bluuebunny/crossref_metadata_2025 huggingface dataset:
Solutions for one‐dimensional consolidation of unsaturated soil with general boundary conditions subjected to time‐dependent load
Authors: Niu Jiajun , Ling Daosheng , Zhu Song , Gong Shilin , Shan Zhendong
Published: April 2021

Based on the governing equations proposed by Fredlund and Hasan, this paper firstly establishes a mathematical model for one‐dimensional consolidation of single‐layer unsaturated soil with general boundary conditions, arbitrary initial conditions and time‐dependent external load. Then the eigenfunction expansion method is used to derive series solutions for excess pore water pressure and excess pore air pressure in time domain directly. It can be inferred that the series solutions in this paper for one‐dimensional consolidation of unsaturated soil are more general compared with previous researches, due to the generality of boundary conditions and time‐dependent load. They could be degenerated into solutions for one‐dimensional consolidation of unsaturated soil in various conditions. Finally, comparisons with results from previous literatures are made to validate the general series solutions in this research. More examples are provided to illustrate the consolidation behaviors of unsaturated soil with different impeded drainages on air and water phases at the boundary, and different types of external load.
Exposure–response modeling of peficitinib efficacy in patients with rheumatoid arthritis
Authors: Toyoshima Junko , Kaibara Atsunori , Shibata Mai , Kaneko Yuichiro , Izutsu Hiroyuki , Nishimura Tetsuya
Published: April 2021

The aim was to analyze the relationship between peficitinib exposure and efficacy response according to American College of Rheumatology (ACR) 20 criteria and 28‐joint disease activity score based on C‐reactive protein (DAS28‐CRP) in rheumatoid arthritis (RA) patients, and to identify relevant covariates by developing exposure–response models. The analysis incorporated results from three multicenter, placebo‐controlled, double‐blind studies. As an exposure parameter, individual post hoc pharmacokinetic (PK) parameters were obtained from a previously constructed population PK model. Longitudinal ACR20 response rate and individual longitudinal DAS28‐CRP measurements were modeled by a non‐linear mixed effect model. Influential covariates were explored, and their effects on efficacy were quantitatively assessed and compared. The exposure–response models of effect of peficitinib on duration‐dependent increase in ACR20 response rate and decrease in DAS28‐CRP were adequately described by a continuous time Markov model and an indirect response model, respectively, with a sigmoidal Emax saturable of drug exposure in RA patients. The significant covariates were DAS28‐CRP and total bilirubin at baseline for the ACR20 response model, and CRP at baseline and concomitant methotrexate treatment for the DAS28–CRP model. The covariate effects were highly consistent between the two models. Our exposure–response models of peficitinib in RA patients satisfactorily described duration‐dependent improvements in ACR20 response rates and DAS28‐CRP measurements, and provided consistent covariate effects. Only the ACR20 model incorporated a patient's subjective high expectations just after the start of the treatment. Therefore, due to their similarities and differences, both models may have relevant applications in the development of RA treatment.

Clinical trial registration

NCT01649999 (RAJ1), NCT02308163 (RAJ3), NCT02305849 (RAJ4).
Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline
Authors: Dashwood Alexander , Cheesman Elizabeth , Wong Yee Weng , Haqqani Haris , Beard Nicole , Hay Karen , Spratt Melanie , Chan Wandy , Molenaar Peter
Published: April 2021

Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β1–adrenoceptor (AR) agonist (−)‐noradrenaline and spontaneous contractions. Left and right ventricular trabeculae from 13 explanted failing hearts, and trabeculae from 58 right atrial appendages of non‐failing hearts, were incubated with or without a single concentration of OM for 120 min. Time to peak force (TPF) and 50% relaxation (t50%) were recorded. In other experiments, trabeculae were observed for spontaneous contractions and cumulative concentration‐effect curves were established to (−)‐noradrenaline at β1‐ARs in the absence or presence of OM. OM prolonged TPF and t50% in ventricular trabeculae (600 nM, 2 µM, p < .001). OM had no significant inotropic effect but reduced time dependent deterioration in contractile strength compared to control (p < .001). OM did not affect the generation of spontaneous contractions. The potency of (−)‐noradrenaline (pEC50 6.05 ± 0.10), for inotropic effect, was unchanged in the presence of OM 600 nM or 2 µM. Co‐incubation with (−)‐noradrenaline reduced TPF and t50%, reversing the negative diastolic effects of OM. OM, at both 600 nM and 2 µM, preserved contractile force in left ventricular trabeculae, but imparted negative diastolic effects in trabeculae from human failing heart. (−)‐Noradrenaline reversed the negative diastolic effects, co‐administration may limit the titration of inotropes by reducing the threshold for ischemic side effects.
Direct healthcare professional communications: A quantitative assessment study
Authors: Alsaleh Hajar , Alshammari Thamir M.
Published: April 2021

A retrospective observational study evaluated the direct healthcare professional communication (DHPC) letters disseminated by the Saudi Food and Drug Authority (SFDA) and their compliance with the pharmacovigilance guidelines. The study was utilized all DHPC letters available on the SFDA website, which is intended to communicate drug safety information to healthcare professionals (HCPs). Then, the letters were evaluated based on DHPC letter requirements approved in the European Medicines Agency (EMA) pharmacovigilance guidelines. Statistical analyses were conducted utilizing statistical analysis software (SAS® version 9.4). In June 2020, 169 letters were retrieved from the SFDA website. Most of the letters had the marketing authorization holder's logo (97%) and mentioned the date of letter issuance (98.8%). The most frequently discussed safety issues were hyperkalemia risk associated with combining renin–angiotensin–aldosterone system (RAAS) medications (10.6%) and cardiac risks (9%). Antineoplastic and immunosuppressant classes were associated with a majority of DHPC letters (15% for each category). A significant percentage of DHPC letters (10%) did not mention an agreement statement with SFDA, and 42 letters did not include marketing authorization holders (MAHs) contact information. The qualified persons responsible for pharmacovigilance and medical directors had signed most of the DHPC letters (51% and 46%, respectively). Many letters mentioned the details of reporting information to both SFDA and an MAH (82%). Moreover, 66% of the DHPC letters presented safety information within the 2‐page limit. In conclusion, the DHPC letters disseminated by MAHs in Saudi Arabia have an acceptable level of compliance with the guidelines.
Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir
Authors: Mutiti Chenai Sheilla , Kapungu Nyasha Nicole , Kanji Comfort Ropafadzo , Stadler Nadina , Stingl Julia , Nhachi Charles , Hakim James , Masimirembwa Collen , Thelingwani Roslyn Stella
Published: April 2021

We conducted a clinical study to determine the effect of efavirenz and ritonavir on the pharmacokinetics of R‐ and S‐PZQ in healthy male participants. This was toward evaluating the risk of drug‐drug interactions, which may occur after PZQ administration to HIV patients on efavirenz or ritonavir containing regimens. A non‐randomized, open‐label, single‐dose, one sequence crossover study with 2 arms was conducted. We gave 26 healthy volunteers a single oral dose of 40 mg/kg PZQ followed by a daily oral dose of either 400 mg efavirenz or 100 mg ritonavir for 14 consecutive days. On day 14, they ingested a single 40 mg/kg dose of PZQ. We measured plasma levels up to 12 h on day 1 and day 14. Samples were analyzed by LC‐MS. Pharmacokinetic analysis was conducted in WinNonlin to determine the primary endpoints (plasma T1/2, Cmin, and AUC). Efavirenz had a significant effect on the pharmacokinetics of PZQ (p < .05), reducing the AUC by 4‐fold (1213.15 vs. 281.35 h·ng/ml for R‐PZQ and 5669 vs. 871.84 h·ng/ml for S‐PZQ). Ritonavir had no significant effect on R‐PZQ but increased the AUC 2‐fold for S‐PZQ (p < .05) (4154.79 vs. 7291.05 h·ng/ml). Using PZQ in HIV patients needs investigation, as there is a risk of both treatment failure and adverse effects because of induction and inhibition, respectively.
Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties
Authors: Jadhav Ashwini Khanderao , Karuppayil Sankunny Mohan
Published: April 2021

Andrographis paniculata is home to a rich variety of molecules especially andrographolide and its derivatives. Clinical properties of the andrographolide are multifarious and include: analgesic, antipyretic, antiretroviral, antiproliferative, antimalarial, antithrombotic, antihyperglycemic, antiurolethial, antilesihmaniasis, hepatoprotective, immune‐modulatory, protective against alcohol induced toxicity and cardioproetcive activity and anticancer activity. Andrographolide, neoandrographolide, dehydroandrographolide and several natural and synthetic derivatives of it: 14‐deoxy‐11,12‐didehydroandrographolide and 14‐deoxyandrographolide, dehydroandrographolide succinic acid monoester (DAMS), 14‐ά‐lipoyl andrographolide (AL‐1), 14‐acetyl‐3,9‐isopropyl‐ideneandrographolide, 14‐acetylandrographolide, 3,14,19‐triacetylandrographolide, and 3,9‐isopropyl‐idene andrographolide, are shown to possess significant antiviral activity against HIV, influenza A, HBV, HCV, HPP and HSV. Studies on SARS CoV 2 is restricted to in silico molecular docking studies on viral targets and selected host target proteins. The main targets of andrographolide and its derivatives are fusion and adsorption of virus to the host cell, binding to viral receptor and co‐receptor, enzymes involved in DNA/RNA/Genome replication by the virus, translation, post‐translation and reverse transcription. Andrographolide as a drug is yet to reach its full therapeutic potential since this molecule shows low bioavailability. Andrographolide therapy is in need of an appropriate delivery system that may increase its bioavailability. Further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.
Place‐based identity: A model
Authors: Cain Elise J.
Published: April 2021

This chapter focuses on the topic of place‐based identity, including how place has both objective and subjective components that are best understood within the system of urbanormativity. This model is then situated within the Reconceptualized Model of Multiple Dimensions of Identity and implications for student affairs practices are shared.
Treatment for tetanus applying Kampo medicine: Administration of shakuyakukanzoto
Authors: Nakae Hajime , Irie Yasuhito , Satoh Kasumi , Kitamura Toshiharu , Kameyama Koumei , Nara Tasuku , Okuyama Manabu
Published: April 2021

Aim

Severe tetanus can be fatal, even with the latest drug treatments and artificial respiration. Nevertheless, combining Western and Kampo medicine may be beneficial for tetanus treatment.

Methods

We summarise the benefits of applying Kampo medicine in tetanus, especially referring to using shakuyakukanzoto (SKT) from the aspect of controlling myospasms. SKT is a Kampo formula used for the treatment of pain associated with sudden myospasms.

Results

SKT, kakkonto, daisaikoto, and daijokito have been used to successfully treat patients with generalised convulsions caused by generalised tetanus, without the use of a muscle relaxant. However, hypokalaemia, oedema, and hypertension caused by pseudo‐aldosteronism, which may result from an adverse reaction to licorice, should be monitored when using SKT.

Conclusion

A large randomised controlled trial may be necessary to establish a treatment for tetanus using both Western and Kampo medicines.
Searching for heavy Higgs in supersymmetric final states at the LHC
Authors: Adhikary Amit , Bhattacherjee Biplob , Godbole Rohini M. , Khan Najimuddin , Kulkarni Suchita
Published: April 2021

Abstract

In this work, we analyse and demonstrate possible strategies to explore extended Higgs sector of the Minimal Supersymmetric Standard Model (MSSM). In particular we concentrate on heavy Higgs decays to electroweakinos. We analyse the Higgs to electroweakino decays in the allowed MSSM parameter space after taking into account 13 TeV LHC searches for supersymmetric particles and phenomenological constraints such as flavour physics, Higgs measurements and dark matter constraints. We explore some novel aspects of these Higgs decays. The final states resulting from Higgs to electroweakino decays will have backgrounds arising from the Standard Model as well as direct electroweakino production at the LHC. We demonstrate explicit kinematical differences between Higgs to electroweakino decays and associated backgrounds. Furthermore, we demonstrate for a few specific example points, optimised analysis search strategies at the high luminosity LHC (HL-LHC) run. Finally, we comment on possible search strategies for heavy Higgs decays to exotic final states, where the lightest chargino is long lived and leads to a disappearing track at the LHC.
Modularity of the displacement coefficients and complete plate theories in the framework of the consistent-approximation approach
Authors: Meyer-Coors Michael , Kienzler Reinhold , Schneider Patrick
Published: April 2021

Starting from the three-dimensional theory of linear elasticity, we arrive at the exact plate problem by the use of Taylor series expansions. Applying the consistent-approximation approach to this problem leads to hierarchic generic plate theories. Mathematically, these plate theories are systems of partial-differential equations (PDEs), which contain the coefficients of the series expansions of the displacements (displacement coefficients) as variables. With the pseudo-reduction method, the PDE systems can be reduced to one main PDE, which is entirely written in the main variable, and several reduction PDEs, each written in the main variable and several non-main variables. So, after solving the main PDE, the reduction PDEs can be solved by insertion of the main variable. As a great disadvantage of the generic plate theories, there are fewer reduction PDEs than non-main variables so that not all of the latter can be determined independently. Within this paper, a modular structure of the displacement coefficients is found and proved. Based on it, we define so-called complete plate theories which enable us to determine all non-main variables independently. Also, a scheme to assemble Nth-order complete plate theories with equations from the generic plate theories is found. As it turns out, the governing PDEs from the complete plate theories fulfill the local boundary conditions and the local form of the equilibrium equations a priori. Furthermore, these results are compared with those of the classical theories and recently published papers on the consistent-approximation approach.
Simulation of the laser-material interaction of ultrashort pulse laser processing of silicon nitride workpieces and the key factors in the ablation process
Authors: Soltani Babak , Hojati Faramarz , Daneshi Amir , Azarhoushang Bahman
Published: April 2021

Understanding the laser ablation mechanism is highly essential to find the effect of different laser parameters on the quality of the laser ablation. A mathematical model was developed in the current investigation to calculate the material removal rate and ablation depth. Laser cuts were created on the workpiece with different laser scan speeds from 1 to 10 mm s−1by an ultrashort pulse laser with a wavelength of about 1000 nm. The calculated depths of laser cuts were validated via practical experiments. The variation of the laser power intensity on the workpiece’s surface during laser radiation was also calculated. The mathematical model has determined the laser-material interaction mechanism for different laser intensities. The practical sublimation temperature and ablated material temperature during laser processing are other data that the model calculates. The results show that in laser power intensities (IL) higher than 1.5 × 109W cm−2, the laser-material interaction is multiphoton ionisation with no effects of thermal reaction, while in lower values ofIL, there are effects of thermal damages and HAZ adjacent to the laser cut. The angle of incidence is an essential factor in altering incidentILon the surface of the workpiece during laser processing, which changes with increasing depth of the laser cut.
Detrusor underactivity prevalence and risk factors according to different definitions in women attending urogynecology clinic
Authors: D’Alessandro Gloria , Palmieri Stefania , Cola Alice , Barba Marta , Manodoro Stefano , Frigerio Matteo
Published: April 2021

Introduction and hypothesis

There is still no consensus on definitions of detrusor underactivity; therefore, it is difficult to estimate the prevalence. The primary objective of the study was to evaluate the prevalence of detrusor underactivity in a cohort of patients with pelvic floor disorders according to different proposed urodynamics definitions. The secondary objectives were to estimate the association between detrusor underactivity and symptoms, anatomy and urodynamic findings and to build predictive models.

Methods

Patients who performed urodynamic evaluation for pelvic floor disorders between 2008 and 2016 were retrospectively analyzed. Detrusor underactivity was evaluated according to Schafer’s detrusor factor, Abrams’ bladder contractility index and Jeong cut-offs. The degree of concordance between each method was measured with Cohenʼs kappa, and differences were tested using Student’s t test, Wilcoxon test and Pearson’s chi-squared test.

Results

The prevalence of detrusor underactivity among a cohort of 2092 women, concerning the three urodynamic definitions, was 33.7%, 37.0% and 4.1%, respectively. Age, menopausal status, voiding/bulging symptoms, anterior and central prolapse, first desire to void and positive postvoid residual were directly related to detrusor underactivity. Conversely, stress urinary incontinence, detrusor pressures during voiding and maximum flow were inversely associated. Final models for detrusor underactivity resulted in poor accuracy for all considered definitions.

Conclusions

The prevalence of detrusor underactivity varies depending on the definition considered. Although several clinical variables resulted as independent predictors of detrusor underactivity, instrumental evaluation still plays a key role in the diagnosis.
Diagnosis and treatment delay of head and neck cancers during COVID-19 era in a tertiary care academic hospital: what should we expect?
Authors: De Luca Pietro , Bisogno Antonella , Colacurcio Vito , Marra Pasquale , Cassandro Claudia , Camaioni Angelo , Cassandro Ettore , Scarpa Alfonso
Published: April 2021

Background

Since the spreading of SARS-CoV-2 from China, all deferrable medical activities have been suspended, to redirect resources for the management of COVID patients. The goal of this retrospective study was to investigate the impact of COVID-19 on head and neck cancers’ diagnosis in our Academic Hospital.

Methods

A retrospective analysis of patients treated for head and neck cancers between March 12 and November 1, 2020 was carried out, and we compared these data with the diagnoses of the same periods of the 5 previous years.

Results

47 patients were included in this study. We observed a significative reduction in comparison with the same period of the previous 5 years.

Conclusions

Our findings suggest that the COVID-19 pandemic is associated with a decrease in the number of new H&N cancers diagnoses, and a substantial diagnostic delay can be attributable to COVID-19 control measures.
MicroRNAs in the aqueous humor of patients with different types of glaucoma
Authors: Kosior-Jarecka Ewa , Czop Marcin , Gasińska Karolina , Wróbel-Dudzińska Dominika , Zalewski Daniel P. , Bogucka-Kocka Anna , Kocki Janusz , Żarnowski Tomasz
Published: April 2021

Purpose

The aim of the study was to compare the frequency and the level of expression of selected miRNAs in the aqueous humor of patients with various types of glaucoma.

Methods

The studied group consisted of 42 patients with glaucoma: 19 with primary open-angle glaucoma (POAG), 14 with pseudoexfoliation glaucoma (PEXG), 9 with primary angle closure glaucoma (PACG), and the control group of 36 patients with senile cataract without glaucoma. The real-time polymerase chain reaction method was used to analyze the expression of miRNAs.

Results

There were no significant differences in the frequency and the level of miRNA expression between various types of glaucoma. There was a tendency for hsa-miR-6722-3p and hsa-miR-184 to be expressed more frequently in PEXG and hsa-miR-1260b in POAG. The expression levels of hsa-miR-1260b and hsa-miR-6515-3p were correlated with age in POAG. Target annotation and functional analyses showed that genes targeted by the most frequently expressed miRNAs (hsa-miR-1202, -1260b, -184, -187-5p, -6515-3p, -6722-3p, and hsa-mir-4634) are involved mainly in response to hypoxia, cardiovascular system development, and apoptosis.

Conclusion

Hsa-miR-1260b was the most abundantly expressed among studied miRNAs and may be a potential biomarker of clinical status in PEXG and PACG.
Elterliche Reaktionen auf kindliche Schmerzen
Authors: Wallrath Maren K. , Geremek Adam , Rubel Julian , Lindner Clemens , Hechler Tanja
Published: April 2021

Hintergrund

Elterliche kognitiv-affektive und verhaltensbezogene Reaktionen können die Chronifizierung von kindlichen Schmerzen beeinflussen. Unklar ist, ob Mütter und Väter unterschiedlich reagieren und inwieweit Top-down- (elterliche Somatisierung, Angstsymptome) und Bottom-up-Variablen (kindliche schmerzbezogene Beeinträchtigung, Angstsymptome) die elterlichen Reaktionen modulieren.

Ziele der Arbeit

(1) Vergleich der Somatisierung, Angstsymptome und elterlichen Reaktionen (Katastrophisieren, Zuwendung) von Müttern und Vätern chronisch schmerzkranker Kinder und (2) Untersuchung des Einflusses von Top-down- und Bottom-up-Variablen auf die elterlichen Reaktionen.

Methode

Eltern-Kind-Triaden (Kind, Mutter, Vater; je N = 21, Gesamt‑N = 63; Kinder: 50 % weiblich, 11–19 Jahre, ∅15,14 Jahre) wurden während einer kinder- und jugendpsychiatrischen Behandlung ihrer chronischen Schmerzen hinsichtlich der kindlichen Schmerzen und Angstsymptome, elterlicher Somatisierung und Angstsymptome und elterlichen Reaktionen mit validierten Fragebögen erfasst.

Ergebnisse

Mütter und Väter unterschieden sich nicht in Somatisierung, Angstsymptomen und Reaktionen. Eltern katastrophisierten stärker, wenn ihre Kinder sowohl unter Angstsymptomen als auch unter stärkerer schmerzbezogener Beeinträchtigung litten. Elterliche Zuwendung war verstärkt, wenn Eltern selbst Angstsymptome angaben. Jüngere Kinder und Mädchen erhielten mehr Zuwendung.

Diskussion

Im Einklang mit vorherigen Studien zeigt sich, dass elterliche und kindliche Angstsymptome, nicht aber das elterliche Geschlecht als modulierende Faktoren der elterlichen maladaptiven Reaktionen eine Rolle spielen. Dies sollte in Prävention und Therapie von Kindern mit chronischen Schmerzen und deren Bezugspersonen berücksichtigt werden.
Diophantine equations in separated variables and polynomial power sums
Authors: Fuchs Clemens , Heintze Sebastian
Published: April 2021

We consider Diophantine equations of the shape $$ f(x) = g(y) $$

f
(
x
)
=
g
(
y
)

, where the polynomials f and g are elements of power sums. Using a finiteness criterion of Bilu and Tichy, we will prove that under suitable assumptions infinitely many rational solutions (x, y) with a bounded denominator are only possible in trivial cases.
Review: Hydrogeology of weathered crystalline/hard-rock aquifers—guidelines for the operational survey and management of their groundwater resources
Authors: Lachassagne Patrick , Dewandel Benoît , Wyns Robert
Published: April 2021

Hard rocks or crystalline rocks (i.e., plutonic and metamorphic rocks) constitute the basement of all continents, and are particularly exposed at the surface in the large shields of Africa, India, North and South America, Australia and Europe. They were, and are still in some cases, exposed to deep weathering processes. The storativity and hydraulic conductivity of hard rocks, and thus their groundwater resources, are controlled by these weathering processes, which created weathering profiles. Hard-rock aquifers then develop mainly within the first 100 m below ground surface, within these weathering profiles. Where partially or noneroded, these weathering profiles comprise: (1) a capacitive but generally low-permeability unconsolidated layer (the saprolite), located immediately above (2) the permeable stratiform fractured layer (SFL). The development of the SFL’s fracture network is the consequence of the stress induced by the swelling of some minerals, notably biotite. To a much lesser extent, further weathering, and thus hydraulic conductivity, also develops deeper below the SFL, at the periphery of or within preexisting geological discontinuities (joints, dykes, veins, lithological contacts, etc.). The demonstration and recognition of this conceptual model have enabled understanding of the functioning of such aquifers. Moreover, this conceptual model has facilitated a comprehensive corpus of applied methodologies in hydrogeology and geology, which are described in this review paper such as water-well siting, mapping hydrogeological potentialities from local to country scale, quantitative management, hydrodynamical modeling, protection of hard-rock groundwater resources (even in thermal and mineral aquifers), computing the drainage discharge of tunnels, quarrying, etc.
Musical Auditory Alpha Wave Neurofeedback: Validation and Cognitive Perspectives
Authors: Takabatake Kazuhiko , Kunii Naoto , Nakatomi Hirofumi , Shimada Seijiro , Yanai Kei , Takasago Megumi , Saito Nobuhito
Published: April 2021

Neurofeedback through visual, auditory, or tactile sensations improves cognitive functions and alters the activities of daily living. However, some people, such as children and the elderly, have difficulty concentrating on neurofeedback for a long time. Constant stressless neurofeedback for a long time may be achieved with auditory neurofeedback using music. The primary purpose of this study was to clarify whether music-based auditory neurofeedback increases the power of the alpha wave in healthy subjects. During neurofeedback, white noise was superimposed on classical music, with the noise level inversely correlating with normalized alpha wave power. This was a single-blind, randomized control crossover trial in which 10 healthy subjects underwent, in an assigned order, normal and random feedback (NF and RF), either of which was at least 4 weeks long. Cognitive functions were evaluated before, between, and after each neurofeedback period. The secondary purpose was to assess neurofeedback-induced changes in cognitive functions. A crossover analysis showed that normalized alpha-power was significantly higher in NF than in RF; therefore, music-based auditory neurofeedback facilitated alpha wave induction. A composite category-based analysis of cognitive functions revealed greater improvements in short-term memory in subjects whose alpha-power increased in response to NF. The present study employed a long period of auditory alpha neurofeedback and achieved successful alpha wave induction and subsequent improvements in cognitive functions. Although this was a pilot study that validated a music-based alpha neurofeedback system for healthy subjects, the results obtained are encouraging for those with difficulty in concentrating on conventional alpha neurofeedback.

Trial registration: 2018077NI, date of registration: 2018/11/27
Elastic Modulus, Thermal Expansion, and Pyrolysis Shrinkage of Norway Spruce Under High Temperature
Authors: Adibaskoro Tito , Makowska Michalina , Rinta-Paavola Aleksi , Fortino Stefania , Hostikka Simo
Published: April 2021

The orthotropic and temperature-dependent nature of the mechanical properties of wood is well recognized. However, past studies of mechanical properties at elevated temperatures are either limited to temperatures below 200 °C or focus only on the direction parallel to grain. The effect of time-dependent pyrolysis during measurement is often neglected. This paper presents a novel method for determining elastic modulus at high temperatures and thermal expansion coefficient in different orthotropic directions via Dynamic Mechanical-Thermal Analyser (DMTA). The method allows for drying, drying verification, and measurement in one chamber, eliminating the possibility of moisture reabsorption from ambient air. The repeatable measurements can be carried out in temperatures up to 325°C, adequate for observing time-dependent pyrolysis during measurement. Results of the measurements of Norway Spruce provide data of its mechanical response at temperature range previously not explored widely, as well as in the orthotropic direction. Time-dependent behaviour was observed in the thermal expansion and shrinkage experiment, where above 250°C the amount of shrinkage depends on heating rate. At such temperature, elastic moduli measurement also shows time dependence, where longer heating at certain temperature slightly increases the measured elastic modulus. Additionally, bilinear regression of the relationship between elastic moduli and temperature shows quantitatively good fit. Numerical simulation of the DMTA temperature history and wood chemical components mass losses show the onset of shrinkage and onset of hemicellulose mass loss occurring at around the same time, while decomposition of cellulose correlate with the sudden loss of elastic moduli.
Phytoplankton responses to meteorological and hydrological forcing at decadal to seasonal time scales
Authors: Janatian Nasime , Olli Kalle , Nõges Peeter
Published: April 2021

One of the challenges for predicting global change effects on aquatic ecosystems is the vague understanding of the mechanisms of multiple controlling factors affecting phytoplankton dynamics at different time scales. Here we distinguish between hydrometeorological forcing of phytoplankton dynamics at time scales from days to decades based on a 54-year monthly phytoplankton time series from a large shallow Lake Võrtsjärv (58°16′N, 26°02′E) in Estonia, combined with daily data on forcing factors—thermal-, wind-, light- and water-level regimes. By using variance partitioning with linear mixed effect modelling (LME), we found a continuum from the large dominant K-selected filamentous cyanobacteria with strongest decadal scale variation (8–30%) to r-selected phytoflagellates with large stochastic variability (80–96%). External forcing revealed strong seasonal variation (up to 80%), while specifically water level and wind speed had a robust decadal variation (8% and 20%, respectively). The effect of external variables was proportionally manifested in the time scales of phytoplankton variation. Temperature, with a clear seasonal variation, had no impact on the dominant cold tolerant filamentous cyanobacteria in Lake Võrtsjärv. We found the LME as a reliable method for resolving the temporal cross-scale problem. It yielded quantitative results that matched our intuitive understanding of the dynamics of different variables.
An Ethnological Analogy and Biogenetic Model for Interpretation of Religion and Ritual in the Past
Authors: Winkelman Michael James
Published: April 2021

This paper provides a method- and theory-focused assessment of religious behavior based on cross-cultural research that provides an empirically derived model as a basis for making inferences about ritual practices in the past through an ethnological analogy. A review of previous research provides an etic typology of religious practitioners and identifies their characteristics, selection-function features, the societal configurations of practitioners, and the social complexity features of the societies where they are found. New analyses reported here identify social predictors of the individual practitioner types in their relationships to subsistence and sociopolitical conditions (foraging, intensive agriculture, political integration, warfare, and community integration). These relations reveal the factors contributing to social evolution through roles of religious organization in the operation of cultural institutions. The discussion expands on the previous findings identifying fundamental forms of religious life in the relations of the selection processes for religious practitioner positions to their principal professional functions. These relationships reveal three biogenetic structures of religious life involving (1) alterations of consciousness used in healing rituals, manifested in a cultural universal of shamanistic healers; (2) kin inheritance of leadership roles providing a hierarchical political organization of agricultural societies, manifested in priests who carry out collective rituals for agricultural abundance and propitiation of common deities; and (3) attribution of evil activities, manifested in witches who are persecuted and killed in subordinated groups of societies with political hierarchies and warfare. These systematic cross-cultural patterns of types of ritualists and their activities provide a basis for inferring biogenetic bases of religion and models for interpreting the activities, organization, and beliefs regarding religious activities of past societies. Cases are analyzed to illustrate the utility of the models presented.
Poly-Sinc Solution of Stochastic Elliptic Differential Equations
Authors: Youssef Maha , Pulch Roland
Published: April 2021

In this paper, we introduce a numerical solution of a stochastic partial differential equation (SPDE) of elliptic type using polynomial chaos along side with polynomial approximation at Sinc points. These Sinc points are defined by a conformal map and when mixed with the polynomial interpolation, it yields an accurate approximation. The first step to solve SPDE is to use stochastic Galerkin method in conjunction with polynomial chaos, which implies a system of deterministic partial differential equations to be solved. The main difficulty is the higher dimensionality of the resulting system of partial differential equations. The idea here is to solve this system using a small number of collocation points in space. This collocation technique is called Poly-Sinc and is used for the first time to solve high-dimensional systems of partial differential equations. Two examples are presented, mainly using Legendre polynomials for stochastic variables. These examples illustrate that we require to sample at few points to get a representation of a model that is sufficiently accurate.
Homogenization of Coupled Fast-Slow Systems via Intermediate Stochastic Regularization
Authors: Engel Maximilian , Gkogkas Marios Antonios , Kuehn Christian
Published: April 2021

In this paper we study coupled fast-slow ordinary differential equations (ODEs) with small time scale separation parameter$$\varepsilon $$εsuch that, for every fixed value of the slow variable, the fast dynamics are sufficiently chaotic with ergodic invariant measure. Convergence of the slow process to the solution of a homogenized stochastic differential equation (SDE) in the limit$$\varepsilon $$εto zero, with explicit formulas for drift and diffusion coefficients, has so far only been obtained for the case that the fast dynamics evolve independently. In this paper we give sufficient conditions for the convergence of the first moments of the slow variable in the coupled case. Our proof is based upon a new method of stochastic regularization and functional-analytical techniques combined via a double limit procedure involving a zero-noise limit as well as considering$$\varepsilon $$εto zero. We also give exact formulas for the drift and diffusion coefficients for the limiting SDE. As a main application of our theory, we studyweakly-coupledsystems, where the coupling only occurs in lower time scales.
Enhancing the Capacity of Local Health Departments to Address Birth Equity: The Institute for Equity in Birth Outcomes
Authors: Collie-Akers Vicki , Landry Sarah , Ehule N. Jessica , Pecha Denise , Beltran M. Monica , Gilbert Carol , Abresch Chad
Published: April 2021

Introduction

Significant and persistent racial and ethnic disparities exist related to infant mortality and other birth outcomes. Few models exist that aim to prepare organizations to implement essential features, such as community engagement or intervening on social determinants of health.

Methods

Between 2013 and 2015, teams from seven local health departments participated in the Institute for Equity in Birth Outcomes (EI) with the goals of building capacity and implementing changes to address equity in birth outcomes. Four of the teams enrolled in the first cohort (2013–2015), and three enrolled in cohort two (2014–2015). To examine the EI effort and its impact on capacity and implementation of changes, two types of assessments were completed. Capacities of the teams in specific key areas were assessed using “Best Change Process” instruments at the completion of participation in the EI. Teams also documented on an ongoing basis implementation of interventions. The data were analyzed using descriptive statistics and Pearson Correlation tests.

Results

Best Change Process capacity scores were higher in the first cohort than in the second and were highly correlated with implementation of changes (Pearson’s Correlation = 0.838, p = 0.037). Collectively, the teams implemented about 32 new programs, policies, practices, and systems changes aimed at addressing equity in birth outcomes. Most interventions were based on scientific recommendations and local epidemiologic data.

Discussion

The results of the study suggest the EI is a promising approach that may result in strong capacity and ability to implement interventions aimed at addressing equity in birth outcomes.
New insights on homogenization for hexagonal-shaped composites as Cosserat continua
Authors: Colatosti Marco , Fantuzzi Nicholas , Trovalusci Patrizia , Masiani Renato
Published: April 2021

In this work, particle composite materials with different kind of microstructures are analyzed. Such materials are described as made of rigid particles and elastic interfaces. Rigid particles of arbitrary hexagonal shape are considered and their geometry is described by a limited set of parameters. Three different textures are analyzed and static analyses are performed for a comparison among the solutions of discrete, micropolar (Cosserat) and classical models. In particular, the displacements of the discrete model are compared to the displacement fields of equivalent micropolar and classical continua realized through a homogenization technique, starting from the representative elementary volume detected with a numeric approach. The performed analyses show the effectiveness of adopting the micropolar continuum theory for describing such materials.
The distinct existences argument revisited
Authors: Barz Wolfgang
Published: April 2021

The aim of this paper is to take a fresh look at a discussion about the distinct existences argument that took place between David Armstrong and Frank Jackson more than 50 years ago. I will try to show that Armstrong’s argument can be successfully defended against Jackson’s objections (albeit at the price of certain concessions concerning Armstrong’s view on the meaning of psychological terms as well as his conception of universals). Focusing on two counterexamples that Jackson put forward against Hume’s principle (which is central to Armstrong’s argument), I will argue that they are either compatible with Hume’s principle, or imply a false claim. I will also look at several other considerations that go against Hume’s principle, such as, for example, Kripke’s origin essentialism and counterexamples from aposteriori necessity.
Chemical shift assignments of the N-terminal domain of PSD95 (PSD95-NT)
Authors: Zhang Yonghong , Hell Johannes W. , Ames James B.
Published: April 2021

Postsynaptic density protein-95 (PSD95) contributes to the postsynaptic architecture of neuronal synapses and plays an important role in controlling synaptic plasticity. The N-terminal domain of PSD95 (residues 1–71, called PSD95-NT) interacts with target proteins (calmodulin, α-actinin-1 and CDKL5), which regulate the Ca2+-dependent degradation of glutamate receptors. We report complete backbone NMR chemical shift assignments of PSD95-NT (BMRB No. 50752).
A comparative analysis of hazard-prone housing acquisition programs in US and New Zealand communities
Authors: Smith Gavin , Saunders Wendy , Vila Olivia , Gyawali Samata , Bhattarai Samiksha , Lawdley Eliza
Published: April 2021

This article describes the preliminary results of an international comparative assessment of hazard-prone housing acquisition programs (buyouts) undertaken in six US and New Zealand communities. Semi-structured interviews were conducted with government officials and consultants tasked with administering buyout programs following flood, debris flow, and earthquake-based disasters. Key issues analyzed include local capacity, public participation, planning and design, program complexity, funding and financial management, and lesson drawing. The findings are timely given the rise in disaster-related losses, buyouts are increasingly cited as a strategy to reduce natural hazard risk and advance climate change adaptation, and national buyout programs are evolving in both countries to tackle the challenges associated with this complex process.
Relationships between medical students’ co-regulatory network characteristics and self-regulated learning: a social network study
Authors: Bransen Derk , Govaerts Marjan J. B. , Sluijsmans Dominique M. A. , Donkers Jeroen , Van den Bossche Piet G. C. , Driessen Erik W.
Published: April 2021

Introduction Recent conceptualizations of self-regulated learning acknowledge the importance of co-regulation, i.e., students’ interactions with others in their networks to support self-regulation. Using a social network approach, the aim of this study is to explore relationships between characteristics of medical students’ co-regulatory networks, perceived learning opportunities, and self-regulated learning.

Methods The authors surveyed 403 undergraduate medical students during their clinical clerkships (response rate 65.5%). Using multiple regression analysis, structural equation modelling techniques, and analysis of variance, the authors explored relationships between co-regulatory network characteristics (network size, network diversity, and interaction frequency), students’ perceptions of learning opportunities in the workplace setting, and self-reported self-regulated learning.

Results Across all clerkships, data showed positive relationships between tie strength and self-regulated learning (β = 0.095, p < 0.05) and between network size and tie strength (β = 0.530, p < 0.001), and a negative relationship between network diversity and tie strength (β = −0.474, p < 0.001). Students’ perceptions of learning opportunities showed positive relationships with both self-regulated learning (β = 0.295, p < 0.001) and co-regulatory network size (β = 0.134, p < 0.01). Characteristics of clerkship contexts influenced both co-regulatory network characteristics (size and tie strength) and relationships between network characteristics, self-regulated learning, and students’ perceptions of learning opportunities.

Discussion The present study reinforces the importance of co-regulatory networks for medical students’ self-regulated learning during clinical clerkships. Findings imply that supporting development of strong networks aimed at frequent co-regulatory interactions may enhance medical students’ self-regulated learning in challenging clinical learning environments.
Optimizing the hybridization chain reaction-fluorescence in situ hybridization (HCR-FISH) protocol for detection of microbes in sediments
Authors: Jia Zeyu , Dong Yijing , Xu Heng , Wang Fengping
Published: April 2021

Fluorescence in situ hybridization (FISH) is a canonical tool commonly used in environmental microbiology research to visualize targeted cells. However, the problems of low signal intensity and false-positive signals impede its widespread application. Alternatively, the signal intensity can be amplified by incorporating Hybridization Chain Reaction (HCR) with FISH, while the specificity can be improved through protocol modification and proper counterstaining. Here we optimized the HCR-FISH protocol for studying microbes in environmental samples, particularly marine sediments. Firstly, five sets of HCR initiator/amplifier pairs were tested on the laboratory-cultured bacterium Escherichia coli and the archaeon Methanococcoides methylutens, and two sets displayed high hybridization efficiency and specificity. Secondly, we tried to find the best combination of sample pretreatment methods and HCR-FISH protocol for environmental sample analysis with the aim of producing less false positive signals. Various detachment methods, extraction methods and formulas of hybridization buffer were tested using sediment samples. Thirdly, an image processing method was developed to enhance the DAPI signal of microbial cells against that of abiotic particles, providing a reliable reference for FISH imaging. In summary, our optimized HCR-FISH protocol showed promise to serve as an addendum to traditional FISH for research on environmental microbes.
Evidence Review for the American College of Surgeons Quality Verification Part II: Processes for Reliable Quality Improvement
Authors: Fischer Chelsea P. , Hu Lina Q. , Wescott Annie B. , Maggard-Gibbons Melinda , Hoyt David B. , Ko Clifford Y.
Published: April 2021

After decades of experience supporting surgical quality and safety by the American College of Surgeons, the American College of Surgeons Quality Verification Program was developed to help hospitals improve surgical quality, safety, and reliability. This review is the second of a 3-part review aiming to synthesize the evidence supporting the main principles of the American College of Surgeons Quality Verification Program. Evidence was systematically reviewed for 5 principles: case review, peer review, credentialing and privileging, data for surveillance, and continuous quality improvement using data. MEDLINE was searched for articles published from inception to January 2019 and 2 reviewers independently screened studies for inclusion in a hierarchical fashion, extracted data, and summarized results in a narrative fashion. A total of 9,098 studies across the 5 principles were identified. After exclusion criteria, a total of 184 studies in systematic reviews and primary studies were included for assessment. The identified literature supports the importance of standardized processes and systems to identify problems and improve quality of care.