bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of Janus kinase selective inhibitors in the treatment of atopic dermatitis: A systematic review and meta-analysis
Authors: Wang Mingyue , Gao Xinghua , Zhang Li
Published: February 2025

Background: Although previous studies have confirmed that Janus kinase (JAK) inhibitors have good efficacy and safety in the treatment of atopic dermatitis, the U.S. Food and Drug Administration has issued a black box warning for all JAKs. Therefore, it is necessary for us
to further pay attention to their safety. Method: The medical literature data bases were searched from database creation until August 26, 2023. Randomized controlled trials of moderate-to-severe atopic dermatitis treated with JAK1-selective inhibitors (upadacitinib and
abrocitinib) were included. Results: In this meta-analysis, which included 12 studies (one of which reported two outcomes), we collected data at 2, 4, 8, 12, and 16 weeks. Almost all results showed that JAK1-selective inhibitors were more efficacious than controls and had
an onset of action at week 2. There was no significant difference in the incidence of serious adverse events and adverse events, leading to discontinuation, whereas, for treatment-associated adverse events, the JAK1-selective inhibitors were higher than the control group (RR 1.16 [95% confidence
interval, 1.11‐1.21]; p < 0.00001). Conclusion: Overall, the treatment of atopic dermatitis with JAK1-selective inhibitors has a rapid onset of action. However, we need to be aware of the treatment-associated adverse events, more studies need to
be conducted to provide better decisions on clinical medications for patients with moderate-to-severe atopic dermatitis.
Association of exposure to ambient particulate matter with asthma in children: Systematic review and meta-analysis
Authors: Ke Ximeng , Liu Shaodong , Wang Xue , You Jinlong , Zhang Wei , Wang Li , Ge Long , Wang Minzhen , Zheng Shan
Published: February 2025

Objective: To assess the association between airborne particulate matter (PM) exposure and the development of asthma in children, a systematic review and meta-analysis that included nearly 10 years of related literature was conducted. Study Design: The
study investigators conducted a systematic review of relevant research articles published between March 2013 and March 2023, which were accessible through several medical literature data bases of. Random-effects meta-analyses were used to analyze the effects of PM on childhood asthma. Subgroup
analyses, including exposure period, type of PM, regional factors, and study type, were also used. Odds ratio (OR) and 95% confidence intervals (CI) were used to represent the estimated effect of the population. Publication bias was assessed by using the Egger test and funnel plot. Data analyses
were performed using statistical analysis software and a systematic review management tool. Results: A total of 15,365 articles were identified, of which 19 studies were included in this meta-analysis. The results showed that PM exposure was positively correlated with asthma
in children, with the overall random-effects risk estimates of OR 1.10 (95% CI, 1.07‐1.13). In stratified analyses, PM exposure was found to be a risk factor for the development of childhood asthma. Both prenatal and postnatal PM exposure were associated with an increased risk of asthma
in children, but prenatal exposure was associated with a greater increase in risk than postnatal exposure, with an effect estimate OR of 1.21 (95% CI, 1.02‐1.43). In the analysis of different PM types, the OR of PM2.5 (PM < 2.5 μm in diameter) exposure was OR 1.10 (95%
CI, 1.05‐1.15), and no association was found between PM10 (PM < 10 μm in diameter), coarse PM (PM with an aerodynamic diameter between 2.5 and 10 μm), and black carbon BC (diameter of 0.01‐0.05 μm) exposure. In different regional analyses, the effects of
PM exposure on childhood asthma risk were OR 1.15 (95% CI, 1.13‐1.17) in South America and OR 1.02 (95% CI, 1.01‐1.03) in Asia, but no association was found in Europe and North America. In addition, the results of different study types only found that the literature that used
the time-series research method had a significant association with OR 1.03 (95% CI, 1.02‐1.04), whereas the literature that used the cohort study method had no statistical difference. Conclusion: Exposure to airborne PM increased the risk of asthma in children. Both
prenatal and postnatal PM exposure was associated with an increased risk of childhood asthma, but prenatal PM exposure was associated with a greater increase than postnatal PM exposure.
Influence of aeroallergen sensitization and nasal polyposis on mepolizumab response in eosinophilic severe asthma
Authors: Akkus Fatma Arzu , Colkesen Fatih , Onalan Tugba , Evcen Recep , Gerek Mehmet Emin , Kilinc Mehmet , Sadi Aykan Filiz , Arslan Sevket
Published: February 2025

Background: Studies on the impact of comorbidities on treatment responses in severe eosinophilic asthma (SEA) are limited. This study was a real-world investigation into how the presence or absence of nasal polyps (NP) and sensitivity to aeroallergens influence the outcomes
of mepolizumab therapy. Methods: In this retrospective study, data obtained from patients with SEA and who received at least 6 months of mepolizumab treatment were analyzed. The patients were initially divided into two groups based on the presence of NPs. Within these two
groups, the patients were further categorized into subgroups according to the presence of aeroallergen sensitivity (AE). Asthma-related outcomes in the resulting four groups were evaluated both before mepolizumab treatment and during the follow-up period. Results: Among
the 36 patients with NPs, 14 (38.8%) had AE (NP+AE+), whereas 22 (61.2%) did not (NP+AE‐). Of the 35 patients without NPs, 17 (48.5%) had AE (NP‐AE+), and 18 (51.5%) did not (NP‐AE‐). The presence of NPs, independent of AE, was significantly associated with an increase
in asthma exacerbations and oral corticosteroid (OCS) use before treatment (p < 0.001). In the NP+AE+ group, the baseline Asthma Control Test (ACT) score was lower, and the number of hospitalizations was significantly higher (p < 0.001). After mepolizumab treatment, all four groups showed
significant reductions in asthma-related exacerbations, hospitalizations, and OCS use. Furthermore, ACT scores and pulmonary function test parameters significantly improved. There were limited differences in asthma improvements among the groups, with the NP+AE+ group showing a significant
increase in ACT scores and a reduction in hospitalizations compared with the other groups (p < 0.001). Conclusion: Mepolizumab significantly reduced asthma exacerbations, hospitalizations, and OCS use in the patients with SEA with four different phenotypes. Analysis
of these findings suggests that mepolizumab provides real-world benefits regardless of the presence or absence of NPs and AE.
Early clinical improvement of anosmia and sinus nitric oxide in chronic rhinosinusitis with nasal polyps subjects treated with dupilumab
Authors: Lanz Miguel J. , Eisenlohr Claudia P. , Cepeda Lianet Herrera
Published: February 2025

Background/Objective: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have a high morbidity of anosmia, yet there are few noninvasive biomarkers to measure treatment response. Nitric oxide (NO) is found in the paranasal sinuses at 100 times higher levels than
in the lungs and is vital for antimicrobial and/or mucociliary activities and vasodilatory properties. Dupilumab has been shown to improve anosmia in 2 weeks as measured by the University of Pennsylvania Smell Identification Test (UPSIT), 22-item Sinonasal Outcome Test (SNOT-22), and Loss
of Smell (LoS) scoring. We examined the use of NO in various collection methods to monitor anosmia improvement with dupilumab treatment. Methods: Adults with CRSwNP confirmed by computer tomography or endoscopy consented to receive dupilumab 300 mg every two weeks for 16
weeks. Subjects with polyposis despite treatment with steroids and/or a history of sinus surgery were recruited. Measurements of sinus NO (sNO) from the nostril while humming, nasal NO (nNO) while breath-holding, and fractional exhaled nitric oxide (FeNO) while exhaling were collected at baseline
and at 1, 2, 4, 8, 12, 16 weeks. Olfactory impairment was measured by using the UPSIT, SNOT-22, and LoS scoring at every visit. Results: Sixteen adults, with a mean (range) age of 43 years (25‐53 years) were predominantly women (12/16). Baseline mean (range) sNO
values of 434 ppb (203‐665 ppb) significantly increased at 2 weeks to a mean (range) of 1150 ppb (684‐1616 ppb) (p < 0.05). Significant improvements in the UPSIT, SNOT-22, and LoS scores were found at 2 weeks; a weak correlation of the sNO level with the UPSIT and SNOT-22
scores was noted. No significant changes in the FeNO or nNO values were found. Significant improvement was found specifically with anosmia by the end of 2 weeks. Conclusion: Our small pilot study revealed increased sNO levels in the sinuses as early as 2 weeks after the
initial dupilumab administration. Thus, in patients with CRSwNP without asthma, the sNO value has the potential to be used as a noninvasive, objective biomarker for early treatment improvement in anosmia.
Bodies, Natures, Origins
Authors: Bresalier Michael
Published: February 2025

In a short, prescient discussion towards the end of the first volume of The History of Sexuality, Michel Foucault considers the appearance of biopolitics within the domains of Western modernity. [...]
Power in the Spatialization of the American Landscape
Authors: Carragee Kelly
Published: February 2025

The "expedition" is an even which reveals the extent to which the development of scientific disciplines. particularly geographical and anthropological modes of representation which developed during the so-called "Age of Exploration", was a corollary of such projects of domination as European imperialism and later American expansionism. In this paper I describe the process by which the American West was construed as a "natural" space.
[...]
The Non-Science Science of Complexity Theory
Authors: Letts Guy
Published: February 2025

In pre-Enlightenment, nature people were seen as being the determined creation of a divine God. The Aristotelian-Christian world view believed that the world was hierarchically ordered wherein everything had a rightful place and purpose in a divinely created and ordered universe. The Enlightenment challenged this view asserting that the world existed as part of a system that obeyed "natural laws." What was fundamental to the scientific view of the Enlightenment was the strong link it made between reason (represented by humanity) and nature (everything outside of the socio-cultural realm). The Enlightenment concept of nature stressed that the universe was a mechanical system comprised of matter that was in constant motion, which followed the physical laws of nature. [...]
Boundary Work in Regulatory Controversies
Authors: Nigge Karl-Michael
Published: February 2025

The regulation of technological risks is an area in which science and policy are generally linked in an inextricable fashion that Wynne aptly describes through the metaphor of the "regulatory jungle" (1992a). It involves a mixture of scientific, political and ethical issues, and due to the presence of scientific uncertainty on a significant scale, even the scientific issues cannot be answered by scientific means alone, but rely on policy considerations for their resolution. Seen from this perspective, controversies over technological risks come as no surprise.
[...]
Inside the Hall of Silence (a biostratigraphically correct poem )
Authors: Beyers Joanna
Published: February 2025

1. South of Sidney, BC
Time is the sculpted element.In this moment, opposite the rockthat is James Island[...]
Mattering
Authors: Hughes Sheila Hassell
Published: February 2025

I am not emptya place abandonedand subject to squatters' rights
[...]
the thorn
Authors: Richardson Lisa
Published: February 2025

it seems like sacrilegefor a manwith hands gnarled like a jack pine,cracked and knotty,to be holding the garden sylphs.
[...]
Purple Loosestrife and the "Bounding" of Nature in North American Wetlands
Authors: Sandlos John
Published: February 2025

One of the more well known themes among the Christian parables is the separation of the righteous and pure from the impure and the unholy. In one notable example, Christ recounts the experience of a farmer whose enemies have come in the night to plant weeds in his wheat field. [...]
Outward Bound
Authors: Hughes Sheila Hassell
Published: February 2025

I could choose to rest, to glory inthe smooth glacial slopes of isolationmy form reflected on the arctic's deepI could abide on ice floes glowing[...]
Culture, Cash, Congressional Clash
Authors: Teevan Derek
Published: February 2025

In the fall of 1995 there was a proposal before the American congress to open the Arctic National Wildlife Refuge to development. [...]
Coyote Catches the Light
Authors: Sandlos John
Published: February 2025

Coyote came down from the mountainswalked over the hillscame to the edge of the mesa
[...]
Application of Google Earth Engine to Estimate the Water Capacity of Saigon–Dongnai Basin in the Period of 2005–2023 Using MODIS and CHIRPS Satellite Data
Authors: Trong Dieu Hien Le , Le Tan Dat Nguyen
Published: February 2025

This study used the Google Earth Engine (GEE) platform to calculate the water capacity of the Saigon-Dongnai basin using remote sensing-derived products related to evapotranspiration (ET) and precipitation (P). The GEE was used to retrieve two important inputs: MODIS evapotranspiration spanning the drainage basin and CHIRPS satellite precipitation. We found that there was a net decrease in the water capacity from January to April every year as a result of greater evaporation and less precipitation. Due to the increase of precipitation from May to October following the decrease of solar radiation, and the drop in temperature, the rainy season imposed the highest values of the change in water capacity. Rainfall and evapotranspiration show a positive association, as does the relationship between water capacity and inputting water.
Pengembangan Sistem Manajemen Sarana Dan Prasarana, IT, Serta Laboratorium Di SMK Telekomunikasi
Authors: Putri Nabella  , Rudy Herteno  , Setyo Wahyu Saputro  , Friska Abadi  , Muhammad Itqan Mazdadi
Published: February 2025

Bidang Sarana dan Prasarana, IT, serta Laboratorium di SMK Telekomunikasi menghadapi tantangan dalam pengelolaan data yang tersebar di berbagai file Microsoft Excel, menyebabkan kesulitan dalam pengumpulan laporan untuk audit dan sertifikasi. Penelitian ini bertujuan mengembangkan sistem manajemen terpadu menggunakan framework CodeIgniter 4, PHP, dan MySQL dengan metode Rational Unified Process (RUP) dan desain Unified Modelling Language (UML). Sistem ini dirancang untuk menyelaraskan pengelolaan data dan memfasilitasi penyajian informasi yang efisien. Hasil pengujian black box menunjukkan tingkat keberhasilan 100%, sementara user acceptance testing memperoleh skor 92% dengan predikat sangat baik. Implementasi sistem ini diharapkan meningkatkan efisiensi dan efektivitas manajemen sarana, prasarana, IT, dan laboratorium di SMK Telekomunikasi, memberikan kontribusi signifikan terhadap peningkatan kualitas pengelolaan dan kepuasan pengguna.
 
Abstract.
The Facilities and Infrastructure, IT, and Laboratory Department at SMK Telekomunikasi faces challenges in managing data scattered across various Microsoft Excel files, resulting in difficulties in compiling reports for audits and certifications. This research aims to develop an integrated management system using the CodeIgniter 4 framework, PHP, and MySQL, employing the Rational Unified Process (RUP) methodology and Unified Modelling Language (UML) design. This system is designed to streamline data management and facilitate efficient information presentation. The results of the black box testing showed a success rate of 100%, while the user acceptance testing scored 92% with an excellent rating. The implementation of this system is expected to enhance the efficiency and effectiveness of managing facilities, infrastructure, IT, and laboratories at SMK Telekomunikasi, significantly contributing to improved management quality and user satisfaction.
ПАМ’ЯТІ УМАНСЬКОГО БОТАНІКА ВАКАР ТЕТЯНИ БОРИСІВНИ (01.11.1943–10.05.2010)
Authors: Mamchur T. V. , Parubok M. I. , Fitkalenko M. M.
Published: February 2025

The article, based on archival materials, presents the biographical profile of Tetiana Borysivna Vakar (01.11.1943–10.05.2010), a prominent botanist from Uman, Candidate of Agricultural Sciences, Associate Professor, and Head of the Department of Botany at the Uman Agricultural Institute (now Uman National University of Horticulture).
The article explores the life, scientific contributions, and teaching career of T. B. Vakar, who played a pivotal role in the advancement of scientific research and education within the Department of Botany. Her primary research interests lay in botany.
T. B. Vakar’s passion for plants was nurtured from childhood by her father, Professor Borys Anatoliiovych Vakar, a Doctor of Biological Sciences and a leading figure in botany. As the head of a botanical department, he mentored his daughter, who progressed from assistant to associate professor, working alongside him in various agricultural institutes. Over the years, she developed as both a teacher and a scientist, enriching her practical and theoretical knowledge of flora and passing it on to her students.
Her family's extensive travels exposed her to diverse floral ecosystems, enhancing her scientific expertise in plant identification and taxonomy. This exposure further refined her research skills. Eventually, Ukraine became the final destination of her professional journey. The rich botanical diversity of Uman, its surroundings, and the remarkable dendrological collections of the Sofiivka Arboretum, adjacent to the Uman Agricultural Institute, profoundly influenced and inspired her work.
Teaching remained the cornerstone of T. B. Vakar’s career. Her lectures, laboratory classes, and field practices were distinguished by scientific rigor and pedagogical excellence. For years, she conducted botanical excursions with her students, actively engaging them in the study of local flora. She documented her research findings in numerous scientific publications.
According to colleagues and students, Tetiana Borysivna was recognized as a highly skilled botanist, a dedicated educator, and a committed researcher. She consistently integrated theoretical knowledge with practical applications in agricultural production while continuously enhancing her professional expertise.
As head of the Department of Botany, she significantly contributed to strengthening the department’s infrastructure, enriching the plant collections of the Botanical Nursery and Herbarium (UM). These collections, now part of the university’s scientific and educational legacy, continue to serve as valuable resources for research and learning.
Tetiana Borysivna was widely respected for her professionalism, discipline, and high standards. She maintained tolerance and fairness, holding both herself and her colleagues to exacting standards. Her dedication to botany and education left a lasting impact on the academic and scientific community of Uman.
An Analysis of Illocutionary Acts in The Inside Out 2 Animated Movie
Authors: Sianipar Wiwin Lusiana , Pangaribuan Rotua Elfrida , Sembiring Rony Arahta
Published: February 2025

Illocutionary acts play a crucial role in conveying meaning and expressing certain intentions in communication. This study analyzes the use of illocutionary act in the Inside Out 2 animated movie to understand how the characters use their utterances to achieve their intentions and goals. The purpose of this study is to identify the types of illocutionary acts and to analyze the dominant type of illocutionary act in the character’s utterannces in the movie. This study used descriptive qualitative method. The data were collected by transcribing the dialogues and classifying the types of illocutionary acts based on Searle’s (1979) theory, which includes representative, directive, commissive, expressive, and declarative. The findings reveal that there are 320 total data and representative is the dominant type with 133 data (41%), which indicates that each character in the movie tends to informing, describing, claiming, clarifying, or agreeing. The second most frequently used is directive with 102 data (32%), followed by expressive with 61 data (19%), then commissive with 22 data (7%) and declarative with 2 data (1%) as the lowest. This study concludes that illocutionary acts in this movie can be interpreted into five types of intentions. The writer recommends this study can be used as a reference for the learning about illocutionary acts or as a reference for the similiar study with a different perspective.
Directive Speech Act Performed by Male and Female Speakers’ in Ted Talk Language Learning Videos
Authors: Husnan Donni , Kustanti Dewi , Fauzi Erfan Muhammad
Published: February 2025

This study analyzes the use of directive speech acts in TED Talk language learning videos through a pragmatic approach, focusing on orders and suggestions as primary categories. The research examines the speeches of four speakers Matyas Pilin, Chris Lonsdale Lydia Machova, and Marianna Pascal to understand how their speech styles influence the delivery of language learning strategies. This research employed a descriptive qualitative method with purposive sampling data collection. From the 273 data that the author found, 47 data of utterances were selected from four different videos for analysis. The findings reveal that male speakers predominantly use orders, emphasizing a structured and authoritative instructional approach, while female speakers favor suggestions, promoting a supportive and motivational teaching style. This balance between orders and suggestions highlights the diverse strategies employed to address both cognitive and emotional aspects of learners. This study contributes to the fields of pragmatics and educational communication by demonstrating how directive speech acts influence instructional effectiveness. The findings provide valuable insights for educators, linguists, and public speakers in developing more impactful and learner-centered teaching methods. Moreover, the study offers a foundation for further research into the interplay of speech acts, instructional strategies, and cultural or contextual influences in educational settings.
Critical Discourse Analysis in News Media Between the Guardian and Al Arabiya News Website in Israel-Palestine Conflict
Authors: Damayanti Fahnarul , Setyawan Agustinus Hary
Published: February 2025

Nowadays, conflict between two nations become a hot topic worldwide. Israel-Palestine conflict is one of that. On 7th October 2023, Hamas attacked Israel and become a headline in every news media. Currently, media has important role to give information to people around the world. This research using Critical Discourse Analysis. The data was taken from The Guardian and Al Arabiya news website in October 2023 edition. This research uses descriptive qualitative research design. The data were analyses using Van Dijk’s approach focusing on macrostructure, microstructure, and the ideology between two news media. The findings show that both news media talk about Hamas attacked Israel. Israel was portrayed positively as victim and Hamas was portrayed negatively as a threat. It shows that The Guardian and Al Arabiya are more pro-Israel than Palestine. The researcher suggests to do more deeply between The Guardian and Al Arabiya.
The Represenatation of Female Beauty Standard on The Movie "Tall Girl": A Critical Discourse Analysis
Authors: Azhari Firzana Maritza
Published: February 2025

Representing women's beauty standards in the media significantly shapes people's views on self-esteem. This research is essential to understand how the media reveals a narrow definition of beauty standards. This research analyses the representation of female beauty standard of a main female character on a movie using critical discourse analysis by Sara Mills’ theory. The movie “Tall Girl” served as the data source of this research. The data were analyzed with a qualitative approach through documentation, observation, and note taking and validated by expert judgment to determine the theory of feminism by revealing two research objectives: (1) how is the main female character views the beauty standards from the language used and (2) how is the main female character depicted from the language used in the movie. The findings and discussion of this research revealed that Jodi Kreyman, as the main character, transforms the position of an object of bullying to that of a subject who can accept her physical appearance. In addition, from the reader's position, the film allows the reader to empathize with Jodi's struggle and think more critically about the broader standards of female beauty. In conclusion, the movie challenges narrow beauty standards and demonstrates the importance of self-acceptance. Future research could analyze similar issues or the audience's perspectives on female beauty standards to create new insight.
Politeness Principles in “Murder On The Orient Express” Film: A Pragmatic Study
Authors: Nabila Isma , Heryono Heri
Published: February 2025

This research examines the application of the principle of politeness in the film "Murder on the Orient Express" using a pragmatic approach. This study analyzes how each dialogue spoken by the characters in the film can be defined as part of the principle of politeness maxims proposed by Geoffrey Leech. There are 6 maxims of politeness principles, namely the maxim of tact, the maxim of generosity, the maxim of agreement, the maxim of politeness, the maxim of agreement, and the maxim of sympathy. Of all these maxims, this study analyzes the order in which these maxims appear in the dialogue conversations in this film, along with possible reasons. The research method used by the author in this study is a qualitative descriptive research method that can examine evidence of the emergence of speech that implies the principles of politeness maxims in it. In this study, the author found (2) maxims of tact, (5) maxims of generosity, (9) maxims of agreement, (8) maxims of politeness, (6) maxims of agreement, and (3) maxims of sympathy. In conclusion, this study demonstrates the relevance of politeness principles in understanding communication dynamics in a fictional context, highlighting how these principles contribute to character development and plot development. Further research is recommended to explore the application of politeness principles across cultures in film and other media.
STUDY OF WASTEWATER TREATMENT FROM THE PROCESS OF CULTIVATING METHANE-OXIDIZING MICROORGANISMS USING GRANULAR AEROBIC SLUDGE IN SBR
Authors:   Mendeleev University of Chemical Technology, Moscow, Sakayan D.I. ,   Institute of Environmental Engineering, Peoples Friendship University of Russia, Moscow, Kalenov S.V. , Khokhlachev N.S. , Romanovskaya K.S.
Published: February 2025

Studies have been carried out on the efficiency of purification of model wastewater and wastewater from the process of cultivating methane-oxidizing microorganisms. Problems of wastewater treatment from the process of cultivating methane-oxidizing microorganisms are noted, associated with an unbalanced composition of the main nutrients and suboptimal pH values for the processes
of nitrification and denitrification, and high concentrations of heavy metals.
STUDY OF THE EFFECT OF ADDING HERMETIA ILLUCENS LARVAE AND SUNFLOWER OIL TO THE NUTRIENT MEDIUM ON THE GROWTH OF BIOMASS OF CORDYCEPS FUNGI
Authors:   Tomsk State University, Saraev G.I. , Marchenko R.D. , Kuskova I.S. ,   Аrtlife, LLC, Tomsk
Published: February 2025

Submerged cultivation is one of the methods for obtaining biomass of Cordyceps fungi for the needs of the biologically active
substances industry. The choice of optimal cultivation conditions plays a decisive role in this case. This paper examines the effect of
adding sunflower oil and Hermetia illucens fly larvae to the nutrient medium for cultivating Ophiocordyceps sinensis and Cordyceps
militaris on the growth of fungal biomass.
SIGNIFICANCE OF ANTIBODY DETECTION TO B-CELL DETERMINANTS OF ENVELOPE PROTEINS OF HEPATITIS C VIRUS
Authors:   Lomonosov Institute of Fine Chemical Technologies, Moscow, Stuchinskaya M.D. , Nikolaeva L.I. , Shastina N.S. ,   Gamaleya National Research Center for Epidemiology and Microbiology, Moscow
Published: February 2025

The aim of the study was to analyze infected human antibody response to peptides reproducing B-cell epitopes of HCV envelope proteins to assess their possible association with virus elimination. The synthesis of peptides was carried out by the solid phase
method. According to the results of enzyme-linked immunosorbent assay, it was found that the presence of antibodies to one of the
analyzed peptides was associated with achieving a sustained virological response.
GLIAL PROGENITOR CELL TRANSPLANTATION ENHANCES RECOVERY OF SENSORIMOTOR DEFICITS IN RATS AFTER TRAUMATIC BRAIN INJURY
Authors:   Research Institute of Molecular and Cellular Medicine, RUDN Medical Institute, Moscow, Sudina A.K. , Goldshtein D.V. , Silachev D.N. , Salikhova D.I. ,   Research Centre for Medical Genetics, Moscow,   Lomonosov Moscow State University
Published: February 2025

The search for new methods of therapy of traumatic brain injury is one of the important tasks of modern biomedicine. In this
work, the therapeutic effect of glial progenitor cells obtained from induced pluripotent stem cells was investigated in an experimental
model of traumatic brain injury.
COMPOSITE HYDROGEL MATRICES FOR IMMOBILIZATION OF MICROORGANISMS
Authors:   Udmurt State University, Izhevsk, Tarasova D.A. , Cherenkov I.A.
Published: February 2025

One of the classic methods of biotechnology is the immobilization of cells into hydrogels that mimic the natural conditions
for microorganisms. The aim of the work is to develop a technology for the production of multicomponent hydrogel carriers based on
biocompatible polymers (PVA and lignin) for the immobilization of microorganisms that recycle organic waste.
ARAMETERS OF MICROBIAL FUEL CELL USING MODIFIED ANODE BASED ON GRAPHENE OXIDE
Authors:   Laboratory of Ecological and Medical Biotechnology, SRC “BioChemTech” Tula State University, Fedina V.V. , Kovaleva A.A. , Alferov S.V.
Published: February 2025

Biofuel cells are an actively developing technology that involves the use of living systems to generate electricity. In this work,
membrane fractions of Gluconobacter oxydans bacteria were applied on electrodes modified with graphene oxide. The modification of
graphite felt leads to an increase in its electrochemical properties, due to which the process of electron transfer between the electrode
and the biocatalyst is increased.
INVERTED TERMINAL REPEATS OF THE ADENO-ASSOCIATED VIRUS DEMONSTRATE PROMOTER ACTIVITY IN GABAERGIC NEURONS IN VITRO
Authors:   Institute of Gene Biology RAS, Moscow, Lunev E.A. ,   Marlin Biotech, LLC, Sochi,   Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Moscow,   Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine, FMBA of Russia, Moscow,   Endocrinology Research Center, Moscow, Volovikov E.A. , Popov S.V. , Egorova T.V. , Bardina M.V.
Published: February 2025

We detected the ITR promoter activity of the AAV2 in transduced iPSCs-derived GABAergic neurons by RNAseq analysis.
PERSPECTIVES OF AI METHODS IN DECREASING DEATHS RATE OF THE RUSSIAN WORKING POPULATION FROM CARDIOVASCULAR DISEASES
Authors:   Рeoples’ Friendship University of Russia named after P. Lumumba, Moscow, Rusina D.S. ,   Institute of Laboratory Medicine, Moscow,   RTK-element, LLC, Moscow, Varekha N.V. , Gimadiev R.R. , Schegolev O.B. , Varakina-Mitrail K.A. , Dimitrov V.O.
Published: February 2025

According to Rosstat, cardiovascular disease (CVD) remains the leading cause of mortality in the Russian Federation, particularly among men of productive age, who exhibit significantly higher mortality rates compared to women. This discrepancy may be
partially attributed to the protective effects of female sex hormones. Meanwhile, preventive healthcare practices in Russia are underdeveloped, as evidenced by only 35.3 % of citizens participating in annual health checkups. This paper argues that leveraging artificial
intelligence (AI) to predict lipid profile values can identify high-risk populations and ultimately reduce cardiovascular mortality.
DELIVERY OF TETRAMERIZED SINGLE-DOMAIN ANTIBODY GENES USING A RECOMBINANT ADENO-ASSOCIATED VIRAL VECTOR TO INDUCE PROTECTION AGAINST INFLUENZA A VIRUS AND SARS-COV-2 VIRUS
Authors:   Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Ryabova E.I. ,   Moscow State Academy of Veterinary Medicine and Biotechnology — MVA by K.I. Skryabin,   Lomonosov Institute of Fine Chemical Technologies, Moscow, Derkaev A.A. , Dovgiy M.A. , Voronina D.V. , Blinov A.A. , Vansovich A.S. , Khosain R.M. , Favorskaya I.A. , Shcheblyakov D.V. , Esmagambetov I.B.
Published: February 2025

Influenza A and SARS-CoV-2 viruses continue to pose a serious threat to public health. In our study we obtained a recombinant
adeno-associated viral vector expressing the gene of tetramerized single-domain antibodies specific to various variants of the SARSCoV-2 virus and influenza A viruses. It was shown that a single intramuscular administration of the obtained vector provides protection
against influenza A infection and COVID-19 in a prophylactic mode.
Sports Psychology: Exploring the Origins, Development, and Increasing Demands in Sports and Exercise Sciences
Authors: Singh Vikas , Rajpurohit Ravindra Singh , Das Rajdeep , Bhutia Tenzing Norzom , Bisht Pawan
Published: February 2025

Today, psychology is widely recognised as a crucial element of gaining an advantage in sports. Sports psychology now offers a considerable competitive advantage. Furthermore, it offers insights into how to effectively function in aspects of our lives outside of athletics while nevertheless being vital for elite athletes to sustain high performance. the outcome Sport psychology aims to comprehend people’s behaviour, mental processes, and welfare in sports environments while embracing psychological theory and practises. The responsibilities of sports psychologists and new advancements in psychology in the field of sports and exercise sciences remain the primary issues of current expert discussions, despite the reality that sports psychology has recently been the subject of productive study and practical application. The goals of the study were met by the researcher in the current article through examination of articles published in specialised scientific journals, as well as research into official documents and informational sources from professional associations of sports psychologists. Physical and psychological qualities are both important for sports performance. The essay offers a theoretical examination of the tactical and conceptual advancements made in the psychology of sports and exercise around the world in order to look into the recent and prospective trends in this field.
Attitude ludique et sémiotique de l’identité : la tactilité cinétique dans les jeux vidéo
Authors: D’Armenio Enzo
Published: February 2025

Dans cet article, notre propos est d’analyser le rôle de la tactilité dans les jeux vidéo et sa contribution à la construction de leur dynamique de sens. Dans la première partie de l’article, nous discuterons du concept d’attitude ludique décrit par Jacques Henriot et Sébastien Genvo. Il ne s’agit pas d’une propriété ontologiquement afférente aux objets, bien que les jeux soient des objets prédisposés à encourager cette attitude : chanter avec une fourchette pendant un repas revient à la transformer par une pratique ludique en un simulacre d’objet de chant et donc à encourager d’autres individus à reconnaître et à adopter la même attitude. À la lumière de la sémiotique des pratiques, nous définirons l’attitude ludique comme l’inflexion particulière d’une pratique sémiotique qui, en convoquant des modèles de schématisation et d’accommodation d’une autre situation sémiotique, dédouble les rôles identitaires tout en maintenant active la transduction co-structurante entre ces deux situations. Cela nous permettra, d’une part, de distinguer cette attitude du régime de croyance de la fiction et, d’autre part, de mettre en évidence le travail identitaire au cœur de toute sémiose. Dans la deuxième partie de l’article, nous tenterons d’analyser la tactilité particulière déployée par les jeux vidéo. À partir des champs sensibles identifiés dans le cadre de la sémiotique du corps — en particulier la sensori-motricité, le champ des mouvements intimes intransitifs et le champ transitif — nous examinerons la manière dont ces champs contribuent à la syntaxe figurale des jeux vidéo. Notre thèse est que les jeux vidéo imposent des restrictions considérables au champ plus large des pratiques ludiques et configurent une tactilité cinétique particulière : l’accès aux expériences de jeux vidéo implique la réalisation de mouvements sur une interface et la transformation de ces mouvements en mouvements dans les mondes numériques. La discussion de l’articulation et des limites de cette tactilité nous permettra d’examiner comment l’attitude ludique est réalisée dans les jeux vidéo à travers une corrélation constitutive entre mécanismes d’immersion cinétique et mécanismes d’interprétation réflexive.
Matière, plasmaticité et modes du sensible. La praxis énonciative de l’animation stop-motion et son application aux jeux vidéo
Authors: Conde Juan Alberto
Published: February 2025

Cet article propose d’aborder la « tactilité du visuel » à travers la technique d’animation en stop-motion et la manière particulière dont cette technique fait usage de la photographie, mais aussi d’objets et de matériaux modelés. Pour ce faire, on examine l’approche sémiotique de l’image photographique sous l’angle de la corporéité et des modes du sensible associés à la praxis énonciative (Dondero, Fontanille), ainsi que la manière singulière dont l’animation en stop-motion engage d’autres dimensions de la corporalité dans sa production et sa réception. Cette singularité est liée à ce que Cyril Lepot appelle la plasmaticité, un trait spécifique de l’animation qui réside dans sa capacité à représenter des matières, des textures et des objets à partir de matérialités différentes. Après avoir établi ce champ de la praxis énonciative du stop-motion, l’article examine l’usage de cette technique dans la conception de jeux vidéo tels que Feltopia ou The Neverhood (et ses suites), en avançant quelques hypothèses sur les possibilités de sens que la remédiation (Bolter et Grusin) de cette technique offre au domaine du design vidéoludique, notamment en ce qui concerne la possibilité d’offrir aux spectateurs une expérience de la « tactilité du visuel ».
THE EFFECT OF INTELLECTUAL CAPITAL ON FIRM VALUE WITH CORPORATE GOVERNANCE AS A MODERATING VARIABLE
Authors: Darmiani  , Muliati  , Ansar Muhammad
Published: February 2025

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh ukuran perusahaan, manajemen risiko perusahaan, dan modal intelektual terhadap nilai perusahaan dengan tata kelola perusahaan yang baik sebagai variabel moderasi dengan menggunakan sampel perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia tahun 2017-2021. Metode analisis data yang digunakan adalah Partial Least Squares dengan software WarpPLS 7.0. Hasil penelitian menunjukkan bahwa terdapat pengaruh signifikan dan positif secara parsial ukuran perusahaan berpengaruh positif signifikan terhadap nilai perusahaan, namun manajemen risiko perusahaan dan modal intelektual menunjukkan pengaruh parsial signifikan dan negatif terhadap nilai perusahaan. Mengenai efek moderasi, sebagian besar temuan menunjukkan bahwa GCG tidak memoderasi hubungan antara manajemen risiko perusahaan dan modal intelektual terhadap nilai perusahaan.
A set of Quantum–Mechanically Derived Force Fields for Natural and Synthetic Retinal Photoswitches
Authors: Daoud Razan , Veglianti Simone , Piras Anna , Semmeq Abderrahmane , Giannini Samuele , Prampolini Giacomo , Padula Daniele
Published: February 2025

The diverse biological functions of rhodopsins are all triggered by photoexcitation of retinal protonated Schiff base chromophores. This diversity can be traced back not only to variations in the protein scaffolds in which the chromophore is embedded, but also to the different isomeric forms of the chromophore itself, whose role is crucial in several processes. Although most computational approaches for these systems often require classical molecular dynamics, efforts in providing a set of parameters able to accurately and consistently model through molecular mechanics several isomeric chromophores are lacking in literature. The most recent efforts entail either refinements of general purpose force fields, which lack in accuracy, or parameterisation strategies that include environmental effects, making the resulting parameters not transferable to a different embedding. In this work, we provide accurate intramolecular force fields based on data purposely computed using Møller–Plesset second order perturbation theory, specifically tailored for varied natural retinal Protonated Schiff Bases and synthetic analogues often employed in retinal-based photoswitches. We demonstrate the quality of our quantum–mechanically derived force fields (QMD–FFs) through a wide set of validation tests. These consistently indicate an excellent description of each chromophore in terms of equilibrium geometries, conformational landscapes, and optical properties in comparison to literature data, experimental measurements, and reference QM calculations. Our intramolecular QMD–FFs, distributed in electronic format, can be adopted to describe these chromophores in complex environments, exploiting in- termolecular parameters compatible with the ones available in literature for biological macromolecules.
Lanthanide Selective Biomimetic Nanopores
Authors: Behera Harekrushna , Duncan Tyler , Samineni Laxmicharan , Oh Hyeonji , Jogdand Ankit , Karnik Arnav , Dhiman Raman , Fica Aida , Hsieh Tzu-Yun , Ganesan Venkat , Kumar Manish
Published: February 2025

Lanthanides serve as essential elements for modern technology, playing critical roles in batteries, wind turbines, portable electronics, and energy efficient lighting. However, purifying lanthanides from ores and recycling them from end-of-life consumer materials is costly and damaging to the environment due to inefficient separation technologies. Lanthanide-lanthanide ion separations are challenging due to similarity in their hydrated size, with commonly used methods limited to single stage selectivities of ~ 2-3. Here we present supramolecular membrane channel nanopores based on a pillar[5]arene scaffold with appended diphenylphosphine oxide (DPP) ligands that show high transport selectivity (~18:1) of the medium lanthanide, Europium (Eu3+), over all measured monovalent and divalent ions, including protons. These membrane channels also have high lanthanide-lanthanide transport selectivity with Eu3+/La3+ selectivity of >40 and Eu3+/Yb3+ selectivity of ~30. Molecular dynamics simulations indicate that the high selectivity observed is due to specific water-mediated interactions between the hydrated ions and the channel. Our findings could offer a promising avenue for efficient lanthanide separations, marking an important advancement towards a greener and more sustainable future.
Photo-induced Metal-to-Metal Electron Transfer in a Cyanido bridged [FeCo] Chain: Role of Bridging Cyanide and Solvent
Authors: Mehta Sakshi , Kamilya Sujit , Ghosh Subrata , Dechambenoit Pierre , Rouzières Mathieu , Mathonière Corine , Clérac Rodolphe , Mondal Abhishake
Published: February 2025

We report two cyanido-bridged [FeCo] chains, {[FeIII(Tp)(CN)3][CoII(vim)4](BF4)•H2O•CH3CN} (1), {[FeIII(Tp)(CN)3][CoII(vim)4](BF4)•CH3CN} (2), (Tp: trispyrazolylhydroborate, vim: 1-Vinylimidazole) containing diamagnetic [FeIILS(S=0)-CoIIILS(S=0)] units in 2-300 K range. 1 undergoes photo-induced metal-to-metal-electron-transfer under light irradiation at low temperature with thermal relaxation around 80 K, whereas 2 is photo inactive.
White-bellied Pangolin (Phataginus tricuspis) Nest Box Activity Budgets And Behavior Milestones
Authors: Lauderdale Lisa K. , Wojciechowski Sheila , Miller Lance J.
Published: February 2025

White-bellied pangolins (Phataginus tricuspis) are semi-arboreal mammals from equatorial Africa. Listed as endangered by the IUCN, their population is under severe threat due to illegal hunting for their meat and scales. Many aspects of pangolin behavior, particularly maternal and early pup behavior, remain largely undocumented. Gathering behavioral data for both the dam and pup allows for the development of baseline rates of maternal and pup behavior as well as the setting of early behavioral milestones. This study defined and quantified early maternal and pup behavioral trends inside the nesting box for zoo-housed, white-bellied pangolins. Data were collected from August 2018 to January 2022. Videos were recorded for 24-hours every fourth day (e.g., Day 1, Day 4, Day 8, etc.) for the first 30 days of life. The behaviors of six dam-pup pairs (four male pups and two female pups) were scored to develop activity budgets, describe maternal behaviors, and define early behavioral milestones. Wilcoxon signed-rank tests were used to compare nocturnal and diurnal hours. Pairs spent the majority of their time curled in a ball together and were more active at night than during the day. Dams spent the majority of their time in contact with the pup with occasional separations as early as the first day of life. Pups were born precocial and engaged in digging and nosing under the dam’s scales as early as the first day of life. These behavioral observations and milestones can be used as a baseline when monitoring future dam-pup pairs, to enhance husbandry protocols, and to assess the welfare of both dams and pups.
The Moral Harms of Homelessness
Authors: Hillier-Smith Bradley
Published: February 2025

It is well-established that those facing homelessness suffer severe harms and deprivations. Homeless persons are among the worst-off people in any given society. And yet homelessness is a relatively undertheorized issue in ethics and social and political philosophy, and it remains an enduring feature of many affluent, liberal democratic societies. This paper aims to provide an account of the underacknowledged moral harms of homelessness that can ground and motivate adequate durable solutions and public policy reform to alleviate homelessness. The paper argues that the few existing philosophical accounts of the moral harms of homelessness—the freedom-based, privacy-based and care-based accounts—reveal important insights but suffer limitations. The paper then advances a novel status-based account that foregrounds the social and moral status poverty of homeless persons. This account reveals an underacknowledged but fundamental moral harm of homelessness, addresses the limitations of existing accounts, and grounds adequate durable solutions. This more complete account can then help challenge the unsettling tacit acceptance of homelessness in contemporary societies and provide a normative framework for urgent reform.