bluuebunny/crossref_metadata_2025 huggingface dataset:
GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo
Authors: Healy Jane A. , Nugent Adrienne , Rempel Rachel E. , Moffitt Andrea B. , Davis Nicholas S. , Jiang Xiaoyu , Shingleton Jennifer R. , Zhang Jenny , Love Cassandra , Datta Jyotishka , McKinney Matthew E. , Tzeng Tiffany J. , Wettschureck Nina , Offermanns Stefan , Walzer Katelyn A. , Chi Jen-Tsan , Rasheed Suhail A. K. , Casey Patrick J. , Lossos Izidore S. , Dave Sandeep S.
Published: March 2016

Key Points

In mice, loss of GNA13 in GC B cells protects against cell death and may promote genetic instability via ongoing somatic hypermutation. Gna13 loss, in combination with MYC overexpression, promotes lymphoma in mice.
Behavioural and psychological symptoms in dementia and the
challenges for family carers: Systematic review
Authors: Feast Alexandra , Orrell Martin , Charlesworth Georgina , Melunsky Nina , Poland Fiona , Moniz-Cook Esme
Published: March 2016

Background

Tailored psychosocial interventions can help families to manage
behavioural and psychological symptoms in dementia (BPSD), but carer
responses to their relative's behaviours contribute to the success of
support programmes.

Aims

To understand why some family carers have difficulty in dealing with
BPSD, in order to improve the quality of personalised care that is
offered.

Method

A systematic review and meta-ethnographic synthesis was conducted of
high-quality quantitative and qualitative studies between 1980 and
2012.

Results

We identified 25 high-quality studies and two main reasons for behaviours
being reported as challenging by family carers: changes in communication
and relationships, resulting in ‘feeling bereft’; and perceptions of
transgressions against social norms associated with ‘misunderstandings
about behaviour’ in the relative with dementia. The underlying belief
that their relative had lost, or would inevitably lose, their identity to
dementia was a fundamental reason why family carers experienced behaviour
as challenging.

Conclusions

Family carers' perceptions of BPSD as challenging are associated with a
sense of a declining relationship, transgressions against social norms
and underlying beliefs that people with dementia inevitably lose their
‘personhood’. Interventions for the management of challenging behaviour
in family settings should acknowledge unmet psychological need in family
carers.
Cheaper Options in the Prevention of Chemotherapy-Induced Nausea and Vomiting
Authors: Gyawali Bishal , Poudyal Bishesh Sharma , Iddawela Mahesh
Published: March 2016

Chemotherapy-induced nausea and vomiting (CINV) is a common challenge in oncology practice for which there are expensive guideline-based treatment options. Although supportive care in cancer adds significantly to the overall cost, the discussion of unaffordability of anticancer treatment frequently only revolves around the targeted drugs and immunotherapies. In this review, we highlight the available cost-saving strategies and recent updates in preventing CINV in patients with cancer. This is the first work, to our knowledge, to review specifically the less expensive alternatives in CINV prevention, which is particularly important for those working in resource-limited settings. Whereas patients in these settings often cannot afford expensive antiemetics, we now have the science to offer cheaper, more affordable options without necessarily compromising efficacy.
TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus
Authors: Sai Kazuhito , Morioka Sho , Takaesu Giichi , Muthusamy Nagendran , Ghashghaei H. Troy , Hanafusa Hiroshi , Matsumoto Kunihiro , Ninomiya-Tsuji Jun
Published: March 2016

Sustained endoplasmic reticulum (ER) stress disrupts normal cellular homeostasis and leads to the development of many types of human diseases, including metabolic disorders. TAK1 (also known as MAP3K7) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family and is activated by a diverse set of inflammatory stimuli. Here, we demonstrate that TAK1 regulates ER stress and metabolic signaling through modulation of lipid biogenesis. We found that deletion of Tak1 increased ER volume and facilitated ER-stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory-element-binding protein (SREBP)-dependent lipogenesis. In the in vivo setting, central nervous system (CNS)-specific Tak1 deletion upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. Furthermore, CNS-specific Tak1 deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions.
Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels
Authors: Valente Pierluigi , Lignani Gabriele , Medrihan Lucian , Bosco Federica , Contestabile Andrea , Lippiello Pellegrino , Ferrea Enrico , Schachner Melitta , Benfenati Fabio , Giovedì Silvia , Baldelli Pietro
Published: March 2016

L1 (also known as L1CAM) is a trans-membrane glycoprotein mediating neuron–neuron adhesion through homophilic and heterophilic interactions. Although experimental evidence has implicated L1 in axonal outgrowth, fasciculation and pathfinding, its contribution to voltage-gated Na+ channel function and membrane excitability has remained unknown. Here, we show that firing rate, single cell spiking frequency and Na+ current density are all reduced in hippocampal excitatory neurons from L1-deficient mice both in culture and in slices owing to an overall reduced membrane expression of Na+ channels. Remarkably, normal firing activity was restored when L1 was reintroduced into L1-deficient excitatory neurons, indicating that abnormal firing patterns are not related to developmental abnormalities, but are a direct consequence of L1 deletion. Moreover, L1 deficiency leads to impairment of action potential initiation, most likely due to the loss of the interaction of L1 with ankyrin G that produces the delocalization of Na+ channels at the axonal initial segment. We conclude that L1 contributes to functional expression and localization of Na+ channels to the neuronal plasma membrane, ensuring correct initiation of action potential and normal firing activity.
A Theoretical Study on the Mechanism and Kinetics of the Reaction of Methylthiyl Radical with Ozone
Authors: Mousavipour Seyed Hosein , Sadeghi Mojgan
Published: March 2016

Reaction mechanism and kinetics of gas-phase reaction of methylthiyl radical (CH3S (2A′)) with ozone (1A1) on the lowest doublet electronic state has been theoretically investigated. The composite method of G3MP2 was employed to obtain the optimized geometries of the stationary points and their energies. The most probable path for the title reaction is a barrier-less association channel to form a chemically activated intermediate of CH3SOOO*. The major products at lower temperatures are CH3SO and O2 while species like, CH3, SO, SO2, CH2S, CH2SOH, CH2SO, HO2, and OH are among the products of the probable secondary reactions. Direct hydrogen abstraction reaction of O3 with CH3S to form CH2S and HO3 is not an important channel at lower temperatures. Multichannel RRKM calculations along with the steady-state assumption for the energized intermediate and canonical variational transition-state theory have been used to predict the rate constants for the formation of the most important products. Rate constants for dissociation and isomerization of vibrationally “hot” CH3SO to form CH3 + SO and CH2SOH, respectively, are calculated by means of RRKM method, which are compared with those calculated for the vibrationally “cold” CH3SO. To comply with the previous experimental observations, the major product of the title reaction (CH3SO) should be produced as vibrationally “hot”.
Safer sleep and preventable deaths
Authors: Fisher Maggie
Published: March 2016

Safer Sleep Week from 14–20 March is a timely reminder of the important role that health visitors and their teams can play in reducing infant mortality, says Maggie Fisher.
The use of common medications during breastfeeding
Authors: Shah Chetan , Devit Reena , Wong Madeline
Published: March 2016

Health visitors have a pivotal role in promoting, supporting and monitoring breastfeeding, and should be aware of the benefits and risks associated with prescribed medication during breastfeeding. Taking medication does not usually mean that a mother has to stop breastfeeding and the list of drugs that are unsafe for breastfeeding mothers is small. This article discusses the use of common medications while breastfeeding, including their drug safety profile, the effect of the drug on the infant and whether there is any monitoring that the health visitor could undertake. Health visitors should encourage mothers to continue breastfeeding if it is safe to do so and can seek expert advice from their local medicines information pharmacist around the use of medication in lactation.
Crossing the language barrier to provide culturally sensitive care
Authors: Costa Beverley
Published: March 2016

Mothertongue provides professional counselling to people from black and ethnic minority backgrounds in their preferred language. Beverley Costa explains how health visitors can work with multilingual families to ensure culturally sensitive care.
Five levels of leadership
Authors: Oldman Crystal
Published: March 2016

An issue that is critical to success in navigating and implementing change is leadership. The health visiting service knows this, perhaps more than any other part of the NHS at the moment, says Crystal Oldman.
Singing and doing
Authors: Hewson Claire
Published: March 2016

Emma Atack's book and CD of singalong songs include themes such as animals at the zoo and going to the shops, which can inspire children to create imaginative scenarios using small world play.
Find time for rhyme
Authors: Harries Judith
Published: March 2016

Explore a variety of rhyming activities and discover how playing with rhymes helps children to have fun using language as they talk, read, write, sing and play! Create a rhyme zone area to link with ICT.
Aortic bypass surgery using synthetic conduits in a child with mycotic aneurysmal disease
Authors: Sayed A , Mashaal M , Soliman SA , Elwan H
Published: March 2016

A six-year-old child developed multiple aortic aneurysms as a consequence of fungal infection following thoracic aortic surgery for coarctation. Several repairs of both the thoracic and abdominal aorta were carried out using synthetic material combined with long-term postoperative antifungal treatment. We describe the surgical interventions performed and follow-up. The choice of conduit continues to be the main concern; however, when other alternatives are not available, synthetic material combined with indefinite antifungal treatment can produce satisfactory medium-term results.
Perineal herniation of an ileal neobladder following radical cystectomy and consecutive rectal resection for recurrent bladder carcinoma
Authors: Neumann PA , Mehdorn AS , Puehse G , Senninger N , Rijcken E
Published: March 2016

Secondary perineal herniation of intraperitoneal contents represents a rare complication following procedures such as abdominoperineal rectal resection or cystectomy. We present a case of a perineal hernia formation with prolapse of an ileum neobladder following radical cystectomy and rectal resection for recurrent bladder cancer. Following consecutive resections in the anterior and posterior compartment of the lesser pelvis, the patient developed problems emptying his neobladder. Clinical examination and computed tomography revealed perineal herniation of his neobladder through the pelvic floor. Through a perineal approach, the hernial sac could be repositioned, and via a combination of absorbable and non-absorbable synthetic mesh grafts, the pelvic floor was stabilised. Follow-up review at one year after hernia fixation showed no signs of recurrence and no symptoms.

In cases of extensive surgery in the lesser pelvis with associated weakness of the pelvic compartments, meshes should be considered for closure of the pelvic floor. Development of biological meshes with reduced risk of infection might be an interesting treatment option in these cases.
El empleo en las cooperativas de trabajo asociado: ¿derecho al trabajo o factor productivo?
Authors: Bengoetxea Alkorta Aitor
Published: March 2016

Las sociedades capitalistas y las sociedades cooperativas muestran una naturaleza distinta. Las primeras giran en torno al capital que les da vida, y las segundas son personalistas; las personas cooperativistas tienen primacía con respecto al capital que aportan.

La diferencia es evidente en el ámbito de las decisiones empresariales. En las sociedades capitalistas, los votos se distribuyen en proporción al capital aportado. En las cooperativas, impera el clásico principio de una persona, un voto.

Las situaciones de crisis afectan por igual a ambos tipos de empresa. Sin embargo, la respuesta, con respecto al empleo, es diferente. En las sociedades de capital, el Derecho del Trabajo ofrece una variada gama de medidas para afrontar las situaciones de crisis, algunas de flexibilidad interna (movilidad funcional, reducción de jornada, suspensión contractual, etc.), y también el despido, una más de las posibilidades de la empresa.

En las cooperativas, el Derecho Cooperativo deja claro que la baja obligatoria de las personas socias-trabajadoras (equivalente al despido), solo procederá como última ratio, cuando las medidas de flexibilidad interna se muestren insuficientes y sea necesario para garantizar la viabilidad futura de la empresa.

Al tratar el despido como una medida supeditada a la obtención de beneficios, el Derecho del Trabajo trata el empleo como un mero factor productivo. El Derecho Cooperativo, sin embargo, al considerar la pérdida de empleo como último recurso, está preservando su carácter de derecho social.
La participación de las mujeres en las spin-offs universitarias
Authors: Pastor Inma , Pontón Paloma , Acosta Ana , Belzunegui Ángel , Aguado Empar , Poveda María , Blanco Ana Isabel , Rodríguez Adelina
Published: March 2016

El presente trabajo pretende abordar el fenómeno del emprendimiento desde la perspectiva de género y, de manera más concreta, analizar la cuestión de la escasa participación laboral de las mujeres en las spin-off universitarias. La ponencia pretende dar a conocer algunos de los resultados de investigación del proyecto en curso EQUASPIN: La participación laboral de las mujeres. El caso de las spin-offs universitarias. Este proyecto ha tenido como objetivo abordar los efectos de la división sexual del trabajo sobre la creación de las spin-offs universitarias. De esta manera, se ha tratado de verificar si las diferencias encontradas en la creación de empleo por cuenta propia según el género también se manifiesta en la creación de spin-offs y a la vez de observar el papel que juega el propio sistema universitario en la producción y reproducción de las desigualdades de género. En esta comunicación se presentan los resultados obtenidos tras llevar a cabo el análisis de un buen número de entrevistas realizadas a personas emprendedoras, directores y directoras de grupos de investigación, así como los resultados de una encuesta a una muestra de 52 spin-offs. El trabajo de campo se ha realizado en las universidades de cuatro comunidades autónomas. El ámbito geográfico seleccionado es intercomunitario y corresponde a las comunidades autónomas de Cataluña, Comunidad Valenciana, Castilla-León y Madrid. Tras el análisis de los discursos realizados se ha concluido con la identificación de cinco tipologías principales de los mismos que van desde la negación hasta posturas críticas respecto a las desigualdades de género.
Negociaciones de pareja: los trabajos domésticos, la crianza y la construcción de la maternidad y la paternidad
Authors: Agirre Amaia
Published: March 2016

En este artículo se presentan algunas de las conclusiones de una investigación llevada a cabo con parejas que se definen a sí mismas como paritarias. Desde una perspectiva de género se analizan las negociaciones que se dan en este tipo de relaciones igualitarias. Así, se ha podido comprobar cómo los trabajos domésticos y de crianza son dos de las cuestiones que más se negocian, aunque dichas negociaciones no suelen ser explícitas ni sistemáticas, ya que se viven de manera conflictiva al entrar en contradicción con el ideal de amor romántico imperante en nuestra sociedad, que plantea la relación de pareja como una unidad en la que los intereses confluyen. De la misma manera, se ha comprobado la importancia que la construcción cultural de la maternidad y la paternidad tiene en la creación de la identidad de género y, en consecuencia, en la visión y tiempo dedicado a los trabajos de crianza.
Cuidados "en cadena": cuerpos, emociones y ética en las residencias de personas mayores
Authors: Moré Corral Paloma
Published: March 2016

Este artículo explora la realidad del trabajo de cuidados de larga duración en residencias para personas mayores. El objetivo es analizar los efectos que tiene la organización social del trabajo de cuidados, tanto a nivel social como en los propios centros, sobre quienes lo realizan —en su gran mayoría mujeres que se encuentran en la intersección de desigualdades de género, clase social, etnicidad y/o estatus migratorio—. La metodología utilizada es cualitativa e incluye entrevistas en profundidad a trabajadores de distintos centros, personal directivo de centros y personal técnico servicios públicos y observación participante acompañando al personal de dos centros (uno en Madrid y otro en París) durante sus jornadas laborales. A partir de situaciones concretas de trabajo se problematiza la idea que relaciona los cuidados con el universo inmaterial (afectos, emociones, amor) y se pone de manifiesto, por un lado, que las emociones no pueden desvincularse de la materialidad que las produce; y por otro lado, que el contexto concreto es fundamental para comprender los puntos de vista éticos (buen/mal cuidado) en relación al trabajo de cuidados.
La "triple presencia-ausencia": una propuesta para el estudio del trabajo doméstico-familiar, el trabajo remunerado y la participación sociopolítica
Authors: Sagastizabal Marina , Legarreta Matxalen
Published: March 2016

El artículo tiene como objetivo ofrecer una reflexión sobre la “triple presencia-ausencia”, una propuesta para el estudio de los cuidados que parte de una mirada amplia, abordando su relación con el trabajo remunerado y con la participación sociopolítica. La propuesta se sitúa en los debates desarrollados en las últimas décadas en torno a los cuidados, principalmente en relación a tres líneas de trabajo centradas respectivamente en: la dimensión material del trabajo doméstico-familiar, el aprendizaje de género y la ética del cuidado. La potencialidad de la noción la “triple presencia-ausencia” descansa en su capacidad para complejizar el análisis de los cuidados en dos sentidos. Por un lado, relaciona los cuidados no sólo con el trabajo remunerado (como lo hacen planteamientos predecesores en torno a la “doble jornada” o la “doble presencia-ausencia”), sino también con la participación sociopolítica. Por otro lado, presta atención tanto a la materialidad (ocupaciones en sentido estricto) como a los aspectos subjetivos y morales del trabajo doméstico-familiar (responsabilidad, disponibilidad, preocupación…). Es una propuesta de corte eminentemente analítico que deberá ser contrastada a nivel empírico en futuros trabajos.
Subjetividad y materialidad del cuidado: ética, trabajo y proyecto político
Authors: Molinier Pascale , Legarreta Matxalen
Published: March 2016

Introducción al monográfico sobre Subjetividad y materialidad del cuidado: ética, trabajo y proyecto político
The Role of Landscape Architecture Profession In Two Different Contexts: A Comparative Review of the Practitioners in Responding To Climate Change Adaptation
Authors: Mildawani Irina , Khan Shahed
Published: March 2016

In the context of rising concerns about global warming and sustainable development this paper examines the challenges of landscape architecture (LA) in developing and developed countries in handling climate change adaptation. The paper aims to find how the LA institutes define their professionals’ roles in dealing with society and environment. It seeks to focus on the professionals’ involvement in climate change adaptation programs in Indonesia and Australia. The paper seeks to determine how contextual factors such as institutional roles and types of prevalent governance systems shape the development of landscape architecture discipline and its professional capability with respect to other related built environment professions (architecture and planning). The websites of the ISLA (Indonesian Society of Landscape Architects) and the AILA (Australian Institutes of Landscape Architects) are examined and analysed from the perspective of professional principles of the International Federation of Landscape Architects (IFLA). The aim is to determine the LA practitioners’ awareness and approaches in handling climate change challenges in various roles and capabilities. It has found that the professional institute in Australia has been involved in the educational program to equip their practitioner members to have a basic knowledge and further application of climate change adaptation in their design and planning projects; whereas in Indonesia the practitioners are actively involved in community capacity building to increase people’s awareness and participation in mitigating the climate change at local as well as regional levels. Findings from the study seek to establish the universality of the LA profession and its relevance in both developed and developing countries.
Klasifikasi Tipologi Zona Perwilayahan Wilayah Peri-Urban di Kecamatan Kartasura, Kabupaten Sukoharjo
Authors: Kurnaianingsih Nela Agustin
Published: March 2016

Wilayah Peri-Urban yang hadir sebagai zona transisi antara kota dan desa telah memberikan ragam wilayah baru yang memiliki karakteristik yang unik. Keunikan perkembangan yang membuat WPU memiliki sifat kekotaan dengan kepadatan yang tinggi dan aktivitas yang beraneka ragam dan ramai, dan juga keunikan sifat pedesaan yang tetap hadir dengan bercirikan sektor pertanian. Sifat kekotaan dan pedesaan yang dimiliki WPU timbul sebagai dampak perkembangan kota di sekitarnya. Kecamatan Kartasura merupakan salah satu anggota Wilayah Peri-Urban yang muncul sebagai bentuk nyata dampak perkembangan Kota Surakarta dalam aspek fisik, sosial, dan ekonomi. Kemampuan Kota Surakarta yang mampu mempengaruhi perkembangan Kecamatan Kartasura ternyata dapat memunculkan sifat kekotaan di sebagian wilayah desa. Di samping itu, perkembangan Kecamatan Kartasura juga disinyalir berkat historis yang tinggi sebagai salah satu pusat kerajaan Islam di Jawa Tengah dan menjadi cikal bakal Surakarta. Namun dengan perkembangan yang tidak merata, menimbulkan adanya fenomena keeksistensian sifat pedesaan sebagai karakteristik unik WPU. Untuk secara nyatanya, diketahui bahwa, meskipun terjadi alih fungsi lahan pertanian tiap tahunnya sebagai bentuk perkembangan kekotaan, sektor pertanian Kecamatan Kartasura masih tetap bertahan dengan dibuktikan melalui peningkatan PDRB di sektor ini. Keunikan sifat kekotaan yang berpadu dengan sifat pedesaan di WPU Kecamatan Kartasura ini menimbulkan suatu pertanyaan, “bagaimana klasifikasi zona perwilayah yang terbentuk di Wilayah Peri-Urban tersebut, tentu saja jika dilihat dari aspek fisik, sosial, dan ekonomi?” Melalui pertanyaan tersebut, penelitian ini dibuat untuk melakukan identifikasi tingkat urbanisasi suatu desa dalam aspek fisik, sosial dan ekonomi yang ditujukkan dalam zona perwilayah WPU, meliputi zona peri-urban primer, zona peri-urban sekunder, dan zona rural peri-urban. Klasifikasi zona perwilayahan dengan analisis spasial yang memanfaatkan SIG ini mendapatkan hasil berupa tiga zona yang terdiri dari: peri-urban primer meliputi 2 desa/kelurahan dengan luas wilayah sebesar 265 Ha, peri-urban sekunder meliputi 8 desa dengan luas wilayah 1.368 Ha, dan rural peri-urban yang meliputi 2 desa dengan luas wilayah sebesar 290 Ha. Dari hasil klasifikasi ini sendiri ditemukan karakteristik WPU yang menjadi ciri khas Kecamatan Kartasura yang membedakan dengan wilayah peri-urban lainnya.
The Chinese Sufi Wiqāyatullāh Ma Mingxin and the Construction of his Sanctity in Kitāb al-Jahrī
Authors: Sobieroj Florian
Published: March 2016

By contrast to the majority of the Muslim authors of Chinese origin who composed their literary works in the Chinese language, the authors of the Jahriyya Sufi order, a still active branch of the Naqshbandiyya network rooted mainly in the provinces of Gansu and Ningxia, have produced a small number of texts in the Arabic language and through this means they have recorded the conflict-ridden history of their menhuan and left behind a description of their belief-system. The main focus in this article lies on the sanctity (wilāya) of Ma Mingxin Wiqāyatullāh (died 1781), founder (daozu 道祖) of the Jahriyya order, as remembered and construed by his hagiographers in general and by the author of the Kitāb al-Jahrī, Manṣūr Ma Xuezhi (end of 19th and beginning of 20th c.), in particular: in their construction, Mingxin’s sanctity manifests itself in miracles, predictions, exorcisms and spiritual states. The text of the K. al-Jahrī which is the most comprehensive of the hagiographical writings of the Jahriyya as well as the other works of this group (e. g. Manāqib; Rashaḥāt) have all been transmitted in manuscript form within the Sufi order, they have been published in facsimile and been partly translated into Chinese. Hence a second focus has been laid on the codicology of the manuscript of the K. al-Jahrī, the basis of this study. Although the article mainly takes a codicological, philological and phenomenological approach to the subject of Mingxin´s sanctity, the historical background to his career as portrayed in the Chinese and Western-language studies has also been taken into consideration.
Numerical assessment of the reduction of specific absorption rate by adding high dielectric materials for fetus MRI at 3 T
Authors: Luo Minmin , Hu Can , Zhuang Yayun , Chen Wufan , Liu Feng , Xin Sherman Xuegang
Published: March 2016

The specific absorption rate (SAR) is an important issue to be considered in fetus MRI at 3 T due to the high radiofrequency energy deposited inside the body of pregnant woman. The high dielectric material (HDM) has shown its potential for enhancing B1 field and reducing SAR in MRI. The aim of this study is to assess the feasibility of SAR reduction by adding an HDM to the fetus MRI. The feasibility of SAR reduction is numerically assessed in this study, using a birdcage coil in transmission loaded with an electromagnetic pregnant woman model in the SEMCAD-EM solver. The HDMs with different geometric arrangements and dielectric constants are manually optimized. The

${B_1}^ + $
homogeneity is also considered while calculating the optimized fetus 10 g local SAR among different strategies in the application of HDM. The optimum maximum fetus 10 g local SAR was obtained as 2.25 W/kg, by using two conformal pads placed left and right with the dielectric constant to be 400, reduced by 24.75% compared to that without the HDM. It indicated that the SAR can be significantly reduced with strategic placement of the HDM and the use of HDM may provide a simple, effective and low-cost method for reducing the SAR for the fetus MRI at 3 T.
Molecular diagnosis and precision medicine in allergy management
Authors: Riccio Anna Maria , De Ferrari Laura , Chiappori Alessandra , Ledda Sabina , Passalacqua Giovanni , Melioli Giovanni , Canonica Giorgio Walter
Published: March 2016

Precision medicine (PM) can be defined as a structural model aimed at customizing healthcare, with medical decisions/products tailored on an individual patient at a highly detailed level. In this sense, allergy diagnostics based on molecular allergen components allows to accurately define the patient’s IgE repertoire. The availability of highly specialized singleplexed and multiplexed platforms support allergists with an advanced diagnostic armamentarium. The therapeutic intervention, driven by the standard diagnostic approach, but further supported by these innovative tools may result, for instance, in a more appropriate prescription of allergen immunotherapy (AIT). Also, the phenotyping of patients, which may have relevant effects on the treatment strategy, could be take advantage by the molecular allergy diagnosis.
Multiple-Instance Learning via an RBF Kernel-Based Extreme Learning Machine
Authors: Wang Jie , Cai Liangjian , Zhao Xin
Published: March 2016

As we are usually confronted with a large instance space for real-word data sets, it is significant to develop a useful and efficient multiple-instance learning (MIL) algorithm. MIL, where training data are prepared in the form of labeled bags rather than labeled instances, is a variant of supervised learning. This paper presents a novel MIL algorithm for an extreme learning machine called MI-ELM. A radial basis kernel extreme learning machine is adapted to approach the MIL problem using Hausdorff distance to measure the distance between the bags. The clusters in the hidden layer are composed of bags that are randomly generated. Because we do not need to tune the parameters for the hidden layer, MI-ELM can learn very fast. The experimental results on classifications and multiple-instance regression data sets demonstrate that the MI-ELM is useful and efficient as compared to the state-of-the-art algorithms.
The NKG2008 GPS campaign – final
transformation results and a new common Nordic
reference frame
Authors: Häkli P. , Lidberg M. , Jivall L. , Nørbech T. , Tangen O. , Weber M. , Pihlak P. , Aleksejenko I. , Paršeliunas E.
Published: March 2016

The NKG 2008 GPS campaign was carried out
in September 28 – October 4, 2008. The purpose was
to establish a common reference frame in the Nordic-
Baltic-Arctic region, and to improve and update the transformations
from the latest global ITRF reference frame
to the national ETRS89 realizations of the Nordic/Baltic
countries. Postglacial rebound in the Fennoscandian area
causes intraplate deformations up to about 10 mm/yr to
the Eurasian tectonic plate which need to be taken into account
in order to reach centimetre level accuracies in the
transformations.

We discuss some possible alternatives and present the
most applicable transformation strategy. The selected
transformation utilizes the de facto transformation recommended
by the EUREF but includes additional intraplate
corrections and a new common Nordic-Baltic reference
frame to serve the requirements of the Nordic/Baltic countries.
To correct for the intraplate deformations in the
Nordic-Baltic areawe have used the commonNordic deformation
model NKG RF03vel. The new common reference
frame, NKG ETRF00, was aligned to ETRF2000 at epoch
2000.0 in order to be close to the national ETRS89 realizations
and to coincide with the land uplift epoch of the national
height systems. We present here the realization of
the NKG ETRF00 and transformation formulae together
with the parameters to transform from global ITRF coordinates
to Nordic/Baltic realizations of the ETRS89.
Congenital diaphragmatic hernia – a Belgrade single center experience
Authors: Kalanj Jasna , Salevic Petar , Rsovac Snezana , Medjo Biljana , Antunovic Sanja Sindjic , Simic Dusica
Published: March 2016

Objective:

Though the outcome for children with congenital diaphragmal hernia (CDH) is improving, management of seriously compromised respiratory and cardiovascular function remains a great challenge. The aim of this study was to review a tertiary center experience in treating children with CDH.

Design:

Retrospective observational study from January 2005 to December 2014.

Setting:

Neonatal Intensive Care Unit (NICU) of University Children Hospital (UCH), Belgrade, Serbia.

Patients:

Children with CDH.

Results:

The CDH was diagnosed prenatally in 23% patients. An overall survival rate was 62%. Among those patients who underwent surgical repair 29 (90%) survived. There was statistically significant difference in survival rate between operated patients and total examined population (P=0.020). Prenatally diagnosed neonates with CDH had significantly lower survival rate comparing to those who were postnatally diagnosed (20% vs. 75%; P=0.002). Fatal outcome was more frequent in patients with small birth weight comparing to those with normal birth weight (67% vs. 30%; P=0.046).

Conclusions:

Our center survival rate for CDH is in accordance with other reported studies. Based on our experience there are potential points for further improvement. First, further increase of prenatal detection, planning for delivery, and coordinated transfer to tertiary institution, in order to avoid transfer of near death patients. Second, preoperative management in the NICU. This could be done by more uniform implementation of current consensual guidelines in monitoring, mechanical ventilation and circulatory support of these delicate patients, together with rationale use of newer therapeutic resources.
Crystal structure of catena-[aqua((4-carboxyphenyl)acetato-κO)(μ2-(4-carboxyphenyl)acetato-κ2
O:O′)bis(4,4′-ethene-1,2-diyldipyridine-κN)manganese(II)], C42H36N4O9Mn
Authors: Wei-Dong Yin , Gui-Lian Li
Published: March 2016

C42H36MnN4O9, monoclinic, P21/c (no. 14), a = 9.6432(10) Å, b = 8.8336(10) Å, c = 42.379(5) Å, β = 92.053(1)°, V = 3607.7(7) Å3, Z = 4, R
gt
(F) = 0.0434, wR
ref
(F
2
) = 0.0910, T = 296(2) K.
Crystal structure of 2-benzylisothiouronium tetraphenylborate, C32H31BN2S
Authors: Mostafa Gamal A. E. , Ghabbour Hazem A. , Abdel-Aziz Hatem A.
Published: March 2016

C32H31BN2S, monoclinic, P21/c (no. 14), a = 8.7214(4) Å, b = 15.4388(7) Å, c = 20.1249(10) Å, β = 92.176(2)°, V = 2707.8 (2) Å3, Z = 4, R
gt
(F) = 0.0586, wR
ref
(F
2
) = 0.1588, T = 296 K.
Crystal structure of 3-(4-hydroxy-3-methoxyphenyl)-N-phenylpropanamide, C16H17NO3
Authors: Mierina Inese , Gudelis Emilis , Stepanovs Dmitrijs , Jure Mara , Mishnev Anatoly , Kolympadi Maria , Marković Dean
Published: March 2016

C16H17NO3, orthorhombic, P212121 (no. 19), a = 7.9882 (2) Å, b = 11.4053 (3) Å, c = 16.2381 (5) Å, V = 1479.42 (7) Å3, Z = 4, R
gt
(F) = 0.0480, wR
ref
(F
2
) = 0.0991, T = 173 K.
The Effect of a Complex (3-week) Therapy on the Hip and Knee Joints in Obese Patients
Authors: Tóvári Anett , Hermann Mária , Tóvári Ferenc , Prisztóka Gyöngyvér , Kránicz János
Published: March 2016

Currently, overweight and obesity are the most widespread problems in life-style having a significant impact on everyday life, and thus, conduct of life. Further contributory problems may develop in patients with weight problems: deformities of the joints and skeleton (coxarthrosis and gonarthrosis), circulatory problems and arrhythmia. Overweight definitely has an effect on motion: some people are not involved in certain activities as it is impossible for them because of their weight problem. Thus, even more health problems are generated because of the overweight. The first question arising in discussing the actuality of this issue is what effect the applied therapy (massage, therapeutic exercises, electrotherapy and balneotherapy) has on the knee and hip joints of patients with weight problems hospitalised in our Institute for a 3-week complex therapy. Based on my prior hypothesis, positive changes are detected in a minimum percentage in the condition of overweight or obese patients. My hypothesis was that the range of flexion and extension of the hip and knee joints would improve compared to other movements. Based on the results of the studied population (n=30), my hypothesis seems to be proven. After the 3-week complex therapy of obese patients, positive changes were found in the prearranged assessments and tests, thereby improving the general health, life-style, life quality and mental status of the patients. After the end of the complex therapy, patients were provided life-style counselling and exercise schemes to be performed in their home to maintain the achieved health status.
Crystal structure of the alluaudite Ag2Mn3(VO4)3
Authors: Yahia Hamdi Ben , Shikano Masahiro , Essehli Rachid , Belharouak Ilias
Published: March 2016

The new compound Ag2Mn3(VO4)3 was synthesized by hydrothermal and solid state reaction routes, and its crystal structure was determined from single-crystal X-ray diffraction data. Ag2Mn3(VO4)3 crystallizes with a monoclinic symmetry, space group C2/c, with a=11.8968(11) Å, b=13.2057(13) Å, c=6.8132(7) Å, β=111.3166(15) (°) and V=997.16(17) Å3 (Z=4). Its crystal refinement yielded the residual factors R(F)=0.0249 and wR(F
2)=0.0704 for 95 parameters and 1029 independent reflections at a 3σ(I) level. Ag2Mn3(VO4)3 can be considered as a new member of the AA′MM′2(XO4)3 alluaudite family. The specific arrangement of M and M′ octahedral sites and of X tetrahedral sites gives rise to two different channels aligned along the crystallographic c-axis and containing the A and A′ sites. The A, A′, M, and X sites are fully occupied by Ag+, Mn2+, and V5+, respectively; whereas a Mn2+/Mn3+ mixture is observed in the M′ site.
Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines
Authors: Erenler Ramazan , Pabuccu Koksal , Yaglioglu Ayse Sahin , Demirtas Ibrahim , Gul Fatih
Published: March 2016

In this study, the effect of Mougeotia nummuloides and Spirulina major on Vero cells (African green monkey kidney), C6 cells (rat brain tumor cells) and HeLa cells (human uterus carcinoma) was investigated in vitro. The antiproliferative effect of the methanol extract of M. nummuloides and S. major compared with 5-fluorourasil (5-FU) and cisplatin was tested at various concentrations using the BrdU Cell Proliferation ELISA. Both M. nummuloides and S. major extracts significantly inhibited the proliferation of Vero, HeLa and C6 cancer cell lines with IC50 and IC75 values. The M. nummuloides extract exhibited higher activity than 5-FU and cisplatin on Vero and C6 cells at high concentrations. The S. major extract revealed better antifproliferative activity than standards against Vero cells at 500 μg/mL. The compounds of methanol extracts were determined by GC-MS after the silylation process. Trehalose, monostearin and 1-monopalmitin were detected as major products in the M. nummuloides extract where as in the S. major extract; monostearin, 1-monopalmitin and hexyl alcohol were the main constituents.
Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes
Authors: Giauque Christopher C , Bickel Sharon E
Published: March 2016

Accurate segregation of homologous chromosomes during meiosis depends on their ability to remain physically connected throughout prophase I. For homologs that achieve a crossover, sister chromatid cohesion distal to the chiasma keeps them attached until anaphase I. However, in Drosophila melanogaster wild-type oocytes, chromosome 4 never recombines, and the X chromosome fails to cross over in 6–10% of oocytes. Proper segregation of these achiasmate homologs relies on their pericentric heterochromatin-mediated association, but the mechanism(s) underlying this attachment remains poorly understood. Using an inducible RNA interference (RNAi) strategy combined with fluorescence in situ hybridization (FISH) to monitor centromere proximal association of the achiasmate FM7a/X homolog pair, we asked whether specific heterochromatin-associated proteins are required for the association and proper segregation of achiasmate homologs in Drosophila oocytes. When we knock down HP1a, H3K9 methytransferases, or the HP1a binding partner Piwi during mid-prophase, we observe significant disruption of pericentric heterochromatin-mediated association of FM7a/X homologs. Furthermore, for both HP1a and Piwi knockdown oocytes, transgenic coexpression of the corresponding wild-type protein is able to rescue RNAi-induced defects, but expression of a mutant protein with a single amino acid change that disrupts the HP1a-Piwi interaction is unable to do so. We show that Piwi is stably bound to numerous sites along the meiotic chromosomes, including centromere proximal regions. In addition, reduction of HP1a or Piwi during meiotic prophase induces a significant increase in FM7a/X segregation errors. We present a speculative model outlining how HP1a and Piwi could collaborate to keep achiasmate chromosomes associated in a homology-dependent manner.
Reaktualisasi Pengamalan Nilai Pancasila untuk Demokrasi Indonesia
Authors: Mutiani Mutiani
Published: March 2016

Pancasila as an integral (comprehensively) is a solid supporting to the state established in Indonesia. Pancasila is maintained and developed with the aim to protect and develop the dignity and rights of all citizens of the nation to democracy in Indonesia. Posts in this article aims to explain how the urgency of re-actualization of Pancasila. As a method of this paper is literature study. The writer was conducting Pancasila in the context of political education in Indonesia emphasis on understanding the unity and integrity of the nation and the values listed in UUD 1945 with its main foundation of Pancasila. As the result, therefor, Pancasila is expected to realize the Good and Smart Citizenship, which, law-abiding citizens, to the literacy of citizens to political issues. Permalink/DOI: http://dx.doi.org/10.15408/sd.v2i2.2822
Parent Mentors and Insuring Uninsured Children: A Randomized Controlled Trial
Authors: Flores Glenn , Lin Hua , Walker Candy , Lee Michael , Currie Janet M. , Allgeyer Rick , Fierro Marco , Henry Monica , Portillo Alberto , Massey Kenneth
Published: March 2016

BACKGROUND:

Six million US children are uninsured, despite two-thirds being eligible for Medicaid/Children’s Health Insurance Program (CHIP), and minority children are at especially high risk. The most effective way to insure uninsured children, however, is unclear.

METHODS:

We conducted a randomized trial of the effects of parent mentors (PMs) on insuring uninsured minority children. PMs were experienced parents with ≥1 Medicaid/CHIP-covered child who received 2 days of training, then assisted families for 1 year with insurance applications, retaining coverage, medical homes, and social needs; controls received traditional Medicaid/CHIP outreach. The primary outcome was obtaining insurance 1 year post-enrollment.

RESULTS:

We enrolled 237 participants (114 controls; 123 in PM group). PMs were more effective (P< .05 for all comparisons) than traditional methods in insuring children (95% vs 68%), and achieving faster coverage (median = 62 vs 140 days), high parental satisfaction (84% vs 62%), and coverage renewal (85% vs 60%). PM children were less likely to have no primary care provider (15% vs 39%), problems getting specialty care (11% vs 46%), unmet preventive (4% vs 22%) or dental (18% vs 31%) care needs, dissatisfaction with doctors (6% vs 16%), and needed additional income for medical expenses (6% vs 13%). Two years post-PM cessation, more PM children were insured (100% vs 76%). PMs cost $53.05 per child per month, but saved $6045.22 per child insured per year.

CONCLUSIONS:

PMs are more effective than traditional Medicaid/CHIP methods in insuring uninsured minority children, improving health care access, and achieving parental satisfaction, but are inexpensive and highly cost-effective.
MINERAÇÃO EM BASES DE DADOS DO INEP: UMA ANÁLISE EXPLORATÓRIA PARA NORTEAR MELHORIAS NO SISTEMA EDUCACIONAL BRASILEIRO
Authors: Fonseca Stella Oggioni da , Namen Anderson Amendoeira
Published: March 2016

RESUMO: O Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP) possui bases de dados provenientes de levantamentos estatísticos e avaliativos em diversos níveis e modalidades de ensino, incluindo a Educação Básica, cuja avaliação é efetuada pelo Sistema de Avaliação da Educação Básica (Saeb). Com o intuito de analisar o Ensino Fundamental público brasileiro, o Saeb é composto de uma avaliação denominada Prova Brasil, que, por intermédio da aplicação de testes e questionários aos alunos, professores e diretores, torna possível a extração de informações relevantes para identificação de caminhos visando à melhoria da qualidade do ensino. Mediante o desafio de explorar esta base, constituída de um grande volume de dados, este estudo aplica o processo de Descoberta de Conhecimento em Bancos de Dados (Knowledge Discovery in Databases - KDD) com o intuito de identificar fatores que relacionam o perfil de professores que lecionam Matemática com a proficiência obtida por seus alunos. São apresentados os passos deste processo no contexto desta aplicação, explicitando, principalmente, a Mineração de Dados (Data Mining). Por fim são tecidos comentários sobre os padrões descobertos.
PROFISSIONALIZAÇÃO DOCENTE EM UMA ESCOLA PRIVADA DE SETORES POPULARES: SEGUINDO O FIO DE ARIADNE
Authors: Mury Rita de Cassia Ximenes , Lélis Isabel Alice Monteiro
Published: March 2016

RESUMO: Este trabalho é parte de uma pesquisa realizada em escola privada frequentada por setores populares. Focalizando a profissionalização docente marcada por esse contexto, optou-se pela utilização das histórias de vida como principal instrumento para aferição dos dados. Os conceitos de trajetória, campo e habitus desenvolvidos por Bourdieu foram centrais na análise. Além disso, os estudos de Nóvoa, Valle e Fanfani ajudaram na construção e na discussão dos dados. A investigação evidencia um processo de profissionalização ímpar, marcado por uma aderência à profissão construída no processo de formação, na vivência da docência e por gosto aprendido, identificado pelas professoras como "vocação". Discute-se como as relações quase familiares estabelecidas nesse espaço fomentam um caminho singular à trajetória profissional docente. Finalmente, aponta-se a importância de que a profissionalização docente seja compreendida a partir dos contextos concretos de atuação e das trajetórias de vida dos professores, tendo em vista a heterogeneidade característica dessa profissão.
COLÉGO ESTADUAL CENTRAL: AUTOGOVERNO E PRODUÇÃO SOCIAL DA EXCELÊNCIA NO ENSINO SECUNDÁRIO (BELO HORIZONTE, 1956-1964)
Authors: Lisboa Aleluia Heringer , Gouvea Maria Cristina Soares de
Published: March 2016

Resumo: O texto busca analisar a construção social de excelência no Colégio Estadual Central de Belo Horizonte, escola pública de referência no ensino secundário de Minas Gerais. Foi contemplado o período entre a implantação da nova sede, em 1956, e a criação de sedes anexas, evento contemporâneo ao fim do regime democrático, em 1964. Tais acontecimentos marcaram uma ruptura com as representações de excelência e liberdade, elementos identitários da instituição. Tendo como fontes dados de matrícula, aprovação e caracterização social dos alunos, jornais de época e entrevistas com ex-alunos e ex-professores, buscou-se analisar como a excelência do ensino e o autogoverno do aluno na gestão da aprendizagem definiram-se como características distintivas da instituição. Para tal foram contemplados: o projeto arquitetônico, desenvolvido por Oscar Niemeyer, a origem social e capital cultural dos alunos, o rigor dos processos seletivos e avaliativos, a excelência de ensino e formação, práticas de sociabilidade e ação política.