bluuebunny/crossref_metadata_2025 huggingface dataset:
A Pediatric Case of Reninoma Presenting with Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Secretion
Authors: Sekhon Sarpreet S. , Taha Khalid , Kim Laura H. , Humphreys Robert , Patel Trisha J. , Andrews Alicia R. , Lee Anna F. , Abdulhussein Fatema S.
Published: December 2023

Introduction: A reninoma (juxtaglomerular cell tumor) is a rare cause of secondary hypertension that can present with headaches alongside the triad of severe hypertension, hypokalemia, and metabolic alkalosis. Case Presentation: We describe a case of a 15-year-old previously healthy girl who presented with headaches and hypertensive urgency who had severe hypokalemia, moderate hyponatremia, and elevated aldosterone and renin levels. Abdominal ultrasound and MRI with contrast revealed a unilateral mass localized to the right kidney. Despite treatment of her hypertension, she had persistent hyponatremia with clinical euvolemia which was consistent with the paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). She underwent radical nephrectomy which normalized her blood pressure and aldosterone and renin values. The pathology findings were consistent with a reninoma with a mitotic rate of 1–2 mitoses per 10 high power fields. Discussion: Hypertension in the pediatric age group requires workup to rule out secondary causes. The classic triad of hypertension, hypokalemia, and metabolic alkalosis warrants assessment for aldosterone-mediated hypertension which can be a result of a renin-producing tumor. Curative approach requires surgical resection of the tumor. Reninomas may rarely manifest with a paraneoplastic phenomenon including SIADH, as seen in our case. Although reninomas are benign tumors, there are also a few reports of malignant transformation and metastases. Features uncommon in reninomas such as mitotic activity warrant long-term surveillance.
False-Positive Liquid Biopsy Assays Secondary to Overlapping Aberrant Methylation from Non-Cancer Disease States
Authors: Lutfi Areeb , Afghan Maaz Khan , Swed Brandon , Kasi Pashtoon Murtaza
Published: December 2023

Introduction: Liquid biopsies are increasingly being adopted in the care of patients with cancer. Not only in patients with metastatic disease but the utility is also being recognized in earlier phases of the journey of a patient with cancer. More recently, methylated platforms are offering another lens of looking at the same question more so in minimal residual disease (MRD) and early detection settings. While false positives secondary to clonal hematopoiesis of indeterminate potential (CHIP) are recognized as one entity to consider when interpreting these assays, and advanced CHIP filtering bioinformatics platforms can prevent this, false positives secondary to aberrant methylation are not described. Case Presentation: Herein, we report a case of a patient with hepatitis C-related viremia and a very high viral load that had a false-positive plasma-only colorectal MRD assay. The colorectal MRD assay spontaneously cleared on hepatitis C virus therapy which led to clearance of the virus. Conclusion: As these assays are increasingly applied in real-world settings, it would be of value to consider non-cancer chronic disease states that may lead to aberrant methylation that could lead to a false-positive assay.
White Matter Hyperintensities on Post-Stroke Balance and Gait Recovery: A Prospective Cohort Study Protocol
Authors: Lei Hanhan , Huang Huayao , Yuan Qilin , Fang Shuangfang , Wu Xiaomin , Lin Huiyin , Chen Qingfa , Zhang Yixian , Wei Jin , Chen Guangliang , Li Hongxiang , Liu Nan , Du Houwei
Published: December 2023

Introduction: White matter hyperintensities (WMH) are commonly associated with balance and gait disturbances. Little is known whether WMH may affect post-stroke balance and gait recovery. We aim to investigate the association of post-stroke balance and gait recovery with imaging marker of WMH on magnetic resonance imaging (MRI). Methods: This prospective cohort study will enroll consecutive patients with first-ever ischemic hemisphere stroke, between September 2023 and December 2024. Clinical data will be collected on day 30 ± 3 and at 3 months after stroke onset. WMH on FLAIR are graded according to the modified Fazekas scale. Resting-state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI) will be acquired to evaluate functional and structural connectivity. The primary endpoint is balance recovery, defined as a Postural Assessment Scale for Stroke score of 32 or higher at 3 months. The secondary endpoint is gait recovery, assessed using the modified Fugl-Meyer Gait Assessment at 3 months. We will investigate the association of post-stroke balance and gait recovery with WMH severity as well as WMH-related functional and structural connectivity. Conclusion: The study may contribute to clarify the effect of WMH on post-stroke balance and gait disorder recovery.
A Systematic Bibliometric Analysis of High-Impact Articles in Critical Care Nephrology
Authors: Platnich Jaye , Kung Janice Y. , Romanovsky Adam S. , Ostermann Marlies , Wald Ron , Pannu Neesh , Bagshaw Sean M.
Published: December 2023

Introduction: Critical care nephrology is a subspecialty that merges critical care and nephrology in response to shared pathobiology, clinical care, and technological innovations. To date, there has been no description of the highest impact articles. Accordingly, we systematically identified high impact articles in critical care nephrology. Methods: This was a bibliometric analysis. The search was developed by a research librarian. Web of Science was searched for articles published between January 1, 2000 and December 31, 2020. Articles required a minimum of 30 citations, publication in English language, and reporting of primary (or secondary) original data. Articles were screened by two reviewers for eligibility and further adjudicated by three experts. The “Top 100” articles were hierarchically ranked by adjudication, citations in the 2 years following publication and journal impact factor (IF). For each article, we extracted detailed bibliometric data. Risk of bias was assessed for randomized trials by the Cochrane Risk of Bias tool. Analyses were descriptive. Results: The search yielded 2,805 articles. Following initial screening, 307 articles were selected for full review and adjudication. The Top 100 articles were published across 20 journals (median [IQR] IF 10.6 [8.9–56.3]), 38% were published in the 5 years ending in 2020 and 62% were open access. The agreement between adjudicators was excellent (intraclass correlation, 0.96; 95% CI, 0.84–0.99). Of the Top 100, 44% were randomized trials, 35% were observational, 14% were systematic reviews, 6% were nonrandomized interventional studies and one article was a consensus document. The risk of bias among randomized trials was low. Common subgroup themes were RRT (42%), AKI (30%), fluids/resuscitation (14%), pediatrics (10%), interventions (8%), and perioperative care (6%). The citations for the Top 100 articles were 175 (95–393) and 9 were cited >1,000 times. Conclusion: Critical care nephrology has matured as an important subspecialty of critical care and nephrology. These high impact papers have focused largely on original studies, mostly clinical trials, within a few core themes. This list can be leveraged for curricula development, to stimulate research, and for quality assurance.
Modeling the Role of Contour Integration in Visual Inference
Authors: Khan Salman , Wong Alexander , Tripp Bryan
Published: December 2023

Under difficult viewing conditions, the brain’s visual system uses a variety of recurrent modulatory mechanisms to augment feedforward processing. One resulting phenomenon is contour integration, which occurs in the primary visual (V1) cortex and strengthens neural responses to edges if they belong to a larger smooth contour. Computational models have contributed to an understanding of the circuit mechanisms of contour integration, but less is known about its role in visual perception. To address this gap, we embedded a biologically grounded model of contour integration in a task-driven artificial neural network and trained it using a gradient-descent variant. We used this model to explore how brain-like contour integration may be optimized for high-level visual objectives as well as its potential roles in perception. When the model was trained to detect contours in a background of random edges, a task commonly used to examine contour integration in the brain, it closely mirrored the brain in terms of behavior, neural responses, and lateral connection patterns. When trained on natural images, the model enhanced weaker contours and distinguished whether two points lay on the same versus different contours. The model learned robust features that generalized well to out-of-training-distribution stimuli. Surprisingly, and in contrast with the synthetic task, a parameter-matched control network without recurrence performed the same as or better than the model on the natural-image tasks. Thus, a contour integration mechanism is not essential to perform these more naturalistic contour-related tasks. Finally, the best performance in all tasks was achieved by a modified contour integration model that did not distinguish between excitatory and inhibitory neurons.
The troglomorphic pseudoscorpions of the genus Neobisium from Corsica, Sardinia and mainland Italy, with description of new species (Pseudoscorpiones: Neobisiidae)
Authors: GARDINI GIULIO
Published: December 2023

A taxonomic revision and a key to the pseudoscorpion species of Neobisium Chamberlin, 1930―so far attributed to the subgenus Ommatoblothrus Beier, 1956―from Corsica, Sardinia and mainland Italy are provided. The taxonomic status of the subgenera of Neobisium Chamberlin, 1930 is evaluated and the following new synonymies are proposed: Ommatoblothrus Beier, 1956 is a junior subjective synonym of Neobisium Chamberlin, 1930 (n. syn.), Heoblothrus Browning, 1965 is a junior subjective synonym of Neobisium Chamberlin, 1930 (n. syn.), Pennobisium Ćurčić 1988 is a junior subjective synonym of Neobisium Chamberlin, 1930 (n. syn.). The following new species are described: Neobisium (Neobisium) corsicum n. sp. (♀, loc. typ.: Corsica, Corte, Grotte de Valletto), Neobisium (N.) leolatellai n. sp. (♂♀, loc. typ.: Latium, Bassiano, Grotta della Cava 384 La/LT), Neobisium (N.) magrinii n. sp. (♂♀, loc. typ.: Latium, Coreno Ausonio, Grotta l’Arnale 871 La/FR), Neobisium (N.) petruzzielloi n. sp. (♂♀, loc. typ.: Campania, Avella, Grotta degli Sportiglioni 184 Cp/AV) and Neobisium (N.) vignai n. sp. (♂♀, loc. typ.: Latium, Amaseno, Grotta degli Ulivi 474 La/FR). The specimens of five populations from as many caves of the Lepini Mountains are provisionally attributed to Neobisium (N.) sp. aff. patrizii Beier, 1953, and the following new synonymy is proposed: Neobisium patrizii romanum Mahnert, 1980 is a junior subjective synonym of Neobisium patrizii patrizii Beier, 1953 (n. syn.).
Transnasal Humidified Rapid Insufflation Ventilatory Exchange in Endoscopic Esophageal Surgery
Authors: Yang Zao M. , Loh Tuan-Hsing , Ross Justin , Dalal Kajal , Meiler Steffen E. , Postma Gregory N.
Published: December 2023

Objectives:

Transnasal humidified rapid insufflation ventilatory exchange (THRIVE) describes apneic oxygenation using humidified high flow nasal-cannula oxygen. Although it has been described as a sole mode of oxygenation in endoscopic laryngotracheal surgery, its use in endoscopic esophageal surgery under general anesthesia with neuromuscular paralysis has not previously been described. The objective of this study is to assess the safety and efficacy of THRIVE in esophagology.

Methods:

We conducted a retrospective review of adult patients undergoing esophageal procedures under general anesthesia who were oxygenated using THRIVE at two academic institutions. Demographic, clinical, and anesthesiologic data were collected and analyzed.

Results:

14 cases performed from March 2021 to March 2022 met inclusion criteria. 13/14 (92.9%) of patients were able to maintain oxygenation throughout the entirety of their procedure. The mean apneic time was 17.9 minutes with a maximum of 32 minutes. One patient required “rescue” intubation due to failure to maintain oxygenation. Excluding the sole THRIVE failure, the median SpO2 at the conclusion of surgery was 99% (range 94-100%). A linear regression model yielded an increase in EtCO2 of 0.95 mmHg/min or 0.127 kPa/min. SpO2 was negatively associated with both tobacco pack-year smoking history (R2 = 0.343, P = .014) and BMI (R2 = 0.238, P = .038).

Conclusion:

THRIVE is a feasible, safe, and efficacious means of apneic oxygenation for patients undergoing esophageal endoscopic surgery under general anesthesia with neuromuscular paralysis, which may be particularly beneficial in patients with airway stenosis, as post-intubation changes can have severe clinical implications for this patient population. Obese patients and tobacco smokers may be at increased risk of oxygen desaturation when using THRIVE.
Influence of hydrothermal conditions on the mechanical properties of hybrid composite pipes
Authors: Kepir Yusuf , Kara Memduh
Published: December 2023

Composite materials are becoming widespread in many sectors today, especially in the defence and space industry. Composite materials can be exposed to significant temperature changes and various environmental conditions depending on their usage areas. Therefore, composite materials with high resistance to high temperatures and harsh environmental conditions are being studied today. In this study, four types of 6-layer composite pipes with glass/glass/glass, basalt/basalt/basalt, glass/basalt/glass and basalt/glass/basalt stacking sequences were fabricated with filament wound method. In order to simulate the behavior of composite materials under environmental conditions, specimens were subjected to hydrothermal aging in pure water at 70°C for three different periods of 500, 1000 and 1500 hours. During the aging process, the mass changes of the pipes were measured regularly, and the water absorption behavior was determined with reference to ASTM D5229 standard. Hardness tests were carried out with Rockwell hardness tester based on ASTM D785 standard. As a result of the study, it was determined that the mechanical performance of hybrid specimens was higher than that of non-hybrid specimens. It was observed that the hydrothermal aging process caused a loss of mechanical strength in all specimens. It was concluded that the hybrid composite specimen with basalt/glass/basalt stacking order had the highest resistance to hydrothermal aging.
Pain management in zebrafish
Authors: Sneddon Lynne U , Schroeder Paul , Roque Ana , Finger-Baier Karin , Fleming Angeleen , Tinman Simon , Collet Bertrand
Published: December 2023

Empirical evidence suggests fishes meet the criteria for experiencing pain beyond a reasonable doubt and zebrafish are being increasingly used in studies of pain and nociception. Zebrafish are adopted across a wide range of experimental fields and their use is growing particularly in biomedical studies. Many laboratory procedures in zebrafish involve tissue damage and this may give rise to pain. Therefore, this FELASA Working Group reviewed the evidence for pain in zebrafish, the indicators used to assess pain and the impact of a range of drugs with pain-relieving properties. We report that there are several behavioural indicators that can be used to determine pain, including reduced activity, space use and distance travelled. Pain-relieving drugs prevent these responses, and we highlight the dose and administration route. To minimise or avoid pain, several refinements are suggested for common laboratory procedures. Finally, practical suggestions are made for the management and alleviation of pain in laboratory zebrafish, including recommendations for analgesia. Pain management is an important refinement in experimental animal use and so our report has the potential to improve zebrafish welfare during and after invasive procedures in laboratories across the globe.
Examining the role of speaker familiarity and statement practice on deception detection
Authors: Cash Daniella K. , Spenard Kayla D. , Russell Tiffany D.
Published: December 2023

Detecting deception is a ubiquitous, but difficult component of daily interactions. While prior work has shown that people are poor lie detectors, research has also shown that increased familiarity with the statement sender impacts accuracy. The current study examined how increased familiarity with a statement sender, as well as the type of statement provided, influenced detection accuracy. Participants judged truthful and deceptive statements from different speakers that varied in how familiar they were to the participant (pre-experimental familiarity, experimental familiarity, no familiarity). The statements that were evaluated varied in veracity, statement type (descriptions or denials), and whether the statements had been practiced. Participants believed they were more accurate in their veracity assessments for the pre-experimentally familiar speakers compared to the other speaker types. While participants were more accurate for pre-experimentally familiar speakers compared to strangers, there was no difference in accuracy between judgments for the pre- and experimentally familiar speakers. Participants were also more likely to believe statements that had been practiced, regardless of the statements’ actual veracity or their degree of familiarity with the speaker.
Demyelinating polyradiculoneuropathy during dabrafenib and trametinib treatment for metastatic melanoma: A case report
Authors: Venturelli Marta , Greco Stefano , Baldessari Cinzia , Pugliese Giuseppe , Depenni Roberta , Dominici Massimo
Published: December 2023

Background:

Melanoma is an aggressive malignancy, historically characterized with a poor prognosis and few treatment options. The advent of target therapy with BRAF and MEK inhibitors, as well as immunotherapy, changed this scenario and improved the prognosis of patients with BRAF V600E mutation. These therapies are generally well tolerated. Neurological toxicities, especially polyradiculopathy, are very rare with BRAF inhibitors and MEK inhibitors although some cases have been described in recent years, regardless of the type of target therapies combination used.

Case report:

We report the case of a patient with BRAF V600E-mutated metastatic melanoma treated with dabrafenib and trametinib who has developed a demyelinating polyradiculoneuropathy.

Conclusion:

This case, once more, should draw our attention to the possibility of rare, but potentially serious side effects, even in the case of generally well-tolerated treatments. Especially in the presence of side effects, it is important a close relationship between clinicians and patients for the management of adverse events and the choice of the best treatment strategy.
Determination of Four Chemical Components in Qishen Yiqi Dripping Pills by UPLC-MS/MS Method
Authors: Lili Qin , Honglian Zhang , Yanxia Wang , Yingying Liang , Qiang Li , Xuerong Xie
Published: December 2023

Background

In this study, the ultrahigh performance liquid chromatography mass spectrometry/mass spectrometry (UPLC-MS/MS) method was established to test the contents of protocatechuic acid (C7H6O4), salvianolic acid B (C36H30O16), rosmarinic acid (C19H14O3), and cryptotanshinone (C19H20O3) in Qishen Yiqi dripping pills.

Materials and Methods

Methanol was chosen as the solvent according to a certain material–liquid ratio as a solution, and the ultrasonic extraction method was used to prepare the sample solution. UPLC-MS/MS was used to complete a quantitative analysis of the contents of Qishen Yiqi dripping pills. Then, the chromatographic conditions were shown as follows. The stationary phase was Agilent ZORBAX SB-C18 (2.1 mm × 100 mm, 1.8 µm), and the mobile phase was acetonitrile–0.1% formic acid water. The column temperature was 40℃, the injection volume was 3 µL, and the flow rate was 0.2 mL⋅min–1. Finally, the determination method was built to test four chemical constituents under the multiple reaction monitoring (MRM) analysis mode.

Results

The retention times of protocatechuic acid, salvianolic acid B, rosmarinic acid, and cryptotanshinone were 1.26, 1.32, 1.35, and 6.76 min, respectively. In addition, the concentration ranges of four compounds were 0.25–2.0 µg⋅mL−1, 10.0–50.0 µg⋅mL−1, 5.0–50.0 µg⋅mL−1, and 1.0–10.0 µg⋅mL−1, respectively. And the standard curve showed a good linear relationship in a reasonable range ( r2 ≥ 0.9950). The average recovery rate was from 96% to 124%. The contents of protocatechuic acid, salvianolic acid B, rosmarinic acid, and cryptotanshinone were 0.12%–0.022%, 17%–8.4%, and 6.5%–8.6% in seven batches of Qishen Yiqi dripping pills, which were in the range of 23%–31%. The instrument ran stably, and the method had good accuracy and repeatability (relative standard deviation [RSD] ≤ 3%). Additionally, the test result was stable within 10 h.

Conclusion

The contents of the four constituents were different among different batches. The quantitative method was established to determine the four chemical components in Qishen Yiqi dripping pills, which could provide a reference for quality evaluation in vivo.
Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats
Authors: Liu Rui , Fu Yu-Tuo , Jiang Feng-Qi , Ye Yi-Jie , Wang Shu-Ming
Published: December 2023

Background

After hypovolemic shock caused by severe burns, lipid peroxidation is an important factor in tissue edema and multiorgan dysfunction syndrome (MODS). Many studies have shown that valproic acid (VPA) inhibits lipid peroxidation and reduces tissue and organ injury.

Objectives

This study investigated whether the VPA treatment of scalded rats reduced tissue edema by inhibiting lipid peroxidation, thereby improving organ function and survival rate.

Materials and Methods

A total of 60 male Sprague-Dawley rats (weighing: 280–300 g) with a 50% total body surface area (TBSA) full-thickness dermal burn were randomly assigned to the following 3 groups (with 20 rats per group): (I) the no infusion resuscitation (NR) group; (II) the sodium lactate Ringer’s solution (LR) group; and (III) the sodium valproate Ringer’s solution (VR) group. After scalding, the following hemodynamic parameters were measured: Copper2+-Zinc2+-superoxide dismutase (Cu2+-Zn2+-SOD) activity, thiobarbituric acid reactive substances (TBARSs), oxidized glutathione (GSSG), reduced glutathione (GSH), and antioxidant enzyme activities. Organ function parameters and water content were also measured. Another 60 male Sprague-Dawley rats were used to observe the 24-h survival rate of the rats using the same scald model and fluid resuscitation.

Results

VPA significantly increased the mean arterial pressure (MAP) and cardiac output (CO), and significantly decreased the pulmonary vascular permeability index (PVPI) and extravascular lung water index (ELWI). VPA also increased plasma Cu2+-Zn2+-SOD activity and decreased the plasma TBARS level. VPA reduced the TBARS level and GSSG in various tissues and increased the concentration of GSH. VPA decreased glutathione peroxidase (GPx) and catalase (CAT) activity, but significantly increased glutathione reductase (GR) activity in various tissues. VPA significantly improved organ functions and decreased water content. VPA significantly improved the survival rate, and the 24-h survival rate of the VR group was double that of the LR group.

Conclusion

Resuscitation with VPA reduced tissue edema, protected visceral functions, and improved the survival rate of rats with severe burn shock (BS) by alleviating lipid peroxidation.
Oncological and functional outcomes of modified arthroscopic resection for intra-articular tenosynovial giant cell tumor of the knee using multiple portals
Authors: Higa Kotaro , Uehara Fuminari , Azuma Chinatsu , Oshiro Hiromichi , Tome Yasunori , Nishida Kotaro
Published: December 2023

Background

Arthroscopic resection of tenosynovial giant cell tumor (TS-GCT) presents favorable outcomes. However, there are reportedly higher recurrence rates in patients who had incomplete resection. To minimize incomplete resection, we established a multiple portal approach depending on the location of the disease. In this study, we aimed to retrospectively evaluate the clinical outcomes of arthroscopic resection for both localized and diffuse types of TS-GCT of the knee.

Methods

From 2009 to 2019, 13 patients who underwent arthroscopic synovectomy of the knee and were histologically diagnosed with TS-GCT were included in this study. The pre- and postoperative range of motion (ROM) of the knee was measured. The Japanese Orthopaedic Association (JOA) score and the Knee Injury and Osteoarthritis Outcome Score (KOOS) were assessed at the final follow-up examination. Magnetic resonance imaging was performed to detect incomplete resection or local recurrence.

Results

Among the 13 patients, seven and six had localized and diffuse type TS-GCT, respectively. Regarding the knee ROM, preoperative knee flexion in patients with the localized type was limited compared with that in those with the diffuse type. However, the ROM was significantly improved in patients with both types postoperatively. The JOA score and KOOS of patients with both types at the final follow-up were favorable, and there were no significant differences between both types. There was neither recurrence nor incomplete resection in any patient for both types.

Conclusion

All patients, regardless of the TS-GCT type, achieved favorable outcomes after arthroscopic surgery; especially, the failure rate was 0%.
Study on the long-distance settlement threshold of high-speed railway subgrade based on vehicle responses
Authors: Li Zheng , Wang Weidong , Xu Lei , Xu Jingmang
Published: December 2023

The long-distance and large-scale subgrade settlement is a key issue in high-speed railway (HSR). This work focuses on the long-distance settlement threshold for the HSR subgrade. A Green’s function-based hybrid dynamic model with high efficiency is established to achieve the long-distance analysis of the vehicle-track-subgrade interaction system with a wide range of subgrade settlement. Based on the analysis results, the Wavelet decomposition technique is applied to extract the low-frequency components of vehicle responses excited by the additional deformation of rails induced by the long-distance subgrade settlement. The simulation results show that the low-frequency vibrations of vehicle are mainly excited by the additional deformation of rails induced by settlement. Based on the correlation between the vehicle responses and the second derivative of additional deformation of rails, the threshold of long-distance settlement can be determined. The vehicle response and subgrade settlement signal are linked in the time-frequency domain, and the relationship between system excitation and response is clearly revealed. This paper provides a referenceable analysis framework that is convenient for engineers in the control for the amplitude of large-scale subgrade settlement in HSR.
Walk your reputation: The impact of corporate social responsibility decoupling on the hospitality and tourism firm value in the time of crisis
Authors: Wang Kewen , Yu Yongqi , Wang Xin , Zheng Haidong
Published: December 2023

A growing body of research has tested the protective effect of pre-COVID-19 CSR reputation or during-COVID-19 CSR action for hospitality and tourism firms but has obtained inconclusive results. These inconclusive results may have been because of the decoupling of during-COVID-19 CSR action from pre-COVID-19 CSR reputation. From the perspective of institutional theory, we use a sample of Chinese hospitality and tourism listed firms during the COVID-19 pandemic and a cluster-adjusted panel data regression with robust standard errors to reveal that the decoupling of a firm’s during-COVID-19 CSR action from its pre-COVID-19 CSR reputation negatively impacts firm value, and the negative impact is amplified for firms under stronger stakeholder scrutiny. Our findings could contribute to institutional theory by proving that decoupling is under close stakeholder scrutiny during crises and by identifying a specific type of CSR decoupling, and could offer practical implications for firms to protect their firm values during crises.
Narrative authority in online video: Legacy media and digital native production styles
Authors: Bock Mary Angela , Assaf Christopher T , Richardson Robert J , Tsyrenzhapova Dariya
Published: December 2023

This project examines the way journalists establish narrative authority in online video news through their strategic uses of epistemological production elements. Journalists have historically constructed video news stories with a combination of linguistic and photographic epistemic components to assert their role as authoritative arbiters of factual reality. Online news makes extensive use of video, but production formats and their associated epistemic strategies vary, largely in accordance with the traditions and values of different organizations. This study represents one part of a larger content analysis of video news narrative. It examines the epistemological choices in online video news narratives as produced by legacy print organizations (LP), TV stations (TV), or digital natives (DN). The results show that legacy traditions still divide print and TV organizations, while authority in DN video is constructed in a more diffuse and participatory style reflective of online culture.
“Like A Mouse Pursued By the Snake”: A Qualitative Metasynthesis on the Experiences of Revictimization Among Women Survivors of Childhood Sexual Abuse and Partner Violence
Authors: Girard Marianne , Fernet Mylène , Godbout Natacha
Published: December 2023

A metasynthesis was performed on 15 qualitative studies to document the experience of revictimization by an intimate partner among women, based on survivors’ perspectives on their sustained childhood sexual abuse and intimate partner violence victimization. Results identified two main conceptual categories: (a) Barriers to action: A belief system reflecting learned helplessness that hinders women’s abilities to protect themselves and prevent further abuses, and (b) Broken internal compass: Cognitive elements blurring women’s risk evaluation capacities and reference points limiting their ability to break the cycle of revictimization. These findings support the need to examine cognitive distortions and false beliefs in intervention practices and suggest valuable guidelines for practitioners. As the responsibility for violence always lies with the perpetrator, this study should not be interpreted as blaming women for their victimization, but instead, as a way to give women a voice about their experiences and give them a sense of power in the prevention of violence.
Disability Justice and Access on the College Campus: An Uphill Battle Toward Organizational Change
Authors: Susi-Dittmore Danielle
Published: December 2023

Feeling the exhaustion of multiple disability-related violations occurring in the classroom, staff from the Office of Disability Access at Heneton College have begun to feel isolated and hopeless. When the opportunity for collaborative, college-wide disability-centered training becomes available, it is met with mixed reviews and lots of opinions from across the institution. Some are supportive, many are feeling the pressure of multiple professional development and training obligations, and some question why the institution even needs this kind of training. Leaders in this case are faced with questions around shared governance, organizational change, and equity and inclusion.
Competence-based approaches in curricula: A comparative analysis of Russian and Chinese commercial vocational education and training programmes
Authors: Chen Pujun , Goncharova Anastasia , Li Junmin , Frommberger Dietmar
Published: December 2023

In recent decades, Competence-Based Education (CBE), which emerges to promote the competence development of learners, has been recognized as a pivotal framework, initiating paradigm shifts in Vocational Education and Training (VET) across the globe. Notwithstanding critiques regarding conceptual limitations and its association with neoliberal models of education, the concept of CBE is widely adopted in the VET systems of many countries. However, there is the dearth of empirical evidence about how this concept is implemented into educational practice within the national VET contexts, in which the CBE concept is introduced and regarded as initiative of VET modernization. Against this background, this study investigates the implementation of the approaches to competence orientation (also called competence-based approaches, abbr. CBA) in the curricula of commercial VET programmes in China and Russia, specifically focussing on Accounting and Logistics. Through qualitative content analysis, the study illuminates features of the CBA embedded in curricular documents at both national and institutional levels within these countries. The comparison of the results highlights potential similarities and distinctions regarding the realization of the CBE concept into educational practice of VET between both countries. The comparative findings reveal significant alignment with labour market needs, yet differences emerge in the principles regarding competence-based teaching and learning between both countries. While Chinese VET programmes showcase more individualized embedment of the CBA in different institutions, greater standardization of the CBA embedment evident in Russian VET curricula. These findings underscore the influence of national contexts in shaping the interpretation and application of global educational trends, offering nuanced insights for policymakers and educators looking to optimize the realisation of the CBA within VET curricula.
Investigating young people’s involvement in participatory budgeting
Authors: Farahmandpour Hoda , Zrudlo Ilya
Published: December 2023

It is widely believed that assisting young people to participate in community affairs is a potent way to contribute to both youth and community development. One way in which youth can become involved in their communities is through participatory budgeting (PB) processes. This study investigates young people’s understanding of, and experience with, the PB process organized by Toronto Community Housing in Canada. The findings of our qualitative study suggest that some youth understand the primary purpose of PB to be the betterment of the community as a whole; that motivation to become involved can be enhanced through appropriate identity-formation and adult support; and that youth can serve as a litmus test for the fairness of the deliberative practices associated with PB.
End of life care at home: The role of critical care transfer services
Authors: Sudunagunta Varun , Singh Neeraj , Khan Pervez , Beaumont Peter O
Published: December 2023

Background:

Most people would rather die at home than in hospital but only 18% of patients do so. Palliative care focuses on the physical, spiritual and psychosocial wellbeing of patients and their families, which should include facilitating transfers home when possible. Patients can have more autonomy over their care and be surrounded by loved ones which can have a significant impact on their quality of life. In this article we describe two cases of home repatriation for palliation. Case 1 describes the transfer of a patient with difficulties and gaps in planning, but with a safe transfer ultimately. Case 2 recounts a more comprehensive planning process emphasising collaboration between teams.

Benefits and difficulties of palliative critical care transfers:

Facilitating home-based care aligns with patients’ desires for familiar surroundings and emotional support. A secondary benefit is that releasing a bed space allows another patient to receive critical care treatment. Challenges of palliative critical care transfers include needing a highly trained team and thorough planning. Early discussion with the family and community palliative care teams makes this a more feasible option for patients.

Conclusion:

A multidisciplinary team of hospital and community healthcare professionals working with the patient and their family can facilitate the transfer from intensive care to allow them to die at a place of their choosing. We should aim to fulfil these wishes at the end of life as it can greatly improve the patient’s and their family’s physical and emotional wellbeing during this difficult time.
Mindfulness-based cognitive therapy for mathematics anxiety among school adolescents: A randomised trial
Authors: Nzeadibe Augustina Chinyere , Egara Felix Oromena , Eseadi Chiedu , Chukwuorji JohnBosco Chika
Published: December 2023

This study investigated the effect of mindfulness-based cognitive therapy (MBCT) on mathematics anxiety among students in Nigerian secondary schools. Eighty-six senior secondary class one students (aged 15–16 years) participated, comprising 43 students allocated to the experimental group and 43 students allocated to the control group. Mathematics anxiety was measured using the Mathematics Anxiety Rating Scale (MARS). The experimental group participated in a MBCT intervention, whereas the control group underwent conventional counselling. Both conditions lasted 6 weeks and included 12 sessions, 90 min each. Results revealed that MBCT reduced students’ mathematics anxiety from pre- to post-test, and the effect remained consistent at follow-up, compared to the control group. One of the recommendations was that teachers should be trained in applying MBCT to anxious mathematics students to remove the fear response of mathematics.
Understanding the relationship between digital game addiction, academic motivation, classroom engagement and selfishness
Authors: Karaoglan Yilmaz Fatma Gizem , Yilmaz Ramazan
Published: December 2023

Today, due to the increasing interest in hybrid education environments and technology integration into the course, mobile devices have started to be used in face-to-face classroom lessons. In addition to the many advantages of using mobile devices in the classroom, it also leads to some undesirable situations. One is related to developing students’ habits of playing digital games during the lesson. This research aimed to determine the relationship between students’ digital game addiction and selfishness, one of the individual differences, on their academic motivation and classroom engagement. Participants were 860 high school students in grades 9 to 12. The research used a correlational design. The result of a path analysis revealed that selfishness was related to digital game addiction; as the level of selfishness of the students’ increased, the probability of digital game addiction also increased. Also, digital game addiction was associated with academic motivation and was not related to classroom engagement, such that, as academic motivation levels of the students increased, the classroom engagement levels also increased. Recommendations for what can be done to increase the students’ academic motivation and classroom engagement are discussed.
Identification of Potential Causes for Increased Central Line Associated Bloodstream Infection Rates in the NICU
Authors: Parker Angela , Nolan Mark , Drews Frank
Published: December 2023

The University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI’s. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per year. The goal of this study was to identify potential contributing factors leading to this substantial increase. To conceptualize these factors, we focused on the emergence of safety conflicts during the intravenous medication administration process. A safety conflict was defined as an interference between two separate pathways designed to protect the integrity of patient care (a ‘safety pathway’). A total of 30 structured health care worker observations of the intravenous medication administration process were conducted. Data analysis shows a notable increase in safety conflict frequency, and necessary LCs as the number of medications per administration event increases. Conversely, the average duration of a single vs. two medication administration events does not significantly increase, which indicates substantial batching of tasks. This batching increases the likelihood of safety conflicts, negatively affecting patient safety.
Was I thinking about thinking about the task? Measurement issues with self-reports of task-related and task-unrelated thoughts
Authors: Helton William S. , Jacksonil Kenneth
Published: December 2023

In two studies we examined participants self-reports of their cognitive state after performing tasks. The reports of cognitive state included separate single item measures of task-related and task-unrelated thoughts framed as opposing sets (thoughts about X and –X). In study 1, we examined two data sets from previously published research. The correlation between task-related and task-unrelated thoughts was ~ r = −.25. In addition, the two items loaded onto separate factors when they were combined with other measures from the Short Task Relevant Evaluation of Stress State (STRESS). In study 2, 33 participants played a simulated natural disaster strategy game for five sessions and after each session they self-reported their cognitive state during the game. The correlation between task-related and task-unrelated thoughts at the individual level was also low, ~r = −.24. Participants may have difficulties accurately rating their thought content post-engaging in a task.
Osteovascular Conflicts in the Neck Region and Cerebrovascular Events: Illustrative Cases and Literature Review
Authors: Correia Pamela Noella , Meyer Ivo Alexis , Michel Patrik
Published: December 2023

Study design

Literature Review.

Objective

Abnormal bone structures in the neck can cause headache, neck pain, and difficulty swallowing, but also cerebrovascular events. We introduce the term “osteovascular conflicts” to describe this phenomenon. The objective of this study was to conduct a literature review of such conflicts involving the anterior and posterior cerebral circulation. Furthermore, we aimed at presenting additional illustrative cases from our institution both for increasing awareness for unusual osteovascular conflicts, and for assessing the practice and care of such patients.

Methods

We focused on osteovascular conflicts in the neck leading to cerebrovascular events related to an abnormal bone structure causing arterial or venous compression, dissection, and/or occlusion. We excluded pure vascular forms without cerebrovascular repercussions. Our PubMed/MEDLINE search for articles published in any language and for which an English abstract was available (from 1966 to 2022) included Eagle’s neurovascular, bow hunter’s syndrome, and golfer’s stroke, excluding trauma-induced artery dissections or compressions and those concerning systemic bone disorders. We also provided illustrative cases collected by the authors.

Results

All studies were either case reports or small case series. We found 82 cases of Eagle’s neurovascular, 258 of bow hunter’s syndrome, and 17 golfer’s stroke cases. Mean ages were 52, 48, and 47 years, respectively. Male predominance was evident: 81% for Eagle’s, 74% for bow hunter’s, and 93% for golfer’s.

Conclusion

Osteovascular conflicts are rare but important causes of cerebrovascular events and often go unrecognised. A greater awareness of cerebrovascular symptoms related to these conflicts can facilitate early diagnosis and treatment.
Towards a study of everyday geographic information: Bringing the everyday into view
Authors: De Sabbata Stefano , Bennett Katy , Gardner Zoe
Published: December 2023

Events are the driving force behind social media, whether we try to create them or keep up with them. A wide range of studies has focused on how content from social media can be used to detect, model and predict events and identify key topics of discussion. At the same time, very limited attention has been given so far to the quantitative study of the everyday, which has fascinated qualitative human geography research in the past few decades. That is partly due to the lack of a formal definition of what constitutes the everyday. In this paper, we aim to advance our understanding of the everyday, not by reducing it to any kind of definition but by bringing it into view through a quantitative analysis. We hypothesise that the by-products of current methods focused on event detection might be used to quantitatively explore everyday geographies as represented through Twitter data. We consider the use of both statistical approaches based on term frequency and state-of-the-art large language models, and we conduct a case study on content posted on Twitter and geolocated in the city of Leicester. Our paper makes two key advances for research concerned with the everyday and the analysis of geographic information. First, we illustrate how large language models combined with spatial analysis and visualisation can foster the study of everyday geographies, providing an insight into the still elusive concept of the everyday, representing what other approaches to the everyday have struggled to qualify. Secondly, we showcase the potential held by large language models and visual analytics in democratising sophisticated natural language processing and thus providing new tools for research in human geography.
Bridging therapy with axicabtagene ciloleucel for large B-cell lymphoma: results from the US Lymphoma CAR-T Consortium
Authors: Jain Michael D. , Jacobs Miriam T. , Gao Feng , Nastoupil Loretta J. , Spiegel Jay Y. , Lin Yi , Dahiya Saurabh , Lunning Matthew , Lekakis Lazaros , Reagan Patrick , Oluwole Olalekan , McGuirk Joseph , Deol Abhinav , Sehgal Alison R. , Goy Andre , Hill Brian T. , Andreadis Charalambos , Munoz Javier , Chavez Julio C , Bennani N. Nora , Rapoport Aaron P. , Vose Julie M. , Miklos David , Neelapu Sattva S. , Locke Frederick L. , Ghobadi Armin
Published: December 2023

During the manufacturing period of autologous chimeric antigen receptor (CAR) T-cell therapy, patients may experience a decline in their condition due to cancer progression. In this study, we investigated the impact of bridging therapy (BT) on the outcome of patients with relapsed/refractory large B-cell lymphoma who received antilymphoma treatment between leukapheresis and axicabtagene ciloleucel (axi-cel) infusion. We conducted our analysis using data from the multicenter US Lymphoma CAR-T Consortium, with a median follow-up of 33 months (range, 4.3-42.1). Out of the 298 patients who underwent leukapheresis, 275 patients received axi-cel. A total 52% of patients (n = 143) who received BT had a higher baseline risk profile than patients who did not receive BT, and these patients, as a group, had inferior outcomes compared with those who did not receive BT. However, after propensity score matching between the 2 groups, there were no statistically significant differences in overall response rate (77% vs 87%; P = .13), complete response rate (58% vs 70%; P = .1), progression-free survival (hazard ratio [HR], 1.25; P = .23), and overall survival (HR, 1.39; P=.09) between the BT group and the no-BT group, respectively. Analyzing the effects of BT in the whole cohort that underwent leukapheresis regardless of receiving axi-cel (intention-to-treat analysis) showed similar results. Radiation BT resulted in outcomes similar to those observed with nonradiation BT. Our findings suggest that BT may be safe without a significant impact on long-term survival for patients who require disease stabilization during the manufacturing period. Moreover, our results suggest that there is no clear advantage to using radiation-based BT over nonradiation-based BT.