bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychotherapeutic Consultation Services in the Workplace: A Longitudinal Analysis of Treatments and Sick Leave Using Health Insurance Data
Authors: Gantner Melanie , Jarzcok Marc Nicolas , Schneider Jürgen , Brandner Stefan , Gündel Harald , von Wietersheim Jörn
Published: March 2022

Background

Psychotherapeutic consultation services in the workplace (PSIW) have been developed to provide collaborative mental health care for employees. The aim of this study was to analyze participant characteristics, the role of PSIW in treatment courses, and the development of sick leave before and after PSIW start.

Methods

Routine data from PSIW and health insurance of 155 participants were analyzed descriptively and by means of a multilevel negative binomial regression.

Results

Eighty-four percent of users were male, and 72% were diagnosed with a mental disorder. The number of PSIW consultations varied from 1 to 13 (mean = 4). For 34% of participants, PSIW sessions were sufficient, 33% received a recommendation for outpatient psychotherapy, and 20% for inpatient mental health treatment. While recommendations for inpatient treatment displayed a high adherence rate (74%), recommendations for outpatient treatment were followed by 37%. Compared with the period of a half-year before PSIW, sick-leave days were reduced from the period of the second half-year after PSIW start and in the subsequent observed half-year periods. Trajectories of sick leave by subgroups showed differences.

Conclusions

PSIW is a flexible care offer, and results indicate a possible effect of PSIW on sick leave. In future studies, control group designs and inclusion of further variables are needed.
Gaming Disorder Symptom Questionnaire: The Development and Validation of a Screening Tool for ICD-11 Gaming Disorder in Adolescents
Authors: Zhang Lina , Luo Tao , Hao Wei , Cao Yuanyuan , Yuan Ming , Liao Yanhui
Published: March 2022

Background

Gaming disorder (GD) has been recognized as an official diagnostic entity in the latest revision of the International Classification of Diseases (ICD-11). However, the majority of previous studies used different instruments, which are not fully consistent with the concept of GD in ICD-11. The development of a screening assessment instrument based on ICD-11 for this new disease entity is very urgent and important.

Methods

The ICD-11 Gaming Disorder Symptom Questionnaire (GDSQ), based on the ICD-11 diagnostic guidelines for GD, was developed by a team of GD experts. A total of 7,790 adolescents were included in this study. Criterion validity was assessed by GDSQ, Video Gaming Dependency Scale (VGDS), weekly game playing time, weekly game video viewing time, and monthly money spent on games. Item structure was measured by factorial analysis. Discrimination between GD and non-GD was examined based on the receiver characteristic curve (ROC).

Results

The GDSQ was very well described by three symptoms of GD (i.e., impaired control, increasing priority to gaming, and continued use despite the occurrence of negative consequences). The internal consistency was excellent (Cronbach's α = 0.964) with good criterion validity and good discriminatory power. The optimal cutoff point for determining the profile of gamers was found to be ≥62 points. The GDSQ revealed that the prevalence of GD was 2.27% in this adolescent sample.

Conclusion

The ICD-11–based GDSQ is a successfully validated measurement scale for GD among adolescents. This study provides a new tool (GDSQ) for us to effectively identify individuals with risk of GD in medical and non-medical settings.
Aquaporin-4, Connexin-30, and Connexin-43 as Biomarkers for Decreased Objective Sleep Quality and/or Cognition Dysfunction in Patients With Chronic Insomnia Disorder
Authors: Yang Shuai , Kong Xiao-Yi , Hu Ting , Ge Yi-Jun , Li Xue-Yan , Chen Jun-Tao , He Shuo , Zhang Ping , Chen Gui-Hai
Published: March 2022

Objectives

To examine serum concentrations of aquaporin-4 (AQP4), connexin-30 (CX30), connexin-43 (CX43), and their correlations with cognitive function in the patients with chronic insomnia disorder (CID).

Methods

We enrolled 76 subjects with CID and 32 healthy controls (HCs). Serum levels of AQP4, CX30, and CX43 were measured by enzyme-linked immunosorbent assays. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and polysomnography, and mood was evaluated with 17-item Hamilton Depression Rating Scale and 14-item Hamilton Anxiety Rating Scale. Cognitive function was evaluated by the Chinese-Beijing Version of Montreal Cognitive Assessment (MoCA-C) and Nine Box Maze Test.

Results

The serum levels of AQP4, CX43, and CX30 were significantly reduced in the CID group compared to the HCs. Partial correlation analysis showed that the biomarkers showed no significant correlations with PSQI score, AHI, ODI and TS90, but AQP4, CX43, and CX30 were positively associated with the percentage and total time of slow wave sleep in the CID group. Serum concentrations of AQP4 and CX30 were positively associated with MoCA-C score in the CID group, and AQP4 level negatively correlated with spatial working memory errors.

Conclusions

Subjects with CID patients have decreased serum levels of AQP4, CX30, and CX43 indicating astrocyte dysfunction, which could be related to poor objective sleep quality and/or cognition dysfunction.
Quality of Life in Internet Use Disorder Patients With and Without Comorbid Mental Disorders
Authors: Dieris-Hirche Jan , te Wildt Bert Theodor , Pape Magdalena , Bottel Laura , Steinbüchel Toni , Kessler Henrik , Herpertz Stephan
Published: March 2022

Introduction

Evidence from clinical studies on quality of life (QoL) in patients suffering from internet use disorders (IUD) is still limited. Furthermore, the impact of additional mental comorbidities on QoL in IUD patients has rarely been investigated yet.

Materials and Methods

In a cross-sectional clinical study 149 male subjects were analyzed for the presence and severity of an IUD as well as other mental disorders by experienced clinicians. The sample consisted of 60 IUD patients with and without comorbid mental disorders, 34 non-IUD patients with other mental disorders, and 55 healthy participants. Standardized clinical interviews (M.I.N.I. 6.0.0) and questionnaires on IUD symptom severity (s-IAT), QoL (WHOQOL-BREF), depression and anxiety symptoms (BDI-II and BAI), and general psychological symptoms (BSI) were used.

Results

Internet use disorder patients showed significantly reduced QoL compared to healthy controls (Cohen’s d = 1.64–1.97). Furthermore, IUD patients suffering from comorbid mental disorders showed significantly decreased levels of physical, social, and environmental QoL compared to IUD patients without any comorbidity (p < 0.05–0.001). Multiple linear regression analyses revealed that low levels of psychological, social and environmental QoL were mainly predicted by symptoms of depression. IUD factors were only significant predictors for the social and physical QoL.

Discussion

Internet use disorder patients with comorbid mental disorder reported the lowest QoL. Depression symptom severity was the most significant predictor of low QoL in IUD. Strategies to reduce depressive symptoms should therefore be considered in IUD treatment to increase patients’ QoL.
Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated
Authors: Nichols David E.
Published: March 2022

At first glance, it appears there is little difference between the molecular structures of methylenedioxymethamphetamine (MDMA), which has an N-methyl attached to its amino group, and methylenedioxyamphetamine (MDA), a primary amine that is recognized to have hallucinogenic activity. It is known from studies with other hallucinogenic amphetamines that N-methylation of hallucinogenic amphetamines attenuates or abolishes hallucinogenic activity. Nevertheless, MDMA is biologically active and has a potency only slightly less than its MDA parent. Importantly, it is the Ievo-isomer of hallucinogenic phenethylamines that is more biologically active, whereas it is the dextro isomer of MDMA that is more active. This reversal of stereochemistry for the activity of two very closely related molecules is a very powerful clue that their mechanisms of action differ. Finally, extension of the alpha-methyl of hallucinogenic amphetamines to an alpha-ethyl moiety completely abolishes their hallucinogenic activity. Ultimately, we extended the alpha-methyl group of MDMA to an alpha-ethyl to afford a molecule we named (N-Methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB) that retained significant MDMA-like psychoactivity. Hence, there are three structural features that distinguish MDMA from the hallucinogenic amphetamines: (1) the N-methyl on the basic nitrogen, (2) the reversal of stereochemistry and, (3) tolerance of an alpha-ethyl moiety as contrasted with the alpha-methyl of hallucinogenic phenethylamines. Clearly, MDMA is distinct from classical hallucinogenic phenethylamines in its structure, and its psychopharmacology is also unique. Thus, in 1986 I proposed the name “Entactogen” for the pharmacological class of drugs that includes 3,4-methylenedioxymethamphetamine (MDMA) and other substances with a similar psychopharmacological effect. The name is derived from roots that indicate that entactogens produce a “touching within.” Rather than having significant psychostimulant, or hallucinogenic effects, MDMA powerfully promotes affiliative social behavior, has acute anxiolytic effects, and can lead to profound states of introspection and personal reflection. Its mechanism of action is now established as involving transport of MDMA by the neuronal serotonin reuptake carrier followed by carrier-mediated release of stored neuronal serotonin.
Vulnerability to Ideologically-Motivated Violence Among Individuals With Autism Spectrum Disorder
Authors: Woodbury-Smith Marc R. , Loftin Rachel , Westphal Alexander , Volkmar Fred R.
Published: March 2022

People with autism spectrum disorder (ASD) are represented among those who espouse extremist thought and have committed violent acts associated with their beliefs. Media often highlight a perpetrator's psychiatric diagnosis following acts of mass violence, which in some instances has included ASD. ASD may itself not provide useful information for understanding motivations. Instead, understanding specific traits and neuropsychological and other vulnerabilities may offer an opportunity to make sense of these very complex events.
Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development
Authors: Zhang Anyi , Liu Lin , Chang Suhua , Shi Le , Li Peng , Shi Jie , Lu Lin , Bao Yanping , Liu Jiajia
Published: March 2022

Introduction

Autism spectrum disorder (ASD) is a lifelong condition. Autistic symptoms can persist into adulthood. Studies have reported that autistic symptoms generally improved in adulthood, especially restricted and repetitive behaviors and interests (RRBIs). We explored brain networks that are related to differences in RRBIs in individuals with ASDs among different ages.

Methods

We enrolled 147 ASD patients from the Autism Brain Imaging Data Exchange II (ABIDEII) database. The participants were divided into four age groups: children (6–9 years old), younger adolescents (10–14 years old), older adolescents (15–19 years old), and adults (≥20 years old). RRBIs were evaluated using the Repetitive Behaviors Scale-Revised 6. We first explored differences in RRBIs between age groups using the Kruskal–Wallis test. Associations between improvements in RRBIs and age were analyzed using a general linear model. We then analyzed RRBIs associated functional connectivity (FC) links using the network-based statistic method by adjusting covariates. The association of the identified FC with age group, and mediation function of the FC on the association of age-group and RRBI were further analyzed.

Results

Most subtypes of RRBIs improved with age, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors (p = 0.012, 0.014, and 0.012, respectively). Results showed that 12 FC links were closely related to overall RRBIs, 17 FC links were related to stereotyped behaviors. Among the identified 29 FC links, 15 were negatively related to age-groups. The mostly reported core brain regions included superior occipital gyrus, insula, rolandic operculum, angular, caudate, and cingulum. The decrease in FC between the left superior occipital lobe and right angular (effect = −0.125 and −0.693, respectively) and between the left insula and left caudate (effect = −0.116 and −0.664, respectively) might contribute to improvements in multiple RRBIs with age.

Conclusion

We identified improvements in RRBIs with age in ASD patients, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors. The decrease in FC between left superior occipital lobe and right angular and between left insula and left caudate might contribute to these improvements. Our findings improve our understanding of the pathogenesis of RRBIs and suggest potential intervention targets to improve prognosis in adulthood.
Complexities and Context of Scaling Up: A Qualitative Study of Stakeholder Perspectives of Scaling Physical Activity and Nutrition Interventions in Australia
Authors: Koorts Harriet , Maple Jaimie-Lee , Eakin Elizabeth , Lawrence Mark , Salmon Jo
Published: March 2022

Background

Scaling up population health interventions is a context-orientated, dynamic and multi-stakeholder process; understanding its influences is essential to enhance future scaling efforts. Using physical activity and nutrition interventions in Australia as case examples, the aim of this paper is to identify core influences involved in scaling up physical activity and nutrition interventions, and how these may differ by context and stakeholder.

Methods

A qualitative study involving semi-structured telephone interviews with individuals representing academic, government and non-government organizations with involvement in scaling up state and national physical activity and nutrition interventions. Interview questions were derived from the WHO report “20 Questions for Developing a Scaling up Case Study”, and mapped against four key principles and five core areas in the WHO ExpandNet framework for scaling up: (1) The innovation; (2) User organization; (3) Environment; (4) Resource team and; (5) Scale up strategy. Data were analyzed thematically.

Results

Nineteen interviews were conducted (government = 3; non-government = 5; and academic = 11 sectors) involving eight scaled up interventions, targeting nutrition (n = 2), physical activity (n = 1) or a combination (n = 5). Most themes aligned to the “Environment”, including: (i) political (e.g., personal agendas); (ii) social (e.g., lack of urgency); and (iii) sector/workforce (e.g., scale up accountability) factors. Themes relating to “Scale up strategy” (e.g., flexibility and evaluation transparency) were next most commonly occurring. Whilst themes were broadly consistent across participants, government participants had a more policy-oriented perspective on the scale up process. Academics discussed a tension between the generation and use of evidence, and the influence of political climates/interest on scale up decisions.

Conclusion

Attributes of the “Environment” and “Scale up strategy” consistently featured as major influences on successful outcomes, while the role of evidence differed greatly between participant groups. A multisector scale up strategy for future interventions may enable the complexities of environmental and political contexts to be incorporated into scale up planning.
Assessing the Documentation of Social Determinants of Health for Lung Cancer Patients in Clinical Narratives
Authors: Yu Zehao , Yang Xi , Guo Yi , Bian Jiang , Wu Yonghui
Published: March 2022

Social determinants of health (SDoH) are important factors associated with cancer risk and treatment outcomes. There is an increasing interest in exploring SDoH captured in electronic health records (EHRs) to assess cancer risk and outcomes; however, most SDoH are only captured in free-text clinical narratives such as physicians' notes that are not readily accessible. In this study, we applied a natural language processing (NLP) system to identify 15 categories of SDoH from a total of 10,855 lung cancer patients at the University of Florida Health. We aggregated the SDoH concepts into patient-level and assessed how each of the 15 categories of SDoH were documented in cancer patient's notes. To the best of our knowledge, this is one of the first studies to examine the documentation of SDoH in clinical narratives from a real-world lung cancer patient cohort. This study could guide future studies to better utilize SDoH information documented in clinical narratives.
Associations of Self-Care Health Behaviors With Driving Cessation Among Older Drivers
Authors: Mielenz Thelma J. , Whalen Adam M. , Xue Qian-Li , Andrews Howard , Molnar Lisa J. , Eby David W. , Li Guohua
Published: March 2022

Older adults are at risk of driving cessation as they age, which can result in negative health outcomes including loss of independence. This study aimed to investigate the associations of self-care health behaviors with the risk of driving cessation. Demographics, health and driving characteristics were captured from healthcare systems in Denver, CO, San Diego, CA, Ann Arbor, MI, Baltimore, MD and Cooperstown, NY for 2,990 adults at baseline then followed from July 2015 to January 2021 via in-person assessments and questionnaires. The follow-up accumulated a total of 7,348 person-years and 46 driving cessations, yielding an incidence rate of 0.63 per 100 person-years. Multivariable Cox proportional hazards regression was used to evaluate the relationship between self-care behaviors and driving cessation, stratified by gender, and accounting for multiple failure events and clustering by study site. Ability to participate in social roles and activities was associated with an 8% reduction in the risk of driving cessation [adjusted hazard ratio (HR): 0.92; 95% CI: 0.89, 0.94]. Increased participation in social activities and relationships is associated with driving longevity in older adults and should be targeted for interventions to maintain driving mobility.
Predictors of Weight Loss and Weight Loss Maintenance in Children and Adolescents With Obesity After Behavioral Weight Loss Intervention
Authors: Weiland Alisa , Nannette Lena Kasemann , Zipfel Stephan , Ehehalt Stefan , Ziser Katrin , Junne Florian , Mack Isabelle
Published: March 2022

Objective

Predictors of body weight loss (BWL) and body weight loss maintenance (BWLM) after behavioral weight loss intervention are well-investigated in adults. Less is known for children and adolescents and a systematic overview on the topic for this age group was aim of the review.

Methods

A systematic research according to PRISMA guidelines using several databases was performed. The outcome was the BMI z-Score of longitudinal studies. The extracted predictors were classified in clusters (Physiology, Behavior, Psychology, Environment) and compared with a theory-driven model based on international guidelines and known predictors for adults.

Results

Out of 2,623 articles 24 met the eligibility criteria, 23 investigating BWL and 8 BWLM. The expected key predictor in research for adults “Behavior” was hardly investigated in children. The most examined cluster was “Physiology” with the most significant predictors, in particular genetics (BWL) and blood parameters (BWLM). Factors in the cluster “Psychology” also predicted BWL and BWLM. The cluster “Environment,” which was highlighted in most intervention guidelines, was neglected in studies regarding BWLM and hardly investigated in studies with BWL.

Conclusion

The comparison with the theory-driven children model outlined research gaps and differences between predictors for adults and children providing further direction of research.

Systematic Review Registration

http://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42020200505.
Comparison of Psycho-Social Factors Associated With Suicidal Ideation and Suicide Attempts Among People Living With HIV in Central West China
Authors: Wang Xuelian , Yan Chuanyuan , Tong Yongsheng , Gao Juan , Zhou Wei , Lan Zhichao , Wu Jianlan , Li Hongbing , Yin Yi , Wang Yuehua , Liu Nancy H. , Deng Feng
Published: March 2022

Background

Previous studies have described the correlation of suicidal ideation (SI) or suicide attempts (SA) in people living with HIV (PLWH), whereas few studies compare the correlation between SI and SA in PLWH. Understanding specific risk factors for SI and SA among PLWH will help with developing tailored and effective suicide prevention strategies among this high-risk group.

Methods

A cross-sectional study was conducted from December 2020 to April 2021 in Baoji municipality, Shaanxi Province. The PLWH registered with the Baoji Municipal Center for Disease Control and Prevention (CDC) were recruited and interviewed. Questionnaires and interviews for this study consisted of socio-demographic variables, mental health history, and psychosocial characteristics. The HIV-related clinical features were obtained from CDC medical records. The PLWH included were divided into three groups, i.e., those with a history of suicide attempts (SA group), those with suicidal ideation only (SI group), and those without any suicidal behavior (NSB group). Multinomial logistic regression was used for three-way comparisons among these three groups of PLWH.

Results

In total, 995 PLWH were interviewed. The prevalence of probable depression, probable anxiety, SI, and SA in PLWH after being diagnosed as HIV+ was 18.6%, 13.5%, 26.7%, and 3.2%, respectively. Compared with the NSB group, the SI or SA groups were more likely to report probable depression [adjusted odds ratio (AOR) = 2.43, 4.44, respectively], probable anxiety (AOR = 2.80, 5.62, respectively), and high HIV-related stigma (AOR = 2.05, 2.65, respectively). The SI group was more likely to experience high HIV-related stress (AOR = 1.91) and lower quality of life (AOR = 0.56) than the NSB group. Social support and HIV-related clinical features were not associated with SI or SA in this sample. The SA group did not differ from the SI group on any of the psychosocial or HIV-related clinical features.

Conclusions

Mental health problems are serious in community residents identified with having an HIV infection in a Central West China municipality. It is important to deliver low-cost and effective psychological services tailored for PLWH that are focused on reducing mental health problems. Future studies should utilize sensitive screening measures and further clarify factors potentially associated with the transition from SI to SA in PLWH.
Applying Implementation Mapping to Expand a Care Coordination Program at a Federally Qualified Health Center
Authors: Dickson Kelsey S. , Holt Tana , Arredondo Elva
Published: March 2022

Background

A large and growing percentage of medically underserved groups receive care at federally qualified health centers (FQHCs). Care coordination is an evidence-based approach to address disparities in healthcare services. A partnered FQHC established a care coordination model to improve receipt and quality of healthcare for patients most at risk for poor health outcomes. This care coordination model emphasizes identification and support of behavioral health needs (e.g., depression, anxiety) and two evidence-based behavioral health programs needs were selected for implementation within the context of this care coordination model. Implementation Mapping is a systematic process for specifying the implementation strategies and outcomes. The current case study describes the application of Implementation Mapping to inform the selection and testing of implementation strategies to improve implementation of two behavioral health programs in a Care Coordination Program at a partnered FQHC.

Methods

We applied Implementation Mapping to inform the development, selection and testing of implementation strategies to improve the implementation of two evidence-based behavioral health programs within a care coordination program at a partnered FQHC.

Results

Results are presented by Implementation Mapping task, from Task 1 through Task 5. We also describe the integration of additional implementation frameworks (The Consolidated Framework for Implementation Research, Health Equity Implementation Framework) within the Implementation Mapping process to inform determinant identification, performance and change objectives development, design and tailoring of implementation strategies and protocols, and resulting evaluation of implementation outcomes.

Conclusions

The current project is an example of real-world application of Implementation Mapping methodology to improve care outcomes for a high priority population that is generalizable to other settings utilizing similar care models and health equity endeavors. Such case studies are critical to advance our understanding and application of innovative implementation science methods such as Implementation Mapping.
Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis
Authors: Gui Si-Yu , Chen Yue-Nan , Wu Ke-Jia , Liu Wen , Wang Wen-Jing , Liang Huan-Ru , Jiang Zheng-Xuan , Li Ze-Lian , Hu Cheng-Yang
Published: March 2022

Background

A large body of emerging evidence suggests that per- and polyfluoroalkyl substances (PFAS) affect birth outcomes in various pathways, but the evidence is inconsistent. Therefore, this study aimed to systematically review the epidemiological evidence on PFAS exposure and birth outcomes.

Methods

Three electronic databases were searched for epidemiological studies through February 13, 2021. We used random-effects meta-analysis for eight birth outcome indicators to calculate summary effect estimates for various exposure types. The risk of bias and the overall quality and level of evidence for each exposure-outcome pair were assessed.

Results

The initial search identified 58 potentially eligible studies, of which 46 were ultimately included. Many PFAS were found to have previously unrecognized statistically significant associations with birth outcomes. Specifically, birth weight (BW) was associated with PFAS, with effect sizes ranging from −181.209 g (95% confidence interval (CI) = −360.620 to −1.798) per 1 ng/ml increase in perfluoroheptanesulfonate (PFHpS) to −24.252 g (95% CI = −38.574 to −9.930) per 1 ln (ng/ml) increase in perfluorodecaoic acid (PFDA). Similar patterns were observed between other PFAS and birth outcomes: perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with birth length (BL) and ponderal index (PI), PFOS and perfluorododecanoic acid (PFDoDA) with head circumference (HC), PFHpS with gestational age (GA), and perfluorononanoic acid (PFNA) and PFHpS with preterm birth (PTB). Additionally, PFDA showed a statistically significant association with small for gestational age (SGA). The level of the combined evidence for each exposure-outcome pair was considered to be “moderate”.

Conclusion

This study showed that PFAS exposure was significantly associated with increased risks of various adverse birth outcomes and that different birth outcome indicators had different degrees of sensitivity to PFAS. Further studies are needed to confirm our results by expanding the sample size, clarifying the effects of different types or doses of PFAS and the time of blood collection on birth outcomes, and fully considering the possible confounders.
Planning Ability and Alertness After Nap Deprivation: Beneficial Effects of Acute Moderate-Intensity Aerobic Exercise Greater Than Sitting Naps
Authors: Du Jing , Huang Yujia , Zhao Ziqi , Wang Yajing , Xu Shuyu , Zhang Ruike , Xiao Lei , Xu Jingzhou , Wang Hao , Su Tong , Tang Yunxiang
Published: March 2022

Nap deprivation is regarded as a sleep loss for habitual nappers. The beneficial effects of napping and moderate-intensity aerobic exercise on the reduction in planning ability following nighttime sleep deprivation have been proven. However, it is still unknown whether it can improve the performance decline caused by daytime nap deprivation in habitual nappers. Seventy-four healthy adults who had a long-term habit of taking naps were assigned to three interventions after receiving nap deprivation: (1) Control group (no intervention); (2) Nap group (15-min sitting naps); (3) Exercise group (15-min aerobic exercise), in which subjective alertness, mood, fatigue, and task performance in objective alertness (Psychomotor Vigilance Task, PVT) and planning ability (the Tower of London Task) were measured. Results showed that nap deprivation negatively influenced some performance on the psychomotor vigilance (i.e., response times and 10% slowest response time) and planning ability (i.e., planning time). And acute moderate-intensity aerobic exercise improved psychomotor alertness (i.e., response times) and planning ability (i.e., execution accuracy, execution time), a 15-min sitting naps only alleviated subjective fatigue, whereas some performance (i.e., response times) deteriorated when no intervention was used. These findings suggested that acute moderate-intensity aerobic exercise has a better restorative effect on the reduced planning ability and objective alertness due to nap deprivation compared to sitting naps.
Professional Identity of 0.24 Million Medical Students in China Before and During the COVID-19 Pandemic: Three Waves of National Cross-Sectional Studies
Authors: Yu Chen , Liu Qiao , Wang Weimin , Xie Ana , Liu Jue
Published: March 2022

Background

Professional identity (PI) influences the doctor's thoughts and behaviors. Thus, PI formation (PIF) plays an important role in medical students' education. Major changes to the learning environment could impact PIF, but the influence of the novel coronavirus disease 2019 (COVID-19) pandemic on medical students' PI had confusing conclusions in previous studies. We aimed to compare PI of medical students by using the data from three waves of national cross-sectional surveys conducted in China in 2019, 2020, and 2021, and to examine factors that influence PIF.

Method

We used data from the China Medical Student Survey (CMSS) which has conducted three national cross-sectional surveys. From 2019 to 2021, CMCC retrieved data on PI from a nationally representative sample of medical students from 33, 121, and 123 colleges, respectively. We analyzed the data using Chi-square test, analysis of variance, and multivariable logistic regression according to sociodemographic characteristics, pre-university experience, college characteristics, and college experience.

Results

A total of 244,040 medical students in China participated in the surveys. The overall score of PI increased from 3.80 in 2019 to 3.85 in 2021. Medical students with family medical background, high intrinsic and extrinsic motivation of major selection, teachers' positive role model, and high personal comprehensive quality ranking were more likely to have higher PI (all p < 0.05). The more attention students paid to the COVID-19 pandemic, the higher PI they would have (aOR 1.93, 95% CI 1.67–2.24 for more attention; aOR 2.31, 95% CI 2.00–2.68 for the most attention). However, parents' participation on the front lines of COVID-19 pandemic negatively influenced the PI of medical students (aOR 0.72, 95% CI 0.57–0.93).

Conclusions

PI of medical students increased during the COVID-19 pandemic. The impact of the pandemic on PI was complex. To improve the PI of medical students, the education sector, health sector and the society need to make concerted efforts.
Hijacking Cellular Stress Responses to Promote Lifespan
Authors: Dutta Naibedya , Garcia Gilberto , Higuchi-Sanabria Ryo
Published: March 2022

Organisms are constantly exposed to stress both from the external environment and internally within the cell. To maintain cellular homeostasis under different environmental and physiological conditions, cell have adapted various stress response signaling pathways, such as the heat shock response (HSR), unfolded protein responses of the mitochondria (UPRMT), and the unfolded protein response of the endoplasmic reticulum (UPRER). As cells grow older, all cellular stress responses have been shown to deteriorate, which is a major cause for the physiological consequences of aging and the development of numerous age-associated diseases. In contrast, elevated stress responses are often associated with lifespan extension and amelioration of degenerative diseases in different model organisms, including C. elegans. Activating cellular stress response pathways could be considered as an effective intervention to alleviate the burden of aging by restoring function of essential damage-clearing machinery, including the ubiquitin-proteosome system, chaperones, and autophagy. Here, we provide an overview of newly emerging concepts of these stress response pathways in healthy aging and longevity with a focus on the model organism, C. elegans.
Is Class-Incremental Enough for Continual Learning?
Authors: Cossu Andrea , Graffieti Gabriele , Pellegrini Lorenzo , Maltoni Davide , Bacciu Davide , Carta Antonio , Lomonaco Vincenzo
Published: March 2022

The ability of a model to learn continually can be empirically assessed in different continual learning scenarios. Each scenario defines the constraints and the opportunities of the learning environment. Here, we challenge the current trend in the continual learning literature to experiment mainly on class-incremental scenarios, where classes present in one experience are never revisited. We posit that an excessive focus on this setting may be limiting for future research on continual learning, since class-incremental scenarios artificially exacerbate catastrophic forgetting, at the expense of other important objectives like forward transfer and computational efficiency. In many real-world environments, in fact, repetition of previously encountered concepts occurs naturally and contributes to softening the disruption of previous knowledge. We advocate for a more in-depth study of alternative continual learning scenarios, in which repetition is integrated by design in the stream of incoming information. Starting from already existing proposals, we describe the advantages such class-incremental with repetition scenarios could offer for a more comprehensive assessment of continual learning models.
Behind the Leaves: Estimation of Occluded Grapevine Berries With Conditional Generative Adversarial Networks
Authors: Kierdorf Jana , Weber Immanuel , Kicherer Anna , Zabawa Laura , Drees Lukas , Roscher Ribana
Published: March 2022

The need for accurate yield estimates for viticulture is becoming more important due to increasing competition in the wine market worldwide. One of the most promising methods to estimate the harvest is berry counting, as it can be approached non-destructively, and its process can be automated. In this article, we present a method that addresses the challenge of occluded berries with leaves to obtain a more accurate estimate of the number of berries that will enable a better estimate of the harvest. We use generative adversarial networks, a deep learning-based approach that generates a highly probable scenario behind the leaves exploiting learned patterns from images with non-occluded berries. Our experiments show that the estimate of the number of berries after applying our method is closer to the manually counted reference. In contrast to applying a factor to the berry count, our approach better adapts to local conditions by directly involving the appearance of the visible berries. Furthermore, we show that our approach can identify which areas in the image should be changed by adding new berries without explicitly requiring information about hidden areas.
Bruce Lee-Inspired Fluid Antenna System: Six Research Topics and the Potentials for 6G
Authors: Wong Kai-Kit , Tong Kin-Fai , Shen Yuanjun , Chen Yu , Zhang Yangyang
Published: March 2022

While 5G is tasked to transform our lives for the better over the next 10 years, next-generation mobile communications, a.k.a. 6G, will undoubtedly demand even higher energy and spectral efficiencies capable of providing myriads of new services and experience to users everywhere they go. Although our technologies do evolve from one generation to the next, the root of the ambition in mobile communications has always been to ensure reliable performance from an uncertain, fluctuating medium. The previous generations have already seen numerous technologies such as advanced coding and signal processing, resource allocation, and most famously, multiple-input multiple-output to redeem some stability from the wireless medium. Inevitably, 6G will be built upon further disruptive technologies that enable another cycle of revolution. In this article, we examine one emerging technology, referred to as fluid antenna system that represents any software-controllable fluidic, conductive, or dielectric structure that can alter its shape and position to reconfigure the gain, radiation pattern, operating frequency, and other characteristics. Fluid antenna takes inspiration from Bruce Lee's Jeet Kune Do to innovate mobile communication systems design. In Bruce Lee's philosophy, one can imitate water to adapt combat style, whereas fluid antenna exploits the dynamic nature of fluids or switchable pixels to achieve ultimate flexibility for diversity and multiplexing benefits that have been unseen before in mobile devices, and the implication can be transformative. This article discusses the potential of fluid antenna systems for 6G, and in particular, we introduce six research topics in fluid antenna systems that if solved successfully could revolutionize mobile communications network design and optimization. This article intends to stimulate discussion that will help shape the development of 6G technologies.
Utilization of Mid-Thigh Magnetic Resonance Imaging to Predict Lean Body Mass and Knee Extensor Strength in Obese Adults
Authors: Bodkin Stephan G. , Smith Andrew C. , Bergman Bryan C. , Huo Donglai , Weber Kenneth A. , Zarini Simona , Kahn Darcy , Garfield Amanda , Macias Emily , Harris-Love Michael O.
Published: March 2022

Purpose

To train and test a machine learning model to automatically measure mid-thigh muscle cross-sectional area (CSA) to provide rapid estimation of appendicular lean mass (ALM) and predict knee extensor torque of obese adults.

Methods

Obese adults [body mass index (BMI) = 30–40 kg/m2, age = 30–50 years] were enrolled for this study. Participants received full-body dual-energy X-ray absorptiometry (DXA), mid-thigh MRI, and completed knee extensor and flexor torque assessments via isokinetic dynamometer. Manual segmentation of mid-thigh CSA was completed for all MRI scans. A convolutional neural network (CNN) was created based on the manual segmentation to develop automated quantification of mid-thigh CSA. Relationships were established between the automated CNN values to the manual CSA segmentation, ALM via DXA, knee extensor, and flexor torque.

Results

A total of 47 obese patients were enrolled in this study. Agreement between the CNN-automated measures and manual segmentation of mid-thigh CSA was high (>0.90). Automated measures of mid-thigh CSA were strongly related to the leg lean mass (r = 0.86, p < 0.001) and ALM (r = 0.87, p < 0.001). Additionally, mid-thigh CSA was strongly related to knee extensor strength (r = 0.76, p < 0.001) and moderately related to knee flexor strength (r = 0.48, p = 0.002).

Conclusion

CNN-measured mid-thigh CSA was accurate compared to the manual segmented values from the mid-thigh. These values were strongly predictive of clinical measures of ALM and knee extensor torque. Mid-thigh MRI may be utilized to accurately estimate clinical measures of lean mass and function in obese adults.
Quality of Life Outcomes in a Community Cohort of Adults With an Intellectual Disability Using the Personal Outcome Scale
Authors: Burke Tom , Deffew Andrew , Stafford Owen , Docherty Caroline , Burke Sandra , Mostert Remco , van Loon Jos , Lombardi Marco , Vaughan Marianne , Brickell Robert , Keogh Mary , Mahon Wendy , O'Halloran David
Published: March 2022

Objectives

Quality of life (QoL) is a multi-dimensional phenomenon composed of core domains that are influenced by personal characteristics, values, and environmental contributions. There are eight core domains of QoL aligned with both the United Nations and the International Association for the Scientific Study of Intellectual and Developmental Disabilities (IASSIDD). The Personal Outcome Scale (POS), is a semi-structured self and proxy instrument that specifically measures these aspects of QoL for people with an intellectual disability.

Methods

A total of 85 people with an intellectual disability and their primary keyworker (n = 85) took part in this study. A convenience sample recruitment strategy was employed to recruit participants during the calendar year from January–December 2020. Participants completed the self-report and proxy POS, and clinic-demographic data was also considered.

Results

QoL is higher in those who have a dedicated service planner and also for those with a less severe to profound disability. People who were in gainful employment reported significantly higher QoL as did those availing of outreach and residential services, over and above local services.

Conclusions

This research shows that there are distinct and specific factors that relate to QoL for people with an intellectual disability community-based services in Ireland. Future research could aim to investigate these longitudinally, and specifically how QoL relates to cognitive and functional outcomes.
Opening Up of Editorial Activities at Chemistry Journals. What Does Editorship Mean and What Does It Involve?
Authors: Noel Marianne
Published: March 2022

The article unpacks the publishing practices and focuses on the curating work carried out by the editors of chemistry journals. Based on a qualitative analysis of multiple sources in two publishing houses (the American Chemical Society, ACS and Nature Research), it first shows that the role of editor-in-chief covers a wide range of realities and is far from being limited to that of a gatekeeper (the most common metaphor in the literature). In journals that are part of the Nature Research portfolio, in-house editors, who are no longer active scientists, work full time for the journals. The article describes the professional trajectories and skills required to join the publishing house. Interviews highlight collective identity-based actions, attention to the growth and the flow of manuscripts, but also specific epistemic properties of outputs in chemistry. Besides tasks that editors outline “as really the same as they were 100 years ago,” as they spend most of their time handling manuscripts and providing quality assurance, they also travel to conferences to support journals and encourage submissions, visit labs where researchers pitch their work or ask questions about journals, and “educate the actors themselves” about new fields. In both cases studied, the publishing houses partner with institutions to offer events (ACS on Campus programme, Nature masterclass) that a university or department can freely host or buy, where editors organize workshops on all aspects of manuscript preparation. Second, publishing houses, whether non-for-profit or commercial, have embraced a catalog logic, where the journals are not necessarily in competition and have an assumed place and hierarchy. At Nature Research, editors-in-chief head business units inscribed in the company's organization. Despite standardized processes imposed by the procedural chain, there is still room to maneuver in these relatively autonomous structures that are ultimately evaluated on their results (the annual production of a certain number of high-quality papers). On the other hand, ACS is seen as a vessel whose course cannot easily be deviated. The conclusion calls for extending this type of investigation to other contexts or types of journals.
Understanding the Sexual and Reproductive Health Experiences of Refugee and Host Community Adolescents and Youth in Rwanda During COVID-19: Needs, Barriers, and Opportunities
Authors: Meyer Katherine , Abimpaye Monique , Harerimana Jean de Dieu , Williams Christina , Gallagher Meghan C.
Published: March 2022

Background

COVID-19 has exacerbated the sexual and reproductive health (SRH) needs of those affected by humanitarian emergencies, particularly affecting adolescents and youth, whose needs are often neglected during crises. In Rwanda, the situation for refugees in Mahama Refugee Camp has worsened, as COVID-19 lockdown measures have increased needs while restricting access to basic services. Few assessments have been conducted on the SRH needs of refugees in Mahama camp, including adolescents and youth, since COVID-19. To address this gap, Save the Children (SC) undertook research utilizing SenseMaker to collect data on the SRH needs of adolescents and youth in Mahama camp, as well as in the surrounding host community.

Methodology

SC used SenseMaker to collect 745 data entries from adolescents and youth in Mahama camp and the surrounding host community. The application was pretested with adolescents and youth in Mahama camp before initiating the research. SenseMaker asks participants to share their stories in response to a prompt; our prompt asked participants to describe their experience seeking help with their health during COVID-19. The research team analyzed the data using simultaneous coding to examine key themes. The results were discussed with SC staff to validate the coding analysis results before conducting four focus group discussions to further clarify results and propose action steps in response to the findings.

Results

Many adolescents and youth reported significant difficulties accessing SRH information and services, including stigmatization among service providers. Provider biases and negative attitudes were repeatedly cited as barriers. Stories collected during COVID-19 show how these biases and judgmental attitudes continue to adversely affect access and use of SRH services for young people. Coercive, non-consensual, and transactional sexual incidents were reported from adolescents and youth. They cited reduced time in education spaces as a source of distress as well as increasing their level of sexual activity and associated risks. Limited data exists for SRH needs among adolescents and youth during COVID-19 in humanitarian settings. This study adds to the evidence, making the case for increased SRH prioritization for adolescents and youth in humanitarian settings, particularly when facing overlapping crises like during the COVID-19 pandemic.