bluuebunny/crossref_metadata_2025 huggingface dataset:
Curcumin Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting NLRP1-dependent Neuronal Pyroptosis
Authors: Huang Lifa , Li Xu , Liu Yajun , Liang Xiaolong , Ye Hui , Yang Chao , Hua Lin , Zhang Xin
Published: June 2021

Background:

Cerebral ischemia-reperfusion injury is caused by a blood reperfusion injury
in the ischemic brain and usually occurs in the treatment stage of ischemic disease, which can
aggravate brain tissue injury.

Objective:

Curcumin was reported to exert a good therapeutic effect on neural cells against ischemia-
reperfusion injury, However, the mechanism is not clear.

Methods:

In this study, Oxygen-Glucose Deprivation (OGD) model of fetal rat cerebral cortical
neurons and the Middle Cerebral Artery Occlusion (MCAO) model of rats were employed to mimic
cerebral ischemia-reperfusion injury in vitro and in vivo, respectively.

Results:

We confirmed that curcumin has a promotive effect on neuronal proliferation and an inhibitory
effect on neuronal pyroptosis. Furthermore, we found that curcumin could improve cerebral
infarction. The results of western blotting showed that curcumin down-regulated the expression
of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and
pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1),
gasdermin D (GSDMD), IL-1β, IL-6, TNF-α, and iNOS proteins in OGD and MCAO models. NLRP1-
dependent neuronal pyroptosis played an important role in cerebral ischemia-reperfusion
injury.

Conclusion:

Curcumin could effectively inhibit NLRP1-dependent neuronal pyroptosis by suppressing
the p38 MAPK pathway and therefore exerted neuroprotective effects against cerebral ischemia-
reperfusion injury.
Current Clinical Psychopharmacology in Borderline Personality Disorder
Authors: Del Casale Antonio , Bonanni Luca , Bargagna Paride , Novelli Francesco , Fiaschè Federica , Paolini Marco , Forcina Francesca , Anibaldi Gaia , Cortese Francesca Natalia , Iannuccelli Alessia , Adriani Barbara , Brugnoli Roberto , Girardi Paolo , Paris Joel , Pompili Maurizio
Published: June 2021

Background:

Patients with Borderline Personality Disorder (BPD) manifest affective and
behavioral symptoms causing personal distress, relationship difficulties, and reduced quality of life
with global functioning impairment, mainly when the disease takes an unfavorable course. A substantial
amount of healthcare costs is dedicated to addressing these issues. Many BPD patients receive
medications, mostly those who do not respond to psychological interventions.

Objective:

Our aim was to assess the efficacy of the most used strategies of pharmacological interventions
in BPD with a comprehensive overview of the field.

Methods:

We searched the PubMed database for papers focused on the most used psychotropic
drugs for BPD. We included randomized controlled trials and open studies in adult patients with
BPD, focusing on the efficacy and tolerability of single classes of drugs with respect to specific
clinical presentations that may occur during the course of BPD.

Results:

Specific second-generation antipsychotics (SGAs) or serotonergic antidepressants can be
effective for different core symptoms of BPD, mainly including mood symptoms, anxiety, and impulse
dyscontrol. Some atypical antipsychotics can also be effective for psychotic and dissociative
symptoms. Specific antiepileptics can be useful in some cases in treating different BPD symptoms,
mainly including mood instability, impulsiveness, and anger.

Conclusions:

No medication is currently approved for BPD, and clinicians should carefully assess
the benefits and risks of drug treatment. Further studies are needed to identify specific personalized
treatment strategies, also considering the clinical heterogeneity and possible comorbidities of BPD.
Recent Advancements and Patents on Buccal Drug Delivery Systems: A Comprehensive Review
Authors: Srivastava Nimisha , Aslam Sahifa
Published: June 2021

:

The major requirement for a dosage form to be successful is its ability to penetrate the site of application and the bioavailability of the drug released from the dosage form. The buccal drug delivery is an influential route to deliver the drug into the body. Here, in this context, various novel approaches that include lipoidal carriers like ethosomes, transferosomes, niosomes etc and electrospun nanofibers are discussed, with respect to buccal drug delivery. These carriers can be easily incorporated into buccal dosage forms like patches and gels that are responsible for increased permeation across the buccal epithelium. The in vivo methods of evaluation on animal models are conscribed here. The novel biocarriers of lipoidal and non-lipoidal nature can be utilized by loading the drug into them, which are helpful in preventing drug degradation and other drawbacks as compared to conventional formulations. The globally patented buccal formulations give us a wide context in literature about the patents filed and granted in the recent years. When it comes to patient compliance, age is an issue, which is also solved by the buccal route. The pediatric buccal formulations are researched for the customization to be delivered to children. Diseases like mouth ulcers, oral cancer, Parkinson’s disease, aphthous stomatitis etc. have been successfully treated through the buccal route, which infers that the buccal drug delivery system is an effective and emerging area for formulation and development in the field of pharmaceutics.
Formulation and Evaluation of Cassia tora Phytosomal Gel Using Central Composite Design
Authors: Corrie Leander , Gundaram Raghunandan , Kukatil Latha
Published: June 2021

Background::

Cassia tora has been classified as an antifungal agent, but no
optimized formulation for improved drug penetration has been developed.

Objective::

The present work aimed to formulate Cassia tora extract (CTE) phytosomal
gel that could be used for its antifungal effects and improved therapeutic activity.

Materials and Methods:

The CTE phytosomes were formulated by varying the concentration
of lecithin (0.15-0.25% w/v) and speed of rotation (100-160 rpm). A 22 factorial
design was applied by taking the above two parameters as independent variables and vesicular
size and entrapment efficiency as dependent variables. The phytosomes were also
evaluated for polydispersity index, zeta potential and in vitro drug release. The optimized
phytosomes of CTE were further developed into a gel, the optimized gel was also
evaluated, and the stability studies were conducted.

Results and Discussion:

The optimized CTE phytosome showed a vesicular size of ~
124 nm and entrapment efficiency of 95%. The CTE phytosomes showed a drug release
of 58.79% in 24 hours following the Higuchi order of release. The CTE phytosomes
were formulated into a gel by using 1% Carbopol 934 and were evaluated for pH, viscosity
and homogeneity. The formulated gel showed better penetration than conventional
gel, and stability changes indicated no major changes to the CTE phytosomal gel.

Conclusion:

The optimized gel had better penetration and drug release than the conventional
gel. Its therapeutic activity, therefore, can be enhanced.
Treatment of Persistent Postconcussion Syndrome With Repetitive Transcranial Magnetic Stimulation Using Functional Near-Infrared Spectroscopy as a Biomarker of Response: Protocol for a Randomized Controlled Clinical Trial (Preprint)
Authors: du Plessis Sané , Oni Ibukunoluwa K , Lapointe Andrew P , Campbell Christina , Dunn Jeff F , Debert Chantel T
Published: June 2021

BACKGROUND

Approximately one-third of all concussions lead to persistent postconcussion syndrome (PPCS). Repetitive transcranial magnetic stimulation (rTMS) is a form of noninvasive brain stimulation that has been extensively used to treat refractory major depressive disorder and has a strong potential to be used as a treatment for patients with PPCS. Functional near-infrared spectroscopy (fNIRS) has already been used as a tool to assess patients with PPCS and may provide insight into the pathophysiology of rTMS treatment in patients with PPCS.

OBJECTIVE

The primary objective of this research is to determine whether rTMS treatment improves symptom burden in patients with PPCS compared to sham treatment using the Rivermead postconcussion symptom questionnaire. The secondary objective is to explore the neuropathophysiological changes that occur following rTMS in participants with PPCS using fNIRS. Exploratory objectives include determining whether rTMS treatment in participants with PPCS will also improve quality of life, anxiety, depressive symptoms, cognition, posttraumatic stress, and function secondary to headaches.

METHODS

A total of 44 adults (18-65 years old) with PPCS (>3 months to 5 years) will participate in a double-blind, sham-controlled, concealed allocation, randomized clinical trial. The participants will engage in either a 4-week rTMS treatment protocol or sham rTMS protocol (20 treatments). The left dorsolateral prefrontal cortex will be located through Montreal Neurologic Institute coordinates. The intensity of the rTMS treatment over the left dorsolateral prefrontal cortex will be 120% of resting motor threshold, with a frequency of 10 Hz, 10 trains of 60 pulses per train (total of 600 pulses), and intertrain interval of 45 seconds. Prior to starting the rTMS treatment, participant and injury characteristics, questionnaires (symptom burden, quality of life, depression, anxiety, cognition, and headache), and fNIRS assessment will be collected. Repeat questionnaires and fNIRS will occur immediately after rTMS treatment and at 1 month and 3 months post rTMS. Outcome parameters will be analyzed by a 2-way (treatment × time) mixed analysis of variance.

RESULTS

As of May 6, 2021, 5 participants have been recruited for the study, and 3 have completed the rTMS protocol. The estimated completion date of the trial is May 2022.

CONCLUSIONS

This trial will expand our knowledge of how rTMS can be used as a treatment option of PPCS and will explore the neuropathophysiological response of rTMS through fNIRS analysis.

CLINICALTRIAL

ClinicalTrials.gov NCT04568369; https://clinicaltrials.gov/ct2/show/NCT04568369

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/31308
A murine Staphylococcus aureus fracture-related infection model characterised by fracture non-union, staphylococcal abscess communities and myeloid-derived suppressor cells
Authors:   AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland, Hofstee MI , Riool M , Gieling F , Stenger V , Constant C , Nehrbass D , Zeiter S , Richards RG , Zaat SAJ , Moriarty TF
Published: June 2021

A fracture-related infection (FRI) is a serious complication that can occur after surgical fixation of bone fractures. Affected patients may encounter delayed healing and functional limitations. Although it is well established that Staphylococcus aureus (S. aureus) is the main causative pathogen of an FRI, the pathophysiology of an S. aureus-induced FRI is not well characterised over time. Therefore, an experimental study in mice comparing S. aureus-inoculated and non-inoculated groups was performed that particularly focused on staphylococcal abscess communities (SACs) and host cellular response. C57Bl/6N female mice received a double osteotomy of the femur, which was stabilised using a titanium 6-hole MouseFix locking plate and four screws. Animals were either S. aureus-inoculated or non-inoculated and euthanised between 1 and 28 d post-surgery. Histopathological evaluation showed normal bone healing for non-inoculated mice, whereas inoculated mice had no fracture consolidation and severe osteolysis. Within the bone marrow of inoculated mice, SACs were observed from 7 d, which increased in size and number over time. A fibrin pseudocapsule enclosed the SACs, which were surrounded by many Ly6G+ neutrophils with some Ly6C+ monocytes and F4/80+ macrophages, the majority of which were viable. The abscesses were encapsulated by fibrin(ogen), collagen and myofibroblasts, with regulatory T cells and M2 macrophages at the periphery. Only bone marrow monocytes and neutrophils of inoculated mice displayed functional suppression of T cells, indicative of myeloid-derived suppressor cells. The present study revealed that an FRI in mice is persistent over time and associated with osteolysis, SAC formation and an immunosuppressive environment.
Artículos para consolidar el acervo académico e intelectual
Authors:   Corporación Universitaria Remington, González Carvajal Pedro Juan
Published: June 2021

Editorial volumen 1, número 2 año 2013.
Phospholipase A2 (PLA2) Sequences in Rattus norvegicus Genome
Authors: Kanagaraj Jyothi
Published: June 2021

Phospholipase A2 is enzyme that hydrolyses phospholipids at sn-2 position. This class of enzymes are significant due to their ability to cleave membrane phospholipids and hence causing inflammation. The PLA2 enzymes present in Rattus norvegicus is extensively studied to predict its properties. The Protparam analysis was performed to predict the physical properties like number of amino acids, Theoretical pH, stability index value, aliphatic index value and GRAVY value. The SOPMA analysis predicted its structural properties like the number of alpha-helices and beta-strands. Hence the focus of the present study was to perform a preliminary in silico analysis to identify the PLA2 protein sequences in the genome of Rattus norvegicus.
Print on Air: Result Analysis on Implementation of a Cloud-based Printing Order Management System
Authors: Dhatrak Prajakta
Published: June 2021

Within the span of an undergrad, printing reports is vital whether it is in scholarly assignments, investigate or notes. Be that as it may, the current printing offices are imperfect and time devouring. To overcome these issues, we effectively created a proposed framework to progress the productivity of current printing administrations. This work expounds on the plan and improvement of the printing benefit utilizing android and google Firebase. Amid Covid-19 Widespread, Offline Print shops are encountering major plunges in foot activity. However, this doesn't mean closing shops completely and believe that the circumstances will be the conclusion. Vendors are utilizing the online space to get orders, amid the lockdown. There are numerous existing frameworks for this issue, but there are a few escape clauses in each framework, so there's a requirement for a framework that gives the client to put orders from anyplace any time utilizing the portable application with the assistance of cloud computing. Before setting an order, the purchaser must calculate of fairs, envisioned time of transport must be calculated.
Plant Diseases Detection and Pesticide Suggestion Implementation
Authors: Kunjir Onkar
Published: June 2021

Plant diseases affect the life of not only farmers but also businesses which are dependent on it. Plant disease detection is a computer vision problem which tries to identify the disease splat is infected using an image of a plant leaf. Different kinds of models have been proposed to tackle this problem. This paper focuses on generating small, lightweight and accurate models with the help of deep learning and transfer learning.
Feature based Phishing Website Detection using Random Forest Classifier
Authors: Kadam Sonali
Published: June 2021

In today’s world, one of the most vulnerable security threat which poses a problem to the internet users is phishing. Phishing is an attack made to steal the sensitive information of the users such as password, PIN, card details etc., In a phishing attack, the attacker creates a fake website to make the users click it and steal the sensitive information of users. . In this paper, we propose a feature-based phishing detection technique that uses uniform resource locator (URL) features. This paper focuses on the extracting the features which are then classified based on their effect within a website. The feature groups include address- bar related features, abnormal- based features, HTML – JavaScript based features and domain based features. We plan to use machine learning and implement some classification algorithms and compare the performance of these algorithms on our dataset.
The dynamics of the COVID-19 pandemic and formation of the postcovid period in Russia
Authors: Belyakov N. A. , Trofimova T. N. , Simakina O. E. , Rassokhin V. V. , Serebryakova S. L.
Published: June 2021

The pandemic of the newly coronavirus infection COVID-19 was the test primarily for scientists, experts in epidemiology, infectiology and other fields of medicine participating in addressing the issues of organization and delivery of care, forming up the whole ideology of public health in new conditions. The lecture presents the complex analysis of development of the epidemiologic process, concerning a review of last epidemics, regional features, forecast and modelling approaches, the observers will be able to evaluate demographic, social and medical aspects of evolution. The emphasis is made on the consequences of the transferred infection that directly affect human health, a brief analysis of the clinical manifestations of post-covid syndrome and its expected impact on people, the functioning of all levels of health care, including rehabilitation. The key role of vaccination as the main method of population immunity, prevention of SARS-CoV-2 infection, the development of severe and complicated forms of the disease, as well as domestic manufacturers and manufacturers of several safe and highly effective vaccines has been determined. The article is intended for a wide range of medical professionals, healthcare organizers, government officials and other interested parties.
РОДИНА-PATRIA in Russian and Spanish Verbal Associative Networks
Authors: Sánchez Puig M.
Published: June 2021

The specific national characteristics of stimulus Homeland in Russian and Spanish verbal associative network are described in this article. The contrastive analysis of one of the basic word-model-points, inherent to the Russian and Spanish native speakers, is being investigated for the first time. The qualitative indicators of the performed analysis constitute a kind of thesaurus of the associative norms of the Russian and Spanish languages and, together with the quantitative ones, can be the subject of linguo-psychological comparative analysis and provide additional information about the associative norms, structure, linguistic ability and national character of the speakers of the given language and culture.The theme may be interesting for specialists not only in philology, but also in psychology, sociology, culturology, mass media, commercial advertizing and other spheres connected with human activity.
State’s Responsibility over Forest and Land Fires Causing Transboundary Haze Pollution in the Frame of ASEAN Agreement
Authors: Rizky Fajar Khaify , Suhaidi Suhaidi , Syahrin Alvi , Leviza Jelly
Published: June 2021

This article aims to analyze the state’s responsibility over forest and land fires causing transboundary haze pollution according to the Asean Agreement on Transboundary Haze Pollution. A normative legal method is applied to help answer the problems of transboundary pollution which has been an international concern. The impact of haze pollution resulted from forest and land fires has triggered protests against Indonesian government and urged the sate’s liability as long as the impact of the haze pollution is concerned. Forest and land fires which caused transboundary haze pollution has infilcted losses and damage not only in Indonesia but also in other neighbouring countries, such as Malaysia and Singapore. State responsibility is a fundamental principle in international law applied when a country has violated boundaries, either directly or indirectly, which is harmful to other countries. In international environmental law, tansboudary air pollution caused by forest and land fires is contrary to the principles of international environmental law resulting in a state responsibility responsibility or liability. While responsibility refers to a legally regulated responsibility and the concept of international law, the liability refers to the indemnification of the other party’s loss. As a result of forest and land fires causing transboundary haze pollution, ASEAN member countries have agreed to form an AATHP (ASEAN Agreement on Transboundary Haze Pollution) agreement aiming at preventing and mitigating transboundary haze pollution
The meaning of the infinitely great
Authors: Li Qing
Published: June 2021

The infinitely small is defined as finite length quantity of one
dimension without the sizes of space ,while the infinitely great is
reached by the superpositions or accumulations of infinitely many of the
finite quantity by the way of the change of direction. The change of
direction indicates that there is an leap from a finite quantity to
finite quantities of infinitely many(infinitely great) and the form of
manifestation of infinitely great is one quantitative continuum that can
not be carried out by any algorithms and all parts of space (including
circumferential length) we see is this one quantitative continuum. The
any value is this one quantitative continuum implied the infinitely
great that compresses any quantities outside of it to nothing.
NSAIDs/Nitazoxanide/Azithromycin Immunomodulatory Protocol Used in Adults, Geriatric, Pediatric, Pregnant, and Immunocompromised COVID-19 Patients: A Prospective Observational Study and Case-Series
Authors: Kelleni Mina
Published: June 2021

No treatment protocol of proven
efficacy was approved to manage COVID-19 and we present a novel COVID-19
immunomodulatory protocol basing on our early pioneering article that
justified repurposing nitazoxanide/azithromycin combination for early
cases of COVID-19 which was followed by two articles to justify addition
of non-steroidal anti-inflammatory drugs to nitazoxanide/azithromycin
and recently an article that illustrates the potential immunomodulatory
mechanisms by which all the drugs used might benefit COVID-19 patients
has been published. We have managed more than 50 confirmed and highly
suspected COVID-19 patients, mostly via telemedicine, while fully
presenting a case series of 37 COVID-19 Arab patients including 12
confirmed by PCR and 23 diagnosed by other measures. The patients
included 14 adult males including an immunocompromised patient, 16 adult
females including one lactating, 3 pregnant patients including one
confirmed by PCR as well as 4 children. All patients have received a
short 5-day-regimen of NSAIDs (diclofenac potassium in most of cases,
ibuprofen, lornoxicam, meloxicam, celecoxib, naproxen, ketoprofen or
ketorolac)/nitazoxanide/azithromycin +/- cefoperazone either in full or
in part as illustrated in the manuscript. The primary endpoint of this
protocol was full relief of all serious COVID-19 clinical
manifestations, and it was fully achieved in all patients within two
weeks. Most of the patients treated early have fully recovered during
its described five days; the leucocytic/lymphocytic count was
significantly improved for those with prior leucopenia or
leucocytosis/lymphopenia. No significant adverse effects were reported.
In conclusion, a novel 5-day-protocol to safely and effectively cure
COVID-19 using repurposed immunomodulatory safe and inexpensive FDA
approved drugs is illustrated and we recommend performing sufficiently
powered double blind randomized clinical trials against any current
standard protocol.
Loddet er kastet: Om bruken av innbyggerpaneler i lokalpolitikken
Authors: Arnesen Sveinung , Fimreite Anne Lise , Aars Jacob
Published: June 2021

This chapter examines a citizens’ panel (a ‘mini-public’) that took place in the municipality of Bergen in 2018. We begin by discussing mini-publics as innovative measures to increase participation in political systems. In the literature, the internal quality of the panels – who is recruited and included on the panel and how opinion formation is organized – is emphasized. How mini-publics affect the political/representative political system – the external quality of the panels – has not been studied as thoroughly, and is therefore the analytical starting point for our chapter. In the empirical part of the chapter, we present the panel in Bergen, how it was recruited and organized, and the recommendations it made to decision-makers in the municipality. We also explore how citizens in Bergen assess these sorts of innovative democratic measures. The chapter ends with a discussion of the mini-public’s place in a representative democracy – are mini-publics supplements or alternatives?
Nyheter, sosiale nettverk og lokalpolitisk orientering i lokalvalgkamp
Authors: Karlsen Rune , Steen-Johnsen Kari
Published: June 2021

In this chapter, we examine how voters relate to the local political public sphere through a study of the 2019 Norwegian local election. We ask whether local media and personal networks contribute to what we call “local political orientation”, measured by the degree to which voters consider local issues to be important for their vote choice and using the possibility of giving preference votes. We first study the voters’ overall news consumption in the election campaign, with particular emphasis on the role of social media. Then we investigate to what extent candidates running for election are included in voters’ offline networks (family, friends, acquaintances) and social media networks. Finally, we study whether different patterns of news consumption and offline and online political networks increase voters’ degree of local political orientation. Results show that voters use a wide range of news sources – national, local and social media – and that local media is considered more important in small municipalities. A large proportion of voters have political candidates in their personal network, but almost forty percent of those who have a political candidate as a Facebook friend have no candidate in their offline personal network. Hence, social media contribute to greater ties between voters and candidates in Norwegian local politics. Lastly, local media and personal networks do contribute to local political orientation, as they relate to an emphasis on local political issues and a tendency for giving preference votes (to candidates) at the election.
Hva kjennetegner velgere med høy lokalpolitisk tillit?
Authors: Winsvold Marte
Published: June 2021

Why do some citizens trust in local political actors and institutions while others do not? With data from the Norwegian Local Election Survey 2019, we examine characteristics of citizens with high and low local political trust. The analyses indicate that trust in the different political actors and institutions is closely linked. For example, those who report high trust in the mayor also report high trust in politicians in general, in the municipal council, and in the municipal administration. In other words, people tend to have either high or low trust in the entire local political system. Furthermore, we find that trust in local political systems and actors is associated with a number of individual and contextual factors including the sense of belonging to the municipality, the use of municipal services, and political participation. Trust also seems to be linked to being on the winning team: those who voted for parties that won the election are more trustful than those who voted for parties that that did not win the election.
THE ANALYSIS OF WATER SPEED INFLUENCE IN HOT-WATER DISTRIBUTION SYSTEM ON THE AMOUNT OF HEAT LOSS
Authors:   Technical University of Kosice, Kapalo Peter , Kozak Khrystyna ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Myroniuk Khrystyna ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation
Published: June 2021

One of the main tasks around the world is to reduce energy consumption with constant consumer comfort. The hot water supply system uses a significant part of thermal energy and requires no less attention than the heating or ventilation system. The amount of heat loss from hot water distribution systems is of great importance for the energy consumption of buildings. In winter, part of this heat is used for space heating, in summer they are unused and is considered as lost heat. For this reason, this paper considers the influence of water velocity in the pipe, pipe size, and water temperature on the total heat losses in the insulated hot-water distribution system. The data are presented in tabular and graphical form. A graph of the dependence of the amount of heat loss on the temperature and velocity of hot water is obtained.
THE USE OF AGRICULTURAL BIOMASS AS A SOURCE FOR BIOGAS PRODUCTION
Authors:   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Furdas Yurii , Kozak Khrystyna ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Savchenko Olena ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Lunyk Mariia ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Hensetskyi Mykola ,   Technical and Economic College  of Lviv Polytechnic National University
Published: June 2021

As raw materials in bioenergy can be used agricultural residues formed in the process of harvesting crops and the process of their processing, in particular straw cereals, legumes, corn and sunflower seeds, etc. For energy needs, agricultural biomass is used by burning or processing into solid, liquid, or gaseous fuels. In the production of gaseous fuel in special plants - bioreactors, agricultural waste is formed not only as a source of energy - biogas, but also as excellent fertilizers. In this article, studies have shown that the amount of biogas produced depends on the type of biomass and fermentation time. The largest amount of biogas is produced within 10 days from the date of loading of organic biomass. It was found that the highest daily biogas production is formed from grass and grain silage, the maximum value of which is 1.76 m3. The smallest - from rapeseed silage – 0.33 m3.
EFFECT OF LIMESTONE POWDER ON THE PROPERTIES OF BLENDED РORTLAND CEMENTS
Authors:   Lviv Polytechnic National University, Department of Building Production, Kropyvnytska Тetiana , Нeviuk Iryna ,   PJSC Ivano-Frankivskcement, Stekhna Roksolana ,   Ivano-Frankivsk National Technical University of Oil and Gas, Rykhlitska Oksana ,   Lviv Polytechnic National University, Department of Building Production, Deschenko Lidiia ,   Lviv Polytechnic National University, Department of Building Production
Published: June 2021

The article shows the relation between sustainability and cement manufacture that can be obtained by the replacement of clinker with limestone additive. This decreases the use of energy resources and reduces CO2 emissions in cement production. The issue of partial Portland cement clinker substitution by finely ground limestone in the production of market-oriented types of cement type CEM II is solved on the cement plant PJSC "Ivano-Frankivsk Cement". The indexes of physical-mechanical tests of certified Portland limestone cement with high early strength CEM II/A-LL 42.5 R produced by PJSC "Ivano-Frankivsk Cement" are given. Finely dispersed limestone in Portland-composite cements with slag promotes a more complete synergic effect. It is established, that rapid-hardening blended Portland cements with limestone powder provide technological, technical, ecological, and economic effects in the production of prefabricated and monolithic reinforced concrete.
ASSESSMENT OF ENERGY SECURITY OF HIGHER EDUCATION INSTITUTIONS
Authors:   Lviv Polytechnic National University, Department of Electronics and Information Technology, Pashkevych Volodymyr , Malashkin Maksym ,   Ukraine Energy Association, Zhelykh Vasyl ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Lozynskyy Orest ,   Lviv Polytechnic National University, Department of Electrmehatronics and Computerized Electromechanical Systems
Published: June 2021

The research work is devoted to the survey of the power economy of Lviv Polytechnic National University to assess energy security, to improve the strategy of energy use, and to develop measures for improving the energy security of the university. The first chapter provides a brief description of the proposed method of studying the energy security of the university. It is based on the method of determining 46 indicators according to which five criteria of energy security are formed: Energy efficiency, Energy independence, Energy security, Reliability of heat supply, Economic stability. In the eighth chapter, according to the mentioned indicators the estimates of criteria are calculated and the analysis of their levels is carried out. Based on this analysis, the principles of improving the energy security of the university are proposed.
ADHESION OF BITUMINOUS BINDERS WITH AGGREGATES IN THE CONTEXT OF SURFACE DRESSING TECHNOLOGY FOR ROAD PAVEMENTS TREATMENT
Authors:   Lviv Polytechnic National University, Department of Highways and Bridges, Sidun Iurii , Solodkyy Serhiy ,   Lviv Polytechnic National University, Department of Highways and Bridges, Vollis Oleksiy ,   Lviv Polytechnic National University, Stanchak Svitlana ,   College of National Army Academy named after Hetman P. Sahaidachnyi, Bidos Volodymyr ,   Lviv Polytechnic National University, Department of Highways and Bridges
Published: June 2021

In this article the study is done for the adhesion of aggregates coming from various granite quarries of Ukraine with bituminous binder, namely with bitumen emulsion – for application in surface dressing technology for road pavements treatment. In the article there are used the Ukrainian and European testing methods for determination of adhesion in the “bitumen – aggregate” system. According to the Ukrainian method, there was determined the adhesion of residual binder with the chips surface after boiling in the distilled water and in the solution of glycerin and distilled water. As the European method, for the studies there was used Vialit Plate Shock Test. There were developed three bitumen emulsion formulations.
SOIL-CEMENT PILES FIBER REINFORCED
Authors:   National University «Yuri Kondratyuk Poltava Polytechnic», Novytskyi Oleksandr
Published: June 2021

Problems and insufficient research of the issue of reinforcement of soil-cement piles are revealed. The use of fiber for reinforcing piles made by the deep soil mixing method is proposed. As a result, it is expected to increase the strength of soil cement, which will positively affect the bearing capacity of soil-cement piles on the material. Given the advantages for applications in the studies adopted steel fiber. The program of tests with the application of two-factor matrices of planning of experiment is made. The obtained results showed the degree of influence of fiber reinforcement on the strength of soil cement. Practical results have been obtained that can be used for implementation in the process of installation of soil-cement piles.
INVESTIGATION THE EXERGETIC EFFICIENCY OF REFRIGERANT R290 (PROPANE) APPLICATION FOR WORK OF AIR SPLIT-CONDITIONER
Authors:   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation, Labay Volodymyr , Yaroslav Vitaliy ,   Lviv Polytechnic National University, Department of Heat and Gas Supply and Ventilation
Published: June 2021

In air split-conditioners, the degree of their energy perfection must be determined based on the analysis of their exergy efficiency. In this article the innovative mathematical model developed by the authors for exergetic analysis of the work of air split-conditioners. For example, exergetic analysis was performed on this model for the air split-conditioner with the nominal cooling capacity 2500 W of „Mitsubishi Electric” firm under standard external temperature conditions and received the output-input exergetic ratio (OIER) and exergetic losses in the air split-conditioner individual elements on the refrigerants R410A, R32 and refrigerant R290 (propane). It is shown that the the exergetic efficiency of the air split-conditioner increased by 9.3% and 5.1%, when using the R290 refrigerant compared to R410A and R32, respectively.
К ВОПРОСУ О НЕПРЕРЫВНОСТИ В ФИЗИКЕ
Authors: Прокопов Алексей
Published: June 2021

Цель работы в рассмотрении природы через объединение двух концепций: континуума и реляционности. В зависимости от того, что ставить вначале, мы: рассматриваем континуум с реляционной точки зрения, или дополняем реляционный взгляд на природу концепцией континуума.
The Scent of Russia on the Léman Shores
Authors: Kosenko S. M.
Published: June 2021

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«Partnership for Modernization» between Russia and EU
Authors: Entin M. L. , Istomin I. A.
Published: June 2021

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The Relations between Russia and Romania Since 1989 in the Context of their Foreign Policy Priorities
Authors: Kirillov V. B. , Putintsev I. S.
Published: June 2021

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The Conceptualization and Operationalization of the Concept of Statehood
Authors: Tokarev A. A.
Published: June 2021

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The Situation in the Arab World: An Analysis and Forecast
Authors: Podtserob A. B.
Published: June 2021

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«Peaceful Atom» – from the XXth to the XXI century: from the weapons of mass destruction to the driver of the massive progress
Authors: Zharkikh M. V.
Published: June 2021

The article is dedicated to the progress-analysis of the development of one of the most promising fields of economy and industry of Russia as well as many other states of the world – the atomic energy sector. Its evolution and competitive advantages before the other sources of energy supply are attended in brief. Special attention is devoted to international cooperation in the atomic energy field, incentivized at the beginning of the XXI century. Dynamics of this cooperation has shown that atomic energy can and, most probably, in the nearest future, will become one of the main factors of an advanced socioeconomic development of most of the states.
Institutional Tools of Innovative Modernization of Russian Megapolis Financial Market
Authors: Roshchektaev S. A. , Pogrebenko A. N.
Published: June 2021

The article is devoted to the justification of a new group of institutional instruments of innovative modernization of the financial market of the modern Russian megapolis – integrated network of development institutions. It is shown that these institutions are focused on the integration of the economic space of the megapolis and the rational structuring of the financial market.
Public-private partnership as a mechanism for sustainable development of the Sverdlovsk Oblast: A determinantal analysis
Authors: KUKLINOV Mikhail L. , YUGOV Vladimir V.
Published: June 2021

Subject. This article discusses the role of public-private partnership in solving the priorities of the socio-economic development of the regions.
Objectives. The article aims to identify institutional factors in public-private partnership development.
Methods. For the study, we used the methods of statistical analysis.
Results. Regarding the Ural Federal District subjects as a case study, the article examines the dynamics of public-private partnership projects development over the past decade. It considers the forms of institutional corruption and proposes certain mechanisms to overcome it.
Conclusions. Analyzing key internal and external factors influencing the development of the public-private partnership system directly or indirectly will help enhance opportunities and capabilities when implementing economic projects.
Phylogenetic tree analysis based on the 16S sequence alignment for Klebsiella spp. isolated from different sources
Authors: Ibrahim Israa AJ. , Kareem Tuqa A. , Azeez Yaseen M. , Falhi Hawraa K.
Published: June 2021

16S ribosomal RNA (16S rRNA) gene sequences used to study bacterial phylogeny and taxonomy have been by far the most common housekeeping genetic marker utilized for identification and ancestor determination. This study aimed to investigate, for the first time, the relationship between Klebsiella spp. isolated from clinical and environmental samples in Iraq.

Fifty Klebsiella spp. isolates were isolated from clinical and environmental sources. Twenty-five isolates were collected from a fresh vegetable (Apium graveolens) and 25 from clinical samples (sputum, wound swab, urine). Enteric bacteria were isolated on selective and differential media and identified by an automatic identification system, vitek-2. The total DNA was extracted and PCR amplified for selected isolates. The 16S rRNA gene was amplified by using the universal primer 27F (5'- AGAGTTTGATCCTGGCTCAG- 3') and 1492R (5'- GGTTACCTTGTTACGACTT- 3â€™). The 16SrRNA gene sequence was analysed among some local isolates, and the results were compared with the standard data of similar registered strains in NCBI. The most common species of Klebsiella was Klebsiella pneumoniae pneumoniae (Kpp), followed by Klebsiella pneumoniae ozaenae (Kpo) and Klebsiella oxytoca (Ko). The results of the identification of species and sub species by using the  biochemical test (vitek-2) were more precise than those obtained by the use of the universal primer.Phylogenetic tree strategies have clearly indicated a relatively close similarity amongst all analysed Klebsiella isolates and revealed the intra-species genetic distance between the individual isolates of the Klebsiella spp. In conclusion, our results revealed the main advantage of using universal primers for the identification of Klebsiella spp. and their root from nature.
Teaching mathematics with mobile devices and the Realistic Mathematical Education (RME) approach in kindergarten
Authors:   Department of Preschool Education, Faculty of Education, University of Crete, Crete, Greece, Papadakis Stamatios , Kalogiannakis Michail ,   Faculty of Education & Department of Preschool Education, The University of Crete, Greece, Zaranis Nicholas ,   Faculty of Education & Department of Preschool Education, The University of Crete, Greece
Published: June 2021

Nowadays, smart mobile devices such as tablets and accompanying applications (apps) are a part of young children's daily lives. In kindergarten education, properly designed digital educational activities can become a potent educational tool for efficient and effective learning. These tools allow children to take advantage of new learning platforms and effectively reach new knowledge through activities related to their immediate interests and real-life scenarios in learning domains, such as mathematics. At the Department of Preschool Education, University of Crete, systematic research was carried out in the last years to investigate whether there are compelling benefits to using tablet-type devices in preschool education to implement teaching reform proposals to implement the Realistic Mathematical Education in kindergarten classrooms. The findings propose mobile devices' integration, running developmentally appropriate apps, in kindergarten classrooms. These apps were based on the three levels of Realistic Mathematics Education (RME), targeting fundamental mathematical concepts for the kindergarten level.
Reinforcing preschoolers’ phonemic awareness through the use of tablets
Authors:   Faculty of Education & Department of Preschool Education, The University of Crete, Greece, Skaraki Evaggelia
Published: June 2021

This study aimed to implement an intervention program to examine whether tablets enhance kindergarten children’s phonemic awareness. Seventy-four (74) kindergarten children (40 boys and 34 girls) aged 4 to 6 years from 4 public kindergarten classrooms participated in the study, from which 38 children formed the experimental group while 36 children formed the control one. During the intervention program, children in the experimental group were trained through tablets in initial phoneme identification, initial phoneme deletion, and phoneme segmentation, while the control group trained in the same tasks without tablets. Results showed statistically significant differences in favor of the experimental group. In conclusion, the present research found that digital media help educational practice, but it is also how teachers use digital tools to facilitate learning.
Telaahan Literatur Tentang Program Perawatan Pesawat Udara
Authors: Mora Minda
Published: June 2021

Maintenance is one of the most important thing in aviation. Maintenance is the process where a systems designed-in level of failure resistance is restored to or as close as economic viable to the most adequate level of the design. In order to conduct maintenance in the right way, each aircraft is required to have a Maintenance Program (MP). There are three main actors relating to the initial development of the MP, which are the manufacturer, the Industrial Steering Committee (ISC) and the Maintenance Review Board (MRB). In the manufacturers, PPH (Policies and Procedures Handbook) process for developing the initial MP is clearly described. The PPH is prepared by the manufacturer and presented to the ISC (Industrial steering committee) for review and approval. ISC then forwards it to the MRB chairpersons and other regulatory authorities for acceptance.Based on MRB review, the manufacturer develop Maintenance Review Board Report (MRBR) and Maintenance Planning Document (MPD). When introducing a new fleet of aircraft into the operator, there is no experience and the organization must follow the MRBR (Maintenance Review Board Report) and MPD (Maintenance Planning Document) when setting up their own MP. It is the operator’s responsibility to ensure that their MP is up to date. When a new revision of the MRBR and MPD is released the operator should incorporate the alterations into their MP and update their maintenance system and make the revision active at next suitable opportunity. The next suitable opportunity would be before next major base input or c-check.Perawatan pesawat udara merupakan salah satu unsur penting dalam penerbangan. Perawatan adalah semua kegiatan yang dilakukan untuk mempertahankan pesawat udara, komponen-komponen pesawat udara dan perlengkapannya dalam keadaan laik udara termasuk inspeksi, reparasi, servis, overhaul dan penggantian part. Untuk dapat melakukan perawatan dengan benar, maka setiap pesawat udara diharuskan memiliki Program Perawatan. terdapat 3 (tiga) pihak yang terlibat dalam penyusunan awal Program Perawatan, yaitu pabrikan pesawat udara, the Maintenance Review Board (MRB), dan the Industrial Steering Committee (ISC). Pabrikan berkewajiban membuat Policy and Procedures Handbook (PPH) yang berisi informasi lengkap dan jelas tentang proses penyusunan Program Perawatan Pesawat Awal. PPH kemudian diserahkan kepada ISC yang berkewenang untuk melakukan peninjauan terhadap PPH dan apabila telah memenuhi persyaratan maka ISC mengeluarkan persetujuan terhadap PPH (approval). Selanjutnya, ISC menyerahkan PPH kepada MRB untuk evaluasi dan analisis lebih lanjut. Berdasarkan evaluasi dan analisis MRB, pabrikan membuat Maintenance Review Board Report (MRBR) dan Maintenance Planning Document (MPD). MRBR dan MPD merupakan panduan bagi operator pesawat udara untuk melakukan perawatan pesawat udara dan membuat Program Perawatan pesawat udara sendiri. Namun, operator berkewajiban untuk memperbahatui Program Perawatannya apabila terdapat perubahan MRBR dan MPD dari pabrikan.