bluuebunny/crossref_metadata_2025 huggingface dataset:
Commercially available wearable health monitor in dogs is unreliable for tracking energy intake and expenditure
Authors: Sekhar Maya , Rudinsky Adam J. , Cashman Connor , Parker Valerie J. , Kieves Nina R. , Howard James , Winston Jenessa
Published: December 2023

OBJECTIVE

Assess the accuracy of predicted daily energy requirement (pDER) reported by a triaxial accelerometer and activity monitor for dogs (FitBark 2; FitBark Inc) and determine whether the activity monitor accurately estimates the observed daily energy requirement (oDER). We hypothesized that the activity monitor would accurately estimate oDER in dogs and meet standards established for human devices.

ANIMALS

23 dogs between the ages of 1 and 10 years and variable sex, breed, and body weight were enrolled from May 5, 2021, through July 23, 2021.

METHODS

Dogs were weighed before and after the study period to ensure stable body weights. Owners recorded their dogs’ daily caloric intake for the entire 28-day study period while the device monitored physical activity and calculated pDER. oDER was defined as the reported caloric intake required to maintain a stable body weight over a 28-day period. pDER and oDER were compared using Bland-Altman graphs, Passing-Bablock analysis, and Lin’s Concordance correlation analysis. P ≤ .05 was considered significant.

RESULTS

23 apparently healthy dogs completed the study. There was no significant difference between starting body weights and ending body weights (P= .5). The activity monitor overpredicted 28-day pDER compared to 28-day oDER in the majority (18/23, 78.3%) of dogs. Based on Bland-Altman analysis, Passing-Bablok regression, and Lin’s concordance correlation analysis, there was poor agreement between the pDER and oDER.

CLINICAL RELEVANCE

The activity monitors consistently reported inaccurate pDER compared to oDER. Its usability for estimating pDER is of limited clinical and research utility based on the results of this study.
The Research for Aesthetic Quality of Residential Areas in Latvia and Finland
Authors: Ziemeļniece Aija , Īle Una
Published: December 2023

The process of improving the residential areas in Latvia’s cities and their visual and aesthetic quality at the beginning of the 21st century is very slow. Legislation, lack of professionals in institutions, bureaucratic burden of decision-making and other factors create an unnecessary hierarchy. The current instability of the country’s economic and political situation contributes to an imbalance in the psycho-emotional state of society. The permissiveness of society and the desire of citizens to park their cars closer to their front doors are negative features. The construction of multi-storey garages and removing vehicles from courtyards are not a priority for city authorities. The courtyards of apartment blocks built in Latvia in the 1950s–1970s were planned in the post-war years when the number of cars was minimal. The only space in the courtyards was for footpaths, a small play area and a sports field. The rest of the courtyard was lawn and tree planting to provide easy access for emergency vehicles. More than half a century has passed, and today’s task is not easy, as the trees have grown to a great height and are forming shade. In turn, footpaths have lost the purpose to which they led many decades ago. As the political system collapses, the format of living space must change. A new generation is emerging with a new demand for quality. The socio-political and national economic fluctuations are far from easy to stop in the 21st century. There is an apparent lack of cooperation in several planning processes that would ensure the visual and functional quality of urban space at different levels. Latvia’s cities are currently on the path of developing new residential open spaces. Therefore, the study looks at several examples of residential neighbourhoods in Helsinki, Finland, and compares them with residential neighbourhoods in Jelgava, Latvia.
Distributed Generation Allocation in Distribution Network for Energy Losses Reduction
Authors: Melić Emina , Hanjalić Merisa , Šarić Mirza , Hivziefendić Jasna
Published: December 2023

This paper presents a method for distributed generation (DG) allocation in medium voltage (MV) distribution system based on energy loss minimization. The main objective of the research is to design, implement and test a DG allocation (siting and sizing) method and to investigate how optimal DG allocation influence the operational parameters of the system from the Distribution System Operator (DSO) perspective. The problem is formulated as a single objective optimization problem solved by using both genetic algorithm and particle swarm optimization techniques. Model of a realistic Electric Power Distribution System (EPDS) and IEEE 37-bus EPDS are used as test systems. The results confirm that proposed algorithms can be used for practical DG allocation. The research presented contributes to the field as it provides a DG allocation method for energy loss reduction performed on a EPDS which can be applied in realistic planning and regulatory situations using open-source software.
Detection and management of perioperative blood glucose abnormalities†
Authors: Rong Yi , Shuang Wei-Bing
Published: December 2023

Diabetes mellitus is a common chronic disease. With the improvement of living standards, the prevalence of diabetes mellitus in China is increasing. There are now more people with diabetes in China (>100 million) than in any other country. About half of these people with diabetes need to undergo at least one procedure in their lifetime. Diabetic patients have a much higher probability of perioperative dysglycemia than the normal population, which has a great impact on their prognosis. In addition, non-diabetic patients may also have abnormal blood glucose levels due to various reasons during the perioperative period, which will also lead to a series of adverse consequences. This article reviews the perioperative blood glucose management of patients to provide a reference for improving their health status.
Factors related to self-management behavior among persons with mild-to-moderate chronic obstructive pulmonary disease in Wenzhou, China
Authors: Sheng Xiao-Wen , Samartkit Niphawan , Masingboon Khemaradee
Published: December 2023

Objective

To describe the self-management (SM) behavior among persons with mild-to-moderate chronic obstructive pulmonary disease (COPD), and it examines the correlation between COPD knowledge, self-efficacy, perceived social support, and SM behavior among persons with mild-to-moderate COPD in Wenzhou, China.

Methods

A simple random sampling technique was used to recruit 121 persons with mild-to-moderate COPD who visited the respiratory outpatient department of the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, China. Research instruments include a demographic data questionnaire, COPD SM scale, COPD knowledge questionnaire, 6-item chronic disease self-efficacy scale, and perceived social support scale. Descriptive statistics and Pearson’s Correlation were used for data analysis.

Results

The findings show that the mean score of COPD SM scale was 2.70 (SD = 0.45). The Pearson correlation analysis revealed that the COPD knowledge (r = 0.47, P < 0.001), self-efficacy (r = 0.28, P = 0.001), and perceived social support (r = 0.48, P < 0.001) were positively correlated to the COPD SM behavior among persons with mild-to-moderate COPD in Wenzhou, China.

Conclusions

The findings indicate that disease knowledge, self-efficacy, and perceived social support were related to SM behavior in persons with mild-to-moderate COPD, which provides a theoretical basis for developing SM interventions for persons with mild-to-moderate COPD and improving this population’s SM behavior.
Greening the Future: Europe's Renewable Energy Landscape in 2030
Authors: Ciucu Durnoi Alexandra-Nicoleta , Delcea Camelia
Published: December 2023

The increased price of energy and the limited resources of the planet have increased the worldwide attention to renewable energy resources. The purpose of this paper is to present the European context regarding these renewable sources. In addition, the evolution over time of some indicators relevant to this field is described for better shaping the general audience’s understanding of the current status on the renewable sources. Using a statistical approach, the paper ranks the member states in terms of the consumption of renewable resources in areas such as transport and electricity. Throughout the research, it has been noted that there are significant differences between member states. An example to reinforce what was previously described is the fact that, for the share of renewable energy in gross final energy consumption, the minimum value is approximately eight times lower than the maximum. Additionally, forecasting methods of indicators analysed based on historical data were applied to establish the course of EU27 countries for the year 2030, when the implementation period of the Sustainable Development Goals ends.
Does the gender of hospitality employees affect the definition of wages in Spain?
Authors: Sánchez-Cubo Francisco , Mondéjar-Jiménez José
Published: December 2023

Analysing gender differences in key industries is one of today's priorities to achieve a more egalitarian society. In hospitality, the classic approach is through Mincerian regressions or wage decompositions. This paper addresses this issue through Partial Least Squares Structural Equation Modelling (PLS-SEM) and Importance-Performance Map Analysis (IPMA). The results confirm and measure the relations between Human Capital, Labour Conditions, Market, and Wages, and examine the relative importance and performance of each indicator in explaining Wages. Therefore, there are narrow gender differences, and measures are suggested. The main limitation lies in the design of the constructs. This article contributes to the literature by providing an alternative analysis.
Cabinet formation under semi-presidentialism: European countries in comparison
Authors: Lytvyn Vitaliy S. , Romanyuk Anatoliy S.
Published: December 2023

The article demonstrates that the rules and practices of cabinet formation and investitures should be taken into account to better grasp the variety of semi-presidentialism in Europe. This is extremely important, since semi-presidentialism as a constitutional system of government (primarily according to a minimalist approach to the definition) is the most common form of inter-institutional and political relations in European countries. The former is most often understood as a constitutional design of inter-institutional relations with a president popularly elected for a fixed term, as well as with a cabinet headed by a prime minister who are collectively responsible to parliament. Thus, not only presidents and parliaments, but cabinets too play a crucial role in the constitutional and political practice of semi-presidentialism, since the latter are collectively responsible to parliaments (or simultaneously to presidents), but are characterised by distinctive parameters of formation. The assumption and hypothesis are that options of cabinet formation and inter-institutional relations in this regard can structure European semi-presidentialism, even without affecting the definition of this constitutional design, but probably depending on the roles and powers of presidents and parliaments in cabinet formation, as well as types of semi-presidentialism regarding the consideration of who can dismiss the cabinet. Based on comparison and systematisation of the cases of European semi-presidentialism, it is justified that cabinet formation (including within various types and consequences of parliamentary votes of investiture in cabinets, as well as their absence) is typically focused on a junction of relations between presidents and parliaments, and are likely to serve as a classification indicator of semi-presidentialism. This is important for constitutional engineering, since detailing the optionality of semi-presidentialism as a constitutional design and system of government, particularly regarding cabinet formation, should extend the horizons, as well as systematise the idea of the options and effects of various institutional designs (in addition to presidentialism and parliamentarism) and political regimes (including democratic, autocratic and hybrid).
The Impact of Electoral Gender Quotas on Women’s Political Participation in Bosnia and Herzegovina
Authors: Merdanović Ajla Van Heel , Delalić Selma
Published: December 2023

Although representing half of the world population, women remain largely excluded from political power and government structures. Various strategies have been introduced to increase women’s political representation, including electoral gender quotas. This paper explores the impact of electoral gender quotas on women’s quantitative participation in politics of Bosnia and Herzegovina, analysing quota impact in combination with other related factors, such as the quota design, implementation and broader political context. A diversity of techniques has been used to collect a combination of quantitative and qualitative data, including academic resources collection and analysis, desk research, statistical data analysis and online questionnaire. The paper argues that electoral gender quotas have generally had a positive impact on getting women elected in BiH, though their efficacy depends on their formulation and other aspects of electoral law. Still, quantitative representation of women is not sufficient to facilitate their agency in politics. Social attitudes also continue to affect the electoral success of women once they secure a spot on the candidate list. Therefore, quotas must be implemented within a broader democratic, accountable and gender-sensitive political context to deliver qualitative representation of women in politics. Finally, the paper offers concrete recommendations to promote women’s political participation in BiH.
Abdominal Wall Endometriosis at the Cesarean Section Scar
Authors: Rexhepi Meral , Asani Learta Veliu , Mulaki Luljeta , Koprivnjak Kazimir , Azemi Majlinda
Published: December 2023

Abdominal wall endometriosis is atypical localization of the extra-pelvic endometriosis with non-specific symptoms and is difficult for diagnosis. Cesarean scar endometriosis (CSE) is the most common type of abdominal wall endometriosis, which usually develops after obstetric operations. We report a case of a 33-year-old woman who had two previous cesarean sections presented with a mass in the subcutaneous tissue of the abdominal wall, approximately 4 cm superior to the Pfannenstiel incision, 5 years after her second lower segment caesarean section. The classic clinical presentation, imaging findings on ultrasonography and computed tomography are analyzed. Treatment with local surgical excision of the mass is discussed. The diagnosis was confirmed with histopathological analysis of the surgical sample. When it comes to the limited painful lesion in the subcutaneous tissue at the cesarean scar, with a pain intensifying during menstruation, the physician should consider cesarean scar endometriosis in women of reproductive age with a history of cesarean section.
Direct Simple Computation of Middle Surface Between 3D Point Clouds and/or Discrete Surfaces by Tracking Sources in Distance Function Calculation Algorithms
Authors: Kósa Balázs , Mikula Karol
Published: December 2023

In this paper, we introduce novel methods for computing middle surfaces between various 3D data sets such as point clouds and/or discrete surfaces. Traditionally the middle surface is obtained by detecting singularities in computed distance function such as ridges, triple junctions, etc. It requires to compute second order differential characteristics, and also some kinds of heuristics must be applied. Opposite to that, we determine the middle surface just from computing the distance function itself which is a fast and simple approach. We present and compare the results of the fast sweeping method, the vector distance transform algorithm, the fast marching method, and the Dijkstra-Pythagoras method in finding the middle surface between 3D data sets.
تشخيص مستوى تطبيق أتمتة العمليات التنظيمية وأبعادها في وزارة التعليم العالي والبحث العلمي دراسة إستطلاعية لآراء عينة من القيادات الإدارية في ديوان وزارة التعليم العالي والبحث العلمي في أقليم كوردستان
Authors: Hussein Ali Blani Zaid , Qasim Hussein Sinan
Published: December 2023

يهدف البحث الحالي إلى الكشف عن مستوى تطبيق أتمتة العمليات التنظيمية وأبعادها المتمثلة بـ: (التبادلية البينية، التمثيل الإفتراضي، اللامركزية، الإستجابة في الوقت المحدد، التوجه نحو الخدمة، النمطية) من خلال إستطلاع آراء عينة من القيادات في ديوان وزارة التعليم العالي والبحث العلمي لحكومة أقليم كوردستان العراق، في ظل التطورات التكنولوجية المستمرة والمتزايدة بشكل هائل وفي ظل رغبة المنظمات والحكومات في التسريع من إنجازها للوظائف والأنشطة الخاصة بها والتقليل من الوقت والتخلص من الروتين والأنشطة المتكررة، وتم اختيار عينة بلغت (41) قيادياً في الوزارة المبحوثة تجاه متغير البحث وأبعاده الفرعية عن طريق إستمارة إستبيان الكترونية والتي تم تحليل بياناتها باعتماد (الحزمة الإحصائية للعلوم الإجتماعية – SPSS/V26). وأسفرت نتائج البحث عن أن أتمتة العمليات التنظيمية يتم تطبيقها بدرجة متوسطة في وزارة التعليم العالي والبحث العلمي مما يعكس مواقف إيجابية إلى حدٍ ما من قبل الأفراد عينة البحث في زيادة الإهتمام بالأتمتة في الأنشطة والعمليات الخاصة بالوزارة المبحوثة وأداء المهام بشكل آلي ومؤتمت، كما وأشارت النتائج إلى وجود إتفاق وبشكل مرتفع على بُعدي (التبادلية البينية) و (النمطية)، مما يشير إلى أهمية هاذان البُعدان من وجهة نظر القياديين في الوزارة المبحوثة، وقدم البحث عدداً من المقترحات من أهمها قيام الوزارة المبحوثة بتوفير البنية التحتية اللازمة لتطبيق أتمتة العمليات التنظيمية، من خلال زيادة الإهتمام بتوفير أجهزة الحواسيب الحديثة والبرامج والتطبيقات اللازمة في تطبيق هذا النهج ودعم الأنشطة والوظائف الخاصة بها، وأيضاً إشراك القياديين في الوزارة المبحوثة في دورات تدريبية خاصة بمجال الأتمتة ونشر ثقافة تطبيق أتمتة العمليات التنظيمية في الوزارة من خلال الندوات وورش العمل والمحاضرات والمؤتمرات العلمية للتطرق إلى أهمية هذا النهج والفوائد المتحققة من جراء إستخدامه وتطبيقه في مجال أعمالهم ووظائفهم، وتضمن البحث الحالي أربعة محاور، خُصص الأول لمنهجية البحث، أما الثاني فيتطرق إلى الإطار النظري، بينما يقدم المحور الثالث الجانب الميداني، وفي المحور الرابع يتم عرض الإستنتاجات والمقترحات.
Impact of Regulating Inadequate Local Tax Types on Fiscal Independence
Authors: Muja'hidah Muja'hidah , Syamsuddin Adiesty S. P.
Published: December 2023

The autonomy of a region is measured by its ability to generate and finance income without relying on the central government. The effective operation of the government necessitates a budget and different regions possess the authority to impose taxes in generating revenue. This is stipulated in Law Number 1 of 2022 pertaining to the Financial Relations Between the Central and Local Governments. In this Law, local governments are prohibited from levying new types of taxes. Furthermore, only the specified types can be selected and should be established in the form of local regulations (Perda). The selection requires that the tax objects exist and have sufficient potential to increase Local Revenue (PAD) and fiscal independence. Therefore, this study aimed to understand and analyze the meaning of regulating tax types for autonomous regions and to analyze the implications of inadequacy on fiscal independence. Normative-juridical research type is used with legislation, conceptual, and historical approaches. The result shows that the implication of inadequate tax types to be collected can weaken fiscal decentration. This is because the inadequate tax object does not make a significant contribution to increasing PAD. Therefore, a study in the form of a feasibility study is needed to map the potential of local taxes before stipulating the type in the regulation.
Quorum sensing en Pseudomonas Aeruginosa y su relación con algunas patologías en la medicina
Authors: Coutiño Ricardo , Hernández Abel , Morales Ma. Guadalupe , Arias Dana , Ahumedo Maicol , Vivas Reyes Ricardo
Published: December 2023

Las bacterias se organizan en sistemas dinámicos y complejos que interactúan entre sí, coexisten e intercambian información de forma coordinada, este mecanismo de comunicación de las bacterias se conoce como el quorum sensing. Mediante este mecanismo las bacterias pueden conocer su concentración en un ambiente determinado y decidir el momento en el que se va a poner en marcha la expresión de un determinado conjunto de genes con el fin de desarrollar una respuesta concreta y de forma simultánea y de esta forma aumentar las probabilidades de sobrevivir en diferentes ambientes. El Quorum Sensing se ha relacionado con muchas patologías humanos, animales y vegetales, por lo cual se ha convertido en un nuevo blanco para el desarrollo de antimicrobianos, siendo el área de la salud humana la más interesada en comprender el mecanismo y buscar alternativas diferentes para el tratamiento de enfermedades.
FATORES DE RISCOS PARA MORTALIDADE INFANTIL POR ASFIXIA NÃO INTENCIONAL EM BEBÊS
Authors: Oliveira Juliana Bezerra de , Lima Hilderlânia de Freitas , Lima Liene Ribeiro de , Sousa Caroline Ribeiro de , Chaves Anne Fayma Lopes
Published: December 2023

Define-se asfixia como o cessamento do aporte de oxigênio no organismo, seja advindo da falta de oxigênio ou da interrupção das vias aéreas externas e internas. Globalmente, a asfixia não intencional ainda é um grave problema de saúde pública, pois a asfixia acidental e estrangulamento no leito apresenta-se como principal causador de óbito em crianças menores de 5 anos e grande parte dessas mortes estão ligadas diretamente a hábitos e práticas de sono inseguro. O artigo tem como foco refletir sobre os fatores de riscos para mortalidade infantil por asfixia não intencional em bebês. Quanto à metodologia utilizada, trata-se de estudo teórico-reflexivo, na qual desenvolveu-se uma revisão de literatura em bases de dados do Ministério da Saúde, Secretaria de Vigilância em Saúde (SVS) e na Biblioteca Virtual em Saúde (BVS). Após a leitura dos resumos e compilação dos materiais, os documentos selecionados foram lidos na íntegra, seguidos da análise e identificação dos elementos convergentes para a reflexão. Os resultados foram apresentados descritivamente em três categorias, a saber: Cenário mundial sobre a asfixia acidental e estrangulamento no leito; Fatores de risco para asfixia acidental e estrangulamento no leito; assistência profissional frente asfixia acidental e estrangulamento no leito. Como fatores de risco os achados demonstram que a posição prona, lateralizada, compartilhamento de cama, dormir com o filho após ingesta de substâncias química, adormecer em superfícies inseguras, objetos no ambiente no ambiente do sono, uso em excesso de roupa de cama, edredom e colchões macios. Outro fator de risco existente e denota preocupação são os grupos em situação de vulnerabilidade social, idade mais jovem, sem ou baixa escolaridade, baixo nível econômico e famílias que vivem amontoadas, esse perfil são mais propícias a executar ações de mais riscos para o bebê. As práticas de sono inseguro são bastante comuns e difundidas nos lares, dentre os cuidados fundamentais para prevenção de asfixia no ambiente do sono destaca-se a abstenção de objetos no berço, o não compartilhamento de cama. Essas condutas incorretas são realizadas na sua grande maioria por mães jovens, negras, com baixa escolaridade e em situações de vulnerabilidade social. Torna-se necessário pesquisas voltadas para a asfixia acidental e estrangulamento no leito, juntamente com a qualificação dos profissionais da saúde sobre as novas práticas atualizadas do ambiente do sono seguro conduzida pela Academia Americana de Pediatria.
O IMPACTO DO DESCARTE INCORRETO DE MÁSCARAS DESCARTÁVEIS EM UM CENÁRIO PANDÊMICO DA COVID-2019
Authors: Bastos Robert de Sousa , Marques Karen Pereira , Silva Victória Mayara Araújo da , Gadelha de Oliveira Edilene
Published: December 2023

As máscaras descartáveis foram itens essenciais para a preservação da saúde durante pandemia da COVID-19. Apesar disso, o descarte incorreto pode prejudicar tanto o meio ambiente quanto pôr em risco à saúde da população, pois as máscaras são fontes de disseminação do novo coronavírus. Buscou-se analisar o descarte de máscaras pela população durante o período de pandemia. Inicialmente, foi realizada uma revisão da literatura em bases de dados da SciELO, PubMed e Portal BVS sobre o tema. Além disso, este descarte foi avaliado a partir de duas pesquisas de opinião on-line com alunos de uma instituição de Ensino Superior na cidade de Fortaleza, Ceará, a partir de um link do Google Forms, o qual foi divulgado nas redes sociais, sobre como os estudantes realizavam o descarte de máscaras (Pesquisa de Opinião 1) e quantas máscaras descartáveis utilizavam por semana (Pesquisa de Opinião 2). A primeira pesquisa de opinião demonstrou que apenas 11% dos alunos descartavam corretamente as máscaras enquanto na segunda pesquisa, foi observado que uma população de 30 alunos produzia 166 máscaras descartáveis por semana. Assim, foi evidenciado que a maior parte dos alunos não tinham conhecimento sobre o descarte correto de máscaras, demonstrando a necessidade de uma divulgação mais efetiva sobre o descarte recomendado pelo órgão de Vigilância Sanitária. Além disso, as máscaras, quando descartadas de maneira incorreta, podem ocasionar riscos à saúde da população e ao meio ambiente, destacando-se a necessidade de reavaliar ações que busquem sensibilizar a população sobre o seu manejo correto.
Decarboxylative C N coupling of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks
Authors: Ma Xiaoshen , Chen Joanna , Gaskins Bryce
Published: December 2023

Described herein is our effort towards achieving the decarboxylative functionalization of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks. When compared with the non-fluorinated bicyclo[1.1.1]pentane (BCP) analogues, we discovered divergent reactivities. This is the first successful decarboxylative coupling of BCP-F2 building blocks reported via photoredox mechanism.
N–Cα Bond Cleavage Catalyzed by a Multinuclear Iron Oxygenase from a Divergent Methanobactin-like RiPP Gene Cluster
Authors: Chioti Vasiliki T. , Clark Kenzie A. , Seyedsayamdost Mohammad R.
Published: December 2023

DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). Three members, MbnB, TglH, and ChrH, have been characterized to date and shown to catalyze unusual and complex transformations. Using a co-occurrence-based bioinformatic search strategy, we recently generated a sequence similarity network of MNIO-RiPP operons that encode one or more MNIOs adjacent to a transporter. The network revealed >1,000 unique gene clusters, evidence of an unexplored biosynthetic landscape. In this work, we assess an MNIO-RiPP cluster from the network that is encoded in proteobacteria and actinobacteria. The cluster, which we have termed mov (for methanobactin-like operon in Vibrio), encodes a 23-residue precursor peptide, two MNIOs, a RiPP recognition element, and a transporter. Using both in vivo and in vitro methods, we show that one MNIO, homologous to MbnB, installs an oxazolone-thioamide at a Thr-Cys dyad in the precursor. Subsequently, the second MNIO catalyzes N–Cα bond cleavage of the penultimate Asn to generate a C-terminally amidated peptide. This transformation expands the reaction scope of the enzyme family, marks the first ex-ample of an MNIO-catalyzed modification that does not involve Cys, and sets the stage for future exploration of other MNIO-RiPPs
A Computational Investigation on Eumelanin-Drug Binding in Aqueous Solution
Authors: Soltani Sepideh , Roy Anupom , Urtti Arto , Karttunen Mikko
Published: December 2023

Melanin is a widely found natural pigment serving multiple physiological functions and having numerous applications in industries and pharmaceuticals. Due to the diverse structural properties of melanin, drug molecules exhibit varying degrees of affinity towards it. Consequently, drug molecules binding to melanin, including eumelanin, possess significant implications for drug delivery, biodistribution, and the treatment of various diseases. Here, we investigate allosteric binding between drugs and eume- lanin using computational techniques such as molecular dynamics (MD) simulations, density functional theory (DFT) calculations, and free energy calculations. Eumelanin, composed of DHI and DHICA molecules, was utilized in different systems, including aggregated and random arrangements, with the addition of neutral or charged eume- lanin and selected drug molecules (chloroquine, levofloxacin, timolol, methotrexate, and diclofenac). The MD simulations revealed conformational changes in both eumelanin and drug molecules upon interaction along with the creation of binding sites or cavities. Evaluation of binding free energy through Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA) calculations indicated that neutral timolol and charged di- clofenac exhibited the strongest binding to DHI aggregated bundles, while both neutral and charged methotrexate showed the strongest binding in random DHI systems. In contrast, neutral and charged chloroquine displayed the strongest binding in random systems with DHICA (neutral and charged) respectively. Following MD simulations, DFT calculations were employed to further investigate the strength of drug-eumelanin binding. By utilizing the drug-eumelanin poses obtained from MD simulations, DFT calculations demonstrated that the binding strength is influenced by the structural orientation and conformation of both the drug and eumelanin molecules. Overall, drug-eumelanin binding depends on various factors, including conformational changes in both the drug and eumelanin, the charges of the molecules, the presence of binding sites (especially in DHI eumelanin), the occurrence of π-π and hydrogen bond interactions, and the surrounding solvent environment.
Pyrylium- and pyridinum-based ionic liquids as friction modifiers for greases
Authors: Chacon Teran Miguel , Moustafa Cinderella , Luu Joanne , Martini Ashlie , Findlater Michael
Published: December 2023

The use of ionic liquids as lubricants or lubricant additives has been studied extensively over the past few decades. However, the ionic liquids considered for lubricant applications thus far have been part of a limited structural class of phosphonium- or imidazolium-type compounds. Here, new pyrylium- and pyridinium-based ionic liquids bearing long alkyl chains were prepared and evaluated as friction and wear-reducing additives in naphthenic greases. The physical properties of the synthetic ionic liquids and additized-naphthenic grease were measured. The tribological performance of the greases was measured using standard benchtop tests and shown, in some cases, to decrease friction compared to the base grease. The compatibility of the synthetic ionic liquids with the naphthenic greases is tentatively proposed to be a result of molecular structure and its potential influence on miscibility and tribological performance.
Tax Heterogeneity and Misallocation
Authors: Kaymak Barış , Schott Immo
Published: December 2023

Companies face different effective marginal tax rates on their income. This can be detrimental to allocative efficiency unless taxes offset other distortions in the economy. This paper estimates the effect of tax rate heterogeneity on aggregate productivity in distorted economies with multiple frictions. Using firm-level balance-sheet data and estimates of marginal tax rates, we find that tax heterogeneity reduces total factor productivity by about 3 percent. Our findings highlight the positive correlation between marginal tax rates and other distortions to capital and especially labor. This implies that tax rate heterogeneity exacerbates the distortionary effects of other frictions in the economy.
Reviews
Authors: Smith D. F. , Brosnan Peter
Published: December 2023

Reviews of Management Characteristics and Labour Conflict and Working Together
Use R for data analysis and research
Authors: Lillis David
Published: December 2023

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Envisioning science: Marie Curie’s journey from Poland to Paris
Authors: Odlin Sue , Fleming Jean
Published: December 2023

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Editorial
Authors: Bradford-Grieve Janet , Petrey Allen
Published: December 2023

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Opening Address
Authors: Mapp Wayne
Published: December 2023

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The wider roles of science and innovation
Authors: Gluckman Peter
Published: December 2023

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North Pole South Pole: The epic quest to solve the great mystery of Earth’s magnetism
Authors: Petrey Allen
Published: December 2023

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Test Deposit; please ignore
Authors:   , Atkins Ori
Published: December 2023

Testing
INTERDISCIPLINARY REVIEW OF PERI-URBAN AREA TO BUILD A GEOGRAPHY LEARNING EXPERIENCE
Authors: Singkawijaya Elgar Balasa , Maryani Enok
Published: December 2023

Interdisciplinary connects disciplines and without changing from other disciplines. Studying peri-urban areas for students requires skills as well as support in learning geography. The purpose of this writing is to review various literature about peri-urban as a form of interdisciplinary analysis learning for students. Literature review is used to identify findings in various literary studies on the scope and topics faced. The results of interdisciplinary studies of peri-urban science of the region are location as well as the dynamics of the use of agricultural land in non-agricultural also the activity of transportation by mobility recycling, demography there is population dynamics in quantity and quality, sociology there is dynamics social life of the community and the economy there is community activity in utilizing resources. The learning experience of the interdisciplinary review is the digestion of the peri-urban area in its spatial visibility as well as the range of its activities and generates a different geographical learning experience.
FLOOD DISASTER PREPAREDNESS STUDY IN BANJAR CITY, WEST JAVA
Authors: Safira Roro Afifah , Adiputra Agung
Published: December 2023

Flooding is a very common natural disaster in Indonesia. It is necessary to have a disaster risk management programme. This study aims to determine the disaster preparedness of the community for flood in the city of Banjar, West Java. Data were collected from the city government, regional disaster management agency, non-governmental organisations, BPS, earth shape maps from InaGeoportal, vulnerability map data, vulnerability maps and risk maps from the National Disaster Management Agency, and literature in the form of journals and books. The data collection techniques used by the researchers included questionnaires and documentation. The method of data analysis used was descriptive percentage and scoring analysis to analyse the frequency distribution of the level of preparedness of the community in the face of flood disasters.The data was obtained by providing questionnaires to the community which were filled in by the respondents and then calculating the total frequency of correct answers from each respondent. It can be seen that Banjar city has a high level of flood hazard, vulnerability and capacity, which means that it is important to take preparedness measures to reduce the adverse effects and anticipate the increase of recurrent floods.
PANJI DALAM TRADISI SENI PERTUNJUKAN: Alih Estetika dari Keraton Merasuki Estetika Kerakyatan
Authors: Prakosa Rohmat Djoko
Published: December 2023

Panji in the performing arts tradition has a big role. The diversity of forms and types of performances

expresses the Panji cycle on the theme of wandering/wandering patriotic, romantic. There is an aesthetic

transfer from palace aesthetics to popular aesthetics, research into this aesthetic transfer needs to be

carried out to obtain aesthetic diversity. So it is necessary to explore the variants formed by local and

folk traditions. To explore Panji’s cultural diversity in performing arts, a literature study is needed to

approach Panji from the perspective of performing arts history. Direct observation of the forms and types

of Panji performances, and observation of audio-visual documents, portraits and social media broadcasts

about Panji. The results of the literature study and observations made can be described as the story of

Panji in various forms of performance aesthetic expression. A variety of aesthetic performances of theatre,

music, dance and visual aesthetic expressions. Broadly speaking, the aesthetics of the story of Panji is told

in a classical aesthetic that is developed as a palace tradition and is embodied in the populist aesthetics

that are spread across various areas of local populist culture.

Keywords: Panji, tradition, aesthetics, performance
The Use of Immersive Technologies as a Representation Tool in the Protection of Archaeological Heritage
Authors: ÖZTÜRK Merve
Published: December 2023

The preservation of the archaeological heritage with appropriate techniques and methods ensures that it is transferred to future generations in a sustainable way. Various laws, charters and regulations at the national and international level serve as a guide for the right conservation approaches in these areas. However, ensuring sustainability in the protection of cultural heritage is possible by transferring information to society through correct presentation techniques and creating awareness and consciousness in individuals. With the rapid developments in technology, computer-based visualization techniques are used in the presentation of cultural heritage. It has been seen in digital applications that started to be developed in the 2000’s that immersive technologies such as VR and AR, which are applied in fields such as education, health, automotive, entertainment, etc., can be used effectively in the presentation of cultural heritage. In this article, international steps taken in the protection of archaeological heritage and immersive technologies are mentioned, the purposes of using these technologies as a presentation technique in the protection of archaeological heritage are classified and evaluated through examples. Technologies such as VR and AR have been found to be an effective tool in the representation of archaeological heritage and it is aimed that the examples presented will have an encouraging effect for more effective studies in the future.
Local Governance and Entrepreneurship in Tourism – a Comparative Analysis of Two Tourist Destinations
Authors: Calisto Maria de Lurdes , Costa Teresa , Afonso Victor Alves , Nunes Catarina , Umbelino Jorge
Published: December 2023

Literature suggests that local governance might encourage the emergence of innovative businesses. Little is known about that relationship in the context of tourism, although literature suggests governance as a way to deal with the problems of tourism destinations. Additionally, studies in entrepreneurship seldom focus on tourism. This study addresses these gaps by exploring the role of local governance in tourism entrepreneurship. The research strategy of the study is qualitative, using focus groups and semi-structured interviews with diverse local and regional stakeholders, from entrepreneurs to policymakers. Two municipalities in the Metropolitan Area of Lisbon serve as case studies. The differences in the entrepreneurial ecosystems of both territories relate to their distinctive stages of development as tourism destinations. Results suggest that the "good governance" model prevails but that a "one size fits all" approach is not helpful. Results also suggest the need for local governance models to evolve into modes of multi-level network governance, incorporating regional interaction and integration; and recognising participation as the key to democratic legitimacy, transparency, and effectiveness of public policies. With multi-level governance, public administrations at different levels of government are responsible for opening the decision-making process to other relevant actors in society. The study's theoretical contribution concerns the need to investigate hybrid governance models for tourism entrepreneurship. For practitioners (i.e., local decision-makers), this study highlights the advantages of flexibility and a multi-level approach to governance.
Business KPIs Based on Compliance Risk Estimation
Authors: Cernisevs Olegs , Popova Yelena , Cernisevs Dmitrijs
Published: December 2023

The issue of KPI selection is urgent for sustainable business organization including the financial sector. There are numerous studies devoted to KPIs; however, the European Central Bank (European Central Bank, 2023) insists on the necessity of revising the methodology to improve it and make it based on risk and behavior aspects. This research is an attempt to meet the new vision of the ECB. The authors develop a new approach to the selected KPIs of financial institutions on the basis of risk indicators. The PLS-SEM method was used to construct and test the model, representing the company's compliance function and considering various risk categories. The significant relationship between compliance procedures and risk factors was confirmed by the constructed model. The study results not only meet the ECB's new approach but also contribute to the scientific area of choosing sustainable indicators for sustainable business. Empirical analyses from the study decisively highlighted a pronounced correlation between strict compliance with the established rules and proficient risk management practices. In tandem with the ECB's guiding principles, the conclusions derived from this research not only complement the existing body of knowledge but also offer a novel perspective on the essence of the KPI selection. Conclusively, this research confirms the significance of risk-aware KPIs in guiding financial entities toward a trajectory of sustained excellence and growth.
Employer Branding in Tourism: How to Recruit, Retain and Motivate Staff
Authors: Plaikner Alexander , Haid Marco , Kallmuenzer Andreas , Kraus Sascha
Published: December 2023

A fierce "war for talent" has emerged, particularly in the tourism industry, with labour shortages and high turnover rates. This situation challenges employers to secure strategic competitive advantage through their most vital asset, people. Simultaneously, firms must invest in their human capital to increase their value, heightening the significance of employer branding. This paper hence investigates employer branding and does so in the unique context of family businesses, the dominant form of tourism firms, where employer branding takes on a distinct dimension as the family's influence fuses corporate and familial identities. Extending prior research findings that indicate that labour issues often stem from leadership inadequacies and human resource management shortcomings, this paper aims to comprehensively examine these multifaceted challenges and their relevance in the tourism industry. This study employs a qualitative approach utilizing 28 semi-structured interviews with managers, successors, and HR managers in Tyrol, an established tourism region in Austria and Europe. The results reveal that the integration of family values and qualities, as well as the identity and value-based self-image and brand strategies of a business, are important factors in recruiting and retaining employees. This study contributes to deeper insight into the importance, opportunities, and challenges of employer branding in family-run tourism businesses.
EMBROIDERED BISHOI SHAWLS OF RAJASTHAN: THREADS OF ITS HISTORY
Authors: Patel Falguni , Sharma Kriti
Published: December 2023

Rajasthan, the north-western state of India presents a great variety of tangible and intangible cultural heritage. Owing to its unique geographical position in the country, the place is full of historic influences and wealth of art with reflection of cultural diversity along with considerable amount of overlaps in practicing rituals and mode of dressing. The state features a number of embroideries with unique traditions in terms of their costumes and textiles.Amongst the different articles of adornment, the shawls of Bishnoi community of Rajasthan include varieties of tie and dye shawls or embroidered shawls or a combination of both. Growing globalization in the present day and time poses a considerable threat to the survival of traditional craft forms and hence the craft holds no past records regarding the origin of these Bishnoi shawls. Therefore, the objective of the study was to undertake a scientific exploration, of the heritage craft of these shawls which to trace and record the history and origin of the Bishnoi community embroidered shawls. The research under this paper takes an exploratory and descriptive method, both primary and secondary data were collected. Purposive sampling was adopted to visit antique collectors and museums and snowballing technique was used to advance the research further till primary Bishnoi respondents.The study unveiled the opulent and alluring history behind the embroidered shawl which sustains the cultural history of the region in their style of motifs with distinct embroidery motifs illustrating the influence of embroidery from Central Asia.
THE RELATIONS BETWEEN VOCATIONAL SCHOOL STUDENTS’ EMPLOYABILITY, CAREER DECISION SELF-EFFICIENCY, AND PERCEPTIONS OF HUMAN CAPITAL
Authors: KOÇAK Emrah , URAL Ayhan
Published: December 2023

Bu araştırmada, meslek yüksekokulu öğrencilerinin kariyer kararı özyeterlikleri ile istihdam edilebilirlikleri arasındaki ilişkide insan sermayesi düzeylerinin moderatörlük rolünün incelenmesi amaçlanmıştır. Araştırmanın evrenini Mersin
Üniversitesi’nin Sağlık Hizmetleri Meslek Yüksekokulu, Sosyal Bilimler Meslek Yüksekokulu ve Teknik Bilimler Meslek Yüksekokulunda 2021-2022 eğitim öğretim yılında öğrenim görmekte olan ikinci sınıf öğrencileri oluşturmaktadır.
Evrenin tamamına ulaşılabileceği düşünülerek ayrıca bir örneklem belirlenmemiştir. Buna göre evren, 662 öğrenciden oluşmaktadır. Veriler betimsel istatistikler, bağımsız örneklem t-testi, tek yönlü varyans analizi, Pearson korelasyon
analizi ve yol analizi teknikleriyle incelenmiştir. Araştırma bulgularına göre katılımcıların istihdam edilebilirlik algıları, kariyer kararı öz yeterlikleri ve insan sermayesi algıları sırasıyla “katılıyorum”, “kısmen katılıyorum”
ve “kendime oldukça güvenim var” düzeylerinde gerçekleşmiştir. Korelasyon analizlerinde değişkenler arasında pozitif yönlü anlamlı ilişkiler olduğu bulunmuştur. Moderatörlük çözümlemesinde ise kariyer kararı öz yeterliği ile insan
sermayesi algısından elde edilen etkileşim teriminin moderatörlük etkisinin istatistiksel olarak anlamlı ve negatif olduğu sonucuna ulaşılmıştır. Bu durum antagnonistik etkileşim bulgusunu ortaya koymaktadır. Bu bulgu, araştırmanın
moderatör değişkeni olarak kurgulanan insan sermayesi algısı arttıkça, kariyer kararı öz yeterliğinin istihdam edilebilirlik üzerindeki etkisinin azaldığına işaret etmektedir. Bu durumun nedenlerine ilişkin olarak daha derin bir
kavrayış sağlayabilmek adına araştırmanın farklı çalışma grupları üzerinde farklı araştırma yöntemleri ile de gerçekleştirilmesi önerilmektedir.