bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECTIVENESS OF INTERCULTURAL COMMUNICATIVE LANGUAGE TEACHING (iCLT) MODEL FOR LEARNING INTERCULTURAL COMMUNICATION: A CASE STUDY
Authors: Nurhidayah Almalia
Published: May 2022

Abstract: This study to find out the effectiveness of the effectiveness of the intercultural communicative language teaching model (iCLT) in EFL students' learning experiences of intercultural communication. This study used qualitative research as Methodology and used in-depth information using a variety of data collection, such questionnaires and interviews as research design. The research of this study was held in the second semester in the academic year of 2020/2021. The data was taken from the third grade of of English Education Department on a Private University in Cirebon. The result showed that the the implications of teaching intercultural communicative language (iCLT) on intercultural communication, it can be concluded that most of the effectiveness of the iCLT model in intercultural communication learning is very positive. They gain new learning experiences, understand their own identity in relation to others, and do not adopt a new cultural identity. Even Though, there are still the strengths and weaknesses of each teaching step (Input Notice Practice Output) in the ICLT model. And each step of teaching is part of the ICLT model which aims to accommodate them to become intercultural speakers with ICC and be able to communicate and socialize effectively. and appropriate with other people from different cultures and countries.Keywords: Intercultural Communicative Language Teaching(iCLT) Model, Intercultural Communication (IC), Teaching Step, Intercultural Communicative Competence (ICC), Intercultural.
Speech Acts Analysis of The Main Characters on Amy Tan's "The Joy Luck Club"
Authors: Mariani Nanik , Rini Sulistyo , Satrio Adrie
Published: May 2022

Abstract: This study tries to describe how speech acts are applied through the main character in The Joy Luck Club. It is broken down into: (l) a description of the types of illocutionary speech acts performed, (2) a description of how the speech acts are carried out which is also translated into two sub-objectives, namely: (I) a description of how the illocutionary acts are performed; and (2) a description of how the perlocutionary act was carried out. The description of the types of illocutionary acts is based on Searle's category of illocutionary acts which is also used as a category for the actual meaning of an utterance. While the forms are based on the syntactic form of the sentence. While the perlocutionary act is said to be effective if the speech act has an influence on the thoughts, actions, or feelings of the listener in accordance with what was intended by the speaker. To answer these research questions, a qualitative research design was carried out. Data was collected from the language use of the main characters in Amy Tan's novel, The Joy Luck Club. Then, dialogues, monologues, and actions were collected, breed Sctibed, and analyzed. The results showed that the type and highest meaning used by the main character was representative. Meanwhile, in terms of form, most use declarative. Moreover, the perlocutionary acts produced are mostly ineffective.  Abstract: This study tries to describe how speech acts are applied through the main character in The Joy Luck Club. It is broken down into: (l) a description of the types of illocutionary speech acts performed, (2) a description of how the speech acts are carried out which is also translated into two sub-objectives, namely: (I) a description of how the illocutionary acts are performed; and (2) a description of how the perlocutionary act was carried out. The description of the types of illocutionary acts is based on Searle's category of illocutionary acts which is also used as a category for the actual meaning of an utterance. While the forms are based on the syntactic form of the sentence. While the perlocutionary act is said to be effective if the speech act has an influence on the thoughts, actions, or feelings of the listener in accordance with what was intended by the speaker. To answer these research questions, a qualitative research design was carried out. Data was collected from the language use of the main characters in Amy Tan's novel, The Joy Luck Club. Then, dialogues, monologues, and actions were collected, breed Sctibed, and analyzed. The results showed that the type and highest meaning used by the main character was representative. Meanwhile, in terms of form, most use declarative. Moreover, the perlocutionary acts produced are mostly ineffective. Keywords:  Speech Act, Type, Meaning, Form, Illocutionary Act,
Analysis on the Formation and Operation of a New Folk Relief System --- Taking the Flood Relief in Zhejiang Province in 1922 as an Example
Authors: Jiang Chen’an
Published: May 2022

The flood in Zhejiang in 1922 led to numbers of disaster victims. In the case of insufficient government relief, non-governmental organizations had become the main force in disaster relief, and in the process of disaster relief, a new model had gradually formed with relief fundraising as the core and various small and medium-sized organizations united around it. Under this model, the disaster relief process and results showed many different characteristics from the past and set a typical model for future charitable relief movements.
Analysis on the Reform of Physical Education Teaching in Medical Colleges From the Perspective of “Integration of Sports and Medicine”
Authors: Bi Yansong
Published: May 2022

Through the method of literature review, this paper analyzes the social background of the integration of body and medicine, the advantages of the integration of body and medicine in medical colleges, and the reform ideas of physical education in medical colleges to practice the integration of body and medicine. It is considered that the practice of integration of sports and medicine should be based on medical colleges and give full play to the advantages of teachers and students in medical colleges, and the practice of integration of sports and medicine involves physical education teaching purposes, teaching contents, teaching methods, teaching process, teaching evaluation, physical education textbooks and other aspects.
A Study on Improving the Ethnic Identity of Southeast Asian Chinese Children in the Post-Epidemic Era: A Case Study of the "Xunwei Jia Geng Love" Chinese Online Course
Authors: Zhong Yi , Lin Anqi
Published: May 2022

Chinese language teaching is booming and the Chinese language is gradually going global, and more and more Chinese expatriates are paying more attention to the education of their children's "roots". This paper draws on the teaching theory of the "cultural triangle" to design an online Chinese cultural education resource that is both contemporary and historical, in order to strengthen Chinese children's sense of national identity and cultural pride.
BURDUR PALEOLİTİK ÇAĞ YÜZEY ARAŞTIRMASI-2021
Authors: FINDIK Betül , MAYDA Serdar , DEMİREL Fatma Arzu , PARMAK Rıdvan Can
Published: May 2022

Burdur’un daha önce Paleolitik Çağ açısından yeterince araştırılmamış olması, konumu ve coğrafyası nedeniyle olası potansiyeli göz önüne alınarak 2021 yılında “Burdur İli Paleolitik Çağ Yüzey Araştırması”na başlanmıştır. 2021 araştırma sezonunda Bucak ve Kemer ilçelerinde yürütülen arazi çalışmalarında yaygın yaya yüzey araştırması yöntemi uygulanmıştır. Ekibimiz, uygun alanlarda 5’er metre aralıklarla yürüyerek arazi taraması yapmıştır. Ancak araştırma alanlarımızın daha çok, dağlık, kayalık ve yer yer sık çalı örtülerinin bulunduğu alanlardan oluşması nedeniyle bu yöntem yalnızca tarla, bahçe gibi düzlük alanlarda uygulanabilmiştir. Araştırma sonucunda, elde edilen yontmataş bulgular daha çok Alt ve Orta Paleolitik dönemlere ait özellikler göstermektedir. Bununla birlikte Paleolitik Çağ’ın daha geç dönemlerine işaret eden az sayıda bulgu da mevcuttur. Gerek Bucak gerekse Kemer’de yapılan araştırmalar net olarak dönemsel ayrımlar yapmaya olanak verecek karakteristik bulgular vermemiştir. Her iki alanda devam edecek çalışmaların yeni bulgularla, daha net sonuçlar vereceği kanısındayız.
YÜKSEK TEKNOLOJİ İHRACATI BELİRLEYİCİLERİNİN PANEL ARDL ANALİZİ İLE İNCELENMESİ
Authors: KALKAN Yusuf , PALA Fahrettin
Published: May 2022

Ülkelerde, ekonomik iyileşme ve sürdürülebilir ekonomik büyümenin sağlanması büyük ölçüde ihracata ve özellikle yüksek teknoloji ihracatına bağlıdır. Teorik ve ampirik yaklaşımlı birçok çalışmada, yüksek teknoloji ihracatının hacmi ve performansı ile ilişkili faktörler tespit edilmiştir. Bu çalışmanın amacı ise önceki çalışmalarda tespit edilen bazı faktörler ile yüksek teknoloji ihracatı arasındaki ilişkiyi Yüksek-Orta gelirli ülkeler düzeyinde değerlendirmeye çalışmaktır. Bu amaç doğrultusunda uygun veriye sahip 26 yüksek-orta gelirli ülkenin 2000-2019 yılları arasındaki dönemi panel ARDL yöntemiyle analiz edilmiştir. Analiz sonuçlarına göre yüksek teknoloji ihracatı ile araştırma ve geliştirme harcamaları (Ar-Ge), brüt sermaye oluşumu, ticari açıklık ve ekonomik özgürlük indeksi değişkenleri arasında uzun dönemde pozitif bir ilişki tespit edilirken doğrudan yabancı yatırım (DYY) ile negatif bir ilişki bulunmuştur. Kısa dönemde ise değişkenler arasında ilişki olmadığı görülmüştür.
FENOMENAL İFŞANIN İNŞASI OLARAK POSTYÖNETİM: BİR DİSTOPİK YÖNETİMBİLİM DENEMESİ
Authors: PAPATYA Gürcan
Published: May 2022

Makale, yönetimbilimde postlaşma sorun/salının değerini ortaya koyma ve sorun/salın geçerliliğine ve gerçeklenebilirliğine dair kararı verme, olası düşüncelerin istikametini görme ve gösterme motivasyonunu oluşturma ve açıklamaları yapma kapsamında keşfi bir araştırmadır. Araştırmada yönetimbilimde postlaşma yaklaşımı açıklanmış, sürücü kavram postyönetim kurgusu, çevresi ve biçimleri tanıtlanarak iki çerçeveleme yapılmıştır. Bu çerçeveleri postyönetim çevresine taşımak ve kurgulamak için yönetimsizlik, transyönetim, holografik yönetim formları öne çıkartılarak incelemiştir. Ancak/o halde distopya izlenmiş, ziyadesiyle gelecekte yönetimbilim negatiflikleriyle nasıl başa çıkılacağını göstermeye ilişkin yürütülmüştür. Böylece yönetimbilim yolunda gayretleri değerlendirme ve gelecekteki yeri hakkında düşünme, keşfetme ve biçimlendirme düşüncesine dair kapsam ortaya konmuştur. Sonuçta ileri araştırmalar için “Aceleci Çağda Postyönetim içerimi”ni tartışma ya da keşfi araştırmanın ikinci boyutu hipotez oluşturma girişi vurgulanmıştır.
Information Theory of Gravity
Authors: Abanto Jeffrey Alloy
Published: May 2022

A new model of gravity is presented here similar to the earlier work of Verlinde on Emergent Gravity but without the use of thermodynamic assumptions. The theory does not use the main assumption of Verlinde on the nature of gravity as an entropic force using the First Law of Thermodynamics. Moreover, it does not use the Equipartition Theorem such that there is no need to define a thermal bath enclosed within a holographic screen. Instead of Equipartition Theorem, the theory uses $E=NE_{p}$, for the total energy of a massive object where $E_{p}$ is the Planck Energy while $N$ is the number of Planck Energy to represent the maximum possible density of information that can reside in matter. The theory uses also the Holographic Principle as the basis for an information-theoretic approach to the nature of gravity. It is shown here that gravity emerges whenever there is an updating of the information within a given volume of space by the presence of matter.
Analysis of the Infiltration Complex System Using a Novel GSA-Hybrid for Automatic Calibration Focused at Civil Construction
Authors: Aguero_Martinez Domingo_Stalin , Murari Thiago , Moret Marceelo
Published: May 2022

Among the various complex systems that we experience each day, there is the physical phenomenon of infiltration. Infiltration is considered as the dynamics of water flow in the subsurface soil that in this work is framed for the context of civil construction. This issue is approached with the use of mathematical models and stochastic techniques, however, there are hardships in collecting the samples in the field, the adoption of a scale type, the influence in soil layers interfaces, the effects of soil anisotropic characteristics and so on. In this study, methodology is proposed to deal with the soil sampling input such as the retro model, constitutive model and optimization algorithms. Additionally, an automatic calibration is set forth to fix parameters from the mathematical model submitted. Especially among the existing Optimization Algorithms there are Genetic Algorithms and the Generalized Simulated Annealing Algorithm (GSA). This work presents an overview of these optimization methods and a proposal for a more efficient and faster algorithm called GSA-HYBRID based on convergence gradient technique. The applied strategy depends on the type of case study considering its physical properties and constraints. In this sense, it is found that while Genetic Algorithms are able to replicate the optimization surface, Generalized Simulated Annealing is much more adequate in characterizing the system at an extremely low computational cost. Nevertheless, the hybrid technique GSA-HYBRID performed the fastest. Further research is necessary to implement the novel GSA-HYBRID algorithm due to its flexibility and higher speed, also, studying its application at different case studies.
Divergent Conceptualization of Embodied Emotions in English and Chinese Languages
Authors: Zhou Pin , Critchley Hugo , Nagai Yoko , Wang Chao
Published: May 2022

Empirical and theoretical advances in human neuroscience have led to a reappraisal of the relationships between mind, brain and body, the implications of which are particularly relevant to understanding emotions, which is revealed to be embodied owing to the facts that they are on the one hand primarily arise from the internal bodily states controlled by interoceptive system, on the other they give rise to physiological reactions and physical action evoked by autonomic nervous system. More specifically, when considering the ‘embodied mind’ (i.e., how mental processes are inescapably contextualized by their location within the body), the brain, instead of the ‘master’ of the body, is increasingly revealed to function as the ‘servant’, with its primary goal to maintain the body’s homeostatic integrity. This is achieved through the control of interoceptive information concerning body’s physiological state, initially as ‘simple’ organ-level homeostatic reflexes and then through higher-order coordination across organ-systems allowing ‘allostatic policies’ to predict and maintain future health of the integrated whole ‘biological-self’. In this context, motivational and emotional feelings arise from interoceptive signals that accompany (motivational and emotional) internally-directed physiological responses, and externally-directed behaviors. Emotion concepts are thus the categorized embodied outcomes of bidirectional brain-body interactions and may arguably be differentiated into afferent interoceptive processes, i.e., from body to brain, and efferent/autonomic processes, i.e., from brain to body. When comparing emotion words used in Chinese and English languages, afferent/interoceptive processes seem to dominate conceptualization of embodied emotions in Chinese, while the efferent processes feature more commonly in English. The presence of distinct conceptual systems relating to emotions may, according to the linguistic relativity hypothesis as well as the theory of constructed emotion, significantly shape the distinct values and ‘national character’ of Chinese and English–speaking cultures. Correspondingly, it is argued that, in the expression of affective traits, Chinese-speaking people are biased towards being more receptive, reflective and adaptive, whereas native English speakers may tend to be more reactive, proactive and interactive. These patterns also encompass functions historically ascribed to bodily organs by traditional Chinese and ancient Greek medicine.
Removal of Diclofenac-Na from Aqueous Solution onto H3PO4 Modified Composite Clay
Authors: Ajani Ayobami , Adeniji Ademola , Ayodabo Samson , Alade Abass , Afolabi Tinuade , Ganiyu Sofiat
Published: May 2022

Under batch experiment conditions, this work seeks to successfully remove Diclofenac-Na (DCF-Na) from an aqueous solution utilizing a composite sorbent made of Bentonite, Kaolinite clay, and Worm casting (BKW). This study investigated the structural modification of the H3PO4 Modified Clay by X-ray fluorescence and the effect of selected adsorption factors – DCF-Na concentration and modified BKW composite dosage. The concentration equilibrium data was used to study six isotherm models. Freundlich isotherm model better explained the adsorption of DCF-Na onto modified BKW composite with a correlation coefficient close to 1. Kinetics models were examined, and the Elovich model gave a better fit than other kinetic models studied. Mass diffusion mechanisms and thermodynamics studies were successfully carried out. The enthalpy change values evaluated were negative, which revealed the spontaneity of DCF-Na remediation onto modified BKW, and that DCF-Na adsorption is exothermic and occurred through a physisorption process.
Improvement in the Multiple Sclerosis Functional Composite Score by Multi-Function Swing Suspension Training Program
Authors: Sepehri far Sara , Amiri Banafsheh , Sahebozamani Mansour , Ebrahimi Hossein Ali
Published: May 2022

Background: Physical activity has been considered as a promising approach to slow down the disease process in Multiple Sclerosis (MS) patients. While the functional impairments of MS have been studied in detail, but there is limited evidence of the efficacy of exercise interventions on the Multiple Sclerosis functional composite (MSFC) score in these patients. The study aim was to in-vestigate the improvement in MSFC score by multi-function swing suspension training (MFSST) in the women with MS. Methods: The patients were divided into the intervention and control groups. A total of 47 MS patients completed the MSFC components at baseline and after the intervention. Z scores were created for each test based on control means. Results: The MSFC components showed a significant increment in comparison with the baseline levels in the four, six, and eight weeks following the first exercise session (all p<0.05). These dif-ferences in the control group were not significant. The improvement in the MSFC score and the component Z-scores in the intervention groups was found from the fourth week onwards. Conclusions: The study findings highlight that MFSST can be used as an effective treatment method in MS patients due to its positive effects on physical parameters, such as muscles strength, functional impairments, and cognitive problems.
Anisotropy of the E Effect in Ni-based Magnetoelectric Cantilevers: A Finite Element Method Analysis
Authors: Hähnlein Bernd , Sagar Neha , Honig Hauke , Krischok Stefan , Tonisch Katja
Published: May 2022

Magnetoelectric sensors based on microelectromechanical cantilevers consisting of TiN / AlN / Ni are investigated using finite element simulations in regard of the anisotropy of the E effect and its impact on the sensor sensitivity. The E effect is derived from the anisotropic magnetostriction and magnetization of single crystalline Nickel. The magnetic hardening of Nickel in saturation is demonstrated for the (110) as well as the (111) orientation. It is shown further, that magnetostrictive bending of the cantilever has a negligible impact on the eigenfrequency and thus sensitivity. The intrinsic E effect of Nickel decreases in magnitude depending on the crystal orientation when integrated into the magnetoelectric sensor design. The transitions of the individual magnetic domain states are found to be the dominant influencing factor on the sensitivity for all crystal orientations. The peak sensitivity was determined to 41.3 T-1 for (110) in-plane orientated Nickel at a magnetic bias flux of 1.78 mT. It is found, that the transition from domain wall shift to domain rotation along the hard axes yields much higher sensitivity than the transition from domain rotation to magnetization reversal. The results achieved in this work show that Nickel as hard magnetic material is able to reach almost identical sensitivities as soft magnetic materials, such as FeCoSiB.
Research Business Model Innovation of Exponential Organizations—Take MI as an Example
Authors: Zhang Xuming , Li Peng , Chun Dongphil
Published: May 2022

As a representative of Exponential Organizations, MI went from obscurity to the Fortune 500 in just ten years. Mi's success is inextricably linked to its outstanding business model. This paper summarizes the elements of MI's business model from four perspectives: value proposition, value creation, value delivery, and value capture, as well as its measures for developing into an exponential organization. Expecting to provide theoretical references for the transformation and upgrading of manufacturing organizations.
Extraction and Purification of Melanin From Various Cells and Tissues
Authors: Kurian Noble K
Published: May 2022

Melanins are phenolic biopolymers synthesised by most of the living organism mainly for photoprotection or surviving in harsh conditions. Melanin is localised in different areas or complexed with different other biomolecules when observed from animals to microbes. This makes the melanin extraction procedure different in animal, plant and microbial tissues. Basically, the alkali-acid extraction is used in most protocols of which slight variations are there depending on the tissue used. This review will try to compile melanin extraction procedures from different cells and tissues ranging from animals to bacteria.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 21.05.2022 г.по 27.05.2022 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Зимирова Анастасия , Осина Наталья , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: May 2022

В обзоре представлена информация по актуальным геновариантам вируса SARS-COV-2, циркулирующим в настоящее время, геномные последовательности которых размещены в международной базе данных GISAID за неделю с 14.05.2022 г.по 20.05.2022 г.
El terremoto de 1940 y su impacto en las condiciones de salud en Lima y Callao
Authors: Aparcana Puquio Paula , Carcelén Reluz Carlos , Morán Daniel , Acuña Barrueto Miriam
Published: May 2022

A lo largo de su historia, las ciudades de Lima y Callao han sido afectadas por una serie de sismos. El 24 de mayo de 1940 sufrieron un gran terremoto de grado 7,9 en la escala de magnitud de momento (Mw). Fue el sismo de mayor magnitud del siglo XX y el segundo en intensidad desde la fundación de la ciudad y el terremoto y tsunami de 1746, que destruyó completamente ambas ciudades. El objetivo de esta investigación es analizar su impacto en las condiciones de salud de la población de la capital. Debido a la intensidad del sismo y los materiales de construcción habitualmente utilizados, causó gran destrucción en la infraestructura antigua de la ciudad y afectó especialmente a la población de los sectores populares.
Las lluvias extraordinarias de 1818 a través de la correspondencia del doctrinero de Cajabamba
Authors: Castañeda Murga Juan , Trujillo Coronado Isaac
Published: May 2022

A partir de la correspondencia del doctrinero de Cajabamba José Perea con el notario eclesiástico Fernando Pesantes, se aborda en este artículo las impresiones de Perea acerca de las lluvias ocurridas en 1818 y se las contrasta con datos sobre alteraciones climáticas en otros lugares del Perú y del mundo que sucedieron en ese mismo año. En medio de un contexto de temor e incertidumbre por la invasión de las tropas rioplatenses a la capitanía general de Chile, Perea expresó su malestar por la prolongación de la estación lluviosa desde noviembre de 1817 hasta agosto de 1818. Tras un breve lapso, empezaron nuevamente las precipitaciones y ello le impidió continuar con las obras de refacción de la iglesia matriz de aquel pueblo. Se concluye la ocurrencia de un evento de El Niño Oscilación del Sur en ese año.
El Corvo: un caso de discurso xenófobo y nacionalista en un contexto de violencia, Tarapacá, 1919
Authors: Rivera Olguin Patricio , Herrera Salinas Jenny , Sanchez Espinoza Eugenio
Published: May 2022

El artículo analiza el contenido de El Corvo, periódico pasquín que circuló en la región salitrera de Tarapacá en el norte de Chile en 1919. El contexto es el de la denominada «chilenización», durante la posguerra del Pacífico, en una zona de conflicto y anterior al Tratado de Lima en 1929. Este estudio centra su objetivo en el análisis del discurso presente en las columnas de El Corvo y establece categorías que evidencian la vulgarización y violencia descrita en este medio escrito hacia el habitante peruano de Tarapacá, entendido como un otro por parte de esta editorial. Asimismo, se examinan y describen las estructuras lingüísticas generales (categorías lingüísticas, macroacciones y usos retóricos) y su respectiva correlación con los estereotipos fijados para la población peruana asentada en la región salitrera y específicamente en Iquique (Chile). Se logra establecer la existencia de una cobertura informativa que se basa en la construcción de un habitante tarapaqueño original de estos espacios que es inferiorizado culturalmente a la ocupación chilena de estos territorios
La participación de las comunidades indígenas en la Guerra del Pacífico (1881-1884). Análisis historiográfico y perspectivas de investigación (1979-2022)
Authors: Abanto Chani Julio César
Published: May 2022

El objetivo de este artículo es evidenciar el rol de las comunidades indígenas en la construcción de una idea de nación alternativa, que surgió en medio de la Guerra del Pacífico, particularmente durante la agudización del conflicto bélico: entre la caída de Lima (1881) y la firma de Tratado de Ancón (1883). Para ello, nos apoyaremos en un recorrido historiográfico con los aportes y el seguimiento a la trayectoria de la discusión de diversas posiciones, que nos muestre sus inicios, el panorama actual y las perspectivas de futuro en esta temática. De esta manera, analizaremos diversos estudios realizados por los investigadores Heraclio Bonilla, Florencia Mallon, Nelson Manrique, Mark Turner, Nelson Pereyra, Hugo Pereyra y Brooke Larson, entre otros. Finalmente, evaluaremos la producción de tesis universitarias sobre la guerra con Chile de estas dos últimas décadas, para identificar el nivel de incidencia de las comunidades campesinas dentro de los estudios históricos.
Short-Term Field Research on Air Pollution within the Boundaries of the Large City in the Baltic Region
Authors: Chlebnikovas Aleksandras , Paliulis Dainius , Bradulienė Jolita , Januševičius Tomas
Published: May 2022

Air quality in urban and suburban areas is strongly affected by the level of local urbanization, climatic conditions and industrial activity. Monitoring the main air pollutants such as nitrоgеn оxidеs, cаrbоn mоnоxide and particulatе mаttеr may help control thе most polluted areas of the site and take measures to reduce pollution. Uncontrolled emissions from other chemical pollutants, including volatile organic compounds and odorous contamination sources like ammonia may cause both a chronic human disease and damage to flora and fauna. The conducted field research is aimed at determining air pollution within the areas of the large city (residential territory, recreation territory and the areas close to intense transport streets) polluted with the gaseous pollutants of varying nature (CO, NO2, ozone, sulfur dioxide, VOC and NH3) as well as particulate matter in different seasons of the year. Studies on Vilnius district air quality were carried out in 17 urban locations (points) and based on two-phase measurements. The first phase was initiated in 2016–2017 and the second one took place in 2019–2020. It was observed that in the areas close to intense transport streets, the concentration of pollutants can increase more than 3 times, thus reaching up to 36.0 µg/m3 of PM10 (particulate matter) and up to 48.0 µg/m3 of nitrogen dioxide. During the summer period, ammonia concentrations can increase up to 3 times, reaching up to 11.0 µg/m3 from farming and/or industrial activities.
Spontaneous rupture of renal angiomyolipoma in twin pregnancy, surgical management with fetal preservation: a case report
Authors: Rulaniya Suresh , Neniwal Vishal , Bhalothia Shweta , Agarwal Piyush , Hota Datteswar
Published: May 2022

Introduction: Renal Angiomyolipomas are rare in pregnancy.They have tendency to grow in size leads to rupture and occasionally fatal because of hormonal imbalance. Our case report is aim to report the management strategy during first week of pregnancy. Case presentation: A 29 years female presented in her 11 weeks of gestation following ovulation induction with right flank pain which increased in severity recently.Radiological scans revealed 16x12 cm expanding mass suggestive of ruptured right renal AML. We have managed with a multidisciplinary approach and right open nephrectomy was performed in lieu of symptoms with serial ultrasound showed increased retroperitoneal collection in size. The histopathology revealed renal angiomyolipoma. On table and postoperative obstetrics scan revealed two live fetuses without any stress. Letter cesarean section was performed at 35 weeks without any complications. Conclusion: Ruptured renal angiomyolipoma is rarer with twin pregnancy.Multidisciplinary approach resulted in successful nephrectomy without concurrent delivery, allowing the pregnancy to proceed to term.
Mental Health First Aid Experiences: A Qualitative Investigation into the Emotional Impact of Mental Health First Aid Responsibilities
Authors: Cook Amy , Keyte Rebecca , Sprawson Isabella , Matharu Amrita , Mantzios Michail
Published: May 2022

Mental health is leading to rising costs to the economy and increasing strain on professional healthcare services. Mental Health First Aid (MHFA) is an effective tool to support people with ill mental health. This study explored the experiences of MHFA volunteers to increase knowledge of how to support them. Twelve students who had successfully completed the two-day MHFA training course participated in a semi-structured interview. Being a Mental Health First Aider (MHFAer) was a responsibility highly valued by participants, however the anxiety that accompanies this role was paramount within the data. It was clear to see the compassionate nature of MHFAers, however it was apparent that for many participants this was at the expense of self-compassion. This study suggests a need to enhance the support materials for MHFA volunteers, alongside a model of compassionate self-care for enhancing personal coping, health and wellbeing.
The zinc ionophore clioquinol reduces Parkinson’s disease patient-derived brain extracts-induced neurodegeneration
Authors: Teil Margaux , Doudnikoff Evelyne , Thiolat Marie-Laure , Bohic Sylvain , Bezard Erwan , Dehay Benjamin
Published: May 2022

Parkinson’s Disease (PD) is characterized by intracellular α-synuclein-rich protein aggregates, named Lewy Bodies (LB), and by the progressive loss of dopaminergic neurons in the substantia nigra. Several heavy metals, including zinc (Zn), have been suggested to play a role in PD progression, although the exact role of Zn in neurodegeneration remains to be fully elucidated. To address this gap, we investigated the effects of Zn modulation on the progression of degeneration in mice injected with PD patient-derived LB-extracts carrying toxic α-synuclein aggregates. Zn modulation was achieved using either a clioquinol-enriched diet, a Zn ionophore that redistributes cellular Zn, or a Zn-enriched diet that increases Zn levels. Clioquinol treatment significantly prevented dopaminergic neurodegeneration and reduced α-synuclein-associated pathology in LB-injected mice, while no differences were observed with Zn supplementation. Biochemical analyses further demonstrate that the expression levels of vesicle-specific Zn transporter ZnT3 in the striatum of LB-injected mice treated with clioquinol were decreased, suggesting an intracellular redistribution of Zn. Additionally, we found that clioquinol modulates the autophagy-lysosomal pathway by enhancing lysosomal redistribution within the neuronal compartments. Collectively, we found that in vivo pharmacological chelation of Zn, by dampening Zn-mediated cytotoxicity, can result in an overall attenuation of PD-linked lysosomal alterations and dopaminergic neurodegeneration. The results support zinc chelation as a disease-modifying strategy for treating PD.
SIRT4 functions as a tumor suppressor in prostate cancer by inducing apoptosis and inhibiting glutamine metabolism
Authors: Cai Liangliang , Ge Zhuhui , Xu Yunqiu , Sun Pingliang , Huang Guoyu
Published: May 2022

SIRT4, localized in the mitochondria, is an nicotinamide adenine dinucleotide (NAD+) -dependent adenosine diphosphate (ADP) -ribosyltransferase and is one of the least characterized members of the sirtuin family. Although it is well known that it shows deacetylase activity for energy metabolism, little is understood about its function in tumorigenesis. Recent research suggests that SIRT4 may work as both a tumor suppressor gene and an oncogene. However, the clinical significance of SIRT4 in prostate cancer remains unknown. In this study, we evaluated SIRT4 protein levels in cancerous prostate tissue and corresponding non-tumor prostate tissue via immunohistochemical staining on a tissue microarray including tissues from 89 prostate cancer patients. The association between SIRT4 expression and Gleason score was also determined. Further, shSIRT4 or stable prostate cancer cell lines (22RV1) overexpressing SIRT4 were constructed via lentiviral infection. Using Cell-Counting Kit-8 (CCK-8) assay, wound healing assay, migration, and invasion and apoptosis assays, the effects of SIRT4 on the migration, invasion ability, and proliferation of prostate cancer cells were investigated. We also determined the effect of SIRT4 on glutamine metabolism in 22RV1 cells. We found the protein levels of SIRT4 in prostate cancer tissues were significantly lower than those in their non-neoplastic tissue counterparts (P < 0.01); a lower SIRT4 level was also significantly associated with a higher Gleason score (P < 0.01). SIRT4 suppressed the migration, invasion capabilities, and proliferation of prostate cancer cells and induced cellular apoptosis. Furthermore, the invasion and migration of 22RV1 cells were mechanistically inhibited by SIRT4 via glutamine metabolism inhibition. In conclusion, the present study's findings showed that SIRT4 protein levels are significantly associated with the Gleason score in patients with prostate cancer, and SIRT4 exerts a tumor-suppressive effect on prostate cancer cells by inhibiting glutamine metabolism. Thus, SIRT4 may serve as a potential novel therapeutic target for prostate cancer.
Electrooxidation and subcritical water oxidation hybrid process for pistachio wastewater treatment
Authors: Isik Zelal , Jabbiyev Zhalaladdin , Bouchareb Raouf , Ozay Yasin , Yabalak Erdal , Dizge Nadir
Published: May 2022

In this study, a hybrid system was used for pistachio wastewater treatment based on the electrooxidation treatment process and subcritical water oxidation. The effects of current density (50–150 A/m 2 ), experiments time (0–180 min), and wastewater initial pH (4-8) were optimized for maximum total phenols and chemical oxygen demand (COD) removal. The experimental study proved that the best conditions of current density and solution pH for COD and total phenol removal efficiencies were 150 A/m 2 and original pH of 5 giving removal efficiencies of 50% and 19.02%, respectively. The electrochemically pretreated wastewater was subjected to subcritical water oxidation (SWO). The effects of temperature (376–410 K), treatment time (26.4-93.65 min), and concentration of H 2 O 2 (0.08-0.92 M) were examined for COD and total phenol removal. The experimental and predicted COD and total phenol removal of the central composite design (CCD) models demonstrated that temperature, treatment time and concentration of H 2 O 2 have highly affected each of COD and total phenol removals. The highest removal efficiencies were as much as 54.3% and 76.87% for COD and total phenol at the following optimum conditions: temperature of 403 K, 40 min of treatment time and 0.75 M of H 2 O 2 concentration. The SWO results showed that, although treatment time affects the removal yields, it is not as effective as hydrogen peroxide concentration. In addition, it was found that COD and total phenol removal yields at the lowest values of all variables remained at 18.36% and 44.58%, respectively. Besides, they increased to 42.17% and 53.17%, respectively, by increasing only treatment time to its highest level. However, further increasing the treatment time after a specific level, may not increase the removal yields. Nevertheless, higher removal rates in both COD and total phenol were achieved even in the lowest level of the treatment time, but the highest level of the other two variables.
Capturing SARS-CoV-2 from patient samples with low viral abundance: a comparative analysis
Authors: Fonseca Juliana Pipoli da , Kornobis Etienne , Turc Elodie , Enouf Vincent , Lemée Laure , Cokelaer Thomas , Monot Marc
Published: May 2022

Since the beginning of the SARS-CoV-2 coronavirus pandemic, genome sequencing is essential to monitor viral mutations over time and by territory. This need for complete genetic information is further reinforced by the rapid spread of variants of concern. In this paper, we assess the ability of the hybridization technique, Capture-Seq, to detect the SARS-CoV-2 genome, either partially or in its integrity on patients samples. We studied 20 patient nasal swab samples broken down into five series of four samples of equivalent viral load from CT25 to CT36+. For this, we tested 3 multi-virus panel as well as 2 SARS-CoV-2 only panels. The panels were chosen based on their specificity, global or specific, as well as their technological difference in the composition of the probes: ssRNA, ssDNA and dsDNA. The multi-virus panels are able to capture high-abundance targets but fail to capture the lowest-abundance targets, with a high percentage of off-target reads corresponding to the abundance of the host sequences. Both SARS-CoV-2-only panels were very effective, with high percentage of reads corresponding to the target. Overall, capture followed by sequencing is very effective for the study of SARS-CoV-2 in low-abundance patient samples and is suitable for samples with CT values up to 35.
Comparison of four commercially available thyroid peroxidase autoantibody and two thyroglobulin autoantibody assays
Authors: Wolffenbuttel Bruce H.R. , Wouters Hanneke J.C.M , Kobold Anneke C. Muller , Roozendaal Caroline , Klauw Melanie M.
Published: May 2022

Background:
Measurement of thyroid peroxidase autoantibodies (TPOAb) is used to confirm a diagnosis of Hashimoto’s hypothyroidism. Presence of TPOAb may predict future thyroid dysfunction, and is also associated with adverse pregnancy outcomes and worse quality of life.
Methods:
We evaluated the performance of four TPOAb and two thyroglobulin antibodies (TgAb) assays in 71 patients with a presumed or established thyroid disorder with a large variety of TPOAb concentrations (range < 33-3204 IU/ml, originally measured with Thermo Fisher Phadia Cap assay). In addition, we reviewed the reference values of all assays. These samples were re-measured with the Abbott ARCHITECT, Roche Cobas and Phadia EliA assays, and also evaluated for TgAb with BRAHMS TgAb KRYPTOR and Phadia TgAb EliA. Passing-Bablok regression analysis plots were created to assess the differences between the assays.
Results:
Of 18 individuals negative for TPOAb with the Phadia Cap, three were positive with Abbott Architect, and four with both the Roche Cobas and Phadia EliA. All individuals with detectable TPOAb > 33 IU/ml in the Phadia Cap also had detectable levels with the three other assays. In general, these other assays reported 1.2-1.8x higher TPOAb concentrations than the Phadia Cap. Five of the 18 individuals with negative TPOAb showed positive TgAb with the Brahms, and 5 with the Phadia EliA assay. Of the 53 individuals with detectable TPOAb with Phadia Cap, 11 did not show TgAb with the Brahms assay, and 13 with the Phadia EliA. Overall, the correlation between both TgAb assays was poor.
Conclusions:
Different TPO and Tg auto-antibody assays quantitively and qualitatively yield different results. These differences may have consequences for daily clinical practice.
Explore the attitudes of children and adolescent parents towards the vaccination of COVID-19 in China
Authors: Wang Lin , Wen Wen , Chen Chen , Tang Jiake , Wang Chunyi , Zhou Mengyun , Cheng Yongran , Zhang Xingwei , Wang Mingwei , Feng Zhanhui , Wang Weiqian
Published: May 2022

Background
With the increasing incidence of asymptomatic carriers or milder symptoms, children and adolescents are likely to become a silent source of infection. In view of the efficacy and safety of vaccines in the treatment of novel Coronavirus pneumonia, population-wide vaccination will be an inevitable trend to control the spread of COVID-19. However, there is no survey on the attitudes of Chinese parents of children and adolescents towards their children's COVID-19 vaccination.
Methods
We used online questionnaires to find out the attitudes of Chinese parents toward their children's immunization against COVID-19. Logistic regression was used to explore the influencing factors.
Results
A total of 2019 parents participated in the survey. Overall, 74.38% parents said they would actively get vaccinated, 8.90% refused to get vaccinated, 4.60% said they would delay vaccination and 12.12% were still undecided.
Conclusions
In general, Chinese parents have a high desire to be vaccinated against COVID-19, and most parents have a positive attitude towards their children's vaccination. However, many people still hesitate or even refuse to be vaccinated. Education background, attitudes towards children's vaccination, children's age, recent illness and other factors have a certain impact on Chinese parents of children and adolescents towards their children's COVID-19 vaccination.
The effect of Thiazolidinediones on the vascular endothelium and plaque in diabetic patients with coronary atherosclerosis：a meta-analysis
Authors: Xue Cheng-Yuan , Zhou Meng-Qi , Zheng Qi-Yan , Cheng Wei-Ting , Bai Xue-Hui , Zhang Jin-Hui , Zhou Fen , Wu Ai-Ming , Nie Bo , Liu Wei-Jing , Lou Li-Xia
Published: May 2022

Rosiglitazone (Avandia) and Pioglitazone (Actos) belong to the class of thiazolidinedione drugs that act by increasing insulin sensitivity and are widely used for treating diabetic patients with insulin resistance. Thiazolidinediones (TZDs) exhibit anti-inflammatory and antioxidant properties and inhibit endothelial cell inflammation and dysfunction, and then play a role in inhibiting plaque formation and coronary atherosclerosis. But the results of evidence-based medicine suggest that thiazolinedione may increase the risk of myocardial infarction. To explore the dispute in depth, the meta-analysis aimed to evaluate the changes in vascular endothelial and plaque-related indicators following treatment with thiazolidinediones on diabetic patients with coronary atherosclerosis.According to our meta-analysis, Thiazolinediones showed a protective effect on the vascular endothelium and an inhibiting effect on plaque progression in patients with diabetes and coronary atherosclerosis and these effects may not depend on related targets or pathways such as inflammation and lipid regulation. Due to the poor quality of the evidence, more and higher-quality studies are needed to further improve the above conclusions.
Variables associated with progression of moderate-to-severe Crohn’s disease
Authors: Sacramento Carolina da Silva Beda , Motta Marina Pamponet , Alves Candida de Oliveira , Mota Jaciane Araujo , de Codes Lina Maria Goes , Liberato Renata Nobrega Cordeiro , Ferreira Reginaldo Freitas , Silva Pedro de Almeida , Palmiro Larissa do Prado , Barbosa Rafael Miranda , Andrade Mariana Nery , Andrade Vitor Damasceno , Vasconcelos Vitor Brandão , Thiara Bernardo Wasconcellos , Netto Eduardo Martins , Santana Genoile Oliveira
Published: May 2022

Objective: Currently, variables associated with Crohn’s disease progression remain insufficiently investigated in developing countries. Thus, this study aimed to determine the variables associated with hospitalizations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, surgical recurrence, and immunobiological agent use.Results: A retrospective cross-sectional study was conducted from 2019 to 2021, using two centers for inflammatory bowel diseases in the Brazilian Public Health System. This study included 220 patients. Perianal disease was associated with hospitalization. Stricturing or penetrating behavior and perianal disease were associated with surgery. Ileal or ileocolonic location and stricturing or penetrating behavior were associated with intestinal resection. Furthermore, steroid use at first Crohn’s disease occurrence and postoperative complications were associated with hospital readmission and surgical recurrence, respectively. Age below 40 years at diagnosis, upper gastrointestinal tract involvement, and perianal disease were associated with immunobiological agent use. These findings are similar to those in the countries with a high prevalence of Crohn’s disease, and could be applicable in other developing countries. Knowing these variables is useful in identifying the severity profile of Crohn’s disease and selecting the most appropriate management and treatment.
Peppermint (Mentha piperita) extract modulates the genotoxic effects of Cypermethrin and Malathion insecticides on Allium cepa root cells
Authors: Amin Osman Ali Hag El , Nosiar Hala Ragab , Ibrahim Rashid Ismael Hag
Published: May 2022

The potential protective effect of peppermint (Mentha piperita; Labiatae) water extract was investigated on onion (Allium cepa) root tips that were exposed to cytotoxic and genotoxic insecticides; cypermethrin or malathion. Cypermethrin was tested at 0.019, 0.038 and 0.075mg/ml and malathion at 0.235, 0.469 and 0.938mg/ml, based on concentrations used in the field. Parallel doses of 4µg/ml or 8µg/ml peppermint extract were applied for each insecticide treatment, while distilled water was used as a control. Exposure time was 8 hours for all treatments. Mitotic index (MI), cell proliferation kinetics (CPK), percentage of mitotic aberrations (MAs) and nuclear aberrations (NAs) were evaluated. Both insecticides exerted a significant decline in MI (p < 0.001) and mitotic kinetics aberrations, which indicated potent cytotoxicity of both insecticides even at lower doses, where significant reduction of MI (more than 50% below the control) because of prophase imbalance and metaphase arrest. Both insecticides induced a concentration dependent MAs ranging between 19.0 and 29.6%. MAs and TAs of cypermethrin were significant at the high dose, while those caused by malathion were significant at both medium and high doses. Aberrations observed included bridges, vagrants, laggards, stickiness, multipolar, binucleated cells, micro-, lobed, blebbed and vacuolated nuclei. Application of peppermint water extract to both insecticides reduced the cytotoxic and genotoxic capacity of these insecticides.