bluuebunny/crossref_metadata_2025 huggingface dataset:
Perspectives entourant la saisie de l’expérience enseignante lors d’incidents face-à-face pouvant perturber le climat de la classe
Authors: St-Pierre Joannie
Published: June 2019

L’accès aux savoirs en action reste un défi tant pour les professionnels eux-mêmes que pour les chercheurs. Dans le cadre de cet article, les incidents sont abordés puisqu’ils permettent de questionner les pratiques et les valeurs sous-jacentes à ces savoirs en action. L’objectif de cette contribution est donc d’explorer l’empan des possibilités associées à la saisie de l’expérience enseignante lors d’incidents. À la suite d’une recension des écrits sur les incidents, deux perspectives liées à la façon de saisir les schèmes ainsi que les indices guidant la perception semblent orienter les écrits. Certains se concentrent sur le traitement de l’information et considèrent la perception comme étant préalable à l’action. D’autres reconnaissent la perception de l’acteur, son ressenti et son intuition lors d’incident.

Mots-clés : incident; expérience; savoir professionnel; pensée enseignante; perception; recension des écrits.
CONSIDERACIONES ÉTICAS SOBRE EL USO DE ANIMALES NO HUMANOS EN INVESTIGACIÓN
Authors: Villela-Cortés Fabiola
Published: June 2019

La investigación por medio de modelos animales es una práctica que se ha realizado desde hace siglos. Su objetivo principal ha sido conocernos a nosotros mismos a través de ellos. El objetivo de este texto es cuestionar si la justificación metodológica implica una justificación ética que permite usar, dañar o matar animales no humanos en investigación para el beneficio humano. Para ello se revisarán algunos de los principales argumentos que permiten sostener que esta práctica es necesaria con la intención de refutarlos.
Clinicopathological Risk Factors Affecting Sexual Function after Radiotherapy for Cervical Cancer Patients
Authors: Y Harding , T Ooyama , S Ueda
Published: June 2019

Aim: To specify the clinicopathological risk factors that influence sexual function after radiotherapy for cervical cancer.Methods: This observational and cross-sectional study includes a population of 60 adult women diagnosed with stage I to III cervical cancer who underwent radiotherapy. Sexual function was assessed using a self-reported standardized questionnaire, the Female Sexual Function Index (FSFI). Age, clinical stage, tumor diameter, type of radiotherapy, use of hormone replacement therapy, and period of time elapsed since the completion of radiotherapy at the time of data collection were documented using participants’ medical records. Multivariate logistic regression was used to identify independent risk factors for decreased sexual function.Results: The median age of participants was 53 years (Interquartile range, IQR, 45-60 years). Using the FSFI total score compared by variable, sexual dysfunction was significantly more prevalent among women in FIGO stage III than those in stage I /II (P = 0.038), and at ≥ 12 months after the completion of radiotherapy than at < 12 months after completion (P = 0.008). Multivariate analysis revealed that sexual morbidity was significantly more likely in stage III women (OR 4.60, 95% CI, 1.07, 24.39, P = 0.040), or where radiotherapy had occurred more than 12 months before (OR 4.78, 95% CI, 1.17, 25.20, P = 0.028).Conclusion: FIGO stage III and a period of ≥ 12 months after radiotherapy are associated with reduced sexual function. In medical consultations with women in these categories, adequate treatment should be provided where appropriate.
Phase I/II Clinical Trial of Weekly Intraperitoneal Paclitaxel (IP-PTX) with Monthly Intravenous Carboplatin (IV-CBDCA) for Minimal Residual Disease of Ovarian, Tubal, and Peritoneal Carcinoma
Authors: S Takeuchi , Y Terai , K Tanimura , T Miyamoto , M Omichi , K Takeuchi
Published: June 2019

We conducted weekly intraperitoneal administration of paclitaxel (IP-PTX) with monthly intravenous administration of carboplatin (IV-CBDCA), as a prospective phase 1/2 setting. The purpose of this study was to assess the pharmacokinetics and to decide the recommended dose (RD) according to modified Fibonacci method. Patients aged 20-75 years old with histological confirmed mullerian cancers (epithelial ovarian cancer; EOC, fallopian tubal cancer; FTC, and primary peritoneal cancer; PPC) from stage IC to IV or the patients with recurrent disease with small residual disease (including retention of ascetic fluid, para-aortic nodes recurrence after optimal debulked after interval debulking surgery; IDS) were eligible. The protocol regimen consisted of IP-PTX on day1 (D1), 8, and 15, at a starting dose level 1(DL1) of 45 mg/m2, with 15 mg/ m2 incremental, and IV-CBDCA was fixed dose AUC 5.0 mg/mL.min on D1, monthly. The accrual period was from August 2000 until September 2005. As for result, twelve patients were enrolled. No dose limiting toxicity (DLT) was observed in DL1. In dose level 2 (DL2, 60 mg/m2), one grade 3 (G3) hypersensitive reaction to CBDCA was detected. Further 5 patients had been enrolled but additional DLT was not identified. The RD was decided as DL2, which was the same dose of RD in weekly IP-PTX reported by Francis et al. The serum AUCs of PTX in DL1 and DL2 were 1605 nM.min and 2365 nM.min, respectively. By serum CA125, five complete responses were observed out of 8 evaluable patients by Rustin’s criteria. In conclusion, the combination of weekly IP-PTX and monthly IV-CBDCA at AUC 5.0 mg/mL.min was feasible and the recommended dose of IP-PTX was 60 mg/m2. The therapy was moderate effective for optimal debulking mullerian carcinomas. From our pharmacokinetic results, as for the patients with extra-pelvic lesions, additional IV-PTX would be necessary like GOG 172 experimental arm.
500 Years after the Great Battles
Authors: Vaughan R.
Published: June 2019

Not available.
De grenzen van de koloniale geschiedenis
Authors: Goor J. van
Published: June 2019

W.Ph. Coolhaas, A critical survey of studies on Dutch colonial history
Een welkom en goed naslagwerk
Authors: Bornewasser J.A.
Published: June 2019

J. Charité, Biografisch woordenboek van Nederland
Byatt, Fiction and Biofiction
Authors: Saunders Max
Published: June 2019

A. S. Byatt’s fiction is much possessed by ‘lives’ – not only the lives of her characters, but the ideas of the biographies of those characters, and of characters as biographers. The essay will explore the relation between fiction, biography and autobiography in her work, taking in such topics as portraiture, myth, creation and reading. It will ask why a novelist who has written about earlier historical periods has eschewed one of the defining devices of the historical novel – and postmodern biofiction – of using real historical figures as characters.
Socio-Economic Factors influencing Entrepreneurship Development: An Empirical study across the Small & Medium Enterprises of Chennai, State of Tamil Nadu, India
Authors: Khan Firdouse Rahman
Published: June 2019

Entrepreneurship Development makes a powerful impact on the economic development of the country. The success of the entrepreneur depends on the environmental factors such as social, economic, legal, political and technological factors which influence their activities thus leading to successful entrepreneurship. The socio-economic factors are the major key factors influencing the entrepreneurial behavior and operation of the business and thus the need for the study and the due influence. This paper analyzes the impact of socio-economic factors in relevance to entrepreneurship development of Small and Medium Enterprises (SMEs) across Chennai, Tamil Nadu State, India.This paper attempts to explain the infrastructure that has to be developed in order to cultivate the quality of leadership among potential enterprising young men. Attempts are being made to inculcate the spirit of entrepreneurship. Our empirical results reveal that most of the selected entrepreneurs of SMEs perceive the relevance of these factors to the highest degree. They are tempted to enter the entrepreneurship sector because of the perceived opportunities available to make an appreciable profit.The study also reveals that the factors which are not considered to be of high importance in the bygone days, such as Education, Religion, Previous Experience, Family Type and Legal Status have a significant influence on the entrepreneurial behavior and the operational performance of the selected SMEs’ business, in the recent period. Thus, there exists a necessity for the Government and the related sponsoring institutions to look into these factors and encourage the young entrepreneurs who in turn will render their full support towards national economy.
REGENERATION SYSTEM OF LETTUCE (LACTUCA SATIVA L.) THROUGH IN VITRO CULTURE
Authors: Romanova O. V. , Soldatenko A. V. , Romanov V. S.
Published: June 2019

The article is devoted to the problem of obtaining regenerative plant varieties of lettuce (Lactuca sativaL.) Bouquet, Emerald, Chameleon (FSBSI Federal Scientific Vegetable Center). Salad culture is insensitive toin vitroconditions and requires the development of alternative regeneration conditions. Seeds were surface sterilized in 96% ethanol (30 s), then 15 minutes in 50% aqueous solution of "Whiteness" with the addition of Twin-20 (1 drop per 100 ml), washed three times in sterile distilled water. Then lettuce seeds were placed in Petri dishes on Gamborg B5 medium (2% sucrose, 3,0 g/l fitogeli). After 10 days, the obtained seedlings were cut, the leaf blades were cut into squares 1 cm in size and transferred to medium MS B5 (2% sucrose) with three variants of hormone concentrations: 0.1 mg/l NAA and 1 mg/l BAP, 1 mg/l NAA and 1 mg/l BAP, 1 mg/l NAA and 0.1 mg/l BAP. The formed shoots were rooted on MS medium (2% sucrose, 7,0 g/l agar). Cultivation was carried out on racks with fluorescent lamps at 25°C and a photoperiod of 14 hours, illumination of 2,5 thousand Lux. According to the results of studies, the concentration of hormones (0,1 mg/l NAA, 1 mg/l BAP) was selected, which allowed to obtain up to 10 shoots from one leaf explant. Moreover, the largest number of shoots was noted on leaf explants located closer to the veins of the sheet. The obtained data allowed to improve the system of regeneration of varieties of emerald lettuce, Bouquet and Chameleon.
STUDY OF PERSPECTIVE BASIL VARIETIES AS SOURCES IN SELECTION ON PRODUCTIVITY AND PRECOCITY IN THE CONDITIONS OF SOUTH RUSSIA
Authors: Novikova L. N. , Novikov B. N.
Published: June 2019

Few vegetable plants are a source of necessary biologically active substances. Special significance is given to spicy cultures, the most common among which is basil gardening (Ocimum basilicum L.). Its plants, possessing a rich and diverse chemical composition, are used in the medical and food industry, fresh and as components of spice mixtures to improve the quality of food. However, the basil culture is not widely spread and its use is limited. To increase the demand and consumption of this vegetable crop, the creation of promising varieties that meet modern market requirements is relevant. At the same time, it is necessary to search for sources of economically valuable traits - productivity, precocity and yield. The aim of the study was to study the collection variety samples of basil and the selection of sources of valuable features for use in breeding work. The initial material served as 72 samples of this culture of various ecological and geographical origin from the VIR collection. In the phase of mass flowering, they differ as early flowering, medium flowering and late flowering. In the phase of ripening seeds – early ripening, mid-ripening and late ripening. Selected sources of valuable features are recommended as a starting material for the selection of garden basil (Ocimum basilicum L.).
PRODUCTIVITY OF HYSSOPUS OFFICINALIS ON DROPPED IRRIGATION IN SOUTHERN STEPPE OF UKRAINE
Authors: Andreychenko L. V. , Kovalenko O. A.
Published: June 2019

Researches conducted on lands Nikolayev state agricultural research station IIA NAAS in 2017- 2018. Soil of an experimental plot is chernozem southern weakly eroded clay loamy on loess’s, it is noted by high contents potassium, average – phosphorus and it is not enough provided by nitrogen. Climate of region – continental, is characterized sharp and repeated by fluctuations annual and month temperature of air, greater spare of heat and aridity. Agrotechnic in experiment was generally accepted for southern Steppe of Ukraine. Scheme of experience included three factors – a sowing periods: II ten-day period of October (winter), II ten-day period of November (underwinter), I ten-day period of April (spring); variants of fertilizers: without fertilizers (control), recommended dose (N60P60) and N30Р30 broadcast + N30Р30 with irrigated water; the modes of irrigation: 80-70-70% of minimum moisture-holding capacity and 90-80-70% of minimum moisture-holding capacity. It is shown that hyssop – valuable spicy-aromatic culture, which on their own biological particularity, requirements to soil-climatic conditions can be successfully grown in southern Steppe of Ukraine, providing high harvest of floral mass for use in medical pharmacology. Most productivity variety Marquis (at a rate of 28.4-28.5 c/hа dry cheese) provided in variant, where contributed 50% dose of fertilizers broadcast and 50% with irrigated water and winter sowing period of culture. Maximum contents of essential oil has fixed in same variant at mode irrigation 80-70-70% of minimum moisture-holding capacity, where it has formed 0.85 %. Contents of ascorbic acid in plant raw material varied from 100.4 before 104.9 mg%.
Bargaining Problem: Does Disagreement Point Result from Value Control or Value Deprivation? or, Does Value Control (or Value Deprivation) Result from Disagreement?- A Win-Win-Win Papakonstantinidis Approach
Authors: Papakonstantinidis Leonidas
Published: June 2019

The article concerns the Convergence policy as a prospect for the future economic view, as it deals with the value deprivation. Value deprivation arises due to the lack of goods-values which are available to a higher economic class of consumers as a point of disagreement in a cause-effect relationship or even vice versa, within a huge bargain between 2 having opposing interests, as the result of value control. State of deprivation, Value destruction, and disagreement point are examined separately, and so is the methodological tool, called the “win-win-win Papakonstantinidis model” intended for investigating the impact of the value control to the disagreement point I. Value destruction can be turned into a Value creating opportunity. thus the disagreement point. The win-win-win Papakonstantinidis model is used as a methodological tool for examining the impact of the control value to the disagreement point. A strong correlation between disagreement and value control is found, through the research on 30 CEO’s all over Europe
Entre fantasmas y fotografía: una alianza histórica en vías de transformarse
Authors: Linhares Sanz Claudia , De Souza Fabiane
Published: June 2019

En la modernidad, la popularidad de los fantasmas se consolida como síntoma de ciertos modos de narrar la historia y de vivir el tiempo. Las tecnologías modernas impulsan un nuevo dominio de los seres que regresan: se trata de una reorganización del campo de lo visible en que la fotografía interviene como positividad, desplazando y reorganizando la experiencia de las imágenes. Por el hecho de nunca estar completamente en el pasado o en el presente, las fotografías se constituyeron como seres tan inestables como los fantasmas. ¿Serían, sin embargo, los mismos fantasmas que nos asombran hoy?
“El nudo matrimonial que con vos, mi señora, me ha hecho uno”: el curioso carácter doméstico/conyugal de la poesía amorosa de Eugenio de Salazar
Authors: Locke Jessica C.
Published: June 2019

Este artículo se enfoca en la poesía amorosa de Eugenio de Salazar (1530-1602), toda la cual —a lo largo de los 180 folios de la primera parte de su Silva de poesía— está dedicada a su esposa, doña Catalina Carrillo. Se muestra que esto representa una desviación significativa del modelo petrarquista, en el que la musa/amada es, fundamentalmente, una figura inalcanzable, y se considera la manera en que el carácter doméstico/conyugal de su poesía le permite al autor introducir ingeniosas variaciones en el género amoroso-cortesano. Específicamente, se analizan dos series poéticas de la primera parte de la Silva con el fin de ejemplificar la gran originalidad que caracteriza el tratamiento por parte de Salazar de temas convencionales en la poesía amatoria de corte petrarquista.
THE EFFECT OF PREGNANT MOTHER’S BEHAVIOR IN THE PRE-PURCHASE STAGE TOWARDS THE SELECTION OF BIRTHPLACE
Authors: Aprilia Rika , Effendy Novita Aulia , Nisa Feni Choirun , Wulandari Ratna Dwi
Published: June 2019

Background: A preliminary study at Mother and Child Hospital of Nyai Ageng Pinatih, Gresik, showed a gap between the number of pregnant women conducting antenatal examinations and the number of deliveries at the hospital in 2011. The number of pregnant women visits for antenatal care was relatively high. It is known that the average number of pregnant mothers giving birth at Mother and Child Hospital of Nyai Ageng Pinatih in 2011 was only 53.85%.  Aims: This study aimed to analyse the effect of maternal behaviour on the pre-purchasing stage during pregnancy in choosing a birth location.Methods: This research was an analytical study with a cross sectional design. The population of this study was 235 mothers who completed the antenatal care at Mother and Child Hospital of Nyai Ageng Pinatih and were predicted to give birth around March to May 2012. The sample size was 75 people determined by using a cluster sampling method. Each independent variable was tested by identifying the influence on the choice of birth location by using univariate logistic regression with α value of <0.05.  Results: The results of this study indicated that maternal behaviour in the pre-purchasing stage of delivery services consists of 3 stages (identification of needs, information seeking, and evaluation of alternatives) that influence the choice of birth place by pregnant mothers. It showed that the pre- purchasing stage has an impact on the choice of delivery place.Conclusions: The mother's behavior at the pre-purchasing stage during pregnancy influences the choice of delivery place inside and outside Mother and Child Hospital of Nyai Ageng Pinatih. Providing information about maternity care and delivery services can promote services provided at the hospital. The hospital should provide brochures about available services, post posters about health service options available, and promote delivery services conducted by obstetricians or midwives as an alternative delivery service. Keywords: Mother’s behaviour, Pre-purchasing stage, Selection of delivery location.
The Use of Destructive and non Destructive Testing in Concrete Strength Assessment for a School Building
Authors: Minutolo Vincenzo , Di Ronza Stefania , Eramo Caterina , Zona Renato
Published: June 2019

The present paper aims to increase knowlodge of the methods of resistance estimating of concrete in situ by means of non-destructive tests used to integrate the quantitative results from cylindrical specimens (core). The results of experimental investigations carried out on concrete conglomerate samples of a school building are shown. The experimental campaign then will be presented like a case study, conducted on a series of concrete beams and pillars of an existing building. The distructive tests on cores were conducted at the Civil Structures Laboratory of the Engineering Department of the University of Campania "Luigi Vanvitelli". The expression obtained through the calibration procedure of the values of non-destructive tests with those provided by the core drills allowed to estimate the average values of the compressive strength of the concrete. It is highlighted how this result was achieved with a very limited core number provided that they are extracted in selected points and that there was a proportionality link with the resistances obtained from non distructive tests.
Using the Context, Input, Process and Product (CIPP) Model in the Evaluation of Training Programs
Authors: Umam Khalif Ashhabul , Saripah Iip
Published: June 2019

Evaluation of training program is made to establish the achievement of program objectives and to provide recommendations for program improvements. In this article, use of the CIPP (Context, Input, Process, and Product) evaluation model in training programs is discussed. It is an evaluation research, with a descriptive quantitative approach involving 16 training program participants as research subjects. The data collection techniques were based on questionnaires as the main instrument, with interview guides and observation guidelines as supporting instruments. The data analysis was made by comparing the scores obtained with the ideal score and multiplying by 100%; the results of these calculations were then grouped into a number of criteria that had been established. The results of the study indicate that the context dimension consisting of training objectives, training needs assessment, and state agency program organizers obtained a PE (Percentage of Effectiveness) score of 75.04%, placing it in the "fair" criterion. In the input dimension, consisting of participant description , instructor condition, infrastructure, training curriculum and instructional media, the PE score was 79.44% again in the "fair" criterion. In the process dimension, comprising lecture method, discussion method, demonstration method, question and answer method, practice method, field visiting method and evaluation of learning outcomes, the PE score obtained was 78.75%, which was also in the "fair" criterion. Finally, in the product dimension of knowledge aspect, attitude aspect and skill aspect, the PE score was 82.29%, in the “good" criterion. Based on the results of the dimension evaluation, the total PE score obtained was 78.88%, or overall in the "fair" criterion. It can be concluded that in general the execution of this training program was successful, so it is recommended that similar programs be conducted again, with some improvements.
Beliefs: Quality Teaching Practicum Vs Quality Teachers
Authors: Choo Gui Chan , Yunus Md Melor , EMBI MOHAMED AMIN
Published: June 2019

Teaching practicum is one of the important aspects in teacher education programme as it concerns preparation of quality teachers and it embraces all the learning experiences of pre-service teachers in schools. Teaching practicum is a real challenge for the pre-service teachers because their performance during teaching practicum will foreshadow the future success of the pre-service teachers. Therefore, the aim of this paper is to investigate Teaching English as a Second Language (TESL) pre-service teachers’ beliefs about teaching practicum and identify what components of teacher education programme that contribute pre-service teachers’ views about teaching practicum. Data was collected via a questionnaire survey of third year TESL undergraduates from University of Malaya. The data was analyzed using descriptive statistics. The findings will be presented and elaborated upon in this paper. For further understanding, this paper also discusses the pre-service teachers’ beliefs according to the two main aspects namely, (i) importance of teaching practicum and (ii) confidence and uncertainty about teaching practicum.
PENGARUH PENAMBAHAN SERAT LIMBAH BANNER TERHADAP KUAT LEKAT DAN MIKROSTRUKTUR BETON SERAT PASCA BAKAR SEBAGAI SUPLEMEN BAHAN AJAR MATA KULIAH TEKNOLOGI BETON
Authors: Rahmawati Anis
Published: June 2019

The purpose of this study, 1) know how the addition of fiber length variation of banners and combustion temperature variations to bond strength post-burn concrete, 2) know the change of microstructures of concrete by the addition of fiber the waste banner on some variations of the length of the fiber and temperature variations pre and post-burn, 3) know optimum value the addition of fiber waste banner that will produce concrete with bond strength post-burn concrete maximum.This research using quantitative research methods with experimental approach. Variables that affect in this study is 1) free variables include the addition of long fiber waste banner that is 3 cm, 6 cm, 9 cm and in the amount of 0.2% of the weight of the concrete and the temperature variation of combustion that is room temperature (28 ˚ C), 200 ˚ C ˚ C, 300, and 400 ˚ C, 2) variable bound to include bond strength and microstructures of concrete due to variations in the length of the fiber waste banner and combustion temperature variations. Research results as follows 1) addition of long fiber waste banner resulting in a decrease in the temperature of 300 ˚ C and rise at a temperature of 400 ˚ C, 2) change in microstructures of concrete with addition of waste fiber banner on some variations of the length of the fiber and combustion temperature variations can be seen from the pores and cracks in the concrete post-burn that looks more than concrete pre-burn, 3) addition of long fiber waste banner that generates maximum value bond strength the concrete post-burn occurred at the addition of long fiber waste banner 3 cm with combustion temperatures 200 ˚ C.
Injustice during Night Work for Female Employees: A Lesson from Samarinda, Indonesia
Authors: Pratama Rio Arif , Prasetyo Bayu , Mubarok Asnawi , Muslim Ikhwanul
Published: June 2019

Night working rules are legal provisions that give rights to female workers who work from 23:00 p.m.to 07:00 a.m.provided by employers. Night working rules for women have certain characteristics of potential hazards which are different from other profession. This study aims to determine the effectiveness of night working rules for female workers in Samarinda City. The specific target to be achieved in this study is to identify company that employs female workers from 23:00 p.m. to 07:00 a.m. and to review the role of labor inspectors in enforcing night working rules for female workers in Samarinda City. The method of this study is empirical legal research method which is analyzed qualitatively. The results of the study will be described analytically. The results of this study found that there were many violations of the night working rules, besides that female workers did not know what rights they should have gotten from their employers. The role of labor inspectors is still ineffective, even in some places there were some companies which night working rules had not been supervised by labor inspector. The implications of this research will be submitted to the Department of Manpower and Transmigration of East Kalimantan Province as a contribution of research information on the effectiveness of night working rules for female workers in Samarinda City.
Robust Nonlinear Newton Solver With Adaptive Interface-Localized Trust Regions
Authors: Klemetsdal Øystein S. , Møyner Olav , Lie Knut-Andreas
Published: June 2019

The interplay of multiphase-flow effects and pressure/volume/temperature behavior encountered in reservoir simulations often provides strongly coupled nonlinear systems that are challenging to solve numerically. In a sequentially implicit method, many of the essential nonlinearities are associated with the transport equation, and convergence failure for the Newton solver is often caused by steps that pass inflection points and discontinuities in the fractional-flow functions. The industry-standard approach is to heuristically chop timesteps and/or dampen updates suggested by the Newton solver if these exceed a predefined limit. Alternatively, one can use trust regions (TRs) to determine safe updates that stay within regions that have the same curvature for numerical flux. This approach has previously been shown to give unconditional convergence for polymer- and waterflooding problems, also when property curves have kinks or near-discontinuous behavior. Although unconditionally convergent, this method tends to be overly restrictive. Herein, we show how the detection of oscillations in the Newton updates can be used to adaptively switch on and off TRs, resulting in a less-restrictive method better suited for realistic reservoir simulations. We demonstrate the performance of the method for a series of challenging test cases ranging from conceptual 2D setups to realistic (and publicly available) geomodels such as the Norne Field and the recent Olympus model from the Integrated Systems Approach for Petroleum Production (ISAPP) optimization challenge.
Evaluation of vision-related quality of life with autologous internal limiting membrane transplantation for refractory macular hole.
Authors: Yuan Dongqing , Zhang Weiwei , Yuan Songtao , Xie Ping , Liu Qinghuai
Published: June 2019

Background: To evaluate the vision-related quality of life of vitrectomy combined with autologous internal limiting membrane(ILM) transplantation for refractory macular hole．
Methods: A prospective and nonrandomized clinical study was carried out. There were fourty eyes with refractory macular hole included and all eyes received 23G vitrectomy and ILM peeling with autologous ILM transplantation. Preoperative and postoperative basic conditions were recorded, including best corrected visual acuity (BCVA), intraocular pressure, central retinal thickness (CRT) measurement by Optical coherence tomography (OCT) examination, macular hole index (MHI) and operative complications. The Chinese version of visual-related quality of life scale -25 (CVRQoL-25) was used to evaluate the visual related quality of life of patients after operation. The correlation between the quality of life and the postoperative visual acuity and the size of the macular hole before operation was tested by Spearman rank correlation test.
Results: All patients were followed up for three months after surgery, and 38 patients achieved anatomical closure. The mean postoperative logMAR BCVA was 1.09±0.33, which has significantly improved than that before operation (P=0.000). The vision-related quality of life of patients after surgery was closely related to the macular hole index (r=0.375, P=0.017), but was negatively correlated with the best corrected visual acuity before and after surgery (r=-0.495, P=0.001; r=-0.760，P=0.000). It was also found that the vision-related quality of life of patients positively correlated with the postoperative CRT ( r=0.414，P=0.008).
Conclusions: The anatomical structure of refractory macular hole patients with ILM peeling combined with autologous ILM transplantation was largely reduced, and the visual acuity of the patients improved significantly. Meanwhile, the vision-related quality of life was significantly improved after surgery.
Trial Registration: ChiCTR-INR-16008660, date of registration: 2016/06/17
Identification of risk factors associated with developing ocular ischemia syndrome in patients with carotid artery occlusion
Authors: Huang Minhui , Han Ning , Wu Yazhen , Gao Zhonghai , Zhang Zhenlong , Huang Shan
Published: June 2019

Prupose

This study aims to explore risk factorsassociated with ocular ischemia syndrome (OIS) in patients with late stage carotid artery occlusion (CAO). Methods Eighty-seven patients with CAO were enrolled and examined via patient history questionnaire, carotid duplex ultrasonography,transcranial doppler sonography (TCD) and eye examination (slit lamp, ophthalmoscopes). Results Twenty-two patients were diagnosed with OIS. Female patients are more likely to development OIS (OR=2.78). Patients without collateral circulation were associated with risk of OIS (OR=4.245, P<0.05). Conclusions One quarter of patients with CAO patients had OIS and sex and non-collateral circulation building were associated with OIS.
Frequency of non alcoholic fatty liver in helicobacter pylori infected dyspeptic patients, is it a far reaching implication?
Authors: Siddiqui Hafiz Abdul Basit , Azmat Rabeea , Yakoob Javed , Abbas Zaigham , Tikmani Shiyam Sunder , Mushtaq Zain , Zafar Saad Bin , Khan Muhammad Tahir
Published: June 2019

Background: Fatty infiltration of the liver represents the intracytoplasmatic accumulation of triglycerides in the hepatocytes. We determined if H. pylori infection contributes to fatty liver infiltration and if it was related to gastric mucosal changes. As fatty liver disease is seen prevalent in non obese non alcohol consuming population of some asian countries.
Methods: This cross-sectional study conducted between 22/11/2016 to 30/06/2018 in the Department of Medicine Aga Khan University Hospital. Eligible patients were enrolled after taking informed consent. Sociodemographic data were collected on age, gender, smoking and alcohol use, along with medical history related to dyslipidemia, hypertension, Type 2 diabetes mellitus, and ischemic heart disease. Fatty liver infiltrations were assessed using ultrasonography. H.pylori infection was detected by using carbon urea breath test (14C-UBT).
Results: A total of 698 patients were enrolled during the study period with a mean age of 44.01±16.03 years and male patients were 373 (53%). A total of x patients were present with dyspepsia of the 299 (57%) of the patients were found to have positive H. pylori test. Of 299 patients with positive H. pylori test, 153 (20%) of the patients were diagnosed as having fatty liver infiltrations. H. pylori infection induced chronic active gastritis was associated with fatty liver infiltration in 62(71%) and absent in 200(64%) (P= 0.264).
Conclusion: The frequency of fatty liver infiltration in Helicobacter Pylori infected dyspeptic patients was 20%. Age and BMI are associated with fatty liver among dyspeptic H. pylori patients.
Keywords: H. pylori, Fatty liver, BMI > 23; Type 2 diabetes. This is due to the incorporation of proinflammatory cytokines by the helicobacter pylori and its impact on gut microbiota leading to leaky gut and GUT-LIVER-AXIS interaction at different levels. Despite low BMI in our population, fatty liver is seen in connection with helicobacter pylori related gastric mucosal inflammation.
Mid-term results of an anterior ilioischial plating for complex acetabular fractures with a combined anterior approach: a retrospective cohort study
Authors: Meng Weikun , Ou Yi , Wu Zhaoxiang , Yang Hongchang , Chen Ge , Bi Xin , Gao Liang , Chen Zhong
Published: June 2019

Background: Bi-columnar plating via combined anterior and posterior approaches is routinely applied treatment for complex acetabular fractures with noteworthy shortcomings. The goal of this study was to evaluate the effectiveness of the anterior plating with an ilioischial plate through the combined anterior approach for complex acetabular fracture treatment.

Methods: Patients with complex acetabular fractures treated at our trauma centre between January 2015 and December 2016 were retrospectively reviewed. Fractures were stabilized with an ilioischial plate via a modified Stoppa approach combined with the 1st window of the ilioinguinal approach. Interval between injury and surgery, operative time and intraoperative blood loss were recorded. Fracture reduction was evaluated radiographically with the modified Matta's criteria at 3 days postoperatively. Postoperative hip function was assessed using the modified Merle d'Aubigne and Postel clinical grading system over at least 1 year postoperatively.

Results: Twenty patients were included with an average follow-up of 17 months (range, 13-28). The mean time interval between injury and surgery was 7.0 days (range, 3-13 days), operative time was 2.0 hours (range, 1.4-3.2 hours), and intraoperative blood loss was 320 mL (range, 220-450 mL). Fracture reduction was excellent in 15 cases (75%), good in 3 cases (15%), fair in 1 case (5%), and poor in 1 case (5%). Final hip function was excellent in 13 cases (68%), good in 3 cases (16%), fair in 2 cases (11%), and poor in 1 case (5%). Bony healing was achieved in all cases and few complications were reported including recoverable obturator nerve injuries in 2 patients (10%) and traumatic arthritis in 1 patient (5%).

Conclusions: Anterior fixation of complex acetabular fractures with an ilioischial plate via the combined anterior approach yielded clinically satisfactory mid-term outcomes, providing a potentially effective alternative to the conventional treatment algorithm.
ADİ KONKORDATODA ALACAKLILARIN ALACAKLARINI BİLDİRMESİ
Authors: BÖRÜ Levent
Published: June 2019

Adi konkordato, iflasa tabi olup
olmadığına bakılmaksızın, borçlarını vadesi geldiği halde ödeyemeyen veya
vadesinde ödeyememe tehlikesi altında bulunan herhangi bir borçlunun borçlarını
proje ile belirli bir vade veya indirim yoluyla yeniden yapılandırabilecekleri
bir hukuki imkandır. Konkordato geçici mühleti sonunda konkordatonun başarıya
ulaşma ihtimalinin olması durumunda borçluya bir yıllık kesin mühlet verilir ve
ilan edilir. Bundan sonra İİK m. 299’a göre konkordato komiseri tarafından
yapılacak ilanla onbeş gün içinde alacaklıların alacaklarını bildirmesi
istenir. Alacaklıları alacaklarını bildirmeye davet ilan yoluyla olur; bununla
birlikte adresi belli olan alacaklılara ilanın birer örneği de posta yoluyla
bilgilendirme amacıyla yollanır. İlandan itibaren süresinde alacaklarını
bildirmeyen alacaklılar, borçlunun bilançosunda veya projede belirtilen
alacaklılar listesinde ayrıca kayıtlı olmadıkça, konkordato projesinin
müzakerelerine katılamayacaklardır. Başka bir deyişle alacaklıların, konkordato
projesinin oylamasının yapıldığı alacaklılar toplantısında oy kullanabilmeleri
ve nisaba dahil olabilmeleri için, alacaklarını bildirmeleri gerekmektedir.
İlanın yapılması ve alacaklıların alacaklarını bildirmesi konkordato projesinin
şekillenmesinde önemli bir rol oynamaktadır; zira alacaklılar toplantısı için
karar yeter sayısının sağlanabilmesi, borçlunun malvarlığı ile sorumlu olduğu
pasif kapsamının belirlenebilmesi ve akabinde konkordato projesinin tasdik
edilebilmesi için mutlak surette alacaklıların desteğinin sağlanabilmesi
gerekir. Bu noktada ilanın yapılması ile birlikte alacaklıların alacaklarının
niteliğine bağlı olarak alacaklarını süresi içerisinde bildirmelerinin veya
bildirmemelerinin hüküm ve sonuçları da farklı olabilecektir.
Clinical efficacy and safety of alemtuzumab in postmarketing practice
Authors: Khachanova N. V.
Published: June 2019

Clinical trials confirm alemtuzumab efficacy for multiple sclerosis treatment in terms of both conventional measures and combined criteria such as NEDA (no evidence of disease activity). However, established drug efficacy and convenient dosing schedule are balanced by the risk of serious adverse events. Therefore, it is necessary to inform physicians about the benefits of alemtuzumab therapy along with the pattern of its safety profile.The present review provides the analysis of alemtuzumab real-world studies in Europe, USA and other parts of the world. The information obtained can help physicians to prescribe and administer the drug properly and to perform effective safety monitoring for early detection of adverse events and saving the maximum treatment benefit for the patient.
Using kinetic isotope effect to evaluate the significance of the sequential and parallel steps: formation of microbial consortium during reversible anaerobic methane oxidation coupled with sulfate reduction
Authors: Vavilin Vasily , Lokshina Lyudmila , Rytov Sergey
Published: June 2019

The purpose of this study was to describe the dynamics of anaerobic oxidation of methane (AOM) coupled with sulfate reduction (SR) using experimental data from a continuous incubation experiments published earlier in order to show that formation of consortia of anaerobic archaea (ANME) and Desulfosarcina-like bacteria (DSS) may have a significant effect on sulfur isotope fractionation. The dynamic simulation of reversible AOM by ANME coupled with SR by DSS was performed. This simulation took into account biomass growth and fractionation of stable isotopes of sulfur. Two kinetic schemes with and without ANME + DSS consortium formation were tested. The respective models were applied at five influent methane concentrations. A good fit to experimental data was obtained only when assuming active ANME and DSS biomass accumulation. The assumption about incorporation of reversibility of anaerobic methane oxidation and sulfate reduction did not improve the model's fit to experimental data. In accordance with both the models, sulfur isotope fractionation was smallest for the highest influent methane concentration. The model considering the formation of consortia of ANME + DSS is proved to be more appropriate.
Management of wastewater in rural districts of Istanbul metropolitan municipality
Authors: Ekrem Karpuzcu M. , İnci Ali , Goktas Mihriban H. , Ozturk Izzet
Published: June 2019

Decentralized systems play a big role in wastewater treatment in rural areas. The aims of this study are to address the wastewater treatment and disposal problems for rural districts of Istanbul, to discuss the efficiencies of currently operated systems and to offer new appropriate wastewater treatment systems for small communities having a population up to 5,000. The management and final disposal alternatives for sludge generated in septic tanks are also discussed within the scope of this study. A sequencing batch reactor (SBR) system serving 2,500 people and a hybrid constructed wetland system serving 500 people are presented as case studies. A thorough evaluation based on the capacity and performance of the existing wastewater treatment systems in rural districts revealed that a number of these systems are not operating at their optimum. Improperly constructed sewer lines receive a lot of infiltration and inflow (I & I) after rainfall events, decreasing treatment performance and causing operational difficulties. Natural treatment systems such as constructed wetlands prove a viable alternative in these communities, especially for villages with populations less than 500 people.
Summary Prosedures and Optimization of Commercial Court Proceedings in Russia
Authors: Nikitin S. , Patsatsiya M.
Published: June 2019

This article deals with the problems involved in implementing simplified forms of legal proceedings in the Russian civil process, which is one of the important directions for optimizing commercial court proceedings. The study is largely based on the analysis of previously unpublished statistical information on the commercial courts of three districts for the period of 2016–2018, showing the results of their procedural activities in the framework of the procedures of simplified and writ proceedings in the context of court data of the commercial court system as a whole. The obtained results are highlighted taking into account domestic, foreign and international experience, doctrinal approaches and the existing need for the optimization of commercial court proceedings. The authors substantiate the conclusion that the consideration of cases in the procedures of simplified production facilitates significantly reducing the caseload burden on the commercial courts of first instance, both by simplifying the procedures for the consideration of these cases and by drawing up judicial acts on them. The article formulates proposals for the development of the current commercial procedural law, in particular the proposal to unify the procedural order of commercial court cases on the recovery of compulsory payments and sanctions. It further proposes possible variants of such unification.
Legal Techniques and Technology as the Most Important Factors for the Sustainable Development of the Societal Legal System
Authors: Malko A. , Kostenko M.
Published: June 2019

Legal techniques were initially developed as a kind of repeater of the legislatorʼs will into the language of law with the help of special skill in legal design. Historically, the theory of legal technique was formed in stages with state reforms, social transformations and active work on systematizing legislation having significant impact on it. At the present stage, legal technique resources are legislated in some CIS and European countries, and the status of legal technique is firmly entrenched in legal theory and practice in continental law countries as well as common law. Complications from modern legal life in society and the need to optimize legal activity drive the search for new ways to improve the legal technology field. The uniqueness of legal technology is that it links all types of legal activity into a single production process, standardizes its potentially separate segments and introduces sound stability into legal processes. This makes it possible to improve effectiveness indicators for consolidating legislative priorities and implementing them in practice, in order to ensure the national interests of the state. Combining the potential of legal technology and legal technique provides legal activity a systematic and constructive validity for legal transformations, hinders the expansion of legal errors, optimizes the stages of legislative activity, systematizes the actions and operations that are being implemented, and ultimately ensures high indicators for legal development and the achievement of the stateʼs constructive tasks.
Statistical Methods and Software for Substance Use and Dependence Genetic Research
Authors: Lan Tongtong , Yang Bo , Zhang Xuefen , Wang Tong , Lu Qing
Published: June 2019

Background:

Substantial substance use disorders and related health conditions emerged during the mid-20th century and continue to represent a remarkable 21st century global burden of disease. This burden is largely driven by the substance-dependence process, which is a complex process and is influenced by both genetic and environmental factors. During the past few decades, a great deal of progress has been made in identifying genetic variants associated with Substance Use and Dependence (SUD) through linkage, candidate gene association, genome-wide association and sequencing studies.

Methods:

Various statistical methods and software have been employed in different types of SUD genetic studies, facilitating the identification of new SUD-related variants.

Conclusion:

In this article, we review statistical methods and software that are currently available for SUD genetic studies, and discuss their strengths and limitations.
Cocaine-induced Changes in the Expression of NMDA Receptor Subunits
Authors: Smaga Irena , Sanak Marek , Filip Małgorzata
Published: June 2019

:

Cocaine use disorder is manifested by repeated cycles of drug seeking and drug taking.
Cocaine exposure causes synaptic transmission in the brain to exhibit persistent changes, which are
poorly understood, while the pharmacotherapy of this disease has not been determined. Multiple
potential mechanisms have been indicated to be involved in the etiology of cocaine use disorder.
The glutamatergic system, especially N-methyl-D-aspartate (NMDA) receptors, may play a role in
several physiological processes (synaptic plasticity, learning and memory) and in the pathogenesis
of cocaine use disorder. The composition of the NMDA receptor subunits changes after contingent
and noncontingent cocaine administration and after drug abstinence in a region-specific and timedependent
manner, as well as depending on the different protocols used for cocaine administration.
Changes in the expression of NMDA receptor subunits may underlie the transition from cocaine
abuse to dependence, as well as the transition from cocaine dependence to cocaine withdrawal. In
this paper, we summarize the current knowledge regarding neuroadaptations within NMDA receptor
subunits and scaffolding proteins observed following voluntary and passive cocaine intake, as
well as the effects of NMDA receptor antagonists on cocaine-induced behavioral changes during
cocaine seeking and relapse.