bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Quarantine During the COVID-19 Pandemic on The Oral Health Habits of the Syrian Community
Authors: Kazwini Rudwan , Alawad Walaa , Alhaffar MHD Bahaa Aldin , Alomari Haya Doura , Othman Muhamad Abdulaziz , Ebrahim Abedulrahman
Published: November 2021

Introduction: Corona Virus appeared at the end of 2019. It belongs to a large family of viruses that can cause respiratory infections. Due to its ability to spread rapidly and easily, it has become a pandemic throughout almost the entire world. This has necessitated the establishment of quarantine procedures in order to reduce the rate of spread of the virus and thus the number of deaths. However, these procedures may cause a range of effects on people. One of the most important aspects that can be affected is oral health care. This study was conducted to investigate the effect of quarantine procedures on the oral health habits of the Syrian community.Materials and methods:A survey was created using Google Forms and published on Facebook from 16 April 2020 until 11 May 2020. The number of people corresponding to the study criteria in Syria reached 1033. The survey looked at the effect of quarantine procedures on changing oral health habits, including the number of times of brushing and the time of brushing.Results: Quarantine led to a change in oral health habits in 57.4% of the sample. Females were significantly more affected by changing habits during quarantine (P=0.020). The number of brushing times was not clearly affected and it was twice daily (49.4% before quarantine, 42.1% during quarantine). There was no statistically significant difference between the two periods in terms of the number of times of brushing.Conclusion: This study is the first study that showed the effect of home quarantine on the oral habits of members of the Syrian community. Home quarantine did not significantly affect the oral health habits of Syrians.
Self-Supervised Machine Learning Approach for Identifying Biochemical Influences on Protein-Ligand Binding Affinity
Authors: Singh Arjun
Published: November 2021

Drug discovery is incredibly time-consuming and expensive, averaging over 10 years and $985 million per drug. Calculating the binding affinity between a target protein and a ligand is critical for discovering viable drugs. Although supervised machine learning (ML) models can predict binding affinity accurately, they suffer from lack of interpretability and inaccurate feature selection caused by multicollinear data. This study used self-supervised ML to reveal underlying protein-ligand characteristics that strongly influence binding affinity. Protein-ligand 3D models were collected from the PDBBind database and vectorized into 2422 features per complex. LASSO Regression and hierarchical clustering were utilized to minimize multicollinearity between features. Correlation analyses and Autoencoder-based latent space representations were generated to identify features significantly influencing binding affinity. A Generative Adversarial Network was used to simulate ligands with certain counts of a significant feature, and thereby determine the effect of a feature on improving binding affinity with a given target protein. It was found that the CC and CCCN fragment counts in the ligand notably influence binding affinity. Re-pairing proteins with simulated ligands that had higher CC and CCCN fragment counts could increase binding affinity by 34.99-37.62% and 36.83%-36.94%, respectively. This discovery contributes to a more accurate representation of ligand chemistry that can increase the accuracy, explainability, and generalizability of ML models so that they can more reliably identify novel drug candidates. Directions for future work include integrating knowledge on ligand fragments into supervised ML models, examining the effect of CC and CCCN fragments on fragment-based drug design, and employing computational techniques to elucidate the chemical activity of these fragments.
Association Between CLOCK 3111 T/C Polymorphism with Ghrelin, GLP-1, Food Timing, Sleep and Chronotype in Overweight and Obese Iranian Adults
Authors: Rahati Sara , Qorbani Mostafa , Naghavi Anoosh , Nia Milad Heidari , Pishva Hamideh
Published: November 2021

Background

Circadian Locomotor Output Cycles Kaput (CLOCK), an essential element of the positive regulatory arm in the human biological clock, is involved in metabolic regulation. The aim was to investigate the behavioral (sleep duration, food timing, dietary intake, appetite and chronobiologic characteristics) and hormonal (plasma ghrelin and Glucagon-like peptide-1 concentrations) factors that could explain the previously reported association between the CLOCK 3111T/C SNP and obesity.
Methods

This cross-sectional study included 403 subjects, overweight and/or obesity, aged 20- 50 years from Iran. The CLOCK rs1801260 data were measured by the PCR-RFLP method. Dietary intake, food timing, sleep duration, appetite and Chrono-type were assessed using validated questionnaires. Ghrelin and GLP-1 were measured by radioimmunoassay in plasma samples. Participants were also divided into three groups based on rs1801260 genotype and BMI. Logistic regression models and general linear regression models were used to assess the association between CLOCK genotype and study parameters. Univariate linear regression models were used to assess the interaction between CLOCK and VAS, Food timing, chronotype and sleep on food intakes.
Results

After controlling for confounding factors, there was a significant difference between genotypes for physical activity (P=0.001), waist circumference (P˂0.05), BMI (˂0.01), weight (P=0.001), GLP-1 (P= 0.02), ghrelin (P= 0.04), appetite (P˂0.001), chronotype (P˂0.001), sleep (P˂0.001), food timing (P˂0.001), energy (P˂0.05), carbohydrate (P˂0.05) and fat intake (P˂0.001). Our findings also show that people with the minor allele C who ate lunch after 3 PM and breakfast after 9 AM are more prone to obesity (P˂0.05). furthermore, there was significant interactions between C allele carrier group and high appetite on fat intake (Pinteraction=0.041), eat lunch after 3 PM on energy intake (Pinteraction=0.039) and morning type on fat intake (Pinteraction=0.021).
Conclusion

Sleep reduction, changes in ghrelin and GLP-1 levels, changes in eating behaviors and evening preference that characterized CLOCK 3111C can all contribute to obesity. Furthermore, the data demonstrate a clear relationship between the timing of food intake and obesity. Our results support the hypothesis that the influence of the CLOCK gene may extend to a wide range of variables related to human behaviors.
Effect of the Gravel Filters and Plastic Cover on Improving Water Infiltration Process and Increasing Moisture Storage of Rainwater Harvesting Systems in Sloping Lands
Authors: Feng Li , Liu Jiajun , Azamathulla Hazi Mohammad , Youshanlouei Mohammad Mehdizadeh
Published: November 2021

Rainwater harvesting is a suitable method to plant seedlings in sloping lands in arid and semi-arid regions. In this research, a combination of plastic coating and gravel filter has been used to penetrate water into the soil. In this method, water is stored in the soil during the rainy months and the plant uses these waters in the warm months of the year. For this purpose, five treatments (with three replications) including control treatment, system vegetation removal with filter, system vegetation removal without filter, semi-insulated system with filter and semi-insulated system without filter are considered. Two sensors are installed in each of the treatments at a depth of 20 cm and 60 cm of soil, which will record moisture in seven-day periods. Apricot seedlings have been planted in all treatments. The information obtained was analyzed through a completely randomized block design. The results showed that the semi-insulated treatment with gravel filter stored significant moisture in the soil rather than other treatments and stored more moisture in the warm months of the year. The results showed that semi-insulated treatment with gravel filter is a suitable solution to increase soil moisture in the warm months of the year (June, July, August and September).
Behavior of Short Columns Constructed using Engineered Cementitious Composites under Seismic Loads
Authors: Basha Syed Humayun , Lian Xiaoqin , Hou Wei , Zheng Pandeng , Guo Zi-Xiong
Published: November 2021

The present research reports the application of engineered cementitious composites (ECC) as an alternative to conventional concrete to improve the brittle shear behavior of short columns. Experimental and finite element investigation was conducted by testing five reinforced engineered cementitious composite (RECC) concrete columns (half-scale specimens) and one control reinforced concrete (RC) specimen for different shear-span and transverse reinforcement ratios under cyclic lateral loads. RECC specimens with higher shear-span and transverse reinforcement ratios demonstrated a significant effect on the column shear behavior by improving ductility (>5), energy dissipation capacity (1.2 to 4.1 times RC specimen), gradual strength degradation (ultimate drift >3.4%), and altering the failure mode. The self-confinement effect of ECC fibers maintained the integrity in the post-peak region and reserved the transmission of stress through fibers without noticeable degradation in strength. Finite element modelling of RECC specimens was carried out by adopting simplified constitutive material models. It was apprehended that the model simulated the global response (strength and stiffness) with an accuracy of about 95%, and captured the shear and flexure crack patterns reasonably well.
Synthesis and Characterization of Erythromycin Loaded PLGA and PCL Microspheres: Antimicrobial Application
Authors: Bennabi Lamia , Abedelemalek Ilham , Ammari Abedelkader , Sediri Khaldia , Bennabi Fatima , Guemra Kaddour , Belarbi Lahcen
Published: November 2021

We presents in this work the preparation of several formulations, based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly(lactic-co-glycolic) acid (PLGA) loaded with Erythromycin (ERYT) antibiotic. These biocompatible materials were used to prepare microspheres with and without immobilized ERYT via simple evaporation method by simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried-out by Agar diffusion disc method. The results show that PCL/PLGA blend and PCL alone inhibited the strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.
Bioinformatics approaches to investigate the phytochemicals of Centella asiatica against the main protease of SARS-CoV-2
Authors: Khan Md. Arif , Khan Md. Abdullah Al Mamun , Rahman Shahidur , Ahsan Asif , Sanjana Jannatul Maowa , Mahmud Shafi , Mahfuz A M U B , Sharfaraz Ashik , Khan Mobaidul Islam , Emran Abdullah Al , Ahmed Firoz , Moni Mohammad Ali
Published: November 2021

The recent pandemic caused by the novel coronavirus SARS-CoV-2 has impacted global health by increasing mortality and unexpected infection rate. Extensive clinical research is undergoing to repurposing the old drug against this virus. So, this is an emerging need to develop therapy against the virus. Plant-derived natural products have proven to be potent therapeutics for several infections and diseases. Centella asiatica, is a native plant of the Indian subcontinent, has been vastly using as folk medicine against diseases including infectious diseases. So, using bioinformatics approach we identified and checked the phytochemicals of the plant as inhibitors against the main protease (Mpro), the key regulatory enzyme of the SARS-CoV-2 lifecycle. Computer-aided drug designing methods were performed to reveal the best nine drug-like phytochemicals those theoretically have the higher binding affinity of inhibiting Mpro. This outcome may direct to the development of potent therapeutics against the SARS-CoV-2 and demands experimental validation.
How does social security affect people’s subjective wellbeing in China? A chain mediation model
Authors: Li Na , He Mang
Published: November 2021

We utilize data from 2017CSS to explore factors related to people’s subjective wellbeing (SWB). Employing statistical analysis software, we test the chain mediation effect among social security, social fairness, social trust, and SWB. The results show that social security has a direct positive effect on people’s SWB (β = 0.481, p <0.001). Social security also indirectly influences people’s SWB through social fairness and social trust. High quality of social security can enhance the degree of social fairness thereby increasing the level of social trust, finally contributing to higher levels of SWB in China. The total effect of SWB explained is 49% in the chain mediation model. Based on the results, contributions and limitations are discussed in this paper.
Effect of Internet Addiction on Depression among Pakistani Population amidst the COVID 19
Authors: Lakhdir Maryam Pyar Ali , Angez Meher , Nathwani Apsara Ali , Hameed Ayesha Nasir , Khan Malik Muhammad Hamza , Nawaz Muhammad Talha , Peerwani Ghazal , Azam Syed Iqbal
Published: November 2021

Background: Internet addiction has proved to have detrimental effects on the mental health wellbeing of people. During COVID19, these effects are amplified significantly; therefore, this study aims to assess the effect of internet addiction (IA) on the presence of depression among the Pakistani population amidst COVID 19. MethodsA cross-sectional design was employed using an anonymous web-based survey link. This link was disseminated via different social media platforms. The "Young's Internet Addiction Test" (IAT) and "Depression, Anxiety, and Stress Scale-21" (DASS-21) screening tools were used to measure Internet addiction (IA) and level of depression respectively. Adjusted odds ratios along with 95% confidence interval were reported using multinomial logistic regression for the association of IA and other predictors associated with depression. Results A total of 1145 individuals has completed this survey. Overall, the prevalence of severe and extremely severe depression was found to be 9.7% and 16.4% amidst the Pakistani population during the Covid-19 outbreak. The odds of extreme depression were 15 times more among (AIU) addicted internet users (95% CI: 8.26-28.8) and 7 times more among (PIU) problematic internet users (95% CI: 4.57-12.05) as compared to (NIU) normal internet users. ConclusionIn the aftermath of COVID 19, depression was found to be significantly related to internet addiction. This study determined that addicted and problematic internet users are more prone to suffer from depression.
Distributed Energy Efficient Clustering Routing Protocol for Wireless Sensor Networks Using Affinity Propagation And Fuzzy Logic
Authors: Wang Chu-hang , Hu Huang-shui , Zhang Zhi-gang , Guo Yu-xin , Zhang Jin-feng
Published: November 2021

Organizing nodes into clusters and forwarding data to the Base Station (BS) in clustering routing protocols have been widely utilized to improve the energy efficiency, scalability and stability of Wireless Sensor Networks (WSN). Making decisions on how many clusters are formed, which nodes are selected as Cluster Heads (CHs) and who become the relay nodes significantly impact the network performance. Therefore, a Distributed clustering routing protocol combined Affinity Propagation (AP) with Fuzzy Logic called DAPFL is proposed in this paper, which considers not only energy efficiency but also energy balance to extend the network lifetime. In DAPFL, AP is firstly used to determine the number of clusters and select the best CHs simultaneously based on residual energy, distance between nodes. Then the optimal next-hop CHs are chosen by using fuzzy logic system with residual energy, data length and distance to BS as descriptors. Simulations in different scenarios are carried out to verify the effectiveness of DAPFL, and the results show that DAPFL exhibits the promising performance in terms of network energy consumption, standard deviation of residual energy, network throughput and lifetime, compared with the up-to-date distributed clustering routing protocols EEFUC, EEFRP, LEACH-AP and APSA.
AGI Grade-guided Chaiqin Chengqi Decoction Treatment For Predicted Moderately Severe And Severe Acute Pancreatitis (CAP Trial): Study Protocol of a Randomised, Double-blind, Placebo-controlled, Parallel-group, Pragmatic Clinical Trial
Authors: Chen Zhiyao , Yang Xiaonan , Guo Jia , Jin Tao , Lin Ziqi , Zhu Ping , Li Jing , Li Ling , Sun Xin , Du Dan , Jiang Kun , He Yanqiu , Cai Fei , Li Lan , Hu Chen , Tan Qingyuan , Huang Wei , Deng Lihui , Xia Qing
Published: November 2021

Background: Acute pancreatitis (AP) is the common digestive disease with a potentially high risk of mortality. Traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD) has been used for the management of AP in West China Hospital for decades. CQCQD for AP (CAP) trial tests whether the administration of CQCQD will improve the efficacy of the present comprehensive treatments for predicted moderately severe and severe AP.Methods: This is a single-centre, randomised, controlled, double-blind, two-arm pragmatic clinical trial. Eligible patients with a clinical diagnosis of AP will be randomly allocated on a 1:1 basis to CQCQD or placebo control administration based on conventional standard therapy for AP. The administration of CQCQD and placebo are guided by Acute Gastrointestinal Injury (AGI) grade-based algorithm. The primary outcome measure will be the duration of respiratory failure within 28 days after onset. Secondary outcome measures include occurrence of new-onset organ failure and new-onset persistent organ failure, receipt of new organ support therapy, duration of gastrointestinal decompression, requirement of prokinetic agents, duration of fasting, incidence of local complications, requirement for drainage or necrosectomy, hospital length of stay, intensive care unit (ICU) length of stay, cumulative levels of C-reaction protein (CRP) on day 1, 2, 3, 5, 7, 14, 21, 28 after admission, in-hospital cost, all-cause mortality, five-level EuroQol five-dimensional (EQ-5D-5L) questionnaire and so on. Follow-up will be scheduled on 6, 12, and 26 weeks after enrolment.Discussion: The results of this study may provide high-quality evidence of the efficacy of CQCQD in the management of AP. Trial registration: Chictr.org.cn Registry (ChiCTR2000034325). Registered on 2 July, 2020. https://www.chictr.org.cn/showproj.aspx?proj=55591
Long-term Survival Following Palliative Chemoradiotherapy in an Elderly Patient with Advanced Squamous Cell Carcinoma in the Right Mandibular Gingiva
Authors: Ishikawa Yojiro , Umezawa Rei , Yamamoto Takaya , Takahashi Noriyoshi , Takeda Kazuya , Suzuki Yu , Jingu Keiichi
Published: November 2021

Advanced squamous cell carcinoma (SCC) of the mandibular gingiva in elderly patients is difficult to cure. The treatment policy for elderly patients with advanced SCC of the mandibular gingiva has not been clear. We report a case of right mandibular gingival carcinoma that was successfully treated by palliative chemoradiotherapy. An 83-year-old female complained of pain and an ulcer in her right mandibular gingiva. Oral examination revealed a lesion of about 20 mm in size in the right mandibular gingiva. A diagnosis of SCC in the right mandibular gingiva was made by histology. Imaging findings revealed some right neck lymph node metastases. Based on these findings, a clinical diagnosis before treatment was SCC in the right mandibular gingiva (cT4N2bM0, stage IV). She refused to receive definitive surgery or chemoradiotherapy due to concerns about the invasiveness of these definitive therapies and requested palliative chemoradiotherapy. We delivered S-1 (a combination of tegafur, gimeracil, and oteracil) and radiation therapy (RT) to the primary tumor alone with 30 Gy in 10 fractions using 4 megavoltage equipment via a multiple leaf collimator by three-dimensional RT. Although we could not complete the delivery S-1 because of an acute side effect, the palliative chemoradiotherapy resulted in a complete response and the lymph node metastases also disappeared. The patient remains in complete remission 5 years without surgery or chemotherapy. Palliative chemoradiotherapy for elderly patients with mandibular gingival carcinoma is therefore considered to be an effective therapeutic option.
Rice MYB transcription factor OsMYB1R1 negatively regulates drought resistance
Authors: Peng Yan , Tang Ning , Zou Jie , Ran Jing , Chen Xinbo
Published: November 2021

MYB transcription factors have been demonstrated to play an important role in plant growth, development and abiotic stresses. This study isolated a rice MYB gene, OsMYB1R1 (Os04g0583900), and functionally characterized its role in tolerance to drought stress by generating transgenic rice plants with overexpressing (OE) and RNA interference (RNAi) OsMYB1R1 . Expression of OsMYB1R1 was down-regulated by drought stress. The tissue-specific expression analysis indicated that OsMYB1R1 was expressed at high level in panicle, but relatively low in the other parts of rice. No difference in germination rate among OsMYB1R1- OE, RNAi and wild-type (WT) seeds under mannitol treatments. No differences in phenotypes, physiological indicators and agronomic traits among WT, OE and RNAi plants were observed under normal grown conditions. Under drought stress, the RNAi plants were more tolerant to drought stress and higher survival rate after re-watering than WT plants, whereas, the overexpressing plants have found just the opposite. The OsMYB1R1 -OE plants exhibited increased relative electrical conductivity (REC), increased malondialdehyde (MDA) content, and decreased proline content compared with the wild type, whereas lower REC and MDA content and higher proline content were found in the RNAi plants. These results suggest that OsMYB1R1 functions as a negative regulator in response to drought stresses, and may be used as a candidate gene for molecular breeding of drought-tolerant crop varieties.
The Truth, the Whole Truth, and Nothing but the Truth: Therapeutic Privilege
Authors: Shalak Manar , Shariff Masood , Doddapanini Varun , Suleman Natasha
Published: November 2021

The term therapeutic privilege is unfamiliar in the medical field and often sparks questions and discomfort about its ethical implications. Therapeutic privilege refers to the act of withholding of information by a clinician, with the underlying notion that the disclosure of this information would inflict harm or suffering upon the patient1. This is a case of a 56-year-old woman who presented to our facility in critical condition: sepsis with acute respiratory failure requiring intubation and mechanical ventilation. Prior to her admission, her husband had been admitted at our facility and was being cared for in the intensive care unit. On the same day that our patient was extubated, her husband had died. The palliative care team was consulted to assist with disclosing this information to the patient in light of her emotional fragility, her anxiety and concerns for her ability to receive such news given her own active illnesses.
Gender and Feminist Considerations in Artificial Intelligence From a Developing-World Perspective
Authors: Kumar ShailendraIndia , Choudhury Sanghamitra
Published: November 2021

The relationship between women, technology manifestation, and likely prospects in the developing world is discussed in this manuscript. Using India as a case study, the paper goes on to discuss how ontology and epistemology views utilised in AI (Artificial Intelligence) and robotics will affect women's prospects in developing countries. Women in developing countries, notably in South Asia, are perceived as doing domestic work and are underrepresented in high-level professions. They are disproportionately underemployed and face prejudice in the workplace. The purpose of this study is to determine if the introduction of AI would exacerbate the already precarious situation of women in the developing world or if it would serve as a liberating force. While studies on the impact of AI on women have been undertaken in developed countries, there has been less research in developing countries. This manuscript attempts to fill that need.
The Levels of Serum Periostin on the Day of Frozen-thawed Embryo Transfer Affect the Pregnancy Outcomes
Authors: Gu Yuting , Cai Yusen , Li Xiaoyun , Liu Yang , Chen Yanan , Yang Aijun , Li Zewu
Published: November 2021

Background: Periostin is a secretory extracellular protein that has multiple biological roles. It has been confirmed to play a significant role in embryo implantation and development,placental formation. In our study, we aimed to explore whether the levels of serum periostin on the day of frozen-thawed embryo transfer (FET) affected pregnancy outcomes.Methods: This was a retrospective cohort study consisting of 286 frozen-thawed embryo transfer cycles(FETs). According to pregnancy outcomes, the participants were devided into the pregnant group (n=110) and non-pregnant group (n=176). The concentration of serum periostin was determined by enzyme-linked immunosorbent assay (ELISA).Results: In the pregnant group, the level of serum periostin was dramatically higher compared with the non-pregnant group (41.25 ± 25.77 vs. 30.94 ± 18.28 ng/mL; P<0.05). Multivariate logistic regression analysis demonstrated that the level of serum periostin had a significant effect on the clinical pregnancy (OR=1.03, 95% CI: 1.01, 1.04). The receiver operator characteristic (ROC) curve analysis was performed to assess the predictive value of the serum periostin level (AUC 0.61; 95% CI:0.52 ,0.68). Conclusions: In conclusion, the levels of periostin serum on the day of frozen-thawed embryo transfer affected the pregnancy outcomes for patients who underwent frozen thawed embryo transfer.
Assessment of Macular Capillary Perfusion by Optical Coherence Tomography Angiography on Quiescent Unilateral Anterior Pediatric Uveitis
Authors: Xiao Junyan , Qu Yi , Zhao Chan , Song Hang , Liang Anyi , Yang Jingyuan , Zhang Meifen
Published: November 2021

Purpose: Using spectral domain optical coherence tomography angiography (SD-OCTA) to evaluate tomographic and microvascular parameters in the macula in quiescent unilateral anterior pediatric uveitis (APU) patients.Methods: Forty-two eyes of 21 patients diagnosed with unilateral APU and 21 eyes of 21 normal controls (NC) were included in this study. 6*6 mm macular scanning mode of SD-OCTA was used for all subjects. The central macular thickness (CMT), subfoveal choroidal thickness (SFCT), vascular density (VD) of superficial capillary plexus (SCP) and the deep capillary plexus (DCP), the foveal avascular zone (FAZ) area, and choriocapillary flow density (CFD) were analyzed and compared among affected, fellow, and NC eyes. Correlation analysis were used to evaluate the potential correlating factors with CFD.Results: DCP VD and CFD were significantly lower in quiescent affected eyes as compared to fellow and NCs eyes (DCP VD both p<0.001; CDF1.0: p=0.012 and p=0.003; CDF1.5: p=0.015 and p=0.006; CDF3.0: p=0.036 and p=0.010, respectively). SCP VD, DCP VD and CMT were significantly lower in the fellow eyes as compared to NC eyes (p=0.021; p<0.001; p=0.037, respectively); CFD was negatively correlated with FAZ and CMT in affected eyes and fellow eyes. No significant differences were detected in FAZ among the 3 groups (p > .05).Conclusions: As compared to NC eyes, both retinal and choroidal microvasculature were impaired in eyes with quiescent APU; retinal microvasculature in unaffected fellow eyes of unilateral APU was also impaired. OCTA is a useful technology for detection of subclinical microvascular changes in APU and may be useful as an additional prognostic tool.
Die Rolle des α4-Integrins in der Pathophysiologie des Autoimmundiabetes am Modell der spontan diabetischen NOD Maus
Authors:   , Oulghazi Salim
Published: November 2021

Die NOD.α4-/- Maus ist eine auf hämatopoetische Zellen beschränkt α4-inkompetente Maus auf dem NOD Hintergrund. Die Maus ist vollständig gegen Diabetes gefeit, entwickelt keine Insulitis und keine Sialitis. Analysen der α- und ß-Diversität des Mikrobioms zeigen eine vergleichbare Zusammensetzung in NOD.α4-/- und NOD Kontrollmaus, während erkrankte Mäuse ein auffällig eingeschränktes Mikrobiom und atypische Spezies aufweisen. Inselzellantigen-spezifische CD8+ T-Zellen und anti-Insulin-Autoantikörper sind quantitativ stark vermindert im Vergleich zu NOD Kontrollen, jedoch sicher nachweisbar. Das 5-Linien-Differenzialblutbild ist absolut und relativ unauffällig. Die NOD.α4-/- Maus entwickelt nach adoptivem Transfer von CD3+ Zellen diabetischer NOD-Spender mit kurzer Latenz und 100%iger Penetranz Diabetes, ein isolierter Transfer diabetogener CD4+ Zellen ist hierzu nicht hinreichend. α4-kompetente CD8+ Zellen sind also unerlässlich für den adoptiven Transfer von Diabetes in die NOD.α4-/- Maus. Rekonstitution prädiabetischer wildtypischer NOD Empfänger mit NOD.α4-/- Hämatopoese schützt diese zuverlässig vor dem Progress der Insulitis zum Diabetes. Diese Arbeit unterstreicht und sichert die bisherigen α4-Antikörper Studien in der NOD Maus und korrigiert die Annahme, α4-Blockade schütze nicht vor dem Voranschreiten der Sialitis. NOD.a4-/- Lymphozyten werden regelrecht gegen Autoantigene sensibilisiert, in Ermangelung effektiver Infiltration der Zielorgane bleibt jedoch die Expansion antigenspezifischer T-zellen und das Boosten von humoralen Autoimmunantworten aus. α4-inkompetente Leukozyten migrieren auch nach Beginn einer Insulitis oder damit einhergehender Hochregulierung verschiedenster endothelialer Oberflächenproteine nicht in die entzündeten Langerhans-Inseln. Die sichere Prävention der Erkrankung durch Rekonstitution mit α4-/- Hämatopoese identifiziert die α4-Blockade als mögliche Therapie des Typ 1 Diabetes während der Phase des Prädiabetes.
Public health as a basic condition for the socio-economic development of the region
Authors: Гайфуллин А.Н.
Published: November 2021

Социально-экономическое развитие есть планомерная процедура совершенствования уровня жизни, качественных и количественных характеристик, потребляемых общественностью благ. Исходя из ситуации со здоровьем населения в регионе, выставляются соответствующие ориентиры. В разрезе региональной специфики закладываются и реализуются целевые программы, которые одновременно зависят от здоровья населения и направлены, собственно, на улучшение качества его здоровья. Согласно тематике настоящей статьи, ведущий фактор социально-экономического роста - здоровье населения, именно он будет оценен как катализатор искомого регионального развития.

Socio-economic development is a systematic procedure for improving the standard of living, qualitative and quantitative characteristics of the goods consumed by the public. Based on the health situation of the population in the region, appropriate guidelines are set. In the context of regional specifics, targeted programs are being laid and implemented, which at the same time depend on the health of the population and are aimed, in fact, at improving the quality of its health. According to the subject of this article, the leading factor of socio-economic growth is the health of the population, it will be evaluated as a catalyst for the desired regional development.
The influence of universities on the demographic and social development of regions and the labor market
Authors: Данейкин Ю.В. , Иванова О.П. , Зарецкая А.С. , Рожкова А.Ю.
Published: November 2021

В настоящее время нарастает тенденция необходимости включения университетов в решение актуальных задач пространственного, кадрового, социального и технологического развития территорий присутствия. Вузы становятся не только образовательными центрами регионов, они оказывают существенное влияние на изменение общества и внешней среды, как на уровне субъектов федерации, так и на уровне страны в целом. В статье предложена модель методики оценивания вклада университета в социальное и экономическое развитие региона.

Currently, there is a growing tendency of the need to include universities in solving urgent problems of spatial, personnel, social and technological development of the territories of presence. Universities are becoming not only educational centers of the regions; they have a significant impact on changes in society and the external environment, both at the level of the constituent entities of the federation and at the level of the country as a whole. The article proposes a model of the methodology for assessing the contribution of the university to the social and economic development of the region.
Liquefied natural gas as a priority direction for the development of the Russian fuel and energy complex
Authors: Стадник И.В.
Published: November 2021

С каждым годом рынок сжиженного природного газа стремительно развивается и выходит на новые рынки. Российский СПГ не только реализуется на внешнем рынке, но и преобладает на внутреннем. В стране работают одни из крупнейших в мире заводов по производству СПГ. Россия стремится развивать это направление, планируя занять одно из лидирующих позиций среди стран-производителей сжиженного природного газа.

Every year, the liquefied natural gas market is rapidly developing and entering new markets. Russian LNG is not only sold on the foreign market, but also prevails on the domestic market. The country has one of the world's largest LNG production plants. Russia is striving to develop this direction, planning to take one of the leading positions among the countries producing liquefied natural gas.
Increasing financial literacy of the population as an element of the product policy and risk management policy of a commercial bank
Authors: Усов А.С. , Бабина Н.В.
Published: November 2021

Авторами представляется принципиально новый подход к процессу повышения финансовой грамотности россиян - как к элементу продуктовой политики и политики управления рисками коммерческого банка. Сделан вывод о том, что финансовая неграмотность клиента не выгодна банкам, а повышение финансовой грамотности населения имеет исключительно положительные преимущества для всех участников финансового рынка.

The authors present a fundamentally new approach to the process of increasing the financial literacy of Russians - as an element of the product policy and risk management policy of a commercial bank. It is concluded that the financial illiteracy of the client is not beneficial to banks, and the increase in the financial literacy of the population has extremely positive benefits for all participants in the financial market.
Promising technologies for improving the efficiency of specialized aviation and rocket-space communication systems
Authors: Бабин В.С.
Published: November 2021

Развитие авиационных и ракетно-космических систем специальной связи в настоящий момент характеризуется увеличением объемов речевых информационных сообщений. Речь, как наиболее привычная форма общения, позволяет выражать эмоции и личные качества говорящего, чего гораздо сложнее добиться иными путями информационного обмена. Растущий спрос на голосовую связь порождает необходимость выработки перспективных технологий повышения эффективности функционирования таких систем, анализ которых и проведен в данной статье.

The development of aviation and rocket-space systems of special communication is currently characterized by an increase in the volume of speech information messages. Speech, as the most familiar form of communication, allows you to express the emotions and personal qualities of the speaker, which is much more difficult to achieve in other ways of information exchange. The growing demand for voice communication creates the need to develop promising technologies to improve the efficiency of such systems, the analysis of which is carried out in this article.
Nonparametric, statistical analysis of the reliability of satellites and satellite subsystems
Authors: Брусков А.А.
Published: November 2021

Надёжность долгое время признавалась главным качеством для систем космического аппарата. К сожалению, в литературе имеются лишь ограниченные данные об отказах на орбите и статистическом анализе надежности спутников. Для восполнения этого пробела был проведен непараметрический анализ надежности спутников для спутников на околоземной орбите. В этой работе я расширяю статистический анализ надежности спутников и исследую надежность подсистем космических аппаратов. Поскольку набор данных подвергнут цензуре, я широко использую оценщик Каплана-Мейера для расчета функций надежности и получаю доверительные интервалы для непараметрических результатов надежности для каждой подсистемы спутика.

Reliability has long been recognized as the main quality for spacecraft systems. Unfortunately, there is only limited data in the literature on failures in orbit and statistical analysis of the reliability of satellites. To fill this gap, a nonparametric analysis of the reliability of satellites for satellites in near-Earth orbit was carried out. In this work, I expand the statistical analysis of the reliability of satellites and investigate the reliability of spacecraft subsystems. Since the data set is censored, I make extensive use of the Kaplan-Meyer estimator to calculate reliability functions and obtain confidence intervals for nonparametric reliability results for each spootik subsystem.
Physical model of noise in the combustion chamber of a liquid-propellant engine
Authors: Мосалов О.П. , Завьялова Ю.В.
Published: November 2021

В статье рассмотрена задача определения резонансных характеристик камер сгорания жидкостного ракетного двигателя. Приведён и математически обоснован подход к созданию алгоритмов решения такой задачи с помощью анализа спектральной плотности мощности шумовых сигналов параметров рабочих процессов. Рассмотрены вычислительные эксперименты и продемонстрированы их результаты для модельного сигнала с единственной модой.

In this article a task of determining of resonance characteristics for combustion chambers of a liquid rocket engine. The approach for development of algorithms to solve this task using analysis of power spectral density of noise signals of working procedure parameters is considered and mathematically justified. Computational experiments are considered and their results for a model signal with a single mode is demonstrated.
Improving the reliability of the amplification and switching unit of on-board radio telemetry equipment
Authors: Овейчук И.А. , Скворцов Р.В.
Published: November 2021

В настоящей статье представлены научные результаты решения задачи повышения надёжности и технологичности бортовой радиотелеметрической аппаратуры. Рассмотрены 3 варианта решения поставленной задачи и выбран наиболее перспективный - замена ЭРИ на источники вторичного питания. Данный метод показал наиболее высокие характеристики по сравнению с аналогичными методами. Приведённые расчёты наглядно показывают эффективность предложенного метода.

This article presents the scientific results of improving the reliability and manufacturability of on-board radio telemetry equipment. We considered 3 variants of the solution of the task and choose the most promising - the replacement of radio elements with secondary power sources. This method demonstrates the highest characteristics compared to similar methods. The above calculation clearly demonstrates the effectiveness of the proposed method.
Implementing Massively Parallel Architecture in a Web Service
Authors: Аббасова Т.С.
Published: November 2021

Проанализированы пути снижения времени выполнения запроса к web-сервису от базы данных. Разработана схема массово-параллельной архитектуры для повышения показателя скорости приёма и обработки информации. Изменена система организации потоков информации, применён новый тип системы хранения информации. Предложены аналитические соотношения для определения снижения времени обращения к веб-сервису хранилища данных.

The ways of reducing the execution time of a request to a web service from a database are analyzed. A scheme of massively parallel architecture has been developed to increase the rate of information reception and processing. The system for organizing information flows has been changed, a new type of information storage system has been applied. Analytical relationships are proposed to determine the reduction in the access time to the data warehouse web service.
Financial depth-economic growth nexus: Implications for the Ukrainian banking sector
Authors: Kerimov Pavlo
Published: November 2021

The relevance of this study is warranted by changes in the modern understanding of the interrelation between economic growth and financial depth. While earlier studies consider it to be universally positive, newer ones tend to challenge both nature and direction of such a relationship. This paper aims to investigate the nature of the financial depth-economic growth nexus in Ukraine during 2008–2019 based on data provided by the State Statistics Committee of Ukraine and the National Bank of Ukraine, using the standard OLS regression. The resulting model with an adjusted R squared of 0,96 confirms a strong (within a 90% confidence interval) linear relationship between real GDP per capita, denominated in local currency, which was used as a proxy for economic growth, and financial depth, which was assessed using three indicators: the share of bank loans to non-financial institutions in real GDP, the share of non-bank loans to non-financial institutions in real GDP, and the share of stock market capitalization in real GDP. Both bank and non-bank loans to real GDP ratios have a negative impact on economic growth (UAH 2,154 and UAH 78,154 decline per 1% growth, respectively), while market capitalization provides a positive influence (UAH 1,641,130 growth per 1% growth). This implies that, despite concentrating the majority of the resources available to the Ukrainian financial sector, the banking sector does not contribute to its economic growth. This can be alleviated by imposing additional restrictions on the amount of government securities allowed in a bank’s capital structure.
AcknowledgmentsThe paper was funded as a part of the “Relationship between financial depth and economic growth in Ukraine” research project (No. 0121U110766), conducted at the State Institution “Institute for Economics and Forecasting of the NAS of Ukraine”.
AS INTERVENÇÕES DO PIM COMO OBJETO DE ANÁLISE
Authors: Almeida Fernanda Dias , De Carvalho Fernanda Antoniolo Hammes , Barlem Edison Luis Devos
Published: November 2021

A primeira infância, considerando-se do nascimento aos 7 anos de idade, necessita de cuidados essenciais para o desenvolvimento saudável da criança, trazendo dessa forma impactos socioeconômicos à sociedade. Quanto às políticas públicas, são imprescindíveis programas que estimulem atividades relacionadas ao desenvolvimento integral dessa fase da vida, contribuindo para otimizar o desenvolvimento cognitivo e socioemocional das crianças. Neste sentido, o Programa Primeira Infância Melhor (PIM), criado pelo Governo do Estado do Rio Grande do Sul e coordenado pela Secretaria da Saúde do Estado e com apoio das Secretarias de Cultura, Educação, Trabalho e Desenvolvimento Social, é política de governo que atende famílias vulneráveis com gestantes e crianças de 0-3 anos, encaminhadas, em especial, pela UBSF. Crianças egressas de Unidade de Tratamento Intensivo (UTI) também compõem esse público-alvo e requerem atenção especial. Considerando que a produção científica, além de promover a divulgação de uma política pública, paralelamente contribui para análise, reflexão e discussão de programas, o que colabora para a qualificação das ações envolvidas, o artigo aqui apresentado tem como objetivo gerar um panorama da produção científica nacional que tem como temática a abordagem dessa Política Pública.
A EVOLUÇÃO BIOLÓGICA À LUZ DA CULTURA CIENTÍFICA E HISTÓRIA DA CIÊNCIA EM LIVROS DIDÁTICOS DO ENSINO MÉDIO (PNLD, 2015)
Authors: Assad Beatriz Marques , Giese de Paula Machado Rebekah , Ruthieri Saturno da Silva Evander
Published: November 2021

O estudo da evolução biológica é considerado um dos principais eixos que unificam os conhecimentos no ensino de Ciências e Biologia. Porém, no cenário mundial o ensino desta temática enfrenta diversos desafios. O livro didático, na educação básica brasileira, é um dos principais, senão o único, material pedagógico utilizado. Desse modo, foram selecionados como objeto de estudo deste trabalho os três livros didáticos de Biologia com os maiores índices de distribuição no território nacional (PNLD 2015), nos quais analisou-se o conteúdo de evolução biológica quanto à presença de elementos caracterizados como História da Ciência e de cultura científica. As três obras didáticas incluíram o conteúdo esperado, conforme os parâmetros da DCNEM e BNCC e divergiram quanto à visibilidade de determinados temas. Além disso, todos os livros apresentaram elementos de História da Ciência e cultura científica. Contudo, poderiam estar melhor desenvolvidos ao longo dos textos principais, visto que a ocorrência de cultura científica se deu majoritariamente nos conteúdos compreendidos em sessões extras do livro. Portanto, conclui-se que os três livros são recursos didáticos adequados para auxiliar o professor no ensino de evolução biológica, porém, insuficientes para obtenção de uma visão crítica da ciência.
COMPREENSÕES DE LICENCIANDOS SOBRE A SUPERAÇÃO DAS DIFICULDADES DE APRENDIZAGEM NO ENSINO FUNDAMENTAL
Authors: Alves José Moysés , Bezerra Hanna Patrícia da Silva , Ribeiro Rosineide Almeida
Published: November 2021

A maneira como os licenciandos compreendem as dificuldades de aprendizagem e sua superação pode contribuir para a construção de alternativas ao ensino conteudista e à medicalização do problema. O presente artigo relata uma pesquisa sobre a própria prática de três professores formadores, em uma turma de 22 licenciandos, no tema Compreensão e Explicação dos Processos de Desenvolvimento e Aprendizagem II. A superação das dificuldades de aprendizagem foi um dos assuntos estudados, a partir da visão da teoria da subjetividade. Analisamos produções escritas dos licenciandos em diferentes momentos de uma sequência didática, ao responderem questões de estudo, analisarem um filme e relatarem observações do estágio. Avaliamos a compreensão dos licenciandos sobre as ideias dos textos e as relações que eles produziram entre estes conceitos e situações práticas. Os resultados indicam que a sequência didática favoreceu a compreensão das ideias e a articulação teoria e prática. Entretanto, consideramos que teorias implícitas dos licenciandos dificultam a aprendizagem dos conceitos da teoria da subjetividade. Estes resultados sugerem possibilidades de mudanças na estratégia didática dos professores formadores e a realização de outras pesquisas de acordo com o referencial da teoria da subjetividade e da epistemologia qualitativa.