bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pemberdayaan dan Kesejahteraan Keluarga terhadap Capacity building Perempuan di Kecamatan Gemolong Kabupaten Sragen
Authors: Cahyaningsih Nita Nur , Kuswardinah Asih
Published: November 2022

Organisasi PKK dipelopori oleh perempuan sebagai penggeraknya, tujuannya untuk memberdayakan perempuan, pemberdayaan tidak tercapai apabila tidak ada capacity building sehingga perlu adanya capacity building perempuan, sesuai dengan tujuan penelitian untuk mengetahui pengaruh 10 program kerja PKK terhadap capacity building perempuan di Kecamatan Gemolong Kabupaten Sragen. Subyek penelitian anggota PKK Kecamatan Gemolong, populasi 349 anggota PKK dan sampel 25% dari populasi yaitu 88 responden dengan teknik pengambilan sampel proporsional random sampling, pengumpulan data melalui wawancara, dokumentasi, dan kuesioner dengan teknik analisis regresi berganda. Hasil penelitian secara simultan 10 program kerja TP PKK berpengaruh terhadap capacity building sebesar 69,1%, secara parsial 7 program kerja PKK tidak berpengaruh terhadap capacity building yaitu penghayatan pengamalan pancasila 0,14%, gotong royong 1,90%, pangan 1,48%, sandang 1,93%, perumahan tatalaksana rumah 0,81%, kesehatan 0,42%, kelestarian lingkungan hidup 2,99%, sedangkan 3 program kerja berpengaruh tergadap capacity building yaitu pendidikan keterampilan 12,46%, pengembangan kehidupan berkoperasi 6,10%, perencanaan sehat 15,13%. Saran yang dapat diberikan yaitu menjaga eksistensi PKK, meningkatkan program kerja PKK, dan penelitian selanjutnya menggunakan metode yang dapat menggali lebih dalam mengenai 10 program kerja PKK.
Eksperimen Pembuatan Chiffon Cake Substitusi Tepung Kulit Buah Naga Merah (Hylocereus Polyrhizus) pada Kesukaan Masyarakat, Kandungan Vitamin C, dan Flavonoid
Authors: Bimo Bimo , Saptariana Saptariana , Rosidah Rosidah , Wahyuningsih Wahyuningsih
Published: November 2022

Dalam penelitian ini, kulit buah naga akan dijadikan tepung dan disubstitusikan kedalam adonan chiffon cakesebagai bentuk diversifikasi produk berbahan dasar tepung terigu dan upaya pemanfaatan limbah dari kulit buah naga..Dengan pensubstitusian tepung kulit buah naga merah, diharapkan akan menambah nilai gizi pada chiffon cake nantinya. Tujuan dalam penelitian ini antara lain (1) mengetahui kesukaan masyarakat, dan (2) mengetahui kandungan gizi berupa vitamin C dan flavonoid pada chiffon cake tepung kulit buah naga merah.Teknik analisis data untuk uji kesukaan menggunakan metode analisis deskriptif, sedangkan uji kandungan gizi menggunakan metode titrasi langsung untuk vitamin C dan spektrofotometri UV-Vis untuk flavonoid.Objek penelitian ini adalah chiffon cake yang disubstitusikan dengan tepung kulit buah naga merah dengan persentase 6%, 10%, dan 14% dari tepung terigu yang digunakan sebanyak 75g. Hasil penelitian menunjukkan, terdapat perbedaan pada aspek warna, rasa dan tekstur chiffon cake tepung kulit buah naga merah dari masing-masing objek penelitian.Berdasarkan hasil uji kesukaan, sampel 286 (6%) menjadi sampel yang paling disukai dan memperoleh skor tertinggi dari aspek warna, aroma, rasa dan tekstur. Pada aspek warna diperoleh total skor sebesar 80.25%, pada aspek aroma diperoleh total skor sebesar 77.75%, pada aspek rasa diperoleh total skor sebesar 81.5%, dan pada aspek tekstur diperoleh total skor sebesar 81.75%. Sedangkan hasil dari analisis kandungan gizi, sampel 985 (14%) mendapatkan hasil tertinggi pada kandugan vitamin C dan flavonoid. Pada kandungan vitamin C diperoleh hasil sebesar 5,28mg dan pada flavonoid diperoleh hasil sebesar 26.5 mgQE.
Estudio del contenido materia orgánica por dos métodos analíticos en suelos de Honduras
Authors: Arévalo Gloria Elizabeth , Sánchez-Amaya José Moisés , Guillen-Marquina Ingrid
Published: November 2022

[Introduction]: The most common method to determine the organic matter content of soil is the "Walkley-Black" method, but this method has environmental disadvantages due to the use of the toxic potassium dichromate. As an alternative, the loss on ignition method arises. Both present significantly different results because the ignition method can report higher data due to the presence of clays and because it considers all the organic content of the sample, unlike Walkley-Black method, which considers only the compounds with longer chains. [Objective]: The relationship between the organic matter content determined by Walkley-Black and loss on ignition was determined considering the clay content. [Methodology]: 60 soil samples from northeastern and central Honduras were studied. The clay content was determined through the Bouyoucos method. The organic matter content was determined by the Walkley-Black method and by the ignition method following the guidelines by the international standards AASHTO T 194-97 (2018) and AASHTO T 267-86 (2013), respectively. [Results]: A valid linear relationship was found between the organic matter content determined by Walkley-Black and the loss on ignition regardless of the clay content. It was possible to establish an interpretation range for organic matter content for the loss on ignition method from the typical interpretation ranges reported for Walkley-Black organic matter content. [Conclusions]: The results of this study showed that it is possible to use the ignition method as an alternative to Walkley-Black.
Central Asian pages of the biography of metropolitan Arseny (Stadnitsky): 1924–1936
Authors: Ozmitel Ekaterina
Published: November 2022

The article reconstructs the last period of the life of the outstanding bishop of the Russian Orthodox Church Arseny (Stadnitsky). As Metropolitan of Novgorod, he was sent into exile in Central Asia, where he eventually spent 12 years. The data found in the letters of Metropolitan Arseny to the lawyer A.F. Koni and in the writings of Bishop Andrei (Ukhtomsky), for the first time made it possible to determine the dates and places of residence of Metropolitan Arseny in Central Asia: he lived in Krasnovodsk from mid-1924 until the summer of 1925; in Poltoratsk (Ashgabat) – from August 28, 1925 until the spring of 1927, and then in Tashkent.There was a change in the course of church policy pursued by the Deputy Patriarchal Locum Tenens Metropolitan Sergius (Stargorodsky) in 1927. The attitude of Metropolitan Arseny to the new church policy was ambiguous. There are diametrically opposite opinions in the writings of church historians on this subject, therefore, it seemed important to determine the church-political views of Metropolitan Arseny on the basis of analysis of a large body of narrative sources (letters and memoirs). At first, this attitude was sharply negative. He did not break off communication with Metropolitan Sergius, did not criticize him publicly, but he fell into disgrace and was left in exile after its end. In 1933, Metropolitan Arseny, having accepted the appointment to the Turkestan department, returned to episcopal ministry and church administrative activities. He visited Moscow at least three times to participate in the sessions of the Provisional Patriarchal Synod. During this period, Metropolitan Arseny also had a negative attitude towards some actions of the highest church authorities, in particular, measures to exalt Metropolitan Sergius. Metropolitan Arseny did not hide this, but he did not publicly denounce anyone, fearing to strengthen the schism.The article makes a number of assumptions concerning the role played by the figure of Metropolitan Arseny in the question of the succession of the supreme church authority and in the plans of the OGPU, which sought the liquidation of the Russian Church. These hypotheses require further study on the basis of new documentary sources.
Lithuanian priegaidė: a syllable or a word feature?
Authors: Andronov Aleksey
Published: November 2022

The place of priegaidė ‘syllable intonation’ in the phonological system of Lithuanian remains uncertain; so does its typological peculiarity. The article aims to discover the specific nature of this phonological feature taking into consideration the opposition between phonemic (inflectional) and syllabemic (isolating) language types. Phonetically similar prosodic means in these languages show noticeable functional differences determined by the structure of the meaningful units they belong to. Inflectional languages develop a system of suprasegmental phonological features, which integrate parts of their normally composite units, whereas isolating languages usually do with monosyllabic words (naturally, without stress) and monolithic morphemes with tones as distinctive features. Standard Lithuanian has priegaidė only on the stressed syllables, therefore its system can be called polyaccentual (not polytonic), i. e. possessing several types of accent. The dialects, however, show examples of relevant priegaidė besides syllables with primary stress. In this, more general, system priegaidė functions as a suprasegmental feature of a morpheme (exposed to fading in weak positions). The traditional differentiation of syllables according to priegaidė is secondary: a syllable provides conditions for the realization of priegaidė, but being part of the plane of expression, not connected with meaning, the syllable itself does not need differentiation.
POLARIZACIÓN EN EL MERCADO LABORAL Y AUSENCIA DE TRABAJO DECENTE PARA JÓVENES EN COLOMBIA
Authors: Calle Espinosa Yhelin Cristina
Published: November 2022

Este artículo pretende un acercamiento al fenómeno de polarización del ingreso laboral, considerando el tipo de contrato y la estabilidad laboral, para representar las condiciones de trabajo a las que se enfrentan los jóvenes entre los 16 y 25 años en Colombia. Para conseguir este objetivo, se presenta una revisión de informes sobre condiciones laborales actuales, se expone el concepto de polarización, y se prosigue a realizar un análisis clúster, donde se concluye que los jóvenes en el rango de edad 16-25 reciben en promedio una paga inferior por hora trabajada, y su situación es aún más grave si no poseen un contrato escrito o llevan menos de doce meses laborando en el mismo sitio.
CICLO ECONÓMICO Y MORA LEGAL EN EL SISTEMA FINANCIERO COSTARRICENSE
Authors: Chacón Marlon Yong , Soto Jiménez Max Alberto
Published: November 2022

Este artículo analiza el comportamiento de la mora del sistema financiero costarricense durante el periodo 1999-2010, en particular, de los bancos estatales y privados en el periodo reciente de la crisis económica internacional. Para hacerlo, se utilizan modelos económicos para investigar las relaciones de causalidad entre la mora, el ciclo económico real y el financiero. Se concluye que la calidad de la cartera de crédito del sector financiero de Costa Rica se relaciona con el nivel de actividad económica y con el ciclo real y financiero y que, aun cuando el efecto de la reciente crisis fue similar en bancos estatales y privados, estos últimos adoptan más rápido medidas que reducen la mora contable.
Making bodies and worlds
Authors: Knauss Stefanie
Published: November 2022

Inspired by the intense affective experience of watching the film 120 BPM (Beats Per Minute/Battements par minute) (Robin Campillo, 2017) about the HIV/AIDS activist group ACT UP Paris, I turn to affect theory to better understand how the film did what it did, tracing the circulating emotions of joy, anger, love, sadness, frustration, and exhilaration among the protagonists on screen, between the screen and the audience, and among the audience. I argue that the film’s affective economy has a religious quality in the way it creates bodies, worlds, and communities, and more specifically, that these religious sensibilities resonate with Christian affectivities in all their complexity. Thus, my argument about the religious affects of 120 BPM also contributes to the reflection on the affective dimensions of Christianity, and religion more broadly, and on the religious dimensions of affective-embodied aesthetic experiences.
Features of the cytokine profile in adolescents with microvascular complications of type 1 diabetes mellitus
Authors: Levkovich M. A. , Galkina G. A. , Voropai A. A. , Komkova M. V. , Morozova N. V. , Kravchenko L. V. , Krukier I. I. , Andreeva V. O. , Pogorelova T. N.
Published: November 2022

Despite advances of modern medical science, the consequences associated with management of complications in type 1 diabetes mellitus (DM1) in children and adolescents represent a serious problem. Common development of microvascular diabetic complications (retinopathy, neuropathy, kidney damage) still remains a sufficient obstacle for achieving high quality of life and social adaptation in the young patients, thus promoting studies of immune mechanisms involved in genesis of microvasculature damage under the conditions of dysmetabolic abnormalities associated with DM1. Our goal was to assess the role of altered cytokine balance in blood serum in development of microangiopathies in adolescents with DM1.

140 adolescent patients with type 1 diabetes aged 14-18 years were examined being divided in 2 groups: group I included the patients with glycated hemoglobin (HbA1c) level of > 9.0% (n = 65), and group II which included adolescents with HbA1C level of ≤ 9.0% (n = 75). Each group was divided into subgroups: Ia (n = 50) and IIa (n = 38) included adolescents with diabetic retinopathy, nephropathy or neuropathy, whereas groups Ib (n = 15) and IIb (n = 37) were without microvascular complications. The control group consisted of 36 adolescents with normal body weight, without carbohydrate metabolic disorders, and family history of diabetes mellitus. Determination of TNFα, IL-1β, VCAM-1, fractalkine levels in blood serum was performed by enzyme immunoassay using test systems “RayBiotech” (USA), “BIOSCIENCE” (USA).

Development of microangiopathies in adolescents with different glycemic control is associated with increased serum concentration of the factors involved in neoangiogenesis and vascular wall remodeling, i.e., TNFα, IL-1β, VCAM-1, compared with control group (p < 0.05), and a statistically significant decrease in fractalkine level in adolescent patients with either complicated, or uncomplicated DM1. The study allowed us to suggest that occurrence of microvascular complications in adolescents with DM1 is associated with impaired immune response tending for altered cytokine balance towards Th1 type, enhanced intercellular interactions, imbalance of bioregulatory molecules, contributing to development of inflammatory immunoregulatory state. The revealed patterns of laboratory markers, along with assessment of metabolic indices, will enable personalized approaches to early diagnostics of microvascular complications in adolescents with DM1 and prevent their further progression.
Contents of chemokines in lacrimal fluid of the patients with diabetic retinopathy and type 2 diabetes mellitus
Authors: Agarkov N. M. , Lev I. V.
Published: November 2022

Diabetic retinopathy is a serious microvascular complication of diabetes mellitus with chemokines playing an important pathogenetic role. However, the studies of chemokines in lacrimal fluid of the patients with diabetic retinopathy and type 2 diabetes mellitus (T2DM) are rarely performed. The aim of the study was to analyze the content of chemokines in lacrimal fluid of patients suffering from diabetic retinopathy and T2DM. When determining the concentration of chemokines in the lacrimal fluid, two clinical groups were formed: the main group of 56 elderly patients suffering from diabetic retinopathy and T2DM, and a control group of 48 age-matched persons with T2DM, however, without diabetic retinopathy. The diagnosis of diabetic retinopathy was performed after comprehensive ophthalmological examination using various modern techniques and applying the criteria of the All-Russian Association of Ophthalmologists “Diabetes mellitus: diabetic retinopathy, diabetic macular edema”. The chemokine levels in the lacrimal fluid were determined in the morning on the MAGPIX device (USA). The changed contents of chemokines was shown in lacrimal fluid of patients with diabetic retinopathy and T2DM, in comparison with patients suffering from T2DM in absence of diabetic retinopathy. In elderly patients with diabetic retinopathy and T2DM, a decreased content of GROα/ CXCL1, RANTES/CCL5 and MIP-1α/CCL3 was revealed in lacrimal fluid, at a statistically significant difference as related to controls. At the same time, the content of GROα/CXCL1 chemokine in lacrimal fluid was decreased most significantly, (38.24±2.57 in the main group versus 13.61±1.74 pg/mL in the comparison group). The level of RANTES/CCL5 decreased to 0.92±0.16 pg/mL versus 1.69±0.18 pg/mL (p < 0.001); MIP-1α/CCL3, to 2.06±0.71pg/mL versus 3.79±0.64 pg/mL, respectively. However, the proportion of chemokines in the lacrimal fluid of patients with diabetic retinopathy and T2DM was significantly inceased in  all  cases.  This  finding  concerns  MCP-1/CCL2,  IP-10/CXCL10,  and  SDF1α/CXCL12.  The  content  of IP-10/CXCL10 in lacrimal fluid increased to maximal values of 38.24±2.57 pg/mL in the patients with diabetic retinopathy and T2DM compared with 13.61±1.74 pg/mL in patients with diabetes mellitus without diabetic retinopathy, MCP-1/CCL2 to 742.34±0.89 pg/mL compared to 633.72±0.64 pg/mL, respectively; SDF1α/ CXCL12, to 264.78±7.82 pg/mL compared to 213.49±6.08 pg/mL. In addition, the interrelations between studied chemokines in patients with diabetic retinopathy and type 2 diabetes mellitus are more pronounced than in comparison group as confirmed by large number of correlations in the main group. The results obtained expand the knowledge on the effects of chemokines in lacrimal fluid upon development of diabetic retinopathy.
Epidemiology and course of infectious diseases during the covid-19 pandemic. Report 2. Interference engaged between SARS-COV-2 and acute respiratory viral infections
Authors: Boeva Ekaterina V. , Belyakov Nikolay A. , Simakina Olga E. , Danilenko Daria M. , Lioznov Dmitry A.
Published: November 2022

Currently, the disease caused by the new coronavirus (COVID-19) and the possibility of co-infection with SARS-CoV-2 and other pathogens in the current epidemic situation continues to be of particular interest. The review, based on the analysis of literature and own materials, outlines the features of the relationship between SARS-CoV-2 and pathogens of acute respiratory viral infections (ARVI). Particular attention is paid to the combined course of COVID-19 and influenza, a comparative characteristic of the severity of the clinical picture. An assessment of the epidemic situation against the backdrop of the COVID-19 pandemic in foreign countries and the Russian Federation (RF) revealed the presence of the phenomenon of SARS-CoV-2 interference with other viral respiratory agents, based on the facts of a sharp suppression of the circulation of influenza viruses, respiratory syncytial virus (RSV) and other ARVI pathogens during the period of active spread of pandemic coronavirus. The main epidemiological indicators of the course of coronavirus infection were compared and the contribution of various pathogens to the etiology of acute respiratory viral infections during the development of the second wave of COVID-19 in the RF was assessed. It was noted that the decrease in the number of new cases by 11.4 and deaths by 2.1 times due to COVID-19 at 6 and 13 weeks in 2022 occurred with unchanged laboratory detection of the influenza virus (0.8%) and an increase in the frequency detection of pathogens of other SARS. The results of observations showed that against the background of a decrease in the incidence of COVID-19, there was no increase in the proportion of diagnosed cases of infections caused by other pathogens, especially influenza. The results obtained confirm the need to ensure effective epidemiological surveillance and additional application of pathogen identification methods for monitoring various ARVI, which can significantly affect the approach to differential diagnosis, patient management tactics and the decision on appropriate preventive measures.
Post-Gam-COVID-Vac combined vector vaccine cellular and humoral immune response
Authors: Inviyaeva Evgeniya V. , Vtorushina Valentina V. , Drapkina Yulia S. , Krechetova Lyubov V. , Dolgushina Nataliya V. , Khaidukov Sergey V.
Published: November 2022

Currently, as the SARS-CoV-2 pandemic evolves, there has been increasingly more attention paid to building natural and vaccine-induced immunity against SARS-CoV-2 and related disease known as COVID-19. Widespread preventive vaccination plays an important role in effectively protecting people from viral infections and can reduce national economic costs. Purpose to study peripheral blood cell subset composition and magnitude of humoral response in vaccinated Gam-COVID-Vac subjects. The prospective study included 352 patients, of which 194 (119 women and 75 men) underwent an immunogram study and assessed level of anti-SARS-CoV-2 antibodies. In patients, the study of the lymphocyte subset composition and estimation of anti-SARS-CoV-2 antibodies was carried out at two time points prior to vaccination and 90 days after inoculated component 1 of the Gam-COVID-Vac vaccine. In general, vaccination was well tolerated by patients, with no serious adverse events after immunization. The reaction to the vaccine (fever, malaise, headache, local reactions) was short-term (12 days) and more often noted after inoculated vaccine component 2. Comparatively analyzed immunogram parameters in females before and after vaccination revealed increased relative level of T-lymphocytes (CD3+), T-helper cell subset (CD3+CD4+), increased absolute and relative level of activated CD3+CD25+ T-lymphocytes, but decreased absolute and relative level of natural killer (CD3CD56+CD16+) and natural killer T-cell (CD3+CD56+CD16+) cell subsets as well as decreased CD147 receptor expression on T-lymphocytes. Similar patterns were also found while examining the immunogram in males exepting increased level of lymphocytes and lowered CD147 expression on both T- and B-lymphocytes. No changes in the parameters of the immune T-cell arm was found. The high efficacy of the vaccine was confirmed by development of SARS-CoV-2-specific class G antiviral antibodies in 97.5% and 92.3% of vaccinated females and males, respectively. The data obtained evidence that: 1) vaccination induces a specific humoral immune response determined three months post-vaccination, and 2) it caused no serious disturbances in the immune system functioning, which could be reflected in the peripheral blood lymphocyte subset composition. Thus, the data presented allow to conclude that Gam-COVID-Vac is effective vaccine against SARS-CoV-2 infection.
Seroprevalence of tick-borne diseases in the Northwest Federal District of the Russian Federation
Authors: Tokarevich N. K. , Blinova O. V. , Stoyanova N. A. , Baimova R. R. , Siuziumova E. A. , Lomonosova V. I. , Tronin A. A. , Buzinov R. V. , Sokolova O. V. , Gnativ B. R. , Buts L. V. , Bubnova L. A. , Safonova O. S. , Stankevich A. I. , Kalinina E. L. , Vikse R. , Andreassen A. K.
Published: November 2022

Introduction. Knowledge about tick-borne disease (TBD) distribution is necessary to improve prevention, whereas detection of human serum IgG antibodies against relevant pathogens is a method for monitoring TBD prevalence in local population. The study objective was to estimate seroprevalence of IgG antibodies against tick-borne encephalitis virus (TBEV), Borrelia burgdorferi sensu lato, Coxiella burnetii, Anaplasma phagocytophilum, and Ehrlichia chaffeensis/E. muris in healthy residents from the five territories of the Northwestern Federal District of the Russian Federation (Arkhangelsk Oblast, Leningrad Oblast, Pskov Oblast, the Republic of Komi and the Republic of Karelia). Materials and methods. In 20172019, a total of 1244 serum samples from healthy residents, not vaccinated against TBDs or other flavivirus-caused infections was studied by ELISA. Results. 21.7% of the sera samples contained IgG antibodies against a single TBD pathogen, whereas 2.1% showed signs of coinfection with two or more pathogens. The most common were IgG antibodies against TBEV (5 territories, 12.2%), followed by Borrelia burgdorferi sensu lato (5 territories, 3.5%), C. burnetii (4 territories, 2.9%), Anaplasma phagoсytophilum (3 territories, 1.6%), E. chaffeensis/E. muris (5 territories, 1.5%). The IgG antibodies were more common in men (55.2%) than in women (44.8%), being found virtually evenly in age-independent manner (from juniors under 18 to seniors over 60). Conclusion. The results of this first comprehensive serosurveillance study in the Northwestern Federal District of the Russian Federation assessing serum IgG antibodies against tick-borne diseases indicate a wide distribution of such pathogens. Moreover, infections caused by C. burnetii, Anaplasma phagocytophilum, and Ehrlichia chaffeensis/E. muris might be highly underdiagnosed.
Serogroups and antimicrobial susceptibility of Salmonella isolated from people and food items in southern provinces of Vietnam
Authors: Egorova Svetlana A. , Truong Q. N. , Kaftyreva L. A. , Kozhukhova E. A. , Makarova M. A. , Cuong Q. H. , Vu H. N. , Huong T. D. , Lan T. Q.T. , Tram K. V. , Long T. N. , Diep T. N.N. , Tu L. K.B. , Thu L. K.N.
Published: November 2022

This article presents current relevant data on the serogroups and antimicrobial susceptibility of Salmonella strains isolated in the southern provinces of the Socialist Republic of Vietnam. There were examined 189 Salmonella strains isolated from: human feces in acute diarrhea (86 strains); and pork samples (103 strains). Serological O-group identification was performed by slide agglutination with O- and H-antisera and multiplex PCR to detect H phase-1 and phase-2. Antimicrobial susceptibility testing was performed by using the disk-diffusion method according to the EUCAST (version 2019) recommendations. Strains isolated from humans predominantly belonged to O4 group (69.8%). The percentage of other serogroups varied from 1.2% (rare group O16) to 11.6% (O9). About a half of strains (44.7%) isolated from pork samples turned out to belong to the О3,10 serogroup (vs 7.0% of strains from humans). Serogroups О7, О4 and О8 were less frequent (22.3%, 14.6% and 13.6%, respectively). Single strains belonged to serogroups О9, О13, and О18. Regardless of the isolation source, about 80% of Salmonella strains were resistant to antibiotics from different antimicrobial groups (besides carbapenems): 67.0% were resistant to tetracycline; about half were resistant to pefloxacin, ampicillin and chloramphenicol (54.0%, 47.1%, 46.6%); and up to 40% were resistant to trimethoprim/sulfamethoxazole and nalidixic acid. The proportion of strains resistant to ceftriaxone and gentamycin was markedly higher in those of human vs pork origin: 12.8% vs 1.0% and 30.2 vs 1.9%, respectively. Moreover, 62.8% and 43.7% strains of human and pork origin, respectively, showed multidrug resistance (to 3 and more antimicrobial groups). In addition, simultaneous resistance to 6 antimicrobial groups was detected much more frequently in Salmonella strains isolated from humans vs pork samples (15.1% vs 1.0%, respectively). Multidrug resistance (MDR) was observed in strains of different serovars, predominantly S. Typhimurium (36.4%). The predominant MDR (30.3%) phenotype (AMP, TE, QN, C, SXT) was revealed in serovars of S. Typhimurium, S. Bredeney, S. Corvallis, S. Give, S. London, S. Rissen, and S. Meleagridis. Thus, Salmonella strains isolated in the southern Vietnamese provinces featured resistance to fluoroquinolones and cephalosporins. Taking into account simultaneous loss of susceptibility to old antimicrobials (ampicillin, chloramphenicol, trimethoprim/sulfamethoxazole), it crucially restricts the list of effective medicines to treat complicated salmonellosis cases.
The influence of Aspergillus fumigatus micromycetes on immune response regulation in patients with asthma
Authors: Kozlova Yana I. , Frolova E. V. , Kudryavtsev I. V. , Uchevatkina A. E. , Filippova L. V. , Aak O. V. , Taraskina A. E. , Sobolev A. V. , Vasilyeva N. V. , Klimko N. N.
Published: November 2022

Introduction. Aspergillus fumigatus is able not only to sensitize patients with atopy, but also to colonize the respiratory tract, remaining a constant source of allergens due to the small spore size and thermal tolerance. Currently, the role of micromycetes in the immunopathogenesis of asthma has been poorly studied. The objective was to evaluate the features of the immune response regulation in patients with allergic bronchopulmonary aspergillosis (ABPA) or asthma with sensitization to A. fumigatus. Materials and methods. There were enrolled 15 patients with ABPA, 10 patients with asthma with sensitization to A. fumigatus, 16 patients with asthma without sensitization to A. fumigatus. The control group consisted of 16 apparently healthy volunteers. All patients underwent a clinical and functional examination. The subpopulations of blood lymphocytes were assessed by flow cytometry. The A. fumigatus allergen was added to peripheral blood samples to evaluate the production of IFN, IL-10 and IL-13. The serum cytokine levels in cell culture supernatants, as well as total IgE, A. fumigatus-specific IgE (sIgE) as well as thymus and activation-regulated chemokine (TARC) level were measured by enzyme-linked immunosorbent assay. Results. Significantly higher serum levels of total IgE, A. fumigatus-specific sIgE and TARC were found in patients with ABPA and asthma with sensitization to A. fumigatus compared to patients with asthma without sensitization to A. fumigatus. The results of lymphocyte immunophenotyping revealed significant excess of memory Th2 cells and T-regulatory cells in all patients with asthma compared to the control group. The count of Tfh2 was higher but memory Th17.1 cells were lower in patients with sensitization to A. fumigatus compared to those of apparently healthy volunteers. Patients with ABPA had significantly higher count of memory Th2 cells and TARC level compared to patients with asthma sensitized to A. fumigatus. The increased activity of memory Th2 cells is confirmed by increased secretion of IL-13 and IL-10 following along with decreased IFN production in response to specific fungal allergen stimulation of blood cells compared to the patients with asthma and the control group. A positive correlation was revealed between the count of memory Th2 cells and the levels of sIgE, IgE, TARC, a negative correlation with FEV1. Conclusion. Thus, exposure to A. fumigatus significantly enhances the activity of memory Th2 cells in patients with asthma which can lead to severe disease course and development of allergic bronchopulmonary aspergillosis. The features of the immune response identified dictate a need for a personalized approach to choose therapeutic tactics in such patients.
The effect of the firing rate on the properties of chamotte from kaolin Kyshtym deposit
Authors: Yakovleva O. V. , Kashcheev I. D. , Zemlyanoi K. G.
Published: November 2022

Исследовано влияние скорости обжига обогащенного каолина Кыштымского месторождения на свойства шамота. Спецификой каолина Кыштымского месторождения является петрографическое разнообразие исходных пород, что отрицательно сказывается на его качестве как огнеупорного сырья. Изучены пластические свойства каолина, позволяющие формовать брикет без дополнительного использования связующих, включая воду. Исследования скорости, конечной температуры обжига и длительности выдержки при конечной температуре показали, что скорость подъема температуры в процессе обжига шамота несущественно влияют на качество получаемого шамота. В то же время повышение конечной температуры обжига и выдержки существенно влияет на качество и фазовый состав шамота, закономерно снижая его водопоглощение, увеличивая выход муллита и уменьшая количество непереродившегося свободного SiO2. Установлено, что максимальная температура обжига обогащенного каолина Кыштымского месторождения на шамот составляет 1350‒1400 оС, скорость подъема температуры 35‒45 оС/мин.
To extract or not to extract – Felicific calculus to the rescue
Authors: Motloba Pagollang , Moipolai Pusetso , Mtolo Thembelihle M , Mpungose Sandile
Published: November 2022

Contestations about the most appropriate clinical intervention and preferred treatment modality remains a serious challenge in dental practice. Dentists must straddle a delicate line between coercion, medicalpaternalism and respecting patient’s interests and concerns. This paper explores a moral debate using a dental extraction case study, and felicific calculus as a tool for joint decision-making. We argue that this instrument offers an invaluable opportunity for building rapport and mutual engagement. Additionally, recognition of patient’s preferences must also be considered in the proposed clinical intervention to inculcate a sense of ownership of the interventions proposed for and by the patient. It is argued that, this will instill a sense of shared-decision making in the interaction between the patient and the clinician.
Achieving humidification of inspired gases in the delivery room for very preterm infants: Rationale and set up
Authors: Michael P Meyer , Jonathan Barrett
Published: November 2022

Nearly all very preterm infants will require some form of respiratory support in the neonatal unit. It is standard practice to humidify the inspired gases. It appears logical to bring this practice of humidification forward to the time immediately after birth. There is an evidence base for early provision of heated humidified gases in the delivery room, but because several forms of respiratory support may be needed (eg binasal prong CPAP and use of a T-piece resuscitator) this may be difficult to achieve. We describe a setup using a radiant warmer and humidification circuits to make this possible.
Open Abdominal Management Among Non-Trauma Patients: The Appropriate Duration and a New Clinical Index
Authors: Inukai Koichi , Usui Akihiro , Hashimoto Yu , Kato Fumitaka , Amano Koji , Kayata Hiroyuki , Mukai Nobutaka , Shinyama Naoki
Published: November 2022

Purpose: Despite widespread adoption of open abdominal management (OAM), there is currently no threshold criterion for OAM duration for non-trauma patients. Moreover, there is a positive relationship between morbidity and the duration of OAM, but an uncertain relationship with patients’ age. Therefore, a novel clinical index for the duration of open abdominal management (IDOM) was developed based on the patient’s age and risk of severe complications following OAM to indicate the maximum tolerable number of days of OAM based on the individual’s age. The utility of this new index was evaluated.Methods: This retrospective study included 65 non-trauma patients managed with an open abdomen (OA) from August 2015 to August 2018. The IDOM was developed based on the patient’s age. The result indicated the maximum number of OA days. Patients’ demographic and operative variables were examined and patient data was assigned to one of two groups according to whether the actual number of OA days was above or below the calculated IDOM. Prevalence of complications between these groups was compared. Measures of validity were employed to assess the utility of the IDOM for patient complications.Results: Sixty-five patients were included. The above-the calculated IDOM group exhibited a significantly longer OA and higher rates of wound complications and postoperative respiratory complications compared with the below the calculated IDOM group. The IDOM predicted the incidence of OA-related complications with a sensitivity of 72.4%, and a specificity of 80.6%.Conclusion: The IDOM is a potentially useful tool for appropriate duration at the outset of OA.
Distanciamento social na pandemia da COVID-19 e estado emocional de estudantes universitários: estudo descritivo-exploratório
Authors: Gama Liasse Monique de Pinho , Souza Verusca Soares de , Lopes Soraia Geraldo Rozza , Arruda Guilherme Oliveira de , Lima Helder de Pádua , Baptista Cremildo João
Published: November 2022

Objetivo: Conhecer a vivência com o distanciamento social, no período inicial da pandemia da COVID-19, e o estado emocional de estudantes universitários. Método: Estudo qualitativo, exploratório-descritivo, realizado com 237 estudantes de instituição de ensino superior pública, situada no centro-oeste brasileiro. Dados coletados virtualmente, por questionário eletrônico, lançados em planilha e submetidos à análise descritiva e de conteúdo temática. Resultados: Emergiram as categorias Entre mudanças emocionais e dificuldades de adaptação ao ensino remoto e Distanciamento social e aproximação com o próprio ser. As narrativas sugerem a vivência de preocupações, ansiedade, abalo e instabilidade emocional com o distanciamento social e o ensino remoto de emergência no período pandêmico, e denotam maior tempo para o autocuidado e a convivência em família. Conclusão: Faz-se necessário o desenvolvimento de estratégias intersetoriais de promoção da saúde e prevenção de transtornos mentais, em parceria com a instituição de ensino, ajustadas ao contexto.
MEMORY PRACTICES IN FORMATION OF SCHOOLCHILDREN’S CIVIC IDENTITY
Authors:   Omsk State Pedagogical University, Chukhin S. G. , Chukhina E. V. ,   Omsk State Pedagogical University
Published: November 2022

The relevance of the study relates to the crisis phenomena in the theory and practice of the formation of Russian civic identity of students in modern socio- cultural conditions, the need to find new methods, approaches and issues of psychological and pedagogical support for the socialization of a citizen in modern society. The condi- tions and possibilities of using commemoration as the most important tool for the deve- lopment of historical memory are considered. The article presents the theoretical substan- tiation of the use of memory practices as a basic educational activity in the formation of civil identity of schoolchildren. The directions for the development of historical memory research in modern his- tory and sociology are identified on the basis of the analysis of current domestic and Eng- lish-language scientific works. The structure of commemorative practice as a mechanism for the formation of the Russian civic identity of students is described. The author's forms of organizing memory practices in the field of civic education of schoolchildren are pro- posed. It is concluded that it is necessary to study the possibilities of commemorative practices in organizing educational work, which determines the need to adapt to the tasks of pedagogical research methods and techniques of memory history and enables to expand the field and potential of the formation of the Russian civic identity of students.
PSYCHOLOGICAL AND PEDAGOGICAL PROFILE OF MODERN SCHOOLCHILDREN AS DIGITAL NATIVES
Authors:   Pacific National University, M. D. Osadchy
Published: November 2022

The article analyzes the characteristics of digital generation — a changing stu-dent profile in an uncertain world. Based on the cultural and historical approach and the theory of generations, we have attempted to reconstruct the psychological and pedagogical profile of modern schoolchildren as digital natives. The article summarizes the scientific facts about the influence of information and communication technologies on different spheres of a children's life. We have divided the considered changes into four groups that characterize the digital socialization of schoolchildren: higher mental functions, mecha-nisms of personal development, forms and means of communication with others, cultural and social practices. When studying the influence of digital technology on the develop-ment and behavior of students, we have mainly used a non-evaluative approach, and con-sidered many phenomena as a given with its own specifics. An analysis of the changes makes it possible to reconstruct a new psychological and pedagogical profile of school-children and will stimulate the search for new ways to solve a wide range of problems in upbringing and teaching, including the historical education.
DESIGN OF LEARNING TASKS IN HISTORY DEVELOPING PERSONAL RESULTS WITHIN THE FRAMEWORK OF UPDATED FSES
Authors:   Malyakov Secondary School No. 24, O. G. Vishneva
Published: November 2022

The issue of achieving the results of mastering the basic educational programs is of particular relevance in the context of the practical implementation of the updated Federal State Educational Standards in the primary school. The article deals with learning tasks in history that form a group of personal results in different types of lessons in grades 6–10. The training tasks proposed by us cover all spheres of the development of personal results (patriotic education, civic education, spiritual and moral sphere, understanding of the value of scientific knowledge, aesthetic education, formation of a value attitude to life and health, labour and environmental education, adaptation to the changing conditions of social and natural environment) named in the Exemplary Work Program on History, have a variety of forms, and in some cases are directly related to the local history of Transbaikalia and the Pskov land. The article notes the significant educational potential of the discipline “History” for the formation of the internal position of students. Being in-cluded in a variety of activities in history lessons, students gain experience in exploring life meanings, understanding values, orientation in moral standards, which means they can develop their own existential attitude towards the world around them (nature, society) and themselves.
Немецкий и французский языки в современном языковом пространстве: традиции и инновации
Authors:   Buryat State University
Published: November 2022

This edition is a collection of papers within an international research to practice seminar on linguistics and language didactics. The collection includes articles by researchers from educational and academic institutions of Russia, Kazakhstan, Germany, Austria and France. The papers consider issues of modern linguistics and the foreign language teaching theory and practices. The edition addresses a wide range of academics: linguists, teachers, translators, and other participants of intercultural interaction.
Admission HbA1c value as a prognostic marker in patients admitted with COVID-19
Authors: Jain Vaibhav , Hegde Suraj S.
Published: November 2022

Background: Diabetes mellitus has been firmly established as a risk factor for the prognosis of COVID-19. However, the impact of pre-COVID-19 glycemic control on prognosis is yet to be fully understood. Our study aimed to establish the effect of HbA1c at admission on the outcome of patients admitted with COVID-19.Methods: It was a prospective observational study of admitted adult patients with confirmed SARS-CoV-2 infection in a tertiary care centre based on data collected from the medical record section using the patient data registry between April 2021 to June 2021. Information regarding demographic and clinical features, laboratory values, and hospital outcomes was collected and analysed.Results: 182 patients admitted to the hospital with COVID-19 during the study period were included, their mean age was 48.75 years, the mean HbA1c was 6.1. Males accounted for 69.8% (127) of the sample population. 41.2% (75) were known diabetics. 44.8% (81) were known hypertensives. The mortality rate overall was 25.3% (46). 63.7% (116) had HbA1c values >6.5. High HbA1c values was associated with longer duration of hospital stay (p=0.032), higher levels of inflammatory markers, increased need for mechanical ventilation (p=0.001), higher mortality rate (p=0.001).Conclusions: Patients with COVID-19 with poor glycemic control as evidenced by admission HbA1c levels were found to have more severe disease course with increased level of inflammatory markers, longer duration of hospital stay and higher risk of mortality.
An interesting case of melioidosis: a mimicry of pulmonary tuberculosis
Authors: Sivasamy Manoj , R. Shreenidhi , M. K. Nishaanth , M. Jagadeesan , S. Prasanna Karthik
Published: November 2022

Melioidosis is caused by Burkholderia pseudomallei which is a soil-dwelling aerobic bacterium reported mostly in tropical and subtropical areas, especially in Asia (Southeast) and Australia (Northern part). Melioidosis is a severe infection that can manifest as chronic debilitating pneumonia mimics pulmonary tuberculosis. Here, we reported a case of melioidosis, in 51-year-old men with poorly controlled type 2 diabetes mellitus. The patient recovered with appropriate intravenous antibiotics and supportive medications.
Neuromyelitis optica presenting as neurogenic bladder
Authors: Aryadevi C. P. , Pradeep Geethika , Bhargavan P. V. , P. V. Shiji
Published: November 2022

Neuromyelitis optica (NMO) is an immune mediated disease of central nervous system primarily affecting optic nerves, spinal cord and brain stem. This case report describes a 24-year-old male with no comorbidities presented with high grade fever followed by proximal lower limb weakness and bilateral hydrouretero nephrosis without any lower urinary tract obstruction. He had clinical features of conus- cauda lesion with MRI spine showing features of longitudinally extensive transverse myelitis (LETM) and brain MRI showing involvement of splenium of corpus callosum. He improved with steroid therapy with in a period of 2 weeks and oral steroid was tapered of and stopped within a period of two months. There was no relapse of symptoms so far.
Actual use puffing topography and mouth level exposure to aerosol and nicotine for an evolving series of electronic nicotine delivery systems
Authors: Prasad Krishna , Gray Adam , Edward Lauren
Published: November 2022

Electronic nicotine delivery systems (ENDS) have evolved substantially in the past 10 years from disposable “cig-a-likes” to rechargeable devices with refillable tanks or disposable cartridges. It is less clear whether users’ puffing behaviour and exposure to aerosol emissions has similarly altered. Here we evaluate changes in the puffing topography and mouth level exposure (MLE) of users to aerosol and nicotine for a series of commercially available ENDS. In five separate consumer studies conducted from 2014 to 2019, eight Vuse ENDS including cig-a-likes, tanks, pen- and pod-style e-cigarettes were evaluated among ENDS users (total n=221) for puff duration, puff volume, inter-puff interval and MLE to aerosol and nicotine. Puff volumes varied two-fold (35.7-84.8 ml) with the lowest volumes for early ENDS and highest volumes for more recent pod style and tank systems. The variation in puff duration across the devices was smaller (1.70-2.39 s), especially for the five most recent devices (2.13-2.39 s). MLE to aerosol (1.9-6.4 mg/puff) tended to increase with evolution of the ENDS. MLE to nicotine, which depends on the nicotine concentration of the e-liquid as well as device design, was also highest for more recent devices. These data indicate that evolving device characteristics, such as more powerful batteries and aerosolisation technology, influence user puffing topography and the values obtained from one product might not apply to others. Continuing to evaluate ENDS consumer behaviour is important to understand further the factors that affect users’ puffing topography and nicotine uptake from these products.