bluuebunny/crossref_metadata_2025 huggingface dataset:
Typing of normal and variant red cells with ABO, Rh, and Kell typing reagents using a gel typing system
Authors: Tills D. , Bushrod J. , Ward D.J. , Josef D.
Published: June 2021

In 1989 Lapierre et al. described a novel method of detecting agglutination reactions by the use of a Sephadex (DiaMed ID Typing System) gel held in a microtube. This report examines the use of gels containing ABO, Rh, and Kell system specific antibodies. The anti-A and -B were monoclonal reagents; anti-A,B, and those for the Rh and Kell systems were polyclonal. Five hundred and fifty-one tests performed for the ABO system detected all but the most weakly reacting variants, a detection rate superior to most commercially available reagents. Five hundred and thirty samples were typed for Rh antigens. One hundred and twenty-seven of these were of various D category III through VII types (Dcats) and 154 were DUs. The gel system detected all but seven DVI variants and seven DUs. The seven DVI variants, from individuals with no anti-D in their sera, gave reactions identical to the seven DUs when tested against a panel of over 50 monoclonal IgG and IgM anti-Ds. The 554 samples tested for the K1 antigen gave correct results.
Immunohematology
1991;7:94–97.
Red cell antibody identification by solid phase red cell adherence utilizing dried RBC monolayers
Authors: Stone D.L. , Eatz R.A. , Rolih S.D. , Farlow S.J. , Hudson G.S. , Sinor L.T.
Published: June 2021

Recent technological advances in the immobilization and drying of red cell monolayers for use in solid phase red cell adherence (SPRCA) assays have resulted in the development of reagent red cells for antibody screening and identification that are stable at room temperature. Panels consisting of twelve different RBC samples dried onto individual microplate wells were evaluated with 176 samples whose antibody specificities had previously been determined by conventional hemagglutination techniques. Identification tests performed with dried SPRCA panels proved to be more sensitive and less time consuming than hemagglutination tests. The red cell antigens of dried membranes were shown to be stable and reactive following storage for 120 days at room temperature.
Du phenotyping by the rosette technique when the direct antiglobulin test is positive
Authors: Werch J. , Todd C. , Moulds M.
Published: June 2021

The rosette technique provides a simple rapid and accurate procedure for Du phenotyping of red blood cells (RBCs) with a positive direct antiglobulin test (DAT) due to antibodies other than those of the Rh system. We used Sebring and Polesky’s rosette technique to test RBCs with positive DATs. Characteristic microscopic agglutination was observed for the Du phenotype which was different from the mixed-field agglutination seen as positive rosettes in feto-maternal hemorrhage (FMH). The microscopic “starry-sky” pattern typical for FMH-positive rosettes is easily differentiated from the uniform agglutination produced by the Du phenotype. The rosette technique was performed on 202 Rh-negative cord RBCs out of 4815 cord cells with a positive DAT. Parallel testing for Du by the chloroquine elution and antihuman globulin (AHG) test was done on 67 of the 202 cases. Four Du RBCs that were identified by the rosette technique were confirmed by the chloroquine Du technique. The rosette technique proved to be time saving and as sensitive as the routinely performed elution technique for removal of antibodies followed by the AUG Du test.
A case report: clinically benign anti-Csa
Authors: Sererat T. , Alexander J. , Beatty J.
Published: June 2021

Previous reports on the clinical significance of anti-Csa(Cost-Stirling) have presented conflicting data. We report our findings, over an 8-month period, of a patient whose serum contained anti-Csa and anti-Fya. Nineteen donor units of ABO and Rh-matched, Fya-negative red cells, which were crossmatch incompatible, were transfused with no clinical, serological, or biochemical evidence of a hemolytic transfusion reaction.
Antibody detection errors due to acidic or unbuffered saline
Authors: Rolih S. , Thomas R. , Fisher F. , Talbot J.
Published: June 2021

Isotonic saline solutions, buffered with potassium phosphate or sodium phosphate salts, were evaluated in parallel with unbuffered saline to determine if they improved antibody detection by solid phase red cell adherence or hemagglutination methods. Saline buffered to a pH of 7.0 to 7.5, when used to suspend red cells or to wash sensitized red cells in preparation for the antiglobulin test, produced the best positive solid phase and hemagglutination results. The pH range of commercially prepared blood bank saline (unbuffered) was found to be 5.8 to 6.8, far lower than the desired pH for optimum antibody detection. In the case of solid phase assays employing intact, immobilized reagent red cells, saline with a pH of 7.0 to 7.5 also eliminated falsely positive results due to the dissociation of red cell monolayers from the solid support surface that occurred in the presence of unbuffered or acidic saline. These findings indicate that unbuffered isotonic saline should not be used in solid phase- or hemagglutination-based antibody detection tests. It is recommended that phosphate-buffered saline at a pH of 7.0 to 7.5 be employed.
Immunohematology
1993;9:15.
Six monoclonal antibodies to the CD59 antigen
Authors: Bryant J.A. , Fletcher A. , Yuan F.F.
Published: June 2021

CD59 defines an N-glycosylated glycoprotein expressed on various hemopoietic cells. It is anchored to the cell membrane by a glycosylphosphatidylinositol linkage and restricts the action of homologous complement. Monoclonal antibodies 2/24, 1B2, Fib75.1, BRIC 229, MEM-43, and YTH 53.1 were compared by immunoblotting against normal erythrocyte ghosts. All six stained a diffuse band of 17–25 kDa, but BRIC 229 also detected bands at 35 and 80 kDa. 2/24 reacts with all red blood cells (RBCs) tested, including Rhnull; Oh; ii; KO; FY:−1,−2,−3 JK:−1,−2,−3; S-S-U−; p; CO:−1,−2; Yt(a–);Jr(a–); Vel–; At(a–); Cr(a–); GE:−2−3; Wr(a+b−); MkMk; Jo(a–); and Lan–. 2-aminoethylisothiouronium bromide treatment of erythrocytes destroyed blotting and serologic reactivity of all six antibodies. Pronase treatment reduced serologic reactivity and blotting ability of all antibodies except BRIC 229. Reactivity of all six antibodies was reduced with RBCs from paroxysmal nocturnal hemoglobinuria patients. Flow cytometric analysis was used to demonstrate that 1B2, Fib75.1, BRIC 229, YTH 53.1, and MEM-43 competitively inhibited the binding of 2/24 to RBCs, thus demonstrating that all six antibodies detect epitopes on the same molecule.
Immunohematology
1993;9:68.
Case report: a time study of management of a chronically transfused patient with multiple antibodies
Authors: Kitchen K. , Corgan M. , Hillard B.
Published: June 2021

This case report describes laboratory management of a chronically transfused sickle cell anemia patient with multiple antibodies and the time involved in providing compatible red cells for transfusion. Time was evaluated using the laboratory workload recording method of the College of American Pathologists. Red cell units were sent to the hospital within 24 to 48 hours from receipt of a referral sample, despite a workload recording time in excess of 15 hours for a typical sample.
Immunohematology
1993;9:81.
A Polynesian family showing co-dominant inheritance of normal glycophorin C and the Gerbich variant form of glycophorin C
Authors: Reid M.E. , Poole J. , Liew Y.W. , Pinder L.
Published: June 2021

Two individuals with the rare Ge:−2,−3,4 phenotype (Gerbich type of Gerbich negative) were identified in a family of Polynesian descent who reside in the Cook Islands. In initial serologic tests, all other family members typed as Ge-positive, and heterozygous individuals could not be identified. Further studies on blood samples from seven members of this Polynesian family by immunoblotting and hemagglutination tests on trypsin-treated red blood cells showed that normal glycophorin C and the prodUR of the Gerbich allele were inherited in an autosomal dominant manner.
Immunohematology
1992;8:29–32.
Cytomegalovirus antibody screening on the Olympus PK7100
Authors: Mohabir L.A.
Published: June 2021

The Olympus PK™ CMV system (OHA) for the detection of antibodies to cytomegalovirus (CMV) was evaluated for use on the Olympus PK7100 automated pretransfusion blood testing instrument. Indeterminate reactions were obtained with 18 (1.2%) of the 1,495 samples originally tested, of which 9, 6, and 3 were OHA positive, indeterminate, and negative, respectively, on retest. The OHA was found to have a concordance of 99.7 percent when tested in parallel with the CMV Scan latex agglutination test (LAT). There were four discrepant results in the 1,495 donor plasmas tested by the two methods. Two of the three samples that were positive by the LAT and negative by the OHA test were also negative with the IMx enzyme-linked immunosorbent assay (ELISA) and complement fixation test (CFT). The OHA failed to detect antibodies to CMV in a sample that was positive by the IMx ELISA, CFT, and LAT. The IMx ELISA, which was regarded as the arbiter of true positivity, yielded a sensitivity and specificity of 99.9 percent and 100 percent respectively, for the Olympus PK™ CMV system. Forty percent of 1,807 random blood donors in this region had antibodies to CMV. CMV testing can be performed simultaneously with blood grouping and red cell antibody screening on the Olympus PK7100. Immunohematology 1992;8:41–43.
CYSTIC LYMPHANGIOMA A CASE REPORT
Authors:   Department of General Surgery, University Hospital Center Mohamed VI, Marrakech, Morroco., E.C Etoka , Bicane MA ,   Department of General Surgery, University Hospital Center Mohamed VI, Marrakech, Morroco., K Rabbani ,   Department of General Surgery, University Hospital Center Mohamed VI, Marrakech, Morroco., H Lammat ,   Department of General Surgery, University Hospital Center Mohamed VI, Marrakech, Morroco., A Louzi ,   Department of General Surgery, University Hospital Center Mohamed VI, Marrakech, Morroco.
Published: June 2021

Cystic lymphangioma of the pancreas is a rare benign vascular tumor. Its histogenesis is still hypothetical and its preoperative diagnosis difficult to establish. We report a case in a 26-year-old boy who presented with abdominal pain with the notion of a constipation-type transit disorder. Radiological investigations showed an intraperitoneal mesenteric cystic tumor. A complete resection of the mass was performed. Pathological examination of the operative specimen confirmed the presence of cystic formations, the wall of no need keep it.to the end which was lined by a squamous, endothelial epithelium with a fibrous wall dotted with a few lymphoid clusters in favor of cystic lymphangioma.
REFLEXIONES EN TORNO A LA GOBERNANZA UNIVERSITARIA: UNA MIRADA DESDE PERU
Authors: Enrique Reyes Acevedo Jesus , Angelica Lavanda Reyes Flor , Felicita Martinez Garcia Rosa
Published: June 2021

In Latin America, since the first decades of the last century, universities have been agents of change based on student mobilizations, both to reform them and to contribute to the development of society based on demands in favor of freedom, democracy and civil rights. The development of the State is largely explained by professional training universities. The university, without any doubt, plays a preponderant role in the process of understanding itself, in the development of organizations in general and in the environment in which it is inserted. Many are the tasks attributed to him and there are not a few representatives who dare to assign him the role of brain of society. In order for an entity of such nature to be able to adequately fulfill its mission, it must necessarily be well managed, technically projected and appropriately led. Unfortunately, this is not achieved only with good wills and intentions since the fundamental component lies in the ability and knowledge the above characteristics, are mere ingredients or could be in the category of sine qua non.
PERITONITE PRIMITIVE ET GROSSESSE A PROPOS DUN CAS CHU-MOHAMED VI MARRAKECH, UNIVERSITE CADI AYYAD SERVICE CHIRURGIE VISCERALE
Authors: E.C Etoka , H. Tamour , K. Rabbani , Y. Ibenloualid , H. Lammat , A. Louzi
Published: June 2021

Primaryperitonitisis rare in patients withoutriskfactors. Theysimulatesecondaryperitonitis. This iswhytheirdiagnosiscanonlybeintraoperative. We report a case of primaryperitonitis in pregnantwomen in order to discusstheir diagnostic and therapeutic aspects. Keywords:Diagnosis, primaryperitonitis, treatment.
COVID-19 AND ATTITUDES OF GROUND-LEVEL PUBLIC HEALTH STAFF IN SRI LANKA
Authors:   MBBS, MSc Community Medicine, MSc Medical Administration, Post Graduate Institute of Medicine, University of Colombo, Sri Lanka, pharshani@gmail.com, ORCiD ID: 0000-0003-0878-6063., Harshani Warnakulasooriya Pavithra , Mahendra Arnold S. ,   MBBS, MD Community Medicine, Deputy Director-General in public health Services (1), Ministry of Health, Sri Lanka.
Published: June 2021

Introduction: Health care workers (HCW) face considerable mental and physical stress caring for patients with Covid-19. Their attitudes towards COVID-19 are important both in the prevention as well treatment of the disease. Aims: To assess the attitudes toward coronavirus disease-2019 (COVID-19) among community healthcare workers at Regional Director of Health Services area Galle district, Sri Lanka. Settings and Design: A cross-sectional study was carried out between August 2020 and January 2021 at the Regional Director of Health Services area Galle district, Sri Lanka. Methods and Material: All community healthcare workers who were directly involved in COVID-19 in Galle district, Sri Lanka were recruited for the study, and the data was collected through a self-administered questionnaire. Descriptive analysis was done to describe the demographic factors and attitudes Chi-square test was used to assess the relationship between the level of attitude and demographic factors. Statistical analysis used: Chi-square test. Results: Of the community health workers 71%(n=84) had a positive attitude indicating a good attitude regarding the COVID-19 prevention strategies. Nearly 91%(n=107) of the population agreed to vaccination against COVID-19. There was no statistically significant association between attitude on COVID-19 with sex, age, marital status, educational level, service period, and category of occupation. Conclusions: A majority of healthcare workers had positive attitudes toward COVID-19. Additional awareness and continuous knowledge updates are required for healthcare workers to sustain positive attitudes during the pandemic.
RETENTION IN MAXILLOFACIAL PROSTHESIS: A LITERATURE REVIEW
Authors:   PG Resident ,Department Of Prosthodontics and Crown & Bridge, Pushpagiri College Of Dental Sciences, Thiruvalla, Pattanamthitta , Kerala, India., YS Saranya , Joseph Suja ,   Professor , Department Of Prosthodontics and Crown & Bridge, Pushpagiri College Of Dental Sciences, Thiruvalla, Pattanamthitta , Kerala, India., Mathew T Aby ,   Professor and Head , Department Of Prosthodontics and Crown & Bridge, Pushpagiri College Of Dental Sciences, Thiruvalla, Pattanamthitta , Kerala, India., Susan Thomas Annie ,   Professor , Department Of Prosthodontics and Crown & Bridge, Pushpagiri College Of Dental Sciences, Thiruvalla, Pattanamthitta , Kerala, India., Soman Aswati ,   PG Resident ,Department Of Prosthodontics and Crown & Bridge, Pushpagiri College Of Dental Sciences, Thiruvalla, Pattanamthitta , Kerala, India., Harshakumar Minnu ,   PG Resident ,Department Of Prosthodontics and Crown & Bridge, Pushpagiri College Of Dental Sciences, Thiruvalla, Pattanamthitta , Kerala, India.
Published: June 2021

Defects in the maxillofacial region can be congenital or acquired, and may negatively affect their physical and psychological health, hence such defects require rehabilitation to improve the quality of life. Maxillofacial prosthesis helps in substituting these missing body parts. The mode of retention is always challenging. Apart from the various modes of retention available, a thorough treatment planning can give a better quality of maxillofacial prostheses. The type of retentive to be given depends on several factors such as the shape and size of the defect, the systemic conditions and the age of the patient. Using ideal retentive aids along with the aesthetic, functional and economic factors helps in achieving successful outcomes.
PATTERNS OF SUSCEPTIBILITY TESTING OF ANTITUBERCULOSIS DRUGS AMONG PATIENTS ATTENDING TUBERCLOSIS CLINIC IN KAKAMEGA TEACHING AND REFERALL HOPITAL KENYA
Authors:   School of Nursing And Midwifery, Masinde Muliro University of Science and Technology, Kenya., Erick K Kibai , Victor Dinda ,   School of Public Health Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, Kenya.
Published: June 2021

Drug Resistance Tuberculosis (DR TB) is a form of tuberculosis infection that is resistance to treatment with Rifampicin and Isoniazid with or without resistance to one or more other drugs used in the first line treatment of tuberculosis (Mitchison, 2012). Kenya is ranked 13th among the 22 high TB burden countries worldwide (WHO, 2013). MDR TB is a global health security risk and carries grave consequences for those affected (WHO, 2014). Its development is associated with high mortality rates and low levels of productivity among workers due to the high cost of care which imposes a heavy economic burden on the nation (Eduardo, 2011). DR TB therefore poses a major challenge to tuberculosis care and control (Ellen & McNerney, 2008). Limited literature talks about the exact prevalence of resistance to anti-tuberculosis drugs in populations with high rates of tuberculosis (WHO, 2015). In addition, only a few isolated cases of multiple drug resistant tuberculosis have been reported in Kenya (Ogaroet.al., 2012). This study aimed at determining the burden of pattern of Drug Restance TB via determination of the prevalence of TB and the gene resistance patterns to the two most commonly used anti- TB drugs Rifampicin and Isoniazid. A cross-sectional study was conducted among new and re-treatment cases of tuberculosis referral patients in Kakamega county teaching and referral hospital between June and August 2018. A total of 138 patients were enrolled for the study and the health facility TB register questionnaire was used to obtain data on demographic factors of the patients. Data generated was analyzed using the statistical package for social sciences (SPSS) version 22.0 to find case summaries. Descriptive statistical tests were performed on the data including means, modes, percentages, standard deviations and percentiles. Data was then presented in pie-charts, bar graphs and tables. Out of the 138 cases seventy (50.7%) were male and sixty-eight (49.3%) female. All the study cases were new. Twenty-eight (20.3%) of the isolates became positive for MTB. Of these, eight (5.7%) isolates showed resistance to either of the two first line drugs tested while twenty (14.5%) were fully susceptible. None of the isolates tested became positive for Drug resistant tuberculosis. Notably most of the resistant cases were found to be among HIV positive patients (4.3%) with (1.4%) of the cases being from HIV negative patients. This study revealed high levels of drug resistance among new cases of untreated patients. This implies ongoing transmission of drug resistant strains in the community.
IMMORALLY AND UNETHICALLY FACILITATING THE DIVINE: MEDICAL ASSISTED SUICIDE, DR. DEATH, AND PLAYING GOD
Authors:   Newberry College., S. Fowler , Ph.D. David
Published: June 2021

This article is amedicalethics opinion piece regarding the historical and questionable exercise of medical assisted suicide. As this is a practice involving significant debate over many years, opinions of those who follow a divine-led path should be voiced with cognition. Thoughts are expressed and specifiedconcerning the ethicality and morality of humanly facilitating Gods plans of life expectancy for individuals. It is not proper, nor is it inspired by our Creator to define life cycles based on our own wishes or perceived entitlements.
ESSAI DE DETERMINATION DUN TAUX OPTIMAL DINFLATION AU MAROC
Authors: Hakik Idriss
Published: June 2021

Cette etude analyse empiriquement le lien entre linflation et la croissance economique au Maroc. Un modÃƒÂ¨le liant la croissance et linflation a ete estime sur les donnees annuelles allant de 2000 a 2018. Un lien negatif a ete decele entre ces deux variables, sous le contrÃƒÂ´le de deux autres variables mesurant un facteur de production et un agregat de politique budgetaire. Il apparait ainsi que linflation doit etre maintenue a un niveau bas pour booster la croissance. Tout le problÃƒÂ¨me est de savoir a quel niveau bas doit se situer exactement linflation. Letude a estime le taux dinflation optimal en utilisant un modÃƒÂ¨le a effets de seuil sur les memes donnees et avec des hypothÃƒÂ¨ses de 15 seuils dinflation croissants. Les resultats ont identifie un taux dinflation de 4,5% comme etant optimal ou celui qui minimise la somme des carres de residus de lequation de regression correspondante. Dans le contexte marocain, ce taux peut-etre ainsi considere comme le seuil au dela duquel, linflation inhibe fortement la croissance. A linverse, tout autre niveau dinflation en deÃƒÂ§a et proche de 4,5% ne freine pas trop la croissance, sil ne la booste pas. Les resultats de letude permettent ainsi de concilier les tenants dune inflation courte, et ceux dune inflation moderee. Cependant, la proposition centrale de letude reside dans la simplicite de la methode utilisee pour estimer le taux dinflation optimal. Une simplicite qui permet un ciblage aise de linflation et des echanges transparents pour un dialogue fructueux entre les acteurs de la politique economique : techniciens et decideurs.
EFFECT OF ORGANISATIONAL CONTEXTUAL FEATURES ON SERVICE QUALITY OF SELECTED INDIGENOUS AIRLINE COMPANIES IN NIGERIA
Authors:   Department of Business Administration and Marketing, School of Management Sciences, Babcock University, Ilishan-Remo, Nigeria., J.J. Akinshipe , A.D. Adefulu ,   Department of Business Administration and Marketing, School of Management Sciences, Babcock University, Ilishan-Remo, Nigeria., H.B Akinlabi ,   Department of Business Administration and Marketing, School of Management Sciences, Babcock University, Ilishan-Remo, Nigeria.
Published: June 2021

Service quality provides an incentive for customers to come back to make repeat demand. Studies have shown that Nigeria aviation industry has failed to put into proper perspective the service quality specific dimensions of reliability, responsiveness, tangibility, assurance, and empathy in its service delivery. The study therefore examined the effect of organisational contextual features on the service quality of Airline companies in Nigeria. Cross sectional survey research design was adopted and the population was 2881 regular employees of Arik airline, Aero Contractors airline, Med View airline and Air Peace airline. The sample was 441 determined using Krejcie and Morgan (1970) formulain addition to an attrition rate of 30%. The study used the proportionate sampling technique. Data were collected using an adapted, structured, and validated questionnaire. The Cronbachs Alpha coefficients for the constructs ranged from 0.798 to 0.853. The response rate was 78.8%. Data collected were analyzed using descriptive and inferential (multiple linear regression) statistics. The finding revealed that organisational contextual features through organisational culture and organisational structure have statistically significant effect on service quality of the selected indigenous airline companies in Nigeria. The study recommended that Indigenous airline companies in Nigeria should ensure establishment of organic structure and sustenance of people oriented corporate culture that promote customer satisfaction, customer loyalty and customer delight through service quality that guarantee patronage from air travelers in Nigeria and overseas.
INTERACTION OF OBJECT, SUBJECT AND SYNERGETIC CATEGORIES IN SCIENTIFIC WORK
Authors:   Candidate of Philosophy Andijan Machine Building Institute Professor of the Humanities Department., Nazarov M.
Published: June 2021

This article is about one of the most fundamental categories of philosophy, the object and the subject, and focuses on its place and role in scientific research. The objective of the research activity is the object in the broadest sense of reality. The researcher acts as a subject, whether it is an individual or a specific community (creative team). Synergetics has gained the status of a philosophical category as a branch of science and is important in the study of significant changes in the universe.
BACTERIOLOGICAL PROFILE OF INFECTIONS IN BURNS UNIT - PLASTIC AND RECONSTRUCTIVE SURGERY DEPARTMENT - MOHAMMED VI CHU MARRAKECH
Authors:   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., Mohamed Elmehdi Sahibi , Imane Yafi ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., El Mehdi Mahrouch ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., Mehdi Elgueouatri ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., Ismail Zineddine ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., Benlaasel Oumnia Ait ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., Driss Elamrani Moulay ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco., Banchamkha Yassine ,   Department of Plastic and Reconstructive Surgery in CHU Mohamed VI, Marrakech, Morocco.
Published: June 2021

The nosocomial bacterial infection being one of the main causes of morbidity and mortality in burn patients, our work aimed on describing the nosocomial bacterial infections in order to establish the bacteriological profile to adapt the antibiotic therapy to our service. This is a retrospective study of 502 bacteriological samples taken from 65 patients hospitalized in the Resuscitation of burns of the plastic surgery department of the CHU Mohamed VI of Marrakech, over a period of 3 years, from January 1, 2016 to December 31, 2018. For this which is characteristic of bacterial infections, the infected sites were mainly the skin (50.1%) and blood (37.7%). The main germs were: Coagulase Negative Staphylococcus (32.1%), AcinetobacterBamannii (13.8%) Staphylococcus Aures (8.45%) AND Pseudomonas Aeruginosa (8.2%). Staphylococci were metabolic-resistant in 16.6% of cases Pseudomonas and Acinetobacter were multidrug resistant (60%). Establishing the bacterial ecology of the service, allowed us to set the right rules for prescribing antibiotic therapy, which was a function of the infected site, the type of germ, its sensitivity, the molecule used and the particular pharmacokinetics in the burn patient.
PLASTIC SURGERY & ADVANCED SCALP TUMORS: EPIDEMIOLOGICAL PROFILE AND SURGICAL MANAGEMENT ABOUT 65 CASES
Authors: Mohamed Elmehdi Sahibi , El Mehdi Mahrouch , Imane Yafi , Mehdi Elgueouatri , Ismail Zineddine , Benlaasel Oumnia Ait , Driss Elamrani Moulay , Banchamkha Yassine
Published: June 2021

The scalp is the most frequent site of occurrence of malignant tumors. As an area that is generally neglected by the patient and not closely monitored during physical examinations. Plastic surgery has a double interest in the management of malignant tumors of the scalp: it allows oncologic tumor excision and coverage of defects induced. The present study reports 65 cases of giant malignant tumors of the scalp and who underwent surgical management, from January 2011 to June 2019. It included oncologic resection and repair of the defect. The average age in our series was 69.3 years, with a sex ratio of 5.1. Disease duration before consultation was on average 21 months. The location of the tumor was mostly parietal in 75%. The histological types were found in our series: 36 cases of squamous cell carcinoma, 16 cases of basal cell carcinoma, 6 cases of melanoma, 3 cases of trichilemmal carcinoma, 2 cases of dermatofibrosarcoma protuberans and one case of sarcoma and one case of adenoid cystic carcinoma . To cover the defect we used: skin graft in 44 cases and by local flaps in 21 cases. 42 patients benefited from radiotherapy and the evolution was marked by a reactivation in 3 cases of squamous cell carcinoma. The management of malignant tumors of the scalp is surgical and consists of two components: surgical excision and coverage. This repair is achieved through multiple techniques, facilitated by the vascular richness of this anatomical region.
IMPACT OF COVID 19 ON NIFTY 50 VOLATILITY
Authors: Gupta Aman
Published: June 2021

COVID 19 has severely affected global financial markets and it has long lasting impact on Nifty 50. The increasing daily new and total COVID 19 cases lead to anxiety among investors and there was panic selling because of lockdown and after government incentives and plan to revive the market, Nifty 50 touched itÃ¢Â€Â™s all time high. We can clearly imagine the amount of volatility COVID 19 created in the market. VIX touched all time high of 66.04 from 13.68 points. This research paper aims to study the magnitude of impact of COVID 19 on Nifty 50 volatility using GARCH model.
INTEGRATED MARKETING COMMUNICATION STRATEGY IN THE MIDDLE OF ONLINE MEDIA GLOBALIZATION (CASE STUDY IN KOMPAS NEWSPAPER)
Authors:   Research Scholar, Department of Communication Studies, Indonesian Persada University YAI., Ezer Eben
Published: June 2021

In the middle of the globalization of online media, newspapers as print media are currently experiencing competition in the media industry. Many people who used to use newspapers as the main media in accessing news information have now shifted to online media, resulting in many newspapers in Indonesia that have started to dislike their readers. One of the newspapers in Indonesia is the daily Kompas . To overcome this, an integrated marketing communication strategy effort is needed which must be carried out by the Kompas newspaper marketing in order to exist in the middle of todays online media globalization. online today. This research uses the theory of Elaboration Likelihood theory (ELT) and Integrated Marketing Communication (IMC). In addition, the research uses marketing concepts, strategic concepts, communication strategy concepts, digitization concepts and print media concepts. The approach used in this study is a qualitative approach with descriptive interview methods. This research method is to use a case study approach which intends to describe the results of the research and try to find a comprehensive description of a situation. In addition, data collection techniques in this study were carried out by in-depth interviews and observations. The results of the discussion in this study are that Kompas daily newspaper uses five marketing mix strategies in maintaining its existence in the middle of globalization of online media today. The five strategies are direct marketing, sales promotion, public relations, personal selling and advertising. The conclusion in this study is that the five strategies are running very well in the Kompas daily newspaper so that the Kompas daily newspaper still exists today in the midst of the globalization of online media.
CHARACTER-ORIENTED HUMAN RESOURCES MANAGEMENT OF ISLAMIC BOARDING SCHOOL (PONDOK PESANTREN) IN LAMPUNG PROVINCE, INDONESIA
Authors:   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., Aziz Abdul , Kholid Idham ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., Basyar Syaripudin ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., a Subandi ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., b Koderi ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia.
Published: June 2021

Islamic boarding school (Pondok Pesantren) is the oldest educational institution in Indonesia. It is an authentic Indonesian cultural heritage. The advancement of science and technology has influenced the Islamic boarding schools paradigm. On the other hand, the Islamic boarding school must be consistent in maintaining its cultural characteristics. There are four types of Islamic boarding schools in Lampung Province: pure Salafiyah, Madrasah Diniyah Takmiliyah, formal Diniyah education, and Takhassus. This study aims to determine the character-oriented human resource management of Islamic boarding schools in Lampung Province. This study employed the qualitative approach, which utilized interviews, observations, and documents to collect the data. The findings of this study are 1) the Islamic boarding schools human resource management planning includes needs analysis, recruitment, selection, and placement. 2) the implementation of Islamic boarding schools human resource management includes education through routine recitation, routine coaching, workshops, training, seminars, comparative studies, tawajjuhan thariqoh, night prayer (qiyamul lail), five daily prayers, routine dzikir, and tahsin and tahfidz Al Quran. 2) The human resource management Evaluation of Islamic boarding schools is carried out once a month, every two months, once every three months, at the end of the semester, at the end of the school year, and even at any time. The planning, implementing, and evaluating character excellence are done through 1) moral character, which includes trustworthiness, honesty, responsibility, sincerity, courtesy, qanaah, loyalty, and militancy. 2) Performance characters must include competence, discipline, punctuality, respect for time, collaboration, hard work, and thoroughness.
EVALUATION OF COVID-19 PANDEMIC- RELATED DEPRESSION IN GERIATRIC PATIENTS AT PRH, LONI: A CROSS SECTIONAL STUDY
Authors:   Intern, Community Physiotherapy Department, Dr. A.P.J Abdul Kalam College of Physitherapy, PIMS, Loni, India, Sakshi Deshmukh., Deshmukh Sakshi , Sant Shrikant ,   Associate Professor, Community Department,Dr. A.P.J Abdul Kalam College of Physitherapy PIMS, Loni, India, Dr. Shrikant Sant.
Published: June 2021

Question:Has COVID-19 Pandemic affected the psychological health of the elderly patients at PRH, Loni? Design: Descriptive Participants: 300 Intervention: Non Interventional Outcome measures: Geriatric Depression Scale (GDS- 15) Score Results: The average of males having significant depression determined, using Geriatric Depression Scale (GDS-15) was 3.56 whereas for females, it was 3.48. The difference in scoring depression between males and females was 1% percentage wise. Conclusion: On an average 41.8% of geriatric patients at PRH, Loni suffered from depression according to GDS- 15 score grading, during the time span of 3 months i.e. from January 2021 to March, 2021. Both inpatients as well as outpatients visiting PRH, Loni were included in the study with equal number of participation of males and females. This study concluded that males suffered from depression slightly higher than females. From the three categories of depression, mild depression had the highest rating than moderate and severe types of depression which was higher in females than in males. Broadly speaking, mild depression was the highest amongst older adults aged between 60 to 80, out of which females were moreover affected than males with a difference of 2.1%. Moderate depression amongst males was 4.6% and in females was comparatively higher with the percentage of 5.3%. The gender difference in the scoring was 2.1%. The percentage of Severe depression was 0.6% in males and was nil in females despite having a slightly higher rate of depression, in general at PRH, Loni.
DESIGN OF AN AUTOMATED BOTTLE PACKAGING SYSTEM
Authors:   Mechanical Engineering Department, Sinhgad College of Engineering Pune, India., Baroorkar Abhinav , Dolas Pavan ,   Mechanical Engineering Department, Sinhgad College of Engineering Pune, India., Nagorao Dhule Adarsh ,   Mechanical Engineering Department, Sinhgad College of Engineering Pune, India., Kulkarni Adwait ,   Mechanical Engineering Department, Sinhgad College of Engineering Pune, India.
Published: June 2021

Industry 4.0 is changing the efficiency and output of current industries significantly. It is finding its way in every small application one can think of. Though in some small-scale industries in the developing countries are unable to afford such machines. Taking this into consideration this paper proposes a system to automate the process of packaging bottles by using different sensrs and actuators, which will be affordable to the small industries. Automating this final stage in the production of different bottles, will not only increase the efficiency of the industry but also save a lot of money in the long run.
FROM STATION OF LIFE TO STATION OF DEATH IN THE CHARACTERS OF DANCER AND THE GENTLEMAN OF ONEILLS PLAY THIRST ALONG WITH DIVERSE SYMBOLISM
Authors:   Magadh University, Bodh Gaya (English Department)., Goswami Ramen
Published: June 2021

The Thirst centres on the struggle of three shipwreck victims to survive on a small white raft adrift on a glassy sea. Descending into madness as a result of their thirst, they prey on each other until they sacrifice their humanity to the uncaring, black-stained sea. Despite their common predicament, the three are separated by social, as well as psychological, forces. The Dancer is called young from the stage direction of the play. ONeill described her as figure of pitiful care. The Gentleman has been portrayed by O Neill in The Thirst, as a symbolic agent of the practical civilized world-Virginia Floyd. All through the action of the play he exhibits mostly civilized and dignified behaviour and upholds his morality to the bitter end.- Alfred Routz. While himself suffering, he mostly sympathizes with the unbearable suffering of the delicate young lady that the Dancer is. For, this reason, O Neill presented the European man as the name of Gentleman. Symbolism is indicative of a lot deeper sense in simple and commonplace matter. Conventional well-known materials are used to suggest some deeper sense or truth of life and society through a symbolic treatment. A careful reading of ONeills plays will show that in each play he seeks to communicate his feelings about life. It is invariably true that the natural objects he uses in his plays like the sun, the sky, the sea (p,51)etc. are symbols and images of something. The same thing is true of his stage props and even of the make-ups, costumes, the looks, the important gesture(p,51) and even the vocal nuances of his characters.
Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy
Authors: Aghamiri Shahin , Raee Pourya , Shahmohamadnejad Shiva , Shabani Sasan , Ghorbani Jaber , Sameni Marzieh , Ebrahimi Mohammad Taha
Published: June 2021

The critical problems of conventional prostate cancer therapeutic strategies like nonspecific
toxicity and multi-drug resistance prompted the development and application of countless nanoparticle-
based siRNA therapeutics. Unfortunately, siRNA-based therapeutics suffer from the lack of
safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions,
and limitations concerning designing, manufacturing, clinical translation, and commercialization.
In this review, we provide cutting-edge advances in nanoparticle-mediated siRNA delivery
carriers like polymeric systems, lipid systems, specific systems, and rigid nanoparticles for the treatment
of prostate cancer. Moreover, co-delivery of conventional chemotherapy drugs with siRNA as a
revolutionary robust strategy for prostate cancer combinational therapy is completely covered.
A Mini-Review on the Effectiveness of Peptoids as Therapeutic Interventions against Neurodegenerative Diseases
Authors: Paul Subha Sankar , Biswas Goutam
Published: June 2021

:

Neurodegenerative diseases have emerged as one of the major age-associated diseases in
recent years. Hence, the urge to understand the mechanism and to find targeted therapeutics becomes
inevitable. Peptide-based compounds have emerged as one of the important tools for their
therapy. However, due to a lack of tolerability, specificity, and proteolytic degradation, they have
lost their applicability in the broader sense.

:

Thus, the search for suitable alternatives or peptidomimetics becomes an important criterion for
neurotherapeutics. One of the versatile peptidomimetics is N-substituted glycines or peptoids, which
retain many properties of peptides but successfully evade the drawbacks of peptides. Peptoids are
manifested with greater cellular permeability, less immunogenicity, and their ability to be administered
intra-nasally. These properties enhance their potential as neurotherapeutics with respect to
their peptide counterparts. Recently, peptoids have been explored for neurotherapeutic applications
as aggregation inhibitors, cell signaling pathways modulators, and agents for inhibiting inflammation
via multiple mechanisms. Peptoids, due to their versatility and low production cost, are becoming
popular among peptidomimetics as potential neurotherapeutic agents. In this review, the diverse
applications of peptoids with respect to neurodegenerative disease have been explored.
Targeted Therapies in Lung Cancers: Current Landscape and Future Prospects
Authors: Feng Xin , Ding Wenqing , Ma Junhong , Liu Baijun , Yuan Hongmei
Published: June 2021

Background:

Lung cancer is the most common malignant cancer worldwide. Targeted
therapies have emerged as a promising treatment strategy for lung cancers.

Objective:

To evaluate the current landscape of targets and find promising targets for future new
drug discovery for lung cancers, this research identified the science-technology-clinical development
pattern and mapped the interaction network of targets.

Methods:

Targets for cancers were classified into 3 groups based on a paper published in Nature.
We searched for scientific pieces of literature, patent documents and clinical trials of targets in
Group 1 and Group 2 for lung cancers. Then, a target-target interaction network of Group 1 was
constructed, and the science-technology-clinical (S-T-C) development patterns of targets in Group
1 were identified. Finally, based on the cluster distribution and the development pattern of targets
in Group 1, interactions between the targets were employed to predict potential targets in Group 2
for drug development.

Results:

The target-target interaction (TTI) network of group 1 resulted in 3 clusters with different
developmental stages. The potential targets in Group 2 are divided into 3 ranks. Level-1 is the first
priority and level-3 is the last. Level-1 includes 16 targets, such as STAT3, CRKL, and PTPN11,
that are mostly involved in signaling transduction pathways. Level-2 and level-3 contain 8 and 6
targets, respectively, related to various biological functions.

Conclusion:

This study will provide references for drug development in lung cancers, emphasizing
that priorities should be given to targets in Level-1, whose mechanisms are worth further exploration.
Architecture, Ability, and Adaptability of Recursive Internetworking
Architecture - A Review
Authors: Neelam Bhushana Samyuel , Shimray Benjamin A.
Published: June 2021

:

The ever-increasing dependency of the utilities on networking brought several cyber
vulnerabilities and burdened them with dynamic networking demands like QoS, multihoming, and
mobility. As the existing network was designed without security in context, it poses several
limitations in mitigating the unwanted cyber threats and struggling to provide an integrated
solution for the novel networking demands. These limitations resulted in the design and
deployment of various add-on protocols that made the existing network architecture a patchy and
complex network. The proposed work introduces one of the future internet architectures, which
seem to provide abilities to mitigate the above limitations. Recursive internetworking architecture
(RINA) is one of the future internets and appears to be a reliable solution with its promising design
features. RINA extended inter-process communication to distributed inter-process communication
and combined it with recursion. RINA offered unique inbuilt security and the ability to meet novel
networking demands with its design. It has also provided integration methods to make use of the
existing network infrastructure. The present work reviews the unique architecture, abilities, and
adaptability of RINA based on various research works of RINA. The contribution of this article is
to expose the potential of RINA in achieving efficient networking solutions among academia and
industry.
Attitude of Village Goverment To Use E-Village Budgeting (Evb) in Compilation of Add : An Integration of Decomposeed Theory Planned Behavior and Risk
Authors: Iswahyudi M , Rosidi Rosidi , Baridwan Zaki
Published: June 2021

This study aims to examine the effect of perceived of ease of use, perceived usefulness, compatibility and perceived risk toward the attitude of e-Village Budgeting (EVB) system user. The use of the mandatory EVB system, as well as the obligation to use information systems in village budgeting, make research on user attitudes appealing to be researched. Data analysis using Partial Least Square (PLS) with warpPLS software version 3.0. The results showed that 1) Perceived Usefulness becomes the determinant factor of user attitude in using EVB system. 2) Perceived ease of use does not affect the attitude of users of EVB system. 3) Compatibility does not affect the attitude of users of EVB system and 4) Perceived risk does not affect the attitude of users of EVB system. This is because the perceived ease of use as a threshold variable and past users who previously used the manual budgeting system also affect the fit or not the EVB.
Health Equity in Artificial Intelligence and Primary Care Research: Protocol for a Scoping Review
Authors: Wang Jonathan Xin , Somani Sulaiman , Chen Jonathan H , Murray Sara , Sarkar Urmimala
Published: June 2021

Background

Though artificial intelligence (AI) has the potential to augment the patient-physician relationship in primary care, bias in intelligent health care systems has the potential to differentially impact vulnerable patient populations.

Objective

The purpose of this scoping review is to summarize the extent to which AI systems in primary care examine the inherent bias toward or against vulnerable populations and appraise how these systems have mitigated the impact of such biases during their development.

Methods

We will conduct a search update from an existing scoping review to identify studies on AI and primary care in the following databases: Medline-OVID, Embase, CINAHL, Cochrane Library, Web of Science, Scopus, IEEE Xplore, ACM Digital Library, MathSciNet, AAAI, and arXiv. Two screeners will independently review all abstracts, titles, and full-text articles. The team will extract data using a structured data extraction form and synthesize the results in accordance with PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines.

Results

This review will provide an assessment of the current state of health care equity within AI for primary care. Specifically, we will identify the degree to which vulnerable patients have been included, assess how bias is interpreted and documented, and understand the extent to which harmful biases are addressed. As of October 2020, the scoping review is in the title- and abstract-screening stage. The results are expected to be submitted for publication in fall 2021.

Conclusions

AI applications in primary care are becoming an increasingly common tool in health care delivery and in preventative care efforts for underserved populations. This scoping review would potentially show the extent to which studies on AI in primary care employ a health equity lens and take steps to mitigate bias.

International Registered Report Identifier (IRRID)

PRR1-10.2196/27799