bluuebunny/crossref_metadata_2025 huggingface dataset:
NUGGET BERBASIS SUSU KERBAU DENGAN PENAMBAHAN IKAN BILIH (Mystacoleucus padangensis) SEBAGAI MAKANAN TAMBAHAN TUMBUH KEMBANG BALITA
Authors: Yahdillah Honey , Diana Fivi Melva , Helmizar Helmizar
Published: June 2024

Ikan bilih berpotensi yang diolah menjadi salah satu produk olahan pangan dapat berfungsi sebagai penunjang dalam penanganan penurunan stunting pada balita. Penelitian ini bertujuan untuk mengembangkan produk Nugget susu kerbau dengan penambahan ikan bilih (Mystacoleucus padangensis) terhadap uji organoleptik dan kandungan zat gizi sebagai makanan tambahan untuk mendukung tumbuh kembang balita (usia 1-3 tahun). Metode penelitian ini dilakukan secara true experiment yang dilakukan di laboratorium berupa percobaan penambahan ikan bilih dalam pembuatan produk Nugget susu kerbau. Produk dibuat dengan 4 perlakuan yang terdiri dari F0 (formula standar), F1, F2, dan F3 dengan penambahan tepung ikan bilih berturut-turut sebesar 0%, 5%, 15%, dan 25%. Percobaan dilakukan dengan dua kali ulangan menggunakan Rancangan Acak Lengkap (RAL). Uji organoleptik dilakukan menggunakan lembar pengujian berdasarkan SNI 01-2346- 2006 tentang petunjuk pengujian organoleptik atau sensori yang dimodifikasi sesuai kebutuhan penelitian dan melibatkan 25 orang panelis agak terlatih. Analisis data dilakukan menggunakan uji Kruskal Wallis dengan taraf pengujian 5% dan dilanjutkan dengan uji Mann Whitney sebagai uji lanjut. Hasil penelitian menyatakan bahwa berdasarkan uji organoleptik, formula yang paling disukai oleh panelis adalah F1 dengan karakteristik mutu warna kuning cerah, gurih, harum, dan tekstur empuk. Tidak ada perbedaan nyata antara keempat formula (p-value >0,05). Berdasarkan uji kandungan zat gizi, F1 juga menjadi formula terbaik dengan kandungan gizi berupa kadar air 46,90%, kadar abu 2,32%, protein 11,77%, lemak 7,60%, kalsium 5,52 mg/100 gr dan zink 16,63 mg/100 gr.  Kesimpulan dari penelitian ini adalah pada ketiga perlakuan, formula terpilih adalah F1 dengan penambahan ikan bilih sebanyak 5%.
Use of carbon electrodes to reduce mobile ion concentration and improve reliability of metal halide perovskite photovoltaics
Authors: Penukula Saivineeth , Tippin Favian , Li Muzhi , Khawaja Kausar Ali , Yan Feng , Rolston Nicholas
Published: June 2024

Ion migration is one of the prime reasons for the rapid degradation of metal halide perovskite solar cells (PSCs), and we report on a method for quantifying mobile ion concentration (No) using a transient dark current measurement. We perform both ex-situ and in-situ measurements on PSCs and study the evolution of No in films and devices under a range of temperatures. We also study the effect of device architecture, top electrode chemistry, and metal halide perovskite composition and dimensionality on No. Two-dimensional perovskites are shown to reduce the ion concentration along with inert C electrodes that do not react with halides by ~99% while also improving mechanical reliability by ~250%. We believe this work can provide design guidelines for the development of stable PSCs through the lens of minimizing mobile ions and their evolution over time under operational conditions.
“Our curriculum ourselves”: A participative approach to curriculum development on ethics and professionalism for community health workers
Authors: Gopichandran Vijayaprasad , Subramaniam Sudharshini , Palanisamy Balasubramanian , Chidambaram Priyadarshini
Published: June 2024

Based on a felt need for training of community health workers on ethics and professionalism, we embarked on an attempt to develop a curriculum for the short course. We conducted interviews among community health workers and community members in Tamil Nadu and compiled a set of case vignettes to use in this course. Then we gathered an expert panel to come together for a two-day consultative workshop to develop and refine this curriculum. This expert panel had community health workers, civil society representatives, representatives from non-governmental organisations working in the health sector and academics and researchers from public health. We deliberated on various aspects of the course. In this report, we describe the participative process of curriculum development for training of community health workers on ethics and professionalism.
SENSE RELATION IN VOCABULARY ACQUISITION
Authors: Jashari (Cicko) Alda
Published: June 2024

Foreign language teachers must select vocabulary carefully to ensure that high quality items are included and provide varied opportunities for practice. Teachers should pay the most prudent attention in organization of lexis for the classroom as to offer as wide a range of practice ideas in order to facilitateeffective learning. Acquiring a large, coloured and nuanced vocabulary knowledge does not imply simply studying a list of words alongside with dictionary definitions. Language diversity implies great possibilities of lexical choice as means of enhancing the effectiveness and accuracy of speech. Modern foreign languages teaching methods should aim at building a broad, deep, rich and flexible vocabulary corpus of words. Grouping of words is based upon similarities and contrasts. Every language has in its lexicon a variety of words, kindred in meaning, but distinct in morphemic composition and usage, ensuring the expression of the most delicate and somehow hidden shades of human perception, thought, feeling and imagination. The use of synonyms and antonyms is a quick and effective way of explaining unknown words and teachers can resort to them as means of describing words’ meanings.
PARENTAL INVOLVEMENT: WHY IS IMPORTANT AND HOW TO INVOLVE PARENTS IN SCHOOLS?
Authors: Stojanovska Vesna
Published: June 2024

This article is an in-depth qualitative literature review on the importance, benefits, and ways of parental involvement in the education of their children. It highlights the fact that parental involvement in their child's learning process offers many opportunities for success – improvements in the child's academic achievement, and social and emotional adjustment. The collaboration between the parent and the teacher is an important prerequisite for encouraging the full development of the child. It is therefore, parental involvement should be seen as an important tool for the advancement of the quality of education that should be part of regular school practice.

The paper also analyzes the possibilities for parent participation in the various aspects of school life. Parental involvement can have different types, from simple informational conversation, and consulting parents, to active and passive participation of parents in curricular and extracurricular activities.
Synergistic Responses Conferred by Concurrent Optical and Magnetic Stimulation are Attenuated by Simultaneous Exposure to Streptomycin: An Aminoglycoside Antibiotic Dilemma
Authors: Iversen Jan Nikolas , Fröhlich Jürg , Tai Yee Kit , Franco-Obregón Alfredo
Published: June 2024

Concurrent Optical and Magnetic Stimulation (COMS) combines extremely low frequency electromagnetic and light stimulation modalities for enhanced wound healing. In this report, we investigated the potential mechanistic synergism between magnetic and light components by comparing their individual and combined cellular responses. Although each individual stimulation mode was capable of stimulating cell proliferation, magnetic fields exposure alone produced greater proliferation enhancement than light alone, yet their combined effects of were supra-additive of the individual responses. Reactive oxygen species were incrementally reduced by exposure to light, magnetics fields and their combination, where statistical significance was ultimately achieved. On the other hand, ATP production was significantly enhanced in response to magnetic exposure alone or in combination with light. These results suggest that mitochondrial respiratory efficiency was preferentially improved by the combination of the two stimuli. Protein expression related to cell proliferation was preferentially enhanced by the combinatory COMS modality as were the protein levels of the TRPC1 cation channel previously implicated as part of a calcium-mitochondrial signaling axis invoked by electromagnetic exposure and involved in proliferation. These results corroborate that light facilitates functional synergism with magnetic fields that ultimately impinge on mitochondria-dependent developmental responses. The aminoglycoside antibiotics (AGAs) have been previously shown to antagonize TRPC1-mediated magnetotransduction. Streptomycin applied during the exposure to any of the stimulation modes reduced proliferation enhancement, whereas streptomycin added after the exposure did not. Notably, the COMS modality and magnetic field exposure were capable of partially overcoming streptomycin antagonism of proliferation, whereas light alone was not. Transductional antagonism of combinatorial photon-electromagnetic effects by streptomycin thus aligns with previous studies showing that the AGAs block TRPC1-mediated magnetotransduction when applied during exposure. The prophylactic usage of the AGAs (neomycin) should be avoided during COMS therapy to maintain clinical efficacy and would be a common concern with most other electromagnetic regenerative paradigms.
Analysis of Cooling Technologies in the Data Center Sector on the Basis of Patent Applications
Authors: Ott Benjamin , Wenzel Paula Marlene , Radgen Peter
Published: June 2024

The cooling of server components has been continuously developed over the past few years in order to meet the increasing cooling requirements of server component manufacturers such as for the processor chips. The growth in performance and power density increases the cooling demand. These requirements directly influence the energy consumption and performance of the hardware. To gain a better understanding of the historical evolution and possible future technology development paths in the field of data center cooling, a patent analysis method was used. The focus is on previous and current development priorities and possible research gaps within the server and computer room levels. The European patent database was selected as data source. To determine relevant patents, the search terms for various cooling technologies were developed iteratively. After the patent extraction for the period 2000 - 2023 (earliest priority year), the search results were classified and analysed. Most of the patents deal with air or liquid cooling. In the area of liquid cooling, the focus was on direct liquid cooling, followed by total liquid cooling. Since 2015 a technological shift from air to liquid cooling can be identified on the level of patent activities. In this context, the patent groups with focus on “constructional details for different types of electric apparatus” and “electrical digital data processing” have the largest share of patents. In addition, the technology focus of the TOP 10 patent applicants was in the field of liquid cooling. In conclusion from the patent analysis, it can be derived that liquid cooling will continue to gain in importance in the future and could also be combined with other approaches in the form of hybrid cooling. However air cooling may still be relevant, even if the main cooling load is handled by liquid-based approaches. At the same time, the optimisation potential for air cooling seems to have been largely exploited in comparison to liquid cooling, as can be seen from the falling number of the patent applications.
AI Face-Capture for First-time Passport Application
Authors: SARKER MD ABDUL BASET , Imtiaz Masudul H.
Published: June 2024

This paper presents the development and implementation of a Pan-Tilt-Zoom (PTZ) camera interfaced with a Jetson processor hosting Artificial Intelligence (AI) algorithms, designed to address the challenges of traditional biometric capture for first-time passport photos of young children. The system enhances the accuracy, efficiency, and adaptability of facial biometric capture by recognizing and accommodating the dynamic and diverse behaviors of children. Utilizing AI, the system detects faces and analyzes facial features using 68 landmark points, ensuring high-quality images that meet ISO standards. These technical specifications, implementation process, and performance evaluations of the developed system are provided in this paper, demonstrating the potential of the proposed AI Face-Capture to advance biometric identification and verification for young children.
Mechanisms of Low-Temperature Dislocation Motion in High-Entropy Al0.5CoCrCuFeNi Alloy
Authors: Semerenko Yuri , Natsik Vasilij , Tabachnikova Elena , Huang Yi , Langdon Terence G.
Published: June 2024

An analysis of the processes of plastic deformation and acoustic relaxation in a high-entropy alloy Al0.5CoCrCuFeNi was carried out. The following have been established: dominant dislocation defects; types of barriers that prevent the movement of dislocations; mechanisms of thermally activated movement of various elements of dislocation lines through barriers at room and low temperatures. Based on modern dislocation theory, quantitative estimates have been obtained for the most important characteristics of dislocations and their interaction with barriers.
Hypertriglyceridemia- from Innocent Bystander to Independent Cardiovascular Risk Factor in Younger Prehypertensives
Authors: Josipovic Josipa , Jelakovic Ana , Valent Moric Bernardica , Prelevic Vladimir , Mirosevic Gorana , Matijaca Hana , Ivanko Iva , Bulj Nikola , Gabric Ivo Darko , Jelakovic Bojan
Published: June 2024

Background: Population studies have shown that prehypertension is associated with adverse cardiometabolic risk profile even among apparently healthy populations. Although associations between serum triglyceride (TG) concentrations and the risk of atherosclerotic cardiovascular disease have been reported, there are lack of data on the association of hypertriglyceridemia with cardiovascular risk (CVR) in a low risk prehypertensive population. Aim: Our aim was to analyze the cardiorenometabolic characteristics of prehypertensives (PHT) compared to normotensives (NT) and untreated hypertensives (HT) and its associations with CVR. Materials and methods: In our cross-sectional study we included 323 apparently healthy untreated subjects 18-45 years who underwent basic anthropometric and standardized blood pressure measurement, fasting blood sampling, spot urine collection and transthoracic echocardiogram. Results: Higher BMI, waist circumference, HOMA-IR, LDL-cholesterol, TG, uric acid and LVMI contribute to higher CVR in PHT compared to true NT (p
Identification and Molecular Characterization of the Human GcMAF Receptor
Authors: Ruggiero Marco
Published: June 2024

This study proposes the first extracellular domain (residues 1-34) of the CCR1 protein as the Gc protein-derived Macrophage Activating Factor (GcMAF) receptor. The CCR1 gene, expressed in monocytes and 168 other cell types or tissues, encodes this transmembrane protein. Electrostatic and hydrophobic interactions, along with hydrogen bonds mediate the molecular interactions between the TPT420-GalNAcELAK (or TPK420ELAK) sequences of GcMAF (or Gc2 protein variant) and the TTEDYDTTT sequence of its receptor.
Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion
Authors: Megawati Dewi , Stroup Jeannine N. , Park Chorong , Clarkson Taylor , Tazi Loubna , Brennan Greg , Rothenburg Stefan
Published: June 2024

Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood. In this study, we analyzed the ability of YMTV and TPV orthologs of vaccinia virus K3 (called 012 in YMTV and TPV), which share 75% amino acid identity with one another, to inhibit PKR from 15 different primate species. We first used a luciferase-based reporter, and found that YMTV and TPV K3 orthologs inhibited PKR in a species-specific manner and showed distinct PKR inhibition profiles. TPV 012 inhibited PKR from 11 primates, including human, substantially better than YMTV 012. In contrast, both K3 orthologs inhibited the other four primate PKRs comparably well. Using YMTV 012 and TPV 012 hybrids, we mapped the region responsible for the differential PKR inhibition to the C- terminus of the K3 orthologs. Next, we generated chimeric vaccinia virus strains to investigate whether TPV K3 and YMTV K3 orthologs could rescue replication of a vaccinia virus strain that lacks PKR inhibitors K3L and E3L. Virus replication in primate-derived cells generally correlated with the patterns observed in the luciferase-based assay. Together, these observations demonstrate that yatapoxvirus K3 orthologs have distinct PKR inhibition profiles and inhibit PKR in a species-specific manner, which may contribute to the differential susceptibility of primate species to yatapoxvirus infections.
Can a Transparent Machine Learning Algorithm Predict Better than Its Black-Box Counterparts?: A Benchmarking Study using 110 Diverse Datasets
Authors: Peterson Ryan A. , McGrath Max , Cavanaugh Joseph E.
Published: June 2024

We developed a set of novel machine learning algorithms with the goal of producing transparent models (i.e. understandable-by-humans) while also flexibly accounting for nonlinearity and interactions. Our methods are based on ranked sparsity, and allow for flexibility and user-control in varying the shade of the opacity of black-box machine learning methods. In this work, we put our new ranked sparsity algorithms (as implemented in our new open-source R package, sparseR) to the test in a predictive model bakeoff on a diverse set of simulated and real-world data sets from the Penn Machine Learning Benchmarks database, including both regression and classification problems. We evaluate the extent to which our new human-centered algorithms can attain predictive accuracy that rivals popular black-box approaches such as neural networks, random forests, and SVMs, while also producing more interpretable models. Using out-of-bag error as a meta-outcome, we describe the properties of data sets in which human-centered approaches can perform as well as or better than black-box approaches. We find, interpretable approaches predicted optimally or within 5% of the optimal method in most real-world data sets. We provide a strong rationale for including human-centered transparent algorithms such as ours in predictive modeling applications.
Optimization of Magnetic Susceptibility Weighted Imaging for Female Pelvic Scans
Authors: Liu Wenjie , Yu Bin , Lv Furong , Liang Kaiwen , Xiao Zhibo
Published: June 2024

Background and Objectives: The existing recommendations for female pelvic magnetic susceptibility weighted imaging MRI (FP-SWI) have not been optimized to capture the disease characteristics of the female pelvis. Therefore, it is imperative to explore acquisition parameters before conducting larger-scale studies. To establish optimized flip angle (FA) for acquiring FP-SWI to improve the image quality of female pelvic lesion sites. Materials and Methods: To evaluate signal quality and lesion conspicuity, regions of interest (ROIs) were manually drawn within the lesion on SWI sequences. Signal intensity was measured within the ROIs. Additionally, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for SWI sequences acquired at three FA: 10°, 15°, and 20°. Finally, a qualitative assessment of anatomical detail visualization, geometric distortion extent, artifacts, and lesion clarity was performed using a four-point scale. The Wilcoxon rank sum test was employed to compare the qualitative evaluation parameters. The intra-class correlation coefficient (ICC) was calculated to determine the consistency of subjective ratings between two observers. Results: FA=10° showed significantly higher SNR than FA=15° and 20° in most anatomical regions (P<0.05), while the CNR was significantly higher than FA=15° and 20° (P<0.05). Compared with FA=15° and 20°, the image quality of FA=10° was significantly higher, with less distortion and ghosting, and better image contrast (P<0.05). Lesions with FA=10° exhibited higher clarity compared to FA=15° and 20° (P<0.05). Conclusions: The image quality of FP-SWI images at FA=10° exceeds that at FA=15° and 20°. We recommend that when conducting SWI examination of the female pelvic cavity, the FA value should be set at 10° to stabilize the SWI sequence and improve image quality.
Research on the Promotion Path of Intangible Cultural Heritage in Primary School Campus Based on the AGIL Model
Authors: Chen Yudan , Zheng Shuxian , Hua Ying , Sun Zhixue
Published: June 2024

With the introduction of policies to promote intangible cultural heritage into schools, intangible cultural heritage plays an increasingly important role in primary education. However, the implementation of the intangible cultural heritage policy in primary schools is mostly formalized, which leads to many problems in the introduction of intangible cultural heritage, such as mainly staying at the level of visual display and public opinion publicity, carrying out a small number of intangible cultural experience activities, and insufficient materialization and scenization of intangible cultural heritage, so that students cannot feel the inherent charm of intangible cultural heritage. In order to promote the development of intangible cultural heritage education, this paper uses the AGIL model of Parsons, literature analysis, case analysis and interview methods to study the promotion path of intangible cultural heritage in primary schools, and proposes solutions such as setting educational goals for school segments, setting up intangible cultural experience activities in schools, combining intangible cultural heritage with subject courses, and establishing a good maintenance mode. After the program is applied into practice, it is found that the use of storytelling by teachers to popularize the relevant knowledge of intangible cultural heritage is conducive to stimulating students' interest and prompting students to think. In addition, teaching and life practice should be combined, and students' five education should be emphasized at the same time to avoid teaching uniformity.
Unique Jurassic Fruits Shed a New Light on the Nature of Carpels
Authors: Fu Qiang , Sun Jie , Zheng Shaolin , Wang Xin
Published: June 2024

Carpels are a reproductive feature restricted to angiosperms, therefore they are a focus of many botanical studies. However, there are controversies over the nature of carpels. A reason underly-ing these controversies is mixing implications given by conflicting interpretations on fossil carpels in early fossil angiosperms from the Cretaceous. These controversies hinder a clear understanding of angiosperm evolution and systematics. A key to these questions is older fossil fruits bearing concerned information. Here we report a new fossil fruit, Xenofructus dabuensis gen. et sp. nov, from the Middle Jurassic of Liaoning, China. Unlike previously reported fruits of early angio-sperms that were interpreted as bearing seeds either on adaxial or abaxial margin by various au-thors, our fossil demonstrates clearly that the seeds in Xenofructus are neither borne on the adaxial nor abaxial margin of the fruit, instead the seeds of Xenofructus are borne on an axis positioned between two margins. This new feature implies that a placenta in carpels is an ovule/seed-bearing axis, a carpel is a composite organ comprising an enclosing leaf (fruit wall) and an axis (placenta). The adaxial or abaxial position of ovules/seeds frequently seen in fossil and extant angiosperms is a consequence derived through long time evolution (coalescence of placenta with either margin of fruits). Carpels can be taken as foliar structures enclosing their associated ovulate branches.
MANIFESTATIONS OF METABOLIC SYNDROME IN ORAL CAVITY IN MENTALLY ILL PATIENTS
Authors:   Kazan State Medical Academy, ILYINA ROZA J. , MUCHAMEDZHANOVA LUBOV R. ,   Chuvash State University, AKHMEDOVA GUZEL M. ,   Kazan State Medical Academy, GURJANOVA TATJANA V. ,   Republic Clinical Psychiatric Hospital named akad. V.M. Bekhterev, Kazan
Published: June 2024

Abstract. Introduction. The article considers the study results of the metabolic syndrome effect on the state of periodontal tissues in persons with mental disorders depending on the duration of the disease and the use of antipsychotics. Material and methods. In the Republic Clinical Psychiatric Hospital named V.M. Bekhterev of the Ministry of Health of Tatarstan Republic (Kazan) 206 patients who were treated for schizophrenia were examined. Depending on duration of disease, all patients were divided into three groups: 1 group with less than 5 years - (88 people), 2 group - from 5 to 10 years (73 people) and 3 group - more than 10 years (45 people). According to the analysis of medical records of inpatients, comorbidities were studied, the study included patients with cardiovascular diseases and diabetes mellitus. Recent indicators of systolic blood pressure, diastolic blood pressure, body mass index, fasting blood glucose index, low-density lipids, high-density lipids were recorded, a dental history and complaints were collected, and oral examination according to generally accepted criteria. For statistical results, a package of statistical programs SPSS 13.0. Results and discussion. It was revealed that diseases incidence of cardiovascular system, diabetes mellitus, systolic and diastolic blood pressure, glucose in the blood and low-density lipids significantly increased and positively correlated, depending on length of the patient's illness. The level of high-density lipids, while, on the contrary, decreased. Body mass index was the highest in the group of patients with 5 to 10 years of age experience and then tended to decline. The study identified a high prevalence of severe periodontitis in persons with mental disorders with 5 to 10 years of disease experience. With a severe degree of periodontitis, bleeding of the gums increased, these pathological changes were noted when the patient had a history of cardiovascular pathology and directly correlated with the level of systolic blood pressure, blood glucose and low-density lipids. Conclusion. The close association of periodontal conditions and manifestations of metabolic syndrome in persons with mental disorders suggests the need for an integrated approach to the treatment of oral diseases and a wide interdisciplinary interaction.
ACHIEVEMENTS AND PROSPECTS OF DEVELOPMENT OF DEPARTMENTAL MEDICINE OF THE INTERNAL AFFAIRS IN THE REPUBLIC OF TATARSTAN
Authors:   Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, FATYKHOV RENAT G. , SULTANOVA DILYA R. ,   Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, KHALITOV RASHID IL. ,   Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, FROLOV VIKTOR V. ,   Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, AMIROV NAIL B. ,   Kazan State Medical University
Published: June 2024

Abstract. Introduction. The article reflects the results of the activities of the medical unit, as an institution in which the symbiosis of science and practice contributes to the fulfillment of tasks to preserve the health of employees of the internal affairs bodies. Attention is paid to the strategic goals of the institution and directions for improving the quality and accessibility of medical care. Aim. The purpose of the study is to present the achievements of the medical service of the Ministry of internal affairs in the Republic of Tatarstan and identify the primary tasks and our plans for the future, including the introduction of modern approaches to the organization of medical support for employees of internal affairs bodies. Material and methods. An analysis of the activities of the medical unit as a medical and preventive institution of a high level of medical care and the quality of medical care was carried out for the period from 2017 to 2022. Results and discussion. The implementation of various tasks in strengthening and maintaining the health of employees of the internal affairs bodies is carried out with the constant improvement of diagnostic and treatment methods, timely updating of equipment, close interaction with the departments of higher medical educational institutions, whose leading employees and teachers use the latest achievements of research activities in their work. Conclusion. The medical and sanitary unit of the Ministry of internal affairs for the Republic of Tatarstan continues to fulfill the tasks assigned to it, as a result of effective leadership, continuous improvement and continuous work to improve the availability and quality of medical care.
MICROBIOTA OF THE ROOT CANAL SYSTEM IN PATIENTS WITH DESTRUCTIVE FORMS OF CHRONIC APICAL PERIODONTITIS BEFORE AND AFTER STANDARD ENDODONTIC TREATMENT AND MODERN POSSIBILITIES OF INFLUENCING IT
Authors:   Crimean Federal University, DEMYANENKO SVETLANA A. , MOROZOVA MARINA N. ,   Crimean Federal University, PAVLOVA NATALIA V. ,   Crimean Federal University, SHABLIY DMITRY N. ,   Crimean Federal University, KAZININA ELENA N. ,   Crimean Federal University, TOFAN YULIA V. ,   Crimean Federal University, KIRICHENKO VYACHESLAV N. ,   Crimean Federal University
Published: June 2024

Abstract. Introduction. Despite the modern achievements of endodontics, it is possible to obtain a positive effect in the treatment of destructive forms of chronic apical periodontitis in 80-85% of cases. In other patients, progressive pathology becomes the main cause of tooth loss with subsequent deformation of the dentition, changes in the temporomandibular joint, the development of purulent- inflammatory processes of the maxillofacial region or complicated course of somatic diseases. Aim. The aim of the study was to study the dynamics of microbiological parameters in patients with chronic apical periodontitis before and after standard endodontic treatment, as well as the possibility of exposure to blood autoplasm and hydroxyapatite gel.Material and methods. The study was conducted in 32 patients with destructive forms of chronic apical periodontitis. 82 scraping smears obtained from the apical third of the canal before its primary drug treatment were studied.Results anddiscussion.The study of the microflora of root canals in patients with destructive forms of chronic apical periodontitis after performing the main stages of the standard endodontic protocol showed that by the 10th day of treatment, small associations of microorganisms consisting of gram-positive and gram-negative coccoid, rod-shaped, convoluted forms, as well as fungal microflora, mainly Candida albicans, were found in the area of the root apex. An in vitro study of the antibacterial properties of blood autoplasm and hydroxyapatite gel showed that hydroxyapatite has a pronounced bactericidal effect on international test strains of bacteria Staphylococcus aureus ATCC 25923 and Candida albicans SSM 885, platelet-enriched blood autoplasm has a weak bactericidal effect, and the combined use of these drugs has no antibacterial effect.Conclusion. Taking into account the high osteoinductive properties of these substances, in order to achieve their positive effect on the course of inflammatory and regenerative processes, a scheme of their sequential inclusion in endodontic treatment can be used in order to optimize the existing standard protocol for destructive forms of chronic apical periodontitis, which is the subject of subsequent study.
Pengaruh Investment Opportunity Set, Liquidity, dan Corporate Social Responsibility terhadap Cash Holding
Authors: Mikyal Farialmira  , Nuramalia Hasanah  , Aji Ahmadi Sasmi
Published: June 2024

This research aims to test and analyze the effect of Investment Opportunity Set, Liquidity, and Corporate Social Responsibility on Cash Holding. This study uses purposive sampling to select samples, using secondary data sources derived from the company's annual report and sustainability report on non-cyclical sector companies listed on the Indonesia Stock Exchange (IDX) from 2020 to 2022. The final number of samples obtained was 52 companies with a total observation of 156 data. The data analysis technique used is panel data regression analysis through data processing performed on EViews 12 software. The results of testing the hypothesis of this study indicate that corporate social responsibility has no effect on cash holding, while investment opportunity set and liquidity has affect on cash holding.
Nineteen-Year-Old Woman with Symptomatic Intramuscular Thigh Hemangioma—Radiographic Changes and Management
Authors: Puleo James M. , Acosta Ernesto M. , Crowley Stephen G. , DiCaprio Matthew R.
Published: June 2024

Case:

We report a case of an intramuscular thigh hemangioma in a 19-year-old woman with a several year history of atraumatic thigh pain. Radiographs obtained by her primary care physician demonstrated periosteal bone reaction, prompting referral to Orthopaedic Oncology department. The patient had successful symptomatic management with propranolol.

Conclusion:

The case highlights the diagnosis and potential treatments. In a stepwise approach to care for symptomatic benign vascular lesions, propranolol has been a proven therapeutic option and may be a useful first-line therapy for symptomatic hemangiomas.
Potential Utilization of Cocoa Waste from Gunung Kidul Cocoa Fermentation Center: The Influence of NaOCl in Cellulose Extraction from Cocoa Pod Husk
Authors: Alfi Zaini Amrillah Nafira , Hanum Farrah Fadhillah , Rahayu Aster , BalqisViratu Hapsari Alliya , Nuraini Nuraini
Published: June 2024

The side of the production of the Gunung Kidul Cocoa Fermentation Center, DIY, in the form of cocoa pod husk, can cause a buildup of rubbish and become a nest for fungi that cause disease. Maximizing the use of cocoa shell waste is an effort so that people can increase the use value of waste into products that have higher economic value, one of which is extracting the cellulose. Cellulose fiber has several advantages such as good mechanical properties, low density, environmentally friendly, abundant, cheap, non-toxic, easily degraded, and included in renewable natural resources. Cellulose is obtained through an extraction process with two stages, namely alkaline delignification and bleaching. Therefore, this research aims to utilize the potential of cocoa pod husk in cellulose extraction for optimum conditions for the bleaching process with NaOCl 5%, 8%, 10% and 12% through analysis of yield, water content, ash content and FTIR characterization. Based on research that has been carried out, optimum results for cellulose are obtained through bleaching NaOCl 8% which has the best level of lightness and a yield of 52%. Chesson datta characterization also shows that cellulose NaOCl 8% NaOCl has the lowest water content and ash content, namely 1.4% and 0.8% respectively. FTIR analysis shows that the optimum results have the -OH stretching functional group as a representation of cellulose at wave numbers 3206 cm-1, 3442 cm-1 and 3600 cm-1. The presence of a peak in the wave number indicates that the bleaching process has succeeded in isolating the cellulose in the cocoa pod husk.
The Utilization of Citronella (Cymbopogon nardus) Oil and Butterfly Pea Flower Extract in The Production of Mosquito Repellent Lotion
Authors: Triastuti Desy , Sobari Enceng
Published: June 2024

Citronella is an essential oil-producing plant that has the potential to be used as a mosquito repellent agent since it contains citronellal, citronellol and geraniol components. The aim of this research was to determine the physicochemical and organoleptic characteristics of mosquito repellent lotion prepared from citronella oil and butterfly pea flower extract. A completely randomized design of 4 treatments of citronella oil (0%, 2%, 4%, and 6%) and 3 replications was used in this study. The parameters observed include physicochemical characteristics (spreadability, protection, emulsion stability, and pH) and organoleptic (level of preference for color, texture, aroma, and sticky impression) of repellent. The data was analyzed using the One Way ANOVA followed by DNMRT at 5% significance level. The results showed that the use of citronella oil gave a significant difference in physicochemical characteristics (spreadability, protection ability, emulsion stability, the pH value) and organoleptic (level of preference for color and texture) of mosquito repellent lotion. However, it had no significant result to the preference of the aroma and the impression of stickiness. The pH values of the lotion were above the standard value required by SNI. The best protection ability of the lotion was treatment 6% yet it had a texture issue, so it needs to be improved.
Analisis Faktor-Faktor yang Memengaruhi Persepsi Masyarakat Kota Jakarta Selatan Terhadap Wakaf Uang
Authors: Hasan Nurul Ichsan , Puspita Sari Imelda
Published: June 2024

Cash waqf is one of the Islamic economic instruments in the form of social funds and is voluntary. In addition, cash waqf can also be used as an alternative instrument to reduce poverty and inequality in Indonesia. However, the fact is evidenced by the data, that the realization of the collection of cash waqf is not in accordance with the calculation of its potential. One of the causes is the perception of each individual or society towards the cash waqf itself. This research was conducted to determine the public perception of cash waqf. The factors used in this study are factors of religiosity, income, education, understanding, and access to information media. The method used in this research is multiple regression analysis method. This research was conducted in the city of South Jakarta involving 100 respondents. The results of this study indicate that about 62% of the public know about cash waqf, but only about 38% have ever had cash waqf, so this is what makes the potential for the realization of its collection to be a gap. Based on the results of data analysis, it is known that the perception of the people of South Jakarta City is significantly influenced by the internal factors of the community itself, namely the level of individual understanding of cash waqf. While the internal factors that have no significant effect on people's perceptions of cash waqf are religiosity, income and education, the external factors are access to information media.
Investment Risk Management in Sharia Banking : A Literature Study
Authors: Suhartini Nani , Arsy Tamika Radhya , Nor Azhar
Published: June 2024

An incident that carries the possibility of causing financial loss is called a risk. In banking, investment risk is the risk that necessitates the bank to take a portion of the losses from a customer's business that has been financed through profit-sharing arrangements that include the profit and loss sharing and net revenue sharing methods. The purpose of this study is to examine the factors that influence investment risk and how they affect Islamic banking, as well as how investment risk management is applied there. The present investigation employs a literature study methodology to address the research objectives. Content analysis is the analytical technique employed in this study. According to the study's findings, there are variations in the investment risks associated with Islamic banking, namely between mudharabah and musyarakah investment risks.
Business to Business (B2B) Model from an Islamic Economic Perspective
Authors: Soumena Fadly Yashari , Afifa Nur , Amanah Indri Nur , Julian Antoni
Published: June 2024

The development of online technology has given birth to many types of businesses, including online businesses. These various forms of online business include business-to-business (B2B). B2B is a typical business that connects business actors in a business transaction. Business-to-business (B2B) in a sharia economic perspective refers to transactions between companies that are in accordance with sharia economic principles. It involves the exchange of goods and services between business entities that comply with the laws of Islamic economics. The main principles of sharia economics that must be adhered to in the B2B context include the prohibition of usury (interest), the prohibition of maysir (gambling), and the prohibition of gharar (uncertainty or excessive speculation). B2B transactions in the Islamic economy must also comply with the principles of justice, fairness, and compliance with Islamic laws. So the journal we are writing about will discuss and study business-to-business (B2B), especially from a Sharia economic perspective. The method used in this re-search is a study of primary sources taken from academic journals and relevant published literature. Due to these limitations, analytical studies regarding B2B practices outline Sharia principles and protocols with Islamic business ethics in online commerce.
Educational attainment polygenic risk score and symptom severity change after Internet-delivered cognitive behaviour therapy for depression and anxiety
Authors: Bäckman Julia , Wallert John , Halvorsen Matthew , Crowley James , Mataix-Cols David , Rück Christian
Published: June 2024

Depressive and anxiety disorders are among the leading causes of disability worldwide. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom change from clinical variables alone is challenging. Genetic data could potentially add predictive power and help us understand who will benefit most from ICBT. We conducted a study including 2668 adults (62% women, mean age 35.6 years) from the Swedish MULTI-PSYCH cohort to investigate the association between polygenic risk scores (PRS) from eight psychiatric and cognitive phenotypes and symptom change after ICBT. All participants had been diagnosed with depression, panic disorder or social anxiety disorder and treated with ICBT. The primary clinical outcome was a harmonised score across three different diagnosis-specific symptom rating instruments and measured weekly throughout ICBT. PRS were computed for attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder and schizophrenia, cross-disorder psychopathology, educational attainment, and intelligence, using large discovery data sets. Linear mixed-effects models identified a significant association between the PRS for educational attainment (PRS-EDU) and symptom change (B = -0.73, p = .03), suggesting that a higher PRS-EDU was associated with lower symptom severity. This remained significant after additional covariate adjustment. No other PRS were significant. In the adjusted model, there was a significant PRS-EDU*time interaction, indicating that PRS-EDU also influenced the symptom change rate during treatment. When excluding outliers, the interaction effect was significant in both the crude and adjusted model. While these results await replication, they could have important implications for how the ICBT could be adapted to suit a wider portion of the population.
Gut Microbiome in Tendinopathy: Mendelian Randomization and Bioinformatics Therapeutic Targets Study
Authors: Abdou Ihab Elsayed Mohamed Ali , Thein-Win Min , Ming Hao
Published: June 2024

Objective: To explore the relationship between the gut microbiome (GM) and tendinopathy, examining possible shared pathogenic pathways and relevant genes of significant importance.
Design:This study employed a two-sample bidirectional and multivariable Mendelian Randomization (MR) approach, supplemented by bioinformatics analysis.
Patients: The MR analysis utilized summary statistics from the genome-wide association studies of gut microbial taxa (Dutch Microbiome Project, n=7738). Data on five different tendinopathy phenotypes were sourced from the FinnGen database, encompassing Achilles tendinitis (AT, n_cases=3113), bicipital tendinitis (BT, n_cases=1317), tendinitis of the shoulder (ST, n_cases=1646), gluteal tendinitis (GT, n_cases=854), and patellar tendinitis (PT, n_cases=439). Genetic data for tendinopathy used in the bioinformatics analysis were derived from 23 patients.
Intervention (s): None.
Mains Outcome Measure: Incidences of Achilles tendinitis (AT), tendinitis of the shoulder (ST), bicipital tendinitis (BT), gluteal tendinitis (GT), and patellar tendinitis (PT).
Result(s): We identified 33 causal relationships between specific gut microbiota (GM) and various forms of tendinitis. Key findings include eight GMs causally related to AT and nine to BT. Five GMs showed significant associations with GT, and another nine with PT. Three specific GMs were significantly associated with ST. Bioinformatics analysis of tendinopathy samples revealed 682 differentially expressed genes (DEGs). We identified 711 genes associated with 28 gut microbiotas after excluding five due to pleiotropy, reverse causality, and unspecified reasons. The analysis identified 682 DEGs and 711 GMs-associated genes, with an overlap of 28 common gene sets (CGS). Enrichment analysis of the 13 CGS identified four major gene pathways. Using a Protein-Protein Interaction (PPI) network, we targeted the key gene FN1.
Conclusion (s): Our findings suggest a genetic correlation between 33 GMs and various tendinopathies, potentially mediated by the overexpression of the FN1 gene and the regulation of four gene pathways.
Comprehensive analysis of the metabolomics and transcriptomics uncovers the dysregulated network and potential biomarkers of Triple Negative Breast Cancer
Authors: Gong Sisi , Liao Zhijun , Wang Meie , Lian Fen , Tong Ruirui , Huang Rongfu , Fan Chun mei
Published: June 2024

Triple-negative breast cancer (TNBC) is recognized for its aggressive nature, lack of effective diagnosis and treatment, and generally poor prognosis. The objective of this study was to investigate the metabolic changes in TNBC using metabolomics approaches and to explore underlying mechanisms through integrated analysis with transcriptomics. In this study, serum untargeted metabolic profiles were firstly explored between 18 TNBC and 21 healthy controls (HC) by liquid chromatography-mass spectrometry (LC-MS), identifying a total of 22 significantly altered metabolites (DMs). Subsequently, the receiver operating characteristic analysis revealed that 7-methylguanine could serve as a potential biomarker for TNBC in both the discovery and validation sets. Additionally, transcriptomic datasets were retrieved from the GEO database to identify differentially expressed genes (DEGs) between TNBC and normal tissues. An integrative analysis of the DMs and DEGs was subsequently conducted, uncovering potential molecular mechanisms underlying TNBC. Notably, three pathways—tyrosine metabolism, phenylalanine metabolism, and glycolysis/gluconeogenesis—were enriched, explaining the energy metabolism disorders in TNBC. Within these pathways, two DMs (4-hydroxyphenylacetaldehyde and oxaloacetic acid) and six DEGs (MAOA, ADH1B, ADH1C, AOC3, TAT, and PCK1) were identified as critical components. In summary, this study highlights metabolic biomarkers that could potentially be utilized for the diagnosis and screening of TNBC. The comprehensive analysis of metabolomics and transcriptomics data provides a validated and in-depth understanding of TNBC metabolism.