bluuebunny/crossref_metadata_2025 huggingface dataset:
ESTRATÉGIAS COOPERATIVAS PARA MELHORAR A COBERTURA VACINAL EM CRIANÇAS NO ESTADO DE MINAS GERAIS, BRASIL
Authors: Lachtim Sheila Aparecida Ferreira , Palhoni Amanda Rodrigues Garcia , Da Silva Thales Philipe Rodrigues , Ribeiro Elice Eliane Nobre , Souza Janaina Fonseca Almeida , Coelho Vanessa Maria Rodrigues , Soares Adriana Coelho , Matozinhos Fernanda Penido
Published: September 2023

Objetivo: relatar a experiência das oficinas de uma pesquisa-ação do tipo intervenção elaborada para aumento da cobertura vacinal de crianças em municípios do estado de Minas Gerais. Método: relato de experiência sobre a metodologia empregada nas oficinas organizadas com objetivo de aumentar a cobertura vacinal no estado de Minas Gerais, Brasil. As oficinas foram compostas em quatro etapas: momento motivacional, núcleo contextual, núcleo integrador/planejamento e núcleo integrador/resultados. Resultados: As oficinas mostraram-se potentes na sensibilização e na indução da discussão dos indicadores de cobertura vacinal, evidenciando, inconsistências entre o Sistema de Informação do Programa Nacional de Imunizações e os registros internos dos municípios. Para além dos indicadores, as oficinas, permitiram troca de experiências entre os representantes municipais, discussão de recursos financeiros, estruturação de salas de vacina, aquisição de veículos, contratação de profissionais, entre outros. Considerações Finais: As oficinas mostram-se capaz de evidenciar a realidade dos municípios, para além do reconhecimento das necessidades para melhoria dos processos de imunização, mas também no desenvolvimento de estratégias, capazes de promover aumento das coberturas vacinais.
The study on categorizing scaffolding types of AI chatbots for primary English learning-oriented assessment.
Authors:   The Korea Association Of Primary English Education, Kwon HaeKyoung , Shim KyuNam
Published: September 2023

The purpose of this study is to explore the types of scaffolding that AI chatbots can
provide through systematic feedback based on learners' individual utterances during
elementary English learning-oriented assessment. For the study, the researcher designed
an English speaking task and implemented an learning-oriented speaking assessment
using an AI chatbot for 25 learners in the 6th grade. Subsequently, individual interviews
were conducted to analyze the learners' responses to the scaffolding. By analyzing
learner responses and transcripts of conversations between learners and chatbots, the
researcher categorized the types of scaffolding that AI chatbots can provide during
the learning-oriented assessment. As a result, first, the scaffolding can be categorized
into three areas: linguistic, cognitive, and affective. Linguistically, the chatbots
provided scaffolding for conveying meaning, language forms, and pronunciation
aspects. In the cognitive aspect, the scaffolding assisted learners in their thinking
processes, while in the affective aspect, it helped regulate frustration. Second, through
scaffolding using various strategies, learners demonstrated the ability to self-correct
erroneous utterances and gradually complete sentences on their own. In addition,
cognitive scaffolding helped learners solve challenging tasks at their current cognitive
level, and affective scaffolding contributed to improving confidence in speaking
English. The study offers implications and recommendations based on the findings.
Associação entre o uso de redes sociais e sintomas de ansiedade e depressão em estudantes
Authors: Czadotz Ana Luisa Rampazzo , Souza Elaine Fernanda Dornelas de , Ruiz Gabriela Pessinini , Orbolato Leandro Marino Takazono , Contarin Nicole Galvão , Silva Suelen Umbelino da
Published: September 2023

Objetivo: Identificar a associação entre o uso de redes sociais e sintomas de ansiedade e depressão em acadêmicos de Medicina. Métodos: Estudo observacional e transversal em que participaram 181 alunos, dentre os quais 136 mulheres e 45 homens, com faixa etária entre 17 e 49 anos, do curso de Medicina, matriculados do 1º ao 7º termo no ano de 2021. Os participantes do estudo responderam a instrumentos on-line e avaliaram o uso de redes sociais, os sintomas depressivos e de ansiedade, sendo eles: Internet Addiction Test, Inventário de Beck para Depressão e Inventário de Beck para Ansiedade, respectivamente. Resultados: O percentual total de incidências para ansiedade moderada/grave foi de 43,2%, seguidos de 15,5% depressão moderada/grave, e 11,6% dependência da internet. Sob a ótica da estatística, os dados foram analisados com o auxílio do software RStudio, com nível de significância de 5%. Aliado a esse teste, adotou-se o teste do Qui-Quadrado para estabelecer a associação entre as categorias de ansiedade, depressão e dependência da internet. Conclusão: A pesquisa vigente reafirma aspectos importantes de distúrbios psicológicos, como ansiedade e depressão, que assolam acadêmicos da área da saúde, sobretudo do gênero feminino e acadêmicos de Medicina.
Right-Wing Populist Discourse in the European Parliament on Turkish Foreign Policy
Authors: Ulusoy Hasan , Güngörmez Oğuz
Published: September 2023

Right-wing populism is on the rise all over the world and has led to profound effects and changes in the international system. The European continent, which is identified with democracy and human rights, also sees its share of this trend. Today, right-wing populist parties and actors are gaining strength in many EU countries and come to the fore as a serious political focus. The European Parliament (EP), as an example of direct democracy, has become one of the most visible institutions facing this shift. In this article, the discourses of right-wing populist parliamentarians in the EP toward Türkiye are focused on through a social constructivist perspective. The 2009-2014 and 2014-2019 parliamentary periods are analyzed comparatively to present which discursive strategies MEPs used in their statements about Türkiye and what kind of Türkiye representation they constructed in the EP. The article benefits from critical discourse analysis studies and aims to contribute to the literature on the attitudes of right-wing populist groups on Türkiye.
Iran-Russia-Türkiye Triangle: A Challenge for the U.S. Position in the Middle East
Authors: Kumelska-Koniecko Magdalena , Czarkowska Ewa
Published: September 2023

The American-centric world order that was shaped after the end of the Cold War is being questioned by dynamically growing “old” and “new” centers of power, namely Russia and China. Entities united in opposition to American hegemony pursue policies that challenge not only the U.S. position but more importantly American interests. This process has been especially visible in the wake of the civil war in Syria. This article aims to analyze the U.S. Middle East strategy in the context of the ongoing redistribution of power in the region, influenced by the Iran-Russia-Türkiye triangle. It claims that Syria’s civil war stimulated the formation of this triangle and significantly influenced the further evolution of the balance of power in the region, posing both a direct challenge and an indirect threat to the American position and its interests in the Middle East. The article argues for the necessity of correcting the American Middle East strategy, as the one implemented so far opened the door to other powers to compete for influence in the Middle East.
A Founding Role in Türkiye’s Africa Policy: The Action Plan for Opening to Africa
Authors: Öztürk Mehmet , Duman Melih
Published: September 2023

In direct proportion to the development of Türkiye’s relations with Africa, the number of studies on bilateral relations is also increasing. However, the Action Plan for Opening to Africa, which was prepared in 1998, is a milestone in Türkiye’s relations with Africa and has not been examined specifically and in-depth. This study aims to examine all aspects of the Action Plan for Opening to Africa, which plays a founding role in Türkiye’s Africa policy. In this context, the focus is on the content of the plan, the internal and external developments that brought it about, and the role of foreign policymakers who put these developments through the filter of their perception. To guide the analysis of these issues focused on in the study, role theory and documentary source screening based on Ministry of Foreign Affairs sources were used to examine the Action Plan. As a result of the study, it has been observed that the systemic conditions affecting Turkish foreign policy after the Cold War and the Action Plan put forward as a visionary foreign policy step by İsmail Cem, who served as the foreign minister, especially under the conditions of coalition governments, played a founding role in Türkiye’s relations with the continent.
The Cyprus Conflict: A Case for ‘Joint Decision Trap’
Authors: Ulusoy Kıvanç , Atakara Pınar
Published: September 2023

This paper is about the current stage of the Cyprus conflict in the context of the recent developments in the Eastern Mediterranean. The energy discoveries could have been a catalyst for a solution, but the opposite occurred. The Greek Cypriot administration aimed to expand its regional ‘allies’ through maritime delimitation agreements. Meanwhile, Türkiye has continued its exploratory drilling. The trajectory that the Cyprus conflict followed after the Greek Cypriot administration’s EU membership in 2004 is a case of a ‘joint decision trap.’ The EU’s paralysis towards the conflict has pushed Türkiye, once proactive to resolve it with the expectation of becoming an EU member, to slide back to its traditional hard power strategy.
Post-Ottoman Legacy in the Middle East: A Compendium of 100 Years of Turkish Foreign Policy
Authors: Bakir Ali
Published: September 2023

The dissolution of the Ottoman Empire set the stage for Türkiye’s evolving foreign policy in the Middle East, a region deeply intertwined with its historical legacy. From the Treaty of Lausanne in 1923 to the rise of the AK Party in the early 2000s, Türkiye’s approach has been marked by pragmatism, adaptability, and a keen understanding of regional dynamics. The nation's foreign policy has oscillated between neutrality, revisionism, proactivity, reactivity, assertiveness, autonomy, and diplomacy, reflecting both its historical ties and strategic imperatives. As Türkiye continues to navigate the complexities of the Middle East, its foreign policy remains a testament to its enduring resilience and strategic acumen. By tracing its roots and evolution, the article sheds light on the myriad factors that have shaped its course, offering insights into the evolving nature of Türkiye’s multifaceted and adaptive foreign policy and role in the Middle East over the last 100 years (1923-2023).
Blunt Abdominal Trauma Severity Scoring System: Exceptional Score in Blunt Abdominal Trauma Management
Authors: Shah Jaimin D , Shah Tapan A , Modi Jatinkumar B
Published: September 2023

Objectives

The abdomen is a diagnostic black box. Physical examination of the abdomen is unreliable in making this determination, and sometimes clinical evaluation is difficult due to the influence of drugs or alcohol by patients or abdominal injuries occurring with head or spinal cord injuries. However, the presence of abdominal rigidity or hemodynamic compromise is an indication for prompt surgical exploration. For the remainder of patients, a variety of diagnostic adjuncts are used to identify abdominal injury. In this study, our aim is to find the answer of these questions, (1) What was the major indication for operation in each case? (2) Did delays in getting the patient to the operating room affect the outcome? (3) How to find morbidity and mortality in blunt abdominal injuries, at the behest of the Blunt Abdominal Trauma Severity Scoring System (BATSS).

Material and Methods

A retrospective study of 100 cases of blunt abdominal trauma was done Sheth Lallubhai Gordhandas Municipal General Hospital, Narendra Modi Medical College, Ahmedabad, for the accuracy of the BATSS score. Patients were divided into three groups according to the BATSS: (1) ≥12 score group, (2) 8–11 score group, and (3) <8 score group.

Results

Operative management was more common in the high-risk group, while the low-risk group was managed conservatively under expert guidance. The mean BATSS scores in operative and conservative management were 14.77 ± 2.91 and 5.12 ± 2.56, respectively. The BATSS score had an 87.1% Specificity, 100% Sensitivity, 94.5% Negative Predictive value (NPV), 100% Positive Predictive value (PPV) and an overall Accuracy of 96%.

Conclusion

BATSS is important for triage and is an excellent tool for recognising and picking up high-risk patients with blunt abdominal injuries.
Aplikasi Analisis Jalur Untuk Mengetahui Pengaruh Experimental Marketing, Trust, dan Customer Satisfaction terhadap Customer Loyalty
Authors: Rizqiana Zulfanita Dien
Published: September 2023

Tujuan penelitian ini untuk mengetahui pengaruh langsung dan tidak langsung pada Experimental Marketing dan Trust terhadap Customer Loyalty dengan Customer Loyalty sebagai variabel mediasinya menggunakan analisis jalur. Studi ini dilakukan dengan studi kasus Mie Gacoan di Solo Raya. Teknik sampling yang digunakan digunakan pada studi ini yaitu purposive sampling dengan jumlah sampel yaitu sebanyak 148 responden. Responden yang digunakan pada studi yaitu konsumen Mie Gacoan di Solo Raya. Variabel pada studi ini yaitu variabel bebas  adalah Experimental Marketing, Trust, Customer Satisfaction sebagai variabel mediasi dan Customer Loyalty sebagai variabel terikat Hasil analisis jalur pada studi ini yaitu variabel bebas   (Experimental Marketing) dan variabel bebas   (Trust) secara langsung berpengaruh signifikan  terhadap variabel mediasi   (Customer Satisfaction) dan variabel terikat  (Customer Loyalty). Pengaruh tidak lansgung variabel mediasi  (Customer Satisfaction) berpengaruh tidak signifikan pada hubungan antara variabel bebas   (Experimental Marketing) dengan variabel terikat  (Customer Loyalty) dan hubungan variabel bebas   (Trust) dengan variabel terikat  (Customer Loyalty).
ANALISIS SISTEM ANTRIAN PADA LOKET PENDAFTARAN BPJS RUMAH SAKIT PARU Dr. H. A. ROTINSULU BANDUNG
Authors: Santi Santi , Marwati Rini , Puspita Entit
Published: September 2023

Sistem antrian Markovian merupakan sistem antrian dengan rata-rata kedatangan mengikuti distribusi Poisson dan rata-rata pelayanan mengikuti distribusi Eksponensial yang dinotasikan dengan M/M/c. Sedangkan apabila rata-rata pelayanan tidak mengikuti distribusi Eksponensial, maka diasumsikan mengikuti distribusi general yang dinotasikan dengan M/G/c. Ketika proses pelayanan sedang berlangsung, beberapa server sering kali melakukan penundaan pelayanan. Penundaan tersebut terjadi karena beberapa faktor, seperti terdapat gangguan teknis pada saat proses pelayanan, server yang harus melakukan tugas sekunder, server yang harus memeriksa kembali data yang diperoleh atau server yang membutuhkan waktu untuk beristirahat sejenak. Kejadian ketika server tidak dapat melayani antrian pada saat proses pelayanan sedang berlangsung dianggap sebagai vacation. Sistem antrian M/M/c dengan vacation yang dilakukan oleh server secara tidak bersamaan dan lebih dari satu kali disebu Asynchronous Multiple Vacations Model dengan notasi M/M/c (AS,MV). Penelitian pada kasus antrian yang terjadi di loket pendaftaran BPJS Rumah Sakit Paru Dr. H. A. Rotinsulu Bandung menunjukan bahwa antrian pada hari Senin, Selasa, Rabu dan Kamis mengikuti model antrian M/M/2 (AS,MV), sedangkan pada hari Jumat mengikuti model antrian M/G/2 (AS,MV).
NORMA PADA RUANG BERNORMA-n BERDIMENSI TERTENTU
Authors: Batkunde Harmanus , Rumlawang Francis Yunito
Published: September 2023

Penelitian ini bertujuan untuk meninjau norma di ruang bernorma-. Lebih tepatnya norma yang diturunkan dari norma- yang didefinisikan pada ruang tersebut. Lebih lanjut bentuk norma ini merupakan bentuk norma yg sederhana, dilihat dari pendefinisiannya, secara khusus untuk banyaknya suku penjumlahan yang ada. Kami memberikan syarat bagi ruang bernorma- sehingga norma ini dapat didefinisikan. Syarat yang dimaksud berkaitan dengan dimensi ruang tersebut.
ANALISIS DANA TABARRU’ PRODUK ASURANSI JIWA TRADISIONAL SYARIAH
Authors: Andirasdini Indah Gumala , Nurtandhee Mutiara
Published: September 2023

Dana tabarru’ sangat penting dalam setiap produk asuransi syariah karena merupakan dana yang digunakan untuk membayar klaim dari peserta.Melalui dana tabarru’ produk asuransi syariah mengajarkan nilai-nilai sosial dan kemanusiaan yang terkandung dalam prinsip keuangan Islam.Penelitian ini bertujuan untuk menghitung dan menganalisis perhitungan iuran dan dana tabarru’ produk asuransi jiwa tradisional syariah perusahaan PT Asuransi Allianz Life.  Produk ini memberikan manfaat perlindungan jiwa dan penyakit kritis serta adanya dana tabungan.  Hasil perhitungan tabarru dan sisa dana tabarru’ menggunakan data sampel yang terdiri atas 1000 peserta asuransi dari tahun 2009-2015. Asumsi perhitungan yang digunakan adalah tidak ada penambahan peserta dalam kurun waktu tersebut..  Produk penelitian ini memberikan analisa bahwa dana tabarru yang terkumpul habis di tahun ketiga asuransi. Semakin banyak peserta yang mengajukan klaim/ meninggal dunia pada kurun waktu tersebut maka semakin besar klaim yang harus dibayarkan oleh perusahaan. Hal ini berhubungan dengan produk asuransi yang digunakan, manfaat yang akan diperoleh, usia dan masa polis peserta.
Effects of Surface Chemistry on the Mechanochemical Decomposition of Lubricant Additives
Authors: Ogbomo Egheosa , Bhuiyan Fakhrul H. , Latorre Carlos Ayestaran , Martini Ashlie , Ewen James
Published: September 2023

The growth of protective tribofilms from lubricant antiwear additives on rubbing surfaces is initiated by mechanochemical decomposition reactions. These processes are not well understood at the molecular scale for many important additives, such as tricresyl phosphate (TCP). One aspect that needs further clarification is the extent to which the surface properties affect the mechanochemical decomposition rate. In this study, we use nonequilibrium molecular dynamics (NEMD) simulations with a reactive force field (ReaxFF) to study the decomposition of TCP molecules confined and pressurised between sliding ferrous surfaces at a range of temperatures. We compare the decomposition of TCP on native iron, iron carbide, and iron oxide surfaces. We show that the decomposition rate of TCP molecules increases exponentially with temperature and shear stress, implying that this is a stress-augmented thermally activated process. The rates and products of decomposition depend on the properties of the confining surfaces. The activation energy, activation volume, and pre-exponential factor are similar for TCP decomposition between iron and iron carbide surfaces, but significantly different for iron oxide surfaces. These findings provide new insights into the mechanochemical decomposition of TCP and have important implications for the design of novel lubricant additives for use in high-temperature and high-pressure environments'
Unraveling Luminescence Quenching Mechanism in Strong and Weak Quantum-Confined CsPbBr3 Triggered by Triarylamine-Based Hole Transport Layers
Authors: Kshirsagar Anuraj S , Koch Katherine A , Kandada Ajay Ram Srimath , Gangishetty Mahesh K
Published: September 2023

Luminescence quenching by hole transport layers (HTLs) is one of the major issues in developing efficient perovskite light-emitting diodes (PeLEDs); particularly, it is more prominent in blue LEDs. Often, various interfacial layers are used to overcome this issue. However, the origin of such quenching and the type of interactions between perovskites and HTLs are still ambiguous. Here, we present a systematic investigation of the luminescence quenching of CsPbBr3 by a commonly employed hole transport polymer, Poly(9,9-dioctylfluorene-alt-N-(4-sec-butylphenyl)-diphenylamine) (TFB) in LEDs. Strong and weak quantum-confined CsPbBr3 (nanoplatelets (NPLs)/nanocrystals (NCs)) are rationally selected to study the quenching mechanism by considering the differences in their morphology, energy level alignments, and quantum confinement. The steady-state and time-resolved Stern-Volmer plots unravel the dominance of dynamic and static quenching at lower and higher concentrations of TFB, respectively, with maximum quenching efficiency of 98 %. The quenching rate in NCs is faster than in NPLs owing to their longer PL lifetimes and weak quantum confinement. The ultrafast transient absorption results support these dynamics and rule out the involvement of Forster or Dexter energy transfer. Finally, the 1D 1H and 2D NOESY NMR study confirms the exchange of native ligands at the NCs surface with TFB, leading to dark CsPbBr3-TFB ensemble formation accountable for luminescence quenching. This highlights the critical role of the triarylamine functional group on TFB (which is also the backbone of many HTLs) in the quenching process. These results shed light on the underlying reasons for the luminescence quenching in PeLEDs and will help to choose the interfacial layers rationally for developing efficient LEDs.
Tuning Potential Functions to Host–Guest Binding Data
Authors: Setiadi Jeffry , Boothroyd Simon , Slochower David , Dotson David , Thompson Matthew , Wagner Jeffrey , Wang Lee-Ping , Gilson Michael K.
Published: September 2023

Software to more rapidly and accurately predict protein--ligand binding affinities is of high interest for early-stage drug discovery, and physics-based methods are among the most widely used technologies for this purpose. The accuracy of these methods depends critically on the accuracy of the potential functions they use. Potential functions are typically trained against a combination of quantum chemical and experimental data. However, although binding affinities are among the most important quantities to predict, experimental binding affinities have not to date been integrated into the experimental dataset used to train potential functions. In recent years, the use of host--guest complexes as simple and tractable models of binding thermodynamics has gained popularity due to their small size and simplicity, relative to protein--ligand systems. Host--guest complexes can also avoid ambiguities that arise in protein--ligand systems, such as uncertain protonation states. Thus, experimental host--guest binding data are an appealing additional data type to integrate into the experimental dataset used to optimize potential functions. Here, we report the extension of the Open Force Field Evaluator framework to enable the systematic calculation of host--guest binding free energies and their gradients with respect to force field parameters, coupled with the curation of 126 host--guest complexes with available experimental binding free energies. As an initial application of this novel infrastructure, we optimized generalized Born (GB) cavity radii for the OBC2 GB implicit solvent model against experimental data for 36 host--guest systems. This refitting led to a dramatic improvement in accuracy for both the training set and a separate test set with 90 additional host--guest systems. The optimized radii also showed encouraging transferability from host--guest systems to 59 protein-ligand systems. However, the new radii are significantly smaller than the baseline radii and lead to excessively favorable hydration free energies (HFE). Thus, users of the OBC2 GB model currently may choose between GB cavity radii that yield more accurate binding affinities or GB cavity radii that yield more accurate HFEs. We suspect that achieving good accuracy on both will require more far-reaching adjustments to the GB model. We note that binding free energy calculations using the OBC2 model in OpenMM gain about a 10x speedup relative to corresponding explicit solvent calculations, suggesting a future role for implicit solvent absolute binding free energy (ABFE) calculations in virtual compound screening. This study proves the principle of using host--guest systems to train potential functions that are transferrable to protein--ligand systems, and provides an infrastructure that enables a range of applications.
Insights into Molten Salts Induced Structural Defects in Graphitic Carbon Nitrides for Piezo-Photocatalysis with Multiple H2O2 Production Channels
Authors: Phuong Ly Pho , Nguyen Duc-Viet , Tuyen Luu Anh , Hung Nguyen Quang , Hue Pham Thi , Hue Nguyen Thi Ngoc , Pham Minh-Thuan , Ung Thuy Thi Dieu , Bich Do Danh , Minh Phan Pham Duc , Anh Nguyen Hoai , Toan Huynh Phuoc , Bui Dai-Phat , Hur Seung Hyun , Vuong Hoai-Thanh
Published: September 2023

Recently, the production of hydrogen peroxide (H2O2) from water (H2O) and oxygen (O2) in the presence of graphitic carbon nitrides (g-C3N4) via a piezo-photocatalytic process has considerably ignited global interest in achieving sustainability. To fabricate porous g-C3N4, soft templates are frequently employed, leading to structural modifications originating from heteroatoms. However, many recent reports have ignored the roles of trace quantity of heteroatoms. Hence, to understand the impacts of the mentioned factors, we fabricated g-C3N4 containing oxygen and halogen atoms in the structures for piezo-photosynthesis of H2O2. Based on our analyzed results, oxygen atoms might be inserted into g-C3N4 in-plane structures, while halogen atoms tend to become intercalated between g-C3N4 layers. Furthermore, the presence of ammonium molten salts during the synthesis alters the concentration of mono and cluster vacancies of carbon and nitrogen in the materials. These defective contributions would meaningfully accelerate catalytic performance by providing trapping states. From the mechanistic view, different reduction and oxidation channels would play a pivotal role in generating H2O2. Thus, this study highlights the importance of modulating in-plane and out-of-plane structures of g-C3N4, benefiting catalytic properties under simultaneous irradiation.
Catalyst Engineering for the Selective Reduction of CO2 to CH4; A First-Principles Study on X-MOF-74 (X = Mg, Mn, Fe, Co, Ni, Cu, Zn)
Authors: McCarver Gavin , Yildirim Taner , Zhou Wei
Published: September 2023

The conversion of carbon dioxide (CO2) into more valuable chemical compounds represents a critical objective for addressing environmental challenges and advancing sustainable energy sources. The CO2 reduction reaction (CO2RR) holds promise for transforming CO2 into versatile feedstock materials and fuels. Leveraging first-principles methodologies provides a robust approach to evaluate catalysts and steer experimental efforts. In this study, we examine the CO2RR process using a diverse array of representative cluster models derived from X-MOF-74 (where X encompasses Mg, Mn, Fe, Co, Ni, Cu, or Zn) through first-principles methods. Notably, our investigation highlights the Fe-MOF-74 cluster's unique attributes, including favorable CO2 binding and the lowest limiting potential of the studied clusters for converting CO2 to methane (CH4) at 0.32 eV. Our analysis identified critical factors driving the selective CO2RR pathway, enabling the formation CH4 on the Fe-MOF-74 cluster. These factors involve less favorable reduction of hydrogen to H2 and strong binding affinities between the Fe open-metal site and reduction intermediates, effectively curtailing desorption processes of closed-shell intermediates such as formic acid (HCOOH), formaldehyde (CH2O), and methanol (CH3OH), to lead to selective CH4 formation.
Biodegradability of Carbon Nano-Onions by Human Myeloperoxidase and the Photo-Fenton Reaction
Authors: K Swetha , Camisasca Adalberto , Bartkowski Michał , Garhwal Akash , K Prathiksha , Aravind Ananya , Giordani Silvia , Kurapati Dr. Rajendra
Published: September 2023

The biodegradability of graphene family materials (GFMs) in the environment and organisms is little understood to estimate their fate and possible byproducts. Herein, for the first time, we explored the biodegradability of multilayer fullerenes or carbon nano-onions (CNOs) by treating with human myeloperoxidase (hMPO) isolated from the neutrophils and plant enzyme horseradish peroxidase (HRP) and photo-Fenton (PF) reaction under UV-light irradiation. High-resolution electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and Mass spectrometry results confirmed that CNOs are not biopersistent. These results will be useful in understanding the fate of CNOs and designing their biomedical applications.
Long Live(d) CsPbBr3 Superlattices: Colloidal Atomic Layer Deposition for Structural Stability
Authors: Lapointe Victoria , Green Philippe , Chen Alexander , Buonsanti Raffaella , Majewski Marek
Published: September 2023

Metal halide perovskite nanocrystals self-assemble under slow solvent evaporation leading to formation of superlattices that are interesting because of their collective photophysical properties, such as superfluorescence. These collective properties are, ostensibly, directly influenced by the stability of the perovskite nanocrystals and their dynamic surface chemistry, both factors that dictate the stability of the superlattice. In this work, we report on the formation of superlattices from aluminum oxide shelled CsPbBr3 perovskite nanocrystals where the oxide shell is grown by colloidal atomic layer deposition. We demonstrate that the structural stability of these superlattices is preserved over 25 days and that colloidal atomic layer deposition yields structural protection and an enhancement in photoluminescence quantum yields and radiative lifetimes as opposed to gas phase atomic layer deposition or excess capping group addition. Structural analyses found that shelling resulted in smaller nanocrystals that pack more tightly within the superlattice forming uniform supercrystals due to the aluminum oxide layers that cause increasingly hard cube behavior leading to a higher packing density than superlattices assembled from softer cubes without aluminum oxide. These effects are in addition to the increasingly static capping group chemistry initiated when oleic acid is used to terminate atomic layer deposition and is subsequently installed as a capping ligand directly on aluminum oxide. Together, these factors lead to fundamental observations that may influence future superlattice assembly design.
Total Synthesis of Dynobactin A
Authors: Schneider Fabian , Guo Yinliang , Lin You-Chen , Eberle Kelly , Chiodi Debora , Greene Jonathan , Lu Chenxin , baran phil
Published: September 2023

The first total synthesis of the potent antimicrobial agent dynobactin A is disclosed. This synthesis capitalizes on the hidden symmetry present in this complex decapeptide by enlisting an aziridine ring opening strategy to access b-branched amino acids. Featuring a number of unique maneuvers to navigate inherently sensitive and epimerizable functional groups, this convergent approach proceeds in only 14 steps (LLS) from commercial materials and should facilitate the synthesis of numerous analogs for medicinal chemistry studies.
Modelling Stock Market Volatility During the COVID-19 Pandemic: Evidence from BRICS Countries
Authors: Banumathy Karunanithy
Published: September 2023

The objective of the research paper is to identify the stock market volatility pattern of BRICS countries during the outbreak of the COVID-19 pandemic. The study is based on the time series data, which consists of the daily closing price of the BRICS countries' index for a two-year (pandemic) period from 1st January 2020 to 31st December 2021. Both the symmetric and asymmetric models of Generalized Autoregressive Conditional Heteroscedasticity (GARCH) have been employed in the study to investigate whether volatility changes over the pandemic period. The result of the GARCH-M (1,1) model evidenced the presence of a positive and insignificant risk premium. Based on the empirical work carried out using the market index of BRICS countries, it was found from EGARCH (1,1), and TGARCH (1,1) models that there exists a leverage effect in the countries, viz. Brazil, Russia, India, China and South Africa. Since the stock price during the pandemic period triggered the entire financial market, the investors, fund managers and portfolio managers should be more aware of the uncertainty and need to adjust their investments accordingly.
Estrategia de gamificación para la formación de estudiantes de ingeniería: caso de estudio con Lean Manufacturing
Authors: Gasca Hurtado Gloria Piedad , Restrepo Tamayo Luz Marcela , Gómez Álvarez María Clara , Morillo Puente Solbey , Hernández Leal Emilcy Juliana
Published: September 2023

Las metodologías de mejoramiento continuo permean los procesos de los diferentes sectores económicos. Una de las metodologías más relevantes es Lean Manufacturing que se aborda tanto en Ingeniería de Sistemas como en Ingeniería Industrial. Una dificultad de la enseñanza del mejoramiento continuo está asociada con su alto componente teórico y el nivel de abstracción requerido. Pero dado que la gamificación promueve la motivación y el compromiso al incluir elementos de juego en el contexto educativo, se ha identificado que es posible enseñar los principios de Lean Manufacturing a partir de una actividad gamificada. Lean Poker Card es una actividad que se desarrolla durante seis iteraciones en equipos de cuatro integrantes. El objetivo de este trabajo es caracterizar esta actividad identificando los principios de gamificación incorporados en las iteraciones que se llevan a cabo. Como parte de este trabajo se reportan los resultados de aplicar esta actividad en grupos de estudiantes de Ingeniería de Sistemas e Ingeniería Industrial. Se evidencia una disminución en el tiempo de ejecución de cada iteración, determinado a partir de una gráfica de consolidación de tiempos y la buena percepción tanto de los estudiantes como de los profesores frente a la inclusión de este tipo de actividad en el aula de clase. El trabajo futuro está relacionado con la medición de factores como la motivación, la comunicación o el trabajo en equipo utilizando estudios empíricos de investigación.
Una experiencia sobre el proceso de medición del SO7
Authors: Ortega Homero , Quiroga Quiroga Óscar , Martínez Carlos Mario
Published: September 2023

En el modelo de acreditación ABET, la formación en un programa de ingeniería gira en torno a siete (7) Student Outcomes (SOs) que abarcan las capacidades básicas que debe desarrollar el estudiante antes de enfrentarse al ejercicio profesional. En ese modelo, el SO7 trata de la capacidad de adquirir y aplicar nuevos conocimientos según sea necesario, utilizando estrategias de aprendizaje apropiadas. No obstante, valorar el nivel de desempeño que logran los estudiantes en este SO7 resulta un desafío, por lo cual en los programas de Ingeniería Eléctrica e Ingeniería Electrónica de la Universidad Industrial de Santander, se ha desarrollado una metodología sencilla para hacer esa evaluación y detectar oportunidades de mejora para los programas. En este trabajo, se explica el proceso de diseño del instrumento, la forma en que se aplica a lo largo de un curso y cómo se preparan los estudiantes para aumentar la sensibilidad de las mediciones. Todo comienza con el diseño de la herramienta de evaluación, su lanzamiento en forma de desafío de investigación para los estudiantes durante una clase práctica. A lo largo del semestre, los estudiantes siguen varias fases para adquirir y aplicar nuevos conocimientos, pero también se implementan algunas estrategias pedagógicas para permitir que los estudiantes se empoderen y demuestren sus habilidades para adquirir nuevos conocimientos. Finalmente se muestran algunos resultados que se obtuvieron para el SO7 en los dos programas mencionados y se resalta la importancia de este SO para el desarrollo profesional de un ingeniero.
Logro ágil de resultados de aprendizaje en ingeniería desde la obra de El Principito
Authors: Peláez Valencia Luis , Osorio Patiño Beatriz , Delgado González Iván Andrés
Published: September 2023

A menudo resulta necesario encontrar estrategias que permitan mejorar notable y significativamente el aprendizaje en los programas de formación en ingeniería. El área de proyectos es un área transversal en todas las ingenierías y esto la convierte en un dispositivo adecuado para apropiar nuevas estrategias de enseñanza de tal forma que se pueda experimentar con aprendizajes significativos, situados en el contexto de la ingeniería, pero sujetos a innovaciones desde estrategias que no son propias de la ingeniería, como en este caso que nos ocupa, desde la literatura universal. El Principito de Antoine de Saint-Exupéry es una obra de literatura importante para la humanidad; un conjunto de narrativas que permiten metáforas en forma de preguntas y cuestionamientos de un muchachito encantador del que se tiene evidencia de su existencia, precisamente porque era encantador y porque quería un cordero; querer un cordero es prueba suficiente de que se existe. Esos viajes en forma de narrativa, de analogía, de metáfora de situaciones circunstanciales con personas, animales y objetos han sido analizados en el contexto de la ingeniería durante los últimos diez años y se han podido implementar en procesos de enseñanza arrojando resultados impresionantes, significativos, tal vez en correspondencia, pero guardando las proporciones, con el impacto dejado por la misma obra. Este trabajo da cuenta de un estudio de caso formulado, ejecutado y evaluado en un programa de ingeniería mediante el cual se descubren aspectos significativos de aprendizaje a partir de la implementación de los pasajes de la obra y su estrecha relación con el aprendizaje de formulación y evaluación de proyectos de ingeniería. Se elabora un análisis comparativo en forma de pretest y postest, resultados e impacto en el logro ágil de los resultados de aprendizaje propuestos mediante dos escenarios de formación diferentes: uno de la forma tradicional y otro con la incorporación de las estrategias propias de lo extraído de la obra de Antoine de Saint-Exupéry.
Análisis de contexto para el programa Ingeniería de sistemas e informática de la Universidad Nacional de Colombia
Authors: Moreno Julián
Published: September 2023

Con el objetivo de continuar fortaleciendo los procesos de aseguramiento de la calidad de la educación superior, el gobierno nacional expidió el Decreto 1330 de 25 de 2019 relacionado con el Registro Calificado de las Instituciones de Educación Superior, para el ámbito local, regional y nacional. Parte de este marco normativo se refiere a la integración de resultados de aprendizaje como un factor a tener en cuenta dentro de la cultura de autoevaluación, entendiéndolos como las declaraciones expresas de lo que se espera que un estudiante conozca y demuestre en el momento de completar su programa académico. Y para la definición de dichos resultados, en la Facultad de Minas de la Universidad Nacional de Colombia se ha optado por partir de un análisis de contexto de los programas, el cual corresponde a la evaluación detallada del entorno y las circunstancias en las que se desarrollan esos programas. En este artículo se presenta este análisis de contexto en detalle para el caso del programa de Ingeniería de Sistemas e Informática, buscando con ello la actualización del mismo, no solo en términos de la definición de los resultados de aprendizaje a los que hace referencia el decreto, sino también buscando que el programa sea relevante, efectivo y actualizado.
Resilience and Recovery: Insights from the July 2022 Eastern Kentucky Flood
Authors: Klesta Matthew
Published: September 2023

Because of its topography, location, and coal mining legacy, eastern Kentucky has a long history of flooding. This report focuses on housing in the 13 counties declared federal disaster areas after the July 2022 flood.
Physical Activities of Working Communities During the COVID-19 Pandemic With Hypertension Incidence in Indralaya District
Authors: Pratama Solin , Yeni Yeni
Published: September 2023

According to WHO, one in three people in the world suffers from hypertension. Riskesdas results showed that the prevalence of hypertension in Indonesia has increased to 34.1% in 2018. In Ogan Ilir Regency, there had been an increase in cases of hypertension during the Covid-19 pandemic. One important factor was physical activity. The purpose of this study aimed to determine the relationship between physical activity and the incidence of hypertension in workers. The design of this research was a quantitative study with a cross-sectional study design. The population was all workers aged over 25 years in Ogan Ilir district. The sample in this study were workers aged 25 years and lived in Indralaya, namely 100 respondents. The sampling technique was purposive sampling. Data analysis used the chi square test and multiple logistic regression risk factor models. The results of the bivariate analysis showed a relationship between physical activity variables, age, consumption of salty foods, consumption of fatty foods, central obesity, sleep quality, and stress variable with hypertension (p-value <0.05). The results of the multivariate analysis showed a significant relationship between physical activity and hypertension after controlling for the consumption of fatty foods, central obesity and sleep quality (PR 2 4.29; 95% CI: 4.68 – 125.98). Lack of physical activity was a risk factor for hypertension in workers. It was important to prevent hypertension by getting used to moderate-intensity physical activity for at least 30 minutes a day such as cleaning the house, walking, and exercising.
Modern views on the correction of violations of the vaginal biotope in perimenopause
Authors: Kravchenko Elena
Published: September 2023

ABSTRACT. Ensuring the quality of life of women in the climacteric period remains today the most urgent problem of modern medicine. The goal is to evaluate the effectiveness of the antiseptic Ginodec in the treatment of mixed vulvovaginal infection in perimenopausal women. Materials and methods. We monitored 52 patients with mixed bacterial and candidal infection aged 44 to 52 years. The diagnosis of non-specific bacterial and candidal infection was verified according to the data of clinical and laboratory research methods. The criteria for the effectiveness of the treatment were complete clinical and bacterial sanitation. Patients with bacterial candidal infection received 5 ml of Ginodek vaginal gel once a night for 7 days. The results. Analysis of clinical effectiveness after treatment showed that in perimenopausal women, complaints of vaginal discomfort and vaginal discharge decreased by 4 times, dyspareunia was noted by only 5.8 % of patients compared to 69.2 % before treatment. Regenerative efficiency of vaginal epithelial cells in patients also improved, their maturity index increased to 75-80. Bacteriological examination carried out 2 weeks after the end of the course of treatment confirmed the effectiveness of the Ginodek drug against bacterial infection in 92.3 % of cases, candidal - in 86.5 %. Conclusions. Bacterial-fungal associations of microorganisms in the vaginal biotope in women in the perimenopausal period lead to the formation of a complex complex of unclear clinical symptoms, which makes it difficult to make a timely diagnosis. The drug Ginodek demonstrates high microbiological effectiveness in mixed bacterial-candidal infection in patients in perimenopause, and also increases the functional activity of the epithelium of the mucous membrane of the vagina, which is especially important in this period of a woman's life.
The corrective effect of Au/Ag/Fe nanoparticles on oxidative stress in terms induced colon adenocarcinoma
Authors: Andriychuk Iryna , Grytsyshyn Liliia , Ivanchuk Iryna , Soroka Yurii , Lisnychuk Natalia
Published: September 2023

ABSTRACT. Studying biological markers of oxidative stress is crucial and relevant, as this process can trigger the transition from an organ's "normal state" to a "malignant lesion". The use of metal nanoparticles to correct oxidative stress manifestations in oncology is one of the most popular subjects of modern science and is actively being introduced into modern medicine. Practically all possible types of nanoparticles have found their use in solving different problems in oncology. Therefore, our study aimed to investigate the possibility of Au/Ag/Fe nanoparticles use for the correction of redox balance disorders of the antioxidant system under the conditions of induced colon adenocarcinoma. Materials and methods. The study was performed on 150 white male rats. Animals were kept in standard vivarium conditions. Division of experimental rats into groups: I - control intact group (40 individuals); II - experimental group (70 individuals) with N,N-dimethylhydrazine hydrochloride administration once a week for 30 weeks; ІІІ – an experimental group (40 animals) with daily intragastric administration of Au/Ag/Fe nanoparticles. Oxidative stress was assessed in colon tissue homogenate by changes in the concentrations of 8-iso-prostaglandin F2α (8-iso-PGF2α), TBC-active products, diene and triene conjugates, Schiff bases, as well as by the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and reduced glutathione. Results. Due to this research, we established that Au/Ag/Fe nanoparticles use leads to a decrease in the concentration of 8-iso-prostaglandin F2α (8-iso-PGF2α), TBC-active substances, diene, triene conjugates, Schiff bases. As a result of the above, we observed a reduction of manifestations of oxidative stress and restoration of enzymes of the antioxidant system and its biological mediators of a non-enzymatic nature. The activity of catalase, superoxide dismutase, glutathione peroxidase, and the concentration of reduced glutathione was restored to control indicators. Conclusions. Therefore, the use of Au/Ag/Fe nanoparticles leads to the restoration of the balance of redox equilibrium, improving the antioxidant system with induced adenocarcinoma of the large intestine.