bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Molecular Docking and Biological Evaluation of Novel Flavone Derivatives as Potential Anticancer Agents Targeting Akt
Authors: Abo-Salem Heba M. , Gibriel Abdullah A , El Awady Mohamed E. , Mandour Adel H.
Published: March 2020

Background:

Flavonoids are naturally occurring compounds with versatile healthpromoting effects against various diseases.

Objective:

This aim of this paper is to synthesize and evaluate the biological activity of novel flavone derivatives against cancer.

Methods:

A new series of 2-hydroxy-α,β-unsaturated ketones 2a-h, was synthesized via the reaction of N-substituted-indole-3-carboxaldehyde 1a-h with 2-hydroxy acetophenone in the presence of piperidine. The oxidative cyclization of 2a-h using hydrogen peroxide/KOH and/or dimethyl sulfoxide/I2 produced the corresponding 2-(N-substituted-1H-indol-3-yl)-3-hydroxy-4H-chromen- 4-ones 3a-h and 2-(N-substituted-1H-indol-3-yl)-4H-chromen-4-ones 4a-h, respectively. Antiproliferative activities for synthesized series were investigated against HCT-116 colon and MCF- 7 breast cancer cell lines. Molecular downstream effects were evaluated using RT-PCR. Moreover, molecular docking was carried out to pinpoint the binding mode of the most active compounds into the active site of Akt enzyme (PDB ID: 3QKK).

Results:

All compounds exhibited an anti-proliferative activity range of 52-97% and 67.2-99% against HCT-116 and MCF-7, respectively. Compounds 3b, 3h, 3g and 4h had a minimal inhibitory effect on normal BJ1 cells indicating their safety profile. Compounds 3b and 4h, in particular, exhibited the most potent antiproliferative activity against HCT116 and MCF7, meanwhile compounds 3g, 3h and 4g showed potent to moderate activity. Compound 3b had IC50 of 78.3 μM and 53.9 μM against HCT-116 and MCF-7 respectively with comparable IC50 for doxorubicin of 65.1 μM and 45.02 μM. Compound 3b exhibited significant down-regulation for Akt and significant up-regulation of CAS9 and CDKN1genes in all tested cell lines.

Conclusion:

The synthesized flavone derivatives and particularly compound 3b exhibited promising anticancer activity through Akt inhibition.
Interleukin -17 Serum Levels and Polymorphisms in Acute Kidney Injury Patients
Authors: Rahimzadeh Mahsa , Montazerghaem Hossein , Chegeni Sara A. , Naderi Nadereh
Published: March 2020

Background:

Cardiopulmonary bypass (CPB) has been demonstrated to provoke a systemic
inflammatory response believed to be responsible for some of the serious postoperative complications
such as renal dysfunction. Therefore, we tested the hypothesis suggesting that the serum levels of IL-
17A (IL-17), as an inflammatory cytokine, and its gene variants are associated with acute kidney injury
after CPB (AKI-CPB).

Methods :

A total of 135 Iranian patients undergoing cardiopulmonary bypass were included in this
study, of whom 65 (48.1%) developed AKI. Blood specimens were collected preoperatively and at 12
hours postoperatively. The IL-17 gene polymorphisms (rs2275913 and rs3819024) were determined
using sequence-specific primers (PCR-SSP) technique.Pre- and postoperative IL-17 levels were measured
and analyzed in relation to polymorphisms.

Results:

IL-17 concentrations in CBP subjects, were increased after cardiopulmonary bypass
(P<0.00001)but there were no statistically significant differences in IL-17 serum level between AKI
and non-AKI groups. Different genotypes of IL-17 rs2275913 SNP (G→A) were associated with different
circulating IL-17 levels before bypass and also after AKI development. There were no associations
between gene polymorphisms (rs2275913and rs3819024) and incidence of AKI- CPB. There was
an association between thers2275913 SNP and the severity of AKI.

Conclusion:

This study clarified that the rs2275913 SNP to some extent determines plasma IL-17
concentrations in CPB patients. No significant association was found between IL-17 levels or gene
polymorphisms (rs2275913and rs3819024) and incidence of AKI-CPB. Our results suggest that there
is an association between rs2275913 and the severity of AKI- CPB.
PERKEMBANGAN PENGELOLAAN ARSIP ELEKTRONIK DI INDONESIA: TINJAUAN PUSTAKA SISTEMATIS
Authors: Nyfantoro Fajar , Salim Tamara Adriani , Mirmani Anon
Published: March 2020

Introduction. In Indonesia, technology has developed in various fields, this study explores the management of archives in Indonesian institutions still uses conventional archives or manages records electronically. The result of our findings also convey information on the development of electronic records management that has been carried out through a systematic literature review.Methods. A systematic literature review method was used for exploring electronic records management study. The use of this method is designed to search for, assess, and synthesize the best available evidence. The goal is to get informative, evidence-based answers related to the research questions.Analysis. The research will be analyzed based on the theory of Population, Intervention, Comparison, Outcomes and Context (PICOC). Results and Discussion. Carried out through a systematic literature review method, our results found 20 documents that had links with electronic archive management activities. The institution applies electronic archive management by using software technology such as computer-based applications, Android-based applications on mobile phones, and website-based network applications to various processes of archiving activities.Conclusion Our results suggest that the management of institutional records in Indonesia should follow the development by implementing electronic management.
Los precursores (estéticos) de los Breviarios del Fondo de Cultura Económica
Authors: Benedict Nora C.
Published: March 2020

La colección Breviarios es una de las más notables y exitosas del Fondo de Cultura Económica. Transformó completamente la industria editorial latinoamericana debido a la calidad física e intelectual de cada tomo presentado a sus lectores. Para entender mejor el impacto y las raíces estético-educativas de la colección en sí, examinaré una serie de sus precursores globales. En particular, analizaré varias colecciones mundiales de la primera mitad del siglo XX, desde las de Albatross y Penguin Books hasta las de Emecé Editores, por su formato y contenido. Además, compararé y contrastaré las estrategias editoriales y artísticas de esos precursores, para subrayar el carácter novedoso de los Breviarios.
Librerías y bibliotecas. Un problema conceptual
Authors: López Hernández Hugo Daniel
Published: March 2020

El artículo presenta elementos para mostrar la coexistencia de los conceptos librería y biblioteca durante el siglo xviii en Nueva España. Después, analiza la diferencia de tales términos a través de registros de archivo, diccionarios, el libro Bibliotheca mexicana de Juan José de Eguiara y Eguren y pinturas de retratos novohispanos. Se concluye que la diferencia conceptual radica en el uso que daban los poseedores novohispanos a las colecciones de libros.
On An Alleged Paradox of Constency an Material Implication
Authors: Robinson Edward S.
Published: March 2020

Abstract
Skolem's Paradox and Platonism
Authors: Cellucci Carlo
Published: March 2020

Abstract
Nelson Goodman, Languages of Art. An Approach to a Theory of Symbols
Authors: Xirau Ramón
Published: March 2020

Resumen
Logical Questions Concerning the Concept of the Empirical Self
Authors: Walker Jeremy
Published: March 2020

Abstract
Naturalismo ético
Authors: Esquivel Javier
Published: March 2020

Resumen
Metaphilosophy
Authors: Lazerowitz Morris
Published: March 2020

Abstract
B. Russell: Relaciones y universales
Authors: Robles José A.
Published: March 2020

Resumen
Array of Definitions
Authors: Plochmann George Kimball
Published: March 2020

Abstract
La contradicción: ¿vicio formal o cifra de contenido?
Authors: Gutiérrez Claudio
Published: March 2020

Resumen
Lo indecible en el Tractatus
Authors: Villoro Luis
Published: March 2020

Abstract
The Universe of Discourse
Authors: Hudson James L.
Published: March 2020

Abstract
Disposiciones sociales y disposiciones históricas
Authors: D'Alessio Juan Carlos
Published: March 2020

Resumen
The Appropriate Causation of Intentional Basic Actions
Authors: Pears David
Published: March 2020

Abstract
Las creencias y el mundo: sobre las objeciones de Hintikka a Quine
Authors: Simpson Thomas M.
Published: March 2020

Resumen
Susan Haack, Deviant Logic
Authors: Rodríguez Tirado Álvaro
Published: March 2020

Resumen
Comentarios en torno a Bunge, Margáin y la paradoja
Authors: Robles José Antonio
Published: March 2020

Resumen
Validez, inferencia e implicaturas II
Authors: Margáin Hugo
Published: March 2020

Resumen
Ernst A. Moody, Studies in Medieval Philosophy, Science, and Logic
Authors: Otero Mario H.
Published: March 2020

Resumen
Thomas Perry, Moral Reasoning and Truth: An Essay in Philosophy and Jurisprudence
Authors: Esquivel Javier
Published: March 2020

Resumen
The Yellow Book Notes in Relation to The Blue Book
Authors: Ambrose Alice
Published: March 2020

Abstract
Por qué no soy materialista
Authors: Moulines C. Ulises
Published: March 2020

Resumen
Structures versus Sets: The Philosophical Background of Gestalt Psychology
Authors: Grossmann Reinhardt
Published: March 2020

Abstract
La función de la lógica clásica en la llamada "lógica cuántica"
Authors: Lungarzo Carlos
Published: March 2020

Resumen
"Because" and Good Samaritans
Authors: Tomberlin James E. , McGuinness Frank
Published: March 2020

Abstract
John Perry (ed.), Personal Identity
Authors: Villanueva Enrique
Published: March 2020

Resumen
Omnipotencia, Omnisciencia y libertad
Authors: Bulygin Eugenio
Published: March 2020

Resumen
Explicaciones teleológicas en biología. Panorama actual y antecedentes históricos
Authors: Ponce T. Margarita
Published: March 2020

Resumen
Respuesta a Rodríguez Larreta y Orayen
Authors: Bulygin Eugenio
Published: March 2020

Resumen
The Neglected Freedom
Authors: Gould James A.
Published: March 2020

Abstract
Wladislaw Krakewski, Correspondence Principle and Growth of Science
Authors: Otero Mario H.
Published: March 2020

Resumen
Consideraciones sobre "derecho y lógica" de Hans Kelsen
Authors: Schmill Ordónez Ulises
Published: March 2020

Resumen
Eduardo A. Rabossi, La justificación moral del castigo
Authors: Vernengo Roberto J.
Published: March 2020

Resumen
Fundamentos del derecho y fundamentos del conocimiento del derecho
Authors: Caracciolo Ricardo Alberto
Published: March 2020

Resumen
Nota sobre la similitud y los colores
Authors: García Díaz Adolfo
Published: March 2020

Resumen
La conciencia: intentos de definición
Authors: Kolteniuk Miguel
Published: March 2020

Resumen
Leonard Linsky, Names and Descriptions
Authors: Tomasini Alejandro
Published: March 2020

Resumen
A.I. Arruda, R. Chuaqui y N.C.A. da Costa (eds.), Non-Classical Logics, Model Theory and Computability
Authors: Lungarzo Carlos
Published: March 2020

Resumen
Sobre los fundamentos de la termodinámica y el materialismo
Authors: Gómez César , Quintanilla Miguel A.
Published: March 2020

Resumen
Stephen R.L. Clark, Aristotle’s Man. Speculations upon Aristotelian Anthropology
Authors: Osmanczik Ute Schmidt
Published: March 2020

Resumen
Anthony Kenny, Aquinas
Authors: Villanueva Enrique
Published: March 2020

Resumen
Martin Gardner, Aha! (Aha! Insight)
Authors: Robles José Antonio
Published: March 2020

Resumen
Las ciencias naturales y los valores
Authors: Cordero Alberto
Published: March 2020

Cordero reconsiders —from the post-Kuhnian view of Natural Science— the fact/value dicotomy. His analysis involves: (1) inquiring about the limits of objectivity, and (2) challenging the empiricist tradition in the areas of value theory and objectivity. The author examines Putnam’s position, according the which, a fact always depend upon a value and every value materializes itself in a fact.

Putnam also claims that predicative control is fundamental for Natural Sciences and makes objectivity possible. Cordero thinks that besides predicative-objectivity, so appreciated in Natural Sciences, there are other forms of objectivity. They might be forms grounded on other virtues than those mentioned by Putnam, e.g. the virtue of searching for human liberation.[J. F.]
Killing, Letting Die, and Thomson
Authors: Belliotti Raymond A.
Published: March 2020

Judith Jarvis Thomson ha expresado desconcierto ante el significado de “Matar es peor que dejar morir”. Un examen de cinco posibles interpretaciones de tal expresión sugiere que su sentido más plausible es el de que “cualquier violación del deber negativo de abstenerse de matar es un acto moralmente peor, ceteris paribus, que cualquier violación del correlativo deber positivo de salvar vidas”. La cláusula “ceteris paribus” requiere que las intenciones, las motivaciones, las consecuencias actuales y previsibles de un acto, así como los esfuerzos que se requieren para cumplir los deberes, sean los mismos para los violadores de los deberes respectivos. Se concluye que quienes sostienen que matar es peor que dejar morir están sugiriendo que esto es así porque existe un factor lógica o empíricamente necesario que, ceteris paribus, proporciona una razón dispositiva para pensar que quien mata realiza un acto moralmente peor que quien deja morir a otro. Esto es, sugieren que la distinción entre matar y dejar morir es moralmente relevante y que, ceteris paribus, proporciona una razón concluyente para pensar que las violaciones a un deber negativo son actos moralmente peores.

El desconcierto de Thomson en cuanto al significado de “Matar es peor que dejar morir” proviene de su incapacidad para distinguir entre dos preguntas diferentes: ¿Son los actos que lógicamente implican la muerte peores que los actos que no lo hacen? ¿Es peor decapitar a alguien que golpearlo en la nariz? Una vez que distinguimos entre estas dos preguntas, podemos aclarar las cuestiones que se debaten y resolver el desconcierto.

[R.A.B.]
Predication: New and Old
Authors: Angelelli Ignacio
Published: March 2020

Resumen
Roderick M. Chisholm, Person and Object. A Metaphysical Study
Authors: Villanueva Enrique
Published: March 2020

Resumen
C. Ulises Moulines, El desarrollo moderno de la filosofía de la ciencia (1890–2000)
Authors: Ávila del Palacio Alfonso
Published: March 2020

Georg Theiner, Res cogitans extensa. A Philosophical Defense of the Extended Mind Thesis, Peter Lang, Fráncfort del Meno, 2011, xiv + 267 pp.
Denis Dutton, El instinto del arte. Belleza, placer y evolución humana
Authors: Ortiz-Millán Gustavo
Published: March 2020

Denis Dutton, El instinto del arte. Belleza, placer y evolución humana, trad. Carme Font Paz, Paidós, Barcelona, 2010
Medios y consecuencias necesarias. Observaciones acerca de la responsabilidad penal y la doctrina del doble efecto
Authors: Manrique María Laura
Published: March 2020

Este trabajo insiste en la utilidad de la distinción entre medios y consecuencias en la atribución de responsabilidad penal. La estrategia argumental se basa en algunas de las principales intuiciones de la doctrina del doble efecto. En particular, se analiza el modo en que esta doctrina moral traza la diferencia entre daño instrumental y daño incidental. Dado que en la filosofía moral contemporánea se ha criticado severamente esa distinción, se elabora una respuesta a esas críticas. Finalmente, se subraya no sólo en qué sentido es diferente intentar y prever un daño sino también por qué los daños instrumentales cuentan también como daños intentados por el agente.
“Una imagen de la realidad geométrica”: la concepción axiomática de la geometría de Hilbert a la luz de la Bildtheorie de Heinrich Hertz
Authors: Giovannini Eduardo N.
Published: March 2020

El artículo presenta una interpretación del abordaje axiomático temprano a la geometría de David Hilbert, i.e., el desarrollado entre 1891 y 1905. Se sostiene que diversos aspectos de este abordaje, a primera vista problemáticos, se pueden comprender mejor si se contrastan con una de sus influencias más importantes en este periodo: la teoría pictórica [Bildtheorie] de Heinrich Hertz. En particular se argumenta que un análisis de la concepción axiomática de Hilbert a la luz de la teoría de Hertz permite aliviar ciertas tensiones en la concepción hilbertiana; más precisamente, las tensiones que surgen de mantener, al mismo tiempo, una posición axiomática abstracta o formal y una concepción empirista de la geometría, que la considera una ciencia natural.
Deliberación y confianza en el mundo. Sobre Morality, Self-Knowledge and Human Suffering, de Josep Corbí
Authors: Broncano Fernando
Published: March 2020

Josep E. Corbí, Morality, Self-Knowledge and Human Suffering. An Essay on The Loss of Confidence in the World, Routledge, Londres (Routledge Studies in Contemporary Philosophy, 38), 2012, 254 pp.
Mauricio Suárez (comp.), Fictions in Science: Philosophical Essays on Modeling and Idealization
Authors: Méndez Granados Diego
Published: March 2020

Mauricio Suárez (comp.), Fictions in Science: Philosophical Essays on Modeling and Idealization, Routledge, Londres/Nueva York (Routledge Studies in the Philosophy of Science, 4), 2009, 282 pp.
The Language of Publication of “Analytic” Philosophy
Authors: Rodriguez-Pereyra Gonzalo
Published: March 2020

This note argues that research in analytical philosophy broadly conceived should be published exclusively in English. Reasons are given for this and the thesis is defended against thirteen objections.
Mark Colyvan, An Introduction to the Philosophy of Mathematics
Authors: Soto Cristian
Published: March 2020

Mark Colyvan, An Introduction to the Philosophy of Mathematic, Cambridge University Press, Cambridge, 2012, 188 pp.
Encuentros cercanos con argumentos del “tercer tipo”: razonamiento plausible y probabilidad subjetiva como modelos de evaluación de argumentos
Authors: Gaviria Christian , Jiménez-Leal William
Published: March 2020

Este artículo presenta un análisis comparativo de los modelos de argumentación basados en las nociones de probabilidad subjetiva y de razonamiento plausible. Se hacen explícitos los “parecidos de familia” entre probabilidad y plausibilidad, y se examinan las diferencias en las prescripciones invocadas para la evaluación de tres tipos de falacias informales: apelación a la autoridad (ad verecundiam), a la popularidad (ad populum) y petición de principio (petitio principii). Se concluye que el razonamiento plausible, como Rescher y Walton lo describen, no proporciona una alternativa sólida a la probabilidad como modelo normativo o descriptivo de la evaluación de argumentos.
La noción positiva de ciencia de Paul Karl Feyerabend
Authors: Gargiulo de Vázquez María Teresa
Published: March 2020

El pensamiento de Feyerabend ha sido objeto de múltiples y divergentes interpretaciones, entre las que parece ser unánime la inscripción de su obra dentro de las coordenadas de un escepticismo radical. Estas lecturas encuentran parcialmente sustento en su anarquismo epistemológico, el cual constituye en sí mismo una reducción al absurdo de los intentos del positivismo lógico y del racionalismo crítico de definir axiomática o metodológicamente la ciencia. En este sentido, su obra puede ser entendida, en parte, como una argumentación negativa y escéptica con respecto a aquellas nociones de ciencia. No obstante, esta hermenéutica no deja de ofrecer una visión fragmentaria y parcial de su pensamiento. El propósito de este artículo es reconstruir el itinerario intelectual a partir del cual Feyerabend va madurando su comprensión positiva de la ciencia para trascender las hermenéuticas de su obra en la clave del escepticismo.
Beth Preston, A Philosophy of Material Culture. Action, Function, and Mind
Authors: Parente Diego , Crelier Andrés
Published: March 2020

Beth Preston, A Philosophy of Material Culture. Action, Function, and Mind, (Routledge Studies in contemporary philosophy, v. 48), New York, Routledge, 2013, 264pp.
La abstinencia epistémica
Authors: Curcó Cobos Felipe
Published: March 2020

Me propongo analizar críticamente la idea de abstinencia epistémica desarrollada por un importante grupo de teóricos liberales a partir de los años ochenta del siglo pasado. Para los propósitos del liberalismo político la propuesta de la abstinencia epistémica desempeña un papel crucial. Consiste en garantizar el consenso en torno a las reglas procesales y principios públicos de justicia, exigiendo que la pluralidad de intereses y concepciones sustantivas que coexisten en la sociedad se abstengan de realizar atribuciones de verdad sobre sus propias concepciones morales cuando éstas son debatidas en la esfera pública. Mi argumento es que esta estrategia fracasa toda vez que la abstinencia epistémica no resiste la aplicación de sus propias cláusulas a sí misma.
Prácticas, contextos y racionalidad epistémica:
Authors: Caamaño Alegre María De la Concepción
Published: March 2020

Sergio Martínez, Xiang Huang y Godfrey Guillaumin (comps.), Historia, prácticas y estilos en la filosofía de la ciencia. Hacia una epistemología plural, Universidad Autónoma Metropolitana–Unidad Iztapalapa/División de Ciencias Sociales y Humanidades/Porrúa, México, 2011, 356 pp. MARÍA
Términos numéricos
Authors: Curcó Carmen
Published: March 2020

El significado de los términos numéricos es objeto de debate en la lingüística, la pragmática y la filosofía del lenguaje. En este trabajo defiendo una versión contextualista en la cual propongo que, más que consistir en un concepto específico, la semántica de los términos numéricos es una vía convencional para activar cognitivamente una zona conceptual que contiene a los conceptos numéricos que pueden expresarse a través de su uso. Las interpretaciones que un término numérico puede recibir están dadas por la interacción de la forma lógica del enunciado en que aparece, la activación de una zona conceptual específica y la búsqueda de relevancia óptima. Esta propuesta explica evidencia lingüística y empírica de la que otras posturas no pueden dar cuenta.
Conceptual Reconstruction and Epistemic Import: Allosteric Mechanistic Explanations As a Unified Theory-Net
Authors: Alleva Karina , Díez José , Federico Lucía
Published: March 2020

The goal of this article is to show that formal analysis and reconstructions may be useful to discuss and shed light on substantive meta-theoretical issues. We proceed here by exemplification, analysing and reconstructing as a case study a paradigmatic biochemical theory, the Monod-Wyman-Changeux (MWC) theory of allosterism, and applying the reconstruction to the discussion of some issues raised by prominent representatives of the new mechanist philosophy. We conclude that our study shows that at least in this case mechanicism and (some version of) more traditional accounts are not rivals but complementary approaches.
Bulygin-redondo: desencuentros cercanos sobre enunciados Hartianos del tercer tipo
Authors: Scataglini María Gabriela
Published: March 2020

En este texto comparo las concepciones de Eugenio Bulygin y Cristina Redondo acerca de aquellos enunciados que dan cuenta de que en una sociedad se aceptan ciertas reglas como pautas de conducta. Me concentro en la pregunta acercade qué es lo que posibilita al observador “identificar”, “reconocer” normas jurídicas válidas en cuanto tales. Inspirada en el enfoque wittgensteiniano acerca del seguimiento de reglas —retomado a su vez por la crítica de Brandom al “regularismo”—, planteo una respuesta que discrepa de la de Bulygin y coincide con la de Redondo en un punto en el que ambos difieren; mas señalo una sutil —aunque crucial— diferencia con esta última.
Editorial
Authors: Pacheco-Salazar Berenice
Published: March 2020

No precisa de un resumen.
Faktor-Faktor yang Mempengaruhi Pengadaan Melon (Cucumis Melo L) di Pasar Induk Osowilangun Surabaya
Authors: Maykamas Prafi Fachjurin , Ningsih Gumoyo Mumpuni , Bakhtiar Ary
Published: March 2020

Kegiatan untuk mendatangkan persediaan merupakan pengadaan, pengadaan barang merupakan suatu kegiatan untuk mengatur bagaiman barang masuk sesuai dengan kebutuhan pasar. Kegiatan tersebut sangat berguna dan perlu diperhitungkan untuk menjaga barang tersebut dari kerusakan atau pembusukan (buah atau sayur) dari terlalu lamanya barang diadakan untuk persediaan pasar. Tujuan dari penelitian ini merupakan untuk mengetahui faktor-faktor (harga beli melon, harga jual melon, biaya transportasi dan biaya pemeliharaan) yang mempengaruhi pengadaan melon dipasar dan kendala atau resiko pengadaan. Metode pengambilan data menggunakan accidental sampling atau pengambilan sampel secara kebetulan dan jenis data yang digunakan adalah data primer dan juga sekunder. Metode pengumpulan data yaitu dengan observasi, kuisioner, dan wawancara dan metode analisis yang digunakan yaitu uji t. Hasil dari penelitian ini yaitu bahwa variabel biaya transportasi dan biaya pemeliharaan melon merupakan variabel yang berpengaruh signifikan terhadap pengadaan melon. Resiko atau kendala dalam melakukan pengadaan antara lain tentang supliyer yang dimiliki pedagang di area jawa timur, biaya transportasi yang lebih ringan, kualitas melon yang dapat dipantau, harga yang tidak berbeda jauh dengan diluat jawa timur,resiko pengiriman, persaingan hargaKata kunci: Biaya Transportasi, Harga Melon, Biaya Pemeliharaan
A. Zhaksylykov’s novel “Singing Stones” in aspect of the literary domain theory
Authors: Valikova Olga A. , Bakhtikireeva Uldanai M.
Published: March 2020

The authors of the article believe that the symbolic systems to which the language belongs form structured databases in a certain way - domains that develop according to specifi c rules and aff ect the culture of a language community. According to the hypothesis of the research presented in the paper, Russian-language literature is a special cultural domain generated by the ethnogenetic (in this case, Kazakh) and canonical (Russian) fi elds of culture. It was found that at the crossroads of cultures - and literatures - a new aesthetic phenomenon is being formed, which modern literary criticism has yet to describe. The main objectives of the study included interpretation of the text by the method of hermeneutic commentary, elimination of linguocultural lacunae, and complex poetic analysis. The research material was the fi rst pentalogy novel by A. Zhaksylykov “Dreams of the Damned” - “Singing Stones”. The authors conclude that modern Russian literature gravitates not so much to the Russian (in the strict sense of the term) language fi eld as to the Russophonic or translingual fi eld, using the term by professor Steven Kellman.
The mythologem “Home” in the art discourse of Tatar and Chuvash literatures
Authors: Abasheva Diana V. , Sharyafetdinov Ramil Kh.
Published: March 2020

Comparative study of the cultures of the Volga region folks leads researchers to conclusions characterizing the centuries-old interaction of peoples, which resulted in the formation of unique artistic systems of the Tatar and Chuvash nations. The article considers the functioning of the mythologeme “Home” in the Chuvash and Tatar literatures and determines its fundamental importance both in classical and modern works (end of 20 - begining of 21 century). The authors analyze the poetic meanings (motif of memory, happiness, faith, life, etc.) and identify the most frequent values (native speech, a symbol of security, wealth, beauty and peace), that combine in their understanding the idea of Home in the Chuvash and Tatar cultures. The mythologem “Home” in Tatar and Chuvash literatures is related to the problems of works and refl ects the mentality of the people.
Axiological archetype “Home” in I. Shukhov autobiographic trilogy “Presnov Pages”
Authors: Sinyachkin Vladimir P. , Demchenko Alyona S.
Published: March 2020

The article is de voted to the reconstruction of the archety pe “Home” based on the material of the biographical trilogy by I. Shukhov “Presnov Pages”. The authors conclude that archetypes can be identical to axiological units, as they transmit information about the value attitudes of a community. The “Presnov Pages” trilogy is distinguished by a mnemonic narrative, which is characterized by a special accentuation of meanings. The authors use comparative analysis and hermeneutic commentary, concluding that the archetype “Home” is key to Shukhov’s work.
The image of a dragon in the poetry of N. Gumilev: Chinese subtext
Authors: Porol Polina V.
Published: March 2020

The article discusses the image of a dragon in the poetry of N. Gumilev. New in the work is the hypothesis on the intertextuality of the poems by N. Gumilyov “The Poem of the Begining” and A. Tolstoyʼs “Dragon”. The Chinese subtext of the image of the dragon in the poetry of N. Gumilev is grounded. The relevance of the topic is due to the development of the study of the mutual perception of Russian and Chinese cultures in the space of a poetic text. At the same time, the problem of reception of the image of China in the poetry of the Silver Age remains not yet fully understood. The objectives of the study were to identify, describe and interpret the Chinese subtext of the image of the dragon in the poetry of N. Gumilev; consideration of the authorʼs reception; comparing the perception of the image of the dragon in the culture of Russia and China. The results of the study showed: the frequency of the image of the dragon in the poetry of N. Gumilyov, the poet’s use of this image as originally Chinese; the relationship of the description of the image of the dragon in the works of N. Gumilyov and A. Tolstoy; the poet’s appeal to Chinese mythology and hieroglyphic writing. The author’s reasoning and conclusions are based on critical research, a comparison of two cultures. An analysis of the poetic works of N. Gumilev was carried out in a semantic aspect using the method of text parallels. The study of the image of the dragon in the poetry of N. Gumilev allows to approach the worldview of the culture of the Silver Age on one more side.
On the first English translation of Sasha Sokolov’s novel “Between Dog and Wolf”
Authors: Zakharyan Armen A.
Published: March 2020

The article is devoted to the analysis of the main problems and challenges (as well as their solutions) of the fi rst English translation of the novel “Between Dog and Wolf” written by Sasha Sokolov in 1980. For a few decades this novel had no English translation, until the work of Alexander Boguslawski, Sokolov’s friend and translator. In this article we analyze and summarize the diffi culties of this text for translation and the ways Boguslawski solved them, based on his own experience that he shared in the fi rst English edition of the novel: “Between Dog and Wolf”. Columbia University Press, 2016. 296 p. (Russian Library).
The Temporal and Chroonological Distance in Translations of Holy Writ: to Preserve or to Eliminate?
Authors: Khukhuni Georgy T. , Valuitseva Irina I. , Osipova Anna A.
Published: March 2020

The present paper deals with some cases of the modernization of the Bible texts, especially created in the second part of the 20th and the beginning of the 21st centuries (although the elements of the latter may be found in earlier versions including those with the unofficial status of “national Bibles”). The expansion of modernization is usually connected with E. Nida`s theory of the dynamic / functional equivalence; at the same moment its direct influence is obvious enough. The actuality of the theme for the theory and practice of translation is caused by the following factors: 1. the richness and variety of the Bible translations, the history of which counts more than two thousand ears; 2. the necessity to take into account the referential part of the text on one hand, and its pragmatic and appellative functions on the other; that may lead to the collision between them when the translator has to choose the strategy and tactics of his work; 1. the acceptance of the text as “inspired by God” among the believers, that may provoke a negative relation towards some moments, which are treated as the divergence from the source text or even its distortion. The paper is based on the representative sample taken from Bible translations (both “traditional” and modern) in Russian, English and German. The corresponding variants, as well as their estimation in special and popular works are analyzed. The authors give an attempt to define some features that give the possibility to treat the text as modernized one. Although the said method is used quite often as the means to reach the adequacy of translation, the question of its limits is controversial enough.
Application of Contemporary Proof of the Sforza Formula to Computation of Volumes of Hyperbolic Tetrahedra of Special Kind
Authors: Krasnov V. A.
Published: March 2020

In this paper, we use the contemporary proof (by Abrosimov and Mednykh) of the Sforza formula for volume of an arbitrary non-Euclidean tetrahedron to derive new formulas that express volumes of hyperbolic tetrahedra of special kind (orthoschemes and tetrahedra with the symmetry group S 4) via dihedral angles.
Strongly Elliptic Differential-Difference Equations with Mixed Boundary Conditions in a Cylindric Domain
Authors: Liiko V. V. , Skubachevskii A. L.
Published: March 2020

We consider strongly elliptic differential-difference equations with mixed boundary conditions in a cylindrical domain. We establish the connection between such problems and nonlocal mixed problems for strongly elliptic differential equations, and prove the uniqueness of solutions.
MG53 Does Not Manifest the Development of Diabetes in db/db Mice
Authors: Wang Qiang , Bian Zehua , Jiang Qiwei , Wang Xiaoliang , Zhou Xinyu , Park Ki Ho , Hsueh Willa , Whitson Bryan A. , Haggard Erin , Li Haichang , Chen Ken , Cai Chuanxi , Tan Tao , Zhu Hua , Ma Jianjie
Published: March 2020

MG53 is a member of the TRIM protein family that is predominantly expressed in striated muscles and participates in cell membrane repair. Controversy exists regarding MG53’s role in insulin signaling and manifestation of diabetes. We generated db/db mice with either whole-body ablation or sustained elevation of MG53 in the bloodstream in order to evaluate the physiological function of MG53 in diabetes. To quantify the amount of MG53 protein in circulation, we developed a monoclonal antibody against MG53 with high specificity. Western blot using this antibody revealed lower or no change of serum MG53 levels in db/db mice or patients with diabetes compared with control subjects. Neither whole-body ablation of MG53 nor sustained elevation of MG53 in circulation altered insulin signaling and glucose handling in db/db mice. Instead, mice with ablation of MG53 were more susceptible to streptozotocin-induced dysfunctional handling of glucose compared with the wild-type littermates. Alkaline-induced corneal injury demonstrated delayed healing in db/db mice, which was restored by topical administration of recombinant human (rh)MG53. Daily intravenous administration of rhMG53 in rats at concentrations up to 10 mg/kg did not produce adverse effects on glucose handling. These findings challenge the hypothetical function of MG53 as a causative factor for the development of diabetes. Our data suggest that rhMG53 is a potentially safe and effective biologic to treat diabetic oculopathy in rodents.
The Use of a Smart Bolus Calculator Informed by Real-time Insulin Sensitivity Assessments Reduces Postprandial Hypoglycemia Following an Aerobic Exercise Session in Individuals With Type 1 Diabetes
Authors: Fabris Chiara , Nass Ralf M. , Pinnata Jennifer , Carr Kelly A. , Koravi Chaitanya L.K. , Barnett Charlotte L. , Oliveri Mary C. , Anderson Stacey M. , Chernavvsky Daniel R. , Breton Marc D.
Published: March 2020

OBJECTIVE

Insulin dosing in type 1 diabetes (T1D) is oftentimes complicated by fluctuating insulin requirements driven by metabolic and psychobehavioral factors impacting individuals’ insulin sensitivity (IS). In this context, smart bolus calculators that automatically tailor prandial insulin dosing to the metabolic state of a person can improve glucose management in T1D.

RESEARCH DESIGN AND METHODS

Fifteen adults with T1D using continuous glucose monitors (CGMs) and insulin pumps completed two 24-h admissions in a hotel setting. During the admissions, participants engaged in an early afternoon 45-min aerobic exercise session, after which they received a standardized dinner meal. The dinner bolus was computed using a standard bolus calculator or smart bolus calculator informed by real-time IS estimates. Glucose control was assessed in the 4 h following dinner using CGMs and was compared between the two admissions.

RESULTS

The IS-informed bolus calculator allowed for a reduction in postprandial hypoglycemia as quantified by the low blood glucose index (2.02 vs. 3.31, P = 0.006) and percent time <70 mg/dL (8.48% vs. 15.18%, P = 0.049), without increasing hyperglycemia (high blood glucose index: 3.13 vs. 2.09, P = 0.075; percent time >180 mg/dL: 13.24% vs. 10.42%, P = 0.5; percent time >250 mg/dL: 2.08% vs. 1.19%, P = 0.317). In addition, the number of hypoglycemia rescue treatments was reduced from 12 to 7 with the use of the system.

CONCLUSIONS

The study shows that the proposed IS-informed bolus calculator is safe and feasible in adults with T1D, appropriately reducing postprandial hypoglycemia following an exercise-induced IS increase.
Implementasi Model Pembelajaran Problem Solving Untuk Meningkatkan Motivasi Belajar Dan Hasil Belajar Pkn Siswa
Authors: Putus Sasrini Ni Kadek
Published: March 2020

This study aims to ( 1 ) increase students' motivation to learn civics and ( 2 ) improving student learning outcomes of the implementation of civic education learning model of Problem Solving in learning  civics . The subjects were VI  grade students of SD Negeri 6 Tianyar in the second semester of academic year 2016/2017 , amounting to 35 men with 20 men and 15 women . This research was conducted in two cycles of learning with the stages in each cycle includes planning , action , observation / evaluation , and reflection . The data were collected by the method of student motivation questionnaire and student learning outcomes data collected through charging student worksheets ( LKS ) , tasks, quizzes , and a final test cycle . The collected data were then analyzed descriptively . Results showed ( 1 ) an increase in the average score of student learning moivasi at 87.80 on the first cycle and the second cycle increased to 92.74 , ( 2 ) an increase in civics student learning outcomes in the first cycle was 76.8 with complete categories and on the second cycle increased to 80.7 with complete categories.
Review and Analysis of Various Composite Propeller Shaft
Authors: Prakash Ravi , Patel Arun
Published: March 2020

The replacement of conventional steel driveshaft of automobiles with an appropriate composite driveshaft with different combinations of fibers at a time. For reducing the bending natural frequency the conventional steel shafts are made in two pieces, where to reduce the overall weight the composite material drive shaft is made in single piece. Various composites can be designed and analyzed for their appropriateness in terms of torsional strength, bending natural frequency and torsional buckling by comparing them with the conventional steel driveshaft under the same grounds of design constraints and the best-suited composite will be recommended. Light has been thrown upon the aspects like mass saving, number of plies and ply distribution.
Review on Optimising Solar PV Efficiency by Using Tracking and Cooling System
Authors: Khatri Anil , Tenguria Prof. Nitin
Published: March 2020

The increasing energy demand, continuous drawback of the existing sources of fossil fuels and increasing concern about environmental pollution pushed researchers to explore new technologies for the production of electricity from clean sources, renewable such as solar, wind etc. Solar energy is the oldest primary source of energy. It is a source of clean, renewable energy and it is found in abundance in every part of the world. Using solar energy is possible to convert it into mechanical energy or electricity with adequate efficiency. In this paper of the present of principal of solar cell and the temperature effect. And the Information about the quality and amount of solar energy available at a specific location is of prime importance for the development of a solar energy system. However, the amount of electricity that is obtained is directly proportional to the intensity of sunlight falling on the photovoltaic panel.
«Poesía completa», de Josefina de la Torre
Authors: Martín Fumero José Manuel
Published: March 2020

Reseña de la obra Poesía completa (ed. de Fran Garcerá, Madrid, Ediciones Torremozas, 2020, 2 vols.), de Josefina de la Torre.
Transfering Industrial and Commercial Property Rights to the Heirs in Jordanian Law
Authors: Al-Hendi Noor Issa
Published: March 2020

This study deals with the issue of the transferring of industrial and commercial property rights to heirs in Jordanian law, through counting and limitation the moral rights and financial rights of industrial and commercial property, and indicating the possibility of their transfer to the heirs or not, by standing on the industrial property represented in the patent, Industrial Designs. In addition, industrial property represented trademarks, trade secrets, and designs for integrated circuits, plant varieties and geographical indications.
The Very short story and Reductionism
Authors: Al Lawati Ehsan Sadiq
Published: March 2020

It managed a very short story, in recent decades, to assume for itself , especially in the narrative arts circle in contemporary Arabic literature, surpassing the problems and questions that coincided with the start of their appearance, such as: the label of conventional, first  roots, nationality and identity status (of the facial of sex Literary). The Arab writings in this field are prominent and present in the literary cultural scene in the various Arab countries. This clear development needs, in its continuity and the accuracy of its path, a monetary effort that accompanies it, as other literary races have previously needed such an effort. This study comes to deal with an aspect that may seem closer to the formal form of art, but in fact related to the substantive aspect as well, the reduction aspect of the story is very short, where does this reduction?  What are the most prominent manifestations?  And how to achieve this writing poetry without leaving it from being a prose?  What is its relationship in linking the content and form of the single literary text? These and other questions are being tried in an empirical manner, presenting examples of the very short story in Oman, written by some contemporary writers of the younger generation .
Psicoanálisis y Género: debates actuales y nuevas construcciones subjetivas
Authors: Meler Irene
Published: March 2020

El presente artículo se propone examinar críticamente la intersección entre los estudios interdisciplinarios de género y las teorías psicoanalíticas sobre el psiquismo y la subjetividad. Se realiza un recorrido por los diferentes modos en que la condición femenina ha sido considerada conceptualmente en el marco de diversas miradas disciplinares que hoy, retrospectivamente, integran una genealogía de los feminismos que acuden a la categoría de género, en diálogo con el psicoanálisis. Luego de explorar el vínculo ambivalente y conflictivo entre miradas de género y perspectivas psicoanalíticas, se ofrece un examen de los nexos entre las categorías de cuerpo, psiquismo y condición social de los sujetos.
MENINGKATKAN KEMAMPUAN MOTORIK HALUS ANAK USIA 5-6 TAHUN MELALUI KEGIATAN KOLASE DENGAN BAHAN BULU AYAM DI TK TUNAS HARAPAN TENGGARONG SEBERANGTAHUN PEMBELAJARAN 2016/2017
Authors: Darwati Darwati - , Hanita Hanita -
Published: March 2020

It is important for young learners to develop their sensory motor skill since it influences their skill in daily activities. However, in Tunas Harapan Kindergarten Tenggarong Seberang, the researcher observed that students aged 5-6 years old have low sensory motor skill such as in activities of writing, drawing, and coloring. Therefore, the researcher conducted a classroom action research in Tunas Harapan Kindergarten to find out the effectiveness of collage activity with bird’s feather as the learning median to improve the students’ sensory motor skills. In this study, as the learning media, the researcher did not only use bird’s feather, but also some materials which easily found around the countryside. As the research subjects, the researcher involved twenty students of group B, consisting of twelve males and eight females. Moreover, the data was collected during January to February 2017 by employing observation guide and documentation. Based on the result of research, it is found significant difference on average scores between cycles, before and after the treatment. At cycle I, the students’ sensory motor skill increased at 62.5% which classified in fair category. In addition, at the second cycle, the percentage went up into 75% which classified in good category. In conclusion, collage activity influenced students’ sensory motor skill. Therefore, it is suggested for teachers to provide stimulation and practices to increase students’ sensory motor skill by using various materials.
PENGARUH STANDART SARANA DAN PRASARANA TERHADAP EFEKTIFITAS PEMBELAJARAN DI TK AL-FIRDAUS
Authors: Kurniawan Nurhafit -
Published: March 2020

This research entitled "Influence standard of facilities and infrastructure to the effectiveness of learning in Kindergarten Al-Firdaus "the problem discussed in this research is how much influence the means of prasana to KBM process that exist in kindergarten Al pardaus, purpose of this research to know influence of facility and infrastructure to effectiveness KBM TK Al Firdaus. Methods in the study using descriptive correlational analysis, Vareabel Implementation of Standard Means and Infrastructure (X) is one of the resources that must be managed and improved continuously along with the development of science and technology, Vareabel Learning Effectiveness (Y) a deliberate, purposive, and controlled effort in order for others to learn or relative permanent change in others / or institution / kindergarten Alfirdaus, data processing in this study using statistical methods assisted excel program 2007 and SPSS 17.0. Based on the results of research data obtained through a questionnaire-shaped instrument, then given a score on each alternative answers given by the respondent in accordance with the weight that has been set. Each statement in the three variables has 5 answer criteria with scoring starting from 1, 2, 3, 4, and 5 with terms for statements calculated with the results of descriptive calculations. Classroom conditions in kindergarten Al-Firdaus 13.33% - 26.67% in lightly damaged condition, while the rest is very suitable to use. Learning media such as props, learning etc. are also complete, which is very concerned is the school computers that achieve 40-60% damage even more inadequate amounts are also specifications that lag far behind. Based on the research results can be concluded that one effort that can be done to improve the Effectiveness of Learning in kindergarten Al Firdaus is by improving facilities and infrastructure.