bluuebunny/crossref_metadata_2025 huggingface dataset:
CURRENTS AND MIXING ON THE SILL OF AMBON BAY MEASURED WITH DROGUES
Authors: Walman - , Anderson James Jay
Published: August 2018

Currents and mixing properties on the sill of Ambon Bay were measured with drogues. Current speed of 0.62 m/sec was observed. A mixing model suggests material released on the sill would decrease by a factor of 2 x 104 in one hour. Drogue construction and data reduction methods are described.
A COMPARISON OF SPONGE FAUNA OF EXPOSED AND SHELTERED REEF FLATS IN EASTERN INDONESIA
Authors: Amir Ichsan
Published: August 2018

A total of 116 specimens belonging to 61 sponge species were colleted from the reef flat of four different localities in Eastern Indonesia, namely : Maisel, east of Sumba, north' of Sumbawa and^ Bahuluang. The sponge species of exposed (Maisel), disturbed (Sumba and Sumbawa) and sheltered (Bahuluang) reef flats are compared using cluster and inverse analysis. The differences in composition of sponge species among those localities are described and discussed.
ULTRASTRUCTURE OF THE ENDOSYMBIOTIC DINOFLAGELLATE Symbiodinium microadriaticum LIVING IN THE SEA ANEMONE Anemonia viridis
Authors: Suharsono -
Published: August 2018

The zooxanthella, Symbiodinum microadriaticum, an endosymbiotic dinoflagellate shows variation in its ultrastructure within its population in the sea anemone, Anemonia viridis. Such variation included the number of thylakoid, the structure of inclusions and the structure of amphiesma. The string-like structure was also found in the nucleoplasm. Some zooxanthellae have a branching or double pyrenoid with two or three stalks. Under certain condition, which are not clearly understood, two or three zooxanthellae are enclosed within one very thick membrane.
STUDIES ON PLANKTON, PRIMARY PRODUCTION AND FISH IN THE INNER BRUNEI BAY
Authors: Linden Olof , Ganning Bjorn , Lindestrom Lennart
Published: August 2018

No abstract provided
MARINE CAPTURE FISHERIES POLICY FORMULATION AND THE ROLE OF MARINE PROTECTED AREAS AS TOOL FOR FISHERIES MANAGEMENT IN INDONESIA
Authors: Wiadnya D. G.R. , Mous P. J. , Djohani R. , Erdmann M. V. , Halim A. , Knight M. , Pet-Soede L. , Pet J. S.
Published: August 2018

The FAO Code of Conduct for Responsible Fisheries states that conservation and management decisions for fisheries should be based on the best scientific evidence available. Studies show that most of Indonesia's capture fisheries are either full or over-exploited. However, the fishery sector is still expected to contribute to the increase of Indonesia's GNP through an increase in total catches. Furthermore, the current practice of using catch-effort data and Maximum Sustainable Yield models to inform Indonesia’s fisheries policies is flawed, putting sustainability and long-term profitability of Indonesia's fisheries at risk. In this paper, the authors argue that to ensure the survival of Indonesia's fish stocks and fisheries: fisheries policy must shift from development-oriented management towards management for sustainability. Furthermore, fisheries managers must accept that 'untapped resources' may not exist or cannot be exploited profitably, and that any transfer of fishing effort between fishing grounds may contribute to collapse of local fisheries. Also, fisheries managers should change the management paradigm from MSY models to eco-system based management, wherein Marine Protected Areas should play an important role.
REPRODUCTIVE PATTERNS OF HOLOTHURIA SCABRA (ECHINODERMATA: HOLOTHUROIDEA) IN INDONESIAN WATERS
Authors: Purwati P.
Published: August 2018

During 1993 to 1996, reproductive aspects of Holothuria scabra, one of the commercially important holothurian species in Indonesian waters were studied, which involved populations of Ambon Bay (eastern Indonesian waters), Saugi Island (central Indonesian waters) and Lampung Bay (western Indonesian waters). Those studies were reviewed in this paper, not only to reveal general patterns of reproductive seasons of populations throughout Indonesian waters, but also to provide more knowledge on gonadaltubule-development that has been rarely investigated on Indonesian holothurians. The review showed that the development of gonadal tubules amongst populations of Indonesian H. scabra were similar. Those included that: tubules across a gonad grew for one single reproductive cycle, and each tubule had equal opportunity to release their gametes in the same spawning event. These features conformed to general characteristics of this species throughout the world, and were different from the proposed tubule recruitment model of Smiley (1988). Each observed population showed fluctuation on gonad index, and individuals with fecund and/or post spawning gonads were recorded in most sampling occasions, resulting in fluctuation of gonad index. This attribute gave clue to through-year spawning activity with more intense during one or two periods in a year.
THE EXTENDED LONGEVITY OF A SMALL CORAL REEF SERRANID; A LESSON FROM CEPHALOPHOLIS CYANOSTIGMA (BLUE SPOT ROCK COD) OF THE CENTRAL GREAT BARRIER REEF, AUSTRALIA
Authors: Mosse Jacobus W. , Davies Campbell R.
Published: August 2018

The blue spot rock cod, Cephalopholis cyanostigma, is a small common coral reef serranid that forms a significant proportion of the discarded by-catch in the Great Barrier line fishery. Samples were obtained by spear and line fishing at Orpheus Island (range 114- 294 mm FL, mean = 226 mm, n = 137) and from Pelorus Island (range 120-285 mm FL, mean = 214 mm, n = 125). Sagittal otoliths were used to obtain age-based parameter estimates for the populations at each island. Analysis of marginal increments on monthly samples suggested that a single opaque band was deposited annually during November - December. Recaptures of three fishes (9,18, and 24 years old) in July and November 1997, five years after injection of oxytetracycline, further corroborated our conclusion that band formation was annual. The maximum age in our samples of 31 years suggested that the blue spotted rock cod was one of the longest lived serranids documented to date. The von Bertalanffy growth function provided the best description of the pattern of growth for populations at both islands with high coefficients of determination (R2 = 0.86 and 0.82 for Orpheus and Pelorus islands, respectively). Female population of both sites grew relatively slow, not reaching asymptotic size until 7-10 yrs. Statistical comparisons on male and female growth patterns were not significant, however. There were significant differences in growth parameters between islands with C. cyanostigma on average growing larger at Orpheus Island (L?= 258 mm and K= 0.22) compared with Pelorus Island (L?=244 mm and K = 0.25). These age-based population parameter estimates indicated that C. cyanostigma was considerably longer lived than expected for a small coral reef serranid and further demonstrated the utility of age-based methods in studies of the demography of tropical reef fish. The implication for conservation and fisheries management of small tropical serranids is that species with similar population parameters are likely to sustain much lower levels of fishing mortality than previously thought.
EURYPEGASUS DRACONIS LINNAEUS, 1766 (GASTEROSTEIFORMES: PEGASIDAE); A NEW RECORD TO THE DERAWAN ISLANDS, INDONESIA
Authors: Peristiwady Teguh
Published: August 2018

Three specimens of Eurypegasus draconis Linnaeus, 1766 were collected in seagrass beds of Samama Island, East Kalimantan, in June 2006. It was the first record of this uncommon species that widely distributes in Indian and Pacific waters. The species was characterized by 8-9 tail rings and a spine on the dorsal side of last tail ring.
Aplikasi Geolistrik pada Pemetaan Daerah Intrusi Air Laut di Pantai Candidasa
Authors: Pujianiki Ni Nyoman , Simpen I Nengah
Published: August 2018

To know the magnitude of sea water intrusion that occurred in Candidasa area need to be mapping by using Geo-electric Method. Geo-electric method is one Geophysical method that works by injecting an electric current into the ground and then measured the potential difference it generates. Based on the data of electric current and potential difference, resistivity will be obtained in the research area. The result of sea water intrusion mapping in Candi Dasa beach area indicates that sea water intrusion has occurred but not yet on the status of conspiracy. If groundwater extraction is not restricted, the level of intrusion will continue to increase. Contour resistivity indicates that there has been a sea water intrusion in the Candidasa Tourism Area in a mild status in the southeast area at a depth of 5-10 m. The measured rock resistivity values in the study sites ranged from 0.35 to 1800 ohm.m, the seawater intrusion criteria occurred at a resistivity of 0.5 - 30 ohm.m. The results of the study are expected to give policyholders input on sea water intrusion in Candidasa Tourism area so that appropriate policy steps can be taken.
Komposisi Efektif Batok Kelapa sebagai Karbon Aktif untuk Meningkatkan Kualitas Airtanah di Kawasan Perkotaan
Authors: Salim Noor , Rizal Nanang Saiful , Vihantara Ricky
Published: August 2018

Shallow groundwater in urban areas today is no longer fully utilized directly for domestic human needs. Some of the factors that cause, among others, due to pollution of springs by household waste, too much groundwater production resulting in the reduced amount of ground water. Finally the water function as a solvent and the neutralizer of the pollutant decreases as the water becomes less clear. By utilizing coconut shells as activated carbon mixed with silica sand, zeolite, and manganesee in this research can reduce turbidity, TDS and ground water PH so that the water produced can meet clean water standards according to PERMENKES/RI No.416/IX/1990. The objective of this study was to find an effective mixture composition to purify water using 5 different mixing compositions and it can be concluded in this study that coconut shells used as activated carbon amount to 35% of total media composition. So the most optimal composition to produce water with good quality of 35% active carbon, 25% silica sand, manganese 20%, 20% zeolite. In this composition also, Mangan (Mn) and Iron (Fe) have decreased and meet the quality standard of raw water quality as required by PERMENKES quality standard of Class B water quality.
Indeks Stakeholders Pengelolaan Daerah Aliran Sungai dengan Pendekatan KISS di Indonesia
Authors: Sriyana Ignatius
Published: August 2018

Integrated watershed management (IWM) using KISS (coordination, integration, synchronisation, and synergy) method is believed to be the answer for problems lingering the integrated watershed management in Indonesia. How successful the management is depends on how capable of stakeholders are to performing coordination, integration, synchronisation, and synergy in managing the watershed. This study aimed at measuring the rates of coordination, integration, synchronisation, and synergy performed by each stakeholder by applying an "Index Rate" instrument. Research findings revealed that, simultaneously, the coordination, integration, synchronisation, and synergy obtained by the watershed management stakeholders resulted in a moderate rate (71.4). Partially, the rates obtained were as follows: moderate coordination (72.69); moderate integrity (72.50); moderate synchronisation (70.34); and moderate synergy (70.05).
KAJIAN PELAKSANAAN PENYEDIAAN UTILITAS UMUM PERKOTAAN TERPADU KABUPATEN TEMANGGUNG
Authors: Parahyang Sari Sri Kumala , Rudiarto Iwan
Published: August 2018

Dalam memenuhi pelayanan untuk masyarakatnya, maka sebuah kota terus melakukan pembangunan dan penambahan pada bagian infrastruktur terutama pada penyediaan utilitas umumnya. Kabupaten Temanggung mengalami peningkatan jumlah penduduknya tiap tahun. Hal ini membuat pemerintah daerah perlu melakukan perencanaan pembangunan serta perbaikan pada utilitas umum yang ada. Dalam penyediaan pembangunann utilitas umum menimbulkan permasalahan berupa galian utilitas umum yang tumpang tindih. Fenomena ini terjadi dikarenakan pelaksanaan penyediaan utilitas umum masih belum terintegrasi. Berdasarkan hal-hal tersebut menimbulkan pertanyaan bagaimana pelaksanaan penyediaan utilitas umum perkotaan di Kabupaten Temanggung?. Tujuan dari penelitian ini untuk melakukan pengkajian terhadap pelaksanaan penyediaan utilitas umum. Variabel yang yaitu komunikasi, kesadaran, kompetisi partisipan, kesepakatan; komitmen dan insentif koordinasi serta kontinuitas perencanaan. Metode penelitian ini adalah metode kualitatif. Setelah dilakukan penilaian pada tiap indikator, diketahui bahwa koordinasi yang terjadi antar instansi dalam SKPD cukup kuat. Hubungan koordinasi yang bersifat sedang ada pada hubungan antar SKPD - non SKPD dan instansi dalam SKPD - masyarakat. Selain itu hubungan koordinasi yang bersifat lemah terjadi pada hubungan antara instansi non SKPD - non SKPD dan non SKPD - masyarakat. Selain itu tiap aspek koordinasi memiliki besaran keterkaitan yang berbeda dengan aspek yang lainnya
The Training of Porphyry’s ‘Athlete’: The Ascetic Philosopher in On the Abstinence from Eating Flesh.
Authors: Gamlath Isha
Published: August 2018

The image of the historical athlete who enters the ancient Greek stadium is a perfect medium for clarifying the conceptual philosopher’s liberation from material bonds and ascent to the higher causal order in Porphyry’s On the Abstinence from Eating Flesh. The image is emphasized when Porphyry prescribes the practice of vegetarianism and immaterial sacrifice for the conceptual philosopher’s preparation for the specific ‘contest’of freeing from material concerns such as food and sacrifice and eventual transformation in to the as the priest of the Highest God.
Jana ze Stobnicy (1470–1519) wykład o Grecji. Inspiracje Eneasza Sylwiusza Piccolominiego (1405–1464)
Authors: Zawadzki Robert K.
Published: August 2018

The article offers insights on the reception and cultural transmission of one of the most important Renaissance texts entitled De Europa written by Aeneas Silvius Piccolomini, an Italian scholar (he became Pope Pius II in 1458). His work was adopted and adapted by the Polish scholar Jan of Stobnica. In his dissertation Introductio in Ptolemaei cosmographiam cum longitudinibus et latitudinibus regionum et civitatum celebriorum, he took up all issues of Piccolomini`s treatise, including geographical and historical aspects of Greece. His attitude to this material was very positive. The article considers the motifs of Greek districts, such as Macedonia, Thessaly, Boeotia, Attica, the Peloponnese, the Isthmus, Achaea, Acarnania, Epirus, and the significance of Greece for Polish Renaissance culture.
Spatial Analysis of Yampil Barrow Complex
Authors: Jachimowicz Kacper , Żurkiewicz Danuta
Published: August 2018

The Yampil Region represents a concentration of densely populated barrow cemeteries. Some 156 mounds figure in the available cartographic studies, which are the basis of spatial analysis presented below. The aforementioned therefore shall involve an examination of parameters for the localisation of tumuli in respect to altitude, terrain surface incline, direction of exposition and distance from waterways and watershed ridges as well as an analysis of visibility for selected sites, which shall describe preferences in respect to the chosen place of construction.
Use of wood in Yampil Barrow Complex funerary rituals IV-II mill. BC
Authors: Stępnik Tomasz , Szmyt Marzena , Żurkiewicz Danuta
Published: August 2018

This article presents the results of analyses of relics made out of wood that were discovered during the investigation of the Yampil Barrow Complex (Ukraine, Vinnitsa Oblast) in the period 2010-2015 in respect to the graves of Eneolithic communities, Yamnaya culture, Catacomb culture, Noua culture and the Iron Age. The research has documented a process of the selection of wood used in funerary rituals in the 4th to 2nd mill. BC and the choice of tree species present in stenothermal climax forests (Quercus sp., Fraxinus sp.).
Propensity Score Weighting for Causal Inference with Clustered Data
Authors: Yang Shu
Published: August 2018

Propensity score weighting is a tool for causal inference to adjust for measured confounders in observational studies. In practice, data often present complex structures, such as clustering, which make propensity score modeling and estimation challenging. In addition, for clustered data, there may be unmeasured cluster-level covariates that are related to both the treatment assignment and outcome. When such unmeasured cluster-specific confounders exist and are omitted in the propensity score model, the subsequent propensity score adjustment may be biased. In this article, we propose a calibration technique for propensity score estimation under the latent ignorable treatment assignment mechanism, i. e., the treatment-outcome relationship is unconfounded given the observed covariates and the latent cluster-specific confounders. We impose novel balance constraints which imply exact balance of the observed confounders and the unobserved cluster-level confounders between the treatment groups. We show that the proposed calibrated propensity score weighting estimator is doubly robust in that it is consistent for the average treatment effect if either the propensity score model is correctly specified or the outcome follows a linear mixed effects model. Moreover, the proposed weighting method can be combined with sampling weights for an integrated solution to handle confounding and sampling designs for causal inference with clustered survey data. In simulation studies, we show that the proposed estimator is superior to other competitors. We estimate the effect of School Body Mass Index Screening on prevalence of overweight and obesity for elementary schools in Pennsylvania.
Study of the corrosion properties in a hot forged Cu-Al-Ni alloy with added Cr
Authors: Parameswaran P. , Rameshbabu A.M. , Navaneetha Krishnan G. , Yogeshwaran R. , Ramkumar R.
Published: August 2018

Here, the corrosion properties of chromium (Cr) added to a copper-aluminum-nickel (Cu-Al-Ni) alloy were studied. Primarily, the alloy samples were prepared by increasing the percentages of Cr composition in the following series of 4%, 8% and 12% by keeping other alloying elements as constants. The alloy was made using the powder metallurgical technique. Consequently, hot forging was done on the sintered specimen. Both hypothetical and authentic densities were found for the hot forged samples which showed that the densities kept on increasing with the addition of Cr. The Cr embellishments were exposed using optical microscopy of varying magnifications. The corrosion properties achieved from the potentiostat showed that the corrosion resistance upsurges more than the other commercially available nickel-aluminum-bronze (NAB) alloys due to the Cr embellishments. The corroded surface was then investigated using scanning electron microscopy (SEM) which disclosed the formation of different κ phases along with an α matrix and other intermetallic phases in the present alloy. Furthermore, hardness tests were taken and these established that the hardness increases with Cr accompaniments. Thus, the present alloy can be endorsed as a novel material (Cu-Al-Ni-Cr) in the propellers of ships in which both hardness and corrosion resistant are obligatory.
The effect of sintering temperature on the porosity and compressive strength of corundum
Authors: Bendaoudi Seif-Eddine , Bounazef Mokhtar , Djeffal Ali
Published: August 2018

Porous corundum ceramic samples were sintered at various temperatures in the range of 1350–1550°C. The effect of the sintering temperature on the porosity rate and compressive strength of corundum samples were investigated. The porosity rates were of the order of 3.3–38% and the high-density sample was obtained at a relatively high temperature. However, an increase of compressive strength by more than 6 times was observed with the sintering temperature rise. The Young’s modulus increased remarkably from 40.49 to 302.15 GPa, which is related to the corresponding decrease of porosity rate.
Travelling-Wave Solutions for Wave Equations with Two Exponential Nonlinearities
Authors: Mancas Stefan C. , Rosu Haret C. , Pérez-Maldonado Maximino
Published: August 2018

We use a simple method that leads to the integrals involved in obtaining the travelling-wave solutions of wave equations with one and two exponential nonlinearities. When the constant term in the integrand is zero, implicit solutions in terms of hypergeometric functions are obtained, while when that term is nonzero, all the basic travelling-wave solutions of Liouville, Tzitzéica, and their variants, as as well sine/sinh-Gordon equations with important applications in the phenomenology of nonlinear physics and dynamical systems are found through a detailed study of the corresponding elliptic equations.
Effects of 6 Weeks of Different High-Intensity Interval and Moderate Continuous Training on Aerobic and Anaerobic Performance
Authors: Cavar Mile , Marsic Toso , Corluka Marin , Culjak Zoran , Cerkez Zovko Ivana , Müller Alex , Tschakert Gerhard , Hofmann Peter
Published: August 2018

Cavar, M, Marsic, T, Corluka, M, Culjak, Z, Cerkez Zovko, I, Müller, A, Tschakert, G, and Hofmann, P. Effects of 6 weeks of different high-intensity interval and moderate continuous training on aerobic and anaerobic performance. J Strength Cond Res 33(1): 44–56, 2019—To provide practical data, we compared the training effects of 3 different programs, using a shuttle run stimulus, on aerobic and anaerobic performance, measured using the 20-m maximal shuttle run (Beep) test and 300-yd shuttle run, respectively. Forty-five physically trained men, with a mean age of 21.1 ± 1.8 years, participated. The 6-week, 12-session training programs included 2 high-intensity interval training (HIIT) protocols, with either a short (SH) or long (LH) shuttle run interval, and a continuous shuttle run (CON), which was used as a control. The training intensity was based on the maximal shuttle run speed (MASS), measured on the Beep test, to elicit the relevant values of the time to exhaustion (TTE). Short (SH) training was performed at 115–120%(MASS), with a 10-second work to 10-second rest scheme, and the number of repetitions to be completed set to 70% of each participant's maximum (∼15 repetitions). LH training was performed at an intensity of 90–95%(MASS), with the duration set to 70%(TTE) (∼4 minutes). For both SH and LH, 3 sets were completed at each session, with a 2–3 minutes of rest between sets. CON training consisted of continuous shuttle running for 35 minutes at an intensity of 70%(MASS). Both SH and LH yielded a large training effect (p < 0.01), with SH preferentially improving anaerobic performance and LH preferentially improving aerobic performance. No effect of CON training was identified. Our findings indicate that these different training protocols cannot be used interchangeably and that the Beep test is useful in prescribing the intensity and duration of HIIT.
Simplified Apparatus for CRS Consolidation Testing of Soils
Authors: Raheena M. , Sridhar G. , Robinson R. G.
Published: August 2018

This article presents the details of a simplified Constant Rate of Strain (CRS) consolidation apparatus for determining consolidation properties of soils. The apparatus has a loading piston with peripheral O-rings that slides through the consolidation ring. The loading piston has provision for back pressure application. The excess pore water pressure developed during the consolidation test can be measured at the base of the specimen. The apparatus is validated by performing CRS consolidation tests on four types of soil specimens of varying plasticity characteristics and on an undisturbed soil specimen. The results from the proposed apparatus were compared with the results obtained from the consolidation tests using the conventional incremental loading oedometer apparatus and the standard CRS consolidation apparatus. The test results prove that the proposed CRS consolidation apparatus can be conveniently used for determining the consolidation properties of soils.
Three-dimensional Reconstruction and Growth Factor Model for Rock Cracks under Uniaxial Cyclic Loading/Unloading by X-ray CT
Authors: Wang Chunlai , Gao Ansen , Shi Feng , Hou Xiaolin , Ni Pengpeng , Ba Deyang
Published: August 2018

The spatial distribution and propagation of cracks are one of the key factors that can influence the initiation of rock failure. In this investigation, the technique of X-ray computed tomography (CT) scanning was used to survey the pattern of rock cracks during cyclic loading/unloading. The distribution and nonlinear development of rock cracks were explored by three-dimensional (3D) reconstruction for use to quantitatively describe their growth. An entropy model for rock mass and a crack growth factor model were established, which could help to reveal the relation between the crack propagation and the macroscopic destruction. The results showed that all disconnected cracks in two-dimensional (2D) images became connected with each other in 3D images. The fractal dimension of rock cracks was increasing first and then decreasing, which was the result of gradual transformation of rock cracks. The growth rate of cracks was decreased with the increase of the quantity of cracks, which was caused by the retardation. When the quantity of cracks grew to a maximal, the growth rate was reduced to zero.
“An Evil Lurking Behind You”: Drivers, Experiences, and Consequences of HIV–Related Stigma Among Men Who Have Sex With Men With HIV in Manila, Philippines
Authors: Adia Alexander C. , Bermudez Amiel Nazer C. , Callahan Michael W. , Hernandez Laufred I. , Imperial Reynaldo H. , Operario Don
Published: August 2018

The Philippines has a rapidly growing HIV epidemic, with men who have sex with men (MSM) accounting for a majority of known cases. Currently, there is little understanding about MSM's experiences of HIV–related stigma in the Philippines and how they influence behavior and quality of life. Twenty-one interviews with MSM living with HIV and with communitybased organization workers were conducted in Manila from June to August 2017. MSM participants were affected by the intersection of HIV–related stigma and stigma toward homosexuality that are rooted in connotations of morality, “dirtiness,” and sin. We identified specific patterns by which MSM living with HIV experienced enacted, felt, and internalized stigma and discuss implications of stigma for mental health, delays in HIV testing, and avoidance of HIV health services. Findings support the development of public health strategies in the Philippines that address stigma at societal and individual levels to reduce stigma-related harms.
A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors
Authors: Sharma Rohan , Gulia Ravinder , Bhattacharyya Samarjit
Published: August 2018

Group I metabotropic glutamate receptors (mGluRs) function as modulators of neuronal physiology and they have also been implicated in various neuropsychiatric disorders. Trafficking of mGluRs plays important roles in controlling the precise localization of these receptors at specific region of the cell, as well as it regulates the activity of these receptors. Despite this obvious significance, we know very little about the cellular machineries that control the trafficking of these receptors in the CNS. Sorting nexin 1 (SNX1) has been shown to regulate the endosomal sorting of few cell surface receptors either to lysosomes where they are downregulated or back to the cell surface. Using “molecular replacement” approach in hippocampal neurons derived from mice of both sexes, we show here that SNX1 plays critical role in the trafficking of mGluR1, a member of the group I mGluR family. Overexpression of dominant-negative SNX1 or knockdown of endogenous SNX1 resulted in the rapid recycling of the receptor. Importantly, recycling via the rapid recycling route, did not allow the resensitization of the receptors. Our data suggest that both, N-terminal and C-terminal region of SNX1 play critical role in the normal trafficking of the receptor. In addition, we also show here that SNX1 regulates the trafficking of mGluR1 through the interaction with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate), a protein that has been implicated in both signaling and vesicular trafficking. Thus, these studies reveal a mechanistic role of SNX1 in the trafficking of group I mGluRs and its physiological implications.

SIGNIFICANCE STATEMENTGroup I mGluRs are activated by the neurotransmitter glutamate in the CNS, and play various important roles in the brain. Similar to many other receptors, trafficking plays crucial roles in controlling the precise localization as well as activity of these receptors. Despite this obvious significance very little is known about the cellular machineries that control the trafficking of these receptors. We demonstrate here, that SNX1 plays a critical role in the trafficking of mGluR1, a member of the group I mGluR family. SNX1-mediated trafficking is critical for the resensitization of the receptor. SNX1 controls the trafficking of the receptor through the interaction with another protein, Hrs. The results suggest a role for SNX1 in the regulation of group I mGluRs.
Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels
Authors: McPherson Kylie B. , Leff Emily R. , Li Ming-hua , Meurice Claire , Tai Sherrica , Traynor John R. , Ingram Susan L.
Published: August 2018

Regulators of G-protein signaling (RGS) proteins negatively modulate presynaptic μ-opioid receptor inhibition of GABA release in the ventrolateral periaqueductal gray (vlPAG). Paradoxically, we find that G-protein-coupled receptor (GPCR) activation of G-protein-gated inwardly rectifying K+channels (GIRKs) in the vlPAG is reduced in an agonist- and receptor-dependent manner in transgenic knock-in mice of either sex expressing mutant RGS-insensitive Gαo proteins. μ-Opioid receptor agonist activation of GIRK currents was reduced for DAMGO and fentanyl but not for [Met5]-enkephalin acetate salt hydrate (ME) in the RGS-insensitive heterozygous (Het) mice compared with wild-type mice. The GABABagonist baclofen-induced GIRK currents were also reduced in the Het mice. We confirmed the role of Gαo proteins in μ-opioid receptor and GABABreceptor signaling pathways in wild-type mice using myristoylated peptide inhibitors of Gαo1and Gαi1–3. The results using these inhibitors indicate that receptor activation of GIRK channels is dependent on the preference of the agonist-stimulated receptor for Gαo versus that for Gαi. DAMGO and fentanyl-mediated GIRK currents were reduced in the presence of the Gαo1inhibitor, but not the Gαi1–3inhibitors. In contrast, the Gαo1peptide inhibitor did not affect ME activation of GIRK currents, which is consistent with results in the Het mice, but the Gαi1–3inhibitors significantly reduced ME-mediated GIRK currents. Finally, the reduction in GIRK activation in the Het mice plays a role in opioid- and baclofen-mediated spinal antinociception, but not supraspinal antinociception. Thus, our studies indicate that RGS proteins have multiple mechanisms of modulating GPCR signaling that produce negative and positive regulation of signaling depending on the effector.

SIGNIFICANCE STATEMENTRegulators of G-protein signaling (RGS) proteins positively modulate GPCR coupling to GIRKs, and this coupling is critical for opioid- and baclofen-mediated spinal antinociception, whereas μ-opioid receptor-mediated supraspinal antinociception depends on presynaptic inhibition that is negatively regulated by RGS proteins. The identification of these opposite roles for RGS proteins has implications for signaling via other GPCRs.
The Lifespan Trajectory of the Encoding-Retrieval Flip: A Multimodal Examination of Medial Parietal Cortex Contributions to Episodic Memory
Authors: Amlien Inge K. , Sneve Markus H. , Vidal-Piñeiro Didac , Walhovd Kristine B. , Fjell Anders M.
Published: August 2018

The formation of episodic memories is associated with deactivation during encoding and activation during retrieval in the posteromedial cortex (PMC). We hypothesized that the encoding/retrieval (E/R) flip is a critical component of episodic memory across the lifespan because structural and metabolic changes in the PMC coincide with the fine tuning of the episodic memory system in development and the reductions of memory performance in aging. The aims of the present study were, first, to describe lifespan trajectories of PMC encoding and retrieval activity in 270 human participants (167 females) from 6 to 80 years of age. Our second goal was to construct a model for episodic memory development in which contributions from brain activity, cortical thickness (CT), and structural connectivity are accounted for. We found that modulation of neural activity in response to memory encoding and retrieval demands was not fully developed until adolescence and decreased from adulthood through old age. The magnitude of the E/R flip was related to source memory and 55% of the age-related variance in source memory performance during childhood and adolescence could be accounted for by the E/R flip, CT, and mean diffusivity together. However, only CT and the E/R flip provided unique contributions with which to explain memory performance. The results suggest that neural dynamics in the PMC is related to the development of episodic memory during childhood and adolescence. The similar trajectories of the E/R flip and episodic memory emergence and decline through development and aging further suggests that a lifelong relationship exists.

SIGNIFICANCE STATEMENTModulation of neural activity in the posteromedial cortex (PMC) in response to memory encoding/retrieval (E/R) demands (E/R flip) does not reach its peak until adolescence and decreases from adulthood through old age. The magnitude of the E/R flip is related to source memory and 55% of the age-related variance in source memory performance during childhood and adolescence can be accounted for by the E/R flip and brain structure together. The results suggest that neural dynamics in the PMC is related to the development of episodic memory function during childhood and adolescence and the similar trajectories of the E/R flip and episodic memory performance through development and aging suggests that a lifelong relationship exists.
A Functional riboSNitch in the 3′ Untranslated Region ofFKBP5Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain
Authors: Linnstaedt Sarah D. , Riker Kyle D. , Rueckeis Cathleen A. , Kutchko Katrina M. , Lackey Lela , McCarthy Kathleen R. , Tsai Yi-Hsuan , Parker Joel S. , Kurz Michael C. , Hendry Phyllis L. , Lewandowski Christopher , Datner Elizabeth , Pearson Claire , O'Neil Brian , Domeier Robert , Kaushik Sangeeta , Laederach Alain , McLean Samuel A.
Published: August 2018

Previous studies have shown that common variants of the gene coding for FK506-binding protein 51 (FKBP5), a critical regulator of glucocorticoid sensitivity, affect vulnerability to stress-related disorders. In a previous report,FKBP5rs1360780 was identified as a functional variant because of its effect on gene methylation. Here we report evidence for a novel functionalFKBP5allele, rs3800373. This study assessed the association between rs3800373 and post-traumatic chronic pain in 1607 women and men from two ethnically diverse human cohorts. The molecular mechanism through which rs3800373 affects adverse outcomes was established viain silico,in vivo, andin vitroanalyses. The rs3800373 minor allele predicted worse adverse outcomes after trauma exposure, such that individuals with the minor (risk) allele developed more severe post-traumatic chronic musculoskeletal pain. Among these individuals, peritraumatic circulatingFKBP5expression levels increased as cortisol and glucocorticoid receptor (NR3C1) mRNA levels increased, consistent with increased glucocorticoid resistance. Bioinformatic,in vitro, and mutational analyses indicate that the rs3800373 minor allele reduces the binding of a stress- and pain-associated microRNA, miR-320a, toFKBP5via altering theFKBP5mRNA 3′UTR secondary structure (i.e., is a riboSNitch). This results in relatively greaterFKBP5translation, unchecked by miR-320a. Overall, these results identify an important gene–miRNA interaction influencing chronic pain risk in vulnerable individuals and suggest that exogenous methods to achieve targeted reduction in poststressFKBP5mRNA expression may constitute useful therapeutic strategies.

SIGNIFICANCE STATEMENTFKBP5is a critical regulator of the stress response. Previous studies have shown that dysregulation of the expression of this gene plays a role in the pathogenesis of chronic pain development as well as a number of comorbid neuropsychiatric disorders. In the current study, we identified a functional allele (rs3800373) in the 3′UTR ofFKBP5that influences vulnerability to chronic post-traumatic pain in two ethnic cohorts. Using multiple complementary experimental approaches, we show that theFKBP5rs3800373 minor allele alters the secondary structure ofFKBP5mRNA, decreasing the binding of a stress- and pain-associated microRNA, miR-320a. This results in relatively greaterFKBP5translation, unchecked by miR-320a, increasing glucocorticoid resistance and increasing vulnerability to post-traumatic pain.
Credible Confidence: A Pragmatic View on the Frequentist vs Bayesian Debate
Authors: Albers Casper J. , Kiers Henk A. L. , van Ravenzwaaij Don
Published: August 2018

The debate between Bayesians and frequentist statisticians has been going on for decades. Whilst there are fundamental theoretical and philosophical differences between both schools of thought, we argue that in two most common situations the practical differences are negligible when off-the-shelf Bayesian analysis (i.e., using ‘objective’ priors) is used. We emphasize this reasoning by focusing on interval estimates: confidence intervals and credible intervals. We show that this is the case for the most common empirical situations in the social sciences, the estimation of a proportion of a binomial distribution and the estimation of the mean of a unimodal distribution. Numerical differences between both approaches are small, sometimes even smaller than those between two competing frequentist or two competing Bayesian approaches. We outline the ramifications of this for scientific practice.
Robert Stam, leitor de A hora da estrela
Authors: Mousinho Magalhães Luiz Antonio
Published: August 2018

Em A literatura através do cinema, Robert Stam aborda a adaptação da novela A hora da estrela, de Clarice Lispector, para o cinema, realizada pela cineasta Suzana Amaral. No texto, o autor indica uma questão crítica recorrente no confronto entre filme e obra literária, que é a exclusão do narrador-personagem Rodrigo S.M. da obra fílmica e de elementos de reflexividade relacionados ao narrador, bem como a relação dessa supressão com as tensões entre cinema narrativo e modernismo artístico. Buscaremos acompanhar o debate teórico e crítico de Stam, um dos mais relevantes teóricos contemporâneos, procurando suplementá-lo na abordagem das duas obras. Tomaremos por apoio a narratologia, com ênfase para categorias como narrador e personagem. Em termos de resultados obtidos, atestamos na leitura de Stam o respeito pela obra cinematográfica percebida em sua autonomia discursiva, bem como certa decepção pelo filme ter aberto mão das experiências de linguagem contidas no texto-fonte.
Tele-visões em interfaces contemporâneas
Authors: Kilpp Suzana
Published: August 2018

O artigo objetiva discutir a dispersão de conteúdos televisivos pela internet e por dispositivos móveis como equivalente à dispersão da televisão nessas mídias. Para tanto analisa, sob a metodologia das molduras, algumas imagens médias de interfaces gráficas nas quais esses conteúdos são acessados on-line no computador e em dispositivos móveis. Adota como referência teórica principal a fenomenologia bergsoniana, e entende que a questão central para o discernimento gira em torno da compreensão do fenômeno ou coisa chamada interface.
A reportagem autorreflexiva
Authors: Serelle Marcio
Published: August 2018

Este artigo objetiva analisar reportagens que, ao modo de um documentário reflexivo, são autocríticas em relação a seu campo de ação e à ética da representação do outro na narrativa jornalística. Essas reportagens emergem, nos casos estudados, da relação entre texto e paratexto, quando da publicação em livro. As narrativas são abordadas, neste trabalho, por meio do cotejo com a categoria do documentário reflexivo, em Bill Nichols, e do estudo do paratexto, em Gerárd Genette. A partir dessas noções, examina-se o discurso autorreflexivo em reportagens das brasileiras Fabiana Moraes e Eliane Brum e da bielorrussa Svetlana Aleksiévitch. Os resultados desta pesquisa apontam para a recorrência de relatos que assumem a impossibilidade de narrar o outro e reivindicam, na revisão e crítica que fazem das práticas jornalísticas, a ruptura com a chamada “rede técnica” do campo.
Embatimentos poéticos no filme "Praia do futuro"
Authors: Garcia Wilton
Published: August 2018

Este texto expõe uma leitura crítica – em formato de ensaio – sobre o filme Praia do futuro (Karim Aïnouz, 2014), ao relacionar cinema e diversidade cultural/sexual no Brasil atualmente. Não se trata de uma análise fílmica, mas sim ter a referida película como exemplificação nesse contexto. Para desenvolver esta leitura, o percurso metodológico divide-se em observação, descrição e discussão sobre a referida película. Da comunicação às práticas socioculturais, as categorias discursivas experiência, imagem, performance e subjetividade, de modo estratégico, enunciam os estudos contemporâneos. Disso, deriva uma pergunta: como propor uma política do afeto no cinema contemporâneo que acompanhe a diversidade cultural/sexual no país e no mundo? A partir de uma política do afeto, os resultados incorporam um movimento entre corpo, gênero, identidade sexual nessa discussão a respeito do homoerotismo no cinema brasileiro atual.
Entre regulações e táticas: músicas nas ruas da cidade do Rio de Janeiro.
Authors: Reia Jhessica , Herschmann Micael , Fernandes Cíntia Sanmartin
Published: August 2018

Algumas práticas culturais que ocorrem nos espaços públicos urbanos evidenciam disputas pelo direito à cidade, justamente por apontarem para dinâmicas de poder e resistências que ocorrem nas cidades contemporâneas. Adotando uma perspectiva que conjuga comunicação, cidade e música, este trabalho tem como objetivo central analisar as dinâmicas entre regulação e táticas da música nas ruas do Rio de Janeiro em um contexto de megaeventos e transição política e econômica. A análise construída aqui busca compreender os processos de ocupação e mobilização política que gravitam em torno da música tocada nas ruas cariocas. Estas reflexões tomaram como referência entrevistas que foram realizadas com artistas, produtores culturais, lideranças locais e autoridades, assim como observação participante que ocorreram entre 2013 e 2017.
Prevenção universal e promoção de saúde em grupo de crianças a partir do Método Friends
Authors: Pavoski Giulia Tatiana Tkaczyk , Toni Caroline Guisantes de Salvo , Batista Ana Priscila , Ignachewski Cynthia Lais
Published: August 2018

Os transtornos de ansiedade e depressão têm aumentado de forma considerável na população, sendo que seus sintomas tendem a manifestar-se já na infância. Intervenções para esses transtornos podem ser realizadas através do desenvolvimento de habilidades socioemocionais e de resiliência. O Método Friends é um programa baseado em evidências que visa desenvolver essas habilidades. Nesse contexto, esta pesquisa consistiu em uma avaliação da eficácia do Método Friends em um grupo de crianças. A amostra consistiu de 10 crianças, de ambos os sexos, com idades entre 6 e 7 anos. Estas participaram do Método em uma Clínica-Escola de uma cidade do Interior do Paraná. Foi utilizado como instrumento de avalição o CBCL, aplicado em três momentos: pré-teste, pós-teste e follow up. Foram verificadas diferenças estatisticamente significativas nos três momentos em escalas relacionadas a competências sociais, escala de internalização e de externalização, ansiedade, depressão, retraimento e comportamento agressivo. De forma geral observou-se a eficácia do Método.
Sintomas depressivos, de ansiedade e de estresse em habitantes de munícipio realocado por barragem
Authors: Pozzebon Franciele Luísa , Ferreira Vinícius Renato Thomé
Published: August 2018

O aumento da necessidade de energia elétrica faz com que a instalação de usinas hidrelétricas seja um investimento importante; entretanto, os impactos ambientais e humanos decorrentes da instalação de barragens precisam ser apropriadamente avaliados. Buscou-se investigar a prevalência de sintomas depressivos, de ansiedade e de estresse de uma população que passou pelo processo de realocação devido à construção de uma barragem para usina hidrelétrica (n = 50) em comparação com um município onde não houve este processo (n = 50). Foi identificado que, vinte anos após a instalação da barragem e realocação do município, os escores de sintomas depressivos, de ansiedade e de estresse estão na faixa da população não clínica, e foram mais elevados no município de comparação do que no município onde a barragem foi instalada. Estudos sobre a instalação de barragens e realocação humana precisam considerar, além dos impactos ambientais, seus reflexos sobre a saúde mental das pessoas.
Body image perception and sense of agency: notes from the alien hand experiment
Authors: Pinhatti Marcelle Matiazo , Castro Thiago Gomes de , Gomes William Barbosa
Published: August 2018

Body image perception comprises stable and dynamic representational features. Here, we examined whether a stable body image (BI) measure correlates to a dynamic sense of agency (SoA) score. Moreover, we tested whether differential BI perception scores predicts SoA performance under sensory conflict conditions. A total of 21 university students (age M=25.9, SD=9.29) completed the Brazilian version of the Silhouette Figures Scale (SFS) and participated in The Alien Hand Experiment (TAHE). TAHE is a task that manipulates participants’ hand movement SoA. A Bayesian correlation matrix revealed substantial negative correlation probability between BI perception and SoA confidence in accuracy responses, specifically in experimental conditions where agency was manipulated. Based on the SFS scores, participants were divided into groups with and without evidences of BI distortion. Bayesian Independent Samples T-Tests evidenced substantial differential probability between groups. Analyzes confirmed lower SoA confidence among subjects with BI distortion greater than ±3 kg/m².
Comparison of the effect of game based on educational method and traditional approach on the performance of selected basketball skills
Authors: Ghanati P. , MohammadZadeh H.
Published: August 2018

Background and Study Aim: The purpose of this study was to investigate the effect of the game based on educational method and traditional approach on the performance of selected basketball skills. Materials : The type of research was semi-experimental one. Participants included 30 adolescent girls who were divided into two groups based on the game-based practice (15) and traditional training (15) build on the pre-test scores. Both groups performed the intervention program for 8 weeks and each week for three 60-minute sessions. Then, a post-test was performed and the data were analyzed using SPSS 21 software at a significance level of 0.05. Results: The results showed that both educational method and traditional approach groups had a significant improvement in basketball performance; there was no improvement in basketball dribbling performance in both groups. However, in the performance test, game based on educational method group had a significant improvement compared to the traditional practice one. Conclusion: The results suggest that using a game-based educational method can significantly increase the important factors of basketball performance in youth, which can move into more complex situations.