bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Key Points of Building Steel Structure Design
Authors: Liu Xiaohui
Published: August 2022

The quality of the steel structure is light, high strength, and has a strong integrity, so in the construction of the construction project is more and more widely used. Especially in the current social and economic development, the accelerated urbanization process, to promote the rapid development of the construction industry, people have put forward higher requirements for the quality of buildings. Therefore, in the construction of building steel structure, it is necessary to optimize the design, clarify the key points of steel structure design, strengthen the quality control, and promote the construction quality of the overall construction project. This paper mainly analyzes the importance, characteristics and key points of building steel structure design, aiming to further improve the level of building steel structure design, promote the high-quality development of China’s construction engineering, and provide people with more highquality, safe and reliable living conditions.
Modern linguistics
Authors: Shakirova Rezeda  Dilshatovna , Mustafina Ramilya Fanisovna , Belyakovsky Boris Yuryevich , Kepa Yuri Nikitovich , Klimakina Elena Alexandrowna
Published: August 2022

The article examines a cognitive script of the transmission of reliable information on the example of German modal words (MW). To achieve the goal of the study, a cognitive method was used, the main postulate of which is considered to be the active interaction of the structure of consciousness (mental representations) and the structure of the language. It is primarily about the representation of mental processes and their results in the language. The emergence of the cognitive method is associated with the attention of linguists, first of all, to the person himself or herself and his or her consciousness. With regard to the concept of reliability, we should note our understanding of reliability as an indication of the qualification of information as corresponding to reality, which does not cause doubts among members of a certain community.
Development of intercultural competence in foreign language classes at the medical university
Authors: Olshvang Olga
Published: August 2022

This article describes the experience of using the project method in foreign language classes at the medical university. Using the example of the implementation of the project "Medical Education and Healthcare Abroad", the development of intercultural competence and its role in teaching a foreign language are examined. The features of the development of intercultural competence at the non-linguistic university are noted. The participation of an expert (teacher of the Department of Public Health and Healthcare) gives this project an interdisciplinary character, and also increases students’ motivation. This project allows to work on four aspects described in the Common European Framework of Reference for Languages (CEFR): listening, reading, writing and speaking. The use of self-assessment and peer assessment helps to develop critical thinking and allows students to improve their own projects. This project can be implemented in groups where students master a foreign language at different levels.
Modern linguistics
Authors: Kharaeva Larisa Khanbievna , Kardanov Musadin Latifovich , Ezaova Madina Yurievna , Khezheva Lena Khabilovna , Shugusheva Juleta Khabasovna
Published: August 2022

Artistic discourse is understood as a communication system, which is a synthesis of specific linguistic forms, information about reality, reflected in a text that is distinguished by its pragmatic content. The pragmatic level of artistic discourse is represented by an individual set of characteristic linguistic means. The object of the research is the linguistic units denoting color, functioning in the language, mythopoetics, paremias, and literature in the Adyghe language. The subject of the research is the peculiarities of the manifestation and functioning of color painting in the Adyghe language and Adyghe literature, as well as the identification of the specifics of the coloristic embodiment of images in the works of Adyghe authors. The material of the research is based on the linguistic representations of color designations that form the "black-white-red" triad.
Dreamlike and narrative nature of screen texts
Authors: Grigoryev Sergey , Saenko Natalya , Volkova Polina , Goncharenko Natalya
Published: August 2022

It is argued that the screen narrative is the most effective means of representing dreaming, the temptation of voyeurism. A gradual historical movement of a screen narration from literary work with plots related to dreaming and to oneiric as the poetics of a future film is noted in the paper. The feature drama of the French director François Ozon "In the House" (2012) is analyzed. The postmodern characteristics of poetics and semiotics of the film are considered. A model "the narrator and the listener" is proposed as a semiotic interpretation of the film.
Effectiveness of foreign language teaching techniques
Authors: Rets Nataliya , Pivneva Svetlana , Pasiukova Olga , Zolotareva Svetlana , Abalyan Zhanna , Khutova Elmira
Published: August 2022

The study analyzes the problem of providing corrective feedback in studying a foreign language at the university as one of the types of feedback between a teacher and a student. The article regards feedback as a way of correcting students’ mistakes in executing control. The paper offers a characteristic of written feedback, identifies its various types and subtypes in terms of their specific characteristics and efficiency of use. Various approaches to the correction of students’ mistakes in writing and speech are analyzed. Particular attention is devoted to the conditions of giving effective feedback. The conducted experimental study of the effectiveness of different types of written corrective feedback between a teacher and a student in the process of foreign language learning concludes that indirect written corrective feedback proves more effective since indirect feedback requires greater participation of the students and their active involvement in the learning process.
EFFECT OF RUBBER PRODUCTION, DOLLAR EXCHANGE RATE AND INFLATION ON RUBBER EXPORTS IN INDONESIA
Authors: Fatahillah Fatahillah , Andriyani Devi , Rahmah Mutia , Syafira Syarifah
Published: August 2022

This study was conducted in Indonesia and aimed to examine the effect of rubber production, the dollar exchange rate, and inflation on rubber exports. The data analysis method used was multiple linear regression. The results showed that rubber production and inflation positively and significantly influenced rubber exports, while the dollar exchange rate negatively and significantly influenced rubber exports. Simultaneously, rubber production, the dollar exchange rate, and inflation positively and significantly influenced rubber exports in Indonesia, and the magnitude (R^2) of the effect of the amount of production, dollar exchange rate, and inflation on rubber exports was 0.5979 (59.79%)
THE EFFECT OF GENERAL ALLOCATION FUNDS AND FUEL SUBSIDIES ON CAPITAL EXPENDITURES IN INDONESIA
Authors: Qwanthala Yuanda Shinta , Husen Ratna , Murtala Murtala
Published: August 2022

The purpose of this study is to examine the impact of general allocation funds and fuel subsidies on capital expenditures in Indonesia. From 1990 through 2020, this analysis makes use of secondary data from the Indonesian Ministry of Finance and the World Bank. The data was examined using the eviews 10 analytic tool and the multiple linear regression approach. According to the findings of the study, the general allocation fund has a favorable and considerable impact on capital spending in Indonesia. Meanwhile, fuel subsidies have a considerable negative impact on capital expenditures in Indonesia. The size of the effect of general allocation funds and fuel subsidies on capital expenditures is 95,66%, whereas the influence of other general allocation funds outside of this model is 4,34%. It is advised that government subsidies be used as efficiently as possible in order to promote wellbeing.
Impacto del modelo de salud y la inclusión de las tecnologías en el PBS. Retos en dermatología
Authors: Castro-Ayarza Juan Raúl
Published: August 2022

A partir del año 2022, el Ministerio de Salud de Colombia realizará un cambio para actualizar y modificar los medicamentos y las tecnologías en salud que deben ser incluidos en la unidad de pago por capitación, mediante las resoluciones 2273 y 2292 de 2021, siendo una de las modificaciones más ambiciosas llevadas a cabo en los últimos años. Esto significa que de 459 principios activos pasaron a incluir 1059, lo que abre la utilización de una amplia gama de fármacos.
Relación médico-equipo de salud
Authors: Maya José María
Published: August 2022

Un médico especialista que labora en una institución de salud es llamado para evaluar a un paciente que tiene una lesión en el grueso artejo derecho. El médico evalúa al paciente y diagnostica una gangrena seca sobreagregada a una diabetes mellitus tipo 2 de 20 años de evolución. Informa a la familia del paciente y decide amputar el dedo con el fin de evitar las complicaciones infecciosas del proceso.
Una enfermera profesional del piso a cargo del paciente, al evidenciar en la programación de cirugía que el paciente será intervenido quirúrgicamente, lo visita y en la conversación se da cuenta de que este no está enterado de su diagnóstico ni de la cirugía que se le practicará. Llama al médico tratante y le pregunta la razón por la cual el paciente no está enterado de su diagnóstico ni de la cirugía. El médico le informa que su familia ya sabe y ratifica que intervendrá quirúrgicamente al paciente. Además, le reclama a la enfermera por cuestionarle el no haber explicado al paciente claramente su situación y obtenido su consentimiento para la cirugía. La enfermera defiende el derecho del paciente a conocer su situación y tomar una decisión autónoma al respecto e insiste que se hable con él. El médico se enoja con la enfermera, le manifiesta que él es quien toma las decisiones en el equipo de salud y que su labor es obedecer las órdenes médicas y no interferir con su actuación. Como la enfermera ratifica el derecho del paciente, el médico le ordena no insistir, le prohíbe informarle al paciente su situación y la acusa de comportamiento rebelde, que desconoce su estatus profesional y rol en el equipo de salud.
Se analiza el caso desde la perspectiva de los principios éticos y de la concepción actual de equipo de salud.
Reporte de dos casos infrecuentes de urticaria inducible en niños y un caso de urticaria por presión en mujer adulta durante la actividad sexual
Authors: Crespo Nardey , Santamaria Luís , Sánchez Andres , Sánchez Jorge
Published: August 2022

La urticaria crónica es una enfermedad bien definida en pacientes adultos; sin embargo, los datos son limitados en población pediátrica y en lo referente a la urticaria inducible en general. Esto lleva a retrasos en el diagnóstico y el tratamiento de la enfermedad, lo que genera grandes alteraciones en la calidad de vida de los pacientes. Se presentan tres casos poco usuales: uno de urticaria acuagenica, otro de urticaria colinérgica en niños, y uno de urticaria por presión durante la actividad sexual en una mujer adulta. Es importante la documentación de casos que describan el cuadro de presentación de las urticarias crónicas inducibles para establecer un mejor abordaje.
Dupilumab: mejoría dramática en una paciente con dermatitis atópica grave. A propósito de un caso
Authors: Arango Valentina , Garavito Ana María , Tamayo Liliana María
Published: August 2022

Se presenta el caso de una mujer de 25 años con diagnóstico de dermatitis atópica grave desde los 6 meses de vida, variedad eritemato descamativa, con compromiso de la superficie corporal mayor al 90 % y cuadros recurrentes, graves y de difícil control, resistentes a esteroides sistémicos e inmunosupresores. Se documentó mutación de la filagrina. Además, desarrolló depresión mayor, con tres intentos de suicidio. Teniendo en cuenta la refractariedad al tratamiento, las comorbilidades asociadas y la disminución de la calidad de vida, se decidió iniciar manejo con dupilumab. Con la cuarta dosis del medicamento hubo una mejoría dramática evaluada mediante índices estandarizados de gravedad (EASI, SCORAD, POEM, DLQI) para la enfermedad. La paciente logró el control de la enfermedad desde el inicio de la administración del medicamento, con lo que se pudo desmontar rápidamente los esteroides, e incluso presentó mejoría paulatina de su depresión, con desmonte del tratamiento antidepresivo.
Úlcera de Lipschütz
Authors: Orozco-Sebá Beatriz , Marchán-Cárdenas Juan Camilo , Meléndez Esperanza , Montagut Alonso Joseph
Published: August 2022

La úlcera de Lipschütz es una entidad de origen indeterminado, caracterizada por la aparición aguda de una úlcera vulvar, generalmente única, de gran tamaño y con bordes bien definidos, en una mujer adolescente o joven sin vida sexual. Su diagnóstico suele ser un reto para el profesional de salud, ya que es una enfermedad rara y poco reportada. Se diagnostica al descartar otras causas más comunes de úlceras vulvares: venéreas, sistémicas no infecciosas, medicamentosas, traumáticas o tumorales.
Relación médico-equipo de salud. Parte 2
Authors: Maya José María
Published: August 2022

Podríamos definir a un equipo de salud como un grupo multidisciplinario que se conforma con profesionales y personal técnico de distintas disciplinas, los cuales realizan diferentes actividades con un objetivo común, que es el de proveer en cualquier ámbito una atención de salud integral a los pacientes y sus familias. Cada miembro del equipo de salud posee diferentes habilidades, por lo que se espera que cada uno desempeñe el papel que le corresponda. En el equipo debe haber un coordinador o líder que utilice canales adecuados de comunicación que favorezcan el trabajo conjunto y eficiente en el cual cada miembro debe contribuir con sus conocimientos específicos y asumir sus responsabilidades.
COVID-19 in Patients with Psoriatic Arthritis
Authors: Smiyan Svitlana , Bilukha Anastasya , Koshak Bohdan , Hrymalyuk Oleh , Smiyan Viktoria
Published: August 2022

The COVID-19 pandemic has a negative impact on all aspects of human life and can lead to the exacerbation of chronic diseases. At the same time, it is known that a higher risk of infection and a more severe course of coronavirus infection is found in the elderly, as well as in people with serious comorbidities.
Psoriatic arthritis (PsA) is a type of inflammatory arthritis that is often diagnosed in patients with psoriasis. Specific treatment of patients with chronic inflammatory joint disease include nonsteroidal anti-inflammatory drugs, glucocorticosteroids, disease-modifying antirheumatic drugs, new biological agents, including monoclonal antibodies to IL-6, IL-1, TNF-a, target disease modifying drugs. Medications used for PsA treatment can potentially have both negative and positive effects on the course of COVID-19.
The objective: to analyze the features of COVID-19 in patients with PsA and to study the comorbid pathology after coronavirus infection.
Materials and methods. The study involved 174 people with a verified diagnosis of PsA. Patients were divided into two groups. Group I included 112 (64.4%) persons who had COVID-19, and group II - 62 (35.6%) who had not had coronavirus infection at the time of first examination.
Patients in group I significantly differed from group II in age (p <0.001) and duration of PsA (p <0.001), showed a significantly higher degree of psoriatic skin lesions and activity of the underlying disease (p = 0.001) compared to patients from group II. The participants of the study underwent examination characterize the course of the psoriatic disease and skin lesions and risk of cardiovascular disease.
Results. To date, there are no clear scientific data that reveal the specific features of COVID-19 infection and the effect of antirheumatic therapy on the development of dangerous complications associated with coronavirus infection in patients with PsA.
The analysis of comorbid pathology has found cardiovascular pathology in 67 (59.8%) of patients, including arterial hypertension – in 58 (51.8%) people, metabolic syndrome – in 34 (30.4%), diseases of the digestive system – in 32 (28.6%) and respiratory system – in 24 (21.4%) of persons.
Conclusions. Patients with higher activity and duration of the PsA were significantly more likely to get COVID-19 and demonstrated higher total cardiovascular risk for the next 10 years.
Further research is needed to study the impact of specific basic rheumatological drugs on the outcomes of COVID-19 and to analyze the broader effects of the pandemic on the course of psoriatic arthritis.
Diagnosis and Treatment of Primary Hypothyroidism in Primary Care
Authors: Protsiuk Olha
Published: August 2022

Decreased thyroid function occurs among 0,2–1% of men and 1,4–5% of women in the general population, and among people over 60 years among 2,5% of men and 6% of women.
Hypothyroidism in 95% of cases is caused by thyroid disfunction (primary hypothyroidism), only 5% of cases are central hypothyroidism, associated with dysfunction of the pituitary gland (insufficient production of thyroid-stimulating hormone) and hypothalamus (impaired thyroliberin synthesis).
Nonspecific clinical manifestations of hypothyroidism are the reason for examining the patient for thyroid hormone levels in primary care.
Primary hypothyroidism screening is a common clinical situation in the general practitioner`s practice. According to Guideline 00514. Hypothyroidism of the Finnish Medical Research Society Duodecim Medical Publications Ltd, the use of which is approved by the Order of the Ministry of Health of Ukraine № 1422 of December 29, 2016, diagnosis of hypothyroidism and treatment of primary hypothyroidism are the tasks of primary care professionals.
Decreased thyroid function may have subclinical and manifest forms, which are detected in the analysis of the results of thyroid hormones and clinical signs of the disease, require different treatment approaches. There are the differences in the use of levothyroxine replacement therapy in patients of different ages and depending on the causes of hypothyroidism.
Patients under 55 years old are prescribed levothyroxine sodium in a daily dose of 1,6–1,8 μg/kg body weight. In patients over 55 years old, the daily requirement of levothyroxine sodium is calculated at 0,9 μg/kg body weight, taking into account existing cardiovascular disease. If patients are obese, the calculation is made on the «ideal» weight.
The calculation of the dose and rules of levothyroxine sodium prescription in primary care are presented on the example of four clinical cases. The algorithm for control levothyroxine replacement therapy in patients with primary hypothyroidism is also presented.
Heart Involvement in Diabetes mellitus Patients
Authors: Shkala Lyubov
Published: August 2022

Diabetes mellitus (DM) is one of the most significant medical and social health problems worldwide. The main cause of death in patients with DM is cardiovascular diseases, which leads to the significant decrease in quality of life and life expectancy.
The aim of this literature review is analyze of the frequency, mechanisms and manifestations of heart disease in diabetes patients.
A significant amount of the modern researches is devoted to the diagnosis and treatment of the diabetes complications, including diabetic cardiomyopathy (DC). According to many authors, heart disease in diabetes is associated with the formation of DC, comorbid coronary heart disease and arterial hypertension. DC occurs in 16.8–54% of patients with diabetes and is an independent factor which increases the death risk by 50–60%.
Numerous scientific studies have been devoted to the diagnosis and treatment of DC, emphasizing that in order to reduce cardiovascular disease and mortality in patients with diabetes, it is necessary, above all, to achieve glycemic control. Diabetic history, age, comorbidities, atherosclerotic lesions, smoking, overweight or obesity also play an important role.
The main aspects of the development and impact of diabetes on the health and life of patients are the untimely diagnosis of this disease, its multifactorial pathogenesis, progressive course and severity of complications. Due to development of the early complications and disability, studies of morphofunctional changes in the myocardium in diabetes are extremely relevant, as cardiomyopathy may increase the risk of myocardial infarction and heart failure.
The rapid increase in the number of patients with diabetes, many of whom die from cardiovascular complications, makes the problem of diabetic heart disease one of the most pressing health problems. Treatment of these patients should include correction of carbohydrate metabolism, control of blood lipid composition, decrease in myocardial ischemia, correction of the myocardial metabolism and the risk of heart failure.
ХАРАКТЕРИСТИКА СКЛАДУ ЖИРНИХ КИСЛОТ У ПЛАЗМІ КРОВІ У ХВОРИХ НА ІНФІЛЬТРАТИВНИЙ ТУБЕРКУЛЬОЗ ЛЕГЕНЬ
Authors: Пикас Ольга
Published: August 2022

Мета дослідження – вивчити та оцінити склад жирних кислот (ЖК) ліпідів у плазмі крові у хворих на інфільтративний туберкульоз легень і визначити їх роль у розвитку хвороби. Методи. Склад жирних кислот визначали біохімічним методом на газорідинному хромат
ПОШИРЕНІСТЬ КАРІЄСУ СЕРЕД 6-15 РІЧНИХ ДІТЕЙ ІЗ ЗАХВОРЮВАННЯМИ ШЛУНКОВО-КИШКОВОГО ТРАКТУ
Authors: Лабій Юрій , Петрунів Володимир , Пясецька Людмила , Рожко Ольга , Рожко Віталій
Published: August 2022

В статті розглядаються результати вивчення поширеності та інтенсивності карієсу зубів у дітей віком 6-15 рр. із супутніми захворюваннями шлунково-кишкового тракту. Тривалий перебіг хронічних захворювань травної системи та часті загострення призводять до
ІМІТАЦІЙНЕ МОДЕЛЮВАННЯ РОБОТИ ПЕРЕВАНТАЖУВАЛЬНОГО КОМПЛЕКСУ «КРАНИ–ПАНЕЛЕВОЗИ»
Authors: Дехтярук Микола
Published: August 2022

Стаття присвячена сучасним комп'ютерним інформаційним технологіям. Розглянуто систему імітаційного моделювання GPSS World, з метою моделювання роботи перевантажувального комплексу “Крани-панелевози”. Розроблено імітаційну модель перевантажувального компле
ФОРМУВАННЯ КОМПЕТЕНТНОСТЕЙ У ЗДОБУВАЧІВ СТУПЕНЯ «БАКАЛАВР» ІНОЗЕМНОГО ПОХОДЖЕННЯ ПРИ ДИСТАНЦІЙНОМУ НАВЧАННІ З ДИСЦИПЛІНИ «БАЗИ ДАНИХ»
Authors: Пахомова Вікторія
Published: August 2022

Запропонована методика «ForeignDistLearnDB» щодо формування компетентностей здобувачів іноземного походження ступеня «бакалавр» спеціальностей «Комп’ютерна інженерія» при дистанційному навчанні з дисципліни «Бази даних», що складається із наступних етапів
ВИКОРИСТАННЯ ВИШНЕВО-БУРЯКОВОГО ПЮРЕ-НАПІВФАБРИКАТУ В ТЕХНОЛОГІЇ ЗАМОРОЖЕНИХ ДЕСЕРТІВ ДЛЯ ЗАКЛАДІВ РЕСТОРАННОГО ГОСПОДАРСТВА
Authors: Ущаповський Артем
Published: August 2022

В роботі обґрунтовано перспективи виробництва замороженого десерту «Насолода» на основі вишнево-бурякового пюре-напівфабрикату для закладів ресторанного господарства.На основі аналізу літературних джерел та власних досліджень розроблено рецептуру та техн
РОЗВИТОК ФОНДОВИХ БІРЖ В УКРАЇНІ ТА ПОРІВНЯЛЬНИЙ АНАЛІЗ НА ОСНОВІ СВІТОВОГО ДОСВІДУ
Authors: Смагло Ольга
Published: August 2022

Досліджено динаміку та структуру бірж України. Розглянуто обсяг та структуру первинного та вторинного ринку цінних паперів України, а також структуру торгів фондового ринку. Проведено порівняння обсягів торгів Українського фондового ринку з обсягами торг
АНАЛІЗ ТА ХАРАКТЕРИСТИКА ВНУТРІШНЬОГО ФІНАНСОВОГО РИНКУ УКРАЇНИ
Authors: Гатаулліна Ельміра
Published: August 2022

Внутрішній і зовнішній фінансові ринки, які входять до складу світового фінансового ринку, забезпечують вільне пересування капіталів у світовому масштабі, виступають важливим чинником функціонування всієї світової економіки. Важливу роль у функціонуванн
РОЛЬ СВІТОВОЇ ПАНДЕМІЇ У СТАНОВЛЕННІ ЦИФРОВОЇ ЕКОНОМІКИ ЯК МАЙБУТНЬОГО ТЕХНОЛОГІЧНОГО ПРОГРЕСУ
Authors: Жувагина Ирина
Published: August 2022

У науковій статті визначено роль цифрової економіки як основи майбутнього технологічного прориву. На основі представленних даних світових бірж, проаналізовано ріст долі цифрової економіки ВВП країн G20. Досліджено рейтинги найдорожчих компаній сучасності
LEXICAL AND GRAMMATICAL PECULIARITIES OF SCIENTIFIC-TECHNICAL TEXTS: CURRENT TRENDS
Authors: Ігнатюк Ольга
Published: August 2022

The science of translation and translation theory, or translation studies, is one of the youngest sciences of linguistics. There is an ever-increasing need for communication in fields such as science, culture, trade, etc. in the world. In most cases, this
ОЦІНКА ЕФЕКТИВНОСТІ ВИКОРИСТАННЯ МАРКЕТИНГОВОГО ПОТЕНЦІАЛУ ПІДПРИЄМСТВА
Authors: Поліщук Ірина , Довгань Юрій
Published: August 2022

В дослідженні розглядається питання оцінки ефективності використання маркетингового потенціалу підприємства. Авторами представлено основні принципи оцінки маркетингового потенціалу, представлено алгоритм традиційного методу оцінювання та визначено головні
PECULIARITIES OF USING DISTANCE LEARNING METHODS IN TRAINING OF JUNIOR BACHELORS
Authors: Кропельницька Юлія , Велика Алла , Школьна Н.О.
Published: August 2022

The modern rhythm of society development requires quality mass education, which everybody can gain conveniently. Moreover, as the population on Earth has been increasing, the probability of developing epidemics, various military conflicts, etc., is growin
ДО ПРОБЛЕМИ КОМПЕТЕНТНІСНО-СПРЯМОВАНОГО НАВЧАННЯ МАТЕМАТИКИ УЧНІВ ІЗ ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ
Authors: Дмитриева Ирина , Одинченко Лариса
Published: August 2022

У статті розглянуто сучасні підходи до навчання математики учнів із особливими освітніми потребами. Висвітлено особливості нейродинаміки вищої нервової діяльності та пізнавальної сфери дітей із інтелектуальними порушеннями, що викликають значні труднощі з
РОЗВИТОК ДИСТАНЦІЙНОГО НАВЧАННЯ ЯК УМОВА ФОРМУВАННЯ ОСВІЧЕНОЇ ОСОБИСТОСТІ
Authors: Мартинюк Л. , Мартинюк В.В.
Published: August 2022

Сутність поняття дистанційного навчання Характеристика технологічних моделей дистанційного навчання Головні цілі та завдання дистанційного навчання
Okul Müdürlerinin Kindarlık Davranışlarının Öğretmenlerin Örgütsel Sinizm Düzeylerine Etkisi
Authors: ASLAN Hüseyin
Published: August 2022

Bu araştırma, okul müdürlerinin kindarlık davranışlarının öğretmenlerin örgütsel düzeylerine etkisini ortaya çıkarmak için yapılmıştır. Araştırma nicel araştırma yöntemlerinden ilişkisel tarama deseninde yapılmıştır. Çalışmanın evrenini, 2021-2022 eğitim öğretim yılında Samsun merkez ilçelerinde bulunan ilkokul, ortaokul ve liselerde görev yapan 10376 öğretmen oluşturmaktadır. Çalışmanın örneklemini ise basit seçkisiz örnekleme yöntemiyle seçilen 371 öğretmen oluşturmaktadır. Veri toplamak amacıyla kişisel bilgi anketi, Elma’nın (2019) “Yönetsel Kindarlık Ölçeği” ve Kalagan (2009) tarafından Türkçe geçerlik ve güvenirlilik çalışması yapılmış olan on üç maddelik “Örgütsel Sinizim Ölçeği” kullanılmıştır. Bu çalışmanın istatistik analizleri SPSS programı ile yapılmıştır.

Verilerin analizinde frekans, yüzdelik dağılım, aritmetik ortalama, standart sapma, Kolmogorov Smirnov Testi, Scheffe Testi, t Testi, tek yönlü varyans analizi ANOVA, Pearson çarpım-moment korelasyon katsayısı ve araştırmanın yordama amacını sınamak üzere de basit doğrusal regresyon analizi işlemleri gerçekleştirilmiştir. Yönetsel Kindarlık Ölçeği’nin çalışma grubuna uygulanması sonucunda, öğretmenler okul yöneticilerini “düşük düzeyde” kindarlık davranışı sergilediklerini belirtmişlerdir. Öğretmenlerin okul yöneticilerini yönetsel kindarlık bulma düzeyleri; cinsiyet ve medeni durum değişkenlerine göre anlamlı farklılık göstermiştir. Mesleki kıdem, branş ve okul türü değişkenlerine göre, araştırmaya katılan öğretmenlerinin algılarına göre bir farklılık çıkmamıştır. Örgütsel Sinizim Ölçeği’nin çalışma grubuna uygulanması sonucunda, çalışma grubunu oluşturan öğretmenlerin örgütsel sinizim algıları “düşük” düzeyde çıkmıştır. Öğretmenlerin sinizim düzeyleri demografik değişkenlere göre anlamlı farklılık göstermemiştir. Araştırma sonucunda öğretmenlerin algılarına göre; yönetsel kindarlık ve örgütsel sinizm ile yönetsel kindarlık ve örgütsel sinizmin alt boyutları arasında istatistiksel olarak pozitif yönde ve orta düzeyde bir ilişki olduğu ve okul yönetiminin yönetsel kindarlık düzeyinin öğretmenlerin örgütsel sinizim algılarının pozitif yönde orta düzeyde anlamlı bir yordayıcısı olduğu görülmektedir.
Türkiye’de Cumhuriyet Dönemi Tarih Ders Kitaplarında Değişim ve Sürekliliğin İzini Sürmek: İttihat ve Terakki Cemiyeti Örneği
Authors: TURAN Refik
Published: August 2022

Genel kabul gören yaklaşıma göre 1889 yılında İstanbul’da bir grup Askeri Tıbbiye Mektebi öğrencisi tarafından gizli bir cemiyet olarak kurulan İttihat ve Terakki Cemiyeti Osmanlı Devleti’nin son on yılında gelişen olaylara damgasını vurmuştur. Cemiyet, ayrıca Millî Mücadele’nin örgütlenmesinde rol oynadığı gibi Cumhuriyet Dönemi’nde kısa bir süre de olsa iç siyasetin önemli bir figürü olmuştur. Türkiye’de Cumhuriyet Dönemi’nde liselerde okutulan tarih ders kitaplarında İttihat ve Terakki Cemiyeti ve ittihatçılara yaklaşımda meydana gelen değişimi ortaya koymayı amaçlayan tarama modelindeki bu araştırmada doküman incelemesi yönteminden yararlanılmıştır. Araştırmada temel materyal olarak Türkiye’deki liselerde 1931 yılı ile 2020 yılı arasında okutulan Tarih ve Türkiye Cumhuriyeti Tarihi (ve Türkiye Cumhuriyeti İnkılap Tarihi ve Atatürkçülük) ders kitaplarından yararlanılmıştır. Bu çerçevede araştırma, araştırma dönemini temsil ettiği düşünülen 20 ders kitabından oluşturulan bir örneklem üzerinde gerçekleştirilmiştir. Araştırmada elde edilen veriler nitel veri analiz tekniği olan betimsel analiz ile analiz edilmiş, ulaşılan bulgular oluşturulan kategoriler altında ele alınarak değerlendirilmiştir. Araştırma sonucunda Cumhuriyet Dönemi’nde İttihat ve Terakki Cemiyeti ile ilgili konuların çerçevesi ve yaklaşım tarzının 1931 yılında yayınlanan Tarih ders kitaplarında belirlendiği, dönemin iç siyasi gelişmelerinin bir yansıması olarak bu ders kitaplarında İttihat ve Terakki Cemiyetine karşı olumsuz yaklaşımın günümüze doğru yaklaştıkça giderek zayıfladığı ve konuların çeşitlendiği anlaşılmaktadır. Genel olarak 1931 ders kitaplarında hissedilen Cumhuriyetçi kadro-İttihatçı karşıtlığının 2000’li yıllara yaklaştıkça yerini belli ölçüde Osmanlı-İttihatçı karşıtlığına bıraktığını söylemek mümkündür.
Biological Evaluation of Maytansinoid-Based Site-Specific Antibody-Drug Conjugate Produced by Fully Chemical Conjugation Approach: AJICAP®
Authors: Seki Takuya , Yamada Kei , Ooba Yuri , Fujii Tomohiro , Narita Takahiro , Nakayama Akira , Kitahara Yoshiro , Mendelsohn Brian A. , Matsuda Yutaka , Okuzumi Tatsuya
Published: August 2022

Background: Trastuzumab-emtansine (T-DM1, commercial name: Kadcyla) is well-known antibody-drug conjugate (ADC) and was first approved for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. This molecular format consisting of trastuzumab and maytansinoid payload (emtansine) is very simple, however, T-DM1 has wide heterogeneity due to non-specific conjugation, lowering its therapeutic index (TI). Methods: To overcome this issue during the chemical modification of the random conjugation approach to generate T-DM1, we developed a novel chemical conjugation technology termed “AJICAP®” for modification of antibodies in site-specific manner by IgG Fc-affinity peptide based reagents. Results: In this study, we compared site-specific maytansinoid-based ADCs synthesized by AJICAP and T-DM1 in rat safety studies. The results indicated an increase in the maximum tolerated dose, demonstrating an expansion of the AJICAP-ADC therapeutic index compared with that of commercially available T-DM1. Gram scale preparation of this AJICAP-ADC and the initial stability study are also described. Conclusions: Trastuzumab-AJICAP-maytansinoid produced by this unique chemical conjugation methodology showed higher stability and tolerability than commercially available T-DM1.
More Attention on Segments Remote from the Primary Spinal Cord Lesion Site
Authors: Chelyshev Yuri
Published: August 2022

Recent findings from multimodal imaging studies point to macrostructural pathological changes in areas significantly distant from the epicenter of spinal cord injury, both in the spinal cord and in the brain. Studies are being performed to determine cellular and molecular mechanisms of these shifts, which are currently poorly understood. Research has demonstrated that the pathological process in the remote area is multifaceted. This process involves astrocytes and microglia, which contribute to the degeneration of nerve fibers passing from and through the immediate impact area, as well as participate in reciprocal activation. As a result, there is accompanying synaptic loss in areas remote to the spinal cord injury location. Reactive astrocytes produce chondroitin sulfate proteoglycans that inhibit axon growth and damage cells. However, neuronal death in the remote area remains controversial. The area of primary injury is the source of numerous neurotoxic molecules that release into the cerebrospinal fluid. It is assumed that these molecules, primarily matrix metalloproteinases, disrupt the blood-spinal cord barrier, which leads to tissue infiltration by macrophage precursors in the remote area. Activated macrophages secrete pro-inflammatory cytokines and matrix metalloproteinases, which, in turn, induce astrocytes and microglia towards a pro-inflammatory phenotype. In addition, reactive microglia, together with astrocytes, secrete numerous pro-inflammatory and neurotoxic molecules that activate inflammatory signaling pathways, consequently exacerbating synaptic depletion and neurological deterioration. It appears likely that the interplay between chronic inflammation and neurodegeneration is a pivotal characteristic of the pathological process in the spinal cord areas distant from the epicenter of the lesion. Pathological changes in the distant areas should be the object of research as potential therapeutic targets.
Dynamics of Acute Liver Injury in Experimental Models of Hepatotoxicity in the Context of Their Implementation in Preclinical Studies on Stem Cell Therapy
Authors: Czekaj Piotr , Król Mateusz , Limanówka Łukasz , Skubis-Sikora Aleksandra , Kolanko Emanuel , Bogunia Edyta , Hermyt Mateusz , Michalik Marcin , Sikora Bartosz , Prusek Agnieszka , Grajoszek Aniela , Pająk Jacek
Published: August 2022

Background and Aims: Experimental models using carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) can be used in preclinical assessment of acute liver failure (ALF) therapies. Unfortunately, these models are characterized by different dynamics of liver injury depending on the animal strain, administered hepatotoxin, and its dose. The aim of this study was to compare known rat and mouse models of ALF with a view to their future introduction into preclinical cell therapy experiments. In particular, based on histopathological and molecular changes, we suggested experimental time cut-off points for an effective stem cell therapeutic intervention. Methods: ALF was induced by a single intraperitoneal injection of CCl4 in mice (50 μL/100 g b.w.) and rats (200 μL/100 g b.w.) and D-GalN in mice (150 mg/100 g b.w.) and rats (50 mg/100 g b.w.). Blood and liver samples were collected 12 h, 24 h, 48 h and 7 days after intoxication. Blood morphology, liver function blood tests, histopathological changes, proliferation activity, apoptosis, fibrosis, and gene expression were analysed to assess liver damage. Results: At 12 h, 24 h, and 48 h after CCl4 injection, mouse livers showed moderate inflammatory infiltration and massive pericentral necrosis. In rats treated with CCl4, minor lymphocytic infiltration in the liver parenchyma was seen at 12 h, followed by necrosis that appeared around central veins at 24 h and persisted to 48 h. In D-GalN-injected mice, the first histopathological signs of liver injury appeared at 48 h. In the livers of D-GalN-treated rats, moderate pericentral inflammatory infiltration occurred after 12 h, 24 h, and 48 h, accompanied by increased proliferation and apoptosis. All histological changes were accompanied by decreasing expression of certain genes. In most experimental groups of rats and mice, both histological and molecular parameters returned to the baseline values between 48 h and 7 days after intoxication. Conclusions: In mice and rats with CCl4-induced ALF, signs of liver failure can be seen as early as 12 h and develop to 48 h. In the D-GalN-induced model, mice are more resistant to the hepatotoxic effect than rats (after 12 h), and the early hepatitis phase can be observed much later, after 48 h. These cut-off points seem to be optimal for suppressing inflammation and applying effective stem cell therapy for acute liver injury.
Universal Markers for hiPSCs Residue Detection
Authors: Shi Hui , Feng Tiejun , Wang Rui , Wu Lida , Gu Yuchun
Published: August 2022

Background: Residual undifferentiated induced pluripotent stem cells (iPSCs) detection is essential for both Embryonic Stem Cells (ESCs) and iPSCs application in final cell therapy products. However, specific differentiated cells require specific genes for residual detection; identifying the suitable marker is costly and time-consuming. Thus, a universal marker for iPSCs residue detection for all three germline cells would greatly benefit PSC-derived cellular therapies. Methods: Next-generation sequencing (NGS) was performed on total RNAs isolated from the iPSC cell lines and embryonic stem cells (H9), the top 30 expressed genes were selected as candidates. By analysis expression fold change comparing iPSC cells to the differentiated cells, seven genes were highly expressed in iPSCs but showed minimal background expression in differentiated cells. Tissue expression pattern of the candidate genes were explored in the Genotype-Tissue Expression (GTEx) project database, candidate genes were narrowed down to two genes. Spike-in experiments were performed to determine the detection limit and correlation with the number of iPSCs and gene expression by ddPCR. Results: By next-generation sequencing (NGS), we identified two marker genes (ESRG and ZSCAN10) suitable for universal undifferentiated iPSC detection. Both ESRG and ZSCAN10 are highly expressed in iPSCs. ZSCAN10 is slightly expressed in the testis, pituitary, and cerebellum; ESRG is highly expressed in the vagina and scarcely expressed in the other tissues. Furthermore, the ddPCR method with a probe and primers for ESRG and ZSCAN10 detected a trace of undifferentiated hiPSCs to a spiked level of 0.0001%. Conclusions: These results suggest that targeting ESRG/ZSCAN10 transcripts is highly sensitive, quantitative, and could be broadly applied to quality control of almost all iPSC-derived cell therapy products.
Echocardiography in the Diagnosis of Cardiomyopathies: Current Status and Future Directions
Authors: Trasca Livia , Popescu Mihaela Roxana , Popescu Andreea Catarina , Balanescu Serban Mihai
Published: August 2022

Cardiomyopathies are a challenging pathology and echocardiography is essential for diagnosis and prognosis. The most frequent cardiomyopathies are the dilated cardiomyopathy (DCM) and the hypertrophic cardiomyopathy (HCM), followed by the less frequent restrictive (RCM) and arrhythmogenic right ventricle cardiomyopathies (ARVC). Echocardiography can identify diagnostic features, and guide further testing for a definitive diagnosis. Echographic parameters are involved in risk score computing and prognosis assessment. While the most prevalent hallmark of HCM is the asymmetric left ventricular hypertrophy and systolic anterior motion of the mitral valve with the obstructive phenotype, DCM shows dilated left ventricle with different degrees of systolic dysfunction, and RCM is usually characterized by undilated ventricles associated with atrial enlargement. The aim of this review is to display and compare the most frequent cardiomyopathies encountered in clinical practice and highlight their most characteristic features in a useful way for the practicing clinician.
Long-Term Outcomes of Conservative Versus Invasive Approach of Coronary Aneurysm
Authors: Matta Anthony , Campelo-Parada Francisco , Nader Vanessa , Lhermusier Thibault , Bouisset Frédéric , Blanco Stéphanie , Elbaz Meyer , Roncalli Jerome , Carrié Didier
Published: August 2022

Introduction: Up to date, the management of coronary artery aneurysm (CAA) is not well defined and depends on local heart team decision. Data reported in literature are scarce and controversial. We aim to compare the long-term outcomes of different therapeutic strategies of CAA (medical vs percutaneous coronary intervention (PCI) vs coronary artery bypass graft(CABG)). Materials and Methods: A retrospective cohort study was conducted on 100 consecutive patients who underwent coronary angiography at Toulouse University Hospital, Toulouse France and fulfilled the diagnostic criteria of CAA. Coronary angiograms were reviewed, and all necessary data were collected. CAA was defined by a coronary dilation exceedingly at least 50% of reference coronary diameter. Results: We identified 100 patients with CAA with a mean age of 67.9 ± 12 years. The left anterior descending coronary artery was most affected (36%). CAA is associated with significant coronary artery disease in 78% of cases. The incidence of major adverse cardiovascular and cerebrovascular events (MACCE) was 13% during a median follow-up period of 46.2 ± 24 months. A 53% of patients underwent PCI or CABG. The rate of MACCE was lower in CABG group (9.1%) compared to PCI (14.3%) and medical (12.8%) groups, but without reaching statistically significant level. Longitudinal aneurysm diameter was positively linked to MACCE [OR = 1.109, 95% CI (1.014–1.214), p = 0.024]. No benefits have been attributed to anticoagulant regimen over antiplatelet therapy. Conclusions: In our retrospective observational study, there seems to be no significant differences in MACCE-free survival between all groups (Medical vs PCI vs CABG). Larger longitudinal aneurysm diameter was identified as a predictor of poor prognosis during follow-up.
Newer Diabetes Management Options and Physical Fitness to Promote Cardiovascular Benefits
Authors: Nylén Eric
Published: August 2022

A plethora of diabetes studies and established clinical guidelines show the strong salutary benefit of aerobic, resistance, and/or combination exercise for improved glycemic and cardiovascular outcomes. Promotion of physical fitness is a cornerstone approach to improved diabetes management especially since subjects with diabetes have reduced baseline aerobic exercise capacity (i.e., reduced cardiorespiratory fitness) with associated increased risk for premature all-cause and cardiovascular mortality. Since medications are often used in conjunction with fitness promotion this can result in complex interaction between management modalities. More recently, newer options such as glucose transporter-2 inhibitors and incretin agonists have shown to improve cardiovascular disease (CVD) outcomes in cardiovascular outcomes trials. Indeed, both classes of agents have experimentally the potential to synergize with exercise training but clinical data vis-à-vis cardiorespiratory fitness is still preliminary. Review of the interaction of exercise and metformin shows no improvement in cardiorespiratory fitness. The use of glucose transporter-2 inhibitors may improve fitness performance in those with diabetes and heart failure. Although incretin agonists have physiological effects on the vasculature and heart, they lack similar clinical supportive data.
Studies of Online Cohorts for Internalizing symptoms and Language (SOCIAL) I and II: Baseline assessments and rationale
Authors: Lorenzo-Luaces Lorenzo , Howard Jacqueline , Edinger Andrew , Yan Harry , Rutter Lauren , Valdez Danny , Bollen Johan
Published: August 2022

Background: Internalizing, externalizing, and somatoform disorders are the most common and disabling forms of psychopathology. Our understanding of these clinical problems is limited by a reliance on self-report along with research using small samples. Social media has emerged as an exciting venue in which to collect large sample of longitudinal data from individuals to study psychopathology. We report the results of two large ongoing studies in which we collect Twitter data and self-reported clinical screening scales, the Studies of Online Cohorts for Internalizing symptoms and Language (SOCIAL). Methods: Participants were a sample of Twitter-using adults (SOCIAL-I: N= 1123) targeted to be nationally representative in terms of age, sex assigned at birth, and race/ethnicity as well as a sample of college students in the Midwest (SOCIAL-II: N=1988), of which 61% were Twitter users. For all participants who were Twitter users, we asked for access to their Twitter handle which we analyzed with Botometer, an online application rating the likelihood the account belongs to a bot. We divided participants into four groups: 1) Twitter users who did not give us their handle or gave us invalid handles (“Invalid”), 2) those who denied being Twitter users (“No Twitter,” only available for SOCIAL-II), 3) Twitter users who gave their handles but whose account had high bot score (“Bot-like”), and 4) Twitter users who provided their handles and had low bot scores (“Valid”). We explore whether there are significant differences between these groups in terms of their sociodemographic features, clinical symptoms, and aspects of social media use (i.e., platforms used and time). Results: In SOCIAL-I, most individuals were classified as valid (n=580) and few were deemed bot-like (n=190). 353 gave no handle. In SOCIAL-II, many individuals were not Twitter users (n = 760). Of the Twitter users in SOCIAL-II (n = 1, 455), most were classified as either invalid (n = 515) or valid (n = 484), with a smaller fraction deemed bot-like (n = 229). Participants reported high rates of mental health diagnoses as well as high level of symptoms, especially in SOCIAL-II. In general, differences between individuals who provided or did not provide their social media handles were small and not statistically significant. Conclusions: Triangulating passively-acquired social media data and self-reported questionnaires offers new possibilities for large-scale assessment and evaluation of vulnerability to mental disorders. The propensity of participants to share social media handles is likely not a source of sample bias in subsequent social media analytics.
Undersociality is Unwise
Authors: Kumar Amit , Epley Nicholas
Published: August 2022

Wise decisions are often guided by an accurate understanding of the expected values of different possible choices. In social contexts, wisdom comes from understanding how others are likely to respond to one’s actions, enabling people to make choices that maximize both their own and others’ outcomes. Our research suggests that miscalibrated social cognition may create a systematic barrier to wiser decisions in social life. From expressing appreciation to offering support to performing acts of kindness, this program of research indicates that decisions to engage with others are driven by how people expect a recipient to respond, but that people consistently underestimate how positively others will respond to their other-oriented actions. Because connecting with others consistently increases people’s own wellbeing, miscalibrated social cognition may lead to undersociality: being overly reluctant to reach out and connect with others. Miscalibrated expectations about social engagement can create markets for products that help people overcome these barriers in order to consume their time, money, and effort more wisely.