bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Combination Method of N-doped TiO2 Nanoparticles Synthesis for Heavy Metal Ions Cr(VI) Photoreduction Applications
Authors: Wellia Diana Vanda , Habibillah M. Rafli , Syafawi Atika , Rahmadini Rizka , Rahmayeni Rahmayeni , Pratiwi Nurul
Published: April 2023

Through a combination of biosynthetic and hydrothermal methods, N-doped TiO2 photocatalyst has been successfully synthesized using various concentrations of ammonia as a nitrogen source, namely 10% w/w (NTO10), 20% w/w (NTO20), 35% w/w (NTO35), and 50% w/w (NTO50). The synthesis of TiO2 was conducted using Aloe vera (L) Burm F. rind extract as a natural capping agent via the biosynthetic method, followed by a nitrogen doping process via the hydrothermal method. The X-ray Diffraction (XRD) analysis revealed that all phases were anatase. According to the results of the UV-Vis Diffuse Reflectance Spectroscopy (UV-Vis DRS) analysis using the Tauc-Plot method, all N-doped TiO2 samples showed a decrease in the energy gap compared to the TO sample. This indicates that the doping of TiO2 using nitrogen has been successfully doped into TiO2. The photocatalytic activity of N-doped TiO2 was evaluated for the photoreduction of the Cr(VI) model pollutant using a 24-watt LED lamp as a visible light source for 120 minutes. The results indicate that the NTO35 is the best-prepared N-doped TiO2, which showed a reduced rate for the Cr (VI) model pollutant of 50.88%, or two times greater than that of undoped TiO2.
Influence of interphase characteristics on the elastic modulus of unidirectional glass-reinforced epoxy composites: a computational micromechanics study
Authors: Shubham  , Prusty Rajesh Kumar , Ray Bankim Chandra
Published: April 2023

This article briefly discusses the role of interphase in the elastic moduli of unidirectional fiber-reinforced polymer composite materials. For this unidirectional glass fiber was chosen as reinforcement, and epoxy was selected as the matrix. A hexagonally packed representative volume element is used for the micromechanical analysis. Experimental validation was initially used to verify the accuracy of the established equations of the rule of mixing, Composite Cylinder Assemblage, Chamis, Halpin and Tsai, and Puck. The Chamis equation was found to be the most reasonable. Then the finite element approach in which interphase has been included was used to estimate the elastic moduli. The finite element model without interphase and the experimental result were taken as a reference. The influence of interface ratio and property of interphase on the homogenised elastic properties of the unidirectional fiber-reinforced polymer composites is analysed. A micromechanics plugin in Abaqus software was used to estimate the density and Young’s modulus of the unidirectional fiber-reinforced polymer composites. The interphase properties are varied, having 6.25%, 12.5%, 25% and 50% influence of the fiber phase and the remaining influence of the matrix phase with interface ratios of 0.1, 0.2 and 0.3. The interface ratio of 0.3, having 6.25% fiber phase influence, gave the most reasonable moduli values (with an error <10%) compared to the mean experimental moduli. The study showed interface ratio and interphase properties to critically influence the overall elastic property of the unidirectional fiber-reinforced polymer composites.
Adopting online flipped teaching to improve learner engagement in an English for specific purposes (ESP) course in China: a mixed-methods study
Authors: Li Zhiyong , Wang Yang
Published: April 2023

In this study, we evaluated the effect of online flipped teaching on learner engagement in an English for specific purposes (ESP) listening and speaking course at a Chinese university. We also aimed to understand the factors influencing learner engagement in an online environment. For this study, an e-learning platform called Yunbanke was used for asynchronous teaching in a flipped class, and Tencent Meeting was employed for synchronous teaching in the non-flipped and flipped class, respectively. We used a mixed-methods approach. First, we conducted a quasi-experiment to compare engagement levels between the experimental group (flipped class, n = 34) and control group (non-flipped class, n = 35) before and after 16 weeks of online instruction. Then, we used lesson logs and conducted interviews with the students and the instructor. The results showed that online flipped teaching could significantly improve the learners’ behavioural and cognitive engagement compared to the non-flipped class. However, no significant difference was found in emotional engagement between the two classes. Qualitative data supported our quantitative findings, and five key factors leading to different dimensions of learner engagement were identified: learners’ prior English attainment, learners’ perceived affordance of online learning and teaching, interpersonal factors, instructor presence and learning tasks. Our findings can shed light on online ESP learners’ engagement and improve online ESP teaching practices.
Jacobsen syndrome: Chromosome deletion at llq23
Authors: Clang Daniel R. , LaBaere II Richard J.
Published: April 2023

A male infant delivered at term to unrelated parents was found to have multiple dysmorphic facial characteristics, abnormal head shape, anemia, thrombocytopenia, a prominent holosystolic heart murmur with multiple cardiac defects, hypotonia, and was small for his gestational age. Karotype revealed a de novo deletion of the long arm of chromosome 11, del (11 )(q23), which has been previously described as Jacobsen syndrome. Recent studies have demonstrated that a folate-sensitive fragile site at 11q, band 23, (1lq23) may be responsible for this deletion and possibly other syndromes as well.
Corrosion fatigue behavior of AA 7020 alloy in seawater
Authors: Yurdgulu Halil Ibrahim , Sadeler Recep , Yilmaz Hasan , Koc Baris
Published: April 2023

The effect of two-step aging treatment on the fatigue behavior of welded AA 7020 Al. alloy was investigated. For fatigue tests to be carried out in atmospheric and seawater environments, a plane bending tester at a stress ratio of R = 0 was used. Experiments in the control group were carried out with unwelded specimens at a strain rate of R = −1 in air. The gradual heat treatment, two-step aging, significantly improved the fatigue and corrosion fatigue behavior of welded AA 7020 alloys. Unwelded specimens showed better fatigue properties than the welded ones. In the experiments in the seawater environment, pitting, and exfoliation corrosion occurred on the surfaces. It was determined that the corrosion pits reduce the fatigue life of welded and unwelded specimens. It was also observed that the corrosion sensitivity of the welded specimens increased in the heat affected zone and resulted in corrosion fatigue cracking.
Synthesis of SnO2 nanoparticles coated ZnO–g–C3N4 composite nanostructures with novel antibacterial activity
Authors: Hussain Shah Muhammad Baqar , Mansoor Qaisar , Jan Tariq , Farooq Zahid , Ilyas Syed Zafar
Published: April 2023

In this work, composite nanostructures (CNs) of SnO2–ZnO–g–C3N4 have been prepared by a soft chemical method and investigated for their potential application in photocatalytic remediation of organics in water and antibacterial agents. Structural study revealed the presence of three phases related to hexagonal wurtzite phase of ZnO, tetragonal phase of SnO2 and monoclinic phase of g–C3N4 having nanocrystalline nature which confirms the formation of CNs. Formation of nanoscale morphology along with elemental composition of the CNs have been validated through scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) spectroscopy. The presence of only A
1g mode of SnO2 in Raman spectrum of ternary CNs suggested that SnO2 nanoparticles have been coated on the surfaces of ZnO and g–C3N4 which is also evident from SEM results. SnO2–ZnO–g–C3N4 CNs have shown much higher photocatalytic degradation efficiency and produced 7 mm greater zone of inhibition (ZOI) against Gram-positive S. Aureus bacteria as compared to pure ZnO which is quite significant result when compared to previously reported results for SnO2–ZnO CNs. These synthesized CNs may have potential uses in healthcare technology and treatment of organics in water.
Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy
Authors: Cusinato Riccardo , Alnes Sigurd L. , van Maren Ellen , Boccalaro Ida , Ledergerber Debora , Adamantidis Antoine , Imbach Lukas L. , Schindler Kaspar , Baud Maxime O. , Tzovara Athina
Published: April 2023

During rest, intrinsic neural dynamics manifest at multiple timescales, which progressively increase along visual and somatosensory hierarchies. Theoretically, intrinsic timescales are thought to facilitate processing of external stimuli at multiple stages. However, direct links between timescales at rest and sensory processing, as well as translation to the auditory system are lacking. Here, we measured intracranial electroencephalography in 11 human patients with epilepsy (4 women), while listening to pure tones. We show that in the auditory network, intrinsic neural timescales progressively increase, while the spectral exponent flattens, from temporal to entorhinal cortex, hippocampus, and amygdala. Within the neocortex, intrinsic timescales exhibit spatial gradients that follow the temporal lobe anatomy. Crucially, intrinsic timescales at baseline can explain the latency of auditory responses: as intrinsic timescales increase, so do the single-electrode response onset and peak latencies. Our results suggest that the human auditory network exhibits a repertoire of intrinsic neural dynamics, which manifest in cortical gradients with millimeter resolution and may provide a variety of temporal windows to support auditory processing.

SIGNIFICANCE STATEMENT:

Endogenous neural dynamics are often characterized by their intrinsic timescales. These are thought to facilitate processing of external stimuli. However, a direct link between intrinsic timing at rest and sensory processing is missing. Here, with intracranial electroencephalography (iEEG), we show that intrinsic timescales progressively increase from temporal to entorhinal cortex, hippocampus, and amygdala. Intrinsic timescales at baseline can explain the variability in the timing of iEEG responses to sounds: cortical electrodes with fast timescales also show fast and short-lasting responses to auditory stimuli, which progressively increase in the hippocampus and amygdala. Our results suggest that a hierarchy of neural dynamics in the temporal lobe manifests across cortical and limbic structures and can explain the temporal richness of auditory responses.
Long-term safety of growth hormone replacement therapy in survivors of cancer and tumors of the pituitary region
Authors: Bolier Melissa , van der Lelij Aart-Jan , Janssens Geert O , van den Heuvel-Eibrink Marry M , Neggers Sebastian J C M M
Published: April 2023

Growth hormone deficiency (GHD) is a common complication in survivors of cancer and patients with tumors of the pituitary region. Growth hormone replacement therapy (GHT) has proven beneficial effects, including increased growth velocity, positive effects on body composition and skeletal integrity, and increased quality of life. However, due to known pro-proliferative, angiogenic, and anti-apoptotic properties of growth hormone, there are still some concerns about the safety of GHT in survivors. This narrative review aims to provide an overview of the long-term sequelae, and subsequently long-term safety, of GHT in survivors of (childhood) cancer and patients with tumors of the pituitary region. We identified predominantly reassuring results regarding the safety of survivors with GHT, although we must take into account the shortcomings of some studies and limited information on adult cancer survivors. Besides the already increased risk for second neoplasms, recurrences, or mortality in survivors due to host-, disease-, and treatment-related factors, we could not identify an increased risk due to GHT in particular. Therefore, we support the consensus that GHT can be considered in survivors after careful individual risk/benefit analysis and in open discussion with the patients and their families, taking into account the known morbidity of untreated GHD in cancer survivors and the positive effects of GHT.
Analysis of the Influence of Self-Similar Traffic on Efficiency Multiple Access Protocols
Authors:   Institute of Nuclear Research of the National Academy of Sciences of Ukraine, Voiter Anatolii P.
Published: April 2023

Introduction. Traffic in modern telecommunication radio networks is self-similar, therefore, the use of methods for calculating the parameters of Carrier Sense Multiple Access (CSMA) protocols adopted in the classical theory of teletraffic, based on Poisson distribution models, leads to an underestimation of the load and stability of these protocols. Purpose. Build a mathematical model for the operation of synchronous CSMA protocols with flexible and rigid strategies in conditions of self-shaped traffic. Obtain average transmission rate equations and their comparative analysis of the results of studies of the same protocols for traffic with the Poisson distribution. Methods. The goal is achieved by creating and analyzing a mathematical model for the operation of synchronous CSMA protocols with flexible and rigid strategies under conditions of Pareto-distributing traffic. The model is described by the equations of the average protocol transfer rate, which are a function of traffic intensity and Pareto distribution parameters. Results. It has been proven that self-similar traffic has a significant impact on the stability limit of CSMA protocols and their throughput, which must be taken into account when using these protocols in radio networks with long-term dependence on traffic distribution. At the same time, there is a slight decrease in the maximum average transmission rate of CSMA protocols compared to the traffic model with the Poisson distribution. Conclusions. The proposed mathematical model of CSMA protocols with flexible and rigid strategies makes it possible to calculate the real values of the average speed, stability limit, and throughput of these protocols under conditions of self-similar traffic.
Autopsies in the United States in 2020
Authors: Hoyert Donna
Published: April 2023

This report presents information on autopsy data by age, cause, place of death, and time.
Biological and functional properties of human umbilical cord-derived lyophilized tissue-engineered matrices
Authors: Kondratenko A. A. , Kalyuzhnaya L. I. , Tovpeko D. V. , Sheveleva V. S. , Glushakov R. I.
Published: April 2023

The use of tissue-engineered products (TEP) from decellularized extracellular matrix (dECM) to treat deep skin lesions is a tissue engineering method that promotes regenerative healing. Cell-free preparations reproduce the hierarchical complexity of tissues, mimic structural, biochemical and mechanical signals that are necessary to attract cells, and are a source of bioactive molecules. The human umbilical cord biomaterial has a fetal phenotype with extra-embryonic origin, and therefore is available and has no ethical limitations in its use. The tissue engineering laboratory at Kirov Military Medical Academy developed and patented a TEP from the highly regenerative human umbilical cord in the form of matrix and hydrogel matrix. To study its regenerative potential, lyophilisates of tissue-engineered solid-state and hydrogel matrices were implanted around mini pig fullthickness wounds in vivo. The external signs of inflammatory response and the histological images of biopsy specimens from the lyophilizate implantation areas were analyzed. The effect of nutrient media, «conditioned» with lyophilizates of both matrices, on the viability and migration activity of fibroblast-like cells, isolated from mini pig skin, was investigated. The matrix lyophilisates showed good biocompatibility and bioactivity in in vitro and in vivo experiments. Implantation of the samples promoted faster formation of mature epidermis compared to the control.
On indications for repeat liver transplantation
Authors: Borovik V. V. , Tileubergenov I. I. , Gerasimova O. A. , Granov D. A.
Published: April 2023

Objective: to study the causes of graft loss and indications for repeat liver transplantation (rLT).

Materials and Methods. We studied the experience garnered from 250 orthotopic full-size cadaveric liver transplantations in 228 patients from 1998 to 2021. The severity of the patient’s condition at the time of intervention was estimated according to the MELD scale. Repeat surgeries were performed in 22 cases in 19 patients (analyzed group).

Results. Organ preservation parameters, length of stay in intensive care unit (ICU), severity of postoperative complications in primary transplantations in general and in the analyzed group did not differ significantly. The main causes of graft loss were graft arterial insufficiency (57.9%) and hepatic artery thrombosis (21%). Severe early allograft dysfunction (EAD) and primary nonfunction accounted for 10.5%, portal vein thrombosis occurred in 5%, and chronic graft rejection was noted in 5% of cases.

Conclusion. Arterial insufficiency is one of the leading causes of graft loss after liver transplantation. Early correction of arterial and biliary complications help in preserving graft viability.
Clinical case of staged treatment of combined complications of orthotopic liver transplantation
Authors: Dayneko V. S. , Osipov A. V. , Reznik O. N. , Platonov S. A. , Kiselev M. A. , Safoev M. I. , Sviatnenko A. V. , Ulyankina I. V. , Loginov I. V. , Kuzmin D. O. , Savello V. E. , Kravchuk V. N. , Demko A. E. , Kandyba D. V. , Manukovsky V. A.
Published: April 2023

Hepatic artery thrombosis (HAT) following liver transplantation (LT) is a severe life-threatening complication that can lead to graft loss and mortality after LT. According to different reports, HAT incidence ranges from 2% to 9%. Modern endovascular and radiosurgical techniques allow for minimally invasive liver graft revascularization. Nonetheless, a major consequence of even a successful revascularization is ischemic cholangiopathy, which can lead to ischemic biliary strictures and anastomotic leak. The paper presents a clinical case of long-term complex treatment of combined complications of LT using minimally invasive endovascular and endoscopic techniques.
Living-related kidney transplantation: first experience at St. Luke’s Clinical Hospital
Authors: Popov S. V. , Orlov I. N. , Sajdulaev D. A. , Sadovnikov S. V. , Gusejnov R. G. , Kisil Yu. V. , Perepelitsa V. V. , Lomonosova Е. V. , Yasheva S. Yu. , Bunenkov N. S.
Published: April 2023

Kidney transplantation (KT) is regarded as the most effective therapeutic approach for people with end-stage renal disease. However, for a number of reasons - constant increase in the incidence of diseases contributing to formation and development of chronic kidney disease, as well as continuing shortage of donor organs - 78-95% of patients in need of a kidney transplant do not receive the necessary treatment, and the waiting list stretches for several years. This paper presents the first outcomes of KT for chronic glomerulonephritis performed at St. Luke’s Clinical Hospital in St. Petersburg, in collaboration with the staff of Shumakov National Medical Research Center of Transplantology and Artificial Organs.
Laparoscopic partial nephrectomy in allograft kidney followed by intrarenal urinary tract reconstruction and ureteral reimplantation (clinical report)
Authors: Trushkin R. N. , Artyukhina L. U. , Isaev T. K. , Medvedev P. E. , Shevcov O. S. , Klementeva T. M.
Published: April 2023

This paper presents a clinical case of laparoscopic nephrectomy for a large (10 cm) renal sinus mass in an allograft kidney, followed by intrarenal urinary tract reconstruction with ureteral reimplantation. The surgery had an acceptable oncological outcome, without loss of kidney function. Regardless of the volume and extent of the tumor process, the use of minimally invasive, nephron-sparing treatment techniques takes a leading position in the treatment of renal cancer in kidney recipients. Intrarenal urinary tract reconstruction allows a kidney to be saved even if the tumor is significantly large and/or inoperable.
Kidney transplantation in a patient with familial mediterranean fever complicated by secondary amyloidosis (clinical report)
Authors: Tayler K. G. , Galeev Sh. R.
Published: April 2023

The paper presents a clinical case of successful kidney transplantation (KTx) in a patient with end-stage chronic kidney disease (ESKD) resulting from familial Mediterranean fever (FMF). Pre-transplant preparation and posttransplant management tactics are presented. The authors conclude that ESKD can be effectively treated by KTx in a patient with FMF against the background of ongoing pathogenetic therapy in autoinflammation.
Personalized dosing protocol for extended-release tacrolimus in kidney transplant recipients in the early postoperative period
Authors: Shabunin A. V. , Drozdov P. A. , Makeev D. A. , Nesterenko I. V. , Zhuravel O. S. , Karapetyan L. R. , Astapovich S. A. , Lidzhieva Е. A.
Published: April 2023

Objective: to develop a personalized algorithm for extended-release tacrolimus in kidney recipients and to analyze its early outcomes in comparison with a retrospective control group.

Materials and methods. The first (I) control group «Standard Protocol» included 228 patients operated on at Botkin City Clinical Hospital from June 2018 to November 2021; tacrolimus was administered postoperatively in a starting standard dosage of 0.2 mg/kg. The second group (II) consisted of 75 patients operated from December 2021 to November 2022, whose postoperative treatment involved a personalized extended-release tacrolimus dosing protocol. Induction immunosuppression was similar in both groups. The target tacrolimus level in the early postoperative period was considered to be 10-12 ng/ml for all patients. The comparison criteria included incidence of Over-immunosuppression (tacrolimus C0 >15 ng/ml), incidence of acute rejection and infectious complications in the first month after surgery, incidence and duration of delayed graft function (DGF), and length of stay at the hospital.

Results. Over-immunosuppression was statistically significantly lower in the personalized protocol group, with 36.7% in group I and 87.5% in group II (p < 0.001). There was also a lower incidence of early infectious complications in group II: 5.4% vs. 13.2%, however, without reaching a level of statistical significance (p = 0.088). DGF incidence in group I and group II were 25.4% (58/228) and 22.7% (17/75), respectively. The length of stay at the hospital in group II was also statistically significantly lower: 13 versus 19 bed days (p = 0.033). In both subgroups, no patient developed acute rejection in the first month after surgery (p = 1).

Conclusion. The personalized dosing protocol that was developed for extended-release tacrolimus in kidney recipients achieves the target levels of the drug recommended for the early postoperative period with low risk of under-immunosuppression and associated acute graft rejection, with a significantly lower incidence of over-immunosuppression.
Assessment of the quality of life of organ reoipients based on the results of the First Russian transplant games
Authors: Shelekhova T. Yu. , Achkasov E. E. , Lazareva I. A. , Krumkacheva Yu. A. , Sungatulina A. A. , Gautier S. V.
Published: April 2023

Objective: to evaluate the role of physical activity (at sports games) in improving the quality of life of organ recipients.

Materials and methods. We examined 42 adult lung, heart, kidney and liver recipients, and patients undergoing renal replacement therapy (mean age 42.6 ± 12.09 years) - participants of the First Russian Transplant Games. The results were analyzed. Quality of life of the recipients was assessed using the nonspecific SF-36 questionnaire.

Results. After solid organ transplantation, the interviewed recipients answered that they try to lead an active lifestyle, to engage in accessible physical activities, and to participate in sports events intended for organ recipients. Assessment of the quality of life according to the SF-36 questionnaire showed that all the participants had high scores in terms of the physical and psychological component, which is associated with regular physical training and sports.

Conclusion. Physical exercise and active participation in sports activities are an important component in the socialization and rehabilitation of organ recipients. These two factors also improve the psychological and physical components of the quality of life of the recipients.
Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation
Authors: Korobka V. L. , Pasechnikov V. D. , Korobka R. V. , Pak E. S. , Shapovalov A. M. , Pasechnikov D. V.
Published: April 2023

Objective: to determine the efficacy of non-selective beta-blockers (NSBBs) in the primary prevention of bleeding esophageal varices and to assess their impact on the survival of patients with ascites enrolled in the liver transplant waiting list (LTWL).

Materials and methods. We carried out a retrospective comparative study of cirrhotic patients with severe ascites and esophageal varices without bleeding before enrollment in the LTWL. Primary prophylaxis of variceal bleeding included the use of NSBBs (n = 97, group 1). These drugs were not used in the other patients (n = 91, group 2).

Results. There were no significant differences between the groups in terms of clinical, laboratory and demographic parameters, MELD scores and Child-Turcotte-Pugh (CTP) classes for cirrhosis. Patient groups included in the study had no significant differences with respect to incidence of medium- and large-sized varices and incidence of severe ascites. Bleeding incidence was significantly lower in the NSBBs group than in the non-NSBBs group (52.6% and 95.6%, respectively, p = 0.0001).

Conclusion. NSBBs constitute an efficacious therapy in primary prophylaxis of esophageal variceal bleeding, thereby saving life and preventing delisting of patients with ascites from the LTWL.
Experience in the use of neutralizing monoclonal antibodies in kidney transplant recipients with COVID-19
Authors: Kim I. G. , Lysenko M. A. , Frolova N. F. , Artyukhina L. Yu. , Buruleva T. A. , Nikitina A. M. , Vinogradov V. E. , Volodina E. V. , Chervinko V. I. , Kryukov E. V. , Zubkin M. L.
Published: April 2023

Therapy with neutralizing monoclonal antibodies (mAbs) is particularly relevant during COVID-19 outbreaks in patients at high risk of severe disease, including kidney transplant recipients (KTRs).

Objective: to evaluate the efficacy and safety of neutralizing mAbs in KTRs with mild to moderate COVID-19.

Materials and methods. The retrospective study included 99 KTRs who received inpatient treatment for COVID-19 between September 1 and December 31, 2021. Patients were 52.0 ± 11.5 years old (M, 47.5%). Bamlanivimab/etesevimab combination drug at a dose of 700/1400 mg was used as mAbs. To evaluate the efficacy of mAbs therapy, two groups of patients were identified. Group 1 consisted of 33 KTRs who received mAbs as one of the therapy components, while group 2 consisted of 66 patients who received no mAbs. Discharge from the hospital or death was considered as the endpoint of follow-up.

Results. In group 1, after the use of mAb, progression of pulmonary process was observed less frequently than in the control group with CT1-2 transformation to CT3-4 (9.1% vs. 30.3%, respectively, p < 0.01). Group 1 KTRs differed significantly from group 2 - lower need for ICU and ventilator care (6.1% vs. 27.3% and 3% vs. 19.8%, respectively). The groups were comparable by sex, age, body mass index, Charlson Comorbidity Index (CCI) and time after kidney transplant (KTx) at the onset of the disease and by rnseline blood biochemistry parameter values at the time of hospitalization. Only C-reactive protein (CRP) and fibrinogen values were higher in the non-mAbs patients who were hospitalized later in the course of the disease (7.7 ± 3.2 days versus 4.6 ± 1.6 days in group 1, p < 0 .001). The frequency of prescription of other therapies did not differ between the compared groups. Use of mAbs significantly reduced mortality from 19.7% in KTRs in group 2 to 3% in group 1 without adverse effect on graft function. Conclusion. The use of mAbs therapy in the early stages of COVID-19 in KTRs is safe, it prevents severe COVID-19, and reduces the incidence of adverse outcomes.
Experience with percutaneous right ventricular support in the early post-left ventricular assist device implantation period (clinical case report and literature reviews)
Authors: Poptsov V. N. , Spirina E. A. , Ryabtsev D. V. , Solodovnikova A. K. , Epremian A. S.
Published: April 2023

Implantable left ventricular assist device (LVAD) is a state-of-the-art treatment for adults and children with end-stage heart failure. The early and late period after LVAD implantation can be severely complicated. Right ventricular failure (RVF) still remains a common complication after LVAD implantation. RVF is the cause of reduced post-implant survival. We suggest that an additional temporary or permanent right ventricular assist device (RVAD) is an effective treatment for LVAD-associated RVF. In this clinical case report, we describe the medical history of a pediatric patient (14 years old) with severe heart failure (PediMACS Level 1) against a background of dilated cardiomyopathy. The patient required peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) prior to urgent LVAD (HM3) implantation. In the early post-LVAD implantation (1 POD) period, the patient presented with hemodynamic and echocardiographic events of acute RVF that was resistant to drug therapy (inotropic/vasopressor support, iNO) and required mechanical circulatory support (MCS) with a preoperatively implanted VA-ECMO. In the LVAD-associated RVF scenario, VA-ECMO as a means of total cardiac bypass is a non-physiological MCS method and, therefore, undesirable. In this clinical situation, our solution was to use a paracorporeal centrifugal blood pump for temporary right heart support. A RVAD was assembled using percutaneous cannulation in two sites and a modification of the pre-existing VA-ECMO circuit. For RVAD, we used an ECMO cannula previously installed through the femoral vein (26 F) and added a reverse venous cannula (22 F) through the right internal jugular vein into the pulmonary trunk. To facilitate the passage of the return cannula into the pulmonary artery, we used a contralateral sheath (6 F, 40 cm) and an Amplatz Super Stiff guidewire under radiological control. The oxygenator was removed from the circuit on day 2 of RVAD. Central hemodynamics (reduction in right atrial pressure (RAP) to 10 mm Hg, increase in pulmonary capillary wedge pressure (PCWP) to 14 mm Hg), as well as right ventricular (RV) and left ventricular (LV) volume characteristics all improved. These observations allowed us to optimize the performance of the implantable LVAD (increase in flow rate to 4.2 l/min or 2.1 l/min/m2). The duration of paracorporeal RVAD after LVAD implantation was 7 days with an average flow rate of 2.3 ± 0.2 l/min. Postoperative treatment in the intensive care unit (ICU) lasted for 15 days. The patient was discharged from the hospital on postoperative day 34.
A study on morphological variations of male Helophorus (Helophorus) aquaticus (L., 1758) (Coleoptera: Helophoridae) in Türkiye
Authors: POLAT Ahmet
Published: April 2023

The geographic structure of Türkiye is well-suited for determining species diversity and interspecific variation as Türkiye has many regions with different altitudes and ecological characteristics. A large number of specimens belonging to the Helophoridae family belonging to the order Coleoptera were collected from different regions of Turkey between 2007-2021, examined and kept as museum material. Among the museum materials evaluated in terms of variation, Helophorus (Helophorus) aquaticus (L., 1758) species were seen to be both more common and more diverse in each region. In this study, male specimens varying in color, size, pronotum, tarsi, and genital structure were selected among the samples collected from different regions and geographic locations within the same locality. A total of 17 different morphological variations were identified and listed by examining the pronotum, elytra, tarsi, and aedeagophore structures. The relationships of these variations with altitude have been evaluated. As a result of this study, it has been determined that variations of the same species can coexist in the same locality, as well as similar variations in localities in different geographical regions. In addition, it was determined that the size of the insects increased as the altitude increased.
Discourse anaphoricity vs. perspective sensitivity in emoji semantics
Authors: Grosz Patrick Georg , Kaiser Elsi , Pierini Francesco
Published: April 2023

This paper aims to provide a foundation for studying the interplay between emoji and linguistic (natural language) expressions; it does so by proposing a formal semantic classification of emoji- text combinations, focusing on two core sets of emoji: face emoji and activity emoji. Based on different data sources (introspective intuitions, naturalistic Twitter examples, and experimental evidence), we argue that activity emoji (case study I) are essentially event descriptions that serve as separate discourse units (similar to free adjuncts) and connect to the accompanying (linguistic) text by virtue of suitable discourse relations. By contrast, face emoji (case study II) are expressive elements that are anchored to an attitude holder and comment on a proposition provided by the accompanying text. We provide further evidence for the distinct behavior of face emoji and activity emoji by looking at their scopal behavior with respect to linguistically- expressed negation. In particular, we probe interactions of emoji and texts that contain clausal negation, and conclude that both face emoji and activity emoji generally do not scope under negation. However, the appearance of such a scope relation arises with activity emoji when the emoji are connected to the accompanying text by virtue of an Explanation discourse relation. With face emoji, scopal interactions seem to appear in cases where the default interpretation would result in a discourse contribution that is pragmatically infelicitous, and also in cases that involve a specialized emoji-repetition construction where a repeated alternation of face emoji with words assumes a scope-marking role.
Polynomial matrix method for synthesizing regulators for objects with a control signal delay
Authors:   Novosibirsk State Technical University, Russian Federation, Voevoda Alexander A. , Filiushov Vladislav Yu. ,   Novosibirsk State Technical University, Russian Federation
Published: April 2023

In this paper, we consider the synthesis of control systems for objects with a control signal delay by a polynomial matrix method, which is used to locate the poles and, if possible, zeros in the required position. The controller is calculated from the output, i.e. only from the measured values in the plant, which is an advantage over other modal direction synthesis methods where a state vector must be used. It is proposed to approximate the delay link with a Padé series with a limited number of terms, thus obtaining transfer functions of the first and second orders. The desired characteristic polynomial of the closed system is chosen so that it contains the denominators of the approximation transfer functions, which will keep their poles in the closed system. The polynomial synthesis method makes it possible to calculate multichannel controllers both for objects with multiple inputs and multiple outputs (multi input - multi output, MIMO) and for objects with one input and several outputs (single input - multi output, SIMO). The latter include a DC motor with independent excitation, where the armature current and rotor speed are outputs, and the control signal applied to the semiconductor converter is the input. In this work, the control signal is formed with a delay exceeding the time of the transient process of the engine, which significantly affects its dynamics. By applying the proposed approach, it was possible to synthesize a rotor speed control system that is resistant to changes in the delay time in a fairly wide range.
Evaluation of the change in photosynthetic active radiation of the LED light source depending on the operating time
Authors:   Tomsk State University of Control Systems and Radioelectronics, Russian Federation, Soldatkin Vasily S. , Tuev Vasily I. ,   Tomsk State University of Control Systems and Radioelectronics, Russian Federation, Khomyakov Artem Yu. ,   Tomsk State University of Control Systems and Radioelectronics, Russian Federation
Published: April 2023

Modern LED light sources make it possible to create the necessary values of photosynthetic irradiance both for growing seedlings and for growing vegetable crops in greenhouse conditions. It is LED light sources that in the near future will replace sodium lamps, which are used in most greenhouses, The area of these greenhouses in the Russian Federation is more than three thousand hectares, with electricity consumption for lighting one hectare of the greenhouse being at least 1 MW per hour. The paper presents the results of experimental studies of the photonic characteristics of LED lamps. Lighting characteristics of LED lamps were measured; light values were recalculated into energy values in accordance with GOST R 58461-2019. Research tests of LED lamps were carried under normal climatic conditions for 10,000 hours, with an intermediate test running time of 5,000 hours. It was found that the arithmetic mean value of photosynthetic irradiance decreased by 1.9 times. In the process of operation, a spectral component in the blue region of the optical spectrum grows from 0.35 to 0.6 relative units, while the spectral component in the yellow-red region of the optical spectrum decreases with time of operation. The decrease in photosynthetic irradiance is caused with the degradation of the phosphor composition over time. The results of these studies can be used by developers of LED light sources in order to improve the preservation of photonic characteristics over time, and in particular, to improve the phosphor composition that provides photosynthetic irradiation of the light source over time.
Biovalley analysis as a LID control to delay surface runoff in the city of Recife/PE
Authors: Santana Kássia Carneiro da Silva , Soares Willames de Albuquerque
Published: April 2023

Urban growth brought with it the formation of large impermeable areas in cities, causing a reduction in the infiltration of rainwater into the soil and an increase in the volume of surface runoff, causing setbacks on days of extreme precipitation events. In this context, the present research aimed to analyze the use of a biotaver as a Low Impact Development (LID) for delaying surface runoff in areas prone to flooding in the city of Recife/PE. As a methodology, the QGIS model was used to extract data from raster images, and the Storm Water Management Model (SWMM) for scenario simulation. Three scenarios were simulated with rainfall of 20.00mm, 39.00mm and 60.00mm. The results showed that the implementation of the bioditches provided a reduction in the total flow of the study area by 0.50% and in the maximum flow of the SB1 sub-basin for scenarios 2 and 3 by 77.96% and 41.23% respectively. In addition, there was a reduction in surface runoff of 11.15% on average and an increase in green area of 4.00%. The bioretention system showed infiltration ranging from 29.83mm to 89.35mm between the three scenarios. Thus, through the SWMM model, it was possible to analyze that the implantation of bioditches as a control for delaying surface runoff and increasing infiltration into the soil is valid, and the literature recommended that various types of sustainable devices be implemented and integrated into the existing drainage network and urban space so that more expressive results are possible.
Corpo-Cidade: Território da experiência
Authors: França Rebeca Falcão dos Santos Melo , Carvalho Gabriel Lincoln Lopes
Published: April 2023

Corpo-cidade: Território da experiência, é uma pesquisa que tem como objetivo geral levantar reflexões acerca do corpo e da cidade, e de suas relações, propondo pensar a experiência do indivíduo com a cidade mediada através do nosso corpo, o corpo ao qual pertencemos. Tendo como objetivos específicos:  Apresentar a cidade enquanto território de experiências e o corpo enquanto meio de experienciar o espaço. Utilizando como embasamento teórico fundamentado em pesquisas bibliográficas, procura-se aqui discutir esta relação a partir da ideia de corpo trazida por Merleau-Ponty ([1945] 2018), que explana este indivíduo capaz de reconhecer sua própria existência enquanto sujeito vivo e perceptivo, associando-o ao contexto da cidade trazidas durante os anais do Seminários de História da cidade e do urbanismo (SHCU), explicando a cidade enquanto espaço de vivências e interações, trabalhando-a para além de sua constituição material, pensando-a enquanto local de reduto da individualidade. É por meio desta discussão que buscamos elucidar a concepção de corpo e suas influências adivindas da cidade, mediante seu caráter perceptivo, apresentando a cidade enquanto fenômeno que se evidencia pela percepção e o corpo enquanto meio de vivenciar o espaço e compreender a expressão do viver urbano.

 

PALAVRAS-CHAVE: Corpo. Cidade. Experiência
Derin öğrenme kullanılarak mobil cihazlar için gerçek zamanlı yangın ve duman tespiti
Authors: ŞAFAK Emre , BARIŞÇI Necaattin
Published: April 2023

Yangın; ekolojik, sosyal ve ekonomik zararlara neden olan doğal afettir. Küresel ısınma ve patlayıcı/yanıcı kimyasalların kullanımının yaygınlaşması ile birlikte yangınlar insanlık için en önemli sorunlardan biri haline gelmiştir. Yangınların erken tespiti tahribatı en aza indirmek için kritik öneme sahiptir. Binalarda yangınların erken tespit edilmesini sağlayabilmek için ısı ve duman dedektörleri geliştirilmiştir. Ancak bu dedektörlerin kullanımı kapalı alanlar ile kısıtlıdır. Geniş alanlarda bu detektörlerin kullanılması mümkün değildir. Ayrıca bu dedektörler kurulum ve bakım açısından oldukça maliyetlidir. Bu nedenlerden dolayı görüntülerden yangın tespiti üzerine çalışmalar yapılmaya başlanmıştır. Görüntülerden yangın tespiti için yapılan son çalışmalarda genellikle derin öğrenme algoritmaları kullanılmaktadır. Bu çalışmalar kameralar üzerinden alınan görüntülerin güçlü sunucular üzerinde çalışan modeller ile analizine odaklanmaktadır. Mobil cihazlar ve nesnelerin internetindeki gelişmeler ile artık uç cihazlar üzerinde görüntüler analiz edilebilir. Yapılan çalışmada görüntülerin bir sunucuya aktarılmadan mobil cihaz üzerinde analiz edilmesini sağlayacak düşük işlem gücü gerektiren yangın ve duman tespit modeli geliştirilmiştir. MobileNet evrişimsel sinir ağı revize edilerek son 3 katman kaldırılmış ve yerine düzleştirme katmanı ile iki düğümden oluşan yoğun katman eklenmiştir. Yangın ve duman tespiti modeli için revize edilmiş MobileNet, orijinal MobileNet, MobileNetV2, EfficientNetB0 ve ShuffleNet evrişimsel sinir ağları kullanılarak geliştirilen modeller arasından en yüksek doğruluk oranına sahip yöntem belirlenmiştir. Modellerin başarı oranını artırabilmek ImageNet üzerinde ön eğitilmiş model ağırlıkları transfer öğrenme tekniği ile tekrar kullanılmıştır. Modelleri eğitmek ve test etmek için 43,355 görüntüden oluşan veri seti kullanılmıştır. Veri setinin %80’i eğitim %20’si test işlemi için kullanılmıştır. Yapılan test sonuçlarına göre revize edilmiş MobileNet ağı %98,37 ile en yüksek doğruluk oranına ulaşılmıştır.
Beyşehir Gölü Milli Parkı çevresel değerlemesinin seyahat maliyeti ve koşullu değerleme yöntemleri ile belirlenmesi
Authors: KARAKAYACI Zuhal , KARAKAYACİ Ozer , POLAT Ahmet
Published: April 2023

Dünya nüfusunun giderek artmasıyla birlikte plansız büyüme, kentleşme, sanayileşme ve buna bağlı olarak iklim değişikliği gibi gelişmeler doğal kaynakların korunmasını zorunlu hale getirmiştir. Bu kapsamda korumaya alınan doğal kaynakların başında Milli Parklar gelmektedir. Milli park kavramının ortaya çıkmasına neden olan temel etken doğal, tarihi ve kültürel değerlerin korunması ihtiyacı olmuştur. Bu amaçla Türkiye’nin en büyük ikinci milli parkı olan Beyşehir Gölü Milli Parkı’nın değerlemesi yapılmıştır. Değerlemede Koşullu Değerleme Yöntemi ve Seyahat Maliyeti Yöntemi kullanılmıştır. Veri toplama aşamasında Oransal Örnekleme Yöntemi kullanılarak örnek sayısı 383 adet belirlenmiş olup, anketler 2019 yaz döneminde milli park sınırları içerisinde ziyaretçilerle yapılmıştır. Beyşehir Gölü Milli Parkı’na Koşullu Değerleme Yöntemine göre 186.838.123 TL, Seyahat Maliyeti Yöntemine göre 453.612.000 TL hesaplanmış olup, toplam ekonomik değeri 640.450.123 TL olarak belirlenmiştir. Ziyaretçi başına tüketici rantı, yani bir yıl içerisinde milli park ziyareti için ödemeye razı olduğu ücret ise 2.202TL olarak hesaplanmıştır. Elde edilen tüm bulgular ışığında ülkenin milli gelirinde payı olan Türkiye’nin ikinci büyük milli parkının ekonomik değeri ve mevcut potansiyeli ortaya konulmuştur. Ekonomik değeri kalkınma politikalarında değerlendirilmeli, mevcut potansiyeli ise çevre koruma politikaları çerçevesinde korunarak insanların sosyal faydasına sunulmalıdır.
İNVAZİV MELANOMLARDA CD271 VE BRAF EKSPRESYONUNUN KLİNİKOPATOLOJİK PARAMETRELERLE VE PROGNOZ İLE İLİŞKİSİNİN İMMÜNOHİSTOKİMYASAL YÖNTEMLE ARAŞTIRILMASI
Authors: KARAHAN Nermin , UĞUZ Afife
Published: April 2023

Amaç

Amaç: İnvaziv melanomun (İM) en önemli prognostik

faktörleri patolojik evreleme ve metastaz varlığı olarak

bilinmektedir. Patolojik evrelemede tümör boyutu, invazyon

derinliği, ülserasyon, mitotik indeks önem arz

etmektedir. Çalışmamızda BRAF V600E ve CD271’in

immünohistokimyasal (İHK) ekspresyonları ile klinikopatolojik

parametreler ve prognoz ile ilişkisinin incelenmesi

amaçlanmıştır.

Gereç ve Yöntem

Çalışmamızda Süleyman Demirel Üniversitesi Patoloji

Anabilim Dalı’nda Aralık 2010 - Mayıs 2017 tarihleri

arasında tanı almış 47 İM olgusu incelendi. Bu olgulara

BRAF V600E ve CD271 belirleyicileri uygulandı. Bu

belirteçlerin primer ve metastatik İM’lerda ve sağkalım

ile ilişkisi immünohistokimyasal yöntemle araştırıldı.

Ayrıca primer ve metastatik İM’ların ülser, lenfositik infiltrasyon,

pigmentasyon, mitoz, Breslow kalınlığı, metastaz

yapıp yapmaması, yaş, cinsiyet ve sağkalım ile

ilişkisi araştırıldı.

Bulgular

Primer İM’ler ve metastatik İM’ler karşılaştırıldığında

ülserasyon, mitotik indeks açısından, aralarındaki fark

istatistiksel olarak anlamlı bulunurken, Breslow tümör

kalınlığı, lenfositik infiltrasyon, pigmentasyon, CD271

ve BRAF V600E ekspresyonu açısından aralarındaki

fark istatistiksel olarak anlamlı bulunmadı. Sağkalım

ile ilişkilerine bakıldığında Breslow tümör kalınlığı, ülserasyon,

BRAF V600E ekspresyonu şiddeti, BRAF

V600E ekspresyonu olmayanlar ile olanlar arasındaki

ve BRAF V600E ekspresyon şiddeti 3+ olanlar ile

diğerleri arasındaki fark istatistiksel olarak anlamlı

bulundu. Cinsiyet, pigmentasyon, BRAF V600E ekspresyon

yüzdesi, CD271 ekspresyon şiddeti, CD271

ekspresyon yüzdesi ile sağkalım arasında istatistiksel

olarak anlamlı fark bulunmadı. Çalışmamızda Primer

İM’si olan bireylerin yaşları 35-93 arasında değişmekte

olup ortalama 64,12 ± 20,35, metastatik İM grubundaki

bireylerin yaşları 35-89 arasında değişmekte olup ortalama

69 ± 13,42 idi. Yaş yönünden iki grup arasındaki

fark anlamlı bulunmadı.

Sonuç

Çalışmamız sonucunda elde ettiğimiz verilerde BRAF

V600E ekspresyonu prognoz ile ilişkili olduğu gözükmektedir.

BRAF V600E ekspresyonu olmayanlarda

yüksek sağkalım oranları varken ekspresyon şiddeti

yüksek olanlarda sağkalımın azaldığı bulundu. Çalışmamızda

CD271 ekspresyon şiddeti ve yüzdesi açısından

primer ve metastatik İM gruplarında ve sağkalım

arasında istatistiksel olarak anlamlı fark bulmadık.
HTTM : Transposon mutagenesis v1
Authors: Champie Antoine
Published: April 2023

Part of the HTTM protocol dedicated to the transposon mutagenesis of targets cells.