bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute management of the patient with Diarrhoea
Authors:   Royal Hampshire County Hospital Romsey Road Winchester, Colleypriest B , Gordon H ,   Royal Hampshire County Hospital Romsey Road Winchester
Published: June 2021

Diarrhoea is a relatively common symptom in patients presenting to the acute medical take. The differential diagnosis is wide, although the commonest causes are infection, inflammatory bowel disease and motility disturbances. This article aims to summarise an approach which doctors working at the front door may use to enable rapid diagnosis of the cause of diarrhoea, along with management strategies for its treatment.
Society for Acute Medicine Autumn Meeting
Authors:   Royal Hampshire County Hospital Romsey Road, Winchester, Chadwick B
Published: June 2021

The autumn meeting of the Society for Acute Medicine took us to the spectacular city of Edinburgh. More than 150 delegates attended this, the tenth meeting of the Society, by far the largest attendance to-date, and a clear ref lection of the rapid expansion of this new sub-specialty. We were hosted by the Royal College of Physicians of Edinburgh, in their grand building on Queen Street, and were made to feel welcome by all the staff there. A special mention must go to the immaculately turned-out doorman who helped me find my way from the Royal College to my accommodation at a nearby hotel.
The management of acute pericarditis
Authors:   Fremantle Cardiac Unit, Fremantle Hospital, Perth, W.A. 6160, Australia, Wells Tim , Curzen NP ,   Wessex Cardiac Unit, Southampton University Hospital, Southampton
Published: June 2021

Acute pericarditis is usually a benign self-limiting condition, often of unexplained or viral aetiology, involving inflammation of the pericardial layers. It is often part of the differential diagnosis in patients admitted with acute chest pain and can be confused with acute myocardial infarction, acute pulmonary embolism and pleurisy. Occasionally it can result in cardiac tamponade and, if associated with myocarditis, in heart failure. This article sets out how to diagnose acute pericarditis, the common underlying causes, the possible treatment options and outcomes.
Myxoedema Coma
Authors:   Diabetes & Endocrinology, North Hampshire Hospital, Basingstoke, Hampshire, Turner Ben
Published: June 2021

Myxoedema coma is a rare and extreme presentation of hypothyroidism. It has a poor prognosis due to multisystem decompensation, and demands prompt but careful management in a high-dependency / intensive care setting. Early recognition of hypercapnia, hyponatraemia, and sepsis are especially important. Treatment should begin on suspicion of the diagnosis and can be life-saving. Intravenous thyroid hormone replacement is required at first, with steroid cover, although the optimum dose regimen remains unclear.
Asymptomatic Hyponatraemia on the Acute Medical Unit
Authors:   Southampton University Hospitals NHS Trust Tremona Road, Southampton, Patel M
Published: June 2021

Hyponatraemia is defined as a serum sodium concentration of 135 mmol/L or less. It is the most common electrolyte abnormality, and can be associated with significant morbidity and mortality.1 There are numerous causes and a systematic approach to the initial investigation and management is required. Clinical assessment should start with evaluation of the patient’s degree of hydration, with the measurements of serum and urine osmolality and urinary sodium concentration being the key biochemical investigations. A recent article in this journal highlighted the challenges associated with acute symptomatic hyponatraemia; this article concentrates on the more common scenario of the patient with asymptomatic hyponatraemia.
A Response to the Viewpoint Paper in Vol 6 issue 2
Authors:   Emergency Department, United Bristol Healthcare Trust, Bristol, BS2 8HW, Craig Michelle , Benger Jonathan ,   Emergency Department, United Bristol Healthcare Trust, Bristol, BS2 8HW
Published: June 2021

We read with interest the “viewpoint” by Sarbjit Clare and colleagues recommending that specialist registrars in acute medicine should receive patients in the resuscitation room.1 We agree that this is a valuable training experience, but question some of the assumptions made.
The Management of Community Acquired Pneumonia
Authors:   Manchester Royal Infirmary Oxford Road Manchester, Syed Tania , Woodhead Mark ,   Manchester Royal Infirmary
Published: June 2021

Community acquired pneumonia (CAP) is a common cause of hospital admission. The first 24–48 hours are crucial in the correct diagnosis and management of CAP. In this article we highlight the pitfalls in diagnosis and the important management steps. The correct assessment of severity with CURB65 scoring, proper supportive measures and appropriate antibiotics are key to effective treatment of CAP.
Spontaneous Pneumomediastinum After Oral Ingestion of Ecstasy
Authors:   Bishop Auckland General Hospital, Cockton Hill Road, Bishop, Moorchilot Ravisankar , Orr Peter K ,   Bishop Auckland General Hospital, Cockton Hill Road, Bishop, Prescott Richard WG ,   Bishop Auckland General Hospital, Cockton Hill Road, Bishop
Published: June 2021

We describe a 23 year old male who presented with sudden onset of facial swelling, nasal tone of voice and shortness of breath after taking eight tablets of ecstasy. He was found to have surgical emphysema and pneumomediastinum. Though spontaneous pneumomediastinum is well known in inhalation drug users who try to enhance alveolar resorbtion with repeated Valsalva manouvre, it is rather unusual to see it after oral ingestion of ecstasy. The probable causative event is the prolonged and excessive physical exertion involved in dancing at a “rave”. Acute physicians should be aware of the association and of its usually benign nature.
The Society for Acute Medicine (UK) Acute Medicine Training Survey 2007
Authors:   Chelsea & Westminster Hospital, 369 Fulham Road, London, Skene Hannah , Ward David K ,   King George Hospital Barking, Havering and Redbridge Hospitals NHS Trust Essex
Published: June 2021

An online survey of training in Acute Medicine was conducted to assemble a true picture of the current situation in the UK. The specialty is flourishing, with over 60 trainees having predicted CCT dates in Acute Medicine in 2010 and 2011 alone. 128 respondents highlighted a multitude of issues, including the need for improvements in management and special skills training and part time opportunities. We have used the results of this survey to suggest action points for Deaneries, Training Programme Directors, the Society for Acute Medicine (UK) and those involved in workforce planning.
Dysphagia: Aspects of assessment and management for the Acute Physician
Authors:   Gastroenterology, Southampton University Hospitals NHS Trust, Southampton, Stacey Bernard , Ahmed Adil ,   Gastroenterology, Royal Hampshire County Hospital, Winchester
Published: June 2021

The term Dysphagia originates from a Greek word meaning disordered eating. It is defined as difficulty in swallowing. Dysphagia should not be confused with globus senstation, a feeling of having a lump in the throat, which is unrelated to swallowing and occurs without impaired transit (see below). Although odynophagia (painful swallowing) and phagophobia (fear of swallowing) are symptoms that may be associated with dysphagia it is important to distinguish this in the history…
Assessment of clinical risk in the out of hours hospital prior to the introduction of Hospital at Night
Authors:   NHS Forth Valley and National Clinical Lead, Whole Systems Patient Flow Programme, Scottish Government, Beckett Daniel J , Gordon CF , Paterson R ,   Royal Infirmary of Edinburgh, Little France, Old Dalkeith Road, Edinburgh, Chalkley S ,   Chelsea and Westminster Hospital, 369 Fulham Road, London, MacLeod DC ,   Western General Hospital, Crewe Road South, Edinburgh, Bell Derek ,   Chelsea and Westminster Hospital Imperial College London Fulham Road London
Published: June 2021

Overnight medical cover in hospital is less than during daylight hours. We aimed to quantify the numbers of patients deteriorating overnight and their clinical outcome. Data was collected in real time on use of the Standardised Early Warning Score (SEWS), ‘time to doctor’, seniority of medical review and clinical outcome. 136 incidents of clinical concern were noted on the general wards with a median response time of 5 minutes for SEWS>4 and 10 minutes if SEWS<4. 159 incidents were recorded in critical care. There was significant inter-speciality variation in median response times and seniority of responding staff, particularly within critical care, which recorded the slowest times across the hospital. This will be reassessed following the establishment of Hospital at Night.
Recent advances in the Lefschetz fixed point theory for multivalued mappings
Authors: GÓRNIEWICZ Lech
Published: June 2021

In 1923 S. Lefschetz proved the famous fixed point theorem which is now known as the Lefschetz fixed point theorem (comp. [5], [9], [20], [21]. The multivalued case was considered for the first time in 1946 by S. Eilenberg and D. Montgomery ([10]). They proved the Lefschetz fixed point theorem for acyclic mappings of compact ANR-spaces (absolute neighborhood retracts (see [4] or [13]) using Vietoris mapping theorem (see [4], [13], [16]) as the main tool. In 1970 Eilenberg, Montgomery's result was generalized for acyclic mappings of complete ANR-s (see [17]). Next, a class of admissible multivalued mappings was introduced ([13] or [16]).

Note that the class of admissible mappings is quite large and contains as a special case not only acyclic mappings but also infinite compositions of acyclic mappings. For this class of multivalued mappings several versions of the Lefschetz fixed point theorem were proved (comp. [11], [13]-15], [18], [19], [27]). In 1982 G. Skordev and W. Siegberg ([26]) introduced the class of multivalued mappings so-called now (1 − n)-acyclic mappings. Note that the class (1−n)-acyclic mappings contain as a special case n-valued mappings considered in [6], [12], [28]. We recommend [8] for the most important results connected with (1 − n)-acyclic mappings. Finally, the Lefschetz fixed point theorem was considered for spheric mappings (comp. [3], [2], [7], [23]) and for random multivalued mappings (comp. [1], [2], [13]). Let us remark that the main classes of spaces for which the Lefschetz fixed point theorem was formulated are the class of ANR-spaces ([4]) and MANR-spaces (multi absolute neighborhood retracts (see [27]). The aim of this paper is to recall the most important results concerning the Lefschetz fixed point theorem for multivalued mappings and to prove new versions of this theorem mainly for AANR-spaces (approximative absolute neighborhood retracts (see [4] or [13]) and for MANR-s. We believe that this article will be useful for analysts applying topological fixed point theory for multivalued mappings in nonlinear analysis, especially in differential inclusions.
Pregnancy and public road accident: Frequency, socio-demographic and materno-fetal prognostics at the Prefectoral Hospital of Siguiri, Guinea
Authors: Boubacar Siddi Diallo  , Boubacar Alpha Diallo  , Ibrahima  Conte  , Oumar Diawara  , Maurice Koivogui  , Abdourahmane Diallo  , Ibrahima Sory Balde  , Telly Sy  , Yolande Hyjazi  , Namory Keita
Published: June 2021

Objectives: To calculate the frequency of road accidents among pregnant women, to describe the epidemiological profile and to establish the maternal and fetal prognosis at the prefectural hospital of Siguiri. Methodology: this was a prospective study of a descriptive type lasting six (6) months from August 1, 2019 to January 31, 2020. It concerned all pregnant women victims of road accidents admitted to Siguiri prefectural hospital during the study period. All pregnant women who were victims of road accidents received at the hospital during the study period and who gave their consent were included. All pregnant victims of road accidents who did not give their consent were included and cases of trauma unrelated to the road accident. We conducted an exhaustive recruitment of all highway accident cases among pregnant women during the study period. The limitations or constraints of the study were the delay in the care of some pregnant women who first sought treatment from traditional healers. Results: The frequency of road accidents among pregnant women was 52.08% (n = 25) taking into account pregnant women victims of trauma (n = 48). The epidemiological profile was that of a woman in the age group 14-23 years and 24-33 years (44%), housewife (72%) and city dwellers (76%). The majority of pregnant women were received through a police requisition (68%) followed by themselves (24%). The predominant type of accident gear was two-wheeled (88 %) Pregnant women in the second trimester of pregnancy were the most affected (68%). The predominant bodily injuries were minor injuries (52%) followed by no injuries (simple contusion) (32%) and then serious injuries (poly trauma) (16%). The road accident had no impact on the pregnancy in (84%) followed by death in utero 12% then threat of premature delivery 4%. All pregnant women with minor injury or without injury (with a living fetus) received treatment with spasfon / salbutamol plus progesterone for 48 hours and delivery was directed to patients with death in utero. We recorded a maternal mortality rate of 12% and an in utero fetal death rate of 12%. Conclusion: Road accidents involving a pregnant woman are frequent in the prefecture of Siguiri, occurring in young women traveling on two-wheeled vehicles. Trauma and pregnancy management were multidisciplinary.
A case of myxofibrosarcoma located on the chest wall
Authors: Gizem Keçeci Özgür  , Ufuk Cagirici  , Tevfik İlker Akçam  , Alpaslan Cakan  , Banu Yaman
Published: June 2021

Myxofibrosarcoma is a variant of fibrosarcoma, a tumor consisting of malignant fibroblasts, exhibiting a variable myxoid stroma, pleomorphism and wide curved vascular pattern. The most common location site of the tumor is the extremities. Uncommonly it is located in the trunk, head and neck. Herein we present a very rare case of surgically treated chest-wall-myxofibrosarcoma.
Study of Antioxidant Property of the Tuber Extract of Habenaria Edgeworthii (Vrddhi) and its use in the green synthesis of Gold nanoparticles
Authors: Bag Braja Gopal , Barai Abir Chandan
Published: June 2021

The antioxidant activity of the tuber extract of Habenaria edgeworthii (commonly
known as Vrddhi) has been studied against a long lived 2,2-diphenylpicrylhydrazyl (DPPH) radical at room temperature. The phytochemicals present in the tuber extract have been utilized for the synthesis of stable gold nanoparticles at room temperature under very mild conditions. The synthesized gold nanoparticles were characterized by Surface Plasmon Resonance spectroscopy, High resolution transmission electron microscopy studies and a mechanism for the synthesis of stabilized gold nanoparticles has been proposed.
Study of Antioxidant Property of the Endosperm Extract of Borassus flabellifer (Taal) and its use in the green synthesis of Gold nanoparticles
Authors: Hasan Sk Nurul , Bag Braja Gopal
Published: June 2021

The antioxidant activity of the endosperm extract of Borassus flabellifer (commonly known as Taal) has been studied against a long lived 2,2-diphenylpicrylhydrazyl (DPPH) radical at room temperature. The phytochemicals present in the endosperm extract have been utilized for the synthesis of stable gold nanoparticles at room temperature under very mild conditions. The synthesized gold nanoparticles were characterized by Surface Plasmon
Resonance spectroscopy, High resolution transmission electron microscopy, X-Ray diffraction and FTIR studies and a mechanism for the synthesis of stabilized gold
nanoparticles has been proposed.
Synthesis of 6-hydroxy-N-(6-methylpyridin-2-yl) naphthalene-2- carboxamide and its alkoxy analogues
Authors: Bag Braja G. , Ghorai Subrata , Panja Saikat K. , Dinda Shaishab K. , Paul Koushik
Published: June 2021

6-hydroxy-N-(6-methylpyridin-2-yl)naphthalene-2- carboxamide and its alkoxy analogues bearing long alkyl chains have been synthesized using 6-hydroxy-2-naphthoic
acid and 2-amino-6-picoline. The facile synthetic scheme reported here using conventional laboratory reagents opens up a new strategy for the generation of libraries of such
compounds in high yields. The H-bond donor acceptor groups along with the reactive 2-naphthol moiety present in the target compounds make them useful for their use in self-assembly and self-replication studies.
Terpenoids as Renewable Nano-Sized Building Blocks
Authors: Bag Braja Gopal , Barai Abir Chandan , Hasan Sk Nurul , Das Subhajit , Garai Chhabi , Ghorai Subrata , Panja Saikat Kumar
Published: June 2021

Terpenoids are a large and structurally group of natural products containing multiple five carbon containing isoprene units. Previously we have reported that irrespective of their acyclic or alicyclic nature, all the triterpenoids containing 30C’s have nano-metric lengths. In the current studies, detailed computations have been carried out with 120 naturally occurring mono- (C10), sesqui- (C15), di- (C20), sester- (C25), sesqua- (C35) and tetra- (C40) terpenoids using Gaussian 09 software with Gauss view 07 and molecular mechanics calculation using Serena software. The heat of formation and the calculated molecular lengths obtained by the two methods were compared. Interestingly, monoterpenoid to tetraterpenoid all the terpenoids (except three monoterpenoid and one sesqui-terpenoid) have molecular lengths above one nanometer making them useful as nano-sized building blocks.
The Impact of Organizational Culture and Principal Leadership on Teacher’s Performance
Authors: NURHAYATİ Nurhayati , KRİSTİAWAN Muhammad , PUSPİTA Yenny
Published: June 2021

The goal of this research is to evaluate the influence of school organizational culture and leadership on the success of teachers. This comprehensive analysis was done at Muara Sugihan State High School in the sub-district. The data collection method used a questionnaire administered to a sample of 59 teachers. The goal of this research is to evaluate the influence of school organizational culture and leadership on the success of teachers. This comprehensive analysis was done at Muara Sugihan State High School in the sub-district. The data were collected using a questionnaire administered to a sample of 59 teachers. The findings of this analysis find 1) there is a positive and significant impact of the school organizational culture on the performance of teachers in the Muara Sugihan District; 2) there is a positive and significant influence of the principal leadership on the performance of teachers in the Muara Sugihan District; 3) there is a positive impact on the success of teachers in the Muara Sugihan District between the ethos of the school community and the leadership of the principal. This paper provides different finding from other paper where the school tends to have good teacher's performance, they should have good organizational culture and principal leadership.
Develpoment of The Pandemic Anxiety Scale
Authors: ÖZALP Mehmet , DEMİR ÇELEBİ Çiğdem , EKSİ Halil
Published: June 2021

It is aimed to develop a valid and reliable measurement tool that will help to evaluate anxiety related to pandemic in this study. Quantitative research method is conducted in this study. For data analysis, it is collected in two stages from 627 individuals aged 18 and older who lives in various regions and provinces of Turkey. Both construct validity and criteria validity are used to ensure validity. For construct validity, confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) are conducted. Reliability of the tool is enabled by calculating Cronbach alpha internal consistency coefficient and item-total score correlation coefficients. As a result of the exploratory factor analysis, it is noticed that the Pandemic Anxiety Scale (PAS) explains 56.54% of the total variance, and the scale consists of 26 items gathered in four factors: contagion anxiety, somatic responses, psychosocial effects and dysfunctional beliefs. According to the confirmatory factor analysis, it can be said that the structure revealed in EFA has been confirmed. In the criteria validity analysis, it is concluded that PAS has a moderately positive relationship with the Anxiety Sensitivity Index-3 scale adapted to Turkish by Mantar (2008). In the internal consistency analysis conducted to find out the reliability of the scale and the result of the level on this scale is confirmed to be high. It is observed that item-total score correlation coefficients differ from .36 to .75. In consequence of validity and reliability analysis, it is realized that Pandemic Anxiety Scale is a valid and reliable measurement tool.
Suggestions on Education during the COVID-19 Pandemic Process
Authors: İÇEN Mustafa
Published: June 2021

COVID-19, which started in China in January 2020, spread almost all over the world in a short time and turned into a global pandemic. This pandemic also affected the education systems, and schools were closed in 194 countries from preschool to higher education at the beginning of April, and approximately 1.5 billion students were affected by this situation. In many countries of the world, face-to-face education was paused from preschool to higher education. It can be said that although this process has compelling effects for all children who are in social isolation, these effects can be much greater in children with disabilities and children who do not have a private space in their houses, physical and mental stimulations, materials to trigger their interests and curiosity, supportive parents, and a safe and affectionate environment. Additionally, the responsibilities of children to continue their learning during their stay at home due to distance education increase both children and their parents' anxiety and stress for this process. The aim of this study is to evaluate the effects and reflections of the pandemic on education and solution suggestions to the problems. The digital world has changed student roles as well as teacher-family roles. Children and young people benefit from digital education starting from pre-school period, which will contribute to the education benefit level of the term population.
First-year university students' perception of chemical bonding and bond energy
Authors: Aakre Iselin Grav , Persson Jonas R. , Lein Hilde Lea , Eggen Per-Odd
Published: June 2021

First-year university students’ knowledge and conceptual understanding of general chemistry has been investigated using a multiple-choice concept inventory (Chemical Concept Inventory 3.0/CCI 3.0) as a pre-test (n = 221) and a post-test (n = 90) in two first-semester chemistry courses. This paper discusses the students’ answers to two questions about bond energy. Student interviews (n = 7) were performed for further insight in the students’ thought processes and validation of the CCI questions. Although many students appeared to recall that breaking a chemical bond demands energy, most were not able to use this fact to reason about the heat released in a chemical reaction, and the alternative conception that bond breaking releases energy seemed deeply ingrained and prevalent among the students. For one of the questions, more students gave the correct answer on the pre-test than on the post-test. Student interviews indicated that some students’ failure to pick the correct alternative for this question might be influenced by use of the word “always” in the correct answer, which discouraged those students that find chemistry to be a subject full of exceptions.
Destructive care
Authors: Varfolomeeva Anna
Published: June 2021

There is a growing awareness of the essential similarities between care and maintenance notions in more-than-human settings. Whereas the concept of care is increasingly extended towards non-living organisms, research on maintenance and repair still focuses mainly on technologies and infrastructures. This article extends the realm of maintenance theorizing towards humans' caretaking activities and discusses the concepts' parallels. It focuses on the case study of Veps ethnic minority in Karelia, Northwestern Russia. Since the 18th century, Veps have been extracting rare ornamental stones: gabbro-diabase and raspberry quartzite. The article demonstrates that Veps workers engage in close bodily and material interactions with the mining industry. Whereas many of them enter into affective relations with the stone, their attitudes towards their bodies and health become estranged and detached. The article introduces the concept of "destructive care" to analyze the process of the workers' growing alienation from their bodily needs. Through the Veps' example, the article demonstrates that the logics of care and maintenance become entangled in the realm of human – material co-existence.
Captura de Langosta en Baja California y su relación con la Actividad Solar
Authors: Sierra-Figueredo Pablo , Hernández de la Torre Benigno , Vega-Velázquez Armando , Vega-Bolaños Armando
Published: June 2021

Es creciente el interés por conocer los vínculos entre el comportamiento de la Actividad Solar (AS) y del Clima Espacial con numerosos procesos de la biosfera y en particular, los relacionados con la extracción de especies marinas. En este trabajo se relacionó la serie de tiempo anual (1959-2018) de captura de langosta por varias cooperativas pesqueras a lo largo de la Península de Baja California, México, con los ciclos multianuales de la AS, con el objetivo de revelar si se cumple la hipótesis de asociación entre estas variables. La relación estadística y análisis espectral entre las dos series muestran un marcado sincronismo entre las series de tiempo y la presencia en los volúmenes de captura del período principal de 11 años de la AS. Se explica la posible conexión AS-clima-océano con la variabilidad pesquera del crustáceo. Teniendo en cuenta los volúmenes de captura de langosta y la importancia económica que ello constituye para la región, se considera un aspecto importante para su posible aplicación práctica y explotación de este conocimiento en el marco de la tendencia en los ecosistemas debido a la variabilidad climática.
Palabras claves: Clima Espacial, Clima, Producción Pesquera.
Analysis of the Digital Footprint of Orthopaedic Surgeons
Authors: Subhash Ajith K. , Sekimura Troy , Kajikawa Trent M. , Trikha Rishi , Hsiue Peter P. , Khoshbin Amir , Photopoulos Christos , Stavrakis Alexandra
Published: June 2021

Introduction:

Patients increasingly rely on Google search to guide their choice of healthcare providers. Despite this trend, there is limited literature systematically characterizing the online presence of orthopaedic surgeons. The goal of this study was to identify the information patients see after queries of Google search when selecting orthopaedic surgeon providers.

Methods:

The Physician Comparable downloadable file from the Centers for Medicare and Medicaid Services was deduplicated and filtered. A list of orthopaedic surgeons within the United States was generated, of which a randomized sample was taken and queried using a Google Custom Search. The results for each surgeon's first page were classified into the following categories: (1) hospital-controlled content website, (2) third-party health website, (3) social media website, (4) primary academic journals, or (5) other.

Results:

The most frequently returned website was third-party health websites (43.3%). Statistically significant differences were observed in the categories across multiple comparisons, including academic and nonacademic orthopaedic surgeons, male and female providers, and surgeons from different graduation years.

Discussion:

Most of the results were attributed to third-party websites demonstrating that orthopaedic surgeons do not have notable control over their digital footprint. Increased patient visibility of physician-controlled websites and an objective rating system for patients remain potential areas of growth.
Role of Research-based Learning on Graduates’ Career Prospects
Authors: Timiyo Adobi Jessica , Sriram Neelima
Published: June 2021

Education is still a leeway towards achieving individual’s personal growth as well as professional development. Further and Higher Education (FHE) are even more crucial in accelerating the achievement of these goals. Consequently, graduate students explore endless opportunities to enroll for postgraduate programs, hoping to gain financial independence, economic freedom, and improved standard of living after completion. Since graduate programs offer such tremendous career and life-changing opportunities, it is imperative to investigate if programs like the master’s in business administration are still relevant in today’s fast-moving business environment. This phenomenology study systematically utilizes underlying assumptions of research-based learning to assess a core aspect of universities’ MBA curriculum, that is writing a dissertation. It examines the value added by dissertation to graduates’ long-term career goals. Data for the study was obtained from fourteen MBA graduates through unstructured in-depth interviews. All the graduates currently work as full-time employees in their respective organisations, who were drawn from four main departments namely marketing, education, accounting and the IT industry. Our findings are thought provoking, yet compelling, in the sense that participants expressed mixed opinions concerning whether the dissertation prepared them for their current job roles. Most of them attributed their career successes to luck and hard work. Good communication and leadership skills also played major roles. Only few of them did acknowledge honing such skills while writing their dissertation during the research process. The implication of this research to stakeholders of higher education institutions, and policy makers, are also discussed.
A NOTE ON EXTENSIONS GENERATED BY CLOSED SETS
Authors: Ganster Maximilian
Published: June 2021

In a recent paper Abd El-Monsef et al. consider a certain topology on $2^X$ where $2^X$ is the family of all nonempty closed subsets of a given topological space $X$. Vnfortunately, several results in their paper are incorrect and so the purpose of this note is to correct, improve and expand these results. In addition, the main quesion in their paper turns out to have a quite simple answer.
Gestão de projetos com o LIFECYCLECANVAS® (LCC): uma aplicação em um órgão do poder legislativo
Authors: Sousa Breno Henrique Medeiros de , Medeiros Marcos Fernando Machado de
Published: June 2021

A administração pública desenvolve-se em um cenário cada vez mais dinâmico, e a demanda por serviços públicos de qualidade reforça a importância de ferramentas de reinvenção às mais diversas estruturas organizacionais. Nesse sentido, a gestão visual de projetos aparece como uma alternativa às práticas tradicionais para contribuir com o incremento dos resultados organizacionais. Este artigo tem por objetivo propor um modelo para simplificar e otimizar a gestão dos projetos estratégicos do poder legislativo do Rio Grande do Norte. Para subsidiar o trabalho, foi realizada uma pesquisa-ação aplicada de natureza qualitativa, através de observação participante e grupo focal. Os resultados obtidos demostraram a aderência do LifeCycleCanvas® (LCC) em relação à gestão do ciclo de vida de um projeto real. Além disso, também foi possível verificar a dinâmica e a gestão da mudança em todas as fases, sendo possível perceber os impactos que afetariam o projeto e promover ajustes. O estudo também gerou implicações gerenciais, como a viabilidade de replicação, com as devidas adaptações, do modelo proposto em outros projetos da Instituição, atuando como ferramenta auxiliar pela Assessoria de Planejamento e abrindo espaço para pesquisas futuras com novas abordagens.
Negócio baseado em projetos: o caso do instituto internacional de física
Authors: Brito Jéssica Vivianne da Cunha Silva de , Ribeiro Waldelino Duarte , Silva Rafael Rodrigues da , Medeiros Júnior Josué Vitor De , Sousa Neto Manoel Veras de
Published: June 2021

Este trabalho objetiva apresentar o processo de elaboração de planejamento estratégico do Instituto Internacional de Física (IIF) da Universidade Federal do Rio Grande do Norte (UFRN). Um aspecto inovador foi que o planejamento estratégico construído foi todo baseado no conceito de Negócio Baseado em Projetos (NBP), proposto por Veras (2017). O estudo desenvolveu-se sob uma perspectiva qualitativa com uso da observação participante. Verificou-se que a utilização do conceito de NBP possibilitou formular os projetos a partir do desdobramento dos objetivos estratégicos, com critérios de priorização e seleção, além de ter promovido o engajamento de todas as partes envolvidas na elaboração do planejamento. Este estudo contribui com a teoria à medida que desenvolve o conceito de NBP, o qual é pouco abordado na literatura nacional, e mostra a adoção prática de algumas ferramentas de gestão.
Big data analytics applied to health services: a literature review
Authors: Gomes Myller Augusto Santos , Silva Vander Luiz da , Kovaleski João Luiz , Pagani Regina Negri
Published: June 2021

O objetivo deste estudo é compreender os conceitos e a evolução da análise de big data aplicada aos serviços de saúde, considerando as atividades que envolvem o diagnóstico, tratamento e manejo do paciente. A revisão da literatura, consultando as bases de dados Science Direct, Scopus e Web of Science e empregando as palavras-chave health analytics e big data analytics sem restrições de tempo, encontrou trabalhos que abordam, especificamente, o uso de big data analytics no contexto da saúde, representados por exemplos e análises relacionadas. O tempo e a tomada de decisão aparecem como ações desenvolvidas tanto pela equipe de tecnologia da informação quanto pela equipe clínica, podendo considerar variáveis como custo, tempo, decisão e desempenho da estrutura funcional como os principais determinantes alinhados à estratégia corporativa. Este trabalho espera fomentar pesquisas sobre aspectos da saúde pública, além de considerar a preocupação com a sobrevivência das pessoas afetadas.
O PAPEL DO ECOSSISTEMA DE INOVAÇÃO PARA DESENVOLVER UMA AGRICULTURA INTELIGENTE
Authors: Leso Bernardo Henrique , Valle Enrique Daisy , Falcão Peruchi Diego
Published: June 2021

Dado o crescimento do desenvolvimento e adoção de tecnologias digitais no ecossistema do agronegócio, o qual representa um mercado em expansão, o presente estudo verifica a influência das novas tecnologias digitais no agronegócio e como os atores do ecossistema de inovação ajudam desenvolver e implementar as mesmas. Para isto foram feitas 18 entrevistas semiestruturadas com diferentes atores do ecossistema agrícola. Os resultados apontam que o processo de digitalização no setor ainda é lento, devido diferentes barreiras relacionadas à infraestrutura de rede, à falta de conhecimento e habilidades e à resistência à adoção de tecnologia por parte dos agricultores, principalmente produtores de pequeno e médio porte. Nesse contexto os atores do ecossistema detêm um papel fundamental: universidades com pesquisa de pontas que impactam no setor e empresas públicas e privadas promovendo o uso das tecnologias e sendo um elo entre os desenvolvedores das mesmas e o agricultor.
A teoria das Restrições aplicada no setor público: uma revisão da literatura
Authors: Santos Scheirla Teixeira , Pereira Tábata Fernandes , Santos Ana Carolina Oliveira
Published: June 2021

Considerando a importância da Teoria das Restrições para as organizações privadas, o objetivo deste estudo é realizar um levantamento na literatura, para identificar como a utilização dessa ferramenta impacta também nas instituições públicas. O método utilizado consiste em uma Revisão Sistemática da Literatura abrangendo as pesquisas, nacionais e internacionais, publicadas sobre o tema entre 2009 e 2019. O estudo contribui para a teoria com o resgate dos trabalhos que abordaram a metodologia nas especificidades do serviço público, sintetizando a evidência disponível na literatura. Como contribuição prática, o estudo apresenta um instrumento de diagnóstico pode auxiliar profissionais e pesquisadores no seu cotidiano de trabalho e aprimoramento das operações das instituições. Por fim, a contribuição para a sociedade, está na demonstração de possibilidade de adoção de um mecanismo de melhoria contínua para os processos e estratégias dos órgãos públicos, que por sua vez reflete no melhor atendimento aos anseios da sociedade.
História da Ciência em Livros Didáticos de Química Aprovados no PNLEM/2018
Authors: Silva Isabel Cristina Teixeira da , Goi Mara Elisângela Jappe
Published: June 2021

Pesquisas na área do Ensino de Ciências têm constatado que o livro didático exerce influência direta no ensinar e no apreender, sendo um dos principais balizadores no planejamento das aulas pelos educadores. Vários autores, por sua vez, defendem que a compreensão da História da Ciência contribui para aprendizagem dos conceitos científicos, entretanto ressaltam que a falta de fontes bibliográficas adequadas, atrelada à falta de formação específica são empecilhos a sua utilização em sala de aula. Nesse sentido, o presente trabalho busca investigar como a História da Ciência vem sendo apresentada nos livros didáticos de Química, de modo a auxiliar o professor em sua implantação no ensino e paralelamente apontar problemas e levantar questões relevantes para futuras adequações. Com esse intuito, realizou-se a análise das seis coleções de livros didáticos de Química (Manual do Professor), aprovadas pelo Programa Nacional do Livro Didático para o Ensino Médio (PNLEM/2018). Como técnica de análise dos dados, foi utilizada a Análise de Conteúdo de Bardin, constituindo-se como uma pesquisa qualitativa. Como resultado aponta-se que há uma razoável frequência da História da Ciência na maioria dos manuais escolares analisados, no entanto, a falta de articulação com os conceitos apresentados transforma-a numa informação isolada, sendo utilizada como complemento do conteúdo.
Anti-spike S1 IgA, anti-spike trimeric IgG, and anti-spike RBD IgG response after BNT162b2 COVID-19 mRNA vaccination in healthcare workers
Authors: Salvagno Gian , Henry Brandon , di Piazza , Pighi Laura , de Nitto , Bragantini Damiano , Gianfilippi Gian , Lippi Giuseppe
Published: June 2021

Background: Most studies on immune response after coronavirus disease 2019 (COVID-19) vaccination focused on serum IgG antibodies and cell-mediated immunity, discounting the role of anti-SARS-CoV-2 neutralizing IgA antibodies in preventing viral infection. This study was aimed to quantify serum IgG and IgA neutralizing antibodies after mRNA COVID-19 vaccination in baseline SARS-CoV-2 seronegative healthcare workers. Methods: The study population consisted of 181 SARSCoV-2 seronegative healthcare workers (median age 42 years, 59.7% women), receiving two doses of Pfizer COVID-19 vaccine BNT162b2 (Comirnaty). Serum samples were collected before receiving the first vaccine dose, 21 days (before the second vaccine dose) and 50 days afterwards. We then measured anti-spike trimeric IgG (Liaison XL, DiaSorin), anti-spike receptor binding domain (RBD) IgG (Access 2, Beckman Coulter) and anti-spike S1 subunit IgA (ELISA, Euroimmun). Results were presented as median and interquartile range (IQR). Results: Vaccine administration elicited all anti-SARS-CoV2 antibodies measured. Thirty days after the second vaccine dose, 100% positivization occurred for anti-spike trimeric IgG and anti-spike RBD IgG, whilst 1.7% subjects remained anti-spike S1 IgA negative. The overall increase of antibodies level ratio over baseline after the second vaccine dose was 576.1 (IQR, 360.7-867.8) for anti-spike trimeric IgG, 1426.0 (IQR, 742.0-2698.6) for anti-spike RBD IgG, and 20.2 (IQR, 12.5-32.1) for anti-spike S1 IgA. Significant inverse association was found between age and overall increase of anti-spike trimeric IgG (r=-0.24; p=0.001) and anti-spike S1 IgA (r=-0.16; p=0.028), but not with anti-spike RBD IgG (r=-0.05; p=0.497). Conclusions: mRNA COVID-19 vaccination elicits sustained serum levels of anti-spike trimeric IgG and anti-spike RBD IgG, while also modestly but significantly increasing those of anti-spike S1 IgA.
A detailed description of the breeding season of a community of birds on the south-east coast of Australia
Authors: Guppy Michael , Overs Anthony , Guppy Sarah
Published: June 2021

The details of a breeding season have been investigated and described for many bird species and groups of species, but rarely for an entire breeding community. The collection of such data is the only way of quantifying the number of birds a habitat can support, how many fledglings it can produce, and the avian diversity that can exist in the habitat. Without these quantitative and qualitative measures, the significance of particular habitats for avian conservation is difficult to assess. We have accumulated comprehensive data on a breeding bird community on a 10 ha site for eight seasons, which has enabled us to condense the many aspects of breeding into an ‘average’ breeding season. The breeding community consisted of 44 species, which used all of the site for nesting. Some species bred each season, while others bred as infrequently as once in the eight seasons. Nesting occurred between the beginning of August and the end of January, different species showed markedly different starting and finishing times, and there were different temporal patterns of breeding within the breeding periods of the different species. The number of pairs that bred on the site varied each season, a pattern that we have previously shown to be related to the value of the Southern Oscillation Index before the start of the season. Nest success rates varied considerably between species, but the overall success rate on the site was approximately 50%. We estimate that the spotted gum forest habitat on the south-east coast of Australia (1200 km2) produces approximately 1.5 million fledglings each season.
Glass Ceiling Factors Hindering Women's Advancement in Management Hierarchy
Authors: Kaftandzieva Tamara , Nakov Leonid
Published: June 2021

Aims: This aim of this paper is to identify the barriers that hinder women’s advancement in the management hierarchy in the financial sector (both banking and insurance) in Republic of North Macedonia, a country historically known for its masculine culture and stereotype–driven expectations regarding the role of woman in the society.

Study design:  Original research paper. Analytical observational, cross-sectional study.

Place and duration of study: The research sample was consisted of male and female employees from banking and insurance sectors in North Macedonia in March 2021.

Methodology: A questionnaire was designed to achieve the objectives of the study in which the items for the barriers have been measured using 5–points Likert scale. The reliability and validity analyses were conducted; descriptive analysis was used to describe the characteristics of the sample as well as the strength and direction of the relationship between the variables, and ANOVA test was employed to examine the proposed three hypotheses.

Results: The obtained results of Cronbach’s alpha are 0.821, 0.836 0.918 for individual, organizational and cultural factors, respectively. The results suggest a significant difference among the barriers (individual, organizational and cultural factors) that prevent employees from obtaining upper–level positions in the organizations due to gender (p <0.001), whereas no significant difference was found among the barriers that prevent employees from obtaining upper–level positions due to age and work experience.

Conclusion: The obtained results call for attention to existence of gender disparities and gender inequalities in many areas of life, particularly in the labor market, when climbing up the corporate ladder. The study contributes to the literature by providing new practical insights into gender diversity initiatives focusing on growth and development aspects of female employees by breaking the glass ceiling and recognizing their competencies, qualifications, and achievement as well as giving them prospects for upward mobility.
Small Steps, Big Gains: Impact of Health Promotion in Combating Viral Hepatitis
Authors: Keshan Pranav , Chaudhary Archita , Rastogi Aayushi , Chauhan Sapna , Syed Sabin , Bansal Akanksha
Published: June 2021

Background: Medical training in health sector is primarily aimed at holistic development of healthcare workers with respect to change in knowledge, attitude and practice, but the majority of trainings merely evaluate the change in knowledge of the participants after attending the training program. Since knowledge gain is immediate whereas change in attitude and practice requires time. Thus, limited evidence is available with respect to the effect of training on attitude and practice over a period of time.

Aim: To assess the effect of training on modification of attitude and medical practices among nursing professionals at least six months of post-training period.

Methods and Material: A longitudinal study from January 18, 2018 to January 31, 2020 was undertaken among nursing professionals who have taken pre and post-test knowledge assessment and have completed six months of post training period. The link to 28-item questionnaire was shared thrice with the eligible participants. All analyses were performed using IBM SPSS Version 22. The statistical significance level considered as p <0.05.

Results: A total of 623 responses were received, of which 534 were included in the final analysis. The median follow-up period for the included participants was 9.4 months (IQR: 8.9–10.3 months). Mean age of the participants was 31.99±7.03years and 68% were females. Approximately 75% agreed that there was a change in their clinical practices with respect to viral hepatitis and approximately 72% unvaccinated individuals got themselves vaccinated post training.

Conclusion: Health promotion through trainings is a pragmatic approach towards combating diseases and achieving sustainable development goals.
Gene expression profiles of breast cancer metastasis according to organ site
Authors: Brasó‐Maristany Fara , Paré Laia , Chic Nuria , Martínez‐Sáez Olga , Pascual Tomás , Mallafré‐Larrosa Meritxell , Schettini Francesco , González‐Farré Blanca , Sanfeliu Esther , Martínez Débora , Galván Patricia , Barnadas Esther , Salinas Belinda , Tolosa Pablo , Ciruelos Eva , Carcelero Esther , Guillén Cecilia , Adamo Barbara , Moreno Reinaldo , Vidal Maria , Muñoz Montserrat , Prat Aleix
Published: June 2021

In advanced breast cancer, biomarker identification and patient selection using a metastatic tumor biopsy is becoming more necessary. However, the biology of metastasis according to the organ site is largely unknown. Here, we evaluated the expression of 771 genes in 184 metastatic samples across 11 organs, including liver, lung, brain, and bone, and made the following observations. First, all PAM50 molecular intrinsic subtypes were represented across organs and within immunohistochemistry‐based groups. Second, HER2‐low disease was identified across all organ sites, including bone, and HER2 expression significantly correlated with ERBB2 expression. Third, the majority of expression variation was explained by intrinsic subtype and not organ of metastasis. Fourth, subtypes and individual subtype‐related genes/signatures were significantly associated with overall survival. Fifth, we identified 74 genes whose expression was organ‐specific and subtype‐independent. Finally, immune profiles were found more expressed in lung compared to brain or liver metastasis. Our results suggest that relevant tumor biology can be captured in metastatic tissues across a variety of organ sites; however, unique biological features according to organ site were also identified and future studies should explore their implications in diagnostic and therapeutic interventions.
Terrorism
Authors: Primoratz Igor
Published: June 2021

The central philosophical question about terrorism is: can terrorism ever be morally justified? Discussion of the moral status of terrorism presupposes that it is reasonably clear what the term means: normative argument calls for convergence on definition.