bluuebunny/crossref_metadata_2025 huggingface dataset:
Apalutamide for metastatic castration-sensitive prostate cancer: final analysis of the Asian subpopulation in the TITAN trial
Authors: Chung Byung Ha , Huang Jian , Uemura Hiroji , Choi Young Deuk , Ye Zhang-Qun , Suzuki Hiroyoshi , Kang Taek Won , He Da-Lin , Joung Jae Young , Brookman-May Sabine D , McCarthy Sharon , Bhaumik Amitabha , Singh Anildeep , Mundle Suneel , Chowdhury Simon , Agarwal Neeraj , Ye Ding-Wei , Chi Kim N , Uemura Hirotsugu
Published: June 2023

The final analysis of the phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen (TITAN) trial showed improvement in overall survival (OS) and other efficacy endpoints with apalutamide plus androgen deprivation therapy (ADT) versus ADT alone in patients with metastatic castration-sensitive prostate cancer (mCSPC). As ethnicity and regional differences may affect treatment outcomes in advanced prostate cancer, a post hoc final analysis was conducted to assess the efficacy and safety of apalutamide in the Asian subpopulation. Event-driven endpoints were OS, and time from randomization to initiation of castration resistance, prostate-specific antigen (PSA) progression, and second progression-free survival (PFS2) on first subsequent therapy or death. Efficacy endpoints were assessed using the Kaplan–Meier method and Cox proportional-hazards models without formal statistical testing and adjustment for multiplicity. Participating Asian patients received once-daily apalutamide 240 mg (n = 111) or placebo (n = 110) plus ADT. After a median follow-up of 42.5 months and despite crossover of 47 placebo recipients to open-label apalutamide, apalutamide reduced the risk of death by 32% (hazard ratio [HR]: 0.68; 95% confidence interval [CI]: 0.42–1.13), risk of castration resistance by 69% (HR: 0.31; 95% CI: 0.21–0.46), PSA progression by 79% (HR: 0.21; 95% CI: 0.13–0.35) and PFS2 by 24% (HR: 0.76; 95% CI: 0.44–1.29) relative to placebo. The outcomes were comparable between subgroups with low- and high-volume disease at baseline. No new safety issues were identified. Apalutamide provides valuable clinical benefits to Asian patients with mCSPC, with an efficacy and safety profile consistent with that in the overall patient population.
Perception of Gender Bias in Otolaryngology and Head & Neck Surgery - A Comparative Study
Authors: Lucidi Daniela , Reale Marella , Trecca Eleonora Maria Consiglia , Parini Sara , Verdi Daunia , Spolverato Gaya , Molinari Giulia
Published: June 2023

Introduction:

To investigate the differences in the professional and personal life and the perception of gender-bias, among Italian female surgeons working in Otolaryngology–Head and Neck Surgery (OHNS), as compared to those involved in other surgical fields (overall group [OG]).

Materials and Methods:

An online survey was administered to female medical doctors working in all surgical fields in Italian hospitals.

Results:

Of the 1963 responders included, 153 (7.8%) were part of the ONHS group and 1810 (92.3%) of the OG. In both cohorts, female represented approximately one-third of the surgical staff. At least one female in the staff did not regularly attend the operating room (OR), especially in the OHNSG group. OHNS responders had to abandon the surgical activities in favour of outpatient services more than OG. A higher proportion of OHNS surgeons encountered gender-related difficulties in the OR.

Discussion:

Several gender-related issues emerged among OHNS responders, the most relevant being involvement in surgical activities and number/complexity of surgical cases.
Soft-Tissue Augmentation in Periodontally Compromised Patients during Immediate Placement and Immediate Loading Dental Implant Surgery - A Retrospective Study
Authors: Lazarov Aleksandar
Published: June 2023

Introduction:

The purpose of this article is to describe a soft-tissue augmentation procedure for multiple tooth extraction sites during immediate placement and immediate loading (IPIL) dental implant surgery in periodontally compromised patients and to present follow-up results of its effectiveness.

Methods:

A retrospective study was conducted on data from patients who underwent IPIL dental implant surgery between 2018 and 2021 at an oral implant centre in Bulgaria. Based on inclusion and exclusion criteria, 103 patients were included, 53 of whom had pre-operative indications for connective tissue grafts (CTGs) and 50 of whom did not. The post-operative incidence of gum recession was evaluated in the two patient groups.

Results:

The majority of the 53 patients (56.60%) had six, seven or eight tooth sites grafted. A significant proportion (87%) needed CTGs at the canine teeth (13 and 23), P < 0.001. The post-operative data showed a low incidence of gum recessions in both the patient groups, with a lower rate in the CTG group at tooth no: 13 (2.20% vs. 18%, P = 0.016) and in the total sum of 10 tooth sites with CTGs (P = 0.001). A reduction in gum problems and increased satisfaction with gum health and aesthetics were reported by 100% of the CTG patients.

Discussion:

Soft-tissue augmentation at multiple tooth extraction sites during IPIL dental implant treatment may benefit periodontally compromised patients through an improved prosthesis–tissue interface in the aesthetic area and a reduction in gum infections, swelling, bleeding and pain.
Current Occupational Therapy and Physiotherapy Services for Children with Cerebral Palsy in India
Authors: Missal Sujata , Bidhya K. M.
Published: June 2023

Background:

Cerebral palsy (CP) is a common cause of chronic childhood disability and constitutes a substantial portion of paediatric occupational therapy (OT) and physical therapy (PT) practices. An analysis of current rehabilitation practices is necessary to use more recent, evidence-based, and effective treatment modalities. This study intends to explore the current rehabilitation trends in assessing and planning interventions for children with CP in India and finding the focus and gaps in treatment.

Objectives:

To describe the focus of therapy practices in OT and PT for children with CP and better understand whether it is congruent with recommended practices.

Study Design:

A cross-sectional survey.

Methods:

An India-wide web-based survey on “Rehabilitation services for children with CP: A survey of what we do and how we individualize treatment for different children” (self-designed questionnaire) was completed by 50 occupational and 12 physical therapists to identify assessments and treatment interventions based on their clinical practice. Data were coded using the International Classification of Functioning, Disability, and Health (ICF) definitions for “body functions and structure,” “activity and participation,” and “environment.” Descriptive and quantitative statistics were used to identify the focus and gaps.

Results:

Both professions focused primarily on body structure and function assessment (OT: 28 [56%] and PT: 8 [66.7%]) when assessing and intervening. “Activity and participation” related assessment was focussed more by physiotherapists 4 (33.3%) than occupational therapists 15 (30%). Majority 44 (71.09%) of the therapists chose interventions that came under the ICF category: Activity and participation. While the percentage of therapists focussing on body structure and function and contextual factors interventions were 28 (45.02%) and 32 (52.27%), respectively. Attention, however, was mainly directed toward task-oriented activities such as activities of daily living and mobility 49 (79%). Participation in leisure or community-based activities received comparatively least attention 35 (56.5%). The environment received limited attention for assessments, although it was an important focus of intervention (environment modifications: 47 [75.8%]).OTs focused more on sensory components (U = 173.000, P = 0.019, 95% confidence interval [CI]: 0.017 to 0.022, mdn = 1.00) and, PTs focused more on gait (U = 192.000, P = 0.046, 95% CI: 0.0.039 to 0.047, mdn = 2.00) and trunk impairment (U = 129.000, P = 0.001, 95% CI: 0.0.000 to 0.001, mdn = 1.00).

Conclusion:

While body functions and structure are well-addressed, other ICF elements, specifically participation, are poorly integrated into practice. The emerging focus on the environment in therapy intervention, by modifying the context rather than changing aspects of the child, is consistent with current approaches and evidence. Knowledge translation implementation initiatives are recommended to bridge identified gaps.
Nicotine Free Herbal Composition for Smoking De-Addiction - A Placebo Controlled, Double Blind, Randomized, Multicentric Clinical Study
Authors: Tamoli Sanjay Motilal , Harit Mahesh Kumar , Mundhe Narendra , Pande Shishir Purushottam , Damle Neena , Chavan Sheetal , Kamde Rahul , Pawar Vinay Ankush , Mahadik Swapnali
Published: June 2023

ABSTRACT

Background:

Smoking is a major predisposing factor for many health problems including cancers, vascular disorders, etc., To quit smoking is the only solution to prevent them. Various medicinal and non-medicinal methods are used worldwide for the same. The present study evaluates the effect of a nicotine free herbal formulation containing ingredients like Mucuna pruriens, Withania somnifera, Bacopa monnieri, etc., for cessation of smoking and its effects on other health parameters related to smoking.

Materials and Methods:

The present study was a placebo controlled, double blind, randomized, and multi-centric clinical study conducted at three clinical sites in India. After ethical approval and informed consent, all participants were given Smotect Tablets or Placebo tablets in a dose of 2 tablets twice daily for 90 days. A total of 103 participants (52 in trial group and 51 in placebo group) completed the study. Evaluation of cessation of smoking was done along with other parameters like measurement of lung capacity, clinical assessment, and laboratory investigations before and after the study.

Results:

A significant reduction in smoking as well as in the alveolar Carbon monoxide (p < 0.05) and Carboxyhemoglobin levels (p < 0.05) were observed with the use of Smotect tablets as compared to placebo over a period of 90 days. Significant improvement was also observed in quality of life, energy and stamina levels, and reduction of stress level. Smotect tablets were found to be safe without causing any adverse effects.

Conclusion:

Smotect Tablets is an effective and safe remedy for cessation of smoking and reducing other effects related to smoking.
Antidiabetic Activity of Combination of Binahong (Anredera cordifolia Ten. Steenis), Cherry (Muntingia calabura L.) and Brotowali (Tinospora crispa L.) Extracts
Authors: Kusriani Herni , Susilawati Elis , Nurafipah Lytia , Nurkholifah
Published: June 2023

ABSTRACT

Background:

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. Diabetes mellitus is a silent killer because sufferers are often not aware of it when it is realized, complications have occurred. Treatment for this disease must be done for life to control blood sugar in the body; however, oral antidiabetic drugs often produce unwanted side effects such as bloating, diarrhea, and stomach cramps. One of the treatments for diabetes is to find sources of treatment using natural ingredients that are relatively safe, including using plants as medicines. Based on several studies, Binahong leaves (Anredera cordifolia Ten. Steenis), brotowali (Tinospora crispa L.), and cherry (Muntingia calabura L.) are medicinal plants that can be used to reduce blood sugar levels. This study aims to test the antidiabetic activity using in vivo and in vitro testing methods of extracts of binahong leaves, cherry leaves, brotowali stems and their combinations.

Methods:

In vivo method uses animal modeling of insulin deficiency, whereas in vitro method with alpha glycosidase inhibition activity assay. The administration of extracts was repeated every day for 14 days and blood glucose levels were measured on the 0, 7th, and 14th days. Then surgery was performed on the pancreas and calculated the area of the islets of Langerhans, and the number of alpha and beta cells in the pancreas. The inhibitory activity of the alpha-glucosidase enzyme with the IC50 value of each extract and its combination was determined, with acarbose used as a standard.

Result:

The combination of binahong leaves (Anredera cordifolia Ten.Steenis) and cherry leaves (Muntingia calabura L.) and the combination of brotowali stems (Tinospora crispa (L.) and binahong leaves showed in vivo antidiabetic activity with insulin deficiency method. The combination of these extracts was able to reduce blood sugar levels until the observation on day 14. In in vitro testing by inhibiting alpha-glucosidase enzymes, binahong leaves extract, brotowali stems, and cherry leaves were able to inhibit alpha-glucosidase enzymes at IC50 of 35.07 ± 2.35; 29.42 ± 1.40; and 26.63 ± 1.15, respectively.

Conclusion:

The best combination of extracts by in vitro and in vivo methods was shown in the combination of binahong leaf and brotowal stem extract binahong leaves, brotowali stems (2:1).
Past, Present, and Likely Future of Nutraceuticals in India: Evolving Role of Pharmaceutical Physicians
Authors: Malve Harshad , Bhalerao Pramod
Published: June 2023

ABSTRACT

Nutraceuticals are gaining importance owing to the current pandemic situation and increasing focus on overall health. Nutraceuticals include products, which help in maintaining immunity and prevent diseases. It also includes products that support the optimal functioning of the human body. Poor nutrition plays an important role in lifestyle-related disorders as well. Various nutraceuticals have exhibited therapeutic potential, hence gaining popularity. Nutraceuticals are mainly categorized into dietary supplements and functional foods. With multiple factors contributing to the growth of nutraceutical industry in India, we are marching toward global leadership in nutraceuticals. Food Safety and Standards Authority of India (FSSAI) is solely responsible for regulating the approvals, promotions, and labeling standards for health supplements and nutraceuticals. As the understanding of these nutraceuticals is improving, the regulations are becoming stricter and there is a pressing need to monitor the usage of such products regularly and stringently. Nutrivigilance and phytovigilance are relatively new concepts in our country; however, regulatory authorities need to proactively observe the adverse effects and issues related to substandard and counterfeit nutraceutical products. Healthcare professionals including pharmaceutical physicians can play an important role in safeguarding the population by advocating the rational use of nutraceuticals, food supplements, and consumer health products.
Experimental and Analytical Evaluation of an Acceleration-Based
Semiactive Control Strategy for Automotive Suspension Systems with
Magneto-Rheological Damper
Authors: Jamadar Mohibb e Hussain , Devikiran Pinjala , Kumar Hemantha , Joladarshi Sharnappa
Published: June 2023

Most of the control strategies presented to date are based on either the
velocities or displacement of the vehicle body and the wheel which are derived
by filtering and converting the data from the accelerometer. This increases the
computational load and therefore directly affects the performance of the
semiactive suspension system. This study presents a control strategy purely
based on the acceleration for semiactive control of vehicle suspension with a
magneto-rheological MR damper. The effectiveness of the acceleration-based
skyhook (ASH) control strategy is compared with the existing velocity-based
skyhook (VSH) control strategy based on the vibration response of a
single-degree-of-freedom (SDOF) system. The effectiveness of ASH is evaluated
experimentally, and the reaction time is evaluated analytically. The
experimental results revealed that the ASH reduces the peak displacement and
peak acceleration of the mass under the free vibration test and also improves
the settling time as compared to VSH. The amplitude of the displacement and
acceleration was also found to be reduced under the forced vibration test with
maximum improvement observed during high-frequency excitation. The reaction time
of ASH was also found to be considerably lower than VSH. Therefore, it was
learned that the proposed ASH performed better under high-frequency excitation
than under lower-frequency excitation. Moreover, the lower reaction time of the
ASH could improve the overall performance of the semiactive suspension
system.
Lacon-, Shrub- and Parity-Decompositions: Characterizing Transductions of Bounded Expansion Classes
Authors: Dreier Jan
Published: June 2023

The concept of bounded expansion provides a robust way to capture sparse
graph classes with interesting algorithmic properties. Most notably, every
problem definable in first-order logic can be solved in linear time on bounded
expansion graph classes. First-order interpretations and transductions of
sparse graph classes lead to more general, dense graph classes that seem to
inherit many of the nice algorithmic properties of their sparse counterparts.
In this paper, we show that one can encode graphs from a class with
structurally bounded expansion via lacon-, shrub- and parity-decompositions
from a class with bounded expansion. These decompositions are useful for
lifting properties from sparse to structurally sparse graph classes.
Gabor frames from contact geometry in models of the primary visual cortex
Authors: Liontou Vasiliki , Marcolli Matilde
Published: June 2023

We analyze the interplay between contact geometry and Gabor filters signal
analysis in geometric models of the primary visual cortex. We show in
particular that a specific framed lattice and an associated Gabor system is
determined by the Legendrian circle bundle structure of the $3$-manifold of
contact elements on a surface (which models the V1-cortex), together with the
presence of an almost-complex structure on the tangent bundle of the surface
(which models the retinal surface). We identify a scaling of the lattice, also
dictated by the manifold geometry, that ensures the frame condition is
satisfied. We then consider a $5$-dimensional model where receptor profiles
also involve a dependence on frequency and scale variables, in addition to the
dependence on position and orientation. In this case we show that a proposed
profile window function does not give rise to frames (even in a distributional
sense), while a natural modification of the same generates Gabor frames with
respect to the appropriate lattice determined by the contact geometry.
Güneş Bacasında Verim Arttırılmasının Deneysel Olarak İncelenmesi
Authors: KARAKAYA Hakan , AVCI Ali Serkan , ÇETİNBAŞ Aytaç , DURMUŞ Aydın
Published: June 2023

Bu çalışma, güneş bacasının etkinliğinin arttırılması için iyileştirici düzenlemeler yapılarak deneysel olarak incelenmiştir. Deneysel çalışmada kullanılan güneş bacası daha önce Batman ilinde kurulan 12 m baca uzunluğuna ve 128 m2 kolektör alanına sahip bir prototiptir. Ölçümler için dört farklı coğrafi yönde eş zamanlı sıcaklık, hız ve radyasyon verileri alınarak sistemin ilk hali ile karşılaştırılmıştır. Öncelikle kolektör güneş ışınımı absorbe etmesi için zemini siyah renge boyanmıştır. Daha sonra sistemin gece saatlerinde çalışabilmesi için zemine sıcak su boruları eklenmiş ve türbin giriş hava hızının arttırılması için çelik plakalar ile 4 bölgeye ayrılmıştır. Elde edilen verileri göre kolektör cam yüzeyi altında ortalama sıcaklık artışının 17.4 %, türbin giriş sıcaklığının % 11.2 türbün giriş hızının % 9.94 ve sistem güç çıkışını % 9.4 oranında arttığı gözlemlenmiştir.
INFORMATION CHAOS ON THE INTERNET – PERCEPTION IN RELATION TO THE AGE OF USERS
Authors: Milosavljević Ilija , Trajković Jovana , Necić Neda
Published: June 2023

The rapid development of the Internet as a dominant medium in the field of information brought with it several novelties, caused by the nature of digital networked media. First and foremost is the hyperproduction of information as a result of each user’s free creation of content, but also the major problem of orientation in a narratively disconnected hyperspace and the proliferation of a large number of fake news. All of these changes resulted in the phenomenon of information chaos, or users’ disorientation in the Internet environment. In order to adapt to the new environment, users must learn a variety of new skills, which is much easier for younger generations than for older generations. The aim of the study is to determine to what extent users use the Internet for the purpose of information and in which ways they perceive information chaos. The goal is also to determine if there are any differences in the subjective feeling of disorientation on the Internet between younger and older users. The basic working hypothesis is that Internet users use the Internet as their primary source of information every day and are aware of information chaos on this medium, and that older users experience information chaos to a greater extent than younger users. The sample consists of 120 people divided into two groups: those aged 15 to 35 and those aged 45 and up. The data was collected using a specially designed questionnaire distributed via the Google Forms application, and the results were analyzed using descriptive and comparative statistics in the SPSS 24.0 program. The findings show that the respondents use the Internet for information on a daily basis, but certain differences in perception of the Internet chaos were noticed between age groups. Besides, younger respondents use the Internet as primary source of information, whereas older respondents use the Internet as a secondary source of information, that is as a supplement to other media.
Use of Augmented Reality in Illustrated Children's Books and an Application Example
Authors: KARAATA Ezgi , YILMAZ Necdet
Published: June 2023

This study aims to examine the relationship between augmented reality technology and illustrated children's books and convey the importance of children's literature by being supported with an application example. With the developments in digital technology deeply transforming visual media and the internet becoming an indispensable part of our lives, along with the widespread use of portable devices such as smartphones and tablets, it has also had an impact on traditional children's books. The opening of impressive visual worlds for children through augmented reality applications also reflects all of these. The study collected and presented data related to the history of augmented reality technology and the historical process of pop-up books, considered the predecessor of books designed with augmented reality. A literature review was conducted in chronological order to present the development of illustrated children's books produced with augmented reality technology. As part of the study, an augmented reality application was developed for a children's book project inspired by Hezârfen Ahmet Çelebi's flight from the Galata Tower, featuring traces of miniature art. The creation process and technical infrastructure of this application were also provided. Based on the information collected during the research and the experience gained from the illustrated book project, the study highlights the importance of using augmented reality technology in children's literature and provides suggestions to address the shortcomings in this field.
СОВЕТ ИТТИФОҚИ ЙИЛЛАРИДА ЎЗБЕКИСТОНДА МАДАНИЙ ТУРИЗМНИНГ ТУРИЗМ ИНДУСТРИЯСИДАГИ ЎРНИ ВА АҲАМИЯТИ
Authors: Мансуров Музаффаржон
Published: June 2023

Тадқиқот мақсади Совет Иттифоқи йилларида Ўзбекистонда маданий туризмнинг туризм индустриясидаги ўрни ва аҳамиятини очиб беришдан иборат. Даврий чегараси 1924-1991-йилларни ўз ичига олади. Тадқиқот иши қиёсий-тадрижий, даврийлик методлари асосида хориж манбалари ҳамда Совет Иттифоқи йилларида нашр этилган газета ва журналлар асосида таҳлил қилинган. В.А.Квартального, Г.А. Папиряна, B.C. Малышева, Р.Ю. Поповой, О.П. Березкиной, Н.В. Михайловой, И.И.Ильиной. каби олимларнинг анализ методларидан самарали фойдаланилган.
O‘ZBEK TILI ISH YURITISH TERMINLARINING ETIMOLOGIK TAVSIFI
Authors: Saidov O‘lmas
Published: June 2023

Fan-texnika va madaniyatning rivoj topishi, ijtimoiy-siyosiy aloqalarning tobora o‘sib borishi o‘zbek tili ish yuritish terminlari tizimida ijobiy o‘zgarishlarga sabab bo‘ldi. Ayni paytda, terminlarning turli jihatlarini aniqlashtirish masalasini yaqqol namoyon etmoqda. Terminologik tizimlarda mavjud bo‘lgan, tavsiya etilayotgan yoki eskirgan termin o‘rniga almashtirilayotgan yangi terminlarni ilmiy asoslash eng maqbul yo‘l hisoblanadi. Etimologik tavsif qilish orqali o‘zbek tilining ish yuritishga oid terminlarini chegaralab olish ehtiyoji dolzarb masaladir.
“MULLO NASRIDDIN” ‒ TURKIY MATBUOT TARIXIDA MUHIM HODISA
Authors: Yakubova Nilufar
Published: June 2023

Mazkur maqolada Ozarbayjon matbuotida shakllangan maktablar, jumladan, “Mullo Nasriddin”, “Fuyuzot” maktablari haqida, “Mullo Nasriddin” jurnalining turkiy xalqlar matbuoti, xususan, jadid adabiyoti va matbuoti shakllanishidagi o‘rni va uning o‘ziga xos jihatlari haqida ma’lumot berilgan. Shuningdek, ushbu maqolada “Mullo Nasriddin” jurnalining ilmiy ahamiyati borasida fikrlar keltirilgan.
ХАЛҚ ТАЪЛИМИДА МАЪМУРИЙ БОШҚАРУВ ВА МЕҲНАТ МУНОСАБАТЛАРИ БИЛАН БОҒЛИҚ КОРРУПЦИЯВИЙ ОМИЛЛАР ТАҲЛИЛИ
Authors: Абдуллаева Маликабону
Published: June 2023

Мазкур мақолада халқ таълими соҳасида юзага келадиган маъмурий бошқарув ва меҳнат муносабатлари билан боғлиқ коррупциявий омиллар таҳлил қилинган. Мақолада ривожланган хорижий мамлакатлар олимларининг мазкур мавзуга оид илмий қарашлари ҳамда фикр-мулоҳазалари ўрганилиб, уларга нисбатан муаллифлик қарашлари билдирилган. Шунингдек, амалга оширилган тадқиқот натижасига кўра илмий хулосалар ишлаб чиқилган.
OILA VA NIKOH SHAROITIDA AYOLLAR SPORTINING MUAMMOLARI
Authors: Umarov Abdusamat , Xojimurodova Mahliyoxon
Published: June 2023

Ushbu maqolada ayol sportchilarni nikoh munosabatlarining ichki jihatlari, oiladagi gender rollarining taqsimlanishi, sportchilarda gender xulq-atvorining kundalik jihatlari mavjud statistik ma’lumotlardan kelib chiqqan. Bir qator olimlart tomonidan keltirilgan ma’lumotlar tahlili yoritilgan.
Kuzey Afrika İbâdiyye’sinde Kelâmî Düşünce
Authors: BENRAS Mahmoud
Published: June 2023

İbâdiyye, köken itibariyle ilk İslâm mezheplerinden olup günümüze kadar varlığını koruyabilen az sayıdaki İslam mezheplerinden biridir. İbâdiyye mezhebi günümüzde Umman Sultanlığı, Kuzey Afrika ve Tanzanya gibi farklı bölgelerde yaşam alanı bulmaktadır. Ancak İbâdîler ile ilgili yapılan araştırmalar diğer mevcut ve mensubu kalmamış fırkalara nazaran daha az sayıdadır. İbâdiyye, hicri birinci yüzyıla kadar dayanan ve büyük fitne olayları diye bilinen hadiseden sonra ortaya çıkan bir gruptur. Bu grup ilk dönemde Hâricîlerin yanında yer alırken zamanla siyasi ve düşünce yapısı itibariyle onlardan ayrılmıştır. Hâricîler erken dönemden itibaren tarih sahnesinden silinmelerine rağmen İbâdîler bugüne kadar varlıklarını sürdürmeyi başarmışlardır. Fakat birçok araştırmacı, İbâdîlerin hâlâ Hâricîlerin bir kolu olarak varlıklarını sürdürdüklerini düşünmektedir. Bu makalede Kuzey Afrika İbâdîlerinin kelâmi düşünceleri ele alınmıştır. İbâdîler genel olarak Hâricîlerden siyasi ve ideolojik olarak ayrılmışlardır. Özel olarak Kuzey Afrika İbâdîleri, Hâricîlerden ve aynı zamanda genel İbâdîlerden farklılıklarıyla ayırt edilmektedir. Bu farklılıkların özlerini anlayabilmek için arkasında duran ve yol gösteren düşünceyi tespit etmek gerekir.
The association of family functions in families of children who undergo organ transplantation: the quality of life of the children and their families
Authors: DÜKEN Mehmet Emin , YAYAN Emriye Hilal
Published: June 2023

Aim: Family functioning and quality of life are related. This study was to examine the association of family functioning in families of children/adolescents who had undergone organ transplantation and the quality of life of these children/adolescents and their parents. Methods: This descriptive cross-sectional study collected research data using the following tools: Child Information Form, Parent Information Form, Pediatric Quality of Life Questionnaire, Parent Quality of Life Assessment Scale, and Family Assessment Device. Results: This study found that the quality of life mean scores of children and parents were low. There was a positive relationship between the general quality of life of children who underwent organ transplantation and their psychosocial quality of life and the quality of life of their parents. This study also found a negative relationship between the psychosocial quality of life of children who had undergone organ transplantation and the subdimensions of roles, affective responsiveness, behavioral control, and general family functioning. Conclusion: This study showed that the quality of life levels of children who have undergone organ transplantation and of their parents may be low and may be associated to each other, which may lead family functioning to be negative.
Annals of Clinical and Medical Case Reports
Authors: Peng LI
Published: June 2023

1.1. Objective: Gitelman syndrome (GS) is an autosomal recessive tubular disorder characterized by metabolic alkalosis, hypokalemia, hypomagnesemia and hypocalciuria. GS is mostly caused by inactivating mutations of the SLC12A3 gene. The purpose of this study was to describe the clinical features of a GS patient and investigate the underlying mutations of SLC12A3 gene in the pedigree. 1.2. Methods: A patient suffering from muscle weakness was clinically diagnosed as GS. Clinical data of the proband were studied retrospectively. All of his family members were screened for SLC12A3 gene mutations. 26 exons and exon-intron boundaries of SLC12A3 gene were amplified by Polymerase Chain Reaction(PCR). PCR products were sequenced directly. 1.3. Results: The proband had hyperreninemia but hypoaldosteronemia, which was distinct from the cases previously reported. The proband and his sick brother were found to have the same compound heterozygous mutations (c.917C>T and IVS 14-8T>C) of SLC12A3 gene. Each mutation was detected in paternal and maternal genomic DNA, respectively. The proband’s healthy brother had one mutation (c.917C>T) only. IVS 14-8T>C was a novel splicing site mutation that had never been reported. 1.4. Conclusion: Hypoaldosteronemia was found in a GS patient. A novel heterozygous splicing site mutation of the SLC12A3 gene was reported, expanding the spectrum of SLC12A3 gene mutations.
UNVEILING USER GRATIFICATIONS SOUGHT FROM UTILIZING EMAIL IN INSTITUTIONAL SETTINGS: EVIDENCE FROM NIGERIAN ACADEMIC STAFF
Authors: Anumudu Chinedu Eugenia
Published: June 2023

Gratification is the basic motive behind using any communication technologies for interactions, especially among the institutional members as a corporate entity. However, it is an ironic scenario in emerging societies such as Nigeria since there is a lack of studies on the specific gratifications that could buttress the use of email as one of the predominant mediums for enhancing institutional communications. Thus, this study explicitly investigated the gratifications sought in utilizing email in institutional settings by the Nigerian academic staff. The study also explored the types of email addresses mostly preferred for conveying salient information among the Nigerian academic staff. Hence, a qualitative paradigm through the interview approach was employed in this study for soliciting their views on these phenomena. Consequently, the study demonstrated that most of the interviewees prefer to use a personal email address for various reasons. With regards to the gratifications sought in using email, three motives emerged and these were students’ integrative needs, bridging distance needs; and self-career development needs. Therefore, it is recommended that they should unequivocally utilize email for gratifying these motives if they anticipate harnessing other institutional mediums of communication. The findings further proffer insights into factors that could enhance virtual media gratifications, particularly asynchronous ones.
Effect of Seven-contact Breastfeeding on the Knowledge, Motivation, and Ability of Breastfeeding during the First Eight-weeks Postpartum
Authors: Siregar Farida Linda Sari , Nasution Siti Saidah
Published: June 2023

Introduction: A minimum of seven-contacts with health personnel is required to successfully breastfeed for six months exclusively. Furthermore, non-exclusively breastfed babies have a six-fold risk of dying in the first year, increased susceptibility to disease, and cognitive loss. This study aims to determine the effect of the seven-contact program on the knowledge, motivation, and mothers’ ability to breastfeed at 8 weeks postpartum. Methods: A quasi-experimental study was conducted from July to December 2020. About 37 samples of mothers with a gestational age of 28 weeks at the Maternity Clinic in Medan were selected using the purposive sampling technique. The data were obtained from the questionnaires and observation sheets and analyzed using the paired t-test. Results: The results showed that knowledge, motivation, and mothers’ ability to breastfeed were significantly different before and after the seven-contact breastfeeding intervention with a p-value of 0.001<0.005. Conclusion: Seven-contact breastfeeding intervention increases pregnant women’s knowledge, motivation, and ability to breastfeed during the first eight weeks after delivery. Therefore, it is necessary to encourage pregnant women to apply the Seven-contact Breastfeeding to improve and support their journey.
Malaria and Its Prevention: Socio-acceptability in the Application of Insecticides-treated Bed Nets Among Household Heads in the Rural Village Community of Mazabuka, Zambia
Authors: Banda Jane , Ithnin Nur Raihana , Osman Malina , Awang Hamat Rukman
Published: June 2023

Introduction: Malaria poses immerse public health challenges in the world as it is still causing significant morbidity and mortality especially in endemic regions such as Zambia. One of the effective tools in preventing malaria is the application of insecticide-treated bed nets (ITNs). This study aims to explored the socio-acceptability of malaria and ITNs among rural village community of Mazabuka, Zambia. Methods: A semi-structured questionnaire was administered to 177 respondents via two different approached methods; focus group discussions and one-to-one interviews to assess the level of KAP of the respondents about malaria and ITNs. Results: Most of the respondents (98.7%) possessed ITNs that were provided free of charge by the Ministry of Health Zambia. Overall, the knowledge and attitude of respondents on malaria and ITNs were at moderate levels of 68.1% and 71.8%, respectively. In contrast, the level of practice was poor with only 36.2% of positive response. Although 92.1% of the respondents answered correctly on the association between malaria and mosquito bites, myths and misconceptions were still common as some of them still attributed malaria to drinking dirty waters (32.8%), bad weather (15.8%), witchcraft (3.4%), and bathing dirty water (19.8%). The practice was significantly associated with knowledge (p=0.003), but not attitude (p=0.230). Logistic regression analysis revealed that respondents with high knowledge level and tertiary education were more likely to use ITNs correctly (OR=2.957; OR=21.739, respectively). Conclusion: The present study showed that the knowledge gaps were remained among the villagers as misconceptions and their believe of myths were still exist.
Reproductive Health Education Using Interactive Learning Approach among the University Students
Authors: Abdel Rahman Rania , Abuidhail Jamila , Abujilban Sanaa , Mrayan Lina , Ashour Ala’a , Nsairat Shawkat
Published: June 2023

Introduction: This study objectives were to evaluate the youth’s knowledge and awareness of reproductive health issues among the Hashemite University students and to measure the effectiveness of the interactive teaching approach in delivering the reproductive health knowledge course. Methods: Quantitative and qualitative research designs were used. The sample was 160 (two cohorts) undergraduate students who enrolled in the reproductive health course during two semesters at the Hashemite University. Quantitative data was collected from the students before and after receiving a reproductive health course. Qualitative data was collected through focus group discussions. Results: The study results showed an improvement in the reproductive health awareness level of students. There was a statistically significant increase in the total score of knowledge between the pretest (M = 19.97, SD = 3.89) and posttest (M = 21.65, SD = 4.03) for the first cohort at p =.00. There was a statistically significant increase in the total score of knowledge between pretest (M = 19.33, SD = 2.89) and posttest (M = 20.66, SD = 5.78) for the 2nd cohort at p =.00. Qualitative data revealed that the students were very interested in the reproductive health course and found it very useful for themselves, their families, friends, and society. Conclusion: The interactive learning approach was useful in teaching reproductive health course and increased university students’ awareness regarding reproductive health topics, which were important for students. It was recommended by students to teach reproductive health course to other students in all universities using interactive learning.
Randomised Clinical Trial of Combined L-Carnitine Supplement and Exercise on Biochemical Markers and Exercise Performance: A Systematic Review
Authors: Samsudin Norsuriani , Ahmad Nur Syamsina , Ooi Foong Kiew , Abdul Kadir Azidah , Kassim Nur Karyatee
Published: June 2023

Aim and design: L-carnitine supplementation combined with exercise may enhance metabolic responses and improve exercise performance. Thus, this systematic review article aims to identify the effects of the L-carnitine supplement on biochemical markers, and exercise performance when combined with exercise. Data Sources: The articles are screened and reviewed based on titles, abstracts and keywords. Only peer-reviewed studies written in the English language, dated January 2000 to March 2021, were considered in this review. Review Methods: The PRISMA method is used for this study. PubMed, EBSCOHost, SpringerLINK, and Scopus databases were used to systematically search. Results: From a search 731 articles, 12 articles were identified related to effect of L-carnitine intake with exercises on biochemical markers and exercise performance. Studies showed that L-carnitine supplementation can be consumed daily during aerobic or anaerobic exercises by different population including patients. Its combination could improve serum lipid profiles, antioxidant properties, markers of metabolic, oxidative stress, and inflammatory, and exercise performance. Conclusion and Impact: This review provides information regarding the beneficial effects of L-carnitine supplement with recommended dosages and exercise prescriptions on overall body health in human.
Measurement of Maximum Occlusal Force Using Digital Occlusal Force Measurement Device: A Scoping Review
Authors: Mazlan Mohd Khairul Firdaus , Mahmud Melati , Ahmad Rohana , Lim Tong Wah
Published: June 2023

The aim of this review was to provide an update on the current status of digital occlusal force measurement devices, as well as clinical and research applications in complete arch maximum occlusal force measurement. SCOPUS, ScienceDirect, and PubMed databases were used to conduct a literature search from January 2001 to January 2021. Identification and screening of literature were done independently according to published guidelines and selection criteria. The electronic searches turned up 394 articles, 16 of which met the inclusion and exclusion criteria and were selected for study analysis. All of these studies used T-scan and Dental Prescale digital occlusal analysis system with pressure-sensitive foils as occlusal force measurement devices. The devices showed a promising potential for identifying and comprehending maximum occlusal forces objectively. According to the current review, maximum occlusal force measured with digital occlusal force devices can be used as a prosthodontic adjunct to address issues that arise during the treatment of occlusal disorders, temporomandibular disorders, and complete dentures. It is also useful in predicting cognitive and functional decline in the elderly.
Application and Modification of RT-LAMP for Rapid Detection of SARS-CoV-2 Viral Genome
Authors: Che Mohamad Nor Adibah , Mohd Zain Zainiharyati , Ahmad Noorden Mohd Shihabuddin
Published: June 2023

COVID-19 outbreak caused by the newly discovered SARS-CoV-2 has become a major public health threat around the world and has create a tremendous effect on the global economy. Hence, there is a high demand for rapid and accurate diagnosis to contain the spread of the disease. The Reverse-Transcription Polymerase Chain Reaction (RT-PCR), the current standard for diagnosis of COVID-19 however possesses certain drawbacks that limits its application to meet the high demand of the continually increasing COVID-19 cases. Conversely, Loop-Mediated Isothermal Amplification (LAMP) is another nucleic acid amplification method that shows a great potential as an alternative tool in rapid diagnosis of COVID-19 due to its simplicity and rapidity. This review summarized the recent published research articles related to the application and modification of RT-LAMP assay for the rapid detection of COVID-19 in comparison with other available diagnostic methods.
Noise Exposure Among Motorcycle Riders: A Scoping Review
Authors: Razali Ailin , Rahman Roslila
Published: June 2023

This scoping review aimed to determine the dosage of noise exposure among motorcycle riders and the sources contributing to a rider’s noise exposure. A systematic search of several scientific databases was conducted from 1981 until 2021. Eligible articles were included into the defined criteria. The dosage of noise exposure, sources, and standardization method were extracted. A total of 37 studies were included. There was scarce publication regarding the exact level of noise exposure experienced by the riders. There was, however, abundant evidence on indirect sources of noise exposure for riders, which requires further critical analysis. The dosage of noise exposure among riders was significantly higher than the recommended level. Seven sources were determined to generate noise which could potentially affect the riders, presented in this paper along with their respective evidence.
Impact of a Mobile Health Intervention to Support Exclusive Breastfeeding: A Scoping Review
Authors: Te Ku Nor Tengku Fatin Nadhirah , Wee Bee Suan
Published: June 2023

Nowadays, mobile health (mHealth) intervention has become a popular and convenient strategy to support exclusive breastfeeding (EBF). However, the effectiveness of the mHealth intervention on this topic is still ambiguous. Thus, a scoping review was done to map the available evidence and identify the impact of mHealth interventions to support EBF. A scoping review of English academic journals was conducted using four electronic databases (Scopus, EBSCOHost, Google Scholar, and Science Direct) from 2016 to 2021. Only 23 articles were eligible. The sample size ranged from 50 to 1,568 participants, aged 18 and above. About 60% of the reviewed articles showed that mHealth interventions had a significant impact on EBF. The intervention group that received the mHealth tools had longer and higher EBF rates and duration compared to the control group. Other articles did not find a significant mHealth intervention impact towards EBF; however, it increased breastfeeding efficacy, mother’s knowledge and the child’s body weight.
Effectiveness of Malaria Free Zone Program on the Knowledge, Attitude and Practice of Malaria Prevention among university students in Conakry, Guinea: Protocol of a Randomized Controlled Trial
Authors: Sano Aicha , A/P Sivaratnam Dhashani , Ahmad Norliza , Camara Alioune , Lim Poh Ying
Published: June 2023

Introduction: Malaria is a vector-borne disease caused by the bites of infected female mosquitoes that transmit the parasite to humans. In Guinea, the entire population is at risk of malaria infection. The objective of this study is to develop, implement and evaluate the effectiveness of the Malaria Free Zone program using the Health Belief Model (HBM) to improve malaria prevention knowledge, attitudes, and practices among university students in Conakry, Guinea. Methods: The study design is a clustered randomized controlled trial (RCT). Students are selected using the clustered sampling method, with each university representing one group, either the intervention or control group. The sample size is 113 university students from each group. The content of the Malaria Free Zone program includes eight sessions, which are based on the HBM constructs. This program takes approximately 6 hours and 30 minutes to complete. Respondents are required to complete a questionnaire over four time points. Generalized Estimating Equation (GEE) will be used to determine the effectiveness of the Malaria Free Zone program on malaria prevention knowledge, attitudes, and practices, adjusted with covariates. Conclusion: It is expected that there will be a significant difference in knowledge, attitude, and practice of malaria prevention in the post-test, 2-week and 2-month follow up of the intervention group after the Malaria Free Zone program. Students in the intervention group will have significant higher knowledge, attitude and practice of malaria prevention compared to students in the control group.
Pregnancy-Associated Spontaneous Coronary Artery Dissection: A Case Report and the Lessons from Practice
Authors: Tan Wei Ming , Chuan Julian Tey Hock , Ramaiah Asri Ranga Abdullah , Solehan Hana Maizuliana , Samad Sarah Zulaikha , Sia Koon Ket
Published: June 2023

Pregnancy-associated spontaneous coronary artery dissection (P-SCAD) is one of the fatal conditions that most commonly causes pregnancy-associated myocardial infarction. We herein report a case of P-SCAD in a 26-year-old multigravida woman, who complained of angina postpartum with raised cardiac biomarkers and transient ST-segment elevation on electrocardiograms. We emphasize the importance of a high degree of suspicion in the diagnosis of P-SCAD, together with the common presentation, the management approach, and its psychological impacts on the patients.
Study of Knowledge, Motivational Factors, and Potential Barriers Concerning Blood Donation Between Lapsed and Regular Blood Donors
Authors: Hassan Azizul , Mohd Shariff Noorsuzana , Abdul Kadir Siti Nadiah , Tuan Din Sharifah Azdiana
Published: June 2023

Introduction: Many countries struggle to supply enough blood while maintaining their quality and safety. Increasing the number of regular donors is expected to increase the donor pool and blood safety. Thus, this study describes lapsed and regular blood donors’ characteristics, knowledge, motivation, and barriers concerning blood donation.Methods: This observational cross-sectional study has adopted an assisted self-administered questionnaire, which was distributed to blood donors at the Department of Transfusion Medicine, Hospital Sultanah Bahiyah, Kedah. A total of 328 participants consisting of 164 lapsed and 164 regular donors were selected. Logistic regression tests were used to determine the factors that predict lapsed donors. Results: Out of the selected 328 respondents, 54.3% were in the 25–39 age group, 66.2% were males, and 85.1% were Malays. Most of the respondents (88.4%) showed adequate blood donation knowledge, and 99.7% cited altruism as a motivator for blood donation. About 47.0% of the respondents claimed they lack enough time as their donation barrier. Donors who were younger in age, had a moderate blood donation knowledge (adjusted OR, 3.60; 95% CI, 1.34-9.64), didn’t know where to donate (adjusted OR, 2.79; 95% CI, 1.47-5.29), lack enough time (adjusted OR, 1.83; 95% CI, 1.04-3.24), and insufficient information about blood donation campaigns (adjusted OR, 2.19; 95% CI, 1.23-3.91) were more likely to lapse. Conclusion: Donor education, convenient time and location, and sufficient information about blood donation campaigns targeted at young donors are critical for preventing lapsed donors, which could subsequently increase the regular donor pool.