bluuebunny/crossref_metadata_2025 huggingface dataset:
Does Long COVID Exist in Sub-Saharan Africa?
Authors: Mehta Natasha , Ndhlovu Chiratidzo E. , Makadzange Tariro
Published: July 2023

Billions of people have been impacted by the SARS-CoV-2 pandemic with over 600 million infections worldwide. Researchers have turned their attention to describing the post-viral phenomenon known commonly as “Long COVID”. While post-viral syndromes have been documented after other viral pandemics, the scale of the SARS-CoV-2 pandemic provides a unique opportunity to study and understand both the epidemiology and pathophysiology of the long COVID syndrome. While the pandemic impacted populations from all continents, there is a significant gap in what is known about long COVID on the sub-Saharan African continent. We review what is known about long COVID and highlight the need for further research within the African population.
Approaching Headaches—A Guide to Differential-Diagnostic Considerations and Causal Claims
Authors: Pohl Heiko
Published: July 2023

Headaches can be nociplastic, neuropathic, and nociceptive. Pain related to the latter two categories occurs in the presence of nerve lesions and nociceptive stimuli; attributing pain to the last category requires a list of potential causes and arguments supporting the causal claim. Taking a history and examining patients serves to assess diagnostic criteria and screen for disorders whose diagnosis requires additional examinations. Screening information occurs in two types: one indicates that patients have a headache due to another condition; the other suggests they are at risk. Aspiring to make causal claims for a headache is reasonable because if underlying disorders appear independently and randomly, it is probable that there is only one cause. Thus, having found a cause often implies having found the cause. The prerequisites for causal claims are temporal sequencing, correlation, and elimination of alternate causes. Mechanistic, manipulative, and probabilistic evidence supports the second criterion. The importance of headaches lies in their frequent appearance as an early symptom of an incipient disorder (“sentinel symptom”). Hence, they provide the opportunity to diagnose early diseases with potentially deleterious consequences. Thus, it is sensible to assess each attack carefully and systematically.
Microbiological Quality of Typical Traditional Fermented Milk from Northern Uganda and Western Kenya
Authors: Ogwaro Betty A. , Gibson Hazel , Hill Dave J. , O’Gara Elizabeth A.
Published: July 2023

In this study, the microbiological quality of traditionally fermented milk from Northern Uganda and Western Kenya was analysed. Six samples of typical traditionally fermented milk were collected randomly from traditional cattle keepers in Karamojong (UG 1) and Acholi (UG 2) in Northern Uganda and Kalenjin in Western Kenya (KE). The microbial quality of the collected samples was assessed through the use of conventional methods for total aerobic mesophilic bacteria, total coliform, lactic acid bacteria, Staphylococcus aureus, Listeria monocytogenes, yeasts, and mould counts. The mean aerobic mesophilic bacterial counts were 5.14 × 109 coliform forming units (cfu)/mL. The mean counts for mesophilic lactobacilli ranged from 106 to 108 cfu/mL. The mean thermophilic lactobacilli count ranged from 107 to 109 cfu/mL, while the mean thermophilic lactococci counts ranged from 106 to 109 cfu/mL. On the other hand, the Streptococci counts were between 106 and 108 cfu/mL. The mean count for the non-sorbitol E. coli was 3.87 × 103 cfu/mL. These results suggest that although the pH of the traditional yoghurt in this study was low, the acidity was not sufficient to inhibit growth of microorganisms in the product. Although it is difficult to avoid the microbial contamination of milk during milking, it is of the utmost importance to maintain a very high level of hygiene in dairy farming practices, and the correct cleaning of teats during milking is very important for good udder health and optimum milk quality, and to ensure safety. The results regarding microbial contamination pose public health concerns, and therefore the appropriate government agencies must pay attention to ensure that the environment in which yoghurt is produced is in the best condition to reduce contamination.
MET-Targeting Anticancer Drugs—De Novo Design and Identification by Drug Repurposing
Authors: To Kenneth Kin-Wah , Leung Kwong-Sak , Cho William Chi-Shing
Published: July 2023

The Met protein is a cell surface receptor tyrosine kinase predominantly expressed in epithelial cells. Aberrant regulation of MET is manifested by numerous mechanisms including amplification, mutations, deletion, fusion of the MET proto-oncogene, and protein overexpression. They represent the common causes of drug resistance to conventional and targeted chemotherapy in numerous cancer types. There is also accumulating evidence that MET/HGF signaling drives an immunosuppressive tumor microenvironment and dampens the efficacy of cancer immunotherapy. Substantial research effort has been invested in designing Met-targeting drugs with different mechanisms of action. In this review, we summarized the current preclinical and clinical research about the development of Met-targeting drugs for cancer therapeutics. Early attempts to evaluate Met-targeted therapies in clinical trials without selecting the appropriate patient population did not produce satisfactory outcomes. In the era of personalized medicine, cancer patients harboring MET exon 14 alterations or MET amplification have been found to respond well to Met-inhibitor therapy. The application of Met inhibitors to overcome drug resistance in cancer patients is discussed in this paper. Given that kinases play critical roles in cancer development, numerous kinase-mediated signaling pathways are attractive targets for cancer therapy. Existing kinase inhibitors have also been repurposed to new kinase targets or new indications in cancer. On the other hand, non-oncology drugs have also been repurposed for treating cancer through kinase inhibition as one of their reported anticancer mechanisms.
Exploring the Molecular Complexity of Medulloblastoma: Implications for Diagnosis and Treatment
Authors: Rechberger Julian S. , Toll Stephanie A. , Vanbilloen Wouter J. F. , Daniels David J. , Khatua Soumen
Published: July 2023

Medulloblastoma is the most common malignant brain tumor in children. Over the last few decades, significant progress has been made in revealing the key molecular underpinnings of this disease, leading to the identification of distinct molecular subgroups with different clinical outcomes. In this review, we provide an update on the molecular landscape of medulloblastoma and treatment strategies. We discuss the four main molecular subgroups (WNT-activated, SHH-activated, and non-WNT/non-SHH groups 3 and 4), highlighting the key genetic alterations and signaling pathways associated with each entity. Furthermore, we explore the emerging role of epigenetic regulation in medulloblastoma and the mechanism of resistance to therapy. We also delve into the latest developments in targeted therapies and immunotherapies. Continuing collaborative efforts are needed to further unravel the complex molecular mechanisms and profile optimal treatment for this devastating disease.
Dual-Polarized Transparent Antenna and Its Application for Capsule Endoscopy System
Authors: Lin Yu-Ming , Wu Hung-Wei , Hung Cheng-Yuan , Chang Shoou-Jinn , Liu Ran
Published: July 2023

In this paper, we proposed a small transparent thin film antenna for a wireless capsule endoscopy system. The transparent thin film antenna is needed to provide a clear 360° broad-sight view of the wireless capsule system in the future. Furthermore, the transparent thin film is critical for performing the dual-polarized antenna operating at 2.45 GHz. The proposed transparent thin film uses the nano-alignment process to further achieve low resistivity from 3.78 × 10−4 Ω-cm to 9.14 × 10−5 Ω-cm and improves the transparency by over 70%. The nano-alignment process includes periodic electrodes with AC signals that can effectively rearrange the nano-material into an ordered arrangement, enhancing the thin film’s microwave characteristics. Due to applying to the capsule endoscopy system, the ability of water resistance is also considered in this design. Therefore, the O2 plasma treatment is used to improve the water contact angle from 76° to 31°, measured on the surface of the thin film. The proposed transparent antenna is designed to have a center frequency of 2.45 GHz, a bandwidth of 855 MHz, and an antenna gain of −26.3 dBi, and is helpful for capsule endoscopy systems.
An IoT System and MODIS Images Enable Smart Environmental Management for Mekong Delta
Authors: Phan Vu Hien , Pham Danh Phan Hong , Pham Tran Vu , Qureshi Kashif Naseer , Pham-Quoc Cuong
Published: July 2023

The smart environmental management system proposed in this work offers a new approach to environmental monitoring by utilizing data from IoT stations and MODIS satellite imagery. The system is designed to be deployed in vast regions, such as the Mekong Delta, with low building and operating costs, making it a cost-effective solution for environmental monitoring. The system leverages telemetry data collected by IoT stations in combination with MODIS MOD09GA, MOD11A1, and MCD19A2 daily image products to develop computational models that calculate the values land surface temperature (LST), 2.5 and 10 (µm) particulate matter mass concentrations (PM2.5 and PM10) in areas without IoT stations. The MOD09GA product provides land surface spectral reflectance from visible to shortwave infrared wavelengths to determine land cover types. The MOD11A1 product provides thermal infrared emission from the land surface to compute LST. The MCD19A2 product provides aerosol optical depth values to detect the presence of atmospheric aerosols, e.g., PM2.5 and PM10. The collected data, including remote sensing images and telemetry sensor data, are preprocessed to eliminate redundancy and stored in cloud storage services for further processing. This allows for automatic retrieval and computation of the data by the smart data processing engine, which is designed to process various data types including images and videos from cameras and drones. The calculated values are then made available through a graphic user interface (GUI) that can be accessed through both desktop and mobile devices. The GUI provides real-time visualization of the monitoring values, as well as alerts to administrators based on predetermined rules and values of the data. This allows administrators to easily monitor the system, configure the system by setting alerting rules or calibrating the ground stations, and take appropriate action in response to alerts. Experimental results from the implementation of the system in Dong Thap Province in the Mekong Delta show that the linear regression models for PM2.5 and PM10 estimations from MCD19A2 AOD values have correlation coefficients of 0.81 and 0.68, and RMSEs of 4.11 and 5.74 µg/m3, respectively. Computed LST values from MOD09GA and MOD11A1 reflectance and emission data have a correlation coefficient of 0.82 with ground measurements of air temperature. These errors are comparable to other models reported in similar regions in the literature, demonstrating the effectiveness and accuracy of the proposed system.
The Analytical Fractional Solutions for Coupled Fokas System in Fiber Optics Using Different Methods
Authors: Mohammed Wael W. , Cesarano Clemente , Elsayed Elsayed M. , Al-Askar Farah M.
Published: July 2023

The Fokas system with M-truncated derivative (FS-MTD) was considered in this study. To get analytical solutions of FS-MTD in the forms of elliptic, rational, hyperbolic, and trigonometric functions, we employed the extend F-expansion approach and the Jacobi elliptic function method. Since nonlinear pulse transmission in monomode optical fibers is explained by the Fokas system, the derived solutions may be utilized to analyze a broad range of important physical processes. In order to comprehend the impacts of MTD on the solutions, the dynamic behavior of the various generated solutions are shown using 2D and 3D figures.
Effect of Er:YAG Laser Exposure on the Amorphous Smear Layer in the Marginal Zone of the Osteotomy Site for Placement of Dental Screw Implants: A Histomorphological Study
Authors: Kanazirski Nikolay , Vladova Diyana , Neychev Deyan , Raycheva Ralitsa , Kanazirska Petya
Published: July 2023

The placement of dental screw implants typically involves the use of rotary techniques and drills to create a bone bed. This study explores the potential benefits of combining this method with an Er:YAG laser. Split osteotomies were performed on 10 jaws of euthanized domestic pigs (Sus scrofa domestica), with 12 mandibular implant osteotomies in each jaw, divided into 4 groups. In order to make a comprehensive assessment of the effect of Er:YAG lasers, histomorphological techniques were used to measure the reduction in amorphous layer thickness after Er:YAG laser treatment, both with and without the placement of dental screw implants from different manufacturers. Following bone decalcification and staining, the thickness of the amorphous layer was measured in four groups: Group A—osteotomy performed without Er:YAG laser treatment—had amorphous layer thicknesses ranging from 21.813 to 222.13 µm; Group B—osteotomy performed with Er:YAG laser treatment—had amorphous layer thicknesses ranging from 6.08 to 64.64 µm; Group C—an implant placed in the bone without laser treatment—had amorphous layer thicknesses of 5.90 to 54.52 µm; and Group D—an implant placed after bone treatment with Er:YAG laser—had amorphous layer thicknesses of 1.29 to 7.98 µm. The examination and photomicrodocumentation was performed using a LEICA DM1000 LED microscope (Germany) and LAS V 4.8 software (Leica Application Suite V4, Leica Microsystems, Germany). When comparing group A to group B and group C to D, statistically significant differences were indicated (p-value = 0.000, p < 0.05). The study demonstrates the synergistic effects and the possibility of integrating lasers into the conventional implantation protocol. By applying our own method of biomodification, the smear layer formed during rotary osteotomy can be reduced using Er:YAG lasers. This reduction leads to a narrower peri-implant space and improved bone-to-implant contact, facilitating accelerated osseointegration.
Glissonean Pedicle Isolation Focusing on the Laennec’s Capsule for Minimally Invasive Anatomical Liver Resection
Authors: Morimoto Mamoru , Matsuo Yoichi , Nonoyama Keisuke , Denda Yuki , Murase Hiromichi , Kato Tomokatsu , Imafuji Hiroyuki , Saito Kenta , Takiguchi Shuji
Published: July 2023

Background: Inflow control is one of the most important procedures during anatomical liver resection (ALR), and Glissonean pedicle isolation (GPI) is one of the most efficacious methods used in laparoscopic anatomical liver resection (LALR). Recognition of the Laennec’s capsule covering the liver parenchyma is essential for safe and precise GPI. The purpose of this study was to verify identification of the Laennec’s capsule, to confirm the validity of GPI in minimally invasive surgery, and to demonstrate the value of GPI focusing on the Laennec’s capsule using a robotic system that has been developed in recent years. Methods: We used a cadaveric model to simulate the Glissonean pedicle and the surrounding liver parenchyma for pathologic verification of the layers. We performed 60 LALRs and 39 robotic anatomical liver resections (RALRs) using an extrahepatic Glissonean approach, from April 2020 to April 2023, and verified the layers of the specimens removed during LALR and RALR based on pathologic examination. In addition, the surgical outcomes of LALR and RALR were compared. Results: Histologic examination facilitated by Elastica van Gieson staining revealed the presence of Laennec’s capsule covering the liver parenchyma in a cadaveric model. Similar findings were obtained following LALR and RALR, thus confirming that the gap between the Glissonean pedicle and the Laennec’s capsule can be dissected without injury to the parenchyma. The mean GPI time was 32.9 and 27.2 min in LALR and RALR, respectively. The mean blood loss was 289.7 and 131.6 mL in LALR and RALR, respectively. There was no significant difference in the incidence of Clavien–Dindo grade ≥III complications between the two groups. Conclusions: Laennec’s capsule is the most important anatomical landmark in performing a safe and successful extrahepatic GPI. Based on this concept, it is possible for LALR and RALR to develop GPI focusing on the Laennec’s capsule. Furthermore, a robotic system has the potential to increase the safety and decrease the difficulty of this challenging procedure.
Ultrasound as a Method for Early Diagnosis of Breast Pathology
Authors: Santos Rute , Ribeiro Ana Raquel , Marques Daniela
Published: July 2023

Introduction: Ultrasound is a non-invasive, low-cost technique that does not use ionising radiation and provides a “real-time” image, and for these reasons, this method is ideal in several situations. Purpose: To demonstrate breast ultrasound evaluation as a first-line diagnostic method and to evaluate the variation of breast characteristics with age. Material and Methods: A total of 105 women with a mean age of 30 years participated and were divided into three age groups: 18–39, 40–59, and 60–79 years, excluding participants subject to mastectomy. After completing the informed consent, all participants answered personal and sociodemographic questions, such as personal and family history, menstrual cycle, pregnancy, ultrasound, and mammography, among others. They were then submitted to a bilateral breast ultrasound examination. Subsequently, all the images and their data were analysed, and a technical report of the examination was given to all the participants. Results: A total of 105 women with a mean age of 30 years participated, 58 of whom underwent the examination for the first time. In 31, changes (of which only 7 were known) were diagnosed. It was verified that, according to age group, the density of the breast stroma varied; older women have less breast density. Conclusions: Ultrasound is a good method for breast evaluation and can be considered important for the early evaluation of breast pathology and follow-up of the pathology.
Recent Developments in Two-Dimensional Materials-Based Membranes for Oil–Water Separation
Authors: Ezazi Mohammadamin , Quazi M. M.
Published: July 2023

The industrialization witnessed in the last century has resulted in an unprecedented increase in water pollution. In particular, the water pollution induced by oil contaminants from oil spill accidents, as well as discharges from pharmaceutical, oil/gas, and metal processing industries, have raised concerns due to their potential to pose irreversible threats to the ecosystems. Therefore, the effective treating of these large volumes of oily wastewater is an inevitable challenge to address. Separating oil–water mixtures by membranes has been an attractive technology due to the high oil removal efficiency and low energy consumption. However, conventional oil–water separation membranes may not meet the complex requirements for the sustainable treatment of wastewater due to their relatively shorter life cycle, lower chemical and thermal stability, and permeability/selectivity trade-off. Recent advancements in two-dimensional (2D) materials have provided opportunities to address these challenges. In this article, we provide a brief review of the most recent advancements in oil–water separation membranes modified with 2D materials, with a focus on MXenes, graphenes, metal–organic frameworks, and covalent organic frameworks. The review briefly covers the backgrounds, concepts, fabrication methods, and the most recent representative studies. Finally, the review concludes by describing the challenges and future research directions.
Electroslag Hollow Ingots for Nuclear and Petrochemical Pressure Vessels and Pipes
Authors: Medovar Lev , Stovpchenko Ganna , Sybir Artem , Gao Jianjun , Ren Liguo , Kolomiets Dmytro
Published: July 2023

The paper presents ground reasoning and results of experiments and modeling of heavy hollow ingot manufacturing using advanced electroslag technology. The requirements for ingots for huge diameter reactor pressure vessels include high density, homogeneity, and minimal segregation, which are very difficult to achieve by traditional casting. In the electroslag remelting process (ESR), hollow ingots form in between two copper water-cooled molds under effective heat removal. This improves the solidification pattern due to the shortening of a solidifying volume thickness more than twice compared with a solid ingot of the same diameter. The shallow liquid metal pool and narrow mushy zone at the ESR hollow ingot solidification assure their high metallurgical quality. Due to the dense and low segregation structure, ESR hollow ingots proved to be used for as-cast pipes and heavy wall billets for further forging. The results of a mathematical simulation within the range of simulated dimensions (the outer diameter up to 2900 mm, wall thickness up to 750 mm) also predict the favorable solidification pattern for thick-wall hollow ingots of big diameters. The analysis made and the modeling results provide a framework for scaling up the sizes of hollow ingots produced by ESR and widening their application for manufacturing heavy wall large diameter shells for nuclear and petrochemical industries. The higher reachable productivity of hollow ingot formation and lower capacity of power supply source than that for solid ingots of the same diameter and weight are also preconditions of their energy saving and cost-effective manufacturing.
Highly Sensitive Voltammetric Method for Quinoline Yellow Determination on Renewable Amalgam Film Electrode
Authors: Górska-Ratusznik Anna , Różańska Dominika , Smajdor Joanna , Paczosa-Bator Beata , Piech Robert
Published: July 2023

A novel electrochemical method for the determination of quinoline yellow (QY) was developed using the renewable amalgam film electrode (Hg(Ag)FE). The sensors used can be characterized by good stability and long lifespan. Irreversible QY reduction peaks were recorded in 0.05 mol L−1 HCl with a potential of about −630 mV. The use of the Hg(Ag)FE electrode with a regulated working surface allowed the QY limit of detection to be as low as 0.48 nmol L−1. The obtained result is the lowest in comparison to other voltammetric methods described in the literature. The effects of parameters such as the size of the working electrode surface, influence of the pH value, accumulation time, and potential were investigated to provide precision and high sensitivity of the performed measurements. This new procedure was applied for the highly sensitive determination of quinoline yellow in different beverages, pre-workout supplements, and throat lozenges. The process of sample preparation was relatively simple. Calculated recoveries (96–107%) suggest that the method can be considered accurate.
Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX Inhibitors
Authors: Mikus Jakub , Świątek Piotr , Przybyła Patrycja , Krzyżak Edward , Marciniak Aleksandra , Kotynia Aleksadra , Redzicka Aleksandra , Wiatrak Benita , Jawień Paulina , Gębarowski Tomasz , Szczukowski Łukasz
Published: July 2023

Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-d]pyridazinone are potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam. Considering that N-acylhydrazone (NAH) moiety is a privileged structure occurring in many promising drug candidates, we decided to introduce this pharmacophore into new series of pyrrolo[3,4-d]pyridazinone derivatives. The current paper presents the synthesis and in vitro, spectroscopic, and in silico studies evaluating the biological and physicochemical properties of NAH derivatives of pyrrolo[3,4-d]pyridazinone. Novel compounds 5a-c–7a-c were received with high purity and good yields and did not show cytotoxicity in the MTT assay. Their COX-1, COX-2, and 15-LOX inhibitory activities were estimated using enzymatic tests and molecular docking studies. The title N-acylhydrazones appeared to be promising dual COX/LOX inhibitors. Moreover, spectroscopic and computational methods revealed that new compounds form stable complexes with the most abundant plasma proteins–AAG and HSA, but do not destabilize their secondary structure. Additionally, predicted pharmacokinetic and drug-likeness properties of investigated molecules suggest their potentially good membrane permeability and satisfactory bioavailability.
Phytochemicals from Anneslea fragrans Wall. and Their Hepatoprotective and Anti-Inflammatory Activities
Authors: Wang Yan , Cheng Changshu , Zhao Tianrui , Cao Jianxin , Liu Yaping , Wang Yudan , Zhou Wenbing , Cheng Guiguang
Published: July 2023

Anneslea fragrans Wall., popularly known as “Pangpo tea”, is an edible, medicinal, and ornamental plant of the Family Theaceae. The leaves of A. fragrans were historically applied for the treatment of liver and intestinal inflammatory diseases in China. This study aimed to explore the hepatoprotective agents from A. fragrans leaves through hepatoprotective and anti-inflammatory assessment. The phytochemical investigation of the leaves of A. fragrans resulted in the isolation and identification of a total of 18 chemical compounds, including triterpenoids, aliphatic alcohol, dihydrochalcones, chalcones, flavanols, phenolic glycoside, and lignans. Compounds 1–2, 4–6, 11–12, and 16–18 were identified from A. fragrans for the first time. Compounds 7 and 14 could significantly alleviate hepatocellular damage by decreasing the contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and inhibit the hepatocellular apoptosis in the HepG2 cells induced by N-acetyl-p-aminophenol (APAP). In addition, compounds 7 and 14 inhibited reactive oxygen species (ROS) and malondialdehyde (MDA) contents and increased the catalase (CAT) superoxide dismutase (SOD), and glutathione (GSH) levels for suppressing APAP-induced oxidative stress. Additionally, compounds 7, 13, and 14 also had significant anti-inflammatory effects by inhibiting interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) productions on LPS-induced RAW246.7 cells.
The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System
Authors: Colin Mélissa , Delaitre Céline , Foulquier Sébastien , Dupuis François
Published: July 2023

The AT1 receptor has mainly been associated with the pathological effects of the renin-angiotensin system (RAS) (e.g., hypertension, heart and kidney diseases), and constitutes a major therapeutic target. In contrast, the AT2 receptor is presented as the protective arm of this RAS, and its targeting via specific agonists is mainly used to counteract the effects of the AT1 receptor. The discovery of a local RAS has highlighted the importance of the balance between AT1/AT2 receptors at the tissue level. Disruption of this balance is suggested to be detrimental. The fine tuning of this balance is not limited to the regulation of the level of expression of these two receptors. Other mechanisms still largely unexplored, such as S-nitrosation of the AT1 receptor, homo- and heterodimerization, and the use of AT1 receptor-biased agonists, may significantly contribute to and/or interfere with the settings of this AT1/AT2 equilibrium. This review will detail, through several examples (the brain, wound healing, and the cellular cycle), the importance of the functional balance between AT1 and AT2 receptors, and how new molecular pharmacological approaches may act on its regulation to open up new therapeutic perspectives.
Electrochemical Determination of Epinephrine in Pharmaceutical Preparation Using Laponite Clay-Modified Graphene Inkjet-Printed Electrode
Authors: Pecheu Chancellin , Tchieda Victor , Tajeu Kevin , Jiokeng Sherman , Lesch Andreas , Tonle Ignas , Ngameni Emmanuel , Janiak Christoph
Published: July 2023

Epinephrine (EP, also called adrenaline) is a compound belonging to the catecholamine neurotransmitter family. It can cause neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. This work describes an amperometric sensor for the electroanalytical detection of EP by using an inkjet-printed graphene electrode (IPGE) that has been chemically modified by a thin layer of a laponite (La) clay mineral. The ion exchange properties and permeability of the chemically modified electrode (denoted La/IPGE) were evaluated using multi-sweep cyclic voltammetry, while its charge transfer resistance was determined by electrochemical impedance spectroscopy. The results showed that La/IPGE exhibited higher sensitivity to EP compared to the bare IPGE. The developed sensor was directly applied for the determination of EP in aqueous solution using differential pulse voltammetry. Under optimized conditions, a linear calibration graph was obtained in the concentration range between 0.8 µM and 10 μM. The anodic peak current of EP was directly proportional to its concentration, leading to detection limits of 0.34 μM and 0.26 μM with bare IPGE and La/IPGE, respectively. The sensor was successfully applied for the determination of EP in pharmaceutical preparations. Recovery rates and the effects of interfering species on the detection of EP were evaluated to highlight the selectivity of the elaborated sensor.
The Selective Separation of Carnosic Acid and Rosmarinic Acid by Solid-Phase Extraction and Liquid–Liquid Extraction: A Comparative Study
Authors: Zhu Chunyan , Fan Yunchang , Wu Hongwei
Published: July 2023

Rosmarinus officinalis leaves (ROLs) are widely used in the food and cosmetics industries due to their high antioxidant activity and fascinating flavor properties. Carnosic acid (CA) and rosmarinic acid (RA) are regarded as the characteristic antioxidant components of ROLs, and the selective separation of CA and RA remains a significant challenge. In this work, the feasibility of achieving the selective separation of CA and RA from ROLs by solid-phase extraction (SPE) and liquid–liquid extraction (LLE) was studied and compared. The experiments suggested that SPE with CAD-40 macroporous resin as the adsorbent was a good choice for selectively isolating CA from the extracts of ROLs and could produce raw CA with purity levels as high as 76.5%. The LLE with ethyl acetate (EA) as the extraction solvent was more suitable for extracting RA from the diluted extracts of ROLs and could produce raw RA with a purity level of 56.3%. Compared with the reported column chromatography and LLE techniques, the developed SPE–LLE method not only exhibited higher extraction efficiency for CA and RA, but can also produce CA and RA with higher purity.
Apple Pomace Compositional Data Highlighting the Proportional Contribution of Polymeric Procyanidins
Authors: Bindon Keren , Qi Song , Kassara Stella , Nicolotti Luca , Jouin Alicia , Beer Maggie
Published: July 2023

Recent years have seen an increase in research focusing on the amelioration of apple pomace waste for use in the food and nutraceutical industries. Much of this work has concentrated on the characterisation of the polyphenol composition of apple pomace materials to determine their role in conferring nutritional and health benefits. Although apples contain substantial quantities of polymeric procyanidins (condensed tannins), this class of compounds has received limited attention in apple research. This study quantified the polymeric procyanidins in apple pomace extracts using a rapid, methyl-cellulose precipitation (MCP) approach for the first time. In addition, a non-targeted metabolomics approach was applied to determine the most abundant phenolic classes present. Polymeric procyanidins were found to be the most abundant type of polyphenol in apple pomace extracts and were generally oligomeric in nature. Multivariate statistical analysis revealed that the ferric-reducing antioxidant power (FRAP) was most strongly correlated with the polymeric procyanidin concentration. Noting that polymeric procyanidins may not cross the cell layer to exert antioxidant activity in vivo, their presence in apple pomace extracts may therefore overestimate the FRAP. This work highlights the importance of polymeric procyanidins in the phenolic diversity of apple pomaces, and it is proposed that in future studies, rapid MCP assays may be used for their quantification.
Natural Rigid and Hard Plastic Fabricated from Elastomeric Degradation of Natural Rubber Composite with Ultra-High Magnesium Carbonate Content
Authors: Dasaesamoh Abedeen , Khotmungkhun Kittikhun , Subannajui Kittitat
Published: July 2023

It is known that natural rubber is an elastomeric polymer; hence, the main uses are usually limited to soft applications. For the process to reverse the elastomeric effect of natural rubber to obtain rigid plastic from a natural material, an ultra-high amount of magnesium carbonate particles was added to the natural rubber to study the effect of magnesium carbonate in the reduction of elastomeric properties. High magnesium carbonate ratios of 80–180 phr were mixed in the natural rubber in the latex form to maximize the mixing capability since it was more difficult to achieve these mixture ratios with only two roll mill or extruder processes. The more magnesium carbonate powders in the composite, the higher torques were measured from the moving die rheometer (MDR) test. The powder was thoroughly mixed inside the composite, which was observed from energy-dispersive X-ray spectrometer (EDX) mapping; however, the matrix of composites was filled with porosity due to the CO2 formation when latex with magnesium carbonate was assimilated with acid during the vulcanization process. The strength of the composite dropped, and the elongations were shortened. On the other hand, the hardness of composites was drastically increased. The composite lost the elastomeric property, and the hard natural rubber composites were obtained.
The Effect of Porosity on the Thermal Conductivity of Highly Thermally Conductive Adhesives for Advanced Semiconductor Packages
Authors: Choi Hyun-Seok , Park Jeong-Hyun , Lee Jong-Hee
Published: July 2023

This study suggests promising candidates as highly thermally conductive adhesives for advanced semiconductor packaging processes such as flip chip ball grid array (fcBGA), flip chip chip scale package (fcCSP), and package on package (PoP). To achieve an extremely high thermal conductivity (TC) of thermally conductive adhesives of around 10 Wm−1K−1, several technical methods have been tried. However, there are few ways to achieve such a high TC value except by using spherical aluminum nitride (AlN) and 99.99% purified aluminum oxide (Al2O3) fillers. Herein, by adapting highly sophisticated blending and dispersion techniques with spherical AlN fillers, the highest TC of 9.83 Wm−1K−1 was achieved. However, there were big differences between theoretically calculated TCs that were based on the conventional Bruggeman asymmetric model and experimentally measured TCs due to the presence of voids or pores in the composites. To narrow the gaps between these two TC values, this study also suggests a new experimental model that contains the porosity effect on the effective TC of composites in high filler loading ranges over 80 vol%, which modifies the conventional Bruggeman asymmetric model.
Chitosan Oligomer as a Raw Material for Obtaining Polyurethane Foams
Authors: Strzałka Anna , Lubczak Renata , Lubczak Jacek
Published: July 2023

Decreasing oil extraction stimulates attempts to use biologically available sources to produce polyols, which are the basic components for obtaining polyurethane foams. Plants are inexhaustible source of oils, sugars, starches, and cellulose. Similar substrates to obtain polyols are chitosans. Commercially available modified chitosans are soluble in water, which gives them the possibility to react with hydroxyalkylating agents. We used a water-soluble chitosan previously to obtain polyols suitable for producing rigid polyurethane foams. Here, we described hydroxyalkylation of a low-molecular-weight chitosan (oligomeric chitosan) with glycidol and ethylene carbonate to obtain polyols. The polyols were isolated and studied in detail by IR, 1H-NMR, and MALDI–ToF methods. Their properties, such as density, viscosity, surface tension, and hydroxyl numbers, were determined. The progress of the hydroxyalkylation reaction of water-soluble chitosan and chitosan oligomer with glycidol was compared in order to characterize the reactivity and mechanism of the process. We found that the hydroxyalkylation of chitosan with glycidol in glycerol resulted in the formation of a multifunctional product suitable for further conversion to polyurethane foams with favorable properties. The straightforward hydroxyalkylation of chitosan with glycidol was accompanied by the oligomerization of glycidol. The hydroxyalkylation of chitosan with glycidol in the presence of ethylene carbonate was accompanied by minor hydroxyalkylation of chitosan with ethylene carbonate. The chosen polyols were used to obtain rigid polyurethane foams which were characterized by physical parameters such as apparent density, water uptake, dimension stability, heat conductance, compressive strength, and heat resistance at 150 and 175 °C. The properties of polyurethane foams obtained from chitosan-oligomer and water-soluble-chitosan sources were compared. Polyurethane foams obtained from polyols synthesized in the presence of glycerol had advantageous properties such as low thermal conductivity, enhanced thermal resistance, dimensional stability, low water uptake, and high compressive strength, growing remarkably upon thermal exposure.
The Multifaceted Reception of the Torah by Early Church Fathers
Authors: Attard Stefan M.
Published: July 2023

This paper focuses on the reception of the Torah by the Church Fathers who lived up to the beginning of the third century. Christians, having received the whole Torah through the Septuagint translation, became selective in the way they accepted it, adhering to it only with reservations. Christological and ethical concerns were at the heart of their acceptance or rejection of various aspects of the Torah. This article will gauge whether Christians had a positive, negative, or neutral evaluation of the Torah and will seek to identify the ways in which they perceived the Torah. By analysing the ways in which the Torah and at times other Old Testament texts were handled, their presentation of these Jewish Scriptures will be brought to light, highlighting different approaches employed in this regard. One notes the following stances: the Torah’s commandments supplemented the Lord’s teachings (the Didache); the Torah was read allegorically and typologically despite a Midrashic approach (Epistle of Barnabas); certain laws were believed to have been instituted as a result of the people’s hardness of heart (Justin Martyr); natural law is distinct from the demands added to it after the Jews’ wayward actions (Irenaeus); the temporal aspects of the law were superseded by its eternal aspects (Tertullian); whilst upholding the promises of the Law, the prophets were seen as going beyond the Law (Tertullian) or as giving the Law a spiritual interpretation (Epistle of Barnabas); and, rarely, the Law was held in very high regard (Clement of Alexandria). This paper is not concerned with any blatant rejection of the Torah and, indeed, the Tanakh at large (as was the case with Marcion), but rather with the subtler nuances that can be detected in other writers who had to rethink the validity and role/place of the Torah in the faith.
Christianity Cultivated Science with and without Methodological Naturalism
Authors: Keas Michael N.
Published: July 2023

Many people assume ceaseless conflict between natural science and Christianity, but the real conflict has been between scientism and Christianity. Scientism is the view that only the sciences (especially not theology) generate knowledge or rational belief. I show how Christianity generated rational beliefs that contributed to the rise of science. This science-fostering rational belief included rationales for when to practice methodological naturalism, and when to study nature without that restriction. Both practices cultivated science, though in different ways. This historical difference is of enduring value for recent debates about metaphysical naturalism (atheism), creationism, theistic evolution, and intelligent design.
The Effect of Aerobic and Resistance Exercise after Bariatric Surgery: A Systematic Review
Authors: Ekici Ece , Özden Fatih , Özkeskin Mehmet
Published: July 2023

Understanding the optimal time, length, intensity, and type of exercise program for bariatric surgery patients is crucial due to increased obesity prevalence and the number of performed bariatric procedures. Our aim for this review is to identify the effects of exercise on all aspects of health regarding the most recent and randomized studies. A total of 120 articles were reviewed through PubMed. As a result of the research, 11 studies that met the inclusion criteria were included. A quality analysis and a risk of bias assessment of the trials included in this systematic review were performed using the Physiotherapy Evidence Database (PEDro) scoring and classification system. Narrative syntheses were given for this systematic review. The articles’ intervention description, outcomes, and results are given in detail in the Results Section. Most exercise interventions were carried out in the post-op stage in bariatric surgery patients. Only two studies were conducted before the scheduled procedure. Overall, aerobic training (AT) and resistance training (RT) combined exercise programs effectively improved clinical parameters, including cardiac function, lower extremity function, muscle strength and endurance, cardiovascular parameters, and functionality. Exercise training caused no additional effects on inflammation and endothelial dysfunction biomarkers. In the literature, no research identifies the effects of only AT on bariatric surgery patients. Therefore, this aspect should be considered when interpreting all the studies’ results. In conclusion, there is a need for research to examine only AT in bariatric surgery patients and for general exercise training studies, including better randomization and quality.
Prevenção de infecções por microrganismos multirresistentes em serviços de saúde: uma revisão de literatura
Authors: Mendonça Lara Ohanna Arantes , Caldas Erika Rodrigues , Rosa Sophia Antunes , Leles Ana Cristina Rodrigues , Paresoto Luiza Martins , Cunha Raíssa Rosa , Vieira Filho Fabiano Marques , Zanol Thiago Sales , Silva Gabriela Falone , Dornelles Eliaquim Almeida , Ferreira Maíra Valle , Marcelino Elisangela da Costa , Caixeta Flávia de Castro , Balduino Tomaz Lamounier Paes
Published: July 2023

As Infecções Relacionadas à Assistência à Saúde (IRAS) são tidas como um problema de saúde pública em que a adoção de medidas preventivas pode ajudar a controlar/minimizar a morbimortalidade dos usuários do sistema de saúde. A instituição hospitalar precoce de isolamento de contato para os usuários que estão possivelmente colonizados por microrganismos multirresistentes (MR), pode diminuir sua disseminação os casos de IRAS, o que melhora a assistência prestada, assim como, ameniza os custos hospitalares. Objetivo: identificar com base na literatura quais são as medidas de prevenção de infecções por MR que devem ser adotadas em serviços de saúde. Metodologia: Revisão de literatura com fontes de pesquisa online. A busca foi realizada na base de dados bibliográficos Journal Of Infection Control, REBIS, LILACS e SciELO. Foram adotados os critérios de inclusão: disponíveis na íntegra em plataformas digitais, publicados no período de 5 anos (2018 a 2022), em língua vernácula (português) e estrangeiras (inglês e espanhol), como temática central resistencia antimicrobiana. Os critérios de exclusão adotados foram: literatura cinzenta artigos que não possuíam resumo para análise, estudos duplicados. Resultados e Discussão: foram incluídos 13 estudos na presente revisão, em todos os estudos foram encontradas explicações sobre a prevenção de infecções discute acerca das medidas preventivas para MR em serviços de saúde. Considerações Finais: As medidas de prevenção de infecções por MR que devem ser adotadas em serviços de saúde consistem nos profissionais adotarem as medidas de higiene estabelecidas pela CCIH das instituições hospitalares, e que eles também sejam conscientizados a respeito da importância de prevenção das IRAS.
Assédio sexual na caserna: um crime silencioso
Authors: Ferreira Gisleia Aparecida
Published: July 2023

O crime de assédio sexual foi tipificado na legislação penal brasileira em 2001, criminalizando esta prática abusiva tão comum e banalizada em tempos anteriores. O assédio sexual, infelizmente, é uma prática cultural, que envolve a honra das mulheres, e que muitas vezes não é exposto para outras pessoas, muito menos denunciado como crime. O objetivo do presente estudo foi relatar situações de assédio sexual no ambiente  militar, e as consequências destes atos. A metodologia utilizada foi a pesquisa bibliográfica e jurisprudencial, com apoio do google acadêmico  bem como buscas em sites de jurisprudências sobre o tema. Após estas buscas, houve análise qualitativa dos casos encontrados, e ao final foi apresentado um caso envolvendo um oficial da Polícia Militar do Paraná, cujo julgamento gerou repercussão nacional. Questionou-se: mesmo na atualidade, com inúmeros direitos sendo protegidos legalmente, casos de assédio sexual podem ficar impunes? Existem diferenciações entre assédio sexual no meio militar e assédio sexual em ambiente de trabalho civil? Observadas várias jurisprudências a respeito do tema, concluindo-se que a vítima tem que estar muito forte psicologicamente e ter respaldo da instituição para denunciar casos de assédio sexual, pois haverá certamente revitimização contra ela, bem como outras consequências, devido ao machismo estrutural e relações hierárquicas militares, dificultando punições exemplares.
A finalidade da Zona Franca de Manaus e de seus incentivos
Authors: De Souza Beatriz Lima , Mesquita Luana da Cruz , Luna Italo Bruno Araujo
Published: July 2023

O presente trabalho consiste em um estudo que tem objetivo geral demonstrar a finalidade da Zona Franca de Manaus (ZFM) e de seus incentivos, partindo do pressuposto de que a ZFM fora estabelecida em 1957 visando atrair empresas, mão de obra e maiores desenvolvimentos, por intermédio de subsídios fiscais, para a região Amazônica, em um Estado considerado desfavorecido pelo seu tamanho, logística e ausência de infraestrutura. A partir disso, o presente artigo propõe-se a discorrer sobre os desafios da ZFM, analisando a correlação entre seus incentivos e os impactos que suas vantagens financeiras expressam para a região norte do Brasil. Para tanto, utilizou-se pesquisa bibliográfica exploratória e análise qualitativa, a partir de pesquisa em fontes multidisciplinares, guiada por ideias e planejamentos relativos à ZFM. As conclusões apresentadas demonstram que, em que pese as ameaças que o modelo constantemente sofre, a ZFM é o modelo de desenvolvimento econômico mais bem-sucedido do país, além de ser o principal motor da economia local, gerando milhares de empregos diretos e indireto. O polo industrial é a base de sustentação dos regimes da ZFM e tem como consequência inequívoca movimentação positiva na economia brasileira.