A. , Lysenko Ivan S. , Iluridze George D.
Published: January 2021

Abstract: Soft tissue sarcomas are a rare heterogeneous group of malignant tumor of different origin. The small quantity patients with this diagnosis leads to a lack of scientific data on the treatment of such patients. This article presents a clinical case of a patient with spindle-cell paravertebral sarcoma of soft tissues of pelvic localization, who get surgical treatment in the volume of reconstructive plastic surgery with endoprosthesis of the sacroiliac joint.
Effects of Visual Exposure to IQOS Use on Smoking Urge and Behavior
Authors: Brett Emma I. , Miloslavich Krista , Vena Ashley , Didier Nathan , King Andrea C.
Published: January 2021

Objectives: In this study, we examined whether visual exposure to the heated tobacco product (HTP) IQOS, which was authorized for sale by the US Food and Drug Administration in 2019, acts as a cue to increase cigarette craving and smoking behavior among smokers. Methods:
Young adult smokers (N = 105) were randomly assigned to view a video depicting use of either IQOS or bottled water. Main outcomes were changes in cigarette and e-cigarette desire and latency to smoke between the groups. We also examined participants' attitudes about the actors using IQOS and
drinking water in the videos. Results: Exposure to the use of IQOS acutely increased observers' ratings of smoking urge and desire for a cigarette and an e-cigarette. The IQOS cue, compared with the water cue, also produced a marginally significant shorter latency to smoke. Participants
perceived actors as less likeable and friendly when using IQOS than when drinking water. Conclusions: Results showed that exposure to IQOS produced smoking urge and behavior in young adult smokers, implicating IQOS use as a smoking and vaping cue. As HTPs gain popularity, product impact
on passive observers should be included in their risk-benefit profile.
Impact of Covid-19 on Islamic Stock Markets: An Investigation using Threshold Volatility and Event Study Models
Authors: Irfan Mohammad , Kassim Salina , Dhimmar Sonali
Published: January 2021

The Covid-19 is an unexpected event in the world history with substantial socio-economic impact on the global economy. The global financial market was also badly affected as reflected by the extreme volatility as well as weak performances in the stock markets all over the world.  How do the Islamic stock markets in various parts of the world behave during the Covid-19 shock? The objective of this study is to identify the impact of the Covid-19 pandemic as declared by the World Health Organization on the Islamic stock markets. Using the threshold volatility and event study models, the study analyses the impact of the Covid-19 announcement on the Islamic stock indices in the Indian Stock Exchange (represented by the Bombay Stock Exchange - BSE Shariah Index) and Indonesian Stock Exchange (represented by the Jakarta Islamic Indices - JII). With the date of event identified as 11th March 2020, the event window consists of 60, 30, and 20 days. The results show that the BSE Shariah and JII have positive coefficients, with the BSE Shariah Index shows negative response to the announcement of Covid-19 as global pandemic. On the other hand, the JII reacted positively to the event. The study shows the reaction of a stock exchange is dependent on other economic factors unique to the country, resulting in the events impact of the Covid-19 to vary from one country to another.
Modeling Islamic Economics and Finance Research: A Bibliometric Analysis
Authors: Rusydiana Aam , Sanrego Yulizar , Rahayu Solihah
Published: January 2021

This study aims to determine the development map of mathematic model in islamic economics and finance research that is indexed by Scopus and other reputable journal with the keyword "Mathematic model in islamic economics and finance". The data analyzed were 100 selected publications. The development map of mathematic model in islamic economics and finance research analyzed using the VOSviewer application program to find out the bibliometric map. The results showed that the number of publications on the development of mathematic model in islamic economics and finance research indexed Scopus from 1983-2019 experienced a significant increase and the most were published in Journal of King Abdulaziz University: Islamic Economics. Network visualization showed that the map of the development of mathematic model in islamic economics and finance research was divided into 3 clusters. The majority of research is related to modeling of Profit Loss Sharing (PLS) schemes. However, despite the development of using mathematical model in those researches, the approach tends to be adaptive (inductive) from conventional models that already exist. A challenge to review the mainstream model need to be further critically reviewed. Hence, it is necessary for researcher to formulate a mathematical model with a deductive approach that is reduced from Islamic norms or ethics derived from the Alquran and Sunnah.
Islamic Banks’ Stability: Full-Fledged vs Islamic Windows
Authors: Hasan Arief Ichwanul , Risfandy Tastaftiyan
Published: January 2021

Research aims: This paper investigates whether Islamic windows have better stability than full-fledged Islamic banks.Design/Methodology/Approach: A sample of 14 Islamic banks and 19 Islamic windows banks in Indonesia from 2013 to 2018 was used in this study. Both ordinary least squares and panel fixed effects were employed to examine the stability of both Islamic banks’ types.Research findings: Our empirical result suggested that full-fledged Islamic banks were less stable than their Islamic windows counterparts. This result remained consistent after running the model with different estimators and conducting various robustness tests.Theoretical contribution/Originality: Our result implies that Islamic windows could enjoy their market position to maintain stability without converting themselves into full-fledged Islamic banks because the Islamic banking market's current condition is highly competitive.Practitioner/Policy implication: Our empirical evidence supports the Indonesian governments' policy in converting Islamic windows banks into full-fledged Islamic banks if the market's competitive condition is well monitored by the regulators.Research limitation/Implication: This research result is limited only to the Indonesian setting and can be different if the analysis is taken using a sample from other countries.
Giant Choroidal melanoma metastasis to the Liver in Young Woman
Authors:   Irkutsk Regional Clinical Hospital, Novozhilov A.V. ,   Irkutsk State Medical University, Movsisyan M.O. ,   Irkutsk Regional Clinical Hospital, Grigorev S.E. ,   Irkutsk Regional Clinical Hospital,   Irkutsk State Medical University, Grigoryev E.G. ,   Irkutsk State Medical University,   Irkutsk Scientific Centre of Surgery and Traumatology
Published: January 2021

Описывается редкое наблюдение одиночного гигантского метастаза веретеноклеточной меланомы хориоидеи в печень у молодой женщины, которая восемь лет назад, в возрасте 32 лет, перенесла энуклеацию левого глаза по поводу первичной опухоли. Патология печени установлена во время ультразвукового исследования на восьмом месяце беременности, которая была подтверждена во время кесарева сечения. После родоразрешения пациентка направлена в онкологический диспансер, где метастаз меланомы подтвержден гистологически на основании транскутанной пункционной биопсии. Проведены пять курсов химиотерапии без эффекта. Пациентка госпитализирована в отделение портальной гипертензии областной больницы. При тщательном онкологическом обследовании установлен солитарный характер метастаза. Его объем достигал 2338 см3, неизмененной паренхимы – 951 см3. Также проведено детальное изучение ангиоархитектоники печени на основании данных МСКТ-ангиографии и инвазивной селективной целиакографии. Периферические ветви правой печеночной артерии деформированы, фрагментированы с заметной перекалибровкой – злокачественный процесс. Артериальные сосуды левой доли не изменены. Париетальные разветвления прослеживаются на всем протяжении. Правая и срединная вены полностью вовлечены в процесс, левая печеночная вена интактная. Учитывая неэффективность адъювантной терапии, прогрессирование заболевания, выполнена правосторонняя гемигепатэктомия. Ранний послеоперационный период протекал без осложнений. Осмотрена через один год и десять месяцев: качество жизни хорошее.
Study of Maternal and Foetal Outcome in Abruptio Placentae
Authors: Lokhande Vikram , Jadhav Kunal , Kadam Minal , Rawte Suresh
Published: January 2021

Study of Maternal and Foetal outcome in Abruptio Placentae

Introduction: Abruptio placentae (AP) is a significant obstetrical emergency and as per WHO 2009 maternal mortality rates reported due to AP worldwide was 2.1% and fetal perinatal mortality rate was 15%. AP cannot be prevented but maternal and perinatal morbidity and mortality due to AP can be reduced significantly by aggressive management.  

Methods: The present prospective study was conducted to evaluate the outcome of treatment on the perinatal and maternal outcome in Abruptio Placentae patients in a tertiary care hospital from January 2015 to January 2016 amongst 54 pregnant women diagnosed to have abruptio placentae from 28 weeks of gestation and above and all babies delivered. Face-to-face interviews was conducted. Results: Maximum no. of abruptio placentae were unbooked - 37 (69%) and 85% of patients belonged to the less than 30 years of age group. An abruptio placenta was more common in multipara. Anaemia was seen in 21 patients (38%). Anaemia and PIH was seen in 12 patients (23%). 7 patients had fetal distress at the time of admission (13%). Regarding mode of delivery, 50% of patients delivered vaginally by artificial rupture of membrane (ARM) and oxytocin augmentation and 50% underwent caesarean section. Conclusion:  It was concluded that abruptio placentae is still a leading cause of maternal morbidity and mortality that can be reduced with modern management of abruptio placentae, but timely diagnosis and intervention is necessary.

Key Words: Abruptio placentae, maternal mortality, fetal distress, anaemia
Characterization and selection of native yeast isolated from natural fermentation for the production of the artisanal beverage bacanora
Authors: Alvarez-Ainza Maritza Lizeth , García-Galaz Alfonso , Gonzalez-Rios Humberto , De la Torre-Martinez Mayra , Zamora-Quiñones Karina Alejandra , Acedo-Félix Evelia
Published: January 2021

Bacanora is a Mexican distilled beverage made from agave, similar to tequila and mescal, produced with an artisanal process. Therefore the organoleptic characteristics of different bacanora vary highly. The aim of this study was to characterize and select native yeast involved in this artisanal process of fermentation. An initial pre-selection based upon the phenotypic characteristics of 580 strains of yeast was done, and then with fermentation characteristics with agave juice, to select some strains which satisfy with desirable. The Saccharomyces cerevisiae yeasts produced at the end of the fermentation 8.27 ± 0.24 g/L of biomass, 25.51 ± 1.19 g/L of ethanol, with a volumetric productivity of ethanol of 1.76±0.17 g/L/h. While for the three strains non-Saccharomyces the parameters were 3.86 ± 1.14 g/L, 15.56± 1.68 g/L and 0.484±0.06 g/L/h respectively. In the mixed culture of three S. cerevisiae, all remained at the end, but one of them predominates and of non-Saccharomyces yeasts, Torulaspora delbrueckii was the predominant yeast, this according with PFGE results. The results showed that the native yeasts are adapted to the agave juice used for production of bacanora and these yeasts would contribute to improve the ethanol yields and the organoleptic characteristics of Bacanora.
Influencia del nivel nutricional sobre la calidad seminal y el comportamiento sexual de los machos cabríos tratados con días largos artificiales
Authors: Flores Nájera Manuel de Jesús
Published: January 2021

Para evaluar si el nivel nutricional modifica la calidad seminal y el comportamiento sexual de los machos cabríos tratados con días largos artificiales. Diez y seis machos cabríos fueron divididos en dos tratamientos difiriendo en su nivel alimenticio. Un grupo de machos recibió el 75 % de sus requerimientos nutricionales de mantenimiento y reproducción (G-75), mientras que otro grupo recibió el 120 % (G-120). La circunferencia escrotal fue menor en el grupo G-75 que la registrada en el grupo G-120 (P < 0.01). Similarmente, el volumen de eyaculado y el número total de espermatozoides por eyaculado fueron menores en el grupo G-75 (0.5 ± 0.05 mL y 1.9 x 109, respectivamente) que en el grupo G-120 (0.7 ± 0.1 mL y 3.0 x 109, respectivamente; P < 0.001). La motilidad espermática fue menor en el grupo G-75 (2.6 ± 0.1), que en el grupo G-120 (3.2± 0.1; P < 0.001). La latencia a la eyaculación fue mayor en los machos del grupo G-75, que la registrada en el grupo G-75 (P < 0.001). Los resultados del presente estudio indican que, en los machos cabríos tratados con días largos artificiales, la reducción de un 25% de sus requerimientos nutricionales afecto la calidad seminal y el comportamiento sexual.
Rentabilidad y rendimiento de girasol en función del tipo de suelo, nitrógeno y biofertilizante
Authors: AGUILAR CARPIO CID
Published: January 2021

El objetivo de este estudio fue determinar la influencia del tipo de suelo, nitrógeno y biofertilizante sobre la fenología, biomasa total, rendimiento de grano y sus componentes en el cultivo de girasol. El estudio se realizó en el Colegio de Postgraduados, donde se sembró el girasol cv. Victoria. Los tratamientos en estudio fueron dos tipos de suelo en los cuales se aplicó dos niveles de nitrógeno, con y sin biofertilizantes. Se evaluó la fenología de la planta, biomasa total, índice de cosecha, rendimiento y sus componentes. Para los suelos en estudio se encontró que la fertilización nitrogenada y el biofertilizante no modificaron el tiempo a ocurrencia de las etapas fenológicas, pero sí se observó un cambio en la biomasa total y rendimiento de grano, donde la mayor producción se registró con la aplicación de nitrógeno a 100 kg ha-1 y la inoculación del biofertilizante, en condiciones con menor salinidad. El mayor ingreso neto se logró con la aplicación de 100 kg de N ha-1 y biofertilizante, en el suelo con la salinidad más baja.
A therapeutic approach to low-grade serous ovarian carcinoma
Authors:   Department of Oncology, University Hospital Split and School of Medicine Split, Split, Croatia, Petrić-Miše Branka , Šundov Dinka
Published: January 2021

Low-grade serous ovarian cancer (LGSOC) has less aggressive behavior and a better clinical outcome than high-grade serous ovarian cancer (HGSOC). Considering that this malignancy is relatively chemoresistant, surgery is the keystone of treatment, with a strong recommendation for maximal cytoreduction. Women with stage IA-IB disease should undergo observation alone after primary cytoreductive surgery. In contrast, observation, chemotherapy, or endocrine therapy are possible options for those with stage IC-IIA disease. Patients with stage IIB-IV disease receive either chemotherapy with carboplatin and paclitaxel for six cycles followed by endocrine therapy, most commonly with aromatase inhibitors, or endocrine therapy alone until disease progression or unacceptable toxicity. Surgery, chemotherapy, and endocrine therapy are also used in patients with recurrent disease. Targeted agents, especially mitogen-activated protein kinase (MEK) inhibitors and cyclin-dependent kinase (CDK) inhibitors, are currently under evaluation in this clinical setting. Additional research on the genomics of LGSOC to better define the activating gene mutations involved in the carcinogenesis is strongly warranted to improve the prognosis with this malignancy.
Collective Modified Value at Risk in Life Insurance
Authors: Al-Banna Ismail Muhammad Iqbal , Talib Bon Abdul , Talib Bon Abdul , Sukono Sukono , Sukono Sukono , Ronnie Effendie Adhitya , Ronnie Effendie Adhitya
Published: January 2021

Insurance is seen as a tool which individuals can transfer risks to others, where insurance collect funds from individuals to meet financial needs related to damage. Therefore analysis of risk in life insurance claims is really be needed bt the insurance company actuary. In an insurance system, the risk is the event when an insured party puts forward a claim. Claim is the compensation for a risk loss. Individual claim in one period insurance is called aggregation claim while aggregation claim is collective risk
Non-Thermal Millimeter Waves Non-Ionizing Radiation of Saccharomyces Cerevisiae – Insights and Interactions
Authors: Barbara Ayan , Rajput Shailendra , Komoshvili Konstantin , Levitan Jacob , Yahalom Asher , Liberman- Aronov Stella
Published: January 2021

Nonionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85-105 GHz MMW irradiation within the ICNIRP (International Commission on Non-Ionizing Radiation Protection) non-thermal 20 mW/cm2 safety standards. We irradiated using radiation with a power density of about 1.0 mW/cm2 over 5-6 hours on 50 cells/μl samples of Saccharomyces cerevisiae model organism. This resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85-105 GHz range, and was energy and cell density dependent. Irradiation of wild type and Δrad52 (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm2) and compared to that of a compact waveguide (17.17 mW/cm2) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. Combinations of MMW mediated Structure Resonant Energy Transfer (SRET), membrane modulations eliciting signaling effects, and energetic resonance with biomolecules are conjectured to be responsible for the observations reported. Our results suggest innovative applications of nonionizing radiation procedures for yeast related diseases and other targeted biomedical outcomes.
On the Role of Grain Boundaries During Sintering
Authors: Staab Torsten , Helm Ricardo , Diegeler Andreas
Published: January 2021

We present new results in positron annihilation lifetime spectroscopy (PALS), thermo-optical dilatometry and microscopy, which are indicating a strong correlation between grain-boundaries and mass transport during the sintering process of carbonyl iron powder. In this particular system we were able to show that the change in particle shape and size with increasing temperature yields an anisotropy in shrinkage, which manifests itself in a higher shrinkage perpendicular to the compaction axis. In the intermediate stage of sintering, where the major mass transport occurs, the average distance between two grain boundaries could be determined to (3,73 ± 0,18) μm at T = 744°C. This is in good agreement with previous calculations of positron pathways in defect free particles. Furthermore, due to sintering temperatures far above the annealing temperature of dislocations in iron, the existence of dislocations in the bulk of the particles is very unlikely. These claims are reflected by the collected positron data, which exhibit a clear grain boundary signal of ∼ 250ps while no vacancy or dislocation signal (typically ∼ 160 ps) is evident in the intermediate stage of sintering.