bluuebunny/crossref_metadata_2025 huggingface dataset:
Modified Robotic Simple Prostatectomy Technique: A Retrospective Analysis of a Series of 162 Surgeries Performed by a High-volume Surgeon
Authors: Bragion¹ Celene Benediti , Cordeiro² Maurício Dener , Faria³ Sandro Mendonça
Published: October 2024

Benign prostatic hyperplasia (BPH) affects up to 80% of men by age 80, with large-gland BPH often treated by simple prostatectomy (SP). This technique significantly improves symptoms but is associated with high rates of complications such as transfusions and infections. Minimally invasive techniques, including robotic-assisted laparoscopic simple suprapubic prostatectomy (RALSP), have emerged as alternatives.
This study reports on 162 patients who underwent RALSP from May 2018 to June 2023. The mean age of the patients was 69 years, mean prostate volume 144.8 cm³, mean robot time 78.7 min, and mean blood loss 183.1mL. Results demonstrated significant improvements in the results: prostate volume (mean decrease from 144.8 to 26.6 cm³), mean PSA level decreased from 7.8 to 0.8 (p < 0.0001), mean IPSS decreased from 23.0 to 4.4 (p < 0.0001), and mean uroflowmetry increased from 6.3 to 22.6 ml/s (p < 0.0001).
No patient experienced worsening erectile function after surgery. All patients showed absence of stress urinary incontinence within 3 months. Catheterization time decreased from 4.2 to 2.6 days over the study period. The postoperative complication rate was 2.29%, with no need for surgical reintervention for complications.
While RALSP showed promising results, further prospective studies are needed to compare it with other techniques. This study highlights RALSP as a viable minimally invasive option for treating large-volume BPH, offering reduced recovery times and fewer complications.
Fractures in children and adolescents with diabetes mellitus during 2001-2020
Authors: Zacay Galia , Gabay Hagit , Tripto-Shkolnik Liana , Gruber Noah , Modan-Moses Dalit , Levy-Shraga Yael
Published: October 2024

Purpose: To compare fracture risk among paediatric patients, between those with diabetes mellitus (DM) and a matched comparison group.
Methods: In this registry-based cohort study, individuals who were diagnosed with DM during 2001-2020, at age 1-17 years, were matched in a 1:5 ratio to a comparison group. Clinical, laboratory and demographic data were obtained from the electronic database of Meuhedet Health Services.
Results: The DM and comparison groups included 1049 and 5245 individuals, respectively. The median age at DM diagnosis was 10.9 years. The median follow-up period of both groups was 5.5 years (IQR 3.6-8.2). We did not find a statistically significant risk for fractures among children with DM (adjusted hazard ratio (HR) 1.10, 95% confidence interval (CI) 0.93-1.31, p=0.25). In a subgroup analysis of boys aged >11 years at DM diagnosis, the adjusted HR for fractures was 1.47 (95%CI 1.06-2.04, p=0.02) relative to the comparison group. In a multivariate analysis, male gender (adjusted HR 1.99, 95%CI 1.46-2.73, p<0.001) and recurrent hospitalizations (adjusted HR 1.53 95%CI 1.02-2.30, p=0.04) were associated with increased risks for fractures among children with DM.
Conclusions: We found increased fracture risk among boys aged >11 years at diagnosis of DM compared to a matched comparison group.
Antral follicle count measured any day of the cycle and menstrual cycle length as reliable markers of ovarian reserve
Authors: Peralta Sara , Fabregues Francesc , Barral Yasmina , Mendez Marta , Goday Anna , Borras Aina , Manau Dolors
Published: October 2024

Background
Routine gynaecological screening should incorporate simple and easily available ovarian reserve markers to ensure optimal reproductive health counselling. The purpose of this study is to evaluate whether antral follicle count measured randomly during the menstrual cycle (rAFC) and menstrual cycle length (MCL) can predict ovarian response in women undergoing assisted reproductive technology.
Methods
122 women with regular menstrual cycles undergoing their first in vitro fertilization cycle were included. Transvaginal ultrasound was performed, and previous and posterior menses’ dates, anti-Müllerian hormone (AMH) and body mass index were recorded. Visits were randomly scheduled: 52 patients were screened in the follicular phase (7 early follicular phase 2–4) and 70 in the luteal phase. Poor ovarian response was defined < four oocytes retrieved or cancellation due to impaired or absent follicular growth and high response as ≥ 15 oocytes. The cumulative live birth rate (CLBR) per initiated IVF cycle was also analysed.
Results
16 patients were classified as high (13.1%), 79 (64.8%) as normal and 27 (22.1%) as poor responders. 51 patients achieved at least one live birth (CLBR = 41.8% per started cycle). rAFC and MCL presented a significant positive correlation with the total number of oocytes retrieved. rAFC showed an excellent ability to predict poor, hyper-response and CLB: AUCROC 0.91 (95%CI 0.84–0.95); 0.83 (95%CI 0.76–0.89) and 0.78 (95%CI 0.70–0.85) while MCL was only a good predictor of poor response AUCROC 0.75 (95%CI 0.66–0.82).
Conclusion
The present study demonstrates that low rAFC and short MCL are strongly associated with poor ovarian response, being reliable markers of poor ovarian reserve.
Study on the landslide caused by difference creep behavior of loess under highway excavation
Authors: Yang Xuanyu , Liu Yaming
Published: October 2024

Large-scale road construction in mountainous areas inevitably leads to numerous excavation slopes, particularly in the Loess Plateau, characterized by abundant ancient landslides and complex stratigraphy. Excavation-induced stress relief can easily reactivate these ancient landslides, posing significant threats to engineering safety. This study takes an ancient landslide in the Loess Plateau as a case example. Field investigations clarified the lithological characteristics of the strata. Indoor triaxial unloading tests were conducted to examine the unloading creep behavior of silty soil and clay located near the sliding zone. Finally, numerical simulations were employed to analyze the evolution process of landslide reactivation induced by excavation. The study revealed the following findings: (1) The primary factor inducing the landslide is the differential unloading creep behavior of silty soil and clay. Silty soil readily reaches an accelerated creep state under unloading conditions, whereas clay remains relatively stable with smaller deformation. The creep behavior of the soil can be well described using the Nishihara model. (2) Comparison of two unloading stress paths showed that vertical stress unloading causes minor rebound deformation with minimal impact on overall deformation. In contrast, lateral stress unloading results in significant soil deformation, which is the main cause of the landslide. (3) During the landslide, there was an abrupt change in pore water pressure within the soil, which can be combined with deep soil deformation as a key indicator for monitoring and early warning of this type of landslide.
Differential symptom relief profiles of menopausal therapies: an online survey study
Authors: Martin-Key Nayra A. , Funnell Erin L. , Tomasik Jakub , Bahn Sabine
Published: October 2024

Background:
While there exist safe hormonal and non-hormonal therapeutic interventions for the menopause, their efficacy profiles are not fully characterized. To use a symptom checklist to examine menopausal symptom relief associated with different treatments.
Methods:
An online survey study was conducted between December 2023 and February 2024. Convenience sampling was conducted, with participants recruited via social media, email, through relevant foundations and support groups, and by word-of-mouth. Inclusion criteria were: (1) ≥ 18 years, (2) assigned female at birth, (3) strong comprehension of the English language, and (4) must be currently experiencing symptoms of the menopause or menopause transition. 3330 respondents consented to participate in the study and of these, 91.95% (N = 3062) who had completed at least 88% of the survey were included in the analysis. Symptom relief per treatment (transdermal hormone replacement therapy (HRT), oral HRT, vaginal HRT, antidepressants, testosterone, cognitive behavioral therapy (CBT)/other therapy/counseling) was assessed using the symptoms included in the Menopause-Specific Quality of Life (MENQOL) questionnaire, which measures four symptom domains: vasomotor, psychosocial, physical, and sexual.
Results:
Data from a total of 3062 respondents were included for analysis (mean age = 51.97, SD = 5.24). Treatment response rates differed significantly across the domains (vasomotor: F(5,2340) = 204.93, p < 0.001, η2 = 0.31; psychosocial: F(5,2340) = 75.12, p < 0.001, η2 = 0.14; physical: F(5,2340) = 65.46, p < 0.001, η2 = 0.12; sexual: F(5,2340) = 89.34, p < 0.001, η2 = 0.16). Transdermal HRT performed better at reducing vasomotor symptoms relative to all other options. Regarding psychosocial symptoms, CBT/other therapy/counseling outperformed all other treatment options. The use of transdermal HRT and testosterone was associated with greater response rates in physical symptoms relative to other treatments. Finally, vaginal HRT and testosterone were associated with significantly higher response rates in sexual symptoms in comparison to all other treatments.
Conclusions:
The findings demonstrate differential response rates to menopausal treatments across symptom domains, underscoring the importance of a comprehensive, multidimensional approach to menopausal symptom management. Utilizing a symptom checklist can facilitate the tailoring of treatment plans for specific symptom profiles and patient needs. The outcomes of this study hold considerable implications for improving and shaping treatment guidelines for the menopause.
Microalgal oil as an alternative source of essential nutrients omega-3 DHA and EPA
Authors: Bailey Eileen , Wojcik Jérôme , Rahn Maike , Roos Franz , Spooren Anneleen , Koshibu Kyoko
Published: October 2024

Omega-3 fatty acids (FA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential macronutrients critical for maintaining healthy cardiovascular, brain, eye, and immune functions. Microalgae offer a promising sustainable source of EPA and DHA due to the possibility to produce an almost unlimited supply of omega-3 FA through a controlled fermentation process. A direct comparison of plasma EPA and DHA bioavailability from microalgal vs. fish oil has not been reported due to the lack of a microalgal oil with appreciable levels of EPA. We analyzed the plasma phospholipid levels of EPA and DHA in 74 healthy men and women after 6 and 14 weeks of consuming omega-3 FA supplements derived from microalgal or fish oil in a randomized, double-blind placebo-controlled parallel group clinical trial. We were able to demonstrate that the plasma phospholipid EPA and DHA levels are statistically the same after supplementation with microalgal and fish oils, indicating that microalgal oil can be a reliable replacement for fish oil to support the high global demand for omega-3 FA.
Susceptibility Assessment and Sensitivity Analysis of Geological Disasters in Chengdu–Chongqing Urban Agglomeration Based on Geographical Detector Model
Authors: Guo Tengjiao , Cao Qi , Ma Yufu , Yang Liejuan
Published: October 2024

The Chengdu–Chongqing urban agglomeration is a significant platform for China’s Western development strategy. However, frequent geological disasters constrain the region’s socioeconomic development and severely affect its natural ecological environment. Evaluating the susceptibility of urban agglomerations to geological disasters and identifying sensitivity factors are crucial for predicting disaster events, assessing disaster risks, and formulating precise disaster prevention and mitigation strategies. The first step in evaluating geological disaster susceptibility is understanding the influence of regional natural geographic conditions on disasters, which is used to identify the main influencing factors and accurately evaluate disaster susceptibility. The key to sensitivity analysis is identifying which interactions between influencing factors have the greatest impact on disasters, thus focusing attention on sensitive areas when formulating mitigation strategies. Therefore, this study constructed a susceptibility assessment model for geological hazards and developed a method for sensitivity identification. Based on geological disaster distribution points, geological and geomorphological conditions, soil and vegetation types, and land use, the four functions of the geographic detector model are used to identify the influencing factors of geological hazards, calculate the forces of influencing factors on geological hazards, divide the susceptibility levels of single factors, detect the interactions between factors, compare the mechanisms of influencing factors on geological hazards, and conduct susceptibility assessment and sensitivity analysis. In order to improve the accuracy of the geographic detector model, various classification methods were tested on discrete data to select the optimal geographic detector results. The results indicate that elevation, soil type, geomorphological type, and vegetation type significantly affect geological disasters; The research area has an elevation greater than 632m, with soil types of primary inceptisols and anthrosols, and landform types of medium-gradient mountain and inland water, lakes, which has a higher susceptibility; The interaction between soil type and soil erosion increases the sensitivity of disasters, and the interaction between soil near rivers and soil subjected to water erosion is highly sensitive.
Beyond Pieces: Role of AI in Chess Strategy Precision
Authors: TIRADO AUGUSTO , PILATTI LUIZ
Published: October 2024

This study analyzes the evolution of strategic precision in chess via quantitative and documentary analysis of 1204 historical matches. Stockfish 16.1 was employed to measure 'Centipawn Loss', and the data were organized via Excel and JASP. The results highlight an increase in precision and a reduction in errors, particularly since the 1990s, emphasizing the role of AI. A significant inverse correlation between precision and centipawn loss (r=-0.85, p<.001) suggests improvement in player skills over time. Champions displayed greater precision than challengers did (t=4.563, df=63, p<.001), with Magnus Carlsen achieving the highest average precision (97.364%) and the lowest variability (CV=2.12%). This illustrates the impact of AI on the development of more sophisticated strategies. The study underscores how AI enhances human intuition and strategic thinking through interactive computational systems. This study concludes that chess players' precision has significantly improved with AI integration, particularly since the 1990s, when unprecedented performance levels in competitive chess have been achieved.
Neutral buoyancy as a simple approach to implement microgravity
Authors: Kim Ho Yong , Kang Sungwook , Oh Se Heang
Published: October 2024

It is well recognized that interesting biological phenomena occur in various organisms, including humans/animals, plants, and bacteria, in the microgravity environment of space. However, there are limitations to investigating these phenomena in real space and under conditions simulating microgravity on Earth. In this study, we developed a simulated microgravity system based on neutral buoyancy. It has been demonstrated that this system facilitates the suspension of cell spheroids for sufficient periods for cell culture and effectively replicates the cellular behaviors observed in actual microgravity environments, such as maintenance of stemness and suppression of osteogenic differentiation, with simultaneous promotion of chondrogenic and adipogenic differentiations in stem cells. Therefore, it serves as a simple and effective platform for various microgravity research endeavors.
The role of the left medial prefrontal cortex and posterior cingulate cortex in processing positive emotion words: Evidence from a meta-analysis and an empirical study
Authors: Dang Qinpu , Ma Fengyang , Chen Jingyu , Guo Taomei
Published: October 2024

In the present research, we examined the neural substrates supporting positive word processing by using Activation Likelihood Estimation (ALE) and Seed-based d Mapping (SDM) approaches. In study 1, taking effect sizes, peak coordinates of brain region activation, sample sizes, and experimental paradigms into consideration in ALE and SDM meta-analyses, we identified two largely overlapping brain regions with comparable peak coordinates, i.e., the left medial prefrontal cortex (mPFC) and the left posterior cingulate cortex (PCC), showing greater activities in these two regions during positive word processing than neutral word processing. In Study 2, we further examined the universality and language specificity of neural mechanisms underlying positive word processing by comparing two typologically distant languages, Chinese and English, in both native speakers and bilinguals using ROI (regions of interest) analyses. The results showed no significant difference across two native languages or between bilinguals’ two languages, highlighting the crucial roles of the two regions in positive word processing. These findings also hold implications for the models of bilingual emotion processing (e.g., the valence hypothesis and the hierarchical emotion model) and the system accommodation hypothesis.
Association of oxidative balance score with biological aging in US adults: a quantile regression analysis
Authors: Jin Yujing , Li Shuyue , Feng Sen , Huang Linyin , Qu Shifang , Cheng Xiaowei , Wang Ruying , Liu Shiwei , Mohamed Zakaria Ahmed , Yao Yan
Published: October 2024

Background
The oxidative stress theory of aging is one of the prominent theories in the field of aging research. The Oxidative Balance Score (OBS) serves as a comprehensive tool for evaluating the effects of different diets and lifestyles on the oxidative/antioxidant system, however, its correlation with biological aging remains ambiguous. We thus conducted this study to explore the relationship between OBS and biological aging in American adults using quantitative measures.
Methods
We conducted a cross-sectional study using the NHANES 1999–2018 database. We examined several biological aging indicators, including biological age, phenotypic age, telomere length, and serum klotho levels. A weighted multiple linear regression model and smoothed fitted curves were employed to analyze the linear and nonlinear relationship between OBS and biological aging markers. Additionally, quantile regression was utilized to further explore their associations.
Results
A significant negative correlation was found between OBS and both biological and phenotypic ages, whereas a significant positive correlation was observed between telomere length and serum klotho levels. Upon comparing the highest tertile of OBS with the lowest tertile, the fully adjusted β values for OBS in the highest tertile were − 0.663 (-0.867, -0.458), -1.792 (-2.190, -1.393), and 32.332 (8.193, 56.471) for biological age, phenotypic age, and serum klotho, respectively. Notably, the positive correlation between telomere length [0.031 (0.007, 0.056)] and OBS was significant only in the partially adjusted model. The negative correlation between OBS and biological aging was consistent in individuals aged over 60 years. In quantile regression, the negative correlation between OBS, DOBS, and LOBS was most significant at the 0.93 percentile of biological age and 0.95 percentile of phenotypic age. Moreover, the serum klotho concentration exhibited a positive correlation with LOBS across all quantiles, with the strongest correlation observed at the 0.95 percentile.
Conclusions
Our study suggests a dose-response relationship between OBS and biological aging, indicating adopting an antioxidant-rich diet and lifestyle may yield beneficial effects on aging. These findings offer theoretical insights into strategies for aging prevention.
A Passive Rectification Mechanism and Its Potential Application in Capturing Energy from Vibrating Graphene Films
Authors: Jiang Jiantang
Published: October 2024

Here we point out that graphene films, which constantly vibrate at the atomic scale, are also a kind of spontaneously formed non-equilibrium ordered structure. A new passive rectification mechanism is proposed here, which utilizes the asymmetric thermal effect of the two junctions of a thermocouple to convert weak alternating current into direct current. Based on the aforementioned rectification mechanism, we also propose a model for capturing the vibration energy from graphene films and conduct quantitative analysis. The analysis shows that the output power of this model is nearly 6.71e-13 watts and it has the potential for further improvement.
Evaluation of Indicators for Participatory and Collaborative Design Process for Public Parks in Malaysia: Analytical Hierarchy Process
Authors:   School of Architecture, Planning and Environmental Policy, University College Dublin, Dublin, IRELAND, Sonet Ungku Norani ,   School of Architecture, Building and Design, Faculty of Innovation and Technology, Taylor’s University, Taylor’s Lakeside Campus, 47500 Subang Jaya, Selangor, MALAYSIA,   Liveable Urban Communities Impact Lab, Taylor’s University, Taylor’s Lakeside Campus, 47500 Subang Jaya, Selangor, MALAYSIA, Klufallah Mustafa ,   School of Built Environment, University of Reading-Malaysia, Educity, 79200 Iskandar Puteri, Johor, MALAYSIA
Published: October 2024

Public participation is deemed relevant and essential for ensuring a holistic approach with equal weighting in implementing the three sustainable pillars of environment, economy and society. Malaysia’s effective implementation of sustainable development frameworks also relies heavily on public participation activities. This participation allows for the incorporation of diverse perspectives, knowledge and experiences, ensuring that decisions and policies address the needs and aspirations of the affected community. This study examines the ranking of indicators for public participation exercises in park design in Malaysia. Using the analytical hierarchy process, 22 indicators from three main clusters were evaluated using a quantitative approach based on the opinions of subject matter experts. The methods of approach, types of public and public park design criteria are discussed in the results for the three construction phases recommended for implementation. This study establishes ranking indicators for each cluster relative to the three stages of development. The findings contribute to improving the present work process of the landscape architecture department at local authorities in Malaysia, ensuring an enhanced, holistic and impactful approach to participatory and collaborative design processes for public parks in Malaysia.
Assessing the Post-Disaster Effects of COVID-19 Pandemic Towards Malaysian Construction Industry
Authors:   Faculty of Engineering, Universiti Malaysia Sarawak, 93400 Kota Samarahan, Sarawak, MALAYSIA, Nee Ting Sim , Xing Ang Chern ,   Faculty of Engineering, Universiti Malaysia Sarawak, 93400 Kota Samarahan, Sarawak, MALAYSIA, Yong Lee Yee ,   Faculty of Engineering, Universiti Malaysia Sarawak, 93400 Kota Samarahan, Sarawak, MALAYSIA
Published: October 2024

Amidst the global upheaval caused by the Coronavirus 2019 (COVID-19) pandemic, substantial disruptions reverberated across nations, including Malaysia, prompting extensive lockdown measures. In response to the virus’s transmission, the Malaysian government enforced the Movement Control Order (MCO) starting on the 18th March 2020. This directive wielded a profound influence, notably impacting diverse sectors within Malaysia, including the construction industry. This study aimed to assess the effects of the COVID-19 pandemic as a post-disaster scenario, with the construction sector as the focal point. The study is executed within the framework of two primary parameters: the occurrence and the significance of the ramifications from the pandemic. A quantitative research methodology was employed, wherein a questionnaire survey was distributed to active industry participants in the construction industry in East and West Malaysia. In total, 197 responses were collected and analysed using the relative importance index technique. Across nine construction domains, 49 effects were investigated. Findings show that the scarcity of materials and workforce, followed by the shortage of labour force especially foreign labour, construction delays stemming from restrictive mandates, revisions in scheduling and work scope and an escalation in material costs are among the top five rankings of the post COVID-19 effects on the construction industry. The outcomes of this research have substantially contributed to the comprehension of the effects induced by the COVID-19 pandemic on the construction industry. The main aim is to amass data that can be leveraged by policy makers to bolster post-disaster management strategies within Malaysia, thereby facilitating the transfer of knowledge for future post disaster management endeavours. Additionally, the study has shed light on the disparities delineated along the regional demarcation of East and West Malaysia.
Producing food supplements by complex processing of fruits and vegetables of reduced quality using biotechnology methods
Authors: Karlov V. A. , Golbraikh A. A. , Mezenova O. Ya.
Published: October 2024

The actuality of processing of substandard by external signs fruit and vegetables is caused by their higher volumes in the processing industry and retail chains, and additionally by their high biopotentials. The aim of research is to ground complex processing of such raw materials to obtain food supplements containing natural biologically active components, and assessment of their nutritional functionality. The experiments used apples, bananas, oranges, potatoes, carrots, tomatoes and cucumbers that did not meet the freshness criteria of GOST 57976-2017, but without any signs of microbial damage. Three types of experimental mixtures were made from this raw material: fruit, vegetable and fruit-vegetable. The key processing operation was the enzymatic hydrolysis of the mixtures with various carbohydrases (cellulase, ?-glucanase, amylase and glucoamylase). The hydrolyzed mixtures were fractionated, followed by dehydration of the fractions to obtain water-soluble and water-insoluble powder supplements. During the fermentation process, the accumulation of simple sugars, dry substances in water-soluble fractions, and the yield of finished products were studied. The highest concentrations of sugars are found in water-soluble fractions from fruit mixtures. In the resulting supplements from three types of mixtures, organoleptic characteristics, chemical composition, and the content of functional food ingredients – vitamin C, substances with P-vitamin activity, and dietary fiber have been studied. The qualitative composition of dietary fiber and other polysaccharides in a water-insoluble supplement has been established using IR-spectra. Taking into account the obtained data, calculations have been made to satisfy the daily physiological needs for established biologically active substances when consuming 100 g of supplements for ordinary people and athletes. It is recommended to use supplements as enriching agents for functional purposes in specialized antioxidant, immunomodulatory and prebiotic nutrition, including as part of dietary supplements for athletes.
Sistema de supervisión aplicado al robot de agricultura de precisión CERES para el cuidado de los cultivos agrícolas
Authors: Moreno Cortes David Santiago , Solaque Guzmán Leonardo Enrique , Velasco Vivas Alexandra
Published: October 2024

La reforma significativa en los procesos de producción que emplean los agricultores para garantizar la cadena alimenticia en Colombia requiere desarrollos que aporten a la optimización de recursos, utilización adecuada de insumos y un menor uso de mano de obra. Para esto, la robótica juega un papel fundamental que puede ayudar a afrontar estos retos por medio de sistemas supervisores capaces de gestionar tareas coordinadas en beneficio del agro. Este artículo presenta el desarrollo de un sistema de supervisión para un robot que brinda cuidado y protección a la salud de los cultivos de papa, orientado a prevenir problemas fitosanitarios, y garantizar la salud de la planta mediante la nutrición necesaria. La estructura del sistema supervisor implementada en el robot agrícola CERES se basa en la teoría de toma de decisiones adaptativa que funciona en tiempo real. El algoritmo de supervisión se integró a la arquitectura de programación general del robot agrícola CERES mediante el lenguaje Python, codificando el algoritmo de supervisión e integrarlo a la arquitectura de programación general con la que cuenta el robot agrícola que para el caso está basada en ROS. Obteniendo una jerarquización de las labores para el cuidado de los cultivos de papa.
Monitoreo remoto de temperatura, humedad y radiación lumínica para un cultivo aeropónico bajo invernadero
Authors: Jaramillo Giraldo Emmanuel , López Rendón Daniel Felipe , Garzón González Jorge Mario
Published: October 2024

En este artículo se presenta el desarrollo e implementación de un sistema de monitoreo remoto para cultivos aeropónicos, donde su enfoque principal es la medición de variables ambientales (temperatura, humedad y radiación lumínica) para su posterior visualización en una plataforma web. La medición de las variables mencionadas se realiza dada la importancia que tienen al momento de cultivar en ambientes cerrados, donde las condiciones del invernadero van a influir en el crecimiento de las plantas. Para la realización del sistema, se plantea el uso del internet de las cosas (IoT) y aplicaciones web. Con el uso creciente del IoT y el poco desarrollo tecnológico en el sector agrario, se busca ayudar a los productores en el cuidado de sus cultivos, implementando un sistema que permite monitorear las condiciones del mismo, para tomar medidas preventivas y generar mayores beneficios y rendimiento en su actividad productiva. Las nuevas tecnologías ayudan a desarrollar proyectos para el sector agrícola, facilitando procesos arduos y de gran consumo de recursos. Desde este enfoque, el aplicativo desarrollado ayuda a obtener mediciones en tiempo real, dando fácil acceso desde dispositivos con conexión a la web, además de permitir al productor a que tome decisiones al respecto.
Caracterización de la cadena de suministro de las plantas aromáticas
Authors: Salamanca-Gómez Tatiana Paola , García Cáceres Rafael Guillermo , Montero Castillo Piedad Margarita
Published: October 2024

Objetivo: Esta investigación tiene como objetivo presentar una caracterización estratégica de las etapas, enlaces, agentes que intervienen en la cadena.Metodología: Hace uso de la metodología desarrollada desde el año 2005 por García y colegas en su más reciente versión (2021), se basa en los siguientes pasos metodológicos: Identificar la misión de la Cadena de Suministro CS, Identificar y describir de manera sintética los agentes involucrados, identificar y describir de manera sintética los productos y subproductos de las plantas aromáticas, Identificar la posición en la CS de los agentes del mercado, Realizar una descripción del sistema logístico de la CS y por último, proporcionar un diagnóstico de la cadena a través de la aplicación del análisis DOFA. Resultados: en las debilidades se halló que existe poco conocimiento sobre la cadena por parte de los stakeholders, como oportunidad existe un potencial en Colombia para el desarrollo de las plantas aromáticas fomentando el impacto nacional e internacional, en las fortalezas Colombia tiene una gran diversidad de portafolio genético y por último, dentro de las amenazas se encuentra el cambio climático.
O setor de saúde: Uma análise das percepções dos agentes de desenvolvimento no município de Ijuí/RS
Authors: Sczmanski Andrei Cossetin , Allebrandt Sérgio Luís , Da Silveira Daniel Claudy , De Oliveira Tarcisio Dorn
Published: October 2024

Essa pesquisa trata da análise do setor de saúde da região do Conselho Regional de Desenvolvimento da Região do Noroeste Colonial (Corede/NORC), do Estado do Rio Grande do Sul, no período entre 2018 e 2020. O objetivo geral buscou analisar o setor de saúde do município de Ijuí e suas possíveis repercussões sobre a dinâmica econômica local/regional. Atenta-se que a hipótese da pesquisa estava intrinsecamente relacionada à importância deste setor, principalmente nos serviços de média e alta complexidade e, por sua vez, suas repercussões sobre o desenvolvimento. Como método de pesquisa, utilizou-se enstrevistas tecnicamente qualificadas, junto aos gestores locais, para verificar as repercussões do setor de saúde na dinâmica regional. Para isso, foram realizados questionários junto a agentes de desenvolvimento tecnicamente qualificados para mensurar a realidade vivenciada. Os resultados aferidos indicaram que Ijuí exerce centralidade na dimensão econômica regional com relação ao setor de saúde, principalmente, quando mesurados os serviços de média e alta complexidade. Pondera-se que o objeto da pesquisa foi influenciado pela repercussão da Pandemia do Covid-19, que teve nesse período efeito mundial. A análise levou em consideração esse fator, com as suas condicionantes que trouxeram distintos modelos de análise de dados. No entanto, a região analisada já registrava tendências que evidenciavam a centralidade regional no setor de saúde, corroboradas com os resultados deste estudo.
Legal relations in criminal proceedings: controversial issues of structure and content
Authors:   Volgograd State University, Dikarev Ilya S. , Davydova Marina L. ,   Volgograd State University
Published: October 2024

Theorists of criminal proceedings traditionally view the legal relationship as a two-way legal relationship of subjects of criminal proceedings regulated by the norms of criminal procedural law, where the right of one subject of the legal relationship corresponds to the legal obligation of another subject. This approach not only prevails in educational literature on criminal procedure, but is also taken as the initial approach when conducting special scientific research. However, in this area there are procedural obligations for which it is impossible to find corresponding rights of any of the participants in the criminal process. The purpose of the study is to clarify the legal nature of such criminal procedural legal relations in which the connection between procedural rights and obligations is not obvious. The authors make an attempt to explain such legal relations from the point of view of the theory of general regulatory relations and to justify their criminal procedural nature. They substantiate the fallacy of the approach that assumes the existence of procedural duties corresponding to each other within the framework of the criminal procedural relationship. The methodological basis of the study was the dialectical method. In addition, general scientific methods of analysis, synthesis and a systematic approach were used, as well as special legal methods: legal interpretation and the formal legal method. The results of the study showed that the public legal obligations of subjects of criminal proceedings constitute an element of general regulatory legal relations in which the state is the authorized party. During the transition of a general legal relationship to the law enforcement level, personalization of the subject composition of the legal relationship may occur when a certain participant in the criminal process (for example, a prosecutor) begins to exercise control over the fulfillment of the procedural duties of the authority. On this basis, the authors conclude that criminal procedural legal relations are not only legal relations that develop between participants in criminal proceedings, but also general regulatory relations that consolidate the competence of government bodies and officials in the field of criminal proceedings.
Futuros em disputa: juventude, educação e projeto de vida no Ensino Médio
Authors: Barbosa Pereira Alexandre
Published: October 2024

A nova Base Nacional Comum Curricular (BNCC) para a educação básica brasileira traz como questão central, principalmente para o Ensino Médio, a importância da escola se aproximar das questões da juventude. Ao anunciar esse objetivo, a BNCC produz um determinado discurso e embasa políticas públicas para a juventude, como a Reforma do Ensino Médio. Na medida em que a noção de juventude é mobilizada, outros termos também despontam como categorias centrais no documento: projeto de vida e empreendedorismo. O artigo analisa e problematiza essas referências na BNCC, indaga sobre quais noções de juventude e futuro são mobilizadas nesse documento e aborda os sentidos de uma ação educativa centrada em uma política pública e pedagogia do projeto de vida cuja finalidade é preparar os estudantes para o empreendedorismo. A pesquisa trabalha fundamentalmente com a análise de discurso da proposta curricular brasileira. A sua principal conclusão é que o discurso sobre a noção de futuro para a juventude construído pela reforma curricular do Ensino Médio não dialoga com a realidade e com as aspirações de futuro dos jovens brasileiros.
Pharmacophore Modelling and Virtual Screening
Authors: Vlasiou Manos C.
Published: October 2024

Pharmacophore modeling and virtual screening are indispensable tools in
modern drug discovery. Pharmacophore models define the essential features and spatial
arrangement required for a molecule to interact with a specific target. Virtual
screening, powered by computational algorithms, efficiently sifts through vast chemical
libraries to identify potential drug candidates. Recent advances in machine learning and
molecular dynamics simulations have further enhanced the accuracy and applicability
of these methods. Pharmacophore modeling and virtual screening continue to play
crucial roles in expediting the drug discovery process, offering a strategic advantage to
pharmaceutical research.
The Use of Density Functional Theory in Computer-Aided Drug Discovery
Authors: Vlasiou Manos C.
Published: October 2024

Density Functional Theory (DFT) has become a cornerstone in Computer-Aided Drug Discovery (CADD), providing accurate insights into molecular
interactions and properties. By predicting binding affinities, electronic structure, and
molecular properties, DFT aids in rational drug design. DFT facilitates the exploration
of crucial pharmacological factors, such as protein-ligand interactions and drug
metabolism. Its computational efficiency enables high-throughput virtual screening,
reducing time and costs in drug development. Continuous advancements in DFT
methodologies and computational resources enhance its applicability in CADD. DFT in
CADD is poised to accelerate the discovery of safer and more effective drugs,
revolutionizing pharmaceutical research.
Software in Computer-Aided Drug Discovery: Empowering Scientific Exploration and Innovation
Authors: Vlasiou Manos C.
Published: October 2024

Software has become an indispensable driving force in Computer-Aided
Drug Discovery (CADD), facilitating target identification, molecular modeling, and
virtual screening. Through bioinformatics and computational biology, software aids in
the efficient identification of drug targets. Molecular modeling software empowers
rational drug design by predicting molecular interactions and structures. Virtual
screening software accelerates hit-to-lead optimization, efficiently sifting through
chemical libraries. Machine learning algorithms and big data analytics enhance
predictive modeling and biomarker discovery, enabling personalized medicine.
Collaborative platforms and cloud-based solutions foster interdisciplinary
collaboration, streamlining the drug discovery process. Software in CADD reduces
costs, shortens development timelines, and fuels innovation, offering unprecedented
possibilities for novel therapeutics and improved healthcare outcomes.
Success Stories in Computer-Aided Drug Discovery
Authors: Vlasiou Manos C.
Published: October 2024

Computer-Aided Drug Discovery (CADD) has yielded remarkable
successes, transforming the pharmaceutical landscape. Notable achievements include
the development of kinase inhibitors for cancer treatment and repurposing of drugs for
emerging health crises like COVID-19. CADD's role in personalized medicine is
exemplified by tailored therapies for genetically defined patient groups in cancer
treatment. Moreover, CADD has enhanced drug development efficiency, minimizing
attrition rates and reducing costs for pharmaceutical companies. These successes
illustrate the pivotal role of CADD in addressing complex diseases, streamlining drug
development, and improving healthcare outcomes. Continuous advancements in
computational techniques and interdisciplinary collaboration promise further
breakthroughs in the field.
The Dual Nature of AI in Information Dissemination: Ethical Considerations
Authors: Germani Federico , Spitale Giovanni , Biller-Andorno Nikola
Published: October 2024

Infodemics pose significant dangers to public health and to the societal fabric, as the spread of misinformation can have far-reaching consequences. While artificial intelligence (AI) systems have the potential to craft compelling and valuable information campaigns with positive repercussions for public health and democracy, concerns have arisen regarding the potential use of AI systems to generate convincing disinformation. The consequences of this dual nature of AI, capable of both illuminating and obscuring the information landscape, are complex and multifaceted. We contend that the rapid integration of AI into society demands a comprehensive understanding of its ethical implications and the development of strategies to harness its potential for the greater good while mitigating harm. Thus, in this paper we explore the ethical dimensions of AI’s role in information dissemination and impact on public health, arguing that potential strategies to deal with AI and disinformation encompass generating regulated and transparent data sets used to train AI models, regulating content outputs, and promoting information literacy.
"Unleash the Power of Metaverse:The New Era of Digital Health Technologies" (Preprint)
Authors: He YenChing
Published: October 2024

UNSTRUCTURED

The Metaverse is a virtual shared space that combines virtual reality (VR), augmented reality (AR) and blockchain technology to create an immersive social and interactive experience. In the medical field, Metaverse can provide simulation training, patient education, remote diagnosis and treatment and other functions to promote the interaction between doctors and patients.

Smart medical care uses advanced data analysis, artificial intelligence (AI), Internet of Things (IoT) and other technologies to improve the efficiency and accuracy of medical services. Smart medical care can achieve personalized diagnosis and treatment, real-time monitoring and predictive analysis, and improve patient health management.

The combination of the two has the potential to change the traditional medical model and make medical services more convenient, accessible and efficient. For example, patients can have virtual medical consultations in the metaverse, and doctors can use smart medical tools for diagnosis and treatment. This not only improves the utilization of medical resources, but also enhances patients' sense of participation and satisfaction. In the future, with the further development of technology, the integration of Metaverse and smart medical care will likely create a new medical experience and service model.
A postmodernist reading of the Epic Sci-Fi poetry, Adventures of Two captains
Authors: Mirzaee Mojdeh , Dehnavi Ellias Aghili
Published: October 2024

Among the works that consider political and social narratives, one can refer to the book "The Adventures of Two Captains," which also represents a kind of postmodern exploration. This work is intertwined with literary techniques, which is one of its prominent features, and serves as a bridge between science fiction stories, utopianism, and critical theories of international relations. However, it should be stated that the mentioned book aims at deconstructing modernist approaches to literature and the power structures that are used while defining global politics. The authors of this work, Elias Aghili and Paul John Amrod, while using epic storytelling intertwined with dystopian and utopian elements, have also used rich literary traditions from both Eastern and Western cultures in this direction. In this regard, this review analyzes the impact of the book on postmodernist discourse, exploring its noted literary techniques and broader thematic issues, especially its critique of power, identity, and narrative in terms of international relations.
The Architecture of the Video Game Stray (2022)
Authors: Amouzad Khalili Hamid , Ma Rui
Published: October 2024

The twenty-first century was marked by emerging ways of space- and place-making. The architecture of the virtual environments of video games is one of the alternative practices in which the discipline of architecture got involved. This essay looks at the architecture and spatial storytelling in the videogame Stray (2022). The relevance of studying Stray does not lie only in the game’s enigmatic interiors, rigorous space-oriented narrative, unique patchwork of neon-soaked, post-apocalyptic labyrinthine spaces, or the cyberpunk Kowloon-like ghettoised urban environment in which the game takes place; Stray is an unprecedented case study as its gameplay is narrated through a non-human perspective: through the point of view of a cat accompanied by a small flying robot called B 12. This essay provides a critical review of the game and attempts to dissect how the spatial storytelling of its post/non-human architecture is orchestrated. Spatial puzzle mechanics, the fluctuation of the game between urban, architectural, and interior scales, and the role that platforms and vertical design techniques play are the subjects of the article. The challenges of the interaction of a game character with four legs with spatial elements, video game placemaking, and spatial design of fetch quests are other topics that the essay will look into. The article is supported by comments from an unpublished interview with Viv (one of the developers of the game) and a series of detailed analytical drawings from the reconstruction of the game environments by the authors.