bluuebunny/crossref_metadata_2025 huggingface dataset:
Atypical deletion of Williams–Beuren syndrome reveals the mechanism of neurodevelopmental disorders
Authors: Zhou Jianrong , Zheng Ying , Liang Guiying , Xu Xiaoli , Liu Jian , Chen Shaoxian , Ge Tongkai , Wen Pengju , Zhang Yong , Liu Xiaoqing , Zhuang Jian , Wu Yueheng , Chen Jimei
Published: April 2022

Genes associated with specific neurocognitive phenotypes in Williams–Beuren syndrome are still controversially discussed. This study identified nine patients with atypical deletions out of 111 patients with Williams–Beuren syndrome; these deletions included seven smaller deletions and two larger deletions. One patient had normal neurodevelopment with a deletion of genes on the distal side of the Williams–Beuren syndrome chromosomal region, includingGTF2IandGTF2IRD1. However, another patient retained these genes but showed neurodevelopmental abnormalities. By comparing the genotypes and phenotypes of patients with typical and atypical deletions and previous reports in the literature, we hypothesize that theBAZ1B,FZD9, andSTX1Agenes may play an important role in the neurodevelopment of patients with WBS.
ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children
Authors: Blankson Samuel Odarkwei , Dadjé Danielle Seri , Traikia Nadjla , Alao Maroufou J. , Ayivi Serge , Amoussou Annick , Deloron Philippe , Ndam Nicaise Tuikue , Milet Jacqueline , Basco Leonardo K. , Aniweh Yaw , Tahar Rachida
Published: April 2022

Background

Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (ICAM-1) as a major receptor for iRBCs binding to P. falciparum erythrocyte membrane protein 1 (PfEMP1) in the development of severe and cerebral malaria. The genetic polymorphism K29M in the immunoglobulin-like domain of ICAM-1, known as ICAM-1Kilifi, has been associated with either increased or decreased risk of developing cerebral malaria.

Methods

To provide more conclusive results, the genetic polymorphism of ICAM-1Kilifi was assessed by PCR and sequencing in blood samples from 215 Beninese children who presented with either mild or severe malaria including cerebral malaria.

Results and conclusions

The results showed that in this cohort of Beninese children, the ICAM-1kilifi variant is present at the frequencies of 0.27, similar to the frequency observed in other African countries. This ICAM-1kilifi variant was not associated with disease severity in agreement with other findings from the Gambia, Tanzania, Malawi, Gabon, and Thailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria.
A phase II trial of stereotactic body radiotherapy in 4 fractions for patients with localized prostate cancer
Authors: Kawakami S. , Tsumura H. , Satoh T. , Tabata K. , Sekiguchi A. , Kainuma T. , Nakano M. , Iwamura M. , Ishiyama H.
Published: April 2022

Purpose/objective(s)

To report results from our phase II study of stereotactic body radiotherapy (SBRT) delivering 36 Gy in 4 fractions for patients with localized prostate cancer.

Materials/methods

We enrolled 55 patients treated with SBRT delivering 36 Gy in 4 fractions between 2015 to 2018. All patients were categorized as low-risk (n = 4), intermediate-risk (n = 31) or high-risk (n = 20) according to National Comprehensive Cancer Network criteria. Median age was 73 years (range 54–86 years). Two-thirds of patients (n = 37) had received androgen-deprivation therapy for 3–46 months (median, 31 months). Median duration of follow-up was 36 months (range 1–54 months). We used Radiation Therapy Oncology Group and National Cancer Institute—Common Toxicity Criteria version 4 for toxicity assessments. Quality of life (QOL) outcomes were also evaluated using the Expanded Prostate Cancer Index Composite (EPIC).

Results

Protocol treatments were completed for all patients. Six patients experienced biochemical failures. Among these six patients, three patients experienced clinical failure. One patient showed bone metastasis before biochemical failure. One patient died of gastric cancer. The 3-year biochemical control rate was 89.8%. Acute grade 2 genitourinary (GU) and gastrointestinal (GI) toxicities were observed in 5 patients (9%) and 6 patients (11%), respectively. No grade 3 or higher acute toxicities were observed. Late grade 2 GU and GI toxicities were observed in 7 patients (13%) and 4 patients (7%), respectively. Late grade 3 GU and GI toxicities were observed in 1 patient (1.8%) each. EPIC scores decreased slightly during the acute phase and recovered within 3 months after treatment.

Conclusion

Our phase II study showed that SBRT delivering 36 Gy in 4 fractions was safe and effective with favorable QOL outcomes, although this regimen showed slightly more severe toxicities compared to current standards.
Long-term survival of two patients with inoperable post-irradiation osteosarcoma treated with carbon-ion radiotherapy: a case report
Authors: Shiba Shintaro , Okamoto Masahiko , Yanagawa Takashi , Kohama Isaku , Shibuya Kei , Okazaki Shohei , Miyasaka Yuhei , Chikuda Hirotaka , Ohno Tatsuya
Published: April 2022

Background

Curative treatment of inoperable post-irradiation sarcoma is often challenging, especially using radiotherapy, wherein curative dose administration is difficult because the organs around the tumor have already been irradiated during the first cancer treatment. Carbon-ion radiotherapy (C-ion RT) might be useful in the treatment of post-irradiation sarcomas because it allows re-irradiation with high-dose localization properties and also demonstrates higher cytotoxic effects on radioresistant tumors compared with X-rays. This study presents the long-term survival of two patients with inoperable post-irradiation pelvic osteosarcoma treated with C-ion RT after uterine cervical cancer treatment.

Case presentation

The durations from prior radiotherapy to the diagnosis of post-irradiation osteosarcoma were 112.8 and 172.2 months, respectively. Both patients received 70.4 Gy (relative biological effectiveness) in 16 fractions of C-ion RT, and chemotherapy was performed before and after C-ion RT. Both patients achieved a complete response 1 year after the initiation of C-ion RT. However, one patient developed single lung metastasis 12.6 months after the initiation of C-ion RT and underwent thoracoscopic lobectomy. After 63.7 and 89.0 months from the initiation of C-ion RT, respectively, the patients were alive with no evidence of local recurrence, other distant metastasis, or fatal toxicities.

Conclusions

The study findings suggest that C-ion RT is a suitable treatment option for inoperable post-irradiation osteosarcoma.
Diagnostic value of platelet indices in infected nonunion: a retrospective study
Authors: Wang Zhen , Mao Hai-Jun , Qiu Xu-Sheng , Chen Yi-Xin , Xu Guang-Yue
Published: April 2022

Background

The diagnostic value of platelet indices has been evaluated in various infectious diseases but not in infected nonunion. The purpose of this study was to assess the usefulness of platelet indices for diagnosis of infected nonunion after open reduction and internal fixation.

Methods

This retrospective study was performed in patients who underwent primary fracture nonunion revision surgeries from January 2016 to December 2021. A total of 297 patients were included in the study: 96 with infected nonunion (group A) and 201 with aseptic nonunion (group B). Receiver operator characteristic (ROC) curve analysis was performed to evaluate diagnostic value of each index. Area under the curve (AUC), sensitivity, specificity, and positive and negative predictive values were calculated and compared.

Results

Demographic characteristics were comparable between the two groups. White blood cell (WBC) count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), plasma fibrinogen, plasma D-dimer, platelet count (PC), plateletcrit, and ratio of platelet count to mean platelet volume (PC/MPV) were significantly higher, and MPV and platelet distribution width (PDW) significantly lower, in group A than in group B (P < 0.05). ROC analysis showed PC/MPV and plasma fibrinogen to have better diagnostic value than the other coagulation indicators (AUC of 0.801 and 0.807, respectively). The combination of ESR, plasma fibrinogen, and PC/MPV had good sensitivity and specificity for diagnosis of infected nonunion. PC/MPV had better diagnostic value than ESR and plasma fibrinogen in the subgroup of patients with coagulation-related comorbidities.

Conclusions

Plasma fibrinogen and PC/MPV ratio might be useful parameters for early diagnosis of infected nonunion.
Evolutionary perspective of drug eluting stents: from thick polymer to polymer free approach
Authors: Hassan Sadia , Ali Murtaza Najabat , Ghafoor Bakhtawar
Published: April 2022

Background

Introduction of Bare Metal Stents (BMS) was itself a revolutionary step in the history of the medical industry; however, Drug Eluting Stents (DES) maintained its superiority over BMS in every aspect from restenosis rate to late lumen loss. The reason behind the magnanimous position of the DES in the stent market is the degree of improvement with which it evolves. New and better stents come into the market every year, surpassing their predecessors by many folds.

Literature review

This review paper discusses the journey of DES with supporting clinical trials in detail. In the first generation, there were stainless-steel stents with thicker coatings. Although they had superior results compared to BMS, there was still room for improvement. Afterward came the second-generation stents, which had superior metal platforms with thinner struts and thin coatings. The drugs were also changed from Paclitaxel and Sirolimus to Zotrolimus and Everolimus. These stents performed best; however, there was an issue of permanent coating, which remained intact over the stent surface after complete drug elution and started to cause issues in longer-term studies. Hence, an improved version of DES was introduced to these permanent coatings called the third generation of drug eluting stents, which initially utilized biodegradable polymer and ultimately moved towards polymer free drug coatings. This generation has introduced a unique amalgam of technologies to achieve its polymer free coatings; however, researchers have numerous prospects of growth in this field. This review paper highlights the major coups of stent technology evolution from BMS to DES, from thick polymeric coatings to thin coatings and from durable polymers to polymer free DES.

Conclusion

In conclusion, though the medical industry promptly accepted BMS as the best treatment option for cardiovascular diseases; however, DES has provided even better results than BMS. In DES, the first and second generation has ruled the technology for many years and are still on the shelves. Still, the issues aroused due to durable polymer shifted the attention towards biodegradable drug eluting stents, the third generation growing rapidly. But the scientific community has not restricted themselves and is investigating bioresorbable stents that completely eliminate the polymer intervention in drug eluting stent technology.
Investigating the mechanism of Xian-ling-lian-xia-fang for inhibiting vasculogenic mimicry in triple negative breast cancer via blocking VEGF/MMPs pathway
Authors: Li Feifei , Shi Youyang , Zhang Yang , Yang Xiaojuan , Wang Yi , Jiang Kexin , Hua Ciyi , Wu Chunyu , Sun Chenping , Qin Yuenong , Liu Sheng
Published: April 2022

Background

Xian-ling-lian-xia-fang (XLLXF), a Chinese medicine decoction, is widely used in the treatment of triple negative breast cancer (TNBC). However, the underlying mechanism of XLLXF in TNBC treatment has not been totally elucidated.

Methods

Here, network pharmacology and molecular docking were used to explore the mechanism of Traditional Chinese medicine in the treatment of TNBC. Then, biological experiments were integrated to verify the results of network pharmacology.

Results

Network pharmacology showed that the candidate active ingredients mainly included quercetin, kaempferol, stigmasterol, and β-sitosterol through the “XLLXF–active ingredients–targets” network. Vascular endothelial growth factor A (VEGFA) and matrix metalloproteinase (MMP) 2 were the potential therapeutic targets obtained through the protein–protein interaction (PPI) network. Molecular docking confirmed that quercetin, kaempferol, stigmasterol, and β-sitosterol could stably combine with VEGFA and MMP2. Experimental verification showed that XLLXF could inhibit proliferation, colony ability, and vasculogenic mimicry (VM) formation and promote cell apoptosis in TNBC. Laser confocal microscopy found that XLLXF impaired F-actin cytoskeleton organization and inhibited epithelial mesenchymal transition. Animal experiments also found that XLLXF could inhibit tumor growth and VM formation in TNBC xenograft model. Western blot analysis and immunohistochemical staining showed that XLLXF inhibited the protein expression of VEGFA, MMP2, MMP9, Vimentin, VE-cadherin, and Twist1 and increased that of E-cadherin, tissue inhibitors of metalloproteinase (TIMP)-1, and TIMP-3 in vitro and in vivo.

Conclusions

Integrating the analysis of network pharmacology and experimental validation revealed that XLLXF could inhibit VM formation via downregulating the VEGF/MMPs signaling pathway.
How can we best help this patient? Exploring mental health therapists’ reflections on medication-free care for patients with psychosis in Norway
Authors: Oedegaard Christine Henriksen , Ruano Ana Lorena , Blindheim Anne , Veseth Marius , Stige Brynjulf , Davidson Larry , Engebretsen Ingunn Marie Stadskleiv
Published: April 2022

Background

Since 2015, Norwegian Regional Health Authorities have followed new government policy and gradually implemented medication-free services for patients with psychosis. The aim of this qualitative study was to explore the tension between policy and practice, and how health care workers in Bergen reflect on their role in implementing medication-free treatment.

Methods

We performed three focus group discussions including 17 therapists working within medication free services, asking about their experiences with this new treatment program. We used Systematic Text Condensation for data analysis. The findings were discussed using Michael Lipsky’s theoretical framework on the role public health workers play in policy implementation.

Findings

Following Norway’s new policy was challenging for the therapists in our study, particularly balancing a patient’s needs with treatment guidelines, the legal framework and available resources. Therapists had an overarching wish to help patients through cooperation and therapeutic alliance, but their alliance was sometimes fragile, and the therapists worried about patients’ conditions worsening.

Conclusions

Democratization of treatment choices, with the aim of empowering patients in mental health care, challenges the level of professional discretion given that patients and therapists might have conflicting goals. Balancing the desire to help, professional responsibility, the perceived lack of resources, and certain patient choices created conditions that can leave therapists feeling disempowered in and alienated from their work.

Trial registration: N/A.
The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study
Authors: Wang Sheng-Huei , Yang Kuang-Yao , Sheu Chau-Chyun , Chen Wei-Cheng , Chan Ming-Cheng , Feng Jia-Yih , Chen Chia-Min , Wu Biing-Ru , Zheng Zhe-Rong , Chou Yu-Ching , Peng Chung-Kan ,   the T.-CARE (Taiwan Critical Care, Infection) Group
Published: April 2022

Background

The importance or necessity of a loading dose when prescribing intravenous colistin has not been well established in clinical practice, and approximate one-third to half of patients with carbapenem-resistant gram-negative bacteria (CRGNB) infection did not receive the administration of a loading dose. The aim of this study is to investigate the efficacy and risk of acute kidney injury when prescribing intravenous colistin for critically ill patients with nosocomial pneumonia caused by CRGNB.

Methods

This was a multicenter, retrospective study that recruited ICU-admitted patients who had CRGNB-associated nosocomial pneumonia and were treated with intravenous colistin. Then, we classified the patients into colistin loading dose (N = 85) and nonloading dose groups (N = 127). After propensity-score matching for important covariates, we compared the mortality rate, clinical outcome and microbiological eradication rates between the groups (N = 67).

Results

The loading group had higher percentages of patients with favorable clinical outcomes (55.2% and 35.8%, p = 0.037) and microbiological eradication rates (50% and 27.3%, p = 0.042) at day 14 than the nonloading group. The mortality rates at days 7, 14 and 28 and overall in-hospital mortality were not different between the two groups, but the Kaplan–Meier analysis showed that the loading group had a longer survival time than the nonloading group. Furthermore, the loading group had a shorter length of hospital stay than the nonloading group (52 and 60, p = 0.037). Regarding nephrotoxicity, there was no significant difference in the risk of developing acute kidney injury between the groups.

Conclusions

The administration of a loading dose is recommended when prescribing intravenous colistin for critically ill patients with nosocomial pneumonia caused by CRGNB.
Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing
Authors: Shi Yue , Zhang Qi , Bi Hai , Lu Min , Tan Yezhen , Zou Daojia , Ge Liyuan , Chen Zhigang , Liu Cheng , Ci Weimin , Ma Lulin
Published: March 2022

Background

Vascular invasion with tumor thrombus frequently occurs in advanced renal cell carcinoma (RCC). Thrombectomy is one of the most challenging surgeries with high rate of perioperative morbidity and mortality. However, the mechanisms driving tumor thrombus formation are poorly understood which is required for designing effective therapy for eliminating tumor thrombus.

Results

We perform single-cell RNA sequencing analysis of 19 surgical tissue specimens from 8 clear cell renal cell carcinoma (ccRCC) patients with tumor thrombus. We observe tumor thrombus has increased tissue resident CD8+ T cells with a progenitor exhausted phenotype compared with the matched primary tumors. Remarkably, macrophages, malignant cells, endothelial cells and myofibroblasts from TTs exhibit enhanced remodeling of the extracellular matrix. The macrophages and malignant cells from primary tumors represent proinflammatory states, but also increase the expression of immunosuppressive markers compared to tumor thrombus. Finally, differential gene expression and interaction analyses reveal that tumor-stroma interplay reshapes the extracellular matrix in tumor thrombus associated with poor survival.

Conclusions

Our comprehensive picture of the ecosystem of ccRCC with tumor thrombus provides deeper insights into the mechanisms of tumor thrombus formation, which may aid in the design of effective neoadjuvant therapy to promote downstaging of tumor thrombus and decrease the perioperative morbidity and mortality of thrombectomy.
Development of a core outcome set for effectiveness studies of breech birth at term (Breech-COS)—an international multi-stakeholder Delphi study: study protocol
Authors: Walker Shawn , Dasgupta Tisha , Shennan Andrew , Sandall Jane , Bunce Catey , Roberts Phoebe
Published: April 2022

Background

Women pregnant with a breech-presenting foetus at term are at increased risk of adverse pregnancy outcomes. The most common intervention used to improve neonatal outcomes is planned delivery by caesarean section. But this is not always possible, and some women prefer to plan a vaginal birth. A number of providers have proposed alternative interventions, such as delivery protocols or specialist teams, but heterogeneity in reported outcomes and their measurements prevents meaningful comparisons. The aim of this paper is to present a protocol for a study to develop a Breech Core Outcome Set (Breech-COS) for studies evaluating the effectiveness of interventions to improve outcomes associated with term breech birth.

Methods

The development of a Breech-COS includes three phases. First, a systematic literature review will be conducted to identify outcomes previously used in effectiveness studies of breech birth at term. A focus group discussion will be conducted with the study’s pre-established Patient and Public Involvement (PPI) group, to enable service user perspectives on the results of the literature review to influence the design of the Delphi survey instrument. Second, an international Delphi survey will be conducted to prioritise outcomes for inclusion in the Breech-COS from the point of view of key stakeholders, including perinatal care providers and families who have experienced a term breech pregnancy. Finally, a consensus meeting will be held with stakeholders to ratify the Breech-COS and disseminate findings for application in future effectiveness studies.

Discussion

The expectation is that the Breech-COS will always be collected in all clinical trials, audits of practice and other forms of observation research that concern breech birth at term, along with other outcomes of interest. This will facilitate comparing, contrasting and combining studies with the ultimate goal of improved maternal and neonatal outcomes.

Trial registration

Core Outcome Measures in Effectiveness Trials (COMET) #1749
The Mirasol Evaluation of Reduction in Infections Trial (MERIT): study protocol for a randomized controlled clinical trial
Authors: Kasirye Ronnie , Hume Heather A. , Bloch Evan M. , Lubega Irene , Kyeyune Dorothy , Shrestha Ruchee , Ddungu Henry , Musana Hellen Wambongo , Dhabangi Aggrey , Ouma Joseph , Eroju Priscilla , de Lange Telsa , Tartakovsky Michael , White Jodie L. , Kakura Ceasar , Fowler Mary Glenn , Musoke Philippa , Nolan Monica , Grabowski M. Kate , Moulton Lawrence H. , Stramer Susan L. , Whitby Denise , Zimmerman Peter A. , Wabwire Deo , Kajja Isaac , McCullough Jeffrey , Goodrich Raymond , Quinn Thomas C. , Cortes Robert , Ness Paul M. , Tobian Aaron A. R.
Published: April 2022

Background

Transfusion-transmitted infections (TTIs) are a global health challenge. One new approach to reduce TTIs is the use of pathogen reduction technology (PRT). In vitro, Mirasol PRT reduces the infectious load in whole blood (WB) by at least 99%. However, there are limited in vivo data on the safety and efficacy of Mirasol PRT. The objective of the Mirasol Evaluation of Reduction in Infections Trial (MERIT) is to investigate whether Mirasol PRT of WB can prevent seven targeted TTIs (malaria, bacteria, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, hepatitis E virus, and human herpesvirus 8).

Methods

MERIT is a randomized, double-blinded, controlled clinical trial. Recruitment started in November 2019 and is expected to end in 2024. Consenting participants who require transfusion as medically indicated at three hospitals in Kampala, Uganda, will be randomized to receive either Mirasol-treated WB (n = 1000) or standard WB (n = 1000). TTI testing will be performed on donor units and recipients (pre-transfusion and day 2, day 7, week 4, and week 10 after transfusion). The primary endpoint is the cumulative incidence of one or more targeted TTIs from the Mirasol-treated WB vs. standard WB in a previously negative recipient for the specific TTI that is also detected in the donor unit. Log-binomial regression models will be used to estimate the relative risk reduction of a TTI by 10 weeks associated with Mirasol PRT. The clinical effectiveness of Mirasol WB compared to standard WB products in recipients will also be evaluated.

Discussion

Screening infrastructure for TTIs in low-resource settings has gaps, even for major TTIs. PRT presents a fast, potentially cost-effective, and easy-to-use technology to improve blood safety. MERIT is the largest clinical trial designed to evaluate the use of Mirasol PRT for WB. In addition, this trial will provide data on TTIs in Uganda.

Trial registration

Mirasol Evaluation of Reduction in Infections Trial (MERIT) NCT03737669. Registered on 9 November 2018
A deprescribing medication program to evaluate falls in older adults: methods for a randomized pragmatic clinical trial
Authors: Niznik Joshua , Ferreri Stefanie P. , Armistead Lori , Urick Benjamin , Vest Mary-Haston , Zhao Liang , Hughes Tamera , McBride J. Marvin , Busby-Whitehead Jan
Published: April 2022

Background

Opioids and benzodiazepines (BZDs) are some of the most commonly prescribed medications that contribute to falls in older adults. These medications are challenging to appropriately prescribe and monitor, with little guidance on safe prescribing of these medications for older patients. Only a handful of small studies have evaluated whether reducing opioid and BZD use through deprescribing has a positive impact on outcomes. Leveraging the strengths of a large health system, we evaluated the impact of a targeted consultant pharmacist intervention to deprescribe opioids and BZDs for older adults seen in primary care practices in North Carolina.

Methods

We developed a toolkit and process for deprescribing opioids and BZDs in older adults based on a literature review and guidance from an interprofessional team of pharmacists, geriatricians, and investigators. A total of fifteen primary care practices have been randomized to receive the targeted consultant pharmacist service (n = 8) or usual care (n = 7). The intervention consists of several components: (1) weekly automated reports to identify chronic users of opioids and BZDs, (2) clinical pharmacist medication review, and (3) recommendations for deprescribing and/or alternate therapies routed to prescribers through the electronic health record. We will collect data for all patients presenting one of the primary care clinics who meet the criteria for chronic use of opioids and/or BZDs, based on their prescription order history. We will use the year prior to evaluate baseline medication exposures using morphine milligram equivalents (MMEs) and diazepam milligram equivalents (DMEs). In the year following the intervention, we will evaluate changes in medication exposures and medication discontinuations between control and intervention clinics. Incident falls will be evaluated as a secondary outcome. To date, the study has enrolled 914 chronic opioid users and 1048 chronic BZD users. We anticipate that we will have 80% power to detect a 30% reduction in MMEs or DMEs.

Discussion

This clinic randomized pragmatic trial will contribute valuable evidence regarding the impact of pharmacist interventions to reduce falls in older adults through deprescribing of opioids and BZDs in primary care settings.

Trial registration

Clinicaltrials.govNCT04272671. Registered on February 17, 2020
Family caregiving and chronic illness management in schizophrenia: positive and negative aspects of caregiving
Authors: Peng Man-Man , Ma Zhiying , Ran Mao-Sheng
Published: March 2022

Background

We aimed to explore the long-term caregiving experiences of family caregivers of people with schizophrenia (PwS) in terms of both positive and negative aspects.

Method

Utilising a purposive sampling method, we conducted in-depth interviews with 20 family caregivers of persons who had suffered from schizophrenia for more than 20 years. We empirically investigated their retrospective experiences of caregiver-patient interactions during a long period of family caregiving. We audio-recorded and transcribed the interviews into text. We thematically coded and analysed the transcribed text using a four-phase method of theme development.

Findings

Schizophrenia might not only generate a caregiving burden, affect caregivers’ psychological status, and accordingly influence their coping strategies, but also have short- or long-term patient-related consequences.

Discussion

Family caregivers should develop their stress management skills to cope with relevant life changes and increase their knowledge of the potential psychological consequences for care recipients resulting from negative caregiving strategies during home-based practice. Care recipients with schizophrenia in a relatively stable status should be empowered to take care of themselves. More effective family-based interventions for psychiatric nursing or individualised training for symptom management should be tailored to serve families’ diverse needs.
Impact of massive neutron star radii on the nature of phase transitions in dense matter
Authors: Somasundaram R. , Margueron J.
Published: April 2022

The last few years have seen tremendous progress in the observation of the global properties of neutron stars (NSs), e.g., masses, radii and tidal deformabilities. Such properties provide information about possible phase transitions in the inner cores of NSs, provided the connection between observed masses and radii and the equation of state (EoS) is well understood. We focus the present study on first-order phase transition, which often softens the EoS and consequently reduces the maximum mass as well as the radii of NSs. Here, we challenge this conventional expectation by constructing explicit examples of EoSs undergoing a first-order phase transition, but which are much stiffer that their purely hadronic counterparts. We also provide comparisons with the recently proposed quarkyonic EoS which suggests a strong repulsion in the core of NSs, and we show that their stiffness can be realistically masqueraded by stiff first-order phase transitions to exotic matter.
Adult Stature and Protein Intake During Childhood and Adolescence From 3 Years Onward
Authors: Hua Yifan , Remer Thomas
Published: March 2022

Context

Varying protein intake is known to influence human height growth. However, whether a habitually higher protein intake consistently above dietary recommendations during childhood and adolescence affects adult stature is not known.

Objective

To examine whether protein intake in excess of recommendations from childhood onward may exert an anabolic effect on adult stature.

Methods

We examined habitual protein intake based on 3-day weighed dietary records and 24-hour urinary biomarker excretions in a longitudinal cohort of 189 healthy individuals aged between 3 and 17 years (analyzing 11 diet recordings and 11 24-urine samples per child on average). Urinary urea nitrogen (uN) excretion was used as a biomarker for protein intake. Multilinear regressions were applied to examine the prospective associations of average total and average animal protein intake during growth with the outcome adult height (AH) after adjusting for parental heights, energy intake, dietary potential renal acid load (PRAL), and pubertal, early-life, and socioeconomic factors.

Results

Mean SD scores of total (P = .001) and animal (P < .0001) protein intake as well as uN (P = .01) were prospectively and independently related to adult height in girls, but not in boys. Also for girls only, the fully adjusted regression for renal biomarkers (R2total = 0.79) indicated an inverse relationship between AH and the urinary biomarker for dietary acidity PRAL (P = .06).

Conclusion

Our prospective, biomarker-confirmed findings on habitual protein intake during the pediatric period provide evidence that protein ingestion above dietary recommendation contributes to an enhanced AH in girls. This enhancement, in turn, may be weakened by an insufficient alkalizing potential through PRAL-raising fruit- and vegetable-poor nutrition.
Quantitative Fluorescent Detection of Antibacterial Activity with Pyrene-Bearing Tannic Acid
Authors: Fujita Takehiro , Hasegawa Jun , Onoue Miki , Matsubara Ryohei , Yamamoto Takako , Naito Masanobu
Published: March 2022

Quantitative evaluation of the antibacterial activity of conventional antibacterial agents in situ is difficult. In this study, we demonstrated that antibacterial activity can be quantitatively estimated from the photoluminescence intensity of pyrene fluorophores incorporated into tannic acid, a naturally occurring antibacterial agent.
Atlas-based relaxometry and subsegment analysis of the substantia nigra pars compacta using quantitative MRI: a healthy volunteer study
Authors: Fujiwara Yasuhiro , Ishida Shota , Matta Yuki , Kanamoto Masayuki , Kimura Hirohiko
Published: March 2022

Objective:

Parkinson’s disease is a neurodegenerative disorder caused by neuronal cell loss in the substantia nigra pars compacta (SNpc). We aimed to perform atlas-based relaxometry using an anatomical SNpc atlas and obtain baseline values of SNpc regions in healthy volunteers.

Methods:

Neuromelanin (NM)-sensitive imaging of the midbrain and whole-brain 3D T1 weighted images of 27 healthy volunteers (20 males; aged 36.3 ± 11.5 years) were obtained. An anatomical SNpc atlas was created using NM-sensitive images in standard space, and divided into medial (MG), dorsal (DG), and ventrolateral (VG) groups. Proton density (PD), T1, and T2 values in these regions were obtained using quantitative MRI. The relationships between PD, T1, and T2 values in each SNpc region and age were evaluated.

Results:

The VG PD value was significantly higher than the MG and DG values. MG, DG, and VG T1 values were significantly different, whereas the T2 value of the MG was significantly lower than the DG and VG values. Moreover, a significant negative correlation between PD and T1 values of the MG and age was observed.

Conclusion:

The PD, T1, and T2 values of the SNpc regions measured in standard space using an anatomical atlas can be used as baseline values. PD and T1 values of the SNpc regions may be associated with NM concentrations.

Advances in knowledge:

An anatomical SNpc atlas was created using NM-sensitive MRI and can be used for the quantitative evaluation of subsegments of the SNpc in standard space.
Punkt widzenia autora recenzji naukowej na okładce książki humanistycznej
Authors: Wołoszyn Magdalena
Published: March 2022

Recenzja na okładce książki stanowi ekscerpt z recenzji wydawniczej i jednocześnie rodzaj paratekstu prezentującego konkretną książkę i zachęcającego potencjalnego odbiorcę do lektury. Autorka analizuje różne punkty widzenia obecne w recenzji naukowej zamieszczonej na okładce książki humanistycznej. Analiza zamieszczonych na okładkach wybranych tekstów recenzji wykazała, że są w nich obecne podmiotowe punkty widzenia, m.in.: eksperta, autorytetu w danej dziedzinie, badacza ze stopniem i/lub tytułem naukowym, osoby świeckiej lub duchownej. Wymienione punkty widzenia harmonijnie łączą się ze sobą i wzajemnie uzupełniają, dając specjalistyczne spojrzenie i rzetelną opinię o przedmiocie poddawanym recenzji.
Klasyczny reportaż podróżniczy w sieci. Arkady Fiedler i jego czytelnicy w internecie
Authors: Uljasz Adrian
Published: March 2022

Tematem artykułu jest recepcja internetowa postaci i dorobku słynnego polskiego podróżnika – reportera i pisarza Arkadego Fiedlera (1894–1985), a także promocja i dostępność jego reportaży podróżniczych w internecie. Twórczość pisarza wciąż spotyka się z zainteresowaniem czytelniczym. Ważnym zagadnieniem jest popularyzacja autora i jego książek w sieci internetowej, głównie prowadzona za pośrednictwem strony Muzeum Pracowni Literackiej Arkadego Fiedlera w Puszczykowie w Wielkopolsce. W artykule omówiono też kwestię dostępności jego publikacji w ofercie księgarskiej, w tym w formie e-booków, a także metody promocji, stosowane przez księgarzy w sieci internetowej. Zwrócono uwagę na zagadnienie udostępniania książek A. Fiedlera w serwisie Legimi. Odniesiono się do sprawy dostępności publikacji pisarza w internecie, w tym w bazach o otwartym dostępie. Przeanalizowano popularność reportaży A. Fiedlera w obiegu czytelniczym – bibliotecznym i pozabibliotecznym na podstawie badań, przeprowadzonych na portalu internetowym W bibliotece.pl oraz na internetowych portalach czytelniczych.
Scorecard and KPIs for monitoring software factories effectiveness in the financial sector
Authors: Rodríguez Montequín Vicente , Álvarez Pérez César , Ortega Fernández Francisco , Villanueva Balsera Joaquín
Published: March 2022

Financial corporations and especially banking institutions have important needs concerning to the development of software around their business core. The software, that traditionally had been developed in house by the IT departments, is now usually outsourced to IT firms. These firms work under the software factories model. An important feature within this sector is that usually the financial groups keep the ownership of these firms because the strategic value of the software for the core business. These firms work almost exclusively for the owner financial group developing their software, but they have to demonstrate that they are so profitable and competitive like any other firm. The organizational structure of these firms has some differential features. Top level tasks (software design and project management) are usually performed by the IT firm but the development is usually subcontracted to other software companies. Although financial corporations have always paid a special interest to investing in management and organizational policies to improve their efficiency, there have being always an important lack regarding to the control and monitoring of the software projects. They do not have suitable tools for monitoring actual process effectiveness. Adapting scorecards to this environment could be a useful tool for monitoring and improvement the process. Scorecard could here be used both as a tool for internal effectiveness measurement as well as externally, presenting sustainabilityindicators for the shareholders, the financial institutions. This paper aims to identify and define a collection of Key Performance Indicators which permit effectiveness to be improved under this context, focusing in the specific supplychain model given by owner (financial group), software factory and software developers (subcontracted).
The path towards discovering PMO: an exploratory analysis of the Italian banking sector
Authors: Pansini Federica , Terzieva Mariya , Morabito Vincenzo
Published: March 2022

Directly acting on Project Management practices, PMO provides companies with help to innovate, reaching competitive advantage and growth in the long run, ceteris paribus, and attempts to reduce uncertainty. Even though PMO is a more consolidated practice in some countries, the phenomenon has lately been introduced in Italy, and it is still evolving. Not all organizations and not all individuals clearly understand the potential of PMO, and its role is often limited to simple Project Management in its strict meaning, while areas for improvement are many and varied. The paper analyses the status of PMO through a survey conducted inside the Italian banking sector, trying to frame the role of PMO, throwing light on its importance for a company as a whole, and not just for a single project. A discussion of the results and future work concludes the paper.
A catalog of information systems outsourcing risks
Authors: Sá-Soares Filipe de , Soares Delfina , Arnaud José
Published: March 2022

Information systems outsourcing risks are a vital component in the decision and management process associated to the provision of information systems and technology services by a provider to a customer. Although there is a rich literature on information systems outsourcing risks, the accumulated knowledge on this area is fragmented. In view of this situation, an argument is put forward on the usefulness of having a theory that integrates the various constructs related to information systems outsourcing risks. This study aims to contribute towards the synthesis of that theory, by proposing a conceptual framework for interpreting the literature and presenting a catalog of information systems outsourcing risks. The conceptual framework articulates together six key risk elements, namely dangers, negative outcomes, undesirable consequences, factors and mitigation actions. The catalog condenses and categorizes the information systems outsourcing risk elements found on the literature reviewed, both from the perspective of the outsourcing customer and from the perspective of the outsourcing provider. Proposals for subsequent work towards the generation of the theory of information systems outsourcing risk are suggested.
Resource allocation in IT projects: using schedule optimization
Authors: Chilton Michael A.
Published: March 2022

Resource allocation is the process of assigning resources to tasks throughout the life of a project. Despite sophisticated software packages devoted to keeping track of tasks, resources and resource assignments, it is often the case that project managers find some resources over-allocated and therefore unable to complete the assigned work in the allotted amount of time. Most scheduling software has provisions for leveling resources, but the techniques for doing so simply add time to the schedule and may cause delays in tasks that are critical to the project in meeting deadlines. This paper presents a software application that ensures that resources are properly balanced at the beginning of the project and eliminates the situation in which resources become over-allocated. It can be used in a multi-project environment and reused throughout the project as tasks, resource assignments and availability, and the project scope change. The application utilizes the bounded enumeration technique to formulate an optimal schedule for which both the task sequence and resource availability are taken into account. It is run on a database server to reduce the running time and make it a viable application for practitioners.
Sourcing strategies to keep up with competition: the case of SAP
Authors: Antero Michelle , Hedman Jonas , Henningsson Stefan
Published: March 2022

This paper applies the Red Queen theory to explain how organizations utilize various sourcing arrangements in order to compete in an evolutionary arms race where only the strongest competitors will survive. The case study incorporates competition, and views sourcing strategies as a means to improve the firm’s viability to survive competition in the marketplace. The study begins by positioning the Red Queen theory within the sourcing literature. It subsequently applies the framework to a case study of SAP AG to illustrate how sourcing strategies have changed over time in response to the logic of competition. The case study reveals that (a) organizations are adaptive systems and capable of learning to make strategic changes pertaining to sourcing arrangements; (b) organizations select the terms on which they want to compete by developing certain capabilities within the firm; (c) organizations are reflexive and over time develop competitive hysteresis which allows them to become stronger competitors. In the case of SAP AG, various sourcing arrangements were selected over its 40-year history to respond to technological and market changes.
Distributed team cohesion – not an oxymoron. The impact of information and communications technologies on teamness in globally distributed IT projects
Authors: Stawnicza Olga
Published: March 2022

Globally distributed IT projects are common practice in today’s globalized world. Typically, project team members work on interdependent tasks, with a common goal to be achieved as one team. However, being split between multiple locations impedes communication among team members and hampers the development of trust. Information and communications media enable communication between geographically distributed project team members and help to create and maintain trust within project units. Communication and trust are particularly significant for fostering a feeling of oneness among project team members. Oneness, also referred to as “teamness”, is repeatedly mentioned as one of the challenges facing global project teams. However, prior literature on teamness is very scarce and its importance is underrepresented. This research contributes to the field in two ways. First, the theoretical study based on a systematic literature review examines available evidence of teamness in globally distributed projects. Secondly, an empirical study based on interviews conducted with global project managers fills the current gap in literature on the link between use of ICT and establishing a sense of team unity. This paper draws practitioners’ attention to the importance of striving for teamness in spite of the geographical distance that exists between project team members.
Towards holistic goal centered performance management in software development: lessons from a best practice analysis
Authors: Murphy Thomas , Cormican Kathryn
Published: March 2022

There are strong motivating factors for more effective performance measurement practices in software development. Astute practices in this domain are lauded to improve efficiency and effectiveness. However previous studies have shown that measurement in software is intricate, complex and fraught with challenges. Consequently it is poorly managed in practice. Our research seeks to better understand performance management in a real world software development setting in order to identify the challenges and generate a roadmap for improvement. This paper presents findings from an inductive analysis of a radical measurement program in a global software organization. Our study investigates the level at which non-compliance with best practice can explain the company’s disappointing results. We found that a narrow focus on projects, rather than on organizational goals, has seriously hindered its success. We also found that the rate of change in the organization as a whole was impinging on the effective implementation of its measurement program. An analysis of the results demonstrates just how challenging software measurement is. The findings provide an evaluation of best practice relative to the literature that is informed by real industry experience.
An extension of the technology acceptance model for business intelligence systems: project management maturity perspective
Authors: Bach Mirjana Pejić , Zoroja Jovana , Čeljo Amer
Published: March 2022

Business intelligence systems (BISs) refer to a wide range of technologies and applications useful for retrieving and analyzing a large amount of information with the goal to generate knowledge useful for making effective business decision. In order to investigate adoption of BISs in companies, we propose a model based on the technology acceptance model (TAM) that is expanded by variables representing the concept of a project management maturity (PMM). The survey on the sample of USA companies has been conducted with the chief information officer (CIO) as the main informant. A structural equation model has been developed in order to test the research model. Results indicate that TAM expanded with the notion of PMM is useful in increasing understanding of BISs adoption in companies.