bluuebunny/crossref_metadata_2025 huggingface dataset:
The clinical challenges of homologous recombination proficiency in ovarian cancer: from intrinsic resistance to new treatment opportunities
Authors: Zielli Teresa , Labidi-Galy Intidhar , Del Grande Maria , Sessa Cristiana , Colombo Ilaria
Published: July 2023

Ovarian cancer is the most lethal gynecologic cancer. Optimal cytoreductive surgery followed by platinum-based chemotherapy with or without bevacizumab is the conventional therapeutic strategy. Since 2016, the pharmacological treatment of epithelial ovarian cancer has significantly changed following the introduction of the poly (ADP-ribose) polymerase inhibitors (PARPi). BRCA1/2 mutations and homologous recombination deficiency (HRD) have been established as predictive biomarkers of the benefit from platinum-based chemotherapy and PARPi. While in the absence of HRD (the so-called homologous recombination proficiency, HRp), patients derive minimal benefit from PARPi, the use of the antiangiogenic agent bevacizumab in first line did not result in different efficacy according to the presence of homologous recombination repair (HRR) genes mutations. No clinical trials have currently compared PARPi and bevacizumab as maintenance therapy in the HRp population. Different strategies are under investigation to overcome primary and acquired resistance to PARPi and to increase the sensitivity of HRp tumors to these agents. These tumors are characterized by frequent amplifications of Cyclin E and MYC, resulting in high replication stress. Different agents targeting DNA replication stress, such as ATR, WEE1 and CHK1 inhibitors, are currently being explored in preclinical models and clinical trials and have shown promising preliminary signs of activity. In this review, we will summarize the available evidence on the activity of PARPi in HRp tumors and the ongoing research to develop new treatment options in this hard-to-treat population.
Mechanistic Study and Application of Anionic/Cationic Combination Collector ST-8 for the Flotation of Spodumene
Authors: Zhao Jun , Luo Huihua , Liu Yutong , Liu Ju , Peng Liqing , Cen Mei , Li Fengyuan
Published: July 2023

The mechanism of anionic/cationic combination collector ST-8 for the efficient separation of spodumene and feldspar was investigated by flotation tests, surface tension measurements, zeta potential measurements and infrared spectroscopy analysis. The flotation results indicated that when the optimum molar combination of sodium oleate and dodecylamine was 6:1-10:1 and pH=8.5 or so, the recovery of spodumene reached a maximum of 80% and that of feldspar reached about 24.5%. Zeta potential measurements showed that the negative shift of the kinetic potential on the surface of spodumene was much stronger than that on the surface of feldspar, indicating that the adsorption capacity of the combined collector on spodumene surface and feldspar surface was greatly different. From the surface tension as well as the synergistic parameters, there was a strong mutual attraction between dodecylamine and sodium oleate, and there was a significant synergistic effect between them. Infrared spectroscopy indicated that the combined collector chemisorbed on the mineral surface, and the intensity of the absorption peak after the action of spodumene was much stronger than that after the action of feldspar. The solution chemistry of the combined collector revealed that at pH 8.5, the positively charged ions RNH3+ and (RNH3+)22+ in dodecylamine and the negatively charged RCOO- and (RCOO-)22- ions in oleic acid form highly reactive complexes to interact with the mineral surface by electrostatic gravitation, thus achieving efficient separation of spodumene and feldspar. Finally, from the closed circuit test results, a flotation index of 6.34% Li2O grade and 88.51% Li2O recovery was obtained.
Magnetic Field Sensor Based on Directional Coupling in a Magnetic Fluid-Filled Photonic Crystal Fiber
Authors: Liu Yingchao , Zhang Lijun , Ren Shuang , Zhang Rundong , Cao Peigang , Chen Hailiang
Published: July 2023

In this paper, a sensitivity sensor of dual-core photonic crystal fiber (DC-PCF) filled with magnetic liquid is introduced and investigated by the finite element method (FEM). To regulate the energy coupling involving the two cores, the magnetic fluid is filled into the pore between the two cores. To adjust the coupling between the supermodes in the DC-PCF, the refractive index of the magnetic fluid-filled air hole may change due to the external magnetic field. This specifically created a magnetic fluid-filled DC-PCF, the magnetic fluid-filled hole is not used as the core for energy transmission, thus avoiding transmission loss. The dip wavelength and the magnetic field displayed an excellent linear connection between 80 and 260 Oe, depending on the numerical data. The detection sensitivity of the magnetic field reached 515.75 pm/Oe at a short fiber length of 482 m. The designed magnetic fluid-filled DC-PCF has high sensitivity and small volume and has great application prospects in medical and industrial field magnetic field detection.
Navigating the Virtual Frontier: The Convergence of Decentralized Finance and the Metaverse
Authors: La Barbera Salvatore
Published: July 2023

This study delves into the integration of Decentralized Finance (DeFi) within metaverses, probing its implications and potential. It elucidates DeFi protocols and the intricacies of metaverses before inspecting their intersection and the resulting economic prospects. The analysis further appraises inherent risks such as financial volatility, security, and regulatory issues. Case studies provide tangible insights into DeFi applications in metaverses. Future trajectories of DeFi in metaverses are projected, underlining the possible impact on the broader financial sector. This paper contributes to burgeoning research at the nexus of blockchain technology, finance, and virtual reality.
Selection and Characterization of Phosphate Solubilizing Fungi and Their Effects on Coffee Plantations
Authors: Arias Rosa María , Heredia Gabriela Patricia , Perea Yamel del Carmen , De la Cruz Yadeneyro , García Karla Yosselin
Published: July 2023

The use of phosphate-solubilizing fungi in coffee cultivation is an alternative with which to reduce the use of fertilizers. The objective of this study was to analyze the mechanisms involved in the phosphorus solubilization of the fungal strains and to evaluate the effect of a phosphate-solubilizing strain on the coffee plants. For this, phosphorus-solubilizing fungal strains were selected for evaluation of their solubilization potential and phosphatase activity. Coffee plants were inoculated in the field with a phosphate solubilizing strain, and soil and foliar soluble phosphorus, as well as coffee bean yield, were quantified. Of the 151 strains analyzed, Aspergillus niger, Penicillium waksmanii, and Penicillium brevicompactum showed the highest solubilization. Aspergillus niger and P. waksmanii presented the highest soluble phosphorus values; however, P. brevicompactum showed the highest phosphatase activity. The P. brevicompactum strain inoculated on the coffee plants did not favor foliar phosphorus content but increased the soil soluble phosphorus content in two of the coffee plantations. The plants inoculated with the phosphate solubilizing strain showed an increase in coffee bean weight on all plantations, although this increase was only significant in two of the three selected coffee plantations.
Characteristics of Radon and Thoron Indoor and in Soil Gas and Sources of High Radon Potential in Urumqi, Xinjiang, Northwest China
Authors: Wang Nanping , Yang Jingming , Wang Haochen , Jia Binlin , Peng Aimin
Published: July 2023

Urumqi City, located in the northwest of China, is a city with high indoor radon concentration in nationwide indoor radon survey in China. This study focuses on the assessment of indoor radon level and its potential sources in this city. Indoor radon measure using RAD7 and solid nuclear track detector (SSNTD), soil gas radon by RAD7 and determining specific activity of uranium and radium in soil samples by a high pure germanium spectrometer were performed from 2021 to 2023. The results reveal a wide range of indoor radon concentrations in Urumqi, with anomalies above 400 Bq/m3 in some dwellings. The arithmetical and geometric mean values of indoor radon concentration in Urumqi are 90.24 ± 83.04 Bq/m3 and 66.25 Bq/m3, respectively. The geometric mean values of radon and thoron by SSNTD is 110 Bq/m3 and 109 Bq/m3. The analysis suggest that the activity of faults and fault structures are the main factors influencing indoor radon levels, with frequent earthquakes contributing to higher average radon concentrations. Additionally, investigations into indoor radon and building material radioactivity in detailed are recommended for buildings with radon anomalies and the source of indoor radon anomalies.
New Evidence-Based Diagnostic Criteria for Neurosarcoidosis
Authors: Chamoun Viquar , Thompson Edward , Giovannoni Gavin
Published: July 2023

Background: Neurosarcoidosis is a great mimic, and its distinction from multiple sclerosis and other disorders can be particularly troublesome. We investigated whether cerebrospinal fluid (CSF) examination could help distinguish these two conditions and propose new diagnostic criteria. Methods: Stringent hierarchical diagnostic criteria were formulated. These were then applied prospectively to 531 neurological patients in whom neurosarcoidosis entered the differential diagnosis. The CSF total protein (TP), white cell count (WCC) and angiotensin-converting enzyme (ACE) levels were measured. The CSF and serum IgG patterns after isoelectric focusing were compared. Not all CSF parameters were measured in every patient. Results: 85/531 (16%) cases examined were diagnosed with neurosarcoidosis. Only 22 of these 85 (26%) met stringent diagnostic criteria. Intrathecal synthesis of oligoclonal IgG was evident in only 1/19 (5%) who fulfilled these criteria compared to 19/59 (32%) cases who did not (p = 0.03). CSF TP levels > 1g/L were more common in patients meeting the stringent criteria compared to the remainder of the patients, i.e. 11/22 (50%) vs 14/58 (24%) (p<0.05). Eleven out of 20 cases (55%) fulfilling stringent criteria had elevated CSF WCCs, and 6/12 cases (50%) had raised CSF ACE, neither significantly different from the remaining cases. Mean CSF TP, WCC, and ACE levels did not differ significantly between any groups of patients. Interpretation: Large elevations in CSF total protein, white cell count, and ACE occur in neurosarcoidosis but are rare in multiple sclerosis. However, the diagnostic use of these tests is limited since minimal changes may occur in both conditions. In contrast, intrathecal synthesis of oligoclonal IgG is a powerful discriminator because it is very uncommon in neurosarcoidosis whilst occurring in 95-98% of cases of multiple sclerosis. This observation implies that the immunopathogenesis of the two disorders is quite different. We suggest caution in diagnosing neurosarcoidosis when intrathecal oligoclonal IgG synthesis is detected. We propose new diagnostic criteria for neurosarcoidosis for future research.
Strategies to Reduce Maternal Death Rate and Improve the Provision of Quality Healthcare Services in Selected Hospitals of Vhembe District Limpopo Province: A Qualitative Study Report
Authors: Mahada Tshisikhawe , Tshitangano Takalani Grace , Mudau Azwinndini Gladys
Published: July 2023

The maternal death rate remains high in South Africa despite the availability of many existing strategies to improve the quality of service. A 30% increase in maternal mortality rate was reported between 2020-2021, with Limpopo ranking fourth highest out of nine provinces. Vhembe district remained number three with a high maternal death rate. This study explored strategies to reduce the maternal death rate and improve the provision of quality maternal healthcare services in selected hospitals of Vhembe district, Limpopo province. One hospital was purposively sampled from every four municipalities. A qualitative approach using phenomenological design was employed. Twenty-eight participants were sampled using a convenience sampling method. The semi-structured interview guide was used to collect data. An audio recorder was also used until data saturation. Data saturation was reached at the 20th participant, but the researcher continued until 28 sampled participants were interviewed. Interpretative phenomenological analysis was used following the analytical stages of interpretative data analysis. The study proposal was ethically cleared by the University of Venda Ethics Committee (FHS/22/PH/08/3108). Results indicate that despite implementing strategies to improve maternal healthcare services and reduce the maternal death rate, several factors, such as lack of material resources, shortage of staff, incompetent staff, and poor infection control, affect the quality of maternal health service in Vhembe district. Limpopo Department of Health and hospital management should ensure that hospitals have all necessary resources and support healthcare professionals through in-service training to ensure the functionality of existing strategies.
Calcination of Various Eggshell Wastes into CaO Heterogeneous Catalysts
Authors: Dewi Dona Kurniawati , Putri Vira Mawardha , Febriyanti Vita , Yudha Cornelius Satria
Published: July 2023

ABSTRACT. The high food industry waste can cause pollution including a pungent odor and the emergence of bacteria that cause disease. Egg shells are confectionery waste that is commonly found in household waste and the food industry. The accumulation of eggshell waste can cause various diseases such as abdominal pain, diarrhea, fever, and cramps in the stomach caused by Salmonella bacteria. Thus, further processing of egg shells is required. In this study, eggshell waste was processed into heterogeneous catalysts of CaO. This heterogeneous CaO catalyst has the potential to be used as a catalyst in the manufacture of biodiesel. In this process, egg shells are processed by the calcination method. The variables used are shell type and calcination temperature. The shell variables used were chicken egg shells, duck egg shells, and quail egg shells. While the temperature variables used are at temperatures of 600 ºC and 800 ºC. To determine the quality of heterogeneous CaO catalyst, characteristic tests were varied out in the form of SEM-EDX and FTIR. From the analysis, the most effective results were in the form of chicken eggshell variables at a calcination temperature of 800 ºC.

Keywords: Calcination, CaO, Catalyst, Shell, Waste
Regeneration of Spent Nickel Catalyst via Hydrometallurgical Method
Authors: Amelia Fransisca Poppy , Sari Erica Puspita , Norman Hafiz , Salsabil Muhammad Alhadilansa , Yudha Cornelius Satria
Published: July 2023

Abstract. Nickel Catalyst is one of the common catalysts found in chemical industries. However, this catalyst has a limited lifetime indicated by having performance or activity drop so it is potentially become dangerous waste if the handling is not proper. The spent nickel catalyst needs to be processed to recover and avoid pollution towards the environment. The Hydrometallurgy method is a proper method to process nickel catalyst waste. The purpose of this research is to investigate the characteristic of a regenerated nickel catalyst when it is treated with HCl and H2SO4 as the lixiviant. In this research, the spent nickel catalyst was treated with HCl and H2SO4 in the presence of 2% H2O2 reductant under room conditions and mixing rate at 200 rpm for 30 minutes of reaction. The leaching filtrate was precipitated using NaOH solution while the formed precipitate was heated at 800 °C for 3 hours. The regenerated catalyst was characterized using FTIR and SEM-EDX. The SEM images showed regenerated catalyst prepared using the HCl solution has a different morphology compared to the one using the H2SO4 solution. Based on FTIR analysis, both samples exhibit Ni-O and C-O groups. Based on elemental analysis, the highest nickel concentration was obtained by using HCl with a Ni content of 25.98%w/w, compare to sulfuric acid (H2SO4) with a Ni content of 10.94%w/w. The Ni content can be improved by the addition of a washing step after the sintering process.

Keywords:

Hydrometallurgy Nickel Catalyst, Waste, Leaching, Sintering
Concomitant Unstable and Stable Gravity Stress Tests on Weight-Bearing Stable Weber B Ankle Fractures Treated Nonoperatively
Authors: Gregersen Martin G. , Robinson Hilde Stendal , Molund Marius
Published: July 2023

Background:

Replacing gravity stress tests with weight-bearing radiographs to evaluate the stability of Weber B (also called Lauge-Hansen supination-external rotation [SER]) ankle fractures results in a lower surgery rate, thus avoiding associated risks and complications. Still, nonoperative treatment of weight-bearing stable fractures is controversial because of the scarcity of strong evidence. We investigated the influence of a concomitant unstable gravity stress test compared with a stable gravity stress test on outcomes after nonoperative treatment of weight-bearing stable fractures.

Methods:

We performed a prospective, noninferiority study on 149 patients with Weber B ankle fractures and stable weight-bearing radiographs. Gravity stress radiographs classified fractures as stable (SER2 [n = 88]) or partially unstable (SER4a [n = 61]). All were treated with a functional orthosis and weight-bearing was allowed; patients were followed for 2 years. The primary outcome was the Manchester-Oxford Foot and Ankle Questionnaire (MOXFQ), with a range from 0 to 100, in which lower scores indicate fewer symptoms. A noninferiority margin was prospectively defined as 7.5 points. The secondary outcomes included the Olerud-Molander Ankle Score, assessment of ankle congruence, and treatment-related adverse events.

Results:

The primary outcome data were available for 144 (96.6%) of 149 participants at 2 years. The between-group difference in the MOXFQ score was 1.0 point (95% confidence interval, −1.4 to 3.4 points; p = 0.397) in favor of the SER2 group, consistent with noninferiority. We found no appreciable between-group differences for any other outcome.

Conclusions:

In Weber B/SER ankle fractures that are stable on weight-bearing radiographs, are treated with removable orthoses, and are allowed to bear weight, a concomitant unstable gravity stress test (SER4a) was not associated with worse patient-reported or radiographic outcomes compared with a stable gravity stress test (SER2) at the 2-year follow-up. Thus, the identification of stress instability seems redundant, which questions the applicability of stress instability for surgical decision-making.

Level of Evidence:

Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Orthopaedic Manifestations of Thanatophoric Dwarfism
Authors: DeGenova Daniel T. , Wing Anthony O. , Perugini Anthony J. , Petersen Matthew J. , Misbrener Emily , Tulchin-Francis Kirsten , Kadado Allen
Published: July 2023

Case:

We report the rare case of a 3-year-old male patient with thanatophoric dwarfism, a fatal skeletal dysplasia that arises from an autosomal dominant mutation in the fibroblast growth factor receptor 3 gene. The role of the orthopaedic surgeon in the in the management of this disease is discussed.

Conclusion:

We advocate for the close monitoring of disease progression by the orthopaedic surgery team and offer a potential surgical intervention that may help prevent cardiorespiratory demise.
Digital Marketing Application to Increases Livestock Sales in Sacrificial Cages in Ganggang Panjang Sidoarjo Village Based on Android
Authors: Refinda Achmad Ainun Gusti , Fitrani Arif Senja
Published: July 2023

The need for qurban animals both for the needs of the Eid al-Adha holiday and needs other than Eid al- Adha such as aqiqah, or other important events are very much needed where in the selection of sacrificial animals such as goats or cows are both very important. types of sacrificial goats and cows, the condition of the sacrificial animals so that the results given are very good. In the process of selecting, purchasing, distributing sacrificial animals, they still use the manual method, which is less efficient, so there is a need for an application system that can assist in selecting, purchasing, and distributing sacrificial animals. In running the business, most of the service processes that are applied are still manual by checking the condition of the animal by coming to the place so that it is difficult for the customer to come twice or contact by phone. Then, in managing transaction data and issuing notes, it is also still manual. "DIGITAL MARKETING APPLICATION TO INCREASING LIVESTOCK SALES IN QURBAN STAGES IN GANGGANG PANJANG VILLAGE, SIDOARJO BASED ON ANDROID" was created to simplify the process of buying and selling livestock services so as to facilitate work and improve service in these small and medium enterprises. From the results of this study it can be concluded that this system can increase effectiveness because it is not done manually, the features in the information system are easy to use and the transaction data management runs well.
Desde el cuerpo:
Authors: Faúndez Carreño Tania , Ferreira da Silva Silva Fabio
Published: July 2023

Las instituciones de educación superior, en especial las formadoras de profesores/as, se han centrado en la innovación educativa por el impacto que esta tiene en el sistema educacional de cada país. En el contexto de una investigación sobre la innovación educativa y los usos y representaciones del cuerpo con técnicas corporales vinculadas al ritmo afrobrasileño (maculelê), el objetivo de este trabajo es presentar algunas contribuciones de la práctica de expresiones afrobrasileñas implementadas en el curso de Formación Integral «Expresión corporal con el ritmo» / «Laboratorio cuerpo performático», que tiene como misióndesarrollar las competencias genéricas declaradas por el Modelo Educativo de la Universidad del Bío-Bío.Además, daremos cuenta del proceso de enseñanza y aprendizaje de contenidos conceptuales como coordinación tiempo-espacio, percepción corporal, lenguaje y memoria corporal, y trabajo en equipo, atendiendo al cuerpo pospandémico.
¿«El Perú es una gran marca»? Tensiones en la idea de nación de la Marca Perú y la masacre de Bagua (2006-2012)
Authors: Vega Slee Johnatan
Published: July 2023

Se analiza las tensiones en la idea de nación que construye la Marca Perú frente al discurso y acción estatales en torno a la extracción de recursos naturales y los pueblos indígenas. Desde un enfoque crítico antropológico e histórico, se estudia una base empírica constituida por la producción visual y discursiva de la Marca Perú (2009-2012) y la política frente a los pueblos indígenas, lo que se concentra en el gobierno de Alan García (2006-2011) y el conflicto más representativo del desprecio hacia ellos: la Masacre de Bagua (2009). La representación de la nación que construye la Marca se resuelve sobre la base de ideas racializadas que resaltan la diversidad de culturas hacia afuera, apostando por insertarse en los flujos y demandas del mercado global. Las tensiones se reflejan en los conflictos socioambientales y el rechazo a los indígenas, que, destacados culturalmente en el extranjero, son desdeñados en el país, atentando contra su vida y cosmovisión a favor de intereses empresariales.
Influencia de las buenas prácticas de ITIL en la mejora del servicio de Mesa de Ayuda en la empresa Dupree Venta Directa en el año 2020
Authors:   , Hidalgo Garay Luis Alberto
Published: July 2023

Se realizó una investigación sobre la influencia de ITIL en el proceso de mesa de ayuda de una empresa comercializadora de productos por catálogo en el año 2020 con el fin de encontrar una optimización este proceso, para esto se utilizaron los casos que se tienen registrado en la plataforma de gestión de atención (GLPI) tomando como muestra 158 casos registrado en el mes de diciembre, a los cuales se les aplico una lista de verificación para validar la influencia de utilizar ITIL. Los resultados mostraron que el uso de ITIL mejora los tiempos de respuesta, la calidad de atención y un adecuado uso de la plataforma de gestión de mesa de ayuda. Por lo tanto, podemos indicar que usar marcos de referencias de buenas prácticas como ITIL aportan en la mejora de los procesos de atención de la mesa ayuda pero que estas deben se deben ajustar buscando alinearse a los procesos de la empresa.
Premezcla de quinua y cañihua
Authors:   , Avendaño Capcha Fiorella Alicia , Castañeda Flores Valeri Claritsa , Ruiz Carrillo Xiomara Crisell , Zavaleta Galvez Cristhian Bartok
Published: July 2023

El presente plan de negocio tiene como finalidad crear una empresa denominada Allin S.A, la cual brindará una premezcla con harina de quinua y cañihua para la elaboración de panqueques que llevará por nombre Kiñiwa y ofrecerá múltiples beneficios. Actualmente en el Perú abundan alimentos poco saludables y el consumo de alimentos procesados ha aumentado en 265%. Asimismo, gran parte de la población peruana está optando cada vez más por un estilo de vida saludable. Es por ello que se ha propuesto la creación de Allin, una empresa que se compromete con la nutrición y salud de las personas, brindando al consumidor la experiencia de disfrutar de un postre de forma nutritiva y saludable. En el siguiente trabajo se observará el modelo de negocio y la viabilidad, por ello el plan de negocios cuenta un capítulo y nueve subtítulos: Subtítulo I, se hace un análisis del entorno; en el Subtítulo II , se abarca el sondeo de mercado local; en el Subtítulo III, se realiza un análisis de la empresa; en el Subtítulo IV, se hace una presentación de la misión visión, objetivos estratégicos estrategia del negocio, fuentes generadoras de la ventaja competitiva; en el Subtítulo V, se observará el Plan de Marketing el cual brinda información sobre los objetivos y las estrategias que se utilizaran para ingresar al mercado mediante el marketing; en el Subtítulo VI, se detalla el Plan de Operaciones, cuáles son las actividades antes iniciar la producción, así como las del proceso de producción; en el Subtítulo VII, se ubica el Plan de Recursos Humanos, en este subtítulo se indica el proceso de reclutamiento, selección y contratación del personal, estrategias…
Plan de negocio para el desarrollo de una empresa de comercialización de productos medioambientales para el monitoreo ambiental de aire en Lima Metropolitana, 2021
Authors:   , Criollo Collahuazo Cristina Grimenez
Published: July 2023

BIO-EP S.A.C es una empresa peruana del rubro medioambiental ubicada en Chorrillos-Lima, ofreceremos productos medioambientales para las más variadas necesidades en control de calidad de aire, para el Sector Industrial. Tendremos especialistas versados y entrenados en la matriz de aire. Además, contaremos con una amplia gama y variedad de productos en stock de las mejores marcas del mercado, que nos permitirán garantizar la calidad total de los mismos. Este plan empresarial enfatizará el proceso hasta la apertura de BIO-EP S.A.C el proyecto se evaluará de manera rigurosa durante los 3 años de apertura, con el propósito de garantizar la subvención financiera de la empresa para su gran apertura. BIO-EP S.A.C desea percibir la atención rápida de clientes que contribuyan con el cuidado medioambiental. Asimismo, BIO-EP S.A.C espera posicionarse en el mercado medioambiental, gracias a la experiencia que contara cada colaborador. Este proyecto nace como respuesta a la necesidad de Lima y sus provincias, que quieren contar con suministros de calidad y que cuenten con disponibilidad inmediata para que puedan ejecutar su servicio de manera continua. En efecto el financiamiento es positivo obteniendo una VAN de S/20,457.10 y TIR de 52%, con estos resultados vemos que es viable financiera y económicamente el proyecto. Tendremos un respaldo financiero de los accionistas con un aporte del 50%, asimismo un préstamo financiero. El presente plan de negocio será de utilidad como referencia para futuros emprendedores que piensen poner en marcha el plan de negocio, dado que la clave principal es la calidad de servicio y la atención al cliente, estos son elementos fundamentales para el desarrollo de la empresa.
Unsteady Features of Laminar Viscous Incompressible Flow and Temperature Dissemination through a Rotating Bent Rectangular Channel: The Case of Negative Rotation
Authors: Adhikari Sreedham Chandra , Hasan Mohammad Sanjeed , Akter Rabeya , Mondal Rabindra Nath
Published: July 2023

The authors have requested that this preprint be removed from Research Square.
The hot-e lasers based on electron transfer enhanced by electric polarization under photo-electric co-excitation in perovskite and metal
Authors: Pan Yong , Gao Dongwen , Zhao Yuxin , Gao Dangli
Published: July 2023

The hot electron transfer resulting fluorescence enhancement has the significant meaningful for theory and experiment of photoelectric devices studying. However, the laser emission based on hot electron transfer directly is difficult to realize because of the low transfer efficiency. To achieve laser with new generation mechanism base on hot-electron transfer, the photo-electric co-excitation are proposed for improving the efficiency of hot electron transfer. The lasing behavior at 532 nm are realized with a threshold of 5 kw cm-2&1 μA, which can be considered as the hot e transfer lasing. For details, number of hot electrons transfer process were described via transient absorption spectrum according to the improved ground state bleaching and excited state absorption signal in device ON. Through comparing to optical pump only, the quantum efficiencies of hot electron generation (HEG) and hot electron transfer (HET) were increased by this method about 31% and 31% (about 2.2 and 3.5 times), respectively. Efficient hot electron transferring from the charge regulation of metals by adding an electric field was confirmed. Most importantly, a triple gain mode coupling device including local surface plasmon, hot-e transfer and array oscillation was presented in experiment and simulation. This study can provide theoretical and experimental reference for the research of hot electron lasers and device.
A generalized framework for designing open-source natural hazard parametric insurance
Authors: Steinmann Carmen B. , Guillod Benoît P. , Fairless Christopher , Bresch David N.
Published: July 2023

Parametric insurance schemes allow for payouts to be triggered by real-time hydro-/meteorological parameters instead of waiting for damage assessments, which means they can be settled swiftly, giving people access to funds right after the event. In this work we propose a framework to design parametric insurance schemes and systematically quantify the basis risk: the difference between the parameter-based payout and the actual damage. We implement the framework in the open-source global risk assessment platform CLIMADA and illustrate it with two stylized parametric insurance case studies, targeting tropical cyclones in Mozambique and winter storms in France. The data used and the provided code base are globally-consistent, open-source, and readily available. The presented methods are therefore applicable in data-scarce areas and accessible to stakeholders from the public and private sector. Moreover, our approach can easily be adapted to other hazards and exposures worldwide. This improves the accessibility and transparency of such innovative insurance schemes.
Massive Mimo Antenna Array at Terahertz Band for Short-range Communications
Authors: KOUNDAL POONAM , SINGH SIMRANJIT , KAUR RAJBIR
Published: July 2023

The hexagonal-shaped single-patch antenna and its 10×10 massive MIMO (Multiple-Input Multiple-Output) antenna array is designed for wireless network applications. Polyimide, with a dielectric constant of 3.5 and thickness of 0.007 mm, is the material utilized for the substrate. The rectangular microstrip patch antenna used to create the massive MIMO antenna array is incredibly small, measuring 0.0792mm × 0.15mm × 0.007mm in size. For resonating frequency, a number of performance metrics are computed, including reflection coefficient, antenna gain, bandwidth, VSWR, antenna efficiency, ECC, and gain diversity. The proposed massive MIMO antenna array has a return loss of less than − 10 dB and covers a very large bandwidth i.e., 67.5 GHz. For the resonant frequency band, the proposed array has a maximum attainable antenna gain is 20.8 dB, and its antenna efficiency is 86%. The proposed massive MIMO antenna array can work well for a variety of terahertz applications because of its enhanced characteristics.
Non-Bianisotropic Meta Material Split Ring Resonator Loaded With MIMO Antenna For Wireless Body Area Networks
Authors: Mood Yugender , R Pandeeswari
Published: July 2023

In this work, a novel MIMO antenna that improve the antenna parameters by using a nonbianisotropic split ring resonator (NBSRR) metamaterial (MTM) is presented. The proposed antenna is capable of covering the tri-band resonance frequencies of 4.8GHz, 5.6GHz, and 7.1GHz, which is commonly used for medical and industrial applications. The proposed antenna’s measurement is (56 × 32 ×1.6) mm3. By utilizing a metamaterial component named NB-SRR and a split ring structure, the proposed antenna’s resonant frequency is determined. The NB-SRR metamaterial improves the MIMO antenna’s performance by reducing the coupling between the antennas and improving the radiation pattern. We have simulated the antenna with and without NB-SRR, and provided the comparison results.The simulation outcomes indicate that the suggested design is appropriate for WBAN applications and holds great potential to enhance the wireless communication systems efficiency.
SLAMF7 predicts prognosis and correlates with immune infiltration in serous ovarian carcinoma
Authors: Deng Yalong , Zhang Lu , Dai Changyuan , Xu Yan , Gan Qiyu , Cheng Jingxin
Published: July 2023

Background: Signaling lymphocytic activation molecule family members (SLAMFs) play a critical role in immune regulation of malignancies. However, the function of SLAMFs in ovarian cancer (OV) is rarely studied.
Methods: The expression analysis of SLAMFs was conducted based on the TCGA-OV and GEO databases. Immunohistochemistry (IHC) was further performed on tissue arrays (n = 98) to determine the expression of SLAMF7. Kaplan-Meier plotter and multivariate Cox regression model were used to evaluate the correlation of SLAMF7 expression with survival outcomes of patients. The molecular function of SLAMF7 in OV was further investigated using Gene Set Enrichment Analysis (GSEA).
Results: SLAMF7 mRNA expression were significantly upregulated in OV tumor tissue compared to normal tissue. IHC revealed that SLAMF7 expression was located in the interstitial parts of tumor tissue, and higher SLAMF7 expression was associated with favorable survival outcomes. GSEA demonstrated that SLAMF7 is involved immune-related pathways. Further analysis showed that SLAMF7 had a strong correlation with the T cell-specific biomarker (CD3) but not with the B cell (CD19, CD22, and CD23) and NK cell-specific biomarkers (CD85C, CD336, and CD337). Furthermore, IHC analysis confirmed that SLAMF7 was expressed intumor-infiltrating T cells, and the IHC score of SLAMF7 was positively correlated with CD3 (r = 0.846, P＜0.001).
Conclusions: SLAMF7 is expressed in the interstitial components of clinical OV tissue, and higher SLAMF7 expression indicated a favorable prognosis for patients with OV. Additionally, SLAMF7 is involved in T-cell immune infiltration in OV.
Effects of microcystin-LR on purification of drinking water source and physiological response of Hydrocharis dubia (Bl.) backer
Authors: Liu Junfei , Dong Yingbo , Lin Hai
Published: July 2023

The safety of drinking water source directly affects human health. Ensuring the safety of drinking water is critical. Microcystin-LR (MC-LR), a toxic and common pollutant, releases by algae into drinking water source and can impede the in-situ remediation effect of aquatic plant on drinking water source purification. However, the effect mechanism of the MC-LR on the purification of the drinking water by aquatic plant remains unclear. This study aims to explore the effects mechanism of MC-LR (0–10 µg L− 1) on drinking water source purification by Hydrocharis dubia (Bl.) backer. After an exposure experiment, the removal rate of NH4+-N, TP, and COD promoted significantly at low concentrations of MC-LR (< 1µg L− 1). And the removal rate of NH4+-N, TP, and COD increased from 78.9–90.7%, 70.0–93.2%, and 46.0–77.3%, respectively. With the increase of MC-LR concentration, the pollutant removal rate was obviously inhibited causing by concentration-dependent. Furthermore, the growth and development of the Hydrocharis dubia (Bl.) backer roots were significantly promoted at the concentration of 0.2 µg L− 1. The length, tips, surface area, and average diameter of the root increased by 71.3%, 271.4%, 265.5%, and 113.0%, respectively. Chlorophyll contents under low-concentration MC-LR shows a 14.5%-15.7% promoting effect compared with the control group (CK). The activities of POD and CAT were also stimulated with the MC-LR increasing at low concentration. Notably, the MDA contents increased with increasing MC-LR concentration (p < 0.01). Therefore, the presence of MC-LR could affect the purification efficiency of Hydrocharis dubia (Bl.) backer in drinking water source. This study indicates the effect mechanism of MC-LR on drinking source water purification by Hydrocharis dubia (Bl.) backer.
Exploring Vulnerability in Urban Areas: Housing and Living Poverty in Seoul, South Korea
Authors: Lee Yookyung , Han Seungwoo
Published: July 2023

While COVID-19 and climate change have recently had a tremendous impact on the global population, the urban poor have experienced greater suffering. The urban poor in South Korea are not immune to this social phenomenon. The current study explores urban poverty in Seoul, the capital of Korea, by considering the characteristics of housing and living poverty in Seoul. Through a data-driven approach, this study identifies how regions in Seoul form clusters and identifies the magnitude of poverty differences between regions. According to the findings, Seoul can be generally divided into two areas which clearly show the spatial dimension of socio-economic stratification. Furthermore, we find that more than 75% of Seoul is exposed to vulnerabilities. This implies that poverty is a threat to most citizens and that the poor are neighbors in their communities. In this respect, the instability of the poor caused by exposure to various types of risks indicates the instability of the living environment for all citizens.
A structured mentored review program improves the quality of peer review: a pre-post intervention study
Authors: Lyons-Warren Ariel Maia , Aamodt Whitley W , Pieper Kathleen M , Strowd Roy
Published: July 2023

Background: Peer review is essential to the advancement of knowledge. However, training on how to conduct peer review is limited, unorganized, and not well studied. Thus, we sought to determine if a structured mentored peer-review program improves the quality of peer review as measured by quantitative assessment of peer review of a standardized manuscript.
Methods: This pre-post intervention study enrolled 55 mentees across 5 cohorts from 2020 to 2023. Each cohort completed pre-program evaluations, participated in two mentored reviews, and completed post-program evaluations over 6 months. The primary outcome measured was total score on the modified Review Quality Index (RQI). Secondary outcomes included participant-reported comfort with and understanding of the review process as well RQI subscores. Pre- and post-program measures were compared using the Wilcoxon test. The a priori hypothesis was that mentored review would improve peer review quality.
Results: 42 mentees completed both pre- and post-program reviews of a standardized manuscript. For these participants, post-program total modified RQI score (median (IQR) = 31 (26.25-35.75)) was significantly higher than pre-program total scores (26.59 (19.67-29.46)). 53 mentees completed both pre- and post-program surveys which showed improved participant perceptions of the review (median (IQR) scores pre = 4 (3-4) , post =5 (4-5)) and editorial processes (pre = 3 (2-4), post = 4 (4-5)). In addition, confidence in completing an independent review of both scientific (median (IQR) scores pre = 2 (2-3), post = 4 (4-4)) and non-scientific (pre = 3 (2-4) , post = 4 (4-5)) manuscripts significantly increased following program participation. p < 0.0001 for all scores noted above.
Conclusions: A six-month structured mentored-review program including 2 mentored reviews improves peer review quality as measured by the modified RQI as well as participant understanding of publication science.
Fecal Microbiota Profiling in Patients with Irritable Bowel Syndrome and Small Intestinal Bacterial Overgrowth
Authors: Cui Xiufang , Wang Haiyang , Jiang Wenyu , Zhang Hongjie
Published: July 2023

Introduction:
Small intestinal bacterial overgrowth (SIBO) is common in irritable bowel disease (IBS) and has been proposed as an etiologic factor. This study aimed to identify potential fecal microbiota profiles in patients with IBS and SIBO.
Methods
Patients with IBS were divided into two groups: IBS with SIBO (IBS.SIBO+) and IBS without SIBO (IBS.SIBO-). SIBO was identified using a standard glucose hydrogen breath test. A total of 52 subjects were enrolled in this study, of whom 18 were normal controls (NCs), 17 had IBS with SIBO, and 17 had IBS without SIBO. The IBS symptom severity scale, abdominal pain, and health-related quality of life (QoL) were evaluated using questionnaires. Rectal balloon distension was used to measure the visceral sensitivity. Fresh fecal samples were collected, and 16S rRNA gene sequencing analysis was performed to evaluate the structure and diversity of the microbiota among different groups. Correlation analysis was performed to assess the relationship between specific flora and abdominal pain, visceral sensitivity, and QoL.
Results
The richness of the intestinal microbiota in the IBS without SIBO group was significantly lower than that in the IBS with SIBO group (P = 0.012). At the phylum level, the relative abundance of Firmicutes decreased significantly in fecal samples collected from patients with IBS and SIBO compared to those in the NC and IBS groups. No significant difference was found between the IBS with SIBO and IBS without SIBO groups, although the phylum type showed a decreasing trend in the latter. At the genus level, Fusobacterium (P = 0.01) was significantly less abundant in the IBS with SIBO group than in the NC group; however, no significant difference was found between the IBS with SIBO and IBS without SIBO groups. The relative abundance of Firmicutes correlated negatively with the abdominal pain scale (r = 0.436, P = 0.026) and the IBS symptom severity scale (r = 0.494, P = 0.010), whereas a positive correlation was found between the defecation distress threshold and Firmicutes (r = 0.458, P = 0.019).
Conclusions
Fecal microbiota showed obvious dysbiosis in patients with IBS and SIBO compared to those without SIBO. The decreased abundance of Firmicutes may be related to IBS symptoms and abdominal pain, rather than visceral sensitivity.
The Multiscent-20: A Digital Odour Identification Test Developed with Item Response Theory
Authors: Nakanishi Marcio , Brandão Pedro Renato de Paula , Freire Gustavo Subtil Magalhães , Vinha Luis Gustavo do Amaral , Fornazieri Marco Aurélio , Lima Wilma Terezinha Anselmo , Galvão Claudia , Hummel Thomas
Published: July 2023

Although validated and reliable psychophysical tests of olfactory function are available, an easy-to-use and feasible test has yet to be developed. This study aimed to design a digital odour identification test, evaluate its validity, establish a normative curve, and explore the impact of demographic factors. The odour identification test was presented with the Multiscent-20, a hand-held, tablet-like digital scent device that features an integrated odour digital delivery system. The identification performance on the 20 odours was assessed using item response theory (IRT). The normative curve was established by administering the test to a large sample of participants (n = 1,299). The mean identification score was 17.5 (SD = 2.1). The two-parameter logistic IRT model provided the best fit, revealing variation in item discrimination and difficulty parameters. Educational attainment influenced performance, with primary education associated with lower scores. Sex was marginally associated with performance, suggesting that men scored slightly lower than women. This study provides initial evidence supporting the validity of use of the Multiscent-20 as a digital odour identification test. The test's automation and portability enable the standardized delivery of olfactory stimuli and efficient automatic recording and scoring of responses.
The Benefits of Neutral Bicarbonate Ionized Water Baths: An Open-Label, Randomized, Crossover Trial
Authors: Saito Ichiro , Nakayama-Ushikoshi Ryoko , Yamazaki Tomoe , Omagari Daisuke , Matsumoto Naoyuki , Inoue Hiroko , Nukuzuma Chiyoko , Nishino Seiji
Published: July 2023

We performed a randomized, open-label, crossover trial to examine the effects of neutral bicarbonate ionized water (NBIW) bathing on mental stress, sleep, and immune function. Participants who regularly felt stressed were randomly assigned to NBIW or regular bathing for 4 weeks. Mental stress was assessed with the Brief Job Stress Questionnaire (BJSQ) and the Profile of Mood States Second Edition (Japanese version); sleep quality, with the Pittsburgh Sleep Quality Index (PSQI-J; Japanese version) and actigraphy; and immune function, with laboratory tests. PSQI-J scores and actigraphy sleep latency and bed out latency improved significantly more with NBIW bathing than with regular bathing (p < 0.05). Furthermore, NBIW bathing reduced both stress-induced fluctuations in CD4+ and CD8+ T-cell counts and fluctuations in the naïve to memory T cell ratio and neutrophil phagocytosis, indicating improved immune function. These findings suggest that NBIW bathing improves mental stress, sleep quality, and immune function.
The variability of experimental capacity curve models for existing buildings and their within-building and between-building components.
Authors: Ghimire Subash , Guéguen Philippe
Published: July 2023

In this study, accelerometric data from seven Japanese buildings under long-term monitoring were analysed to explore the variability of the buildings’ co-seismic response over time and its within- and between-building components, using co-seismic capacity curves developed in acceleration-displacement-response-spectrum format. The data include the 2011 Tohoku Mw9.1 earthquake, which caused building damage of different levels of severity, and the time-varying actual capacity curves were analysed considering earthquakes before and after 2011. We observed that the initial slope of the capacity curves reflects the amount of damage. The between-building and within-building components of the variability are discussed by comparing a single building and several buildings in the same class for several earthquakes. Finally, the epistemic uncertainty of seismic risk assessment studies is discussed in relation to the selection of a generic capacity model for all buildings in a single class.