bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizing the Differential Health Burdens of Poor Water Quality in the Global South
Authors: OLUWASANYA Grace , OMONIYI Ayodetimi , QADIR Manzoor , MADANI Kaveh
Published: August 2024

Safe water is crucial for human health and sustainable development, yet unsafe water disproportionately affects vulnerable populations such as women, infants, and children. Targeting the Global South, where most of the world's population resides, this study combines a systematic literature review and a health risk assessment to examine the gendered health consequences of unsafe water. A systematic review of 73 peer-reviewed articles from 2015–2022, onset to midway the UN Sustainable Development Goals (SDG) era, highlighted Nitrate (40%), fluoride (33%), and arsenic (16%) as the most reported water contaminants in the Global South. Fluoride and arsenic were selected for detailed health risk analysis based on the reporting frequency and global data availability. The results show that infants, children, and pregnant women face higher health risks from water contaminants. Women are more susceptible to endocrine-disrupting chemicals and enteric pathogens, while men have slightly higher non-carcinogenic health hazard quotients from fluoride and arsenic exposure. Despite low fluoride HQs in most countries, several nations in South America and Asia showed high arsenic HQs, indicating elevated risks of arsenicosis, cancers, and neurological disorders. The study underscores the need to address the gendered impacts of water quality decline, recognizing that water-related issues are not gender-neutral. Holistic policies incorporating gender-sensitive water quality monitoring, tailored public health initiatives, WASH infrastructure development, and inclusive community engagement are crucial for equitable access to safe water. Such aspects contribute to achieving the UN Sustainable Development Goals (SDGs) related to health, gender equality, and reducing inequalities.
A Bibliometric Analysis in Publications of Neural Tube Defects in Latin America from 2000-2023
Authors: Vilca-Salas Martha I. , Rios-Garcia Wagner , Salas Marcos T. Vilca , Paucar-Anccasi Angie Andrea , Garcia-Sandoval Flavio Anghelo
Published: August 2024

Background
Neural tube defects (NTD) are one of the most common congenital defects in the world and have a high prevalence in low-income regions like Latin America. Despite their prevalence, research output on NTDs in Latin America is limited due to inadequate policies and investment in research. We present a bibliometric analysis of scientific publications on NTDs in Latin America from the year 2000 to 2023.
Methods
This bibliometric analysis examines scientific publications on NTDs in Latin America from 2000 to 2023, utilizing the Scopus database. Articles were selected based on their relevance to NTDs and the affiliation of at least one author to a Latin American institution. Data analysis was conducted using R's bibliometrix package and VOSViewer for visual analysis.
Results
A total of 722 articles were identified, primarily published in English (78.95%), with Brazil, Mexico, and Chile being the countries with most publications. The institutions with more publications were primarily located in Brazil, with the University of Sao Paulo being the top contributor. Collaborative networks were strongest between Brazil and the United States. The journal with highest quantity of publications was "Child’s Nervous System". The average number of citations per article was 13.51, with studies on folic acid fortification and genetic factors being the most cited.
Conclusions
This study provides a comprehensive overview of NTD research in Latin America, emphasizing the importance of regional risk factors and prevention policies.
Atypical Hemolytic Uremic Syndrome, a Possible Leukocyte Extravasation Disorder, case report and review of literature
Authors: Zsidisin George Nicholas
Published: August 2024

Using specific clinical analyses, including genetic, hemolytic, and blood, an in-depth review of the research and disease manifestations leads to a unique hypothesis about our patient’s atypical hemolytic uremic syndrome pathophysiology. Notably, a novel C3 defect, in addition to a common factor B mutation, leads to doubt over current theories of alternative complement overactivation and further drives focus onto the thrombotic nature of the disease. We propose a pathology of defective platelet-leukocyte-endothelial adhesions, leading to poor leukocyte extravasation.
Unveiling Hidden Risks: Obstetrical Complications in Endometriosis Associated Infertility Post-Laparoscopic Surgery
Authors: Lin Shunhe , Chen Qingshan , Liu Chaobin , Lin Guan , Huang Penghui , Qi Wei , Xie Xi , Wang Zhenna , Guo Yuyan
Published: August 2024

Objective
This study aims to elucidate the spectrum of obstetrical complications in patients with endometriosis-associated infertility following complete laparoscopic excision of endometriosis lesions, and to assess the impact of endometriosis severity on these outcomes.
Study design:
This case-control study enrolled 151 women who underwent laparoscopic surgery for endometriosis-associated infertility at Fujian Maternity and Child Health Hospital between January 2014 and September 2020, and who subsequently gave birth to a singleton at the same hospital by September 2021. Participants were divided into a stage I–II endometriosis group (n = 88) and a stage III–IV endometriosis group (n = 63). A control group consisted of 302 women without endometriosis who delivered a singleton at the same hospital during the same period. Clinical data and complications during pregnancy, delivery, and the neonatal stages were collected from the hospital’s medical record system.
Results
After adjusting for confounding factors, women in the stage I–II endometriosis group had a significantly higher risk of gestational diabetes mellitus (GDM) (P = 0.004) and cesarean section (P = 0.027) compared to the control group. Women in the stage III–IV endometriosis group exhibited a higher risk of GDM (P = 0.048) and premature rupture of membranes (P = 0.039). No statistically significant differences were observed in other obstetrical complications between the endometriosis and control groups.
Conclusions
Women with a history of stage I–II endometriosis who have undergone laparoscopic conservative surgery face a higher risk of GDM and cesarean section during pregnancy. Those with a history of stage III–IV endometriosis are at an elevated risk of GDM and premature rupture of membranes. These findings underscore the need for heightened monitoring and management of pregnancies in women with prior endometriosis.
Research on the development level and technology-driven efficiency of the intelligent international shipping center development
Authors: lianhua liu , Shiqi Lyu , Zexian chen , xiu chen
Published: August 2024

Firstly, this paper introduces a new concept of intelligent international shipping center, and its characteristics are: ① intelligent shipping industry technology; ② knowledgeable shipping service; ③ intelligent shipping industry chain. Secondly, the paper constructs an evaluation model for the development capacity of intelligent international shipping centers, and evaluates the seven major international shipping centers in Guangzhou, Hong Kong, Shenzhen, Shanghai, Tianjin, Dalian and Lianyungang. The empirical results show that the development capacity of the major international shipping centers has been improved with the passage of time, among which, Shanghai's development ability has always been in the lead, and some international shipping centers lack of potential of continuous development. We need to consider the input factors. Then, further discusses the impact of technology input factors on the development of international shipping center. This paper uses DEA combined with Malmquist index to study, and the results show that technological progress is the main driving force to promote the development of international shipping cente. Finally, this paper puts forward three suggestions for improvement:①pay attention to the application of new technology to improve the intelligent level,Focus on the application of new technologies.②promote the knowledge transformation of shipping business and improve the intelligent ability.③integrate the upstream and downstream shipping industry and coordinated development of the shipping industry ecosystem.
Comprehension for Breast Awareness, Dense Breast, and Hereditary Breast and/or Ovarian Cancer (HBOC) in participants of Breast Cancer Screening
Authors: Nakagomi Hiroshi , Teramoto Katsuhiro , Nakada Haruka , Matsuda Kei , Yoneyama Ryoko , Kawai Chiemi , Miura Yoshinari , Kunugi Chiemi , Hirose Junji , Yoda Yoshioki
Published: August 2024

Background: It is important to promote breast awareness (BA) as an alternative to breast self-examination in order to improve the prognosis of breast cancer patients.
Methods: We investigated the level of comprehension for BA among participants of the organized (n=7959) and the opportunistic (n=11541) breast cancer screening. In addition, we investigated the level of comprehension for dense breast (DB) and hereditary breast and/or ovarian cancer (HBOC) as knowledge necessary for optimal breast cancer screening.
Results: The overall percentages of comprehension of BA, DB and HBOC were 24, 32, and 24%, respectively. The level of comprehension of BA, DB, and HBOC was lower among participants aged <49 years compared to those aged >50 years. First-time participants were less likely to be aware of BA, DB, and HBOC than those who had screening for the second time or more. On the other hand, there was no difference in the level of comprehension of BA between organized and opportunistic screening, but the level of awareness of BD and HBOC was significantly higher in participants of opportunistic screening.
Conclusions: The level of comprehension for BA, DB and HBOC is still low in 2023. Our results indicates that screening is an important opportunity to educate something about the breast health literacy. We intend to conduct this survey and educational campaign over time to determine if those comprehension improve.
Establishment and characterization of a new mouse gastric carcino-ma cell line, MCC
Authors: Wang Yushen , Li Xianju , Wang Yi , Qin Jun
Published: August 2024

Background
The aim of this study was to establish a primary mouse gastric carcinoma cell line.
Methods
Gastric adenocarcinoma in the body region was induced in immunocompetent BALB/c mice using N-Methyl-N-nitrosourea and a 2% NaCl solution. Fresh gastric cancer tissue samples were cultured in 1640 medium supplemented with 10% fetal bovine serum for primary culture and subculture. Cellular morphology was assessed via light microscopy, and a cell growth curve was established. Genomic and proteomic analyses were conducted to characterize the molecular features of the cell lines. This cell line demonstrated a 100% success rate in forming subcutaneous tumors in BALB/c mice. By integrating proteomic profiles from clinical gastric cancer patients and the murine subcutaneous tumor model, several molecular targets suitable for preclinical investigation were identified. Trametinib, a MEK inhibitor, was employed as a model compound in our preclinical study.
Results
A novel gastric carcinoma cell line, designated MCC, was established from BALB/c mice. This cell line exhibited a doubling time of approximately 33 hours. Genomic and proteomic analyses identified mutations frequently observed in clinical gastric cancer patients, such as Kras, Egfr, and Ccnd3. Additionally, MCC overexpresses proteins, including SLC1A5, MCC6, and ITGA2, which are significantly upregulated in gastric cancer tissues compared to adjacent non-cancerous tissues. The MCC cell line demonstrated stable tumorigenicity in immunocompetent BALB/c mice, forming subcutaneous tumors that closely resemble the proteomic profile of clinical gastric cancer samples. This high concordance facilitated the identification of several potential therapeutic targets for gastric cancer. Preclinical studies with trametinib revealed that treatment effectively inhibited gastric cancer growth, likely mediated through the activation of immune cells, particularly neutrophils and T cells.
Conclusions
The MCC cell line is a valuable tool for gastric cancer research, enabling studies of cancer development, progression, and metastasis, and providing a robust platform for evaluating therapeutic strategies and drug efficacy. Its strong tumorigenicity and high correlation with clinical proteomic profiles underscore its relevance in translational research, aiding in the identification of novel therapeutic targets and molecular pathways for effective treatments.
High CD38 expression defines a mitochondrial function adapted CD8 + T cell subset with implications for lung cancer immunotherapy
Authors: Lv Leilei , Zhai Jia-wei , Wu Jia-juan , Fan Gui-qin , Zhang Yao-xin , Shen Yu , Qu Qiu-Xia , Chen Cheng
Published: August 2024

Despite identifying specific CD8+T cell subsets associated with immunotherapy resistance, the molecular pathway triggering the process remains elusive. Given the potential of CD38 in regulating CD8+T cell function, we aimed to observe the accumulation of CD38+CD8+T cells in lung cancer and further explored its role in immunotherapy resistance. Phenotypic analysis of tumoral CD8+T cells from both lung cancer patients and immunotherapy-resistant pre-clinical models identifies that CD38-expressing CD8+T cells displayed as CD38hi and CD38intT cell subsets. Following, it was observed a higher expression of CD38 along with T cell exhaustion genes and dysregulated mitochondrial bioenergetics. In addition, it was suggested that an evaluated CD38hiCD8+T cells in peripheral but not in center of TME were associated with good response to anti-PD-1 therapy in NSCLC, as well as corresponding depth of clinical regression, which was evidenced by more depletion of CD38hiCD8+T cells occur in subject with higher regional CD38hiCD8+T cells infiltration. As expected, it was found that ICIs-resistant murine lung cancer models had lack of effective reduction in term of CD38hiCD8+T cells when receiving PD-L1 mAb alone. Notably, combination therapy of PD-L1 mAb and EGCG could selectively restrict CD38hiCD8+T cells infiltration and enhance IFN-γ production by these T cells, thereby significantly improved survival in this carcinoma model. This restored immunotherapy sensitivity was found to be related to the selective improved mitochondrial of CD38hiCD8+T cells, which was validated by the established link between IFN-γ production and mitochondrial metabolism. Collectively, our data highlighted a role for the CD38-coupled dysfunctional mitochondrial in promoting CD8+T cell exhaustion and intrinsic resistance to ICIs therapy, thereby offered a rationale target to enhance the therapeutic efficacy of PD-1 blockade therapy in lung cancer.
Oriental Stock Prediction Approach(OSPA): A Model for Stock Price Prediction Utilizing the Capacity of Time Series Analysis
Authors: Verma Pawan , Kumar Mohit , Verma Sahil , Gulhane Monali , Rakesh Nitin , Jhanjhi NZ , Khurma Ruba Abu , Shah Mohd Asif , Mallik Saurav
Published: August 2024

This paper delves into the intricate world of financial markets, where accurate prediction of stock prices plays a pivotal role in guiding investment strategies and financial decision-making. In an era dominated by vast amounts of data, the application of advanced time series analysis models has become increasingly critical for extracting meaningful insights from market trends. This paper explores the efficacy of various deep learning models, including Long Short-Term Memory (LSTM), Bidirectional LSTM (BiLSTM), Gated Recurrent Unit (GRU), and an enhanced version of GRU (Improved GRU), in predicting stock prices. Through rigorous evaluation, the paper demonstrates that the Improved GRU model outshines its counterparts in forecasting accuracy, as evidenced by its superior performance across multiple evaluation metrics such as Mean Squared Error, Mean Absolute Error, Root Mean Squared Error, and R-squared Score. The implications of these findings are vast, suggesting that the Improved GRU model can serve as a powerful tool for investors and financial analysts seeking to navigate the complexities of the stock market with greater precision. Furthermore, the study opens up new avenues for future research, emphasizing the need for further enhancements in prediction models through the integration of more granular data sources, exploration of hybrid models, and the application of machine learning techniques to understand the multifaceted dynamics of financial markets better. This paper not only advances our understanding of stock price prediction models but also sets the stage for the development of more sophisticated and accurate forecasting tools in the field of financial time series analysis.
Potential of Rice Husk Bio-char as a Sustainable Soil Fertilizer Alternative
Authors: Yusop Nur Aqidah Mat , Md Umi Fazara , Ahmad Syahirah Faraheen Kabir
Published: August 2024

This study was conducted to test the effectiveness of biochar rice husk as an alternative fertilizer for the growth of mustard greens. There are four treatments used in this experiment, where CK is the control, BRH10 is rice husk biochar with 10% mixing rate (w/w), BRH30 is rice husk biochar with 30% (w/w) mixing rate and BRH50 is rice husk biochar with 50%(w/w) mixing rate. There are two types of soil used in the study labelled as Soil A (silty loam soil) and Soil B (sandy clay loam). Several analyses have been done to identify the suitability of biochar to be used as soil fertilizer including determining functional groups, morphology, pH, elements, height and weight. The results of the study showed that the crop yield obtained for height and weight measurement in the BRH10 treatment is the best, which is 7.9 cm and 0.4477 g. Based on the results of soil pH, SEM analysis and elemental analysis, it showed that the biochar is suitable for the cultivation of mustard greens and showed the ability to increase soil fertility. In conclusion of this study is that the BRH10 treatment for soil B has a better effect on the growth of mustard green plants compared to soil A and other treatments. Therefore, this biochar rice husk is suitable as an alternative fertilizer but should be used in less quantities.
Learnings from Conducting Online Surveys in India During the COVID-19 Pandemic
Authors: Kashyap Shubhangi , Velleman Richard , Singh Soumya , D’Souza Ethel , Gaikwad Leena , Bhatia Urvita , Nadkarni Abhijit
Published: August 2024

When traditional research data collection methods were stalled due to the COVID-19 driven large-scale lockdown across India, it led to a sharp rise in the use of digital platforms to collect research data. In 2020, we launched three online surveys (including cross-sectional and longitudinal surveys) aimed at understanding the mental health concerns and needs of different populations in India. This paper presents the learnings from conducting these surveys and highlights the experience of our team with respect to different phases of the studies such as conceptualisation, development, recruitment, and dissemination. Our key findings are that: collaboration with relevant organisations was the most effective method for mass dissemination and recruitment; despite an aim of wide recruitment, survey recruitment came primarily from known networks; if aiming for recruitment via significant social media dissemination, then translation into regional languages was not effective on its own; and the visual design, user interface, and ease of language play a key role in making the survey accessible, inclusive, and easy to navigate. Based on these learnings, we present recommendations for the planning and execution of online surveys in low-resource settings.
Physical and Cognitive Performance Impairment with Cannabis Consumption in Adults Over 12 hours
Authors: Abu-Ashour Waseem , Wahl Michael , Anvar Saman Hadjizadeh , Bahrami Mohammadmahdi , Zahiri Ali , Aragão-Santos Jose Carlos , Weber John T. , Behm David G
Published: August 2024

Background
Assessing the impact of cannabis on cognitive and physical performance is imperative, especially in safety-sensitive environments. This study investigated the degree and duration of performance impairment after cannabis consumption.
Methods
Fourteen cannabis users were subjected to physical and cognitive testing before and after smoking cannabis. Tests included assessment of intoxication, vital signs, psychomotor abilities, and muscle function. Blood, urine and saliva were analyzed for Delta-9-tetrahydrocannabinol (THC) and Carboxy-THC at baseline, and 1-, 6-, and 12-hours post-consumption.
Results
Blood THC levels peaked significantly at 1 hour and declined by 6 hours (p < 0.001), whereas Carboxy-THC levels showed a less pronounced but consistent variation over time (p = 0.005). Urine Carboxy-THC levels displayed a non-significant similar trend (p = 0.068). Acute cannabis use significantly (p = 0.01 – p < 0.001) raised systolic blood pressure and heart rate, increased force variability, reduced rate of force development, and compromised balance and muscle endurance up to 12 hours post-consumption.
Conclusions
Acute cannabis consumption results in physical impairments, impacting essential functions required for safety-sensitive tasks. The sustained presence of Carboxy-THC indicates prolonged pharmacological effects and necessitates cautious policy-making for workplaces.
Trial Registration
This study was not registered as a clinical trial as the ClinicalTrials.gov indicates that the study must answer yes to all four questions on their checklist. Although, our study was interventional, it was not conducted in the US nor involved a new FDA investigational new drug application, and the cannabis was not manufactured or exported from the US. The focus of the study was on the recreational use of a single cannabis cigarette on subsequent physiological or work performance and safety measures over 12 hours.
Between Walls and Wilds: Myocastor coypus Abundance and Ocurrence in Gated and Open Communities Buenos Aires, Argentina
Authors: Araos Florencia Abdenur , Cavia Regino , Corriale María José
Published: August 2024

Urban development changes landscapes and creates new environmental conditions, causing local wildlife to either become extinct or expand to new areas. An example is the Myocastor coypus, are increasingly establishing themselves in urban habitats, even within its natural distribution range. This species has the potential to impact crop production and natural vegetation, generating conflicts with humans. In the Conurbano Bonaerense, the construction of gated communities creates new niches for this species. This study aimed to analyze how the main characteristics of urban developments in the Conurbano Bonaerense (type of urbanization and water body and geographical location) are associated with the abundance and occurrence of M. coypus. Sampling was conducted during 2021–2022 and 2022–2023 in the peak activity season of the species, in open and gated communities across the Conurbano Bonaerense, covering approximately 3,680 km². The presence of the species and its signs of activity were recorded in 331 transects along streams and ponds at 24 sampling sites evenly distributed. The occurrence and abundance were higher in gated communities (p < 0.05). Furthermore, the occurrence of the species was higher in lentic water bodies compared to lotic water bodies (p < 0.05). The probability of the species reaching pest levels per transect was 0.62 (95% CI = 0.26–0.98) of gated communities, while in open communities, it was only 0.1 (95% CI = 0-0.2). These results emphasize the need for a multidisciplinary approach to develop management strategies and deepen the study of the species ecology at a local level.
Assessing GPT and DeepL for Terminology Translation in the Medical Domain: A Comparative Study on the Human Phenotype Ontology
Authors: NOLL Richard , BERGER Alexandra , KIEU Dominik , MUELLER Tobias , BOHMANN Ferdinand , MÜLLER Angelina , HOLTZ Svea , STOFFERS Philipp , HOEHL Sebastian , GUENGOEZE Oya , ECKARDT Jan-Niklas , STORF Holger , SCHAAF Jannik
Published: August 2024

Background
This paper presents a comparative study of two state-of-the-art language models, OpenAI's GPT and DeepL, in the context of terminology translation within the medical domain.
Methods
This study was conducted on the Human Phenotype Ontology (HPO), which is used in medical research and diagnosis. Medical experts assess the performance of both models on a set of 120 translated HPO terms, employing a 4-point Likert scale (strongly agree = 1, agree = 2, disagree = 3, strongly disagree = 4). An independent reference translation from the HeTOP database was used to validate the quality of the translation.
Results
The average Likert rating for the 120 selected HPO terms was 1.29 for GPT-3.5 and 1.37 for DeepL. The comparison with HeTOP revealed a high degree of similarity between the machine translations and the reference translations.
Conclusions
The results indicate that both GPT and DeepL are effective at translating HPO terms from English to German. Statistical analysis revealed no significant differences in the mean ratings between the two models, confirming their comparable performance in terms of translation quality. The study not only illustrates the potential of machine translation but also shows incomplete coverage of translated medical terminology. This underscores the relevance of this study for cross-lingual medical research. However, the evaluation methods need to be further refined, and specific translation issues need to be addressed.
A New Model for the Hierarchical Response of Control Devices in the Power Flow Problem
Authors: Gatta Paula Oliveira La , Netto Nicolas Abreu Rocha Leite , Filho Joao Alberto Passos
Published: August 2024

Various control devices, such as shunt banks, on-load tap changers, and static var compensators, can be connected to a microgrid. Depending on the operating schemes, some of these controls may hierarchically actuate in the system to maintain reactive power reserve. This paper proposes a formulation based on sigmoid functions to perform the hierarchical actuation of control devices in the power flow problem. The methodology was generalized to accommodate N hierarchy levels, where N is the number of control devices. The sigmoid function deals with the operational device, and when it reaches its limits, it activates the performance of the subsequent one. To achieve this, the methodology incorporates equations obtained from combining the steady-state characteristics of the control devices and the sigmoid functions into the power flow formulation. These equations are solved simultaneously with the power flow equations in polar coordinates using the full Newton's method. The methodology is evaluated by applying it to two test systems: 11-bus test system and the well-known Nordic system. The results demonstrate the effectiveness of the proposed approach.
Influence of information asymmetry on the cost of equity capital in companies admitted to Tehran Stock Exchange
Authors: AskariNia Saeed
Published: August 2024

The purpose of this research is to investigate the effect of information asymmetry on capital structure and capital cost of companies accepted in Tehran Stock Exchange. For this purpose, four different criteria of cost of capital, including the cost of capital (WACC) stock, the cost of capital accumulated profits, the cost of debt and the average cost of capital, were analyzed. The statistical population of this study consisted of 94 companies from 20 different industrial groups that showed a significant relationship between information asymmetry and two criteria for the cost of capital stock and debt expenses in the period of 2004–2014 using combined data. But between information asymmetry and the other two criteria, the accumulated profit cost and the rationale for the cost of capital are not significant. Therefore, it can be said that the operational definition of cost of capital affects the existence or non-existence of the mentioned relationship.
A Machine Learning Framework for Early Detection of Cardiovascular Risk Using Diabetes-Related Indicators: A Predictive Modeling Data-Driven Research
Authors: Borges Julian
Published: August 2024

Background and Objectives: Cardiovascular disease (CVD) remains a leading cause of death worldwide, with early detection critical for effective intervention. Diabetes, especially in its early stages, shares many pathophysiological features with CVD, making it a significant predictor of cardiovascular risk. This study explores the relationship between early-stage diabetes symptoms and CVD risk by developing and evaluating predictive models using logistic regression and Random Forest algorithms.
Methods: The study utilized two publicly available datasets: the Early Stage Diabetes Risk Prediction Dataset and the Heart Failure Clinical Records Dataset, containing 520 and 299 instances, respectively. Data preprocessing included median imputation for missing values and binary conversion of categorical variables. Feature engineering involved creating a symptom severity score by summing key diabetes-related symptoms. Logistic regression and Random Forest models were trained on 80% of the data and tested on the remaining 20%.
Findings: The Random Forest model outperformed logistic regression, achieving an accuracy of 81.4%, an AUC of 0.88, and a balanced accuracy of 83.5%. Serum creatinine, ejection fraction, and age were identified as significant predictors of heart failure risk. Logistic regression achieved an accuracy of 76.3% and an AUC of 0.78. The performance difference between the models was statistically significant (p = 0.015).
Conclusion: Symptoms associated with early-stage diabetes can be effective predictors of heart failure risk, with Random Forest showing strong predictive performance. These findings highlight the potential of machine learning in early detection of high-risk patients, facilitating timely interventions.
ÜÇ FARKLI YAPIDAKİ CAD/CAM MATERYALLER İLE KOMPOZİT REZİNLER ARASINDA OLUŞAN BAĞLANTININ İNCELENMESİ
Authors: Angın Rümeysa , Tekçe Neslihan
Published: August 2024

Amaç: Üç farklı yapıdaki CAD/CAM materyallerle bu materyallerin tamirinde kullanılan akışkan/tepilebilir kompozit rezinler arasında oluşan bağlantı dayanımının değerlendirilmesidir.
Yöntem: IPS e.max CAD (Ivoclar), Cerasmart (GC), Vita Enamic (Vita Zahnfabric) CAD/CAM materyallerden (7×7×2 mm) hazırlanan örnekler, otopolimerizan akrilikle sabitlendi (n=10). Örneklerin üst yüzeyleri 600-1200 SIC zımparayla 60 sn zımparalandı. Örnek yüzeyleri yeşil kuşaklı elmas frezle 10 sn pürüzlendirildi. Hazırlanan CAD/CAM yüzeylere G-Aenial Posterior (GC) veya G-Aenial Universal Flo (GC) 2-mm yüksekliğinde üretici firma önerileri doğrultusunda uygulandı. Tüm CAD/CAM yüzeylerde silan olarak G-Multi Primer; bonding ajan olarak G-2 Bond Universal kullanıldı. Tüm CAD/CAM yüzeylerinde kompozitler bir teflon kalıp kullanılarak tepildi ve polimerize edildi. Örneklere bağlanma dayanım testi (Shear Bond Test) uygulandı. Örnek yüzeyleri stereomikroskop altında incelenilerek kırılma tipleri belirlendi. Başarısızlık tipleri adeziv/CAD/CAM koheziv/kompozit koheziv/miks olarak sınıflandırıldı. Veriler tek yönlü varyans analizi (ANOVA) ve Tukey HSD testi kullanılarak analiz edildi (P < .05). Kırılma tipleri Ki-kare testi kullanılarak değerlendirildi.
Bulgular: CAD/CAM materyaller arası kıyaslamada, Vita Enamic ve Cerasmart yüzeylerinde benzer bağlanma dayanım değerleri elde edildi, IPS e.max CAD’de ise diğer CAD/CAM materyallereden daha düşük bağlanma dayanım değerleri elde edildi. G-Aenial Posterior veya G-Aenial Universal Flo’nun CAD/CAM yüzeylere bağlanması arasında benzer değerler tespit edildi. Kırılma tipi değerlendirilmesinde, IPS e.max CAD materyalinde adeziv tipte kırılma, Vita Enamic ve Cerasmart materyalinde ise CAD/CAM koheziv tipte kırılmalar görüldü.
Sonuç: Tamirde kullanılan kompozit rezinlerin, rezin bazlı CAD/CAM materyallere bağlanması seramik yapıdaki CAD/CAM materyaline bağlanmadan daha iyidir. Her iki kompozit rezinde tamir prosedüründe kullanılabilir.
Sodyum Hipoklorite Maruz Kalan Nikel-Titanyum Eğelerin Döngüsel Yorgunluğuna Karşı Direnç Değişimi
Authors: Bodrumlu Emre , Obaid Abdullah A.m.
Published: August 2024

Amaç: Bu çalışmanın amacı, CE belgesi olan ve olmayan iki nikel-titanyum (NİTİ) döner eğenin ilk hali ile %5 sodyum hipoklorit (NaOCl) solüsyonlarına 5 dakika maruz kalan eğelerin döngüsel yorgunluk dirençlerindeki değişimleri değerlendirmektir.
Gereç ve Yöntemler: Bu çalışmada, 32 adet paketinden yeni çıkarılan CE belgesi olan ve olmayan 2 çeşit NiTi eğe (V3-M boyut 25.04 ve boyut 25.04 R-Shaper eğesi) kullanılmaktadır. Eğeler, CE belgesi olan ve olmayan şeklinde 16’şarlı gruplara ayrıldı. Bu gruplar da paketinden yeni çıkarılan eğe grubu ve steril etmek için 5 dakika %5 NaOCl’ye maruz bırakılmış eğe grubu olarak ikiye (n=8) ayrıldı. Eğelerin döngüsel yorulma direnci, özel olarak tasarlanmış bir test cihazında ölçüldü. Eğelerin döngüsel yorulma dirençlerini karşılaştırmak için SPSS 22.0 Paket Veri Programı (SPSS 22.0 Software Package Program, Inc., Chicago, IL, ABD) kullanıldı. Anlamlılık değeri p<0.05 olarak kabul edildi.
Bulgular: İki farklı eğe grubunun maruz kalmadan önceki ve sonraki döngüsel dayanımları karşılaştırıldığında, R-shaper eğesinde maruz bırakılmadan önceki ve sonraki değerler arasında anlamlı bir fark bulunmazken (p=0.74), V3-m tipi eğenin maruz bırakılmadan önceki ve sonraki değerleri arasında istatistiksel olarak anlamlı bir fark bulunmamıştır (p<0.05).
Sonuç: CE belgesine sahip olan NİTİ döner aletlerin döngüsel yorulma dirençleri, ilk hali ile steril etmek için %5 NaOCl'ye maruz bırakılan etkilenmemesine karşın CE belgesi olmayan eğelerin döngüsel dirençlerinde değişiklik göstermektedir. Bu nedenle CE belgeli NiTi eğelerinin kullanılmasının önem arz edeceği görüşündeyiz.
Pemodelan Tingkat Kemiskinan di Papua Barat dengan Pendekatan Binary Logistic Regression
Authors: Aini Anissa Nur , Octario Ashar Andika Udistiyan , Lestari Talia Indah , Nur Indah Manfaati , Wasono Rochdi
Published: August 2024

Binary logistic regression model is a regression model used to predict the probability of a specific event occurring or not occurring based on predictor variable. In this model, the response variable is binary, meaning it has only two possible categories: a “failure”category and a “success” category. West Papua is included in the list of  seven provinces that are the main focus of efforts to combat extreme poverty. Therefore, it is necessary to monitor the factors that need to be considered in order to prevent an increase in the poverty rate. To identify the factors influencing the poverty rate in Papua Barat, the research method used is binary logistic regression modeling, which assesses the influence of independent variables on the poverty rate in West Papua. So the results obtained from this study are from three variables, namely the open unemployment rate, average per capita expenditure, and gross regional domestic product have a significant effect on the poverty rate in West Papua with a classification accuracy of 100%.
Penyelesaian Metode Round Off dan Metode Cutting Plane dalam Optimalisasi Produksi Anyaman Rotan UD. Kirana
Authors: Safitri Elfira , Basriati Sri , Mexdika Raja Putra , Soleh Mohammad
Published: August 2024

UD Kirana is a trading business that produces rattan weaving in Rumbai district which consists of 5 types of products produced, namely guest chairs, terrace chairs, tender chairs, serving hoods and baskets. In the rattan woven production process, UD Kirana cannot predict how many items can be produced each week so that maximum profits have not been achieved.This research aims to find out how goods can be produced every week in order to get maximum profits.The methods used are the Round Off method and the Cutting Plane method. Based on the research result, UD Kirana produced 10 tender chairs, 7 serving hoods and 21 baskets with a profit of Rp. 6.060.000. The Round Off method is more efficient than the Cutting Plane method, this can be seen from the addition of constraints, namely the Round Off method adds two constraints and the Cutting Plane method adds three constraints or gomory constraints.
Analisis Kestabilan Lokal Model Transmisi Demam Berdarah Dengue
Authors: Diana Arista Fitri , Hajar Muhammad Ibnu , Ikhtiyar Zakaria Bani , Aulia Lathifatul
Published: August 2024

Dengue fever transmission in Indonesia has an advanced amount. In this article, dynamic model of interaction between human and Aedes aegypti mosquitos is learned. The SEIRRD (Susceptible, Exposed, Infected, Recovered, Deceased) model is used in this article. The prurpose in this model is to describe the stability of dengue transmission, so that we can analyze the developed of epidemic model in mathemtic field. Using NGM method to analyze basic reproduction number and applying Routh-Hurwitz criteria method to show the local stability of model. Then, two equilibrium points, called endemic and non-endemic equilibrium points, are obtained. The result of basic reproduction number is described the stability analysis. If basic reproduction number less then one, the endemic equilibrium point is locally asymptotically stable and otherwise. Local stability analysis at the equilibrium point is determined through parameter analysis. Furthermore, numerical simulations are carried out by fitting the data to obtaine the result of the parameters. The results of numerical simulations explaine the spread of dengue transmission Keywords: Dynamic Model, Epidemic Model, Equilibrium Point, Local Stability, Routh Hurwitz
Regresi Data Panel Indeks Pembangunan Manusia Provinsi Kepulauan Bangka Belitung
Authors: Yulianto Safa’at , Dwinda Dede
Published: August 2024

The Human Development Index (HDI) isused as tool to measure the success or failure of program aimed at improving the quality of human life. Itserves as determinant of the level of development of a country or region.. in this research, panel data is utilized in the form of a combination of cross-section and time series. This type of data can provide insights into two types of information: inter-unit and inter-time information. Panel data regression is a regression with a data structure in the form of data on the diversity of location aspects alone but also influenced by other factors. The purpose of this study was to determine the factors that affect the quality of life in the Bangka Belitung Islands Province. As a result of this study, the best panel data regression model uses the Random Effect Model (REM). Life expectancy variables, average years of schooling, expected years of schooling and per capita expenditure were able to explain HDI in the Bangka Belitung Islands Province by 99.80%. The panel data regression equations are  IPMit = 4.904 + 0,488 UHHit + 1,322 RLSit + 1,004 HLSit + 0,000 PPit.Keywords: HDI, Random Effect Model, Panel Data Regressioan.
Efficiency evaluation criteria of the model of the process of designing an didactic space for teachers in secondary schools
Authors: Selikhova Tatiana Yurievna
Published: August 2024

The article deals with the main components of the model of the process of designing the didactic space of the teacher with the help of in-house training of the teaching staff of the school. Criteria and indicators of efficiency of the offered model are defined. The proposed diagnostic tools allow to fix external and internal changes in the professional activity and in the semantic sphere of the teacher, as well as qualitative changes in the students with whom the teacher works. A level approach to assessing the formation of the didactic space of the teacher on the set of indicators of the proposed criteria is proposed.
Analysis of the level of physical training of student youth in the higher educational institution
Authors: Nikolaev Roman Iurevich
Published: August 2024

The article discusses the causes of problem adaptation to the requirements of the educational standard of higher education in physical culture. The analysis of the development of individual physical qualities of physical fitness in the annual cycle of study and during the period of study in higher education is given.
Studying the needs of social groups as a factor of perfection of management of hotel activities
Authors: Voinova Natalia Evgenevna , Apukhtina Natalia Vladimirovna
Published: August 2024

Questions of management of hotel activity based on provisions of modern social policy in Russia are considered in the work. Support of social tourism within realization of social policy of the state can provide to hotel business additional segments of the market. Segments can be such social groups as youth, the elderly, persons with disabilities. Studying the needs of these social groups will help the hotel business to develop a competent management strategy.
Key factors affecting the drop in labor productivity, as a consequence the production of low-quality products in the enterprise aerospace industry
Authors: Zakharenko Egor Glebovich
Published: August 2024

The key factors having an impact on decline in production of work and falling of level of quality of products in the aerospace industry are considered in the article. The analysis of dynamics of development of the aerospace industry is carried out, the statistical data characterizing position of the Russian aviation industry on the world scene are provided. Loudspeakers of the index of labor productivity are analyzed, its influence on quality of products of the industry is estimated. Interrelations are revealed and proved, the tendency to improvement of the situation in the industry is planned.
Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer
Authors: Zhang Yuzhe , Yan Lirong , Liu Aoran , Li Fang , Li Yanke , Zhang Ye
Published: August 2024

Background:

PTK7 (Protein Tyrosine Kinase 7), a member of the receptor
protein tyrosine kinase family, was originally discovered in colon cancer cells. It plays a
pivotal role in numerous developmental and physiological processes, particularly in the
regulation of cell polarity. Despite accumulating evidence of PTK7's significant influence
on tumor development, a comprehensive pan-cancer analysis of PTK7 has yet to be
conducted.

Methods:

We conducted a comprehensive analysis of PTK7's expression, prognostic value,
and mutational patterns across various tumor types. We further explored the correlations
between PTK7 expression and tumor stemness, immune-related genes, immune
scores, and immune cell infiltration.

Results:

Enrichment analysis revealed PTK7's critical involvement in pan-cancer functions
and processes, including the WNT pathway, Epithelial-Mesenchymal Transition
(EMT), and cell polarity regulation. Additionally, we validated PTK7's expression in
gastric cancer via immunohistochemistry.

Conclusion:

Our study indicates that PTK7 holds promise as an ideal pan-cancer biomarker
due to its involvement in tumor progression and tumor immunity.
Catalase: A Potential Pharmacologic Target for Hydrogen Peroxide in the Treatment of COVID-19
Authors: Urakov Aleksandr , Urakova Natalya , Reshetnikov Aleksey , Shklyaev Aleksey , Nikolenko Vladimir , Osipov Anatoly , Klyachko Natalya , Sorokina Yulia , Muhutdinov Nikita , Okovityi Sergey , Shabanov Petr
Published: August 2024

Background:

Acute respiratory distress syndrome in the elderly with COVID-19 complicated
by airway obstruction with sputum and mucus, and cases of asphyxia with blood, serous
fluid, pus, or meconium in newborns and people of different ages can sometimes cause hypoxemia
and death from hypoxic damage to brain cells, because the medical standard does not include
intrapulmonary injections of oxygen-producing solutions. The physical-chemical repurposing
of hydrogen peroxide from an antiseptic to an oxygen-producing antihypoxant offers hope for
the development of new drugs.

Methods:

This manuscript is a meta-analysis performed according to PRISMA guidelines.

Results:

It is shown that replacement of the traditional acidic activity of hydrogen peroxide solutions
by alkaline activity with pH 8.4 and heating the solutions to the temperature of +37 - +42 °C
allows to repurpose hydrogen peroxide from antiseptics into inhalation and intrapulmonary mucolytics,
pyolytics and antihypoxants releasing oxygen. The fact is that warm alkaline hydrogen peroxide
solution (WAHPS) in local interaction with sputum, mucus, pus, blood and meconium provides
optimal conditions for the metabolism of hydrogen peroxide to oxygen gas under the action
of the enzyme catalase, always present in these tissues. It was established that WAHPS liquefies
these biological masses due to alkaline saponification of lipid and protein-lipid complexes and simultaneously
transforms dense masses into soft oxygen foam due to active enzymatic metabolism
of hydrogen peroxide to oxygen gas, the rapidly appearing bubbles of which are formed by the
type of “cold boiling” and literally explode these masses. The results of the first experiments
showed that inhalation and intrapulmonary injections of WAHPS can significantly optimize the
treatment of suffocation and hypoxemia.

Discussion:

The results showed that catalase, which is found in sputum, mucus, pus, and blood,
may be a target for localized WAHPS because this enzyme provides an intensive metabolism of
hydrogen peroxide to oxygen gas up to the formation of the cold boiling process.

Conclusion:

These data provide a new perspective way for intrapulmonary drugs and new technologies
for the emergency increase of blood oxygenation through the lungs in asphyxia with
thick sputum, mucus, pus, meconium and blood.
Middle Lobe Syndrome in Children: Three Case Reports and a Brief Review
Authors: Spatuzzo Mattia , Mancino Enrica , La Regina Domenico Paolo , Matera Luigi , Virgili Fabrizio , Ialongo Sara , Iovine Elio , Simona Marra , Nenna Raffaella , Midulla Fabio
Published: August 2024

Background:

Middle Lobe Syndrome (MLS) is a pediatric respiratory condition characterized
by the collapse of the middle lobe of the right lung or the lingula of the left lung. Historically
linked with tuberculosis, contemporary cases primarily involve asthma and other causes, like
foreign body aspiration or mucous plug.

Case Presentation:

We have, herein, analyzed the clinical features and management of three cases
of MLS from a single pediatric center. Additionally, we have reviewed 75 articles on pediatric
MLS by using common databases, such as PubMed and Medline.

Discussion:

MLS often poses a diagnostic challenge, presenting with symptoms, like cough,
wheezing, and localized rales. Radiological exams, especially chest X-rays and flexible bronchoscopy,
are needed for confirming the diagnosis, particulary in challenging cases. Both obstructive
and non-obstructive factors contribute to MLS.

Conclusion:

A comprehensive understanding of MLS, its diverse causes, and the significance of
early diagnosis is crucial for effective management. Treatment should target the underlying cause.
Prompt intervention may offer a positive outcome and help prevent complications, like bronchiectasis.
A Promising Paradigm Shift in Cancer Treatment with FGFR Inhibitors
Authors: Mehra Anuradha , Sangwan Rekha
Published: August 2024

FGFR have been demonstrated to perform a crucial role in biological processes but their overexpression
has been perceived as the operator component in the occurrence and progression of different types of
carcinoma. Out of all the interest around cancer, FGFR inhibitors have assembled pace over the past few years.
Therefore, FGFR inhibitors are one of the main fundamental tools to reverse drug resistance, tumor growth, and
angiogenesis. Currently, many FGFR inhibitors are under the development stage or have been developed. Due to
great demand and hotspots, different pharmacophores were approached to access structurally diverse FGFR inhibitors.
Here, we have selected to present several representative examples such as Naphthyl, Pyrimidine, Pyridazine,
Indole, and Quinoline derivatives that illustrate the diversity and advances of FGFR inhibitors in medicinal
chemistry. This review focuses on the SAR study of FGFR inhibitors last five years which will be a great
future scope that influences the medicinal chemist to work towards more achievements in this area.