bluuebunny/crossref_metadata_2025 huggingface dataset:
Mutational Signatures in Salivary Gland Carcinomas
Authors: CHRYSOVERGIS ARISTEIDIS , PAPANIKOLAOU VASILEIOS , SPYROPOULOU DESPOINA , ROUKAS DIMITRIOS , ASIMAKOPOULOS ASIMAKIS D. , PAPANASTASIOU GEORGE , MASTRONIKOLI SOFIANIKI , FALIDAS EVANGELOS , PAPOULIAKOS SOTIRIOS , TSIAMBAS EVANGELOS , PANTOS PAVLOS , RAGOS VASILEIOS , PESCHOS DIMITRIOS , MASTRONIKOLIS NICHOLAS , KYRODIMOS EFTHYMIOS
Published: July 2023

Salivary gland carcinomas belong to the head and neck carcinoma super category of malignancies. They are characterized by histopathological diversity and comprise a variety of entities and subtypes. Mucoepidermoid, adenoid cystic and salivary duct carcinomas represent the most prominent malignancies. Concerning their corresponding genetic background, a broad spectrum of gene and chromosomal imbalances has been detected. Point mutations and deletions, amplifications and translocations, combined or not with chromosomal aneuploidy/polysomy/monosomy, create a landscape of specific genetic signatures that affect the biological behavior of these tumors and modify response rates to potential targeted therapeutic strategies. In the current molecular review, we focused on the categorization and description of the most important mutational signatures in salivary gland carcinomas.
Spinal Instability as a Prognostic Factor in Patients With Spinal Metastasis of Castration-resistant Prostate Cancer
Authors: MIYAJI YOSHIYUKI , NAKANISHI KAZUO , YAMAMOTO AKIRA , YODEN EISAKU , TOKIYA RYUJI , OKAWAKI MAKOTO , INUBUSHI MASAYUKI , KATSUI KUNIAKI
Published: July 2023

Background/Aim: To evaluate the Spinal Instability Neoplastic Score (SINS) for prediction of survival in patients with spinal column metastasis of castration-resistant prostate cancer (CRPC). Patients and Methods: A retrospective study of spinal instability was performed in patients with CRPC using SINS. Overall survival was evaluated starting from the time of SINS evaluation. The subjects were 42 patients with CRPC among 261 cases diagnosed with metastatic spinal tumors by radiologists, among 42,152 cases that underwent a body computed tomography scan at Kawasaki Medical School Hospital within 32 months from December 2013 to July 2016. Results: The median age was 78 (range=55-91 years), the median prostate-specific antigen (PSA) level at SINS evaluation was 42.1 (0.1-3,121.6) ng/ml, and 11 patients had visceral metastasis. The median periods from diagnosis of bone metastasis and development of CRPC to SINS evaluation were 17 (0-158) and 20 (0-149) months, respectively. The spine was stable in 32 cases (group S) and potentially unstable or unstable in 10 (24%) (group U). The median observation period was 17.5 (0-83) months and 36 patients died. The median survival period after SINS evaluation was longer in group S than that in group U (20 vs. 10 months, p=0.0221). In multivariate analysis, PSA level, visceral metastasis, and spinal instability were significant prognostic factors. The hazard ratio for patients in group U was 2.60 (95%CI=1.07-5.93, p=0.0345). Conclusion: Spinal stability evaluated using SINS is a new prognostic factor for survival of patients with spinal metastasis of CRPC.
WPOI-4/5 Correlates With Lymph Node Recurrence and Poor Prognosis in Early-stage Tongue Squamous Cell Carcinoma
Authors: YAMAUCHI MORIYASU , ISHIDA TOMOYA , MINESAKI AKIMICHI , KURATOMI YUICHIRO
Published: July 2023

Background/Aim: Neck management in patients with early-stage tongue cancer remains controversial. The worst pattern of invasion (WPOI) of the primary tumor has been associated with the incidence of regional metastasis. We investigated the prognostic role of WPOI, especially in relation to regional lymph node recurrence and disease-specific survival (DSS). Patients and Methods: We retrospectively reviewed medical records and evaluated tumor specimens of 38 patients with early-stage tongue cancer who underwent primary tumor resection without elective neck dissection. Results: Regional lymph node recurrence rates were significantly higher in patients with WPOI-4/5 compared with WPOI-1 to -3. The 5-year DSS rates were significantly higher for WPOI-1 to -3 than for WPOI-4/5. Notably, patients with WPOI-1 to -3 achieved a 100% 5-year DSS rate with salvage neck dissection and postoperative treatment, even those with cervical lymph node recurrence, whereas patients with WPOI-4/5 had a poorer prognosis. Conclusion: Patients with WPOI-1 to -3 tumors can be followed up without neck dissection until regional lymph node recurrence is detected, with a good course after salvage treatment. In contrast, patients with WPOI-4/5 tumors who are followed up until the appearance of regional lymph node recurrence have a poor prognosis, even with adequate treatment for recurrent disease.
A Prospective Study of Intensity-modulated Radiation Therapy Using a Standard Radiation Dose for High-grade Glioma
Authors: TAKAHASHI SHIGEO , MIYAKE KEISUKE , OGAWA DAISUKE , ANADA MASAHIDE , KINOSHITA TOSHIFUMI , NISHIDE TAKAMASA , SHIBATA TORU
Published: July 2023

Background/Aim: We evaluated the treatment outcomes of intensity-modulated radiation therapy (IMRT) using a standard radiation dose in patients with high-grade glioma (HGG). Patients and Methods: We conducted a prospective, single-institutional, single-arm trial. Patients aged 20-75 years with histologically proven HGG were enrolled. Surgical procedures and chemotherapy regimens were not regulated. The prescribed dose of postoperative IMRT was 60 Gy in 30 fractions over six weeks. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS), completion rate of IMRT, and Grade 3 or higher non-hematological toxicity. Results: Between 2016 and 2019, 20 patients were enrolled. According to the World Health Organization 2016 Classification, glioblastoma, anaplastic astrocytoma, and anaplastic oligodendroglioma were present in nine, six, and five of the recruited patients, respectively. Gross total resection, partial resection, and biopsy were performed in four, nine, and seven patients, respectively. All patients received concurrent and adjuvant chemotherapy using temozolomide with or without bevacizumab. The completion rate of IMRT was 100%. The median follow-up period was 29 months (range=6-68 months). Median OS and PFS were 30 and 14 months, respectively. No patients experienced Grade 3 or higher non-hematological toxicity. The 2-year OS rates were 100%, 57%, and 33% in Radiation Therapy Oncology Group-Recursive Partitioning Analysis (RTOG-RPA) classes I/II, IV, and V, respectively (p=0.002; log-rank test). Conclusion: IMRT using the standard radiation dose in patients with HGG can be carried out safely. RTOG-RPA class appears to be useful to estimate patient prognoses.
Hypothyroidism With ACTH Deficiency During Pembrolizumab Therapy for Lung Cancer: Case Report and Literature Review
Authors: HASHINOKUCHI ASATO , HARO AKIRA , MINAGAWA REIKO , HARUTA YASUHIRO , KAWANO HIROYUKI , SUEHIRO TAKETOSHI , SUGIMACHI KEIZO
Published: July 2023

Background/Aim: Immune-checkpoint inhibitors have recently shown great promise in treating various cancers, but often cause immune-related adverse events (irAEs). Simultaneous drug-induced hypothyroidism and isolated adrenocorticotropic hormone (ACTH) deficiency are rare irAEs. This combination of irAEs is associated with paradoxical endocrine dysfunction characterized by large amounts of thyroid-stimulating hormone (TSH) and small amounts of ACTH in the anterior lobe of the pituitary. We herein report a case of hypothyroidism with isolated ACTH deficiency during pembrolizumab therapy for recurrent lung cancer. Case Report: Our patient was a 66-year-old man with recurrence of squamous cell lung carcinoma. Four months after chemotherapy that included pembrolizumab, the patient presented with general fatigue and laboratory tests showed high concentrations of TSH with low concentrations of free-T4. He was diagnosed with hypothyroidism and levothyroxine was prescribed. His ACTH concentration was found to be low 1 week later when he developed an acute adrenal crisis with associated hyponatraemia. We then changed his diagnosis to concurrent hypothyroidism with isolated ACTH deficiency. His condition improved after 3 weeks of administration of cortisol. Conclusion: It is difficult to diagnose a concurrent paradoxical endocrine disorder, such as hypothyroidism with isolated ACTH deficiency, as in the present case. Physicians should pay attention to symptoms and laboratory data to identify various types of endocrine disorders as irAEs.
Evaluación del estilo de vida con el riesgo de diabetes mellitus tipo 2 en trabajadores universitarios ecuatorianos
Authors: Suárez Rosario , Diaz Patricia , Sarmiento-Andrade Yoredy , Cadena Marcela , Alvarez Ludwig , Frias-Toral Evelyn
Published: July 2023

Algunos trabajadores mantienen estilos de vida no saludables que los hace propensos a tener un alto riesgo de diabetes tipo 2 (DT2). El presente estudio tuvo como objetivo evaluar el riesgo de DT2 (RDT2) en personal administrativo y docente de una universidad ecuatoriana y factores asociados. Estudio de corte transversal que evaluó el RDT2 según FINDRISC. Se consideró RDT2 alto si la puntuación ≥12 puntos. Se analizaron aspectos sociodemográficos, hábitos nocivos y saludables; se midieron el índice de masa corporal (IMC), el perímetro abdominal (PA) y la tensión arterial (TA). Se evaluaron las razones de prevalencia bruta (RPB) y ajustada (RPA) para identificar factores asociados con RDT2. De 311 participantes, edad media de 41,02 años (DE 10,1), 58,2% mujeres y 41,8% hombres. La prevalencia de RDT2 elevada fue mayor en mujeres respecto a varones (38,1% frente a 32,3%) y aumentó en mayores de 40 años [RPA 1.55 (1.11-2.15)], personas casadas [RPA 1.49 (1.07-2.05)], aquellos con actividad física moderada o menor [RPA 1.55 (1.11-2.15)], y en aquellos con PA elevado [RPA 2,41 (1,33 - 4,36)]. La edad, la baja actividad física y el PA, fueron factores asociados con una mayor prevalencia de RDT2. Se deben promover estilos de vida saludables, para incrementar la actividad física y disminuir el PA en trabajadores, para reducir el riesgo de DT2.

Palabras claves: Diabetes Mellitus tipo 2, Estilos de Vida, Factores de Riesgo, Salud Laboral
Spatiotemporal analysis of regional and age differences in tuberculosis prevalence in mainland China before the COVID-19 pandemic outbreak (Preprint)
Authors: Fengwen Huang
Published: July 2023

UNSTRUCTURED

Abstract
Background: Globally, tuberculosis (TB) is a leading cause of death by an infectious disease. China ranks third among the 30 high-burden countries for TB and accounts for approximately 7.4% of the cases reported worldwide. It was necessary to promulgate more constructive measures in keeping with the times.
Methods: The data of reported sputum smear-positive (SS+), TB and sputum smear-negative (SS-) cases in 340 prefectures from mainland China were extracted from the China Information System for Disease Control and Prevention (CISDCP) from January 2009 to December 2018. Multiple statistical analysis and GIS techniques were used to investigate the temporal trend and identify the spatial distribution of SS+, TB and SS- cases in the study area. Age differences in TB prevalence of these three cases were also examined at the prefecture level.
Results: The results showed that the incidence of SS+ and TB has dropped to a stable level, while SS- exhibited a rising trend. Additionally, it is worth noting that the mortality of these three subjects exhibited an increasing trend since 2014, which might be caused by the potential Mycobacterium tuberculosis. Nevertheless, SS+, TB and SS- are still highly prevalent in northwestern and southwestern regions of China. Finally, the young adult group (20-50 age) and elder group (> 50 age) are susceptible to being infected with TB, while lower infection levels in the juvenile group (< 20 age).
Conclusions: The present study investigated the temporal-spatial distribution of SS+, TB and SS- cases in mainland China before the COVID-19 pandemic breakout, which would help the government agency establish an effective mechanism of TB prevention in high-risk periods and high-risk areas in the study region.
Effect of Teaching Sequence on ESL Students’ Learning of Syntactic Cohesive Devices Using Sentence Transformation
Authors: Siu Fiona K. P.
Published: July 2023

This research aims to investigate the effects of two teaching sequences – interleaving and blocking – on the participants’ use of three types of cohesive devices (conjunctions, conjunctive adverbs and prepositions [thereafter CCPs]) in their argumentative essays. The participants included 50 native Cantonese-speaking university students taking an academic writing course. Interleaving refers to the teaching sequence in which learners practice several skills at one time whereas in blocking only one skill is practiced at one time.Prior to essay writing, participants were taught CCPs using sentence transformation. One class was taught using interleaving and the other blocking. The first and the second drafts of the argumentative essay served as pre-and post-tests. The total numbers of CCPs used correctly both syntactically and semantically in their argumentative essays were counted for the pre-tests and post-tests for both groups. Results of Paired Samples and Independent t-tests suggest that neither of the two teaching sequences was more effective than the other in raising the participants’ total instances of CCPs; however, blocking appears to be more effective in boosting the use of prepositions as linking words. Sentence transformation, whether administered in the interleaved or blocked sequence, was considered to have served the teaching purpose of providing an opportunity for the students to engage in serious thinking about the semantic relationship between two given sentences.
ANTIOXIDANT, ANTICANCER AND MOLECULAR DOCKING STUDIESOF NOVEL 5-BENZYLIDENE SUBSTITUTED RHODANINE DERIVATIVES
Authors: MATHEW CICI , LAL NAND , S. LAKSHMI , T. R. ASWATHY , VARKEY JOYAMMA
Published: July 2023

Objective: The primary objective was to study the in vitro antioxidant and anticancer evaluation of novel 5-benzylidene substituted rhodanine derivatives and molecular docking studies of the most active compounds with 3 different anticancer targets.
Methods: Antioxidant potential of 5-benzylidene substituted rhodanine derivatives were studied by DPPH assay, anticancer evaluation was done by MTT assay and Computational evaluation were done using various softwares such as ACD Lab Chemsketch 12.0, molinspiration and Discovery Studio 2021.
Results: Compound 3j exhibited the highest antioxidant activity with an IC50 value of 31.21. Other compounds 3b, 3d and 3f also showed moderate antioxidant potential. The Antioxidant study showed a good correlation with molecular docking studies. In vitro anticancer assay results showed that compound 3a has an IC50 value<62.5 against HeLa cell lines. All the other compounds showed only moderate activity. Out of the ten synthesized derivatives, compounds 3d and 3j showed good docking scores with 3 different anticancer targets.
Conclusion: Ten novel rhodanine derivatives which has been studied can be developed into potent antioxidant and anticancer agents in future.
EFFECT OF COOKING METHODS ON TOTAL PHENOLICS AND ANTIOXIDANT ACTIVITY OF SELECTED WILD EDIBLE PLANTS
Authors: SEAL TAPAN , PILLAI BASUNDHARA , CHAUDHURI KAUSIK
Published: July 2023

Objective: The target of this appraisal was to explore the impacts of various cooking techniques, for example, boiling and microwave cooking on total phenolics and antioxidant activity of Zanthoxylum acanthopodium, Viburnum foetidum, Houttuynia cordata, Sonchus arvensis and Oenanthe linearis, widely consumed by the common individuals of the North-Eastern area of India.
Methods: The antioxidant activities of the plants were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content and flavonol content.
Results: Total phenolics content (TPC) of fresh vegetables ranged from 108.28 to 253.99 mg/100 g (as gallic acid equivalent) on a dry weight basis. Total antioxidant capacity of fresh plants (IC50 mg dry extract) determined by DPPH and ABTS ranged from 0.37-1.23 and 0.29-0.89, respectively. Boiling caused the highest losses of TPC, resulting in a reduction of the TPC on dry weight (DW) basis ranging from 9.37% in O. linearis up to 25.97% in Z. acanthopodium whereas microwave cooking enhanced TPC ranging from 4.09% to 10.38%. Similarly, boiling treatment decreased the DPPH radical scavenging activities ranging from 10.65 to 29.77% and ABTS radical scavenging activities ranging from 5.88-16.35%, whereas microwave cooking increased the DPPH and ABTS radical scavenging activities ranging from 8.02-24.20% and 9.86 to 19.70% respectively, in the studied plants.
Conclusion: The results suggest that the best cooking method for increasing the concentration of polyphenols and antioxidants was microwave cooking while boiling was the least recommended method.
As interfaces da língua em uso. Um tratamento funcionalista da entidade “oração”
Authors: Neves Maria Helena De Moura
Published: July 2023

O objetivo do estudo é, com apoio na teoria funcionalista da linguagem, problematizar as interfaces da língua em uso, pondo centro especial na gramática que rege a língua e considerando todo o entorno da produção da linguagem. Em busca de paralelos com o próprio texto, parte-se da entidade “oração”, que é problematizada como organização da informação, como organização da interação linguística e como organização semântica. Entra em questão todo o processamento de configuração das cadeias linguísticas que se produzam, considerada a interface com o próprio fazer da linguagem, expandido na vivência em comunidade de língua. No exame fica evidente que, para o resultado semântico e para o efeito pragmático pretendidos, releva a existência de uma determinação pragmática sobre o arranjo sintático. A conclusão é que a consciência dessa integração que aciona a gramática, levando à produção linguística, é o que permite a separação analítica dos processos, garantindo análises teoricamente sustentadas.
Constituintes extraoracionais e sua ordenação linear
Authors: Camacho Roberto Gomes , Pezatti Erotilde Goreti
Published: July 2023

O objetivo geral deste artigo é fazer uma descrição de Constituintes Extraoracionais (ECCs) no português, adotando a posição de Giomi e Keizer (2020) de que esses constituintes, que sinalizam determinadas funções retóricas na superfície textual, não podem ser deixados no limbo por uma teoria voltada para o princípio de adequação pragmática como a Gramática Discursivo-Funcional (GDF). O propósito específico deste estudo é mostrar, por um lado, o caráter sintaticamente frouxo desses constituintes, que podem aparecer em posições especiais, repetidas ou não, na estrutura da Expressão Linguística, e, por outro, a proximidade teórica entre a Teoria da Estrutura Retórica (RST) (MANN; THOMPSON, 1988; MANN et al., 1992; TABOADA; MANN, 2006) e a GDF (HENGEVELD; MACKENZIE, 2008), em termos da função retórica que os ECCs exercem. A análise mostrou que, para a GDF e a RST, os ECCs nunca fazem parte do Ato Discursivo Nuclear e, portanto, sua posição dentro da Expressão Linguística, na perspectiva da GDF, não pode ser determinada por diferenças de escopo funcional, seja interpessoal seja representacional. Como uma consequência teórica importante, o fato de uma ordenação hierarquicamente orientada ser irrelevante para a sintaxe extraoracional explica por que não é possível identificar qualquer posição absoluta ou relativa na camada da Expressão Linguística para abrigar os ECCs.
Construções contrastivas com enquanto que e sendo que
Authors: Dias Nilza Barrozo
Published: July 2023

Os objetivos deste trabalho são verificar quais relações semânticas identificadas por Neves (2000) para a conjunção mas podem ser encontradas nas construções em estudo, no século XXI; e quais relações semânticas das construções com enquanto que e sendo que, identificadas no século XXI, são recorrentes nos séculos XVI-XX. Utilizo os pressupostos da Linguística Baseada no Uso, propostos por Bybee (2016) e Diessel (2017), que usam bases teóricas do Funcionalismo e da Linguística Cognitiva. Apresenta-se um esquema muito amplo [X- QUE conector], sendo o X representado na fonte, pela conjunção adverbial enquanto e pelo elemento verbal sendo, que apontam, respectivamente, tempo simultâneo e em curso, formando junto com o que um chunk de valor contrastivo. Considera-se como hipótese que a motivação de o falante migrar elementos linguísticos de base temporal para a categoria de conectores contrastivos se assenta no tempo simultâneo e em curso, que proveem material para o contraste. A primeira construção instancia preferencialmente um contraste simples que se assenta na comparação de eventos, de indivíduos, de resultados estatísticos, de itens lexicais, enquanto a segunda construção é mais usada para fazer a relação semântica de parcialidade em relação ao primeiro segmento e de gradação em relação ao primeiro segmento ou à porção maior de informação. Os novos conectores fazem uma extensão da rede contrastiva.
Impact of Generative AI on IT Professionals
Authors: Nhavkar Varun Kisan
Published: July 2023

Abstract: This research paper aims to explore the impact of generative artificial intelligence (AI) on IT professionals. Generative AI refers to the technology that can autonomously create new content, such as images, text, and even code. With the rapid advancements in AI, the role of IT professionals is evolving, and it is crucial to understand the implications of generative AI on their work. This paper examines the potential benefits, challenges, and ethical considerations associated with the integration of generative AI in the IT industry. Through a comprehensive analysis of existing literature, this paper sheds light on the transformation of IT professionals' responsibilities, skills, and career prospects in the era of generative AI.
Superworm (Zophobas morio) breeding for papaya stem waste management
Authors: Lisanty Nina , Hadiyanti Nugraheni , Wibowo Moch. Agus Suryo , Saputro Nanang Aji , Whintisna Nixie Azalia , Nurfitri Rafelda Dias
Published: July 2023

Boyolangu District is a famous papaya-producing area and the largest in Tulungagung Regency. The local papaya farming community is active in farming. They succeeded in producing approximately 10 tons of papaya in 2020. This number has decreased by more than half from the previous year in 2019. This is inseparable from the impact of the COVID-19 pandemic. In addition, the community complaint about a large amount of papaya stem waste after harvest. Waste management is a separate problem for farmers. Not to mention the added problem of the low price of papaya per kilogram. Therefore, a community service program aims to overcome the target community's problems with superworm (Zophobas morio) breeding education and training. The activity conducted by the team of the Faculty of Agriculture, University of Kadiri empowering the papaya farming community in Boyolangu District, Tulungagung Regency to manage papaya stem waste as an alternative feed for superworm breeding. Farmers were invited to breed superworm as their additional income and improve the standard of living of the family. This activity mainly focused on the introduction and training of superworm breeding. The activity was beneficial for the social, economic, and environmental life of the target community.
Öz-Konuşma Ve İmgelemenin Hentbol Atış Performansına Etkisi: Deneysel Bir Araştırma
Authors: ERGİN Rıdvan , GENCER Eylem
Published: July 2023

Araştırmanın amacı, öz-konuşma ve imgeleme antrenman deneyimi olmayan kadın hentbolcularda öz-konuşma ve imgeleme müdahalelerinin hentbol atış performansına etkisini incelemektir. Araştırma, nicel araştırma yöntemlerinden deneysel araştırma modeliyle gerçekleştirilmiştir. Deneysel modelde, aynı bireyler üzerinde farklı zaman dilimlerinde uygulanan iki farklı müdahalenin (öz-konuşma ve imgeleme) atış performansına etkisi incelendiği için araştırma deney grubu üzerinden gerçekleştirilmiştir. Araştırma grubunu, amaçsal örnekleme yöntemine göre belirlenen, 2022-2023 sezonu hentbol birinci liginde mücadele eden 14 kadın hentbolcu (yaş 20±2 yıl) oluşturmuştur. Araştırmada veriler, katılımcıların hentbol kalesinde önceden belirlenen hedeflere gerçekleştirdikleri atış performansları (isabetli/isabetsiz) aracılığıyla toplanmıştır. Araştırmada elde edilen verilerin analizinde betimsel (ortalama, standart sapma) ve çıkarımsal (Tekrarlı Ölçümler için Tek Faktörlü ANOVA) istatistiklerden yararlanılmıştır. Bulgular, kadın hentbolcuların müdahalesiz atış performansları ile öz-konuşma ve imgeleme müdahaleleri sonrasındaki atış performansları arasında istatistiksel olarak anlamlı bir farklılığın olmadığını göstermiştir. Sonuç olarak, öz-konuşma ve imgeleme antrenman deneyimi olmadan, atış performansı öncesinde başvurulan öz-konuşma ve imgelemenin kadın hentbolcuların atış performansı üzerinde anlamlı bir etkisinin olmadığı söylenebilir.
DİJİTAL OKURYAZARLIK VE DİJİTAL BAĞIMLILIK İLİŞKİSİ: HOKEY SPORCULARI ARAŞTIRMASI
Authors: ÖZSARI Arif , DELİ Şekip Can
Published: July 2023

Bu araştırma ile dijital okuryazarlık ve dijital bağımlılık ilişkisinin incelenmesi amaçlanmıştır. Araştırmanın çalışma grubunu 118 kadın, 82 erkek olmak üzere toplamda 200 aktif lisanslı hokey sporcusu oluşturmaktadır. Araştırma verilerinin toplanmasında Ng (2012) tarafından geliştirilen, Türkçe uyarlama çalışmaları ve dilsel eşdeğerliliği Hamutoğlu ve ark. (2017) tarafından yapılan dijital okuryazarlık ölçeği ile Arslan ve ark. (2015) tarafından geliştirilen dijital bağımlılık ölçeği ve kişisel bilgi formu kullanılmıştır. Betimleyici istatistiğin yanı sıra, Tukey testi ve One Way-Anova analizleri uygulanmıştır. İlişkisel model kapsamında ise korelâsyon ve regresyon analizlerine yer verilmiştir. Araştırma bulguları; hokey sporcularının dijital okuryazarlık düzeylerinin orta seviyede, dijital bağımlılık düzeylerinin ise düşük seviyede olduğu, dijital okuryazarlık ve dijital bağımlılık düzeylerinin cinsiyet ve sporculuk yılı değişkenlerine göre anlamlı bir şekilde farklılaştığı tespit edilmiştir. Dijital okuryazarlık ölçeğinin alt boyutu olan bilişsel ile dijital bağımlılık ölçeğinin alt boyutu olan sosyal medya bağımlılığı arasında pozitif yönlü ve zayıf düzeyli bir ilgileşim mevcuttur. Araştırma sonucu olarak; bu çalışma özelinde dijital okuryazarlığın dijital bağımlılık üzerinde anlamlı bir etkiye sahip olmadığı ifade edilebilir. Dijital bağımlılığın önlenmesi ya da azaltılması konusunda bireylerin, sportif faaliyetlere yönlendirilmesi önerilebilir.
ANALISIS FAKTOR PENENTU MINAT MASYARAKAT BERDONASI PADA GERAKAN INFAQ BERAS ACEH
Authors: Yasir Muhammad
Published: July 2023

This study aims to determine the effect of Religiosity, Income, and Situational Altruism simultaneously and partially on Community Interest in Donating at Gerakan Infaq Beras Aceh. Based on 100 questionnaires distributed to respondents, using the Probability Sampling method as measured by the Purposive Sampling technique and analyzed using multiple linear regression models, the results showed that together all the variables in this study had a positive and significant effect on Interest in Donating. Then partially the variables of Reliability, Income, and Situational Altruism have a positive and significant effect on Interest in Donating at Gerakan Infaq Beras Aceh. Promotional activities still really need to be improved considering that there are still many people who do not know about this philanthropy so that Gerakan Infaq Beras Aceh can become a great humanitarian platform and more and more people are interested in donating.
SYSTEM-FUNCTIONAL APPROACH TO UNDERSTANDING LEGAL TERMS
Authors:   Russian Presidential Academy of National Economy and Public Administration, Maron D.V.
Published: July 2023

The system-functional approach to understanding legal terms is considered. The author substantiates that terms can perform various functions, directly acting as a means of legal regulation of social relations. On this basis the conclusion about three understandings of terms is made.
PERSONNEL MOTIVATION IN TRANSNATIONAL IT CORPORATIONS
Authors:   People’s Friendship University of Russia, Zuenco Inna
Published: July 2023

The concepts of human resources, business management, and the motivation for managerial freedom are analyzed. Factors influencing labor productivity and employee motivation are revealed, based on the example of Google Corporation.
Kuttab in Indonesia: Its Existence and Development during the Reform Era
Authors: (Corresponding Author) Desti Widiani , Sirait Sangkot , Prastowo Andi , Munip Abdul
Published: July 2023

The re-emergence of the Kuttab is an interesting phenomenon to study in Indonesia. This institution continues to bloom after its last traces in 1952 in Riau. In 2012, the Kuttab Al-Fatih was established and developed in 23 cities. Other kuttabs began to emerge in different Indonesian regions. Therefore, this study attempts to show the existence and development of kuttab in the reform era in Indonesia. Data were collected using a Systematic Literature Review. The results showed that the re-emergence of post-reform kuttab caused a shock effect. This is because the curriculum developed was different from that of Islamic educational institutions. Furthermore, it is necessary to recognize government policy towards kuttab in Indonesia since it has no legal umbrella, hence, a solution is needed to seat this institution. First, the Ministry of Religion/Kemdikbudristek has to make regulations that contain kuttab nomenclature. Second, it is necessary to separate pesantren and kuttab. Third, the kuttab needs to be accommodated, fostered, adopted and supervised. Fourth, this institution is regarded as a formal pathway and is at the SD/MI level. The kuttab has two class systems including the initial I, II, III and the qanuni I, II, III, IV with ages 5-12 years. The kuttab diploma needs to be equivalent to a formal SD/MI education and not only PKBM, MSU, or Package A.
Significance of Islam Nusantara Values in an Indonesian Multicultural Society
Authors: (Corresponding Author) David Eko Setiawan , Stevanus Kalis
Published: July 2023

Indonesian society is plural, consisting of various cultures, religions, beliefs, and ethinicities. All these differences can trigger fanaticism, causing tension and conflict in society. This paper uses the literature method to describe the values contained in Islam Nusantara (Indonesian model of Islam). The results of the literature review show that Islam Nusantara values can act as an alternative and mediator when there is a conflict of differences, since it prioritize a high appreciation of plurality as a social reality. Islam Nusantara can drive social ethics to foster tolerance and social solidarity in a multicultural society like Indonesia.
Criticism of Social, Political, and Religious Problems in Indonesia: A Study on Al-Iklīl fī Ma‘ānī al-Tanzīl by Misbah Bin Zainil Mustafa (1917-1994)
Authors: Gusmian Islah , (Corresponding Author) Mustaffa Abdullah
Published: July 2023

Al-Iklīl fī Ma’ānī al-Tanzīl by Misbah bin Zainil Mustafa is a Qur’anic exegesis that was born from the pesantren tradition and was written during the New Order era under the leadership of President Soeharto. Through his exegesis, Misbah criticized social, political, and religious issues in Indonesia. The issues he highlighted, including how he formed his criticism, and its political as well as scholarly ramifications, are the focus of this study. Using descriptive, historical and explanatory methods, this article presents interesting and important findings. First, Misbah was an Indonesian ulama who started to publicly criticize the New Order regime’s policies and Muslims’ behaviors who were deemed inconsistent with Islamic values. In the midst of a hegemonic and repressive political system, Misbah’s attitude was a high risk and faced with political pressure from the New Order regime. Second, the use of Qur’anic exegesis as a medium for expressing criticism was an unusual move. During the New Order era, various criticisms of the government were raised through the mass media, art performances, literary works, or extra-parliamentary movements on the streets, but Misbah used Qur’anic exegesis as a medium for criticism; an out of the ordinary choice. Finally, from a political standpoint, because of his Al-Iklīl, Misbah was able to escape the political pressures of the hegemonic New Order government, and in term of academic contribution, he was able to establish a new tradition in the history of Qur’anic interpretation in Indonesia.
On the Phenomenon of the Epic Novel: A New Monograph on Russian Classical Literature
Authors:   Yaroslavl State Pedagogical University named after K. D. Ushinsky, Fedotova Anna A.
Published: July 2023

Readers are invited to review a new collective monograph on the phenomenon of the epic novel, published under the scientific editorship of a DSc in Philology V. G. Andreeva (IWL RAS) and which is the result of the work of well-known specialists in Russian classics in Russia. Besides V. G. Andreeva, the authors of the monograph are A. V. Gulin, N. L. Ermolaeva, S. K. Kazakova, Yu. V. Lebedev, V. I. Melnik, N. G. Mikhnovets. The author of the review analyzes the structure of the monograph, emphasizes the breadth of coverage of the material, as well as an attractive for the reader and at the same time promising scientific approach to the issues under study. The monograph examines in detail the most significant novels of Russian literature of the second half of the 19th century. The seemingly heterogeneous literary material is comprehended from a single methodological point of view, and the term “epic novel” is the key theoretical concept for the monograph. The review characterizes the range of problems raised in the monograph, highlights the successful and non-trivial observations of the authors of the new book.
The Dreamer and the Underground Hero of M. Yu. Lermontov and F. M. Dostoevsky in the Light of the Ethical Teachings of A. A. Ukhtomsky
Authors:   P. G. Demidov Yaroslavl State University, Fedorova Elena A. , Lyubarets Victoria V. ,   P. G. Demidov Yaroslavl State University
Published: July 2023

Based on the ethical teaching of the religious thinker A. A. Ukhtomsky, the article traces and comprehends the development of the type of the Dreamer and Underground Hero in Lermontov and Dostoevsky’s stories and novels. Lermontov creates the image of the artist Lugin as a Dreamer (“Stoss”), and in the character traits of Krasinsky and Pechorin (“Princess Ligovskaya”), the features of the Underground Hero appear. In the work of Dostoevsky, the Dreamer appears not only in the story “White Nights,” but also in the story “Little Hero,” the story “Netochka Nezvanova.” The Underground Hero of Dostoevsky is depicted in the story “Notes from the Underground” and the novel “The Teenager.” The dreamers of both writers are immersed in the world of literature, music, theater, which develops their imagination. However, the characters of Dostoevsky, unlike Lermontov’s one, are able to commit an act and influence reality.
“All Sorts of Things,” Trediakovsky and “Fenelon”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Ivinskiy Aleksandr D.
Published: July 2023

The article is devoted to the analysis of V. K. Trediakovsky’s translation of “The True Politics of Noble Persons.” This text, the authorship of which was often attributed to F. Fenelon, influenced the development of Russian literary journalism in 1760–1770s. We show that “All Sorts of Things” (“Vsiakaia Vsiachina”) and the other literary magazines used the key ideas of savoir vivre ideology. At the same time, it was Trediakovsky who was one of the first, back in 1730s, who understood their role in shaping the ideology of absolutism. The new facts and interpretations make it possible to reconsider Trediakovsky’s reputation as a pathetic “buffoon” or even a “fool” of Russian literature, whose works were on the sidelines of the main movement of Russian culture.
Sevastopol Stories by L. N. Tolstoy as a Document of the Epoch
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Shcherbakova Marina I.
Published: July 2023

The article deals with the Sevastopol stories of Leo Tolstoy in comparison with memoir sources and documents reflecting the events of the Crimean War of 1853‒1856. The works of M. I. Bogdanovich, E. I. Totleben, H. J. Gubbenet, F. K. Zatler, N. I. Pirogov, N. V. Berg, O. I. Konstantinov demonstrate the examples of historical evidence. The article shows that the source of the genre nature of the Sevastopol stories was the military experience of the young officer Tolstoy, who created a panorama of events woven from a qualitatively different figurative and artistic material and having an immeasurably greater impact than statistics and official documents. The analysis covrers artistic techniques of the writer in the paintings of the Sevastopol hospital, the assault on the Malakhov Kurgan and the departure of the Russian army from Sevastopol. Summing up the results, it can be concluded that the artistic scale of the Sevastopol stories created by Tolstoy corresponds to the historical scale of military events. The author not only did not deviate from the historical truth, but revealed the tragic depth and sacred meaning of the Crimean War in Russian history.
Stem cell-based bioregenerative therapy of osteoporosis: literature review
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Nishkumay Olha ,   European Wellness Academy, Edenkoben, Germany, K.S.  Chan Mike ,   European Wellness Academy, Edenkoben, Germany, Nalapko Yuriy ,   European Wellness Academy, Edenkoben, Germany, Grygorieva Nataliia ,   D. F. Chebotarev State Institute of Gerontology of the National Academy  of  Sciences of Ukraine, Ukrainian Center of Osteoporosis, Kyiv, Ukraine, Nikitin Oleh ,   Bogomolets National Medical University, Kyiv, Ukraine, Kordubailo Ilya ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: July 2023

Aging is an inevitable process of our civilization. Since ancient times, scientists have tried to solve the mystery of aging. The research continues to this day. The most common diseases of old age are disorders of the musculoskeletal system. Among them, osteoporosis continues to occupy the third place in the structure of overall morbidity and mortality. Such statistical data make us think about the search for a possible cause of the disease at the molecular level. The purpose of this study was to analyze the literature data on modern directions of osteoporosis treatment, including stem-cells based bioregenerative medicine. An analytical review of literature data was conducted using the information analysis of Medline (PubMed), Web of Science and Scopus databases, Google Scholar and the Cochrane Central Register of Controlled Trials (CENTRAL) from 2018 to 2022 using the keywords “osteoporosis”, bioregenerative therapy”, “stem cell therapy”. Recent results of preclinical experimental studies have shown the effectiveness of the introduction of new bioregenerative technologies. In particular, the use of mesenchymal stem cells, exosomes and miRNAs. Preclinical studies on MSC transplantation in the treatment of osteoporosis indicate an increase in osteogenic differentiation, an increase in BMD. Exosomes also may play multiple roles in the treatment of osteoporosis: improving the disbalance between osteoclasts and osteoblasts, structural modification of exosomes and transmitters’ drug function. The promotion of bone regeneration of exosomes has been shown in animal models. Exosomes with active ingredients can treat a variety of skeletal disorders including osteoporosis and osteoporotic fractures. The results of recent research of the bone disorder treatment based on stem cells therapy have shown convincing prospects for new approaches.
Human umbilical cord-derived мesenchymal stromal cells mitigate lipopolysaccharide-induced liver injury in rats
Authors:   I. Horbachevsky Ternopil National Medical University, Redko O , Dovgalyuk A. ,   I. Horbachevsky Ternopil National Medical University, Nebesna Z. ,   I. Horbachevsky Ternopil National Medical University, Kramar S. ,   I. Horbachevsky Ternopil National Medical University, Sverstyuk A. ,   I. Horbachevsky Ternopil National Medical University, Korda M. ,   I. Horbachevsky Ternopil National Medical University
Published: July 2023

Acute Respiratory Distress Syndrome (ARDS) is a severe clinical condition that can cause multi-organ dysfunction, including liver injury. Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) have been shown to possess therapeutic potential for a variety of diseases due to their ability to differentiate into various cell types and their anti-inflammatory and immunomodulatory properties. Purpose: To investigate the potential of hUC-MSCs for treating lipopolysaccharide (LPS)-induced liver injury in rats. Materials and methods: 72 mature male Wistar rats were randomly assigned to nine groups: control, 3 days, 7 days, and 28 days after intranasal administration of LPS, 24 hours of LPS and 2 days of hUC-MSCs, 4 days of LPS and 3 days of hUC-MSCs, 14 days of LPS and 14 days of hUC-MSCs, 21 days of LPS and 7 days of hUC-MSCs injection, and control 3 days after hUC-MSCs injection. The isolation of MSCs from human umbilical cord tissue was performed using an enzymatic digestion method with collagenase I. hUC-MSCs were injected intraperitoneally at a dose of 1∙106 cells/kg body weight. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were measured using the kinetic method. The levels of hepatocellular necrosis, liver structural damage, hepatocyte vacuolation, inflammation and disseminated intravascular coagulation (DIC) were analyzed by histological scoring of sections stained with hematoxylin and eosin. The expression of TGF-β1 in the liver tissue was evaluated by immunohistochemistry. Results: The preclinical study demonstrated that treatment with hUC-MSCs significantly improved liver function and attenuated LPS-induced liver injury in rats. This was evidenced by a reduction in hepatocellular necrosis, liver structural damage, hepatocyte vacuolation, inflammation, signs of DIC, fibrosis and lower levels of serum liver markers ALT, AST and ALP in the hUC-MSCs-treated groups compared to the untreated groups. The study also revealed that the use of hUC-MSCs was more effective at the earlier stage of liver injury. Conclusions: Our findings suggest that hUC-MSCs therapy may hold promise as a potential treatment for LPS-induced liver injury. Further research is needed to better understand the underlying mechanisms and to determine the potential for hUC-MSCs therapy in clinical practice.
Generative A.I. helps extract ecological meaning from the complex three dimensional shapes of bird bills
Authors: Dinnage Russell , Kleineberg Marian
Published: July 2023

Data on the three dimensional shape of organismal morphology is becoming
increasingly availability, and forms part of a new revolution in
high-throughput phenomics that promises to help understand ecological
and evolutionary processes that influence phenotypes at unprecedented
scales. However, in order to meet the potential of this revolution we
need new data analysis tools to deal with the complexity and
heterogeneity of large-scale phenotypic data such as 3D shapes. In this
study we explore the potential of generative Artificial Intelligence to
help organise and extract meaning from complex 3D data. Specifically, we
train a deep representational learning method known as DeepSDF on a
dataset of 3D scans of the bills of 2,020 bird species. The model is
designed to learn a continuous vector representation of 3D shapes, along
with a ‘decoder’ function, that allows the transformation from this
vector space to the original 3d morphological space. We find that
approach successfully learns coherent representations: particular
directions in latent space are associated with discernible morphological
meaning (such as elongation, flattening, etc.). More importantly,
learned latent vectors have ecological meaning as shown by their ability
to predict the trophic niche of the bird each bill belongs to with a
high degree of accuracy. Unlike existing 3D morphometric techniques,
this method has very little requirements for human supervised tasks such
as landmark placement, increasing it accessibility to labs with fewer
labour resources. It has fewer strong assumptions than alternative
dimension reduction techniques such as PCA. The computational
requirements for training the model, while substantial, is still within
the reasonable reach of most researchers, with a ~2000
shape model taking just over 2 days to train on only a single current
generation consumer-level GPU. Once trained, 3D morphology predictions
can be made from latent vectors very computationally cheaply.
Pride and Prejudice: What Influences Australians’ Attitudes towards Changing the Date of Australia Day?
Authors: Mortimer-Royle Eliza , Webb Stephanie , McLinton Sarven , Watkins Michael , Clark Yvonne
Published: July 2023

Australia Day, celebrated on January 26, is rooted in Australia’s
colonial history and causes pain for many of Australia’s First Peoples.
This study was the first to investigate predictors of Australians’
attitudes towards the date, whilst exploring whether intervention may
improve attitudes towards a date-change. An Australian community sample
( N=559) were recruited through social media for an anonymous survey.
Participants indicated their support for date-change, and responded to a
variety of demographic (e.g., Age) and sociodemographic (e.g., Racism)
questions, then being randomly allocated to an intervention statement,
indicating their final attitudes post-intervention. Findings suggest
sociodemographic factors were more important predictors than
demographics, with Racism ( β =.50***), Traditionalism ( β
=.18**), Patriotism ( β =.13*) and Age ( β =.10*)
significantly predicting participants’ date-change resistance. Racism
demonstrated the most predictive strength, underscoring the importance
of a date-change, with those open to change often identifying any
alternative date should not offend First Peoples. In addition,
intervention produced significant improvement in participants’
date-change attitudes, among those able to become more open to a
date-change; however, differences were not present between intervention
conditions. This illuminates the factors predicting Australians’
attitudes towards Australia Day, whilst demonstrating a potential path
towards date-change through intervention.

If you wish to learn more about this study, please contact the
primary author
at morea005@mymail.unisa.edu.au.
A New Control Method with Simplified Model and Kalman Filter Estimator for Grid-Tied Inverter with Asymmetric LCL Filter
Authors: Gao Chunxiao
Published: July 2023

In grid-tied inverter (GTI) systems, the three-phase asymmetric
LCL (A- LCL) filter has outstanding characteristics of
simple structure, almost the smallest total inductance, and the strong
resistance to the adverse effects of parameter shifts. Nevertheless, the
order of this kind of power filter is high, and the control model is
complicated due to its asymmetric structure. In this paper, a simplified
modeling method, which effectively reduces the system order is proposed,
without affecting the control performance. Then, the Kalman filter
estimation (KF-estimation) is adopted to estimate the voltage at the
point of common coupling (PCC) of the phase locked loop (PLL), which
saves the voltage sensors, saves the costs, and improves the system’s
ability to resist hardware failures. A 380 V/50 Hz/6 kW three-phase
laboratory setup has been developed to verify the correctness and
effectiveness of the proposed control method.