bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of mHealth aided 12-week meditation and breath intervention on change in burnout and professional quality of life among health care providers of a tertiary care hospital in north India: a randomized waitlist-controlled trial
Authors: Bhardwaj Praag , Pathania Monika , Bahurupi Yogesh , Kanchibhotla Divya , Harsora Prateek , Rathaur Vyas Kumar
Published: November 2023

Introduction

Burnout is “Chronic workplace stress that has not been successfully managed.” Professional quality of life (PQL) includes work related experiences of compassion satisfaction and compassion fatigue. Healthcare providers (HCPs) are highly susceptible to burnout and compassion fatigue due to their demanding work, which lowers PQL. Burnout leads to poor care, medical errors, and patient safety across healthcare disciplines. Yoga has been shown to improve resilience, reduce stress, and increase self-compassion and psycho-physiological coherence. This study compared HCPs in a mHealth-aided 12-week yoga-based meditation and breath intervention to waitlist controls for HCP burnout and PQL at a north Indian tertiary care hospital.

Methods

This was randomized waitlist-controlled trial. Total 98 HCPs (62 males and 36 females) with an average age of 28.26 ± 3.547 years were enrolled consecutively from March 2021 to November 2022. Randomization was done with opaque sealed envelopes numbered in a computer-generated sequence. The experimental group (n = 49) received 12 online weekly yoga sessions and performed daily home practice (6 days a week). The waitlisted control group (n = 49) continued their daily routine. Maslach’s burnout inventory (MBI), professional quality of life (PQL) and anthropometric measurements were assessed at baseline and after 12 weeks.

Results

After 12 weeks, the MBI outcomes of emotional exhaustion, depersonalization, and personal accomplishment showed a highly significant difference between the two groups (p < 0.001). PQL outcomes of compassion satisfaction, burnout, and secondary trauma also differed significantly (p < 0.001). Within group analysis showed that MBI and PQL outcomes improved significantly (p < 0.001) for the experimental group after 12 weeks.

Conclusion

The current study contributes to the existing evidence on the effectiveness of Yoga in managing stress and developing resilience among doctors, nurses, and other medical professionals. Integrating yoga into healthcare settings is crucial for addressing the detrimental impact of burnout on decision-making and promoting positive patient outcomes. mHealth technologies have the potential to enhance the user-friendliness of yoga-based interventions by personalizing the practice space and time. Yoga-based interventions and mHealth technologies can effectively address physician burnout, in a simple and implementable manner.
Configurations of human-centered AI at work: seven actor-structure engagements in organizations
Authors: Wilkens Uta , Lupp Daniel , Langholf Valentin
Published: November 2023

Purpose

The discourse on the human-centricity of AI at work needs contextualization. The aim of this study is to distinguish prevalent criteria of human-centricity for AI applications in the scientific discourse and to relate them to the work contexts for which they are specifically intended. This leads to configurations of actor-structure engagements that foster human-centricity in the workplace.

Theoretical foundation

The study applies configurational theory to sociotechnical systems’ analysis of work settings. The assumption is that different approaches to promote human-centricity coexist, depending on the stakeholders responsible for their application.

Method

The exploration of criteria indicating human-centricity and their synthesis into configurations is based on a cross-disciplinary literature review following a systematic search strategy and a deductive-inductive qualitative content analysis of 101 research articles.

Results

The article outlines eight criteria of human-centricity, two of which face challenges of human-centered technology development (trustworthiness and explainability), three challenges of human-centered employee development (prevention of job loss, health, and human agency and augmentation), and three challenges of human-centered organizational development (compensation of systems’ weaknesses, integration of user-domain knowledge, accountability, and safety culture). The configurational theory allows contextualization of these criteria from a higher-order perspective and leads to seven configurations of actor-structure engagements in terms of engagement for (1) data and technostructure, (2) operational process optimization, (3) operators’ employment, (4) employees’ wellbeing, (5) proficiency, (6) accountability, and (7) interactive cross-domain design. Each has one criterion of human-centricity in the foreground. Trustworthiness does not build its own configuration but is proposed to be a necessary condition in all seven configurations.

Discussion

The article contextualizes the overall debate on human-centricity and allows us to specify stakeholder-related engagements and how these complement each other. This is of high value for practitioners bringing human-centricity to the workplace and allows them to compare which criteria are considered in transnational declarations, international norms and standards, or company guidelines.
Outcomes of liver transplantation with thoracoabdominal normothermic regional perfusion: a matched-controlled initial experience in Spain
Authors: Secanella Luis , Alconchel Felipe , López-Monclús Javier , Toledo-Martínez Enrique , Barrios Oriana , Ramírez Pablo , Jiménez-Garrido Manuel Cecilio , Rodríguez-Sanjuán Juan Carlos , Royo-Villanova Mario , Moreno-González Gabriel , Lladó Laura
Published: November 2023

Thoracoabdominal (TA) normothermic regional perfusion (NRP) should allow the safe recovery of heart and liver grafts simultaneously in the context of controlled donation after circulatory death (cDCD). We present the initial results of cDCD liver transplantation with simultaneous liver and heart procurement in Spain until October 2021. Outcomes were compared with a matched cohort of cDCD with abdominal NRP (A-NRP) from participating institutions. Primary endpoints comprised early allograft dysfunction (EAD) or primary non-function (PNF), and the development of ischemic-type biliary lesions (ITBL). Six transplants were performed using cDCD with TA-NRP during the study period. Donors were significantly younger in the TA-NRP group than in the A-NRP group (median 45.6 years and 62.9 years respectively, p = 0.011), with a median functional warm ischemia time of 12.5 min in the study group and 13 min in the control group. Patient characteristics, procurement times, and surgical baseline characteristics did not differ significantly between groups. No patient in the study group developed EAD or PNF, and over a median follow-up of 9.8 months, none developed ITBL or graft loss. Extending A-NRP to TA-NRP for cardiac procurement may be technically challenging, but it is both feasible and safe, showing comparable postoperative outcomes to A-NRP.
Developing improvement strategies for management of the Sisrè berry plant [Synsepalum dulcificum (Schumach & Thonn.) Daniell] based on end-users’ preferences in Southern Nigeria
Authors: Tchokponhoué Dèdéou A. , Legba Eric C. , N’Danikou Sognigbé , Nyadanu Daniel , Oselebe Happiness O. , Achigan-Dako Enoch G.
Published: November 2023

Synsepalum dulcificum is a valuable horticultural and lesser-known crop, famous for the uniqueness of its taste modifying properties, which is candidate for genetic improvement in West Africa. Semi-structured interviews were conducted with 100 respondents purposively selected to analyze the current production systems and constraints as well as to document the farmers’ and consumers’ preferences for breeding traits in Southern Nigeria. The results showed that none of the investigated farmers applied all required crop management practices to produce the species (land cleaning before establishment, pegging and lining, holing, base manure application, crop irrigation, weeding, pruning, fertilizers application, and pests and diseases control). Farmers were grouped into three clusters based on crop management practices. There was a strong and highly significant agreement among farmers (Kendall’s W = 0.8, p < 0.001) that bush fire, poor plant growth, drought, pests, and parasitic weed were the five most important constraints in Southwest Nigeria. In Southeast Nigeria, damage by insects and birds, poor seed germinability and poor knowledge of cultivation technics were the most important constraints challenging production. Farmers’ agreement around these constraints was moderate but highly significant (Kendall’s W = 0.6, p < 0.001). Overall, the top three desired breeding traits by farmers included: high growth rate, extended fruit shelf-life, and high fruits yield while the top three consumer’s preferences included: high miraculin potency (long lasting action of the miraculin), fruit glossiness, and high metabolites content. However, cultural specificities were detected in these preferences with a higher agreement in Yoruba farmers’ preferences compared with their counterparts Igbo. The Igbo consumers showed a higher concordance in their traits’ preferences than the Yoruba consumers. These findings pave the way for an informed cultivar development for the Sisrè berry plant in Nigeria and expand knowledge on end-users’ preferences for the species in West Africa.
An alien parasite in a changing world – Ashworthius sidemi has lost its traditional seasonal dynamics
Authors: Magdálek Jan , Škorpíková Lucie , McFarland Christopher , Vadlejch Jaroslav
Published: November 2023

A non-native nematode Ashworthius sidemi has emerged in captive fallow deer in Central and Eastern Europe over the last decade. Although this parasite has been spreading in the wild outside it’s native distributional range and colonising local European host species since the middle of the last century, limited information has been published on the seasonality of A. sidemi and its susceptibility to anthelmintics. To address this knowledge gap, we conducted a study to investigate seasonal dynamics of the non-native parasite in the current Central European climate conditions. We collected freshly voided faecal pellets at four-week intervals from February 2018 to February 2020 at a fallow deer reserve with a known history of A. sidemi presence. The faecal pellets obtained were pooled after each site visit (n = 25) and coprocultured to obtain the third stage larvae of trichostrongylid nematodes at monthly intervals. Total genomic DNA was extracted from the recovered larvae. Using real-time multiplex PCR, A. sidemi DNA was detected in 17 out of 25 larval samples (68% prevalence). During the monitoring period, the annual administration of ivermectin based premix (Cermix) took place in January 2018, 2019, and 2020, and additionally a mixture of rafoxanide and mebendazole (Rafendazol) was administered once in spring 2019. The probability of parasite presence was significantly influenced by the time since the drug administration (p = 0.048) and the mean temperature at the location (p = 0.013). Larval samples negative for A. sidemi were always identified shortly after the drug administration. However, rapid pasture contamination by the parasite eggs from two to three months after Cermix administration and within one month after Rafendazol administration suggest only a short-lived efficacy of both administered drugs. The abundance of A. sidemi DNA was positively affected by mean temperature (p = 0.044) and remained relatively stable throughout the monitoring period, with the highest peak in August 2018 and 2019. Pasture contamination with A. sidemi eggs occurred almost all year round, with the exception of the beginning of 2018, 2019, and 2020. These findings indicate adaptation of a non-native parasite to the current climatic conditions of the Czech Republic resulted in negligible seasonal patterns of parasite egg shedding.
Characterization of a 3D Printed Endovascular Magnetic Catheter
Authors: Ansari Mohammad Hasan Dad , Ha Xuan Thao , Ourak Mouloud , Borghesan Gianni , Iacovacci Veronica , Vander Poorten Emmanuel , Menciassi Arianna
Published: November 2023

Minimally invasive endovascular procedures rely heavily on catheter devices. However, traditional catheters lack active steering requiring considerable skill on the surgeon’s part to accurately position the tip. While catheter tips could be made steerable using tendon-driven and Pneumatic Artificial Muscle (PAM) approaches, remote magnetic actuation is uniquely suited for this task due to its safety, controllability, and intrinsic miniaturization capabilities. Soft composite magnetic materials feature embedding distributed magnetic microparticles compared with attaching discrete permanent magnets proving beneficial in steerability and control. This work demonstrates the fabrication of a soft hollow magnetic tip that can be attached to a catheter to make the assembly steerable. The catheter tip is extensively characterized in terms of bending hysteresis, bending force, and dynamic response. The catheter showed average hysteresis between 5% and 10% and bending forces up to 0.8 N. It also showed a good dynamic response by changing its bending angle in <200 ms under a step response.
Jet Engine Turbine Mechanical Properties Prediction by Using Progressive Numerical Methods
Authors: Spodniak Miroslav , Hovanec Michal , Korba Peter
Published: November 2023

The propulsion system for an aircraft is one of its most crucial systems; therefore, its reliable work must be ensured during all operational conditions and regimes. Modern materials, techniques and methods are used to ensure this goal; however, there is still room for improvement of this complex system. The proposed manuscript describes a progressive approach for the mechanical properties prediction of the turbine section during jet engine operation using an artificial neural network, and it illustrates its application on a small experimental jet engine. The mechanical properties are predicted based on the measured temperature, pressure and rpm during the jet engine operation, and targets for the artificial neural network are finite element analyses results. The artificial neural network (ANN) is trained using training data from the experimental measurements (temperatures, pressure and rpm) and the results from finite element analyses of the small experimental engine turbine section proposed in the paper. The predicted mechanical stress by ANN achieved high accuracy in comparison to the finite element analyses results, with an error of 1.38% for predicted mechanical stress and correlation coefficients higher than 0.99. Mechanical stress and deformation prediction of the turbine section is a time-consuming process when the finite element method is employed; however, the method with artificial neural network application presented in this paper decreased the solving time significantly. Mechanical structural analyses performed in ANSYS software using finite element modeling take around 30–40 min for one load step. In contrast, the artificial neural network presented in this paper predicts the stress and deformation for one load step in less than 0.00000044 s.
A Multicriteria Model for Estimating Coffea arabica L. Productive Potential Based on the Observation of Landscape Elements
Authors: Cunha Jorge Eduardo F. , Martins George Deroco , Fraga Júnior Eusímio Felisbino , Camboim Silvana P. , Bravo João Vitor M.
Published: November 2023

Understanding a crop’s productive potential is crucial for optimizing resource use in agriculture, encouraging sustainable practices, and effectively planning planting and preservation efforts. Achieving precise and tailored management strategies is equally important. However, this task is particularly challenging in coffee cultivation due to the absence of accurate productivity maps for this crop. In this article, we created a multicriteria model to estimate the productive potential of coffee trees based on the observation of landscape elements that determine environmental fragility (EF). The model input parameters were slope and terrain shape data, slope flow power, and orbital image data (Landsat 8), allowing us to calculate the NDVI vegetation index. We applied the model developed to coffee trees planted in Bambuí, Minas Gerais, Brazil. We used seven plots to which we had access to yield data in a recent historical series. We compared the productivity levels predicted by the EF model and the historical productivity data of the coffee areas for the years 2016, 2018, and 2020. The model showed a high correlation between the calculated potential and the annual productivity. We noticed a strong correlation (R2) in the regression analyses conducted between the predicted productive potential and the actual productivity in 2018 and 2020 (0.91 and 0.93, respectively), although the correlation was somewhat weaker in 2016 (0.85). We conclude that our model could satisfactorily estimate the yearly production potential under a zero-harvest system in the study area.
Research on the Adaptive Cleaning System of a Soybean Combine Harvester
Authors: Liu Peng , Wang Xiangyou , Jin Chengqian
Published: November 2023

This study investigates the adaptive cleaning system of a soybean combine harvester, addressing the issue of low adaptability in matching the cleaning parameters of the air-and-screen cleaning device of domestic combine harvesters to varying soybean extract characteristics. This mismatch results in high cleaning loss and impurity rates during soybean machine harvesting. Through cleaning experiments, we examine the impact on soybean machine harvesting, where the cleaning loss rate accounts for approximately 10.08% of the total loss rate. The weight of the cleaning loss rate is lower than that of the impurity rate. Additionally, we establish a linear relationship between cleaning parameters and the corresponding cleaning loss rate and impurity rate. We design an adaptive control strategy workflow chart and integrate the adaptive cleaning system into the soybean combine harvester. Verification tests confirm the effectiveness of the adaptive control function. Comparative analysis reveals a reduction of 0.19% in cleaning loss rate and 0.98% in impurity rate compared to the air-and-screen cleaning device. The adaptive cleaning system significantly improves cleaning quality during soybean machine harvesting and enhances the intelligent capabilities of the air-and-screen cleaning device. The results provide practical insights and theoretical guidance for the development of high-quality, low-loss cleaning technology in soybean machine harvesting in China.
Swing Regulates Movement Direction in the Sea Cucumber Apostichopus japonicus in the Presence of Food Cue: New Insights into Movement Patterns
Authors: Zhao Zihe , Sun Jiangnan , Yu Yushi , Ding Peng , Ding Jun , Chang Yaqing , Zhao Chong
Published: November 2023

Regulating movement direction is essential in the locomotion of animals. Sea cucumbers, as eyeless animals, do not have eyes for the perception of the surrounding environment and food. They have a unique way of swinging their bodies when a food cue is detected, although they lack an important perceptual tool. The present study investigated the movement patterns of the sea cucumber Apostichopus japonicus in the absence of a food cue (experiment 1) and in the presence of a food cue (experiment 2). In experiment 1, we found that the movement of sea cucumbers was close to a linear motion (motion linearity 0.91 ± 0.01). In experiment 2, sea cucumbers most frequently adjusted the movement direction when being exposed to food (84 times/216 min), indicating that sea cucumbers adjusted the direction of movement in the swing state but not the motion state. In experiment 2, we found significantly lower time in the immobility state in the sea cucumbers in the presence of food cues compared to that of those without being exposed to food cues, and the frequency of the motion state in response to food cues was 1.6 times than that of those without food cue. This suggests that food cues cause the change in motion state in sea cucumbers. Swing frequency was 1.7 times higher in sea cucumbers exposed to food cues than that of those not exposed to food cues. Further, sea cucumbers in the presence of food showed significantly better performances in swing angle and swing velocity compared to those not exposed to food cues. This suggests that food cue significantly affects the swing state of sea cucumbers. Notably, the present study described the movement patterns of sea cucumbers when they detected food cues, and other factors (such as the detection of predators) need to be further studied. The present study provides new insights into the regulation of movement direction in eyeless organisms.
Quality-of-Life Assessments in Zoo Animals: Not Just for the Aged and Charismatic
Authors: Campbell-Ward Michelle
Published: November 2023

Zoos should aim to provide all of their animals with a good quality of life (QoL) throughout all life stages. In parallel with the evolution of QoL assessment questionnaires and tools in human and domestic animal settings, in recent times, some individual zoos and zoo industry associations have incorporated such instruments into their animal management practices. This has been conducted predominantly to inform, monitor, and document end-of-life decision-making for large, charismatic mammals. There is scope to expand the use of these tools to improve their utility, validity, reliability, and value to an animal welfare program. Assessment of QoL is a complex task given that the notion being measured is abstract and self-determined, and the design and purpose of the tools to do this require careful consideration. This review explores the QoL concept as it applies to animals, the assessment indications and methodologies relevant to a zoo setting, and the importance of considering QoL at any life stage across species. An overview of current thinking and the applications and limitations of QoL evaluation of captive wild animals is offered to promote and aid facility practice reviews and to help direct future innovations that leverage concurrent and converging advances in zoo animal welfare science.
Analysis and Comparison of Proteomics of Placental Proteins from Cows Using Different Proteases
Authors: Shen Liuhong , Zhang Zeru , Zhang Yue , Zhao Yuquan , Fan Lei , Yu Shumin , Cao Suizhong , Huang Yixin
Published: November 2023

Newly found biochemical characteristics of the placenta can provide new insights for further studies on the possible markers of physiological/pathological pregnancy or the function of the placenta. We compared the proteome of the dairy cow placenta after enzymatic hydrolysis by three different proteases using a label-free mass spectrometry approach. In total, 541, 136, and 86 proteins were identified in the trypsin group (TRY), pepsin group (PEP), and papain group (PAP). By comparing the proteome of the PAP and TRY, PEP and TRY, and PEP and PAP groups, 432, 421, and 136 differentially expressed proteins were identified, respectively. We compared the up-regulated DEPs and down-regulated DEPs of each comparison group. The results show that the proteins identified by papain were mostly derived from the extracellular matrix and collagen, and were enriched in the relaxin signaling pathway and AGE-RAGE signaling pathway in diabetic complications; pepsin digestion was able to identify more muscle-related proteins, which were enriched in the lysosome, platelet activation, cardiac muscle contraction, the bacterial invasion of epithelial cells, and small cell lung cancer; trypsin mainly enzymatically degraded the extracellular matrix, blood particles, and cell-surface proteins that were enriched in arginine and proline metabolism, olfactory transduction proteasome, protein processing in the endoplasmic reticulum, pyruvate metabolism, and arrhythmogenic right ventricular cardiomyopathy (ARVC). In summary, these results provide insights into the discovery of the physiological functions of dairy cow placenta and the selection of proteases in dairy cow placenta proteomics.
Neonatal–Maternal Bodyweight Ratio at Birth: An Indicator for First-Week Survival Prognosis in Canine Newborns
Authors: Alonge Salvatore , Beccaglia Michela , Trovò Chiara , Melandri Monica , Migliaretti Giuseppe
Published: November 2023

Objectives. In dogs, neonatal bodyweight (NBW) varies at birth. Size-specific reference values for NBW are essential to correctly manage newborns. The present study aimed to define a new tool to evaluate NBW that could be routinely applied in canine neonatology, promptly identifying puppies requiring more care. Methods. The records of 89 litters were retrospectively evaluated. Data were grouped according to maternal bodyweight (MBW) in five categories: toy (≤5 kg), small (5.1–9.9 kg), medium (10–24.9 kg), large (25–39.9 kg), and giant (≥40 kg) dogs. At birth, the NBW of 412 puppies, alongside their litter size (LS) and gender (G), were recorded. Neonatal mortality within the first week was considered. The influence of MBW, LS, and G on NBW and the effect of NBW on the 1-week outcome were evaluated using ANOVA (p < 0.05). The ratio between NBW and MBW expressed as a percentage (N-MBW%), was assessed for each puppy. Through Receiver-Operating Characteristic (ROC) curves, N-MBW% thresholds between puppies alive or dead at one week of age were calculated in each group. Results. The LS was different among groups, except for small vs. medium dogs. In small litters, N-MBW% was lower in medium-, large- and giant-sized dogs than in toy and small dogs. In medium and large litters, N-MBW% differed among the five groups. Male and female N-MBW% differed among the five groups. Only in large and giant sizes did LS affect N-MBW%, which was lower in a large LS. The N-MBW% was higher in healthy puppies than in those who died within one week. The ROC-derived N-MBW% thresholds were as follows: 4.5% in toy-, 3.2% in small-, 1.5% in medium-, 1.2% in large-, and 1% in giant dogs. Clinical significance. The ROC-derived N-MBW% thresholds can be used to cautiously identify puppies at increased risk for one-week mortality and may be helpful in clinical practice, representing a suitable parameter to give a prognosis on 1-week survival immediately at birth.
New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines
Authors: Orabi Mohamed A. A. , Orabi Esam A. , Awadh Ahmed Abdullah Al , Alshahrani Mohammed Merae , Abdel-Wahab Basel A. , Sakagami Hiroshi , Hatano Tsutomu
Published: November 2023

Polyphenols have a variety of phenolic hydroxyl and carbonyl functionalities that enable them to scavenge many oxidants, thereby preserving the human redox balance and preventing a number of oxidative stress-related chronic degenerative diseases. In our ongoing investigation of polyphenol-rich plants in search of novel molecules, we resumed the investigation of Lawsonia inermis L. (Lythraceae) or henna, a popular ancient plant with aesthetic and therapeutic benefits. The leaves’ 70% aq acetone extract was fractionated on a Diaion HP-20 column with different ratios of H2O/an organic solvent. Multistep gel chromatographic fractionation and HPLC purification of the Diaion 75% aq MeOH and MeOH fractions led to a new compound (1) along with tannin-related metabolites, benzoic acid (2), benzyl 6′-O-galloyl-β-D-glucopyranoside (3), and ellagic acid (4), which are first isolated from henna. Repeating the procedures on the Diaion 50% aq MeOH eluate led to the first-time isolation of two O-glucosidic ellagitannins, heterophylliin A (5), and gemin D (6), in addition to four known C-glycosidic ellagitannins, lythracin D (7), pedunculagin (8), flosin B (9), and lagerstroemin (10). The compound structures were determined through intensive spectroscopic investigations, including HRESIMS, 1D (1H and 13C) and 2D (1H–1H COSY, HSQC, HMBC, and NOESY) NMR, UV, [α]D, and CD experiments. The new structure of 1 was determined to be a megastigmane glucoside gallate; its biosynthesis from gallic acid and a β-ionone, a degradative product of the common metabolite β-carotin, was highlighted. Cytotoxicity investigations of the abundant ellagitannins revealed that lythracin D2 (7) and pedunculagin (8) are obviously more cytotoxic (tumor specificity = 2.3 and 2.8, respectively) toward oral squamous cell carcinoma cell lines (HSC-2, HSC-4, and Ca9-22) than normal human oral cells (HGF, HPC, and HPLF). In summary, Lawsonia inermis is a rich source of anti-oral cancer ellagitannins. Also, the several discovered polyphenolics highlighted here emphasize the numerous biological benefits of henna and encourage further clinical studies to profit from their antioxidant properties against oxidative stress-related disorders.
Low-Frequency Air–Bone Gap and Pulsatile Tinnitus Due to a Dural Arteriovenous Fistula: Considerations upon Possible Pathomechanisms and Literature Review
Authors: Tozzi Andrea , Castellucci Andrea , Ferrulli Giuseppe , Martellucci Salvatore , Malara Pasquale , Brandolini Cristina , Armato Enrico , Ghidini Angelo
Published: November 2023

Low-frequency air–bone gap (ABG) associated with pulsatile tinnitus (PT) and normal impedance audiometry represents a common finding in patients with third window syndromes. Other inner disorders, including Meniere’s disease (MD), perilymphatic fistula and intralabyrinthine schwannoma, might sometimes result in a similar scenario. On the other hand, PT is frequently associated with dural arteriovenous fistula (DAVF), while conductive hearing loss (CHL) is extremely rare in this clinical setting. A 47-year-old patient was referred to our center with progressive left-sided PT alongside ipsilateral fullness and hearing loss. She also experienced headache and dizziness. Otoscopy and video-oculographic examination were unremarkable. Conversely, a detailed instrumental audio-vestibular assessment revealed low-frequency CHL with normal impedance audiometry, slight left-sided caloric weakness, slightly impaired vestibular-evoked myogenic potentials on the left and normal results on the video-head impulse test, consistent with an MD-like instrumental profile. Gadolinium-enhanced brain MRI revealed an early enhancement of the left transverse sinus, consistent with a left DAVF between the left occipital artery and the transverse sinus, which was then confirmed by angiography. A trans-arterial embolization with Onyx glue was performed, resulting in a complete recession of the symptoms. Post-operatively, the low-frequency ABG disappeared, supporting the possible role of venous intracranial hypertension and abnormal pressure of inner ear fluids in the onset of symptoms and offering new insights into the pathomechanism of inner ear CHL.
Prediction of Spasticity through Upper Limb Active Range of Motion in Stroke Survivors: A Generalized Estimating Equation Model
Authors: Adeel Muhammad , Peng Chih-Wei , Lee I-Jung , Lin Bor-Shing
Published: November 2023

Background: We aim to study the association between spasticity and active range of motion (ROM) during four repetitive functional tasks such as cone stacking (CS), fast flexion–extension (FFE), fast ball squeezing (FBS), and slow ball squeezing (SBS), and predicted spasticity models. Methods: An experimental study with control and stroke groups was conducted in a Medical Center. A total of sixty-four participants, including healthy control (n = 22; average age (years) = 54.68 ± 9.63; male/female = 12/10) and chronic stroke survivors (n = 42; average age = 56.83 ± 11.74; male/female = 32/10) were recruited. We employed a previously developed smart glove device mounted with multiple inertial measurement unit (IMU) sensors on the upper limbs of healthy and chronic stroke individuals. The recorded ROMs were used to predict subjective spasticity through generalized estimating equations (GEE) for the affected side. Results: The models have significant (p ≤ 0.05 *) prediction of spasticity for the elbow, thumb, index, middle, ring, and little fingers. Overall, during SBS and FFE activities, the maximum number of upper limb joints attained the greater average ROMs. For large joints, the elbow during CS and the wrist during FFE have the highest average ROMs, but smaller joints and the wrist have covered the highest average ROMs during FFE, FBS, and SBS activities. Conclusions: Thus, it is concluded that CS can be used for spasticity assessment of the elbow, FFE for the wrist, and SBS, FFE, and FBS activities for the thumb and finger joints in chronic stroke survivors.
Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells
Authors: Atiya Huda I. , Gorecki Grace , Garcia Geyon L. , Frisbie Leonard G. , Baruwal Roja , Coffman Lan
Published: November 2023

The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell–cell adhesion and the acquisition of motile and stem-like phenotypes. A critical modulator of EMT in cancer cells is the stromal tumor microenvironment (TME), which can promote the acquisition of a mesenchymal phenotype through direct interaction with cancer cells or changes to the broader microenvironment. In this review, we will explore the role of stromal cells in modulating cancer cell EMT, with particular emphasis on the function of mesenchymal stromal/stem cells (MSCs) through the activation of EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune cell alteration, and metabolic rewiring.
Therapeutic Potential of Antioxidants and Hybrid TEMPOL Derivatives in Ocular Neurodegenerative Diseases: A Glimpse into the Future
Authors: Amankwa Charles E. , Kodati Bindu , Donkor Nina , Acharya Suchismita
Published: November 2023

Reactive oxygen species play a significant role in the pathogenesis of various ocular neurodegenerative diseases especially glaucoma, age-related macular degeneration (AMD), and ocular ischemic stroke. Increased oxidative stress and the accumulation of ROS have been implicated in the progression of these diseases. As a result, there has been growing interest in exploring potential therapeutic and prophylactic strategies involving exogenous antioxidants. In recent years, there have been significant advancements in the development of synthetic therapeutic antioxidants for targeting reactive oxygen species (ROS) in neurodegenerative diseases. One area of focus has been the development of hybrid TEMPOL derivatives. In the context of ocular diseases, the application of next-generation hybrid TEMPOL antioxidants may offer new avenues for neuroprotection. By targeting ROS and reducing oxidative stress in the retina and optic nerve, these compounds have the potential to preserve retinal ganglion cells and trabecular meshwork and protect against optic nerve damage, mitigating irreversible blindness associated with these diseases. This review seeks to highlight the potential impact of hybrid TEMPOL antioxidants and their derivatives on ocular neurodegenerative disorders.
Enhancing Semantic Web Technologies Using Lexical Auditing Techniques for Quality Assurance of Biomedical Ontologies
Authors: Burse Rashmi , Bertolotto Michela , McArdle Gavin
Published: November 2023

Semantic web technologies (SWT) represent data in a format that is easier for machines to understand. Validating the knowledge in data graphs created using SWT is critical to ensure that the axioms accurately represent the so-called “real” world. However, data graph validation is a significant challenge in the semantic web domain. The Shapes Constraint Language (SHACL) is the latest W3C standard developed with the goal of validating data-graphs. SHACL (pronounced as shackle) is a relatively new standard and hitherto has predominantly been employed to validate generic data graphs like WikiData and DBPedia. In generic data graphs, the name of a class does not affect the shape of a class, but this is not the case with biomedical ontology data graphs. The shapes of classes in biomedical ontology data graphs are highly influenced by the names of the classes, and the SHACL shape creation methods developed for generic data graphs fail to consider this characteristic difference. Thus, the existing SHACL shape creation methods do not perform well for domain-specific biomedical ontology data graphs. Maintaining the quality of biomedical ontology data graphs is crucial to ensure accurate analysis in safety-critical applications like Electronic Health Record (EHR) systems referencing such data graphs. Thus, in this work, we present a novel method to create enhanced SHACL shapes that consider the aforementioned characteristic difference to better validate biomedical ontology data graphs. We leverage the knowledge available from lexical auditing techniques for biomedical ontologies and incorporate this knowledge to create smart SHACL shapes. We also create SHACL shapes (baseline SHACL graph) without incorporating the lexical knowledge of the class names, as is performed by existing methods, and compare the performance of our enhanced SHACL shapes with the baseline SHACL shapes. The results demonstrate that the enhanced SHACL shapes augmented with lexical knowledge of the class names identified 176 violations which the baseline SHACL shapes, void of this lexical knowledge, failed to detect. Thus, the enhanced SHACL shapes presented in this work significantly improve the validation performance of biomedical ontology data graphs, thereby reducing the errors present in such data graphs and ensuring safe use in the life-critical applications referencing them.
Quantitative Galactose Colorimetric Competitive Assay Based on Galactose Dehydrogenase and Plasmonic Gold Nanostars
Authors: Munyayi Tozivepi Aaron , Mulder Danielle Wingrove , Conradie Engela Helena , Johannes Smit Frans , Vorster Barend Christiaan
Published: November 2023

We describe a competitive colorimetric assay that enables rapid and sensitive detection of galactose and reduced nicotinamide adenine dinucleotide (NADH) via colorimetric readouts and demonstrate its usefulness for monitoring NAD+-driven enzymatic reactions. We present a sensitive plasmonic sensing approach for assessing galactose concentration and the presence of NADH using galactose dehydrogenase-immobilized gold nanostars (AuNS-PVP-GalDH). The AuNS-PVP-GalDH assay remains turquoise blue in the absence of galactose and NADH; however, as galactose and NADH concentrations grow, the reaction well color changes to a characteristic red color in the presence of an alkaline environment and a metal ion catalyst (detection solution). As a result, when galactose is sensed in the presence of H2O2, the colored response of the AuNS-PVP-GalDH assay transforms from turquoise blue to light pink, and then to wine red in a concentration-dependent manner discernible to the human eye. This competitive AuNS-PVP-GalDH assay could be a viable analytical tool for rapid and convenient galactose quantification in resource-limited areas.
Design Decision-Making for Construction Waste Minimisation: A Systematic Literature Review
Authors: Mahinkanda Mahinkanda Magalage Madhavee Pradeepika , Ochoa Paniagua Jose Jorge , Rameezdeen Rameez , Chileshe Nicholas , Gu Ning
Published: November 2023

The escalating pace of construction activities has triggered a concerning surge in waste accumulation, underscoring the urgent need for the construction industry to prioritise environmental sustainability and resource conservation. Research indicates that construction waste (CW) from a typical building project can comprise a substantial 30% of the total weight of materials transported to the site. Significantly, one-third of this waste could be avoided through judicious decision-making in the design phase. While waste management during construction has gained substantial attention in the existing literature, the domain of decision-making in the design stage remains relatively unexplored. This study addresses this gap by conducting a systematic literature review (SLR) of 59 articles from 2011 to 2022. The findings emphasise the crucial role of informed decision-making processes in minimising CW during building projects. A conceptual framework emerges from the analysis, highlighting the necessity of establishing a foundation for design decision-making to tackle CW issues effectively. Collaborative networks among stakeholders and an enhanced supply chain, bolstered by robust information sharing, are identified as pivotal factors in improving CW minimisation efforts. Consequently, this study advocates for further research to expand the knowledge base in this vital area, underscoring the imperative for collective efforts in advancing sustainable practices within the construction industry.
Dynamic Response and Optimal Design of Radio Telescope Structure under Wind Load Excitation
Authors: Wang Dawei , Zhang Lei , Yang Fengfu , Yang Jinrong , Wu Yang , Cao Peng
Published: November 2023

The dynamic response of a radio telescope structure under wind load excitation significantly impacts the accuracy of signal reception. To address this issue, this study established a parametric finite element model of a radio telescope to simulate its dynamic response under wind load excitation. An improved Latin hypercube sampling method was applied in the design of experiments (DOEs) to optimize the structural dimensional parameters of various components of the radio telescope with the aim of reducing the dynamic response to wind load. A response surface model and multi-objective genetic algorithm (MOGA) were employed for multi-objective structural optimization of the radio telescope structure. The findings reveal that the thickness of the stiffening ribs, the length of the side of the square hollow pole, the thickness of the middle pole, and the inner diameter of the thin pole are the most influential structural parameters affecting the first-order frequency (F1), second-order frequency (F2), maximum deformation in the x-direction (DX), and maximum deformation in the z-direction (DZ) of the radio telescope, respectively. Optimizing the radio telescope results in a 40.00% improvement in F1 and a 24.16% enhancement in F2, while reducing DX by 43.94% and DZ by 64.25%. The study outcomes offer a comprehensive scheme for optimizing the structural dimensional parameters of various radio telescope components in regions characterized by multiple wind fields.
Policy Mapping for Net-Zero-Carbon Buildings: Insights from Leading Countries
Authors: Le An , Rodrigo Navodana , Domingo Niluka , Senaratne Sepani
Published: November 2023

The construction industry is a key contributor to greenhouse gas emissions, with buildings alone accounting for 39% of the global energy-related carbon emissions. Global carbon emissions from building operations increased by 5% in 2021 compared to 2020. However, the United Nations signed the Paris Climate Agreement in 2015 with global leaders, setting a limit to temperature increases below 2.0 °C or 1.5 °C. To achieve this goal, countries have established net-zero targets to reach carbon neutrality by mid-century. However, while some countries are making significant progress, others lag behind. Therefore, this study focuses on evaluating the actions taken by countries toward carbon neutrality, and on developing a policy roadmap for the construction industry to meet the net-zero-carbon commitments. This research adopted a systematic document review, including document analysis. The evaluation of countries’ practices towards achieving net-zero targets reveals both similarities and differences. The policy maps developed can be customised for decarbonising a country’s overall construction industry and building sector. This study provides insights for research, practice, and society, emphasising the importance of achieving net-zero targets through the implementation of policies, roadmaps, plans, and strategies.
The Influence of Bedroom CO2 Concentration on Sleep Quality
Authors: Wang Rui , Li Wei , Gao Jianfeng , Zhao Chaoyi , Zhang Jiazheng , Bie Qingfeng , Zhang Mingjie , Chen Xinchang
Published: November 2023

A person spends about a third of their life sleeping, and high sleep quality is very important for health. Environmental factors are one of the most important factors affecting sleep quality, and indoor carbon dioxide (CO2) concentration while sleeping has a significant effect on sleep quality. In an indoor bedroom with no open windows and no fresh air system, different numbers of people sleeping will lead to changes in indoor CO2 concentration. In order to study the changes in sleep quality caused by differences in CO2 concentration, experimental research was performed. Objective sleep quality data are collected with polysomnography (PSG) and a subjective questionnaire. The sleep quality of the subjects is tested under three different CO2 concentration levels; the average carbon dioxide concentration of three conditions is 680, 920, and 1350 ppm, which simulate a room with 1, 2, and 3 people sleeping, respectively. Other environment parameters are controlled as follows: test environment temperature is 26 ± 0.5 °C, relative humidity is 50 ± 5%, there is no obvious heat source in the test room, and the radiation temperature and air temperature difference is less than 1 °C. A total of 30 subjective tests were carried out with 10 subjects; the test lasted more than one month. The data subsequently underwent statistical analysis to determine the influence of CO2 concentration on sleep quality. The results show that as the CO2 concentration level increased, the sleep quietness and satisfaction of the subjects gradually decreased, the sleep duration gradually decreased, and symptoms such as throat discomfort, dyspnea, dry and itchy skin, difficulty falling asleep, difficulty waking up, congested nose and bad air smell become more obvious. The PSG test results showed that CO2 concentration has a significant impact on the proportion of the N3 period. According to the group of CO2 concentration conditions, the mean of the N3 period proportion under the conditions of one person, two persons, and three persons is 20.4%, 17.3%, and 14.4%, respectively. Finally, there was also an increase in turning over or awakening during sleep, indicating that sleep quality was reduced under higher CO2 concentrations.
Study of the Effect of Adding Nb2O5 on Calcium Titanate-Based Ferroelectric Ceramics
Authors: Zdorovets Maxim V. , Moldabayeva Gulnaz Zh. , Zhumatayeva Inesh Z. , Borgekov Daryn B. , Shakirzyanov Rafael I. , Kozlovskiy Artem L.
Published: November 2023

This paper considers the effect of adding niobium oxide (Nb2O5) to ferroelectric ceramics based on calcium titanate (CaTiO3), and establishes a connection between the observed alterations in strength and dielectric properties and the variation in the Nb2O5 dopant concentration in the ceramics’ composition. The method of mechanochemical solid-phase synthesis was used as the main method for obtaining the ceramics, followed by thermal sintering under specified conditions in order to form a stable phase composition of the ceramics, and to initialize phase transformations in the composition. Based on the assessment of the phase composition of the resulting ceramics, it was determined that a growth in the Nb2O5 dopant concentration beyond 0.10 mol results in the formation of an orthorhombic-phase CaNb2O4 of the Pbcm(57) spatial system, the weight contribution of which grows. A growth in the Nb2O5 additive concentration results in the formation of two-phase ceramics, the formation of which allows for an enhancement in the mechanical strength of ceramics and resistance to external influences. During the study of the dependence of the strength properties on the dopant concentration alteration, a three-stage change in hardness and crack resistance was established, regarding both structural ordering and phase transformations. The measurement of dielectric characteristics showed the direct dependence of dielectric losses and the dielectric constant on the phase composition of ceramics.