bluuebunny/crossref_metadata_2025 huggingface dataset:
AI as a constituted system: accountability lessons from an LLM experiment
Authors: Nabben Kelsie
Published: November 2024

This study focuses on the practicalities of establishing and maintaining AI infrastructure, as well as the considerations for responsible governance by investigating the integration of a pre-trained large language model (LLM) with an organisation’s knowledge management system via a chat interface. The research adopts the concept of “AI as a constituted system” to emphasise the social, technical, and institutional factors that contribute to AI’s governance and accountability. Through an ethnographic approach, this article details the iterative processes of negotiation, decision-making, and reflection among organisational stakeholders as they develop, implement, and manage the AI system. The findings indicate that LLMs can be effectively governed and held accountable to stakeholder interests within specific contexts, specifically, when clear institutional boundaries facilitate innovation while navigating the risks related to data privacy and AI misbehaviour. Effective constitution and use can be attributed to distinct policy creation processes to guide AI’s operation, clear lines of responsibility, and localised feedback loops to ensure accountability for actions taken. This research provides a foundational perspective to better understand algorithmic accountability and governance within organisational contexts. It also envisions a future where AI is not universally scaled but consists of localised, customised LLMs tailored to stakeholder interests.
The Church as a Fragile State: A New Institutional Model for Understanding the Persistence of the Sexual Abuse Crisis
Authors: Anderson C. Colt
Published: November 2024

The institutional model of the church has fallen into disfavor as a means for ecclesiological investigation because Avery Dulles, SJ, regarded it with suspicion because of its association with the notion that the church is a perfect state and the ways that institutionalism encourages clericalism. At the same time, there has been an ongoing debate as to the value of models for addressing the concrete reality of the church and for engaging the social sciences. Engaging economics as a dialogue partner, the author considers how the institutional model can be understood in terms of a fragile state instead of a perfect society to explain the persistence of sexual abuse in the Catholic Church and to suggest a strategy for institutional reforms.
A prospective study of antenatal anxiety and depression in pregnant women with polycystic ovary syndrome
Authors: Floyd R. , Hughes N. , O’Sullivan L. , Hevey D. , Murphy N. , Hinds C. , Owens L.
Published: November 2024

Background:

Women with polycystic ovary syndrome (PCOS) experience higher rates of depression and anxiety. There is limited research relating to perinatal mental health in women with PCOS. Studies suggest PCOS is associated with a higher prevalence of perinatal mental health disorders. Perinatal guidelines currently do not recognise PCOS as a risk factor for perinatal mental health disorders. We aimed to prospectively assess the prevalence of mental health disorders in pregnant women with PCOS.

Methods:

Consenting pregnant women, with and without PCOS, were invited to participate. Standardised validated questionnaires were carried out including Generalised Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9) and Edinburgh Postnatal Depression Scale (EPDS).

Results:

Fifty-one with PCOS and 49 without PCOS responded. Pregnant women with PCOS had a higher mean (SD) anxiety score (GAD-7) than those without PCOS (8.2 [6.7] vs. 5.89 [4.7], p = 0.04). Pregnant women with PCOS had higher mean (SD) depression scores than those without PCOS on EPDS (9.1 [6.4] vs. 6.4 [4.5], p = 0.02) but not PHQ-9 score (median (IQR) 4 (3–9) vs. 4 (2–7.5), p = 0.25). Women with PCOS were more likely to experience moderate/severe anxiety (PCOS 34%, control 20%) and moderate/severe depression (PCOS 34%, control 20%) symptoms than women without PCOS. Twenty-nine percent of pregnant women with PCOS had an EPDS score >13 showing significantly higher rates of severe depression (PCOS 29%, control 12%, p = 0.03).

Conclusion:

Our findings suggest a higher prevalence of perinatal depression and anxiety in women with PCOS. Our findings may suggest increased need for screening for mental health disorders in women with PCOS.
Group collaboration reduces delay discounting of intertemporal choices and its duration
Authors: Geng Xiaowei , Zhao Yating , Xu Shiyuan , Sun Xinye , Zhou Xiaolin
Published: November 2024

Many real-world intertemporal decisions involve a group of two or more individuals making consensual decisions through group collaboration. Here, we ask how group collaboration affects intertemporal choices. In two experiments, participants completed intertemporal choices individually first (the precollaboration phase). Then, participants were placed into groups of two or three and completed a similar intertemporal task, with the group arriving at a consensual decision on each trial (the group collaboration phase). Finally, participants once again completed the intertemporal choices individually (the postcollaboration phase). Results showed that after group collaboration, the delay discounting significantly decreased compared to before collaboration both at group level and at individual level. The effect of group collaboration on individual intertemporal choices was no longer discernible by 1 week later. Therefore, the current research demonstrates the effectiveness of group collaboration and provides a way to nudge both groups and individuals to make farsighted choices.
Richtmyer–Meshkov instability when a shock is reflected for fluids with arbitrary equation of state
Authors: Napieralski Mario , Cobos Francisco , Velikovich Alexander L. , Huete César
Published: November 2024

First predicted by Richtmyer in 1960 and experimentally confirmed by Meshkov in 1969, the Richtmyer–Meshkov instability (RMI) is crucial in fields such as physics, astrophysics, inertial confinement fusion and high-energy-density physics. These disciplines often deal with strong shocks moving through condensed materials or high-pressure plasmas that exhibit non-ideal equations of state (EoS), thus requiring theoretical models with realistic fluid EoS for accurate RMI simulations. Approximate formulae for asymptotic growth rates, like those proposed by Richtmyer, are helpful but rely on heuristic prescriptions for compressible materials. These prescriptions can sometimes approximate the RMI growth rate well, but their accuracy remains uncertain without exact solutions, as the fully compressible RMI growth rate is influenced by both vorticity deposited during shock refraction and multiple sonic wave refractions. This study advances previous work by presenting an analytic, fully compressible theory of RMI for reflected shocks with arbitrary EoS. It compares theoretical predictions with heuristic prescriptions using ideal gas, van der Waals gas and three-term constitutive equations for simple metals, the latter being analysed with detailed and simplified ideal-gas-like EoS. We additionally offer an alternative explicit approximate formula for the asymptotic growth rate. The comprehensive model also incorporates the effects of constant-amplitude acoustic waves at the interface, associated with the D'yakov–Kontorovich instability in shocks.
Swirling instability of viscous liquid jets with axial shear effect in gas surroundings
Authors: Xu Yiqian , Mu Kai , Xin Yi , Qiao Ran , Zhao Chengxi , Si Ting
Published: November 2024

Linear instability analysis of a viscous swirling liquid jet surrounded by ambient gas is carried out by considering the significant influence of axial shear effect. The jet azimuthal flow is assumed as a Rankine vortex, and the non-uniform velocity distribution in the jet axial direction is approximated by parabolic and error functions. The enhancement of jet rotation is found to promote the predominant mode with larger azimuthal wavenumbers, and the mode transition is decided by the competition between centrifugal force and axial shear stress. Subsequently, the influence of the axial shear effect is examined through changing the degree of shear stress and the thickness of the gas velocity boundary layer. It is found that an increase of jet average velocity or surface velocity in the axial direction leads to the predominant mode transition to smaller azimuthal wavenumbers, due to the combined effects of shear stress and gas pressure perturbation. A larger velocity difference between ambient gas and liquid jet also promotes the predominant modes with smaller azimuthal wavenumbers, and the physical mechanism is attributed to gas pressure perturbation. Phase diagrams of different azimuthal modes are given and compared with the study of Kubitschek & Weidman (J. Fluid Mech., vol. 572, 2007, pp. 261–286), where a static swirling column without axial shear stress was considered. The strengthened axial shear effect is found to delay the transition of predominant modes with the increase of angular velocity. Experimental studies considering the swirling jets with different axial velocities are further carried out, which validate the theoretical findings. Different instability mechanisms and their transition rules are also identified through energy budget analysis. This study is expected to give scientific guidance on understanding the instability mechanisms of the swirling jets that widely exist in natural phenomena and engineering applications.
A pore-scale resolved direct numerical simulation study for scaling analysis of the solutal convection in porous media
Authors: Jin Yan
Published: November 2024

Understanding the solutal convection is a crucial step towards accurate prediction of CO

$_2$

sequestration in deep saline aquifers. In this study, pore-scale resolved direct numerical simulations (DNS) are performed to analyse the scaling laws of the solutal convection in porous media. The porous media studied are composed of uniformly distributed square or circular elements. The Rayleigh numbers in the range

$426 \le Ra \le 80\,000$

, the Darcy numbers in the range

$1.7\times 10^{-8} \le Da \le 8.8\times 10^{-6}$

and the Schmidt numbers in the range

$250 \le Sc \le 10^4$

are considered in the DNS. The main time, length and velocity scales affecting the solutal convection are classified as the diffusive scales (

$t_I$

,

$l_I$

and

$u_I$

), the convective scales (

$t_{II}$

,

$l_{II}$

and

$u_{II}$

) and the shut-down scales (

$t_{III}$

,

$l_{III}$

and

$u_{III}$

). These scales determine the pore-scale Rayleigh number

$Ra_K$

and the Rayleigh number

$Ra$

. Based on the DNS results, the scaling laws for the transient dissolution flux are proposed in the different regimes of convection. It is found that the onset time of convection (

$t_{oc}$

) and the period of the flux-growth regime (

$\Delta t_{fg}$

) vary linearly with the convective time scale

$t_{II}$

. The merging of the original plumes and the re-initiation of the new plumes start in the same period, resulting in the merging re-initiation regime. Horizontal dispersion plays an important role in plume merging. The dissolution flux

$F$

and the time since the onset of convection

$t^{\ast }$

have an

$F / u_{II} \sim (t^{\ast }/ t_{II})^{-0.2}$

scaling in the later stage of the merging re-initiation regime. This scaling is caused by the merging of the low-wavenumber plumes. It becomes more pronounced with decreasing porosity and leads to the nonlinear relationship between the Sherwood number

$Sh$

and

$Ra$

when the domain is not high enough for the plumes to fully develop. According to the DNS results, a regime is expected that is independent of both

$Ra$

and

$Ra_K$

, while the dimensionless constant flux

$F_{cf}/u_{II}$

in this regime decreases with decreasing porosity. When the mean solute concentration reaches approximately 30 %, convection enters the shut-down regime. For large

$Ra$

, the dimensionless flux in the shut-down regime follows the scaling law

$F/u_{III}\sim (t/t_{III})^{-1.2}$

at large porosity (

$\phi =0.56$

) and

$F/u_{III}\sim (t/t_{III})^{-1.5}$

at small porosity (

$\phi =0.36$

or

$0.32$

). The study shows the significant pore-scale effect on the convection. The DNS cases in this study are mainly for simplified geometries and large

$Ra_K$

. This can lead to uncertainties of the obtained scaling coefficients. It is important to determine the scaling coefficients for real geological formations to predict a real CO

$_2$

sequestration process.
On the theory of body motion in confined Stokesian fluids
Authors: Procopio Giuseppe , Giona Massimiliano
Published: November 2024

We propose a theoretical method to decompose the solution of a Stokes flow past a body immersed in a confined fluid into two simpler problems, related separately to the two geometrical elements of these systems: (i) the body immersed in the unbounded fluid (represented by its Faxén operators); and (ii) the domain of the confinement (represented by its Stokesian multipoles). Specifically, by using a reflection method, and assuming linear and reciprocal boundary conditions (Procopio & Giona, Phys. Fluids, vol. 36, issue 3, 2024, 032016), we provide the expression for the velocity field, the forces, torques and higher-order moments acting on the body in terms of: (i) the volume moments of the body in the unbounded ambient flow; (ii) the multipoles in the domain of the confinement; (iii) the collection of all the volumetric moments on the body immersed in all the regular parts of the multipoles considered as ambient flows. A detailed convergence analysis of the reflection method is developed. In light of the practical applications, we estimate the truncation error committed by considering only the lower-order moments (thus, truncating the matrices) and the errors associated with the approximated expressions available in the literature for force and torques. We apply the theoretical results to the archetypal hydrodynamic system of a sphere with Navier-slip boundary conditions near a plane wall with no-slip boundary conditions, to determine forces and torques on a translating and rotating sphere as a function of the slip length and of the distance of the sphere from the plane. The hydromechanics of a spheroid is also addressed.
Preserving large-scale features in simulations of elastic turbulence
Authors: Yerasi Sumithra R. , Picardo Jason R. , Gupta Anupam , Vincenzi Dario
Published: November 2024

Simulations of elastic turbulence, the chaotic flow of highly elastic and inertialess polymer solutions, are plagued by numerical difficulties: the chaotically advected polymer conformation tensor develops extremely large gradients and can lose its positive-definiteness, which triggers numerical instabilities. While efforts to tackle these issues have produced a plethora of specialized techniques – tensor decompositions, artificial diffusion, and shock-capturing advection schemes – we still lack an unambiguous route to accurate and efficient simulations. In this work, we show that even when a simulation is numerically stable, maintaining positive-definiteness and displaying the expected chaotic fluctuations, it can still suffer from errors significant enough to distort the large-scale dynamics and flow structures. We focus on two-dimensional simulations of the Oldroyd-B and FENE-P equations, driven by a large-scale cellular body forcing. We first compare two positivity-preserving decompositions of the conformation tensor: symmetric square root (SSR) and Cholesky with a logarithmic transformation (Cholesky-log). While both simulations yield chaotic flows, only the latter preserves the pattern of the forcing, i.e. its fluctuating vortical cells remain ordered in a lattice. In contrast, the SSR simulation exhibits distorted vortical cells that shrink, expand and reorient constantly. To identify the accurate simulation, we appeal to a hitherto overlooked mathematical bound on the determinant of the conformation tensor, which unequivocally rejects the SSR simulation. Importantly, the accuracy of the Cholesky-log simulation is shown to arise from the logarithmic transformation. We also consider local artificial diffusion, a potential low-cost alternative to high-order advection schemes. Unfortunately, the artificially enhanced diffusive smearing of polymer stress in regions of intense stretching substantially modifies the global dynamics. We then show how the spurious large-scale motions, identified here, contaminate predictions of scalar mixing. Finally, we discuss the effects of spatial resolution, which controls the steepness of gradients in a non-diffusive simulation.
A universal scaling for the length scales of shock-induced separation
Authors: Mahalingesh Nikhil , Piponniau Sébastien , Dupont Pierre
Published: November 2024

Experiments of transitional shock wave–boundary layer interactions (SBLIs) over 6

$^\circ$

and 10

$^\circ$

compression ramps were performed at Mach number 1.65. The unit Reynolds number was varied by a factor of two between 5.6 million per metre and 11 million per metre. Schlieren flow visualization was performed, and mean flow measurements were made using Pitot probes. Free interaction theory was verified from pressure measurements for all operating conditions. A new non-dimensional parameter was developed for scaling the strength of the imposed shock, which was based on the pressure required to separate a boundary layer. The validity of this new scaling was supported by the reconciliation of large discrepancies in a diverse collection of experimental results on the length scales of transitional interactions. This non-dimensional scaling was also applied to turbulent interactions, where different models were used to determine the pressure required to separate a turbulent boundary layer. Finally, a direct comparison between transitional and turbulent SBLIs was made, which revealed new insights into the evolution of length scales based on the state of the boundary layer.
Flow of viscoelastic films over grooved surfaces with partial wetting
Authors: Pettas D. , Karapetsas G. , Syrakos A. , Dimakopoulos Y. , Tsamopoulos J.
Published: November 2024

We consider the steady flow of a viscoelastic film over an inclined plane featuring periodic trenches normal to the main flow direction. The trenches have a square cross-section and side length 5–8 times the capillary length. Owing to the orientation of the substrate, the film fails to coat the topographical feature entirely, forming a second gas–liquid interface inside the trench and two three-phase contact lines at the points where the free surface meets the wall of the trench. The volume of entrapped air depends on material and flow parameters and geometric conditions. We develop a computational model and carry out detailed numerical simulations based on the finite element method to investigate this flow. We solve the two-dimensional mass and momentum conservation equations using the exponential Phan-Thien & Tanner constitutive model to account for the rheology of the viscoelastic material. Due to the strong nonlinearity, multiple steady solutions possibly connected by turning points forming hysteresis loops, transcritical bifurcations and isolated solution branches are revealed by pseudo-arc-length continuation. We perform a thorough parametric analysis to investigate the combined effects of elasticity, inertia, capillarity and viscosity on the characteristics of each steady flow configuration. The results of our simulations indicate that fluid inertia and elasticity may or may not promote wetting, while shear thinning and hydrophilicity always promote the wetting of the substrate. Interestingly, there are conditions under which the transition to the inertial regime is not smooth, but a hysteresis loop arises, signifying an abrupt change in the film hydrodynamics. Additionally, we investigate the effect of the geometrical characteristics of the substrate, and our results indicate that there is a unique combination of the geometry and viscoelastic properties that either maximizes or minimizes the wetting lengths.
Alteration in microbes changed the contents of oviposition-deterrent pheromones on the Spodoptera litura egg surface
Authors: Hu Liming , Chen Yirui , Wu Qingjun , Zeng Qiumei , Zhang Taoli , Yu Guohui , He Muyang , Chen Dasong , Su Xiangning , Zhang Yuping , Zhang Zhenfei , Shen Jianmei
Published: November 2024

Microorganisms symbiotic with insects, whether permanently or temporarily, play a crucial role in the nutrition, development, reproduction, defence, and metamorphosis regulation. In some Lepidoptera, oviposition-deterrent pheromones (ODPs) on egg surface were used by pregnant females to modify the behaviour of conspecifics to avoid excessive competition for limited resources. In this study, we constructed four different Spodoptera litura groups, including, OH, OA, SH, and OA, which either feed on different hosts or grow in different environments. The 16S rDNA libraries of microbes from the egg surface of the four groups were constructed and sequenced. According to alpha and beta diversity indices, the microbes in environments and diets considerably influenced the richness, diversity, and community compositions of the microbiota on egg surfaces. The quantity of the main ODP components and the corresponding oviposition-deterrent activity among four groups were significantly differed among the four groups. The result of this study revealed that altering of microbes in environments or diets considerably changed the contents of ODP and oviposition-deterrent activity. As ODPs impart oviposition-deterrent activity towards closely related species, the findings of this study suggest that we should pay more attention to the role of symbiotic microorganisms in changing the ability of insects, especially sympatric species, to occupy the optimal niche when developing novel pest-control strategies.
Semiabelian varieties and transcendence on Weierstrass sigma functions
Authors: Pham Duc Hiep
Published: November 2024

We establish new results on complex and
$p$
-adic linear independence on a class of semiabelian varieties. As applications, we obtain transcendence results concerning complex and
$p$
-adic Weierstrass sigma functions associated with elliptic curves.
Editorial: ticks & tick-borne parasites and diseases
Authors: Tabor Ala E.
Published: November 2024

Ticks and tick-borne diseases affect humans, livestock, and wildlife in most regions of the globe. Although there are over 900 tick species globally, only approximately 10% of species are second to mosquitoes as major vectors of human and veterinary diseases. The 17 articles of this themed Special Issue highlight the current research trends associated with newly discovered tick species, concepts of tick evolution, new vaccinology approaches, factors affecting disease transmission, and factors affecting tick ecology and tick-borne disease epidemiology. Table 1 summarizes the articles in this Special Issue in alphabetical author order and Fig. 1 is a word cloud generated from the article titles. Of the 17 articles in this Special Issue, two are review articles (vaccinology) while the remaining 15 are original research articles. The topics range from tick control, to epidemiology, ecology, tick-borne disease control, tick-borne disease transmission, vaccine approaches, and the description of novel extant and extinct tick species. Fig. 2 is graphical representation of the articles within this Special Issue including tick hosts and the most representative tick species studied. The articles also include authors from most continents globally with first author contributions from Australia, Bangladesh, Brazil, Czech Republic, Germany, India, Mexico, Pakistan, South Africa, Spain, Turkey, United Arab Emirates, USA and Zambia. This issue is thus truly diverse which reflects the diversity of ticks, tick-borne diseases and they hosts they infest globally.
Examining the association between aggression and suicide attempts among army soldiers
Authors: Krauss Alison , Greene Ashley L. , Edwards Emily R. , Goodman Marianne
Published: November 2024

Background

Suicide is a major concern among active-duty military personnel. Aggression represents a salient risk factor for suicide among civilians, yet is relatively understudied among military populations. Although several theories posit a relation between aggression and suicide with putative underlying mechanisms of social isolation, access to firearms, and alcohol use, researchers have yet to test these potential mediators. This study uses rich, longitudinal data from the Army Study to Assess Risk and Resilience (STARRS) Pre/Post Deployment Study (PPDS) to examine whether aggression longitudinally predicts suicide attempts and to identify mediators of this association.

Methods

Army soldiers (N = 8483) completed assessments 1 month prior to deployment and 1, 2–3, and 9–12 months post-deployment. Participants reported on their physical and verbal aggression, suicide attempts, social network size, firearm ownership, and frequency of alcohol use.

Results

As expected, pre-deployment aggression was significantly associated with suicide attempts at 12-months post-deployment even after controlling for lifetime suicide attempts. Social network size and alcohol use frequency mediated this association, but firearm ownership did not.

Conclusions

Findings further implicate aggression as an important suicide risk factor among military personnel and suggest that social isolation and alcohol use may partially account for this association.
Enriching ultra-high risk for psychosis cohorts based on accumulated exposure to environmental risk factors for psychotic disorders
Authors: O'Donoghue Brian , Oliver Dominic , Geros Hellen , Sizer Holly , Thompson Andrew , McGorry Patrick , Nelson Barnaby
Published: November 2024

Background and hypothesis

Transition to psychosis rates within ultra-high risk (UHR) services have been declining. It may be possible to ‘enrich’ UHR cohorts based on the environmental characteristics seen more commonly in first-episode psychosis cohorts. This study aimed to determine whether transition rates varied according to the accumulated exposure to environmental risk factors at the individual (migrant status, asylum seeker/refugee status, indigenous population, cannabis/methamphetamine use), family (family history or parental separation), and neighborhood (population density, social deprivation, and fragmentation) level.

Methods

The study included UHR people aged 15–24 who attended the PACE clinic from 2012 to 2016. Cox proportional hazards models (frequentist and Bayesian) were used to assess the association between individual and accumulated factors and transition to psychosis. UHR status and transition was determined using the CAARMS. Benjamini–Hochberg was used to correct for multiple comparisons in frequentist analyses.

Results

Of the 461 young people included, 55.5% were female and median follow-up was 307 days (IQR: 188–557) and 17.6% (n = 81) transitioned to a psychotic disorder. The proportion who transitioned increased incrementally according to the number of individual-level risk factors present (HR = 1.51, 95% CIs 1.19–1.93, p < 0.001, pcorr = 0.01). The number of family- and neighborhood-level exposures did not increase transition risk (p > 0.05). Cannabis use was the only specific risk factor significantly associated with transition (HR = 1.89, 95% CIs 1.22–2.93, pcorr = 0.03, BF = 6.74).

Conclusions

There is a dose–response relationship between exposure to individual-level psychosis-related environmental risk factors and transition risk in UHR patients. If replicated, this could be incorporated into a novel approach to identifying the highest-risk individuals within clinical services.
Frailty Screening in Primary Care-Based Memory Clinics: Feasibility, Acceptability, and Preliminary Findings
Authors: Lee Linda , Patel Tejal , Hillier Loretta M. , McAiney Carrie , Skimson Kara , Conway Emma , Agla Caitlin , McKinnon Wilson Jane , Gregg Susie
Published: November 2024

We evaluated the feasibility and acceptability of frailty screening using handgrip strength with gait speed measures within four primary care-based memory clinics in Ontario. This mixed methods quality improvement initiative examined the reach, effectiveness, adoption, implementation, and maintenance of frailty screening from the perspective of patients (N = 216), care partners (N = 142), and healthcare providers (N = 9). Frailty screening was well-received by patients and care partners and perceived as quick and easy to administer and integrate into assessment processes by healthcare providers at all four memory clinics. The ease of integrating frailty screening into clinic processes was a key factor facilitating implementation; few challenges or suggestions for improvement were identified. All four clinics plan to continue frailty screening, three using the methods adopted in this study. Integrating frailty screening into memory assessments is feasible and acceptable and, given the interactional relationship between frailty and dementia, provides a significant opportunity to improve health outcomes for older adults.
Weak Institutions, Strong Movements: The Uneven Implementation of Abortion Policy in Latin America
Authors: Elverdin Ana Sofia
Published: November 2024

Across Latin American countries, there is remarkable heterogeneity in abortion legislation, ranging from full prohibition to legal elective abortion.1 However, abortion policy does not seem to clearly map onto implementation on the ground. On the one hand, even in countries with very restrictive abortion laws, (clandestine) abortion rates are comparatively high, and legislation that criminalizes abortion is rarely enforced (Blofield 2006; Htun 2003). On the other hand, in countries that allow abortion under all or some circumstances, access to abortion is not guaranteed. In Argentina, for instance, different reports have stressed the difficulty in accessing abortion procedures both before and after legalization was enacted in early 2021.2
Efficacy of medical compression stockings class I on the reduction of symptoms in patients with uncomplicated varicose veins
Authors: Stücker Markus , Braß Dennis , Möckel Luis , Hartmann Karsten , Rabe Eberhard
Published: November 2024

Summary: Background: Aim of this study was to analyze the effect of medical compression stockings (MCS) class I (according to the German classification “RAL-GZ 387”; 18–21 mmHg) on symptoms in patients with uncomplicated varicose veins (C2s–C4a). Patients and methods: We conducted a randomized (1:1), controlled, clinical trial enrolling patients with uncomplicated varicose veins (CEAP: C2s–C4a). The study consisted of a one-week baseline period and a four-week follow-up period with MCS treatment (compression class I, 18–21 mmHg) in the intervention group and non-treatment in the control group. The frequency and severity of symptoms on the leg including heaviness, pain, swelling, throbbing and itching were measured every evening using an app-based measuring tool. The primary endpoint was the reduction of symptoms during compression therapy, measured by a symptom sum score over a period of 5 weeks ranging from 0 (no symptoms during the day) to 25 (symptoms all day). Results: Patients treated with MCS (n = 25) showed a significant improvement in the overall symptom sum score from 8.90 ± 4.26 at baseline to 6.37 ± 3.55 at follow-up (p = 0.004) whereas for patients in the control group without MCS (n = 25) the overall score remained unchanged (baseline: 7.46 ± 3.71; follow-up: 7.67 ± 4.74; p = 0.293). The intervention group reported significant improvements in symptom frequency scores for pain, leg swelling and feeling of leg heaviness (p ≤ 0.002). In the control group the score for pain significantly increased during the follow-up period. Leg itching was numerically more frequent in patients with MCS. Conclusion: This study indicates that medical compression stockings class I (according to the German classification “RAL-GZ 387”; 18–21 mmHg) significantly improve the frequency and severity of symptoms in patients with uncomplicated varicose veins (CEAP: C2s–C4a).
Magnetospheric Control of Ionospheric TEC Perturbations via Whistler‐Mode and ULF Waves
Authors: Shen Yangyang , Verkhoglyadova Olga P. , Artemyev Anton , Hartinger Michael D. , Angelopoulos Vassilis , Shi Xueling , Zou Ying
Published: November 2024

The weakly ionized plasma in the Earth's ionosphere is controlled by a complex interplay between solar and magnetospheric inputs from above, atmospheric processes from below, and plasma electrodynamics from within. This interaction results in ionosphere structuring and variability that pose major challenges for accurate ionosphere prediction for global navigation satellite system (GNSS) related applications and space weather research. The ionospheric structuring and variability are often probed using the total electron content (TEC) and its relative perturbations (dTEC). Among dTEC variations observed at high latitudes, a unique modulation pattern has been linked to magnetospheric ultra‐low‐frequency (ULF) waves, yet its underlying mechanisms remain unclear. Here using magnetically conjugate observations from the THEMIS spacecraft and a ground‐based GPS receiver at Fairbanks, Alaska, we provide direct evidence that these dTEC modulations are driven by magnetospheric electron precipitation induced by ULF‐modulated whistler‐mode waves. We observed peak‐to‐peak dTEC amplitudes reaching 0.5 TECU (1 TECU is equal to electrons/) with modulations spanning scales of 5–100 km. The cross‐correlation between our modeled and observed dTEC reached 0.8 during the conjugacy period but decreased outside of it. The spectra of whistler‐mode waves and dTEC also matched closely at ULF frequencies during the conjugacy period but diverged outside of it. Our findings elucidate the high‐latitude dTEC generation from magnetospheric wave‐induced precipitation, addressing a significant gap in current physics‐based dTEC modeling. Theses results thus improve ionospheric dTEC prediction and enhance our understanding of magnetosphere‐ionosphere coupling via ULF waves.
Heat Fluxes in a Glacial Fjord: The Role of Buoyancy‐Driven Circulation and Offshore Forcing
Authors: Bonneau Jérémie , Laval Bernard E. , Mueller Derek , Hamilton Andrew K. , Antropova Yulia
Published: November 2024

The ocean supplies large quantities of thermal energy to tidewater glaciers, but the mechanisms behind the heat delivery are not fully understood. To examine heat flux dynamics in glacial fjords, we run an 8‐year realistic numerical simulation of Milne Fiord, validated with observations. We leverage the duration and spatial resolution of the simulation to calculate ice melt, offshore density variations, average fjord temperature, and heat fluxes at different locations along‐fjord. Correlations between these quantities reveal that heat fluxes near the grounding line (<5 km) are linked to buoyancy‐driven circulation while offshore forcing is linked to heat fluxes along the remainder of the fjord. Comparison to a simulation with constant offshore boundary conditions reveals that offshore forcing enhances the exchange between the coastal shelf and the fjord, increasing glacier melt rates by 18%. Including offshore forcing into numerical and box models of glacial fjords is essential for accurate melting predictions.
Peculiar Nighttime Ionospheric Enhancements Over the Asian Sector During the May 2024 Superstorm
Authors: Huang Fuqing , Lei Jiuhou , Zhang Shun‐Rong , Wang Yihan , Li Zhongli , Zhong Jiahao , Yan Rui , Aa Ercha , Zhima Zeren , Luan Xiaoli
Published: November 2024

This study reports a peculiar nighttime ionospheric enhancement in the total electron content (TEC) from the geostationary (GEO) satellites in response to the geomagnetic superstorm of May 2024. The enhancements occurred at low to mid‐latitudes during the storm's recovery phase on 11–12 May, with the TEC values almost twice as high as the quiet ones. Surprisingly, the nighttime ionospheric enhancements sub‐rotated westward with a speed of ∼130.5 m/s. The nighttime TEC enhancements lasted ∼5–7 hr for a given location and persisted over half a day over wide longitude ranges. Meanwhile, ionosonde data from two equatorial ionization anomaly (EIA) stations showed a higher peak height of the F2 layer, and a significant double‐crest EIA structure was observed by both GEO TECs and in situ electron densities from China Seismo‐Electromagnetic Satellite during this period of interest, indicating a possible contribution from disturbance electric fields producing nighttime eastward equatorial electric fields. Nevertheless, it remains a mystery whether the nighttime TEC enhancement and its movement were associated with the wind disturbance dynamo.
Investigating the Trip of a Transformer in Sweden During the 24 April 2023 Storm
Authors: Dimmock A. P. , Lanabere V. , Johlander A. , Rosenqvist L. , Yordanova E. , Buchert S. , Molenkamp S. , Setréus J.
Published: November 2024

Geomagnetically Induced Currents are unwanted currents that flow in large ground‐based conductive infrastructure and are a significant threat to bulk power grids. This susceptibility is increased at high latitudes due to the larger amplitude geomagnetic disturbances caused by the strong and dynamic auroral electrojet currents. In Sweden, there has been a record of disturbances connected to geomagnetically induced currents; the most documented was a blackout in Malmö, a city in southern Sweden, on 30 October 2003. However, on 24 April 2023, there was a transformer trip in the Bandsjö substation (near Sundsvall) around the time of enhanced space weather. In this paper, we investigate this event by studying the solar wind properties as well as geomagnetic disturbances. The study shows evidence that the transformer trip was caused by a strong geomagnetic disturbance in the morning sector. This was triggered by a high‐pressure sub‐structure within the interplanetary coronal mass ejection cloud, preceded by 2 hr of strong southward interplanetary magnetic field. Additionally, analysis of multiple ground magnetometers shows that the geomagnetic impact was highly spatially structured.
River Geomorphology and Fish Diversity Around the Manseriche Gorge, the Last Andean Crossing Is in Peril
Authors: Abad J. D. , Chicchon H. , Chuctaya J. , Mendoza A. , Valverde H. , Oshiro C. , Montoya M.
Published: November 2024

The transition from the Andes to the Amazon lowland hosts a high biodiversity and currently is facing several anthropogenic activities, including hydropower infrastructure projects. Little is known about the geomorphology of the Andean gorges, rivers and the interaction with the fish diversity upstream and downstream of gorges. The Marañón River is a major river that connects the Andes to the Amazon lowland and it carries 40% of the sediment load arriving to Brazil. The Santiago River is the last tributary into the Marañón River before the last gorge (Manseriche). Current plans for hydropower reservoirs include the construction of several dams along the Marañón River, being the largest with a 4,500 MW capacity at the Manseriche Gorge (MG). This study seeks to characterize the baseline processes of the hydrogeomorphology and fish diversity. Results show that the Santiago River is under transitional morphodynamic regime while the Marañón River is a fully developed anabranching river. This study reveals a clear difference in fish species richness and abundance between the upstream and downstream regions of the MG, with some species only found in specific regions. The MG acts as a natural boundary condition for the hydrogeomorphology and fish diversity. If the hydropower dam at MG was built, the reservoir in the upstream reach will produce the Santiago River to disappear and sedimentation to occur, consequently modifying sediment transport boundary conditions for the lower Marañón River. Downstream of the potential dam incision will occur, reducing lateral connectivity, particularly at sites where unique species were found.
An Attention‐Based Explainable Deep Learning Approach to Spatially Distributed Hydrologic Modeling of a Snow Dominated Mountainous Karst Watershed
Authors: Longyang Qianqiu , Choi Seohye , Tennant Hyrum , Hill Devon , Ashmead Nathaniel , Neilson Bethany T. , Newell Dennis L. , McNamara James P. , Xu Tianfang
Published: November 2024

In many regions globally, snowmelt‐recharged mountainous karst aquifers serve as crucial sources for municipal and agricultural water supplies. In these watersheds, complex interplay of meteorological, topographical, and hydrogeological factors leads to intricate recharge‐discharge pathways. This study introduces a spatially distributed deep learning precipitation‐runoff model that combines Convolutional Long Short‐Term Memory (ConvLSTM) with a spatial attention mechanism. The effectiveness of the deep learning model was evaluated using data from the Logan River watershed and subwatersheds, a characteristically karst‐dominated hydrological system in northern Utah. Compared to the ConvLSTM baseline, the inclusion of a spatial attention mechanism improved performance for simulating discharge at the watershed outlet. Analysis of attention weights in the trained model unveiled distinct areas contributing the most to discharge under snowmelt and recession conditions. Furthermore, fine‐tuning the model at subwatershed scales provided insights into cross‐subwatershed subsurface connectivity. These findings align with results obtained from detailed hydrogeochemical tracer studies. Results highlight the potential of the proposed deep learning approach to unravel the complexities of karst aquifer systems, offering valuable insights for water resource management under future climate conditions. Furthermore, results suggest that the proposed explainable, spatially distributed, deep learning approach to hydrologic modeling holds promise for non‐karstic watersheds.
Cryo-EM structure of PML RBCC dimer reveals CC-mediated octopus-like nuclear body assembly mechanism
Authors: Tan Yangxia , Li Jiawei , Zhang Shiyan , Zhang Yonglei , Zhuo Zhiyi , Ma Xiaodan , Yin Yue , Jiang Yanling , Cong Yao , Meng Guoyu
Published: November 2024

Promyelocytic leukemia protein (PML) nuclear bodies (NBs) are essential in regulating tumor suppression, antiviral response, inflammation, metabolism, aging, and other important life processes. The re-assembly of PML NBs might lead to an ~100% cure of acute promyelocytic leukemia. However, until now, the molecular mechanism underpinning PML NB biogenesis remains elusive due to the lack of structural information. In this study, we present the cryo-electron microscopy (cryo-EM) structure of the PML dimer at an overall resolution of 5.3 Å, encompassing the RING, B-box1/2 and part of the coiled-coil (RBCC) domains. The integrated approach, combining crosslinking and mass spectrometry (XL-MS) and functional analyses, enabled us to observe a unique folding event within the RBCC domains. The RING and B-box1/2 domains fold around the α3 helix, and the α6 helix serves as a pivotal interface for PML dimerization. More importantly, further characterizations of the cryo-EM structure in conjugation with AlphaFold2 prediction, XL-MS, and NB formation assays, help unveil an unprecedented octopus-like mechanism in NB assembly, wherein each CC helix of a PML dimer (PML dimer A) interacts with a CC helix from a neighboring PML dimer (PML dimer B) in an anti-parallel configuration, ultimately leading to the formation of a 2 µm membrane-less subcellular organelle.
Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates
Authors: Lanoizelet Maxence , Michel Léo , Lagadec Ronan , Mayeur Hélène , Guichard Lucile , Logeux Valentin , Séverac Dany , Martin Kyle , Klopp Christophe , Marcellini Sylvain , Castillo Héctor , Pollet Nicolas , Candal Eva , Debiais-Thibaud Mélanie , Boisvert Catherine , Billoud Bernard , Schubert Michael , Blader Patrick , Mazan Sylvie
Published: November 2024

The mode of evolution of left-right asymmetries in the vertebrate habenulae remains largely unknown. Using a transcriptomic approach, we show that in a cartilaginous fish, the catshark Scyliorhinus canicula, habenulae exhibit marked asymmetries, in both their medial and lateral components. Comparisons across vertebrates suggest that those identified in lateral habenulae reflect an ancestral gnathostome trait, partially conserved in lampreys, and independently lost in tetrapods and neopterygians. Asymmetry formation involves distinct mechanisms in the catshark lateral and medial habenulae. Medial habenulae are submitted to a marked, asymmetric temporal regulation of neurogenesis, undetectable in their lateral counterparts. Conversely, asymmetry formation in lateral habenulae results from asymmetric choices of neuronal identity in post-mitotic progenitors, a regulation dependent on the repression of Wnt signaling by Nodal on the left. Based on comparisons with the mouse and the zebrafish, we propose that habenular asymmetry formation involves a recurrent developmental logic across vertebrates, which relies on conserved, temporally regulated genetic programs sequentially shaping choices of neuronal identity on both sides and asymmetrically modified by Wnt activity.
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Authors: Schwalm Martin P. , Dopfer Johannes , Kumar Adarsh , Greco Francesco A. , Bauer Nicolas , Löhr Frank , Heering Jan , Cano-Franco Sara , Lechner Severin , Hanke Thomas , Jaser Ivana , Morasch Viktoria , Lenz Christopher , Fearon Daren , Marples Peter G. , Tomlinson Charles W. E. , Brunello Lorene , Saxena Krishna , Adams Nathan B. P. , von Delft Frank , Müller Susanne , Stolz Alexandra , Proschak Ewgenij , Kuster Bernhard , Knapp Stefan , Rogov Vladimir V.
Published: November 2024

Recent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) have received considerable attention from the drug development community. ATTECs are based on the recruitment of targets to LC3/GABARAP, a family of ubiquitin-like proteins that presumably bind to the autophagosome membrane and tether cargo-loaded autophagy receptors into the autophagosome. In this work, we rigorously tested the target engagement of the reported ATTECs to validate the existing LC3/GABARAP ligands. Surprisingly, we were unable to detect interaction with their designated target LC3 using a diversity of biophysical methods. Intrigued by the idea of developing ATTECs, we evaluated the ligandability of LC3/GABARAP by in silico docking and large-scale crystallographic fragment screening. Data based on approximately 1000 crystal structures revealed that most fragments bound to the HP2 but not to the HP1 pocket within the LIR docking site, suggesting a favorable ligandability of HP2. Through this study, we identified diverse validated LC3/GABARAP ligands and fragments as starting points for chemical probe and ATTEC development.