bluuebunny/crossref_metadata_2025 huggingface dataset:
Electronic Health Records–Based Cardio-Oncology Registry for Care Gap Identification and Pragmatic Research: Procedure and Observational Study
Authors: Chandra Alvin , Philips Steven T , Pandey Ambarish , Basit Mujeeb , Kannan Vaishnavi , Sara Evan J , Das Sandeep R , Lee Simon J C , Haley Barbara , Willett DuWayne L , Zaha Vlad G
Published: March 2021

Background

Professional society guidelines are emerging for cardiovascular care in cancer patients. However, it is not yet clear how effectively the cancer survivor population is screened and treated for cardiomyopathy in contemporary clinical practice. As electronic health records (EHRs) are now widely used in clinical practice, we tested the hypothesis that an EHR-based cardio-oncology registry can address these questions.

Objective

The aim of this study was to develop an EHR-based pragmatic cardio-oncology registry and, as proof of principle, to investigate care gaps in the cardiovascular care of cancer patients.

Methods

We generated a programmatically deidentified, real-time EHR-based cardio-oncology registry from all patients in our institutional Cancer Population Registry (N=8275, 2011-2017). We investigated: (1) left ventricular ejection fraction (LVEF) assessment before and after treatment with potentially cardiotoxic agents; and (2) guideline-directed medical therapy (GDMT) for left ventricular dysfunction (LVD), defined as LVEF<50%, and symptomatic heart failure with reduced LVEF (HFrEF), defined as LVEF<50% and Problem List documentation of systolic congestive heart failure or dilated cardiomyopathy.

Results

Rapid development of an EHR-based cardio-oncology registry was feasible. Identification of tests and outcomes was similar using the EHR-based cardio-oncology registry and manual chart abstraction (100% sensitivity and 83% specificity for LVD). LVEF was documented prior to initiation of cancer therapy in 19.8% of patients. Prevalence of postchemotherapy LVD and HFrEF was relatively low (9.4% and 2.5%, respectively). Among patients with postchemotherapy LVD or HFrEF, those referred to cardiology had a significantly higher prescription rate of a GDMT.

Conclusions

EHR data can efficiently populate a real-time, pragmatic cardio-oncology registry as a byproduct of clinical care for health care delivery investigations.
Effort-Optimized Intervention Model: Framework for Building and Analyzing Digital Interventions That Require Minimal Effort for Health-Related Gains
Authors: Baumel Amit , Muench Frederick J
Published: March 2021

The majority of digital health interventions lean on the promise of bringing health and self-care into people’s homes and hands. However, these interventions are delivered while people are in their triggering environments, which places competing demands on their attention. Individuals struggling to change or learn a new behavior have to work hard to achieve even a minor change because of the automatic forces propelling them back to their habitual behaviors. We posit that effort and burden should be explored at the outset and throughout the digital intervention development process as a core therapeutic mechanism, beyond the context of design or user experience testing. In effort-focused conceptualization, it is assumed that, even though goals are rational and people want to achieve them, they are overtaken by competing cognitive, emotional, and environmental processes. We offer the term effort-optimized intervention to describe interventions that focus on user engagement in the face of competing demands. We describe design components based on a 3-step process for planning an effort-optimized intervention: (1) nurturing effortless cognitive and environmental salience to help people keep effort-related goals prominent despite competition; (2) making it as effortless as possible to complete therapeutic activities to avoid ego depletion and self-efficacy reduction; and (3) turning the necessary effortful activities into sustainable assets. We conclude by presenting an example of designing a digital health intervention based on the effort-optimized intervention model.
Effectiveness of clinical Pilates and home exercises in sagittal cervical disorientation: randomized controlled study
Authors: Hürer Cemaliye , Angın Ender , Tüzün Emine Handan
Published: March 2021

Aim:
 To compare effects of clinical Pilates and home exercises on postural disorders, strength and endurance of deep cervical flexors (DCF), cervical range of motion (CROM), pain intensity and functional disability in sagittal cervical disorientation.
Patients & methods
: Fourty six patients were included and divided into two groups. Clinical Pilates group performed stabilization based exercise and home exercise group performed conventional exercises.
Results:
Craniovertebral, head tilt, cervicothoracic angles and strength and endurance of DCF muscles had improvement in favor of clinical Pilates group (p < 0.05). There was no difference between groups in terms of right–left acromial distance, pain intensity, functional disability and CROM parameters (p > 0.05).
Conclusion:
Clinical Pilates exercises have been found to provide clinically significant improvements in craniovertebral, head tilt, cervicothoracic angles and strength and endurance of DCF muscles. However, in the increase of CROM, decreasing pain severity and functional impairment parameters there was no superiority of both exercise training.

Clinical trial registration number:
NCT03352921
 (Clinicaltrials.gov).
A comparative cost analysis between two quick diagnosis units of different levels of complexity
Authors: Bosch Xavier , Montori Elisabet , Merino-Peñas Maria J , Compta Yaroslau , Ladino Andrea , Ramon Jordi , López-Soto Alfonso
Published: March 2021

Aim:To compare by micro-costing the costs incurred by quick diagnosis units of tertiary and second-level hospitals.Patients & methods:We included 407 patients from a tertiary and secondary hospital unit. A bottom-up approach was applied.Results:Cost per patient was €577.5 ± 219.6 in the tertiary versus €394.7 ± 92.58 in the secondary unit (p = 0.0559). Mean number of visits and ratio of successive/first visits were significantly higher in the former (3.098 and 2.07 vs 2.123 and 1.12, respectively). Personnel and indirect costs including their percent contribution to overall costs accounted for the main differences.Conclusion:A greater volume of appointments, number of staff and staff time and a greater complexity of patients from the tertiary hospital unit justified the differences in cost outcomes.
Perfil ético del docente universitario desde la valoración de estudiantes de educación
Authors: Ventura Sosa Pedro Emilio
Published: March 2021

Este estudio, de tipo interpretativo y diseño cualitativo, se propuso comprender, desde la valoración de un grupo de estudiantes de la carrera de Educación, los rasgos que reconocen importantes en el perfil ético de un docente universitario e interpretar las actuaciones que consideran éticas y antiéticas. Fueron sistematizados los registros de opiniones de 39 estudiantes, a través de foros virtuales, un grupo focal y las anotaciones en un registro anecdótico del docente-investigador. El análisis de la información recabada se realizó a partir de categorías emergentes surgidas de los argumentos de los estudiantes. Los resultados destacan como rasgos positivos del perfil ético de un docente universitario: puntualidad, cordialidad, buen trato, coherencia entre el decir y hacer, justicia, solidaridad, democracia y actualización. Los rasgos no deseados incluyeron: responder groseramente, mostrar preferencias, mentir y hacer insinuaciones amorosas. El estudio permitió describir actuaciones éticas de impacto positivo que afianzarían el perfil docente deseable para su formación.
Aspectos históricos del teorema fundamental del cálculo y posibles mediaciones tecnológicas
Authors: Muñoz Villate Weimar
Published: March 2021

Este artículo presenta aspectos históricos del Teorema Fundamental del Cálculo (TFC) que podrían ser mediados por herramientas tecnológicas. Esta exploración pretende identificar en los argumentos de Newton y de Leibniz, un potencial heurístico para ser incorporados en ambientes de aprendizaje del cálculo en las universidades. Se presentan los resultados de una exploración de actualización de los argumentos de Newton y de Leibniz con la mediación del software matemático Geogebra. Los resultados de esta exploración articulan factores históricos y tecnológicos del TFC, que podrían usarse de manera curricular, por ejemplo, en el diseño de tareas para la formación universitaria.
Trabajo grupal y logro académico en un ambiente virtual de aprendizaje
Authors: Moreno-Salamanca Maria Carolina
Published: March 2021

El presente artículo contiene los resultados de un estudio de caso, que caracteriza el trabajo de un grupo de estudiantes con logros académicos sobresalientes de la unidad de estudio de geopolítica, correspondiente a un programa de pregrado en modalidad virtual, de una universidad privada localizada en Bogotá, Colombia. El objetivo del estudio fue documentar minuciosamente las formas de trabajo, que permitieran explicar sus altos niveles de desempeño y así establecer los criterios que favorezcan la integración de grupos futuros en ambientes virtuales de aprendizaje. Los criterios de selección del grupo observado fueron los excelentes resultados académicos que obtuvieron y sus altos niveles de motivación frente al grupo. La metodología utilizada fue cualitativa; se realizaron entrevistas individuales semi-estructuradas a cada uno de los integrantes y un grupo focal. Dentro de los principales hallazgos del estudio se encuentran las formas de organización del grupo y las estrategias de trabajo colaborativo.
Barrel Organ and Organ- Grinder in Russian Fiction of the 1840s
Authors: Sorokina Svetlana P.
Published: March 2021

In the 1840s, barrel organ and organ grinders became a core part of the city’s folk entertainment culture as mentioned in essayistic and memoir literature. However, the references are scarce and there are no detailed descriptions existing. To study this phenomenon of folk culture, the author turns to fictional texts: Dead Souls by N.V. Gogol, “Shtoss” by M. Yu. Lermontov, “Katerina-Hurdy-Gurdy” by I.P. Myatlev, and “Savvushka” by I.T. Kokorev. The article analyzes the chain of ideas that each of these authors associates with the barrel organ and organ-grinders. In general, these views correlate with the views reflected in non-literary sources. I.T. Kokorev develops the story of the street artist in the most detailed way which may be explained by his interests in essay writing, closeness to the so-called “natural school” (a 19 th century literary trend), and personal experience.
Daniil Kharms in China
Authors: Yu Gao
Published: March 2021

Daniil Kharms — a distinguished representative of the post-revolutionary avant- garde — was rediscovered in Russia in the 1990s. Chinese scholars began the study of his literary heritage in 2010 after a number of Kharms’ works had been translated into Chinese. Today, Kharms studies have become one of the most relevant trends within Chinese Slavic studies. This paper aims to examine Chinese interpretation of the core philosophical and aesthetic features of Kharms’ poetics in comparison with Russian scholarly interpretations and to analyze the mechanisms of reception of Kharms’s poetry and philosophy in China. Chinese scholars relate Kharms’ artistic techniques to the idea of the helplessness of a human being in the face of ontological problems. In general, Chinese scholars share an opinion that the originality of Kharms’ poetics meets the requirement of the new artistic style characterized by deconstruction of causality and the shift of the space-time continuum. The new state of art corresponds to the logic of human knowledge: within the process of renunciation (negating the negation itself), the new knowledge develops out of the opposite side of the old knowledge, which explains why the avant-garde is eternal.
On the Origins of the Preface to the Second Volume of Dmitry Merezhkovsky’s Book L. Tolstoy and Dostoevsky
Authors: Andrushchenko Elena A.
Published: March 2021

The article analyzes the origins of the Preface to the second volume, Religion, of Dmitry Merezhkovsky’s book L. Tolstoy and Dostoevsky (1900–1902). The first publication of the book in Mir iskusstva ended with a Conclusion. When preparing a separate publication of his work (1902), Merezhkovsky published the Conclusion of Religion as a Preface without changing the original text. He used the revised text of the Conclusion for a paper entitled “Leo Tolstoy and the Russian Church” (1903). The paper includes the key points of the talk; it is an almost exact copy of the Preface to the second and third editions of the book (1903, 1909), as well as to both editions of the author’s complete works (Vol. VIII, 1912; Vol. XI, 1914). The article attempts to show the evolution of the author’s original design, explain the motives that encouraged Merezhkovsky to publish the text, reconstruct the context of the heated arguments about his book as well as his reasons to give a talk “Fathers and children of Russian liberalism” (1901).
El Sistema Participativo de Garantías (SPG) como estrategia administrativa en los territorios rurales cafeteros del Cauca, Colombia
Authors: Solarte Montoya Mayra Roxana , Grass Ramírez José Fernando
Published: March 2021

Introducción: La economía campesina, la producción agroecológica, el relacionamiento entre organizaciones sociales de base, la resiliencia al cambio climático y la soberanía alimentaria, son prácticas y propuestas que se fortalecen en los territorios cafeteros del departamento del Cauca, Colombia. Sin embargo, en la primera escala territorial, la finca como sistema integrado de productivo, y en una segunda, el territorio; las dinámicas socio-económicas de la caficultura caucana son incipientes con relación a las certificaciones propias que permitan mitigar los problemas de comercialización de los productos agroecológicos y orgánicos, y fortalecer el relacionamiento directo entre productores y consumidores. Metodología: Es por ello, que en este estudio se plantea una ruta hacia un Sistema Participativo de Garantía (SPG), como estrategia y herramienta de certificación propia de los productos agroalimentarios locales donde se resalte la acción colectiva de las comunidades, se consoliden los lazos de confianza entre productores y consumidores, induciendo a nuevas teorías de gestión organizacional y territorial. Los caficultores del Cauca no solamente producen café, su economía local se enmarca en la comercialización de otros productos provenientes de sus fincas; y actualmente en los mercados convencionales donde generalmente participan, sus productos no están siendo reconocidos por los consumidores como elaborados con prácticas agroecológicas. Como referencia para generar la ruta, se sistematizaron dos experiencias en SPG, de los departamentos de Risaralda y Valle del Cauca, en Colombia, las cuales son lideradas por agricultores agroecológicos de la región. Resultados: En esta modalidad de Investigación-Acción-Participativa (IAP), se logró destacar factores de éxito para la implementación de un SPG y analizar cualitativamente el estudio de caso sistematizado. Para el caso de los caficultores caucanos, se genera la necesidad de explorar la identificación de circuitos comerciales que les permita vender sus productos en canales que reduzcan la participación de intermediarios y acerquen al productor con una venta basada en la confianza directa del consumidor.
A Systematic Review and Meta-analysis to Determine the Effect of Oral Anticoagulants on Incidence of Dementia in Patients with Atrial Fibrillation
Authors: Lin Mingjie , Han Wenqiang , Zhong Jingquan , Wu Lin
Published: March 2021

Aims: To assess the effect of oral anticoagulant (OAC) administration on
incidence of dementia in patients with atrial fibrillation (AF) with
Systematic review and meta-analysis in according with the Preferred
Reporting Items for Systematic Review and Meta-analysis Protocols.
Methods: We systematically searched the electronic databases including
Pubmed, Embase, Cochrane library, and ClinicalTrails.gov for relevant
articles. The primary outcome was the incidence of dementia. The
adjusted risk ratio (RR), odds ratio, or hazard ratio were extracted and
pooled by the random-effects models. Subgroup analysis was performed
according to the setting observational window. Risk of bias was assessed
using the Newcastle-Ottawa Scale, while publication bias was assessed by
the Begg’s and Egger’s tests. Results: Nine studies included in this
review (2 prospective and 7 retrospective observational studies,
including 613,920 patients). The results presented the significant
association between OAC therapy and the reduced risk of dementia
compared with no treatment (RR [95%CI] =0.72 [0.60, 0.86],
I2=97.2%; P =0.000). In the subgroup analysis, the pooled RR became
statistically non-significant (including four studies, RR [95%CI]
=0.75 [0.51, 1.10], I2=98.8%; P =0.000). There is no significant
risk of bias and publication bias. Conclusions: This study indicated the
protective effect of OAC therapy for dementia in patients with AF.
However, the results are limited because of high heterogeneity,
inconsistent direction of effect in subgroup analysis. Further
prospective well-designed study is needed with longer follow-up duration
in younger patients.
Guidelines for planning and monitoring corporate biodiversity performance
Authors: Stephenson Peter J. , Carbone Giulia
Published: March 2021

These Guidelines offer an approach for developing a corporate-level biodiversity strategic plan, including measurable goals and objectives and a set of core linked indicators, that will allow companies to measure their biodiversity performance across their operations. The Guidelines can be used by any company in any sector that has impacts and dependencies on biodiversity, whether large or small, national or multinational. They are aimed at sustainability teams, managers and other company staff whose roles include strategic planning and reporting related to biodiversity. The focus is on a full-cycle, results-based management approach (not just risk analyses, goal setting or indicator development), since assessing pressures on biodiversity, and planning and developing measurable goals, are key prerequisites for monitoring. They also explain how, by choosing and using appropriate core indicators and building internal capacity and partnerships, companies can aggregate and use biodiversity data at the corporate level in a meaningful way.
Meta-analyses of Results From Randomized Outcome Trials Comparing Cardiovascular Effects of SGLT2is and GLP-1RAs in Asian Versus White Patients With and Without Type 2 Diabetes
Authors: Lee Matthew M.Y. , Ghouri Nazim , McGuire Darren K. , Rutter Martin K. , Sattar Naveed
Published: March 2021

BACKGROUND

Results of cardiovascular outcome trials (CVOTs) suggest Asians may derive greater benefit than Whites from newer classes of antihyperglycemic medications.

PURPOSE

To provide summary hazard ratio (HR) estimates for cardiovascular efficacy of sodium–glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs) stratified by race (Asian vs. White).

DATA SOURCES

A systematic review performed in PubMed from 1 January 2015 to 8 December 2020.

STUDY SELECTION

Randomized placebo-controlled CVOTs of SGLT2is and GLP-1RAs that reported HRs (95% CIs) for 1) major adverse cardiovascular event (MACE) in patients with diabetes and 2) cardiovascular (CV) death/hospitalization for heart failure (HHF) in patients with HF and reduced ejection fraction (HFrEF).

DATA EXTRACTION AND SYNTHESIS

HRs (95% CIs) for selected outcomes in Asians and Whites were extracted from each trial, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Random-effects meta-analyses were performed to examine differences between the selected outcomes in Asians versus Whites.

RESULTS

In four SGLT2i trials in type 2 diabetes, the MACE outcome HR (95% CI) in 3,298 Asians versus 20,258 Whites was 0.81 (0.57, 1.04) vs. 0.90 (0.80, 1.00), respectively (Pinteraction = 0.46). In two SGLT2i trials in patients with HFrEF, the CV death/HHF outcome HR in 1,788 Asians versus 5,962 Whites was 0.60 (0.47, 0.74) vs. 0.82 (0.73, 0.92), respectively (Pinteraction = 0.01). In six GLP-1RA trials, the MACE outcome HR in 4,195 Asians versus 37,530 Whites was 0.68 (0.53, 0.84) vs. 0.87 (0.81, 0.94), respectively (Pinteraction = 0.03).

LIMITATIONS

Lack of individual patient–level data, relatively short duration of trial observation, and lack of granular categorization of race within broadly defined Asian subgroups.

CONCLUSIONS

Compared with Whites, Asians may derive greater CV death/HHF benefit from SGLT2is in patients with HFrEF, and MACE benefit from GLP-1RAs in patients with type 2 diabetes.
Patient Markers of Successful Diabetes Management
Authors: Cunningham Amy T. , Arefi Pouya , Gentsch Alexzandra T. , Mills Geoffrey D. , LaNoue Marianna D. , Doty Amanda M.B. , Carr Brendan G. , Hollander Judd E. , Rising Kristin L.
Published: March 2021

PURPOSE

For individuals with diabetes, diabetes health status may not align with A1C targets. Patients may use nonclinical targets when assessing their diabetes management success. Identifying these targets is important in developing patient-centered management plans. The purpose of this study was to identify patient markers of successful diabetes management among patients in an urban academic health system.

METHODS

A secondary analysis of semistructured interviews was completed with 89 adults with type 1 or type 2 diabetes. Participants had a recent diabetes-related emergency department (ED) visits or hospitalization or were primary care patients with an A1C >7.5%. Interviews were conducted to saturation. Demographic data were collected via self-report and electronic medical records. Interviews were analyzed using conventional content analysis. This analysis focused on patient perceptions of successful management coded to “measuring management success.”

RESULTS

Although most participants cited A1C or blood glucose as a marker of successful diabetes management, they had varied understanding of these metrics. Most used a combination of targets from the following categories: 1) A1C, blood glucose, and numbers; 2) engagement in medical care; 3) taking medication and medication types; 4) symptoms; 5) diet, exercise, and weight; and 6) stress management and social support.

CONCLUSION

Individuals not meeting glycemic goals and/or with recent diabetes-related ED visits or hospitalizations had varied understanding of A1C and blood glucose targets. They use multiple additional markers of successful management and had a desire for management discussions that incorporate these markers. These measures should be incorporated into their care plans along with clinical targets.
Patient Markers of Successful Diabetes Management
Authors: Cunningham Amy T. , Arefi Pouya , Gentsch Alexzandra T. , Mills Geoffrey D. , LaNoue Marianna D. , Doty Amanda M.B. , Carr Brendan G. , Hollander Judd E. , Rising Kristin L.
Published: March 2021

Purpose. For individuals with diabetes, diabetes
health status may not align with A1C targets. Patients may use nonclinical
targets when assessing their diabetes management success. Identifying these
targets is important in developing patient-centered management plans. The
purpose of this study was to identify patient markers of successful diabetes
management among patients in an urban academic health system.

Methods. A
secondary analysis of semi-structured interviews was completed with 89 adults
with type 1 or type 2 diabetes. Participants had a recent diabetes-related emergency
department (ED) visits or hospitalization or were primary care patients with an
A1C >7.5%. Interviews were conducted to saturation. Demographic data were
collected via self-report and electronic medical records. Interviews were
analyzed using conventional content analysis. This analysis focused on patient
perceptions of successful management coded to “measuring management success.”

Results.
Although most participants cited A1C or blood glucose as a marker of successful
diabetes management, they had varied understanding of these metrics. Most used
a combination of targets from the following categories: 1) A1C, blood glucose, and numbers; 2) engagement in medical care; 3)
taking medication and medication types; 4)
symptoms; 5) diet, exercise, and weight;
and 6) stress management and social
support.

Conclusion. Individuals
not meeting glycemic goals and/or with recent diabetes-related ED visits or
hospitalizations had varied understanding of A1C and blood glucose targets.
They use multiple additional markers of successful management and had a desire
for management discussions that incorporate these markers. These measures should
be incorporated into their care plans along with clinical targets.
Bilateral Vocal Cord Paralysis Due to Prolonged Intubation in COVID-19 Patients-Case Reports
Authors: BSR Samba
Published: March 2021

Patients typically undergo tracheostomy tube placement after prolonged intubation in order to decrease the risks of endotracheal intubation including laryngeal stenosis, swelling and vocal cord paralysis. This is done prior to 21 days of intubation. During the current coronavirus pandemic there has been an increase in endotracheal intubations and delay in tracheostomy tube placement beyond the 21 days secondary to new recommendations. Presented here are two cases at our institution of patients with the novel coronavirus disease (COVID-19) and prolonged (>21 days) intubation prior to tracheostomy tube placement that have bilateral vocal cord paralysis without laryngeal or tracheal stenosis after extubation. Although the new recommendations of delayed tracheostomy tube placement are intended to decrease spread, there may be increased incidence of unintended effects to the patients.
Oral Cancer Surgery and COVID 19 Pandemic: Our Experience
Authors: Kantharia Shehnaz
Published: March 2021

The COVID 19 pandemic limited the clinical practice of Surgical Oncologists all over the world to performing emergency procedures and surgeries. During this initial period of two to three weeks we realised that further delay in the treatment of curable oral cancers would have serious adverse prognostic implications. So we started the process to formulate our own institutional guidelines to screen and test all preoperative asymptomatic oral cancer patients for COVID 19. All preoperative oral cancer patients were tested for Reverse Transcriptase Polymerase Chain Reaction (RT PCR) and a negative COVID RT PCR report was followed by HRCT Chest. We share our prospectively collected data of Oral Cancer Surgery patients from 14th April to 31st May 2020 with details of sub site, stage, operative procedure and type of reconstruction offered. Our institutional protocol to test all preoperative patients by the highly sensitive HRCT Chest combined with the gold standard RT PCR assay ensured the safety of our patients, attendants and the hospital staff.
The Role of OCB as a Mediator in Improving Employees Performance
Authors: Kadarningsih Ana , Oktavia Vicky , Ali Amjad
Published: March 2021

Employee performance is a measure of the quality of human resources in a company, because employee performance is one important factor for the achievement of a company's goals. Employee performance can be influenced by several factors, such as training, work environment and organizational citizenship behavior (OCB). The purpose of this research is to determine the influence of training and work environment to employee’s performance with Organizational Citizenship Behavior (OCB) as the intervening. This research was conducted at the Semarang City Education Department by taking a sample of 115 respondents registered as active officials of the Semarang City Education Department. Data collection method is done through a questionnaire. Data analysis uses path analysis. The results of the study concluded that there is an influence of training and work environment on OCB, the influence of OCB on employee performance and OCB is able to mediate the relationship between training and work environment on employee performance.
Penerapan Tanggung Jawab Sosial Universitas Melalui Konsep Triple Bottom Line Untuk Mendukung Universitas Yang Berkelanjutan (Studi Pada Universitas Muhammadiyah Di Sidoarjo, Surabaya Dan Gresik)
Authors: Prapanca Detak , Setiyono Wisnu P. , Hanif Aisha
Published: March 2021

The implementation of sustainable development is the responsibility of every level of society, one of which is the university as part of educational institutions in the community. In carrying out its business activities, the university is not only concerned with profit, but also concerned with environmental preservation and the surrounding community. So that sustainable development (sustainable development) can meet the essential needs of the present without having to sacrifice natural resources for future generations. This study aims to find out how the impact of the application of the University's Social Responsibility Implementation Through the Triple Bottom Line Concept to support Sustainable Universities and to find out how the Triple Bottom Line concept in the Universirt Social Responsibility to support sustainable development (Sustainable Development). This type of research is a qualitative approach. This study took place at the Muhammadiyah University of Sidoarjo, Muhammadiyah University of Surabaya and Muhammadiyah University Gresik. This research uses primary data and secondary data. Data analysis and interpretation is done by reducing data, presenting data, interpreting data and drawing conclusions. The results of this study are Muhammadiyah Universities in Sidoarjo, Surabaya and Gresik that have applied the triple bottom line concept in the implementation of university social responsibility (USR) activities in order to achieve sustainable development.
STUDI PERILAKU HARIAN RUSA TIMOR (Cervus timorensis) DI PENANGKARAN RUSA TAHURA WAN ABDUL RACHMAN
Authors: Sofyan Ichvan , Setiawan Agus
Published: March 2021

Penangkaran Rusa Tahura Wan Abdul Rachman merupakan salah satu penangkaran rusa di Provinsi Lampung. Dalam upaya pengembangan rusa timor (Cervus timorensis) di penangkaran tersebut perlu diketahui perilaku hariannya. Tujuan dari penelitian ini adalah untuk mengetahui perilaku harian rusa timor di penangkaran tersebut dan membandingkannya dengan rusa timor di Penangkaran Rusa Taman Satwa Lembah Hijau. Penelitian ini dilaksanakan selama 14 hari pada bulan Juli - Agustus 2016, dan 14 hari pada bulan Desember 2017 - Januari 2018, dimulai dari pukul 06.00 - 18.00 WIB. Metode yang digunakan adalah metode scan sampling, dan objek penelitian adalah jantan dewasa, betina dewasa, jantan anakan, dan betina anakan. Hasil penelitian menunjukkan bahwa rusa timor melakukan perilaku makan dengan persentase 54,05 %, istirahat 33,10 %, berpindah 9,99 %, lainnya (grooming, defekasi, urinasi) 2,45%, sosial 0,26%, bermain sendiri 0,10%, dan tidur 0,05%. Hasil ini berbeda dengan perilaku harian rusa timor di Penangkaran Rusa Taman Satwa Lembah Hijau yang menunjukkan persentase perilaku makan 27,46 %, istirahat 27,11 %, berpindah 16,72 %, bersuara 14,99 %, tidur 8,65 %, dan lainnya 5,07 %. Hasil ini mengindikasikan bahwa jumlah pakan drop in yang diberikan untuk rusa timor di Penangkaran Rusa Tahura Wan Abdul Rachman lebih banyak dibandingkan dengan Penangkaran Rusa Taman Satwa Lembah Hijau.
PENGARUH ARANG AKTIF, BENZILADENIN, DAN KINETIN TERHADAP PERTUMBUHAN TUNAS JATI SOLOMON (Tectona grandis Linn. f) IN VITRO
Authors: Hariadi Husen , Yusnita Yusnita , Riniarti Melya , Hapsoro Dwi
Published: March 2021

Tissue culture techniques can be used for propagation of uniformaly large teak solomon seeds.The purpose of this research was knowing the effect of activated charcoal, the addition of benzyladenine (BA) and combination of BA with 6-furfurylaminopurine (kinetin) to the growth of shoots of solomon teak in vitro. The solomon teak explants used were singlestem cuttings from aseptic shoots obtained from in vitro cultures. This research was conducted in laboratory with complete randomized design with 3 replications. The experimental treatment was a single factor consisting of basic MS medium (Murashige and Skoog, 1962), with 6 treatments: MS without growth regulator (control), MS without growth regulator + 2 g/l activated charcoal, MS + 0,1 m/l BA , MS + 0,2 m/l BA, MS + 0,1 m/l BA + 0,1 m/l kinetin and MS + 0,2 m/l BA + 0,1 m/l kinetin. Observation on the number of books/ shoots, number of leaves/ shoots, shoot/ bud height and visual apperance of culture was taken at 8 weeks after planting. The data were analyzed for variety and continue the separation of the LSD at 5% level. The results showed that in general, all six treatments could be used for propagation of in vitro teak solomon (Tectona grandis Linn. f) and produced at least 6,22 books/ shoots every 8 weeks. The best media were MS medium + 0,1 m/l BA and MS + 0,1 m/1 BA + 0,1 m/l kinetin, because it able to produce 7,78 books/ shoots. The highest number of leaves was obtained at the treatment of MS + 0,1 m/l BA, while the average shoots/ shoots produced were not different for all.
Brief review on spatial planning and its current relation with future studies
Authors: Cisneros Corrales Edison Patricio
Published: March 2021

Purpose – The main objective of the review is to present a short text that serves as a brief introduction point for starters in the study of spatial planning, some of its main topics studied, and the association it has with future studies.Methodology/approach – This review analyzed several high-impact articles about spatial planning. To achieve this, an in-depth review of the literature that involves the issues of spatial planning and future studies was carried out.Originality/value – There is a lack of introductory information in the study of spatial planning and futures studies. This text aims to create a summary that may help future researchers to be introduced in these areas of knowledge. The texts also address different perspectives regarding these two topics.Findings – The concept of planning is analyzed. The relationship that maintains future planning and studies is then established. Subsequently, the main discussions from the academy regarding these two topics are presented.Theoretical/methodological contributions – Planning and spatial planning are systematic processes focused on solving a problem. Spatial planning aims to improve the physical conditions of a certain location. Planning and future studies have been closely related, with ups and downs; in contemporary times these ties have been strengthened, helping to solve complex and turbulent problems. Different points are presented from which spatial planning can be approached, depending on the diversity of contexts.
Marketing de Relacionamento: Perfil da Produção Científica e Agenda de Pesquisa
Authors: Demo Gisela , Lima Talita , Scussel Fernanda , Miranda Paulo , Moreno Lucas
Published: March 2021

Objetivo: haja vista a relevância do marketing de relacionamento para as organizações que operam no mercado consumidor (B2C) e a lacuna na literatura no que tange à comparação do cenário de produção nacional com o internacional, o objetivo deste artigo foi mapear o estado da arte recente sobre relacionamento com o consumidor e propor uma agenda de pesquisaMétodo: realizou-se uma revisão bibliométrica com 435 artigos publicados entre 2015 e 2019, classificados segundo critérios demográficos, institucionais e metodológicosResultados: constatou-se a predominância de artigos empíricos e de natureza quantitativa, além da necessidade de desenvolvimento conceitual para o tema. Há preferência pela aplicação de pesquisas no setor privado, configurando lacuna de pesquisa do tema no que se refere ao setor públicoConclusões: as contribuições residem na apresentação de itinerários de pesquisa, cujo propósito maior é auxiliar o desenvolvimento teórico e empírico do marketing de relacionamento, beneficiando tanto a comunidade acadêmica quanto as organizações
Bioinformatic characterization of the Transmembrane protein95 gene (TMEM95) in Murrah buffalo (Bubalus bubalis)
Authors:   Department of Animal Genetics and Breeding, NTR College of Veterinary Science, Gannavaram, Sri Venkateswara Veterinary University, India, Shireesha Sampathirao , Sudhakar Krovvidi , Vinoo Regula , Seshaiah Chappidi V. , Metta Muralidhar
Published: March 2021

Idiopathic male subfertility is often a neglected phenotype with respect to male fertility in bovines. The gene TMEM95 plays a crucial role in idiopathic male subfertility in cattle. Using the DNA sequence information from cattle TMEM95 gene, we characterized the gene in Murrah buffalo. A total of 2.6 kb of a fragment orthologous to cattle was sequenced from Murrah buffalo and Gir cattle. A 2 bp deletion is present in Murrah buffalo, causing missense mutations in three isoforms that are present in cattle. The functional effects of various non-synonymous mutations were predicted using the SNAP2 program, and showed that the non-synonymous SNPs could affect the protein function. Functional motif annotation revealed the presence of a Casein kinase II phosphorylation site that plays an important role in sperm morphology, Leucine zipper pattern, N-myristoylation site, protein kinase C phosphorylation site, CHRD domain profile, N-glycosylation site and HIT zinc finger motifs in cattle. The HIT ZF motif is absent in all of the functional isoforms in buffalo. The results together suggest that the subfertility gene TMEM95 in cattle and buffalo must have evolved with different functions but plays a role in male fertility as in other mammals.
The molecular epidemiology of Staphylococcus aureus of bovine mastitis origin
Authors:   Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India, Shafi Tawheed Ahmad , Bansal Baljinder K. , Sharma Shukriti , Gupta Dhiraj K. , Singh Randhir
Published: March 2021

The present study was aimed to understand the molecular epidemiology of Staphylococcus aureus (54 isolates), isolated from 422 milk samples obtained from 108 subclinical mastitis affected cows (CMT positive ≥1+ in at least one quarter). The molecular epidemiology of Staphylococcus aureus was studied using coagulase (coa) gene polymorphism, 16S-23S ribosomal spascer (RS-PCR) polymorphism and Staphylococcal protein A (Spa) typing. Staphylococcus aureus produced 7 coagulase genotypes and 8 RS genotypes respectively. Coagulase genotype GTIII (730 bp) was the most prevalent (35 strains) followed by GTV (900 bp, 7 strains) and GTIV (800 bp, 4 strains), whereas RS genotypes GTA accounted for the highest number of strains (31 strains), followed by GTB (11strains), GTH (4 strains) and GTE (3 strains). Coagulase genotype CTIII (730 bp) showed the highest diversity, as isolates within it produced 5 RS genotypes, the majority of them belonging to the RS genotype GTA (29 out of 31 strains). Forty out of 54 Staphylococcus aureus samples isolated in this study were correctly typed by spa typing, and were assigned to 21 known spa types, and one new novel spa type t18462. The study revealed high diversity within Staphylococcus aureus strains, consisting of 7 coagulase genotypes, 8 RS genotypes and 22 spa types.
Evaluation of some environmental and genetic factors (CSN3 and AGPAT6 gene) on milk yield and composition in Saanen goats
Authors:   Department of Genetics, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Nilufer, Turkey, Dincel Deniz , Ardicli Sena , Samli Hale , Ogan M. Mustafa , Balci Faruk
Published: March 2021

This study was designed to determine the effect of some environmental factors on milk yield and composition in Saanen goats and the effect of CSN3 and AGPAT6 gene polymorphisms on milk production traits. Saanen goats were genotyped for milk traits, and the samples were collected during the lactation, and the milk yield/compositions of each goat were specified. In terms of the CSN3 and AGPAT6 genes, the genotypes were defined by PCR-RFLP. The milk yield (MY), lactation length (LL), protein, fat, total solid (TS), solid not fat (SNF), casein, lactose rates and yields were as follows; 388.9 ± 17.5 kg, 243 ± 5.81 days, 3.29 ± 0.05%, 3.59 ± 0.07%, 11.60 ± 0.13%, 8.43 ± 0.06%, 2.57 ± 0.04%, 4.31 ± 0.03%, 11.21 ± 0.47 kg, 12.79 ± 0.64 kg, 40.95 ± 1.82 kg, 29.53 ± 1.31 kg, 8.82 ± 0.37 kg, 15.40 ± 0.74 kg respectively. The determined genotype and allele frequencies of CSN3 and AGPAT6 gene were as follows; FF (%99.20), MF (%0.80), F (0.996), M (0.004); GG (%12), GC (%43.20), CC (%44.80), G (0.336), C (0.664). The impacts of lactation length on all milk yield parameters (protein, fat, TS, SNF, casein, lactose, MY) (P<0.001); the age on all milk yield parameters (P<0.001) and the protein, fat, SNF, casein rates (P<0.05), the TS rate and LL (P<0.01) were found to be significant. The birth type was not found to significantly affect any milk yield parameters. Although Saanen goats showed the variation for the AGPAT6 gene (g.9263C>G), the herd was found to be monomorphic (FF) for the CSN3 gene. The effect of the AGPAT6 gene on milk traits in Saanen goats was determined not to be statistically significant. Environmental factors, such as maternal age and lactation length, were found to significantly affect some milk traits in Saanen goats. So consideration of factors such as maternal age or lactation length could be useful for improving breeding strategies for dairy goats.
An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper
Authors:   Department of Internal Medicine, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey, Değirmençay Şükrü , Çamkerten Güzin , Çamkerten İlker , Aktaş M. Sinan
Published: March 2021

This study aimed to investigate the diagnostic value of thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels in evaluating oxidative stress in dogs with canine distemper. The study materials consisted of 24 cross-breed dogs: 18 dogs with canine distemper (CD group) and 6 healthy dogs as the control. Blood samples for analysis of antioxidant-oxidant parameters were taken from both groups. In addition to TDH parameters (native thiol [NT], total thiol [TT], and disulfide [Ds] levels and Ds/NT, Ds/TT, and NT/TT ratios), IMA and albumin (ALB) levels were also determined in the blood serum of the groups. The IMA levels of the CD group were significantly higher than the control group (P<0.05). Antioxidant parameters (NT, TT) and oxidant parameters (Ds, Ds/NT, and Ds/TT) both exhibited a significant positive correlation among themselves (P<0.01). The areas under the ROC curve of IMA, Ds/NT, and Ds/TT were 0.78, 0.62, and 0.62 respectively. The high levels of IMA, Ds, Ds/NT, and Ds/TT and low levels of NT, TT, NT/TT and ALB in dogs with canine distemper can be used to assess the oxidative stress caused by the disease. Overall, the diagnostic performances of IMA, Ds/NT, and Ds/TT for detection of increased oxidative stress were similar, but IMA was superior.
The influence of season and age on the levels of lipids, lipoproteins and enzymes in the serum of Lička pramenka sheep
Authors:   Department of Hygiene, Technology and Food Safety, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia, Mikuš Tomislav , Kozačinski Lidija , Cvrtila Željka , Vince Silvijo , Špoljarić Branimira , Perkov Sonja , Kardum Paro Mirjana Marijana , Špoljarić Daniel , Pajurin Luka , Popović Maja
Published: March 2021

This study aimed to identify seasonal and age related variability in triglycerides (TRI), paraoxonase (PON), stimulated PON (PON I) and cholesterol (CHOL, HDL, LDL) in extensively reared Lička pramenka sheep. The study was conducted 30 randomly chosen non-gravid Lička pramenka sheep on an extensive farm, grouped into three age groups in the Karlovac County, Croatia. Blood was collected by venepuncture of the jugular vein, twice in one year - the first sampling in spring (April) and the second in autumn (October). The results showed that age had no significant effect on any of the investigated indicators, while seasonality significantly affected five out of the six parameters examined. Significantly higher levels of serum lipid components in autumn can be explained by the influence of the traditional way of rearing and feeding Lička pramenka sheep. Furthermore, the results of PON I in all three age groups showed that the sheep are well adapted to the environment and to the rearing system. Future research should be carried out on higher number of farms, and should include more sheep in order to determine objective benchmarks for serum lipids and the enzymes connected to those lipids.
Accelerated Idioventricular Rhythm and Hypokalemia, Atypical Presentation in the Midst of a Pandemic
Authors: Rodríguez-Artuza Carlos , Torres Mayela Labarca , Meza José
Published: March 2021

A 34-year-old female patient was referred to a private center from a rural population due to exertional dyspnea and palpitations for 15 days being previously asymptomatic, a surface electrocardiogram diagnoses sinus rhythm alternating with accelerated idioventricular rhythm with episodes of short-coupling intervals. When conducting a diagnostic investigation, hypokalemia and decreased serum magnesium were evidenced and, after correction of the water-electrolyte imbalance, the electrocardiographic disorders disappeared.
Advances in Physiological Cardiac Stimulation
Authors: Reis Gustavo Galli , Ferrari Andres Di Leoni , Cabral Gustavo Chiari , Gazzoni Guilherme Ferreira , Ley Luis Manuel , Willes Jessica Caroline Feltrin , Ferreira Flavio Vinicius Costa , Lodi Laura Orlandini
Published: March 2021

Advances in cardiac stimulation demonstrate that bradyarrhythmia treatments go beyond heart rate control. The concern with the ventricular stimulation site and, consequently, with the maintenance of intraventricular synchrony has become routine in most services. Techniques of physiological cardiac stimulation, such as stimulation of the bundle of His and the left branch, have been improved. Despite the indisputable benefits of these therapeutic modalities, there are technical difficulties that limit systematic use. In this sense, to make physiological cardiac stimulation more practical and reproducible, the concept of parahissian stimulation was expanded and studied. The technique, simpler and reproducible, contemplates a conventional approach of the right ventricle. The big difference is the use of QRS spatial variance analysis technology (Synchromax®, Exo S.A., Argentina) to confirm the maintenance of ventricular synchrony according to the implanted site.
PENGARUH STRES KERJA, KEPUASAN KERJA DAN KOMPENSASI FINANSIAL TERHADAP KINERJA KARYAWAN
Authors: Dharmayasa Putu Bagoes , Adnyani I Gusti Ayu Dewi
Published: March 2021

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh stres kerja terhadap kinerja karyawan, untuk menganalisis pengaruh kepuasan kerja terhadap kinerja karyawan dan untuk menganalis pengaruh kompensasi finansial terhadap kinerja karyawan. Populasi dari penelitian ini adalah seluruh karyawan outdoor yang berhubungan langsung dengan tamu sebanyak 103 orang dan seluruh populasi dijadikan sebagai sampel penelitian dengan teknik sampel jenuh (saturated sampling) yaitu teknik sensus. Analisis data dalam penelitian ini yaitu analisis regresi linier berganda. Hasil dari penelitian ini menunjukan bahwa (1) Stres kerja berpengaruh negatif terhadap Kinerja karyawan, (2) Kepuasan kerja berpengaruh positif terhadap Kinerja karyawan dan (3) Kompensasi finansial berpengaruh positif terhadap Kinerja karyawan. Sebaiknya pihak manajemen perusahaan hendaknya tidak memberikan tanggung jawab yang tidak sesuai dengan jabatan serta deskripsi pekerjaan yang diemban karyawan, merancang lingkungan kerja yang mendukung serta menerapkan kebijakan agar karyawan antar satu dengan yang lain dapat memberikan dukungan serta hendaknya memberikan insentif yang sesuai dengan kinerja karyawan.

Kata kunci: stres kerja, kepuasan kerja, kompensasi finansial, kinerja karyawan.