bluuebunny/crossref_metadata_2025 huggingface dataset:
MICROCIRCULATION OF THE SKIN IN WORKERS OF GAS-PROCESSING PLANT
Authors: Yanchevskaya E. Yu , Mesnyankina Olga A.
Published: September 2020

Microcirculatory disorders play an important role in the pathogenesis of dermatoses, including those caused by the influence of adverse factors of production environment. 158 men from the Astrakhan gas processing plant (AGPS) aged from 28 to 59 years (40.23 ± 0.49 years) and 77 healthy volunteers, resident in the city of Astrakhan in age from 25 to 55 years (38,18 ± 0,99 years) were examined. Depending on the technological stage of processing of reservoir gas workers AGPS had contact with various harmful and dangerous factors, among which were the formation of gas, elementary sulfur, hydrocarbons, saturated and unsaturated aliphatic compound, nitrogen oxides, etc. In more than 90% of cases in the skin of workers AGPS serious violations of blood perfusion in small vessels, and in the surface areas more often than in the deep, while marked asymmetry of cutaneous microcirculation were revealed. Laser Doppler flowmetry can be recommended as a noninvasive method of monitoring the condition of microcirculation and early diagnosis of premorbid changes in the skin of workers of the gas processing plant exposed to adverse factors of production environment.
COMPARATIVE ANALYSIS OF THE FACE AND NECK SKIN ELASTICITY IN 20-30 YEARS WOMEN
Authors: Korolkova Tatiyana N. , Ambartsumyan L. L , Shepilova I. A , Maslova A. V
Published: September 2020

Prevention and correction of external signs of the face and neck aging are the main direction of modern cosmetology. The study of the skin functions of various zones of face and neck will allow to carry out more effectively cosmetic effects. The aim is to study the features of the elasticity of facial skin (forehead, skin around the eyes, cheeks) and neck in patients without external signs of skin aging. Material and methods. Elasticity of the face and neck skin was determined in 63 women aged 20-30 years, who made up four comparison groups: in the 1st group (22 women) the elasticity of the forehead skin was studied, in the 2nd group (43 women) - around eye, in the third group (49 women) - cheeks, in the 4th group (24 women) - the neck. To measure the elasticity of the skin the Cutometer MPA 580 (“Courage Khazaka”, Germany) was used. Results. The comparative analysis was performed with the forehead skin. The skin around the eyes was 61-68% more stretchy (R0, R8), 65% worse returned to the initial state (R1), including 26-62% with repeated suction cycles sensor (R3, R4, R9), by 1-11% less elastic (R2, R5, R7), by elastic-viscous properties (R6) is 26% better, but overall its elasticity is lower by 35-53% (F0, F1). The cheek skin is 91- 104% more stretchy (R0, R8), worse returns to the initial state (R1) by 22%, including by 10-82% with repeated suction cycles by the sensor (R3, R4, R9),13% more elastic (R2) and 15% less elastic (R5, R7), the elastic-viscous properties (R6) 41% better, but overall its elasticity is lower by 31-100% (F0, F1) . The neck skin is 186-257% more stretchable (R0, R8), 6% worse returns to the initial state (R1), including 13-164% with repeated suction cycles by the sensor (R3, R4, R9), by 11-28% more elastic (R2, R5, R7), by elastic-viscous properties (R6) 50% better, but overall its elasticity is lower by 88-153% (F0, F1). Conclusion. The skin of the forehead, around the eyes, cheeks and neck, according to the elasticity indices, has significant differences. The obtained data should be taken into account when carrying out various cosmetology techniques, further study are needed.
PSORIASIS VS MALIGNANCIES: POSSIBLE INTERRELATION AND POTENTIAL RISKS
Authors: Osina A. V , Ponich E. S , Kruglova Larisa S.
Published: September 2020

To date one of the most discussed problems in the context of psoriasis is the possibility of correlation between the psoriatic process, considering its systemic nature, and the risk of cancer developing. Such interrelation can be caused both by systemic chronic inflammatory process and by methods of therapy. The purpose of this literature review is to assess the risk of developing malignant neoplasms of various organs and systems, as well as the factors that determine it, in patients with psoriasis in comparison with the general population. The mechanisms of action as well as early and remote side effects of the current treatment are described. The literature data on the risk of their carcinogenic effects are presented. The results of studies of a number of other factors acting as possible initiators of carcinogenesis in patients with psoriasis are highlighted, among them: the presence of a systemic inflammatory reaction, the severity and duration of the course of the disease, and also the comorbid states.
RESULTS OF OXYGEN-OZONE MIX IN THE TREATMENT OF VITILIGO
Authors: Gereykhanova Lyudmila G. , Lomonosov K. M , Melnikova Yu. G
Published: September 2020

Obtaining new data on the role of the antioxidant system in vitiligo in the future can contribute to the development of new effective and safe methods for combining vitiligo with an oxygen-ozone mixture with a minimal risk of side effects, as well as a short duration of treatment and low financial costs. Materials and methods. We observed 50 patients with vitiligo in the advanced stage of the disease, aged 20-59 years. Before the start of the course of ozonotherapy and after its completion in 2-4 weeks, the main indicators of the antioxidant system were studied (the following superoxide dismutase, glutathione peroxidase, glutathione, malonic dialdehyde, 8-OH-deoxyguanosine). All patients received systemic oxygen-ozone mixture therapy by intravenous injection of ozonized saline (OBS). The amount of the injected solution is 300-400 ml, the duration of the procedure is 30-60 minutes. The procedures performed 3 times a week; the course is 9-10 procedures. The tolerability of the procedures was satisfactory in all cases, no side effects were observed. Results. As a result of the treatment the stop of the progression of vitiligo was noted in 40 (80%) patients in the form of diffuse or point repigmentation, a decrease in the area of depigmented spots. This clinical picture correlated with the normalization of the indices of oxidative stress, which was manifested by a significant decrease in the level of malonic dialdehyde and 8-OH-deoxyguanosine against a background of an increase in the concentration of glutathione and glutathione peroxidase on average in 1.5 times.
CONFOCAL SCANNING LASER MICROSCOPY IN ASSESSING THE EFFICACY OF AUTOLOGOUS PLATELET-ENRICHED PLASMA WHEN CORRECTING AGE-RELATED CHANGES IN FACIAL SKIN
Authors: Olisova Olga Yu. , Karagadyan A. D , Garanyan L. G , Allenova A. S
Published: September 2020

The efficacy of using autologous platelet-enriched plasma (auto-OTP) in women of different age groups with involutionally altered facial skin by the method of confocal laser scanning microscopy was evaluated. Own results of treatment of 50 patients aged from 35 to 55 years with clinical manifestations of involutionally altered facial skin are presented. As a result of the therapy, a decrease in the clinical signs of aging was observed in all women, but the clinical effect was more pronounced in the age group from 35 to 45 years (97%, of which 76% was significant improvement, 21% was improvement). In the second group (46-55 years), the decrease in clinical signs of aging after the course of procedures was observed in 86%, of which a significant improvement was in 39%, improvement in 47%, without effect 14%. With the help of confocal laser scanning microscopy it was established that in all patients the intradermal administration of auto-OTP promoted the improvement of the structural and functional organization of the epidermis and dermis, increasing the thickness of the dermal layer. The received data testify to high efficiency and safety of application of auto-OTP in correction of involutional skin changes.
PAGES OF HISTORY OF THE KAZAN SCIENTIFIC SCHOOL OF DERMATOVENEREOLOGY: THE LIFE AND WORK OF V.F. BURGSDORF
Authors: Faizullina Elena V. , Fedorova N. A , Novruzova A. A , Leukhin R. V
Published: September 2020

The main stages of life and activity of V.F. Burgsdorf (1864-1935), his scientific achievements and priorities as the founder of one of the largest scientific schools in Russia are described. The representatives of this school made a huge contribution to the development of national dermatovenereology. Special attention was paid to the contribution of V.F. Burgsdorf in the creation of the second Russia svetlichnoe (phototherapy) offices in the STI clinic (Skin and Venereologic clinic) of A.G. Gе in Kazan on the territory of which currently is the Republican dermatovenerologic Dispensary. The work of A.G. Gе (1889-1925) in the STI clinic became one of the most productive periods of life and activities of V.F. Burgsdorf. In November 1900 V.F. Burgsdorf opens svetlichnoe (phototherapy) office with the support of prof. A.G. GE. Due to his medical and public authority, V.F. Borgsdorf received a large donation from the Empress Maria Feodorovna for his further development. V.F. Burgsdorf devoted much of his life to the development of treatment and prevention of skin and venereal diseases, organization of scientific researches and improvement of medical education in Russia. V.F. Burgsdorf greatly improved the system of medical care for patients.
ERYTHRODERMA AND ANTITUBERCULOUS THERAPY: CLINICAL CASE
Authors: Zaslavsky Denis V. , Yakushenko S. S , Koroleva M. A , Chuprov I. N , Sidikov A. A
Published: September 2020

Erythroderma represents one of the most complex problems of dermatology. First of all, it is explained by variety of reasons, a pathogenesis ambiguity, monotonous clinical picture, tendency of many forms of an erythroderma to a long and heavy current and resistance to therapy. The erythroderma doesn’t represent a certain disease, it is, most likely, clinical implication of set of various diseases. The majority of erythroderma cases described in literature have been induced by different types of medicines and dietary supplements. In English-speaking literature more than ten cases of erythroderma induced from various components of anti-tuberculous therapy are described. The first case of eryhtroderma in Russian-speaking scientific literature which appeared in five months from the beginning of anti-tuberculous therapy is presented.
THE CASE OF EPIDERMAL CYST IN A TEENAGER
Authors: Dumchenko V. V , Shashkova Alla A. , Kislitsa T. N , Petrova I. V
Published: September 2020

A case of an epidermal cyst in a fifteen-year-old girl is described. The clinical picture was characterized by the changes on the foot skin for ten months. Several surgical operations were performed. The diagnosis of the soft tissue foot abscess was established. The data on pathogenesis, clinical forms and treatment are presented.
THE RELATION BETWEEN THE CONTENT OF PERIPHERAL BLOOD NEUTROPHILS AND THE BLOOD RELEASED FROM THE SURFACE OF PSORIATIC PAPULA
Authors: Kashutin S. L , Sherstennikova Alexandra K. , Neklyudova V. S , Nikolaev V. I , Shagrov L. L , Klyuchareva S. V , Piryatinskaya V. A
Published: September 2020

The functional capabilities of neutrophils go beyond the traditional understanding, as phagocytic cells. There are evidences that show the role of neutrophils in antigen presentation to monocytes and lymphocytes, as well as the ability to regulate functions of immune cells through cytokine production. The role of neutrophils in the pathogenesis of psoriasis is not entirely clear, in this connection, the aim of our study was to examine the content ratio of peripheral blood neutrophils and the blood released from the surface of psoriatic papules with the level of expression of adhesion molecules. Material and methods. Clinical and immunological examination of 82 patients with vulgar and exudative psoriasis in the progressing and stationary stage (39 women and 43 men) aged from 20 to 60 years was carried out. Duration of the disease was from 3 months to 10 years. The control group included 50 healthy individuals (28 women and 22 men) aged from 20 to 60 years. They had no chronic diseases or aggravation. The number of neutrophils was determined on the smear of peripheral blood, as well as blood obtained from the surface of psoriatic papule, defined as a phenomenon of spot bleeding of the psoriatic triad. The content of L-selectin (CD62L, FITC), LFA-1 (CD11a, FITC), LFA-3 (CD58, FITC), ICAM-1 (CD54, FITC), L-selectin was measured on a flow cytometer FC-500 from Beckman Coulter (USA) PECAM-1 (CD31, FITC) on neutrophils of venous blood. Results. In venous blood of patients with psoriasis, the number of 2- and 3-segment forms of neutrophils increased statistically significantly in comparison with the control group, but the concentration of neutrophils with 4 or more segments in the nucleus decreased. In the psoriatic papule, the concentration of neutrophilic leukocytes was significantly reduced in comparison with peripheral blood, while in the segmentogram the predominant 2-segment forms of neutrophils were found. In venous blood, in psoriasis patients a statistically significant decrease of neutrophils with a PECAM-1 molecule was revealed, with which the final phase of transmigration into the tissue is connected. Discussion. Thus, in patients with psoriasis a statistically significant increase in the number of 2-segmetrix neutrophil forms indicates their stability in the lesion
EXPRESSION OF NUCLEAR MATRIX METALLOPROTEINASE-2 IN PATIENTS WITH CUTANEOUS MELANOMA DEPENDING ON THE AVAILABILITY OF MUTATIONS IN THE PPP6C GENES
Authors: Aksenenko Maria B. , Ruksha T. G
Published: September 2020

Material and metods. Tumor samples from paraffin blocks of melanoma patients obtained from Krasnoyarsk Territorial Oncologic Center were used in the study. Skin tissue samples (n = 40) were received from the Krasnoyarsk Territorial Pathological Anatomy Bureau. The mutation in the exon 7 of the PPP6C gene was determined by the Sanger sequencing method using specific primers. Immunohistochemistry was performed based on a standard technique using primary anti-matrix metalloproteinase-2 antibodies. Results. Mutations in the gene PPP6C were detected in 12.5% of patients; in all patients with mutation, missense mutations were observed: G266R, I271N, P259H, and a combination of two mutations in the hot spots of the P259L and R264L gene were also determined. It was found that the expression of MMP-2 in patients with a PPP6C mutant tumor type was not similar to a wild type tumor patients (p = 0.72). The predominant expression of nuclear MMP-2 is observed in PPP6C-negative patients, while in patients with mutations in the PPP6C gene, the cytoplasmic expression of MMP-2 was predominant (p = 0.045). We also found a predominance of nuclear MMP-2 expression, as a prognostically unfavorable factor, for patients in the PPP6C of negative group. Both of these facts may be related to the fact that this mutation does not affect other signaling mechanisms not associated with the BRAF and NRAS genes, nor does it directly affect the expression pattern of MMP-2.
TREATMENT OF POSTOPERATIVE SCARS WITH COMBINED USE OF CO2 LASER ABLATION AND AUTOLOGOUS PLATELET ENRICHED PLASMA
Authors: Olisova Olga Yu. , Avagyan D. V
Published: September 2020

In modern dermatology and cosmetology, the task of developing a complex method of therapy for the symptomatic complex remains acute, despite a large number of studies on this problem. The effectiveness of the treatment of postoperative scars was evaluated by the combined use of laser ablation (ablative photothermolysis) on the SmartXide Dot (Deka) device and autologous platelet enriched plasma (auto-OTP). The result of treatment of a patient with clinical manifestations of atrophic and hypertrophic postacne scarring 4th grade (according to the scorecard scale of post acne D. Goodmantal, 2006) on the skin of the face and back is presented. The tactics of managing the patient during rehabilitation after combined use of laser ablation and auto-OTP with application of topical retinoids are described. As a result of the therapy, there were fewer clinical manifestations of atrophic scars on the face skin on 70-80% and mainly hypertrophic scars on the skin of the back on 50-60%.
A RANDOMIZED STUDY OF THE SAFETY AND EFFECTIVENESS OF PRODUCTS BASED ON STABILIZED HYALURONIC ACID FOR THE CORRECTION OF INVOLUTIONAL CHANGES IN FACE AND NECK
Authors: Zakirova Gulya Sh. , Gubanova E. I , Gladko V. V , Vavilova A. A , Ilina I. V
Published: September 2020

According statistics, fillers occupy a leading position among non-surgical procedures. Despite their diversity in Russia, the evidence base for the treatment of age-related changes in the skin according to number of clinical and instrumental methods in the diagnostic is not enough. The combination of hyaluronic acid (HA) injections with fillers is pathogenetically justified. Therefore the search for scientifically based protocols for the correction of skin ageing is an actual trend in cosmetology and dermatology. Purpose. To assess the safety and effectiveness of correction of involuntary changes in face and neck skin with drugs based on stabilized hyaluronic acid. Material and methods. 35 women aged 30-65 years were enrolled into two groups by simple randomization. Group I received monotherapy with HA fillers, patients of group II - complex rejuvenation therapy for face and neck: fillers and course of vitalization stabilized HA. The efficasy was assessed according to the Global Aesthetic Improvement Scale (GAIS) on the 1st(M01), 2nd (M02), 3rd (M3), 6th (M06) month of complex therapy instrumental methods (cutometry, corneometry). Safety was assessed during 12 months of follow-up and ultrasound examination of the facial soft tissues. Results. The safety and efficacy injections of stabilized HA have been clinically confirmed. The advantages of complex therapy of fillers and the course of vitalization are shown
GENERALIZED ARGINIA
Authors: Krivosheev Alexander B. , Khvan L. A , Bobokhidze D. N , Krivosheeva I. A , Morozov D. V , Artyushin V. A
Published: September 2020

A brief review of literature on the problem of argyria is presented. Hyperpigmentation of the skin in 10-20% of cases has an iatrogenic cause. Hyperpigmentation of the skin can form on the background of taking non-steroidal anti-inflammatory drugs, amiodarone, cytostatics, antimalarials, etc. Systemic deposition of silver in various organs and tissues is known as generalized argyria. The disease is caused by the prolonged use of compounds containing silver (lapis pencil, silver nitrate, etc.). Clinically, generalized arginia is characterized by the gradual appearance of ashy-bluish coloration of the skin of open areas of the body (face, neck) and nail plates of the phalanges of the hands. The period from the moment of the beginning of reception of preparations of silver and before occurrence of the first dermatological changes varies on the average from 1 year to 5 years. Generalized argiria is a rare disease. This is due to the limited use of silver drugs in clinical practice, as well as the improvement of technological processes in pharmacological production. The patient’s own observation with generalized arginia formed against the background of the long-term administration of the drug Argovit-S, whose silver content is 0.75-0.85 mg/ml, is analyzed. The patient took the drug alone as a food supplement for 25 years. The diagnosis of generalized arginia is verified clinically, but is confirmed necessarily in the course of histological examination. It is shown that argyria is not only the iatrogenic cause of skin hyperpigmentation, but a serious risk factor for the manifestation and progression of liver cirrhosis. Patients with generalized arginia should undergo a comprehensive examination in order to verify the serious pathology of internal organs.
MORPHOLOGICAL CHARACTERISTICS OF EPIDERMIS AND DERMIS IN PATIENTS WITH DIFFUSE ALOPECIA, ANDROGENETIC ALOPECIA AND ALOPECIA AREATA
Authors: Kashutin S. L , Tedder E. I , Shagrov Leonid L. , Shutskiy N. A , Nekludova V. S , Korolev K. K , Aristov D. E
Published: September 2020

Despite the emergence of non-invasive and very informative techniques, such as trichoscopy and confocal microscopy, it is still necessary to use a skin biopsy of the scalp. Currently, there is a lot of information about hystopathology of the scalp in patients with diffuse alopecia, androgenetic alopecia and alopecia areata [1]. Researches mostly aim to study the follicular unit, whereas data on pathological changes in the epidermis, papillary and reticular dermis in the above-mentioned alopecia are rare and scattered. In this connection, the aim of the research was to study morphological characteristics of epidermis and dermis in patients with diffuse alopecia, androgenetic alopecia and alopecia areata. Material and methods. We examined 25 patients (12 women and 13 men) aged 17 to 60 years with not cicatricial alopecia: androgenetic alopecia was observed in 10 patients, alopecia areata - in 9 patients, diffuse alopecia - in 6 patients. The age of the disease ranged from 1 month to 5 years. The control group consisted of 9 people. The review microscopy and morphometry of samples, taken for investigation, were performed using the eyepiece micrometer MOB-1-15xУ4.2. The following indicators in the dermis were evaluated: the presence of lymphohistiocytic infiltrates in the papillary and reticular dermis, mucoid swelling of sclerosis of the papillary dermis, and signs of destruction of hair follicles. Results. The tendency to increase thickness of the epidermis in patients with diffuse alopecia is associated with thickening of the stratum granulosum and especially the stratum corneum. In case of androgenetic alopecia and alopecia areata the tendency to decrease the thickness of the epidermis is associated with a tendency to reduce the thickness of the stratum lucidum. Regardless of the type of alopecia, the thickness of the stratum basale is statistically higher than in the control group. Regardless of the type of alopecia, changes in the dermis are manifested by the destruction of hair follicles followed by the presence of lymphohistiocytic infiltrates in the papillary and reticular dermis, as well as sclerosis of the papillary dermis. Discussion. It can be anticipated that the presence of lymphohistiocytic infiltrates in the papillary and reticular dermis may indicate the inflammatory process, which is accompanied by abnormal microcirculation and the destruction of the hair follicle which in turn insufficiently stimulates angiogenesis.
ACROKERATOELASTOIDOSIS COSTA: REVIEW OF LITERATURE AND DESCRIPTION OF THE CLINICAL CASE
Authors: Ufimtseva M. A , Bochkarev Yu. M , Nikolaeva K. I , Akulova S. A
Published: September 2020

The review of literature and clinical case of an acrokeratoelastoidosis Costa as rare form of a focal keratodermiya is presented in article. This dermatosis is characterized by symmetric hyperkeratical papular eruptions, settling down mainly on the lateral surfaces of palms and soles. Acrokeratoelastoidosis it is necessary to differentiate both with hereditary limited keratodermiya, and with a widespread infectious skin disease - viral warts that is important at inspection on medical examinations of persons the decreed groups. The patient sent from preliminary medical examination at employment to preschool institution at whom originally rashes have been taken for display of multiple palmar and plantar viral warts is described.
DOUBLE PORPHYRIA: LITERATURE REVIEW AND ANALYSIS OF CLINICAL OBSERVATION
Authors: Krivosheev Alexander B. , Kupriyanova L. Ya , Kondratova M. A
Published: September 2020

A brief review of the literature on the problem of double porphyria and analysis of its own observation is presented. For more than 10 years patient B was observed for more than 10 years with a verified diagnosis of acute intermittent porphyria, which manifested with acute pain abdominal syndrome, neurological disorders in the form of peripheral polyneuropathy and hemiparesis of lower extremities, and hypertension syndrome was also noted. The observed clinical symptoms corresponded to an acute porphyrin crisis in the manifestation and / or relapse of acute intermittent porphyria. The diagnosis was confirmed by a quantitative determination of the excretory profile of porphyrin precursors (δ-aminocaproic acid, porphobilinogen) and porphyrin fractions (uroporphyrin, coproporphyrin). Their concentrations are significantly (especially porphyrin precursors) exceeding the control values, which is the cardinal diagnostic criterion of acute intermittent porphyria. Against the backdrop of persistent clinical and biochemical remission of acute intermittent porphyria, symptoms of photosensitization of the skin (blisters, erosion, pigment spots) on the dorsal surface of the hands began to appear in 4 years. Later, hypertrichosis was formed in the temporo-periorbital region. The constellation type of the excretory profile of porphyrins began to change. Against the backdrop of persistent increased excretion of porphyrin precursors (δ-aminolevulinic acid and porphobilinogen), a progressive increase in the excretion of the fraction of uroporphyrin was observed, which became dominant (up to 58% of the total content of porphyrins). Such a prolonged observation in the dynamics allowed us to state the appearance of a new variant of the porphyrin exchange disturbance, which, taking into account clinical symptoms, corresponded to another form of hepatic porphyria, namely, late cutaneous porphyria. The clinical and biochemical changes in the excretory profile of the parameters of porphyrin metabolism registered in the dynamics of observation may indicate the occurrence of a combined enzymatic defect characteristic of double porphyria. In our case, a manifestation of late cutaneous porphyria was noted against a background of compensated acute intermittent porphyria.
FEATURES OF EXPRESSION OF KI-67 AND NFE2L2 IN TARGET ORGANS OF MELANOMA METASTASIS IN PREMETASTATIC PHASE
Authors: Sergeeva O. N , Palkina N. V , Aksenenko M. B , Komina A. V , Sergeeva E. Yu , Ruksha Tatiana G.
Published: September 2020

Tumor microenvironment is known to be an active participant of tumor development. Tumor microenvironment is functional cell community interacting with cancer cells and promoting proliferation, invasion and metastasis of tumor cells. In the article features of Ki-67 and NFE2L2 expression levels in target organs of melanoma metastasis in premetastatic phase are investigated. Increased Ki-67expression levels in lung tissue, liver and kidneys and decreased NFE2L2 levels in liverandkidneys can be the markers of structural and functional reorganization of melanoma metastasis target organs in premetastatic phase of melanoma development.
CLINICAL AND EPIDEMIOLOGICAL FEATURES OF HERPES ZOSTER IN TAJIK REPUBLIC
Authors: Isaeva M. S , Mirzoeva Munira T. , Olisova O. Yu , Kochergin N. G
Published: September 2020

Herpes zoster (HZ) is one of the common viral skin disease with typical clinical picture and well known etiology and pathogenesis. Epidemiological and clinical peculiarities and differences of herpes zoster in different ethnic groups and geographical regions still present a field of special interest. The aim of this work was to investigate clinically HZ in Tajikistan republic. The male predominance (57.8% and 42.2%) was found as well as the higher level of the disease in urban aeries comparing to rural ones (66.7% and 33.3%). The most frequent clinical forms of HZ in Tajik population were erythematose and vesicular (63.3%), hemorrhagic (21.1%) and bullouse form (15.6%). Conclusion: the high level of severe hemorrhagic and bullouse forms of HZ and the disease predominance among urban population are characteristic for patients in Tajik Republic.
The application of aquatherapy in the programs for the rehabilitation of the patients following a previous cardiovascular diseases
Authors: Persiyanova-Dubrova A. L , Badalov Nazim G.
Published: September 2020

The present study was designed to evaluate the possibilities for the application of aquatherapy in the framework of the therapeutic and health promotion programs. Although the relevant investigations are small in number, their results indicate that aquatherapy provides a powerful tool for the prevention of the cardiovascular diseases (CVD) and the rehabilitation after recovery from this pathology. Under certain conditions, this therapeutic modality is the method of choice for the treatment of a specific group of patients either in combination with the aerobic activity or as an alternative to it. The recognition of the importance of aquatherapy and its further development require the extension and the modification of the currently available scientifically sound evidence base.
The state of the thymus and bone marrow in the rats following laser irradiation of the skeletal muscles and physical load on the irradiated animals
Authors: Bulyakova Nelli V. , Azarova V. S
Published: September 2020

We have evaluated the state of the skeletal muscles, thymus, and bone marrow before and after laser irradiation of the rats and following the physical load on the irradiated animals. In the first experiment, both hind limbs of each rat in the region of projection of gastrocnemius muscles were subjected to 5 sessions of infrared laser irradiation at a dose of 11.70-12.60 J/sq.cm during 12 days with the use of a He-Ne laser. In the second experiment, the similarly irradiated rats were subjected to physical load in the form of swimming during 30 minutes. The histological, morphometric, cytological, and cytogenetic analysis have demonstrated that the muscle mass of the animals involved in the two experiments did not change. At the same time, laser irradiation caused the impairment of the function of the thymus and bone marrow. This effect was even more pronounced when the animals underwent the combined influence of laser irradiation and physical load. The ana-telophase assay revealed a rise in the number of cells with aberrant mitoses in the two organs of the immune system. It is concluded that in order to reduce the possible unfavourable consequences of laser therapy for the skeletal muscles preceding the physical load/training, it is necessary to choose the optimal dose of radiation and develop a sparing regime of laser irradiation taking into consideration the initial state of the organism.
The spa and health resort-based treatment of the patients presenting with metabolic disturbances and toxic hepatic lesions
Authors: Efimenko N. V , Ledovskaya T. I , Kaisinova Agnessa S. , Fedorova T. E
Published: September 2020

The objective of the present study was to develop the methods for the spa and health resort-based treatment of the subjects employed at the chemical industry enterprises and suffering from metabolic disturbances and toxic hepatic lesions. A total of 76 patients at the mean age of 48,8 ± 5,7 years presenting with these problems were available for the examination. The patients were given the routine spa and health resort-based treatment supplemented by the consumption of the Essentuki-type drinking mineral waters, dalargin magnetic electrophoresis applied to the abdominal region, and the use of the biologically active additives (Metabolit Plus). This treatment as found to facilitate the improvement of the clinical, biochemical, hormonal, immunological, and hemodynamic characteristics of the patients’ condition. In addition, it promoted normalization of lipid peroxidation in the patients presenting with metabolic disturbances and toxic hepatic lesions.
The use of the knee joint replacement prosthesis after the amputation at the level between hip and knee
Authors: Prokopenko R. A
Published: September 2020

This review was designed to characterize the current state-of-the-art of knee joint replacement prosthetics with respect to the cases of the amputation at the level between hip and knee. Various types of knee joint modules are compared. The clinical and biomechanical methods are described that are employed to evaluate the effectiveness of the movements of the disabled patients following the amputation at the level between hip and knee.
The importance of prolactin for the evaluation of the effectiveness of the spa and health resort-based treatment of gynecological diseases
Authors: Boldyreva Ol’ga A. , Kaladze N. N
Published: September 2020

The objective of the present study was to evaluate the influence of peloid therapy on the dynamics of clinical and hormonal characteristics of the women presenting with bacterial vaginosis (BV) and accompanying chronic inflammation of the small pelvis organs depending on the initial prolactin (PRL) level. A total of 186 women with this pathology underwent the examination under conditions of a spa and health resort facility for the elucidation of their clinical symptoms and parameters of hormonal regulation. The patients were divided into two groups. Group 1 was comprised of 128 women suffering from BV and having the normal PRL level. Group 2 consisted of 58 women with bacterial vaginosis in combination with hyperprolactinemia (HP). We undertook the dynamic assessment of the clinical and laboratory findings before and after peloid therapy given to the patients of both groups. It was shown that the application of the silt-sulfide therapeutic muds for the treatment of bacterial vaginosis in the women with the normal prolactin level facilitates the formation of positive clinical dynamics, modulates secretion of pituitary hormones, and stimulates the functional activity of both the adrenal glands and the ovaries. Peloid therapy of the women presenting with BV and HP caused the further aggravation of hormonal disbalance as a result of enhancement of the initial PRL level and discoordination of the hypophyseal-ovarian component of the hormonal regulation system; taken together, these effects thereby impaired the effectiveness of the treatment. The results of the study indicate that the level of prolactin can be used as a marker of the effectiveness of the spa and health resort-component of the combined treatment of gynecological diseases. It is concluded that the prescription of such treatment including peloid therapy to the women suffering from these pathologies must take into consideration the initial parameters of hormonal regulation and the presence of hyperprolactinemia.
Correction of arterial hypertension in the young patients with obesity
Authors: Luk’janov V. F , Raigorodskiy Yuri Mikhailovich , Bolotova N. V , Posokhova N. V
Published: September 2020

The study included 90 patients with obesity I-III and arterial hypertension (AH) I of 16-30 years. Evaluated lipid and carbohydrate metabolism, the condition of the autonomic nervous system, circadian blood pressure, pulse wave velocity in the aorta (PWV), and the effectiveness of the running magnetic field with the help of apparatus «MAGNETIC SIMPATOKOR» in order to reduce blood pressure (BP). The patients were divided into 2 groups: basic - 50 people who underwent magnetic simpatokorrektsiya and control - 40 people received placebo physiotherapy. According to a survey in the group allocated to two subgroups - 1A and 1B. Subgroup 1A amounted to 26 patients with hypersympathicotonia who at repeated definition SPV after simpatokorrektsii noted its significant reduction. In the subgroup 1B included 24 patients with a normal tone and parasimpatikotoniey who SPV has not changed much. After 6 months in patients subgroups 1A BP was on normal numbers, DBS remained at baseline values. In the subgroup 1B patients remained elevated blood pressure. The risk of developing hypertension in a subgroup 1A was 22% in the subgroup 1B - 80% or more. Sympathy correction using magnetic field exposure on the cervical sympathetic ganglion is an effective treatment and prevention of hypertension associated with increased activity of the sympathetic nervous system.
The effectiveness of transdermal electrical stimulation used to treat neuropathic and metabolic disorders in the patients with diabetes mellitus
Authors: Lazarenko Nina Nikolaevna , Smirnova S. N , Trunova O. V , Supova M. V , Prikuls V. F , Filatova E. V , Pankova I. A , Smirnov A. E , Gerasimenko M. Yu
Published: September 2020

World-wide occurrence of diabetes mellitus and its complications in the form of neuropathic and metabolic disorders implies the necessity of development and application of the new methods for their combined treatment, such as the low-frequency transdermal electrical stimulation with the use of the OMRON Е-4 myostimulator. This technique was shown to significantly alleviate the symptoms of pain syndrome and other neuropathic manifestations. Moreover, it facilitated the reduction of body weight and visceral fat content in such patients and thereby considerably decreased the risk of development of diabetic complications.
Local narrow-band (311 nm) phototherapy of palmar-plantar psoriasis in the children
Authors: Turbovskaya Svetlana Nikolaevna , Kotenko K. V
Published: September 2020

The objective of this article was to report the data concerning the local application of narrow-band (311 nm) phototherapy in the children presenting with palmar-plantar psoriasis. It is concluded that local narrow-band phototherapy using ultraviolet radiation with a wavelength of 311 nm is an efficient method for the treatment of this condition in the children.
Palmarplantar erythrodysesthesia in the patients with oncological pathology treated with multikinase inhibitors and the method for its correction
Authors: Kruglova L. S , Shatokhina Evgeniya Afanas’evna , Kotenko K. V
Published: September 2020

Introduction. The modern anti-tumour preparations from the group of multikinase inhibitors exhibit the high clinical effectiveness. Courses of therapy with such medications are indispensable and vitally important for the treatment of the patients presenting with oncological pathology but, unfortunately, happen to give rise to the development of a toxic reaction in the form of рalmar-plantar erythrodysesthesia which not infrequently prevents the completion of the full-scale treatment. The determination of the adequate skin condition is an indispensable component of the combined treatment of the oncological patients. Materials and methods. The present study included 9 patients treated with various preparations from the group of multikinase inhibitors. All of them developed toxic cutaneous reactions in the form of grade II-III palmar-plantar erythrodysesthesia which was corrected with the use of thioctic acid-based preparation at a daily dose of 600 mg given during 14 days in the combination with pharmaphoresis of the cream containing 0.1% of betamethasone valerate. Results. The use of the proposed therapeutic modality resulted in the reduction of the severity of the clinical manifestations of palmar-plantar erythrodysesthesia, such as erythema, infiltration, desquamation, fissures, etc. Simultaneously, the treatment eliminated certain subjective symptoms including pruritus, pain, and paresthesia. Taken together, these effects significantly improved the patients’ condition and allowed the course of antitumour therapy to be totally completed. Conclusion. The patients presenting with palmar-plantar erythrodysesthesia should be managed with the use of multikinase inhibitors in the combination with the oral administration of a thioctic acid-based preparation and local pharmaphoresis of the cream containing 0.1% of betamethasone valerate.
The modern possibilities and prospects of physiotherapeutic and balneotherapeutic methods for the treatment and rehabilitation of the patients with diabetic neuropathy
Authors: Marchenkova Larisa Aleksandrovna , Badalov N. G , Gerasimenko M. Yu , Martynova E. Yu
Published: September 2020

Diabetic neuropathy is the most widespread late complication of diabetes mellitus that considerably deteriorates the quality of life of the patients. The treatment of diabetic neuropathy is a difficult task requiring the multidisciplinary approach that can be adequately resolved by means of the pathogenetically substantiated combined application of the pharmacotherapeutic and drug-free modalities. The article presents the overview of the data suggesting the high effectiveness of the main physiotherapeutic and balneotherapeutic methods for the treatment and rehabilitation of the patients presenting with diabetic neuropathy as well as the prospects for their future applications.
PHYSICAL THERAPY IN THE PATIENTS PRESENTING WITH ESSENTIAL HYPERTENSION: THE SCIENTOMETRIC ANALYSIS OF EVIDENCE-BASED RESEARCH
Authors: Kovlen D. V , Ponomarenko G. N
Published: September 2020

This article presents the current data on the scientometric analysis along with the prospects for the implementation of the evidence-based approach to the development of the strategy for physical therapy of essential hypertension. Aim. The objective of the present work was the scientometric analysis of the results of the evidence-based studies concerned with the application of the medical physical factors for the treatment of essential hypertension. Results. The results of a detailed analysis of the clinical effects and the putative mechanisms of action of evidence-based medical physical factors in the treatment of essential hypertension are presented. Much attention is given to evidence-based research of the use of dosed physical activity, remedial gymnastics, instrumental methods, and artificial medical physical factors for the treatment of the patients suffering from different clinical forms of essential hypertension. The data obtained in this study provided a basis for the development of the clinical guidelines for the evidence-based application of the medical physical factors in the treatment of hypertensive patients. Conclusion. The regular generalization and analysis of the on-going evidence-based research as well as the conduction of the new high-quality randomized controlled clinical trials are needed to evaluate the effects of natural and artificial medical physical factors on the patients presenting with essential hypertension.
THE APPLICATION OF THE NON-DRUG TECHNOLOGIES FOR THE MEDICAL REHABILITATION OF THE PATIENTS PRESENTING WITH CHRONIC GENERALIZED PERIODONTITIS
Authors: Khaybullina Rasima R. , Gilmutdinova L. T , Gerasimova L. P , Khaybullina Z. R
Published: September 2020

The article is devoted to the problem of medical rehabilitation of the patients presenting with periodontal pathologies with the use of drug-free technologies. The results of the comprehensive examination, diagnostics, and treatment of 69 patients with mild chronic generalized periodontitis and 115 patients suffering from chronic generalized periodontitis of moderate severity are presented. The methods for the combined treatment of the patients with mild and moderately severe chronic generalized periodontitis were developed based on the application of the non-drug technologies. The effectiveness of the complex treatment was evaluated. The study has demonstrated positive dynamics of the patients’ conditions manifested as the decrease of the index of hygiene by 43.0 ± 0.3%, the index of bleeding by 52.0 ± 0.06%, and the gingival index by 49.00± 0.08%. The effectiveness of the treatment increased in the patients who received the basal treatment supplemented by a complex of natural components.
THE EFFECTIVENESS OF A NEODYMIUM (1064 NM) LASER AND FRACTIONAL PHOTOTHERMOLYSIS FOR THE CORRECTION OF THE ATROPHIC SCARS
Authors: Talybova A. P , Sten’ko Anna Germanovna
Published: September 2020

One of the challenging problems for modern cosmetology is the cosmetic correction of the cutaneous scars of the skin that arises in the first place from the high prevalence of this condition and the lack of reliable and safe methods for its treatment The application of laser technologies including selective laser therapy as the method of fractional photothermolysis and the use of a neodymium (1064 nm) laser is considered to be a promising approach to address this problem. The present study included 18 patients presenting with hormone-dependent atrophic scars. All the patients were assigned for the treatment by selective photothermolysis (at the rate of 2 sessions per each treatment course performed with a 4 week interval) and irradiation by the neodymium laser (at the rate of 6-8 sessions conducted after fractional photothermolysis). The use of combined laser therapy in patients with hormone-dependent atrophic scars produced a pronounced effect as evidenced by the improvement of the clinical picture and was accompanied by the 78.1% reduction of the symptom index according to the DISC symptom scale and the 76.5% improvement of the dermatology life quality index (DLQI). The use of the combined method for the correction of atrophic cutaneous scars helps to restore the epidermal-dermal and epidermal structures of the skin in the association with the 1.4-fold, 1.7-fold, and 1.6-fold increase in the thickness of the epidermis, dermis, and hypodermis respectively; simultaneously, the acoustic density of the tissues increased by 1.8 times which corresponded to the improvement of the ultrasound picture by almost 75% when estimated in accordance with the Vancouver scar scale.
USE OF PHYSIOTHERAPEUTIC METHODS AT DIFFERENT STAGES OF REHABILITATION OF THE CHILDREN SUFFERING FROM ATOPIC DERMATITIS
Authors: Koroleva T. V , Murashkin N. N , Kotenko K. V
Published: September 2020

Atopic dermatitis remains a serious medical and social problem, especially in adolescents. The further development of rehabilitative and physiotherapeutic modalities and their extensive introduction into the clinical practice during the periods of remission make it possible to reduce to a minimum the duration of the oral and topical therapy and thereby to decrease the risk of adverse side effects, improve the quality of life of the patients suffering from atopic dermatitis, and prolong the inter-recurrence periods. The present study included 44 children at the age 15-18 years suffering from atopic dermatitis of mean duration 14.1 ± 1.5 years. They remained under the observation for 48 weeks. The frequency of exacerbations in most of these children (81.8%) was estimated at 4.7 ± 0.8 times a year, with the majority of acute episodes falling on the cold seasons. In 84.1% of the children, the loading coefficient for concomitant somatic diseases was 2.9. All the children received the comprehensive pharmacotherapy and physiotherapeutic treatment in the period of the last exacerbation including transcerebral pulsed electrical therapy, magnetic laser therapy and/or their combination. The study has demonstrated that the use of methods mentioned above during the period of remission in children with atopic dermatitis increased the adaptive potential of the organism, strengthened the general health status of the patients, contributed to the reduction in the frequency and severity of exacerbations of the pathological processes affecting the skin.
THE INFLUENCE OF LIGHT OF VARIOUS WAVELENGTHS ON THE MORPHOFUNCTIONAL CONDITION OF SKIN EXPOSED TO EXPERIMENTAL DERMATITIS
Authors: Schastnaya Nadezhda Ivanovna , Kuznetsova T. E , Ryzhkovskaya E. L , Ulaschik V. S
Published: September 2020

The influence of optical radiation of various spectral ranges on the morphofunctional state of the skin under conditions of experimental dermatitis was studied. It was demonstrated that the effectiveness of the light depends on the radiation wavelength. The clinical, histochemical, and morphological data obtained give evidence that the application of blue and red optical radiation to the skin affected by experimental dermatitis is likely to produce the most pronounced therapeutic effect.