bluuebunny/crossref_metadata_2025 huggingface dataset:
The Butterflies (Lepidoptera, Papilionoidea) of Fastiv district (Kyiv Region, Ukraine)
Authors: Yepishin V. V.
Published: February 2019

The results of faunistic research on butterflies carried out at 2011–2018 on the territory of Fastiv District are presented. Thus, 71 species from 50 genera and 6 families are recorded over the years of research. The number of identified species constitutes 56,1% of the fauna of Kyiv Region and 37,2% of the fauna of Ukraine. Three species, Iphiclides podalirius (Linnaeus, 1758), Papilio machaon Linnaeus, 1758 (family Papilionidae) and Hamearis lucina (Linnaeus, 1758) (family Riodinidae), are included in the Red Data Book of Ukraine. Iphiclides podalirius (Linnaeus, 1758) was abundant and frequently recorded during at the last 2 years; about 10 localities are known for this species. Papilio machaon Linnaeus, 1758 was found in six localities of Fastiv District and was frequently recorded every year. Hamearis lucina (Linnaeus, 1758) was found at one locality in 2018 only. Twenty eight species from 21 genera (families Hesperiidae, Pieridae, Papilionidae, Lycaenidae and Nymphalidae) are ubiquitous and were found in more than four localities; 22 species from 20 genera (families Hesperiidae, Pieridae, Lycaenidae and Nymphalidae) were common and found in 2–4 localities; 21 species from 16 genera (families Hesperiidae, Pieridae, Riodinidae, Lycaenidae and Nymphalidae) occured very locally and are known from one locality in the studied region. Moreover, three species: Limenitis populi (Linnaeus, 1758), Aglais urticae (Linnaeus, 1758), Nymphalis polychloros (Linnaeus, 1758) (family Nymphalidae) have not been recorded in Fastiv District for last 40 years; these species are known by the matrial from collections of the second half of last century only.
Spatial-typological structure of blackflies communities (Diptera: Simuliidae) of the River Tisa basin within of the Ukrainian Carpathians
Authors: Tepliuk A. M. , Sukhomlin K. B.
Published: February 2019

A total of 46 species of blackflies from 2 genera were recorded in the watercourses of the Tisa River basin within Ukrainian Carpathians. In qualitative terms, the genus Simulium Latreille, 1802 predominates, with 42 species in 5 subgenera: Nevermannia Enderlein, 1921 (9 species), Eusimulium Roubaud, 1906 (2 species), Wilhelmia Enderlein, 1921 (4 species), Obuchovia Rubtsov, 1947 (2 species) and Simulium Latreille, 1802 (25 species). The genus Prosimulium Roubaud, 1906 is represented with only 4 species. Moreover, 33 species develop in streams (the index of the species diversity of Simpson (Is) is 0,094), and 32 species (Is – 0,087) of Simuliidae develop in rivers. There are 19 common species for both types of watercourses (the index of similarity of Chekanovsky-Sorensen (I) is 0.37). Only 14 species of blackflies develop in streams, and only 13 species develop in rivers. Two dominant species (S. (s.str.) intermedium, S. (s.str.) trifasciatum) and 4 subdominant species (S. (s.str.) argyreatum, S. (s.str.) ornatum, S. (s.str.) reptans, S. (s.str.) variegatum) form the nucleus of the fauna Simuliidae of the Tisa River basin. The species diversity of blackflies reaches 33 species (Is – 0,075) at watercourses of the low mountain level (at altitudes up to 499 m), is has 38 species (Is – 0,067) at the middle mountain level (500–999 m) and only 24 species (Is – 0,021) at high mountain level (above 1000 m). Only 6 species (S. (Eusimulium) velutinum, S.(Obuchovia) brevifile, S. (s.str.) noelleri, S. (s.str.) rostratum, S. (s.str.) tuberosum and S. (s.str.) voilense) develop in the watercourses of the low mountain level, 5 blackfly species (S. (Nevermannia) codreanui, S. (Wilhelmia) pseudoequinum, S. (s.str.) argenteostriatum, S. (s.str.) paramorsitans and S. (s.str.) vulgare) develop in the watercourses of the middle mountain level and 2 species blackflies (S. (Nevermannia) crenobium and S. (Nevermannia) oligotuberculatum) develop in the watercourses of the high mountain level. There are 16 species of Simuliidae common for this high altitude belts, among them S. (Nevermannia) vernum, S. (s.str.) fontanum, S.(s.str.) intermedium, S.(s.str.) ornatum and S. (s.str.) trifasciatum did not reveal the definite patterns of belonging to the specific altitudes, since their quantity was approximately the same at different heights.
Analysis of Traffic Noise in Taman Kota Lumintang Denpasar
Authors: Pradana Adrian , Tamba I Made , Widnyana I Ketut
Published: February 2019

This research was conducted to analyze the level of traffic noise in Lumintang City Park, Denpasar. The measurement method is by using a direct method that is using an integrating sound level meter that has an LTMS measurement facility, namely Leq with a measuring time every 5 seconds. The examination is carried out by measuring for 10 minutes. The measurement time is carried out during the 24 hour activity (NGO) on December 3, 2018. The measurement distance ranges from 5-10 meters from the road, with a height of 1-1.2 m from the ground level. The results of the research on the level of traffic noise in Lumintang City Park Denpasar showed the noise level that exceeded the noise level quality standards of the green open space area of 50 dB, where in the first lane the traffic noise level was 92.52 dB at L3. While the noise research in lane 2 shows that the highest traffic noise level of 85.70 dB occurs at L5. For day and night (NGO) noise levels in lane 1 amounting to 70.13 dB and lane 2 of 67.95 dB has exceeded the quality standard of green open space, so that it can cause physical and psychological disturbances for visitors to the Taman Lumintang City of Denpasar..
Analysis of Budget Planning, Competence of Human Resources and Implementation of the Viii Lldikti Region Budget with Organizational Commitment as A Moderation
Authors: Sari Luh Gede Eka , Yuesti Anik , Sudja I Nengah , Kepramareni Putu
Published: February 2019

The aim of research to analysis factors that effect to absorption of the budget. The factors that affects the absorption of the budget are budget planning, Human resources kompetence, and commitment. Limited sources of state revenue require the government to prioritize activities and allocate effective and efficient budgets. Failure to target the absorption of the budget indicates an inefficiency and the ineffectiveness of budget allocations (Carsidiawan, 2009). This research will be conducted at LLDIKTI Region VIII, Denpasar-Bali. The sampling technique used is saturated sample because researchers want to make generalizations with relatively small errors.. The number of samples in this study is 36. Testing the effect of budget planning, HR competence on budget absorption using multiple regression analysis. Moderated Regression Analysis (MRA) with interaction tests is used to test the effect of the moderating variable interactions. The following equation model is used to answer hypothesis 1 (H₁), hypothesis 2 (H₂), hypothesis 3 (H₃) and hypothesis 4 (H₄). The result research show that: Budget planning has a statistically positive effect on the absorption of the Region VIII LLDIKTI budget. HR competencies have a statistically positive effect on the absorption of the Region VIII LLDIKTI budget. Organizational commitment strengthens the influence of budget planning on the absorption of the Region VIII LLDIKTI budget. Organizational commitment does not strengthen the influence of HR competencies on the absorption of the Region VIII LLDIKTI budget.
Relationship of Knowledge, Attitude and Infrastructure Means with Community Behavior in the Eradication Dengue Hemorrhagic Fever in Port of Padangbai Karangasem
Authors: Sudarmika I Gusti Agung Gede , Maba I Wayan , Widnyana I Ketut
Published: February 2019

Dengue hemorrhagic fever (DHF) is a disease that is still a problem in Indonesia, including Bali. The Padangbai Karangasem port area is one of the entrances to countries that are not yet free from dengue fever cases, because there are still reported cases of dengue fever. The number of House of Aedes Flicking Index is still more than 1%. Based on Minister of Health Decree number 431 of 2007 Port Buffer Area <1%. The implementation of the Mosquito Nest Eradication through 3M Plus is the most effective effort to prevent the transmission of Dengue Hemorrhagic Fever.The purpose of this study was to determine the relationship between knowledge, attitudes and infrastructure with the behavior of implementing the Eradication of Dengue Hemorrhagic Fever Nests. The research design was quantitative with a cross sectional design. This research was conducted in the Padangbai Karangasem Port Area, Bali. Data collection used a questionnaire about Knowledge, Attitudes,facilities and infrastructure and Behavior for Eradicating Dengue Hemorrhagic Fever Eradication. The number of samples of 89 respondents was taken proportional random sampling. The results showed that Knowledge, Attitudes and Infrastructure were significantly related to the eradication behavior of dengue fever mosquitoes due to the value of p<α=0.,05. The most dominant variable associated with the implementation behavior of Eradication of Dengue Hemorrhagic Fever Eradication is Knowledge Variable because the highest OR value is 4.287 compared to Attitudes and infrastructure.
Problematic video game use as an emotional coping strategy: Evidence from a sample of MMORPG gamers
Authors: Blasi Maria Di , Giardina Alessandro , Giordano Cecilia , Coco Gianluca Lo , Tosto Crispino , Billieux Joel , Schimmenti Adriano
Published: February 2019

Background

A positive relationship between problematic gaming and escapism motivation to play video games has been well established, suggesting that problematic gaming may result from attempts to deal with negative emotions. However, to date, no study has examined how emotion dysregulation affects both escapism motives and problematic gaming patterns.

Methods

Difficulties in emotion regulation, escapism, and problematic involvement with video games were assessed in a sample of 390 World of Warcraft players. A structural equation modeling framework was used to test the hypothesis that escapism mediates the relationship between emotion dysregulation and problematic gaming.

Results

Statistical analyses showed that difficulties in emotion regulation predicted both escapism motives and problematic gaming, and that escapism partially mediated this relationship.

Conclusion

Our findings support the view that problematic players are likely to escape in online games as a maladaptive coping strategy for dealing with adverse emotional experiences.
The trash becomes profit for Brazilian grocery retail
Authors: Braga Junior Sergio Silva , Dias Karina Tonelli Silveira , Braga Waleska Reali de Oliveira , Forti Juliane Cristina
Published: February 2019

Environmental sensitivity is present in several countries, and in Germany and the Netherlands, this perception on the part of agents (companies and individuals) is quite high. In this context, retailers have begun to take on new tasks, such as the commitment to reduce the waste they generate and to recycle and reuse what is generated with the purpose of increasing their responsibility to the final consumer. Therefore, the aim of this work was to analyze the reverse logistics implemented in 22 grocery stores located in São Paulo (Brazil) and to quantify the profit obtained with this implementation. For this, for 24 months, the quantities of cardboard and plastic discarded by these grocery stores were monitored. As a result, it was possible to observe that the supermarket corporation increased its net profit with the practice of reverse logistics in a value proportional to the net profit generated by two supermarkets with a revenue of 600 thousand dollars.ResumenLa sensibilidad ambiental está presente en varios países, y en Alemania y los Países Bajos, esta percepción por parte de los agentes (empresas e individuos) es bastante alta. En este contexto, los minoristas han comenzado a asumir nuevas tareas, como el compromiso de reducir el desperdicio que generan y reciclar y reutilizar lo que se genera con el fin de aumentar su responsabilidad ante el consumidor final. Por lo tanto, el objetivo de este trabajo fue analizar la logística inversa implementada en 22 supermercados ubicados en São Paulo (Brasil) y cuantificar los beneficios obtenidos con esta implementación. Para esto, durante 24 meses, se monitorearon las cantidades de cartón y plástico desechadas por estas tiendas de comestibles. Como resultado, se pudo observar que la corporación de supermercados aumentó sus ganancias netas con la práctica de logística inversa en un valor proporcional al beneficio neto generado por dos supermercados con un ingreso de 600 mil dólares.ResumoA sensibilidade ambiental está presente em vários países e, na Alemanha e na Holanda, essa percepção por parte dos agentes (empresas e indivíduos) é bastante alta. Nesse contexto, os varejistas começaram a assumir novas tarefas, como o compromisso de reduzir o desperdício que geram e a reciclar e reutilizar o que é gerado com o objetivo de aumentar sua responsabilidade para o consumidor final. Portanto, o objetivo deste trabalho foi analisar a logística reversa implementada em 22 supermercados localizados em São Paulo (Brasil) e quantificar o lucro obtido com essa implementação. Para isso, durante 24 meses, as quantidades de papelão e plástico descartadas por esses supermercados foram monitoradas. Como resultado, foi possível observar que a empresa de supermercados aumentou seu lucro líquido com a prática da logística reversa em um valor proporcional ao lucro líquido gerado por dois supermercados com uma receita de 600 mil dólares.
The Crisis of Health Professions Education in Pakistan
Authors: Javaeed Arslaan
Published: February 2019

This article was migrated. The article was marked as recommended. Health professions are critical in maintaining the health infrastructure of the country. The quality of health care education imparted directly affects the people and it is thus very important to focus our attention towards it. This paper is focused on the current dilemmas being faced in the health professions education and a two-step solution was proposed in view of the deep understanding of the problem. The first step includes a teacher training course to educate and empower the educator about the current advancements in the healthcare professions education. The second step included a thorough evaluation of medical educators to assess their teaching practices and bring forward solutions to improve them. Undoubtedly it can be stated that there is a dire need to implement principles of health professions education in Pakistan and educators have to play their crucial role in understanding the current challenges and taking steps to overcome them.
The relationship of plasma catestatin and heart rate variability parameters in middle-aged men with primary hypertension
Authors: Gubareva E. Yu. , Kryukov N. N. , Gubareva I. V.
Published: February 2019

Aim.To study the catestatin plasma level in patients with primary hypertension of different cardiovascular risk and to assess its relationship with heart rate variability (HRV) parameters.

Material and methods. One hundred eighty men aged 30-50 years were divided into groups: group 1 (n=28) — hypertensive patients with medium risk of developing cardiovascular complications (CVC), group 2 (n=76) — hypertensive patients with high risk of CVC, group 3 (n=31) — hypertensive patients with very high risk of CVC. The control group consisted of healthy men with normal blood pressure (BP) (n=45). We determined plasma catestatin (ng/ml) and conducted Holter monitoring.

Results.A pattern was found to reduce the concentration of catestatin with increasing risk of CVC in hypertensive patients, but there were no significant differences between the studied groups (p>0,05).

We determined corrections between catestatin levels and echocardiography thickness of left ventricular posterior wall (r=-0,523; p=0,045) and interventricular septum (r=-0,523, p=0,045) in diastole in group 2; thickness of left ventricular posterior wall (r=0,258; p=0,035) and interventricular septum (r=0,254; p=0,038) in systole in group 3. In patients of group 2, direct correlations of catestatin levels and sympathicotonia LF/HF were revealed during the whole observation period (r=0,301; p=0,019) and during wakefulness (r=0,308; p=0,019); inverse correlations — with parameters of parasympathetic tone: nHF during the whole observation time (r=-0,318; p=0,013) and during wakefulness (r=-0,342; p=0,007), pNN50 in the afternoon (r=-0,270; p=0,037).

Conclusion.A decrease in catestatin concentrations in hypertensive patients is associated with the progression of disease and an increase in cardiovascular risk. It is assumed that catestatin is involved in the formation of HRV in patients with primary hypertension.
PREDICTORS OF ARTERIAL HYPERTENSION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN AZERBAIJAN POPULATION
Authors: Mekhdiyev S. Kh. , Mustafaev I. I. , Mamedov M. N.
Published: February 2019

The presented study in Azerbaijan is carried out for the first time within State Programs on fight against a type 2 diabetes mellitus (DM2) and other noninfectious diseases.

Aim.To define predictors of arterial hypertension (AH) in patients with DM2 in Azerbaijan population.

Material and methods. In the single-step clinical-epidemiology cohort study were included 528 patients with DM2 at the age of 30-69 (30,5% — men and 69,5% — women) who answered questions using “ARIC” questioner to define AH and its risk factors.

Results.The prevalence of AH in women (72,4%) was 2,6 times more than in men (27,6%) and the frequent occurrence of AH was at the age of 60-69 (respectively, 26,7±2,1% vs 9,6±2,9%, p<0,001). It was not determined remarkable differences between AH level and occupation status, alcohol consumption, low physical activity, feeding disorder of the patients, at the same time in patients with AH smoking frequency was about 2 times often than in others (respectively, 19,3±1,9% vs 10,6±3,0%, p<0,05). In parents of AH patients AH rates, in comparison with eutonics, were occurred like these: (respectively, in fathers 21,9±2,0% vs 12,5±3,2%, p<0,05; in mothers 42,2±2,4% vs 26,9±4,3%, p<0,01), in mothers DM2 (respectively, 33,7±2,3% vs 221 ±4,1 %, p<0,05), overweight and obesity were watched much more often (95,0±1,1% vs 88,5±3,1%, p<0,05), at the same time these patients were suffered from abdominal obesity (respectively, 96,5±0,9% vs 89,4±3,0%, p<0,01). The mean values of systolic and diastolic arterial pressure (respectively, 148,3±1,1 vs 119,8±1,3 Hg, p<0,001 and 85,9±0,5 vs 74,8±0,8 Hg, p<0,001) were often determined in patients with AH, and on the other hand in these patients were noted prevalence of anxious syndrome (respectively, 78,5±2,0% vs 72,1±4,4%, p<0,05) and depression (68,2±2,3% vs 62,5±4,7%, p>0,05). Regardless of AH level in all patients was noted stress (respectively, 99,8±0,2% vs 100,0±0,0%, p>0,05), which changed for the worse life quality of the patients with AH significantly (respectively, 1,0±2,2% vs 61,5±4,8%, p<0,05).

Conclusion.For patients with DM2 in Azerbaijan cohort female sex, increasing of the age, body mass index, abdominal obesity and anxious conditions are significant risk factors for AH. Presence of AH in both parents and DM2 in mothers increase this risk significantly, which decrease life quality of these patients.
Influence of arterial hypertension, smoking, and their combination on mortality (according to the results of a 27-year cohort prospective study of the unorganized population of Tomsk)
Authors: Dolgalev I. V. , Brazovskaya N. G. , Ivanova A. Yu. , Shipkhineeva A. Yu. , Bogaychuk P. M.
Published: February 2019

Aim.To study the influence of arterial hypertension (AH), smoking, and their combination on the risk of all cause and cardiovascular mortality.

Material and methods. We conducted a 27-year cohort prospective study of the unorganized population of Tomsk (916 women and 630 men aged 20-59 years). At the first stage, we studied the prevalence of AH and smoking (1998-1991), at the second (2015) — the effect of these risk factors (RF) and their combination on the risk of all cause and cardiovascular mortality. AH was diagnosed at a blood pressure level of >140/90 mmHg and <140/90 mm Hg in individuals taking antihypertensive drugs. Smokers were individuals who smoked at least 1 cigarette per day and quit smoking less than one year ago.

Results.The study found a significant effect of AH and smoking on mortality: the relative risk (RR) of all-cause mortality in people with hypertension was 2,2, in smokers — 2,3, in those with a combination of RF — 5,0. The RR of cardiovascular mortality in AH individuals was 3,4, in smokers — 1,6, in smoking men and women suffering from AH — 5,2. An increase in the risk of all-cause mortality in people with AH and smoking was observed in all gender-age groups. Smoking was found to increase the risk of all-cause mortality in individuals with high levels of blood pressure by 2,1 times compared with non-smoking hypertensive patients. It reduces the chances of a 27-year survival rate to 64,4%, and more so in the youngest (20-39 years) age group (RR — 3,9). Multivariate analysis showed that AH and smoking make the most significant contribution to the formation of mortality compared to other modifiable RFs.

Conclusion.We found that AH and smoking are among the most influential RFs, and their combination increases the RR of all-cause mortality by 5,0 times (cardiovascular — 5,2 times). We also determined an additional risk of smoking in individuals suffering from AH to the all-cause mortality.
Pharmacoeconomic effectiveness of using modern technologies in the follow-up care of patients with arterial hypertension
Authors: Efanov A. Yu. , Medvedeva I. V. , Shalaev S. V. , Petrov I. M. , Yusupova E. Yu. , Volkova S. Yu. , Petrova Yu. A.
Published: February 2019

Aim. To conduct a pharmacoeconomic assessment of the use of modern technologies in the follow-up care of patients with arterial hypertension (AH) in the Tyumen region.

Material and methods. Using a random sampling technique we selected and examined 1704 patients with AH in the Tyumen region. The average age of patients was 62±75 years, 31,5% were men. Patients are divided into active monitoring and control groups. Weekly sms and e-mail messages with prevention information were sent to patients of the active monitoring group. General practitioners receive a course of training seminars on the features of follow-up observation of patients with AH. After 12 months (±3,2), the patients had repeated examination. We conducted pharmacoeconomic analysis of the intervention.

Results. The results of our study showed that the total cost of the disease with active follow-up of patients with AH decreases, which mainly occurs due to indirect expenses. Weekly sms and e-mail notification of patients in combination with educational seminars for general practitioners and cardiologists leads to a change in the structure of expenses for the treatment of patients with AH. We noticed reducing the cost of inpatient treatment, emergency calls, and a decrease in indirect expenses. On the other hand, there is a redistribution of funds spent on pharmacotherapy and cases of outpatient visits. Such redistribution, combined with a decrease in the total cost of the disease, leads to savings in the resources of the health care system and allows an additional 231 patients to be treated within 12 months.

Conclusion. The proposed model of active follow-up is economically viable, both by reducing the total cost of the disease, and by redistributing funds towards using pharmacotherapy and outpatient visits, which is the most rational in the treatment of AH.
The results of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in the surgical treatment of coronary artery disease with severe lesion of vessels
Authors: Fomichev A. V. , Chernyavsky A. M. , Gulyaeva K. K. , Poveshchenko O. V. , Lykov A. P. , Kareva Yu. E. , Minin S. M. , Nikitin N. A.
Published: February 2019

Aim. To assess safety and efficacy of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in surgery for coronary artery disease (CAD).

Materials and methods. Eighty patients with CAD with diffuse and (or) distal lesions of the right coronary artery were randomly assigned to two groups: patients of group 1 (n=40) underwent coronary bypass surgery, implantation of autologous bone marrow cells treated with erythropoietin into the lower wall of the left ventricle, patients of group 2 (control group, n=40) underwent bypass surgery of the left coronary artery. Evaluation of the clinical status, perfusion and contractility of the myocardium was performed initially, 6 and 12 months after surgery.

Results. Six months after the operation, we found more pronounced decrease of functional class (FC) of angina and improvement in the 6-min walk distance in the main group compared with the control group.

Twelve months after surgery, the severity of angina remained at the same level in both groups. In the control group, 45,2% of patients had FC I, 52,3% of patients did not have angina. In both groups, angina return was detected in 1 patient (FC III). According to the results of two-step myocardial scintigraphy with Technetril (Tc99), 6 months after surgery, a significant improvement in myocardial perfusion was observed. In the control group, after 6 months, no significant dynamics of perfusion of the lower wall of the left ventricle was detected.

Twelve months after the surgical treatment of the right coronary artery in patients from the group 1 revealed a decrease in the stress defect and the stable perfusion defect. In patients from the control only a significant stress defect was found to decrease.

Conclusion. The study demonstrated decrease of FCs, significant improvement in perfusion, functional state of the myocardium and 6-min walk distance in patients of group 1.
The state of the main arteries, vascular age in patients with arterial hypertension and obesity: the role of leptin and adiponectin
Authors: Statsenko M. E. , Derevyanchenko M. V.
Published: February 2019

Aim.To study the state of the main arteries and vascular age in conjunction with the level of leptin and adiponectin in patients with arterial hypertension (AH) and obesity.

Material and methods. One hundred and twenty patients with AH stage II aged from 45 to 65 years were divided into 3 groups depending on body mass index (BMI). Group 1 was represented by patients with AH and normal BMI, the 2 group was represented by patients with AH and excessive BMI, the 3 group was represented by patients with AH in combination with obesity. A standard clinical examination was performed, the stiffness of the vascular wall was measured by measuring the pulse wave velocity (PWV) of the muscle and elastic vessels (PWVe), vascular age was calculated, and the laboratory markers of obesity were determined.

Results.High percentage of visceral obesity was observed: 20,0% among people with normal BMI, 64,4% among overweight people and 100% among people with obesity (differences between 1 and 2, 1 and 3, 2 and 3 groups are reliable). A statistically significant increase in PWVe was detected in patients with AH and obesity in comparison with patients with AH and normal body weight (9,8 [8,5; 11,3] vs 8,0 [79; 8,1] m/s). Vascular age was higher in patients with AH and overweight or obesity compared with patients with AH and normal weight (670 [60,0; 76,0], 68,0 [60,0; 72,0] vs 58,0 [57,0; 60,0] years, respectively). A statistically significant increase in the concentration of leptin (6,9 [4,5; 15,1] vs 19,0 [74; 42,7] vs 53,8 [38,4; 75,8] ng/ml) was detected, as well as a decrease in adiponectin concentration from the 1 to the 3 group (44,9 [36,6; 55,8] vs 16,5 [12,5; 24,7] vs 18,6 [15,3; 22,4] ng/ml, respectively).

Correlation analysis revealed the presence of highly reliable relationships between the parameters of rigidity of the main arteries and laboratory markers of obesity.

Conclusion.The results indicated a negative effect of hyperleptinemia and hypoadiponectinemia on the elasticity of the vascular wall of the main arteries and the vascular age in hypertensive patients with its combination with overweight or obesity.
Effect of mineral admixtures on the properties of grouting materials made from a ternary complex system
Authors: Li Xianjun , Hao Jianying , Zhang Qiang
Published: February 2019

Novel research on the preparation of grouting materials with a high volume of mineral admixtures is presented. The grouting materials were made from a ternary complex system containing sulfoaluminate cement, aluminate cement and gypsum. The maximum contents of fly ash (FA) and ultrafine slag (UFS) in the grouting materials only containing FA or UFS were 17 wt% and 23 wt%, respectively. It was found that the incorporation of both FA and UFS greatly improved the properties of the grouts, mainly due to their composite compensation effect. The grouts containing UFS and FA in the weight ratio of 1:5, replacing 40% of the cementitious materials, showed high fluidity and the initial and 30 min fluidity values were the same (320 mm). The compressive strength at 3 d and 28 d reached 56·5 MPa and 76·4 MPa, respectively.
Effect of the surface treatment and hole size of pure titanium mesh on new bone formation
Authors: Shi Hong-Bing , Jang Yong-Seok , Nguyen Thuy-Duong Thi , Oh Tae-Ju , Han A-Lum , Lee Min-Ho , Ko Seung-O , Bae Tae-Sung
Published: February 2019

The purpose of this study is to investigate the effect of surface modification and hole size of pure titanium (Ti) mesh on the enhancement of bioactivity and new bone formation for the dental application of guided bone regeneration. Three types of titanium meshes with different hole sizes and distributions were used for surface treatments, which were anodization, silicate pretreatment, cyclic precalcification and heat treatment. Improvement of bioactivity as a result of the surface modifications and the tendency to new bone regeneration by the different designs of titanium meshes were identified through an immersion test in simulated body fluid and an in vivo test using the rat calvarial defect model, respectively. It was confirmed that the bioactivity of the titanium mesh was enhanced through the formation of multiple layers by anodization and precalcification treatments at the initial stage after implantation of the titanium mesh, and the hole size and distribution of the titanium mesh affected the new bone formation in the bone defect with implantation period differently.
Effect of geocell-reinforced sand base on bearing capacity of twin circular footings
Authors: Fazeli Dehkordi P. , Ghazavi M. , Ganjian N , Karim U. F. A.
Published: February 2019

The presence of a rigid layer underlying a soil bed layer supporting twin footings affects the footing bearing capacity and settlement. In this study, the bearing capacity and settlement of twin large-scale circular footings on unreinforced and geocell-reinforced sand layers with various thicknesses are investigated. The role of layer thickness, distance between two adjacent footings, and footing diameter indicates that the rigid base substantially influences the footing bearing pressure, settlement and tilt. The results show that the maximum bearing capacity is achieved when two footings are in contact and the rigid base is at shallow depth. The influence of the footing interference on settlement and tilting of closely spaced footings at a given load decreases with decreasing depth of rigid base and reinforcing the sand with geocells. This is observed for rigid bases located at less than about 2B, where B is the footing diameter.
A lower-bound formulation for unsaturated soils
Authors: Yuan Shuai , Du Jingna
Published: February 2019

A lower-bound formulation is proposed for consistent stability analysis of saturated and unsaturated soils with the suction stress-based effective stress employed to represent the shearing strength variation caused by matric suction. All constraints are expressed in terms of the effective stress. The body and surface forces induced by the suction stress are established and their effect on the equilibrium of unsaturated soils is studied in detail. Numerical solutions of the formulation are obtained by utilising linear triangular finite elements in combination with the second-order cone programming. Some numerical tests are given, and the lower-bound solutions are compared with the experimental data, the field measurements and the results of other methods. Close agreement is seen in all cases and the bounding property of the upper- and lower-bound formulations is guaranteed. The impact of the suction stress and the hydraulic state on the stability of some unsaturated earth structures is discussed.
Advantages of bus stop skipping and holding control in reducing schedule deviation
Authors: Zhang Hu , Liang Shidong , Zhao Shuzhi , Shang Qiang
Published: February 2019

In general, buses do not always operate in accordance with the set schedule in the modern-day transit system, mainly due to the randomness of passenger demand and running times. The failure to run on schedule deteriorates the quality of transit services. This paper proposes a real-time hybrid control strategy that is designed to shorten the passenger's waiting time caused by large schedule deviations, which can improve quality of transit services. Schedule deviations of a bus route are evaluated in order to judge whether the hybrid control strategy should be implemented or not. The proposed strategy includes skipping and holding actions, which are intended to allow buses to serve stops with high demand. Besides, to ensure the accuracy of schedule deviations, the controlled bus is followed by a non-controlled bus that provides schedule deviation data. The selection of appropriate skipping stops can be determined by maximising the benefits of a hybrid control strategy. Meanwhile, the control strategy is tested on a bus route. The threshold for implementing the control strategy is determined. Tests in this study prove the validity of the control strategy.
Implementation of building information modelling standards for the Shanghai Metro, China
Authors: Lai Huahui , Deng Xueyuan , Chen Hong , Shi Pingwang
Published: February 2019

In recent years, a large number of metro systems have been built in Chinese cities, this is especially true in Shanghai. As an emerging information management technology, building information modelling (BIM) has been introduced in the metro projects. However, very few data models of the completed metro projects conform to a uniform BIM standard. In fact, the existing deliverable models of different metro projects vary from each other widely in form as well as in contents. It becomes extremely difficult for participants to use these models for applications to new tasks or other related projects. Therefore a BIM standard framework was proposed for efficient BIM application, in particular for the Shanghai Metro system. The proposed framework includes information standard, modelling guideline, application standard and delivery standard. To ensure diverse BIM applications under these standards, associated tools were developed in the Shanghai Metro system: (a) a BIM object library for information standard, (b) rule-based checking tools for checking models according to modelling guideline and delivery standard and (c) a collaborative platform for BIM applications within application standard. The proposed standards and tools have been widely used in the Shanghai Metro system, and facilitated the standardisation and integration of BIM implementation on the metro.
Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts
Authors: Ishikawa Yasunobu , Fedeles Sorin , Marlier Arnaud , Zhang Chao , Gallagher Anna-Rachel , Lee Ann-Hwee , Somlo Stefan
Published: February 2019

Significance Statement

CKD of various etiologies manifests with declining kidney function in the setting of progressive interstitial inflammation, with increased myofibroblasts and collagen deposition. In this study, the authors developed a novel genetic model, demonstrating that impairment of protein homeostatic mechanisms in the endoplasmic reticulum of collecting duct cells is sufficient to produce interstitial inflammation, fibrosis, and impaired kidney function. In this model, genes encoding both Sec63, a resident protein in the endoplasmic reticulum membrane, and Xbp1, a transcription factor that is central to the unfolded protein response, were inactivated in the collecting ducts of neonatal mice. The result was progressive macrophage and myofibroblast expansion within 5 weeks and significant progressive kidney dysfunction thereafter. The Sec63-Xbp1 collecting duct knockout mouse offers a novel genetic model for studying chronic tubulointerstitial kidney injury.

Background

SEC63 encodes a resident protein in the endoplasmic reticulum membrane that, when mutated, causes human autosomal dominant polycystic liver disease. Selective inactivation of Sec63 in all distal nephron segments in embryonic mouse kidney results in polycystin-1–mediated polycystic kidney disease (PKD). It also activates the Ire1α-Xbp1 branch of the unfolded protein response, producing Xbp1s, the active transcription factor promoting expression of specific genes to alleviate endoplasmic reticulum stress. Simultaneous inactivation of Xbp1 and Sec63 worsens PKD in this model.

Methods

We explored the renal effects of postnatal inactivation of Sec63 alone or with concomitant inactivation of Xbp1 or Ire1α, specifically in the collecting ducts of neonatal mice.

Results

The later onset of inactivation of Sec63 restricted to the collecting duct does not result in overt activation of the Ire1α-Xbp1 pathway or cause polycystin-1–dependent PKD. Inactivating Sec63 along with either Xbp1 or Ire1α in this model causes interstitial inflammation and associated fibrosis with decline in kidney function over several months. Re-expression of XBP1s in vivo completely rescues the chronic kidney injury observed after inactivation of Sec63 with either Xbp1 or Ire1α.

Conclusions

In the absence of Sec63, basal levels of Xbp1s activity in collecting ducts is both necessary and sufficient to maintain proteostasis (protein homeostasis) and protect against inflammation, myofibroblast activation, and kidney functional decline. The Sec63-Xbp1 double knockout mouse offers a novel genetic model of chronic tubulointerstitial kidney injury, using collecting duct proteostasis defects as a platform for discovery of signals that may underlie CKD of disparate etiologies.
ВЛИЯНИЕ ПРИМЕСИ L,α-АЛАНИНА НА СПОНТАННУЮ ЭВОЛЮЦИЮ ДОМЕННОЙ СТРУКТУРЫ ТРИГЛИЦИНСУЛЬФАТА ВБЛИЗИ ТОЧКИ КЮРИ
Authors: Golitsyna Olga M. , Drozhdin Sergey N. , Lesnikova Valeriya O.
Published: February 2019

Методом атомной силовой микроскопии в режиме пьезоотклика изучена эволюция неравновесной доменной структуры кристаллов чистого триглицинсульфата (ТГС) и с примесью  L,α-аланина (АТГС) вблизи температуры фазового перехода ТС в температурном интервале ΔТС = ТС−Т = 1 К. В обоих кристаллах экспоненциально уменьшаются со временем  общее число доменов N и полный периметр доменных границ L, диэлектрическая проницаемость ε,  измеренная в слабом переменном электрическом поле. Изрезанность доменных границ в кристалле АТГС сохраняется с течением времени, приводя к росту значений среднего периметра домена  L / N. Средняя скорость спонтанного бокового движения доменных границ в кристалле АТГС меньше чем в ТГС из-за демпфирующего действия дефектов. Вблизи ТС оба кристалла являются открытыми системами с неконсервативным параметром порядка, и развитие доменной структуры происходит с изменением поверхностного заряда. При удалении от ТС состояние с сохраняющимся параметром порядка  достигается быстрее в дефектном кристалле АТГС.
КРИСТАЛЛИЗАЦИЯ КВАЗИБИНАРНОЙ ЭВТЕКТИКИ bnss-tss В СИСТЕМЕ Cu-Fe-Ni-S
Authors: Sinyova Svetlana I. , Kosyakov Victor I. , Sinyakova Elena F. , Novoghilova Olga S.
Published: February 2019

Исследование посвящено изучению процессов зональной кристаллизации в четырехкомпонентной системе Cu-Fe-Ni-S, являющейся базовой при формировании медно-никелевых сульфидных руд. Образец исходного состава (мол. %): Cu = 17.19, Fe = 19.05, Ni = 19.66, S = 44.10 синтезирован с применением метода квазиравновесной направленной кристаллизации. Результаты микроскопического исследования показали, что полученный слиток образован из 6 зон с разным фазовым и химическим составом. Основная часть слитка представлена зоной IV. Образцы, вырезанные из этой зоны, исследовались методами дифференциального термического анализа (ДТА), растровой электронной микроскопии (СЭМ) и рентгено-спектрального микроанализа (РСМА).  Микроскопические исследования позволили предположить, что слиток состоит из твердых растворов tss и bnss, но при дальнейшем охлаждении tss разложился на дочерние фазы. Однако эти данные можно трактовать и как кристаллизацию четверной эвтектики. Результаты ДТА исследования образцов позволили измерить температуры фазовых эффектов и однозначно установить образование бинарной эвтектики bnss-tss. Температура бинарной эвтектики (L → tss + bnss) составляет 578±1 °С (851±1 K). Температуры ликвидуса незначительно повышаются от 857±2 °С до 862±2 °С (1130±2 K - 1135±2 K). Указанное изменение объясняется небольшими изменениями состава исследуемых образцов. Полученные результаты подтвердили адекватность и согласованной предложенной методики, сочетающей методы направленной кристаллизации, дифференциального термического анализа, растровой электронной микроскопии и рентгеноспектрального микроанализа при исследовании фазовых равновесий в многокомпонентных системах.

 

Исследование выполнено в рамках госзадания (проект 0330-2016-0001) и при частичной финансовой поддержке комплексной программы фундаментальных научных исследований СО РАН II.1. № 303.
Cloning Leishmania by limit dilution v1
Authors: Lima Ana
Published: February 2019

This protocol was used to cloning Leishmania parasites aimed population study. The original protocol was described by Handman et al.(1983) and used limit dilution to clone the parasites. The present study performed some protocol modifications to adopt to different aims. It was needed to favor cutaneous Leishamnia (Viannia) subgenus growth. Thus, it was used Schneider medium (Sigma; St. Louise, MO, U.S.A.) with final 1% antibiotic concentrains and 10% fetal bovine serum. It is important to elucidat that this method was fast and efficient to obtain parasites clones .
SNP- CAPS analysis v1
Authors: Lima Ana
Published: February 2019

The possibility of Leishmania to perform genetic exchange has been demonstrated experimentally and registration of hybrid organisms has grown increasingly in the literature. In this study was performed a molecular confirmation of seven putative hybrid strains of Leishmania (V.) guyanensis / L. (V.) shawi involved in human cases of American Cutaneous Leishmaniasis in the Amazon region of Pará-Brazil. The Amazon region is an important endemic zone and presents a complex ecoepidemiological scenario given the diversity of species of parasites, hosts and existing reservoirs that circulate in the area. These characteristics favor the overlap of niches and the appearance of hybrid parasites.The single-nucleotide polymorphism genotyping/cleaved amplified polymorphic site (SNP-CAPS) analysis allows a qualitative analysis of the ploidy of organisms or even the proportion of different alleles in the same gene locus.In the present work was performed the SNP-CAPS assay adapted from the application of Akopyants et.al. (2009). The genomic structure of the leishmania genus is the mosaic model of aneuploidy. Through the SNP-CAPS assay one can infer polyploidy of the chromosome and if one of the parental species contributes with a greater number of alleles. A PCR reaction targeting sequences of the heat shock protein was performed. The PCR products were purified and then quantified.In this assay cleavage was performed starting from the same PCR product concentration among the hybrids and parental strains as well as the mix of amplicons of the parent species in different proportions. The single-nucleotide polymorphism genotyping / cleaved amplified polymorphic site (SNP-CAPS) analysis suggested a higher contribution from a determined parental species.
Bovine satellite cell Pax7 ICC v1
Authors: Stout Andrew , Rubio Natalie
Published: February 2019

Staining primary bovine satellite cells for Pax7, a common marker of satellite cells and myogenic potential. Protocol developed for https://www.thermofisher.com/antibody/product/PAX7-Antibody-Polyclonal/PA5-68506 (Thermo Fisher Pax7 antibody PA5-68506; rabbit IgG anti-Pax7)
Dissection and fixation of murine colonic tissue for myenteric plexus visualization v1
Authors: Heredia Dante , Smith Terence
Published: February 2019

Protocol for harvest of colonic intestinal tissue, with the intent of imaging the myenteric plexus.
Elements of Book Content: Features of Design and Influence on a Reader (Consumer)
Authors: Bidun Anna
Published: February 2019

The objective of the study was to find out the influence of book content elements on the target audience’s primary impression about the publication and their reading reactions. Methodology: The applicative base of the problem research are the results of a survey, which was made within reading audience (N = 600), publishers (N = 100), writers (N = 100) and librarians (N = 100) during May 30 – June 17 in 2018. The results of the survey were processed by sorting, classification, analysis and data comparison. The goals were to find out the main features of understanding the book content by the subjects of its creation and readers, to retrace the patterns of publishing preparation of book content elements, and the interdependence between the book’s perception and its design-conception. That is why different survey forms were used for the highlighted groups of respondents. The results. Publishers tend to overrate the influence of design-conception on reader’s choice. The primary impression and reactions about the publication correlate with the age and sex of the potential reader. Genre, title and author’s name have a key importance for readers, that is what writers also agree with. The title has the strongest influence on the teenager audience (under 16), and the weakest – on the audience at the age of 17–24. Author’s name has an essential value for the readers older than 45 years old, and the least – for teenagers under 16. Apart from author’s name and the book’s price, the most important is the title (for women) and the genre (for men). The book’s success depends on the efficiency of media field, built around the publication. Author’s status in the information field correlates with the interest regarding his next publications, thus forms its primary image, “semantic image”, even the image of publications, which are not completed.