bluuebunny/crossref_metadata_2025 huggingface dataset:
“Be honest and gain trust”: a population health study to understand the factors associated with building trust in local government related to COVID-19 and vaccination in three historically disinvested neighborhoods in New York City
Authors: Shiman Lauren J. , Diallo Fatoumata , Nieves Christina I. , Brooks Brandon , Dannefer Rachel , Dorvil Sheena , Lejano Maria , Pierre Jennifer
Published: October 2023

Background

Distrust in government among people of color is a response to generations of systemic racism that have produced preventable health inequities. Higher levels of trust in government are associated with better adherence to government guidelines and policies during emergencies, but factors associated with trust and potential actions to increase trust in local government are not well understood.

Methods

The COVID-19 Community Recovery study sampled participants from the New York City (NYC) Department of Health and Mental Hygiene’s NYC Health Panel, a probability-based survey panel who complete health surveys periodically. Participants who lived in one of three historically disinvested communities in NYC where the NYC Department of Health and Mental Hygiene has dedicated resources to reduce health inequities were included. The cross-sectional survey was fielded from September 30 to November 4, 2021 and could be self-administered online or conducted via CATI (Computer Assisted Telephone Interviewing) in English, Spanish, and Simplified Chinese (Mandarin and Cantonese by phone). Demographic data were summarized by descriptive statistics. Crude and adjusted logistic regression analyses were used to assess factors predictive of trust in local government as a source of information about COVID-19 vaccines. Open-ended responses about strengthening residents’ trust in local government were coded using an iteratively generated codebook.

Results

In total, 46% of respondents indicated NYC local government was a trusted source of information about COVID-19 vaccines, relatively high compared to other sources. In bivariate analyses, race/ethnicity, age group, educational attainment, length of time living in NYC, and household income were significantly associated with identifying NYC government as a trusted source of information about COVID-19 vaccines. In multivariable logistic regression, no variables remained significant predictors of selecting local government as a trusted source of information. Key recommendations for local government agencies to build residents’ trust include communicating clearly and honestly, addressing socioeconomic challenges, and enhancing public COVID-19 protection measures.

Conclusion

Study findings demonstrate that nearly half of residents in three historically divested NYC communities consider local government to be a trusted source of information about COVID-19 vaccines. Strategies to increase trust in local government can help reduce community transmission of COVID-19 and protect public health.
Expression profiles of glucocorticoid-inducible proteins in human papilloma virus-related oropharyngeal squamous cell carcinoma
Authors: Mozaffari Mahmood S. , Abdelsayed Rafik , Emami Sahar , Kavuri Sravan
Published: October 2023

Introduction

Human papillomavirus virus-related oropharyngeal squamous cell carcinoma (HPV-OPSCC) comprises a significant portion of head and neck cancers. Several glucocorticoid-inducible proteins play important roles in pathogenesis of some cancers but their status and roles in HPV-OPSCC remain elusive; these include the glucocorticoid-induced leucine zipper (GILZ), Annexin-A1 and serum glucocorticoid-regulated kinase-1 (SGK-1).

Methods

We determined expression profiles of these proteins, using immunohistochemistry, in archived biopsy samples of patients diagnosed with HPV-OPSCC; samples of non-cancer oral lesions (e.g., hyperkeratosis) were used as controls.

Results

GILZ staining was primarily confined to nuclei of all tissues but, in HPV-OPSCC specimens, neoplastic cells exhibiting mitosis displayed prominent cytoplasmic GILZ expression. On the other hand, nuclear, cytoplasmic and membranous Annexin-A1 staining was observed in suprabasal cell layers of control specimens. A noted feature of the HPV-OPSCC specimens was few clusters of matured and differentiated nonbasaloid cells that showed prominent nuclear and cytoplasmic Annexin-A1 staining while the remainder of the tumor mass was devoid of staining. Cytoplasmic and nuclear staining for SGK-1 was prominent for control than PV-OPSCC specimens while staining for phosphorylated SGK-1 (pSGK-1; active) was prominent for cell membrane and cytoplasm of control specimens but HPV-OPSCC specimens showed mild and patchy nuclear and cytoplasmic staining. Semi-quantitative analysis of GILZ immunostaining indicated increased staining area but similar normalized staining for HPV-OPSCC compared to control specimens. By contrast, staining area and normalized staining were reduced for other proteins in HPV-OPSCC than control specimens.

Discussion

Our collective observations suggest differential cellular localization and expression of glucocorticoid-inducible proteins in HPV-OPSCC suggestive of different functional roles in pathogenesis of this condition.
Treatment-seeking behaviour among infertile tribal women of Palghar district in India
Authors: Jadhav Arvind Santu , Govil Dipti
Published: October 2023

Background

The tribal culture views health care practices differently from the mainstream. Infertile tribal women practice treatment-seeking behaviour that reflects the community's cultural access to and availability of treatment as well as customs to meet their health care needs. In the environment of rising awareness of infertility and numerous treatment options, this study aims to highlight the infertility treatment-seeking behaviour of tribal communities.

Data and methods

The study employed a mix methods approach to collect data from 153 tribal couples suffering with infertility (interview schedule) and the community (in-depth interviews—14 and focus group discussions—12). The data was analyzed using Stata 13.0, and NVivo 10. Results of the quantitative data were triangulated with qualitative data for writing.

Results

Many treatment options were available for infertility in the community. Generally, traditional healers (98.7%) were preferred over modern healthcare practitioners (35%). Community members usually guided infertile couples for choosing providers. Treatment practices were very different among primary infertile women than sub-fertile. Women frequently discontinued treatment and switched between providers because of unaffordability, poor connectivity, distance, travel time, time constraints, and non-supportive circumstances. The couples were advised to consume herbs, and eat or avoid certain food items, were given massage, burns on the abdomen (dagani), removed black blood (phasani) and other various rituals to appease spirits, get rid of ghosts while offering animal sacrifice, and conducting shidwa ritual. The mean expenditure on treatment was INR 18,374. If treatment did not yield any result, couple resorted to add another wife, divorce, accept childlessness and foster a child.

Conclusion

Local authorities should strive to work towards the socio-economic development of the tribal communities and provide good healthcare services at their doorstep. The infertility problem needs to be understood in the context of poverty, tribal beliefs, and unequal access to healthcare resources.
Study of the effect of the compaction level on the hydrodynamic properties of loamy sand soil in an agricultural context
Authors: Mbarki Yasmin , Gumiere Silvio José , Celicourt Paul , Brédy Jhemson
Published: October 2023

Agricultural soil compaction adversely affects crop water use and yield performance and should be avoided or remediated through appropriate soil management strategies. The investigation of the impact of different levels of soil compaction on its hydrodynamic properties remains a crucial step in improving water use and crop yields. We examined five compaction levels of silty sand soil sampled from a potato field in the agricultural regions of northern Quebec (Canada). Soil hydraulic characteristics (saturated and unsaturated hydraulic conductivity, soil water retention capacity) were measured using the constant head method, the HYPROP device, and a WP4C dew point potentiometer. The sixteen hydraulic models integrated into the HYPROP software were fitted to the soil water retention curve (SWRC) data for the studied compaction levels. Statistical parameters such as the mean bias error, mean absolute error, correlation coefficient, and root mean square error were used to measure the performance of the models. The results show that saturated and unsaturated conductivity decreases with increasing soil compaction. The lowest saturated hydraulic conductivity (Ks) value is observed for the highest level of soil compaction, reflecting a solid medium with less pore space and connectivity. Among the hydraulic models, the Peters-Durner-Iden (PDI) variant of van Genuchten's unconstrained bimodal model (VGm-b-PDI) outperformed all other models for SWRC simulation of different soil compaction levels and was, accordingly, selected as the optimal model. This model was implemented in HYDRUS-1D to estimate the amount of irrigation for different compaction levels. We simulated irrigation scenarios with the dual-porosity model. The results indicated that soil compaction can strongly influence soil hydraulic properties and water differently. However, the amount of irrigation for the potato crop was optimal at a moderate level of soil compaction. Overall, combined HYPROP and HYDRUS 1D can provide helpful information on the soil hydraulics properties dynamics and a rigorous simulation for irrigation planning and management in potato fields.
How Video Games Change The Brain
Authors: Parong Jocelyn , Green C. Shawn
Published: October 2023

The brain controls how we see, hear, think, learn, and interact with the world. Importantly, the brain is not set in stone. It can be changed over time by the things we do. One of those things is playing video games! Playing video games can lead to a number of changes in the brain, some of which allow us to see, hear, think, and learn better. Crucially though, not all video games are equal. Just like eating different kinds of foods will affect the body in different ways, playing different types of video games will affect the brain in different ways. In this article, we will describe how scientists can measure changes in the brain and how playing video games can change the brain.
Social entrepreneurship in sport: a peripheral country perspective
Authors: Kamyuka Denise , Misener Laura , Tippett Marisa
Published: October 2023

For the past decade, scholars have been working towards developing a robust theory of social entrepreneurship in sport (SES). However, SES theory remains void of peripheral country perspectives and thus perpetuates the Eurocentric views of entrepreneurship. This paper used a decolonial feminist lens and Whittemore and Knafl’s methodology to conduct an integrated review of SES literature written in or about a peripheral country context. The review examined how scholarship from and about this context had considered geographical and culturally specific perspectives in the development of SES theory. A total of n = 1971 papers were retrieved, with only n = 12 providing relevant peripheral country context. This scarcity of literature indicates that the current theory of SES lacks peripheral country perspectives. Many papers in this review (n = 5) are written by authors in or from a peripheral country. Their contributions to SES literature revealed the decolonial feminist approaches that centralize alternative perspectives and added plurality to the definition of SES. The findings revealed the nuanced theoretical approaches to SES and highlighted the gaps in this context. The review shows how, despite the rise in social enterprises that focus on gender equity and the economic inclusion of women, gendered studies were still very scarce.
The hidden end of the value chain: potentials of integrating gender, households, and consumption into agrifood chain analysis
Authors: Brückner Meike , Sardadvar Karin
Published: October 2023

The aim of this perspective paper is to reinforce the analysis of gender relations in agrifood chain research and integrate the household and the work and consumption taking place there. In the value chain discourse, approaches that integrate households and consumption as an analytical dimension exist, but the last stage often remains hidden. To take a holistic view on value chains integrating the hidden end, we apply feminist economic perspectives and gender analysis to agrifood chains. This paper builds on our own research while integrating it with other scholars’ empirical work and the theoretical literature concerning gender and value chains. Drawing on empirical examples from both the Global North and South (e.g., on the meat, tomato, seafood, and African Indigenous Vegetables chains), we illustrate the importance of households and consumption to value chain analysis with three examples: Firstly, we demonstrate how commercialization in agrifood chains impacts consumption practices and the food-related care work of women; secondly, we discuss how market-oriented reforms to production in a globalized economy restrict control and access to food for producers; and thirdly, we illustrate that consumer appetite influences working conditions in food production and policies. The examples underscore the fact that households and consumption are not isolated components, but are embedded in a complex agrifood system. In the final part of the paper, we propose an agenda for making this hidden end of the value chain and its links to gender, the household, and consumption more visible.
ThIRST: Targeted IRrigation Support Tool for sustainable coffee production
Authors: Nguyen Kien Tri , Craparo Alessandro , Nguyen Phuong Minh , Turreira-García Nerea , Talsma Tiffany , Deniau Aline , Bossolasco Laurent , Le Trung Dang , Bosselmann Aske Skovmand
Published: October 2023

The Central Highlands of Vietnam is an important Robusta coffee growing region. However, the region is facing climate change impacts from rising temperatures and irregular rainfall, while Vietnamese coffee farmers predominantly rely on irrigation from heavily depleted aquifers. To continue productive and sustainable growth, this system requires an innovative approach to meet this hydrological challenge. Here we propose a user-friendly tool, which aims to support coffee farmers’ irrigation decisions, through the Targeted Irrigation Support Tool or ThIRST. ThIRST combines seasonal forecasts, on-farm metrics, and farmer’s expertise. The research comprises baseline (n = 400) and endline (n = 237) surveys of coffee farmers in Đắk Lắk and Lâm Đồng Provinces. Through the surveys, farmers’ irrigation needs and the applicability of the tool are evaluated. Despite low smartphone usage for farming advisory, the results show the tool allows coffee farmers to continually achieve water-use efficiency and adapt to climate variability. Involving farmers in the design, production and evaluation of climate services can improve the trust and uptake of agro-advisories and the way this information is communicated.
Therapeutic evaluation and analysis of complications of ethanol sclerotherapy for intramuscular vascular malformations: a single-center retrospective study
Authors: Jin Cai-Jun , Wang Qian , Wang Min , Chen Yong , Yuan Si-Ming
Published: October 2023

Background

Intramuscular venous malformations (IMVMs) can cause pain and contracture deformity, leading to dysfunction of limbs. Ethanol sclerotherapy is one of the main treatments for IMVMs. This study aims to evaluate the efficacy and the complications associated with intravascular ethanol sclerotherapy for IMVMs and to provide a comprehensive summary of clinical experiences for future reference.

Methods

A retrospective analysis was conducted on a cohort of 118 patients diagnosed with IMVMs who were treated with ethanol sclerotherapy in our center between 2006 and 2021. The plastic surgeons utilized a standardized collection pro forma to record the clinical data. Furthermore, a follow-up period ranging from 6 months to 5 years was implemented to assess the relief of symptoms, the change of lesion size, and the recovery of functional outcomes. In addition, an analysis of long-term complications was conducted.

Results

The clinical symptoms of the patients in this group included pain, swelling, and limited movement. On average, 5.61 mL (range 2–14 mL) of ethanol was used during the sclerotherapy procedure. The intraoperative and early postoperative complications were successfully relieved by means of timely intervention, as observed during the follow-up period. Based on the MRI results, the sizes of the lesions in 19% of the cases were significantly decreased, while a slight decrease was observed in 39% of the cases. During the follow-up period, it was found that only eight out of the 118 patients included in this study experienced long-term complications related to sclerotherapy.

Conclusions

Although ethanol sclerotherapy has proven to be an effective first-line treatment for IMVMs, it is associated with a variety of adverse reactions and short- and long-term complications. Surgeons are required to perform operations prudently and provide timely medical intervention for postoperative complications.
Prospective measurement of outcomes and complications of tibial tuberosity advancement using novel mini plates in small breed dogs
Authors: Miller Leah , Maritato Karl C. , Kennedy Shawn C.
Published: October 2023

Cranial cruciate ligament (CrCL) disease is a common orthopedic disease in canine patients. Tibial osteotomy procedures for the treatment of cranial cruciate ligament disease in small breed dogs (<15 kg) have previously been limited. A total of 22 client-owned dogs, 26 stifles, with cranial cruciate ligament disease were treated with novel mini-tibial tuberosity advancement plates. The most common intraoperative complications included the need for plate-cage overlap in 7 stifles (26.92%) and screw head fracture in 1 (3.85%). Post-operative complications included tibial tuberosity fracture (3.85%), post-operative medial patella luxation (7.69%), and persistent lameness (7.69%). Of the 26 stifles evaluated in the medium term (>6–12 months) post-operatively, 92.3% had no lameness, with the remaining 7.7% having Grade 1 lameness. A good to excellent clinical outcome was noted in all 26 stifles that underwent TTA with novel mini plates.
The Effect of Family Wealth on Physical Function Among Older Adults in Mpumalanga, South Africa: A Causal Network Analysis
Authors: Makofane Keletso , Berkman Lisa F. , Bassett Mary T. , Tchetgen Tchetgen Eric J.
Published: October 2023

Objectives: The aging of the South African population could have profound implications for the independence and overall quality of life of older adults as life expectancy increases. While there is evidence that lifetime socio-economic status shapes risks for later function and disability, it is unclear whether, and how, the wealth of family members shapes these outcomes. We investigated the relationship between outcomes activities of daily living (ADL), grip strength, and gait speed, and the household wealth of non-coresident family members.

Methods: Using data from Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) and the Agincourt Health and Demographic Surveillance System (AHDSS), we examined the relationship between physical function and household and family wealth in the 13 preceding years. HAALSI is a cohort of 5,059 adults who were 40 years or older at baseline in 2014. Using auto-g-computation—a recently proposed statistical approach to quantify causal effects in the context of a network of interconnected units—we estimated the effect of own and family wealth on the outcomes of interest.

Results: We found no evidence of effects of family wealth on physical function and disability.

Conclusion: Further research is needed to assess the effect of family wealth in early life on physical function and disability outcomes.
Two-Degrees-of-Freedom PID Control with Kalman Filter for Engraving Machine System
Authors: Dong Shijian , Hao Leilei , Shao Yiqin , Liu Jun , Han Lixin
Published: October 2023

For an engraving machine system with input dynamic disturbance and output random measurement noise, a two-degrees-of-freedom proportional integral derivative (2-DOF PID) control method based on the Kalman filter is firstly proposed in this paper, which can effectively reject the input disturbance and ensure the set point tracking performance of the controller. The 2-DOF controller consists of a disturbance rejection controller and a set point tracking controller. The disturbance rejection controller is composed of a PID controller based on a disturbance observer and expectation model. The parameters of the set point tracking controller are tuned using a differential evolution algorithm (DE), and the cumulative absolute error value (IAE) is used as the fitness function of the DE algorithm, which can improve the rationality of intelligent parameter tuning. In addition, the Kalman filter is also applied to deal with the output noise to suppress the influence of the output measurement uncertainty. Finally, compared with existing algorithms, the feasibility and superiority of the proposed algorithm are verified using numerical simulation and an experimental test.
Evaluation of the Effects of Nano-SiO2 Microemulsion on Decompression and Augmented Injection in the Eunan Tight Reservoir
Authors: Wu Ke , Xu Mingbiao , Wen Shoucheng , Deng Xuefeng
Published: October 2023

The residual oil saturation of the matrix near the well zone of a tight reservoir is high due to the tight reservoir’s complex conditions, such as the small pore throat radius and low permeability of the matrix and the development of microfractures, which can result in serious water channeling, even after long-term water injection development. The aim of this paper is to improve the effects of depressurization and augmented injection for tight reservoir waterflooding development by reducing the tight matrix’s residual oil saturation, increasing and maintaining its water phase permeability near the well zone using a nano-SiO2 microemulsion system with a small particle size and high interfacial activity. Therefore, four nano-microemulsion systems were evaluated and screened for their temperature resistance, salt resistance, interfacial tension, solubilization, and dilution resistance. A microemulsion system of 13% A + 4% B + 4% C + 4% n-butanol + 6% oil phase + 69% NaCl solution (10%) + 1% OP-5 + 0.5% anti-temperature agent + 0.3% nanosilica material was preferred. According to the core displacement experiment, the depressurization rate can reach 28~60% when the injection concentration of the system is 1~10% and the injection volume is 2~5 PV. The results of the on-site test show that the water injection pressure dropped to 17.5 MPa, which was lower than the reservoir fracture re-opening pressure. The pressure reduction rate was approximately 20%. The validity period of the depressurization and augmented injection has reached 23 months to date.
pH Regulator on Digital Microfluidics with Pico-Dosing Technique
Authors: Li Haoran , Peng Tao , Zhong Yunlong , Liu Meiqing , Mak Pui-In , Martins Rui P. , Wang Ping , Jia Yanwei
Published: October 2023

Real-time pH control on-chip is a crucial factor for cell-based experiments in microfluidics, yet difficult to realize. In this paper, we present a flexible pH regulator on a digital microfluidic (DMF) platform. The pico-dosing technology, which can generate and transfer satellite droplets, is presented to deliver alkali/acid into the sample solution to change the pH value of the sample. An image analysis method based on ImageJ is developed to calculate the delivered volume and an on-chip colorimetric method is proposed to determine the pH value of the sample solution containing the acid-base indicator. The calculated pH values show consistency with the measured ones. Our approach makes the real-time pH control of the on-chip biological experiment more easy to control and flexible.
Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
Authors: Larrea Ane , Elexpe Ane , Díez-Martín Eguzkiñe , Torrecilla María , Astigarraga Egoitz , Barreda-Gómez Gabriel
Published: October 2023

Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules or specific markers. In parallel, new therapeutic targets are being investigated via the use of bionanomaterials and electrostimulation to modulate the neuroinflammatory response. These novel diagnostic and therapeutic strategies have the potential to facilitate the development of anticipatory patterns and deliver the most beneficial treatment to improve patients’ quality of life and directly impact their motor skills. However, important challenges remain to be solved. Hence, the goal of this study was to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, with a particular focus on novel methods and potential biomarkers to aid clinicians in diagnosis, treatment, and therapy. A specific analysis of the strengths, weaknesses, threats, and opportunities was conducted, highlighting the key challenges to be faced in the coming years.
Pneumonectomy for Primary Lung Tumors and Pulmonary Metastases: A Comprehensive Study of Postoperative Morbidity, Early Mortality, and Preoperative Clinical Prognostic Factors
Authors: Grapatsas Konstantinos , Menghesha Hruy , Dörr Fabian , Baldes Natalie , Schuler Martin , Stuschke Martin , Darwiche Kaid , Taube Christian , Bölükbas Servet
Published: October 2023

Background: Pneumonectomy is a major surgical resection that still remains a high-risk operation. The current study aims to investigate perioperative risk factors for postoperative morbidity and early mortality after pneumonectomy for thoracic malignancies. Methods: We retrospectively analyzed all patients who underwent pneumonectomy for thoracic malignancies at our institution between 2014 and 2022. Complications were assessed up to 30 days after the operation. Mortality for any reason was recorded after 30 days and 90 days. Results: A total of 145 out of 169 patients undergoing pneumonectomy were included in this study. The postoperative 30-day complication rate was 41.4%. The 30-day-mortality was 8.3%, and 90-day-mortality 17.2%. The presence of cardiovascular comorbidities was a risk factor for major cardiopulmonary complications (54.2% vs. 13.2%, p < 0.01). Postoperative bronchus stump insufficiency (OR: 11.883, 95% CI: 1.288–109.591, p = 0.029) and American Society of Anesthesiologists (ASA) score 4 (OR: 3.023, 95% CI: 1.028–8.892, p = 0.044) were independent factors for early mortality. Conclusion: Pneumonectomy for thoracic malignancies remains a high-risk major lung resection with significant postoperative morbidity and mortality. Attention should be paid to the preoperative selection of patients.
UAV-Based Subsurface Data Collection Using a Low-Tech Ground-Truthing Payload System Enhances Shallow-Water Monitoring
Authors: Thomasberger Aris , Nielsen Mette Møller
Published: October 2023

Unoccupied Aerial Vehicles (UAVs) are a widely applied tool used to monitor shallow water habitats. A recurrent issue when conducting UAV-based monitoring of submerged habitats is the collection of ground-truthing data needed as training and validation samples for the classification of aerial imagery, as well as for the identification of ecologically relevant information such as the vegetation depth limit. To address these limitations, a payload system was developed to collect subsurface data in the form of videos and depth measurements. In a 7 ha large study area, 136 point observations were collected and subsequently used to (1) train and validate the object-based classification of aerial imagery, (2) create a class distribution map based on the interpolation of point observations, (3) identify additional ecological relevant information and (4) create a bathymetry map of the study area. The classification based on ground-truthing samples achieved an overall accuracy of 98% and agreed to 84% with the class distribution map based on point interpolation. Additional ecologically relevant information, such as the vegetation depth limit, was recorded, and a bathymetry map of the study site was created. The findings of this study show that UAV-based shallow-water monitoring can be improved by applying the proposed tool.
Finding the Age and Education Level of Bulgarian-Speaking Internet Users Using Keystroke Dynamics
Authors: Grunova Denitsa , Tsimperidis Ioannis
Published: October 2023

The rapid development of information and communication technologies and the widespread use of the Internet has made it imperative to implement advanced user authentication methods based on the analysis of behavioural biometric data. In contrast to traditional authentication techniques, such as the simple use of passwords, these new methods face the challenge of authenticating users at more complex levels, even after the initial verification. This is particularly important as it helps to address risks such as the possibility of forgery and the disclosure of personal information to unauthorised individuals. In this study, the use of keystroke dynamics has been chosen as a biometric, which is the way a user uses the keyboard. Specifically, a number of Bulgarian-speaking users have been recorded during their daily keyboard use, and then a system has been implemented which, with the help of machine learning models, recognises certain acquired or intrinsic characteristics in order to reveal part of their identity. The results show that users can be categorised using keystroke dynamics, in terms of the age group they belong to and in terms of their educational level, with high accuracy rates, which is a strong indication for the creation of applications to enhance user security and facilitate their use of Internet services.
High-Order Chebyshev Pseudospectral Tempered Fractional Operational Matrices and Tempered Fractional Differential Problems
Authors: El-Abed Amel , Dahy Sayed A. , El-Hawary H. M. , Aboelenen Tarek , Fahim Alaa
Published: October 2023

This paper focuses on presenting an accurate, stable, efficient, and fast pseudospectral method to solve tempered fractional differential equations (TFDEs) in both spatial and temporal dimensions. We employ the Chebyshev interpolating polynomial for g at Gauss–Lobatto (GL) points in the range [−1,1] and any identically shifted range. The proposed method carries with it a recast of the TFDE into integration formulas to take advantage of the adaptation of the integral operators, hence avoiding the ill-conditioning and reduction in the convergence rate of integer differential operators. Via various tempered fractional differential applications, the present technique shows many advantages; for instance, spectral accuracy, a much higher rate of running, fewer computational hurdles and programming, calculating the tempered-derivative/integral of fractional order, and its spectral accuracy in comparison with other competitive numerical schemes. The study includes stability and convergence analyses and the elapsed times taken to construct the collocation matrices and obtain the numerical solutions, as well as a numerical examination of the produced condition number κ(A) of the resulting linear systems. The accuracy and efficiency of the proposed method are studied from the standpoint of the L2 and L∞-norms error and the fast rate of spectral convergence.
The Utilization of 15-Minute Multidisciplinary Rounds to Reduce Length of Stay in Patients under Observation Status
Authors: Patel Swapnil V. , Alshami Abbas , Douedi Steven , Udongwo Ndausung , Hossain Mohammad , Tarina Dana , Walch Brian , Carpenter Kim , Kountz David , Buccellato Vito , Sable Kenneth , Frank Elliot , Asif Arif
Published: October 2023

With the recent change to value-based care, institutions have struggled with the appropriate management of patients under observation. Observation status can have a huge impact on hospital and patient expenses. Institutions have implemented specialized observation units to provide better care for these patients. Starting in January 2020, coinciding with the initiation of daily multidisciplinary rounds, our study focused on patients aged 18 and older admitted to our hospital under observation status. Efforts were built upon prior initiatives at Jersey Shore University Medical Center (JSUMC) to optimize patient care and length of stay (LOS) reduction. The central intervention revolved around the establishment of daily “Observation Huddles”—succinct rounds led by hospital leaders to harmonize care for patients under observation. The primary aim was to assess the impact of daily multidisciplinary rounds (MDR) on LOS, while our secondary aim involved identifying specific barriers and interventions that contributed to the observed reduction. Our study revealed a 9-h reduction in observation time, resulting in approximately USD 187.50 saved per patient. When accounting for the period spanning 2020 to 2022, potential savings totaled USD 828,187.50 in 2020, USD 1,046,062.50 in 2021, and USD 1,243,562.50 in 2022. MDR for observation patients led to a reduction in LOS from 29 h to 20 h (p < 0.001).
Virome Analysis of Aconitum carmichaelii Reveals Infection by Eleven Viruses, including Two Potentially New Species
Authors: Yang Jie , Lan Ping-Xiu , Wang Yun , Li Jin-Ming , Li Ruhui , Wylie Steve , Chen Xiao-Jiao , Yang Gen-Hua , Cai Hong , Li Fan
Published: October 2023

Aconitum carmichaelii is a herbaceous herb indigenous to China that has been cultivated for traditional medicine for centuries. Virus-like symptoms of A. carmichaelii plants were observed on leaves in some A. carmichaelii plantations in Zhanyi and Wuding Counties, Yunnan Province, southwest China. High-throughput sequencing (HTS) was performed on 28 symptomatic plants, and the results revealed infection with 11 viruses, including 2 novel viruses and 9 previously described viruses: Aconitum amalgavirus 1 (AcoAV-1), aconite virus A (AcVA), cucumber mosaic virus (CMV), currant latent virus (CuLV), apple stem grooving virus (ASGV), chilli veinal mottle virus (ChiVMV), tomato spotted wilt orthotospovirus (TSWV), tobacco vein distorting virus (TVDV), and potato leafroll virus (PLRV). Two novel viruses tentatively named Aconitum potyvirus 1 and Aconitum betapartitivirus 1, were supported by sequence and phylogenetic analysis results of their genomes. We proposed the names Potyvirus aconiti and Betapartitivirus aconiti. RT-PCR assays of 142 plants revealed the predominance and widespread distribution of CMV, AcVA, and AcoPV-1 in plantations. The detection of isolates of CuLV, ASGV, ChiVMV, TSWV, TVDV, and PLRV infections for the first time in A. carmichaelii expands their known host ranges.
Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury
Authors: Konnova Elena A. , Deftu Alexandru-Florian , Chu Sin Chung Paul , Pertin Marie , Kirschmann Guylène , Decosterd Isabelle , Suter Marc R.
Published: October 2023

Satellite glial cells (SGCs), enveloping primary sensory neurons’ somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury. Glial fibrillary acidic protein (GFAP) serves as an SGC activation marker, though its DRG satellite cell specificity is debated. We employed the hGFAP-CFP transgenic mouse line, designed for astrocyte studies, to explore its expression within the peripheral nervous system (PNS) after spared nerve injury (SNI). We used diverse immunostaining techniques, Western blot analysis, and electrophysiology to evaluate GFAP+ cell changes. Post-SNI, GFAP+ cell numbers increased without proliferation, and were found near injured ATF3+ neurons. GFAP+ FABP7+ SGCs increased, yet 75.5% of DRG GFAP+ cells lacked FABP7 expression. This suggests a significant subset of GFAP+ cells are non-myelinating Schwann cells (nmSC), indicated by their presence in the dorsal root but not in the ventral root which lacks unmyelinated fibres. Additionally, patch clamp recordings from GFAP+ FABP7−cells lacked SGC-specific Kir4.1 currents, instead displaying outward Kv currents expressing Kv1.1 and Kv1.6 channels specific to nmSCs. In conclusion, this study demonstrates increased GFAP expression in two DRG glial cell subpopulations post-SNI: GFAP+ FABP7+ SGCs and GFAP+ FABP7− nmSCs, shedding light on GFAP’s specificity as an SGC marker after SNI.
Potential Significance of Serum Autoantibodies to Endometrial Antigens, α-Enolase and Hormones in Non-Invasive Diagnosis and Pathogenesis of Endometriosis
Authors: Menzhinskaya Irina V. , Pavlovich Stanislav V. , Melkumyan Arika G. , Chuprynin Vladimir D. , Yarotskaya Ekaterina L. , Sukhikh Gennady T.
Published: October 2023

The objective of the study was to evaluate the profile of serum autoantibodies and their diagnostic and pathogenetic significance in ovarian endometrioma (OEM) and deep infiltrative endometriosis (DIE). The study enrolled 74 patients with endometriosis (Group 1), including 53 patients with OEM (Subgroup 1a); 21 patients with DIE without ovarian lesions (Subgroup 1b); and 27 patients without endometriosis (Group 2). The diagnosis was confirmed by laparoscopic surgery and histologic examination of resected tissues. Antibodies (M, G) to tropomyosin 3 (TPM), tropomodulin 3 (TMOD), α-enolase (ENO), estradiol (E2), progesterone (PG), and human chorionic gonadotropin (hCG) were identified in blood serum using modified ELISA. In endometriosis, antibodies to endometrial antigens, hormones, and ENO were detected more often than antiphospholipid and antinuclear antibodies. Higher levels of IgM to TPM, hCG, E2, and PG and IgG to TMOD, ENO, E2, and hCG were found in Subgroup 1a compared to Group 2. IgM to TPM, hCG, E2, PG, and IgG to E2 and ENO had a high diagnostic value for OEM (AUC > 0.7), with antibodies to TPM having the highest sensitivity and specificity (73.6% and 81.5%). In Subgroup 1b, only the levels of IgM to TPM and hCG were higher than in Group 2. These antibodies had a high diagnostic value for DIE. Thus, endometriosis is associated with autoantibodies to endometrial antigens, α-enolase, steroid, and gonadotropic hormones. A wider spectrum of antibodies is detected in OEM than in DIE. These antibodies have a high diagnostic value for OEM and DIE and potential pathogenetic significance for endometriosis and associated infertility.
A Wide Operating Range Ejector with Part Nested Nozzles for PEMFC Hydrogen Recirculation System
Authors: Yi Anning , Wang Chen , Wang Lei , Wang Xinli
Published: October 2023

The ejector drives unreacted hydrogen from the anode to improve fuel utilization ratio and discharges redundant water to prevent flooding and shutdown in the proton exchange membrane fuel cell (PEMFC). However, the traditional fixed structure ejector cannot meet the recycling requirements in the whole dynamic working condition of the fuel cell. In this article, a part nested four-nozzle (PNFN) ejector is proposed to enhance the hydrogen recycling efficiency under variable working conditions of the PEMFC by restricting the nozzle flow as 10%, 20%, 20%, and 50% of the fuel cell-rated power, respectively. Systematical analyses are performed on the experimentally verified 3D model to study inner flow characteristics and performance under different nozzle running modes. The results indicate that the PNFN ejector satisfies the recirculation ratio requirements in the power range of 34–220 kW within the 7–9 bar suitable supply pressure. By comparing with traditional ejectors, the PNFN ejector has a wider working range and especially outputs better performance in the low power range.
Skeletal Muscle Discomfort and Lifestyle of Brazilian Military Police Officers of Administrative and Tactical Force
Authors: de Oliveira Renan Ribeiro , Aquino Jadder Bento da Costa , Reis Carlos H. O. , Oliveira Geanderson S. , Vieira Leonardo A. , Machado Alexandre F. , Rica Roberta L. , Bullo Valentina , Bergamin Marco , Gobbo Stefano , Bocalini Danilo S.
Published: October 2023

Our aim was to evaluate musculoskeletal discomfort and the lifestyle of military police officers of administrative and tactical force departments. Military police officers were distributed into two groups: administrative (Adm, n = 15) and tactical force (TF, n = 16) departments. Their lifestyle was assessed using the Fantastic Lifestyle questionnaire. Moreover, physical activity quantification was assessed using the International Physical Activity questionnaire, and musculoskeletal discomfort was quantified using the Corlett diagram. The mean total time of physical activity was 546 ± 276 min per week. No differences (p = 0.0832) were found between the Adm (454 ± 217 min) and TF (623 ± 301 min) groups. Concerning lifestyle, in general the sample presented very good (42%) and good (42%) style classification. For this parameter, no significant differences were found, but only a tendency was discovered (x2: 7.437; p = 0.0592); indeed, the TF presented a better classification (63%) of very good, compared to the Adm (53%) of good. No differences (p > 0.05) were found in musculoskeletal perception of discomfort between the right and left sides (p > 0.05) for all police officers and between the Adm and FT groups (p > 0.05). Military police officers showed high and moderate risk for waist circumference and waist-to-hip ratio, respectively; however, lifestyle and total time of physical activity were considered adequate without differences between military administrative and tactical force sectors.
Customer Segmentation as a Revenue Generator for Profit Purposes
Authors: Tavor Tchai , Gonen Limor Dina , Spiegel Uriel
Published: October 2023

The role of market segmentation in shaping pricing strategies for new products is critical. This study highlights the significance of tailoring pricing decisions in meeting the unique needs, preferences, and price sensitivities of different consumer segments in order to maximize profitability and market penetration. Understanding customer behavior and preferences in transitioning from high to low prices during new product introductions is crucial. The responses of various customer groups to price changes are essential in influencing product innovation. The model developed in this study serves two purposes: (1) to determine the optimal time to switch from high to low prices, and (2) to determine the optimal price discount when switching from high to low prices for different customer segments. Segmented marketing results in larger profits due to increased sales to loyal customers. However, deal-prone customers may purchase less when segmented.
Production of Bioactive Peptides from Hake By-Catches: Optimization and Scale-Up of Enzymatic Hydrolysis Process
Authors: Iñarra Bruno , Bald Carlos , Gutierrez Monica , San Martin David , Zufía Jaime , Ibarruri Jone
Published: October 2023

Fish by-catches, along with other fish side-streams, were previously used as raw material for the production of fishmeal and fish oil but appropriate handling allows their use in more valuable options. The aim of this research was to valorize undersized hake (Merluccius merluccius) as a model of using fish by-catch from the Bay of Biscay to produce protein hydrolysates with bioactivities. Six enzymes, with different proteolytic activities (endo- or exoproteases) and specificities, were tested to produce protein hydrolysates. Products obtained with an endoprotease of serine resulted in the most promising results in terms of protein extraction yield (68%), with an average molecular weight of 2.5 kDa, and bioactivity yield (antioxidant activity = 88.5 mg TE antioxidant capacity/g fish protein; antihypertensive activity = 47% inhibition at 1 mg/mL). Then, process conditions for the use of this enzyme to produce bioactive products were optimized using Box–Behnken design. The most favorable process conditions (time = 2 h, solids = 50% and enzyme/substrate = 2% with respect to protein) were scaled up (from 0.5 L to 150 L reactor) to confirm laboratory scale and model forecasts. The results obtained in the pilot-scale testing matched the outcomes predicted by the model, confirming the technical viability of the proposed process.
The Effect of Inorganic Nitrogen Fertilizers on the Quality of Forage Composed of Various Species of Legumes in the Northern Part of a Temperate Climate Zone
Authors: Šidlauskaitė Gintarė , Kadžiulienė Žydrė
Published: October 2023

This study focuses on the effect of inorganic nitrogen fertilizers on the quality of perennial grasses. Both grasses and legumes are important in swards, and each type of grass has different biological and ecological properties. Legumes in multi-species swards, especially in their early ages, benefit other Poaceae grasses by improving their growth. When evaluating individual cuts over a three-year period, it was determined that the quality indicators of the forage were significantly influenced by the year of use, N fertilizer application, and the different species compositions of the swards. In many cases, N fertilizers significantly reduced the CP content while tending to increase MADF and NDF. Monoculture grass swards had the highest WSC content; in most cases, N fertilizers increased the WSC content in the forage. DMD was the lowest in the first year of use, specifically in the first cut. Our three-year experiment, which investigated twelve swards with different species compositions, demonstrated that legume grasses improved the quality indicators of forage and contributed to maintaining a more stable overall forage yield over the years. As the climate continues to become warmer, there is a growing need to study a wide range of plant species and different varieties suitable for local growth conditions.
Beyond Controversy in the Hebrew Bible: Standing Stones as Messengers of Common Humanity
Authors: Viljoen Elizabeth S. Bloem
Published: October 2023

The Hebrew Bible is not only an ancient religious text, but also imbues information about the lives of people. Beyond controversial matters in the text, links can be found to common humanity with ancient roots. This renders the text not only relevant for adherents to the religions based on this text, but to all people. The exemplar followed in this article is standing stones. Biblical authors frequently refer to standing stones. These references are sharply contrasting, with some condoning and others condemning, causing contention. Archaeologically, standing stones are a ubiquitous phenomenon all over the world throughout time. They abound in the southern Levant, the region for which the Hebrew Bible is a sacred text. The meaning of standing stones is multifarious, but ultimately relates to the numinous. Among other meanings, like other vertical elements, such as mountains and trees, they play a role in shamanism, an ancient and extensive worldview. Exploration of common human traits, ascribed to inborn neurophysiological and psychological factors, divulges explanations for universal phenomena such as shamanic worldviews and the physical manifestations of such worldviews, of which the standing stone is one. Multidisciplinary evidence from archaeological, ethnographic, and textual analysis reveals that both standing stones of the southern Levant and those in the Hebrew Bible exhibit meanings related to this cosmology which flows from unconscious properties common to all people. Going beyond controversial topics allows access to common human traits linking all people, in this case adding relevance to the biblical text. This approach could elucidate the human commonality hidden behind other dissonant subjects in the Hebrew Bible.