bluuebunny/crossref_metadata_2025 huggingface dataset:
Teacher’s and Students’ Perspectives Regarding the Reading Materials in the Extensive Reading and Writing Class
Authors: Suseno Eunike Listyoyanti , Wijaya Henny Putri Saking
Published: October 2021

This qualitative study aimed to know the teacher’s and the students’ perspectives regarding the reading materials in the Extensive Reading and Writing (ERW) class. The study used the theory of Extensive Reading Principles by Day and Bamford (2002). The study also tried to draw the similarities and differences between their perspectives. The subjects of the research were 10 students and 1 teacher from ERW class in the English Department of Petra Christian University, Surabaya. Semi structured interviews were used to explore their perspectives toward the reading materials of ER. The findings showed that the teacher and the students had various perspectives regarding the reading materials in ERW class. In conclusion, the provision of reading material was not really in line with the ER principles because of the unique nature of ERW class. For the future research, the writers suggested doing quantitative research with a variety of subjects for more generalizable result. Keywords: extensive reading, implementation, perspectives, students, teachers
Open Heart: Entering the Dynamic of Polyamorous Relationship.
Authors: Juliandino Lucky , Setiawan Dwi
Published: October 2021

Open Heart is a screenplay under a romantic comedy drama subgenre, which recounts a romantic tale about a monogamous, lonely, single man who is struggling to accept and exercise an open heart during a novel participation in polyamory that the woman he falls for is involved with. In this project, I investigated why my protagonist join a polyamorous courtship and how he handles the common hurdles in consensually non-monogamous (CNM) experiences, specifically, jealousy and stigma-based shame. I answered these problems using findings from polyamory, romantic jealousy and Gregory M. Herek’s sexual stigma concepts. The results determine that my protagonist only agrees to polyamory out of compliance. Also, in order to solve his plights, he needs to uphold particular management for jealousy and shame. Hopefully, by showcasing these issues around non-monogamy and polyamory, I wish my story could promote a wider understanding, along with uncovering the oppression still targeting them. Keywords: Polyamory, consensual non-monogamy, CNM, romantic comedy, romantic jealousy, sexual stigma
Reading Strategies Used in Reading Academic Texts by Students of High and Intermediate Reading Proficiency Levels
Authors: Setiawan Johan , Tjitrakusuma Nani Indrajani
Published: October 2021

In this study, the reading strategies used by students of high and intermediate reading proficiency levels were qualitatively examined. Reading strategies are important factors that affect someone's reading proficiency. In the development of education, reading strategies are continuously carried out to facilitate the learning process and sharpen students' reading skills. The purpose of this study is to discover the reading strategies used by the English Department students with high and intermediate reading proficiency levels in reading academic texts. This study uses reading strategies theory by Grabe (2009) combined with the interview questions by Mokhtari and Reichard (2002) to examine the reading strategies of ten participants consisting of five people with high reading proficiency level and five other people with intermediate reading proficiency level. This study showed that students of high reading proficiency levels tend to use more reading strategies than students with intermediate reading proficiency level. The biggest difference is in the use of text-structure awareness and inferencing strategies. It indicates that the mastery of text structure is directly related to reading effectiveness. Without text structure awareness, other reading strategies such as summarizing, inferencing, and elaborative interrogation will be seriously disrupted. Keywords:  Reading Strategies, Academic Text, High Reading Proficiency Level, Intermediate Reading Proficiency Level
Analysis of Video Traveloka Advertisements Entitled “Dari Monoton Jadi Seru-Seruan” and “Badri and Aldi” Using Multimodal Discourse Theory
Authors: Yohana Yohana , Gunawan Samuel
Published: October 2021

In the marketing world, there are a lot of competitors who compete their business to become the number one. Thus, some companies want to make their product exist in the customer's mind by making a video advertisement which usually appears on television or social media platforms. By making video as the instrument of advertisement, usually some companies can share a particular message about their brand or product to their customer. The message is used to persuade the people who see the advertisement to buy their product. Commonly, the video advertisement contains elements of semiotic resources such as visual, audio, oral, spatial, linguistic, and gesture. Those elements help the audience to understand particular messages. In this thesis, the researcher aims to reflect the message of fun traveling moment in Traveloka video advertisements by looking at the elements of semiotic resources which are divided into two parts, they are verbal and non-verbal expression and find out the brand image of Traveloka video advertisement by looking at interrelatedness of the some semiotic resources. The researcher used two videos of Traveloka advertisements as the object of analysis, then the writer found out the verbal and non-verbal expressions which convey the message using the theories of Multimodal discourse and the writer interpreted the message using a descriptive qualitative research method. According to the researcher's analysis, she finds that both two videos of Traveloka advertisements reflect fun traveling moments which can be seen through the combination of some semiotic resources and find two brand images of Traveloka such as having quality time and seeking meaning of life. Keywords: Advertisement, Verbal, Non Verbal, Semiotic, Traveloka, Multimodal
Children’s Picture Book Series on Exploring Children’s Development of a Balanced Identity
Authors: Rawiadji Charaqua Vania , Limanta Liem Satya
Published: October 2021

This paper elaborates the project of creating picture-book stories for two to five years old of Indonesian children, which highlight the issue of identity development in children. Erik Erikson’s eight stages of psychosocial development will be the theoretical framework of this paper. In the first and second story, the main characters pass through the crisis of autonomy versus shame and doubt. They have strict and overprotective parents that caused them to doubt themselves. However, by believing in themselves and taking an action, they passed the crisis and developed a balanced identity. In the third, fourth, and fifth story, the main characters pass through the crisis of initiative versus guilt. They learn to be honest, to forgive, and to let go. Each action has its own risk, but by taking the initiative to do the right thing, they passed the crisis successfully and formed a balanced identity.Keywords: children picture-books, children development, psychosocial development, autonomy vs shame and doubt, initiative vs guilt, balanced identity
Improving KRN.BGT’s Product Knowledge through the List of FAQs on KRN.BGT’s Instagram Stories Highlights
Authors: Yatdiyanto Elrica Puspitasari
Published: October 2021

Established in April 2020 by Budi Santosa, KRN.BGT is a fashion brand from Jogja Painting that produces artistic masks by collaborating with other local artists. KRN.BGT is targeting people aged 20s-30s who like visual arts. Although it has a well-designed Instagram account, they still receive many questions from their customers and potential customers regarding their products through Instagram direct messages and comments. Therefore, I decided to improve KRN.BGT’s product knowledge by creating a list of FAQs of its products on its Instagram Stories Highlights, compiled from the direct messages and comments by applying the theories of good FAQs by Biroscak (2019) and color contrast from Alscher (2019) and Evans (2019). I found three USPs from my observation and survey, namely adjustable, suitable for adults and children, and customizable; and include them into the list of FAQs, so its existing and potential customers know more about its products. Keywords: product knowledge, FAQ, Instagram, Instagram Stories Highlights
The Strategies of Translation of Bahasa Indonesia-English in Two Indonesia Tourism Websites
Authors: Valerian Eldi
Published: October 2021

This study discusses the use of translation strategies in translating Indonesian culture-bound words in two Indonesia tourism website articles. By using a descriptive qualitative analysis method, the translation strategies found in the Indonesian culture-bound words were observed using the theory from Mona Baker (2018). The rank of the most dominant strategies, from the most frequent to the least, used by both translator teams of Wonderful Indonesia and Enjoy Jakarta are loan word with an explanation, word-for-word, cultural substitution, and general word. In the Indonesia culture-bound translation, the most strategy used the culture-bound words is loan word strategy. It is better because instead of translating the Indonesia culture-bound word, the writer keep the culture-bound word in the english version and explain the meaning of the culture-bound word from explaining the history or the ingredients behind the culture-bound words so the international tourists can know the meaning behind the Indonesia culture-bound words without changing the names. In conclusion, both translator teams mostly used loan word strategy as their main strategy in the English translation, but still used other strategy in certain Indonesia culture-bound words. Keywords: translation, translation strategies, culture-bound words
Slang Language in the Subtitle of “The Social Network” Movie
Authors: Sienatra Kevin
Published: October 2021

Movies are everyday entertainment for people in their daily lives. There are a lot of foreign movies that are being played in Indonesian theatres. Unfortunately, there are many places where people watch the movie with the subtitles that are not created by the professional translators. The Social Network was translated by more than one translator. This research was conducted to analyze how accurate the translation is and what the similarities and differences between the translators are. This study is a qualitative descriptive study, which analyzes the slang word translation accuracy in the movie The Social Network using Newmark theories of translation quality assessment. The finding of the study showed that the translation from both of the translators is accurate enough and there is almost no inaccurate translation, also there are several slang words that are not included in the data of the previous study, but the writer found on subtitle the data of the other two translators. Keywords: Slang, Translation, Accuracy
Speech Styles Used By Bagas as the Main Character in Pakai Hati the Series
Authors: Sosrohartono Nathania Edlyn
Published: October 2021

This study aims to find the speech styles used by Bagas as the main character in Pakai Hati The Series when he talked to his colleagues, clients, and supervisors.  In conducting this study, I used the theory of speech styles by Chaer and Agustina (2010), standard Indonesian characteristics by Prihantini (2015) and Kridalaksana (2007), social dimension by Holmes (2017), and status by Brown and Attardo (2005) as the theoretical framework. This study employed a qualitative approach. From the analysis, I found that Bagas used the consultative style, casual style, and intimate style when talking to his colleagues, clients, and bosses. He also used the formal style towards his clients, but he did not use the frozen style when talking to his interlocutors. This study showed that Bagas did not differentiate his speech style merely based on status since there were some other factors that might affect his choice of speech style, namely: habit or personality, type or context of the conversation, and social distance. Keywords: speech styles, status, web series
Semiotic Analysis of Dove’s Femvertising
Authors: Hojeung Chun , Suprajitno Setefanus
Published: October 2021

This qualitative study aimed to know in what ways the verbal (oral mode) and non-verbal (visual mode and gestural mode) semiotic resources help Dove meet the criteria of femvertising. The study used the Multimodal approach to help analyze the data. The writer collected and analyzed the data from Dove’s My Beauty My Say video. The findings showed that the verbal semiotic resources help Dove meet the criteria of femvertising by orally informing the audiences about the problems and arguments that are faced by the women in the video and how they responded to the problems in order to empower all the women. Meanwhile, the non-verbal semiotic resources help Dove meet the criteria of femvertising by revealing women in the authentic form and outside of traditional gender stereotypes so that they can deliver predominantly pro-female messages that can empower themselves and other women who are facing the similar problems as they do. The non-verbal semiotic resources are delivered by using the gestures (e.g. facial expression and body language) and objects (e.g. outfits, dominated background color, focus of the camera) in the video. In conclusion, I observe these semiotic resources are important to help Dove meet the criteria of femvertising.  Keywords: Femvertising, Multimodal, Verbal semiotic resources, Non-verbal semiotic resources
Expanding the Target Market of Mebel Summer Jati Using an Online Catalogue Shared on Facebook
Authors: Verentino Kelvin
Published: October 2021

Mebel Sumber Jati is an organization that sells furniture items like teak closet, teak table, teak wood seats, spring bed, aluminum glass cabinet, sofa, and eating table. The issue is the deals of this organization continues to decrease since the pandemic occurred. That is the reason behind why this organization actually struggles to get new clients. Nonetheless, the organization intends to grow its objective market, particularly during this pandemic. The arrangement is by extending the objective business sectors through Facebook with an online inventory. On Facebook, the organization will combine the photograph items and the cost just as on the online list. The online catalogue will be distributed on the Facebook marketplace page as a connection. The catalog was made using the theory of Bethina Oksen Bendroff, 2021 Therefore, by having a Facebook with an online list, Mebel Sumber Jati will actually be able to extend their new objective market. Keywords: Facebook, Online catalogue, Expanding target market
Product Placement of Samsung Galaxy Note 5 in “Ariana Grande-Focus” Music Video
Authors: Poela Putra Yunior
Published: October 2021

Product placement is one of popular advertisement methods, which, broadly, compile different purposes from two or more parties into one project then achieve each of parties’ purpose. Samsung is one of many companies that use the method. Samsung launched Samsung Note 5 and advertised it through a music video from Ariana Grande’s song “Focus”. Samsung chose it because by that time Ariana Grande is one of the great musicians that has a lot of fans, where Ariana Grande also launched her new music video of her song. This study has a purpose to identify how both kinds of expressions in the music video, verbal expressions and nonverbal expressions, can collaborate as the union to be used as product placement for an advertisement, in this case is product placement of Samsung Galaxy Note 5 in “Ariana Grande-Focus'' Music Video. The data in this study include the lyrics of the music and the scene capture of the music video. In fact, many aspects and details are important to put in to be elaborated as advertisement, which are divided into two types as well, verbal and nonverbal expressions. At the end it is successfully advertised. Keywords: semiotics, product placement, verbal communication, nonverbal communication, music video, advertisement
Interactional Styles used by Male Characters when Gossiping at Workplace in The Intern Movie
Authors: Liebnis Vannia
Published: October 2021

The writer conducted this study to investigate the interactional styles used by the male characters, Ben Whittaker, Jason, Davis, and Lewis in The Intern movie. This study was done by the writer to find the interactional styles used by the male characters when gossiping at the workplace. In conducting this study, the writer used the theory of interactional style by Holmes (2006) and Baxter (2010). Furthermore, this study used a qualitative approach. The result of this study showed that the male characters, Ben Whittaker, Jason, Davis, and Lewis, used all of feminine interactional style when they were gossiping at the workplace. The male characters used facilitative features to increase other speakers’ participations, to show their supportiveness and other-orienteers by using supportive feedback, collaborative, person/process oriented and affectively oriented, and to avoid conflicts by softening the statements using conciliatory features. However, the male characters, Ben Whittaker, Jason, Davis, and Lewis used only five out of seven features of the masculine interactional style. They used competitive, aggressive interruption, confrontational, and direct features to make them straightforward. The male characters also wanted to be credible toward each other, they tended to use referentially oriented features by giving facts. Therefore, the male characters used both feminine interactional styles and masculine interactional styles based on the aims of the gossiping. Keywords: interactional styles, feminine, masculine, gossip, movie
The Meanings of Fair Skin in Eight Unilever’s Skin-whitening Advertisements in Indonesia
Authors: Gunawan Bella Tysha , Mochtar Jenny
Published: October 2021

Human skin color ranges from the darkest to the lightest. However, the culture and the power of media, especially advertisements, convince all women to embrace fair skin as the idealized self. This study aims to find how fair skin is represented in the selected eight Unilever’s skin-whitening advertisements and how this representation reflects consumerism. In conducting this study, I used the theory of representation and consumerism to find the symbolic meanings of consumerism. The finding showed that there were two meanings that are represented by the skin-whitening advertisements, such as youthfulness and success. In conclusion, those eight skin-whitening products were sold not just as products, but also as their symbolic meanings that lead women to youthfulness and success. Keywords: fair skin, skin-whitening advertisements, meanings, youthfulness, success, consumerism
Unwritten Scars: Gaslighting in Relationships
Authors: Kurniawan Licia , Limanta Liem Satya
Published: October 2021

Gaslighting is a modern term that describes a type of toxic relationship that psychologically abuses the victim. Gaslighting is understood as manipulating the victim into questioning his sanity and the gaslighter has a goal to create a ‘surreal’ environment that will cause the victim to feel like he is in the wrong and is crazy. Since gaslighting is all about manipulation, it can cause mental disorders. In the theoretical framework, we will apply the concept of gaslighting and self-actualization to show the effects of gaslighting and the ways to cope with it. In this work, we explore how gaslighting can cause anxiety, depression and low self-esteem in the victims. We show that the victims of gaslighting can deal with it by fulfilling physiological needs and building herself up again by the help of friends and families. Keywords: gaslighting, toxic relationship, poetry, lyrical poem
Golden: Reworking the Psychosocial Maldevelopment of the Obedient Kid
Authors: Noviani Angeline
Published: October 2021

Well-behaved children might seem well, but may actually harbor self-doubt, a strong sense of guilt, and a weak ego identity which will bring them problems emotionally and socially in their later life. This creative work, Golden, was created to raise a discussion on this issue by trying to answer how children may end up developing these traits, what the effects are, and how to recover. To answer this, Erik Erikson’s 8 stages of psychosocial development is used as the base for this coming-of-age drama musical screenplay. It follows the story of an obedient daughter, Annisa. Connected with the theory, Annisa ended with the dystonic “guilt” in the play age stage because of how her mother raised her. Thus, in adolescent stage she lacks emotional resilience in an initiative-based environment. However, since she is enduring the complications and growing a sense of trust, finally, she achieves balance and is healed. Keywords: good child, Erik Erikson, psychosocial maldevelopment, recovery, coming-of-age drama, musical film
SPLITSVILLE: A Play-with-Music Exploring Improper Divorce Disclosure’s Effects on Children
Authors: Abigail Emily
Published: October 2021

Going through a divorce is a difficult time for a family, including the children. In this COVID-19 pandemic era, when the divorce rate in Indonesia soars high, I conducted a research to find out how it affects children or how children respond to it, especially when the decision to divorce is taken without their knowledge. To analyze it, I used theories from communication science. From the result of that research, I made a musical script which portrays my findings, in the hopes that readers or audiences can understand children’s perspective of divorce. The findings are the fact that it makes children become aloof and lowers their self-esteem. Even though they have a lot of questions and uncertainties towards the future, they will choose to become distant to avoid the topic of divorce. The reasons being they are afraid that talking about it will bring more drastic change. Other than that, they do not trust their parents as much anymore, since they think that the parents have lied to them.Keywords: divorce, children, communication, aloof, play-with-music, comedy
Artificial flood reduces fine sediment clogging enhancing hyporheic zone physicochemistry and accessibility for macroinvertebrates
Authors: Mathers Kate L. , Robinson Christopher T. , Weber Christine
Published: October 2021

River regulation globally has reduced the riverine connectivity (longitudinal, lateral and vertically) with significant consequences for their abiotic and biotic components. To restore the ecological integrity of regulated rivers, artificial floods are increasingly being employed in large‐scale flow restoration efforts. Despite considerable recognition regarding the ecological and geomorphological effects of artificial floods on benthic habitats, understanding the implications for the hyporheic zone is essentially absent. This void in our management knowledge base is considerable given that one of the most widely associated consequences of flow regulation is excessive deposition of fine sediment (sedimentation; particles <2 mm) that often disconnects the hyporheic zone from surface waters.

In this study, we examined the effects of an artificial flood on the hyporheic zone of the River Spöl in Switzerland. Fine sediment content of shallow benthic substrates (ca. 10 cm) was significantly reduced following the flood. The flushing of fine sediment was also apparent in hyporheic substrates (depths of 0.25 and 0.50 m), resulting in a reconnection of previously clogged interstitial pathways. The opening of interstitial pore space enhanced physicochemical conditions in the hyporheic zone, such as improved dissolved oxygen concentrations, and supported greater taxa richness.

Alterations in the composition of shallower hyporheic assemblages (0.25 m) were evident following the flood. These results indicated that benthic pore space became more connected to surface waters following the flood, thereby enhancing accessibility for interstitial organisms.

Our results suggest that artificial floods can be an effective management tool to restore spatial heterogeneity in sediment composition and pore space and improve vertical connectivity for macroinvertebrates. We anticipate that artificial floods would be required on a regular basis given the re‐accumulation of fine sediment 10 months later in our study system. We encourage river managers and scientists to consider flow disturbance and restoration in a holistic manner that encompasses the multiple spatial dimensions of connectivity, including the hyporheic ecotone.
Virus Assembly
Authors: Rowlands David J , Stockley Peter G
Published: October 2021

Viral genomes are sequestered by capsid proteins to form nucleocapsids with icosahedral (pseudospherical) or helical symmetry. Mature virus particles (virions) may be naked (i.e. composed of nucleic acid and protein only) or enveloped within a lipid bilayer(s). There is great diversity in size and complexity across the virus spectrum; recently discovered giant viruses are larger than some bacteria. Virions assemble from relatively large numbers of a few identical subunits but may include additional proteins required for specialised functions. Various mechanisms ensure that only viral genomic nucleic acids are packaged. Virion components are transported by cellular processes to sites of assembly. Basic functions of virions are protection of the genome from environmental damage during extracellular existence and delivery to a susceptible cell to initiate a new infection. Proteolytic cleavage of specific proteins during virus maturation commonly induces a quasi‐stable ‘triggered’ state to allow conformational changes necessary for cell penetration and genome release.

Key Concepts

For genetic economy, virions are assembled from large numbers of a few components.

Nucleocapsids comprise the viral genomic nucleic acid sequestered within a protein coat.

The symmetry of nucleocapsids is usually icosahedral or helical.

Virions are either nonenveloped (i.e. a naked nucleocapsid) or enveloped by a lipid membrane.

Virus‐specific nucleic acids are selectively packaged within nucleocapsids.

Intracellular transport mechanisms are hijacked by viruses to ensure that components are delivered to sites of assembly.

Postassembly proteolytic cleavages are often used to induce a quasi‐stable state primed for cell entry.
MDMA, PTSD and the amygdala: Promising approach for treating SUDs
Authors: Knopf Alison
Published: October 2021

Most patients with substance use disorder (SUD) also have anxiety, and many have post‐traumatic stress disorder (PTSD), using drugs or alcohol to self‐medicate (although not effectively). What happens with PTSD occurs in the amygdala, explained George Koob, Ph.D., director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in an interview with ADAW last week. The emotional part of the brain, the amygdala gets out of control with PTSD, because it not only gives positive emotional feelings, but it also senses threat. It doesn't distinguish between a physical and an emotional threat, so feeling fearful, sad and unloved can all be felt as threats.
Continuous Energy Harvesting from Ubiquitous Humidity Gradients using Liquid‐Infused Nanofluidics
Authors: Zheng Shuang , Tang Jiayue , Lv Dong , Wang Mi , Yang Xuan , Hou Changshun , Yi Bo , Lu Gang , Hao Ruiran , Wang Mingzhan , Wang Yanlei , He Hongyan , Yao Xi
Published: October 2021

Humidity‐based power generation that converts internal energy of water molecules into electricity is an emerging approach for harvesting clean energy from nature. Here it is proposed that intrinsic gradient within a humidity field near sweating surfaces, such as rivers, soil, or animal skin, is a promising power resource when integrated with liquid‐infused nanofluidics. Specifically, capillary‐stabilized ionic liquid (IL, Omim+Cl‐) film is exposed to the above humidity field to create a sustained transmembrane water‐content difference, which enables asymmetric ion‐diffusion across the nanoconfined fluidics, facilitating long‐term electricity generation with the power density of ≈12.11 µW cm‐2. This high record is attributed to the nanoconfined IL that integrates van der Waals and electrostatic interactions to block movement of Omim+ clusters while allowing for directional diffusion of moisture‐liberated Cl+. This humidity gradient triggers large ion‐diffusion flux for power generation indicates great potential of sweating surfaces considering that most of the earth is covered by water or soil.
Synthesis of Functionalized 4,1‐Benzothiazepines via a [4+3] Annulation between Aza‐o‐Quinone Methides and Pyridinium 1,4‐Zwitterionic Thiolates
Authors: Wang Chuan‐Chuan , Liu Xue‐Hua , Wang Xin‐Lu , Cui Hua‐Peng , Ma Zhi‐Wei , Ding Degang , Liu Jun‐Tao , Meng Lei , Chen Ya‐Jing
Published: October 2021

The [4+3] annulation of aza‐o‐quinone methides and pyridinium 1,4‐zwitterionic thiolates has been developed for the one‐step synthesis of functionalized 2,3‐unsaturated 4,1‐benzothiazepines under mild and metal‐free conditions. The produced 4,1‐benzothiazepines can easily be converted into biologically interesting sulfoxides and sulfones via selective oxidization with m‐CPBA.

magnified image
Small Extracellular Vesicles Propagate the Inflammatory Response After Trauma
Authors: Seibold Tanja , Schönfelder Jonathan , Weeber Florian , Lechel André , Armacki Milena , Waldenmaier Mareike , Wille Christoph , Palmer Annette , Halbgebauer Rebecca , Karasu Ebru , Huber‐Lang Markus , Kalbitz Miriam , Radermacher Peter , Paschke Stephan , Seufferlein Thomas , Eiseler Tim
Published: October 2021

Trauma is the leading cause of death in individuals under 44 years of age. Thorax trauma (TxT) is strongly associated with trauma‐related death, an unbalanced innate immune response, sepsis, acute respiratory distress syndrome, and multiple organ dysfunction. It is shown that different in vivo traumata, such as TxT or an in vitro polytrauma cytokine cocktail trigger secretion of small extracellular nanovesicles (sEVs) from endothelial cells with pro‐inflammatory cargo. These sEVs transfer transcripts for ICAM‐1, VCAM‐1, E‐selectin, and cytokines to systemically activate the endothelium, facilitate neutrophil‐endothelium interactions, and destabilize barrier integrity. Inhibition of sEV‐release after TxT in mice ameliorates local as well as systemic inflammation, neutrophil infiltration, and distant organ damage in kidneys (acute kidney injury, AKI). Vice versa, injection of TxT‐plasma‐sEVs into healthy animals is sufficient to trigger pulmonary and systemic inflammation as well as AKI. Accordingly, increased sEV concentrations and transfer of similar cargos are observed in polytrauma patients, suggesting a fundamental pathophysiological mechanism.
Gate‐Tunable Magnetism via Resonant Se‐Vacancy Levels in WSe2
Authors: Nguyen Tuan Dung , Jiang Jinbao , Song Bumsub , Tran Minh Dao , Choi Wooseon , Kim Ji Hee , Kim Young‐Min , Duong Dinh Loc , Lee Young Hee
Published: October 2021

The confined defects in 2D van der Waals (vdW)‐layered semiconductors can be easily tailored using charge doping, strain, or an electric field. Nevertheless, gate‐tunable magnetic order via intrinsic defects has been rarely observed to date. Herein, a gate‐tunable magnetic order via resonant Se vacancies in WSe2 is demonstrated. The Se‐vacancy states are probed via photocurrent measurements with gating to convert unoccupied states to partially occupied states associated with photo‐excited carrier recombination. The magneto‐photoresistance hysteresis is modulated by gating, which is consistent with the density functional calculations. The two energy levels associated with Se vacancies split with increasing laser power, owing to the robust Coulomb interaction and strong spin–orbit coupling. The findings offer a new approach for controlling the magnetic properties of defects in optoelectronic and spintronic devices using vdW‐layered semiconductors.
Light‐Fueled Polymer Film Capable of Directional Crawling, Friction‐Controlled Climbing, and Self‐Sustained Motion on a Human Hair
Authors: Cheng Ming , Zeng Hao , Li Yifei , Liu Jianxun , Luo Dan , Priimagi Arri , Liu Yan Jun
Published: October 2021

Recent efforts in stimuli‐responsive soft materials have enabled wirelessly controlled actuation with increasing degrees of freedom, yielding miniature robots capable of various locomotion in open environments such as on a plane or inside fluids. However, grand challenges remain in harnessing photomechanical deformation to induce locomotion and control of friction during the movement, especially for robotic actuations within constrained spaces. Here, the authors report a centimeter‐long polymer strip made of a liquid crystal network that is capable of versatile light‐fueled motions along a human hair. The soft polymer robot can translocate directionally upon temporally modulated excitation and climb vertically through friction control with light. A self‐oscillating strip is demonstrated to continuously translocate along the hair upon a constant light stimulus, and its gaiting is associated to the smoothness of the hair surface. The results offer new insights to small‐scale photo‐actuator, mechanical control, and automation in soft micro robotics.
Response of organic grain and forage crops to struvite application in an alkaline soil
Authors: Thiessen Martens Joanne R. , Entz Martin H. , Schneider Kimberley D. , Zvomuya Francis , Wilson Henry F.
Published: October 2021

Struvite (NH4MgPO4·6H2O) may be an appropriate fertilizer to address phosphorus (P) deficiencies in organic cropping systems, but field studies assessing crop response to struvite are lacking. Field experiments were conducted over 3 yr on a low‐P, alkaline soil in Manitoba to assess the effect of struvite application rate on the yield and P accumulation of organically managed grain and forage crops. Struvite was applied to spring wheat (Triticum aestivum L.) and flax (Linum usitatissimum L.) at 0, 20, 30, and 40 kg P ha–1 in separate experiments each year and to alfalfa (Medicago sativa L.)–grass forage at 0, 30, 60, and 90 kg P ha–1 in a single application in a 3‐yr experiment. Wheat grain yield, P concentration, and P accumulation increased linearly with increasing struvite rate, whereas flax showed little to no response. Forage yield, P concentration, and P accumulation also increased with struvite rate. Benefits to forage yield and P accumulation were greatest in the second year, demonstrating important residual effects of struvite application. Struvite application shifted forage composition to become dominated by alfalfa whereas the unfertilized treatment was dominated by grasses. Annual P recovery efficiency was 4–7% for wheat, 1–2% for flax, and 7–12% for forage and did not vary significantly with struvite application rate. Our findings demonstrate that struvite applied at a relatively high rate is an effective P source for wheat and alfalfa‐based forage under organic management, but not for flax.
PUS3‐related disorder: Report of a novel patient and delineation of the phenotypic spectrum
Authors: Borghesi Alessandro , Plumari Massimo , Rossi Elena , Viganò Claudia , Cerbo Rosa Maria , Codazzi Alessia Claudia , Valente Enza Maria , Gana Simone
Published: October 2021

PUS3 encodes the pseudouridylate synthase 3, an enzyme catalyzing the formation of tRNA pseudouridine, which plays a critical role in tRNA structure, function, and stability. Biallelic pathogenic variants of PUS3 have been previously associated with severe intellectual disability, microcephaly, epilepsy, and short stature. We identified a novel homozygous PUS3 frameshift variant in a child with facial dysmorphisms, growth failure, microcephaly, retinal dystrophy, cerebellar hypoplasia, congenital heart defect, and right kidney hypoplasia. This patient further expands the phenotypic spectrum of PUS3‐related disorders to include a more severe syndromic presentation.
Additive manufacturing for adsorption‐related applications—A review
Authors: Pereira Ana , Ferreira Alexandre F. P. , Rodrigues Alírio E. , Ribeiro Ana Mafalda , Regufe Maria João
Published: October 2021

The effective shaping of adsorbents is essential to guarantee a high‐efficiency energetic process in what concerns adsorptive applications. In this way, additive manufacturing is gaining significance in developing structured materials in the field of gas adsorption processes. Additive manufacturing is a promising alternative to the traditional shaping techniques, which possess some drawbacks. This paper aims to review the state‐of‐art of additive manufacturing technologies in the manufacturing of adsorbent structures. To do so, an overview of the existent shaping techniques is done, followed by a summarized description of the leading existing additive manufacturing technologies. Then, the application of additive manufacturing technologies to the development of adsorbent materials and other materials for chemical engineering‐related applications is also reviewed.
Advances in Modeling Alzheimer's Disease In Vitro
Authors: Sharma Navatha Shree , Karan Anik , Lee Donghee , Yan Zheng , Xie Jingwei
Published: October 2021

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss and cognitive impairment, thereby disrupting the performance of daily activities. Numerous therapeutics have shown efficacy in animal AD models but failed in human patients. The key to understanding the etiology of AD lies in the development of effective disease models, which can ideally recapitulate all characteristics of the disease. Over the years, different approaches including in vitro, in vivo, and in silico models are able to resemble certain features of AD. In this review, the significance of different in vitro models including their merits and limitations in modeling AD is discussed, which will give a better perspective on the development of a comprehensive model that can mimic human AD. This starts with a brief introduction to AD and its pathology. Then it mainly focuses on the two‐dimensional, three‐dimensional and microfluidic in vitro models of AD that have made significant advancements in understanding AD pathology and aiding in screening effective therapeutics. Several 3D neural tissue engineering models developed in the last two decades along with a discussion on the future prospects in the development of efficient in vitro AD models are further highlighted.
CdSNPs@NPAN‐rGO‐PAN electrospinning film with enhanced photocatalytic activity via adjusting the fiber dimension
Authors: Ou Keru , Wang Ruiyu , Xiang Haifei , Liu Yongxin , Chen Xi , Zhang Richao , Zhang Jiali
Published: October 2021

In the paper, we report that CdSNPs@NPAN‐PAN and CdSNPs@NPAN‐rGO‐PAN composite photocatalysts were prepared by in situ growing CdS nanoparticles (CdSNPs) and N‐polyaniline (NPAN) on electrospinning films. The largest specific surface area of a fiber was made by adjusting the fiber diameter, and the photocurrent response and photodegradation of rhodamine B (RhB) experiments showed a more prominent current response and photocatalytic capacity for the CdSNPs@NPAN‐rGO‐PAN composite photocatalysts in contrast to the pure CdSNPs and CdSNPs@NPAN‐PAN photocatalysts. The nitrogen atoms on NPAN have hydrophilicity, and reduced graphene oxide (rGO) has large specific surface and high‐speed electron conductivity characteristics, which are the main factors for improving the catalytic performance. In addition, various other characterization methods had proven that CdSNPs@NPAN‐rGO‐PAN catalyst has better photocatalytic performance, and the feasible photocatalytic mechanism and cooperative effects were further analyzed in detail.
Bringing anatomy to life: Evaluating a novel ultrasound curriculum in the anatomy laboratory
Authors: Lufler Rebecca S. , Davis Margaret L. , Afifi Linda M. , Willson Robert F. , Croft Peter E.
Published: October 2021

As point‐of‐care ultrasound (POCUS) invades medical specialties, more students covet earlier ultrasound (US) training programs in medical school. Determining the optimal placement and format in the curriculum remains a challenge. This study uses student perceptions and confidence in interpreting and acquiring images to evaluate the effectiveness of an US curriculum and assesses their performance on US content. A unique US curriculum was incorporated into first‐year clinical anatomy at Tufts University School of Medicine (TUSM). Students completed surveys evaluating changes in US confidence and perceptions. Mean ratings on pre‐ and post‐surveys were compared using Mann–Whitney U tests. Performance on US examination questions was evaluated. Two independent evaluators coded narrative responses and NVivo software was used to identify common themes. Two hundred eleven students completed the US curriculum. Students reported higher post‐curriculum mean confidence ratings on US comprehension, operation, image acquisition, artifact recognition, and normal image interpretation (P < 0.0001). US reinforced anatomy concepts and clinical correlates (9.56, ±0.97 SD; 9.60, ±1.05). Students disagreed with items stating learning US is too difficult (1.2, ±2.2) and that it interferes with learning anatomy (0.68, ±1.7). Students scored above passing on practical US knowledge questions, supporting survey data, and the relation to learning spatial relationships. Qualitative analysis identified seven major themes and additional subthemes. Limited integration of US breaks barriers in students' perceptions and confidence in performing POCUS. The TUSM US curriculum is a natural marriage of anatomy and POCUS applications, serving as a template for medical schools.
Aquablation therapy in large prostates (80–150 cc) for lower urinary tract symptoms due to benign prostatic hyperplasia: WATER II 3‐year trial results
Authors: Zorn Kevin C. , Bidair Mohamed , Trainer Andrew , Arther Andrew , Kramolowsky Eugene , Desai Mihir , Doumanian Leo , Elterman Dean , Kaufman Ronald P. , Lingeman James , Krambeck Amy , Eure Gregg , Badlani Gopal , Plante Mark , Uchio Edward , Gin Greg , Goldenberg S. Larry , Paterson Ryan , So Alan , Humphreys Mitchell , Roehrborn Claus , Kaplan Steven , Motola Jay , Bhojani Naeem
Published: October 2021

Objective

The objective of this study is to determine if Aquablation therapy can maintain its effectiveness in treating men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with large‐volume (80–150 cc) prostates at 3 years.

Subjects and Methods

One hundred one men with moderate‐to‐severe BPH symptoms and prostate volumes between 80 and 150 cc were enrolled in a prospective, nonrandomized, multicenter, international clinical trial in late 2017. Baseline, procedural, and follow‐up parameters were recorded at baseline and scheduled postoperative visits. IPSS, Qmax, and treatment failure are reported at 3 years.

Results

The mean prostate volume was 107 cc (range 80–150). Mean IPSS improved from 23.2 at baseline to 6.5 at 3 years (16.3‐point improvement, p < 0.0001). Mean IPSS quality of life improved from 4.6 at baseline to 1.1 at 3 years (improvement of 3.4 points, p < 0.0001). Maximum urinary flow increased from 8.7 to 18.5 cc/s. At 3 year follow‐up, 6% of treated patients needed BPH medication and an additional 3% required surgical retreatment for LUTS.

Conclusions

Three‐year follow‐up demonstrates a sustained symptom reduction response along with low irreversible complications to Aquablation in men with LUTS due to BPH and prostates of 80–150 cc. Current treatment options available for men with prostates of this size have similar efficacy outcomes but are burdened with high rates of irreversible complications. There are now numerous clinical studies with Aquablation used in various prostates sizes, and it should be offered as an option to men with LUTS due to BPH.
A framework for calculating orthogonal selectivities in multimodal systems directly from cell culture fluid
Authors: Vecchiarello Nicholas , Timmick Steven M. , Cramer Steven
Published: October 2021

This paper presents a straightforward approach for measuring and quantifying orthogonality directly in complex cell culture fluids (CCFs) without the requirement for tracking the retention behaviors of large sets of proteins. Null‐producing CCFs were fractionated using linear salt gradients at constant pH on a set of multimodal resins. Fractions were then analyzed by ultraperformance‐reversed phase liquid chromatography and the resulting chromatograms provided host cell protein (HCP) “fingerprints.” Using these fingerprints, an inner product vector‐based approach was employed to quantify the degree of orthogonality between pairs of resins and operating conditions for these large HCP protein sets. To compare resin orthogonality behavior in different expression systems, the Chinese hamster ovary and Pichia pastoris null‐producing CCFs were examined. Orthogonality in multimodal systems was found to strongly depend on the expression system and the HCPs being screened. We also identified several unexpected pairs of multimodal resins within the same family that exhibited significant orthogonality. Furthermore, “self‐orthogonality” was evaluated between resins operated at different pHs, and important operating regimes were identified for maximizing orthogonal selectivities. The framework developed in this paper for calculating orthogonality without the need for labor‐intensive HCP tracking has important implications for efficient process development and resin/operating condition selection for both monoclonal antibody (mAb) polishing steps and non‐mAb processes. In addition, this study provides a tool to unlock the untapped potential of multimodal resins by aiding in their rational selection and incorporation. Finally, the orthogonality framework here can facilitate the development of sets of next‐generation multimodal resins specifically designed to provide highly orthogonal and efficient separations tailored for different expression systems.
Group radical openness: A feasibility study
Authors: Egan Rachel , Long Emer , McElvaney James , Booth Richard
Published: October 2021

Background

Recent research has suggested that too much self‐control (overcontrol) underpins a range of mental health disorders including certain Axis I mood and eating disorders, and Axis II presentations such as obsessive compulsive personality disorder and avoidant personality disorder. A novel group therapy intervention, Group Radical Openness (GRO), is proposed as a suitable treatment for overcontrol.

Aims

To explore whether appropriate participants for the intervention can be recruited; to investigate whether outcome measures are fit for purpose; to determine whether the intervention is suitable and acceptable to participants; and to determine whether GRO shows promise with the intended population.

Method

A mixed‐methods design was chosen, using statistical analysis on two primary measures and three secondary measures to assess pre–post outcomes and 6‐month follow‐up. This was combined with descriptive interpretive analysis of client interviews post‐intervention. Research participants were outpatients who attended GRO. The sample (N = 14; 6 females and 8 males; mean age 44.4 years; age range 18–58) attended 26, three‐hour group sessions.

Results

Quantitative data were analysed using repeated‐measures ANOVA. Participant scores on the two primary measures, The Five‐Factor Obsessive–Compulsive Inventory—Short Form (FFOCI‐SF) and the Brief Symptom Inventory (BSI), yielded significant results that were maintained at 6‐month follow‐up. Qualitative data found that participants reported changes across the three themes that are addressed in the GRO programme.

Discussion

This feasibility study found that GRO showed promise as a suitable intervention for individuals who are overcontrolled. Further intervention effectiveness research is warranted.