bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient Data Exchange between WebAssembly Modules
Authors: Silva Lucas , Metrôlho José , Ribeiro Fernando
Published: September 2024

In the past two decades, there has been a noticeable decoupling of machines and operating systems. In this context, WebAssembly has emerged as a promising alternative to traditional virtual machines. Originally designed for execution in web browsers, it has expanded to executing code in restricted and secure environments, and it stands out for its rapid startup, small footprint, and portability. However, WebAssembly presents significant challenges in data transfer and the management of interactions with the module. Its specification requires each module to have its own memory, resulting in a “share-nothing” architecture. This restriction, combined with the limitations of importing and exporting functions that only handle numerical values, and the absence of an application binary interface (ABI) for sharing more complex data structures, leads to efficiency problems; these are exacerbated by the variety of programming languages that can be compiled and executed in the same environment. To address this inefficiency, the Karmem was designed and developed. It includes a new interface description language (IDL) aimed at facilitating the definition of data, functions, and relationships between modules. Additionally, a proprietary protocol—an optimized ABI for efficient data reading and minimal decoding cost—was created. A code generator capable of producing code for various programming languages was also conceived, ensuring harmonious interaction with the ABI and the foreign function interface. Finally, the compact runtime of Karmem, built atop a WebAssembly runtime, enables communication between modules and shared memory. Results of the experiments conducted show that Karmem represents an innovation in data communication for WASM in multiple environments and demonstrates the ability to overcome challenges of efficiency and interoperability.
Healthy Aging in Colombia 2018 and Its Variation in Relation to Social Conditions
Authors: Fernández-Ortiz Yesika Natali
Published: September 2024

The population aging in the region is occurring under scenarios of inequality, raising concerns about how the increase in life expectancy is experienced and what factors affect the quality of life of older adults. This research quantified the differentials of healthy aging in Colombia in 2018 and its association with social indicators through a cross-sectional, descriptive, and correlational observational study. Healthy aging was quantified using the Disability-Free Life Expectancy (DFLE) indicator and later correlated with social indicators and subjected to a Multiple Factor Analysis (MFA). The results showed a healthy life expectancy of 71.5 years for women and 66.9 years for men, with a disability expectancy of 8.3 and 6.4 years, respectively. Negative associations emerged with health problems, disability, lack of medical care, illiteracy, school absenteeism, and poverty, while higher education levels and retirement showed positive associations. The factor analysis by area of residence highlighted urban areas as conducive to healthy aging. In conclusion, the accelerated aging of the Colombian population faces health disparities that policies must address by improving education, economic security, and health services, especially for women and rural areas.
Deep Immune and RNA Profiling Revealed Distinct Circulating CD163+ Monocytes in Diabetes-Related Complications
Authors: Siwan Elisha , Wong Jencia , Brooks Belinda A. , Shinko Diana , Baker Callum J. , Deshpande Nandan , McLennan Susan V. , Twigg Stephen M. , Min Danqing
Published: September 2024

CD163, a scavenger receptor with anti-inflammatory function expressed exclusively on monocytes/macrophages, is dysregulated in cases of diabetes complications. This study aimed to characterize circulating CD163+ monocytes in the presence (D+Comps) or absence (D−Comps) of diabetes-related complications. RNA-sequencing and mass cytometry were conducted on CD163+ monocytes in adults with long-duration diabetes and D+Comps or D−Comps. Out of 10,868 differentially expressed genes identified between D+Comps and D−Comps, 885 were up-regulated and 190 were down-regulated with a ≥ 1.5-fold change. In D+Comps, ‘regulation of centrosome cycle’ genes were enriched 6.7-fold compared to the reference genome. MIR27A, MIR3648-1, and MIR23A, the most up-regulated and CD200R1, the most down-regulated gene, were detected in D+Comps from the list of 75 ‘genes of interest’. CD163+ monocytes in D+Comps had a low proportion of recruitment markers CCR5, CD11b, CD11c, CD31, and immune regulation markers CD39 and CD86. A gene–protein network identified down-regulated TLR4 and CD11b as ‘hub-nodes’. In conclusion, this study reports novel insights into CD163+ monocyte dysregulation in diabetes-related complications. Enriched centrosome cycle genes and up-regulated miRNAs linked to apoptosis, coupled with down-regulated monocyte activation, recruitment, and immune regulation, suggest functionally distinct CD163+ monocytes in cases of diabetes complications. Further investigation is needed to confirm their role in diabetes-related tissue damage.
Galectin-8 Contributes to Human Trophoblast Cell Invasion
Authors: Legner Janko , Jovanović Krivokuća Milica , Vilotić Aleksandra , Pirković Andrea , Nacka-Aleksić Mirjana , Bojić-Trbojević Žanka
Published: September 2024

Galectins are a class of lectins that are extensively expressed in all organisms. Galectins are involved in a range of functions, including early development, tissue regeneration, cancer and inflammation. It has been shown that galectin-8 is expressed in the villous and extravillous trophoblast (EVT) cells of the human placenta; however, its physiological role in pregnancy establishment has not been elucidated. Taking these factors into account, we investigated the functional role of galectin-8 in HTR-8/SVneo cells—a human EVT cell line—and human primary cytotrophoblast cells isolated from a first-trimester placenta. We analyzed the effects of recombinant human galectin-8 (rh galectin-8) on the adhesion, migration and invasion of HTR-8/SVneo cells. We used qPCR, cell-based ELISA (cELISA) and gelatin zymography to study the effects of galectin-8 on mediators of these processes, such as integrin subunits alpha-1 and beta-1 and matrix metalloproteinases (MMPs)-2 and -9, on the mRNA and protein levels. Further, we studied the effects of galectin-8 on primary cytotrophoblast cells’ invasion. Galectin-8 stimulated the adhesion, migration and invasion of HTR-8/SVneo cells, as well as the invasion of primary cytotrophoblasts. In addition, the MMP-2 and -9 levels were increased, while the expression of integrins alpha-1 and beta-1 was not affected. Galectin-8 has the ability to positively affect EVTs’ invasion, so it can be considered a significant factor in the trophoblast cell invasion process.
The Hidden Relationship between Intestinal Microbiota and Immunological Modifications in Preeclampsia Pathogenesis
Authors: Zambella Enrica , Peruffo Beatrice , Guarano Alice , Inversetti Annalisa , Di Simone Nicoletta
Published: September 2024

Preeclampsia is a multifactorial gestational syndrome characterized by increased blood pressure during pregnancy associated with multiorgan involvement. The impact of this disease on maternal and neonatal health is significant, as it can lead to various fetal comorbidities and contribute to the development of maternal comorbidities later in life. Consistent evidence has shown that the microbiota acts as a regulator of the immune system, and it may, therefore, influence the development of preeclampsia by modulating immune factors. This narrative review aims to investigate the role of the immune system in the pathogenesis of preeclampsia and to summarize the most recent literature on the possible link between preeclampsia and alterations in the intestinal microbiota. To this end, we conducted a literature search, aiming to perform a narrative review, on PubMed and Embase from January 1990 to March 2024, focusing on the latest studies that highlight the main differences in microbial composition between patients with and without preeclampsia, as well as the effects of microbial metabolites on the immune system. From the review of 28 studies assessing the intestinal microbiota in preeclamptic women, preeclampsia could be associated with a state of dysbiosis. Moreover, these patients showed higher plasmatic levels of endotoxin, pro-inflammatory cytokines, and T helper 17 cells; however, the findings on specific microbes and metabolites that could cause immune imbalances in preeclampsia are still preliminary.
Molecular Mechanisms Underlying Freezing Tolerance in Plants: Implications for Cryopreservation
Authors: Białoskórska Magdalena , Rucińska Anna , Boczkowska Maja
Published: September 2024

Cryopreservation is a crucial technique for the long-term ex situ conservation of plant genetic resources, particularly in the context of global biodiversity decline. This process entails freezing biological material at ultra-low temperatures using liquid nitrogen, which effectively halts metabolic activities and preserves plant tissues over extended periods. Over the past seven decades, a plethora of techniques for cryopreserving plant materials have been developed. These include slow freezing, vitrification, encapsulation dehydration, encapsulation–vitrification, droplet vitrification, cryo-plates, and cryo-mesh techniques. A key challenge in the advancement of cryopreservation lies in our ability to understand the molecular processes underlying plant freezing tolerance. These mechanisms include cold acclimatization, the activation of cold-responsive genes through pathways such as the ICE–CBF–COR cascade, and the protective roles of transcription factors, non-coding RNAs, and epigenetic modifications. Furthermore, specialized proteins, such as antifreeze proteins (AFPs) and late embryogenesis abundant (LEA) proteins, play crucial roles in protecting plant cells during freezing and thawing. Despite its potential, cryopreservation faces significant challenges, particularly in standardizing protocols for a wide range of plant species, especially those from tropical and subtropical regions. This review highlights the importance of ongoing research and the integration of omics technologies to improve cryopreservation techniques, ensuring their effectiveness across diverse plant species and contributing to global efforts regarding biodiversity conservation.
Genome-Wide Identification and Expression Analysis of the Cyclic Nucleotide-Gated Channel Gene Family in Zoysia japonica under Salt Stress
Authors: Li Shu-Tong , Kong Wei-Yi , Chen Jing-Bo , Hao Dong-Li , Guo Hai-Lin
Published: September 2024

Salt stress severely inhibits plant growth. Understanding the mechanism of plant salt tolerance is highly important to improving plant salt tolerance. Previous studies have shown that nonselective cyclic nucleotide-gated ion channels (CNGCs) play an important role in plant salt tolerance. However, current research on CNGCs mainly focuses on CNGCs in glycophytic plants, and research on CNGCs in halophytes that exhibit special salt tolerance strategies is still scarce. This study used the halophilic plant Zoysia japonica, an excellent warm-season turfgrass, as the experimental material. Through bioinformatics analysis, 18 members of the CNGC family were identified in Zoysia japonica; they were designated ZjCNGC1 through ZjCNGC18 according to their scaffold-level chromosomal positions. ZjCNGCs are divided into four groups (I–IV), with the same groups having differentiated protein-conserved domains and gene structures. ZjCNGCs are unevenly distributed on 16 scaffold-level chromosomes. Compared with other species, the ZjCNGCs in Group III exhibit obvious gene expansion, mainly due to duplication of gene segments. The collinearity between ZjCNGCs, OsCNGCs, and SjCNGCs suggests that CNGCs are evolutionarily conserved among gramineous plants. However, the Group III ZjCNGCs are only partially collinear with OsCNGCs and SjCNGCs, implying that the expansion of Group III ZjCNGC genes may have been an independent event occurring in Zoysia japonica. Protein interaction prediction revealed that ZjCNGCs, calcium-dependent protein kinase, H+-ATPase, outwardly rectifying potassium channel protein, and polyubiquitin 3 interact with ZjCNGCs. Multiple stress response regulatory elements, including those involved in salt stress, are present on the ZjCNGC promoter. The qPCR results revealed differences in the expression patterns of ZjCNGCs in different parts of the plant. Under salt stress conditions, the expression of ZjCNGCs was significantly upregulated in roots and leaves, with ZjCNGC8 and ZjCNGC13 showing the greatest increase in expression in the roots. These results collectively suggest that ZjCNGCs play an important role in salt tolerance and that their expansion into Group III may be a special mechanism underlying the salt tolerance of Zoysia japonica.
In Vitro Proliferation of MG-63 Cells in Additively Manufactured Ti-6Al-4V Biomimetic Lattice Structures with Varying Strut Geometry and Porosity
Authors: Papazoglou Dimitri P. , Hobbs Laura , Sun Yvonne , Neidhard-Doll Amy
Published: September 2024

Lattice structures have demonstrated the ability to provide secondary stability in orthopedic implants by promoting internal bone growth. In response to the growing prevalence of lattices in orthopedic design, we investigated the effects of porosity and unit cell geometry in additively manufactured Ti-6Al-4V biomimetic lattice structures on the osteogenesis of human MG-63 osteoblastic cell lines in vitro. We analyzed glucose consumption, alkaline phosphatase (ALP) concentration, and end-of-culture cell count as markers for osteogenic growth. Two different strut geometries were utilized (cubic and body-centered cubic), along with four different pore sizes (400, 500, 600, and 900 µm, representing 40–90% porosity in a 10 mm cube), in addition to a solid specimen. Structural characterization was performed using scanning electron microscopy. The results indicated that lattices with a 900 µm pore size exhibited the highest glucose consumption, the greatest change in ALP activity, and the highest cell count when compared to other pore sizes. Cubic 900 µm lattice structures outperformed other specimens in facilitating the maturation of viable MG-63 cells from the formation to the mineralization phase of bone remodeling, offering the most promise for osseointegration in additively manufactured titanium implants in the future. However, irrespective of a particular pore size or unit cell geometry, it was found that all the lattices were capable of promoting osteogenic growth due to surface roughness in the printed parts.
Utilization of Municipal Solid Waste Incineration (MSWIFA) in Geopolymer Concrete: A Study on Compressive Strength and Leaching Characteristics
Authors: Xu Qiyong , Shang Ning , Ko Jae Hac
Published: September 2024

This study explores the utilization of municipal solid waste incineration fly ash (MSWIFA) in geopolymer concrete, focusing on compressive strength and heavy metal leachability. MSWIFA was sourced from a Shenzhen waste incineration plant and pretreated by washing to remove soluble salts. Geopolymer concrete was prepared incorporate with washed or unwashed MSWIFA and tested under different pH conditions (2.88, 4.20, and 10.0). Optimal compressive strength was achieved with a Si/Al ratio of 1.5, water/Na ratio of 10, and sand-binder ratio of 0.6. The washing pretreatment significantly enhanced compressive strength, particularly under alkaline conditions, with GP-WFA (washed MSWIFA) exhibiting a 49.6% increase in compressive strength, compared to a 21.3% increase in GP-FA (unwashed MSWIFA). Additionally, GP-WFA’s compressive strength reached 41.7 MPa, comparable to that of the control (GP-control) at 43.7 MPa. Leaching tests showed that acidic conditions (pH 2.88) promoted heavy metal leaching, which increased over the leaching time, while an alkaline environment significantly reduced the leachability of heavy metals. These findings highlight the potential of using washed MSWIFA in geopolymer concrete, promoting sustainable construction practices, particularly in alkaline conditions.
Analysis of Thermophysical Properties of Electro Slag Remelting and Evaluation of Metallographic Cleanliness of Steel
Authors: Walek Josef , Odehnalová Adéla , Kocich Radim
Published: September 2024

Improving the competitiveness of steel companies is linked to sustainable, quality-compliant steel production. Therefore, new steel production technologies contributing to increased cleanliness of steel are continuously being developed and optimized. One way to achieve a high steel quality is to use electro slag remelting (ESR) technology. In this paper, the principle of ESR technology and the importance of fused slags for optimizing the process are outlined. The aim of this work was to analyze the main thermophysical properties of steel and fused slags used in the ESR process. Determination of the properties of steel and slags was performed using the FactSage calculation software, which involved the calculation of the liquid and solid temperature of steel and slags, the calculation and construction of quaternary diagrams, and the calculation of viscosity. The resulting quaternary diagrams revealed the substantial influence of chemical composition on melting temperatures of slags. In order to validate the acquired results, a CrNiMoV-type steel was subjected to investigation of its metallographic cleanliness and evaluation of its mechanical properties; the ESR process was shown to significantly improve the cleanliness of the steel and improve the mechanical properties of the steel compared to its cleanliness and quality when produced via vacuum degassing (VD) technology. During the ESR process, the average size of non-metallic inclusions was reduced from 20 μm to 10 μm, and the maximum size of non-metallic inclusions was reduced from 50 μm to 28 μm. The mechanical properties of the steel produced using ESR technology were impacted as follows: the ductility increased by 10%, contraction increased by 18%, notched toughness at 20 °C increased by 46%, and at −40 °C (respectively −50 °C) it increased by 30%.
Investigation of the Temperature and Horizontal Freezing Force of Loess in Three-Dimensional Freezing
Authors: Yin Yidan , Liu Fei , Tang Dongqi , Chen Longze , Yang Binbin
Published: September 2024

Seasonal frozen soil has significant impacts on changes in soil mechanical properties, settlement, and damage to foundations. In order to study variations in the temperature and horizontal freezing force of loess during three-dimensional freezing, a three-dimensional freezing model test of loess was carried out. This experiment analyzed and studied the soil temperature change distribution characteristics, horizontal freezing force distribution rules, and water migration phenomena caused by temperature. The research results show that the temperature change in soil samples exhibits a “ring-like” decrease from the outside to the inside. When the soil temperature reaches the supercooling point, the cooling curve jumps and rises, and this is accompanied by a stable section with constant temperature. In the late freezing period, the temperature rate drops slowly. Under the action of freezing, the horizontal freezing forces at different positions have similar change characteristics and can be divided into four change stages: stable stage, rapid freezing stage, “secondary” freezing stage, and freezing–shrinkage–rebound stable stage. At lower moisture contents, loess samples undergo freeze–thaw shrinkage during the freezing process. During the rapid freezing stage of soil samples, the water in the soil sample migrates and causes secondary freezing. After the rapid freezing stage, the soil temperature continues to decrease, and the horizontal freezing force no longer decreases.
Fabrication of a Novel Z-Scheme AgBiO3/BiOCl Heterojunction with Excellent Photocatalytic Performance towards Organic Pollutant
Authors: Fu Shuai , Huang Zhiquan , Wang Yanhong , Zheng Bingqian , Yuan Wei , Li Leicheng , Deng Peiyuan , Zhu Huijie , Zhang Hui , Liu Bo
Published: September 2024

A novel and highly efficient photocatalyst of a AgBiO3/BiOCl heterojunction has been developed via a facile water bath and in situ precipitation method. The photocatalytic activities of the catalysts were investigated by the degradation of ciprofloxacin (CIP) under visible-light irradiation (>420 nm). The experiment results revealed that the photocatalytic performance of the optimized AgBiO3/BiOCl heterojunction was much higher than pure AgBiO3 and BiOCl. The degradation efficiency of the as-prepared AgBiO3/BiOCl heterojunction (ABC-30) for CIP could reach 88% within 160 min, with 2.89 and 3.76 times higher activity than pure AgBiO3 and BiOCl, respectively. The improved photocatalytic performance of AgBiO3/BiOCl was attributed to the synergistic effect of the enhanced light absorption range and effective separation and transfer of the photo-induced charge carrier. The optimized heterojunction showed broad-spectrum catalytic activities towards various organic contaminants. The degradation efficiencies varied with the nature of the pollutant and decreased in the following order: Lanasol Red 5B (100%) > methyl orange (99%) > methylene blue (98%) > tetracycline (92%) > ciprofloxacin (88%) > ofloxacin (85%) > norfloxacin (78%) > rhodamine B (59%) > metronidazole (43%) > phenol (40%) > carbamazepine (20%). Furthermore, the trapping experiments and ESR indicated that superoxide radicals and holes were the main reactive species.
Research on the Corrosion Resistance of Electrodeposited Ni-SiC Composites Constructed for Steel Storage Tank Application
Authors: Cui Lifu , Li Xiang , Li Chaoyu , Zhu Lijie , Zhang Qinggao , Li Zheng , Liu Haiyu
Published: September 2024

In this paper, the effects of the SiC phase incorporated in Ni substrate deposits on storage tank steel during electrodeposition at different current densities are explored. The microstructure, phase content, and corrosion resistance of the resulting Ni-SiC composites were investigated by scanning electron microscopy (SEM) matched with energy disperse spectroscopy (EDS), X-ray diffraction (XRD), and an electrochemical workstation, respectively. SEM micrographs and EDS results show that at 2.5 A/dm2, the composites presented a smooth and compact structure with high SiC content, while at 1.8 or 3.2 A/dm2, it became uneven and loose in structure with low SiC content. XRD patterns showed that the nickel grain size of composites firstly increased and then decreased with the growth of the current density. Notably, the Ni-SiC composite produced at 2.5 A/dm2 possessed a higher corrosion potential (−0.507 V) and lower corrosion current density (2.439 μA/cm2), illustrating that its excellent anti-corrosion ability was superior than that of other two composites. Hence, SiC co-deposited at 2.5 A/dm2 conducted as a protective barrier and inhibited the corrosion rate against a corrosion medium of Cl− and SO42− ions. In addition, the corrosion relationship illustrated that the SiC content of Ni-SiC composite firstly increased and then decreased with the growth of the current density, while the corrosion weight loss of Ni-SiC composites firstly decreased and then increased.
Effect of Process Conditions on the Microstructure and Properties of Supercritical Ni-GQDs Plating
Authors: Zhong Haoyu , Fang Cong , Lei Weining , Xv Tianle , He Bin , Kong Linglei , He Yiliang
Published: September 2024

The Ni-GQDs composite plating was created using direct current (DC), single-pulse, and double-pulse power supplies, with GQDs serving as additives under supercritical CO2 conditions. A comparative analysis was conducted to evaluate the effects of different electrodeposition power sources on the microstructure and properties of the Ni-GQDs composite plating. High-Resolution Transmission Electron Microscopy (HRTEM) was employed to investigate the distribution of GQDs within the composite plating as well as to analyze d-spacing and diffraction patterns. Scanning Electron Microscopy (SEM) was utilized to illustrate the surface morphology of the plating and assess its surface quality. The grain size and preferred orientation of the plated layer were examined using X-ray Diffraction (XRD), while Atomic Force Microscopy (AFM) was used to evaluate the roughness of the surface. To compare the abrasion resistance of the various plating types, wear amounts and friction coefficients were measured through friction and wear tests. Additionally, corrosion resistance tests were performed to assess the corrosion resistance of each plating variant. The results indicate that the Ni-GQDs-III composite layers produced via double-pulse electrodeposition exhibit superior surface quality, characterized by smaller grain sizes, enhanced surface flatness, reduced surface roughness, and improved resistance to wear and corrosion.
Immunomodulatory Effects of Halichondrin Isolated from Marine Sponges and Its Synthetic Analogs in Oncological Applications
Authors: Dissanayake Dinusha Shiromala , Nagahawatta Dineth Pramuditha , Lee Jung-Suck , Jeon You-Jin
Published: September 2024

Marine natural products comprise unique chemical structures and vast varieties of biological activities. This review aims to summarize halichondrin, a marine natural product, and its synthetic analogs along with its therapeutic properties and mechanisms. Halichondrin and its analogs, derived from marine sponges, exhibit potent antineoplastic properties, making them promising candidates for cancer therapeutics. These compounds, characterized by their complex molecular structures, have demonstrated significant efficacy in inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis in various cancer cell lines. Several types of halichondrins such as halichondrins B, C, norhalichondrin B, and homohalichondrin B have been discovered with similar anticancer and antitumor characteristics. Since naturally available halichondrins show hurdles in synthesis, recent advancements in synthetic methodologies have enabled the development of several halichondrin analogs, such as E7389 (eribulin), which have shown improved therapeutic indices. Eribulin has shown excellent immunomodulatory properties by several mechanisms such as reprogramming tumor microenvironments, facilitating the infiltration and activation of immune cells, and inhibiting microtubule dynamics. Despite promising results, challenges remain in the synthesis and clinical application of these compounds. This review explores the mechanisms underlying the immunomodulatory activity of halichondrin and its analogs in cancer therapy, along with their clinical applications and potential for future drug development.
Effect on Satiety-Related Biomarkers of Bar Snacks Containing Chickpea Flour and Pork Protein
Authors: Zomeño María-Dolores , Malcampo Mireia , Pérez-Vega Karla Alejandra , Pastor Antoni , López-Roura Maria , Arrufat Begoña , Atarés Sergio , Ramos Sergio José , Alonso David , Subirana Isaac , Muñoz-Aguayo Daniel , Blanchart Gemma , Gaixas Sònia , Cabañero Marta , Tello Susanna , Konstantinidou Valentini , Hernando-Redondo Javier , Goday Albert , Castañer Olga , Schröder Helmut , Fitó Montserrat
Published: September 2024

This project aims to establish the acceptability and satiety of a hybrid snack containing plant protein and a small percentage of animal protein compared to a meat-based snack. Design: Randomised, crossover, double-blind, controlled post-prandial trial involving 24 participants (18–30 years), with two interventions: (a) a hybrid snack containing plant protein derived from chickpeas and 6.6% lean high-quality pork meat; and (b) a meat-based snack containing 90% lean pork meat. Methods: General, life-style, sensory acceptability questionnaire, and the following laboratory analyses were performed: lipid profile, endocannabinoids, and related compounds. Results: Sensory questionnaires showed in general good acceptability for both bars. Additionally, there was a greater increase in glycemia at 30, 60, and 90 min after consuming the hybrid snack compared to the meat-based snack, with no changes in the lipid profile. Regarding the endocannabinoid compounds and related compounds, the compound N-palmitoleoyl ethanolamine in the acylethanolamide group showed higher levels overall following the consumption of the hybrid snack compared to the meat-based snack, particularly at 2 h. Conclusions: The hybrid snack was associated with changes in endocannabinoid-like compounds. Therefore, it may provide a lasting satiating effect, while complementing the protein profile of plant-based foods with the quality of animal protein.
Adherence to Nutritional Practice Guideline in Premature Infants: A Nationwide Survey in Taiwan
Authors: Ting Chi-Shiuan , Tsao Po-Nien , Chou Hung-Chieh , Yen Ting-An , Huang Hsin-Chung , Chen Chien-Yi
Published: September 2024

Objectives: This study aimed to assess the current neonatal nutritional practices in Taiwan and promote consensus on standardized protocols. Methods: An online questionnaire comprising 95 items on parenteral nutrition (PN) and enteral nutrition (EN) practices was distributed to neonatal care units across Taiwan via email between August and December 2022. The responses were compared with the recommendations from the European Society for Pediatric Gastroenterology Hepatology and Nutrition for preterm infant care. Results: Most of the 35 neonatal units, comprising 17 level III and 18 level II units, that participated in this study adhered to standard PN protocols; however, only 30% of units used protein-containing solutions as the initial fluid. Over half of the neonatal units provided calcium, phosphate, and magnesium at less than the recommended dosage. Trophic feeding commenced within 48 h in 88% of the units, with the mother’s milk used as the first choice. All the units preferred commencing advanced feeding at <25 mL/kg/day. Conclusions: Most nutrient protocols for preterm infants in neonatal units in Taiwan meet recent guidelines, but discrepancies such as lower mineral supplements in PN and a slower advancement of enteral feeding increase nutritional risk. These issues warrant further research.
Capsinoids Increase Antioxidative Enzyme Activity and Prevent Obesity-Induced Cardiac Injury without Positively Modulating Body Fat Accumulation and Cardiac Oxidative Biomarkers
Authors: Santos Késsia Cristina Carvalho , Domingos Lucas Furtado , Nunes Fabiane Merigueti , Simmer Luisa Martins , Cordeiro Evellyn Rodrigues , Filetti Filipe Martinuzo , Bocalini Danilo Sales , Corrêa Camila Renata , Lima-Leopoldo Ana Paula , Leopoldo André Soares
Published: September 2024

Background/Objectives: Capsinoids are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, this study aimed to investigate the effects of capsinoids on adiposity and biomarkers of cardiac oxidative stress in obese rats induced by a high-fat diet. Methods: Male Wistar rats were exposed to a high-fat diet for 27 consecutive weeks. After the characterization of obesity (week 19), some of the obese animals began to receive capsinoids (10 mg/kg/day) by orogastric gavage. Adiposity and comorbidities were assessed. In the heart, remodeling, injury, and biomarkers of oxidative stress were determined. Results: The treatment did not reduce obesity-induced adiposity but was efficient in reducing cholesterol levels. Capsinoid treatment did not cause a difference in heart and LV mass, despite having reduced troponin I concentrations. Furthermore, capsinoids did not reduce the increase in the advanced oxidation of protein products and carbonylated proteins caused by obesity in cardiac tissue. In addition, obese rats treated with capsinoids presented high levels of malondialdehyde and greater antioxidant enzyme activity compared to untreated obese rats. Conclusions: In conclusion, treatment with capsinoids increases antioxidative enzyme activity and prevents obesity-induced cardiac injury without positively modulating body fat accumulation and cardiac oxidative biomarkers.
Multifaceted Roles of Vitamin D for Diabetes: From Immunomodulatory Functions to Metabolic Regulations
Authors: Park Chan Yoon , Shin Sunhye , Han Sung Nim
Published: September 2024

Numerous studies have established associations between vitamin D and diabetes. The vitamin D receptor is widely distributed throughout the human body, including in pancreatic beta cells (β-cells), hepatocytes, and immune cells. Therefore, vitamin D’s effect on the risk, progression, or complications of diabetes may be mediated through various mechanisms. These include the regulation of insulin secretion or sensitivity and modulation of β-cell function and its immunomodulatory and anti-inflammatory effects. This review extensively explores the relationship between vitamin D status and diabetes, as well as the preventive or therapeutic effects of vitamin D supplementation on diabetes from human studies. Additionally, it examines in detail the impact of vitamin D on immune and inflammatory responses in the diabetic milieux and β-cell function to better understand the underlying mechanisms through which vitamin D influences diabetes.
Beneficial Effect of Dietary Approaches to Stop Hypertension Diet Combined with Regular Physical Activity on Fat Mass and Anthropometric and Metabolic Parameters in People with Overweight and Obesity
Authors: Soroń-Lisik Małgorzata , Więch Paweł , Dąbrowski Mariusz
Published: September 2024

Background/objective: Obesity and overweight have become growing health-related issues worldwide, which also applies to Poland. Excess fat mass is associated with an increased risk of metabolic and non-metabolic complications. The aim of our pre–post-designed study was to assess the effect of behavioral intervention on body weight, fat mass and anthropometric and metabolic parameters in obese and overweight individuals. Methods: The study included one hundred people (85 women) with excess fat mass who voluntarily declared their willingness to participate in the weight-loss program consisted of 12 weeks of the DASH diet combined with regular, supervised physical activity. Anthropometric measurements and laboratory tests were performed in all study participants, and anthropometric and metabolic indices were calculated at baseline and after three months of treatment. Results: Body weight decreased significantly by 5.63 ± 4.03 kg, BMI by 2.06 ± 1.44 kg/m2, waist circumference by 5.6 ± 3.7 cm, fat mass from 40.04 ± 6.90 to 36.56 ± 7.07% and uric acid level by 16.0 ± 41.6 μmol/L (p < 0.001 in all cases). We also found an improvement in lipid profile and anthropometric and metabolic indices, except for HDL cholesterol and plasma glucose levels. Conclusions: The effect of the DASH diet and supervised physical activity was beneficial regardless of age, sex and the presence of hypertension or dysglycemia at baseline. The implementation of a healthy lifestyle was associated with a significant improvement in anthropometric and metabolic parameters, which, if continued, may reduce the risk of unfavorable health-related outcomes in the future.
Statistical-Based Optimization of Modified Mangifera indica Fruit Starch as Substituent for Pharmaceutical Tableting Excipient
Authors: Chaksmithanont Prin , Bangsitthideth Ketsana , Arunprasert Kwanputtha , Patrojanasophon Prasopchai , Pornpitchanarong Chaiyakarn
Published: September 2024

This study aimed to optimize modified starch from Mangifera indica (mango) fruit using acid hydrolysis and pre-gelatinization via computer-assisted techniques as a substituent for pharmaceutical tableting excipients. The hydrolysis and microwave-assisted pre-gelatinization time and temperature were optimized using a three-level factorial design. The modified starches were characterized for flowability, compressibility, and swelling properties. It was found that all parameters fit a quadratic model, which can be used to predict the properties of the modified starch. The optimized hydrolysis reaction was 3.8 h at 56.4 °C, while the pre-gelatinization reaction was 3 min at 150 °C. Structural changes were found, ascertaining that starch modification was successful. The optimized hydrolyzed starch showed superior properties in relative to unmodified M. indica fruit starch and comparable characteristics to conventional excipients. The optimized pre-gelatinized starch presented an excellent enhancement in the flow and compression properties, with %swelling greatly augmented 3.95-fold and 1.24-fold compared to unmodified starch and SSG, respectively. Additionally, the pre-gelatinized starch presented comparable binding effect, while the hydrolyzed powder had reduced binding capacity due to shorter chains. The findings revealed that the use of software-assisted design of experiment facilitated a data-driven approach to optimize the modifications. The optimized modified mango starch demonstrated potential as a multifunctional excipient, capable of functioning as binder, disintegrant, and diluent.
The Catalytic Effect of Low Molecular Weight Acids on the Physicochemical and Dielectric Properties of Oil-Paper Insulation Systems
Authors: Kouassi Kakou D. , Fofana Issouf , Hadjadj Yazid , Yapi Kouba M. Lucia
Published: September 2024

In most industrialized countries, power transformers built several decades ago are approaching the end of their operational lifespan. The ongoing energy transition, focused on developing 100% renewable energy sources and accelerating global transportation electrification, further exacerbates these assets. Combined with rising electricity demand, there is an increasing risk of critical transformers’ degradation acceleration. In this context, understanding the aging mechanisms of the insulation system inside these essential assets, which form the core of every energy network, becomes paramount for today’s managers and engineers responsible for their operations. The acids generated through oil oxidation can be classified into two categories: low molecular weight acids (LMAs), which are inherently more hydrophilic and consequently have a greater impact on the degradation rate of solid insulation through hydrolysis, and high molecular weight acids (HMAs), which do not significantly contribute to the degradation of paper insulation. This study specifically addresses the impact of acids generated through oil oxidation—focusing on LMAs. New oil samples were infused with different ratios of LMAs before impregnation. The impregnated paper samples underwent thermal aging at 115 °C. Different physicochemical and dielectric properties were investigated. The investigations revealed that oils blended with formic acid exhibited more adverse effects on the insulation system compared to other LMAs. This information is essential for industry professionals seeking to mitigate the risks associated with transformer degradation and extend the lifespan of these critical assets during the energy transition.
Ship Wake Detection in a Single SAR Image via a Modified Low-Rank Constraint
Authors: Guan Yanan , Xu Huaping , Li Wei , Li Chunsheng
Published: September 2024

Ship wake detection stands as a pivotal task in marine environment monitoring. The main challenge in ship wake detection is to improve detection accuracy and mitigate false alarms. To address this challenge, a novel procedure for ship wake detection in a single SAR image is proposed in this study. Initially, an entropy distance similarity criterion is designed to measure nonlocal image patch similarity. Based on the proposed criterion, a low-rank and sparse decomposition method is modified using nonlocal similar patch matrix construction to separate the sparse wake. Subsequently, a field-of-experts (FOE) model is introduced to generate a series of multi-view wake feature maps, which are fused to construct an enhanced feature map. The sparse wake is further enhanced in the Radon domain with the enhanced feature map. The experimental results demonstrate the effectiveness of the proposed method on real SAR ship wake images.
Fine-Scale Eddies Detected by SWOT in the Kuroshio Extension
Authors: Du Tianshi , Jing Zhao
Published: September 2024

Conventional altimetry has greatly advanced our understanding of mesoscale eddies but falls short in studying fine-scale eddies (<150 km). The newly launched Surface Water and Ocean Topography (SWOT) altimeter, however, with its unprecedented high-resolution capabilities, offers new opportunities to observe these fine-scale eddies. In this study, we use SWOT data to explore these previously elusive fine-scale eddies in the Kuroshio Extension. During SWOT’s fast sampling phase from 29 May 2023 to 10 July 2023, we identified an average of 4.5 fine-scale eddies within each 120 km wide swath. Cyclonic eddies, which are slightly more frequent than the anticyclonic ones (ratio of 1.16), have a similar mean radius of 23.4 km. However, cyclonic eddies exhibit higher amplitudes, averaging 3.5 cm compared to 2.8 cm for anticyclonic eddies. In contrast to the mesoscale eddies detected by conventional altimeters, the fine-scale eddies revealed by SWOT are characterized by smaller sizes and weaker amplitudes. This study offers a preliminary view of fine-scale eddy characteristics from space, highlighting SWOT’s potential to advance our understanding of these dynamic processes. Nonetheless, it also emphasizes the necessity for comprehensive analysis to fully exploit the satellite’s capabilities in monitoring and interpreting complex eddy behaviors.
Modeling and Analyzing the Availability of Technical Professional Profiles for the Success of Smart Cities Projects in Europe
Authors: López-Baldominos Inés , Pospelova Vera , Fernández-Sanz Luis , Castillo-Martínez Ana
Published: September 2024

The success of developing and implementing Smart Cities (SC) projects depends on a varied set of factors, where the availability of a qualified technical workforce is a critical one. The combination of ICT requirements, like the effectiveness and quality of solutions merging IoT, cloud computing, sensors, and communications with the work from many varied disciplines (e.g., civil engineering, architecture, etc.), mixed with aspects of environmental and business sustainability, makes the management of these projects really challenging. Reports forecast a scarcity of qualified candidates, given this complexity and the growth of activity in SC projects. The European project SMACITE has addressed the requirements of the qualification of an ICT workforce with an analysis of multiples sources of information from the labor market, feedback from involved stakeholders, and the literature. The goal was the development of two occupational ICT profiles as a reference for training and for the availability of candidates for job vacancies. The result is two ICT role profiles for engineers and technicians, mapped with the European skills frameworks ESCO and EN16234. The profiles determined the whole set of requirements, including not only the technical areas and soft skills, but also additional technical areas and sustainability and managerial skills and the analysis of different sources of information. Our work has also determined which existing ESCO occupations are similar to the two reference profiles, so they are better adapted to SC projects. The training activities of SMACITE have also suggested the amount of training expected for a varied sample of candidates who want to be qualified for SC projects.
Reliability of Real-Time Kinematic (RTK) Positioning for Low-Cost Drones’ Navigation across Global Navigation Satellite System (GNSS) Critical Environments
Authors: Tavasci Luca , Nex Francesco , Gandolfi Stefano
Published: September 2024

UAVs are nowadays used for several surveying activities, some of which imply flying close to tall walls, in and out of tunnels, under bridges, and so forth. In these applications, RTK GNSS positioning delivers results with very variable quality. It allows for centimetric-level kinematic navigation in real time in ideal conditions, but limitations in sky visibility or strong multipath effects negatively impact the positioning quality. This paper aims at assessing the RTK positioning limitations for lightweight and low-cost drones carrying cheap GNSS modules when used to fly in some meaningful critical operational conditions. Three demanding scenarios have been set up simulating the trajectories of drones in tasks such as infrastructure (i.e., building or bridges) inspection. Different outage durations, flight dynamics, and obstacle sizes have been considered in this work to have a complete overview of the positioning quality. The performed tests have allowed us to define practical recommendations to safely fly drones in potentially critical environments just by considering common software and standard GNSS parameters.
Application of Indoor Positioning Systems in Nursing Homes: Enhancing Resident Safety and Staff Efficiency
Authors: Lee Chia-Rong , Chu Edward T.-H. , Sie Min-Jing , Lin Li-Tsai , Hong Mei-Zhen , Huang Ching-Chih
Published: September 2024

Providing a safe and secure living environment for residents that is supported by a dedicated healthcare team is one of the core values of nursing homes. Nursing homes must protect residents from the risk of going missing, track quarantined residents and visitors to control the spread of infection, and maintain proactive nursing rounds. However, recruiting and retaining qualified caregivers and medical staff has long been a challenge. Therefore, using advanced technology to ensure the safety and security of residents is highly desirable. In this work, we first demonstrate the applicability of indoor tracking applications in a nursing home, such as resident and asset tracking, nursing assistant management, visitor tracking, infection control, and vital-sign monitoring. To monitor the locations of residents and staff, Bluetooth tags were used, providing real-time data for location tracking. We then conduct a series of quantitative analyses to illustrate how indoor tracking data can support the management of nursing homes, including characterizing residents’ activities in daily living and assessing the performance and workload of nursing assistants. Finally, we use qualitative research to evaluate the acceptability of an indoor positioning system in the nursing home. The results show that the implemented indoor positioning applications can improve the quality of healthcare and working efficiency, thereby providing a safer and more secure living environment for residents.