bluuebunny/crossref_metadata_2025 huggingface dataset:
The C-CAP Process: A Comprehensive Approach to Community Resource Mapping
Authors: Mowle Amy , Klepac Bojana , Riley Therese , Craike Melinda
Published: August 2023

Introduction

Place-based systems change approaches are gaining popularity to address the complex problems associated with locational disadvantage. An important stage of place-based systems change involves understanding the context that surrounds (re)produces a target problem. Community resource mapping can be used to establish the context and identify the strengths of a community that might be leveraged through systems change efforts. Approaches to community resource mapping draw on a range of philosophical assumptions and methodological frameworks. However, comprehensive, practical guidance for researchers and practitioners to conduct community resource mapping is scarce.

Method

Drawing on the learnings from a literature review, scoping workshops, and reflective practice sessions, we developed a flexible, methodologically robust process called the Contextualize, Collect, Analyze, and Present (C-CAP) process: a four-phase approach to preparing for, conducting, and reporting on community resource mapping. The C-CAP process was co-developed by researchers and practitioners and was tested and refined in two different communities.

Results

The C-CAP process provides robust guidance for conducting and reporting on a community resource mapping project. The C-CAP process can be applied by public health practitioners and researchers and adapted for use across different communities, problems, and target groups. We encourage others guided by differing theoretical perspectives to apply C-CAP and share the learnings.

Conclusion

Application of the C-CAP process has the potential to improve the comparability and comprehensiveness of findings from community resource mapping projects and avoids duplication of effort by reducing the need to design new processes for each new community resource mapping activity.
Predictors of Return to Work After Thoracic Endovascular Aortic Repair in Patients With Type B Aortic Dissection
Authors: Zou Lingwei , Jiang Xiaolang , Liu Hao , Chen Bin , Jiang Junhao , Ma Tao , Fang Gang , Guo Daqiao , Xu Xin , Fu Weiguo , Dong Zhihui
Published: August 2023

Objective:

Type B aortic dissection (TBAD) is a life-threatening condition, and it takes heavy burden to family and society. Return to work (RTW) not only means patients’ physical health but also demonstrates their mental well-being. Thoracic endovascular aortic repair (TEVAR) has been successful in treatment of TBAD patients. However, less studies have addressed on the social functional recovery of TBAD after TEVAR, especially for RTW.

Methods:

From January 1, 2017 to January 1, 2021, TBAD patients who underwent TEVAR and completed a 12-month follow-up were retrospectively enrolled. Primary outcome was RTW. Patients’ demographic, sociological, and clinical characteristics, and so on were recorded to analyze and demonstrate independent risk factors for RTW.

Results:

Four hundred thirty-two TBAD patients (388 males) were enrolled with a mean age of 48.3±8.9 years (ranged from 19 to 60 years). The 12-month cumulative RTW rate was 62.7% (95% confidence interval [CI]: 57.2%–67.8%). Age <50 years (odds ratio [OR]=3.675, 95% CI: 1.436–9.405) was identified as independent protective factors for RTW, while preoperative job as manual workers (OR=0.101, 95% CI: 0.029–0.353), average annual income, <30 000 Chinese Yuan (CNY) [<4400 US dollar], (OR=0.186, 95% CI: 0.054–0.637), complicated TBAD (malperfusion) (OR=0.246, 95% CI: 0.092–0.659), and distal stent graft-induced new entry (SINE) (OR=0.218, 95% CI: 0.083–0.575, p=0.002) were identified as independent risk factors.

Conclusion:

Approximately 64% of our patients were able to RTW in the 12 months post-TEVAR for TBAD. Younger patients, patients with less physically demanding jobs, and patients with less complex surgeries were more likely to RTW. Based on these results, more can be done to facilitate the patient’s ability and willingness to RTW after TEVAR.

Clinical Impact

Type B aortic dissection (TBAD) is a life-threatening condition that poses significant burden on both individuals and society. The ability to return to work (RTW) not only reflects the patient’s physical health but also indicates their mental well-being. Therefore, identifying risk factors for RTW and promoting the reintegration of TBAD patients into the workforce is crucial in clinical practice.To our knowledge, this study is the first to elucidate and predict the RTW outcomes of TBAD patients who underwent thoracic endovascular aortic repair (TEVAR).
Establishment of a Selective Liver Lobe Tumor-Bearing Mouse Model of Colorectal Cancer
Authors: Han Zheqi , Qiu Biying , Li Lin , Yu Jianhua , Zhu Zhiyang
Published: August 2023

Purpose

Colorectal cancer is one of the most common causes of cancer-related death, and its main site of metastasis is the liver. The surgical method used for metastases of colorectal cancer in the liver varies according to the lobe affected, as does the prognosis. However, there is a lack of relevant basic research. Therefore, a good animal model is needed for basic studies of metastases from colorectal cancer to the different lobes of the liver.

Methods

A CT26 colon cancer cell line transfected with a virus expressing green fluorescent protein was inoculated into BALB/C mice via the spleen. Tumor formation in the liver lobes was observed under a fluorescence microscope according to which portal vein branch was ligated and according to clamping time. The differential formation of metastatic lesions in the different lobes was then compared with physical anatomy. Serum samples were used to detect the changes in liver function postoperatively.

Results

Ligation and resection of the spleen 1 min after injection of the CT26 cells and release of the vessel clamp 1 min after splenectomy created an ideal tumor-bearing mouse model with little effect on liver function. Selective clamping of each portal vein branch and splenic injection of a CT26 cell line successfully established a selective liver lobe tumor-bearing model of colorectal cancer with distinct characteristics.

Conclusion

This model provides an opportunity for investigation of the mechanisms of metastasis of colorectal cancer to different lobes of the liver and may provide a basis for clinical treatment.
Valorization of Baker Yeast Industry Waste in Agriculture by Improving Germination and Growth of Barley and Pea
Authors: Aissani Nadhem , Aissani Rania , Ghidaoui Makrem , Zouidi Ferjeni , Sebai Hichem
Published: August 2023

Industrial waste still present an environmental danger for the nature and survival of all living beings. Among these toxic products, the focus has been on liquid effluents from the baker's yeast industry that cause real environmental problems mainly due to their pollutant load and the release of unpleasant odors. In order to minimize these hazards and to take advantage of these wastes for the sake of our environment, the present work consists on valorizing effluents from the baker's yeast industry on barley ( Hordeum vulgare) and pea ( Pisum sativum), two important agricultural products of Tunisian north-west. Results showed that this waste is characterized by its richness in organic matter, and the presence of proteins traces with high chemical and biochemical oxygen demand (COD and BOD5) values. Diluted effluent at a dose of 2.5 mg/g significantly improves germination of both plant seeds by germination index (GI) calculation, to reach a maximum of 190 ± 17% and 150 ± 14% for barley and pea, respectively. In fertigation experiment, the use of a lower dose of .62 mg/g of diluted effluent promotes plant length to reach 52 ± 4 cm and 45 ± 1.4 cm, respectively, for H. vulgare and P. sativum. Gas chromatography coupled to mass spectrometry (GC-MS) analysis after derivatization showed significant enhancement of auxin production in pea treated with .62 mg/g of cream compared to control with a concentration of 10.60 ± .81 and 8.16 ± .43 ng/gFW, respectively. In another experiment, the irrigation of pea plants with furfural, as major compound of cream, promotes length and auxin production to reach 9.89 ± .56 ng/gFW for a furfural dose of .31 mg/g. This leads us to valorize baker’s yeast effluent as an environment-friendly natural product in pea and barley agricultural and give insight to its mode of action.
The balloon occlusion sheath for stroke (BOSS) balloon guide catheter for stroke intervention: Safety and technical success
Authors: Cuoco Joshua A , Entwistle John J , Siddiq Farhan , Puri Ajit S , Woodward Keith , Hanel Ricardo A , Ansari Sameer A , Frei Donald , Patel Biraj M
Published: August 2023

Background

We describe the first-in-human experience using the Balloon Occlusion Stroke Sheath (BOSSTM) balloon-guide catheter to perform stroke thrombectomy in 50 consecutive patients enrolled in the Flow Arrest Safety and Technical success with balloon-guide catheters trial. This aspiration system includes a novel 9.4F balloon-guide catheter conduit for the insertion and guidance of catheters with a balloon providing temporary flow arrest.

Methods

The Flow Arrest Safety and Technical success with balloon-guide catheter trial is a single-arm, prospective, multi-center, non-randomized, observational registry evaluating the use of the market-released BOSSTM balloon-guide catheter in adult patients diagnosed with an acute ischemic stroke attributable to large vessel occlusion. The purpose of the current trial was to assess the safety and technical success associated with the use of the BOSSTM balloon-guide catheter.

Results

Fifty patients met inclusion criteria with a mean baseline National Institutes of Health Stroke Scale (NIHSS) of 16. Treatment devices, including aspiration and stent retriever devices, were used in a total of 88 passes. The BOSSTM balloon-guide catheter was compatible with all stroke thrombectomy treatment devices used in 98% (49/50) of procedures. Balloon inflation and flow arrest were achieved in 100% (50/50) and 98% (49/50) of cases, respectively. Balloon deflation and retraction were observed in 100% (50/50) of cases. Successful reperfusion (modified thrombolysis in cerebral infarction score > 2b) was achieved in 100% of cases with single-pass reperfusion achieved in 62% (31/50) of cases.

Conclusions

The BOSSTM balloon-guide catheter is a safe and technically effective adjunctive device for mechanical thrombectomy of acute ischemic stroke due to large vessel occlusion.
Lidocaine for headache prevention during chronic subdural hematoma embolization
Authors: Diana Francesco , Romoli Michele , Ricchetti Francesca , Milonia Luca , Salcuni Andrea , Cirelli Carlo , Ruzza Alberto Di , Gaudino Chiara , Iacobucci Marta , Biraschi Francesco
Published: August 2023

Background

Middle meningeal artery embolization (MMAE) for the management of chronic subdural hematomas (CSDH) with ethylene vinyl alcohol (EVOH) causes an evident patient discomfort due to meningeal nociceptors stimulation. The aim of this study was to assess safety and efficacy of intra-arterial lidocaine (IAL) before MMAE of CSDH with EVOH.

Methods

We analyzed all consecutive patients with bilateral CSDH undergoing MMAE with EVOH. We used a monolateral IAL injection, with casual allocation. We assessed the headache felt by patients during embolization with the visual analog scale (VAS) and compared scores obtained after embolization of both sides. We followed the STROBE guidelines for case–control studies. Paired t-test and χ2 test were used to compare the distribution of variables in IAL vs control group.

Results

Between September 2021 and March 2023, 32 patients underwent bilateral MMAE with EVOH for a CSDH. Lidocaine treatment resulted in a substantially lower VAS score compared to the control group (median 3 vs 7, p < 0.001), with no substantial side effect. Compliance also benefited from lidocaine administration.

Conclusions

In patients with CSDH undergoing MMAE, IAL seems to reduce pain sensation associated with EVOH injection and to increase patients’ compliance during treatment.
SUBTLEX-CY: A new word frequency database for Welsh
Authors: van Heuven Walter JB , Payne Joshua S , Jones Manon W
Published: August 2023

We present SUBTLEX-CY, a new word frequency database created from a 32-million-word corpus of Welsh television subtitles. An experiment comprising a lexical decision task examined SUBTLEX-CY frequency estimates against words with inconsistent frequencies in a much smaller Welsh corpus that is often used by researchers, the Cronfa Electroneg o’r Gymraeg (CEG), and three other Welsh word frequency databases. Words were selected that were classified as low frequency (LF) in SUBTLEX-CY and high frequency (HF) in CEG and compared with words that were classified as medium frequency (MF) in both SUBTLEX-CY and CEG. Reaction time analyses showed that HF words in CEG were responded to more slowly compared to MF words, suggesting that SUBTLEX-CY corpus provides a more reliable estimate of Welsh word frequencies. The new Welsh word frequency database that also includes part-of-speech, contextual diversity, and other lexical information is freely available for research purposes on the Open Science Framework repository at https://osf.io/9gkqm/ .
Planning to conceive within a year is associated with better pregnancy-specific disease-related patient knowledge and better medication adherence in women of childbearing age with inflammatory bowel disease
Authors: Selinger Christian P. , Laube Robyn , Steed Helen , Brookes Matthew , BioResource NIHR , Leong Rupert W. L.
Published: August 2023

Background:

Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy.

Objective:

To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence.

Design:

Cross-sectional survey study

Methods:

We surveyed female patients with IBD aged 18–35 years, who at recruitment to the UK IBD BioResource had not had children. We elicited disease and treatment history, demographics and family planning status via an online questionnaire . Patient knowledge as assessed by the validated Crohn’s and Colitis Pregnancy Knowledge Score (CCPKnow) and adherence by visual analogue scale (VAS).

Results:

In 326 responders (13.8% response rate), good adherence (VAS ⩾ 80) was found in only 38.35%. Disease- and treatment-related factors were not significantly associated with good adherence, except for methotrexate (70.0% adherent of 10 exposed patients versus 37.2% non-exposed; p = 0.036). Patients planning pregnancy for the next year were more often adherent (59.0% versus 35.5%; p = 0.019) and knowledgeable (median CCPKnow 8 versus 7; p = 0.035) compared to those in other family planning categories. Pregnancy-related patient knowledge was significantly associated with adherence (Pearson correlation 0.141; p = 0.015). Adherent patients had significantly higher CCPKnow scores than non-adherent patients (median 8 versus 6; p = 0.009). On binary regression analysis, only planning to conceive within 12 months was independently associated with better adherence ( p = 0.016), but not methotrexate exposure ( p = 0.076) and CCPKnow ( p = 0.056).

Conclusions:

In a cohort of women of childbearing age with IBD overall medication, adherence was low. Planning to conceive within the next year was associated with better adherence and greater patient knowledge.
Atezolizumab-induced subacute cerebellar ataxia in a patient with extensive-stage small cell lung cancer
Authors: Chen Chun-Chia , Tseng Kuan-Hua , Lai Kuan-Lin , Chiang Chi-Lu
Published: August 2023

Recently, immune checkpoint inhibitors (ICIs) have become the standard treatment option for patients with lung cancer, including small cell lung cancer (SCLC). ICI-induced neurological immune-related adverse events are rare and exhibit diverse clinical manifestations, often leading to missed or delayed diagnosis. Herein, we report the case of a patient with extensive-stage SCLC who received atezolizumab with etoposide/platinum and gradually developed neurological symptoms after three cycles of chemoimmunotherapy. Subsequently, the patient received a diagnosis of subacute immune-related cerebellar ataxia and was treated successfully with pulse steroid therapy. The patient exhibited almost complete remission of neurological symptoms and had progression-free survival for >24 months.
Impact of the coronavirus disease 2019 pandemic on sarcoma management in France: a 2019 and 2020 comparison
Authors: Penel Nicolas , Cantarel Coralie , Chemin-Airiau Claire , Ducimetiere Françoise , Gouin François , Le Loarer François , Toulmonde Maud , Piperno-Neumann Sophie , Bellera Carine , Honore Charles , Blay Jean-Yves , Mathoulin-Pelissier Simone
Published: August 2023

Background:

The coronavirus disease 2019 (COVID-19) pandemic was an unprecedented shock to the healthcare systems, and its consequences on managing rare cancers are unknown. We investigated COVID-19’s impact on the activity of sarcoma-labeled networks by comparing key indicators in 2019–2020 (before and during the pandemic, respectively).

Methods:

We compared the incidence of limb and trunk soft tissue sarcomas, surgery rate, surgery center, surgery quality, and surgery delays nationally and in various regions, focusing on the three most severely affected regions.

Findings:

In this study, sarcoma incidence did not decrease, and the tumor and patient characteristics were similar in both years. The number of patients who underwent surgery in the labeled centers increased significantly (63% versus 57%, p = 0.015), the rate of R0 resection increased (55% versus 47%, p = 0.004), and the rate of re-excision decreased (12% versus 21%, p < 0.0001). In the univariate analysis, the time to surgery was similar in both years. Cox regression analysis revealed that the factors associated with a longer time to surgery were age > 70 years ( p = 0.003), retroperitoneal location ( p > 0.001), tumor size ( p < 0.001), deep tumors ( p < 0.001), and regions ( p < 0.001). However, we have observed an increase in the time before surgery in the regions most stroked by the COVID-19 pandemic.

Interpretation:

The model of the labeled center network for managing rare tumors was resilient. Paradoxically, the quality indicators improved during the pandemic due to the direct referral of patients with sarcomas to the labeled centers.

This study shows that a nationwide network organization has made it possible to maintain care for these rare tumors during the pandemic.
Il-1β Promotes Superficial Zone Cells Senescence in Articular Cartilage by Inhibiting Autophagy
Authors: Xu Wei , Wang Juan , Cui Lin , Huang Chen , Xia Ning , Xie Meiming , Liu Da , Liao Dongfa
Published: August 2023

Objective

The superficial zone cells in articular cartilage (SFZCs) have been identified as stem/progenitor chondrocytes and promoted cell self-renewal in the osteoarthritis (OA). Several studies emphasized the involvement of senescence and autophagy in OA. Interleukin-1β (IL-1β) is one of the main inflammatory mediators of OA, and whether it induces senescence and autophagy in SFZCs remains unclear. The present study aimed to investigate autophagy flux, mitochondrial function, and intracellular reactive oxygen species (ROS) that resulted in senescence in SFZCs induced by IL-1β.

Methods

Using western blotting, reverse transcription-quantitative PCR, immunofluorescence, intracellular ROS detection, mitochondrial staining, and determination of mitochondrial membrane potential, we tested senescence and autophagy markers in SFZCs induced by IL-1β in vitro. The consequences of mitochondrial function and ROS were also studied with IL-1β-induced senescence.

Results

IL-1β treatment decreased SFZC proliferation, induced SFZC senescence, and reduced SFZCs’ chondrogenic differentiation capacity. Moreover, IL-1β impaired autophagy flux, and the autophagy activator, rapamycin, attenuated the senescence of SFZCs. IL-1β-induced autophagy defect resulted in mitochondrial dysfunction and overproduction of ROS, and autophagy activation notably protected against mitochondrial dysfunction and reduced the levels of ROS. Moreover, antioxidant N-acetylcysteine reversed the senescence of IL-1β in SFZCs.

Conclusion

IL-1β promotes autophagy impairment and subsequently results in dysfunctional mitochondria and overproduction of ROS, which finally causes SFZC senescence.
Antineutrophil cytoplasmic antibody-associated vasculitis predominantly manifesting tubulointerstitial nephritis: A case report
Authors: Nishioka Ken , Yamaguchi Shintaro , Hashiguchi Akinori , Yoshimoto Norifumi , Tajima Takaya , Yasuda Itaru , Uchiyama Kiyotaka , Kaneko Kenji , Aso Mitsuhiro , Yoshino Jun , Monkawa Toshiaki , Kanda Takeshi , Hayashi Kaori , Itoh Hiroshi
Published: August 2023

The common histopathology of antineutrophil cytoplasmic antibody-associated vasculitis comprises pauci-immune crescentic glomerulonephritis with concomitant tubulointerstitial nephritis. Tubulointerstitial nephritis in the absence of glomerular involvement in patients with antineutrophil cytoplasmic antibody-associated vasculitis is uncommon. We report a case of antineutrophil cytoplasmic antibody-associated vasculitis-associated acute kidney injury manifesting as tubulointerstitial nephritis without glomerulonephritis. A 75-year-old woman with fever, cough, and myalgia developed kidney dysfunction with inflammatory reactions and tubular-type proteinuria, without glomerular hematuria. A kidney biopsy revealed tubulointerstitial nephritis with arteritis. We ruled out important underlying etiologies of tubulointerstitial nephritis, including infection, drug reactions, and autoimmune diseases. Since chest high-resolution computed tomography demonstrated mild interstitial pneumonia in bilateral lower lung fields, myeloperoxidase antineutrophil cytoplasmic antibody was measured and found to be positive. Therefore, we diagnosed the patient with antineutrophil cytoplasmic antibody-associated vasculitis-associated tubulointerstitial nephritis but not glomerulonephritis, and interstitial pneumonia. The patient’s kidney function and symptoms markedly improved with prednisolone treatment. Clinicians should maintain high-level vigilance for antineutrophil cytoplasmic antibody-associated vasculitis as a possible underlying component of tubulointerstitial nephritis, particularly when kidney function deteriorates with tubulointerstitial injuries without glomerular features.
Understanding the impact of digital technology on the well-being of older immigrants and refugees: A scoping review
Authors: Ekoh Prince Chiagozie , Okolie Tochukwu Jonathan , Nnadi Fidel Bethel , Oyinlola Oluwagbemiga , Walsh Christine A
Published: August 2023

Background

The fast-paced development of digital technologies in the areas of social media, pet robots, smart homes, and artificial intelligence, among others, profoundly influence the daily lives of older adults. Digital technology can improve the well-being and quality of life of older adults, older immigrants and refugees who suffer migration-associated stress, loneliness, health and psychosocial challenges.

Aims

The aim of this scoping review is to map out extant empirical literature that has examined the implication of digital technology among older refugees and immigrants.

Methods

Using a 1 five-stage framework, we conducted a scoping review of peer-reviewed empirical studies published in English with no time restrictions. We searched nine databases for the reviews, and abstracts were reviewed using Rayyan QCRi(c) before the full-text review. The comprehensive database search yielded 4134 articles, of which 15 met the inclusion criteria.

Results

The results of the review suggest that digital technology is essential to the well-being, quality of life of older immigrants and refugees, especially for maintaining and building new social support networks, navigating opportunities, coping with migration-induced stress through e-leisure, and staying connected to their culture. The literature also revealed poor utilisation of digital technologies amongst older immigrants and refugees, suggesting barriers to access.

Conclusion

The study concluded by highlighting the need for more research and interventions that focus on multiple strategies, including education for increased access to and utilisation of digital technology to ensure that more older migrants can benefit from the advantages of digital technology in a safe way.
Diagnostic validation of smart wearable device embedded with single-lead electrocardiogram for arrhythmia detection
Authors: Niu Yonghong , Wang Hao , Wang Hong , Zhang Hui , Jin Zhigeng , Guo Yutao
Published: August 2023

Objective

To validate a single-lead electrocardiogram algorithm for identifying atrial fibrillation, atrial premature beats, ventricular premature beats, and sinus rhythm.

Methods

A total of 656 subjects aged 19 to 94 years were enrolled. Participants were simultaneously tested with a wristwatch (Huawei Watch GT2 Pro, Huawei Technologies Co., Ltd, Shenzhen, China) and a 12-lead electrocardiogram for 3 minutes. A total of 1926 electrocardiogram signals from 628 subjects (282 men and 346 women) aged 19 to 94 years (median 64 years) were analyzed using an algorithm.

Results

The numbers of subjects with atrial fibrillation, atrial premature beats, ventricular premature beats, and sinus rhythm were 129, 141, 107, and 251, respectively, and together they had a total of 1926 electrocardiogram signals. For the three-class classification system, the recall, precision, and F1 score were 97.6%, 96.5%, 97.0% for sinus rhythm; 96.7%, 96.9%, 96.8% for atrial fibrillation; and 92.8%, 94.2%, 93.5% for ectopic beats, respectively. The macro-F1 score of the three-class classification system was 95.8%. For the four-class classification system, the recall, precision, and F1 score were 97.6%, 96.5%, 97.0% for sinus rhythm; 96.7%, 96.9%, 96.8% for atrial fibrillation; 90.5%, 89.4%, 89.9% for atrial premature beats; and 86.1%, 89.6%, 87.8% for ventricular premature beats, respectively. The macro-F1 score of the four-class classification system was 92.9%.

Conclusions

The single-lead electrocardiogram algorithm embedded into smart wearables demonstrated good performance in detecting atrial fibrillation, atrial/ventricular premature beats, and sinus rhythm, and thus would facilitate atrial fibrillation screening and management.
Bringing Bourdieu to a Content Farm: Social Media Production Fields and the Cultural Economy of Attention
Authors: Mears Ashley
Published: August 2023

Attention is a valuable and scarce resource in the online “attention economy.” But not all attention is equally valuable. This article advances a relational theory of the value of attention by situating social media content production as a field. I draw from an ethnography of a “content farm” and interviews with 60 creators who make highly-paid but low-status entertainment videos designed to go viral on Facebook, as well as on SnapChat, TikTok, and YouTube. I propose an inverse relationship between status and reach: higher reach may pose risks to a creator’s status and reputation. Furthermore, in pursuit of the highest possible reach, viral creators construct situational authenticity, rather than personal authenticity, and they relate to their audiences antagonistically, in contrast to existing studies of influencers. How creators seek attention, from whom, and with what conversion strategies, I argue, depends upon their location in a cultural field because online audiences exist in a hierarchy of perceived social worth.
Semantic Search Engine Optimization in the News Media Industry: Challenges and Impact on Media Outlets and Journalism Practice in Greece
Authors: Giomelakis Dimitrios
Published: August 2023

In today’s digital media environment, search engines constitute a significant gateway to news and an important source of traffic for online news outlets worldwide, identifying the significance of top rankings in search results. In this context, search engine optimization (SEO) has entered newsrooms as an essential element of disseminating the content of online media organizations, creating new practices and challenges for media professionals. However, the transition to the Semantic Web (SW) and the development of major search engines in recent years have led to the emergence of Semantic SEO as a new approach to old SEO practices, creating at the same time new challenges for the news media industry. This study investigates the application of Semantic SEO inside newsrooms and its impact on journalism and news media organizations. Drawing upon a series of semi-structured interviews with Greek SEO experts and a systematic review of the notion of semantic search and the corresponding semantic SEO technologies, the objective of this work is to present an analysis of how Semantic SEO affects news media and journalism content as well as to identify some of the technological practices that could contribute to enhancing the discoverability of news content in the changing context of online search.
Spotlighting the probation meeting – Lived experiences of desistance-supporting interaction following imprisonment
Authors: Koffeld-Hamidane Sylvia , Andvig Ellen , Karlsson Bengt
Published: August 2023

Probation staff in Norway are responsible for implementing the continuation of sentences following imprisonment, such as in drug rehabilitation institutions, electronic monitoring, home detention, and early release on parole. The Norwegian Correctional Service aims to support positive change and provide training in change-focused dialogue. However, little is known about the content of meetings between formerly imprisoned persons and probation staff following imprisonment. Our analysis is based on 19 interviews conducted within the first year after release or transition from prison to the community and highlights the participants’ lived experiences of these meetings. We show their perceptions of the value of this dialogue, especially as it delves into the circumstances contributing to the offence, how the offence affects their self-concept and challenging barriers to approaching society. This interaction often developed within sustained relationships. Despite this, some were disappointed with a discrepancy between their longing for help and their experience of control practices. We elaborate on how the interaction facilitates and frustrates desistance processes during resettlement.
The Influence of Performance Appraisal Justice on Employee Job Performance: A Dual Path Model
Authors: Lyu Bei , Su Weilin , Qi Qian , Xiao Fujun
Published: August 2023

Performance appraisal, as a powerful tool for human resource management, has become an important driving force for organizations to achieve sustainability. However, only when employees believe that a performance appraisal is fair can an organization’s performance appraisal truly work and have a positive impact on employees. Hence, based on social exchange theory and social identity theory, we theorized and validated a dual path model to explore the influence of performance appraisal justice on employee job performance through work engagement and organizational identification. Survey data from 404 Chinese employees and their direct supervisors in high-tech enterprises were analyzed using multiple regression and structural equation modeling. Results indicate that performance appraisal justice of employees has a positive impact on their work engagement, organizational identification, and job performance. In addition, both work engagement and organizational identification of employees partly mediated the relationship between performance appraisal justice and their job performance. Our conclusions mean that when employees perceive justice in organizational performance appraisals, they will actively engage in their daily work and truly identify with their organizations, thus improving job performance, which is conducive to the sustainable development of organizations. The limitations and implications for future research and practice are also discussed.
Exploring Tourist Behavior in Active Sports Tourism: An Analysis of the Mediating Role of Emotions and Moderating Role of Surfing Identification
Authors: Jeong Yunduk
Published: August 2023

Despite increased attention toward sports tourist experiences, the concept of natural soundscapes and memorable tourism experience (MTE) are under-researched topics of study in sports tourism literature. This study explores the structural relationship between natural soundscapes, MTE, emotions, and destination loyalty in the context of active sports tourism. Furthermore, it investigates the mediating effects of emotions between “natural soundscapes and destination loyalty” and “MTE and destination loyalty” and examines the moderating effects of surfing identification on the relationships between “natural soundscapes and destination loyalty,”“MTE and destination loyalty,” and “emotions and destination loyalty.” The results indicate that there is a positive impact of (a) natural soundscapes on emotions and destination loyalty, (b) MTE on emotions and destination loyalty, and (c) emotions on destination loyalty. Moreover, emotions were found to partially mediate the aforementioned relationships and surfing identification moderated the aforementioned paths. Positioning natural soundscapes as a novel active sports tourism attractor and emphasizing the importance of MTE and emotions as important antecedents of sporting destination loyalty, when sports tourists were interested and partook physically and actively in sports, the aforementioned relationships were stronger. This study presents the theoretical and managerial implications of these results.
Impressionable Years and Trust in Institutions: Microeconomic Evidence from Argentina
Authors: González Fernando Antonio Ignacio , Simes Horacio
Published: August 2023

In this study, we analyse the existence of critical periods in the formation of beliefs and attitudes. We explore the hypothesis of impressionable years (18–25) about having experienced a major macroeconomic crisis and its persistent consequences on trust in institutions. Based on microdata from a recent opinion survey, the regression analysis exploits the differential effect of a major Argentine economic crisis (2001–2002) on different cohorts. We include province fixed effects, age dummies, and other economic and demographic controls. We consider different placebos tests and robustness checks to rule out potential limitations in the estimates. The results suggest that young adults who experienced a major macroeconomic crisis express, almost two decades after the event, a lower trust in political institutions, including the National Congress and the Supreme Court, and a greater perception of corruption among public officials.
Surgical Correction of Aneurysmal Dilatation in a Coronary Cameral Fistula: A Case Report
Authors: Sajja Lokeswara Rao , Dandu Satya Bhaskara R. , Mannam Gopichand , Kamtam Devanish Narasimhasanth
Published: August 2023

Coronary cameral fistula (CCF) is an uncommon congenital anomaly that is typically discovered incidentally or may manifest with symptoms of angina. We present a case of CCF originating from the right coronary artery (RCA) and extending to the main pulmonary artery (MPA), characterized by aneurysmal dilatation at the pulmonary artery end. The patient presented with angina and exhibited ischemic changes in the inferior leads on electrocardiography. Additionally, the patient had coexisting stenosis of the left anterior descending artery (LAD). Consequently, the patient underwent a successful surgical closure of the fistula, along with surgical revascularization of the LAD.
Decision Making in Combined Hip Arthroscopy and Femoral Derotational Osteotomy Surgeries
Authors: Steiner Quinn , Zacharias Anthony J. , Goodspeed David C. , Spiker Andrea M.
Published: August 2023

Background:

Femoral version abnormalities can contribute to intra-articular hip pathology. Combined hip arthroscopy with femoral derotational osteotomy (FDRO) has been shown to successfully treat those with intra-articular hip pathology with excessive anteversion or retroversion of the femur.

Indications:

We describe the technique for combined hip arthroscopy and FDRO in patients with symptomatic intra-articular hip pathology in the setting of excessive anteversion or retroversion of the femur.

Technique Description:

Hip arthroscopy is performed using standard anterolateral, modified mid-anterior, and distal anterolateral accessory portals. The labrum is repaired using a narrow diameter suture. Femoroplasty is performed with utilization of fluoroscopic imaging to assess resection. Dynamic flexion is performed as a final check of adequacy of resection. Capsular closure is performed in all cases. After hip arthroscopy, the patient is repositioned on a radiolucent table. A piriformis start point is obtained with a guide pin followed by standard opening reaming and ball-tipped guidewire placement. A femoral osteotomy is made just proximal to the isthmus and made through a lateral approach to the femur. Two K-wires are placed distal and proximal to the osteotomy site. A goniometer is then used to measure rotation. A drill is used to perforate the cortex circumferentially at the osteotomy site. After standard reaming, a sagittal saw is then used to start the osteotomy cut followed by an osteotome. An intramedullary nail is inserted over a ball-tipped guidewire while rotational reduction is assessed from the foot of the operating table. Distal interlocking screws are placed, and the nail is backslapped to create compression at the osteotomy site prior to placing proximal interlocking screws.

Results:

Recent studies show improved hip outcome scores in patients who undergo concomitant hip arthroscopy and FDRO for symptomatic abnormal femoral version.

Discussion/Conclusion:

Identifying patients who would benefit from concomitant surgeries requires thorough preoperative evaluation. Correct identification and treatment of these patients leads to improved outcomes.

Patient Consent Disclosure Statement:

The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Productivity in Projects: Adjusting Project-Based Learning for Students With Autism
Authors: Tofte Michelle A. , Andzik Natalie R.
Published: August 2023

Although teacher-centered instruction is common, there is evidence suggesting an increased level of motivation and engagement among students when their preferences are considered. As such, teachers are beginning to shift their instructional practices, which can be exceptionally challenging in an inclusive classroom, especially when supporting students with autism. Project-Based Learning (PjBL) is an innovative approach that promotes life skills through inquiry, research, collaboration, and the creation of projects. Although integrating students with autism within an active participation model like PjBL can be challenging, educators can use evidence-based practices to promote a positive classroom climate that fosters the learning of all students.
Who cares about migraine? Pathways and hurdles in the European region - access to care III
Authors: Vaghi Gloria , De Icco Roberto , Tassorelli Cristina , Goadsby Peter J. , Vicente-Herrero Teófila , de la Torre Elena Ruiz
Published: August 2023

Background

Migraine is a highly prevalent primary headache disorder and a leading cause of disability. Difficulties in access to care during diagnostic and therapeutic journey contribute to the disease burden. Several target-specific drugs have reached the market in the past four years and have modified the treatment paradigm in migraine. The aim of this study is to provide an updated snapshot of the pathways and hurdles to care for migraine in different European countries by directly asking patients.

Methods

In 2021 the European Migraine and Headache Alliance proposed a 39-item questionnaire that was administered online to an adult migraine population in European countries. Questions were focused on socio-demographic and migraine data, access to diagnosis and treatment, disease-related burden and the main channel for disease information.

Results

A total of 3169 questionnaires were returned from 10 European countries. Responders were predominantly females, age range 25–59 years, with a migraine history longer than 10 years in 82% of cases, and with at least 8 headache days per month in 57% of cases. Respondents reported limitations in social, working and personal life during both the ictal and interictal phase. The activities mostly impaired during the attacks were driving (55%), cooking or eating (42%), taking care of family/childcare (40%) and getting medicines at the pharmacy (40%). The most frequently reported unmet need was the long delay between the first visit and migraine diagnosis: 34% of respondents had to see ≥ 4 specialists before being correctly diagnosed, and between the diagnosis and treatment prescription: > 5 years in 40% of cases. The most relevant needs in terms of quality of life were the desire for a lower migraine frequency, an effective treatment and a greater involvement in society.

Conclusions

Data from the present survey point to the existence and persistence of multiple hurdles that result in significant limitations to access to care and to the patients’ social life. A close cooperation between decision makers, healthcare workers and patients is needed to overcome these barriers.

Graphical Abstract
Status of diagnosis and preventative treatment for primary headache disorders: real-world data of unmet needs in China
Authors: Liu Huanxian , Dong Ming , Liu Kaiming , Jia Zhihua , Gui Wei , Cheng Yingying , Lv Yudan , Qu Kang , Zhao Hongru , Chen Jianjun , Zhang Dan , Fan Zhiliang , Yang Xiaosu , Hu Dongmei , Xie Hongyan , Li Mingxin , Wen Bing , Chen Sufen , Xu Peng , Rong Qingqing , He Qiu , Ren Zhanxiu , Yan Fanhong , Zhao Heling , Chen Min , Yu Tingmin , Qu Hongli , An Xingkai , Guo Huailian , Zhang Xinhua , Pan Xiaoping , Wang Xiaojuan , Qiu Shi , Zhang Lvming , Zhao Hongling , Pan Xin , Wan Qi , Yan Lanyun , Liu Jing , Yu Zhe , Zhang Mingjie , Ran Ye , Han Xun , Yu Shengyuan , Dong Zhao
Published: August 2023

Background

Headache disorders are widely prevalent and pose a considerable economic burden on individuals and society. Globally, misdiagnosis and inadequate treatment of primary headache disorders remain significant challenges, impeding the effective management of such conditions. Despite advancements in headache management over the last decade, a need for comprehensive evaluations of the status of primary headache disorders in China regarding diagnosis and preventative treatments persists.

Methods

In the present study, we analyzed the established queries in the Survey of Fibromyalgia Comorbidity with Headache (SEARCH), focusing on previous diagnoses and preventative treatment regimens for primary headache disorders. This cross-sectional study encompassed adults diagnosed with primary headache disorders who sought treatment at 23 hospitals across China between September 2020 to May 2021.

Results

The study comprised 2,868 participants who were systematically examined. Migraine and tension-type headaches (TTH) constituted a majority of the primary headache disorders, accounting for 74.1% (2,124/2,868) and 23.3% (668/2,868) of the participants, respectively. Medication overuse headache (MOH) affected 8.1% (231/2,868) of individuals with primary headache disorders. Over half of the individuals with primary headache disorders (56.6%, 1,624/2,868) remained undiagnosed. The previously correct diagnosis rates for migraine, TTH, TACs, and MOH were 27.3% (580/2,124), 8.1% (54/668), 23.2% (13/56), and 3.5% (8/231), respectively. The misdiagnosis of “Nervous headache” was found to be the most prevalent among individuals with migraine (9.9%, 211/2,124), TTH (10.0%, 67/668), trigeminal autonomic cephalalgias (TACs) (17.9%, 10/56), and other primary headache disorders (10.0%, 2/20) respectively. Only a minor proportion of individuals with migraine (16.5%, 77/468) and TTH (4.7%, 2/43) had received preventive medication before participating in the study.

Conclusions

While there has been progress made in the rate of correct diagnosis of primary headache disorders in China compared to a decade ago, the prevalence of misdiagnosis and inadequate treatment of primary headaches remains a veritable issue. As such, focused efforts are essential to augment the diagnosis and preventive treatment measures related to primary headache disorders in the future.
Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort
Authors: He Quanfa , Keding Taylor J. , Zhang Qi , Miao Jiacheng , Russell Justin D. , Herringa Ryan J. , Lu Qiongshi , Travers Brittany G. , Li James J.
Published: August 2023

Background

ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typicallycorrelatedwith ADHD but not necessarily reflective ofcausalmechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes.

Methods

Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs—one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e.,AnnoPred)—on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe.

Results

A direct effect was detected between theAnnoPredADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC.

Conclusions

TheAnnoPredADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional orAnnoPredADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures.
Non-canonical transcriptional start sites in E. coli O157:H7 EDL933 are regulated and appear in surprisingly high numbers
Authors: Zehentner Barbara , Scherer Siegfried , Neuhaus Klaus
Published: August 2023

Analysis of genome wide transcription start sites (TSSs) revealed an unexpected complexity since not only canonical TSS of annotated genes are recognized by RNA polymerase. Non-canonical TSS were detected antisense to, or within, annotated genes as well new intergenic (orphan) TSS, not associated with known genes. Previously, it was hypothesized that many such signals represent noise or pervasive transcription, not associated with a biological function. Here, a modified Cappable-seq protocol allows determining the primary transcriptome of the enterohemorrhagic E. coli O157:H7 EDL933 (EHEC). We used four different growth media, both in exponential and stationary growth phase, replicated each thrice. This yielded 19,975 EHEC canonical and non-canonical TSS, which reproducibly occurring in three biological replicates. This questions the hypothesis of experimental noise or pervasive transcription. Accordingly, conserved promoter motifs were found upstream indicating proper TSSs. More than 50% of 5,567 canonical and between 32% and 47% of 10,355 non-canonical TSS were differentially expressed in different media and growth phases, providing evidence for a potential biological function also of non-canonical TSS. Thus, reproducible and environmentally regulated expression suggests that a substantial number of the non-canonical TSSs may be of unknown function rather than being the result of noise or pervasive transcription.