bluuebunny/crossref_metadata_2025 huggingface dataset:
Figures S1-S9, Tables S1-S5, Appendices 2-4 Data Supplementary1 from Apalutamide and Goserelin for Androgen Receptor–Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU
Authors: Honma Yoshitaka , Monden Nobuya , Yamazaki Keisuke , Kano Satoshi , Satake Hironaga , Kadowaki Shigenori , Utsumi Yoshitaka , Nakatogawa Tomohiko , Takano Ryo , Fujii Koji , Koroki Yosuke , Aoyama Junya , Ouchi Shohei , Ogawa Tetsuro , McCarthy Sharon , Brookman-May Sabine D. , Mundle Suneel , Li Jinhui , Thaper Daksh , Nagao Toshitaka , Tada Yuichiro
Published: August 2024

Supplementary Materials for Apalutamide and Goserelin for Androgen Receptor-Positive Salivary Gland Carcinoma: A Phase 2 Nonrandomized Clinical Trial, YATAGARASU
Trametinib Potentiates Anti-PD-1 Efficacy in Tumors Established from Chemotherapy-Primed Pancreatic Cancer Cells
Authors: Pham Thao D. , Metropulos Anastasia E. , Mubin Nida , Becker Jeffrey H. , Shah Dhavan , Spaulding Christina , Shields Mario A. , Bentrem David J. , Munshi Hidayatullah G.
Published: August 2024

Despite advances in immune checkpoint inhibitors, chemotherapy remains the standard therapy for patients with pancreatic ductal adenocarcinoma (PDAC). As the combinations of chemotherapy, including the FOLFIRINOX [5-fluorouracil, F; irinotecan, I; and oxaliplatin, O (FIO)] regimen, and immune checkpoint inhibitors have failed to demonstrate clinical benefit in patients with metastatic PDAC tumors, there is increasing interest in identifying therapeutic approaches to potentiate ICI efficacy in patients with PDAC. In this study, we report that neoadjuvant FOLFIRINOX-treated human PDAC tumors exhibit increased MEK/ERK activation. We also show elevated MEK/ERK signaling in ex vivo PDAC slice cultures and cell lines treated with a combination of FIO. In addition, we find that the KPC-FIO cells, established from repeated treatment of mouse PDAC cell lines with six to eight cycles of FIO, display enhanced ERK phosphorylation and demonstrate increased sensitivity to MEK inhibition in vitro and in vivo. Significantly, the KPC-FIO cells develop tumors with a proinflammatory immune profile similar to human PDAC tumors after neoadjuvant FOLFIRINOX treatment. Furthermore, we found that the MEK inhibitor trametinib enables additional infiltration of highly functional CD8+ T cells into the KPC-FIO tumors and potentiates the efficacy of anti-PD-1 antibody in syngeneic mouse models. Our findings provide a rationale for combining trametinib and anti-PD-1 antibodies in patients with PDAC after neoadjuvant or short-term FOLFIRINOX treatment to achieve effective antitumor responses.
Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo
Authors: Schiemann Kai , Belousova Natalya , Matevossian Armine , Nallaparaju Kalyan C. , Kradjian Giorgio , Pandya Meghana , Chen Zhouxiang , Aral Esengul , Krauel Eva-Maria , Petrova Elissaveta , Boesler Carsten , Kitzing Thomas , Lecomte Marc , Wagner Christian , Blayo Anne Laure , Schann Stephan , Huck Bayard , Moisan Jacques , Zaynagetdinov Rinat
Published: August 2024

While A2A adenosine receptor (AR) was considered as a major contributor to adenosine-mediated immunosuppression, A2B, having the lowest affinity to adenosine, has also emerged as a potential contributor to tumor promotion. Therefore, in adenosine-rich tumor microenvironment (TME), where A2B could be complementary and/or compensatory to A2A, simultaneous targeting of A2A and A2B ARs can provide higher potential for cancer immunotherapy. We developed M1069—a highly selective dual antagonist of the A2A and A2B AR. In assays with primary human and murine immune cells, M1069 rescued IL2 production from T cells (A2A dependent) and inhibited VEGF production by myeloid cells (A2B dependent) in adenosine-high settings. M1069 also demonstrated superior suppression of the secretion of protumorigenic cytokines CXCL1, CXCL5, and rescue of IL12 secretion from adenosine-differentiated dendritic cells compared to an A2A-selective antagonist (A2Ai). In a one-way mixed lymphocyte reaction (MLR) assay, adenosine-differentiated human and murine dendritic cells treated with M1069 demonstrated superior T-cell stimulatory activity compared to dendritic cells differentiated in presence of A2Ai. In vivo, M1069 decreased tumor growth as a monotherapy and enhanced antitumor activity of bintrafusp alfa (BA) or cisplatin in syngeneic adenosinehi/CD73hi 4T1 breast tumor model, but not in the CD73 knockout 4T1 tumor model or in adenosinelow/CD73low MC38 murine colon carcinoma model. In summary, our dual A2A/A2B AR antagonist M1069 may counteract immune-suppressive mechanisms of high concentrations of adenosine in vitro and in vivo and enhance the antitumor activity of other agents, including BA and cisplatin.
Table 3 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

ClinicalTrials.Gov reporting and missing data among unpublished endpoints
Table S8 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S8 shows Prevalence of adverse events
Table 1 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Characteristics of selected phase III randomized controlled trials in oncology
Table S4 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S4 shows Adverse Events Included in the Co-primary Endpoint: Worst Grade by Patient
Table S17 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S17 shows Comparison of F2-Isoprostanes Control and Intervention Changes 60 minutes after Cycle 6
Table S1 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S1 shows Participating Sites and the Number of Patients Enrolled in the Trial at Each Institution
Table 3 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

AEs for coprimary endpoints
Table 1 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Demographic and baseline characteristics
Supplementary Methods from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Supplementary methods include study design and participants, outcomes and statistical analysis, FACT-P questionnaire, pharmacokinetics, and F2-Isoprostanes
Figure S2 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Figure S2 shows Plasma ascorbic acid concentrations
Figure 2 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Key secondary endpoints. Key secondary endpoints include rPFS, OS, duration of PSA response, and quality of life measured using the FACT-P instrument. A, rPFS and (B) OS are presented for docetaxel + HDIVC vs. docetaxel + placebo. The KM method was used to estimate the median, 12-month, and 24-month rates of rPFS and OS. C, Duration of PSA response and (D) FACT-P scores are presented for docetaxel + HDIVC vs. docetaxel + placebo.
Figure 1 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

CONSORT diagram. The diagram shows eligibility assessment, randomization, allocation, discontinuations, and numbers of subjects analyzed.
O avanço da Justiça sobre os agricultores de maconha em Belém de São Francisco na década de 1980
Authors: Rosa Lilian , Fraga Paulo Cesar Pontes
Published: August 2024

O trabalho analisa sete processos-crime da década de 1980 instaurados pela Justiça Pública da comarca de Belém de São Francisco contra agricultores de maconha, provavelmente os primeiros processos desse tipo. Baseada em teorias de Fluxo de Processos, a análise sugere que a morosidade no cumprimento dos atos processuais inviabilizou a condenação dos réus. Os processos parecem revelar que o objetivo das ações judiciais não se concentrava no desmantelamento de grupos ou agentes criminosos que atuavam no sentido de estruturar a atividade ilícita, nem em punir mais veementemente os indivíduos incriminados. Por fim, o artigo explora as contradições inerentes às prioridades das políticas de drogas estabelecida pelo ditadura civil-militar, por meio da lei 6368/76, com a ação do judiciário da referida comarca. O tipo de ação desempenhava mais uma função política de propaganda de combate a esses cultivos do que propriamente uma ação de extermínio das referidas atividades.
Em defesa das crianças? A instrumentalização da democracia no discurso antigênero
Authors: Camargo Bruna Quinsan
Published: August 2024

This article seeks to analyze, through the Content Analysis of parliamentary speeches and videos of leaderships and religious public figures, the discourse on the so-called "gender ideology" in the Brazilian House of Representatives between 2015 and 2019. In order to prevent the advancement of sexual and reproductive rights and spread traditional morality in education, the lexicon of democracy is used as a tool and Christian values receive a secular camouflage. Therefore, the de-democratizing political-religious action is legitimized in the public arena, enabling, as a consequence, the precariousness of lives and the perpetuation of inequalities and violence faced by historically subalternized groups, such as trans people, cisgender women and sexual dissidents.
De “merdalheres” a “conservadias”: o discurso de ódio masculinista
Authors: Silva Bruna Camilo de Souza Lima e , Chacham Alessandra Sampaio
Published: August 2024

Este artigo apresenta os resultados de uma pesquisa que investigou a interação entre os discursos masculinistas nas redes sociais e a extrema-direita no cenário político brasileiro. A análise se concentra na relação entre os discursos masculinistas veiculados nas redes sociais, a misoginia e seu vínculo com a extrema-direita. Os conceitos centrais de misoginia e masculinidade são primeiramente delineados para estabelecer uma base teórica sólida e desenvolver nossa análise. A metodologia adotada compreende uma pesquisa exploratória que abarca blogs, grupos no aplicativo Telegram e materiais fornecidos pela professora e pesquisadora Lola Aronovich. Os resultados da pesquisa esboçam a convergência entre os discursos masculinistas e a extrema-direita. Ao examinar os conteúdos desses grupos e blogs, observa-se uma associação entre os grupos masculinistas e a misoginia, a qual, por sua vez, está interligada com elementos dos discursos da extrema-direita. A interseção desses discursos sugere que as ideias masculinistas proporcionam um terreno fértil para a disseminação de ideais extremistas.
Análise dos processos de generificação a partir de estudos brasileiros: uma revisão de escopo
Authors: Correia Ruth Almeida , Barros Valexa Moraes de , Toledo Dafne Serafim Cosendey , Leitão Consuelena Lopes , Torres Marck de Souza
Published: August 2024

O objetivo do artigo é explorar e sistematizar o conceito de generificação por meio do mapeamento da literatura acadêmico-científica brasileira, por meio da revisão de escopo, nas bases de dados: BVS, Scopus, SciELO, LILACS e Periódicos CAPES no período de 2019 a 2023. Como resultado, foram identificados 196 artigos e 24 foram selecionado para integra a revisão. Os eixos centrais identificados se dividiram em: construção social, generificação e interseccionalidade, atravessamentos da generificação na formação profissionalizante, reafirmação de práticas generificadas e críticas à binariedade hegemônica. A maioria dos artigos foram produzidos e publicados do Sul e Sudeste brasileiro com apenas uma publicação da região Norte. Apesar de não ser conceituado, o termo generificação é problematizado, lançando críticas à binariedade hegemônica e sua construção nos diversos espaços de formação. A literatura científica evidencia a existência dos processos de generificação dentro das produções acadêmicas e no cotidiano, a análise detalhada dos artigos revela escassez de estudos aprofundados que examinem suas nuances e aplicações específicas no contexto cultural brasileiro.
Qual o lugar da mulher negra nos estudos da academia? Uma investigação da produção stricto sensu sobre a mulher negra no Brasil
Authors: Andrade Tales Gandi Veloso de , Pessoa Virgínia Marinely Almeida e , Miranda Viviane Santos , Oliveira Romilda Sergia
Published: August 2024

Observing the intersectional relationship that permeates the experience of black women, their daily confrontation with challenges that combine markers of race, class and gender, this article seeks to analyze the academic perspective on such women, essentially from stricto sensu postgraduate studies. . We sought to identify, through a qualitative-quantitative study, how the theme is approached in Brazilian higher education institutions and the characteristics associated with their production: where they are being produced (universities, postgraduate programs, states and capitals), what is the profile of the authors, as well as the contrast of their productivity with other ethnic-racial themes. The research included a sample of 2,723 theses and dissertations and covered a five-year period, from 2017 to 2021. Based on the data and analyzes developed, it was possible to identify that the majority of stricto sensu productions come from public universities, which The majority of authors are women, with the humanities leading among areas of knowledge and, despite other ethnic-racial themes being on the rise in recent years, productions on black women have been decreasing. Some of the causalities pointed out are the cuts in scholarships within the scope of higher education, which corroborate the intensification of the social fragility to which these women are already subjected.
Problemas de Saúde dos Alunos da FEA-RP/USP – Um Exame do Período 2015-2019
Authors: Diniz Eliezer Martins
Published: August 2024

This article systematizes primary data on health problems of FEA-RP/USP students in the period 2015-2019 from a database of the unit's Undergraduate Service. This systematization makes it possible to know the nature of the unit's health problems and design more effective educational management policies to deal with health problems. It can be concluded that: there is an increase in requests related to health problems; the composition of requests is in accordance with the composition by sex of the student body; student requests do not occur uniformly per course; mental health problems increase in importance towards the end of the period; requests for home problem sets are of increasing importance; total leave of absence requests have a decreasing importance in percentage terms; The reasons for total leave of absence vary in importance.
Differentiating Left Ventricular Remodeling in Aortic Stenosis From Systemic Hypertension
Authors: Mahmod Masliza , Chan Kenneth , Fernandes Joao F. , Ariga Rina , Raman Betty , Zacur Ernesto , Law Ho-fon Royce , Rigolli Marzia , Francis Jane M. , Dass Sairia , O’Gallagher Kevin , Myerson Saul G. , Karamitsos Theodoros D. , Neubauer Stefan , Lamata Pablo
Published: August 2024

BACKGROUND:

Left ventricular (LV) hypertrophy occurs in both aortic stenosis (AS) and systemic hypertension (HTN) in response to wall stress. However, differentiation of hypertrophy due to these 2 etiologies is lacking. The aim was to study the 3-dimensional geometric remodeling pattern in severe AS pre- and postsurgical aortic valve replacement and to compare with HTN and healthy controls.

METHODS:

Ninety-one subjects (36 severe AS, 19 HTN, and 36 healthy controls) underwent cine cardiac magnetic resonance. Cardiac magnetic resonance was repeated 8 months post-aortic valve replacement (n=18). Principal component analysis was performed on the 3-dimensional meshes reconstructed from 109 cardiac magnetic resonance scans of 91 subjects at end-diastole. Principal component analysis modes were compared across experimental groups together with conventional metrics of shape, strain, and scar.

RESULTS:

A unique AS signature was identified by wall thickness linked to a LV left-right axis shift and a decrease in short-axis eccentricity. HTN was uniquely linked to increased septal thickness. Combining these 3 features had good discriminative ability between AS and HTN (area under the curve, 0.792). The LV left-right axis shift was not reversible post-aortic valve replacement, did not associate with strain, age, or sex, and was predictive of postoperative LV mass regression (R
2
=0.339,
P
=0.014).

CONCLUSIONS:

Unique remodeling signatures might differentiate the etiology of LV hypertrophy. Preliminary findings suggest that LV axis shift is characteristic in AS, is not reversible post-aortic valve replacement, predicts mass regression, and may be interpreted to be an adaptive mechanism.
Predictive and Diagnostic Value of the Angiogenic Proteins in Patients With Chronic Kidney Disease
Authors: Melamed Nir , Kingdom John C. , Fu Lei , Yip Paul M. , Arruda-Caycho Isabel , Hui Dini , Hladunewich Michelle A.
Published: August 2024

BACKGROUND:

Our objective was to investigate the predictive and diagnostic accuracy of the angiogenic proteins sFlt-1 (soluble fms–like tyrosine kinase-1) and PlGF (placental growth factor) for preterm preeclampsia and explore the relationship between renal function and these proteins.

METHODS:

We completed a blinded, prospective, longitudinal, observational study of patients with chronic kidney disease followed at a tertiary center (2018–2023). Serum samples were obtained at 3 time points along gestation (planned sampling): 12–16, 18–22, and 28–32 weeks. In addition, samples were obtained whenever preeclampsia was suspected (indicated sampling). sFlt-1 and PlGF levels remained concealed until the study ended. The primary outcome was preterm preeclampsia. The planned and indicated samples were used to estimate the predictive and diagnostic accuracy of the angiogenic proteins, respectively.

RESULTS:

Of the 97 participants, 21 (21.6%) experienced preterm preeclampsia. In asymptomatic patients with chronic kidney disease, the angiogenic proteins were predictive of preterm preeclampsia only when sampled in the third trimester, in which case the sFlt-1/PlGF ratio (false positive rate of 37% for a detection rate of 80%) was more predictive than either sFlt-1 or PlGF in isolation. In patients with suspected preeclampsia, the diagnostic accuracy of the sFlt-1/PlGF ratio (false positive rate of 26% for a detection rate of 80%) was higher than that of sFlt-1 and PlGF in isolation. Diminished renal function was associated with increased levels of PlGF.

CONCLUSIONS:

sFlt-1 and PlGF can effectively predict and improve the diagnostic accuracy for preterm preeclampsia among patients with chronic kidney disease. The optimal sFlt-1/PlGF ratio cutoff to rule out preeclampsia may need to be lower in patients with impaired renal function.
A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers
Authors: Schofield Holly , Hill Ryan M. , Feys Odile , Holmes Niall , Osborne James , Doyle Cody , Bobela David , Corvilain Pierre , Wens Vincent , Rier Lukas , Bowtell Richard , Ferez Maxime , Mullinger Karen J. , Coleman Sebastian , Rhodes Natalie , Rea Molly , Tanner Zoe , Boto Elena , de Tiège Xavier , Shah Vishal , Brookes Matthew J.
Published: August 2024

Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; however, the field has been revolutionised in recent years by the introduction of optically-pumped magnetometers (OPMs). OPMs enable measurement of the MEG signal without cryogenics, and consequently the conception of “OPM-MEG” systems which ostensibly allow increased sensitivity and resolution, lifespan compliance, free subject movement, and lower cost. However, OPM-MEG is in its infancy with existing limitations on both sensor and system design. Here, we report a new OPM-MEG design with miniaturised and integrated electronic control, a high level of portability, and improved sensor dynamic range. We show that this system produces equivalent measures compared with an established OPM-MEG instrument; specifically, when measuring task-induced beta-band, gamma-band, and evoked neuro-electrical responses, source localisations from the two systems were comparable and temporal correlation of measured brain responses was >0.7 at the individual level and >0.9 for groups. Using an electromagnetic phantom, we demonstrate improved dynamic range by running the system in background fields up to 8 nT. We show that the system is effective in gathering data during free movement (including a sitting-to-standing paradigm) and that it is compatible with simultaneous electroencephalography (EEG). Finally, we demonstrate portability by moving the system between two laboratories. Overall, our new system is shown to be a significant step forward for OPM-MEG and offers an attractive platform for next generation functional medical imaging.
Lumbosacral spinal cord functional connectivity at rest: From feasibility to reliability
Authors: Ricchi Ilaria , Kinany Nawal , Van De Ville Dimitri
Published: August 2024

In the past decade, exploration of spontaneous blood-oxygen-level-dependent (BOLD) signal fluctuations has expanded beyond the brain to include the spinal cord. While most studies have predominantly focused on the cervical region, the lumbosacral segments play a crucial role in motor control and sensory processing of the lower limbs. Addressing this gap, the aims of the current study were twofold: first, confirming the presence and nature of organized spontaneous BOLD signals in the human lumbosacral spinal cord; second, systematically assessing the impact of various denoising strategies on signal quality and functional connectivity (FC) patterns. Given the susceptibility of spinal cord functional magnetic resonance imaging (fMRI) to noise, this step is pivotal to ensure the robustness of intrinsic FC. Our findings uncovered bilateral FC between the ventral and dorsal horns. Importantly, these patterns were consistently observed across denoising methods and demonstrating fair to excellent split-half temporal stability. Importantly, the evaluation of diverse denoising strategies highlighted the efficacy of physiological noise modeling (PNM)-based pipelines in cleaning the signal while preserving the strength of connectivity estimates. Together, our results provide evidence of robust FC patterns in the lumbosacral spinal cord, thereby paving the way for future studies probing caudal spinal activity.
Mind Melds: Verbal Labels Induce Greater Representational Alignment
Authors: Suffill Ellise , van Paridon Jeroen , Lupyan Gary
Published: August 2024

What determines whether two people represent something in a similar way? We examined the role of verbal labels in promoting representational alignment. Across two experiments, three groups of participants sorted novel shapes from two visually dissimilar categories. Prior to sorting, participants in two of the groups were pre-exposed to the shapes using a simple visual matching task designed to reinforce the visual category structure. In one of these groups, participants additionally heard one of two nonsense category labels accompanying the shapes. Exposure to these redundant labels led people to represent the shapes in a more categorical way, which led to greater alignment between sorters. We found this effect of label-induced alignment despite the two categories being highly visually distinct and despite participants in both pre-exposure conditions receiving identical visual experience with the shapes. Experiment 2 replicated this basic result using more even more stringent testing conditions. The results hint at the possibly extensive role that labels may play in aligning people’s mental representations.
Post-rut aggression in caribou: limited evidence for interference competition but strong evidence for male harassment
Authors: Webber Quinn M.R. , Vander Wal Eric
Published: August 2024

Social competition for resources is widespread among animals. Females of many species compete for foraging resources through interference competition, which is a behavioural interaction between animals that reduces an individual’s access to shared resources. In addition to competition from other females, females also often face harassment from males during and after the breeding season. The female competition hypothesis predicts that female-initiated aggression associated with foraging competition increases as a function of group size, but we expected this effect to be more pronounced in higher quality foraging habitat. The male harassment hypothesis predicts that male harassment of females should also increase as a function of group size as well as a function of the ratio of males to other group members. Here, we tested the female competition and male harassment hypotheses for caribou (Rangifer tarandus) within the context of variation in the social environment (i.e., group size and sex ratio) and the physical environment (i.e., variation in habitat quality). We conducted focal observations of caribou on Fogo Island, Newfoundland, over three years and quantified aggressive social interactions in different habitat types to test our hypotheses. Specifically, we took advantage of natural variation in caribou behaviour in our system and observed caribou foraging in an enhanced habitat (i.e., recreational sports complex field) and natural habitat (i.e., lichen barrens). We found limited support for the female competition hypothesis, possibly because of females’ propensity to increase foraging rates in enhanced habitats. By contrast, we found strong support for the male harassment hypothesis, where males increase the frequency of harassment as group size increased. Our results suggest costs of grouping for female caribou in the post-rut time period may be related to the presence of males potentially seeking mating opportunities.
Designing of nematode egg parasitic fungus, Purpureocillium lilacinum, nanoemulsion for management of Meloidogyne incognita infection in tomato
Authors: Nagachandrabose Seenivasan , Sivathanu Logaraj , Pon Sathya Moorthy , Kalimuthu Raja , Somasundaram Prabhu , Subramanian K.S.
Published: August 2024

Purpureocillium lilacinum is a potent biocontrol agent against Meloidogyne spp. and various other plant-parasitic nematodes in crops. However, existing commercial formulations of P. lilacinum suffer from drawbacks like short shelf life and inconsistent performance in different environmental conditions. To address these issues, a new nano-formulation of P. lilacinum was developed and tested against Meloidogyne incognita infecting tomatoes. Initially, edible oil-based emulsions were prepared using probe ultrasonication, with 40 formulations screened and 14 selected for further testing. Seven of these emulsions remained stable at room temperature (28 ± 4°C) for 8 weeks, with stability assessed based on particle size, zeta potential, and particle shape using particle size analysis and transmission electron microscopy (TEM). Among these, NE 8 (comprising 10 ml of 1% carboxyl methyl cellulose (CMC), 1.25 ml of Tween 80 and 5 ml of sunflower oil) exhibited superior characteristics, with an average particle size of 226.6 nm, a zeta potential of −54.80 mV, and a spherical morphology under TEM examination. The P. lilacinum nanoemulsion formulation was produced by homogenising NE 8 emulsion and spores at a 1:1 ratio, ensuring efficient spore dispersion and encapsulation without loss of viability. In vitro tests demonstrated 100% immobility of M. incognita second-stage juveniles (J2) and 100% parasitism of eggs at a concentration of 5.0 ml l−1. Under glasshouse conditions, soil drenching with the nano-formulation at concentrations ranging from 0.5 to 5.0 ml l−1 resulted in enhanced tomato growth and significant suppression of M. incognita populations in soil and roots, with increased egg mass parasitism. Bio-safety tests confirmed that P. lilacinum nano-formulation at concentrations of 0.25 ml l−1 and 5.0 ml l−1 had no harmful effects on the earthworm Eudrilus eugeniae.
A new restricted-range Melanorivulus (Cyprinodontiformes: Rivulidae) from the upper rio Guaporé, Chapada dos Parecis, Brazil
Authors: NIELSEN DALTON TAVARES BRESSANE , OHARA WILLIAN MASSAHARU
Published: August 2024

A new species of Melanorivulus, belonging to the Melanorivulus zygonectes species group, is described from the rio Galera, a tributary of the right bank of the upper rio Guaporé, Amazon basin, Mato Grosso state, Brazil. It is diagnosed from congeners by the following combination of characters: absence of pelvic fins; presence of a black band along the entire caudal-fin margin in males, typically more conspicuous on dorsal and ventral portions; presence of a wide oblique bars anteriorly and wide chevron-like marks posteriorly to middle of flank. This is the first record of the genus Melanorivulus for the rio Madeira basin.
NEW NON-MARINE OSTRACOD GENERA AND SPECIES OF APTIAN AGE FROM ARARIPE BASIN, NORTHEAST BRAZIL
Authors: ALMEIDA-LIMA DÉBORA SOARES DE , GUZMÁN JULIANA , MAIA RENATA JULIANA ARRUDA , SOUSA ARIANY DE JESUS E , PIOVESAN ENELISE KATIA
Published: August 2024

The Ostracoda Subclass comprises the most expressive group of calcareous microfossils in the deposits of the Araripe Basin, especially in its post-rift sequence, which is represented by the Santana Group, of Late Aptian age (= Alagoas Local Stage). Due to the abundance, ostracod species are of great importance for understanding the evolution of the Araripe Basin, with direct application in biostratigraphic and paleoecological analyses. Improving these important applications involves refining the taxonomy of these ostracods, which also contributes to understanding the diversity of this fauna. Increasing knowledge about the ostracod group, this paper describes new and rare taxa recovered from outcrop and well core samples from the Araripe Basin. Two new genera are proposed, Batecypris gen. nov. and Macunhaella gen. nov., and five new species Batecypris reticularis sp. nov., Macunhaella posteroaltis sp. nov., Timiriasevia aratra sp. nov., Theriosynoecum favus sp. nov. and Wolburgiopsis magnafossa sp. nov.. These five taxa were assigned to the families Cyprididae Baird, 1845 and Limnocytheridae Klie, 1938, which comprise other important and known genera for the Araripe Basin. This study shows that in the Araripe Basin the mentioned families can be more diverse than already known, adding value to the understanding of the pre-salt section deposition.
Factors Affecting Health Care Utilization Associations Among Young Adolescents With Persistent or Recurrent Pain
Authors: Ahn Rachel Elise , Senger-Carpenter Thea , Voepel-Lewis Terri
Published: August 2024

Background:

It is unclear how family factors affect health care utilization among youth with persistent or recurrent pain, despite potential relevance to interventions targeting treatment barriers.

Objective:

We aimed to examine health care utilization among young adolescents with persistent or recurrent pain and family factor influences toward higher health care utilization.

Methods:

We analyzed longitudinal data from the Adolescent Brain Cognitive Development Study and coded pain as none, infrequent (present 1-2 years), or persistent/recurrent pain (present 3-4 years). Higher health care utilization was coded as nonroutine or emergency department visit at ≥2 years. Parent-reported education, pain status, family income, and insurance status were recorded. Logistic regression examined the contributions of the child’s pain and family factors toward higher health care utilization.

Results:

Among 5960 youth, 1908 (32%) had persistent/recurrent pain and 2199 (37%) had infrequent pain. Youth with persistent/recurrent pain were more likely to have higher health care utilization compared to those without pain (adjusted odds ratio [OR]: 2.39) or those with infrequent pain (OR: 1.79). Higher health care utilization was associated with parents’ pain (adjusted OR: 1.22) and higher education (adjusted OR: 1.44), and family income below the poverty line (adjusted OR: 1.26), controlling for child characteristics and pain status.

Conclusion:

Findings show how youths’ persistent/recurrent pain, parental, and family socioeconomic factors affect health care utilization among young adolescents, emphasizing a need for family-centered care and economic policies.
NXPH4 mediated by m5C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation
Authors: Yang Lei , Shi Jiawen , Zhong Mingyang , Sun Pingping , Zhang Xiaojing , Lian Zhengyi , Yin Hang , Xu Lijun , He Guyin , Xu Haiyan , Wu Han , Wang Ziheng , Miao Kai , Huang Jianfei
Published: August 2024

Objective

Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and therapeutic approaches for CRC, there is a need to investigate more accurate and efficient biomarkers.

Methods

Core regulatory genes were screened using the TCGA database, and the expression of neurexophilin 4 (NXPH4) and its prognostic implications were validated using tissue microarray staining. The assessment of NXPH4 functions involved a range of experiments, including cellular, organoid, and murine models. Furthermore, a regulatory network between m5C, NXPH4, and HIF1A was established through several in vitro experiments.

Results

The overexpression of NXPH4 is associated with unfavorable prognoses in patients with CRC and hepatocellular carcinoma. Additionally, it facilitates the progression of malignant tumors both in laboratory settings and in living organisms of colorectal carcinoma. Our research also reveals that NXPH4 mRNA can avoid degradation through RNautophagy, relying on an m5C-dependent mechanism. Moreover, NXPH4 amplifies the HIF signaling pathway and stabilizes HIF1A by competitively binding to PHD4.

Conclusions

NXPH4, regulated by m5C, promotes malignant tumor progression and regulates the HIF pathway. Consequently, targeting NXPH4 through molecular therapies could potentially serve as an efficacious therapeutic strategy for the management of CRC exhibiting elevated NXPH4 expression.

Graphical abstract
Modeling relaxation experiments with a mechanistic model of gene expression
Authors: Estavoyer Maxime , Dufeu Marion , Ranson Grégoire , Lefort Sylvain , Voeltzel Thibault , Maguer-Satta Véronique , Gandrillon Olivier , Lepoutre Thomas
Published: August 2024

Background

In the present work, we aimed at modeling a relaxation experiment which consists in selecting a subfraction of a cell population and observing the speed at which the entire initial distribution for a given marker is reconstituted.

Methods

For this we first proposed a modification of a previously published mechanistic two-state model of gene expression to which we added a state-dependent proliferation term. This results in a system of two partial differential equations. Under the assumption of a linear dependence of the proliferation rate with respect to the marker level, we could derive the asymptotic profile of the solutions of this model.

Results

In order to confront our model with experimental data, we generated a relaxation experiment of the CD34 antigen on the surface of TF1-BA cells, starting either from the highest or the lowest CD34 expression levels. We observed in both cases that after approximately 25 days the distribution of CD34 returns to its initial stationary state. Numerical simulations, based on parameter values estimated from the dataset, have shown that the model solutions closely align with the experimental data from the relaxation experiments.

Conclusion

Altogether our results strongly support the notion that cells should be seen and modeled as probabilistic dynamical systems.
Impact of the medical fitness model on long term health outcomes in older adults
Authors: Brar Ranveer , Katz Alan , Ferguson Thomas , Whitlock Reid , Di Nella Michelle , Bohm Clara , Rigatto Claudio , Komenda Paul , Boreskie Sue , Solmundson Carrie , Kosowan Leanne , Tangri Navdeep
Published: August 2024

Background

Physical inactivity is common among older adults and is associated with poor health outcomes. Medical fitness facilities provide a medically focused approach to physical fitness and can improve physical activity in their communities. This study aimed to assess the relationship between membership in the medical fitness model and all-cause mortality, health care utilization, and major adverse cardiac events in older adults.

Methods

A propensity weighted retrospective cohort study linked individuals that attended medical fitness facilities to provincial health administrative databases. Older adults who had at least 1 year of health coverage from their index date between January 1st, 2005 to December 31st 2015 were included. Controls were assigned a pseudo-index date at random based on the frequency distribution of index dates in members. Members were stratified into low frequency attenders (< 1 Weekly Visits) and regular frequency attenders (> 1 Weekly Visits). Time to event models estimated the hazard ratios (HRs) for risk of all-cause mortality and major adverse cardiac event. Negative binomial models estimated the risk ratios (RRs) for risk of hospitalizations, outpatient primary care visits and emergency department visits.

Results

Among 3,029 older adult members and 91,734 controls, members had a 45% lower risk of all-cause mortality (HR: 0.55, 95% CI: 0.50 – 0.61), 20% lower risk of hospitalizations (RR: 0.80, 95% CI: 0.75 – 0.84), and a 27% (HR: 0.72, 95% CI: 0.66 – 0.77), lower risk of a major adverse cardiovascular event. A dose–response effect with larger risk reductions was associated with more frequent attendance as regular frequency attenders were 4% more likely to visit a general practitioner for a routine healthcare visit (RR: 1.04, 95% CI: 1.01 – 1.07), but 23% less likely to visit the emergency department (RR: 0.87, 95% CI: 0.82 – 0.92).

Conclusions

Membership at a medical fitness facility was associated with a decreased risk of mortality, health care utilization and cardiovascular events. The medical fitness model may be an alternative approach for public health strategies to promote positive health behaviors in older adult populations.
Exploring factors affecting the acceptance of fall detection technology among older adults and their families: a content analysis
Authors: Huang Hsin-Hsiung , Chang Ming-Hao , Chen Peng-Ting , Lin Chih-Lung , Sung Pi-Shan , Chen Chien-Hsu , Fan Sheng-Yu
Published: August 2024

Background

This study conducted in-depth interviews to explore the factors that influence the adoption of fall detection technology among older adults and their families, providing a valuable evaluation framework for healthcare providers in the field of fall detection, with the ultimate goal of assisting older adults immediately and effectively when falls occur.

Methods

The method employed a qualitative approach, utilizing semi-structured interviews with 30 older adults and 29 families, focusing on their perspectives and expectations of fall detection technology. Purposive sampling ensured representation from older adults with conditions such as Parkinson's, dementia, and stroke.

Results

The results reveal key considerations influencing the adoption of fall-detection devices, including health factors, reliance on human care, personal comfort, awareness of market alternatives, attitude towards technology, financial concerns, and expectations for fall detection technology.

Conclusions

This study identifies seven key factors influencing the adoption of fall detection technology among older adults and their families. The conclusion highlights the need to address these factors to encourage adoption, advocating for user-centered, safe, and affordable technology. This research provides valuable insights for the development of fall detection technology, aiming to enhance the safety of older adults and reduce the caregiving burden.
Examining the mental health services among people with mental disorders: a literature review
Authors: Gao Yunqi , Burns Richard , Leach Liana , Chilver Miranda R. , Butterworth Peter
Published: August 2024

Background

Mental disorders are a significant contributor to disease burden. However, there is a large treatment gap for common mental disorders worldwide. This systematic review summarizes the factors associated with mental health service use.

Methods

PubMed, Scopus, and the Web of Science were searched for articles describing the predictors of and barriers to mental health service use among people with mental disorders from January 2012 to August 2023. The initial search yielded 3230 articles, 2366 remained after removing duplicates, and 237 studies remained after the title and abstract screening. In total, 40 studies met the inclusion and exclusion criteria.

Results

Middle-aged participants, females, Caucasian ethnicity, and higher household income were more likely to access mental health services. The use of services was also associated with the severity of mental symptoms. The association between employment, marital status, and mental health services was inconclusive due to limited studies. High financial costs, lack of transportation, and scarcity of mental health services were structural factors found to be associated with lower rates of mental health service use. Attitudinal barriers, mental health stigma, and cultural beliefs also contributed to the lower rates of mental health service use.

Conclusion

This systematic review found that several socio-demographic characteristics were strongly associated with using mental health services. Policymakers and those providing mental health services can use this information to better understand and respond to inequalities in mental health service use and improve access to mental health treatment.