bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultra-Compact and Low Delay Time All Optical Half Adder Based on Photonic Crystals
Authors: Parandin Fariborz
Published: November 2022

Photonic crystals are flexible structures that can be used to design a variety of optical devices. One of the important purposes of using photonic crystals is to use them in optical integrated circuits. To design and implement these devices as integrated circuits, they must have both small dimensions and a simple structure. In this paper, an optical half adder is designed using photonic crystals. One of the features of this half adder is its small size. Also, a square lattice has been used in designing this structure, which is simpler than other structures. In designing this structure, it has been tried that the power values in high and low logic modes have a large difference to reduce their detection error at the output. For the sum and carry outputs, the obtained contrast ratio in the designed half adder is 15.4dB and 7.4dB, respectively. The small size of this structure and the use of simple point defects, and their small number have caused the maximum delay time of this structure to be reduced to 0.07ps.
Construction of a base ontology to represent accident expertise knowledge
Authors: SOUNCHIO Serge SONFACK , FOGUEM Bernard KAMSU , GENESTE Laurent
Published: November 2022

Expertise is an activity carried out by experts that contributes to societal progress, as it helps to elucidate unknown situations. Forexample, accident expertise eases accident understanding, by describing how it happened, and by identifying its causes and conse-quences. As a result, the design of accident expertise in a convenient human-machine structure will enable the querying, reasoning,and reuse of accident knowledge in other tools, such as safety and decision-making systems. However, existing representations ofaccident knowledge, such as documents, relational databases, or accident ontologies, do not fulfill accident expertise expectations.Moreover, these representations are unlikely to provide the appropriate use of accident expertise knowledge.
This study presents a base ontology for accident expertise knowledge representation designed with a model-driven methodologyand implemented with semantic web technologies. The study obtained satisfactory results from the evaluation and application ofextension and reuse of this ontology with aircraft accident expertise taken from the French bureau of Enquiries and Analysis (BEA)for civil aviation safety.
Defining and enacting “responsible sexual behavior” in rural Iowa
Authors: Loew Nicole , Mackin Melissa Lehan
Published: November 2022

Objective: Individual level or personal “responsibility” is often implicitly or explicitly used to improve sexual health outcomes. Rural women face unique contextual barriers that increase their risk for poorer sexual health. Therefore, the objective of this study was to understand how rural Iowa women define responsible sexual behavior (RSB) and to identify what contextual variables influence these women’s ability to enact their definitions.
Study Design, Setting, and Participants: This qualitative descriptive study used a semi-structured interview guide to conduct telephone interviews with rural women living in non-core Iowa counties who have had (or planned to have) sex with men. Data were analyzed using within and across case analysis to produce defining and enacting themes of responsible sexual behavior.
Results: Ten women from eight Iowa counties completed telephone interviews. For rural women in this sample, RSB was defined as understanding the consequences of sex and taking action to manage risks by using contraception or abstinence, “knowing” your partner, and seeking knowledge and resources. The rural context influenced how participants acquired information and created barriers to enacting responsible sexual behavior.
Conclusion: Rural women’s definition of responsible sexual behavior did not align with rural values about sexuality. As a result, women often relied on informal information and resources. Emphasizing community-level interventions that act on contextual influences over individual approaches may further assist rural women in enacting responsible sexual behavior.
Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies
Authors: Samec Marek , Mazurakova Alena , Lucansky Vincent , Koklesova Lenka , Pecova Renata , Pec Martin , Golubnitschaja Olga , Al-Ishaq Raghad Khalid , Caprnda Martin , Gaspar Ludovit , Prosecky Robert , Gazdikova Katarina , Adamek Mariusz , Büsselberg Dietrich , Kruzliak Peter , Kubatka Peter
Published: November 2022

Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. Cancer cells rewire metabolism to meet increased nutritional requirements necessary for enhanced cellular proliferation and growth. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation also involves an alteration in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, redox balance, and utilization of ketone bodies as an alternative fuel promoting carcinogenesis. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological phenotype. Recent evidence has identified numerous flavonoids and their derivates as modulators of critical components of cancer metabolism. Flavonoids affect lipid metabolism by regulating fatty acid synthase (FAS) or transcription activity of sterol regulatory element-binding protein 1/2 (SREBP1/2), redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, amino acid flux and synthesis by phosphoglycerate mutase 1 (PGAM1), or ketone bodies generation mediated by 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) in stromal cells to supplement energetic demands of epithelial cancer cells. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies. Flavonoids, which affect metabolic pathways of cancer cells by targeting critical enzymes and transporters, represent a promising avenue to accelerate cancer-related research; however, more in-depth investigation is essential to implement innovative and progressive therapeutic approaches in cancer management.
Development and validation of ferroptosis-related lncRNA features to improve prognosis prediction in ovarian cancer
Authors: Chen Keyu , Ren Xiaojing , Li Xiaohong , Qi Caixia
Published: November 2022

Background: Long non-coding RNAs (lncRNAs) are thought to be associated with several processes during cancer development and have been shown to be involved in the regulation of ferroptosis. Ovarian cancer is highly malignant tumour with a poor prognosis. The identification biomarkers with prognostic value in ovarian cancer may improve patient outcomes and can help to elucidate potential future therapeutic targets.
Methods: We report differential expression of 187 ferroptosis-related lncRNAs in normal and ovarian cancer tissue. Using univariate and multivariable Cox regression analysis, we identified four lncRNAs that were strongly associated with prognosis. We constructed a prognostic risk score based on these four lncRNAs which was effectively able to distinguish between low- and high-risk OC patients based on survival time. Univariate and multivariable Cox regression analyses and time-related receiver operating characteristic curve analyses revealed that this risk score represented an independent prognostic factor in patients with ovarian cancer. And qRT-PCR was performed to further validate the reliability of the prognostic model. For clinical implementation, we developed a nomogram based on the prognostic feature and patient age. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that the four ferroptosis-related lncRNAs were related to tumour immunity. Further immune infiltration analysis was performed to identify multiple immune cells associated with ferroptosis.
Conclusions: we identify four novel ferroptosis-related lncRNAs as predictors of ovarian cancer prognosis and they could be applicable in clinical ferroptosis-related targeted therapies for ovarian cancer.
Effect of long non-coding RNA and DNA methylation on gene expression in dental fluorosis
Authors: Hu Xiaoyan , Li Huiru , Yang Minzhi , Chen Yujiong , Zeng Ailin , Wu Jiayuan , Zhang Jian , Tian Yuan , Tang Jing , Qian Shengyan , 吴 明松
Published: November 2022

In the process of tooth development, the interaction between genetic information, epigenetic inheritance and environment jointly affects the formation of teeth. At present, the mechanism of dental fluorosis is rarely studied from transcriptomics, and there is no report on epigenetic perspective. In the study, SD rats were divided into dental fluorosis group and control group fed with NaF (150 mg/L) or distilled water for 8 weeks. After 3.5 days of birth, the RNAs or DNA of rat mandibular molars were detected by RNA-seq or MethylTarget respectively. The rerults demonstrated that a total of 1723 differentially expressed genes (DEGs) and 2511 differential expression lncRNAs (DE-lncRNAs) were mainly involved in the changes of ion channels, calcium ion transport and immunomodulatory signaling pathways. ATP2C1 and Nr1d1, which were related to Ca2+ transport, cellular calcium homeostasis, endoplasmic reticulum stress and immunity, may be the key genes in the formation of dental fluorosis. Notably, we also found that the immune response plays an important role in the formation of dental fluorosis, and a large amount of DEGs was enriched in immune regulation and NF-κB signaling pathways. Furthermore, the methylation levels of 13 sites were increased in Ago4, Atf3, Atp2c1, Dusp1, Habp4, Mycl while methylation levels of 5 CpG sites decreased in Ago4, Atp2c1, Habp4, Traf6 and conformably the expression of these genes have been significantly changed. This study comprehensively analyzed the occurrence mechanism of dental fluorosis from transcriptomics and epigenetics, so as to provide theoretical reference for further research.
Dissolved-Cl2 Triggered Redox Reaction Enables High-performance Perovskite Solar Cells
Authors: Luo Yujie , Liu Kaikai , Yang Liu , Feng Wenjing , Zheng Lingfang , Shen Lina , Jin Yongbin , Fang Zheng , Song Peiquan , Tian Wanjia , Xu Peng , Li Yuqing , Tian Chengbo , Xie Li-Qiang , Wei Zhanhua
Published: November 2022

Constructing 2D/3D perovskite heterojunction has been proven to be an effective strategy for fabricating high-performance perovskite solar cells (PSCs). However, previous reports only physically deposit a 2D perovskite passivation layer on the 3D perovskite layer. These methods are limited to surface passivation only, and the bulk 3D perovskite remains defective. Herein, we propose Cl2-dissolved chloroform as a multifunctional and reactive solvent for constructing the 2D/3D perovskite heterojunction. Specifically, the dissolved Cl2 reacts with the 3D perovskite, leading to Cl/I ionic exchange. The generated Cl- anions further diffuse to passivate the buried interface of PSCs, improving the bulk and interface quality. Additionally, hexylammonium bromide reacts with the residual PbI2 to form 2D/3D heterojunctions on the surface. As a result, we achieved high-performance PSCs with a champion efficiency of over 24% and substantially improved operational stability, retaining 80% of the initial efficiency after working for 905 h at the maximum power point.
States and Micronations in Cyberspace under Public International Law:
A Legal Analysis of the Case of the Republic of Errant Menda Lerenda
Authors: Zhuk Alesia
Published: November 2022

The purpose of this article is to analyse whether the Republic of Errant Menda Lerenda (¨REML¨) can be considered a micronation or a State under public international law, based on existing doctrine and the actual situation of other states similar to the REML, whose performance in the legal framework of public international law has led to a rethinking of basic postulates. Both cases analyse whether a nation and a State can exist solely in cyberspace. For the purposes of this article, the analysis is based on the following assumptions: 1.- More than one REML can exist, and for the purposes of this conclusion, possible problems arising from the use of the same flag or name are not considered. 2.- It is assumed that the REML that is the subject of this study was created first and is the subject of the document in Appendix 1–3, which is assumed to be correct in date, content and other considerations. 3.- As a working assumption, it is assumed that the REML has a territory (consisting of a sovereign and its space) and that the entire population of the REML is a sovereign.
"Sex Without Sexual Attraction?": Perceived Sexual Experiences of Indian Sex-positive Asexuals
Authors: Agrawal Nandini , Shainy Munna R. , Sebastian Jane , Srivast Akriti
Published: November 2022

Amidst the vast majority of literature that either quantify the extent to which one identifies to be asexual or creates an atomistic perspective of the asexual spectrum which reiterates the false notion that all asexuals are aversive to sex, the current qualitative inquiry aimed to describe the sexual experiences of sex-positive asexuals who are rarely mentioned in academia. Fifteen Indian sex-positive asexuals who have engaged in either self-pleasure or partnered sex, and even both, were recruited for the study. The individual semi-structured interviews that captured their perceptions of their own sexual experiences were thematically analysed to cover the same important phenomena. The experiences associated with developing own identity in terms of sexual activity included self-exploration helping in self-acceptance, feeling of being different and a preference of the type of sexual activities. The participants also reported how their preconceptions about sex based on media and peer engagement differed from what it really was. Emotional experiences during self-pleasure and partnered sex were found to be radically different for most of the participants. Recognising why self-pleasure is important to them and the impacts they believe it had, were commonly observed. It was also found that the participants had a clear understanding of their own roles and the extent of efforts to be put into self-pleasure activities and partnered sex. During the normal human experience of physiological arousal, which is purely based on non-sexual factors about the partner or a potential one, they resort to indulging in sex with them or pleasuring themselves. A dichotomy in terms of the intrinsic and extrinsic reasons for why they indulged in self-pleasure or partnered sex was observed. The results of the study are pivotal in developing inclusive practises, sex education and community awareness about this particular community and, most importantly, enabling representation of their experiences within the academia about sex and sexuality.
Development of modern urban parks on the example of Baotou city
Authors:   Irkutsk National Research Technical University, Jing Hao , Kozlov Valery V. ,   Irkutsk National Research Technical University
Published: November 2022

Abstract. This research aims to identify the principles of developing ecological parks in terms of their integration into the urban structure. Relevant informational materials and scientific publications devoted to modern urban parks were investigated. On the example of the parks built in Baotou сity (Inner Mongolia, China), including the Renmin Baotou, Nanhai Park and Saihantala Ecological Park, specific features of planning and integrating these entities into the urban context were defined. The principles of forming ecological city parks were classified, including: adaptation of the park to local conditions; overall planning of its basic elements; orientation towards bringing people closer to each other and to nature. Key trends in the development of modern urban parks were revealed. The influence of the following groups of factors was established: historical, regional and cultural; functional and behavioural; landscape and ecological. In terms of urban construction and development, the three elements – nature, city and people – are closely intertwined, influencing each other and constituting an organic whole. The establishment of ecological parks in a city contributes towards improving its environment and residents’ health. At the same time, in order to meet future demands, the park’s thematic scope and structure should agree with the city’s urban development strategy. Therefore, when constructing a city park, the strategy of its urban planning should be taken into account.
Assessment of the possibility of calculating the thermal performance of building heating systems using the Autodesk Revit software package
Authors:   Irkutsk National Research Technical University, Moroz Mariya V. , Vityazeva Margarita M. ,   Irkutsk National Research Technical University
Published: November 2022

Abstract. In connection with the Decree of the RF Government No. 1431 dated September 15, 2020, and the approval of the action plan (roadmap) for the development of the construction industry in Rus-sia, the use of software systems for three-dimensional modelling in the design of residential and public buildings funded by federal and municipal funds has become a necessity. When designing engineer-ing systems for such buildings, the Revit software package allows the thermal performance of heating facilities to be calculated based on an information model in automatic mode. In this regard, a compara-tive assessment of automated and manual calculations performed in accordance with the regulatory documentation adopted in Russia is required in order to identify the possibility of their use for design-ing efficient heating systems. On the example of a one-story residential building located in the city of Irkutsk, the thermal performance of the heating system was calculated using both the Revit software package and according to the generally accepted methodology. A comparative analysis of the results showed the insufficient accuracy of automated calculations. Therefore, the use of automated calcula-tions can lead to the overestimated capital costs of construction and energy consumption of the build-ing. The reasons for this inaccuracy may be associated with a lack of attributive information about the families of windows and doors developed by manufacturers. As a result, the software package fails to perceive these families as part of the constructive component of the information model. However, the possibility of a system error in the Revit software package, which may distort further calculations, should not be ignored.
Empirical Quality Evaluation of Common Brands of Ceftriaxone Sodium Injection Marketed in the Northern Region of Nigeria
Authors:   Kano State Drug and Medical Consumable Supply Agency, Kano, Nigeria, Malami Dahiru Ibrahim , Aminu Nafiu ,   Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, Jatau Abubakar Ibrahim ,   School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia, Hassan Mohammed Al-Kassim ,   Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Bayero University, Kano, Nigeria, Ilyasu Salim ,   Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Bayero University, Kano, Nigeria, Daniel Abraham ,   School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia
Published: November 2022

Information related to the quality of ceftriaxone (CF) sold in northern Nigeria is limited. Therefore, we aimed to evaluate the quality of different brands of CF sodium injections marketed in Kano State of Nigeria. Thirteen different brands of CF sodium for injection (three samples per brand) were obtained from patent medicines vendors (PMVs), pharmacies and a government drug store in Kano State of Nigeria. The quality of these brands was assessed using physicochemical quality-control tests (colour, appearance, labelling, pH, weight uniformity and percentage of content). The results obtained from these tests were checked for compliance with the standards specified in British Pharmacopoeia 2009 (BP 2009) and the United States Pharmacopeia 2016 (USP 2016). All 13 (100%) brands were registered with the National Agency for Food and Drug Administration and Control (NAFDAC). The samples were brands imported from other countries and passed tests for colour and pH. However, 1 of the 13 samples did not pass the labelling inspection and only 4 (30.8%) brands were found to fulfil the requirements for physical appearance. Twelve (92.3%) of the 13 evaluated brands were found to have an acceptable percentage of content within a range of 95%–105% based on BP 2009 standards. The tested brands of CF sodium injection being marketed in Kano State of Nigeria were found to have variable compliance regarding the BP 2009 and USP 2016 specifications. Therefore, there is a need for relevant regulatory agencies to embark on more post-marketing surveillance to ensure the quality of medicines in Nigeria.
Therapeutic Profile of Glycyrrhiza glabra: A Ray of Hope in Treating COVID-19
Authors:   Department of Pharmaceutical Services, Murtala Muhammad Specialist Hospital, HMB Kano, Nigeria, SHEHU IBRAHIM AMINU , DATTA APARNA ,   Department Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, India
Published: November 2022

Glycyrrhiza glabra Linn (licorice) has been widely studied because of the possible ethnopharmacological benefit. It was among the essential Ayurvedic medicines studied for immunomodulatory, antiviral, antibacterial, antioxidant, hepato-protective activities. Nowadays, licorice’s root parts have been evaluated to contain numerous bioactive components responsible for the treatment of respiratory tract infections and influenza-like illnesses. Most importantly, several investigations have now assessed the multiple mechanisms by which these biomolecules could attack the essential proteins and enzymes responsible for SARS-CoV-2 cellular entry and interaction. Our findings gathered that the metabolites of Glycyrrhiza glabra could interfere with COVID-19 cellular entrance and replication by blocking all five key proteins and enzymes essential for the survival and attachment of the virus. In addition to their ability to neutralise, the inflammatory cytokines storm reaction following the COVID-19 viral infection. This review was designed to digest the potential pharmacological importance of Glycyrrhiza glabra and its likeness in combating the pandemic COVID-19.
Cross-Sectional Study on the Attitude and Perception of Healthcare Practitioners Towards Medication Errors in a Nigerian Tertiary Hospital
Authors:   Pharmacy Department, University College Hospital, Ibadan, Nigeria, Oladokun Bolanle Stephen , Oladokun Oladiran Boniface ,   Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Nigeria, Aje Akinniyi Akinbiyi ,   Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
Published: November 2022

This study was carried out to evaluate the attitude and perception of healthcare professionals towards medication errors. A cross-sectional study was carried out using a semi-structured questionnaire administered to nurses, pharmacists and physicians at the University College Hospital of Ibadan, Nigeria. Data were analysed with descriptive and inferential statistics. Most of the study participants, 444 (55.5%) and 472 (59.0%) had excellent attitudes and perceptions of medication errors, respectively. Most of the healthcare practitioners (89.1% nurses, 71.8% pharmacists and 66.7% physicians) disagreed with the statement that medication errors are unavoidable and are merely expected daily mistakes. It was observed that 35.5%, 37.6% and 66.7% of the nurses and pharmacists, and physicians, respectively, agreed with the statement that persons responsible for medication errors should be liable for legal actions. Suggestions made by the healthcare professionals on measures to prevent medication errors included recruitment of new staff to increase staff strength (32.8%), training on medication errors (21.4%) and legible handwriting of prescribers (9.4%). The prevalence of unreported medication errors by the study participants was 24.9%. Reasons for not reporting medication error committed included that it was trivial and had no adverse effect on the patient (32.3%), excess workload (26.9%) and fear of reprimand (17.7%). The healthcare professionals displayed excellent attitudes and perceptions of medication errors. An increase in staff strength and training on medication errors were major measures suggested by the study participants to prevent medication errors.
Molecular Docking, Drug-Likeness and SwissADME Evaluations of the Interactions of 2’-Substituted Triclosan Derivatives with Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase
Authors:   Department of Chemistry, Faculty of Physical Sciences, Ahmadu Bello University, Zaria, Nigeria, Ibrahim Zakari Ya’u , Uzairu Adamu ,   Department of Chemistry, Faculty of Physical Sciences, Ahmadu Bello University, Zaria, Nigeria, Shallangwa Gideon Adamu ,   Department of Chemistry, Faculty of Physical Sciences, Ahmadu Bello University, Zaria, Nigeria, Abechi Stephen Eyije ,   Department of Chemistry, Faculty of Physical Sciences, Ahmadu Bello University, Zaria, Nigeria, Isyaku Sulaiman ,   Department of Chemistry, Faculty of Physical Sciences, Ahmadu Bello University, Zaria, Nigeria
Published: November 2022

The orthodox process of investigating lead molecules is a lengthy and laborious one that in most cases leads to minimal success. Molecular docking analysis provides an alternative path to drug discovery through the interactions of two or more complexes. Molecular docking studies were performed on 12 theoretically designed derivatives of 2’-substituted triclosan against a Plasmodium falciparum (P. falciparum) enoyl-acyl carrier protein reductase (PfENR) protein target as well as predicting their drug-likeness and SwissADME properties. The docking studies were carried out using the Molegro Virtual Docker (MVD) where the molecular interactions between the ligands and the target protein were studied. The docking analysis revealed 5-(((5-chloro-2-(4-chloro-2-hydroxyphenoxy)benzyl)amino)methyl) benzofuran-6-ol (re-rank docking score = -145.497 kcal/mol) as the most stable derivative. The compounds were all found to completely concord with the Lipinski rule regulations, in addition to the molar refractivity as well as the number of rotatable bonds appearing within acceptable limits. All compounds except 2–5 and 7 show high gastrointestinal absorption, and are non-inhibitors of cytochrome P450; CYP1A2 and CYP2C19 except CYP2C9, lack BBB penetration, and only compounds 2–7 and 12 were found to inhibit permeabilityglycoprotein (P-gp) substrate. The findings suggest that some of the derivatives tend to increase the oral bioavailability of the substrate and most of them cannot be used in the treatment of cerebral malaria. These results may lead to future optimisation of the designed derivatives for improved antimalarial agents.
Drug Utilisation Evaluation of Human Albumin Solution in Tawau Hospital, Sabah, Malaysia
Authors:   Department of Pharmacy, Hospital Tawau, Sabah, Malaysia, Mazlan Nurashikin , Yee Connie Vun Sie ,   Department of Pharmacy, Hospital Tawau, Sabah, Malaysia, Mat Yusoff Alina ,   Department of Pharmacy, Hospital Tawau, Sabah, Malaysia, Baharudin Muhamad Fauzanudin ,   Department of Pharmacy, Hospital Tawau, Sabah, Malaysia, Catherine Ong Kim Yok ,   Department of Pharmacy, Hospital Tawau, Sabah, Malaysia, Krishnan Kohila ,   Department of Pharmacy, Hospital Tawau, Sabah, Malaysia, Limun Mohd Fairul ,   Gastroenterology Unit, Medical Department, Hospital Serdang, Selangor, Malaysia
Published: November 2022

Human albumin solution (HAS) which is available in government hospitals in Malaysia, mostly are supplied by the National Blood Centre, Ministry of Health (MOH) Malaysia. Due to the high usage of HAS, it is a strain to meet the demands nationwide. Moreover, HAS is very expensive. This study was a retrospective observational study evaluating drug utilisation of HAS in Hospital Tawau, Sabah. A name list of 61 patients who had received HAS between 6 months from 1 January to 30 June 2019 was sent for medical records tracing. Forty-eight prescriptions of HAS were evaluated and later categorised as ‘proven indications’ or ‘unproven indications’ with the aid of an internally prepared guideline. The result of this study indicates that 12 (25%) out of 48 prescriptions were for ‘unproven indications’. Possible wastage due to ‘unproven indications’ was 29 vials which were 20% of the total HAS usage in this study, estimated to cost RM7,804 (USD1,880). Major surgery with a serum albumin level of 20 g/L and above (55.2%), paracentesis with ascitic fluid removed of less than 5 L (24.1%) and hypoalbuminemia without justified comorbid or diagnosis (20.6%) being reasons for possible wastage of HAS in this study. The percentage of possible wastage of HAS reflected in this study was not as high as other published research done in other countries, mainly due to additional steps required for prescribing HAS in our facility (filling Blood Plasma Product Request Form) and also the need to obtain approval from the Director-General of MOH Malaysia if it was prescribed for other than the approved indications.
Analisis sitasi pada jurnal berkala arkeologi menggunakan aplikasi “Publish or Perish”
Authors: Saputro Bayu Indra
Published: November 2022

Purpose. This article explains how to determine the quality of a scientific journal by analyzing the level of citation in Berkala Arkeologi journal articles.Methodology. The method used is bibliometric analysis which aims to determine the distribution of citations in an article document in a journal. The data source of this research is Berkala Arkeologi articles for the period of 42 years between 1980 and 2022 which were downloaded using the Publish or Perish 7 application.Results and discussion. The most prolific authors in publishing articles in the journal Berkala Arkeologi are Indah Asikin and T.M Hari Lelono with 24 articles. While the article written by Ph. Subroto has the highest citation among other articles, namely 25 citations. The Journal of Archaeology also publishes articles in a timely manner.Conclusion. Journal Berkala Arkeologi has implemented the periodicity of articles published on time and applies open access. The most prolific authors in publishing articles in the journal Berkala Arkeologi are Indah Asikin and T.M Hari Lelono with 24 articles. While the article written by Ph. Subroto with the title Zonal Patterns of Archaeological Sites published in 1995 turned out to have the highest number of citations among other articles. Thus, the number of articles published by the author is inversely proportional to the number of citations. But this proves that the article still has an influence in the development of archaeology.
Depressão entre estudantes de Medicina no ano de 2022: um estudo comparativo entre o ensino tradicional e o ativo
Authors: Montenegro-Pires Julia Leite , Alves de Sousa Milena Nunes
Published: November 2022

Introdução: a depressão consiste é um transtorno mental recorrente e incapacitante, resultante da influência de fatores sociais, psicológicos e biológicos, dentre os cursos acadêmicos, têm-se o de Medicina com maior prevalência desta psicopatologia. Objetivo: comparar os índices de depressão entre acadêmicos de Medicina inseridos em instituições que adotam as metodologias ativas e tradicionais. Metodologia: pesquisa de campo, transversal, com abordagem quantitativa realizada por meio de formulário disponibilizado em redes sociais e aprovada pelo Comitê de Ética (no 5.210.194/2021). Para a coleta de dados, utilizou-se o Inventário de Beck, o qual foi aplicado a 138 estudantes. Os dados foram analisados mediante estatística descritiva simples e para inferir predição entre as variáveis, usou-se a regressão logística binária (método enter), U de Mann-Whitney para comparação entre grupos e cálculos de tamanho de efeito (r), além do Qui-quadrado de Pearson (2x4) para associações e cálculos de prevalência para cada grupo (p < 0,05). Resultados: a pesquisa mostrou uma média de idade foi de 23,55 ±3,96 e predomínio do sexo feminino (65,33%). Observou-se prevalência de depressão entre estudantes do oitavo período de medicina de 36,6%. Foi possível observar a metodologia do ensino e a depressão tiveram impacto estatisticamente significativo nos desejos suicidas. Ainda, que não foi possível encontrar diferenças estatisticamente significativas entre metodologias de ensino (metodologias ativas e metodologia tradicional) e depressão (U = 1633,000, z = -1,488, p < 0,13). Conclusão: os achados deste estudo reforçam a necessidade de novas pesquisas, especialmente comparativas entre ensino tradicional e ativo, uma vez que são escassas. Ademais, avaliar a saúde mental dos acadêmicos de medicina é fundamental, pois é preciso cuidar daquele que vai prover o cuidado.
Onicomatricoma: puntos clínicos claves de una enfermedad infrecuente
Authors: Osorio Calle Raquel , Mejía Posada María Isabel , Saldarriaga Santamaria Sara , Jiménez Calfat Guillermo , Ruíz Suárez Ana Cristina
Published: November 2022

Introducción: el onicomatricoma es un tumor fibroepitelial originado en la matriz ungular, es infrecuente y suele presentarse alrededor de la quinta y sexta década de la vida. Métodos: se presenta el caso de un paciente masculino de 57 años, sin antecedentes patológicos, quien consultó por una lesión no dolorosa en la uña del tercer dedo de la mano derecha. Al examen físico presentaba cromoniquia amarilla longitudinal, estrías blanquecinas y hemorragias en astilla. Se realizó onicectomía y matricectomía proximal y se envió el especimen resecado a estudio histopatológico. Resultados: el examen histopatológico reportó una lesión fibroepitelial, con invaginaciones del epitelio y ausencia de la capa granulosa. En el estroma se observaban células ondulantes y fusocelulares acompañadas de mastocitos. Se realizaron tinciones de inmunohistoquímica, confirmando el diagnóstico de onicomatricoma, variante micropapilifera. Conclusiones: debido a los múltiples diagnósticos diferenciales de esta condición, es importante para el dermatólogo familiarizarse con la clínica, hallazgos dermatoscópicos y manejo de esta entidad.
Attribution of changes in the water balance of a basin to land-use changes through combined modelling of basin hydrology and land-use dynamics
Authors: Gunacti Mert Can , Kandemir Fulya Aydin , Najar Mohamed , Kuzucu Aysegul , Uyar Meltem , Barbaros Filiz , Boyacioglu Hulya , Gul Gulay Onusluel , Gul Ali
Published: November 2022

Land use and land cover change (LULCC) is considered one of the major drivers of climate change, although climate change can also foster direct or indirect influences leading to LULCC. The objective of the presented study is to offer a strategic observation frame as the land use and land cover (LULC) transitions are grouped to define the cover flows (CFs). The Küçük Menderes River Basin (KMRB), which is located in the west of Turkey was examined as the case study. Through LULCC modelling via the employment of multi-layer perceptron (MLP), cellular automata (CA), and Markov Chain methods, future LULC maps were projected up to the horizon of 2050. Hydrologic responses of the basin to LULCC were determined by the developed hydrologic model, which is generated by the Soil and Water Assessment Tool (SWAT). The superimposed impacts of the examined effects of LULCC have been investigated by the CF types. This way, the individual impacts of the CFs have been assessed. In the case of the KMRB, projected annual runoffs for the year 2050 cover map represent a 9.06% reduction and the major responsible CF type for this reduction is the conversion from forest to non-irrigated agricultural land cover by 22.90%.
Support vector machine (SVM) approach to develop the discharge prediction model for triangular labyrinth weir
Authors: Mustafa Mohammad Danish , Mansoor Talib , Muzzammil Mohammad
Published: November 2022

Most of the studies on labyrinth weir were carried out in the laboratory, and regression models have been developed for discharge coefficient in terms of pertinent independent parameters. It is difficult to obtain an exact analytical solution to the head discharge relationship due to the existence of 3D flow. Consequently, various forms of soft computing techniques are used as an appropriate alternative to achieve greater accuracy in developing a discharge prediction model. In the present study, support vector regression (SVR) has, therefore, been implemented to develop a discharge coefficient prediction model for a triangular labyrinth (TL) weir using a sizeable amount of laboratory data available in the literature. An attempt has also been made to obtain a simple discharge coefficient equation using the same data based on the non-linear regression (NLR) approach for field application. A comparative study has been carried out to assess the accuracy of the discharge coefficient models obtained in the present study and those reported in the literature. Sensitivity analysis has been made to study the influence of individual parameters on the discharge coefficient. The accuracy of different discharge coefficient prediction models was also tested for the data of prototype labyrinth weir and appropriate models were recommended for the field application.
Enhanced electrochemical precipitation of phosphorus in wastewater by the addition of drifting Corbicula shells
Authors: Takabe Yugo , Uchida Rika , Yoneda Arisa
Published: November 2022

Phosphorus (P) is a finite and essential resource, and its linear movement from mines to waste streams may result in shortages. This has encouraged efforts to recover P from sewage systems for reuse. This study developed a new electrochemical P precipitation system for the subnatant of the sludge flotation thickening process, in which drifting Corbicula shells are added to provide a supply of calcium ions (Ca2+) to promote P precipitation. However, adding Corbicula shells to coexisting suspended solids (SS) and coagulant resulted in adsorption of the shells in the neutralized and hydrophobized floc clusters, which limited their electrochemical dissolution. Adding Corbicula shells after SS removal by flotation with electrochemically generated gases resulted in their successful electrochemical dissolution, which enhanced phosphate-P removal. Increasing the amount of Corbicula shells enhanced the phosphate-P removal to a point, after which further addition simply increased Ca2+. The consumption of H+ generated near the anode for the dissolution of Corbicula shells increased the pH of the bulk solution, which enabled P precipitation not only onto the cathode but also in the bulk solution. Analysis of chemical composition in the generated particles suggests that they can be used as a slow P-release fertilizer and soil conditioner.
Graduação de Enfermagem em tempos de pandemia da COVID-19: Implicações para formação profissional
Authors: Ferreira Rejane Eleuterio , Gonçalves Lilian  Maria da Costa , Santos Ana Luisa Rodrigues , Santos Rafaela Liz de Castro dos , Souza Daniella da Silva de
Published: November 2022

A pandemia causada pela COVID-19 resultou em um forte impacto socioeconômico, educacional e político em todo o mundo. A graduação de Enfermagem sofre, então, as consequências advindas desse contexto global atual, acarretando diversas implicações para a formação profissional. Sendo assim, o estudo terá como objetivo geral: Discutir sobre o processo de formação na graduação de Enfermagem em uma universidade pública durante o período da pandemia da COVID-19 sob a ótica de discentes, e como objetivos específicos: descrever as principais decisões que a universidade teve para garantir qualidade da formação no período de enfrentamento da COVID-19; descrever como os alunos de enfermagem vivenciaram a sua formação em plena pandemia; identificar quais foram as principais necessidades e desafios dos alunos durante esse período. Metodologia: Trata-se de um estudo descritivo e exploratório de abordagem qualitativa e sociopoética, que será realizado na Escola de Enfermagem Anna Nery da Universidade Federal do Rio de Janeiro, com alunos do curso de graduação em Enfermagem. A produção dos dados usará a técnica de análise documental, entrevista utilizando-se de questionário com perguntas aberta e fechada e grupo-pesquisador sociopoético. Os dados serão analisados por meio da análise de conteúdo de Bardin e as expressões artísticas do grupo-pesquisador serão analisadas conforme o estudo da sociopoética Viril/classificatório. A pesquisa foi aprovada no conselho de ética em pesquisa e respeitará os princípios da resolução 466/2012.
Palavras Chave: COVID-19; Educação em Enfermagem durante a pandemia; Implicações na formação em enfermagem; Impactos causados pela pandemia COVID-19 na Educação em Enfermagem.
Educação Permanente como estratégia educativa em Centros de Materiais e Esterilização: uma Revisão Integrativa
Authors: Pimentel Valéria Ornellas Luz , Cordeiro Benedito Carlos
Published: November 2022

O Centro de Material e esterilização (CME) é caracterizado como uma unidade de assistência indireta e de apoio técnico para o cuidado ao paciente. Objetivos: identificar e analisar estudos primários, sobre as práticas de trabalho dos profissionais de enfermagem que atuam nos Centros de Materiais e Esterilização, bem como identificar o perfil dos profissionais e suas percepções acerca da educação permanente. Método: Revisão integrativa, na qual foram utilizados artigos científicos publicados de 2011 a 2020, indexados nas bases de dados Literatura Latino-Americana e do Caribe em ciências da saúde (LILACS), Medical Literature Analisys and Retrietal System Online (Medline), Base de Dados de Enfermagem (BDENF), por meio da busca online na Biblioteca Virtual em Saúde (BVS), com os descritores “esterilização, centro de material e esterilização, educação continuada e educação permanente”. Resultados: Predominaram estudos que tiveram como objetivos analisar e compreender o processo de trabalho do enfermeiro no CME e traçar suas principais atribuições. Discussão: Embora os estudos tenham apontado a preocupação com a capacitação dos profissionais, ainda é possível identificar que os serviços de saúde apresentam dificuldades na seleção da equipe de enfermagem, o que dificulta oportunidades de ensino. O avanço tecnológico e o processamento de material inadequado aceleram a necessidade de adotar metodologias de ensino aplicáveis no cenário em questão. Considerações finais: Este estudo revela a importância de enfatizar a educação permanente como estratégia educativa, assim como aperfeiçoar as metodologias utilizadas atualmente.
Palavras-chave: Esterilização; Educação Continuada; Centro de Material e Esterilização.
A Study on the Reading Motivation of Korean Web Novel Users: Focusing on the theory of Use and Gratification
Authors:   The Korean Publishing Science Society, Kim Joo , Kim Sun Nam
Published: November 2022

The purpose of this study is double fold. One is to derive the types of reading motivation of web novel users based on the theory of use and gratification. The other one is to empirically investigate the relationship between their satisfaction and continuous use intention. For the research data were collected through a nine-day survey. 324 users who had read web novels from November 1 to November 8, 2021 were participated in the survey. From the analyses five types of motivations were found, including 'information', 'convenience', 'entertainment', 'relationship pursuit', and 'curious pursuit'. Among these motivational types, 'convenience' was the most influential one in determining the satisfaction of web novel users. This shows that convenience is the most important factor which web novel users pay attention to in reading web novels. It was also found that the user's satisfaction had a significant effect on the intention to continue the use of web novels. In other words, the more satisfied users were, the higher their intention to continue the use in the future.On the basis of this study suggests that marketing strategies should focus on the convenience-related motivation of web novel users. This marketing strategies are believed to be useful because the convenience-related motivation is likely to not only increase their satisfaction but also contribute to the intention of using them in the future.
The Association between External Training Load, Perceived Exertion and Total Quality Recovery in Sub-Elite Youth Football
Authors: Teixeira José E. , Forte Pedro , Ferraz Ricardo , Leal Miguel , Ribeiro Joana , Silva António J. , Barbosa Tiago M. , Monteiro António M.
Published: November 2022

Background:

Moderate to very large correlation between internal training load, external training load, and recovery status have been reported in elite youth football. However, little is known about subelite youth football training environments.

Objective:

The purpose of this study was to assess the association between training load and recovery status in young subelite football players.

Methods:

Twenty under-15, twenty under-17, and twenty under-19 players were monitored over a 6-week period during the first month of the 2019-2020 competitive season. The global positioning system technology (GPS) was used to collect external training load variables. The internal training load variables were monitored using the rating of perceived exertion (RPE) scale and session RPE (sRPE). The recovery status was assessed by the total quality recovery (TQR). A total of 18 training sessions and 324 observation cases were collected.

Results:

Small to moderate correlation between internal and external load was observed (r = -0.316 to 0.136, p < 0.05). Correlations between recovery status and external load were moderate for U15 (r = -0.326 to -0.240, p < 0.05), U17 (r = -0.316 to 0.136, p < 0.05) and U19 (r = -0.301 to 0.282, p < 0.05). The association between perceived exertion and external training load is only significant for U19 subelite football players.

Conclusion:

Current research suggested that subelite youth football players were more likely to have lower capacity to judge training exertion. Additionally, recovery status was positively correlated with acceleration and deceleration movements. This study provides a new overview about training load and recovery in subelite youth training environment. Future researche should examine the between- and within-individual nonlinearity across training load and recovery variations.
Antropoceno: um polissema a ser feito
Authors: Ribeiro Mendes João
Published: November 2022

O conceito de Antropoceno, desde a sua introdução em 2000, atraiu um número de publicações exponencialmente crescente. Todavia, mais de vinte anos passados, o seu significado permanece ainda relativamente aberto e submetido a densificação. Neste artigo, realiza-se uma reconstrução da carreira histórica da noção, mostrando que, durante a primeira década deste século, ela circulou e foi trabalhada sobretudo no domínio das Geociências, e, depois de então, tem vindo a ser explorada e enriquecida semanticamente no domínio das Ciências Sociais e das Humanidades. O objetivo é mostrar como é que se foi tornando num conceito-síntese e num conceito-alerta, cuja influência no pensamento planetário do século XXI é cada vez mais notória.