bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of decoupling parameters on maximum allowable mass of anisotropic stellar structure constructed by mass constraint approach in f(Q)-gravity
Authors: Maurya S. K. , Aziz Abdul , Singh Ksh. Newton , Das Amit , Myrzakulov Kairat , Ray Saibal
Published: March 2024

In the present article anisotropic solutions with vanishing complexity in the framework of f(Q) gravity are generated. At first, the field equations in f(Q)-gravity are gravitationally decoupled where the isotropic fluid component corresponds to Vlasenko–Pronin space-time. Then, with a new source, the complete geometric deformation is supplemented to an isotropic component, and the related deformation function is derived by the method known as mimicking of mass constraints. Furthermore, the generated anisotropic solution prevails all the physical tests along with the stability analysis with respect to the decoupling parameter as well as the f(Q) gravity parameter and it accomplishes the physical representation of observational constraint related to stars, namely, SMC X-1, 2 S 0921-630, PSR J0437-4715, Vela X-1, PSR J1748-2021B which are reflected in Mass–Radius curves. Hence, the study comes out to be worthy of the fact that the f(Q) gravity parameter directly influences the maximum mass of a compact stellar configuration for the fixed decoupling parameter in the context of gravitational decoupling where it predicts the star PSR J1748-2021B having highest mass 2.74 $$M_{\odot }$$

M
⊙

. It is noted that when the decoupling parameter ($$\alpha $$
α
) increases, the central value of the adiabatic index value also increases, while the reverse situation occurs when the f(Q)-parameter ($$\beta _1$$

β
1

) gets increased. This implies that both the parameters $$\alpha $$
α
and $$\beta _1$$

β
1

have the overall controlling power on the stability of the model.
Elastic, thermophysical and ultrasonic investigation of tin monochalcogenides
Authors: Singh Anurag , Tripathi Sudhanshu , Singh Devraj
Published: March 2024

This work explores the investigation of tin monochalcogenides i.e. SnX (X: S, Se, Te) at room temperature (300[Formula: see text]K). The mechanical, thermophysical and ultrasonic properties of SnX (X: S, Se, Te) have been evaluated using the computed values of second- and third-order elastic constants (SOECs and TOECs). The SOECs and TOECs have been obtained using Born–Mayer potential model at 0[Formula: see text]K and 300[Formula: see text]K. The brittleness behavior of tin monochalcogenides is detected by Pugh’s ratio. It is observed that phonon–phonon interaction mechanism is dominant in tin monochalcogenides leading to high ultrasonic attenuation. The obtained temperature dependence behavior of tin monochalcogenides is validated via comparison with available works of literature data in previous works done experimentally as well as theoretically by others.
Four-party quantum secure direct communication based on hyperentangled bell states
Authors: Guo Ran , Zhou Ri-Gui , Zhang Xiao-Xue
Published: March 2024

Quantum Secure Direct Communication (QSDC) is a promising approach for secure information exchange. This paper proposes an efficient and secure four-party QSDC scheme utilizing hyperentangled Bell states in the polarization degree of freedom, the first longitudinal momentum degree of freedom and the second longitudinal momentum degree of freedom. The four participants can perform different unitary operations to independently encode their secret messages onto photons in three degrees of freedom, subsequently transmitting them directly through the quantum channel. In this proposed protocol, each degree of freedom of the photon can effectively carry two bits of information. Each round of transmission by a photon enables the four legitimate participants to obtain six classical bits of information. Notably, when compared to other photons based single-degree-of-freedom QSDC network protocols, the capacity of proposed QSDC protocol is tripled. Therefore, it significantly enhances the information transmission capability. Furthermore, comprehensive security analysis shows that our QSDC network protocol can withstand various attacks from external eavesdroppers.
Deep Coupling Network for Multivariate Time Series Forecasting
Authors: Yi Kun , Zhang Qi , He Hui , Shi Kaize , Hu Liang , An Ning , Niu Zhendong
Published: March 2024

Multivariate time series (MTS) forecasting is crucial in many real-world applications. To achieve accurate MTS forecasting, it is essential to simultaneously consider both intra- and inter-series relationships among time series data. However, previous work has typically modeled intra- and inter-series relationships separately and has disregarded multi-order interactions present within and between time series data, which can seriously degrade forecasting accuracy. In this article, we reexamine intra- and inter-series relationships from the perspective of mutual information and accordingly construct a comprehensive relationship learning mechanism tailored to simultaneously capture the intricate multi-order intra- and inter-series couplings. Based on the mechanism, we propose a novel deep coupling network for MTS forecasting, named DeepCN, which consists of a coupling mechanism dedicated to explicitly exploring the multi-order intra- and inter-series relationships among time series data concurrently, a coupled variable representation module aimed at encoding diverse variable patterns, and an inference module facilitating predictions through one forward step. Extensive experiments conducted on seven real-world datasets demonstrate that our proposed DeepCN achieves superior performance compared with the state-of-the-art baselines.
In Situ Heterojunction-based PEC Sensor Coupled with LSPR for Sensitive Detection of Aflatoxin B1
Authors: Liu Xianliang , Liu Yuanyuan , Wang Yanhui , Chen Xiaoxia , Feng Xinyi , Wang Shujun , Li Yueyuan , Zhang Yuzhu , Chen Lei , Liu Qing
Published: March 2024

To enhance the performance of photoelectrochemical (PEC) sensors, heterojunction construction is a workable technique. However, the interface defects inside the structure are often ignored. In this work, an innovative photoelectrochemical (PEC) sensor based on a “turn-off” PEC model was constructed using the synergistic effects of in situ growing heterojunction and local surface plasmon resonance (LSPR) to detect Aflatoxin B1 (AFB1) instantly. In situ heterojunctions were constructed based on bismuth-based perovskite, and the internal electric field spontaneously established during the growth process can effectively compensate for the interfacial defects and promote the separation and transfer of e−/h+ pairs. Moreover, the gold nanoparticles (Au NPs) LSPR effect can improve PEC performance by enhancing the light trapping ability of the material. The PEC sensor’s detecting area for AFB1 analysis is 10.0 fg/ml-100 ng ml−1, and the detection limit is 4.34 fg ml−1. Good stability, reproducibility, and selectivity underscore the sensor’s suitability for meeting the requirements of food quality monitoring.
Sparsentan ameliorates glomerular hypercellularity and inflammatory-gene networks induced by IgA1-IgG immune complexes in a mouse model of IgA nephropathy
Authors: Reily Colin , Moldoveanu Zina , Pramparo Tiziano , Hall Stacy , Huang Zhi-Qiang , Rice Terri , Novak Lea , Komers Radko , Jenkinson Celia P. , Novak Jan
Published: March 2024

The mechanisms by which deposited IgA1 immune complexes cause kidney injury during early phases of IgA nephropathy are poorly understood. We used an animal model we recently developed that involves IgA1-IgG immune complex injections and determined pathways related to the induced mesangioproliferative changes. Treatment with sparsentan, a dual inhibitor of endothelin type A and angiotensin II type 1 receptors, ameliorated the induced mesangioproliferative changes and the associated alterations in the expression of inflammatory genes and networks.
Effect of Fungal and Fungal-Bacterial Tempe-Type Fermentation on the Bioactive Potential of Grass Pea Seeds and Flaxseed Oil Cake Mix
Authors: Stodolak Bożena , Grabacka Maja , Starzyńska-Janiszewska Anna , Duliński Robert
Published: March 2024

Tempe is an Indonesian food product traditionally obtained from soybeans through solid-state fermentation with Rhizopus. A variety of substrates can be processed into tempe in the presence of other microorganisms. In this study, grass pea seeds with the addition of flaxseed oil cake (20% w/w) were either fermented using individual mould strains—Rhizopus oryzae, R. oligosporus, and Mucor indicus—or cofermented with the moulds and Lactiplantibacillus plantarum. In the obtained products, the content of dietary fibre, B group vitamins, and the level of peptides and antioxidant potential in aqueous extracts were measured. Moreover, peptides, angiotensin I convertase inhibitor, and antioxidant activity were determined after in vitro digestion. The effect of digestates on the differentiation of enterocytes was also investigated. Fermentation generally resulted in a decrease in the dietary fibre, especially the insoluble fraction (30-50%). The product obtained with R. oryzae was the best source of riboflavin and thiamine among all tested. The fermentation process promoted the accumulation of water-soluble peptides and antioxidant compounds. After in vitro digestion, the largest amount of antioxidant and antiradical compounds was released from tempe obtained with R. oryzae. However, the enrichment of the products with antioxidants resulting from solid-state fermentation did not simply translate into an improvement in antioxidant potential after digestion. Generally, fermentation carried out in the presence of L. plantarum brought positive effects only in the case of R. oligosporus DSM 1964. Digestion products obtained from R. oryzae tempe had a positive effect on the viability of Caco-2 cells differentiated into enterocytes. Interestingly, a higher activity of differentiation markers (alkaline phosphatase and sucrase-isomaltase) was observed under the influence of digestate of R. oryzae and L. plantarum tempe.
Estimation of the Age of the Kashubian-Specific Pathogenic NPHS2 Variant Responsible for Hereditary Steroid-Resistant Nephrotic Syndrome Points to Its Recent Local Origin
Authors: Jankowski M. , Daca-Roszak P. , Bałasz-Chmielewska I. , Ustaszewski A. , Żurowska A. , Lipska-Ziętkiewicz B. S. , Ziętkiewicz E.
Published: March 2024

Steroid-resistant nephrotic syndrome (SRNS) is a highly heterogenic kidney disorder resulting from genetic abnormalities or immune system dysfunction affecting the establishment and maintenance of the glomerular filtration barrier. The most common cause of genetic SRNS is biallelic pathogenic variants in NPHS2 gene, especially in individuals with an infantile or childhood onset. The type of the NPHS2 defect implies the course of the disease and the stage of its onset and differs across populations. In a cohort of Polish patients with SRNS, a unique profile of the disease-related NPHS2 variants was identified in patients from northern Poland inhabited by Kashubs, a minority West-Slavic ethnic group known for a local increase of the frequency of several pathogenic variants. Among Kashubian families, the compound heterozygotes c.686G>A/c.1032delT and a single c.1032delT homozygote were the only underlying cause of SRNS. The restricted, Kashubian-only pattern of c.1032delT occurrence, suggesting the founder effect, prompted us to conduct a detailed analysis of its haplotype background to estimate the age of the c.1032delT origin. Eight Kashubian SRNS families were genotyped using the Infinium Global Screening Array-24. The haplotype background analysis was performed using an in-house pipeline designed to solve the phase of the heterozygous genotype data. The age of the c.1032delT mutation was calculated using the gamma method based on the genetic length of ancestral haplotypes shared between two or more individuals carrying this variant. The results of our study indicated a very recent origin of the c.1032delT mutation (~240 years). Genetic screening performed in the general Polish population control corroborates the assumption that the mutation occurred on the specific Kashubian haplotype background. The identification of ancestry-specific Kashubian pathogenic variant can help to develop effective screening and diagnostic strategies as a part of personalized medicine approach in the region.
Supplementary Data from Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma
Authors: Rohila Deepak , Park In Hwan , Pham Timothy V. , Weitz Jonathan , Hurtado de Mendoza Tatiana , Madheswaran Suresh , Ishfaq Mehreen , Beaman Cooper , Tapia Elisabette , Sun Siming , Patel Jay , Tamayo Pablo , Lowy Andrew M. , Joshi Shweta
Published: March 2024

Supplementary table
Supplementary Figure 3 from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

Supplementary Figure 3 shows expression of VEGF proteins.
Supplementary Figure 1 from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

Supplementary Figure 1 shows T cell-based immune phenotypes and spatial analysis of immune cell populations
FIGURE 6 from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

VEGF-A expression by in vitro polarized TAMs. A, Healthy donor monocytes were differentiated into macrophages using GMCSF and exposed to different culture conditions: medium alone (monocyte-derived macrophage) or A-431 supernatant (in vitro polarized TAM). Immunofluorescent staining was performed on day 5 and compared with A-431 cells. Cells were stained with anti-VEGF-A (clone VG-1; cytoplasma, green), PKH26 (cell membrane, red), and Hoechst 34580 (cell nucleus, blue). Representative overlay figures are depicted (32x magnification); white scale bar length 200 µm. B, Macrophages were generated as in A and intracellular VEGF-A expression was determined by flow cytometry (anti-VEGF-A clone 23410) on day 5. Data combine results from two independently analyzed individuals. Data are given as d-gMFIs. Individual datapoints, shown as dots, overlap summary statistics barplots (mean ± SEM). Significance analysis by two-sided Student t test. C, Macrophages were generated as in A, and in vitro polarized TAMs and A-431 cells were cultured alone (monoculture) or together (coculture with 2:1 ratio) in the presence of LPS. Intracellular VEGF-A expression was determined by flow cytometry using two anti-VEGF-A antibody clones as indicated after 24 hours of coculture following a 4-hour restimulation with Brefeldin A. For comparison between different cell types, specific cell populations of interest were identified on the basis of their expression of phenotypic markers (EpCAM for cancer cells, CD14 for macrophages), a negative control was included, and cocultured cells were normalized to VEGF expression of blood lymphocytes. Data combine results from three individuals and are given as d-gMFIs. Individual datapoints, shown as dots, overlap summary statistics boxplots with medians represented by horizontal center lines. Significance analysis by two-sided Student t test.
FIGURE 4 from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

CD163+ TAMs are associated with lymphogenesis. A, LVD and LVI were assessed in the stroma using D2-40–stained lymphatic endothelium. Intratumoral and stromal CD163 immunoreactivity was recorded as in Fig. 1B; data are presented as mean immunoreactivity normalized to tissue compartments in percent. CD163+ TAMs were categorized on the basis of high/low LVD and the presence/absence of LVI. Individual datapoints, shown as dots, overlap summary statistics boxplots with medians represented by horizontal center lines. Significance analysis by two-sided Mann–Whitney U test with Benjamini–Hochberg procedure. B, BVD and BVI were assessed in the stroma using CD31-stained vessels. Intratumoral and stromal CD163 immunoreactivity was recorded as in Fig. 1B; data are presented as mean immunoreactivity normalized to tissue compartments in percent. CD163+ TAMs were categorized on the basis of high/low BVD and the presence/absence of BVI. Individual datapoints, shown as dots, overlap summary statistics boxplots with medians represented by horizontal center lines. Significance analysis by two-sided Mann–Whitney U test with Benjamini–Hochberg procedure.
FIGURE 2 from Immune Profiling of Vulvar Squamous Cell Cancer Discovers a Macrophage-rich Subtype Associated with Poor Prognosis
Authors: Condic Mateja , Rohr Andrea , Riemann Soheila , Staerk Christian , Ayub Tiyasha H. , Doeser Anna , Zillinger Thomas , Merkelbach-Bruse Sabine , Buettner Reinhard , Barchet Winfried , Rudlowski Christian , Mustea Alexander , Kübler Kirsten
Published: March 2024

The TAMhigh immune cell cluster is associated with poor outcome. A, Heat map shows the distribution of immune cells (intratumoral and stromal combined). Immunoreactivity was recorded as in Fig. 1B. Unsupervised clustering of log2-transformed cell count data from 41 samples was performed using Euclidean distance. B, Kaplan–Meier plots depict OS and RFS of patients stratified by TAM clusters from A; significance analysis by log-rank test.
Associations of Digital Ulcers in Patients with Systemic Sclerosis: An 8-Year Retrospective Study
Authors: Chi Miaomiao , An Qi , Feng Xiuyuan , He Lan , Pan Ying
Published: March 2024

Introduction: This study aimed to investigate the associations of digital ulcers (DUs) in patients with systemic sclerosis (SSc). Methods: This retrospective study investigated the demographic characteristics, specific autoantibodies, organ involvement, and laboratory tests in patients with SSc from our hospital. Results: This study enrolled 144 patients with SSc. The DU+ group consisted of 15 (10.4%) patients. Patients with SSc having DUs have longer disease duration, higher fibrinogen, higher fibrin degradation product, and lower cholesterol. None of the patients used cholesterol-lowering drugs before onset of DUs. The study also demonstrated a higher prevalence of anti-dsDNA and anti-histone antibodies in patients with SSc with DUs. Anti-dsDNA antibody is a specific antibody for SLE with a specificity of 96–99%. A total of 86.1% (124/144) of patients suffered from diffuse cutaneous SSc, and 28.5% (41/144) of patients suffered from overlap syndrome. Conclusion: Our study indicated that patients with SSc with fibrinogen of >2.895 g/L (p = 0.043) and cholesterol of <3.340 mmol/L (p = 0.036), which is equal to 129.258 mg/dL, are at high risk of developing DUs.
Urothelial Cell Carcinoma of the Bladder and Urinary Bladder Rupture as a Rare Cause of Acute Peritonitis: A Case Report
Authors: Huang Johnson Da , Shao Emily Ximin , Ngoo Alexander , Tham Chui Ming , Rhee Handoo
Published: March 2024

Introduction: Urothelial carcinoma of the bladder causing spontaneous rupture of the bladder is an extremely rare condition with poor outcomes due to it being highly suggestive of advanced malignancy. Case Presentation: We present the case of a 74-year-old man who presented with non-specific signs and symptoms of abdominal pain and haematuria. Abdominal imaging was suggestive of a small bowel obstruction and a bowel perforation. At time of laparotomy, however, the patient was found to have metastatic urothelial carcinoma with peritoneal metastases. The patient unfortunately passed away 2 months following their initial presentation. Conclusion: Bladder perforation secondary to urothelial cancer is a rare pathology associated with poor prognosis. There are fewer than thirty cases reported in the literature, and it is often not considered during initial diagnostic workup of patients with abdominal sepsis in the context of bladder cancer. A high degree of suspicion for bladder rupture is recommended in patients with peritonism and urinary symptoms. Awareness of this condition will help facilitate prompt diagnosis and appropriate management.
A Comparison of Telencephalon Composition among Chickens, Junglefowl, and Wild Galliforms
Authors: Racicot Kelsey J. , Ham Jackson R. , Augustine Jacqueline K. , Henriksen Rie , Wright Dominic , Iwaniuk Andrew N.
Published: March 2024

Introduction: Domestication is the process of modifying animals for human benefit through selective breeding in captivity. One of the traits that often diverges is the size of the brain and its constituent regions; almost all domesticated species have relatively smaller brains and brain regions than their wild ancestors. Although the effects of domestication on the brain have been investigated across a range of both mammal and bird species, almost nothing is known about the neuroanatomical effects of domestication on the world’s most common bird: the chicken (Gallus gallus). Methods: We compared the quantitative neuroanatomy of the telencephalon of white leghorn chickens with red junglefowl, their wild counterpart, and several wild galliform species. We focused specifically on the telencephalon because telencephalic regions typically exhibit the biggest differences in size in domesticate-wild comparisons. Results: Relative telencephalon size was larger in chickens than in junglefowl and ruffed grouse (Bonasa umbellus). The relative size of telencephalic regions did not differ between chickens and junglefowl, but did differ in comparison with ruffed grouse. Ruffed grouse had larger hyperpallia and smaller entopallial, nidopallial, and striatal volumes than chickens and junglefowl. Multivariate analyses that included an additional three wild grouse species corroborated these findings: chicken and junglefowl have relatively larger nidopallial and striatal volumes than grouse. Conversely, the mesopallial and hyperpallial volumes tended to be relatively smaller in chickens and junglefowl. Conclusion: From this suite of comparisons, we conclude that chickens do not follow a pattern of widespread decreases in telencephalic region sizes that is often viewed as typical of domestication. Instead, chickens have undergone a mosaic of changes with some regions increasing and others decreasing in size, and there are few differences between chickens and junglefowl.
Real-World Effectiveness of Omalizumab in Chronic Urticaria: A Clinical Observational Study
Authors: Zhang Fan , Liao Jiashun , Qian Yuan , Niu Xinyu , Wei Jia , Li Man , Guo Duyi , Zhu Peiqiu
Published: March 2024

Introduction: The purpose of this study was to assess the clinical effectiveness and safety profile of omalizumab as a therapeutic intervention for chronic urticaria (CU). Methods: From March 1, 2023, to September 30, 2023, data on a cohort comprising 96 patients with CU, who underwent treatment with omalizumab at our medical institution’s allergy clinic, were systematically compiled. Subsequent to the administration of omalizumab, the therapeutic efficacy was assessed utilizing the 7-day urticaria activity score and the urticaria control test. Results: Based on the statistical analysis, the mean duration of therapeutic intervention was 2.4 ± 1.3 months, with a corresponding mean cumulative dosage of 765 ± 450 mg. Of the subset of 42 patients with CU who were subjected to a follow-up period exceeding 3 months, it was observed that the treatment led to complete symptom remission, and no instances of recurrence were documented. Notably, there were statistically significant differences in the treatment duration and the cumulative dosage between patients who experienced co-morbid conditions and those who did not (p < 0.01, 95% CI: 0.280–1.326; p < 0.01, 95% CI: 0.597–2.997). Furthermore, there were significant differences in the treatment duration and cumulative dosage between patients in the combined allergic rhinitis group and those in the non-combined allergic rhinitis group (p < 0.01, 95% CI: 0.204–1.305; p = 0.01, 95% CI: 0.326–2.860). Conclusion: Omalizumab demonstrates efficacy in the management of CU among Chinese patients by exerting effective symptom control and facilitating the regression of skin lesions. The assessment of its therapeutic efficacy typically requires a 12-week treatment period. Moreover, the co-occurrence of CU with other allergic disorders serves as a pertinent consideration for the adjustment of omalizumab dosing regimens.
Neoadjuvant Chemotherapy in Non-Metastatic Eyelid Sebaceous Gland Carcinoma: A Report in 10 Cases
Authors: Kumar Nipun , Meel Rachna , Bakhshi Sameer , Pushpam Deepam , Pushker Neelam , Bajaj Mandeep Singh , Kashyap Seema , Sen Seema , Pathy Sushmita , Sharma Sanjay
Published: March 2024

Introduction: Eyelid sebaceous gland carcinoma (SGC) is an aggressive malignancy. Surgical excision is the standard treatment for non-metastatic eyelid SGC. This study aimed to evaluate treatment outcomes with use of neoadjuvant chemotherapy (NACT) and any change in ease/difficulty of surgical treatment in such cases. Methods: This was a prospective interventional study conducted over 24-month period. Histopathologically, confirmed cases without any systemic metastasis were included. Clinico-demographic details were collected for 30 patients. 10 patients received NACT using cisplatin and 5-FU. Tumour response was evaluated using RECIST criteria. An ease of surgery questionnaire was used to assess difficulty of surgical treatment before and after NACT. Results: Of the 30 patients evaluated for recruitment, 37% had recurrent SGC and 72% had advanced tumour stage. Ten patients were recruited for NACT. There was partial response in 80% and complete response in 10% cases. Tumour T category downstaging was seen in 50% of cases. While tumour dimensions/volume reduced substantially, surgical ease improved in only 40% cases. Conclusion: A significant proportion of SGC patients evaluated in our study presented with recurrent and/or advanced disease. NACT caused tumour regression in 90% of cases. However, surgical ease improvement was limited, pointing to a need for surgical modification in such cases. Corneal ulceration was noted in 2 cases with large tumours causing a complete mechanical ptosis. Overall, the study introduced an ease of surgery questionnaire and provided insights into benefits and challenges of using NACT for eyelid SGC management.
Planetarium pedagogy and technical learning experience: an investigation from instructional perspectives
Authors: Mohd Yusof Mohammad Mubarrak , Shaafi Nur Farha , Zaini Nur Atiqah Farzana
Published: March 2024

The research focused on the National Planetarium Kuala Lumpur’s education programs, investigating the types and target audiences. It examined the educational theories and strategies used, including multiple intelligence theory and cooperative learning. The study also explored the alignment of astrophysics in Pearson Edexcel International General Certificate of Secondary Education (IGCSE) Physics with the Planetarium’s programs. Document analysis and participant observation were employed. The results revealed two program types: on-site and online. The programs showed alignment with IGCSE Physics and utilized theories like social cognitive theory. The National Planetarium positively impacted students through multi-intelligence theory, sociocultural theory, experiential theory, and constructivism. Gamification and group activities enhanced the learning experience. The Planetarium’s ability to simulate astronomical events made it an effective medium for instructional science institutions. Overall, the study highlighted the diverse education programs of the National Planetarium Kuala Lumpur, their alignment with IGCSE Physics, and their positive impact on students’ personal, physical, and social contexts.
The flipped-classroom effect on vocational high school students’ learning outcomes
Authors: Herlambang Admaja Dwi , Ririn Ririn , Rachmadi Aditya
Published: March 2024

The flipped-classroom instructional model is considered suitable for teaching procedural knowledge. Apart from flipped-classroom, it turns out that another instructional model, namely direct instruction, is also designed to teach procedural knowledge. Therefore, this study aimed to examine differences in procedural knowledge learning outcomes between flipped-classroom and direct instruction learning models in the cognitive and psychomotor domains and to determine the effect of flipped-classroom on students’ procedural knowledge learning outcomes. This type of research is a true-experimental design with a randomized pre-test post-test control group design for the cognitive domain and a randomized post-test only control group design for the psychomotor domain. The research instrument used a written test (pre-test and post-test) for the cognitive domain and a performance assessment for the psychomotor domain. The flipped-classroom is better than direct instruction regarding procedural knowledge learning outcomes. Furthermore, flipped-classroom significantly affects the students’ procedural knowledge learning outcomes, both cognitive and psychomotor domains. The effect of flipped-classroom implementation on the psychomotor domain (t(50)=23.62; p<0.01; d=6.56) is greater than the impact of performance on the cognitive domain (t(50)=2.35; p<0.05; d=0.65).
Active learning pedagogical dimensions: discovering and bridging the pedagogical gaps
Authors: Leow Min Hui , Hassan Norshahida , Mohd Sharizal Sabrina Adia , Razak Rafiza Abdul
Published: March 2024

Current literatures of active learning widely address pedagogies/approaches and their outcomes, but it does not appear to be a pedagogical consensus regarding the active learning pedagogies/approaches. This situation makes it difficult to gauge the prevalence and practicability of active learning pedagogies/approaches in specific educational levels. This systematic review is aimed to find the consensus of active learning pedagogies/approaches applied in pre-school to tertiary education on the basis of constructivist philosophy and student-centered notion, determine the desirable pedagogical dimensions, discover pedagogical gaps, and offer attention for bridging the gaps. We located seven pedagogical dimensions from teachers’ perspectives of pedagogical features, in terms of pedagogies/approaches and theories/concepts, from 148 publications that were eligible for inclusion after filtered through PRISMA. The learning outcomes or evidence of effectiveness were determined across various pedagogies/approaches in relation to pedagogical dimensions’ manifestation. Content analysis was employed in this work to encode, categorize, and develop themes. As a result, this study highlights the pedagogical gaps between desirable pedagogical dimensions’ manifestation and actual pedagogy attainment at various educational levels and provides suggestion for bridging the gaps to ensure smooth pedagogical transition. The study may serve as a foundation for future active learning pedagogical designs and enrich student-centered learning initiatives.
Adaptation and validation the integration scale for Indonesian university students: academic and social
Authors: Dwiastuti Ike , Hendriani Wiwin , Andriani Fitri
Published: March 2024

Student integration is a student’s ability to integrate into the social and academic systems of the university. Integration of students has been shown to affect how well they do on campus, which helps them finish higher education. The integration scale (IS) measures integration ability that meets the principle of simplicity. The integration scale is formed of 16 items divided into five aspects and two factors. This study aimed to adapt and validate IS instruments for the Indonesian university student population. The research methods complied with the six-step procedures the International Test Commission set out. A total of 309 participants were undergraduate students. They were between 17 and 23 years old (mean=19.42, SD=1.11 years), with 247 females (79.94%) and 62 males (20.06%). The results of the confirmatory factor analysis revealed that a total of 16 items were valid and reliable. Three models that have acceptable fits were confirmed. The results demonstrate that the Indonesian integration scale measures undergraduate student integration with comparable precision to the original scale. This scale can identify students who require academic and social integration assistance and evaluate the institution’s role in academic development.
Awareness, acceptability, congruency, and attainability of an academic institution’s vision, mission, goals, and objectives
Authors: G. Niala Chriselda Saniata , Pascua Dahlee S.
Published: March 2024

The mandate of Isabela State University is to deliver higher learning in the arts, agriculture, natural sciences, technology, and specialized disciplines. Hence, the institution executes a strategic vision, mission, goals, and objectives (VMGO) to meet the expectations of its stakeholders. This research examined the degree of stakeholders’ awareness, acceptance and understanding of the Isabela State University, College of Business, Accountancy, and Public Administration’s (ISU-CBAPA) VMGO; its congruence with the educational approaches of the faculty and resources of the institution in delivering quality education; and whether the program goals and objectives of the business programs were attained. A quantitative descriptive research method was used. The results indicate that the respondents are generally highly aware of the ISU-CBAPA VMGO and its dissemination. The respondents perfectly understand and accept the ISU-CBAPA VMGO and highly perceive the extent of its congruence with academic strategies, practices, and activities. In addition, all respondents perceived that the ISU-CBAPA VMGO is being realized and favorably attained, despite the significant differences found. Recommendations include intensifying VMGO dissemination to external stakeholders, emphasizing VMGO commitments toward its realization, and emphasizing improvement on the students’ development of professional skills, research capabilities, and competencies, and their readiness for employment and/or managing a business.
The total contribution of the direct and indirect influence of servant leadership on innovative work behavior
Authors: Vhalery Rendika , Prasetyono Hendro , Ramdayana Ira Pratiwi , Salmin Salmin , Anggraini Widya Priska
Published: March 2024

This study aimed to determine the total contribution of servant leadership variables directly or indirectly to the innovative work behavior of high school teachers. The research respondents were 158 teachers from Jakarta Capital Special Region, Bogor Regency, Bekasi City, and Bandung Regency, Indonesia. Data analysis technique using path analysis. The results showed that the total direct and indirect contribution of servant leadership variables to innovative work behavior through knowledge sharing was 97.3%. The remaining 2.7% comes from variables not examined in this study. The implications of this research can be used by school principals and education policymakers at the national and regional levels to strengthen servant leadership to create knowledge sharing in strengthening the innovative work behavior of teachers in senior high schools.
Preserving the gotong royong character for Indonesian Gen-Z in the digital era
Authors: Murtadlo Muhamad , Albana Hasan , Helmy Muhammad Irfan , Libriyanti Yuyun , Izazy Nurul Qolbi , Saloom Gazi
Published: March 2024

Gotong royong is a significant character for Indonesian generation Z (Gen-Z), based on traditional values, to unite this multicultural nation. However, the rapid development of digital media has the potential to alter traditional values. Gen-Z has the ability to quickly adapt to this technology. However, there is a concern that the gotong royong character may decline with the rise of digital media. This research investigates the perception of Gen-Z towards the gotong royong character and explores the way to preserve this value. This is qualitative descriptive research, whose population is made up of 108 students from six excellent schools in three Indonesian cities with different religious backgrounds and educational systems. The results show that Gen-Z still considers the gotong royong value is important. However, they also acknowledge that it can be threatened by the advancement of digital technology. With this awareness, Gen-Z can explore ways to adopt digital technology to preserve this character value, such as utilizing digital learning in club study and digital fundraising. This research recommends optimizing the school institution to take a more active role in fostering character through online character-building learning.
The validity and reliability of professional learning community instruments in small schools peninsular Malaysia
Authors: Razali Mohd Norlizam Mohd , Hamid Aida Hanim A. , Alias Bity Salwana
Published: March 2024

A professional learning community (PLC) instrument was developed to determine the level of PLC practice in small schools in Peninsular Malaysia. This study was conducted in Perak and Negeri Sembilan to determine the instrument's reliability and validity. Exploratory factor analysis (EFA) and item reliability analysis were used to determine the questionnaire’s reliability and validity. Next, the average congruence percentage (ACP) is used to determine the reliability test between expert assessors. Experts approved the validity and reliability of the instrument before the EFA test was conducted. All five constructs have high-reliability index values between 0.86–0.95. Next, the EFA analysis shows five dimensions in the PLC instrument with factor loadings ranging from 0.61–0.84. The findings also show that the variance explained in the data is 68.99% with an Eigenvalue greater than 1. This result indicates that all items are received with high approval. In addition, a very high-reliability coefficient value, α=0.96. The results prove that this PLC instrument has high validity and reliability and can measure the level of PLC implementation practices in small schools in Peninsular Malaysia.
Naturally felt emotions, work engagement: the moderating role of perceived organizational support
Authors: Vinahapsari Cinthia Annisa , Ibrahim Hazril Izwar , Kimpah Jeniboy
Published: March 2024

The main purpose of this study is to investigate whether or not emotional labor strategy (i.e., naturally felt emotions) significantly predicts work engagement (i.e., vigor, dedication, absorption) among academicians in a higher education setting. It also evaluates the role of perceived organizational support (POS) as the moderating variable between naturally felt emotions (NFE) and work engagement. This study employs a survey questionnaire, and data collected from private universities in Central Java, Indonesia. To analyze the data and test the proposed model, the partial least squares structural equation modelling approach was employed. The findings demonstrate that: i) NFE are significantly and positively related to all work engagement dimensions; and ii) POS is proven insignificant to moderate the relationship between NFE and work engagement dimensions. The results of this study complement the literature by addressing associations between NFE and work-related outcomes (i.e., work engagement), especially in the Indonesian academic context. In addition, this study also confirms the insignificant role of POS which is based on norms of mutuality between the organization and employee. Finally, the study offers recommendations and conclusions to achieve long-term objectives for higher education institutions.
Enhancing teacher competence through collaborative worksheet development: an empirical investigation
Authors: Meilinda Meilinda , Putri Ratu Ilma Indra , Zulkardi Zulkardi , Inderawati Rita , Desnita Try
Published: March 2024

This study examined the efficacy of collaborative teaching using a projectbased learning (PjBL) worksheet on plastic waste and climate change. The research design followed a type-II development approach, with two distinct phases: exploration and development, and collaborative teaching. The study involved five science teachers, two lecturers, and 45 seventh-grade students in three limited field trials. The study found that collaborative teaching through worksheet development could increase science teachers’ professionalism, particularly in the collegial phase. Furthermore, the study developed a valid PjBL-based worksheet on plastic waste and climate change, aligning with the 2013 curriculum for science instruction in junior high school, involving three core competencies. The research design employed a lesson study framework, which allowed for a thorough exploration of the research topic, leading to the development of effective instructional material. The findings of this study have significant implications for science education in junior high school, particularly in promoting active learning and fostering a deeper understanding of complex environmental issues. Overall, the study highlights the importance of collaborative teaching and the potential of PjBL-based worksheets in enhancing teacher competence and developing relevant instructional materials that align with the curriculum.
Voices of first graders: exploratory study on starting school during post-pandemic period
Authors: Pranoto Yuli Kurniawati Sugiyo , Diana Diana , Aksoy Naciye , Sugiyo Sugiyo , Nafisah Aisyah Durrotun , Rumpoko Anisa Utamiyanti Tri
Published: March 2024

The involvement of children’s aspirations is an essential part of educational research that encourages effective learning and well-being among children. Thus, this study aims to promote children’s aspirations of starting schools during the post-pandemic situation. It implemented a face-to-face and online interview involving 63 first graders of primary school level aged seven years, consisting of 24 male and 39 female, by adhering to the prevailing health protocols. The thematic analysis generated two significant findings, including children’s perspectives and their preferences for either face-to-face learning or online learning. With regards to children’s perspectives, this research suggests that children prefer to learn with their teachers and friends at school. Based on the findings, further research is required to explore the responses of children, parents, and teachers to obtain comprehensive data
Student-centered learning in the digital age: in-class adaptive instruction and best practices
Authors: Ginting Daniel , Sabudu Delli , Barella Yusawinur , Madkur Ahmad , Woods Ross , Sari Mezia Kemala
Published: March 2024

Adaptive instruction is a promising solution to the limitations of traditional classroom instruction, which assumes that all students learn in the same way and at the same pace. Adaptive instruction tailors the learning experience to each student’s needs and abilities. Several adaptive instruction tools and platforms exist, including intelligent tutoring systems, learning management systems, mobile apps, AI chatbots, and adaptive machine-learning programs. The Adaptive Instruction of Student Control Theoretical Framework suggests that allowing students to control their use of learning resources leads to better learning outcomes. Implementing adaptive instruction in higher education can be difficult due to faculty buy-in, technical infrastructure, and student motivation. Effective instructional design is crucial for adaptive instruction to support student control and maximize benefits. Overall, instructors must pay attention to student motivation and work to create learning environments that foster motivation, autonomy, and engagement to implement adaptive instruction successfully.
The synergy between workforce, students, and lecturers in collaborative learning
Authors: Marsofiyati Marsofiyati , Solihatin Etin , Situmorang Robinson
Published: March 2024

This research focuses on applying technology in collaborative learning, specifically through online platforms that connect students and the workforce. It is objective is to enhance synergy among the workforce, students, and educators to improve learning quality. The case study methodology follows Creswell’s qualitative approach with five key steps: planning the case study; data collection; analysis; result interpretation; and reporting. The research explores innovative online platforms to create a comprehensive and diverse learning experience. Technology enables access to materials, virtual classrooms, e-books, mobile learning, and internship programs, fostering flexible and engaging education. Collaborative learning with workforce participation enhances effectiveness and skills. Students gain work experience related to their fields through active interaction with practitioners. At the same time, educators refine teaching methods and understand workforce demands-the synergy among the workforce, students, and educators’ mutually beneficial relationships. The workforce leverages student resources for problem-solving and innovation, while students enhance their networks. Educators gain input for curriculum improvement. The research enhances education quality, prepares students for the dynamic workforce, and aligns educational programs with industry demands. It emphasizes the importance of collaborative learning, integrating online platforms to increase skill development.
Student’s creative thinking based on study level, learning style, gender, and combination of the three
Authors: Musdi Edwin , As'ari Abdur Rahman , Harisman Yulyanti , Syaputra Hamdani , Hevardani Kelly Angelly
Published: March 2024

All students from every level of education should have excellent and adequate creative thinking, but in Indonesia students’ creative thinking is still low. There are a lot of factors that affect creative thinking, such as learning styles. This study aimed to investigate the comparison of students’ creative thinking based on study level and learning styles, gender, and the combination of the three to determine which factor or type of students needs to be improved. This research uses a statistics descriptive method. The participants of this study were 38 senior high school students, 35 students of the teacher professional program (PPG), 24 undergraduate students (S1), and 12 master program students (S2). The instrument used in this study is a learning styles Learning style test to determine the student’s learning styles and creative thinking questions to classify the students. The results of this study are i) Students’ level of study does not determine their creativity level; ii) Based on gender, female is more creative than a man; iii) Based on the learning style, visual students is the best, followed by kinesthetic and auditory in order; and iv) Merdeka curriculum of Indonesia, nowadays, is essential to make the best learning process to improve students’ creative thinking.