bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Hyperkalemia and Hypokalemia with Patient Characteristics and Clinical Outcomes in Japanese Hemodialysis (HD) Patients
Authors: Iwagami Masao , Kanemura Yuka , Morita Naru , Yajima Toshitaka , Fukagawa Masafumi , Kobayashi Shuzo
Published: March 2023

This study aimed to examine the characteristics and clinical outcomes of Japanese hemodialysis patients with dyskalemia. A retrospective study was conducted using a large Japanese hospital group database. Outpatients undergoing thrice-a-week maintenance hemodialysis were stratified into hyperkalemia, hypokalemia, and normokalemia groups based on their pre-dialysis serum potassium (sK) levels during the three-month baseline period. Baseline characteristics of the three groups were described and compared for the following outcomes during follow-up: all-cause mortality, all-cause hospitalization, major adverse cardiovascular events (MACE), cardiac arrest, fatal arrythmia, and death related to arrhythmia. The study included 2846 eligible patients, of which 67% were men with a mean age of 65.65 (SD: 12.63) years. When compared with the normokalemia group (n = 1624, 57.06%), patients in the hypokalemia group (n = 313, 11.00%) were older and suffered from malnutrition, whereas patients in the hyperkalemia group (n = 909, 31.94%) had longer dialysis vintage. The hazard ratios for all-cause mortality and MACE in the hypokalemia group were 1.47 (95% confidence interval [CI], 1.13–1.92) and 1.48 (95% CI, 1.17–1.86), respectively, whereas that of death related to arrhythmia in the hyperkalemia group was 3.11 (95% CI, 1.03–9.33). Thus, dyskalemia in maintenance hemodialysis patients was associated with adverse outcomes, suggesting the importance of optimized sK levels.
The Value of Left Ventricular Mechanical Dyssynchrony and Scar Burden in the Combined Assessment of Factors Associated with Cardiac Resynchronization Therapy Response in Patients with CRT-D
Authors: Atabekov Tariel A. , Khlynin Mikhail S. , Mishkina Anna I. , Batalov Roman E. , Sazonova Svetlana I. , Krivolapov Sergey N. , Saushkin Victor V. , Varlamova Yuliya V. , Zavadovsky Konstantin V. , Popov Sergey V.
Published: March 2023

Background: Cardiac resynchronization therapy (CRT) improves the outcome in patients with heart failure (HF). However, approximately 30% of patients are nonresponsive to CRT. The aim of this study was to determine the role of the left ventricular (LV) mechanical dyssynchrony (MD) and scar burden as predictors of CRT response. Methods: In this study, we included 56 patients with HF and the left bundle-branch block with QRS duration ≥ 150 ms who underwent CRT-D implantation. In addition to a full examination, myocardial perfusion imaging and gated blood-pool single-photon emission computed tomography were performed. Patients were grouped based on the response to CRT assessed via echocardiography (decrease in LV end-systolic volume ≥15% or/and improvement in the LV ejection fraction ≥5%). Results: In total, 45 patients (80.3%) were responders and 11 (19.7%) were nonresponders to CRT. In multivariate logistic regression, LV anterior-wall standard deviation (adjusted odds ratio (OR) 1.5275; 95% confidence interval (CI) 1.1472–2.0340; p = 0.0037), summed rest score (OR 0.7299; 95% CI 0.5627–0.9469; p = 0.0178), and HF nonischemic etiology (OR 20.1425; 95% CI 1.2719–318.9961; p = 0.0331) were the independent predictors of CRT response. Conclusion: Scar burden and MD assessed using cardiac scintigraphy are associated with response to CRT.
Laparoscopic Sleeve Gastrectomy versus Laparoscopic Roux-en-Y Gastric Bypass: An Analysis of Weight Loss Using a Multilevel Mixed-Effects Linear Model
Authors: Pouchucq Camille , Dejardin Olivier , Bouvier Véronique , Lee Bion Adrien , Savey Véronique , Launoy Guy , Menahem Benjamin , Alves Arnaud
Published: March 2023

Background: Regarding weight loss outcomes, the results published after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y (LRYGB) are conflicting. At this time, no clear evidence exists that outcomes from LSG are similar to those for LRYGB. The main objective of this study was to compare the percent of total weight loss (%TWL) between LRYGB and LSG over the first 2 years using a multilevel mixed-effects linear regression. Methods: Data were collected from a prospectively maintained database of patients who underwent primary laparoscopic bariatric surgery from January 2016 to December 2017 at a French accredited bariatric center. The medical records of 435 consecutive patients were analyzed. %TWL was calculated at each follow-up surgical consultation and used as a repeated outcome variable in our models to assess the long-term %TWL. Due to this hierarchical structure of the data (%TWL at each visit = level 1) within patients (level 2), a multilevel linear regression adjusted for age, sex, preoperative BMI and comorbidities was used. Results: Among the medical records of 435 consecutive patients included, 266 patients underwent LRYGB and 169 underwent LSG. The average %TWL at 2 years was 31.7% for the LRYGB group and 25.8% for the LSG group. The final multivariate model showed that, compared with LRYGB, LSG was associated with a decreased %TWL at over 2 years of follow-up (β: −4.01; CI95%: −5.47 à −2.54; p ≤ 0.001). Conclusion: This observational study suggests that compared with LRYGB, LSG was associated with a decreased %TWL at 2 years using a multilevel model. Further studies are required to confirm the results observed with this statistical model.
Comparison between Target Sample Check Illuminator and White Light Observation in Discriminating the Presence of Target Specimen for Endoscopic Ultrasound-Guided Fine Needle Aspiration Sample
Authors: Koda Hiroki , Matsumoto Kazuya , Kawata Soichiro , Takeda Yohei , Onoyama Takumi , Seki Yuta , Sakamoto Yuri , Shimosaka Takuya , Hamamoto Wataru , Yamashita Taro , Kurumi Hiroki , Yamaguchi Naoyuki , Noma Hisashi , Isomoto Hajime
Published: March 2023

Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an essential endoscopic tissue sampling method for diagnosing pancreatobiliary diseases; however, determining the presence of target specimens mixed in the blood by conventional observation is challenging due to the small size of the obtained sample. This study investigated the usefulness of a target sample check illuminator (TSCI) that emits a specific wavelength of light to determine the presence of target specimens. Twenty-seven patients who underwent EUS-FNA at our hospital were included. Conventional white light observation was performed for the collected samples, followed by TSCI; six people evaluated the presence of the target specimen on a 5-point scale. The target specimen discrimination score using TSCI (median: 5) was significantly higher than that using conventional white light observation (median: 1) (p < 0.001). No significant difference was observed in the discrimination score between the evaluator (novice vs. expert, p = 0.162) and puncture needle (22G vs. 25G, p = 0.196). The discriminability of TSCI in the samples obtained using EUS-FNA was significantly higher than that of conventional observation. TSCI does not depend on the evaluator or puncture needle for the identification of the target specimen; hence, it can provide a good pathological specimen and may contribute to the improvement of the diagnostic ability.
A Comparison between the Results from Linear Analysis and Nonlinear Analysis in the Context of Simulation of Biological Materials
Authors: P Kirana Kumara
Published: March 2023

Surgical simulations require fast and accurate simulation of biological materials. In general, linear analysis is faster but less accurate, whereas nonlinear analysis is more accurate but slower. In this work, a kidney is simulated by using both linear analysis and nonlinear analysis, the results are compared, and the errors quantified. The software package ANSYS is used for the purpose. This work presents detailed results and comparison of linear and nonlinear analysis in the context of simulation of a human kidney, which is not easily found in the literature. The results reinforce the idea that linear analysis is a useful tool for simulating biological materials when solution time is as much important as the accuracy of solutions.
Experimental Research on the Dynamic Stability of Internal Turning Tools for Long Overhangs
Authors: da Silva Wallyson Thomas Alves , Peterka Jozef , Vopat Tomas
Published: March 2023

The roughness origin of machined surfaces is caused by the following physical causes: the copying of the shape and the roughness of the cutting part of the tool into the workpiece, the existence of vibration of the tool, and the existence of the build-up edge (BUE) on the cutting edge. The current work aims to analyze the vibration amplitude of tools. The roughness of the machined surfaces was observed on hardened steel workpieces. Internal turning technology was used, and we used several different boring bars (steel; carbide; tuned mass damper—TMD; impact damper—ID) and an internal turning operation using CBN inserts. We revealed the tool’s slenderness coefficient (TSC) values for stable cutting operations. For the steel holder, the value is TSC ≤ 4.25; for the carbide holder, the value is TSC ≤ 5.5; for the TMD holder, the value is 4.5 ≤ TSC ≤ 7.75; and for the ID holder, the value is TSC ≤ 8. The surface’s roughness was practically unchanged within the limits of stable machining. However, if the tools exceed the presented stable limits, vibration and roughness parameters deteriorate significantly; an example parameter (Ra) deteriorated from 0.350 μm to 1.832 μm.
Insight into Hydrodynamic Damping of a Segmented Barge Using Numerical Free-Decay Tests
Authors: Bašić Josip , Degiuli Nastia , Malenica Šime
Published: March 2023

Natural vibrations of a segmented and a monohull barge are analysed to compare influences of hydrodynamic damping on the dynamic responses of two different models. The influence of water flow around and between barge segments on hydrodynamic damping was investigated by simulating free-decay tests using a URANS method. Fluid forces were fed into the modal solver, which allows for efficient deformation of the structure without full resolution of structural equations. Verification of the coupled solver was performed by reproducing the model experiments of a segmented barge. Comparison of segmented and monohull results clarified the impact of gaps between barge segments, i.e., how the energy dissipates because of large pressure gradients within and around gaps, and additional free-surface movement. This insight of higher damping should be taken into account for model tests of segmented floating structures, such as wave-energy-converting systems.
Mediator Subunit Med15 Regulates Cell Morphology and Mating in Candida lusitaniae
Authors: Sabra Ayman , Biteau Nicolas , Dupuy Jean-William , Klopp Christophe , Noël Thierry , Dementhon Karine
Published: March 2023

Candida lusitaniae is an emerging opportunistic pathogenic yeast capable of shifting from yeast to pseudohyphae form, and it is one of the few Candida species with the ability to reproduce sexually. In this study, we showed that a dpp3Δ mutant, inactivated for a putative pyrophosphatase, is impaired in cell separation, pseudohyphal growth and mating. The defective phenotypes were not restored after the reconstruction of a wild-type DPP3 locus, reinforcing the hypothesis of the presence of an additional mutation that we suspected in our previous study. Genetic crosses and genome sequencing identified an additional mutation in MED15, encoding a subunit of the mediator complex that functions as a general transcriptional co-activator in Eukaryotes. We confirmed that inactivation of MED15 was responsible for the defective phenotypes by rescuing the dpp3Δ mutant with a wild-type copy of MED15 and constructing a med15Δ knockout mutant that mimics the phenotypes of dpp3Δ in vitro. Proteomic analyses revealed the biological processes under the control of Med15 and involved in hyphal growth, cell separation and mating. This is the first description of the functions of MED15 in the regulation of hyphal growth, cell separation and mating, and the pathways involved in C. lusitaniae.
Mucorales and Mucormycosis: Recent Insights and Future Prospects
Authors: Tahiri Ghizlane , Lax Carlos , Cánovas-Márquez José Tomás , Carrillo-Marín Pablo , Sanchis Marta , Navarro Eusebio , Garre Victoriano , Nicolás Francisco Esteban
Published: March 2023

The classification of Mucorales encompasses a collection of basal fungi that have traditionally demonstrated an aversion to modern genetic manipulation techniques. This aversion led to a scarcity of knowledge regarding their biology compared to other fungal groups. However, the emergence of mucormycosis, a fungal disease caused by Mucorales, has attracted the attention of the clinical field, mainly because available therapies are ineffective for decreasing the fatal outcome associated with the disease. This revitalized curiosity about Mucorales and mucormycosis, also encouraged by the recent COVID-19 pandemic, has spurred a significant and productive effort to uncover their mysteries in recent years. Here, we elaborate on the most remarkable breakthroughs related to the recently discovered genetic advances in Mucorales and mucormycosis. The utilization of a few genetic study models has enabled the identification of virulence factors in Mucorales that were previously described in other pathogens. More notably, recent investigations have identified novel genes and mechanisms controlling the pathogenic potential of Mucorales and their interactions with the host, providing fresh avenues to devise new strategies against mucormycosis. Finally, new study models are allowing virulence studies that were previously hampered in Mucorales, predicting a prolific future for the field.
The Construction of Peacebuilding Narratives in ‘Media Talk’—A Methodological Discussion
Authors: Ortiz dos Santos Fabíola
Published: March 2023

How are narratives around peace and conflict constructed in radio? This paper offers a detailed discussion of a framework of analysis of media narratives. It examines how perceptions of peacebuilding are constructed and aired in radiophonic debates. It deals with methodological questions and carries out an interpretative analysis of narratives in ‘media talk’, here defined as a broadcast output in the form of ‘talking’. The narrative analysis is composed of four dimensions: thematic, structural, actor and agency levels. What started as an effort to study a political debate in the Central African Republic from a radio station named Ndeke Luka, evolved into an in-depth reflection of how competing, clashing and counter peacebuilding narratives can take form. One particular transcript of a radio programme is hereby used to exemplify and illustrate how this analytical framework is operationalised. It is not intended, though, to offer any generalisation claim as this study is a work in progress. While interrogating the ways peacebuilding narratives in ‘media talk’ can be detected, this paper goes beyond the sharing of a particular case. This model makes it possible to apprehend the nuances of ‘media talk’ as a contesting and disputing space for diverse narratives. As a point of departure, it claims that the ideas of peacebuildings (in plural) relate to experiential practices. Research in ‘media talk’ constitutes a relevant arena for mapping emerging narratives of conflict and peace.
A Comprehensive Approach through Robust Regression and Gaussian/Mixed-Markov Graphical Models on the Example of Maritime Transportation Accidents: Evidence from a Listed-in-NYSE Shipping Company
Authors: Zampeta Vicky , Chondrokoukis Gregory
Published: March 2023

The main objective of this article is to determine the internal factors of maritime transportation accidents using a comprehensive approach through robust regression and Gaussian/mixed-Markov graphical models. Globally, this could be a strong incentive for the employees to negotiate higher compensation and for the insurance companies to impose higher premiums to cover the risk for these kinds of accidents. The article uses a dataset consisting of 166 real cases (human injuries) in the period 2014–2022 in different ships owned by a shipping company indexed in the New York Stock Exchange. The results of the study support the hypotheses as have been set in the article, connecting the internal factors with the injuries of any type. The practical implementation of the study is its ability to be used by policy makers in shipping to compensate employees depending on the risk of their work on board and at the same time to calculate the insurance premiums in a more accurate way. The originality of the research lies in the fact that this is a unique study in maritime transportation related to human accidents and not on ship or cargo casualties. The idea came from the results of another study conducted on a bibliometric analysis of the factors related to maritime transportation accidents. The findings of the current study can provide valuable insights to stakeholders and shipping planners in formulating effective policies for better wage packages and insurance premiums.
Evaluation of Internal Audit Standards as a Foundation for Carrying out and Promoting a Wide Variety of Value-Added Tasks-Evidence from Emerging Market
Authors: Shaban Osama Samih , Barakat Abdallah Izzat
Published: March 2023

This research paper aims to evaluate the effectiveness of internal audit standards as a foundation for carrying out and promoting a wide variety of value-added tasks in emerging markets. Three Jordanian telecommunications firms were the subject of the study. In each firm, the non-executive directors, who serve on the Audit Committee, also received a questionnaire that was designed for this objective. In total 85 questionnaires were accepted and analyzed using traditional statistical methods such as descriptive statistics, arithmetic means, standard deviations, and percentages, and resolution data were examined using the statistical application SPSS. According to the annual report for the year 2021, telecommunication businesses generally followed IIA International Internal Audit Standards. Application Standards were employed to a high degree in second place, after Attribute Standards, which were used primarily in the first place. In those firms, performance standards were not used. The study also found that this form of application is moderately constrained by a few challenges and barriers. The study recommended that these organizations broaden the scope and scale of internal auditing standards, particularly performance requirements. Finally, the generalization of research findings is limited because the study is limited to three Jordanian telecommunication companies.
Exploring the Onset of Phonetic Drift in Voice Onset Time Perception
Authors: Kellogg Jackson , Chang Charles B.
Published: March 2023

Recent exposure to a second or foreign language (FL) can influence production and/or perception in the first language (L1), a phenomenon referred to as phonetic drift. The smallest amount of FL exposure shown to effect drift in perception is 1.5 h. The present study examined L1 perception at earlier timepoints of FL exposure, to determine whether the phonetic system is able to resist FL influence at an incipient stage. In a longitudinal pre-test/post-test design, L1 English listeners were exposed to Tagalog under different conditions varying in attention directed to the voice onset time (VOT) plosive contrast in the FL; they then completed an identification task on L1 tokens from VOT continua. In every condition, the likelihood of “voiceless” identifications decreased. This change indicates a shift towards a longer VOT crossover point between “voiced” and “voiceless”, consistent with dissimilatory drift in perception. Listeners in a control condition, however, displayed a similar, albeit less lasting, change in L1 judgments, suggesting that the change arose partly from a task effect. We conclude by discussing directions for future research on phonetic drift in perception.
Indexing Resilience to Heat and Drought Stress in the Wild Relatives of Rapeseed-Mustard
Authors: Kashyap Anamika , Kumari Sujata , Garg Pooja , Kushwaha Ranjeet , Tripathi Shikha , Sharma Jyoti , Gupta Navin C. , Kumar Rajeev Ranjan , Yadav Rashmi , Vishwakarma Harinder , Rana Jai Chand , Bhattacharya Ramcharan , Rao Mahesh
Published: March 2023

Wild species are weedy relatives and progenitors of cultivated crops, usually maintained in their centres of origin. They are rich sources of diversity as they possess many agriculturally important traits. In this study, we analysed 25 wild species and 5 U triangle species of Brassica for their potential tolerance against heat and drought stress during germination and in order to examine the early seedling stage. We identified the germplasms based on the mean membership function value (MFV), which was calculated from the tolerance index of shoot length, root length, and biochemical analysis. The study revealed that B. napus (GSC-6) could withstand high temperatures and drought. Other genotypes that were tolerant to the impact of heat stress were B. tournefortii (RBT 2002), D. gomez-campoi, B. tournefortii (Rawa), L. sativum, and B. carinata (PC-6). C. sativa resisted drought but did not perform well when subjected to high temperatures. Tolerance to drought was observed in B. fruticulosa (Spain), B. tournefortii (RBT 2003), C. bursa-pastoris (late), D. muralis, C. abyssinica (EC694145), C. abyssinica (EC400058) and B. juncea (Pusa Jaikisan). This investigation contributes to germplasm characterization and the identification of the potential source of abiotic stress tolerance in the Brassica breeding programme. These identified genotypes can be potential sources for transferring the gene(s)/genomic regions that determine tolerance to the elite cultivars.
Effects of an Amphiphilic Micelle of Diblock Copolymer on Water Adsorption of Cement Paste
Authors: Dong Lei , Meng Fei , Feng Pan , Ran Qianping , Pan Chonggen , He Jianming
Published: March 2023

To reduce the inhibiting effects of polystyrene-based emulsion on the hydration process and strength development of cementitious materials, an amphiphilic diblock copolymer polystyrene-block-poly(acrylic acid) (PS-b-PAA) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and demonstrated in cement paste system for improving the resistance to water absorption without significantly reducing 28-day compressive strength. Firstly, the dissolved PS-b-PAA was added into water, and it quickly self-assembled into amphiphilic 80 nm-sized micelles with hydrophobic polystyrene-based core and hydrophilic poly(acrylic acid)-based shell. The improved dispersion compared to that of polystyrene emulsion may minimize the inhibiting effects on strength development, as the effects of PS-b-PAA micelle as hydrophobic admixtures on rheological properties, compressive strength, water absorption, hydration process, and pore structure of 28-day cement pastes were subsequently investigated. In comparison with the control sample, the saturated water absorption amount of cement pastes with 0.4% PS-b-PAA was reduced by 20%, and the 28-day compressive strength was merely reduced by 2.5%. Besides, the significantly increased hydrophobicity instead of slightly decreased porosity of cement paste with PS-b-PAA may contribute more to the reduced water adsorption characteristics. The study based on prepared PS-b-PAA micelle suggested a promising alternative strategy for fabricating polystyrene-modified concrete with reduced water absorption and unaffected compressive strength.
Deterring Sellers’ Cheap Talk Actions via Online Rating Schemes
Authors: Yang Meijian , Xia Enjun , Yang Yang
Published: March 2023

This paper develops a two-period game theoretic model to investigate a seller’s quality claims in a cheap-talk setting. In this model, consumers are reference-dependent with respect to product quality, and consumers who have purchased items can share their quality assessments via online ratings; additionally, consumers may be naive or experienced: naive consumers simply believe the quality claims and quality assessments, whereas experienced consumers can accordingly make rational quality inferences. We find that, in the scenario with only naive consumers, when the reference effect is weak, the seller will always claim the highest quality; when the reference effect is strong, the low-quality seller will claim the highest quality, whereas the high-quality seller will understate its products’ quality. In the scenario with only experienced consumers, the seller will claim some moderate quality levels. In the scenario with both types of consumers, in period one, the low-quality seller will always claim some moderate quality levels to serve both types of consumers, whereas the high-quality seller will claim the highest quality when the reference effect is extremely weak and thus serve only naive consumers, or it will adopt truth-telling otherwise; in period two, the low-quality seller will charge a higher price to serve only experienced consumers, whereas the high-quality seller will charge a lower price to serve both types of consumers.
Prediction of Coal Dilatancy Point Using Acoustic Emission Characteristics: Insight Experimental and Artificial Intelligence Approaches
Authors: Ali Muhammad , Khan Naseer Muhammad , Gao Qiangqiang , Cao Kewang , Jahed Armaghani Danial , Alarifi Saad S. , Rehman Hafeezur , Jiskani Izhar Mithal
Published: March 2023

This research offers a combination of experimental and artificial approaches to estimate the dilatancy point under different coal conditions and develop an early warning system. The effect of water content on dilatancy point was investigated under uniaxial loading in three distinct states of coal: dry, natural, and water-saturated. Results showed that the stiffness-stress curve of coal in different states was affected differently at various stages of the process. Crack closure stages and the propagation of unstable cracks were accelerated by water. However, the water slowed the elastic deformation and the propagation of stable cracks. The peak strength, dilatancy stress, elastic modulus, and peak stress of natural and water-saturated coal were less than those of dry. An index that determines the dilatancy point was derived from the absolute strain energy rate. It was discovered that the crack initiation point and dilatancy point decreased with the increase in acoustic emission (AE) count. AE counts were utilized in artificial neural networks, random forest, and k-nearest neighbor approaches for predicting the dilatancy point. A comparison of the evaluation index revealed that artificial neural networks prediction was superior to others. The findings of this study may be valuable for predicting early failures in rock engineering.
(α − ψ) Meir–Keeler Contractions in Bipolar Metric Spaces
Authors: Kumar Manoj , Kumar Pankaj , Ramaswamy Rajagopalan , Abdelnaby Ola A. Ashour , Elsonbaty Amr , Radenović Stojan
Published: March 2023

In this paper, we introduce the new notion of contravariant (α−ψ) Meir–Keeler contractive mappings by defining α-orbital admissible mappings and covariant Meir–Keeler contraction in bipolar metric spaces. We prove fixed point theorems for these contractions and also provide some corollaries of main results. An example is also be given in support of our main result. In the end, we also solve an integral equation using our result.
Innovation in Brazilian Industries: Analysis of Management Practices Using Fuzzy TOPSIS
Authors: Pompilio Giulia Giacomello , Sigahi Tiago F. A. C. , Rampasso Izabela Simon , Moraes Gustavo Hermínio Salati Marcondes de , Ávila Lucas Veiga , Leal Filho Walter , Anholon Rosley
Published: March 2023

This study examined the practices of innovation management used by Brazilian industries. A survey was carried out with specialists that assessed 27 practices (PR) proposed by ISO 56002, considering two types of firms: small and medium-sized industries (SMI) and large industries (LI). The methodological approach included Hierarchical Cluster Analysis to identify the similarities between the specialists and define levels of specialists, as well as Fuzzy TOPSIS and frequency and sensitivity analyses to examine their responses. PR1 (analysis of internal and external issues that impact innovation management) was deemed the best practice for LIs, whereas PR10 (adequate assessment of potential partnerships) was best evaluated for SMIs. The PR27 (periodic audits to identify opportunities for improvement) received the lowest rating from both LIs and SMIs. In general, SMIs in the Brazilian context have more severe deficiencies in terms of applying innovation management practices than LIs. A broad overview of the innovation practices adopted in the Brazilian industrial scenario is provided. The study’s findings may assist managers and policymakers to develop initiatives and actions to improve the capacity of Brazilian industries to innovate. This research can also support future studies aimed at better understanding specific practices related to the topic.
Performance Analysis of Multi-Objective Simulated Annealing Based on Decomposition
Authors: Vargas-Martínez Manuel , Rangel-Valdez Nelson , Fernández Eduardo , Gómez-Santillán Claudia , Morales-Rodríguez María Lucila
Published: March 2023

Simulated annealing is a metaheuristic that balances exploration and exploitation to solve global optimization problems. However, to deal with multi- and many-objective optimization problems, this balance needs to be improved due to diverse factors such as the number of objectives. To deal with this issue, this work proposes MOSA/D, a hybrid framework for multi-objective simulated annealing based on decomposition and evolutionary perturbation functions. According to the literature, the decomposition strategy allows diversity in a population while evolutionary perturbations add convergence toward the Pareto front; however, a question should be asked: What is the effect of such components when included as part of a multi-objective simulated annealing design? Hence, this work studies the performance of the MOSA/D framework considering in its implementation two widely used perturbation operators: classical genetic operators and differential evolution. The proposed algorithms are MOSA/D-CGO, based on classical genetic operators, and MOSA/D-DE, based on differential evolution operators. The main contribution of this work is the performance analysis of MOSA/D using both perturbation operators and identifying the one most suitable for the framework. The approaches were tested using DTLZ on two and three objectives and CEC2009 benchmarks on two, three, five, and ten objectives; the performance analysis considered diversity and convergence measured through the hypervolume (HV) and inverted generational distance (IGD) indicators. The results pointed out that there is a promising improvement in performance in favor of MOSA/D-DE.
Selenium Status and Oxidative Stress in SARS-CoV-2 Patients
Authors: Šķesters Andrejs , Lece Anna , Kustovs Dmitrijs , Zolovs Maksims
Published: March 2023

Background and Objectives: Insufficient intake of essential micronutrient selenium (Se) increases the susceptibility to diseases associated with oxidative stress. The study aim was to assess Se status and oxidative stress in COVID-19 patients depending on severity of the disease. Materials and Methods: Blood plasma of 80 post-COVID-19 disease patients and 40 acutely ill patients were investigated. Concentration of Se was detected by a fluorometric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P (Sepp1), malondialdehyde (MDA), and 4-hydroxynonenal (4-HNE) and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results demonstrated that Se and Sepp1 concentration in acute patients were significantly (p < 0.05 for Se and p < 0.001 for Sepp1) decreased compared with post-COVID-19 disease patients. However, in post-COVID-19 disease patients, Se values were close to the low limit of the norm for the European population. 4-HNE adducts concentration as a marker of lipid peroxidation was significantly increased in the acute patients group compared to the recovery group (p < 0.001). Conclusions: COVID-19 pathology is characterized by the induction of oxidative stress and suppression of antioxidant defenses during the acute phase. Lower levels of Se and Sepp1 and higher levels of reactive oxygen species reflect this imbalance, highlighting the role of oxidative stress in the disease’s pathogenesis.
Congenital Proximal Radioulnar Synostosis in an Elite Athlete–Case Report
Authors: Chandoga Ilja , Petrovič Róbert , Varga Ivan , Šteňo Boris , Šteňová Emὄke
Published: March 2023

Background and Objectives: Proximal radioulnar synostosis (PRUS) is the most frequent congenital forearm disorder, although the prevalence in the general population is rare with a few hundred cases reported. Pfeiffer, Poland, Holt–Oram, and other serious congenital syndromes contain this abnormality. Non-syndromic cases with isolated PRUS very often exhibit as SMAD6, NOG genes variants, or sex chromosome aneuploidy. A subgroup of patients with haematological abnormalities presents with HOXA11 or MECOM genes variants. Case report: We present a non-syndromic adult elite ice-hockey player with unilateral proximal radioulnar synostosis of the left forearm. In early childhood he was able to handle the hockey stick only as a right-handed player and the diagnosis was set later at the age of 8 years due to lack of supination. Cleary–Omer Type III PRUS was found on x-ray with radial head hypoplasia and mild osteophytic degenerative changes of humeroulnar joint. Since the condition had minimal impact on sports activities, surgical intervention was not considered. The player continued his ice-hockey career at the top level and joined a national team for top tournaments. Upper extremity function assessment with questionnaires and physical testing resulted in minimal impairment. The most compromised tool was the Failla score with 10 points from a total of 15. Genetic testing with Sanger sequencing revealed no significant pathogenic variant in SMAD6, NOG, and GDP5 genes. No potentially pathogenic copy number variants were detected by array-based comparative genomic hybridization. Conclusions: In the reported case, the ability of an athlete to deal with an anatomic variant limiting the forearm supination is demonstrated. Nowadays, a comprehensive approach to rule out more complex musculoskeletal impairment and family burden is made possible by evolving genetics.
Time Synchronization Sensitivity in SV-based PMU Consistency Assessment
Authors: Agustoni Marco , Castello Paolo , Frigo Guglielmo , Gallus Giacomo
Published: March 2023

Modern power systems are rapidly transitioning towards a fully digital substation paradigm. Based on the IEC 61850, a common communication protocol between the different intelligent electronic devices (IEDs) promises a significant enhancement in terms of efficiency and interoperability. In this context, synchronization represents a crucial aspect as it allows us to rigorously compare measurements taken at the same time in different locations. In this paper, we consider a measurement chain for synchrophasor estimation based on digital inputs: an instrument transformer, a stand-alone merging unit (SAMU) and a phasor measurement unit (PMU). Both the SAMU and the PMU are equipped with independent synchronization sources. In case the SAMU loses its synchronization, the final measurement result would be considered invalid until a complete restoration of the SAMU synchronization status. In view of a longer continuity of operation, this paper proposes an alternative approach to evaluate the PMU Time Quality in real-time. This approach allows for continuing crucial monitoring and control operations, such as state estimation and fault detection, even in the presence of temporary loss of synchronization. A characterization, in both simulated and experimental conditions, proves the potential and reliability of the proposed approach. In the considered test case, the come-back within a sufficient time quality is correctly detected in less than 200 s, while waiting for the full restoration of the SAMU time reference would cost several minutes.
Special Issue “Bacteriophage Genomics”: Editorial
Authors: Babkin Igor V. , Tikunova Nina V.
Published: March 2023

Virus genomics as a separate branch of biology has emerged relatively recently [...]
Physical Function Tests Are Potential Tools to Identify Low Physical Resilience in Women after Breast Cancer Treatment
Authors: Martins Fernanda Maria , de Oliveira Anselmo Alves , Oliveira-Júnior Gersiel , Carneiro Marcelo A. S. , de Souza Luís Ronan Marquez Ferreira , Lara Vitor Carvalho , Nomelini Rosekeila Simões , Assumpção Cláudio Oliveira , Souza Markus Vinícius Campos , Orsatti Fábio Lera
Published: March 2023

Background: This study sought to investigate whether different physical function tests (objective measures of physical performance) may identify a low physical resilience in breast cancer survivors (BCS). Methods: This analytical cross-sectional study evaluated 146 BCS and 69 age-matched women without breast cancer history. The different times after the end of treatment were used as criteria for group division. Participants were divided into four groups: control (CT: n = 69–women without breast cancer history); <1.0 years after the end of treatment (<1 YAT: n = 60); 1–3.9 years after the end of treatment (1–3.9 YAT: n = 45); and ≥4 years after the end of treatment (>4 YAT: n = 41). Physical function was evaluated by 4 m walk test (4-MWT), five-times-sit-to-stand test (FTSST), timed up and go test (TUG), and short physical performance battery (SPPB). Age, menopausal status, smoking, number of medications, level of physical activity, body mass index, and muscle strength were used as confounding variables in ANCOVA. Results: All groups that underwent cancer treatment (<1 YAT, 1–3.9 YAT and ≥4 YAT) had lower physical performance (p < 0.001) identified by 4 MWT, TUG, and FTSST when compared to the CT group. For the SPPB, the <1 YAT and ≥4 YAT groups had lower performance (p = 0.005) when compared to the CT. Conclusions: The different physical function tests can be used to identify a low physical resilience in BCS.
Fe-Ce/Layered Double Hydroxide Heterostructures and Their Derived Oxides: Electrochemical Characterization and Light-Driven Catalysis for the Degradation of Phenol from Water
Authors: Mureseanu Mihaela , Cioatera Nicoleta , Carja Gabriela
Published: March 2023

Fe-Ce/layered double hydroxides (LDHs) were synthesized via a facile route by exploiting the “structural memory” of the LDH when the calcined MgAlLDH and ZnAlLDH were reconstructed in the aqueous solutions of FeSO4/Ce(SO4)2. XRD analysis shows the formation of heterostructured catalysts that entangle the structural characteristics of the LDHs with those of Fe2O3 and CeO2. Furthermore, X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, TG/DTG, SEM/EDX and TEM results reveal a complex morphology defined by the large nano/microplates of the reconstructed LDHs that are tightly covered with nanoparticles of Fe2O3 and CeO2. Calcination at 850 °C promoted the formation of highly crystallized mixed oxides of Fe2O3/CeO2/ZnO and spinels. The photo-electrochemical behavior of Fe-Ce/LDHs and their derived oxides was studied in a three-electrode photo-electrochemical cell, using linear sweep voltammetry (LSV), Mott–Schottky (M-S) analysis and photo-electrochemical impedance spectroscopy (PEIS) measurements, in dark or under illumination. When tested as novel catalysts for the degradation of phenol from aqueous solutions, the light-driven catalytic heterojunctions of Fe-Ce/LDH and their derived oxides reveal their capabilities to efficiently remove phenol from water, under both UV and solar irradiation.
Cryptococcal Meningitis: Differences between Patients with and without HIV-Infection
Authors: Teekaput Chutithep , Yasri Saowaluck , Chaiwarith Romanee
Published: March 2023

Background: Cryptococcal meningitis is one of the most devastating infections, particularly in HIV-infected individuals. The increased use of immunosuppressants led to an increase in the incidence of cryptococcosis in HIV-uninfected individuals. This study aimed to compare the characteristics between groups. Methods: This retrospective cohort study was conducted from 2011 to 2021 in northern Thailand. Individuals diagnosed with cryptococcal meningitis aged ≥15 years were enrolled onto the study. Results: Out of 147 patients, 101 were individuals infected with HIV and 46 were non-infected. Factors associated with being infected with HIV included age < 45 years (OR 8.70, 95% CI 1.78–42.62), white blood cells < 5000 cells/cu.mm. (OR 7.18, 95% CI 1.45–35.61), and presence of fungemia (OR 5.86, 95% CI 1.17–42.62). Overall, the mortality rate was 24% (18% in HIV-infected vs. 37% in HIV-uninfected individuals, p-value = 0.020). Factors associated with mortality included concurrent pneumocystis pneumonia (HR 5.44, 95% CI 1.55–19.15), presence of alteration of consciousness (HR 2.94, 95% CI 1.42–6.10), infection caused by members of C. gattii species complex (HR 4.19, 95% CI 1.39–12.62), and anemia (HR 3.17, 95% CI 1.17–8.59). Conclusions: Clinical manifestations of cryptococcal meningitis differed between patients with and without HIV-infection in some aspects. Increasing awareness in physicians of this disease in HIV-uninfected individuals may prompt earlier diagnosis and timely treatment.
On the Subjective Value of Life
Authors: Arandjelović Ognjen
Published: March 2023

Claims (or the implicit assumption) of the inherent worth of life are pervasive and remain virtually unchallenged. I have already argued that these outright moral dictates are thinly veiled vestiges of theological ethics which, following the removal of their theological foundations, remain little more than nebulous claims supported only by fear of the consequences of a challenge. In my previous work, I rejected an a priori claim of an objective life’s worth, which is the worth that we should assign to others’ lives, and elucidated a principled framework that gives rise to the said worth immediately, as a consequence of the experiences of its sentient environment. Herein, I address the complementary question of the value of one’s own life, which is the subjective value of life and, thus, Camus’s (in)famous view that “there is but one truly serious philosophical problem, and that is suicide”. As before, I rejected the inherency of a life’s worth, showing it to be contradictio in adjecto, and instead show how this worth too can in large part be seen to emerge from sentient experiences of the subject. Many of these are innately linked to experiences of other sentient beings as objects, thus erecting a framework that is both principled and thoroughly humane with Schopenhauer’s ‘loving kindness’ running through it. Practically, my framework illuminates an understanding of suicide as a real-world phenomenon, helping those who remain living to understand a deceased one’s decision, and paving the way to answering questions, such as when there should be an attempt to prevent suicide, and what means of suicide prevention are ethically permissible.
Statistical Tool Size Study for Computer-Controlled Optical Surfacing
Authors: Pullen Weslin C. , Wang Tianyi , Choi Heejoo , Ke Xiaolong , Negi Vipender S. , Huang Lei , Idir Mourad , Kim Daewook
Published: March 2023

Over the past few decades, computer-controlled optical surfacing (CCOS) systems have become more deterministic. A target surface profile can be predictably achieved with a combination of tools of different sizes. However, deciding the optimal set of tool sizes that will achieve the target residual error in the shortest run time is difficult, and no general guidance has been proposed in the literature. In this paper, we present a computer-assisted study on choosing the proper tool size for a given surface error map. First, we propose that the characteristic frequency ratio (CFR) can be used as a general measure of the correction capability of a tool over a surface map. Second, the performance of different CFRs is quantitatively studied with a computer simulation by applying them to guide the tool size selection for polishing a large number of randomly generated surface maps with similar initial spatial frequencies and root mean square errors. Finally, we find that CFR = 0.75 achieves the most stable trade-off between the total run time and the number of iterations and thus can be used as a general criterion in tool size selection for CCOS processes. To the best of our knowledge, the CFR is the first criterion that ties tool size selection to overall efficiency.
Microbial Biopolymers: Trends in Synthesis, Modification, and Applications
Authors: Bhatia Shashi Kant
Published: March 2023

Microbes can act as a factory for the conversion of a variety of carbon and nitrogen sources into diverse kinds of intracellular and extracellular biopolymers, including polyhydroxyalkanoates (PHA) and exopolysaccharides (EPS), under different stress conditions [...]
Verification of the Japanese Version of Greene’s Moral Dilemma Task’s Validity and Reliability
Authors: Takimoto Yoshiyuki , Yasumura Akira
Published: March 2023

The moral dilemma task developed by Greene et al., which comprises personal and impersonal moral dilemmas, is useful for clarifying people’s moral judgments. This study develops and validates a Japanese version of this questionnaire. Ten new questions were added to the Japanese version using back-translation, and its internal validity was tested. A second survey was conducted among the same participants one month after the first survey (n = 231). The intraclass correlation coefficient through retesting was found to be 0.781. Test-retest, internal consistency, and criterion-related validity were confirmed by retesting the Japanese version of the moral dilemma task. Moral judgments differed in gender, with women and men tending to be more utilitarian in situations where emotions were less and more likely to be involved, respectively. The association between age and deontological moral judgments was also observed.