bluuebunny/crossref_metadata_2025 huggingface dataset:
Twelve Tips for Utilizing Residency Program Social Media Accounts for Modified Residency Recruitment
Authors: Bhayani Rakhee K. , Fick Laurel , Dillman Dawn , Jardine Dink A. , Oxentenko Amy S. , O'Glasser Avital
Published: August 2020

This article was migrated. The article was marked as recommended. Social media use across the health professions has significantly expanded in recent years. Specific attention has been paid to both the value of social media use in graduate medical education with residency program twitter accounts. More recently, social media has been examined for its role in supporting the rapid expansion of information exchange and connection across digital and virtual platforms during the COVID-19 pandemic. With the ongoing response to the pandemic, the 2020-2021 residency application cycle is anticipated to be a completely virtual interview process. Here, we draw from our collective experiences managing, maturing, and maximizing social media accounts for residency programs and GME to provide practical tips for using social media for the upcoming virtual interview season.
Ligheder og forskelle i nyere teorier om praktikernes erkendelsesgrundlag
Authors: Petersen Karin Anna
Published: August 2020

Artiklen er opbygget omkring forskellige teoretiske positioner om den praktiske erkendelse. Det empiriske afsæt er den kliniske sygepleje og den modsvarende teoretiske uddannelse, sådan som denne konkret materialiserer sig i et moderne samfund, hvor refleksivitet er et manifest krav. Det erkendelsesteoretiske spørgsmål vedrører imidlertid alle praktikere: Hvad er det praktikeren bruger af sig selv, når han udøver sin praksis? Og hvor kommer det fra?
BIRTH WEIGHT, WEIGHT GAIN, AND OBESITY AMONG CHILDREN IN URUGUAY: A PROSPECTIVE STUDY SINCE BIRTH
Authors: Pereyra Isabel , Gómez Andrea , Jaramillo Karina , Ferreira Augusto
Published: August 2020

ABSTRACT Objective: To examine the effect of birth weight and subsequent weight gain on children being overweight and obese in serial assessments of Uruguayan children living at urban areas. Methods: We used secondary data of pediatric anthropometric measurements and health and socioeconomic characteristics of families that were included in a longitudinal and prospective nationally representative survey (“Encuesta de Nutrición, Desarrollo Infantil y Salud”). The associations of conditional weight gain, being overweight and obesity were tested through correlation coefficients. Multivariate binary logistic regression models were performed to calculate the effect of birth weight on childhood obesity and were adjusted for covariates. Results: For macrosomic babies, there was an increase in the prevalence of overweight and obesity in 70% compared with non-macrosomic babies, when we adjusted for sex, exclusive breastfeeding duration, and household income. The correlation between weight gain and the body mass index for age indicated that the greatest (positive) difference in Z score between measurements increased the obesity levels. Conclusions: Our findings suggest that ensuring optimal birth weight and monitoring and controlling posterior weight gain represent the first steps toward primary prevention of childhood obesity.
ADOÇÃO OBRIGATÓRIA DE IFRS, GOVERNANÇA CORPORATIVA E VALOR DA FIRMA
Authors: Sampaio Joelson , Gallucci Humberto , Silva Vinicius Augusto Brunassi , Schiozer Rafael Felipe
Published: August 2020

RESUMO Estudamos se o nível de divulgação contábil e financeiro afeta o valor da firma, focando a adoção do padrão IFRS no Brasil em 2010. Comparamos firmas com pior qualidade contábil ex-ante (no nível regular e nível 1 de governança corporativa) com firmas similares que já adotavam o IFRS antes de se tornar mandatório (Nível 2 e Novo Mercado). Encontramos que a adoção do IFRS tem um impacto positivo de aproximadamente 30 pontos percentuais no Q de Tobin e 26 pontos percentuais na razão entre valor de mercado e valor patrimonial para firmas nos níveis mais baixos de governança, e reduz substancialmente a diferença de valuation entre firmas nos níveis altos e baixos de governança corporativa. Essa redução na diferença de valuation é parcialmente explicada pelo aumento relativo na participação de estrangeiros no capital acionário e na liquidez das ações das firmas nos níveis mais baixos de governança corporativa.
Deliberative Theory and African Philosophy: The Future of Deliberation in Transitional Societies
Authors: Tavernaro-Haidarian Leyla
Published: August 2020

This article invites a conversation about the role of the media and the responsibility of journalists in post-colonial societies in transition to becoming stable democracies. It outlines some of the specific challenges such societies face in cultivating a discursive environment underpinned by complementarity and mutuality. The article introduces the African philosophy of Ubuntu, a normative basis for journalism and deliberative democracy, which exhibits a distinctly non-partisan approach and resolves some of the exigencies of diversely constituted democracies. It argues that, through the lens of Ubuntu, the media can be seen to act both in the public and the national interest. Overall, this article seeks to redefine the role of media from that of gatekeepers and watchdogs of power to that of mediators for the purpose of seeking consensus among members of society as well as between people and government.
Afterword: Does Deliberative Democracy Have a Role in Our Time of Political Crisis?
Authors: Fung Archon
Published: August 2020

Since the first generation of deliberative democratic theory, and the ‘deliberative turn’ in the 1990s, many societies around the world have become more institutionally fragile, multi-dimensionally unjust, and deeply divided. Does deliberative democracy have a constructive role to play in in these more challenging times in politics? As scholars of deliberation widen their ambit to explore broader forms of political communication, interactions between directly deliberative and non-deliberative institutions, and the roles for forms of highly adversarial political action, developments in deliberative democratic theory can help to guide efforts to strengthen our institutions in the short term and create political arrangements that are more just and democratic in the longer term.
The Federal Reserve’s Review of Its Monetary Policy Framework: A Roadmap
Authors: Altig David , Fuhrer Jeff , Giannoni Marc P. , Laubach Thomas
Published: August 2020

In early 2019, the Federal Open Market Committee (FOMC or the Committee) launched a comprehensive review of its monetary policy framework (MPF)—the strategies, tools, and communication practices employed by the Federal Reserve to achieve its congressionally mandated goals of maximum employment and price stability.
Strengthening the FOMC's Framework in View of the Effective Lower Bound and Some Considerations Related to Time-Inconsistent Strategies
Authors: Duarte Fernando , Johannsen Benjamin K. , Melosi Leonardo , Nakata Taisuke
Published: August 2020

We analyze the framework for monetary policy in view of the effective lower bound (ELB). We find that the ELB is likely to bind in most future recessions and propose some ways that theoretical models imply that the framework could be strengthened. We also discuss ways that commitment strategies, which are not part of the framework, may improve economic outcomes. These policies can suffer from a time-inconsistency problem, which we analyze.
Randomized clinical trial: gold standard of experimental designs - importance, advantages, disadvantages and prejudices
Authors: Sharma Neha , Srivastav Adarsh Kumar , Samuel Asir John
Published: August 2020

BACKGROUND: Randomized controlled trial (RCT) is the gold standard of experimental design or clinical trial design. Only by RCT in research, the cause-and-effect relationship between a set of independent and dependent variables could be demonstrated. RCT has added advantages over other experimental designs due to the presence of the control group. The importance of control in health research trials and its advantages to be elaborated. Though various threats to internal validity in health research trials could be minimized by RCT, various biases in RCT and disadvantages add to its discredit. OBJECTIVE: The aim of the present narrative review is to brief the characteristics, advantages, disadvantages, and various biases in RCT. METHODS: This review does not follow the PRISMA statement, as it was a narrative review. Two databases, namely, Medline through PubMed and Scopus, were searched from inception to July 2020 for the information pertaining to RCTs and included in this narrative review. Only English language articles were searched with the keywords, “Randomized controlled trial,” “Randomized clinical trial,” “experimental design,” and “experimental study.” These keywords are linked together by the Boolean words, “AND,” “OR” and “NOT.” Conference proceedings and only abstracts were not considered for the review. RESULTS: RCTs were explained under characteristics, advantages, disadvantages, importance, and advantages of controls in research, the principle of equipoise, RCTs in the pediatric population, RCTs in the geriatric population, threats to internal validity and steps to minimize them and various biases in RCTs. CONCLUSION: The narrative presentation of RCTs under various important topics have been explained in this review.
Confiabilidade intra e interexaminador da algometria para mensurar o limiar da dor em idosos institucionalizados
Authors: Prestes Yandra Alves , Souza Marilene dos Santos , Pereira Mayara Souza , Ervati Rosiane , Campos Hércules Lázaro Morais
Published: August 2020

INTRODUÇÃO: A dor passa ser um fator importante quando se estuda a população idosa, pois apresenta um grande impacto nas atividades diárias, aumentando  as comorbidades e a mortalidade,  transformando-se em um sério problema de saúde pública. OBJETIVOS: Avaliar a confiabilidade das medidas intraexaminador e interexaminador de um algômetro digital em mensurar o limiar da dor no quadril de idosos institucionalizados e frágeis. Materiais e Métodos: A amostra foi de forma intencional de acordo com a capacidade cognitiva dos idosos para responderem às avaliações; dois examinadores realizaram a algometria na região do quadril em 17 idosos residentes de uma instituição de longa permanência. RESULTADOS: Os coeficientes de correlação intraclasse (CCI) demonstraram alta confiabilidade do instrumento intra-examinador -  iguais a 0,877 e muito alta interexaminador - iguais a 0,973. CONCLUSÃO: Há confiabilidade no algômetro digital em mensurar o limiar de dor no quadril em idosos de uma instituição de longa permanência.
Protocolo de exercícios terapêuticos em grupo para pessoas com doença de Alzheimer
Authors: Dias Carolina Quirino , Barros João Antonio de Sousa , Graciani Zodja , Amato Cibelle Albuquerque de la Higuera , Rodrigues Étria , Vianna Denise Loureiro , Fernandes Susi Mary de Souza
Published: August 2020

INTRODUÇÃO: O envelhecimento gera diversas alterações biológicas que dão origens a condições de saúde como a Doença de Alzheimer (DA) que pode prejudicar a funcionalidade dos idosos.OBJETIVO: Verificar o efeito de um programa de exercícios fisioterapêuticos sobre a saúde dos idosos com DA. MÉTODOS: Foi realizado um estudo longitudinal, em idosos com DA frequentadores de um Centro-Dia. Os participantes foram selecionados por meio de características demográficos e condições de saúde. Para análise das variáveis de desfecho foram avaliados pré e pós intervenção com os testes: Timed Up and Go (TUG), Caixa e Blocos, Escala de Berg e Alcance funcional em pé e sentado. Em seguida foram submetidos a um protocolo de intervenção em grupo dividido em três fases: fase preparatória, fase ativa e fase de desaquecimento. Utilizou-se para análise estatística o Teste T-Student Pareado e a correlação de Pearson. Foi estabelecido Intervalo de Confiança (IC) e p<0,05. RESULTADOS: Foram realizadas 28 sessões com 11 idosas, com idade média de 88 (± 4) anos, frequência semanal no Centro Dia de 4 (± 1) vezes e pontuação média no MEEM de 12 (± 5). Obtiveram significância estatística no teste Alcance Sentado pré 22,3 (±10,4) e pós 28,2 (±9,0), com p = 0,003 e, no teste de TUG pré 16,9 (±5,8) e pós 2,5 (± 3,9), com p = 0,009. Além disso, o teste Berg e TUG apresentaram correlação negativa, classificada como boa p= 0,020. CONCLUSÃO: O protocolo proposto contribuiu para melhora na saúde funcional observadas no aumento do alcance funcional e da mobilidade das idosas.
HTAPP_Dissociation of human neuroblastoma tumors to a single-cell suspension for single-cell RNA-seq using Papain v1
Authors: Patel Anand , Karlstrom Asa , Gordon Brittney , Stewart Elizabeth , Dyer Michael
Published: August 2020

This protocol was used for the dissociation of fresh pediatric neuroblastoma samples from patient tumors or orthotopic patient derived xenografts. Using this method, we were able to prepare highly viable (>90%) single-cell suspensions compatible with droplet-based single-cell RNA-Seq technology (Slyper et al). For the Human Tumor Atlas Pilot Project (HTAPP), this protocol has been successfully applied to neuroblastoma resections collected from abdominal and paraspinal sites. Description of this protocol and guidance for testing and selecting methods for processing other tumor and sample types can be found in Slyper et al.
Human Kidney, Urinary Tract, and Lung Cell Type Mapping Pipeline for the Human Biomolecular Atlas Program (HuBMAP) v1
Authors: Lake Blue , Duong Elizabeth , H Diep Dinh , Sun Xin , K Peter , Hagood Jim , S Pryhuber Gloria , Jain Sanjay , Zhang [University Of California Kun
Published: August 2020

This document provides an overview of the protocols used by the Human Kidney, Urinary Tract, and Lung Mapping Center (KULMAP) for generation of spatially resolved mulitomic cell type organ maps within HuBMAP. This involves sequencing of the transcriptomes and epigenomes of dissociated single cells in a massively parallel manner, which will then inform on a highly multiplexed RNA in situ imaging method (DART-FISH) for spatial mapping of hundreds of molecular targets in the tissue sections, at a subcellular resolution. These spatial molecular maps will serve as scaffolds for computational registration of cell types and the associated transcriptome/chromatin maps to the tissue space.
Managements for brain tumours cases during the COVID-19 pandemic. A protocol for systematic review and meta-analysis. v1
Authors: A Azab Mohammed , Ghozy Sherief , Alomari Abdulraheem , Y Azzam Ahmed
Published: August 2020

Background and Objective: The difficulties of neurosurgical brain tumours patients’ management and surgery during the COVID-19 pandemic are enormous and challenging globally. the review will aim to review the managements have done with brain tumours cases during the period of December 2019 to August 2020 amid the COVID-19 pandemic according to the infection status of the patient and the status of the surgery. Methods and Analysis: This protocol follows the guidelines according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Protocol (PRISMA) and registered on the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY). PubMed, Medline, Scopus and Google Scholar databases will be searched from December 2019 to August 2020 for brain tumours, Infection status and status of the surgery. We will perform study selection, data extraction and data analysis. The primary outcome of this systematic review is to follow-up on the management lines that have been done with brain tumours cases during the period of December 2019 to August 2020 amid the COVID-19 pandemic according to the infection status of patients and status of surgery. Ethical Approvals and Dissemination: This systematic review study will not need ethical approvals, because it doesn’t involve human beings. We aim to publish this systematic review in a peer-reviewed journal. Systematic Review Registration: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 19 August 2020 and was last updated on 19 August 2020 (registration number INPLASY202080082).
ELISA for quantification of IL-4 in human serum. v1
Authors: A Justiz-Vaillant Angel
Published: August 2020

Interleukins (IL) are a type of cytokine first thought to be expressed by leukocytes alone but have later been found to be produced by many other body cells. They play essential roles in the activation and differentiation of immune cells, as well as proliferation, maturation, migration, and adhesion. They also have pro-inflammatory and anti-inflammatory properties. The primary function of interleukins is, therefore, to modulate growth, differentiation, and activation during inflammatory and immune responses. Interleukins consist of a large group of proteins that can elicit many reactions in cells and tissues by binding to high-affinity receptors in cell surfaces. [1] The immunoregulatory cytokine IL-41 (also known as meteorin-like protein) is expressed at high levels in the synovium of patients with psoriatic arthritis (PsA).[2] Reference 1. Justiz Vaillant AA, Qurie A. Interleukin. In:StatPearls. Treasure Island (FL): StatPearls Publishing; June 12, 2019. 2.Onuora S. Novel cytokine, IL-41, linked with PsA.Nat Rev Rheumatol. 2019;15(11):636. doi:10.1038/s41584-019-0314-7
Effects of exergames on the balance of older adults with type 2 Diabetes Mellitus: protocol of a randomized clinical trial v1
Authors: Fagundes de Lima Filho Bartolomeu , Nathalia Priscilla Oliveira Silva Bessa not provided , Tatiana Souza Ribeiro not provided , Ramos Vieira Edgar , Juliana Maria Gazzola not provided , Azevedo da Costa Cavalcanti Fabricia
Published: August 2020

INTRODUCTION: Type 2 diabetes mellitus (T2DM) is the most common form of diabetes, and it has significant effects on balance. Exergames are a beneficial strategy to improve body balance in the elderly, acting as a form of physical exercise. This modality has several benefits based on multisensory stimuli and may be used to regain balance. The objective of this study is to investigate the effects of playing exergames on the balance of older adults with T2DM. METHODOLOGY: This is a single-blinded, randomized clinical trial including 34 participants aged 65–79 years with T2DM. Participants will be randomized into a control group or an experimental group (seven-game protocol on Nintendo Wii®). Both groups will complete two 40-min long sessions per week for 12 weeks. Assessments will be conducted at Onofre Lopes University Hospital. The primary outcome will be the balance score (Mini Balance Evaluation System Test). The secondary outcomes will be the cognitive status (Leganès Cognitive Proof), functional performance (Short Physical Performance Battery Test, Two-Minute Stationary Walk Test, Brazilian OARS Multidimensional Functional Assessment Questionnaire), grip strength (Palmar Grip Test), confidence in balance (Activity Specific Balance Confidence Scale), depressive symptoms (Geriatric Depression Scale), and adverse events. The initial assessment will be called T1, the post-intervention assessment will be called T2, and the follow-up assessment will be called T3.The ANCOVA adjustment will be used to assess baseline values. RECORD: Brazilian Registry of Clinical Trials (REBEC), RBR-67y6cz Registered October 14, 2019.
Protocols for "Chromosome-level genome assembly of the humpback puffer, Tetraodon palembangensis" v1
Authors: Zhang Rui , Li Chang , Yu Mengjun , Huang Xiaoyun , Zhang Mengqi , Liu Shanshan , Pan Shanshan , Xue Weizhen , Wang Congyan , Mao Chunyan , Zhang He , Fan Guangyi
Published: August 2020

The humpback puffer,Tetraodon palembangensis, also known as Pao palembangensis, is a species of poisonous freshwater pufferfish mainly distributed in Southeast Asia (Thailand, Laos, Malaysia and Indonesia). Despite interesting biological features, such as its very inactive nature, tetrodotoxin production and body expansion mechanisms, molecular research on the humpback puffer is still rare because of the lack of a high-quality reference genome. Here, we reported a first chromosome-level genome assembly of an adult humpback puffer, of which the genome size is 362 Mb with ~1.78 Mb contig N50 and ~15.8 Mb scaffold N50s. Based on the genome, ~61.5Mb (18.11%) repeat sequences were also identified, and totally 19,925 genes were annotated, 99.20% of which could be predicted with function using protein-coding function databases. Finally, a phylogenetic tree was constructed with single-copy gene families from ten teleost fishes. The humpback puffer genome will be a valuable genomic resource to illustrate possible mechanisms of tetrodotoxin synthesis and tolerance, providing clues for future detailed studies of biological toxins.
Interrogative Statements in Russian and Spanish Sounding Speech (Based on TV Interview Material)
Authors: Abakumova O.V. , Velichkova L.V.
Published: August 2020

This article is devoted to the study of interrogative statements in Russian and Spanish sounding speech. The role of intonation in creating interrogative meaning is considered. The research is based on the analysis of fragments of video recordings of TV interviews. The texts of the video recordings of the sounding quasi-spontaneous Russian and Spanish speech of the participants of the TV interviews were subjected to an auditive analysis. Analysis of the results of the study of the parameters of interrogative statements in Russian and Spanish sounding speech made it possible to conclude that the behaviour of melodic signs on stressed syllables is nationally specific: the peculiarity of Spanish intonation, which clearly contrasts with Russian, consists in the continuing melodic movement on back-stressed syllables. Based on these parameters of interrogative statements, an attempt is made to represent the system at the intonation level for the Russian and Spanish languages. The appeal to the systematic approach in the study of the intonation level allows us to determine the main units of this level - intonemes as sets of differential features for each of the languages that form communicative types of utterances, and draw conclusions about the main differences in intonation systems.
Formal Features of the Structural-Semantic Categories of One-Part Sentences in the Rutul Language
Authors: Makhmudova S.M.
Published: August 2020

While syntax attracts the attention of an increasing number of linguists in the world, syntactic theories are created based on the linguistic material of most natural languages, the syntax of Dagestani languages remains a kind of lacuna, not known even in a simple descriptive plan. One of the most poorly studied Islands in the Dagestani syntax is single - part sentences that have not been analyzed either in terms of composition or in terms of forms of expression. In the existing research on the syntax of Dagestani languages, single-part sentences are either not considered at all, or are considered very superficially. Meanwhile, single-part sentences are a fairly developed constructive class in Dagestani languages. This work contains an attempt to analyze single-part sentences in the Rutulian language, the syntax of which has not been subjected to special research until now.
A Document from Tangut Regarding the Lease of a Bakery
Authors: Du Jianlu
Published: August 2020

The paper is focused on the study of Document Дх-18993 Agreement on a Bakery Lease to Li Chungou and others, drawn as a result of a contest of tenders conducted in the 1st month of the 12th year of the Guangding reign era kept in the Institute of Oriental manuscripts of the RAS. The writer of the paper proves that the document originates from Khara-Khoto and gives the comments on its content.
Deep Learning Model for Spatial Interpolation of Real-Time Seismic Intensity
Authors: Otake Ryota , Kurima Jun , Goto Hiroyuki , Sawada Sumio
Published: August 2020

Spatial distribution of seismic intensity plays an important role in emergency response during and immediately after an earthquake. In this study, we propose a deep learning model to predict the seismic intensity based on only the observation records at the seismic stations in a surrounding area. The deep learning model is trained using the observation records at both the input and target stations, and no geological information is used. Once the model is developed, for example, using the data from a temporal seismic array, the model can spatially interpolate the seismic intensity from the sparse layout of the seismic stations. The model consists of long short-term memory cells, which are well-established neural network components for time series analysis. We used observed seismograms in 1996 through 2019 at the Kyoshin Network (K-NET) and Kiban–Kyoshin Network (KiK-net) stations located in the northeastern part of Japan. In our deep learning model, approximately 85% of validation data is successfully classified into seismic intensity scales, which is better than adopting either the maximum or weighted average of the input data. We also apply the deep learning model to earthquake early warning (EEW). The model can predict the seismic intensity accurately and provides a long warning time. We concluded that our approach is a possible future solution for increasing the accuracy of EEW.
Automatic Detection of Amplitude-Distorted Samples from Clipped Seismic Waveforms
Authors: Wang Shuqin , Zhang Jinhai
Published: August 2020

Seismic waveforms are essential for seismology but are clipped when their actual amplitudes are too high to be faithfully recorded by seismometers. The clipping effects are popular for both big earthquakes and small earthquakes within a short epicentral distance. Here, we illustrate potential risks of direct usage of clipped waveforms by examining the frequency leakage and show the failure of bandpass filtering for different clipping levels; then we summarize two characteristics of clipped records: (1) The temporal gradient is unusually large around the clipped segment compared with the unclipped portions, and (2) the clipped samples cluster into one segment or several if many samples are involved. Next, we propose three criteria for distinguishing clipped samples from the perfect samples based on these two characteristics. Finally, we design a numerical algorithm for automatic detection of clipped samples using constraints on the gradient, amplitude, and gradient-varying range. Numerical experiments show the excellent performance of our algorithm on automatically detecting the clipped samples. Our algorithm seamlessly integrates all necessary constraints for both flat-top type and back-to-zero type and thus can correctly recognize these two types simultaneously; in addition, it is basically data driven and thus can work well without considering seismometer configuration and instrument type, which would be helpful for real-time detection of clipped records without interruption from human operations. As a robust and swift tool of automatic detection on amplitude-clipped samples, our algorithm could identify most typical clipped records and reduce potential risks due to using unrecognizable clipped waveforms; furthermore, it would be helpful for fast detection and possible restoration of clipped waveforms in the presence of huge volumes of data.
Российский поворот на Восток: достижения, проблемы и перспективы
Authors: Торкунов Анатолий , Стрельцов Дмитрий , Колдунова Екатерина
Published: August 2020

Период, прошедший с момента официального провозглашения российского “поворота на Восток”, позволяет сделать предварительные выводы о его характере, достижениях, проблемах и перспективах. В настоящее время можно также отметить качественные отличия этого курса от российской внешней политики на восточном направлении на более ранних этапах. В частности, следует отметить структурно более сложный характер “поворота на Восток”, обусловленный четким выделением нескольких компонентов на стыке внутренней и внешней политики, а также региональных и глобальных измерений российской внешнеполитической стратегии. Первый компонент относится к сфере международного политэкономического взаимодействия и сочетает в себе мотивы поиска дополнительных источников экономического роста, технологий, а после 2014 г. и альтернативных рынков сбыта продукции российского топливно-энергетического комплекса, а также в целом внешнеполитических и внешнеэкономических альтернатив в условиях нарастающих санкций со стороны США и ЕС. Этому способствовал тот факт, что ключевые азиатские партнеры России (Китай, Индия, Республика Корея, страны Юго-Восточной Азии) отказались участвовать в антироссийских санкциях, а участие в них Японии изначально приобрело номинальный характер. Второй компонент может быть обозначен как носящий внутренний политико-институциональный характер. Он связан с попыткой переосмысления парадигмы и модели развития российских регионов Сибири и Дальнего Востока в контексте существенных трансформаций внешней среды и растущей экономической и демографической асимметрии между европейской и азиатской частями России. Третий компонент включает в себя разработку концептуальной рамки Большой Евразии, позволившей бы России сохранить, а в идеале и приумножить ее интеграционный потенциал в качестве одной из ведущих стран в мировой системе за счет институционализации различного рода экономических и политических партнерств в первую очередь со странами Азии. Если трансформации в рамках первой компоненты к настоящему времени являются очевидными и подвергаются качественной и количественной оценке, представленной в статье, контуры изменений в рамках второй и третьей лишь намечены и требуют серьезной дальнейшей проработки.
OPTIMALISASI POTENSI KARYA MAHASISWA MATA KULIAH GRAFIKA DKV MELALUI GALERI ONLINE
Authors: Sulaiman Annas Marzuki , Sugiyanto Sugiyanto
Published: August 2020

Graphic reproduction courses or printing methods are one of the courses that always exist in every college of Visual Communication Design in Indonesia, with this course students are expected to understand how the Final Artwork (FA) printing process is correct, the result is the quality of the design work Finally, students have met print-ready standards in accordance with the graphic industry standard so that it has the potential to be offered to the public at large as ready-to-use works, but unfortunately the student's work has only ended up in storage. This study aims to optimize the potential that exists in the final design work to be more widely useful. This study uses a qualitative method with a descriptive approach aimed at analyzing the quality of student design assignments in the Gafika Reproduction Method course, and creating an online gallery as a means of channeling existing design potential
E-Assessment on Student's Self-Concept for Physics Learning
Authors: Astalini Astalini , Darmaji Darmaji , Kurniawan Dwi Agus , Anggraini Lika , Perdana Rahmat
Published: August 2020

This study aims to apply students' self-concept E-assessment to SESKA-based physics. Student self-concept E-assessment in this study aims to see students 'self-concept of physics and how the teacher responds to the development of students' self-concept E-assessment with SESKA systems. The method implemented in this research has three stages, namely: (1) Development, (2) Implementation, & (Evaluation). This research was carried out on 450 students and 15 teachers in the Jambi Province of Indonesia. The results of this study indicate students' self-concept of physics is classified as good 47.1% (212 students), and the teacher's response is classified as positive, with 66.7% (10 teachers). Therefore, SESKA-based E-Assessments receives a good response and needs to be developed on a large scale.
E-Module of Cost Estimating Course in Building Construction Vocational Undergraduate Program Faculty of Engineering Universitas Negeri Jakarta
Authors: Arthur Riyan , Dwi Riza Nur , Lenggogeni Lenggogeni
Published: August 2020

This R&D aims to develop e-modules based on blended learning in the cost esti-mating course. The research used the R&D method with the 4D (four-D) model carried out through four main stages, namely define, design, development, and dissemination. The e-module development was limited only to the assessment and limited dissemination to experts or the development stage. This study used a questionnaire as a tool to test the feasibility of the instructional through expert validation and student assessment. The results obtained from Instructional experts, material, and students showed that this electronic module is suitable for use in cost estimating subject in Building Construction Vocational Undergraduate Program, Faculty of Engineering, Universitas Negeri Jakarta. However, further research is needed on the fourth stage (disseminate).
Vepris nobilis plant: a potential source of anticancer agents
Authors: Chepkirui Carolyne , Kagia Richard
Published: August 2020

Background: Cancer is one of the major causes of death worldwide. Current cancer therapy is costly, it has poor therapeutic outcomes and many side effects. Therefore, new medications are needed. Plants have been used as sources of anticancer drugs. Vepris species have anticancer properties. The purpose of this study is to assess Vepris nobilis, a plant found in Kenya as a potential source of anticancer drugs.Methods: The dichloromethane/methanol (CH2Cl2/MeOH) 1:1 extract of the stem bark of Vepris nobilis led to the isolation of an alkaloid named, 4,6-dimethoxy-7-((3-methylbuta-1,3-dien-1-yl)oxy)furo[2,3-b]quinolone. SwissADME online tool was used to assess the compound’s pharmacokinetic parameters. Pass online tool identified potential targets while protox server described the toxicity of the compound. Chimera and Avogadro softwares were used for molecular docking studies.Results: In-silico pharmacokinetic studies, showed that the isolated compound complied with Lipinski rule of five, it showed high gastrointestinal activity, and it also inhibits cytochrome P450 (CYP) isoforms 1A2, 2C9 and 2C19. In toxicity studies the compound was relatively safe with a predicted median lethal dose (LD50) of 1600 mg/kg, apart from potential immunotoxicity and mutagenicity. Molecular docking studies demonstrated that, the compound has potential anticancer activity, it interacted with deoxyribonucleic acid (DNA) topoisomerase I in an almost similar manner to camptothecin though it had less binding potential.Conclusions: 4,6-dimethoxy-7-((3-methylbuta-1,3-dien-1-yl)oxy) furo[2,3-b]quinolone derived from Vepris nobilis is a potential drug for the management of cancer which can be administered orally.
Takayasu arteritis: a comprehensive review of literature
Authors: Bishnoi Ravin K. , Devi Shivani , Rai Shivani , . Gunjot
Published: August 2020

Takayasu arteritis is an inflammatory pulseless disease of large arteries with unknown etiology which advances in three stages i.e. early systemic, vascular, and burnout stage. It is more prevalent in Asian women of childbearing age. Hypertension, fever, weight loss, arthralgia, limb claudication, light-headedness, and arterial pain are common manifestations. Angiography is a gold standard test to evaluate TA. There is no reliable serological marker has been identified. Control on the inflammatory process and hypertension are two imperative angles to treat the disease. Steroids are most used. Reconstructive surgeries are limited to severe and stenotic lesions. This review aims to report comprehensive evidence about Takayasu arteritis. We conducted an integrative review of theoretical and empirical publications reporting epidemiology, etiopathogenesis, classification, diagnostic evaluation, and management of TA. The authors searched PubMed, Embase, and Scopus until March 2020.  A total of 1104 records found, we included 37 papers for review after reading the articles. Remaining was excluded because of no innovative content, insufficient details, and no clear endpoints. This review of the literature presents comprehensive evidence in all fields of TA. Still, large areas need to be studied for better management of patients with TA.
Human rhinosporidiosis: still an elusive disease
Authors: Swain Santosh Kumar
Published: August 2020

Rhinosporidiosis is a granulomatous infection of the mucous membrane caused by Rhinosporidium seeberi. It usually affects the nasal and nasopharyngeal mucosa but sometimes involve extra-nasal sites such as lips, buccal mucosa, palate, larynx, trachea, lacrimal sac, skin, scalp, penis, urethra, vulva and bone. The natural habitat of this organism is water and the infection probably spreads via trans-epithelial penetration. Histopathological examination confirms the diagnosis. The treatment of choice is complete surgical excision with cauterization of the base but the medical treatment shows limited efficacy. The patient of disseminated rhinosporidosis does not respond to the conventional treatment such as surgical excision and dapsone and with amphotericin B also proved futile result. This infection is usually overlooked, despite R. seeberi being endemic in tropical country like India. Due to the negligence in the diagnosis and taxonomic enigma of rhinosporidiosis, here we discuss the details of its epidemiology, etiopathology, clinical presentations, diagnosis and current treatment. Because rhinosporidiosis is relatively rare, we hope this review article will serve as aid and guide to the medical community for helping further research.
Clinical and functional outcome of elastic stable intramedullary nailing in pediatric femoral fractures in the age group of 5-16 years
Authors: Edwin Ajin , I. Ibad Sha , R. Roshna S. , Shah Namitha
Published: August 2020

Background: Fractures of the femur are the most incapacitating fractures. The best treatment for children between five to sixteen years of age is still debated. The ESIN has the benefits of early immediate stability to the involved bone segment, permitting early mobilization and return to the normal activities of the patients, respect for the physes, minimal scarring with lower complications. The purpose of this study was to present this study results following fixation of femoral shaft fractures with titanium elastic nails between the age 5-16 years of age.

Methods: A total 52 patients in the age group of 5-16 years with femoral shaft fractures were stabilized using flexible nailing. Clinical and radiological follow-up was for a minimum period of 24 months. The final results were analysed using Flynn’s criteria.

Results: Mean age at surgery was 7.4 years (range 5.6-14.3 years). The average duration of surgery was 65.3 (45-95) minutes and the mean duration of hospital stay was 8 (5-14) days. Skin irritation due to nail ends was the most common complication followed by significant lengthening (n=6), infection (n=2), significant shortening (n=2), varus angulation (n=2) and delayed union (n=2). The final outcome was excellent in 65.4% cases, satisfactory in 30.8% cases and three patients had poor outcomes as per Flynn's scoring criteria.

Conclusions: In this study, ESIN showed good clinical and radiographic results in the age group 5 to 16 years, with minimal complications and high parent satisfaction consistent with previous studies but lesser number of mid adolescent age groups in the present study is a limitation.
FATORES ASSOCIADOS A SÍNDROME CORONARIANA AGUDA E SUA PREVALÊNCIA ENTRE OS GÊNEROS: REVISÃO INTEGRATIVA
Authors: Assunção Ribeiro Kaiomakx Renato , Martins Soares Thales Antônio , Borges Maria Madalena , Pereira de Abreu Edivalda , Rodrigues dos Santos André , Alves Ferreira Gonçalves Fernanda
Published: August 2020

Objetivo: discutir sore os fatores associados à síndrome coronariana aguda (SCA), bem como sua prevalência entre homens e mulheres. Método: revisão integrativa da literatura, com busca dos artigos nas bases de dados LILACS, SciELO, BDENF, PUBMED, com os artigos publicados entre 2012 e 2018. Resultados: foram encontrados inicialmente 502 artigos, dos quais, 20 compuseram esta pesquisa. O tabagismo foi o fator de risco mais prevalente no surgimento da SCA, seguida da Hipertensão Arterial Sistêmica. Os pacientes acometidos apresentaram como características, 2 ou mais fatores de riscos na ocorrência da SCA. E que o gênero masculino foi o mais acometido por esta patologia. Conclusão: são vários os fatores de riscos para o surgimento da SCA. E que o seu surgimento parece estar associada a presença de 2 ou mais fatores de riscos, o que denota, a necessidade de uma maior ênfase na educação da população sobre a prevenção desses fatores.
Results of the coriander (Сoriandrum sativum L.) study at different sowing date in the conditions of Absheron
Authors: Hasanov H. G. , Mamedova S. А. , Huseynov H. A.
Published: August 2020

Relevance.The article presents the results of studying the economic and biological indicators of various coriander samples planted at the Absheron Experimental Base of the Genetic Resources Institute in the autumn and spring, to select the most promising of them and determine the optimal sowing dates that ensure production for most of the year.

Material and methods. The research material was the seeds of 5 coriander samples (Coriandrum sativum L.) from various early maturity groups introduced on Absheron: Ordubad (cat. No. 31); Iranian (Cat. No. 87); Azerbaijani (cat. No. 157); Dagestan (cat. No. 171); Borchali (cat. No. 167). When carrying out phenological observations, the onset of economic suitability, bolting, flowering and seed maturation was noted. The total yield from the plot was determined.

Results. Phenological observations have shown that depending on the date of coriander samples sowing, the duration of the vegetation period and individual phases of development changed. Sowing dates also significantly affected the early maturity and productivity of the samples, but for different samples to varying degrees. Optimal for the Absheron part of Azerbaijan is the timing of sowing coriander from mid-March to the end of April and in September. The most promising were the coriander samples: Azerbaijan (cat. No. 157), Dagestan (cat. No. 171) and Iranian (cat. No. 87). Sowing at the optimum time of the most productive varieties with a long period of harvest can ensure the uninterrupted supply of fresh coriander greens for most of the year.
Construcción de una escala sobre creencias de docentes de educación media acerca de la reforma de la educación matemática en Costa Rica
Authors: Monge Madriz Carlos A. , Reyes Riotte Natalie , Meza Cascante Luis Gerardo
Published: August 2020

Se presentan los resultados de elaborar y validar una escala tipo Likert para la medición de las creencias de los docentes de la educación media sobre los programas de estudio de matemática aprobados por el Consejo Superior de Educación de Costa Rica en el año 2012, como un componente del proyecto de investigación “Reforma de la educación matemática en Costa Rica. Evaluación de avance a tres años de aplicación y sistemas de creencias de los profesores sobre la reforma” (REMEYC).La versión preliminar de la escala se sometió a un proceso de validación de contenido mediante la técnica de juicio de expertos, con la participación de especialistas en matemática educativa de la Escuela de Matemática del Instituto Tecnológico de Costa Rica. Posteriormente se realizó una prueba piloto con la participación de 51 docentes de matemática de colegios públicos. Con los datos recabados se realizó un estudio de las propiedades psicométricas de la escala, mediante el cálculo del índice de discriminación de los ítems, el análisis de la unidimensionalidad empleando técnicas del análisis factorial y el establecimiento de la confiabilidad aplicando la técnica del alfa de Cronbach. Con base en los resultados del estudio psicométrico se conformó la versión definitiva de la escala integrada por 20 ítems.
Chromatic Perception Mediates the Response to Red, Green, Blue, and Yellow Stimuli among Children from Elementary School in Mexico
Authors: Valera Mota Myrna Miriam , Bernal Hernández Jorge , Ávila Lara Ilhuicamina Melina , Jiménez Valencia Enrique , Guzmán Noriega Mariana
Published: August 2020

Purpose: We evaluated the responses to chromatic perception (wavelength) stimuli in the visible spectrum among children from an elementary school in Nezahualcoyotl Country, Mexico.Materials and Methods: A software developed ad hoc was used to measure how children perceived the colors blue, green, yellow, and red. The tests were in monocular form, and responses were pooled based on their similarity according to the Pearson correlation index and cluster analysis by unweighted averages. A chi-square test was applied to the groups for significant differences. Results: Data from each wavelength were analyzed in relation to age, sex, and ocular laterality. At a wavelength of 450 nm, children aged 6-7 years old (group 1) of both sexes perceived the wavelength as skewed to the left -9.39 nm, while children aged 8- 11 years old (group 2) visualized a leftward skew of -4.40 nm (P 0.0001). Then, at 530 nm, shifts of -5.39 and -6.72 nm were reported in the groups 1 and 2 (P 0.0001), while at 580 nm, the shifts were -2.59 and -2.62 nm for both groups (P 0.0001). Finally, at 710 nm, the shifts were +2.49 and +2.74 nm (P 0.0001). Conclusion: At 450 nm, younger children perceived wavelengths far from normal, but, as they aged, their perceptions normalized. At 530 nm, children perceptions shifted to the left in all cases, getting closer to normality. Finally, at 580 nm, the shift was still leftward but moved to the right at 710 nm in all cases
ANTIFUNGAL ACTIVITIES OF MAULI BANANA STEM AND BASIL LEAVES EXTRACT MIXTURE AGAINST Candida albicans
Authors: Kamalia Nor , Apriasari Maharani Laillyza , Wasiaturrahmah Yusrinie
Published: August 2020

ABSTRACTBackground: Mauli banana stem and basil leaves are natural ingredients that have the potential to be used as a treatment for Candida albicans infections. The methanol extract of mauli banana stem with 25% concentration is merely fungistatic which is still not capable to induce fungicidal effect, while the 100% concentration is known to be less effective than 0.2% chlorhexidine gluconate. Adding basil leaves extract to mauli banana stem extract is expected to increase antifungal activities against Candida albicans. Purpose: to analyze the antifungal activity of mauli banana stem and basil leaves extract mixture with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% against Candida albicans by dilution method. Method: This research used a true experimental method with a pretest–posttest control group design consisting of 11 treatments to obtain Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Result: The 10% concentration was identified as the Minimum Inhibitory Concentration (MIC), and no concentration could be classified as the Minimum Bactericidal Concentration (MBC) because all treatment group still exhibited Candida albicans growth on the SDA medium. Conclusion: Mauli banana stem and basil leaves extract mixture has an MIC value of 10% and does not demonstrate any value for the MBC. Keywords: Basil leaf, Candida albicans, Mauli banana stem, MBC, MIC