bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case of Cerebral Toxoplasmosis and Cryptococcosis Preferred Therapy
Associated Adverse Drug Reactions in a Patient Newly Co-diagnosed with
Acquired Immune Deficiency Syndrome
Authors: Suryawanshi Vaibhav Rajendra , Purandare Bharat , Rege Sujata , Panda Bijoy Kumar
Published: July 2022

Purpose:

The simultaneous occurrence of cerebral toxoplasmosis and cryptococcosis is
rare. The infections continue to be treated with sulfadiazine and amphotericin-B-based regimens
(preferred therapy), respectively. Both these drugs are linked to some serious adverse drug reactions
(ADRs). We report such a unique instance of both; the CNS co-infections and adverse drug
reactions to the preferred therapy.

Case Presentation:

A 44-year-old Asian-Indian female was diagnosed with cerebral toxoplasmosis,
impending cryptococcal meningoencephalitis, and acquired immune deficiency syndrome
(AIDS). The preferred therapy of opportunistic CNS co-infections commenced. Within a week, she
had an occurrence of fall in hemoglobin concentrations (11.3 g/dL to 5.6 g/dL; grade IV), reticulocytosis
(1% to 3.2%), and indirect hyperbilirubinemia (0.5 mg/dL to 2.8 mg/dL; grade IV) after
sulfadiazine administration. The drug was discontinued and the patient was treated with hematocrit
transfusions. After amphotericin-B deoxycholate (AmBd) administration, the patient developed
hypokalemia (serum potassium; 4.5 mmol/L to 2.7 mmol/L) and increased serum creatinine (1.0 to
2.2 mg/dL; stage-I) levels. Hence, AmBd was discontinued and potassium correction was given.
The patient got diagnosed with sulfadiazine induced hemolytic anemia and AmBd induced acute
renal failure. He was switched to alternative therapy regimens for the treatment of cerebral toxoplasmosis
and cryptococcosis. Radiological investigations were followed up to confirm the clinical
outcomes of alternative therapy. Complete recovery from the ADRs and opportunistic infections
was observed.

Conclusion:

The preferred therapy regimens for toxoplasmosis and cryptococcosis are accompanied
by potential adverse drug reactions, thus continuous monitoring is vital, especially in
the initial phases of therapy. Discontinuation of the treatment should be the preliminary intervention
in the management. Having said that, alternative therapy regimens had an optimal clinical response
in the present case.
Potential of Mesenchymal Stem Cell Sheets on Periodontal Regeneration:
A Systematic Review of Pre-Clinical Studies
Authors: Mendoza Aldrin Huamán , Balzarini Danilo , Alves Tomaz , Holzhausen Marinella , Rovai Emanuel S.
Published: July 2022

Background::

Cell sheet technique using mesenchymal stem cells is a high-level strategy in
periodontal regenerative medicine. Although recent studies have shown the role of MSCSs in increased
dental supporting tissues and bone, there is no systematic review focused specifically on assessing periodontal
regeneration in orthotopic animal models.

Objective::

To evaluate the potential of mesenchymal stem cell sheets (MSCSs) on periodontal regeneration,
compared to control, in experimental animal models.

Methods:

Pre-clinical studies in periodontal defects of animal models were considered eligible. The electronic
search included the MEDLINE, Web of Science, EMBASE and LILACS databases. The review
was conducted according to the Preferred Reporting Item for Systematic Reviews and Meta-Analyses
statement guidelines.

Results::

A total of 17 of the 3989 studies obtained from the electronic database search were included.
MSCSs included dental follicle (DF) MSCSs, periodontal ligament (PL) MSCSs, dental pulp (DP)
MSCSs, bone marrow (BM) MSCSs, alveolar periosteal (AP) MSCSs and gingival (G) MSCSs. Regarding
cell sheet inducing protocol, most of the studies used ascorbic acid (52.94%). Others used culture
dishes grafted with a temperature-responsive polymer (47.06%). Adverse effects were not identified in
the majority of studies. Meta-analysis was not considered because of methodological heterogeneities.
PDL-MSCSs were superior for periodontal regeneration enhancement compared to the control, but in an
induced inflammatory microenvironment, DF-MSCSs were better. Moreover, DF-MSCSs, DP-MSCSs,
and BM-MSCSs showed improved results compared to the control.

Conclusion:

MSCSs can improve periodontal regeneration in animal periodontal defect models.
Blind-spot monitoring system using Lidar
Authors: Pawar Kuldeep S. , Teli Shivanand N. , Badgujar Kushal D. , Shetye Prasad , Shetty Saukshit , Satam Vedant , Sahani Atul
Published: July 2022

Background:

Most of the mishaps withs vehicles takes place because driver is unable to see objects around a vehicle in the blind spot zone. Any vehicle travelling in the blind spot is under serious threat as its presence is completely unknown to the driver.

Objective:

This research paper proposes a blind-spot
monitoring and alert system that is devised to provide an early
warning with regard to the proximity of surrounding vehicles
to the driver.

Methods:

First, the significance of blind-spot monitoring is
described. Then, the different blind-spot detection
technologies compiled during research are presented. Electronics system along with software in the form of mobile

Conclusion:

Our contributions in this paper are (1) A detailed
study for blind spot detection using Lidar. (2) Design and
development of a retrofittable wireless blind-spot detection
system with high accuracy. Additionally, alarm system that
alerts the driver avoiding mishap has been successfully tested.
Psychomotor development and motor skills in learning in children from 1 to 3 years old
Authors: Cedeño-Roldán Mariuxi Annabel , Reyes-Meza Orley Benedicto
Published: July 2022

The research aimed at the psychomotor development and motor skills in learning in children from 1 to 3 years old and to develop a plan of stimulation activities in the Bejuco Hacha child development center, of the Santa Rita parish. of Canton Chone, who show difficulty in their motor skills, in order to avoid future problems at the time of entering school and respond adequately to the demands set forth by the educators, having as the main cause the care protocol of the center, the systematization of what educators have to do in the areas, axes and areas of development and learning, skills, learning objective, with the purpose of developing an adequate teaching-learning process. The method used was the scientific method, information collection instruments were applied such as surveys, observation sheets and interviews, the results presented reached. It was possible to verify that the children in the age of 1 to 3 years of the CDI of Bejuco Hacha of the broken site the Bejuco, present a good psychomotor development, fulfilling in the activities that were carried out under the guidance of the educators and support of the parents of the family.
International and national standards on societal information security
Authors: Lykhova Sofiia , Servatiuk Liudmyla , Shamsutdinov Oleksandr , Sysoieva Viktoriia , Hurina Dariia
Published: July 2022

This research focuses on information security as a social state, its aspects and characteristics, information security standards, and its impact on improving the information security process. It emphasizes the multidisciplinary nature of the issue of information security. Several methods are employed in this study, including formal-logical and system-structural methods, methods of generalization, and comparative law. Documentary analysis is used to examine the regulatory framework concerning information security and the main international and national information security standards. Three levels of information security are identified –personal, social, and state. It concludes that the levels differ depending on their degree within the information space.
Forensic and technical criminalistics support in cybercrime investigation
Authors: Padalka Andrii
Published: July 2022

The issue of cyber security has become a key State objective in Ukraine. Cyber espionage and cyber-attacks by intelligence agencies (predominantly non-democratic countries) have become the most significant modern threat to automated systems, surpassing ordinary crimes seeking profit. Besides effective protection and immediate responses to counter cyber threats, cyber incident investigations are an important element that must be conducted by authorized law enforcement agencies and intelligence agencies when necessary. This article considers key aspects and issues to suggest practical recommendations to prepare and appoint forensic expertise in cybercrime investigations. Furthermore, it addresses the objects under examination, their removal’s particularities and the questions to ask telecommunications and technical computer experts
Countering the sexual solicitation of children using computer technology
Authors: Semchuk Natalia , Lykhova Sofiia , Udalova Neghdana , Lyseiuk Andrii , Cheban Olesia
Published: July 2022

This article assesses the current state of criminal counteraction to the solicitation of children for sexual purposes using digital technologies in Ukraine and the foreign experience in this area. To this end, it uses the traditional legal research method as a basis for research, partially applying other methods such as comparative, historical, and international law. The article analyzes the composition of a criminal offense under Art. 156-1 of the Criminal Code of Ukraine and compares it to the texts of international acts and foreign legislation. The article concludes that the text of the adopted amendments is generally in line with Ukraine’s commitments and foreign experience.
Физико-механические свойства синтезированных слоев поверхностных сплавов на основе Ti-Ni-Nb, сформированных на поверхности сплава TiNi
Authors: Дьяченко Ф.А. , Семин В.О. , Нейман А.А. , Шугуров А.Р. , Мейснер Л.Л. , Остапенко М.Г.
Published: July 2022

The physical-mechanical properties (microhardness, Young’s modulus, plasticity characteristic, shape recovery ratio) of the synthesized layers of Ti-Ni-Nb-based surface alloys of ~2 μm thickness, formed on the surface of NiTi alloy by the additive thin-film electron beam method were investigated by the instrumented indentation. It was found that the change in physical-mechanical properties in the synthesized surface alloys based on Ti-Ni-Nb is due to their layered structure. In particular, it is due to the thickness of the sublayers, their phase composition, and the structural states of the phases (nanocrystalline and amorphous). It was established that high strength and elastic-plastic parameters of the outer layer and a monotonic change in the physical-mechanical properties from the surface to TiNi substrate are provided in the surface Ti-Ni-Nb alloy with a lower volume fraction of the amorphous phase in the synthesized layers. It was found that the multilayer structure of the surface Ti-Ni-Nb alloy and the monotonically change in the physical-mechanical properties to the substrate ensure high mechanical compatibility of the synthesized layers of surface alloys with the TiNi substrate.
Датчик волнового фронта широкоапертурных лазерных пучков и его применения
Authors: Волкова Л.В. , Казанцев С.Ю. , Музычка А.Ю. , Скобелева В.С.
Published: July 2022

The results of studies of a wavefront sensor based on the Talbot effect, in which a periodic grating made by laser printing is used, are presented. The optical characteristics of periodic gratings printed on polymer films exposed to a continuous radiation density of up to 0.9 W/cm2 have been studied. The possibility of creating efficient configurable wavefront sensors for lasers in the visible and mid-IR spectral ranges is demonstrated.
Оценка характеристик канала радиосвязи в морской среде
Authors: Лукин А.Ф. , Томилин А.К. , Гульков А.Н. , Кремс К.А.
Published: July 2022

The results of data processing obtained in the course of full-scale experiments on the transmission of a short-wave radio signal in the marine environment using special ball antennas are presented. The capacity of the radio communication channel in the modulation frequency band is estimated. Statistical estimates of signals and noises are obtained, which make it possible to calculate decision-making thresholds based on the theory of statistical radio engineering. It is concluded that it is possible to create a two-way voice radio communication channel between mobile underwater objects.
A German Smartphone-Based Self-management Tool for Psoriasis: Community-Driven Development and Evaluation of Quality-of-Life Effects
Authors: Brandl Lea C , Liebram Claudia , Schramm Wendelin , Pobiruchin Monika
Published: July 2022

Background

Psoriasis is a chronic disease characterized by inflammation, increased scaling, itching, and other symptoms. Psoriasis is not contagious, but patients have often felt shunned. Therefore, in addition to psoriasis symptoms, stress, anxiety, and depression can also affect quality of life (QoL). Surveys show that only a quarter of patients are satisfied with the success of their therapy. However, in addition to medical therapy, self-management can also make it easier to deal with chronic diseases like psoriasis.

Objective

The aim of this project was to develop a smartphone-based self-management tool (SMT) specifically for patients with psoriasis using a community-driven process. The impact of the SMT on QoL as well as its acceptance and usability were evaluated.

Methods

In collaboration with an internet-based self-help community, 2 user surveys were conducted to determine the requirements for a smartphone-based SMT. The surveys consisted of semistructured questionnaires asking for desired features in an SMT for psoriasis. A pilot study was conducted to evaluate QoL, acceptance, and usability. Community users were recruited to use the app for 21 days and complete the Dermatology Life Quality Index (DLQI) questionnaire at the beginning (T0) and end (T1). Afterward, participants were asked to complete another questionnaire on usability and ease of use.

Results

SMT requirements were collected from 97 members of an internet-based community. The SMT was built as a progressive web app that communicates with a server back end and an Angular web app for content management. The app was used by 15 participants who also provided qualitative feedback, and 10 participants answered all questionnaires. The average DLQI score was 7.1 (SD 6.2) at T0 and 6.9 (SD 6.6) at T1. The minimal required sample size of 27 was not reached.

Conclusions

The high degree of community participation in the development process and the responses during the requirement engineering process indicated that there is a general need for an independently developed SMT for patients with psoriasis. However, the feedback received after app use shows that the SMT does not meet the needs of the community. It can be concluded that a more customizable app is needed. The focus and needs of the users were very heterogeneous. Similar developments and research could benefit from the findings of this project.
Awareness, Acceptability, and Perceived Effectiveness of Text-Based Therapy Among Graduate Students: Cross-sectional Study
Authors: Blair Samari A , Brockmann Andrea N , Arroyo Kelsey M , Carpenter Chelsea A , Ross Kathryn M
Published: July 2022

Background

Research has suggested that there is a mental health crisis occurring among graduate students in the United States. Moreover, many students go without effective treatment owing to the limited availability of mental and behavioral health resources on college campuses. Text-based therapy may represent a viable method for increasing access to mental health support for graduate students, but little is known regarding its acceptability in this population.

Objective

The purpose of this study was to assess how graduate students perceive text-based therapy and their likelihood of seeking out this form of therapy.

Methods

In total, 265 graduate students completed a cross-sectional web-based survey that included multiple-choice and open-ended questions assessing their perceptions of text-based therapy and the likelihood of seeking out this form of therapy. Chi-square tests, ANOVAs, and nonparametric Wilcoxon signed-rank tests were used to examine differences in multiple-choice questions. The constant comparative method was used for qualitative analyses of the open-ended question responses.

Results

Participants (n=265) were predominately non-Hispanic White (166/265, 62.6%) and female (167/265, 63%) with a mean age of 28.3 (SD 5.1) years. Over half of the participants (139/265, 52.5%) were not aware that text-based therapy existed; however, 65.3% (173/265) reported that they would consider using text-based services, if available. In comparison to face-to-face therapy, participants reported being less likely to seek out text-based therapy and perceived it as less effective (P<.001). Qualitative results indicated that participants were concerned about the ability to effectively communicate and build rapport through text-based therapy and thought that this modality may be more effective for some mental and behavioral health concerns than others. Moreover, participants noted that text-based therapy would be best implemented as a way to supplement, rather than replace, face-to-face services.

Conclusions

Altogether, the results of this study suggest that text-based therapy holds the potential to increase access to and use of mental and behavioral health services; however, graduate students remain concerned about its effectiveness and the optimal methods of implementation. Future research should investigate how therapeutic processes (eg, effective communication and rapport-building) can be facilitated in digital environments and how text-based therapy could be best implemented to supplement and extend, rather than replace, face-to-face services.
Assessing Patient Characteristics Associated with Virtual Visits of Chiropractic Patients in the Veterans Health Administration During the COVID-19 Pandemic: A Multivariable Cross-Sectional Analysis (Preprint)
Authors: Roytman Gregory , Cheung Kei-Hoi , Bathulapalli Harini , Goertz Christine M. , Long Cynthia R. , Lisi Anthony J.
Published: July 2022

BACKGROUND

Non-pharmacological care is recommended as a first line approach to managing musculoskeletal (MSK) pain conditions, yet the COVID-19 pandemic has created obstacles to patients receiving this care and has increased the potential for patients to receive opioids and other pharmacologic forms of pain management. The use of virtual care for non-pharmacological therapies has become an important are of interest. Analyses of patient characteristics associated with such virtual visits has yet to be performed.

OBJECTIVE

To understand the patient characteristics associated with face-to-face (F2F) and virtual visits of patients receiving one type of nonpharmacological management, chiropractic care, in the U.S. Veterans Health Administration (VHA) during COVID-19 pandemic.

METHODS

Demographic data from patients receiving chiropractic care in the VHA were obtained from the VHA Corporate Data Warehouse from March 1, 2020 to February 28, 2021. Patients were grouped into mutually exclusive categories of those having only virtual visits, those having F2F visits, and those having F2F and virtual visits in this study period. Demographics included age, gender, race, ethnicity, marital status, and diagnostic codes (International Classification of Diseases 9th and 10th Editions [ICD-9 and ICD-10]) associated with non-musculoskeletal comorbidities. The diagnostic codes were used to calculate each patient’s Charlson Comorbidity Index. Multinomial logistic regression analysis was performed on demographic and comorbidity data.

RESULTS

The total number of unique patients receiving chiropractic care during the study period was 62,658. Non-White and Hispanic or Latino patients were more likely to attend both Virtual only (Black [odds ratio 1.20, 95% confidence interval (1.10, 1.31)], other races [1.36 (1.16, 1.59)], and Hispanic or Latino patients [1.35 (1.20, 1.52)] and combination F2F and virtual care (Black [1.32 (1.25, 1.40)], other races [1.37 (1.23, 1.52)], and Hispanic or Latino [1.63 (1.51, 1.76)]). We also found associations with patients less than 40 years of age [1.13 (1.02, 1.26)], 66-75 [1.17 (1.01, 1.35)], >75 [1.26 (1.06, 1.51)].

CONCLUSIONS

Patients primarily using virtual chiropractic care or a combination of virtual and F2F care are more ethnically and racially diverse than those using only F2F care. These insights can serve to inform future work assessing virtual non-pharmacological care for MSK conditions.
Determination of qualitative and quantitative characteristics of some lentil cultivars under organic farming conditions
Authors: Önol Burak
Published: July 2022

The increasing population of the world is demanding enhanced agricultural production to fulfill the nutrient requirement of the growing population. However, higher inputs are required to get maximum agricultural production that is resulting higher prices of agricultural products. Therefore, organic farming could be alternative to fulfill the nutrient requirement of the common people with low inputs. Organic farming concepts use environment-friendly practices with low external inputs. The study aimed to check the performance of organically grown four lentil cultivars, namely Eure 20, Sazak 91, Kayı 91, and Sultan 1, to check if their performance was at par with the traditionally grown lentils. The results confirmed that the four genotypes had a high potential for adaptation in the organic farming system.
Incomplete Justice: The Costs of Partial Indemnity
Authors: Abdulla Adil
Published: July 2022

In the mid-twentieth century, Ontario abandoned a simple, full indemnity costs rule in favour of a discretionary, partial indemnity costs regime with hundreds of sub-rules. This article argues that this was a mistake. Partial indemnity has no doctrinal, principled, or practical benefits that cannot be incorporated into a full costs regime. Additionally, partial indemnity carries significant costs to access to justice. Instead, this article proposes a costs regime that incorporates the best features of both the old rule and the new regime. In brief, it proposes a full indemnity rule; capped at the losing party’s costs; with exceptions for divided success, impecuniosity, and public interest cases; and discretionary fines for engaging in misconduct or dilatory tactics. Collectively, these rules would advance access to justice more than the existing costs regime.
Divide-and-conquer verification method for noisy intermediate-scale quantum computation
Authors: Takeuchi Yuki , Takahashi Yasuhiro , Morimae Tomoyuki , Tani Seiichiro
Published: July 2022

Several noisy intermediate-scale quantum computations can be regarded as logarithmic-depth quantum circuits on a sparse quantum computing chip, where two-qubit gates can be directly applied on only some pairs of qubits. In this paper, we propose a method to efficiently verify such noisy intermediate-scale quantum computation. To this end, we first characterize small-scale quantum operations with respect to the diamond norm. Then by using these characterized quantum operations, we estimate the fidelity ⟨ψt|ρ^out|ψt⟩ between an actual n-qubit output state ρ^out obtained from the noisy intermediate-scale quantum computation and the ideal output state (i.e., the target state) |ψt⟩. Although the direct fidelity estimation method requires O(2n) copies of ρ^out on average, our method requires only O(D3212D) copies even in the worst case, where D is the denseness of |ψt⟩. For logarithmic-depth quantum circuits on a sparse chip, D is at most O(log⁡n), and thus O(D3212D) is a polynomial in n. By using the IBM Manila 5-qubit chip, we also perform a proof-of-principle experiment to observe the practical performance of our method.
PENGEMBANGAN BUKU CERITA BERGAMBAR DAN LEMBAR AKTIVITAS SISWA SEBAGAI MEDIA PEMBELAJARAN AGAMA UNTUK SISWA KELAS SATU SD
Authors: Maghfira Yusti Amalia Wahidiyah , Andriani Miranti Widi , Firmansyah Ihwan
Published: July 2022

Learning media must be utilized optimally to help students achieve their learning objectives. Seeing students who are less enthusiastic in their learning process, this research attempts to develop a learning media that can enhance the learning interest of the first grade elementary school students, especially in learning Islamic religion subject. This research is a type of Research and Development or the so-called Research and Development (R&D), with a development model of Analysis, Design, Development or Production, Implementation or Delivery, and Evaluations (ADDIE). The product produced in this study is picture story book and student worksheet for the first grade students of elementary school, entitled I Love the Qur'an. The results of this study indicate that the quality of the product is included in the very feasible criteria with an average score of 4.85 for media experts and 4.132 for material experts. The developed media meets practical criteria with the average score of student response questionnaires for 5 score with a percentage of 100%. The developed media meets the effective criteria with the acquisition of an average score of student post-test results of 85.45 with the accomplishment percentage of 100%.
Crimean Tatar records from Alan Kelly’s catalog
Authors:   Independent Researcher, Izzetov Refat A.
Published: July 2022

The article discusses the issues related to emergence of the first gramophone recordings of the Crimean Tatars at the beginning of the XX century. The list of companies that produced gramophone records with the Crimean Tatar songs and music is given. The article provides an English transliteration of the names of the Crimean Tatar records, which were taken from the catalog of the British scientist, discographer, professor of music at Sheffield University Alan Kelly (1928–2015), indicating recording dates and serial numbers. Finally, the biography of Appaz Sandykchi, one of the performers, is partially restored and presented.
Challenges in the field of toxicity of metals in India including the development of new treatment
Authors:   ICAR-Central Institute of Fisheries Education, Mumbai-400 061, India, Yadav S.R. , Chavan B.R. ,   Department of Aquaculture, College of Fisheries, Ratnagiri-415 629, India, Chadha N.K. ,   ICAR-Central Institute of Fisheries Education, Mumbai-400 061, India, Naik S.D. ,   Department of Aquaculture, College of Fisheries, Ratnagiri-415 629, India, Krishnani K.K. ,   ICAR-Central Institute of Fisheries Education, Mumbai-400 061, India, Sawant P.B. ,   ICAR-Central Institute of Fisheries Education, Mumbai-400 061, India
Published: July 2022

During the last few decades, aquaculture as a useful animal protein providing sector intensifies to meet the growing world population demands. Although fish culture technological advancement has resulted in increased production, intensive technology has negatively affected the environment—consequently, aquaculture research efforts have been diverted towards developing sustainable culture technology. Introducing algae and bacteria singly or in combination in aquaculture was advantageous both by ex-vivo and in-vivo culture techniques. Utilization of microbial consortium in aquaculture can help to construct three pillars (social, economical, and ecological) of sustainability by improving water quality, reducing dependency on a wild fish stock as a feed ingredient, improving the health status of animals, and increasing economic returns along with protection of the environment. Numerous fruitful research outcomes on using algal-bacterial systems are available for its application in aquaculture. In this context, the present article highlights an updated review of current research trends on various aspects such as application of algal-bacterial consortia for aquaculture, available technologies based on their interaction, and recommendations for further improvement. This review will also provide some critical clues for the standardization of novel fish culture techniques based on microbial interaction.
Revealing Berberis aristata potential as an anti-viral agent to combat Paramyxoviridae infection
Authors:   Department of Biotechnology, Prathyusha Engineering College, Chennai-602 025, India, Shreenivasan Y.S. , Keerthana S. ,   Department of Biotechnology, Prathyusha Engineering College, Chennai-602 025, India, Praveena A. ,   Department of Biotechnology, Prathyusha Engineering College, Chennai-602 025, India, Dhasarathan P. ,   Department of Biotechnology, Prathyusha Engineering College, Chennai-602 025, India
Published: July 2022

Aim: To study the anti-viral activity of extracts of Berberis aristata and to scrutinize the novel lead compound present in it probably to combat Paramoxyviridae infection. Methodology: The phytochemicals present in the barks of Berberis aristata were extracted and screened by GC-MS analysis. Haemagglutination inhibition and cytotoxicity assay was performed to determine the anti-viral property, and the novel lead compound was selected using in-silico methods. Results: Haemagglutination assay provided anti-viral activity of the extract at 1/16 dilution in 4 HA viral concentration. At this concentration, the viability on Vero cell lines was precisely 92.8%. The GC-MS analysis enabled in identifying six molecules present in the extract. Among the six compounds present in the extract, five moieties exhibited drug likeliness property when passed through the Lipinski’s drug filter. QSAR predictions using T.E.S.T projected 3 compounds to be developmental non-toxicant with the predicted values of 0.12, 0.32 and 0.42 respectively. On performing docking studies with the predicted nontoxic moieties using iGEMDOCK, with the Sialic acid complexes host receptor, the highest binding energy was -213 kcal mol-1 for alpha-d-mannofuranoside, 1-o-decyl-, respectively. Interpretation: These findings enabled in understanding the anti-viral potency of bark extracts of B. aristata at 62.5mg ml-1 promoting high cellular viability of uninfected cells of host cell with low toxic effects. Probing molecularly, the in-silico analysis helped to predict alpha-d-mannofuranoside, 1-o-decyl as the possible lead molecule supporting its therapeutic efficacy as an anti-viral drug compound in future.
Evaluation of diflunisal a difluoro-derivative of salicylic acid as an inhibitor of human serum albumin using molecular docking tools
Authors:   Department of Physics, PSG College of Arts and Science, Coimbatore-641 014, India, Stephen A.D. , Shankar S.M. ,   Department of Physics, PSG Institute of Technology and Applied Research, Coimbatore-641 062, India, Devi R.N. ,   Department of Physics, Fatima college, Madurai-625 001, India, Maruthamuthu S. ,   Department of Physics, PSG Institute of Technology and Applied Research, Coimbatore-641 062, India, Musthafa A.M. ,   Department of General Studies (Physics Group), Jubail University College (Male Branch), Royal Commission of Jubail, 31961, Kingdom of Saudi Arabia, Pannipara M. ,   Research Center for Advanced Materials Science, King Khalid University, Abha, 62529, Saudi Arabia, Al-Sehemi A.G. ,   Research Center for Advanced Materials Science, King Khalid University, Abha, 62529, Saudi Arabia
Published: July 2022

Aim: To evaluate the binding interaction of diflunisal at active site of Human Serum Albumin (HSA), an important enzyme responsible for osteoarthritis disease. Methodology: The gas phase molecule was optimized with B3LYP/6-311G** basis set, while a single point energy calculation was carried out for the molecule lifted from the active site. Bader’s theory of atoms in molecules (AIM) was used to determine the electron density and Laplacian of electron density. The protein was assigned with polar hydrogens and Kollman charges. Iterated local search procedure was performed during docking, during this, both protein and ligand were considered as rigid. Among the ten poses, lowest binding energy pose was considered for further ligand protein interaction analysis and QTAIM studies. Results: A close observation of the results shows that diflunisal has interactions in the binding sites IIA and IIIA of HSA as reported earlier. Two strong classical H-bonding interactions, three hydrophobic contacts with the amino acids VAL456, ALA194 andARG197, two close fluorine interactions, and two Pi-Sigma interactions have been observed. Apart from the H-bond interactions, the stability of HAS-Diflunisal complex was further empathized by five hyrdrophobic interactions framed between hydroxyl benzoic acid ring with ALA194, GLN459 and ARG197amino acid residue and difluorobenzene ring with ALA194 and VAL456. Interpretation: The results of drug-likeness study showed that diflunisal is highly reactive and less toxic.
Pendalilan Naqli dan ‘Aqli tentang Wujud Allah Menurut al-Ghazali Berdasarkan Kitab Ihya’ ‘Ulum al-Din
Authors: Hamat Mohd Fauzi , Shuhari Mohd Hasrul , Rozali Muhammad Hafizi , Ali Makdom Ahmad Hafiz
Published: July 2022

Issues related to the existence of Allah the Almighty are important topics for debate, in order to differentiate human beings who are muwaḥḥid (believer) and those who are mulḥid (unbeliever). Any denial and misunderstanding of this concept, will certainly lead to denial and misunderstanding of the existence of Allah the Almighty, and it leads to disbelieving. For this reason, Islamic scholars have paid great attention on these issues, by presenting various arguments and specific evidence of their scholarly works to justify the existence of Allah the Almighty. This paper aims to examine the issues related to the existence of Allah the Almighty from the perspective of a famous reformer (mujaddid) of the fifth century, al-Ghazali (d. 505AH), in his book Iḥyā’ ‘Ulūm al-Dīn. This qualitative study was carried out using content analysis of Iḥyā’. This study found out that al-Ghazali has presented in Iḥyā’ arguments such as al-fitrah, nuṣūṣ and intellect in proving the existence of Allah. This finding shows that al-Ghazali has a strong foundation and argument similar to that of Ahl al-Sunnah wa al-Jamā‘ah, who recognize the nature of using proposition via naqlī and ‘aqlī as the source of evidence on proving the existence of Allah the Almighty.
Reflections of Faith (‘Aqidah) on Arts: A Comparative Analytical Study on Islamic and Western Arts
Authors: Salem Qatawneh Mohammad Abdelhamid
Published: July 2022

The study attempts to explore the philosophical, intellectual view of Islamic art that is based on monotheism (tawhīd), and the reflections of ‘aqīdah on it. The study foundationally examines and compares the structures of art within Western mindsets, which stem from pagan embodiments, such as the Greeks and contemporary Darwinism. The study also comes to respond to those who claim that Islamic art stands at the limits of ornamental decorations, or that Islamic art is nothing but a progression of Hellenistic Roman art. The analytical method was employed to examine intellectual texts and their reflections on art in its applied form. A comparative approach is also used in comparing concepts from the Islamic ‘Aqīdah with other theologies and their reflections on art. This study concluded that Islamic art stems from the spirit of tawhīd, consistent with the harmony and oneness of existence. Additionally, Islam was found to be a liberation for art, as it puts artists in the position of choice rather than restricting them in a specific artistic formula as in other ideologies. On the other hand, the study also reveals that the epistemological theory of Western art emerges from a pagan ground or an atheist thought, since it is unable to comprehend the metaphysical world. As a result, nature has entered the list of ‘sanctities’ in the perception of some of the Greek artists and philosophers, which in turn reflected on the purpose of art and its aesthetic role in existence.
Impak Amalan Kerohanian Bagi Mengatasi Kesunyian di Pusat Jagaan Warga Emas
Authors: Mustaffa Nurul Hidayawatie , Mat Akhir Noor Shakirah , Hamjah Salasiah Hanin
Published: July 2022

Issues affecting senior citizens often come under the research radar amongst scholars; one of which is an internal crisis such as loneliness, anxiety, and depression either at home or in old folks’ homes. This research intends to study the spiritual practices like the daily routines of the elderlies residing in Darul Hanan Elderly Care Centre, Penang, as well as analyse their emotional impact, in overcoming loneliness, ensued from their spiritual practices. This is a qualitative study with a case study design. A total of 20 female senior citizens were interviewed. The selection of the study sample used is purposive sampling based on data saturation. The method applied was a semi-structured interview. Research data were analysed descriptively using Atlas.ti. The study finds that there are seven spiritual practices for the elderly at Darul Hanan Elderly Care Centre, Penang. They are daily and compulsory prayers (salat fard) in a congregation, night prayers (qiyamullayl), supplementary (sunat) practices, Qur’anic recitation, chanting praises for Allah (dhikr), chanting for forgiveness from Allah (istighfar), and attending religious lectures. The study also finds that there are 18 positive emotions of the elderly, such as fun, calm, happy, and relieved, after performing spiritual practices that are capable of overcoming loneliness. This makes the spiritual aspect an undeniable measure in overcoming loneliness for the elderly at old folks’ homes in ensuring the happiness of the elderly.
Majalah DABIQ Sebagai Medium Propaganda Pemikiran Tauhid Islamic State of Iraq and Sham (ISIS)
Authors: Wahab Muhammad Rashidi , Hamat Mohd Fauzi , Hanafiah Mohd Hizam , Muhammad Uthman El-Muhammady Ahmad El-Muhammady , Jalil Abdullaah
Published: July 2022

Extremism is an emerging threat confronted by the Muslim world today manifested in the form of a group such as the Islamic State of Iraq and Syria (ISIS) or al-Dawlah al-Islamiyyah fi al-‘Iraq wa al-Sham (DAESH). Undoubtedly, the existence of ISIS and its violence gave negative impacts on Islam and the Muslim ummah worldwide. What is more concerning is that some Muslims in Malaysia were also influenced by ISIS and by so doing it poses threat to our national security. Thus, based on the textual analysis of ISIS document, this article seeks to examine the discourse of tawhid advocated by ISIS, considering the fact that every act committed by Muslims is usually rooted in his or her belief system. To do this, this article focuses on the discourse of tawhid as discussed in DABIQ magazine and it is chosen due to its significance since it is regarded as ISIS mouthpiece to spread its propaganda. Based on the analysis, the article identifies five key elements that constitute ISIS discourse of tawhid, namely (i) the ideological strand of Salafi-Wahabi, (ii) three divisions of tawhid, (iii) tawhid al-Wala’ wa al-Bara’, (iv) tawhid al-Hakimiyyah, and (v) takfirism. The analysis also concludes that ISIS tawhid is not consistent with the mainstream framework of Ahl al-Sunnah wa al-Jama‘ah and thus it should be repudiated.
On the Authorship of Fakhr al-Dīn al-Rāzī’s al-Khalq wa al-Baʿth
Authors: Riswanto Arif Munandar , Wan Abdullah Wan Suhaimi
Published: July 2022

The article seeks to study the work of Fakhr al-Dīn al-Rāzī (543-606 A.H/1149-1209 A.D), entitled al-Khalq wa al-Baʿth. This work is still available in manuscripts and has not hitherto been published yet. This paper discusses the authorship of the above work by al-Rāzī. This encompasses the issue of the ascription of the work to al-Rāzī, the title, the originality and year of the authorship, and information related to the manuscript and its location. This article also describes the nature and the content of al-Khalq wa al-Baʿth as one among al-Rāzī’s works in the field of Kalām.
On the History of the Essay “Visiting Father John of Kronstadt” by Ivan Shcheglov (I. L. Leontiev)
Authors: Fetisenko Olga L.
Published: July 2022

The article reconstructs for the first time the creative history of the memoir essay Visiting Father John of Kronstadt by Ivan L. Leontiev (Ivan Shcheglov) on the basis of the author’s diaries and his correspondence with Sergey A. Rachinsky, Vasily P. Gorlenko, Mikhail O. Menshikov and Priest Iosif Fudel. The essay was published for the first time in 1892, during the revered canonized churchman’s lifetime. The work on this essay coincided with the time of a fundamental spiritual change in the life of a “depressed humorist” (as Ivan Shcheglov was labelled by the critic Alexey A. Izmailov) and was underway in parallel to the completion of a story denouncing Leo Tolstoy’s ideology and the Tolstoyan movement (Around the Truth) and the creation of a story about “psychopathic times” (The Soul on the Wane). Conceived as an ordinary article for the Christmas issue of the Novoe Vremia newspaper, the essay grew both in size and content and was published in the Niva magazine’s book of collected stories and articles, which was followed by a separate edition. An impetus for making the concept more elaborate was the publication of Nikolay Leskov’s story Midnight People, which contained sharp criticism of Father John and his trustees. Abstaining from an open debate with Leskov, Ivan Shcheglov sought to treat the figure of his holy contemporary “with heroic grandeur.”
Creative Laboratory of Afanasy Fet: Translation from A. de Musset
Authors: Kafanova Olga B.
Published: July 2022

The research focuses on the translation of Musset’s elegy “Lucie,” never published during A. A. Fet’s lifetime. The research is devoted to the clarification of the Russian poet’s translation skills and the analysis of the self-worth of his work. Of interest is the question of the time of work on the translation and the reasons for refusing to publish it. Directly influenced by A. de Lamartine, the elegy represents the “new lyricism.” The lyrical hero embodies his grief over the death of his first love, almost a girl, in melancholic musical verses. Another discovery was a new attitude to nature, to which the poet confides his melancholic feelings. The landscape turns out to be his best and closest companion. The structure of the elegy is characterized by repeated complaints; the first and final stanzas coincide. Fet revises the text and reduces some prolixities and divagations to achieve a more natural intimacy. Apparently, he worked on Musset’s elegy in the 1850s, when he found his own poetic language. In general, he managed to improve the text of Musset in some way, to clear the elegy of unnecessary digressions, long notes. As a result of a kind of competition, he creates a poetic masterpiece that is not inferior to the original.
Turgenev’s Characters as Psychological and Cultural Types
Authors: Domanskiy Valeriy A.
Published: July 2022

I. S. Turgenev passes a difficult way in creating his artistic typification of characters, from images of romantic heroes and social types to psychological types in “A Sportsman’s Sketches” and short stories of the 1850s. Already in the essay “Khor and Kalinych” the writer acted as a true innovator. He not only depicted two peasants in their natural environment, but for the first time in Russian literature he created two psychological types of a peasant, found in Russia in a variety of forms and a different combination of characteristic features. In later stories (“The Lull,” “Torrents of Spring”), Turgenev uses new techniques for modeling characters and revealing their psychology: “cinematic” methods of portraying, the use of artistic mirrors, literary reminiscences and allusions. In his novels, characters appear as unique personalities — individuals. The highest level of typification of characters in Turgenev’s works is to consider them as cultural types — Hamlet and Don Quixote and their modifications, which can be traced in his novels “Rudin,” “On the Eve,” “Fathers and Sons.”
Consequências indesejadas das operações de paz de estabilização
Authors: Carvalho Letícia , Rosas Duarte Geraldine
Published: July 2022

O artigo analisa as consequências não pretendidas das operações de paz de estabilização realizadas pela Organização das Nações Unidas (ONU), tomando como base o estudo da atuação da MONUSCO na República Democrática do Congo (RDC). Essas consequências são investigadas tendo em vista cinco aspectos principais: (i) vulnerabilidade da população civil; (ii) segurança do pessoal e das instalações; (iii) ação humanitária; (iv) direitos humanos; e (v) processo político. Metodologicamente, o artigo se baseia em pesquisa bibliográfica e documental, além da análise de dados empíricos sobre a frequência, intensidade e distribuição (espacial e temporal) da violência política, e sobre o processo de reconstrução do Estado no Congo, que permitem avaliar os cinco aspectos elencados. São utilizados dados disponibilizados em bases tanto do próprio sistema ONU quanto de outras fontes, como a ACLED, UCDP, Fund For Peace e Insecurity Insight. Concluímos que as consequências não pretendidas produzidas pela MONUSCO impactam, com pesos variados, a dinâmica do conflito e prejudicam o processo de construção da paz no Congo.
La guadua, una apuesta al cumplimiento de los objetivos del desarrollo sostenible
Authors: Méndez Pedroza Nelly María , Vinasco Guzmán Martha Cecilia , Montealegre Torres William Ignacio , Méndez Pedroza Nelly María , Ramírez Córdoba Gustavo Adolfo , Noriega Ome María de los Ángeles , Valbuena Calderón Oscar Eduardo
Published: July 2022

El libro denominado La guadua, una apuesta al cumplimiento de los objetivos del desarrollo sostenible como documento que permita visualizar los avances de las investigaciones para posicionar la guadua en el sur del Huila, en tres capítulos. El primero, Rutas para la transformación de las sociedades sostenibles; el segundo, Avances en la institucionalidad e instrumentos para la construcción de la cadena productiva de la guadua y el tercero, Propuestas innovadoras de acción por el clima, seguros de que con el debate de estos resultados se enriquece el conocimiento y se avanza en el desarrollo de la cadena productiva de la guadua como la planta del milenio, como el oro verde, como la especie natural renovable de la flora silvestre no maderable que contribuye de cierta manera a minimizar los efectos negativos del cambio climático o variabilidad climática y, en medida mínima pero efectiva, en el cumplimiento de los Objetivos de Desarrollo del Milenio.
Metastatic sigmoid adenocarcinoma to the larynx: a case report and updated literature review
Authors: Aljariri Adham , Nashwan Abdulqadir , Hammoud Rani , Wazwaz Bara , Alhyassat Sameer , Haider Hasan
Published: July 2022

Metastatic laryngeal cancers are rare and usually indicate advanced
disease once they are present; we described a case of a 60 years old
male patient with stage IV colorectal cancer (CRC) who presented to our
clinic with dysphonia; further workups showed metastatic CRC.
MITRAL VALVE REPAIR: REGULATORY OR ETHICAL PROBLEM?
Authors: Fattouch Khalil , Calafiore Antonio
Published: July 2022

The long-term outcome of patients undergoing mitral valve repair (MVr)
is based on what happens during the more or less 60 minutes of aortic
cross clamping necessary to transform a leaking valve in a
well-functioning one. As a consequence, the experience of the surgeon
performing the procedure is the only determinant of the success rate
that deserves to be taken into account. It is clear from the literature
that the number of cases/year is inversely related to the number of
early and late deaths, of repair failures and of reoperations. However,
there is no agreement on the minimum caseload/year that represents the
threshold to identify surgeons that can perform or not MVr. This problem
then cannot be regulated by specific guidelines of by Scientific
Societies, but only by the ethical perception we have of our profession.