bluuebunny/crossref_metadata_2025 huggingface dataset:
EOR Returned Polymer Removal from Produced Water by Chemical Coagulation – A Successful Pilot Testing
Authors: Zagitov Robert , Subramanian Jaisankar , Gopisetty Srinivasa Rao , Kumar Avinash , Mathur Vinay , Venkat Panneer Selvam , Mehta Dharmesh
Published: December 2021

Severe fouling of crude oil and produced water treatment equipment of Mangala Processing Terminal (MPT) with elastic deposits has been observed after EOR polymer breaking through to the producing wells. Fouling by polymer containing solids caused the system bottlenecking impacting on crude production rates and deterioration of water quality for injection due to increase of total solids loading.

The objective of the study included developing the water treatment technology for removing the returned polymer, developing the pilot run for implementation of the technology and scaling up the process if the pilot shows success.

Crude processed at MPT is produced from Mangala, Bhagyam and Aishwarya fields which are located at the north-west part of India. Full field polymer flooding has been implemented in the Mangala field from 2015. Fouling of downhole and topside equipment with elastic deposits has been reported soon after polymer breakthrough the same year.

For reducing the fouling potential and solids loading, the concept of removing the returned polymer from produced water has been considered as beneficial.

Removal of polymer through the chemical coagulation was considered for developing. Extensive laboratory and bench testing have been carried out. Based on the laboratory results, the pilot was developed and carried out on the flotation equipment available at MPT.

In the laboratory and bench test for polymer coagulation, over 70% polymer removal was achieved with non-sticky flocks and minimal sludge. The tests also demonstrated reduced suspended solids, residual oil and filterability improvement of treated water.

The pilot run confirmed effectiveness of the chemical coagulation process to remove polymer. Polymer removal > 70% was observed during the pilot. Oil removal from produced water at 60-80% was seen. Cloud point of polymer remaining in water increased from 60°C to > 110°C indicating on the significant potential reduction of remaining polymer to precipitate from treated water.

The pilot results demonstrated on the applicability of the technology of chemical polymer removal at MPT and will be used for scaling up the treatment facilities.
Butterfly Glioblastoma - the Impact of Tumor Volumes and Treatment Strategies on Clinical Outcome
Authors: Bjorland Line Sagerup , Kurz Kathinka Dæhli , Fluge Fluge Øystein , Gilje Bjørnar , Mahesparan Rupavathana , Sætran Hege , Ushakova Anastasia , Farbu Elisabeth
Published: December 2021

PurposeButterfly glioblastoma is a rare subgroup of glioblastoma with a bihemispheric tumor crossing the corpus callosum, and is associated with a dismal prognosis. Prognostic factors are previously sparsely described and optimal treatment approaches remain uncertain. We aimed to analyse prognostic factors in butterfly glioblastoma, and to evaluate treatment strategies and outcome in a real-world setting.MethodsWe conducted a retrospective population-based cohort study of patients diagnosed with butterfly glioblastoma in Western Norway between 01/01/2007 and 31/12/2014. Clinical data were extracted from electronic medical records. Molecular and MRI volumetric analyses were retrospectively performed. Survival analyses were performed using Kaplan-Meier method and Cox proportional hazards regression models.ResultsAmong 381 patients diagnosed with glioblastoma, 33 patients (8.7%) met the criteria for butterfly glioblastoma. Median overall survival was 5.5 months (95% CI 3.1-7.9) and three-year survival was 9.1%. Older age and mainly deep-seated tumour location were associated with poor outcome, with adjusted hazard ratio (HR) 1.06 (95% CI 1.03-1.10), p<0.001, and adjusted HR 4.58 (95% CI 1.15-18.20), p=0.03. Best supportive care was associated with poorer survival compared to multimodal treatment (adjusted HR 5.11 (95% CI 1.09-23.89), p=0.04).ConclusionOutcome from butterfly glioblastoma was dismal, with a median overall survival of less than six months. However, long-term survival was comparable to that observed in glioblastoma in general, and multimodal treatment was associated with longer survival. This suggests that patients with butterfly glioblastoma may benefit from a more comprehensive treatment approach despite the overall poor prognosis.
Characterization and Classification of Soils and Water in Major Irrigated Lands of Lake Abaya Chamo Basin.
Authors: Gelu Gezimu , ayza alemnesh gelu gezimu , dane Chanako
Published: December 2021

Large amount of irrigated land under Lake Abaya Chamo basin is becoming unproductive every year because of salinity and sodicity expansion; consequently farmers are leaving their land out of cultivation due to burning of crops. For sustainable land use and Agricultural water management, it is a very important to examine the chemical composition of soils water and status of their quality. Therefore, the study was aimed to evaluate the physico-chemical properties of soils and irrigation water of irrigated lands under Lake Abaya Chamo basin, located in South East rift valley of Ethiopia. The pH of the soil in the study area ranged from (7.24 to 9.04, 7.54 to 7.91), Electrical conductivity (0.388 to 19.22, 0.644 to 23.6) under Lake Abaya and Chamo, respectively. The results of irrigation water quality showed that the water class of lake Abaya Chamo basin is under harzard status of salinity and sodicity and cannot be recommended for irrigation use. There is a potential danger of sodicity and salinity development in the intended lake basin. Thus, selection of salinity and sodicity resistant crop types, proper irrigation water application methods and other chemical mitigation measures should be designed for sustainability of soil and water productivity.
Dental Pulp Mesenchymal Stem Cells Promote Polarization of M2 Macrophages and Accelerate Wound Healing by Secreting CCL2
Authors: Yang Zi , Ma Linsha , Du Congling , Wang Jinsong , Zhang Chunmei , Hu Lei , Wang Songlin
Published: December 2021

Background
Mesenchymal stem cells (MSCs) are widely used in tissue engineering owing to their regenerative potential and immunomodulatory capacity. The crosstalk between MSCs and the host immune function plays a key role in the efficiency of tissue regeneration. However, the difference in immunological modulation and tissue regeneration function between MSCs from different sources remains unclear.
Methods
Human mesenchymal stem cells derived from bone marrow (BMMSCs), periodontal ligament (PDLSCs), adipose (ADSCs), and dental pulp (DPSCs) were obtained and induced to form cell sheets under the condition of 20 ug/ml vitamin C. The MSC cell sheets carried by hydroxyapatite/tricalciumphosphate (HA/TCP) particles were transplanted subcutaneously into C57BL6 mice for 8 weeks. Histological analyses were performed to detect the tissue regeneration potential and macrophages polarization in vivo. Then, THP-1 macrophages were co-cultured with MSCs and quantitative real-time polymerase chain reaction, immunofluorescent staining, western blotting, and enzyme-linked immunosorbent assay were used to investigate the function and mechanism of MSCs on macrophages in vitro. Finally, a wound healing model of the palatal mucosa was performed to confirm the effect of MSCs on macrophages and tissue healing efficiency.
Results
Compared to PDLSCs, BMMSCs, and ADSCs, DPSCs exhibited greater tissue regeneration potential, with greater tissue volume, higher Ki67 expression, and less apoptosis in the regenerated tissue of wild-type C57BL6 mice. In addition, DSPCs triggered more M2 macrophages in the regenerated tissue than other MSCs. Our data showed that DPSCs exhibited higher expression levels of C-C Motif Chemokine Ligand 2 (CCL2), and specific blocking of CCL2 by neutralising antibodies can significantly inhibit the DPSCs-induced polarization of M2 macrophages. Finally, DPSCs transplantation promoted wound healing of the palatal mucosa and M2 macrophages polarization in vivo, which could be significantly impaired by CCL2 neutralising antibody.
Conclusions
Our data indicate that DPSCs exert better tissue regeneration potential and immunoregulatory function by secreting CCL2. These results suggest that CCL2 application can enhance MSC-mediated tissue regeneration or wound healing.
The Alcohol Flushing Response is Associated with the Risk of Depression
Authors: Jeon Seonghee , Kang Heewon , Cho Inhyung , Cho Sung-il
Published: December 2021

The alcohol flushing response is experienced by 36–45% of East Asians after drinking a small amount of alcohol. Since individuals with this response are incapable of metabolizing toxic acetaldehyde derived from alcohol effectively, this response is suggested as an indicator for the health risks associated with alcohol intake. Depression, a major health problem linked to alcohol consumption, might also be associated with the presence of the alcohol flushing response. Therefore, this study examined the association between the alcohol flushing response and the risk of depression in the general population of South Koreans. The analysis included 139,266 participants and used data from the 2019 Korean Community Health Survey. Only current drinkers were considered in the analysis. The relationship between the alcohol flushing response and depression was determined by logistic regression analysis using SAS 9.4. As a result, more than one-third of the population was found to be current flushers, and the relationship was significant among current flushers and depression (AOR=1.23, 95% CI 1.12–1.35, P-value=0.1ⅹ10-3) compared to never flushers. No association was found between former flushing response and depression. The odds of depression were significantly higher among alcohol flushers who drinks less than 15 g/day alcohol (<5 g/day: AOR=1.21, 95% CI=1.08-1.36, P-value=0.1ⅹ10-3; 5.0-14.9 g/day: AOR=1.40, 95% CI=1.14-1.71, P-value=0.1ⅹ10-3). In conclusion, this study reveals that a significant number of the South Korean population experiences the alcohol flushing response, and the individuals with the response are more likely to feel depressed, even with a small amount of alcohol consumption.
Identification of Polymorphisms in GDF9 and BMP15 Genes in Jamunapari and Crossbred Goats in Bangladesh
Authors: Shaha Mishuk , Miah Gous , Lima Arjuman , Miazi Omar Faruk , Das Ashutosh
Published: December 2021

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two crucial fecundity genes 15 associated with litter size traits in the goat. Our previous study on GDF9 and BMP15 genes detected single nucleotide polymorphisms (SNPs) associated with litter size in Bangladeshi Black Bengal goats. In this study, Jamunapari and crossbred goats of Bangladesh were screened to identify polymorphisms in the GDF9 and BMP15 genes and to assess the association between identified SNPs and litter size. The genomic DNA from 100 goats (50 Jamunapari and 50 crossbred) was used in Polymerase Chain Reaction (PCR) to amplify the exon 2 of the GDF9 and exon 2 of the BMP15 gene. PCR products were sequenced employing the BigDye Terminator cycle sequencing protocol, to identify SNPs. A generalized linear model was utilized to perform the association analysis for identified SNPs and litter size. Seven SNPs were identified, of which four: C818CT, G1073A, G1189A and G1330T were in the GDF9 gene, three: G616T, G735A and G811A were in the BMP15 gene. G735A was a synonymous SNP, whereas the remaining were non-synonymous SNPs. Identified SNP loci in GDF9 were low polymorphic (PIC<0.25) while loci in BMP15 were moderately polymorphic (PIC≥0.25). The genotypes at the G1330T locus had a significant (p<0.05) difference in litter size in Jamunapari goat, but no significant difference was observed for all genotypes at other loci. This study provides additional molecular markers that would be useful for future research on the litter size trait in goats of Bangladesh.
Exploring the Functional and Metabolic Effects of Feeding Garra Fish Meal to Broiler Chickens
Authors: Mebratu Awot Teklu , Asfaw Yohannes Tekle , Janssens Geert Paul Jules
Published: December 2021

The present study evaluated the metabolic and functional effects, beyond nutritive value, of feeding garra meal to broiler chickens. Three hundred twenty Sasso-breed day-old chicks were randomly assigned to four dietary treatments with either 0, 10, 20 or 30% garra meal added on top of a formulated starter and grower basal diets. The experiment lasted for 42 days. There was a gradual increase in feed intake and body weight gain with increasing garra meal addition (p < 0.05). Broiler chickens fed 30% garra meal were more efficient in converting feed to body weight and yielded the highest carcass weight (p < 0.05). Crude protein and crude fat digestibility coefficients were higher with the garra meal receiving groups with the highest values (74.8 ± 1.6 and 92.3 ± 0.6) recorded with 20% and 30% garra meal additions, respectively (p < 0.05). The increase in individual and total esterified carnitine concentrations in dried blood spots demonstrated the elevated metabolic rate with increasing garra meal addition (p < 0.05). A better supply of glucogenic substrate to the citric acid cycle was seen with garra meal addition due to the increase of propionylcarnitine to acetylcarnitine ratio (p < 0.05) while no effect was observed on ketogenesis as measured through the 3-hydroxybutyrylcarnitine to acetylcarnitine ratio (p > 0.05). Yet, it likely showed that part of the higher amino acids (Leucine, Methionine and Citrulline) uptake due to garra meal was used as glucogenic substrate (p < 0.05). Histo-morphology showed gradual increases in villus height, crypt depth and their ratio in the proximal parts of the intestine (duodenum and jejunum) with the opposite results observed in the more distal part (ileum) with garra meal addition (p < 0.05). It can be concluded that garra meal strongly improved broiler performance when added to a plant-based diet and only few parameters warranted for caution when using more up to 30% garra meal addition. Beyond growth performance, garra meal generated a shift to a more efficient digestion and nutrient metabolism, and induced changes in edible muscle that may aid in solving shortages in the Ethiopian human diet.
SARS-Cov 2 infection and anti-tuberculosis immunity: temporal association or real protective role?
Authors: SANAA HAMMI , MYRIEM BOURKIA , NAJDI ADIL , RAJAE CHAHBOUNE , KARIMA RISSOUL , EDDINE BOURKADI JAMAL , JOUDA BENAMOR , FATEMA EL BOUZOUIKI , SOUMIYA EL BACHIRI , MOHAMMED MOUMKIN , RACHID ISMAILI , MOURABAIT NADIRA , OUAFAE KAISSI , ZERROUKI ASMAE , GROURINDA ADIL , BOUSGHEIRI FADILA , BELAFKI HASSANA , MHAMED HARIF , MOHAMED AHALAT
Published: December 2021

Introduction: According to the literature consulted to date, there is epidemiological heterogeneity of covid 19 between countries depending on their vaccination policy, in particular BCG vaccination. These findings have led to several hypotheses, including the protective role of immunity induced by the BCG tuberculosis vaccine against Covid-19 infection. The immunity induced by the BCG vaccine significantly increases the secretion of pro-inflammatory cytokines, in particular IL-1B, which has been shown to play an essential role in antiviral immunity. This cross-immunity, although not specific, if highlighted, is a real providence that must be taken advantage of in the face of this pandemic. The main objective of this study is to rule out or confirm that anti-tuberculosis immunity protects against SARS-COV 2 in our context. Materiel and methods: Two groups will be compared: cases infected with the virus and controls who have never been infected with the virus. Both case and control groups will undergo a tuberculin skin test: the intra dermal tuberculin reaction (IDR). Results: We found that our control group had a high IDR immunity value, with an IDR tuberculin positive percentage of 67.2%. This suggests that immunity to IDR is a protective factor against coronavirus disease. Conclusion: The hypothesis of nonspecific anti-tuberculosis protection deserves further verification studies; it would have large positive repercussions for developing countries.
Research and Development of Parametric Design Platform for Series Complex Cutting Tools
Authors: Lin Zhi , Yue Caixu , Hu Desheng , Liu Xianli , Liang Steven Y. , Jiang Zhipeng , Zhang Anshan , Yue Daxun
Published: December 2021

Metal cutting tool is an important part of machining, and its performance directly affects the manufacturing efficiency and machining quality of products. With the increasing demands in manufacturing industry of cutting performance, machining efficiency, customization and quick response, traditional tool design methods can no longer meet the above requirements due to many repetitive work, large amount of calculation, complex process and low efficiency. Parametric design has become a new development direction of customized tool design because of its fast, stable and accurate characteristics. In this paper, the parametric design of cutting tools is realized based on the process construction method of model generating history. The tool parametric design platform is developed by the method of secondary development of commercial CAD software. The platform realizes automatic operation in the background without the main interface of CAD software, completes the parametric modeling process of tools, generates 2D drawings and 3D models conforming to ISO 13399 standard, and realizes the cloud storage function of model data. The platform has simple operation and good man-machine interaction, and realizes the parametric design of many kinds of tools. Compare with that traditional modeling method, using this parametric modeling platform, the modeling efficiency is increased by 90% on average. This platform is of great significance to improve the design efficiency of complex customized tools and shorten the original design cycle by 30%.
Deep Learning Based Classification of Time Series of Chaotic Systems over Graphic Images
Authors: UZUN Süleyman , KAÇAR Sezgin , ARICIOĞLU Burak
Published: December 2021

In this study, for the first time in the literature, identification of different chaotic systems by classifying graphic images of their time series with deep learning methods is aimed. For this purpose, a data set is generated that consists of the graphic images of time series of the most known three chaotic systems: Lorenz, Chen, and Rossler systems. The time series are obtained for different parameter values, initial conditions, step size and time lengths. After generating the data set, a high-accuracy classification is performed by using transfer learning method. In the study, the most accepted deep learning models of the transfer learning methods are employed. These models are SqueezeNet, VGG-19, AlexNet, ResNet50, ResNet101, DenseNet201, ShuffleNet and GoogLeNet. As a result of the study, classification accuracy is found between 96% and 97% depending on the problem. Thus, this study makes association of real time random signals with a mathematical system possible.
Retrospective Evaluation of Variations in Root Canal Morphology of Permanent Maxillary Premolars Among the Emirate Population
Authors: Alnaqbi Hajir S.Y. , Gorduysus Mehmet Omer , Shehadat Saaid Al , Bayatti Saad Wahbi Al , Mahmoud Ibrahim
Published: December 2021

Background: This research aims to identify the most common morphology of the upper premolars in a group of local and nonlocal people in the UAE using cone-beam computed tomography (CBCT).Methods: CBCT images of a total of 214 intact maxillary premolars were analysed with 3D reconstruction GALAXIS viewer software. The Pearson Chi squared test and the two samples t test were applied.Results: In all, 90% of the maxillary first premolars had two roots (92% females, 88% males, 83% locals, 96% nonlocals). A total of 52% of maxillary second premolars had two roots (47% females, 56% males, 38% locals, 67% nonlocals). Two cases had three roots among local males. A significant difference of one root in the maxillary second premolar was observed between locals (63%) and nonlocals (33%), while two roots were higher among nonlocals (67%) than locals (37%, p = 0.002). Three roots were discovered in two teeth of the local UAE first premolar. The most common canal morphology in the maxillary first premolar group among local UAE subjects was type V (52%), and among nonlocal UAE subjects was type V (59%). Additional types included 7 (13.2%) identiﬁed and unrelated to the Vertucci classification. The dominant canal morphology in the maxillary second premolar among local UAE subjects was type II (32%), and among nonlocal UAE subjects was type V (25%); among the additional types, 12 (23.1%) were identiﬁed and not related to the Vertucci classification. There was a significant difference in the distance from the pulp chamber roof to the cementoenamel junction (CEJ) and the measurement between the single-rooted maxillary premolar CBCT for local UAE subjects was 1.36 mm (SD ±0.75) and for nonlocal subjects was 1 mm (SD ±0.27, p = 0.049). There were statistically significant differences in all measurements between multiple rooted maxillary premolar CBCTs for local UAE and South Asian subjects (p < 0.05)Conclusions: The results suggest a more quantitative approach to maxillary first and second premolar access cavity preparation in the UAE population to prevent errors and iatrogenic damage when identifying the canals; using CBCT measurements for more precise access preparations may be advantageous.
The Application of R.E.N.A.L. Nephrometry Score In Laparoscopic Partial Nephrectomy With Zero Ischemia And Sutureless
Authors: Mu Yi , Chen Kehang , He Jun , Chen Peng , Liu Miao , Tang Kaifa
Published: December 2021

Background: To evaluate the application of R.E.N.A.L. nephrometry score (RNS) in laparoscopic partial nephrectomy (LPN) with zero ischemia and sutureless surgery, and to explore the efficacy and safety of zero ischemia and seamless LPN in the treatment of renal cell carcinoma.Methods: The clinical data of 67 patients with renal cell carcinoma treated by LPN in the affiliated Hospital of Guizhou Medical University from January 2016 to July 2020 were analyzed retrospectively. The patients were divided into renal artery occlusion group (n=31) and non-occlusion group (n=36). All cases were divided according to their RNS (low, moderate, and high), and the perioperative condition, postoperative complications, postoperative recovery and changes of renal function in the two groups were analyzed.Results: According to the RNS, all cases were classified in low-complex. Both groups successfully completed the operation without operative complications. Compared with the renal artery occlusion group, the non-occlusion group had a shorter operation time (35.51±20.48 min), shorter hospital stay (6.72±4.39 d), and no significant difference in intraoperative blood loss(50.39±30.19 ml). During the 6-month follow-up, the creatinine value of the renal function in the non-occlusion group (78.47±10.98μmol/L) was lower than that in the occlusion group(98.21±8.06μmol/L).Conclusion: Zero-ischemia sutureless LPN technique can effectively reduce the time of ischemia and avoid renal ischemia-reperfusion injury. This surgical technique may be a feasible surgical method for the treatment of low RNS renal cell carcinoma.
The Detailed Doubly Fed Induction Wind Generator for Electromagnetic Transients Calculations and its Initialization in ATP
Authors: Venerdini Guillermo David Guidi , Mombello Enrique Esteban
Published: December 2021

The Alternative Transients Program (ATP) is one of the most used electromagnetic transient programs due to its powerful modeling capability and versatility. However, it has limitations as regards the automatic initialization of power electronics devices and control systems. To overcome this drawback, a simple methodology is presented in this paper to initialize a detailed model of a doubly fed induction wind generator implemented in ATP. The methodology is based on the automatic initialization of this device and it is divided into two stages. The first one consists of offline calculations to obtain initial steady-state values of certain model variables and, in the second one, these results are used as ATP model parameters. The simulation is started by means of auxiliary switches also included in the model. To validate the methodology, the transient and steady-state behavior of 4 case studies was evaluated. The analysis of these results shows that the steady-state values calculated by ATP for t = 0 are the desired ones and the oscillograms present a steady-state condition. The proposed methodology makes it possible to accurately initialize a detailed DFIG-type generator model in ATP, without the need to sacrifice simulation time to wait for variables to reach a steady state.
Engineering of Calcium Alginate- PANI@Sawdust Wood hydrogel Bio-beads for the Removal of the Sulfonate Groups-Containing Orange G dye from Aqueous Solution
Authors: IMGHARN ABDELAZIZ , Aarab Nouh , Hsini Abdelghani , Naciri Yassine , Elhoudi Mohammed , Haki Mohamed Ait , Laabd Mohamed , Lakhmiri Rajae , Albourine Abdallah
Published: December 2021

The aim of this work is to investigate the adsorption performance of orange G (OG) dye from aqueous solutions employing PANI@sawdust biocomposite enrobed by calcium-alginate biobeads (Alg-PANI@SD). The as-prepared adsorbent was characterized by scanning-electron-microscopy (SEM), X-ray energy dispersive spectroscopy (EDS) and Fourier transforms infrared (FT-IR) spectroscopy, and used to remove Orange G dye from water. batch tests were performed as a function of adsorbent dosage, pH, contact time, interfering ions and initial OG dye concentration. Experimental results show that the kinetic model of pseudo-first-order (PFO) and Freundlich isotherm provided a good fitting of the whole experimental data. The results revealed that the as-prepared tricomposite Alg-PANI@SD, has the potential to be applied as a low-cost adsorbent for the adsorption of OG dye from aqueous media.
Seasonal variations of locomotor activity rhythms in melatonin-proficient and -deficient mice under seminatural outdoor conditions
Authors:   , Metzger Joshua
Published: December 2021

Locomotor activity patterns of laboratory mice are widely used to analyze circadian mechanisms, but most investigations have been performed under standardized laboratory conditions. Outdoors, animals are exposed to daily changes in photoperiod and other abiotic cues that might influence their circadian system. To investigate how the locomotor activity patterns under outdoor conditions compare to controlled laboratory conditions, we placed 2 laboratory mouse strains (melatonin-deficient C57Bl and melatonin-proficient C3H) in the garden of the Dr. Senckenbergische Anatomie in Frankfurt am Main. The mice were kept singly in cages equipped with an infrared locomotion detector, a hiding box, nesting material, and with food and water ad libitum. The locomotor activity of each mouse was recorded for 1 year, together with data on ambient temperature, light, and humidity. Chronotype, chronotype stability, total daily activity, duration of the activity period, and daily diurnality indices were determined from the actograms. C3H mice showed clear seasonal differences in the chronotype, its stability, the total daily activity, and the duration of the activity period. These pronounced seasonal differences were not observed in the C57Bl. In both strains, the onset of the main activity period was mainly determined by the evening dusk, whereas the offset was influenced by the ambient temperature. The actograms did not reveal infra-, ultradian, or lunar rhythms or a weekday/weekend pattern. Under outdoor conditions, the 2 strains retained their nocturnal locomotor identity as observed in the laboratory. Our results indicate that the chronotype displays a seasonal plasticity that may depend on the melatoninergic system. Photoperiod and ambient temperature are the most potent abiotic entraining cues. The timing of the evening dusk mainly affects the onset of the activity period; the ambient temperature during this period influences the latter’s duration. Humidity, overall light intensities, and human activities do not affect the locomotor behavior.
A POLÍTICA DE FINANCIAMENTO DA EDUCAÇÃO NO ESTADO DE RONDÔNIA ENTRE 2007 E 2019
Authors: Nascimento Alessandra Bertasi , Fernandes Maria Dilnéia Espíndola , Sauer Leandro
Published: December 2021

O texto analisa, em contexto federativo, a política de financiamento da educação no estado de Rondônia, de 2007 a 2019. Trabalhou-se com a legislação educacional, com os relatórios resumidos da execução orçamentária, documentos da imprensa e do movimento sindical docente. Constatou-se que a política de financiamento da educação no estado se desenvolveu em dois ciclos no período, porque foi subordinada à política econômica. O primeiro ciclo foi marcado pela ampliação do direito à educação. O segundo ciclo moveu-se pela austeridade fiscal, rompendo o ciclo imediatamente anterior.
Natural and Semisynthetic Triterpenes from Combretum leprosum Mart. with Antiplasmodial Activity
Authors: Passarini Guilherme , Ferreira Amália , Moreira-Dill Leandro , Zanchi Fernando , de Jesus Aurileya , Facundo Valdir , Teles Carolina
Published: December 2021

Malaria is responsible for thousands of deaths each year. Currently, artemisinin combination therapy (ACT) is used as first-choice medication against the disease. However, the emergence of resistant strains prompts the search for alternative compounds. The present study aimed to investigate the antiplasmodial activities of natural triterpenes (compounds 1 and 2), and semisynthetic derivatives 1a, 1b, 1c, and 1d. Antiplasmodial assays were carried out using the SYBR Green technique, whereas cytotoxicity was evaluated by the MTT (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) method. Hemolytic assays were performed on human erythrocytes. An in silico analysis of the compounds against PfENR (Plasmodium falciparum 2-trans-enoyl-reductase) was carried out by molecular docking. Experiments with 1, and its derivatives against P. falciparum showed that 1a was very similar in terms of biological activity to compound 1 (half maximal inhibitory concentration (IC50) ca. 4 μM), whereas 1b, 1c, and 1d had reduced antiplasmodial activities (IC50 between 8-103 μM). The selectivity indexes of 1 and 1d for HepG2, and Vero cells were > 10. Docking results partially agreed with the in vitro experiments, with 1 and 1c having the best and worst affinities with PfENR, respectively. In conclusion, the results showed that 1 and 1d may serve as biotechnological tools in the development of antimalarial drugs.
Spatial–temporal characteristics and driving factors of flash floods in Shaanxi Province considering regional differentiation
Authors: Zhang Han , Luo Jungang , Wu Jingyan , Yu Mengjie
Published: December 2021

Flash floods show strong regional differentiation in spatial–temporal distribution and driving forces, thereby hindering their effective prevention and control. This study analyzed the spatiotemporal characteristics of flash floods in Shaanxi Province, China, differentiated among the northern Shaanxi (NS), Guanzhong (GZ), and southern Shaanxi (SS) regions based on the Mann–Kendall, Theil–Sen Median, and standard deviation ellipse methods. The main factors driving disasters and their interactions in each region were then identified within the three categories of precipitation factor (PPF), surface environment factor, and human activity factor (HAF) based on a geographical detector. Finally, the differences in flash flood characteristics among the NS, GZ, and SS regions were analyzed. The results showed that flash floods in Shaanxi Province are greatly affected by the PPF and the HAF, although the spatial–temporal characteristics and disaster-causing factors were significantly different in each region. The regions were ranked according to the number and growth trends of flash floods as follows: SS > GZ > NS. Furthermore, flash floods were affected by multiple factors, with the interaction between factors acting as a driving force of flash floods. The results of this study can provide a reference for the management of flash floods under regional differentiation.
Biogeochemical responses of a highly polluted tropical coastal lagoon after the passage of a strong hurricane (Hurricane Irma)
Authors: González-De Zayas Roberto , Merino-Ibarra Martín , Lestayo González Julio A. , Chaviano-Fernández Yida , Alatorre Mendieta Miguel A. , Pupo Felipe Matos , Castillo-Sandoval Fermín S.
Published: December 2021

Laguna Larga (Cayo Coco, Cuba) is a eutrophic coastal lagoon due to tourism development. As part of long-term monitoring of Laguna Larga, we were able to follow the lagoon's water quality from 2015 to 2018 and could assess the impacts of Hurricane Irma (September 8–9, 2017) by intensifying our sampling frequency. Physicochemical parameters (salinity, pH, dissolved oxygen, dissolved inorganic nitrogen, dissolved reactive silicate and total nitrogen) exhibited significant variations associated with Hurricane Irma. Salinity decreased due to the extraordinary rainfall of the hurricane (339.8 mm/24 h, a new record for Cayo Coco). The water level in the lagoon rose 0.85 m. Strong hurricane winds and intense runoff drove organic matter and sediment resuspension. Anoxia and an increase of nutrients occurred throughout the lagoon. The main biogeochemical impact was that it boosted these eutrophic conditions of the lagoon, to levels that lasted for several months. A significant correlation among nutrients, salinity and dissolved oxygen was found. After 6 months, water quality in the lagoon had recovered to conditions similar to those before the hurricane. The case of Laguna Larga shows that those coastal systems under anthropic pressure can take longer to recover after extreme climatic events, and highlights the need for long-term monitoring of tropical coastal ecosystems.
Comparison between double slope solar still and fourfold slope solar still: energy, exergy, exergoeconomic, and enviroeconomic evaluation
Authors: Sun Zhilin , Tu Wenrong , Fang Shibiao , Zhong Wenjun
Published: December 2021

This paper proposes a single basin fourfold slope solar still, which includes a fourfold slope glass cover plate used for solar heat collection and steam condensation. In order to show the efficiency of the fourfold slope solar still, comparative experiments are conducted under the winter climate conditions in Hangzhou for testing the operational performance of a double slope type solar still (DOSS) and the fourfold slope still (FOSS), so as to make a comparative analysis between them. Results show that the productivity of the fourfold slope still is 19.51% higher than that of the double slope still, and the fourfold slope solar still enhances the average hourly energy efficiency by 31.11%. According to the energy method, the energy payback time values of the fourfold slope solar still and double slope solar still are 64.88 months and 75.42 months respectively. According to the environmental parameter method, FOSS and DOSS reduce 5.47 tons and 4.58 tons of CO2 respectively. The corresponding values based on the exergy environment parameters are 0.21 and 0.18 tons of CO2, respectively. The fourfold slope solar still has a more obvious emission reduction function than the double slope solar still. The cost of the distilled water of the fourfold slope solar still is 0.28 RMB/kg, and the cost of the double slope solar still is 0.30 RMB/kg. In addition, the environmental and economic parameters of the fourfold slope still and double slope still are 79.29$ (561.37RMB) and 66.35$ (469.76RMB), respectively. While, the corresponding values based on the exergoenvironmental parameter are 3.05$ (21.59RMB) and 2.56$ (18.12RMB), respectively. From the analysis of exergoeconomic and exergoenvironmental parameters, the fourfold slope single basin solar still appears to be more effective.
An optimized PSO-ANN model for improved prediction of water treatment desalination plant performance
Authors: Mahadeva R. , Kumar M. , Patole S. P. , Manik G.
Published: December 2021

An accurate prediction of the performance of water treatment desalination plants could directly improve the global socio-economic balance. In this regard, many researchers have been engaged in the various artificial intelligence applied soft computing techniques to predict actual process outcomes. Inspired by the significance of such techniques, an optimized Particle Swarm Optimization based Artificial Neural Network (PSO-ANN) technique has been proposed herewith to predict an accurate performance of the reverse osmosis (RO) based water treatment desalination plants. Literature suggests that the improvements of the soft computing models depend on their modeling parameters. Therefore, we have included an extended list of nine modeling parameters with a systematic indepth investigation to explore their optimal values. Finally, the model's simulations results (R2 = 99.1%, Error = 0.006) were found superior to the existing ANN models (R2 = 98.8%, Error = 0.060), with the same experimental datasets. Additionally, the simulation results recommend that among many parameters considered, the number of hidden layer nodes (n), swarm sizes (SS), and the weight of inertia (ω) play a major role in the model optimization. This study for a more accurate prediction of the plant's performance shall pave the way for the process design and control engineers to improve the plant efficiency further.
Psalm 37 zbiorem sentencji mądrościowych? Analiza Psalmu 37 i pytanie o zakorzenienie psalmów mądrościowych w Psałterzu
Authors: Slawik Jakub
Published: December 2021

Psalm 37 uchodzi za zbiór sentencji mądrościowych, przypominający Księgę Przysłów. Szczegółowa analiza tego Psalmu prowadzi do wniosku, że jest on kunsztowną kompozycją (pomijając drobne redakcyjne uzupełnienie) i jako taki powinien być interpretowany. Rzeczowo przynależy on do Psałterza (umieszczony w końcowej części pierwszego Psałterza Dawidowego), gdyż z naciskiem wzywa odbiorcę do pokładania ufności w Bogu, który ocala sprawiedliwego, a niegodziwego przywodzi do zagłady. Jest znacznie bardziej niż zbiory z Księgi Przysłów naznaczony religijnie i liturgicznie.
A formação de professores para uma prática inovadora sob a óptica do pensamento complexo de Edgar Morin: o ensino da compreensão
Authors: Cararo Juliana Fernandes Junges , Prigol Edna Liz , Behrens Marilda Aparecida
Published: December 2021

Este artigo apresenta o resultado de uma pesquisa-ação que analisou a participação de 19 professores no curso on-line “Formação de Professores Para Uma Prática Inovadora sob a Óptica do Pensamento Complexo de Edgar Morin”, composto por sete módulos referenciados no livro Sete saberes necessários para a educação do futuro (MORIN, 2000), promovido pelo grupo de pesquisa Paradigmas Educacionais e a Formação de Professores (Pefop). Identificaram-se qualitativamente as principais contribuições apontadas pelos participantes do curso, focando o sexto saber (ensinar a compreensão), nas três etapas em que foram chamados à reflexão e discussão. Os professores envolvidos apresentaram um bom aprofundamento, sobretudo por estarem em formação e terem cursado anteriormente outros cinco módulos do curso. Revelaram contribuições relevantes à construção de seu conhecimento, intenções e práticas vivenciadas para a transformação da educação, fundadas no pensamento complexo e no ensino para a compreensão, demonstrando um possível caminho à inovação pedagógica.
“O pleno desenvolvimento da pessoa” e sua adesão à educação superior
Authors: Rocha Marcelo Haponiuk , Pianovski Vieira Alboni Marisa Dudeque
Published: December 2021

O estudo tem como objetivo destacar as incorporações do termo Educação como matéria constitucional, sua presença em Constituições anteriores, as razões que levaram à inclusão do termo “Pleno Desenvolvimento da Pessoa” e sua adesão ou não à Educação Superior. A metodologia seguida foi o raciocínio dedutivo, amparado em pesquisa bibliográfica e normas legais relacionadas ao termo pesquisado. A investigação tem como características ser multi/inter/transdisciplinar, agregadora e aglutinadora, das áreas dos conhecimentos usadas como chaves. Como resultado, verifica-se que ajustar padrões culturais e econômicos replicados por sucessivas gerações faz-se necessário à obtenção de um equilíbrio entre desenvolvimento econômico e social e ao desenvolvimento do ser humano.
Jogos de tabuleiro: recurso lúdico na aprendizagem de crianças em situação de vulnerabilidade
Authors: Vasconcellos Talita Silva Perussi , Orlando Rosimeire Maria
Published: December 2021

Este artigo é um recorte de uma dissertação de mestrado, realizada no Programa de Pós-graduação em Educação Especial da Universidade Federal de São Carlos. Teve como objetivo geral observar e analisar o uso do jogo de tabuleiro no processo de apropriação de habilidades relacionadas à leitura e escrita de crianças em situação de vulnerabilidade social. A presente pesquisa se realizou em uma Organização da Sociedade Civil do interior do estado de São Paulo. Foram participantes deste estudo quatorze meninas de sete a dez anos de idade que frequentavam a referida organização. A pesquisa de abordagem qualitativa, caracterizada como pesquisa participante, se valeu dos procedimentos de observação, entrevista e avaliação pedagógica. Contou com três etapas: 1. Sondagem inicial; 2. Intervenção com jogos de tabuleiro; 3. Finalização. Os resultados mostraram um ganho de habilidades ao processo de aquisição de leitura e escrita, visto que a aplicação das avaliações demonstrou que todas as meninas ganharam habilidades de escrita novas possivelmente por influência do jogo.
Diários de formação: potencialidades para a ampliação dos letramentos acadêmicos e pedagógicos
Authors: Ferreira Helena Maria , Lima Francine de Paulo Martins , Signorelli Gláucia
Published: December 2021

O presente artigo tem por objetivo discorrer acerca das contribuições dos diários de formação como estratégia metodológica para a ampliação dos letramentos acadêmicos e dos letramentos pedagógicos. O artigo ensaístico aqui empreendido trata da articulação entre a formação docente e o conceito de letramentos, buscando considerar a relevância de um percurso formativo que promova uma compreensão ativa responsiva dos discursos acerca do processo educativo e dos dizeres institucionalizados sobre as práticas pedagógicas. A partir de uma pesquisa teórica, os resultados apontam para a relevância dos diários de formação como potencializadores dos processos de investigação-reflexão-ação necessários à constituição da docência no contexto da formação inicial, ampliando as possibilidades de letramentos acadêmicos e letramentos pedagógicos.
Implicações da prática escolar na construção de identidades juvenis de jovens egressos do ensino médio
Authors: Holdorf Marlene , Manske George Saliba , Zoboli Fabio
Published: December 2021

Estabelecemos análises sobre a construção identitária de jovens e algumas implicações relacionadas à função da escola enquanto formadora destes sujeitos. A pesquisa foi realizada a partir de questionário semiestruturado através de formulário eletrônico, assumindo uma abordagem qualitativa. O processo de escuta do sujeito jovem é interpretado nesta pesquisa como instrumento de captação da significação entre o vivido e o declarado, como uma possibilidade de interpretação das suas vivências possibilitando compreensões da função da escola em relação ao desenvolvimento de suas práticas. Apresentamos os desafios da inserção social dos jovens no mercado de trabalho, assim como, a transição do jovem para o mundo adulto e suas expectativas em relação a escola e aquilo que se desenvolveu naquele espaço. Consideramos a escola enquanto instituição educativa com vínculo em processos de construção social e histórica destes sujeitos que se apresentam num mundo globalizado em constante adequação e transformação.
Atos de currículo e estratégias aprendentes nas práticas das culturas infantis com as tecnologias digitais
Authors: Oliveira Bruna Santana de , Lucena Simone
Published: December 2021

Este artigo tem como objetivo compreender os tipos de estratégias aprendentes nas práticas das culturas infantis com as tecnologias digitais. Assim, com um olhar plural para o fenômeno, utilizamos a epistemologia multirreferencial bricolada com as estratégias da metodologia de pesquisa com crianças. Para tanto, essa investigação qualitativa se alicerçou nos pressupostos de inspiração na etnografia para a escuta das vozes das crianças participantes. Os dispositivos de pesquisa utilizados para a construção dos dados foram: diário de campo e observação com duração de quatro meses no espaço privado familiar de duas crianças com três e cinco anos. Dentre os resultados, identificamos como as crianças apresentam estratégias diferenciadas de aprendizagens quando estão imersas nos espaços virtuais com as tecnologias digitais. Nesse contato, elas aprendem palavras em língua estrangeira, letras, cores, números, formas e, além disso, fazem conexão com os conteúdos escolares, ou seja, produzem atos de currículo.
A Proteomics Study of the Subacute Toxicity of Rat Brain after Long-
Term Exposure of Gelsemium elegans
Authors: Zuo Meng-Ting , Huang Si-Juan , Wu Yong , Tang Mo-Huan , Yu Hui , Qi Xue-Jia , Liu Zhao-Ying
Published: December 2021

Background:

Gelsemium elegans (G. elegans) has been shown to have strong pharmacological
and pharmacodynamic effects in relevant studies both in China and USA. G. elegans has
been used as a traditional medicine to treat a variety of diseases and even has the potential to be an
alternative to laboratory synthesized drugs. However, its toxicity severely limited its application
and development. At present, there is little attention paid to protein changes in toxicity.

Aim:

This study investigated the toxicity effects after long-term exposure of G. elegans of the rat
brain through proteomic.

Method:

11 differential abundance proteins were detected, among which 8 proteins were higher
in the G. elegans- exposure group than in the control group, including Ig-like domain-containing
protein (N/A), receptor-type tyrosine-protein phosphatase C (Ptprc), disheveled segment polarity
protein 3 (Dvl3), trafficking protein particle complex 12 (Trappc12), seizure-related 6 homologlike
(Sez6l), transmembrane 9 superfamily member 4 (Tm9sf4), DENN domain-containing protein
5A (Dennd5a) and Tle4, whereas the other 3 proteins do the opposite including Golgi to ER traffic
protein 4 (Get4), vacuolar protein sorting 4 homolog B (Vps4b) and cadherin-related 23 (CDH23).
Furthermore, we performed validation of WB analysis on the key protein CDH23.

Results:

Finally, only fewer proteins and related metabolic pathways were affected, indicating that
there was no accumulative toxicity of G. elegans. G. elegans has the potential to develop and utilize
of its pharmacological activity. CHD23, however, is a protein associated with hearing.

Conclusion:

Whether the hearing impairment is a sequela after G. elegans exposure remains to be
further studied.