bluuebunny/crossref_metadata_2025 huggingface dataset:
Cartas transatlánticas Un diálogo epistolar entre jóvenes sobre la violencia y la convivencia social en Euskadi y en EE.UU.
Authors: Rodríguez María Pilar ,   Universidad de Deusto, Lasa Maixabel , Atxaga Bernardo , Etxenike Luisa , García Arrizabalaga Iñaki , Ortiz-Ceberio Cristina , Pascual Esther
Published: February 2025

Este libro recoge las cartas que se escribieron a partir de las conversaciones que a través del correo electrónico y de sesiones de videoconferencia mantuvieron ocho jóvenes (en torno a los veinte años), tres de Dartmouth College (Lucas Joshi, Rachel Kent, Naren Radhakrishnan) y cinco de la Universidad de Deusto (Pablo Bellido, Paula del Barrio, Zuriñe Iglesias, Unai Murua y Naiara Nájera) en los meses de marzo a diciembre de 2020.

Es una iniciativa que surge de la colaboración entre dos profesoras y colegas, Annabel Martín (Dartmouth College) y María Pilar Rodríguez (Universidad de Deusto) al poner en contacto los estudiantes de ambas en el contexto de un seminario sobre el contexto post-ETA ofrecido en Dartmouth College.

El tema de las cartas es el de la violencia política y de los retos de la convivencia en Euskadi y en EE.UU. en sentido amplio. Las cartas reflexionan sobre el tipo de mundo que heredan estos jóvenes comprometidos con sus comunidades respectivas subrayando las experiencias personales vividas de cada uno. Las cartas son profundas, íntimas, con gran curiosidad por saber y aprender de los distintos contextos y exploran temas ligados a la violencia racial, las víctimas de la violencia política, la inmigración, el activismo político, el uso de violencia ante la lucha política, el miedo y la autocensura, la desobediencia civil, los efectos del capitalismo neoliberal sobre la vida en común, los derechos civiles, la identidad individual, entre otros.

El volumen se completa con una introducción de las dos editoras y un breve prólogo en el que Bernardo Atxaga presenta el libro y Maixabel Lasa escribe una carta dirigida a las nuevas generaciones.

El libro termina con un quinto capítulo donde la mediadora del proyecto de justicia restaurativa de Nanclares de Oca, Esther Pascual, la escritora Luisa Etxenike, la profesora Cristina Ortiz de la Universidad de Wisconsin-Green Bay, el ex dirigente de la oficina de víctimas del Gobierno Vasco, Txema Urkijo y el profesor de la Universidad de Deusto y víctima de ETA Iñaki García Arrizabalaga, reflexionan sobre los retos que plantea la convivencia social a los jóvenes de hoy.
El derecho a la autonomía alimentaria de los pueblos indígenas en México Una propuesta interdisciplinaria a partir del derecho a la alimentación y la libre determinación
Authors:   Universidad de Deusto, Fernández Molina María Victoria
Published: February 2025

A lo largo de este trabajo se realiza un ejercicio de justificación y construcción teórica y participativa de un concepto poco desarrollado desde la academia pero que, dadas sus características, contribuiría a la mejor protección de los sistemas alimentarios y los derechos de las comunidades indígenas: la autonomía alimentaria. En este sentido, el derecho propuesto se definiría como la facultad de las comunidades indígenas, y de cualesquiera otros campesinos, de producir alimento de forma independiente, manteniendo los métodos tradicionales basados en la sustentabilidad, para lograr satisfacer sus necesidades nutricionales y las de sus familias mediante sus propios recursos.
Validity of Optical Practicum KIT Equipped with Guided Inquiry-Based Worksheet for Madrasah Aliyah Students
Authors: Isnaniah Nur , Rahmawati Irma
Published: February 2025

The background of this research is the lack of supporting facilities for physics practicum activities, such as laboratories and teaching aids, so skills competence in optical material is not carried out. This study aimed to determine the validity of the Optical Practicum KIT with the validity of the Guided Inquiry-based worksheets. This study uses the Research and Development (R&D) method with the ADDIE model (Analyze, Design, Development, Implementation, and Evaluate). The data in this study are product validity obtained from 3 expert validators. The research results data were then analyzed using quantitative descriptive and qualitative descriptive analysis techniques. The results showed that the validity of the Optical Practicum KIT was stated to be very valid by the validator with a value of 84,83%, and the validity of the Guided Inquiry-based worksheet was also stated to be very valid with a value of 89,56%, so it was suitable for use as a physics learning medium. Hopefully, this research can be further refined in terms of construction and adding components such as microcontroller sensors, as well as implementing or testing products with experimental research.
Trójstyk cywilizacji – Anatolia w okresie kampanii Lucjusza Licyniusza Lukullusa (74–66 p.n.e.)
Authors: Jastrząbek Jakub
Published: February 2025

Anatolia była obszarem ścierania się trzech różnych kultur: rzymskiej, greckiej i wschodniej. Problematyka ta jest wyjątkowo dobrze widoczna na przykładzie III wojny mitrydatejskiej, która stanowiła rozstrzygnięcie trwającej od ponad pół wieku walki o dominację w regionie. Dowódcą Rzymian był Lucjusz Licyniusz Lukullus, wykształcony nobil i filhellen; walczył z Mitrydatesem VI, despotycznym władcą Pontu, który otrzymał później wsparcie króla Armenii Tigranesa II. W trakcie omawianych kampanii (oraz wcześniejszych dziesięcioleci) występują sytuacje, w których przedstawiciele trzech kultur wchodzą w konflikty. Jednocześnie dostrzec można przykłady współpracy tych grup, które zapowiadają ich przyszłe zbliżenie.
Wybór opinii źródłowych o kontaktach między krzyżowcami i Bizancjum w trakcie I i II krucjaty
Authors: Bartosiewicz Rafał
Published: February 2025

Krucjaty stanowią ciągle żywo dyskutowany temat w przestrzeni badawczej. W opinii publicznej dominuje przekonanie, które ma pewne odzwierciedlenie w literaturze naukowej, że to na barbarzyńskich krzyżowców spada całkowita odpowiedzialność za zepsucie relacji między Zachodem a Bizancjum, co doprowadziło do upadku Konstantynopola w 1204 r. Celem tego artykułu jest zweryfikowanie tego typu dotychczasowych przekonań i podjęcie refleksji nad aspektem politycznym, kulturowym, religijnym, mentalnym i militarnym relacji Bizancjum z członkami I i II krucjaty. Analiza tych kwestii pozwala zarówno na dokonanie rachunku zysków i strat obustronnych kontaktów, jak i na odszukanie strukturalnych problemów, jakie utrudniały wzajemne porozumienie.
Moments and Inferences based on Generalized Order Statistics from Benktander Type II Distribution
Authors: Anwar Zaki , Ali Zakir , Faizan Mohd , Khan Iftkhar
Published: February 2025

In this paper, we employ generalized order statistics to investigate the moment properties of the Benktander Type II distribution. Through this approach, we derive precise and explicit formulas for single moments and establish recurrence relations for single and product moments. Additionally, we present a characterization of the Benktander Type II distribution, accompanied by further implications regarding moments of record values and ordinary order statistics. We estimate the unknown parameters of the Benktander Type II distribution using Maximum Likelihood (ML) estimation for generalized order statistics (gos). Subsequently, we conduct simulation studies encompassing order statistics. The efficacy of the obtained ML estimates is evaluated through comprehensive simulation analyses, focusing on various moments and their relative mean squared errors. This research contributes to understanding the Benktander Type II distribution's properties and provides valuable insights into its parameter estimation using generalized order statistics.
A Hybrid Direction Method for Linear Fractional Programming
Authors: Hakmi Mohammed Amin , Bentobache Mohand , Bibi Mohand Ouamer
Published: February 2025

In this article, we propose a new method for solving Linear Fractional Programming (LFP) problems with bounded variables. The proposed algorithm passes from a support feasible solution to a better one following the feasible direction proposed in [K. Djeloud, M. Bentobache and M. O. Bibi, A new method with hybrid direction for linear programming, Concurrency and Computation, Practice and Experience 33 (1), 2021]. Optimality and suboptimality criteria which allow to stop the algorithm when an optimal or suboptimal solution is achieved were stated and proved. Then, a new method called a Hybrid Direction Method (HDM) is described and a numerical example is given for illustration purpose. In order to compare our method to the classical approaches, we develop an implementation with the Matlab programming language. The obtained numerical results on solving 120 randomly generated LFP test problems show that HDM with long step rule is competitive with the primal simplex method and the interior-points method implemented in Matlab.
Josso vive! Essencialidade da vida em Pesquisa-Formação com docentes e alunos
Authors: Abrahão Maria Helena Menna Barreto
Published: February 2025

O Seminário de Pesquisa-Formação realizado de modo remoto objetivou o desenvolvimento de estudo e reflexão crítica de um novo conceito – a essencialidade vital – relativo ao Paradigma da Identidade Evolutiva Singular Plural, de Marie-Christine Josso, que apresente significação para a reorganização da vida pós-Pandemia. Conceito, esse, a ser compreendido mediante construção de narrativas autobiográficas, no âmbito do desenvolvimento de pesquisa-formação, auscultando novas possibilidades de criação de tempo espaços reflexivos sobre mudanças inevitáveis que estão se construindo nesse período de incertezas à procura de um futuro sustentável para as pessoas em todos os sentidos da sobrevivência da vida biológica e ambiental, sociocultural, econômica e espiritual. Nessa esteira, foi instituído o seminário pela professora-pesquisadora constituído de um coletivo de docentes-pesquisadores oriundos de 25 universidades brasileiras, uma de universidade portuguesa, além de 12 doutorandos e uma mestranda, cursando Pós-graduação em universidades brasileiras e portuguesas. O clima amical e participativo durante o desenvolvimento do seminário contribuiu para participações substantivas e representativas desse coletivo de estudos permitindo a realização de momentos reflexivos criativos e constitutivos de entendimentos potentes a respeito de uma busca consciente do que possa representar o essencial vital em tempos incertos.
Evaluación del riesgo a la salud por la exposición a plaguicidas a través del consumo de tomate (Solanum lycopersicum L.), en Guasave, Sinaloa, México
Authors: Leyva-Morales José Belisario , Bastidas-Bastidas Pedro de Jesús , Rodríguez-Aguilar Brian Arturo , Davizon Yasser A. , Márquez-Pacheco Henri , Amillano-Cisneros Jesús Mateo , Godínez-Siordia Daniel Enrique , Lorente Adame Rogelia Guillermina , González-Márquez Luis-Carlos , Leyva Camacho Lucía , Salvatierra-Stamp Vilma del Carmen
Published: February 2025

El municipio de Guasave, Sinaloa, México, destaca por ser uno de los principales productores agrícolas a nivel nacional. Dentro de los productos cultivados sobresale el tomate, una hortaliza muy sensible al ataque de plagas, por lo que durante el establecimiento del cultivo se requiere el uso constante de plaguicidas químicos; éstos dejan residuos en el producto final que pueden representar un riesgo para el consumidor. En el presente estudio se monitoreó la presencia de residuos de plaguicidas en muestras de tomate producido localmente. Los plaguicidas se extrajeron mediante el método “rápido, fácil, barato, efectivo, resistente y seguro” (QuEChERS, por su sigla en inglés) y cuantificados mediante cromatografía de gases acoplada a los detectores de microcaptura de electrones y fotométrico de flama pulsada. Una vez conocida la concentración de analitos, se calculó la ingesta diaria estimada, la cual fue comparada con la ingesta diaria admisible para calcular el cociente de riesgo. Este último se estimó en dos escenarios, el general (concentración promedio) y el peor (concentración máxima). Los riesgos se estimaron tanto para niños como para adultos. Los resultados mostraron la presencia en los tomates de los plaguicidas metamidofos, lambda cialotrina, p,p’-DDE y malatión en concentraciones superiores al límite de cuantificación, aunque únicamente el malatión representó un riesgo aparente para la salud de los niños en los dos escenarios evaluados. Sin embargo, al considerar el efecto acumulativo de todos los plaguicidas encontrados, los adultos también podrían estar en riesgo por el consumo de esta hortaliza. Por ello, en México es recomendable la vigilancia exhaustiva de los residuos de plaguicidas en los productos agrícolas de consumo humano.
REPARIXIN AS A POTENTIAL ANTI-EPILEPTOGENIC AGENT: MODULATION OF CXCL1-CXCR1/2 AXIS AND SEIZURE ACTIVITY IN KINDLING MODEL OF TEMPORAL LOBE EPILEPSY
Authors: Carcak Nihan , Mutlu Nursima , Erdev Elif Tuğçe , Turan Taygun , Sarıyıldız Özge , Ulusoy Canan , Sanli Elif , Tuzun Erdem , Kucukali Cem Ismail , Brandolini Laura , Aramini Andrea , Allegretti Marcello , Onat Filiz , De Filippis Lidia
Published: February 2025

Chemokine (CXC motif) ligand 8 (CXCL8) is a pro-inflammatory chemokine binding to CXCR1/2 receptors, is elevated in the serum of patients with Temporal Lobe Epilepsy (TLE). Its murine ortholog CXCL1, is implicated in seizure generation and neuronal loss. This study evaluates the anti-epileptogenic and anti-seizure effect of reparixin, an allosteric CXCR1/2 antagonist in amygdaloid kindling rat model of TLE.
Reparixin was administered via osmotic pumps (8mg/kg/h) during kindling period over 14 days and seizures induced twice daily by electrical stimulation. To asses anti-seizure effects, fully kindled animals reparixin was given before stimulations at 24 and 48 hours post-implantation. Brain tissue was analyzed for CXCL1-CXCR1/2 axis activation.
Reparixin delayed secondary seizure generalization during kindling.. While it did not completely prevent kindling, reparixin reduced seizure severity and after-discharge duration in fully kindled animals at 24 hours post-treatment. CXCR1/2 and AKT pathway proteins showed no significant changes, reparixin reduced the phospho-ERK:ERK ratio in the cortex and hippocampus. CXCL1 expression was also significantly decreased in the cortex.
Reparixin exhibits anti-epileptogenic and partial anti-seizure effects by modulating the CXCL1-CXCR1/2 axis and reducing ERKsignalling, underscoring its potential as a neuroinflammation-targeting epilepsy treatment. Already in clinical trials for respiratory diseases, reparixin could be repurposed for epilepsy therapy.
Clinical Debates on Minimally Invasive Glaucoma Surgery (MIGS): Visual Function after Schlemm’s Canal-Based MIGS
Authors: Kasahara Masayuki , Shoji Nobuyuki
Published: February 2025

Filtration surgery is highly effective in lowering intraocular pressure; however, it is associated with a higher risk of severe complications. Visual dysfunction may persist in relatively uneventful cases because of induced astigmatism or worsening optical aberrations. Therefore, for early-to-moderate-stage glaucoma, an increasing number of surgeons are prioritizing surgical safety and preserving postoperative visual function by opting for minimally invasive glaucoma surgery (MIGS). Among the various MIGS techniques, canal opening surgery—targeting aqueous outflow through the Schlemm’s canal (Schlemm’s canal-based MIGS, CB-MIGS)—has gained increasing popularity. Unlike filtration surgery, CB-MIGS does not require creating an aqueous outflow pathway between the intraocular and extraocular spaces. Consequently, it is considered a minimally invasive procedure with a reduced risk of severe complications and is increasingly being chosen for suitable cases. Although this surgical technique has limitations in lowering intraocular pressure, it avoids the manipulation of the conjunctiva or sclera and is primarily performed through a small corneal incision. Therefore, minimal impact on induced astigmatism or postoperative refractive changes is expected. However, few reviews have summarized the changes in visual function, such as postoperative corrected visual acuity, refraction, astigmatism, or the effectiveness of visual field preservation. Therefore, we aimed to review the literature on visual function after CB-MIGS. Hyphema is the primary cause of early postoperative vision loss and is often transient in cases in which other complications would have led to visual impairment. Severe complications that threaten vision are rare. Additionally, compared with filtration surgery, postoperative visual recovery tends to be faster, and the degree of induced astigmatism is comparable to that of standalone cataract surgery. When combined with cataract surgery, the refractive error is at the same level as that of cataract surgery alone. However, in some cases, mild hyperopic shifts may occur because of axial length shortening, depending on the extent of intraocular pressure reduction. This possibility has been highlighted in several studies. Regarding the effectiveness of slowing the progression of visual field defects, most studies have focused on short- to medium-term postoperative outcomes. Many of these studies have reported sufficient suppression of progression rates. However, studies with large sample sizes and long-term prospective designs are limited. To establish more robust evidence, future research should focus on conducting larger-scale, long-term investigations.
The Interplay Between Organization and Organizing in Educational and Cultural Dynamics: A Review. Insights from European Countries
Authors: Covaci Mihai , Covaci Brindusa
Published: February 2025

This article revisits the foundational principles behind the concepts of organization and structure. Defining "organization" is particularly challenging, as existing terminology often fails to fully capture its complexity. Words like "organization" can be interchangeable with terms such as entity, connection, mechanism, social complex, and mode of administration, among others. However, relying solely on synonyms is insufficient, often leading to a cycle of circular definitions. Many interpretations tend to lean toward synonymous or circular explanations. As a result, it is essential to deepen our understanding of key concepts in contemporary society-organization and structure-to ensure conceptual clarity. By exploring these ideas, the article moves beyond mere linguistic equivalents, aiming to provide a comprehensive understanding of their multifaceted nature. The paper also examines the cultural dynamics within European countries and presents several organizational models.
Long Duration UAV Localization Cross Day and Night by Fusing Dual Vision Geo-Registration with Inertial Measurements
Authors: Xing Xuehui , He Xiaofeng , Liu Ke , Chen Zhizhong , Song Guofeng , Hao Qikai , Zhang Lilian , Mao Jun
Published: February 2025

Visual-inertial navigation plays a crucial role in autonomous flight in the Global Navigation Satellite System (GNSS) denied environment. However, most existing visual-aided navigation systems use visible images for localization, which is incapable of compensating the inertial drifts during the night. In this work, we develop a long-term localization system by fusing visi-ble/thermal visual geo-registration with inertial measurements. To achieve cross day and night localization performance, we propose to match both the onboard visible and thermal images to a remote RGB map. To deal with the large differences between visible and thermal images, we inspected various visual features and propose to utilize a pretrained network for cross domain feature extraction and matching. To obtain an accurate position from vision registration, we demonstrate a localization error compensation algorithm with considerations about the camera attitude, flight height, and terrain height. Finally, the inertial and dual vision information is fused with a State Transformation Extended Kalman Filter (ST-EKF) to generate long-term, drift-free localization performance. Finally, we conducted actual long-duration flight experi-ments with altitudes ranging from 700 to 2400 meters and flight distances longer than 344.6 kilometers. Experimental results have demonstrated that the proposed method’s localization error is less than 50 meters in RMSE.
Novel Triterpenes and Bioactive Compounds Isolated from Smilax canariensis Brouss
Authors: G. Díaz Jesús , Vega Samuel , Ganosa Daniel , Pérez de Paz P. , Diaz Diaz David
Published: February 2025

The aerial parts of Smilax canariensis Brouss., an endemic plant species of the Canary Islands and Madeira, were chemically investigated, resulting in the isolation of multiple known and novel compounds. These include three known flavonol glycosides: quercetin-3-O-rutinoside, rutin (7), quercetin-3-O-rutinoside decaacetate (7a), kaempferol-3-O-rutinoside nonaacetate, nicotiflorin acetate (8), 1-O-p-coumaroylglycerol triacetate (10) and trans-resveratrol (9). Additionally, a new sterol, 24,24- dimethy-5α-cholesta-7, 25-dien-3-one (1), and two novel dammarane–type triterpenes, 24-hydroxy-24-methyl-dammara-20,25-dien-3-one (2) and 3-acetyl-25-methyl-dammara-20,24-diene (3), were identified. In addition, stigmasterol, sitosterol and stigmast-4-en-3-one (4) were obtained. The structural elucidation of these compounds was achieved via 1D and 2D NMR spectroscopy, mass spectrometry, and comparison with literature data. This study provides the first phytochemical profile of S. canariensis and highlights its potential as a source of bioactive compounds for pharmacological applications.
Tooth Wear Prevalence and Associated Risk Factors Among a Small Portuguese Community: A Retrospective Study
Authors: Carvalho Rui , Rodrigues Sofia , Nobre Manuel , Rua João , Guerreiro Eduardo , Proença Luis , Vieira Ana Maria
Published: February 2025

Abstract: Background/Objectives: This study aims to study the prevalence of tooth wear (TW) in a sample of patients seeking the Screening and Urgency appointment at Egas Moniz Dental Clinic (EMDC) and correlate TW with risk factors. Methods: The database created with the collected information was used for descriptive and inferential statistical analysis. Data from 2266 patients, collected between 2021 and 2023, was analyzed for the presence of tooth wear, its different types and its correlation with risk factors. Results: The prevalence of dental wear was found to be 54.7%, with attrition (24.1%) being the most prevalent lesion, and erosion (2.7%) the least prevalent. Concerning risk predictors for tooth wear, age, decreased DVO, antacids, mastigation difficulties, drugs and use of mouthwash were positively associated. Conclusions: It was concluded that TW is prev-alent and increases with age, underscoring the necessity for timely and accurate diagnosis to minimise its progression. Additionally, it is crucial to conduct a thorough evaluation of the risk factors involved, to implement effective preventive measures and treatment strategies.
Bridging Theory and Practice: A Systems Approach to Childhood Sexual Abuse Prevention
Authors: McManus Clifford James
Published: February 2025

The prevalent public health and social issue of childhood sexual abuse (CSA) is a harmful offense affecting approximately one (1) out of every seven (7) children in the United States (U.S.) each year. While many advancements in prevention and intervention strategies since the 1980s have been noted, there remains a horrific number of gaps in the nation’s approaches to combating this pandemic. The barriers identified include underreporting, a considerable disconnect between CSA knowledge and cultural considerations, and an unfair and ongoing stigma surrounding CSA victimization. This literature establishes scholarly findings to conceptualize innovative tactics to combat CSA using a systems framework. With the systems-based approach as the foundation, multiple other frameworks reinforce practicality in prevention and intervention applications. The background of CSA reveals an interconnectedness among CSA victims and perpetrators by using trusted ecological factors to offend. The same revelations support the exploration of ecology and systems with primary and secondary prevention strategies, guiding a need for interconnectedness between the two frameworks to conceptualize CSA prevention and intervention. Overall, this paper delineates a comprehensive approach for effective CSA prevention, underscoring the importance of macro policy reform to enhance community cohesiveness in protecting vulnerable children against CSA.
Survivin Mediates Mitotic Onset in HeLa Cells Through Activation of the Cdk1-Cdc25B Axis
Authors: Canovas Pedro M.
Published: February 2025

The Survivin protein has roles in repairing incorrect microtubule-kinetochore attachments at prometaphase, and the faithful execution of cytokinesis, both as part of the chromosomal passenger complex (CPC). In its absence, mitotic errors often occur that lead to chromosome missegregation, a cause of aneuploidy, polyploidy and ultimately cancer. Adding to these well-known roles of Survivin, this paper now shows for the first time that this protein is required for cancer cells to enter mitosis, and that, in its absence, HeLa cells accumulate at early prophase, or prior to prometaphase as reported before. This early prophase blockage is demonstrated by the inability of Survivin-depleted cells to disassemble their nuclear lamina and their low Cdk1 activity. Importantly, escaping the arrest induced by the Survivin double mutant SUR D70A/D71A leads to multiple mitotic defects, or mitotic catastrophe, and eventually cell death. Mechanistically, Cdk1 does not localize at the centrosome in the absence of Survivin, pointing at this latter protein contributing to the activation of the mitotic kinase via Cdc25B. Furthermore, absence of Survivin leads to an inactive cytosolic Cdc25B-Cdk1-Cyclin B1 complex, which seems to indicate a role for Survivin in bridging this complex and its centrosomal activator/s. Interestingly, the drop in Cdc25B activity caused by interference with the Survivin’s function could be rescued when Survivin-depleted HeLa cell lysates were incubated with the recombinant Survivin protein. Also, a role for Survivin in the Cdc25B-mediated activation of Cdk1, and concomitant prophase to prometaphase transition could be confirmed by expression of a gain-of-function Cdc25B mutant, which overrode the G2/prophase blockage caused by Survivin depletion.
Interlinkages of Sustainability, Innovation, Market Integration, and Global Value Chain Governance in Ethiopia’s Integrated Agro-Industrial Parks
Authors: Boru Efa Muleta , Hwang Jun Seok , Ahmad Abdi Yuya
Published: February 2025

This study investigates the interconnections between sustainability practices, innovation, market integration, and Global Value Chain (GVC) governance within Ethiopia’s Integrated Agro-Industrial Parks (IAIPs). It addresses key challenges faced by IAIPs in promoting sustainability, fostering innovation, and achieving global market integration, providing insights into how sustainability-driven innovation can enhance market access and competitiveness. A quantitative, deductive research design was adopted, utilizing a stratified sampling technique across two IAIPs, Bulbula and Yirgalem. Data were collected through questionnaires from 160 respondents, and Partial Least Squares Structural Equation Modeling (PLS-SEM) was used to examine the direct and indirect relationships among sustainability, innovation, market integration, and GVC governance. The findings demonstrate that sustainability practices significantly promote innovation (β = 0.504, p < 0.001), which in turn boosts market integration (β = 0.422, p < 0.001) and strengthens GVC governance (β = 0.589, p < 0.001). Mediation analysis indicates that innovation partially mediates the effect of sustainability on market integration, while both innovation and market integration fully mediate sustainability’s impact on GVC governance. This research underscores the critical role of sustainability-driven innovation in improving market integration and GVC governance in IAIPs, suggesting that incorporating sustainability practices can enhance global competitiveness. The findings provide valuable insights for policymakers and industry stakeholders seeking to strengthen IAIPs' global market position.
A Secure and Integrated Approach to Software Code and Docker Image Signing: Introducing the Hybrid Chain of Trust (HCoT) Algorithm
Authors: Qureshi Jamshir
Published: February 2025

Securing the software supply chain is critical in an increasingly interconnected development environment, and vulnerabilities can have implications at a widespread level. Hybrid Chain of Trust (HCoT) algorithm, a proposed new solution, integrates cutting-edge technology to address such concerns. AI-facilitated code analysis in HCoT identifies a broader range of vulnerabilities compared to traditional methods. HCoT simplifies workflows through aggregation of code and image signatures under a single, unified process. HCoT also introduces transparency to the software delivery pipeline through having recordable, verifiable proofs of vulnerability and integrity of code. With these, security professionals and developers can make trust in software delivered to them a reality.
Traits of STEM Teachers for 21st Century STEM Education
Authors: Golegou Eirini , Wallace Manolis , Peppas Kostas
Published: February 2025

STEM education is a growing global trend, but what are the essential characteristics that should be cultivated in the curricula of the higher education institutions that teachers attend, as well as through the training programmes they follow throughout their careers? This literature review aims to identify the characteristics that a STEM educator should possess in order to achieve the goals of such education. Beyond basic pedagogical knowledge, educators themselves need to acquire 21st century skills. As mentors, they are responsible for setting a positive example for their students. A STEM classroom is characterised by democratic principles and the desire to find innovative solutions. The teacher is the intermediary between the goals of the educational system and their achievement. It is therefore essential to study the aspects of their training that can contribute to this direction.
Scaling Up Red Ginger Kombucha Fermentation: Insights into Its Chemical Profile and Health-Promoting Properties
Authors: Mulyani Hani , Artanti Nina , Yuniati Ratna , Yasman Yasman
Published: February 2025

Red ginger, a plant widely available in Indonesia, is known for its rich content of bioactive compounds, including flavonoids and phenolics, which are known for their strong antioxidant properties. This study explored the fermentation of red ginger extract with kombucha inoculum (SCOBY), aiming to evaluate its potential as a health-enhancing herb with antioxidant and antidiabetic properties by neutralizing free radicals and inhibiting α-glucosidase activity. This study included laboratory-scale (100 mL) and large-scale (10 L) fermentation using 10% red ginger concentration and 15% red ginger kombucha SCOBY for fermentation periods of 0, 7, and 14 days at room temperature. The analysis included sugar content (glucose, fructose, maltose), organic acids (acetic acid, lactic acid, gluconic acid), pH, total titrated acids, total polyphenols (Folin-Ciocalteu), and total flavonoids (AlCl3). Fermented red ginger kombucha showed high levels of acetic, lactic, and gluconic acids, along with minor components such as phenolic acids, vitamins, and enzymes, indicating its potential health benefits as a natural antioxidant. Red ginger kombucha showed significant antioxidant and antidiabetic activity, indicating its potential in managing conditions such as prediabetes and type 2 diabetes. The results of the fermented ginger study showed potential as a health drink with antioxidant and antidiabetic properties, through its ability to reduce free radicals and inhibit the activity of the enzyme α-glucosidase.
Recent Developments in Differentiation Therapy of Acute Myeloid Leukemia
Authors: Testa Ugo , Castelli Germana , Pelosi Elvira
Published: February 2025

Acute myeloid leukemia (AML) is characterized by clonal expansion of myeloid progenitors blocked at various stages of their differentiation process and drugs that bypass this differentiation block are therapeutically efficient, as supported by retinoic acid and arsenic trioxide in acute promyelocytic leukemia. However, the successful application of differentiation therapy to APL was not translated into clinical benefit for other non-APL subtypes of AML, in which intensive chemotherapy regimens represent the standard of care. However, the development of molecular studies has led to the identification of therapeutic targets (such as mutated proteins, deregulated pathways) have led to the generation of a new category of specific pharmacologic agents. Some of these agents, such as inhibitors of mutant isocitrate dehydrogenase (IDH1 and IDH2), Lysine-specific demethylase-1 (LSD1) and Menin have shown the capacity of inducing leukemic cell differentiation and a significant therapeutic efficacy.
The Effects of Core Training on Balance and Some Physical Performance in Tennis Players
Authors: KOROGLU Yaşar , Sitti Samet samet , Koç Kenan kenan , Yüce Soner soner , ÖKMEN Mehmet Şerif , Türkmen Mustafa mustafa , Tastan Isa isa , Koca Feyzullah feyzullah , KONCA Erkan , Ucar Mine mine
Published: February 2025

Tennis is an entertaining sport that includes a combination of technical, tactical and physical fitness components. The aim of the study was to investigate the effect of core training on anaerobic performance and some physical performance values of tennis players studying at university and training on certain days of the week. 30 students between the ages of 18-23 who were studying at Sivas Cumhuriyet University, participated in the study as experimental group (15 male ) and control group (15 male). Height, body weight, flamingo balance test, vertical jump test, balance and pro-agility test were applied to the subjects as pre-test and post-test. The experimental group practiced core training 3 times a week along with the tennis training 3 days a week. The control group participated only in tennis training. The study was conducted for 6 weeks. Since the data were normally distributed, independent sample t test was used to compare independent groups and paired sample t test was used to compare dependent groups. In the data obtained as a result of the research, it was determined that there was a significant difference in crunch, balance, vertical jump and agility values in the experimental group, and there was a significant difference in crunch, vertical jump and agility values in the control group but there was no difference in other variables. As a result, we can say that 6-week core trainings applied to tennis players have positive effects on physical performance, and trainers should include core trainings in their annual plans in order to increase and maintain performance in their studies.
Plant Secondary Metabolites—Central Regulators Against Abiotic and Biotic Stresses
Authors: Khan Ameer , Kanwal Farah , Fahad Muhammad , Tariq Leeza , Riaz Asad , Tanveer Muhammad , Zhang Guo-ping
Published: February 2025

Both biotic and abiotic stresses adversely affect plant growth and development, ultimately reducing agricultural productivity. Secondary metabolites (SMs) are essential compounds that contribute to plant survival by facilitating interactions with the environment. In response to both abiotic and biotic stresses, plants synthesize and accumulate SMs, which in turn trigger signaling pathways that lead to post-transcriptional modifications within plant cells. These changes activate a series of defense mechanisms that enhance the plant's resilience and adaptation to stress. SMs are instrumental in ensuring plant survival under challenging conditions by modulating the plant's defense systems to cope with environmental threats. Beyond their role in stress tolerance, SMs are also bioactive compounds with significant economic and health value. In this review, we explore the functions of various SMs, such as alkaloids, flavonoids, and phenolic acids in defense against abiotic and biotis stresses. Additionally, we discuss the potential of harnessing SMs in the genetic improvement of crop stress tolerance, highlighting their roles in advancing agricultural sustainability.
Suggestions Regarding the Orthodox Theological Education in the Universities from Romania
Authors: Vanca Dumitru
Published: February 2025

Exiled from the amphitheater of public universities, theological education at the university level în Romania remained confined to historical models hermetically isolated from everything that modern education meant. The air of change, felt in the interwar period (when the German model, infiltrated through the Faculty of Chernivtsi, tried to give a new vision) was quickly suppressed by the communist fog.In a so declared freedom of expression and in a sort of self management and determination, the universitarian education was in fact restrained to the single two enclaved universities (Sibiu and Bucharest), and having less and less contacts with the theological universities form Europe and from the entire world. So, the Romanian theological education remains unchanged from the beginning of 20th centrury and oriented more to the past than towards the future. And this situation, even today is quite similar. Although the number of disciplines has increased since the beginning of the last century, in reality the process is not due to a normal and natural growth in response to the modern systems of university education, but it was the result of the segmentation of some fundamental disciplines and the emergence of complementary disciplines.Starting from this reality, because of a considerable personal experience, our article proposes some reflections on this issue, suggesting few solutions, and even some structural changes in the architecture of theological education, aimed at improving the quality of graduates.
Social-Economic Correlates of Drug Use in Bucharest-Ilfov Region
Authors: Frusinoiu Paula-Ștefania , Banacu Cristian-Silviu , Georgescu Milica , Dabija Georgiana Ramona , Iliescu Ruxanda
Published: February 2025

The negative effects of drug are the focus of the attention of researchers and practitioners when called upon to provide effective responses based on drug use trend analysis and estimates of the costs and correlates of the illicit drug use. At individual level, drug use has serious damaging effects on personal health, social life, the educational and professional course, and turns the life of a drug user in an obstacle race, in which life is threatened with each new bad decision. Both practitioners and decision-makers at global and European level become more concern as the age of onset for drug use decreases and illicit drug use becomes one of the major causes of preventable losses in society. This purpose of the paper is to generalize the concept of social and economic correlates of drug use, with a special focus on family, and to place it in relation to the dynamic phenomenon of drug use, in the specific geographical area of Bucharest and Ilfov. Applications of the concept are included to emphasize the link between evidence and practice. The paper builds on the analysis of academic investigations conducted by various authors and publications of relevant institutions.
Large Dynamic Graph Processing with GPU-Accelerated Priority-Driven Differential Scheduling and Operation Reduction
Authors: Song Sangho , Choi Jihyeon , Cha Donghyeon , Lee Hyeonbyeong , Choi Dojin , Lim Jongtae , Bok Kyoungsoo , Yoo Jaesoo
Published: February 2025

Recently, there has been active research on utilizing GPUs for the efficient processing of large-scale dynamic graphs. However, challenges arise due to the repeated transmission and processing of identical data during dynamic graph operations. This paper proposes an efficient processing scheme for large-scale dynamic graphs in GPU environments with limited memory, leveraging dynamic scheduling and operation reduction. The proposed scheme partitions the dynamic graph and schedules each partition based on active and tentative active vertices, optimizing GPU utilization. Additionally, snapshots are employed to capture graph changes, enabling the detection of redundant edge and vertex modifications. This reduces unnecessary computations, thereby minimizing GPU workloads and data transmission costs. The scheme significantly enhances performance by eliminating redundant operations on the same edges or vertices. Performance evaluations demonstrate an average improvement of 280% over existing static graph processing techniques and 108% over existing dynamic graph processing schemes.
Depauperate Small Mammal Assemblages in the National Park Protecting Land-Bridge Island Habitats Are Shaped More by Topography than Plant Communities
Authors: Ciechanowski Mateusz , Wikar Zuzanna , Kowalewska Teresa , Wojtkiewicz Maksymilian , Brachman Julia , Sarnowski Bartosz , Borzym Katarzyna , Rydzyńska Amelia
Published: February 2025

Small mammal species assemble based mainly on plant communities but the structure of their assemblages is shaped by several other factors, modified by larger-scale geography. Despite their ecological significance, they are often neglected elements of biodiversity, therefore, even several Polish national parks have lacked extensive surveys. It also applies to the Wolin National Park (WNP), the only one located on a coastal marine island, known previously for its unique bat fauna. We surveyed small mammals of WNP by live- and pitfall trapping, identifying only nine species, the lowest species richness among five national parks of the region (the remaining hosted 11-13 species, based on trapping data only) and the rarefaction curve showed very low probability of increasing that number by future sampling. Such unexpected paucity of species is probably linked to insular isolation and the location of the park at the edge of regional distributions of the three species. Cluster analysis revealed the most peculiar feature of small mammal assemblages in WNP - a division of the Park into two landscape units, moraine hills and the alluvial delta, where predominant murids were, respectively, Apodemus flavicollis and Apodemus agrarius. That divergence appeared to affect the clustering more than vegetation at the trapping sites.
Climate Characterization and Prediction in Vulnerable Regions of the Ecuadorian Amazon
Authors: Chango-Sailema Wilson Gustavo , Paguay-Soxo Paul Xavier , Mazón-Fierro Mónica , Mazón-Fierro Guido , Sayago-Heredia Jaime Paúl
Published: February 2025

According to the Intergovernmental Panel on Climate Change (IPCC), a significant increase in climate change has been identified during the last decade, generating adverse impacts in Ecuador’s most vulnerable regions. Among these areas is the province of Orellana, particularly the cantons of Joya de los Sachas and Loreto, where agriculture constitutes the main economic activity. However, these localities face a lack of a continuous meteorological monitoring system, which hinders both climate prediction and the adequate planning of productive activities. In response to this problem, a comprehensive characterization of climatic variables and soil and water quality was carried out on experimental farms located in the San Carlos and La Paz parishes. To this end, historical and current meteorological data related to temperature, atmospheric pressure, precipitation, relative humidity, solar radiation, wind speed, and wind direction were collected. Additionally, the statistical analysis included multivariate hypothesis tests, such as MANOVA and MANCOVA, with the aim of identifying significant differences between the studied localities. In the water quality analysis, physicochemical and microbiological parameters were evaluated according to the specifications of Tables 1 and 3 of the Unified Text of Secondary Legislation of the Ministry of Environment (TULSMA). Complementarily, the parameters recommended by the National Institute of Agricultural Research (INIAP) were considered to evaluate soil quality. The results included monthly and annual descriptive graphs of the climatic variables, which evidenced significant differences between the analyzed cantons. On the other hand, although the soil data did not show relevant discrepancies, the water analysis revealed a seasonal increase in metal and microorganism concentrations, reflecting the influence of climatic variations on water resources. These temporal and geographical differences were evaluated using machine learning techniques, which allowed for the identification of more complex patterns and trends. The predictions for Loreto and Sacha coincided in several aspects, highlighting a clear trend towards the reduction of climate variability and greater stability in meteorological patterns. This behavior manifests itself in the attenuation of seasonal fluctuations in variables such as temperature, pressure, relative humidity, solar radiation, wind speed, and precipitation. Consequently, these changes could reflect a transition towards a more predictable and constant climate, with direct implications for agriculture, water resource management, and planning for extreme weather events.
The Blue Supergiant Problem and the Main-Sequence Width
Authors: Vink Jorick S , Oudmaijer Rene D
Published: February 2025

Using Gaia DR3 we derive new distances and luminosities for a sample of Galactic B supergiants which were thought to be post main-sequence (MS) objects from their HR diagram location beyond the terminal-age MS (TAMS). When applying the newer Gaia distances in addition to enhanced amounts of core-boundary mixing, aka convective overshooting, we show that these Galactic B supergiants are likely enclosed within the MS band, indicating an evolutionary stage of steady core hydrogen burning. We discuss the importance of considering enhanced overshooting and how vectors in the mass-luminosity plane (ML-plane) can be used to disentangle the effects of wind mass loss from interior mixing. We finish with the key message that any proposed solution to the BSG problem should consider not only an explanation for the sheer number of B supergiants inside the Hertzsprung gap, but should at the same time also account for the steep drop in rotation rates identified at spectral type B1 -- corresponding to an effective temperature of $\sim$21 kK, and for which two distinct families of solutions have been proposed.