bluuebunny/crossref_metadata_2025 huggingface dataset:
Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study
Authors: Gaab Christine , Adolph Jonas E. , Tippelt Stephan , Mikasch Ruth , Obrecht Denise , Mynarek Martin , Rutkowski Stefan , Pfister Stefan M. , Milde Till , Witt Olaf , Bison Brigitte , Warmuth-Metz Monika , Kortmann Rolf-Dieter , Dietzsch Stefan , Pietsch Torsten , Timmermann Beate , Sträter Ronald , Bode Udo , Faldum Andreas , Kwiecien Robert , Fleischhack Gudrun
Published: January 2022

Recurrent medulloblastomas are associated with survival rates <10%. Adequate multimodal therapy is being discussed as having a major impact on survival. In this study, 93 patients with recurrent medulloblastoma treated in the German P-HIT-REZ 2005 Study were analyzed for survival (PFS, OS) dependent on patient, disease, and treatment characteristics. The median age at the first recurrence was 10.1 years (IQR: 6.9–16.1). Median PFS and OS, at first recurrence, were 7.9 months (CI: 5.7–10.0) and 18.5 months (CI: 13.6–23.5), respectively. Early relapses/progressions (<18 months, n = 30/93) found mainly in molecular subgroup 3 were associated with markedly worse median PFS (HR: 2.34) and OS (HR: 3.26) in regression analyses. A significant survival advantage was found for the use of volume-reducing surgery as well as radiotherapy. Intravenous chemotherapy with carboplatin and etoposide (ivCHT, n = 28/93) showed improved PFS and OS data and the best objective response rate (ORR) was 66.7% compared to oral temozolomide (oCHT, n = 47/93) which was 34.8%. Intraventricular (n = 43) as well as high-dose chemotherapy (n = 17) at first relapse was not related to a significant survival benefit. Although the results are limited due to a non-randomized study design, they may serve as a basis for future treatment decisions in order to improve the patients’ survival.
Epigenetic Therapies and Biomarkers in Breast Cancer
Authors: Brown Lauren Julia , Achinger-Kawecka Joanna , Portman Neil , Clark Susan , Stirzaker Clare , Lim Elgene
Published: January 2022

Epigenetic therapies remain a promising, but still not widely used, approach in the management of patients with cancer. To date, the efficacy and use of epigenetic therapies has been demonstrated primarily in the management of haematological malignancies, with limited supportive data in solid malignancies. The most studied epigenetic therapies in breast cancer are those that target DNA methylation and histone modification; however, none have been approved for routine clinical use. The majority of pre-clinical and clinical studies have focused on triple negative breast cancer (TNBC) and hormone-receptor positive breast cancer. Even though the use of epigenetic therapies alone in the treatment of breast cancer has not shown significant clinical benefit, these therapies show most promise in use in combinations with other treatments. With improving technologies available to study the epigenetic landscape in cancer, novel epigenetic alterations are increasingly being identified as potential biomarkers of response to conventional and epigenetic therapies. In this review, we describe epigenetic targets and potential epigenetic biomarkers in breast cancer, with a focus on clinical trials of epigenetic therapies. We describe alterations to the epigenetic landscape in breast cancer and in treatment resistance, highlighting mechanisms and potential targets for epigenetic therapies. We provide an updated review on epigenetic therapies in the pre-clinical and clinical setting in breast cancer, with a focus on potential real-world applications. Finally, we report on the potential value of epigenetic biomarkers in diagnosis, prognosis and prediction of response to therapy, to guide and inform the clinical management of breast cancer patients.
Catalytic Upgrading of Clean Biogas to Synthesis Gas
Authors: Schiaroli Nicola , Battisti Martina , Benito Patricia , Fornasari Giuseppe , Di Gisi Amalio Giovanni , Lucarelli Carlo , Vaccari Angelo
Published: January 2022

Clean biogas, produced by anaerobic digestion of biomasses or organic wastes, is one of the most promising substitutes for natural gas. After its purification, it can be valorized through different reforming processes that convert CH4 and CO2 into synthesis gas (a mixture of CO and H2). However, these processes have many issues related to the harsh conditions of reaction used, the high carbon formation rate and the remarkable endothermicity of the reforming reactions. In this context, the use of the appropriate catalyst is of paramount importance to avoid deactivation, to deal with heat issues and mild reaction conditions and to attain an exploitable syngas composition. The development of a catalyst with high activity and stability can be achieved using different active phases, catalytic supports, promoters, preparation methods and catalyst configurations. In this paper, a review of the recent findings in biogas reforming is presented. The different elements that compose the catalytic system are systematically reviewed with particular attention on the new findings that allow to obtain catalysts with high activity, stability, and resistance towards carbon formation.
Prevalence of Overweight and Obesity and Associated Diet-Related Behaviours and Habits in a Representative Sample of Adolescents in Greece
Authors: Makri Rafaela , Katsoulis Michail , Fotiou Anastasios , Kanavou Eleftheria , Stavrou Myrto , Richardson Clive , Kanellopoulou Afroditi , Orfanos Philippos , Benetou Vassiliki , Kokkevi Anna
Published: January 2022

Excessive body weight during adolescence represents a significant public health problem worldwide. Identifying factors associated with its development is crucial. We estimated the prevalence of overweight and obesity in a representative sample of 11, 13 and, 15-year-olds living in Greece and explored the association with diet-related behaviours and habits. Self-reported data on weight, height, diet-related behaviours and habits were used from 3816 students (1898 boys, 1918 girls) participants in the Greek arm of the international Health Behaviour in School-Aged Children (HBSC) study during 2018. Overweight and obesity were defined using the 2007 WHO growth charts classification. Prevalence of overweight was 19.4% in the total sample, 24.1% for boys and 14.7% for girls, and prevalence of obesity was 5.3% in the total sample, 7.3% for boys and 3.4% for girls, respectively. In the total sample, overweight (including obesity) was positively associated with male gender, low family affluence, skipping breakfast, and being on a diet, and inversely associated with age and being physically active. Eating rarely with the family was positively associated with overweight only among boys and eating snacks/meals in front of screens only among girls. No association was noted for eating in fast-food restaurants, consuming vegetables, fruits, sweets, and sugar-sweetened beverages.
Clinical Clues of Pre-Symptomatic Pancreatic Ductal Adenocarcinoma Prior to Its Diagnosis: A Retrospective Review of CT Scans and Laboratory Tests
Authors: Chung Hwe Hoon , Lim Kyung Sook , Park Joo Kyung
Published: January 2022

Most pancreatic ductal adenocarcinoma cases are unresectable at the time of diagnosis. Only early diagnosis and curative resection can help prolong survival. We tried to find out useful clinical clues of pre-symptomatic area prior to pancreatic cancer diagnosis compared to normal controls. Of 4799 patients diagnosed with pancreatic cancer between 1995 and 2014 at the Samsung Medical Center, 51 were selected for study. They had no symptoms at diagnosis and underwent computed tomography 6 to 36 months prior to diagnosis for reasons other than cancer diagnosis. We selected 288 control subjects who underwent computed tomography during the same period. Data were retrospectively reviewed included various variables. Fasting blood sugar (171.8 ± 97.5 vs. 115.8 ± 34.8 units, p < 0.05), new onset diabetes mellitus within 3 years (12/51 (23.5%) vs. 17/181 (9.8%), p < 0.05), carbohydrate antigen 19-9 level (609.5 ± 2342.5 vs. 17.0 ± 26.2, p = 0.08), main pancreatic duct dilatation (26/51 (51.0%) vs. 57/181 (31.5%), p < 0.05) in computed tomography scan were higher in pancreatic cancer group than in normal group, respectively. In multi-variate analysis, carbohydrate antigen 19-9, new onset diabetes mellitus (<3 years), and segmental main pancreatic duct dilatation were independent risk factors for pancreatic cancer. Our study concluded that independent risk factors for pancreatic cancer were elevated carbohydrate antigen 19-9, new onset diabetes mellitus (<3 years), and local main pancreatic ductal dilatation on computed tomography scan.
Experimental Study of Black Cotton Soil Stabilization with Natural Lime and Pozzolans in Pavement Subgrade Construction
Authors: Yin Zihong , Lekalpure Raymond Leiren , Ndiema Kevin Maraka
Published: January 2022

This study explores the engineering characteristics of Black cotton soil (BCS) stabilized with natural lime, volcanic ash (VA), and their mixtures. Based on the available literature, the stabilization of VA-BCS is limited. Laboratory tests conducted on stabilized BCS include the Atterbeg limits, the proctor test, the swell percent test, and the California bearing ratio (CBR). The results showed that adding VA and lime greatly improves the engineering characteristics of BCS. BCS stabilized with a mixture of VA and lime showed superior results. Adding 3% lime with 20% VA increased natural CBR values 10.76 times, reduced plasticity by 29%, and reduced swell percent by 88%. Stabilized BCS with 3% lime + 20% VA meets the minimum swell, plasticity, and strength requirements; thus, it can be used as an alternative to cutting and filling.
Isothermal Oxidation TGO Growth Behaviors of Laser-Remolten LZO/YSZ Thermal Barrier Coatings
Authors: Li Wensheng , Li Ziyu , An Guosheng , Cheng Bo , Song Qiang , Sun Jinquan , Vaganov Victor , Wang Canming , Goransky Georg
Published: January 2022

Laser scanning modification was applied to secondarily melt the top ceramic coating surface of lanthanum zirconate/yttria-stabilized zirconia double ceramic thermal barrier coatings (LZO/YSZ TBCs) to reduce the gas oxygen diffusion and improve the TBCs service life. Isothermal oxidations with different times were carried out on the as-sprayed (AS) TBCs and laser-remolten (LR) TBCs at 1100 °C to investigate thermally growth oxide (TGO)growth mechanisms and isothermal oxidation behaviors. The results showed that the laser-remolten top-ceramic-coating dense layer with a columnar crystal structure of LR TBCs presented a 96.3% and 59.1% lower surface roughness and porosity, respectively, than those of the top ceramic coating of AS TBCs, and the TGO growth rate of LR TBCs decreased by 46.2% compared to that of AS TBCs. The mixed-oxides appearance time of LR TBCs (50 h) was later than that of AS TBCs (25 h). After 100 h of isothermal oxidation, the total TGO thickness of LR TBCs was only 77.2% of that of AS TBCs, and the effects of the laser-remolten TBCs on gas oxygen diffusion inhibition and high-temperature oxidation resistance were promising in LZO/YSZ TBCs.
Synergistic Effect of Hexagonal Boron Nitride-Coated Separators and Multi-Walled Carbon Nanotube Anodes for Thermally Stable Lithium-Ion Batteries
Authors: Ahmed Faheem , Kumar Shalendra , Shaalan Nagih Mohammed , Saber Osama , Rehman Sarish , Aljaafari Abdullah , Abuhimd Hatem , Alshahrani Mohammad
Published: January 2022

In this work, we report the development of separators coated with hexagonal boron nitride (hBN) to improve the thermal stability of Li-ion batteries (LIBs). Aiming to achieve a synergistic effect of separators and anodes on thermal stability and electrochemical performance, multiwalled carbon nanotubes (MWCNTs) were prepared via plasma-enhanced chemical vapor deposition (PECVD) method and used as potential anode materials for LIBs. The grown MWCNTs were well characterized by using various techniques which confirmed the formation of MWCNTs. The prepared MWCNTs showed a crystalline structure and smooth surface with a diameter of ~9–12 nm and a length of ~10 μm, respectively. Raman spectra showed the characteristic peaks of MWCNTs and BN, and the sharpness of the peaks showed the highly crystalline nature of the grown MWCNTs. The electrochemical studies were performed on the fabricated coin cell with a MWCNT anode using a pristine and BN-coated separators. The results show that the cell with the BN-coated separator in a conventional organic carbonate-based electrolyte and MWCNTs as the anode resulted in a discharge capacity (at 65 °C) of ~567 mAhg−1 at a current density of 100 mAg−1 for the first cycle, and delivered a capacity of ~471 mAhg−1 for 200 cycles. The columbic efficiency was found to be higher (~84%), which showed excellent reversible charge–discharge behavior as compared with the pristine separator (69%) after 200 cycles. The improved thermal performance of the LIBs with the BN-coated separator and MWCNT anode might be due to the greater homogeneous thermal distribution resulting from the BN coating, and the additional electron pathway provided by the MWCNTs. Thus, the fabricated cell showed promising results in achieving the stable operation of the LIBs even at higher temperatures, which will open a pathway to solve the practical concerns over the use of LIBs at higher temperatures without compromising the performance.
Precipitant-Free Crystallization of Lysozyme and Glucose Isomerase by Drying
Authors: Suzuki Yoshihisa , Fujiwara Shiori , Ueta Shoko , Sakai Takashi
Published: January 2022

Protein crystallization is usually conducted by using precipitants, although the “salting-out” phenomenon is still unclear and complex. Moreover, the addition of precipitants sometimes results in irreversible disordered precipitation of protein molecules. Although precipitant-free lysozyme crystals obtained by centrifugal concentration showed significant changes in three-dimensional structure compared to the structure of salted-out crystals, it was rather difficult to mount crystals from a viscous dense liquid phase after centrifugal concentration, and the quality of the crystals often deteriorated during the mounting process. Here we present novel precipitant-free crystallization methods, which were effective for lysozyme and glucose isomerase. Tetragonal lysozyme crystals were successfully crystallized in a glass capillary simply by drying highly concentrated lysozyme solution in the presence of 0.01 M hydrochloric acid without using any precipitants. Glucose isomerase dissolved in ultra-pure water was also successfully crystallized in hanging drops by drying highly concentrated solution under low-humidity conditions. Oscillation images of the obtained crystals were safely collected without handling; they clearly indicated the crystals had a tetragonal form for lysozyme and an orthorhombic form for glucose isomerase, and their lattice parameters are similar to those of previously reported crystals obtained by salting-out methods.
Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
Authors: Carreras-Dieguez Núria , Glickman Ariel , Munmany Meritxell , Casanovas Georgina , Agustí Núria , Díaz-Feijoo Berta , Saco Adela , Sánchez Beatriz , Gaba Lydia , Angeles Martina Aida , Pahisa Jaume , Fernández-Galán Esther , Torné Aureli , Fusté Pere
Published: January 2022

(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women with a diagnosis of adnexal mass. We obtained the AUC, sensitivity, specificity and predictive values were of HE4, CA125, ROMA and CPH-I for the diagnosis of EOC and MCO. Subgroup analysis for women harboring adnexal masses with inconclusive diagnosis of malignancy by ultrasound features and Stage I EOC was performed. (3) RESULTS: 1071 patients were included, 852 (79.6%) presented benign/borderline tumors and 219 (20.4%) presented EOC/MCO. AUC for HE4 was higher than for CA125 (0.91 vs. 0.87). No differences were seen between AUC of ROMA and CPH-I, but they were both higher than HE4 AUC. None of the tumor markers alone achieved a sensitivity of 90%; HE4 was highly specific (93.5%). ROMA showed a sensitivity and specificity of 91.1% and 84.6% respectively, while CPH-I showed a sensitivity of 91.1% with 79.2% specificity. For patients with inconclusive diagnosis of malignancy by ultrasound features and with Stage I EOC, ROMA showed the best diagnostic performance (4) CONCLUSIONS: ROMA and CPH-I perform better than tumor markers alone to identify patients harboring EOC or MCO. They can be helpful to assess the risk of malignancy of adnexal masses, especially in cases where ultrasonographic diagnosis is challenging (stage I EOC, inconclusive diagnosis of malignancy by ultrasound features).
Disrupting the Disruption: A Digital Learning HeXie Ecology Model
Authors: Li Na , Huijser Henk , Xi Youmin , Limniou Maria , Zhang Xiaojun , Kek Megan Yih Chyn A.
Published: January 2022

Broad societal disruptions (i.e., the industrial revolution, digitalisation, and globalisation) have created a need for an increasingly adaptive higher education system in recent decades. However, the response to these disruptions by universities has generally been slow. Most recently, online learning environments have had to be leveraged by universities to overcome the difficulties in teaching and learning due to COVID-19 restrictions. Thus, universities have had to explore and adopt all potential digital learning opportunities that are able to keep students and teachers engaged in a short period. This paper proposes a digital learning HeXie ecology model, which conceptualises elements and relationships pertaining to the societal need for a more agile and digitally resilient higher education system that is better placed to confront disruptive events (such as pandemics) and that is able to produce graduates who are well-equipped to deal with disruption and uncertainty more broadly. Specifically, we propose a digital learning ecology that emphasises the role of self-directed learning and its dynamic interaction between formal, informal, and lifelong learning across a five-level ecosystem: the microsystem, mesosystem, exosystem, macrosystem, and chronosystem. This study contributes to the theoretical literature related to flexible learning ecologies by adopting and incorporating the Chinese HeXie concept into such ecologies.
A Systematic Review on Oral Interactions in Robot-Assisted Language Learning
Authors: Lin Vivien , Yeh Hui-Chin , Chen Nian-Shing
Published: January 2022

Although educational robots are known for their capability to support language learning, how actual interaction processes lead to positive learning outcomes has not been sufficiently examined. To explore the instructional design and the interaction effects of robot-assisted language learning (RALL) on learner performance, this study systematically reviewed twenty-two empirical studies published between 2010 and 2020. Through an inclusion/exclusion procedure, general research characteristics such as the context, target language, and research design were identified. Further analysis on oral interaction design, including language teaching methods, interactive learning tasks, interaction processes, interactive agents, and interaction effects showed that the communicative or storytelling approach served as the dominant methods complemented by total physical response and audiolingual methods in RALL oral interactions. The review provides insights on how educational robots can facilitate oral interactions in language classrooms, as well as how such learning tasks can be designed to effectively utilize robotic affordances to fulfill functions that used to be provided by human teachers alone. Future research directions point to a focus on meaning-based communication and intelligibility in oral production among language learners in RALL.
Package-Scale Galvanic Isolators Based on Radio Frequency Coupling: Micro–Antenna Design
Authors: Spataro Simone , Spina Nunzio , Ragonese Egidio
Published: January 2022

This paper presents the design of on-chip micro-antennas for package-scale galvanic isolators based on RF planar coupling. A step-by-step design procedure is proposed, which aims at the maximization of the weak electromagnetic coupling between the RX and TX antennas integrated on side-by-side co-packaged chips to enable both high isolation rating and common-mode transient immunity thanks to the high dielectric strength and low capacitive parasitics of a molding compound-based galvanic barrier, respectively. Micro-antenna design guidelines are drawn, highlighting the main relationship between coil coupling performance and their layout parameters, which are often in contrast with respect to traditional integrated inductor ones.
Land Suitability for Biological Wastewater Treatment in Lebanon and the Litani River Basin Using Fuzzy Logic and Analytical Hierarchy Process
Authors: Kallas Georgio , Palacios-Rodríguez Guillermo , Kattar Salim
Published: January 2022

Biological wastewater treatment (BWWT) has been demonstrated to be a suitable procedure to degrade organic pollutants by utilizing natural processes. This paper presents a validated model to map land suitability for BWWT systems under the climatic conditions of Lebanon and the Litani River basin, using the Geographic Information System (GIS) and a machine learning approach for the Litani River Basin and Lebanon. The model was validated using fuzzy theory and the analytic hierarchy process (AHP) modeling theory, and a final suitability map was created in Lebanon that combined potential areas for Biological Wastewater Treatment (BWWT) based on particular criteria. Results show that spatial distribution of the suitable areas for BWWT sites differs for each of the criteria and the total extent of these potential areas is 162.94 km2 all over Lebanon and 42.62 km2 in the Litani basin areas. This area covers around 1.55% of the Lebanese areas and can help more than 30 regions while the total number of beneficiaries can reach a minimum of 60,000 and a maximum of 180,000 which represents between 1.5% and 3.75% of the total population. These potential areas are identified through land suitability classes to sustain the remaining BWWT areas and can contribute to the riparian forest ecosystem and mitigate the impact of climate change.
Experimental Approach Alters N and P Addition Effects on Leaf Traits and Growth Rate of Subtropical Schima superba (Reinw. ex Blume) Seedlings
Authors: Ye Xuemin , Wang Fangchao , Hu Xiaofei , Lin Yong , Sun Rongxi , Liang Xingyun , Chen Fusheng
Published: January 2022

Nitrogen (N) and/or phosphorus (P) addition has controversial effects on tree functional traits and growth; however, this experimental approach may clarify these controversial results. In this study, field and pot experiments were designed with +N (100 kg N ha−1 yr−1), +P (50 kg P ha−1 yr−1), +NP (100 kg N plus 50 kg P ha−1 yr−1), and a control (no N or P addition) to comparatively investigate the effects of N and P addition on 24 leaf traits and the growth rate of Schima superba (Reinw. ex Blume ) seedlings in subtropical China. We found that the experimental approach alters N and P addition effects on leaf traits and tree growth. Nitrogen addition strongly altered leaf biochemical and physiological traits and limited tree growth compared to P addition in the pot experiment, while the effects of N and P addition on leaf traits and tree growth were weaker in the field, since the seedlings might be mainly limited by light availability rather than nutrient supplies. The inference from the pot experiment might amplify the impact of N deposition on forest plants in complicated natural systems. These findings will help guide refining pot fertilization experiments to simulate trees in the field under environmental change. Future directions should consider reducing the confounding effects of biotic and abiotic factors on fertilization in the field, and refinement of the control seedlings’ genetic diversity, mycorrhizal symbiont, and root competition for long-term fertilization experiments are required.
Effects of Chitosan and Duck Fat-Based Emulsion Coatings on the Quality Characteristics of Chicken Meat during Storage
Authors: Shin Dong-Min , Kim Yea-Ji , Yune Jong-Hyeok , Kim Do-Hyun , Kwon Hyuk-Cheol , Sohn Hyejin , Han Seo-Gu , Han Jong-Hyeon , Lim Su-Jin , Han Sung-Gu
Published: January 2022

Chicken meat is a popular food commodity that is widely consumed worldwide. However, the shelf-life or quality maintenance of chicken meat is a major concern for industries because of spoilage by microbial growth. The aim of this study was to evaluate the effects of chitosan and duck fat-based emulsion coatings on the quality characteristics and microbial stability of chicken meat during refrigerated storage. The coated chicken meat samples were as follows: control (non-coated), DFC0 (coated with duck fat), DFC0.5 (coated with duck fat and 0.5% chitosan), DFC1 (coated with duck fat and 1% chitosan), DFC2 (coated with duck fat and 2% chitosan), and SOC2 (coated with soybean oil and 2% chitosan). The results showed that the apparent viscosity and coating rate were higher in DFC2 than in other groups. Physicochemical parameters (pH, color, and Warner–Bratzler shear force) were better in DFC2 than those in other groups during 15 days of storage. Moreover, DFC2 delayed lipid oxidation, protein deterioration, and growth of microorganisms during storage. These data suggest that chitosan-supplemented duck fat-based emulsion coating could be used to maintain the quality of raw chicken meat during refrigerated storage.
Comparison the Structural, Physicochemical, and Prebiotic Properties of Litchi Pomace Dietary Fibers before and after Modification
Authors: Li Yina , Yu Yuanshan , Wu Jijun , Xu Yujuan , Xiao Gengsheng , Li Lu , Liu Haoran
Published: January 2022

Litchi pomace, a by-product of litchi processing, is rich in dietary fiber. Soluble and insoluble dietary fibers were extracted from litchi pomace, and insoluble dietary fiber was modified by ultrasonic enzymatic treatment to obtain modified soluble and insoluble dietary fibers. The structural, physicochemical, and functional properties of the dietary fiber samples were evaluated and compared. It was found that all dietary fiber samples displayed typical polysaccharide absorption spectra, with arabinose being the most abundant monosaccharide component. Soluble dietary fibers from litchi pomace were morphologically fragmented and relatively smooth, with relatively high swelling capacity, whereas the insoluble dietary fibers possessed wrinkles and porous structures on the surface, as well as higher water holding capacity. Additionally, soluble dietary fiber content of litchi pomace was successfully increased by 6.32 ± 0.14% after ultrasonic enzymatic modification, and its arabinose content and apparent viscosity were also significantly increased. Further, the soluble dietary fibers exhibited superior radical scavenging ability and significantly stimulated the growth of probiotic bacterial species. Taken together, this study suggested that dietary fiber from litchi pomace could be a promising ingredient for functional foods industry.
Comparative Numerical Study of Spline-Based Numerical Techniques for Time Fractional Cattaneo Equation in the Sense of Caputo–Fabrizio
Authors: Yaseen Muhammad , Nisa Arif Qamar Un , George Reny , Khan Sana
Published: January 2022

This study focuses on numerically addressing the time fractional Cattaneo equation involving Caputo–Fabrizio derivative using spline-based numerical techniques. The splines used are the cubic B-splines, trigonometric cubic B-splines and extended cubic B-splines. The space derivative is approximated using B-splines basis functions, Caputo–Fabrizio derivative is discretized, using a finite difference approach. The techniques are also put through a stability analysis to verify that the errors do not pile up. The proposed scheme’s convergence analysis is also explored. The key advantage of the schemes is that the approximation solution is produced as a smooth piecewise continuous function, allowing us to approximate a solution at any place in the domain of interest. A numerical study is performed using various splines, and the outcomes are compared to demonstrate the efficiency of the proposed schemes.
Gender and Nominal Power in Multilateral Bargaining
Authors: Maaser Nicola , Paetzel Fabian , Traub Stefan
Published: January 2022

In many bargaining situations, the distribution of seats or voting weights does not accurately reflect bargaining power. Maaser, Paetzel and Traub (Games and Economic Behavior, 2019) conducted an experiment to investigate the effect of such nominal power differences in the classic Baron–Ferejohn model. This paper re-analyzes the data from that experiment, looking at gender differences in bargaining behavior and in the effect of nominal weights. We find that women and men differ in particular with respect to the proposed distribution of payoffs and coalition size. By contrast, nominal weights have only minor gender-specific effects.
Running across the Silurian/Devonian Boundary along Northern Gondwana: A Conodont Perspective
Authors: Ferretti Annalisa , Corriga Maria Giovanna , Slavík Ladislav , Corradini Carlo
Published: January 2022

The Global Stratotype Section and Point (GSSP) of the Silurian/Devonian boundary, Lower Devonian Series and Lochkovian Stage was formally placed in 1977 at Klonk, in the Czech Republic, at the first appearance of the graptolite Uncinatograptus uniformis uniformis (Přibyl). However, since then, correlation of this limit has been often hampered in carbonate facies where graptolites are uncommon or totally absent. A large calcareous deposition occurred at the Silurian/Devonian boundary along the northern and peri-Gondwana margin, thus representing an ideal location to select and test a possible additional biostratigraphic marker of the limit among conodonts. The first appearance of Caudicriodus hesperius almost simultaneously at the base of the Devonian in Bohemia, the Carnic Alps, Sardinia, Morocco and elsewhere indicates that this taxon is the conodont that best approximates the beginning of the Period. The first or last appearance of other species (e.g., Ozarkodina confluens, Zieglerodina klonkensis, Z. remscheidensis and Caudicriodus woschmidti) may help to recognise the boundary as well.
Disparities in Health Financing Allocation among Infectious Diseases in Ebola Virus Disease (EVD)-Affected Countries, 2005–2017
Authors: Shimizu Kazuki , Checchi Francesco , Warsame Abdihamid
Published: January 2022

The Ebola virus disease (EVD) outbreaks impacted the population health due to overstretched health systems and disrupted essential health services. Despite a call to achieve equal financial allocation depending on public health needs, there has been scant examination of the fairness of investment among infectious diseases. This study analyzes the extent to which equitable development assistance for health (DAH) has been provided in accordance with disease burden in EVD-affected countries. Estimates of disability-adjusted life years (DALYs) in the Global Burden of Disease (GBD) Study 2017 and DAH Database 1990–2019 in 2005–2017 were analyzed by disease category: vaccine-preventable diseases (VPDs), HIV/AIDS, malaria, tuberculosis, and EVD. HIV/AIDS generally recorded higher ratios of DAH per DALYs (DAH/DALYs). Malaria and tuberculosis showed different trends by country, and VPDs generally presented lower ratios. In West Africa in 2013–2016, DAH/DALYs surged in EVD and fluctuated in HIV/AIDS and malaria. Tuberculosis and VPDs consistently recorded lower ratios. To achieve the risk reduction during and after health emergencies, optimal funding allocation between diseases based on the disease burden is warranted in the pre-emergency period, along with measurement of immediate health needs of populations in real-time during an emergency.
White Blood Cells, Platelets, Red Blood Cells and Gas Bubbles in SCUBA Diving: Is There a Relationship?
Authors: Cialoni Danilo , Brizzolari Andrea , Barassi Alessandra , Bosco Gerardo , Pieri Massimo , Lancellotti Valentina , Marroni Alessandro
Published: January 2022

(1) Background: SCUBA diving can influence changes of several hematological parameters (HP) but the changes of HP in the decompression phases are still unclear. The aim of this study was to investigate any possible relationship between HP and predisposition to inert gas bubble formation after a single recreational dive. (2) Methods: Blood, obtained from 32 expert SCUBA divers, was tested for differences in white blood cells (WBC), granulocytes (GRAN), lymphocytes (LYM), and monocytes (MONO), red blood cells (RBC), and platelets (PLT) between bubblers (B) and non-bubblers (NB). (3) Results: We found inter-subject differences in bubble formation (considering the same diving profile performed by the divers) and a statistically significant higher number of total WBC, GRAN and LYM in NB as compared to the B divers in the pre and in the post diving sample, while no statistical differences were found for MONO and PLT. In addition, we did not find any statistically significant difference between NB and B in RBC. (4) Conclusions: Our results, even if in absence of investigated anti-inflammatory markers, could indicate a relationship between low WBC numbers and bubble formation. This aspect may explain a possible cause of inter-subject differences in bubble formation in divers performing the same dive profile.
Effectiveness of a Mobile Wellness Program for Nurses with Rotating Shifts during COVID-19 Pandemic: A Pilot Cluster-Randomized Trial
Authors: Ha Yeongmi , Lee Sang-Ho , Lee Dong-Ha , Kang Young-Hun , Choi Woonjoo , An Jinung
Published: January 2022

Nurses with rotating shifts, including night shifts, have suffered from low physical activity during the COVID-19 pandemic and lower sleep quality due to the disruption of their circadian rhythm. This study aimed to develop and examine the effectiveness of a mobile wellness program on daily steps, sleep quality, exercise self-efficacy, intrinsic motivation for exercise, self-rated fatigue, and wellness. A cluster randomized controlled trial design was used to examine the effectiveness of the mobile wellness program for nurses with rotating shifts. Sixty nurses from one university hospital participated and were allocated to an intervention group and a control group. The intervention group received a 12-week mobile wellness program to improve their physical activity and sleep quality, and the control group was only given a Fitbit to self-monitor their health behaviors. There were significant differences between the two groups in daily steps (p = 0.000), three components (subjective sleep quality, sleep disturbance, daytime dysfunction) of the PSQI, exercise self-efficacy, intrinsic motivation for exercise, and wellness. In conclusion, this study provides meaningful information that the mobile wellness program using Fitbit, online exercise using Zoom, online health coaching on a Korean mobile platform, and motivational text messages effectively promoted physical activity and sleep quality for nurses with rotating shifts during the COVID-19 pandemic.
A Systematic Review and Meta-Analysis of Symptoms of Anxiety, Depression, and Insomnia in Spain in the COVID-19 Crisis
Authors: Zhang Stephen X. , Chen Richard Z. , Xu Wen , Yin Allen , Dong Rebecca Kechen , Chen Bryan Z. , Delios Andrew Yilong , Miller Saylor , McIntyre Roger S. , Ye Wenping , Wan Xue
Published: January 2022

Background: General population, frontline healthcare workers (HCWs), and adult students in Spain are at risk of anxiety, depression, and insomnia symptoms during the COVID-19 crisis. A meta-analysis of the individual studies on these symptoms would provide systematic evidence to aid policymakers and researchers in focusing on prevalence, risk, and best interventions. Objective: This paper aims to be the first meta-analysis and systematic review to calculate the prevalence of anxiety, depression, and insomnia symptoms in Spain’s adult population (general population, frontline healthcare workers (HCWs), and adult students) during the Covid-19 epidemic. Method: Random-effect meta-analysis was used to estimate the prevalence of anxiety, depression, and insomnia. Results: The meta-analysis includes 28 studies with 38 individual samples in Spain. The pooled prevalence of anxiety symptoms in 22 studies comprising a sample population of 82,024 was 20% (95% CI: 15–25%), that of depression symptoms in 22 articles with a total sample comprising 82,890 individuals was 22% (95% CI: 18–28%), and that of insomnia symptoms in three articles with a sample population of 745 was 57% (95% CI: 48–66%. Conclusions: The accumulative evidence reveals that adults in Spain suffered higher prevalence rates of mental symptoms during the COVID-19 crisis, with a significantly higher rate relative to other countries such as China. Our synthesis also reveals a relative lack of studies on frontline and general HCWs in Spain.
School-Based Physical Activity Intervention: A Qualitative Process Evaluation of a Feasibility Trial in Yangzhou, China
Authors: Wang Haiquan , Zhou Yanxing , Blake Holly , Chattopadhyay Kaushik
Published: January 2022

Background: There is an urgent need for children in China to increase their physical activity levels. We first developed a 16-week school-based behavior change intervention based on the Behavior Change Wheel and Theoretical Domains Framework. We then conducted a cluster feasibility non-randomized controlled trial (RCT) among children in Yangzhou, China. Aim: This qualitative process evaluation was embedded within the cluster feasibility non-RCT and aimed to: (1) explore the experiences and perceptions of participants and providers in the intervention and trial; and (2) generate recommendations to inform a future intervention and full-scale cluster RCT. Methods: A qualitative study, using semi-structured interviews with trial participants (n = 20 children: 10 intervention, 10 control), parents (n = 20), and health education providers (n = 2), was conducted in two public schools in Yangzhou, China. Interviews were audio-recorded, transcribed, and translated verbatim from Mandarin to English. Data were analyzed using thematic analysis. Results: Findings believed to reflect experiences and perceptions of participants in the intervention and the trial are presented as eight major themes: (1) perceived high efficacy of the intervention components to help children become more active, (2) appreciation of the intervention features, (3) factors that facilitated or impeded intervention attendance and delivery, (4) positive experiences and feelings gained through the data collection process, (5) satisfaction regarding the organization and implementation of the trial, (6) influences of personal beliefs and emotional responses to the trial, (7) social influences on participatory decision-making, and (8) key barriers to consider regarding the recruitment of participants. Conclusions: The intervention and trial methods were acceptable to children, parents, and health education providers. School-based behavior change intervention was perceived to be a useful approach to increase physical activity in children aged 10–12 years in China. However, there were barriers to intervention delivery and engagement that should be considered when designing a future cluster RCT to assess the intervention efficacy.
AEducaAR, Anatomical Education in Augmented Reality: A Pilot Experience of an Innovative Educational Tool Combining AR Technology and 3D Printing
Authors: Cercenelli Laura , De Stefano Alessia , Billi Anna Maria , Ruggeri Alessandra , Marcelli Emanuela , Marchetti Claudio , Manzoli Lucia , Ratti Stefano , Badiali Giovanni
Published: January 2022

Gross anatomy knowledge is an essential element for medical students in their education, and nowadays, cadaver-based instruction represents the main instructional tool able to provide three-dimensional (3D) and topographical comprehensions. The aim of the study was to develop and test a prototype of an innovative tool for medical education in human anatomy based on the combination of augmented reality (AR) technology and a tangible 3D printed model that can be explored and manipulated by trainees, thus favoring a three-dimensional and topographical learning approach. After development of the tool, called AEducaAR (Anatomical Education with Augmented Reality), it was tested and evaluated by 62 second-year degree medical students attending the human anatomy course at the International School of Medicine and Surgery of the University of Bologna. Students were divided into two groups: AEducaAR-based learning (“AEducaAR group”) was compared to standard learning using human anatomy atlas (“Control group”). Both groups performed an objective test and an anonymous questionnaire. In the objective test, the results showed no significant difference between the two learning methods; instead, in the questionnaire, students showed enthusiasm and interest for the new tool and highlighted its training potentiality in open-ended comments. Therefore, the presented AEducaAR tool, once implemented, may contribute to enhancing students’ motivation for learning, increasing long-term memory retention and 3D comprehension of anatomical structures. Moreover, this new tool might help medical students to approach to innovative medical devices and technologies useful in their future careers.
Simultaneous Detection of Four Main Foodborne Pathogens in Ready-to-Eat Food by Using a Simple and Rapid Multiplex PCR (mPCR) Assay
Authors: Boukharouba Aya , González Ana , García-Ferrús Miguel , Ferrús María Antonia , Botella Salut
Published: January 2022

The increasing consumption of organic or ready-to-eat food may cause serious foodborne disease outbreaks. Developing microbiological culture for detection of food-borne pathogens is time-consuming, expensive, and laborious. Thus, alternative methods such as polymerase chain reaction (PCR) are usually employed for outbreaks investigation. In this work, we aimed to develop a rapid and simple protocol for the simultaneous detection of Escherichia coli (E coli), Listeria monocytogenes (L. monocytogenes), Staphylococcus aureus (S. aureus) and Salmonella enterica (S. enterica), by the combination of an enrichment step in a single culture broth and a multiplex PCR (mPCR) assay. The effectiveness of several enrichment media was assessed by culture and PCR. Buffered peptone water (BPW) was selected as the optimum one. Then, mPCR conditions were optimized and applied both to pure co-cultures and artificially inoculated food samples (organic lettuce and minced meat). In the culture medium inoculated at 100 CFU/mL, mPCR was able to detect the four microorganisms. When performed on artificially food samples, the mPCR assy was able to detect E. coli, S. enterica, and L. monocytogenes. In conclusion, BPW broth can effectively support the simultaneous growth of E. coli, S. aureus, L. monocytogenes, and S. enterica and could be, thus, used prior to a mPCR detection assay in ready-to-eat food, thereby considerably reducing the time, efforts and costs of analyzes.
Urban Land Expansion from Scratch to Urban Agglomeration in the Federal District of Brazil in the Past 60 Years
Authors: Li Zhichao , Gurgel Helen , Li Minmin , Dessay Nadine , Gong Peng
Published: January 2022

Empirical studies of urban expansion have increased rapidly in recent decades worldwide. Previous studies mainly focused on cities in China, the United States or African countries, with Brazilian cities receiving less attention. Moreover, such studies are rare in purpose-built cities. Taking the urban expansion from scratch (1960) to urban agglomeration (2015) in the Federal District of Brazil (FDB) as an example, this study aims to quantify the magnitude, patterns, modes, types and efficiency of urban land expansion and attempts to reveal some implications within sustainable urban expansion thinking. Annual expansion, landscape metrics, local Moran’s I index, area weighted mean expansion index, and land-use efficiency were computed. The suitability of diffusion–coalescence theory and the impact of population growth and urban development policies on urban expansion were discussed. Urban land continuously expanded and became more fragmented during 1960–2015, which mainly occurred in SSW and WSW directions. Urban land evolved in a polycentric way. Edge expansion was identified as the stable contributor, and the importance of infilling and spontaneous growth alternated. Urban expansion in this region supported the diffusion–coalescence theory. Population growth promoted urban expansion, and the creation of peripheral urban nuclei and their development were associated with the urban expansion and the changes in urban land structure. This study adds new empirical evidence of urban expansion to Brazil urbanization, and compact urbanization, population control, and efficient urban land use should be considered in the future.
Motives and Barriers to Exercise Training during Hospitalization in Patients with Type 2 Diabetes: A Cross-Sectional Study
Authors: Molsted Stig , Kusk Lasse , Esbensen Søren Mingon , Mohr Thomas Martin , Vind Malene Bang , Hess Camilla , Bandholm Thomas , Kristensen Morten Tange , Flege Cornelie Mølsted , Kristensen Peter Lommer
Published: January 2022

Background: Exercise training during hospitalization may prevent loss of physical function and hyperglycemia in patients with type 2 diabetes. The aim of this study was to assess motives and barriers to exercise training in hospitalized patients with type 2 diabetes. Methods: Data were collected using a questionnaire about motives and barriers to exercise training during hospitalization. Additional data for clinical characteristics of the participants were collected from patient records. Results: 79 patients participated (mean ± SD age 72 ± 12 years; 42% women), of whom 25% had a low level of education and 46% lived alone. The median (IQR) length of the stay was 6 (4–10) days. A total of 67% of the participants wished to be more physically active. Walking as exercise was preferred by 51%. The most frequently reported barriers to exercise training were bodily pain (48%) and dizziness (42%). Low vs. high level of education, and living alone vs. being married/living with a partner were associated with reduced odds of a wish to be more physically active, odds ratio (OR) 0.15 [95% CI 0.03; 0.76], p = 0.022, and 0.21 [0.05; 0.82], p = 0.025, respectively. Conclusion: Two out of three hospitalized patients with type 2 diabetes wished to be more physically active during admission. Bodily pain was a barrier to exercise training and needs attention in training programs. As a low level of education was associated with reduced odds of a wish to be more active, a strategy to include all patients in training programs which considers social inequality is needed.