bluuebunny/crossref_metadata_2025 huggingface dataset:
What is the optimal luteal support in assisted reproductive technology?
Authors: Wang Nathalie F. , Bungum Leif , Skouby Sven O.
Published: February 2021

The need for luteal phase support in IVF/ICSI is well established. A large effort has been made in the attempt to identify the optimal type, start, route, dosage and duration of luteal phase support for IVF/ICSI and frozen embryo transfer. These questions are further complicated by the different types of stimulation protocols and ovulation triggers used in ART. The aim of this review is to supply a comprehensive overview of the available types of luteal phase support, and the indications for their use.

A review of the literature was carried out in the effort to find the optimal luteal phase support regimen with regards to pregnancy related outcomes and short and long term safety.

The results demonstrate that vaginal, intramuscular, subcutaneous and rectal progesterone are equally effective as luteal phase support in IVF/ICSI. GnRH agonists and oral dydrogesterone are new and promising treatment modalities but more research is needed. hCG and estradiol are not recommended for luteal phase support. More research is needed to establish the most optimal luteal phase support in frozen embryo transfer cycles, but progesterone has been shown to improve live birth rate in some studies. Luteal phase support should be commenced between the evening of the day of oocyte retrieval, and day three after oocyte retrieval and it should be continued at least until the day of positive pregnancy test.

So, in conclusion still more large and well-designed RCT’s are needed to establish the most optimal luteal phase support in each stimulation protocol, and especially in frozen embryo transfer.
Diversity in osteopathic medical school admissions and the COMPASS program
Authors: Dady Nadege , Mungroo Kelly Ann , Young Ta’Loria , Akinsanya Jemima , Forstein David
Published: February 2021

In the United States, the 37 colleges of osteopathic medicine and 154 schools of allopathic medicine face challenges in recruiting underrepresented minority (URM) applicants, and gaps in racial disparity appear to be widening. In this Special Communication, the authors describe a URM recruitment and support strategy undertaken in 2015 through a special interest group called Creating Osteopathic Minority Physicians who Achieve Scholastic Success (COMPASS) at the Touro College of Osteopathic Medicine—New York.
Effect of occipitoatlantal decompression on cerebral blood flow dynamics as evaluated by Doppler ultrasonography
Authors: Roberts Bryan , Makar Andrew E. , Canaan Ryan , Pazdernik Vanessa , Kondrashova Tatyana
Published: February 2021

Context

Osteopathic manipulative treatment reduces symptoms in patients with headache disorders, but the underlying mechanisms are unclear.

Objective

To evaluate blood flow in the intracranial and extracranial vasculature before and after occipitoatlantal decompression (OAD) using Doppler ultrasonography.

Methods

Healthy, first-year osteopathic medical students from A.T. Still University’s Kirksville College of Osteopathic Medicine participated in a randomized, single-blinded, two-period, two-treatment crossover study. The participants were randomly assigned to 1 of 2 treatment interventions: OAD or sham touch. After one week, participants returned to have the other intervention performed. Blood flow parameters—peak systolic velocity (PSV) and end-diastolic velocity (EDV)—in the middle cerebral artery (MCA), internal carotid artery (ICA), and vertebral artery (VA) were evaluated before, immediately after, 5 minutes after, and 10 minutes after treatment. Differences in PSV, EDV, heart rate (HR), and blood pressure (BP) for both interventions were analyzed for the four time points using mixed-effects models.

Results

Thirty healthy medical students (11 men, 19 women; mean age, 24 years) participated in this study. EDV increased after OAD in the MCA, ICA, and VA (all p<0.001); no change occurred after sham touch (all p>0.05). EDV was greater for all post-treatment timepoints after OAD in the MCA, ICA, and VA than after sham touch (all p<0.001). Although baseline PSV in the MCA measured before treatment was different between treatment interventions (p=0.01), no difference was found between interventions at any post-treatment time point (all p>0.59). Changes in PSV in the ICA and VA and for HR and BP did not depend on treatment intervention (p>0.06).

Conclusion

Increases in EDV occurred in major cranial arteries after OAD but not after sham touch, indicating that OAD improves blood flow to the brain. The exact mechanism of this increase is unknown; however, it can be explained by either parasympathetic stimulation through the secretion of vasodilating neurotransmitters or by a decrease in external tissue pressure on ICA and VA, with the resulting flow causing further dilation in the MCA.
Judith and the Elders of 1 Clement
Authors: Peters Janelle
Published: February 2021

While Judith was used with Esther and other books with female protagonists to promote the reign of Queen Shelamzion Alexandra and the activities of female Pharisees, as Tal Ilan has argued, the role of Judith in the historical examples of 1 Clement presents Judith as needing to seek the permission of the elders of her besieged city in order to go to the enemy camp and behead Holofernes. This article argues that such an interpretive move preserves the authority of Judith in Hasmonean and Pharisaic interpretations.
Classification and Determination Model of Resistance Training Status
Authors: Santos Junior Evaldo Rui T. , de Salles Belmiro F. , Dias Ingrid , Ribeiro Alex S. , Simão Roberto , Willardson Jeffrey M.
Published: February 2021

An individual's training status is a key factor used to determine the volume, the intensity, and the selection of exercises for resistance training prescription. Interestingly, there are no objective parameters to assess training status, so there is ambiguity in determining the appropriate volume and other resistance training variables in this regard. Thus, the objective of this study was to propose a strategy for classification and determination of resistance training status. The following five parameters were identified and used: (a) current uninterrupted training time, (b) time of detraining, (c) previous training experience, (d) exercise technique, and (e) strength level. Moreover, 4 classification levels are proposed: beginner, intermediate, advanced, and highly advanced, which are determined by the mean score of the parameters used. The proposed model represents an important advancement in training status classification and can be used as a valid tool for training prescription and for researchers to better characterize a sample and reproduce results under the same conditions in future studies.
Postnatal Fluoxetine Treatment Alters Perineuronal Net Formation and Maintenance in the Hippocampus
Authors: Mukhopadhyay Sourish , Chatterjee Ashmita , Tiwari Praachi , Ghai Utkarsha , Vaidya Vidita A.
Published: February 2021

Elevation of serotonin via postnatal fluoxetine (PNFlx) treatment during critical temporal windows is hypothesized to perturb the development of limbic circuits thus establishing a substratum for persistent disruption of mood-related behavior. We examined the impact of PNFlx treatment on the formation and maintenance of perineuronal nets (PNNs), extracellular matrix (ECM) structures that deposit primarily around inhibitory interneurons, and mark the closure of critical period plasticity. PNFlx treatment evoked a significant decline in PNN number, with a robust reduction in PNNs deposited around parvalbumin (PV) interneurons, within the CA1 and CA3 hippocampal subfields at postnatal day (P)21 in Sprague Dawley rat pups. While the reduction in CA1 subfield PNN number was still observed in adulthood, we observed no change in colocalization of PV-positive interneurons with PNNs in the hippocampi of adult PNFlx animals. PNFlx treatment did not alter hippocampal PV, calretinin (CalR), or Reelin-positive neuron numbers in PNFlx animals at P21 or in adulthood. We did observe a small, but significant increase in somatostatin (SST)-positive interneurons in the DG subfield of PNFlx-treated animals in adulthood. This was accompanied by altered GABA-A receptor subunit composition, increased dendritic complexity of apical dendrites of CA1 pyramidal neurons, and enhanced neuronal activation revealed by increased c-Fos-positive cell numbers within hippocampi of PNFlx-treated animals in adulthood. These results indicate that PNFlx treatment alters the formation of PNNs within the hippocampus, raising the possibility of a disruption of excitation-inhibition (E/I) balance within this key limbic brain region.
Dynamics of Heading and Choice-Related Signals in the Parieto-Insular Vestibular Cortex of Macaque Monkeys
Authors: Chen Aihua , Zeng Fu , DeAngelis Gregory C. , Angelaki Dora E.
Published: February 2021

Perceptual decision-making is increasingly being understood to involve an interaction between bottom-up sensory-driven signals and top-down choice-driven signals, but how these signals interact to mediate perception is not well understood. The parieto-insular vestibular cortex (PIVC) is an area with prominent vestibular responsiveness, and previous work has shown that inactivating PIVC impairs vestibular heading judgments. To investigate the nature of PIVC's contribution to heading perception, we recorded extracellularly from PIVC neurons in two male rhesus macaques during a heading discrimination task, and compared findings with data from previous studies of dorsal medial superior temporal (MSTd) and ventral intraparietal (VIP) areas using identical stimuli. By computing partial correlations between neural responses, heading, and choice, we find that PIVC activity reflects a dynamically changing combination of sensory and choice signals. In addition, the sensory and choice signals are more balanced in PIVC, in contrast to the sensory dominance in MSTd and choice dominance in VIP. Interestingly, heading and choice signals in PIVC are negatively correlated during the middle portion of the stimulus epoch, reflecting a mismatch in the polarity of heading and choice signals. We anticipate that these results will help unravel the mechanisms of interaction between bottom-up sensory signals and top-down choice signals in perceptual decision-making, leading to more comprehensive models of self-motion perception.

SIGNIFICANCE STATEMENTVestibular information is important for our perception of self-motion, and various cortical regions in primates show vestibular heading selectivity. Inactivation of the macaque vestibular cortex substantially impairs the precision of vestibular heading discrimination, more so than inactivation of other multisensory areas. Here, we record for the first time from the vestibular cortex while monkeys perform a forced-choice heading discrimination task, and we compare results with data collected previously from other multisensory cortical areas. We find that vestibular cortex activity reflects a dynamically changing combination of sensory and choice signals, with both similarities and notable differences with other multisensory areas.
Multi-model intercomparisons of air quality simulations for the KORUS-AQ campaign
Authors: Park Rokjin J. , Oak Yujin J. , Emmons Louisa K. , Kim Cheol-Hee , Pfister Gabriele G. , Carmichael Gregory R. , Saide Pablo E. , Cho Seog-Yeon , Kim Soontae , Woo Jung-Hun , Crawford James H. , Gaubert Benjamin , Lee Hyo-Jung , Park Shin-Young , Jo Yu-Jin , Gao Meng , Tang Beiming , Stanier Charles O. , Shin Sung Soo , Park Hyeon Yeong , Bae Changhan , Kim Eunhye
Published: February 2021

The Korea-United States Air Quality (KORUS-AQ) field study was conducted during May–June 2016 to understand the factors controlling air quality in South Korea. Extensive aircraft and ground network observations from the campaign offer an opportunity to address issues in current air quality models and reduce model-observation disagreements. This study examines these issues using model evaluation against the KORUS-AQ observations and intercomparisons between models. Six regional and two global chemistry transport models using identical anthropogenic emissions participated in the model intercomparison study and were used to conduct air quality simulations focusing on ozone (O3), aerosols, and their precursors for the campaign. Using the KORUSv5 emissions inventory, which has been updated from KORUSv1, the models successfully reproduced observed nitrogen oxides (NOx) and volatile organic compounds mixing ratios in surface air, especially in the Seoul Metropolitan Area, but showed systematic low biases for carbon monoxide (CO), implying possible missing CO sources in the inventory in East Asia. Although the DC-8 aircraft-observed O3 precursor mixing ratios were well captured by the models, simulated O3 levels were lower than the observations in the free troposphere in part due to too low stratospheric O3 influxes, especially in regional models. During the campaign, the synoptic meteorology played an important role in determining the observed variability of PM2.5 (PM diameter ≤ 2.5 μm) concentrations in South Korea. The models successfully simulated the observed PM2.5 variability with significant inorganic sulfate-nitrate-ammonium aerosols contribution, but failed to reproduce that of organic aerosols, causing a large inter-model variability. From the model evaluation, we find that an ensemble of model results, incorporating individual models with differing strengths and weaknesses, performs better than most individual models at representing observed atmospheric compositions for the campaign. Ongoing model development and evaluation, in close collaboration with emissions inventory development, are needed to improve air quality forecasting.
“Like the Flame of Fire”
Authors: Katzew Ilona , Kaplan Rachel
Published: February 2021

The so-called Hearst Chalice at the Los Angeles County Museum of Art (LACMA) is widely regarded as one the most significant works of Mexican silversmithing from the sixteenth century. Its style, technique, and above all its unique combination of materials—including precious metals, feathers, wood carvings, and rock crystal—have led scholars to describe it as the perfect fusion of European and Ancient American (or pre-Columbian) traditions. Surprisingly, despite the consensus about the chalice’s importance, the cultural and artistic conditions that led to the creation of this singular object have not been thoroughly analyzed. By closely examining the different material components of the imposing artifact—which though carefully assembled also stand as independent units—we can better understand its uniqueness and symbolic potential. This essay espouses a synoptic approach by considering a range of agencies, perspectives, and sources—documentary and material—to restore the “Hearst” Chalice to its rightful context, without aspiring to a totalizing view of the past or a definitive decoding of its system of meaning. Categorizing its form and function as purely Indigenous and European poses a distinct set of challenges and limits its hermeneutic possibilities. The work—like many others created during the volatile period following the fall of Tenochtitlan—encodes a new visual language that reveals the highly subtle process of negotiation of these two cultures in a particular space and time. Moving away from the reductive concept of syncretism, the essay offers a fresh look at this impressive contact period work and its shifting values over time.
Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study
Authors: Albertelli M , Nazzari E , Dotto A , Grasso L F , Sciallero S , Pirchio R , Rebora A , Boschetti M , Pivonello R , Ricci Bitti S , Colao A A L , Ferone D
Published: February 2021

Context

Colonic polyps occur in 30–40% of acromegalic patients, increasing the risk of colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role in diabetic and non-diabetic patients with colonic polyps and its use in chemoprevention is currently explored.

Objective

Evaluate the prevalence of colonic polyps in acromegalic patients treated or not with metformin and explore its possible protective role.

Design

Exploratory cross-sectional study in two tertiary Italian referral centres.

Met

hods: Out of 153 acromegalic patients, we selected 58 patients (36–82 years; f: 33) who had at least one colonoscopy performed within the first 2 years of diagnosis. Presence of colonic polyps/cancer and related risk factors, current metformin and acetylsalicylic acid intake, disease duration, therapies for acromegaly, hormonal and metabolic parameters were assessed.

Results

An overall prevalence of 36% polyps was found. Based on the presence of polyps, we identified two groups, comparable for age, BMI, disease duration, glucose, insulin, HOMA-IR, HbA1c, GH and IGF-I levels. Of the patients with polyps (including three adenocarcinomas) only 24% were treated with metformin vs 57% of patients without polyps. Multivariate analysis confirmed a significant negative association between colonic polyps and metformin intake (OR: 0.22, 95% CI: 0.06-0.77, P = 0.01), whereas no significant association was found between polyps and age (P = 0.10), overweight/obesity (P = 0.54), smoking (P = 0.15), acetylsalicylic acid intake (P = 0.99), disease duration (P = 0.96), somatostatin analogues treatment (P = 0.70).

Conclusions

These findings, though deriving from an exploratory study, could suggest a protective role of metformin on the development of colonic polyps in acromegaly, and need to be confirmed in an extended study population.
Impact of Acute and Chronic Hypoxia-Ischemia on the Transitional Circulation
Authors: Sehgal Arvind , Allison Beth J. , Miller Suzanne L. , Polglase Graeme R. , McNamara Patrick J. , Hooper Stuart B.
Published: February 2021

The transition from intrauterine life to extrauterine existence encompasses significant cardiorespiratory adaptations. These include rapid lung aeration and increase in pulmonary blood flow (PBF). Perinatal asphyxia and fetal growth restriction can severely hamper this transition. Hypoxia is the common denominator in these 2 disease states, with the former characterized by acute insult and the latter by utero-placental insufficiency and a chronic hypoxemic state. Both may manifest as hemodynamic instability. In this review, we emphasize the role of physiologic-based cord clamping in supplementing PBF during transition. The critical role of lung aeration in initiating pulmonary gas exchange and increasing PBF is discussed. Physiologic studies in animal models have enabled greater understanding of the mechanisms and effects of various therapies on transitional circulation. With data from sheep models, we elaborate instrumentation for monitoring of cardiovascular and pulmonary physiology and discuss the combined effect of chest compressions and adrenaline in improving transition at birth. Lastly, physiologic adaptation influencing management in human neonatal cohorts with respect to cardiac and vascular impairments in hypoxic-ischemic encephalopathy and growth restriction is discussed. Impairments in right ventricular function and vascular mechanics hold the key to prognostication and understanding of therapeutic rationale in these critically ill cohorts. The right ventricle and pulmonary circulation seem to be especially affected and may be explored as therapeutic targets. The role of comprehensive assessments using targeted neonatal echocardiography as a longitudinal, reliable, and easily accessible tool, enabling precision medicine facilitating physiologically appropriate treatment choices, is discussed.
La irrupción del tractor en los caminos de la pampa bonaerense a finales de la década de 1950 y principios de la de 1960: significados, usos y conflictos
Authors: Salomón Alejandra
Published: February 2021

Dentro de los recientes estudios rurales la movilidad ha cobrado creciente interés académico, pero su historia mantiene enormes vacíos, a pesar de encontrase atravesada por significados, experiencias y conflictos que trascienden el tiempo presente. Frente a tal situación, la propuesta del artículo consiste en examinar las implicancias sociopolíticas de la irrupción del tractor en la pampa bonaerense (Buenos Aires, Argentina) a finales de la década de 1950 y principios de la de 1960, en un análisis que considera a esta máquina menos como elemento de trabajo y más como medio de transporte. En particular, se estudiarán, por un lado, sus valores ambivalentes —progreso versus destrucción— y su utilización como vehículo no convencional de desplazamiento de personas y productos; y, por otro lado, se tratará la acción estatal —punitiva y educativa— con respecto al deterioro de caminos rurales que tales prácticas de movilidad generaron. Por medio de un corpus diverso de fuentes textuales y visuales se demostrará que la mecanización ocurrida en el agro bonaerense trascendió el ámbito meramente productivo y desencadenó perjuicios viales y desafíos al ordenamiento normativo de tránsito.
El sexo en disputa: regulación y materialización corporal del género en un contexto de despatologización de la identidad
Authors: Meske Verónica , Antoniucci Melina
Published: February 2021

En el presente artículo, recuperamos enfoques sociales críticos de la medicina y desarrollos de los estudios de género, feministas y queer para caracterizar las biopolíticas de género contemporáneas. Nos preguntamos por las particularidades que presenta el escenario local en la regulación y materialización del género, a partir de los procesos de despatologazión y desjudicialización de la identidad de género enmarcados en la Ley 26.743. Desde una perspectiva cualitativa de investigación, y a través de entrevistas autoadministradas a residentes de la ciudad de Mar del Plata que hayan participado en la visibilización de las demandas de travestis, trans y no-binaries ante el faltante de tratamientos hormonales involucrados en el derecho integral a la salud, abordaremos las estrategias de gestión del acceso a modificaciones corporales, advirtiendo el rol mediador del Estado en relación al mercado farmacológico y las expectativas y evaluaciones del trato recibido por parte de profesionales de la salud. Identificaremos la tensión en los sentidos asignados al “sexo” y al “género” entre estas demandas y las respuestas médicas, así como advertimos que el campo de la medicina retiene su autoridad en la regulación del “sexo”, principalmente a través del diagnóstico como mediador del acceso a intervenciones quirúrgicas.
Screening some Common Molecular Markers and a Desaturase Marker, Linked to Sex Pheromone Biosynthesis, in Three Z-Strain and an E-Strain Populations of the European Corn Borer, Ostrinia nubilalis, Occurring in Central Europe
Authors: Bozsik G. , Lakatos A. , Szőcs G. , Tóbiás I.
Published: February 2021

The European corn borer moth, (ECB), Ostrinia nubilalis
(Lepidoptera: Crambidae, Pyraustinae) is one of the most destructive pests of
maize worldwide. ECB has two pheromone-strains, separated by specific ratios of
isomers of E- and Z11-tetradecenyl acetates (E11- and Z11-14Ac), but appearing
morphologically identical. Accordingly, E- and Z-ECB pheromone traps are
available for the respective populations for practical monitoring of the flight,
however, traps for Z-strain are unreliable for practical usage in some parts of
Central-Europe. E- and Z-ECB populations occur in sympatry in some areas, while
in allelopatry in other areas. Determining the strains before the flight of
adults, when difference in the composition of their respective pheromones is
manifested, would be of practical interest for early warning. In addition to the
known fatty-acyl-reductase (FAR) marker, further markers would allow more
comprehensive studies. We screened the following common markers for
mitochondrial and nuclear DNA regions: partial cytochrome c oxidase I (COI),
cytochrome B (CytB), the second spacer of the internal transcribed spacer
(ITS2), Elongation factor 1a (EF1a) and actin gene (Act). In addition, a marker
of the Δ11-desaturase gene (11desat), linked to biosynthesis of female-produced
sex pheromone, was also included, because we reported earlier a differential
expression for this site. Three Z-ECB populations locating at distant sites
within Hungary, an area where only Z-strain occurs, and an E-ECB population in
Slovenia, known as the closest-occurring E-strain, were included into the study.
Separate laboratory colonies were established from each population, and
F1 generations were sampled to verify the identity of pheromone
strains, by analysing the composition of sex pheromone by gas chromatography
linked to an electroantennographic detector (GC-EAD). Molecular studies were
conducted using specimens taken from the F2 generations. Results of
genetic studies showed that there were no differences between the Z and E
populations for the common markers. In contrast to this, several nucleic acid
changes (11 nt in 4 positions) were found between the three Z-populations
(Hungary) and the E-population (Slovenia) in the desaturase marker. Further
study is required to reveal whether the differences found in this study are
consistent across E-populations, thus making these markers suitable for
diagnostic purposes.
First record of Stiphodon annieae Keith & Hadiaty, 2014 (Teleostei, Oxudercidae) from Sulawesi Island, Indonesia
Authors: Gani Abdul , Nurjirana Nurjirana , Bakri Achmad , Adriany Devita , Wuniarto Erwin , Khartiono Lady , Satria Dawam Heksa , Hasan Veryl , Herjayanto Muh. , Burhanuddin Andi Iqbal , Moore Abigail Mary , Kobayashi Hirozumi
Published: February 2021

The recently described Stiphodon annieae (Keith & Hadiaty, 2014) was thought to be endemic to Halmahera Island, Indonesia. However, from August 2019 to January 2020, we collected several specimens during field trips to the Soho, Simpong, and Uso rivers in Luwuk Banggai, Central Sulawesi, Indonesia. We describe specimens collected in the Soho River and discuss the ichthyofauna of Luwuk Banggai. This is the first report of S. annieae from Sulawesi. Our records represent a range extension of approximately 500–600 km west of this species’ type locality on the island of Halmahera. 
Theoretical model of guided waves in a bone-mimicking plate coupled with soft-tissue layers
Authors: Nguyen Hoai , Le Ductho , Plan Emmanuel , Dang Son Tung , Phan Haidang
Published: February 2021

Quantitative ultrasound has shown a significant promise in the assessment of bone characteristics in the recent reports. However, our understanding of wave interaction with bone tissues is still far from complete since the propagation of ultrasonic waves in bones is a very challenging topic due to their multilayer nature. The aim of the current study is to develop a theoretical model for guided waves in a bone-mimicking plate coupled with two soft-tissue layers. Here, the bone plate is modeled as an isotropic solid layer while the soft tissues are modeled as fluid layers. Based on the boundary conditions set for the three-layered structure, a characteristic equation is obtained which results in dispersion curves of the phase and group velocities. New expressions for free guided waves propagating in the trilayered plate are introduced. The amplitudes of wave modes generated by time-harmonic loads applied in the plate are theoretically computed by reciprocity consideration. As an example of calculation, the normalized amplitudes of the lowest wave modes are presented. The obtained results and equations discussed in this study could be, in general, useful for further applications in the area of bone quantitative ultrasound.
Kajian Literatur Efektivitas Electronic Word Of Mouth (E-Wom) Dalam Meningkatkan Minat Beli Konsumen Di Sosial Media
Authors: Damayanti Yosinta
Published: February 2021

Today the development of technology is very fast, especially in the field of marketing. One of the proof is the emergence of Electronic Word of Mouth or e-WOM which is the next development of Word of Mouth or WOM. E-WOM is a support facility of businessmen in providing perceptions of good value for customers on social media. E-WOM used as communication in the marketing field on social media is offered to increase consumer buying interest in the products offered. E-WOM contains shared messages by consumers that related to purchases products, and can be used as a medium for delivering information related to products, both in terms of quality, or in terms of service provided by the seller. A lot of the companies have successfully understood the power of electronic word of mouth (e-WOM) on social media, this can be seen from the proliferation of companies offering their products on social media by using e-WOM to provide good advice from the sale of products. The purpose of this research is to provide scientific development and insight related to the effectiveness of Electronic Word of Mouth (e-WOM) in increasing the purchase interest of consumers. The type of research used is descriptive qualitative with the study literature method. Overall, the results of this literature review can conclude that Electronic Word of Mouth (e-WOM) can increase purchase interest of consumers on social media. The results are supported by several studies that show e-WOM can increase purchase interest of the consumer on social media.
Faktor-Faktor Yang Mempengaruhi Kepatuhan Aparatur Pemerintah Atas Prosedur Pengadaan Barang/Jasa
Authors: Agustina Nenny Dwi
Published: February 2021

Penelitian ini bertujuan untuk mengetahui faktor-faktor apa sajakah yang mempengaruhi kepatuhan aparatur pemerintah atas peraturan pengadaan barang/jasa. Penelitian ini merupakan confirmatory research yang dilaksanakan di instansi pemerintah yang berada di bawah naungan Pemerintah Kabupaten Kediri dengan desain penelitian survey dan kuesioner sebagai instrumen penelitian. Terdapat 116 responden dari 8 instansi pemerintah di kabupaten Kediri yang ikut berpartisipasi dalam pengumpulan data yang kemudian dianalisis dengan alat uji regresi dengan bantuan program SPSS versi 20. Hasil studi menunjukkan bahwa : (1) SPI berpengaruh positif dan signifikan terhadap kepatuhan aparatur pemerintah, (2) sistem kompensasi tidak berpengaruh terhadap kepatuhan aparatur pemerintah, (3) kecerdasan emosi berpengaruh positif dan signifikan terhadap kepatuhan aparatur pemeriintah, (4) pengamalan nilai-nilai spiritual terhadap kepatuhan aparatur pemerintah dan (5) SPI, sistem kompensasi, kecerdasan emosi, dan pegamalan nilai-nilai spiritual secara simulatan berpengaruh terhadap kepatuhan aparatur pemerintah. Artinya bahwa peran SPI dan kecerdasan emosi dapat terbukti efektif meningkatkan kepatuhan aparatur pemerintah.
Pengembangan Model Pemasaran Layanan Uinsa Halal Center (UHC) Untuk Mendukung Peningkatan Pendapatan Bisnis Kampus
Authors: Putranto Hanafi Adi
Published: February 2021

Fenomena produk halal dan disahkannya Undang-Undang terkait Jaminan Produk Halal menjadi tren industri halal. Dengan diterbitkannya regulasi tersebut, banyak perguruan tinggi yang mendirikannya untuk mengakomodir kepentingan masyarakat. Penelitian ini bertujuan untuk membentuk pengembangan model pemasaran di UINSA Halal Center. Usaha yang dilakukan pengelola lembaga dengan pengembangan model pemasaran yang berafiliasi terkait produk layanan halal yang tersedia. Dari sisi pemasaran, perlu pengembangan model pemasaran yang inovatif untuk menyokong berjalannya proses bisnis tersebut. Pada penelitian ini pengembangan model pemasaran diketahui dari hasil pengumpulan data-data observasi yang terperinci. Metode penelitian menggunakan pendekatan kualitatif. Sumber data penelitian terdiri dari sumber data primer dan sumber data sekunder. Sumber data primer diperoleh langsung dari wawancara. Hasil dari penelitian sebagai berikut: (1) Tersedianya peralatan, fasilitas dan sumber daya manusia yang dibutuhkan UINSA Halal Center. (2) Model pemasaran layanan UINSA Halal Center yang sesuai dalam mendukung peningkatan pendapatan kampus melalui; Pemasaran berbasis layanan kebutuhan pokok dan Pemasaran berbasis layanan bahan baku. (3) Kolaborasi bisnis menjadi role model antar lembaga/unit di UIN Sunan Ampel Surabaya untuk peningkatan pendapatan kampus.
Desain Balanced Scorecard Terintegrasi Dengan Pendekatan Six Sigma
Authors: Supriadi Iman
Published: February 2021

The motivation behind this paper is to give new bits of knowledge into understanding the estimation of incorporating the Balanced Scorecard with Six Sigma. This paper depends on an exhaustive writing audit from BSC and Six Sigma. The writing survey gives the premise to another joining system dependent on the PDCA cycle. The discoveries of this paper show how coordinated frameworks can add further esteem contrasted with the autonomous execution of either BSC or Six Sigma. This investigation gives a structure that can fill in as a reason for the reconciliation of Six Sigma with BSC. This paper adopts another strategy to joining structures by recognizing purposes of incorporation influence through the qualities and shortcomings of BSC and Six Sigma. The fundamental commitment of this paper is that it gives new experiences into seeing how BSC can be coordinated with Six Sigma. In addition, this paper gives guidance for future research that will defeat shortcomings in the manner associations are coordinating BSC with Six Sigma today.
Pengaruh Quality Awareness Dan Brand Image Terhadap Customer Satisfaction Pada Produk Wardah
Authors: Qanita Ariza , Albab Zackya Ulul
Published: February 2021

Penelitian ini bertujuan untuk menguji pengaruh antara kesadaran kualitas (Quality Awareness) dan citra merek (Brand Image) terhadap kepuasan pelanggan (Customer Satisfaction) pada produk kosmetik Wardah. Metode penelitian yang digunakan adalah kuantitatif dengan teknik analisis regresi linier berganda menggunakan Statistical Process Social Science (SPSS). Objek penelitian ini adalah pengguna kosmetik Wardah dari berbagai jenis produk yang berjumlah sebanyak 71 responden. Hasil penelitian menunjukkan bahwa Quality Awareness dan Brand Image berpengaruh terhadap Customer Satisfaction baik secara parsial maupun secara simultan. Quality awareness berpengaruh signifikan terhadap customer satisfaction dengan koefisien regresi sebesar 0,595. Brand Image berpengaruh signifikan terhadap customer satisfaction dengan koefisien regresi sebesar 0,348. Quality awareness dan brand image secara berkesinambungan berpengaruh terhadap customer satisfaction dan dapat menjelaskan 74,3% dari variasi variabel customer satisfaction. Wardah sebaiknya lebih mengutamakan penjagaan kualitas karena hal tersebutmempunyai pengaruh yang lebih besar terhadap kepuasan pelanggan.
Strategi Marketing Mix Dalam Menghadapi Pandemi Covid-19 (Studi Kasus Pada Jolly Coffee Surabaya)
Authors: Ningsih Siti Nur Wahyu , Milasari Aida Octavia , Saifuddin Muchammad
Published: February 2021

The cafe business in Indonesia is increasingly increased its growth. This is a business field for business activists. Surely a cafe has its own marketing system or what we can call a Marketing Mix. The purpose of this study is to identify the implementation of marketing strategies in cafes in Indonesia, especially in Surabaya. This research uses qualitative methods, namely through observation, document study and interviews with several relevant informants. The results of this study indicate that Cafe Jolly Coffee Surabaya uses a marketing strategy which I believe is appropriate to attract consumer interest and is also used to compete in the cafe sector.
Automated Computational Detection of Interstitial Fibrosis, Tubular Atrophy, and Glomerulosclerosis
Authors: Ginley Brandon , Jen Kuang-Yu , Han Seung Seok , Rodrigues Luís , Jain Sanjay , Fogo Agnes B. , Zuckerman Jonathan , Walavalkar Vighnesh , Miecznikowski Jeffrey C. , Wen Yumeng , Yen Felicia , Yun Donghwan , Moon Kyung Chul , Rosenberg Avi , Parikh Chirag , Sarder Pinaki
Published: February 2021

Significance Statement

Reliable, digital, automated detection of interstitial fibrosis and tubular atrophy (IFTA) has not yet been developed. Machine learning (ML) can reproduce the renal pathologist’s visual assessment of IFTA and glomerulosclerosis. Well-trained ML methods not only showed similar agreement to that seen among renal pathologists for the assessment of IFTA and glomerulosclerosis, but also equivalent statistical association with patient outcome. These methods can help expedite research on very large digital archives of renal biopsy specimens, and may also benefit clinical practice by acting as a stand-in reading for pathology scenarios where renal expertise is limited or unavailable.

Background

Interstitial fibrosis, tubular atrophy (IFTA), and glomerulosclerosis are indicators of irrecoverable kidney injury. Modern machine learning (ML) tools have enabled robust, automated identification of image structures that can be comparable with analysis by human experts. ML algorithms were developed and tested for the ability to replicate the detection and quantification of IFTA and glomerulosclerosis that renal pathologists perform.

Methods

A renal pathologist annotated renal biopsy specimens from 116 whole-slide images (WSIs) for IFTA and glomerulosclerosis. A total of 79 WSIs were used for training different configurations of a convolutional neural network (CNN), and 17 and 20 WSIs were used as internal and external testing cases, respectively. The best model was compared against the input of four renal pathologists on 20 new testing slides. Further, for 87 testing biopsy specimens, IFTA and glomerulosclerosis measurements made by pathologists and the CNN were correlated to patient outcome using classic statistical tools.

Results

The best average performance across all image classes came from a DeepLab version 2 network trained at 40× magnification. IFTA and glomerulosclerosis percentages derived from this CNN achieved high levels of agreement with four renal pathologists. The pathologist- and CNN-based analyses of IFTA and glomerulosclerosis showed statistically significant and equivalent correlation with all patient-outcome variables.

Conclusions

ML algorithms can be trained to replicate the IFTA and glomerulosclerosis assessment performed by renal pathologists. This suggests computational methods may be able to provide a standardized approach to evaluate the extent of chronic kidney injury in situations in which renal-pathologist time is restricted or unavailable.
Machine-Part Formation for Cellular Manufacturing in Group Technology: An Application for Furniture Company
Authors: GÜVEN İlker , ŞİMŞİR Fuat
Published: February 2021

Group technology’s basic logic is grouping and producing products of the same type together. An important reason behind Group Technology becoming such an important topic is that nowadays companies have quite an extensive range and workshop type production has increased. Both fuzzy clustering and rank order clustering methods use for grouping parts and machines based on a part-machine matrix created from the production flow technique in order to increase productivity and reduce cost and workmanship required. In this study, Group Technology techniques such as the rank order clustering and fuzzy clustering methods were applied in order to increase the efficiency of the production line, reduce transportation between machines, and form a machine-parts groups in the wood cutting department of a furniture company producing modular furniture in Istanbul. The TOPSIS method was used to determine which products to take into account. According to results of the study, it is shown that fuzzy clustering method has overperformed rank order clustering method based on the evaluation criteria which are group productivity with 21,36%, group efficiency with 43,21% and grouping measure with 82,33%.
Un modelo educativo para la clasificación de factores que afectan la eficiencia de la reurbanización del entorno y la reubicación de empresas industriales
Authors: Lapidus Azariy
Published: February 2021

El propósito de este estudio fue determinar la jerarquía de factores fundamentales que determinan la posibilidad de reubicación de empresas industriales para racionalizar la infraestructura urbana. Mediante el análisis de la literatura científica y el método de evaluación de expertos, se ha elaborado una lista de factores prioritarios que inciden en la posibilidad de reurbanización del entorno urbano y la reubicación de una instalación industrial. El uso de la evaluación experta y la escala Likert estableció relaciones causales entre factores, se ha desarrollado un modelo de jerarquía de factores mediante el método gráfico, a partir de cuyos resultados se ha establecido una estructura de factores de 5 niveles que inciden en la posibilidad de remodelación del entorno urbano y reubicación de una instalación industrial. Los resultados obtenidos pueden ser útiles para estructuras empresariales, así como para organismos gubernamentales. Parece que una consideración más completa de los siguientes factores no protegerá por completo los proyectos para el redesarrollo de zonas industriales en las ciudades rusas de elegir los conceptos incorrectos, no de la recuperación, el bajo interés de los turistas, sino que reducirá la probabilidad de que no decisiones óptimas.
Typha (Cattail) Crosslinking and Nuclei Isolation v2
Authors: Colt Kelly
Published: February 2021

Typha Crosslinking and Nuclei Isolation protcol Key notes: Allow for extra time if working with pre-ground samples. Crosslinking steps and subsequent washes will take longer to complete. 1% Triton X-100 600g pelleting Optional supernatant recovery steps
Patterns of ocular morbidity among kidney transplant recipients in Ethiopia
Authors: Tamrat Lemlem , Gebrehanna Ewenat
Published: February 2021

Background: Of all organ transplant procedures renal transplantation has become a very successful and routine procedure. Saint Paul’s Hospital Millennium Medical College is a pioneer and is the only center providing kidney transplant in Ethiopia. Even if this is a life changing and exiting addition to the countries’ health service coverage, its long term outcomes including various complications is not yet assessed. Therefore, the aim of this study is to describe ocular morbidities among kidney transplant recipients in Ethiopia.  

Methods: Cross sectional descriptive study was undertaken from October 2017 to December 2018.  

Results: There were a total of 135 individuals who underwent renal transplant procedure including 95 (70.4%) male and 40 (29.6 %) female. The median age was 32 years. The cause of renal diseases is not known in majority 112 (83%) of the study subjects. More than 95% of all the study subjects were on multiple immunosuppressant therapy. Of all the individuals examined 128 (94.8%) of them have one or more ocular morbidities. Dry eye 76 (50.7%), optic neuropathies 12 (8%), retinal pigmentary changes 11 (7.3%) and cataract 9 (6%) were frequently observed eye morbidities. There were no significant sight threatening conditions observed in relation to the immunosuppressive therapy or the diseases itself.

Conclusions: Dry eye is the commonest eye morbidity among kidney transplant patients.
Impact of gas flaring on communities in Delta region of Nigeria, narrative review part 1: environmental health perspective
Authors: Obi Nkem , Akuirene Alero , Bwititi Phillip , Adjene Josiah , Nwose Ezekiel
Published: February 2021

Gas flaring is the combustion of associated gas from crude-oil exploitation and exploration operations and occurs in refineries, oil wells, oil rigs by fiery of the gas. Nigeria is one of the main producers of gas in the world and oil exploration activities have occasioned high rate of gas flaring because of poor enforcement of anti-gas flaring laws by the regulatory authorities. Gas flaring comes with serious environmental concern because it is a major source of air pollution with adverse public health consequences particularly in the gas flaring communities. The objective of this narrative review is to identify the risks associated with gas flaring in relation to the environment. Literatures from diverse databases including peer reviewed journals as well as governmental and organizational papers were searched to develop the narrative. Over the years, several laws have been enacted in Nigeria with stipulated dates to end gas flaring, but the targets have not been met. The Federal government of Nigeria updated the legal framework titled flare gas (prevention of waste and pollution) regulations, 2018 to facilitate financial profits through utilization and commercialization of associated gas, with a view to reduce or exterminate flaring. This effort appears ineffective due to weak enforcement and poor monitoring mechanism. The statutory government institution entrusted to enforce anti-gas law may benefit from some sort of motivation to ensure oil operators comply to combat environmental health risks from gas flaring.
Leyendo al lector social
Authors: Sánchez-García Patricia , Hernández-Ortega José , Rovira-Collado José
Published: February 2021

El concepto de lectura social responde a las posibilidades que ofrece en la actualidad Internet para hablar de libros y literatura a través de diversos medios y aplicaciones digitales creando comunidades lectoras. Las redes sociales lectoras son espacios específicos para esta práctica digital ya que recogen en una única aplicación distintas maneras de interacción relacionadas con la literatura. Entre todas, Goodreads, adquirida por Amazon en 2013, es el principal espacio por usuarios y número de libros reseñados. Esta investigación analiza la presencia de la literatura infantil y juvenil española a través de un corpus de 19 libros entre 2016 y 2019, 353 usuarios y 558 reseñas. Se define el proceso de análisis de la red a través de distintos apartados y se recogen resultados de la presencia de las citadas obras para demostrar el interés de esta plataforma como espacio de investigación sobre la lectura social.
Topology optimization of clutch drive plate for commercial vehicles
Authors: ERDOĞAN Özgür
Published: February 2021

he drive plate is one of the main components of the clutch disc which transmits the torque from engine to transmission. For commercial vehicle applications, the drive plate works under immense torsional forces thanks to high engine torque values. Therefore, high durability is expected during the operational life of the clutch disc drive plate. On the other hand, the lightweight of the vehicle components has an important role in CO2 emission standards. To be able to assure this regulation, companies conduct studies for decreasing the vehicle mass. In this study, the drive plate's 3D CAD data is created based on the current design by using CATIA solid creation software. Finite Element Analysis (FEA) was carried out in a statical analysis tool and to be verified for real-life working conditions. The topology optimization was performed using CAE software (ANSYS) in order to reduce the weight of the drive plate without compromising on mechanical durability. The optimized design was proposed based on topology optimization outputs. The strength of the proposed design was investigated by using FEA analysis and results are compared to the acceptance criteria of the material. The optimized geometry is equally durable and lighter in weight compared to the existing model. Mass was decreased %18 without compromising mechanical durability.