bluuebunny/crossref_metadata_2025 huggingface dataset:
A Farewell to Vienna
Authors: Korngold Luzi , Karnes Kevin C.
Published: May 2020

This chapter contains some reflections by Luzi Korngold, wife to Erich Korngold. In her first published statement on her life with Erich, Luzi recounted the start of their relationship, concisely and directly and in the third person. “In the spring of 1917, Erich got to know his future wife, Luzi Sonnenthal, granddaughter of the court actor Adolf Ritter v. Sonnenthal. From the very first meeting, there developed between these two young people a friendship and sense of connectedness that was unbreakable and would endure throughout their lives.” More than anything else, Luzi's memoir of the journeys she shared with Erich in 1935–1938 testifies to her experience of that sense of friendship and connectedness, of the experience of a family whose destiny was altered by forces they could not control, but through which they endured.
Composing for the Pictures: An Interview
Authors: Goldmark Daniel
Published: May 2020

This chapter provides an interview conducted by noted composer and librettist Verna Arvey for The Etude Music Magazine. Arvey's identifying Korngold from the start as “the Viennese composer” shows that he had not yet become as closely associated with film as he would by decade's end. Indeed, much of the article focuses on the shifting place of music in the contemporary world (this being 1936), including the incredible suggestion—for the age—that film music was developing as a genre unto itself. Even with Korngold as one of its most visible and acclaimed practitioners, film music was still roundly disdained or ignored by music critics, who denied its status as a legitimate compositional form. Indeed, Korngold's eventual turn to composing film music full-time during the war years led many critics to accuse him of having “sold out.” And while Arvey and others still looked at his work in film as a lark or even a whim, Korngold took it quite seriously.
Faith in Music!
Authors: Korngold Erich Wolfgang , Karnes Kevin C.
Published: May 2020

This chapter contains Erich Korngold's last published statement on music. In it he made no mention of his own. Written in October 1955, less than half a year after what would turn out to be his final, dispirited return from Europe, “Faith in Music!” recapitulates a position he outlined in “Notes for an Interview.” However, he updates it for the postwar world, with its collective witness to what had recently been the unimaginable, technologized violence of the interceding years. Against the backdrop of his critical failures in Austria and West Germany, and recasting his apology for the untimeliness of all great works of music, he wrote: “The true creative artist does not wish to recreate for his fellow man the headlines screaming of atom bombs, murder, and sensationalism found in the daily paper.”
Before and After Auschwitz: Korngold and the Art and Politics of the Twentieth Century
Authors: Botstein Leon
Published: May 2020

This chapter discusses Erich Korngold's changing status as a composer in the twentieth century. Since the early 1970s, spurred by popular modern recordings of Korngold's film music and the embrace of the Violin Concerto as a favored vehicle by a new generation of aspiring violinists, both Korngold's career as a composer and his output have gained in currency and respectability. Korngold's posthumous good fortune is the unanticipated consequence of the return to legitimacy, at the end of the twentieth century, of an aesthetic eclecticism regarding contemporary music. The belief in the exclusive legitimacy of an aesthetics of a radical modernism—justified by history, for the postwar world—has vanished. Minimalism, a new Romanticism, the integration with forms of popular music, and the blurring of genre distinctions all can be found in the music composed during the last forty years. These have turned Korngold from marginal figure into a prominent representative of the twentieth century, alongside other unjustly forgotten composers of a more “conservative” character.
Chantaje colonial e ilegitimidad institucional occidental. La vigencia de lo común en la región latinoamericana
Authors: Villa Holguín Edison
Published: May 2020

Esta reflexión pretende visualizar algunos elementos y características de lo que se ha nombrado actualmente como el agotamiento de la racionalidad constitutiva de lo que fue conocido como “el proyecto político de la modernidad”. Para el caso latinoamericano, la institucionalidad política, acuñada al sistema democrático de occidente, en lugar de ser solución termina agudizando el contexto de dominación e injusticia. Al presente, “las repúblicas democráticas”, en la región latinoamericana, no han sido los espacios esperados de trámite de las contradicciones del propio sistema. El siguiente argumento, en perspectiva crítica, intenta aportar al actual debate político nombrando algunos desafíos para las teorías políticas que buscan superar el pensamiento único, hoy reducido al economicismo hegemónico que hace ilegítimo el estado, en la búsqueda de otros proyectos de sociedad para el siglo XXI.
La reconciliación en el posacuerdo, un proceso psicosocial y comunitario basado en experiencias en el Chocó
Authors: Beltrán Espitia Manuel
Published: May 2020

El presente artículo se construyó como proceso reflexivo en torno a la reconciliación desde las experiencias trabajadas de forma mancomunada entre la Fundación Universitaria Claretiana y las organizaciones étnico territoriales que hacen presencia en el departamento del Chocó, lo cual se fortalece en las investigaciones de carácter social para la búsqueda de la comprensión, la articulación y el desarrollo, en la posibilidad de una reconciliación entre las diferentes poblaciones y en la idea fundamental de construir puentes de convergencia hacia una paz estable y duradera.
Asociaciones Público Privadas en la actividad contractual: nuevo modelo de gestión pública dirigido a la concreción de los fines del Estado
Authors: Henao Jaramillo Jennifer
Published: May 2020

El presente trabajo analiza el esquema de las Asociaciones Público Privadas (APP) consagradas en la ley 1508 de 2012, como un instrumento de vinculación del capital privado y modalidad de gestión pública dentro de la actividad contractual. Para ello, se propone resaltar aspectos esenciales de las mismas que permitan responder a la pregunta: ¿Cuál es la importancia de las app como modelo de gestión pública en la actividad contractual, para la concreción de los fines del Estado? La finalidad se cimienta en analizar la importancia de estas como esquemas y herramientas de gestión pública dirigidas al cumplimiento de los fines del Estado, desde el elemento cuantitativo del Estado Social de Derecho, en especial desde el fin de servicio a la comunidad, proponiéndose ahondar en la normatividad vigente colombiana que versa en torno a las mismas, donde se vislumbra la importancia de estas estructuras y se detallan las diferencias entre los esquemas de iniciativa privada como verdadera novedad e iniciativa pública.
Comparison of the efficacy and duration of desensitization of oral structures following injection of various volumes of a lidocaine-bupivacaine mixture via an infraorbital approach in dogs
Authors: Pascoe Peter J. , Chohan Amandeep S.
Published: May 2020

OBJECTIVE

To compare the efficacy and duration of desensitization of oral structures following injection of various volumes of lidocaine-bupivacaine via an infraorbital approach in dogs.

ANIMALS

6 healthy adult hound-type dogs.

PROCEDURES

In a randomized crossover study, each dog received 1, 2, and 3 mL of a 2% lidocaine-0.5% bupivacaine mixture (50:50 vol/vol) injected within and near the caudal aspect of the infraorbital canal with a 14-day washout period between treatments. Dogs were anesthetized, and each treatment was administered through a 22-gauge, 4.5-cm-long catheter, which was fully inserted through and then withdrawn 2 cm to the caudal aspect of the infraorbital canal. The reflex-evoked motor potential was measured for the maxillary canine tooth (MC), fourth premolar tooth (MPM4), second molar tooth (MM2), and hard palate mucosa ipsilateral to the injected treatment and for the contralateral MC (control) at predetermined times before and for 6 hours after treatment administration or until the block was no longer effective. For each oral structure, the proportion of dogs with desensitization (efficacy) and time to onset and duration of desensitization were compared among the 3 treatments (injectate volumes).

RESULTS

Treatment was not associated with efficacy, time to onset, or duration of desensitization. Regardless of treatment, MC and MPM4 were more frequently desensitized and mean durations of desensitization for MC and MPM4 were longer, compared with those for MM2 and the hard palate.

CONCLUSIONS AND CLINICAL RELEVANCE

The volume of local anesthetic used for an infraorbital nerve block had no effect on block efficacy or duration.
Effect of packed red blood cell transfusion on thromboelastographic tracings in dogs with naturally occurring anemia
Authors: Brooks Aimee C. , Cooper Edward S. , Couto C. Guillermo , Guillaumin Julien
Published: May 2020

OBJECTIVE

To assess the effect of packed RBC (pRBC) transfusion on thromboelastographic (TEG) tracings in dogs with naturally occurring anemia.

ANIMALS

22 clinically anemic dogs that received a pRBC transfusion.

PROCEDURES

For each dog, a blood sample was collected before and within 3 hours after completion of the pRBC transfusion for a CBC, nonactivated TEG analysis, and measurement of blood viscosity. Wilcoxon signed rank tests were used to compare CBC, viscosity, and TEG variables between pretransfusion and posttransfusion blood samples. Multivariable linear regression was used to assess the effects of pretransfusion-posttransfusion changes in Hct, WBC count, and platelet count on changes in TEG variables.

RESULTS

Median posttransfusion Hct (21%; range, 13% to 34%) was significantly greater than the median pretransfusion Hct (12.5%; range, 7% to 29%). Packed RBC transfusion was associated with a median increase in Hct of 6.2% (range, 1.2% to 13%). Maximum amplitude significantly decreased from 74.9 to 73.8 mm and clot strength significantly decreased from 14,906 to 14,119 dynes/s after pRBC transfusion. Blood viscosity significantly increased, whereas platelet and WBC counts significantly decreased after transfusion. Multivariable linear regression revealed that pretransfusion-posttransfusion changes in Hct, WBC count, and platelet count were not associated with changes in TEG variables.

CONCLUSIONS AND CLINICAL RELEVANCE

Results indicated that pRBC transfusion had only small effects on the TEG tracings of hemodynamically stable dogs. Therefore, large changes in TEG tracings following pRBC transfusion are unlikely to be the result of the transfusion and should be investigated further.
AYAM LEHER GUNDUL: SEJARAH, KARAKTERISTIK, DAN KONSERVASI
Authors: T. Kostaman
Published: May 2020

Ayam leher gundul adalah ayam asli/lokal Indonesia yang belum banyak diketahui informasinya dalam halsejarah, potensi, dan karakteristik; sehingga belum dimanfaatkan secara optimal. Ciri yang paling menonjoldari ayam leher gundul adalah tidak mempunyai bulu dibagian lehernya. Untuk mempertahankannya, metode konservasi yang telah dilakukan oleh Balai Penelitian Ternak (Balitnak) adalah dengan memelihara ternak hidup, akan tetapi dengan keterbatasan sarana dan prasarana tidak dapat dilanjutkan. Data performan ayam leher gundul yang dipelihara di Balitnak sudah terkumpul dan ditabulasi. Alternatif konservasi yang dilakukan oleh Balitnak untuk mempertahankan plasma nutfah ayam leher gundul adalah berupa primordial germ cell (PGC) yang dibekukan pada suhu -196 oC yang sewaktu-waktu dibutuhkan dapat ditransfer ke embrio resipien. Sumber PGC yang di koleksi adalah dari darah dan gonad embrio. Berdasarkan potensi yang dimilikinya, ayam leher gundul memiliki performan yang baik, sehingga dapat dimanfaatkan sebagai ayam lokal penghasil daging dan telur. Tulisan ini diharapkan dapat bermanfaat sebagai data pendukung bagi upaya pelestarian dan pengembangan ayam-ayam lokal yang ada di Indonesia, khususnya ayam leher gundul dan umumnya ayam-ayam lokal Indonesia lainnya.
PENAMPILAN PEDET SAPI BALI HASIL INSEMINASI BUATAN DARI PEJANTAN BERBEDA
Authors: M. Dewantari , Oka A. A.
Published: May 2020

Inseminasi Buatan (IB) adalah salah satu teknologi reproduksi yang telah berhasil meningkatkan mutu genetik ternak, dan dalam waktu pendek dapat menghasilkan anak dengan kualitas baik dalam jumlah yang besar dengan memanfaatkan pejantan unggul. Penelitian ini bertujuan untuk mengetahui penampilan pedet sapi bali hasil inseminasi buatan dari pejantan yang berbeda. Penelitian menggunakan data primer dan sekunder. Data sekunder berupa catatan berat lahir sapi hasil inseminasi buatan dan data primer merupakan pengukuran berat dan dimensi tubuh anak-anak sapi hasil inseminasi buatan dari pejantan berbeda. Statistik deskriptif digunakan untuk membantu memaparkan keadaan yang sebenarnya dari potensi produksi pejantan yang dipakai sebagai sumber semen sehingga diperoleh data dasar tentang potensi produksi. Hasil penelitian menunjukkan bahwa tidak ada perbedaan bobot lahir pedet sapi dari pejantan berbeda, demikian juga terhadap bobot dan dimensi tubuh pedet sapi pra sapih hasil inseminasi buatan dari pejantan berbeda. Kesimpulan dari penelitian ini bahwa pejantan yang digunakan dalam penelitian ini mempunyai kualitas yang sama.
THE EFFECT OF SINGLE- AND REPEATED- EXCESSIVE SWIMMING EXERCISE ON KIDNEY HISTOPATHOLOGY OF MALE RATS WISTAR STRAIN (Rattus norvegicus)
Authors: Tripani Wenni Juniarni , Ilmiawan Muhammad In’am , Handoko Willy
Published: May 2020

Background: Physical exercise aims to improve or maintain physical fitness. However, excessive physical exercise may cause increase of oxidative stress which leads to cellular injury, including in the proximal tubules of kidney. This research aims to find out the effect of single- and repeated- excessive swimming exercise to the kidney histopathology of male wistar rats (Rattus norvegicus). Methods: This research was an experimental study with complete random and post test only control group design. Twenty seven male wistar rats were divided into three treatment groups: control group, single- excessive swimming exercise group (45 minutes for one day), and repeated- excessive swimming exercise group (45 minutes/day for seven days). In the end of the treatment, the kidney of the rats were taken to be analyzed by using hematoxylin-eosin stain. The mean of proximal tubules injury of kidneys were counted by two observers using blinded method. Data were analyzed by using one way anova test. Result: The analysis showed there was a significant difference in the mean percentage of proximal tubules injury between control group and single swimming group as well as the repeated swimming group (Anova p=0,000), also there was significant difference between the treatment groups (p=0,020). The highest average of proximal tubules injury was in the single swimming group. Conclusion: Single- and repeated- excessive swimming exercise causes the proximal tubules injury of kidney.
Pengaruh Earning Per Share, Debt To Equity Ratio dan Price Earning Ratio Terhadap Harga Saham Perusahaan Sektor Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia Periode 2013 – 2017
Authors: Agustinus Arie , Firdausy Carunia Mulya
Published: May 2020

The purpose of this research is to find out the influence of Earning Per Share, Debt to Equity Ratio, and Price Earning Ratio on the stock price of food and beverage companies listed in the Indonesia Stock Exchange for the period 2013 to 2017. The research sample consists of 12 companies, that were selected by using a purposive technique sampling method for the period of 2013-2017. The method to analyse the research questions was by using the statistical method of multiple linear regression method. The result found that Earning Per Share and Price Earning Ratio partially have significant influences on the stock price. Whilst Debt to Equity Ratio partially doesn’t have a significant influence. However, Earning Per Share, Debt to Equity Ratio, and Price Earning Ratio have joint effects on the stock price of the food and beverage companies. The coefficient determination of this model was found to be about only 21,9%. This suggests that the three independent variables underestimated have a lack of explanatory power of the stock price of food and beverage companies. Hence, further studies to seek other independent variables in the model are suggested to improve the model underestimated.
Analisis Pengaruh Biaya Preliminaries Terhadap Produktivitas Karyawan pada Proyek-Proyek PT. X
Authors: Devina Clara , Herjanto Eddy
Published: May 2020

PT.X is a contractor that has productivity problem that is affected by the cost of preliminaries cost. Preliminaries cost for PT. X is divided into 5 parts consisting of employee costs, general costs, financial costs, preparation costs and equipment costs. Employee costs have the largest portion of the cost of other preliminaries. In this study, the authors intend to review the effect of cost preliminaries on productivity in PT. X. The results of the research show that employee costs are 43% of the total cost of preliminaries and 5% of the VOW value. Further research shows that the building type of the project, the number of employees, and employee salaries have a positive effect on the productivity value of a project. The strategy that companies can implement to increase productivity is to set project productivity targets of 480 million / person / month and 45 rp / rp.
Percepção sobre saúde bucal e a importância do acompanhamento odontológico durante o período gestacional e puerperal
Authors: Soares Ana Larissa Fernandes de Holanda , Cabral Chauí de Lima , Beserra Sanny da Silva Fonseca , Santiago Renata Taise da Costa Feliciano , Borges Fernando Jales , Medeiros Isaías Lopes de , Leite Layza Tércia Marcelino , Silva Juliana Fernandes da , Araújo Hiago Bruno Pereira de , Amorim Jéssica Pessoa , Rodrigues Airton Coimbra Monteiro de Medeiros
Published: May 2020

Objetivo: Discutir sobre o acompanhamento odontológico e a importância da saúde bucal no período gestacional e puerperal. Métodos: Estudo transversal, descritivo, exploratório e quantitativo realizado em uma maternidade na capital do Rio Grande do Norte. Participaram desta pesquisa 72 mulheres - gestantes e puérperas - que estavam internadas na maternidade durante o período da coleta de dados (abril de 2018/maio de 2018). Resultados: Os resultados apontaram que 75% das entrevistadas não receberam informações de saúde bucal na gravidez e, das que receberam, a principal fonte de informações foi o profissional dentista; 61% das gestantes e puérperas informaram acreditar que a gravidez em si pode ocasionar algum problema na cavidade oral. Dentre os problemas bucais mais apontados estão o sangramento gengival, a sensibilidade dentária e dente enfraquecido. Conclusão: O pensamento de que grávida não pode ter assistência odontológica foi o principal mito identificado. Assim, acentuamos a importância de uma maior inserção da equipe de saúde bucal nos trabalhos multi e interprofissionais, com atuação de promoção e proteção da saúde e prevenção de doenças para desmistificar o acompanhamento odontológico na gestação e melhorar a percepção deste público para com sua saúde bucal.
Tıp Fakültesi 5 ve 6. sınıf öğrencilerinin hekime yönelik şiddet deneyimlerinin, eğitim, hasta beklentisi ve başa çıkma stilleri ile ilişkisi
Authors: İNANICI Sinem , YARDIMCI Galip , BİNATAMİR Yeliz R. , YÜKSEL Rozerin Göze
Published: May 2020

Giriş ve Amaç: Hekime yönelik şiddet olayları giderek artmaktadır ve bunların olumsuz sonuçlarından sadece hekimler değil henüz eğitim aşamasında olan hekim adayları da etkilenmektedir. Klinik ortamda karşılaştıkları şiddet olaylarıyla başa çıkma konusunda eğitilmemiş adayların daha eğitim döneminde bir takım sıkıntılar yaşama ihtimali vardır. Bu çalışmada hedeflenen klinik dönem öğrencilerinde hekime yönelik şiddet, hasta beklentilerini karşılama ve stresle başa çıkma becerileri arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntem: Katılımcılar İstanbul’daki bir Tıp Fakültesi’nde okuyan 5. ve 6. sınıf öğrencileridir. Araştırma anketinde demografik bilgiler, şiddet deneyimleri ve şiddetin nedeniyle ilgili atıfları ortaya koyan sorular, Hasta Beklentilerini Yönetme Becerisi Ölçeği ve Başa Çıkma Stilleri Ölçeği Kısa Formu bulunmaktadır. Analizler SPSS 15.0 ile yapılmış, ortalama, frekans dağılımları hesaplanmış, Spearman korelasyonu, Ki kare testi, Mann-Whitney U Test’i uygulanmıştır.Bulgular: Kişilerin kendisinin şiddete maruz kalıp kalmaması/şahit olup olmaması cinsiyete göre değişiklik göstermemiştir. Öğrencilerin şahit oldukları şiddet olayına müdahale etmeme oranı %78.7’dir. Katılımcıların %56.8’i ileride şiddete maruz kalma ihtimaliyle ilgili endişe seviyesini epey/son derece olarak bildirmiştir. Yüz yetmiş dört kişi (%82.9) şiddet olaylarının hekimlik eğitimini olumsuz yönde etkilediğini bildirmektedir. Öğrencilerin günlük hayatta sağlık ve hekimlikle ilgili konuşmalarının yaklaşık %16.50’si şiddetle ilişkilidir. Kadınların erkeklere göre, ileride şiddete maruz kalmayla ilgili endişeleri daha yüksektir. Şiddetin nedeniyle ilgili atıflar genelde dışsal niteliktedir. Madde kullanma şeklindeki başa çıkma stratejisi erkeklerde daha yüksek orandadır.Sonuç: Tıp fakültesi öğrencileri, daha eğitim döneminde şiddete maruz kalmakta, şiddet olaylarına müdahale edememekte ve dolayısıyla bu olayların yarattığı endişeyi hem öğrenme süreçlerinde hem de geleceğe projekte ederek deneyimlemektedir. Şiddeti sezmek ve yatıştırmak, daha lisans eğitimi döneminde kazanılması gereken klinik becerilerdendir.
Öğretim Tasarımı, Modelleri ve Program Geliştirmeyle İlişkisi
Authors: KIYAK Yavuz Selim , BUDAKOĞLU İrem , COŞKUN Özlem
Published: May 2020

Giriş: Öğretim tasarımı ve program geliştirme kavramları iki ayrı sürece işaret etse de birbirleriyle ilişkilidir. Bu durum, birbirleriyle benzerlik ve farklılıklar oluşturmakta ve dolayısıyla söz konusu iki kavramın sınırları hakkında karışıklığa yol açmaktadır. Amaç: Bu çalışmanın amacı, öğretim tasarımı ve program geliştirme arasındaki ilişkiyi inceleyip bazı öğretim tasarım modellerini ifade ederek alan yazındaki açığın kapanmasına katkıda bulunmaktır. Gereç ve yöntem: Bunun için önce öğretim ve program kavramları açıklanmıştır. Daha sonra öğretim tasarımı süreci incelenmiş ve bunlarla ilgili örnekler tıp eğitimi alanından verilmiştir. Daha sonra da öğretim tasarımı ve program geliştirme arasındaki ilişki ifade edilmiştir. Makalenin son bölümünde ise sırasıyla “4C/ID” modelinden, ADDIE yaklaşımından, “Dick, Carey ve Carey”, “Keller’ın ARCS Motivasyon”, “ASSURE”, “Kemp, Morrison ve Ross” ve “Gerlach ve Ely” adlı öğretim tasarım modellerinden bahsedilmiştir.Bulgular ve sonuç: Program geliştirme, amaç ve hedeflerin ne olması gerektiğiyle ilgiliyken; öğretim tasarımı, o amaç ve hedeflere nasıl ulaşılacağı ile ilgilidir. Program geliştirme daha geniş, öğretim tasarımı ise dar kapsamlıdır. Genel olarak böyle bir ayrım yapılabilmesine rağmen öğretim tasarımı ile program geliştirme arasındaki sınırın kesin yeri belirli değildir. Çünkü literatürde bu sınırın nerede olduğuna dair çeşitli görüşler mevcuttur. 4C/ID öğretim tasarım modeli, özellikle tıp eğitimi alanında etkin bir şekilde kullanılabilen bir modeldir. ADDIE, bazı yayınlarda öğretim tasarım modeli olarak değerlendirilmiş olsa da bir model değildir, yaklaşımdır. ASSURE öğretim tasarım modelinden, öğretimde teknoloji desteği kullanılmak istendiğinde yararlanılabilir ve bu model öğretim tasarımı için çok sayıda kişi gerektirmez, tek bir eğitici bile kendi başına kullanabilir. Gerlach ve Ely öğretim tasarım modeli de profesyonel öğretim tasarımcılarını gerektirmez. Eğiticilerin içeriğin başta belirlenmesine yönelik eğilimini dikkate alarak modelin başlangıcına içeriğin belirlenmesini koyması, bu modeli farklı kılan bir özelliktir.
Binding of Biologically Relevant Divalent Cations to Aqueous Carboxylates: Molecular Simulations Guided by Raman Spectroscopy
Authors: Mendes de Oliveira Denilson , Zukowski Samual R. , Palivec Vladimir , Hénin Jérôme , Martinez-Seara Hector , Ben-Amotz Dor , Jungwirth Pavel , Duboué-Dijon Elise
Published: May 2020

In spite of the biological importance of the binding of Zn2+, Ca2+, and Mg2+ to carboxylate anions, previous experimental and computational studies have reached conflicting conclusions regarding the corresponding binding affinities. Here, we report the first use of Raman multivariate curve resolution (Raman-MCR) vibrational spectroscopy to obtain self-consistent free and bound metal acetate spectra and one-to-one binding constants, without the need to invoke any a priori assumptions regarding the shapes of the corresponding vibrational bands. The experimental results, combined with classical molecular dynamics simulations with a force field effectively accounting for electronic polarization via charge scaling and ab initio simulations, indicate that the measured binding constants pertain to direct (as opposed to water separated) ion pairing. The resulting binding constants do not scale with cation size, as the binding constant to Zn2+ is significantly larger than that to either Mg2+ or Ca2+, although Zn2+ and Mg2+ have similar radii that are about 25% smaller than Ca2+. Remaining uncertainties in the metal acetate binding free energies are linked to fundamental ambiguities associated with identifying the range of structures pertaining non-covalently bound species.
ACE-2-derived Biomimetic Peptides for the Inhibition of Spike Protein of SARS-CoV-2
Authors: Panda Saroj Kumar , Gupta Parth Sarthi Sen , Biswal Satyaranjan , Ray Abhik Kumar , Rana Malay Kumar
Published: May 2020

SARS-CoV-2, a novel coronavirus causing overwhelming death and infection worldwide, has emerged as a pandemic. Compared to its predecessor SARS-CoV, SARS-CoV-2 is more infective for being highly contagious and exhibiting tighter binding with host angiotensin-converting enzyme 2 (hACE-2). The entry of the virus into host cells is mediated by the interaction of its spike protein with hACE-2. Thus, a peptide that has a resemblance to hACE-2 but can overpower the spike protein-hACE-2 interaction will be a potential therapeutic to contain this virus. The non-interacting residues in the receptor-binding domain of hACE-2 have been mutated to generate a library of 136 new peptides. Out of this library, docking and virtual screening discover seven peptides that can exert a stronger interaction with the spike protein than hACE-2. A peptide derived from simultaneous mutation of all the non-interacting residues of hACE-2 yields two-fold stronger interaction than hACE-2 and thus turns out here to be the best peptide-inhibitor of the novel coronavirus. The binding of the spike protein and the best peptide-inhibitor with hACE-2 is explored further by molecular dynamics, free energy, and principal component analysis to demonstrate its efficacy. Further, the inhibition assay study with the best peptide inhibitor is in progress.
In Silico Pharmacophore Study and Structural Optimization of Nafamostat Yield Potentially Novel Transmembrane Protease Serine 2 (TMPRSS2) Inhibitors Which Block the Entry of SARS-CoV-2 Virus into Human Cells
Authors: Nguyen Bach
Published: May 2020

The past 6 months since December 2019 were marked by the COVID-19 pandemic caused from the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the urgent state worldwide, many efforts have been directed on repurposing approved drugs to facilitate the discovery of effective therapies. In this work, I employ molecular docking (in silico) as an approach to study the intermolecular interactions between Nafamostat mesylate – an approved anticoagulant drug, and transmembrane serine protease 2 (TMPRSS2) which is crucial for coronaviruses to enter host cells. Furthermore, structural optimization of Nafamostat is performed using pharmacophoric approach which indicates some small molecules as potentially effective TMPRSS2 inhibitors and pharmaceutical candidates for COVID-19 pandemic.
Scalable Synthesis of Crystalline One-Dimensional Carbon Nanothreads Through Modest-Pressure Polymerization of Furan
Authors: Huss Steven , Wu Sikai , Chen Bo , Wang Tao , Gerthoffer Margaret , Hoffmann Roald , Crespi Vincent , Badding John , Elacqua Elizabeth
Published: May 2020

Carbon nanothreads, which are unique one-dimensional sp3-rich polymers, combine high tensile strength with flexibility owing to subnanometer widths and diamond-like cores. These extended carbon solids are constructed through pressure-induced polymerization of sp2 molecules such as benzene. Whereas a few examples of carbon nanothreads have been reported, the need for high onset pressures ( ≥ 17 GPa) to synthesize them precludes scalability and limits scope. Herein, we report the scalable synthesis of carbon nanothreads based on molecular furan, which can be achieved through ambient temperature pressure-induced polymerization with an onset reaction pressure of only 10 GPa due to its lessened aromaticity relative to other molecular precursors. When slowly compressed to 15 GPa and gradually decompressed to 1.5 GPa, a sharp six-fold diffraction pattern is observed in situ, indicating a well‐ordered crystalline material formed from liquid furan. Single-crystal X-ray diffraction of the reaction product exhibits three distinct d-spacings from 4.75 to 4.9 Å, whose size, angular spacing, and degree of anisotropy are consistent with our atomistic simulations for crystals of furan nanothreads. Further evidence for polymerization was obtained by powder XRD and Raman/IR spectroscopy. Comparison of the IR spectra with computed vibrational modes provides identification of spectral features characteristic of specific nanothreads, namely syn, anti, and syn/anti configurations. Furan therefore presents a strategic entry toward scalable carbon nanothreads.
Synthesis of 1,2,3-Triazole-Containing Furanosyl Nucleoside Analogs and Their Phosphate, Phosphoramidate or Phoshonate Derivatives as Potential Sugar Diphosphate or Nucleotide Mimetics
Authors: Fortuna Andreia , Costa Paulo J. , Piedade Fátima , Oliveira M. Conceição , Xavier Nuno Manuel
Published: May 2020

The synthesis of a variety of novel, rather stable and potentially bioactive nucleoside analogs and nucleotide mimetics based on xylofuranose scaffolds and comprising a 1,2,3-triazole moiety as a surrogate for a nucleobase or a phosphate group is reported. Isonucleosides embodying a 3-O-(benzyltriazolyl)methyl moiety at C-3 were accessed by using the Cu(I)-catalyzed “click” 1,3-dipolar cycloaddition between 3-O-propargyl-1,2-O-isopropylidene-α-D-xylofuranose and benzyl azide as the key step. Related isonucleotides comprising a phosphate or a phosphoramidate moiety at C-5 were obtained via 5-O-phosphorylation of acetonide-protected 3-O-propargyl xylofuranose followed by “click” cycloaddition or by Staudinger reaction of a 5ʹ-azido N-benzyltriazole isonucleoside with triethyl phosphite, respectively. Hydroxy, amino- or bromomethyl triazole 5ʹ-isonucleosides were synthesized through thermal cycloaddition between 5-azido 3-O-benzyl/dodecyl-1,2-O-isopropylidene-α-D-xylofuranoses and propargyl alcohol, propargylamine or propargyl bromide, respectively. The regiochemical outcome of the cycloaddition reactions was influenced by nature of the alkyne hetero substituent (alkyne CH2X substituent). The 5´-isonucleosides were converted into their [(xylofuranos-5-yl)triazolyl]methyl phosphate, phosphoramidate and phosphonate derivatives as prospective sugar diphosphate mimetics by an appropriate method involving treatment with diethyl phosphorochloridate or a Michaelis-Arbuzov reaction. 4-Phosphonomethyl-1-xylofuranos-5ʹ-yl triazoles were converted into 1,2-O-acetyl glycosyl donors and subsequently subjected to nucleosidation with uracil leading to the corresponding uracil nucleoside 5ʹ-(triazolyl)methyl phosphonates, whose structure potentially mimics that of a nucleoside diphosphate.
Modern molecular and biological aspects of endometriosis-associated infertility
Authors: Safronova Anastasiia S , Vysokikh Mikhail Yu , Chuprynin Vladimir D , Buralkina Natalia A
Published: May 2020

There is currently no consensus on the etiopathogenetic nature of endometriosis. The causes of aggressive, progressive, infiltrative growth of endometrioid tissue also remain unclear. An important problem remains the high recurrence rate of endometriosis, despite the availability of modern drug and surgical methods of treatment. The study of the central signaling pathways and the search for new key molecules is of paramount importance for a better understanding of the pathogenesis of the disease, and is also an important step in the development of new strategies for the diagnosis, prevention and treatment of endometriosis.
Chronic endometritis: the state of the problem examination
Authors: Dobrokhotova Iuliia E , Borovkova Ekaterina I , Skal'naia Viktoriia S , Borovkov Ivan M
Published: May 2020

Chronic endometritis is a clinical morphological syndrome that develops as a result of a self-sustaining pathological process, which is based on a violation of the production of pro-inflammatory cytokines initiated by an infectious factor. The article presents the clinical and etiological classification of endometritis, the pathogenesis of development in terms of involvement of immunocompetent cells, standards for diagnosis and therapy.
Features of ambulatory and stationary treatment of patients with endometriosis
Authors: Oboskalova Tat’iana A. , Gluhov Evgenii Yu. , Astryuhina Irina I.
Published: May 2020

Background. Most common clinical manifestations of endometriosis (N80) include pelvic pain and infertility, while adenomyosis is associated with abnormal uterine bleeding. At present, approach to the treatment of endometriosis has been revised towards shifting surgery to the second-line therapy; medications are considered as the first-line therapy: gonadotropin releasing hormone agonists, progestogens, aromatase inhibitors.

Aim. Comparison of clinical and anamnestic characteristics and therapeutic procedures in women who were treated on an outpatient basis and those who were hospitalized and underwent surgical intervention.

Materials and methods. Clinical-anamnestic and morphological characteristics were studied in two groups of women: 1st group (n=27) received drug therapy, 2nd group (n=28) underwent surgical intervention.

Results and discussion. In the 1st group, 25.9% of patients received microdosed combined oral contraceptives which contain dienogest as a progestogen component, 44.4% of patients received monotherapy with dienogest, and 22.2% of patients received dydrogesterone in a prolonged mode. In the 2nd group, 39 foci of endometriosis, isolated and in a combination of various loci, were revealed during surgery, of which 30.8% were ovarian cysts, 10.2% were foci on the sacro-uterine ligaments, 23.1% were on the pelvis peritoneum. Surgical approach was determined by the urgency of intervention, an expect localization of endometriosis foci, a comorbidity of endometriosis with another pathology of the internal genitalia, 82.1% of surgery were performed by laparoscopic approach.

Conclusions. The choice of treatment method depends on the severity of symptoms, the severity of endometriosis, the woman age and her reproductive intentions. When choosing a surgical treatment, one should be guided not only by the need for the most radical removal of endometriosis foci, but also should consider a surgical approach to minimize discomfort and provide a good quality of life after surgery. A three-stage model for the management of patients with endometriosis is proposed, which includes an assessment of treatment effectiveness and the need to develop a rehabilitation program.
DESCRIBING KITAB PERUKUNAN BESAR MELAYU BY ABDUL RASYID BANJAR FROM THE LETTER OF ALPHABET CONCEPT TO SYNTHESIS CONSTRUCTION
Authors: MZ Zulfiana Amaliana
Published: May 2020

As the spread of Islam in the archipelago, a manuscript found in 19th century AD entitled Perukunan Besar Melayu by Abdul Rasyid Banjar. It was about Fiqh which described using Bahasa and written in Arab-Melayu. So, it used as an object of research that categorized as a qualitative research with a philological descriptive approach. This study aims to describe 1) transliterated of the manuscript to obtain complete and clear editing, 2) compliances of spelled and punctuated, and 3) distribution of syntax. To achieve the research objectives, data analysis carried out using the philological work procedure techniques and comparative analysis. So, the result of this research is 1) transliterated  of Arab-Melayu alphabet into Latin alphabet, 2) reconstruction of spelled and punctuated, and 3) syntactic reconstruction
KETIDAKEFEKTIFAN KALIMAT PADA SKRIPSI MAHASISWA PROGRAM STUDI PENDIDIKAN BAHASA DAN SASTRA INDONESIA STKIP PGRI SUMATERA BARAT
Authors: Yulianti Upit , Fitri Rahayu , Putri Febrina Riska , Silvia Ayu Zalina
Published: May 2020

Penelitian ini dilatarbelakangi oleh kesalahan yang sering terjadi dalam hal penulisan kalimat pada skripsi mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia di STKIP PGRI Sumatera Barat. Tujuan penelitian adalah untuk mendeskripsikan ketidakefektifan kalimat dalam skripsi mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia di STKIP PGRI Sumatera Barat. Data penelitian adalah kalimat tidak efektif yang ditemukan dalam skripsi mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia STKIP PGRI Sumatera Barat. Teknik pengumpulan data adalah metode simak. Teknik analisis data adalah membaca dan menandai, menginventarisasi, mengklasifikasikan, menganalisis, melakukan pembahasaan dan penyimpulan hasil penelitian. Hasil dari penelitian ini adalah terdapat ketidakefektifan kalimat dalam skripsi mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia di STKIP PGRI Sumatera Barat dalam hal kesepadanan, keparalelan, ketegasan, kehematan, kecermatan, kepaduan, dan kelogisan.
KONTRUKSI VERBA SERIAL BAHASA DAYAK KENYAH LEPO’ TAU
Authors: Dicky Romadhan Ahmad
Published: May 2020

This study discusses the construction of serial verbs in the Lepo Dayak Kenyah language 'Tau. This research is a qualitative descriptive type. The data in this study were taken from native Lepo Dayak Kenyah speakers. The collection technique uses the listening technique and notes accompanied by elicitation techniques. The results of this study state that the construction of serial verbs in the Lepo 'Tau Dayak Kenyah language has the same characteristics as the extensive serial verb construction typology. In this study also found several semantic types in the construction of serial verbs in the Lepo 'Tau Dayak Kenya language, namely type of movement, directional type, type of type, cause-effect type, type of modality and type of aspect.
Differentiated perceived match load and its variability according to playing position in professional soccer players during an entire season
Authors: Azcárate Unai , Yanci Javier , Los Arcos Asier
Published: May 2020

The
aims were to assess differentiated perceived match exertion and its variability according to playing position
for professional soccer players. Nineteen Spanish players declared their
respiratory and muscular perceived exertions (PEs) after official matches during
an entire season. Players were classified according to their playing position. In order to
assess differentiated perceived match exertion, soccer players were asked to
assess their perceived level of exertion following each official match. Considerable
differences (p<.05; ES=.41-2.49)
were found between some playing positions but not always in both dimensions of PE
(respiratory and muscular). Advanced midfielders (AvMs), wide midfielders
(WMs) and wing backs (WnBs)
reported the highest match respiratory PE and muscular PE scores. Furthermore,
match-to-match differentiated perceived match exertion variability ranged from
12.8 to 27.7% for respiratory perceived exertion and from 11.5 to 25.2% for muscular
perceived exertion according to playing position. Match respiratory-muscular PE differences
varied among the playing positions, showing higher muscular PE than respiratory
PE in central backs (CBs), WMs and central midfielders (CMs) (p<.05; ES=-.35 to .68), but higher respiratory
PE than muscular PE in wing backs (p<.05; ES=-.35). Soccer differentiated perceived
match exertion is different inter and intra some playing positions, showing
large swings for match-to-match variability between playing positions. These
facts confirm that the deconstruction of the overall PE provides a more accurate
evaluation of the subjective match internal load in some playing positions.
Geographic risk of general and abdominal obesity and related determinants in Iranian children and adolescents: CASPIAN-IV Study
Authors: Yazdi Maryam , Kelishadi Roya , Schmid Volker , Motlagh Mohammad Esmaeil , Heshmat Ramin , Mansourian Marjan
Published: May 2020

Background: Obesity, as a risk factor for many noncommunicable diseases, is a common public health problem in developed and developing countries. Among Iranian children and adolescents, the prevalence of being overweight has increased by almost 50% in the past two decades. Aims: To visualize the geographic differences in general and abdominal obesity risks and related determinants among Iranian children and adolescents. Methods: Participants consisted of 14 880 students, aged 7–19 years, living in urban and rural areas of the Islamic Republic of Iran. Spatial patterns of obesity and its association with related risk factors were identified using Bayesian spatial modeling. Results: The highest spatial risks of general obesity (odds ratio 1.21–1.66 for males and 1.81–2.02 for females) and abdominal obesity (odds ratio 1.20–1.82 for males and 1.25–1.78 for females) were observed in the north, northwest and southwest of the country. Risk of obesity was significantly higher in areas with a higher rate of urban residence, active current smokers and prolonged screen time. Conclusion: Identification of high-risk regions for obesity and spatially related risk factors can be used as informative tools for decision-making and planning in health systems at national and subnational levels.
Análisis proximal y perfil de aminoácidos del aislado proteico del chocho andino ecuatoriano (Fabaceae: Lupinus mutabilis)
Authors: Guerra F. Daniela , Pozo P. Pablo
Published: May 2020

El propósito de este estudio fue aislar contenido proteico total de los granos de chocho (Fabaceae: Lupinus mutabilis ). El contenido de macronutrientes ha sido evaluado a través de un análisis proximal: proteína total (67,25 %), carbohidratos (18,67 %), grasa (5,95 %), ceniza (4,12 %) y humedad (4,01 %). El análisis por cromatografía de capa fina ha demostrado que había siete aminoácidos esenciales presentes en el aislado proteico: ácido glutámico, treonina, valina, isoleucina, leucina, metionina y triptófano; además, la presencia de ácido glutámico y de aminoácidos de cadena ramificada.
Determinación de BTEX en aire ambiente del Distrito Metropolitano de Quito mediante cromatografía de gases con detector de ionización de llama
Authors: Altamirano Camila , Meneses Lorena
Published: May 2020

La contaminación ambiental puede ser natural o antropogénica, que causa la presencia de determinadas sustancias que interfieren con la salud y el bienestar de los habitantes. En el caso específico del Distrito Metropolitano de Quito (DMQ), los contaminantes se encuentran principalmente en las gasolinas, por esta razón se determinó benceno, tolueno, etilbenceno, m/p -xileno y o -xileno (BTEX), considerados como contaminantes de origen antropogénico, en el aire ambiente del DMQ, para identificar las fuentes y períodos de contaminación, con el fin de controlarlas y reducir el impacto ambiental. La determinación de BTEX se realizó mediante el muestreo pasivo junto con una extracción por ultrasonido, utilizando hexano como solvente, para su posterior análisis mediante cromatografía de gases con detector de ionización de llama. Las condiciones cromatográficas permitieron la separación, identificación y cuantificación de los compuestos de interés. Se monitoreó BTEX en 43 puntos distribuidos a lo largo y ancho de todo el DMQ con un tiempo de exposición de 30 días. El rango de concentración promedio encontrado durante los meses de octubre 2016 a enero 2017 para benceno fue 0,07 – 13,85 μ g/m 3 ; valor que superó la normativa ambiental anual establecida por la Comisión Europea, con un valor de 5 μ g/m 3 . El aumento de la concentración de BTEX en el año 2017 frente a los años ante- riores, se debe al aumento en la congestión vehicular, así como el uso de com- bustible en las festividades del mes de diciembre 2016 y enero 2017.
Análisis mineralógico y multielemental de la ceniza volcánica, producto de la erupción del Cotopaxi en 2015, por difracción de rayos X (XRD) y espectrometría de masas con plasma acoplado inductivamente (ICP-MS) y sus posibles aplicaciones e impactos
Authors: Sánchez Esteban , Vizcaino Gabriel , Mejía Fátima , Cipriani Ávila Isabel
Published: May 2020

Este estudio tuvo como objetivo principal el análisis mineralógico y multiele- mental de la ceniza volcánica producto de la erupción del volcán Cotopaxi en agosto de 2015; con el fin de determinar posibles aplicaciones e impactos. Las técnicas de difracción de rayos X (XRD) y espectrometría de masas con plasma acoplado inductivamente (ICP-MS) fueron usadas para el análisis de las muestras. El análisis por ICP-MS demostró concentraciones importantes de aluminio, azufre, hierro, calcio, magnesio, titanio, metales alcalinos y alcalinotérreos, elementos característicos de una composición andesítica. Mediante el análisis por XRD se determinó que los minerales mayoritarios presentes en la fase cristalina son plagioclasas, ortoclasas y óxidos de silicio (cristobalina), y entre los minoritarios fueron encontrados: óxidos de hierro (magnetita, hematita y maghemita), yeso, dolomita y mayenita. El estudio bibliográfico de las diferentes aplicaciones tanto de los elementos y minerales encontrados en la ceniza, permite recomendar el uso de este material como agregado en materiales y construcción gracias a su composición mineralógica, y evitar su uso como fertilizante sin un análisis previo del pH del suelo, ya que podría resultar potencialmente tóxico.
Döviz Kurlarının Enflasyon Üzerindeki Etkisi: Türkiye Üzerine Ampirik Bir İnceleme
Authors: DEMİR Emre , YENİPAZARLI Aslı
Published: May 2020

Bu çalışmada, Türkiye’de döviz kurlarında meydana gelen şokların, enflasyon üzerindeki etkisi vector otoregresif (vector autoregressşon: VAR) yöntemi yardımıyla, 2003: M1 – 2018: M6 dönemi aylık veriler kullanılarak test edilmiştir. Elde edilen sonuçlara göre döviz kurlarında meydana gelen azalışlarım enflasyonist etkilere sebep olduğu görülmüştür. Ayrıca analizde 2008 küresel krizin hem enflasyon hem de döviz kuru üzerinde anlamlı etkisi tespit edilmiştir. Çıkarılan sonuçtan anlaşılacağı üzere, siyasi istikrar dönemde uygulanan döviz kurunu azaltıcı politikalar, enflasyonist hareketlere sebep olmaktadır.
Estimation of the Bankruptcy Risk of the Companies in the BIST Construction Index
Authors: KARACA Samuray , KARACA Ahmet
Published: May 2020

In this
study, it is aimed to measure the effects of the recent négative developments
in the Turkish Construction sector on the financial failures of the companies
in Borsa Istanbul Construction Index. This study is particularly important with
regard to determining whether the concordat announcements, which started
especially in the 3rd quarter of 2018, carry a risk for the construction sector
and ascertaining whether there have been any warnings beforehand.The
financial statements of the companies in the construction sector in 2010-2018
period will be analyzed with the Altman Z score model to see if they carry
bankruptcy risk. In addition, by comparing the calculated Z scores with the
stock prices of stock certificates, the extent to which the probabilities of
bankruptcy are priced in the stock market will also be measured.

Predicting bankruptcy risk is vital for both firms and
stakeholders. The findings will contribute significantly to strategy
determination for firms and investors in this sector. On the other hand, the
results will also guide investors' stock preferences.