bluuebunny/crossref_metadata_2025 huggingface dataset:
Basis for drug selectivity of plasmepsin IX and X inhibition for Plasmodium falciparum and vivax
Authors: Hodder Anthony N. ,   Janni Christensen1, Scally Stephen , Triglia Tony , Ngo Anna , Birkinshaw Richard W. , Bailey Brodie , Favuzza Paola , Dietrich Melanie H. , Tham Wai-Hong , Czabotar Peter E. , Lowes Kym , Guo Zhuyan , Murgolo Nicholas , Ruiz Manuel de Lera , McCauley John A. , Sleebs Brad E. , Olsen David , Cowman Alan F.
Published: September 2021

Plasmepsin IX (PMIX) and X (PMX) are aspartyl proteases of Plasmodium spp. that play essential roles in parasite egress, invasion and development. Consequently, they are important drug targets for Plasmodium falciparum and P. vivax. WM4 and WM382 are potent inhibitors of PMIX and PMX that block invasion of liver and blood stages and transmission to mosquitoes. WM4 specifically inhibits PMX whilst WM382 is a dual inhibitor of PMIX and PMX. To understand the function of PMIX and PMX proteases we identified new protein substrates in P. falciparum and together with detailed kinetic analyses and structural analyses identified key molecular interactions in the active site responsible for the specificity of WM4 and WM382 inhibition. The crystal structures of PMX apo enzyme and the protease/drug complexes of PMX/WM382 and PMX/WM4 for P. falciparum and P. vivax have been solved. We show PMIX and PMX have similar substrate selectivity, however, there are distinct differences for both peptide and full-length protein substrates through differences in localised 3-dimensional structures for the enzyme substrate-binding cleft and substrate interface. The differences in affinities of WM4 and WM382 binding for PMIX and PMX map to variations in surface interactions with each protease in the S' region of the active sites. Crystal structures of PMX reveal interactions and mechanistic detail on the selectivity of drug binding which will be important for further development of clinical candidates against these important molecular targets.
Unterhaltsam und/oder unverständlich?
Authors: Heiser Ines
Published: September 2021

Artikelbeginn:[English title and abstract below]
Seit der Jahrtausendwende wird in den Kommunikations- und Kulturwissenschaften ein sogenannter pictorial turn bzw. eine ›visuelle Wende‹ diskutiert (vgl. Mirzoeff 1998; ders. 1999; Mitchell 2008). Inzwischen präzisiert Bucher:
»Der grundlegende Wandel der Kommunikationsverhältnisse besteht nicht darin, dass zunehmend Abbildungen die Textkommunikation ergänzen oder einschränken [...]. Der grundlegende Wandel besteht darin, dass neue und neuartige Mischformen der verschiedensten Kommunikationsmodi und Kanäle entstanden sind, die man als multimodale Kommunikationsformen bezeichnen kann.« (Bucher 2011, S. 123)
Gudrun Marci-Boehncke macht als wesentliche Ursache dieser Hybridisierungen die durch das Internet, den »Ort [...] der Medien schlechthin«, in immer umfassenderer Weise gegebene Medienkonvergenz aus (Marci-Boehncke 2013, S. 507).
Entertaining and/or Incomprehensible?Fictionalisation and Factualisation Strategies in Comic Books about Ancient Rome
Recently, multimodal texts, i.e. texts using more than one mode to communicate with their readers, have become increasingly prominent in children’s literature. While the illustration of written texts has been a common long-time practice, the new multimodal books for children use images as an additional, original level of narrative. The general assumption in children’s literature studies is that it is easier for children to read a combination of text and images, as the images help them to understand the text. The analysis of three comic books on Roman history will show that, on the contrary, the process of understanding is actually more complex in the new multimodal texts for children: The pictorial narrative demands a more sophisticated kind of reading expertise. In addition, the task of decoding becomes more challenging when the narratives follow different intentions, which is often the case in contemporary comic books in which the pictorial narrative can be an ironic take on the written narrative.
Figures of Memory
Authors: Schulz Farriba
Published: September 2021

Artikelbeginn:[English title and abstract below]
Als global bekanntes Erinnerungsnarrativ nimmt Das Tagebuch der Anne Frank (erste deutsche Fassung 1950) einen bedeutenden Part in der Holocaust Education ein. Dabei beteiligt sich die grafische Adaption von Ari Folmans und David Polonskys Das Tagebuch der Anne Frank. Graphic Diary (2017) auf zweierlei Art am Fortschreiben des kulturellen Gedächtnisses; einerseits in seiner Geformtheit durch die Publikation selbst und darüber hinaus in seiner Organisiertheit aufgrund der institutionalisierten Kommunikation (vgl. Assmann 1988, S. 12).
Figures of MemoryAnne Frank’s Diary between Text and Image, Word and Symbol
Anne Frank’s Diary: The Graphic Interpretation by Ari Folman and David Polonsky (2017) is a recent addition to a sequence of editions that have shaped the perception of Anne Frank’s story. At the same time, the ethics and aesthetics of remembrance have been consistently discussed. These discussions have been fueled by discourses on memory as well as by the reimagination of the past by new generations. As Marianne Hirsch states »Postmemory’s connection to the past is [...] actually mediated not by recall but by imaginative investment, projection, and creation« (Hirsch 2012). Ari Folman and David Polonsky work with those imaginative approaches and reshape historical events on the visual and the verbal narrative levels. As with Waltz with Bashir (2009), on which Folman and Polonsky collaborated successfully as author and illustrator, Anne Frank’s Diary is also an extraordinary testimony of war based on extensive research. Intermedial references, such as historical photographs, documentaries and journal entries add authenticity to Anne Frank’s Diary: The Graphic Interpretation and lead the reader on a journey back in time. This article discusses the relationship between the visual representation of memory in the Diary and how it goes about narrating the story, and it examines this graphic novel’s potential for shaping and reshaping the reader’s perception of history.
Tannengrund und Wald
Authors: Stemmann Anna
Published: September 2021

Artikelbeginn:[English title and abstract below]
In Ludwig Tiecks Die Elfen (1812) und E.T.A. Hoffmanns Das fremde Kind (1817) nehmen Naturräume eine zentrale Position ein. Insbesondere der Wald ist als ein Kindheitsraum besetzt, der ambivalent konnotiert ist. Im Wald können sich die kindlichen Figuren fernab der Eltern autonom bewegen, dennoch geht diese Raumaneignung auch mit bedrohlichen Erfahrungen einher, die die aufstörenden Ablösungsprozesse in der Kindheit verdeutlichen.
 
Into the WoodsConstructions of Fragile Childhood in Ludwig Tieck’s Die Elfen and E.T.A . Hoffmann’s Das fremde Kind
In Die Elfen (1812) by Ludwig Tieck and Das fremde Kind (1817) by E.T.A. Hoffmann, natural spaces occupy a central position in terms of the spatial semantic field of the texts. As a narrative element, they fulfil complex functions that go beyond the mere spatial dimension. The forest, in particular, is rendered as a childhood space with ambivalent connotations and functions. Although the childlike figures can move autonomously within the forest – far away from their parents – this spatialisation is nevertheless accompanied by threatening experiences that reflect the disturbing process of detachment from childhood. This article examines the spatial construction of Hoffmann’s and Tieck’s texts by rereading both literary fairy tales from a topographical perspective in order, on the one hand, to trace the spatial semantic order (Yuri Lotman) and interstices (Michel Foucault) and, on the other, to discuss the associated notions of childhood. It also seeks to make recent German-language research on Romanticism, which has been informed by cultural studies, productive for children’s and young adult literature research. The idea of Romantic childhood as a utopia must, in the wake of the work of Detlef Kremer and Andreas Kilcher, be differentiated and brought into line with current research on Romanticism.
Schreiben lernen in der DDR
Authors: Stopka Katja
Published: September 2021

Artikelbeginn:[English title and abstract below]
An Kinder- und Jugendliteratur (KJL) herrschte in der DDR, die ja bekanntlich in vielen Bereichen durch Mangelwirtschaft gekennzeichnet war, tatsächlich kein Mangel. Sie wurde vom Staat gefördert und unterstützt, weil sie als wichtiges Instrument der sozialistischen Erziehung von Kindern und Jugendlichen galt (vgl. Lüdecke 2002, S. 434). Insofern besaß die KJL in der DDR einen vergleichsweise höheren gesellschaftlichen, politischen und künstlerischen Stellenwert als in der alten Bundesrepublik. Auch war die Grenze zwischen AutorInnen, die für eine erwachsene und eine kindliche bzw. jugendliche Leserschaft schrieben, nicht so strikt gezogen, wie man dies aus der Bundesrepublik kannte.
 
Learning to Write in the German Democratic Republic (GDR)Children’s and Young Adult Literature at the »Johannes R. Becher« Institute for Literature
There was no shortage of children's and young adult literature in the German Democratic Republic (GDR )—it was promoted and supported by the state because it was an important instrument in the socialist education of children and young adults. Relative to this high status, it is not surprising that many of the best-known authors of children's and young adult’s books in the GDR studied at the renowned »Johannes R. Becher« Institute for Literature in Leipzig. This first, and, for a long time, only institute for creative and literary writing in German speaking countries was founded in 1955 and mandated with the task of training socialist writers. It was closed after German reunification in 1990 but was incorporated in 1995 into the University of Leipzig as the Leipzig Institute for Literature. In this article, an overview of the structure, tasks and goals of the Johannes R. Becher Institute is given, and selected texts for children and young adults that were written by its students are examined. It also demonstrates how these texts can be socially and aesthetically classified within the framework and along the lines of the development of the socialist state.
»Jakob går over grensen« (1938)
Authors: Wassiltschenko Judith
Published: September 2021

Artikelbeginn:
Wenigen KJL- und ExilliteraturforscherInnen ist bekannt und gegenwärtig, dass der Arzt Dr. Max Hodann (1894–1946) im norwegischen Exil das belletristische Jugendbuch Jakob går over grensen veröffentlichte. Hodann-ForscherInnen mit einem Hintergrund in der Medizingeschichte, Pädagogik oder Sozialismusforschung, die von diesem Umstand zwar Notiz nahmen, konnten das Buch verständlicherweise jugendliteraturwissenschaftlich nicht angemessen behandeln, unterließen aber auch eine Einordnung in Hodanns Gesamtwerk. Mein Anliegen ist es daher, den Kinder- und JugendliteraturforscherInnen wie den Hodann-KennerInnen dieses Jugendbuch vorzustellen, es in den Exil(literatur)-Kontext einzuordnen und Bezüge und Unterschiede zu anderen KJL-Texten des Exils aufzuzeigen.
High-pressure single-crystal synchrotron X-ray diffraction study of lillianite
Authors: Zucchini Azzurra , Balić-Žunić Tonci , Collings Ines E. , Hanfland Michael , Comodi Paola
Published: September 2021

In this paper, high-pressure data from a synchrotron X-ray diffraction study on a lillianite (Pb3Bi2S6) single crystal up to ~21 GPa are presented. A phase transition from lillianite (space group Bbmm, LP lillianite) to the high-pressure form β-Pb3Bi2S6 (space group Pbnm, HP lillianite) was confirmed and bracketed between 4.90 and 4.92 GPa. The transition is reversible but of first-order with a hysteresis of ~2.8 GPa. It showed weak effects of pseudo-merohedral twinning that disappeared upon decompression, testifying to a full recovery of the single crystal of lillianite. This makes lillianite an interesting shape-memory material.

With a bulk modulus K4.9 = 78(3) GPa and K′ = 5.1(4), β-Pb3Bi2S6 is markedly less compressible than lillianite [K0 = 44(2) GPa, K′ = 7(1)]. Compressional anisotropy increases markedly in β-Pb3Bi2S6 with compressibility along the b axis [M0b = 130(6) GPa and Mb′ = 19(3) in lillianite, M4.9b = 145(4) GPa and Mb′ = 16.0(7) in β-Pb3Bi2S6] significantly larger than that along the other two axes [M0a = 118(5) GPa, Ma′ = 21(3), M0c = 139(12) GPa, and Mc′ = 31(10) in lillianite, M4.9a = 242(12) GPa, Ma′ = 8(1), M4.9c = 242(5) GPa, and Mc′ = 29(1) in β-Pb3Bi2S6].

The behavior of lillianite at high pressure is an interesting case study in relation to non-quenchable ultrahigh-pressure phases likely occurring in the inner Earth, like post-perovskite MgSiO3, the oxide homologue N = 1 of the lillianite series. The β-Pb3Bi2S6 structure, on the other hand, is the N = 3 homologue of the meneghinite series to which the higher-pressure modification of the post-perovskite structure also belongs (homologue N = 1). This makes the two forms of Pb3Bi2S6 potential equivalents of high- and ultrahigh-pressure Mg silicates that could occur both in the deep earth and in other rocky extrasolar planetary bodies.
Hydroxymcglassonite-(K), KSr4Si8O20(OH)·8H2O, the first Sr-bearing member of the apophyllite group, from the Wessels mine, Kalahari Manganese Field, South Africa
Authors: Yang Hexiong , Gu Xiangping , Scott Michael M.
Published: September 2021

A new mineral species, hydroxymcglassonite-(K), ideally KSr4Si8O20(OH)·8H2O, has been found in the Wessels mine, Kalahari Manganese Field, Northern Cape Province, South Africa. It is granular (<0.05 mm), associated with meieranite, sugilite, aegirine, pectolite, and yuzuxiangite. The mineral is colorless, transparent with a white streak and a vitreous luster. It is brittle and has a Mohs hardness of 4.5–5.0; cleavage is perfect on {001} and no parting or twinning was observed. The measured and calculated densities are 2.60(3) and 2.614 g/cm3, respectively. Optically, hydroxymcglassonite-(K) is uniaxial (+), with ω = 1.555(5), ε = 1.567(5) (white light), and absorption O > E. Hydroxymcglassonite-(K) is insoluble in water or hydrochloric acid. An electron microprobe analysis yielded an empirical formula (based on 13 non-H cations pfu) K1.01(Sr2.99Ca1.03)Σ4.02Si7.99O20(OH)·8H2O, which can be simplified to K(Sr,Ca)4Si8O20(OH)·8H2O.

Hydroxymcglassonite-(K) is tetragonal with space group P4/mnc and unit-cell parameters a = 9.0792(2), c = 16.1551(9) Å, V = 1331.70(9) Å3, and Z = 2. It is isostructural with hydroxyapophyllite-(K), KCa4Si8O20(OH)·8H2O, with Sr substituting for Ca. The crystal structure of hydroxy-mcglassonite-(K) is characterized by SiO4 tetrahedra sharing corners to form (Si8O20)8– sheets parallel to (001), which are connected by the K and B (= Sr + Ca) cations, as well as hydrogen bonding. The K cation is coordinated by eight H2O groups, and the average K–O distance of 2.941(3) Å is shorter than that of 2.950(3)–2.975(3) Å in hydroxyapophyllite-(K) or fluorapophyllite-(K). The B cation is sevenfold-coordinated (4O + 2H2O + OH), and the average B-O distance of 2.522(3) Å is noticeably longer than that of 2.422–2.435 Å in hydroxyapophyllite-(K) or fluorapophyllite-(K). The Raman spectra of hydroxymcglassonite-(K) and hydroxyapophyllite-(K) are very comparable, especially in the O-H stretching region. The discovery of hydroxymcglassonite-(K), the first Sr-bearing mineral of the apophyllite group, implies that more Sr-bearing members of the group may be found in nature or synthesized in laboratories, but the possibility for an incomplete solid solution between hydroxyapophyllite-(K) and hydroxymcglassonite-(K), due to the size difference between Sr2+ and Ca2+, cannot be ruled out.
Political Innovation as a Communicative Process: the receptivity of elites to innovations
Authors: Tereshchenko V. V.
Published: September 2021

The paper is dedicated to the analysis of political innovations in the context of the general theory of innovation. The author defines the main scientific approaches used in social sciences and humanities to innovations, identifies the political features of the introduction of innovations, and, based on the examination of the problems of innovations introduction from the standpoint of political science, analyzes the role of Russian elites in the development of modern Russia. The study reveals the content of the concepts of innovation in the political sphere and political innovation, which are not that much the innovations per se, but the political processes determined by these innovations, as well as the associated political decisions and applied innovative political technologies. The article reveals the role of Russian elites in the innovative development of Russia, analyzes the susceptibility of Russian elites to innovations on the basis of the Elite Quality Index, and shows their ability to implement policies for the innovative development of Russia.
“Smart watch” as a Factor for the Formation of Hybrid Doctor–Patient Communication
Authors: Kravchenko S. A. , Rakova K. V.
Published: September 2021

The relevance of the research derives from the necessity to analyze the influence of new non-human digital actants on the nature of doctor-patients communication. The authors prove that in modern society the digitalization of the healthcare system is proceeding at an accelerated pace and pushes individuals to monitor their health status regularly in background mode by using such digital actants as smartwatches with pre-installed medical applications. The active use of high-tech devices for self-diagnosis of health transforms the doctor-patient communication, making it hybrid and exerting ambivalent influence on the treatment process. On the one hand, individuals can collect health information continuously. However, on the other hand, the study reveals that smartwatches provide users with less accurate health information in comparison with the health information obtained via stationary medical equipment. The use of inaccurate information without the supervision of medical workers may lead to unforeseen consequences and health risks. The results of the content analysis of modern scientific research on the effectiveness of smart devices’ use in online health diagnostics indicate that formal and pragmatic trends take place in doctor-patient communication. In this regard, the authors prove that hybrid social communication in medicine needs a new vector of development in accordance with the principles of the proposed “humanistic turn”.
“Priority 2030” in the Context of the Development of Social Institutions in Russia
Authors: Stetsenko V. V.
Published: September 2021

The relevance of the article is associated by the author with the complex socioeconomic, political realities in which modern Russian society finds itself. The author turns to the category “social time” to characterize the changes in various spheres of society’s life. Focusing on such modern trends as digitalization, commercialization, atomization of society and the individual, the author turns to the category of “human capital”, designed to smooth out the indicated negative phenomena and restore the integrity of the social communications system. As a confirmation of the importance of human capital development at the state level, the article analyzes the fundamental doctrinal documents in the area under consideration. The author is elected for understanding the Priority-2030 program as an urgent initiative aimed, among other things, at building up human capital with the help of the education system. The author analyzes various authors’ positions in order to identify threats that impede the development of human capital within the education system. The methodological basis of the study was the methods of content analysis of the works of leading researchers, as well as discourse analysis of publications in the media and information resources. Analysis of the regulatory framework, as well as significant research platforms, allowed us to conclude that the principles of commercialization, digitalization, and bureaucratization prevail in the modern educational paradigm. At the same time, national priorities for building up human capital require a value-semantic foundation, which culture and educational activities are capable of providing.
Semantic and Style Concepts in Mass Communication Content
Authors: Kirichek P. N.
Published: September 2021

The article examines the semantic and style concepts of the functioning of mass communication in modern conditions, determines their role and significance for the transfer of public information from the communicator to the recipient. The author, analyzing the semantics and stylistics of media texts of an outstanding communicative personality (well-known journalist E.E. Kish), (1) traces gradual changes in the author’s worldview and the associated transformation of the nominal language and style; (2) identifies creative resources strengthening the intention of a journalistic work and improving the perceptual effect in “Author” – “Audience”, (3) comments on the positions established in the theory of the press on the relationship of ideas and style in publishing and (4) gives professional lessons in figurative and logical mastery novice journalists.
Prostitución femenina y género en el contexto colombiano: un estado del arte (2010-2019)
Authors: Celis Lozano Alejandra , Cristancho Gómez Sandra Milena , Valero Acevedo Nubia , Lafaurie Villamil María Mercedes
Published: September 2021

Introducción: desde el enfoque de género, la prostitución de las mujeres se explica como una expresión del modelo patriarcal. Este enfoque puede aportar elementos sustanciales para la comprensión y el abordaje a la prostitución femenina, de cara a la realidad colombiana, donde se carece de estudios documentales en esta línea conceptual. Método: se realizó un estado del arte de la investigación teórica y aplicada sobre la prostitución femenina, con lectura de género, en el periodo 2010-2019. Resultados: de los estudios analizados, varios situados en Bogotá, se ocupa especialmente la academia. Los autores coinciden en que la prostitución se deriva de la intersección entre desigualdades de género e injusticia social, y causa violencias de género y estigmatización. Políticas sociales para erradicarla, legalización y empoderamiento de las mujeres surgen como opciones para hacerle frente. Conclusión: para nutrir la política pública se requiere avanzar en la comprensión de los aspectos subjetivos implicados en este estilo de vida, profundizar en los discursos, construcciones y significados de género, e incluir la realidad de quienes están inmersas en la modalidad “prepago”.
Autoimmune hepatitis as the first manifestation of autoimmune polyendocrine syndrome type 1 in a 5-year-old girl
Authors: Yablokova E. A. , Rimskaya A. M. , Grintsevich Yu. P. , Vitebskaya A. V. , Borisova E. V. , Shavrov A. A. , Ibragimov S. I. , Orlova E. M. , Sozaeva L. S. , Grammatopulo M. I.
Published: September 2021

Autoimmune hepatitis is a chronic inflammatory liver disease of unknown etiology; the prevalence of juvenile autoimmune hepatitis is unknown. Autoimmune hepatitis occurs in 10–20% of patients with type 1 autoimmune polyendocrine syndrome, a rare (orphan) disease, which is characterized by a clinical triad in 70–100% of cases: chronic mucocutaneous candidiasis, hypopara thy roidismand adrenal insufficiency, as well as more 25 possible autoimmune endocrine and non-endocrine manifestations.

Thisstudy describes a case of a 5-year-old girl with autoimmune hepatitis as the first clinical manifestation of the disease. The symptoms of chronic mucocutaneous candidiasis enabled us to suggest and genetically confirm the diagnosis of autoimmune poly endocrine syndrome type 1 before the lesions of endocrine organs. The girl had nonsense mutations R257 * and p.Q94* of the AIRE gene in a compound heterozygous state. Later, there appeared another autoimmune disorder – common vitiligo.

Timelydiagnosisoftype1autoimmunepolyendocrinesyndromeinachildwiththefirstnon-endocrine autoimmune manifestation, initiation of therapy and further medical management made it possible to preventseve recomplications and improve the patient’s quality of life.
The role of the district pediatrician in the early diagnosis of speech developmental disorders in preschool children
Authors: Volgina S. Ya. , Ahmetova A. R. , Nikolaeva E. A. , Gamirova R. G. , Solovyeva N. A.
Published: September 2021

Speech and language are the most important means of communication between a child and the outer world. Currently in the Russian Federation there is no reliable data on the prevalence of speech and language disorders in children. According to foreign authors, speech disorders are diagnosed in 3,4–6,4% in the population of preschool children, and language disorders are diagnosed in 8–10% of cases. Early identification of the causes of speech and language development disorders in children is a complex interdisciplinary problem. The authors have developed an algorithm for diagnosing speech and language developmental disorders in preschool children, where the district pediatrician plays the leading role. It is district pediatrician who can assess the speed of the child’s speech skills development, based on age norms, analyze the history data, risk factors, carry out a physical examination of the child, develop an individual program for conducting basic laboratory and instrumental studies and consult specialists. Dynamic observation of this category of children is important.
The content of gas transmitters in umbilical cord blood and blood of newborns born to mothers with preeclampsia
Authors: Popova I. G. , Sitnikova O. G. , Nazarov S. B. , Kuzmenko G. N. , Klychevа M. M. , Kharlamova N. V. , Abramova I. V.
Published: September 2021

To assess endothelial function in the newborns born to mothers with preeclampsia and without preeclampsia the scientists assessed the content of nitricoxide and hydrogen sulfide in the umbilical and venous blood of these children. The main group consisted of 80 women with moderate preeclampsia and their80 newborns; the control group included 50 children born to women without preeclampsia. The authors studied the content of nitric oxide by determining the totalnitrates and nitrites (NOx), hydrogen sulfide in mixed cord blood collected within 30 minutes after delivery, and venous blood taken from newborns on the 1-3rd day of life. Umbilical cord blood demonstrated no significant differences in the content of NO xand hydrogen sulfide in newborns of the main and control groups. However, in general, the study of umbilical cord blood revealed a relationship between the concentration of hydrogen sulfide and the possibility of developing intraventricular hemorrhagein a newborn of the main and control groups. In the venous blood there was a significant increase in the content of NOx and hydrogen sulfide in newborns born to mothers with preeclampsia. It may cause vasodilation asa compensatory reaction of the body during the period of postnatal adaptation of the child’s body, aimed at life support.
LA INTEGRACIÓN AL ÁMBITO LABORAL DEL PEDAGOGO DE LA UNIVERSIDAD PANAMERICANA
Authors: Carreras Lomelí María Teresa
Published: September 2021

A 30 AÑOS DEL INICIO DE LA LICENCIATURA EN PEDAGOGÍA DE LA UNIVERSIdadPanamericana,* de la cual han egresado 27 generacionescon un total de 1520 exalumnos, la Facultad de Pedagogía llevaal cabo una reflexión sobre los logros alcanzados en estos años,así como los retos que enfrenta en un futuro inmediato.
LOS FINES DE LA EDUCACIÓN EN LA PEDAGOGÍA ESTRUCTURATIVA DE JOSÉ VASCONCELOS
Authors: Macías Barba María del Pilar
Published: September 2021

A un siglo de la fundación de la Secretaría de Educación Pública de México, es oportuno volver al planteamiento educativo de su fundador: José Vasconcelos, para identificar la congruencia y la grandeza de su propósito civilizador a partir de la instrucción, el trabajo, la cultura y el arte, un proyecto realmente educativo integral. El objetivo de este artículo es exponer el concepto de educación que subyace en la Pedagogía Estructurativa de José Vasconcelos y proponer cinco fines educativos que se desprenden de ella, y que guardan una relación armónica, jerárquica y sistémica. Esta propuesta es fruto de la selección, organización y el estudio de la obra escrita de Vasconcelos y principalmente del análisis del libro De Robinsón a Odiseo. Pedagogía Estructurativa.

El artículo está dividido en tres partes: la primera integra el concepto de educación; la segunda identifica los ámbitos o las dimensiones educables de la persona; y la tercera, y más relevante, propone la clasificación de los cinco objetivos educativos del pensamiento vasconcelista: educación física, profesional, intelectual, ética y estética. Se desea enfatizar que, como todo sistema, cada nivel educativo supone y se afianza en el nivel anterior y lo complementa, logrando un desarrollo individual trascendente, atendiendo también al bienestar espiritual y material de la colectividad. Lo anterior resalta el valor del ideario humanista que José Vasconcelos confirió a la Secretaría de Educación Pública y que estuvo detrás de su pasión por la regeneración espiritual de los mexicanos, para combatir «la ignorancia y la miseria, nuestros verdaderos enemigos» (Vasconcelos, 1920a, p. 52).
Antibiotic resistance genes in an urban stream before and after a state fair
Authors: O'Malley Kassidy , McNamara Patrick , McDonald Walter
Published: September 2021

The global spread of antibiotic resistance genes (ARGs) concomitant with a decrease in antibiotic effectiveness is a major public health issue. While research has demonstrated the impact of various urban sources, such as wastewater treatment plant (WWTP) effluent, stormwater runoff, and industrial discharge on ARG abundance in receiving waters, the impact of short-term gatherings such as state fairs is not comprehensively understood. The objective of this research was to explore the impact of a 2-week Wisconsin State Fair gathering – over 1.1 million visitors and 7,100 farm animals – on the abundance of the ARG blaTEM, the integrase of the class 1 integron (intI1), a marker for horizontal gene transfer, and the 16S rRNA gene, a marker for total biomass, in an urban stream receiving runoff from the state fair. Stream samples downstream of the state fair were taken before and after the event and quantified via a droplet digital polymerase chain reaction. The absolute abundance of all genes was significantly higher (p<0.05) following the event. This research showcases the prevalence and persistence of ARG contamination in an urban stream before and after a state fair gathering, suggesting that short-term events can be a significant source of ARGs into the environment.
ESPAÇOS ABERTOS DO HOSPITAL ESPÍRITA DE PORTO ALEGRE
Authors: Bagnati Mariana Moura , Fedrizzi Beatriz Maria
Published: September 2021

No artigo é examinada a temática do jardim de cura como um recurso na arquitetura da paisagem, para o suporte à terapêutica tradicionalmente aplicada à reabilitação de dependentes químicos, assunto ainda pouco disseminado no país, e na América Latina. Mas será que o potencial terapêutico da natureza é explorado de maneira adequada para atuar como parte ativa na reabilitação de indivíduos adictos? A partir do estudo de caso desenvolvido junto ao Hospital Espírita de Porto Alegre, nesta pesquisa procura-se evidenciar a matéria do jardim de cura, e divulgá-la como uma ferramenta no planejamento dos espaços abertos para o restabelecimento da saúde humana. O artigo é uma pesquisa qualitativa em que são empregadas as técnicas metodológicas survey e observação. Além disso, está assente em relevantes referências bibliográficas que permeiam o tema, no exame de normativas que regulamentam os espaços abertos de instituições desta especialidade, na apresentação de notáveis exemplares de jardins de cura, e na abordagem de teoria que apoia a relação entre natureza e bem-estar. Dentre os desfechos do estudo, é sublinhada a necessidade de reformulação dos regulamentos que normatizam os espaços abertos de entidades dedicadas à reabilitação de adictos.
Model of the Process of Conducting Computer Attacks Using Special Information Influences
Authors:   Russian Defense Ministry, Kondakov Sergey , Rud Ilya ,   Russian Defense Ministry
Published: September 2021

Purpose of work: development of a model of the process of conducting a computer attack. Research method: theory of complex systems, comparative analysis within the framework of system analysis and synthesis. Result: it is shown that the application of the proposed model of the process of conducting computer attacks allows you to fully describe the process, taking into account its inherent features and characteristics. The use in the model of information from the MITRE ATTACK database of Mitre, which contains a description of the tactics, techniques and methods used by cybercriminals, allows you to reduce the level of abstraction and describe specific scenarios for conducting complex targeted computer attacks with the maximum approximation to practice. The developed model is supposed to be used to form scenarios of computer attacks when assessing the security of information systems.
Development of a Research Apparatus for Assessing the Effectiveness of Measures to Ensure the Protection of Personal Data
Authors:   Russian Defense Ministry, Kondakov Sergey , Chudin Kirill ,   Russian Defense Ministry
Published: September 2021

The purpose of the article: to investigate the prerequisites for the development of a methodological apparatus for ensuring the protection of personal data in the activities of the personnel body of the state secret protection service. Research method. system analysis, synergetics. The result: the procedure for the formation of the appropriate research environment is formulated, the stages of formation of the concept of building a research apparatus for assessing the effectiveness of measures to ensure the protection of personal data in the activities of the personnel body of the state secret protection service are given. The concept of building a research apparatus for assessing the characteristics of measures to ensure the protection of personal data in the activities of the personnel body of the state secret protection service is proposed, which allows forming an environment for an adequate assessment of the effectiveness of such measures, as well as determining a set of hypotheses and analogies necessary for setting and solving the problem of increasing the adequacy of assessing the effectiveness of measures to ensure the protection of personal data in the activities of the personnel body of the state secret protection service as a task of developing mathematical models of the characteristics of threats to the security of personal data and the processes of their protection.
Research of the Passive Information Protection Device in the Acoustoelectric Leakage Channels Using Matlab Environment
Authors:   National Research University of Electronic Technology, Horev Anatoly , Lukmanova Oksana ,   National Research University of Electronic Technology, Surovenkov Dmitry ,   Russian Defense Ministry
Published: September 2021

Purpose: design of the passive device of the speech information protection from acoustoelectric leakage channels and study of the characteristics of protection device using a virtual laboratory bench developed in the Matlab environment. Methods: mathematical modeling using Matlab environment. Practical relevance: designed in the Matlab modeling environment: an equivalent circuit of the telephone set, which makes it possible to simulate acoustoelectric information leakage channels, schematic diagrams of passive protection devices for telephone sets that implement protection methods: limiting low-amplitude signals, filtering high-frequency injection signals and disabling acoustoelectric transducers, a virtual laboratory stand for research of the characteristics of protective device. Using a virtual laboratory stand, the main characteristics of the developed protection devices were studied and their performance was assessed when connected to the telephone network.
Development of a Prototype of a Hardware and Software Device for Panoramic Viewing for Security Systems and Situational Awareness of an Unmanned Vehicle
Authors:   Russian Defense Ministry, Vashchenko Andrey , Gavrilov Dmitry ,   Lebedev Institute of Precision Mechanics and Computer Engineering with Russian Academy of Science,   Moscow Institute of Physics and Technology, Lapushkin Andrey ,   Moscow Institute of Physics and Technology
Published: September 2021

Purpose of the article: development and creation of a prototype of a panoramic viewing device for an unmanned vehicle that allows recording the surrounding stop as close as possible to the capabilities of human vision, as well as the development of a set of measures to ensure situational awareness of autonomous devices. Method used: The development of the basic basic form was carried out using the SolidWorks software package. The software part of the prototype is made in the form of a desktop application deployed on a computer running Ubuntu 18.04. Mathematical formalization and calculation of distortion parameters are performed. Results: A conceptual study of the design of the “super camera” was carried out, the calculation of distortion compensation, including tangential and radial distortions, was carried out, the physical implementation of the prototype of the panoramic viewing device was presented.
Advances in Nanocarriers for Drug Delivery in Dental Therapies
Authors:   Product Development Department, Cure Pharmaceutical Corporation, Los Angeles, CA 90025, USA, Patel Bhaumik , Kamineni Yeshwanthi ,   Talasila Super Speciality Dental Hospital, Visakhapatnam, Andhra Pradesh, 530026, India, Gorityala Shashank ,   Department of Bioanalytical Chemistry, Covance Laboratories, Madison, WI, 53704, USA, Bindu M Hima ,   Department of Pharmaceutical Analysis, School of Pharmacy, Anurag Group of Institutions, Ghatkesar, 500088, Telangana, India
Published: September 2021

Dental caries are one of the major causes of oral degeneration diseases. In order to treat dental-related diseases, it is often challenging and expensive. Recent literature has reported many advances in designing delivery systems utilizing polymers and novel biomaterials. Polymers play an important role in designing many nanoformulations like liposomes, polymeric micelles, polymeric nanoparticles, carbon-based nanoparticles, nano-hydroxyapatite, iron oxide, zirconia, silica, and silver nanoparticles were used to treat oral complications of the oral cavity including dental caries, periodontal disease, and oral cancer. The present review focus on the importance of novel biodegradable polymers like poly (D, L-Lactide acid), PLLA (poly-L-lactide), PDLA (poly-D- lactide), PLGA that is poly (D, L Lactide-co-glycolide), cellulose acetate phthalate, and Chitosan, etc used to design site-specific delivery and controlled drug delivery to treat dental diseases. Moreover, research development in this area will raise opportunities for the dentist, researchers, and pharmaceutical scientists to fabricate an ideal drug delivery system.
The Effect of Noninvasive Telemonitoring for Chronic Heart Failure on Health Care Utilization: Systematic Review
Authors: Auener Stefan L , Remers Toine E P , van Dulmen Simone A , Westert Gert P , Kool Rudolf B , Jeurissen Patrick P T
Published: September 2021

Background

Chronic heart failure accounts for approximately 1%-2% of health care expenditures in most developed countries. These costs are primarily driven by hospitalizations and comorbidities. Telemonitoring has been proposed to reduce the number of hospitalizations and decrease the cost of treatment for patients with heart failure. However, the effects of telemonitoring on health care utilization remain unclear.

Objective

This systematic review aims to study the effect of telemonitoring programs on health care utilization and costs in patients with chronic heart failure. We assess the effect of telemonitoring on hospitalizations, emergency department visits, length of stay, hospital days, nonemergency department visits, and health care costs.

Methods

We searched PubMed, Embase, and Web of Science for randomized controlled trials and nonrandomized studies on noninvasive telemonitoring and health care utilization. We included studies published between January 2010 and August 2020. For each study, we extracted the reported data on the effect of telemonitoring on health care utilization. We used P<.05 and CIs not including 1.00 to determine whether the effect was statistically significant.

Results

We included 16 randomized controlled trials and 13 nonrandomized studies. Inclusion criteria, population characteristics, and outcome measures differed among the included studies. Most studies showed no effect of telemonitoring on health care utilization. The number of hospitalizations was significantly reduced in 38% (9/24) of studies, whereas emergency department visits were reduced in 13% (1/8) of studies. An increase in nonemergency department visits (6/9, 67% of studies) was reported. Health care costs showed ambiguous results, with 3 studies reporting an increase in health care costs, 3 studies reporting a reduction, and 4 studies reporting no significant differences. Health care cost reductions were realized through a reduction in hospitalizations, whereas increases were caused by the high costs of the telemonitoring program or increased health care utilization.

Conclusions

Most telemonitoring programs do not show clear effects on health care utilization measures, except for an increase in nonemergency outpatient department visits. This may be an unwarranted side effect rather than a prerequisite for effective telemonitoring. The consequences of telemonitoring on nonemergency outpatient visits should receive more attention from regulators, payers, and providers. This review further demonstrates the high clinical and methodological heterogeneity of telemonitoring programs. This should be taken into account in future meta-analyses aimed at identifying the effective components of telemonitoring programs.
The Effect of Noninvasive Telemonitoring for Chronic Heart Failure on Health Care Utilization: Systematic Review (Preprint)
Authors: Auener Stefan L , Remers Toine E P , van Dulmen Simone A , Westert Gert P , Kool Rudolf B , Jeurissen Patrick P T
Published: September 2021

BACKGROUND

Chronic heart failure accounts for approximately 1%-2% of health care expenditures in most developed countries. These costs are primarily driven by hospitalizations and comorbidities. Telemonitoring has been proposed to reduce the number of hospitalizations and decrease the cost of treatment for patients with heart failure. However, the effects of telemonitoring on health care utilization remain unclear.

OBJECTIVE

This systematic review aims to study the effect of telemonitoring programs on health care utilization and costs in patients with chronic heart failure. We assess the effect of telemonitoring on hospitalizations, emergency department visits, length of stay, hospital days, nonemergency department visits, and health care costs.

METHODS

We searched PubMed, Embase, and Web of Science for randomized controlled trials and nonrandomized studies on noninvasive telemonitoring and health care utilization. We included studies published between January 2010 and August 2020. For each study, we extracted the reported data on the effect of telemonitoring on health care utilization. We used P<.05 and CIs not including 1.00 to determine whether the effect was statistically significant.

RESULTS

We included 16 randomized controlled trials and 13 nonrandomized studies. Inclusion criteria, population characteristics, and outcome measures differed among the included studies. Most studies showed no effect of telemonitoring on health care utilization. The number of hospitalizations was significantly reduced in 38% (9/24) of studies, whereas emergency department visits were reduced in 13% (1/8) of studies. An increase in nonemergency department visits (6/9, 67% of studies) was reported. Health care costs showed ambiguous results, with 3 studies reporting an increase in health care costs, 3 studies reporting a reduction, and 4 studies reporting no significant differences. Health care cost reductions were realized through a reduction in hospitalizations, whereas increases were caused by the high costs of the telemonitoring program or increased health care utilization.

CONCLUSIONS

Most telemonitoring programs do not show clear effects on health care utilization measures, except for an increase in nonemergency outpatient department visits. This may be an unwarranted side effect rather than a prerequisite for effective telemonitoring. The consequences of telemonitoring on nonemergency outpatient visits should receive more attention from regulators, payers, and providers. This review further demonstrates the high clinical and methodological heterogeneity of telemonitoring programs. This should be taken into account in future meta-analyses aimed at identifying the effective components of telemonitoring programs.
The Psychological Experience of Frontline Perioperative Health Care Staff in Responding to COVID-19: Qualitative Study (Preprint)
Authors: Withiel Toni , Barson Elizabeth , Ng Irene , Segal Reny , Williams Daryl Lindsay Goulding , Krieser Roni Benjamin , Lee Keat , Mezzavia Paul Mario , Sindoni Teresa , Chen Yinwei , Fisher Caroline Anne
Published: September 2021

BACKGROUND

The rapid spread of the novel coronavirus (COVID-19) has presented immeasurable challenges to health care workers who remain at the frontline of the pandemic. A rapidly evolving body of literature has quantitatively demonstrated significant psychological impacts of the pandemic on health care workers. However, little is known about the lived experience of the pandemic for frontline medical staff.

OBJECTIVE

This study aimed to explore the qualitative experience of perioperative staff from a large trauma hospital in Melbourne, Australia.

METHODS

Inductive thematic analysis using a critical realist approach was used to analyze data from 9 semistructured interviews.

RESULTS

Four key themes were identified. Hospital preparedness related to the perceived readiness of the hospital to respond to the pandemic and encompassed key subthemes around communication of policy changes, team leadership, and resource availability. Perceptions of readiness contributed to the perceived psychological impacts of the pandemic, which were highly varied and ranged from anger to anxiety. A number of coping strategies were identified in response to psychological impacts which incorporated both internal and external coping mechanisms. Finally, adaptation with time reflected change and growth over time, and encompassed all other themes.

CONCLUSIONS

While frontline staff and hospitals have rapidly marshalled a response to managing the virus, relatively less consideration was seen regarding staff mental health in our study. Findings highlight the vulnerability of health care workers in response to the pandemic and reinforce the need for a coordinated approach to managing mental health.