bluuebunny/crossref_metadata_2025 huggingface dataset:
A Urgente Necessidade da Inclusão de Psicologia Política nos Cursos de Direito no Brasil
Authors: Freitas Aline da Silva
Published: June 2022

A presente pesquisa sustenta a urgente necessidade da inclusão de Psicologia Política como componente curricular nos Cursos de Direito das Faculdades de Direito do Brasil, públicas ou privadas. Para tanto, contempla inicialmente noções gerais do conceito de Psicologia Política, apontando-a como um “campo interdisciplinar dinâmico”, que observa fenômenos políticos a partir do indivíduo e do coletivo, com temas de central interesse e relevância social. Após, apresenta a interface da Psicologia Política com o Direito, correlacionando objetos de estudo daquela com temas abordados em algumas disciplinas do Curso em questão, como Direito Constitucional e Psicologia Jurídica, entre outras. Para análise, toma-se por base o currículo dos melhores cursos segundo o Ranking Universitário da Folha. A partir disso, nota-se que Psicologia Política poderia atuar como matéria interdisciplinar, com elevado teor crítico-reflexivo, o que poderia auxiliar os estudantes de Direito para este tipo de visão, bem como gerar o aprofundamento de discussões sobre aplicabilidade de institutos, papel e efetividade das leis, bem como ainda, o mais importante, a potencialidade do direito diante de questões contemporâneas. Sustenta-se que o estudante também será melhor cidadão, consciente de si e da coletividade. Como tópico final, será recomendada a Psicologia Política como componente nos Cursos de Direito, sugerindo sua obrigatoriedade, eis que essencial à formação de todos os estudantes. Será levantada, neste item, a hipótese de estruturação da Psicologia Política do Direito, a mercê do que ocorreu nos cursos jurídicos com a Filosofia e a Psicologia Jurídica.
A Institucionalização das Discussões de Gênero nas Universidades: reflexões a partir das grades curriculares das graduações em Psicologia na cidade de São Paulo
Authors: Oliveira Beatriz Besen de , Rivera Mariana Fagundes de Almeida , Penha Diego Amaral , Moreira Lara Mundim , Costa Annielson de Souza , Taranta Daniel da Silva , Ansara Soraia
Published: June 2022

O presente artigo propõe uma reflexão acerca da importância da institucionalização da discussão de gênero no interior das universidades, a partir de um levantamento da ocorrência do termo “gênero” nos títulos e ementas das disciplinas que compõem as grades curriculares dos cursos de graduação em Psicologia da cidade de São Paulo. As universidades gozam de autonomia didático-científica, e pressupõe-se que sejam agentes de desenvolvimento social, estimulando a construçãode um pensamento e conhecimento crítico-reflexivos. Constatou-se que, mesmo com políticas e diretrizes que definem a inclusão da discussão de gênero nos currículos, a quase ausência de disciplinas com o termo “gênero” em seus títulos ou ementas indica que tal debate não está instituído nos cursos de Psicologia da cidade de São Paulo.
Eugênio Kusnet para os dias de hoje
Authors: Piacentini Ney Luiz
Published: June 2022

Este texto aborda, sucintamente, em primeiro lugar, a trajetória de Eugênio Kusnet, ator e professor de interpretação teatral, na cena brasileira nas décadas de 1950, 60, e 70. Paralelamente aos dados biográficos são feitos apontamentos de seu comportamento artístico e técnico em encenações de companhias teatrais como Os Comediantes, Companhia Maria Della Costa, Teatro de Arena e Teatro Oficina. Numa segunda parte é relatada sua viagem de volta à Rússia em 1968 com as consequências em sua pedagogia teatral. Por fim são analisados os reflexos da influência dos estudos sobre Eugênio Kusnet na prática cotidiana do ator Ney Piacentini na encenação de Ópera dos Vivos, da Companhia do Latão.
O “Performer Essencial” de Denise Stoklos fará sempre teatro (essencial)?
Authors: Silva Ipojucan Pereira da
Published: June 2022

Este artigo analisa as características do espetáculo solo no Teatro Essencial de Denise Stoklos, investiga e organiza os processos de atuação do performer essencial, por meio de pesquisa de gabinete, entrevistas e alguns espetáculos da atriz. Aponta-se que esse processo de atuação imbrica com o cotidiano e conduz o ator a se manter em estado de autopercepção, captando os elementos que farão parte da dramaturgia e fazendo com que articule o corpo e a voz, de modo a estimular no espectador percepções diferenciadas.
Técnica Klauss Vianna na construção de uma dramaturgia corporal
Authors: Silva Ceres Vittori , Toledo Érika , Menezes Jessiara , Maffi Kátia Maffi , Andrade Vitória Beatriz de Aquino
Published: June 2022

O artigo tem como objetivo apresentar e discutir o projeto de pesquisa “Técnica Klauss Vianna e dramaturgia corporal: estudo do sistema de movimento consciente em trabalho de atores”, desenvolvido na Universidade Estadual de Londrina com o objetivo de estudar os processos criativos do corpo do ator. O texto apresenta conceitos presentes na construção de uma arquitetura corporal capaz de ser atuante no processo de criação e descreve a Técnica como um sistema dinâmico de construção do movimento do ator.
Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice
Authors: Karshovska Ela , Mohibullah Rokia , Zhu Mengyu , Zahedi Farima , Thomas Dominique , Magkrioti Christiana , Geissler Claudia , Megens Remco T.A. , Bianchini Mariaelvy , Nazari-Jahantigh Maliheh , Ferreirós Nerea , Aidinis Vassilis , Schober Andreas
Published: June 2022

Background:

Maladapted endothelial cells (ECs) secrete ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2; autotaxin)—a lysophospholipase D that generates lysophosphatidic acids (LPAs). ENPP2 derived from the arterial wall promotes atherogenic monocyte adhesion induced by generating LPAs, such as arachidonoyl-LPA (LPA20:4), from oxidized lipoproteins. Here, we aimed to determine the role of endothelial ENPP2 in the production of LPAs and atherosclerosis.

Methods:

We quantified atherosclerosis in mice harboring loxP-flanked
Enpp2
alleles crossed with

Apoe
–/–

mice expressing tamoxifen-inducible Cre recombinase under the control of the EC-specific bone marrow X kinase promoter after 12 weeks of high-fat diet feeding.

Results:

A tamoxifen-induced EC-specific
Enpp2
knockout decreased atherosclerosis, accumulation of lesional macrophages, monocyte adhesion, and expression of endothelial CXCL (C-X-C motif chemokine ligand) 1 in male and female

Apoe
–/–

mice. In vitro, ENPP2 mediated the mildly oxidized LDL (low-density lipoprotein)-induced expression of CXCL1 in aortic ECs by generating LPA20:4, palmitoyl-LPA (LPA16:0), and oleoyl-LPA (LPA18:1). ENPP2 and its activity were detected on the endothelial surface by confocal imaging. The expression of endothelial
Enpp2
established a strong correlation between the plasma levels of LPA16:0, stearoyl-LPA (LPA18:0), and LPA18:1 and plaque size and a strong negative correlation between the LPA levels and ENPP2 activity in the plasma. Moreover, endothelial
Enpp2
knockout increased the weight of high-fat diet–fed male

Apoe
–/–

mice.

Conclusions:

We demonstrated that the expression of ENPP2 in ECs promotes atherosclerosis and endothelial inflammation in a sex-independent manner. This might be due to the generation of LPA20:4, LPA16:0, and LPA18:1 from mildly oxidized lipoproteins on the endothelial surface.
Impact of linear infrastructure on South Africa’s primate fauna: the need for mitigation
Authors: Linden Birthe , Cuozzo Frank P. , Sauther Michelle L. , Collinson Jonker Wendy
Published: June 2022

South Africa’s extensive linear infrastructure network (which includes roads and power lines) is severely impacting the country’s historically recognised five primate species: greater or thick-tailed bushbaby (Otolemur crassicaudatus), southern lesser bushbaby (Galago moholi), chacma baboon (Papio ursinus), vervet monkey (Chlorocebus pygerythrus) and samango monkey (Cercopithecus albogularis). We present South African mortality data from two different linear infrastructure types on a country wide scale, over a long-term sampling period. Using primate road mortality and power line electrocution data acquired from different data sources, we compare and discuss different mortality data collection methodologies, the resulting data quality and identify current limitations in understanding the direct impacts of linear infrastructure which have important implications for primate conservation planning. Between 1996-2021 a total of 483 primate mortalities were recorded on roads and power lines, the majority on the former. Vervet monkeys were most severely impacted by both linear infrastructure types whereas lesser bushbabies experienced the least number of mortalities. Both data sets showed numerous incidents where more than one individual was killed (roadkill: 4%, up to four killed in one incident; electrocutions: 13%, up to six killed in one incident). GPS coordinates were available for 61% of roadkill records and for 65% of electrocution records. Age or sex of carcasses were not available for electrocution records and only available for 11% of roadkill records. Although South Africa leads the African continent regarding roadkill and electrocution data collection, there are still areas in the collection protocol that can be improved and projects implementing mitigation measures (e.g. canopy bridges) to reduce primate roadkill are lacking. We argue that the mortality data presented here should form the basis for future mitigation implementation and recommend that linear infrastructure be more prominently recognised as a direct threat when developing national and international Red Lists.
Studying Muslim Minorities in Subsaharan Africa: Preliminary Remarks
Authors: Schulz Dorothea E.
Published: June 2022

The introduction to the special issue on Muslim minorities in Subsaharan Africa argues that a focus on the circumstances and challenges faced by them opens up productive lines of inquiry into forms of religious coexistence and plurality, in Subsaharan Africa and elsewhere. Starting from a conceptual reflection on different forms of religious plurality, the article enters a plea for more a sustained reflection on the effects of state regulation of religious coexistence and how it is lived in everyday life. To this effect, the introduction invites readers to take the different case studies of the special issue as a way to assess and compare the genealogies and legacies of state regimes of religious governance in Subsaharan Africa.
Kalanchoe sect. Raveta (Crassulaceae subfam. Kalanchooideae) of Raymond-Hamet (1916): a long-overlooked name in K. subg. Kalanchoe
Authors: SMITH GIDEON F.
Published: June 2022

The name Kalanchoe sect. Raveta (Crassulaceae subfam. Kalanchooideae, K. subg. Kalanchoe) was validly published by Raymond-Hamet in 1916, with the name being applicable to a group of seven kalanchoes from southern and south-tropical Africa. Macro-morphologically these species have large, obovate to round leaves and dense-flowered, club-shaped inflorescences. Kalanchoe thyrsiflora is here designated as the type of K. sect. Raveta.
On the distribution of Gonyosoma prasinum (Blyth, 1854) and Gonyosoma coeruleum Liu, Hou, Ye Htet Lwin, Wang & Rao, 2021, with a note on the status of Gonyosoma gramineum Günther, 1864 (Squamata: Serpentes: Colubridae)
Authors: DAVID PATRICK , CAMPBELL PATRICK D. , DEUTI KAUSHIK , HAUSER SJON , LUU VINH QUANG , NGUYEN TRUONG QUANG , ORLOV NIKOLAI , PAUWELS OLIVIER S. G. , SCHEINBERG LAUREN , SETHY PRIYADARSI GIRIJA SANKAR , SMITS TON , TEYNIÉ ALEXANDRE , VOGEL GERNOT
Published: June 2022

Based on 85 examined specimens, photographs of living specimens and illustrations published in the literature, we refine the distribution ranges of both Gonyosoma prasinum (Blyth, 1854) and of the recently described species Gonyosoma coeruleum Liu, Hou, Ye Htet Lwin, Wang & Rao, 2021, which was not clearly addressed in its original description. We also redescribe the syntypes of Coluber prasinus Blyth, 1854 and the holotype of Gonyosoma gramineum Günther, 1864, we discuss the status of this latter taxon, and we describe the hemipenial morphology of G. coeruleum.
A new primitive genus of the family Psychidae having long-scaled female antennae from the Ryukyus, Japan (Lepidoptera, Tineoidea)
Authors: SAIGUSA TOYOHEI , SUGIMOTO MIKA
Published: June 2022

The Psychid genus Lepidoceropsyche Saigusa & Sugimoto, gen. nov. and its type species Lepidoceratopsyche manoi Saigusa & Sugimoto, sp. nov. (Lepidoptera, Psychidae) are described based on the female with long-scaled antennal flagella and well-developed wings from the Ryukyus, Japan.
Taxonomic revision of the Apiomerus maya species group (Heteroptera: Reduviidae: Harpactorinae)
Authors: MASONICK PAUL , WEIRAUCH CHRISTIANE
Published: June 2022

The Apiomerus maya species group of the genus Apiomerus Hahn, 1831 (Hemiptera: Heteroptera: Reduviidae: Harpactorinae: Apiomerini), the bee assassins, is revised. Four species that are native to parts of Mexico and Central America are recognized and redescribed: Apiomerus maya Dispons, 1971, A. pipil Dispons, 1971, A. venosus Stål, 1872, and A. immundus Bergroth, 1898. Intraspecific polychromatism and male genital morphology are documented for the group. The taxonomy of two previously recognized species is updated: A. tristis Champion, 1899 syn. nov. is here synonymized with A. venosus and A. guatemalensis Dispons, 1971 syn. nov. with A. pipil.
Elevated parathyroid hormone one year after kidney transplantation is an independent risk factor for graft loss even without hypercalcemia
Authors: Okada Manabu , Tominaga Yoshihiro , Sato Tetsuhiko , Tomosugi Toshihide , Futamura Kenta , Hiramitsu Takahisa , Ichimori Toshihiro , Goto Norihiko , Narumi Shunji , Kobayashi Takaaki , Uchida Kazuharu , Watarai Yoshihiko
Published: June 2022

Background

Hypercalcemic hyperparathyroidism has been associated with poor outcomes after kidney transplantation (KTx). However, the clinical implications of normocalcemic hyperparathyroidism after KTx are unclear. This retrospective cohort study attempted to identify these implications.

Methods

Normocalcemic recipients who underwent KTx between 2000 and 2016 without a history of parathyroidectomy were included in the study. Those who lost their graft within 1 year posttransplant were excluded. Normocalcemia was defined as total serum calcium levels of 8.5–10.5 mg/dL, while hyperparathyroidism was defined as when intact parathyroid hormone levels exceeded 80 pg/mL. The patients were divided into two groups based on the presence of hyperparathyroidism 1 year after KTx. The primary outcome was the risk of graft loss.

Results

Among the 892 consecutive patients, 493 did not have hyperparathyroidism (HPT-free group), and 399 had normocalcemic hyperparathyroidism (NC-HPT group). Ninety-five patients lost their grafts. Death-censored graft survival after KTx was significantly lower in the NC-HPT group than in the HPT-free group (96.7% vs. 99.6% after 5 years, respectively, P < 0.001). Cox hazard analysis revealed that normocalcemic hyperparathyroidism was an independent risk factor for graft loss (P = 0.002; hazard ratio, 1.94; 95% confidence interval, 1.27–2.98).

Conclusions

Normocalcemic hyperparathyroidism 1 year after KTx was an independent risk factor for death-censored graft loss. Early intervention of elevated parathyroid hormone levels may lead to better graft outcomes, even without overt hypercalcemia.
Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats
Authors: Wang Liqin , Deng Haiming , Wang Tengyu , Qiao Yun , Zhu Jianbing , Xiong Mingfeng
Published: June 2022

Background

The present study aimed to determine the protective effects of hypaconitine (HA) and glycyrrhetinic acid (GA) against chronic heart failure (CHF) in the rats and to explore the underlying molecular mechanisms.

Methods

The CHF rat model was established by transverse-aortic constriction (TAC) operation. Transthoracic echocardiography and hematoxylin eosin (HE) staining were used to evaluate the pathophysiological and histopathological changes of CHF model. The total cholesterol (TCHO) and triglyceride (TG) levels were determined by ELISA assay. The protein expression of fibroblast growth factor 2 (FGF2), vascular endothelial growth factor A (VEGFA) and endothelial nitric oxide synthase (eNOS) in the rat ventricular tissues was determined by immunohistochemistry. The serum metabolites were determined by LC-MS/MS assay.

Results

After applied the HA + GA, the cardiac tissue and structure were obviously improved, and the HA + GA treatment also significantly reduced the plasma levels of TCHO and TG in the CHF rats. The expression of FGF2 and VEGFA protein was up-regulated and the expression of eNOS protein was down-regulated in the ventricular tissues of CHF rats, which was significantly restored after HA + GA treatment. HA + GA treatment down-regulated serum isonicotinic acid, phosphatidylcholine, cardiolipin, estrogen glucuronide, and glycocholic acid, up-regulated serum sphingosine and deoxycholic acid in the CHF rats.

Conclusions

In conclusion, HA + GA showed protective effects on CHF in the rats, and the HA + GA may exert protective effects by reducing lipid levels, up-regulating the expression of FGF2 and VEGFA proteins, attenuating eNOS protein expression, and modulating metabolic pathways. However, the molecular mechanisms underlying HA + GA-mediated effects still require further examination.
Developing and validating of the Clinical Uncertainty Measurement Questionnaire (CUMQ) among practicing physicians and clinical residents in Iran
Authors: Ghanavati Shirin , Baradaran Hamid Reza , Kamran Soltani Arabshahi Seyed , Bigdeli Shoaleh
Published: June 2022

Background

Despite the fact that clinicians face uncertainty in their decisions, there is no comprehensive framework to measure it in medical practices which is the knowledge gap especially for Iran. Therefore, this study aimed to evaluate the reliability and validity of a Persian questionnaire which is designed to measure different determining aspects of uncertainty from clinical physicians’ perspectives in Iran.

Methods

Clinical Uncertainty Measurement Questionnaire (CUMQ) has been derived from a mixed method study since March 2019 to January 2021. To exclude raw items of the questionnaire, the literature was reviewed and in-depthinterviews were implemented with 24 residents,specialists and sub-specialists in all major clinical fields which resulted in the first theoretical uncertainty in clinical decision making framework. CUMQ content validity has been evaluated using content validity index (CVI) and content validity ratio (CVR). The structural validity of the questionnaire was assessed using confirmatory factor analysis and factor loading and t-value for each indicator of uncertainty is reported. Moreover, to analyze the research model we used the Partial Least Squares (PLS) technique using the SmartPLS software. Convergent (using Average Variance Extracted (AVEs) for each latent variable) and discriminant validity (using the criteria of Fornell and Larckerand cross loading) of the model was also evaluated. After that, the quality of the model was evaluated adjustment through predictive validity (Q2) and effect size (f2). In addition, the reliability was also assessed using Cronbach’s alpha and composite reliability.

Results

The CVR and CVI ranged from 0. 80 to 1. 00 which illustrates high content validity. Out of 30 items, 24 items had acceptable factor loading and remained in the questionnaire which have been categorized as five main clinical uncertainty dimensions; general determinants, individual determinants of the physician, individual determinants of patient, dynamics of medical sciences, diagnostic and instrumental limitations. The value of composite reliability and Cronbach’s alpha for all dimensions were above the threshold value of 0. 7 and the reliability has been confirmed. As AVE values were greater than 0. 5, convergent validity is confirmed. The result of Fornell-Larcker and cross-loadings also indicated that discriminant validity is well established.

Conclusion

This CUMQ is as avalid and reliable instrument and a suitable tool to measure clinical uncertainty in the Iranian Medical community. However, the reliability of this questionnaire can be studied in other languages and in other countries.
Study protocol for a randomised, patient- and observer-blinded evaluation of P6 acustimulation for the prevention of nausea and vomiting in the postoperative period in patients receiving routine pharmacological prophylaxis (P6NV-Trial)
Authors: Weber Benedict , Knoth Selena , Kranke Peter , Eberhart Leopold
Published: June 2022

Background

The efficacy of pericardium 6 (P6) acupoint stimulation to reduce the incidence of postoperative nausea and vomiting (PONV) has been proven in several randomised controlled clinical trials. However, little is known about the effectiveness in daily practice and its use in combination with traditional pharmacologic approaches.

Methods

The primary objective of the P6NV study is to determine whether intraoperative acustimulation (acupuncture or acupressure) at the point P6 provides additional benefit when applied along with customary prophylactic intravenous antiemetics administered according to the local standard operating procedures (SOP). The primary endpoint is the incidence and severity of PONV within the first 24 h postoperatively reported with a validated postoperative nausea and vomiting intensity scale. The patient-reported outcome of perioperative quality of life (using the PPP33-questionnaire) and the detection of antiemetic-related side effects as well as the severity of PONV (via a standardised questionnaire) are secondary study objectives. P6NV is a national, multicentre, randomised, prospective, patient- and examiner-blinded interventional study and will be performed on 3500 adult patients with ASA classification I–III undergoing elective surgery under general anaesthesia and hospitalised for at least 24 h. Participating anaesthesiologists commit themselves to administer customised conventional antiemetic prophylaxis according to the local SOP by signing a statement before randomisation. The intervention group receives bilateral acupuncture or acupressure at P6. The control group receives no intervention. Before extubation, acustimulation is removed.

Discussion

Since P6 acustimulation is performed by a wide range of anaesthesiologists receiving written and verbal information on acustimulation beforehand, this trial will provide information on the effectiveness of an ad hoc implementation of P6 stimulation techniques in anaesthesia departments using traditional pharmacologic PONV prophylaxis.

Trial registration

DRKS DRKS00015272. Registered on August 15, 2018.
Final Overall Survival Analysis of Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma: A Multicenter, Randomized Phase III Trial
Authors: Zhang Yuan , Chen Lei , Hu Guo-Qing , Zhang Ning , Zhu Xiao-Dong , Yang Kun-Yu , Jin Feng , Shi Mei , Chen Yu-Pei , Hu Wei-Han , Cheng Zhi-Bin , Wang Si-Yang , Tian Ye , Wang Xi-Cheng , Sun Yan , Li Jin-Gao , Li Wen-Fei , Li Yu-Hong , Mao Yan-Ping , Zhou Guan-Qun , Sun Rui , Liu Xu , Guo Rui , Long Guo-Xian , Liang Shao-Qiang , Li Ling , Huang Jing , Long Jin-Hua , Zang Jian , Liu Qiao-Dan , Zou Li , Su Qiong-Fei , Zheng Bao-Min , Xiao Yun , Guo Ying , Han Fei , Mo Hao-Yuan , Lv Jia-Wei , Du Xiao-Jing , Xu Cheng , Liu Na , Li Ying-Qin , Xie Fang-Yun , Sun Ying , Ma Jun , Tang Ling-Long
Published: June 2022

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically on the based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.

We previously reported significantly improved failure-free survival using gemcitabine plus cisplatin induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma. Here, we present the final overall survival (OS) analysis. In this multicenter, randomized trial, patients were assigned to be treated with concurrent chemoradiotherapy alone (standard therapy, n = 238) or gemcitabine and cisplatin induction chemotherapy before concurrent chemoradiotherapy (n = 242). With a median follow-up of 69.8 months, the induction chemotherapy group had a significantly higher 5-year OS (87.9% v 78.8%, hazard ratio, 0.51 [95% CI 0.34 to 0.78]; P = .001) and a comparable risk of late toxicities (≥ grade 3, 11.3% v 11.4%). Notably, the depth of the tumor response to induction chemotherapy correlated significantly and positively with survival (complete response v partial response v stable/progressive disease, 5-year OS, 100% v 88.4% v 61.5%, P = .005). Besides, patients with a low pretreatment cell-free Epstein-Barr virus DNA load (< 4,000 copies/mL) might not benefit from induction chemotherapy (5-year OS, 90.6% v 91.4%, P = .77). In conclusion, induction chemotherapy before concurrent chemoradiotherapy improved OS significantly in patients with locally advanced nasopharyngeal carcinoma, without increasing the risk of late toxicities. Tumor response to induction chemotherapy and pretreatment cell-free Epstein-Barr virus DNA might be useful to guide individualized treatment.
Effect of Extracellular Matrix Density and Cell Number on Blood Capillary Formation in Three-Dimensional Tissue
Authors: Shang Yucheng , Zeng Jinfeng , Xie Zhengtian , Sasaki Naoko , Matsusaki Michiya
Published: June 2022

The construction of three-dimensional (3D) capillary tissue is still a central issue in the field of tissue engineering. To improve the vascularization of 3D tissue, elements including growth factors and scaffold type have been found to affect the construction of 3D capillary structures. However, the effect of other factors such as modulus or cell number on blood capillaries remains unclear.

In this work, a high-throughput 3D-human blood capillary model was fabricated via sedimentary culture method, based on 3D culture of endothelial cells and fibroblasts with the support of collagen microfibers (CMFs) as an extracellular matrix. The amount of CMF or cell number was varied to evaluate the relationship between tissue modulus and blood capillary length. Although varying the amount of CMF did not significantly affect these factors, the numbers of fibroblasts and endothelial cells indicated a huge impact on the modulus of tissues and the length of blood capillaries. These findings provide an important basic knowledge of blood capillary formation in 3D tissue in the field of 3D tissue engineering.
Προγνωστική σημασία ηλεκτροκαρδιογραφικών δεικτών και όψιμων δυναμικών σε ασθενείς με ισχαιμική καρδιομυοπάθεια και μικρή-μέτρια έκπτωση συστολικής λειτουργίας αριστερής κοιλίας
Authors: Τσίμος Κωνσταντίνος
Published: June 2022

Εισαγωγή: Οι αναίμακτοι ηλεκτροκαρδιογραφικοί δείκτες διαστρωμάτωσης κινδύνου (ΑΔΔΚ) διαδραματίζουν σημαντικό ρόλο στη διαστρωμάτωση του αρρυθμιολογικού κινδύνου ασθενών μετά από έμφραγμα του μυοκαρδίου (ΕΜ) με διατηρημένο ή ήπια μειωμένο κλάσμα εξώθησης αριστερής κοιλίας (ΚΕΑΚ). Ωστόσο, η συγκεκριμένη σχέση τους με τη συστολική λειτουργία της αριστερής κοιλίας παραμένει ασαφής. Στόχος μας ήταν να αξιολογήσουμε τη συσχέτιση μεταξύ των ΑΔΔΚ και του ΚΕΑΚ στους ασθενείς που συμπεριλήφθηκαν στη μελέτη PRESERVE-EF.Μέθοδος: Μελετήσαμε 575 ασθενείς μετεμφραγματικούς ασθενείς χωρίς υπολειπόμενη ισχαιμία και ΚΕΑΚ ≥ 40% (μέση ηλικία: 57,0 ± 10,4 έτη, 86,2% άνδρες). Αξιολογήθηκαν οι ακόλουθοι ΑΔΔΚ: έκτακτες κοιλιακές συστολές (ΕΚΣ), μη εμμένουσα κοιλιακή ταχυκαρδία (ΜΕΚΤ), όψιμα δυναμικά (ΟΔ), παρατεταμένο QTc διάστημα, παθολογικές εναλλαγές Τ κυμάτων (ΕΤΚ), μειωμένη μεταβλητότητα καρδιακής συχνότητας (ΜΚΣ), μη φυσιολογική ικανότητα επιβράδυνσης (ΙΕΚΡ) και μη φυσιολογικό στροβιλισμό της καρδιακής συχνότητας (ΣΚΣ).Αποτελέσματα: Υπήρξε μια στατιστικά σημαντική συσχέτιση μεταξύ των ΟΔ (chi-squared = 4.975; p < 0.05), ΜΕΚΤ (chi-squared =5.749, p < 0.05), ΕΚΣ (r= - 0.136; p < 0.01) και του κλάσματος εξώθησης αριστερής κοιλίας. Η πολυπαραγοντική ανάλυση γραμμικής παλινδρόμησης έδειξε ότι τα παθολογικά ΟΔ (p = 0,001) και η ΜΕΚΤ (p < 0,001) ήταν σημαντικοί προγνωστικοί παράγοντες του ΚΕΑΚ σε αυτούς τους μετεμφραγματικούς ασθενείς. Τα αποτελέσματα της πολυπαραγοντικής ανάλυσης λογιστικής παλινδρόμησης έδειξαν ότι τα ΟΔ (OR: 1,76; 95% CI: 1,02-3,05; p = 0,004) και η ΜΕΚΤ (OR: 2,44; 95% CI: 1,18-5,04; p = 0,001) ήταν ανεξάρτητοι προγνωστικοί παράγοντες του διωνυμικού ΚΕΑΚ, δηλαδή προγνωστικοί παράγοντες του ήπια μειωμένου ΚΕΑΚ 40-49% έναντι του διατηρημένου ΚΕΑΚ ≥ 50%. Η ανάλυση της καμπύλης ROC έδειξε ότι η επιφάνεια κάτω από την καμπύλη (AUC) για τη ΜΕΚΤ ήταν 0,671 (p < 0,01) και 0,609 για τα ΟΔ (p < 0,01).Συμπέρασμα: Τα παθολογικά ΟΔ και η ΜΕΚΤ σχετίζονται ανεξάρτητα με το μειωμένο ΚΕΑΚ ενώ είναι ανεξάρτητοι προγνωστικοί παράγοντες του διωνυμικού ΚΕΑΚ δηλαδή προγνωστικοί παράγοντες του ήπια μειωμένου έναντι του διατηρημένου ΚΕΑΚ. Αυτά τα ευρήματα μπορεί να έχουν σημαντικές επιπτώσεις για τη διαστρωμάτωση του αρρυθμιολογικού κινδύνου των ασθενών μετά από έμφραγμα μυοκαρδίου με ήπια μειωμένη ή διατηρημένη συστολική λειτουργία αριστερής κοιλίας.
Didactic Word Games As a Means of Developing Communicative Universal Educational Activities in Younger Schoolchildren
Authors: Kreslavskaya T.
Published: June 2022

The article discusses the problem of implementing the requirements of the Federal State Educational Standard of Primary General Education for the formation of universal educational activities for younger students. The influence of didactic word games on the formation of the ability of younger students to communicate productively with peers is considered: to raise questions, discuss joint actions, take into account the characteristics and interests of partners in the game. Examples of didactic word games are given that contribute to the formation of three types of communication: interaction with a partner; taking into account the position of the interlocutor or partner in activities; communication aimed at ensuring cooperation.
Formation of Prerequisites for Educational Independence of First-Graders in Mathematics Lessons
Authors: Izikaeva M.
Published: June 2022

The article deals with the actual problem of the formation of educational independence of younger schoolchildren using the means of mathematics, the approaches of various Russian scientists to the organization of this process are revealed. The author gives a description of the concept of "learning independence", gives examples of tasks that contribute to the development of all components of the independence of first grade students.
Evaluation of the Planned Learning Outcomes for the Subject "Fundamentals of Religious Cultures and Secular Ethics"
Authors: Vinogradova Natalya
Published: June 2022

The publication provides an explanation regarding the construction by the teacher of a system for monitoring and evaluating the planned educational results of fourth-graders when they master the content of the subject “Fundamentals of Religious Cultures and Secular Ethics” (FRCSE). The question of an elementary school teacher from Khabarovsk is answered by Doctor of Pedagogical Sciences, professor N.F. Vinogradova. In accordance with the provisions of the Law "On Education in the Russian Federation", an educational organization has the right to independently choose a system for current monitoring of progress, intermediate certification, as well as the forms, frequency and procedure for its implementation. Recommendations for the organization of monitoring activities are contained in the updated Federal State Educational Standard for Primary General Education. The publication explains in detail the features of the teacher's assessment of subject, meta-subject and personal achievements of fourth grade students in connection with the originality of the subject of the FRCSE.
When Do Evaluators Publicly Express Their Legitimacy Judgments? An Inquiry into the Role of Peer Endorsement and Evaluative Mode
Authors: van den Broek Tijs , Langley David J. , Ehrenhard Michel L. , Groen Aard
Published: June 2022

Legitimacy theory describes how individuals evaluate an organization’s behavior, form propriety evaluations, and subsequently decide whether to publicly express their legitimacy judgments. These individual judgments are influenced by sources of collective validity, for example, from recognized authority or from peer endorsement. Whereas most research on this topic has focused on the effects of authority, we study the influence of peer endorsement on the public expression of legitimacy judgments. Additionally, we assess evaluators’ preparedness to expend cognitive effort, that is, their evaluative mode, as an important condition under which judgment expressions are made. We present a set of three vignette experiments and one field study, all situated in social media that are quickly becoming the dominant setting for the expression of legitimacy judgments. This research provides new evidence that peer endorsement stimulates evaluators to express their judgments, particularly for evaluators who expend limited cognitive effort. Additionally, we find that evaluators in the active and passive evaluative modes act differently when their propriety evaluations are based on instrumental, moral, or relational considerations. These findings extend current legitimacy theory about how peer endorsement functions as a source of validity and when individual evaluators decide to publicly express their legitimacy judgments. This is important because individuals’ public expressions can bring about a cascade of judgments that change the consensus on an organization’s legitimacy, potentially contributing to institutional change.

History: This paper has been accepted for the Organization Science Special Issue on Experiments in Organizational Theory.

Supplemental Material: The online appendices are available at https://doi.org/10.1287/orsc.2022.1604 .
Quality Evaluation of Hot Air-Dried Edible Insect ‘Protaetia Brevitarsis Larvae’ Including Sacrificing Method, Storage Temperature, and Defatting Condition
Authors: Kim Ha Young , Kim Duri , Chun Ji-Yeon
Published: June 2022

This study evaluated the Protaetia brevitarsis larvae powder’s characteristic changes using hot air drying (60±2.5°C, 12 h) with different pre-treatment methods, including two sacrifice methods, two storage temperatures, and two defatting processes. Appearance, yield, moisture contents, pH, color, proximate analysis, volatile basic nitrogen level, DPPH radical scavenging activity, and total phenol content were assessed. Results revealed that a combination of blanching, defatting, and -20°C storage temperature resulted in higher total phenol contents, lower water contents, and lower volatile basic nitrogen levels than other methods. Defatted treatment resulted in a higher L-value than the non-defatted treatment. Taken together, these results indicate that a combination of -20°C storage, blanching, and defatting is the optimal pre-treatment method for obtaining P. brevitarsis larvae powder with high total phenol content, low water content, and low volatile basic nitrogen, taking into account cost efficiency considerations.
Effects of Partial Substitution of Melissa Officinalis Powder on Muffin Quality Characteristics
Authors: Lee Jun Ho
Published: June 2022

To develop quality-improved muffins, the influence of the partial replacement of wheat flour with lemon balm powder (LBP) on their quality characteristics was analyzed. Studies were carried out to examine the supplementation of different percentages of LBP (2%, 4%, 6%, and 8%) on the quality characteristics of LBP muffins. The incorporation of LBP significantly affected the physicochemical parameters of muffins. Such incorporation at different levels significantly decreased pH, moisture content, baking loss, hardness, and color parameters, including L*, a*, and b* values of muffins (p<0.05). No significant effect of LBP substitution was found in height changes (p>0.05). Finally, the consumer acceptance test indicated that the highest levels of LBP incorporation (i.e., 8%) had a considerably adverse effect on consumer preferences in all attributes. In contrast, muffins with moderate levels of LBP (4%) showed a good and satisfactory sensorial acceptance in general. Thus, LBP was successfully employed in muffins, improving quality and broadening its potential applications in other bakery products.
Spatial distribution of mangrove vegetation species, salinity, and mud thickness in mangrove forest in Pangarengan, Cirebon, Indonesia
Authors: PURWANTO RIS HADI , MULYANA BUDI , SATRIA RYAN ADI , YASIN EMAD HASSAN ELAWAD , PUTRA ILHAM SATRIA RADITYA , PUTRA AGIK DWIKA
Published: June 2022

Abstract. Purwanto RH, Mulyana B, Satria RA, Yasin EHE, Putra ISR, Putra AD. 2022. Spatial distribution of mangrove vegetation species, salinity, and mud thickness in mangrove forest in Pangarengan, Cirebon, Indonesia. Biodiversitas 23: 1384-1392. The mangrove rehabilitation programs in the northern coastline of West Java showed varying levels of success due to the lack of information on habitat suitability and species distribution. This research aimed to investigate the spatial distribution of mangrove vegetation species, salinity, and mud thickness in Pangarengan mangrove forest, Cirebon, Indonesia. Data on mangrove vegetation, salinity, and mud thickness were collected from 78 randomly distributed sample plots. Species composition was analyzed using important value index, and spatial distribution was examined using QGIS. Results revealed that Rhizophora mucronata was the most dominant and widely distributed species in all areas of Pangarengan mangrove forest with the important value index (IVI) for seedlings, saplings, poles, and trees were 178.69%, 219.71%, 242.21%, and 167.56%, respectively. Avicennia marina showed significant IVI in saplings (59.41%) and trees (105.21%). Other species had an IVI of less than 20% for each growth stage. Salinity ranged from 0-28 ppt and gradually decreased from the shoreline to settlement areas. Mud thickness ranged from 55 to 175 cm but with no regular pattern observed. In conclusion, the Pangarengan mangrove forest was dominated by R. mucronata. Our findings suggest that to enhance the likelihood of success in mangrove rehabilitation programs, R. mucronata might be a good choice, but to increase the species diversity other species might need to be planted by applying specific treatments, such as a vertical aquaponic system.
Diseños de rúbricas de proyectos de aprendizaje-servicio en el ámbito de la actividad física y del deporte: una revisión narrativa
Authors: Campos-Rius Josep , Franco-Sola Marc , Figueras Sara , Lleixà Teresa
Published: June 2022

El artículo tiene por objetivo presentar una revisión narrativa de los diseños de rúbricas de evaluación en proyectos de aprendizaje-servicio para establecer una fundamentación aplicable al ámbito de la actividad física y el deporte. El análisis de las bases de datos nacionales e internacionales utilizadas tienen en cuenta la literatura científica desarrollada sobre el tema entre los años 2017 y 2021. Se obtuvieron 49 resultados de los cuales se seleccionaron 18 publicaciones. La mayor parte de las rúbricas analizadas tienen un carácter general para aplicar en las diferentes etapas educativas y, sobre todo, en la formación universitaria. Los objetivos de las rúbricas se centran en la evaluación (o autoevaluación) de la calidad de la implementación de proyectos de aprendizaje-servicio y sobre el rol de los interlocutores que participan en ellos. Las rúbricas tienen diversos formatos en función del objetivo planteado. Se concluye la necesidad de ampliar los estudios, y por consiguiente también la literatura, sobre las rúbricas destinadas a la evaluación de otros aspectos relevantes como podrían ser la calidad del servicio generado o la calidad del aprendizaje profundo y transformador.
Efecto de una experiencia de aprendizaje-servicio en la formación de maestras de Educación Infantil
Authors: Sáez-Gallego Nieves María
Published: June 2022

El aprendizaje-servicio ha sido utilizado en la formación de docentes de diferentes especialidades y etapas educativas para favorecer su desarrollo competencial, entre las que se incluye su aplicación en contextos reales de enseñanza de la Educación Física (EF). El objetivo del presente trabajo es evaluar el efecto de una experiencia de ApS basada en el diseño y puesta en práctica de actividades motrices en la formación de maestras de Educación Infantil. 44 futuras maestras de EI participaron en la experiencia y registraron su valoración en un autoinforme sobre las emociones suscitadas, los resultados de aprendizaje y la percepción de la actitud de los niños que han recibido el servicio. La experiencia consistía en la puesta en práctica de una sesión de EF para una clase de 4 y 5 años, diseñada a partir del desarrollo de una actividad de aprendizaje basado en problemas. Entre las conclusiones extraídas cabe destacar que la experiencia propició la experimentación de emociones mayoritariamente positivas en las participantes como la satisfacción, la alegría y la felicidad, y las ha motivado para continuar sus estudios. Asimismo, el ApS les permitió realizar una reflexión crítica sobre su propia práctica y obtener retroalimentación respecto a diferentes aspectos de la función docente como el diseño de actividades, la organización de la sesión o el control de la clase. Por último, las participantes han percibido una actitud participativa de niños y niñas que han recibido el servicio, lo que ha propiciado el aumento de bagaje de experiencias motrices.
Prediction and expression analysis of deleterious nonsynonymous SNPs of Arabidopsis ACD11 gene by combining computational algorithms and molecular docking approach
Authors: Rifat Mahmudul Hasan , Ahmed Jamil , Ahmed Milad , Ahmed Foeaz , Gulshan Airin , Hasan Mahmudul
Published: June 2022

Accelerated cell death 11 (ACD11) is an autoimmune gene that suppresses pathogen infection in plants by preventing plant cells from becoming infected by any pathogen. This gene is widely known for growth inhibition, premature leaf chlorosis, and defense-related programmed cell death (PCD) in seedlings before flowering in Arabidopsis plant. Specific amino acid changes in the ACD11 protein’s highly conserved domains are linked to autoimmune symptoms including constitutive defensive responses and necrosis without pathogen awareness. The molecular aspect of the aberrant activity of the ACD11 protein is difficult to ascertain. The purpose of our study was to find the most deleterious mutation position in the ACD11 protein and correlate them with their abnormal expression pattern. Using several computational methods, we discovered PCD vulnerable single nucleotide polymorphisms (SNPs) in ACD11. We analysed the RNA-Seq data, identified the detrimental nonsynonymous SNPs (nsSNP), built genetically mutated protein structures and used molecular docking to assess the impact of mutation. Our results demonstrated that the A15T and A39D mutations in the GLTP domain were likely to be extremely detrimental mutations that inhibit the expression of the ACD11 protein domain by destabilizing its composition, as well as disrupt its catalytic effectiveness. When compared to the A15T mutant, the A39D mutant was more likely to destabilize the protein structure. In conclusion, these mutants can aid in the better understanding of the vast pool of PCD susceptibilities connected to ACD11 gene GLTP domain activation.
Determination of the optimal working performance matching through theoretical analysis and experimental study for a screw conveyor
Authors: Mei Xiao , Xue Yukun , Zhang Lanlan
Published: June 2022

An experiment was conducted to investigate the effect of screw speed, feeding head speed, and the nature and type of granular material on the productivity and power consumption of a screw conveyor, and then determine the optimal speed. This experiment contains two parts. Part one was designed with 11 levels of screw speed (100-600r/min, interval 50r/min), three levels of feeding head speed (60,80 and 100r/min), and two kinds of granular materials (fine sand and soybeans). Part two was designed with 11 levels of screw speed (20-140r/min, interval 20r/min), three levels of feeding head speed (300,400 and 500r/min), and two kinds of granular materials (fine sand and soybeans). The results indicated that with the increase of the screw speed, the conveying performance will not always get better; with the rise of the feeding head speed, the conveying performance will get better. Due to the higher bulk density of sand, the productivity of conveying sand is higher for granular materials. Finally, for sand, the result indicates when the screw speed is 400r/min, and the feeding head speed is 120r/min, the conveying performance of sand determined by the productivity and power consumption is the best; for soybean, when the screw speed is 300r/min, and the feeding head speed is 140r/min, the conveying performance is the best.
AlphaFold2 and RoseTTAFold predict posttranslational modifications. Chromophore formation in GFP-like proteins
Authors: Hartley Sophia M. , Tiernan Kelly A. , Ahmetaj Gjina , Cretu Adriana , Zhuang Yan , Zimmer Marc
Published: June 2022

AlphaFold2 and RoseTTAfold are able to predict, based solely on their sequence whether GFP-like proteins will post-translationally form a chromophore (the part of the protein responsible for fluorescence) or not. Their training has not only taught them protein structure and folding, but also chemistry. The structures of 21 sequences of GFP-like fluorescent proteins that will post-translationally form a chromophore and of 23 GFP-like non-fluorescent proteins that do not have the residues required to form a chromophore were determined by AlphaFold2 and RoseTTAfold. The resultant structures were mined for a series of geometric measurements that are crucial to chromophore formation. Statistical analysis of these measurements showed that both programs conclusively distinguished between chromophore forming and non-chromophore forming proteins. A clear distinction between sequences capable of forming a chromophore and those that do not have the residues required for chromophore formation can be obtained by examining a single measurement—the RMSD of the overlap of the central alpha helices of the crystal structure of S65T GFP and the AlphaFold2 determined structure. Only 10 of the 578 GFP-like proteins in the pdb have no chromophore, yet when AlphaFold2 and RoseTTAFold are presented with the sequences of 44 GFP-like proteins that are not in the pdb they fold the proteins in such a way that one can unequivocally distinguish between those that can and cannot form a chromophore.