bluuebunny/crossref_metadata_2025 huggingface dataset:
O debate sobre asserção
Authors: Santos Daniel Ramos dos
Published: February 2024

Esse artigo tem como objetivo fazer uma apresentação introdutória do debate sobre asserção. Para tanto, em um primeiro momento, farei uma breve visita às clássicas teorias dos atos de fala, mostrando a asserção como um tipo de ato de fala. Em seguida, mostrarei as variadas tentativas, em filosofia da linguagem e epistemologia, de encontrar os elementos definidores da asserção e as quatro teorias mais destacadas sobre asserção.
Validad (Geltung) y evaluación - Sobre el lugar de Lotze en el Psychologismusstreit
Authors: Porta Mario Ariel Gonzales
Published: February 2024

Existe de Herbart a Husserl una evolución en el antipsicologismo en el sentido de ofrecer una concepción de subjetividad acorde con el mismo. Lotze constituye un momento intermedio en este proceso, en cuanto, por un lado, contra Herbart, da un paso decisivo para superar la idea naturalista de subjetividad, por otro, sin embargo, mantiene con Herbart la validez irrestricta del principio de inmanencia, principio éste que será objeto de la expresa crítica de Frege y Husserl. En este último, como es sabido, la superación definitiva del psicologismo se consuma como superación definitiva del naturalismo.
Knowledge and Self-Knowledge
Authors: Stival Stefano Domingues
Published: February 2024

This text will be generated by contraposition (in the broadest sense) of two concepts, which I will call “externalist conception of knowledge”, on one side, and “internalist conception of knowledge” (as a kind of psychologist evidentialism), on the other. Through this contrast, I try to reach some new insights into the relationship between the notions of “knowledge” and “self-knowledge”.
An Idea Evaluation Phase in Online Communities: A Case on the COVID-19 Innovation Platform
Authors: Çubukcu Ahmet , Akarçay Pervin Özlem , Boz Esra , Çalık Ahmet
Published: February 2024

The COVID-19 pandemic has not only created public health issues but also sectoral problems and economic crises. As a response to this unexpected phenomenon, online communities have also started initiatives to tackle it. One of these initiatives was carried out in Turkey. Innovative project ideas were gathered from entrepreneurs and potential contributors regarding the problems brought about by the COVID-19 pandemic. The program occurred over three months (April 2020 to June 2020) through an open innovation platform in Turkey. The scope of this program is to collect business ideas from entrepreneurs and potential contributors, mature ideas with mentors and other entrepreneurs, and select the best ones by jury. In the process of evaluating the ideas, the weighted sum method (WSM) was used by the jury. The main purpose of this study is to reveal the effectiveness of the WSM via online communities in the idea evaluation phase. To demonstrate how this, we implemented different multi-criterion decision-making (MCDM) methods to the decision matrix dataset. We compare the results of WSM to those of the other two well-known (TOPSIS and VIKOR) MCDM methods. Besides, we conducted regression and sensitivity analysis to further clarify the differences between the results. Thereafter, we combine the rankings obtained from three MCDM methods by applying three aggregation methods as a compromise solution for the final decision. We find that the decision-makers can use WSM, TOPSIS, VIKOR, and aggregation methods separately according to the criterion weighting and the level of confidence in the scoring of the alternatives.
HUQUQIY EKSPERIMENTNI O‘TKAZISH BOSQICHLARI: NAZARIY-HUQUQIY TAHLIL
Authors:   Tashkent State University of Law, Khayitov Sherzod
Published: February 2024

This article analyzes the concept of legal experiment, its types and classification, as well as the stages of legal experiment on the basis of national and foreign experience. In particular, it is proposed to prepare and conduct a legal experiment in three stages, while the range of subjects responsible for conducting a legal experiment is covered within the framework of national legislation. It was noted that conducting a legal experiment has a positive effect on the relevant area of public policy and reform, but some problems have also been identified that impede the use of a legal experiment. In the definition of a legal experiment, the main characteristics important for evaluating its effectiveness and efficiency are highlighted. The importance of the legal experiment is substantiated since each of its stages is characterized by the fulfillment of certain tasks involving the implementation of specific actions and the consolidation of their results in procedural documents. The peculiarity of the legal experiment is that it is aimed at a specially developed goal, which consists in testing one or another legal hypothesis in an artificially created environment and determining the active role of the subject of the experiment in the development of social relations.
"KONSTITUTSIONALIZMNING PAYDO BO‘LISHI VA UNING RIVOJLANISH ASOSLARI "
Authors:   Law College of Kashkadarya Region, Amirov Sanjar
Published: February 2024

"In this article, the classic theories and classical concepts of constitutionalism, as well as the characteristics and practice of constitutional government in the whole world, are considered from a scientific theoretical point of view. Also, the role of constitutionalism in the historical process of the countries of the world up to the stage of achieving democratic freedoms and the fact that it was the basic concept in the organization of state power are studied. In today’s globalized world, we can understand that constitutionalism is the foundation and basis of any developed country from the point of view of the organization of the state and law. It is revealed that constitutionalism played an extremely important role in the gradual development of humanity and in the emergence of basic human rights and freedoms based on the basic concepts and approaches of ancient philosophers. The traditions of constitutionalism in the creation of the state and law, which is one of the most urgent problems of today, and its organization and main concept in this process, are based on deep thoughts and scientific considerations. When familiarizing myself with the article, the proportion of constitutionalism and similar theories created by the human mind in the transition to the democratic society it dreamed of from the beginning of humanity to the present day has been scientifically compared and studied. Based on the concepts of person, state, and society and their rights and obligations before the constitution and the law, the most ideal form of these three subjects is the basis of constitutionalism. It is interpreted through existing theories and methods. "
Simulating net ecosystem exchange under seasonal snow cover at an Arctic tundra site
Authors: Dutch Victoria R. , Rutter Nick , Wake Leanne , Sonnentag Oliver , Hould Gosselin Gabriel , Sandells Melody , Derksen Chris , Walker Branden , Meyer Gesa , Essery Richard , Kelly Richard , Marsh Phillip , Boike Julia , Detto Matteo
Published: February 2024

Abstract. Estimates of winter (snow-covered non-growing season) CO2 fluxes across the Arctic region vary by a factor of 3.5, with considerable variation between measured and simulated fluxes. Measurements of snow properties, soil temperatures, and net ecosystem exchange (NEE) at Trail Valley Creek, NWT, Canada, allowed for the evaluation of simulated winter NEE in a tundra environment with the Community Land Model (CLM5.0). Default CLM5.0 parameterisations did not adequately simulate winter NEE in this tundra environment, with near-zero NEE (< 0.01 gCm-2d-1) simulated between November and mid-May. In contrast, measured NEE was broadly positive (indicating net CO2 release) from snow-cover onset until late April. Changes to the parameterisation of snow thermal conductivity, required to correct for a cold soil temperature bias, reduced the duration for which no NEE was simulated. Parameter sensitivity analysis revealed the critical role of the minimum soil moisture threshold of decomposition (Ψmin) in regulating winter soil respiration. The default value of this parameter (Ψmin) was too high, preventing simulation of soil respiration for the vast majority of the snow-covered season. In addition, the default rate of change of soil respiration with temperature (Q10) was too low, further contributing to poor model performance during winter. As Ψmin and Q10 had opposing effects on the magnitude of simulated winter soil respiration, larger negative values of Ψmin and larger positive values of Q10 are required to simulate wintertime NEE more adequately.
Bayesian Cloud Top Phase Determination for Meteosat Second Generation
Authors: Mayer Johanna , Bugliaro Luca , Mayer Bernhard , Piontek Dennis , Voigt Christiane
Published: February 2024

Abstract. A comprehensive understanding of cloud thermodynamic phase is crucial for assessing the cloud radiative effect and is a prerequisite for remote sensing retrievals of microphysical cloud properties. While previous algorithms mainly distinguished between ice and liquid phases, there is now a growing awareness for the need to further distinguish between warm liquid, supercooled and mixed phase clouds. To address this need, we introduce a novel method named ProPS, which enables cloud detection and determination of cloud top phase using SEVIRI, the geostationary passive imager aboard Meteosat Second Generation. ProPS discriminates between clear sky, optically thin ice (TI), optically thick ice (IC), mixed phase (MP), supercooled liquid (SC), and warm liquid (LQ) clouds. Our method uses a Bayesian approach based on the cloud mask and cloud phase from the lidar-radar cloud product DARDAR. Validation of ProPS using six months of independent DARDAR data shows promising results: The daytime algorithm successfully detects 93 % of clouds and 86 % of clear sky pixels. In addition, for phase determination, ProPS accurately classifies 91 % of IC, 78 % of TI, 52 % of MP, 58 % of SC and 86 % of LQ, providing a significant improvement in accurate cloud top phase discrimination compared to traditional retrieval methods.
Channel cross-section heterogeneity of particulate organic carbon transport in the Huanghe
Authors: Ke Yutian , Calmels Damien , Bouchez Julien , Massault Marc , Chetelat Benjamin , Noret Aurélie , Cai Hongming , Chen Jiubin , Gaillardet Jérôme , Quantin Cécile
Published: February 2024

Abstract. The Huanghe (Yellow River), one of the largest turbid river systems in the world, has long been recognized as a major contributor of suspended particulate matter (SPM) to the ocean. However, over the last few decades, the SPM export flux of the Huanghe has decreased over 90 % due to the high management, impacting the global export of particulate organic carbon (POC). To better constrain sources and modes of transport of POC beyond the previously investigated transportation of POC near the channel surface, SPM samples were for the first time collected over a whole channel cross-section in the lower Huanghe. Riverine SPM samples were analyzed for particle size and major element contents, as well as for POC content and dual carbon isotopes (13C and 14C). Clear vertical and lateral heterogeneities of the physical and chemical properties of SPM are observed within the river cross-section. For instance, finer SPM carry more POC in general with higher 14C activity near the surface of the right bank. Notably, we discuss how bank erosion in the alluvial plain is likely to generate lateral heterogeneity in POC composition. The Huanghe POC is millennial-aged (4020 ± 500 radiocarbon years) and dominated by organic carbon (OC) from the biosphere, while the lithospheric fraction is ca. 12 %. The mobilization of aged and refractory OC, including radiocarbon-dead biospheric OC, from deeper soil horizons of the loess–paleosol sequence through erosion in the Chinese Loess Plateau is an important mechanism contributing to fluvial POC in the Huanghe drainage basin. Altogether, anthropogenic activities can drastically change the compositions and transport dynamics of fluvial POC, consequentially altering the feedback of the source-to-sink trajectory of a river system to regional and global carbon cycles.
TOWARDS MASTER DATA MANAGEMENT FOR CULTURAL HERITAGE: THE SACRI MONTI WEB PLATFORM
Authors: Spettu F. , Parri S. , Quaroni P. , Achille C. , Fassi F.
Published: February 2024

Abstract. This paper focuses on managing the Cultural Heritage maintenance process through web platforms, exploring a data-driven new approach that relies on the framework of Master Data Management (MDM). The MDM framework is based on data quality, revisioning and auditing of information, and the Microsoft SQL Server Master Data Services (MDS) was used. It is a highly customizable commercial tool that proved to be effective and able to manage extended and articulated databases and provide stability and long-term software support. MDS provides powerful tools to avoid duplicates, ensure data quality, and record all the modifications that occurred on the dataset over time. These are key features to build a reliable platform for information management of complex CH assets.The paper presents some first tests applied for the Sacri Monti of Piedmont and Lombardy case of study. It is a UNESCO wide religious architectural complex site in northern Italy’s mountainous part. The paper compares approaches and previous experiences of Sacri Monti management using web platform information systems, such as the BIM3DSG, Chimera, and Main10ance, to support Sacri Monti management activity.
AN INNOVATIVE APPROACH FOR THE SEMANTIC SEGMENTATION OF SURVEYED BUILDING FACADES LEVERAGING ON ARCHITECTURAL DRAWINGS
Authors: Trivi M. B. , Mazzacca G. , Griffo M. , Malek S. , Battisti R. , Remondino F. , Bianchini C. , Chiavoni E.
Published: February 2024

Abstract. Traditionally, drawing products created from 3D surveying activities have been the universal medium of communication used by architects. This has resulted in a vast repository of graphic documentation that serves as a testament of the architectural heritage. The embedded information found in elevations, plans and sections holds considerable value, and it can be seamlessly integrated into the intricate graphics produced during large-scale data acquisition processes. The core objective of this research is to investigate how the information coming from the large amount of existing architectural technical drawings can support 3D heritage classification processes and avoid time-consuming annotation of materials and construction techniques of historical building facades. Starting from available sets of drawings, AI-based methodologies are applied for the annotation of orthoimages and point clouds in order to obtain a predictive model that can recognize classes of materials and construction techniques in a large amount of data. The predicted classes also allow the automatic creation of vector drawing representing the facades of new buildings, providing a novel tool to facilitate the processes of analysis and conservation of architectural heritage.
ACCURATE 3D MODEL OF VENICE: PRESERVING HISTORICAL DATA AND INTRODUCING SLAM IMMS FOR CHANGE DETECTION AND UPDATING PROCEDURES
Authors: Vassena G. P. M. , Fellin A. , Mainardi A. , Perfetti L. , Cavallari L. , Sgrenzaroli M. , Roggeri S. , Fassi F.
Published: February 2024

Abstract. The Municipality of Venice, through Insula srl (Insula, 2024), started the RAMSES (Rilievo Altimetrico, Modellazione Spaziale E Scansione 3D) project in 2005 with the unprecedented intention of conducting a static laser scanner survey of an entire city. The authors of this paper, who have been involved in the project on behalf of the client, including drafting general contract technical specifications, wished to revisit the survey’s findings nearly two decades later. This contribution illustrates the procedures implemented to guarantee the future accessibility of the surveyed data. It is interesting to highlight how the detailed technical specifications outlined in the general technical contract section have facilitated the retrieval of the historical three-dimensional laser scanner measurements archive. Tests have been conducted to determine how the existing mobile mapping technologies may be utilised to update the three-dimensional historical data obtained in the Ramses project efficiently. Furthermore, the paper describes the surveying approach that has never been adequately described in the literature. The surveying and geo-referencing methodologies continue to have several interesting and relevant aspects, especially regarding how the topographic network has been implemented. The Ramses three-dimensional model represents an extraordinary, valuable digital archive containing portraits of the city’s conditions at the time of the mapping. Ramses 3D model, when enriched with field activities conducted using more updated technologies, can provide interesting and unique evaluations of the evolution of Venice’s landscape.
Assessing LISFLOOD-FP with the next-generation digital elevation model FABDEM using household survey and remote sensing data in the Central Highlands of Vietnam
Authors: Hawker Laurence , Neal Jeffrey , Savage James , Kirkpatrick Thomas , Lord Rachel , Zylberberg Yanos , Groeger Andre , Thuy Truong Dang , Fox Sean , Agyemang Felix , Nam Pham Khanh
Published: February 2024

Abstract. Flooding is an endemic global challenge with annual damages totalling billions of dollars. Impacts are felt most acutely in low- and middle-income countries, where rapid demographic change is driving increased exposure. These areas also tend to lack high-precision hazard mapping data with which to better understand or manage risk. To address this information gap a number of global flood models have been developed in recent years. However, there is substantial uncertainty over the performance of these data products. Arguably the most important component of a global flood model is the digital elevation model (DEM), which must represent the terrain without surface artifacts such as forests and buildings. Here we develop and evaluate a next generation of global hydrodynamic flood model based on the recently released FABDEM DEM. We evaluate the model and compare it to a previous version using the MERIT DEM at three study sites in the Central Highlands of Vietnam using two independent validation data sets based on a household survey and remotely sensed observations of recent flooding. The global flood model based on FABDEM consistently outperformed a model based on MERIT, and the agreement between the model and remote sensing was greater than the agreement between the two validation data sets.
Performance Analysis of Five U-Nets on Cervical Cancer Datasets
Authors: Chatterjee Priyadarshini , Siddiqui Shadab , Granata Giuseppe , Dey Prasanjit , Abdul Kareem Razia Sulthana
Published: February 2024

Image segmentation is crucial for precise analysis and classification of biomedical images, especially in the realm of cervical cancer detection. The accuracy of segmentation significantly influences the efficacy of subsequent image classification processes. While traditional algorithms exist for image segmentation, recent advancements in convolutional neural networks, particularly U-Nets have showcased exceptional effectiveness, especially in the realm of biomedical imaging. This research focuses on evaluating the accuracy of various U-Net architectures applied to three distinct cervical cancer datasets i.e., DSB containing 1340 images, SipakMed containing 1849 images and Intel Images for Screening containing 2000 images datasets taken from 2018 Data Science Bowl. The investigated U-Net architectures comprise the fundamental U-Net, Attention U-Net, Double U-Net, Spatial Attention U-Net, and Residual U-Net. The performance of the u-nets is judged on the metrics: Recall, Precision, F1, Jaccard and Accuracy. It is observed that Basic U-Net on the DSB dataset provides highest value on these metrices and accuracy obtained is 96%. The reason of high accuracy for DSB dataset can be attributed to the contrast of the images which by using co-occurrence matrix is calculated as 145.
La configuración de códigos de comunicación en la literatura y en la sociedad del siglo XVIII desde los ideales ilustrados
Authors: Martínez Navarro María del Rosario
Published: February 2024

En este trabajo se aborda la comunicación sociocultural a partir de distintos textos literarios y otros testimonios no literarios y audiovisuales relativos al siglo XVIII. Cobran especial atención las epístolas, los grabados, los lunares, el lenguaje del abanico, el galanteo o la danza cortesana. La mayoría de estas manifestaciones ofrecen un marcado protagonismo femenino, ya que algunas aristócratas actúan como verdaderas influencers de su tiempo. Mediante un enfoque interdisciplinar, se realiza un recorrido por estas manifestaciones —también como maneras y referentes esenciales de protocolo y cortesía del espacio áulico— en la literatura, la historia y en otras artes y ámbitos ilustrados (pintura, baile y costumbres), así como en la literatura, la moda o el cine contemporáneos. Se complementa la visión del funcionamiento de la sociedad dieciochesca en el contexto europeo y americano bajo una mirada actual, especialmente en el séptimo arte, donde en los últimos años está despertando mayor interés.
Storia di un “nobilissimo capitano”: l’humanitas di Zenobia nelle riscritture di Cornelio Lanci
Authors: Di Cosmo Mariasole
Published: February 2024

Cornelio Lanci si avvale di sei trattati degli Esempi della virtù delle donne per testimoniare l’humanitas ante litteram di Zenobia, sovrana dell’impero d’Oriente ai tempi di Aureliano. L’articolo si propone di indagare le possibili fonti cui l’urbinate attinse per approntare le sue personali riscritture delle gloriose imprese della regina dei Palmireni.
Saúde Única: Onde a Medicina Humana, a Medicina Veterinária e asCiências Ambientaisse Encontram
Authors: Cristina Schneider Maria , Sciancalepore Sofia , Polo Noemi , I. Galan Deise , Santini de Oliveira Marilia
Published: February 2024

Nesses últimos vinte anos, cresceu mui¬to a importância de entendermos que esta¬mos todos conectados neste planeta, tam¬bém com os animais, e compartilhamos um ecossistema. Esta ideia é destacada pela abor¬dagem de Saúde Única. Existem várias defi¬nições de Saúde Única (One Health), entre elas a elaborada pelo Painel de Especialistas de Alto Nível em One Health (acrônimo em inglês: OHHLEP). Poderíamos sugerir que alguns aspectos estão presentes na maioria das definições, entre eles a importância da colaboração de diferentes disciplinas e seto¬res para se alcançar a saúde das pessoas, dos animais e dos ecossistemas, não apenas dos humanos.
دور عناصر الحوكمة في ترشيد القرارات الاستثمارية (دراسة ميدانية على الإدارة العامة للاستثمار والتخصيص في وزارة التعليم)
Authors:   ماجستير حوكمة وسياسات عامة، كلية إدارة الأعمال، جامعة الملك سعود، المملكة العربية السعودية, الهاجري نوال
Published: February 2024

في ظل رؤية المملكة 2030، تبدو الحاجة الملحة لتطوير منظومة التعليم ومؤسساته، باعتباره أحد المجالات التنموية لإسهاماته المتعددة في التنمية، حيث يعد قطاع التعليم في المملكة من أبرز القطاعات التي تتقاطع وتتعاون مع جميع القطاعات الاستثمارية الأخرى، ومن هذا المنطلق هدف البحث الحالي إلى التعرف على دور عناصر الحوكمة في ترشيد القرارات الاستثمارية لأصول وزارة التعليم والشراكة مع القطاع الخاص من وجهة نظر قادة الإدارة العامة للاستثمار والتخصيص بوزارة التعليم لضمان مصادر تمويلية مستدامة وبناء الشراكات وزيادة مساهمة القطاع الخاص، والاستثمار في رأس المال المادي والبشري لدعم المشاريع التعليمية وتنويع مصادر التمويل بالوزارة، واستخدمت الباحثة أداة المقابلة لجمع المعلومات بالاعتماد على المنهج الوصفي المسحي، وقد توصلت الباحثة من خلال البحث الميداني إلى أن الإدارة العامة للاستثمار والتخصيص تطبق عناصر الحوكمة لاتخاذ أي قرار استثماري؛ إلا إنه لا يساهم بشكل كبير في ترشيد القرارات الاستثمارية؛ نتيجة لافتقار الإدارة العامة للاستثمار والتخصيص خطة استراتيجية والتي تؤثر سلباً على مستوى تطبيق عناصر الحوكمة في ترشيد القرارات الاستثمارية، كما يوصي البحث بضرورة وضع خطة استراتيجية للإدارة العامة للاستثمار والتخصيص؛ لعلاقته المباشرة بمستوى تطبيق عناصر الحوكمة في ترشيد القرارات الاستثمارية وتحديد موارد وقدرات وزارة التعليم مما يسمح لها باختيار أفضل الاستثمارات، كما يوصي أيضاً بإنشاء إدارة تختص بالحوكمة والسياسات العامة بوزارة التعليم لتعزيز مخرجات وزارة التعليم للمساهمة في التنمية الشاملة والمستدامة.
Awareness and knowledge regarding dental radiology: A cross-sectional study
Authors: Akbar Zainab , Butt Sabeen Saeed , Waris Sana , Junaid Syed Muhammad , Javaid Sanya
Published: February 2024

Introduction: Dental radiographs are an important tool for the diagnostic workup of the patient. Both basic and specialized radiographs are used in dentistry and knowledge regarding its indications and techniques is required both for undergraduate and postgraduate students, general dentists, and consultants.

Objective: Our study aimed to explore the knowledge and awareness of dental radiographs among dentists and dental students.

Materials and method: The cross-sectional descriptive study was conducted at Rehman College of Dentistry, Peshawar Pakistan from October 2022 to March 2023. The questionnaire was prepared after a literature review, validation by experts, and pilot testing. Reliability was observed to be more than 0.9 and the questionnaire was disseminated through online Google forms using convenience sampling. SPSS Version 22.0 was used for data analysis.

Results:  154 Participants were included in the study. Out of which 58 percent were females and 42 percent were males. Generally,  regarding most of the questions, specialists had the highest knowledge, while postgraduate and general dentists had a neutral ratio, and undergraduates were the least aware.

Conclusion: Despite the utmost significance of dental radiology in the diagnosis and treatment planning of the patient, it is not given its due importance. Generally, the dental fraternity lags in knowledge and awareness about the field, especially at the undergraduate level.
Tuberculosis: past and present
Authors: Ivanes Igor , Ustian Aurelia , Iavorschi Constantin
Published: February 2024

Tuberculosis is a serious infectious disease with a global impact, causing a significant number of deaths each year. It continues to pose a major challenge to the healthcare system and requires sustained efforts for control and prevention. The aim of this study was to analyze the historical aspects of tuberculosis and the outcomes of global and local control programs. The materials and methods involved research of specialized literature. The main conclusions include the historical evolution of tuberculosis, the impact of discoveries and medical advancements on its treatment and control, as well as the ongoing need to implement effective prevention and treatment strategies.
Post-COVID-19 pulmonary damage in infants
Authors: Conica Corina , Selevestru Rodica , Sciuca Svetlana
Published: February 2024

COVID-19 infection affects any age and gender. Among the pediatric population, the most vulnerable are children up to 3-5 years old. Infants are especially affected, they present the most complications following post-COVID19 lung damage. The article presents the case of an infant who suffered severe SARS-CoV-2 infection. With the help of high-precision imaging investigations, such as Computed Tomography, it was possible to detect the bronchopulmonary changes that occurred after enduring the infection.
Spontaneous heterotopic pregnancy
Authors: Mishina Anna , Puiu Serghei , Dobreva Cristina
Published: February 2024

The authors presented a documented case of spontaneous heterotopic pregnancy (uterine in combination with ruptured left tubal pregnancy). A laparoscopic tubectomy was performed. The uterine pregnancy progressed and finalized in time with the birth of a healthy child through the natural genital tract. A review of the literature on the diagnostic features and surgical treatment of heterotopic pregnancy is presented.
Ovarian Brenner tumor
Authors: Mishina Anna , Gladun Sergiu , Sinitina Lilia
Published: February 2024

The authors presents a clinical observation of a rare pathology - Brenner’s tumor of the ovary. A narrative review of the literature on the diagnosis and treatment of this pathology is given.
Reverse Phase Liquid Chromatography for Cetrimide Determination in Pure and Pharmaceutical Preparations
Authors: T I Alkayar Ziad , A.Ismail Ahmed , Jassim Al-Ani Nagham Muthanna , Anastasia Alekseevna Fedoseenko , Mahdi Saeed Ahmed , Nasser Al-Amir Haider Mahmoud , Shakoori Yaseen Mahmood , Mohammed Tawfiq Bashaar , M. Jassem Zena , Ahmad Hassan Shaimaa , O. Abd Ala Maryam
Published: February 2024

An effective, duplicable, and quick method to determine the purity and formulating form of Cetrimide (CE) have studied and modified utilizing the Reverse Phase High Performance Liquid Chromatography (RP-HPLC). The method was based on the separation of the CE using a reverse phase HPLC Shimadzu LC–20 A, Japan, and Phenomenex C18 column (15 × 4.6mm, 5.0μm). The process was carried out by using the mobile phase ammonium acetate solution 0.1M (AA), methanol (MeOH), and the methyl cyanide in the ratio of (15:60:25 V/V/V), a flow rate of 1.0mL/min, at pH = 3, with 10μL sample loop and the UV - spectrophotometry detector was set at 280nm. However, for the optimum conditions the mobile phase composition, wavelength, pH, and flow rate were studied. The calibration carve has obtained in the range of 10-1000mg/L and the correlation coefficient is 0.9985. The average recovery of the standard drug was 97.56%. The LOD was 5mg/L and LOQ is 16.5mg/L for CE. The process was used successfully to determine the CE in the pharmaceutical forms with the average recovery of 95.61 and 96.02%.
Determination of the Anti-bacterial potency of Allium sativum (Garlic) extract against Agrobacterium tumefaciens causing Crown Gall Disease
Authors: Hemaa S. , Sankarganesh P. , Parthasarathy V. , Anbarasan R.
Published: February 2024

The isolated crown galls (a bacterial plant disease) from Pongamia pinnata leaf were investigated to identify the causative agent. The SEM analysis revealed that the causative agent in crown gall appeared to be a slender, pink and rod-shaped bacterium. The morphological, cultural, biochemical and tumorogenesis analyses were performed to identify causative organisms in the crown gall disease. The isolate was negative for Indole, MR and VP tests, but positive for Citrate, TSI, Urease, Catalase and Oxidase tests. The causative organism also developed a tumor-like sport during the potato disc assay after 3rd week of incubation. The causative agent in crown gall was identified as Agrobacterium tumefaciens. The ethanolic extract of Allium sativum produced an inhibitory zone of 15 mm against this isolate. The current study proved that ethanolic extract of garlic can be effectively used to treat crown gall disease in the economically valuable dicot plant of Pongamia pinnata.
Investigation of Oil in Water Emulsion properties depending on the change of Emulsifiers combinations
Authors: Polova Zhanna , Nehoda Tetiana , Butkevych Tetiana
Published: February 2024

Oil in water emulsion formulations as dosage forms for topical application are intended to produce the therapeutic effect in the skin. Their quality features mainly depend on the choice of emulsifying combination composition. This work aimed at establishing a mixture of oil phase, water and combinations of different kinds of emulsifiers to screen factors that affect the quality features of oil in water emulsion cream`s formulations. Eleven formulations were prepared with different ratio of different kinds of emulsifiers by a high temperature method. The emulsions were prepared with oil phase having calculated HLB value range 10.96 and emulsifiers having HLB values ranged from 0.20 to 14.60. The formulated oil in water emulsion compositions were evaluated for physical stability, rheological properties, colloidal and thermodynamic stability, microscopy observation. The results showed that not all formulations were physically stable after 24h storage period. Stable formulations were subjected to rheological properties studies. Some of samples presented the flow which was close to the Newtonian fluid, others showed pseudo-plastic flow type. The results of colloidal and thermodynamic stability evaluations allowed to establish the regularities between the type of the flow and formulations` stability. When varying the ratio of emulsifiers, the total HLB range of the mixture changed, which also affected the dispersion properties of emulsion systems. With certain ratios of emulsifiers the dispersion of the system increased.
Development and Validation of a New HPLC Method for the Estimation of Sulfamoxole in Bulk and Tablet Formulations
Authors: Karuna Moparthy Kamala , Nadh Ratnakaram Venkata , Prasad Gorumutchu Giri
Published: February 2024

To quantify the sulfamoxole content in bulk as well as tablet formulation, a new isocratic RP-HPLC method was developed and then validated. Kromasil C18 column with a dimension of 250 X 4.6mm was used which was filled with a particle size of 5μ. A mixture containing CH3OH, CH3CN and H2O in the volume ratio of 55, 30 and 15 was used as a mobile phase at room temperature with an optimized flow rate of 1ml/min. UV detector was set at 241nm for sulfamoxole determination. The run time of the current method is ten minutes. Accomplished the forced degradation studies to understand the stability indicating nature of the current method. As per the current ICH guides (Q2R1), validation of the method was conducted.
Standardization of Hibiscus rosa-sinensis Flower by HPTLC, HPLC and AAS
Authors: Chakraborty Arpan , Bhattacharjee Arka , Chakraborty Manas , Mukhopadhyay Goutam
Published: February 2024

Hibiscus rosa-sinesis, a well-known flowering plant in India, is used to worship Lord Ganesha. It is a member of the Malvaceae family. It is used in traditional medicine in many tropical countries to treat wounds, inflammation, fever, diabetes, infections, hair loss, and gastric ulcers. Therapeutic benefits of Hibiscus rosa-sinesis are attributed to flavonoids, tannins, terpenoids, saponins, and alkaloids. Hibiscus rosa-sinesis flowers are a good source of flavonoids, which are important components of herbal and Ayurvedic preparations. The goal of this study was to standardize the flower extract through qualitative phytochemical screening and quantitative HPTLC analysis of quercetin, an active biomarker. The result of the HPTLC analysis was compared to those obtained using HPLC. HPTLC found that the extract contained 0.33% quercetin, while HPLC found that it contained 0.37% quercetin. Further, heavy metals and trace elements were measured using atomic absorption spectroscopy (AAS). Results showed that cadmium, lead, arsenic, copper, chromium, and mercury levels (in ppm±SEM) were within acceptable limits: cadmium (0.018±0.050), lead (0.630±0.025), arsenic (0.041±0.014), copper (2.605±0.045), chromium (0.450±0.025), and mercury (0.023±0.006). This method allows standardization of plant material for raw material and finished product testing, ensuring better efficacy and safety.
Effect of Tempuyung (Sonchus arvensis L.) Leaf Extract on Kidney Histology of Mice Exposed to Plasmodium berghei
Authors: Kusuma Wahyuni Dwi , Putra Pradana Rizal Adistya , Astuti Wahyuningsih Sri Puji , Purnobasuki Hery , Pramudya Manikya , Prasongsuk Sehanat , Wacharasindhu Sumrit , Gafar Atere Tope
Published: February 2024

Plasmodium berghei is a parasite that causes complications or damage to the kidneys with elevated values of blood urea nitrogen (BUN) and creatinine in the blood. Tempuyung (Sonchus arvensis L.) leaf extract contains antioxidant compounds in the form of flavonoids which has the potential to reverse kidney damage. This study aimed to determine the effect of various doses of tempuyung leaf extract on kidney histology in mice exposed to Plasmodium berghei. This study used a completely randomized design method with 28 male BALB/c mice aged 6-8 weeks. They were divided into 7 treatment groups, namely KN (Normal Control), K+ (received 10mg/kg BW (bodyweight) of chloroquine diphosphate solution), K- (infected with P. berghei only), P1 (received 1 mg/kg BW of S. arvensis), P2 (10mg/kg BW of S. arvensis), P3 (received S. arvensis 100mg/kg BW), P4 (received S. arvensis 200mg/kg BW). Except in KN treatment group, all other treatment groups were infected with P. berghei .prior to oral administration of S. arvensis. The S. arvensis treatment was carried out for 7 days after which the blood serum was taken intracardially, and the kidneys were removed for histological studies. The results showed that tempuyung leaf extract had a significant effect on the repair of glomerular cells that experienced hydropic degeneration and necrosis but has no significant effect on glomerular atrophy. Thus, tempuyung leaves have the potential to reverse kidney complications caused by malaria.
Prediction of In-silico ADMET Properties and Molecular docking study of Substituted Thiadiazole for screening of Antiviral activity against protein target Covid-19 main protease
Authors: Nitin Deshmukh , Love Kumar Soni
Published: February 2024

The SARS-CoV-2 virus is the infectious disease known as coronavirus disease (COVID-19). The majority of COVID-19 patients will have mild to moderate symptoms and recover without additional care. However, some people will get serious illnesses and need medical attention. Designing novel medications and testing them for inhibitory action against the corona virus's primary targets could be a successful technique for the advancement of the drug discovery process and the treatment of corona virus disease in the context of the COVID-19 pandemic, which is spreading quickly. The objective of this work was to evaluate the physical-chemical, pharmacokinetic parameters (absorption, distribution, metabolism, excretion and toxicity) and pharmacodynamic parameters (bioactivity and adverse reactions) of Substituted thiadiazole by means of in-silico computational prediction. Online software such as Pre-ADMET, Molinspiration and Rule of Five were used for the analysis. In-silico results allow us to conclude that substituted thiadiazole is predicted to be a potential future drug candidate, due to its relevant Drug-likeness profile, bioavailability, excellent liposolubility and adequate pharmacokinetics, including at the level of CNS, penetrating the blood-brain barrier. Molecular docking studies of 20 designed compounds have also been performed to screen the inhibitory activity towards against protein target COVID-19 main protease (PDB: 6LU7). Among all the compounds C3 exhibited the most significant affinity score against COVID-19 main protease (PDB: 6LU7) and Shown best significant hydrogen bonds interaction at the active site of protein.
RISK FACTORS ASSOCIATED WITH IN-HOSPITAL MORTALITY IN PATIENT WITH SEVERE COVID-19 INFECTION
Authors:   Department of Propaedeutics of Internal Diseases, UMHAT ", Pancheva Ralitsa ,   Alexandrovska",   , Medical Faculty, Medical University – Sofia, Bulgaria., Pencheva Ventsislava ,   Department of Propaedeutics of Internal Diseases, UMHAT "Alexandrovska", Medical Faculty, Medical University – Sofia, Bulgaria., Manov Emil ,   Department of Propaedeutics of Internal Diseases, UMHAT "Alexandrovska", Medical Faculty, Medical University – Sofia, Bulgaria., Stoimenov Blagovest ,   Department of Propaedeutics of Internal Diseases, UMHAT "Alexandrovska", Medical Faculty, Medical University – Sofia, Bulgaria.
Published: February 2024

Background: Coronavirus disease (COVID-19) is a pandemic disease, infecting more than 673 million people. Accurate prediction of the risk of progression of COVID-19 is needed at the time of hospitalization. Material and Methods: A retrospective study was conducted between December, 2020 and December, 2021. A total of 165 patients admitted with severe COVID-19 infection were enrolled. The data were collected from the electronic medical records of Alexandrovska Hospital. Results: The mean age of the patients was 64.6±15, of whom 44.8% were men. The median duration from symptom onset to hospitalization was 8.2 days, and from symptom onset to discharge or death was 24.00 days respectively. In-hospital mortality was 23.3%, and post-discharge one-year mortality was 3.7%. 27 (16.7%) patients received invasive mechanical ventilation, 37 (23%) were admitted to the ICU, and 26 (15.8%) received vasopressors. Common acute complications among inpatients included acute pulmonary embolism (2.6%), acute stroke (0.6%), and minor bleeding (3.7%). 12 patients (7.7%) who survived COVID-19 hospitalization were readmitted for additional treatment of other diseases. Several laboratory markers were linked with increased in-hospital mortality: GFR < 55 ml/min, ferritin > 705 µg/L, PaO2 < 7.93 kPa; SpO2 < 93%, oxygen requirements > 12.5 l/min. Mortality risk was higher in patients having hypertension, coronary artery disease, previous ischemic stroke, valvular heart disease, chronic heart failure and atrial fibrillation. Conclusion: The mortality rate was higher in older patients with cardiovascular comorbidities and reduced renal function. Early recognition of high-risk patients may help to improve care and reduce mortality.
Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
Authors:   University of Buenos Aires (UBA), Marcelo Torcuato de Alvear 2142, Piso 5, Sector A, C1122AAH, Buenos Aires, Argentina., Denninghoff Valeria
Published: February 2024

The S100A7 protein plays an essential role in tumor progression and is found to be overexpressed or deregulated in oral mucosal dysplasia and several cancers. However, its expression in oral lichen planus remains unknown. Early detection of malignancy in lichen is a challenge
Prospective Evaluation of PI-RADS Version 2.1 for Prostate Cancer Detection and Investigation of Multiparametric MRI-derived Markers
Authors: Yilmaz Enis C.
Published: February 2024

In our study, we assessed the Prostate Imaging Reporting and Data System (PI-RADS), version 2.1, which is a continually developing and internationally acknowledged MRI-based scoring system used for evaluating the risk of prostate cancer. Conducted between April 2019 and December 2021, our prospective study focused on biological males with suspected or known prostate cancer, aiming to determine the effectiveness of PI-RADS 2.1 in conjunction with MRI features like lesion size, shape, and volume for detecting clinically significant prostate cancer. Apart from assessing the cancer yield in each PI-RADS category, another aspect of our work was to identify more objective, measurable criteria for lesion shape and volume, moving beyond the subjective parameters currently used in PI-RADS. We discovered that the likelihood of identifying clinically significant prostate cancer increases with higher PI-RADS categories and that quantifiable MRI features, such as lesion volume and measure of roundness, are predictors of significant cancer. Our findings also highlight that merging certain subcategories in PI-RADS might result in unnecessary biopsies. In conclusion, our research suggests that incorporating the objective lesion imaging criteria into patient care, alongside PI-RADS scores, could improve diagnostic accuracy. If validated in further studies, these objective measures could potentially be integrated into future iterations of PI-RADS, offering a more precise and reliable approach to prostate cancer detection and reducing unnecessary interventions.
Propuesta de un producto de turismo oscuro a partir de la memoria del Bronx de la ciudad de Bogotá
Authors: Gutiérrez Hernández David , Moreno Berrío Ana , Rivera Bautista Holman
Published: February 2024

El entorno del Bronx en Bogotá se ha convertido en un destino turístico emergente, actualmente está enfocado hacia un turismo oscuro, con esto se está perdiendo la oportunidad de desarrollar un turismo cultural el cual contribuya a la construcción de la memoria de esta importante área. A su vez, se evidencia la falta de un producto turístico claro, la inconsistencia en la finalidad del nuevo Bronx y la percepción negativa del turismo oscuro en el área. El presente articulo tiene como objetivo analizar el turismo oscuro y cultural en la construcción de la memoria en el entorno del Bronx de la ciudad de Bogotá. Utilizó un enfoque cualitativo, con encuestas virtuales realizadas entre agosto y octubre de 2023. Los resultados evidencian la deficiencia turística del Bronx como destino cultural y artístico, su falta de promoción y la baja participación turística debido a prejuicios erróneos. Para concluir, se propone diseñar un producto turístico que fomente el turismo cultural y la memoria en el entorno del Bronx.
chontaduro
Authors: López Cruz Juan
Published: February 2024

El fruto de la palma de chonta, forma domesticada de la palmera Bactris gasipaes, es conocido popularmente en Latinoamérica y el Caribe como chontaduro, chotaduro, pupuña, pijuayo, pixbae, pejibaye o tembe. No obstante, a pesar de su popularidad y de tratarse un alimento ancestral del continente, es muy poco lo que se ha escrito sobre este en comparación con otros alimentos. Esta investigación propone entonces una aproximación histórica al fruto del chontaduro, a partir de fuentes primarias que corresponden a distintos momentos de los periodos de conquista, colonia y república en Colombia, con el fin de indagar por los imaginarios culturales que se han construido alrededor de este fruto y su consumo.
Between the Lines: Toward a Recontextualized Archaeological Practice through Dialogues between Fieldwork and Archival Research
Authors: Raja Rubina
Published: February 2024

Archival material from archaeological fieldwork contained in private and public collections has long been the object of study within various archaeological contexts. Often, however, such material is used as a backdrop or as anecdotal information and not as a point of departure. In this special issue, contributions focus on a variety of ways in which archival material and other kinds of legacy data can usefully be integrated into or provide the ground for archaeological projects and archaeological research, including preparations of new projects or for gaining a deeper understanding of ongoing projects or past projects. Modern developments, conflicts, wars, and the recent pandemic, have all accentuated the need for the curation of archival material and legacy data to an even higher degree than hitherto suspected and revealed that such material often holds information just as crucial to the project as archaeological raw data directly from the ground.
IMPROVING THE BLASTING TECHNOLOGY AT THE DEVELOPMENT OF NON-HOMOGENEOUS ROCKS IN AN OPEN PIT
Authors: AHARONYAN G.A. , HOVSEPYAN V.G.
Published: February 2024

One of the main indicators that determine the effectiveness of blasting in open pits is the degree of crushing of the blasted mass. It is accepted that with an increase in the mass of the explosive charge by thickening the grid of holes, the quality of crushing the blasted rock mass improves. However, this approach leads to an increase in the amount of drilling work and an increase in the cost of explosives. In its turn, the method leads to an increase in the size of the violation of the natural structure behind the contour of the blasted block, which is the focus of oversized output. It should be noted that with an increase in the amount of explosion energy, it is possible to regulate the degree of crushing of the exploded mass, but only when blasting in an extremely large-block (relatively monolithic) array, and with an increase in the number of explosives, the quality of the explosion partially improves. It has been established that in medium and large-block rocks, the main carrier of the explosion energy is considered to be the heterogeneity of the massif.
The paper proposes a new technology for blasting operations on ledges of heterogeneous, layered structures. The proposed breaking method makes it possible to increase the useful effect of the explosion energy on crushing, reduce the cost of explosives, and obtain the collapse of the exploded mass of the given parameters.