bluuebunny/crossref_metadata_2025 huggingface dataset:
Percutaneous treatment of aortic isthmus atresia
Authors: Butera Gianfranco , Heles Mohamed , Carminati Mario
Published: July 2011

Background: Limited data exists in the literature concerning the percutaneous treatment of complete aortic isthmus atresia. Patients and Methods: Between January 2007 and November 2010, 40 subjects underwent percutaneous treatment of aortic coarctation in our catheterization laboratory. Four out of 40 had aortic isthmus atresia with complete interruption. Median age at procedure was 48 years (range, 32–63 years). All subjects had history of arterial systemic hypertension refractory to medical treatment. Two subjects had a previous history of haemorrhagic stroke. All procedures were performed under general anesthesia and orotracheal intubation. In each case radial and femoral artery access was obtained. A radiofrequency (RF) system (Baylis MedComp Inc, Montreal, Canada) consisting of a Nykanen 0.024'' RFguidewire and coaxial microcatheter were used to perforate and cross the atretic segment. A guidewire was then snared and an artero‐arterial circuitcreated. The area was predilated by using coronary angioplasty balloons. A 12 Fr Mullins long sheath was advanced and an E‐PTFE covered 8Zig Cheatham‐Platinum stent implanted. Patients were monitored in hospital for 48–72 hr. Follow‐up was performed at 1, 3, 6, 12 months, and yearly thereafter. Results: Percutaneous recanalization of the atretic segment was performed successfully in all subjects. Mean fluoroscopy and procedure times were 30 ± 6 and 90 ± 15 min, respectively. After implantation, the gradient decreased significantly (prestent: mean value 52.25 mm Hg [range 33–70 mm Hg] versus post stent: mean value 3 mm Hg [range, 0–10 mm Hg] [P < 0.0001]). The stents were placed in the correct position in all subjects and no immediate complications occurred. During a mean follow‐up of 19 months (2–41 months), there were nosignificant complication. All subjects had arterial systemic blood pressure within the normal range. In two out of four patients single agent antihypertensive drug therapy was needed. The first patient in our series was treated conservatively and needed further stent dilation with a second procedure approach, eight months after the initial stent implantation, performed without incident. Conclusions: Our data show that use of radiofrequency energy perforation and covered CP stent implantation is a safe, effective, and promising tool for treatment of complete aortic isthmus atresia. © 2011 Wiley Periodicals, Inc.
Core valve embolization: Technical challenges and management
Authors: Sarkar Kunal , Ussia GianPaolo , Tamburino Corrado
Published: July 2011

Transcatheter Aortic Valve Implantation with the Core Valve self expanding prosthesis can be complicated by hemodynamic instability in cases of low deployment (implant failure). The management of a low implant may necessitate repositioning the prostheses with the help of a snare catheter. Snaring can however be complicated by embolization of the prosthesis which presents a series of technical challenges that need to be addressed. We have discussed the technical issues and the approach to address them successfully in a systematic manner to ensure optimal procedural and patient outcomes. © 2011 Wiley Periodicals, Inc.
Carotid artery revascularization with distal protection in high‐surgical‐risk patients in routine clinical practice: Rationale and design of the CABANA safety surveillance program
Authors: White Christopher J. , Avula Surendra B. , Mintz Randy T. , Iskander Ayman , Chervu Arun , Feldman Robert L. , Schermerhorn Marc L. , Woo Henry H. , Hopkins L. Nelson
Published: July 2011

Background: Continuous improvement in carotid artery stenting (CAS) outcomes, especially for periprocedural death and stroke in high‐surgical‐risk patients, have been seen in recent randomized trials of CAS versus carotid endarterectomy and CAS registries. However, these studies use stringent inclusion/exclusion criteria for patient, institution, and physician selection. The Carotid Stenting Boston Scientific Surveillance Program (CABANA) study was initiated to evaluate periprocedural outcomes with modern versions of the Carotid Wallstent and FilterWire EZ System for operators with a wide range of clinical specialties, CAS experience and training levels, in patients with a broad range of high‐surgical‐risk conditions and lesion types. Methods: This prospective, single‐arm study enrolled 1,097 subjects with 1,098 carotid artery lesions at 99 study centers. Investigators were grouped into one of three tiers according to whether they had a high, medium, or low level of previous CAS experience and were also categorized by their CAS‐credential‐based training requirements for the CABANA study. Follow‐up at 30 days includes clinical evaluation and independent neurological and NIH stroke scale assessments. The primary endpoint rate of 30‐day composite stroke, death, and MI, as well as the rates of these individual events, will be evaluated across the overall study, by physician experience tier, and by physician training tier. Discussion: The evaluation of periprocedural CAS safety in a real‐world environment with modern devices in high‐surgical‐risk patients treated by physicians with a broad range of training and experience will better inform treatment decisions in the future. © 2011 Wiley Periodicals, Inc.
The effects of a bare metal stent on the healing of a huge coronary pseudoaneurysm: A case report
Authors: Shintani Yoshiaki , Kawasaki Tomohiro
Published: July 2011

We experienced a rapidly growing huge coronary pseudoaneurysm with symptomatic restenosis after rotational atherectomy. A BMS had successfully obliterated the huge coronary pseudoaneurysm at 3 months follow‐up on CTA. The OCT at 9 months follow‐up showed that the most of stent strut was covered with neo‐intima. This case suggests that BMS deployment is recommended as a useful method for treating coronary pseudoaneurysms. © 2011 Wiley Periodicals, Inc.
Intravascular ultrasound assessment of distal left main bifurcation disease: The importance of the polygon of confluence of the left main, left anterior descending, and left circumflex arteries
Authors: Kang Soo‐Jin , Mintz Gary S. , Oh Jun‐Hyok , Park Duk‐Woo , Lee Seung‐Whan , Kim Young‐Hak , Lee Cheol Whan , Park Seong‐Wook , Park Seung‐Jung
Published: July 2011

Background: The polygon of confluence (POC) represents the zone of confluence of the distal left main (LM), ostial left anterior descending (LAD), and ostial left circumflex (LCX) arteries. Methods: We used intravascular ultrasound (IVUS) to assess the POC pre and post‐drug‐eluting stent implantation for unprotected distal LM disease. Four segments within 82 LM bifurcation lesions were defined by longitudinal IVUS reconstruction: (1) ostial LAD, (2) POC, and (3) distal LM (DLM)—from LAD‐pullback, and (4) ostial LCX from LCX‐pullback. Results: Preprocedural minimum lumen area (MLA) and poststenting minimum stent area (MSA) within the LM were mainly located within the POC (51 and 71%). On ROC analysis, a cut‐off of the MLA within the POC of 6.1 mm2 predicted significant LCX carinal stenosis (85% sensitivity, 52% specificity, AUC = 0.7, 95% CI = 0.57–0.78, P < 0.01). Poststenting MSA within the distal LM proximal to the carina (to include DLM and POC) positively correlated with the preprocedural MLA within the POC (r = 0.283, P = 0.02); it was significantly smaller in 48 lesions with a pre‐PCI MLA within the POC < 6.1 mm2 versus 25 lesions with a pre‐PCI MLA ≥6.1 mm2 (7.5 ± 2.1 mm2 vs. 8.6 ± 2.0 mm2, P = 0.04). Independent predictors for poststenting LCX carinal MLA also included preprocedural MLA within the POC (β = 0.240, 95% CI = 0.004–0.353, P = 0.04). Conclusion: The MLA within the POC was a good surrogate reflecting the overall severity of LM bifurcation disease including ostial LCX stenosis pre‐PCI and the ability to expand a stent within the distal LM as well as final ostial LCX lumen area post‐PCI. © 2011 Wiley Periodicals, Inc.
Transapical treatment of paravalvular leaks in patients with a logistic euroscore of more than 15%
Authors: Swaans Martin J. , Post Martijn C. , van der Ven H. A. Johan , Heijmen Robin H. , Budts Werner , ten Berg Jurien M.
Published: July 2011

Objective: We describe the short‐term results of the patients who underwent transapical treatment of a paravalvular leak (PVL) in our centre.

Background: Increasing experience with transapical aortic valve implantation has inspired us to explore this approach for prosthetic paravalvular leak reduction in high risk patients.

Methods: All procedures were performed in the catheterization laboratory under general anesthesia, using a small anterolateral thoracotomy to expose the apex. Access through a 9‐French sheath was necessary to introduce the Amplatzer Vascular III plug. Three‐dimensional transesophageal echocardiography (3D‐TEE) was used to guide the operator and evaluate the severity of regurgitation postimplantation.

Results: In total seven consecutive patients (mean age 72.8 ± 5.6 years, 86% male) with a history of mitral valve (n = 6) or aortic valve replacement and severe PVL, underwent transapical PVL reduction using seven plugs in total (diameter 10–14 mm). Preprocedural median logistic EuroSCORE was 28.5% (range 17.1–41.1%) and NYHA functional class was ≥3 in all patients. The procedure was successful in all patients, with a median fluoroscopic time of 18.7 min (range 10.1–29.6 min). Postprocedure 3D‐TEE showed occlusion of PVL in three patients, and significant reduction in three patients. Postprocedural complication was a hematothorax requiring surgery in one patient. Median hospitalization duration after the procedure was 5 days (range 5–59 days). At 3‐month follow‐up one patient died, functional class and LDH did not differ significantly and there was a significant increase in hemoglobin.

Conclusions: Transapical paravalvular leak reduction might be a good or rather attractive alternative in high‐risk patients for major re‐do cardiac surgery. © 2011 Wiley Periodicals, Inc.
A neglected symptom of contained aortic laceration—Dysphagia aortica successfully treated by endovascular stentgrafting
Authors: Kische Stephan , Werner Dierk , Ince Hüseyin
Published: July 2011

Purpose: Dysphagia aortica describes an esophageal swallowing disorder caused by external compression from an ectatic, tortuous, or aneurysmal thoracic aorta. Although well recognized among specialists, dysphagia aortica is rarely considered in the differential diagnosis of dysphagia. Case Report: We present the case of a 75‐year‐old woman with a history of swallowing difficulty and retrosternal pressure sensation. Her symptoms had been attributed to sliding axial hernia along with gastroesophageal reflux disease for the last 12 months. Diagnostic workup at our institution revealed a giant penetrating ulcer of the descending aorta as a culprit of esophageal compression. Expeditious endovascular stentgraft exclusion of the aneurysm was performed because of its symptomatic nature and high propensity of spontaneous rupture. On a recent consultation 2 years after the endovascular procedure, the patient confirmed a complete remission of impaired swallowing and freedom from thoracic discomfort. Conclusions: Dysphagia aortica should be considered in the numerous differential diagnoses of esophageal swallowing disorders in the elderly, as delayed identification may harbor catastrophic outcome for affected individuals. © 2011 Wiley Periodicals, Inc.
Percutaneous coronary interventions and cardiovascular outcomes for patients with chronic total occlusions
Authors: Jolicœur E. Marc , Sketch Micheal J. , Wojdyla Daniel M. , Javaheri Sean P. , Nosib Shravan , Lokhnygina Yuliya , Patel Manesh R. , Shaw Linda K. , Tcheng James E.
Published: July 2011

Objectives: This study sought to assess the benefits of a coronary chronic total occlusion CTO recanalization after adjusting for the case‐mix and the propensity to undergo the CTO intervention in a population of patients with stable coronary artery disease. Background: The benefits of percutaneous recanalization of CTO are disputed. Methods: In 1,602 patients with a least one CTO and treated by percutaneous coronary intervention (PCI), we derived a propensity score to undergo a CTO recanalization by comparing the characteristics of patients who did (n = 346) and did not (n = 1,256) undergo a CTO PCI attempt. Among the patients who underwent a CTO PCI attempt, we identified the angiographic predictors of failure. The primary analysis was ultimately performed by looking at the association between the outcome of the CTO recanalization and the survival free of death and cardiovascular rehospitalizations. Sensitivity analyses were performed by adjusting for the propensity to undergo a CTO recanalization, for the anatomical predictors of failure, and for the extent of coronary artery revascularization achieved. Results: A successful CTO recanalization was not significantly associated with survival free of death and cardiovascular rehospitalization (HR = 0.90, 95% CI 0.64–1.25). Even more conservative hazards ratio point estimates were obtained with the sensitivity analyses. Conclusions: Successful percutaneous CTO recanalization is not associated with survival free of death and cardiovascular hospitalizations in a contemporary population of patients with symptomatic coronary artery disease. © 2011 Wiley Periodicals, Inc.
Selective pulmonary artery embolization in two patients with single ventricle and acquired pulmonary vein occlusion
Authors: Bondanza Sara , Derchi Maria , Marasini Maurizio
Published: July 2011

Acquired pulmonary vein occlusion is a rare complication of surgical correction of complex congenital heart diseases. Associated vascular remodeling of arterial and venous vessels includes medial thickening, intimal fibrosis, and progressive development of aorto‐pulmonary collaterals. The consequent pulmonary perfusion changes impact more importantly on a low pressure circulation such as the Fontan circuit. The management of these patients is still controversial. We describe this condition in two patients with single ventricle who underwent staged cavopulmonary connection. In both cases, we found acquired occlusion of one pulmonary vein, poor antegrade flow in the involved hypoplastic pulmonary arteries due to a widespread thin collateral circulation producing a backward washout of unopacified blood flow with competitive mechanism. Percutaneous embolization of a segmental pulmonary artery was performed with restoration of a more homogeneous perfusion of both main pulmonary arteries. Extracardiac total cavopulmonary connection was successfully performed a few months later in both patients. © 2011 Wiley Periodicals, Inc.
Improved automated lumen contour detection by novel multifrequency processing algorithm with current intravascular ultrasound system
Authors: Kume Teruyoshi , Kim Byeong‐Keuk , Waseda Katsuhisa , Sathyanarayana Shashidhar , Li Wenguang , Teo Tat‐Jin , Yock Paul G. , Fitzgerald Peter J. , Honda Yasuhiro
Published: July 2011

Objectives: The aim of this study was to evaluate a new fully automated lumen border tracing system based on a novel multifrequency processing algorithm. Background: We developed the multifrequency processing method to enhance arterial lumen detection by exploiting the differential scattering characteristics of blood and arterial tissue. The implementation of the method can be integrated into current intravascular ultrasound (IVUS) hardware. Methods: This study was performed in vivo with conventional 40‐MHz IVUS catheters (Atlantis SR Pro™, Boston Scientific Corp, Natick, MA) in 43 clinical patients with coronary artery disease. A total of 522 frames were randomly selected, and lumen areas were measured after automatically tracing lumen borders with the new tracing system and a commercially available tracing system (TraceAssist™) referred to as the “conventional tracing system.” The data assessed by the two automated systems were compared with the results of manual tracings by experienced IVUS analysts. Results: New automated lumen measurements showed better agreement with manual lumen area tracings compared with those of the conventional tracing system (correlation coefficient: 0.819 vs. 0.509). When compared against manual tracings, the new algorithm also demonstrated improved systematic error (mean difference: 0.13 vs. −1.02 mm2) and random variability (standard deviation of difference: 2.21 vs. 4.02 mm2) compared with the conventional tracing system. Conclusions: This preliminary study showed that the novel fully automated tracing system based on the multifrequency processing algorithm can provide more accurate lumen border detection than current automated tracing systems and thus, offer a more reliable quantitative evaluation of lumen geometry. © 2011 Wiley Periodicals, Inc.
Incidence, timing, and predictors of valve dislodgment during TAVI with the medtronic corevalve system
Authors: Van Mieghem Nicolas M. , Schultz Carl J. , van der Boon Robert MA , Nuis Rutger‐Jan , Tzikas Apostolos , Geleijnse Marcel L. , van Domburg Ron T. , Serruys Patrick W. , de Jaegere Peter PT
Published: July 2011

Objectives: To determine the incidence, timing and predictors of periprocedural valve dislodgment with the Medtronic Corevalve System (MCS). Background: Periprocedural valve dislodgment may occur during transcatheter aortic valve implantation (TAVI). Methods: Ninety‐eight consecutive patients underwent TAVI with the MCS after a comprehensive baseline assessment including invasive angiography, echocardiography, and Multi‐Slice Computed Tomography (MSCT). The invasive monitoring charts and angiographic studies of all TAVI procedures were reviewed to determine the incidence and timing of valve dislodgment. Results: Valve dislodgment occurred in 18 patients. Patients with valve dislodgment had a larger Aortic Valve Area (0.76 ± 0.25 cm2 vs. 0.61 ± 0.19 cm2, P = 0.007), lower mean transaortic gradient (37.65 ± 14.62 mm Hg vs. 47.11 ± 16.08 mm Hg, P = 0.03) and significantly less aortic root calcification (Agatston score median 1951 AU (IQR, 799–3103) vs. 3289 AU (IQR 2097–4481), P = 0.016). A lower aortic root calcium score (Agatston score < 2359 AU) was the single independent predictor for valve dislodgment (OR 3.10, 1.09–8.84). After valve dislodgment, the valve could be successfully retrieved and implanted in the proper anatomic location in all cases. Valve dislodgment was associated with a lower incidence of post‐procedural AR ≥ 2 (11.1% vs. 34.6%, P = 0.05). There were no relevant procedural or clinical implications to valve dislodgment. Conclusions: The incidence of periprocedural valve dislodgment was 18% in these series. Less aortic root calcification appeared the single independent predictor. © 2011 Wiley Periodicals, Inc.
Transaortic transcatheter aortic valve implantation using edwards sapien valve
Authors: Bapat Vinayak , Khawaja Muhammed Z. , Attia Rizwan , Narayana Ashok , Wilson Karen , Macgillivray Kirsty , Young Christopher , Hancock Jane , Redwood Simon , Thomas Martyn
Published: July 2011

Objectives: To evaluate feasibility and outcome of Transoartic Transcatheter Sapien valve implantation. Background: Transcatheter Aortic valve implantation (TAVI) using the Edwards SAPIEN device (Edwards LifeScience, Irvine, CA) is usually performed via the transfemoral (TF) or transapical (TA) routes. Some patients are not suitable for these approaches. We report our experience with the novel transaortic (TAo) approach via a partial upper sternotomy and discuss the advantages and future applications. Methods: Between January 2008 to March 2011 193 patients with severe aortic stenosis underwent TAVI with the Edwards SAPIEN bioprosthesis at the St. Thomas' Hospital, London. 108 patients were unable to undergo a TF‐TAVI and of those 17 were accepted for a TAo‐TAVI on the basis of anatomy, risk, LV function, and significant respiratory disease. Results: The TAo‐TAVI group (n = 17) had more prevalent respiratory disease than the TA‐TAVI group (47.0% vs. 18.7%, P = 0.011). Otherwise the groups were similar in demographics and history. Despite this the 30 day mortalities were not significantly different between the groups (TAo‐TAVI 4.3% at 30 days versus TA‐TAVI 7.7%, P = 0.670). There were no significant differences in procedural complications. Conclusions: The TA‐TAVI approach may not be desirable in patients with severe chest deformity, poor lung function or poor left ventricular function. TAo‐TAVI via a partial sternotomy is safe and feasible in these patients. © 2011 Wiley Periodicals, Inc.
Pressure‐wire based assessment of microvascular resistance using calibrated upstream balloon obstruction
Authors: Kim June‐Hong , Park Ju‐Hyun , Choo Kiseok , Song Sung‐Kook , Kim Jung‐Su , Park Young‐Hyun , Kim Jun , Chun Kook‐Jin , Han Dongcheul , Faranesh Anthony Z. , Lederman Robert J.
Published: July 2011

Objectives: We assess microvascular integrity as a marker of myocardial viability after coronary stenting, using only a pressure guidewire. Background: Microvascular integrity generally is not assessed using pressure‐only guidewires because the transducer lies upstream of microvasculature. We partially inflate a balloon inside a coronary stent to achieve a specific normalized pressure drop at rest (distal coronary/aortic pressure = 0.8) and then infuse a vasodilator, to render the wire sensitive to microvascular function. We hypothesize that the further decline in pressure (ΔFFR0.8) predicts MRI myocardial viability. Methods: We studied 29 subjects with acute coronary syndrome including myocardial infarction. After successful culprit stenting, the resting coronary/aortic pressure was set to 0.8 using temporary balloon obstruction. ΔFFR0.8 was defined as 0.8‐(distal coronary/aortic pressures) during adenosine‐induced hyperemia. The average transmural extent of infarction was defined as the average area of MRI late gadolinium enhancement (after 2.8 ± 1.5 days) divided by the corresponding full thickness of the gadolinium enhanced sector in short axis slices, and was compared with ΔFFR0.8. Results: ΔFFR0.8 corresponded inversely and linearly with the average transmural extent of infarction (r2 = 0.65, P < 0.001). We found that a transmural extent of infarction of 0.50 corresponded to a ΔFFR0.8 threshold of 0.1, and had high sensitivity and specificity (100% and 94.4%, respectively). Conclusions: Using only an upstream pressure‐sensitive guidewire and a partially obstructing balloon during pharmacologic hyperemia, we were able to predict MRI myocardial viability with high accuracy after relief of epicardial stenosis. With further validation, this may prove a useful clinical prognostic tool after percutaneous intervention. © 2011 Wiley Periodicals, Inc.
Incidence, predictors, and prognostic value of intramyocardial hemorrhage lesions in ST elevation myocardial infarction
Authors: Amabile Nicolas , Jacquier Alexis , Shuhab Anes , Gaudart Jean , Bartoli Jean‐Michel , Paganelli Franck , Moulin Guy
Published: July 2011

Background: Intra myocardial hemorrhage lesions (IMH) are underdiagnosed complication of ST elevation myocardial infarction (STEMI). We sought to determine the incidence, predictors and the prognostic value of IMH in STEMI using cardiac MR imaging (CMR) techniques. Methods: We screened for inclusion consecutive patients with STEMI treated by percutaneous coronary intervention (PCI) within the first 12 hr of evolution. IMH lesions were identified on T2‐weighted sequences on CMR between days 4 and 8 after PCI. Adverse cardiac events were defined as a composite of death + severe ventricular arrhythmias + acute coronary syndrome + acute heart failure. Results: N = 114 patients were included and n = 11 patients (10%) presented IMH lesions. Patients with IMH lesions had a larger myocardial infarction extent (25.6 ± 1.8 vs. 13.5 ± 1.0 % LV mass, P < 0.01), microvascular obstructive lesions extent (4.6 ± 1.0 vs. 1.3 ± 0.3% LV mass, P < 0.01) and lower LV ejection fraction (40.7 ± 2.3% vs. 50.7 ± 1.3%, P < 0.01). The value of glycemia at admission was an independent predictor of IMH development (Odd ratio 1.8 [1.1–2.8] per mmol l−1, P = 0.01). The incidence of adverse cardiac events was higher in the IMH group than in the non‐IMH group during the first year following STEMI (P = 0.01, log‐rank analysis). Cox regression analysis identified the presence of IMH lesions as an independent predictor of adverse clinical outcome (Hazard Ratio = 2.8 [1.2–6.8], P = 0.02). Conclusion: Our study indicates that IMH is a rare but severe finding in STEMI, associated with a larger myocardial infarction and a worse clinical outcome. Per‐PCI glycemia might influence IMH development. © 2011 Wiley Periodicals, Inc.
Impact of intravascular ultrasound‐guided percutaneous coronary intervention on long‐term clinical outcomes in a real world population
Authors: Hur Seung‐Ho , Kang Soo‐Jin , Kim Young‐Hak , Ahn Jung‐Min , Park Duk‐Woo , Lee Seung‐Whan , Yun Sung‐Cheol , Lee Cheol Whan , Park Seong‐Wook , Park Seung‐Jung
Published: July 2011

Objectives: To compare long‐term clinical outcomes between intravascular ultrasound (IVUS)‐guided and angiography‐guided percutaneous coronary intervention (PCI) in a large “real world” registry. Background: The impact of IVUS‐guided PCI on clinical outcomes remains unclear. Methods: Between January 1998 and February 2006, 8,371 patients who underwent IVUS‐ (n = 4,627) or angiography‐ (n = 3,744) guided PCI were consecutively enrolled. Three‐year clinical outcomes were compared after adjustment for inverse‐probability‐of‐treatment weighting (IPTW) in the overall population and in separate populations according to stent type. Results: A crude analysis of the overall population showed that the 3‐year mortality rate was significantly lower in the IVUS‐guided group than in the angiography‐guided group (96.4% ± 0.3% vs. 93.6% ± 0.4%, log‐rank P < 0.001). When adjusted by IPTW, patients undergoing IVUS‐guided PCI remained at lower risk of mortality (hazard ratio [HR] 0.627; 95% CI 0.50–0.79, P < 0.001). Similarly, in the drug‐eluting stent (DES) population, the 3‐year risk of mortality was significantly lower in patients undergoing IVUS‐guided PCI (HR 0.46; 95% CI 0.33–0.66, P < 0.001). In contrast, IVUS‐guided PCI did not reduce the risk of mortality in the bare metal stent population (HR 0.82; 95% CI 0.60–1.10, P = 0.185). However, the risks of myocardial infarction (HR 0.95; 95% CI 0.63–1.44, P = 0.810), target vessel revascularization (HR 1.00; 95% CI 0.86–1.15, P = 0.944), and stent thrombosis (HR 0.82; 95% CI 0.53–1.07, P = 0.109) were not associated with IVUS guidance. Conclusions: IVUS‐guided PCI may reduce long‐term mortality when compared with conventional angiography‐guided PCI. This may encourage the routine use of IVUS for PCI in patients undergoing DES implantation. © 2012 Wiley Periodicals, Inc.
Feasibility of FiberNet® embolic protection system in patients undergoing angioplasty for atherosclerotic renal artery stenosis
Authors: Laird John R. , Tehrani Faramarz , Soukas Peter , Joye James D. , Ansel Gary M. , Rocha‐Singh Krishna
Published: July 2011

Objective: To evaluate the procedural safety and filter efficiency of Lumen Biomedical FiberNet® embolic protection system in conjunction with primary stenting of ostial atherosclerotic renal artery lesions. Background: There is limited data regarding the utility of distal embolic protection devices in renal artery angioplasty and stenting. Methods: Patients with angiographically severe (≥70%) renal artery stenosis were prospectively enrolled if one or more inclusion criteria met: resistant hypertension, progressive chronic kidney disease, unexplained heart failure, or flash pulmonary edema. Patients underwent renal artery angioplasty and stenting with utilization of the Lumen Biomedical FiberNet® EPS. The protection devices and aspirate were analyzed for degree of atheromatous particles. Procedural safety and clinical outcomes were assessed through 6 months. Results: Twenty patients were prospectively enrolled at five centers; average age 73.8 (±9.5) years, mean baseline eGFR 60.8 cm3 min−1. Twenty‐five renal artery stenting procedures were performed. Device and procedural success were achieved in 100% of cases. All patients tolerated the procedure without any adverse events. Embolic debris was captured in all cases. Debris analysis of the distal protection system displayed an average post procedure atheroma area of 51.31 mm2. There was no clinical evidence of peripheral atheroembolization through 30‐days follow‐up. No subjects progressed to temporary or permanent renal replacement therapy. Favorable trends in blood pressure control were observed at 6 months. Conclusion: The Lumen Biomedical FiberNet® embolic protection system is a safe and feasible method to prevent atheroembolization associated with angioplasty and stenting of renal artery ostial lesions. © 2011 Wiley Periodicals, Inc.
Differential 1‐year clinical outcomes for ST‐segment elevation myocardial infarction related to stent thrombosis or saphenous vein graft thrombosis
Authors: Arzamendi Dabit , Ly Hung Q. , Tanguay Jean‐François , Armero Sebastien , Jilaihawi Hasan , Gallo Richard , Ibrahim Reda , L'Allier Philippe , Blondeau Lucie , Gosselin Gilbert , Gregoire Jean , Doucet Serge
Published: July 2011

Aim: Thrombosis of stents and of saphenous vein grafts (SVG) remains a severe complication of either revascularization techniques that often are present as ST elevation myocardial infarction (STEMI). The aim of this longitudinal cohort study was to compare the 1‐year clinical outcomes among STEMI patients requiring primary PCI due to stent thrombosis and graft occlusion presenting with STEMI. Methods and Results: We prospectively collected data on all patients undergoing primary PCI at the Montreal Heart Institute between April 1, 2007 and March 30, 2008. Study patients were grouped according to the etiology of the STEMI: stent thrombosis, graft thrombosis, or atherosclerosis‐related STEMIs (control group). The primary combined end‐point, major adverse cardiac events (MACE), was defined as death, myocardial infarction, and target vessel revascularization within 12 months as primary end point. Of the 489 STEMI patients included in the study, 23 were due to stent thrombosis, 22 to graft thrombosis, and 444 in the control group. Stent and graft thromboses were associated with a higher MACE rates, 26.1 and 22.7%, respectively, compared to the control group, 9.3% (P = 0.004). Moreover, only stent thrombosis was associated with an increased risk of MACE (HR 2.57, confidence interval 95% 1.08–6.08. Conclusion: Patients with stent thrombosis present with higher rate of reinfarction while graft thrombosis is associated with an increase in 1‐year cardiac mortality. Using multivariate analysis, higher MACE rates were associated with stent thrombosis as compared to graft thrombosis. © 2013 Wiley Periodicals, Inc.
Taming the “cobra”: An approach to “Cobra‐Like” formation seen in the occlutech atrial septal defect and patent foramen ovale occluders
Authors: Aaron Sagiv , Mainzer Gur , Lorber Avraham
Published: July 2011

Percutaneous closure of secundum atrial septal defect and patent foramen ovale has gained widespread use in recent years. We present a small series of four cases in which a “cobra‐like” formation occurred in an Occlutech Figulla device during the deployment of the left disk, and propose a technique that may resolve this problem. © 2011 Wiley Periodicals, Inc.
Restenosis after stent implantation for superficial femoral artery disease in patients treated with cilostazol
Authors: Soga Yoshimitsu , Iida Osamu , Hirano Keisuke , Suzuki Kenji , Yokoi Hiroyohi , Nobuyoshi Masakiyo
Published: July 2011

Background: Restenosis after endovascular treatment for superficial femoral artery (SFA) disease remains a significant clinical issue. We assessed whether cilostazol reduce restenosis after SFA stenting with self‐expandable nitinol stent. Methods: The study was a multicenter, prospective maintained database, retrospective analysis. From April 2004 to December 2009, 861 consecutive patients (mean age 71 years, 71% male) who underwent successful stenting for de novo lesions were retrospectively identified. Of them, 492 received cilostazol (cilostazol(+)) and 369 did not receive cilostazol (cilostazol(−)) after procedure. Propensity‐score analyses matched 281 cilostazol(+) with 281 cilostazol (−) group. Primary endpoint was binary restenosis rate. Secondary endpoints were reocclusion, all‐cause mortality and limb salvage in patients with critical limb ischemia (CLI). Restenosis was defined as >2.4 of peak systolic velocity ratio by duplex. Results: Mean follow‐up period was 25 months. According to analysis of matched pairs, binary restenosis rates were significantly lower (31.2% vs. 42.9% at 5‐year, P = 0.02). In‐stent re‐occlusion rate tended to be lower in patients who received cilostazol (10.8% vs. 18.2% at 5‐year, P = 0.09) compared with control. No significant difference of all‐cause mortality (21.4% vs. 18.3% at 5‐year, P = 0.84) and limb salvage rate in patients with CLI (86.2% vs. 78.5% at 5‐year, P = 0.29) was found between both groups. After adjustment for prespecified risk factors, cilostazol was an independent negative predictor of restenosis. In subgroup analysis, male, age <75 years, claudicant patients, TASCII C/D, small vessels and poor runoff vessel was significantly lower in binary restenosis. Conclusions: Cilostazol reduced restenosis after SFA stenting with self‐expandable nitinol stent and it seems to be more effective in high‐risk patients for restenosis. © 2011 Wiley Periodicals, Inc.
Stereoselective Oxidation of 1‐Phenyl‐1,2‐propanediol Mediated by Microorganisms
Authors: Martins Rodrigo S. , Zampieri Dávila S. , Rodrigues J. Augusto R. , Carvalho Patrícia O. , Moran Paulo J. S.
Published: July 2011

The enantioselective oxidation of (1R,2S)‐1‐phenyl‐1,2‐propanediol [(1R,2S)‐1], mediated by baker’s yeast, gave (−)‐(S)‐1‐phenyl‐2‐hydroxy‐1‐propanone [(S)‐2] in 64 % isolated yield and 93 % ee. Kinetic experiments of the bio‐oxidation of (±)‐anti‐1 revealed that the enantiomer (1R,2S)‐1 was more reactive than (1S,2R)‐1. Therefore, this result allowed us to devise a kinetic resolution experiment to obtain (1S,2R)‐1 in >99 % ee from (±)‐anti‐1. The preparation of (1S,2R)‐1 is interesting, as it is the antipode of the product obtained by the reduction of 1‐phenyl‐1,2‐propanedione using baker’s yeast. Other microorganisms, such as Micrococcus luteus, Candida albicans, and Geotrichum candidum, were also used for kinetic resolution experiments of (±)‐anti‐1. The best result was obtained using Geotrichum candidum, which gave (1S,2R)‐1 in 32 % yield and 99 % ee.
ChemInform Abstract: Crystal Structure and Properties of the Manganese Containing Swedenborgite YBaMn3AlO7.
Authors: Valldor M. , Breunig O.
Published: July 2011

Small crystals of the title compound are grown from BaAl2O4, Y2BaO4, and MnO in a floating‐zone mirror‐image furnace.
ChemInform Abstract: Crystal Growth and Optical Properties of Lithium—Lanthanide Oxides: LiLnO2 (Ln: Nd, Sm, Eu, Gd and Dy).
Authors: Cantwell Jacqueline R. , Roof Irina P. , Smith Mark D. , zur Loye Hans‐Conrad
Published: July 2011

Single crystals of the title compounds are prepared from Ln2O3 and LiOH (Ag tubes, 700 °C, 12 h) and characterized by single crystal XRD and photoluminescence spectroscopy.
ChemInform Abstract: Synthesis and Thermal Conductivities of ZnIn2Te4 and CdIn2Te4 with Defect‐Chalcopyrite Structure.
Authors: Suriwong Tawat , Kurosaki Ken , Thongtem Somchai , Harnwunggmoung Adul , Plirdpring Theerayuth , Sugahara Tohru , Ohishi Yuji , Muta Hiroaki , Yamanaka Shinsuke
Published: July 2011

The title compounds are prepared by solid state reactions of stoichiometric mixtures of Zn or Cd, In2Te3, and Te (sealed silica tubes, 1053—1173 K, 3 d).
ChemInform Abstract: Na5(Ga4S) (GaS4)3·6H2O: A Three‐Dimensional Thiogallate Containing a Novel Octahedral Building Block.
Authors: Rumble Jack , Vaqueiro Paz
Published: July 2011

Single crystals of the new title compound are solvothermally synthesized from a mixture of Ga2S3, S, tryptamine, and sodium imidazolate in aqueous 3,5‐dimethyl pyridine (autoclave, 200 °C, 10 d).
ChemInform Abstract: Silver(II) Fluorosulfate: A Thermally Fragile Ferromagnetic Derivative of Divalent Silver in an Oxa‐Ligand Environment.
Authors: Malinowski Przemyslaw J. , Derzsi Mariana , Mazej Zoran , Jaglicic Zvonko , Leszczynski Piotr J. , Michalowski Tomasz , Grochala Wojciech
Published: July 2011

Two novel routes to synthesize Ag(SO3F)2 are reported: methathesis reaction between Ag(SbF6)2 and KSO3F in anhydrous HF (‐84→+25 °C; ≈100% yield) and reaction of AgF2 with HSO3F (25—50 °C, 4 d).
ChemInform Abstract: Resolution of Carboxylic Acids Using Copper(I)‐Promoted Removal of Propargylic Esters under Neutral Conditions.
Authors: Ghosh Partha , Aube Jeffrey
Published: July 2011

A mild and straightforward method for the resolution of various carboxylic acids is reported.
ChemInform Abstract: Enantioselective Henry Reaction Catalyzed by Copper(II)—Cinchona Alkaloid Complexes.
Authors: Zielinska‐Blajet Mariola , Skarzewski Jacek
Published: July 2011

A simple catalytic system made of quinine and copper acetate increases the diastereoselectivity and enantioselectivity of Henry reactions.
ChemInform Abstract: Visible‐Light‐Induced Photoreductive Generation of Radicals from Epoxides and Aziridines.
Authors: Larraufie Marie‐Helene , Pellet Remy , Fensterbank Louis , Goddard Jean‐Philippe , Lacote Emmanuel , Malacria Max , Ollivier Cyril
Published: July 2011

Epoxides substituted by an aryl ketone are efficiently reduced using different visible‐light photoredox catalysts under irradiation with a 14 W fluorescent light bulb.
ChemInform Abstract: An Efficient Oxidation of Benzylic and Alicylic Compounds with Water‐Soluble Copper Catalysts in t‐Butyl Hydroperoxide at Room Temperature.
Authors: Rahman Ateeq , Al Zahrani S. M. , Ajjou Abdel Aziz Nait
Published: July 2011

The selective oxidation of benzylic hydrocarbons gives the corresponding ketones in good yields.
ChemInform Abstract: Synthesis of Amino Thiols and Isocysteines via Regioselective Ring Opening of Sulfamidates with Tetrathiomolybdate.
Authors: Baig R. B. Nasir , Kumar N. Y. Phani , Mannuthodikayil Jamsad , Chandrasekaran Srinivasan
Published: July 2011

A highly efficient synthesis of β‐ and γ‐amino thiols starting from diols is presented.
ChemInform Abstract: N‐Alkylation of Poor Nucleophilic Amines and Derivatives with Alcohols by a Hydrogen Autotransfer Process Catalyzed by Copper(II) Acetate: Scope and Mechanistic Considerations.
Authors: Martinez‐Asencio Ana , Ramon Diego J. , Yus Miguel
Published: July 2011

The N‐alkylation of weakly nucleophilic amines (I), carboxamide (XIII), sulfonamides (XI), phosphazene (IV), and phosphinamide (VII) with primary and secondary alcohols is smoothly catalyzed by simple and inexpensive copper acetate in the presence of the strong base tBuOK.
ChemInform Abstract: Palladium‐Catalyzed, Stereoselective, Cyclizative Alkenylboration of Carbon—Carbon Double Bonds Through Activation of a Boron—Chlorine Bond.
Authors: Daini Masaki , Suginome Michinori
Published: July 2011

The 5‐exo cyclization mode and the high diastereoselectivity are the key features in the title carboboration of alkenylzirconium reagents such as (II) or (XI).
ChemInform Abstract: Transition‐Metal Chloride Mediated Addition Reaction of Diorganomagnesium to Easily Enolizable Ketones.
Authors: Sada Mutsumi , Matsubara Seijiro
Published: July 2011

A combination of organylmagnesium reagent with FeCl2 or YbCl3 generates a complex reagent that undergoes nucleophilic addition to enolizable ketones like α‐tetralone (I) prior to enolization.
ChemInform Abstract: Stereospecific Benzyne‐Induced Olefination from β‐Amino Alcohols and Its Application to the Total Synthesis of (‐)‐1‐Deoxy‐D‐fructose.
Authors: Hwu Jih Ru , Hsu Yung Chang
Published: July 2011

Treatment of acyclic as well as cyclic β‐amino alcohols with carbon disulfide under basic conditions gives thiazolidine thiones, which are further treated with in situ generated benzyne.
ChemInform Abstract: Borinic Acid Catalyzed α‐Addition to Isocyanide with Aldehyde and Water.
Authors: Soeta Takahiro , Kojima Yuuki , Ukaji Yutaka , Inomaa Katsuhiko
Published: July 2011

Various α‐hydroxyamides are synthesized.
ChemInform Abstract: Synthesis of Conjugated Enynes from Ketones and Aldehydes by 1,2‐CC Insertion and 1,2‐CH Insertion of Carbenoids as the Key Reactions.
Authors: Ishida Naoyuki , Saitoh Hideki , Sugiyama Simpei , Satoh Tsuyoshi
Published: July 2011

Addition of lithium acetylides towards chlorovinyl tolyl sulfoxides provides the corresponding adducts, e.g. (III), as mixtures of diastereomers.
ChemInform Abstract: Applications of Transition Metal Complexes Containing Aminophosphine Ligand to Transfer Hydrogenation Ketones.
Authors: Aydemir Murat , Baysal Akin , Turgut Yilmaz
Published: July 2011

Three aminophosphine complexes are prepared and their catalytic activity in the transfer hydrogenation of acetophenone derivatives is investigated.
ChemInform Abstract: Reductive Carbonylation of Aryl and Heteroaryl Iodides Using Pd(acac)2/dppm as an Efficient Catalyst.
Authors: Singh Abhilash S. , Bhanage Bhalchandra M. , Nagarkar Jayashree M.
Published: July 2011

Optimized reaction conditions are developed.
ChemInform Abstract: Selective Formation of Imines by Aerobic Photocatalytic Oxidation of Amines on TiO2.
Authors: Lang Xianjun , Ji Hongwei , Chen Chuncheng , Ma Wanhong , Zhao Jincai
Published: July 2011

The process involves a highly selective formation of aldehydes, whose further condensation with unreacted or in situ generated amines affords the corresponding imines.
ChemInform Abstract: Organocatalytic Conjugate Addition of 2‐Arylacetates and 2‐Arylacetonitriles Having an Electron‐Withdrawing Group to α,β‐Unsaturated Ketones.
Authors: Do Jungho , Kim Sung‐Gon
Published: July 2011

The process forms the corresponding products with low diastereoselectivity.
ChemInform Abstract: Chiral Dinuclear Phthalazine‐Bridged Bisoxazoline Ligands: Synthesis and Application in Enantioselective Cu‐Catalyzed Conjugate Addition of ZnEt2 to Enones.
Authors: Zhang Liang , Yang Guoqiang , Shen Chaoren , Arghib Sabah , Zhang Wanbin
Published: July 2011

A novel class of ligands, represented by PBO, is developed and successfully applied to the title reaction.
ChemInform Abstract: Ytterbium‐Catalyzed Conjugate Allylation of Alkylidene Malonates.
Authors: Fallan Charlene , Quigley Paul F. , Lam Hon Wei
Published: July 2011

Conjugate allylation with allylstannanes and allylsilanes affords products like (III), (V), (VII) and (IX).
ChemInform Abstract: A Novel and Convenient Synthesis of Benzonitriles: Electrophilic Cyanation of Aryl and Heteroaryl Bromides.
Authors: Anbarasan Pazhamalai , Neumann Helfried , Beller Matthias
Published: July 2011

N‐Cyano‐N‐phenyltosylamide (II) is successfully applied in the electrophilic cyanation of a wide diversity of in situ generated aryl and hetaryl Grignard reagents.
ChemInform Abstract: Development of a Practical Synthetic Method for N‐tert‐Butoxycarbonyl α‐Ketimino Esters.
Authors: Hashimoto Takuya , Yamamoto Kumiko , Maruoka Keiji
Published: July 2011

An operationally simple procedure for the synthesis of the title compounds (III) is presented.
ChemInform Abstract: Synthesis and Catalytic Properties of a Heterocyclic—Carbene Complex of Palladium.
Authors: Shi Yanhui , Cai Zhengyuan , Peng Yu , Shi Zhan , Pang Guangsheng
Published: July 2011

The complex is catalytically highly active in the cross‐coupling reaction of phenyl halides (I) with phenylthiol.
ChemInform Abstract: FeF3/I2‐Catalyzed Synthesis of 4‐Chalcogen‐Substituted Arylamines by Direct Thiolation of an Arene C—H Bond.
Authors: Fang Xiao‐Li , Tang Ri‐Yuan , Zhang Xing‐Guo , Li Jin‐Heng
Published: July 2011

The novel catalytic system is efficient for the electrophilic thiolation of anilines and arenes with similar reactivity.
ChemInform Abstract: Copper‐Mediated Fluoroalkylation Reactions with [(Phenylsulfonyl)difluoromethyl]trimethylsilane: Synthesis of PhSO2CF2‐Containing Allenes and Alkynes.
Authors: Zhu Jieming , Wang Fei , Huang Weizhou , Zhao Yanchuan , Ye Wenchao , Hu Jinbo
Published: July 2011

The new Ph‐SO2‐CF2Cu species, formed in situ from starting compound (I) under conditions A, undergoes cross‐coupling reactions with propargyl chlorides (II) and alkynyl iodides (IV) to afford phenylsulfonyldifluoromethyl‐containing allenes (III) and alkynes (V), respectively.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Intermolecular Stetter Reactions of Acetaldehyde.
Authors: Kim Sun Min , Jin Ming Yu , Kim Mi Jin , Cui Yan , Kim Young Sug , Zhang Liqiu , Song Choong Eui , Ryu Do Hyun , Yang Jung Woon
Published: July 2011

The reaction of various Michael acceptors with acetaldehyde as a complementary method to the enzymatic generation of an acylanion is developed.
ChemInform Abstract: Synthesis of Benzo‐ and Naphtho‐Fused Bicyclo[n.3.1]alkane Frameworks with a Bridgehead Nitrogen Function by Palladium‐Catalyzed Intramolecular α′‐Arylation of α‐Nitroketones.
Authors: Giorgi Giorgio , Maiti Swarupananda , Lopez‐Alvarado Pilar , Menendez J. Carlos
Published: July 2011

DBU‐promoted alkylation of cyclic α‐nitroketones (I) with o‐bromobenzyl halides, e.g. (II), (V) or (VIII), followed by Pd‐catalyzed intramolecular C‐arylation provides an efficient access towards benzo‐fused bicyclo[n.3.1]alkane derivatives (III), (VI) and (IX), respectively.
ChemInform Abstract: Diastereoselective Synthesis of 3‐Hydroxyindanones via N‐Heterocyclic Carbene Catalyzed [4 + 1] Annulation of Phthalaldehyde and 1,2‐Diactivated Michael Acceptors.
Authors: Sun Fang‐Gang , Ye Song
Published: July 2011

The in situ prepared thiazolium N‐heterocyclic carbene catalyzes the tandem reaction of phthalaldehyde (I) with Michael acceptors (II).
ChemInform Abstract: SNAr Reaction of 2,5‐Dinitrofuran: A Mild and Efficient Method for the Preparation of 2‐Aryloxy‐5‐nitrofuran.
Authors: Gavade Sandip , Padiya Kamlesh , Bajare Swapnil , Balaskar Ravi , Mane Dhananjay
Published: July 2011

This is the first example of a phase‐transfer catalyzed SNAr reaction of 2,5‐dinitrofuran.
ChemInform Abstract: A Novel Enzymatic Tandem Process: Utilization of Biocatalytic Promiscuity for High Stereoselective Synthesis of 5‐Hydroxyimino‐4,5‐dihydrofurans.
Authors: Wu Ming‐Yu , Li Kun , He Ting , Feng Xing‐Wen , Wang Na , Wang Xiao‐Yan , Yu Xiao‐Qi
Published: July 2011

PPL‐catalyzed reaction of nitrostyrenes (II) with 1,3‐dicarbonyl compounds (I) and (IV) provides access towards title hydroximino dihydrofurans (III) and (V), resp., in moderate to good yields.
ChemInform Abstract: Iminofuran Chemistry. Part 7. Intramolecular Cyclization of 2‐N‐Aryl‐Substituted Derivatives of 2‐Amino‐4‐aryl‐4‐oxobut‐2‐enoic and 2‐Amino‐5,5‐dimethyl‐4‐oxohex‐2‐enoic Acids.
Authors: Tyuneva A. V. , Igidov N. M. , Koryagina N. N. , Borodin A. Yu. , Zakhmatov A. V. , Makarov A. S. , Toksarova Yu. C. , Rubtsov A. E.
Published: July 2011

All compounds are purified by recrystallization from an aprotic, non‐polar solvent like toluene and hexane.
ChemInform Abstract: Palladium‐Catalyzed Oxidation and Cyclization of Carbon—Carbon Triple Bonds in Fluorous Media Using Molecular Oxygen.
Authors: Wen Yanmei , Zhu Shifa , Jiang Huanfeng , Wang Azhong , Chen Zhenwang
Published: July 2011

Palladium(II) acts as a one‐pot catalyst to promote the oxidation of alkynes (I) with atmospheric oxygen as the sole oxidant in a fluorous biphasic system, followed by a cyclization reaction which results in the direct conversion of alkynes into tetrasubstituted furans (II).
ChemInform Abstract: An Efficient and Clean Michael Addition of Indoles to Electron‐Deficient Olefins under Solvent‐ and Catalyst‐Free Condition.
Authors: Liu Xiong‐Li , Xue Dong , Zhang Zun‐Ting
Published: July 2011

The acidic N‐H proton of indoles (I) plays a key role in the presented Michael addition.