bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos
Published: June 2023

Abstract
Molecular modifiers of KRASG12C inhibitor (KRASG12Ci) efficacy in advanced KRASG12C-mutant NSCLC are poorly defined. In a large unbiased clinicogenomic analysis of 424 patients with non–small cell lung cancer (NSCLC), we identified and validated coalterations in KEAP1, SMARCA4, and CDKN2A as major independent determinants of inferior clinical outcomes with KRASG12Ci monotherapy. Collectively, comutations in these three tumor suppressor genes segregated patients into distinct prognostic subgroups and captured ∼50% of those with early disease progression (progression-free survival ≤3 months) with KRASG12Ci. Pathway-level integration of less prevalent coalterations in functionally related genes nominated PI3K/AKT/MTOR pathway and additional baseline RAS gene alterations, including amplifications, as candidate drivers of inferior outcomes with KRASG12Ci, and revealed a possible association between defective DNA damage response/repair and improved KRASG12Ci efficacy. Our findings propose a framework for patient stratification and clinical outcome prediction in KRASG12C-mutant NSCLC that can inform rational selection and appropriate tailoring of emerging combination therapies.
Significance:
In this work, we identify co-occurring genomic alterations in KEAP1, SMARCA4, and CDKN2A as independent determinants of poor clinical outcomes with KRASG12Ci monotherapy in advanced NSCLC, and we propose a framework for patient stratification and treatment personalization based on the comutational status of individual tumors.
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential
Authors: Sans Marta , Makino Yuki , Min Jimin , Rajapakshe Kimal I. , Yip-Schneider Michele , Schmidt C. Max , Hurd Mark W. , Burks Jared K. , Gomez Javier A. , Thege Fredrik I. , Fahrmann Johannes F. , Wolff Robert A. , Kim Michael P. , Guerrero Paola A. , Maitra Anirban
Published: June 2023

Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs harbors a gastric foveolar-type epithelium, and these low-grade mucinous neoplasms are harbingers of IPMNs with high-grade dysplasia and cancer. The molecular underpinning of gastric differentiation in IPMNs is unknown, although identifying drivers of this indolent phenotype might enable opportunities for intercepting progression to high-grade IPMN and cancer. We conducted spatial transcriptomics on a cohort of IPMNs, followed by orthogonal and cross-species validation studies, which established the transcription factor NKX6-2 as a key determinant of gastric cell identity in low-grade IPMNs. Loss of NKX6-2 expression is a consistent feature of IPMN progression, while reexpression of Nkx6-2 in murine IPMN lines recapitulates the aforementioned gastric transcriptional program and glandular morphology. Our study identifies NKX6-2 as a previously unknown transcription factor driving indolent gastric differentiation in IPMN pathogenesis.

Significance:

Identification of the molecular features driving IPMN development and differentiation is critical to prevent cancer progression and enhance risk stratification. We used spatial profiling to characterize the epithelium and microenvironment of IPMN, which revealed a previously unknown link between NKX6-2 and gastric differentiation, the latter associated with indolent biological potential.

See related commentary by Ben-Shmuel and Scherz-Shouval, p. 1768.

This article is highlighted in the In This Issue feature, p. 1749
Effect of the Directive and Non-directive Inspection Approaches on Teach-er Instructional Effectiveness in Government- aided Primary Schools in Nakisunga County, Uganda
Authors: Ntege Joseph Lubwama , Kasule Geirge Wilson , Owino Phillip , Mugizi Wilson
Published: June 2023

This study investigated the effect of the directive and non-directive school inspection approaches on teacher instructional effectiveness. While teacher instructional effectiveness was studied in terms of reporting on pupil academic achievements, teacher attitudes, effective planning, attendance and pedagogical approaches, the directive School inspection approach was studied in terms of directing and evaluation of teacher knowledge yet the non-directive approach was studied in terms of team planning and consultations. A cross-sectional survey mixed research design using the quantitative and qualitative approaches on a sample of 178 people namely teachers, head teachers, school inspectors and education officers was adopted. While quantitative data was collected using survey questionnaires and analysed using inferential analysis, qualitative data was collected through interviews, focus group discussions and analysed by grouping the responses in themes which were merged with quantitative findings. The findings showed that all the attributes of directive inspection approach were positively insignificant to teacher instructional effectiveness explaining that they had no impact on teacher instructional effectiveness. Similarly, team planning had a positive and insignificant relationship meaning that it had no effect on teacher instructional effectiveness.  In conclusion, only team planning had effect on teacher instructional effectiveness and consultation did not have any effect. It was recommended that school inspectors should use the non-directive inspection approach because of sub-variable team planning that had a positive effect on teacher instructional effectiveness.
Effect of the Collaborative School Inspection Approach on Teacher Instruc-tional Effectiveness in Government-aided Primary Schools of Nakisunga County, Mukono District, Uganda
Authors: Ntege Joseph Lubwama , Wilson Kasule George , Mugizi Wilson , Phillip Owino
Published: June 2023

The study investigated the effect of the collaborative school inspection approach on teacher instructional effectiveness in government-aided primary schools in Nakisunga County, Mukono district, Uganda. Teacher instructional effectiveness was studied in terms of reporting on pupil academic achievements, teacher attitudes, effective planning, attendance and pedagogical approaches. Collaborative school inspection approaches were studied in terms of support supervision, feedback, trust and respect. The study adopted a cross-sectional survey mixed research design which used both quantitative and qualitative approaches on a sample of 178 people that included teachers, head teachers, school inspectors and education officers, all from Nakisunga County, Mukono district. While Quantitative data was collected using self-administered survey questionnaires, qualitative data was collected using interviews and focus group discussions. Data collected quantitatively was analysed using inferential analysis yet qualitative data was analysed by grouping the responses from the head teachers, school inspectors and education officers in themes which were merged with quantitative findings. The findings showed that all the sub-variables of the collaborative school inspection approach were positively significant to teacher instructional effectiveness. It was concluded that the collaborative school inspection approach has impact, on teacher instructional effectiveness. Therefore, it was recommended that because the collaborative school inspection approach has impact on teacher instructional effectiveness it should be used in government-aided primary school inspection activities always and vigilantly because all its sub-variables were positively significant to teacher instructional effectiveness.
A Personal Narrative Experience of Teachers Teaching Purposive Commu-nication During the New Normal Education
Authors: Salendab Fahad Abdul , Akmad Saiden Panggo
Published: June 2023

This study explored the teachers’ teaching experiences in purposive communication during the new normal education setup at Sultan Kudarat State University-Kalamansig Campus. Qualitative research design using the narrative research methods was the research design of this study. It used non-probability purposive sampling as the sampling technique. There were five (5) teachers handling purposive communication. Moreover, this study employed a semi-structured interview guide with open-ended questions. The data were analyzed using Colizzi’s thematic analysis.

The teachers' experiences teaching purposive communication seem fruitful and efficient for students learning. Classes were conducted using the blended learning approach. Due to internet connectivity issues, Asynchronous was the typical learning mode than synchronous session. Further, the learning assessment was found to be unauthentic because it was conducted using asynchronous mode. Internet connectivity and power interruptions were the greatest challenges ever experienced by the teachers. Their coping mechanism included psychological health and well-being and proactive and approach-oriented application. The use of a personal budget is also included.

It is concluded that teachers have issues in lesson planning, classroom management, internet connectivity, and managing students' virtual behavior in the new normal environment. Teachers have utilized a variety of strategies to overcome difficulties.

It is recommended that the institution should provide planning programs as a foundation for new normal teaching and perform a series of studies on instructors' experiences in the new normal educational scheme. The faculty should evaluate the practicability of their teaching methods to satisfy the needs of students with diverse cultures during the new normal.
Why Crowdfund? Motivations of Philippine-Based Project Owners and Backers
Authors: Vergara Raymond Allan G. , Vergara Kimberly Christie S.
Published: June 2023

This study examines why project owners and campaign backers participate in crowdfunding. It explores what motivates crowdfunding participants to seek funding or fund projects using a multiple-case study approach. This study finds that project owners are motivated to crowdfund because of financial and marketing benefits. On the other hand, campaign backers are motivated to fund campaigns because they want early access to products, participate in the community, and support the project for altruistic motives.
Classification of Soil Distribution on the Island of Saparua Based on the Soil Classification System National and the Equivalent to Soil Taxonomy
Authors: Risamasu Robby. G.
Published: June 2023

This research aims to classify the distribution of soils on Saparua Island, Central Maluku Regency, based on the Subardja, D, et al, (2016) and soil taxonomy (SSS, 2022). The benefit of this research is to find out the distribution of soils on Saparua Island to support the regional development plan. The method used is the survey method, with a semi-detailed survey level of a 1:50,000 scale. The pattern of the approach used is a physiographic analysis approach to landscapes, in which the research area is divided into terrestrial units based on the similarity of the properties of the variables that influence soil formation. The base map used in this study is a land unit map with a scale of 1:50,000. The results showed that the factors and processes involved in soil formation in the study area were parent material and topography, leaching, and eluviation processes. The soils found consisted of seven types of soil with 11 subgroups, namely: Regosol Eutric (Typic Udipsamments and Lithic Udipsamments), Litosol (Lithic Udorthents), Kambisol Distrik (Typic Dystrudepts), Kambisol Litik (Lithic Eutrudepts), Gleisol Eutrik (Typic Endoaquents and Aquic Eutrudepts), Gleisol Distrik (Typic Haplaquepts), Podsolik Kandik (Typic Hapludults and Typic Kandik), and Organosol Hemik (Hydric Tropohemists) were also found.
Hubungan Kualitas Tidur Terhadap Kejadian Miopia Pada Anak
Authors: Setyaningayu Prima Fermalina , Sidharta Bragastio , Candrawati Pertiwi Febriana , Indrawanto Iwan Sis
Published: June 2023

Latar Belakang: Miopia (rabun jauh) adalah gangguan penglihatan refraksi yang paling umum pada anak-anak. Hal ini ditandai dengan kaburnya objek yang dilihat dari kejauhan, dan umumnya merupakan akibat dari pemanjangan bola mata yang tidak normal ? yang menyebabkan bayangan bias yang dibentuk oleh kornea dan lensa jatuh di depan fotoreseptor retina. Faktor yang menyebabkan terjadinya miopia belum diketahui dengan pasti, namun ada beberapa faktor yang mendukung terjadinya miopia yaitu faktor genetik, jenis kelamin, aktivitas fisik dan tidur. Kualitas tidur dikaitkan dengan terjadinya miopia. Kualitas tidur yang berpengaruh menjadi faktor terjadinya miopia adalah dilihat dari durasi tidur, jadwal tidur, dan gangguan tidur. Tujuan: Mengetahui hubungan kualitas tidur terhadap kejadian miopia pada anak Metode Penelitian: Jenis dari kajian pustaka ini adalah narrative review dengan menerapkan PICO (population, intervention,comparison dan outcome). Literatur yang dimasukkan ke dalam penelitian ini akan diperoleh dari database jurnal yang terdiri dari Pubmed, Cochrane, Google Scholar. Hasil: Hasil penelitian dari jurnal yang didapatkan, menunjukkan kualitas tidur berpengaruh terhadap kejadian miopia, terutama pada kondisi dengan miopia yang tinggi. Kualitas tidur yang buruk meningkatkan prevalensi terjadinya miopia. Anak dengan miopia memiliki durasi tidur yang lebih pendek dibandingkan dengan anak tidak miopia. Kesimpulan: Kualitas tidur berpengaruh terhadap terjadinya miopia pada anak, khususnya pada miopia tinggi. Durasi dan latensi tidur termasuk dalam penilaian dari kualitas tidur dan keduanya juga berpengaruh terhadap kejadian miopia pada anak.
Gambaran Karakteristik Dan Tajam Penglihatan Pada Pasien Diabetic Macular Edema (DME) Yang Mendapat Injeksi Bevacizumab Di Klinik Spesialis Mata SMEC Siantar Tahun 2021
Authors: Fikri Handy Khairul , Bangun Christina Yosephine Yudiathy
Published: June 2023

Pendahuluan: Retinopati diabetik adalah komplikasi diabetes yang paling umum. Diabetic Macula Edema (DME) adalah komplikasi independen dari retinopati diabetik dan terjadi pada sekitar 6,8% pasien DM. Salah satu patogenesis pada DME adalah karena peningkatan ekspresi VEGF. Selama beberapa tahun terakhir,anti Vaskular Endothelial Growth Factor (anti-VEGF) telah menjadi terapi lini pertama. Bevacizumab adalah anti-VEGF yang dapat meningkatkan Best Corrected Visual Acuity (BCVA) dan mengurangi Central Macular Thickness (CMT) pada pasien DME. Tujuan: mengetahui gambaran karakteristik pasien DME yang mendapat terapi injeksi intravitreal serta apakah terdapat perbaikan tajam penglihatan pasca operasi pada pasien (DME) yang mendapat terapi injeksi intravitreal di Klinik Spesialis Mata SMEC Siantar tahun 2021. Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan studi cross sectional secara retrospektif dengan mencatat data pasien DME yang mendapat injeksi bevacizumab intravitreal pada 1 Januari 2021 sampai 31 Desember 2021 yaitu sebanyak 20 sampel yang sudah disaring termasuk kriteria inklusi dan eksklusi, serta dilakukan uji normalitas Shapiro-wilk dan uji analisis menggunakanpaired T-test. Hasil:Jenis Kelamin laki-laki mempunyai jumlah yang lebih banyak (52.1%) daripada perempuan (47.9%). Rerata umur pasien yang mendapat injeksi bevacizumab intravitreal 62.12?9.22.Tajam penglihatan pasien mengalami perbaikan pada semua kelompok rawatan yaitu yang mendapat injeksi 1x,2x dan 3xselama rawatan Simpulan: terdapat perbaikan tajam penglihatan pada pasien yang menjalani injeksi bevacizumab intravitreal
High degree of independence in the feeding apparatus of planarian flatworms
Authors: Wu Ming-Qi , Liu Hai-Long , Xia Meng-Yu , Zhang Yu , Sluys Ronald , Wang An-Tai
Published: June 2023

In this contribution, feeding behaviour assays with the three species Paucumara falcata, Dugesia sp. and Girardia sp. were used to investigate the function of the pharynx during feeding and whether absence of feeding behaviour until full regeneration is a widespread phenomenon among planarians from different taxonomic groups. Our results showed that feeding behaviour of decapitated flatworms was inhibited. Intact worms responded only to pork liver pieces, but isolated pharynges were highly responsive to both pork liver pieces and pork liver extracts. After transverse cutting, the oral part of the isolated pharynx was responsive, while the aboral part showed no response to food items, suggesting that the oral portion of pharynx plays a crucial role during feeding.
Hugo Grotius’s De iure belli ac pacis: Henricus Laurentius’ Re-Issue (1647) of the 1631 Edition
Authors: Cleary Matthew , Corredera Edward Jones , Dufour Pablo Nicolas , Nathan Jonathan , Salerno Emanuele , Somos Mark
Published: June 2023

This research note is the eighth instalment in our series of preliminary findings on the census and study of the reception of De iure belli ac pacis. The note presents a bibliographical description of Laurentius’ 1647 re-issue of the 1631 edition by Blaeu, considers Laurentius’ motivation and methods of production, lists and maps the currently known twenty-three surviving copies, and briefly describes two notable exemplars.
Solving nomenclatural problems of genus-group names of the cuckoo-wasps (Hymenoptera, Chrysididae): objectively invalid and unavailable names, new type-species designations, new names, a new genus and new synonymies
Authors: ROSA PAOLO , PAVESI MAURIZIO , BROTHERS DENIS J.
Published: June 2023

Information is provided for 143 objectively invalid or unavailable genus-group names used in Chrysididae; 34 are objectively invalid, of which 18 are junior homonyms (five of these are also currently junior subjective synonyms), 18 are junior objective synonyms (two of these are also junior homonyms) of which seven are unjustified emendations, and two are unnecessary replacement names. The remaining 109 names are unavailable; 96 are incorrect subsequent spellings, most of them were originally lapsus calami or misprints, one is hereby deemed to be an incorrect original spelling, eight are nomina nuda, three were originally published as junior synonyms and never adopted before 1961 as valid names of any taxa, and one is a vernacular name previously considered as valid. Gender, type species, taxonomic history and status are given for each name except for incorrect subsequent spellings and unjustified emendations. Some cases of homonymies with taxa currently classified as non-animal are discussed. For two such junior homonyms, denoting genus-group taxa considered as valid in the present work, new replacement names are proposed: Linsenmaierella Rosa & Pavesi nom. nov. for Chrysidella Linsenmaier, nec Pascher; and Rhipidochrysis Rosa & Pavesi nom. nov. for Pleurochrysis Bohart, nec Pringsheim. New generic synonymies are established: consequent on new type-species designations, Leptoglossa Klug becomes a junior objective synonym of Parnopes Latreille syn. nov., and Pyrochloris Klug becomes a junior objective synonym of Euchroeus Latreille syn. nov.; Pseudodichrysis Trautmann is a junior objective synonym of Dichrysis Lichtenstein syn. nov. and the latter is in turn a junior subjective synonym of Chrysis Linnaeus. Platycelia Dahlbom is selected by the authors, acting as First Revisers, as the correct original spelling, and the simultaneously published Platycoelia is therefore deemed to be an incorrect subsequent spelling. The validation of Philoctetes Abeille de Perrin, not available when originally proposed, is discussed. Morphochrysis Rosa & Pavesi gen. nov. (type species: Chrysis pulchella Spinola) is here described; it includes members of the Chrysis pulchella species group previously included in Gonodontochrysis Semenov-Tian-Shanskij & Nikol’skaya, an unavailable name. The Chrysis zaravshanica species group is merged with the pulchella species group. A new specific synonymy within this group is proposed: Chrysis zaravshanica Tarbinsky syn. nov. of C. personata Semenov-Tian-Shanskij.
Taxonomic updates for diurnal velvet ants (Hymenoptera: Mutillidae) in the United States of America
Authors: WILLIAMS KEVIN A.
Published: June 2023

This paper provides miscellaneous taxonomic updates for diurnal velvet ants in the USA. Six valid species of Dasymutilla Ashmead, 1899, one valid species of Ephuta Say, 1836 and six valid species of Pseudomethoca Ashmead, 1896 are regarded. Two new species are described: Pseudomethoca peremptrix sp. nov. and P. sonorae sp. nov. The female formerly associated with Dasymutilla zelaya (Blake, 1871) is recognized as a color variant of D. vestita (Lepeletier, 1845). Sixteen new synonymies are proposed: Dasymutilla chisos Mickel, 1928, syn. nov. under D. gloriosa (Saussure, 1868); D. cotulla Mickel, 1928, syn. nov., D. homole Mickel, 1928, syn. nov. and D. vandala Mickel, 1928, syn. nov. under D. vestita (Lepeletier, 1845); D. dorippa Mickel, 1928, syn. nov. under D. flammifera Mickel, 1928; D. ocydrome Mickel, 1928, syn. nov. under D. connectens (Cameron, 1895); Mutilla phaon Fox, 1899, syn. nov. under D. pseudopappus (Cockerell, 1895); M. zelaya Blake, 1871, syn. nov. under D. gorgon (Blake, 1871); Ephuta tentativa Schuster, 1951, syn. nov. under E. scrupea Say, 1836; P. dentifrontalis Bradley in Mickel, 1924, syn. nov. under P. athamas (Fox, 1899); P. albicoma Mickel, 1924, syn. nov., P. contumeliosa Mickel, 1935, syn. nov., P. manca Mickel, 1924, syn. nov. and P. oculissima Mickel, 1924, syn. nov. under P. contumax (Cresson, 1865); M. aeetis Fox, 1899, syn. nov. under P. sanbornii (Blake, 1871); and P. (Nomiaephagus) vanduzei Bradley, 1916, syn. nov. under P. wickhami (Cockerell & Casad, 1895).
Settling accounts: Indigenous bankers in search of new histories in the twentieth century
Authors: Subramanian Lakshmi
Published: June 2023

This article focuses on the making of the discourse on indigenous banking in colonial India, which was linked to the transformation of the Indian economy and involved the repositioning of indigenous banking and the brokerage business. The rationale underlying indigenous histories of capital and custom was based on the ideas of public good and trust, which could bridge the gap between regulation and law on the one hand and informal practices and custom on the other. This article examines a range of writings and histories composed in both English and vernacular languages by the colonial state and its subjects in the nineteenth and twentieth centuries, which were concerned with defining and delegitimising or supporting indigenous banking, to revisit the conceptualisation of commerce and banking as a public good and subsequently retell the story of indigenous banking in colonial India.
Re-Conceptualizing Kaepernick’s Kneeling Protests and His Banishment From the NFL as an Infringement on His “Right to Work”
Authors: Smith Earl , Hattery Angela J. , Kiss Marissa , Foltz Katelyn E.
Published: June 2023

A nascent literature is emerging that analyzes the case of Kaepernick who was “locked out” of the National Football League (NFL) beginning in 2017 because he chose to protest police brutality, systemic racism, and white supremacy. Using status expectations states theory and prototypicality theory, our research re-conceptualizes Kaepernick’s lock-out as an infringement on his right to work. First, we utilize a modified case-study approach comparing his experiences to those of six other Black male athletes who were “locked out.” Second, we utilize data and “matched cases” to demonstrate empirically that Kaepernick was locked out of the league while quarterbacks who were less qualified (based on specific performance measures) were allowed to continue working. Our analysis demonstrates that Kaepernick was denied his “right to work” because he, like other Black male athletes before him, challenged structural racism and white supremacy.
From Heroism Motivation to Civic Engagement: The Role of Self-Construals
Authors: Sun Yuning , Igou Eric R. , Kinsella Elaine L.
Published: June 2023

Heroism is an expression of self-actualization and a pinnacle social state that is of fundamental interest to humanistic psychology. Heroes help individuals understand the values and norms within society and prompt individuals to do what they can for those who need help. We examine the relationship between the motivation to act heroically and civic engagement and explore how self-construals offer insights into this relationship. In two studies, we found that heroism motivation was a significant and consistent predictor of civic engagement. Furthermore, we found that the association between heroism motivation and civic engagement was explained by self-construals. More specifically, we found that heroism motivation was indirectly related to civic engagement when people adopted an interdependent self-construal (but not an independent self-construal). The findings from the present research contribute to our understanding of how the motivation to behave heroically affects civic engagement and demonstrate the importance of self-construals for the link between these types of motivation and behavior.
The applicability of Anglosphere-based popular music learning culture characterisations to a Malaysian context
Authors: Choong Hueyuen
Published: June 2023

This article explores the ways in which popular musicians in Malaysia learn the craft of Western popular music-making in comparison to those in the United Kingdom. Literature that studied popular musicians and their practices had largely focused on communities within Anglosphere regions, and there are insufficient understandings of the journeys of non-Anglosphere popular musicians to determine if their experiences coincided with those from Anglosphere nations. In this mixed method study, popular musicians from Malaysia and the UK completed online questionnaires that enquired into their experiences with formal learning, as well as the practices they engaged in. Secondary data was also harvested from literature based on UK musicians for triangulation purposes. Though the findings indicated numerous overlaps in the experiences of popular musicians from both countries, there were areas of distinction. Malaysian popular musicians were more inclined than their counterparts in the UK, to engage with formal popular music learning, to cultivate a reliance on notation, and to experience instrumental lessons that comprised more features of informal learning. Implications from this article include the need to further investigate the factors behind the disparities, and to afford increased attention towards the learning cultures of non-Anglosphere popular musicians.
Co-producing ideas, leaders and learning – teaching participatory activism in Stoke-on-Trent
Authors: Goldstraw Katy
Published: June 2023

This paper will critically analyse a University-funded Centre of Learning and Pedagogic Practice (SCoLPP) project. The project was designed to integrate the co-produced learning from the Action on Poverty and Hardship Degree steering group, which was made up of local and national Voluntary and Community Sector (VCS) leaders and low-income students on the course. The project was directly aligned with the University Academic Strategy, designed to integrate academic integrity into innovative curriculum design. This article will critically discuss how the project, in its co-produced place-based approach, aligned its curriculum design to external engagement within Stoke-on-Trent. The Action on Poverty and Hardship Degree team worked over the course of 18 months with a steering group of local and national voluntary sector employers to actively recruit and support students from low-income backgrounds to become engaged in anti-poverty activism. This article will critically discuss how the voices of students with lived experience of poverty engaged to co-produce learning with local and national voluntary sector leaders. The paper will critically reflect on best practice in co-produced curriculum development.
Study on the Performance of laser-assisted fast tool servo machining device for glass-ceramic
Authors: Fan Mingxu , Zhou Xiaoqin , Chen Shunfa , Jiang Shan , Song Jinzhou
Published: June 2023

As an optical hard brittle material, glass-ceramic is widely used in radome, astronomical telescopes, and laser industries. However, an efficient method for machining optical free-form surface of glass-ceramic still needs to be studied by academia and industry. In this study, a laser-assisted fast tool servo machining device for glass-ceramic is developed. The theoretical stiffness of semicircular flexure hinge in the device is calculated by flexibility matrix method. The displacement output characteristics of the device are verified by simulation and displacement measurement experiment. Static and dynamic temperature measurement experiments of glass-ceramic are carried out respectively. The free-form surface morphology of glass-ceramic is obtained through machining experiment. Laser-assisted fast tool servo machining can reduce surface roughness by 24.4% and tool wear by 35.7% compared to conventional machining, which fully proves that the laser-assisted fast tool servo machining device can obtain higher machining quality of optical free-form surface.
A digital twin-driven dynamic path planning approach for multiple automatic guided vehicles based on deep reinforcement learning
Authors: Bao Qiangwei , Zheng Pai , Dai Sheng
Published: June 2023

With the increasing demand for customization, the tendency of mechanical manufacturing has gradually shifted to flexible and mixed-line production, which brings new challenges to the existing scheduling pattern. As an indispensable part, logistics is responsible for establishing connections among various production equipment and processes. Meanwhile, the promotion of digital twin theory introduces an application schema for the logistics system. However, there is still a deficiency in the real-time dispatching and path planning of logistics equipment due to the uncontrollability of algorithm efficiency for complex scenes. To fill this gap, a digital twin-driven dynamic path planning approach for multiple automatic guided vehicles (AGVs) is proposed. Firstly, the AGVs are virtualized as the major component of logistics systems, while the ontology expression of logistics tasks is consistently accomplished as well. Secondly, the digital twin-driven application framework of multi-AGV dispatching is established. Moreover, a dynamic path planning method for AGVs relying on deep reinforcement learning is implemented. A segmented path planning method is illustrated considering potential route conflicts, which is regarded as the key contribution of the presented research. At last, a case study is illustrated to show the entire process of multiple vehicle path planning and conflict resolution.
Design optimization of composite fan blade in aircraft engine subjected to bird strike loading
Authors: Yella Gruhalakshmi , Jadhav Prakash
Published: June 2023

Bird strike has been a perennial problem for all airline companies in the world. It is the most important design criteria for the fan blades of an aircraft engine. As it is not possible to manufacture and test aircraft engines again and again for small design changes, through the simulation analysis, it is possible to study the ways to reduce the impact of the bird on a jet engine by using appropriate design and manufacturing methods for the blade. This research suggests using two fibers (hybrid) in place of the single fiber composite blade which is currently in use to reduce the delamination issues. In the first stage of this research, representative composite coupon models for combinations of hybrid fiber joint positions were created and linear static analysis was performed. For the validation of simulation methodology, a few coupons were manufactured and tested in the laboratory. Further, dynamic bird strike analysis on sub-element level models was carried out in the second stage with various joint location combinations. Next, the plate-level representative blade model was designed with the original dimensions of the aircraft engine fan blade, and bird strike analysis was performed. The behavior of the representative plate with hybrid interface was studied, and the levels of inter-laminar shear strain were checked, by varying the joint location of the two composites. Some of the shortlisted cases do show significant promise of being damage tolerant under bird strike loading.
The Pontine Marshes: An integrated study of the origin, history, and future of a famous coastal wetland in Central Italy
Authors: Sevink Jan , de Haas Tymon CA , Alessandri Luca , Bakels Corrie C , Mario Francesco Di
Published: June 2023

The Pontine Marshes (Central Italy) are known for their long drainage history starting early in Roman times and culminating in their reclamation ( bonifica integrale) by the Fascist’s regime under Mussolini, mostly in the 1930s of past century. The geology of this coastal wetland and causes for its drainage problems received limited attention till recently. We reviewed results from recent studies, identified still existing knowledge gaps and performed additional research to fill these, to produce a full description of the Holocene history and drainage of these marshes. Massive coring data that served to map the soils and surficial geology, observations in archaeological excavations, analytical data on soil and sediment characteristics, and radiocarbon datings allowed us to distinguish several phases in this history, with a main break in the early Roman Republican period with the first systematic drainage works. Earlier, natural processes brought about by sea level rise largely controlled its drainage. Once artificial drainage started, soil subsidence became an important process, aggravating the drainage problems. The bonifica introduced mechanical drainage, temporarily masking the impacts of subsidence. We quantified the historical subsidence using DTMs and developed scenarios for the impacts of sea level rise and subsidence in 2100 and 2200, assuming that this rise will be mitigated by a coastal defence system and enhanced capacity of the mechanical drainage. Our results demonstrate the important role of soil subsidence throughout the history of this wetland and need to include subsidence in scenarios for the impacts of sea level rise.
Governing by entrepreneurship: Entrepreneurial ecosystems and socio-spatial difference
Authors: Hartman Julian B , Kear Mark T
Published: June 2023

Literature on entrepreneurial ecosystems (EEs) has grown rapidly over the past 5 years, using the concept as a framework to understand regional clusters of entrepreneurship. This article reviews, critiques, and extends the concept of the EE, arguing for its relevance in studying the political economy of urban space. To make this argument, we distinguish between niche EEs (NEEs) and growth EEs (GEEs). This distinction is based on the overlapping but distinct networks of actors and institutions forming each type of EE and also reflects broadly different relationships to growth and productivity, the entrepreneurial subject, global and local scales, and financial ecologies. We argue that EE research has largely focused on GEEs to the neglect of NEEs; by broadening the EE concept, we address shortcomings in the treatment of small businesses, financial relations, social difference, as well as urban politics within the EE literature. Drawing on the EE literature and interviews from a case study of Boston, we show that the infrastructure of GEEs and NEEs are not only “for” fast- and slow-growing businesses, respectively, but reinforce social and economic differences. While NEEs do redistribute resources to marginalized entrepreneurs, these resources are focused on building businesses and only indirectly related to the needs of marginalized communities and equitable development more generally.
Self-Talk: An Interdisciplinary Review and Transdisciplinary Model
Authors: Latinjak Alexander T. , Morin Alain , Brinthaupt Thomas M. , Hardy James , Hatzigeorgiadis Antonis , Kendall Philip C. , Neck Christopher , Oliver Emily J. , Puchalska-Wasyl Małgorzata M. , Tovares Alla V. , Winsler Adam
Published: June 2023

The present work synthesises the self-talk literature and constructs a transdisciplinary self-talk model to guide future research across all academic disciplines that engage with self-talk. A comprehensive research review was conducted, including 559 self-talk articles published between 1978 and 2020. These articles were divided into 6 research categories: (a) inner dialogue, (b) mixed spontaneous and goal-directed organic self-talk, (c) goal-directed self-talk, (d) spontaneous self-talk, (e) educational self-talk interventions, and (f) strategic self-talk interventions. Following this, critical details were extracted from a subsample of 100 articles to create an interdisciplinary synthesis of the self-talk literature. Based on the synthesis, a self-talk model was created that places spontaneous and goal-directed organic self-talk as well as educational and strategic self-talk interventions in relation to variables within their nomological network, including external factors (e.g. task difficulty), descriptive states and traits (e.g. emotions), behaviour and performance, metacognition, and psychological skills (e.g. concentration).
Fueling the Creative Spark: How Authentic Leadership and LMX Foster Employees’ Proactive Orientation and Creativity
Authors: Sumanth John J. , Černe Matej , Hannah Sean T. , Škerlavaj Miha
Published: June 2023

Creativity is a critical determinant of organizations’ abilities to compete and perform in rapidly changing and complex contexts. Though scholars have identified several contextual factors, such as leadership, that motivate employees’ creative performance, the psychological mechanisms and boundary conditions underpinning this relationship are relatively unknown. Drawing on social exchange theory, we propose that a proactive orientation, a psychological state rooted in the cognitive and behavioral process of setting a proactive goal and striving to achieve it, is a critical mechanism linking authentic leadership to employees’ creativity. Across two field studies of working professionals in Central Europe and the U.S., we show how authentic leadership fuels employees’ creative performance through a proactive orientation and introduce leader–member exchange (LMX) as an important moderator of this mediated relationship. In Study 1, using a sample of European manufacturing employees, we find support for the mediating role of a proactive orientation linking authentic leadership to creative performance, above, and beyond the effects of ethical leadership. In Study 2, using a sample of university staff, we replicate this finding and extend it by highlighting the moderating role of LMX on the authentic leadership-proactive orientation relationship.
A case report and a brief literature review of belly dancer’s dyskinesia in a pregnant patient
Authors: Tafesse Mengesha Abenet , Tilahun Maru Surafel , Ashrafi Mahabadi Mohammadjavad , Adugna Abebe Matyas , Moges Abera Berhanu , Derafsh Ehsan
Published: June 2023

Belly dancer’s dyskinesia is a rare movement disorder that can be classified under hyperkinetic movement disorders. It is characterized by rhythmic or semi-rhythmic contractions of the diaphragm and other abdominal muscles that are brief and involuntary that cannot be voluntarily suppressed but could be influenced by respiratory maneuvers. Belly dancer’s dyskinesia in pregnancy even rarer, there have only been five reported cases. Here, we reported 19-year-old Ethiopian pregnant women who presented with oscillating movements of the abdomen that occurred at her ninth month of pregnancy. The general medical and neurological examinations were unremarkable. Complete blood count, basic metabolic panels, and biochemistry tests were all within the normal range. The patient responded to the trial of valproate with complete resolution of the abdominal dyskinesia after delivery.
Clinical Outcomes of Indigenous Versus Non-Indigenous Patients: A Multicenter Retrospective Cohort Study in the Province of Quebec
Authors: Diendéré Ella , Turgeon Alexis F. , Gagnon-Labelle Katherine , Couture Amélie , Neveu Xavier , St-Onge Maude
Published: June 2023

Introduction:

Canadian Indigenous populations have a high incidence of poisoning; it has been suggested that care provided to the population living in remote areas is suboptimal. Our study aims to compare the continuum of care of poisoned people in Indigenous communities with those in non-Indigenous communities located in rural regions in the province of Québec.

Methods:

We conducted a multicenter retrospective cohort study using data from the Center Antipoison du Québec (CAPQ) over a 2-year period (2016-2017). We evaluated the care trajectory of Indigenous patients suffering of poisoning as compared to non-Indigenous patients living in rural areas. Our primary outcome was the duration of CAPQ involvement in case management. Our secondary outcome was the symptoms severity at the end of case management.

Results:

Among 491 identified poisoned patients (238 Indigenous/253 non-Indigenous), the duration of CAPQ involvement in case management was 9.4 h [2.9-21.3] for Indigenous patients versus 5.5 h [0.1-14.4] for non-Indigenous patients. No statistically significant difference was found between groups (geometric means ratio (GMR) adjusted = 1.08; [0.84; 1.38]). Results were consistent by age and sex groups. Most patients, in both Indigenous and non-Indigenous, showed mild to moderate symptoms at follow-up (59% vs 54%). One death was registered in each group. The CAPQ received a limited number of calls from the non-conventioned First Nations during the study period.

Conclusions:

We did not observe differences on the duration in case management. Perceptions of suboptimal care provided to rural Indigenous population are likely to be related to geographical remoteness rather than ethnicity. Further research is needed to better identify potential factors involved in the continuity of care provided in emergency situations. Another study will be carried out to describe the Indigenous realities and to better understand the results of this study.
Developing a Theory-Based Summative Testing Approach to Evaluate a Mobile Health App for Older Adults
Authors: Hale Timothy M. , Azevedo Renato F. L. , Sun Kang , Rogers Wendy A.
Published: June 2023

We describe a method of selecting and organizing tasks for summative testing of a new mobile health (mHealth) app by older adults. Summative evaluations of mobile health apps often focus on “ease of use” assessed by time to complete tasks and the number of use errors. This is not an optimal approach for older users who are more likely to have slower response times and be less experienced with these technologies. In testing with older users, it is important to incorporate the expected process of learning a new app without the use of training or extensive instructions. We drew on the theories of Mastery Learning, Cognitive Load, and Teach to Goal to inform our selection of tasks and the organization of task scenarios to better simulate the users’ patterns of exploration, learning, and initial use of a mobile app. This research has general relevance for human factors professionals involved in planning, conducting, and reporting the findings from summative evaluations for a broad range of mHealth apps and user groups.
Improving Prescribing through User-Centered Design: Design Guide and Interface Examples for Anticoagulant Medication Alerts
Authors: Jacob Seagull F. , Lanham Michael , Pomorski Michelle , Callahan Mollie , Barnes Geoffrey D.
Published: June 2023

Direct Oral Anticoagulants (DOACs) are beneficial blood-thinning medications that are frequently misprescribed. Clinical decision support systems can be effective in reducing these prescription errors through well-designed medication alerts. The effectiveness of alerts can be improved through a User Centered Design (UCD) process. We describe the multi-stage UCD process used to (1) produce initial draft alerts, (2) refine the designs, and (3) validate the designs and findings. The resulting prototype DOAC prescribing alert design is presented with annotations of design principles that were derived and applied. The principles of design for these DOAC medication alerts may be relevant more broadly to the design of other medication alerts.
Bakakinite, Ca2V2O7, a new mineral from fumarolic exhalations of the Tolbachik volcano, Kamchatka, Russia
Authors: Pekov Igor V. , Agakhanov Atali A. , Koshlyakova Natalia N. , Zubkova Natalia V. , Yapaskurt Vasiliy O. , Britvin Sergey N. , Vigasina Marina F. , Turchkova Anna G. , Nazarova Maria A.
Published: June 2023

The new mineral bakakinite, ideally Ca2V2O7, was found in the high-temperature (not lower than 500°C) exhalations of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with anhydrite, svabite, pliniusite, schäferite, berzeliite, diopside, hematite, powellite, baryte, fluorapatite, calciojohillerite, ludwigite, magnesioferrite, anorthite, titanite and esseneite. Bakakinite forms flattened crystals up to 30 × 5 μm, typically distorted. The mineral is transparent, colourless or pale yellow, with strong vitreous lustre. Electron microprobe analysis gave (wt.%): CaO 37.04, SrO 0.26, SiO2 0.16, P2O5 1.48, V2O5 49.47, As2O5 10.85, SO3 0.35, total 99.61. The empirical formula calculated on the basis of 7 O apfu is (Ca1.99Sr0.01)Σ2.00(V1.64As0.28P0.06Si0.01S0.01)Σ2.00O7. The Dcalc is 3.463 g cm–3. Bakakinite is triclinic, P$\bar{1}$, unit-cell parameters are: a = 6.64(2), b = 6.92(2), c = 7.01(2) Å, α = 86.59(7), β = 63.77(7), γ = 83.47(6)°, V = 287.0(5) Å3 and Z = 2. The strongest reflections of the powder X-ray diffraction pattern [d,Å(I)(hkl)] are: 4.647(27)(111, 0$\bar{1}$1), 3.138(76)(002), 3.103(100)(120, 121), 3.027(20)(021), 2.960(81)(200), 2.158(19)(031, 302), 1.791(16)(320), 1.682(16)(114) and 1.584(17)(1$\bar{3}$3, 403). Bakakinite is a natural analogue of synthetic Ca2V2O7. The mineral is named in honour of the outstanding Russian crystallographer and crystal chemist Vladimir Vasilievich Bakakin (born 1933).