bluuebunny/crossref_metadata_2025 huggingface dataset:
Plant-Derived Nanocellulose with Antibacterial Activity for Wound Healing Dressing
Authors: Oprică Gabriela Mădălina , Panaitescu Denis Mihaela , Lixandru Brînduşa Elena , Uşurelu Catalina Diana , Gabor Augusta Raluca , Nicolae Cristian-Andi , Fierascu Radu Claudiu , Frone Adriana Nicoleta
Published: November 2023

The medical sector is one of the biggest consumers of single-use materials, and while the insurance of sterile media is non-negotiable, the environmental aspect is a chronic problem. Nanocellulose (NC) is one of the safest and most promising materials that can be used in medical applications due to its valuable properties like biocompatibility and biodegradability, along with its good mechanical properties and high water uptake capacity. However, NC has no bactericidal activity, which is a critical need for the effective prevention of infections in chronic diabetic wound dressing applications. Therefore, in this work, a natural product, propolis extract (PE), was used as an antibacterial agent, in different amounts, together with NC to obtain sponge-like structures (NC/PE). The scanning electron microscope (SEM) images showed well-impregnated cellulose fibers and a more compact structure with the addition of PE. According to the thermogravimetric analysis (TGA), the samples containing PE underwent thermal degradation before the unmodified NC due to the presence of volatile compounds in the extract. However, the peak degradation temperature in the first derivative thermogravimetric curves was higher for all the sponges containing PE when compared to the unmodified NC. The antibacterial efficacy of the samples was tested against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, as well as on two clinically resistant isolates. The samples completely inhibited the development of Staphylococcus aureus, and Pseudomonas aeruginosa was partially inhibited, while Escherichia coli was resistant to the PE action. Considering the physical and biological properties along with the environmental and economic benefits, the development of an NC/PE wound dressing seems promising.
Pharmacokinetic Study of Islatravir and Etonogestrel Implants in Macaques
Authors: Daly Michele B. , Wong-Sam Andres , Li Linying , Krovi Archana , Gatto Gregory J. , Norton Chasity , Luecke Ellen H. , Mrotz Victoria , Forero Catalina , Cottrell Mackenzie L. , Schauer Amanda P. , Gary Joy , Nascimento-Seixas Josilene , Mitchell James , van der Straten Ariane , Heneine Walid , Garcίa-Lerma J. Gerardo , Dobard Charles W. , Johnson Leah M.
Published: November 2023

The prevention of HIV and unintended pregnancies is a public health priority. Multi-purpose prevention technologies capable of long-acting HIV and pregnancy prevention are desirable for women. Here, we utilized a preclinical macaque model to evaluate the pharmacokinetics of biodegradable ε-polycaprolactone implants delivering the antiretroviral islatravir (ISL) and the contraceptive etonogestrel (ENG). Three implants were tested: ISL-62 mg, ISL-98 mg, and ENG-33 mg. Animals received one or two ISL-eluting implants, with doses of 42, 66, or 108 µg of ISL/day with or without an additional ENG-33 mg implant (31 µg/day). Drug release increased linearly with dose with median [range] plasma ISL levels of 1.3 [1.0–2.5], 1.9 [1.2–6.3] and 2.8 [2.3–11.6], respectively. The ISL-62 and 98 mg implants demonstrated stable drug release over three months with ISL-triphosphate (ISL-TP) concentr54ations in PBMCs above levels predicted to be efficacious for PrEP. Similarly, ENG implants demonstrated sustained drug release with median [range] plasma ENG levels of 495 [229–1110] pg/mL, which suppressed progesterone within two weeks and showed no evidence of altering ISL pharmacokinetics. Two of the six ISL-98 mg implants broke during the study and induced implant-site reactions, whereas no reactions were observed with intact implants. We show that ISL and ENG biodegradable implants are safe and yield sufficient drug levels to achieve prevention targets. The evaluation of optimized implants with increased mechanical robustness is underway for improved durability and vaginal efficacy in a SHIV challenge model.
The Exploitation of pH-Responsive Eudragit-Coated Mesoporous Silica Nanostructures in the Repurposing of Terbinafine Hydrochloride for Targeted Colon Cancer Inhibition: Design Optimization, In Vitro Characterization, and Cytotoxicity Assessment
Authors: Alyami Mohammad H. , Musallam Abeer A. , Ibrahim Tarek M. , Mahdy Mahmoud A. , Elnahas Hanan M. , Aldeeb Reem A.
Published: November 2023

Targeted drug delivery is achieving great success in cancer therapy due to its potential to deliver drugs directly to the action site. Terbinafine hydrochloride (TER) is a broad-spectrum anti-fungal drug that has been found to have some potential anti-tumor effects in the treatment of colon cancer. We aimed here to design and develop pH-sensitive Eudragit (Eud)-coated mesoporous silica nanostructures (MSNs) to control drug release in response to changes in pH. The diffusion-supported loading (DiSupLo) technique was applied for loading TER into the MSNs. The formulation was optimized by a D-optimal design, which permits the concurrent assessment of the influence of drug/MSN%, coat concentration, and MSN type on the drug entrapment efficiency (EE) and its release performance. The optimal formula displayed a high EE of 96.49%, minimizing the release in pH 1.2 to 16.15% and maximizing the release in pH 7.4 to 78.09%. The cytotoxicity of the optimal formula on the colon cancer cells HT-29 was higher than it was with TER alone by 2.8-fold. Apoptosis in cancer cells exposed to the optimum formula was boosted as compared to what it was with the plain TER by 1.2-fold and it was more efficient in arresting cells during the G0/G1 and S stages of the cell cycle. Accordingly, the repurposing of TER utilizing Eud/MSNs is a promising technique for targeted colon cancer therapy.
Intradermal Delivery of Naked mRNA Vaccines via Iontophoresis
Authors: Hasan Mahadi , Khatun Anowara , Kogure Kentaro
Published: November 2023

Messenger RNA (mRNA) vaccines against infectious diseases and for anticancer immunotherapy have garnered considerable attention. Currently, mRNA vaccines encapsulated in lipid nanoparticles are administrated via intramuscular injection using a needle. However, such administration is associated with pain, needle phobia, and lack of patient compliance. Furthermore, side effects such as fever and anaphylaxis associated with the lipid nanoparticle components are also serious problems. Therefore, noninvasive, painless administration of mRNA vaccines that do not contain other problematic components is highly desirable. Antigen-presenting cells reside in the epidermis and dermis, making the skin an attractive vaccination site. Iontophoresis (ItP) uses weak electric current applied to the skin surface and offers a noninvasive permeation technology that enables intradermal delivery of hydrophilic and ionic substances. ItP-mediated intradermal delivery of biological macromolecules has also been studied. Herein, we review the literature on the use of ItP technology for intradermal delivery of naked mRNA vaccines which is expected to overcome the challenges associated with mRNA vaccination. In addition to the physical mechanism, we discuss novel biological mechanisms of iontophoresis, particularly ItP-mediated opening of the skin barriers and the intracellular uptake pathway, and how the combined mechanisms can allow for effective intradermal delivery of mRNA vaccines.
In-Line Aerosol Therapy via Nasal Cannula during Adult and Paediatric Normal, Obstructive, and Restrictive Breathing
Authors: Mac Giolla Eain Marc , MacLoughlin Ronan
Published: November 2023

High-flow nasal oxygen therapy is being increasingly adopted in intensive and home care settings. The concurrent delivery of aerosolised therapeutics allows for the targeted treatment of respiratory illnesses. This study examined in-line aerosol therapy via a nasal cannula to simulated adult and paediatric models with healthy, obstructive and restrictive lung types. The Aerogen Solo vibrating mesh nebuliser was used in combination with the InspiredTM O2FLO high-flow therapy system. Representative adult and paediatric head models were connected to a breathing simulator, which replicated several different states of lung health. The aerosol delivery was quantified at the tracheal level using UV-spectrophotometry. Testing was performed at a range of supplemental gas flow rates applicable to both models. Positive end-expiratory pressure was measured pre-, during and post-nebulisation. The increases in supplemental gas flow rates resulted in a decrease in aerosol delivery, irrespective of lung health. Large tidal volumes and extended inspiratory phases were associated with the greatest aerosol delivery. Gas flow to inspiratory flow ratios of 0.29–0.5 were found to be optimum for aerosol delivery. To enhance aerosol delivery to patients receiving high-flow nasal oxygen therapy, respiratory therapists should keep supplemental gas-flow rates below the inspiratory flow of the patient.
In Vitro Wound Healing Potential of a Fibroin Film Incorporating a Cannabidiol/2-Hydroxypropyl-β-cyclodextrin Complex
Authors: Klinsang Thamonphat , Charoensit Pensri , Phimnuan Preeyawass , Luangpraditkun Kunlathida , Ross Gareth M. , Viennet Céline , Ross Sukunya , Viyoch Jarupa
Published: November 2023

This study aimed to develop a film dressing prepared by incorporating a complex of cannabidiol and 2-hydroxypropyl-β-cyclodextrin (CBD/HP-β-CD) into a fibroin-based film and to investigate its wound healing capabilities. The fibroin from silkworm cocoons exhibited a total protein content of 96.34 ± 0.14% w/w and a molecular weight range of 25 to 245 kDa. Fourier-transform infrared spectroscopy (FTIR) revealed the presence of characteristic amide peaks (I, II, and III) in the isolated fibroin. The CBD/HP-β-CD complex, prepared with a molar ratio of 1:2 (CBD to HP-β-CD), had 81.5 ± 1.2% w/w CBD content, as determined by high-performance liquid chromatography (HPLC). X-ray diffraction (XRD) and FTIR analyses demonstrated successful encapsulation of CBD’s hydrophobic aromatic rings by HP-β-CD. Blending the fibroin solution with the CBD/HP-β-CD complex produced a transparent, slightly yellowish film. Mechanical testing revealed a tensile strength of 48.67 ± 2.57 MPa and a % elongation at a break of 1.71 ± 0.21%. XRD and FTIR analyses showed distinctive crystalline and chemical structures of the film. In subsequent in vitro experiments with normal human dermal fibroblasts, the film demonstrated potential for wound healing. An increase in cell division (G2/M phase) was observed compared to the fibroin film without the CBD/HP-β-CD complex. Additionally, fibroblasts treated with the film exhibited enhanced cell migration in a scratch assay and increased expression of vascular endothelial growth factor protein compared to the control group. Overall, these findings underscore the film’s potential for enhancing wound healing outcomes.
Photodynamic Eradication of Pseudomonas aeruginosa with Ru-Photosensitizers Encapsulated in Enzyme Degradable Nanocarriers
Authors: Kaur Kawaljit , Müller Max , Müller Mareike , Schönherr Holger
Published: November 2023

The development of new approaches for the treatment of the increasingly antibiotic-resistant pathogen Pseudomonas aeruginosa was targeted by enhancing the effect of local antimicrobial photodynamic therapy (aPDT) using poly(ethylene glycol)-block-poly(lactic acid) (PEG114-block-PLAx) nanocarriers that were loaded with a ruthenium-based photosensitizer (PS). The action of tris(1,10-phenanthroline) ruthenium (II) bis(hexafluorophosphate) (RuPhen3) encapsulated in PEG114-block-PLAx micelles and vesicles was shown to result in an appreciable aPDT inactivation efficiency against planktonic Pseudomonas aeruginosa. In particular, the encapsulation of the PS, its release, and the efficiency of singlet oxygen (1O2) generation upon irradiation with blue light were studied spectroscopically. The antimicrobial effect was analyzed with two strains of Pseudomonas aeruginosa. Compared with PS-loaded micelles, formulations of the PS-loaded vesicles showed 10 times enhanced activity with a strong photodynamic inactivation effect of at least a 4.7 log reduction against both a Pseudomonas aeruginosa lab strain and a clinical isolate collected from the lung of a cystic fibrosis (CF) patient. This work lays the foundation for the targeted eradication of Pseudomonas aeruginosa using aPDT in various medical application areas.
Improving Bioaccessibility and Bioavailability of Isoflavone Aglycones from Chickpeas by Germination and Forming β-Cyclodextrin Inclusion Complexes
Authors: He Yuanfan , Xiang Jiani , Chen Jie , Fang Sheng , Guo Zili , Liang Xianrui
Published: November 2023

Chickpea isoflavones have diverse pharmacological activities but with low water solubility and bioavailability. In this work, the isoflavone content in chickpeas was first increased by germination, and then the bioaccessibility and bioavailability of isoflavones in chickpea sprout extracts (CSE) were enhanced using β-cyclodextrin (β-CD) inclusion techniques. Firstly, the total content of isoflavones was increased by 182 times through sprouting, and isoflavones were presented mostly in the germ and radicle. Then, the chickpea sprout extract/β-cyclodextrin (CSE/β-CD) inclusion complex was prepared and characterized. The in vitro test showed that the cumulative release of two isoflavones, formononetin (FMN) and biochanin A (BCA), in the CSE/β-CD was significantly increased in a simulated digestive fluid. The in vivo rat pharmacokinetics demonstrated that the inclusion of FMN and BCA by β-CD effectively increased their bioavailability in rat plasma and tissues, especially in the liver. The study provides a feasible strategy for improving the bioavailability of isoflavones from chickpeas and is also beneficial to the utilization of other legume resources.
Study of the Molecular Architectures of 2-(4-Chlorophenyl)-5-(pyrrolidin-1-yl)-2H-1,2,3-triazole-4-carboxylic Acid Using Their Vibrational Spectra, Quantum Chemical Calculations and Molecular Docking with MMP-2 Receptor
Authors: Palafox Mauricio Alcolea , Belskaya Nataliya P. , Kostova Irena P.
Published: November 2023

1,2,3-triazole skeleton is a valuable building block for the discovery of new promising anticancer agents. In the present work, the molecular structure of the synthesized anticancer drug 2-(4-chlorophenyl)-5-(pyrrolidin-1-yl)-2H-1,2,3-triazole-4-carboxylic acid (1b) and its anionic form (2b) was characterized by means of the B3LYP, M06-2X and MP2 quantum chemical methods, optimizing their monomer, cyclic dimer and stacking forms using the Gaussian16 program package. The molecular structure was found to be slightly out of plane. The good agreement between the IR and Raman bands experimentally observed in the solid state with those calculated theoretically confirms the synthesized structures. All of the bands were accurately assigned according to functional calculations (DFT) in the monomer and dimer forms, together with the polynomic scaling equation procedure (PSE). Therefore, the effect of the substituents on the triazole ring and the effect of the chlorine atom on the molecular structure and on the vibrational spectra were evaluated through comparison with its non-substituted form. Through molecular docking calculations, it was evaluated as to how molecule 1b interacts with few amino acids of the MMP-2 metalloproteinase receptor, using Sybyl-X 2.0 software. Thus, the relevance of triazole scaffolds in established hydrogen bond-type interactions was demonstrated.
Modular Nanotransporters Delivering Biologically Active Molecules to the Surface of Mitochondria
Authors: Khramtsov Yuri V. , Ulasov Alexey V. , Slastnikova Tatiana A. , Rosenkranz Andrey A. , Lupanova Tatiana N. , Georgiev Georgii P. , Sobolev Alexander S.
Published: November 2023

Treatment of various diseases, in particular cancer, usually requires the targeting of biologically active molecules at a selected subcellular compartment. We modified our previously developed modular nanotransporters (MNTs) for targeting mitochondria. The new MNTs are capable of binding to the protein predominantly localized on the outer mitochondrial membrane, Keap1. These MNTs possessing antiKeap1 monobody co-localize with mitochondria upon addition to the cells. They efficiently interact with Keap1 both in solution and within living cells. A conjugate of the MNT with a photosensitizer, chlorin e6, demonstrated significantly higher photocytotoxicity than chlorin e6 alone. We assume that MNTs of this kind can improve efficiency of therapeutic photosensitizers and radionuclides emitting short-range particles.
Pyrolysis Kinetics Analysis and Prediction for Carbon Fiber-Reinforced Epoxy Composites
Authors: Xiao Pei , Zhang Jingyi , Li Han , Mou Haolei , Feng Zhenyu , Xie Jiang
Published: November 2023

Carbon fiber-reinforced epoxy resin composites have poor high temperature resistance and are prone to thermal damage during service in the aerospace field. The purpose of this study was to evaluate the thermal decomposition (pyrolysis) characteristics of carbon fiber-reinforced epoxy composites and reasonably predict their thermal decomposition under arbitrary temperature conditions. The kinetic analysis was conducted on the thermal decomposition of carbon fiber-reinforced epoxy resin composites (USN15000/9A16/RC33, supplied by Weihai GuangWei Composites Co., Ltd. Weihai City, Shandong Province, China) under a nitrogen environment, and an improved model of pyrolysis prediction suitable for the arbitrary temperature program was developed in this work. The results showed that the carbon fiber-reinforced epoxy composites begin to degrade at about 500 K, and the peak value of the weight loss rate at the respective heating rate appears in the range of 650 K to 750 K. A single-step reaction can characterize the thermal decomposition of carbon fiber-reinforced epoxy composites in a nitrogen atmosphere, and a wide variety of isoconversional approaches can be used for the calculation of the kinetic parameters. The proposed model of pyrolysis prediction can avoid numerous limitations of temperature integration, and it shows good prediction accuracy by reducing the temperature rise between sampling points. This study provides a reference for the kinetic analysis and pyrolysis prediction of carbon fiber-reinforced epoxy composites.
Effect of Glycerol Concentrations on the Characteristics of Cellulose Films from Cattail (Typha angustifolia L.) Flowers
Authors: Khotsaeng Nuanchai , Simchuer Wilaiwan , Imsombut Thanonchat , Srihanam Prasong
Published: November 2023

Plastic waste has become a big problem for the environment globally. Biodegradable polymers are a potential replacement for plastics that can have a positive outcome both environmentally and economically. In this work, we used acid hydrolysis and alkaline treatment to extract cellulose fibers from cattails. The obtained cellulose was used as a substrate for the fabrication of cellulose film using a casting technique on plastic plates. Different concentrations of the plasticizer, glycerol, were used to prepare films for comparison, and its effects on the film’s characteristics were observed. The morphology, chemical structure, and thermal stability of the cattail cellulose (CTC) films were studied using techniques such as scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and thermogravimetric analysis (TGA), respectively. Measurements of transparency, moisture content (MC), water solubility (MS), and water contact angle (WCA) were also performed. Introducing glycerol into the films increased the transparency, MC, and WS values, as well as the gap width between film textures. However, it resulted in a decrease in the WCA of the films, showing that the hydrophilicity of the films is increased by the addition of glycerol. The interaction between the functional groups of cellulose and glycerol was established from the ATR-FTIR and XRD data. The obtained results indicated that glycerol affected the thermal stability and the degree of crystallinity of the produced films. Accordingly, the hydrophilicity of the cellulose film was increased by increasing the glycerol content; therefore, cattail cellulose films can be used as a biodegradable alternative to plastic in the future.
One-Dimensional Nickel Molybdate Nanostructures with Enhanced Supercapacitor Performance
Authors: Sun Baodong , Wang Shaomin , Zhang Mingyi
Published: November 2023

One-dimensional NiMoO4 nanofibers were successfully prepared by electrospinning and high-temperature calcination. The supercapacitor performance tests were conducted on the prepared materials in a three-electrode system, and it was found that the calcination temperature during the preparation of the fibers seriously affects the final morphology and electrochemical performance of the obtained samples. The sample with a calcination temperature of 500 °C has better performance, its specific capacitance can reach 1947 F g−1, and the retention rate is 82.35% after 3000 cycles of constant current charging–discharging. The improvement of electrochemical performance is primarily on account of the unique one-dimensional nanostructure of the material, which can both enhance the charge transfer efficiency and effectively increase the speed of electrolyte ion diffusion.
Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds
Authors: Capanema Nádia S. V. , Mansur Alexandra A. P. , Carvalho Sandhra M. , Martins Talita , Gonçalves Maysa S. , Andrade Rafaella S. , Dorneles Elaine M. S. , Lima Letícia C. D. , de Alvarenga Érika L. F. C. , da Fonseca Emanuel V. B. , Sá Marcos Augusto de , Lage Andrey P. , Lobato Zelia I. P. , Mansur Herman S.
Published: November 2023

Diabetic foot ulcers (DFUs) are considered one of the most severe chronic complications of diabetes and can lead to amputation in severe cases. In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer matrices with embedded metal nanoparticles can inhibit microorganism growth and promote wound healing, although the current clinical treatments for diabetic chronic wounds remain unsatisfactory. In this view, this research reports the synthesis and characterization of innovative hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) chemically crosslinked by citric acid (CA) functionalized with silver nanoparticles (AgNPs) generated in situ using an eco-friendly aqueous process. The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections. Hence, it can be envisioned that, with further research and development, these polymer-based hybrid nanoplatforms hold great potential as an important tool for creating a new generation of smart dressings for treating chronic diabetic wounds and opportunistic bacterial infections.
Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules
Authors: Li Xu , Jin Yan , Zhu Nansong , Jin Long Yi
Published: November 2023

Supramolecular chemistry enables the manipulation of functional components on a molecular scale, facilitating a “bottom-up” approach to govern the sizes and structures of supramolecular materials. Using dynamic non-covalent interactions, supramolecular polymers can create materials with reversible and degradable characteristics and the abilities to self-heal and respond to external stimuli. Pillar[n]arene represents a novel class of macrocyclic hosts, emerging after cyclodextrins, crown ethers, calixarenes, and cucurbiturils. Its significance lies in its distinctive structure, comparing an electron-rich cavity and two finely adjustable rims, which has sparked considerable interest. Furthermore, the straightforward synthesis, uncomplicated functionalization, and remarkable properties of pillar[n]arene based on supramolecular interactions make it an excellent candidate for material construction, particularly in generating interpenetrating supramolecular polymers. Polymers resulting from supramolecular interactions involving pillar[n]arene find potential in various applications, including fluorescence sensors, substance adsorption and separation, catalysis, light-harvesting systems, artificial nanochannels, and drug delivery. In this context, we provide an overview of these recent frontier research fields in the use of pillar[n]arene-based supramolecular polymers, which serves as a source of inspiration for the creation of innovative functional polymer materials derived from pillar[n]arene derivatives.
Highly Self-Healable Polymeric Coating Materials Based on Charge Transfer Complex Interactions with Outstanding Weatherability
Authors: Hong Pyong Hwa , Moon Gyeongmin , Kim Jinsil , Choi Kiwon , Ko Min Jae , Yoon Ho Gyu , Hong Sung Woo
Published: November 2023

In this study, we prepare highly self-healable polymeric coating materials using charge transfer complex (CTC) interactions. The resulting coating materials demonstrate outstanding thermal stability (1 wt% loss thermal decomposition temperature at 420 °C), rapid self-healing kinetics (in 5 min), and high self-healing efficiency (over 99%), which is facilitated by CTC-induced multiple interactions between the polymeric chains. In addition, these materials exhibit excellent optical properties, including transmittance over 91% and yellow index (YI) below 2, and show enhanced weatherability with a ΔYI value below 0.5 after exposure to UV light for 72 h. Furthermore, the self-healable coating materials developed in this study show outstanding mechanical properties by overcoming the limitations of conventional self-healing materials.
Hydrothermal Ammonia Carbonization of Rice Straw for Hydrochar to Separate Cd(II) and Zn(II) Ions from Aqueous Solution
Authors: Wang Jiarui , Wei Xiaocheng , Kong Hao , Zheng Xiangqun , Guo Haixin
Published: November 2023

Hydrochar is considered to be a good adsorbent for the separation of metal ions from aqueous solutions. However, the yield of hydrochar from raw straw is generally low, because the hydrothermal carbonization occurs via dehydration, polymerization, and carbonization. In this work, various hydrochar samples were prepared from rice straw with nitrogen and phosphorus salt; moreover, toilet sewage was used instead of nitrogen, and phosphorus salt and water were used to promote the polymerization and carbonization process. The modified carbon was characterized using XRD, XPS, SEM, and FTIR, and the adsorption capacity was investigated. A significant increase in hydrochar yield was observed when toilet sewage was used as the solvent in the hydrothermal carbonization process. The adsorption capacity of N/P-doped rice straw hydrochar for Cd2+ and Zn2+ metal ions was 1.1–1.4 times higher than that those using the rice straw hydrochar. The Langmuir models and pseudo-second-order models described the metal adsorption processes in both the single and binary-metal systems well. The characterization results showed the contribution of the surface complexation, the electrostatic interaction, the hydrogen bond, and the ion exchange to the extraction of Cd2+ and Zn2+ using N/P-doped rice straw hydrochar.
Characterization of the Polyetheretherketone Weldment Fabricated via Rotary Friction Welding
Authors: Kuo Chil-Chyuan , Liang Hua-Xhin , Huang Song-Hua
Published: November 2023

Polyether ether ketone (PEEK) is frequently employed in biomedical engineering due to its biocompatibility. Traditionally, PEEK manufacturing methods involve injection molding, compression molding, additive manufacturing, or incremental sheet forming. Few studies have focused on rotational friction welding (RFW) with PEEK plastics. Based on years of RFW practical experience, the mechanical properties of the weldment are related to the burn-off length. However, few studies have focused on this issue. Therefore, the main objective of this study is to assess the effects of burn-off length on the mechanical properties of the welded parts using PEEK polymer rods. The welding pressure can be determined by the rotational speed according to the proposed prediction equation. The burn-off length of 1.6 mm seems to be an optimal burn-off length for RFW. For the rotational speed of 1000 rpm, the average bending strength of the welded parts was increased from 108 MPa to 160 Mpa, when the burn-off length was increased from 1 mm to 1.6 mm and the cycle time of RFW was reduced from 80 s to 76 s. A saving in the cycle time of RFW of about 5% can be obtained. The bending strength of the welded part using laser welding is lower than that using RFW, because only the peripheral material of the PEEK cylinder was melted by the laser.
Pierre Claverie: Weakening the Truth—A Catholic Post-Conciliar Model of Understanding Religious Plurality
Authors: Crișan Alexandru-Marius
Published: November 2023

Born into a pieds-noir family in Algeria in the first part of the 20th century, Pierre Claverie (1938–1996) realizes that he lived in a colonial bubble, completely ignoring the Algerian and Muslim realities. This “prise de conscience” will constitute the beginning of a deep mystical experience, a true process of “spiritual enlightenment” through which Claverie will try to re-establish himself in the lost meeting of his youth when he used to live in his “Western and Catholic bubble”. His theological path will also be an institutional one: he will become a Dominican monk and Catholic bishop of Orano. Inevitably, his desire to spiritually encounter the Algerian reality in its Muslim identity will make Pierre Claverie reflect on the tension present in the paradox of the concept of religious truth (absolutely unique and/or multiple?). His reflection on the uniqueness/pluralism of religious truth represents a model of post-conciliar theological understanding that is worth examining and that supports a very current approach in today’s religious and social world: understanding/accepting the truth of the other without the impression of betraying one’s own truth. This study aims to deepen the mystical theological reflection of Bishop Pierre Claverie, considered a martyr in the Catholic Church, with regards to the concept of religious truth. It also to tries to understand how this reflection fits into the Catholic theological line inaugurated by the Second Vatican Council (1962–1965).
The Value of Old Age in the Teaching of Pope Francis
Authors: Brzeziński Mirosław
Published: November 2023

The demographic changes taking place before our eyes regarding the structure of our society show that the proportion of older people is increasing quite rapidly. Very often these are people who want to be involved in the life of the family, society, and the Church, although their presence and involvement is not always viewed positively by the younger generations. On the other hand, the time of old age is a difficult time with many challenges, such as loss of health, and consequently the elderly need the support of the younger generations. This reality is also recognised by Pope Francis, and it could be said that the problem of the elderly is close to his heart. An expression of the importance and value of older people is, for example, his frequent meetings with older people, the establishment of a World Day for Grandparents and Older Persons, or the series of catechesis on old age and the value of this time in people’s lives delivered in 2022. Taking into account these aspects of social change and based on the totality of Pope Francis’ teachings addressed to the elderly, we wish to highlight distinctive elements emphasising the value of the elderly in the life of the family, society, and the Church. Starting from the presentation of the family as the best and natural environment for living during the time of old age, these teachings highlight older people as “guardians” of roots and values, the importance of intergenerational dialogue and a type of “covenant of generations”, and the importance of older people in the life of the Church. An important element of Francis’ teachings on old age is to identify this period as a “time of grace”, a time of looking at life from the perspective of the years and trying to take stock of it, and a time of thanksgiving. All of this is done to emphasise the importance and value of the time of old age and to see and appreciate their presence in the life of the family, society, and the Church.
“Good Militias” for Trump: Race, Religion, and Legitimacy in the Modern Militia Movement
Authors: Berry Damon T.
Published: November 2023

Since the mid-1990s, the popular perception of the militia movement in the United States has associated it with racism and far-right expressions of Christianity. There are good reasons for this assessment, though the movement is more complex than such generalizations suggest. In this article, I describe how Oath Keepers mobilized the image of a “good militia” seeking broader legitimacy and how their efforts have often been damaged by troubling and even criminal elements in their organization, which included militant efforts to keep Trump in power by attempting to subvert the 2020 election. I further argue that public revelations of the group’s racialized discourses and activities, allegations of domestic abuse against its founder, and the recent convictions related to 6 January, including seditious conspiracy, further challenge this effort at legitimization and have thrown the organization into disarray. Moreover, I argue though broader legitimacy may be now out of reach for this fragmented and isolated organization, they may yet find legitimacy among Christian nationalists who have come to conclude that political violence is potentially necessary to save America.
Mystic on a Tilting Stage: Julian of Norwich’s Performance of English Visionary Devotion
Authors: Perry Elizabeth F.
Published: November 2023

Julian of Norwich’s performance within her longer Revelations of Divine Love involves layers of authorizing and devotional steps that frame it as a gift for her community. She presents herself not as an author, but as a revelator, in step with John’s acts of unveiling his visions and dialogue with the divine in the Biblical Revelations. Examining Julian’s act of presenting her visions in writing demonstrates how her daring yet insistently orthodox visions handle issues of spiritual authority and individual faith made urgent by the rise of Lollardy. My work with Julian’s Revelations is the foundation for a wider argument about the interchange between vernacular mysticism and public devotion through their use of affective piety and the performance of spiritual dialogue. In this article, I examine Julian of Norwich’s Revelation of Divine Love to determine how it works as contemplative drama. I also look at The Mirror of the Blessed Life of Christ and The Cloud of Unknowing to set up Julian’s performance of contemplative devotion and the potential pitfalls of a pious English readership. Julian’s revelations demonstrate where interior contemplation is transformed into collective acts of devotion.
Is God a Substance? Avicenna on Essence, Being, and the Categories
Authors: Taylor Nathaniel B.
Published: November 2023

Avicenna scholars unanimously agree that Avicenna takes the position that God is not classifiable according to the Aristotelian scheme of the ten categories. However, Avicenna scholars are in little agreement about precisely why God evades categorial classification. Scholars report numerous and, at times, mutually inconsistent arguments purportedly made by Avicenna. In this study, I argue that Avicenna has only one argument as to why God is not in the category of substance—the Essence-Being Distinction Argument—and that he makes this argument consistently throughout his major philosophical encyclopediae. Having clarified this argument, two consequences follow. First, we can study this argument to learn not only about God in Avicenna’s philosophical theology but also about the nature and structure of the categories in Avicenna’s metaphysics. I argue that Avicenna’s Essence-Being Distinction Argument reveals a route by which one may arrive at a real distinction between essence and being from a philosophical, rather than a theological premise. Second, Avicenna’s Essence-Being Distinction Argument, along with the prevalence and consistency thereof, suggests that God has an essence for Avicenna and that texts, wherein Avicenna denies that God has an essence, are exceptional and should not govern our broader interpretation of Avicenna’s philosophical theology.
Learning to Adapt Adversarial Perturbation Consistency for Domain Adaptive Semantic Segmentation of Remote Sensing Images
Authors: Xi Zhihao , Meng Yu , Chen Jingbo , Deng Yupeng , Liu Diyou , Kong Yunlong , Yue Anzhi
Published: November 2023

Semantic segmentation techniques for remote sensing images (RSIs) have been widely developed and applied. However, most segmentation methods depend on sufficiently annotated data for specific scenarios. When a large change occurs in the target scenes, model performance drops significantly. Therefore, unsupervised domain adaptation (UDA) for semantic segmentation is proposed to alleviate the reliance on expensive per-pixel densely labeled data. In this paper, two key issues of existing domain adaptive (DA) methods are considered: (1) the factors that cause data distribution shifts in RSIs may be complex and diverse, and existing DA approaches cannot adaptively optimize for different domain discrepancy scenarios; (2) domain-invariant feature alignment, based on adversarial training (AT), is prone to excessive feature perturbation, leading to over robust models. To address these issues, we propose an AdvCDA method that guides the model to adapt adversarial perturbation consistency. We combine consistency regularization to consider interdomain feature alignment as perturbation information in the feature space, and thus propose a joint AT and self-training (ST) DA method to further promote the generalization performance of the model. Additionally, we propose a confidence estimation mechanism that determines network stream training weights so that the model can adaptively adjust the optimization direction. Extensive experiments have been conducted on Potsdam, Vaihingen, and LoveDA remote sensing datasets, and the results demonstrate that the proposed method can significantly improve the UDA performance in various cross-domain scenarios.
FCOSR: A Simple Anchor-Free Rotated Detector for Aerial Object Detection
Authors: Li Zhonghua , Hou Biao , Wu Zitong , Ren Bo , Yang Chen
Published: November 2023

Although existing anchor-based oriented object detection methods have achieved remarkable results, they require manual preset boxes, which introduce additional hyper-parameters and calculations. These methods often use more complex architectures for better performance, which makes them difficult to deploy on computationally constrained embedded platforms, such as satellites and unmanned aerial vehicles. We aim to design a high-performance algorithm that is simple, fast, and easy to deploy for aerial image detection. In this article, we propose a one-stage anchor-free rotated object detector, FCOSR, that can be deployed on most platforms and uses our well-defined label assignment strategy for the features of the aerial image objects. We use the ellipse center sampling method to define a suitable sampling region for an oriented bounding box (OBB). The fuzzy sample assignment strategy provides reasonable labels for overlapping objects. To solve the problem of insufficient sampling, we designed a multi-level sampling module. These strategies allocate more appropriate labels to training samples. Our algorithm achieves an mean average precision (mAP) of 79.25, 75.41, and 90.13 on the DOTA-v1.0, DOTA-v1.5, and HRSC2016 datasets, respectively. FCOSR demonstrates a performance superior to that of other methods in single-scale evaluation, where the small model achieves an mAP of 74.05 at a speed of 23.7 FPS on an RTX 2080-Ti GPU. When we convert the lightweight FCOSR model to the TensorRT format, it achieves an mAP of 73.93 on DOTA-v1.0 at a speed of 17.76 FPS on a Jetson AGX Xavier device with a single scale.
Preliminary Estimations of Mars Atmospheric and Ionospheric Profiles from Tianwen-1 Radio Occultation One-Way, Two-Way, and Three-Way Observations
Authors: Liu Min , Chen Lue , Jian Nianchuan , Guo Peng , Kong Jing , Wang Mei , Han Qianqian , Ping Jinsong , Wu Mengjie
Published: November 2023

The radio occultation method, one of the methods used to provide planetary atmospheric profiles with high vertical resolution, was applied to China’s first Mars mission, Tianwen-1. We carried out observations based on the Chinese Deep Space Network, and one-way, two-way, and three-way modes were used for Doppler observations from the Tianwen-1 spacecraft. We successfully obtained effective observations from Tianwen-1 on 22 and 25 March 2022. An inversion system developed for Tianwen-1 radio occultation observations enabled the derivation of neutral atmospheric density, pressure, temperature, and electron density profiles of Mars. Utilizing one-way tracking data, Martian ionospheric electron density profiles were retrieved at latitudes between 68.7 and 70.7 degrees (N). However, the presence of strong random walk noise in one-way tracking data led to poor inversion results. Meanwhile, Martian ionospheric electron density and neutral atmosphere profiles were extracted from two-way and three-way tracking data at latitudes between 55.1 and 57.0 degrees (S) on 22 March and at latitudes between 62.8 and 63.4 degrees (S) on 25 March. Importantly, our inversion results from Tianwen-1 maintained consistency with results from the Mars Express and the Chapman theory (mainly in the M2 layer). Through two days’ observation experiments, we established and verified the occultation solution system and prepared for the follow-up occultation plans.
UAVs and 3D City Modeling to Aid Urban Planning and Historic Preservation: A Systematic Review
Authors: Hu Dingkun , Minner Jennifer
Published: November 2023

Drone imagery has the potential to enrich urban planning and historic preservation, especially where it converges with the growing creation and use of 3D models in the context of cities and metro regions. Nevertheless, the widespread adoption of drones in these fields faces limitations, and there is a shortage of research addressing this issue. Therefore, we have conducted a systematic literature review of articles published between 2002 and 2022 drawing from reputable academic repositories, including Science Direct, Web of Science, and China National Knowledge Infrastructure (CNKI), to identify current gaps in the existing research on the application of UAVs to the creation of 3D models in the contexts of urban planning and historic preservation. Our findings indicate five research shortcomings for 3D city modeling: limited participation of planning experts, research focus imbalance, lack of usage for special scenarios, lack of integration with smart city planning, and limited interdisciplinary collaboration. In addition, this study acknowledges current limitations around UAV applications and discusses possible countermeasures along with future prospects.
Optimizing Water Level Management Strategies to Strengthen Reservoir Support for Bird’s Migration Network
Authors: Yi Kunpeng , Meng Fanjuan , Gu Dehai , Miao Qingyuan
Published: November 2023

Migratory waterbirds depend on a complex network of wetlands globally for their life cycles. However, habitat loss and degradation pose risks to these networks’ sustainability, potentially impacting wetland habitat availability. This study investigates the impact of water level changes in Beijing’s Miyun Reservoir on white-naped cranes’ (Antigone vipio) habitat use. We utilized satellite imagery from 2000–2021 and monthly data from 2018–2023 to observe changes in the reservoir’s water and land areas. Additionally, the study tracked 32 cranes using GSM-GPS loggers, yielding insights into their movement patterns and habitat preferences. Our findings emphasize the significant influence of reservoir water levels on habitat availability for these cranes. Notably, our results indicate that the decrease in suitable migratory bird habitats in the reservoir is primarily attributed to high-water level management strategies. This study highlights the necessity for balanced management of aquatic and terrestrial areas in reservoir ecosystems to preserve migratory waterbird habitats.
Bridging the Gap: Analyzing the Relationship between Environmental Justice Awareness on Twitter and Socio-Environmental Factors Using Remote Sensing and Big Data
Authors: Knoble Charles , Yu Danlin
Published: November 2023

Mounting awareness of the discriminatory distribution of environmental factors has increasingly placed environmental justice at the forefront of discussions on sustainable development, but responses to these disparities are often too little, too late. Remote sensing has emerged as a potential solution to this problem, capitalizing on the ability to capture high-resolution, spatially explicit data in near-real time. However, a conventional reliance on physical measurements and surface-level analyses risks overlooking the experiences and perceptions of affected communities. It is against this backdrop that the potential integration of remote sensing imagery and socially sensed big data such as social media data assumes a novel and promising role. This study aims to discern the feasibility, opportunities, and implications of integrating the spatial insights provided by remote sensing with the experiential narratives shared on social media platforms, bridging the gap between objective environmental data and community-driven perspectives. We explore this subject in two ways, analyzing the geographic relationship between environmental justice Tweets and environmental justice factors, and reviewing Tweets produced during an extensive wildfire. Remote sensing indexes for green and blue space were reviewed and tested, selecting the measures of best fit to act as independent variables alongside traditional environmental justice factors in the broader analysis. Results from regression models indicate a negative relationship between the number of Tweets utilizing environmental justice relevant terms and the presence of ecosystem services as captured by an NDMI, suggesting a broad awareness of injustice and a relationship between remote sensing and social media. However, there is simultaneously a negative relationship between socially vulnerable populations and Tweets with environmental justice words. This suggests that generally, there is discussion on Twitter about injustice when resources are not present, but the voices of vulnerable populations are often less visible, either as a result of urban bias or a lack of concern for injustices due to habitual ignorance. Our study demonstrates the potential for integrating remote sensing imagery and social sensing data to play a substantial role in detecting injustices and corroborating data collected through community science initiatives.