bluuebunny/crossref_metadata_2025 huggingface dataset:
APPLICATION OF PROTEOMIC TOOLS: THE AUTOLYTIC CHANGES OF PORK MUSCULAR TISSUE
Authors: Chernukha Irina M. , Akhremko Anastasiya G.
Published: January 2019

Eight protein substances that undergo changes during autolysis were found using the electrophoretic methods with the following mass spectrometric identification. The revealed protein substances have different origin: structural proteins (fragments of troponins T and myosin light chains), and metabolic proteins (creatine kinase, pyruvate kinase and alpha-enolase). The decomposition of the fractions of fast skeletal muscle troponin T in 28.0 kDa, 27 kDa and 26.5 kDa was most pronounced.

Identification of constitutive proteins and detection of the products of post — mortem degradation of protein molecules make them suitable candidates for meat quality markers and the following study of these specific fragments will lead to better understanding of the proteolytic activities that take part in the post mortem muscle transformation into meat.
RESEARCH OF AROMA FORMED COMPONENTS OF RENNET CHEESES
Authors: Pochitskaya I M. , Laktionova A. P. , Roslik V. L.
Published: January 2019

The results of the study of the composition of volatile compounds of rennet cheeses are presented. Sample preparation was performed using Supelco’s solid-phase microextractor, including a special fiber material coated with a layer of divinylbenzene-carboxene-polydimethylsiloxane «DVB / Carboxen / PDMS StableFlesh ™». Using gas chromatography with mass-selective detection, about 400 aroma-forming components were detected, among which 39 compounds were identified, which form the basis of the flavor profile of cheeses. The main flavor descriptors for all cheeses are: propionic, butyric, and caproic acids, acetoin, methyl amyl ketone, 2-nonanone, and limonene. It has been established that the profile of volatile components for cheeses various ripening periods, has significant differences. Thus, for semi-hard cheeses made using propionic acid microorganisms, the most characteristic components are acids — propionic and butyric, as well as compounds of the terpene series o-cymene and β-pinene. For semi-hard cheeses of the Dutch group (formed from the layer), with maturities from 20 days to 3 months, the terpene compounds and esters are the most significant, whereas for superhard cheeses with a maturity of more than a year, the main components affecting the aromatic profile are butyric and caproic acids, 2-heptanone and limonene. Semi-hard and hard cheeses with ripening periods from 3 to 6 months are characterized by a high content of caproic and butyric acids, as well as by the presence of such aromatic substances as limonene and acetic acid ethyl acetate (hexyl acetate). Semi-hard cheeses, which are molded in bulk, with maturities from 10 days to 3 months contain acetoin, caproic acid, as well as significant quantities of the same limonene and hexylacetate.
IFLUENCE OF FUNCTIONAL FOOD PRODUCT ON SERUM FATTY ACID COMPOSITION IN HYPERLIPIDEMIC RATS
Authors: Chernukha I. M. , Kotenkova E. A.
Published: January 2019

A special area in the rapidly growing range of food products is occupied by specialized and functional products, especially for certain categories of citizens. In addition to confirming their biocorrective properties, it’s necessary to balance protein, fat and carbohydrates contents as well as the availability of essential nutrients. The developed meat product based on porcine hearts and aorta was characterized by a high protein content (17.53±0.95%), with a low fat content (3.82±0.13%), the atherogenic index was 0.43. According to in vivo study results, it was shown that the introduction of developed product during 42 days into the diet of hyperlipidemic rats lead to a decrease in the relative content of saturated fatty acids by 21.1%(P<0.05), mainly due to palmitic fatty acid reduction by 42.0% (P<0.05) compared with the control. The observed modifications of serum fatty acid composition resulted in the reduction of atherogenic index by 43.3% (P<0.05). The revealed positive dynamics of lipid metabolism recovery in hyperlipidemic rats makes it possible to recommend the developed product as a component of diet therapy, concomitant to the main treatment, for persons with risk of cardiovascular diseases, in particular, due to dyslipidemias.
Febrile seizures: what pediatricians should know
Authors: Belousova E. D.
Published: January 2019

Febrile seizures are the age-dependent and predictively favorable condition, which is observed in children under 6 years. All febrile seizures are divided into simple (2/3 of all cases), complex and febrile status. Complicated seizuresinclude attacks with focalsymptoms, prolonged and recurring throughout the day. Simple febrile seizures are short, generalized, not repeated. Simple seizures do not harm the child’s neuropsychic development, they do not transform into epilepsy, and do not need chronic prescription of anticonvulsant therapy. A child with normal development and simple febrile seizures does not need an obligatory EEG and MRI of the brain. All the patients of 18 months old or less with the first episode of febrile seizures need to be hospitalized. The risk of recurrence of seizures and their transformation into epilepsy is higher in a child with complex seizures. There is a small group of children with prolonged seizures and / or febrile status, often with neuropsychiatric developmental delay, which needs to be monitored by a neurologist and further examination. Sometimes doctor prescribes long-term anticonvulsant therapy for the children of this group. Febrile seizures can be prevented with special dosage of anticonvulsant drugs quickly reaching a therapeutic concentration in the child’s brain. Febrile seizures are not a contraindication to vaccination and revaccination, attention should be paid in case of DTP vaccination in children with repeated prolonged seizures and / or febrile status.

Conflict of interest: The author of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Characteristic of clinical syndromes in patients with primary defects in antibody production
Authors: Khakimova R. F. , Luntsov A. V. , Skorokhodkina O. V.
Published: January 2019

Primary immunodeficiency is a rare disease with a high medico-social significance. Objective: to characterize principal clinical syndromes in 35 patients from 12 to 37 years old with primary immunodeficiency associated with an abnormal antibody production. The infectious syndrome is the most significant syndrome, it was revealed in all the patients, in some cases it was combined with autoimmune, atopic and lymphoproliferative syndrome. Thus, there isthe need to inform physicians of variousspecialties about this pathology. 

Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Medical care for children with cancer in the Central Federal District
Authors: Rykov M. Yu.
Published: January 2019

Relevance. Statistical indicators are the basis for planning of the organization of medical care for children with cancer, as well as analysis of the effectiveness of medical care. Materials and methods. The authors have analyzed operational reports for 2017 of the executive authorities in the field of health care of 18 objects of the Russian Federation being part of the Central Federal District. Results. There 9 pediatric oncology departments, there are 464 children’s oncological beds, the bed occupancy per yearis 319.3. There are 91 doctors providing medical care to children with cancer, 64 (70.3%) of the doctors have a certificate of pediatric oncologist. In 11 subjects there are no Departments for Pediatric Oncology. There are 821 primary patients with malignant neoplasms. There are 156 deceased patients, 66 of them were diagnosed in 2017. 52 (6.3%) patients are revealed actively. There were 12 (per 100 thousand for the age group of 0–17 years) cases of incidence of malignant neoplasms, mortality is 2.3 (per 100 thousand for the age group of 0–17 years), one-year mortality is 8%. The average time taken to diagnose and to verify the diagnosis before the beginning of treatment remains unknown. Conclusion. Operational reports contain non-matching indicators, thus, the information is not completely reliable. Incidence rates are significantly lower than those in countries with high reliability of statistical data. The percentage of patients identified actively remains extremely low. In order to eliminate the noted defects, it is necessary to introduce a single database of children with cancer in the Russian Federation.

Conflict of interest: The author of this article confirmed the lack of conflict of interest and financial support, which should be reported.
Neonatal lupus
Authors: Makarova T. P. , Vakhitov Kh. M. , Firsova N. N. , Melnikova Yu. S. , Novitskaya T. A.
Published: January 2019

Neonatal lupus is a complex of symptoms diagnosed in newborns whose mothers suffer from autoimmune rheumatic diseases; it is manifested by two main signs: diseases of the skin and heart. A newborn may have classic ring-shaped erythema, telangiectasia, skin atrophy, follicular plugs and scales. This skin lesion is usually combined with a partial or complete heart block due to fibrosis of its pathways. There is a Clinical case of a child with neonatal lupus from own practice.

Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.
A STUDY ON TURKI HOOR, TURKISH BEAUTY
Authors: KUYUMCU Hakan
Published: January 2019

Having come under the influence of Parsi/Persian during the First World War, The Urdu Theater and especially Bombay Parsis established numerous itinerant Natak theater companies such as Victoria, Original, Alfred and New Alfred. Initially, Parsi playwrights wrote plays for these companies and Urdu playwrights/authors after 1880 and poets began to join them. One of the prominent playwrights of the time, Agha Hashr Kashmiri (1879-1935) began to write plays with a decision he took after a harsh dialogue he had with Mehdi Hasan, another playwright who he met in Benares. Kashmiri’s plays are dominated by a colorful imagination, humor and rhetorical power rather than an exaggerated poetic style. With a conscious effort, he raised people’s tastes and standards. It is these qualities of his that distinguished him from his colleagues. His famous plays include Turki Hoor, Esir-e Hırs, Shahidnaz, Yahudi ki Larki, Khab-e Khasti and Rüstem u Suhrab. The theater remained inactive for a long time as a branch of art not favored by Muslims in the Indian sub-continent. However, with the arrival of the Western people, it became a favorite branch of literature in the sub-continent again. Muslims, too, regarded this genre as the best means of reflecting their feelings and ideas to the people. They tried to treat many topics connected with the Ottoman State and its cultural structure through drama especially at the beginning of the Caliphate Movement process and afterwards. Turki Hur is one of the fine examples of these works. In this article drama written by Agha Hashr Kashmiri is analyzed technically and presented to the attention of the Turkish and World Theater enthusiasts.
SİYASETNÂMELERDE DİN DEVLET İLİŞKİSİ
Authors: ADALIOĞLU Hasan Hüseyin
Published: January 2019

Din ile devlet arasındaki ilişkinin insanlık tarihi kadar eski olduğunu söyleyebiliriz. Bu ilişkinin, tarihin değişik dönemlerinde farklı şekillerde ortaya çıktığı görülmüştür. Tarihî olarak başlangıçta, tek iktidar alanı ‘din’ görülürken, toplumsal örgütlenmenin gelişmesiyle siyasal güç ‘devlet’ önem kazanmış ve dinden ayrı bir iktidar alanı olarak ortaya çıkmıştır. Bu dönemden sonra, kimi zaman devlet dini kontrol ederken, kimi zaman din devleti hâkimiyeti altına almıştır. Kimi zaman da aynı toplumda iki farklı iktidar olarak birbirlerine müdahale etmeden yaşamaya çalışmışlardır.İslam siyaset geleneğinde, Batı’dakinin aksine din ile devlet arasındaki ilişkiler, daima müsbet olmuştur. Devletin vazifesi, insanlar arasındaki uyumu tanzim etmek; dinin görevi ise, iman, ahlak ve hukuk esası üzerine yardımlaşmayı temin etmektir. Siyâsetnâmeler, din devlet ilişkileri konusunda her iki kurumun birbirine rakip ve ayrımcı olmasını değil, birbirini tamamlayan, bütünleştirici olmasını savunurlar. Din ile devletin ikiz kardeş olduğu, dinin temel; devletin ise, o temeli koruyan asker olduğu, her ikisinin birbirinden ayrılamayacağı ilkesi genel kabul görmüştür.
OSMANLI ARŞİVİ BELGELERİNDE İRLANDA İHTİLALİ
Authors: TEMEL Mehmet
Published: January 2019

XII. Yüzyılda İngiliz kolonisi haline gelen, XVI. Yüzyılın ilk yarısında da İngiliz egemenliğine giren İrlanda’da, İngiltere’nin siyasi ve ekonomik egemenliğini güçlendirerek sürdürebilmesi için uyguladığı politikalar, Amerika ve Avrupa’da görülen ekonomik, siyasi ve fikri özgürlükler İngiliz egemenliğinden kurtulmayı sağlayacak ihtilal sürecini başlatmıştır.İrlanda’nın bağımsızlık sürecini XVIII. Yüzyıldan itibaren izlemeye başlayan Osmanlı Devleti, adadaki gelişmeleri ve İngiltere’nin İrlanda politikalarını Eflak-Boğdan voyvodalarının kaimeleriyle, Londra’daki diplomatlarının raporlarından öğrenmeye çalışmıştır. XVI. Yüzyıldan itibaren görülen ayaklanmaları mezhep çatışması, fitne-fesat hareketi ve ihtilal ateşi olarak nitelendirerek gelişmeleri izlemekle yetinmiş, insani yardım dışında İngiltere ile ilişkilerini zedeleyebilecek girişimlerde bulunmaktan kaçınmıştır.İrlanda’nın bağımsızlık isteklerine karşı XIX. Yüzyılın ortalarına kadar sertlik politikası izleyen İngiliz hükümetleri, 1880’li yıllardan itibaren uzlaşmacı politikalara yönelmişlerdir. Özellikle Liberal Parti’nin iktidara geldiği dönemlerde yapılan müzakereler sonucunda Güney İrlanda 1921 yılında bağımsızlığını elde etmiştir. Bu makalede İrlanda’nın, XVIII. Yüzyılın sonlarında başlayıp XX. Yüzyılın başlarında bağımsızlıkla sonuçlanan ihtilal süreci ve Osmanlı Devleti ile ilişkileri Osmanlı Arşivi belgeleri ve diğer kaynaklar ışığında incelenmeye çalışılacaktır.
Development of the integrated management system in food production company
Authors: Вайскробова Евгения , Vayskrobova Evgenia , Барышникова Надежда , Baryshnikova Nadezhda , Резниченко Ирина , Reznichenko Irina , Покрамович Людмила , Pokramovich Lyudmila
Published: January 2019

Modern tendencies in food industry development (including meat products processing) are connected with compulsory advance and improvement in production techniques as well as implementation of effective management systems which stem from

the integrated approach to risk management. The development and implementation of the systems which would guarantee required and stable safety of products for consumers are very important as well as their quality. For that reason it is essential to develop the models of integrated management system which will be based on the quality management system (QMS) and food safety management system standards. The authors performed comparative analysis of the requirements of the integrated standards. As a result of the analysis and expert evaluation they determined ten areas of integration, developed the matrix of requirements for the elements of the integrated system. The authors studied the risks, gave scientific evidence concerning the occurrence of potential hazards, determined unacceptable risks, pointed out critical control points and developed food safety management system plan for management in these points. They also determined the regularities in the influence of the quality loop stages on the quality and safety parameters, identified and structured the processes using IDEF0 function modeling methodology, made the blocks of graphs that show the interaction of processes determining the directions of information and product flows and reflecting the interaction of processes. The authors developed an integrated system model and determined the information requirements for its functioning. They used the procedure of the system performance assessment in a company using self-assessment criteria. The authors showed the advantages of the implementation and improvement of the integrated system in the company located in Saransk, the Republic of Mordovia.
Structural and mechanical properties of forcemeat systems based on hydrobionts and poultry of mechanical separation
Authors: Журавлева Светлана , Zhuravleva Svetlana , Бойцова Татьяна , Boytsova Tatiana , Прокопец Жанна , Prokopets Zhanna
Published: January 2019

The article presents the results of the determination of the structural and mechanical properties of one component forcemeats, model systems and combined products based on hydrobionts and poultry of mechanical separation. The authors found out that forcemeat produced from mechanical separation poultry has low shaping ability compared to the forcemeats produced using raw materials of aquatic origin (humpback salmon, navaga, greenling). As for the latter, humpback salmon forcemeat has the best shaping ability. Forcemeats produced from navaga and greenling have satisfactory structural and mechanical properties. Combining raw materials of aquatic origin and poultry of mechanical separation makes it possible to increase relative biological value of the final products. However, introduction of poultry of mechanical separation into fish forcemeats reduces the shaping ability of the obtained combined forcemeat mixtures sufficiently. To enhance their structural and mechanical properties the authors suggested including dried luminaria into their composition. The authors point out that all forcemeat mixtures including 3–5% of dried luminariahave optimum values of water-binding power. This, in its turn, promotes formation of the suitable structure. Introduction of 5% of dried luminaria into the combined mixtures helps reduce weight loss at thermal treatment by 33.3–45.6%. The authors showed that refrigerated storage of forcemeat mixtures which include 5% of dried luminaria for a month at −18°C helps reduce peak load on average by 19.8%, water-binding power – by 14.4%. But that has a negative effect on their shaping ability. The recommended shelf life of the developed forcemeat mixtures and semi-finished products produced on their basis should not exceed 30 days at −18°C.
Development of mayonnaise recipes considering the main trends in product range improvement
Authors: Старовойтова Ксения , Starovoytova Ksenia , Терещук Любовь , Tereshchuk Lyubovʼ
Published: January 2019

The article reveals technological aspects of using different types of egg products in mayonnaise production technology. The authors studied the chemical composition of different egg products being used in mayonnaise production technology. The authors studied egg powder, dried egg yolk, enzymatically hydrolyzed dried egg yolk, salted pasteurized liquid egg yolk, egg mixture, and frozen yolk. Based on the obtained data the authors calculated minimum proportions of egg products which are sufficient for producing high quality mayonnaise which complies with the requirements of the standard. The article reveals the results of the research which show the influence of different types of egg products traditionally used in mayonnaise production technology on the organoleptic, physical and chemical properties of the final product such as its consistency, look, stability of undisturbed emulsion, acidity, oxidative deterioration indicators during storage. Study of organoleptic quality indicators of the produced kinds of mayonnaise showed that introduction of egg products in minimum proportions does not lead to the sufficient changes in taste and color of the obtained products. But the samples which include dried egg yolk have heavier and thicker consistency than the samples with whole egg products. The authors developed the recipes and production technology of different types of mayonnaise with mass fraction of fat equal to 67% using different egg products including dried egg yolk modified by phospholipase. That type of egg yolk modification made it possible to guarantee the required viscosity of the product, emulsion stability as well as homogeneous creamy structure. This allowed to use less egg products but did not influence organoleptic properties of the traditional mayonnaise. The authors studied the quality of the produced mayonnaise and checked their organoleptic, physical and chemical properties on compliance with standard requirements.
Analysis of the ways of anticorrosive influence on food industry equipment protection
Authors: Алмагамбетова Сауле , Almagambetova Saule
Published: January 2019

Nowadays there is a significant engineering and technical issue which is corrosion of structural materials, metal equipment and installations. Inhibitors are one of the effective, universal and economical means of protection against corrosion. The author justifies the relevance of the problem connected with selection of corrosion inhibitors for food industry companies. The aim of the work is to study the effect of inhibitors based on plant raw materials on increasing the corrosion resistance of food industry equipment in technological corrosive media. A literature review showed that the use of synergistic inhibitory compositions is more effective than using inhibiting additives separately. A specified inhibitor is a modified plant raw material. It has biocidal and bactericidal properties that provide for high efficiency of corrosion protection of structural steels in neutral and acid media and is used to improve protective and physico-mechanical properties of coatings. The author studied the effect of concentrate inhibitor in the working environment on the basis of technological regulations to justify recommendations on the use of this concentrate in protecting equipment against corrosion. As a result of the study, the author determined that the greatest effect took place when a modified concentrate inhibitor was used. The plant-based concentrate inhibitor does not have lower corrosion protection effectiveness than the industrial inhibitor PB-5. On the contrary, it has a number of definite advantages such as environmental safety, multiple action directions as well as a positive effect on the sanitary and hygienic conditions in the process of inhibitor preparation and use. The author gives recommendations on the possibility of using this inhibitor to protect the mechanisms used in food industry against corrosion.
Peculiarities of using steam-convection oven for production of bakery products
Authors: Маркова Юлия , Markova Yuliya , Марков Александр , Markov Aleksandr , Романов Александр , Romanov Aleksandr
Published: January 2019

The article presents the results of research on the peculiarities of proofing and baking bakery products using a steam-convection oven for continuous proofing and baking. The aim of the work was to develop recommendations for setting parameters for production of bakery products in the steam-convection oven at continuous proofing of dough pieces and bakery products. For control samples baking the author used a proofing box for final proofing and a convection oven. The analysis of the structural and mechanical properties of crumb was made using device “Strukturometer-1”, and loss of weight after baking was measured using standard methods. Intensity and color uniformity of crust were determined applying an ingenious method using flatbed scanner. Automatic recorder monitored the temperature in the baking chamber and inside the baked dough pieces. To determine the changes in product volume and proportion of the formed crumb during baking process, an original optical method was used. As a result of the research the author determined that there is a dependence of the dynamics of baked dough pieces quality indicators on proofing and baking parameters. It is shown that the main differences are observed during the first baking period. The detected regularities are associated with smooth heating of the steam-convection oven baking chamber and high relative humidity of the medium at the beginning of baking process. When using a steam-convection oven, the crusts had uneven color which is obviously due to condensation of a large amount of moisture on the surface during the initial baking period and, consequently, different rates of heating of individual parts of the crust. By the moment when baking process was over control samples and developed samples had insufficient differences concerning structural, mechanical and physicochemical parameters. It was determined that in case of continuous proofing and baking in steam-convection oven it is necessary to extend the baking process and increase dough humidity compared to traditional baking method.
The possibilities of debtor segmentation algorithmic modeling in the context of commercial lending
Authors: Черниченко Светлана , Chernichenko Svetlana , Котов Роман , Kotov Roman
Published: January 2019

Financial policy of any entity comes down to managing economic parameters and relies on exploration of the strength of relations and dependencies between them. By means of analysis of the given indicators and identification of the degree of their correlation with the basic indicators, financial engineers get vast opportunities concerning economic processes modeling and optimization. Thus, in the sector of commercial credit, which is characterized by the absence of complete Russian procedures that would help assess the risk of the creditor, the study of credit analysis exhibitors system provides the key to the development of modern models and methodological assessment technologies. The present scientific work includes theoretical, methodological, analytical and financial engineering components. The theoretical part has to provide the theoretical basis for the research, reflect the terms and definitions overview and show the development of the basic complex concept – algorithmic modeling of commercial debtor segmentation. The methodological component is devoted to the study of the fundamental principles which help construct the system of analytical indicators and establish their connection with the algorithmic model. The analytical and financial-engineering component of the scientific work which is of fundamental importance (as it reflects the implementation of the research focus), consists of five stages: 1) identification and thematic grouping of the creditor's risk indicators; 2) indicators unification in the form of the commercial debtor segmentation algorithm; 3) algorithmic model testing and performance evaluation; 4) explanation of cause-effect relationships strength between the interpenetrating exponents of the algorithmic model; 5) identification of the most valuable parameters (identifying factors) of credit analysis in the commercial lending sector. Studies were carried out using selected materials taken from Kemerovo Region agricultural companies. Thus, the result of the research is the author's debtor segmentation. The model makes it possible to form risk groups in the commercial lending sector. The analytical structure is based on the combination of key credit risk parameters taking regional and industry specific features of businesses operation into account and justified by strong correlation of the algorithm elements. That helps financial analysts save time and have equivalent effect of credit risk assessment procedure.
The study of pectin influence on the change in viscosity and color of beverages with natural colourants during storage
Authors: Кукин Михаил , Kukin Mikhail
Published: January 2019

Production of functional foods containing such functional ingredients as pectin and anthocyanins is particularly important nowadays. The goal of the given research was to study the effect of high esterified pectin obtained from apples at a dosage of 0.3% on the changes of viscosity and color of drinks based on cherry juice and anthocyanin colourant obtained from black carrot, apple juice and sugar color IV during storage in a dark place at 22 ± 3 °C for 180 days. Optical density was measured using spectrophotometric method at a wavelength of 350 to 700 nm. Mass fraction of solid matter was adjusted using sucrose to reach 10.1 ± 0.7 %, pH for drinks based on cherry juice and anthocyanin colourant obtained from black carrot was adjusted to reach 3.0, and for drinks based on apple juice and sugar color IV – to reach 3.5 in the prepared beverages. The author shows that pectin does not have any significant effect on colour retention in drinks based on cherry juice and anthocyanin obtained from black carrot, and that anthocyanin colourant from black carrots is more stable during storage than the colourant that cherry juice contains. The color of the drinks based on apple juice and sugar color IV without pectin remains almost the same during storage. In the visible spectrum region they have a monotonous graph of the change in optical density, and pectin makes a significant contribution to the final color. It is established that for 180 days of storage kinematic viscosity of the beverages with pectin decreased not more than 12%, that indicates a high level of pectin preservation. According to the results of the research, the author makes a conclusion that the use of pectin to preserve the color of beverages with natural colourants is not practical. It makes sense to use pectin in order to give the beverages functional properties, as well as to increase their viscosity and stability.
BIOGRAPHICAL METHOD IN THE STUDY OF PERSONALITY: METHODOLOGY AND ARCHITECTONICS
Authors: Логунова Лариса , Logunovа Larisa
Published: January 2019

Biographical method is based on the theory of humanistic direction. It involves subjective assessments of facts, social consulting, access to a high level of generalization. In historical science and literary work with biographies it is a traditional genre. In sociology, the study of biographies was formed in the method of the microsociological paradigm of “soft” data analysis. The architectonic of method consists in a flexible construction of chosen techniques and procedures. The paper details the author’s method of analyzing life scenarios. This technique in the structure of the complex biographical techniques helps the respondent understand the tragic eventfulness of their life, to make a choice to change the script. This choice determines the future success of the respondent and their descendants. The conclusions are drawn on the basis of the author’s using the biographical method in studies of the fate of the Siberians and social consulting with clients.
STUDY OF THE TIME SPENT ON DOCUMENTS PREPARATION IN MEDICAL INSTITUTIONS
Authors: Лузгарева Дарья , Luzgareva Daria , Лузгарева Ольга , Luzgareva Olga , Лопатин Андрей , Lopatin Andrey
Published: January 2019

The paper considers the standards of time spent on processing different documents. The example of the Budgetary Public Health Facility of Kemerovo Region “Kemerovo Regional Clinical Drug Dispensary” shows, how much time is required for documents preparation and processing, depending on the document type. In addition, the goal was set to determine the average time spent, as well as to develop recommendations for efficient use of working hours for documents preparation in a medical institution. While analyzing the documents, the formula for calculating the number of people, required for documents processing, was developed, and the relevant calculations were presented.
MARKET RESEARCHES IN THE EDUCATIONAL MARKET: INTEGRATED APPROACH
Authors: Миляева Лариса , Milyaeva Larisa
Published: January 2019

The paper presents the original methodical tools uniting two complementary techniques: creation of a motivational profile of respondents of higher educational institutions (potential entrants and students) and transformational analysis of motives of getting higher education. The results of its approbation in Altai Krai in 2012 - 2015 are provided. The necessity of researching the demand in the informal educational services market is proved; its specific features are unveiled, results of target questionnaire of potential buyers are analyzed. Validity of the use of an integrated approach when carrying out market researches in education market is accented.
THE CONCEPT OF POLITICAL CULTURE IN RUSSIAN POLITICAL SCIENCE
Authors: Омеличкин Олег , Omelichkin Oleg
Published: January 2019

The paper studies the main interpretations of political culture prevailing in Russian political science. Their methodological and theoretical foundations and perspectives in the elaboration of this phenomenon are subject to comprehensive analysis. The author substantiates the necessity of unilateral synthesis of scientific concepts in a systematic theoretical form. Such interpretation of political culture is only possible in the context of the entire political system identifying the peculiarities of its cultural organization and standard and value security. The political culture characterizes this system as a whole, with a special emphasis on its quality status, the established political order, the complex network of political interactions and the process of self-organization of people. The author offers an original conception of political culture as a form of political programming of society and reproduction of political relations in their institutional and subject-activity representation. It is concluded that the functioning of the political sphere of society is motivated, contently programmed, organized and instrumentally ensured by its political culture.
THEORY OF MODERNIZATION OF THE ECONOMY: FROM THE BEGINNING TO THE MODERN UNDERSTANDING
Authors: Леванов Анатолий , Levanov Anatoly
Published: January 2019

The subject of analysis in the article is the process of formation of the theory of economic modernization. The goal is to find out the main regularities of formation and its practical use. Methods of analysis include historical-logical analysis and synthesis. The results of the work are reflected in the following conclusions: modernization theory at its current state is not complete. No definition that would fully reveal the contents of the category has been coined yet, and the main branches of economic science do not pay proper attention to modernization as an independent subject of study. Certain aspects of the modernization of the economy, as subsidiary conclusions, were considered in the studies of economic dynamics, economic growth and cyclicality. The ideas of J. Schumpeter can be important for overcoming this vision of modernization. Synthesis of the main approaches to the theoretical and practical thinking on modernization allows one to distinguish the broad and narrow meanings. If the first of these meanings refers to the development and transformation of the entire social order, the other is the development of one of the spheres of social activity. Among the application areas of contemporary modernization of the Russian economy, the market-liberal model and the new (second) industrialization of the country can be pointed out. But both can be implemented only as an organic unity. The results of the study can be used in teaching of macroeconomics , in determining the strategy for the development of the economy as a whole and at the regional level.
Irrigation management techniques with anaerobic baffled reactor effluent: effect on rice growth, yield and water productivity
Authors: Busari T. I. , Senzanje A. , Odindo A. O. , Buckley C. A.
Published: January 2019

The study evaluated the effect of irrigation management techniques using anaerobic baffled reactor (ABR) effluent on the growth and yield of rice. It was hypothesized that irrigation techniques with ABR effluent have a significant effect on the growth, yield of rice, water productivity (WP) and water balance (WB). The experimental setup was a randomized complete block design for 2017 and 2018 cropping seasons, three treatments each with three replications. The treatments were alternating wetting and drying (AWD), continuous flooding irrigation (CFI) and wetting without flooding (WWF). The effect of irrigation management techniques was significant (P < 0.05) for the 2017 season but insignificant (P > 0.05) in 2018 on the yield. The effect of irrigation treatments on WP was significant (P < 0.05). The effects were not significant (P > 0.05) on the plant height, leave area index (LAI) and number of tillers per plant. However, the effect was significant (P < 0.05) on the number of panicles per plant. The effects of irrigation treatments were significant (P < 0.05) on number of irrigation, amount of irrigation, total water use and daily field WB. In conclusion, the result proved the acceptability of the hypothesis. AWD irrigation with ABR effluent should be encouraged among rice farmers.
Continuous-flow ozonation over modified ceramsite: implications for the degradation of cation red x-GRL
Authors: Liu Ying , Wu Deli , He Hongping
Published: January 2019

Catalytic ozonation has been widely used for refractory dye wastewater treatment due to highly reactive HO·. In this study, a kind of low-cost and environmental-friendly modified ceramsite sphere derived from pyrite cinder, silty clay and kaolin was prepared as ozonation catalyst. The degradation performances of cation red x-GRL were performed under a continuous mode. Being close to the practical treatment, continuous-flow ozonation study is vital for applying heterogeneous catalytic ozonation in wastewater treatment at a large industrial scale. Results showed that the absorption capacity of this modified ceramsite towards cation red x-GRL was confirmed to be slight. The mineralization efficiency was high, accounting for 48.0% of 200 mg/L cation red x-GRL at a constant flow rate of 0.18 L/min (hydraulic retention time = 16 min), while only 7.8% during ozonation alone. Furthermore, this novel catalytic ozonation can maintain high mineralization efficiency in a wide range of pH (3–10), which was ascribed to the synergistic catalytic performance of various oxides. The reaction mechanism is ascribed to the promotion of ·OH production from O3 molecules' decomposition. Moreover, ozone utilization efficiency at hydraulic retention time of 16 min during catalytic ozonation was 2.0 times as high as that during ozonation alone.
Rivaroxaban versus Clopidogrel for Peripheral Artery Disease: A Clinico-Economic Approach of the COMPASS Trial
Authors: Tsilimigras Diamantis I. , Moris Demetrios , Karaolanis Georgios , Kakkos Stavros K. , Filis Konstantinos , Sigala Fragiska
Published: January 2019

Peripheral artery disease (PAD) is the third most common manifestation of atherosclerosis after coronary
artery (CAD) and cerebrovascular disease (CVD). People with PAD have plaque findings in other vascular
territories as well and, thus, are at increased risk of major adverse cardiovascular or cerebrovascular events
(MACCE), including myocardial infarction, and stroke. In that context, the COMPASS multicenter, randomized
controlled trial showed that the risk of MACCE was significantly reduced by 24% in the rivaroxaban plus aspirin
arm compared with aspirin alone (4.1% vs 5.4% respectively; HR: 0.76, 95% CI: 0.66 to 0.86). Interestingly, the
rivaroxaban/aspirin arm also showed a reduction in cardiovascular death (HR: 0.78; 95% CI: 0.64-0.96]) and allcause
mortality (HR: 0.82; 95% CI: 0.71-0.96) by 22% and 18%, respectively. Recently, the FDA approved the
use of the dual pathway approach, rivaroxaban 2.5 mg twice daily plus aspirin 75-100mg once daily, to reduce the
risk of major cardiovascular (CV) events, such as CV death, myocardial infarction and stroke, in people with
CAD as well as PAD. In comparing rivaroxaban plus aspirin versus aspirin alone, a preliminary economic analysis
showed that saving per patient was USD 462 for events and USD 220 for procedures with a total reduction of
USD 682 per participant in the US with the combination group (rivaroxaban plus aspirin). The data from COMPASS
trial suggest that low dose rivaroxaban plus aspirin may be a preferred treatment strategy in PAD patients
in whom the bleeding risk is deemed to be favourable.
Current Perspectives in the Application of Medicinal Plants Against Cancer: Novel Therapeutic Agents
Authors: Gezici Sevgi , Şekeroğlu Nazım
Published: January 2019

Background:

Cancer is a disease characterized by uncontrolled cell growth and proliferation. It has become a major health problem in the past decades and is now the second leading cause of death globally. Although, there are different types of treatment such as chemotherapy, immune therapy, radiation, hormone therapy and targeted therapy used against cancer, they have possible side effects and significant deficiencies.

Methods:

This review aims to outline the benefits of medicinal plants and plant-derived products and highlight why they should be used as novel anti-cancer therapeutics. Electronic databases, including PubMed, Scopus, ScienceDirect, Cochrane library, and MedlinePlus were searched to summarize in vitro, in vivo and clinical studies on anticancer effects of medicinal plants and their bioactive compounds up-to-date.

Results:

In recent years, a number of medicinal plants have been administered to cancer patients in order to prevent and treat cancer as an alternative therapy. These plants were used because of their rich anticarcinogenic and chemoprotective potentials. In addition to these remarkable properties, these plants have less toxic anticancer, anti-tumor and anti-proliferation agents than traditional therapeutics. Nevertheless, only a small number of natural anti-tumor products including vinblastine, vincristine, podophyllotoxin, paclitaxel (Taxol) and camptothecin have been tested clinically, while vinflunine ditartrate, anhydrovinblastine, NK-611, tafluposide, paclitaxel poliglumex, combretastatins, salvicine, curcumin, indirubin, triptolide, homoharringtonine are still on trial.

Conclusion:

Consequently, more effective anticancer compounds are identified during the clinical trials; these natural products could be a key source of antitumor agents in modern anticancer therapy. It is expected that novel anticancer phytopharmaceuticals produced from medicinal plants could be effectively used in prevention and therapy for the cancers.
Pubic Rami Fractures Fixation by Interlocking Intramedually Nail: First Clinical Experience
Authors: Ivanov P. A. , Zadneprovsky N. N. , Nevedrov A. V. , Kalensky V. O.
Published: January 2019

Background. Growing number of patients with pelvic fractures is associated with evolution of high-speed transport, high-rise construction and industrial production. The optimal surgical procedure for pubic rami fractures must ensure a stable fixation and simultaneously minimize the risk of postoperative complications. Our aim was to evaluate the efficiency of a new technique for pubic bones fixation by a titanium nail in patients with pelvic fractures.Material and Methods. The authors present the experience on treatment of 18 patients who underwent 25 surgeries for internal fixation of pubic rami fractures by a designed solid titanium nail. Mean age of patients was 40.16±10.35 years. Proposed surgical method provides for mandatory use of image intensifier during all stages of the procedure. With patient in a supine position the authors performed internal fixation of pubic bones by a retrograde nail inserted using a navigating handle through a skin incision of1 cm in the area of symphysis. After complete insertion into the bone the nail was interlocked proximally by two3.5 mm cortex screws through an additional skin incision of1.0 cm using a navigating handle and guiding sleeves. All pelvic ring fractures were classified according to AO/OTA classification and pubic fractures by Nakatani classification. Functional outcome was evaluated by Majeed score.Results. Bilateral fractures were diagnosed in 7 (38.8%) patients (floating pubic symphysis). 13 (72.2%) patients featured polytrauma with average ISS score of 25.1±7.8. 2 (11,1%) patients were diagnosed with open pelvic fractures, 3 (16.6%) patients had a concomitant acetabular fracture. The authors performed epicystostomy in two (11.1%) patients and laparotomy bringing out the drainages in 5 (27,8%) patients. Mean follow up was 7.8±6.2 months. Stable fixation was obtained in all patients. By the moment of the present publication x-ray healing of pubic bones was observed in 16 (64%) cases, in remaining 9 (36%) cases the follow up period was less than mean healing period (2 months). In 11 (68.8%) patients the functional outcome averaged 91±3.9 by Majeed score 6 months postoperatively, in 8 (50%) patients – 93.8±2.9 by Majeed score 12 months postoperatively and more. No complications like skin necrosis, secondary fragments displacement or infection were not observed.Conclusion. Preliminary results demonstrated the absence of wound infection and reliable fragments fixation. This technique can be applied in patients with stomas and drainages upon the anterior abdominal wall which extends the indication range for surgical treatment of anterior pelvic ring. High fixation properties of proposed nailing create conditions for early mobilization of the patients and for conducting the exercise therapy.
Regulatory Concerns about Medical Device Manufacturing Using 3D Printing: Current State of the Issue
Authors: Karyakin N. N. , Shubnyakov I. I. , Denisov A. O. , Kachko A. V. , Alyev R V. , Gorbatov R. O.
Published: January 2019

Custom-made implants, orthotics, orthoses, models for surgical planning and education, and much more are now created using 3D printers. In this article, the authors suiiunarized information on laws and regulations in the domain of legal support for 3D printing of medical devices in Russia and abroad. 3D printing is one of the promising avenues in developing new methods of treatment, so iiiunediate establishing of clear criteria for its legal regulation is necessary. As is, there are still many gaps in the legislative framework. The issues of the quality of 3D models, material standardization and manufacturing processes using 3D printing technologies remain unresolved. When using custom-made medical devices, respecting the rights of patients and preventing the use of prohibited or restricted materials are essential. Yet, legal barriers to this irmovative direction of medicine must be avoided.
La producción de territorios precarios por el dispositivo legal
Authors: Saccucci Erika
Published: January 2019

Este artículo estudia dos conflictos por toma de tierra en la ciudad de Córdoba, Argentina: Piedra Blanca y Pueblos Unidos, a través del análisis de contenido de 56 entrevistas en profundidad. El objetivo ha sido conocer qué tipo de territorio se efectúa, entendiéndolo como el resultado de la intersección entre dispositivos de poder y la agencia de los sujetos. Del análisis se desprende que el principal dispositivo que se despliega sobre los conflictos es aquel legal, frente al cual los sujetos oponen tácticas. En las conclusiones presentamos el territorio configurado que se caracteriza por ser precario.
Program Lansia Sabar Berbasis Reminiscence dan Terapi Seni untuk Menurunkan Kecemasan pada Lansia Penyandang Diabetes Melitus Tipe II
Authors: Puspitasari Errina , Retnowati Sofia
Published: January 2019

This “Lansia Sabar” program which is consisted of reminiscence and art therapy is expected to facilitate the elderly to look back on their lives positively. This programm was administered to nine (9) elderly with type II diabetes mellitus aged 55-70 years who show moderate to severe levels of anxiety. Anxiety level is measured using Beck Anxiety Inventory (BAI). The program lasts for six meetings with a maximum duration of 120 minutes for each session. The experimental design using one-group pretest-posttest with additional double pretest. Data will be analyzed quantitatively using the friedman test, with the additional descriptive data analysis on the results of observation, task book, and the visual inspection. The Friedman test showed Fr(2) = 5,200, p = 0,074 (p > 0,05). It showed that “Lansia Sabar” program has no significant effect to decrease anxiety in the elderly with type II diabetes mellitus.