bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential of Nuclear Imaging Techniques to Study the Oral Delivery of Peptides
Authors: Saxena Tanya , Sie Claire , Lin Kristine , Ye Daisy , Saatchi Katayoun , Häfeli Urs O.
Published: December 2022

Peptides are small biomolecules known to stimulate or inhibit important functions in the human body. The clinical use of peptides by oral delivery, however, is very limited due to their sensitive structure and physiological barriers present in the gastrointestinal tract. These barriers can be overcome with chemical and mechanical approaches protease inhibitors, permeation enhancers, and polymeric encapsulation. Studying the success of these approaches pre-clinically with imaging techniques such as fluorescence imaging (IVIS) and optical microscopy is difficult due to the lack of in-depth penetration. In comparison, nuclear imaging provides a better platform to observe the gastrointestinal transit and quantitative distribution of radiolabeled peptides. This review provides a brief background on the oral delivery of peptides and states examples from the literature on how nuclear imaging can help to observe and analyze the gastrointestinal transit of oral peptides. The review connects the fields of peptide delivery and nuclear medicine in an interdisciplinary way to potentially overcome the challenges faced during the study of oral peptide formulations.
Cupriavidus necator-Produced Polyhydroxybutyrate/Eudragit FS Hybrid Nanoparticles Mitigates Ulcerative Colitis via Colon-Targeted Delivery of Cyclosporine A
Authors: Lee Juho , Saparbayeva Aruzhan , Hlaing Shwe Phyu , Kwak Dongmin , Kim Hyunwoo , Kim Jihyun , Lee Eun Hee , Yoo Jin-Wook
Published: December 2022

Polyhydroxybutyrate (PHB) has emerged as a novel material for replacing various plastics used in the medical field. However, its application as a drug-delivery carrier for colitis-targeted delivery has not been explored. In this study, we used biosynthesized PHB combined with Eudragit FS (EFS) and cyclosporine A (CSA) to develop pH-responsive controlled CSA-releasing nanoparticles (CSA-PENPs) for colitis-targeted drug delivery and demonstrated its enhanced therapeutic efficacy in a dextran sulfate sodium (DSS)-induced murine colitis model. PHB was successfully biosynthesized in the bacterium Cupriavidus necator, as demonstrated by 1H-NMR and FT-IR analyses. CSA-PENPs were fabricated via the oil-in-water emulsion solvent evaporation method. Owing to the potent pH-responsive and sustained drug release properties provided by PHB and EFS, CSA-PENPs could deliver a sufficient amount of CSA to inflamed tissues in the distal colon; in contrast, CSA-loaded EFS nanoparticles displayed premature burst release before reaching the target site. Due to enhanced CSA delivery to colitis tissues, CSA-PENPs exhibited potent anti-inflammatory effects in the DSS-induced murine colitis model. Overall, CSA-PENPs could be a promising drug-delivery system for treating ulcerative colitis.
Recent Advancements in Drug Delivery of Sinomenine, A Disease-Modifying Anti-Rheumatic Drug
Authors: Chen Xin , Lu Chengcheng , Duan Yanwen , Huang Yong
Published: December 2022

Sinomenine (SIN) is a benzyltetrahydroisoquinoline-type alkaloid isolated from the dried plant root and stem of Sinomenium acutum (Thumb.) Rehd.et Wils, which shows potent anti-inflammatory and analgesic effects. As a transforming disease-modifying anti-rheumatic drug, SIN has been used to treat rheumatoid arthritis over twenty-five years in China. In recent years, SIN is also in development for use against other disorders, including colitis, pain, traumatic brain injury, and uveitis. However, its commercial hydrochloride (SIN-HCl) shows low oral bioavailability and certain allergic reactions in patients, due to the release of histamine. Therefore, a large number of pharmaceutical strategies have been explored to address these liabilities, such as prolonging release behaviors, enhancing skin permeation and adsorption for transdermal delivery, targeted SIN delivery using new material or conjugates, and co-amorphous technology. This review discusses these different delivery strategies and approaches employed to overcome the limitations of SIN for its efficient delivery, in order to achieve improved bioavailability and reduced side effects. The potential advantages and limitations of SIN delivery strategies are elaborated along with discussions of potential future SIN drug development strategies.
Blockade of Cholecystokinin Type 2 Receptors Prevents the Onset of Vincristine-Induced Neuropathy in Mice
Authors: Bernard Amandine , Danigo Aurore , Mroué Mohamad , Rovini Amandine , Richard Laurence , Nizou Angélique , Desmoulière Alexis , Sturtz Franck , Demiot Claire , Bourthoumieu Sylvie
Published: December 2022

Vincristine (VCR) is responsible for the onset of the VCR-induced peripheral neuropathy (VIPN), associated with neuropathic pain. Several reports have strongly linked the cholecystokinin type 2 receptor (CCK2R) to nociceptive modulation. Thus, our aim was to evaluate the effect of CCK2R blockade on the onset of VIPN, as well as its interaction on VCR anticancer efficacy. VCR was administrated in mice for 8 days (100 µg/kg/d, i.p.). Transcriptomic analysis of the dorsal root ganglia (DRG) was performed at day 7 in VCR and control mice. Proglumide (30 mg/kg/d), a CCK1R and CCK2R antagonist, and Ly225910 (1 mg/kg/d), a selective CCK2R antagonist, were administrated one day before and during VCR treatment. Tactile sensitivity was assessed during treatments. Immunofluorescence and morphological analyses were performed on the skin, DRG and sciatic nerve at day 7. The cytotoxicity of VCR in combination with proglumide/Ly225910 was evaluated in human cancer cell lines. Cck2r was highly upregulated in the DRG of VCR mice. Proglumide accelerated the recovery of normal sensitivity, while Ly225910 totally prevented the onset of allodynia and nerve injuries induced by VCR. Proglumide or Ly225910 in combination with VCR did not affect the cytotoxicity of VCR. Targeting CCK2R could therefore be an effective strategy to prevent the onset of VIPN.
Unveiling the Role of the Beam Shape in Photothermal Beam Deflection Measurements: A 1D and 2D Complex Geometrical Optics Model Approach
Authors: Swapna Mohanachandran Nair Sindhu , Korte Dorota , Sankararaman Sankaranarayana Iyer
Published: December 2022

The preponderance of laser beam shapes cannot be ruled out during the implementation of an optical experiment nor during the formulation of its theoretical background. The present work elucidates the role of Gaussian and top-hat beam shapes in generating and analysing the photothermal beam deflection (PBD) signals. The complex geometrical optics models encompassing the perturbations in the phase and amplitude of the probe beam with one-dimensional (1D) and two-dimensional (2D) approaches is employed to curve fit the PBD signal and are compared. From the fitted curve, the thermal diffusivity and conductivity of the sample are calculated with the 1D and 2D models. A uniform intensity distribution over the sample, like a top-hat beam, is achieved using an optical lens system and verified using a beam profiler. When the phase and amplitude of the PBD signal are fitted at different positions of the lens, i.e., in focussed and defocussed conditions, it is observed that difference in the measured thermal characteristics is about 30% for the Gaussian pump beam profile, whereas it is only <4% for top-hat beam. Even though the fitting accuracy and sum of residues estimated for the 2D model are better than 1D, the ease of computation with the 1D model employing top-hat excitation suggests the application of the top-hat profile in photothermal experiments.
Low Light Facilitates Cyclic Electron Flows around PSI to Assist PSII against High Temperature Stress
Authors: Sun Yongjiang , Wang Qi , Xiao Huijie , Cheng Jin
Published: December 2022

Photosystem II (PSII) of grapevine leaves is easily damaged under heat stress, but no such injury is observed when the leaves are heated in low light. To elucidate the mechanisms, we compared the photosynthetic characteristics of grapevine seedlings under heat treatments (42 °C) for 4 h in the dark or low light (200 μmol m−2 s−1). At 42 °C in the dark, the PSII maximum quantum yield (Fv/Fm) decreased significantly with the increase in time but did not change much in low light. The JIP (chlorophyll a fluorescence rise kinetics) test results showed that low light significantly alleviated the damage to the oxygen evolving complexes (OECs; the K-step was less visible) by heat stress. Further, in the presence of de novo D1 protein synthesis inhibitor chloramphenicol, Fv/Fm did not differ significantly between dark and light treatments under heat stress. The 50% re-reduction (RR50) of P700+ on cessation of far-red illumination was faster after light treatment than that in the dark. After exposure to 25 °C in a low light for 15 min, Y(NO) (the constitutive non-regulatory non-photochemical quenching) treated by heat stress and darkness was higher than that by heat stress and light. Overall, our results suggested that enhanced CEFs around PSI in low light could assist PSII against heat damage by maintaining the rate of PSII repair and inhibiting the non-radiative charge recombination in PSII reaction centers.
Identification and Quantification of Polyphenols in Croatian Traditional Apple Varieties
Authors: Skoko Ana-Marija Gotal , Šarkanj Bojan , Lores Marta , Celeiro Maria , Babojelić Martina Skendrović , Kamenjak Dragutin , Flanjak Ivana , Jozinović Antun , Kovač Tihomir , Lončarić Ante
Published: December 2022

Apples and apple-based products are particularly interesting due to being a good source of polyphenols in an everyday diet. Recently there has been increased interest in the preservation of traditional apple varieties due to studies that suggest that traditional apple varieties have a higher content of polyphenols and antioxidant activity compared to commercial varieties. This study shows that traditional apple varieties contain higher concentration of polyphenolic compounds than conventional ones, such as chlorogenic acid (1.29–456 mg/kg dw), catechin (0.70–312 mg/kg dw), epicatechin (1.75–244 mg/kg dw), procyanidin B1 + B2 (4.08–358 mg/kg dw) and quercetin-3-glucoside (0.96–231 mg/kg dw). This research underlies the great potential of traditional apple varieties as a source of natural antioxidants and polyphenolics.
Endocarp Development Study in Full Irrigated Olive Orchards and Impact on Fruit Features at Harvest
Authors: Sánchez-Piñero Marta , Martín-Palomo María José , Moriana Alfonso , Corell Mireia , Pérez-López David
Published: December 2022

Endocarp development in olive trees includes three periods: growth (Period I), massive sclerification (Period II) and maximum hardening (Period III). The two first are strongly related to yield and irrigation management. Period I was reported to coincide with mesocarp cell division and thus with final fruit size. Period II was considered to be the most drought-resistant phenological stage. However, little is known in olive trees about the length of these periods and their capacity for predicting fruit size at harvest. The aim of this work was to evaluate the length of both periods in different cultivars and different location of full irrigated orchards. We also aimed to study the fruit feature impact on harvest at the end of Period I. Data from full irrigated olive orchards of cv Cornicabra, Arbequina and Manzanilla in two different locations (Ciudad Real, Central Spain, and Seville, South Spain) were used. The pattern of pit-breaking pressure throughout the season was measured with fruit samples for several years (2006 to 2022). These data and climatic data were used to compare different estimation methods for the length of Period I and II of endocarp development. Then, fruit volume and dry weight at the end of Period I were used to estimate fruit features at harvest. Results suggest that the Period I length was less temperature- and cultivar-dependent than expected. The duration of this period was almost constant at around 49 days after full bloom. Thermal time was negatively correlated with fruit size at the end of Period I. On the contrary, a lineal thermal model presented the lowest variability when estimating the Period II length, which was also affected by the cultivar. The best fit between fruit dry weight and volume at Period I vs. harvest was unique for oil cultivars (Cornicabra and Arbequina), while cv Manzanilla presented a different relationship. A temperature increase in the future would not affect the Period I length but would reduce the fruit size at the end of this period and at harvest.
Temperate Lianas Have More Acquisitive Strategies than Host Trees in Leaf and Stem Traits, but Not Root Traits
Authors: Zhou Zhe , Chen Binzhou , Zhao Hongru , Yi Junjie , Liu Shiqiang , Tie Dan , Xu Jinshi , Hu Shu , Guo Yaoxin , Yue Ming
Published: December 2022

Increasingly, tropical studies based on aboveground traits have suggested that lianas have a more acquisitive strategy than trees, thereby possibly explaining the increase in lianas relative to trees in many tropical forests under global change. However, few studies have tested whether this pattern can be extended to root traits and temperate forests. In this study, we sampled 61 temperate liana-host tree pairs and quantified 11 commonly studied functional traits representative of plant economics in roots, stems, and leaves; we aimed to determine whether root, stem and leaf traits are coordinated across lifeforms, and whether temperate lianas are also characterized by more fast and acquisitive traits than trees. Our results showed that leaf and stem traits were coordinated across lifeforms but not with root traits, suggesting that aboveground plant economics is not always correlated with belowground economics, and leaf and stem economic spectra cannot be expanded to the root directly. Compared with host trees, lianas had more acquisitive leaf and stem traits, such as higher specific leaf area and lower leaf dry matter content, leaf carbon content, leaf mass per area, and wood density, suggesting that lianas have a more acquisitive strategy than host trees in the temperate forest. The differences between lianas and trees in plant strategy may drive their contrasting responses to the changing temperate forest environment under global change.
Chemical Survey of Three Species of the Genus Rauhia Traub (Amaryllidaceae)
Authors: Tallini Luciana R. , Osorio Edison H. , Berkov Strahil , Torras-Claveria Laura , Rodríguez-Escobar María L. , Viladomat Francesc , Meerow Alan W. , Bastida Jaume
Published: December 2022

Plant biodiversity is an important source of compounds with medicinal properties. The alkaloid galanthamine, first isolated from Galanthus woronowii (Amaryllidaceae), is approved by the FDA for the palliative treatment of mild to moderate Alzheimer’s disease due to its acetylcholinesterase (AChE) inhibitory activity. Obtaining this active pharmaceutical ingredient, still sourced on an industrial scale from the Amaryllidaceae species, is a challenge for pharmaceutical companies due to its low natural yield and the high cost of its synthesis. The aim of this work was to determine the alkaloid profile of three different Rauhia (Amaryllidaceae) species collected in Peru, and to assess the potential application of their extracts for the treatment of Alzheimer’s disease. The alkaloids were identified by gas chromatography coupled to mass spectrometry (GC-MS), and the AChE inhibitory activity of the extracts was analyzed. Thirty compounds were quantified from the Rauhia species, the R. multiflora extract being the most interesting due to its high diversity of galanthamine-type structures. The R. multiflora extract was also the most active against AChE, with the half maximal inhibitory concentration (IC50) values of 0.17 ± 0.02 μg·mL−1 in comparison with the IC50 values of 0.53 ± 0.12 μg·mL−1 for galanthamine, used as a reference. Computational experiments were carried out on the activity of the galanthamine-type alkaloids identified in R. multiflora toward five different human AChE structures. The simulation of the molecules 3-O-acetylgalanthamine, 3-O-acetylsanguinine, narwedine, and lycoraminone on the 4EY6 crystal structure theoretically showed a higher inhibition of hAChE and different interactions with the active site compared to galanthamine. In conclusion, the results of this first alkaloid profiling of the Rauhia species indicate that R. multiflora is an important natural source of galanthamine-type structures and could be used as a model for the development of biotechnological tools necessary to advance the sustainable production of galanthamine.
High Input of Nitrogen Fertilization and Short Irrigation Frequencies Forcefully Promote the Development of Verticillium Wilt of Olive
Authors: Pérez-Rodríguez Mario , Santos-Rufo Antonio , López-Escudero Francisco Javier
Published: December 2022

It is known that high N doses, N/K imbalances, and frequent irrigation favor Verticillium wilt. The influence of fertilization and its interaction with the frequency of irrigation on the development of Verticillium wilt of olive (VWO) has been evaluated. A split-split-plot design in microplots with two naturally infested soils of different texture was established for studying three fertilization treatments (NO3Ca, NPK and without fertilization), plus two irrigation frequencies (daily and deficit). The treatments were applied by means of fertigation, evaluating the susceptible cultivar Picual. Final disease incidence in plants subjected to NO3Ca daily treatment was 100% regardless of soil texture. However, final mortality in these plants was 37% and 85.2% in clay and sandy loam soils, respectively. In addition, the area under the disease progress curve values were significantly higher (49.1%) in plants subjected to NO3Ca fertilization compared to those not fertilized or fertilized with N-P-K when plants were grown in clay soil. This value in the sandy loam soil was significantly higher in the NO3Ca daily irrigation treatment (94.3%), followed by the N-P-K-daily treatment (61.1%) which also was significantly higher than the unfertilized daily, N-deficit and NPK-deficit treatments (37.8, 42.6 and 44.9%, respectively). The plants submitted to unfertilized-deficit treatment reached the lowest value (9.6%). In this work it can be concluded that the application of fertilizer or the application of fertilizer with daily irrigation in naturally infested soils increases the development of VWO in Picual.
Experimental Investigation of Electro-Mechanical Behavior of Silver-Coated Teflon Fabric-Reinforced Nafion Ionic Polymer Metal Composite with Carbon Nanotubes and Graphene Nanoparticles
Authors: Yesaswi Ch Sridhar , Sahu Santosh Kumar , Sreekanth P S Rama
Published: December 2022

Ionic Polymer Metal Composites (IPMCs) are in high demand owing to the ongoing advancements in technology for various applications. New fabrication techniques and a quick retort towards the applied load are the significant reasons for considering IPMCs in smart devices. Here, a Teflon fabric-reinforced Nafion (TFRN) membrane is used to create an IPMC. The materials employed as electrodes are silver and nanofillers. The basement membrane, Nafion 438 (N-438), is sandwiched between the electrodes using a chemical decomposition technique. Subsequently, the electromechanical properties (actuation) of the membrane are tested. The micro and molecular structure of the IPMC membrane coated with Silver (Ag), Ag-Carbon nanotubes (CNTs), and Ag-Graphene nanoparticles samples are examined with the help of SEM and X-ray diffraction (XRD). The membrane scratch test is carried out to evaluate the abrasion and wear resistance of the membrane. The lowest coefficient of friction is shown by N438 + Ag + Graphene (0.05), which increased by 300% when compared to a pure N438 membrane. The hydration and tip deflection test were also performed to understand the water uptake percentage. At 90 °C, the highest water uptake was observed for N438 + Ag + Graphene (0.05), which decreased by 60, 42, 23, 14 and 26% when compared to N438, N438 + Ag, N438 + Ag + CNT (0.01), N438 + Ag + CNT (0.05) and N438 + Ag + Graphene (0.01), respectively. A proportional relationship between hydration level and tip deflection is observed and the highest bending performance is observed for the N438 + Ag + Graphene (0.05) membrane.
Multiscale Characterization at Early Ages of Ultra-High Performance Geopolymer Concrete
Authors: Abdellatief Mohamed , Alanazi Hani , Radwan Mohammed K. H. , Tahwia Ahmed M.
Published: December 2022

The main obstacle of using geopolymer as a construction repair material is its slow strength development rate, which is the most significant attribute of an early-age opening for traffic and striking-off formwork. Geopolymer technology has recently attracted huge interest as an alternative to traditional cementitious materials with low environmental impact. Thus, this study investigates the feasibility of developing an ultra-high performance geopolymer concrete (UHPGC) with the aim of achieving high early-age strength. For this purpose, UHPGC mixtures activated with different potassium hydroxide molarities and aluminosilicate material types were developed and examined being cured with different curing temperatures. The early strength and durability of the UHPGC after 8 and 24 h were investigated. Experimental results revealed that the optimal mix design of UHPGC corresponds to a KOH molarity of 16 M and a 30% silica fume content. Furthermore, former mixture cured at 100 °C gave superior 8 and 24 h early strength values of 79 and 134 MPa, respectively. Moreover, a superior interaction of slag, silica fume, and activator solution at early age for UHPGC is revealed by the microstructural characteristics examined by a field emission scanning electron microscope (FESEM) with energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy analysis, and thermogravimetric (TGA) techniques. It was also found that the compressive strength results and the results of the microstructure analysis are well coincided. The experimental results obtained in this study emphasize the feasibility of using developed UHPGC as an eco-friendly quick repair materials The development of one-part UHPGC as a quick, cost-effective, and high-strength product for all construction repair maintenance will lead to huge improvements in the structural capacity and durability of structural components.
Optimizing Polymer Costs and Efficiency in Alkali–Polymer Oilfield Applications
Authors: Hincapie Rafael E. , Borovina Ante , Clemens Torsten , Hoffmann Eugen , Tahir Muhammad , Nurmi Leena , Hanski Sirkku , Wegner Jonas , Janczak Alyssia
Published: December 2022

In this work, we present various evaluations that are key prior field applications. The workflow combines laboratory approaches to optimize the usage of polymers in combination with alkali to improve project economics. We show that the performance of AP floods can be optimized by making use of lower polymer viscosities during injection but increasing polymer viscosities in the reservoir owing to “aging” of the polymers at high pH. Furthermore, AP conditions enable the reduction of polymer retention in the reservoir, decreasing the utility factors (kg polymers injected/incremental bbl. produced). We used aged polymer solutions to mimic the conditions deep in the reservoir and compared the displacement efficiencies and the polymer adsorption of non-aged and aged polymer solutions. The aging experiments showed that polymer hydrolysis increases at high pH, leading to 60% higher viscosity in AP conditions. Micromodel experiments in two-layer chips depicted insights into the displacement, with reproducible recoveries of 80% in the high-permeability zone and 15% in the low-permeability zone. The adsorption for real rock using 8 TH RSB brine was measured to be approximately half of that in the case of Berea: 27 µg/g vs. 48 µg/g, respectively. The IFT values obtained for the AP lead to very low values, reaching 0.006 mN/m, while for the alkali, they reach only 0.44 mN/m. The two-phase experiments confirmed that lower-concentration polymer solutions aged in alkali show the same displacement efficiency as non-aged polymers with higher concentrations. Reducing the polymer concentration leads to a decrease in EqUF by 40%. If alkali–polymer is injected immediately without a prior polymer slug, then the economics are improved by 37% compared with the polymer case. Hence, significant cost savings can be realized capitalizing on the fast aging in the reservoir. Due to the low polymer retention in AP floods, fewer polymers are consumed than in conventional polymer floods, significantly decreasing the utility factor.
Wood Flour Modified by Poly(furfuryl alcohol) as a Filler in Rigid Polyurethane Foams: Effect on Water Uptake
Authors: Acosta Andrey , Aramburu Arthur B. , Beltrame Rafael , Gatto Darci A. , Amico Sandro , Labidi Jalel , Delucis Rafael de Avila
Published: December 2022

The use of lignocellulosic fillers in rigid polyurethane foams (RPUFs) has been receiving great attention due to their good mechanical and insulation properties and the high sustainable appeal of the obtained cellular polymers, although high water uptakes are found in most of these systems. To mitigate this detrimental effect, RPUFs filled with wood flour (2.5% wt) were fabricated with the addition of furfuryl alcohol (FA) to create a polymer grafted with the wood filler. Two concentrations of FA (10 wt% and 15 wt%) were investigated in relation to the wood flour, and the RPUFs were characterized for cell morphology, density, compressive properties, thermal stability, and water uptake. The introduction of wood flour as a filler decreased the cell size and increased the anisotropy index of the RPUFs and, in addition to that, the FA grafting increased these effects even more. In general, there were no significant changes in both mechanical and thermal properties ascribed to the incorporation of the fillers. On the other hand, a reduction of up to 200% in water uptake was ascribed to the FA-treated fillers.
High Efficiency and High Voltage Conversion Ratio Bidirectional Isolated DC–DC Converter for Energy Storage Systems
Authors: Wu Yu-En , Chen Kuan-Chi
Published: December 2022

In this paper, a novel high-efficiency bidirectional isolated DC–DC converter that can be applied to an energy storage system for battery charging and discharging is proposed. By integrating a coupled inductor and switched-capacitor voltage doubler, the proposed converter can achieve isolation and bidirectional power flow. The proposed topology comprises five switches and a common core coupled inductor that uses only a set of complementary pulse-width-modulated signals to control and achieve high voltage gain without requiring high turn ratios or excessive duty cycles. Moreover, the proposed topology can recover the leakage inductance energy to improve the conversion efficiency. The main switches exhibit zero-voltage switching, which reduces the switching losses. A 500-W bidirectional converter is used to verify the feasibility of the proposed bidirectional converter through theoretical analysis and experiments. The experimental results indicate that the highest efficiency of the proposed converter in the step-up and step-down modes is 97.59% and 96.5%, respectively.
Assessment of Spatio-Temporal Empirical Forecasting Performance of Future Shoreline Positions
Authors: Islam Md Sariful , Crawford Thomas W.
Published: December 2022

Coasts and coastlines in many parts of the world are highly dynamic in nature, where large changes in the shoreline position can occur due to natural and anthropogenic influences. The prediction of future shoreline positions is of great importance in the better planning and management of coastal areas. With an aim to assess the different methods of prediction, this study investigates the performance of future shoreline position predictions by quantifying how prediction performance varies depending on the time depths of input historical shoreline data and the time horizons of predicted shorelines. Multi-temporal Landsat imagery, from 1988 to 2021, was used to quantify the rates of shoreline movement for different time period. Predictions using the simple extrapolation of the end point rate (EPR), linear regression rate (LRR), weighted linear regression rate (WLR), and the Kalman filter method were used to predict future shoreline positions. Root mean square error (RMSE) was used to assess prediction accuracies. For time depth, our results revealed that the higher the number of shorelines used in calculating and predicting shoreline change rates the better predictive performance was yielded. For the time horizon, prediction accuracies were substantially higher for the immediate future years (138 m/year) compared to the more distant future (152 m/year). Our results also demonstrated that the forecast performance varied temporally and spatially by time period and region. Though the study area is located in coastal Bangladesh, this study has the potential for forecasting applications to other deltas and vulnerable shorelines globally.
iRun: Horizontal and Vertical Shape of a Region-Based Graph Compression
Authors: Umair Muhammad , Lee Young-Koo
Published: December 2022

Graph data are pervasive worldwide, e.g., social networks, citation networks, and web graphs. A real-world graph can be huge and requires heavy computational and storage resources for processing. Various graph compression techniques have been presented to accelerate the processing time and utilize memory efficiently. SOTA approaches decompose a graph into fixed-size submatrices and compress it by applying the existing graph compression algorithm. This approach is promising if the input graph is dense. Otherwise, an optimal graph compression ratio cannot be achieved. Graphs such as those used by social networks exhibit a power-law distribution. Thus, applying compression to the fixed-size block of a matrix could lead to the empty cell processing of that matrix. In this paper, we solve the problem of ordered matrix compression on a deep level, dividing the block into sub-blocks to achieve the best compression ratio. We observe that the ordered matrix compression ratio could be improved by adopting variable-shape regions, considering both horizontal- and vertical-shaped regions. In our empirical evaluation, the proposed approach achieved a 93.8% compression ratio on average, compared with existing SOTA graph compression techniques.
Testing Thymol-Based DES for the Elimination of 11 Textile Dyes from Water
Authors: Villar Lorena , Martínez-Rico Óscar , Asla Andrés , Domínguez Ángeles , González Begoña
Published: December 2022

Textile industries release dangerous wastewater that contain dyes into the environment. Due to their toxic, carcinogenic and mutagenic nature, they must be removed before the discharge. Liquid–liquid extraction has proven to be an efficient method for the removal of these dyes. As extractants, deep eutectic solvents (DESs) have shown excellent results in recent years, as well as presenting several green properties. Therefore, four different hydrophobic DESs based on natural components were prepared thymol:decanoic acid (T:D (1:1)), thymol:DL-menthol (T:M (1:1)), thymol:DL-menthol (T:M (1:2)) and thymol:coumarin (T:C (2:1)) for the extraction of Malachite Green (MG), Brilliant Blue G (BBG), Acid Yellow 73 (AY73), Reactive Red 29 (RR29), Acid Blue 113 (AB113), Reactive Black 5 (RB5), Remazol Brilliant Blue (RBB), Direct Yellow 27 (DY27), Acid Blue 80 (AB80), Direct Blue 15 (DB15) and Acid Violet 43 (AV43) dyes from water. The operational parameters of the liquid–liquid extraction were selected in order to save time and materials, resulting in 30 min of stirring, 15 min of centrifugation and an aqueous:organic ratio of 5:1. In these conditions, the highest values of extraction obtained were 99% for MG, 89% for BBG and 94% for AY73. Based on these results, the influence of the aqueous:organic phase ratio and the number of necessary stages to achieve water decolorization was studied.
Comparative Characterization of Grain Protein Content and Composition by Chromatography-Based Separation Methods (SE-HPLC and RP-HPLC) of Ten Wheat Varieties Grown in Different Agro-Ecological Zones of Algeria
Authors: Hacini Nesrine , Djelloul Radia , Hadef Ahmed , Samson Marie-Françoise , Desclaux Dominique
Published: December 2022

To characterize and compare the protein quality of ten durum wheat genotypes grown under three cropping modalities in Algeria (subhumid in Algiers, subhumid-semiarid in Constantine, and semiarid in Sétif), the protein profile of their kernels was performed by High-Performance Liquid Chromatography (SE-HPLC and RP-HPLC). The “variety” factor has a major impact, mainly on the insoluble fraction (Fi), on the gliadin/glutenin ratio, on the large and small glutenin aggregates (F1 and F2, respectively), and on ω-gliadins and high molecular weight albumins (F3). Conversely, the total protein content and the albumin-globulin fraction (F5) depend mainly on the environment. The α- β- and γ-gliadins (F4) are equally dependent on variety and environment. The subhumid-semiarid agroecological conditions of Constantine (SH-SA) favored an important accumulation of proteins (14.1%), particularly by an increased synthesis of omega gliadins and high-molecular-weight glutenin subunits (HMW-GS), compared to those of Algiers (SH) and Sétif (SA). For these latter environments, metabolic-type proteins are predominant, reflected in a higher F5 fraction (p < 0.05) (albumin and globulin), and significantly more alpha-beta and gamma gliadins. The use of chromatographic analyses to characterize wheat genotypes remains a reliable tool for breeding and variety promotion programs and can provide a better understanding of the ecophysiology of cereal crops.
Efficient Production of Antioxidants from Rape Pollen via a Chromatographic Strategy
Authors: Jin Liugen , Liu Haiqing , Liu Xueliang , Gu Ke , Wu Minchen , Huang Jianfeng
Published: December 2022

Rape pollen has always been considered as a research hotspot in health foods and pharmaceuticals due to its abundance of natural active ingredients. In this work, a compound with antioxidant activity was directly isolated from the methanol extract of rape pollen using a two-step procedure, under the supervision of online HPLC−1,1-diphenyl-2-picrylhydrazyl (HPLC-DPPH) detection. Firstly, online HPLC−DPPH detection was used to identify the active peaks in the methanol extract of rape pollen, and then the methanol extract was pretreated via medium-pressure liquid chromatography (MPLC) to obtain the target fraction 3 (Fr3). Fr3 was further purified using HPLC to finally obtain the target fraction 3-1, which was identified as kaempferol 3,4′-di-O-β-D-glucopyranoside through NMR and mass spectrometry. To further explore the free radical scavenging activity of this compound, its DPPH scavenging ability was determined, and two proteins related to the antioxidant pathway were used for molecular docking. The results revealed that the chromatographic strategy used in this study was efficient and reliable in separating high−purity antioxidants from rape pollen. A strategy such as this, meanwhile, also holds promise for qualitatively identifying and specifically isolating active compounds from other natural products.
Phytochemical, Antimicrobial, Antioxidant, and In Vitro Cytotoxicity Evaluation of Echinops erinaceus Kit Tan
Authors: Sweilam Sherouk Hussein , Abdel Bar Fatma M. , Foudah Ahmed I. , Alqarni Mohammed H. , Elattal Nouran A. , El-Gindi Omayma D. , El-Sherei Moshera M. , Abdel-Sattar Essam
Published: December 2022

Wild plants are used by many cultures for the treatment of diverse ailments. However, they are formed from mixtures of many wanted and unwanted phytochemicals. Thus, there is a necessity to separate the bioactive compounds responsible for their biological activity. In this study, the chemical composition as well as antimicrobial and cytotoxic activities of Echinops erinaceus Kit Tan (Asteraceae) were investigated. This led to the isolation and identification of seven compounds, two of which are new (erinaceosin C3 and erinaceol C5), in addition to methyl oleate (C1) and ethyl oleate (C2), loliolide (C4), (E)-p-coumaric acid (C6), and 5,7,3`,5`-tetrahydroxy flavanone (C7). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HR-ESI-MS. The methanol extract showed the highest antimicrobial activity among the tested extracts and fractions. The n-hexane and EtOAc extracts showed remarkable antimicrobial activity against B. subtilus, P. aeruginosa, E. coli, and C. albicans. A cytotoxicity-guided fractionation of the most bioactive chloroform extract resulted in the isolation of bioactive compounds C1/C2, which showed significant cytotoxicity against HCT-116 and CACO2 cell lines (IC50 24.95 and 19.74 µg/mL, respectively), followed by compounds C3 (IC50 82.82 and 76.70 µg/mL) and C5 (IC50 99.09 and 87.27 µg/mL), respectively. The antioxidant activity of the bioactive chloroform fractions was screened. Molecular docking was used to explain the results of the antimicrobial and anticancer activities against five protein targets, including DNA gyrase topoisomerase II, enoyl-acyl carrier protein reductase of S. aureus (FabI), dihydrofolate reductase (DHFR), β-catenin, and human P-glycoprotein (P-gp).
Correction: Nahkur and Kutsar (2022). Family Type Differences in Children’s Satisfaction with People They Live with and Perceptions about Their (Step)parents’ Parenting Practices. Social Sciences 11: 223
Authors: Nahkur Oliver , Kutsar Dagmar
Published: December 2022

The authors wish to make the following changes to their paper (Nahkur and Kutsar 2022) [...]
A Bibliometric Retrospection of CSR from the Lens of Finance and Economics: Towards Sustainable Development
Authors: Hamid Samreen , Saeed Asif , Farooq Umar , Alnori Faisal
Published: December 2022

Corporate social responsibility (CSR) research is diversified and yet fragmented sustainable development literature. CSR literature is growing at a fast pace in the era of globalization. This article presents a bibliometric analysis of CSR in growing finance and economics literature between 2000 and 2021 using Scopus database extraction of 1134 articles out of 50,435 total articles through lemmatizing, stemming, and clustering. This study used bibliometric coupling to part the research front of CSR and then studied each theme’s conceptual structure and influential aspects separately. The analysis divided the literature into four main themes: (1) CSR performance theme (CSPR), (2) CSR and responsible investment theme (CSRI), (3) CSR market settings theme (CSMS), and (4) CSR and corporate strategy theme (CSCS). This research proposed a future research agenda for the advancement of each theme of CSR in finance and economics. Using meta-literature, 41 future research questions are proposed along with subjective propositions by the authors.
Identifying Villages for Land Consolidation: A New Agricultural Wasteland Concentration Indicator
Authors: Wójcik-Leń Justyna
Published: December 2022

Land consolidation is a process of improving the spatial structure of rural areas, including agricultural wastelands. During work related to this geodesic operation, selected areas can be specified, and the most efficient ways of developing the analysed land can be proposed. Thanks to such rural management work, rural areas can become competitive and start deriving financial benefits from crop cultivation. At the same time, the living standard of their inhabitants is enhanced. The study covered 18 out of 44 villages situated within the administrative limits of the district of Brzozów in the Subcarpathian Voivodeship of south-eastern Poland. An agricultural wasteland concentration indicator was designed for this area based on six factors (soil quality class, agricultural soil complex, slope angle, risk of erosion, water regime, and slope aspect). Each factor was calculated as the total quotient of the weighted feature in relation to the total surface area of the study site. The last stage was a detailed analysis of the area featuring the highest value of the agricultural wasteland indicator—the village of Obarzym. The indicator described in this paper, designed to measure the concentration of agricultural wastelands, can be useful in programming and documenting assumptions for land consolidation to reveal the highest concentration of wasteland. The factors included in this publication refer to soil conditions, terrain relief, and the water regime. Their respective characteristics were designed via multiple calculations using geoprocessing algorithms in GIS software. Various geospatial data provided by district, regional, and national public institutions were used for the calculations. An advantage of the solution is that it can be used in various regions, irrespective of the location of the object to be consolidated.
Developing Sustainable Email Pragmatic Competence for EFL Learners through Reformulation
Authors: Chen Yuan-Shan , Wu Hui-Ju
Published: December 2022

L2 learners’ email requests to authority figures generally contain pragmatic infelicities, requiring corrective feedback to enhance L2 learners’ knowledge of email pragmatics. This study investigated the effectiveness of reformulation, a feedback strategy for writing, for L2 learners of different proficiency levels in an eight-stage collaborative email writing task: (1) composing (pre-test), (2) reformulation and a native speaker model, (3) training, (4) noticing, (5) stimulated recall (reinforcement of noticing), (6) rewriting (the immediate post-test), (7) delayed post-test, and (8) interview. The participants were four pairs of EFL learners, two with high and two with low proficiency in English. The analysis of data included (1) learners’ pair talks, (2) the number of changes noticed and unnoticed by the learners in the reformulations and the native speaker model, (3) the number of revisions matching the reformulations and the native speaker model on the immediate and delayed post-tests, and (4) learners’ responses to interviews. The results suggest that reformulation is effective for L2 learners of different proficiency levels, and the enhanced email competence was sustained for at least four weeks. The learners’ positive perceptions of reformulation also support its effectiveness. In addition, pedagogical implications are provided for language teachers for the implementation of this feedback approach.
The Potential of TikTok’s Key Features as a Pedagogical Strategy for ESL Classrooms
Authors: Tan Kim Hua , Rajendran Agila , Muslim Nazri , Alias Jamsari , Yusof Nor Afian
Published: December 2022

The predominance of the use of the English language on social media entails its potential usefulness in regard to ESL learning. Amongst all social media platforms, none can boast the ubiquity of TikTok. This application has been, and continues to be, one of the largest and most influential social media platforms, as well as a massive success across a range of fields with the most active users in the world. In the field of education, it has the potential to enhance educational pedagogies. Although TikTok has various features aligned to language learning, TikTok’s application within the education field is still largely unexplored. This scoping review aims to identify the key features of TikTok that can be used to enhance pedagogical strategies in sustaining the teaching of language skills in ESL classrooms. Although studies have been conducted on this subject, they have often lacked clarity and also lacked the possibility of synthesis in regard to the contribution of this platform to language education. Thus, this scoping review is conducted in order to identify the useful TikTok elements that strengthened pedagogical strategies in ESL classrooms. A total of 60 publications with publication dates spanning from 2018 to 2021 were chosen from searches on the EBSCOhost, Google Scholar, and ERIC databases in order to illustrate the current state. The outcome of using the identified features of TikTok and key pedagogical TikTok strategies for the purposes of ESL learning were the two themes used to synthesize the data. Findings indicated that video-related features and the duet challenge feature in TikTok have potential in promoting engaging and meaningful learning, in the context of a virtual environment. This potential has enabled the use of major pedagogical strategies, such as digital assignment; active learning; collaborative and team-based learning; experiential learning; and incidental and constructive learning. Although using TikTok is beneficial for the purposes of language learning, the findings of this study also revealed several limitations associated with the platform, such as users’ behavior, poor infrastructure, and an absence of online discussion forums. This review contains suggestions for the purposes of assisting teachers in terms of maximizing their use of TikTok, via overcoming the challenges that were highlighted in previous studies.
Improving Circular Supply Chain Performance through Green Innovations: The Moderating Role of Economic Policy Uncertainty
Authors: Liu Zhaoqian , Wang Mengmeng
Published: December 2022

The sudden outbreak and long-term trend of COVID-19 have brought huge attacks and uncertainty to the global economy, forcing countries to introduce various policies frequently to stimulate economic recovery. To realize sustainable development, firms established an environment-friendly economic development model by building a circular supply chain and implementing a green innovation strategy, which is expected to save resources and protect the environment by recycling resources. Based on this background, this study aims to determine the relationship between the uncertainty of economic policy, green innovation strategy, and circular supply chain performance. It divides green innovation strategies into green product innovation, green process innovation, green service innovation, and green logistics innovation to explore their different impacts on the performance of the circular supply chain. Simultaneously, the moderating effect of uncertainty of economic policy between green innovation and the performance of the circular supply chain is explored. Using survey data collected from 308 manufacturing firms in China, we empirically test the theoretical model and proposed hypotheses through the structural equation modeling approach. Our findings demonstrate that green product innovation, green process innovation, green logistics innovation, and green service innovation have a positive impact on the performance of the circular supply chain. Moreover, we also find that, contrary to our expectations, economic policy uncertainty plays a positive role in moderating the relationship between green innovation and circular supply chain performance. We believe that this paper has a clear contribution to the research on green innovation and circular supply chain management. This study provides a new perspective for the research on the integration of green innovation and circular supply chain, deepens firms’ understanding of green innovation strategy and circular supply chain, and provides important implications and guidance for manufacturing firms to better manage green innovation and circular supply chain practice as well as the risk of economic policy uncertainty.