bluuebunny/crossref_metadata_2025 huggingface dataset:
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Authors: Mastronikolis Nicholas S. , Delides Alexander , Kyrodimos Efthymios , Piperigkou Zoi , Spyropoulou Despoina , Giotakis Evangelos , Tsiambas Evangelos , Karamanos Nikos K.
Published: April 2024

The incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients’ genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper aerodigestive tract epithelium. The epidemiology, staging, diagnosis, and management techniques of head and neck squamous cell carcinoma (HNSCC), encompassing clinical, image-based, histopathological and molecular profiling, have been extensively reviewed. Lymph node metastasis (LNM) is a well-known predictive factor for HNSCC that initiates metastasis and significantly impacts HNSCC prognosis. Distant metastasis (DM) in HNSCC has been correlated to aberrant expression of cancer cell-derived cytokines and growth factors triggering abnormal activation of several signaling pathways that boost cancer cell aggressiveness. Recent advances in genetic profiling, understanding tumor microenvironment, oligometastatic disease, and immunotherapy have revolutionized treatment strategies and disease control. Future research may leverage genomics and proteomics to identify biomarkers aiding individualized HNSCC treatment. Understanding the molecular basis, genetic landscape, atypical signaling pathways, and tumor microenvironment have enhanced the comprehension of HNSCC molecular etiology. This critical review sheds light on regional and distant metastases in HNSCC, presenting major clinical and laboratory features, predictive biomarkers, and available therapeutic approaches.
Remote sensing and GIS-based inventory and analysis of the unprecedented 2021 forest fires in Türkiye’s history
Authors: Eker Remzi , Çınar Tunahan , Baysal İsmail , Aydın Abdurrahim
Published: April 2024

In the summer of 2021, Türkiye experienced unprecedented forest fire events. Throughout that fire season, a total of 291 fire incidents, covering an area of 202,361 hectares, dominated the public agenda. This study aimed to document and analyze the 30 large fires (affecting over 100 hectares) of 2021 using remote sensing and GIS techniques. A comprehensive fire database was established, encompassing information on burned areas, fire severity, and fuel types, determined from forest-stand types and topographical properties including slope, elevation, and aspect (in eight directions). Sentinel-2 satellite images were utilized to calculate dNBR values for assessing fire severity, analyzed in the Google Earth Engine platform. Three GIS-integrated Python scripts were developed to construct the fire database. In total, 164,658 hectares were affected by these large fires, occurring solely in three regions of Türkiye: the Mediterranean, Aegean, and Eastern Anatolian. The majority of the burned area was situated in the Mediterranean region (59%), with only 3% in Eastern Anatolia. The burned areas ranged from a minimum of 150 hectares to a maximum of 58,798 hectares. Additionally, 679 hectares of residential areas and 22,601 hectares of agricultural land were impacted by the fire events. For each fire, 21 fuel types and their distribution were determined. The most prevalent fire-prone class, “Pure Turkish pine species (Pr-Çz),” accounted for 59.56% of the total affected area (99,516 hectares). Another significant fire-prone pine species, the “Pure Black pine species (Pr-Çk),” covered 7.67% (12,811 hectares) of the affected area. Fuel types were evaluated by considering both forest-stand development stages and canopy closure. Regarding forest-stand development stages, the largest area percentage burned belonged to the “Mature” class (26.48%).
Adaptive strategies of high and low nucleic acid prokaryotes in response to declining resource availability and selective grazing by protozoa
Authors: Hu Chen , Yu Liuqian , Chen Xiaowei , Liu Jihua , Zhang Yao , Batt John , Xiao Xilin , Shi Qiang , Zhang Rui , Luo Tingwei , Jiao Nianzhi , Xu Dapeng
Published: April 2024

Prokaryotes play a fundamental role in global ocean biogeochemical cycles. However, how the abundance and metabolic activity of ecologically distinct subgroups (i.e., high nucleic acid (HNA) and low nucleic acid (LNA) cells), and their regulating factors, change in response to changing marine environmental conditions remains poorly understood. Here, we delved into the time-evolving dynamic responses of the HNA and LNA prokaryotic subgroups to declining resource availability and selective grazing by protozoa by conducting a 73-day incubation experiment in a large-volume (117,000 L) macrocosm that facilitates community-level exploration. We found that the metabolic activity of the HNA subgroup was higher than that of the LNA subgroup when the macrocosm was resource replete but that the HNA subgroup declined more rapidly than the LNA subgroup as the resources became increasingly scarce, leading to a steadily increasing contribution of LNA cells to prokaryotic activity. Meanwhile, as resources in the macrocosm became limited, protozoan grazing preference shifted from the HNA to the LNA subgroup and the contributions of the LNA subgroup to the carbon flow within the macrocosm increased. The findings highlight the resilience of LNA cells in resource-limited environments, illuminate the critical role of selective grazing by protozoa in balancing distinct prokaryotic subgroups under changing resource conditions, and demonstrate the complex and adaptive interactions between protozoa and prokaryotes across diverse environmental contexts.
Information-entropy enabled identifying topological photonic phase in real space
Authors: Ma Rui , Yan Qiuchen , Luo Yihao , Li Yandong , Wang Xingyuan , Lu Cuicui , Hu Xiaoyong , Gong Qihuang
Published: April 2024

The topological photonics plays an important role in the fields of fundamental physics and photonic devices. The traditional method of designing topological system is based on the momentum space, which is not a direct and convenient way to grasp the topological properties, especially for the perturbative structures or coupled systems. Here, we propose an interdisciplinary approach to study the topological systems in real space through combining the information entropy and topological photonics. As a proof of concept, the Kagome model has been analyzed with information entropy. We reveal that the bandgap closing does not correspond to the topological edge state disappearing. This method can be used to identify the topological phase conveniently and directly, even the systems with perturbations or couplings. As a promotional validation, Su–Schrieffer–Heeger model and the valley-Hall photonic crystal have also been studied based on the information entropy method. This work provides a method to study topological photonic phase based on information theory, and brings inspiration to analyze the physical properties by taking advantage of interdisciplinarity.

Graphical Abstract
The application of plant-exosome-like nanovesicles as improved drug delivery systems for cancer vaccines
Authors: Hillman Tatiana
Published: April 2024

The use of cancer immunotherapeutics is currently increasing. Cancer vaccines, as a form of immunotherapy, are gaining much attention in the medical community since specific tumor-antigens can activate immune cells to induce an anti-tumor immune response. However, the delivery of cancer vaccines presents many issues for research scientists when designing cancer treatments and requires further investigation. Nanoparticles, synthetic liposomes, bacterial vectors, viral particles, and mammalian exosomes have delivered cancer vaccines. In contrast, the use of many of these nanotechnologies produces many issues of cytotoxicity, immunogenicity, and rapid clearance by the mononuclear phagocyte system (MPS). Plant-exosome-like nanovesicles (PELNVs) can provide solutions for many of these challenges because they are innocuous and nonimmunogenic when delivering nanomedicines. Hence, this review will describe the potential use of PELNVs to deliver cancer vaccines. In this review, different approaches of cancer vaccine delivery will be detailed, the mechanism of oral vaccination for delivering cancer vaccines will be described, and the review will discuss the use of PELNVs as improved drug delivery systems for cancer vaccines via oral administration while also addressing the subsequent challenges for advancing their usage into the clinical setting.
Modelling and analysis of strength and durability properties of internal curing concrete using PEG 400 and artificial neural network
Authors: Gowdra Virupakshappa Sowjanya , Shrishail Basappa Anadinni , Thimmarayappa Mahadevaiah , Narayana Channa Keshava Naik , Buradi Abdulrajak , Emma Addisu Frinjo
Published: April 2024

The traditional curing processes necessitate a large amount of water. This is especially difficult in locations where there is a lack of water and for construction of high-rise structures. In this research article, we provide a remedy by inventing concrete that will not require additional water for curing. In the present work, polyethylene glycol was utilized as an internal curing agent in varying percentages. The internally cured concrete with polyethylene glycol was cured at ambient conditions, whereas the conventional concrete without polyethylene glycol was kept in water for curing. Fresh and hardened characteristics of concrete with and without polyethylene glycol are compared. The results revealed that 1.5% polyethylene glycol is an optimum percentage where maximum strength and durable properties are achieved. The microstructure of internal curing concrete indicates that the pore sizes are small compared to conventional concrete. The crystallite size is smaller in internal curing compared to conventional concrete mixtures, resulting in an acceleration of the hydration process in concrete with smaller crystallites.Further experimental results are compared with ANN. Predicted results are very close to experimental values.
Risk, perception and COVID-19 impact on food security: evidence from Bundelkhand region, India
Authors: Jatav Surendra Singh
Published: April 2024

This study assessed the implications of the COVID-19 pandemic on household food security in the Bundelkhand region of Uttar Pradesh, India. Macro data on 29 indicators was collected to identify food insecure districts, and after identification of most food insecure region, i.e. Bundelkhand region, micro data was collected from an intensive field survey. A multi-stage sampling technique was adopted to select study sites and respondents. A total of 240 sample households of various land sizes and income groups were contacted to collect data using a well-structured and pre-tested schedule. The study findings revealed that districts belonging to the Bundelkhand region are highly food insecure compared with other regions of Uttar Pradesh, India. Micro-level findings indicate that households in the Lalitpur district are relatively food insecure compared to those in the Jhansi district. The results suggest that ongoing future government responses should focus on structural changes in food security by developing responsive packages to cushion members pushed into food insecurity by such pandemics.
Towards human-AI collaborative urban science research enabled by pre-trained large language models
Authors: Fu Jiayi , Han Haoying , Su Xing , Fan Chao
Published: April 2024

Pre-trained large language models (PLMs) have the potential to support urban science research through content creation, information extraction, assisted programming, text classification, and other technical advances. In this research, we explored the opportunities, challenges, and prospects of PLMs in urban science research. Specifically, we discussed potential applications of PLMs to urban institution, urban space, urban information, and citizen behaviors research through seven examples using ChatGPT. We also examined the challenges of PLMs in urban science research from both technical and social perspectives. The prospects of the application of PLMs in urban science research were then proposed. We found that PLMs can effectively aid in understanding complex concepts in urban science, facilitate urban spatial form identification, assist in disaster monitoring, sense public sentiment and so on. They have expanded the breadth of urban research in terms of content, increased the depth and efficiency of the application of multi-source big data in urban research, and enhanced the interaction between urban research and other disciplines. At the same time, however, the applications of PLMs in urban science research face evident threats, such as technical limitations, security, privacy, and social bias. The development of fundamental models based on domain knowledge and human-AI collaboration may help improve PLMs to support urban science research in future.
COVID-19 outbreak and genomic investigation in an inpatient behavioral health unit
Authors: Rios-Guzman Estefany , Stancovici Alina G. , Simons Lacy M. , Barajas Grace , Glenn Katia , Weber Rachel T. , Ozer Egon A. , Lorenzo-Redondo Ramon , Hultquist Judd F. , Bolon Maureen K.
Published: April 2024

Background:

Inpatient behavioral health units (BHUs) had unique challenges in implementing interventions to mitigate coronavirus disease 2019 (COVID-19) transmission, in part due to socialization in BHU settings. The objective of this study was to identify the transmission routes and the efficacy of the mitigation strategies employed during a COVID-19 outbreak in an inpatient BHU during the Omicron surge from December 2021 to January 2022.

Methods:

An outbreak investigation was performed after identifying 2 COVID-19-positive BHU inpatients on December 16 and 20, 2021. Mitigation measures involved weekly point prevalence testing for all inpatients, healthcare workers (HCWs), and staff, followed by infection prevention mitigation measures and molecular surveillance. Whole-genome sequencing on a subset of COVID-19-positive individuals was performed to identify the outbreak source. Finally, an outbreak control sustainability plan was formulated for future BHU outbreak resurgences.

Results:

We identified 35 HCWs and 8 inpatients who tested positive in the BHU between December 16, 2021, and January 17, 2022. We generated severe acute respiratory coronavirus virus 2 (SARS-CoV-2) genomes from 15 HCWs and all inpatients. Phylogenetic analyses revealed 3 distinct but genetically related clusters: (1) an HCW and inpatient outbreak likely initiated by staff, (2) an HCW and inpatient outbreak likely initiated by an inpatient visitor, and (3) an HCW-only cluster initiated by staff.

Conclusions:

Distinct transmission clusters are consistent with multiple, independent SARS-CoV-2 introductions with further inpatient transmission occurring in communal settings. The implemented outbreak control plan comprised of enhanced personal protective equipment requirements, limited socialization, and molecular surveillance likely minimized disruptions to patient care as a model for future pandemics.
Magnetic resonance imaging respirators: a randomized crossover trial to assess respiratory protection, usability, and comfort
Authors: Williams Daryl Lindsay , Kave Benjamin , Bodas Charles , Roberts Megan , Ng Irene
Published: April 2024

Objective:

Many available facepiece filtering respirators contain ferromagnetic components, which may cause significant problems in the magnetic resonance imaging (MRI) environment. We conducted a randomized crossover trial to assess the effectiveness, usability, and comfort of 3 types of respirators, judged to be “conditionally MRI safe” with an aluminum nosepiece (Halyard 46727 duckbill-type respirators and Care Essentials MSK-002 bifold cup-type respirators) or “MRI safe” completely metal free (Eagle AG2200 semirigid cup-type respirators).

Design and setting:

We recruited 120 participants to undergo a quantitative fit test (QNFT) on each of the 3 respirators in a randomized order. Participants then completed a usability and comfort assessment of each respirator.

Results:

There were significant differences in the QNFT pass rates (51% for Halyard 46727, 73% for Care Essentials MSK-002, and 86% for Eagle AG2200, P < .001). The first-time fit test pass rate and overall fit factor were significantly higher for Eagle AG2200 compared with the other 2 respirators. Eagle AG2200 scored the lowest ratings in the ease of use and overall comfort. There were no significant differences in other modalities, including the seal rating, breathability, firmness, and overall assessment.

Conclusions:

Our study supports the utility of the Eagle AG2200 and Care Essentials MSK-002 respirators for healthcare professionals working in an MRI environment, based on their high QNFT pass rates and reasonably good overall usability and comfort scores. Eagle AG2200 is unique because of its metal-free construction. However, its comparatively lower usability and comfort ratings raise questions about practicality, which may be improved by greater user training.
Timing bombs and the temporal dynamics of Iranian nuclear security
Authors: Beasley Ryan K. , Mehvar Ameneh
Published: April 2024

For more than two decades, Iran’s nuclear programme has concerned policymakers and scholars alike. Whether speeding up uranium enrichment, slowing down international negotiations, or disrupting the timing of key initiatives, actions around Iran’s nuclear programme bear a clear time signature. Yet systematic accounts of the importance of time in shaping foreign and security policymaking have been largely neglected. Through foreign policy timing theory’s (FP4D) reconceptualisation of time we show how actors both constructed and then used time to pursue their strategic interests, creating, altering, and sabotaging the timing mechanism linking Iranian nuclear technology and international sanctions. These manipulations of time by both domestic and international actors resulted in prolonged international negotiations and fluctuating periods of crisis and produced a temporally flawed agreement frozen in time. We consider time’s impact on the current challenges and future direction of nuclear diplomacy with Iran as well as its importance for broader nuclear security issues.
Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue
Authors: De Sota Rhys E. , Quake Stephen R. , Sninsky John J. , Toden Shusuke
Published: April 2024

Despite gene-expression profiling being one of the most common methods to evaluate molecular dysregulation in tissues, the utilization of cell-free messenger RNA (cf-mRNA) as a blood-based non-invasive biomarker analyte has been limited compared to other RNA classes. Recent advancements in low-input RNA-sequencing and normalization techniques, however, have enabled characterization as well as accurate quantification of cf-mRNAs allowing direct pathological insights. The molecular profile of the cell-free transcriptome in multiple diseases has subsequently been characterized including, prenatal diseases, neurological disorders, liver diseases and cancers suggesting this biological compartment may serve as a disease agnostic platform. With mRNAs packaged in a myriad of extracellular vesicles and particles, these signals may be used to develop clinically actionable, non-invasive disease biomarkers. Here, we summarize the recent scientific developments of extracellular mRNA, biology of extracellular mRNA carriers, clinical utility of cf-mRNA as disease biomarkers, as well as proposed functions in cell and tissue pathophysiology.
The Chilean Christians for Socialism Movement: Liberationist, Third Worldist, and Utopian
Authors: Jashari Denisa
Published: April 2024

This article examines the emergence, consolidation, and influence of the Cristianos por el Socialismo (CpS, or Christians for Socialism) movement as part of the overlapping political and religious transformations of the 1960s. The election of self-declared Marxist Salvador Allende in 1970 inspired a sector of the clergy to creatively converge the tenets of Marxism and Christianity. The notion of transcendence and the construction of a “New Man” appealed to the utopian aspects of both religious and Marxist thinking. The Chilean CpS had a Latin American impact, as evidenced by the First Latin American Encounter of Christians for Socialism in Santiago in 1972, and a transnational impact, as seen in the formation of the Ecumenical Association of Third World Theologians in 1976. The analysis of CpS and its influence within and outside of Chile reveals an often-overlooked component of the Chilean road to socialism: the work of Catholics in Marxist-Christian rapprochement.
Barrow Necropolis from the 3rd and 2nd Millennia BC in Western Ukraine. A Bayesian Modeling and Isotopic Study
Authors: Makarowicz Przemysław , Goslar Tomasz , Szczepanek Anita , Yahodynska Maryna , Ilchyshyn Vasyl , Kozak Aleksandra , Romaniszyn Jan , Niebieszczański Jakub , Rud Vitalii , Pospieszny Łukasz
Published: April 2024

This article discusses the absolute chronology of burials from the 3rd and 2nd millennia BC discovered under the mounds of three barrows in the Kordyshiv cemetery in western Ukraine. Its aim is to create a chronological model of the burials by modeling 27 AMS 14C dates obtained from 21 individuals buried in single and collective graves. Dietary analysis of stable carbon (δ13C) and nitrogen (δ15N) isotope values are presented. The Bayesian modeling of the 14C dates from the three Kordyshiv barrows revealed the extremely important role of these monuments as long-term objects used for ritual purposes. At the end of the 3rd millennium BC, the epi-Corded Ware Culture (epi-CWC) community erected a mound over the central burial in Barrow 2, then interred the graves of three additional deceased. After several hundred years Barrow 2 was reused by Komarów Culture (KC) communities from the Middle Bronze Age (MBA) who interred their deceased in the existing mound. The oldest monument with MBA burials was Barrow 3, in which the dead were buried in a two-stage sequence before and after the mid-2nd millennium BC. The youngest dated grave was Burial 1 in Barrow 1, comprising a collective burial that was interred between 1400 and 1200 BC. The additional analyses of carbon and nitrogen isotopes show significant differences in the diet of epi-CWC individuals buried in Barrow 2 from the individuals representing the KC.
Comparing MICADAS Gas Source, Direct Carbonate, and Standard Graphite 14C Determinations of Biogenic Carbonate
Authors: Bright Jordon , Ebert Chris , Flores Carola , Harnik Paul G , Huntley John Warren , Kowalewski Michał , Portell Roger W , Retelle Michael , Schuur Edward A G , Kaufman Darrell S
Published: April 2024

Northern Arizona University, Flagstaff, Arizona, USA, recently installed a MIni CArbon DAting System (MICADAS) with a gas interface system (GIS) for determining the 14C content of CO2 gas released by the acid dissolution of biogenic carbonates. We compare 48 paired graphite, GIS, and direct carbonate 14C determinations of individual mollusk shells and echinoid tests. GIS sample sizes ranged between 0.5 and 1.5 mg and span 0.1 to 45.1 ka BP (n = 42). A reduced major axis regression shows a strong relationship between GIS and graphite percent Modern Carbon (pMC) values (m = 1.011; 95% CI [0.997–1.023], R2 = 0.999) that is superior to the relationship between the direct carbonate and graphite values (m = 0.978; 95% CI [0.959-0.999], R2 = 0.997). Sixty percent of GIS pMC values are within ±0.5 pMC of their graphite counterparts, compared to 26% of direct carbonate pMC values. The precision of GIS analyses is approximately ±70 14C yrs to 6.5 ka BP and decreases to approximately ±130 14C yrs at 12.5 ka BP. This precision is on par with direct carbonate and is approximately five times larger than for graphite. Six Plio-Pleistocene mollusk and echinoid samples yield finite ages when analyzed as direct carbonate but yield non-finite ages when analyzed as graphite or as GIS. Our results show that GIS 14C dating of biogenic carbonates is preferable to direct carbonate 14C dating and is an efficient alternative to standard graphite 14C dating when the precision of graphite 14C dating is not required.
Russian Invasion of Ukraine and Chinese Public Support for War
Authors: Aksoy Deniz , Enamorado Ted , Yang Tony Zirui
Published: April 2024

This study examines how the Russian invasion of Ukraine and the subsequent Western responses influence Chinese public opinion on the use of force. Using two original, preregistered online survey experiments, first in June 2022 and then in June 2023, we show that the Russian invasion is associated with a modest but statistically significant increase in Chinese support for using military force in international affairs in general and against Taiwan in particular. However, information on Western military measures aiding Ukraine curbs the modest impact of the invasion. Such information is especially effective in reducing support for an outright military invasion of Taiwan. Causal mediation analyses reveal that the Russian invasion influences public opinion by inducing optimism regarding military success and pessimism regarding peaceful resolution of the conflict. These findings suggest that foreign military aggression and subsequent international countermeasures can sway domestic public opinion on using military force.
Hybrid electrostatic waves in linearized gravity
Authors: Bhattacharjee Chinmoy , Stark David J.
Published: April 2024

Linearized gravity around a rotating black hole or compact object introduces the concept of a gravitomagnetic field, which originates from the matter–current in the rotating object. Plasma in proximity to this object is subsequently subjected to motion guided by this gravitomagnetic term (where mass serves as the effective charge) in addition to the conventional magnetic field. Such an interplay of fields complicates the accessible plasma waves of the system and thus merits exploration to delineate this interplay, to identify any observable signatures of the gravitomagnetic field in weakly magnetized systems, and to motivate future numerical work in a fully relativistic setting where the effects may be stronger. In this work we analyse the dispersion of the upper and lower hybrid electrostatic waves in a plasma immersed in both magnetic and gravitomagnetic fields. In particular, we discuss the effective augmentation or cancellation of the two fields under the right conditions for the upper hybrid wave. In contrast, the lower hybrid wave experiences a frequency up-shift from the gravitomagnetic field regardless of whether it is parallel or antiparallel to the magnetic field for the studied field strengths.
Scoping Arctic expertise: The mismatch between traditional theories of expertise and Indigenous expertise
Authors: Gricius Gabriella
Published: April 2024

While much work on expertise has explored the mobilisation and production of knowledge, the development of epistemic communities, and the mechanisms through which expertise operates – little work has been done exploring how expertise is understood across academic literature on particular regional cases such as the Arctic. In this article, I scope a broad literature review of the Arctic, seeking out how expertise has been depicted and framed in academic and theoretical literature. The results are framed around five different themes: (1) expertise serving the interests of great powers, (2) recognition of the overall importance of expertise in Arctic governance, (3) the purpose of experts, (4) science diplomacy and expertise: a murky barrier, and (5) how to study experts, but also find that Indigenous knowledge is often left out of literature that relies upon Western frameworks of expertise. This incongruity suggests that there are two competing conceptualizations of Arctic expertise, one in theory and another in practice – which has consequences for how the region and its expertise are narrated.
Afro-Brazilian religions and religious diversity: contributions to pluralism
Authors: Spica Marciano Adilio
Published: April 2024

My objective is to explore a possible contribution of Afro-Brazilian religions to a pluralist philosophy of religious diversity. I will especially explore the syncretic wisdom of these religious traditions, showing how it can help us better understand interreligious dynamics. To do this, I begin by exposing some challenges of pluralist theses, highlighting two problems: homogenization and isolationism. Following that, I briefly introduce some characteristics of Afro-Brazilian religiosity, emphasizing its syncretic aspects, and then argue in favour of syncretism as a kind of wisdom intrinsic to Afro-Brazilian religiosity. This wisdom encompasses both practical and conceptual aspects. I conclude by demonstrating how this Afro-Brazilian wisdom can contribute with philosophical studies on religious diversity.
Neural correlates of lexical-tone and vowel-quality processing in 6- and 9-month-old German-learning infants and adults
Authors: Götz Antonia , Männel Claudia , Schwarzer Gudrun , Krasotkina Anna , Höhle Barbara
Published: April 2024

We examined the neurophysiological underpinnings of lexical-tone and vowel-quality perception in learners of a non-tonal language. We tested 25 6- and 25 9-month-old German-learning infants, as well as 24 German adults and expected developmental differences for the two linguistic properties, as they are both carried by vowels, but have a different status in German. In adults, both lexical-tone and vowel-quality contrasts elicited mismatch negativities, with a stronger response to the vowel-quality contrast. Six-month-olds showed positive mismatch responses for lexical-tone and vowel-quality contrasts, with an emerging negative mismatch response for vowel-quality only. The negative mismatch responses became more pronounced for the vowel-quality contrast at 9 months, while the lexical-tone contrast elicited mainly positive mismatch responses. Our data reveal differential developmental changes in the processing of vowel properties that differ in their lexical relevance in the ambient language.
Understanding emotion dysregulation from infancy to toddlerhood with a multilevel perspective: The buffering effect of maternal sensitivity
Authors: Brown Mindy A. , Gao Mengyu (Miranda) , Isenhour Jennifer , Shakiba Nila , Crowell Sheila E. , Raby K. Lee , Conradt Elisabeth
Published: April 2024

Challenges with childhood emotion regulation may have origins in infancy and forecast later social and cognitive developmental delays, academic difficulties, and psychopathology. This study tested whether markers of emotion dysregulation in infancy predict emotion dysregulation in toddlerhood, and whether those associations depended on maternal sensitivity. When children (N = 111) were 7 months, baseline respiratory sinus arrhythmia (RSA), RSA withdrawal, and distress were collected during the Still Face Paradigm (SFP). Mothers’ reports of infant regulation and orientation and maternal sensitivity were also collected at that time. Mothers’ reports of toddlers’ dysregulation were collected at 18 months. A set of hierarchical regressions indicated that low baseline RSA and less change in RSA from baseline to stressor predicted greater dysregulation at 18 months, but only for infants who experienced low maternal sensitivity. Baseline RSA and RSA withdrawal were not significantly associated with later dysregulation for infants with highly sensitive mothers. Infants who exhibited low distress during the SFP and who had lower regulatory and orienting abilities at 7 months had higher dysregulation at 18 months regardless of maternal sensitivity. Altogether, these results suggest that risk for dysregulation in toddlerhood has biobehavioral origins in infancy but may be buffered by sensitive caregiving.
Design and fabrication of optically transparent transmitarrays using inkjet-printing technology
Authors: Chang Han , Lai Fei-Peng , Chen Yen-Sheng
Published: April 2024

This paper explores the use of inkjet-printing technology for transparent transmitarrays, presenting a viable alternative to traditional copper microwire counterparts. The study focuses on achieving high-gain performance crucial for wireless communication systems, with a particular emphasis on the fifth-generation (5G) millimeter-wave communication. Transparent transmitarrays leverage transparent conducting films and conductive mesh structures, overcoming opacity limitations and seamlessly integrating with urban architecture. In this paper, the inkjet-printing process is detailed for fabricating transmitarray apertures, highlighting the flexibility and precision in depositing nanosilver particles onto a glass substrate. The design intricacies involve optimizing feeding characteristics, determining unit cell structures, and constructing transmitarrays of various sizes. To validate the proposed technique, three different apertures (15 × 15, 20 × 20, and 25 × 25 unit cells) are constructed. The antenna performances are evaluated in terms of reflection coefficients, radiation efficiency, realized gain, and patterns, demonstrating the effectiveness of inkjet-printed transmitarrays. Comparative analysis with copper microwire counterparts is also conducted, validating the inkjet-printing technology for similar gain performance with added advantages of flexibility, compatibility with transparent substrates, and cost-effective manufacturing.
Development of KoRV-pseudotyped lentiviral vectors for efficient gene transfer into freshly isolated immune cells
Authors: Renner Alexander , Stahringer Anika , Ruppel Katharina Eva , Fricke Stephan , Koehl Ulrike , Schmiedel Dominik
Published: April 2024

Allogeneic cell therapies, such as those involving macrophages or Natural Killer (NK) cells, are of increasing interest for cancer immunotherapy. However, the current techniques for genetically modifying these cell types using lenti- or gamma-retroviral vectors present challenges, such as required cell pre-activation and inefficiency in transduction, which hinder the assessment of preclinical efficacy and clinical translation. In our study, we describe a novel lentiviral pseudotype based on the Koala Retrovirus (KoRV) envelope protein, which we identified based on homology to existing pseudotypes used in cell therapy. Unlike other pseudotyped viral vectors, this KoRV-based envelope demonstrates remarkable efficiency in transducing freshly isolated primary human NK cells directly from blood, as well as freshly obtained monocytes, which were differentiated to M1 macrophages as well as B cells from multiple donors, achieving up to 80% reporter gene expression within three days post-transduction. Importantly, KoRV-based transduction does not compromise the expression of crucial immune cell receptors, nor does it impair immune cell functionality, including NK cell viability, proliferation, cytotoxicity as well as phagocytosis of differentiated macrophages. Preserving immune cell functionality is pivotal for the success of cell-based therapeutics in treating various malignancies. By achieving high transduction rates of freshly isolated immune cells before expansion, our approach enables a streamlined and cost-effective automated production of off-the-shelf cell therapeutics, requiring fewer viral particles and less manufacturing steps. This breakthrough holds the potential to significantly reduce the time and resources required for producing e.g. NK cell therapeutics, expediting their availability to patients in need.
Slight drought during flowering period can improve Tartary buckwheat yield by regulating carbon and nitrogen metabolism
Authors: He Peiyun , Min Jiangyan , Tang Zhuolei , Yang Xue , Huang Kaifeng , Huang Xiaoyan
Published: April 2024

This study aimed to clarify the effects of drought during flowering period on the carbon and nitrogen metabolism, growth, and yield of Tartary buckwheat. Tartary buckwheat cultivar Jinqiao 2 was treated with well-watered (CK), slight soil-drought stress (LD), moderate soil-drought stress (MD), and severe soil-drought stress (SD), with the soil water potential maintained at − 0.02 to − 0.03, − 0.04 to − 0.05, − 0.05 to − 0.06, and − 0.06 to − 0.07 MPa, respectively. With prolonged growth period and an increase in drought stress, the antioxidant enzyme activities and the contents of substances and activities of enzymes related to carbon and nitrogen metabolism in Tartary buckwheat leaves initially increased and then decreased. Meanwhile, the contents of malondialdehyde and superoxide anion showed a continuous. LD treatment induced the highest antioxidant enzyme activities and the contents of substances and activities of enzymes related to carbon and nitrogen metabolism but the lowest contents of malondialdehyde and superoxide anion in Tartary buckwheat leaves. Compared with CK, LD treatment increased the grain number, 1000-grain weight (MTS), and yield per plant by 6.52%, 17.37%, and 12.35%, respectively. In summary, LD treatment can increase the antioxidant enzyme activities and the contents of substances and activities of enzymes related to carbon and nitrogen metabolism, thus enhancing the adaptability of Tartary buckwheat to drought stress and increasing the yield per plant.
Analysis for bioconvection due to magnetic induction of Casson nanoparticles subject to variable thermal conductivity
Authors: Almutairi D. K.
Published: April 2024

Owing to valuable significance of bioconvective transport phenomenon in interaction of nanoparticles, different applications are suggested in field of bio-technology, bio-fuels, fertilizers and soil sciences. It is well emphasized fact that thermal outcomes of nanofluids can be boosted under the consideration of various thermal sources. The aim of current research is to test the induction of induced magnetic force in bioconvective transport of non-Newtonian nanofluid. The rheological impact of non-Newtonian materials is observed by using Casson fluid with suspension of microorganisms. The chemical reaction effected are interpreted. The thermal conductivity of material is assumed to be fluctuated with temperature fluctuation. The flow pattern is endorsed by stretching surface following the stagnation point flow. Under the defined flow assumptions, the problem is formulated. A computational software with shooting technique is used to present the simulations. A comprehensive analysis for problem is presented. It is claimed that the interpretation of induced magnetic force exclusively enhanced the thermal phenomenon.
Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches
Authors: Islam Md. Rezaul , Islam Sovon Md. Shafiqul , Amena Ummy , Rahman Miadur , Hosen Md. Eram , Kumer Ajoy , Bourhia Mohammed , Bin Jardan Yousef A. , Ibenmoussa Samir , Wondmie Gezahign Fentahun
Published: April 2024

The pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery as well and structure-based drug design using huge chemical libraries are already widespread in the early stages of therapeutic and drug development. Here, various limonene derivatives are studied computationally for their potential utilization against the capsid protein of Herpes Simplex Virus-1. Firstly, limonene derivatives were designed by structural modification followed by conducting a molecular docking experiment against the capsid protein of Herpes Simplex Virus-1. In this research, the obtained molecular docking score exhibited better efficiency against the capsid protein of Herpes Simplex Virus-1 and hence we conducted further in silico investigation including molecular dynamic simulation, quantum calculation, and ADMET analysis. Molecular docking experiment has documented that Ligands 02 and 03 had much better binding affinities (− 7.4 kcal/mol and − 7.1 kcal/mol) to capsid protein of Herpes Simplex Virus-1 than Standard Acyclovir (− 6.5 kcal/mol). Upon further investigation, the binding affinities of primary limonene were observed to be slightly poor. But including the various functional groups also increases the affinities and capacity to prevent viral infection of the capsid protein of Herpes Simplex Virus-1. Then, the molecular dynamic simulation confirmed that the mentioned ligands might be stable during the formation of drug-protein complexes. Finally, the analysis of ADMET was essential in establishing them as safe and human-useable prospective chemicals. According to the present findings, limonene derivatives might be a promising candidate against the capsid protein of Herpes Simplex Virus-1 which ultimately inhibits Herpes Simplex Virus-induced encephalitis that causes interventions in brain inflammation. Our findings suggested further experimental screening to determine their practical value and utility.
Flexural failure properties of fiber-reinforced hybrid laminated beam subject to three-point bending
Authors: Tefera Getahun , Adali Sarp , Bright Glen
Published: April 2024

The present study investigates the flexural failure properties of a hybrid laminate beam subjected to three-point bending. A symmetrically laminated hybrid beam is constructed using high-strain and inexpensive glass fibre on the top layers and low-strain and expensive carbon fiber on the middle layers. Classical lamination plate theory is used to find the stress and strain distribution that occurs due to the bending moment on the compressive side. The theoretical failure limits of the laminated hybrid beam are analyzed considering the targeted span-to-depth ratios, volume fractions of the fibers and hybrid ratios using the Tsai-Wu failure criterion and Matlab codes. Using the graph of failure index versus hybrid ratios, the minimum thickness of carbon fiber needed for the delay of failure and cost efficiency of the laminated hybrid beam is identified by applying the linear interpolation method. The numerical results indicate that the failure index increases with the increasing loading span and decreases when the volume fraction of fiber increases. In particular, the placement of glass fiber on the top layer of the laminated hybrid beam might have contributed to obtaining higher strains and curvatures before the catastrophic failure properties of carbon fiber. The flexural stiffness of the laminates is found to increase when the hybrid ratio increases. Overall, it is noted that the theoretical analysis is one method that is less time-consuming and cost-effective than other alternative approaches, such as finite element methods and experimental tests to estimate the minimum thickness of high-stiffness and the expensive material needed to maintain the strength and stiffness of the hybrid composite structures over long periods.
Development of a nomogram for predicting in-hospital mortality in patients with liver cirrhosis and sepsis
Authors: Lin Hai-rong , Liao Qiu-xia , Lin Xin-xin , Zhou Ye , Lin Jian-dong , Xiao Xiong-jian
Published: April 2024

In this study, we aimed to investigate the risk factors associated with in-hospital mortality in patients with cirrhosis and sepsis, establish and validate the nomogram. This retrospective study included patients diagnosed with liver cirrhosis and sepsis in the Medical Information Mart for Intensive Care IV (MIMIC-IV). Models were compared by the area under the curve (AUC), integrated discriminant improvement (IDI), net reclassification index (NRI) and decision curve analysis (DCA). A total of 1,696 patients with cirrhosis and sepsis were included in the final cohort. Our final model included the following 9 variables: age, heartrate, total bilirubin (TBIL), glucose, sodium, anion gap (AG), fungal infections, mechanical ventilation, and vasopressin. The nomogram were constructed based on these variables. The AUC values of the nomograms were 0.805 (95% CI 0.776–0.833), which provided significantly higher discrimination compared to that of SOFA score [0.684 (95% CI 0.647–0.720)], MELD-Na [0.672 (95% CI 0.636–0.709)] and ABIC [0.674(95% CI 0.638–0.710)]. We established the first nomogram for predicting in-hospital mortality in patients with liver cirrhosis and sepsis based on these factors. This nomogram can performs well and facilitates clinicians to identify people at high risk of in-hospital mortality.
Use of a natural rock material as a precursor to inhibit corrosion of Ti alloy in an aggressive phosphoric acid medium
Authors: Fekry Amany M. , Filippova Inna V. , Medany Shymaa S. , Abdel-Gawad Soha A. , Filippov Lev O.
Published: April 2024

The mechanism of interaction between magnesite mineral and phosphoric acid (0.001–0.5 M) in addition to the determination of the protective properties for Ti alloy (working electrode) in phosphoric acid both with and without an inhibitor have been investigated by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization measurements. Results of electrochemical tests show that the corrosion resistance of titanium alloy in phosphoric acid solution only increased and hydrogen production decreased by either decreasing acid concentration or increasing immersion time associated with the thickening of the oxide film formed on the alloy surface. On adding magnesite, the corrosion resistance of Ti alloy is enhanced by increasing the phosphoric acid concentration (0.001–0.5 M) due to the formation of sparingly soluble magnesium phosphate film on the alloy surface that inhibits the effect of increasing hydrogen evolution reaction due to the pH value decreases. The increasing adsorption behavior of the magnesite inhibitor and decreasing its diffusion were deduced from EIS measurements. Thus, the addition of 3% magnesite minimizes the corrosion by forming a new protective film (Mg3(PO4)2), which differs from the traditional passive film and prevents the effect of the increase of hydrogen evolution. The surface morphology and chemical composition of the tested alloy were determined using scanning electron microscopy (SEM), Fourier transform Infra-Red spectroscopy (FTIR), X-ray diffraction (XRD), X-ray Fluorescence (XRF) and In situ Raman spectroscopy.
The impact of childhood trauma on emotional distress and the moderating role of sense of coherence among college students in China
Authors: Fan Ningdan , Fan Huanhuan , Luo Ruiqing , Wang Yu , Yan Yushun , Yang Xiao , Wang Min , Dou Yikai , Ni Rongjun , Wei Jinxue , Yang Wanqiu , Ma Xiaohong
Published: April 2024

Childhood trauma is strongly linked to emotional distress. However, few studies have explored the impact of sense of coherence (SOC) on the relationship between childhood trauma and emotional distress in college students. This study aimed to explore its impact on the relationship between childhood trauma and emotional distress. Analyzing data from 2307 Chinese college students, we found that SOC moderated the association between childhood trauma and anxiety/depression levels. Females showed higher SOC and lower anxiety/depression despite experiencing more childhood trauma. Multiple linear regression revealed that anxiety was negatively associated with SOC(P < 0.001) and grade(P = 0.027), and positively with childhood trauma(P < 0.001) and male gender(P = 0.004). Similarly, the depression exhibited similar associations. SOC moderated negatively the relationship between CTQ and anxiety, as well as between CTQ and depression. Childhood trauma is associated with increased emotional distress risk among college students, but a strong SOC can reduce this risk.