bluuebunny/crossref_metadata_2025 huggingface dataset:
Need to adopt scaled decentralized systems in the water infrastructure to achieve sustainability and build resilience
Authors: Kalbar Pradip P. , Lokhande Shweta
Published: March 2023

Urban water infrastructure (UWI) in cities faces enormous pressure to cope with increased water demands, handle extreme events and improve the service with minimum resource consumption and environmental impacts. The current study presents an approach for addressing the challenges in UWI, specifically in water supply and sewerage. The article argues a need for a paradigm shift that simultaneously includes the sustainability and resilience aspects throughout the life cycle of UWI. The article further highlights the issues in the prevailing approach of centralized infrastructure and demonstrates the necessity of moving away from such an approach and shifting towards decentralized infrastructure. Understanding the factors accelerating decentralization to attain a paradigm shift to decentralization is necessary. Hence, the study first identifies the drivers of decentralization. Secondly, the need for an appropriate scale to be considered while implementing decentralized UWI is highlighted in this study. Furthermore, the effect of the scale of infrastructure is discussed through the trade-offs between life-cycle costs, ease of governance, resilience and recycling benefits. The approach of scaled decentralization outlined in the study will be useful for developing countries to plan new infrastructure and also for developed countries to replace the ageing UWI to create future sustainable and resilient urban systems
Decreasing dietary nitrogen consumption improves wastewater treatment efficiency and carbon footprint
Authors: Rautiainen Nea , Rantanen Pirjo-Liisa , Jalava Mika , Mikola Anna
Published: March 2023

This article aimed to connect protein consumption with the nitrogen load to wastewater treatment plants (WWTPs) in Finland. The influence of the changes in nitrogen consumption on the WWTP environmental footprint was estimated using process simulation. As the main result, a connection was found between nitrogen loads from food consumption and the incoming load to a WWTP. This was done by analysing protein consumption data from the Food and Agriculture Organization of the United Nations (FAO) and incoming nitrogen load data from the Finnish environmental institute, SYKE. The impact of nitrogen consumption was estimated using different diet scenarios. Decreasing dietary nitrogen consumption by 16–24% could decrease nitrous oxide emissions by 16–24% and aeration energy (AE) consumption by 6–11%. An increase in dietary nitrogen consumption of 6–42% could increase AE consumption by 2–14% when effluent requirements were met. When considering the environmental impact of this increased aeration, it corresponds to an increase of 2–16%. Furthermore, nitrous oxide emissions could rise by 6–42% This information can be valuable to WWTPs and even consumers for influencing incoming nitrogen loads.
Enhancing stormwater management with low impact development (LID): a review of the rain barrel, bioretention, and permeable pavement applicability in Indonesia
Authors: Putri Fidyasari Kusuma , Hidayah Entin , Ma'ruf Mokhammad Farid
Published: March 2023

Low impact development (LID) is a sustainable land use and planning strategy that aims to minimize the environmental impacts of development. A community can enhance their water resources and create sustainable and resilient neighbourhoods. This approach has demonstrated success in managing stormwater and promoting water reuse globally, however, its suitability in developing countries like Indonesia remains uncertain and requires further investigation. The implementation of LID in developing countries may face several challenges including high density and complex drainage networks, combined sewer usage, clay soil type, irregular housing layouts, community socio-economic characteristics, affordability, cost, and the availability of regulations and policies. With proper planning and site-specific strategies, LID can be implemented effectively in Indonesia. Clear regulations, secured funding source and community-based LID are all essential for successful LID deployment. This paper can be used as a starting point for considering LID implementation in Indonesia and other countries with similar characteristics.
DIREITOS DE PROPRIEDADE INTELECTUAL E MODELOS DE INOVAÇÃO ABERTA (OPEN INNOVATION)
Authors: Magalhães Júnior Danilo Brum de
Published: March 2023

Trata-se de um ensaio teórico, de natureza exploratória, baseado num levantamento bibliográfico, mediante o diálogo com diversas correntes da literatura de gestão e do Direito de Propriedade Intelectual, que tem por objetivo geral compreender as implicações na gestão da propriedade intelectual nas organizações que utilizam o sistema de inovação aberta (open innovation). Não houve, neste trabalho, a pretensão de se confirmar a empiricamente a efetividade da norma. A proposta ocupou-se de relacionar os conceitos teóricos e promover uma reflexão sobre a temática visando uma discussão dos conceitos de inovação aberta e sua relação com o Direito de Propriedade Intelectual. O argumento deste trabalho é que que pesquisas iniciais sobre inovação aberta conduzidas por Henry Chesbrough já indicavam que os Direitos de Propriedade Intelectual teriam um papel importante neste contexto de inovação aberta. Atualmente, apesar de algumas críticas na literatura acerca da possibilidade da Propriedade Intelectual limitarem os avanços da inovação aberta, estudos demonstram que as empresas enxergam os Direitos de Propriedade Intelectual como importantes para o desenvolvimento de modelos de inovação aberta, na medida que servem para: (i) aumentar a cooperação entre as partes de um sistema de inovação aberta, na medida que traz mais segurança ao intercâmbio de conhecimento entre as empresas; e (ii) tornar possível a à exploração comercial dos resultados de atividades inventivas das empresas que não estão nos planos de desenvolvimento pela própria empresa.
INOVAÇÃO NO USO E ACEITAÇÃO DE NOVA TECNOLOGIA EM CARTÓRIOS
Authors: Linhares Thales Cavalcante , Eckert Alex
Published: March 2023

A evolução tecnológica tem ganhado espaço cada vez mais nítido na atuação dos vários profissionais do setor público e privado, chegando também aos tabelionatos de notas de todo Brasil, com mecanismos e plataformas on-line que facilitam a realização dos serviços cartorários. Assim, o objetivo desta pesquisa é analisar a percepção sobre os construtos percepção de expectativa de desempenho, expectativa de esforço, influência social e condições facilitadoras como elementos intervenientes na intenção de uso da tecnologia, especialmente da plataforma e-notariado, sob o ponto de vista registradores, tabeliões e funcionários dos cartórios no âmbito da Região Norte do Estado do Ceará. Classificada como exploratória e descritiva, a pesquisa adotou a técnica de investigação com método survey, via coleta de questionários. Os resultados encontrados indicaram que existem repercussões positivas entre a intenção de uso da tecnologia e as variáveis expectativa de desempenho, expectativa de esforço, influência social e condições facilitadoras. Além disso, os resultados mostraram diferenças estatísticas ao comparar os níveis de escolaridade com as condições facilitadoras, demonstrando que pessoas com nível superior apresentam maior índice de condições facilitadoras.
Features of a Balanced Healthy Diet with Cardiovascular and Other
Benefits
Authors: Manolis Antonis A. , Manolis Theodora A. , Melita Helen , Manolis Antonis S.
Published: March 2023

Background:

Cardiovascular (CV) disease (CVD) remains the leading cause of death globally.
Besides lack of exercise, obesity, smoking, and other risk factors, poor nutrition and unhealthy/
unbalanced diets play an important role in CVD.

Objective:

This review examined data on all issues of the CV-health benefits of a balanced diet, with
tabulation of nutritional data and health-authority recommendations and pictorial illustration of the main
features of a CV-healthy diet.

Methods:

PubMed and Google Scholar were searched for relevant studies and reviews on diet and CV
health.

Results:

For a long time, there has been evidence, corroborated by recent findings, that pro-vegetarian
diets have a beneficial influence on serum lipid levels, markers of inflammation and endothelial function,
prooxidant-antioxidant balance, and gut microbiome, all probably contributing to reduced CV risk.
Worries about the nutritional adequacy of vegetarian diets are circumvented by obtaining certain nutrients
lacking or found in lower amounts in plants than in animal foods, by consuming a wide variety of
healthy plant foods and through intake of oral supplements or fortified foods. Well-balanced diets, such
as the Mediterranean or the Dietary-Approaches-to-Stop-Hypertension diets, provide CV-health benefits.
Nevertheless, a broad variety of plant-based diets with low/minimal animal food intake may allow
for a personalized and culturally adjusted application of dietary recommendations contributing to the
maintenance of CV health.

Conclusion:

Universal adoption of a balanced CV-healthy diet can reduce global, CV and other mortality
by ~20%. This requires world-wide programs of information for and education of the public, starting
with school children and expanding to all groups, sectors, and levels.
Synthesis and Biological Evaluation of Paclitaxel-aminoguanidine
Conjugates for Suppressing Breast Cancer
Authors: Dai Yi , Zhang Yang , Zhang Lvfeng , Song Zurong
Published: March 2023

Background:

A combination of paclitaxel with antineoplastic agents or paclitaxel
alone was used clinically for the treatment of metastatic breast cancer. However, paclitaxel has
poor water solubility and limited effect on some metastatic breast cancers. Hence, novel
paclitaxel derivatives are in demand. In addition, the inducible nitric oxide synthase inhibitor,
and aminoguanidine has a synergistic antitumor effect with chemotherapeutics.

Objective:

This study aims to design and synthesize the paclitaxel-aminoguanidine conjugates.
Upon cellular internalization, the novel paclitaxel-aminoguanidine conjugates could release
paclitaxel and aminoguanidine with the aid of esterase and weak acids in cancer cells.

Methods:

Paclitaxel-aminoguanidine conjugates were synthesized using click chemistry. The
biological activity of paclitaxel-aminoguanidine conjugates was evaluated by MTT assay,
determination of nitric oxide, analysis of apoptosis and cell cycle, and wound healing assay.

Results:

Here, a novel paclitaxel-aminoguanidine conjugate was synthesized using click chemis-try. Compared with paclitaxel, the water solubility of paclitaxel-aminoguanidine conjugates increased obviously. Upon cellular internalization, the novel paclitaxel-aminoguanidine conjugates released paclitaxel and aminoguanidine to synergistically inhibit the proliferation and metastasis of breast cancer cells with the aid of esterase and weak acids in cancer cells. The results of the MTT assay showed that compared with paclitaxel or the mixture of paclitaxel and aminoguanidine, the cytotoxicity of compound 4 against 4T1 cells was enhanced. As for apoptosis induced by these compounds, the paclitaxel-aminoguanidine conjugates also had a stronger ability to induce apoptosis than paclitaxel or the mixture of paclitaxel and aminoguanidine. The results of the scratch test showed that the anti-metastatic effect of the con-jugate was the strongest among these tested compounds.

Conclusion:

These findings indicate that paclitaxel-aminoguanidine conjugate is a promising
anticancer agent worthy of further study.
Chlorogenic Acid Inhibits Proliferation, Migration and Invasion of
Pancreatic Cancer Cells via AKT/GSK-3β/β-catenin Signaling Pathway
Authors: Chen Xiaoliang , Liu Binyu , Tong Jiale , Bo Jianing , Feng Miao , Yin Lili , Lin Xiukun
Published: March 2023

Background:

Chlorogenic acid (CA, United States Patent No. 10772340), a natural
biologically active food ingredient, displays potent antitumor activity against a variety of cancer
cells. However, the mechanism underlying its anticancer effect is not well elucidated.

Objective:

In the present study, we hope to dissect the mechanism underlying the anticancer effects
of CA in pancreatic cancer cells.

Methods:

The cytotoxicity of CA in pancreatic cancer cells was determined by MTT assay. Flow
cytometry was performed to evaluate the cells apoptosis, while a clonogenic assay was carried out
to check the colony formation of cancer cells. Transwell assay was performed to assess the cells
migration and invasion. The protein expression of AKT/GSK-3β/β-catenin signaling pathway was
detected by Western Blot.

Results:

Our data indicated that CA inhibited the proliferation of PANC-28 and PANC-1 cells in a
dose and time-dependent manner. CA was able to inhibit colony formation, migration, and invasion
ability and trigger apoptosis in PANC-28 and PANC-1 cells. Further study showed that CA
down-regulated the expression of AKT, p-AKT(Thr308), p-GSK-3β(Ser9), β-catenin, N-cadherin,
and vimentin while enhancing the expression of cleaved-caspase 3 and cleaved-caspase 7 in
PANC-28 and PANC-1 cells.

Conclusion:

Our study provides significant evidence that CA is able to inhibit the growth of pancreatic
cancer via the AKT/GSK-3β/β-catenin signaling pathway.
Design and Development of Aluminum Frame Unmanned Aerial Vehicle Hexacopter Configuration to Support Heavy Payload
Authors: Arief Ulfah Mediaty , Wicaksono Pramudyo , Yarman Indah Novi
Published: March 2023

Previous research has proven that the use of Unmanned Aerial Vehicles (UAVs) can increase the efficiency of human work. However, the design of the usefulness of UAV is considered to be limited. This limitation, for example, is that the UAV's lifting capacity is only capable of lifting 3-5 kilograms of load on average. In addition, the main material of the UAV frame also uses carbon fiber produced by build-up factories abroad, this makes the UAV design less economical. Furthermore, this study discusses the development of the UAV's lifting capacity of 25 kilograms to be able to lift the pesticide liquid load and considers the economic value. The hexacopter type multicopter UAV design was chosen in this study, equipped with 6 main propulsion rotors capable of carrying out its main task of lifting heavy loads, compared to the multicopter type of fewer than 6 rotors. The design is carried out by calculating the lifting force and analyzing the strength structure of the frame material with the help of AutoDesk Inventor software. The final result of the study was that the aluminum-based heavy-lift hexacopter drone was able to support heavy loads, as evidenced by structural analysis simulations resulting in a safety factor value of 1.67 ul, equipped with a 120KV rotor, 23x88 inch propeller, and 6S lipo battery 16,000 mAh, with a total weight of the frame 15kg drone flying for 19 minutes, with an additional 10kg of load the drone can fly for 6 minutes. This research can be developed by adding a nozzle or griper so that it can lift the pesticide spraying tank on a large enough agricultural land.
Human Blood Grup and Rhesus Detection Tool Prototype Design Based On IoT
Authors: Hendrawati Trisiani Dewi , Hasanudin Inzaghi
Published: March 2023

Currently, medical practitioners carry out blood type and rhesus examinations by directly observing the agglutination reaction and depending on the examiner's eye. Meanwhile, the effects of eye fatigue and saturation will cause inaccurate data. Therefore, a detection device was made which aims to display information about reading human blood type and rhesus on a digital display which can also store the data into a database. The ABO and rhesus systems were used in this study. This research was made using a real-time method based on the internet of things (IoT). sending data in real-time using WiFi Module ESP-01 and other components such as LCD microcontroller, LDR, LED, battery, and Arduino Uno. based on the results of tool testing, the percentage of success values is  91.67%.
Development of Web-Based Project Tender Documents Application Using Extreme Programming Methods
Authors: Lamada Mustari , Bakry Aminuddin , Ifani Aulyah Zakilah , Khaerunnisa Khaerunnisa
Published: March 2023

The application of technology is a need that is in demand in the industrial world today, especially in the field of contractors of goods and services that have implemented the use of applications to help the process of managing data and project documents in their companies. This study aims to optimize the web-based project tender document system using the extreme programming method. The extreme programming method consists of planning, design, coding, testing, and software increment. Research methods using extreme programming methods consisting of planning, design, coding, testing, and software increment. The planning stages obtain results in the form of functional and non-functional application needs. The design stage results in the design of applications using activity diagrams, diagram classes, use case diagrams, and flowcharts. The coding stages obtain results in the form of applications that can be built using web programming languages. The testing stage uses the ISO 9126 standard. Suitability test results are worth 1 (very good), security is not found to have viruses or malicious malware in applications (grade B), reliability is worth 0.99 (good), usability is worth 90.9% (very feasible), efficiency is worth 98% (grade A), maintainability meets the three standard aspects of assessment (good), and portability is worth 1 (very good). The software increment stage obtained results in the form of implementation and application trials on users who have functioned properly. Based on the results, it can be concluded that the development of web-based project tender document applications using extreme programming methods can function properly and be feasible to use.
The Role of Teachers in Fostering the Entrepreneurial Attitude of Elementary School Students through Scouting
Authors: Baturetno Wahyuni , Fathoni Ahmad , Zifa Minsih , Prastiwi Yenny
Published: March 2023

Entrepreneurial education needs to be instilled in children from an early age so that they are ready to face the challenges of the times. This research aims to describe: 1) the role of teachers in fostering entrepreneurial attitudes through scouting. 2) obstacles and solutions in fostering entrepreneurial attitudes through scouting This research uses qualitative methods with a phenomenological approach. This research was conducted at one of the State Elementary Schools in Baturetno Wonogiri Regency, Central Java. The data collected is qualitative data in the form of narratives about the role of teachers in fostering entrepreneurial attitudes through scouting. The data source used is the primary data source and the secondary data source. Data collection techniques in this study include observation techniques, interviews and documentation. Data analysis techniques in this study use interactive techniques. The results of research 1) In carrying out scouting activities or scout excursions are carried out on Fridays when at the time of lessons, because learning is still face-to-face limited.2) The role of teachers in fostering student entrepreneurship attitudes by building entrepreneurship attitudes, so that learners like challenges, creative and innovative, and more courageous in making decisions. 3) In cultivating an entrepreneurial attitude there are several obstacles that must be faced by scouting teachers. There are obstacles that come from teachers and students The existing constraints must be overcome so that the desired goal can be achieved
Digital Readiness in Physical Education and Sports Health Learning: Study at Elementary School, Yogyakarta
Authors: Kriswanto Erwin Setyo , Firmansyah Firmansyah , Meikahani Ranintya , Kurniawan Dennis Dwi , Mulyawan Rizki
Published: March 2023

Existing technological developments require all fields to be able to adjust to conditions in terms of technology. Several studies related to the use of technology during the COVID-19 pandemic in Indonesia show the unpreparedness of educators to adapt to emergency conditions that demand the use of online and hybrid learning, especially in PJOK subjects. Based on this, the researcher aims to determine the pattern of distance learning carried out by Physical Health and Sports Education teachers in elementary schools in Yogyakarta. Sequential explanatory design is used with quantitative and qualitative research approaches that are carried out sequentially. This research aims to analyze the need to develop learning media that can be used online, offline and in blended learning. The analysis of existing learning patterns shows that most teachers have met the standards of distance learning implementation. However, learning media development on certain materials still needs to be done to support each material delivery activity carried out by the teacher. The survey results show that most teachers still use teaching materials in print or electronic form and existing learning videos. The results of in-depth interviews indicate that there is still a need to develop learning media on athletic activities, self-defense, physical fitness development activities, gymnastics, rhythmic motion, water activities, personal safety, and a healthy lifestyle. With the results of this analysis, it is hoped that it can provide ideas and inspiration for further research in developing learning media, especially Physical Health and Sports Education in elementary schools so that educational goals towards the era of society 5.0 involve various technological developments can be achieved optimally both in emergency and normal conditions.
Boletín Agroclimático Regional: mesa técnica agroclimática de Magdalena, Cesar, La Guajira y Atlántico abril 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Magdalena, Cesar, La Guajira y Atlántico, es un espacio de diálogo y análisis entre actores locales, regionales y nacionales, que busca comprender el posible comportamiento del clima. Se realizó reunión presencial con transmisión remota (virtual) donde se presenta la perspectiva climática para el trimestre abr – jun 2022 para los departamentos de Magdalena, Cesar, La Guajira y Atlántico. Con base en esta información, se debatieron los posibles impactos y recomendaciones para el sector agropecuario de la región. La información generada se ha recopilado en el presente Boletín Agroclimático para la edición correspondiente del mes de abril de 2022, edición a cargo de AGROSAVIA Centro de Investigación Caribia y se presenta por cultivo o sector productivo.
Boletín Agroclimático Regional: mesa técnica agroclimática de Caldas agosto 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

Este Boletín fue el resultado de la Mesa Técnica Agroclimática (MTA) realizada el 05 de agosto 2022 , donde participaron diferentes expertos, técnicos y asociaciones de productores, con el apoyo del MADR, FAO, Sec . Agricultura y desarrollo Rural de Caldas e IDEAM . El Boletín Agroclimático es producto de una iniciativa nacional, propuesta por el Ministerio de Agricultura y Desarrollo Rural (MADR), que dirige a Colombia hacia una agricultura sostenible y adaptada al clima. El documento contiene el análisis climático mensual y las recomendaciones para que los sectores agropecuarios las incorporen en la toma de decisiones.
Boletín Agroclimático Regional: mesa técnica agroclimática de Tolima mayo 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Tolima, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Boletín Agroclimático Regional: mesa técnica agroclimática de la Isla de San Andrés abril 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de San Andrés, Providencia y Santa Catalina, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Boletín Agroclimático Regional: mesa técnica agroclimática de Magdalena, Cesar, La Guajira y Atlántico marzo 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Magdalena, Cesar, La Guajira y Atlántico (MCGA), es un espacio de diálogo y análisis entre actores locales, regionales y nacionales, que busca comprender el posible comportamiento del clima. En esta oportunidad, durante la reunión en modalidad virtual se presenta la perspectiva climática para el trimestre mar – mayo 2022 para los departamentos de Magdalena, Cesar, La Guajira y Atlántico. Con base en esta información, se debatieron los posibles impactos y recomendaciones para el sector agropecuario de la región. La información generada se ha recopilado en el presente Boletín Agroclimático para la edición correspondiente del mes de marzo de 2022 a cargo de CENIPALMA y se presenta para cada cultivo o sector productivo.
Boletín Agroclimático Regional: mesa técnica agroclimática de Putumayo julio 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Putumayo, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Effectiveness of the Lilly Connected Care Program in Improving Glycemic Management Among Patients With Type 2 Diabetes in China: Retrospective Real-world Study
Authors: Su Benli , Chen Yu , Shen Xingping , Guo Jianchao , Ding Yuchen , Ma Xiao , Yang Yuxin , Liu Dongfang
Published: March 2023

Background

Type 2 diabetes mellitus (T2DM) is a worldwide public health concern. Mobile health management platforms could be a potential way to achieve effective glycemic control.

Objective

This study aimed to evaluate the real-world effectiveness of the Lilly Connected Care Program (LCCP) platform in glycemic control among patients with T2DM in China.

Methods

This retrospective study included Chinese patients with T2DM (aged ≥18 years) from April 1, 2017, to January 31, 2020, for the LCCP group and from January 1, 2015, to January 31, 2020, for the non-LCCP group. Propensity score matching was used to match the LCCP and non-LCCP groups to reduce confounding, with covariates including age, sex, the duration of diabetes, baseline hemoglobin A1c (HbA1c), and the number of oral antidiabetic medication classes. HbA1c reduction over 4 months, the proportions of patients achieving an HbA1c reduction of ≥0.5% or ≥1%, and the proportions of patients reaching to target HbA1c level of ≤6.5% or <7% were compared between the LCCP and non-LCCP groups. Multivariate linear regression was used to assess factors associated with HbA1c reduction.

Results

A total of 923 patients were included, among whom 303 pairs of patients were well matched after propensity score matching. HbA1c reduction during the 4-month follow-up was significantly larger in the LCCP group than the non-LCCP group (mean 2.21%, SD 2.37% vs mean 1.65%, SD 2.29%; P=.003). The LCCP group had a higher proportion of patients with an HbA1c reduction of ≥1% (209/303, 69% vs 174/303, 57.4%; P=.003) and ≥0.5% (229/303, 75.6% vs 206/303, 68%; P=.04). The proportions of patients reaching the target HbA1c level of ≤6.5% were significantly different between the LCCP and non-LCCP groups (88/303, 29% vs 61/303, 20.1%; P=.01), whereas the difference in the proportions of patients reaching the target HbA1c level of <7% was not statistically significant (LCCP vs non-LCCP: 128/303, 42.2% vs 109/303, 36%; P=.11). LCCP participation and higher baseline HbA1c were associated with a larger HbA1c reduction, whereas older age, longer diabetes duration, and higher baseline dose of premixed insulin analogue were associated with a smaller HbA1c reduction.

Conclusions

The LCCP mobile platform was effective in glycemic control among patients with T2DM in China in the real world.
Machine Learning Approaches for Predicting Psoriatic Arthritis Risk Using Electronic Medical Records: Population-Based Study
Authors: Lee Leon Tsung-Ju , Yang Hsuan-Chia , Nguyen Phung Anh , Muhtar Muhammad Solihuddin , Li Yu-Chuan Jack
Published: March 2023

Background

Psoriasis (PsO) is a chronic, systemic, immune-mediated disease with multiorgan involvement. Psoriatic arthritis (PsA) is an inflammatory arthritis that is present in 6%-42% of patients with PsO. Approximately 15% of patients with PsO have undiagnosed PsA. Predicting patients with a risk of PsA is crucial for providing them with early examination and treatment that can prevent irreversible disease progression and function loss.

Objective

The aim of this study was to develop and validate a prediction model for PsA based on chronological large-scale and multidimensional electronic medical records using a machine learning algorithm.

Methods

This case-control study used Taiwan’s National Health Insurance Research Database from January 1, 1999, to December 31, 2013. The original data set was split into training and holdout data sets in an 80:20 ratio. A convolutional neural network was used to develop a prediction model. This model used 2.5-year diagnostic and medical records (inpatient and outpatient) with temporal-sequential information to predict the risk of PsA for a given patient within the next 6 months. The model was developed and cross-validated using the training data and was tested using the holdout data. An occlusion sensitivity analysis was performed to identify the important features of the model.

Results

The prediction model included a total of 443 patients with PsA with earlier diagnosis of PsO and 1772 patients with PsO without PsA for the control group. The 6-month PsA risk prediction model that uses sequential diagnostic and drug prescription information as a temporal phenomic map yielded an area under the receiver operating characteristic curve of 0.70 (95% CI 0.559-0.833), a mean sensitivity of 0.80 (SD 0.11), a mean specificity of 0.60 (SD 0.04), and a mean negative predictive value of 0.93 (SD 0.04).

Conclusions

The findings of this study suggest that the risk prediction model can identify patients with PsO at a high risk of PsA. This model may help health care professionals to prioritize treatment for target high-risk populations and prevent irreversible disease progression and functional loss.
Virtual First Emergency Medicine Visits: The Future of Convenient and Efficient Emergency Care
Authors: Sakumoto Matthew
Published: March 2023

The COVID-19 pandemic has led to increased patient volumes, staff shortages, and limited resources in emergency departments, resulting in the rapid acceleration of telemedicine in emergency medicine. The virtual first (VF) program connects patients with emergency medicine clinicians via synchronous virtual video visits, reducing unnecessary emergency department visits and diverting patients to appropriate care settings. VF video visits can improve patient outcomes by providing early intervention for acute care needs and can enhance patient satisfaction by providing convenient, accessible, and personalized care. However, challenges include the lack of physical examination, clinician telehealth training and competencies, and the requirement for a robust telemedicine infrastructure. Additionally, digital health equity is important to ensure equitable access to care. Despite these challenges, the potential benefits of VF video visits in emergency medicine are substantial, and this study is a strong step in building the evidence base for these advancements.
Austrian future cubicle: commuting, e-commuting or both?
Authors: Beno Michal , Caganova Dagmar
Published: March 2023

Austria tries to reach its decarbonisation targets by 2050. The significant attention lies in the carbon intensity of transport, with commuting of particular interest. The paper presents E-Commuting practices that are suitable tools to intervene in these journeys; however, it seems to be difficult. Exploring and understanding the commuting system of everyday lives is crucial. It is through this understanding that alternative avenues for intervention arise, for example into the practice of flexible working models. To understand the influence of e-commuting, the questionnaire via WhatsApp of 685 respondents was conducted, which considered an understanding of work and the commute necessary. The aim of the paper was to explore the workers' routines for in-office days and work-from-home days. The results show that the employees want to work remotely full or in hybrid mode and this trend is going forward. The employees are more productive with flexibility mode – 73.08%; they wish more flexibility in terms of returning to the cubicle – 71.79%; they desire the same amount of time of flexibility and going into the cubicle – 70.51%. Finally, in the case of any flexibility in their current organization, they would consider looking for another job that did not require return to the cubicle with the same salary – 53.85%.
Recent Advancements in Transdermal Drug Delivery System: A Review
Authors: Jain Rajesh , Goswami Dr.Manish , Mittal Dr.Sanjeev Kumar , Simran
Published: March 2023

Other non-invasive administration methods have recently become an alternative to the more conventional method of ingesting medications, which involves using a needle. The Transdermal Drug Delivery System (TDDS) is the most attractive method among them because of its low rejection rate, appreciable simplicity of administration, and superior convenience for patients. TDDS may find applications not only in the pharmaceutical industry but also in the sectors of skincare and cosmetics. This technique focuses mainly on delivering the medication in a particular area. As a result, it could reduce the formation of a local concentration of the drug and nonspecific transport to tissues that the agent does not precisely target. However, because the physicochemical characteristics of the skin translate to several obstacles and restrictions in transdermal distribution, a significant number of research is required to overcome these bottlenecks. In this study, the many different kinds of available TDDS approaches have been addressed, as well as a critical assessment of their benefits and limits, characterization methods, newly added drugs, and potential. In addition, the present study analyzes the potential of these techniques. The advancement of research into these other technologies has shown the TDDS's high level of efficiency, which has the potential to find applications in a diverse variety of industries.
The Path to Happiness in the “Caucasian” Megatext of Russian Literature (On the Material of A. P. Chekhov’s Short Story “Duel”)
Authors:   Russian State University for the Humanities, Molchanova Diana A.
Published: March 2023

The article focuses on felicitous concepts (interpretations of the essence of happiness and the ways to achieve it) that have taken place in the “caucasian” megatext of Russian literature and have shaped the felicitous paradigm. Several works (“Prisoner of the Caucasus” by A. S. Pushkin, “The Hero of Our Time” by M. Yu. Lermontov, “The Cossacks” by L. N. Tolstoy, “Duel” by A. P. Chekhov) are considered as a polytextual complex of palimpsest type, which reflects the system of characters, complexes of motifs and other essential features of previous texts against the background of the common mythopoetic nature. The article examines the role of the Caucasus as a locus, which has the nature of the “other world,” in the creation of felicitous myths. The semantic presupposition of the Caucasus allows to update the corresponding felicitous meta-plot by including the Caucasus locus in the text. The article considers A. P. Chekhov’s short story “Duel” in the context of the felicitous paradigm, formed on “caucasian” substrate. Summing up the results, it can be concluded that the felicitous paradigm in the “Duel” is transformed, so that the search for happiness coincides with the search for “another self.”
“Taras Bulba”: History and Textology
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Vinogradov Igor A.
Published: March 2023

The article raises the fundamental problems of textual criticism of N. V. Gogol’s story “Taras Bulba.” The author of the article provides an analytical review of the translation and publishing practice of representatives of Ukrainian nationalism of the 19th–20th centuries, the features of the publications of Gogol’s story with textological “innovations” by P. A. Kulish, M. O. Lobodovsky, M. Sadovsky (N. K. Tobilevich), I. A. Malkovich. The distinctive feature of the listed cases is the ideological character of the violation of the fundamental scientific principle of choosing the final wording of the text. The preference for the publication of the early edition of Taras Bulba over the later one leads to the fact that Taras Bulba’s famous speech about partnership, the image of the path of the traitor Andriy to enemies, the words of the Cossacks before death about devotion to faith and homeland, Gogol’s prophecy about Russian tsar and the narrator’s exclamation about the irresistible Russian power became “an appendix” without author’s context. The paper clearly shows the need for a comprehensive, complex solution of textual problems and the inadmissibility of ignoring the last writer’s will.
In Memory of Vera Nikolaevna Anoshkina (Kasatkina)
Authors:   State University of Education, Kiseleva Irina A. , Gulin Alexander V. ,   А.М. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: March 2023

This obituary is dedicated to the talented scientist, researcher of Russian classical literature and experienced teacher Vera Nikolaevna Anoshkina (1929–2023). The authors of the obituary list brief information about the life and academic work of V. N. Anoshkina, talk about the place of her work, her friendship with colleagues from IWL RAS, and their joint activities. The presented text indicates circle of Anoshkina’s scientific interests, especially her increased interest in the axiological sphere of Russian classics, and reports about her pedagogical talent, inexhaustible strength and thirst for an active life. The obituary is accompanied by an excerpt from Anoshkina’s book about the life and work of V. A. Zhukovsky.
“The Crucible of Doubts” of F. M. Dostoevsky and His Heroes
Authors:   Moscow Pedagogical State University, Smyslova Olga N.
Published: March 2023

The review is dedicated to the book by the honorary professor of the University of Nottingham, the famous Russist and dostoevist Malcolm Jones “Dostoevsky and the Dynamics of Religious Experience” (trans. from English by T. Grosheva). The author of the review concentrates on the structure, style and original research methodology consisting in the synthesis of the ideas of M. M. Bakhtin, deconstructivism and “the model of Epstein.” The book by M. Jones offers his own concept of the evolution of Dostoevsky’s and his heroes’ “religious experience,” genetically determined in the tradition of apophatic theology and ascending through doubts and tossing between unconditional faith and nihilistic atheism to a new form of religious consciousness, called “minimal religion” (Epstein’s term). The book under review reveals non-trivial, bold conclusions, sometimes unexpected for Russian literary criticism, about the nature of Dostoevsky’s religious searches, their genesis, evolution and artistic embodiment in later novels.
Heavenly Angel of Mikhail Lermontov (Spiritual Experience as a Creative Category)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Gulin Alexander V.
Published: March 2023

The article is devoted to a comprehensive examination of the religious and moral origins of M. Yu. Lermontov’s creative work. The poetic movement of the great artist can be imagined as the realization and expression of a unique spiritual experience associated with the only in Russian literature in terms of its intensity experience of the Christian thought about the lost heavenly bliss, the ways to find it or the eternal loss in a person’s earthly life. Within this framework the poem “Angel” becomes a kind of “program” that covers the work of Lermontov in all his spiritual range. The article analyzes the ways of returning to the lost harmony with the Creator sung by Lermontov — the heroic service of Heavenly truth (“Borodino,” “Song about Tsar Ivan Vasilyevich…”), the feat of maternal love (“Cossack lullaby”), as well as the poet’s catastrophic experiences of human Godforsakenness (“Meditation,” “Both boring and sad,” “Gratitude”). The novel “A Hero of Our Time” is studied in terms of of the conceptual opposition “boring — fun.” Much attention is given to an attempt to determine the true hierarchy of light and darkness, delight and obscurity in Lermontov’s work, where the height of the spiritual ideal and the perfection of poetic speech ultimately transform the “Pechorinsky” meanings and moods.
In vitro life table of the storage mite Tyrophagus putrescentiae (Acari: Acaridae)
Authors: Murillo Pamela , Aguilar Hugo
Published: March 2023

Introduction: The mite Tyrophagus putrescentiae is a common contaminant of stored products and an important pest in plant tissue culture laboratories, because they diseminate fungi and bacteria. Objective: To describe the reproduction and life table of T. putrescentiae in vitro. Methods: We reared the mites with its associated fungus Leptosphaerulina sp., recording growth and development every 12h. Results: The duration of the egg, larva, protonymph, and tritonymph stages of cohort 1 was 4,52; 1,57; 1,37 and 1,29 days (cohort 2: 4,54; 1,44; 1,31 and 1,45 days, respectively). Cohort 1 periods of pre-oviposition, oviposition and post-oviposition were 1,86; 7,21 and 1,35 days (most cohort 2 individuals did not reach maturity). The intrinsic rate of natural increase (rm) was 0,11 individuals per female per day, the net reproduction rate (Ro) was 29,21; the generation time was 29,47 days, and the finite rate of increase (λ) was 1,12 times per female per day. Conclusion: Under the typical laboratory conditions, T. putrescentiae can multiply its initial population in a single day, which explains the population explosions observed in these laboratories.
Research, publications and knowledge in wildlife research and management
Authors: Willebrand Tomas
Published: March 2023

THIS IS NOT AN ABSTRACT This is not a traditional manuscript and is a
result of my thoughts on wildlife research since NKV decided to start
Wildlife Biology to replace the national journals 30 years ago. I am not
sure that this is a format suitable for Wildlife Biology but it would be
interesting to know what you think. Best wishes, Tomas Willebrand
Introduction of Photopolymerization Technology and Application
Authors: He Xianglong , Zang Liheng , Xin Yangyang , Zou Yingquan
Published: March 2023

Photopolymerization as an energy-saving and environment-friendly
technology has been applied in many fields and developed continuously
since the middle of the 20th century. Today, photopolymerization
technology is ubiquitous in every aspect of our lives. This review
starts from the principle of photopolymerization reaction, introduces
the process of photopolymerization, initiation mechanism of
photoinitiators and three kinds of polymerization methods according to
the wavelength of irradiation source. Subsequently, review focuses on
the application of photopolymerization technology in thiol-based click
reaction, 3D printing, photoresist, hydrogels and other fields, so as to
demonstrate its irreplaceable role in the present.
Efficacy of buffalo dung inhabiting bacteria in biocontrol of vascular wilt and gummosis for luxuriant growth of Foeniculum vulgare Mill.
Authors: DHIMAN SANDHYA , Baliyan Nitin , Maheshwari Dinesh Kumar , Rajput Minakshi
Published: March 2023

In present research, three plant growth-promoting (PGP) non-pathogenic
bacterial strains Proteus mirabilis BUFF12, Pseudomonas
aeruginosa BUFF14 and Enterobacter xiangfangensis BUFF38
inhabiting buffalo dung identified and studied for antifungal activity.
Among three, P. mirabilis showed broad spectrum antifungal activity
against Fusarium oxysporum (62.7%) and Rhizoctonia solani
(71.7%). FTIR spectral analysis of crude ethyl acetate extract of P.
mirabilis showed the presence of O-H, N-H, O=C=O, C=O, C=N, CH2, C-O,
C-H, PO2-, and C-C functional groups. GCMS spectral analysis displayed
the presence of eleven bioactive metabolites and the major compounds
were 2-cyclopenten1-one, 3-(acetyloxy) (23.87%) followed by
Glutarimide, N-(4-ethylphenyl)- (19.34%); 4-methyl-2-oxopentanenitrile
(14.49%); 2,3-Cyclododecenopyridine (13.40%). The purified compounds
also established multifarious PGP activity in test crop plants during
pot study for disease management. 2-cyclopenten-1-one,3-(acetyloxy)
recorded significant inhibitory activity against F. oxysporum
(62.7%), followed by R. solani (71.7%). Pot trial studies with
this strain significantly reduced disease severity in fennel plants
challenged with F. oxysporum and R. solani infection. Our
findings provide new insights into the antifungal activity of P.
mirabilis, and suggest this species may a promising candidate as a
biocontrol agent to confer resistance to gummosis and foot rot and other
phytopathogens in fennel crop.
Particle-In-Cell simulation of electrostatic waves in the ionosphere
Authors: Moulick Rakesh , Adhikari Sayan , Sharma Gunjan , Miloch Wojciech J. , Saikia B. K.
Published: March 2023

In the space atmosphere, plasma with two electron components is very
common. The cold species of electron (Te∼1 eV) usually
originate in the ionosphere, while the hot electron species
(Te∼100 eV) appear from the magnetosphere. In addition to
these two electron species, there may be a beam of electrons streaming
along the magnetic field lines. These electrons are responsible for
exciting various electrostatic wave modes. Several authors have
investigated such a system in the recent past. In this article, we
revisit the problem and provide some more beam energy-based systemic
insights.