bluuebunny/crossref_metadata_2025 huggingface dataset:
Journalistification, Transnationalism and Critique in Swedish Television’s Cultural Magazine Kobra (2001−2017)
Authors: Riegert Kristina
Published: July 2024

The cultural magazine Kobra (2001−2017) was one of the longest running shows in Swedish public service television history. Kobra defined culture broadly as arts, popular culture and subcultures, both international and Swedish. The study uses three lenses—journalistification, transnationality and cultural/societal criticism—to analyze how Kobra evolved over its long run. It focuses on four globally eventful years 2001, 2005, 2011, and 2016 and shows how the shifting SVT mandate is reflected in the show’s title sequences, program structure, visual features, and text. Transnationality becomes established through topic themed episodes connecting various cultural domains in different parts of the world or through country/city-themed episodes. A close reading from three different years reveals that Kobra exercised transnational systemic criticism through the choice of theme and interview subjects, rather than through evaluation of cultural expression, in line with its increasing journalistification and public service mandate.
Fitting mixed random regret minimization models using maximum simulated likelihood
Authors: Zhu Ziyue , Gutiérrez-Vargas Álvaro A. , Vandebroek Martina
Published: July 2024

In this article, we describe the mixrandregret command, which extends the randregret command introduced in Gutiérrez-Vargas, Meulders, and Vandebroek (2021, Stata Journal 21: 626–658) by allowing random coefficients in random regret minimization models. The newly developed mixrandregret command allows the user to specify a combination of fixed and random coefficients in the regret function of the classical random regret minimization model introduced in Chorus (2010, European Journal of Transport and Infrastructure Research 10: 181–196). In addition, the user can specify normal and lognormal distributions for the random coefficients using the appropriate command’s options. The models are fit by maximum simulated likelihood estimation using numerical integration to approximate the choice probabilities.
Outcomes of Pedicled Groin Flaps for Upper Extremity Injuries
Authors: Devarasetty V. V. N. Manohar , Vickery Justin W. , Maslow Jed I.
Published: July 2024

Background:

Free flap reconstruction has become the more common treatment over pedicled groin flaps for reconstruction of upper extremity injuries in recent years. Groin flaps are still used for a variety of reasons, though limited literature is available to guide surgeons and patients regarding outcomes. This study aimed to investigate the epidemiology and outcomes of pedicled groin flaps for upper extremity pathology.

Methods:

The study was a single-institution retrospective case series at a level one trauma center including patients who underwent pedicled groin flaps for upper extremity soft tissue coverage between 1992 and 2022. The data collected included patient and injury characteristics, surgical management, and complication data. Ordinal logistic regression, univariate analysis, and bivariate analysis were performed to assess the relationship between the total number of groin flap surgeries and complications with patient and injury characteristics.

Results:

The analysis included 88 pedicled groin flaps performed for upper extremity injuries, with a median follow-up of 1.14 years after injury. Patients had a median age of 35 (interquartile range [IQR]: 22-49) years and underwent a median of 4 (IQR: 3-5.25) surgeries with stiffness (90.6%), partial flap loss (38%), and infection (32%) as the most common complications. High-energy injuries increased the risk of requiring more surgeries based on ordinal logistic regression. Univariate and bivariate analysis revealed no significant difference in wound complications based on patient or injury characteristics.

Conclusions:

Patients undergoing pedicled groin flaps for upper extremity injuries can expect to undergo an average of 4 surgeries, and high-energy injuries predict the need for more surgeries.
Going for gold: Professionals’ perspectives on the design and implementation of transformative coercive control offences in Scotland and England and Wales
Authors: Bettinson Vanessa , Munro Vanessa E , Burton Mandy
Published: July 2024

This study provides the first analysis of prosecutors, members of the judiciary, voluntary organizations, and police officers’ perspectives about the implementation of coercive control offences. In terms of the design, requiring proof that the prohibited conduct caused a serious effect on the victim-complainant means a continued focus on the victim’s engagement with the criminal justice processes in England, leading to the under-utilisation of evidence-led investigations. This can be positioned in contrast to the approach taken in Scotland by police and prosecutors, where there was greater confidence expressed regarding evidence-led investigation, though this was potentially undermined at the judicial level where victim engagement and performance in court continued to be a main focus. This, we suggest requires continued training for all professionals to ensure that an understanding of the dynamics of coercive control are embedded at each stage of the criminal justice process.
Factors Affecting Choice of Surgical Treatment of Cartilage Lesions of the Knee: An Analysis of Data From 5143 Patients From the German Cartilage Registry (KnorpelRegister DGOU)
Authors: Gebhardt Sebastian , Vollmer Marcus , Zimmerer Alexander , Rochel Ingo , Balcarek Peter , Niemeyer Philipp , Wassilew Georgi I.
Published: July 2024

Background:

Symptomatic full-thickness cartilage lesions of the knee joint are considered an indication for cartilage repair surgery. Patient- and lesion-specific factors like age, nutritional status, etiology of defect, or integrity of corresponding joint surface remain controversial in indicating cartilage repair surgery. Furthermore, the selection of the most suitable cartilage repair technique for a specific cartilage lesion remains debatable.

Purpose:

To evaluate indications and choice of treatment method for cartilage repair surgery, depending on patient- and lesion-specific data from the German Cartilage Registry.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

A total of 6305 consecutive patients who underwent cartilage repair surgery of the knee evaluated and 5143 complete datasets were included in the analysis (follow-up rate, 81.5%). Patient-specific (age, body mass index, smoking status, previous operations, clinical leg axis) and lesion-specific (size, grading, location, etiology) data were provided by the attending surgeon at the time of surgery. Appropriate statistical tests were used to compare data depending on type and normality of data. Multivariable logistic regressions were calculated to investigate independent factors for the choice of specific cartilage repair techniques.

Results:

The median size of treated cartilage lesions was 3.6 cm2, and most defects were of degenerative origin (54.8%). Of the registered patients, 39.2% were categorized as overweight and 19.6% as obese, while 23.3% were smokers. The most prevalently documented operative techniques were the autologous chondrocyte implantation (ACI) (52.4%), bone marrow stimulation (BMS) (17.3%), and BMS augmented with collagen scaffolds (9.3%). Independent factors that made the use of ACI more likely were bigger lesion size, previous surgery at the joint, and lesions located at the trochlea or the patella. On the contrary, BMS or augmented BMS were preferred in older patients, with damaged corresponding joint surface, and with more concomitant surgeries.

Conclusion:

Cartilage repair surgery was indicated irrespective of nutritional status, smoking status, or etiology of the treated lesion. ACI was the most prevalent technique and was preferred for younger patients and patellar lesions. While older patients with degenerative changes to the joint were not excluded from cartilage repair surgery, the use of ACI was restricted.
Reaching the hinterlands? COVID-19’s unexpected challenges to conducting participatory research on Inuit Arctic politics
Authors: Ahlness Ellen A.
Published: July 2024

The Arctic is a strange sort of hinterland. While geographically distant from most global decision-makers, its role in global economics—and therefore politics—are increasingly centered in international dialogue. Early 2020, 2 years into a 4-year project studying the political organization and strategies of Canadian and American Inuit, a policy project’s research design and methodology were thrown into upheaval due to the COVID-19 pandemic. Travel to the Far North became impossible, and already stressed participants became at risk of even greater burnout. These changes necessitated rapid pivoting and methodological flexibility to finish data collection in a rigorous way to allow for subsequent trustworthy thematic content analysis.

Subsequent methodological choices and use of digital technologies demonstrated the importance of design flexibility and benefits of data stream merging: findings validated across multiple data sources were more trustworthy. The process also necessitated continuous researcher self-evaluation of whether data collection practices truly enhanced the project. These lessons learned may inform future projects involving Indigenous communities or other populations at risk of disproportionate participant burnout and support the accessibility of projects involving remote populations. Further, they encourage centering research design choices around respect for participants.
Limits of self and Other xenosophic responsiveness: Including complex emotions, power differences and possible futures
Authors: Sullivan Gavin Brent , Wijayanti Aldani Putri
Published: July 2024

In a complementary commentary on Streib, we highlight complexities of self and Other responsiveness when researching and attempting to enact xenosophic alternatives to xenophobic relations with a wide range of others and including related problematic forms of personal and group ‘egocentricity’. Using our similar attempts to be reflexive in theory and practice about self and Other responsiveness in our own social, political, community and cultural psychology research (extending Streib’s focus on developmental psychology), we use the later philosophical approach of Ludwig Wittgenstein – rather than the phenomenological philosophy of Waldenfels – to explore instances of self and ‘extraordinary Other’ relations via examples of everyday and form-of-life disagreements. We then focus on complex emotions and investigations of affective and discursive patterned features of self and Other relations to highlight features of responsiveness and collective wisdom evident in a dynamic typology of group-based and collective pride, shame and guilt relations in contexts of celebration, competition, challenge and conflict. The need to explore the limits of self and extraordinary Other responsiveness is shown by considering how possible futures and power considerations might lead us to step back from potentially becoming other to ourselves.
Accounting for ground-motion uncertainty in empirical seismic fragility modeling
Authors: Bodenmann Lukas , Baker Jack W , Stojadinović Božidar
Published: July 2024

Seismic fragility models provide a probabilistic relation between ground-motion intensity and damage, making them a crucial component of many regional risk assessments. Estimating such models from damage data gathered after past earthquakes is challenging because of uncertainty in the ground-motion intensity the structures were subjected to. Here, we develop a Bayesian estimation procedure that performs joint inference over ground-motion intensity and fragility model parameters. When applied to simulated damage data, the proposed method can recover the data-generating fragility functions, while the traditionally used method, employing fixed, best-estimate, intensity values, fails to do so. Analyses using synthetic data with known properties show that the traditional method results in flatter fragility functions that overestimate damage probabilities for low-intensity values and underestimate probabilities for large values. Similar trends are observed when comparing both methods on real damage data. The results suggest that neglecting ground-motion uncertainty manifests in apparent dispersion in the estimated fragility functions. This undesirable feature can be mitigated through the proposed Bayesian procedure.
Pathogen stimulations and immune cells synergistically affect the gene expression profile characteristics of porcine peripheral blood mononuclear cells
Authors: Yang Jinyan , Chen Siqian , Ma Fuping , Ding Ning , Mi Siyuan , Zhao Qingyao , Xing Yue , Yang Ting , Xing Kai , Yu Ying , Wang Chuduan
Published: July 2024

Background

Pigs serve as a crucial source of protein in the human diet and play a fundamental role in ensuring food security. However, infectious diseases caused by bacteria or viruses are a major threat to effective global pig farming, jeopardizing human health. Peripheral blood mononuclear cells (PBMCs) are a mixture of immune cells that play crucial roles in immunity and disease resistance in pigs. Previous studies on the gene expression regulation patterns of PBMCs have concentrated on a single immune stimulus or immune cell subpopulation, which has limited our comprehensive understanding of the mechanisms of the pig immune response.

Results

Here, we integrated and re-analyzed RNA-seq data published online for porcine PBMC stimulated by lipopolysaccharide (LPS), polyinosinic acid (PolyI:C), and various unknown microorganisms (EM). The results revealed that gene expression and its functional characterization are highly specific to the pathogen, identifying 603, 254, and 882 pathogen-specific genes and 38 shared genes, respectively. Notably, LPS and PolyI:C stimulation directly triggered inflammatory and immune-response pathways, while exposure to mixed microbes (EM) enhanced metabolic processes. These pathogen-specific genes were enriched in immune trait-associated quantitative trait loci (QTL) and eGenes in porcine immune tissues and were implicated in specific cell types. Furthermore, we discussed the roles of eQTLs rs3473322705 and rs1109431654 in regulating pathogen- and cell-specific genes CD300A and CD93, using cellular experiments. Additionally, by integrating genome-wide association studies datasets from 33 complex traits and diseases in humans, we found that pathogen-specific genes were significantly enriched for immune traits and metabolic diseases.

Conclusions

We systematically analyzed the gene expression profiles of the three stimulations and demonstrated pathogen-specific and cell-specific gene regulation across different stimulations in porcine PBMCs. These findings enhance our understanding of shared and distinct regulatory mechanisms of genetic variants in pig immune traits.
Deciphering desiccation tolerance in wild eggplant species: insights from chlorophyll fluorescence dynamics
Authors: Khapte Pratapsingh S. , Changan Sushil S. , Kumar Pradeep , Singh T. H. , Singh Ajay Kumar , Rane Jagadish , Reddy K. Sammi
Published: July 2024

Background

Climate change exacerbates abiotic stresses, which are expected to intensify their impact on crop plants. Drought, the most prevalent abiotic stress, significantly affects agricultural production worldwide. Improving eggplant varieties to withstand abiotic stress is vital due to rising drought from climate change. Despite the diversity of wild eggplant species that thrive under harsh conditions, the understanding of their drought tolerance mechanisms remains limited. In the present study, we used chlorophyll fluorescence (ChlaF) imaging, which reveals a plant’s photosynthetic health, to investigate desiccation tolerance in eggplant and its wild relatives. Conventional fluorescence measurements lack spatial heterogeneity, whereas ChlaF imaging offers comprehensive insights into plant responses to environmental stresses. Hence, employing noninvasive imaging techniques is essential for understanding this heterogeneity.

Results

Desiccation significantly reduced the leaf tissue moisture content (TMC) across species. ChlaF and TMC displayed greater photosystem II (PSII) efficiency after 54 h of desiccation in S. macrocarpum, S. torvum, and S. indicum, with S. macrocarpum demonstrating superior efficiency due to sustained fluorescence. PSII functions declined gradually in S. macrocarpum and S. torvum, unlike those in other species, which exhibited abrupt declines after 54 h of desiccation. However, after 54 h, PSII efficiency remained above 50% of its initial quantum yield in S. macrocarpum at 35% leaf RWC (relative water content), while S. torvum and S. indicum displayed 50% decreases at 31% and 33% RWC, respectively. Conversely, the susceptible species S. gilo and S. sisymbriifolium exhibited a 50% reduction in PSII function at an early stage of 50% RWC, whereas in S. melongena, this reduction occurred at 40% RWC.

Conclusion

Overall, our study revealed notably greater leaf desiccation tolerance, especially in S. macrocarpum, S. torvum, and S. indicum, attributed to sustained PSII efficiency at low TMC levels, indicating that these species are promising sources of drought tolerance.
The effects of remimazolam combined with sufentanil on respiration, circulation and sedation level in patients undergoing colonoscopy
Authors: Sun Qirui , Cheng Jiating , Lei Weiping , Lu Xinlei , Huang Yaqin , Sun Jianliang
Published: July 2024

Background

The main sedative which is propofol in painless gastroenteroscopy, has a high risk of reducing blood pressure and respiratory depression. Remimazolam (a short-acting benzodiazepine) is expected to be widely used in painless gastroenteroscopy due to its rapid onset, rapid metabolism and light respiratory and circulation inhibition.

Methods

A randomized, single-blind, parallel, controlled study, 123 outpatients who were undergoing painless colonoscopy and ramdomly divided into group A, B and C, in Hangzhou First People’s Hospital, July-December 2021. All patients were intravenously injected with 5 µg sufentanil for analgesic preconditioning. The group A was induced by 0.2 mg/kg remimazolam besylate. The group B was induced by 0.25 mg/kg remimazolam besylate. And the group C was inducted by 2.0 mg /kg propofol. If the patients had limb movement or MOAA/S score > 3 and so on, remimazolam besylate was added at 2.5 mg/ time in group A and B, and propofol emulsion injection was added at 0.5 mg/kg/ time in group C. During the operation, according to the actual situation, remimazolam was per added 2.5 mg in the experimental group, and propofol was 0.5 mg/kg in the control group. Heart rate (HR), non-invasive blood pressure (BP), respiratory rate (RR), pulse oxygen saturation (SpO2), and improved vigilance/sedation score (MOAA/S) of patients was recorded from entering endoscopy room to get out of the anesthesia recovery room, also including perioperative adverse events, other medications or treatments, the time of patients waking up and leaving the hospital.

Results

The successful rate of induction in three groups was 100%. There was no significant difference in the sedation completion rate among the three groups (Group A:90.2%, Group B: 92.7%, Group C: 92.7%, P = 1.000). The rate of adverse events after administration: group A(27.0%) and B(36.8%) both lower than group C(71.0%),P < 0.001;There was no significant difference between group A and group B, P > 0.744;The average time from the last drug administration to meet the discharge criteria of the subjects in three groups was as follows: The average time of group A(16.2 min) and Group B(16.5 min) both shorter than group C(19.6 min), P = 0.001; There was no significant difference between group A and group B, P = 0.742. Conclusions: This study revealed that remimazolam is a safe and effective medication for colonoscopy sedation, the security of remimazolam is better than propofol, and the sedative effect with the initial dose of 0.25 mg/kg of remimazolam is optimal.

Trial registration

China Clinical Trial Center with registration number: 2100052615,02/11/2021.
Comparing the clinical features of lateral and medial approaches of costoclavicular technique versus traditional lateral sagittal technique as infraclavicular brachial plexus block methods: a randomized controlled trial
Authors: Bingül Emre Sertaç , Canbaz Mert , Güzel Mehmet , Şalvız Emine Aysu , Akalın Bora Edim , Berköz Ömer , Emre Demirel Ebru , Sungur Zerrin , Savran Karadeniz Meltem
Published: July 2024

Background

It is aimed to compare the block onset times and performance features of costoclavicular techniques (medial and lateral approach) versus lateral sagittal technique.

Methods

Patients were randomized into three groups. For costoclavicular techniques, ultrasound probe was placed parallel to clavicle obtaining nerve cords, axillary artery and axillary vein visual from lateral-to-medial, respectively. The block needle was advanced from lateral (Group CLB) or medial (Group CMB) to perform costoclavicular block. For lateral sagittal technique (Group LSB), ultrasound probe was placed sagittal and perpendicular below the coracoid process to obtain sagittal artery image with the cords around. Total 20 ml of 0.5% bupivacaine and 10 ml of 2% lidocaine were deposited for all groups. Sensory and motor block onset times, block performance properties, complications, and patient/surgeon satisfactions were investigated.

Results

Among 56 patients, the primary outcome, sensory block onset time was shorter in Group CLB than Group CMB and Group LSB (10 [5–15], 10 [10–20], and 15 [10–15] minutes, respectively, p < 0.05). Motor block onset was also fastest in Group CLB (15 [10–20] mins for CLB, 20 [15–20] mins for LSB, and 22.5 [15–25] mins for CMB, p = 0.004). Block performance properties did not differ between the groups. The only complication observed was vascular puncture with an incidence of 28% in Group CMB.

Conclusions

Lateral approach costoclavicular technique provides fastest block onset than the other techniques. Considering the success and safety profile, this technique stands as a good alternative in clinical practice.

Trial registration

This study is prospectively registered to clinicaltrials.gov on 20/02/2022 (NCT05260736).
Clinician care priorities and practices in the fourth trimester: perspective from a California survey
Authors: Guendelman Sylvia , Wang Serena Xinzi , Lahiff Maureen , Lurvey Lawrence , Miller Hayley E.
Published: July 2024

Background

Professional societies such as the American College of Obstetricians and Gynecologists (ACOG) promote the idea that postpartum care is an ongoing process where there is adequate opportunity to provide services and support. Nonetheless, in practice, the guidelines ask clinicians to perform more clinical responsibilities than they might be able to do with limited time and resources.

Methods

We conducted an online survey among practicing obstetric clinicians (obstetrician/gynecologists (OB/GYNs), midwives, and family medicine doctors) in California about their priorities and care practices for the first postpartum visit and explored how they prioritize multiple clinical responsibilities within existing time and resources. Between September 2023 and February 2024, 174 out of 229 eligible participants completed the survey, a 76% response rate. From a list of care components, we used descriptive statistics to identify those that were highly prioritized by most clinicians and those that were considered a priority by very few and examined the alignment between prioritized components and recommended care practices.

Results

Clinicians were highly invested in the care components that they rated as most important, indicating that they always check these components or assess them when they perceive patient need. Depression and anxiety, breast health/breast feeding issues, vaginal birth complications and family planning counseling were highly ranked components by all clinicians. In contrast, clinicians more often did not assess those care components that infrequently ranked highly among the priority listing, consisting mainly of social drivers of health such as screening and counseling for intimate partner violence, working conditions and food/housing insecurity. In both instances, we found little discordance between priorities and care practices. However, OB/GYNs and midwives differed in some care components that they prioritized highly.

Conclusions

While there is growing understanding of how important professional society recommendations are for maternal-infant health, clinicians face barriers completing all recommendations, especially those components related to social drivers of health. However, what the clinicians do prioritize highly, they are likely to perform. Now that Medi-Cal (Medicaid) insurance is available in California for up to 12 months postpartum, there is a need to understand what care clinicians provide and what gaps remain.
An online evidence-based dictionary of common adverse events of antidepressants: a new tool to empower patients and clinicians in their shared decision-making process
Authors: Hong James S. W. , Ostinelli Edoardo G. , Kamvar Roya , Smith Katharine A. , Walsh Annabel E. L. , Kabir Thomas , Tomlinson Anneka , Cipriani Andrea
Published: July 2024

Background

Adverse events (AEs) are commonly reported in clinical studies using the Medical Dictionary for Regulatory Activities (MedDRA), an international standard for drug safety monitoring. However, the technical language of MedDRA makes it challenging for patients and clinicians to share understanding and therefore to make shared decisions about medical interventions. In this project, people with lived experience of depression and antidepressant treatment worked with clinicians and researchers to co-design an online dictionary of AEs associated with antidepressants, taking into account its ease of use and applicability to real-world settings.

Methods

Through a pre-defined literature search, we identified MedDRA-coded AEs from randomised controlled trials of antidepressants used in the treatment of depression. In collaboration with the McPin Foundation, four co-design workshops with a lived experience advisory panel (LEAP) and one independent focus group (FG) were conducted to produce user-friendly translations of AE terms. Guiding principles for translation were co-designed with McPin/LEAP members and defined before the finalisation of Clinical Codes (CCs, or non-technical terms to represent specific AE concepts). FG results were thematically analysed using the Framework Method.

Results

Starting from 522 trials identified by the search, 736 MedDRA-coded AE terms were translated into 187 CCs, which balanced key factors identified as important to the LEAP and FG (namely, breadth, specificity, generalisability, patient-understandability and acceptability). Work with the LEAP showed that a user-friendly language of AEs should aim to mitigate stigma, acknowledge the multiple levels of comprehension in ‘lay’ language and balance the need for semantic accuracy with user-friendliness. Guided by these principles, an online dictionary of AEs was co-designed and made freely available (https://thesymptomglossary.com). The digital tool was perceived by the LEAP and FG as a resource which could feasibly improve antidepressant treatment by facilitating the accurate, meaningful expression of preferences about potential harms through a shared decision-making process.

Conclusions

This dictionary was developed in English around AEs from antidepressants in depression but it can be adapted to different languages and cultural contexts, and can also become a model for other interventions and disorders (i.e., antipsychotics in schizophrenia). Co-designed digital resources may improve the patient experience by helping to deliver personalised information on potential benefits and harms in an evidence-based, preference-sensitive way.
Brain structural and functional abnormalities in affective network are associated with anxious depression
Authors: Juan Qiao , Shiwan Tao , Yurong Sun , Jiabo Shi , Yu Chen , Shui Tian , Zhijian Yao , Qing Lu
Published: July 2024

Background

Anxious depression (AD) is a common subtype of major depressive disorder (MDD). Neuroimaging studies of AD have revealed inconsistent and heterogeneous brain alterations with the use of single-model methods. Therefore, it is necessary to explore the pathogenesis of AD using multi-model imaging analyses to obtain more homogeneous and robust results.

Methods

One hundred and eighty-two patients with MDD and 64 matched healthy controls (HCs) were recruited. Voxel-based morphometry (VBM) was used to estimate the gray matter volume (GMV) of all subjects. The GMV differences between the AD and non-anxious depression (NAD) participants were used as regions of interest (ROIs) for subsequent resting state functional connectivity (rs-FC) analyses. Correlation analysis was used to evaluate the associations between clinical symptoms and abnormal function in specific brain areas.

Results

Decreased GMV in the medial frontal gyrus (MFG) and the superior frontal gyrus (SFG) was observed in the AD group compared to the NAD group. Taking the MFG and SFG as ROIs, the rs-FC analysis revealed decreased FC between the left SFG and left temporal pole and between the left SFG and right MFG in the AD group compared to the NAD group. Finally, the FC between the left SFG and left temporal pole was negatively correlated with HAMD-17 scores in the AD group.

Conclusion

By combining the GMV and rs-FC models, this study revealed that structural and functional disruption of the affective network may be an important pathophysiology underlying AD. The structural impairment may serve as the foundation of the functional impairment.
Is routine antibiotic prophylaxis warranted in dental implant surgery to prevent early implant failure? – a systematic review
Authors: Momand Palwasha , Naimi-Akbar Aron , Hultin Margareta , Lund Bodil , Götrick Bengt
Published: July 2024

Background

The question of whether antibiotic prophylaxis should be administered routinely for dental implant surgery is unresolved. Despite the lack of conclusive supportive evidence, antibiotics are often administered to reduce the risk of infection, which could lead to early implant failure. Increasing antibiotic resistance is a major concern and it is therefore important to reduce the overall use of antibiotics, including in dentistry. The aim of the present systematic review and meta-analysis was to evaluate the efficacy of preoperative antibiotics in preventing early implant failure, in overall healthy patients undergoing dental implant surgery.

Methods

An electronic search was undertaken of PubMed (Medline), Web of Science and the Cochrane Library up to October 1st, 2023, to identify randomized clinical trials (RCTs). All RCTs comparing antibiotic prophylaxis with no antibiotics/placebo in overall healthy patients receiving dental implants were included. The primary outcome was patients with early implant failure. Risk of bias was assessed, data were extracted, a meta-analysis was done, and GRADE certainty-of-evidence ratings were determined. The risk ratio (RR), the risk difference (RD) and 95% confidence intervals (CI) were estimated.

Results

After removal of duplicates, 1086 abstracts were screened, and 17 articles were reviewed in full text. Seven RCTs with moderate or low risk of bias and with a total of 1859 patients and 3014 implants were included in the meta-analysis. With reference to early implant failure at patient level, the meta-analysis failed to disclose any statistically significant difference (RR: 0.66, 95% CI: 0.30-1.47) between antibiotic prophylaxis and a placebo. The risk difference was -0.007 (95% CI: -0.035-0.020) leading to a number needed to treat (NNT) of 143.

Conclusion

Antibiotic prophylaxis for dental implant surgery does not seem to have any substantial effect on early implant failure (
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). The results do not support routine antibiotic prophylaxis for dental implant surgery.
Impact of early palliative care intervention in autologous bone marrow transplantation: feasibility of a multicentric study
Authors: Argüello-Marina María , Callejas-Charavía Marta , Merchán-Muñoz Beatriz , Gainza-Miranda Daniel , Rico-Zampetti Agustina , Pérez-Maganto Raquel , Ruiz-Ares Gustavo , García-Ramírez Patricia , de Miguel-Llorente Dunia , García-Suárez Julio
Published: July 2024

Introduction

This prospective multicentre study evaluates the impact of Palliative Care Unit (PCU) intervention (Experimental Group, EG), during autologous hematopoietic stem cell transplantation (AHSCT) on quality of life (QoL), symptom control and healthcare resource use compared to standard practice (Control Group, CG). We used validated scales on Days 0 (stem cell infusion), + 7 (bone marrow aplasia, acute symptoms) and + 21 (aplasia recovery).

Results

In 40 patients (20 EG/ 20 CG: 45%/25% female, median age 57.5/59), QoL differed significantly at Day + 7 (EG: median 0.50; CG: -63.00; p < 0.001) and Day + 21 (EG: -2.00; CG: -129.00; p < 0.001). On Day 0, mean FACT-BMT scores were CG/EG: 131/ 89.35, reflecting the pre-transplant intervention of the PCU in EG patients. For pain (EG median 0.00, CG median 2.50; p = 0.01), 45% EG patients used opioids on day 0 (mean 38.5 mg morphine/day/patient). Reduced pain control impacted nutritional support (parenteral nutrition 45% CG, 5% EG; p = 0.08). Hospitalisation duration was longer in CG (median 18.5; EG median 13.00; p < 0.001). Despite the short follow-up and small sample size, PCU and HD collaboration improves QoL and symptom management during acute AHSCT, evident through pain control, analgesia management, reduced parenteral nutrition need and shorter hospital stays.
Strategies to strengthen the resilience of primary health care in the COVID-19 pandemic: a scoping review
Authors: Mosadeghrad Ali Mohammad , Afshari Mahnaz , Isfahani Parvaneh , Ezzati Farahnaz , Abbasi Mahdi , Farahani Shahrzad Akhavan , Zahmatkesh Maryam , Eslambolchi Leila
Published: July 2024

Background

Primary Health Care (PHC) systems are pivotal in delivering essential health services during crises, as demonstrated during the COVID-19 pandemic. With varied global strategies to reinforce PHC systems, this scoping review consolidates these efforts, identifying and categorizing key resilience-building strategies.

Methods

Adopting Arksey and O'Malley's scoping review framework, this study synthesized literature across five databases and Google Scholar, encompassing studies up to December 31st, 2022. We focused on English and Persian studies that addressed interventions to strengthen PHC amidst COVID-19. Data were analyzed through thematic framework analysis employing MAXQDA 10 software.

Results

Our review encapsulated 167 studies from 48 countries, revealing 194 interventions to strengthen PHC resilience, categorized into governance and leadership, financing, workforce, infrastructures, information systems, and service delivery. Notable strategies included telemedicine, workforce training, psychological support, and enhanced health information systems. The diversity of the interventions reflects a robust global response, emphasizing the adaptability of strategies across different health systems.

Conclusions

The study underscored the need for well-resourced, managed, and adaptable PHC systems, capable of maintaining continuity in health services during emergencies. The identified interventions suggested a roadmap for integrating resilience into PHC, essential for global health security. This collective knowledge offered a strategic framework to enhance PHC systems' readiness for future health challenges, contributing to the overall sustainability and effectiveness of global health systems.
Acute radiation skin injury in stage III-IV head and neck cancer: scale correlates and predictive model
Authors: Zhou Zihan , Lin Junjian , Wang Ying , Chen Yunhao , Zhang Yang , Ding Xingchen , Xu Benhua
Published: July 2024

Purpose

Active radiation skin injury (ARSI) has the highest incidence of acute adverse reactions caused by radiotherapy (RT) in patients with head and neck cancer (HNC). This study aimed to screen risk factors that can facilitate the identification of HNC patients at high risk of ARSI.

Methods

Data from 255 stage III-IV HNC patients who underwent intensity-modulated radiation therapy (IMRT) were collected. The data from our medical records, including clinical characteristics and hematological indices before RT, were retrospectively collected and arranged. The Common Terminology Criteria for Adverse Events Criteria (CTCAE), Radiation Therapy Oncology Group Criteria (RTOG), World Health Organization Criteria (WHO), Oncology Nursing Society (ONS), Acute Radiation Dermatitis Graduation Scale, Douglas & Fowler and Radiation Dermatitis Severity Scale (RDSS) were used to assess ARSI. Of these, CTCAE was used for further analysis. Binary logistic regression analyses were used to identity risk factors. To establish the correction between each risk factor and the ARSI score, the odds ratio (OR) and 95% confidence interval (CI) were computed.

Results

The assessment results of the CTCAE with RTOG, WHO, ONS, Graduation Scale, Douglas & Fowler and RDSS have good consistency. After radiotherapy, 18.4% of patients had at least 3 (3 +) grade ARSI. Multivariate logistic regression analysis revealed that the KPS score, blood glucose level, white blood cell count, and plasma free thyroxine (FT4) concentration were independent risk factors for 3 + grade ARSI. A nomogram was constructed on the basis of these risk factors, which demonstrated good predictive power according to the area under the ROC curve (AUC). The satisfactory consistency and clinical efficacy of the nomogram were confirmed by calibration curves and decision curve analysis (DCA).

Conclusion

A low KPS score, high blood glucose level, high white blood cell count, and high thyroid hormone prior to radiotherapy for stage III-IV HNC are independent risk factors for grade 3 + RSI.
Aptamer-functionalized triptolide with release controllability as a promising targeted therapy against triple-negative breast cancer
Authors: Chen Yao , Yang Jirui , Wang Chuanqi , Wang Tianbao , Zeng Yingjie , Li Xiao , Zuo Yi , Chen Hongyu , Zhang Chaozheng , Cao Yuening , Sun Chen , Wang Maolin , Cao Xiujun , Ge Xian , Liu Yilan , Zhang Ge , Deng Yun , Peng Cheng , Lu Aiping , Lu Jun
Published: July 2024

Targeted delivery and precise release of toxins is a prospective strategy for the treatment of triple-negative breast cancer (TNBC), yet the flexibility to incorporate both properties simultaneously remains tremendously challenging in the X-drug conjugate fields. As critical components in conjugates, linkers could flourish in achieving optimal functionalities. Here, we pioneered a pH-hypersensitive tumor-targeting aptamer AS1411-triptolide conjugate (AS-TP) to achieve smart release of the toxin and targeted therapy against TNBC. The multifunctional acetal ester linker in the AS-TP site-specifically blocked triptolide toxicity, quantitatively sustained aptamer targeting, and ensured the circulating stability. Furthermore, the aptamer modification endowed triptolide with favorable water solubility and bioavailability and facilitated endocytosis of conjugated triptolide by TNBC cells in a nucleolin-dependent manner. The integrated superiorities of AS-TP promoted the preferential intra-tumor triptolide accumulation in xenografted TNBC mice and triggered the in-situ triptolide release in the weakly acidic tumor microenvironment, manifesting striking anti-TNBC efficacy and virtually eliminated toxic effects beyond clinical drugs. This study illustrated the therapeutic potential of AS-TP against TNBC and proposed a promising concept for the development of nucleic acid-based targeted anticancer drugs.
Association between the triglyceride-glucose (TyG) index and stroke risk in Chinese normal-weight adults: a population-based study
Authors: Wu Man , Li Chaoyang , Yu Yiqing , Zeng Lijuan , Qiu Yufei , Liu Jiali , Yang Fen , Han Yangyang
Published: July 2024

Background

Identifying high-risk populations and promoting stroke prevention measures can be achieved through studies on stroke and its risk factors. As a new alternative indicator of insulin resistance (IR), the triglyceride glucose (TyG) index may potentially increase stroke risk. However, the evidence confirming this association is inadequate and inconsistent, possibly due to variations in stroke assessment criteria or characteristics of the study populations. This study aims to evaluate the association between the TyG index and stroke risk level among individuals with normal-weight.

Methods

A total of 30,895 participants aged ≥ 40 years with normal-weight were enrolled in this study. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Normal-weight was described as a body mass index (BMI) of 18.5-<24.0 kg/m2. Stroke risk was assessed by the Stroke Risk Assessment Scale, developed by the China National Stroke Screening and Prevention Project. To evaluate the associations between the TyG index and stroke risk level, multivariate logistic regression models were employed.

Results

Results showed that when the TyG index was considered as a continuous variable, each one unit increase in the TyG index was associated with a significantly higher risk of stroke [Moderate-risk (OR, 2.15; 95% CI, 2.03–2.28; P<0.001); High-risk (OR, 3.83; 95% CI, 3.57–4.10; P<0.001)]. Compared with Q1 of the TyG index, Q4 was significantly associated with moderate stroke risk (OR, 2.73; 95% CI, 2.50–2.99; P<0.001) and high stroke risk (OR, 5.39; 95% CI, 4.83–6.01; P<0.001). The continuous TyG index was an important risk factor for high stroke risk in the metabolically obese, normal-weight (MONW) individuals (OR, 3.44;95% CI, 2.92–4.06; P < 0.001). In the MONW individuals, when Q1 was used as a reference, participants in Q4 (OR, 5.33; 95% CI, 4.19–6.78; P < 0.001) was significantly associated with high stroke risk. Subgroup analysis showed significant interaction in the age and sex subgroups in the overall population (Pinteraction <0.001).

Conclusion

The risk of stroke is increased with the TyG index among Chinese adults of normal weight; hence, the index may be an important indicator for identifying high-risk stroke populations among individuals with normal body weight.
Tree-growth synchrony index, an effective indicator of historical climatic extremes
Authors: Jia Hengfeng , Zheng Jiacheng , Yang Jing , Lyu Lixin , Dong Yuntao , Fang Ouya
Published: July 2024

Background

Tree rings play an important role in reconstructing past climate. Growth differences among individual trees due to microclimatic conditions and local disturbances are averaged in developing tree-ring chronologies. Here, we addressed the problem of averaging by investigating growth synchrony in individual trees. We used tree-ring data of 1046 juniper trees from 32 sites on the Tibetan Plateau and 538 pine trees from 20 sites in the subtropical region of eastern China and calculated the tree-growth synchrony index (TGS).

Results

Our results showed that both the TGS index and tree-ring index could be indicators of interannual variation of climatic factors. The TGS index identified 20% more climatic extremes than tree-ring index over the last 50 years that high synchrony indicates extreme climate forcing in controlling forest growth.

Conclusions

The TGS index can identify extreme climatic events effectively than tree-ring index. This study provides a novel perspective for climate reconstruction, especially in the realm of tree growth response to extreme climate. Our findings contribute to understanding of the spatiotemporal dynamics and the causes of historical climate extremes and provide guidance for protecting trees from climate extremes in the future.
Can exercise benefits be harnessed with drugs? A new way to combat neurodegenerative diseases by boosting neurogenesis
Authors: Zhao Renqing
Published: July 2024

Adult hippocampal neurogenesis (AHN) is affected by multiple factors, such as enriched environment, exercise, ageing, and neurodegenerative disorders. Neurodegenerative disorders can impair AHN, leading to progressive neuronal loss and cognitive decline. Compelling evidence suggests that individuals engaged in regular exercise exhibit higher production of proteins that are essential for AHN and memory. Interestingly, specific molecules that mediate the effects of exercise have shown effectiveness in promoting AHN and cognition in different transgenic animal models. Despite these advancements, the precise mechanisms by which exercise mimetics induce AHN remain partially understood. Recently, some novel exercise molecules have been tested and the underlying mechanisms have been proposed, involving intercommunications between multiple organs such as muscle-brain crosstalk, liver-brain crosstalk, and gut-brain crosstalk. In this review, we will discuss the current evidence regarding the effects and potential mechanisms of exercise mimetics on AHN and cognition in various neurological disorders. Opportunities, challenges, and future directions in this research field are also discussed.
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Authors: Réginault Thomas , Martinez Alejos Roberto , Coueron Roxane , Burle Jean-françois , Boyer Alexandre , Frison Eric , Vargas Frédéric
Published: July 2024

Background

Inspiratory muscle training (IMT) is well-established as a safe option for combating inspiratory muscles weakness in the intensive care setting. It could improve inspiratory muscle strength and decrease weaning duration but a lack of knowledge on the optimal training regimen raise to inconsistent results. We made the hypothesis that an innovative mixed intensity program for both endurance and strength improvement could be more effective. We conducted a multicentre randomised controlled parallel trial comparing the impacts of three IMT protocols (low, high, and mixed intensity) on inspiratory muscle strength and endurance among difficult-to-wean patients.

Methods

Ninety-two patients were randomly assigned to three groups with different training programs, where each performed an IMT program twice daily, 7 days per week, from inclusion until successful extubation or 30 days. The primary outcome was maximal inspiratory pressure (MIP) increase. Secondary outcomes included peak pressure (Ppk) increase as an endurance marker, mechanical ventilation (MV) duration, ICU length of stay, weaning success defined by a 2-day ventilator-free after extubation, reintubation rate and safety.

Results

MIP increases were 10.8 ± 11.9 cmH2O, 4.5 ± 14.8 cmH2O, and 6.7 ± 14.5 cmH2O for the mixed intensity (MI), low intensity (LI), and high intensity (HI) groups, respectively. There was a non-statistically difference between the MI and LI groups (mean adjusted difference: 6.59, 97.5% CI [− 14.36; 1.18], p = 0.056); there was no difference between the MI and HI groups (mean adjusted difference: − 3.52, 97.5% CI [− 11.57; 4.53], p = 0.321). No significant differences in Ppk increase were observed among the three groups. Weaning success rate observed in MI, HI and LI group were 83.7% [95% CI 69.3; 93.2], 82.6% [95% CI 61.2; 95.0] and 73.9% [95% CI 51.6; 89.8], respectively. MV duration, ICU length of stay and reintubation rate had similar values. Over 629 IMT sessions, six adverse events including four spontaneously reversible bradycardia in LI group were possibly related to the study.

Conclusions

Among difficult-to-wean patients receiving invasive MV, no statistically difference was observed in strength and endurance progression across three different IMT programs. IMT appears to be feasible in usual cares, but some serious adverse events such as bradycardia could motivate further research on the specific impact on cardiac system.

Trial registration Clinicaltrials.gov identifier: NCT02855619. Registered 28 September 2014