bluuebunny/crossref_metadata_2025 huggingface dataset:
Promotion of catalytic ozonation of aniline with Mn-Ce-Ox/γ-Al2O3
Authors: Xu Xuelu , Zhao Jiao , Jiang Yunfei , Tang Xiaojia , Zhou Zihao , Zhu Yimin
Published: July 2018

In this study, Mn-Ce-Ox/γ-Al2O3 supported catalysts were adopted to promote the removal efficiency of aniline in simulated wastewater with ozone. Mn-Ce-Ox/γ-Al2O3 catalysts were prepared by the impregnation-calcination method. Its phase structure, specific surface area, loading amount and distribution of active units were analyzed by XRD, BET, ICP-AES and TEM/SEM respectively. The characterization results demonstrated that the catalysts had a good dispersion of Mn-Ce-Ox active sites and an abundant porous structure from the γ-Al2O3 support. The catalytic ozonation results showed that with Mn3-Ce1-Ox/γ-Al2O3(1.0), the aniline removal efficiency was highly improved, 15.0% higher than that of ozonation without a catalyst. Furthermore, from the variation in loading amounts of Mn and Ce, it can be seen that the molar ratio of Mn and Ce within the Mn-Ce-Ox plays a key role in accelerating the ozonation of aniline in simulated wastewater with ozone, while Mn:Ce = 1.9:1 showed the best performance. More importantly, the catalysts showed high recycling performance and could be reused at least 12 times without obvious loss of activity.
Zero-valent iron nanoparticles for methylene blue removal from aqueous solutions and textile wastewater treatment, with cost estimation
Authors: Hamdy Ahmed , Mostafa Mohamed K. , Nasr Mahmoud
Published: July 2018

Nanoscale zero-valent iron (nZVI) particles were investigated for the removal of methylene blue (MB) from aqueous solutions and the treatment of textile industry effluents. The nZVI material was characterized by XRD, TEM, EDS, FTIR, and SEM. It was demonstrated that several functional groups such as C–H, C = C, C–C, and C–O contributed to MB reduction. At initial MB concentration of 70 mg/L, the optimum pH was 6, achieving a removal efficiency of 72.1% using an nZVI dosage of 10 g/L, stirring rate of 150 rpm, and temperature of 30 °C within 30 min. The adsorption isotherm was described by the Langmuir model with monolayer coverage of 5.53 mg/g, and the Freundlich equation with multilayer adsorption capacity of 1.59 (mg/g)·(L/mg)1/n. The removal mechanisms of MB included reduction into colorless leuco-MB, precipitation as Fe(II)-MB, adsorption as ZVI-MB or FeOOH-MB, and/or degradation using •OH radicals. The synthesized nZVI particles were applied to reduce various organic and inorganic compounds, as well as heavy metal ions from real textile wastewater samples. The removal efficiencies of COD, BOD, TN, TP, Cu2+, Zn2+, and Pb2+ reached up to 91.9%, 87.5%, 65.2%, 78.1%, 100.0%, 29.6%, and 99.0%, respectively. The treatment cost of 1 m3 of textile wastewater was estimated as 1.66 $USD.
Process Optimization for the Synthesis of Silver (AgNPs), Iron Oxide (α-Fe2O3NPs) and Core-Shell (Ag-Fe2O3CNPs) Nanoparticles Using the Aqueous Extract of Alstonia Scholaris: A Greener Approach
Authors: Shimpi Navinchandra G. , Khan Mujahid , Shirole Sharda , Sonawane Shriram
Published: July 2018

Objective:

The present study is deals with the green synthesis of silver (AgNPs), iron oxide (α-Fe2O3NPs) and core-shell (Ag-α-Fe2O3CNPs) nanoparticles using the aqueous extract ofAlstonia scholariswithout any catalyst, template or surfactant or any intermediate under ultrasound cavitation technique. The purpose was to facilitate the high level of dispersion with increase in rate of reaction. Further AgNPs and α-Fe2O3NPs were used to synthesis Ag-Fe2O3CNPs in aqueous extract ofAlstonia scholarisunder controlled ultrasound cavitation technique.

Methods:

The size of AgNPs and Ag-Fe2O3CNPs can be tuned by optimizing various reaction parameters. UV-visible, X-ray diffraction spectroscopy (XRD), Transmission electron microscopy (TEM), Field emission scanning electron microscope (FE-SEM) and Fourier transform infra-red spectroscopy has been used for the characterization of silver and core shell Ag@Fe2O3nanoparticles. TEM images clearly show the formation of core shell nanoparticles with spherical morphology.

Result:

Fourier transform infra-red spectroscopy analysis revealed that carbohydrate, polyphenols, and protein molecules were involved in the synthesis and capping of silver, iron oxide and Ag@Fe2O3CNPs.
TREATMENT OPTIONS FOR NEGLECTED ACHILLES TENDON RUPTURED: WETHER SPONTANEOUS HEALING IS POSSIBLE?
Authors: Sereda A. P.
Published: July 2018

The paper considers cases of spontaneous healing of achilles tendon with elongation. In such condition the tendon defect is not palpable, active plantar flexion is preserved and patients are complaining for strength diminution. Purpose — to study features of spontaneous achilles tendon healing with elongation and to analyze the shortening tenoplasty option as a procedure primarily aimed at restoration of strength for gastrocnemius-soleus complex.Material and Methods. The paper presents features and outcomes of surgical treatment of 25 patients who underwent a shortening tenoplasty of various types: crimping (3 patients), Z-type (2 patients), oblique (1 patient) and transverse (19 patients).Results. No re-ruptures or other serious complications were observed in the patients of the present study. Treatment outcomes were evaluated by j. leppilahti scale in 304,7±8,9 days after the procedure. postoperative leppilahti scores were statistically significantly better than prior to surgery — 82,4±5,6 and 62,2±7,7, respectively, (p0,0001). Conclusion. Shortening tenoplasty can be indicated in cases of spontaneous achilles tendon healing with elongation. at relatively early stages of the injury with rather elastic scars the crimping tenoplasty can be applied.  At later stages a resection shortening tenoplasty is recommended through a minimal incision with transverse resection of tendon and removal of scar block.
Pregnant Users’ Perceptions of the Birth Plan Interface in the “My Prenatal Care” App: Observational Validation Study (Preprint)
Authors: Moraes Carrilho Juliana , Oliveira Isaias José Ramos , Santos Dimitri , Osanan Gabriel Costa , Cruz-Correia Ricardo João , Reis Zilma Silveira Nogueira
Published: July 2018

BACKGROUND

Birth plans are meant to be a declaration of the expectations and preferences of pregnant woman regarding childbirth. The My Prenatal Care app engages pregnant women in an educational intervention for a healthy pregnancy. We hypothesized that users’ positive perception of an in-app birth plan is a relevant step for establishing direct communication between pregnant women and the health care team, based on an online report available on the app.

OBJECTIVE

This study aimed to evaluate pregnant women’s perception about the communicability of birth-plan preparation using a mobile app.

METHODS

This was an observational, exploratory, descriptive study. The methodology was user centered, and both qualitative and quantitative approaches were employed. The tools of the communicability evaluation method were applied. Overall, 11 pregnant women evaluated their experience of using a birth-plan prototype interface. The evaluation was performed in a controlled environment, with authorized video recording. There were 8 task-oriented interactions proposed to evaluate interface communicability with users when using the Birth Plan menu. For evaluating perceptions and experiences, a survey with structured and open-ended questions in addition to the free expression of participants was conducted. The primary outcomes assessed were interface communicability and user’s perception of the Birth Plan prototype interface in the My Prenatal Care mobile app. Secondarily, we involved users in the prototyping phase of the interface to identify bottlenecks for making improvements in the app.

RESULTS

Regarding users’ performance in accomplishing previously prepared tasks, we found that 10 of 11 (91%) women were capable of completing at least 6 of 8 (75%) tasks. A positive relationship was found between the number of communicability problems and the success of completing the tasks. An analysis of the records revealed three communicability breakdowns related to the data entry, save, and scrollbar functions. The participants freely expressed suggestions for improvements such as for the save function and the process of sharing the birth-plan form upon completion.

CONCLUSIONS

Users had a positive perception of the Birth Plan menu of the My Prenatal Care app. This user-centered validation enabled the identification of solutions for problems, resulting in improvements in the app.
Measuring Relevant Information in Health Social Network Conversations and Clinical Diagnosis Cases (Preprint)
Authors: Moreira Albert , Alonso-Calvo Raul , Muñoz Alberto , Crespo Jose
Published: July 2018

BACKGROUND

Internet and Social media is an enormous source of information. Health Social Networks and online collaborative environments enable users to create shared content that afterwards can be discussed. While social media discussions for health related matters constitute a potential source of knowledge, characterizing the relevance of participations from different users is a challenging task.

OBJECTIVE

The aim of this paper is to present a methodology designed for quantifying relevant information provided by different participants in clinical online discussions.

METHODS

A set of key indicators for different aspects of clinical conversations and specific clinical contributions within a discussion have been defined. These indicators make use of biomedical knowledge extraction based on standard terminologies and ontologies. These indicators allow measuring the relevance of information of each participant of the clinical conversation.

RESULTS

Proposed indicators have been applied to two discussions extracted from PatientsLikeMe, as well as to two real clinical cases from the Sanar collaborative discussion system. Results obtained from indicators in the tested cases have been compared with clinical expert opinions to check indicators validity.

CONCLUSIONS

The methodology has been successfully used for describing participant interactions in real clinical cases belonging to a collaborative clinical case discussion tool and from a conversation from a Health Social Network.
Using experiences of mobile application from the perspective of patients with diabetes mellitus: A qualitative meta-synthesis (Preprint)
Authors: Lv Xiaoyan , Cao Yingjuan , Xia Jinghua , Tan Ran , Chang Polun
Published: July 2018

BACKGROUND

Mobile application has become a new tool for management of chronic disease like diabetes mellitus (DM). Up to date, most of the studies related to mobile application focus on the effectiveness of self-management, rarely take perceptions and experiences of users into account.

OBJECTIVE

To conduct a meta- synthesis of qualitative researches which associated with mobile application using experiences among diabetic patients in order to better understand those factors which facilitate or hinder patients’ embracement, and to provide recommendations for future mobile application design and disease management strategies.

METHODS

Literatures focused on experiences and perceptions of users in diabetes application were searched in PubMed, Web of Science and Cochrane Library between inception and June 2018. The Jonna Briggs Institute (JBI) Critical Appraisal Tool for qualitative studies was utilized to evaluate the quality of the selected studies. The searching results were synthesized by employing Integrating Methods.

RESULTS

Four studies were included for analysis, 17 findings were subsequently integrated into 6 categories and finally 2 synthesized results were defined, including the use of mobile application for diabetes can improve patients’ self-management and confidence in disease control, obtain more support from health care professionals, and reduce negative emotions; Problems and negative effects in use.

CONCLUSIONS

Mobile application is a helpful tool to initiate and maintain self-management among diabetic patients and more improvements are necessary for the sake of easy use and effectiveness. Further high-quality qualitative study is needed to better understand requirements and using experience of diabetics, health care professionals or other stakeholders.
The Effect of Age on Electronic Health Literacy: Mixed-Method Study (Preprint)
Authors: Hsu Wan-Chen
Published: July 2018

BACKGROUND

The world’s internet penetration rate is increasing yearly; approximately 25% of the world’s population are internet users. In Asia, Taiwan has the fifth highest internet usage, and has an internet penetration rate higher than the world average. Electronic health (eHealth) literacy is the ability to read, understand, and utilize Web health information. eHealth literacy is gaining attention worldwide.

OBJECTIVE

This study aimed compare the differences in eHealth literacy between traditional college students (aged between 18 and 22 years) and older adult students (aged between 55 and 72 years). It also summarizes the experiences and performances of these 2 groups in terms of searching online health-related information.

METHODS

A mixed-method approach was used, including questionnaire surveys and interviews. A total of 208 respondents were interviewed: 65 traditional college students (31.3%) and 143 older adult students (68.7%). The results of the interviews were used to compare the eHealth literacy scores of the 2 groups.

RESULTS

There were significant differences in the overall eHealth literacy scores (t207=2.98; P=.001) and the functional eHealth literacy dimension (t207=12.17; P<.001). The findings showed a significant gap in eHealth literacy between the 2 groups. Most participants believed that online health information could be largely read and understood. However, they were skeptical about the quality of the information and noted that it consisted of either subjective judgments or objective standards.

CONCLUSIONS

Traditional college students preferred esthetically pleasing health information, whereas older adult students focused on its promotion. Furthermore, the first group often used websites for solving health problems, whereas the second group forwarded health information through communication software.
Efficacy and Outcomes of a Music-Based Emotion Regulation Mobile App in Distressed Young People: Randomized Controlled Trial (Preprint)
Authors: Hides Leanne , Dingle Genevieve , Quinn Catherine , Stoyanov Stoyan R , Zelenko Oksana , Tjondronegoro Dian , Johnson Daniel , Cockshaw Wendell , Kavanagh David J
Published: July 2018

BACKGROUND

Emotion dysregulation increases the risk of depression, anxiety, and substance use disorders. Music can help regulate emotions, and mobile phones provide constant access to it. The Music eScape mobile app teaches young people how to identify and manage emotions using music.

OBJECTIVE

This study aimed to examine the effects of using Music eScape on emotion regulation, distress, and well-being at 1, 2, 3, and 6 months. Moderators of outcomes and user ratings of app quality were also examined.

METHODS

A randomized controlled trial compared immediate versus 1-month delayed access to Music eScape in 169 young people (aged 16 to 25 years) with at least mild levels of mental distress (Kessler 10 score>17).

RESULTS

No significant differences between immediate and delayed groups on emotion regulation, distress, or well-being were found at 1 month. Both groups achieved significant improvements in 5 of the 6 emotion regulation skills, mental distress, and well-being at 2, 3, and 6 months. Unhealthy music use moderated improvements on 3 emotion regulation skills. Users gave the app a high mean quality rating (mean 3.8 [SD 0.6]) out of 5.

CONCLUSIONS

Music eScape has the potential to provide a highly accessible way of improving young people’s emotion regulation skills, but further testing is required to determine its efficacy. Targeting unhealthy music use in distressed young people may improve their emotion regulation skills.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry ACTRN12615000051549; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365974
Mobile Phone App for Self-Monitoring of Eating Rhythm: Field Experiment (Preprint)
Authors: Pentikäinen Saara , Tanner Hannu , Karhunen Leila , Kolehmainen Marjukka , Poutanen Kaisa , Pennanen Kyösti
Published: July 2018

BACKGROUND

Temporal aspects of eating are an integral part of healthy eating, and regular eating has been associated with good diet quality and more successful weight control. Unfortunately, irregular eating is becoming more common. Self-monitoring of behavior has been found to be an efficient behavioral change technique, but the solution should be simple enough to ensure long-lasting adherence.

OBJECTIVE

This study aimed to explore the influence of self-monitoring of daily eating pattern with mobile phone app on eating rhythm, eating behavior tendencies, and the underlying motives and attitudes related to eating.

METHODS

A mobile phone app, Button, was developed for effortless self-monitoring of eating rhythm. The feasibility of the app was tested in a 30-day intervention. The participants (N=74) recorded their eating occasions during the intervention by pressing a button in the app widget.

RESULTS

The average interval between meals increased (96 [SD 24] min during the first 10 days vs 109.1[SD 36.4] during the last 10 days) and the number of daily eating occasions decreased (4.9 [SD 0.9] during the first 10 days vs 4.4 [SD 0.9] during the last 10 days). The tendencies for cognitive restraint, emotional eating, and uncontrolled eating increased. Eating-related attitudes and motives remained largely unchanged.

CONCLUSIONS

These results indicate that a simple self-monitoring tool is able to draw a user’s attention to eating and is a potential tool to aid people to change their eating rhythm.
Achieving Sustainability and Scale-Up of Mobile Health Noncommunicable Disease Interventions in Sub-Saharan Africa: Views of Policy Makers in Ghana (Preprint)
Authors: Opoku Daniel , Busse Reinhard , Quentin Wilm
Published: July 2018

BACKGROUND

A growing body of evidence shows that mobile health (mHealth) interventions may improve treatment and care for the rapidly rising number of patients with noncommunicable diseases (NCDs) in sub-Saharan Africa (SSA). A recent realist review developed a framework highlighting the influence of context factors, including predisposing characteristics, needs, and enabling resources (PNE), for the long-term success of mHealth interventions. The views of policy makers will ultimately determine implementation and scale-up of mHealth interventions in SSA. However, their views about necessary conditions for sustainability and scale-up remain unexplored.

OBJECTIVE

This study aimed to understand the views of policy makers in Ghana with regard to the most important factors for successful implementation, sustainability, and scale-up of mHealth NCD interventions.

METHODS

Members of the technical working group responsible for Ghana’s national NCD policy were interviewed about their knowledge of and attitude toward mHealth and about the most important factors contributing to long-term intervention success. Using qualitative methods and applying a qualitative content analysis approach, answers were categorized according to the PNE framework.

RESULTS

A total of 19 policy makers were contacted and 13 were interviewed. Interviewees had long-standing work experience of an average of 26 years and were actively involved in health policy making in Ghana. They were well-informed about the potential of mHealth, and they strongly supported mHealth expansion in the country. Guided by the PNE framework’s categories, the policy makers ascertained which critical factors would support the successful implementation of mHealth interventions in Ghana. The policy makers mentioned many factors described in the literature as important for mHealth implementation, sustainability, and scale-up, but they focused more on enabling resources than on predisposing characteristics and need. Furthermore, they mentioned several factors that have been rather unexplored in the literature.

CONCLUSIONS

The study shows that the PNE framework is useful to guide policy makers toward a more systematic assessment of context factors that support intervention implementation, sustainability, and scale-up. Furthermore, the framework was refined by adding additional factors. Policy makers may benefit from using the PNE framework at the various stages of mHealth implementation. Researchers may (and should) use the framework when investigating reasons for success (or failure) of interventions.
CLIMATE CRISIS AND THE “WE”: An Essay in Deconstruction
Authors: Lane Jan-Erik
Published: July 2018

The new theory of abrupt climate change has yet to receive a response from those arguing for global policy coordination with the COP21 treaty or those who believe in country resilience. The only method to halt climate change with Hawking’s irreversibiity is to cut CO2s sharply now. But it will not happen, because of human regidity, opportunism with guile and institutional inertia. The global powers, acting for “WE” or “US” concentrate all attention upon petty matters.
EVALUATION OF ENZYMIC AND NON-ENZYMIC ANTIOXIDANT LEVELS IN VERNONIA CINEREA EXTRACTS
Authors: Abubakker Nishadh
Published: July 2018

Objective: The objective of this study was to evaluate the enzymic and non-enzymic antioxidant levels in various solvent extracts of Vernonia cinerea leaves.Methods: The fine powder of leaf (180 g) was extracted successively with methanol, ethanol, petroleum ether (40–60°C), benzene, acetone, ethyl acetate, chloroform, and aqueous in a Soxhlet extractor for 18 h. The extracts were concentrated under reduced pressure at low temperature (40– 50°C), and the extracts were analyzed for the antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), peroxidise, glutathione S-transferase (GST), glutathione peroxidase (GPx), polyphenol oxidase, glutathione (GSH) reductase, and glucose-6-phosphate dehydrogenase and non-enzymic antioxidants such as Vitamin A, C, E, reduced GSH, and total phenol.Results: Significant activities of enzymic antioxidants such as CAT (23.68 μ mole of H2O2 decomposed/min/mg protein, SOD (19.75 inhibition of 50% nitrite form/min/mg protein), and GST (73.28 μ mole of 1-chloro-2,4-dinitrobenzene conjugate formed/min) were observed higher in the methanolic extracts. Whereas, ethanolic extract exhibits maximum activity of GPx (1.054 μ mole of GSH utilized/min) and Px (102.1 μ mole of pyrogallol oxidized/ min/mg protein). Total GSH (172.3 μM/g), Vitamin E (23.76 μM/g), and total phenols were significantly predominant in the ethanolic extracts followed by methanol and ethyl acetate extracts.Conclusion: V. cinerea seems to be a promising plant in respect of its antioxidant potential, there is a lot more to be done to understand the mechanisms behind these effects as well as to employ them as possible therapeutic agents.
EFFECT OF HUMAN ADIPOSE-DERIVED STEM CELL IN COLLAGEN GEL ON RELATIVE EXPRESSION LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A OF DEEP DERMAL BURN HEALING
Authors: Sari Puji , Septiara Dwi Pratami , Junaidi Helsy , Yunaini Luluk , Pawitan Jenanne A
Published: July 2018

Objectives: The objectives of this research was to measure the relative expression levels of vascular endothelial growth Factor-A (VEGF-A) in the deep dermal burns treated with human adipose-derived stem cell (hADSC) in collagen gel in each observational day (days 7, 14, 21, and 28).Methods: This study used 20 male Sprague Dawley rats, divided into four groups of observation days. Each rat received three burn injuries and then given different treatments (hADSC in collagen gel, collagen gel, and control). Deep dermal burn injury on the dorsal was made by placing a metal plate with 250°C for 15 s. Relative expression level of VEGF-A measurement with quantitative reverse transcription polymerase chain reaction.Results: On the 7th day, the relative expression level of VEGF-A in the wound treated with hADSC in collagen gel was significantly different from the scaffold collagen and control group (p<0.05), whereas the control and scaffold collagen group was not significantly different. The relative expression level of VEFG-A in wound treated with hADSC in collagen gel, collagen gel only, and control was (mean±standard error of the mean) 17.93±4.37, 7.54±2.63, and 5.44±1.59, respectively. On the next observation days, the result showed that the relative expression level of VEGF-A was not significantly different between the three treatments. The relative expression level of VEGF-A has decreases from day 7 to 28 days. The decrease of VEGF-A relative expression level hADSC in collagen gel group was significantly different on the 7th day to the 21st and 28th days (p<0.05).Conclusion: The provision of hADSC in scaffold collagen increases the relative expression of VEGF-A early in the wound healing process compared to the without a hADSC group.
CLINICAL EVALUATION OF TRIPLE AND QUADRUPLE HELICOBACTER PYLORI ERADICATION THERAPY IN PEPTIC ULCER PATIENTS WITH DIFFERENT ABO BLOOD GROUP PHENOTYPES
Authors: Abdulridha Manal Khalid , Kutaif Rana Hussein , Kamal Yassir Mustafa , Najeeb Akram Ajeel
Published: July 2018

Objective: This study aimed to examine the pathological changes in gastric mucosa of Helicobacter pylori-infected peptic ulcer patients carrying different ABO phenotypes and to study the response to the 14 days’ standard triple therapy and 10 days’ quadruple therapy in peptic ulcer patients according to their ABO phenotypes.Methods: Interventional prospective randomized-controlled open-label study was performed on newly diagnosed patients with PUD. The H. pylori-positive patients were allocated into two major study groups in which they are subdivided according to ABO blood group phenotypes: Group 1 received standard H. pylori eradication triple therapy and Group 2 received standard H. pylori eradication quadruple regimen. Patients were monitored after 2 months for successful H. pylori eradication.Results: Chronic active gastritis was significantly high in patients carrying blood Group O phenotype (81.25%), while the atrophic gastritis and intestinal metaplasia were significantly high in patients carrying blood Group A phenotype (25.00% and 16.67%), respectively. 14 days’ triple therapy showed significantly lower eradication rate in H. pylori-infected peptic ulcer patients carrying blood Group O phenotype (p<0.01), meanwhile higher response was found among patients with blood Group B. 10 days’ quadruple therapy produced a significant high eradication rate in H. pylori-infected patients carrying blood Group O than those with blood Group A (p<0.01), but still both showed lower response compared to that in patients carrying blood Group B and AB phenotypes. Elderly patients showed significantly less healing efficacy than younger patients (p<0.01), and the least healing rate was noticed in female patients after both regimens.Conclusion: Lower eradication rate in H. pylori-infected was noticed in peptic ulcer patients carrying blood Group O mainly than those with other blood groups and particularly those with duodenal Ulceri. 10 days’ quadruple therapy showed significant higher eradication rate in H. pylori infection and a better ulcer healing efficacy.
KAIZEN AND LEAN IMPLEMENTATION IN PHARMACEUTICAL INDUSTRIES: A REVIEW
Authors: G Srinivasan , N Shah
Published: July 2018

Kaizen is one of the most commonly used words in all kind of industries. It has been implemented in organizations around the world as a way to improve production values while also improving employee morale and safety. The kaizen process brings about improvements that are small and incremental, and significant results can be seen only after a certain period of time. Many organizations across the world have adopted kaizen management philosophy and have successfully increased the efficiency of their end-to-end supply chains. With a focus on quality and regulatory compliance that are getting stringent day by day, pharmaceutical companies have been adopting these new strategies. This review focuses on basic aspects of Kaizen and Lean implementation and highlights few examples from pharmaceutical industry.
THE INFLUENCE OF HPC-L AND EUDRAGIT L30 D-55 ON DELAYED RELEASE OMEPRAZOLE MAGNESIUM MULTIPLE-UNIT PELLET SYSTEM
Authors: Mummidi Varalakshmi , Rezwana Shaik
Published: July 2018

Objective: The objective of the study is to develop optimum, stable, delayed release pellets of omeprazole magnesium (20.6 mg dose). Omeprazole magnesium is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ -ATPase at the secretory surface of the gastric parietal cell, which is orally administered drug, whereas omeprazole magnesium is degraded in stomach pH, so it is formulated as delayed release dosage form to absorb in intestinal pH.Methods: The formulation of delayed release pellets of omeprazole magnesium was developed by enteric film coating process varying the compositions of drug loading, barrier coating, and enteric coating using fluid bed processor. The prepared multiple pellets were filled into hard gelatin capsules as a single unit dosage forms.Results: The dissolution profile of formulation (F8) contains the efficient amount of hydroxypropyl cellulose-L and Eudragit L30 D55 leads to effective release of drug in 30 min. Fourier transform infrared and differential scanning colorimeter studies were conducted for the optimized formula to prove that the formula was not having incompatibility between the drug and excipients. The scanning electron microscopy studies were conducted to know the surface morphology of the pellets.Conclusion: It was concluded that optimized formulation (F8) shown good similarity with innovator. The results of the accelerated stability of final formulation revealed that storage conditions were excellent.
EMERGING NOVEL NANOPHARMACEUTICALS FOR DRUG DELIVERY
Authors: Wadhwa Abishek , Mathura Vashish , Lewis Shaila Angela
Published: July 2018

Nanotechnology is an area of growing public interest. Employing nanotechnology in the field of drug delivery has led to the advent of nanopharmaceuticals. Nanopharmaceuticals are bound to surmount various obstacles that the field of pharmacy is currently facing by offering various advantages thereby, a promising potential to formulate advanced medicines with fewer adverse effects. Extensive research is in place, thus instigating the development of novel drug delivery systems, such as carbon nanotubes, nanosponges, nano wafers, and nanofibers, to name a few. Since their inception, these nanopharmaceuticals have advanced significantly regarding their preparation strategy and scope of applications. This article aims to review the merits, limitations, and scope of these aforementioned delivery systems.
EFFECT OF DESENSITIZATION METHODS DURING THE EARLY MOBILIZATION PHASE IN POST-FRACTURE CONDITIONS OF UPPER EXTREMITY
Authors: Shah Poonam Sunil , Shinde Sandeep Babasaheb
Published: July 2018

Objectives: The objectives of the present study were to determine the effect of desensitization methods during early phase of mobilization in post-fracture conditions of upper extremity and to compare the effects of conventional physiotherapy methods and desensitization methods.Methods: A total of 30 subjects having fractures of upper extremity were assigned into two groups. Subjects included in Group A received conventional treatment (hot moist fomentation, mobilization, free exercises, resisted exercises, and strength training exercises). Group B received desensitization methods. The pre- and post-assessment is taken using visual analog scale, range of motion (ROM), manual muscle testing, and disabilities of the arm, shoulder and hand.Result: Desensitization showed significant improvement in ROM for elbow flexion (p=0.0427) (t=2.124) and in strength for shoulder flexion (p=0.0246) (t=2.376), shoulder extension (p=0.0246) (t=2.376), shoulder abduction (p=0.0246) (t=2.376)), shoulder adduction (p=0.0246) (t=2.376), and elbow extension (p=0.0472) (t=2.075) when compared to the conventional treatment, but the conventional treatment showed overall improvement in all outcome variables.Conclusion: Desensitization methods showed a significant effect on reducing pain and improving functional outcome.
THE ANTIBACTERIAL EVALUATION OF HALICLONA ASSOCIATED BACTERIA AND THE RELATING COMPOUNDS DERIVED FROM THE HOST
Authors: Murniasih Tutik , Putra Masteria Yunovilsa , Hadi Tri Aryono
Published: July 2018

Objective: The objective of this study was to investigate the active compounds derived from Haliclona sp. associated bacteria collected from Untung Jawa Island, Jakarta.Methods: The bacterial isolation, screening of antibacterial activity, purification, and prediction of potential compounds using liquid chromatography– mass spectroscopy/mass spectroscopy (LC–MS/MS) as well as 16S rDNA bacterial characterization were conducted.Results: The potential extract of bacterial strain UJ.17.10-4 showed the highest anti-Gram-positive bacteria. The 16S rDNA gene of this strain had 99% similarity with the actinobacteria Agromyces tropicus. Chemical separation of supernatant extract yielded 13 potent fractions. Identification of antibacterial compounds contained in active fractions using LC-MS/MS were halistanol sulphate C([M+H]+:703), cyclic bis-1,3- dialkylpyridinium([M+H]+: 213.72). In previous research reported that these compounds were isolated from Haliclona sponge and showed anticancer activity.Conclusion: This result supported the ideas that A. tropicus plays an important role in synthesizing, halistanol sulfate C, haliclorensin, and cyclic bis- 1,3-dialkylpyridinium metabolite derived from the host.
EVALUATION OF ANTIOXIDANT, ANTIBACTERIAL, AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF ETHYL ACETATE EXTRACT OF STREPTOMYCES OMIYAENSIS SCH2
Authors: Tangjitjaroenkun Janpen
Published: July 2018

Objective: The aim of this study was to evaluate the antibacterial and antioxidant properties of ethyl acetate extract of Streptomyces omiyaensis SCH2. The chemical constituents of the extract were investigated using gas chromatography-mass spectrometry (GC-MS).Methods: Secondary metabolites from S. omiyaensis were produced by submerge fermentation using ISP2 medium with 3% NaCl (w/v) for 21 days. The culture filtrate was extracted with ethyl acetate. The chemical constituents were detected in the GC-MS analysis. Antibacterial activity was performed using disc diffusion and broth microdilution methods. Antioxidant activity was evaluated by determining the reducing power capacity and free radical scavenging assays.Results: The GC-MS analysis of the SCH2 extract revealed the presence of four compounds. The main constituents were 2-phenylacetamide (79%). The extract exhibited the highest zone of inhibition against some pathogenic bacteria such as Enterobacter cloacae, Klebsiella pneumoniae, and Bacillus subtilis. In addition, the lowest minimum inhibitory concentration (IC) and minimum bactericidal concentration values of extract were obtained for E. cloacae (0.125 and 4 mg/ml). The extract showed antioxidant potential with IC50 values of 2.078.13±24.58 μg/ml and 475.74±4.56 μg/ml for 2,2-diphenyl-1-picryl-hydrazyl and 2,2′-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] assays, respectively. The ferric reducing antioxidant power value of extract was 110.36±1.75 mmol FeSO4.7H2O/g extract.Conclusion: This study indicated that S. omiyaensis extract possesses antibacterial and antioxidant activities. GC-MS analysis revealed the presence of major chemical constituents, acetamide, and pyrrolopyrazine which could be responsible for the biological activities. S. omiyaensis extract could be used as a potential of natural antibacterial and antioxidant agents for pharmaceutical and medical applications.
DEVELOPMENT AND IN VIVO EVALUATION OF MUCOADHESIVE MICROSPHERES USING PIRENZEPINE
Authors: P Kanteepan , Dvrn Bhikshapathi
Published: July 2018

Objective: The current investigation objective was to fabricate gastroretentive mucoadhesive microspheres of pirenzepine and to investigate the pharmacokinetic parameters of optimized formulation in comparison with a marketed product.Methods: Pirenzepine mucoadhesive microspheres prepared using ionotropic gelation technique. Evaluation parameters and characterization such as Fourier transform infrared (FTIR) and scanning electron microscopy were performed. In vivo bioavailability studies were conducted in rabbits. The technique used was found to be handling easy, inexpensive, and reproducible process.Results: Among the total 14 formulations, M13 formulation was optimized and showed free flowing with good packability. FTIR studies investigated incompatibility were not observed between drug and excipients. The optimized formulation (M13) showed best cumulative percentage drug release of pirenzepine up to 99.07±0.17% within 12 h whereas marketed product displayed the drug release of 95.23±0.21% within 1 h. The release mechanism from microspheres followed the zero-order and Korsmeyer–Peppas model (R2=0.951 and 0.994), respectively. Optimized formulation (M13) was stable at 40°C±2°C/75% RH±5% RH for 6 months. Form in vivo studies, the optimized formulation bioavailability was much higher than the marketed product.Conclusion: Microspheres would be a promising drug delivery system could play a potentially significant role in pharmaceutical drug delivery in a controlled manner for an extended period of time for effective management of gastritis.
SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF AMILORIDE HYDROCHLORIDE AND FUROSEMIDE IN A PHARMACEUTICAL DOSAGE FORM USING REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD
Authors: Shaik Javed S , Rao Nutan N
Published: July 2018

Objective: The present study describes the stability indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous estimation of amiloride hydrochloride and furosemide in pharmaceutical dosage forms.Methods: The proposed RP-HPLC method was developed using Shimadzu LC-2030 HPLC system equipped with UV detector, and chromatographic separation was carried on Shim-pack C18 (250 mm×4.6 mm, 5 μ) column at a flow rate of 1 ml/min and the runtime was 4min. The mobile phase consisted of water and acetonitrile in the ratio of 35:65, and elements were scanned using a UV detector at 281 nm.Results: The retention time of amiloride hydrochloride and furosemide was found to be 1.92 min and 3.14min, respectively. Linearity was found to be 12–28 ppm for amiloride hydrochloride and 96–224 ppm for furosemide, respectively. Limit of detection and limit of quantification for amiloride hydrochloride were 0.381 ppm and 1.156 ppm and for furosemide were 2.00 ppm and 6.068 ppm, respectively.Conclusion: The stability indicating method was developed by subjecting the drugs to stress conditions such as acid and base hydrolysis, oxidation, humidity, photolytic, and thermal degradation, and the degraded products formed were resolved successfully from the samples.
A REVIEW OF BENZOPYRAN DERIVATIVES IN PHARMACOTHERAPY OF BREAST CANCER
Authors: Piyush Kumar , Kuldeep Singh , Md. Azizur Rahman , Misbahul Hasan Syed , Pranay Wal
Published: July 2018

One of the naturally occurring compounds containing oxygen moiety is benzopyran. Depending on its substitution pattern, different biological effects are shown. The benzopyran ring system is present in many natural products (such as genistein, hesperidin, and warfarin) as well as synthetic products. It displays pharmacological properties such as antitumor, anti-HIV, antimicrobials, anti-inflammatory, and anticoagulants. The sufficient literature support and the fact that benzopyran has potential as a pharmacophore particularly as anti-breast cancer, etc, current research seemed pertinent keeping in view the mechanism of anti-breast cancer activity. Therefore, the objective of this review is to focus on important benzopyran analogs with anti-breast cancer activity and highlight their mechanisms of action.
On the lexical pragmatics Dictionary of Russian language
Authors: Кузьмина Елена , Kuzmina Elena , Васильева Ольга , Vasilyeva Olga , Пурицкая Елизавета , Puritskaya Elizaveta
Published: July 2018

The article outlines the conception of the lexical pragmatics Dictionary of Russian language that was formulated while working on research project “Vocabulary of Russian language with a pragmatic component of semantics”. The pragmatic component of the word is a phenomenon in which the national specifics of language is manifested. Those implicit elements of meaning (including evaluative, emotive, expressive, cultural connotations, etc.) that constitute the pragmatic component of the word often cause communicative mistakes in the speech practice of native speakers and foreigners. Successful communication requires possession of the information about pragmatic properties of the words, i.e., about pragmatic competence. The article determines the novelty of this Dictionary and its correlation to the preceding lexicographic tradition, the Dictionary tasks, sources, and main parameters (aspects) of the description of a lexical unit.
Saturated Iteration of Neighborhood Averaging Filter Algorithm For Kinect Structural Noise Eliminator For Wild Thumper
Authors: Kurniawan Aditya , Wardani Kholilatul
Published: July 2018

A contemporary study (Andersen, 2012) on the Kinect sensor as a visual sensor device for robots explains that the sensor has some fundamental flaws. Among them there is a shadow on the results of sensing edge objects that will affect the process of recognition of shape (shape recognition) spatially. If the Kinect sensor is used in the robot vision navigation system, the sensor may lead to errors in the robot's decision on the shape of the object being sensed. The experiment was aimed to measure the saturation iteration level for the Localized Neighborhood-Averaging method in its effect on the shadow thickness (structural noise) produced by kinect sensors. Robot model that will be used for testing is the robot Wild Thumper 4WD. The kinect sensor is conditioned to capture a square black object measuring 10cm x 10cm perpendicular to a homogeneous background (white with RGB code 255,255,255). The result of kinect sensor data will be taken using Visual Basic 6.0 program periodically by repeating the Localized Neighborhood-Averaging method 1x up to 5x iteration. Observation will be done by looking at the similarity of edge slices of objects captured by Kinect sensors. Saturated iteration Neighborhood-Averaging filter on pixel noise generated by kinect is on the 3rd iteration based on observation of edge section with 2 iteration ratio showing no change in noise thickness. The noise thread at the 2nd and 3rd iterations has the same contours based on the Coefficient of Variation calculations applied to both data. The use of filters is by filter masking 3x3 matrix size. It is expected that further research can be developed on the size of 5x5 or more masking filters in the hope of having a better saturation iteration tolerance result.
Comparison of Some Methods for the Elderly Patient Telemonitoring System
Authors: Setiawan Hendra , Wahyuni Elvira Sukma
Published: July 2018

This paper analyzes some research results related to patient telemonitoring system. The main objective is to collect many useful information for telemonitoring implementation and its development in the future. Telemonitoring system is focused on fall detection that generally occur prior to critical condition. There are 14 research results that discussed in this paper which have been published from 2013 to 2017. Those researches are grouped into three types i.e. intrusive, non-intrusive and mixed. Analysis is done on aspects of the comfort, complexity, cost, accuracy, and coverage. Furthermore, based on those information, a study of application feasibility is done for elderly patients in Indonesia. The result shows that the non-intrusive method using the camera or access point are the most appropriate system for the elderly fall detection.
Impact of H-Index Toward Citations Using Linear Regression on Science and Technology Index
Authors: Muriyatmoko Dihin , Rady Putra Lalu Ganda
Published: July 2018

Number of Journals in Indonesia is quite a lot and various disciplines. Until March 15, 2018, registered 50,889 online and print ISSN by Indonesian Institute of Science (LIPI). The government through Ministry of Research, Technology, and Higher Education of Republic Indonesia (Kemenristekdikti) set regulated on journal index, that is Science and Technology Index (SINTA) assigned to rank quality content and management divided by six categories called S1 to S6 which of the data is taken from Google Scholar and Scopus. This research applies S1 that these journals are accredited “A” by Kemenristekdikti and or index by Scopus. That’s data is shown ranking by sorted based on h-index and citations. S1 shown that journal which has highest h-index uncertain have highest citations too, even some have zeroes. That’s data on S1 become strange and awkward when compared with S2 to S6 because some value of h-index and citations S1 is lower than S2 to S6. This research focus to find how strong correlation or impact h-index toward citations using linear regression. The test result shows that value of Multiple R = 0.78 indicates the correlative is very close, a value of R Square = 0.61 indicates the impact of h-index toward citations achieve 61% and the rest 39% affected by others factor.
Design of Application On/Off Electronic Device with Markov Model Using Speech Recognition on Android
Authors: Widyatmoko Rochman , Purwantoro E. S. G Sugeng , Syahbana S Yoanda Alim
Published: July 2018

Electronic devices are supported by a switch that is used to turn the device on and off. Manually pressed switches with distances between remote switches to cause less efficiency in saving human time and manpower. This can be solved by building a system to control electronic devices automatically. The system uses human voice commands to turn on and off electronic devices. The command will be processed into text by the Google Voice Speech Recognition library. The Android app sends human commands that have been processed by Arduino Uno R3 microcontroller. Commands are obtained after the text and data in the database are processed using the Markov Model algorithm. Communication between Android smartphone and microcontroller will be designed through a WIFI network. This system is tested based on noise level with data accuracy level with noise 0-45 dB and obtained 65% result. Based on the test response time obtained that the noise level 0-45 dB obtained results of 5.41 seconds. Based on the test results from the scenario, it can be concluded that the lower the noise generated, the better the system will also respond to commands. From the test suitability get value X = 1, meaning that the system is suitability with error rate 0. In testing accuracy to view status function get value 0 with error level 0. Testing of Markov model algorithm yields the calculated 0.125 algorithms manually and code for each command
Acquisition of Email Service Based Android Using NIST
Authors: Umar Rusydi , Riadi Imam , Muthohirin Bashor Fauzan
Published: July 2018

Email is one of the results of the development of information and communication technology. Email is widely used to exchange information by sending and receiving data, such as document files, images, correspondence and others. With the development of technology and information causing crimes in communicating also growing, the perpetrators of cyber crime commonly referred to as cybercrime. Any crime committed by cybercrime will surely leave the evidence, in this study will make the acquisition of android-based email using the method of national institute of standards and technology (NIST). The results obtained IP address of the sender's email header as digital evidence.