bluuebunny/crossref_metadata_2025 huggingface dataset:
Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer
Authors: Hojo N. , Huisken A. L. , Wang H. , Chirshev E. , Kim N. S. , Nguyen S. M. , Campos H. , Glackin C. A. , Ioffe Y. J. , Unternaehrer J. J.
Published: June 2018

To develop effective therapies for advanced high grade serous ovarian cancer (HGSOC), understanding mechanisms of recurrence and metastasis is necessary. In this study, we define the epithelial/mesenchymal status of cell lines that accurately model HGSOC, and evaluate the therapeutic potential of targeting Snai1 (Snail), a master regulator of the epithelial/mesenchymal transition (EMT) in vitro and in vivo. The ratio of Snail to E-cadherin (S/E index) at RNA and protein levels was correlated with mesenchymal morphology in four cell lines. The cell lines with high S/E index (OVCAR8 and COV318) showed more CSC-like, motile, and chemoresistant phenotypes than those with low S/E index (OVSAHO and Kuramochi). We tested the role of Snail in regulation of malignant phenotypes including stemness, cell motility, and chemotherapy resistance: shRNA-mediated knockdown of Snail reversed these malignant phenotypes. Interestingly, the expression of let-7 tumour suppressor miRNA was upregulated in Snail knockdown cells. Furthermore, knockdown of Snail decreased tumour burden in an orthotopic xenograft mouse model. We conclude that Snail is important in controlling HGSOC malignant phenotypes and suggest that the Snail/Let-7 axis may be an attractive target for HGSOC treatment.
Times series analysis of age-specific tuberculosis at a rapid developing region in China, 2011–2016
Authors: Zhu Minmin , Han Guiyuan , Takiff Howard Eugene , Wang Jian , Ma Jianping , Zhang Min , Liu Shengyuan
Published: June 2018

The city of Shenzhen has recently experienced extraordinary economic growth accompanied by a huge internal migrant influx. We investigated the local dynamics of tuberculosis (TB) epidemiology in the Nanshan District of Shenzhen to provide insights for TB control strategies for this district and other rapidly developing regions in China. We analyzed the age-specific incidence and number of TB cases in the Nanshan District from 2011 to 2016. Over all, the age-standardized incidence of TB decreased at an annual rate of 3.4%. The incidence was lowest amongst the age group 0–14 and showed no increase in this group over the six-year period (P = 0.587). The fastest decreasing incidence was among the 15–24 age group, with a yearly decrease of 13.3% (β = 0.867, P < 0.001). In contrast, the TB incidence increased in the age groups 45–54, 55–54, and especially in those aged ≥65, whose yearly increase was 13.1% (β = 1.131, P < 0.001). The peak time of TB case presentation was in April, May, and June for all age groups, except in August for the 45–54 cohort. In the rapidly developing Nanshan District, TB control policies targeted to those aged 45 years and older should be considered. The presentation of TB cases appears to peak in the spring months.
Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
Authors: Balbinot Gustavo , Schuch Clarissa Pedrini , Jeffers Matthew S. , McDonald Matthew W. , Livingston-Thomas Jessica M. , Corbett Dale
Published: June 2018

A coordinated pattern of multi-muscle activation is essential to produce efficient reaching trajectories. Disruption of these coordinated activation patterns, termed synergies, is evident following stroke and results in reaching deficits; however, preclinical investigation of this phenomenon has been largely ignored. Furthermore, traditional outcome measures of post-stroke performance seldom distinguish between impairment restitution and compensatory movement strategies. We sought to address this by using kinematic analysis to characterize reaching movements and kinematic synergies of rats performing the Montoya staircase task, before and after ischemic stroke. Synergy was defined as the simultaneous movement of the wrist and other proximal forelimb joints (i.e. shoulder, elbow) during reaching. Following stroke, rats exhibited less individuation between joints, moving the affected limb more as a unit. Moreover, abnormal flexor synergy characterized by concurrent elbow flexion, shoulder adduction, and external rotation was evident. These abnormalities ultimately led to inefficient and unstable reaching trajectories, and decreased reaching performance (pellets retrieved). The observed reaching abnormalities in this preclinical stroke model are similar to those classically observed in humans. This highlights the potential of kinematic analysis to better align preclinical and clinical outcome measures, which is essential for developing future rehabilitation strategies following stroke.
Honeybees show adaptive reactions to ethanol exposure
Authors: Miler Krzysztof , Kuszewska Karolina , Privalova Valeriya , Woyciechowski Michal
Published: June 2018

The honeybee is being developed as a simple invertebrate model for alcohol-related studies. To date, several effects of ethanol consumption have been demonstrated in honeybees, but the tolerance effect, one of the hallmarks of alcohol overuse, has never been shown. Here, we confirm our hypothesis that the response to ethanol (in terms of motor impairment) is lower in bees that have previously experienced intoxication than in bees encountering ethanol for the first time, indicating that the chronic tolerance effect occurs in honeybees. Furthermore, we investigated the basis of this effect and found that it likely results from conditioned compensatory responses to cues associated with ethanol delivery. Our findings significantly improve our understanding of the suitability of honeybees as models for alcoholism-related research and underline the first and foremost function of all conditioned reactions – their adaptive value.
Retraction Note: The Analysis of the Influence of Odorant’s Complexity on Fractal Dynamics of Human Respiration
Authors: Namazi Hamidreza , Akrami Amin , Kulish Vladimir V.
Published: June 2018

Scientific Reports 6: Article number: 26948; published online: 31 May 2016; updated: 01 June 2018 This Article has been retracted by Scientific Reports at the request of Nanyang Technological University. An investigation at Nanyang Technological University found that ethical approval for the reported experiments was not sought from their Internal Review Board.
Retraction Note: The analysis of the influence of fractal structure of stimuli on fractal dynamics in fixational eye movements and EEG signal
Authors: Namazi Hamidreza , Kulish Vladimir V. , Akrami Amin
Published: June 2018

Scientific Reports 6: Article number: 26639; published online: 24 May 2016; updated: 01 June 2018 This Article has been retracted by Scientific Reports at the request of Nanyang Technological University. An investigation at Nanyang Technological University found that ethical approval for the reported experiments was not sought from their Internal Review Board.
Retraction Note: Mathematical Modelling and Prediction of the Effect of Chemotherapy on Cancer Cells
Authors: Namazi Hamidreza , Kulish Vladimir V. , Wong Albert
Published: June 2018

Scientific Reports 5: Article number: 13583; published online: 28 August 2015; updated: 01 June 2018 This Article has been retracted by Scientific Reports at the request of Nanyang Technological University. An investigation at Nanyang Technological University found that ethical approval for the reported experiments was not sought from their Internal Review Board.
Development of endogenous enzyme-responsive nanomaterials for theranostics
Authors: Mu Jing , Lin Jing , Huang Peng , Chen Xiaoyuan
Published: June 2018

This review summarizes the recent progress of endogenous enzyme-responsive nanomaterials based on different building blocks such as polymers, liposomes, small organic molecules, or inorganic/organic hybrid materials for theranostics.
Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: a review of contemporary practice strategies and knowledge gaps
Authors: Lee Loong Chuen , Liong Choong-Yeun , Jemain Abdul Aziz
Published: June 2018

This review highlights and discusses critically various knowledge gaps in classification modelling using PLS-DA for high dimensional data.
Nanoscale partitioning of paclitaxel in hybrid lipid–polymer membranes
Authors: Tuteja Mohit , Kang Minjee , Leal Cecilia , Centrone Andrea
Published: June 2018

Nanoscale chemical imaging reveals enhanced paclitaxel partitioning and release at lipid–polymer boundaries.
Highly sensitive and on-site NO2 SERS sensors operated under ambient conditions
Authors: Kim Sunho , Kim Dong-Ho , Park Sung-Gyu
Published: June 2018

This paper presents the first demonstration of highly sensitive and on-site SERS-based NO2 sensors with a detection limit of 0.1 ppm operated under ambient conditions.
Interval LASSO regression based extreme learning machine for nonlinear multivariate calibration of near infrared spectroscopic datasets
Authors: Shan Peng , Zhao Yuhui , Sha Xiaopeng , Wang Qiaoyun , Lv Xiaoyong , Peng Silong , Ying Yao
Published: June 2018

As a nonlinear multivariate calibration method, extreme learning machine (ELM) has recently received increasing attention for its fast learning speed and excellent generalized performance.
Recent advances in toner-based microfluidic devices for bioanalytical applications
Authors: Gabriel Ellen F. M. , Lucca Bruno G. , Duarte Gabriela R. M. , Coltro Wendell K. T.
Published: June 2018

Toner-based microfluidic devices have emerged as promising platforms for bioanalytical applications.
Horizontal black lipid bilayer membranes for studying pore-forming toxins
Authors: Frey C. M. , Barth H. , Kranz C. , Mizaikoff B.
Published: June 2018

The investigation of pore-forming proteins such as the toxin component C2IIa from the binaryClostridium botulinumtype C2 toxin is of particular interest for pharmaceutical applications,e.g., such as drug delivery into cells.
Fine-tuning of the metal work function by molecular doping
Authors: He Jin , Iagher Lior , Etgar Lioz , Avnir David
Published: June 2018

Fine tuning of the metal work function (WF) in the range of 1 eV by 3D molecular doping of metals.
A catalyst-free, temperature controlled gelation system for in-mold fabrication of microgels
Authors: Krüger Andreas J. D. , Köhler Jens , Cichosz Stefan , Rose Jonas C. , Gehlen David B. , Haraszti Tamás , Möller Martin , De Laporte Laura
Published: June 2018

Star-shaped poly(ethylene oxide-stat-propylene oxide) polymers are end-modified with amine and epoxy groups to produce anisometric microgels with adaptable mechanical and (bio)chemical properties and self-assembly behaviour.
The effect of crystal structure on the electromechanical properties of piezoelectric Nylon-11 nanowires
Authors: Choi Yeon Sik , Kim Sung Kyun , Williams Findlay , Calahorra Yonatan , Elliott James A. , Kar-Narayan Sohini
Published: June 2018

Mechanical and piezoelectric properties of Nylon-11 nanowires strongly depend on their crystal structure, which can be precisely controlled by template-assisted growth methods.
Synthesis and electrocatalytic properties for oxygen reduction of Pd4Fe nanoflowers
Authors: Lian Chao , Cheng Yunlv , Chen Lifang , Han Xiao , Lei Xiaojuan , Liu Yan , Wang Yuan
Published: June 2018

Hierarchical Pd4Fe alloy nanoflowers with nanosheet petals mainly exposed the (111) crystal plane were prepared by reducing palladium acetylacetonate with Fe(CO)5 and oleylamine. The novel nanomaterials may be emerging materials in electrochemical field by virtue of the advantage of hierarchical architectures and 2D alloy nanosheets.
Phase-transfer-catalysed asymmetric synthesis of 2,2-disubstituted 1,4-benzoxazin-3-ones
Authors: Pawliczek Martin , Shimazaki Yuto , Kimura Hidenori , Oberg Kevin M. , Zakpur Saman , Hashimoto Takuya , Maruoka Keiji
Published: June 2018

The phase-transfer-catalysed alkylation of 2-aryl-1,4-benzoxazin-3-ones was developed as a way for the synthesis of enantioenriched 2,2-disubstituted 1,4-benzoxazin-3-ones.
In(iii)⋯In(iii) short contacts: an unnoticed metallophilic interaction?
Authors: Echeverría Jorge
Published: June 2018

We report here the existence of particularly close contacts between In(iii) centres in the crystals of Lewis acid–base adducts that show features of d10⋯d10 closed-shell metallophilic interactions.
Highly Lewis acidic cationic alkaline earth metal complexes
Authors: Pahl Jürgen , Brand Steffen , Elsen Holger , Harder Sjoerd
Published: June 2018

“Naked” cationic β-diketiminate Mg and Ca complexes possess high Lewis acidities and bind strongly to neutral benzene or alkyne ligands.
Synthesis and controlled crystallization of in situ prepared poly(butylene-2,6-naphthalate) nanocomposites
Authors: Papageorgiou Dimitrios G. , Bikiaris Dimitrios N. , Papageorgiou George Z.
Published: June 2018

The polymorphic nature of poly(butylene-2,6-naphthalate) (PBN) and the in situ prepared PBN-based nanocomposites was thoroughly evaluated.
The role of phosphorylation and dephosphorylation of shell matrix proteins in shell formation: anin vivoandin vitrostudy
Authors: Du Jinzhe , Xu Guangrui , Liu Chuang , Zhang Rongqing
Published: June 2018

Phosphorylation of shell matrix proteins is critical for shell formationin vivoand can modulate calcium carbonate formationin vitro.
Thermal stability of dialkylimidazolium tetrafluoroborate and hexafluorophosphate ionic liquids: ex situ bulk heating to complement in situ mass spectrometry
Authors: Clarke Coby J. , Puttick Simon , Sanderson Thomas J. , Taylor Alasdair W. , Bourne Richard A. , Lovelock Kevin R. J. , Licence Peter
Published: June 2018

Competition between vaporization and thermal decomposition of ionic liquids can be influenced by sample mounting during in situ measurements.
Assessing the electron transfer and oxygen mass transfer of the oxygen reduction reaction using a new electrode kinetic equation
Authors: Yin Fengjun , Liu Yuan , Wang Chuan , Liu Hong
Published: June 2018

A new kinetic equation describing the full-scale polarizations, provides a facile approach for assessing ORR performance, highlighting oxygen-mass transfer evaluation.
The electronic structure and the nature of the chemical bond in CeO2
Authors: Maslakov Konstantin I. , Teterin Yury A. , Ryzhkov Mikhail V. , Popel Aleksej J. , Teterin Anton Yu. , Ivanov Kirill E. , Kalmykov Stepan N. , Petrov Vladimir G. , Petrov Peter K. , Farnan Ian
Published: June 2018

The scheme of the outer and inner valence molecular orbitals of CeO812−, reflecting the nearest environment of Ce4+ in CeO2.
Influence of the Ge distribution on the first order magnetic transition of the MnFe(P,Ge) magnetocaloric material
Authors: Zhang Zhen-Lu , Liu Dan-Min , Xiao Wei-Qiang , Li Hui , Wang Shao-Bo , Liang Yun-Tian , Zhang Hong-Guo , Li Shan-Lin , Fu Jun-Jie , Yue Ming
Published: June 2018

MnFe(P,Ge) is a promising magnetocaloric material for potential refrigeration applications near room temperature.
Successive C1–C2 bond cleavage: the mechanism of vanadium(v)-catalyzed aerobic oxidation of d-glucose to formic acid in aqueous solution
Authors: Niu Muge , Hou Yucui , Wu Weize , Ren Shuhang , Yang Ru
Published: June 2018

Successive C1–C2 bond cleavage was found via an isotope-labelling technique in the process of formic acid production from oxidation of bio-derived glucose catalyzed by homogeneous vanadium(v) species in aqueous medium.
Synthesis and photophysical properties of ruthenium(ii) polyimine complexes decorated with flavin
Authors: Guo Huimin , Zhu Lijuan , Dang Can , Zhao Jianzhang , Dick Bernhard
Published: June 2018

Phosphorescent emission from a flavin localized triplet excited state (3IL) is observed for the first time in a flavin decorated tris(dipyridine) Ru(ii) complex with strong visible light absorption.
Protonation state and fine structure of the active site determine the reactivity of dehydratase: hydration and isomerization of β-myrcene catalyzed by linalool dehydratase/isomerase from Castellaniella defragrans
Authors: Ling Baoping , Wang Xiya , Su Hao , Liu Rutao , Liu Yongjun
Published: June 2018

Linalool dehydratase/isomerase (LinD) from Castellaniella defragrans is a bifunctional enzyme that catalyzes the hydration of β-myrcene to (S)-linalool and isomerization of (S)-linalool to geraniol.
The dependence of the β-to-α phase transition behavior of poly(1,4-butylene adipate) on phase separated morphology in its blends with poly(vinylidene fluoride)
Authors: Hou Chunyue , Li Huihui , Sun Xiaoli , Yan Shouke , Wang Yanfang , Chen Shangtao
Published: June 2018

Two kinds of typical phase separated morphologies are prepared and they alter the stability of crystals.
A thermodynamic description for water, hydrogen fluoride and hydrogen dissolutions in cryolite-base molten salts
Authors: Wang Kun , Chartrand Patrice
Published: June 2018

This paper presents a quantitative thermodynamic description for water, hydrogen fluoride and hydrogen dissolutions in cryolite-base molten salts, which is of technological importance to the Hall–Héroult electrolytic aluminum extraction cell.
Probing the surface of γ-Al2O3 by oxygen-17 dynamic nuclear polarization enhanced solid-state NMR spectroscopy
Authors: Li Wenzheng , Wang Qiang , Xu Jun , Aussenac Fabien , Qi Guodong , Zhao Xingling , Gao Pan , Wang Chao , Deng Feng
Published: June 2018

Different (sub-)surface oxygen species of γ-Al2O3 are rapidly detected and differentiated by 17O dynamic nuclear polarization (DNP) surface enhanced solid state NMR spectroscopy.
Bimetallic catalysts for green methanol productionviaCO2and renewable hydrogen: a mini-review and prospects
Authors: Li Molly Meng-Jung , Tsang Shik Chi Edman
Published: June 2018

This mini review discusses the recent advancements in the use of bimetallic catalysts for green methanol productionviaCO2hydrogenation.
Prediction of morphological changes of catalyst materials under reaction conditions by combined ab initio thermodynamics and microkinetic modelling
Authors: Cheula Raffaele , Soon Aloysius , Maestri Matteo
Published: June 2018

Microkinetic modeling, ab initio thermodynamics and Wulff–Kaishew construction are used to predict catalyst structural changes under reaction conditions.
Facile surface improvement method for LaCoO3 for toluene oxidation
Authors: Yang Qilei , Wang Dong , Wang Chizhong , Li Xianfeng , Li Kezhi , Peng Yue , Li Junhua
Published: June 2018

LaCoO3 (LCO-0) perovskite catalysts were synthesized by the traditional citrate sol-gel method for toluene oxidation. The catalytic activity of the modified LaCoO3 (LCO-1) by acetic acid significantly increased.
The balance of electric field and interfacial catalysis in promoting water dissociation in bipolar membranes
Authors: Yan Zhifei , Zhu Liang , Li Yuguang C. , Wycisk Ryszard J. , Pintauro Peter N. , Hickner Michael A. , Mallouk Thomas E.
Published: June 2018

Bipolar membranes maintain a steady pH in electrolytic cells through water autodissociation at the interface between their cation- and anion-exchange layers. We analyze the balance of electric field and catalysis in accelerating this reaction.
Adsorption of selenium(vi) onto nano transition alumina
Authors: Jordan Norbert , Franzen Carola , Lützenkirchen Johannes , Foerstendorf Harald , Hering David , Weiss Stephan , Heim Karsten , Brendler Vinzenz
Published: June 2018

The adsorption of selenium(vi) onto nano transition alumina (γ/δ-Al2O3) was investigated at both macroscopic and molecular levels.
Artificial sweetener saccharin disrupts intestinal epithelial cells’ barrier function in vitro
Authors: Santos P. S. , Caria C. R. P. , Gotardo E. M. F. , Ribeiro M. L. , Pedrazzoli J. , Gambero A.
Published: June 2018

Consumption of non-nutritive sweeteners (NNS) is a dietary practice used by those who wish to lose weight or by patients on a sugar-restricted diet such as those with DM2.
Demonstrating a separation-free process coupling ionic liquid pretreatment, saccharification, and fermentation withRhodosporidium toruloidesto produce advanced biofuels
Authors: Sundstrom Eric , Yaegashi Junko , Yan Jipeng , Masson Fabrice , Papa Gabriella , Rodriguez Alberto , Mirsiaghi Mona , Liang Ling , He Qian , Tanjore Deepti , Pray Todd R. , Singh Seema , Simmons Blake , Sun Ning , Magnuson Jon , Gladden John
Published: June 2018

A lignocellulose to bisabolene bioconversion process is demonstrated to be fully compatible with [Ch][Lys].
Real-time observation of leukocyte–endothelium interactions in tissue-engineered blood vessel
Authors: Chen Z. , Tang M. , Huang D. , Jiang W. , Li M. , Ji H. , Park J. , Xu B. , Atchison L. J. , Truskey G. A. , Leong K. W.
Published: June 2018

Human cell-based 3D tissue constructs play an increasing role in disease modeling and drug screening.
A study of the interaction between inverted cucurbit[6]uril and symmetric viologens
Authors: Bai Dong , Gao Zhongzheng , Tao Zhu , Xiao Xin , Prior Timothy J. , Wei Gang , Liu Qingyun , Redshaw Carl
Published: June 2018

The interaction between inverted cucuribit[6]uril (iQ[6]) and a series of symmetric viologens bearing aliphatic substituents, namely dicationic dialkyl-4,4′-bipyridinium guests where the alkyl substituent is CH3(CH2)n (n = 1, 3 and 5) or benzyl, has been studied in aqueous solution.
Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants
Authors: Minami Atsushi , Ozaki Taro , Liu Chengwei , Oikawa Hideaki
Published: June 2018

The cyclization mechanisms and structural diversification strategies of novel cyclopentane-forming terpene synthases from various organisms are reviewed.
In situ chemical probing of hole defects and cracks in graphene at room temperature
Authors: Altan Ali I. , Chen Jian
Published: June 2018

The vacancy defects in CVD-grown graphene can be visualized under SEM after the solid–gas phase reaction between H2S gas and exposed copper substrate in the air at room temperature.
Direct synthesis of graphene on silicon oxide by low temperature plasma enhanced chemical vapor deposition
Authors: Muñoz Roberto , Martínez Lidia , López-Elvira Elena , Munuera Carmen , Huttel Yves , García-Hernández Mar
Published: June 2018

Direct, low temperature, catalyst-free and transfer-free growth of monolayer graphene films on silicon wafer with a native oxide.
Sulfur-rich covalent triazine polymer nanospheres for environmental mercury removal and detection
Authors: Fu Yu , Yu Wenguang , Zhang Weijie , Huang Qiao , Yan Jun , Pan Chunyue , Yu Guipeng
Published: June 2018

We describe a facile one-pot synthesis of porous covalent sulfide-bridged polytriazine nanospheres (NOP-28), which can be employed as highly efficient sorbents and at the same time act as selective sensitive sensors towards trace Hg2+.
Construction of PLGA/JNK3-shRNA nanoparticles and their protective role in hippocampal neuron apoptosis induced by oxygen and glucose deprivation
Authors: Zheng Jin , Qi Jianguo , Zou Quan , Zhang Zhenzhong
Published: June 2018

C-Jun N-terminal kinase 3 (JNK3) activation plays an essential role in the pathophysiology of cerebral ischemia.
Tetrakis(ethyl-4(4-butyryl)oxyphenyl)porphyrinato zinc complexes with 4,4′-bpyridin: synthesis, characterization, and its catalytic degradation of Calmagite
Authors: Soury Raoudha , Jabli Mahjoub , Saleh Tawfik A. , Abdul-Hassan Wathiq Sattar , Saint-Aman Eric , Loiseau Frédérique , Philouze Christian , Nasri Habib
Published: June 2018

This work reports on the synthesis and characterization of a new porphyrins complex:[Zn(TEBOP)(4,4′-bpy)](4,4′-bipyridine)(5,10,15,20-(tetraethyl-4(4-butyryl)oxyphenyl)porphyrinato)zinc(ii)(3).
Preparation and characterization of erythrocyte membrane cloaked PLGA/arsenic trioxide nanoparticles and evaluation of theirin vitroanti-tumor effect
Authors: Su Jing , Liu Geyi , Lian Yumei , Kamal Zul , Que Xiao , Qiu Yujiao , Qiu Mingfeng
Published: June 2018

Arsenic trioxide (ATO) is used for acute promyelocytic leukemia (APL) that is resistant to all-trans-retinoic acid, but its direct intravenous injection sometimes induces severe toxic side effects.
A lab-on-a-chip for preconcentration of bacteria and nucleic acid extraction
Authors: Hügle M. , Dame G. , Behrmann O. , Rietzel R. , Karthe D. , Hufert F. T. , Urban G. A.
Published: June 2018

A lab-on-a-chip combining free-flow electrophoretic preconcentration and thermoelectric lysis of bacteria as well as purification of nucleic acids by gel-electrophoresis.
Striking the right balance of intermolecular coupling for high-efficiency singlet fission
Authors: Pensack Ryan D. , Tilley Andrew J. , Grieco Christopher , Purdum Geoffrey E. , Ostroumov Evgeny E. , Granger Devin B. , Oblinsky Daniel G. , Dean Jacob C. , Doucette Grayson S. , Asbury John B. , Loo Yueh-Lin , Seferos Dwight S. , Anthony John E. , Scholes Gregory D.
Published: June 2018

Bulky side chains promote a molecular packing and intermolecular coupling that effect high-efficiency singlet fission in amorphous solids of pentacene derivatives.
Rapid photoinduced charge injection into covalent polyoxometalate–bodipy conjugates
Authors: Black Fiona A. , Jacquart Aurélie , Toupalas Georgios , Alves Sandra , Proust Anna , Clark Ian P. , Gibson Elizabeth A. , Izzet Guillaume
Published: June 2018

A series of redox tunable polyoxometalate–bodipy conjugates display variable charge transfer dynamics occuring down to 54 ps.
Investigation and regulation of self-assembled well-ordered nano/microstructures via an aromatic α-amino acid
Authors: Moazeni Maryam , Karimzadeh Fathallah , Kermanpur Ahmad
Published: June 2018

In order to invent notable biomaterials, in this research d-phenylalanine as an aromatic α-amino acid has been studied for the synthesis of well-ordered self-assembled architectures such as wires, tubes and sheets under different synthesis conditions.
Scalable synthesis of porous hollow CoSe2–MoSe2/carbon microspheres for highly efficient hydrogen evolution reaction in acidic and alkaline media
Authors: Wang Bo , Wang Zegao , Wang Xinqiang , Zheng Binjie , Zhang Wanli , Chen Yuanfu
Published: June 2018

Spray drying and selenization were employed to synthesize CoSe2–MoSe2/rGO-C (CS-MS/rGO-C), which delivers superior HER performance in acidic and alkaline media.
Revealing the effects of molecular packing on the performances of polymer solar cells based on A–D–C–D–A type non-fullerene acceptors
Authors: Li Shuixing , Zhan Lingling , Zhao Wenchao , Zhang Shuhua , Ali Basharat , Fu Zhisheng , Lau Tsz-Ki , Lu Xinhui , Shi Minmin , Li Chang-Zhi , Hou Jianhui , Chen Hongzheng
Published: June 2018

The molecular packing of three new non-fullerene acceptors with various benzene-based cores is systematically studied with the best power conversion efficiency of 11.49%.
Porous organic materials with ultra-small pores and sulfonic functionality for xenon capture with exceptional selectivity
Authors: Li Jialu , Huang Ling , Zou Xiaoqin , Zheng Anmin , Li Huiyan , Rong Huazhen , Zhu Guangshan
Published: June 2018

Exceptional selectivity and high adsorption capacity for xenon have been realized by simultaneously introducing plenty of narrow pores and engineering the pore surface with sulfonic functionality.
Interface design for enhancing the wettability of liquid metal to polyacrylate for intrinsically soft electronics
Authors: Wu Yun-hui , Xing Shu-ting , Zheng Rong-min , Liu Shu-qi , Deng Zhi-fu , Liu Hai-zhou , Wang Ping-ping , Liu Lan
Published: June 2018

A novel adhesive interface structure between EGaInSn and PA with high stretchability and stable conductivity for high performance soft electronics.
Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism
Authors: Li Pengpeng , Xu Dongqing , Ma Tiequn , Wang Daoying , Li Weidong , He Jianhua , Ran Tingting , Wang Weiwu
Published: June 2018

The type VI secretion system (T6SS) is a versatile and widespread export system found in many Gram-negative bacteria that delivers effector proteins into target cells. The functions of T6SSs are tightly regulated by diverse mechanisms at multiple levels, including post-translational modification through threonine phosphorylation via the Ser/Thr protein kinase (STPK) PpkA. Here, we identified that PpkA is essential for T6SS secretion in Serratia marcescens since its deletion eliminated the secretion of haemolysin co-regulated protein, while the periplasmic and transmembrane portion of PpkA was found to be disposable for T6SS secretion. We further determined the crystal structure of the kinase domain of PpkA (PpkA-294). The structure of PpkA-294 was determined in its apo form to a 1.6 Å resolution as well as in complex with ATP to a 1.41 Å resolution and with an ATP analogue AMP-PCP to a 1.45 Å resolution. The residues in the activation loop of PpkA-294 were fully determined, and the N-terminus of the loop was folded into an unprecedented inhibitory helix, revealing that the PpkA kinase domain was in an auto-inhibitory state. The ternary MgATP–PpkA-294 complex was also inactive with nucleotide ribose and phosphates in unexpected and unproductive conformations. The αC-helix in the inactive PpkA-294 adopted a conformation towards the active site but with the conserved glutamate in the helix rotated away, which we suggest to be a general conformation for all STPK kinases in the inactive form. Structural comparison of PpkA with its eukaryotic homologues reinforced the universal regulation mechanism of protein kinases.
Molecular insights of inhibition in sickle hemoglobin polymerization upon glutathionylation: hydrogen/deuterium exchange mass spectrometry and molecular dynamics simulation-based approach
Authors: Das Rajdeep , Mitra Amrita , Mitra Gopa , Maity Dibyajyoti , Bhat Vijay , Pal Debnath , Ross Cecil , Kurpad Anura V. , Mandal Amit Kumar
Published: June 2018

In sickle cell anemia, polymerization of hemoglobin in its deoxy state leads to the formation of insoluble fibers that result in sickling of red blood cells. Stereo-specific binding of isopropyl group of βVal6, the mutated amino-acid residue of a tetrameric sickle hemoglobin molecule (HbS), with hydrophobic groove of another HbS tetramer initiates the polymerization. Glutathionylation of βCys93 in HbS was reported to inhibit the polymerization. However, the mechanism of inhibition in polymerization is unknown to date. In our study, the molecular insights of inhibition in polymerization were investigated by monitoring the conformational dynamics in solution phase using hydrogen/deuterium exchange-based mass spectrometry. The conformational rigidity imparted due to glutathionylation of HbS results in solvent shielding of βVal6 and perturbation in the conformation of hydrophobic groove of HbS. Additionally, molecular dynamics simulation trajectory showed that the stereo-specific localization of glutathione moiety in the hydrophobic groove across the globin subunit interface of tetrameric HbS might contribute to inhibition in polymerization. These conformational insights in the inhibition of HbS polymerization upon glutathionylation might be translated in the molecularly targeted therapeutic approaches for sickle cell anemia.
fault detection for linear discrete‐time descriptor systems
Authors: Han Weixin , Wang Zhenhua , Shen Yi , Liu Yipeng
Published: June 2018

Sensor fault detection of discrete‐time descriptor systems with bounded disturbances is studied. The authors propose a new structure of a fault detection observer by augmenting the output, which can broaden the application scope. A criterion is used to achieve the fault sensitivity and disturbance attenuation ability of the residual simultaneously. The residual generation and time‐varying threshold calculation are integrated together based on analysis. Furthermore, sufficient conditions for the performance of the proposed observer are formulated in terms of linear matrix inequalities. Numerical simulations of a direct current motor and a flight vehicle are conducted to verify the applicability of the proposed fault detection observer design method.
Actuator fault reconstruction based on a robust adaptive observer
Authors: Han Zhiguo , Zhang Ke , Liu Haipeng
Published: June 2018

A fault reconstruction method based on a robust adaptive observer is proposed to handle the actuator additive faults that exist in a non‐linear descriptor system that satisfies the Lipschitz conditions. First, a robust adaptive fault reconstruction observer is proposed. This method has the desired robust performance and can achieve accurate reconstructions of both abrupt and time‐varying faults in the presence of an external unknown disturbance. Then, to improve the transition process of fault reconstruction, an improved robust adaptive fault reconstruction observer is proposed. The improved robust adaptive fault reconstruction algorithm, which uses different coefficients for the proportion output errors and the derivative output errors, can enhance the rapidity and accuracy of fault reconstruction. The robust adaptive and improved robust adaptive observers are based on the linear matrix inequality technique. According to the Lyapunov stability theory, the stability conditions of the methods are derived. Additionally, the influence of an external unknown disturbance on the actuator fault reconstruction is suppressed using a robust method. Finally, two different examples are used to demonstrate the effectiveness of the proposed fault reconstruction methods.
Motion and illumination defiant cut detection based on Weber features
Authors: Kar Tejaswini , Kanungo Priyadarshi
Published: June 2018

The spontaneous proliferation of video data necessitates implementing hierarchical structures for various content management applications. Temporal video segmentation is the key towards such management. To address the problem of temporal segmentation, the current communication exploits the concept of psychological behaviour of the human visual system. Towards this goal an abrupt cut detection scheme has been proposed based on Weber's law which provides a strong spatial correlation among the neighbouring pixels. Thus, the authors provide a robust and unique solution for abrupt shot boundary detection when the frames are affected partially or fully by flashlight, fire and flicker, high motion associated with an object or camera. Further, they have devised a model for generating an automatic threshold, taking into account the statistics of the feature vector which quadrates itself with the variation in the contents of the video. The effectiveness of the proposed framework is validated by exhaustive comparison with few contemporary and recent approaches by using benchmark datasets TRECVID 2001, TRECVID 2002, TRECVID 2007 and some publicly available videos. The results obtained give credence to the remarkable improvement in the performance while preserving a good trade‐off between missed hits and false hits as compared to the state‐of‐the‐art methods.
Revisiting the case of R Monocerotis: Is CO removed at R < 20 au?
Authors: Alonso-Albi T. , Riviere-Marichalar P. , Fuente A. , Pacheco-Vázquez S. , Montesinos B. , Bachiller R. , Treviño-Morales S. P.
Published: June 2018

Context. To our knowledge, R Mon is the only B0 star in which a gaseous Keplerian disk has been detected. However, there is some controversy about the spectral type of R Mon. Some authors propose that it could be a later B8e star, where disks are more common.

Aims. Our goal is to re-evaluate the R Mon spectral type and characterize its protoplanetary disk.

Methods. The spectral type of R Mon has been re-evaluated using the available continuum data and UVES emission lines. We used a power-law disk model to fit previous 12CO 1 →0 and 2 →1 interferometric observations and the PACS CO data to investigate the disk structure. Interferometric detections of 13CO J = 1 →0, HCO+ 1 →0, and CN 1 →0 lines using the IRAM Plateau de Bure Interferometer (PdBI) are presented. The HCN 1 →0 line was not detected.

Results. Our analysis confirms that R Mon is a B0 star. The disk model compatible with the 12CO 1 →0 and 2 →1 interferometric observations falls short of predicting the observed fluxes of the 14 < Ju < 31 PACS lines; this is consistent with the scenario in which some contribution to these lines is coming from a warm envelope and/or UV-illuminated outflow walls. More interestingly, the upper limits to the fluxes of the Ju > 31 CO lines suggest the existence of a region empty of CO at R ≲ 20 au in the protoplanetary disk. The intense emission of the HCO+ and CN lines shows the strong influence of UV photons on gas chemistry.

Conclusions. The observations gathered in this paper are consistent with the presence of a transition disk with a cavity of Rin ≳ 20 au around R Mon. This size is similar to the photoevaporation radius that supports the interpretation that UV photoevaporation is main disk dispersal mechanism in massive stars
Tracing the evolution of radiation-MHD simulations of solar and stellar atmospheres in the Lagrangian frame
Authors: Leenaarts Jorrit
Published: June 2018

Context. Radiation magnetohydrodynamics (radiation-MHD) simulations have become a standard tool for investigating the physics of solar and stellar atmospheres.

Aims. The aim of this paper is to present a method that allows the efficient and accurate analysis of flows in such simulations in the Lagrangian frame.

Methods. This paper presents a method that allows the construction of pathlines given a seed point that can be chosen freely at any location and at any time during the simulation where the simulation state is stored. The method is based on passive tracer particles. Through injection of particles in expanding regions the occurrence of particle-free volumes is avoided, even in the case of strongly compressive flows.

Results. The method was implemented in the solar and stellar atmosphere simulation code Bifrost. It is efficient and accurate. As examples I present an analysis of a gas parcel in the convection zone and a particle in the solar transition region.
Molecular gas in the northern nucleus of Mrk 273: Physical and chemical properties of the disc and its outflow
Authors: Aladro R. , König S. , Aalto S. , González-Alfonso E. , Falstad N. , Martín S. , Muller S. , García-Burillo S. , Henkel C. , van der Werf P. , Mills E. , Fischer J. , Costagliola F. , Krips M.
Published: June 2018

Aiming to characterise the properties of the molecular gas in the ultra-luminous infrared galaxy Mrk 273 and its outflow, we used the NOEMA interferometer to image the dense-gas molecular tracers HCN, HCO+, HNC, HOC+and HC3N at ∼86 GHz and ∼256 GHz with angular resolutions of 4ʺ̣9 × 4ʺ̣5 (∼3.7 × 3.4 kpc) and 0ʺ̣61 × 0ʺ̣55 (∼460 × 420 pc). We also modelled the flux of several H2O lines observed withHerschelusing a radiative transfer code that includes excitation by collisions and far-infrared photons. The disc of the Mrk 273 north nucleus has two components with decoupled kinematics. The gas in the outer parts (R∼ 1.5 kpc) rotates with a south-east to north-west direction, while in the inner disc (R∼ 300 pc) follows a north-east to south-west rotation. The central 300 pc, which hosts a compact starburst region, is filled with dense and warm gas, and contains a dynamical mass of (4 −5) × 109 M⊙, a luminosity ofL′HCN= (3–4) × 108K km s−1pc2, and a dust temperature of 55 K. At the very centre, a compact core withR∼ 50 pc has a luminosity ofLIR= 4 × 1011 L⊙(30% of the total infrared luminosity), and a dust temperature of 95 K. The core is expanding at low velocities ∼50–100 km s−1, probably affected by the outflowing gas. We detect the blue-shifted component of the outflow, while the red-shifted counterpart remains undetected in our data. Its cold and dense phase reaches fast velocities up to ∼1000 km s−1, while the warm outflowing gas has more moderate maximum velocities of ∼600 km s−1. The outflow is compact, being detected as far as 460 pc from the centre in the northern direction, and has a mass of dense gas ≤8 × 108 M⊙. The difference between the position angles of the inner disc (∼70°) and the outflow (∼10°) indicates that the outflow is likely powered by the AGN, and not by the starburst. Regarding the chemistry in Mrk 273, we measure an extremely low HCO+/HOC+ratio of 10 ± 5 in the inner disc of Mrk 273.
Multi-usage familial et agriculture de firme sur les rives du lac Tchad : une comparaison des performances économiques
Authors: Rangé Charline , Cochet Hubert
Published: June 2018

L’agriculture de firme et les modèles de type « révolution verte » sont promus par les pouvoirs publics pour la hausse de la production, de la croissance et de l’emploi qu’ils sont censés offrir dans les pays du Sud. Partant du cas des rives camerounaises du lac Tchad, cet article propose une comparaison, rarement faite, de deux modes de mise en valeur d’un même milieu relevant de logiques économiques et sociales radicalement différentes : le multi-usage agro-halio-pastoral de l’espace (mode d’exploitation actuel) et la monoculture de maïs (projet d’agropôle). En s’appuyant sur les fondamentaux que sont l’étude des pratiques agro-halio-pastorales et l’analyse du processus de création de la valeur ajoutée, l’article montre que le système familial actuel dégage une richesse équivalente à celle attendue de la firme tout en créant trois fois plus d’emplois et en offrant de meilleurs revenus.
Éducation thérapeutique du patient diabétique non francophone sur le lieu de résidence
Authors: Tessier Stéphane , Lindivat Anaëlle
Published: June 2018

De plus en plus d’anciens travailleurs migrants passent leur retraite en France malgré, pour certains, une faible francophonie. Si leur accès aux soins est relativement aisé, cette mauvaise connaissance du français les exclut des accompagnements éducatifs. Comme toute la population, ces retraités souffrent de pathologies chroniques avec en particulier une grande prévalence du diabète. L’objectif du projet est donc d’amener cet accompagnement éducatif au plus près des patients sur leur lieu de vie, en ayant recours à des traducteurs locaux. L’arrivée d’une médiatrice sociale au sein d’un très gros foyer (550 places) à Vitry-sur-Seine a permis de mobiliser les patients et les traducteurs autour d’une série de 5 séances thématisées et traduites en Bambara et en Soninké. Ces sessions ont été préparées en amont par une formation spécifique des traducteurs et l’envoi de leur contenu par écrit. Le succès de l’action formulé tant par les patients que par les traducteurs et la médiatrice sociale pousse à la renouveler autour des questions cardiovasculaires. Les enjeux éthiques et méthodologiques d’un tel dispositif sont discutés, en particulier dans la lutte contre les inégalités sociales de santé.
The Twisted Nose: What to Do When It's Not Straight
Authors: Gonzalez Joseph , Winkler Andrew
Published: June 2018

Septorhinoplasty is among the most common facial plastic and reconstructive surgeries and its complexities are reflected in a relatively high revision rate. The patient with a postoperative twisted nose presents an additional challenge and requires that the surgeon display empathy and possess a deep knowledge of the aesthetic and functional intricacies of the nose. Correction of the twisted nose should be approached in a systematic fashion with unique considerations for each “third” of the nose. While there are many options in the overall surgical armamentarium, each surgeon will find specific techniques that are most efficacious and reproducible for their individual practice. This article discusses select surgical “pearls” and techniques that can aid the surgeon in their own surgical decision-making.
Failure of Synthetic Implants: Strategies and Management
Authors: Kim Shin , Alharethy Sami , Jang Yong
Published: June 2018

Dorsal augmentation with synthetic implants is the most commonly performed rhinoplasty procedure, especially in the East-Asian region. However, as in all other surgical procedures, complications are inevitable. Complications that need to be managed surgically include displacement, deviation, suboptimal aesthetic outcome, extrusion, inflammation, infection, and changes in skin quality. Most complications can be easily managed with revision surgery. After the removal of the synthetic implant from the nasal dorsum, different dorsal implant materials such as dermofat, alloderm, or fascia-wrapped diced cartilage, conchal cartilage with perichondrial attachment, and costal cartilage are preferred. An irreversible change in the skin/soft tissue envelope poses a challenge that usually requires reconstructive surgery with a local flap. Therefore, early detection and prompt management of the complication are essential for minimizing the severity of the deformity and the complexity of the surgical procedures.
Primary Pericardial Mesothelioma an Oncological Rarity
Authors: Kumar R , Surabhi Sai ,   Avinash,   Ramakrishna
Published: June 2018

Primary pericardial mesothelioma is a rare and lethal tumor, with a reported prevalence of <0.002% [1]. Pleural and pericardial mesotheliomas, which are far more common are usually associated with exposure to asbestos. However, the cause of pericardial mesothelioma is less clear [2] and is influenced by other factors like genetic predisposition, immunological impairment, infection, radiation, dietary factors and recurrent serosal inflammation [3]. Clinical manifestations of the neoplasm include constrictive pericarditis, cardiac tamponade, and heart failure. Because of late presentation and few treatment approaches, primary pericardial mesothelioma carries a poor prognosis. In this paper, we present a case of primary pericardial mesothelioma in a 46 year female presenting as recurrent pericardial effusion along with constrictive pericarditis.
Existence of solutions for a generalized Yang–Mills–Higgs theory
Authors: Zhang Ruifeng
Published: June 2018

In this paper, the monopoles which are topological solitons in three space dimensions of k-field theories is studied. It is explicitly constructed that the magnetic monopoles arising in the recent study of Casana, Ferreira, and Hora of a generalized Yang–Mills–Higgs model which is controlled by the special positive function f. Using a variational method, we prove the existence of the finite-energy monopoles solution in the non-Abelian gauge field is proven. In particular, it is shown that, under the condition of the special weight function f, the finite-energy solution must be Bogomolnyi–Prasad–Sommerfield solution.
Extremal flows in Wasserstein space
Authors: Conforti Giovanni , Pavon Michele
Published: June 2018

We develop an intrinsic geometric approach to the calculus of variations in the Wasserstein space. We show that the flows associated with the Schrödinger bridge with general prior, with optimal mass transport, and with the Madelung fluid can all be characterized as annihilating the first variation of a suitable action. We then discuss the implications of this unified framework for stochastic mechanics: It entails, in particular, a sort of fluid-dynamic reconciliation between Bohm’s and Nelson’s stochastic mechanics.
Inter-satellite laser link acquisition with dual-way scanning for Space Advanced Gravity Measurements mission
Authors: Zhang Jing-Yi , Ming Min , Jiang Yuan-Ze , Duan Hui-Zong , Yeh Hsien-Chi
Published: June 2018

Laser link acquisition is a key technology for inter-satellite laser ranging and laser communication. In this paper, we present an acquisition scheme based on the differential power sensing method with dual-way scanning, which will be used in the next-generation gravity measurement mission proposed in China, called Space Advanced Gravity Measurements (SAGM). In this scheme, the laser beams emitted from two satellites are power-modulated at different frequencies to enable the signals of the two beams to be measured distinguishably, and their corresponding pointing angles are determined by using the differential power sensing method. As the master laser beam and the slave laser beam are decoupled, the dual-way scanning method, in which the laser beams of both the master and the slave satellites scan uncertainty cones simultaneously and independently, can be used, instead of the commonly used single-way scanning method, in which the laser beam of one satellite scans and that of the other one stares. Therefore, the acquisition time is reduced significantly. Numerical simulation and experiments of the acquisition process are performed using the design parameters of the SAGM mission. The results show that the average acquisition time is less than 10 s for a scanning range of 1-mrad radius with a success rate of more than 99%.