bluuebunny/crossref_metadata_2025 huggingface dataset:
Age-related changes in the second knee area of the facialcana
Authors: Kerimzade Gulnara
Published: April 2022

The aim of the study was to measure the cross-sectional area near the second knee of the facial canal and to estimate the dependence of their values on age. Our data is of relevance for practical neuropathology, and may be one of the factors explaining the occurrence of paralysis and paresis of the facial nerve as a result of its compression in the facial canal (Bell's syndrome). Material and research methods: The material for the study was tomograms of 28 patients (11 women, 17 men) of different ages, taken from the archives of the Department of Radiation Diagnostics and Radiation Therapy, Azerbaijan Medical University (Baku, Azerbaijan). The studies were carried out on a computer tomograph "Toshiba aquilion 128 ct scanner". Computed tomography made it possible to measure the bone canal in the axial and coronal planes. Images with insufficient image quality were not included in the study. Results: This study confirmed an anatomical difference in facial canal cross-sectional area in patients of different ages. The measurements showed that with age there is an increase in the cross-sectional area of the facial canal. However, in patients aged 46–69 years, there is a noticeable decrease in this indicator. This can be attributed to a decrease in the width of the mastoid segment of the facial canal in this age group.
DISTRIBUTION OF S100 -POSITIVE CELLS IN THE STRUCTURES OF THE SPLEEN IN THE SIMULATION OF CHRONIC NORMOBARIC HYPOXIC HYPOXIA IN THE EXPERIMENT
Authors: Naumov Aleksandr , Nikitjuk Dmitry , Zadneprovskaya Ekaterina , Zhidovinov Aleksei , Shishkina Tatyana , Naumova Lyubov
Published: April 2022

The aim of the research was to study the behavior of S100-positive cells in the structures of the spleen of laboratory animals in normal conditions and against the background of chronic hypoxic hypoxia. S100-positive cells are professional antigen-presenting cells and at the same time create a microenvironment for B-lymphocytes in the corresponding B-dependent areas of the spleen. Along with this, the expression of markers such as Ki67 and p53 was defined as determining the relationship between the processes of cell regeneration and apoptosis. Chronic isolated normobaric hypoxic hypoxia was simulated on 86 white outbred male rats in special priming chambers with controlled air supply for four hours a day, five days a week for 4 months. The analysis of the data showed that as the duration of the chronic experiment increased, the expression of the p53 marker increased mainly in the B-dependent zones, while the expression of Ki67 in the analogous zones decreased. Also, as the period of chronic hypoxia increased, a significant increase in the expression of the S100 marker in the lymphoid nodules of the white pulp of the spleen was noted. In parallel with this, there is an increase in the relative volume of the T-dependent zone and a decrease in the marginal zone of the white pulp. Thus, an increase in the volume fraction of stromal components along with an increase in the expression of an apoptosis marker in lymphoid nodules of the white pulp of the spleen may indicate the formation of tension in humoral immunity and subsequent depletion of compensatory-adaptive cellular elements of the corresponding zones by the end of the experiment.
Red bone marrow damage in COVID-19 pathogenesis caused by SARS-CоV-2
Authors: Reva Ivan , Yamamoto Tatsuo , Stegniy Kirill , Slabenko Ellada , Semiglasova Viktoriya , Sementsov Igor , Lebed'ko Olga , Fleishman Marina , Kudelya Aleksey , Tuchina Mariya , Usov Viktor , Krasnikov Yuriy , Mozhilevskaya Ekaterina , Lemeshko Tatiana , Novikov Aleksey , Tolmachev Valeriy , Reva Galina
Published: April 2022

With the emerging of new strains of the SARS-CoV-2 coronavirus (such as B.1.1.529 for example), despite numerous studies to create effective vaccines, it becomes obvious that the relevance of studying the pathomorphology of tissue structures with damaged cellular targets has increased manifold. Most knowledge on genes of pathogenicity loses its importance for the development of antiviral agents since the reservoir for the virus is the cells, in which SARS-CoV-2 then persists. These data are more important for the development of vaccines, and the treatment strategy should be based on damaged cellular targets. The mechanisms of hypoxia in patients infected by SARS-CoV-2 with COVID-19 do not have an exhaustive explanation based only on the acute alveolar damage. Our investigation deals with the data on pathologic red bone marrow in patients with a fatal COVID-19 outcome against the background of various indicators of erythrocytes in clinical blood tests. We found in the structure of the red bone marrow that there is damage to the stroma and parenchyma as well as pathomorphological signs of damage to erythropoiesis in the patients of both groups. The data obtained on the cellular targets of SARS-CoV-2 can serve as a fundamental platform for the development of targeted conservative therapy in the treatment of patients infected with SARS-CoV-2, and should also be taken into account in severe COVID-19 cases with the risk of unfavorable prognosis.
Hop-Count Aware Wireless Body Area Network for Efficient Data Transmission
Authors: Iyobhebhe Matthew , Usman Aliyu D , Tekanyi A M , Agbon Ezekiel Ehimen
Published: April 2022

This work focuses on the clustering in Wireless Body Area Network (WBAN). Recently, it was found  that less attention was given to Line-of-Sight (LoS) and Non-Line-of-Sight (NLoS) clustering in WBAN. Past works on LoS clustering WBAN consider the problem of enhancing the network throughput and end-to-end delay of the network. However, the problem of necessary hop count for packet transmission has not been considered. The non-consideration of necessary nodes hop count degrades the performance of cluster-based WBAN as throughput of the network is reduced in addition to high end-to-end delay. This work develops a hop count aware WBAN for enhancing the performance of body nodes called improved Dual Sink Approach using Clustering in Body Area Network (iDSCB). The simulation results depicted that the hop distance criterion of iDCSB improved the performance of WBAN in terms of end-to-end delay and throughput by 3.16% and 6.59%, respectively.
PENGARUH AIR REBUSAN DAUN KARSEN TERHADAP PENURUNAN KADAR KOLESTEROL PADA LANSIA
Authors: Sry Wahyuni Sry Wahyuni , Sumiyati Sumiyati , Masyitah Wahab Masyitah Wahab
Published: April 2022

Someone with high risk of blood cholesterol up to 200 mg/dL is having high risk of health problems. And the higher the cholesterol rate, the higher the risk of heart and blood vessels. Kersen leaf dust (m. calabura l.) Saponin lowered cholesterol ingrate and increased in secretion, flavonoid caused a reduction in transfusion HMG-CoA to mevalonat, resulting in cholesterol synthesis decline. The goal of this study is to prove the effects of carsen stew's water on decreasing the cholesterol level of the elderly. This method of research is eskperimental design using a one-group pretest-posttest design model, it USES 10 old samples that have cholesterol levels above 200 mg/ dl and are willing to be cited for respondents with samples of a sampling exercise. Data gained from cholesterol levels before and after an intervention on the observation sheet using normal distribution saphiro wilk test has a p-value > 0.05. The normality test using the partner t test acquired data with the grade of p-value = 0.030 < 0.050 this indicates ho is rejected, thus assessing a different cholesterol level before and after the water treatment of carsen leaves against cholesterol sufferers.
PENCEGAHAN TEKANAN DARAH TINGGI PADA LANSIA PENDERITA HIPERTENSI DENGAN METODE WALKING EXERCISE
Authors: Nur Isriani Najamuddin Nur isriani , Lisda Alvita Lisda Alvita , Alya Andriani Alya Andriani
Published: April 2022

Hypertension is a condition where a person experiences an increase in blood pressureblood is above normal and chronic. Hypertension in Indonesia is a problem health with the highest prevalence of 25.8%, the prevalence of Province West Sumatra by 22.6%. Data from Mamasa district, there are 19,559 cases of hypertension with details of 6,891 men and 6,891 women (Mamasa Health Office, 2019). Treatment of hypertension is done by pharmacological and non-pharmacological treatment. One of the non-pharmacological treatments for hypertension is physical activity, namely by walking. This research is an Experimental Design with a Control Group Pre-Posttest approach. The study was carried out from April to May 2021. The sampling method was carried out by purposive sampling, totaling 40 people. The sample was divided into 2 groups, namely 20 treatment samples and 20 control samples. Primary data includes data on respondents' initial and final pressure, while secondary data includes general data on respondents. The data were analyzed using the Paired T Test statistical test. These results indicate an average decrease in systolic and diastolic blood pressure in the groups of 13.40 mmHg and 13.60 mmHg, respectively. The results of the Paired T Test with a p value of 0.000 indicate that there is an effect of the walking exercise method on blood pressure in the elderly (aged 55-60 years) with hypertension in Aralle Village, Aralle District, Mamasa Regency. Suggestions from this study are the walking exercise method can be used as an alternative to non-pharmacological treatment to help lower blood pressure.
PREVALENSI HIPOKALEMIA DAN HIPONATREMIA PADA PASIEN
TUBERKULOSIS MULTIDRUG RESISTANCE DI RS. HASAN SADIKIN BANDUNG
Authors: Mulya Harahap Raja Iqbal , Tristina Nina , Rostini Tiene , Suraya Nida
Published: April 2022

Tuberkulosis Multidrug Resistance (TB MDR) adalah infeksi M. tuberculosis yang resisten
rifampisin, isoniazid, atau obat antituberkulosis lainnya. TB MDR dapat menyebabkan
berbagai komplikasi baik lokal ataupun sistemik seperti electrolyte imbalance, termasuk
hiponatremia dan hipokalemia. Hiponatremia dan hipokalemia pada pasien TB MDR
disebabkan oleh berbagai faktor seperti invasi ke organ lain, Syndrome Inappropriate
Antidiuretic Hormone (SIADH), asupan rendah, serta efek samping pengobatan. Penelitian ini
bertujuan untuk mengetahui prevalensi hiponatremi dan hipokalemi pada penderita TB MDR.
Penelitian adalah deskriptif retrospektif dengan data pasien baru TB MDR. Subjek adalah 115
pasien yang berobat di Poliklinik TB MDR RSHS Bandung yang memeriksakan elektrolitnya
di laboratorium RSHS. Subjek penelitian laki-laki (54,8%) lebih banyak dibanding subjek
penelitian wanita (45,2%), dengan rerata usia pasien 38,06 ± 12,83 tahun. Rerata kadar
natrium adalah 136±4 mEq/L, 67% subjek memiliki kadar natrium normal, dan 33% subjek
memiliki kadar natrium di bawah normal. Rerata kadar kalium adalah 3,9±0,5 mEq/L, sebesar
85,2% subjek memiliki kadar kalium normal, dan 14,8% subjek memiliki kadar kalium di
bawah normal. Hiponatremia pada pasien MDR disebabkan asupan kurang, anoreksia dan
SIADH. Hipokalemia dapat disebabkan efek samping pengobatan TB sebelumnya, dan
peningkatan katabolisme protein yang menyebabkan efluks kalium dari plasma. Hiponatremia
pada pasien memiliki prevalensi sebesar 33%, dan Hipokalemia sebesar 14,8%.
LAPORAN KASUS PERBEDAAN EKSTRIM ANTARA OFFICE DAN
AMBULATORY BLOOD PRESSURE: APAKAH BENAR SEBUAH HIPERTENSI
TIDAK TERKONTROL?
Authors: Pujiwaskito Prihati , Tartila Tami Sertilia , Khamarul Jannah Fatimah Defina , Tafriend Novaro Adeneur
Published: April 2022

White Coat Uncontrolled hypertension (WCUH) menjadi salah satu pertimbangan yang dinilai
pada pasien hipertensi tidak terkontrol. Penilaian lebih jauh dibutuhkan untuk menghindari
terjadinya medikasi berlebihan. Pada penelitian ini, penulis meneliti sebuah kasus WCUH
yang ekstrem, yang ditemukan pada saat melakukan pemeriksaan ambulatory blood pressure
monitoring (ABPM). Subyek penelitian adalah perempuan berusia 66 tahun pasien rutin poli
rawat jalan departemen jantung RSPAD Gatot Soebroto dengan diagnosis hipertensi tidak
terkontrol, Coronary artery disease (CAD) post Percutaneous Coronary Intervention (PCI),
dan diabetes melitus tipe 2. Pasien termasuk ke dalam kategori overweight dengan kadar gula
darah yang tidak terkontrol dan diberikan terapi hipertensi agresif yang diberikan dengan,
Angiotensin Receptor Bloker (ARB), Calcium Chanel Blocker (CCB), Beta Blockers, diuretik
dan klonidin, tekanan darah sistolik pasien masih terukur 160 mmHg di poliklinik. Hasil
ekokardiografi menunjukkan adanya hiperterofi konsentrik ventrikel kiri. Hasil pemeriksaan
ABPM menemukan bahwa rerata tekanan darah dua puluh empat jam pasien adalah 93,6/59
mmHg, dengan rerata tekanan darah day-time 90/55 mmHg dan night time 98,7/65.2 mmHg,
serta hipotensi intermiten dengan reverse dipper pattern. Tekanan darah terendah yang
terekam adalah 69/44 mmHg, dan tekanan darah tertinggi terukur pada 211/186 mmHg.
Pasien terdiagnosis dengan White Coat Uncontrolled Hypertension (WCUH), dan melakukan
penyesuaian terapi yang diberikan. Kasus ini menekankan perlunya identifikasi dan eksklusi
diagnosis WCUH pada pasien hipertensi tidak terkontrol dengan ABPM supaya pasien
mendapatkan terapi yang sesuai dan mencegah hipotensi yang tidak diinginkan.
TELAAH PUSTAKA: SINDROM HEPATOPULMONAL
Authors: Kusmala Yudith Yunia
Published: April 2022

Sindrom hepatopulmonal (HPS) didefinisikan sebagai adanya defek oksigenisasi arterial yang
diinduksi oleh vasodilatasi intra pulmonal akibat dari penyakit hepar lanjut. Sindrom ini
ditandai oleh tiga gejala utama yaitu penyakit hepar yang lanjut, hipoksemia arteri (PO2 arteri
<70 mmHg atau gradien oksigen arteri–alveolar >20 pada udara ruangan) serta vasodilatasi
intra pulmonal. Sindrom hepatopulmonal adalah salah satu komplikasi dari sirosis hepatis dan
umumnya menunjukkan prognosis yang buruk. Prevalensi kejadian HPS pada sirosis
bervariasi antara 4%-32 %. Makalah ini menjelaskan kriteria diagnosis, patogenesis,
patofisiologi, diagnosis, diagnosis banding, pengelolaan dan prognosis sindrom
hepatopulmonal. Saat ini HPS menjadi penting untuk dikenali dalam menentukan
keberhasilan transplantasi hepar.
ANALISIS POSTUR KERJA PADA PROSES PEMOTONGAN TEMPE DENGAN METODE OCCUPATIONAL REPETITIVE ACTION (OCRA) UNTUK MENGURANGI KELUHAN MUSKULOSKELETAL
Authors: - Ikha Fera Agustin , Siswiyanti  , Zulfah
Published: April 2022

Proses pemotongan tempe dilakukan secara manual dan repetitive. Dari studi pendahuluan pada 15 dengan penyebaran kuesioner Nordic Body Map pekerja mengeluhkan nyeri 20% pada bahu kanan, 67% punggung dan tangan kanan, 40% lengan atas kanan, tangan kiri, kaki kiri, 53% pinggang, 27% lengan bawah kanan, 47% lutut kiri dan kanan, serta 60% kaki kanan. Pengumpulan data dilakukan dengan beberapa cara yaitu pengamatan langsung, tanya jawab, kuesioner, eksperimen, serta studi pustaka. Penelitian ini bertujuan memberikan usulan perbaikan fasilitas kerja menggunakan metode Occupational Repetitive Action (OCRA). Hasil analisis postur kerja berdasarkan OCRA Index dengan meja yang lama diperoleh skor tangan kanan 2,6 dalam kategori yellow berarti keadaan perlu diperbaiki, untuk skor tangan kiri 3,7 dalam kategori red-low berarti keadaan berisiko rendah. Dalam hal ini peneliti memberikan usulan perbaikan fasilitas kerja berupa meja yang ergonomis dengan mengacu pada antropometri pekerja dan ketinggian meja dapat dinaik-turunkan dengan sistem knock down disesuaikan dengan tinggi badan pekerja.
Etiological observation of Children with Acute Kidney Injury in a Tertiary Care Hospital
Authors: F Ahmed , M Hanif , T Fardush
Published: April 2022

Introduction: Acute Kidney Injury (AKI), formerly known as Acute Renal Failure, is characterized by a reversible increase in creatinine and nitrogenous waste product concentrations in the blood, as well as the kidney's failure to maintain proper fluid and electrolyte balance. Whether the etiology of AKI varies by area, the incidence of AKI in children appears to be increasing. The etiology of AKI in hospitalized children has shifted from primary renal disease to various causes during the last several decades, particularly in hospitalized children. As a result, further study is needed to determine the most recent trends in AKI in this region. Aim of the study: The aim of the study was to observe the etiology and its effect on outcome on children. Methods: This prospective longitudinal study was performed in the Department of Pediatrics, Dhaka Shishu Hospital, Dhaka, during the period of 12 months from January 2015 to December 2015. A total of 50 children were selected from the ones admitted into the hospital following the inclusion and exclusion criteria. A detailed history was taken, thorough physical examination and relevant laboratory investigations were done in all enrolled patients. All underwent necessary supportive care as needed until discharge or death. Result: In the present study, the mean age of the children was 2.8 ± 1.9 years, with the youngest one being 4 days and the oldest, 12.5 years. Male: female ratio was 1.8:1. Children in the age group of 1-5 years were most commonly affected. Pre-renal cause was the most common cause of acute kidney injury, present in 64% of the cases, and diarrheal complication was the most common disease in pre-renal cases. Mean serum creatinine were extremely high with Mean±SD levels of 4.03±2.81 (mg/dL). Conclusion: It was observed that, AKI was more common in early childhood (less than 5 years) than more than 5 years. Pre-renal causes etiology was the most common among the participants, and majority of the pre-renal.......
Effects at the Thyroid Level of the use of Lithium in Bipolar Patients
Authors: Restrepo Daniela Carolina Salcedo , Dussan Diego Alexander Rios , Becerra Ludin Alexandra Rueda , Pérez Cindy Goretti Thola , Celins Luis José Payares , Muñoz Ricardo Antonio Rendón , Alejandra Claudia
Published: April 2022

Background: Mood disorders also known as affective disorders include unipolar and bipolar disorders. Manic-depressive disorder, more contemporary identified as bipolar disorder, is a chronic and complex disorder. Mood stabilizers and antipsychotics are the mainstay of acute treatment for bipolar mania and depression. Lithium is the gold standard for treating bipolar disorder. Methodology: A narrative review was carried out through various databases from January 2009 to November 2021; the search and selection of articles was carried out in journals indexed in English. Keywords were used: Thyroid; lithium; bipolar; Thyroiditis; Goiter; Hypothyroidism. Results: Lithium is abundantly present at the thyroid level, the uptake of iodine being reduced. Causing as a collateral effect the increase in TSH, increasing uptake. These various alterations caused by lithium can lead to developing goiter and hypothyroidism, being the most frequent. Conclusions: This review offers an updated approach to the pathophysiological mechanisms caused by lithium as well as the main alterations produced by it.
Urinary Neutrophil Gelatinase Associated Lipocalin, As a Diagnostic Marker of Acute Kidney Injury in Cirrhotic Patients
Authors: Islam Md. Rofiqul , Islam Md. Shafiqul , Ahmad Nooruddin , Hasan S. K. M Nazmul , Khan Mohammad Nurul Islam , Sultana Mst. Musarrat
Published: April 2022

Background: Acute kidney injury leads the liver cirrhosis patients to the doom of multiorgan failure. The acute kidney injury diagnosis in the early possible period in the hospitalized cirrhotic patients can save many lives. But it is difficult to detect acute kidney injury early without conventional biochemical tool, serum creatinine. Abrupt increase of the level of serum creatinine by at least 0.3 mg/dL may be termed as acute kidney injury. It may occur in about 20% of hospitalized patients in decompensating liver cirrhosis. The commonest causes of acute kidney injury in cirrhotic patients are pre-renal azotemia, hepatorenal syndrome and acute tubular necrosis. Objective: The aim of this study was to assess of an increase urinary Neutrophil Gelatinase Associated Lipocalin level predicts the development of acute kidney injury in cirrhotic patients, to determine the accuracy of urinary Neutrophil Gelatinase Associated Lipocalin as a diagnostic marker of acute kidney injury in cirrhotic patients and to find out the cut off value of urinary Neutrophil Gelatinase Associated Lipocalin level to diagnose acute kidney injury in cirrhotic patients. Materials and methods: This was a cross sectional study at the department of hepatology, BSMMU, Dhaka, during September 2016 to April 2017. Total 70 hospitalized patients with decompensated cirrhosis & decompensated cirrhosis with AKI prone condition and who fulfilling the inclusion and exclusion criteria were included in this study. Patient with co-morbid condition (COPD, CKD, CCF etc.), history of pre-existing liver or kidney transplantation, hemodialysis and urinary tract obstruction were excluded from this study. Results: The mean age of the respondents was 43.49±12.46 years and 46.09±14.90 years in Group A and Group B respectively. Twenty six (74.3%) were male and 9 (25.7%) were female in Group A. Twenty seven (77.1%) were male and 8 (22.9%) were female in group B. Male patients were predominant in both groups. .............
Influence of Age on Sleep Deprivation Induced Oxidative Stress in Different Brain Regions of Young and Old Rats
Authors: Raina Neha , Chauhan Dushyant Singh , Tripathi Sandeep
Published: April 2022

Sleep plays a crucial role in maintaining brain function and neuronal signalling and helps maintain overall health of the individuals. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. The aim of the present study was to investigate the SD induced oxidative stress with advancing age in different brain regions. In the present study, young and old rats were taken as control and experimental rats (n=6) respectively. Lipid peroxidation and protein oxidation significantly increased (p<0.05) and reduces antioxidant levels in experimental young and old rats. The most affected part of the brain was hippocampus followed by cerebral cortex. The biochemical changes observed in SD treated young rats were comparable to those of untreated old control rats. Therefore, SD may play a role in the premature aging of animals.
Aplicação de técnicas envolvendo miRNA nos processos patológicos autoimunes
Authors: Santos Lázaro Araújo
Published: April 2022

O sistema imune é formado por vários componentes que harmoniosamente nos protege contra diferentes agentes patogênicos. Contudo, devido a eventos pouco conhecido esse sistema acaba perdendo a capacidade de descriminar o que é próprio do organismo daquilo que não é, originando doenças autoimunes. Dentre as diferentes maneiras que os pesquisadores vêm utilizando para estudar e, consequentemente, desenvolver terapias para o tratamento dessas enfermidades, destaca-se a manipulação de miRNA’s. Levando em consideração que essa tecnologia é recente e que é preciso compreender o que já existe sistematizado para que seja possível observar as eventuais lacunas no conhecimento cientifico e, a partir delas traçar novas metas, o presente trabalho possui como objetivo analisar como as produções nacionais tem apontado a utilização de técnicas baseadas em miRNA relacionado a doenças autoimune. Para tanto, foi realizada buscas bibliográficas nas plataformas Google acadêmico, Scielo, PubMed e MedLine, utilizando como descritores: Aplicação; Autoimune; miRNA; Processos imunológicos. Foram obtidas 86 produções, sendo 55 analisadas. Após análise inferiu-se 4 categorias: estudos relacionados ao desenvolvimento de células T e B; Análise dos miRNA associados a doenças autoimune no geral; Análise dos miRNA associados a enfermidades autoimune específicas; e terapias associadas miRNA. Além de ser possível averiguar as seguintes lacunas:  conhecimento incompleto dos processos biológicos realizadas pelos miRNA’s, a escassez de técnicas que possibilitem manipular o RNA dada sua instabilidade, o desconhecimento existente sobre o comportamento do genoma e, se tratando do âmbito nacional, a falta de investimento tanto para capacitar mão de obras quanto em proporcionar infraestrutura adequada. Assim, conclui-se que há uma urgente necessidade de pesquisas com objetivos não apenas na aplicação de técnicas associadas ao miRNA, mas, também na compreensão dessa maquinaria a fim de que possamos compreender quais as estruturas envolvidas no processo protagonizado por essas moléculas e como poder-se-á manipulá-las com finalidades terapêuticas
Elaboração de massa alimentícia fresca a partir das farinhas de banana da terra (Musa sapientum) e aveia (Avena sativa)
Authors: Gonçalves Adrielly , De Paula Juliana Maria , De Brito Sodré Lainy Waleska , Geraldi Claudineia Aparecida Queli , Guedes Sumaya Ferreira , Loss Raquel Aparecida
Published: April 2022

Este trabalho teve como objetivo elaborar uma massa alimentícia fresca a partir de farinhade banana da terra verde in natura (Musa sapientum) e farinha de aveia (Avena sativa), isentas de glúten em diferentes formulações. A polpa de banana da terra verde in natura foi submetida a um processo de secagem em estufa de circulação de ar forçado em temperatura de 80 ºC. Para cada tipo de farinha de banana obtida foram configuradas três formulações de massa fresca que se diferenciam nas proporções de farinha de banana daterra verde e farinha de aveia: Formulação 1 (75% de farinha de banana da terra verde +25% de farinha de aveia); Formulação 2 (50% de farinha de banana da terra verde + 50% de farinha de aveia); Formulação 3 (25% de farinha de banana da terra verde + 75% de farinha de aveia). Foram realizadas análises físico-químicas, de qualidade tecnológica e de qualidade microbiológica As análises físico-químicas avaliaram os teores de umidade,cinzas, pH, acidez titulável e proteínas. As análises de qualidade tecnológica verificaram o tempo de cozimento, aumento de massa e perda de sólido, por fim, as análises microbiológicas mediram coliformes totais, coliformes termotolerantes e bolores eleveduras. Os resultados obtidos mostram que o processo de secagem realizado se ajustou ao modelo matemático proposto por Henderson e Pabis. As formulações apresentaram um teor de umidade médio de 45,82%, acidez 1,007%, proteínas 4,84%,cinzas 1,95%, lipídeos 4,3% e pH de 5,77. Nas análises tecnológicas, todas as formulações avaliadas resultaram em uma massa alimentícia de alta qualidade tecnológica. De modo geral, levando em consideração todos os parâmetros analisados, conclui-se que a elaboração de massas a partir das farinhas de banana da terra verde e aveia é promissora, especialmente, para a formulação 3, que apresentou maior teor proteico e menor tempo de cozimento.
USO DE BIOMATERIALES COMO ALTERNATIVA PARA LA REMEDIACIÓN DE JALES MINEROS
Authors: Siqueros Valencia Jesus Rafael , Loredo Portales Rene , Moreno Rodríguez Verónica , Del Rio Salas Rafael
Published: April 2022

Los beneficios de la industria minera son innegables, sin embargo, los residuos son frecuentemente asociados con problemáticas medioambientales, debido la presencia de elementos potencialmente tóxicos. Las técnicas de remediación propuestas son diversas, aunque recientemente se ha popularizado el uso de biomateriales como una alternativa sustentable económica, en donde se utilizan biomateriales adsorbentes sintetizados mediante pirólisis de desechos biológicos. En este trabajo se probó al bone char (BC; bio hidroxiapatita), sintetizado a partir de huesos de ganado vacuno para la remediación de jales mineros históricos de San Felipe de Jesús, Sonora, mediante un diseño experimental factorial. Los resultados mostraron que el BC disminuye la producción de sales eflorescentes, además de amortiguar parámetros como el pH y CE, demostrando su potencial para el tratamiento de drenaje ácido de mina.
SERVQUAL ANALYSIS TERHADAP KEPUASAN PELANGGAN DI BENGKEL OMEGA LESTARI MANDIRI
Authors: Pratama Adi Negoro Yudha
Published: April 2022

Dalam usaha melayani kebutuhan pelanggan, Bengkel Omega Lestari selalu ingin meningkatkan kualitas pelayanannya. Dengan banyaknya kompetitor yang ada membuat Bengkel Omega Lestari harus dapat mempertahankan pelanggan yang diinginkan. Tujuan penelitian ini adalah untuk mengetahui tingkat kepuasan konsumen Bengkel Omega Lestari. Penelitian ini dilakukan dengan menyebarkan kuesioner kepada 85 pelanggan bengkel. Hasil kuesioner tersebut dianalisis dengan menggunakan metode SERVQUAL dan IPA. Terdapat 5 dimensi yang diukur yaitu tangibles, reliability, responsiveness, assurance, dan emphaty.hasil, berdasarkan usulan perbaikan yang Bengkel Omega Lestari adalah evaluasi dan perbaikan dari para pekerja bengkel dan melakukan kegiatan bersih-bersih lingkungan bengkel maupun peralatan yang lain agar terlihat rapi,

 

Kata kunci : Importance Performance Analysis; kepuasan pelanggan; SERVQUAL
IMPLEMENTASI ARC DAN ARD UNTUK MENURUNKAN OMH PADA DESAIN ULANG TATA LETAK FASILITAS LABORATORIUM
Authors: Aji Sonny
Published: April 2022

Penelitian ini dilakukan dengan tujuan untuk mengetahui aliran perpindahan material untuk menghasilkan tata letak fasilitas laboratorium Quality Control pada perusahaan farmasi, untuk mengurangi jarak perpindahan dan ongkos material handling (OMH) atau biaya penanganan material.  Permasalahan yang dihadapi pada tata letak awal laboratorium ini adalah aliran proses pada area kerja laboratorium yang tidak tersusun dengan baik.  Jarak antar area masih belum efisien sehingga berpengaruh pada integrasi pekerjaan yang ada pada aliran proses kerja.  Ketidakefisienan akibat jarak antar area ini mengakibatkan timbulnya biaya penanganan material yang cukup besar.  Activity Relationship Chart (ARC) dan Activity Relationship Diagram (ARD) dilakukan berdasarkan derajat kedekatan antar fasilitas untuk kemudian dibuat tata letak usulan.  Desain ulang tata letak fasilitas laboratorium dilakukan untuk menurunkan jarak perpindahan dan biaya penanganan material.  Hasil penelitian dengan menggunakan ARC dan ARD didapatkan penurunan jarak perpindahan menjadi 1.718,10 meter dan biaya penanganan material (OMH) sebesar Rp2.772.240,26.  Efisiensi yang dihasilkan pada layout usulan adalah sebesar 42,24% dari layout awal.
IDENTIFIKASI PROSES PRODUKSI TROLI PADA KEGIATAN PRAKTIKUM SISTEM PRODUKSI PRODI TEKNIK INDUSTRI UBP KARAWANG
Authors: Farida Risqi Nur Safitri
Published: April 2022

Suatu produk atau komponen akan dibuat sendiri, maka diperlukan tahapan untuk menentukan bagaimana produk atau komponen tersebut akan diproduksi. Produk atau komponen yang berbeda, biasanya membutuhkan teknologi, mesin, peralatan dan proses kerja yang berbeda. Analisis proses produk memberikan deskripsi secara detil tentang proses produksi dan perakitan setiap komponen, waktu produksi, material serta peralatan yang dibutuhkan. Dalam melakukan analisis proses, selain assembly chart dan route sheet,diperlukan alat analisis lainnya seperti peta proses operasi (operation process chart/OPC). Peta kerja ini merupakan salah satu alat yang digunakan untuk memberikan informasi kegiatan kerja produksi secara sistematis. Melalui peta ini,setiap langkah dan perlakuan terhadap suatu benda kerja dapat dianalisis. Para pekerja dan operator akan mengetahui kapan harus memulai aktifitas berikutnya dengan menngacu kepada penanda yang diberikan sistem Kanban, yang dapat berupa kartu, kontainer, email, atau pesan elektronik lainnya
Принципи реалізації Bluetooth 5.2: апаратна реалізація.
Authors: Ozerchuk І.
Published: April 2022

У статті розкрито принципи реалізації Bluetooth 5.2 з точки зору апаратної реалізації. Описано еволюцію технології Bluetooth, наведено інноваційні функції Bluetooth 5.2, визначено основні переваги. Розкрито механізм встановлення зв’язку та описано етапи реалізації останнього. Запропоновано алгоритм формування з’єднання точка-точка за технологією Bluetooth з детальним описом процесу. Охарактеризовано стек протоколів Bluetooth. Визначено функціональну приналежність кожного протоколу та описано принцип взаємодії поміж протоколами. Наголошується, що в умовах сьогодення, низка сучасних компаній інтегрували основні функції широкої смуги Bluetooth в апаратне забезпечення, інші компанії, надають інтерфейс керування хостом. Підкреслено, що система на основі ARM для реалізації Bluetooth передачі у своєму складі має низку додаткових компонентів з’єднаних поміж собою шиною даних. Схематично представлено взаємодію апаратного забезпечення Bluetooth з встановленням функціональних зв’язків. Обґрунтовано принцип реалізації шифрування даних (функція потокового шифру) в апаратному забезпеченні. Наголошується, що застосування функції потокового шифру в апаратному забезпеченні знімає безперервне навантаження з процесора по бездротовому каналу під час передачі даних, а реалізація механізму генерації ключів та аутентифікації в апаратному (а не програмному) забезпеченні призводить до швидшого часу підключення та мінімізації споживання енергії. Запропонована архітектура системи для реалізації апаратного забезпечення Bluetooth 5.2 з урахуванням функції крипто захисту, описано потоки зв’язків на базі системи та описано кожен наявний функціональний блок з відокремленням власної приналежності та виконуваних завдань. Описано широту спектру застосування Bluetooth 5.2 з виділенням таких сфер як: розумні пристрої; засоби масової інформації (телебачення, радіомовлення); подвійна трансляція (функція подвійної трансляції, допомагає у передачі ідентичної інформації через обладнання LE Audio та дубль через гарнітуру Bluetooth або відповідний мобільний додаток, це може значно заощадити час та енергію); багатомовний переклад у режимі реального часу (дана функція зручна при спілкуванні на різних мовах, чи прослуховуванні інформації різними мовами).
Discutindo as Concessões de Uso Público em Unidades de Conservação Brasileiras
Authors: Correa Moro Carolina , Omena Michel Tadeu R. N. de , Cristina Magro Lindenkamp Teresa
Published: April 2022

Cresce, junto à sociedade brasileira, o reconhecimento da importância das áreas protegidas como provedoras de benefícios sociais, culturais e econômicos, o que inclui a oportunidade de praticar atividades recreativas nesses locais como expressão do direito social ao lazer. Contudo, os recursos humanos para receber esses visitantes, bem como a oferta de atividades e a falta de infraestrutura ligada aos serviços têm sido uma importante questão para os órgãos gestores, principalmente quando se fala em unidades de conservação da categoria parques. Essa conjuntura não deve levar à continuidade da condição de “parques fortaleza”, onde a visitação fica restrita às ações de educação ambiental. As parcerias com outras empresas, instituições ou comunidade local são uma das formas de lidar com essa questão. Dentre as opções de parceria, há uma priorização nos últimos anos para a concessão dos serviços de uso público em unidades de conservação (UCs) para a iniciativa privada, em especial em parques. Este artigo traz reflexões sobre os processos de concessão como instrumento para melhoria dos serviços de apoio ao uso público nas UCs e como forma de melhorar os sistemas de manejo dessas áreas. Destacamos questões relevantes sobre o tema, buscando provocar o leitor ou leitora a pensar sobre as concessões em parques. Será este o único ou melhor caminho para o desenvolvimento do uso público nas áreas naturais brasileiras neste momento?
Antcin C Enhances Cellular Apoptosis of Hepatic Carcinoma Cells by Modulating Phosphoinositide 3-Kinases/Protein Kinase B/The Mammalian Target of Rapamycin Pathway
Authors: Ti Zhenyu , Wang Xiaofeng , Xu Quanlin , Wu Xiaojun , Chen Wenhao , Yan Man
Published: April 2022

The present study has evaluated the role of Antcin C in hepatic carcinoma and its possible mechanism of action. The results show that Antcin C causes a significant dose-dependent reduction in cell viability, cell migration and invasion, and enhancement of apoptosis. Moreover, treatment with Antcin C significantly reduces the expression of phosphoinositide 3-kinases/protein kinase B protein in Hep-G2 cells in a concentration-dependent manner. In conclusion, data of the present investigation supports that Antcin C enhances apoptosis in hepatic carcinoma by inhibiting the phosphoinositide 3-kinases/ protein kinase B pathway.
Religious Values Applied By Women In Kakawin Arjuna Wiwaha
Authors: Selasih Ni Nengah
Published: April 2022

Kakawin Arjuna Wiwaha tells of Sang Arjuna's marriage to a female companion who has a woman's role and position. Diah Supraba has an angel who is also implied in Kakawin Arjuna Wiwaha, who have their respective roles and positions that inspire women in the era of globalization. The purpose of this study was to analyze the religious values ​​contained in kakawin arjuna wiwaha that can be applied by women. The method used in this research is descriptive qualitative. The data collection technique in this research is a literature study on Kakawin Arjunawiwāha which consists of 36 pupuh, 354 stanzas and 24 kinds of metres. This Kakawin was written by Mpu Kanwa during the reign of King Airlangga (1019-1042) between 1028 and 1035 AD. This study describes the religious values ​​shown by women in Arjuna Wiwaha's kakawin, namely 1) Purity (sivam), a woman is obliged has purity both physically and spiritually in her like a Goddess. 2) A woman who has a strong patience is Diah Suprabha, ordered by Hyang Indra to investigate the secret of the power of a powerful giant named Niwatakawaca, with full devotion to carry out the task at hand with great patience; 3) Diah Tilotama's love is so great and sincere, it can be seen from the restlessness of her heart seeing her husband who is upset and trying to comfort his husband's heart; 4) The nymphs are verydevoted/ obedient to everything that is ordered by Lord Indra 5) The nymphs (Diah Suprabha) are loyal to the king of heaven, so that all orders are never rejected even though they have to sacrifice their bodies 6) The angel who is most seen making sacrifices is Diah Suprabha who was willing to sacrifice himself to go directly to the enemy from Indraloka who was the most feared, namely Niwatakawaca. Kakawin Arjuna Wiwaha as a guide and learning for women to become strong women.
ПРО РОБОТУ ВІДДІЛЕНЬ ТА НАУКОВИХ УСТАНОВ НАЦІОНАЛЬНОЇ АКАДЕМІЇ ПЕДАГОГІЧНИХ НАУК УКРАЇНИ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Kremen Vasyl , Lugovyi Volodymyr , Topuzov Oleh , Sysoieva Svitlana , Maksymenko Serhii , Liashenko Oleksandr , Nychkalo Nellia , Saukh Petro , Lukianova Larysa , Reheilo Iryna , Hudym Iryna
Published: April 2022

У доповідях в.о. президента НАПН України В.Г. Кременя, в.о. академіків-секретарів відділень НАПН України С.О. Сисоєвої, С.Д. Максименка, О.І. Ляшенка, Н.Г. Ничкало, П.Ю. Сауха та директора Інституту педагогічної освіти і освіти дорослих імені Івана Зязюна НАПН України Л.Б. Лук’янової розгорнуто представлено роботу академії, її відділень та наукових установ в умовах воєнного стану, запровадженого і продовженого відповідно до указів Президента України у зв’язку з широкомасштабною збройною агресією Російської Федерації проти України. НАПН України висловлює безумовну підтримку керівництву держави, Президенту України В.О. Зеленському та Збройним Силам України, їх зусиллям, спрямованим на захист суверенітету і територіальної цілісності України, вшановує пам’ять тих, хто віддав за неї життя, та засвідчує глибоке переконання у здобутті перемоги українського народу. НАПН України засуджує військову агресію Російської Федерації проти України, постійне і грубе порушення принципів та норм міжнародного права щодо гарантій суверенітету і територіальної цілісності України як незалежної держави, жорстке поводження з мирним населенням, зокрема дітьми, що призводить до численних людських жертв, та, незважаючи на складну ситуацію, вірить у швидке переможне завершення війни. НАПН України вважає, що в умовах порушення Російською Федерацією загальновизнаного міжнародного права, вчені-громадяни цієї країни та Республіки Білорусь, які явно або мовчазно підтримали військові дії агресора, не можуть бути частиною цивілізованого академічного світу, не можуть бути іноземними членами, почесними докторами НАПН України, реалізовувати будь-які спільні проєкти, та закликає міжнародну наукову спільноту до припинення будь-якої співпраці з такими російськими і білоруськими вченими, науковими колективами, розірвання з ними грантових угод. Зроблено висновок, що відділення, наукові установи академії беруть активну участь у протидії російській агресії, здійснюють заходи з посилення ефективності діяльності задля прискорення перемоги, розвитку науки і освіти, економіки країни загалом. Зокрема, розкрито зміст науково-організаційних заходів; міжнародної інформаційно-просвітницької діяльності і підтримки інформаційної безпеки; волонтерської допомоги вчених НАПН України; наукової та науково-організаційної роботи наукових установ НАПН України; співпраці з МОН України та закладами освіти; психологічного супроводу освітянської спільноти та психологічної підтримки населенню в кризових умовах тощо.
Diagnóstico e tratamento do melanoma vaginal: relato de caso
Authors: Gomes Sophia Helena Dal Rio , Brisighelli Neto Attilio
Published: April 2022

Introdução: Os melanomas com localização genital estão incluídos na categoria de neoplasias raras, e o melanoma vaginal é uma condição ainda mais rara, respondendo por menos de 0,05 a 0,1% das neoplasias genitais. A mortalidade dos melanomas vulvovaginais tem se mantido quase constante nas últimas décadas, e um fator que pode contribuir para a elevada mortalidade é a ausência de diretrizes terapêuticas específicas. Isso torna o diagnóstico do melanoma vaginal bastante desanimador, visto que, normalmente, está associado a um péssimo prognóstico.
Objetivo: Relatar um caso raro de melanoma vaginal atendido em nosso Serviço.
Método: Trata-se do relato do caso de uma paciente atendida no Serviço de Ginecologia e Obstetrícia do Hospital Universitário São Francisco na Providência de Deus – HUSF, situado na cidade de Bragança Paulista, SP. A paciente foi contatada pelos pesquisadores e assinou um Termo de Consentimento Livre e Esclarecido autorizando a realização da pesquisa.
Conclusão: A paciente, de 64 anos, possuía um melanoma vaginal localmente avançado, assim como uma possível metástase pulmonar à distância. O diagnóstico foi realizado com o auxílio de exames de colposcopia, toque vaginal bimanual, estudos anatomopatológicos e imunohistoquímicos. O estadiamento da neoplasia foi detectado por tomografias computadorizadas da pelve, abdome e tórax, assim como por ultrassonografia da região inguinal. A paciente não foi submetida à cirurgia, optando por um tratamento quimioterápico paliativo com dacarbazina e radioterapia.
Usos clínicos do fitoterápico da erva-baleeira (Varronia curassavica jacq.): revisão da literatura
Authors: El Toghlobi Gustavo Saad S. , Arantes Rafael Augusto , Knudsen Beatriz Gianini , Tabach Ricardo , Pereira Marcos Aurélio Almeida , Carvalho Rafael Guzzela de , Ferraz Renato Ribeiro Nogueira , Rodrigues Francisco Sandro Menezes
Published: April 2022

Introdução: A Erva-baleeira (Varronia curassavica Jacq.) é uma planta medicinal e aromática originária do Brasil. A espécie pertence à família Boraginaceae e tem grande relevância econômica devido ao óleo essencial presente em suas folhas. A planta possui importantes ações, como atividade contra o mosquito Aedes aegypti, no entanto, seu principal efeito é anti-inflamatório.
O objetivo desta revisão bibliográfica foi elencar as principais características e efeitos terapêuticos da Varronia curassavica Jacq.
Método: O trabalho foi realizado a partir da busca online, entre junho e agosto de 2020, de artigos científicos publicados em inglês e português entre 2000 e 2020 nas bases de dados de saúde pública “PubMed”, “LILACS” e “SciELO”, onde foram usados os descritores: Cordia; Plantas Medicinais; Fitoterapia. Resultados: Existem registros do uso da erva-baleeira por comunidades tradicionais para tratamento de inflamações, mialgia, artrites, reumatismos, úlceras estomacais e como tônico para contusões. Ela também tem uso citado como cicatrizante em feridas e regiões inflamadas. Popularmente, o uso é feito a partir das folhas em forma de infusão, decocção, pomadas, tinturas, extratos hidroalcoólicos e cataplasmas.
Conclusão: A Erva-baleeira é uma planta medicinal com grande emprego fitoterápico. Seu uso advém principalmente de seu importante efeito anti-inflamatório. Novos estudos sobre as propriedades terapêuticas da Erva-baleeira são necessários, a fim de explorar suas potenciais aplicabilidades clínicas e corroborar cientificamente o uso da erva já popularmente consagrada.
Association of Lipid Profile Ratios to Diabetes Mellitus and Hypertension in an Indian Population
Authors: Atanu Pal  , Arabinda Das
Published: April 2022

Objective: Two lipid ratios (i.e. triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)and HDL-C/total cholesterol (TC)) along with other lipid levels have been considered as importantmeasures of lipid profile and risk for developing coronary disease and type 2 diabetes (T2D). This paperinvestigated independent association between index of lipid measures with T2D and hypertension in astudy of Indian population.Methods: In this prospective study, 162 patients were selected and recorded their socio-economic andphysical characteristics. Each participant was evaluated for lipid levels i.e. TC, TG, HDL-C, low-densitylipoprotein cholesterol (LDL-C) and examined for T2D and hypertension. Multiple logistic regressionwas conducted to find odd ratios (ORs) between lipid measures and ratios with T2D and hypertension.Measures of each lipid and ratio were stratified into quintiles of the distribution and ORs with 95% CIswere estimated for each quintile with lowest quintile as reference. Receiver operating characteristic(ROC) curve was used to discriminate individuals with T2D or hypertension from individuals withoutT2D or hypertension.Results: Patients with T2D and hypertension had higher TG/HDL-C and lower HDL-C/TC(p-value<0.01). T2D and hypertension shared an independent positive correlation with TC, LDL-C,TG, HDL-C/TC and TG/HDL-C. Significant increasing trends in OR for T2D and hypertension wereseen in TG/HDL-C and TG (p-value<0.01). Comparing areas of ROC curves, TG/HDL-C played amore superior role in discriminating between participants with and without T2D, hypertension.Conclusions: TG/HDL-C is strongly associated with T2D and hypertension and is a superior predictorto other lipid measures as a risk marker in this population.
Eosinophilia Induced Acute Interstitial Nephritis: A Case Report
Authors: Lakshya Yadav  , Rajinder Sharma  , Ritu Kaushik  , Riya Dave
Published: April 2022

Introduction: This report presents the case of a patient with tubulointerstitial nephritis (ATIN) due toEosinophilia, situation that has not been reported in India.Case Presentation: A male patient with a history of pulmonary tuberculosis treated with ATT developedacute kidney injury. On admission, no evidence of abnormalities or history to explain the injury wasfound, but he did present tubular acidosis and associated Fanconi syndrome. The kidney injury wastemporarily consistent with ATT use, and a kidney biopsy confirmed ATIN. The drug was suspended,resulting in improved kidney function.Discussion: ATIN as a side effect of rifampin is a scarcely reported disease. The risk of developing thiscondition should be considered when starting and restarting treatments with this medication.Conclusion: ATIN is one of the side effects of tuberculosis treatment. Albeit rare, it should be consideredwhen starting tuberculosis medications.
Effectiveness of Home Isolation in COVID-19 Patients
Authors: Neeti Nayak  , Sidharth Bawa  , Gaurav Thukral
Published: April 2022

Background: The COVID-19 pandemic has created unprecedented disruption for the healthcareindustry, forcing hospitals, organizations fighting infectious diseases, which has led healthcare workerstoreturn up with other ways of delivering medical services while adapting to the new environment.Inadequate quarantine facilities and hospital beds are the major issues facing by the citizens due tosudden increase in cases.Methods: This is statistical and descriptive study that was conducted at Healthcare at Home India Pvt.Ltd, which included patients enrolled for the home isolation programme from the June 2020 to January2021.Conclusion: This study is showing HIP is operative in the home setting for COVID-19 patients is aneffective way of utilising less resources.