bluuebunny/crossref_metadata_2025 huggingface dataset:
MICROVASCULAR ANGINA IN PATIENTS WITH NON-STENOTIC CORONARY LESIONS
Authors: Marushko E. Yu. , Mankovsky G.B. , Dzhun Ya.Yu.
Published: December 2024

Background. According to various literature data, from 1/3 to 1/2 of patients whose complaints correspond to a typical picture of angina pectoris do not have obstructive lesions of the coronary vessels during invasive coronary angiography. These patients belong to the INOCA group. The main pathogenic mechanism of this problem is coronary microvascular dysfunction (CMD), which manifests as a violation of the coronary vasodilation reserve.
Aim: to evaluate reserve of coronary vasodilatation and to determine the echocardiographic signs of myocardial ischemia in patients with angina pectoris and non-stenotic atherosclerosis of the coronary vessels according to the data of invasive coronary angiography.
Materials and methods. We included 311 patients with a clinical diagnosis of «CAD: angina pectoris» who underwent invasive coronary angiography and who had intact coronary arteries or non-stenotic lesions were consecutively examined. Coronary microvascular dysfunction (reduced iCFR index) occurred in 78.1% of patients with coronary heart disease without hemodynamically significant lesions of the coronary arteries. In those patients, a significant decrease in the GLS indicator was observed -15.2±0.5% compared to the baseline -20.5±0.4% mainly due to segmental disorders - signs of myocardial ischemia.
Conclusion. Stress echocardiography with strain imaging during intravenous dipyridamole was an effective method for simultaneously detecting violation of the coronary vasodilatation reserve and confirming the myocardial ischemia.
ASSESSMENT OF MORTALITY RISKS FROM COVID-19 IN HOSPITALISED VACCINATED PATIENTS AND PATIENTS AFTER A PREVIOUS ILLNESS DEPENDING ON AGE
Authors: Riaba O.V. , Golubovska O.A. , Chalyy K.O.
Published: December 2024

Background. According to numerous studies, vaccination is an effective method in preventing hospitalisation and mortality from COVID-19. However, COVID-19-related deaths have also been reported among fully vaccinated individuals.
Aim: to compare the risks of mortality from coronavirus disease 2019 in hospitalised vaccinated patients and patients who have not been vaccinated before after a previous illness of different sexes and different age groups.
Materials and methods. the study included 220 hospitalised patients who were divided into two groups: vaccinated patients (n=129) and patients with a history of COVID-19 (n=91). All patients were divided into three groups by age: ≤39 years, 40-69 years, ≥70 years. All patients were admitted with laboratory-confirmed SARS-CoV-2 by PCR or a rapid qualitative antigen test.
Results. in the age group ≤39 years, no deaths from COVID-19 were recorded. When comparing the incidence of deaths among hospitalised patients after a previous illness (n=36) and vaccinated patients (n=58) in the age group 40-69 years, no statistically significant risk difference was found (p=0.742). The risks of mortality among hospitalised patients with a history of COVID-19 (n=46) and vaccinated patients (n=58) in the age group ≥70 years were statistically significantly different (p=0.011). At the same time, the risk in patients after a previous illness  was 22.3% higher than in the vaccinated group (95%CI 6.5-37.7).
CLINICAL UTILITY OF MULTIMODAL IMAGING AND NEURO-MONITORING IN AWAKE CRANIOTOMY FOR LOW-GRADE GLIOMA: A CASE REPORT AND LITERATURE REVIEW
Authors: Chaulagain Dipak , Smolanka Volodymyr , Smolanka Andriy , Havryliv Taras
Published: December 2024

Insular gliomas pose a therapeutic challenge due to their intricate anatomy and proximity to eloquent brain regions. Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) tractography are useful ways to learn about the insular region's neuronal connections and how they work before surgery. The purpose of this case report is to show how awake craniotomy, with intraoperative neuromonitoring (IONM), can be used to remove low-grade gliomas, especially from the insular region. By carefully drawing functional boundaries using fMRI and DTI data collected before surgery, surgical methods were created to protect important brain areas as much as possible while removing as much of the tumor as possible. A 31-year-old male presented with a 5-month history of headaches, seizures, and right-sided numbness. Neurological examination revealed difficulty with word finding and organization but no overt speech deficits. An MRI revealed a non-enhancing lesion in the left frontotemporal region. An awake craniotomy was conducted to protect language centres and brain function during surgical resection, with guidance from DTI, fMRI, and IONM.The study underscores the importance of integrating advanced imaging modalities with intraoperative techniques to optimize surgical outcomes for insular gliomas. To maximize success and minimize postoperative complications, a comprehensive understanding of tumor biology, neuroanatomy, and patient-specific factors is imperative. Incorporating preoperative fMRI and DTI into surgical planning enhances the accuracy and efficacy of awake craniotomy procedures. Further research is warranted to validate these findings and refine treatment strategies for insular gliomas.
Soqtapata
Authors: Armas Cálasich Juan
Published: December 2024

Este estudio busca verificar si un modelo particular de concesión para la conservación en la Amazonía peruana corresponde al modelo de “ecología integral” que se plantea en la Encíclica Laudato si del papa Francisco. Para ello se describe este tipo de concesión, su historia y los desafíos que presenta y se la compara con dos modelos de organización exitosos que hacen énfasis en la educación y no solo en el mercado para conseguir el desarrollo humano. Nos limitamos a estudiar un caso puntual y habría que validar si es replicable a otras realidades. Pensamos que la originalidad de este trabajo radica en que se parte de una situación real y luego se verifica si refleja lo planteado en la Encíclica. Se concluye que dicho modelo tiene la capacidad de conseguir una ecología integral si logra superar sus retos de sostenibilidad en un contexto de deforestación cada vez más difícil.
Perencanaan Bisnis Neja.Net (Teaching Factory SMKN Jatiluhur)
Authors: Anjarsari Renita , Dora Yenny Maya
Published: December 2024

Neja.Net adalah perusahaan startup yang menyediakan layanan internet cepat dan stabil bagi rumah tangga, civitas akademik, dan bisnis lokal. Layanan ini mencakup berbagai paket internet, mulai dari kebutuhan dasar hingga kecepatan tinggi untuk penggunaan bisnis. Neja.Net bersaing dengan kompetitor melalui pelanggan setia dan produk yang dapat dikembangkan sesuai kebutuhan pasar serta kemajuan teknologi. Analisis keuangan menunjukkan bahwa Neja.Net memiliki performa keuangan yang baik, memungkinkan operasional yang sehat dan berkelanjutan. Dukungan dari mitra dan distributor dalam pemasaran serta keuangan memperkuat posisi Neja.Net untuk menyediakan layanan internet dedicated dengan harga yang kompetitif dan kualitas unggul dibandingkan internet broadband. Kebutuhan dana awal untuk Neja.Net adalah Rp. 154.298.000, dengan prediksi Break Even Point (BEP) pada tahun kedua. Perusahaan ini memiliki potensi besar untuk berkembang jika dikelola dengan baik, dengan proyeksi keuntungan mencapai Rp. 1.000.102.000 dalam lima tahun pertama. Kerjasama dengan mitra melalui program PKL siswa, magang, kerjasama lulusan, dan pelatihan memberikan simbiosis mutualisme yang menguntungkan. Rencana tindakan mencakup lima tahap: persiapan dan pengembangan infrastruktur, rekrutmen dan pelatihan staf, peluncuran dan operasional, pengembangan dan ekspansi, serta konsolidasi dan keberlanjutan. Evaluasi berkala dan inovasi berkelanjutan diharapkan meningkatkan layanan dan mempertahankan daya saing. Potensi risiko meliputi risiko keuangan, teknologi, keamanan siber, dan regulasi, yang memerlukan mitigasi yang efektif untuk menjamin kelangsungan operasional.
Analisis Deskriptif Komparatif antara Sistem Manajemen K3 Wise Square dengan Sistem Manajemen K3 menurut PP No. 50 Tahun 2012 Di PT ABC
Authors: Rahayu Anugrah Restu , Sembiring Edison , Soehatmanramli Soehatmanramli , Sugiarto Sugiarto
Published: December 2024

Penerapan sistem manajemen K3 pada perusahaan merupakan hal esensial sebagai penunjang keselamatan dalam pelaksanaan produksi dan setelahnya. Pada penelitian ini penulis membandingkan penerapan Sistem Manajemen K3 pada PT ABC dengan panduan dalam Peraturan Pemerintah RI No. 50 Tahun 2012. Jenis penelitian yang digunakan pada tesis ini adalah penelitian deskriptif melalui pendekatan kualitatif dari analisis perbadingan implementasi Sistem Manajemen K3 WISE di PT. ABC dengan PP No. 50 Tahun 2012 tentang penerapan Sistem Manajemen Keselamatan dan Kesehatan Kerja. Analisi yang dilakukan mendapati bahwa penerapan safety culture sesuai yang ada pada WISE telah melengkapi semua kriteria yang diperlukan oleh panduan SMK3 yang ditetapkan dalam PP No. 50 Tahun 2012. Dengan ini maka PT ABC telah mengikuti aturan pemerintah dalam upaya penerapan SMK3 dalam dunia industri dengan arahan yang disesuaikan pada WISE. Meski dimikian PT ABC perlu melakukan rapat koordinasi terkait relevansi WISE dengan kebijakan pemerintahan dan perundangan di Indonesia agar PT ABC tetap sejalan dengan iklim K3 Indonesia.
Implementasi Ruang Ilmiah dalam Perspektif Teori Humanistik pada Pembelajaran Jarak Jauh Mahasiswa Sentra Layanan Universitas Terbuka (SALUT) Kota Batu
Authors: Batti Steviani , Ginting Andi Lopa , Suwarno Asmawati
Published: December 2024

Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui terkait ruang ilmiah yang diciptakan oleh Universitas Terbuka Salut Kota Batu bagi mahasiswa dengan mekanisme pembelajaran jarak jauh dalam perspektif teori humanistik. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Lokasi yang dipilih dalam penelitian ini adalah di Sentra Layanan Universitas Terbuka Kota Batu. Data yang digunakan dalam penelitian ini didapatkan melalui wawancara yang dilakukan kepada Pengelola SALUT dan mahasiswa UT. Hasil penelitian ini menunjukkan bahwa Pembelajaran yang dilakukan pada Salut Kota Batu Universitas Terbuka sangat sulit menjalin interaksi dengan lingkungan. Hal ini disebabkan karena mereka sebagai mahasiswa dihadapkan pada kemajuan teknologi seingga dalam menghubungan karak antar mereka memanfaatkan teknologi tersebut untuk mempersempit jarak yang ada. Beberapa penghambat yang tidak mampu membentuk ruang ilmiah mahasiswa Universitas terbuk adalah keterbatasan interaksi mengingat mekanisme pembelajaran yang dilakukan secara online sehingga tidak memberikan ruang gerak kepada mahasiswa untuk berinteraksi dengan mahasiswa lainya. Selain itu,  ketiadaan interaksi bagi mahasiswa tuton terhadap mahasiswa sehingga perkuliahan hanya menekankan pada teoritis dan tidak memberikan pandangan atas interaksi, lingkungan dan rasa sosial yang seharusnya terjalin dalam mekanisme pembelajaran.
Evaluating Thermal Comfort in Tropical Environments: A Parametric Study of Hypothetical Urban Morphology in Jakarta
Authors: Krishna Bhakta Gede , Syafii Nedyomukti Imam
Published: December 2024

The significant growth of cities worldwide led to more than half of the global population residing in urban areas, with urbanization projected to have reached 68% by 2050. However, this growth also brought negative impacts on urban environments, one of which was the Urban Heat Island (UHI) effect, where urban areas with dense buildings experienced higher temperatures than their suburban counterparts. Urban morphology, which focused on the formation and transformation of urban areas, served as a crucial indicator for urban planning, information management, and urban climate applications. The increased urban air temperatures significantly influenced the outdoor thermal comfort (OTC) of urban residents. This study aimed to establish a relationship between urban morphology and outdoor thermal comfort in tropical climates using the Universal Thermal Climate Index (UTCI) to assess thermal comfort. The research findings indicate that larger Building Site Coverage leads to lower UTCI values, suggesting improved thermal comfort. Conversely, smaller building site coverage results in higher UTCI values, indicating less favorable thermal comfort. Simulation analysis of Outdoor Thermal Comfort reveals a distribution of cooler thermal conditions between buildings on the east and west sides, while the north and south sides experience warmer thermal conditions.
Motivation of milking high productivity cows under the conditions of robotic sys-tems
Authors: Lutsenko M. M. , Popkov V. V.
Published: December 2024

Scientific research was carried out at the TDV “Terezine” farm of Bila Tserkva district, Kyiv region, on a newly created dairy farm for 500 cows with robotic milking systems of the De Laval Company. The herd of cows has been housed in a room with new volume-planning and technological solutions of 36 m wide and 10.5 m high. In the center of the room are eight robotic systems where the animals enter for milking at their request. The article highlights the research results into the structure of the milking herd of a dairy farm. It has been established that at the farm with robotic milking systems for 500 cows, there are animals with 1–6 lactations. The most significant part of the herd consists of cows of the first lactation (142 heads) and the smallest one - of the sixth lactation (11 heads). The parts of cows of the third, fourth, and fifth lactation are, respectively, 3rd – heads, 4th – 45 heads, and 5th – 28 heads. Such a structure of the herd indicates that the cows are highly productive. We studied the milking frequency of cows of different ages under robotic milking depending on the lactation period and their productivity. It has been shown that the technology of milking cows using robotic milking systems radically differs from that of milking on traditional machines. It was found that first-born cows had the lowest number of milking times per lactation (2.17 times), and cows of the second lactation had the highest (2.24 times) with a gradual decrease in the third (2.21 times) and the fourth (2.18 times). The decrease in the frequency of milking in the third and fourth lactation is because as the age of lactating cows increases, milk productivity increases, and, accordingly, the size of the udder, which does not require frequent release. Studies have proven that the higher the daily milk yield, the more often the cow comes to be milked. So, the first-born cows with an average daily milk yield of 10–20 kg go to milking 2.12 times, and with a productivity of 20–30 kg, the number of milking increases by 0.1 time, and with daily milk yields of 31–40 kg and 41–50 kg, the need in milking increases by 0.35 and 0.43 times. It has also been established that the need for milking is 0.52 times higher in animals of second lactation than in first-born cows. It has also been established that when the daily productivity of cows increases, the intervals between milking are shortened. With a daily milking of 10–20 kg, the average interval between milking is 10.5 hours, and with a milking of 40 kg and above – 7.3 hours. The most extended interval between milking is observed at night between the evening and morning milking. Based on the obtained research results, the farm's work schedule is suggested to be adjusted.
Canis therapy: implementation needs and development problems in Ukraine
Authors: Krempa N. Yu. , Gutyj B. V. , Kozenko O. V. , Dvylyuk I. V. , Magrelo N. V. , Klym H. V. , Vus U. M. , Vysotskyi A. O. , Martyshuk T. V. , Popadiuk S. S.
Published: December 2024

From scientific medical-pedagogical and veterinary-cynological literature sources, it is known that one of the methods of positive psychosocial and physio rehabilitation influence on people who need it is canine therapy, which through specially trained and certified dogs has a beneficial effect on the patient. Canine therapy is one of the types of auxiliary therapy for complex treatment, which includes using dogs to improve the patient's social, emotional, or cognitive functions. The purpose of the work is to expand understanding and highlight the competencies of influence of both the direction of activity and the term “canine therapy,” to monitor the needs of its implementation and development problems in Ukraine, to study the features of the regulatory and legal side of the organization of human-animal interaction (HAI) and to clarify the main concepts and format of the work of therapy dogs. It has been established that the requirements for the professionalism of human-animal interaction (HAI) are that to achieve the most effective constructive and therapeutic effect, it is necessary to know the peculiarities of the formation and functioning of not only the human psyche, psychology, and zoopsychology but also the availability of certified specialists (cynologist, therapist, psychologist, rehabilitation specialist, speech therapist, defectologist). Considering that the canine therapy area of activity is only developing, and unfortunately, there are no regulatory and legal recommendations regarding participants and requirements for its organization that would guarantee safety and compliance in the sanitary-hygienic and legal fields of implementation, specialists in the provision of canine therapy services should rely on the provisions of the “White Book” in their work, which is an official document and appeal of the International Association of Human-Animal Interaction Organizations (IAHAIO). Its goal is to form a respectful and responsible attitude towards people and animals during work and interaction between them. The concepts of canis therapy, “One Health” and “One Wellbeing,” spelled out in the regulations, significantly impact LTV methods, which are united by a common goal to preserve and improve human health, well-being, and functioning.
Effects of the Rule Change From Three to Five Substitutions in the Bundesliga
Authors: Dilger Alexander , Vischer Lars
Published: December 2024

The COVID-19 pandemic has led to massive restrictions and changes in many different areas of life, including professional sports. In football, many games were cancelled and then, with the unchanged maximum of three time-outs, five substitutions were allowed instead of three—initially temporarily, now permanently. We analyze the impact of this rule change on coaches’ substitution decisions, comparing 836 games with three possible substitutions and 1,000 games with five possible substitutions in the six seasons from 2017/2018 to 2022/2023 of the Bundesliga (first division of German men’s football). In addition to team statistics, data on substitutions were collected. The results show that the rule change has changed the behavior of the coaches in terms of the number of substitutions made and the timing of substitutions. While using more of the allowed substitutions is good for the home team, the home bias is reduced by the rule change
ЗАСТОСУВАННЯ ВЕЛИКИХ МАСИВІВ ДАНИХ (BIG DATA) ДЛЯ ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ДЕРЖАВНОГО УПРАВЛІННЯ В УКРАЇНІ
Authors: Скібіна Т. І.
Published: December 2024

У сучасному світі можливість використання великих масивів даних (Big Data) дозволяють реалізувати кращі стандарти ефективності, транспарентності та якості обслуговування громадян. Впровадження управлінських рішень в державній та суспільних сферах заснованих на аналізі великих масивів даних не лише сприяють оптимізації витрат та покращенню якості послуг, але й відкривають шлях до значного збільшення рівня прозорості у діяльності державних установ, підвищення рівня ефективності публічного управління, є основою для впровадження інновацій. У статті досліджено потенціал та перешкоди використання великих масивів даних при прийнятті рішень в публічному управлінні України. Визначена ключова роль аналізу великих масивів даних в обґрунтованому прийнятті рішень, покращенні ефективності управлінських процесів, підвищенні якості обслуговування громадян та забезпеченні прозорості діяльності державних установ. Основними аспектами дослідження є аналіз поточного стану використання великих масивів даних у публічному секторі, ідентифікація ключових викликів та можливостей, а також формулювання рекомендацій щодо ефективного впровадження цих технологій. Стаття висвітлює різноманітність джерел великих масивів даних, включаючи державні реєстри, електронне урядування, соціальні мережі та інші, що є основою для аналізу та прийняття обґрунтованих управлінських рішень. Досліджено переваги застосування аналізу великих масивів даних, такі як оптимізація витрат, покращення якості послуг та збільшення рівня прозорості у діяльності державних установ. Стаття також розглядає ключові виклики, з якими стикається Україна при впровадженні аналізу, зберігання, передачі великих масивів даних, такі як фінансова підтримка для створення необхідної інфраструктури, захист персональних даних, недостатня нормативна база та кадрові проблеми. Доведено, що забезпечення кібербезпеки та дотримання правових норм щодо захисту особистих даних є критичними аспектами для використання великих масивів даних. Запропоновано ряд рекомендацій, включаючи інвестиції у кадровий потенціал та технологічний розвиток, стандартизацію форматів даних, вдосконаленням правового регулювання, покращення інфраструктури, співпрацю з міжнародними партнерами для обміну кращими практиками, формування та залучення кваліфікованих кадрів. У статті проведено стратегічний аналіз з використанням моделі "5V" для підвищення точності та цінності у роботі із великими масивами даних у державному управлінні. Основними показниками моделі визначено: обсяг, швидкість, різноманітність, правдивість, значення. Встановлено, що успішне впровадження урахування аналізу великих масивів даних можливе лише за умови усунення системних перешкод і створення сприятливого середовища для їхнього розвитку. У статті підкреслено необхідність активного впровадження аналізу великих масивів даних у державне управління України як стратегічного напрямку для досягнення цифрової трансформації, а також надає базовий фреймворк для подальших досліджень та практичних застосувань в цій області.
Збірник освітніх кейсів із фізіології харчування та безпеки праці кухарів: практичний посібник
Authors:   Інститут професійної освіти НАПН України, Гайдук Ольга , Дрозіч Ірина , Каленський Андрій , Лапа Оксана
Published: December 2024

У практичному посібнику обгрунтовано методичну систему розроблення та застосування екоорієнтованих педагогічних технологій у професійній (професійно-технічній) освіті; функції, переваги та недоліки використання кейс-методу в екоорієнтованій професійній підготовці майбутніх кухарів; викладено практичні рекомендації щодо розроблення освітніх кейсів екологічного спрямування з санітарії, гігієни, фізіології для професійно-теоретичної підготовки майбутніх кухарів та формування їхньої енергоефективної культури. Адресовано керівникам, викладачам, майстрам виробничого навчання, методистам навчально (науково)-методичних центрів (кабінетів) професійно-технічної освіти.
توجيه متشابه بعض ألفاظ القرآن الكريم
Authors: Abdoul Karim Toure  , Mesbahul Hoque
Published: December 2024

This study engages with a crucial aspect of Quranic exegesis that has drawn scholarly attention since the earliest periods of codification through to the contemporary era. Although much debate has revolved around whether certain Quranic terms are genuinely synonymous or simply repetitive, no definitive consensus has emerged. Rather than revisiting the well-trodden argument over the existence or non-existence of synonymy in the Qurʾān, this research focuses on selected words commonly presumed to be synonyms. By closely examining their usage and context, the study demonstrates that these terms do not share identical meanings. Instead, their semantics shift according to their placement within each verse, thereby challenging long-held assumptions and offering fresh insights into the Qur’anic text.
مشكل حديث "إنما الشؤم في ثلاثة: الفَرَس، والمرْأَة، وَالدَّار" وتحليل الأبعاد التأويلية
Authors: Zakir Aras  , Mohammed Abullais al-Khairabadi
Published: December 2024

This study examines Prophetic hadiths related to ill omen (ṭiyarah) and superstition, focusing on the variability of their narrations and interpretive approaches. The findings indicate that hadiths concerning ill omen in horses, women, and houses differ in degrees of authenticity and associated conditions, suggesting that their applicability is context-dependent rather than universal. When presented as commentary, these narrations highlight the need for careful scrutiny to reconcile differences and prevent apparent contradictions. The analysis demonstrates that ill omen and superstition do not reside inherently in the nature of things. Rather, Allah created all things for humanity’s benefit, establishing a baseline of permissibility and utility. Perceiving objects or events as inherently inauspicious reflects an unfounded negative presumption about Allah’s nature, which stands in opposition to Islamic teachings that encourage trust (tawakkul) in Him. Additionally, this study underscores the importance of critically evaluating hadith commentaries that attribute ill omen to external factors—such as an unfavourable neighbour—arguing that such interpretations may not align with the original text’s purpose and context. The emphasis on horses, women, and houses, frequently encountered in daily life, appears intended as a cautionary directive rather than an absolute statement of ill omen. ʿĀʾishah’s astonished reaction to Abu Hurayrah’s narration illustrates the need to consider variant transmissions and understandings of the hadith. Her perspective, supported by scholars like Ibn Qutaybah and Imam al-Ṭaḥāwī, merits significant consideration for a more accurate interpretation. Integrating these insights with contemporary scholarly approaches can lead to a deeper and more nuanced understanding of these hadiths.
التفسير المقارن للفظ ﴿‌ٱلۡفُرۡقَانَۗ﴾ في قوله تعالى: وَأَنزَلَ ‌ٱلۡفُرۡقَانَۗ
Authors: Aya Fekry Abdelaziz  , Mohamed Abdelaatif Abde-laati
Published: December 2024

This study investigates the meaning of the Qur’ānic term “al-Furqān” as it appears in verse 4 of Sūrah Āl ʿImrān. It seeks to answer the core question: How should “al-Furqān” be understood in the phrase “wa anzala al-furqān” (and He sent down the Criterion)? By examining and categorising the interpretations of both early and contemporary Qur’anic exegetes, the study clarifies their approaches according to distinct exegetical methodologies. It then identifies the interpretation most consistent with established principles and evidence. Methodologically, the research employs the inductive approach to collect various interpretations, the analytical approach to examine these positions, and the comparative approach to weigh their merits against one another. The analysis reveals fourteen possible understandings of “al-Furqān.” Of these, six are considered unlikely, while eight are interpreted as complementary rather than contradictory meanings. The study concludes that the term “al-Furqān” is best understood as encompassing this broader spectrum of meanings, rather than being confined to one narrow definition. This integrative perspective is supported by contextual analysis of the verse and by exegetical insights, including comprehensive phrases offered by some scholars that reflect the term’s multifaceted significance. In light of these findings, the study recommends further application of comparative interpretive methodologies to investigate other Qur’anic terms and phrases with disputed meanings, thereby fostering a more nuanced understanding of the divine intent.
أساليب الملأ في مواجهة دعوة الأنبياء في القرآن الكريم: دراسة دلالية بيانية
Authors: Ali Abdallah Ahmad Al-Hrerat
Published: December 2024

The study aimed to explain the methods and role of elites in confronting Prophets’ calls in the Holy Quran, as well as the rhetorical connotations they contained. It also aimed to identify and address these methods, and to clarify the extent of their influence on the call. The researcher employed the inductive method to track these methods, and the deductive method to infer the meanings inherent in the word's use, the Quranic structure, the Prophets’ story, and the rhetorical features. The study elucidated the strategies employed by Elites in response to the call, illustrating them through the biographies and stories of prophets. This provided preachers with a framework to follow and emulate, guiding them in addressing the call’s consequences and responsibilities, and in promoting positive values within societies that steer clear of despair and hopelessness. The study concluded with a series of significant findings, the most significant of which was that the Holy Qur'an contains a variety of elite methods, including the use of vocabulary and structures. These methods demonstrate the extent of elite influence in achieving a surface aversion to the call and its failure to achieve its true goal, as well as the wisdom of the prophets in rejecting these methods in order to uphold the laws of the struggle between good and evil.
Implementasi Surah al-Hujurat Bagi Membendung Konflik dan Melestarikan Hubungan Baik di Tempat Kerja
Authors: Yasir Ramlee
Published: December 2024

Sustaining positive relationships in the workplace is a crucial challenge that demands careful consideration, as each employee has personal goals that may differ from those of their colleagues, potentially leading to conflicts. Uncontrolled conflicts resulting from strained relationships can have a clear negative impact on performance and work quality. Thus, well-defined guidelines are essential for enhancing workplace interactions and ensuring that all employees are aware of the ethical standards that must be upheld during their duties. This paper examines the implementation of various strategies in the workplace to foster and maintain positive relationships, drawing upon the interpretation of selected verses from Surah al-Hujurat. The guidelines outlined in this Surah emphasise the importance of respecting authority, adhering to ethical communication practices, promoting a culture of cooperation and self-reflection, and valuing diversity in character. By internalising these principles, the workplace can evolve into a more positive and productive environment, underpinned by mutual understanding and strong collaboration among employees.
Integriti Menurut Perspektif Wahyu: Kajian Peranannya dalam Pembangunan Lestari Islam
Authors: Siti Sarah Izham  , Noor Aznaim Abd Latif  , Siti Nor Amira Mohamad  , Shahirah Said
Published: December 2024

Islam is a holistic religion that integrates all aspects of life, including worship, adherence to halal and haram principles, interpersonal relationships, and the human connection with nature. Allah entrusts humans as caliphs on Earth with responsibilities that extend beyond leadership, encompassing stewardship and the pursuit of success in this world and the hereafter. For Muslims, the Quran and Hadith provide guidance on achieving success, emphasising the significance of environmental conservation as an essential principle of Islamic teachings. This study aims to contribute to the ongoing discourse on sustainable development in Islam by exploring the key values and behaviours necessary for achieving conservation in accordance with Islamic principles. Utilising a qualitative methodology that includes document analysis and semi-structured interviews, the researchers identify honesty as a pivotal element in promoting sustainable development. The findings emphasise that instilling moral uprightness, beginning with familial education, is fundamental for fostering a conscious approach to environmental stewardship. This research underscores the critical role of Islamic teachings in safeguarding the natural environment, reaffirming humanity's divine responsibility to serve as stewards of the Earth.
On discrete orthogonal U-Bernoulli Korobov-type polynomials
Authors: Urieles Alejandro , Ramirez William , Cesarano Clemente
Published: December 2024

The primary objective of this paper is to introduce and examine the new class of discrete orthogonal polynomials called $U$-Bernoulli Korobov-type polynomials. Furthermore, we derive essential recurrence relations and explicit representations for this polynomial class. Most of the results are proven through the utilization of generating function methods. Lastly, we place particular emphasis on investigating the orthogonality relation associated with these polynomials.
The Jinc- function: a note on the relevant generalizations and applications
Authors: Curcio Alessandro , Dattoli G. , Di Palma Emanuele
Published: December 2024

Jinc and sinc-functions are well known special functions with important applications in Spectral theory, Fourier Optics and diffraction problems from circular apertures. The first are less widespread known than the latter and should be more properly framed within the context of special functions. In this article we present a unified point of view to the relevant generalizations, propose generalized forms and touch on application perspectives.
Approximation of the Hilbert transform on $(0,+\infty)$ by using discrete de la Vall\'ee Poussin filtered polynomials
Authors: Occorsio Donatella
Published: December 2024

In the present paper, is proposed a method to approximate the Hilbert transform of a given function $f$ on $(0,\infty)$ employing truncated de la Vallée discrete polynomials recently studied in [25]. The method generalizes and improves in some sense a method based on truncated Lagrange interpolating polynomials introduced in [24], since is faster convergent and simpler to apply. Moreover, the additional parameter defining de la Vallée polynomials helps to attain better pointwise approximations. Stability and convergence are studied in weighted uniform spaces and some numerical tests are provided to asses the performance of the procedure.
Comparison of the Efficacy of Different Methods of Treatment of Severe Local Radiation Injuries in an Experiment
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Deshevoi Yu.B. , Lebedev V.G. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Nasonova T.A. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Dobrynina O.A. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Umnikov A.S. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Astrelina T.A. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Samoylov A.S. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Soloviev V.Yu. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: December 2024

Purpose: To compare the effectiveness of different methods of treating severe local radiation injuries (LRI) under the same experimental conditions.
Material and methods: Male rats of the Wistar-Kyoto inbred line were locally irradiated in the ilioplumbar region of the back using an X-ray unit LNK-268 at a dose of 110 Gy (tube voltage 30 kV, current 6.1 mA, Al filter 0.1 mm thick), at a dose rate of 20.0 Gy/min. The area of the irradiation field was 8.2 cm2. Such radiation exposure led to the occurrence of severe LRI in rats with long-term non-healing skin ulcers, without critical radiation exposure to the underlying tissues.
For the treatment of severe LRI, surgical methods, cell or drug therapy were used, which were used separately from each other. Treatment began on the 28th day after local irradiation, that is, during the period when the radiation ulcer had already formed and regenerative processes began to activate in the affected area. Various surgical approaches were used: from complete excision of the radiation ulcer to removal of various volumes of necrotic tissue within the radiation ulcer. Cell therapy consisted of transplantation of syngeneous cells of the stromal vascular fraction of adipose tissue or cultured syngeneous multipotent mesenchymal stromal cells. The cells were injected subcutaneously around the radiation ulcer twice at 1-week intervals. For drug therapy of severe local radiation injuries, we used a veterinary complex antibiotic ‒ levotetrasulfin forte, as well as drugs that affect the microcirculation and trophism of irradiated tissues – pentoxifylline and detralex. The drugs were used once a day from the 28th to the 49th day after irradiation.
Results and coclusion: The use of surgical methods, cell or drug therapy facilitated the course of the pathological process and accelerated the healing of radiation ulcers. However, different treatments for severe LRI have had different efficacy. In terms of the rate and quality of healing of severe local radiation injuries, drug therapy is less effective than cellular therapy, and cell therapy is less effective than complete surgical excision of radiation ulcers.
Analysis of the Incidence of Solid Malignant Neoplasms in the Urals Cohort of Exposed Population Offspring
Authors:   Ural Research Center for Radiation Medicine, Chelyabinsk, Russia, Zavyalov D.A. , Krestinina L.Yu. ,   Ural Research Center for Radiation Medicine, Chelyabinsk, Russia
Published: December 2024

Purpose: The study of regularities in the incidence of solid cancer in the Urals Cohort of the Exposed Population Offspring over a 65-year follow-up period.

Material and methods: The study was conducted by cohort method. The cohort under study is the Urals Cohort of the Exposed Population Offspring. It includes offspring of the population exposed in the period from 1950 to 1960 in the Southern Urals (on the Techa River and at the East Urals radioactive trace). The catchment area includes 5 districts of the Chelyabinsk region, as well as the city of Chelyabinsk and the city of Ozyorsk. The follow-up period was 65 years, from 01.01.1956 to 31.12.2020, the number of the analytical cohort for 2024 is 24952 people, the number of person-years under follow-up is 850698. Calculation of cases, incidence rates, person-years and statistical processing of data were performed by standard methods using the DATAB program module of the Epicure statistical package.

Results: During the 65-year period, 569 cases of solid cancers were registered in the catchment area. In women the most frequent cases were neoplasms of female reproductive organs, breast, thyroid gland, whole intestine and upper digestive tract organs; in men - respiratory organs, upper digestive tract and whole intestine. A significant increase in the incidence rates was found in women in age groups older than 20 years and in men in groups older than 30 years. Statistically significant sex-depended differences were observed only in the age groups between 30 and 50 years. No significant differences in the incidence rates among offspring of different ethnic groups were found. An assessment of incidence rates by calendar periods was carried out: in women, a significant increase in incidence rates began in 1990, in men in 2005 and significant differences by sex were observed only in the period from 2005 to 2020.

Conclusion: The study revealed patterns in the incidence of solid malignant neoplasms within the offspring cohort by sex, age and depending on the calendar period. These patterns will be taken into account in future studies when assessing the dependence of the incidence of solid malignant neoplasms in offspring on parental gonadal dose.
Combined Method for Treating Orophynary Cancer
Authors:   Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia, Udalov Yu.D. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Vorobyov A.A. ,   Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia, Nezvetsky A.V. ,   Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia, Kiselev V.A. ,   Federal Scientific Clinical Center for Medical Radiology and Oncology, Dimitrovgrad, Russia
Published: December 2024

Purpose: To demonstrate the possibility of a combined approach in the treatment of a patient with locally advanced squamous cell carcinoma of the nasopharynx, complicated by massive erosive bleeding using endovascular embolization, proton therapy and targeted therapy.

Material and methods: The Federal Scientific Research Center for Reconstruction and Research has developed a method of a combined approach to the treatment of patients with malignant neoplasms of the nasopharynx, during which endovascular embolization and proton beam therapy in combination with targeted therapy are consistently used.

Results: A set of sequential treatment procedures and drug administration allowed us to eliminate life-threatening bleeding, normalize the patient’s general condition, conduct a course of proton radiation therapy for a patient with locally advanced squamous cell carcinoma of the nasopharynx, complicated by massive bleeding, and achieve stable local control over the process.

Conclusion: The use of the described tactics in the treatment of tumors of the nasopharynx and oral cavity allows in a short period to move from urgent endovascular occlusion of bleeding vessels to the stages of special antitumor treatment, providing a combined approach to the treatment of head and neck tumors.
Stochastic Model of the Processe of the Spread of Platinum Drugs in Tumor Tissues
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Ginevsky D.A. , Izhevskij P.V. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Laschenova T.N. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: December 2024

Purpose: The study of the kinetics of the spatio-temporal distribution of cisplatin, as an agent capable of increasing the effectiveness of chemo-radiation therapy of solid tumors.

Material and methods: The material was the data of literature on the results of experiments of various groups of authors who studied the content of platinum in tissues on biopsy materials. The method of simulation mathematical modeling (in silico) is used, based on the biological patterns of tumor growth, morphofunctional changes in the structure of tumor cells and tissues. Model is based on reaction-diffusion equation system, coefficients of which are random functions of space and time. The model takes into account the sequence of processes from intravenous administration of cisplatin and its spatial distribution in various tissues, until the excretion of its addicts from the cell.

Results: The heterogeneity of the distribution of the concentration of platinum atoms in the tumor is shown. Perhaps this is due to the varying degree of vascularization of tissues, the rate of metabolism of the tumor occurring in the outer layer and in its hypoxic core. These processes lead to significant errors when evaluating the biopsy data obtained in the experiments and the analysis of platinum content in the biopsy.

Conclusions: The calculation assessments of the distribution of platinum atoms in the tumor are consistent with the literature on the concentration of cisplatin in biopsy samples for carcinoma. The results of the calculations on the described model are fair, taking into account the morphological type, the size of the tumor and the plan of the administration of the drug. For other conditions (cancer types, treatment regimens, etc.), new calculations are necessary. To increase the efficiency of combined chemo-radiation therapy, cisplatin should be introduced at least 72 hours before the start of radiation therapy.
Altered amino and fatty acids metabolism in Sudanese prostate cancer patients: insights from metabolic analysis
Authors: Ahmed Dalia , Ebtesam A. Abdel-Shafy  , Elsadig Ahmed Adam Mohammed  , Husam Elden Alnour Bakhet Alnour  , Amar Mohamed Ismail  , Cacciatore Stefano , Luiz Fernando Zerbini
Published: December 2024

Introduction: Prostate cancer (PCa) management presents a multifaceted clinical challenge, intricately linking oncological considerations with cardiovascular health. Despite the recognized importance of lipid metabolism and hypertension in this interwoven relationship, their involvement in PCa development remains partially understood. This study aimed to explore variations in plasma metabolome among Sudanese PCa patients and their associated comorbidities.
Methods: Plasma samples were collected from 50 patients across four hospitals in Sudan and profiled by nuclear magnetic resonance (NMR) spectroscopy. One-dimensional proton NMR spectra were acquired for each sample using standard nuclear Overhauser effect spectroscopy pulse sequence presat on a 500 MHz Bruker Avance III HD NMR spectrometer. Metabolite concentrations were quantified using R scripts developed in-house. Univariate and multivariate analyses were generated in the R software.
Results: Patients were categorized into four distinct metabotypes based on their metabolic profiles, and statistical analyses were conducted to evaluate the significance of observed differences. Our findings revealed high levels of fatty acids, phospholipids, cholesterol, valine, leucine, and isoleucine associated with non-hypertensive patients. In contrast, hypertensive patients were associated with high GlycA and GlycB levels and altered amino acid metabolism.
Conclusion: These findings underscore the intricate interplay between metabolic dysregulation and hypertension in PCa patients. Further research is warranted to elucidate the precise molecular pathways underlying lipid metabolism in PCa and to explore the therapeutic potential of targeting these pathways. In conclusion, our study contributes to a deeper understanding of the metabolic landscape of PCa in Sudanese patients, emphasizing the importance of personalized approaches in cancer management.
Analisis Pengelolaan Anggaran Pendapatan Dan Belanja Desa (APBDes) Didesa Gaya Jaya Kecamatan Lawe Sigala-Gala
Authors: Marpaung Rifka Sepliana , Hutapea Herti Diana , Saribu Ardin Dolok
Published: December 2024

This study aims to determine the process of planning, implementing, administering, reporting and accountability of the Village Revenue and Expenditure Budget in Gaya jaya Village, Lawe sigala-gala District in accordance with the Regulation of the Minister of Home Affairs Numbers 20 of 2018 concerning village financial management. This study is a type of qualitative descriptive research using primary data and secondary data, where primay data is in the form of direct observation result in the form of interviews regarding the planning, implementation, administration, reporting and accountability of the Village Budget of Gaya jaya Village, Lawe sigala-gala District in 2023 while secondary data uses the financial report of the Village Budget of Gaya jaya Village, Lawe sigala-gala District. In this study, data analysis techniques were used by means of data consistency and data presentation and drawing conclusions. The result of this study indicate that the management of the Village Budget of Gaya jaya Village, Lawe sigala-gala District, including planning, implementation, reporting, and accountability, has been carried out in accordance with the Regulation of the Minister of Home Affairs Number 20 of 2018. However, the administration section is not in accordance with the Regulation of the Minister of Home Affairs Number 20 of 2018, so in this case it must remain or be given guidance and direction from the Gaya jaya Village government.