bluuebunny/crossref_metadata_2025 huggingface dataset:
Agripreneurial Success Among University Students: Perceived Barriers to Agricultural Entrepreneurship in India
Authors: Kumar Rohit , Bhat Anil , Magotra Ankit , Singh Kuldeep , Sharma Eva
Published: November 2024

The paper attempts to gauge the success of agripreneurs and seeks to explore the barriers which hinder the agripreneurial success among agricultural university students pursuing agriculture and allied education. This study proposes eight-dimension survey instrument called AgriSuccess scale for measuring the agripreneurial success. Responses from 300 students across various agricultural universities are analysed using SmartPLS. The study confirms the internal consistency and validity of the scales, with Cronbach's alpha values exceeding 0.7, indicating good reliability. The Fornell-Larcker criterion is met, ensuring adequate discriminant validity among constructs. This research adds to the literature on agricultural entrepreneurship by identifying specific barriers faced by aspiring agripreneurs and offering actionable recommendations for policymakers and educators.
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Authors: Janssens Sophie , Rennen Sofie , Bosteels Victor , De Nolf Clint , Lil Karo Van , Maréchal Sandra , Vetters Jessica , De Velde Evelien Van , Fayazpour Farzaneh , Roelandt Ria , Vandamme Niels , Verstaen Kevin , De Smedt Stefaan , Breckpot Karine , De Geest Bruno , Verbeke Rein , Lentacker Ine
Published: November 2024

Dendritic cells (DCs) are short-lived immune cells that continuously roam our body in search for foreign or self-antigens. Upon acquisition of antigen, they mature and start migrating to the lymph node to present the antigen to naïve T cells. Depending on the context wherein the antigen is acquired, DCs will mature in a homeostatic or immunogenic manner. So far, the field is lacking proper tools to distinguish between the two maturation states. Most maturation markers are shared between the two states and therefore inappropriate to use. Still, defining the proper maturation type is crucial as it determines how the DCs will instruct the T cells towards antigen expressing cells. In this study, we used a lipid nanoparticle (LNP)-based approach to steer DC maturation pathways in vivo. CITE-seq analysis allowed us to design a panel of flow cytometry markers that reliably annotates the two DC maturation states, as validated in an infection and in a tumor model. Furthermore, the data corroborated that uptake of empty LNPs in DCs induces their homeostatic maturation, in contrast to uptake of mRNA-LNPs or TLR ligand-adjuvanted LNPs, leading to distinct effector T cell outputs. This reveals that LNPs themselves are not being decoded as “danger” by cDC1s, and that the cargo is essential to provide adjuvants activity, which is highly relevant for targeted design of LNP-based therapies.
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Authors: Hameed Sakar Anwar , Ahmad Zrar Aziz Salih
Published: November 2024

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Petroleum complexes of metalloporphyrins and their dioxygen adducts
Authors: Aghahuseynova Minira , Vazirova Leyla
Published: November 2024

Porphyrin is the most studied tetrapyrrole-based compound. The cavity of porphyrin contains four pyrrolic nitrogen’s that are well suited to binding the majority of metal ions to form metalloporphyrin. The present work is devoted to the formation of petroleum-derived dioxygen and metalloporphyrin adducts in receptor compartments. Cyclodextrin is used as the receptor. It was determined that the oxidation reaction was selective and highly efficient, and that the clathrate compound was produced through noncovalent bonds. Cobalt, iron, nickel and manganese porphyrins have been shown to form dioxygen adducts with molecular oxygen. The structure and properties of dioxygen and metalloporphyrin adducts were studied for the first time. The dependence of the metalloporphyrin oxidation product yield on the number of receptors, reaction time, temperature, pressure, and nature of the solvent was studied. The above dependence shows that, unlike other metalloporphyrins, manganese-containing porphyrins are converted to dioxygen adducts with a high efficiency of 88 %. Based on experimental data, the equilibrium constant for the formation of dioxygen and petroleum metalloporphyrin adducts was calculated for the first time. It has been shown that the value of the equilibrium constant for the formation of adducts in the presence of the receptor exceeds the value of the equilibrium constant for oxygen reactions in the absence of the receptor by 4–5 points. In all metalloporphyrin complexes, a correlation in the formation of the peroxide structure of dioxygen adducts was established, which was confirmed by the presence in the IR spectrum of specific absorption bands characteristic of the fragment O2-2. Synthetic dioxygen adducts of metalloporphyrin compounds are of great interest because they transport synthetic oxygen.
Analysis of big safety attributes: from critical technical systems to individuals and communities
Authors: Yastrebenetsky Michael , Kharchenko Vyacheslav
Published: November 2024

This study aims to generalize conceptual provisions of Big Safety for individuals (persons) and communities (societies). This is necessary for developing a holistic approach to assessing and ensuring the safety of social and socio-technical systems. The investigative approach is straightforward, focusing on comparing the attributes of Big Safety for technical and social systems. It continues and develops ideas of comparativistics. The investigation involves: (a) generalizing safety (Big Safety) problem for new objects; (b) developing a centripetal tendency across various directions in safety science disciplines; the integration result is the formation of general concepts, theories, and the emergence of new interdisciplinary fields, which leads to an increase in the predictive level of scientific research; (c) using the experience of the most developed areas of safety work (for example, nuclear power plant safety) for other, seemingly disparate safety objects; (d) incorporating of some principles of cybernetics into Big Safety management; (e) discussing results of Big Safety attributes comparative analysis for technical systems, individuals and communities. The main contribution of this study is an improving methodology for comparing safety attributes between technical and social systems. The analysis of the ten key Big Safety attributes reveals many common opportunities to improve the safety and security components of due to the implementation through new technologies. On the other hand, both for technical systems and for individuals and communities, the use of new technologies is accompanied by the appearance of safety/security deficits that should be analyzed and tolerated
A trajetória da Revista Sergipana de Saúde Pública: um relato de experiência
Authors: Barroso Sheilla da Silva , Carvalho Daniele Castro , Travassos Daniele de Araújo
Published: November 2024

A Revista Sergipana de Saúde Pública (RSSP), ISSN 2965-4327 é um periódico científico criado pela Escola de Saúde Pública do Estado de Sergipe no âmbito da Fundação Estadual de Saúde (Funesa), teve sua primeira edição em 2022 e atualmente publica em fluxo contínuo. É um periódico de acesso aberto, disponível em formato eletrônico e sem custos para os autores, sendo os artigos submetidos a processo de revisão por pares (duplo cego). Ao longo desses 2 (dois) anos foram recebidos 82 artigos e destes 22 artigos foram publicados. O corpo editorial da RSSP conta com 58 avaliadores. A equipe editorial da revista participa de eventos na área de editoração cientifica, visando aprimorar a qualidade das publicações.
Retratações brasileiras no Retraction Watch Database
Authors: Damasio Edilson
Published: November 2024

Retratações de artigos científicos é o principal meio de comunicação de erros cometidos nas publicações científicas, que podem ser causados por más condutas ou não. Estudos indicam um aumento do número de retratações, e em 2023 teve um recorde de 10 mil retratações no mundo. A base de dados Retraction Watch disponibiliza informações sobre as retratações em periódicos. Foi realizado estudo quantitativo de 358 retratações de autores brasileiros no RWDB. Identificou-se que artigos foram publicadas em editoras tradicionais internacionais nas áreas Biomédicas. Existe um baixo número de retratações em revistas brasileiras. Os principais motivos/razões são, investigações dos editores, preocupações com Dados, duplicação de imagens. Erros em dados e/ou análises, seguem a tendência internacional de aumento.
Uso da inteligência artificial em publicações de periódicos brasileiros da área da saúde: análise cienciométrica
Authors: Paiva Dulciane Nunes , Felix Nathália Quaiatto , Martins Bruna Rezende , Machado Letiane de Souza , Krug Suzane Beatriz Frantz , Pelegrin Giuliana De
Published: November 2024

Estudo quantitativo de análise cienciométrica que analisou as normas de utilização da Inteligência Artificial (IA) para escrita científica em periódicos brasileiros da área da saúde. Foram identificados os 100 periódicos melhor qualificados no índice H, com Qualis superior ao extrato A4, em que 32 apresentavam orientações sobre o uso de IA em suas diretrizes. Nove periódicos (28,12%) forneciam recomendações acerca do uso das IA, 88,8% concordavam com o uso, 66,6% orientavam não listar a IA como autoria e, 55,5% mencionaram diretrizes internacionais. Foi evidenciado que alguns periódicos brasileiros estão atentos ao uso da IA nos manuscritos submetidos aos seus processos de avaliação, entretanto, a abordagem dessa temática em periódicos Qualis A em nível nacional ainda é limitada.
Núcleo de Publicação no Instituto Federal de Roraima: análise de resultados e aprendizados (2006-2024)
Authors: Oliveira Joelma Fernandes de , Ghedin Leila Marcia , Silva Silvana Menezes da
Published: November 2024

Resumo: Compreende-se que o registro do conhecimento científico de uma instituição acadêmica e pública se concretiza por meio de sua produção editorial. Neste sentido, os setores de publicação dessas instituições assumem um papel crucial de salvaguardas dessas informações. Portanto, este artigo tem por objetivo analisar as experiências do Núcleo de Publicação do IFRR, destacando os resultados alcançados e os aprendizados obtidos ao longo do período de 2006-2024. Além disso, busca-se a materialização do registro detalhado do que já aconteceu, de modo a servir como um guia para a compreensão de acontecimentos futuros. Para isso, foram utilizados como procedimentos metodológicos a pesquisa documental e a análise qualitativa do conteúdo dos documentos. Essas ações trouxeram à tona os obstáculos enfrentados pelo Núcleo no seu percurso e possibilitaram resgatar as boas práticas utilizadas para ultrapassá-los.
Four-quark scatterings in QCD II
Authors: Fu Wei-jie , Huang Chuang , Pawlowski Jan M. , Tan Yang-yang
Published: November 2024

In [SciPost Phys. 14, 069 (2023)], we initiated a program for the quantitative investigation of dynamical chiral symmetry breaking and resonant bound states in QCD with the functional renormalisation group, concentrating on the full infrared dynamics of four-quark scatterings. In the present work we extend this study and take into account a three-momentum channel approximation (s,t,us,t,u-channel) for the Fierz-complete four-quark vertices. We find that the four-quark vertex in this approximation is quantitatively reliable. In particular, we have computed the pion pole mass, pion decay constant, Bethe-Salpeter amplitudes, the quark mass function and wave function. Our results confirm previous findings that low energy effective theories only reproduce QCD quantitatively, if initiated with a relatively low ultraviolet cutoff scale of the order of 500 MeV. The quantitative description set up here paves the way for reliable quantitative access to the resonance structure in QCD within the fRG approach to QCD.
LHC EFT WG note: SMEFT predictions, event reweighting, and simulation
Authors: Belvedere Alberto , Bhattacharya Saptaparna , Boldrini Giacomo , Chatterjee Suman , Calandri Alessandro , Sánchez Cruz Sergio , Dickinson Jennet , Glessgen Franz Jacob , Goldouzian Reza , Grohsjean Alexander , Jeppe Laurids , Knight Charlotte , Mattelaer Olivier , Mohrman Kelci , Nelson Hannah , Perovic Vasilije , Presilla Matteo , Schoefbeck Robert , Smith Nick
Published: November 2024

This note provides a comprehensive overview of tools for predicting observables in the Standard Model effective field theory (SMEFT) at both tree level and one loop using event generators. We evaluate three primary methodologies–event reweighting, separate simulation of squared matrix elements, and full SMEFT process simulation–focusing on their statistical performance, computational efficiency, and potential biases. Each approach is assessed in terms of its accuracy, highlighting trade-offs between precision and resource demands. Practical insights into their applicability for high-energy physics analyses are offered, with particular attention to processes where SMEFT effects are significant. Additionally, we discuss the role of helicity in reweighting strategies and its impact on the quality of predictions. By comparing the methods across various LHC processes, this note provides guidance for selecting the most effective strategy for various SMEFT studies, ensuring robust predictions while optimizing computational resources.
Assistência de Enfermagem no Centro de Detenção na Cidade de Manaus: um Olhar ao Vínculo Materno de uma Mãe Encarcerada
Authors: Cruz Ane Jessica de Souza , Oliveira Marilza Assunção de
Published: November 2024

Descrever a atuação do enfermeiro na atenção com mulheres em sistema carcerário; identificar dificuldades dos enfermeiros na atenção pré-natal às encarceradas. Metodologia: revisão integrativa, os dados foram coletados nas bases dados LILACS, MEDLINE, biblioteca virtual SciELO e publicações no Ministério da Saúde e leis brasileiras. Foram selecionados 20 que após refinamento 15 atenderam aos critérios de inclusão. Resultados: O pré-natal é um direito de toda mulher, pórem quando a mesma está encarcerada, medos e desesperos podem aparecer, o profissional de enfermagem tende está à frente e habilitado para lhe dar a melhor assistência, já que a dificuldade de se manter um pré-natal é quase impossível devido suas condições de encarceramento. Conclusão: Embora exista uma politica pública para a gestante, no sistema carcerário ainda existe uma dificuldade em resguardo desta gravidez e o profissional de enfermagem procura prestar um atendimento eficiente e da melhor forma dentro de suas possibilidades.
COMPLICATIONS IN IMPLANT DENTISTRY
Authors:   Post Graduate Student, Department of Periodontology, Divya Jyoti College of Dental Sciences & Research, Ghaziabad, Uttar Pradesh, India., Kartikey Kumar , Sarkar Payal ,   Pediatric Dentist, MDS, Department of Pediatric& Preventive Dentistry, Divya Jyoti College of Dental Sciences & Research, Ghaziabad, Uttar Pradesh, India.
Published: November 2024

In dentistry, quest for newer techniques are never ending. One such newer technique is Dental Implant which has been introduced to obtain maximum benefits for good clinical performance.Dental implants made of titanium with threads are inserted into the bone during a surgical procedure.After a healing period, the implant is osseointegrated and ready for loading and function as a dental unit. Biological complications, such as biofilm-induced inflammatory bone loss, that affect osseo-integrated dental implants have become more prevalent with the increasing number of implant carriers, which is a challenge in clinical practice.Dental Implants is a promising technique for replacement of lost tooth structure, however it comes with some complications that can be overruled only when dentists have proper knowledge about it. Thus this article discuss about various complications associated with Dental Implants.
COMPREHENSIVE REVIEW OF POLYCYSTIC OVARIAN DISEASE: PATHOPHYSIOLOGY, DIAGNOSIS, AND EMERGING TREATMENT STRATEGIES
Authors: Meher Krishna
Published: November 2024

Polycystic Ovarian Infection (PCOD), consistently implied as Polycystic Ovary Condition (PCOS), is a confounding endocrine issue that influences conceptive created ladies all around the planet, adding to massive metabolic, regenerative, and mental difficulties. This survey gives an all out assessment of PCOD, zeroing in on its pathophysiology, interesting models, and current and arising treatment methodology. The pathophysiology of PCOD is multifactorial, including inborn, hormonal, and ordinary variables, close by advancing disclosures that feature the control of stomach dysbiosis, epigenetic changes, and possible safe structure parts. Finding keeps fixed on the Rotterdam standards, yet new interesting gadgets and biomarkers are being investigated to additionally foster accuracy and early disclosure. Current association ways of thinking feature way of life changes, pharmacological drugs like insulin sensitizers and enemies of androgens, and, in difficult cases, mindful mediations. Arising remedies, including nutraceuticals, engineered modulators, and huge level helped regenerative advances, give extra roads to changed and wide thought. Future heading in PCOD the bosses incorporate the limit of adjusted drug, preventive structures for high-risk people groups, and the need for went on with research on extraordinary biomarkers and steady systems. This study includes the significance of a perplexing, individualized treatment technique for overseeing work on clinical results and individual satisfaction for ladies impacted by PCOD.
PROTECTION FROM CARDIOVASCULAR DISEASES USING BETA-BLOCKERS: A LITERATURE REVIEW
Authors: Kuntal Kanika
Published: November 2024

The role of beta-blockers in cardiovascular protection has been a hot topic of research. Myocardial oxygen demand, heart rate, and blood pressure are all reduced as the action of epinephrine and norepinephrine on beta-adrenergic receptors is inhibited. In congenital heart disease people want from admission towards evaluating the hypertensive status with beta-blocker monitoring activity. Also, it looks at the adverse effects of beta blockers including bradycardia, tiredness and asthma attacks. The advantages and disadvantages of selective and non-selective beta-blockers are summarized based on clinical use and efficacy. Such relative benefits emphasize the need for individualization since the above strategies are aimed at augmenting the therapeutic actions of beta blockades impose a serious risk of side effects. Taken together, beta-blockers have been integral in the treatment of different cardiovascular pathologies leading to better health of patients.
HOSPITALIZATION TRENDS AND MORBIDITIES IN SICKLE CELL ANEMIA: A CENTRAL INDIA PERSPECTIVE
Authors:   Department of Physiology, Government Medical College, Chandrapur., Mutyalwar Piyush , Falke Bhalchandra ,   Department of Pediatrics, Government Medical College, Chandrapur., Tekade Avinash ,   Department of Physiology, Government Medical College, Chandrapur.
Published: November 2024

Background and Objective: Sickle cell anemia is a common genetic disorder characterized by recurrent crisis, complications, and significant morbidity, particularly in children. This study aimed to investigate the pattern, type, and frequency of crisis, systemic complications, and morbidity profile in hospitalized children with sickle cell disease (SCD) at Government Medical College and Hospital, Chandrapur.

Methods: A prospective study was conducted over a year, from November 2023 to October 2024, involving 133 hospitalized children aged 0-12 years diagnosed with SCD, including both previously and newly diagnosed cases through Hemoglobin Electrophoresis. The study collected data on hospitalization frequency, crisis types, systemic complications, and morbidity. Children were evaluated for symptoms, clinical findings, and laboratory parameters related to sickle cell crisis and organ failure.

Results: The most common presenting symptom was pain, observed in 53.94% of the children, with bone pain, abdominal pain, and joint pain being the predominant types. Fever seen in 45.18% and pallor in 26.75% were the next most frequent symptoms, followed by jaundice in 21.05% and respiratory complaints such as cough in 13.60% and breathlessness in 11.40% patients. The majority of hospitalizations were due to vaso-occlusive crisis as seen in 53.94%, followed by severe anemia in 35.52% and acute febrile illness in 43% of patients. Systemic complications included hepatomegaly (65.78%), splenomegaly (45.61%), and respiratory distress (8.33%). Acute chest syndrome (3.55%), hemolytic crisis (14.9%), and splenic sequestration crisis (5.70%) were also notable findings.

Conclusion: In children with sickle cell anemia, VOC, febrile illnesses, and severe anemia are the leading causes of morbidity and hospitalization. Bone and abdominal pain were common symptoms, frequently associated with fever. The study highlights the need for community-based screening, parental counseling, and antenatal interventions to reduce the burden of sickle cell disease in tribal populations.
Clinical case of a newborn with tuberous sclerosis
Authors: Gurevich N. L. , Cherkasova T. M. , Kazanina A. B. , Vidershpan K. D.
Published: November 2024

Bourneville-Pringle disease or tuberous sclerosis is a multisystem, genetically determined disease that manifests mainly in childhood and is manifested by the formation of benign neoplasms (hamartomas) in various organs and tissues. Tuberous sclerosis is a rare (orphan) disease. The prevalence of tuberous sclerosis among newborns ranges from 1:6000 to 1:10000. Tuberous sclerosis is inherited in an autosomal dominant manner. An analysis of a clinical case of a newborn child with tuberous sclerosis (Bourneville-Pringle disease) is presented. The peculiarity of the presented observation is the diagnosis of the disease during prenatal ultrasound screening in the third trimester with the identification of multiple space-occupying formations in the brain and heart of the fetus. Confirmation of the diagnosis in the early neonatal period is based on the presence of primary (major) diagnostic criteria: multiple cardiac rhabdomyomas, brain tubera and retinal hamartomas. The diagnosis was made primarily on the basis of data from echographic research methods, which have demonstrated their effectiveness in identifying typical signs of this disease in the perinatal period. Neonatologists should be wary of children with cardiac radbomyomas detected prenatally, due to the fact that this cardiac tumor is highly likely to be combined with tuberous sclerosis and is its diagnostic marker. In addition to heart damage, the early onset of the disease in the perinatal and postnatal periods manifests itself in damage to the central nervous system. Patients with tuberous sclerosis require lifelong monitoring from the first days of life by a multidisciplinary team of specialists with special attention to life-threatening complications (progressive hydrocephalus, status epilepticus, renal failure, respiratory failure). Managing a patient with this pathology is a complex multidisciplinary problem.
Cystitis of viral etiology in children from the point of view of a urologist
Authors: Nikitin S. S. , Guseva N. B. , Kononova S. A.
Published: November 2024

The development of Russian clinical guidelines for the treatment of children with recurrent urinary tract infection and cystitis was almost completed by 2019. But the high level of complications of viral and infectious nature during the coronavirus pandemic has made significant adjustments to the diagnostic and therapeutic complex of management of such patients. Clinical recommendations are presented for urinary tract infections in children, which include both cystitis and pyelonephritis. Exclusively for cystitis, there are only clinical recommendations “Cystitis in women”. Cystitis is classified according to various signs: etiology, course, primary lesion and complicated forms. In determining acute cystitis in clinical recommendations for urinary tract infection in children, the bacterial origin of inflammation is indicated. It is assumed that the most common causative agents of cystitis are E. coli and other representatives of the intestinal group. In the practice of a pediatric urologist, there are observations when patients with complaints characteristic of cystitis are treated against or after viral infections (respiratory viral, and in recent years, including against the background of a new coronavirus infection). At the same time, with a few exceptions, normal results of urine tests are revealed in patients, and in observations when the diagnostic process comes to cystoscopy, hyperemia and hyperplasia of the epithelium, not characteristic of the bacterial etiology of cystitis, is detected on the mucosa (usually in the lower part of the Lieto triangle and in the neck of the bladder). Taking into account the peculiarities of the structure of the bladder wall in children, we consider it important to understand the etiology of cystitis. The article describes the features of cystitis caused by various viruses: herpes simplex virus, cytomegalovirus, papillomavirus infection, polyomavirus and coronavirus. For the final revision of clinical recommendations for the treatment of children with cystitis and the prevention of complications from the upper urinary tract in bacterial, viral and other infectious diseases, the experience of urologists and surgeons should be analyzed.
Frequently ill children: A new vision of the old problem
Authors: Gritsinskaya V. L. , Novikova V. P.
Published: November 2024

The article is devoted to an urgent medical and social problem of recurrent respiratory infections in children. In domestic pediatric practice, there are currently no unified approaches to diagnosis, prophylactic medical examination and rehabilitation of a group of sickly children. This article presents an adapted version of the Inter-society Consensus developed by the Italian Medical Associations in the field of pediatrics, pediatric infectious diseases, allergology, immunology, and otorhinolaryngology. The consensus includes an algorithm of a differentiated approach to determining the risk of recurrent respiratory pathology in children in different age groups, markers for additional examination to exclude genetic pathology and chronic diseases. The low effectiveness of prevention of recurrent acute respiratory infections in children creates prerequisites for the search of methods to improve the rehabilitation potential of patients. Over the past few years, the study of the human gut microbiome as a separate extracorporeal organ that affects all body systems is promising. In the case of propensity to frequent respiratory diseases, the most important attention is paid to the “intestine-lung” axis, since this axis is bidirectional and represents the cross-relationships of the respiratory and digestive systems. The presence of this axis is due to the structural homology of the intestine and lungs from the point of view of histology and embryology and confirmed by experimental and clinical studies. The article presents the results of domestic and foreign studies devoted to find the changes in a gut microbiome and microbiome of upper respiratory tract. There is a numberof systematic reviews and meta-analyses demonstrating the presence of interrelated and interdependent changes in the gut microbiome duringrecurrent respiratory infection process, which allows to consider the prospect of using probiotics in sickly children.
Key aspects of choosing antipyretic therapy in pediatric practice
Authors: Zakirova A. M. , Moroz T. B. , Faizullina R. A. , Samorodnova E. A. , Shayapova D. T. , Salmanidina D. R. , Kadriev A. G. , Rashitova E. L. , Khairullina L. A. , Kadriev D. A.
Published: November 2024

Introduction. Currently, nonsteroidal anti-inflammatory drugs with anti-inflammatory, analgesic, and antipyretic effects are widely used in clinical practice.

Aim. To obtain additional data on the efficacy and safety of paracetamol and ibuprofen in children with acute respiratory infections accompanied by fever.

Materials and methods. A single-center (observational) study was conducted involving 32 children (5.2 ± 1.8 years) with fever due to acute respiratory disease. At temperatures above 38.5 °C, an antipyretic in the form of forte was prescribed in an age-specific dosage according to the instructions for a course of 3 days. Patients of the first group (n = 16) were prescribed paracetamol against the background of standard therapy for the underlying disease according to the nosology, children of the second group – ibuprofen forte in syrup without fragrances, dyes and flavor additives. The average daily temperature, frequency and duration of taking the study drugs, the development of adverse reactions, a score of satisfaction with parents/legal representatives of the use of antipyretics and quality of life were taken into account.

Results. The result of therapy was clinical improvement: normalization of temperature (below 37.2 °C) over time with analysis of average daily values after 1, 4 hours, 1, 2, 3 days. The patients of both groups did not need to take antipyretics after 10 hours in 47.1% of cases, after 18 hours – in 53.8%. Noted the absence of adverse drug and allergic reactions and drug rejection by children, which confirms their safety. The average satisfaction rating of parents/legal representatives was 4.87 ± 0.23 (96.2% rated the effects of the studied drugs as “satisfied” and “completely satisfied”). The quality of life improved significantly with normalization of temperature by the end of the 3 days (1.92 ± 0.07).

Discussion. The drugs ibuprofen and paracetamol are safe for use in pediatric practice if the dosage rules are followed and are approved for use by the World Health Organization, the FDA and other expert organizations. In addition, the emergence of new forms of release of these drugs is most important in pediatrics.

Conclusions. The study conducted allows us to state the effectiveness of paracetamol and ibuprofen in the form of tablets and forte without fragrances, dyes and flavors, when taken in the correct dosage, which resulted in the relief of fever against the background of acute respiratory infections and an improvement in the quality of life.
The effect of antiseptic solutions on the accuracy in blood glucose measurement using a personal glucose meter
Authors: Vitebskaya A. V. , Telegina K. P.
Published: November 2024

Introduction. Patients with diabetes mellitus perform blood glucose measurements daily using their personal glucose meters. The procedure of disinfecting the place of blood sampling with antiseptic solutions or washing hands with soap and drying them thoroughly is recommended to the patients to prevent infections. However, the effects of used antiseptics on the accuracy in blood glucose measurement using glucose meters have not been evaluated.

Aim. To evaluate the effects of antiseptic solutions on the accuracy in blood glucose measurement using a personal glucose meter. Materials and methods. We mixed several drops of the control solution (CS) with low “L” or high “H” concentrations, which were developed for the Contour Plus glucose meter, and a drop of one of five antiseptic solutions: chlorhexidine bigluconate (Chlorhexidine), benzyl dimethyl[3-(myristoylamine)-propyl] ammonium chloride monohydrate (Miramistin), salts of fatty acids (liquid soap), ethyl alcohol, hydrogen peroxide. Thereafter, the blood glucose levels were measured with a glucose meter. The results obtained were compared with the reference range for the CS with appropriate concentration.

Results. Chlorhexidine solution had no effect on the blood glucose measurements in the CS. Adding Miramistin solution (1/5 of the sample with CS “L” and “H”) and liquid soap (4/5 of the sample with CS “L” and 2/5 of the sample with CS “H”) resulted in underestimating blood glucose measurements. Alcohol solution had no effect on the blood glucose measurements in the CS “L”, but the glucometer failed to measure the blood glucose concentration in half of the cases, requiring the test strip to be replaced (“E11” error); when mixed with CS “H”, the measurements were overestimated in 2/5 of samples. Adding hydrogen peroxide solution (4/5 of the sample with CR “L” and “H”) resulted in overestimating the blood glucose measurements.

Discussion. Getting fruit juice on the hands, applying hydroquinone-containing cosmetics to the skin affects the accuracy in glucose measurements. Correct use of alcohol-containing disinfectants does not affect results of the blood glucose measurement using a personal glucose meter.

Conclusion. The results of the blood glucose measurement using a glucose meter can be significantly distorted if antiseptic gets into the sample. Traces of antiseptic should be removed before obtaining the sample that will be used to measure the blood glucose level with a glucose meter. Hydrogen peroxide should not be used as antiseptic solution when using a glucose meter.
Hypovitaminosis D: Clinical discussions and new International Endocrine Society guidelines (Endocrine Society recommendations)
Authors: Taranushenko T. E. , Zakharova I. N.
Published: November 2024

The article presents current information on vitamin D. It considers not only well-known recommendations for the administration of vitamin D in paediatric practice, but also the clinical aspects of the new guidelines – Vitamin D for disease prevention: a clinical practice guideline of the Endocrine Society 2024. The document was created using the results of the review of prioritized randomized placebo-controlled trials in general populations, taking into account systematic reviews of electronic databases of patients and their representatives (without an established indication for vitamin D treatment or 25[OH]D testing). The work assessed the effect of “empirical supplementation” defined as vitamin D intake at a dose that exceeds the Dietary Reference Intakes (DRI). This article considers two sections of above guidelines (obstetric and paediatric), alongside with the results of the analytical review, which present some scientific interest, deserve the attention of practicing physicians, confirm the importance of prevention in childhood, as well as indicate the need for further studies on the assessment of vitamin D status using long-term follow-ups and a personalized approach to the groups of children and adolescents that exact very careful attention. Apart from the new guidelines, attention is drawn to the urgency of the Russian National Program for Vitamin D Deficiency in Children and Adolescents of the Russian Federation: Modern Approaches to the Management, which outlines current treatment and preventive strategies for managing vitamin D deficiency in our country using the results of the multicenter study. It is important that Russian paediatricians have an evidence-based, specific and structured document with a brief look at the main strategic issues and operational decisions on the treatment and prevention of vitamin D hypovitaminosis in contrast to ongoing discussions in different countries of the world.
Modern presentation about the properties and nutritional value of fermented milk products and their use in children’s nutrition
Authors: Pyrieva E. A. , Safronova A. I. , Georgieva O. V. , Skvortsova V. A.
Published: November 2024

The article provides an overview of the current knowledge on the use of fermented milk products (FMPs) in the children’s nutrition and FMP contribution to the health and development of children. The benefits of FMPs due to the fermentation process underlying their production are considered. The article presents the findings of clinical studies emphasizing the favourable properties of FMP, including gut microbiota modulation, as well as immunostimulating, antibacterial, anticancer, antiallergenic and antioxidant effects; the outcomes of prospective cohort studies that identified a reverse association between the consumption of milk products in early childhood and blood pressure values in adolescence. The assortment of liquid FMP and drinks taking into account the regional nutritional characteristics of the population is described. A differentiated approach to defining the FMP type according to the milk raw materials, the starter composition, and the functional components is presented. The current FMP types produced using various starter cultures (lactic acid bacteria, yeast, acetic acid bacteria) and various fermentation methods that largely affect their taste and nutritional value are characterized. The distinctive features of probiotic FMPs are shown. Special mention is made of FMPs that are considered traditional for the Russian Federation, in particular kefir, which has a probiotic potential due to the composition of bacteria. The main methods used to produce FMPs, the biochemical processes during fermentation of products, their characteristics according to the starter cultures and the type of fermentation are described. The processing flow-charts for the liquid non-adapted curdled milk products and special requirements for the production of specialized FMPs for baby nutrition are considered. National guidelines for the introduction of FMPs to infant nutrition are discussed.
Efficacy of bioregulatory therapy for acute respiratory infections in children
Authors: Malanicheva T. G. , Ziatdinova N. V. , Ashrafullina Ch. I.
Published: November 2024

Introduction. Currently, much attention is paid to biregulatory therapy in the treatment of ARI, the goal of which is to improve the outcome of treatment by maintaining the body’s ability to autoregulate.

Aim. To study the effectiveness and safety of bioregulatory therapy using the multicomponent homeopathic drug in children with acute respiratory infections.

Materials and methods. 42 children with acute respiratory infections from 3 months to 7 years were examined. Main group: 22 children receiving, as part of complex therapy, the multicomponent homeopathic drug in the form of rectal suppositories as an antipyretic and anti-inflammatory agent. Comparison group: 20 children receiving the antipyretic and anti-inflammatory drug paracetamol. All patients were prescribed symptomatic therapy, which did not differ in the compared groups.

Results. It was revealed that the administration of the multicomponent homeopathic drug leads to a more rapid decrease in temperature (in the main group 1.70 ± 0.14 day; in the comparison group – 3.78 ± 0.17 day, p < 0.05) against the background of the disappearance of myalgia, headache, relief of symptoms of discomfort and intoxication, as well as manifestations of the local inflammatory process (sore throat, hyperemia of the pharynx, nasal congestion, rhinorrhea, cough), which led to a reduction in the duration of the disease by 3.4 days and reducing the need for antibiotics by 3.3 times. No side effects from the use of the multicomponent homeopathic drug were identified.

Discussion. The results of the study are comparable with the literature data. Thus, foreign authors have shown that the drug multicomponent homeopathic drug meets all the requirements for effective, but at the same time practically risk-free therapy for febrile anxiety, influenza infections, and pain.

Conclusions. The prescription of the multicomponent homeopathic drug as part of the complex therapy of ARI in children leads to faster relief of all symptoms and a reduction in the duration of the disease than with the use of paracetamol, with a better safety profile.
Modern approaches to the prevention of frequent respiratory infections in childhood
Authors: Melnikova I. M. , Mizernitskiy Yu. I.
Published: November 2024

In recent decades, there has been significant progress in the diagnosis, prevention and treatment of acute respiratory viral infections (ARVI), including influenza. The authors summarized the current literature data regarding the clinical effectiveness of the antiviral and immunomodulatory drug inosine pranobex in the prevention and treatment of frequent recurrent respiratory infections in children. The results of recent studies have shown that during the COVID-19 pandemic, non-drug restrictive measures influenced the typical seasonal patterns of circulation of various respiratory viruses and bacteria. Continuous monitoring of these viruses is necessary to take preventive measures and improve forecasting, in particular, to optimize the use of antiviral drugs, especially among children with frequent episodes of SARS, as well as those at risk of their severe course. Resistance to pathogens can be achieved by specific vaccination (against influenza, pertussis, pneumococcal, hemophilic infection, etc.), the introduction of immunoglobulins, monoclonal antibodies (for the prevention of respiratory syncytial virus (RSV) infection). However, the specific prevention of highly pathogenic and highly virulent viral infections (influenza, SARS-CoV-2) has its limitations due to the high variability of these viruses. Therefore, the focus of therapeutic and preventive measures against ARVI is increasingly shifting towards non-specific prevention based on the use of safe and effective antiviral drugs, drugs that can prevent the development of the disease and at the same time affect its course, ensuring a favorable outcome. One of the drugs of choice in the prevention and treatment of ARI is inosine pranobex, especially in children with a burdened premorbid background and in cases where a complex antiviral and immunomodulatory action is required. In the absence of the effect of preventive measures for 3 months, an in-depth examination of the child in a polyclinic or hospital and an individual selection of appropriate treatment are shown.
Panorama das Matrículas na Educação Infantil em Tempo Integral (2007 A 2017): Uma Análise do Contexto Brasileiro
Authors: Araújo Vania Carvalho de , Taquini Rennati , Auer Franceila , Neves Kalinca Costa Pinto das
Published: November 2024

Este artigo objetiva apresentar um panorama das matrículas na educação infantil em tempo integral de âmbito nacional, na série histórica do decênio 2007-2017. Realiza uma análise descritiva e explicativa de dados do Inep (Censo Escolar de 2007 a 2017) e do IBGE (estimativa de projeção populacional de 2017). Os resultados indicam tendência de crescimento das matrículas no tempo integral, sobretudo nas creches públicas municipais urbanas, com maior evolução que no tempo parcial. Constata predominância nas matrículas de crianças brancas dos sexos feminino e masculino de maneira similar.
Educação e ciclos políticos, em Portugal –
Authors: Cabrito Belmiro , Cerdeira Luísa , Mucharreira Pedro Ribeiro
Published: November 2024

O papel do ensino superior no desenvolvimento, exige políticas públicas educativas que impactam nos indivíduos e na sociedade. Neste artigo, analisa-se a evolução da procura de ensino superior, no período 2000-2020 em Portugal, à luz de políticas públicas conduzidas em contextos diferentes: períodos de crescimento económico e de austeridade; períodos de governação de centro-direita e de centro-esquerda, a fim de perceber se existe ligação entre a procura de educação e o enquadramento político do governo aceitando-se a hipótese de que a procura varia consoante o espectro político do governo.
A Reorganização do Trabalho Docente na Educação Superior no Contexto da Pandemia de Covid-19
Authors: Melo Savana Diniz Gomes , Sousa Joceli de Fátima Arruda , Vale Andréa Araujo do
Published: November 2024

O artigo problematiza o trabalho docente na educação superior no Brasil, a partir da sua reorganização no período da pandemia de COVID-19. É fundado em pesquisa bibliográfica e documental. Utiliza fontes secundárias, como artigos, documentos dos sindicatos patronais, material jornalístico sindical, etc. Como resultado, identifica tendências e confirma a premissa de que a pandemia é operada - seguindo a Doutrina do Choque - como oportunidade para a expansão da educação a distância nos setores público e privado e avançou nas consequências lesivas para o trabalho e para a saúde dos docentes.
As interfaces da relação público-privada na Formação de Professores/as: A BNCC e o lugar das universidades na Região Norte do Brasil
Authors: Andrade Antonia Costa , Costa Maria da Conceição dos Santos , Figueirêdo Arthane Menezes , Cabral Maria da Conceição Rosa
Published: November 2024

Esta pesquisa objetivou analisar as interfaces da relação público-privado com a execução de políticas de formação docente, em particular na implementação da BNCC na Região Norte do Brasil. Trata-se de um estudo documental com base em Fairclough (2010), pautado no Materialismo Histórico e Dialético. Os resultados apontam o aparelhamento e influências das instituições privadas, fortalecendo a mercantilização da formação docente, com reduzida presença das universidades.
CLIMATE CHANGE AND THE ROLE OF UNIVERSITIES
Authors: Hage Salomão Mufarrej , Castagna Molina Mônica , McCowan Tristan
Published: November 2024

This article provides a critical reflection on climate change in contemporary times, addressing the responses made by universities through land-based teacher education courses with a agroecology approach. It draws on historical dialectical materialism, with reference to land-based higher education and the Transforming Universities for a Changing Climate project. Significant possibilities are identified for the critical development of educators with an understanding of agroecology linked to the material production of life in the farming territories.
Expansão do Acesso, por Modalidade de Cursos, a Partir de uma Perspectiva Georreferenciada
Authors: Castelo Branco Uyguaciara Veloso , Jezine Edineide
Published: November 2024

O artigo objetiva analisar a expansão do acesso, por modalidade (Bacharelado e Licenciatura) e região geográfica, em cursos presenciais de universidades públicas federias, pós-Reuni. A pesquisa adota abordagem qualitativa, do tipo exploratória e analítica, apoiada em dados quantitativos, coletados das Sinopses Estatística do Censo da Educação Superior (MEC/INEP), discutidos a partir da categoria prestígio social (BOURDIEU, 2011; 2015). Os resultados mostram discrepâncias regionais, com decréscimo na oferta e matrículas em cursos de Licenciatura e crescimento nos Bacharelados.
A Financeirização da Economia: uma introdução
Authors: Oliveira Romualdo Luiz Portela de
Published: November 2024

Ante o crescente uso do termo “financeirização” para interpretar as modificações em curso na economia capitalista e seu uso na produção acadêmica sobre educação no Brasil, o presente artigo busca recuperar suas origens históricas e a forma como tem sido organizada a já abundante produção presente na literatura. Tomou-se como ponto de partida alguns trabalhos amplamente citados na literatura e revisões de literatura de modo a recuperar suas origens e os principais sentidos atribuídos ao termo. Conclui-se que há lacunas importantes na bibliografia, o que aponta para a necessidade de novas abordagens de modo a articular os diferentes conceitos utilizados para interpretar as transformações em curso, quer seja a relação entre financeirização, globalização e neoliberalismo, quer seja sua relação com a digitalização do capitalismo. Ao final, apresenta algumas questões que podem indicar possíveis linhas de investigação.