bluuebunny/crossref_metadata_2025 huggingface dataset:
A Field in Flux: The Intriguing Past and the Promising Future of Audience Analysis
Authors: Das Ranjana
Published: December 2018

Throughout its illustrious history, the journal Television and New Media has made recurrent editorial decisions to keep audiences within the frame of studying television and new media, returning, time and again, to people’s everyday sense-making of the media as both text and object, as Roger Silverstone expressed it, and publishing audience research in ways that articulated its relevance to a range of sectors in communication studies. This special issue, quite fittingly for this journal, brings together a series of articles, which are written by a set of communication scholars who frequently delve into the messy world that is empirical audience research, but who reflect, here, on the very state and status of the field as it navigates a moment in communication studies scholarship where datafication challenges, perplexes, frustrates, enthuses, and, increasingly, engages in some way or another most communication scholars one meets. In this short editorial, I look at the ways in which these articles approach the field of audience research itself, at a point in time when datafication poses an array of new challenges to mediated societies.
Relationships Between Cognitive Dysfunction and Health-Related Quality of Life Among Older Persons in Taiwan: A Nationwide Population-Based Survey
Authors: Liu Hsin-Yun , Tsai Wen-Che , Chiu Ming-Jang , Tang Li-Yu , Lee Huey-Jane , Shyu Yea-Ing L. , Wang Woan-Shyuan
Published: December 2018

Background:

To examine the relationships between cognitive dysfunction status and quality of life.

Methods:

Secondary analysis of a nationwide population-based survey (≥65 years) in Taiwan. The 5-dimension EuroQoL questionnaire (EQ-5D) was completed by 10 013 participants.

Results:

Participants with mild cognitive impairment (MCI; odds ratio = 4.88), very mild dementia (VMD; 7.96), or dementia (32.85) were more likely than those with normal cognition to report self-care problems. Participants with MCI (3.86), VMD (9.26), or dementia (31.61) were more likely to have usual-activity problems, and those with MCI (3.04), VMD (3.82), or dementia (9.23) were more likely to have mobility problems. Participants with MCI (2.10 and 2.14), VMD (2.77 and 2.18), or dementia (3.04 and 3.02) were more likely to report pain/discomfort and anxiety/depression.

Conclusion:

Dementia was negatively associated with EQ-5D, especially self-care, usual activities, and mobility. Mild cognitive impairment or VMD was also negatively associated, with VMD more negatively associated. Developing interventions for patients with specific cognitive dysfunctions is critical.
KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2
Authors: Wang Binshuai , Liu Mingyuan , Song Yimeng , Li Changying , Zhang Shudong , Ma Lulin
Published: December 2018

KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown. This study aimed to explore the role of KLF2 in the migration and invasion of PCa cells. The expression of KLF2 was measured by immunohistochemistry in PCa tissues and in paired non-tumor tissues. KLF2 and MMP2 expression in cells was measured by Western blot and RT-qPCR. Adenoviruses and siRNAs were used in cell function tests to investigate the role of KLF2 in regulating MMP2. Interactions between KLF2 and MMP2 were analyzed by a luciferase activity assay. The present study, for the first time, identified that KLF2 was downregulated both in PCa clinical tissue samples and in cancer cell lines. The overexpression of KLF2 inhibited the migration and invasion of PCa cells via the suppression of MMP2.This study demonstrates that KLF2 might act as a tumor suppressor gene in PCa and that the pharmaceutical upregulation of KLF2 may be a potential approach for treatment.
Single Process Production of 3D Nonwoven Shell Structures: Part 2 — CFD Modeling of Thermal Bonding Process
Authors: Gong R.H. , Dong Z. , Porat I.
Published: December 2018

The design and modeling of a thermal bonding process for the consolidation of 3D nonwoven shell structures is described. The process is modeled using CFD technology to optimize the temperature, velocity and pressure distribution of the hot air flow around the 3D structure. The relationships between the temperature distribution and various process parameters are investigated. The modeling results are experimentally evaluated on a laboratory prototype.
Role of Fiber Finish in the Conversion of Fiber to Nonwovens — Part 1: Need for an Unconventional Method to Evaluate Finish Performance as a Mechanical Process Aid
Authors: Seyam Abdelfattah M.
Published: December 2018

The processing of fibers in a free, non-bound state gives rise to a range of frictional behavior for a given process. The basic laws of fiber friction are reviewed. The finish treatment to the fibers mainly act as a lubricant and anti static agent. A critical review of the requirements of the finish treatment and the methods used to evaluate fiber friction and static charge generation are presented. The requirements of the finish treatment with respect to carding and needlepunching are also discussed. The ineffectiveness of conventional methods to evaluate performance of finish in such process and the need to measure performance of finish and optimize it for each of these processes is highlighted. Methods to evaluate the finish performance in carding and needlepunching will be presented in Parts 2 and 3.
Fiber Formation during Melt Blowing
Authors: Bresee Randall R. , Ko Wen-Chien
Published: December 2018

Experimental measurements are presented to provide phenomenological insight into the commercial melt blowing process. In particular, we discuss the following experimental measurements obtained at various die-collector locations: fiber diameter, fiber velocity, air velocity, fiber acceleration, fiber entanglement, fiber temperature, birefringence, wide-angle x-ray diffraction and small-angle x-ray scattering. Our discussion focuses on how these measurements provide insight into fiber formation during melt blowing.
In-Plane Liquid Distribution in Nonwoven Fabrics: Part 2 — Simulation
Authors: Kim H. S. , Pourdeyhimi B.
Published: December 2018

In a recent paper, we reported on a new absorbency testing system that measures in-plane fluid flow, absorbency and pore volume distribution [8]. The importance of fiber orientation characteristic in nonwovens, as it directly influences the in-plane fluid flow in nonwovens was explored.

In this paper, we present a framework for the prediction of in-plane wicking in nonwovens. This paper describes the underlying foundation for the simulation of in-plane wicking and reports on preliminary comparisons between simulation and experimental data.
Computational Modeling of Protective Clothing
Authors: Barry James J. , Engineer Principal , Hill Roger W.
Published: December 2018

Models based on computational fluid dynamics (CFD) have been developed to predict the performance of chemical and steam/fire protective clothing. The software computes the diffusive and convective transport of heat and gases/vapors; capillary transport of liquids; vapor and liquid sorption phenomena and phase change; and the variable properties of the various clothing layers. It can also model the effects of sweating and humidity transport to help assess the thermal stress imposed on the wearer of the clothing. Specialized geometry/grid representations of clothed humans have been created for performing two- and three-dimensional simulations. Comparisons with experimental data show good agreement in predicting the effects of fiber swell due to transients in humidity, and the models have been used to predict the sensitivity of clothing performance to material properties such as permeability under varying environmental conditions. Applications of the models include analysis of chemical protective garment design for military and emergency response personnel, comparisons of thermally protective materials for steam or fire protection, and evaluation of clothing test data.
Particle Containment and Immobilization in Roll Good Materials
Authors: Baer Samuel C.
Published: December 2018

Integration of functional particles such as superabsorbent or zeolite powders into a roll good provides a way of imparting a virtually unlimited range of desired properties to a two-dimensional structure. This paper examines and compares the efficiency of various powder containment methods and their effect on properties such as absorbent capacity and fluid permeability. Methods of particle containment and/or immobilization include particle-to-particle adhesion, particle-to-fiber adhesion, and powder entrapment between bonded fibers.
Meltblown Structures Formed by Robotic and Meltblowing Integrated System: Interaction between the Fiber Diameter, Orientation Distribution and Pore Diameter of Simulated Networks and Real Webs
Authors: Velu Yogeshwar K. , Ghosh Tushar K. , Seyam Abdelfattah M.
Published: December 2018

Meltblown nonwovens have been produced as 2D web structures for a variety of end uses. Investigation into the development of 3D structures has resulted in a parametric evaluation of the process and its effects on the structural properties of the webs (fiber diameter, fiber orientation, and pore size distributions). The interrelationships between these structural parameters have been explored and a statistical model developed. SAS was used to develop the correlations between the structural parameters of the web. The pore diameter is found to be directly proportional to the fiber diameter and inversely related to the web anisotropy parameter. The relationship that was established for the 2D webs correlates to the relationship developed for the 3D web structures.
Cutting Costs Prior to ‘Cutting Metal’ in the Nonwovens Industry
Authors: Mukhopadhyay A. , Kelecy F. J.
Published: December 2018

As the North American nonwovens market has matured over the last ten years, computer-aided design, engineering and flow analysis have established themselves as effective engineering tools to complement and optimize traditional design, analysis and testing. This has lead to significant cost and time savings in the product life cycle. More specifically, these tools mainly impact pre-market activities, thus they reduce time-to-market and overall development expense.

This paper demonstrates the successful use of computational fluid dynamics (CFD) tools to achieve cost-effective design analysis and optimization. Examples of airflow delivery systems (fan/blower design and jets/diffusers in spun bond process) and analysis of filter performance are shown
Study on a Novel Material Technology for Chemical/Biological Protection
Authors: Hao Xinmin , Guo Yuhai
Published: December 2018

A novel chemical/biological (CB) protective material was studied in this paper. The material was designed to provide protective properties and satisfactory wearing comfort. In the fabric construction, a PET fabric was laminated with modified PTFE membrane by paste dot coating, and then coated by PU solution in a direct process. Finally, it was laminated with active carbon felt. The modified PTFE membrane completely prevents permeation of the mustard liquid and biological warfare agent, any residuals penetrating the PU will be absorbed by active carbon felt. Furthermore, the CB protective material can provide satisfactory wearing comfort.
Influence of Processing Conditions on Melt Blown Web Structure. Part III — Water Quench
Authors: Bresee Randall R. , Qureshi Uzair A.
Published: December 2018

The overall goal of our recent research has been to quantitatively measure the influence of commercial processing variables on the structure of polypropylene melt blown webs. In this paper, we applied a cool water quench spray to fibers to increase their thermal quenching rate. Then, we collected webs and measured single fiber diameter, shot content, fiber bundle size, basis weight uniformity and pore structure. The structure of webs produced with and without quenching was compared to access the influence of quenching on webs.
Fiberglass Surface and Its Electrokinetic Properties
Authors: Dong Daojie
Published: December 2018

The surface charge of fiberglass is an important variable for fiber dispersion and web formation in a wet-laid process. This paper presents an overview of the glass surface electrokinetic properties as well as their applications for improving the quality of wet-laid nonwovens through good fiber dispersion and uniform web formation. The paper addresses the basic concepts used in electrokinetic characterization of glass surface and briefly discusses the available techniques for zeta potential measurement.
Using Various Nonlinear Response Surfaces for Mathematical Description of the Type of Combined Toxicity
Authors: Varaksin Anatoly N. , Panov Vladimir G. , Katsnelson Boris A. , Minigalieva Ilzira A.
Published: December 2018

The article considers the problem of characterizing the type of combined action produced by a mixture of toxic substances with the help of nonlinear response functions. Most attention is given to second-order models: the linear model with a cross-term and the quadratic model. General propositions are formulated based on the data on combined toxicity patterns previously obtained by the Ekaterinburg nanotoxicology team in animal experiments and analyzed with the help of the linear model with a cross-term. It is shown now that the quadratic model features these general characteristics in full measure, but interpretation of combined toxicity types based on isobolograms obtained by the quadratic model is more difficult. This suggests that where both models ensure a comparable quality of combined toxicity type identification, it would be enough to use the linear model with a cross-term.
The neglected element of hand hygiene - significance of hand drying, efficiency of different methods and clinical implication: A review
Authors: Gammon John , Hunt Julian
Published: December 2018

Hand hygiene is a fundamental strategy for controlling the spread of infection. Careful hand drying is integral to the process of hand hygiene, which aims to optimise the removal of potentially pathogenic microorganisms. Ineffective hand drying results in wet hands that are an infection risk increasing the potential for cross-infection, occupational contact dermatitis for healthcare practitioners, harm to patients and environmental contamination.

Evidence indicates that there has been limited research regarding the significance of hand drying and the efficacy and clinical impact of different drying methods. The purpose of this review paper was to scope and evaluate the existing literature pertaining to hand drying; to examine the clinical consequences associated with wet hands for patients, healthcare practitioners and the clinical environment; to assess the efficacy of different drying methods; to consider the impact on patient safety; and to progress the research, debate and practice relating to hand drying. The methodological framework applied in this review was that of Arksey and O’Malley (2007). Twenty-one papers identified from 112 abstracts screened were included in the review. Analysis identified three primary themes emerging from the literature: (1) efficacy of hand drying methods; (2) drying method and microbial translocation, dispersion and environmental contamination; and (3) drying methods and environmental sustainability. This review highlights the equal importance of hand drying in the process of hand hygiene and suggests that the efficacy of hand drying is a critical factor in the prevention of the transfer of microorganisms to the environment, and from person to person following hand washing. In conclusion, this paper argues that greater attention needs to be given to hand drying in terms of practice, policy and research and its importance in clinical settings given greater focus.
Bundles of trouble: Can competition law adapt to digital pricing innovation?
Authors: Howell Bronwyn E. , Potgieter Petrus H.
Published: December 2018

The burgeoning digital economy is characterized by bundled offers of goods and services, many with near-zero marginal cost, in highly concentrated markets often exhibiting competition ‘for the market’ and ‘winner-takes-all’ outcomes. Acceptable competitive behaviour in these markets likely differs substantially from that in markets for goods with standard economic characteristics. The suitability of current tools used to specify and enforce competition laws for governing commercial activity in a digital economy dominated by bundled offers is questionable. Classical market analysis focuses narrowly on individual product markets. In bundle product markets, quantitative econometric analysis becomes computationally intractable as the own- and cross-elasticities increase exponentially with the number of products in the bundle and providers in the market. Furthermore, classic econometric analysis cannot inform decisions in markets where bundles are yet to be offered. Simulation and numerical analysis of hypothetical scenarios under different consumer preferences and firm strategic choices offers another means of evaluating effects of intervention in specific circumstances. We illustrate using a model based on the (declined) proposed New Zealand merger between Sky Television and Vodafone and make recommendations for both theory and practice as to how simulation analysis can be used to complement more conventional competition analyses.
From Good News for Modern Man to Good News Bible: Origins and Early Issues
Authors: Stine Philip C.
Published: December 2018

This article draws on interviews with key personnel and archival material to offer insight into the translation of and publishing issues in the Good News Bible. The New Testament was published by the American Bible Society (ABS) in 1966 as Good News for Modern Man: The New Testament in Today’s English. The success of the translation led to a decision to undertake the Old Testament. The ABS translation committee and board reviewed the OT drafts extensively, a process which often put them in conflict with the translators. The article will discuss key decisions taken by ABS. Some, for example the cover and artwork of the New Testament, were successful. Others, for example the marketing plan for the Old Testament, proved to be less so.
Who benefits and how? Public expectations of public benefits from data-intensive health research
Authors: Aitken Mhairi , Porteous Carol , Creamer Emily , Cunningham-Burley Sarah
Published: December 2018

The digitization of society and academic research endeavours have led to an explosion of interest in the potential uses of population data in research. Alongside this, increasing attention is focussing on the conditions necessary for maintaining a social license for research practices. Previous research has pointed to the importance of demonstrating “public benefits” from research for maintaining public support, yet there has been very little consideration of what the term “public benefits” means or what public expectations of “public benefits” are. In order to address this pressing issue a series of deliberative workshops with members of the public were held across Scotland in May and June 2017. The workshops aimed to engage a cross-section of the Scottish population in in-depth discussions of the ways that the public – or publics – might benefit from data-intensive health research. The findings reported here discuss workshop participants’ understandings and expectations of health research; who they considered to be “the public” that should benefit from health research and; in what ways they felt “the public” should benefit. Workshop participants’ preference was clearly for the widest possible public benefit to be felt by all, but they also acknowledged the value in research aiming to primarily benefit vulnerable groups within society. A key focus of discussions was the extent to which workshop participants were confident that potential public benefits would be realised. A crucial consideration then is the extent to which mechanisms and political support are in place to realise and maximise the public benefits of data-intensive health research.
Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results
Authors: Berner Juan Enrique , Keckes Dejan , Pywell Matthew , Dheansa Baljit
Published: December 2018

Background:

Bromelain-based enzymatic debridement with Nexobrid® (Mediwound) is an alternative to traditional surgical tangential excision of deep dermal and full thickness burns. Early literature suggests that Nexobrid debridement could reduce the number of operations, infection rates, inpatient stay and the necessity for skin grafting to wounds by preserving viable tissue. To our knowledge there are no previous studies reporting the use of NexoBrid for treating burns in patients with established diabetic foot disease.

Case presentation:

We conducted a retrospective case series and identified four patients with diabetic foot burns that were treated with Nexobrid® debridement. All of these patients developed further eschar and deepening of their wounds a few days after NexoBrid was applied, requiring further surgery and skin grafting.

Conclusions:

We would recommend judicious use of this new product in patients with diabetic foot wounds.
Purine and purinergic receptors
Authors: Burnstock Geoffrey
Published: December 2018

Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ectonucleotidases. Four subtypes are recognised, A1, A2A, A2B and A3 receptors. P2 receptors are activated by purine and by pyrimidine nucleotides. P2X receptors are ligand-gated ion channel receptors (seven subunits (P2X1-7)), which form trimers as both homomultimers and heteromultimers. P2Y receptors are G protein-coupled receptors (eight subtypes (P2Y1/2/4/6/11/12/13/14)). There is both purinergic short-term signalling and long-term (trophic) signalling. The cloning of P2X-like receptors in primitive invertebrates suggests that adenosine 5′-triphosphate is an early evolutionary extracellular signalling molecule. Selective purinoceptor agonists and antagonists with therapeutic potential have been developed for a wide range of diseases, including thrombosis and stroke, dry eye, atherosclerosis, kidney failure, osteoporosis, bladder incontinence, colitis, neurodegenerative diseases and cancer.
Multispectral, multiazimuth, and multioffset coherence attribute applications
Authors: Chopra Satinder , Marfurt Kurt J.
Published: December 2018

The coherence attribute computation is typically carried out as a poststack application on 3D prestack migrated seismic data volumes. However, since its inception, interpreters have applied coherence to band-pass-filtered data, azimuthally limited stacks, and offset-limited stacks to enhance discontinuities seen at specific frequencies, azimuths, and offsets. The limitation of this approach is the multiplicity of coherence volumes. Of the various coherence algorithms that have evolved over the past 25 years, the energy ratio coherence computation stands apart from the others, being more sensitive to the seismic waveform changes rather than changes in their amplitude. The energy ratio algorithm is based on the crosscorrelation of five or more adjacent traces to form a symmetric covariance matrix that can then be decomposed into eigenvalues and eigenvectors. The first eigenvector represents a vertically variable, laterally consistent pattern that best represents the data in the analysis window. The first eigenvalue represents the energy of the data represented by this pattern. Coherence is then defined as the ratio of the energy represented by the first eigenvalue to the sum of the energy of the original data. An early generalization of this algorithm was to compute the sum of two covariance matrices, one from the original data and the other from the 90° phase rotated data, thereby eliminating artifacts about low-amplitude zero crossings. More recently, this concept has been further generalized by computing a sum of covariance matrices of traces represented by multiple spectral components, by their azimuthally limited stacks, and by their offset-limited stacks. These more recently developed algorithms capture many of the benefits of discontinuities seen at specific frequencies, azimuths, and offsets, but they present the interpreter with a single volume. We compare the results of multispectral, multiazimuth, and multioffset coherence volumes with the traditional coherence computation, and we find that these newer coherence computation procedures produce superior results.
Deep Learning for Natural Language Processing in Urology: State-of-the-Art Automated Extraction of Detailed Pathologic Prostate Cancer Data From Narratively Written Electronic Health Records
Authors: Leyh-Bannurah Sami-Ramzi , Tian Zhe , Karakiewicz Pierre I. , Wolffgang Ulrich , Sauter Guido , Fisch Margit , Pehrke Dirk , Huland Hartwig , Graefen Markus , Budäus Lars
Published: December 2018

Purpose

Entering all information from narrative documentation for clinical research into databases is time consuming, costly, and nearly impossible. Even high-volume databases do not cover all patient characteristics and drawn results may be limited. A new viable automated solution is machine learning based on deep neural networks applied to natural language processing (NLP), extracting detailed information from narratively written (eg, pathologic radical prostatectomy [RP]) electronic health records (EHRs).

Methods

Within an RP pathologic database, 3,679 RP EHRs were randomly split into 70% training and 30% test data sets. Training EHRs were automatically annotated, providing a semiautomatically annotated corpus of narratively written pathologic reports with initially context-free gold standard encodings. Primary and secondary Gleason pattern, corresponding percentages, tumor stage, nodal stage, total volume, tumor volume and diameter, and surgical margin were variables of interest. Second, state-of-the-art NLP techniques were used to train an industry-standard language model for pathologic EHRs by transfer learning. Finally, accuracy of the named entity extractors was compared with the gold standard encodings.

Results

Agreement rates (95% confidence interval) for primary and secondary Gleason patterns each were 91.3% (89.4 to 93.0), corresponding to the following: Gleason percentages, 70.5% (67.6 to 73.3) and 80.9% (78.4 to 83.3); tumor stage, 99.3% (98.6 to 99.7); nodal stage, 98.7% (97.8 to 99.3); total volume, 98.3% (97.3 to 99.0); tumor volume, 93.3% (91.6 to 94.8); maximum diameter, 96.3% (94.9 to 97.3); and surgical margin, 98.7% (97.8 to 99.3). Cumulative agreement was 91.3%.

Conclusion

Our proposed NLP pipeline offers new abilities for precise and efficient data management from narrative documentation for clinical research. The scalable approach potentially allows the NLP pipeline to be generalized to other genitourinary EHRs, tumor entities, and other medical disciplines.
Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma
Authors: Ennishi Daisuke , Jiang Aixiang , Boyle Merrill , Collinge Brett , Grande Bruno M. , Ben-Neriah Susana , Rushton Christopher , Tang Jeffrey , Thomas Nicole , Slack Graham W. , Farinha Pedro , Takata Katsuyoshi , Miyata-Takata Tomoko , Craig Jeffrey , Mottok Anja , Meissner Barbara , Saberi Saeed , Bashashati Ali , Villa Diego , Savage Kerry J. , Sehn Laurie H. , Kridel Robert , Mungall Andrew J. , Marra Marco A. , Shah Sohrab P. , Steidl Christian , Connors Joseph M. , Gascoyne Randy D. , Morin Ryan D. , Scott David W.
Published: December 2018

Purpose

High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2) and diffuse large B-cell lymphoma (DLBCL) morphology through examination of gene expression.

Patients and Methods

We analyzed RNA sequencing data from 157 de novo germinal center B-cell-like (GCB)-DLBCLs, including 25 with HGBL-DH/TH- BCL2, to define a gene expression signature that distinguishes HGBL-DH/TH- BCL2 from other GCB-DLBCLs. To assess the genetic, molecular, and phenotypic features associated with this signature, we analyzed targeted resequencing, whole-exome sequencing, RNA sequencing, and immunohistochemistry data.

Results

We developed a 104-gene double-hit signature (DHITsig) that assigned 27% of GCB-DLBCLs to the DHITsig-positive group, with only one half harboring MYC and BCL2 rearrangements (HGBL-DH/TH- BCL2). DHITsig-positive patients had inferior outcomes after rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy compared with DHITsig-negative patients (5-year time to progression rate, 57% and 81%, respectively; P < .001), irrespective of HGBL-DH/TH- BCL2 status. The prognostic value of DHITsig was confirmed in an independent validation cohort. DHITsig-positive tumors are biologically characterized by a putative non–light zone germinal center cell of origin and a distinct mutational landscape that comprises genes associated with chromatin modification. A new NanoString assay (DLBCL90) recapitulated the prognostic significance and RNA sequencing assignments. Validating the association with HGBL-DH/TH- BCL2, 11 of 25 DHITsig-positive–transformed follicular lymphomas were classified as HGBL-DH/TH- BCL2 compared with zero of 50 in the DHITsig-negative group. Furthermore, the DHITsig was shared with the majority of B-cell lymphomas with high-grade morphology tested.

Conclusion

We have defined a clinically and biologically distinct subgroup of tumors within GCB-DLBCL characterized by a gene expression signature of HGBL-DH/TH- BCL2. This knowledge has been translated into an assay applicable to routinely available biopsy samples, which enables exploration of its utility to guide patient management.
Patient Characteristics, Early Outcomes, and Implementation Lessons of Cervical Cancer Treatment Services in Rural Rwanda
Authors: Park Paul H. , Davey Sonya , Fehr Alexandra E. , Butonzi John , Shyirambere Cyprien , Hategekimana Vedaste , Bigirimana Jean Bosco , Borg Ryan , Uwizeye Regis , Tapela Neo , Shulman Lawrence N. , Randall Thomas , Mpanumusingo Egide , Mpunga Tharcisse
Published: December 2018

Purpose

Low- and middle-income countries account for 86% of all cervical cancer cases and 88% of cervical cancer mortality globally. Successful management of cervical cancer requires resources that are scarce in sub-Saharan Africa, especially in rural settings. Here, we describe the early clinical outcomes and implementation lessons learned from the Rwanda Ministry of Health’s first national cancer referral center, the Butaro Cancer Center of Excellence (BCCOE). We hypothesize that those patients presenting at earlier stage and receiving treatment will have higher rates of being alive.

Methods

The implementation of cervical cancer services included developing partnerships, clinical protocols, pathology services, and tools for monitoring and evaluation. We conducted a retrospective study of patients with cervical cancer who presented at BCCOE between July 1, 2012, and June 30, 2015. Data were collected from the electronic medical record system and by manually reviewing medical records. Descriptive, bivariable and multivariable statistical analyses were conducted to describe patient demographics, disease profiles, treatment, and clinical outcomes.

Results

In all, 373 patients met the study inclusion criteria. The median age was 53 years (interquartile rage, 45 to 60 years), and 98% were residents of Rwanda. Eighty-nine percent of patients had a documented disease stage: 3% were stage I, 48% were stage II, 29% were stage III, and 8% were stage IV at presentation. Fifty percent of patients were planned to be treated with a curative intent, and 54% were referred to chemoradiotherapy in Uganda. Forty percent of patients who received chemoradiotherapy were in remission. Overall, 25% were lost to follow-up.

Conclusion

BCCOE illustrates the feasibility and challenges of implementing effective cervical cancer treatment services in a rural setting in a low-income country.
Redes e emaranhados no mundo digital
Authors: Tonelli Maria José , Wilner Adriana
Published: December 2018

Tal como a energia nuclear, nosso mundo em redes traz muitos aspectos positivos e outros nem tanto. Se, de um lado, as redes podem permitir a circulação em tempo real de notícias; de outro, as mídias sociais têm sido questionadas quanto ao seu potencial destruidor da vida democrática, como destacou Carlos Eduardo Lins da Silva, em artigo para o jornal Valor Econômico.
Fake news no mundo corporativo
Authors: Blikstein Izidoro , Fernandes Manoel , Coutinho Marcelo
Published: December 2018

A criação de estruturas capazes de responder rapidamente à disseminação de notícias falsas sobre a empresa é o caminho mais eficiente para combater uma crise de comunicação na era digital.
Recent advances in understanding the physiology of hypoxic sensing by the carotid body
Authors: Prabhakar Nanduri R. , Peng Ying-Jie , Nanduri Jayasri
Published: December 2018

Hypoxia resulting from reduced oxygen (O2) levels in the arterial blood is sensed by the carotid body (CB) and triggers reflex stimulation of breathing and blood pressure to maintain homeostasis. Studies in the past five years provided novel insights into the roles of heme oxygenase-2 (HO-2), a carbon monoxide (CO)-producing enzyme, and NADH dehydrogenase Fe-S protein 2, a subunit of the mitochondrial complex I, in hypoxic sensing by the CB. HO-2 is expressed in type I cells, the primary O2-sensing cells of the CB, and binds to O2 with low affinity. O2-dependent CO production from HO-2 mediates hypoxic response of the CB by regulating H2S generation. Mice lacking NDUFS2 show that complex I-generated reactive oxygen species acting on K+ channels confer type I cell response to hypoxia. Whether these signaling pathways operate synergistically or independently remains to be studied.
Empresarização da saúde pública: o caso da EBSERH
Authors: Borges Janiele Cristine Peres , Barcelos Márcio , Rodrigues Marcio Silva
Published: December 2018

Tomando como objeto empírico a constituição e implementação da Empresa Brasileira de Serviços Hospitalares (EBSERH), o objetivo deste texto é analisar como a ideia de empresarização, isto é, como a generalização da forma empresa se expressa nesse processo. Para tanto, realizou-se uma análise documental, tendo como corpus de análise um conjunto de documentos oficiais que estruturaram o processo de constituição e implementação da EBSERH. Dentre os principais achados ressalta-se o papel dos órgãos de controle e fiscalização, especialmente o TCU, que após a identificação de problemas na gestão dos hospitais universitários federais, passou a preconizar soluções empresarias. Dentro desse modelo, termos como “metas”, “indicadores”, “responsabilidade por resultados”, “parâmetros de produtividade”, “benchmarking” surgem como balizadores para o que seria concebido como “boas práticas” que deveriam ser inseridas na gestão pública.
The development of the school and pedagogics in RUSSIA after the october revolution of 1917
Authors: Рабаданова Разият , Rabadanova Raziyat , Степанова Ирина , Stepanova Irina
Published: December 2018

The history of the Russian school and pedagogy of the Soviet period turned out to be extremely dramatic and contradictory. The movement of education along the ascending line, the increment of pedagogical knowledge took place in social conditions that impede free ideological controversy, in an atmosphere of repression, dictatorship and censorship of official authorities, and reduced contact with world pedagogical science and educational practice. The article deals with the problem of building a modern system of education quality management is inextricably linked with the change of the existing content of education and educational technologies.
Metro Uses a Simulation-Optimization Approach to Improve Fare-Collection Shift Scheduling
Authors: Miranda Jaime , Rey Pablo A. , Sauré Antoine , Weber Richard
Published: December 2018

The authors describe a simulation-optimization method for determining shift schedules for fare collectors in a subway network. They use an integer programming model to generate shift schedules and a discrete-event simulation model to evaluate the corresponding service levels (i.e., average number of users waiting in line over time).
Our 2018 Referee of the Year
Authors: Leslie Stephen
Published: December 2018

The British Journal of Cardiac Nursing 2018 Referee of the Year is Stephen Leslie Consultant Cardiologist, NHS Highlands; and Honorary Professor, University of the Highlands and Islands
Clarifying the management of new-onset atrial fibrillation
Authors: Sampson Michael
Published: December 2018

In last month's issue, we published a clinical protocol for atrial fibrillation in acute settings by Munawar and Millward. Here, Michael Sampson presents a response to the article and aims to add context and clarity to some potentially misleading statements made in the original protocol
The role of ACE inhibitors in cardiovascular disease
Authors: O'Donovan Kate
Published: December 2018

Cardiovascular disease is the leading cause of death in the UK, with heart failure and ischaemic heart disease the commonest forms of the condition. The renin–angiotensin–aldosterone system is recognised as having an integral pathophysiological role by increasing afterload, promoting sodium and water retention and contributing to ventricular remodelling. Evidence from randomised controlled trials has demonstrated that angiotensin-converting enzyme (ACE) inhibitors reduce mortality, slow disease progression and reduce left ventricular workload. This is achieved by inhibiting the conversion of angiotensin I to angiotensin II. Preload and afterload are reduced, which preserves left ventricular function. Common adverse effects include cough, hypotension, hyperkalaemia and a decline in renal function. The nurses' role in caring for patients receiving ACE inhibitor therapy includes clinical assessment, monitoring and detecting adverse effects as well as patient education.
Seeking an order to withdraw treatment from the Court of Protection
Authors: Griffith Richard
Published: December 2018

The Court of Protection is the specialist court that makes decisions in relation to people who lack decision-making capacity. In this article, Richard Griffith considers the powers of the Court of Protection and discusses when it might be necessary for a district nurse to seek an order from the court in relation to the care or treatment of a patient.
Wound Exudate
Authors: Bradley Peter
Published: December 2018

Tina Chambers, Independent Tissue Viability Consultant
Matematik Öğretmen Adaylarının Geometrik Cisimler Konusuna Yönelik Tutumları ve Geometriye Yönelik Öz-Yeterlikleri
Authors: ÇAĞIRGAN Dilek , Yavuz Güneş , DERİNGÖL Yasemin
Published: December 2018

Geometri, gerek matematik
öğretiminde, gerekse günlük yaşamda önemli bir yer teşkil etmektedir. Ancak,
geometri dersi öğrenciler tarafından zor olarak nitelendirilmektedir. Bir diğer
taraftan da geometrik cisimler ve geometrik şekiller arasındaki farklılıklar
kavram olarak karıştırılmaktadır. Bu karmaşıklığı gidermede ve temel bilgiyi
vermede, öğretmenlere büyük görev düşmektedir. Bu bağlamda; bu araştırma,
matematik öğretmen adaylarının geometrik cisimler konusuna yönelik tutumları ve
geometriye yönelik öz-yeterliklerinin incelenmesi amacıyla yapılmıştır. Araştırma,
2016-2017 bahar yarıyılında İstanbul ilindeki bir üniversitenin İlköğretim Matematik
Öğretmenliği programında öğretmen adaylarıyla gerçekleştirilmiştir. Araştırma
verileri, “Geometri Öz-yeterlik Ölçeği” ve “Geometrik Cisimler Konusuna Yönelik Tutum Ölçeği” ile
toplanmıştır. Tarama modeli ile yürütülen bu araştırma verileri SPSS 16 ile
analiz edilmiştir. Verilerin çözümlenmesinde Mann-Whitney U Testi, Kruskal
Wallis Testi ve Spearman Sıra Korelasyon Katsayısı Tekniği istatistiksel
yöntemleri kullanılmıştır. Matematik
öğretmen adaylarının geometrik cisimler konusuna yönelik tutumlarının ve
geometri öz-yeterliklerinin yüksek olduğu; cinsiyete göre farklılaşmadığı,
geometri öğretmeyi seven öğretmen adayları lehine tutumların ve
öz-yeterliklerin yüksek olduğu sonucuna ulaşılmıştır.
A Scientometric Profile of Sant Gadge Baba Amravati University, Amravati During 1996-2017
Authors: Bapte Vishal Dattatray , Gedam Jyoti
Published: December 2018

The study presents the scientometric profile of Sant Gadge Baba Amravati University (SGBAU), Amravati during 1996-2017. The required research output for the study has been pulled out from SCOPUS database on the basis of affiliation based search. The complete research output is 1130 with 11.67% average citations per paper. The highest H-index (17) was found in the year 2013. 20.08% documents were produced though international collaboration. SGBAU, Amravati has the largest collaboration with Brazil (69) and United States (21). Authorship pattern predicts collaborative trend. Research papers produced with three authors have got the maximum (4444) citations. Journals (839) and Conference papers (174) are the most popular source type preferred by the faculty of SGBAU for research expression. Mahendra Rai (209), S. K. Omnwar (143) and Anand S. Aswar (94) are the most prolific authors. It is noteworthy that Alka P. Yadav has got 3073 citations for her 17 papers. Most of the articles are published in the domain of Physics and Astronomy (356). With regard to institutional collaboration, the faculty members of the SGBAU have confined themselves to the Maharashtra state most of the time. Data visualization is carried out using VOSviewer

 
Los visitantes en los museos de arte argentinos: consideraciones a partir de los estudios de visitantes/públicos
Authors: Panozzo Zenere Gabriela
Published: December 2018

El modelo museístico contemporáneo establece una lógica de disciplinamiento vinculado a múltiples ofertas de experiencias, de entretenimiento, de consumo y de diálogo. En este esquema, los gustos, los intereses y las necesidades de los visitantes se vuelven fundamentales para que el museo se reconfigure ante los desafíos del sistema capitalista.La discusión del presente texto, abordará las contrariedades que presentan los museos de arte argentinos al generar instancias de indagación sobre sus públicos. Para ello, el trabajo procura desentrañar el nuevo vínculo que se establece con los visitantes desde un contexto determinado y una tipología específica, lo que ayuda a comprender la dinámica que adquieren estos establecimientos en la contemporaneidad.En líneas generales, se apela a un cruce de contenidos sustentados en los enfoques teóricos críticos aplicados a la museología y los estudios de visitantes y, en lo específico, se aportan datos analíticos sobre la utilización los estudios de visitantes en los museos de arte argentinos. Además, se recurre al estudio de casos múltiples al describir algunos estudios que permiten reconocer instancias de diálogo en la dinámica museal.
“10 Minutos” Performance Digital. Una hibridación cuerpoimagen-sonido
Authors: Ariza Daniel , Guzmán Adriana , Murcia Alejandra , Martínez Fabián
Published: December 2018

La obra 10 Minutos, performance digital, plantea, a través de cuatro acciones performáticas en entornos digitales, la tensión cuerpo / máquina presente en vivencias y memorias de pacientes y su devenir en una Unidad de Cuidado Intensivo (UCI). La propuesta busca introducir al espectador en esta tensión generada en el entorno de la UCI, a través del performance, la imagen, textos e hipertextos, el sonido, el movimiento, la danza, el olor, la instalación; trascendiendo la experiencia del visitante para que pueda ser afectado por el dolor, el sufrimiento, el anhelo, la impotencia, el delirio, la inminencia de la muerte. El presente artículo busca dar cuenta del proceso de configuración poética y artística de la obra, para lo cual hace un recorrido por las diferentes escenas de la misma.
REHABILITASI DALAM UPAYA DERADIKALISASI NARAPIDANA TERORISME
Authors: Mareta Josefhin
Published: December 2018

Penggunaan kekerasan dalam menangani terorisme tidak benar-benar berhasil menyelesaikan permasalahan terorisme hingga ke akarnya sehingga diperlukan upaya mengubah pemikiran radikal para pelaku dengan melakukan deradikalisasi. Deradikalisasi narapidana terorisme memiliki berbagai hambatan diantaranya narapidana yang tidak kooperatif dan kurangnya sarana pendukung. Parameter keberhasilan deradikalisasi diperlukan dalam rangka memperkuat dan mengevaluasi hasil rehabilitasi narapidana terorisme sehingga penelitian ini penting untuk dilakukan. Penelitian ini menggunakan metode penelitian kualitatif dengan mengumpulkan data primer dan data sekunder. Hasil penelitian menggambarkan terorisme sebagai permasalahan individual yang membutuhkan pembinaan khusus sesuai prinsip individual pembinaan, dan tahapan dalam pelaksanaan rehabilitasi narapidana terorisme sehingga dalam pelaksanaan rehabilitasi yang efektif diperlukan partisipasi narapidana dan fasilitator, ketersediaan prosedur dan modul pembinaan, serta evaluasi keberhasilan rehabilitasi narapidana terorisme.
Sex steroid hormone stability in serum tubes with and without separator gels
Authors: Hepburn Sophie , Wright Michael J.P. , Boyder Conchita , Sahertian Renee C. , Lu Ben , Zhang Rui , White Chris P. , Horvath Andrea R.
Published: December 2018

Background:

A pilot study showing a decrease in androstenedione concentration in serum collected into gel-containing serum tubes (STs) triggered an investigation of the effect of serum collection tube on steroid hormone stability.

Methods:

In the main study, two tube types were examined: BD Vacutainer®SST™IIAdvanceand BD Vacutainer®Serum Tube. Forty-seven serum samples from apparently healthy volunteers were collected and analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for testosterone, androstenedione, 17-hydroxyprogesterone (17-OHP) (n=20); and oestradiol (n=27). Primary specimens were centrifuged once, maintained at room temperature and extracted within 2 h for day zero (d0) results. To assess stability following refrigeration (2–8 °C), aliquots were taken from the primary tube on day one (d1) and day five (d5) and analysed immediately. Differences in measurand concentration between tubes at d0 and following storage (d1 and d5) were evaluated for statistical significance.

Results:

There was a progressive and statistically significant decrease in androstenedione concentration from d0 to d5 (p<0.001) in the SST™II tubes. In addition, there was a statistically significant reduction in testosterone, 17-OHP and oestradiol concentrations at d5 (p<0.01). Interestingly, oestradiol and testosterone concentrations increased with time in plain STs (p<0.01). The only change likely to have a clinical impact was that of androstenedione in serum gel tubes.

Conclusions:

To optimise conditions and to reduce pre-analytical error we recommend the use of plain serum collection tubes for androstenedione and rapid separation of serum from cells when oestradiol and testosterone are requested.