bluuebunny/crossref_metadata_2025 huggingface dataset:
Character Education Orientation In Learning Reading Skills
Authors: Syahrin Alfi , Hamid Marwan , M Usman , As Amru Bin , H Muhammad
Published: November 2022

The problems surrounding character or morals that occur today are much more numerous and more complex than the character problems that occurred in previous times. The problem of character is a matter of thought as well as a common concern because this country can be considered a character crisis. Almost all the time, the media is filled with news of increasing promiscuity, rampant rates of violence against children and adolescents, drugs, theft, and deprivation have become social problems that have not been resolved completely. Therefore, the main purpose of this paper is to reveal and explain the orientation of character education in learning reading skills with the philosophy of religion and Pancasila. In this discussion, the problems, relationships, and proper strategies for implementing character in education will be revealed.
Pengembangan Media Halma Untuk Meningkatkan Kemampuan Berhitung Kelipatan Suatu Bilangan Siswa Kelas IV
Authors: Handono Tri , Suad Suad , Utaminingsih Sri
Published: November 2022

The purpose of this study was to develop learning media for the halma game to improve the ability to count multiples of a number for grade 4 SD in Demak Regency. This research method is Research and development. There are 3 stages in this research: the preliminary study stage, the development stage, media validation, and field testing, as well as the dissemination and socialization stage. The results of this study are in the form of manual learning media products in the form of multiples number board games from paper and MMT, and digital, in the form of digital in the form of a game application using articulate storyline 3. Validation from media experts and material experts gave assessments, validators I, II, III, and IV respectively 36, 35, 37, and 36 from a maximum score of 40. The media developed was categorized as very good. The results of the control class posttest t test and the experiment shows the value of t = -336 with a Sig. (2-tailed) value of 0.664 bigger than α = 0.05, so that the media developed is valid.
Análise jurisprudencial da responsabilidade civil do Estado por danos causados a presos mantidos em regime prisional mais rigoroso
Authors: Wiemes Julia Salles , Oliveira Rafael Niebuhr Maia de
Published: November 2022

Busca-se analisar a responsabilidade civil do Estado pelos danos causados a sentenciado que cumpre pena em regime prisional mais rigoroso do que faz jus, atentando-se em apresentar as principais discussões doutrinárias e jurisprudenciais sobre o assunto. Para tanto, utiliza-se do método dedutivo, operacionalizado pela técnica de pesquisa bibliográfica em obras jurídicas e documental, esta por meio de análise jurisprudencial. Ao concluir a pesquisa, tem-se que o ordenamento jurídico brasileiro entende cabível a propositura de ação indenizatória frente à situação ilegal a qual o condenado é submetido, sendo que para a configuração de responsabilidade civil do Estado faz-se necessária a comprovação de sua conduta omissiva ou comissiva, bem como do dano e o liame causal entre ambos e, ainda, quando se tratar de conduta estatal exclusivamente omissiva, para os adeptos da responsabilidade subjetiva, imprescindível a constituição de prova da culpa estatal. Além disso, verifica-se que, apesar de se tratar de tema recente em que não se há discussão em larga escala, ainda que timidamente, paulatinamente os tribunais brasileiros vêm reconhecendo como devidos tanto os danos materiais quanto morais ao condenado submetido a esta situação.
Explaining the Conditions of Realization of Responsibility in Repairing Detriments Caused by Void Transactions
Authors: Anari Mohsen , Bashokouh Mozaffar , Lofti Alireza
Published: November 2022

As long as the basic conditions of the accuracy of the contract and the specific conditions necessary for the accuracy of some contracts are met and the contract does not contradict public order and good ethics, the principle is the accuracy of the contracts. In case of loss or non-compliance with any of these conditions, the marriage will be invalid. Invalidation of the marriage has some effects, including the responsibility of one of the parties to the invalid contract in compensation for detriments to the other party of the marriage. Liability arising from a void contract and the obligation to compensate for the detriments arising from it is of non-contractual origin. In order to achieve the purpose of civil liability, i.e. to fully compensate for detriments, it is essential to determine the best method of compensation that courts in each case consider relative compensation and avoid compensating for any kind and order to pay cash for detriments in all cases. In the event of a breach of obligation, it is conceivable that it violates the obligation, which has a variety of types and includes civil or coercive liability, contractual liability, criminal and moral liability. The conditions for the realization of responsibility are: indisputableness, directness, personality, lack of prior compensation, foreseeeability, and detriment to the legitimate right to be detrimentd.In this paper, we try to use descriptive-analytical method and library study.Explaining the conditions of realization of responsibility in repairing detriments caused by void transactions to discuss.
A (im)possibilidade de inclusão do abandono afetivo como uma hipótese de deserdação no ordenamento jurídico brasileiro
Authors: Werle Caroline Cristiane , Fraga Juliana Machado , Ferreira Willian Silveira
Published: November 2022

Esta pesquisa tem como principal objetivo verificar a possibilidade de incluir o abandono afetivo como hipótese de deserdação no âmbito do ordenamento jurídico brasileiro, especialmente em virtude da importância da afetividade no seio das relações familiares. Desta feita, o problema que se pretende responder neste artigo é o seguinte: considerando a relevância da afetividade no âmbito das famílias brasileiras, é possível a inclusão do abandono afetivo como uma hipótese de deserdação no ordenamento jurídico brasileiro? Assim, no primeiro item do trabalho serão construídos breves apontamentos sobre o direito de família no Brasil e o princípio da afetividade. Na sequência, o artigo irá tratar sobre o Direito Sucessório e as formas de exclusão dos herdeiros por indignidade e deserdação. Por fim, será investigada a possibilidade de inclusão do abandono afetivo como hipótese de exclusão de herdeiro por meio da deserdação. Concluiu-se, com a pesquisa, que é possível a inclusão do abandono afetivo como uma causa de deserdação, de modo que hoje há, inclusive, um projeto de lei tramitando no Congresso Nacional atinente à matéria. Contudo, destaca-se que o ideal seria incluir o abandono afetivo enquanto hipótese de indignidade, visto que, assim, sua efetividade prática seria maior. Por fim, destaca-se que será utilizado o método de abordagem dedutivo. Com relação ao método de procedimento, será utilizado o monográfico. No tocante à técnica de pesquisa, esta se valerá da técnica bibliográfica.
Limites jurídicos da utilização da imagem de atletas em jogos eletrônicos
Authors: Alves Fabricio Germano , Moura Gabriel Lins Procópio de , Gomes Lucas Quirino
Published: November 2022

Este artigo aborda a questão do licenciamento de times e atletas nos jogos eletrônicos na perspectiva do direito brasileiro, tendo como problemática os limites jurídicos quanto à utilização da imagem de atletas em jogos eletrônicos, havendo uma breve comparação com o direito americano. A partir disso, formula-se a hipótese de que o direito de imagem é encarado com uma lógica mais mercadológica nos Estados Unidos que a do Brasil. Para tanto, utiliza-se a metodologia bibliográfica, explorando-se o pensamento de doutrinadores jurídicos dos Direitos Civil e Constitucional, bem como havendo análise da legislação nacional aplicável e do entendimento jurisprudencial de uma corte superior brasileira. Na análise de julgado do Superior Tribunal de Justiça (STJ), pode-se perceber que a utilização indevida da imagem de atletas em jogos eletrônicos sujeita, concomitantemente, ao pagamento de indenização a desenvolvedora dos referidos jogos e as associações esportivas que os desportistas representam, caso elas tenham permitido o uso da imagem dos atletas em contrato com a desenvolvedora sem a autorização deles. O início da contagem do prazo prescricional para a ação indenizatória pelo uso não autorizado da imagem de desportista em jogos eletrônicos ficou definido como o último ato que viola o direito de imagem, considerada a manutenção da exploração do jogo eletrônico violador, havendo prevalecido no STJ o entendimento sustentado pela teoria da actio nata objetiva.
Eco-dependent osteopenia as a manifestation of eсo-pathology in children
Authors: Kech N.R. , Lukyanenko N.S. , Chaykovska H.S. , Lychkovska O.L. , Kulachkovska I.Yu. , Hnateyko N.O.
Published: November 2022

The research aim is to identify epigenetic factors of eco-dependent osteopenia occurrence and progression in children.

Materials and Methods. The research focuses on analyzing the medical documentation of 41 children aged between 3 and 16 from ecologically unfavorable locations (Burshtyn, Kalush, Dolyna towns) and 73 children of the same age from an ecologically friendly location (Gorodenka town) in Ivano-Frankivsk Region. The children underwent clinical examination and diagnostic instrumental studies.

Results and Discussion. We analyzed and compared the nature and incidence of complaints in children from ecologically unfavorable and ecologically friendly locations. The significant number of complaints were associated with the syndrome of general nonspecific intoxication, which was confirmed by clinical manifestation of eco-pathology. Ultrasound densitometry was used to determine bone mineral density (BMD). Blood and urine Ca levels were also measured.

Conclusions. The skeletal pathology manifested by osteopenic syndrome was diagnosed in most of examined children. This indicates a high incidence of eco-dependent osteopenia in children from ecologically unfavorable regions. The identified patterns were confirmed in the examined children by ultrasound densitometry, hypocalcemia, and hypercalciuria.
CLINICAL FEATURES OF PREGNANT WOMEN WITH EARLY GESTOSIS
Authors: Hvozdetska Halina , Henyk Natalia
Published: November 2022

Aim: to determine the clinical features of women with early gestosis.

Materials and Methods. The retrospective study included 200 pregnant women. The main group included 150 pregnant women with early gestosis. The control group included 50 women with physiological pregnancies.

Results. Among pregnant women with early gestosis, the share of unemployed women (30.0%), workers in enterprises and agriculture (24.0%) and female students (22.0%) was significant, (р<0,001). Cigarette smoking was identified in 20.0% of women in the main group. In childhood, 32.0% of women with early gestosis suffered from childhood infectious diseases. In women with early gestosis, somatic pathology was probably more common: diseases of the gastrointestinal tract (52.0%), diseases of the cardiovascular system (40.0%); anemia (38.0%); pathology of the urinary system (18.0%); endocrine diseases (20.0%), psycho-emotional disorders (38.0%), (р<0,001, c2 =13,20). Abnormal uterine bleeding are observed in 18.0% of women in the main group. The rate of inflammatory diseases of the pelvic organs among pregnant women with early gestosis was 32.0%, cervical pathology - 16.0%; the level of artificial abortions was 26.0%, (р<0,001, c22 = 22,74).

Discussion. Nausea and vomiting in pregnant women is one of the most common pregnancy disorders. Symptoms occur mainly in the first trimester, although in some patients they may persist throughout pregnancy and affect a woman's quality of life. The pathogenesis of early gestosis remains unclear, but there is a consensus that these disorders are multifactorial and that various genetic, psychological, endocrine, and infectious factors may be involved. Our retrospective analysis of the premorbid background in women with early gestosis revealed its peculiarities. The high level of somatic morbidity and smoking in women with early gestosis in comparison with pregnant women of the control group corresponds to modern ideas about the importance of extragenital pathology and bad habits in the etiopathogenesis of pregnancy complications.

Conclusions. The results of this study show that women with early gestosis are characterized by a high level of somatic diseases and psycho-emotional disorders, smoking, relatively unsatisfactory social conditions.

Relationship with research programs, plans and topics. This work is a fragment of the scientific work of the I.D. Lanovyi Department of Obstetrics and Gynecology "Development of diagnostic tactics and pathogenetic substantiation of effective methods of preserving and restoring reproductive potential and improving the quality of life of women in obstetric and gynecological pathology" (state registration number 0121U109269).
COMPARISON OF THE EFFICIENCY OF NON-PENETRATING DEEP SCLERECTOMY AS A STANDALONE SURGERY AND MODIFIED NON-PENETRATING DEEP SCLERECTOMY IN COMBINATION WITH AB INTERNO ENDOTRABECULECTOMY
Authors: Levytska Olha , Novytskyi Ihor
Published: November 2022

Aim. To compare the hypotensive effect of non-penetrating deep sclerectomy (NPDS) as a standalone surgery and non-penetrating deep sclerectomy in combination with dosed endotrabeculectomy in patients with primary open-angle glaucoma.

Materials and Methods. 27 patients (27 eyes) with primary open-angle glaucoma were under our follow-up. In the first group (15 patients) we performed a non-penetrating deep sclerectomy, in the second group (12 patients) - a combined surgery.

Results and Discussion. When comparing values, we found that the difference between the preoperative and postoperative IOP, as well as the preoperative and postoperative amount of topical antihypertensives used, was significant up to the 12th month inclusive in both groups (p<0.05). No significant difference was found when comparing IOP values between two groups in the same follow-up periods. However, there was a difference in the amount of topical intraocular pressure-lowering agents used by two groups in the 12th month of follow-up.

Conclusions. Non-penetrating deep sclerectomy, both standalone and in combination with endotrabeculectomy, has a significant hypotensive effect in patients with primary open-angle glaucoma during 12 months of follow-up, however, patients of the first group instilled a higher amount of topical antihypertensives in the 12th month of follow-up, which makes us consider the hypotensive effect of the combined surgery to be higher.
The relationship between talent management and the efficiency of head nurses and senior and middle managers from the educational and medical centers in Tabriz, Iran – a case study
Authors: Chelan Sajad Hadi ,   School of Management and Social Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran, Alimohammadzadeh Khalil ,   Department of Healthcare Management, School of Management and Social Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran,   Health Economics Policy Research Center, Tehran Medical Sciences Islamic Azad University, Tehran, Iran,   Khalil Alimohammadzadeh, Department of Healthcare Management, School of Management and Social Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran. Health Economics Policy Research Center, Tehran Medical Sciences Islamic Azad University, Tehran, Iran. E-mail: dr_khalil_amz@yahoo.com,   https://orcid.org/0000-0002-2376-9256, Maher Ali ,   Department of Healthcare Management, School of Management and Social Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
Published: November 2022

Nowadays, organizations understand that they need the best talent to succeed in the complex world economy and survive in a competitive business environment. Therefore, talent management can ensure that each employee with a unique talent or ability will be placed in the correct position. This article aimed to study the relationship between talent management, senior and middle managers, and head nurses from educational health and research centers in Tabriz, in 2016. The target population included senior and middle managers and head nurses from Tabriz University of Medical Sciences, approximately 197 people. The sample for this study was selected based on Morgan's table, which rounds up to 123 people. The Kolmogorov-Smirnov test was used to analyze data, and if data were normal, correlation and regression analysis were performed. There was a significant relationship between talent management and the efficiency of senior and middle management and head nurses from the educational and medical centers in Tabriz. Therefore, when talent management increases, the efficiency level also rises to a noticeable degree. Also, the linear regression showed a linear relationship between talent management as an independent variable and efficiency as a dependent variable. Applying talent management strategies in the management selection process in organizations with demanding environments such as hospitals seems inevitable so that managers with the highest efficiency are hired.
Oral health knowledge, attitude, and practice of pregnant women in Deccan, South India: a cross-sectional prenatal survey
Authors: Ahmed Javali Mukhatar ,   Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia, Abullais Saquib Shahabe ,   Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia,   Shahabe Abullais Saquib,Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia. E-mail: drsaquib24@gmail.com, Abdul Khader Mohasin ,   Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia, Khalid Imran ,   Department of Oral and Maxillofacial Surgery, College of Dentistry, King Khalid University, Abha, Saudi Arabia, Yahya AlShahrani Abdulrahman ,   Department of Dentistry, Albashaier Hospital, Ministry of Health, Bisha, Saudi Arabia, Ahmed Kanji Masroor ,   Department of Prosthodontics, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia, Asiri Elyas ,   Department of Dentistry, Ministry of Health Clinics, Abha, Saudi Arabia
Published: November 2022

Pregnancy is a unique condition for women, associated with physiological and emotional changes in the body. Various research showed an association between periodontal disease and adverse pregnancy outcomes. Importance to hygiene maintenance should be given during pregnancy and improve the wellbeing of the mother and child. This study assessed oral health knowledge, attitude, and practices among pregnant women in Hyderabad. The study design was cross-sectional and included 445 women who responded and completed the survey. Subjects were selected using a random sampling technique in gynecology clinics. The questionnaire form consisted of four sections: demographic data, knowledge, attitude, and oral hygiene practice. Out of the 482 pregnant females invited to participate in the study, 445 women completed the survey, giving a response rate of 92%. The majority of women showed good knowledge and attitude regarding oral hygiene and its relation to pregnancy. However, the participants showed poor compliance with the recommended protocol. There are certain myths and barriers to dental treatment that need to be considered in the prenatal education of women. If explained by the gynecologist, the importance of oral health and its correlation with systemic health will play a crucial role in improving oral hygiene practice and regular dental visits.
The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats
Authors: Reza Salahshoor Mohammad ,   Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran, Azari Paria ,   Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran, Roshankhah Shiva ,   Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran, Zokaei Abdolhamid ,   Cardiovascular Research Center, Kermanshah University of Medical Science, Kermanshah, Iran, Foroughinia Azadeh ,   Cardiovascular Research Center, Kermanshah University of Medical Science, Kermanshah, Iran,   Azadeh Foroughinia, Cardiovascular Research Center, Kermanshah University of Medical Science, Kermanshah, Iran. E-mail: Aforoughinia@gmail.com
Published: November 2022

Nitrosamines are carcinogenic agents which can unfavorably affect some male reproductive parameters. Humans are exposed to nitrosamines through various routes, the most important of which is the diet. Crocin is a carotenoid and is accountable for the red color of saffron. Crocin has numerous pharmacological actions, such as antioxidant roles and radical scavenging. The aim of this study was to evaluate the effects of Crocin against Nitrosamine – induced damage to the reproductive parameter of male rats. In this experimental study, 48 male rats were randomly assigned to 8 groups: control normal and Nitrosamine control groups (40 mg/kg); Crocin (12.5, 25, and 50 mg/kg) and Nitrosamine + Crocin (12.5, 25, and 50 mg/kg). Treatments were administered intraperitoneally and gavaged daily for 28 days. The sperm parameters, total antioxidant capacity, testosterone level, and seminiferous tube diameter were assessed. Nitrosamine significantly decreased sperm parameters (p<0.001). The Crocin and Crocin + Nitrosamine treatments at complete doses significantly improved all parameters (p<0.001). Crocin compensated for the toxic effect of Nitrosamine on reproductive parameters.
SARS-COV-2 – the pandemic of the XXI century, clinical manifestations – neurological implications
Authors: Saceleanu Vicentiu ,   Department of Neurosurgery, Faculty of Medicine, Lucian Blaga University, Sibiu, Romania,   Department of Neurosurgery, County Emergency Hospital, Sibiu, Romania, Moreanu Mihai-Stelian ,   Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Mihai-Stelian Moreanu, Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: moreanumihai@yahoo.com, Covache-Busuioc Razvan-Adrian ,   Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, George Mohan Aurel ,   Department of Neurosurgery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania,   Department of Neurosurgery, County Emergency Hospital, Oradea, Romania, Ciurea Alexandru-Vlad ,   Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Department of Neurosurgery, Sanador Clinical Hospital, Bucharest, Romania
Published: November 2022

In December 2019, in Wuhan, China, the first cases of infection with SARS-CoV 2 responsible for COVID-19 disease were identified. SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emerging pandemic could leave raises awareness on the importance of understanding the mechanisms that underlie the developing conditions. The epidemiology, clinical picture, and pathogenesis of COVID-19 show that this virus presents new strategies to overcome the past defensive medicine. While all the current data has focused on the pulmonary and cardiovascular manifestations, little has been written about the neurological implications of the disease. This review updates new clinical aspects that SARS-CoV 2 expresses in humans by focusing primarily on neurological manifestations. The damage to the nervous system became more apparent - anosmia, ageusia, polyneuritis, meningitis, meningoencephalitis, stroke, acute necrotizing encephalopathy. Oxygen therapy is vital for those in critical health situations. Finally, prevention is the most important element in breaking the epidemiological chain.
The levels of oxidative stress in a combination of stress factors
Authors: Ilderbayev Oralbek ,   Department of General Biology and Genomics, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan,   Oralbek Ilderbayev, Department of General Biology and Genomics, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan. E-mail: oralbekzainuld@rambler.ru,   https://orcid.org/0000-0002-8137-4308, Okassova Assem ,   Department of General Biology and Genomics, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan,   https://orcid.org/0000-0002-3022-9741, Rakhyzhanova Saule ,   Department of Physiological Disciplines, Semey Medical University, Semey, Kazakhstan,   https://orcid.org/0000-0001-5507-0610, Ilderbayeva Gulzhan ,   Department of Biotechnology and Microbiology, Natural Science Faculty, NCJSC L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan,   https://orcid.org/0000-0002-5854-8410, Zhazykbayeva Lashyn ,   Department of Physiological Disciplines, Semey Medical University, Semey, Kazakhstan,   https://orcid.org/0000-0001-6529-284X
Published: November 2022

We studied the effect of the combined action of ionizing radiation and induced immobilization stress on the lipid peroxidation process and antioxidant protection of organs (mesenteric lymph nodes, spleen, adrenal glands, thymus, and liver) and immune cels - the blood lymphocytes. Results were obtained on the role of free-radical oxidation in combination with exposure to ionizing radiation and immobilization stress at an early stage in the experiment. Gamma radiation in the acute period resulted in significant changes in lipoperoxidation and antioxidant systems. The first period of immobilization stress was marked by the imbalance of LPO-AOS systems disturbance with an accumulation of toxic compounds in tissues which had affected their function. The combined sublethal gamma radiation and immobilization stress disturbed the functional activity of adaptive systems of the body in the early stage of adaptation syndrome. Furthermore, the results show the dominant role of ionizing radiation in it.
Medication-related osteonecrosis of the jaw: knowledge and perceptions of medical professionals on the usage of bone modifying agents and dental referrals
Authors: Acharya Shruthi ,   Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, Patil Vathsala ,   Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India,   Vathsala Patil, Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. E-mail: drvathsala19@gmail.com; vathsala.mcods@manipal.edu, Ravindranath Vineetha ,   Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, Kudva Adarsh ,   Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, Nikhil Krithi ,   Department of Public Health Dentistry, SDM College of Dental Sciences and Hospital, Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India
Published: November 2022

Bone modifying agents (BMA) like bisphosphonates, antiangiogenic, and antiresorptive agents are widely used to manage bone diseases and cancer. Medication-related osteonecrosis of the jaw (MRONJ) is a potentially serious complication seen in patients on BMA therapy. Dental infection is one of the primary risk factors for MRONJ manifestation; hence its complete removal before initiation of BMA is significant. This can be achieved when a medical professional understands MRONJ and its risk factors and implements timely and regular dental referrals. This multicentre study was performed to assess the knowledge about MRONJ and awareness about the implementation of dental referrals among medical professionals. A custom-designed questionnaire tool was designed and validated by a pilot study. 450 practitioners from 6 medical schools and private practitioners in and around the district were surveyed. The results were analyzed using descriptive statistics. 63.5% (n=80) of the respondents prescribed bisphosphonates at a frequency of 0–5 times in a month. However, 62% (n=78) of the practitioners could correctly indicate the most appropriate definition of MRONJ. Only 49.2% (n=62) of them considered dental consultation mandatory. 73% (n=92) of the practitioners were unaware of management guidelines. There exists a significant gap in the knowledge-based applications in the management of MRONJ. Lack of referrals to dentists before BMA therapy can be a pivotal factor in patient morbidity. Practitioners prescribing BMA should advise patients about regular dental visits and monitor for symptoms of MRONJ.
A review and revisit of nanoparticles for antimicrobial drug delivery
Authors: Bin Liew Kai ,   Department of Pharmaceutical Technology and Industry, Faculty of Pharmacy, University of Cyberjaya, Cyberjaya, Selangor, Malaysia,   Kai Bin Liew, Faculty of Pharmacy, University of Cyberjaya, Cyberjaya, Selangor, Malaysia. E-mail: liewkaia@yahoo.com, Kumar Janakiraman Ashok ,   Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia, Sundarapandian Ramkanth ,   Karpagam College of Pharmacy, Othakalmandapam, Tamil Nadu, India, Haroon Khalid Syed ,   Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan, Abdul Razzaq Fizza ,   Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan, Chiau Ming Long ,   PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam, Khan Abdullah ,   School of Pharmacy, KPJ Healthcare University College, Nilai, Negeri Sembilan, Malaysia, Kalusalingam Anandarajagopal ,   School of Pharmacy, KPJ Healthcare University College, Nilai, Negeri Sembilan, Malaysia, Wei Ng Pit ,   Department of Pharmacy, National University Hospital, Singapore
Published: November 2022

Antimicrobials are widely used to treat bacteria, viruses, fungi, and protozoa. Therefore, research and development of newer types of antimicrobials are important. Antimicrobial resistance has emerged as a major challenge to the healthcare system, although various alternative antimicrobials have been proposed. However, none of these show consistent and comparable efficacy to antimicrobials in clinical trials. More recently, nanoparticles have emerged as a potential solution to antimicrobial agents to overcome antimicrobial resistance. This article revisits and updates applications of various types of nanoparticles for the delivery of antimicrobial agents and their characterization. Though nanoparticle technology has some limitations, it provides an innovative approach to pharmaceutical technology. Furthermore, nanoparticles offer a variety of advantages, such as enhancement of solubility and permeation, leading to better efficacy. In this article, approaches commonly employed to improve antimicrobial therapy are discussed. These approaches have advantages and applications and provide a broader opportunity for pharmaceutical scientists to choose the proper method per the desired outcome.
Ethical challenges of cord blood banks: a scoping review
Authors: Gerdfaramarzi Madjid Soltani ,   1 Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Bazmi Shabnam ,   1 Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Kiani Mehrzad ,   1 Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Afshar Leila ,   1 Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Fadavi Mohsen ,   1 Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Enjoo Seyed Ali ,   1 Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Seyed Ali Enjoo, Department of Medical Ethics, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. E-mail: seyed.ali.enjoo@gmail.com,   https://orcid.org/0000-0002-9743-8046
Published: November 2022

Cord blood is a rich source of hematopoietic stem cells used to treat many diseases of blood origin. Thus, storage banks were created to store and provide umbilical cord cells. With the development of diagnostic and therapeutic technologies and techniques in medicine, ethical issues have also become more widespread and complex. After the creation of the cord blood banks, efforts were made to address the ethical issues associated with such banks. The present study attempts to identify the ethical challenges in these banks in the published studies. Databases including PubMed, Scopus, Web of Science (WOS), Embase, Proquest, and Google Scholar were searched from January 1996 to January 2021. Then, the ethical challenges of the cord blood bank were extracted from the results section using thematic content analysis. 22 studies were selected based on inclusion and exclusion criteria. The ethical challenges raised in the studies included private or public ownership of the bank, fair access to banking services, informed and voluntary consent, failure to provide sufficient information to individuals about the process, confidentiality of user's information, conflict of interest of bank founders (who are commonly doctors). The findings of this study indicated that there are serious ethical concerns regarding umbilical cord blood banks. Responding clearly to these ethical challenges calls for the attention of policymakers and medical ethics professionals; this will require a clear statement of the various aspects of these banks for society.
The relationship between vitamin D and spontaneous abortion among Iraqi women
Authors: Kasim Sumayah Faruq ,   1 College of Health and Medical Technologies, Middle Technical University, Baghdad, Iraq,   Sumayah Faruq Kasim, College of Health and Medical Technologies, Middle Technical University, Baghdad, Iraq. E-mail: sumayah.faruq@mtu.edu.iq
Published: November 2022

Miscarriage is the most common complication of pregnancy. Moreover, vitamin D deficiency is a prevalent concern among women of reproductive age, particularly in the Arab world, where the link between vitamin D deficiency and miscarriage is still unknown. This study was conducted to determine the relationship between vitamin D and miscarriage by comparing the concentration of vitamin D among women with spontaneous abortion and pregnant women. A total of 80 subjects were enrolled in this study and divided into two groups. The first group included 40 women with spontaneous abortions aged between 18 and 40 years. The second group included 40 pregnant women without previous history of miscarriages. Total 25-hydroxy vitamin D (25-OH-VD) measurement was estimated with a Dry Fluorescence Immunoassay analyzer using the Lansionbio LS-1100 instrument. The relationship between the five age groups and the vitamin D status of women with spontaneous abortion was not significant (p>0.05). There was no significant relationship between the miscarriage trimesters and vitamin D status (p>0.05) and between the five age groups (p>0.05). In our study, 95% of women with spontaneous abortion had vitamin D deficiency, compared to only 17.5% of pregnant women. A normal range of vitamin D improves the growth of the fetus and prevents pregnancy complications and miscarriage, promoting the growth of blood vessels in the placenta and improving the function of immune cells.
Arabian Levantine viper bite induces thrombocytopenia – a case report
Authors: Abukamar Ayman ,   1 Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan,   Ayman Abukamar, Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan. E-mail: aymanjor2020@hotmail.com, Abudalo Rawan ,   2 Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan, Odat Mazen ,   3 Department of Neurology Unit, King Hussein Medical City, Amman, Jordan, Al-Sarayreh Mohammad ,   1 Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan, Issa Maher Bani ,   1 Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan, Momanie Asem ,   1 Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan
Published: November 2022

Snakebites have been reported to induce hematological complications. Thrombocytopenia usually occurs secondary to disseminated intravascular coagulation (DIC) and coagulopathy induced by the snake bite. However, thrombocytopenia can develop after the snake bite, even in the absence of significant coagulopathy. We reported the case of a 36-year-old Jordanian male patient who was bitten by Arabian Macrovipera Lebetina Obtusa (Levantine viper), which developed venom-induced severe thrombocytopenia without coagulopathy. A progressive drop in platelet count was observed during his admission. His condition improved after anti-venom therapy, and he was discharged after 4 weeks of treatment for a full recovery. This case supports that snake venom can produce severe thrombocytopenia without significant coagulopathy, which can be treated successfully with anti-venom and the best supportive care.
An evaluation of clinical and ultrasound results of Pavlik harness treatment for developmental dysplasia of the hip
Authors: Mousavibaygei Seyed Rohallah ,   1 Department of Surgery, School of Medicine, Qom University of Medical Sciences, Qom, Iran, Karimnia Amir ,   2 Department of Orthopedic Surgery, Imam Reza Hospital, Urmia University of Medical Sciences, Urmia, Iran, Gerami Mohamad Hadi ,   3 Department of Orthopaedics, Bone and Joint Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Azadmehr Farhad ,   4 Department of Medical Surgical Nursing, Boukan Nursing Faculty, Urmia University of Medical Sciences, Urmia, Iran, Erfanifam Taher ,   5 Department of Surgery, Iran University of Medical Science, Tehran, Iran, Ghaedi Amin ,   6 Department of Orthopaedics and Traumatology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,   Amin Ghaedi, Department of Orthopaedics and Traumatology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: amin.ghaedi@gmail.com
Published: November 2022

Developmental dysplasia of the hip (DDH) is the instability or dislocation of the hip joint at birth that may occur in utero, during infancy, and childhood. This condition was identified as an important challenge. This study aimed to determine the clinical and ultrasound results of Pavlik harness treatment for DDH in patients referred to the pediatric clinic of Imam Khomeini Hospital in Ahvaz. This is a descriptive cross-sectional study in which 100 newborns aged 15 to 30 days were included by the census method after obtaining parental consent. Follow-up of the infants was performed at 3 and 6 months after treatment. All analyzes were performed using SPSS version 22 at a significance level of 0.05. The results showed that the mean age of the infants was 23.46±2.12 days, of which 33 infants were boys and 67 girls. The involvement on the right and left sides was 39% and 50%, respectively, and 11% of the infants had bilateral involvement. The mean value of acetabular index before placement was 25.48±6.509 and 26.38±3.866 on the right and left sides, which after 3 months of placement, was reduced to 21.62±2.578 and 21.57±2.839, respectively. Pavlik harness treatment was associated with acceptable radiological results in infants. This technique seems to be a suitable and applicable attempt to treat this problem and prevent serious and irreversible complications of late diagnosis.
Prevalence of hearing loss among patients with type 2 diabetes
Authors: Shafiepour Mohammadreza ,   1 Department of Internal Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Bamdad Zahra ,   2 Department of Otolaryngology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Radman Masoud ,   2 Department of Otolaryngology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Radman Masoud, Department of Otolaryngology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. E-mail: Masaodradman@yahoo.com
Published: November 2022

The auditory pathway is the main target for high levels of blood sugar. Increased glucose in diabetic patients can disrupt the auditory system physiologically and anatomically. The present study aimed to examine the prevalence of hearing loss in patients with type 2 diabetes. A total of 94 patients with type 2 diabetes, aged from 40 to 80 years, were selected randomly in the present descriptive cross-sectional study for pure tone audiometry (PTA), speech discrimination score (SDS), and speech reception threshold (SRT) tests. Accordingly, patients with a hearing threshold larger than or equal to 25 dB were considered hearing-impaired according to the PTA test. In addition, the patients' speech discrimination score was measured using a list of monosyllabic words with an intensity of 40 dB or more than the SDS test. However, in the SRT test, the patients' superficial speech comprehension threshold was measured using a list of two-syllable words. Most diabetic patients had hearing loss in both right and left ears based on the PTA and SRT tests. However, they did not have hearing loss in both ears according to the SDS test. There was no correlation between the PTA, SRT, and SDS tests and blood creatinine levels in both ears (p>0.05). Nevertheless, the right ear had a positive correlation with systolic blood pressure only in the PTA test (p<0.05). The difference between the two groups of men and women with type 2 diabetes in the hearing level in the right and left ears was not statistically significant. Hearing loss is a common deficiency in diabetic patients. In addition, it seems that diabetes is an independent risk factor for the hearing loss level.
The need for socket preservation: a systematic review
Authors: Alenazi Adel ,   Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia,   Adel Alenazi, Department of Oral and Maxillofacial Surgery and Diagnostic Science College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. E-mail: dradelpsauu@gmail.com, Abdullah Alotaibi Abdulrahman ,   Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia, Aljaeidi Yazaid ,   Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia, Raqe Alqhtani Nasser ,   Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
Published: November 2022

The aim of this study was to evaluate the clinical need and impact of socket preservation to protect the bone for future dental implant placement. Moreover, we aimed to list down various methods of socket preservation by going through randomized clinical trials. We searched PubMed, Google Scholar, and Cochrane databases for all relevant publications, where researchers compared various methods and tools for socket preservation. All eight randomized controlled trials mentioned several methods that are helpful in preserving bone levels both horizontally and vertically. The studies included in this systematic review demonstrate that each material has certain efficacy in preserving the socket after tooth extraction for future implant placement. Socket preservation methods and materials are effective in preparing patients for future prostheses.
The interplay between endometriosis and fertility in rats: a systematic review
Authors: Kanellopoulos Dimitrios ,   1 Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece,   2 Department of Obstetrics and Gynecology, Tzaneio Hospital, Athens, Greece,   Dimitrios Kanellopoulos, Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece. E-mail: drdimitrios8@gmail.com, Karagianni Dimitra ,   3 1st Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece, Pergialiotis Vasilios ,   1 Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece, Patsouras Grigorios ,   2 Department of Obstetrics and Gynecology, Tzaneio Hospital, Athens, Greece, Patsouras Konstantinos ,   2 Department of Obstetrics and Gynecology, Tzaneio Hospital, Athens, Greece, Nikiteas Nikolaos ,   4 2nd Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Athens, Greece, Lazaris Andreas C ,   3 1st Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece, Iliopoulos Dimitrios ,   1 Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece
Published: November 2022

For the last decades, endometriosis has been a major gynecological problem and a significant cause of infertility for women worldwide. It is estimated that the disease affects about 10–15% of all women of reproductive age and 70% of women suffering from chronic pelvic pain. At the same time, the incidence is about 40–60% in women with dysmenorrhea and 20–30% in women with subfertility. Despite the high percentage of affected women, endometriosis is still characterized by insufficient knowledge of the pathogenic processes, leading to the development and continuity of the disease. For this reason, there is a significant need for insight and understanding of the pathogenesis of endometriosis. This systematic review aims to present the latest data on the use of rats in endometriosis research and to explore how fertility is affected in rats with endometriosis. The methodology included a review of the available publications retrieved by a search in various scientific databases, such as PubMed, Scopus, Medline, and Google Scholar. The initial search generated 30 titles, with 10 articles fulfilling the inclusion criteria. In conclusion, several surgical techniques have been proposed to induce endometriosis, mainly using rats as the appropriate animal model. Studies in rats showed that endometriosis causes infertility and that pregnancy rates are lower for rats with endometriosis than those without endometriosis. In addition, rats with endometriosis have significant abnormalities in the structure of their oocytes as well as in the development of their embryos (genetic abnormalities).