bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of NonSurgical Periodontal Therapy on Plasma Levels of IL-17 in Chronic Periodontitis Patients with Well Controlled Type-II Diabetes Mellitus—A Clinical Study
Authors: Jayakumar Sunandhakumari Vishnu , Sadasivan Arun , Koshi Elizabeth , Krishna Aswathy , Alim Aneesh , Sebastian Aneesh
Published: June 2018

For years the pathogenesis of periodontitis was under an immunological Th1/Th2 paradigm. Th1 cells are considered to afford protection against the intracellular pathogens. These cells produce the interferons (IFN) that are involved in macrophage activation, which, in turn, plays an important role in phagocytosis, complement fixation, and opsonization. Th2 cells are thought to have evolved as a form of protection against parasitic helminthes. Th17 subset of CD4Not Necessary+ T cells was identified in the year 2005, which added greater complexity to Th function and are pro inflammatory in nature. Interleukins (ILs) have the ability to alter immunological changes and they also possess the ability to regulate lymphocyte differentiation and haemopoietic stem cells, cell proliferation, and motility, which are classified as pro-inflammatory and anti-inflammatory. There are numerous studies that reported IL-17 levels associated with chronic periodontitis (CP) development. Type II diabetes mellitus (DM) is considered a risk factor for the development of periodontal diseases because the incidence, progression, and severity of periodontal diseases are more common with Type II DM than without DM. This study was aimed at evaluating whether non-surgical periodontal therapy had any effect on plasma concentrations of Interleukin-17 in systemically healthy chronic periodontitis patients and in chronic periodontitis patients with well controlled Type II Diabetes mellitus. Patients were divided into the two groups including the chronic periodontitis group (20 subjects) and the chronic periodontitis with well-controlled Type II Diabetes mellitus group (20 subjects). The Gingival Index and Plaque Index as well as the clinical Attachment Level (CAL) were taken from all the patients of two groups after evaluating fasting blood sugar, post prandial blood sugar, and the Glycated Hemoglobin Level (HbA1c). Then 5 mL blood samples were collected from each patient and plasma was separated and the IL-17 level is evaluated using the ELISA method. Then, as part of phase I periodontal therapy, scaling and root planning was performed. Patients were recalled after one month and clinical and biochemical parameters were reevaluated. Non-surgical periodontal therapy resulted in a reduction of plasma levels of IL-17 in chronic periodontitis patients with and without well controlled Type II Diabetes mellitus.
Vacuum Landscaping: Cause of Nonlocal Influences without Signaling
Authors: Grössing Gerhard , Fussy Siegfried , Mesa Pascasio Johannes , Schwabl Herbert
Published: June 2018

In the quest for an understanding of nonlocality with respect to an appropriate ontology, we propose a “cosmological solution”. We assume that from the beginning of the universe each point in space has been the location of a scalar field representing a zero-point vacuum energy that nonlocally vibrates at a vast range of different frequencies across the whole universe. A quantum, then, is a nonequilibrium steady state in the form of a “bouncer” coupled resonantly to one of those (particle type dependent) frequencies, in remote analogy to the bouncing oil drops on an oscillating oil bath as in Couder’s experiments. A major difference to the latter analogy is given by the nonlocal nature of the vacuum oscillations. We show with the examples of double- and n-slit interference that the assumed nonlocality of the distribution functions alone suffices to derive the de Broglie–Bohm guiding equation for N particles with otherwise purely classical means. In our model, no influences from configuration space are required, as everything can be described in 3-space. Importantly, the setting up of an experimental arrangement limits and shapes the forward and osmotic contributions and is described as vacuum landscaping.
Thermodynamic Black Holes
Authors: Ruppeiner George
Published: June 2018

Black holes pose great difficulties for theory since gravity and quantum theory must be combined in some as yet unknown way. An additional difficulty is that detailed black hole observational data to guide theorists is lacking. In this paper, I sidestep the difficulties of combining gravity and quantum theory by employing black hole thermodynamics augmented by ideas from the information geometry of thermodynamics. I propose a purely thermodynamic agenda for choosing correct candidate black hole thermodynamic scaled equations of state, parameterized by two exponents. These two adjustable exponents may be set to accommodate additional black hole information, either from astrophysical observations or from some microscopic theory, such as string theory. My approach assumes implicitly that the as yet unknown microscopic black hole constituents have strong effective interactions between them, of a type found in critical phenomena. In this picture, the details of the microscopic interaction forces are not important, and the essential macroscopic picture emerges from general assumptions about the number of independent thermodynamic variables, types of critical points, boundary conditions, and analyticity. I use the simple Kerr and Reissner-Nordström black holes for guidance, and find candidate equations of state that embody several the features of these purely gravitational models. My approach may offer a productive new way to select black hole thermodynamic equations of state representing both gravitational and quantum properties.
Productive Disruptions: Rethinking the Role of Off-Task Interactions in Collaborative Mathematics Learning
Authors: Langer-Osuna Jennifer M.
Published: June 2018

This paper confronts the myth that all off-task interactions in mathematics classrooms is detrimental to learning. To do so, this paper first explores links between participation, learning, and identity in mathematics education research that points to the importance of positional resources. Positional resources are related to identity processes and carry central functions that regulate learning and doing mathematics together. The paper then frames off-task behavior as an important positional resource in collaborative mathematics learning environments. With these ideas in mind, the paper then closes with new questions for research.
Preparation of Hierarchical Porous Carbon from Waterweed and Its Application in Lithium/Sulfur Batteries
Authors: Liang Chunyong , Zhang Xiaomin , Zhao Yan , Tan Taizhe , Zhang Yongguang , Chen Zhihong
Published: June 2018

A nanostructured carbon (NSC) material with a hierarchical porous structure is synthesized through the carbonization of a waterweed, namely Echinodorus amazonicus Rataj. The fabricated NSC is used as an electrode material for sulfur of lithium/sulfur (Li/S) batteries. The NSC provides for a high pore volume (0.19 cm3 g−1) and large specific surface area (111.25 m2 g−1). Because of the highly hierarchical porous structure of the NSC material, allowing polysulfides to remain in the carbon framework after cycling, the sulfur/NSC composite exhibits an excellent electrochemical performance.
Jerk Analysis of a Power-Split Hybrid Electric Vehicle Based on a Data-Driven Vehicle Dynamics Model
Authors: Zeng Xiaohua , Cui Haoyong , Song Dafeng , Yang Nannan , Liu Tong , Chen Huiyong , Wang Yinshu , Lei Yulong
Published: June 2018

Given its highly coupled multi-power sources with diverse dynamic response characteristics, the mode transition process of a power-split Hybrid Electric Vehicle (HEV) can easily lead to unanticipated passenger-felt jerks. Moreover, difficulties in parameter estimation, especially power-source dynamic torque estimation, result in new challenges for jerk reduction. These two aspects entangle with each other and constitute a complicated coupling problem which obstructs the realization of a valid anti-jerk method. In this study, a vehicle dynamics model with reference to a data-driven modeling method is first established, integrating a full-time artificial neural network engine dynamic model that can accurately predict engine dynamic torque. Then the essential reason for the occurrence of vehicle jerks in real driving conditions is analyzed. Finally, to smooth the mode transition process, a more practical anti-jerk strategy based on power-source torque changing rate limitation (TCRL) is proposed. Verification studies indicate that the data-driven vehicle dynamics model has enough accuracy to reflect the vehicle dynamic characteristics, and the proposed TCRL strategy could reduce the vehicle jerk by up to 85.8%, without any sacrifice of vehicle performance. This research provides a feasible method for precise modeling of vehicle dynamics and a reference for improving the riding comfort of hybrid electric vehicles.
Study of Power Quality at the Point of Common Coupling of a Low Voltage Grid and a Distributed Generation System of 7.8 kWp in a Tropical Region
Authors: Granja Agustín Valverde , De Souza Teófilo Miguel , Sobrinho Pedro Magalhães , Santos Daniel Felipe Arévalo
Published: June 2018

In this paper we analyze an experimental 1000 kWh/month distributed generation system in a tropical region connected to a point of common coupling in a low voltage grid that was characterized according to NTC 5001. This photovoltaic system has 7.8 kWp and uses 30 polycrystalline silicon-panels of 260 Wp each. Its maximum energy produced was 850 kWh/month, equivalent to 72.65% of the installed capacity. Finally, there was an increase of 2% with respect to the minimum voltage value that was recorded. The voltage unbalance decreases between 3.5 and 70% and voltage harmonics in each line increased by 7% on line U1, 0.8% on U2, 3% on U3 and current harmonics have a 22% increase. Likewise, the total active and reactive power were increased by 58% and 42% respectively, and the thermography study allowed to establish a temperature increase at the point of common coupling of 7.5%. Therefore, it is expected that this paper can serve as a reference for the application of Colombian law 1715 in solar energy.
Exhaust Tuning of an Internal Combustion Engine by the Combined Effects of Variable Exhaust Pipe Diameter and an Exhaust Valve Timing System
Authors: Sawant Pauras , Warstler Michael , Bari Saiful
Published: June 2018

Changes to engine geometry and specifications can produce better torque, power, volumetric efficiency and more. The technique known as wave tuning can lead to better engine torque and power. This paper focuses on increasing the engine torque by improving the exhaust fluid flow through the exhaust manifold. Phasing and intensity of the pressure waves in the exhaust manifold have significant effects on scavenging, valve overlapping and pumping losses. In this research, individual and combined effects of variable exhaust runner diameter and exhaust valve timing on the fluid flow from exhaust of the engine are studied using computer simulation. An engine simulation software, Ricardo Wave, is utilized in this research. The analysis is conducted on a 1-D model of a KTM 510 cc single cylinder, four-stroke Sl engine. The data gathered shows that varying only the exhaust pipe diameter continuously with speed yields an average of 4.23% improvement in torque from the original engine model. However, due to practical constraints, the diameter is limited to vary in three steps (36 mm, 45 mm and 60 mm). This has reduced the average improvement of torque to 3.78%. Varying the valve timing alone gains an average of 1.94% improvement in torque. Varying both the exhaust pipe diameter in three steps and the exhaust valve timing yields an average of 4.69% improvement in torque. This average is conducted over the engine speed ranges from 2000 to 11,000 rpm.
Permanent Magnet Synchronous Motor with Different Rotor Structures for Traction Motor in High Speed Trains
Authors: Torrent Marcel , Perat José Ignacio , Jiménez José Antonio
Published: June 2018

In this work we proposed to study the use of permanent magnet synchronous motors (PMSM) for railway traction in the high-speed trains (HST) of Renfe Operadora (the Spanish national railway operator). Currently, induction motors (IM) are used in AVE classes 102–112 trains, so, the IM used as a traction motor in these trains has been studied and characterized by comparing the results with data provided by Renfe. A PMSM of equivalent power to the IM has been dimensioned, and different electromagnetic structures of the PMSM rotor have been evaluated. The simulation by the finite element method and analysis of the equivalent electrical circuit used in all the motors have been studied to evaluate the performance of the motors in this application. Efficiency is calculated at different operating points due to its impact on the energy consumption of railway traction. The implementation of the PMSM evaluated is recommended, mainly due to the improvements achieved in efficiency as compared with the IM currently used.
Evaluating Adaptive Management Options for Black Ash Forests in the Face of Emerald Ash Borer Invasion
Authors: D’Amato Anthony W. , Palik Brian J. , Slesak Robert A. , Edge Greg , Matula Colleen , Bronson Dustin R.
Published: June 2018

The arrival and spread of emerald ash borer (EAB) across the western Great Lakes region has shifted considerable focus towards developing silvicultural strategies that minimize the impacts of this invasive insect on the structure and functioning of black ash (Fraxinus nigra) wetlands. Early experience with clearcutting in these forests highlighted the risks of losing ash to EAB from these ecosystems, with stands often retrogressing to marsh-like conditions with limited tree cover. Given these experiences and an urgency for increasing resilience to EAB, research efforts began in north-central Minnesota in 2009 followed by additional studies and trials in Michigan and Wisconsin to evaluate the potential for using regeneration harvests in conjunction with planting of replacement species to sustain forested wetland habitats after EAB infestations. Along with these more formal experiments, a number of field trials and demonstrations have been employed by managers across the region to determine effective ways for reducing the vulnerability of black ash forest types to EAB. This paper reviews the results from these recent experiences with managing black ash for resilience to EAB and describes the insights gained on the ecological functioning of these forests and the unique, foundational role played by black ash.
The Performance of Five Willow Cultivars under Different Pedoclimatic Conditions and Rotation Cycles
Authors: Guidi Nissim Werther , Lafleur Benoit , Labrecque Michel
Published: June 2018

A plant’s genotype, their environment, and the interaction between them influence its growth and development. In this study, we investigated the effect of these factors on the growth and biomass yield of willows in short-rotation coppice (SRC) under different harvesting cycles (i.e., two- vs. three-year rotations) in Quebec (Canada). Five of the commercial willow cultivars most common in Quebec, (i.e., Salix × dasyclados Wimm. ‘SV1’, Salix viminalis L. ‘5027’, Salix miyabeana Seeman ‘SX61’, ‘SX64’ and ‘SX67’) were grown in five sites with different pedoclimatic conditions. Yield not only varied significantly according to site and cultivar, but a significant interaction between rotation and site was also detected. Cultivar ‘5027’ showed significantly lower annual biomass yield in both two-year (average 10.8 t ha−1 year−1) and three-year rotation (average 11.2 t ha−1 year−1) compared to other cultivars (15.2 t ha−1 year−1 and 14.6 t ha−1 year−1 in two- and three-year rotation, respectively). Biomass yield also varied significantly with rotation cycle, but the extent of the response depended upon the site. While in some sites the average productivity of all cultivars remained fairly constant under different rotations (i.e., 17.4 vs. 16 t ha−1 year−1 in two- and three-year rotation, respectively), in other cases, biomass yield was higher in the two- than in the three-year rotation or vice versa. Evidence suggests that soil physico-chemical properties are better predictors of willow SRC plantation performance than climate variables.
Effects of Seedling Quality and Family on Performance of Northern Red Oak Seedlings on a Xeric Upland Site
Authors: Pinchot Cornelia C. , Hall Thomas J. , Saxton Arnold M. , Schlarbaum Scott E. , Bailey James K.
Published: June 2018

Cultural practices to develop larger, more robust oak seedlings have been developed, however, the potential improvement conferred by these larger seedlings has received limited testing in the Northeast. We evaluated the effect of seedling size and pedigree on the survival, growth, and competitive ability of northern red oak (Quercus rubra L.) seedlings planted on a xeric site in northeastern Pennsylvania. We planted seedlings from a state tree nursery that represented locally available seedling stock, as well as high-quality seedlings from seven half-sibling families grown following improved nursery protocol. Half-sibling families were split into three size classes based on their root collar diameter and height; large, average, and poor. Eleven years after planting, survival across seedling treatments ranged from 45 percent for locally available seedlings, to 96 percent for one half-sibling family. Two families showed superior growth, survival, and competitive ability compared with the others. Seedling size class conferred moderate height and diameter advantage in four and three of the families, respectively. Initial seedling size was an important variable in models predicting survival, diameter, and dominance (competitive ability). Over time, the relationship between initial diameter and height diminished.
Enhancement of the Efficiency of Bioethanol Production by Saccharomyces cerevisiae via Gradually Batch-Wise and Fed-Batch Increasing the Glucose Concentration
Authors: Chang Yi-Huang , Chang Ku-Shang , Chen Chien-Yu , Hsu Chuan-Liang , Chang Tsan-Chang , Jang Hung-Der
Published: June 2018

High initial glucose concentrations may inhibit glucose utilization and decrease ethanol fermentation efficiency. To minimize substrate inhibition, the effects of feeding yeast with different glucose concentrations on the ethanol production by batch and fed-batch cultures in a 5-L fermentor were investigated. When a batch culture system with Saccharomyces cerevisiae was used for ethanol fermentation with glucose concentrations ranging 10–260 g/L, as a result, 0.2–7.0 g/L biomass and 5.1–115.0 g/L ethanol were obtained. However, substrate inhibition was observed with the initial glucose concentrations greater than 200 g/L in the fermentative media. When a fed-batch culture system (an initial glucose concentration of 180 g/L and total glucose concentration of 260 g/L) was performed, the maximum ethanol concentrations and ethanol yield were significantly higher than those of the batch cultures. The cell biomass, maximum ethanol concentration, and ethanol yields for the fed-batch fermentation cultures were 8.3 g/L, 130.1 g/L and 51% (100% of the theoretical value), respectively. The results indicated that high ethanol concentration and ethanol yield could be achieved by the fed-batch cultures with total glucose concentrations up to 260 g/L.
Potential Use of Bacillus coagulans in the Food Industry
Authors: Konuray Gözde , Erginkaya Zerrin
Published: June 2018

Probiotic microorganisms are generally considered to beneficially affect host health when used in adequate amounts. Although generally used in dairy products, they are also widely used in various commercial food products such as fermented meats, cereals, baby foods, fruit juices, and ice creams. Among lactic acid bacteria, Lactobacillus and Bifidobacterium are the most commonly used bacteria in probiotic foods, but they are not resistant to heat treatment. Probiotic food diversity is expected to be greater with the use of probiotics, which are resistant to heat treatment and gastrointestinal system conditions. Bacillus coagulans (B. coagulans) has recently attracted the attention of researchers and food manufacturers, as it exhibits characteristics of both the Bacillus and Lactobacillus genera. B. coagulans is a spore-forming bacterium which is resistant to high temperatures with its probiotic activity. In addition, a large number of studies have been carried out on the low-cost microbial production of industrially valuable products such as lactic acid and various enzymes of B. coagulans which have been used in food production. In this review, the importance of B. coagulans in food industry is discussed. Moreover, some studies on B. coagulans products and the use of B. coagulans as a probiotic in food products are summarized.
Cardiovascular Health of Construction Workers in Hong Kong: A Cross-Sectional Study
Authors: Chung Joanne , Wong Bonny , Yan Vincent , Chung Louisa , So Henry , Chan Albert
Published: June 2018

Background: Given a shortage of construction workers, it is important to develop strategies to avoid early retirement caused by cardiovascular diseases in Hong Kong. Objectives: (1) to describe the cardiovascular health of construction workers in Hong Kong, (2) to examine the demographic differences in cardiovascular health, and (3) to examine the association between health behaviors and cardiovascular health factors. Methods: 626 registered construction workers were included in the analysis. Blood chemistry, blood pressure, weight, and height were measured. Face-to-face questionnaire interviews for health behaviors were conducted. Results: Approximately two-thirds of the construction workers achieved only three out of the seven “ideal” cardiovascular health metrics. The younger, more educated, and female subjects had better cardiovascular health scores than the older, less educated, and male counterparts. Fish and seafood consumption was associated with (1) ideal weight status and (2) ideal cholesterol level, whereas less soft drink consumption was associated with ideal cholesterol level. Conclusions: The findings highlighted the importance of promoting cardiovascular health in the construction industry. This study provided some insights for future interventions, which should include increasing fish and seafood intake, decreasing soft drink consumption, and enhancing the health literacy amongst older, less educated, and male construction workers.
Comparison of a 10-Year Cumulative Age-Standardized Incidence Rate of Lung Cancer among Metropolitan Cities in Korea (During the 2000–2009 Period): Review of Occupational and Environmental Hazards Associated with Lung Cancer
Authors: Sung Joo Hyun , Sim Chang Sun , Ock Minsu , Oh Inbo , Jeong Kyoung Sook , Yoo Cheolin
Published: June 2018

In Korea, lung cancer is a common cancer, and has the highest mortality rate in both males and females. Approximately 80% of lung cancer is due to smoking, and the remaining cases are known to be due to genetic factors, history of respiratory disease, infection, diet, and occupational and environmental factors. Since the occupational and environmental hazards may differ from region to region, the lung cancer risk may differ too. To identify this, we selected seven metropolitan cities, and compared occupational and environmental hazards. Furthermore, we calculated smoking rate adjusted standardized rate ratio (ratio of 10-year cumulative age-standardized incidence rate of lung cancer during the 2000–2009 period at target region versus reference region) to compare the regional lung cancer risk. The result showed that the emissions and concentrations of air pollutant were higher in high-risk regions, and the risk of lung cancer was significantly elevated in such area. In this study, we simultaneously consider the cumulative incidence, age-standardization and smoking rate adjustment. Therefore, we can conclude that the validity of the finding of this study is higher than that of past studies. In conclusion, the occupational and environmental hazards have an effect on lung cancer.
Complement Activation in Liver Transplantation: Role of Donor Macrosteatosis and Implications in Delayed Graft Function
Authors: Núñez Kelley , Thevenot Paul , Alfadhli Abeer , Cohen Ari
Published: June 2018

The complement system anchors the innate inflammatory response by triggering both cell-mediated and antibody-mediated immune responses against pathogens. The complement system also plays a critical role in sterile tissue injury by responding to damage-associated molecular patterns. The degree and duration of complement activation may be a critical variable controlling the balance between regenerative and destructive inflammation following sterile injury. Recent studies in kidney transplantation suggest that aberrant complement activation may play a significant role in delayed graft function following transplantation, confirming results obtained from rodent models of renal ischemia/reperfusion (I/R) injury. Deactivating the complement cascade through targeting anaphylatoxins (C3a/C5a) might be an effective clinical strategy to dampen reperfusion injury and reduce delayed graft function in liver transplantation. Targeting the complement cascade may be critical in donor livers with mild to moderate steatosis, where elevated lipid burden amplifies stress responses and increases hepatocyte turnover. Steatosis-driven complement activation in the donor liver may also have implications in rejection and thrombolytic complications following transplantation. This review focuses on the roles of complement activation in liver I/R injury, strategies to target complement activation in liver I/R, and potential opportunities to translate these strategies to transplanting donor livers with mild to moderate steatosis.
The Late Stages of Melanogenesis: Exploring the Chemical Facets and the Application Opportunities
Authors: Panzella Lucia , Ebato Atsuko , Napolitano Alessandra , Koike Kenzo
Published: June 2018

In the last decade, the late stages of melanin biosynthesis involving the oxidative polymerization of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) have been extensively investigated. Most of the information derived from a biomimetic approach in which the oxidation of melanogenic indoles was carried out under conditions mimicking those occurring in the biological environment. Characterization of the early oligomers allowed for drawing a structural picture of DHI and DHICA melanins, providing also an interpretative basis for the different properties exhibited by these pigments, e.g., the chromophore and the antioxidant ability. The improved knowledge has opened new perspectives toward the exploitation of the unique chemistry of melanins and its precursors in cosmetic and health care applications. A noticeable example is the development of an innovative hair dyeing system that is based on the marked ease of DHI to give rise to black melanin on air oxidation under slightly alkaline conditions. The advantage of this method for a step-wise coverage of gray hair with a natural shade pigmentation on repeated treatment with a DHI-based formulation with respect to traditional dyes is presented. A variant of DHICA melanin combining solubility in water-miscible organic solvents, an intense chromophore in the UltraViolet-A UV-A region, and a marked antioxidant potency was evaluated as an ingredient for cosmetic formulations.
RNA-Seq Analysis Reveals a Positive Role of HTR2A in Adipogenesis in Yan Yellow Cattle
Authors: Yun Jinyan , Jin Haiguo , Cao Yang , Zhang Lichun , Zhao Yumin , Jin Xin , Yu Yongsheng
Published: June 2018

In this study, we performed high throughput RNA sequencing at the primary bovine preadipocyte (Day-0), mid-differentiation (Day-4), and differentiated adipocyte (Day-9) stages in order to characterize the transcriptional events regulating differentiation and function. The preadipocytes were isolated from subcutaneous fetal bovine adipose tissues and were differentiated into mature adipocytes. The adipogenic characteristics of the adipocytes were detected during various stages of adipogenesis (Day-0, Day-4, and Day-9). We used RNA sequencing (RNA-seq) to investigate a comprehensive transcriptome information of adipocytic differentiation. Compared to the pre-differentiation stage (Day-0), 2510 genes were identified as differentially expressed genes (DEGs) at the mid-differentiation stage (Day-4). We found 2446 DEGs in the mature adipocytic stage relative to the mid-differentiation stage. Some adipogenesis-related transcription factors, CCAAT-enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) were differentially expressed at Day-0, Day-4, and Day-9. We further investigated the adipogenic function of 5-hydroxytryptamine receptor 2A (HTR2A) in adipogenesis. Overexpression of HTR2A stimulated the differentiation of preadipocytes, and knockdown of HTR2A had opposite effects. Furthermore, functional enrichment analysis of DEGs revealed that the PI3K-Akt signaling pathway was the significantly enriched pathway, and HTR2A regulated adipogenesis by activating or inhibiting phosphorylation of phospho-AKT (Ser473). In summary, the present study provides the first comparative transcription of various periods of adipocytes in cattle, which presents a solid foundation for further study into the molecular mechanism of fat deposition and the improvement of beef quality in cattle.
Multiparametric Approach to Arrhythmogenic Cardiomyopathy: Clinical, Instrumental, and Lifestyle Indications
Authors: Stefani Laura , Tosi Benedetta , Galanti Giorgio
Published: June 2018

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder with an autosomal dominant inheritance and incomplete penetrance. It predominantly affects the right ventricle (RV), predisposing to the origin of ventricular arrhythmias and sudden death (SD). The structural basis of the disease consists of the progressive loss of myocardium with fibro-adipose replacement. ARVC is a “desmosomes” disease involving mutations of proteins such as placoglobin, desmoplachine, placophylline, desmoglein, and desmocollin. In the “classical” form, the disease mainly implicates the RV chamber, while the left ventricle (LV) is involved in advanced stages. Genotype-phenotype correlation studies have identified some phenotypic variants characterized by an early participation of the LV, which can proceed in parallel toward the two ventricles (“biventricular” variant) or prevails over the RV (variant to “left dominance”). These data led to the evolution of the initial definition of ARVC, which is currently considered a genetic disease of both ventricles and, therefore, deserves the denomination “arrhythmogenic cardiomyopathy”. Many aspects of diagnosis, treatment, and indications for a correct lifestyle are important in sports medicine. This paper will discuss the clinical management of ARVC, with particular reference to diagnosis, risk stratification, therapy, and indications for physical activity.
Self-Cleaning Ceramic Tiles Produced via Stable Coating of TiO2 Nanoparticles
Authors: Shakeri Amid , Yip Darren , Badv Maryam , Imani Sara M. , Sanjari Mehdi , Didar Tohid F.
Published: June 2018

The high photocatalytic power of TiO2 nanoparticles has drawn great attention in environmental and medical applications. Coating surfaces with these particles enables us to benefit from self-cleaning properties and decomposition of pollutants. In this paper, two strategies have been introduced to coat ceramic tiles with TiO2 nanoparticles, and the self-cleaning effect of the surfaces on degradation of an organic dye under ultraviolent (UV) exposure is investigated. In the first approach, a simple one-step heat treatment method is introduced for coating, and different parameters of the heat treatment process are examined. In the second method, TiO2 nanoparticles are first aminosilanized using (3-Aminopropyl)triethoxysilane (APTES) treatment followed by their covalently attachment onto CO2 plasma treated ceramic tiles via N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS) chemistry. We monitor TiO2 nanoparticle sizes throughout the coating process using dynamic light scattering (DLS) and characterize developed surfaces using X-ray photoelectron spectroscopy (XPS). Moreover, hydrophilicity of the coated surfaces is quantified using a contact angle measurement. It is shown that applying a one-step heat treatment process with the optimum temperature of 200 °C for 5 h results in successful coating of nanoparticles and rapid degradation of dye in a short time. In the second strategy, the APTES treatment creates a stable covalent coating, while the photocatalytic capability of the particles is preserved. The results show that coated ceramic tiles are capable of fully degrading the added dyes under UV exposure in less than 24 h.
Adjusting the Magnetic Properties of ZrO2:Mn Nanocrystals by Changing Hydrothermal Synthesis Conditions
Authors: Kuryliszyn-Kudelska Izabela , Dobrowolski Witold , Arciszewska Monika , Małolepszy Artur , Stobinski Leszek , Minikayev Roman
Published: June 2018

The aim of the present work was to study the magnetic properties of ZrO2(Mn) nanocrystals prepared by microwave-assisted hydrothermal synthesis using three different precursors: KMnO4, MnCl2, and Mn(NO3)2. The structural characterization was performed by means of X-ray diffraction. The morphology of the samples was studied by using STEM microscopy. The magnetic properties were studied by means of alternating current (AC) susceptibility (at a small AC magnetic field with amplitude not exceeding 5 Oe) and direct current (DC) magnetization (up to 9 T). All of the samples demonstrated Curie–Weiss behavior at higher temperatures with negative values of the Curie–Weiss temperature θ. It was shown that the conditions of the synthesis, e.g., pH and the type of precursor, can be adjusted to decrease the value of the Curie–Weiss temperature and reduce antiferromagnetic interactions.
Immune factors in human embryo culture and their significance
Authors: Čerkienė Živilė , Eidukaitė Audronė , Usonienė Audronė
Published: June 2018

There is increasing evidence that human development before implantation is regulated by embryonically and maternally derived growth factors. The “regulators” of embryonic origin such as soluble human leukocyte antigen G, platelet-activating factor, Th1/Th2 cytokines, insulinlike growth factor, epidermal growth factor, transforming growth factor α, colony-stimulating factor, platelet-derived growth factor may be used as indicators of embryo viability and implantation potential. The data prove the infl uence of growth factors on the development and growth of preimplantation embryos. Though there is a lot of research in the field of biomarkers during folliculogenesis and maternal-fetal interface, only few of them deal with regulators derived from embryonic cells to the cultivation medium. The aim of our study was to summarize the research dealing with immune markers produced by embryos in vitro and to estimate their impact on the cell growth, viability and implantation potential.
Tigecycline – how powerful is it in the fight against antibiotic-resistant bacteria?
Authors: Šeputienė Vaida , Povilonis Justas , Armalytė Julija , Sužiedėlis Kęstutis , Pavilonis Alvydas , Sužiedėlienė Edita
Published: June 2018

Tigecycline is a semisynthetic analogue of earlier tetracyclines and represents the first member of a novel class of antimicrobials – glycylcyclines – recently approved for clinical use. It is active against a broad range of gram-negative and gram-positive bacterial species including clinically important multidrug-resistant nosocomial and community-acquired bacterial pathogens. The exact molecular basis of tigecycline action is not clear at present, although similarly to the tetracyclines, it has been shown to inhibit the translation elongation step by binding to the ribosome 30S subunit and preventing aminoacylated tRNAs to accommodate in the ribosomal A site. Importantly, tigecycline overcomes the action of ribosomal protection proteins and is not a substrate for tetracycline efflux pumps of most bacteria – well-known and prevalent cellular mechanisms of microbial tetracycline resistance. The present review summarizes current knowledge on the molecular mechanism of the tigecycline action, antibacterial activity against various bacteria, clinical application, development of resistance to glycylcyclines.
Secondary thrombosis of the left internal carotid artery caused by a motor vehicle accident: a radiological case
Authors: Randakevičienė Goda , Gleiznienė Rymantė , Rastenytė Daiva , Lukoševičius Saulius
Published: June 2018

rare case of occlusion of the internal carotid artery following a motor vehicle accident in a 34-year-old female victim who initially presented with clear consciousness and had normal computed tomogram of the brain is reported. Seven hours after the accident, the patient was unexpectedly diagnosed with the left hemisphere infarction, and two days later, she suffered from right hemiplegia and coma. The follow-up brain computed tomography scan showed an acute infarction of the left hemisphere of the cerebrum and severe cerebral edema. Anticoagulation therapy was administered, and emergency craniotomy for brain decompression was carried out. After 3.5 months, she was discharged and underwent regular follow-up in the outpatient department. Four years after the motor vehicle accident, the patient had intact awareness, was functionally independent, but remained with motor aphasia, right hand paralysis, and right leg paresis.
Meningovascular neurosyphilis: a report of stroke in a young adult
Authors: Vaitkus Antanas , Krasauskaitė Eglė , Urbonavičiūtė Inga
Published: June 2018

A young adult patient with meningovascular neurosyphilis in the form of acute ischemic stroke with right hemiparesis and speech disturbance is reported. CT scan showed features of ischemic infarct and extensive laboratory studies were made before the diagnosis ultimately was revealed. Such cases could result in confusion for the clinician, and high index of clinical suspicion of this condition is required since syphilis is not routinely tested, as routine screening is seen to be of low diagnostic yield. As clinical practice indicates, it remains a difficult problem approaching diagnosis of neurosyphilis, and this is achieved through exclusion of neurosyphilis as a clinical possibility.
Influence of CO2 Shielding Gas on High Power Fiber Laser Welding Performance
Authors: Li Shichun , Xu Wei , Su Fei , Deng Hui , Deng Zhaohui
Published: June 2018

The weldabilities were investigated during 10 kW high-power fiber laser welding of 304 stainless steel with the shielding gases of 100% Ar, 80% Ar + 20% CO2 and 100% CO2, respectively. As the proportion of CO2 in shielding gas increased from 0% to 20% then to 100%, the molten pool became unstable and the optional parameter range for obtaining a good weld appearance became narrow. The defocused distance was more negative during the CO2 shielded welding, where the weld joint without apparent defect, the maximum penetration, and a necking of weld width were formed. Porosity has been suppressed and eliminated in the CO2 shielded weld joint. The highest microhardness was obtained from the Ar + CO2 shielded weld joint, because the denser δ-ferrite appeared in the Ar + CO2 shielded weld joint. The microhardness of CO2 shielded weld joints was relative low because of the oxidation of the elements of C, Si, Mn, and Cr, which reduces the solid solution hardening tendency during the welding process.
Prediction of Resistance Spot Weld Quality of 780 MPa Grade Steel Using Adaptive Resonance Theory Artificial Neural Networks
Authors: Hwang Insung , Yun Hyeonsang , Yoon Jinyoung , Kang Munjin , Kim Dongcheol , Kim Young-Min
Published: June 2018

In this study, the weld quality of 780 MPa grade dual phase (DP) steel with 1.0 mm thickness was predicted using adaptive resonance theory (ART) artificial neural networks. The welding voltage and current signals measured during resistance spot welding (RSW) were used as the input layer data, and the tensile shear strength, nugget size, and fracture shape of the weld were used as the output layer data. The learning was performed by the ART artificial neural networks using the input layer and output layer data, and the patterns of learning result were classified by the setting of vigilance parameter, ρ. When the vigilance parameter is 0.8, the best-predicted results were obtained for the tensile shear strength, nugget size, and fracture shape of welds.
Membrane Fatty Acid Composition and Cell Surface Hydrophobicity of Marine Hydrocarbonoclastic Alcanivorax borkumensis SK2 Grown on Diesel, Biodiesel and Rapeseed Oil as Carbon Sources
Authors: Konieczna Maria , Olzog Martin , Naether Daniela , Chrzanowski Łukasz , Heipieper Hermann
Published: June 2018

The marine hydrocarbonoclastic bacterium Alcanivorax borkumensis is well known for its ability to successfully degrade various mixtures of n-alkanes occurring in marine oil spills. For effective growth on these compounds, the bacteria possess the unique capability not only to incorporate but also to modify fatty intermediates derived from the alkane degradation pathway. High efficiency of both these processes provides better competitiveness for a single bacteria species among hydrocarbon degraders. To examine the efficiency of A. borkumensis to cope with different sources of fatty acid intermediates, we studied the growth rates and membrane fatty acid patterns of this bacterium cultivated on diesel, biodiesel and rapeseed oil as carbon and energy source. Obtained results revealed significant differences in both parameters depending on growth substrate. Highest growth rates were observed with biodiesel, while growth rates on rapeseed oil and diesel were lower than on the standard reference compound (hexadecane). The most remarkable observation is that cells grown on rapeseed oil, biodiesel, and diesel showed significant amounts of the two polyunsaturated fatty acids linoleic acid and linolenic acid in their membrane. By direct incorporation of these external fatty acids, the bacteria save energy allowing them to degrade those pollutants in a more efficient way. Such fast adaptation may increase resilience of A. borkumensis and allow them to strive and maintain populations in more complex hydrocarbon degrading microbial communities.
Impact of Dietary Cholesterol on the Pathophysiology of Infectious and Autoimmune Disease
Authors: Andersen Catherine J.
Published: June 2018

Cellular cholesterol metabolism, lipid raft formation, and lipoprotein interactions contribute to the regulation of immune-mediated inflammation and response to pathogens. Lipid pathways have been implicated in the pathogenesis of bacterial and viral infections, whereas altered lipid metabolism may contribute to immune dysfunction in autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Interestingly, dietary cholesterol may exert protective or detrimental effects on risk, progression, and treatment of different infectious and autoimmune diseases, although current findings suggest that these effects are variable across populations and different diseases. Research evaluating the effects of dietary cholesterol, often provided by eggs or as a component of Western-style diets, demonstrates that cholesterol-rich dietary patterns affect markers of immune inflammation and cellular cholesterol metabolism, while additionally modulating lipoprotein profiles and functional properties of HDL. Further, cholesterol-rich diets appear to differentially impact immunomodulatory lipid pathways across human populations of variable metabolic status, suggesting that these complex mechanisms may underlie the relationship between dietary cholesterol and immunity. Given the Dietary Guidelines for Americans 2015–2020 revision to no longer include limitations on dietary cholesterol, evaluation of dietary cholesterol recommendations beyond the context of cardiovascular disease risk is particularly timely. This review provides a comprehensive and comparative analysis of significant and controversial studies on the role of dietary cholesterol and lipid metabolism in the pathophysiology of infectious disease and autoimmune disorders, highlighting the need for further investigation in this developing area of research.
Validation of Different Nutritional Assessment Tools in Predicting Prognosis of Patients with Soft Tissue Spindle-Cell Sarcomas
Authors: Sasaki Hiromi , Nagano Satoshi , Komiya Setsuro , Taniguchi Noboru , Setoguchi Takao
Published: June 2018

Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer. Binomial logistic regression analysis showed that male sex, older age at diagnosis, higher GPS, higher stage, and unresectable STS were risk factors for death within a year of diagnosis. Overall survival was evaluated by Cox proportional hazards models, which correlated higher NLR, higher PLR, larger maximum diameter of tumor, higher stage, and unresectable STS with poor prognosis. We next examined prognostic factors in the 93 patients with resectable STS, and found male sex, higher GPS, and higher stage were correlated with poor prognosis in these patients. Our findings suggest that GPS, NLR, and PLR are simple predictors of outcome in patients with STS. Nutritional therapies might improve their GPS and prognosis.
An Academic Obituary of Eric McLuhan
Authors: Logan Robert K.
Published: June 2018

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pH-Responsive Hybrid Hydrogels as Antibacterial and Drug Delivery Systems
Authors: Sattari Shabnam , Dadkhah Tehrani Abbas , Adeli Mohsen
Published: June 2018

This study describes the design and synthesis of organic–inorganic hybrid hydrogels based on an interpenetrating polymer network (IPN) composed of polyaspartic acid crosslinked by graphene nanosheets as the primary network and poly(acrylamide-co-acrylic acid) as the secondary network. Silver, copper oxide, and zinc oxide nanoparticles were formed within the gel matrix, and the obtained hydrogel was applied to a load and controlled release of curcumin. The loading of curcumin and the release of this drug from the gels depended on the nanoparticle’s (NP’s) content of hydrogels as well as the pH of the medium. The synthesized hydrogels showed antibacterial activity against E. coli and S. aureus bacteria. The ability of the synthesized hydrogels to incapacitate bacteria and their loading capacity and controlled release of curcumin qualify them for future therapies such as wound-dressing applications.