bluuebunny/crossref_metadata_2025 huggingface dataset:
The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Osteoporosis
Authors: Sun Huijun , Li Hao , Wang Changyuan , Jin Yue , Cai Yuanqing , Liu Mozhen
Published: February 2022

Background: Osteoporosis (OP) is a common bone disease of old age resulting from the imbalance between bone resorption and bone formation. circRNAs are a class of endogenous noncoding RNAs (ncRNAs) involved in gene regulation and may play important roles in the development of OP. Here, we aimed to discover the OP‑related circRNA-miRNA-mRNA (ceRNA) network and the potential mechanisms.Results: Six datasets were obtained from GEO databases and the differentially expressed genes, circRNAs, and miRNAs were screened out from these datasets. Then, combined with the predicted target miRNAs and target genes, a total of 7 target circRNAs, 5 target miRNAs, 38 target genes, and a ceRNA network was constructed. Then RNA-seq verification by using total RNA isolated from the femurs of normal and oophorectomy Wistar rats indicated that MFAP5, CAMK2A, and RGS4 were closely associated with osteoporosis. Function enrichment analysis indicated that the target circRNAs, miRNAs, and genes were involved in the process of MAPK cascade, hormone stimulus, cadherin binding, rRNA methyltransferase, PI3K-Akt signaling pathway, and Vitamin digestion and absorption, et.al. Then a circRNA-miRNA-hub gene subnetwork was constructed and the RT-qPCR analysis of human bone tissues from the femoral head was used to confirm that the transcription of hsa_circR_0028877, hsa_circR_0082916, DIRAS2, CAMK2A, and MAPK4 showed a significant correlation with osteogenic genes. Besides, the two axes of hsa_circR_0028877 - hsa-miR-1273f - CAMK2A and hsa_circR_0028877 - hsa-miR-1273f - DIRAS2 conformed to be closely associated with OP. Additionally, by constructing a drug-target gene network, RKI-1447, FRAX486, Hyaluronic, and Fostamatinib were identified as therapeutic options for OP.Conclusions: Our study revealed the potential links between circRNAs, miRNAs, and mRNAs in OP, suggesting that the ceRNA mechanism may contribute to the occurrence of OP.
Bcl-2 and Noxa are potential prognostic indicators for patients with gastroenteropancreatic neuroendocrine neoplasms
Authors: Yu Guo , Lin Zhang , Ning Zhang , Qiuyun Luo , Man Liu , Dajun Yang , Chen Jie
Published: February 2022

Purpose Bcl-2 family of proteins are of great significance in the pathogenesis and development of tumor. In this study, the relationship between the expression of Bcl-2 family proteins and clinicopathological features and prognosis of NENs were further investigated. Methods 105 Patients diagnosed with gastroenteropancreatic NENs (GEP-NENs) with the paraffin specimen of the tumor available were retrospectively included, immunohistochemistry (IHC) was performed to detect the expression of Bcl-2 family proteins in paraffin-embedded samples. Student’s t test and Chi-square test were applied to compare the difference of quantitative and categorical variables, respectively. Prognosis analysis was conducted according to Kaplan⁃Meier method. Univariate COX and multivariate COX regression analysis were used to screen out the independent prognostic factors. Results The IHC score of Bcl-2 was significant higher in neuroendocrine carcinomas (NECs) patients (65.6% vs. 38.4%, P = 0.010), while higher IHC score of Noxa was more common in neuroendocrine tumors (NETs) patients (49.3% vs. 25.0%, P = 0.020). Survival analysis suggested that patients with higher Bcl-2 expression and lower Noxa expression had worse survival rate (42.9% vs. 73.2%, P < 0.001; 42.6% vs. 81.8%, P < 0.001). Multivariate cox analysis indicated that high Bcl-2 expression was an independent factor associated with poor DFS (hazard ratio [HR]: 2.661; 95% confidence interval [CI]: 1.385–5.110) and poor OS (HR: 3.205; 95% CI: 1.587–6.473; P = 0.001), while higher Noxa expression was associated with improved DFS (HR:0.324; 95% CI: 0.147–0.713) and better OS (HR: 0.293; 95% CI: 0.126–0.684). Conclusion Higher expression of Bcl-2, and lower expression of Noxa were associated with unfavorable prognosis of GEP-NEN patients.
Frequency Distribution Of ABO Alleles In A Malaria-Endemic Area Of Pakistan
Authors: Rasheed Seher , Moiz Bushra
Published: February 2022

Background: Falciparum malaria has exerted adaptive responses in mankind over a period of years for their survival advantage. Red cell disorders like thalassemia, Glucose 6 phosphate dehydrogenase deficiency, sickle cell anemia parallel the endemicity of malaria and are associated with malaria resistance. Distribution of ABO types had been linked to the prevalence of malaria. Pakistan has a huge burden of malaria, and the commonly reported blood phenotype is O. Despite this, no local information is available for allelic frequency of blood types. The study aimed in determining the frequency of ABO blood group alleles in a malaria-endemic area of Pakistan.Methods: A total of 90 blood samples from healthy blood donors residing in Southern Pakistan were included in this study. Serological testing was performed using gel column agglutination and the conventional tube method. DNA extraction was performed from whole blood using Extra-gene I kit) followed by molecular genotyping by polymerase chain reaction, using sequence-specific primers (SSP-PCR) BAGene ABO kits. Results: Of 90 samples, O phenotype constituted 33.3% (n=30) of the total ABO types. Twelve genotypes were identified in a combination of 6 common ABO alleles. Allele frequency of ABO*O.01.01 was highest at 0.4944 followed by ABO*B.01 (allelic frequency of 0.2555) and ABO*A1.01 (allelic frequency 0.1666). Conclusion: This study demonstrated the ABO*O.01.01 as the most frequent ABO allele in a malaria-endemic area at Pakistan and may be considered as an adaptive response to malaria. We need large scale studies for determining ABO alleles in different regions of the country depending on variability in malaria transmission.
Roseicella aquatilis sp. nov., isolated from freshwater lake
Authors: du zongjun , Zhang Dandan , Zhao Ya-Nan , He Rui-Han , Yan Yu-Qi
Published: February 2022

A novel Gram-stain-negative, non-motile, ellipsoidal-shaped, red-pigmented, facultatively aerobic strain designated NE82T, was isolated from mud sample from Jiugongli Lake in Inner Mongolia Autonomous Region, China. Optimal growth occurred at 28–33°C (range 15–42°C) and pH 7.0-7.5 (range 5.5–8.5) with 0% (w/v) NaCl (range 0–1.0%). Cells of strain NE82T were 0.4–0.9 µm in diameter, catalase-positive and oxidase-negative. Q-10 was the sole respiratory quinone and the major cellular fatty acids (> 10%) in strain NE82T were summed feature 8 (C18:1 ω7c and C18:1 ω6c). The polar lipids of strain NE82T were phosphatidylethanolamine, phosphatidylcholine, phosphatidylglycerol, an unidentified aminophospholipid and four unidentified phospholipids. The G + C content of the genomic DNA was 72.0 mol%. Based on the 16S rRNA gene sequence, strain NE82T, showed the highest similarity (97.2%) to Roseicella frigidaeris DB1506T within the family Acetobacteraceae, represents a novel species of the genus Roseicella, for which the name Roseicella aquatilis sp. nov. is proposed. The type strain is NE82T (=KCTC 62412T༝MCCC 1H00292T).
Artemisia Annua Extracts Improve the Cognitive Deficits and Reverse the Pathological Changes of Alzheimer’s Disease via Regulating YAP Signaling
Authors: Zhou Wenshu , Lei Bingxi , Yang Chao , Silva Marta , Xing Xingan , Zheng Wenhua
Published: February 2022

Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by a progressive loss of memory and cognitive functions, language disorders, functional and behavioral alterations. The neurotoxicity is associated with the aggregation of β-amyloid (Aβ) plaques and the downstream pathologies events such as Tau hyperphosphorylation, oxidative stress, neuroinflammation, and mitochondrial dysregulation play critical roles in the development of AD. With no effective treatment available for the prevention and treatment of AD, the search for new therapies has become the focus of many researchers.Methods: Artemisia annua extracts were extracted and a water-soluble artemisia annua extract (Ex1) was used in treatment for 3xTg AD mice via oral administration. Cognitive functional recovery, Aβ accumulation, hyper-tau-phosphorylation, and the release of inflammatory factors and apoptosis were assessed three months after the treatment. In vitro, PC12 cells were incubated with 8 μM Aβ1-42 with or without Ex1 at different concentrations for 24h. ROS levels, mitochondrial membrane potential, caspase-3 activity, neuronal cell apoptosis, inflammation, and the phosphorylation of Tau, as well as involvement in the signaling pathway, were assessed by using biological technology. Results: Oral administration of Ex1 to AD 3xTg mice significantly improved the cognitive deficits, reduced Aβ accumulation, hyper-tau-phosphorylation, and the release of inflammatory factors and apoptosis. Ex1 promoted the survival and proliferation of neural progenitor cells (NPS), increased the expression of synaptic proteins and neuronal cell survival. Similarly, Ex1 significantly reversed the Aβ1-42-induced increase of ROS levels, caspase-3 activity, neuronal cell apoptosis, inflammation, and the phosphorylation of tau in vitro.Conclusions: These findings suggest that a water-soluble artemisia annua extract (Ex1) may be a new multi-target anti-AD drug with potential use in the prevention and treatment of Alzheimer’s disease.
System GMM-based Model for Monitoring Joint Impact of ICT-infrastructure, Financial Development, and Trade-openness on Economic-growth
Authors: Kumari Reenu , Singh Sunil Kumar
Published: February 2022

This study has analyzed the joint impact of information communications technology (ICT) Infrastructure, financial development (FD), and trade openness (TO) on economic growth (EG). We have used the data from 85 countries (including 27 low-income and 58 high-income countries). In this sample, we have collected the data from the year 2000-2019. We have framed hypotheses for samples and applied OLS, fixed effect regression (FER), and GMM method. Our results provide evidence that (a) ICT infrastructure is a significant and positive interpreter of economic growth, (b) Individual consideration of trade openness and financial development is insignificant and negative for both groups of countries, ICT infrastructure requires more financial development and trade openness in low-income countries (LICs) in comparison to high-income countries(HICs), (c) ICT infrastructure-financial development-trade openness nexus differ significantly for both groups of countries. Our study acquiesces that variables are grave drivers of any economy and comprehensive growth in low-income countries. In this work, we have also discussed policy implications.
Distinct Genomic Features Between Osteosarcomas Firstly Metastasing to Bone and to Lung
Authors: Xie Lu , Cai Zhenyu , Lu Hezhe , Meng Fanfei , Zhang Xin , Luo Kun , Su Xiaoxing , Lei Yan , Xu Jiuhui , Lou Jingbing , Wang Han , Du Zhiye , Wang Yunfan , Li Yuan , Ren Tingting , Xu Jie , Sun Xin , Tang Xiaodong , Guo Wei
Published: February 2022

Background: Osteosarcoma (OS) initially metastasing to bone only shows distinct biological features compared to osteosarcoma that firstly metastasizes to the lung, which suggests us underlying different genomic pathogenetic mechanism. However related-study is lacking.Methods: We analyzed whole-exome sequencing (WES) data for 38 metastatic OS patients with different relapse patterns. Multiplex Immunohistochemistry was also applied to investigate the immune- microenvironment. We tried to redefine disease subclassifications for OS based on genetic alterations to guide treatment strategies, and we correlated these genetic profiles with clinical treatment courses and prognosis to elucidate potential evolving cladograms.Results: We investigated whole-exome sequencing of 12/38 patients with high-grade OS (31.6%) with initial bone metastasis (group A) and 26/38 (68.4%) with initial pulmonary metastasis (group B), of whom 15/38 (39.5%) had paired samples of primary lesions and metastatic lesions for these two cohorts with different relapse patterns. We found that osteosarcoma in group A mainly carries single-nucleotide variations while those in group B mainly exhibits structural variants. Additionally, osteosarcoma in group A displayed better immunogenicity, including a higher tumor mutation burden and neoantigen load and more tertiary lymphoid structures in tumor microenvironment.Conclusions: Osteosarcoma with different relapse patterns has distinct genomic landscapes. This study suggests that osteosarcoma with mainly single-nucleotide variations other than structural variants might exhibit biological behavior predisposing toward bone metastases; immunotherapy is a promising therapeutic option for this group of patients.Trial registrationThis trial was registered in the Medical Ethics Committee of Peking University People’s Hospital on June 25th, 2019 (Institutional Review Board, IRB, number of 2019PHB139-01). The trial was registered in Clinicaltrials.gov with identifier no. NCT03997747.
Deep Multilayer Perceptron Wind Speed Estimation Based Artificial Immune System For Power Generation Prediction
Authors: T Vinoth Kumar , N Deepa S , S Tamizharasi , N Yogambal Jayalashmi
Published: February 2022

Wind energy is fast developing energy resource as it is renewable, pollution free and abundant. The nonlinear and fluctuation of wind are large demand for enhancing the reliability and accuracy of the power system that combines the wind speed. With an exact wind speed data, power system operators predict the power output for system planning and scheduling. Wind speed prediction is an essential factor in forecasting to attain the efficient wind power utilization. But, the prediction time and accuracy performance was not improved using existing techniques. In order to address this problem, Deep Multilayer Perceptron Neural Network based Clonal Selective Optimization (DMLPNN-CSO) technique is introduced. The main objective of DMLPNN-CSO technique is to improve the performance of power generation prediction through wind speed estimation with higher accuracy based on mean air temperature, relative humidity and vapor pressure data. DMLPNN-CSO technique comprises two processes, namely deep multilayer perceptron neural network and clonal data selection algorithm. Initially in DMLPNN-CSO technique, wind turbine is considered as the input and given to the input layer in deep multilayer perceptron neural network. Wind turbine information is extracted and given to the hidden layer 1. In this layer, data preprocessing is performed through the median filter for removing unnecessary data. After that, the preprocessed data is given to the hidden layer 2 to estimate the wind speed. The estimated values are collected and get matched with the pre-stored values in the output layer by using softsign activation function. After estimation of wind speed, the optimal data gets selected by using clonal data selection algorithm for predicting the power generation. Clonal data selection algorithm performs the sorting, cloning and guassian mutation for finding the optimal value in power generation prediction. This in turn helps to improve prediction accuracy and reduce the time consumption. Experimental evaluation of proposed DMLPNN-CSO technique is carried out with respect to number of wind turbine data and data samples. The results showed that DMLPNN-CSO technique produces higher prediction accuracy and wind speed estimation rate when compared to state-of-the-art works.
Fixed Broadband Take-Up in Europe
Authors: Leogrande Angelo , Magaletti Nicola , Cosoli Gabriele , Massaro Alessandro
Published: February 2022

In this article the value of “Fixed Broadband Take Up” in Europe is investigated. Data are collected from the DESI-Digital Economy and Society Index for 28 countries in the period 2016-2021. Data are analyzed with Panel Data with Fixed Effects and Random Effects. The Fixed Broadband Take-Up value is positively associated with the value of "Connectivity", "Human Capital", "Desi Index", "Fast BB NGA Coverage", "Fixed Very High-Capacity Network VHCN coverage". Fixed Broadband Take-Up value is negatively associated with "Digital Public Services for Businesses", "e-Government", "At least Basic Digital Skills", "At Least Basic Software Skills", "Above Basic Digital Skills", "Advanced Skills and Development", "Integration of Digital Technology", "Broadband Price Index", "Mobile Broadband", "Fixed Broadband Coverage". Subsequently the k-Means algorithm optimized by the Silhouette coefficient was used to identify the number of clusters. The analysis shows the presence of the two clusters. Eight different machine learning algorithms were then used to predict the future value of the "Fixed Broadband Take-Up in Europe". The analysis shows that the most efficient algorithm for the prediction is "ANN-Artificial Neural Network" with an estimated value of the prediction equal to 26.39%.
SEGURANÇA DA EQUIPE DE SAÚDE X SEGURANÇA DO PACIENTE EM TEMPOS DE PANDEMIA
Authors: Rodrigues da Silva Adriana
Published: February 2022

Objetivo: Compreender as estratégias para assegurar a segurança das equipes de saúde e do paciente em tempos de pandemia. Método: trata-se de uma revisão integrativa de literatura, desenvolvida no mês de agosto de 2021 através de dados coletados nas bases de dados SciELO; LILACS e BDENF; incluindo sites organizacionais como o Ministério da Saúde, OMS e a OPAS. Fundamentação Teórica: A pandemia COVID-19 trouxe diversos impactos que afetam a saúde ocupacional e do paciente, dentre eles os milhões de óbitos e o comprometimento mental, social e emocional proporcionada por uma emergência em saúde. Resultados: a amostra consistiu em 06 artigos entre os anos de 2020 e 2021, que abordam a temática de segurança do paciente e do profissional de saúde, além da  importância do gestor no enfrentamento das dificuldades perante a pandemia COVID-19. Conclusão: evidenciou-se que o cuidado direcionado à saúde do trabalhador é essencial para a promoção e manutenção da segurança e na garantia da qualidade do serviço, sendo a atuação do gestor essencial nesse processo.
AGENDAMENTO EM CENTROS CIRÚRGICOS: UMA SOLUÇÃO BASEADA NA TEORIA DA CORRENTE CRÍTICA
Authors: Flávio Castro Robson , Liguori Zacchi Marcelo , De Castro Moura Duarte André Luís , Meyer Sanches Lars
Published: February 2022

Objetivo: A pesquisa tem dois objetivos, o primeiro é entender a dinâmica e as razões dos atrasos em um centro cirúrgico (CC) de um hospital de referência, localizado na cidade de São Paulo, e o segundo é propor novas políticas para o processo de agendamento de centros cirúrgicos, baseado na Teoria da Corrente Crítica (TCC).

Método: Para alcançar tais objetivos, foram utilizados o método de Estudo de Caso (YIN, 2014) e a técnica de Simulação de Eventos Discretos. No estudo de caso, foram coletados indicadores de processos, além da realização de entrevistas com gestores de todas as áreas e serviços relacionados ao CC.

Fundamentação teórica: A gestão de centros cirúrgicos é crítica em muitos hospitais, não somente pelos altos custos envolvidos, mas também pela sua complexidade. Os gestores dos CCs são desafiados a reduzirem custos e buscarem melhorias na qualidade dos serviços prestados a pacientes e cirurgiões. A gestão de um CC envolve lidar com incertezas e variabilidades relacionadas com a quantidade e com a duração de cirurgias em um hospital.  O processo de agendamento das cirurgias é crucial para o sucesso desta gestão.

Resultados: Os resultados da simulação mostram que o uso da TCC melhorou significativamente os indicadores do centro cirúrgico estudado. Mesmo mantendo o volume de cirurgias por dia, observou-se uma queda no número de cirurgias iniciando com atrasos, de 94,5% para 58,3%. O atraso médio caiu de 54' para 35', uma redução de 35%.

Conclusões e contribuições: Este trabalho procura propor soluções para gestores hospitalares com potencial efeito na redução de desperdícios nas operações dos CCs, na melhora dos indicadores de qualidade e na satisfação dos atores dos CCs e, por consequência, no aumento dos ganhos financeiros das instituições hospitalares.
HOSPITAIS PRIVADOS NO BRASIL E CANADÁ
Authors: Marques Isabel Cristina Panziera , Serrasqueiro Zélia , Nogueira Fernanda
Published: February 2022

Este estudo tem como objetivo analisar os hospitais privados do Brasil e do Canadá, países que possuem gestão de recursos de saúde díspares, considerando as análises de desempenho realizadas pelos gestores dos hospitais, como suporte à tomadas de decisão de investimento. Realizado um transversal quantitativo, os dados foram analisados através do SPSS Statistic. Os achados revelam a importância do envolvimento, habilidades e capacidades do gestor hospitalar que estão associados as melhores análises de desempenho. Como resultados, as instituições hospitalares foram caracterizadas, os perfis dos gestores destes hospitais foram traçados e foram destacadas as principais análises de desempenho realizadas nos hospitais, bem como a formação da estrutura do capital e os investimentos realizados nos últimos cinco anos por estes hospitais. Verificado, na opinião dos respondentes, se a formação do gestor hospitalar deve ter origem na Medicina. Ao comparar características dos hospitais privados, com diferentes formatos de alocações de recursos e de sistemas de saúde totalmente descentralizado (Canadá) com parcialmente descentralizado (Brasil) este estudo visa compreender a influência dos Sistemas Nacionais de Saúde no desempenho dos hospitais privados.
Financial literacy and business performance among female micro-entrepreneurs
Authors: Julius Tumba Ndaghu , A. Onodugo Vincent , Etim Akpan Ekom , Festus Babarinde Gbenga
Published: February 2022

The poor performance of female entrepreneurs, exemplified in their inability to realize their full potential and compete fairly with their male counterparts owing to financial illiteracy, motivated this study. Therefore, this study examined the effect of financial literacy on business performance among female micro-entrepreneurs. Using the survey research design, data were collected from 247 female entrepreneurs from six states in the North-Eastern region of Nigeria. The hypotheses developed for the study were tested using path modeling-structural equation modeling with the aid of SmartPLS software version 3.2.7. The result revealed that all proxies of financial literacy (financial education, cash forecasting, and bookkeeping have significant effects on business performance of female entrepreneurs. Additionally, the paper revealed that financial education contributed more to the variance in business performance of the female micro-entrepreneurs, this was followed by bookkeeping practices, while cash-forecasting has the least effect on the variance in business performance. This implies that financial education is essential for the success of female micro-entrepreneurs. Thus, this study advocates the need for continuing trainings and workshops for female micro-entrepreneurs on financial concepts such as bookkeeping, cash forecasting, and market volatilities.
Sufism and Kenosis: The Basis of One’s Resilience as a Zoom Politicon
Authors: Novalina Martina , Sabdono Erastus , Samego Indria
Published: February 2022

The COVID-19 pandemic has brought humans into a new civilization, where Zoom meeting is no longer just an application but a changing pattern of human interaction with each other. This change, of course, requires adaptation, and not a few end up having problems due to Work From Home. Zoom applications risked two times of experiencing fatigue in students and four times of experiencing stress and also having issues in disruption of social functioning. This article aims to provide a solution to a person's resilience as a social being in the zoom era (zoom politicon) by applying Sufism and kenosis values. The approach used is library research. Through this study, we can see that some of the values in Sufism and kenosis have become the basis for a person to survive all challenges in life, especially amid fatigue doing activity online. These current values also protect a person from being caught up in a sin that eventually perishes. Human values as a part of zoom politicon must still be put forward to reflect one's spiritual journey to God.
Torsional vibration analysis of a powertrain with a power reflux hydraulic transmission system
Authors: Zhang Zhigang , Wang Huan , Ge Shuaishuai , Li Ming
Published: February 2022

World-wide constraints on the supply of fossil fuel resources exist in conjunction with stringent environmental constraints. Therefore, it is very important to develop advanced technologies to reduce fuel consumption. The transmission efficiency of an automatic vehicle is low because of the torque converter. Hence, in this study, a power reflux hydraulic transmission system (PRHTS) was proposed. It is important to avoid the phenomenon of resonance in a powertrain with a PRHTS, and thus it is necessary that the resonance point of a powertrain with a PRHTS does not exist in the resonance region of the engine. A dynamic and mathematical model of a powertrain with a PRHTS was developed to study the resonance characteristic of the powertrain. The amplitude-frequency characteristic curve of a powertrain for different speed ratios was obtained. The effect of torsional stiffness of the coupling and engine shock absorber on the amplitude-frequency characteristics of a powertrain with a PRHTS were examined. The simulation result indicated that it was necessary to exclude the resonance frequencies of the powertrain with a PRHTS from the operation range of the engine.
Treatment of plantar fasciitis (heel spur) with focused shockwave therapy and superinductial magnetotherapy
Authors: Iordanishvili Andrey K. , Moroz Pavel V. , Bobyntsev Igor’ I.
Published: February 2022

To study the periodontal tissues, inflammatory and dystrophic diseases of which more than 50% of the population of the globe occur, the following methods are used: rheoparadontography, laser Doppler flowmetry, ultrasonic high-frequency Dopplerography (echoosteometry) and others which are often inaccessible for the public health institutions be-cause of the need in special expensive equipment, training and preparation of the equipment. The aim of the work was to correlate the assessment of the periodontal tissues condition in chronic generalized perio-dontitis with the help of modern methods of functional diagnostics and with the help of the test allowing to estimate the gingival capillaries resistance. 152 adult patients 45-56 years old were examined, 36 of them were not diagnosed with perio-dontal pathology, 116 patients had chronic generalized periodontitis of different severity degrees. Capillaroscopy, laser Dop-pler flowmetry, Kulazhenko's test, peripheral blood circulation index in the gingiva were applied in all patients to assess the morphofunctional state of the periodontal tissues. In people suffering from chronic generalized periodontitis the state of the periodontium using the mentioned research methods was also evaluated one month after the completion of the complex treatment. It is shown that the test of Kulazhenko suggested in the last century and the technique of the index evaluation of the peripheral blood circulation in the gingival tissues based on it clearly and reliably correlate with the indices obtained with the help of modern appliances for hemocirculation studies. Therefore, these techniques should retain their relevance for practical dentistry, especially since the use of Kulazhenko's test has a significant positive therapeutic effect on periodontal tissues in its inflammatory pathology, and the use of IPCD allows to objectively assess the effectiveness of therapeutic and preventive measures, including during the dispensary of periodontological patients.
Phage Display in Proteolysis and Signal Transduction
Authors: Gram Hermann
Published: February 2022

The power of the phage display technology relies on the coupling of the functional display of combinatorial peptide or protein libraries with the ability of each member in the library to self-replicate and, at the same time, to encode the primary structure of the displayed polypeptide in its genome. Phage display systems, therefore, reflect the principle of encoded combinatorial chemistry close to perfection. Phage display libraries have extensively been used for the selection of peptides, antibody combining sites or protein variants binding to given structures such as polypeptides, carbohydrates, nucleic acids or small molecular weight compounds. The use of peptide libraries in selecting molecular interaction partners was extensively described in numerous publications and was subject to a variety of review articles in the past. More recently, and in the focus of this review, combinatorial phage libraries have been employed to examine substrate recognition in catalysis and signal transduction. The sensitivity and versatility of phage display for probing molecular recognition and catalysis by enzymes was demonstrated inasmuch as discriminating peptide substrates could be identified for even closely related proteases or tyrosine kinases. Furthermore, the modification of whole phage libraries by tyrosine kinases led to the identification of phosphopeptides specific for Src-homology-2 (SH2) - and phosphotyrosine-binding (PTB) domains, which are both structural and functional modules facilitating substrate recognition by protein kinases, phosphatases or adapter molecules involved in signal transduction.
Autopublicação: o autor como editor no novo mundo editorial
Authors: Morgado Marta
Published: February 2022

A autopublicação tem uma má reputação no mundo literário e editorial, mas tem crescido cada vez mais durante a era da Internet. Desde a invenção da imprensa que a edição de autor se desenvolveu, mudando a forma como vemos um autor e um editor. As responsabilidades e tarefas de ambos começaram a fundir-se. Este artigo explica o que é a autopublicação e os vários tipos que existem; o porquê dos autores recorrerem a ela;  finalizando com os papéis que o autor começou a ter.
Procesamiento de big data utilizando el software HADOOP
Authors: Valdez Menchaca Alicia Guadalupe , Castañeda Alvarado Sergio Raúl , Zárate Martínez Ángel , Paiz Rivera Ana Lourdes Saray
Published: February 2022

Una de las tecnologías que integran la Industria 4.0, habilitadoras de la sociedad del conocimiento, es la tecnología big data; enfocada en el procesamiento distribuido de grandes volúmenes de datos generados a partir de transacciones diarias en las empresas y organizaciones, así como una variedad y velocidad del manejo de la información. En este proyecto de investigación se ha analizado el procedimiento para manejo de big data con el software de fuente abierta Apache Hadoop, creando una hoja de ruta para la instalación y configuración del software corriendo en una máquina virtual de Linux, como una primera parte de una estrategia tecnológica para el manejo de big data, esto con el fin de proporcionarles a las empresas una herramienta que apoye la toma de decisiones mediante el análisis de grandes volúmenes de datos.
educación en geociencias como eje de formación ciudadana en el contexto ecuatoriano
Authors: Peña Arcos Diego Andrés , Arias Ruiz Camilo
Published: February 2022

Las Geociencias abarcan el conjunto de disciplinas científicas que construyen conocimientos sobre el planeta. Dadas sus características y objetos de estudio, es importante reflexionar acerca de sus contenidos para la educación básica en el contexto ecuatoriano, teniendo en cuenta que esta se basa en tres objetivos: la formación de conocimientos y competencias académicas, el desarrollo de habilidades para la vida laboral, y la formación integral ciudadana. A partir de esta formación, científica y ciudadana, los estudiantes deberán ser capaces de asumir responsabilidades ciudadanas y ser conscientes del impacto de sus acciones en el entorno, así como servir como fiscalizadores y generadores de proyectos relacionados con las problemáticas ambientales derivadas de intervenciones humanas en la naturaleza. En el presente trabajo, se analizó el currículo de los niveles de educación obligatoria del área de Ciencias Naturales para Educación General Básica (EGB) y Bachillerato General Unificado (BGU), de forma que se puedan relacionar los contenidos de Geociencias con la perspectiva de formación ciudadana. Finalmente se llega a algunas conclusiones a partir de las reflexiones iniciales, y se hacen algunas propuestas de modificación y consolidación de conocimientos en Geociencias que formen una consciencia ciudadana integral e interesada por la sociedad y su entorno medio ambiental.
las puertas de un nuevo código de familia: directrices para la reforma del régimen económico del matrimonio en Cuba
Authors: Torga Hernández Nileidys
Published: February 2022

El régimen económico del matrimonio disciplina las relaciones patrimoniales de los esposos entre si y de estos con terceros. El Código de Familia cubano regula la comunidad matrimonial de bienes cómo régimen matrimonial pecuniario único, legal y obligatorio. Al promulgarse el actual Código, este fue uno de los logros de ese cuerpo normativo; pero hoy su conveniencia es cuestionada. La amplia protección del Derecho Internacional a la familia y las concepciones que promueve la Constitución cubana de 2019, sugieren la implementación de un régimen convencional del matrimonio en Cuba. Según la Disposición Transitoria Decimoprimera de la Constitución y el cronograma legislativo aprobado por la Asamblea Nacional del Poder Popular en diciembre de 2019; en marzo de 2021 debe comenzar el proceso de consulta y referendo de un nuevo Código de Familia. En este contexto, el siguiente material persigue como objetivo: delinear las directrices que marcan los Tratados Internacionales y la Constitución cubana de 2019, para fundamentar la modificación del régimen económico del matrimonio en Cuba. Mediante la utilización de los métodos teórico jurídico, histórico jurídico y de comparación jurídica se sistematizan los postulados que apuntan hacia la admisión de la autonomía de la voluntad de los cónyuges en su disposición.
Repensando el concepto de arte a través del turismo: el turismo de arte callejero en Guayaquil
Authors: Pacherres Nolivos Sofía Lissette , Vergara Romero Arnaldo Andrés , Sorhegui Rodríguez Rafael
Published: February 2022

El movimiento de arte comunitario avanza con fuerza mediante los sinónimos de arte callejero, graffiti, pos-graffiti, arte urbano o art-like. La relación del arte callejero y el turismo se ve ligado desde las formas conceptuales hasta los turistas que se unen a la transmisión de percepciones históricas, demandas populares o alegrías colectivas. El propósito de este artículo es aclarar qué tipo de influencia tiene el turismo en el arte en le comunidad local desde la perspectiva de sociedad turística, utilizando el caso del turismo artístico en Guayaquil, Guayas-Ecuador. La generación y el consumo del arte callejero en Guayaquil está impulsado no sólo por la lógica de la estética, sino para la lógica del turismo. A partir de aquí, queda claro que el surgimiento de “art-like” no implica críticas en el campo del turismo, sino que está sacudiendo el concepto de arte que se ha asumido en la investigación convencional.
Factores que inciden en la corrupción de funcionarios en el Perú
Authors: Zorrilla Claudio Meza , Carhuancho Mendoza Irma Milagros
Published: February 2022

La corrupción es un flagelo que afecta los derechos de las personas en relación a la calidad de vida y el desarrollo de la sociedad, en vista que cada vez se sienten oprimidos y relegados. El objetivo fue analizar los factores que inciden en la corrupción de funcionarios en el Perú. El paradigma utilizado fue el interpretativo, de enfoque cualitativo, método inductivo, analítico y estudio de caso. De esta forma, se aplicó la guía de entrevista con la técnica de la entrevista, las unidades informantes fueron exfuncionarios públicos. Teniendo como resultado que los factores: cultural, valores, deontología y social sí inciden en la corrupción de funcionarios, recalcando que carecen de valores éticos, morales y del bien común, la sociedad actual los corrompe. En este contexto el Estado tiene que implementar políticas para una adecuada enseñanza de los valores y principios éticos, uno de los factores de mayor incidencia es el entorno social.
Особенности распространения и поглощения электромагнитных сигналов в периодических структурах из проводящих и диэлектрических слоев
Authors: Богацкая А.В. , Кленов Н.В. , Никифорова П.М. , Попов А.М. , Щеголев А.Е.
Published: February 2022

Different regimes of electromagnetic signal transmission through heterostructures formed by a sequence of conducting and non-conducting layers are discussed for various ratios between the frequency of radiation and the transport frequency of electron scattering in the conducting layers. Possibility to increase the efficiency of detecting or filtering electromagnetic radiation in a wide range of frequency range (from subTHz to far IR) in such structures is analyzed.
Измерение шумов интенсивности и стабильности частоты повторения импульсов Сr:ZnSe-лазера с пассивной синхронизацией мод
Authors: Леонов С.О. , Фролов М.П. , Коростелин Ю.В. , Скасырский Я.К. , Федоров П.Ю. , Шелковников А.С. , Козловский В.И. , Киреев А.Н. , Губин М.А.
Published: February 2022

The results on intensity noise and repetition frequency stability measurements for a passive mode-locked Cr:ZnSe laser pumped by a thulium-doped fiber laser at a wavelength of 1.94 µm are presented. The stability parameters and intensity noise are compared for three different generation regimes of the Cr:ZnSe laser. The laser operated at a repetition rate of 129.5 MHz and a central wavelength of 2.45 µm.
Сверхкритический резонанс в присутствии сильного магнитного поля
Authors: Тумаков Д.А. , Мальцев И.А. , Попов Р.В. , Шабаев В.М.
Published: February 2022

Рассчитаны положение и ширина сверхкритического резонанса, образующегося при погружении основного состояния одноэлектронного иона в отрицательно-энергетический континуум в присутствии сильного магнитного поля. Исследовано влияние величины магнитного поля на параметры резонанса. Ключевые слова: сверхкритическое поле, комплексное вращение.
Динамика наведенного поглощения и нелинейно-оптический отклик в коллоидных квантовых точках Ag-=SUB=-2-=/SUB=-S
Authors: Смирнов М.С. , Овчинников О.В. , Звягин А.И. , Тихомиров С.А. , Понявина А.Н. , Поведайло В.А. , Тхань Бинь Нгуен , Хонг Минь Фам
Published: February 2022

The mechanism of formation of the nonlinear optical response of colloidal solutions of Ag2S quantum dots passivated with thioglycolic acid molecules is considered. Using the Z-scan method for 10 ns pulses of the second harmonic of a YAG:Nd laser, the appearance of nonlinear absorption and nonlinear refraction is shown. A saturating dependence of the absorption coefficient with an increase in the intensity of the incident radiation is found. An assumption was made about the participation in the process of nonlinear absorption of localized states of levels of Ag2S structural defects, including the defect luminescence center, which was confirmed by femtosecond induced absorption spectroscopy. The formation of a broad structureless induced absorption band in the 500–1000 nm region is shown, which decays on a time scale of hundreds of picoseconds. It is concluded that the induced absorption signal is determined by the fast (within fractions of picoseconds) process of charge carrier capture by localized states, which subsequently determine the nonlinear absorption of 10 ns pulses.
Using Virtual Reality to Induce and Assess Objective Correlates of Nicotine Craving: Paradigm Development Study (Preprint)
Authors: Liu Weichen , Andrade Gianna , Schulze Jurgen , Doran Neal , Courtney Kelly E
Published: February 2022

BACKGROUND

Craving is a clinically important phenotype for the development and maintenance of nicotine addiction. Virtual reality (VR) paradigms are successful in eliciting cue-induced subjective craving and may even elicit stronger craving than traditional picture-cue methods. However, few studies have leveraged the advances of this technology to improve the assessment of craving.

OBJECTIVE

This report details the development of a novel, translatable VR paradigm designed to both elicit nicotine craving and assess multiple eye-related characteristics as potential objective correlates of craving.

METHODS

A VR paradigm was developed, which includes three Active scenes with nicotine and tobacco product (NTP) cues present, and three Neutral scenes devoid of NTP cues. A pilot sample (N=31) of NTP users underwent the paradigm and completed subjective measures of nicotine craving, sense of presence in the VR paradigm, and VR-related sickness. Eye-gaze fixation time (“attentional bias”) and pupil diameter toward Active versus Neutral cues, as well as spontaneous blink rate during the Active and Neutral scenes, were recorded.

RESULTS

The NTP Cue VR paradigm was found to elicit a moderate sense of presence (mean Igroup Presence Questionnaire score 60.05, SD 9.66) and low VR-related sickness (mean Virtual Reality Sickness Questionnaire score 16.25, SD 13.94). Scene-specific effects on attentional bias and pupil diameter were observed, with two of the three Active scenes eliciting greater NTP versus control cue attentional bias and pupil diameter (Cohen d=0.30-0.92). The spontaneous blink rate metrics did not differ across Active and Neutral scenes.

CONCLUSIONS

This report outlines the development of the NTP Cue VR paradigm. Our results support the potential of this paradigm as an effective laboratory-based cue-exposure task and provide early evidence of the utility of attentional bias and pupillometry, as measured during VR, as useful markers for nicotine addiction.
Health Professionals’ Sentiments Towards Implemented Health Information Technologies in Psychiatric Hospitals: A Text-Mining Analysis (Preprint)
Authors: Golz Christoph , Aarts Sil , Hacking Coen , Hahn Sabine , Zwakhalen Sandra M.G.
Published: February 2022

BACKGROUND

Psychiatric hospitals are increasingly being digitalised. Digitalisation often requires changes at work for health professionals. A positive attitude from health professionals towards technology is crucial for a successful and sustainable digital transformation at work. Nevertheless, insufficient attention is being paid to the health professionals’ sentiments towards technology.

OBJECTIVE

This study aims to identify the implemented technologies in psychiatric hospitals and to describe the health professionals’ sentiments towards these implemented technologies.

METHODS

A text-mining analysis of semi-structured interviews with nurses, physicians and psychologists was conducted. The analysis comprised word frequencies and sentiment analyses. For the sentiment analyses, the SentimentWortschatz dataset was used. The sentiments ranged from -1 (strongly negative sentiment) to 1 (strongly positive sentiment).

RESULTS

In total, 20 nurses (n = 11), physicians (n = 5) and psychologists (n = 4) participated in the study. When asked about the technologies they used, the participating health professionals mainly referred to the computer, email, phone and electronic health record. Overall, 4% of the words in the transcripts were positive or negative sentiments. Of all words that express a sentiment, 73% were positive. The discussed technologies were associated with positive and negative sentiments. However, of all sentences that described technology at the workplace, 69.4% were negative.

CONCLUSIONS

The participating health professionals mentioned a limited number of technologies at work. The sentiments towards technologies were mostly negative. The way in which technologies are implemented and the lack of health professionals’ involvement seem to be reasons for the negative sentiments.
A Digital Intervention Using Daily Financial Incentives to Increase Medication Adherence in Severe Mental Illness: A Feasibility Study (Preprint)
Authors: Guinart Daniel , Sobolev Michael , Patil Bhagyashree , Walsh Megan , Kane John M.
Published: February 2022

BACKGROUND

Medication non-adherence is prevalent in severe mental illness and is associated with multiple negative outcomes. Mobile technology and financial incentives show promise to improve medication adherence, but studies in mental health, especially with oral medications, are lacking.

OBJECTIVE

Assess the feasibility and effectiveness of offering financial incentives through a mobile app based on behavioral economics principles to improve medication adherence in severe mental illness.

METHODS

A 10-week, single-arm longitudinal pilot study was conducted (NCT04191876). Patients earned rewards in the context of app-based adherence incentives. The reward was split into bi-weekly payments made in increments of $15, minus any $2/day penalties for missed check-ins. Time-varying effect modeling (TVEM) was used to summarize patient’s response during the study.

RESULTS

Twenty-five patients were enrolled in this pilot study, 72% (n=18) of them female, and 48% (n=12) white. Median age was 24 years (Q1-Q3: 20.5-30). Participants were more frequently diagnosed with schizophrenia and related disorders (n=9, 36%), followed by major depressive disorder (n=8, 32%). App engagement and medication adherence in the first two weeks were higher than in the last eight weeks of the study. At study endpoint, app engagement remained high (N=24, Z=-3.17, p=.000) but medication adherence was not different from baseline (N=24, Z=-.59, p=.28).

CONCLUSIONS

Financial incentives were effectively delivered using an app and led to high engagement throughout the study and to significantly increased medication adherence during two-weeks. Leveraging behavioral economics and mobile health technology can increase medication adherence.

CLINICALTRIAL

NCT04191876
Behind the Mask of Virtue: CSR Indocement's Original Face in the Conflict of Cement Factory Construction in Pati
Authors: Novianto Arif , Effendi Kurnia Cahyaningrum , Purbokusumo Yuyun
Published: February 2022

Discourses about Corporate Social Responsibility (CSR) are generally understood as goodwill and social virtue. This research with a CSR Indocement case study in the Pati District found something different in the study in areas that have not been affected by and in the process of expansion from PT SMS (a subsidiary of PT Indocement Tunggal Prakarsa). CSR Indocement, which has been run in Pati since 2012, is not based on a business ethic or corporate social virtue model. With political economy analysis, we found that 1) CSR Indocement runs in Pati as an effort to expedite the expansion of their capital which has strong resistance from the community rejecting the cement factory; 2) CSR Indocement for the last five years in Pati, nearly 90 programs that have been attempted none have been able to empower the community. These efforts were influenced by two things: 1) In carrying out its program CSR Indocement brought the program to the village elites.  2) CSR Indocement's initial goal for Pati was to build a consensus to give a red carpet for capital expansion so that the goal of empowerment is not paramount.
Biological Synthesis of Metallic Nanoparticles and their Applications
Authors: Kalidas Gowtham , Pranav Rithish Jayakumar
Published: February 2022

Abstract: Nanoparticles have a wide range of applications in our day to day life. Different methods of biological synthesis of metallic nanoparticles are being employed worldwide and many researches are still underway as a part of improvement strategy. Various microorganisms and abundant plant materials are used for this purpose. A chemical reducing agent is often replaced by the extracts of plants and microorganisms during the biosynthesis phenomena of nanoparticles which have proven to be novel approach in recent years. Biosynthesis of some important metallic nanoparticles and their applications is the main objective of the study. Keywords: Nanoparticles, Biosynthesis, Reducing agent, Plants, Microorganisms and Metallic Nanoparticles