bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical complications of myocardial infarction: basic aspects of pathogenesis and approaches to surgical treatment
Authors: Shengelia L. D. , Fatulaev Z. F. , Donakanyan S. A. , Konshina M. O. , Panagov Z. G. , Bockeria L. A.
Published: July 2023

Ischemic heart disease is a leading cause of mortality of the adult population. The most mortality of all forms of ischemic heart disease is occurred with development of myocardial infarction. Meanwhile, the direct cause of death are complications of myocardial infarction. Since the advent of catheter-based and surgical reperfusion, there has been a significant decrease in the frequency of these complications. However, patients with large myocardial infarctions or those who do not receive necessary revascularization in time remain at risk of mechanical complications of acute myocardial infarction. The most common mechanical complications are rupture of the papillary muscles of the mitral valve and acute mitral regurgitation, interventricular septal defect, forming of aneurysms and pseudoaneurysms, and free-wall rupture. Although these complications are rare, their prognosis is unfavourable and is associated with high mortality at the prehospital and hospital stage. Early diagnosis, determination of optimal treatment tactics are crucial for increasing the survival rate of patients.
Differentiation of stakeholders in the economic ecosystem of the region
Authors: POPOV Evgenii V. , SIMONOVA Viktoriya L. , KAVETSKII Sergei A.
Published: July 2023

Subject. This article discusses the problems of the development of an innovative economy.
Objectives. The article aims to determine the role of various public institutions in improving the investment attractiveness of Russian regions.
Methods. For the study, we used the systems analysis.
Results. The article describes the ways, which the main elements of the region's ecosystem, such as municipalities, educational and scientific institutions, the media and business use to make a certain contribution to the formation of the gross regional product.
Conclusions. Creating an innovative economy requires taking into account the interests of different social groups.
“Where ladies are so scarce we have to muster in full”: Sophie Porter’s Account of Over–Wintering at Herschel Island, 1894-1895
Authors: Lackenbauer P. Whitney
Published: July 2023

Sophie E. Porter’s account offers colourful insights into the life of the whaling community over–wintering at Herschel Island (Qikiqtaruk) in the mid–1890s. Porter lived on board the whaling ship Jesse H. Freeman in the winterized quarters prepared for her husband, but her full social schedule meant that the ship did not keep her captive. The excerpts transcribed, reproduced, and introduced in this commentary span the period from 19 August 1894 (when Jessie H. Freeman dropped anchor off the sand spit at Herschel) to Victoria Day (24 May) 1895. Porter’s account offers rare insights into how women and other members of the diverse Herschel Island community negotiated gender, race, and class positions and coped with life in this remote Arctic outpost.

Le récit de Sophie E. Porter offre un aperçu imagé de la vie de la communauté baleinière qui a passé l’hiver à l’île Herschel (Qikiqtaruk) au milieu des années 1890. Porter vivait à bord du baleinier Jesse H. Freeman dans les locaux aménagés pour l’hiver préparés pour son mari, mais son calendrier d’activités sociales était chargé même si elle était à bord d’un navire. Les extraits transcrits, reproduits et présentés dans cet exposé couvrent la période du 19 août 1894 (lorsque le Jessie H. Freeman a jeté l’ancre près de la flèche de sable à l’île Herschel) à la fête de la Reine du 24 mai 1895. Le récit de Porter offre un regard unique sur la façon dont les femmes et les autres membres de la communauté hétérogène de l’île Herschel déterminaient leurs positions de genre, de race et de classe et faisaient face aux difficultés de la vie dans cet avant–poste isolé de l’Arctique.
Of Landscapes and Animals: An Ecosophical Analysis of Pagu Folktales
Authors: Dewi Novita
Published: July 2023

Spoken by a few members of the Pagu ethnic group in North Halmahera province, Pagu is one among endangered languages in Indonesia worth saving from extinction (Perangin-Angin, 2018). This study examines the preservation of Pagu by caring for the literary wealth in the language, i.e., folktales. Using Ecosophy as a theoretical trajectory, the analysis of the five Pagu folktales studied show that (1) Two creation fables are anthropocentric because the intention is to teach and impart values to people; (2) The other two are morality tales calling for peopleâ€™s care for and attention to the environment and all the ecosystems which have so far supported peopleâ€™s life. This study concludes that not only do traditional tales enhance language research and character education, they also deliver transformative power to call for an ethic of care â€“ caring for the language and caring for the environment. Thus, the maintenance of the local culture, such as folktales, complements the language preservation efforts.Â
Vascular Health: The Power of Implantable Wireless Electronics
Authors: Herbert Robert , Yeo Woon-Hong
Published: July 2023

The continuous monitoring of vascular health achievable by implantable electronics can offer improved disease diagnosis and treatments. We developed a wireless nanomembrane system consisting of a smart stent and soft sensors to enable simultaneous monitoring of blood pressure, blood flow, and pulse rate.
Impact of individualised homoeopathy in plaque psoriasis – A case report
Authors: Sahoo Sanjib , Mukherjee Suranjana , Bhattacharya Soumya , Mondal Mahadev , Nayak Chintamani
Published: July 2023

Psoriasis, a papulosquamous skin lesion, is one of the most common autoimmune multisystemic disorders. Beyond the physical dimension of the disorder, it has a profound effect on the emotional and psychological faculty of the patient which can result in poor self-esteem, stigmatisation, and a stressful mental state affecting social-functioning and interpersonal relationships. Homoeopathy being a holistic science having a bio-psychosocial approach can manage cases of psoriasis effectively. A 43-year-old female attended the National Institute of Homoeopathy Outpatient Department with complaints of multiple circumscribed skin lesions over the scalp, back and extremities for 25 years. After a thorough evaluation of the case, the Arsenicum album was prescribed in 50 millesimal potency. There was a steady clinical improvement in the case and a reduction in the psoriasis area and severity index score. After 6 months of observation following the disappearance of symptoms, there was absolutely no recurrence of psoriatic skin lesions. This case report shows favourable outcomes with individualised homoeopathic treatment. However, a conclusive judgement regarding the efficacy of homoeopathic medications in treating plaque psoriasis cannot be made based on a single case. To evaluate the efficacy of individualised homoeopathic medicine, a large-scale randomised study is suggested.
Impact of COVID-19 on the occurrence and exacerbation of cutaneous forms of lupus erythematosus: A review
Authors: Mikheeva Eleonora S. , Golubeva Iuliia M. , Radionova Ekaterina E. , Zhukova Olga V. , Korsunskaya Irina M.
Published: July 2023

The article addresses the impact of the new coronavirus infection on the occurrence of cutaneous forms of lupus erythematosus (LE). Since the beginning of the COVID-19 pandemic, there has been an increase in the incidence of cutaneous LE worldwide, the emergence of new cases, and exacerbation and aggravation of the severity of existing ones. The pathogenesis of cutaneous LE, and the role of viral infections in its occurrence, mainly COVID-19, is reviewed. The need for the SARS-CoV-2 vaccination and its potential as a possible trigger is described. It is necessary to note the importance of clinicians in diagnosing LE since it is essential for the dermatologist to know the features of its course and be able to suspect and diagnose even the rarest forms of this disease. Proper awareness and correct diagnosis determine the optimal drug therapy and patient health in the future.
The first cases of using targeted therapy for secondary progressive multiple sclerosis in Russia. Case report
Authors: Korobko Denis S. , Arkhipov Ivan Ie. , Prokaeva Anna I. , Tret'iakova Ekaterina V.
Published: July 2023

Siponimod (Kajendra) is a sphingosine-1-phosphate receptor modulator type 1 and 5 (S1P1,5), the first targeted agent for the treatment of patients with secondary progressive multiple sclerosis, both with and without exacerbations and/or activity according to magnetic resonance imaging. The drug was approved in Russia at the end of December 2020. The efficacy of siponimod was confirmed in EXPAND study, a large, randomized, double-blind phase III clinical study. This article presents three clinical cases of patients with secondary progressive multiple sclerosis from the practice of specialists of the Novosibirsk Center for Multiple Sclerosis and Other Autoimmune Diseases of the Nervous System with an analysis of patients selection for siponimod treatment and an assessment of the therapy effectiveness.
Extracellular matrix sensing via modulation of orientational order of integrins and F-actin in focal adhesions
Authors: Grudtsyna Valeriia , Packirisamy Swathi , Bidone Tamara C , Swaminathan Vinay
Published: July 2023

Specificity of cellular responses to distinct cues from the ECM requires precise and sensitive decoding of physical information. However, how known mechanisms of mechanosensing like force-dependent catch bonds and conformational changes in FA proteins can confer that this sensitivity is not known. Using polarization microscopy and computational modeling, we identify dynamic changes in an orientational order of FA proteins as a molecular organizational mechanism that can fine-tune cell sensitivity to the ECM. We find that αV integrins and F-actin show precise changes in the orientational order in an ECM-mediated integrin activation-dependent manner. These changes are sensitive to ECM density and are regulated independent of myosin-II activity though contractility can enhance this sensitivity. A molecular-clutch model demonstrates that the orientational order of integrin–ECM binding coupled to directional catch bonds can capture cellular responses to changes in ECM density. This mechanism also captures decoupling of ECM density sensing from stiffness sensing thus elucidating specificity. Taken together, our results suggest relative geometric organization of FA molecules as an important molecular architectural feature and regulator of mechanotransduction.
Competitive, adaptive variety of soft winter wheat of universal type Stepnyachka 1
Authors: Kovtun Viktor Ivanovich , Kovtun Liudmila Nikolaevna
Published: July 2023

The article presents the purpose, methods and results of studying a new variety of soft winter wheat Stepnyachka 1. The new variety was created using modern methods of traditional (classical), as well as haploid and marker breeding. The article presents a botanical description of a new variety of soft winter wheat, a variety of lutescens. Stepnyachka 1 is a productive variety, the average grain yield for four years of study (2019–2022) was 9.42 t/ha, which is 1.51 t/ha higher than the Grom standard, the maximum yield is 12.80 t/ha. Despite the longer stem in comparison with the semi-dwarf varieties Grom, the new genotype is highly resistant to lodging, due to the high strength of the stem. The variety has high indicators of phylogenetic resistance to low temperatures, which allow it to winter with guarantee in regions with harsh winter and spring conditions. Stepnyachka 1 has a high field resistance to major diseases (various types of rust, dusty smut, septoria, pyrenophorosis, fusarium, yellow dwarf barley virus). In terms of grain quality, it is not inferior to the Grom standard, which is included in the list of valuable wheat of the Russian Federation.
Pembuatan Karbon Aktif dari Kulit dalam Biji Kopi (Endocarp) Menggunakan Aktivator Koh dan H3PO4
Authors: Rizki Ridha Gebrina , Bahri Syamsul , Ginting Zainuddin
Published: July 2023

Karbon aktif adalah suatu bahan yang mengandung unsur karbon 85-95% dan merupakan padatan berpori. Karbon aktif ini merupakan hasil pemanasan bahan yang mengandung karbon pada suhu tinggi tetapi tidak teroksidasi. Pada penelitian ini bahan yang digunakan adalah Kulit Dalam Biji Kopi dan aktivatornya berupa KOH dan H3PO4. Adapun tujuan penelitian ini untuk mengkaji pembuatan Karbon Aktif dari Kulit Dalam Biji Kopi dengan Variasi Konsentrasi dan Jenis aktifator yang berbeda, menganalisa kadar air, kadar abu, kadar karbon terikat, dan daya serap terhadap larutan I2 pada Karbon aktif. Penelitian ini dilakukan dengan aktivator KOH dan H3PO4 masing-masing 1N, 2N, 3N, dan 4N. Berdasarkan hasil penelitian diperoleh karbon aktif dengan kadar air terendah 1,4% pada aktivator H3PO4, kadar abu terendah 3,6% pada H3PO4, kadar karbon terikat tertinggi 73,0%, dan daya serap terhadap I2 tertinggi 1699,2%. Dari data yang diperoleh jenis aktivator H3PO4 merupakan aktivator terbaik.
PRODUCTION OF BIOETHANOL FROM BANANA PEEL (Musa paradisiaca l.) USING SULFURIC ACID CATALYST
Authors: Zulnazri Zulnazri , Maulana Arif , Muarif Agam , Sylvia Novy , Dewi Rozanna
Published: July 2023

.Bioethanol is a pure alcoholic compound consisting of ethanol and is produced through a biomass fermentation process with the help of microorganisms.  Making bioethanol can be done using plants that contain starch, carbohydrates, glucose, and cellulose. One option is kepok banana peels.  Utilization of kepok banana peels can increase the variety of raw materials for bioethanol production which are cost-effective and easy to obtain.  This research has been done before, what has never been done is the manufacture of bioethanol using various catalysts H2SO4, hydrolysis temperature and fermentation time.  This research method uses hydrolysis, fermentation and distillation with variations in hydrolysis temperatures of 80°C, 90°C and 100°C, variations in catalyst concentration H2SO4 1 M, 2 M, 3 M with fermentation times of 5, 7, 9 days. Results of this study  the highest yield and density were obtained at the hydrolysis temperature of 90°C, the catalyst concentration of 3 M H2SO4 with a fermentation time of 9 days was 5.0432% and 0.8346 gr/ml, and the highest bioethanol content was at the hydrolysis temperature of 90°C, the catalyst concentration  2 M H2SO4 with 9 days fermentation time of 0.2884%.  The size of a grade is influenced by the length of time of fermentation and the amount of catalyst given.  The density value of the bioethanol obtained meets the Indonesian National Standard.  The results of the GC (Gas-Chromatography) test based on the highest glucose content and fermentation time at each temperature variation showed that the bioethanol content with a glucose content of 5.2%, 12.2% and 14.1% respectively at a hydrolysis temperature of 80°C  , 90°C and 100°C with catalyst concentration H2SO4 3 M and a fermentation time of 9 days, namely 1.783%, 4.024% and 5.030%.  The greater the catalytic agent used, the greater the level of glucose produced and the longer the fermentation period given, the more optimal the product will be.
Efecto del aceite esencial de orégano y sus fracciones concentradas en el crecimiento de Aspergillus brasiliensis (niger)
Authors: Cazares-Rodríguez A.G. , Rodríguez-Rodríguez J. , Sánchez-García E. , De Lara-Novella J. , García-Alanís K. , Leos-Rivas C. , Castillo-Hernández S.
Published: July 2023

La inocuidad de los alimentos es una necesidad crítica a nivel mundial. Algunos hongos deteriorantes como Aspergillus brasilienis (niger) producen micotoxinas en las materias primas (granos principalmente) y esto llega al alimento terminado, provocando complicaciones en la salud. La incidencia de brotes en los alimentos obliga a investigar nuevos métodos para la conservación alimentaria, por otro lado, también existe una gran demanda de productos naturales, es por esto, que el uso de aceites esenciales como conservadores naturales cobra especial importancia en la industria alimenticia, ya que éstos son reconocidos como seguros (GRAS) para ser usados en alimentos. Los aceites esenciales de orégano constituyen una alternativa como potenciales agentes antioxidantes y antimicrobianos prolongando la vida útil. El objetivo del presente estudio fue evaluar los efectos de las fracciones concentradas de orégano sobre el crecimiento de A. brasiliensis (niger). Se realizaron pruebas de difusión en disco, determinación de la concentración mínima inhibitoria (CMI), concentración mínima fungicida (CMF) y evaluación morfológica del hongo a concentraciones menores a la CMF. Los resultados muestran una actividad antimicrobiana con halos de inhibición en rangos de 3.6-5.8 cm. La CMI y CMF mostraron rangos de 6 a 600 ppm, mientras que la evaluación morfológica, evidenció una alta inhibición de la conidiogénesis.
Carotenoides en ate de vegetales
Authors: Calvo-Carrillo M.C. , Coronel F. , López O.X.
Published: July 2023

Por el tipo de alimentación y la calidad de vida se han incrementado enfermedades del crónico degenerativas. Algunas asociadas a la acción de radicales libres y especies reactivas de oxígeno. Se ha sugerido el incremento en el consumo de antioxidantes a través de los alimentos. Son los vegetales los insumos con el mayor contenido y variedad de estos fitoquímicos. Ante la diversidad de técnicas artesanales que están disponibles en la elaboración de productos regionales, se propone como objetivo combinar vegetales como fuente de carotenoides en la elaboración de un Ate rompiendo con la tradición de sólo hacerlo con frutas convencionales. Se utilizaron papaya, zanahoria, jitomate y jugo de mandarina para hacer 4 mezclas que se adicionaron con pectina, sacarosa y ácido cítrico. Se aplicó el procedimiento tradicional para obtener el ate. Se cuantificaron 5 carotenoides (luteína, zeaxantina, criptoxantina, β-caroteno y licopeno) tanto en la materia prima como en los ates desarrollados. Los ates fueron evaluados sensorialmente con una prueba de preferencia. Los resultados indicaron que no hubo diferencia entre ellos. Se concluye que los ates elaborados con vegetales, a pesar del proceso térmico empleado, retuvieron los carotenoides y las combinaciones usadas fueron aceptadas por los panelistas.
Evaluación de las propiedades fisicoquímicas y sensoriales de Nuggets de conejo usando harina de Okara de garbanzo
Authors: Carbajal-Padilla D. , Escobar-Escobar L.P. , Fernández-Villanueva G. , Ochoa-Montes D.A. , Sosa-Morales M.E. , Gómez-Salazar J.A.
Published: July 2023

La carne de conejo destaca por sus potenciales características nutritivas, para una sociedad que demanda carnes con menos grasa y más proteicas. La Okara es un subproducto de la producción de bebidas vegetales de gran calidad nutricional y tecnológica que puede ser utilizada para elaborar gran diversidad de productos alimenticios. El objetivo del presente trabajo fue elaborar un nugget con carne de conejo y Okara de garbanzo seca (OGS) para evaluar sus atributos fisicoquímicos y su aceptación sensorial. La metodología se basó en formulaciones con distintos porcentajes de carne de conejo y de OGS en Nuggets precocidos y tostados, a estos se les determino color, pH, textura y se realizó un análisis sensorial donde se comparó con un producto comercial. Los resultados obtenidos para color y textura en cada formulación no presentaron efectos significativos (P<0.05). En el análisis sensorial se encontró que la muestra no tiene diferencias significativas con la muestra comercial. Asimismo, la obtención de un nugget con carne de conejo y OGS puede mejorar la aceptación sensorial de este tipo de carne.
Análisis fitoquímico y evaluación antidiabética de los palmitos de Chamaedorea tepejilote
Authors: Fernández-Avalos S. , Bernardino-Nicanor A. , Teniente-Martínez G. , Juárez-Goiz M.S. , González-Cruz L.
Published: July 2023

En México el tepejilote es utilizado como alimento tradicional en el cual es consumido mediante tratamientos térmicos, sin embargo, algunas personas utilizan el tepejilote con fines farmacológicos para contrarrestar patologías como la diabetes, uno de los mecanismos importantes para la disminución de la glucosa postprandial en pacientes diabéticos es la inhibición de la enzima α-amilasa, no obstante diversos estudios científicos han demostrado que ciertos metabolitos secundarios de las plantas medicinales pueden servir como inhibidores enzimáticos. Por lo tanto, en el presente trabajo se realizó un análisis fitoquímico de los extractos acuosos y hexánicos de los palmitos de tepejilote tratados térmicamente y sin tratamiento, se evaluó su participación en la inhibición de la enzima α-amilasa, en el cual observamos que los metabolitos secundarios como flavonoides, cumarinas y quinonas son más abundantes en las muestras tratadas térmicamente, así como el contenido de fenoles totales es menor en la muestra sin tratamiento. Por otra parte, los extractos acuosos mostraron una inhibición de la enzima α-amilasa, siendo las muestras tratadas térmicamente las que mostraron un mayor efecto inhibitorio al compararse con la muestra en crudo (38.67% de inhibición de α-amilasa).
Obtención de aislados e hidrolizados proteicos de grillo (Acheta domesticus) y evaluación de su actividad antioxidante
Authors: Sosa-Flores M.L. , García-Hernández D.G. , Amaya-Guerra C.A. , Bautista-Villarreal M. , González-Luna A.R.
Published: July 2023

La harina desengrasada de A. domesticus posee una concentración proteica del 61.3%. Se evaluó la concentración proteica de los aislados proteicos de A. domesticus utilizando el método de Kjeldahl, obteniendo como resultado un 71.7% de proteínas. Los hidrolizados proteicos de A. domesticus se obtuvieron utilizando la enzima Alcalasa a 0.22 UA/g obteniendo un contenido proteico de 57.97 mg/mL. Para evaluar la actividad antioxidante se realizó el ensayo que evalúa la capacidad para secuestrar el radical DPPH de acuerdo con la metodología descrita por Gómez et al., (2013), por espectrofotometría a 517 nm, empleando un lector de microplacas de 96 pocillos; se evaluaron los hidrolizados proteicos en los tiempos 0, 15, 30, 45, y 60 minutos, utilizando distintas concentraciones proteicas (1, 2, 3, 4, y 5 mg/mL), así como una prueba para el control positivo con Trolox a distintas concentraciones (100, 200, 300, 400 y 500 µg/mL). La actividad antioxidante se observó levemente favorecida con un 31 al 52% de inhibición para el tiempo 0 (min) y 14 al 38% para el tiempo 15 (min), esto en comparación con el control positivo Trollox el cual tuvo un porcentaje de inhibición mayor al 80%.
Obtaining emulsions of furanocoumarins from Sosnowsky’s hogweed and in vitro assessment of their phototoxic effect
Authors: Shlyapkina V. I. , Kulikov O. A. , Brodovskaya E. P. , Al-khadj Aioub A. M. , Ageev V. P. , Pyataev N. A.
Published: July 2023

Background. Furanocoumarin-based drugs are used for photochemotherapy of various diseases. Sosnovsky’s hogweed can be an available source of furanocoumarins for the development of drugs.The aim of the study. To obtain stable emulsions containing furanocoumarins from Sosnowski’s hogweed and to evaluate their photocytotoxicity.Materials and methods. To obtain the emulsions, furanocoumarins were extracted with chloroform from the sap of the aerial part of the Sosnowski’s hogweed. The chloroform extract was clarified by silica gel gradient column chromatography. The extractive fraction containing furanocoumarins was analyzed by high performance liquid chromatography with ultraviolet (UV) detection. An extract with a high content of 8-methoxypsoralen was used to prepare two types of emulsions. The extract was dissolved in peach oil and emulsified in water with tween-80 (emulsion No. 1) and in an aqueous glycerin solution with lecithin (emulsion No. 2).The emulsions were tested for dark and photo-induced toxicity for human lung fibroblasts. The dose of UV radiation for the photoactivation of furanocoumarins was 9 J/cm2. A solution of chlorine e6 was used as a comparison photosensitizer.Results. The obtained emulsions contained 1 mg/ml 8-methoxypsoralen. Both emulsions were homogeneous at macro- and microscopic visualization, remained stable when stored under various temperature conditions for 14 days. Emulsion No. 2 did not show dark toxicity and caused a statistically significant inhibition of cell viability under UV irradiation at a concentration of 12.5–31.3 µg/mL. Emulsion No. 1 had a toxic effect on cells regardless of UV irradiation due to the content of tween-80. According to fluorescent microscopy, the phototoxic effect of emulsion No. 2 was manifested mainly due to apoptosis, in contrast to the effect of chlorine e6, in which there were more pronounced signs of cell necrosis.Conclusion. The developed experimental emulsions of furanocoumarins from Sosnovski’s hogweed are an example of promising medicinal photosensitizers of plant origin for phototherapy of various dermatological and oncological diseases.
Modification of low-density lipoproteins by low molecular weight carbonyl products of free-radical oxidation of lipids and carbohydrates plays a key role in atherosclerotic lesion of the vascular wall and in endothelial dysfunction
Authors: Lankin V. Z. , Tikhaze A. K. , Kosach V. Ya. , Konovalova G. G. , Kudryashova A. V.
Published: July 2023

The review presents evidence of the participation of low-density lipoproteins (LDL) modified by low molecular weight dicarbonyl compounds formed during freeradical oxidation of lipids (malondialdehyde) and carbohydrates in the development of endothelial dysfunction and atherosclerotic vascular lesions. The authors believe that it is they, and not oxidized (hydroperoxide-containing) LDL, that are the main factors of pathogenesis. The role of dicarbonyl-modified LDL in LOX-1 dependent induction of processes leading to the development of endothelial dysfunction is discussed. The results of studies proving that damage to the glycocalyx (a layer of macromolecules that prevent the development of endothelial dysfunction) covering the luminal surface of the endothelium is caused by hyperproduction of reactive oxygen species. Ways of pharmacological correction of free-radical oxidation processes are discussed, due to which inhibition of atherogenesis and diabetogenesis can be achieved.
Comparison of the effectiveness of solid nutrient medium in the in vitro cultivation of Neisseria gonorrhoeae isolates
Authors: Nosov N. Yu. , Shagabieva Yu. Z. , Shpilevaya M. V. , Solomka V. S.
Published: July 2023

Background. Neisseria gonorrhoeae is a facultatively anaerobic microorganism which is extremely demanding to the composition of a nutrient media and cultivation conditions. In a situation of the increasing shortage and cost of foreign components for the preparation of solid nutrient media, it is important to study the possibility of growing hard-to-cultivate microorganisms on domestically produced nutrient media.The aim of the study. To evaluate the growth of gonococcus colonies on two types of solid nutrient media – chocolate agar with growth and selective additives prepared using imported reagents and chocolate agar with growth additives manufactured by “Gem LTD” (Moscow, Russian Federation).Materials and methods. А reference strain of N. gonorrhoeae NCTC 12700/ ATCC 49226 and two types of chocolate agar (the first one – prepared in the State Scientific Center of Dermatovenerology and Cosmetology using imported components and the other one – from the domestic manufacturer “Gem LTD”) were used in the research.Results. The equivalence of the growth properties of both studied types of nutrient media when cultivating pure gonococcus was revealed.Conclusions. Ready-to-use chocolate agar with growth additives produced by “Gem LTD” can be successfully used in the laboratory for the cultivation of N. gonorrhoeae pure culture. Primary isolation of N. gonorrhoeae strains from clinical material is more appropriate to carry out on a medium that suppresses the growth of foreign microflora due to the inclusion of antibiotic additive. The organization of production of domestic bacteriological media for microorganisms with high nutrient requirements reduces the dependence of domestic microbiology on import and ensures their rapid delivery to laboratories.
Penilaian Tingkat Risiko Postur Kerja Menggunakan Metode REBA dan Biomekanika Pada Aktivitas Mengangkat Beban
Authors: Jordan Aldi Rizki , Wardani Pratiwi Sri , Subagiada Kadek , Putri Devina Rayzy Perwitasari Sutaji , Natalisanto Adrianus Inu
Published: July 2023

The activity of lifting weights has many risks that can lead to complaints and work accidents such as mistakes in lifting excessive loads, overly bent postures, and other complaints that result in uncomfortable working conditions. This research was conducted to determine the risk level of work posture using the REBA method and biomechanics in lifting weights with different lifting variables. The research were took documentation data, angle and distance measurements by using the Kinovea application, and the data analyzed by using the REBA Assessment Worksheet and biomechanical equations. Based on the results obtained, the activity of lifting burdens on workers from the aspect of the REBA method mostly has a high level of risk category and only 1 worker has a moderate level of risk category. Meanwhile, from the biomechanics aspect, most of them have a risk level in the careful category, 1 worker has a risk level in the safe category, and 1 worker who has lifted a load of 50 kg has a risk level in the dangerous category.
Razlike u zadovoljstvu školom i uključenosti roditelja učenika tipičnog razvoja i s teškoćama u razvoju u aktivnosti u domu i školi
Authors: Kovač Vlatka , Opić Siniša , Hrvatić Neven
Published: July 2023

Cilj rada bio je utvrditi razlike u zadovoljstvu i uključenosti u školske aktivnosti roditelja učenika osnovne škole tipičnog razvoja i s teškoćama u razvoju. Uzorak u radu čine 896 roditelja učenika drugih i šestih razreda trinaest osnovnih škola sjeverozapadne Hrvatske, od kojih je 57 roditelja učenika s teškoćama u razvoju koji se školuju u redovitome razrednom odjelu u skladu s primjerenim programima odgoja i obrazovanja ovisno o vrsti i stupnju teškoće. Usporedbom ekvivalentnih parova roditelja iz obje skupine utvrđeno je da ne postoji statistička razlika u procjeni zadovoljstva te da je ono za obje skupine iznadprosječno, a za roditelje učenika s teškoćama u razvoju čak i više. Opća uključenost roditelja u školi je gotovo ista za promatrane skupine roditelja, dok roditelji učenika s teškoćama statistički značajno više pomažu svojoj djeci kod kuće, češće potiču čitanje, učenje matematike i prirodoslovnih predmeta te su općenito više uključeni u učenju kod kuće. Rezultati analize pokazuju da zadovoljstvo školom roditelja učenika s teškoćama u razvoju pridonosi općoj roditeljskoj uključenosti kod kuće i učenju matematike sa svojom djecom. Provedeno istraživanje ukazuje na potrebu daljnje analize zadovoljstva roditelja i utjecaja na njihovu uključenost u aktivnosti u domu i školi.
Ecological Momentary Assessment with Bereaved Adults: Feasibility, Acceptability, and Measurement Reactivity and their Relationship to Prolonged Grief Symptom Severity
Authors: Mintz Emily , Toner Emma Rose , Skolnik Alexa , Pan Alicia , Frumkin Madelyn , Baker Amanda , Simon Naomi , Robinaugh Donald
Published: July 2023

Most research on prolonged grief has utilized retrospective self-report or interview-based measures. Although valuable, these methods have limitations: they are subject to recall error and bias and provide little information about the dynamics of prolonged grief symptoms as they unfold in daily life. Ecological momentary assessment (EMA) has the potential to overcome these limitations by assessing grief- related symptoms repeatedly over the course of people’s day-to-day lives in their natural environment. However, there remains considerable uncertainty about how bereaved adults will respond to this type of assessment, especially among those with persistent, distressing grief. In the present study, we evaluated the feasibility and acceptability of an EMA protocol, including whether responding to EMA surveys pertaining to grief leads to worsening of grief symptoms (i.e., measurement reactivity) in a sample of bereaved adults with and without high severity of prolonged grief symptoms (indicated by a score of 30 or higher or a score of below 30 on the Inventory of Complicated Grief, respectively; Prigerson et al., 1995). Participants completed a 17-day data collection period in which they responded to six EMA surveys per day on their personal smartphones. Feasibility was determined by the proportion of EMA surveys completed and the portion of participants who withdrew from the study during the EMA period. Acceptability was assessed with a self-report questionnaire administered at the end of EMA data collection. Measurement reactivity was assessed by evaluating the trajectory of prolonged grief symptoms during the EMA period. The mean proportion of assessments completed was 90% (median = 96%). Only 6% of participants withdrew from the EMA portion of the study. Adherence was modestly lower in those with high prolonged grief symptom severity (mean = 86%; median = 96%) than in those without (mean= 93%, median=97%). On average, participants reported agreement that survey frequency and length was acceptable and disagreed with items querying whether the survey was burdensome or time consuming. Those with high prolonged grief severity reported higher average agreement that the EMA questions were personally relevant. No other group differences in acceptability were observed. There was no evidence for systematic worsening of symptoms during EMA data collection. These findings suggest that EMA is feasible, acceptable, and safe for bereaved adults, including those with high prolonged grief severity. Given these findings and the considerable advantages of this method, EMA should be used more widely to advance our understanding of prolonged grief.
Can Generative AI Infer Thinking Style from Language? Evaluating the Utility of AI as a Psychological Text Analysis Tool
Authors: Markowitz David Matthew
Published: July 2023

Generative AI are not currently the choice technology for text analysis, but prior work suggests they may have some utility to assess dynamics like emotion. The current work builds on this empirical foundation to consider how analytic thinking scores from a large language model chatbot, ChatGPT, are linked to analytic thinking scores from dictionary-based approaches like Linguistic Inquiry and Word Count (LIWC). Using over 16,000 texts from four samples and tested against three prompts and two models (GPT-3.5, GPT-4), the evidence suggests there were small associations between ChatGPT and LIWC analytic thinking scores (meta-analytic effect sizes: .058 < rs < .304; ps < .001). Critically, when given the formula to calculate the LIWC analytic thinking index, ChatGPT performed incorrect mathematical operations in 22.1% of the cases, suggesting basic word and number processing may be unreliable with large language models. Researchers should be cautious when using AI for text analysis.
Titanium Microtexture 101, Part I
Authors: Harr Michelle , Pilchak Adam , Semiatin Lee
Published: July 2023

Despite decades of research, fundamental questions still exist regarding the role of microtexture on the deformation, fatigue, and fracture behavior of titanium alloys. This article describes the microstructural evolution processes that result in microtexture formation, while Part II of this series will further elaborate on the effects of microtexture on deformation behavior.
Kinetics of Thermal Pyrolysis of High-Density Polyethylene
Authors: Abbas Ammar S. , Saber Marwa G.
Published: July 2023

Thermal pyrolysis kinetics of virgin high-density polyethylene (HDPE) was investigated. Thermal pyrolysis of HDPE was performed using a thermogravimetric analyzer in nitrogen atmosphere under non-isothermal conditions at different heating rates 4, 7, 10 °C/min. First-order decomposition reaction was assumed, and for the kinetic analysis Kissinger-Akahira-Sunose(KAS), Flynn-Wall-Ozawa(FWO) and Coats and Redfern(CR) method were used. The obtained values of  average activation energy by the KAS and FWO methods were equal to137.43 and 141.52 kJ/mol respectively, these values were considered in good agreement, where the  average activation energy value obtained by CR equation methods was slightly different which equal to 153.16 kJ/mol.
Membangun Kerjasama Tim di Lembaga Pendidikan pada Era Revolusi 4.0
Authors: Firdausi Lutfi , Sulistyorini Sulistyorini
Published: July 2023

In the process of interaction between a subsystem and another subsystem there is no guarantee that there will always be a conformity or match between the executing individuals. At any moment tensions may arise, both between individuals and between groups within the organization. Many factors are behind the emergence of incompatibility or tension, including different personal traits, differences in interests, poor communication, differences in values, and so on. In order for the organization to perform effectively, the interdependent individuals and groups must create a mutually supportive working relationship, towards the achievement of the organization's goals. The main challenge related to the aspect of educational institutions is to create a conducive culture and create an atmosphere that supports teamwork. The high-performance team consists of people who are truly experts in their fields, this team consists of members who have complementary skills and abilities. The foundation of a successful work team by prioritizing human relationships, effective teams are respecting each other, building discipline and building commitment so that the team can work effectively. Keywords: Leadership, Effective Team
A Multimodal Discourse Analysis of Visual Illustrations Related to COVID-19 Awareness in Nigeria
Authors: AMODU Abideen David , OTESILE Ayodeji Ebunoluwa
Published: July 2023

The current paper aims to discuss the impact of visual illustrations related to the COVID-19 pandemic in Nigeria. To embark, this study utilizes visual resources, precisely images to facilitate a massive audience by incorporating various modes of visual communication, such as graphics, typography, and attractive layouts to engage the public.  This study deploys  a multimodal discourse analysis of selected COVID-19 pandemic visual illustrations. The current study examines ten (10) COVID-19 visual illustrations. These /visual illustrations were collected from the official website of the Nigeria Centre for Disease Control (NCDC). This research identified that in creating awareness concerning the spread of the COVID-19 pandemic and its mitigation, there is a dire need to enhance  modes of communication using multiple modes of awareness, such as images such as graphics, typography, and other semiotic resources. To elaborate further a large range of visual resources were utilized to analyse the linguistic efficiency of selected visual resources to communicate with the larger audience with concise language and expression. When multiple modes are used effectively in the images, they become audience-affective, such that the attention of the reader or target audience is drawn to the content of the image. Moreover, this study recommended that to achieve the maximum effect of awareness concerning the COVID-19 pandemic, multiple modes model should be used by communicators to facilitate the larger audience Furthermore, it should be used in such a way that they are harmonised and interrelate, contributing to the realisation of meaning throughout the text.
Role of Misconceptions and Miscommunications in Theatrical Characters: Analyzing Speech Acts in the Namibian Plays
Authors: Simasiku Virginia , Woldemariam Haileleul Zeleke
Published: July 2023

The current study examines the misconceptions and misunderstandings in the speech acts  of the characters within three Namibian plays, namely  The Oracle of Cidino written by Francis Nyathi, Checkmate by Maria Amakali, and The Bride and Broom penned by David Stone Ndjavera. Furthermore, this research examines the ways, which depict instances where characters’ speech acts lead to misconceptions and misunderstandings in the selected plays. Thereby, delving into these aspects, this study sheds light on the complexities of communication within the selected theatrical works. Moreover, this study examines the impact of miscommunication in discussions, which can culminate differences in understanding of speech acts between the speaker and the listener. The listener, however, is prone to a variety of emotional reactions, which arise from misunderstandings in a conversation - including feelings of joy, humor, embarrassment, regret or self-assumption, and impression of the speaker's utterance. The results of the enquiry evinced that the location-based actions performed by the characters in the three selected plays included declarative, interrogative, and imperative resources that are extracted from three Namibian plays. This is achieved by adopting a discourse analysis research approach, identifying, and explaining speech acts based on five classes of speech acts.  Additionally, the current study is established on five functions of speech acts and on the other hand, the declarative statements proliferate the fewest of times since they require specified circumstances to be performed.
Reflections on Digital Transformation in Chinese Regional Financial Holding Companies
Authors: Song Yang
Published: July 2023

This article explores the necessity of digital transformation in Chinese regional financial holding companies, based on the background of their digitalization efforts. It discusses the requirements set by policies, the demand for sustainable development in company operations, and the impact of the pandemic on driving digitalization. By analyzing specific challenges faced in the digital transformation of regional financial holding companies, clear pathways for progress are proposed.
Multicultural Islamic Religious Education Based on Local Wisdom: The Analysis of "SILAS" Values in Sundanese Culture
Authors: Anggraeni Dewi , Hadiyanto Andy , Hakam Ahmad
Published: July 2023

Extreme religious understanding is one of the potentials that can hinder a harmonious religious life. Islamic religious education at universities has a significant role in shaping moderate attitudes. Multicultural Islamic Religious Education based on local wisdom aims to integrate the concept of multiculturalism by adopting local wisdom SILAS. This qualitative analytical research was conducted by analyzing the values silih asah, silih asih, and silih asuh (SILAS) as one of the local wisdom of the Sundanese culture. From data collection through observation, interviews, and documentation studies then analyzed, it is known that SILAS, as a Sundanese cultural philosophy contains harmonious values in building human qualities that can be integrated into Islamic Religious Education learning. The results of this study show that the essence of SILAS is universal to human values in line with religious values. The multicultural approach based on local wisdom in Sundanese culture SILAS is inseparable from educational aspects, such as ontological relationship with God, epistemology, openness to knowledge, and axiology to uphold human values. Islamic Religious Education learning with local culture provides competence to students to analyze and provide ideas or solutions to various cultural and religious conflicts.
Laryngeal Complications of Prolonged Cricothyroidotomy by Misplaced Percutaneous Dilatational Tracheostomy
Authors: Lee Sang Jae , Song Si-Youn , Na Hyung Gyun , Choi Yoon Seok
Published: July 2023

Despite several advantages, percutaneous dilatational tracheostomy (PDT) performed by physicians who are unfamiliar with head and neck anatomy can result in malpractice and cause significant complications although laryngeal complications due to prolonged cricothyroidotomy caused by malpractice PDT have not been reported. Here we report a 64-year-old female who complained of dysphonia while receiving a fenestrated tube. The tube was mispositioned tube caused by malpractice PDT; the tube was placed at the cricothyroid membrane for four months without awareness. To correct subglottic stenosis and vocal cord edema, the patient underwent tracheostomy conversion and suspension laryngomicrosurgery. Although her voice slightly improved after the operation, she was unable to decannulate the tube and developed laryngeal web and subglottic stenosis. To reduce complications, PDT must be performed with accurate knowledge of anatomy
The Fatal Interplay between Stress Induced Cardiomyopathy, Arrhythmia and Cardiogenic Shock
Authors: Khabsa Mariam , Al Kalaji Bilal , Rasheed Sumaya , Zahra Farah , Patel Alok
Published: July 2023

A 59-year-old man presents to the hospital following a syncopal episode after a low-speed car accident without visible injuries. He was diagnosed with stress cardiomyopathy and severe triple-vessel coronary artery disease. The case was complicated by complete heart block that culminated in refractory cardiogenic shock. Literature and current approach are reviewed.
A novel therapeutic vaccine targeting the soluble TNFα receptor II to limit the progression of cardiovascular disease: AtheroVax™
Authors: Iversen Patrick L. , Kipshidze Nicholas , Kipshidze Nodar , Dangas George , Ramacciotti Eduardo , Kakabadze Zurab , Fareed Jawed
Published: July 2023

The burden of atherosclerotic cardiovascular disease contributes to a large proportion of morbidity and mortality, globally. Vaccination against atherosclerosis has been proposed for over 20 years targeting different mediators of atherothrombosis; however, these have not been adequately evaluated in human clinical trials to assess safety and efficacy. Inflammation is a driver of atherosclerosis, but inflammatory mediators are essential components of the immune response. Only pathogenic forms of sTNFR2 are acted upon while preserving the membrane-bound (wild-type) TNFR2 contributions to a non-pathogenic immune response. We hypothesize that the inhibition of sTNRF2 will be more specific and offer long-term treatment options. Here we describe pre-clinical findings of an sTNFR2-targeting peptide vaccine (AtheroVax™) in a mouse model. The multiple pathways to synthesis of the soluble TNFRII receptor (sTNFRII) were identified as sTNFRII(PC), sTNFRII(Δ7), and sTNFRII(Δ7,9). The sTNFRII(Δ7) peptide, NH2-DFALPVEKPLCLQR-COOH is specific to sTNFR2 based on an mRNA splice-variant in which exon 6 is joined to exon 8. The role of sTNFRII(Δ7) as a mediator of prolonged TNFα activity by preventing degradation and clearance was investigated. Inflammation is a critical driver of onset, progression and expansion of atherosclerosis. The TNFα ligand represents a driver of inflammation that is mediated by a splice variant of TNFR2, referred to as sTNFRII(Δ7). The multiple forms of TNFRII, both membrane bound and soluble, are associated with distinctly different phenotypes. sTNFRII(PC) and sTNFRII(Δ7) are not equivalent to etanercept because they lack a clearance mechanism. The unique peptide associated with sTNFRII(Δ7) contains a linear B-cell epitope with amino acids from both exon 6 and exon 8 supporting the vaccine design. Animal studies to evaluate the vaccine are ongoing, and results will be forthcoming. We describe a peptide vaccine targeting sTNFR2 in limiting the progression of atherosclerosis. A therapeutic vaccine limiting the progression of atherosclerosis will greatly contribute to the reduction in morbidity and mortality from cardiovascular disease. It is likely the vaccine will be used in combination with the current standards of care and lifestyle modifications.