bluuebunny/crossref_metadata_2025 huggingface dataset:
Abordagem minimamente invasiva para tratamento de fluorose dental com associação de técnicas
Authors: Oliveira Bruna , Santana Carina Silva , Silva Maria Heloiza Oliveira , Oliveira Adriana , da Rocha Daniel Maranha , Nahsan Flavia Pardo Salata
Published: November 2022

A fluorose dentária corresponde a um defeito estrutural no esmalte causado pela exposição prolongada ao flúor durante a formação do germe dentário. As associações de procedimentos minimamente invasivos neste esmalte alterado têm se mostrado um tratamento seguro e eficaz. O objetivo deste trabalho é relatar um caso clínico de manchas de fluorose através da demonstração sequencial de técnicas minimamente invasivas resultando na reabilitação estética de dentes anteriores. O tratamento das manchas fluoróticas assimétricas localizadas na face vestibular das unidades 12, 13, 22 e 23 consistiu na utilização de um gel clareador à base de peróxido de hidrogênio a 35%, sessão única, associado ao peróxido de carbamida a 10%, por duas semanas, seguido da microabrasão com ácido fosfórico e pedra pomes. O resultado demonstrou a atenuação das manchas e sorriso mais estético. Concluiu-se que a associação de técnicas microinvasivas são efetivas quando no diagnóstico acurado.
Tratamento odontológico em pacientes com amelogênese imperfeita – uma revisão integrativa
Authors: Villavicencio Adriana , Franco Ana Paula Gebert de Oliveira , Bettega Patrícia Vida Cassi , de Souza Patrícia Tolentino da Rosa
Published: November 2022

A amelogênese imperfeita é uma anomalia dentária que afeta a estrutura do esmalte dentário, a estética, a função e o aspecto psicológico do indivíduo. Clinicamente compromete a estética do sorriso, apresentando-se como manchas esbranquiçadas, sulcos ou ranhuras, bem como outras alterações na estrutura do esmalte. De acordo com o grau de severidade desta anomalia existem protocolos de tratamentos, como restaurações diretas, indiretas, tais como facetas, coroas e outros métodos de tratamento. Este estudo objetivou avaliar os diferentes tratamentos odontológicos que existem para a amelogênese imperfeita, analisando a longevidade e efetividade de cada tratamento, de acordo com a literatura. Foi consultada a base de dado Pubmed (MEDLINE) utilizando o cruzamento dos descritores: amelogenesis imperfecta AND treatment. Para a busca de trabalhos científicos, os critérios de inclusão foram artigos recentes a partir de 2015, estudos prospectivos com pacientes com amelogênese imperfeita e seus respectivos tratamentos. A literatura recomenda utilização de restaurações e facetas de resina composta para dentes anteriores e restaurações de resina composta e coroas de aço para dentes posteriores de pacientes menores de idade, e de facetas e coroas de cerâmica para pacientes adultos. Concluiu-se que, dentre os tratamentos indicados, a literatura mostra que os materiais cerâmicos apresentaram maior longevidade, porém, o fator idade do paciente deve ser considerado para sua indicação.
Remoção cirúrgica de dente supranumerário impactado em maxila
Authors: Martareli Felipe Cesar , Gonçalves Victor Paes Dias , Teles Samuel Gomes da Silva
Published: November 2022

As técnicas aplicadas às exodontias, sobretudo em dentes inclusos, são diversas e podem confundir o cirurgião dentista sobre qual seria a mais indicada. Os fatores que justificam a escolha por esse procedimento estão relacionados à diversidade de instrumentos e de técnicas e à afinidade e conhecimento do cirurgião dentista, além da associação da técnica com a complexidade de cada caso. Diante disso, o presente trabalho tem como objetivo relatar uma abordagem cirúrgica em um paciente do sexo masculino, de 18 anos de idade, com presença do dente supranumerário incluso com proximidade com os ápices radiculares dos dentes 12 e 13, realizando exodontia do elemento supranumerário e biópsia excisional da lesão. Concluiu-se que, para casos de supranumerário impactado, há a impossibilidade de aproveitamento do elemento, como a ausência de espaço, e da formação de cistos e tumores, optando-se pela extração para facilitar o tratamento ortodôntico e manter a saúde periodontal e a harmonia oclusal dos dentes adjacentes.
COUNSELING GUIDANCE IN ELEMENTARY SCHOOLTHE PANDEMIC: CASE STUDY OF DURING CENDIKIA COUNSELING LITERACY (CCL) AT SD IT CENDEKIA
Authors: Mustikaati Wina , Muharam Agus , Fajrussalam Hisny , Sanny Aprilia , Yani Fitri
Published: November 2022

Literacy is an important thing in the world of education, the importance of literacy requires guidance and counseling. Under normal conditions, the counseling service activities, both educational cinema or CCL, are carried out classically or in groups. However, with the current condition of the Covid pandemic, of course these service activities must continue. To overcome this, the use of CCL is one of the literate counseling techniques to continue to provide counseling services to students. CCL is a Literacy Counseling Scholar is a counseling activity that uses reading media to teach children about literacy. These various literacys will intervene in the behavior of students. This research uses a case study method with low grade objects, in order to analyze and reveal the extent to which CCL can provide life skills, independence and a culture of literacy. It is hoped that by obtaining this study in the future it can create solution ideas as an effort to improve the literacy skills of elementary school studentsKeywords: Guidance Counseling, Counseling Literacy, Cendikia Counseling Literacy
THE TECHNOLOGICAL REVOLUTION AND THE DYNAMICS OF ISLAMIC DA'WAH
Authors: Mubarak Hafiz , Muntaqa A. Wajid , Abidin Ali Mu'ammar Zainal , Sudrajat Didi , Syakhrani Abdul Wahab
Published: November 2022

In Islamic teachings, the effort to carry out Islamic da'wah is an obligation, so that Islam is great because of the vital flow of da'wah. In this technological era, da'wah must be continued by exploiting technology. To complete this discussion, we have conducted a series of literature searches on many online publications, including book journals and websites. In order to obtain valid findings, a series of analyzes involving the tuning coding system and critical evaluation under phenomenology have been carried out. Finally, we believe that the findings include that all Muslims must become a preacher by having Islamic knowledge and skills in using technologically advanced da'wah facilities. Hopefully, this finding will complement the study of da'wah and the technological revolution in the future.
MEMAKNAI PENDIDIKAN SEBAGAI PROYEK MORAL, INTELEKTUAL, DAN SPRITUAL (ANALISIS KRITIS PENAFSIRAN Q.S. AL-MUJADILAH AYAT 11)
Authors: Yusuf Muhammad , Mardan Mardan
Published: November 2022

The education process often produces a dichotomy between moral, intellectual, and spiritual aspects, even though education can make all these aspects simultaneously and in balance. This article is an analytical study of the meaning of verse 11 of Surah al-Mujadilah regarding education that integrates moral, intellectual, and spiritual competencies. Data are tracked and collected from the interpretation of the ulama through books of tafsir, the preachers' explanations, and relevant articles. The analysis was carried out by applying the approach to the sciences of the Koran, the science of interpretation, and educational theory. The understanding of verse 11 surah al-Mujadilah is distorted because of the limited interpreters' competence personally and intellectually and the selection of an inappropriate method of interpretation. The neglect of the moral urgency in education has led to a moral crisis among intellectuals and educated people. The ethical problem is not only happening to ordinary people but also intellectuals. As a result, modern humans who are synonymous with scientific progress are moving towards moral destruction. If morals are broken, it has a destructive impact on the whole.Keywords: Critical Analysis of Education, Intellectual Education, Moral Education
EFEK TERAPI ZIKIR PADA PASIEN STROKE DI RUMAH SAKIT ISLAM METRO
Authors: Khumairo Aisyah , Azizah Nanda
Published: November 2022

Terapi zikir pada pasien stroke di Rumah Sakit Islam Metro dilatar belakangi bahwa sebagian pasien stroke di rumah sakit cenderung sering melamun, mengeluh akan sakit yang dialaminya, lupa akan perintah beribadah kepada Allah dan bahkan ada yang menyalahkan takdir sakit yang mereka derita atau dirasakan sekarang. Hal ini yang menjadikan pasien stroke tidak hanya jasmaninya saja yang perlu diobati namun rohani atau spiritual pasien juga perlu diperbaiki salah satunya dengan pemberian terapi zikir pada pasien stroke. Adapun tujuan dari penelitian adalah untuk mengetahui terapi zikir pada pasien di Rumah Sakit Islam Metro. Penelitian ini menggunakan jenis penelitian lapangan dengan pendekatan metode kualitatif. Sumber data dalam penelitian ini adalah sumber data primer dan sumber data sekunder, yang teknik pengumpulan datanya menggunakan teknik observasi nonpartisipatif, wawancara terstruktur dan dokumentasi. Teknik penjamin keabsahan data menggunakan ketekunan, triangulasi dengan sumber, pemeriksaan sejawat melalui diskusi, uraian rinci dan setelah data diperoleh teknik analisis data kualitatif dengan reduksi, penyajian data, dan penarikan kesimpulan. Hasil penelitian yang diperoleh yaitu, efek yang timbul dengan adanya terapi zikir di Rumah Sakit Islam Metro membuat pasien stroke lebih dekat dengan Allah, lebih tenang, dan pasien stroke lebih optimis untuk mencapai kesembuhan secara optimal.
PENGARUH MEDIA PEMBELAJARAN DAN KOMPETENSI PEDAGOGIK GURU TERHADAP HASIL BELAJAR SISWA DI SMA NEGERI 1 LABUHAN RATU LAMPUNG TIMUR LAMPUNG
Authors: Mardiana Tri , Dacholfany M. Ihsan , Andayani Sutrisni
Published: November 2022

Hasil belajar siswa merupakan tujuan utama dalam kegiatan pembelajaran yang dilakukan oleh guru dalam satuan pendidikan. Hasil belajar siswa merupakan capaian belajar yang diperoleh siswa baik secara kognitif, afektif dan psikomotorik. Capaian atau keberhasilan belajar siswa yang mudah dilihat dalam waktu yang relative singkat adalah capaian belajar secara kognitif  yaitu dengan cara melihat dokumen atau data capaian siswa melalui laporan hasil belajar. Penggunaan media pembelajaran dan kompetensi pedagogik guru memiliki peran penting dalam meningkatkan capaian atau hasil belajar siswa. Penelitian ini merupakan peneliltian dengan pendekatan kuantitatif dengan causal comparative yang merupakan penelitian ex-post facto. Penelitian ini bertujuan untuk mengetahui pengaruh media pembelajaran terhadap hasil belajar siswa, pengaruh kompetensi pedagogik guru  terhadap hasil belajar siswa serta pengaruh media pembelajaran dan kompetensi pedagogik guru terhadap hasil belajar siswa di SMA Negeri 1 Labuhan Ratu Lampung Timur Lampung.  Analsis data penelitian menggunakan analysis regresi linier berganda dengan bantuan aplikasi SPSS. Dari hasil pembahasan diperoleh simpulan terdapat hubungan postif media pembelajaran terhadap hasil belajar siswa, tidak terdapat hubungan positif kompetensi pedagogik guru terhadap hasil belajar siswa serta tidak terdapat hubungan positif media pembelajaran dan kompetensi pedagogik guru terhadap hasil belajar siswa di SMA Negeri 1 Labuhan Ratu Lampung Timur Lampung.
Restorying the life of Martin Luther King: visual and verbal complexity of nonfiction picture book biographies
Authors: Klęczaj-Siara Ewa
Published: November 2022

The article is devoted to the genre of nonfiction picture book biography as a new publishing phenomenon within the area of children's literature. The aim of the article is to analyze the ways of transmitting knowledge by combining visual codes and unconventional verbal narratives in three nonfiction picture book biographies of Martin Luther King, Jr.: Martin's Big Words: The Life of Dr. Martin Luther King, Jr. (2007), I Have a Dream (2012), and Be A King: Martin Luther King, Jr.'s Dream and You (2018). It examines how the selected books invite the readers to participate in the process of meaning making and redefining reality. It also discusses the strategies of counterstorytelling and counter-visuality employed by the creators of the books.
Maravitism in the context of the modernist crisis of the Church. Artur Gruszecki's literary vision
Authors: Trześniowski Dariusz
Published: November 2022

Artur Gruszecki's novel is the only literary testimony of the religious ferment in Poland at the turn of the 19th and 20th centuries, which led to the emergence of a separate christian denomination - mariavitism. The attempt to reform the Catholic Church, undertaken by a group of idealistic priests grouped around Mateczka Kozłowska, met with strong resistance from the Catholic hierarchy, including the apostolic capital of Pope Pius X. Gruszecki shows the bright and dark sides of the mariavite movement to illustrate the genesis of its creation and its failure. The novel itself is a compromise between the assumptions of literary naturalism and the popular novel.
On the need of usage information in dictionary definitions: EFL students of Polish primary schools in focus
Authors: Stachurska Anna
Published: November 2022

Assuming that the information presented in dictionary definitions should indicate that language use depends on the pragmatic situation and the social relationship between speaker and hearer, dictionaries often use special conventions. It is particularly important from the point of view of the language learner that these conventions are not too complicated. Of course, the knowledge of the difference between the semantics of a word and its pragmatic meaning, especially when the dictionary user comes from a different culture, seems to be of prime importance. When consulting dictionaries, the learner of a foreign language needs clear instructions on the formal use of the language, as well as on the use that is not formal, in order to avoid the consequences of a wrong choice.
The awareness of sexting among growing up children and teenagers living in a small town
Authors: Ditrych Karolina
Published: November 2022

An article entitled 'The Awareness of Sexting among Growing up Children and Teenagers Living in a Small Town' describes not new but constantly evolving issue of sharing intimate pictures or videos on the Internet due to the development of technological devices. Selected terminology, like, self gendered content, child grooming, child sexual abuse material - CSAM or child sexual exploitation material - CSEM, is explained. The following part is devoted to introducing the research conducted on 422 respondents from primary schools and high schools located in a small town near Radom and summarising its results. The final part presents unpleasant, for young people, consequences of irresponsible behaviour on the Internet which may lead to serious psychological disorders in their future life.
Métodos de interpretación de las Practicas y sentidos de la Educación Física
Authors: Cachorro Gabriel Armando
Published: November 2022

En este texto abordamos el método sociológico de Weber con sus categorías teóricas de “tipos ideales” y “acciones sociales” como herramientas de trabajo que nos posibilitan procesar datos empíricos extraídos en los trabajos de campo durante el seguimiento de diversas prácticas de la Educación Física. La sociología comprensiva del autor convocado nos provee de insumos teóricos metodológicos para descubrir los sentidos sociales de las diversas formas de conformación de las prácticas de la Educación Física brindando potencia explicativa a sus racionalidades de estas variadas manifestaciones disponibles en la trama de la cultura.
Reseña de la obra de Ramón Burgos (2022), Fútbol y Política. El club Gimnasia y Esgrima y la construcción de una identidad jujeña (1975-2011), (207 p.), San Salvador de Jujuy, Argentina: Tiraxi Ediciones
Authors: Ibarra Mariana
Published: November 2022

Reseña Fútbol y Política. El club Gimnasia y Esgrima y la construcción de una identidad jujeña (1975-2011) de R. Burgos por Mariana Ibarra.
Thermal modeling of a parabolic trough solar collector using finite element method
Authors: Cetina Quiñones Armando Jesus , Bassam Ali , Hernandez Chan Gandhi Samuel , Hernandez Benitez Jose Agustin , Hernández Reyes Ignacio , Lugo Chávez David
Published: November 2022

The purpose of this work is to present the model of a Parabolic Trough Solar Collector (PTC) using the Finite Element Method to predict the thermal behavior of the working fluid along the collector receiver tube. The thermal efficiency is estimated based on the governing equations involved in the heat transfer processes. To validate the model results, a thermal simulation of the fluid was performed using Solidworks software. The maximum error obtained from the comparison of the modeling with the simulation was 7.6% at a flow rate of 1 l/min. According to the results obtained from the statistical errors, the method can effectively predict the fluid temperature at high flow rates. The developed model can be useful as a design tool, in the optimization of the time spent in the simulations generated by the software and in the minimization of the manufacturing costs related to Parabolic Trough Solar Collectors.
Influence Of Moisture Content On Some Physical Properties Of Baobab Seeds (Adansonia Digitata) In Relation To Equipment Development For Postharvest Processing And Handling.
Authors: Ofori Hayford , Dzisi Komla Agbeko , Plange Ato Bart , Addo Ahmad
Published: November 2022

In this study, the effect of moisture content on the physical attributes of baobab seeds was examined, along with the implications for the design of machinery for postharvest handling and processing of the seeds. The seed's volume, sphericity, aspect ratio, axial dimensions, arithmetic, and geometric mean diameters were all determined. Gravimetric properties including porosity, bulk density, and thousand grain mass were measured. Additionally, the seeds' frictional characteristics on different surfaces for handling after harvest were established. The arithmetic and geometric mean diameters were found to be in a range of 8.00 and 9.64 mm and 7.86 and 9.50 mm, respectively, with moisture contents between 5.4 and 20.6% on a dry basis. The seed's sphericity ranged from 78.18 to 80.38 percent. Densities for the bulk and particle ranged from 740.77 to 763.40 kg/m3 and 1155.22 to 1223 -29 kg/m3, respectively. The study revealed that among the four frictional surfaces, plywood surface had the greatest resistance to the flow of the seeds, and the least was registered for the glass surface material. The effect of moisture content on the seed’s physical properties were statistically significant (p≤0.05). Regression equations for future predicting the various physical properties at different moisture contents were developed. The study has produced valuable information that will help with the design of machinery for handling and processing baobab seeds after harvest.
Optimizing Silver Extraction Potential from Waste X-Ray Films Using Acid and Alkaline Leaching Agents
Authors: Adie Gilbert U. , Shoneye Hakeem O. , Iniaghe Paschal O.
Published: November 2022

In this study, the silver extraction potential from waste x-ray films using sodium hydroxide and nitric acid was studied. Sodium hydroxide and nitric acid of different concentrations were used as stripping solutions to determine the optimum leaching concentration. Optimum leaching time and leaching temperature were also investigated by varying the time and temperatures, respectively. The stripped solutions were analysed for silver concentration using Flame Atomic Absorption Spectrophotometer. Results obtained revealed that, for sodium hydroxide stripping, 26.6 mg kg−1 of silver ion was obtained at an optimum leaching concentration, time and temperature of 1.5 M, 900 minutes and 30 °C. For nitric acid stripping, a maximum concentration of 9830.6 mg kg−1 was obtained at optimum concentration, time and temperature of 4 M, 1,440 minutes and 30 °C. The result revealed that the concentration of leaching agent was a significant factor affecting silver recovery, with nitric acid possessing a much higher recovery rate compared to sodium hydroxide.
Nematicidal effect of Raphasatin from Raphanus sativus against Meloidogyne incognita
Authors: Aissani Nadhem , Sebai Hichem
Published: November 2022

The nematicidal activity of radish bulb (Raphanus sativus) methanol (RME) and aqueous extracts (RAE) was tested against the second stage (J2) root knot nematode Meloidogyne incognita model. The EC50 of RME after 3 d of J2 immersion in test solutions was 312 ± 65 μg/ml. However, no activity was noted for RAE (EC50 > 1,000 μg/ml). The chemical composition analysis of the methanol extract carried out by the GC–MS technique showed that 4-methylthio-3-butenyl isothiocyanate (raphasatin) was the most abundant compound at 20%. This pure compound strongly induced J2 paralysis with an EC50 of 1.3 ± 0.2 μg/ml after 24 hr. Comparison with other 11 selected isothiocyanates with structure similarity showed that the double bond at position 3 of the alkyl side chain is important for nematicidal activity, followed by the sulfur group at position 5 and the benzyl group at position 2. In addition, raphasatin showed the highest nematicidal activity with the corresponding lowest antioxidant activity of about 92 ± 18 μg/ml. In conclusion, the results of this investigation reveal that R. sativus and its major compound raphasatin can be integrated into the pest management system.
Host Status of Cover Crops for the Management of Pratylenchus jaehni on Coffee
Authors: Bessi Rosana , Massayuki Inomoto Mário
Published: November 2022

The lesion nematode Pratylenchus jaehni occurs at low frequency in Brazilian coffee orchards but could provoke extensive root damage. Intercropping cover crops is a traditional practice in Brazilian coffee orchards, and the use of non-hosts of P. jaehni as cover crops may be a useful management method. In this work, 10 cover crops were tested concerning reproduction of P. jaehni. Cajanus cajan, Canavalia ensiformis, and Mucuna deeringiana are cover crops commonly used as intercropping in coffee orchards, but they must not be used in orchards infested with P. jaehni, because they are good hosts of this nematode. Brachiaria ruziziensis, Crotalaria juncea, Dolichos lablab, and Pennisetum glaucum were considered poor hosts. Helianthus annuus cv. Catissol and cv. Uruguai and Crotalaria spectabilis proved to be non-hosts to P. jaehni, and therefore, they are the cover crops recommended in coffee orchards infested with this nematode.
Heat–induced changes in soil properties: fires as cause for remobilization of chemical elements
Authors: Fajković Hana , Ivanić Maja , Nemet Ivan , Rončević Sanda , Kampić Štefica , Vazdar Dana Leontić
Published: November 2022

Exposure of soil constituents to elevated temperatures during wildfire can significantly affect their properties and consequently, increase the mobility of the bound contaminants. To estimate the potential of wildfires to influence metal remobilization from the burned soil due to the changes in cation exchange capacity (CEC) after organic matter combustion and mineral alteration and degradation, changes in soil properties after exposure to different temperatures was investigated. This was accomplished through analysis of geochemical, mineralogical and surface physicochemical properties of a soil sample exposed to different temperatures in a laboratory. Heating the soil sample at 200 °C, 500 °C and 850 °C resulted in an increase in pH (from 5.9 to 12.3), decrease in cation exchange capacity (from 47.2 to 7.3 cmol+kg−1) and changes in the specific surface area (observed only at 500 °C), that are associated with structural modifications of clay minerals and ferromagnetic minerals. Extraction analysis showed the increase in the concentration of almost all analysed elements (Al, Cd, Co, Cr, Fe, Mn and Zn) in soil eluates. The observed increase, following high– temperature heating (500 °C and 850 °C), was as much as 15 times higher (e.g., Al), compared to the native soil sample (25 °C). This strongly indicates that wildfire can act as a trigger for remobilization of heavy metals.
Fire-induced changes in soil properties depend on age and type of forests
Authors: Hološ Slavomír , Šurda Peter , Lichner Ľubomír , Zvala Anton , Píš Vladimír
Published: November 2022

Wildfires affect different physical, chemical, and hydraulic soil properties, and the magnitude of their effects varies depending on intrinsic soil properties and wildfire characteristics. The objectives of this study are: to estimate the impact of heating temperature (50–900°C) on the properties of sandy soil (Arenosol) taken in 1) coniferous forests (Scots pine Pinus sylvestris) of different ages (30 and 100 years); and 2) coniferous (Scots pine Pinus sylvestris) and deciduous (alder Alnus glutinosa) forests of the same age (30 years). The forests are located in the central part of the Borská nížina lowland (western Slovakia), and the properties treated were soil organic carbon content (SOC), pH, and soil water repellency (measured in terms of water drop penetration time, WDPT). It was found that the impact of heating temperature on the properties of sandy soil is great and depends on both the age and type of forest. The SOC value decreased unevenly with temperature in all three soils, and it was higher in the 30-year-old deciduous forest soil than in the 30-year-old coniferous forest soil. The value of pH increased monotonously with temperature from 200 °C, and it was higher in 30-year-old coniferous forest soil than in the 100-year-old coniferous forest soil. SOC and WDPT in the 100-year-old coniferous forest soil were higher than SOC and WDPT in the 30-year-old coniferous forest soil. Results obtained (decrease in SOC, disappearance of SWR after heating to 400 °C, and increase in pH from heating temperature 200 °C) bring important information for post-fire vegetation restoration and post-fire management of Central European forests established on sandy soil.
A Modelling System for Evaluating Options for Building and Using a Fleet of Battery Electric Trucks
Authors: Yatskiv (Jackiva) Irina , Tolujevs Jurijs , Petrovs Vladimirs , Vesjolijs Aleksejs
Published: November 2022

Many shipping companies tackle the challenge of potentially replacing conventional trucks with electric ones in economically developed countries. The aim of this work is to describe the principle of scaling models for analysing the operation of a fleet of vehicles, when the decision to use a particular type of model is made considering the accuracy and completeness of the initial data, as well as the goals of modelling. At the end of the report, information is provided on the TraPodSim simulation system developed by the authors, which is based on a multi-agent simulation model created using AnyLogic software.

The paper considers modelling methods aimed at assessing the physical indicators of the transportation process. Various aspects of using three types of mathematical models are discussed: a) analytical deterministic models, b) analytical models using the Monte Carlo method and c) simulation models.
Embracing Implementation Science in Nursing and Midwifery to translate evidence-based interventions into policies and clinical practice
Authors: Zungu Lindiwe , Setswe Geoffrey
Published: November 2022

Evidence-based interventions (EBIs) are the subject of dissemination and implementation efforts in nursing and midwifery. Nursing and midwifery research generates mountains of EBIs with proven efficacy and effectiveness. These include interventions such as the diabetes prevention programme, practices such as cervical cancer screening, and workplace policies such as Covid-19 vaccination. However, evidence is not always used in practice, and there are many examples of problematic implementation of research into practice. Implementation science, defined as “the scientific study of methods to promote the systematic uptake of research findings and other evidence-based practice into routine practice … to improve the quality and effectiveness of health services” (Eccles and Mittman 2006), is increasingly being used to implement evidence-based nursing interventions in real-life settings.
Gestação e puerpério: vivências de mulheres frente a pandemia da COVID-19
Authors: Pereira Camila Carvalho , Oliveira Virgínia Junqueira , Viegas Selma Maria da Fonseca , Oliveira Vânia Aparecida da Costa , Pinto Jeizziani Aparecida Ferreira
Published: November 2022

Objetivo: Compreender a perspectiva das mulheres do processo gravídico puerperal e da amamentação no contexto da pandemia da COVID-19. Métodos: Trata-se de uma pesquisa qualitativa, do tipo interpretativa, cuja abordagem metodológica utilizada foi a Análise de Conteúdo Temática. O cenário compreende uma unidade de Estratégia Saúde da Família de um município mineiro, sendo realizado com 17 mulheres que foram atendidas na determinada unidade durante o período de março de 2020 até agosto de 2021 e que estivesse passando pelo período gestacional e posteriormente, no puerpério. Resultados: O período pandêmico desencadeou sensações de solidão na gestante, devido a necessidade de manter um isolamento e medo de contrair o vírus, transmitindo para o bebê e acabar causando alguma complicação na gestação. Conclusão: A pandemia influenciou no cotidiano e nos hábitos de vida das gestantes, ao desencadear medos e angústia nas mulheres que vivenciaram o processo gravídico/puerperal, ocasionando alteração dos padrões emocionais bem como contribuiu para o surgimento de ansiedade e sentimentos antes não vivenciados. Deve ser pertinente aos resultados apresentados.
As consequências do uso prolongado de corticosteroides inalatórios em crianças com asma
Authors: Gomes Leonardo Sousa , Oliveira Paula Mendes Ribeiro e , Reis Carlena Góes , Cardoso Tiago Carneiro , Xavier Gabriel Meira , Araújo Vítor Andrade de , Gomes Ana Carolina Sousa , Mota Heitor de Sousa
Published: November 2022

Objetivo: Compreender as consequências do uso prolongado de Corticosteroides Inalatórios (CI) em crianças com asma. Revisão bibliográfica: Quando a asma não é bem controlada com altas doses de CI é provável que ocorram efeitos colaterais sistêmicos. Ademais, tais efeitos colaterais podem ocorrer devido à deposição local de corticoide na orofaringe e laringe. Dentre os efeitos da deposição local, tem-se a disfonia. Outra preocupação é sobre a influência dos CI no sistema esquelético, pois podem causar desaceleração do crescimento e aumento do risco de osteoporose em crianças. Os glicocorticóides também inibem a absorção intestinal de cálcio, aumentam a excreção urinária de cálcio e interrompem a formação óssea, o que pode afetar negativamente a crescimento. Não obstante, durante a inalação, parte da dose pode ser absorvida pelo trato gastrointestinal, entrando posteriormente na circulação causando efeitos colaterais sistêmicos. Considerações finais: Para crianças com asma persistente, os CI são medicamentos altamente eficazes que, quando prescritos e monitorados criteriosamente, têm benefícios que excedem claramente os riscos potenciais.
Histórico da Vacinação no Brasil e o atual cenário em decorrência da pandemia da COVID-19
Authors: Dande Grazieli Miranda Siqueira , Silva Júnior Sinézio Inácio da , Martinez Maria Regina
Published: November 2022

Objetivo: Levantar os aspectos que marcaram a história das vacinas em nosso país, como também questões referentes à cobertura vacinal. Revisão Bibliográfica: Inicialmente foram apresentados os aspectos históricos que envolvem o surgimento das vacinas no mundo e no Brasil, focando na técnica de variolação, técnica esta que introduziu o conceito de vacinas no mundo. As descobertas e fatos considerados como grandes marcos da história da vacina foram explanados, evidenciando a importância do Programa Nacional de Vacinação na contenção da morbimortalidade de doenças imunopreveníveis. Desta forma, evidenciou-se que a cobertura vacinal preconizada pelo programa influencia diretamente no número de casos de doenças passíveis de vacinação, sendo que, quanto maior a cobertura vacinal, menor o risco para a população exposta. Em seguida foi abordado o atual contexto da pandemia da COVID-19, com foco nos aspectos relacionados à vacinação, e, ao final, foi realizada uma reflexão sobre os valores atuais da cobertura vacinal em nosso país. Considerações Finais: Ocorreram importantes avanços em relação a vacinação, no entanto, o alcance das metas propostas de cobertura vacinal continua sendo um desafio.
Uso terapêutico da toxina botulínica para o tratamento da enxaqueca crônica
Authors: Freitas Damara Zayane Barros , Nogueira Raquel Bezerra de Sá de Sousa , Sousa Milena Nunes Alves de , Nogueira Tiago Bezerra de Sá de Sousa
Published: November 2022

Objetivo: Identificar o benefício do uso da toxina botulínica na diminuição dos sintomas da enxaqueca. Métodos: Trata-se de uma revisão integrativa de literatura, de caráter descritivo e qualitativo, a partir de estudos minuciosos encontrados nas bases de dados U.S. National Library of Medicine and the National Institute of Health (PUBMED), Biblioteca Virtual em Saúde (BVS), Scientific Eletronic Library Online (SCIELO) e Google Acadêmico, após aplicação das palavras de pesquisa “toxina botulinica and enxaqueca” com os filtros: espaço temporal de 2017 a 2022, artigos publicados em inglês e português. Resultados: De acordo com o estudo, observou-se que existem vários fatores que contribuem para a toxina botulínica agir na diminuição da enxaqueca nos pacientes, tendo como mais frequente a aplicação no couro cabeludo (43,75%), seguida da administração em vários ciclos (25%) e, por fim, o uso nas vias subcutânea e intramuscular associado aos números de aplicação de analgésicos representaram 18,75%. Esses resultados foram a base de um tratamento qualificado após diagnóstico correto, na tentativa de minimizar as consequências da doença. Considerações finais: Para a enxaqueca crônica, que impacta a vida dos pacientes, foi demonstrada a eficácia da toxina botulínica na terapêutica dessa doença a partir de resultados satisfatórios e seguros quanto à utilização.
A Case of Pityriasis Rosea Following Monkeypox Vaccination
Authors: Beiter Kaylin , Swigert Anna , Elewski Boni
Published: November 2022

Introduction: Pityriasis rosea (PR) is a well-known but uncommon, benign papulosquamous skin condition that often occurs after viral infections or vaccinations. The most commonly implicated vaccine is smallpox. Monkeypox (MPX), a related virus to smallpox within the orthopox family, has recently grown in public health concern. We present here a case of PR following MPX vaccination in an African-American man.
Case Report: A 32-year old African-American man presented for evaluation of a one-month history of rash that first appeared as an isolated itching spot on his right mid-back, followed by papular eruptions on his trunk with extremity sparing. He denied recent illnesses, medication use including NSAIDs, or history of similar rash. He did report receiving his first MPX dose about one week prior to rash onset. Pityriasis rosea was diagnosed based on clinical presentation and suspected secondary to the patient’s MPX vaccine course.
Conclusion: There are currently two available vaccines for MPX protection in the United States, both of which are vaccinia-based and developmentally related to the smallpox vaccine. Given the known association of smallpox and PR, PR reactions following MPX vaccination may occur.
Numerous Spider Angiomas as the Presenting Sign of Acute Graft Versus Host Disease
Authors: Lanyi Shira , Wills Abigail , Schenck Olivia
Published: November 2022

Graft versus host disease (GVHD) is a highly morbid immunologic reaction and complication commonly seen in response to allogenic hematopoietic stem cell transplant. The underlying pathophysiology of this reaction is due to donor T-lymphocyte migration and activation of the host’s innate immune system. Quality of life is significantly impacted in these patients, particularly in those with chronic GVHD. GVHD may impact multiple organ systems, however, cutaneous involvement is the most common finding and is often the initial presenting sign. The clinical manifestations of cutaneous GVHD are highly variable, with many morphologies mimicking another skin condition.  We present a rare case of a 51-year-old male, who presented with multiple spider hemangiomas over the chest and back and a history of allogenic stem cell transplant and no history of liver disease, who was diagnosed with acute GVHD.
Flagellate Dermatitis following Shiitake Mushroom Consumption
Authors: Mai Kevin , Adams Derrick , Li Jung
Published: November 2022

The diagnosis of Shiitake flagellate dermatitis is often overlooked due to the rarity of the condition and the commonality of shiitake mushroom consumption. As the popularity of shiitake mushroom rises and is further incorporated into Western diets, there will be a greater chance of coming across shiitake flagellate dermatitis. In this report, we present a middle-aged female patient who developed shiitake flagellate dermatitis following the consumption of shiitake mushrooms. The physical examination showed characteristic erythematous linear papules in a flagellate like pattern across her neck, abdomen, and thighs. Biopsies demonstrated perivascular, lymphocytic infiltrates with scarce eosinophils. Awareness and familiarity to this condition may aid in addressing patient’s worries and preventing unnecessary procedures or treatments which may exacerbate symptoms.
The Integrated 31-Gene Expression Profile (i31-GEP) Test for Cutaneous Melanoma Outperforms a Clinicopathologic-only Nomogram at Identifying Patients who can Forego Sentinel Lymph Node Biopsy
Authors: Zakria Danny , Brownstone Nicholas , Rigel Darrell
Published: November 2022

Introduction: National guidelines for cutaneous melanoma suggest avoiding sentinel lymph node biopsy (SLNB) if the risk of SLN positivity is <5% (T1a with no high-risk features), considering SLNB if the risk is 5-10% (T1a with additional high-risk features (T1aHR) and T1b), and offering SLNB if the risk is >10% (T2-T4). Because most patients (88%) who undergo an SLNB have a negative result, novel tools to identify patients who can safely forgo SLNB are critical. The integrated 31-gene expression profile (i31-GEP for SLNB) test for cutaneous melanoma combines tumor molecular biology with clinicopathologic features to provide a precise risk of SLN positivity. The Melanoma Institute of Australia (MIA) developed a nomogram that uses only clinicopathologic features to predict SLN positivity.

Methods: We compared the i31-GEP for SLNB to the MIA nomogram in patients with T1-T2 tumors with complete data (n=582). The precision of each tool to identify patients with <5% SLN positivity risk was analyzed using 95% confidence intervals. To be considered low risk, the predicted risk must be <5% and the upper 95% confidence interval must be ≤10%, and to be considered high-risk, the predicted risk must be >10% and the lower 95% CI ≥5%.

Results: The i31-GEP for SLNB identified 28.5% (166/582) of patients as having a <5% risk of SLN positivity while also having an upper 95% CI ≤10% compared with 0.9% (5/582, p<0.001) using the MIA nomogram. In patients with a pre-test likelihood of SLN positivity of 5-10% (T1aHR-T1b), the i31-GEP reclassified risk in 60.2% (171/284) of patients as being <5% or >10%  compared to 13.7% (39/284, p<0.001) using the MIA nomogram. In patients with a known SLN status (n=466), the i31-GEP for SLNB identified 22.1% (103/466) of patients as having <5% risk, with a 3.9% (4/103) SLN positivity rate compared to 0.6% (3/466, p<0.001) identified by the MIA as having a <5% risk with a 33.3% (1/3) SLN positivity rate.

Conclusions: The i31-GEP test outperformed the MIA nomogram in identifying patients who could safely forego SLNB. Integrating the 31-GEP molecular risk stratification tool with clinicopathologic features provides precise SLN positivity risk to better guide patient management in patients with T1-T2 tumors, for whom SLNB guidance could be most impactful.
Support Group Utilization and Perspectives Among Hidradenitis Suppurativa Patients
Authors: De Devea , Shih Terri , Atluri Swetha , Fixsen Denise , Brooks Brindley , Hsiao Jennifer , Shi Vivian
Published: November 2022

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis associated with significant psychosocial burden. HS patients are more likely to experience mental health comorbidities such as depression and anxiety. They may also experience isolation due to fear of stigmatization as HS lesions are often associated with pain, scarring, and odor.  This study investigates the perspectives of HS patients on HS support groups and the usage of this resource among this population.
Methods: An anonymous Redcap survey was utilized via online social media HS support groups between 10/2021-1/2022 to collect demographic, usage, and perspective data. Comparative statistics were conducted and p-value of <0.05 was considered significant.
Results: Of the 166 respondents, 78% respondents were part of an HS support group however, only 12% of respondents were recommended to join by their main HS healthcare provider and most (68%) learned about support groups through their own internet searches. Most respondents were daily (42%) and weekly (38%) support group users. Virtual meetings were preferred by the majority compared to in person meetings (50% vs 13%). The top reasons respondents reported attending support groups were to better understand HS, increasing their knowledge of HS resources, and access to treatment/care tips. Respondents without dermatologists as their main HCP and skin of color (SOC) respondents were more likely to report that support groups improved their care of HS (4.29 vs 3.90, p=0.031).
Conclusion: Our findings highlight the preferential format of virtual support groups and that support groups may be an underutilized resource by healthcare providers for their patients. Support groups may help to narrow gaps in education when patients are unable to access or have delays in obtaining dermatological care, especially in SOC patients who have historically experienced higher rates of healthcare disparities.
Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, versus placebo and apremilast in moderate to severe plaque psoriasis: analysis of body surface area involvement in the phase 3 POETYK PSO-1 and PSO-2 trials
Authors: Lambert Jo , Paul Carle , Gottlieb Alice , Poulin Yves
Published: November 2022

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Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in moderate to severe plaque psoriasis: 52-week efficacy by prior treatment in the phase 3 POETYK PSO-1 trial
Authors: Bagel Jerry , Armstrong April , Warren Richard , Papp Kim , Thaçi Diamant , Menter Alan , Cather Jennifer , Augustin Matthias , Hippeli Lauren , Daamen Carolin , Griffiths Christopher
Published: November 2022

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Exposure–Response Analysis Demonstrates Response to Tapinarof is Driven by Local Effects at Sites of Application
Authors: Del Rosso James , Guenthner Scott , Hong Chih-ho , Jett John E , Brown Philip M , Rubenstein David S , Piscitelli Stephen C , Piscitelli Stephen C
Published: November 2022

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Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Pooled Efficacy from Three Phase 3 Trials
Authors: Stein Gold Linda , Lebwohl Mark , Bissonnette Robert , Strober Bruce , Tallman Anna M , Brown Philip M , Piscitelli Stephen C , Rubenstein David S
Published: November 2022

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Treat-to-Target Outcomes and Measures of Treatment Success in Three Phase 3 Trials of Tapinarof Cream 1% Once Daily for Mild to Severe Plaque Psoriasis
Authors: Armstrong April W , Bissonnette Robert , Brown Philip M , Tallman Anna M , Papp Kim A
Published: November 2022

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Enhanced Skin Deposition of Betamethasone Dipropionate into the Skin of Human Volunteers from Calcipotriene/Betamethasone Dipropionate Cream Compared to Topical Suspension
Authors: Draelos Zoe D , Draelos Matthew M , Praestegaard Morten
Published: November 2022

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Calcipotriene (CAL) and Betamethasone Dipropionate (BDP) Cream Demonstrates High Efficacy and Convenience in Skin of Color Patients with Plaque Psoriasis
Authors: Callender Valerie , Taylor Susan , Cook-Bolden Fran
Published: November 2022

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Patient Perspectives on the Prevalence and Burden of Intertriginous Psoriasis: Results From a National Survey of Adults With Psoriasis in the United States
Authors: Greiling Teri , Young Melodie , Higham Robert C , Armstrong April W
Published: November 2022

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Indirect comparison of the short-, mid-, and long-term efficacy of treatments for moderate to severe plaque psoriasis: a systematic review and network meta-analysis
Authors: Armstrong April W , Warren Richard B , Zhong Yichen , Zhuo Joe , Cichewicz Allie , Kadambi Ananth , Junqueira Daniel R , Westley Tracy , Kisa Renata , Daamen Carolin , Augustin Matthias
Published: November 2022

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Bimekizumab efficacy and safety through two years in patients with moderate psoriasis: Analysis of pooled data from five phase 3/3b clinical trials
Authors: Blauvelt Andrew , Stein Gold Linda , Gooderham Melinda , Strober Bruce , Pinter Andreas , Carrascosa Jose-Manuel , Gisondi Paolo , Bleier Jonathan , Madden Cynthia , Deherder Delphine , Gomez Natalie Nunez , Warren Richard B
Published: November 2022

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Bimekizumab speed of response in patients with moderate to severe plaque psoriasis: Results from four phase 3/3b trials (BE VIVID, BE READY, BE SURE, and BE RADIANT)
Authors: Blauvelt A , Duffin KC , Magnolo N , Weisman J , Ståhle M , Wilsmann-Theis D , Wang M , Wixted K , Szilagyi B , Puig L
Published: November 2022

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Bimekizumab infection rates in patients with moderate to severe plaque psoriasis: Analysis of pooled data from 2 years of treatment in phase 3 and 3b clinical trials
Authors: Armstrong A , Langley RG , Gordon KB , Warren RB , Thaçi D , Stein Gold L , Peterson L , Madden C , Nunez Gomez N , De Cuyper D , Costanzo A
Published: November 2022

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Bimekizumab in patients with moderate to severe plaque psoriasis by bodyweight: Pooled results from phase 3 trials
Authors: Pinter Andreas , Strober Bruce , Rosmarin David , Gisondi Paolo , Vanvoorden Veerle , Peterson Luke , Madden Cynthia , De Cuyper Dirk , Warren Richard B
Published: November 2022

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Colloidal synthesis of photoactive p-type spinel copper gallate nanocrystals
Authors: Kendall Owen , Melendez-Correa Lesly , Ren Jiawen , Ratnayake Samantha , Murdoch Billy , Mayes Edwin , van Embden Joel , Gomez Daniel , Calzolari Arrigo , Della Gaspera Enrico
Published: November 2022

Herein we report the synthesis and characterization of spinel copper gallate (CuGa2O4) nanocrystals (NCs) with an average size of 3.7 nm via a heat-up colloidal reaction. CuGa2O4 NCs have a band gap of ~2.5 eV and a strong p-type character, in agreement with ab initio simulations. These NCs are demonstrated to be photoactive, generating a reproducible photocurrent under blue light irradiation when deposited as a thin film. The ability to adjust the Cu:Ga ratio within the NCs, and its effect on the optical and electronic properties of the NCs was also demonstrated.
Modeling Light-Induced Chromophore Hydration in the Reversibly Photoswitchable Fluorescent Protein Dreiklang
Authors: Grigorenko Bella , Polyakov Igor , Nemukhin Alexander
Published: November 2022

We report the results of a computational study of the mechanism of the light-induced chemical reaction of chromophore hydration in the fluorescent protein Dreiklang responsible for its switching from the fluorescent ON-state to the dark OFF-state. We explore the relief of the potential energy surface from the excited-state level of the charge-transfer character in the ON-state to locate conical intersection points with the ground state energy surface. Simulations of further evolution of model systems allow us to characterize the ground-state reaction intermediate tentatively suggested in the femtosecond studies of the light-induced dynamics in Dreiklang and finally to arrive to the reaction product. The obtained results clarify the details of the photoswitching mechanism in Dreiklang, which is due to the chemical modification of the fluorescent protein chromophore.