bluuebunny/crossref_metadata_2025 huggingface dataset:
Rhizobacterial diversity, community composition, and the influence of keystone taxa on O’Neal blueberry (Vaccinium corymbosum)
Authors: Jia Mingyun , Liu Zhuangzhuang , Wei Jiguang , Li Qi , Hou Zhaoqi , Sun Ling , Yu Hong , Yu Jinping , Lu Shipeng
Published: September 2024

Rhizosphere microbiotas play vital roles in resisting environmental stress, transforming soil nutrients, and promoting plant health, growth, and productivity. The effects of rhizosphere microbial community shaping and the characteristics and functions of keystone taxa on blueberries were comprehensively studied by examining the rhizobacteria of healthy old trees (O), young seedlings (OG), and poorly growing seedlings (OB) of O’Neal blueberries. Our results showed that rhizobacterial diversity followed the order OB > > OG > O, and the microbial community of OG was similar to that of O, while that of OB was distinctly different. The predominant rhizobacteria identified included Actinobacteria, Proteobacteria, Firmicutes, Chloroflexi, and Acidobacteria. Firmicutes were highly enriched in healthy blueberries, with Bacillus identified as a key genus that significantly enhanced blueberry growth when inoculated. Bradyrhizobium and Gaiellales were common core bacteria in the blueberry rhizosphere. In contrast, Acidobacteria were the predominant phylum in poorly growing OB, with the specific Vicinamibacterales-related and Latescibacterota-related genera acting as keystone taxa that shaped the microbial community. In addition, bacterial species in Vicinamibacterales might act as a potential pathogen predicted by BugBase. Taken together, these findings provide fundamental insights into the development of the blueberry rhizosphere microbial community and highlight the role of beneficial rhizobacteria, such as Bacillus, in enhancing blueberry growth. This knowledge could contribute to the exploitation of beneficial rhizobacteria and the prevention of pathogens in modern agriculture.
Identification and mechanistic analysis of neurovascular coupling related biomarkers for diabetic macular edema
Authors: Chen Tianpeng , Sheng Shufan , Chen Jing , Wang Xiaole , Shang Yanxing , Duan Chengwei , Liang Caixia , Song Yu , Zhang Dongmei
Published: September 2024

Introduction

Diabetic macular edema (DME) is a major cause of vision loss in the sick with diabetic retinopathy. The occurrence of DME is closely related to the breakdown of neurovascular coupling; however, its underlying mechanism has not been fully elucidated. The aim of this study was to investigate the diagnostic biomarkers and potential molecular mechanisms associated with neurovascular coupling in DME.

Methods

The differential expression analysis, STEM, and WGCNA were performed from GSE160306 to identify hub genes. The gene expression was validated by RT-qPCR. The relevant mechanisms of action were investigated through GO, KEGG, and GSEA analyses, as well as co-expression networks. Additionally, the LASSO regression analysis and a nomogram were used to demonstrate the diagnostic effectiveness of the model. Finally, the GenDoma platform was utilized to identify drugs with potential therapeutic effects on DME.

Results

Neurotrophic factor receptor (NGFR) was identified as a hub gene related to neurovascular coupling and DME. The expression of NGFR was verified by RT-qPCR in vitro cells. GSEA analysis indicated that high expression of NGFR may affect immunity and inflammatory pathway, thereby regulating neurovascular coupling and mediating the development of DME. The NGFR co-expression network was constructed, which exhibited the correlation with the neurotrophin signaling pathway. Moreover, a diagnostic model for DME based on NGFR and PREX1 demonstrated relatively good diagnostic performance using LASSO regression analysis and the nomogram. And then the GenDoma platform identified drugs with potential therapeutic effects on DME.

Conclusion

The high expression of NGFR may lead to abnormal neurovascular coupling and participate in the occurrence of DME by regulating the immunity, inflammatory and neurotrophin signaling pathway. Detection of NGFR and related expression genes may be beneficial for monitoring the occurrence and development of DME.
Electrically evoked late latency response using single electrode stimulation and its relation to speech perception among paediatric cochlear implant users
Authors: Saravanan Palani , Devi Neelamegarajan , Geetha Chinnaraj
Published: September 2024

Introduction

Aided auditory late latency response (LLR) serves as an objective tool for evaluating auditory cortical maturation following cochlear implantation in children. While aided LLR is commonly measured using sound-field acoustic stimulation, recording electrically evoked LLR (eLLR) offer distinct advantages, such as improved stimulus control and the capability for single electrode stimulation. Hence, the study aimed to compare eLLR responses with single electrode stimulation in the apical, middle, and basal regions and to evaluate their relationship with speech perception in paediatric cochlear implant (CI) recipients.

Method

eLLR responses with single electrode stimulation were measured in 27 paediatric unilateral CI users with an active recording electrode placed at Cz. The stimuli consisted of 36 msec biphasic pulse trains presented across three electrode sites (apical-E20, middle-E11, and basal-E03). eLLR responses were compared across these electrode sites, and the relationship between speech recognition scores in quiet and age at implantation with eLLR components was evaluated.

Results

eLLR responses were detected in 77 out of 81 tested electrodes of all participants combined (27 for apical, 26 for middle, and 24 for basal stimulation). There were no significant differences in P1, N1 latencies and P1 amplitude across electrode site. However, significantly larger N1 and P1-N1 amplitudes were observed for apical stimulations compared to basal stimulations. No differences in N1 amplitude were found between middle and apical stimulations, and the P1-N1 amplitude was significantly larger for middle compared to basal electrode stimulation, with no difference between the apical and middle electrodes stimulation. A moderate positive correlation was present between speech recognition scores in quiet and both N1, P1-N1 amplitudes for apical stimulation. Age at implantation was negatively correlated with N1 amplitude for the apical and P1-N1 amplitude for basal stimulation.

Discussion

eLLR responses could be elicited in majority of paediatric CI users across electrode sites. Variations in eLLR responses across electrode sites suggest disparities in auditory cortical maturation. The findings underscore the significance of the N1 biomarker in evaluating higher-order auditory cortical development. Therefore, utilizing eLLR with single electrode stimulation may serve as a valuable tool for assessing post-cochlear implantation maturational changes in paediatric populations.
Detecting fatigue in multiple sclerosis through automatic speech analysis
Authors: Dias Marcelo , Dörr Felix , Garthof Susett , Schäfer Simona , Elmers Julia , Schwed Louisa , Linz Nicklas , Overell James , Hayward-Koennecke Helen , Tröger Johannes , König Alexandra , Dillenseger Anja , Tackenberg Björn , Ziemssen Tjalf
Published: September 2024

Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by central nervous system demyelination and axonal degeneration. Fatigue affects a major portion of MS patients, significantly impairing their daily activities and quality of life. Despite its prevalence, the mechanisms underlying fatigue in MS are poorly understood, and measuring fatigue remains a challenging task. This study evaluates the efficacy of automated speech analysis in detecting fatigue in MS patients. MS patients underwent a detailed clinical assessment and performed a comprehensive speech protocol. Using features from three different free speech tasks and a proprietary cognition score, our support vector machine model achieved an AUC on the ROC of 0.74 in detecting fatigue. Using only free speech features evoked from a picture description task we obtained an AUC of 0.68. This indicates that specific free speech patterns can be useful in detecting fatigue. Moreover, cognitive fatigue was significantly associated with lower speech ratio in free speech (ρ = −0.283, p = 0.001), suggesting that it may represent a specific marker of fatigue in MS patients. Together, our results show that automated speech analysis, of a single narrative free speech task, offers an objective, ecologically valid and low-burden method for fatigue assessment. Speech analysis tools offer promising potential applications in clinical practice for improving disease monitoring and management.
Trends and development in perioperative enteral nutrition: a systematic bibliometric analysis
Authors: Luo Chen , Yin Jianing , Sha Yuejiao , Gong Wei , Shen Ling
Published: September 2024

Background

This research aims to explore the intellectual landscape of studies in perioperative enteral nutrition (PEN) and identify trends and research frontiers in the field.

Methods

Scientometric research was conducted through the analysis of bibliographic records from the Web of Science Core Collection Database for the period 2014–2023. Analyses performed using CiteSpace software included cooperation network analysis, reference co-citation analysis, and keywords co-occurrence analysis.

Results

The analysis included 3,671 valid records in the final dataset. Findings indicate an upward trend in annual publications, with the United States leading in research output and Harvard University as the top publishing institution. The Journal of Parenteral and Enteral Nutrition was identified as the most productive journal. Notable research hotspots include enhanced recovery after surgery, early enteral nutrition, intestinal failure, short bowel syndrome, abdominal surgery. Evidence-based articles have emerged as the predominant literature type. Future research trends are anticipated to focus on gut microbiota and patients with congenital heart disease.

Conclusion

Our study provides a comprehensive analysis of the publication volume, contributions by country/region and institutions, journal outlets, and reference and keyword clusters in the field of PEN over the decade. The findings provide valuable insights for researchers, policymakers, and clinicians, helping them comprehend the research landscape, identify gaps, and shape future research directions in this field.
Effect of different harvest times and processing methods on the vitamin content of Leymus
Authors: Wang Yifan , Chen Xue , Zhuo Xingliang , Wang Lei , Jia Tingting , Ji Fangcai , Zhang Hongrui , Yu Zhu
Published: September 2024

Objectives

The objective of this study was to investigate the effect of different harvest times and processing methods on the B vitamins and α-tocopherol contents of Leymus chinensis (Trin.).

Methods

L. chinensis was harvested on 11 July (T1 group), 16 July (T2 group), 21 July (T3 group), 26 July (T4 group), and 31 July (T5 group) in 2022 and processed using natural drying and silage fermentation to evaluate fermentation quality, chemical composition, in vitro digestibility and vitamin content.

Results

The fermentation quality of L. chinensis silage prepared at all five times of harvest was better. The silage fermentation group showed a significant increase (p < 0.05) in crude protein (CP), thiamin, riboflavin, pyridoxine and α-tocopherol content, a significant decrease (p < 0.05) in water-soluble carbohydrate (WSC) content, and small differences in neutral detergent fibre (NDF), acid detergent fibre (ADF), niacin and pantothenic acid content, when compared to the natural drying group. The content of thiamine, riboflavin, niacin, pantothenic acid and pyridoxine were higher in the pre-harvest period. In silage fermentation, the loss rate of thiamin, riboflavin and pyridoxine was positively correlated with pH and WSC, and the loss rate of thiamin and riboflavin was negatively correlated with lactic acid content. The loss rate of pantothenic acid was negatively correlated with pH and WSC, and positively correlated with lactic acid and ammonia nitrogen. The rate of α-tocopherol synthesis exceeded the rate of catabolism.

Conclusion

The content of CP, thiamine, riboflavin, niacin, pantothenic acid and pyridoxine were higher during the early harvest period. Silage fermentation preserved the chemical composition and vitamin content of L. chinensis better than natural drying and had no effect on in vitro digestibility. During silage fermentation, the acidic environment promoted the preservation of thiamin, riboflavin and pyridoxine, but promoted the breakdown of pantothenic acid, α-tocopherol content increased through synthesis.
Assessing the impact of dietary choices on fiber deficiency: insights from the 2017–2020 Polish national adult nutrition survey
Authors: Kucharska Alicja , Sińska Beata Irena , Panczyk Mariusz , Samel-Kowalik Piotr , Szostak-Węgierek Dorota , Raciborski Filip , Samoliński Bolesław , Traczyk Iwona
Published: September 2024

Introduction

Dietary fiber is a key component of a healthy diet, associated with a reduced risk of cardiovascular disease, obesity, type 2 diabetes, certain cancers, chronic inflammation, or depression. The aim of the study was to perform an in-depth analysis of dietary fiber intake in the Polish population, taking account of the consumption of groups of products that are fiber sources and identify any age-related differences in the dietary fiber intake of the subjects.

Methods

We analyzed data obtained from two representative cross-sectional studies on the diet and nutritional status of adult Polish residents including the total of 4,000 individuals aged 19 years and more. Two 24-h recalls were used per individual to assess the diet using the computer-assisted personal interview (CAPI) technique. Total fiber content and fiber contained in cereal products, vegetables, fruits, legumes, nuts and seeds were calculated. Fiber intake was compared to the recommendations: 25 g/d for adults up to 65 years of age and 20 g/d for those aged 66 years and older. All statistical analyses, including the Pearson’s chi-squared test, the Student’s t-test, and the Analysis of Variance (ANOVA), were conducted using STATISTICA™ version 13.3, with the results being adjusted for demographic distribution biases to enhance the representativeness.

Results

The average daily fiber intake was 17.83 ± 0.14 g/day (78% of the recommended intake), with 20.5% of respondents meeting the requirement. More men than women (27.05% vs. 14.3%;) met the requirement and men were characterized by a higher average intake (19.34 ± 0.20 g/day) than women (16.43 ± 0.19 g/day). The main fiber sources were cereals (44.1%), vegetables (23.6%), and fruits (16.0%). As regards men, the sources included refined bread (25.8%), vegetables (23.1%), and fruits (10.2%) and for women, they were vegetables (24.0%), fruits (17.2%), and refined bread (16.3%). Although refined bread is not recommended as a primary fiber source due to its lower fiber content compared to whole grain bread, its high consumption significantly contributed to the total fiber intake.

Conclusion

The prevalence of widespread dietary fiber deficiency calls for the intensification of educational efforts that address the health advantages and sources of dietary fiber, as well as methods for its inclusion in daily meals.
Analysis of dietary inflammatory potential and mortality in cancer survivors using NHANES data
Authors: Wu Yemei , Yi Jing , Zhang Qu
Published: September 2024

Background

In the United States, cancer is a leading cause of mortality, with inflammation playing a crucial role in cancer progression and prognosis. Diet, with its capacity to modulate inflammatory responses, represents a potentially modifiable risk factor in cancer outcomes.

Methods

This study utilized data from the National Health and Nutrition Examination Survey (NHANES, 1999–2018) to investigate the association between the Dietary Inflammatory Index (DII), which reflects dietary-induced inflammation, and mortality among cancer survivors. A total of 3,011 participants diagnosed with cancer were included, with DII scores derived from dietary recall data. All-cause and cancer-related mortalities served as primary endpoints.

Results

The study identified a significant linear positive correlation between higher DII scores and all-cause mortality among cancer survivors. Each unit increase in DII was associated with a 10% higher risk of all-cause mortality (hazard ratio [HR] per 1-unit increase, 1.10; 95% confidence interval [CI], 1.04–1.15). Similarly, a unit increase in DII was associated with a 13% higher risk of cancer-related mortality (HR per 1-unit increase, 1.13; 95% CI, 1.02–1.25). Kaplan–Meier analyses demonstrated higher all-cause mortality rates in individuals with elevated DII scores. Sensitivity analyses confirmed the robustness of these findings.

Conclusion

Adoption of an anti-inflammatory diet, characterized by lower DII scores, may improve survival outcomes in cancer survivors. These results emphasize the critical role of dietary interventions in post-cancer care.
Role of CT imaging in addressing resectability issues in differentiated thyroid cancer: imaging-based Mahajan grading system for TI and ETE
Authors: Mahajan Abhishek , Rastogi Shivam , Shukla Shreya , Agarwal Ujjwal , Vaish Richa , Chakrabarty Nivedita , Ashtekar Renuka , Deokar Shonal , Shaikh Atif , Pai Prathamesh , Chaturvedi Pankaj , Ghosh Laskar Sarbani , Smriti Vasundhara , Rane Swapnil U. , Bal Munita , Patil Asawari , Mittal Neha , Noronha Vanita , Patil Vijay , Prabhash Kumar , Dcruz Anil K.
Published: September 2024

Background and objective

Extrathyroidal extension (ETE) is the term used to describe the growth of the primary thyroid tumor beyond the thyroid capsule. ETE is a critical prognostic marker for thyroid tumors, necessitating accurate preoperative assessment. This study aims to evaluate the diagnostic performance of computed tomography (CT)-based grading for ETE and tracheal invasion (TI) for preoperative prediction in patients with differentiated papillary thyroid carcinoma (PTC) and compare the diagnostic accuracy with ultrasound (US).

Materials and methods

This retrospective study was approved by our institutional review board. Preoperative US and CT were performed for 83 patients who underwent surgery for PTC between 1 January 2010 and 31 December 2020. The US and CT features of ETE and TI of each case were retrospectively and independently investigated by two radiologists. The diagnostic performances of US and CT, including their specificity, sensitivity, positive predictive value (PPV), and negative predictive value (NPV) for ETE, and their accuracy in predicting ETE and TI were analyzed. As per the grading for ETE on USG and CT, lesions were graded into three grades and Mahajan grading was also devised on CT to predict the TI and graded into four grades.

Results

The accuracy and specificity of CT are relatively good for identifying tumor infiltration into the adjacent structures and range from 82% to 87% and 95% to 98%, respectively. It, however, has a low sensitivity, between 14.3% and 77.78%, when compared to US, which suggests that in case of any doubt regarding CT evidence of tumor infiltration into surrounding structures, additional clinical examination must be performed. CT showed better sensitivity (78%) and specificity (75%) in detecting TI compared to previous studies. The diagnostic accuracy of CT Mahajan grading was 91.5% with p <0.005 in the prediction of TI.

Conclusion

Preoperative US should be regarded as a first-line imaging modality for predicting minimal ETE, and CT should be additionally performed for the evaluation of maximal ETE. The specificity and PPV of CT are higher than those of US in detecting overall ETE and TI of PTC. The US- and CT-based grading systems have the potential to optimize preoperative surgical planning.
USP7 regulates growth and maintains the stemness of p53-mutant colorectal cancer cells via stabilizing of mutant p53
Authors: Li Xue , Pan Jie , Zheng Pengcheng
Published: September 2024

Introduction

TP53 is one of the most frequently mutated genes among all cancers, and TP53 mutants occur more than 40% in colorectal cancers (CRCs). Accumulation of mutant p53 may augment colorectal cancer stem cells (CCSCs) phenotype and enhance colorectal tumorigenesis. Thus, reducing the level of mutant p53 protein is an attractive anticancer strategy.

Methods

CSC-enriched cancer cells were obtained by tumor sphere formation assay. The effects of USP7 on the proliferation of cancer cells were determined by MTS and colony formation assays. Wound healing assay was used to test cell migratory abilities. qPCR and western blotting assays were performed to verify the mRNA and protein levels of CSC markers, USP7 and p53. Co-immunoprecipitation assay was used to test the interaction effects between USP7 and p53.

Results

In this study, we found that USP7 and mutant p53 were dramatically elevated in CSC-enriched colorectal cancer cells and USP7 expression was positively associated with self-renewal and maintenance of CCSCs. USP7 regulated cell growth, stemness and migration of colorectal cancer cells. USP7 depletion significantly reduced proliferation of cancer cells and suppressed the self-renewal of CSC-enriched colorectal cancer cells. Further studies indicated that USP7 knockdown could significantly decrease mutant p53 protein levels both in CRCs and CSC-enriched colorectal cancer cells. Moreover, mutant p53 was stabilized by USP7 and they interacted with each other. Furthermore, USP7 inhibitor P5091 also diminished CCSCs self-renewal and reduced mutant p53 levels.

Conclusion

Taken together, our findings demonstrated that USP7 involved in the modulation of CCSCs stemness, as well as a critical target for clinical treatment of cancers with different p53 mutations.
Cleft lip and palate transmembrane protein 1-like is a putative regulator of tumorigenesis and sensitization of cervical cancer cells to cisplatin
Authors: Liu Weipeng , Huang Fengdan , Yao Yueting , Liang Yan , Yan Zhiling , Guo Lili , Zhang Xinwen , Shi Li , Yao Yufeng
Published: September 2024

Background

Cervical cancer stands as one of the leading causes of cancer-related mortality in women worldwide, yet the precise functions of host genes implicated in its pathogenesis remain elusive. Genome-wide association studies (GWAS) have revealed a significant association between the CLPTM1L locus and cervical cancer risk in European women, and aberrant expression of CLPTM1L has been noted in various malignant tumors. However, the role of CLPTM1L in cervical cancer remains largely unexplored.

Methods

The expression of CLPTM1L in cervical cancer cells and tissues was detected by RT-qPCR. Furthermore, the potential biological functions of CLPTM1L in the context of cervical cancer were explored via RNA sequencing. Cell proliferation rates and the responsiveness of cervical cancer cells to cisplatin were evaluated using the CCK-8 assay, while cell apoptosis was quantified through the utilization of flow cytometry. Nude mouse xenograft models were utilized to explore the impact of CLPTM1L on tumor formation in vivo.

Results

Our findings demonstrated a significant increase in CLPTM1L mRNA expression levels in HeLa and C33A cells, as well as in cervical carcinoma tissues, compared to ECT1/E6E7 cells and adjacent normal tissues. Genes related to CLPTM1L were found to be enriched in the Hedgehog signaling pathway. In vitro and in vivo studies showed that reducing CLPTM1L expression markedly inhibited cell proliferation via downstream candidate genes BOC and LRP2. Furthermore, the downregulation of CLPTM1L was found to enhance cisplatin-induced cell apoptosis and increase the susceptibility of cervical cancer cells to cisplatin through DAP1.

Conclusions

CLPTM1L could impact cervical cancer cell proliferation and cisplatin-induced cell apoptosis, as well as cisplatin susceptibility in cervical cancer cells. This investigation has bestowed upon us novel insights into the pathogenesis of cervical cancer, underscoring the potential of CLPTM1L as a promising target for chemotherapeutic sensitization in the management of this malignancy.
Research trends on chemotherapy induced nausea and vomiting: a bibliometric analysis
Authors: Ning Chunhui , Yan Yunzi , Wang Yansong , Li Rui , Liu Wenjie , Qiu Linjie , Sun Lingyun , Yang Yufei
Published: September 2024

Background

CINV is a frequent adverse response to cancer treatment. There is still much to learn about the pathophysiology and initiating event of CINV, which necessitates continued research despite decades of effort. Identifying the current foci of the complex disease and assessing the scientific impact of pertinent study are made more difficult by the abundance of publications on CINV. Therefore, our goals in this article are to evaluate developments in this field, examine patterns in research domains, and gauge the expansion of CINV research production globally.

Methods

Articles about CINV published between 2012 and 2022 were found by searching the Web of Science Core Collection of Clarivate Analytics. The number of publications over time was visualized using Microsoft Office Excel 2019. CiteSpace and VOSviewer were utilized to create knowledge maps that analyzed collaborations between nations, organizations, and writers. They also presented the history of CINV research and highlighted its current areas of focus.

Results

In this study, 846 papers in all were assessed. Most publications (237, 28.01%) came from the United States. University of Toronto was the most productive institution (34, 4.01%). With 25 articles published, or 2.96% of the total, Aapro Matti published the most. The most frequently published journal was found to be Supportive Care (158, 18.68%). “Palonosetron,” “Moderately emetogenic chemotherapy,” “5-HT3 receptor antagonist,” and “Neurokinin 1 receptor antagonists” were considered the hot topics. It can be seen that the research focus is on the drug treatment of chemotherapy-induced nausea and vomiting.

Conclusion

Through bibliometric analysis, we were able to gain profound insights into CINV research for the first time. Researchers looking to uncover research frontiers and comprehend important information in this discipline may find the study’s findings useful.
Exploring medication self-management in polypharmacy: a qualitative systematic review of patients and healthcare providers perspectives
Authors: Jin Ran , Liu Caiyan , Chen Jinghao , Cui Mengjiao , Xu Bo , Yuan Ping , Chen Lu
Published: September 2024

Purpose: Polypharmacy presents many challenges to patient medication self-management. This study aims to explore the self-management processes of medication in polypharmacy from the perspectives of both patients and healthcare providers, which can help identify barriers and facilitators to effective management.

Methods: A systematic review of qualitative studies was performed by searching seven databases: PubMed, Web of Science, Cochrane Library, Embase, CINAHL, PsycINFO, and MEDLINE, from their establishment until August 2024. The Critical Appraisal Skills Programme (CASP) tool was employed to evaluate the quality of the studies included. The extracted data were then analysed thematically and integrated into The Taxonomy of Everyday Self-management Strategies (TEDSS) framework.

Results: A total of 16 studies were included, involving 403 patients and 119 healthcare providers. Patient management measures were mapped into TEDSS framework, including categories such as medical management, support-oriented domains, and emotional and role management.

Conclusion: Enhancing patients’ proactive health awareness, improving medication literacy, balancing lifestyle adjustments with medication therapy, dynamically reviewing and optimizing medications, strengthening patients’ social support networks, and helping patients integrate medication management into their daily life are the key elements that can effectively assist patients in self-managing their medications. Future interventions to improve patient medication self-management ability should be designed for these issues.

Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024524742.
Contemporary applications of vibrational spectroscopy in plant stresses and phenotyping
Authors: Juárez Isaac D. , Kurouski Dmitry
Published: September 2024

Plant pathogens, including viruses, bacteria, and fungi, cause massive crop losses around the world. Abiotic stresses, such as drought, salinity and nutritional deficiencies are even more detrimental. Timely diagnostics of plant diseases and abiotic stresses can be used to provide site- and doze-specific treatment of plants. In addition to the direct economic impact, this “smart agriculture” can help minimizing the effect of farming on the environment. Mounting evidence demonstrates that vibrational spectroscopy, which includes Raman (RS) and infrared spectroscopies (IR), can be used to detect and identify biotic and abiotic stresses in plants. These findings indicate that RS and IR can be used for in-field surveillance of the plant health. Surface-enhanced RS (SERS) has also been used for direct detection of plant stressors, offering advantages over traditional spectroscopies. Finally, all three of these technologies have applications in phenotyping and studying composition of crops. Such non-invasive, non-destructive, and chemical-free diagnostics is set to revolutionize crop agriculture globally. This review critically discusses the most recent findings of RS-based sensing of biotic and abiotic stresses, as well as the use of RS for nutritional analysis of foods.
Optimizing daylily (Hemerocallis citrina Baroni) cultivation: integrating physiological modeling and planting patterns for enhanced yield and resource efficiency
Authors: Li Weijia , Zhang Kun , Liu Jianxia , Wu Juan , Zhang Yue , Henke Michael
Published: September 2024

Introduction

Optimizing the dynamics of daylily (Hemerocallis citrina Baroni) growth under various planting patterns is critical for enhancing production efficiency. This study presents a comprehensive model to simulate daylily growth and optimize planting patterns to maximize bud yield while minimizing land resource utilization.

Methods

The model incorporates source-sink relationship specific to daylilies into physiological process modeling, considering environmental factors such as micro-light and temperature climate, and CO2 concentration. Spatial factors, including planting pattern, row spacing, plant spacing, and plant density were examined for their impact on light interception, photosynthesis, and resource efficiency. Employing partial least square path modeling (PLS-PM), we analyzed the interrelations and causal relationships between planting configurations and physiological traits of daylily canopy leaves and buds. Through in situ simulations of 36 planting scenarios, we identified an optimal configuration (Scenario ID5) with a density of 83,000 plants·ha−1, row spacing of 0.8 m, and equidistant planting with a plant spacing of 0.15 m.

Results and discussion

Our research findings indicate that increased Wide+Narrow row spacing can enhance yield to a certain extent. Although planting patterns influence daylily yield, their overall impact is relatively minor, and there is no clear pattern regarding the impact of plant spacing on individual plant yield. This modeling approach provides valuable insights into daylily plant growth dynamics and planting patterns optimization, offering practical guidance for both farmers and policymakers to enhance daylily productivity while minimizing land use.
Adaptations to family-based treatment for Medicaid-insured adolescents with anorexia nervosa
Authors: Borges Renee , Crest Peyton , Landsverk John , Accurso Erin C.
Published: September 2024

Background

Family-based treatment (FBT) is the leading intervention for adolescents with anorexia nervosa (AN); however, it is under researched in socioeconomically disadvantaged and racially diverse youth.

Methods

Semi-structured interviews were completed with ten FBT clinicians who practice in publicly-funded settings. Interview questions were focused on implementation challenges, overall acceptability and appropriateness of FBT, and naturally-occurring treatment adaptations.

Results

Content analysis revealed common themes relating to the implementation of FBT in publicly-funded, community-based settings: acceptability and appropriateness, complexity and learnability, perceived core components of FBT, cultural adaptations, socioeconomic factors, logistical considerations, organizational and systemic barriers, training acceptability, participant’s self-efficacy, and telehealth accommodations.

Conclusion

The discussed themes offer insights into the implementation of FBT for settings with limited resources, aligning with prior research on clinical adaptations for multicultural patients. Recognizing these themes can guide clinical adjustments and refine the adapted treatment model in real-world settings for patients facing systemic barriers.
Enhancing nutritional knowledge and self-regulation among adolescents: efficacy of a multifaceted food literacy intervention
Authors: Mancone Stefania , Corrado Stefano , Tosti Beatrice , Spica Giuseppe , Di Siena Francesco , Misiti Francesco , Diotaiuti Pierluigi
Published: September 2024

This health literacy intervention study, conducted on adolescent students, aimed to evaluate the impact of a comprehensive educational program on promoting healthy eating habits. The intervention sought to enhance adolescents’ knowledge about nutrition, foster self-regulation skills, and ultimately improve their overall health, including their body mass index (BMI). Through a multi-component approach that combined theoretical learning with practical activities and the integration of digital tools such as the MyFitnessPal app, the study targeted improvements in food literacy, which encompasses nutrition knowledge, food label interpretation skills, and cooking abilities. These elements are critical in influencing adolescents’ food choices and eating behaviors, with a focus on increasing the consumption of fruits and vegetables while reducing the intake of fast food and processed snacks. The intervention was structured around a series of educational workshops and interactive sessions, facilitated by professionals experienced in nutrition. These sessions covered topics such as food composition, the importance of a balanced diet, and strategies for avoiding excessive consumption of processed and high-energy-density foods. A distinctive feature of the program was its use of digital tools to enhance engagement and allow for the practical application of learned concepts through food tracking and activity monitoring. Preliminary results indicate positive outcomes in terms of increased food knowledge and improved dietary habits among participants. Notably, there was a significant improvement in adolescents’ BMI, highlighting the potential of food literacy interventions to contribute to better physical health outcomes. The study underscores the importance of adopting multidisciplinary and technology-enhanced approaches in educational programs aimed at promoting healthy eating among adolescents. The study’s findings suggest that well-structured food education programs, tailored to address the specific needs of adolescents, can facilitate positive changes in eating behavior. This highlights the critical role of food literacy in adolescents’ health and wellbeing and points to the need for continued investment in research and development to optimize intervention strategies. The integration of digital technologies and a focus on self-regulation strategies are identified as promising avenues for future research and educational practice, reinforcing the call for innovative investments in food education and health promotion among the youth.
Minding the gap: a sex difference in young infants’ mental rotation through thirty degrees of arc
Authors: Moore David S. , Moore Dawn Michele , Johnson Scott P.
Published: September 2024

Mental rotation (MR) is an important feature of spatial cognition invoking mental imagery of an object’s appearance when viewed from a new orientation. Prior studies have revealed evidence of MR in infants, including a sex difference similar to that detected in older populations. Some of these studies used visual habituation methods whereby infants were familiarized with an object rotating through a 240° angle, followed by test trials showing either the habituation object or a mirror image object rotating through the previously unseen 120° angle. Significantly longer looking at either of these objects was taken to reflect infants’ ability to recognize the habituation object even when seen from a novel viewpoint, suggesting the capacity for MR. However, these infants’ responses could, in theory, be explained with reference to perceptual discrimination rather than MR, because the views of the habituation and test objects were very similar in some video frames. In the current study, we observed a diverse population of 5-month-olds (24 females, 24 males) for evidence of MR through 30° of arc. In this more challenging test, our stimuli left a 30° gap angle between critical video frames representing the habituation and test objects. Consistent with earlier reports, we found that relative to female infants, male infants looked significantly longer at the mirror image test stimulus immediately following habituation. These results add to an emerging consensus that some young infants are capable of MR, and that male and female infants on average behave differently in this type of MR task.
Breaking the cycle with trauma-focused mentalization-based treatment: theory and practice of a trauma-focused group intervention
Authors: Smits Maaike L. , de Vos Jasmijn , Rüfenacht Eva , Nijssens Liesbet , Shaverin Lisa , Nolte Tobias , Luyten Patrick , Fonagy Peter , Bateman Anthony
Published: September 2024

Trauma-Focused mentalization-based treatment (MBT-TF) is an adaptation of mentalization-based treatment (MBT) specifically developed for patients suffering from attachment or complex trauma, with the possibility of co-occurring borderline personality pathology. The creation of MBT-TF was driven by previous research and observations that interventions centered on mentalizing could be significantly improved by directly addressing the impact of trauma. MBT-TF aims to mitigate symptoms that arise post-trauma, such as hyperarousal, hypervigilance, intrusions, flashbacks, avoidance behaviors, dissociative experiences, negative perceptions of self and others, and ensuing relational difficulties. Implemented as a group intervention, MBT-TF typically spans 6–12 months. From a mentalizing perspective, trauma, particularly attachment trauma, leads to a failure in processing the effects of trauma through and with others. Stress and attachment behavioral systems are disrupted, which undermines the capacity for epistemic trust, and impairs mentalizing abilities. This paper offers a concise summary of the reasoning for MBT-TF’s creation, its theoretical underpinnings, and its clinical strategy for addressing the adverse impacts of trauma. It further details the treatment phases, their main goals, and their interventions, supplemented by clinical case examples that underscore MBT-TF’s distinctive attributes and frequent clinical hurdles.
How to improve emotional regulation in breast cancer survivors? A psychological intervention
Authors: Sebri Valeria , Policardo Giulia Rosa , Pravettoni Gabriella
Published: September 2024

Objective

Psychological interventions are pivotal in enhancing the Quality of Life for breast cancer survivors, with a primary focus on addressing affective and cognitive challenges through group discussions among those diagnosed with the disease. While the influence of Body Image on overall well-being is well-documented, research on interventions specifically designed to address Body Image concerns in this demographic remains scarce. The present study aimed to fill this gap by evaluating the outcomes of a psychological intervention focused on fostering a positive Body Image among 25 breast cancer survivors.

Method

Participants were divided into an experimental group, which received the intervention (n = 13), and a control group that did not receive any psychological support (n = 12).

Results

Our findings highlight significant disparities in emotional regulation strategies, specifically cognitive reappraisal and expressive suppression, with the intervention group reporting enhanced emotional regulation. Contrary to initial hypotheses, the analysis unveiled statistically significant differences in both negative (social physique anxiety) and positive (functionality appreciation) body image dimensions, indicating elevated levels of social physique anxiety and reduced functionality appreciation among intervention participants.

Conclusion

The total results may suggest that the intervention, while effective in enhancing emotional regulation, heightened awareness of body image issues, leading to increased social physique anxiety and diminished functionality appreciation. The paper further discusses practical implications arising from these insights.
Psychological capital and music performance anxiety: the mediating role of self-esteem and flow experience
Authors: Jiang Xin , Tong Yanli
Published: September 2024

Background

This study aimed to explore the correlation between psychological capital and music performance anxiety among Chinese college students majoring in music. Additionally, the study evaluated the chain mediating effects of self-esteem and flow experience.

Methods

Three hundred twenty-nine college students pursuing a music major from institutions in Eastern China participated in the study. They were asked to complete the Psychological Capital, Self-Esteem, Flow Experience, and Music Performance Anxiety Scales. Descriptive statistics and correlation analysis were performed, and sophisticated mediation models were created.

Results

The results suggest that self-esteem and flow experience play a role in connecting psychological capital and music performance anxiety. Moreover, the ultimate model elucidates significant connections linking psychological capital to self-esteem and flow experience in music performance anxiety.

Conclusion

This study offers useful insights for future interventions aimed at mitigating music performance anxiety through the cultivation of students’ psychological capital, self-esteem, and flow experiences.
Impact of exercise type, duration, and intensity on depressive symptoms in older adults: a systematic review and meta-analysis
Authors: Li Xinglu , He Shaokai , Liu Tao , Zhang Xinxin , Zhu Wenfei , Wang Chao , Sun Yuliang
Published: September 2024

Objective

This systematic review and meta-analysis assessed the effects of three types of physical exercise (resistance exercise, aerobic exercise, and group exercise), different exercise intervention times (3 months, 6 months), and different exercise intensities (low, moderate, and high) on the improvement of depressive symptoms in older adults aged ≥60 years, as well as to explore the impact of the sustainability of these physical exercise intervention programs on depressive symptoms in older adults.

Methods

The randomized controlled trials (RCTs) on the effect of physical exercise on depressive symptoms in older adults were retrieved from Cochrane Library, Web of Science, PubMed, and Embase Data. The retrieval time limit is from establishing the database to January 7, 2024. We conducted a meta-analysis using a 95% confidence interval (95% CI) and the standardized mean differences (SMD). The I2 statistic was used to assess the heterogeneity of the outcomes of the studies. When I2 < 50%, we used the fixed-effects model, and when I2 > 50%, we used the random-effects model. Subgroup and sensitivity analyses investigated heterogeneity origins.

Results

There are 15 articles reported 20 studies, with a total of 1,346 patients, including 689 in the control group and 657 in the experimental group. The findings demonstrated a notable improvement in depression symptoms among older persons as an immediate result of engaging in physical exercise [SMD = −0.82, 95% CI (−1.19, −0.45)]. The subgroup analysis showed that moderate-intensity physical exercise [SMD = −0.25, 95% CI (−0.47, −0.03)], high-intensity physical exercise [SMD = −0.94, 95% CI (−1.37, −0.51)], resistance exercise [SMD = −0.70, 95% CI (−1.20, −0.20)], and group exercise [SMD = −0.97, 95% CI (−1.89, −0.05)], and the exercise intervention time was 3 months [SMD = −0.81, 95% CI (−1.38, −0.23)] or 6 months [SMD = −0.93, 95% CI (−1.46, −0.41)] were more effective in improving depressive symptoms in older adults.

Conclusion

The sustainable resistance and group exercise have a better effect on improving depressive symptoms in older adults. Appropriate exercise intervention time can also ensure the sustainable improvement effect of exercise.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/record_email.php, identifier CRD42023405525.
Unraveling the spectrum: overlap, distinctions, and nuances of ADHD and ASD in children
Authors: Martinez Sabrina , Stoyanov Kalin , Carcache Luis
Published: September 2024

This review explores the clinical presentation of similarities and differences in Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). This paper investigates the deficits in executive function, social function, and emotional intelligence that are seen in both conditions and how the presence of both conditions can exacerbate these deficiencies. Understanding the clinical presentations in these domains is critical to refine diagnostic methods and treatments and improve outcomes for those affected by these neurodevelopmental disorders. The similarities in clinical presentation between ADHD and ASD present a significant diagnostic challenge, with individuals often exhibiting similar behaviors and difficulty navigating the complexities that encompass reacting to their environment. Further research is paramount in gaining more knowledge of the disorders and challenges faced by these individuals, especially those with the presence of both conditions.