Image processing and analysis methods for the Adolescent Brain Cognitive Development Study
Authors: Hagler Donald J , Hatton Sean N , Makowski Carolina , Cornejo M Daniela , Fair Damien A , Dick Anthony Steven , Sutherland Matthew T , Casey BJ , Barch Deanna M , Harms Michael P , Watts Richard , Bjork James M , Garavan Hugh P , Hilmer Laura , Pung Christopher J , Sicat Chelsea S , Kuperman Joshua , Bartsch Hauke , Xue Feng , Heitzeg Mary M , Laird Angela R , Trinh Thanh T , Gonzalez Raul , Tapert Susan F , Riedel Michael C , Squeglia Lindsay M , Hyde Luke W , Rosenberg Monica D , Earl Eric A , Howlett Katia D , Baker Fiona C , Soules Mary , Diaz Jazmin , Leon Octavio Ruiz de , Thompson Wesley K , Neale Michael C , Herting Megan , Sowell Elizabeth R , Alvarez Ruben P , Hawes Samuel W , Sanchez Mariana , Bodurka Jerzy , Breslin Florence J , Morris Amanda Sheffield , Paulus Martin P , Simmons W Kyle , Polimeni Jonathan R , Kouwe Andre van der , Nencka Andrew S , Gray Kevin M , Pierpaoli Carlo , Matochik John A , Noronha Antonio , Aklin Will M , Conway Kevin , Glantz Meyer , Hoffman Elizabeth , Little Roger , Lopez Marsha , Pariyadath Vani , Weiss Susan RB , Wolff-Hughes Dana L , DelCarmen-Wiggins Rebecca , Ewing Sarah W Feldstein , Miranda-Dominguez Oscar , Nagel Bonnie J , Perrone Anders J , Sturgeon Darrick T , Goldstone Aimee , Pfefferbaum Adolf , Pohl Kilian M , Prouty Devin , Uban Kristina , Bookheimer Susan Y , Dapretto Mirella , Galvan Adriana , Bagot Kara , Giedd Jay , Infante M Alejandra , Jacobus Joanna , Patrick Kevin , Shilling Paul D , Desikan Rahul , Li Yi , Sugrue Leo , Banich Marie T , Friedman Naomi , Hewitt John K , Hopfer Christian , Sakai Joseph , Tanabe Jody , Cottler Linda B , Nixon Sara Jo , Chang Linda , Cloak Christine , Ernst Thomas , Reeves Gloria , Kennedy David N , Heeringa Steve , Peltier Scott , Schulenberg John , Sripada Chandra , Zucker Robert A , Iacono William G , Luciana Monica , Calabro Finnegan J , Clark Duncan B , Lewis David A , Luna Beatriz , Schirda Claudiu , Brima Tufikameni , Foxe John J , Freedman Edward G , Mruzek Daniel W , Mason Michael J , Huber Rebekah , McGlade Erin , Prescot Andrew , Renshaw Perry F , Yurgelun-Todd Deborah A , Allgaier Nicholas A , Dumas Julie A , Ivanova Masha , Potter Alexandra , Florsheim Paul , Larson Christine , Lisdahl Krista , Charness Michael E , Fuemmeler Bernard , Hettema John M , Steinberg Joel , Anokhin Andrey P , Glaser Paul , Heath Andrew C , Madden Pamela A , Baskin-Sommers Arielle , Constable R Todd , Grant Steven J , Dowling Gayathri J , Brown Sandra A , Jernigan Terry L , Dale Anders M 
Published: November 2018

The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The ABCD Study is a collaborative effort, including a Coordinating Center, 21 data acquisition sites across the United States, and a Data Analysis and Informatics Center (DAIC). The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other outcomes. The study employs state-of-the-art multimodal brain imaging, cognitive and clinical assessments, bioassays, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning. The data will provide a resource of unprecedented scale and depth for studying typical and atypical development. Here, we describe the baseline neuroimaging processing and subject-level analysis methods used by the ABCD DAIC in the centralized processing and extraction of neuroanatomical and functional imaging phenotypes. Neuroimaging processing and analyses include modality-specific corrections for distortions and motion, brain segmentation and cortical surface reconstruction derived from structural magnetic resonance imaging (sMRI), analysis of brain microstructure using diffusion MRI (dMRI), task-related analysis of functional MRI (fMRI), and functional connectivity analysis of resting-state fMRI.

Highlights

An overview of the MRI processing pipeline for the ABCD Study

A discussion on the challenges of large, multisite population studies

A methodological reference for users of publicly shared data from the ABCD Study