bluuebunny/crossref_metadata_2025 huggingface dataset:
Climate Change and Its Importance to the Vertical Distribution of Rhynchocypris kumgangensis (Cypriniformes: Cyprinidae) in Deogyusan National Park
Authors: So Soonku , Cho Yun-Jeong , Jang Ji Eun , Yoo Su-Hyang , Kim Jae-Goo
Published: October 2024

Rhynchocypris kumgangensis, endemic to Korea, is limited to the upper Hangang River and Gucheondongcheon Stream. As a key and climate-sensitive biological indicator species in Deogyusan National Park, it has a southern range limit in the Gucheondong Valley. Due to climate change, notable shifts in the activity, vertical distribution, and population of R. kumgangensis in the Gucheondongcheon Stream are expected. Owing to the rapidly changing climate, significant changes in the activity, vertical distribution, and population size of R. kumgangensis in the Gucheondongcheon Stream are anticipated, and continuous surveys of the distribution of R. kumgangensis in this river area have been conducted. This study assessed the habitat of R. kumgangensis at 13 sites, including five in the Gucheondongcheon Stream, from July to October 2020 and compared the results with historical data to evaluate the impacts of climate change. At the five Gucheondongcheon Stream sites, 102 individuals were recorded from April to October 2020, and 378 were recorded between June 2018 and July 2019. Additionally, the subdominant species shifted from R. kumgangensis (2014–2018) to Zacco koreanus (2020). In the two southernmost Gucheondongcheon Stream sites, only 18 R. kumgangensis were observed in 2020 compared to 82 in 2019, indicating a significant population decline.
"Linearity Study for a Developed Spectrophotometric Visible (VIS) Analysis of Sodium Valproate from Tablets"
Authors: Gavat Cristian-Catalin , Marculescu Afrodita Doina
Published: October 2024

Sodium valproate is a established antiepileptic drug of first choice, primarily used to treat epilepsy, but also bipolar disorder and prevent migraine headaches. Valproate increases concentrations of gamma-aminobutyric acid in the brain, due to inhibition of enzymes responsible for the catabolism of gamma-aminobutyric acid. Main goal of this research consisted in the optimization and development for a new sensitive spectrophotometric quantitative analysis method of sodium valproate from tablets in the Visible field. Following the quantitative color reaction of sodium valproate with diazonium salt of alpha naphthylamine in alkaline medium, a light yellow azo dye was formed and spectrophotometrically analyzed at the wavelength of 386 nanometers. The amount of pure sodium valproate found on pharmaceutical extended-release tablet was 492.578 milligrams compared to the official declared pure amount of 500 milligrams on prolonged-release tablet. Amount found was assigned to a percentage content of 98.5156 percent pure sodium valproate in a pharmaceutical tablet. Mean average percentage error (deviation) from the officially stated value was about 1.4844 percent, which was included within normal limits, below five percent maximum limit allowed by European and Romanian Pharmacopoeias rules (5 percent). Spectrophotometric method was subjected to the statistical validation procedure and was successfully validated. Linear regression was analyzed. Method presented a very good linearity over the entire concentrations range 0.16 – 2.08 microgram on milliliter. Linear regression coefficient R square was 0.999330 and the correlation coefficient R was represented by 0.999665, were within the normal ranges of values.
Water Sorption Properties and Hydrothermal Stability of Al-Containing Metal-Organic Frameworks Cau-10 and Mil-96 Studied Using Quasi-Equilbrated Thermodesorption
Authors: Makowski Waclaw , Gryta Patrycja , Jajko-Liberka Gabriela , Cieślik-Górna Monika , Korzeniowska Aleksandra
Published: October 2024

A novel experimental technique, quasi-equilibrated temperature-programmed desorption and adsorption (QE-TPDA) was used to study the water sorption properties and hydrothermal stability of aluminum trimesate MIL-96 and aluminum isophthalate CAU-10, which have been selected due to their remarkable sorption properties. The QE-TPDA profiles of water observed for MIL-96 and CAU-10 confirmed the hydrophilic nature of these materials. Complex QE-TPDA profiles indicate that water sorption in MIL-96 follows a three-step pore filling mechanism. The shape of single desorption peaks in the QE-TPDA profiles for CAU-10 confirms that water sorption involves a reversible phase transition. Based on the QE-TPDA profiles, the water adsorption heat were determined: 45-46 kJ/mol for CAU-10 and 43-56 kJ/mol for MIL-96, in the latter case depending on the adsorption extent. Hydrothermal stability tests revealed that MIL-96 retained its stable porosity-related sorption capacity for water after hydrothermal treatment up to 290°C. Gradual changes in the QE-TPDA profiles due to the hydrothermal treatment above 290°C, with decreasing the high-temperature desorption peak and increasing the low-temperature one, indicate minor structural changes occurring in this material. Only after 410° C treatment was fast degradation of MIL-96 observed. CAU-10 exhibited high and unchanged hydrothermal stability up to 400°C.
II. Laplace-like Phase Angles to Facilitate Libration Searches in Multiplanetary N-body Simulations
Authors: Christodoulou Dimitris M. , Sorabella Nicholas M. , Bhattacharya Sayantan , Laycock Silas G. T. , Kazanas Demosthenes
Published: October 2024

We describe a method of determining three-body and four-body Laplace-like phase angles with the potential to librate about a mean value in multiplanet extrasolar systems. Unlike in past searches of N-body results, this method relies on global mean-motion resonances (MMRs) and takes into consideration the location of the most massive planet which defines the 1:1 global MMR in each (sub)system. We compile lists of potentially librating phase angles and prevalent MMRs in 35 real multibody systems, and we discuss their properties in conjunction with recent investigations of librations discovered in sophisticated N-body simulations. We hope that our results will facilitate systematic libration searches in dynamical models of compact systems with three or more orbiting bodies.
Can AI Technologies Support Automating Clinical Supervision? Assessing the Potential of ChatGPT
Authors: Cioffi Valeria , Ragozzino Ottavio , Mosca Lucia Luciana , Moretto Enrico , Tortora Enrica , Acocella Annamaria , Montanari Claudia , Ferrara Antonio , Crispino Stefano , Gigante Elena , Lommatzsch Alexander , Pizzimenti Mariano , Temporin Efisio , Barlacchi Valentina , Billi Claudio , Salonia Giovanni , Sperandeo Raffaele
Published: October 2024

Clinical supervision is an essential element in trainees, preventing burnout and ensuring the effectiveness of their intervention. AI technologies offer increasing possibilities for the development of clinical practices, among it supervision appears to possess the ideal characteristics for automation processes.
In this study we test the capabilities of ChatGPT-4 to provide supervisory feedback by then placing them in comparison with feedback produced by a qualified supervisor.
Two ChatGPT-4-generated feedbacks (the first one produced by a naïve identity and the second one by a trained identity) and one human-produced feedback were evaluated by means of a liking questionnaire, which was filled out to a group of gestalt psychotherapy trainees.
Principal Component Analysis (PCA) highlighted 4 components of the questionnaire: relational and emotional dimensions (C1), didactic and technical quality (C2), treatment support and development (C3), and professional orientation and adaptability (C4). The ratings of satisfaction, obtained from the three supervisory feedbacks, were compared by applying 1-way analysis of variance (ANOVA). Statistical evaluations were performed using the statistical package SPSS version 25.
The feedback generated by pre-trained AI (f2) was rated significantly higher than the other two (untrained AI feedback (f1) and human feedback (f3) in C4; in C1 the superiority of f2 over f1 but not over f3 appears significant.
These results suggest that the use of pre-trained AI may be an appreciable option for increasing the effectiveness of clinical supervision in some specific areas, including especially career guidance.
Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
Authors: Cuenca Victor Ezequiel , Pedroni Viviana Isabel , Morini Marcela Ana
Published: October 2024

In this study, we present a multicomponent lipid model membrane composed of six lipids, in-cluding cholesterol, which represent the structure of neuronal membranes found in grey matter. To our knowledge, no previous studies have attempted a model like this. We constructed our model membranes using an esterified form of the most abundant polyunsaturated fatty acid found in grey matter: docosahexaenoic acid (DHA). It is the most prevalent fatty acid in the brain and is essential for maintaining cellular structural integrity, acting as a major phospholipid in neural membranes. The aim of this work is to analyse the effects that different proportions of DHA have on the proposed membrane model. For this purpose, transmission electron microscopy, zeta potential, and molecular acoustics were used. The results showed differences that may be attributable to the influence DHA has on the nanodomains of sphingomyelin and cholesterol.
Adverse Events as a Function of Biologic Sex in a Multicenter Clinical Trial of Melanoma Vaccines
Authors: Lyons Catherine Elisabeth , Jin Ruyun , Smith Aaron Dayne , Zhu Hong , Slingluff, Jr Craig L
Published: October 2024

Background/Objective: Biological females experience more autoimmune disease than males and more treatment-related adverse events (TRAEs) after immune checkpoint blockade therapy. However, little is known about sex-related differences in TRAEs after cancer vaccines.
Methods: The Mel44 clinical trial (NCT00118274) enrolled patients with high-risk melanoma to either of two melanoma vaccines. We hypothesized that females would experience higher rates and grades of TRAEs. TRAE rates and grades were compared between sexes, with adjustment for multiple comparisons, and with mixed-effects models.
Results: Multiple sex-related differences in TRAE rate and grade were observed in unadjusted comparisons, but only hyperglycemia and hypopigmentation were significantly higher grade by sex after correcting for multiple comparisons: they were increased in males. In mixed-effect mod-els, vaccination strategy, but not patient sex, was independently associated with TRAE rates and grades. Conclusions: These data do not support our hypothesis that TRAEs would be increased in females. Vaccine safety was supported for both males and females.
A Novel Optimization Method via Box-Behnken Design Integrated with Back Propagation Neural Network – Genetic Algorithm on Hydrogen Purification
Authors: Zhang Nannan , Hu Sumeng , Xin Qianqian
Published: October 2024

High purity hydrogen is a necessary need for fuel cell. Pressure swing adsorption (PSA) technology is one of the effective methods for hydrogen purification and separation. A layered adsorption bed packed with activated carbon and zeolite 5A for five-component gas mixture (H2/CH4/CO/N2/CO2=56.4/26.6/8.4/5.5/3.1 mol%) PSA model was built. The model was validated by breakthrough curves and comparing the results with the experimental data. The purification performance of six-step layered bed PSA cycle was studied using the model. In order to optimize the cycle, the Box-Behnken design (BBD) method was used, as implemented in Design Expert™. In addition to adsorption time, the pressure equalization time and the feed flow rate were considered as independent optimization parameters. Quadratic regression equations were then obtained for three responses of the system, namely purity, recovery, and productivity. To explore a better optimization solution, a novel optimization method of machine learning with back propagation neural network (BPNN) was proposed in this work, a kind of heuristic algorithm of genetic algorithm (GA) is introduced to optimize the structure of BPNN. The predicted outputs of hydrogen production using two kinds of models based on back propagation neural network-genetic algorithm (BPNN-GA) and BBD method integrated with BPNN-GA (BBD-BPNN-GA) models. The results showed that the BBD-BPNN-GA model have a better performance with the mean square error (MSE) of 0.0005, while the MSE of BPNN-GA model was 0.0035. And the correlation coefficient of R-values were much closer to 1 of the BBD-BPNN-GA model, which was illustrated that the BBD-BPNN-GA model can be effectively applied to the prediction and optimization of PSA process.
Gold Nanoparticles: Multifunctional Properties, Synthesis and Future Prospects
Authors: Duman Hatice , Akdaşçi Emir , Eker Furkan , Bechelany Mikhael , Karav Sercan
Published: October 2024

Gold nanoparticles (NPs) are among the most commonly employed metal NPs in biological applications, with their distinctive physicochemical features. Their extraordinary optical properties, stemming from the strong localized surface plasmon resonance (LSPR), contribute to the devel-opment of novel approaches in the areas of bioimaging, biosensing, and cancer research, especially for photothermal and photodynamic therapy. The ease of functionalization with various lig-ands provides a novel approach to the precise delivery of these molecules to targeted areas. Gold NPs ability to transfer heat and electricity positions them as valuable materials for advancing thermal management and electronic systems. Moreover, their inherent characteristics, such as in-ertness, give rise to the synthesis of novel antibacterial and antioxidant agents as they provide a biocompatible and low-toxic approach. Chemical and physical synthesis methods are utilized to produce gold NPs. The pursuit of more ecologically sustainable and economically viable large-scale technologies, such as environmentally benign biological processes referred to as green/biological synthesis, has garnered increasing interest among global researchers. Green synthesis methods are favorable among other synthesis techniques as they minimize the necessity for hazardous chemicals in the reduction process due to their simplicity, cost-effectiveness, energy efficiency, and biocompatibility. This article discusses the importance of gold NPs, their optical and conductivity properties, antibacterial, antioxidant, and anticancer properties, synthesis methods, contemporary uses, and biosafety, emphasizing the need to understand toxicology principles and green commercialization strategies.
Comprehensive Genome-Wide Identification and Expression Profiling of bHLH Transcription Factors in Areca catechu under Abiotic Stress
Authors: Ali Akhtar , Khan Noor Muhammad , Qi Jiang Yi , Zhou Guangzhen , Wan Yinglang
Published: October 2024

The basic helix-loop-helix (bHLH) transcription factor family, is the second-largest superfamily in plants after MYB, which plays a significant role in the physiological processes of plant growth, tissue development, and environmental variation. However, the systematized study of the bHLH transcription factor family has not yet been conducted in A. catechu. Herein, we conducted genome genome-wide investigation of AcbHLH genes located on 16 chromosomes of A. catechu. A phylogenic tree was constructed to adjudge their homology of genes, and 24 subgroups were identified. Finally, we analyzed the dynamic changes of gene-expression levels of nine AcbHLH genes in response to drought and salt in leaves and roots. The expression patterns of 9 AcbHLH genes show differences in leaves and roots. Under stress conditions induced by salt and drought, AcbHLH22, AcbHLH62 and AcbHLH45 are significantly upregulated in both leaves and roots. In conclusion, this study will substantially contribute to the foundation for exploring the role of the bHLH superfamily in A.catechu in dealing with abiotic stresses.
Contribution Of Structure Learning Algorithms In Epidemiology: An Application In A Real-World Dataset
Authors: Colineaux Helene , Lepage Benoit , Chauvin Pierre , Dimeglio Chloe , Delpierre Cyrille , Lefevre Thomas
Published: October 2024

The objective was to explore the contributions and limitations of structure learning methods within an epidemiological analysis of real-world data. The specific aim was to use these networks to identify determinants of access to healthcare among various social factors. We analyzed data from the 2010 wave of the SIRS cohort, which included a sample of 3,006 adults from the Paris region, France. Healthcare utilization, encompassing both direct and indirect access, was the primary outcome. Candidate determinants included health status, demographic characteristics, and socio-cultural and economic positions. We employed a dual approach: a non-automated epidemiological method (initial expert-knowledge network and logistic regression models) and structure-learning techniques based on several algorithms, with and without knowledge con-straints. We compared the results based on the presence, direction, and strength of specific links within the produced network. Although the interdependencies and relative strengths identified by approaches were similar, the structure-learning algorithms detected fewer associations with the outcome than the non-automated method. Relationships between variables were sometimes incorrectly oriented when using a purely data-driven approach. Structure learning algorithms can be valuable in exploratory stages, helping to generate new hypotheses or mining novel databases. However, results should be validated against prior knowledge and supplemented with additional confirmatory analyses.
Emerging Cybersecurity and Privacy Threats of ChatGPT, Gemini, and Copilot: Current Trends, Challenges, and Future Directions
Authors: Arsal Muhammad , Saleem Bilal , Jalil Sommia , Ali Muhammad , Zahra Maila , Rehman Ayaz Ur , Muhammad Zia
Published: October 2024

Generative AI chatbots have emerged as a significant scientific contribution. They can produce text, images, audio, and video, and their applications are vast and varied in every field. However, it is identified that these chatbots can be used by script kiddies and malicious actors to generate phishing emails, security exploits, and executable payloads that can present notable risks and challenges for cybersecurity. This research provides an extensive review of the current status of the three most popular generative AI chatbots which are ChatGPT, Google Gemini, and Microsoft Bing. The article further reviews the different ways in which an attacker can intentionally use a chatbot for malicious activities and intensify cyber attacks. Moreover, the article provides insights on how an attacker uses certain keyword queries to manipulate chatbot behavior and tricks it into generating content that I won’t otherwise. We also explored the role of AI chatbots in enhancing cyber resilience against sophisticated attacks and their applications in detecting and mitigating security incidents. Finally, we proposed strategies that can empower modern chatbots to defend against such threats so that an attacker will not be able to bypass their content filtering mechanisms.
Effect of Short-Term High CO2 Treatments on Maintaining the Firmness of Highbush and Rabbiteye Blueberries During Cold Storage
Authors: Toledo-Guerrero Jose David , Alvarez Maria Dolores , Herranz Beatriz , Escribano M. Isabel , Merodio Carmen , Romero Irene , Sanchez-Ballesta M. Teresa
Published: October 2024

Global demand for blueberries has surged in recent years, primarily due to their health benefits. However, blueberries postharvest losses, particularly firmness loss and decay, remain significant challenges. This study applied high concentrations of CO2 (15% and 20%) for 3 days at 1 °C to highbush (Duke) and rabbiteye (Ochlockonee) blueberries to assess their effects on maintaining quality, especially firmness, during low-temperature storage. Various quality parameters were evaluated, including titratable acidity, pH, total soluble solids, weight loss, and decay. The impact of gaseous treatments on firmness was analysed through mechanical parameters and the expression of genes related to cell wall integrity (XTH23, PL8, PG, PM3, EXP4, and VcGH5). The effectiveness of the treatments varied between species. High CO2 levels successfully reduced decay in both cultivars, but only the highbush variety (Duke) showed improvements in firmness. In Duke, CO2 treatments influenced the expression of genes associated to cell wall integrity, such as XTH23, PL8, and GH5. In contrast, the roles of PG and PME in firmness maintenance were minimal, showing no significant differences between treatments. While CO2 did not enhance firmness in Ochlockonee, it effectively reduced weight loss, highlighting the need for tailored postharvest strategies for different blueberry cultivars.
Stochastic Model for a QAM Transmission Subject to the Epidemic Interference Effect
Authors: Alencar Marcelo Sampaio de
Published: October 2024

This article presents a stochastic model for the effect of interference caused by a sudden increase in the number of users that access a QAM digital cellular communication system. As demonstrated, the rapid increase in the number of users that access the system causes a non-stationary traffic in the network. A stochastic differential approach is used to model the epidemic interference effect.
Pseudo-Jahn-Teller Effect in Natural Compounds and Its Possible Role in Straintronics I: Hypericin and Its Analogs
Authors: Štellerová Dagmar , Lukeš Vladimír , Breza Martin
Published: October 2024

The distortions and instability of high-symmetry configurations of polyatomic systems in nondegenerate states are usually ascribed to the pseudo-Jahn-Teller effect (PJTE). The geometries of hypericin, isohypericin, and fringelite D were optimized within various symmetry groups. Group-theoretical treatment and (TD-)DFT calculations were used to identify the corresponding electronic states during the symmetry descent. The symmetry descent paths (up to the stable structures without any imaginary vibrations) were determined using the corresponding imaginary vibrations as their kernel subgroups starting from the highest possible symmetry group. The vibronic interaction between the ground and excited electronic states relates to an increasing energy difference of both states during the symmetry decrease. This criterion was used to identify possible PJTE. We have shown that the PJTE in these naturally occurring compounds explains only the symmetry descent paths C2v → C2 and C2v → Cs in hypericin, and the D2h → C2v, D2h → C2v → Cs, and D2h → C2h ones in fringelite D. The electric dipole moments of hypericin and its analogs are determined prevailingly by the mutual orientations of the hydroxyl groups. The same holds for the energies of frontier orbitals in these systems, but their changes during the symmetry descent are less significant.
Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands
Authors: Hugen Sanne , Limpens Citlalli , Robben Joris H. , Fieten Hille , Mandigers Paul J. J.
Published: October 2024

Background: Gastric carcinoma in the Belgian Shepherd dog varieties Tervueren and Groenendael is commonly recognized and carries a grave prognosis. Information on incidence and heritability is necessary to design an effective selection strategy against this disease.
Methods: A database of cases and controls was built including cases with tier 1 (confirmed by endoscopy or post-mortem) and tier 2 evidence of gastric carcinoma. From the database, a birth cohort from dogs born in the Netherlands in the period 2000-2010 was used, together with pedigree information to calculate heritability using a mixed models approach. Univariate linear regression was used to test the influence of gastric carcinoma status of the parents on gastric carcinoma occurrence in offspring.
Results: For Tervueren the 10-year cumulative incidence is 4.7%, for the Groenendael this was 2.1%. There was no sex predilection. The odds of gastric carcinoma were 5.0 (2.4-11.0) in offspring when at least one parent was known to be affected versus at least one parent was known to be unaffected. Heritability, based on analysis using pedigree information from 338 dogs with gastric carcinoma and 159 controls was 0.53 (se 0.15).
Conclusions: Gastric carcinoma in the Belgian Shepherd Tervueren and Groenendael has a high incidence in the Dutch population and has a strong genetic component. Because it is a late onset disease, dogs are often already used for breeding before they are diagnosed. An effective breeding strategy for reducing the incidence therefore relies on the identification of genetic risk factors influencing the development of the disease.
Health Deficits Among People Experiencing Homelessness in an Australian Capital City: An Observational Study
Authors: Gordon Susan J , Baker Nicky , Marin Tania S , Steffens Margie
Published: October 2024

People experiencing homelessness face challenges that result in poorer health outcomes compared to those in stable housing. This study provides the results from over 40 health measures that capture the general physical and mental health of a group of people experiencing homelessness aged 22 to 84 years, in an inner-city location, invited to participate in a comprehensive assessment of physical and psychological health. We found evidence of accelerated ageing, with 44.2% of people being clinically frail, 63% had poor functional movement, and 36% had pain associated with oral health. Additionally, 90.6% of participants showed health risks due to nutrition deficiencies, over half reported poor sleep quality, 55.3% reported having psychological distress, and almost half reporting fair or poor overall dental health. This study presents a path to providing a relatively easily implemented group of health assessments to help respond to a group of underlying causes for accelerated ageing, among a group of inner-city people experiencing homelessness. This work can be used to inform the prioritisation and development of community-based health services to address functional deficits that may contribute to accelerated ageing.
Vibration Foam Rolling Treatment Influence on Changes in Plantar flexors Muscle Temperature and Surface emg Activity in Amateur Athletes
Authors: Borisavljević Aleksandar , Ćosić Marko , Janković Goran , Radić Iva , Janković Dunja , Dopsaj Milivoj
Published: October 2024

Foam rolling is widespread and deeply rooted in exercise practice. Optimal duration and role of this treatment still lack scientific consensus. Relatively novel foam rolling treatment that combines vibration during application targets different muscle characteristics that are not well understood. Studies exploring this combined treatment are scarce therefore the aim of this study was to investigate the acute effects of different duration vibration (15-s, 30-s and 60-s) foam rolling treatment on muscle skin temperature and surface muscle electromyography during Maximal Voluntary Isometric Contraction. Eighteen male subjects attended the research laboratory for three experimental sessions and performed four sets of three trials of maximal isometric heel rises. Repeated measures ANOVA determined that muscle skin temperature significant difference was only found for the 30-s treatment (p = 0.013 - 0.000). For surface muscle electromyography a 30-s treatment out of all three yielded the most significant results, between pretreatment set and post treatment set1 (p=0.01) small effect size (Cohen’s d= -0.33) and pretreatment set to post treatment set3 (p=0.01) small effect size (Cohen’s d= -0.30). All treatments did not produce significant difference during Maximal Voluntary Isometric Contraction heel rises. Future studies should investigate accute effects of longer duration treatment on changes in surface muscle temperature. Muscle activity could suggest that efficiency was improved taken into account of unchanged muscle strength, also downward trend of muscle activity caused by other two treatment durations could be of significance during rehabilitation process or during activites where this is a desired and indicated goal.
Correlation Among Maternal and Infant Factors, Social Support and Breastfeeding Self-efficacy: A Cross-sectional Study in Indonesia
Authors: Ariani Dewi , Dradjat Respati Suryanto , Kumboyono Kumboyono , Zuhriyah Lilik , Wati Linda Ratna
Published: October 2024

Background: Breastfeeding self-efficacy is a critical factor influencing the initiation and continuation of breastfeeding among mothers. Low self-efficacy affects mothers’ ability to sustain breastfeeding. Several studies have investigated the factors influencing breastfeeding self-efficacy, but none have interconnected maternal, infant, and social support factors. Aims: This study aimed to measure the correlation between maternal and infant factors, social support, and breastfeeding self-efficacy. Methods: A cross-sectional approach was employed in Jember, Indonesia, among 200 breastfeeding mothers. The study population consisted of mothers 17-42 years old who were breastfeeding and who met the following inclusion criteria: mothers who have babies aged 1-6 months, term pregnancy history, wanted pregnancy, and baby weight born ≥ 2500 grams. Maternal and infant factors and social support were determined through interviews and questionnaires. Breastfeeding self-efficacy was examined using The Breastfeeding Self-efficacy Scale Short. The multiple logistic analysis was used for multivariate analysis. Results: Of a total of 200 breastfeeding mothers, 63% had low breastfeeding self-efficacy, and 59.5% of mothers did not exclusively breastfeed. The multiple logistic regression indicated that 74.2% of the factors included in the model influenced breastfeeding self-efficacy. Positive correlations were observed between breastfeeding self-efficacy and feeding type (OR=6.603), breastfeeding frequency (OR=6.220), breastfeeding intention (OR=4.993), and family type (OR=4.001). Conclusion: feeding type, breastfeeding frequency, and family support were the important factors that support breastfeeding self-efficacy.
MicroRNA Nobel Prize: A Timely Recognition, and a High Anticipation—A Detailed Analysis to Assist
Authors: Niazi Sarfaraz K. , Magoola Matthias
Published: October 2024

microRNAS (miRNAs) maintain cellular homeostasis by blocking mRNAs through binding with t-RNA to fine-tune the expression of genes across numerous biological pathways. The 2024 Nobel Prize in Medicine and Physiology for the discovery of miRNA was long overdue and now we anticipate a deluge of research work involving miRNA to repeat the history with other RNA prizes. While miRNA therapies include several complex diseases, the realization that miRNA regulates genes, its role in addressing therapies of hundreds of diseases is expected but with advancement in drug discovery tools, we anticipate faster entry of new drug entities; to promote this, we provide details of the current science, logic, intellectual property, formulations and regulatory process with anticipation that now many more researchers will deliver novel therapies based on the discussion and advice provided in this paper.
Development of Novel Imipridones with Alkyne- and Triazole-linked Warheads on the Tricyclic Skeleton, Showing Superior Ability to Eradicate PANC-1 and Fadu Cells Compared to ONC201
Authors: Czuczi Tamás , Murányi József , Móra István , Gurbi Bianka , Varga Attila , Papp Dávid , Schlosser Gitta , Csala Miklós , Csámpai Antal
Published: October 2024

Our ongoing research focuses on developing imipridone derivatives capable of complete and selective eradication of cancer cells after relatively short treatment. We have synthetized systematically designed novel hybrids and evaluated their antiproliferative activity on PANC-1 and Fadu cell lines. We have also conducted preliminary studies on the mechanism including colony formation as well as dose-response tests in HEK293T wild-type (WT) and HEK293T CLPP-/- cells. Following gradual structural fine-tuning based on high throughput screening we identified two imipridone hybrids as the most potent derivatives. Their unique substitution pattern includes N-methylated propargylamine and ferrocenyl/phenyltriazole moieties on the benzyl groups attached to opposite sides of the imipridone core. The compounds with IC50 values similar to those of ONC201 were found capable of complete eradication of cancer cells at ca. 4 M, while ONC201 treatment at even higher concentrations left 30-50% of viable cells behind. Both compounds were found to exert equal activity in WT and CLPP-/- HEK293T cells, indicating a ClpP-independent mechanism. Further development is needed to improve the tumor selectivity of the two potent imipridone derivatives in order to develop novel drug candidates that evade resistance and can be applied in a sufficiently broad therapeutic window.
Is the Anamnesis Enough to De-Label Patients with Reported Beta-Lactam Allergy?
Authors: Rozłucka Lesia , Rymarczyk Barbara , Gawlik Radosław , Glück Joanna
Published: October 2024

Background: Decision, whether to de-label patient with suspected BL hypersensitivity, is based on the risk stratification. The aim of the study was to prepare a characteristic of diagnostic risk groups and to create a model enabling the identification of the low-risk diagnostic group. Methods: We analyzed medical records of patients hospitalized due to suspected hypersensitivity to BL antibiotics. Based on the history data, patients were divided into three diagnostic risk groups, using the criteria proposed by Shenoy et al. Univariate and multivariate analysis model were used to create a diagnostic tool. Results: Among 263 patients referred for BL hypersensitivity diagnosis, 88 (33.5%) were qualified to group I, 129 (49%) to group II, and 46 (17.5%) to group III. There were significant differences between diagnostic risk groups regarding history of hypersensitivity to penicillins (p<0.001), cephalosporins (p<0.001), >1 BL (p<0.05), several episodes of BL hypersensitivity (p<0.001), medical intervention (p<0.001), documented hypersensitivity (p<0.001), time from drug intake to symptoms (p<0.001), time from hypersensitivity to diagnosis (p<0.001). 81 patients (30.8%) were de-labeled: 52 (59.8%) in group I, 27 (20.9%) in group II and 2 (4.3%) in group III. In univariate analysis, model of the low diagnostic risk group applied to the de-labeled part showed 90% specificity and 21.93% sensitivity. NPV and PPV were estimated at 72.04% and 49.53%, respectively. Multivariate model had high specificity but low sensitivity; its NPV was 76% with 68% PPV. Conclusions: The tool enabling the identification of low diagnostic risk patients based on anamnesis is not sensitive enough, to de-label patients on its basis.
PBL-based liveworksheet e-LKPD to improve critical thinking ability in 4th class primary school science learning
Authors: Triwahyudianto Triwahyudianto , Isnani Dewi Rahmah , Kumala Farida Nur
Published: October 2024

The low critical thinking ability of students in science and science learning is still not competent because learning activities still seem monotonous, teachers still do not use designing learning tools to improve critical thinking skills, especially not using interactive LKPD, therefore, researchers use PBL-based Liveworksheet software to improve critical thinking skills which aims to describe the development process, determine the level of feasibility, practicality and effectiveness of the product. This research method uses ADDIE, namely Analysis, Design, Implementation and Evaluation. Data collection techniques use test sheets and validation questionnaires on material, language, media, teacher responses and student responses. Based on these results, the PBL-based E-LKPD Liveworksheet to improve critical thinking skills is valid and practical to use for fourth grade elementary school learning activities.
Analysis of problems in planning and organizing independent curriculum in madrasah ibtidaiyah: teacher's perspective
Authors: Sigiyuwanta Recsatasha , Mustiningsih Mustiningsih , Nurabadi Ahmad
Published: October 2024

The Merdeka Curriculum, as the latest innovation in the world of Indonesian education, raises a number of problems in the process of implementing it in Madrasah Ibtidaiyah, especially for teachers. This article analyzes the problems that arise, especially related to curriculum planning and organization. The method used is a descriptive survey, data were collected from teachers at Madrasah Ibtidaiyah Negeri 2 Trenggalek. The results showed that the majority of respondents had a lack of understanding of the independent curriculum, difficulties in preparing documents and learning tools for the independent curriculum, inadequate facilities and infrastructure. Lack of participation in intensive training and technical guidance results in a lack of understanding of the substance of the curriculum being the main factor behind this problem. In the face of these challenges, a number of alternative solutions were proposed, including intensive training, comparative studies, teacher working groups, and improved technological facilities and infrastructure
Project-based learning with interactive video media to improve students' HOTS
Authors: Wibowo Setyo Ajie , Nuro Falistya Roisatul Mar'atin , Lestari Dwi Nastiti
Published: October 2024

This study aims to improve students' higher order thinking skills (HOTS) through the use of interactive video learning media in project-based learning at SDN Junrejo 2, Batu City. This class action research was conducted in two cycles, the research shows that interactive video facilitates the delivery of information so that in its application it makes it easier for students to understand the material. The importance of the role of educators in providing guidance and support was revealed in helping students in the course of learning and developing higher order thinking skills. The process of improving HOTS requires time, adaptation to the new learning model, and continuous mentoring. With the right strategy, the use of technology in learning can bring positive changes in the quality of education.
Implementation of the project to strengthen the profile of pancasila students (p5) based on local wisdom in primary schools
Authors: Sumarni Margaretha , Jewarut Siprianus , Kusnanto Kusnanto , Melati Felisitas Victoria
Published: October 2024

The Pancasila student profile has six basic principles which refer to Pancasila values. One of the themes implemented for the project to strengthen the Pancasila student profile is the theme of local wisdom, where the implementation aims to enable students to increase and develop potential based on local wisdom values ​​to support their achievement. Pancasila Student Profile. The method used in this research process is descriptive qualitative with stages of observation methods in schools, conducting interviews with homeroom teachers and school principals, as well as documentation to fulfil data completeness. The data instruments are a list of questions on the questionnaire and interview sheet. With this research, it is hoped that schools can implement projects to strengthen the profile of Pancasila students to the maximum.
Development of PjBL e-modules based on ispring suite on alternative energy sources of water for elementary students
Authors: Pratama Yogi , Kumala Farida Nur , Yasa Arnelia Dwi
Published: October 2024

The aim of this research is to implement the results of the E-Module and determine the media development, feasibility and practicality of the E-Module. The type of research used in this research is the ADDIE development model. The subjects of this research were teachers and students of class VI using the questionnaire method with data collection tools in the form of questionnaires and documentation. The research results showed that the E-Module was declared very feasible based on media experts at 97.5%, material experts at 92.5% and language experts at 95.8% so that the learning media was suitable for testing. The practicality test given by the teacher obtained 94.5%, 95.1% for students in small groups and 92.8%
Puntuación de ultrasonido de exceso venoso (VEXUS) como predictor de lesión renal aguda en pacientes con falla cardíaca descompensada. Hospital Central Fuerza Aérea del Perú
Authors:   , Paredes Gonzales Ximena Stephany
Published: October 2024

Objetivo: Determinar si la puntuación de ultrasonido de exceso venoso (VEXUS) es un predictor de lesión renal aguda (LRA) en pacientes con falla cardíaca descompensada atendidos en el Hospital Central Fuerza Aérea del Perú. Metodología: Estudio observacional, analítica de casos y controles, prospectivo. La población estará conformada por pacientes con falla cardíaca descompensada atendidos en el Hospital Central Fuerza Aérea del Perú, cuyo tamaño muestral será de 141 pacientes divididos en dos grupos, 47 si desarrollaron lesión renal aguda (Grupo caso) y 94 no la desarrollaron (Grupo control); identificado con la fórmula de casos y controles. Las variables a evaluar serán lesión renal aguda (dependiente) y puntuación de ultrasonido de exceso venoso (independiente), para hallar los datos se hará revisión de las historias clínicas. El análisis será mediante la prueba Chi cuadrado, el cálculo del Odds Ratio (OR), el análisis de regresión logística y el cálculo de OR multivariados de la regresión, considerando significancia de un 5%.
Procesos logísticos y percepción de rentabilidad en una empresa importadora de productos naturales, distrito de Miraflores (Lima-Perú), 2023
Authors:   , Utrilla Vivanco Josselyn Sonia
Published: October 2024

La presente investigación titulada “Procesos logísticos y percepción de rentabilidad en una empresa importadora de productos naturales, distrito de Miraflores (Lima-Perú), 2023” buscó determinar la relación entre los procesos logísticos y la percepción de rentabilidad en una empresa importadora de productos naturales, distrito de Miraflores (Lima-Perú), 2023. Por dicho fin, se aplicó una metodología no experimental, transeccional, correlacional-causal, con tipo de alcance correlacional, de enfoque cuantitativo, con una muestra censal de 16 colaboradores; para la recolección de datos se usó la encuesta y de instrumento el cuestionario estructurado diseñado con la escala de Likert. El estudio proporcionó información sobre los procesos logísticos y la percepción de rentabilidad de la empresa estudiada; mediante los resultados se obtuvo una significancia de 0.196, por lo cual, se aceptó la hipótesis nula y se rechazó la hipótesis alterna y se concluyó la falta de relación entre ambas variables. De igual manera, no hubo relación entre las 3 dimensiones: gestión de compras, gestión de inventarios y distribución con la percepción de rentabilidad en la empresa evaluada.
Redes sociales y la gestión del emprendimiento Lucy Boutique Spa (Lima - Perú), 2022
Authors:   , Cueva Diaz Katherine Melissa , Elguera Gonzales Erick Omar
Published: October 2024

En la presente investigación titulada, las redes sociales y la gestión del emprendimiento Lucy Boutique Spa (Lima - Perú), 2022, se buscó determinar la relación de las redes sociales con la gestión del emprendimiento de Lucy Boutique Spa (Lima - Perú), 2022, resultando una investigación de enfoque cuantitativo, con alcance correlacional, y mediante un diseño no experimental - transversal. Es importante señalar que, en la etapa de recolección de los datos se usó como instrumento a la encuesta, siendo esta de tipo cuestionario estructurado a una muestra de 285 seguidores que tiene Lucy Boutique Spa en su página de Facebook. En esta investigación se documentó información relacionada con las redes sociales y la gestión del emprendimiento Lucy Boutique; llegando a la conclusión que efectivamente hay una correlación positiva y considerable entre las redes sociales y la gestión del emprendimiento Lucy Boutique Spa (Lima-Perú), 2022. Esto se fundamenta en el rigor estadístico de un coeficiente de correlación de Rho Spearman del orden de 0.681, con un valor de significancia (sig.) igual a 0.000. Por lo que, se rechazó la hipótesis nula y se aceptó la hipótesis alterna siendo esta: Existe una relación directa y significativa entre las redes sociales y la gestión del emprendimiento de Lucy Boutique Spa (Lima - Perú), 2022.
Comunicación organizacional y estrés laboral en el área de operaciones de una Organización No Gubernamental, distrito de Santiago de Surco (Lima - Perú), 2022
Authors:   , Orihuela Espinoza Keshia Ruth , Zevallos Baldeon Manuel Junior
Published: October 2024

En la presente investigación titulada Comunicación organizacional y estrés laboral en el Área de Operaciones de una organización no gubernamental, distrito de Santiago de Surco (Lima - Perú), 2022, se buscó determinar la relación entre la comunicación organizacional y estrés laboral en el Área de Operaciones de una organización no gubernamental localizada en el distrito de Santiago de Surco (Lima - Perú) durante el 2022, la investigación fue de enfoque cuantitativo, alcance correlacional, y usó el diseño transeccional correlacional-causal. Se elaboró un cuestionario estructurado que fue aplicado a los 30 colaboradores de la organización objeto de estudio, lo que representa una muestra censal. Gracias a este análisis, se logró recopilar información sobre la comunicación organizacional y el estrés laboral dentro del Área de Operaciones de una organización no gubernamental, situada en el distrito de Santiago de Surco (Lima - Perú), en el año 2022. Los resultados obtenidos demostraron una correlación negativa entre la comunicación organizacional y el estrés laboral, indicando una relación inversa entre ambas variables. Esta conclusión se basa en el coeficiente de correlación de Pearson calculado, el cual fue de -0.391, y un nivel de significancia de 0.033. Estos resultados confirman la hipótesis alterna, la cual sostenía la existencia de una relación significativa e inversa entre las variables en estudio.
The olivine-ringwoodite transformation triggers deep slab seismicity and rheological weakening
Authors: Rikuto Honda , Kubo Tomoaki , Miyahara Masaaki , Iwasato Takuya , Mori Yuichiro , Higo Yuji , Tsubokawa Yumiko , Goto Yuta , Suzuki Akio , Shibizaki Yuki
Published: October 2024

The subducting cold oceanic plates (slabs) exhibit the paradoxical deformation behaviors of deep seismicity and rheological weakening at the mantle transition zone (MTZ, ~400–700 km depths). The high-pressure transformation in olivine, a major constituent silicate mineral, is kinetically inhibited forming the metastable olivine wedge (MOW) in the cold center of the subducting slabs. Although the transformation of metastable olivine to ringwoodite (spinel structure) has been proposed as the possible trigger for the two contrasting behaviors of cold slabs, there have been almost no direct experimental evidence so far. Here we report new experimental results on the transformation-deformation coupling processes at ~20 GPa corresponding to the MTZ pressures. Ringwoodite is produced as nano-polycrystalline lamellae (NPL) under uniaxial stress. The thin ringwoodite NPL trigger unstable slips with coseismic stress drops by superplastic flow coupled with thermal instability at ~760–860°C. The thickening of NPL at ~950–1,330°C stabilizes the localized deformation, at which the transformation is effectively enhanced utilizing their incoherent nature, leading to homogeneous superplastic flow. Thus, the superplasticity in newly-formed ringwoodite plays key roles in the transformation-deformation coupling that occurs differently with temperatures. The paradoxical deformation behaviors of MTZ slabs can be explained by the stress-induced formation of ringwoodite NPL triggering deep seismicity at low temperatures in the vicinity of MOW, and the subsequent bulk transformation leading to homogeneous weakening at higher temperatures outside MOW.