bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomarkers of Hand Osteoarthritis Are Detectable after Mechanical Exercise
Authors: Bender Anna , Kaesser Ulrich , Eichner Gerrit , Bachmann Georg , Steinmeyer Juergen
Published: September 2019

Background: Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample venous blood, and (c) to correlate biomarker levels with radiological and clinical scores. Methods: Four female cohorts were investigated. One with a more Heberden-accentuated OA and one with a more Bouchard-accentuated hand OA, and two symptom-free control groups aged 20–30 or 50–75 years. The venous blood was sampled before and at eight time points after mechanical exercise of the OA hand. X-rays of OA hands were assessed using the Kellgren and Lawrence as well as Kallman scores. Participants were evaluated clinically using the AUSCAN™ Index, visual analog scale (VAS), and Health Assessment Questionnaire (HAQ). Serum levels of seven biomarkers were measured by ELISA. Results. The concentrations of CPII, COMP, IL-15, sVCAM-1, NGAL, and PIIANP were significantly increased within 15 min after exercise. PIIANP was markedly elevated in the Heberden-accentuated OA group as compared to both control groups, but did not correlate with any radiological or clinical score. Analysis of the probabilistic index further revealed that CPII can distinguish between Bouchard’s OA and premenopausal controls whereas COMP can discriminate between Bouchard’s and Heberden’s OA. Conclusions: This study demonstrates that even previously undetectable biomarkers can be quantified in serum after mechanical exercise. Future larger studies are needed to determine specificity and sensitivity of these markers and their ability to diagnose even pre-radiological OA.
Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis?
Authors: Duitman JanWillem , van den Ende Tom , Spek C. Arnold
Published: September 2019

Idiopathic pulmonary fibrosis is a rare, progressive and fatal lung disease which affects approximately 5 million persons worldwide. Although pirfenidone and/or nintedanib treatment improves patients’ wellbeing, the prognosis of IPF remains poor with 5-year mortality rates still ranging from 70 to 80%. The promise of the anti-cancer agent nintedanib in IPF, in combination with the recent notion that IPF shares several pathogenic pathways with cancer, raised hope that immune checkpoint inhibitors, the novel revolutionary anticancer agents, could also be the eagerly awaited ground-breaking and unconventional novel treatment modality limiting IPF-related morbidity/mortality. In the current review, we analyse the available literature on immune checkpoint proteins in IPF to explore whether immune checkpoint inhibition may be as promising in IPF as it is in cancer. We conclude that despite several promising papers showing that inhibiting specific immune checkpoint proteins limits pulmonary fibrosis, overall the data seem to argue against a general role of immune checkpoint inhibition in IPF and suggest that only PD-1/PD-L1 inhibition may be beneficial.
Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
Authors: Lin Yu-Hsiang , Hou Chen-Pang , Juang Horng-Heng , Chang Phei-Lang , Chen Tien-Hsing , Chen Chien-Lun , Tsui Ke-Hung
Published: September 2019

The associations between the treatment outcomes of benign prostatic hyperplasia/benign prostatic obstruction and lifelong health status, including urologic cancer incidence as well as geriatric adverse events (AEs), are unknown. This retrospective cohort study analyzed claims data collected during the period of 1997–2012 from Taiwan’s Longitudinal Health Insurance Database 2000. Patients who received transurethral resection of the prostate (TURP) were prioritized, and the remaining patients who were prescribed alpha-blockers were, subsequently, identified. Patients in the TURP and medication-only groups were further divided into two groups, according to the presence or absence of AEs during the first six-month follow-up. Outcomes of primary interest were all-cause mortality, occurrence of prostate cancer, transurethral resection of the bladder tumor, and radical cystectomy for bladder cancer. Compared with patients in the AE-free TURP group, those in the TURP with AEs had a higher risk of lifelong bladder cancer (subdistribution hazard ratio: 2.3, 95% confidence interval (CI): 1.56–3.39), whereas the risk of prostate cancer was comparable between the two groups (SHR: 1.2, 95% CI: 0.83–1.74). In the medication cohorts, patients undergoing alpha-blocker treatment who had AEs had a higher risk of all-cause mortality (hazard ratio: 1.63, 95% CI: 1.49–1.78) and a higher risk of lifelong bladder cancer (SHR: 2.72, 95% CI: 1.99–3.71) when compared with those without AE. Our study reveals that unfavorable treatment outcomes of benign prostate hyperplasia, whether caused by medication or surgical treatment, are associated with a higher incidence of bladder cancer. Unfavorable outcomes of surgical treatment are associated with higher risk of geriatric AEs, and unfavorable outcomes of medication treatment are associated with a higher risk of all-cause mortality.
Human Soluble Recombinant Thrombomodulin, ART-123, Resolved Early Phase Coagulopathies, but Did Not Significantly Alter the 28 Day Outcome in the Treatment of DIC Associated with Infectious Systemic Inflammatory Response Syndromes
Authors: Mori Shusuke , Ai Tomohiko , Sera Toshiki , Ochiai Kanae , Otomo Yasuhiro
Published: September 2019

Disseminated intravascular coagulation (DIC) is a catastrophic systemic disorder of coagulation, resulting in uncontrollable bleeding, multiple organ failure, and death. Sepsis is one of the common causes of DIC. Despite many attempts to correct these coagulation pathologies, no adjunctive treatments have been shown to improve the mortality of DIC associated with sepsis. Although some clinical studies showed a recently developed human recombinant thrombomodulin, ART-123, might be effective in the treatment of DIC, few randomized, placebo-controlled studies have been conducted. In this study, we treated 60 DIC patients associated with systemic inflammatory response syndrome (SIRS) using ART-123 (n = 29) or saline as a placebo (n = 31). The basal clinical characteristics were similar in both groups. We compared clinical severity scores and DIC score in acute phase, and 28 day mortality between the two groups. Our study demonstrated the DIC score improved a few days earlier in the ART-123 group than the placebo group, and there were no major life-threatening adverse events in both groups. The overall survival rate at day 28 was not significantly altered. In conclusion, ART-123 can be used safely in DIC associated with infectious SIRS patients; however, its true efficacy in the treatment of DIC needs to be further investigated.
Elucidating the Efficacy of the Bacille Calmette–Guérin Vaccination in Conjunction with First Line Antibiotics and Liposomal Glutathione
Authors: Abrahem Rachel , Cao Ruoqiong , Robinson Brittanie , Munjal Shalok , Cho Thomas , To Kimberly , Ashley David , Hernandez Joshua , Nguyen Timothy , Teskey Garrett , Venketaraman Vishwanath
Published: September 2019

Mycobacterium tuberculosis (M. tb) is the etiological agent that is responsible for causing tuberculosis (TB). Although every year M. tb infection affects millions of people worldwide, the only vaccine that is currently available is the Bacille Calmette–Guérin (BCG) vaccine. However, the BCG vaccine has varying efficacy. Additionally, the first line antibiotics administered to patients with active TB often cause severe complications and side effects. To improve upon the host response mechanism in containing M. tb infection, our lab has previously shown that the addition of the biological antioxidant glutathione (GSH) has profound antimycobacterial effects. The aim of this study is to understand the additive effects of BCG vaccination and ex-vivo GSH enhancement in improving the immune responses against M. tb in both groups; specifically, their ability to mount an effective immune response against M. tb infection, maintain CD4+ and CD8+ T cells in the granulomas, their response to liposomal glutathione (L-GSH), with varying suboptimal levels of the first line antibiotics isoniazid (INH) and pyrazinamide (PZA), the expressions of programmed death receptor 1 (PD-1), and their ability to induce autophagy. Our results revealed that BCG vaccination, along with GSH enhancement, can prevent the loss of CD4+ and CD8+ T cells in the granulomas and improve the control of M. tb infection by decreasing the expressions of PD-1 and increasing autophagy and production of the cytokines interferon gamma IFN-γ and tumor necrosis factor-α (TNF-α).
NK Cells in the Treatment of Hematological Malignancies
Authors: Gonzalez-Rodriguez Ana P , Villa-Álvarez Mónica , Sordo-Bahamonde Christian , Lorenzo-Herrero Seila , Gonzalez Segundo
Published: September 2019

Natural killer (NK) cells have the innate ability to kill cancer cells, however, tumor cells may acquire the capability of evading the immune response, thereby leading to malignancies. Restoring or potentiation of this natural antitumor activity of NK cells has become a relevant therapeutic approach in cancer and, particularly, in hematological cancers. The use of tumor-specific antibodies that promote antibody-dependent cell-mediated cytotoxicity (ADCC) through the ligation of CD16 receptor on NK cells has become standard for many hematologic malignancies. Hematopoietic stem cell transplantation is another key therapeutic strategy that harnesses the alloreactivity of NK cells against cancer cells. This strategy may be refined by adoptive transfer of NK cells that may be previously expanded, activated, or redirected (chimeric antigen receptor (CAR)-NK cells) against cancer cells. The antitumor activity of NK cells can also be boosted by cytokines or immunostimulatory drugs such as lenalidomide or pomalidomide. Finally, targeting immunosubversive mechanisms developed by hematological cancers and, in particular, using antibodies that block NK cell inhibitory receptors and checkpoint proteins are novel promising therapeutic approaches in these malignant diseases.
Nanomechanical Properties of a Bicomponent Epoxy Resin via Blending with Polyaryletherketone
Authors: Hu Haixia , Liu Zhiwei , Wang Chengjun , Meng Limin , Shen Yuzhe
Published: September 2019

In order to investigate the nanomechanical behaviors and nanotribological properties of bicomponent epoxy resin (BE) blends, which were filled with thermoplastic polyaryletherketone (PAEK) powders, nanoindentation and nanoscratch tests were performed. The brittle fractured morphologies of bicomponent epoxy resin blends were studied. The microhardness and elastic modules of the materials were measured using the nanoindentation technology. The hardness, elastic modulus, and other mechanical properties of materials on a nanoscale were determined. Nanoindentation and scratch experiments showed that the indentation response is dominated by plastic deformation. The microhardness is the lowest as the content of PAEK powders is increased to 30 parts per hundred parts of resin (phr), while that of the neat bicomponent epoxy resin specimen is the highest. Furthermore, the pristine bicomponent epoxy resin (BE) exhibited better load-carrying and indentation recovery capacity than the other three samples. The nanoscratch results indicate that the frictional coefficient of the BE/PAEK-30 blend is the lowest, and while that of the pristine bicomponent epoxy resin is the highest, with better scratch/wear resistance.
Eccentric Training Interventions and Team Sport Athletes
Authors: McNeill Conor , Beaven C. Martyn , McMaster Daniel T. , Gill Nicholas
Published: September 2019

Eccentric resistance training has been shown to improve performance outcomes in a range of populations, making it a popular choice for practitioners. Evidence suggests that neuromuscular adaptations resulting from eccentric overload (EO) and accentuated eccentric loading (AEL) methods could benefit athletic populations competing in team sports. The purpose of this review was to determine the effects of eccentric resistance training on performance qualities in trained male team sport athletes. A systematic review was conducted using electronic databases PubMed, SPORTDiscus and Web of Science in May 2019. The literature search resulted in 1402 initial articles, with 14 included in the final analysis. Variables related to strength, speed, power and change of direction ability were extracted and effect sizes were calculated with a correction for small sample size. Trivial, moderate and large effect sizes were reported for strength (−0.17 to 1.67), speed (−0.08 to 1.06), power (0.27 to 1.63) and change of direction (0.48 to 1.46) outcomes. Eccentric resistance training appears to be an effective stimulus for developing neuromuscular qualities in trained male team sport athletes. However, the range of effect sizes, testing protocols and training interventions suggest that more research is needed to better implement this type of training in athletic populations.
Coastal Flooding and Inundation and Inland Flooding due to Downstream Blocking
Authors: Pietrafesa Leonard , Zhang Hongyuan , Bao Shaowu , Gayes Paul , Hallstrom Jason
Published: September 2019

Extreme atmospheric wind and precipitation events have created extensive multiscale coastal, inland, and upland flooding in United States (U.S.) coastal states over recent decades, some of which takes days to hours to develop, while others can take only several tens of minutes and inundate a large area within a short period of time, thus being laterally explosive. However, their existence has not yet been fully recognized, and the fluid dynamics and the wide spectrum of spatial and temporal scales of these types of events are not yet well understood nor have they been mathematically modeled. If present-day outlooks of more frequent and intense precipitation events in the future are accurate, these coastal, inland and upland flood events, such as those due to Hurricanes Joaquin (2015), Matthew (2016), Harvey (2017) and Irma (2017), will continue to increase in the future. However, the question arises as to whether there has been a well-documented example of this kind of coastal, inland and upland flooding in the past? In addition, if so, are any lessons learned for the future? The short answer is “no”. Fortunately, there are data from a pair of events, several decades ago—Hurricanes Dennis and Floyd in 1999—that we can turn to for guidance in how the nonlinear, multiscale fluid physics of these types of compound hazard events manifested in the past and what they portend for the future. It is of note that fifty-six lives were lost in coastal North Carolina alone from this pair of storms. In this study, the 1999 rapid coastal and inland flooding event attributed to those two consecutive hurricanes is documented and the series of physical processes and their mechanisms are analyzed. A diagnostic assessment using data and numerical models reveals the physical mechanisms of downstream blocking that occurred.
Comparison of Physical to Numerical Mixing with Different Tracer Advection Schemes in Estuarine Environments
Authors: Kalra Tarandeep S. , Li Xiangyu , Warner John C. , Geyer Wayne R. , Wu Hui
Published: September 2019

The numerical simulation of estuarine dynamics requires accurate prediction for the transport of tracers, such as temperature and salinity. During the simulation of these processes, all the numerical models introduce two kinds of tracer mixing: (1) by parameterizing the tracer eddy diffusivity through turbulence models leading to a source of physical mixing and (2) discretization of the tracer advection term that leads to numerical mixing. Physical and numerical mixing both vary with the choice of horizontal advection schemes, grid resolution, and time step. By simulating four idealized cases, this study compares the physical and numerical mixing for three different tracer advection schemes. Idealized domains only involving physical and numerical mixing are used to verify the implementation of mixing terms by equating them to total tracer variance. Among the three horizontal advection schemes, the scheme that causes the least numerical mixing while maintaining a sharp front also results in larger physical mixing. Instantaneous spatial comparison of mixing components shows that physical mixing is dominant in regions of large vertical gradients, while numerical mixing dominates at sharp fronts that contain large horizontal tracer gradients. In the case of estuaries, numerical mixing might locally dominate over physical mixing; however, the amount of volume integrated numerical mixing through the domain compared to integrated physical mixing remains relatively small for this particular modeling system.
The ‘Carbon Capture’ Metaphor: An English-Arabic Terminological Case Study
Authors: Haddad Haddad Amal , Montero-Martínez Silvia
Published: September 2019

The study of metaphorization processes in scientific texts is essential in terminological studies and the conceptual representation of specialized knowledge. It is considered to be a prolific tool in the creation of neologisms. Many cognitive models tried to study metaphorisation processes by drawing on metaphor and metonymy based on linguistic evidence. However, recent studies have highlighted the necessity of carrying out empirical tests in order to provide refined results that go beyond the traditional theories of conceptual metaphor and metonymy. This paper analyzes the underlying metaphor in the ‘carbon capture and sequestration’ event in both English and Arabic. It also discusses the influence of English, the lingua franca, in the transfer of the neologism ‘carbon capture and sequestration’, via translation processes, and its role in the so-called domain loss in the target language. Results were obtained through a corpus-based contrastive terminological analysis, extracted from specialized texts in English and Arabic in the subdomain of climate change. Data analysis was approached from the perspective of Frame-Based Terminology and Conceptual Complexes.
Best Proximity Results with Applications to Nonlinear Dynamical Systems
Authors: Al-Sulami Hamed H , Hussain Nawab , Ahmad Jamshaid
Published: September 2019

Best proximity point theorem furnishes sufficient conditions for the existence and computation of an approximate solution ω that is optimal in the sense that the error σ ( ω , J ω ) assumes the global minimum value σ ( θ , ϑ ) . The aim of this paper is to define the notion of Suzuki α - Θ -proximal multivalued contraction and prove the existence of best proximity points ω satisfying σ ( ω , J ω ) = σ ( θ , ϑ ) , where J is assumed to be continuous or the space M is regular. We derive some best proximity results on a metric space with graphs and ordered metric spaces as consequences. We also provide a non trivial example to support our main results. As applications of our main results, we discuss some variational inequality problems and dynamical programming problems.
Reduction of Bundles, Connection, Curvature, and Torsion of the Centered Planes Space at Normalization
Authors: Belova Olga
Published: September 2019

The space Π of centered m-planes is considered in projective space P n . A principal bundle is associated with the space Π and a group connection is given on the principal bundle. The connection is not uniquely induced at the normalization of the space Π . Semi-normalized spaces Π 1 , Π 2 and normalized space Π 1 , 2 are investigated. By virtue of the Cartan–Laptev method, the dynamics of changes of corresponding bundles, group connection objects, curvature and torsion of the connections are discovered at a transition from the space Π to the normalized space Π 1 , 2 .
Superring of Polynomials over a Hyperring
Authors: Ameri Reza , Eyvazi Mansour , Hoskova-Mayerova Sarka
Published: September 2019

A Krasner hyperring (for short, a hyperring) is a generalization of a ring such that the addition is multivalued and the multiplication is as usual single valued and satisfies the usual ring properties. One of the important subjects in the theory of hyperrings is the study of polynomials over a hyperring. Recently, polynomials over hyperrings have been studied by Davvaz and Musavi, and they proved that polynomials over a hyperring constitute an additive-multiplicative hyperring that is a hyperstructure in which both addition and multiplication are multivalued and multiplication is distributive with respect to the addition. In this paper, we first show that the polynomials over a hyperring is not an additive-multiplicative hyperring, since the multiplication is not distributive with respect to addition; then, we study hyperideals of polynomials, such as prime and maximal hyperideals and prove that every principal hyperideal generated by an irreducible polynomial is maximal and Hilbert’s basis theorem holds for polynomials over a hyperring.
Homotopy Approach for Integrodifferential Equations
Authors: Słota Damian , Hetmaniok Edyta , Wituła Roman , Gromysz Krzysztof , Trawiński Tomasz
Published: September 2019

In this paper, we present the application of the homotopy analysis method for solving integrodifferential equations. In this method, a series is created, the successive elements of which are determined by calculating the appropriate integral of the previous element. In this elaboration, we prove that, if this series is convergent, then its sum is the solution of the objective equation. We formulate and prove the sufficient condition of this convergence, and we give also the estimation of error of an approximate solution obtained by taking the partial sum of the considered series. Moreover, we present in this paper the example of using the investigated method for determining the vibrations of the freely supported reinforced concrete beam as well as for solving the equation of movement of the electromagnet jumper mechanical system.
On the High-Power Mean of the Generalized Gauss Sums and Kloosterman Sums
Authors: Liu Xinyu , Zhang Wenpeng
Published: September 2019

The main aim of this paper is to use the properties of the trigonometric sums and character sums, and the number of the solutions of several symmetry congruence equations to research the computational problem of a certain sixth power mean of the generalized Gauss sums and generalized Kloosterman sums, and to give two exact computational formulae for them.
Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis
Authors: Yu Mingyang , Zhang Rongguang , Ni Peng , Chen Shuaiyin , Duan Guangcai
Published: September 2019

Background and Objectives: To perform a systematic review and meta-analysis with the aim of determining the relationship between H. pylori infection and psoriasis. Methods: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. Results: The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of H. pylori infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15–2.52, P = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of H. pylori detection, a statistically significant increase of H. pylori infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of H. pylori infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42–3.63, I2 = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79–1.54, I2 = 0%). Conclusion: H. pylori infection is associated with psoriasis, and psoriasis patients with H. pylori infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices.
Chronic Obstructive Pulmonary Disease and the Optimal Timing of Lung Transplantation
Authors: Vazquez Guillamet Rodrigo
Published: September 2019

Chronic obstructive pulmonary disease (COPD) accounts for the largest proportion of respiratory deaths worldwide and was historically the leading indication for lung transplantation. The success of lung transplantation procedures is measured as survival benefit, calculated as survival with transplantation minus predicted survival without transplantation. In chronic obstructive pulmonary disease, it is difficult to show a clear and consistent survival benefit. Increasing knowledge of the risk factors, phenotypical heterogeneity, systemic manifestations, and their management helps improve our ability to select candidates and list those that will benefit the most from the procedure.
Pulmonary Embolism and Severe Asthma: Case Report and Literature Review
Authors: Lee Po-Hsin , Fu Pin-Kuei
Published: September 2019

Pulmonary embolism is a life-threatening disease. Its development is generally thought to be due to causes collectively known as the Virchow’s triad. Chronic inflammations are associated with the activation of coagulation and increased risks of venous thromboembolic events. Asthma is one of the chronic inflammatory diseases associated with procoagulants and antifibrinolytic activities in the airways. Coagulation is activated in patients with asthma with the following steps of pathophysiology: Increased tissue factor expression in various cell types, decreased activity of the anticoagulant protein C system and inhibition of fibrinolysis through over-production of plasminogen activator inhibitor type 1 (PAI-1). Asthma is therefore likely a risk factor for pulmonary embolism, especially in those patients with severe disease conditions together with frequent exacerbation. Here we present a case of severe asthma associated with coagulopathy and complicated by massive pulmonary embolism, presented with typical S1Q3T3 on electrocardiography (ECG) and massive thrombosis on computed tomography angiography, successfully treated with directed catheter thrombolytic therapy.
CT- and MRI-Based Assessment of Body Composition and Pancreatic Fibrosis Reveals High Incidence of Clinically Significant Metabolic Changes That Affect the Quality of Life and Treatment Outcomes of Patients with Chronic Pancreatitis and Pancreatic Cancer
Authors: Bieliuniene Edita , Brøndum Frøkjær Jens , Pockevicius Alius , Kemesiene Jurate , Lukosevicius Saulius , Basevicius Algidas , Atstupenaite Vaida , Barauskas Giedrius , Ignatavicius Povilas , Gulbinas Antanas , Dambrauskas Zilvinas
Published: September 2019

Background and Objectives: Both chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) may lead to cachexia, sarcopenia, and osteoporosis due to different mechanisms. Neither patient gender, age, nor body weight are good predictors of these metabolic changes having a significant negative impact on the quality of life (QOL) and treatment outcomes. The aim of this study was to evaluate radiological changes in body composition and to compare them with manifestations of exocrine and endocrine pancreatic insufficiency, body mass, and QOL among patients with CP and PDAC. Materials and Methods: Prospectively collected data of 100 patients with diagnosed CP or PDAC were used for analysis. All patients underwent dual-energy X-ray absorptiometry (DXA), computed tomography (CT), and magnetic resonance imaging (MRI). The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) was used to assess QOL. Diabetes and changes in fecal elastase-1 were also assessed. Results: There was no significant difference in skeletal muscle mass (SMM) among patients with CP and PDAC (p = 0.85). Significantly more underweight patients had low SMM (p = 0.002). Patients with CP had more pronounced pancreatic fibrosis (PF) (p < 0.001). Data showed a significant relationship between a high degree of PF and occurrence of diabetes (p = 0.006) and low fecal elastase-1 levels (p = 0.013). A statistically significant lower QOL was determined in patients with PF ≥ 50% and in the CP group. Conclusions: Sarcopenia and osteoporosis/osteopenia are highly prevalent among patients with chronic pancreatitis and pancreatic cancer, and CT- and MRI-based assessment of body composition and pancreatic fibrosis could be a potentially useful tool for routine detection of these significant metabolic changes.
Conventional and Complementary Medicine Health Care Practitioners’ Perspectives on Interprofessional Communication: A Qualitative Rapid Review
Authors: Nguyen Janet , Smith Lorraine , Hunter Jennifer , Harnett Joanna E.
Published: September 2019

Background and Objectives: People have multi-faceted health care needs and consult a diverse range of health care practitioners (HCP) from both the conventional and complementary medicine healthcare sectors. The effective communication between HCP and with patients are obvious requisites to coordinating multidisciplinary care and shared decision making. Further, miscommunication is a leading cause of patient harm and is associated with reduced patient satisfaction, health literacy, treatment compliance and quality of life. In conventional healthcare settings, the differences in professional hierarchy, training, communication styles and culture are recognised communication barriers. Less is known about interprofessional communication (IPC) that includes traditional and complementary medicine (TCM) HCP. This review aims to summarise the experiences and perceptions of conventional and complementary HCP and identify factors that influence IPC. Methods: A qualitative rapid literature review was conducted. Six databases were searched to identify original research and systematic reviews published since 2009 and in English. Excluded were articles reporting original research outside of Australia that did not include TCM-HCP, already cited in a systematic review, or of low quality with a score of less than three on a critical appraisal skills programme (CASP) checklist. A thematic analysis of included studies was used to identify and explore important and recurring themes. Results: From the conducted searches, 18 articles were included, 11 of which reported data on complementary HCP and seven were literature reviews. Four key themes were identified that impact IPC: medical dominance, clarity of HCP roles, a shared vision, and education and training. Conclusion: IPC within and between conventional and complementary HCP is impacted by interrelated factors. A diverse range of initiatives that facilitate interprofessional learning and collaboration are required to facilitate IPC and help overcome medical dominance and interprofessional cultural divides.
Oral Food Challenge
Authors: Calvani Mauro , Bianchi Annamaria , Reginelli Chiara , Peresso Martina , Testa Alessia
Published: September 2019

Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP).
Targeted Therapies and Immunotherapies in the Treatment of Esophageal Cancers
Authors: Barsouk Adam , Rawla Prashanth , Hadjinicolaou Andreas V. , Aluru John Sukumar , Barsouk Alexander
Published: September 2019

Esophageal cancer (EC) is among the most frequent and deadly cancers around the world. While esophageal adenocarcinoma (EAC) has one of the fastest-growing incidences amongst cancers in the US, it also has one of the lowest survival rates due to the limited effective treatment options. Fortunately, in the past decade, two targeted therapies and an immunotherapy agent have been approved by the FDA for metastatic EAC and esophageal squamous cell carcinoma (ESCC), with several more currently being considered for approval. In terms of immunotherapies, in July 2019, the FDA approved the PD1 inhibitor pembrolizumab for second-line treatment of PDL1-positive, advanced or metastatic ESCC. Two years before, pembrolizumab had been approved for the third-line treatment of PDL1-positive EAC. The PD1 inhibitor nivolumab, which was found in one study to outperform chemotherapy irrespective of PDL1 status, has yet to secure FDA approval. In terms of targeted therapies, although as many as 90% of EC cases show upregulated EGFR, anti-EGFR therapy has not been shown to improve survival. Ramucirumab, an antibody targeting both VEGF and HER2/neu receptors, has been approved for the treatment of refractory EAC, while the anti-HER2 monoclonal antibody (mAb) trastuzumab has been approved as front-line treatment for HER2-positive cases which account for approximately 20% of ECs. Although these targeted therapies and immunotherapies have resulted in significant improvements in survival for specific patient populations that are positive for certain biomarkers, such as PDL1 and HER2/neu, the survival rates remain low for a large proportion of the metastatic EC patient population, necessitating the development of further targeted treatment options.
The Fracture Behavior and Thermal Stability of Commercially Pure Nickel Sheets Processed by Constrained Groove Pressing
Authors: Wang Zongshen , Guan Yanjin , Li Lin , Zhu Lihua
Published: September 2019

Constrained groove pressing (CGP) is one of the most promising severe plastic deformation (SPD) techniques suitable for producing ultra-fine grained (UFG) sheet or plane metallic materials with unique physical, chemical, and mechanical properties. However, the heavily deformed sheets are usually with high strength but low ductility due to work hardening and micro-cracking, and the UFG microstructure and high strength are unstable especially when exposed to high temperatures. Thus, in this work, CGP was conducted on commercially pure nickel sheets and, firstly, the fracture mechanism of the processed sheets was examined. Then, the annealing behavior of CGP nickel sheets was investigated in detail to explore their thermal stability and improve their ductility. The results showed that significant grain refinement and strength improvement of the nickel sheets were achieved with great loss of ductility. The fracture surface morphology of the sheet sample exhibited typical characteristics of fatigue fracture, and inhomogeneous strain distribution and work hardening determined the micro-crack initiation position and propagation direction. The CGP sheets by one and two passes showed high thermal stability up to 650 and 600 °C, respectively, owing to different stored internal stresses and accumulated energy. In both cases, obvious recovery of elongation to failure from 12.7% and 10.6% to 29.3% and 27.3% were achieved by CGP with post-deformation annealing treatment, respectively, with acceptable drop of strength.
Numerical Modelling of the Influence of Argon Flow Rate and Slag Layer Height on Open-Eye Formation in a 150 Ton Steelmaking Ladle
Authors: Ramasetti Eshwar Kumar , Visuri Ville-Valtteri , Sulasalmi Petri , Fabritius Timo , Savolainen Jari , Li Mingming , Shao Lei
Published: September 2019

A transient computational fluid dynamics (CFD) modelling approach was used to study the complex multi-phase flow in an argon-stirred industrial scale ladle with a nominal capacity of 150 tons. During the stirring process, when gas was injected through the porous plug from the bottom into the steel bath, it breaks up into bubbles and infringes the slag layer creating an open-eye. The volume of fluid model was used to investigate the open-eye formation process in the simulations. In the numerical simulations, the open-eye area changed from 0.7 to 2.24 m2 with the increment of argon flow rate from 200 to 500 NL/min for slag layer thickness of 40 cm. Furthermore, the influence of slag layer height on the open-eye area was investigated. An argon flow rate of 200 NL/min was able to break the slag layer for slag layer height of 40 cm, and the open-eye formation was not possible for the same flow rate when the slag layer height was elevated from 40 to 55 cm. The numerical simulation results were validated against industrial measurements carried out at Outokumpu Stainless located in Tornio, Finland. The numerical simulation results of dynamics and time-averages of the slag area showed a good agreement when compared to the industrial measurements. To conclude, it is necessary to define gas flow rate based on the slag layer height to have an open-eye suitable for alloying.
Interaction between Microalloying Additions and Phase Transformation during Intercritical Deformation in Low Carbon Steels
Authors: Mayo Unai , Isasti Nerea , Rodriguez-Ibabe Jose M. , Uranga Pello
Published: September 2019

Heavy gauge line pipe and structural steel plate materials are often rolled in the two-phase region for strength reasons. However, strength and toughness show opposite trends, and the exact effect of each rolling process parameter remains unclear. Even though intercritical rolling has been widely studied, the specific mechanisms that act when different microalloying elements are added remain unclear. To investigate this further, laboratory thermomechanical simulations reproducing intercritical rolling conditions were performed in plain low carbon and NbV-microalloyed steels. Based on a previously developed procedure using electron backscattered diffraction (EBSD), the discretization between intercritically deformed ferrite and new ferrite grains formed after deformation was extended to microalloyed steels. The austenite conditioning before intercritical deformation in the Nb-bearing steel affects the balance of final precipitates by modifying the size distributions and origin of the Nb (C, N). This fact could modify the substructure in the intercritically deformed grains. A simple transformation model is proposed to predict average grain sizes under intercritical deformation conditions.
In Vivo Microdialysis of Endogenous and 13C-labeled TCA Metabolites in Rat Brain: Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia
Authors: Havelund Jesper F. , Nygaard Kevin H. , Nielsen Troels H. , Nordström Carl-Henrik , Poulsen Frantz R. , Færgeman Nils. J. , Forsse Axel , Gramsbergen Jan Bert
Published: September 2019

Cerebral micro-dialysis allows continuous sampling of extracellular metabolites, including glucose, lactate and pyruvate. Transient ischemic events cause a rapid drop in glucose and a rise in lactate levels. Following such events, the lactate/pyruvate (L/P) ratio may remain elevated for a prolonged period of time. In neurointensive care clinics, this ratio is considered a metabolic marker of ischemia and/or mitochondrial dysfunction. Here we propose a novel, sensitive microdialysis liquid chromatography-mass spectrometry (LC-MS) approach to monitor mitochondrial dysfunction in living brain using perfusion with 13C-labeled succinate and analysis of 13C-labeled tricarboxylic acid cycle (TCA) intermediates. This approach was evaluated in rat brain using malonate-perfusion (10–50 mM) and endothelin-1 (ET-1)-induced transient cerebral ischemia. In the malonate model, the expected changes upon inhibition of succinate dehydrogenase (SDH) were observed, i.e., an increase in endogenous succinate and decreases in fumaric acid and malic acid. The inhibition was further elaborated by incorporation of 13C into specific TCA intermediates from 13C-labeled succinate. In the ET-1 model, increases in non-labeled TCA metabolites (reflecting release of intracellular compounds) and decreases in 13C-labeled TCA metabolites (reflecting inhibition of de novo synthesis) were observed. The analysis of 13C incorporation provides further layers of information to identify metabolic disturbances in experimental models and neuro-intensive care patients.
Fabrication of an Efficient Planar Organic-Silicon Hybrid Solar Cell with a 150 nm Thick Film of PEDOT: PSS
Authors: Iqbal Sami , Su Dan , Yang Yi , Ullah Fahim , Zhou Huanli , Hussain Azam , Zhang Tong
Published: September 2019

Organic–inorganic hybrid solar cells composed of p-type conducting polymer poly (3,4-ethylene-dioxythiophene): polystyrenesulfonate (PEDOT: PSS) and n-type silicon (Si) have gained considerable interest in recent years. From this viewpoint, we present an efficient hybrid solar cell based on PEDOT: PSS and the planar Si substrate (1 0 0) with the simplest and cost-effective experimental procedures. We study and optimize the thickness of the PEDOT: PSS film to improve the overall performance of the device. We also study the effect of ethylene glycol (EG) by employing a different wt % as a solvent in the PEDOT: PSS to improve the device’s performance. Silver (Ag) was deposited by electron beam evaporation as the front and rear contacts for the solar cell device. The whole fabrication process was completed in less than three hours. A power conversion efficiency (PCE) of 5.1%, an open circuit voltage (Voc) of 598 mV, and a fill factor (FF) of 58% were achieved.
The Impact of Bioinformatics Pipelines on Microbiota Studies: Does the Analytical “Microscope” Affect the Biological Interpretation?
Authors: Siegwald Léa , Caboche Ségolène , Even Gaël , Viscogliosi Eric , Audebert Christophe , Chabé Magali
Published: September 2019

Targeted metagenomics is the solution of choice to reveal differential microbial profiles (defined by richness, diversity and composition) as part of case-control studies. It is well documented that each data processing step may have the potential to introduce bias in the results. However, selecting a bioinformatics pipeline to analyze high-throughput sequencing data from A to Z remains one of the critical considerations in a case-control microbiota study design. Consequently, the aim of this study was to assess whether the same biological conclusions regarding human gut microbiota composition and diversity could be reached using different bioinformatics pipelines. In this work, we considered four pipelines (mothur, QIIME, kraken and CLARK) with different versions and databases, and examined their impact on the outcome of metagenetic analysis of Ion Torrent 16S sequencing data. We re-analyzed a case-control study evaluating the impact of the colonization of the intestinal protozoa Blastocystis sp. on the human gut microbial profile. Although most pipelines reported the same trends in this case-control study, we demonstrated how the use of different pipelines affects the biological conclusions that can be drawn. Targeted metagenomics must therefore rather be considered as a profiling tool to obtain a broad sense of the variations of the microbiota, rather than an accurate identification tool.
Conferring the Metabolic Self-Sufficiency of the CAM Plasmid of Pseudomonas putida ATCC 17453: The Key Role of Putidaredoxin Reductase
Authors: Willetts Andrew
Published: September 2019

The relative importance of camphor (CAM) plasmid-coded putidaredoxin reductase (PdR) and the chromosome-coded flavin reductases Frp1, Frp2 and Fred for supplying reduced FMN (FNR) to the enantiocomplementary 2,5- and 3,6-diketocamphane monooxygenases (DKCMOs) that are essential for the growth of Pseudomonas putida ATCC 17453 on (rac)-camphor was examined. By undertaking studies in the time window prior to the induction of Fred, and selectively inhibiting Frp1 and 2 with Zn2+, it was confirmed that PdR could serve as the sole active supplier of FNR to the DKCMOs. This establishes for the first time that the CAM plasmid can function as an autonomous extrachromosomal genetic element able to express all the enzymes and redox factors necessary to ensure entry of the C10 bicyclic terpene into the central pathways of metabolism via isobutyryl-CoA.
Fatal Elephant Endotheliotropic Herpesvirus Infection of Two Young Asian Elephants
Authors: Pavulraj Selvaraj , Eschke Kathrin , Prahl Adriane , Flügger Michael , Trimpert Jakob , van den Doel Petra B. , Andreotti Sandro , Kaessmeyer Sabine , Osterrieder Nikolaus , Azab Walid
Published: September 2019

Elephant endotheliotropic herpesvirus (EEHV) can cause a devastating haemorrhagic disease in young Asian elephants worldwide. Here, we report the death of two young Asian elephants after suffering from acute haemorrhagic disease due to EEHV-1A infection. We detected widespread distribution of EEHV-1A in various organs and tissues of the infected elephants. Enveloped viral particles accumulated within and around cytoplasmic electron-dense bodies in hepatic endothelial cells were detected. Attempts to isolate the virus on different cell cultures showed limited virus replication; however, late viral protein expression was detected in infected cells. We further showed that glycoprotein B (gB) of EEHV-1A possesses a conserved cleavage site Arg-X-Lys/Arg-Arg that is targeted by the cellular protease furin, similar to other members of the Herpesviridae. We have determined the complete 180 kb genome sequence of EEHV-1A isolated from the liver by next-generation sequencing and de novo assembly. As virus isolation in vitro has been unsuccessful and limited information is available regarding the function of viral proteins, we have attempted to take the initial steps in the development of suitable cell culture system and virus characterization. In addition, the complete genome sequence of an EEHV-1A in Europe will facilitate future studies on the epidemiology and diagnosis of EEHV infection in elephants.