bluuebunny/crossref_metadata_2025 huggingface dataset:
Epilepsy Detection Based on Riemann Potato in Noisy Environment
Authors: Ru Yandong , Li Jinbai , Wei Zheng
Published: June 2022

Epilepsy detection based on electroencephalogram (EEG) is important for the diagnosis and treatment of epilepsy. The existing feature extraction method not only consumes a lot of time but also leads to epilepsy information loss because of nonideal denoising. Therefore, the paper proposes to use noisy EEG signals to detect epilepsy. The original EEG signal is divided into normal signal and abnormal signal by Riemann potato, and the epilepsy detection model is established based on the normal signal and abnormal signal, respectively. Finally, the 2 detection results are combined as a final result. The detection performance of 94.84%, 83.03% sensitivity, and 97.67% specificity is achieved. The experimental results show that the original noisy signal which is separated by the Riemann potato can have high epilepsy detection performance.
Immunokinetic Model for COVID‐19 Patients
Authors: Fadaei Y. , Rihan F. A. , Rajivganthi C.
Published: June 2022

In this paper, we develop a fractional‐order differential model for the dynamics of immune responses to SARS‐CoV‐2 viral load in one host. In the model, a fractional‐order derivative is incorporated to represent the effects of temporal long‐run memory on immune cells and tissues for any age group of patients. The population of cytotoxic T cells (CD8+), natural killer (NK) cells, and infected viruses is unknown in this model. Some interesting sufficient conditions that ensure the asymptotic stability of the steady states are obtained. This model indicates some complex phenomena in COVID‐19 such as “immune exhaustion” and “long COVID.” Sensitivity analysis is also investigated for model parameters to determine the parameters that are effective in disease control and future treatment as well as vaccine design. The model is verified with clinical and experimental data of 5 patients with COVID‐19.
The Use of Deep Learning Model for Effect Analysis of Conventional Friction Power Confinement
Authors: Liu Chuntong , Wang Xin , He Zhenxin
Published: June 2022

Nonlinear friction could affect the high-precision motion system, resulting in poor tracking accuracy in the end. This is due to the fact that the Lugre friction model’s parameter identification process comprises both static and dynamic parameter identification. The convolutional neural network (CNN) model is used in this study to create the friction identification system. We suggest a hybrid methodology that combines the CNN method and the classic least-squares technique. The convolutional layer (CONV), which is defined by a convolutional kernel, analyzes and extracts features from an input image. In terms of accuracy and convergence, the results reveal that the upgraded CNN friction model outperforms the original CNN friction model. You may successfully reduce the influence of friction on your system while improving its performance by applying the feedforward correction.
Active Flow Control of Helicopter Rotor Based on Coflow Jet
Authors: Liu Jiaqi , Chen Rongqian , Song Qiaochu , You Yancheng , Shi Zheyu
Published: June 2022

When a helicopter rotor undergoes flow separation, the drag of the rotor increases substantially, as does the power demand, which seriously affects the aerodynamic performance and flight safety of the helicopter. Therefore, it is crucial to research how to suppress the flow separation of rotor blades. An active control technique based on a coflow jet (CFJ) at the rotor blade tip was employed in this study to suppress the flow separation over the rotor. The mechanisms and behavior were investigated. The rotor flow field was numerically simulated by solving the Reynolds-averaged Navier–Stokes equations with the finite volume method. The turbulence model was

k
−
ω

SST, and the rotor motion was simulated using the overset mesh technique. After applying CFJ control, the airflow from the injection slot at the leading edge of the rotor increased the energy of the mainstream in the near-wall area, which enhanced its ability to resist the adverse pressure gradient. A flow separation was effectively suppressed, both on the advancing and retreating sides, which improved the aerodynamic performance of the rotor. During the whole rotation period, the thrust coefficient of the rotor increased by up to 5.6%, the moment coefficient decreased by as much as 26.8%, and the equivalent lift-to-drag ratio increased by up to 44.0%. Moreover, the effects of the CFJ parameters on the flow separation suppression of the rotor are researched. These results may provide a foundation for the development of aerodynamic performance improvement for helicopter rotor based on a CFJ.
Evaluation of the Mechanism of Jiedu Huazhuo Quyu Formula in Treating Wilson’s Disease-Associated Liver Fibrosis by Network Pharmacology Analysis and Molecular Dynamics Simulation
Authors: Huang Shao-Peng , Chen Sen , Ma Yan-Zhen , Zhou An , Jiang Hui , Wu Peng
Published: June 2022

The Jiedu Huazhuo Quyu formula (JHQ) shows significant beneficial effects against liver fibrosis caused by Wilson’s disease (WD). Hence, this study aimed to clarify the mechanisms of the JHQ treatment in WD-associated liver fibrosis. First, we collected 103 active compounds and 527 related targets of JHQ and 1187 targets related to WD-associated liver fibrosis from multiple databases. Next, 113 overlapping genes (OGEs) were obtained. Then, we built a protein-protein interaction (PPI) network with Cytoscape 3.7.2 software and performed the Gene Ontology (GO) term and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment analyses with GENE DENOVO online sites. Furthermore, module analysis was performed, and the core target genes in the JHQ treatment of WD-associated liver fibrosis were obtained. Pathway and functional enrichment analyses, molecular docking studies, molecular dynamic (MD) simulation, and Western blot (WB) were then performed. The results indicated that 8 key active compounds including quercetin, luteolin, and obacunone in JHQ might affect the 6 core proteins including CXCL8, MAPK1, and AKT1 and 107 related signaling pathways including EGFR tyrosine kinase inhibitor resistance, Kaposi sarcoma-associated herpesvirus infection, and human cytomegalovirus infection signaling pathways to exhibit curative effects on WD-associated liver fibrosis. Mechanistically, JHQ might inhibit liver inflammatory processes and vascular hyperplasia, regulate the cell cycle, and suppress both the activation and proliferation of hepatic stellate cells (HSCs). This study provides novel insights for researchers to systematically explore the mechanism of JHQ in treating WD-associated liver fibrosis.
Analysis of Rational Finite Element Model of Two‐Span Skew Girder Bridge Based on Shaking Table Test
Authors: Huang Ying , Xu Yongji
Published: June 2022

Based on the shaking table test, the seismic responses of the main parameters of the two‐span skew bridge were gutted. The finite element model of the test model was established by the finite element analysis software OpenSEES. An improved model of single beam quality distribution was proposed. The stiffness of the end beam of the improved single beam model was twice that of the actual end beam, rather than the rigid arm. At the same time, the main beam mass was distributed in the way that the single beam shares half and the beams at both ends share half, taking into account the torsion of the beam body. Three‐direction ground motion input analysis was carried out to improve the quality distribution model of the single beam, and the seismic response of the structure under the three‐direction ground motion input was obtained, and the comparison was made between the analytical results and experimental results. The results show that the improved single beam quality distribution model can consider the torsion effect of the beam, while the result of the analysis was greatly improved, which was more close to the experimental value, and could greatly improve the efficiency of the calculation.
Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study
Authors: Weber Manuel , Kersting David , Riemann Burkhard , Brandenburg Tim , Führer-Sakel Dagmar , Grünwald Frank , Kreissl Michael C. , Dralle Henning , Weber Frank , Schmid Kurt Werner , Herrmann Ken , Jentzen Walter , Grafe Hong , Rischpler Christoph , Theurer Sarah , Bockisch Andreas , Nagarajah James , Fendler Wolfgang P.
Published: June 2022

Purpose:

Restoration of iodine incorporation (redifferentiation) by MAPK inhibition was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma (RR-TC). However, results were unsatisfactory in BRAFV600E-mutant (BRAF-MUT) RR-TC. Here we assess safety and efficacy of redifferentiation therapy through genotype-guided MAPK-modulation in patients with BRAF-MUT or wildtype (BRAF-WT) RR-TC.

Patients and Methods:

In this prospective single-center, two-arm phase II study, patients received trametinib (BRAF-WT) or trametinib + dabrafenib (BRAF-MUT) for 21 ± 3 days. Redifferentiation was assessed by 123I-scintigraphy. In case of restored radioiodine uptake, 124I-guided 131I therapy was performed. Primary endpoint was the redifferentiation rate. Secondary endpoints were treatment response (thyroglobulin, RECIST 1.1) and safety. Parameters predicting successful redifferentiation were assessed using a receiver operating characteristic analysis and Youden J statistic.

Results:

Redifferentiation was achieved in 7 of 20 (35%) patients, 2 of 6 (33%) in the BRAF-MUT and 5 of 14 (36%) in the BRAF-WT arm. Patients received a mean (range) activity of 300.0 (273.0–421.6) mCi for 131I therapy. Any thyroglobulin decline was seen in 57% (4/7) of the patients, RECIST 1.1 stable/partial response/progressive disease in 71% (5/7)/14% (1/7)/14% (1/7). Peak standardized uptake value (SUVpeak) < 10 on 2[18F]fluoro-2-deoxy-D-glucose (FDG)-PET was associated with successful redifferentiation (P = 0.01). Transient pyrexia (grade 3) and rash (grade 4) were noted in one patient each.

Conclusions:

Genotype-guided MAPK inhibition was safe and resulted in successful redifferentiation in about one third of patients in each arm. Subsequent 131I therapy led to a thyroglobulin (Tg) decline in more than half of the treated patients. Low tumor glycolytic rate as assessed by FDG-PET is predictive of redifferentiation success.

See related commentary by Cabanillas et al., p. 4164
Early Response to Endovascular Thrombectomy after Stroke: Early, Late, and Very Late Time Windows
Authors: Ha Sang Hee , Ryu Jae-Chan , Bae Jae-Han , Koo Sujin , Kwon Boseong , Lee Deok Hee , Chang Jun Young , Kang Dong-Wha , Kwon Sun U. , Kim Jong-Sung , Kim Bum Joon
Published: June 2022

Background and Purpose: Endovascular thrombectomy (EVT) has benefits in selected patients 6–24 h after stroke onset. However, the response to EVT >24 h after stroke onset is still unclear. We compared the early response to EVT in patients with different time windows. Methods: Patients who underwent EVT in an emergency setting were enrolled and categorized according to when EVT was performed: within 6 (early), 6–24 (late), and >24 h (very late) after stroke onset. Early neurological improvement (ENI) and deterioration (END) were defined as improvement and worsening, respectively, of National Institutes of Health Stroke Scale (NIHSS) score by ≥4 points after EVT. The three groups’ clinical characteristics and response to EVT were compared. We also investigated factors associated with ENI and END. Results: During study period, 274 patients underwent EVT (109 early, 104 late, and 61 very late). Patients who underwent EVT very late were younger (p = 0.007), had smaller ischemic cores, and had lower initial NIHSS scores (8 ± 5) than those who underwent EVT early (14 ± 6) and late (13 ± 7; p < 0.001). Stroke mechanisms also differed according to the time window (p < 0.001): cardioembolism was more common after early EVT, whereas large-artery atherosclerosis was more prevalent among patients who underwent EVT very late. ENI was significantly more common after early (60.6%) and late EVT (51.0%) than after very late EVT (29.5%; p = 0.001); however, rates of END did not differ (11.0%, 13.5%, and 4.9%, respectively). ENI was independently associated with male, higher NIHSS score, and early and late EVT. END was associated with failure of recanalization. Conclusions: ENI was more observed and associated with early and late EVT. Highly selected patients receiving very late EVT may not benefit from ENI but may still have a chance to prevent END. The occurrence of END was associated not with time window but with failure of recanalization.
Prognosis of Patients with Bronchopulmonary Neuroendocrine Neoplasms in a Tertiary Neuroendocrine Tumor Centre of Excellence
Authors: Rewitz Karina Stubkjær , Grønbæk Henning , Tabaksblat Elizaveta Mitkina , Dahl Baunwall Simon Mark , Dam Gitte
Published: June 2022

Introduction: The European Neuroendocrine Tumor Society (ENETS) reports variables of prognostic significance in bronchopulmonary neuroendocrine neoplasms (BP-NENs). The aim of this study was to investigate prognostic factors, recurrence-free survival (RFS), and overall survival (OS) for patients with typical carcinoid (TC), atypical carcinoid (AC), and large-cell neuroendocrine carcinoma (LCNEC). Current follow-up practices vary as the evidence is sparse, and we aimed to explore the relevance of routine bronchoscopy in follow-up. Methods: This was a cohort study of 208 patients with BP-NENs followed at Aarhus University Hospital in 2008–2019. RFS and OS were determined using the Kaplan-Meier method for the variables such as primary tumor, primary treatment, smoking status, gender, and histological subtypes. Results: The study included 153 patients with TC, 29 with AC, and 26 with LCNEC. Median follow-up was 48 months. The majority of patients (n = 191) received surgical resection, of which 22 (11%) recurred over time. Seventeen patients had nonsurgical treatment, of which 10 (59%) progressed. The 5-year OS rate was 86% for operated and 9% for nonoperated patients (p < 0.05). Patients with TC had a 5-year OS of 90% compared with 63% and 39% for AC and LCNEC, respectively. As for prognostic factors, nonsmokers did not secure a significant difference in OS compared with current/previous smokers (p = 0.51). In the follow-up period, only 2 (9%) of the 22 recurrences were found on a routine bronchoscopy. Both of these recurrences were also found by diagnostic imaging. Conclusions: Surgical treatment, especially, and diagnosis of TC were associated with a good prognosis. Furthermore, our data did not support routine bronchoscopy as part of a follow-up program for bronchial carcinoids.
Padrão respiratório em pacientes portadores da doença de parkinson e em idosos assintomáticos
Authors: Parreira Verônica Franco , Guedes Luciana Ulhôa , Quintão Dalila Godoy , Silveira Eduardo Paolineli , Tomich Georgia Miranda , Sampaio Rosana Ferreira , Britto Raquel Rodrigues , Goulart Fátima
Published: June 2022

Objetivo: Caracterizar diferentes componentes do padrão respiratório em pacientes portadores da Doença de Parkinson (DP) e em idosos assintomáticos. Método: Foram estudados 10 pacientes com DP com grau de acometimento III-IV segundo a escala de Hoehn e Yahr e 10 idosos assintomáticos. Variáveis respiratórias analisadas: volume corrente, freqüência respiratória, ventilação minuto, porcentagem do tempo inspiratório, fluxo inspiratório médio, contribuição da caixa torácica e do abdômen para o volume corrente, através da pletismografia respiratória por indutância calibrada. A análise estatística foi feita através do teste t de Student para grupos independentes. Resultados: Os pacientes com DP apresentaram volume corrente e fluxo inspiratório médio menores (p=0,01 e p=0,03 respectivamente), uma freqüência respiratória maior (p=0,03), resultando numa ventilação minuto significativamente menor (p=0,02) comparados aos idosos assintomáticos. Não houve diferença significativa em relação à contribuição da caixa torácica e do abdômen entre os dois grupos. Conclusão: Estes resultados apontaram alterações importantes em diferentes componentes do padrão respiratório em pacientes portadores da DP.
Pés reumatóides: avaliação pela podobarometria dinâmica computadorizada e restauração funcional com órteses plantares
Authors: Magalhães Eduardo de Paiva , Jorge Filho Donaldo , Battistella Linamara Rizzo
Published: June 2022

Os pés são comumente acometidos na artrite reumatóide (AR), contribuindo em muito na dor e incapacidade observadas nessa doença. Este artigo descreve uma paciente com pés reumatóides, tratada com órteses para os pés. Foram discutidas as alterações mais freqüentes observadas nessa patologia, o tratamento com palmilhas e o uso da podobarometria dinâmica computadorizada (F-Scan) como método auxiliar diagnóstico e de acompanhamento.
Humanização, equipes multidisciplinares e a prática do médico fisiatra
Authors: Battistella Linamara Rizzo
Published: June 2022

“Não se trata de somente assistir o doente, mas também de fazer o possível para reintegrá-lo socialmente.” É cada vez mais importante a discussão sobre o significado da vida e do cuidado do ser humano. É preciso ter a clareza do entendimento do cuidar que é mais forte e mais importante do que tratar.
A barbárie do preconceito contra o deficiente: todos somos vítimas
Authors: Schewinsky Sandra Regina
Published: June 2022

O presente artigo refere-se a reflexões tanto sobre o preconceito em relação às pessoas portadoras de deficiência física, como sobre o sofrimento do preconceituoso. Baseia-se na perspectiva da Teoria Crítica, de acordo com os autores: Adorno, Horkheimer e Crochík. Inicialmente, haverá uma breve retrospectiva histórica em relação às ações preconceituosas e cruéis contra as pessoas portadoras de deficiência e sua posterior relação com a atualidade. Preconiza-se que o preconceito é um fenômeno psicológico que se dá no processo de socialização, discorre, sobre o sofrimento, crueldade e vergonha. Ressalta, por fim, a necessidade de uma compreensão crítica para melhorar as condições individuais e sociais de vida.
A importância do tratamento das síndromes dolorosas no traumatismo cranioencefálico
Authors: Sugawara André Tadeu , Jorge Liliana Lourenço , Fen Chien Hsin , Imamura Marta , Hsing Wu Tu
Published: June 2022

Segundo o modelo do National Center for Medical Rehabilitation Research, a doença crônica (como o traumatismo cranioencefálico) deve ser observada por meio de 5 eixos – a fisiopatologia, a deficiência observável (a hemiparesia), a limitação funcional (incapacidade para tarefa especifica), incapacidade para realização de atividades de vida diária, e limitação social. Levando em conta que tais aspectos sejam interrelacionados, a abordagem interdisciplinar é o método de escolha da prática da Medicina de Reabilitação. O objetivo do presente relato é confirmar a interferência da dor na reabilitação do traumatismo cranioencefálico (TCE), cuja importância muitas vezes é minimizada, apesar de crescentes estudos acerca da etiopatogenia e tratamento da dor no TCE. Foi realizado acompanhamento de uma paciente vítima de TCE na Divisão de Medicina Física do Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo em 2002, para quem diversas modalidades analgésicas foram propostas, além da aplicação de questionário funcional e sobre qualidade de vida, com melhora observada em todas as medidas. É necessária análise crítica dos instrumentos de medida de saúde, na medida em que neles se observa alta capacidade para detecção de habilidades motoras e baixa eficiência em detectar melhora da funcionalidade devido aos ganhos nos campos psicoafetivos e sociais, que são diretamente relacionado à experiência dolorosa
Reabilitação na hemipelvectomia traumática
Authors: Jorge Liliana Lourenço , Sugawara André Tadeu , Fen Chien Hsin , Oliveira Margarida Sales de , Pedrinelli André
Published: June 2022

A hemipelvectomia traumática constitui um evento raro, catastrófico, cujos mecanismos de lesão e prognóstico são bem descritos na literatura. O crescente número de acidentes motociclísticos têm elevado a prevalência desta amputação, definindo o grupo de vítimas como jovens do sexo masculino sem comorbidades. Acarreta múltiplas seqüelas físicas, psicológicas e sociais. Através da reabilitação, o paciente poderá recuperar a independência funcional. A protetização é de grande valia, uma vez que os pacientes são jovens e com prognóstico de marcha. Neste relato é apresentado o caso de uma vítima de hemipelvectomia traumática do sexo feminino, que se tornou independente para as atividades da vida diária após processo de reabilitação, que incluiu a prótese, com melhora da qualidade de vida observada sob diversos aspectos. A protetização adequada não devolveu à paciente todas as funções perdidas com a amputação, mas se constituiu em um instrumento capaz de melhorar a qualidade de vida.
Confiabilidade do teste palpatório e da unidade de biofeedback pressórico na ativação do músculo transverso abdominal em indivíduos normais
Authors: Costa Leonardo Oliveira Pena , Costa Lucíola da Cunha Menezes , Cançado Ricardo Lopes , Oliveira Warley de Melo , Ferreira Paulo Henrique
Published: June 2022

O objetivo deste artigo foi investigar a confiabilidade intra-examinador do teste palpatório e da Unidade de Biofeedback Pressórico (UBP), StabilizerÒ, na ativação do músculo Transverso Abdominal (TrA) em indivíduos assintomáticos. Foi realizado um estudo no desenho teste-reteste com um intervalo de sete dias entre as coletas em vinte e nove voluntários utilizando os dois testes. Os resultados indicaram uma confiabilidade substancial do teste palpatório (ICC= 0,70) e moderada do teste UBP (ICC= 0,50), houve uma correlação positiva e significativa entre os dois testes (0,990 p<0,01). Conclui-se que o teste palpatório e a UBP são ferramentas confiáveis para avaliar a ativação do TrA e que esta metodologia de análise pode ser empregada em tratamentos e estudos clínicos.
Perfil dos pacientes hemiplégicos atendidos no Lar Escola São Francisco - Centro de Reabilitação
Authors: Bruno Auri de Abreu , Farias Carolinne Atta , Iryia Guilherme Tsutomu , Masiero Danilo
Published: June 2022

Realizamos um estudo retrospectivo por meio do levantamento de 147 prontuários de pacientes hemiplégicos atendidos na Disciplina de Fisiatria do Departamento de Ortopedia e Traumatologia da Universidade Federal de São Paulo/Escola Paulista de Medicina – Lar Escola São Francisco – Centro de Reabilitação. O período escolhido, janeiro de 1995 a dezembro de 1998, foi posterior à implantação dos grupos de hemiplegia, com o objetivo de conhecermos o perfil dos hemiplégicos atendidos na instituição, compararmos o tempo de permanência entre o atendimento individual e o em grupo, para auxiliar na otimização do tratamento. Os autores observaram predomínio da hemiplegia no sexo masculino e no hemicorpo direito. A maioria era constituída de pacientes atendidos pelo Sistema Único de Saúde, tendo freqüentado terapias 2 vezes por semana com duração de 1 hora, em grupo de 4 a 6 pacientes. A principal etiologia encontrada foi a lesão isquêmica. O tempo de permanência na instituição variou de 2 meses a 2 anos, com a média de permanência muito acima dos critérios de prognóstico descritos na literatura mundial, o que deveremos rever para os tratamentos futuros.
Relação entre lordose lombar e desempenho da musculatura abdominal em alunos de fisioterapia
Authors: Pinto Roberta Ramos , Guerino Christiane de Souza , Consolin Daniela Bittencourt , Cunha Ana Cláudia Violino da
Published: June 2022

Sabendo-se que a metade do peso corporal está em equilíbrio estável sobre a coluna lombar, toda a musculatura estabilizadora desta região é importante, em especial os músculos abdominais. Esses músculos revestem as paredes laterais, anterior e posterior do abdome, agindo como uma espécie de cinta que contém as vísceras, auxiliam no equilíbrio e atuam diretamente na estática e na dinâmica da pelve, sendo muito importante para a postura do corpo. Não há comprovação científica de que a habilidade da musculatura abdominal esteja realmente relacionada com a postura ereta relaxada e conseqüentemente com a angulação lordótica lombar. Com o objetivo de relacionar a força abdominal e o ângulo da lordose lombar, foi utilizado como medida o ângulo da lordose lombar com o auxílio de radiografias da região lombar realizadas com o indivíduo em posição ortostática, e a performance abdominal com o auxílio de um esfigmomanômetro. Para esse estudo foram avaliados 50 alunos assintomáticos do curso de fisioterapia da Universidade Estadual de Londrina, com idade média entre 22,08 anos; destes, 5 eram homens e 45, mulheres. Como resultado, não foi encontrada correlação significante entre os parâmetros analisados.
Fatores ambientais que influenciam a plasticidade do SNC
Authors: Oliveira Claudia Eunice Neves de , Salina Maria Elisabete , Annunciato Nelson Francisco
Published: June 2022

O SNC possui uma rede neural complexa, com células altamente especializadas, que fazem milhares de conexões a todo momento e determinam a sensibilidade e as ações motoras, traduzindo-as em comportamento. Na presença de lesões, há um desarranjo nesta rede neural e o SNC inicia seus processos de reorganização e regeneração. A plasticidade neural refere-se à capacidade que o SN possui em alterar algumas das suas propriedades morfológicas e funcionais em resposta às alterações do ambiente. A análise dos aspectos plásticos do SNC permite-nos relacioná-los a vários fatores, como a influência do meio ambiente, o estado emocional, o nível cognitivo, entre outros, que interferem direta ou indiretamente na plasticidade do SNC e, conseqüentemente, na reabilitação do paciente neurológico. Assim, por meio da revisão da literatura, procuramos uma fundamentação teórica, a qual trará bases para a prática clínica, buscando uma nova visão sobre as perspectivas de reabilitação do paciente neurológico adulto.
Hemartroses recidivantes do tornozelo em hemofílicos – Diagnóstico funcional pela podobarometria dinâmica computadorizada e uso profilático de órteses para os pés: relato de um caso
Authors: Battistella Linamara Rizzo , Lourenço Claudete , Jorge Filho Donaldo
Published: June 2022

Devido ao grande número depacientes hemofílicos, com hemartroses de repetição no tornozelo, que se apresentavam freqüentemente para tratamento no Ambulatório de Reabilitação de Hemofílicos da (DMR) – Divisão de Medicina de Reabilitação do (HCFMUSP) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, os autores decidiram avaliá-los mediante um protocolo em que, além do exame físico de rotina e de algumas medidas radiológicas, se procedesse à podoscopia estática e à podobarometria dinâmica computadorizada. Os resultados obtidos serviram de base para a elaboração de palmilhas ortopédicas e/ou para a prescrição de órteses para a estabilização do tornozelo todas as vezes que uma instabilidade médio-lateral do tornozelo e/ou uma discrepância no comprimento dos membros inferiores eram observadas. O uso continuado dessas órteses vem impedindo, nos últimos seis meses, a ocorrência de novos episódios de hemartrose no tornozelo dos pacientes avaliados. Essa constatação levou os autores a acreditar que os desvios articulares nas atividades repetitivas, como a marcha, é que predispõem à ocorrência das hemartroses. Desse modo, a estabilização das articulações, pelo uso das órteses para os pés, seria a melhor maneira de evitar as hemartroses de repetição nos tornozelos. Os bons resultados obtidos até agora, nos pacientes avaliados e reavaliados após seis meses, animaram os autores a desenvolver duas diferentes linhas de pesquisa: para hemofílicos com tornozelos instáveis e para hemofílicos com joelhos instáveis.
Dispositivo para emulação de mouse dedicado a pacientes tetraplégicos ou portadores de doença degenerativa do sistema neuromuscular
Authors: Müller André Frotta , Zaro Milton Antônio , Silva Junior Danton Pereira da , Sanches Paulo Roberto Stefani , Ferlin Elton Luiz , Thomé Paulo Ricardo Oppermann , Santos Antônio Cardoso dos , Tarrago Maria da Graça
Published: June 2022

O trabalho descreve o desenvolvimento de um dispositivo que emula um mouse serial MicrosoftÒ. Este dispositivo permite ao deficiente físico tetraplégico acessar os recursos de informática em ambiente WindowsÒ 95/98 (ler e editar textos, navegar na Internet e utilizar o correio eletrônico) e auxilia o paciente de doenças degenerativas do sistema neuromuscular, como a esclerose lateral amiotrófica (ELA), com disartria, a comunicar-se com as pessoas ao seu redor. O movimento do cursor na tela do computador é produzido a partir do movimento de flexão e extensão da cabeça do usuário, sendo utilizado para medir os ângulos de inclinação um sensor de aceleração estática e dinâmica de dois eixos. Para emular o botão do mouse, são captados os sinais EMG (eletromiográficos) produzidos a partir do movimento voluntário dos músculos mímicos da região frontal do usuário. O processamento digital é realizado por um microcontrolador de oito bits e os dados são transmitidos para um computador padrão IBM-PC através da interface RS232C.
O fisiatra trata do quê?
Authors: Saad Marcelo
Published: June 2022

A Fisiatria é talvez a especialidade médica que mais traga para o centro da atenção a integração biopsicossocial do ser humano. Além de se preocupar com a doença, preocupa-se também com o modo como esta doença impede o indivíduo de ser uma pessoa completa. Talvez a Fisiatria tenha sido uma revolução entre as especialidades médicas. Ela trouxe um conceito tão inovador que, mesmo passadas tantas décadas, ainda tentam delimitar exatamente qual o campo de atuação da Fisiatria. Ela talvez dê oportunidade de se exercer a medicina de uma forma mais espiritualizada. O problema do esclarecimento da população e da classe médica sobre a Fisiatria exige nosso empenho paciente e desprovido de irritação diante da desinformação.
Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy
Authors: De Jong Hannah N. , Dewey Frederick E. , Cordero Pablo , Victorio Rachelle A. , Kirillova Anna , Huang Yong , Madhvani Roshni , Seo Kinya , Werdich Andreas A. , Lan Feng , Orcholski Mark , Liu W. Robert , Erbilgin Ayca , Wheeler Matthew T. , Chen Rui , Pan Stephen , Kim Young M. , Bommakanti Krishna , Marcou Cherisse A. , Bos J. Martijn , Haddad Francois , Ackerman Michael , Vasan Ramachandran S. , MacRae Calum , Wu Joseph C. , de Jesus Perez Vinicio , Snyder Michael , Parikh Victoria N. , Ashley Euan A.
Published: June 2022

Background:

The study of hypertrophic cardiomyopathy (HCM) can yield insight into the mechanisms underlying the complex trait of cardiac hypertrophy. To date, most genetic variants associated with HCM have been found in sarcomeric genes. Here, we describe a novel HCM-associated variant in the noncanonical Wnt signaling interactor
WTIP
(Wilms tumor interacting protein) and provide evidence of a role for WTIP in complex disease.

Methods:

In a family affected by HCM, we used exome sequencing and identity-by-descent analysis to identify a novel variant in WTIP (p.Y233F). We knocked down WTIP in isolated neonatal rat ventricular myocytes with lentivirally delivered short hairpin ribonucleic acids and in
Danio rerio
via morpholino injection. We performed weighted gene coexpression network analysis for WTIP in human cardiac tissue, as well as association analysis for WTIP variation and left ventricular hypertrophy. Finally, we generated induced pluripotent stem cell–derived cardiomyocytes from patient tissue, characterized size and calcium cycling, and determined the effect of verapamil treatment on calcium dynamics.

Results:

WTIP knockdown caused hypertrophy in neonatal rat ventricular myocytes and increased cardiac hypertrophy, peak calcium, and resting calcium in
D rerio
. Network analysis of human cardiac tissue indicated WTIP as a central coordinator of prohypertrophic networks, while common variation at the
WTIP
locus was associated with human left ventricular hypertrophy. Patient-derived
WTIP
p.Y233F-induced pluripotent stem cell–derived cardiomyocytes recapitulated cellular hypertrophy and increased resting calcium, which was ameliorated by verapamil.

Conclusions:

We demonstrate that a novel genetic variant found in a family with HCM disrupts binding to a known Wnt signaling protein, misregulating cardiomyocyte calcium dynamics. Further, in orthogonal model systems, we show that expression of the gene
WTIP
is important in complex cardiac hypertrophy phenotypes. These findings, derived from the observation of a rare Mendelian disease variant, uncover a novel disease mechanism with implications across diverse forms of cardiac hypertrophy.
Position Information in Transformers: An Overview
Authors: Dufter Philipp , Schmitt Martin , Schütze Hinrich
Published: June 2022

Transformers are arguably the main workhorse in recent natural language processing research. By definition, a Transformer is invariant with respect to reordering of the input. However, language is inherently sequential and word order is essential to the semantics and syntax of an utterance. In this article, we provide an overview and theoretical comparison of existing methods to incorporate position information into Transformer models. The objectives of this survey are to (1) showcase that position information in Transformer is a vibrant and extensive research area; (2) enable the reader to compare existing methods by providing a unified notation and systematization of different approaches along important model dimensions; (3) indicate what characteristics of an application should be taken into account when selecting a position encoding; and (4) provide stimuli for future research.
Sensitivity of Sparse Codes to Image Distortions
Authors: Luther Kyle , Seung H. Sebastian
Published: June 2022

Sparse coding has been proposed as a theory of visual cortex and as an unsupervised algorithm for learning representations. We show empirically with the MNIST data set that sparse codes can be very sensitive to image distortions, a behavior that may hinder invariant object recognition. A locally linear analysis suggests that the sensitivity is due to the existence of linear combinations of active dictionary elements with high cancellation. A nearest-neighbor classifier is shown to perform worse on sparse codes than original images. For a linear classifier with a sufficiently large number of labeled examples, sparse codes are shown to yield higher accuracy than original images, but no higher than a representation computed by a random feedforward net. Sensitivity to distortions seems to be a basic property of sparse codes, and one should be aware of this property when applying sparse codes to invariant object recognition.
Toward a Biomimetic Neural Circuit Model of Sensory-Motor Processing
Authors: Lisberger Stephen G.
Published: June 2022

Computational models have been a mainstay of research on smooth pursuit eye movements in monkeys. Pursuit is a sensory-motor system that is driven by the visual motion of small targets. It creates a smooth eye movement that accelerates up to target speed and tracks the moving target essentially perfectly. In this review of my laboratory's research, I trace the development of computational models of pursuit eye movements from the early control-theory models to the most recent neural circuit models. I outline a combined experimental and computational plan to move the models to the next level. Finally, I explain why research on nonhuman primates is so critical to the development of the neural circuit models I think we need.
Integrating information practices into everyday teaching
Authors: Phillips Jonathan William , Whitworth Andrew
Published: June 2022

This paper reports on the information practices and information literacy (IL) skills of South Korean elementary school students from the perspectives of working teachers. Key to this investigation was the notion of information practice, and how this is shaped by the practice architecture found in an educational setting. A sequential mixed design was undertaken to investigate these ideas which consisted of exploratory interviews with 4 elementary school teachers and was followed by a questionnaire which analysed the responses of 314 elementary school teachers. Findings indicate that in this setting, teachers, students and pre-set curricular content serve as the most frequently used information sources for students during their everyday classes. We pay specific attention to the ongoing centrality of the textbook, in its traditional paper format, to the ways in which teachers design learning activities, and suggest that this limits the diversity of informational approaches to which young South Korean learners are exposed. While these learners are engaged, they are limited in terms of informational genre since teachers and textbooks were found to be dominant information proxies. Activities in which students engage in active seeking or scanning are rarer. Contexts with such a configuration may be hindering the development of critical information literacy skills that are vital in dealing with the abundance of information faced by individuals today.
The development and use of online information literacy activities to engage first year health students during the COVID-19 pandemic
Authors: Siddall Gillian
Published: June 2022

The article discusses the development of online tutorials to support the Academic Librarians’ information literacy instruction during the first lockdown of the COVID-19 pandemic. The content and development of the activities are presented in relation to information literacy (IL) standards. At the University of Northampton, the first-year students each receive two IL sessions from an Academic Librarian that support their information skills development. The first session focuses on identifying an information need and how to search for relevant information. The second session supports students to understand the referencing process and how to use information ethically. The IL sessions are based on the principles of Active Blended Learning and focus on providing interactive and engaging workshops for students. The activities were designed to support the students on health programmes who began their studies in April 2020 and the students who were receiving their final IL session. The reflections on the IL sessions highlight lessons learnt during the online delivery.
(Re)constructing Ageing Futures: Insights from Migration in Asia and Beyond
Authors: Ho Elaine Lynn-Ee , Thang Leng Leng , Huang Shirlena , Yeoh Brenda S.A.
Published: June 2022

This special issue examines how older adults anticipate and manage their futures through migration. Although ageing is often associated with decline towards the end-of-life, it is still a life stage where (the lack of) planning for the future can profoundly impact the life outcomes of older adults and their caregivers. This collection illustrates different ways migration can impact ageing. For some, perceptions and depictions of the future lead older adults to turn to migration to improve their prospects of ageing well although they continue to face constraints while ageing abroad. For others, the migration of younger family members exacerbates the stress of eldercare felt by non-migrant caregivers. Collectively, the papers focus on how countries in Asia function as source and destination sites for ageing-related migration, while also forging transnational connections with the Global North. Focusing on ageing futures allows us to link the current and future lives of migrants and non-migrants, across generations and space.
Leveraging Community-Driven Anchor Activities Among US For-Profit Hospitals
Authors: Choyke Kelly Lynn , Cronin Cory Edward , Franz Berkeley
Published: June 2022

Hospitals have the ability to serve as anchor institutions that not only provide clinical care but make important community investments through employment, and outreach, and engagement efforts that address the social determinants of health. In doing so, hospitals may partner with community members and community-based organizations, but the extent to which local residents participate in directing local investments varies across organizations. This study looks at the role of hospitals as anchor institutions and the best practices for leveraging community participation in planning investments to improve social and economic health in communities. We used an inductive, qualitative approach to understand the incentives hospitals have to anchor themselves within their communities and how best practices can be leveraged. We conducted 28 in-depth interviews with 27 hospital leaders and personnel, and one interview with a member of a for-profit hospital advocacy organization. Drawing on thematic analysis, three primary themes were identified as critical to leveraging community-driven anchor activities: strong and intentional community-oriented leadership; direct community involvement; and non-regulatory incentives, including incentive programs. The more institutions, organizations, communities, and individuals expect community-oriented anchor activities from hospitals, the more likely they are to engage in such activities. Critical to this work is ensuring that community members themselves are able to help direct the investments of hospitals in alignment with community health needs. Community stakeholders, including elected officials, public health offices, and policymakers, have important leverage in creating expectations for hospitals to engage in anchor activities and facilitate community-based partnerships as a part of this process.
Efficacy of Mid-Day Meal Scheme in India: Challenges and Policy Concerns
Authors: Paltasingh Tattwamasi , Bhue Prakash
Published: June 2022

The Mid-Day Meal Scheme (MDMS) in India is considered to be the world’s largest school meal programme, serving hot cooked meals to the underprivileged children. The ideas behind the introduction of this programme are to remove malnutrition, supplement nutritional foods in school meals, to motivate out-school children towards regular school, to decrease absenteeism and dropout rate, and to bridge inequality among the children irrespective of their caste, class and gender backgrounds. After the enactment of the Right of Children to Free and Compulsory Education Act (RTE), 2009, the programme is being monitored by the School Management Committees. The article intends to highlight the effectiveness of the MDMS in improving schools and the local communities in India. It also focuses on the challenges being confronted with the implementation of the programme and suggests some relevant policy measures for reforms.
Data-driven performance evaluation of a low-cost seismograph
Authors: Krokidis Spiridon G. , Vlachos Ioannis , Avlonitis Markos , Kostoglou Anastasios , Karakostas Vasileios
Published: June 2022

The design and implementation of a performance protocol for local seismicity monitoring, is presented. A low-cost seismograph was installed in an area of high seismic activity in Evgiros, Lefkada Island, Greece, collocated with a high resolution 24-bit digitizer equipped with a broadband seismometer. A testing list of 28 local events with different epicenters and magnitudes has been compiled while acquisition data from the conventional seismograph and the proposed one were analyzed. Stochastic data analysis was used to compare these recordings on the same test site with different logging devices. The obtained results showed a satisfactory outcome in the performance of the proposed low-cost seismograph. Even though noise was present, P and S waves were clearly recorded with distinct amplitudes and therefore this arrival time difference, when compared with the one originating from the conventional seismograph, was found to be insignificant. Moreover, through a known magnitude equation, it manages to calculate earthquake’s local magnitude with a deviation of ± 0.4, a result that can be further improved. Lastly, spectral content analysis revealed almost identical waveforms with equivalent relative frequency distributions between the devices being compared.
Acceptability of reducing sedentariness using a mobile-phone application based on ‘if then’ plans for people with psychosis: A focus-group study conducted in North West England, UK
Authors: Bailey Rachel , Bartlett Y Kiera , Hassan Lamiece , Armitage Christopher J , Stockton-Powdrell Charlotte , Machin Matthew , Lewis Shon , Epton Tracy
Published: June 2022

Objective:

To understand the acceptability of (a) reducing sedentary-behaviour in people with psychosis using ‘if-then’ plans and (b) the proposed app content.

Design:

Qualitative acceptability study.

Method:

Three structured focus-groups and an interview were conducted with eight participants who had experience of a psychotic episode. They discussed sedentary-behaviour, being more active, critical situations in which they may be tempted to be sedentary and solutions to these (the if-then plans), and a mock-up of the mobile application. The Theoretical Framework of Acceptability (TFA) was used to analyse qualitatively the transcripts.

Results:

All TFA constructs were coded in each of the transcripts. The idea of reducing sedentary-behaviour was acceptable to people with psychosis, participants knew the importance of being more active, however it is not always their main priority. Likewise, the proposed content of the app was found to be acceptable, with participants already using some of the proposed solutions.

Conclusion:

This was the first study to use the TFA framework to assess the acceptability of an app that uses critical situations and solutions (‘if-then plans’) to help reduce sedentary behaviour for people with psychosis. In this sample (male, English speaking mainly white people), participants understood the benefits of being more active. However, reducing sedentary-behaviour is not the main priority of this population and being sedentary has benefits when their mental-health is bad.
Post-Conciliar Developments in the Catholic Doctrine of Charisms: Lumen Gentium and Iuvenescit Ecclesia Compared
Authors: Stayne John
Published: June 2022

The Congregation for the Doctrine of the Faith’s letter Iuvenescit Ecclesia represents a considerable, and largely unnoticed, development in the Catholic doctrine of the charisms. Despite being widely overlooked, this document contains a sophisticated, and quasi-systematic, theological presentation of the charismatic gifts. The present essay compares the teaching on the charisms in Iuvenescit Ecclesia with the earlier teaching in Lumen Gentium in three areas: (1) the wider theological grounding of the charisms; (2) the meaning of the term charism; (3) the value assigned to the charisms. Through this, the postconciliar developments in the area of the charisms are brought sharply into focus, demonstrating the significance of Iuvenescit Ecclesia for the future of Catholic ecclesiology.