bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal, reciprocal relationships between family management and antisocial peer associations
Authors: Mehus Christopher J. , Forster Myriam , Chan Gary , Hemphill Sheryl A. , Toumbourou John W. , McMorris Barbara J.
Published: August 2018

Introduction

Poor family management and antisocial peer associations are related risk factors for negative outcomes such as adolescent substance misuse and conduct disorders. The relationship between family management and antisocial peer associations is complex. The purpose of this study was to test the reciprocal relationships between youth‐reports of poor family management and antisocial peer associations over multiple time‐points.

Methods

We used four data points (5th‐11th grade) from the Australian arm of the longitudinal International Youth Development Study (IYDS) to test a random‐intercepts cross‐lagged path model (N = 922).

Results

The model fit the data well with path estimates showing that poor family management predicted greater antisocial peer associations at the next wave but not the reverse. A second model included a third autoregressive path to control for youth's own antisocial behavior; the direction of the relationships between poor family management and antisocial peer associations did not change.

Conclusions

These results indicate that across adolescence poor family management predicts greater antisocial peer association, which provides evidence that family‐focused interventions are an important prevention strategy even in adolescence.
Practice Patterns Among Korean Urologists for Glans Penis Augmentation Using Hyaluronic Acid Filler in the Management of Premature Ejaculation
Authors: Jeong Hyeong Guk , Ahn Sun Tae , Kim Jong Wook , Seo Kyung Keun , Lee Dong Soo , Uh Hong Sun , Kim Je Jong , Moon Du Geon
Published: August 2018

Introduction

Glans penis augmentation (GPA) using hyaluronic acid (HA) gel has been developed for treating premature ejaculation (PE) with penile hypersensitivity. The injected HA filler creates a barrier that reduces the tactile stimuli to the hypersensitive dorsal nerve. Although the HA filler is biodegradable and is believed to not cause permanent loss of sexual function, the current International Society for Sexual Medicine guideline for PE does not recommend this procedure owing to concerns regarding sexual dysfunction.

Aim

To investigate the practice patterns for GPA using HA filler among Korean urologists, and to identify whether urologist experienced patient reports of sexual dysfunction post-treatment.

Methods

Between March 2016 and July 2016, a specially designed questionnaire was mailed to 86 selected Korean urologists who had used injectable materials to treat PE.

Main Outcome Measures

The prevalence and awareness of sexual dysfunction after GPA using HA filler were evaluated.

Results

Overall, 56 urologists completed the survey (response rate: 69.2%), of which 36 (64.3%) had performed GPA using HA filler. They reported having performed a combined total of 4,344 such GPA procedures. Most urologists (72.7%) performed GPA using HA filler in patients who benefit from topical anesthetics. Patients with a history of failed pharmacotherapy (59.1%) and selective dorsal nerve neurotomy (45.5%) were selected for GPA using HA filler. The respondents (44.4%) encountered overall 206 (4.7%) cases of patients reports of recurrence of PE. Interestingly, only 36 (0.8%) cases of glans pain or paresthesia and no cases of erectile dysfunction post-treatment were reported.

Conclusion

Korean urologists performed GPA using HA filler when pharmacotherapy failed or if there was a response to topical treatment. Paresthesia and hypoesthesia after GPA using HA filler are rare, and no cases of erectile dysfunction were encountered by Korean urologists.
Diffusiophoresis of a charged drop
Authors: Yang Fan , Shin Sangwoo , Stone Howard A.
Published: August 2018

Diffusiophoresis describes the motion of colloids in an electrolyte or non-electrolyte solution where there is a concentration gradient. While most of the studies of diffusiophoresis focus on the motion of solid particles, soft objects such as drops and bubbles are also known to experience diffusiophoresis. Here, we investigate the diffusiophoresis of charged drops in an electrolyte solution both analytically and experimentally. The drop is assumed to remain spherical. An analytical solution of the diffusiophoretic velocity of drops is obtained by perturbation methods. We find that the flow inside the drop is driven by the tangential electric stress at the interface and it directly influences the diffusiophoretic speed of the drop. Using charged oil droplets, we measure the drop speed under solute concentration gradients and find good agreement with the analytical solution. Our findings have potential applications for oil recovery and drug delivery.
Material Shear Strength Assessment of AU/20SN Interconnection for High Temperature Applications
Authors: Liao L. L. , Chiang K. N.
Published: August 2018

When a power module is under a continuous electrical load, a temperature effect is induced by the current load in the module configuration. The joint material therefore has long-term temperature and mechanical loadings under supplied power. A long-term temperature load can change the material and mechanical properties, including voiding, cracking, creeping and fracturing. Au/20Sn eutectic alloy, a highly temperature resistant material, is typically used for electric interconnections in high-power modules. The Au/20Sn is converted into AuSn and an Au5Sn intermetallic compound (IMC) by solid liquid inter-diffusion (SLID) bonding to form joints with high melting points. In this study, a test vehicle based on an actual power module was designed and fabricated to investigate and understand the material properties and mechanical behavior of Au/20Sn solder under a temperature load. The joint microstructure exhibited variation under different thermal treatment conditions such as temperature and load durations. The shear strength test was conducted to examine the mechanical strength of the joints under different thermal load conditions. The failure mode of the joint was further determined using fracture morphology after the shear test. Finally, the shear strength of Au/20Sn was identified to investigate the high temperature resistance of joints under different temperatures. The mechanical strengths of joints under different temperature loads are expressions of different mechanical characteristics and can be used to determine reliability at an intended high application temperature.
A New Graphitization System for Radiocarbon Dating with AMS in the Dendrochronological Laboratory at AGH-UST Kraków
Authors: Krąpiec Marek , Rakowski Andrzej , Huels Matthias , Wiktorowski Damian , Hamann Christian
Published: August 2018

A new vacuum system for the preparation of graphite samples for radiocarbon (14C) measurement using an accelerator mass spectrometer (AMS) was constructed at the Dendrochronological Laboratory in AGH-UST Kraków. The central part of the system is a manual vacuum line for the production of graphite from carbon dioxide for subsequent AMS measurements. The graphitization system can handle up to five samples simultaneously, and the process lasts for approximately 1 hour. The graphitization line was built to support the preparation of wood samples for a project dedicated to dating a subfossil tree from the Younger Dryas period. For this purpose, the chemical preparation procedure for wood samples was optimized to obtain more reliable results. This includes the extraction of α-cellulose to increase the precision of the age determination. The performance of the system was tested with NIST OxII, IAEA standards (IAEA C3, C5, C6, and C8), and background samples. The results of the 13 samples of subfossil wood were tested and are presented. The methodology gives good reproducibility of results obtained for the samples prepared using this system.
Association of dietary sodium:potassium ratio with the metabolic syndrome in Chinese adults
Authors: Li Xiaocheng , Guo Baofu , Jin Di , Wang Yanli , Jiang Yun , Zhu Baichun , Chen Yang , Ma Liankai , Zhou Han , Xie Guoxiang
Published: August 2018

Several epidemiological studies have investigated that Na or K intakes might be associated with the metabolic syndrome (MetS). However, little evidence has evaluated the association between Na:K ratio and the MetS. In this study, we assessed the association between the dietary Na:K ratio and the MetS. The cross-sectional study was conducted among adults aged 18 years and older in Nanjing, using a multi-stage random sampling method, which resulted in a sample size of 1993 participants. Dietary Na and K intakes were assessed by 3 consecutive days of dietary recollection combined with condiments weighing method. Health-related data were obtained by standardised questionnaires, as well as physical examinations and laboratory assessments. The prevalence rate of the MetS was 36·5 % (728/1993). After adjusting for various lifestyle and dietary factors of the MetS, participants in the highest quartile of dietary Na:K ratio were at a higher risk of developing MetS (OR=1·602; 95 % CI 1·090, 2·353) compared with those in the lowest quartile. Each 1-sd increase in dietary Na:K ratio was associated with a higher risk of prevalent MetS (OR=1·166; 95 % CI: 1·018, 1·336). Among the components of the MetS, dietary Na:K ratio was positively associated with high blood pressure (quartile 3 v. quartile 1: OR=1·656; 95 % CI 1·228, 2·256) and hypertriacylglycerolaemia (quartile 4 v. quartile1: OR=1·305; 95 % CI 1·029, 1·655) in multivariate analysis. These results revealed that higher dietary Na:K ratio significantly increased the risk of the MetS in Chinese adults. Further studies are needed to verify this association.
The effects of nasal irrigation with various solutions after endoscopic sinus surgery: systematic review and meta-analysis
Authors: Chen X Z , Feng S Y , Chang L H , Lai X P , Chen X H , Li Xia , Zhang G H
Published: August 2018

Background

Nasal irrigation is commonly performed in patients with chronic rhinosinusitis after functional endoscopic sinus surgery. This study systematically assessed the clinical efficacy of nasal irrigation from the medical literature.

Methods

The PubMed, Embase and Cochrane Central Register of Controlled Trials databases were searched using a comprehensive strategy, limited to English-language articles, published from October 1971 to March 2017, and comprising human subjects.

Results

A total of 824 trials were identified, 5 of which, involving 331 participants, were included in this systematic review. After selection, only three trials were eligible for inclusion in a meta-analysis. Nasal irrigation using normal saline and various solutions was found to be effective in reducing symptom scores and endoscopic scores for chronic rhinosinusitis patients after functional endoscopic sinus surgery. Comparison of outcome measures, such as eosinophil count reduction, revealed that various solutions are more effective than normal saline alone; however, no statistical significance was found in terms of reduced symptom or endoscopic scores.

Conclusion

Based on the current limited evidence, nasal irrigation is an effective therapy for chronic rhinosinusitis patients after functional endoscopic sinus surgery. However, when comparing various solutions with normal saline, no significant difference was found in symptom scores or endoscopic scores.
Acquisition of weak syllables in tonal languages: acoustic evidence from neutral tone in Mandarin Chinese
Authors: TANG Ping , YUEN Ivan , XU RATTANASONE Nan , GAO Liqun , DEMUTH Katherine
Published: August 2018

Weak syllables in Germanic and Romance languages have been reported to be challenging for young children, with syllable omission and/or incomplete reduction persisting till age five. In Mandarin Chinese, neutral tone (T0) involves a weak syllable with varied pitch realizations across (preceding) tonal contexts and short duration. The present study examined how and when T0 was acquired by 108 Beijing Mandarin-speaking children (3–5 years) relative to 33 adult controls. Lexicalized (familiar) and non-lexicalized (unfamiliar) T0 words were elicited in different preceding tonal contexts. Unlike previous reports, the present study revealed that children as young as three years have already developed a phonological category for T0, exhibiting contextually conditioned tonal realizations of T0 for both familiar and unfamiliar items. However, mastery of adult-like pitch and duration implementation of T0 is a protracted process not completed until age five. The implications for the acquisition of weak syllables more generally are discussed.
Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence
Authors: Barker Edward D. , Cecil Charlotte A. M. , Walton Esther , Houtepen Lotte C. , O'Connor Thomas G. , Danese Andrea , Jaffee Sara R. , Jensen Sarah K. G. , Pariante Carmine , McArdle Wendy , Gaunt Tom R. , Relton Caroline L. , Roberts Susanna
Published: August 2018

In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.
Prenatal stress and the developing brain: Risks for neurodevelopmental disorders
Authors: Van den Bergh Bea R. H. , Dahnke Robert , Mennes Maarten
Published: August 2018

The prenatal period is increasingly considered as a crucial target for the primary prevention of neurodevelopmental and psychiatric disorders. Understanding their pathophysiological mechanisms remains a great challenge. Our review reveals new insights from prenatal brain development research, involving (epi)genetic research, neuroscience, recent imaging techniques, physical modeling, and computational simulation studies. Studies examining the effect of prenatal exposure to maternal distress on offspring brain development, using brain imaging techniques, reveal effects at birth and up into adulthood. Structural and functional changes are observed in several brain regions including the prefrontal, parietal, and temporal lobes, as well as the cerebellum, hippocampus, and amygdala. Furthermore, alterations are seen in functional connectivity of amygdalar–thalamus networks and in intrinsic brain networks, including default mode and attentional networks. The observed changes underlie offspring behavioral, cognitive, emotional development, and susceptibility to neurodevelopmental and psychiatric disorders. It is concluded that used brain measures have not yet been validated with regard to sensitivity, specificity, accuracy, or robustness in predicting neurodevelopmental and psychiatric disorders. Therefore, more prospective long-term longitudinal follow-up studies starting early in pregnancy should be carried out, in order to examine brain developmental measures as mediators in mediating the link between prenatal stress and offspring behavioral, cognitive, and emotional problems and susceptibility for disorders.
Prenatal programming of postnatal plasticity revisited—And extended
Authors: Hartman Sarah , Belsky Jay
Published: August 2018

Two sets of evidence reviewed herein, one indicating that prenatal stress is associated with elevated behavioral and physiological dysregulation and the other that such phenotypic functioning is itself associated with heightened susceptibility to positive and negative environmental influences postnatally, raises the intriguing hypothesis first advanced by Pluess and Belsky (2011) that prenatal stress fosters, promotes, or “programs” postnatal developmental plasticity. Here we review further evidence consistent with this proposition, including new experimental research systematically manipulating both prenatal stress and postnatal rearing. Collectively this work would seem to explain why prenatal stress has so consistently been linked to problematic development: stresses encountered prenatally are likely to continue postnatally, thereby adversely affecting the development of children programmed (by prenatal stress) to be especially susceptible to environmental effects. Less investigated are the potential benefits prenatal stress may promote, due to increased plasticity, when the postnatal environment proves to be favorable. Future directions of research pertaining to potential mechanisms instantiating postnatal plasticity and moderators of such prenatal-programming effects are outlined.
The early care environment and DNA methylome variation in childhood
Authors: Garg Elika , Chen Li , Nguyen Thao T. T. , Pokhvisneva Irina , Chen Lawrence M. , Unternaehrer Eva , MacIsaac Julia L. , McEwen Lisa M. , Mah Sarah M. , Gaudreau Helene , Levitan Robert , Moss Ellen , Sokolowski Marla B. , Kennedy James L. , Steiner Meir S. , Meaney Michael J. , Holbrook Joanna D. , Silveira Patricia P. , Karnani Neerja , Kobor Michael S. , O'Donnell Kieran J. ,   Mavan Study Team
Published: August 2018

Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99,SD= 1.33 years,n= 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs.
Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised
Authors: Gustafsson Hanna C. , Goodman Sherryl H. , Feng Tianshu , Choi Jean , Lee Seonjoo , Newport D. Jeffrey , Knight Bettina , Pingeton Blaire , Stowe Zachary N. , Monk Catherine
Published: August 2018

Psychotropic medication use and psychiatric symptoms during pregnancy each are associated with adverse neurodevelopmental outcomes in offspring. Commonly, studies considering medication effects do not adequately assess symptoms, nor evaluate children when the effects are believed to occur, the fetal period. This study examined maternal serotonin reuptake inhibitor and polypharmacy use in relation to serial assessments of five indices of fetal neurobehavior and Bayley Scales of Infant Development at 12 months in N = 161 socioeconomically advantaged, non-Hispanic White women with a shared risk phenotype, diagnosed major depressive disorder. On average fetuses showed the expected development over gestation. In contrast, infant average Bayley psychomotor and mental development scores were low (M = 84.10 and M = 89.92, range of normal limits 85–114) with rates of delay more than 2–3 times what would be expected based on this measure's normative data. Controlling for prenatal and postnatal depressive symptoms, prenatal medication effects on neurobehavioral development were largely undetected in the fetus and infant. Mental health care directed primarily at symptoms may not address the additional psychosocial needs of women parenting infants. Speculatively, prenatal serotonin reuptake inhibitor exposure may act as a plasticity rather than risk factor, potentially enhancing receptivity to a nonoptimal postnatal environment in some mother–infant dyads.
The influence of prenatal experience on behavioral and social development: The benefits and limitations of an animal model
Authors: Lickliter Robert
Published: August 2018

Prenatal experience is both a formative and a regulatory force in the process of development. As a result, birth is not an adequate starting point for explanations of behavioral development. However, surprisingly little is currently known regarding the role of prenatal experience in the emergence and facilitation of perceptual, cognitive, or social development. Our lack of knowledge in this area is due in part to the very restricted experimental manipulations possible with human fetuses. A comparative approach utilizing animal models provides an essential step in addressing this gap in our knowledge and providing testable predictions for studies with human fetuses, infants, and children. Further, animal-based comparative research serves to minimize the amount of exploratory research undertaken with human subjects and hone in on issues and research directions worthy of further research investment. In this article, I review selected animal-based research exploring how developmental influences during the prenatal period can guide and constrain subsequent behavioral and social development. I then discuss the importance of linking the prenatal environment to postnatal outcomes in terms of how psychologists conceptualize “innate” biases, preferences, and skills in the study of human development.
An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior
Authors: Conradt Elisabeth , Adkins Daniel E. , Crowell Sheila E. , Monk Catherine , Kobor Michael S.
Published: August 2018

Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior.
Prenatal neural origins of infant motor development: Associations between fetal brain and infant motor development
Authors: Thomason Moriah E. , Hect Jasmine , Waller Rebecca , Manning Janessa H. , Stacks Ann M. , Beeghly Marjorie , Boeve Jordan L. , Wong Kristyn , van den Heuvel Marion I. , Hernandez-Andrade Edgar , Hassan Sonia S. , Romero Roberto
Published: August 2018

Functional circuits of the human brain emerge and change dramatically over the second half of gestation. It is possible that variation in neural functional system connectivity in utero predicts individual differences in infant behavioral development, but this possibility has yet to be examined. The current study examines the association between fetal sensorimotor brain system functional connectivity and infant postnatal motor ability. Resting-state functional connectivity data was obtained in 96 healthy human fetuses during the second and third trimesters of pregnancy. Infant motor ability was measured 7 months after birth using the Bayley Scales of Infant Development. Increased connectivity between the emerging motor network and regions of the prefrontal cortex, temporal lobes, posterior cingulate, and supplementary motor regions was observed in infants that showed more mature motor functions. In addition, females demonstrated stronger fetal-brain to infant-behavior associations. These observations extend prior longitudinal research back into prenatal brain development and raise exciting new ideas about the advent of risk and the ontogeny of early sex differences.
Climate risk and food availability in Guatemala
Authors: Vargas Renato , Cabrera Maynor , Cicowiez Martin , Escobar Pamela , Hernández Violeta , Cabrera Javier , Guzmán Vivian
Published: August 2018

In this paper, we use a computable general equilibrium model to simulate the effects of drought and a decrease in agricultural productivity caused by climate change in Guatemala. A reduction in agricultural productivity would mean a considerable drop in crop and livestock production, and the resulting higher prices and lower household income would mean a significant reduction in the consumption of agricultural goods and food. The most negative effects of a drought would be concentrated in agriculture, given its intensive use of water. Because agricultural production is essential to ensuring food availability, these results suggest that Guatemala needs a proper water-distribution regulatory framework.
Antimicrobial-based dry cow therapy approaches for cure and prevention of intramammary infections: a protocol for a systematic review and meta-analysis
Authors: Afifi Mohamed , Kabera Fidèle , Stryhn Henrik , Roy Jean-Philippe , Heider Luke C. , Godden Sandra , Montelpare William , Sanchez Javier , Dufour Simon
Published: August 2018

In dairy herds, application of antimicrobials at drying-off is a common mastitis control measure. This article describes a protocol for systematic review and meta-analysis to address three crucial points regarding antimicrobial usage at drying-off: (1) comparative efficacy of antimicrobials used for preventing new and eliminating existing intramammary infections (IMI); (2) comparison of selective and blanket dry cow therapy approaches in preventing new and eliminating existing IMI; and (3) assessment of the extra prevention against new IMI that can be gained from using antimicrobial-teat sealant combinations versus antimicrobials alone. Five PICO (Population, Intervention, Comparator, Outcome) questions were formulated to cover the three objectives of the review. Medline, CAB Abstracts, Web of Science, and conference proceedings will be searched along with iterative screening of references. Articles will be eligible if: (1) published after 1966; (2) written in English or French; and (3) reporting field clinical trials and observational studies, conducted on dairy cows at drying-off, with at least one antimicrobial-treated group and one IMI-related outcome. Authors will independently assess the relevance of titles and abstracts, extract data, and assess bias and the overall quality of evidence. Results will be synthesized and analyzed using pairwise and network meta-analysis. The proposed study will significantly update previously conducted reviews.
The National Health Service (NHS) in ‘crisis’: the role played by a shift from horizontal to vertical principles of equity
Authors: Asthana Sheena , Gibson Alex
Published: August 2018

Explanations of the state of ‘crisis’ in the English National Health Service (NHS) generally focus on the overall level of health care funding rather than the way in which funding is distributed. Describing systematic patterns in the way different areas are experiencing crisis, this paper suggests that NHS organisations in older, rural and particularly coastal areas are more likely to be ‘failing’ and that this is due to the historic underfunding of such areas. This partly reflects methodological and technical shortcomings in NHS resource allocation formulae. It is also the outcome of a philosophical shift from horizontal (equal access for equal needs) to vertical (unequal access to equalise health outcomes) principles of equity. Insofar as health inequalities are determined by factors well beyond health care, we argue that this is an ineffective approach to addressing health inequalities. Moreover, it sacrifices equity in access to health care by failing to adequately fund the health care needs of older populations. The prioritisation of vertical over horizontal equity also conflicts with public perspectives on the NHS. Against this background, we ask whether the time has come to reassert the moral and philosophical case for the principle of equal access for equal health care need.
“S/he’s Taken”
Authors: Hart William , Tortoriello Gregory K. , Richardson Kyle , Adams John
Published: August 2018

Abstract. Narcissists’ threat reactivity can be differentiated into cognitive, emotional, and tactical-behavioral responses, and these dimensions of reactivity are presumed to vary as a function of grandiose and vulnerable narcissism. The present research applied this conceptual model to situations involving a relationship threat from a rival. A college sample completed measures of vulnerable narcissism, pathological and non-pathological measures of grandiose narcissism, and then indicated anticipated cognitive, emotional, and tactical responses to situations involving high and low levels of rival threat. All narcissism forms generally converged on similar tactical responses – specifically, enhanced coercive and mate-value-enhancement tactics. Yet, both pathological and non-pathological expressions of grandiose narcissism diverged from vulnerable narcissism on cognitive and emotional outcomes, such that only vulnerable narcissism related to enhanced worrying and negative emotionality. Furthermore, all narcissism forms were more strongly related to coercive tactics against the rival following high (vs. low) rival threat.
Something’s Going on Here
Authors: Hart Joshua , Graether Molly
Published: August 2018

Abstract. Research on individual-difference factors predicting belief in conspiracy theories has proceeded along several independent lines that converge on a profile of conspiracy believers as individuals who are relatively untrusting, ideologically eccentric, concerned about personal safety, and prone to perceiving agency in actions and profundity in bullshit. The present research represents the first attempt at an integrative approach to testing the independent contributions of these diverse factors to conspiratorial thinking. Two studies (N = 1,253) found that schizotypy, dangerous-world beliefs, and bullshit receptivity independently and additively predict endorsement of generic (i.e., nonpartisan) conspiracy beliefs. Results suggest that “hyperactive” agency detection and political orientation (and related variables) might also play a role. The studies found no effects of situational threats (mortality salience or a sense of powerlessness) – though it remains to be seen whether real-world instantiations of situational threats might move some people to seek refuge in conspiratorial ideation.
Craton Destruction 1: Cratonic Keel Delamination Along a Weak Midlithospheric Discontinuity Layer
Authors: Liu Liang , Morgan Jason P. , Xu Yigang , Menzies Martin
Published: August 2018

Cratons are generally observed to retain thick (>180 km) conductive keels for billions of years. However, some cratons have undergone keel removal, with well‐documented examples being the eastern North China Craton (NCC) and the Wyoming Craton (WC). These keelless subregions appear to have kept a lithospheric bottom at ~80–100‐km depths. This is also the depth range where modern cratons, including the remaining portions of the NCC and the WC, have seismically visible midlithospheric discontinuity layers (MLDLs). MLDLs are proposed to be regions of preferential accumulation of metasomatic minerals and/or anomalously wet (>1,000 ppm) peridotites, both of which would lead to a relatively weak rheology. We propose that the cratonic keels of the eastern NCC (ENCC) and the western WC (WWC) utilized this weak MLDL layer to delaminate from overlying lithosphere. We first explore this hypothesis with a lubrication‐theory‐based analytical model. This model suggests a close relationship between a cratonic keel's long‐term stability and the strength of the MLDL's edge. We further test this prediction with less idealized 2‐D numerical experiments which reveal that (a) dense lower keels beneath MLDL‐bearing cratons can persist for billions of years as long as the MLDL's edges abut relatively cold and strong lithosphere; (b) MLDL edge failure can induce rapid intramantle lower keel delamination; and (c) the predicted rates of keel delamination along a ~10‐km‐thick MLDL with a hydrous olivine or metasomatic mineral‐dominated rheology are consistent with observations for the removal speeds of the WWC and the ENCC.
Impact of Convective Gravity Waves on the Tropical Middle Atmosphere During the Madden‐Julian Oscillation
Authors: Kalisch S. , Kang M.‐J. , Chun H.‐Y.
Published: August 2018

The Madden‐Julian oscillation (MJO) prominently influences weather systems in the tropical Indian Ocean region. Although understanding of the MJO has improved over the last decade, insufficient simulation of the MJO still considerably degrades forecasting skill of atmospheric models. In this study we investigate the interaction of gravity waves (GWs) from convection with the background atmosphere during MJO cycles between 1979 and 2010. For this, we utilize a parameterization of convective GW (CGW) forcing and propagation to evaluate the entire life cycle of GWs from their convective excitation to their dissipation in the tropical upper stratosphere region. CGW forcing at source level was calculated using the Song and Chun (2005, https://doi.org/10.1175/JAS-3363.1) parameterization. We performed simulations for all respective MJO phases and MJO cycles during a period of 32 years using Climate Forecast System Reanalysis data for the full spectrum of CGWs. Our results show a clear connection between 850 hPa winds and zonal momentum flux during all MJO phases. This prominent momentum flux feature changes with the progress of each MJO cycle. Zonal means of eastward directed momentum flux also show this correlation. Furthermore, we estimated the spectral characteristics of launched GWs and found significant GW momentum flux for horizontal wavelengths as short as 80 km at launch altitude. Eastward GW drag (GWD) consistently shows a maximum at altitudes below 40 km and prominent westward GWD at altitudes higher than 40 km. Additionally, we investigated the impact of the phase of the quasi‐biennial oscillation (QBO) on our findings with GWD found stronger during the QBO easterly phase compared to the QBO westerly phase.
Scraping Bottom: Iceberg Scours Reveal North Atlantic Currents
Authors: Cook Terri
Published: August 2018

A 3-D seismic analysis of Pleistocene iceberg gouges indicates that surface currents in the Norwegian Sea flowed northward and remained consistent during numerous glacial cycles.
Forcing the reversibility of a mechanochemical reaction
Authors: Beedle Amy E. M. , Mora Marc , Davis Colin T. , Snijders Ambrosius P. , Stirnemann Guillaume , Garcia-Manyes Sergi
Published: August 2018

Mechanical force modifies the free-energy surface of chemical reactions, often enabling thermodynamically unfavoured reaction pathways. Most of our molecular understanding of force-induced reactivity is restricted to the irreversible homolytic scission of covalent bonds and ring-opening in polymer mechanophores. Whether mechanical force can by-pass thermodynamically locked reactivity in heterolytic bimolecular reactions and how this impacts the reaction reversibility remains poorly understood. Using single-molecule force-clamp spectroscopy, here we show that mechanical force promotes the thermodynamically disfavored SN2 cleavage of an individual protein disulfide bond by poor nucleophilic organic thiols. Upon force removal, the transition from the resulting high-energy unstable mixed disulfide product back to the initial, low-energy disulfide bond reactant becomes suddenly spontaneous, rendering the reaction fully reversible. By rationally varying the nucleophilicity of a series of small thiols, we demonstrate how force-regulated chemical kinetics can be finely coupled with thermodynamics to predict and modulate the reversibility of bimolecular mechanochemical reactions.
Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
Authors: Arechederra Maria , Daian Fabrice , Yim Annie , Bazai Sehrish K. , Richelme Sylvie , Dono Rosanna , Saurin Andrew J. , Habermann Bianca H. , Maina Flavio
Published: August 2018

Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26Met) to explore the impact of DNA methylation on transcriptional switches associated with tumorigenesis. We identified a striking enrichment in genes simultaneously hypermethylated in CpG islands (CGIs) and overexpressed. These hypermethylated CGIs are located either in the 5′-UTR or in the gene body region. Remarkably, such CGI hypermethylation accompanied by gene upregulation also occurs in 56% of HCC patients, which belong to the “HCC proliferative-progenitor” subclass. Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change in a large proportion of HCC patients. Among reprogrammed genes, several are well-known oncogenes. For others not previously linked to cancer, we demonstrate here their action together as an “oncogene module”. Thus, hypermethylation of gene body CGIs is predictive of elevated oncogene levels in cancer, offering a novel stratification strategy and perspectives to normalise cancer gene dosages.
Crystalline polymeric carbon dioxide stable at megabar pressures
Authors: Dziubek Kamil F. , Ende Martin , Scelta Demetrio , Bini Roberto , Mezouar Mohamed , Garbarino Gaston , Miletich Ronald
Published: August 2018

Carbon dioxide is a widespread simple molecule in the Universe. In spite of its simplicity it has a very complex phase diagram, forming both amorphous and crystalline extended phases above 40 GPa. The stability range and nature of these phases are still debated, especially in view of their possible role within the deep carbon cycle. Here, we report static synchrotron X-ray diffraction and Raman high-pressure experiments in the megabar range providing evidence for the stability of the polymeric phase V at pressure-temperature conditions relevant to the Earth’s lowermost mantle. The equation of state has been extended to 120 GPa and, contrary to earlier experimental findings, neither dissociation into diamond andε-oxygen nor ionization was observed. Severe deviatoric stress and lattice deformation along with preferred orientation are removed on progressive annealing, thus suggesting CO2-V as the stable structure also above one megabar.
Coherence in carotenoid-to-chlorophyll energy transfer
Authors: Meneghin Elena , Volpato Andrea , Cupellini Lorenzo , Bolzonello Luca , Jurinovich Sandro , Mascoli Vincenzo , Carbonera Donatella , Mennucci Benedetta , Collini Elisabetta
Published: August 2018

The subtle details of the mechanism of energy flow from carotenoids to chlorophylls in biological light-harvesting complexes are still not fully understood, especially in the ultrafast regime. Here we focus on the antenna complex peridinin–chlorophyll a–protein (PCP), known for its remarkable efficiency of excitation energy transfer from carotenoids—peridinins—to chlorophylls. PCP solutions are studied by means of 2D electronic spectroscopy in different experimental conditions. Together with a global kinetic analysis and multiscale quantum chemical calculations, these data allow us to comprehensively address the contribution of the potential pathways of energy flow in PCP. These data support dominant energy transfer from peridinin S2 to chlorophyll Qy state via an ultrafast coherent mechanism. The coherent superposition of the two states is functional to drive population to the final acceptor state, adding an important piece of information in the quest for connections between coherent phenomena and biological functions.
Interphase human chromosome exhibits out of equilibrium glassy dynamics
Authors: Shi Guang , Liu Lei , Hyeon Changbong , Thirumalai D.
Published: August 2018

Fingerprints of the three-dimensional organization of genomes have emerged using advances in Hi-C and imaging techniques. However, genome dynamics is poorly understood. Here, we create the chromosome copolymer model (CCM) by representing chromosomes as a copolymer with two epigenetic loci types corresponding to euchromatin and heterochromatin. Using novel clustering techniques, we establish quantitatively that the simulated contact maps and topologically associating domains (TADs) for chromosomes 5 and 10 and those inferred from Hi-C experiments are in good agreement. Chromatin exhibits glassy dynamics with coherent motion on micron scale. The broad distribution of the diffusion exponents of the individual loci, which quantitatively agrees with experiments, is suggestive of highly heterogeneous dynamics. This is reflected in the cell-to-cell variations in the contact maps. Chromosome organization is hierarchical, involving the formation of chromosome droplets (CDs) on genomic scale, coinciding with the TAD size, followed by coalescence of the CDs, reminiscent of Ostwald ripening.
Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
Authors: Jbara Muhammad , Laps Shay , Morgan Michael , Kamnesky Guy , Mann Guy , Wolberger Cynthia , Brik Ashraf
Published: August 2018

Organic chemistry allows for the modification and chemical preparation of protein analogues for various studies. The thiolate side chain of the Cys residue has been a key functionality in these ventures. In order to generate complex molecular targets, there is a particular need to incorporate orthogonal protecting groups of the thiolated amino acids to control the directionality of synthesis and modification site. Here, we demonstrate the tuning of palladium chemoselectivity in aqueous medium for on-demand deprotection of several Cys-protecting groups that are useful in protein synthesis and modification. These tools allow the preparation of highly complex analogues as we demonstrate in the synthesis of the copper storage protein and selectively modified peptides with multiple Cys residues. We also report the synthesis of an activity-based probe comprising ubiquitinated histone H2A and its incorporation into nucleosomes and demonstrate its reactivity with deubiquitinating enzyme to generate a covalent nucleosome–enzyme complex.
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Authors: Scietti Luigi , Chiapparino Antonella , De Giorgi Francesca , Fumagalli Marco , Khoriauli Lela , Nergadze Solomon , Basu Shibom , Olieric Vincent , Cucca Lucia , Banushi Blerida , Profumo Antonella , Giulotto Elena , Gissen Paul , Forneris Federico
Published: August 2018

Lysyl hydroxylases catalyze hydroxylation of collagen lysines, and sustain essential roles in extracellular matrix (ECM) maturation and remodeling. Malfunctions in these enzymes cause severe connective tissue disorders. Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it catalyzes collagen lysine hydroxylation and also their subsequent glycosylation. Our understanding of LH3 functions is currently hampered by lack of molecular structure information. Here, we present high resolution crystal structures of full-length human LH3 in complex with cofactors and donor substrates. The elongated homodimeric LH3 architecture shows two distinct catalytic sites at the N- and C-terminal boundaries of each monomer, separated by an accessory domain. The glycosyltransferase domain displays distinguishing features compared to other known glycosyltransferases. Known disease-related mutations map in close proximity to the catalytic sites. Collectively, our results provide a structural framework characterizing the multiple functions of LH3, and the molecular mechanisms of collagen-related diseases involving human lysyl hydroxylases.
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Authors: Yu Xiaoyan , Lao Yimin , Teng Xiao-Lu , Li Song , Zhou Yan , Wang Feixiang , Guo Xinwei , Deng Siyu , Chang Yuzhou , Wu Xuefeng , Liu Zhiduo , Chen Lei , Lu Li-Ming , Cheng Jinke , Li Bin , Su Bing , Jiang Jin , Li Hua-Bing , Huang Chuanxin , Yi Jing , Zou Qiang
Published: August 2018

Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance, but the mechanisms regulating the stability and function of Treg cells have not been fully elucidated. Here we show SUMO-specific protease 3 (SENP3) is a pivotal regulator of Treg cells that functions by controlling the SUMOylation and nuclear localization of BACH2. Treg cell-specific deletion of Senp3 results in T cell activation, autoimmune symptoms and enhanced antitumor T cell responses. SENP3-mediated BACH2 deSUMOylation prevents the nuclear export of BACH2, thereby repressing the genes associated with CD4+ T effector cell differentiation and stabilizing Treg cell-specific gene signatures. Notably, SENP3 accumulation triggered by reactive oxygen species (ROS) is involved in Treg cell-mediated tumor immunosuppression. Our results not only establish the role of SENP3 in the maintenance of Treg cell stability and function via BACH2 deSUMOylation but also clarify the function of SENP3 in the regulation of ROS-induced immune tolerance.
Publisher Correction: Finding influential nodes for integration in brain networks using optimal percolation theory
Authors: Del Ferraro Gino , Moreno Andrea , Min Byungjoon , Morone Flaviano , Pérez-Ramírez Úrsula , Pérez-Cervera Laura , Parra Lucas C. , Holodny Andrei , Canals Santiago , Makse Hernán A.
Published: August 2018

The original version of this Article contained an error in the last sentence of the first paragraph of the Introduction, which incorrectly read ‘Correlation of brain activity is typically measured using functional magnetic resonance imaging (fMRI), and the correlation structure is often referred to as “fu’. The correct version states ‘referred to as “functional connectivity”2–6’ in place of ‘referred to as “fu’. This has been corrected in both the PDF and HTML versions of the Article.