bluuebunny/crossref_metadata_2025 huggingface dataset:
New Methodological Approach for Coagulation Assays Using Chicken Plasma Intrinsic Properties
Authors: BC Prezoto , MVA Falla , I Lebrun
Published: April 2024

Background: Sensitivity of classical coagulation assays by using mammalian plasmas to pro- and anticoagulant compounds including venom or toxins occurs on a microscale level (micrograms). Although it improves responses to agonists, recalcification triggers a relatively fast thrombin formation process. The Recalcification Time (RT) of factor XII- deficient Chicken Plasma (CP) is comparatively long (=1800 seconds) when compared to human plasma or others. Our objective was to compare its sensitivity with that presented by human plasma samples to Unfractionated Heparin (UH), a prototype anticoagulant compound, under similar conditions through rotational thromboelastometry. Methods: To find doses of UH sufficient enough to prolong the Clotting Time (CT) parameter of these activated plasmas to values within their normal RT ranges. Results: In total, 0.0065±0.0009 IU of UH (n=6) was detected in 260μL of CP samples, but only 0.125±0.012 IU of UH was sufficient to induce a similar effect in activated human plasma samples. Conclusion: The higher sensitivity of CP to anticoagulants could be useful for (a) detection of anticoagulant compounds in substances of unknown origin; (b) purification procedures of anticoagulant toxins from crude animal venoms and (c) determination of relative potencies of agonists and their selective antagonists such as pharmaceutical agents, antivenoms or natural inhibitors of venom toxins with a better result in kinetic clothing parameters. Keywords: Coagulation process; Chicken; Factor XII deficiency; Animal models; Biomedical research; Rotational thromboelastometry
Fibrinogen Cleavage by Lectin Pathway Proteases: Roles and Implications
Authors:   All India Institute of Medical Sciences, Patna, India, M Madhuri , P Kumari ,   All India Institute of Medical Sciences, Patna, India, A Ali ,   All India Institute of Medical Sciences, Patna, India, D Roy ,   All India Institute of Medical Sciences, Patna, India, S Hajela ,   Mahakaushal University, Jabalpur, Madhya Pradesh, India, B Kumari ,   All India Institute of Medical Sciences, Patna, India, K Hajela ,   School of Life Sciences, DAVV, Indore, India, S Sharma ,   All India Institute of Medical Sciences, Patna, India
Published: April 2024

The lectin pathway proteases (MASPs) are diverse in regard to their substrate selectivity and also have substrates outside the complement pathway. These proteases have been reported to cleave proteins of the coagulation cascade. MASP-1 has thrombin-like activity and therefore cleaves fibrinogen, fibrin and prothrombin. MASP-2 also participates in coagulation by cleaving prothrombin. Thus, these proteases are key players in the process of thrombosis and thrombolysis, therefore have implications in thrombotic vascular diseases. The cleaved fragments of fibrinogen and fibrin, consequently produced during coagulation and fibrinolysis, are important in the repair process and hence may have involvement in inflammatory and fibro-proliferative diseases. Also, altered levels of MBL and its associated serine proteases reported to be involved in different diseases such as cardiovascular diseases, diabetes, cancer, sepsis, stroke, COVID-19 etc. may have a role in thrombosis and thrombolysis. Upregulated lectin pathway-associated proteins predispose towards autoimmune disease susceptibility and may also exhibit off-target activities resulting in clot formation. Thus, the lectin pathway and its associated proteases are of great importance in normal circumstances where it plays a role in the maintenance of hemostasis and homeostasis, playing a preventive role in infections. Modulation in the level of MASPs proteases could be developed as a promising approach to treat a variety of infections and diseases.
Clinical Profile and Bleeding Outcome of Pediatric Rare Bleeding Disorders: The Royal Hospital’s Experience, Oman
Authors:   The Royal Hospital, Ghala St, Muscat, Oman, I Al-Ghaithi , H Al-Hasani ,   The Royal Hospital, Ghala St, Muscat, Oman, A Al-Roshdi ,   The Royal Hospital, Ghala St, Muscat, Oman, M AL-Saadi ,   The Royal Hospital, Ghala St, Muscat, Oman, A Al-Amri ,   The Royal Hospital, Ghala St, Muscat, Oman
Published: April 2024

Introduction: Rare Bleeding Disorders (RBDs), a group of inherited coagulation factor deficiencies, are more common in areas with a high rate of consanguineous marriages. Data on the frequency and outcome of RBDs among children in Oman are limited. Aim: This study evaluated the clinical profile and bleeding outcomes of paediatric RBDs at the Royal Hospital, the largest referring centre in Oman, from 2010 to 2020. Methods: This retrospective descriptive cohort study includes all Omani children, less than 13 years of age, diagnosed with RBDs, and followed at the Royal Hospital. The patient’s data was retrieved from the electronic chart system. Results: Forty-one patients (24 males and 17 females) were included. Based on factor level at diagnosis, 34(83%) patients have factor VII deficiency, four (9.7%) patients have factor XIII deficiency, one (2.4%) patient has fibrinogen deficiency, and one patient (2.4%) has factor X deficiency. Four (9.4%) patients required blood transfusion for active bleeding, 15(36.6%) patients were treated on demand with tranexamic acid, and 3(7.3%) patients were on regular prophylaxis with tranexamic acid. The mean period of follow-up was 3.15 years. The majority (87.8%) of patients had no active bleeding, and only two (4.9%) patients developed severe bleeding. The mean annual bleeding rate outcome was 0.2, 0.5, and 7 for patients with FVII, FXIII, and FX, respectively. Conclusions: Omani children with rare bleeding disorders are commonly diagnosed incidentally. They usually do not require active treatment because their bleeding outcome is favourable.
Intravascular Large B-Cell Lymphoma Detected by Cutaneous Biopsy with Pancytopenia and Negative Bone Marrow Biopsy
Authors:   Department of Dermatology, Park Nicollet Health System, USA, N Battis , S Gardeen ,   Department of Dermatology, Health Partners Institute, USA, A Kozlowski ,   Department of Dermatology, Health Partners Institute, USA, L Furda-Raine ,   Department of Dermatology, Park Nicollet Health System, USA
Published: April 2024

Intravascular large B-cell lymphoma is a B-cell lineage neoplasm, which is typically recognized as a high-grade neoplasm with poor outcomes. Though rare, the cutaneous variant can present with multiple lesions of the skin and negative systemic staging. We present a case of intravascular large B-cell lymphoma first identified on cutaneous biopsy, with pancytopenia, in addition to negative bone marrow biopsy and serum protein electrophoresis. The patient is a 71-year-old male who presented with upper body pruritis and pancytopenia, as well as weight loss and fatigue. A full body skin exam incidentally revealed a well-demarcated, firm, bound down atrophic lichenified plaque on the right anterior thigh. A punch biopsy revealed large, atypical lymphoid cells exclusively localized within the lumina of variably sized blood vessels, immunoreactive for CD20, BCL6, MUM1, and CD5, but negative for CD3, CD10, cyclin D1, and TdT. A diagnosis of intravascular large B-cell lymphoma was made, and he was referred to oncology for further treatment. Full body skin exam is a mainstay of dermatologic practice, and it is essential to pursue biopsy with uncharacteristic lesions, regardless of the presenting concern.
Monoclonal Gammopathy of Undetermined Significance and Smoldering Myeloma
Authors:   Universitätsklinikum Düsseldorf, Heinrich-Heine-University, Germany Electronic address: amelie.boquoi@med.uni-duesseldorf.de., Boquoi Amelie
Published: April 2024

Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Myeloma (SMM) describe pre-malignant conditions that are defined by the presence of monoclonal immunoglobulin production. They are found in up to 3% of individuals over the age of 50 with a rate of progression to multiple myeloma or other related malignancy of approximately 1% per year. Accurate diagnosis and risk-stratification are paramount to prevent end-organ damage and determine follow-up intervals. With the data currently available, treatment for MGUS is not recommended. Patients with newly diagnosed high- risk SMM should be referred to a centre and therapy with lenalidomide plus/minus dexamethasone for 2 years or participation in a clinical trial should be discussed.
Diminished Effects of Educational Attainment on Time Spent on Substance/Drug Use in Latino Individuals: Analysis of the American Time Use Survey (ATUS)
Authors:   Marginalization-Related Diminished Returns (MDRs) Research Center, Charles R Drew University of Medicine and Science, Los Angeles, California, USA, S Assari , B Najand ,   Marginalization-Related Diminished Returns (MDRs) Research Center, Charles R Drew University of Medicine and Science, Los Angeles, California, USA, JD Schaefer ,   Institute of Child Development, University of Minnesota, Minneapolis, MN, USA
Published: April 2024

Background: While socioeconomic status (SES) indicators such as educational attainment are among the major drivers of health behaviors such as substance use, the protective effects of these indicators may differ across ethnic groups. Built on the Marginalization related Diminished Returns (MDRs) phenomenon that refers to weaker health effects of SES indicators for marginalized and minoritized groups (vs. non-Latino White people), we conducted this study with two aims: First to test the association between educational attainment and time spent on substance/drug use, and second, to test for ethnic variation in this association. Methods: This cross-sectional study used the American Time Use Survey (ATUS 2019) data. Participants included 7380 individuals who were either Latino or non-Latino White. We tested for associations between time spent on substance/drug use and a continuous measure of educational attainment using linear regression. Age and sex were control variables. We used logistic regression for sensitivity analysis using any time spent on substance/drug as the outcome. Results: Overall, high educational attainment showed an inverse association with time spent on substance/drug use overall. We also documented a statistical interaction between ethnicity and educational attainment such that associations between educational attainment and time spent on substance/drug use was weaker in Latino vs. non-Latino White individuals. We could replicate the results using logistic regression for any time spent on substance/drug as the outcome. Conclusion: We observe that SES indicators such as educational attainment may have a differential protective effect against time spent on substance/drug use for diverse ethnic groups. In contrast to non-Latino White individuals, Latino individuals reported spending similar amounts of time on substance/drug use across the full SES spectrum. This finding is in line with the MDRs framework and may be attributable to the effects of structural racism, social stratification, and marginalization impacting ethnic minorities in the United States.
Effectiveness of Islamic Spiritual Care Education for Parents on Quality of Life and Chronic Pain of Children with Cancer
Authors:   Department of Psychology & Education, Shahid Beheshti University, Tehran, Iran, S Borjalilu , MA Mazaheri ,   Department of Psychology & Education, Shahid Beheshti University, Tehran, Iran
Published: April 2024

Aims: Studies showed that spiritual care is a good mechanism of coping for parents with children suffering from cancer. The purpose of this study is to investigate the effect of parents’ Islamic spiritual care on pediatric quality of life and chronic pain in children with cancer. Instrument and Methods: A semi-experimental study was performed at Mahak Hospital in Tehran, Iran. Forty-five child-parent pairs were assigned into the experiments (n = 25) and control groups (n = 20). The parents of children with cancer in the intervention group received eight sessions of Islamic spiritual care of the child with cancer lasting between 80–90 minutes. The control group received only routine standard care. All parents completed the Spirituality & Spiritual Sare Rating Scale (SSRS) and all children with cancer completed the pediatric quality of life inventory and Oucherpain scale before and after the interventions. The data was analyzed in SPSS-21. Findings: There was significant difference between attitudes of parents toward spirituality and spiritual care between two groups (F=10.02; P<0.01; η2=0.48). The mean of ‘Spirituality’ in the experimental group was 3.73 at pretest, 4.11 post-test and 4.4three months after the sessions. Also, the results showed that spiritual care training of parents improved the pediatric quality of life. The mean children quality of life in experimental group was 3.39 at pretest, 4.16 post-test and 4.22 three months later (F=12.46; P<0.01; η2=0.41) and hence a decreased pain perception in children with cancer during follow-up. The mean of pain perceived among children with cancer was 8.96 at per-test, 7.42 posttest and 4.89 at follow up. (F=15.33; P<0.01; η2=0.33). Conclusions: The results showed that spiritual care training of parents increases their attitude toward spiritual care for their children. In this regard, the impact of current training increases pediatric quality of life and reduces the intensity of pain among children with cancer.
Management of Hypertension and Diabetes in Health Centers in Sub Saharan Africa Countries
Authors:   Internal Medicine Unit, Isber Clinic, Varese, Italy, A Sessa , G Cecchini ,   Doctors with Africa NGO – CUAMM ONLUS, Padua, Italy, L Chiappa ,   Doctors with Africa NGO – CUAMM ONLUS, Padua, Italy, G Putoto ,   Doctors with Africa NGO – CUAMM ONLUS, Padua, Italy, D Carraro ,   Doctors with Africa NGO – CUAMM ONLUS, Padua, Italy
Published: April 2024

Non-communicable diseases are increasing the incidence and prevalence in last ten years and only now national health systems are looking this phenomenon and they are searching to improve strategies to limit damages. Non-governmental organizations that work in these countries can contribute to improve strategies and tools against these chronic diseases.
Reducing food losses as a tool for managing economic and social development
Authors: Zinina O. V. , Olentsova Ju. A.
Published: April 2024

The principles of rational production and consumption are one of the key themes of “The 2030 Agenda for Sustainable Development”. Today, most countries of the world are implementing various initiatives aimed at creating a closed-cycle economy, at rational use of natural resources, at preservation of the environment and natural biodiversity, at the development of rational ways to produce, sell, and consume food. The amount of food waste has increased significantly and become a global problem amid growing concern about hunger in a number of states. Food-sharing is a solution to the problem, provided that an appropriate structure is developed that will guide its application. The sharing economy was named as a suitable basis. The autonomous non-commercial organisation “Food-sharing” was chosen as an object in this study. The key goal of the study is to optimise the daily work of the volunteer, coordinator and organisation as a whole that deals with this problem. Possible parameters for the analysis: the volume of products received during the period, the sources of products received, the categories to which they belong (fruits, bakery products, meat, etc.), the geography of exports, the number of volunteers involved during the period, the number of final recipients during the period.
Adaptive potential of Russian economic growth in the context of decline in foreign direct investment
Authors: Krasnykh S. S.
Published: April 2024

This study analyses the adaptive potential of Russia’s economic growth in the context of decline in foreign direct investment (hereinafter referred to as FDI). In light of today’s geopolitical environment, marked by increased trade tension and protectionist measures, understanding the impact of FDI on Russia’s gross domestic product (hereinafter referred to as GDP) becomes critical for policy-making and economic planning. The study employs a vector autoregression modeling approach (hereinafter referred to as VAR) to analyse the dynamics of Russia’s GDP and FDI inflows with consideration to various economic and geopolitical factors. Besides, an extensive dataset is used covering the period from 1996 to 2021 which includes relevant macroeconomic indicators and geopolitical events. The VAR model allows to study short- and long-term correlations between variables reflecting dynamic interaction and feedback effects. In addition, impulse response analysis is used to estimate the magnitude and sustainability of economic growth under conditions of economic instability. The results of the study contribute to understanding the adaptative potential of Russia’s economic growth in the context of FDI restrictions from Western countries. The analysis provides insight into the significance of FDI inflows for the Russian GDP with consideration to the impact of various economic and geopolitical factors.
Managerial challenges in the conditions of digitalisation. A review of the book “Management for digital transformation” (Springer, 2024)
Authors: Ruban D. A.
Published: April 2024

The active processes of digitalisation of socio-economic systems require modifications of managerial activities which should be facilitated by relevant scientific developments. This article is a review of the monograph devoted to peculiarities of management in the conditions of digital transformation and written by the international team of specialists. The work includes 9 main chapters which address very different aspects of the problem and particularly control during digitalisation, technology transfer, talent management, interaction with customers, marketing tools, e-commerce, functioning of virtual teams, inter-organisational collaboration, management of digital waste. Generally, it is found that despite the fact that digitalisation opens new perspectives for managerial activities, it also forms significant difficulties, and its effects are ambivalent or can often be negative. The considered research field seems to be rather poorly studied, and the monograph successfully poses new questions for the subsequent investigations. The reviewed work demonstrates the mosaic composition; nonetheless, it is informative and offers an original view of the problem. It contains a lot of interesting conceptual constructs and is rich in factual materials. Also, the edition is distinguished by a substantial number of terms, and the available subject index facilitates better orientation in the latter. The style is purely academic, but the potential readership seems to be wide. Despite a few minor deficiencies, the monograph, undoubtedly, will be interesting to Russian specialists.
A General Nucleation Model For Semiconductor Nanocrystals
Authors: Chen Zifei , Russo Salvy , Mulvaney Paul
Published: April 2024

We introduce a non-classical model for nanocrystal nucleation in solution which centers on the dynamic interplay of chemical bond breakage and formation, coupled with the desolvation of precursor molecules. Departing from classical theory, our model employs the bond count as the key variable rather than particle size, thereby redefining the role of supersaturation and its role in determining the so-called critical nucleus size. We apply the model to CdSe nanocrystal formation in non-polar solvents and showcase its efficacy in predicting solvent dynamics, precursor characteristics, crystal phase, stoichiometry," magic number" behavior, and transition states. While the coupled-cluster method is used to determine the bond energy, we show that it is possible to derive reaction pathways by reducing the calculations to algebraic approximations for the nucleation energy. This singular set of bond energy parameters allows nanocrystal nucleation and growth to be conceptualized as a straightforward chemical reaction.
Density Fitted Fragment Embedding – Principles and Applications
Authors: Sun Yi
Published: April 2024

We demonstrate how deterministic, stochastic and semistochastic density fitted fragment embedding can be constructed using both non-overlapping fragments and overlapping fragments to perform energy evaluations. We then implement the frameworks to first perform energy calculations on water clusters using a polarised 3-zeta basis set to demonstrate the observed scaling of the algorithms, which is $\mathcal{O}(N_{AO,\text{mol}}^{2.62})$ and stochastic algorithms can help to reduce the pre-factor. We then perform numerical structural optimisations on cyclic water and hydrogen fluoride clusters using the deterministic algorithm. The optimised structures' hydrogen bonding energies are then compared with results using the corresponding correlated all-electron solver, which is CCSD in this work. It turns out that if each interacting molecule is chosen as a fragment, d-BE1-DF-CCSD is able to recover almost all of the hydrogen bonding energy in both water and hydrogen fluoride clusters calculated using all-electron DF-CCSD. This work therefore provides foundations for the efficient generation and quality of fragment embedding energy data in large, weakly interacting systems.
Electrochemical nitrogen reduction reaction to ammonia using perovskite-type oxynitrides BaMO2N (M = Nb, Ta) and enhancement of the activity by acid treatment
Authors: Kusano Haruka , Miura Akira , Higuchi Mikio , Masubuchi Yuji
Published: April 2024

The electrochemical nitrogen reduction reaction (ENRR) to NH3 is one of the potential alternatives to the Harber-Bosch (HB) process. Metal nitrides and oxynitrides have been proposed as suitable catalysts. However, an ENRR catalyst that is stable during the ENRR and demonstrates a high Faradaic efficiency (FE) has never been reported. Perovskite-type oxynitrides, BaMO2N (M = Nb, Ta) are promising catalysts for the ENRR because of the coexisting of N vacancies that function as N2 mole-cule adsorption sites and a robust crystal lattice resulting from the metal-oxygen bonds. Herein, we demonstrate electro-chemical NH3 production using the perovskite oxynitride catalysts with high FE values over 60%. The Ta and Nb oxynitrides showed NH3 production rates of 6.8 and 9.2 μgNH3/h·mgcat, with the FE values of 73% and 39%, respectively. Acid treatment using 6 M nitric acid enhanced their activity to 8.0 and 15 μgNH3/h·mgcat with 63% and 67% of FE values for the Ta and Nb oxynitrides, respectively. The amount of NH3 produced was approximately ten times larger than the nitrogen content of the oxynitride catalysts, indicating that the NH3 was dominantly produced from N2, not from decomposition of the catalysts.
Electrochemical Synthesis of the in human S-oxide metabolites of phenothiazine containing Anti-Psychotic Medications
Authors: Asra Ridho , Malmakova Aigul , Jones Alan
Published: April 2024

The tractable preparation of phase-I drug metabolites is a critical step to understand the first-pass behaviour of novel chemical entities in drug discovery. In this study we have developed a structure electroactivity relationship (SeAR) informed electrochemical reaction of the parent 2-chlorophenothiazine and anti-psychotic, chlorpromazine. The ability to dial-in under current controlled conditions the formation of S-oxide and novel S,S-dioxide metabolites has been achieved for the first time on a multimilligram scale using a direct batch electrode platform. A potential rationale for the electrochemical formation of these metabolites in situ is proposed using molecular docking to a cytochrome P450 enzyme.
Adaptive Lambda Scheduling: A method for computational efficiency in Free Energy Perturbation simulations
Authors: Midgley Scott , Bariami Sofia , Habgood Matthew , Mackey Mark
Published: April 2024

Despite growing accessibility due to advances in computing power, ligand-protein Relative Binding Free Energy (RBFE) calculation remains a resource-intensive activity, which limits its practical application. Improved computational efficiency via bespoke sampling of the alchemical transformation coordinate, λ, is under-explored. We show here that a simple approach for on-the-fly bespoke λ scheduling, named Adaptive Lambda Scheduling (ALS), yields significant reduction in computational cost whilst retaining predictive performance.
An efficient state specific frozen natural orbital based equation of motion coupled cluster method for core-ionization energies: theory, implementation and benchmark
Authors: Manna Amrita , Jangid Bhavnesh , Pant Rakesh , Dutta Achintya Kumar
Published: April 2024

We have implemented a reduced-cost partial triples correction scheme to the equation of motion coupled cluster method for core-ionization energy based on state-specific natural orbitals. The second-order Algebraic Diagrammatic Construction (ADC) method is used to generate the state-specific natural orbital, which provides quicker convergence of the core IP value with respect to the size of the virtual space than that observed in standard MP2-based natural orbitals. The error due to the truncation of the virtual orbital can be reduced by using a perturbative correction. The accuracy of the method can be controlled by a single threshold and is a black box to use. The inclusion of the partial triples correction in the natural orbital based EOM-CCSD method greatly improves the agreement of the results with the experiment. The efficiency of the present implementation is demonstrated by calculating the core-ionization energy of a molecule containing 60 atoms and more than two thousand basis functions.
peptidy: A light-weight Python library for peptide representation in machine learning
Authors: Özçelik Rıza , van Weesep Laura , de Ruiter Sarah , Grisoni Francesca
Published: April 2024

In this work, we introduce peptidy -- a lightweight Python library that facilitates converting peptides (expressed as aminoacid sequences) to numerical representations suited to machine learning. peptidy is free from external dependencies, integrates seamlessly into modern Python environments, and supports a range of encoding strategies suitable for both predictive and generative machine learning approaches. Additionally, peptidy supports peptides with post-translational modifications, such as phosphorylation, acetylation, and methylation, thereby extending the functionality of existing Python packages for peptides and proteins. peptidy is freely available with a permissive license on GitHub at the following URL: https://github.com/molML/peptidy
1,6-Thiol Addition of Trifunctional N-Alkylpyridinium for Site-selective Dual Functionalization of Proteins
Authors: Weil Tanja , Kuan Seah Ling , Xu Lujuan , Silva Maria J. S. A. , Coelho Jaime A. S. , Borho Joscha , Stadler Nicole , Barth Holger
Published: April 2024

We report N-alkylpyridinium reagents for site-selective dual modification of proteins via a regioselective 1,6-thiol addition reaction. The N-alkylpyridinium derivatives can be syn-thesized in two reaction steps and demonstrate high labelling efficiency and chemose-lectivity towards cysteine residues. This reaction is combined with strain-promoted azide-alkyne click and inverse-electron-demand Diels−Alder reactions to achieve dual functionalization of proteins in a sequential one-pot reaction. A Rho-inhibiting enzyme is functionalized with a cancer cell-targeting peptide and a fluorescent dye for successful in vitro uptake imaging and concomitant inhibition of specific Rho-mediated cellular pathways. The ease of synthesis, fast kinetics, high solubility and regioselectivity make N-alkylpyridinium reagents unique for protein/peptide modification to increase their functional diversities for medical applications.
In situ crosslinkable small molecule organic cathode with self-nanostructuring property for stable and fast-rechargeable batteries
Authors: Lee Kyunam , Serdiuk Illia E. , Kim Jihyeon , Min Dong Joo , Park Hyunji , Kang Kisuk , Park Soo Young , Kwon Ji Eon
Published: April 2024

Redox-active organic materials (ROMs) for energy storage devices are emerging as sustainable alternatives to inorganic cathode materials. However, the development of high-performance organic cathodes has been challenged by the incompatibility between the insolubilization of ROMs for high stability and the fabrication of electrodes with high surface area for high-rate capability. Herein, we present a small-molecule organic cathode material, 1,3,5-tris(3-vinyl-10H-phenoxazin-10-yl)benzene (V3PXZ), that overcomes this limitation by in situ electrochemical crosslinking in the cell after electrode fabrication using soluble small-molecule. V3PXZ is designed to form a non-conjugated polymer without byproducts through in situ electrochemical crosslinking to ensure the coupling reaction does not degrade cell performance. This method not only yields an insoluble network of V3PXZ, but also forms nanostructures with high surface area in the electrode. Utilizing self-nanostructuring, we demonstrate an aqueous-processed V3PXZ cathode operating at a voltage of 3.87 V vs. Li/Li+, comparable to inorganic cathodes. Notably, V3PXZ simultaneously achieves the highest cycling stability (capacity retention of 99.995% per cycle over 10,000 cycles) and rate capability (charging 56% of total capacity in 36 seconds) with the highest active content (70 wt%) among the small molecule organic p-type cathodes reported to date.
Fabrication of High-Density Microarchitected Tungsten via DLP 3D Printing
Authors: Cai Junyu , Ma Songhua , Yi Wenbin , Wang Jieping
Published: April 2024

Current additive manufacturing (AM) techniques for tungsten, such as powder bed fusion and directed energy deposition, often generate parts with rough surfaces. Vat photopolymerization presents a promising alternative for fabricating intricate tungsten structures with high shape fidelity and low surface roughness. However, existing vat photopolymerization approaches suffer from surface defects and low final density, leading to compromised mechanical properties. Therefore, achieving high-density tungsten structures using vat photopolymerization remains a crucial challenge. This work presents a straightforward and reliable method for fabricating complex, micro-architected tungsten structures with superior density and hardness. The approach utilizes a water-based photoresin with exceptional tungsten ion loading capacity. The photoresin is then patterned using digital light processing (DLP) to create intricate tungsten-laden precursors. A meticulously designed three-step debinding and sintering process subsequently achieves three-dimensional tungsten structures with dense surface morphology and minimal internal defects. The microstructures achieve a minimum feature size of 35 μm, a low surface roughness of 2.86 μm, and demonstrate exceptional mechanical properties. This new method for structuring tungsten opens doors to a broad range of applications, including micromachining, collimators, detectors, and metamaterials.
Accuracy of projected atomic virtual orbital space in embedding applications
Authors: Szirmai Ádám B. , Barcza Bónis , Tajti Attila , Szalay Péter G.
Published: April 2024

The performance of the recently suggested projected atomic orbitals (PAO) approach as the virtual space in excited state projection-based embedding applications is analyzed. The role of the parameters in the PAO generation is discussed and the impact of different choices is evaluated on the ground state of the stacked formaldehyde and pyrrole dimers. A comparison of excitation energies obtained with PAOs and localized virtual orbitals is given and the role of diffuse basis functions is discussed using a benchmark set from previous studies.
Injectable and photocurable precursors with their improved adhesive elastomeric films by nature-inspired marine mussels chemistry
Authors: Demirci Gokhan , Niedzwiedz Malwina , Stefaniak Nina , Sobolewski Peter , El Fray Miroslawa
Published: April 2024

Photocurable materials, capable of being delivered as liquids and rapidly cured in situ within seconds using UV light, are garnering increased interest in advanced minimally invasive procedures. Examining living organisms to extract novel principles and technologies, and subsequently applying them into synthetic materials to enhance their performances holds a central position in biomimetics (bioinspiration). In this exploration, we delve into the multifaceted world of marine mussel adhesion, emphasizing the pivotal role of 3,4-dihydroxy-L-phenylalanine (L-DOPA) in adhesive proteins. Simultaneously, we navigated the promising realm of elastomers derived from fatty acid dimers. 90° peeling test and fluorescence microscope indicate that the adhesiveness of the catechol-containing samples (5% and 10%) versus control samples were ~4 and 8 times higher, respectively, as compared to within the tested group. Overall, our results suggest that the incorporation of methacrylated L-DOPA in the synthesis of photocured elastomeric networks leads to improved water contact angle and adhesiveness, creating new avenues for potential biomedical applications.
THE ROLE OF BIG FIVE PERSONALITY ON INDIVIDUAL INNOVATIVE WORK BEHAVIOR OF EMPLOYEES
Authors: Aldrin Jessica , Hastuti Rahmah
Published: April 2024

Work skills enable employees to be able to complete assigned tasks successfully, efficiently and without any problems. The job skill that will be increasingly sought after is innovation. Innovative work behavior can be influenced by external factors and internal factors. One of the internal factors that influence employee innovative work behavior in the workplace is personality. The big five personality is a personality that can predict and explain individual behavior. The purpose of this study is to determine the impact of the big five personality traits on individual employees’ innovative work behavior. This study involved 166 employees consisting of 66 male employees and 100 female employees of PT X. PT X is one of Indonesia’s private banks. The data were collected using purposive sampling and the type of research used was non-experimental research with quantitative methods. The scale used were the innovative work behavior scale (α = 0.915) and the international personality item pool-five factor inventory (α = 0.904). The results of the analysis show that the extraversion dimension contributes 19%, agreeableness contributes 11.5%, conscientiousness contributes 11.2%, neuroticism contributes 6%, and openness to experience contributes 29.7% to employees’ innovative work behavior.
ENTREPRENUERS’ OPERATIONAL RISKS AND SERVICE STRATEGY: A REVIEW DURING PANDEMIC
Authors: DBA Elaine Joy C. Apat,
Published: April 2024

The economic impact of the coronavirus disease (COVID-19) is unprecedented and uncertain. No matter the firm, sector, or industry, the pandemic has forced the world to adapt to the current conditions. This paper was focused on the valuation of operational risks and its perceived effects on the service strategy of small and medium businesses in Laguna Province during pandemic. Descriptive type of research and purposive sampling technique were employed with 136 retrieved and treated questionnaires. The self-made questionnaire undertook pilot testing with acceptable to good internal consistency. Data were assessed using tools in statistics such as frequency, rank, mean, weighted mean and anova. The highest weighted mean for the operational risks relative to management is the Untimely management during strategy – setting process in accepting risk. Whereas, in terms of waste identification, High staff turnover, got the highest weighted mean. On the other hand, service strategy was described in moderate performance by the business owners. Management and waste identification in operational risks have significant difference when grouped according to type of service business. Whereas service strategy resulted to have significant differences in business category as to capital, number of employees and type of service business. The findings recommended that Local Government and businesses may create programs that may more greatly assist the industry to fully recover from the effects of the pandemic.
lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation
Authors: Morgenstern Eva , Molthof Carolin , Schwartz Uwe , Graf Johannes , Bruckmann Astrid , Hombach Sonja , Kretz Markus
Published: April 2024

Numerous long non-coding RNAs (lncRNAs) were shown to have a functional impact on cellular processes such as human epidermal homeostasis. However, the mechanism of action for many lncRNAs remains unclear to date. Here, we report that lncRNA LINC00941 regulates keratinocyte differentiation on an epigenetic level through association with the NuRD complex, one of the major chromatin remodelers in cells. We find that LINC00941 interacts with NuRD-associated MTA2 and CHD4 in human primary keratinocytes. LINC00941 perturbation changes MTA2/NuRD occupancy at bivalent chromatin domains in close proximity to transcriptional regulator genes, including theEGR3gene coding for a transcription factor regulating epidermal differentiation. Notably, LINC00941 depletion resulted in reduced NuRD occupancy at theEGR3gene locus, increased EGR3 expression in human primary keratinocytes, and increased abundance of EGR3-regulated epidermal differentiation genes in cells and human organotypic epidermal tissues. Our results therefore indicate a role of LINC00941/NuRD in repressing EGR3 expression in non-differentiated keratinocytes, consequentially preventing premature differentiation of human epidermal tissues.
Strategi peningkatan layanan perizinan melalui online single submission risk-based approach (oss rba) di Jawa Tengah
Authors: Devita Rina Gusma , Widjajanti Kesi , Wardoyo Paulus
Published: April 2024

Penelitian ini merupakan studi mengenai strategi yang dilakukan dalam meningkatkan kemudahan layanan perizinan melalui sistem OSS RBA di Provinsi Jawa Tengah dengan pendekatan kualitatif dan teknik pengumpulan data melalui wawancara mendalam, observasi dan arisp/dokumentasi. Teknik analisis data melalui reduksi data, penyajian data dan penarikan kesimpulan. Dari hasil penelitian terdapat faktor penghambat dalam penerapan sistem OSS RBA yaitu faktor internal dan eksternal. Faktor internal berupa kendala pada sistem, integrasi sistem dengan berbagai kementerian belum terlaksana dengan baik, adanya regulasi yang tumpang tindih, adanya jenis izin yang belum diakomodir, terbatasnya room upload persyaratan serta terbatasnya jumlah petugas layanan. Faktor eksternal berupa ketidakmampuan pelaku usaha mengakses OSS RBA. Strategi yang di gunakan dalam meningkatkan kemudahan layanan perizinan berusaha di Jawa Tengah melalui strategi teknologi dengan memanfaatkan teknologi informasi dan komunikasi melalui kanal zoom, email serta kontak langsung dengan Kementerian Investasi. Strategi inovasi berupa inovasi digitalisasi layanan perizinan melalui SIAP Jateng dan Lakon-e Pandu. Strategi operasi melalui melalui Gerai Provinsi, klinik investasi dan kegiatan pendidikan serta pelatihan bagi petugas layanan perizinan.

This research is a study on the strategies employed to improve the ease of licensing services through the OSS RBA system in Central Java Province, using a qualitative approach and data collection techniques including in-depth interviews, observations, and documentation analysis. Data analysis techniques involve data reduction, data presentation, and conclusion drawing. The research findings reveal inhibiting factors in the implementation of the OSS RBA system, both internal and external. Internal factors include system constraints, incomplete system integration with various ministries, overlapping regulations, unaccommodated types of permits, limited room for uploading requirements, and a shortage of service officers. External factors involve the inability of business actors to access the OSS RBA. Strategies used to enhance the ease of licensing services in Central Java Province include technological strategies utilizing information and communication technology through Zoom channels, email, and direct contact with the Ministry of Investment. Innovative strategies include digitalization innovations in licensing services through SIAP Jateng and Lakon-e Pandu. Operational strategies involve provincial outlets, investment clinics, educational activities, and training for licensing service officers
Characterization of flavor-related compounds and sensory profiles of four
fermented fish products prepared from silver rasbora (Rasbora argyrotaenia)
and anchovy (Stolephorus sp.)
Authors: Rachmawati S.H. , Widiastuti I. , Ridhowati S. , Umami A. , Vandiwinata I. , Lestari S.D.
Published: April 2024

Fermented fish products are grouped into salt and salt-carbohydrate types based on the
fermentation substrate. A series of biochemical reactions on the substrate affects the flavor
characteristics of the resulting products. This study compared the amino acids, fatty acids,
and volatile compound profiles of four fermented fish products: bekasam, rusip, fish paste,
and fish sauce made from silver rasbora and anchovy. The quantitative descriptive
analysis (QDA) was carried out to determine the sensory profiles of those products. The
results indicated that rusip and bekasam, which belong to salt-carbohydrate fermented
fish, were characterized as high in arginine, stearic, capric, and oleic acid, with ketones,
lactones, and fatty acid derivative compounds dominating their flavor profiles. The flavor
profile of fish paste was characterized by high concentrations of aldehydes such as 3-
methylbutanal and hexanal, whereas that of fish sauce was characterized by large
concentrations of pyrazine and aromatic compounds. Based on the findings of the QDA,
no significant difference was observed within the sensory variables of fish sauce and fish
paste prepared from anchovy and silver rasbora, indicating that both fish are equally
usable as raw materials. Whereas different saltiness was identified in both rusip and
bekasam prepared from anchovy and rasbora. The results of PCA on QDA data separated
fermented fish type 1 from the type 2. Fermented fish type 1 was more correlated with
umami and sweet taste, while type 2 was correlated with fishy, salty, sour, and astringent
taste. The result is useful as a basis for further product development and quality control.
The Dueling Forces of DEI Efforts and Institutional Racism in Higher Education: The Relationship Between Leadership Diversity and Student of Color Completion Rates
Authors:   , DeMarina Sara
Published: April 2024

This exploratory study used abstraction and a snapshot in time to investigate the interacting dynamic forces of institutional racism and DEI efforts in higher education. Despite decades of DEI efforts by institutions of higher education, rates of representation in senior leadership have been marginal. Similarly, completion rates for students of color (SOC) have been persistently low. This research used pre-pandemic data from the Integrated Postsecondary Education Data System (IPEDS) for the academic year 2019-2020 to determine if varying degrees of senior leadership (administrators and tenured professors) had a significant effect on completion rates for SOC. Literature has highlighted that there is a general perception that increased numbers of people of color (POC ) on college campuses equates to effective DEI efforts. This study helps to dispel that notion and adds to the literature by using three critical theories to frame and contextualize the research and the data. Using Quantitative Critical Theory (QuantCrit) and two models by Hurtado et al. (2012) and Cheng (2021), this study evaluated DEI effectiveness on two dimensions: the compositional (addressing numbers) and the organizational (addressing equity and inclusion). This research used both an Analysis of Variance (ANOVA) and multiple regression to analyze the data.
“That’s Where I Learned Really How Sex Works:” Asian American and Pacific Islander Men who are Attracted to Men Supplementation of Sexual and Romantic Education through Media
Authors:   , Barrera-Sandri Iyan
Published: April 2024

Sexual and romantic education fails to provide the needed information for many students who are non-heteronormative or part of the dominant Euroamerican population (Currin et al., 2017; Currin et al., 2019; Elia & Eliason, 2010; Estes, 2016). One such group of nonheteronormative students are men who are attracted to men (MAM) (Albury, 2015; Attwood et al., 2015; Currin et al., 2017; Currin, et al., 2019). For this group, students have turned to peers and media to supplement their formal sexual and romantic education (Bond et al., 2009; Currin et al., 2017; Estes, 2016). This turn to media can expose students to inaccurate and stereotypical views on sexual and romantic acts, affecting practices and expectations (Comella, 2020; Currin et al., 2017; Currin et al., 2019; Estes, 2016; Mok, 1998; Paner, 2018; SIECUS, 2020). Past studies have looked at how this group, MAM, supplement their sexual and romantic education through media, but have drawn from primarily white participants with little data about other racial and ethnic groups such as Asian American and Pacific Islanders (AAPI) (Calzo et al., 2018; Currin et al., 2019; Dehann et al., 2012; Downing et al., 2017; Estes, 2016; Ocampo & Soodjinda, 2016). This gap leads to the imposing of past research on the AAPI MAM community. Furthermore, these studies tend to be more prescriptive in what is learned from the media and do not describe what the subjects have learned (Currin et al., 2017; Currin et al., 2019; Hall et al., 2016; Kosciw et al., 2018; Rose & Friedman, 2019; Smith, 2013; Steele, 1999). This study looks to fill these gaps in research by focusing on the AAPI MAM community of the USA and returning to the community to understand what they learned from the media they watched. It was found that AAPI MAM do supplement their sexual and romantic education through media and in so doing learned about racial, anatomical, and mechanical aspects of sex and romance. This study furthers our knowledge on how students, especially AAPI MAM, supplement their sexual and romantic education and allows practitioners to understand, design, and reflect on such curriculum.
Diksi dan Tema dalam Lagu Deny Caknan: Kartonyono Medot Janji dan Satru
Authors: Putri Shilfia Amalia
Published: April 2024

This study aims to analyze the use of diction and themes contained in Denny Caknan's Dangdut Song Lyrics. The method used is a qualitative descriptive method because the object is the text of the Song Lyrics. The research data is based on Kertonyono Medhot Janji and Satru song lyrics taken from the YouTube platform. Data analysis uses content analysis by comparing data with theories about stylistics, especially those related to diction. The results showed the presence of denotative, connotative, and polysemy diction in the two songs used as data.
Машинно-обучаемый потенциал для моделирования зарождения алмазной фазы в разориентированном бислойном графене
Authors: Буйлова М.А. , Ерохин С.В. , Сорокин П.Б.
Published: April 2024

В данной работе предложен машинно-обучаемый потенциал (МОП) на основе представления окружения через тензоры момента инерции для моделирования зарождения алмазной фазы в разупорядоченном двуслойном графене. МОП тренировался на наборе структур графена, 2D алмаза и их гидрированных модификаций, полученных расчетами с помощью теории функционала плотности. Обученный МОП точно воспроизводит энергии и силы этих структур, а также корректно описывает гидрирование двуслойного графена и образование межслойных связей. С помощью МОП был изучен рост алмазной фазы в разориентированном биграфене с разориентацией слоев на 5 градусов. Обнаружено, что энергия образования растет с числом атомов водорода, что указывает на нуклеацию водородного кластера на поверхности двуслойного графена. Гидрирование системы приводит к росту области кубического алмаза вплоть до упаковки AA', которая благоприятствует образованию лонсдейлита с поверхностью . Это позволяет сделать вывод об адекватности полученного потенциала.