bluuebunny/crossref_metadata_2025 huggingface dataset:
Policy Forum: Tax Expenditures—Lessons from the Elimination of Ontario's Tuition and Education Tax Credits
Authors: Neill Christine , Snoddon Tracy
Published: November 2022

Stanley Surrey and others have highlighted tax expenditures as being hidden forms of spending that can evade the type of analysis and scrutiny applied to direct spending programs, allowing inefficient and inequitable programs to persist. But there is only limited empirical evidence on differences in the persistence of similar programs in a tax measure compared to a direct spending form. The conversion of Ontario's education and tuition tax expenditures into a direct form of spending via the existing student aid program provides an interesting case study. As discussed in this article, although the tax credits had never been the subject of a value-for-money audit, the student aid program was reviewed in 2018 shortly after the changeover, to hearty criticism of its distributional effects despite its being less regressive than the tax credit versions. This led to substantial cuts in the program, in line with views on the persistence of tax expenditures.
Planification fiscale personnelle : Aspects fiscaux dont un non-juriste doit tenir compte dans l'examen d'un testament
Authors: McDougall Patricia
Published: November 2022

Le testament est un élément crucial d'un plan successoral. Le conseiller fiscal est souvent amené à examiner le testament d'un client dans le cadre du processus de planification de sa succession. Pour procéder à cet examen en toute confiance et être en mesure de commenter les répercussions fiscales d'un testament, un conseiller fiscal doit connaître les dispositions standard de ce document. Le présent article vise à commenter la structure générale d'un testament standard et les aspects fiscaux dont un conseiller fiscal sans formation juridique doit tenir compte et qu'il doit aborder dans son examen de ce document.
Study On Utilization of Active Natural Zeolite As Ammonia Absorbent In Aquarium As A Medium Fresh Fish Cultivation
Authors: Chairuddin
Published: November 2022

A study of the use of natural zeolite active as ammonia absorbent in an aquarium as the cultivation of medium fresh fish has been conducted. The water sample was taken from the surface water of Toba Lake, Pangururan, Samosir Regency. Natural zeolite was refined until measured at 200 mesh and activated by physics. Determination of ammonia was performed using spectrophotometrically with the Nessler method at the maximum wavelength of 410 nm. The result of the analysis of this study obtained that decrease in water pH and ammonia content in the water after feeding the fish was caused by the absorption of active natural zeolite active to the tenth day which concentration of ammonia on the first and tenth day was 1.2723 mg/L and 2.4171 mg/L with the largest absorption percent on the day to ten was 38.04%.
СИНЕРГІЯ ПУБЛІЧНО-ПРИВАТНОГО ПАРТНЕРСТВА ЯК ЗАПОРУКА ЕФЕКТИВНОГО ФУНКЦІОНУВАННЯ РЕКРЕАЦІЙНО-ТУРИСТИЧНОЇ СФЕРИ У КОНТЕКСТІ СТАЛОГО РОЗВИТКУ РЕГІОНІВ
Authors: Хитра Олена
Published: November 2022

У статті обґрунтована доцільність впровадження до рекреаційно-туристичної сфери проєктів публічно-приватного партнерства (ППП), що символізують об’єднання потенціалів публічного і приватного секторів на засадах синергізму і сталого розвитку регіонів. Розглянуті підходи до тлумачення змісту поняття “публічно-приватне партнерство у рекреаційно-туристичній сфері”, його основні моделі, відмінні риси, ієрархічні рівні та організаційні форми. Проаналізовані базові передумови та очікувані ефекти від впровадження ППП. Публічно-приватне партнерство трактується як “симбіотичний атрактор”, до якого “притягуються” траєкторії розвитку окремих учасників у результаті гармонізації їх ключових інтересів та визнання доцільності кооперації зусиль заради якнайкращого задоволення запитів споживачів туристичних послуг, поліпшення навколишнього середовища і підвищення економічного добробуту суспільства. За результатами дослідження розроблена модель виникнення ефектів синергії в рамках публічно-приватного партнерства у сфері рекреації й туризму.
PELESTARIAN BUDAYA RONDA DAN JIMPITAN DALAM PENINGKATAN SISTEM KEAMANAN LINGKUNGAN DI MANDAN SUKOHARJO
Authors: RIRIS SRI
Published: November 2022

The number of crimes that are currently rife during the Covid-19 pandemic in the Mandan community has made people restless. The patrol activity is seen as an activity that is quite effective in minimizing the crime of theft. However, these activities have begun to be abandoned because of the busyness of the community. This community service provides insight into the importance of preserving the ronda and jimpitan culture in improving the environmental security system. The patrol activity, which is followed by the ‘jimpitan activity, provides the benefits of maintaining environmental security and the results of the pinch can increase cash to support social activities. Social activities that are supported from the results of collecting jimpitan, for example. community service activities, procurement of street lighting lampposts, tirakatan 17's and other activities that are for the common interest.
Uji Kandungan Timbal (Pb) Pada Jajanan Bakso Tusuk Di Sekitar Aur Kuning Secara Spektrofotometri Serapan Atom
Authors: Mega Yulia  , Febriany Helmy , Eka Kusuma Ariya
Published: November 2022

Kota Bukittinggi memiliki lalu lintas yang sangat padat karena berdekatan dengan tempat wisata dan pusat perbelanjaan. Lalu lintas yang padat tersebut meningkatkan resiko makanan yang dijual ditepi jalan terkontaminasi asap kendaraan. Salah satu logam berat yang terkandung pada asap kendaraan adalah timbal yang dapat berbahaya bagi tubuh. Tujuan penelitian ini adalah untuk mengetahui adakah kandungan timbal pada bakso tusuk yang dijual disekitar daerah Aur Kuning. Metoda penelitian ini menggunakan metoda acak sampling dimana sampel diambil sebanyak 5 dari 10 penjual bakso yang ada di sekitar Aur Kuning. Sampel kemudian diujikan secara Spektrofotometer Serapan Atom di Balai Riset Standarisasi Industri Padang. Hasil pemeriksaan didapatkan data bahwa kandungan timbal pada bakso tusuk dari kelima sampel tersebut adalah sampel 2 (0,1741 mg/kg), sampel 3 (0,1288 mg/kg), sampel 4 (0,1815 mg/kg), sampel 5 (0,7651 mg/kg) dan sampel 7 ( 0,1633 mg/kg). Dari hasil tersebut dapat disimpulkan bahwa bakso tusuk yang dijual disekitar Aur Kuning tergolong aman untuk dikonsumsi karena masih berada di bawah batas ketetapan SNI 7387-2009 untuk Bakso (daging dan hasil olahannya) dimana 1,0 mg/kg).
Uji Efektifivitas Ekstrak Etanol Daun Rambutan (Nephelium lappaceum) Sebagai Hemostasis Terhadap Luka Potong Pada Mencit Jantan Galur Swiss-Webster
Authors: Septiani Putri Tria , Rais Khasanah Heti , Irnameria Dira , Farizal Jon , Pudiarifanti Nadia
Published: November 2022

Salah satu tanaman yang dapat digunakan dalam pengobatan tradisional adalah daun rambutan (Nephelium lappaceum). Hasil uji skrining fitokimia menunjukkan bahwa daun rambutan memiliki senyawa berupa alkaloid, flavonoid, tanin dan saponin, dimana flavonoid dan tanin merupakan senyawa utama yang berperan dalam proses hemostasis. Penelitian ini bertujuan untuk mengetahui Efektivitas Ekstrak Etanol Daun Rambutan (Nephelium lappaceum). Metode: Jenis penelitian ini adalah eksperiment laboratorium dengan desain penelitian yaitu Posttest Only Control Group Design. Hasil pengujian menunjukkan adanya perbedaan efek yang bermakna pada ekstrak daun rambutan. Dalam hal ini ekstrak daun bandotan memiliki efek yang paling efektif sebagai hemostatis dan berbeda nyata dengan pemberian povidon iodin sebagai pembanding.  Ekstrak daun rambutan dengan konsentrasi 10% , 20% , dan 40% dapat memberikan efek hemostatis pada mencit. Pemberian ekstrak daun rambutan dengan konsentrasi 40 % memberikan efek hemostatis yang efektif dengan waktu perdarahan yang lebih singkat yaitu 154,92 detik, tetapi efeknya belum seoptimal dengan pemberian povidon iodin sebagai pembanding.
Formulasi Sediaan Pomade Dari Ekstrak Etanol Kemiri (Aleurites moluccana (L) Willd)
Authors: Krisyanella Krisyanella , Atipah Charunisa  , Resva Meinisasti
Published: November 2022

Salah satu yang dapat digunakan sebagai bahan untuk membuat pomade adalah  kemiri (Aleurites moluccana  (L.)  Willd).  Kemiri memiliki  kandungan  zat  bermanfaat  seperti  saponin,  flavonoid, pelifenol dan fitosteron  berkhasiat untuk menyuburkan rambut, menghitamkan rambut secara alami. Berdasarkan hal diatas, maka peneliti tertarik untuk memformulasikan ekstrak etanol kemiri sebagai sediaan pomade. Penelitian ini bertujuan untuk Mengetahui karakteristik formulasi sediaan pomade dengan variasi kosentrasi ekstrak etanol kemiri (Aleurites moluccana (L.) Willd). Metode yang digunakan penelitian bersifat eksperimental untuk meneliti karakteristik sediaan   pomade dengan konsentrasi ekstrak kemiri 5%, 7,5% dan 10% dengan parameter uji organoleptis, homogenitas,daya sebar, pH, kadar abu, freeze-thaw, iritasi dan kesukaan. Hasil uji karakteristik sediaan pomade pada formula I, formula II dan formula III telah memenuhi Karakteristik uji organoleptis, homogenitas, pH, freez-thaw iritasi dan kesukaan. pada hasil uji daya sebar terdapat pada FIII yang memenuhi daya sebar yang baik sedangkan untuk FI, F0, dan FII tidak memenuhi syarat dan kadar abu semua formula diketahui  tidak  memenuhi  syarat.  dari  hasil  penelitian  sediaan  Pomade  Formula  III (kosentrasi 10 %) merupakan karakteristik paling baik. untuk peneliti selanjutnya disaran Melakukan penelitian membuat formulasi Sediaan pomade dengan variasi Basis lain.
Genomics improves risk stratifi cation of adults with T-cell acute lymphoblastic leukemia enrolled in measurable residual disease-oriented trials
Authors: González-Gil Celia , Morgades Mireia , Lopes Thaysa , Fuster-Tormo Francisco , García-Chica Jesús , Zhao Ran , Montesinos Pau , Torrent Anna , Diaz-Beya Marina , Coll Rosa , Hermosín Lourdes , Mercadal Santiago , González-Campos José , Zamora Lurdes , Artola Teresa , Vall-Llovera Ferran , Tormo Mar , Gil-Cortés Cristina , Barba Pere , Novo Andrés , Ribera Jordi , Bernal Teresa , De Ugarriza Paula López , Queipo María-Paz , Martínez-Sánchez Pilar , Giménez Alicia , González-Martínez Teresa , Cladera Antonia , Cervera José , Fernández-Martín Rosa , Ardaiz María Ángeles , Vidal María Jesús , Baena Ángela , López-Bigas Nuria , Bigas Anna , Maciejewski Jaroslaw , Orfao Alberto , Ribera Josep Maria , Genescà Eulalia
Published: November 2022

Genetic information has been crucial to understand the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) at diagnosis and at relapse, but still nowadays has a limited value in a clinical context. Few genetic markers are associated with the outcome of T-ALL patients, independently of measurable residual disease (MRD) status after therapy. In addition, the prognostic relevance of genetic features may be modulated by the specific treatment used. We analyzed the genetic profile of 145 T-ALL patients by targeted deep sequencing. Genomic information was integrated with the clinicalbiological and survival data of a subset of 116 adult patients enrolled in two consecutive MRD-oriented trials of the Spanish PETHEMA (Programa Español de Tratamientos en Hematología) group. Genetic analysis revealed a mutational profile defined by DNMT3A/ N/KRAS/ MSH2/ U2AF1 gene mutations that identified refractory/resistant patients. Mutations in the DMNT3A gene were also found in the non-leukemic cell fraction of patients with T-ALL, revealing a possible mutational-driven clonal hematopoiesis event to prime T-ALL in elderly. The prognostic impact of this adverse genetic profile was independent of MRD status on day +35 of induction therapy. The combined worse-outcome genetic signature and MRD on day +35 allowed risk stratification of T-ALL into standard or high-risk groups with significantly different 5- year overall survival (OS) of 52% (95% confidence interval: 37-67) and 17% (95% confidence interval: 1-33), respectively. These results confirm the relevance of the tumor genetic profile in predicting patient outcome in adult T-ALL and highlight the need for novel gene-targeted chemotherapeutic schedules to improve the OS of poor-prognosis T-ALL patients.
Functional Scheme of the Biomachine System
Authors:   VIM, Chernoivanov V.I. , Tolokonnikov G.K. ,   VIM
Published: November 2022

A functional scheme for biomachine systems is proposed, similar to the typical scheme of a functional system of a behavioral act according to P.K. Anokhin. Such schemes are a certain necessary step towards the formalization and construction of mathematical models for systems, as well as specific practical systems. In the theory of biomachine systems, the proposed functional scheme plays the same role and serves as an easy-to-perceive informal description of the functioning of a biomachine system.
A Study of Serum Creatinine and Urea in Adult Female Individuals and their Correlations with BMI
Authors: Akhter Safina , Sarkar Chandra Rani , Rahim Zahid ATM Zoadur , Ahmed Neaz
Published: November 2022

Background: The World Health Organization has announced overweight and obesity as a global epidemic that has strong associations with renal function impairment.

Objectives: To evaluate the serum creatinine and urea status in adult female individuals with previous normal renal function and to observe the correlation of serum creatinine and urea with body mass index (BMI).

Methods: This cross-sectional analytical study was conducted in the Department of Physiology, Rangpur Medical College, Rangpur. After briefing about the objectives, adult female subjects who met the inclusion and exclusion criteria were enrolled in the study with permission. The study included 90 subjects who were divided into three groups- apparently healthy adult females with normal weight (Group-A), apparently healthy overweight adult females (Group-B), and apparently healthy obese adult females (Group-C). The subjects were selected from different areas of Rangpur city. Their body mass index, serum creatinine, and urea were measured. For statistical analysis, one way ANOVA (post-Hoc) test and Pearson’s correlation coefficient test were performed as applicable by computer-based SPSS-25.0 for windows. Regarding the interpretation of results, p_0.05 was accepted as significant.

Results: The mean serum creatinine level was significantly (p_0.001) higher in overweight and obese female adults than in normal-weight female adults. It was also significantly (p_0.05) higher in obese female adults than in overweight female adults. Again, the mean serum urea level was significantly (p_0.05) higher in overweight female adults than normal-weight female adults and in obese female adults than in overweight female adults. It was also significantly (p_0.001) higher in obese female adults than in normal-weight female adults. This study also found highly significant (p_0.001) positive correlation of serum creatinine (r=0.499) and urea (r=0.396) with body mass index.

Conclusion: Serum creatinine and urea were elevated in overweight and obese female adults and both parameters were positively correlated with BMI. Regular body mass index screening is recommended to assess body weight easily and effectively.

J Rang Med Col. September 2022; Vol. 7, No. 2:25-30
A Comparative Study of the Effect of Body Mass Index on Pregnancy Outcomes in Normal and Overweight Women
Authors: Sarwar Tasnim , Hamid Tamanna
Published: November 2022

Background: Maternal obesity is associated with various antepartum, intrapartum, postpartum, and neonatal complications. Increasing rates of overweight among pregnant women become a significant public health concern with various implications for prenatal care and supervision of delivery.

Objective: The study aimed to determine the adverse maternal and fetal outcomes in primigravid overweight and obese women delivering singleton babies.

Methods: A prospective comparative study was conducted for one year at the Department of Obstetrics and Gynecology, Combined Military Hospital, Rangpur, during the period between July 2019 to June 2020. Primigravid women with a singleton uncomplicated pregnancy with a cephalic presentation at _37 weeks of gestation with accurate information regarding height and weight recorded at the booking visit were included in the study. Comparisons were made between 50 primigravidas with BMI _25 and 50 uncomplicated primigravidas with BMI between 18.5 - 24.99. Statistical analysis was done using SPSS version 16.0. Data were analyzed by the Pearson Chi-square test and Fisher’s exact test.

Results: There was a significant increase in risk of developing gestational hypertension (RR=3.667; CI=1.63-8.27), preeclampsia (RR=7; CI=0.89- 54.83), gestational diabetes (RR=7; CI=0.89-54.83), failed induction of labour (RR=5.50; CI=1.28-23.55), failure to progress (R=6, CI= 1.41-25.44), macrosomia (RR=8, CI=1.04-61.62), NICU admissions (RR=2.45; CI=1.37-4.39), perineal lacerations (RR=7; CI=0.89-54.83), wound infection (RR=8;CI=1.04-61.62) among overweight mothers compared to non-obese mothers.

Conclusions: It is concluded that obesity defined by Asian Indian guidelines (BMI _25 kg/m2) is associated with adverse maternal and fetal outcomes.

J Rang Med Col. September 2022; Vol. 7, No. 2:31-34
Serum Lipid Profiles of Primary Open Angle Glaucoma Patients Treated with Topical Timolol
Authors: Rahman Md Mizanur , Kharul Islam Md Mufakh , Hossain Mohammad Khalid , Mamun Al , Khan Nazneen , Islam Md Shafiqul
Published: November 2022

Background: Primary open-angle glaucoma (POAG) and atherosclerosis both are fairly common diseases among elderly persons, any adverse changes in serum lipids as a result of glaucoma therapy can increase the risk of coronary heart disease many folds. As topical beta blockers are also widely used and often the first line therapy in many patients requiring treatment for glaucoma for a long time, there is also a possible risk that _-blockers such as timolol adversely affect serum lipid profiles.

Objective: The study aimed to evaluate the effect of topical timolol on serum lipid profiles.

Methods: This cross-sectional observational study was performed in the department of ophthalmology, Bangabandhu Sheikh Mujib Medical University With convenience type of sampling technique 40 patients with newly diagnosed cases of primary open-angle glaucoma were selected. Baseline fasting lipid profiles were estimated and then timolol maleate 0.5%, 1 drop 12 hourly in both eyes were prescribed. At follow-up after 4 and 12 weeks, again fasting lipid profiles were estimated of the same patients.

Results: In this study the baseline mean TC, HDL, LDL & TG were 175.4±19.28 , 46.63±5.33, 104.98±18.49,120.48±28.30 (mg/dl±SD) respectively. Baseline TC/HDL was 3.81±0.06. At follow up after 4 weeks there were increased level of TC, LDL,TG, TC/HDL by 0.45% (P=0.822), 0.8% (P=0.807) 1.82%(P=0.375), and 3.14%(P=0.307) respectively and HDL level decreased by 2.68%(P=0.232). At follow-up, after 12 weeks in comparison to baseline lipid levels, there was an increased level of TC, LDL, TG, and TC/HDL by 0.98% (P=0.959), 3% (P=0.996), 2.8% (P=0.104), and 17.0%(P=0.001) respectively and HDL level decreased by 13.61%(P=0.001).

Conclusion: Topical timolol significantly lowers the plasma HDL level. Since the low level of HDL is strongly associated with an increased risk of myocardial infarction, our study cautions against the use of timolol in patients with a previous history of coronary heart disease.

J Rang Med Col. September 2022; Vol. 7, No. 2:40-46
Estimation of Stature from Arm Span: A Prospective Study Among Medical Students of Rangpur Medical College
Authors: Sultana Riada , Anwar Selina , Islam Shamima , Maknunnahar -
Published: November 2022

Background: Arm span is one of the most reliable body parameters for predicting the stature of an individual. It is useful in an age-related loss in stature and in identifying individuals with disproportionate growth abnormalities and skeletal dysplasia.

Objectives: The present study was undertaken to determine whether there is any correlation between stature and arm span and estimate stature from arm span by using multiplication factor and assess the effectiveness of the above estimation by comparing the ‘estimated’ values with the measured values.

Methods: This is a cross-sectional analytical study done in the Department of Anatomy, Rangpur Medical College, Rangpur, from January to December 2018 on purposively selected 700 medical students (350 male and 350 female). Arm span along with their stature was measured directly from the subjects by using an anthropometric technique by a measuring tape. Multiplication factors were estimated for estimating stature and comparison were made between measured and estimated stature using paired “t” test.

Results: The mean normal value of arm span was 170.48±7.38 cm in males and 156.13±5.98 cm in females and the stature was 168.93±0.06 cm in males and 156.23±0.05 cm in females. The multiplication factor was estimated for the same hand measurements with the stature. A significant positive correlation was found in the case of arm span with stature.

Conclusion: Arm span is a valid measure of stature for both adult males and females.

J Rang Med Col. September 2022; Vol. 7, No. 2:47-51
Reconciliation of Ulama and Umara in Socio-Political Conflict through Sufistic Approach
Authors: Ridho Hilmi , Mirwan Mirwan
Published: November 2022

Ulama have a role as cultural and moral figures to protect and foster people in social life. Umara is a political elite tasked with carrying out state political policies and maintaining state ideology. In the socio-political context, the ulama and umara synergize with each other to realize the unity and harmony of the people in religion and the state. In reality, some Islamic organizations led by ulamas create a commotion in the country and are very opposed to the umara policy, causing divisions among community groups. Based on the problems above, the study's results show that  (1) the involvement of ulama and umara in the political stage is not new. That strong support from the Shari'a is exemplified by the Prophet Muhammad and Khulafa Ar-Rashidin. (2) Ulama and umara should create an ideal society, namely a society that is independent and runs on the correct principles. (3) Social Sufism offers a solution to overcome conflicts between ulama and umara amid society.
Online-Offline in Religion; Observing Islamic Learning Patterns in Online Media
Authors: Zuhri Achmad Muhibbin , Alfin Jauharoti
Published: November 2022

This study aims to unravel the phenomenon of digital society in understanding and learning Islam through the internet. The current human tendency to rely on information available through smartphones has given birth to the reality of shifting learning patterns that do not have to meet directly with the teacher. Even the presence of a virtual teacher is considered sufficient to justify an excellent religious way. This study uses a qualitative method with a netnographic approach that intends to reveal social phenomena in cyberspace. This method uses a particular analytical technique offered, AMS (Siber Media Analysis), which goes through 4 levels: Media room level, media document level, media object level, and experience level. This study found that online internet users can access information about religious rituals and procedures for doing them. So, internet users are part of the world's religious adherents who carry out the same religious creed. On the other hand, religious authority as a source of knowledge in learning Islam on the internet is not always institutional but can also be individual. As a result, the Islamic pattern of understanding Islam among netizens is more accessible, inclusive, egalitarian, and shows multidimensional interactions between individuals and other religious groups.
Implementasi Metode Simple Additive Weighting Dalam Penentuan Perawat Terbaik
Authors: Sri Siswanti  , Setiyowati  , Retno Dwi Andari
Published: November 2022

Guna meningkatkan kualitas kinerja perawat, pimpinan Klinik membuat suatu program pemilihan perawat terbaik dengan memberikan reward berupa penambahan gaji bagi perawat terbaik. Program seleksi perawat terbaik ini dilaksanakan setiap akhir tahun. Pada sistem lama proses seleksi saat ini menggunakan satu kriteria yaitu berdasarkan kedisiplinan dan mengabaikan kriteria lain. Hal ini menyebabkan ketidakpuasan bagi para perawat. Untuk mengatasi permasalahan tersebut dibutuhkan suatu sistem pendukung keputusan pemilihan perawat terbaik dengan Metode Simple Additive Weighting (SAW). Tujuan dari Penelitian ini adalah mengembangkan sistem pendukung keputusan untuk pemilihan perawat terbaik dengan menggunakan kriteria kinerja, kedisiplinan, pendidikan, sikap. Menggunakan metode SAW karena metode tersebut mampu menentukan alternative terbaik dan dapat melakukan proses perangkingan. Pengumpulan data melalui wawancara, observasi, dan studi pustaka. Pengembangan sistem menggunakan Model Waterfall, perancangan sistem menggunakan pendekatan terstruktur, bahasa pemrograman dengan PHP, sedangkan untuk pengambilan keputusan menggunakan Metode Simple Additive Weighting. Berdasarkan pengujian sistem baru dengan sistem lama menjukan bahwa sistem baru lebih baik kerena memiliki akurasi 80%.
Sustentabilidade no processo produtivo da indústria cosmética: uma revisão da literatura
Authors: Furman Ana Carolina , Veit Márcia Teresinha , Palácio Soraya Moreno , Gonçalves Gilberto da Cunha , Barbieri Jéssica Caroline Zanette
Published: November 2022

A indústria cosmética é um setor que está sempre em crescimento, a nível mundial e nacional. Nos últimos tempos, o tema sustentabilidade neste setor tem recebido grande interesse dos consumidores, indústrias e organizações de cosméticos. Diante desta percepção, essa revisão sistemática de literatura objetiva explorar a relação entre a sustentabilidade e a indústria de cosméticos e, a possibilidade de substituir matérias-primas convencionais pelas de origem natural e sustentáveis. A coleta de dados foi realizada no período de novembro de 2021 a maio de 2022, nas bases eletrônicas: Scielo, Science Direct, Web of Science, Periódicos CAPES e Google Acadêmico. Para o processo industrial ser considerado sustentável, se destaca a necessidade de avaliar todas as fases do ciclo de vida do produto cosmético, de acordo com os aspectos ambientais, sociais e econômicos. Entretanto, a fase de seleção de matérias-primas é a mais desafiadora, pois deve-se levar em consideração a segurança e a função de cada ingrediente, a estabilidade da formulação, a vida útil do produto e a preferência do consumidor. Há também muitas definições e certificações que acabam deixando o tema confuso e disperso. Sendo assim, alcançar uma produção mais sustentável em relação aos produtos cosméticos é um processo contínuo, que visa muitas mudanças e inovações para desenvolver alternativas seguras e sustentáveis. A partir das informações coletadas com a presente revisão é esperado que as possibilidades de substituições de ingredientes nas formulações cosméticas inspirem maiores esforços colaborativos das comunidades cientificas e das indústrias do setor para se alcançar uma produção mais sustentável.
ANALISIS PENGARUH PELATIHAN DAN KEMAMPUAN KERJA GUNA MENINGKATKAN KINERJA KARYAWAN PT. DEWI SRI KECAMATAN WLINGI KAB. BLITAR
Authors: Damayanti Kristya , Sasmito Aldi
Published: November 2022

Penelitian yang dilakukan di Perkebunan Kopi PT. Dewi Sri bertujuan untuk mengetahui pengaruh pelatihan dan kemampuan kerja terhadap kinerja karyawan. Penelitian ini mengambil responden sebanyak 67 orang. Metode pengumpulan data dilakukan melalui kuesioner / angket, dokumentasi dan wawancara. Teknik analisis data pada penelitian ini adalah analisis deskriptif kuantitatif menggunakan uji validitas, uji reliabilitas, uji asumsi klasik (normalitas, heteroskedastisitas, autokolerasi, multikolinearitas), analisis regresi linier bergada, pengujian hipotesis (uji parsial, uji simultan) dengan bantuan software SPSS. Penelitian ini menggunakan variabel pelatihan dan kemampuan kerja untuk variabel bebas (independen) dan kinerja karyawan untuk variabel terikatnya (dependen). Hasil uji parsial (nilai uji t) menunjukan bahwa variabel independen pelatihan kerja X1 dan kemampuan kerja X2 masing - masing berpengaruh terhadap variabel dependen yaitu kinerja karyawan (Y). Hasil uji simultan (uji F) menunjukan  bahwa variabel independen pelatihan kerja X1 dan kemampuan kerja X2 bersama - sama berpengaruh terhadap variabel dependen yaitu kinerja karyawan (Y).
Aquaculture organic enrichment of marine sediments: assimilative capacity, geochemical indicators, variability, and impact classification
Authors: Cranford PJ , Brager L , Law BA
Published: November 2022

Benthic organic enrichment at 2 high-flow Atlantic salmon Salmo salar farms and at a low-flow mussel Mytilus edulis farm was studied to assess the capacity of local physical and biological processes to assimilate organic waste inputs. Geochemical metrics served as proxies for detecting potential biological effects. High-flow sites are generally predicted to assimilate organic enrichment by flow- and wave-induced waste dispersion and metabolic processes. However, a decrease in porewater dissolved oxygen was detected out to 100 m at the salmon farm with cohesive sediments and to approximately 1000 m outside the farm with permeable sediment. Sediment oxygen consumption was responsive to the vertical flux of organic matter, resulting in hypoxic conditions. An increase in total free sulfides (H2S + HS- + S2-) in porewater was restricted to the immediate vicinity of both salmon farms. Despite exhibiting a high degree of small-scale patchiness, benthic effects were greatest at the fish farms during the pre-harvest period, regardless of season. Natural organic enrichment at the mussel farm constrained the assimilative capacity for biodeposition, resulting in substantial free sulfide accumulation. Sediment free sulfide analysis at a wide array of fish and shellfish farms showed that the ion-selective electrode method that is widely prescribed for regulatory aquaculture monitoring gave biased readings relative to methylene blue colorimetry and direct UV spectrophotometry. The ecological quality status classification system was extended to include quantitative relationships between a wide range of geochemical and biological variables employed worldwide to monitor and regulate the effects of benthic organic enrichment.
A new version of the reconnaissance drought index, N-RDI
Authors: Ghasemi MM , Zarei AR , Mokarram M
Published: November 2022

We present a new, modified version of the reconnaissance drought index (RDI), named the N-RDI. To calculate the N-RDI, precipitation and potential evapotranspiration (PET) were replaced with spatially normalized precipitation and PET. To assess the capability of N-RDI, the RDI and N-RDI were computed at monthly, seasonal, and annual time scales over Iran based on a climatic data series of 12 stations from 1967-2019. Interpolated maps of the RDI, N-RDI, and annual yield of rain-fed winter wheat were then prepared using the inverse distance weighting method. Four regions in Iran (with different climate conditions) were then selected, and 30 random points were chosen in each area. Finally, the capabilities of N-RDI and RDI were compared based on the correlation coefficient (CC) between the difference in the mean rain-fed winter wheat yield (DMRWWY) and the difference in the average RDI (Da-RDI) and the average N-RDI (Da-N-RDI) at selected points, in different regions at different time scales. The CCs were higher between DMRWWY and Da-N-RDI than between DMRWWY and Da-RDI in humid (H) and semi-arid (SA) regions, in H and hyper-arid (HA), in SA and arid (A), in SA and HA, and in A and HA regions in 88.23% of selected periods. Moreover, CCs were greater between DMRWWY and Da-N-RDI than between DMRWWY and Da-RDI in H and A regions in 76.47% of selected periods. The results showed that the capability of the N-RDI for assessing drought in large basins is greater than that of the RDI.
Review of the European Association for the Study of Diabetes (EASD) Annual Meeting
Authors: Fouarge Noemie , Richards Darcy , Meunier-McVey Natasha , Smith Jaki , Hewitt Kirsty
Published: November 2022

AFTER 2 years of virtual meetings, the 58th European Association for the Study of Diabetes (EASD) Annual Meeting took a hybrid form, with 7,716 participants onsite in Stockholm, Sweden, as well as 3,291 participants online. The programme of the congress was developed to cover the most recent developments and breaking news relating to diabetes research, covering the latest innovations and developments in the treatment of Type 1 and Type 2 diabetes (T2D), as well as their complications. Through symposia, debates, prize lectures, oral discussion sessions, and a dedicated e-learning track, a range of topics were discussed.
Tropical Diabetic Hand Syndrome: A Case Report and Literature Review
Authors: Emanah Victor , Ewelukwa Chukwudum , Emehinola Oluwatosin , Asuka Edinen , Oputa-Onwusa Ogochukwu , Olalude Oluwakemi
Published: November 2022

Tropical diabetic hand syndrome (THDS) is an acute complication that mainly affects patients with diabetes living in the tropics. The cause is usually unknown, but it is often preceded by minor trauma to the hand. Other risk factors for TDHS are poor glycaemic control, poorly treated wounds, malnutrition, and diabetic neuropathy. Early signs include swelling and ulceration of the hand. It can rapidly progress to sepsis and may further worsen, leading to deformity, disability, and amputation. If not treated promptly, death may occur. Unlike diabetic foot ulcer, TDHS often goes unreported. Here is a case of a 39-year-old female and a known patient with diabetes who presented to the outpatient department with swelling and tenderness of the left hand, along with foul-smelling purulent discharge. It began after the patient peeled off a patch of scaly, thickened skin over the distal part of their middle finger. Investigations showed high blood sugar and slightly increased leukocyte count. The patient was started on antihyperglycaemic medications and intravenous antibiotics. Urgent surgical debridement was done, which led to amputation of the middle finger. Thereafter, the patient showed significant improvement and was discharged with follow-up instructions. This case report emphasises the importance of timely intervention in cases of tropical diabetic hand syndrome, and the need for adequate patient education on this issue.
Pathophysiology of Gestational Diabetes Mellitus
Authors: Berberoglu Zehra
Published: November 2022

Gestational diabetes mellitus (GDM) is a pregnancy complication defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. The prevalence of GDM is growing rapidly worldwide. Two major metabolic disorders, chronic insulin resistance and β-cell dysfunction, are currently linked to the pathogenesis of GDM, although the cellular mechanisms involved are not yet completely understood. Maternal genetic predisposition coupled with environmental and fetoplacental factors initiates a chain of events that affects mother and fetus, both in the short and long term. Understanding of pathophysiology and risk factors will enhance the possibility of effective screening, early intervention, and even prevention.
The Unconscious with Bond and Lacan: Definition by Deviation
Authors: Holmberg Rafael
Published: November 2022

This article argues that the paradox of James Bond's character (that he accords with the idea he represents precisely by deviating from it) is central to a Lacanian understanding of the unconscious (which is considered as a form of disjunctive synthesis - a logical operation which allows conflicting realities to coexist) This requires a review both of various Bond-moments as well as the role of the Real and Symbolic in the Lacanian unconscious.
PERANCANGAN ANTENA MIKROSTRIP MIMO 2X1 UNTUK FREKUENSI KERJA 2G DAN 5G PADA ACCESS POINT Archer C2
Authors: Hadiwiyatno  , Moh. Abdullah Anshori  , Septriandi Wirayoga
Published: November 2022

Teknologi telekomunikasi pada bidang antena telah mengalami perkembangan. Antena merupakan suatu perangkat yang dapat mengirimkan gelombang elektromagnetik, tergantung penggunaan dan memiliki frekuensi kerja tersendiri. Salah satu jenis antena tersebut ialah antena mikrostrip. Bentuk dan ukuran dimensi antena yang lebih kecil, harga, bahannya yang sederhana serta mampu memberikan kinerja (performance) yang cukup baik. Hal ini merupakan alasan pemilihan antena mikrostrip pada berbagai macam aplikasi. Pemilihan frekuensi kerja pada access point saat ini memiliki variasi 2 macam yaitu 2G dan 5G. Tujuan dari perancangan ini adalah untuk mengetahui pengiriman sinyal yang dihasilkan oleh antena mikrostrip pada alat router dengan spesifikasi 2G 5G dan melakukan analisis kinerja perangkat tersebut khususnya pada bagian antena yang menggunakan bahan dasar FR4. Antena Mikrostrip MIMO 2x1 yang dirancang mampu bekerja pada frekuensi 2G dan 5G, dimana untuk frekuensi untuk 2G adalah 2407.2 MHz dan untuk frekuensi 5G adalah 5820.4 MHz. Untuk bandwith frekuensi 2G memiliki bandwith 84 MHz dan bandwith frekuensi 5G memiliki bandwith 118.4 MHz.
ANALISIS KINERJA GENERATOR INDUKSI 3 FASA BERDASARKAN REGULASI TEGANGANNYA
Authors: Rachmat Sutjipto  , Heri Sungkowo  , Epiwardi Epiwardi
Published: November 2022

Generator induksi 3 fasa bisa digunakan sebagai generator cadangan dari operasi generator sinkron 3 fasa. Generator induksi  3 fasa dapat dibuat dari motor induksi slip ring 3 fasa atau motor sangkar 3 fasa untuk generator induksi SEIG (Self Excited Induction Generator). Motor induksi slip ring 3 fasa berfungsi sebagai generator induksi setelah belitan rotornya disuplai sumber DC dan diputar menggunakan prime mover, sedangkan pada generator SEIG, tegangan listrik dihasilkan dengan bantuan 3 kapasitor yang terhubung delta. Permasalahan yang muncul dalam pengoperasian adalah timbulnya rugi tegangan saat dilaksanakan variasi pembebanan. Untuk menjawab permasalahan tersebut maka diadakan 3 jenis pengetesan (DC Test, Open Circuit Test dan Load Test) pada kedua generator tesebut. Setelah semua percobaan dilaksanakan dan dianalisa maka diketahui bahwa besarnya tegangan output dari generator induksi 3 fasa dipengaruhi oleh besarnya kecepatan generator dan besarnya arus eksitasi. Proses eksitasi dari kedua generator tersebut berbeda, eksitasi dari generator SEIG ditentukan besar dan jenis hubungan kapasitor eksitasi sedangkan generator induksi lainnya ditentukan oleh besarnya tegangan DC yang disuplaikan ke belitan rotor. Tegangan output dari kedua generator induksi juga dipengaruhi oleh besar dan jenis bebannya. Diketahui pula bahwa generator induksi SEIG mempunyai rugi tegangan dan % regulasi tegangan yang lebih besar dikarenakan harga parameter belitannya lebih besar. Untuk menstabilkan tegangan output generator maka dapat dilaksanakan dengan mengatur besarnya arus eksitasi dan kecepatan dari kedua generator induksi tersebut, dengan tetap memperhatikan kemampuan belitan eksitasi dan frekuensi yang dibutuhkan oleh beban serta kesediaan kapasitor untuk generator SEIG.
Integrated analysis of transcriptomics, proteomics and metabolomics data reveals the role of SLC39A1 in renal cell carcinoma
Authors: Yuan Yulin , Liu Zimeng , Li Bohan , Gong Zheng , Piao Chiyuan , Du Yang , Zhan Bo , Zhang Zhe , Dong Xiao
Published: November 2022

Purpose: Accumulating evidence suggests that solute carrier family 39 member 1 (SLC39A1) conceivably function as a tumor suppressor, but the underlying mechanism in renal cell carcinoma (RCC) is poorly understood.

Methods: OSRC-2 renal cancer cells were first transfected with SLC39A1 overexpressed vectors and empty vectors and then used in transcriptomics, proteomics, and metabolomics integrated analyses.

Results: SLC39A1 significantly altered several metabolisms at transcriptional, protein and metabolic levels, including purine and pyrimidine metabolism, amino acids and derivatives metabolism, lactose metabolism, and free fatty acid metabolism. Additionally, SLC39A1 could promote ferroptosis, and triggered significant crosstalk in PI3K-AKT signal pathway, cAMP signal pathway, and peroxisome proliferators-activated receptor (PPAR) signal pathway.

Conclusion: We found SLC39A1 transfection impaired tumor metabolism and perturbed tumor metabolism-related pathways, which was a likely cause of the alteration in cell proliferation, migration, and cell cycle progression in RCC cells. These multi-omics analyses results provided both a macroscopic picture of molecular perturbation by SLC39A1 and novel insights into RCC tumorigenesis and development.
Efficacy and safety of drug-coated balloon combined with cutting balloon for side branch of true coronary bifurcation lesions: Study protocol for a multicenter, prospective, randomized controlled trial
Authors: Wu Haoyu , Deng Jizhao , Liang Lei , Lei Xinjun , Yao Xiaowei , Han Wenqi , Chen Haichao , Shou Xiling
Published: November 2022

Background

Coronary bifurcation lesions are common of percutaneous coronary intervention (PCI), and the optimal interventional therapy strategy is still a matter of debate and remains a challenge for interventional cardiologists. The provisional stenting technique is still a preferred method for most bifurcation lesions, but restenosis of the side branch (SB) occurs in approximately 17–19% of cases. Therefore, the dilemma of reducing SB restenosis still exists, and further research on strategies to reduce restenosis for SB is necessary. Drug-coated balloon (DCB) can reduce clinical events in small vessel disease and in-stent restenosis. The efficacy and safety of DCB for SB of true coronary bifurcation lesions have not been fully investigated. A randomized comparison of DCB combined with cutting balloon angioplasty vs. cutting balloon angioplasty for SB has never been published.

Methods and design

The purpose of this study is to explore the superiority of DCB combined with cutting balloon vs. cutting balloon angioplasty for SB after main vessel (MV) drug-eluting stent implantation of true coronary bifurcation lesions. This study is a multicenter, prospective, randomized controlled trial including 140 patients with true coronary bifurcation lesions. Patients will be randomized in a 1:1 manner to receive either DCB combined with cutting balloon or cutting balloon angioplasty for SB after MV drug-eluting stent implantation. The primary endpoint is the evaluation of late lumen loss (LLL) of SB at the 9-month follow-up. The secondary endpoints include procedural success during initial hospitalization, LLL of MV at the 9-month follow-up, binary angiographic restenosis in MV and SB at the 9-month follow-up, the proportion of patients with a final post-PCI quantitative flow ratio result ≤ 0.80 for SB at the 9-month follow-up, and major adverse cardiac events during the 24-month follow-up.

Conclusions

This clinical trial will provide evidence as to whether DCB combined with cutting balloon for SB of true coronary bifurcation lesions is a superior treatment approach.

Trial Registration Number

ChiCTR2000040475.

Dissemination

The results of this clinical trial will be published in a peer-reviewed journal.
University students' memories of their secondary science education experiences
Authors: Aydin Semih , Kosarenko Nikolay N. , Khlusyanov Oleg V. , Malakhovskaya Vera V. , Kameneva Galina N.
Published: November 2022

Students' attitudes and perceptions about a course of study and their career choices are influenced by their prior educational experiences. These experiences also apply to physics education, which is not exempt from this process. University students' attitudes toward physics classes during their high school years, the teaching methods used in the course, and their opinions about studying physics are investigated in this study. Students majoring in education, engineering, and health sciences at a university in northern Iraq participated in the survey. The survey collected data from 243 students. The researchers designed a survey that was used to collect data. Descriptive statistics, cluster analysis, and the Mann–Whitney and Kruskal–Wallis tests were used to answer the research questions. The results show that students' opinions about high school physics classes can be positive. Students' attitudes and thoughts do not change according to gender, school status, grade level, or departments. The use of technology and supporting course materials were effective in all dimensions.
Factors supporting digital pedagogical competence of primary education teachers in Indonesia
Authors: Bentri Alwen , Hidayati Abna , Kristiawan Muhammad
Published: November 2022

Teachers must have digital pedagogical competency in order to instruct their pupils in the 4.0 industrial revolution age. The creative ability of educators in West Sumatra is insufficient. As a result, they must be able to employ a variety of learning strategies. The goal of this research is to discover the factors that contribute to teachers’ mastery of digital pedagogical competence and to analyze their digital pedagogical competence. This study used a sample size of 94 teachers from three locations, namely, Padang, Bukit Tinggi, and Solok, based on their educational level, age, and gender. The information was gathered through the use of questionnaires, which had been verified for validity and reliability. The findings revealed that there are characteristics that promote instructors’ ability to construct digital tools for analysis and assessment. It is suggested that systematic training must be provided for the development of digital pedagogical competency.
High expression of TTC21A predicts unfavorable prognosis and immune infiltrates in clear cell renal cell carcinoma
Authors: Lin Junhao , Nong DeYong , Wang Wei , Guo Xiaobin , Li ChunLin , Li BingCai , Wang Haojian , Chen Zhi , Li XiMing , Huang GuiHai , Li Wei
Published: November 2022

Background: Clear cell renal cell carcinoma (ccRCC) is the most common pathological type of renal cell carcinoma. Tetratricopeptide repeat domain 21A (TTC21A), known as a component of intraflagellar transport complex A which is essential for the function of cilia, However, the role of TTC21A remains unclear in ccRCC. For the first time, we explore the role and potential mechanism of TTC21A in ccRCC based on multiple databases.

Methods: TTC21A expression across all TCGA tumor was analyzed via Tumor Immune Estimation Resource (TIMER) site. The correlation between TTC21A and clinicopathologic characteristics of ccRCC was analyzed with TCGA database. The diagnostic and prognostic value of TTC21A was evaluated by receiver operation characteristic curve, Kaplan-Meier plotter and Cox regression respectively. Moreover, functional enrichment analysis of TTC21A and the co-expression genes were performed by Gene Set Enrichment Analysis. The correlation of TTC21A and immune infiltration were evaluated by single sample Gene Set Enrichment Analysis.

Results: Pan-cancer analysis indicated that TTC21A was highly expressed in ccRCC and other cancer. In addition, elevated expression of TTC21A was associated with worse overall survival in ccRCC patients. Functional enrichment analysis showed that TTC21A and the co-expressed genes enriched in glucose metabolism and energy metabolism. Moreover, TTC21A expression was associated with infiltrating levels of dendritic cell, nature killer cell and other immune marker sets.

Conclusion: The results of analysis indicate that expression of TTC21A is associated with poor prognosis and immune infiltrating in ccRCC, which suggested TTC21A might be used as a potential predictor and target of treatment in ccRCC.