bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymorphisms of Candidate Genes Associated with Growth and Carcass Traits in Canadian Duroc Pigs
Authors: Tinh Nguyen Huu , Hop Nguyen Van , Anh Nguyen Thi Lan , Bui Anh Phu Nam
Published: September 2021

Background: Selection based on traits such as average daily gain (ADG) and carcass quality in commercial pig populations have drawn attention of swine breeders due to the correlation with growth and consumer preference for carcass composition, respectively. The association between melanocortin 4 receptor (MC4R) gene, which encodes the G-protein-coupled receptor and ADG and carcass quality, have been well documented. The study was conducted to determine the effects of MC4R/TaqI and PIT-1/RsaI polymorphisms on growth and carcass quality traits in total of 576 Duroc pigs at national breeding farms of Vietnam. Methods: After the performance test, the desired traits including ADG, IF and LD were measured. ADG (g/day) was calculated as the live weight divided by the number of days from birth to 100 kg, BF and LD can be captured at position P2 (6-8 cm away from body midline at the last rib level) with Ultrasound machine Aloska SSD 500V. Genomic DNA were collected and genotyped to observe the polymorphism of MC4R and PIT-1. Result: Three genotypes AA, AG andGG of MC4R gene and AA, AB and BB of PIT-1 gene were found in the studied pig population. The observed frequencies of AA, AG and GG were 0.09, 0.41 and 0.50 (MC4R gene) and for AA, AB and BB were 0.37, 0.47 and 0.16, respectively. The G allele (MC4R) and B allele (PIT-1) have more positive effects on traits of ADG, BF and LD. Specifically, in MC4R gene, the individuals carrying GG genotype had higher ADG by 50 gram and lower BF by 1.4 mm than AA genotype. In PIT-1 gene, pigs carrying BB genotype had higher ADG and LD than AA genotype by 37 gram and by 1.9 mm, respectively. Therefore, the increased selection of G allele, GG genotype (MC4R) and of B allele, BB genotype (PIT-1) should be considered to contribute to the improvement of ADG, BF and LD traits in Duroc population in current study.
Cementation exponent estimate in carbonate reservoirs: A new method
Authors: Shirazy Adel , Khayer Keyvan , Shirazi Aref , Ansari Abdolhamid , Hezarkhani Ardeshir
Published: September 2021

There are two approaches for measuring hydrocarbon saturation: well log interpretation and usually developed formulas. Archie’s equation is one of the most fundamental equations used for water saturation calculation. Archie’s equation includes three factors: cementation factor, tortuosity and saturation exponent. Archie determines these factors based on lab results in sandstone and provides fixed value for them. Carbonate reservoirs have a variety of textures, shapes and distribution of pores; therefore, the mentioned factors, especially cementation are not considered constant. In this study, the relationship between cementation factor and density log was examined because cementation factor is defined as a parameter that has a close relationship with density. By calculating the matrix density and accordance factor between the matrix density and cementation factor from core’s analysis, a log will be generated that can estimate the variation of cementation factor around the borehole. This method is useable for calculating the cementation factor in carbonate rocks.
 
Keywords: Cementation factor, carbonate reservoir, density, new method, exponents.
Lipom eksizyonu sırasında stres küpü kullanımının ağrı ve anksiyete üzerine etkisi
Authors: BOZDOĞAN YEŞİLOT Saliha , ÇİFTÇİ Hatice , YENER Mehmet Kemal
Published: September 2021

Amaç: Lokal anestezi altında gerçekleştirilen cerrahi işlemlerde bireylerde oluşan ağrı ve anksiyete yönetilmesi gereken önemli sağlık bakım sorunlarındandır. Bu araştırma lipom eksizyonu sırasında stres küpü kullanılarak dikkati başka yöne çekmenin ağrı ve anksiyete üzerine etkisinin değerlendirilmesi amacı ile gerçekleştirilmiştir.
Gereç ve Yöntem: Araştırma 1 Ekim 2019-1 Mart 2020 tarihleri arasında gerçekleştirilmiştir. Lokal anestezi altında lipom eksizyonu yapılacak, 18 yaşından büyük, yeterli görme, işitme ve konuşma işlevlerine sahip, Türkçe bilen, çalışmaya katılmayı kabul eden bireyler çalışmaya dahil edilmiştir. Verilerin toplanmasında Kişisel Bilgi Formu, Durumluk Kaygı Envanteri ve Sayısal Derecelendirme Ölçeği kullanılmıştır. Çalışma müdahale grubunda 46 kontrol grubunda 46 olmak üzere toplam 92 bireyle gerçekleştirilmiştir. Müdahale grubu lipom eksizyonu sırasında stres küpü kullanmış, kontrol grubu hastanedeki rutin tedavisini almıştır.
Bulgular: Katılımcıların %68,5’i erkek, %31,5’i kadındır. Araştırmaya katılan bireylerin yaş ortalaması müdahale (41,67±11,48) ve kontrol (44,59±13,83) grubunda benzerdir (p=0,275). Eksizyon işlemi sırasındaki ağrı şiddeti ortalamaları bakımından müdahale (2,67±1,69) ve kontrol (4,46±2,82) grubu arasında istatistiksel anlamlı bir fark vardır (p<0,001). Eksizyon işlemi öncesi müdahale (38,63±5,24) ve kontrol (40,39±6,04) grubunun anksiyete puan ortalamaları benzerdir (p=0,139). Girişim sonrası gruplar arasında (Müdahale grubu=42,63±5,26; Kontrol grubu= 41,76±5,50) anksiyete puan ortalamaları arasında anlamlı fark yoktur (p=0,440).
Sonuç: Bu araştırma sonucunda yapılan girişimin lipom eksizyonu sırasındaki ağrıyı azalttığı ancak anksiyete üzerine etkisinin olmadığı belirlenmiştir. Bu girişimin lokal anestezi altında gerçekleştirilen lipom eksiyonlarında işlem sırasındaki ağrının azaltılmasında rutin olarak kullanılması önerilmiştir
Pulmoner emboli vakalarında AngioJet yardımı ile yapılan reolitik farmako-mekanik trombektomi uygulamalarında anestezi deneyimimiz
Authors: İNANGİL Gökhan
Published: September 2021

Amaç: Bu çalışmada pulmoner emboli endikasyonu ile reolitik trombektomi uygulanan olgulardaki erken dönem anestezi deneyimlerimizi sunmayı amaçladık.

Gereç ve Yöntem: Eylül 2016-Mayıs 2018 tarihleri arasında pulmoner emboli tanısı ile hibrit ameliyathanede AngioJet reolitik trombektomi uygulanan 25 hasta retrospektif olarak incelendi. Hastaların demografik verileri, ameliyat sırasında ve sonrasında gelişen komplikasyonlar değerlendirildi.

Bulgular: AngioJet yardımı ile reolitik trombektomi uygulanan toplam 25 hastada (11 erkek, 14 kadın; ort. yaş 61,4 ± 14,9 yıl; dağılım 22-83 yıl) lokal anestezi ile birlikte sedasyon uygulamalasının tercih edildiği görüldü. İşlem esnasında bradikardi ve öksürük sık olarak karşımıza çıkan yan etkiler olarak belirlendi. İki hastamızda öksürük sonrası hemoptizi gelişti. Hasta pozisyonuna veya anesteziye bağlı komplikasyon gelişmedi.

Sonuç: Gelişen yeni cerrahi ve perkütan girişimsel tekniklere paralel olarak anestezi uzmanları da uygun anestezi planı ve yönetim stratejisi oluşturmalıdır. Perkütan temelli girişimsel yöntemlerin, özellikle hibrit ameliyathanelerde ve kardiyak anestezi prensipleri uygulanarak yakın monitörizasyon ile izlenmesi gerektirmektedir. Bununla beraber oluşabilecek komplikasyonlar ve acil cerrahi embolektomi ihtiyacı oluşabileceği akılda tutulmalıdır.
Klinik ön tanı ve elektrofizyolojik tanılar arasındaki tutarsızlık: 3. basamak elektronörofizyoloji laboratuvarı retrospektif verileri
Authors: ALTUNIŞIK Erman , ARIK Ali
Published: September 2021

Amaç: Bu çalışmanın amacı elektrofizyoloji laboratuvarına yönlendirilen hastaların ön tanısı ile elektronöromiyografi incelemesi sonrası ortaya konulan elektrofizyolojik tanı uyumunun araştırılmasıdır.

Gereç ve Yöntem: Retrospektif dizayn edilen bu çalışmaya elektrofizyoloji laboratuvarına 2019 yılı içinde başvuran ve elektronöromiyografi incelemesi yapılan 1314 hasta dahil edildi. Hastalara ait yaş, cinsiyet gibi sosyodemografik özellikler, ön tanı, ön tanının yapıldığı klinik, elektrofizyolojik inceleme sonucunda elde edilen tanı, ön tanı ile elektrofizyolojik inceleme sonrasında elde edilen tanının tutarlılığı gibi veriler medikal kayıtlardan elde edildi.

Bulgular: Çalışmaya 784’ü (%59,7) kadın, 530’u (%40,3) erkek toplam 1314 hasta dahil edildi. Elektronöromiyografi sonuçlarına göre hastaların %61,4’inin (n=807) incelemesi normal olarak değerlendirildi. Hastaların %34,9’inde (n=458) ön tanılarla elektronöromiyografi tanıları uyumlu bulunurken, %3,7’ne (n=49) ise ön tanılardan farklı patolojik elektrofizyolojik tanılar konuldu. Ön tanılarla elektronöromiyografi tanıları arasında uyum oranlarına bakıldığında poliomyelit, periferik sinir hasarı ve kranial nöropati ön tanılarının tanısı ile uyum oranları diğer ön tanılardan anlamlı derecede yüksekti. Erkek cinsiyetin tanı uyumu kadın cinsiyete oranla anlamlı derecede yüksek saptandı. Yaş arttıkça tanı uyumunun yaşla korele olarak arttığı görüldü.

Sonuç: Elektronöromiyografi sadece tanı koymada değil ayırıcı tanı yapma ve ön tanıyı dışlama konusunda da kullanılmaktadır. Tetkik öncesinde ayrıntılı nörolojik muayene yapılması ve uygulayıcı hekimin bilgilendirilmesi gereksiz bazı işlemleri azaltabilir
Relationship of multiple myeloma with ABO blood groups
Authors: YANARDAĞ AÇIK Didar , BANKİR Mehmet , AVCİ Begüm Seyda
Published: September 2021

Aim: Multiple myeloma is a heterogeneous, incurable haematological cancer that occurs as a result of the clonal proliferation of plasma cells. The impact of blood groups on human diseases and/or their role in the prognosis of the disease has attracted the attention of scientists since the discovery of blood groups. We investigated the blood group distribution of multiple myeloma patients and whether their blood groups are related to immunoglobulin type.

Materials and Methods: 75 multiple myeloma patients and 73128 control group were included in the study, which was planned retrospectively. The statistical evaluation was performed by using Statistical Package for Social Sciences (SPSS) software for Windows 20 (IBM SPSS Inc., Chicago, IL). The normal distribution of the data was evaluated with the Kolmogorov-Smirnov test.

Results: In multiple myeloma patients, the rate of A and B blood groups was low, and the rate of O and AB blood groups was high. Heavy chain IgA ratio was higher in B blood group compared to other blood groups. On the other hand, IgG ratio was found higher in O blood group compared to other blood groups.

Conclusion: A relationship has been found between immunoglobulin type and blood types in multiple myeloma. More comprehensive studies are needed on this subject.
Tecnologia educacional para a prevenção de doenças em crianças pré-escolares e escolares
Authors: Teixeira Barbosa Emanuel Adenilton , Mota Andrade Vanderlene , Almeida de Oliveira Talita , Amaral Viana Maria Corina , Camelo Chaves Edna Maria , Da Silva Santos Aliniana
Published: September 2021

Objetivo: Relatar a experiência acerca da criação e aplicação de uma tecnologia educacional de enfermagem voltada para a lavagem das mãos como forma de prevenção de doenças entre pré-escolares e escolares. Método: Estudo descritivo do tipo relato de experiência, realizado por acadêmicos do curso de Enfermagem, durante o estágio supervisionado. Resultados: A experiência oportunizou o aprendizado sobre a elaboração de uma tecnologia educacional voltada para o público infantil utilizando ferramentas atrativas para a idade. A aplicação de uma atividade educativa planejada foi essencial ao processo de formação como enfermeiros, sendo essa experiência positiva, para auxiliar no planejamento de futuras intervenções educacionais, utilizando ferramentas educativas de acordo com o público-alvo. Conclusão: Essa experiência foi positiva, para auxiliar no planejamento de futuras intervenções educacionais, utilizando ferramentas educativas de acordo com o público-alvo.
Possibilidades para promover a saúde de imigrantes haitianos: percepções de estudantes de enfermagem
Authors: De Souza Jeane Barros , Tomasi Yaná Tamara , Vixamar Jonathan , Schleicher Maira Lidia , Walker Fernanda , Heidemann Ivonete Teresinha Schulter Buss
Published: September 2021

Objetivos: Conhecer as percepções dos estudantes de enfermagem sobre as possibilidades de promover a saúde de imigrantes haitianos no Brasil. Método: Pesquisa qualitativa, tipo ação participante, fundamentada no Itinerário de Pesquisa de Paulo Freire, que possui três fases interligadas: Investigação Temática; Codificação e Descodificação; Desvelamento Crítico. Realizou-se um Círculo de Cultura, em 2019, com a participação de 12 estudantes de enfermagem, de uma universidade pública do Sul do Brasil. Resultados: No Círculo de Cultura, discutiram-se as temáticas: saúde física e mental; ser universitário e trabalhador; adaptação no Brasil. Conclusão: Há invisibilidade de discussões sobre a saúde dos imigrantes na formação do enfermeiro, tendo diversas possibilidades de promover a saúde desse público: criação de espaços de lazer e interação na universidade; políticas de permanência; valorização do trabalho dos haitianos; organização de casa de apoio; cartilha informativa na língua nativa, com vista a ampliar a qualidade de vida dos imigrantes no Brasil
Effects of different calcium oxide dipping concentrations in aroma profiles of pink lady apple cultivar during cold-storage
Authors: EKİNCİ Neslihan , GÜNDOĞDU Mehmet Ali , ŞEKER Murat
Published: September 2021

Objective: The aim of this research was to assess the profile of volatile compounds changes during the cold storage in ‘Pink Lady’ apples.
Material and Methods: Six-year-old Cripps Pink (Pink Lady) fruits of apple trees grafted onto M9 rootstock were used as a plant material for this study. The trees were in a commercial orchard in Çanakkale-Turkey. Fruits were carefully picked up by hand at the commercial harvesting time. The fruits were dipped into calcium oxide solutions (concentrations of 2 and 4%) during three minutes. Control fruits were exposed to distilled water. Fruits were stored at 0° C and 90% relative humidity for 6 months. The aroma profiles of apples determined by GC/MS (Gas Chromatography/Mass Spectrometry) analysis followed by liquid-liquid extraction. Stored fruits were analyzed for their volatile contents at the 2nd, 4th and 6th months.
Results: Fresh fruits at harvest period contained 15 volatile compounds in total. However, higher levels of aroma volatile compounds were detected in 6 months of cold storage. According to the chromatography results, control fruits had 24 volatile compounds, 2% CaO treated fruits had 25 volatiles and 4% CaO treated fruits had 27 volatile compounds at the end of the 6 months of cold storage. Apples at the initial stage produced an abundance of hexyl acetate (4.56%), butyl acetate (3.83%), and hexyl hexanoate (1.68%), which confer typical apple aroma characteristics. Mostly, ester production exhibited a fairly broad peak, declining as fruit aged. Isobutyric acid, allyl ester (initial 0.55%) was lower at the beginning of the storage compare to the end of storage (control fruits 0.06%, 2%CaO 0.13%, 4% CaO 0.20%).
Conclusion: CaO applications especially 4% concentration had deformation effect on epidermal layer cells on fruit surface. As a result, CaO applications had a significant effect on aroma enhancement in Pink Lady apples during cold storage.
As ruínas arqueológicas do México
Authors: De la Torre Renée , Gutiérrez Zúñiga Cristina
Published: September 2021

Este artigo aborda as origens das atuais e massivas práticas rituais e espirituais que ocorrem em dois dos principais sítios arqueológicos do México, Teotihuacán e Chichen-Itzá, escolhidos como estudos de caso que apresentam aspectos comuns e contrastes no que diz respeito à gestão governamental do patrimônio e às tensões geradas entre os diferentes atores, lógicas e abordagens envolvidas. Teotihuacán se trata de um lugar em que ocorreram eventos-chave do nacionalismo cultural, do movimento cultural da mexicanidade e do sentido esotérico, enquanto Chichen-Itzá se localiza na região maia onde as redes globais de espiritualidades ligadas à Nova Era convergiram com os circuitos de neomexicanidade. Por meio de entrevistas e acompanhamento bibliográfico de líderes espirituais que inovaram ritualmente com seus projetos culturais de orientação esotérica, newager, de mexicanidade (indianista), neomexicanidade e neopaganista, reconstrói-se os diferentes projetos que definiram zonas arqueológicas como lugares sagrados para a rede global de espiritualidade alternativa. Atenção especial é dada à forma como as zonas arqueológicas se tonaram arenas de disputa a partir do sentido de patrimônio, em que convergem diferentes agentes (INAH, UNESCO, agências de turismo, líderes espirituais da mexicanidade, indígenas, guardiões da tradição local e gurus da Nova Era) que buscam redefinir e gerenciar sua memória, identidade, significado e uso.
Por que todos esses "Neos"? Por que agora?
Authors: Gauthier François
Published: September 2021

Este artigo começa com uma crítica às atuais abordagens dominantes que compartilham os pressupostos implícitos do que chamo de “paradigma da secularização”, mostrando como e por que essas abordagens são inadequadas para compreender a importância e constituição da Neo-Nebulosa (Nova Era, Neopaganismo, Neoindianismo, Neoxamanismo e fenômenos relacionados). O artigo então se propõe a esboçar os contornos dos modelos do Estado-nação e do Mercado-global, destacando as características específicas da religião em ambos os regimes. Em seguida, é realizada uma discussão que mostra como as características das religiosidades Neo-Nebulosas podem ser relacionadas às condições sociais criadas pela revolução neoliberal e consumista. A análise conclui argumentando que a religião Neo-Nebulosa atua na produção de um self cosmopolita que pode navegar nos fluxos em constante movimento do capitalismo global contemporâneo - em composições mais ou menos contraculturais, para um público predominantemente urbano, educado e de classe média -, enquanto “engrandece” e conecta o Self, a natureza e o cosmos. O foco específico do artigo é a América Latina, em sua relação ao “Ocidente” e às tendências globais. Também são incluídas algumas notas sobre a questão do “reencantamento” ou (re)apropriação de sítios arqueológicos pela Neo-Nebulosa.
A peregrinação de turistas espirituais franceses às fontes do neoxamanismo mexicano:
Authors: Lombardi Denise
Published: September 2021

Neste artigo, analisaremos uma jornada dedicada à descoberta das “fontes do conhecimento indígena” empreendida em março de 2009 por franceses em um país até então desconhecido por eles: o México. Mais especificamente, examinaremos suas formas de participação nessa jornada organizada por um xamã de origem otomi, chamado por seus seguidores pelo termo vernáculo Bädi, ou seja, “o xamã” na língua otomi. O objetivo dessa viagem é permitir que eles descubram as origens do xamanismo, que o organizador vincula à história dos povos indígenas. Além de visitar sítios arqueológicos pré-hispânicos, a viagem também inclui uma visita ao país Otomi, que é apresentado como um dos centros do xamanismo mexicano.
efectos culturales de la creatividad ritual del neopaganismo
Authors: De la Torre Renée , Gutiérrez Zúñiga Cristina , Dansac Yael
Published: September 2021

En los últimos cincuenta años han surgido diferentes movimientos espirituales que no corresponden al modelo de iglesia y que debido a su carácter fluido y dinámico han propiciado un avance de redes globales y han contribuido a hacer de las fronteras especializadas campos cada vez más porosos y permeables. Ha surgido así un abanico de prácticas y creencias relacionadas con el neopaganismo, el New Age, los neoindianismos y las neoetnicidades. Estas tres modalidades espirituales se inscriben en ideologías diferenciables que entrecruzan lo espiritual, lo terapéutico, lo político y lo identitario, y coinciden en una búsqueda de saberes y técnicas corporales que recuperan el sentido espiritual de la vida como salida al materialismo de la cultura de consumo vigente en estos tiempos. No obstante, también tienen distintos énfasis que permiten distinguirlos, aunque constantemente se entrecruzan y suelen compartir elementos comunes e incluso pueden ser practicadas en una misma ceremonia.
CHOOSING A QUALITY CRITERION FOR EVALUATING THE FORECAST OF NONLINEAR NON-STATIONARY PROCESSES
Authors: Belas Andrii O. , Bidyuk Petro I.
Published: September 2021

Background. The problem of forecasting nonlinear nonstationary processes presented in the form of time series is very relevant, since such series can describe dynamics of the processes in both technical and economic systems. To establish the best model, various metrics are used to assess the quality of forecasts, such as R^2, RMSE, MAE, MAPE. However, in many tasks, when optimizing the model according to the selected criterion, the model becomes worse in relation to another criterion. Therefore it is important to understand which metric must be used to optimize and assess the quality of the forecast in the given task.
Objective. The aim of the paper is to develop a criteria base for assessing forecasts of nonlinear nonstationary processes, as well as an approach to choosing a metric in accordance to the specificity of the set forecasting problem.
Methods. The paper presents a comparative analysis of the basic metrics for the regression problem, their theoretical and practical meaning, advantages and disadvantages in various cases. New approaches are proposed based on the results of the analysis.
Results. Based on the analysis of the selected data, it is shown that by optimizing the model according to the selected criterion, the model becomes worse in relation to another criterion. A criterion basis for assessing forecasts of nonlinear nonstationary processes has been formed, as well as an approach to the selection of a quality criterion in accordance with the specifics of the set forecasting problem. To minimize an absolute error, the RMSE (MSE, R^2) and MAE metrics are analysed and recommended, depending on the need to work with outliers. The RMSLE metric is proposed for solving the problems of minimizing the relative metric, for solving the shown problems of the MAPE metric for this class of problems.
 Conclusions. The paper shows the importance of choosing a metric that must be used to optimize and assess the quality of the forecasts in the given task. The obtained criterion base and approach can be used in further research to solve practical prob- lems in modelling and forecasting nonlinear nonstationary processes and to develop new methods or general method for solving such problems.
METHOD OF SYSTEM ENGINEERING OF NEURAL MACHINE TRANSLATION SYSTEMS
Authors: Maslianko Pavlo P. , Sielskyi Yevhenii P.
Published: September 2021

Background. There are not many machine translation companies on the market whose products are in demand. These are, for example, free and commercial products such as “GoogleTranslate”, “DeepLTranslator”, “ModernMT”, “Apertium”, “Trident”, to name a few. To implement a more efficient and productive process for developing high-quality neural machine translation systems (NMTS), appropriate scientifically based methods of NMTS engineering are needed in order to get a high-quality and competitive product as quickly as possible.
Objective. The purpose of this article is to apply the Eriksson-Penker business profile to the development and formalization of a method for system engineering of NMTS.
Methods. The idea behind the neural machine translation system engineering method is to apply the Eriksson-Penker system engineering methodology and business profile to formalize an ordered way to develop NMT systems.
Results. The method of developing NMT systems based on the use of system engineering techniques consists of three main stages. At the first stage, the structure of the NMT system is modelled in the form of an Eriksson-Penker business profile. At the second stage, a set of processes is determined that is specific to the class of Data Science systems, and the international CRISP-DM standard. At the third stage, verification and validation of the developed NMTS is carried out.
Conclusions. The article proposes a method of system engineering of NMTS based on the modified Erickson-Penker business profile representation of the system at the meta-level, as well as international process standards of Data Science and Data Mining. The effectiveness of using this method was studied on the example of developing a bidirectional English-Ukrainian NMTS EUMT (English-Ukrainian Machine Translator) and it was found that the EUMT system is at least as good as the quality of English-Ukrainian translation of the popular Google Translate translator. The full version code of the EUMT system is published on the GitHub platform and is available at: https://github.com/EugeneSel/EUMT.
GENERATIVE DESIGN OF A FRAME TYPE CONSTRUCTION
Authors: Mastenko Ihor V. , Stelmakh Nataliia V.
Published: September 2021

Background. In recent years, there has been a rapid development of the domestic military industry. Reducing the mass and increasing the specific strength of military products used in the field – the most pressing challenges facing engineers and scientists today. The rapid development of adaptive production has significantly expanded the possibilities of methods of topological optimization in the design of new products or improvement of existing design and technological solutions in order to reduce weight.
Objective. The purpose of the paper is to improve the efficiency of designing the technology of manufacturing a frame type construction based on the method of topological optimization, which will reduce the weight of the product, while maintaining all the specified functional parameters.
Methods. The paper presents an analysis of topological optimization methods and offers the interaction of modern ADS, namely CAD, CAM, CAE modules at the stage of design and technological preparation of production, which once again demonstrated its effectiveness in solving problems to reduce product weight.
Results. The main tasks of topological optimization were solved for the frame type constructions, such as the minimization of volume and mass under physical constraints, as well as the optimization of other parameters with given geometric constraints. As a result, the proposed method of reducing the weight of the product is improved, which due to rational design and technological measures ensured a 56 % reduction in the weight of the frame type structure from the original and reduced the complexity of the manufacturing process by 22 % due to its effective adaptation to new technological conditions.
Conclusions. The application of methods of topological optimization and rational establishment of design and technological constraints on products at the design stage can be very effective in solving problems of reducing the weight of products and optimizing manufacturing processes.
Assessment of Arterial Stiffness Using the Cardio-Ankle Vascular Index – What We Know and What We Strive for
Authors: Sumin A. N. , Shcheglova A. V.
Published: September 2021

Currently, the importance of assessing arterial stiffness as an integral indicator of cardiovascular risk, an indicator of arteriosclerosis, and a predictor of cardiovascular events has been demonstrated. The traditional indicator of arterial stiffness-pulse wave velocity-depends on the level of blood pressure, which makes it difficult to use it for dynamic assessment. The proposed new arterial stiffness index-the cardio-ankle vascular index (CAVI), does not depend on the level of blood pressure and is more convenient in practical use. CAVI has been widely used in clinical medicine for the past 15 years as an index for assessing cardiovascular diseases and risk factors, which has allowed for the expansion and deepening of research on this topic. This review focuses primarily on recent publications and new opportunities for evaluating vascular function using CAVI. The review provides information on solving methodological problems in evaluating CAVI, highlights the relationship between CAVI and future cardiovascular events, and provides cross-sectional data on the Association of CAVI with the presence of cardiovascular diseases and their risk factors. The results of studies on the effect of drug therapy and measures to control risk factors for cardiovascular diseases on CAVI are presented. While it remains unclear how much changes in CAVI over time can affect the forecast, research is currently being conducted in this direction. The use of CAVI also opens up new perspectives in the assessment of cardiovascular interactions, the study of vascular function in vasculitis and vascular injuries, as well as in geriatric medicine (concepts of premature vascular aging and excess vascular aging).
Pages of the History of Russian Medicine: Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor Alexey Petrovich Golikov – Doctor, Scientist, Citizen (to the 100th Anniversary of His Birth)
Authors: Boytsov S. A. , Stryuk R. I. , Golikova A. A. , Evdokimova A. G.
Published: September 2021

The main stages of the creative path of the scientist with a world-famous, professor, the Honored Worker of Science of the Russian Federation, Academician of the Russian Academy of Sciences Alexey Petrovich Golikov are presented in the article.
CESSATION OF FREE VIBRATIONS OF A NONLINEAR ELASTIC SYSTEM DUE TO VISCOUS RESISTANCE
Authors: Olshanskiy Vasiliy , Olshanskiy Stanislav
Published: September 2021

The paper deals with free vibrations of a system with power-law nonlinear elasticity subjected to power-law viscous resistance. The relation between the nonlinearity indices is determined when the impact of the viscous resistance force causes the vibrations to die away. In this case the vibrations are limited in time i.e. consist of a finite number of cycles analogous to a system with Coulomb dry friction. The research exploits the energy balance method. The periodic Ateb-functions are used to obtain an approximate formula for the work of dissipative force over a semi-cycle of vibrations. A recursive power-law equation for the vibration swings is derived from the condition of equality of the work to the potential energy change. By analyzing the change of the coefficient in the equation, which is related to the change of the semi-cycle number as well as the vibration swings, the condition for the equation to have no positive root is determined, which means that the vibrations die away. The condition is formulated in the form of an inequality. It is shown to generalize the results previously known. The theoretical inferences are verified by numerical integration of the nonlinear differential equation of motion. It is shown that under the conditions proposed in the paper the free vibrations consist of a finite number of cycles even if dry friction is absent from the system. Special cases are highlighted, when the approximate energy balance method results into exact computational formulae. The length of the cycles increases during the motion since it depends on the swing of damped vibrations in the essentially nonlinear system with rigid force characteristics considered.
Medial and Lateral Patellar Instability Leading to Medial Patellofemoral Ligament and Lateral Retinaculum Reconstruction
Authors: Stokey Phillip J. , Kennedy Hannah V. , Cross Jeffery M. , Sohn David H.
Published: September 2021

Case:

Combined medial and lateral patellar instability is exceptionally rare with only 3 reported cases to date. Here, we present the case of a 37-year-old White woman with multiple recurrent medial and lateral patellar instability. After failure of conservative care with bracing and therapy, she underwent surgical stabilization with medial and lateral allograft reconstruction.

Conclusion:

This case provides an example of the condition and successful surgical follow-up.
Clinical Outcome of Kissing Mosaicplasty for Treatment of Asymmetric Medial Tibiotalar Osteoarthritis
Authors: Sifen Lena , Van Steyn Peter , Romash Michael M.
Published: September 2021

Case:

We report a case of asymmetric medial ankle arthritis that was treated by medial malleolar osteotomy and oblique fibular osteotomy to expose and resurface both the medial talar dome and medial tibial plafond articular surfaces.

Conclusion:

This technique permitted a unique application of mosaicplasty in which osteochondral plugs were placed in a “kissing” orientation. The outcome seen here suggests the possibility of mosaicplasty as a viable option for treatment of localized ankle arthritis. In addition, this exposure technique is also applicable to treating isolated lesions of the medial tibial plateau.
Total Shoulder Arthroplasty in a Patient with Nail-Patella Syndrome
Authors: Kawashima Kenji , Terabayashi Nobuo , Asano Hiromi , Akiyama Haruhiko
Published: September 2021

Case:

A 62-year-old woman with a medical history of nail-patella syndrome (NPS) presented with chronic right shoulder pain. Physical examination revealed that her right shoulder had a restricted range of motion. Radiograph of the shoulder revealed arthritic changes with glenohumeral joint space narrowing, inferior humeral head osteophytes, and posterior glenoid wear. The patient was successfully treated with total shoulder arthroplasty (TSA). The patient had an uneventful postoperative course and was satisfied with her quality of life at the 30-month follow-up.

Conclusion:

TSA may be successfully performed with careful reaming of the hypoplastic glenoid fossa in patients with NPS.
Isolated Open Dislocation of the Capitate
Authors: Janish Tyler , Blotter Robert
Published: September 2021

Case:

We present a case of an isolated palmar, open dislocation of the capitate that occurred after a crush injury from an all-terrain vehicle rollover accident. The capitate was completely dislocated, rotated 90 degrees in the coronal plane with only soft-tissue attachments palmarly, and associated with a 4 cm open wound. A successful outcome was achieved via surgical reduction with percutaneous fixation. A follow-up at 44 months demonstrated good range of motion and no pain.

Conclusion:

Capitate dislocations are extremely rare. Prompt identification and surgical reduction can lead to successful outcomes.
Femoral Neck Over-Resection After Hip Arthroscopy Treated with Vascularized Fibula Autograft
Authors: Rodkey Daniel L. , Dickens Jonathan F. , Tintle Scott
Published: September 2021

Case:

We describe a case of femoroacetabular impingement syndrome treated with labral repair and arthroscopic femoral osteoplasty in a 30-year-old man. The case was complicated by resection of 50% of the femoral neck resulting in high risk of an impending femoral neck fracture. The patient was treated with a vascularized fibula autograft and internal fixation.

Conclusion:

Complications of femoral neck over-resection can threaten the viability and structural integrity of the hip joint but may successfully be treated with vascularized fibula autograft.
Teknologi, Informasi, Dan Komunikasi (Prinsip Dan Aplikasi Dalam Studi Pemikiran Islam)
Authors: Fahyuni Eni Fariyatul
Published: September 2021

Puji syukur penyusun panjatkan kehadirat Allah Swt, karena hanya atas rahmad, hidayah serta inayahNya buku ajar mahasiswa yang berjudul “Teknologi, Informasi, dan Komunikasi (Prinsip dan Aplikasi dalam Studi Pemikiran Islam)” dapat terselesaikan dengan baik. Buku ajar ini disusun dan dibuat berdasarkan materi-materi yang ada yang bertujuan agar dapat menambah pengetahuan dan wawasan siswa dalam belajar serta agar siswa juga dapat memahami nilai-nilai dasar Islami yang dikembangkan manusia dalam berpikir dan bertindak. Buku ajar ini membantu memahami sistem informasi yang dimulai dari perkembangan komputer, karena sistem informasi saat ini tidak bisa lepas dari perkembangan komputer. Selain itu beberapa konsep yang terdapat dalam sistem informasi juga dibahas dalam buku ini. Buku ajar ini lebih khusus diperuntukkan kepada para mahasiswa Universitas Muhammadiyah Sidoarjo yang sedang mengambil mata kuliah pembelajaran ICT atau mahasiswa universitas lainnya yang juga mempelajari mata kuliah yang serupa. Oleh karena itu beberapa contoh dan latihan yang ada pada buku ajar ini sebagian diambil dari dunia kemahasiswaan. Mudah-mudahan dengan mempelajari buku ini, para siswa akan mampu menghadapi masalah-masalah atau kesulitan-kesulitan yang timbul dalam pembelajaran dan dengan harapan semoga siswa mampu berinovasi dan berkreasi dengan potensi yang dimiliki. Kami menyadari bahwa dalam pembuatan buku ajar Teknologi Informasi dan Komunikasi ini masih terdapat Teknologi, Informasi, dan Komunikasi kekurangan sehingga penulis berharap saran dan kritik dari pembaca sekalian agar penulis dapat meningkatkan dan memperbaiki penyajian materi yang lebih baik dari sebelumnya. Akhir kata penulis ucapkan terima kasih.
Buku Ajar Statistika Dasar
Authors: Sulistiyowati Wiwik
Published: September 2021

Dengan mengucapkan puji syukur Allhamdullillah, atas berkat rahmat Allah SWT, kami dapat menyelesaikan bukuajar dengan judul “Statistik Dasar edisi Revisi”.Kami selaku tim penyusun mengucapkan terima kasih kepada semua pihak yang telah membantu kami selama proses pelaksanaan penyusunan sampai dengan terselesainya buku ajar ini. Kami menyadari, dalam buku ajar yang kami susun masih banyak kekurangan, sehingga kami berharap pembaca dan pengguna dapat memberikan masukkan/ kritik yang sifatnya membangun. Semoga apa yang kami hasilkan ini dapat memberikan manfaat bagi pembaca dan mahasiswa.
Front Matter
Authors: Owen Alun
Published: September 2021

Front Matter
Multi-reference Computational Method for De-novo Design, Optimization, and Repositioning of Pharmaceutical Compounds Illustrated by Identifying Multi-target SARS-CoV-2 Ligands
Authors: Alexandrov Vadim , Kirpich Alexander , Gankin Yuriy
Published: September 2021

In this work a novel computational multi-reference poly-conformational algorithm is presented for design, optimization, and repositioning of pharmaceutical compounds. The algorithm searches for candidates by comparing similarities between conformers of the same compound and identifies target compounds whose conformers are simultaneously “close” to the conformers for each of the compounds in a reference set. The reference compounds can have very different MoAs, which directly and simultaneously shapes the properties of the target candidate compounds. The algorithm functionality has been validated in silico by scoring ChEMBL drugs against FDA-approved reference compounds which either had the highest predicted binding affinity to our chosen SARS-COV-2 targets or confirmed to be inhibiting such targets in-vivo. All our top scoring ChEMBL compounds also turned out to be either high-affinity ligands to the chosen targets (as confirmed separately in other studies) or showing significant efficacy in-vivo against those selected targets.In addition to method validation in silico search for new compounds within two virtual libraries from the Enamine database is presented. The library’s virtual compounds have been compared to the same set of reference drugs that we used for validation: Olaparib, Tadalafil, Ergotamine and Remdesivir. The large reference set of four potential SARS-CoV-2 compounds have been selected, since no drug has been identified to be 100% effective against the virus so far, possibly because each candidate drug was targeting only one particular MoA. The goal here was to introduce methodology for identifying potential candidate(s) that cover multiple MoA-s presented within a set of reference compounds.
Novel Combination of Quaternary AgFeNi2S4 Semiconductor In Graphene-TiO2 Nanocomposite For The Enhanced Electrophotocatalytic Reduction of CO2
Authors: Otgonbayar Zambaga , Oh Won Chun
Published: September 2021

For reduction of CO2 into hydrocarbon fuels, a quaternary AgFeNi2S4 semiconductor combined in Graphene-TiO2 nanocomposite material was synthesized via the Pechini method. The catalytic activity of the photocatalyst for photocatalytic and electrochemical CO2 evolution into hydrocarbon fuels was tested. The methanol yield under UV light was 8.679, 6.349, and 4.136 %, and the methanol yields under visible light were 6.291, 4.738, and 2.339 %, respectively. The stability and reusability of the photocatalyst remained high after a 4-cycle recycling test without a decrease in yield of the final photocatalytic CO2 reduction product. The enhanced photoreduction of CO2 through the as-prepared ternary photocatalyst can be ascribed to the catalyst's conformation and low recombination rate. In electrochemical CO2 reduction, the Faraday efficiency is the main parameter that defines the performance of the working electrode and the evolution of methanol. The Faraday efficiency of AFNSGT ternary nanocomposite was 44.25 %; this is an increase in the value of the Faraday efficiency, which proves that the design of the new nanocomposite successfully increases the activity of the working electrode and has a positive effect on the electrochemical reduction of CO2. The photocatalytic and electrochemical CO2 reduction data show that the preparation method, morphological state, and charge carrier properties of the photocatalyst are important for the catalytic activity and efficiency of the methanol evolution pathway.
Effects of Extended Feeding of Florfenicol Coated Medicated Diets on the Safety, Serum Biomarkers and Blood Cells Morphology of Nile Tilapia Oreochromis Niloticus (L.) Juveniles
Authors: Bardhan Avishek , Abraham Thangapalam Jawahar , Singha Jasmine , Saha Suchismita , Sarker Sudeshna , Patil Prasanna Kumar
Published: September 2021

Tilapia is one of the most consumed farmed fish, which requires the use of antibiotics in certain phases of its production. This study assessed the safety of 30 days of oral florfenicol (FFC)-dosing at 0-10 times the therapeutic dose (1X: 10 mg/kg biomass/day) in Oreochromis niloticus juveniles. Behavioural changes, feed consumption, mortality and biomass were evaluated. Besides, the levels of serum glucose, calcium, chloride, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood cell morphology were determined at scheduled intervals. The 30 days of oral FFC-dosing caused 3.33% (1X) to 18.33% (10X) mortalities, reduced feed intake and biomass in a dose-dependent manner. The fish fed the therapeutic dose recorded 1.25 folds increase in biomass; while the control group recorded 1.45 folds increase in 30 days. No significant erythrocyte morphological alterations were observed in the 1X group compared to the control. However, marked morphological alterations like tear-shaped, spindle-shaped and degenerative erythrocytes in higher dosing groups indicated FFC cytotoxicity. All the serum biomarkers of O. niloticus increased significantly on day 10 and day 30 FFC-dosing in a dose-dependent manner, except for calcium and chloride, which reduced significantly during the dosing period. Within 2 weeks of suspension of FFC-dosing, the serum biomarker levels became normal except for alkaline phosphatase and creatinine. The recovery of biomass, feed intake, serum biomarker levels and erythrocyte morphological changes suggested that the FFC induced changes are reversible. This study has, thus, proclaimed the safety of FFC at the therapeutic dose in O. niloticus.
Tumor Angiogenesis at Baseline Identified by 18F-Alfatide II PET/CT May Predict Survival Among Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy
Authors: Wei Yuchun , Qin Xueting , Liu Xiaoli , Zheng Jinsong , Luan Xiaohui , Zhou Yue , Yu Jinming , Yuan Shuanghu
Published: September 2021

Background The study investigated the predictive value of tumor angiogenesis observed by 18F-ALF-NOTA-PRGD2 II (denoted as 18F-Alfatide II) positron emission tomography (PET)/computed tomography (CT) before concurrent chemoradiotherapy (CCRT) for treatment response and survival among patients with locally advanced non-small cell lung cancer (LA-NSCLC).Methods Patients with unresectable stage IIIA or IIIB NSCLC (AJCC Cancer Staging 7th Edition) who received CCRT were included in this prospective study. All patients had underwent 18F-Alfatide PET/CT scanning before CCRT, and analyzed parameters included maximum uptake values (SUVmax) of primary tumor (SUVP) and metastatic lymph nodes (SUVLN) and mean uptake value of blood pool (SUVblood). Tumor-to-background ratios (TBRs) were calculated. The ratios of SUVP to SUVblood, SUVLN to SUVblood, and SUVP to SUVLN were denoted as TBRP, TBRLN, and T/LN. Short-term treatment response, progression-free survival (PFS), and overall survival (OS) were evaluated.Results Of 38 enrolled patients, 28 completed CCRT. SUVP, SUVLN, TBRP, TBRLN and T/LN showed significant correlation with PFS (all P<0.05). SUVP was negatively correlated with OS (P=0.005). SUVP and TBRP were higher in non-responders than in responders (6.55±2.74 vs. 4.61±1.94, P=0.039; 10.49±7.58 vs. 7.73±6.09, P=0.023). Exploratory receiver operating characteristic curve analysis identified TBRP (area under the curve [AUC]=0.764, P=0.018), with a cutoff value of 6.52, as the only parameter significantly predictive of the response to CCRT, with sensitivity, specificity, and accuracy values of 71.43%, 78.57%, and 75.00%, respectively. ROC curve analysis also identified SUVP (AUC=0.942, P<0.001, cutoff value 4.64) and TBRP (AUC=0.895, P=0.001, cutoff value 4.95) as predictive of OS with high sensitivity (84.21%, 93.75%), specificity (100.00%, 66.67%), and accuracy (89.29%, 82.14%).Conclusions Evaluation of tumor angiogenesis by 18F-Alfatide Ⅱ at baseline may be useful in predicting the short-term response to CCRT as well as PFS and OS in patients with LA-NSCLC.
Analysis of E-mental Health Research: Mapping the Relationship between Information Technology and Mental Healthcare
Authors: timakum tatsawan , Song Min , Xie Qing
Published: September 2021

Background: E-mentalhealthcare is the convergence of digital technologies with mental health services. It has beendevelopedto fill a gap in healthcare for people who need mental wellbeing support and may never otherwise receive psychological treatment.This study aimed to apply text mining techniques to analyze the huge data of e-mental health researches and to report on research clusters and trends as well as the co-occurrence of biomedical and the use of information technology in this field.Methods: The e-mentalhealth research data was obtainedfrom 3,663 bibliographicrecords from Web of Science (WoS)and 3,172 full-text articlesfrom PubMed Central (PMC). The text mining techniques utilized for this study includedbibliometric analysis, information extraction, and visualization.Results: The e-mental health research topic trendsprimarily involvede-health care services and medical informatics research. The clusters of research comprise 16 clusters, which refer to mental sickness, ehealth, diseases, IT, and self-management. Based onthe information extraction analysis, in the biomedical domain, a “depression” entity was frequently detected and it pairs with other entities in the network with a betweenness centrality weighted at 0.046869 (eg. depression-online, depression-diabetes, depression-measure, and depression-mobile).The IT entity-relations of “mobile” were the most frequently found(weighted at 0.043466). The top pairs are related to depression, mobile health, and text message.Conclusions: E-mental health research trends focused on disease related-depression and using IT for treatment and prevention, primarily via online and mobile devices. Producing AI and machine learning are also being studied for e-mental healthcare. The results illustrate that physical sickness is likely to cause a mental health problem and identify the IT that was applied to help manage and mitigate mental health impacts.