bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Bispecific Antibody CVL006 Superior to AK112 for Dual Targeting of PD-L1 and VEGF in Cancer Therapy
Authors: Wang Chunyan , Huang Hao , Song Zeng , Li Zhongyuan , Huang Jinwen , Cao Liang , Wu Ziai , Pan Junfang , Shen Xiaokun
Published: January 2025

Both preclinical and clinical studies have shown that combining anti-VEGF/VEGFR drugs with immune checkpoint inhibitors (ICIs) significantly enhances anticancer efficacy. Currently, PDL-1/ VEGF bispecific antibodies demonstrate superior antitumor activity compared to monotherapy or even the combination of PD-L1 inhibitors with anti-VEGF antibodies. This enhanced efficacy results from the simultaneous blockade of the PD-1/PD-L1 pathway and the inhibition of VEGF-driven angiogenesis. In this study, we developed a novel bispecific antibody, CVL006, by fusing an anti-PDL1 VHH domain with a humanized IgG1 anti-VEGF monoclonal antibody while retaining antibody-dependent cellular cytotoxicity (ADCC) functionality. CVL006 demonstrated high affinity and specificity for both human PD-L1 and VEGF, effectively blocking both the VEGF/VEGFR signaling pathway and the PD-L1/PD-1 axis. This dual blockade not only suppressed VEGF-induced angiogenesis but also reactivated T cells, increasing the secretion of cytokines essential for immune response. In vivo studies further indicated that CVL006 achieved superior antitumor efficacy compared to the PD-L1 inhibitor atezolizumab in mouse models, with greater tumor growth inhibition and reduced angiogenesis. To compare with approved bispecific antibody PD-1/VEGF AK112 (ivonescimab), CVL006 showed superior antitumor efficacy in vivo. These findings underscore the therapeutic potential of CVL006, which integrates immune checkpoint inhibition with disruption of tumor vascularization, offering a robust and comprehensive anticancer strategy.
Artistic and project creativity
Authors:   Institute of Pedagogy of the National Academy of Pedagogical Sciences of Ukraine, Vdovchenko Viktor
Published: January 2025

The scientific and methodological manual "Artistic and design creativity" is an innovative educational and methodological designer for the modern methodological level of training of a technology teacher. The manual contains the scientific, educational and methodological materials necessary for the new specialization. The scientific and methodological manual "Artistic and design creativity" can be successfully used by technology teachers, methodologists of district and city methodological offices, technology methodologists of regional institutes of postgraduate pedagogical education, and higher school teachers.
Features of implementing the content of technological education in grades 7-9
Authors:   Institute of Pedagogy of the National Academy of Pedagogical Sciences of Ukraine, Tarara Anatolii , Machacha Tetiana ,   Institute of Pedagogy of the National Academy of Pedagogical Sciences of Ukraine, Tutashynskyi Vasyl ,   Institute of Pedagogy of the National Academy of Pedagogical Sciences of Ukraine, Vdovchenko Viktor ,   Institute of Pedagogy of the National Academy of Pedagogical Sciences of Ukraine
Published: January 2025

The practical manual “Features of implementing the content of technological education in grades 7-9” is the result of the applied pedagogical research “Scientific and methodological support for implementing the content of technological education in gymnasiums”, conducted by the Department of Technological Education of the Institute of Pedagogy of the National Academy of Sciences of Ukraine during 2021-2023. The manual identifies features and provides recommendations on the methodology for implementing the content of basic technological education in the subject cycle of education, answers to questions that arise in the process of implementing the subject “Technology” in the New Ukrainian School. The methodological manual is intended for technology teachers, methodologists of postgraduate pedagogical education institutions, graduate students and students of pedagogical universities.
EMPOWERING THE SIDO MAJU FARMERS GROUP THROUGH THE DEVELOPMENT OF A SOLAR-POWERED CORN THRESHER
Authors: Ekoanindiyo Firman Ardiansyah , Kasmari Kasmari , Eniyati Sri , Hayati Enty Nur
Published: January 2025

This community service initiative seeks to enhance the design of a corn thresher to improve its functionality and expand its market potential. The activities include field inspections, discussions, training, and socialization with village officials, expert teams, and farmers' groups. Previous designs revealed several shortcomings, such as an intake hole positioned too high, causing user discomfort, and a small diameter that made it challenging to process larger corn cobs. Additionally, the separation mechanism between cobs and kernels was ineffective, leading to mixed results. Farmers also struggled with marketing their crops, often relying on traders visiting the village, which resulted in lower selling prices. The redesigned thresher addresses these issues by enabling upright operation, increasing intake capacity, and reducing costs through solar power. Complementing the redesign, online marketing training equips farmers with strategies to align their prices with market standards, reduce dependence on intermediaries, and enhance their income sustainably.
PENGARUH CITRA MEREK, IKLAN, DAN E-WOM TERHADAP KEPUTUSAN PENGGUNA APLIKASI SPOTIFY
Authors: Ayu Stephanie , Inggawati V. Ratna
Published: January 2025

Technological advancements have significantly impacted information consumption patterns, leading various information channels to modernize and adapt to user needs. Among these, radio has transitioned from a conventional audio medium to a digital platform. Digital radio, or streaming radio, allows users to access information flexibly, unrestricted by spatial and temporal limitations. This study aims to analyze the influence of brand image, advertising, and e-WOM on user decisions in choosing the digital radio application "Spotify." Using a quantitative approach, data was collected from Spotify users through an online survey. Results indicate that brand image, advertising, and e-WOM significantly impact user decisions, with brand image being the most dominant factor. Based on these findings, it is recommended that digital radio service providers enhance brand image, leverage advertising, and utilize e-WOM to retain user loyalty.
Transformasi Digital
Authors: Wijayantini Bayu , Arif Alfi , Sobri Taufik
Published: January 2025

Kemajuan teknologi informasi dan komunikasi mendorong munculnya digipreneurship sebagai pendekatan kewirausahaan inovatif yang berfokus pada pemanfaatan teknologi digital. Dalam konteks Revolusi Industri 5.0, integrasi manusia, teknologi, dan mesin semakin penting untuk meningkatkan daya saing bisnis. Digipreneurship memerlukan kreativitas dalam mengidentifikasi pasar niche, mengembangkan ide bisnis, serta menerapkan strategi pemasaran digital melalui platform yang relevan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan daya saing UMKM Bubuk Cabai "BukBe" di Kabupaten Bondowoso melalui pelatihan dan pendampingan berbasis digipreneurship. Tantangan utama yang dihadapi mitra mencakup keterbatasan dalam pemasaran digital, desain kemasan yang kurang menarik, dan minimnya pemanfaatan teknologi dalam strategi pemasaran. Program ini dilaksanakan selama empat bulan menggunakan metode Survei dan Analisis Kebutuhan, pelatihan digital marketing, pendampingan pembuatan konten pemasaran, serta implementasi strategi pemasaran digital melalui Instagram dan marketplace. Hasil kegiatan menunjukkan peningkatan kemampuan mitra dalam menyusun rencana pemasaran digital, memperbarui desain produk, dan memanfaatkan teknologi untuk memperluas pasar.Sebagai hasilnya, program ini berhasil meningkatkan kemampuan mitra dalam bersaing di dunia bisnis sekaligus mendorong pertumbuhan ekonomi kreatif berbasis potensi lokal di Bondowoso. Program ini diharapkan dapat menjadi inspirasi atau acuan bagi pengembangan UMKM lainnya dalam mempercepat proses transformasi digital guna mendukung pertumbuhan ekonomi yang berkelanjutan
Issues and Challenges of Cyber Security in India
Authors: Sanjay Kumar Gorai  , Sumit Behra  , Maheshwar Kumar
Published: January 2025

This study discusses how cyber security is playing an extremely vital role. It's been one of the hardest jobs during the current modernization,andpreserving privacy and information is a challenging task. The term 'Cyber Protection' has appeared as a nice idea, though its true meaning cannot be explained concisely; previously confused with terms related to anonymities, information sharing knowledge gathering, as well as monitoring. A data security frameworkis urgently required to protect the emerging infrastructure of today's information environment. ICT infrastructure is the common denominator of all critical national infrastructures. The international E-governance and E-commerce projects under implementation include a reliable cyber security infrastructure model. In this article, an effort is made to present a snapshot of this development and possible patterns and imperatives that emerge from this analysis in the sense of India.
Analysis of Differences in Stock Returns Before and After the Fatwa of MUI in Indonesia on Israel Affiliated Companies
Authors: Setiawati Ledy , Hidayati Widya Nur
Published: January 2025

Stock return are defined as the excess of the selling price of a stock over its purchase price. The higher the selling price of the stock than the purchase price, the higher the return that will be obtained, and vice versa. There are several factors that affect stock returns, one of which is government or organization policy which is an external factor. The existence of MUI Fatwa Number 83 of 2023 and the BDS movement that occurred in Indonesia are thought to cause differences in returns on Israeli-affiliated companies. The Israeli-affiliated companies sampled in this study were 4 companies. The results of the study show that there is no difference in stock returns in 4 affiliated companies before and after the MUI Fatwa Number 83 of 2023.
Розмежування підстав кримінальної відповідальності за державну зраду та колабора- ціонізм: історичний аспект
Authors: Герасимчук О. П. , Жуковська В. О.
Published: January 2025

У статті розглядається історичний аспект проблеми розмежування підстав кримінальної відповідальності за державну зраду та колабораціонізм, яка набуває особливої актуальності в умовах сучасних викликів національній безпеці України. У зв’язку зі збройною агресією з боку Російської Федерації та масштабними проявами співпраці громадян з окупаційною владою постає необхідність чіткого правового розмежування понять «державна зрада» та «колабораціонізм». Зокрема, у статті здійснено аналіз історичного розвитку інститутів кримінальної відповідальності за ці злочини, з урахуванням досвіду як українського права, так і міжнародних правових практик. Досліджується еволюція підходів до визначення державної зради та колабораціонізму в українському законодавстві, починаючи з давніх часів, часів Радянського Союзу і до сучасного періоду. Особливу увагу приділено порівняльному аналізу правових норм, що існували в різні історичні періоди, з метою виявлення основних тенденцій і змін у розумінні цих злочинів. Розглянуто також міжнародний досвід криміналізації колабораціонізму, зокрема у країнах Європи, які стикалися з такими викликами після Другої світової війни. Отже, стаття націлена на поглиблення розуміння юридичних підстав для розмежування державної зради та колабораціонізму, що сприятиме більш ефективному захисту національних інтересів і правосуддя в Україні.
Effect of antifreeze action products used to prevent frost damage during the vegetative and reproductive stages of common bean
Authors: Calderón-Tomás Celene , Díaz-Ruiz Ramón , Contreras-Ramos Juan , Pérez-Ramírez Efraín , Pérez-Armendáriz Beatriz , Álvarez-Gaxiola Jesús F.
Published: January 2025

Objective: To establish the frost damage to the stem and root nodules and protection degree of products with antifreeze potential, during the V2, V3, R6, and R7 phenological stages of bean.
Design/Methodology/Approach: Black beans with a type II indeterminate bushy habit were collected. Antifreeze (An), amino acids (Am), gibberellins (Gib) and their combinations were applied at 48-hour intervals. Subsequently, the plants were subjected to frost (0 °C) in a freezer for 1.5 h. Damage was evaluated in a 0 to 100% scale. The nodules were stained with 2,3,5-triphenyl tetrazolium chloride salt. Stained nodules were considered undamaged and non-stained nodules were considered damaged.
Results: Significant differences were found during the phenological stages and between the antifreeze action product treatments. Stage V3 was the most tolerant to frost, while stages R6 and R7 were the most susceptible. The number of undamaged and damaged nodules showed highly significant differences (p≤0.01) between phenological stages and between treatments, as well as in the total number of nodules. An and Ve+An recorded good effects, followed by Ve+Am. Gib was the least efficient product during the four stages.
Study Limitations/Implications: The increase of substances with antifreeze effect in different doses should be tested.
Findings/Conclusions: Frost caused different levels of damage in each phenological stage. V3 stood out as the most tolerant stage. All the products recorded different protection degrees during the phenological stages. Ve+An, An, and Ve+Am recorded the highest antifreeze action.
Exploring the Sobre Vote-buying in Rural Villages: The Lived Experiences of Poor Voters in the Philippines
Authors:   College of Business and Management Education, Sorsogon State University - Bulan Campus, Sorsogon, Philippines, Naz Graham , Fruto Bryan ,   College of Business and Management, Sorsogon State University - Sorsogon City Campus, Sorsogon, Philippines
Published: January 2025

Empirical evidence showed the prevalence of vote-buying in the country, particularly in rural areas targeting poor voters. This study explores the lived experiences of poor voters from rural areas on sobre vote-buying, the most prevalent type in the province. Semi-structured interviews were conducted by purposively selecting participants who experienced sobre vote-buying. Data gathered were analyzed through thematic analysis. Seven themes were developed to describe the participants' experience with sobre vote-buying. The study concluded that sobre vote-buying follows an established chain, keeps voters’ commitment, and furthers the patriarchal system. It likewise gauges the candidates’ seriousness to win. It is socially accepted due to its prevalence and justified by voter’s perception of rampant government corruption and inefficiency. To some extent, it remains an adequate inducement as participants lament the lack of trustworthy and competent candidates. The study recommends multisectoral voters' education, focusing on the ill effects of electing corrupt and incompetent officials.
AI in Anthem: A Comparative Analysis of the English and Filipino ChatGPT 4 Translations from the Existing Translations of the Philippine National Anthem
Authors:   Graduate School of Asia-Pacific Studies, Waseda University, Tokyo, Japan, Liwanag Lois Mauri Anne , Liwanag Gabriel Luis ,   Information Technology Department, De La Salle University, Manila, Philippines, Liwanag Leslie Anne ,   School of Innovation and Sustainability, De La Salle University Laguna Campus, Laguna, Philippines
Published: January 2025

This study analyzed ChatGPT's translation capabilities in Filipino and English. The original text was the Spanish poem 'Filipinas' by Jose Palma, which is the source language for the Philippine National Anthem and was translated by ChatGPT into Filipino and English. The translations generated by ChatGPT were then compared to the existing translations of the anthem, such as 1) 'Land of the Morning' by Osias and Lane in English and 2) 'Lupang Hinirang' by de Leon in Filipino. Translations generated by ChatGPT were evaluated using a Likert Scale to determine their proximity to or divergence from the identified existing translations. The analysis revealed that ChatGPT AI tool has the ability to construct its own linguistic structures and convey complex ideas to aid in a better understanding of the text. However, human discernment is still significant to guarantee translations align with the intended meaning, culture and context.
Introducción de los editores
Authors: Salazar Ortiz Victor Hugo , Oviedo Sotelo Daniel
Published: January 2025

El presente Dossier de Euphyía sobre Ética Ambiental y Animal reflexiona sobre la urgente necesidad de revisar nuestras teorías éticas tradicionales ante la crisis ambiental actual. Los editores destacan cómo la ética ha evolucionado desde su enfoque antropocéntrico hacia una consideración más inclusiva que abarca animales, ecosistemas y el entorno inorgánico. Este cambio surge frente a los impactos negativos de la industrialización y la explotación irracional de la naturaleza.
Los artículos abordan diversas perspectivas críticas. Entre ellos, se examinan las tensiones entre ecologismo y animalismo, las prácticas antropocéntricas históricas en relación con los animales, y las propuestas de ética ambiental basadas en la responsabilidad hacia futuras generaciones. También se analizan los desafíos éticos y políticos que plantea el cambio climático, como el desplazamiento climático y los derechos de las comunidades afectadas.
El dossier promueve una ética ampliada que reconozca la interconexión entre humanos y naturaleza, y que confronte los paradigmas especistas y antropocéntricos. Al hacerlo, busca fomentar una reflexión interdisciplinaria que inspire tanto el pensamiento filosófico como el activismo en pro de un planeta más sostenible y equitativo para todos sus habitantes.
La animalidad en el pensamiento de Nick Land o la línea de fuga hacia lo desconocido
Authors: Vargas Guevara Camilo Andrés
Published: January 2025

El presente texto intenta rastrear aquello que ha dicho Nick Land sobre lo animal o la animalidad en tanto vector de contagio de lo desconocido o de comunicación con el afuera. Para ello, presentamos inicialmente su lectura de Kant en tanto constructor de un aparato teórico que prohíbe el contacto con lo desconocido y el afuera. Luego, exponemos la interpretación que hace Land de algunos poemas de Trakl y de algunas figuras animales que aparecen en ellos en tanto formas de posibles devenires animales desterritorializadores.
Particle 11 Implications and Deployment (2024)
Authors:   Infinite 8 Industries, Inc., Colorado Springs, CO, 80909, United States, Mikale Ean , G Perera Darshika ,   Infinite 8 Industries, Inc., Colorado Springs, CO, 80909, United States
Published: January 2025

Particle 11, the top dark matter candidate out of 150 potential profiles, is a pioneering discovery in particle physics, potentially
bridging the gap between the Standard Model and Quantum Field Theory, while also being a strong dark matter candidate. Its
unique properties and unprecedented energy release—approximately 1.1002×10^21 times greater than a single kWh of a nuclear
plant—promise transformative advancements in energy storage and delivery systems. This particle's integration into the Standard
Model and Quantum Chromodynamics (QCD) enhances our understanding of fundamental forces and interactions. Despite significant
containment and safety challenges, Particle 11's potential applications span across drones, medical devices, robotics, autonomous
vehicles, and interplanetary travel. This discovery marks a profound new era of human scientific and technological progress.
Aprendizaje de prácticas gimnasticas para la inclusión de estudiantes con discapacidad auditiva a la educación física
Authors: Curicama Ayol Angel Geovanny , Quiñonez Panezo Maria Katherine , Loaiza Dávila Lenin Esteban , Maqueira Caraballo Giceya de la Caridad
Published: January 2025

Introducción.  La inclusión a la Educación Física es clave para garantizar la participación de estudiantes con discapacidad auditiva, superando barreras de comunicación y accesibilidad. Las prácticas gimnásticas adaptadas, mediante estrategias visuales y kinestésicas, promueven el desarrollo de habilidades motoras, la interacción social y la cohesión grupal. Objetivo.  Diseñar y a su vez validar un programa de aprendizaje de prácticas gimnásticas que promuevan la inclusión de estudiantes con discapacidad auditiva a la Educación Física. Metodología.  La investigación utilizó un enfoque mixto explicativo secuencial con un diseño preexperimental y fenomenológico. Se trabajó con 28 estudiantes, incluyendo una con discapacidad auditiva. La intervención, de 8 semanas, integró actividades adaptadas visuales y gestuales. Se aplicaron instrumentos de observación para medir dimensiones de inclusión y entrevistas semiestructuradas para un análisis cualitativo. Resultados. Los datos evidenciaron avances significativos en la inclusión en general, con un incremento en los valores promedio de 24,79 ± 6,69 en el pretest a 37,69 ± 3,48 en el post test (P = 0,05). Además, se observaron mejoras en cohesión grupal, comunicación y percepción positiva de las estrategias adaptativas implementadas, fortaleciendo la integración a la Educación Física. El análisis cualitativo reveló mejoras en cohesión grupal, comunicación y percepción de los participantes sobre las estrategias inclusivas. Conclusión.  El programa de prácticas gimnásticas adaptadas resultó efectivo para promover la inclusión de estudiantes con discapacidad auditiva a la educación física. Área de estudio general: Educación. Área de estudio específica: Educación Física Inclusiva. Tipo de estudio:  Artículos originales.
Achieving ‘Complete Justice’: A Comparative Study of the Constitutional Jurisprudence of India and Bangladesh
Authors: Abdullah Al Faruque  , Mohammad Moin Uddin
Published: January 2025

Both public policy and legal policy warrant that justice is delivered to the litigant people without any excuse. The power to do ‘complete justice’ avails the Supreme Court a vast residual power to complete the arc of justice by overcoming hurdles and roadblocks barring it from meeting the end of justice. The power is marked as an inherent and extraordinary discretionary power – not like other statutory discretionary powers – by virtue of which the Supreme Court can issue any decree or order for the end of complete justice subject to a few limitations. Article 104 of the Constitution of Bangladesh and Article 142 of the Indian Constitution empower the Appellate Division of the Supreme Court of Bangladesh and the Supreme Court of India respectively to exercise this power. Though the power is of wide amplitude being vested upon the apex court of the country by the constitution itself, it is nonetheless residual in nature. The contours of the power of ‘complete justice’ has remained a contentious issue in India—some arguing that the power can be exercised only restrictively, while others argue that the scope of the power is expansive. In absence of clear yardsticks to decide which situations entail the necessity of exercising the power, the power is still an enigma to the legal academia, though the Supreme Court of India seems to prefer liberal interpretation of the power. So, its ambit is wide and elastic enough to cover any new situation of necessity. Bangladesh Supreme Court has also exercised this power for a long time now, but no academic analysis of its journey has been undertaken so far. This article aims to elucidate the philosophy of devising the power and also to outline its scope and the trends of judicial interpretations in Bangladesh and India through a comparative analysis.

Dhaka University Law Journal, Vol. 35 (1), 2024 P. 1-30
Environment Court and Special Magistrate Court in Bangladesh: A Comparative Study
Authors: Hasan Md Golam Mostofa , Ullah Md Rahmat
Published: January 2025

Environment Court and Special Magistrate Court are two special courts to adjudicate environmental cases of both civil and criminal nature. They were constituted by the Environment Court Act, 2010 in order to prevent environmental degradation and punish environmental offenses under different environmental laws. But one decade later, it is seen that these special courts are unable to deliver what it was constituted for. The article aims to provide an overview of environmental governance in Bangladesh with an illustrative discussion of the adjudication process of environmental cases in Bangladesh. In that process, it will examine the major challenges, both legal and non-legal, that are creating hindrances to the eficient functioning of the Environment Courts and Special Magistrate Courts. It is concluded with recommendations with reformative measures for empowering the environment court and special magistrate court in Bangladesh based on the best practices of New Zealand, Australia, Philippines, and India, because the environment court and tribunals in these jurisdictions are considered as successful as being capable of model environment courts.
Dhaka University Law Journal, 2024, 35 (1), 87-112
Tingkat Dukungan Keluarga Dan Motivasi Diri Berhubungan Dengan Kepatuhan Diet Pada Penderita Hipertensi
Authors: Ina Lestari Nona , Supriyadi Supriyadi , Dewi Novita
Published: January 2025

The problem of hypertension increases every year, this is caused by many factors, one of which is still low dietary requirements. Actions to support diet compliance require family support and self-motivation. The aim of this research was to determine the relationship between family support and self-motivation with diet compliance in adult hypertensive sufferers at the Dinoyo Community Health Center, Malang City. The research design used cross sectional. The study population was 511 hypertensive sufferers with a total sample of 84 hypertensive sufferers. Samples were taken using the Accidental Sampling technique. The independent variables are family support and self-motivation, the dependent variable is compliance with hypertension. The instrument used is a questionnaire sheet. Data analysis used Fisher's exact test. The research results showed that the majority of respondents had good family support (67.9%). Almost all respondents have high self-motivation (91.7%). Most respondents had high diet compliance (50.7%). There is a relationship between family support (p=0.024; OR=3.3) and self-motivation (p=0.000; OR=0.3) with diet compliance in hypertension sufferers. Further research can conduct research directly examining family data regarding the family's.Masalah hipertensi setiap tahunnya mengalami peningkatan, hal ini disebabkan oleh banyak faktor salah satunya kepatuhan diet yang masih rendah. Tindakan untuk mendukung kepatuhan diet diperlukan dukungan keluarga dan motivasi diri. Tujuan penelitian ini untuk mengetahui hubungan dukungan keluarga dan motivasi diri dengan kepatuhan diet pada penderita hipertensi usia dewasa di Puskesmas Dinoyo Kota Malang. Desain penelitian menggunakan cross sectional. Populasi penelitian sebanyak 511 penderita hipertensi dengan jumlah sampel sebanyak 84 orang penderita hipertensi. Sampel diambil dengan teknik accidental sampling. Variabel independen adalah dukungan keluarga dan motivasi diri, variabel dependen adalah kepatuhan diet hipertensi. Instrumen yang digunakan berupa lembar kuesioner. Analisis data menggunakan uji fisher's exact test. Hasil penelitian menunjukkan sebagian besar responden memiliki dukungan keluarga yang baik (67,9%). Hampir seluruh responden memiliki motivasi diri yang tinggi (91,7%). Sebagian responden memiliki kepatuhan diet yang tinggi (50,7%). Ada hubungan dukungan keluarga (p=0,024; OR=3,3) dan motivasi diri (p=0,000; OR=0,3) dengan kepatuhan diet pada penderita hipertensi. Penelitian selanjutnya dapat melakukan penelitian tentang mengkaji secara langsung data keluarga.
Factors That Influence Patient Satisfaction In Using The HALODOC Application
Authors: Pujianto Melvin Dhanius , Wuisan Dewi Sri Surya
Published: January 2025

Mencari tahu bagaimana berbagai elemen bauran pemasaran memengaruhi kebahagiaan pasien dengan aplikasi Halodoc menjadi kekuatan pendorong penelitian ini. Teknik kuantitatif yang digunakan dalam pekerjaan ini meliputi analisis rute dan pendekatan serupa. Populasi penelitian adalah seluruh pengguna program Halodoc, sedangkan sampelnya berjumlah 168 responden. Metode pengumpulan data pada penelitian ini meliputi dokumentasi, angket, dan observasi langsung. Analisis regresi parsial yang sering disebut dengan Partial Least Square (PLS) digunakan untuk mengevaluasi hipotesis dalam penelitian ini. Pertama, produk tidak mempengaruhi kepuasan pasien terhadap Aplikasi Halodoc dengan cara, bentuk, atau bentuk apa pun; kedua, harga tidak mempengaruhi kepuasan pasien terhadap Aplikasi Halodoc dengan cara, bentuk, atau bentuk apa pun; ketiga, terdapat pengaruh yang signifikan terhadap kepuasan pasien terhadap Aplikasi Halodoc; dan keempat, promosi berpengaruh langsung terhadap kepuasan pasien terhadap Aplikasi Halodoc secara positif dan signifikan
Fragaria & Frangula Combination (FIBROMELT)
Authors: Zdravkov George
Published: January 2025

The article will present the indications, analyze of the component actions, cautions, and contraindications of the herbal formula Fragaria & Frangula Combination / Fibromelt /. The indications and analyze of the component actions will be done from the points of view of the Western and Traditional Chinese Medicines. The medical information of the Fragaria & Frangula Combination / Fibromelt / effectivity is done on the base of the 35 years practice of the author.
Acne in Adolescents: How Emotional Support Improves Treatment Outcomes
Authors: Kibitska Hanna
Published: January 2025

The article is devoted to an urgent problem among adolescents acne, which significantly affects both the physical condition of the skin and psycho-emotional health. The paper discusses the physiological causes of acne, symptoms, and areas of localization of the disease, as well as its impact on self-esteem, social adaptation, and quality of life of adolescents.

Particular attention is paid to the comparative characterization of the psychological adaptation of adolescents and adults to standard acne treatments. Adolescents demonstrate greater vulnerability of the nervous system and emotional instability, which complicates the perception of therapy. Compared to adults, adolescents are more likely to need additional explanations about the importance of treatment, as well as psychotherapeutic support to increase motivation and reduce stress. Adult patients, due to their emotional resilience, adapt to therapy more quickly and more easily accept temporary side effects. The proposed interdisciplinary approach to treatment includes the cooperation of a dermatologist, cosmetologist, and psychologist, where the dermatologist develops an individualized medication regimen, the cosmetologist provides skin care, and the psychologist provides emotional support aimed at reducing stress, increasing self-esteem and forming a positive attitude towards therapy.

It is important to introduce treatment methods in stages, including initial psychological and cosmetic preparation, which reduces the risk of side effects and increases patient motivation. This approach not only helps to eliminate acne symptoms, but also stabilizes the psychological state, which significantly improves the quality of life of adolescents and guarantees a long-term result. The introduction of an integrated approach into clinical practice is an effective means of combating acne, especially for the category of adolescents who need more attention to the emotional component of therapy.
Knowledge and Awareness of Sudanese and Chinese Dentists towards Cone-Beam Computed Tomography (CBCT)
Authors: Abdalla Hashim Mohamed Hayder , Zo Rui , Hashim Mohamed Hayder A
Published: January 2025

Aim: The study aimed to assess and compare the knowledge and awareness of Sudanese and Chinese general dental practitioners and orthodontists regarding Cone-Beam Computed Tomography (CBCT).

Subject and method: A total of 294 participants were enrolled, predominantly consisting of Dentist under 30 years old, with a majority being female (73.8%). Around half of the participants were Sudanese (52.4%), and the rest were Chinese (47.6%). The majority were general practitioners (74.8%), with the remaining 25.2% being orthodontists. It was conducted as a descriptive cross-sectional hospital-based study, utilizing a questionnaire to collect data on participants' knowledge and awareness of CBCT.

Results: The study found that more than 200 participants had poor knowledge of CBCT, defined as scoring less than 50% on knowledge questions. Notably, 80% of Chinese participants and 69.5% of Sudanese participants had poor knowledge, indicating a significant association between nationality and knowledge level (p < 0.05).

Conclusion: CBCT represents an advanced imaging technique with considerable potential in dentistry, a fact increasingly recognized by dental specialists. However, the study revealed a significant gap in knowledge and awareness of CBCT applications among participants, with a particular emphasis on the need for training in this field. Nationality and job position were also found to be significantly associated with knowledge levels, underscoring the importance of addressing these disparities in future education and training initiatives.
The Positive Impact of Dental Care Coordination Across an Interdisciplinary Population Spectrum in a Large Urban Health Center Setting
Authors: Cassandra Wright , Sandra Coley
Published: January 2025

Introduction: The oral health report card on pregnant women and children in the US is concerning. According to the American Dental Association (ADA), expectant mothers face an increased risk of gingivitis and caries due to changes in hormones and diet, compounded by the effects of morning sickness, nausea, and vomiting on oral hygiene [1].CDC (Centers for Disease Control and Prevention) say that tooth decay is the most common chronic childhood disease in the US, with more than half of children ages six to eight having had a cavity in at least one baby tooth [2].

Unity Health Care, Inc., a federally qualified health center (FQHC) in Washington, DC, launched a project in 2019 to address social determinants of health across a spectrum of inner city health center patients. To improve access to dental care for underserved populations, they introduced the role of CDHCs (community dental health coordinators) in several of their health centers to navigate patients to dental care.

Methods and Materials: Unity’s one-year project to coordinate dental care for underserved populations began with the recruitment of candidates for CDHC training. Upon graduation, the CDHCs implemented a four-pronged approach to navigate targeted patients (pregnant women, children ages nine and under, seniors with diabetes, and people with HIV with comorbidities into the three phases of dental care: emergent/acute, preventive, and restorative.

Results/Conclusions: Despite COVID’s impact on recruitment, the CDHC care coordination model proved successful: 460 patients were navigated into initial care with CDHCs and an impressive 72.83% requested additional support. During the project term, 15% (69) were in progress or had completed Phase 1 treatment (acute/pain); 66.31% (305) were in progress or had completed Phase 2 treatment (preventive); and 9.34% (43) were in progress or had completed Phase 3 treatment (restorative).
Rutaecarpine Modulates IL-1? and iNOS Expression in LTA-Induced Macrophages: A Confocal Microscopy Analysis
Authors: Hsia Chih-Hsuan , Cheng Ssu-Wei , Hsieh Fang-I , Lien Li-Ming
Published: January 2025

Macrophages are essential immune cells involved in maintaining physiological homeostasis and mediating pathological responses. Activation of macrophages by lipoteichoic acid (LTA) from Gram-positive bacteria triggers inflammatory pathways, leading to the production of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and inducible nitric oxide synthase (iNOS). Understanding the regulation of these pathways is crucial for developing therapeutic strategies for inflammatory diseases. Our previous study has demonstrated that rutaecarpine (Rut), an alkaloid from the traditional Chinese medicinal herb Evodia rutaecarpa, can modulate inflammatory responses in macrophages. This study further investigates the effects of Rut on LTA-induced activation of RAW 264.7 macrophages, focusing on cell morphology, IL-1β secretion, and iNOS expression. Cell morphology was observed using a phase-contrast microscope, and IL-1β and iNOS expressions were assessed using immunofluorescence staining and confocal microscopy. The results showed that Rut treatment did not alter the morphology of RAW 264.7 cells at concentrations up to 20 μM. At 20 μM, Rut significantly inhibited LTA-induced IL-1β secretion and iNOS expression in macrophages. Confocal microscopy revealed that LTA stimulation markedly increased IL-1β and iNOS fluorescence intensities, which were significantly reduced by Rut pre-treatment. These findings suggest that Rut effectively inhibits LTA-induced inflammatory responses in RAW 264.7 macrophages by reducing IL-1β secretion and iNOS expression without affecting cell morphology, highlighting its potential as a therapeutic agent for treating inflammatory diseases associated with Gram-positive bacterial infections.
Plasmacytoid Dendritic Cells Display Surface but Not Membrane-Bound IgE Across a Broad Range of Total Serum IgE Levels
Authors: Chen Jonathan , MacGlashan Donald , McCormack Amanda , Schroeder John , Tversky Jody
Published: January 2025

Introduction: Plasmacytoid dendritic cells (pDC) are unique antigen-presenting cells that may be implicated in allergic disease because they bind IgE on their surface and modulate important Th1/Th2 cytokine responses. The authors previously discovered that IgE is not readily removed from pDCs using omalizumab to the same extent observed for basophils, suggesting that a portion of the IgE on pDCs may be membrane bound.

Methods: A cross-sectional study was performed and recruited adult volunteers from Johns Hopkins Asthma & Allergy Clinic, Baltimore, Maryland, USA, between 2022–2023. Individuals with varying levels of serum IgE were selected, and those on subcutaneous immunotherapy or biologic therapy were excluded. Basophils and pDCs were isolated using established protocols. In order to isolate peripheral blood mononuclear cells, blood was also drawn from consenting donors with a wide range in total serum IgE levels. B cells and pDCs were identified by flow cytometry by gating on CD19/CD27 and blood dendritic cell antigen 2/CD123, respectively. Quilizumab, a mouse anti-human monoclonal IgG1 antibody with specificity only for membrane-bound IgE and surrogate for omalizumab, was used to detect this molecule in both cell types.

Results: When used in vitro at 1.5 mg/mL, omalizumab removed ~80–90% of the IgE expressed by basophils. In contrast, IgE expression decreased only 30–40% on similarly treated pDCs. There was no significant difference in the number of pDCs staining for membrane-bound IgE between the isotype control and quilizumab (P=0.125, 0.165). However, the proportion CD19+27+ B cells staining for quilizumab compared to other PBMC was 54:1 (P=0.015).

Conclusion: While pDCs express significant levels of surface-bound IgE, there is no appreciable amount of membrane-bound IgE noted. The reason for omalizumab’s poor ability to remove pDC-bound IgE compared to its effectiveness at removing circulating IgE remains unknown.
Inside Hybridization of CF/PAEK Hollow Profiles by Means of Injection Molding
Authors: Würfel Veit , Becke Johannes Antonio , Dutzke Lars , Mischorr Eric , Heinze Philipp , Keil Johannes , Liebsch Alexander , Gude Maik , Garthaus Christian , Assmann Fabian
Published: January 2025

Hollow profiles made of braided thermoplastic tape material are able to meet the demands of future aviation applications in terms of cost, cycle time and mechanical properties of structural components. By using the overmolding technology additional elements, i.e. load introductions, can be formed onto the hollow profile, increasing its functionality. This work presents a novel processing route for a driveshaft load introduction design of hollow profiles, whereby the load introduction element is injection molded onto the inside of a thermoplastic hollow profile. To form the contour of a splined shaft of the injection molding part inside the hollow profile, a collapsible core is used in conjunction with a ring gate. In order to ensure a proper bonding between the injection molding material and the composite, the hollow profile is heated externally in an infrared oven and then transferred into an injection molding tool for the functionalization step. This process set up requires a precise adjustment of the wall thickness of the hollow profile, the contour of the collapsible core and the process temperature. Extensive processing trials are performed on different temperatures and laminate configurations. Photomicrographs, computer tomography scans and mechanical tests are used for evaluating the part quality.
Novel Field-Manufacturing Methods for Long-Fiber Thermoplastic Composites
Authors: Haller, Jr. James C. , Clark Jacob C. , Gayton James T. , Hunter Michael S. , Schanck Andrew P. , Sheltra Cody A. , Davids William G. , Lopez-Anido Roberto A. , Lapp Justin L.
Published: January 2025

Continuous fiber reinforced thermoplastics (CFRTPs) are valued for their high strength-to-weight ratios, corrosion resistance, and recyclability over traditional structural materials. However, CFRTPs are difficult to fabricate compared to thermoset composites, a significant barrier to their adoption in construction and infrastructure. The University of Maine’s Advanced Structures and Composites Center has developed several innovative manufacturing and post-processing techniques to address fabrication challenges. The Continuous Forming Machine (CFM) is a processing device for non-reactive thermoplastic pultrusion, efficiently producing structural profiles like rods, plates, and channels. The CFM platform can be expanded with co-processes to create parts such as field-bendable concrete reinforcing bar. Further, effective post-forming processes will be crucial for adapting CFRTP components to on-site infrastructure applications. Localized thermoforming targets specific bending regions within a CFRTP component, offering a field-friendly approach over stamp thermoforming. Using localized heating methods, such as embedded heating elements, CFRTP panels can be locally thermoformed into three-dimensional components. Additional work has been performed to mitigate wrinkle formation in the bending of thick-gauge CFRTP laminates by implementing modifications to component architecture. This research presents significant advancements towards the widespread adoption of CFRTPs for infrastructure, demonstrating the technology's adaptability for onsite manufacturing and its future impact on sustainable construction practices.
Efektivitas Pemberian Jahe Merah (Zingiber Officinale Var Rubrum Rhizoma) Dan Teh Rosella (Hibiscus Sabdariffa) Terhadap Kegawatan Dismenore
Authors: Puji Setya Rini Puji Setya Rini , Diah Agustina  , Tiwi Pramesti
Published: January 2025

Teenagers start to experience menstruation is one form of adolescence with biological development. Abdominal pain which is often called dysmenorrhea pain is often experienced by teenagers who are menstruating. The use of red ginger and rosella tea is one form of non-pharmacological treatment to reduce dysmenorrhea pain. The purpose of this study was to determine the effectiveness of red ginger and rosella tea in reducing dysmenorrhea in adolescent girls. The research method used a Quasy Experiment with a nonrandomized pretest - posttest approach, in this study design using 3 (three) groups, namely the group with the treatment of red ginger decoction, the group with the treatment of rosella tea and the control group. The sample in this study was the red ginger intervention group, the rosella tea intervention group and the control group with 30 respondents each. The results of the study were obtained using the Mann Whitney alternative test, a p value of 0.000 was obtained, meaning that statistically red ginger provided effectiveness on the dysmenorrhea pain scale in the intervention group. The conclusion statistically red ginger provided significant effectiveness on the pain scale in the intervention group with a p value of 0.000 (<0.05).
Edukasi Kesehatan Reproduksi Dengan Menggunakan Media EMIVO
Authors: Putri Al Zahra  , Muhammad Imadudin Akbar  , Beatrix Elizabeth
Published: January 2025

Remaja saat ini sering melakukan kesalahan yang dapat mengakibatkan perilaku seksual yang menyimpang karena kurangnya pengetahuan tentang kesehatan reproduksi. Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan kesehatan reproduksi dengan EMIVO (Edukasi Media Video) terhadap tingkat pengetahuan kesehatan reproduksi remaja usia 10-12 tahun di SDN Karang Sentosa 02. Penelitian ini menggunakan metode kuantitatif dengan desain penelitian Pre-Experimental Pretest-Post Test Only One Group Design dengan menggunakan teknik purposive sampling, dengan jumlah populasi 158 siswa dan sampel 61 siswa. Berdasarkan hasil data yang diperoleh peneliti menunjukkan bahwa dari 61 responden, paling banyak 26 orang (42,6%), berusia 12 tahun dengan jenis kelamin perempuan sebanyak 35 orang (57,4%), total dari 61 responden, sebanyak 41 orang (67,2%) siswa di SDN Karang Sentosa 02 memiliki pengetahuan baik sebelum diberikan pendidikan kesehatan reproduksi melalui EMIVO (Education Media Video) dan, sebanyak 61 orang (100%) memiliki pengetahuan baik setelah diberikan pendidikan kesehatan reproduksi melalui EMIVO (Education Media Video). Hasil penelitian menunjukkan bahwa pendidikan kesehatan reproduksi dengan video berpengaruh positif terhadap pengetahuan kesehatan reproduksi remaja di SDN Karang Sentosa 02. Dengan nilai p tingkat kepercayaan 95% sebesar 0,014<0,05.
IMPLEMENTASI MODUL ARIS (ANXIETY AND DEPRESSION REDUCTION THROUGH ISLAMIC SPIRITUAL CARE) DALAM MEMENUHI KEBUTUHAN SPIRITUAL PASIEN
Authors: Citra Wisuda Aris , Suraya Citra , Emiliasari Dian
Published: January 2025

Spiritualitas merupakan kebutuhan dasar bagi setiap individu. Pasien yang menjalani perawatan, terutama dengan kondisi kronis, kritis, atau terminal, sering kali merasa cemas terhadap rasa sakit, ketidakpastian, dan kematian. Bagi pasien dalam kondisi tersebut, spiritualitas menjadi sumber utama ketenangan dan kekuatan pemulihan. Modul ARIS (Anxiety and Depression Reduction Through Islamic Spiritual Care) dikembangkan sebagai panduan untuk memenuhi kebutuhan spiritual pasien melalui pendekatan Islami yang terstruktur. Studi ini bertujuan mengeksplorasi implementasi pelayanan keperawatan spiritual menggunakan modul ARIS, khususnya bagi pasien yang mengalami kecemasan dan depresi. Metode yang digunakan mengikuti Model Kirkpatrick, meliputi pemaparan teori, penjelasan konsep spiritual care, serta sesi role play. Kegiatan ini berlangsung selama empat minggu dengan pasien yang mengalami penyakit kronis di Rumah Sakit Islam Siti Khadijah Palembang pada 2024, melalui sesi diseminasi dan praktik langsung. Hasil analisis menunjukkan modul ARIS efektif dalam memenuhi kebutuhan spiritual pasien, sehingga menurunkan kecemasan dan depresi mereka. Modul ini berisi panduan beribadah, doa kesembuhan, dan murottal Al-Quran, yang dinilai lengkap dan praktis oleh perawat dan pasien. Modul ARIS direkomendasikan sebagai sarana pelayanan spiritual untuk mendukung asuhan keperawatan profesional yang komprehensif dan holistik.