bluuebunny/crossref_metadata_2025 huggingface dataset:
NILAI-NILAI TOLERANSI DALAM BUKU AJAR SEJARAH KEBUDAYAAN ISLAM KELAS VII MADRASAH TSANAWIYAH
Authors: Hasanah Hijratul
Published: February 2023

In the educational process, the inculcation of values is an important thing that must be implemented to achieve the goals of education itself. One of the values that must be transmitted in the educational process is tolerance. To be able to realize it in life, education must be carried out continuously, both within the school and family spheres. This study aims to determine the values of tolerance in Islamic Cultural History (SKI) textbooks at Class VII Madrasah Tsanawiyah. In this article, the author uses literature or library research, namely studies carried out using literature that originates from books, papers, journal, notes, or reports on research results and previous studies. This study shows that the range of tolerance values found in SKI Class VII textbooks at Madrasah Tsanawiyah include: acknowledging the rights of everyone; respecting the beliefs of others; respecting difference; mutual understanding; as well as awareness and honesty. These values are included in the points of tolerance, democracy, togetherness, equality, and justice.AbstrakDalam proses pendidikan, penanaman nilai menjadi hal penting yang harus dilaksanakan untuk mencapai tujuan pendidikan itu sendiri. Salah satu nilai yang harus ditransmisikan dalam proses pendidikan adalah nilai toleransi. Untuk dapat merealisasikan dalam kehidupan, pendidikan harus dilakukan secara terus menerus baik dalam lingkup sekolah  maupun lingkup keluarga. Kajian ini bertujuan untuk mengetahui nilai-nilai toleransi dalam buku ajar Sejarah Kebudayaan Islam (SKI) di Madrasah Tsanawiyah Kelas VII. Dalam artikel ini, penulis menggunakan studi yang bersifat litere atau kepustakaan (Library Research), yaitu kajian yang dilaksanakan dengan menggunakan literatur yang bersumber baik berupa kitab, buku, karya ilmiah, catatan maupun laporan hasil penelitian dan penelitian terdahulu. Kajian ini menunjukkan bahwa cakupan nilai toleransi yang ditemukan dalam buku ajar SKI Kelas VII Madrasah Tsanawiyah antara lain: mengakui hak setiap orang; menghormati keyakinan orang lain; menghargai dalam perbedaan; saling pengertian; serta kesadaran dan kejujuran. Nilai-nilai tersebut tercakup dalam poin toleran, demokratis/kebersamaan, kesetaraan/kesamaan dan keadilan.
Dimensi Nilai-Nilai Moral dalam Buku Ajar Aqidah Akhlak Kelas VIII Madrasah Tsanawiyah
Authors: Ruhana Ruhana
Published: February 2023

This article aims to map the moral values contained in the textbook on Aqidah Akhlak, Class VIII of Madrasah Tsanawiyah. That is, the writer wants to see the form of moral values, their categorization, and their relevance to everyday life. The method used in this study is library research with the following stages: 1) read the entire Aqeedah Akhlak textbook; 2) mark and categorize moral values, morals, and attitudes; 3) summarize and classify the relevance of moral values to everyday life. This study shows that the moral values in the Aqidah Akhlak textbook for class VIII consist of two main relationships that become the foundation of moral values that are connected to one another, namely: Hablum minallah and Hamlum minan nass. These two categories of relationships give rise to several moral values, namely: 1) Hablum minallah: having faith, and 2) Hablum minan nass: having good prejudice towards others and having compassion. Therefore, it can be concluded that moral values form the foundation for everyday behavior and attitudes that are emphasized by every student in their daily lives. The two foundations of this relationship become an identity for every Muslim.AbstrakArtikel ini bertujuan untuk memetakan nilai moral yang terkandung dalam buku ajar Aqidah Akhlak Kelas VIII Madrasah tsanawiyah. Artinya, penulis ingin melihat wujud nilai moral, kategorisasi dan relevansi dengan kehidupan sehari-hari. Metode yang digunakan dalam kajian ini adalah riset pustaka dengan tahapan sebagai berikut: 1) membaca secara keseluruhan buku teks Aqidah Akhlak; 2) menandai dan mengategorisasi nilai akhlak, moral dan sikap; 3) Menyimpulkan dan mengklasifikasi relevansi nilai moral dengan kehidupan sehari-hari. Kajian ini menunjukkan bahwa nilai moral dalam buku teks Aqidah Akhlak kelas VIII terdiri dari 2 hubungan utama yang menjadi fondasi nilai moral yang saling terhubung satu dengan yang lainnya, yaitu: Hablum minallah dan hamlum minan nass. Dua kategori hubungan tersebut menimbulkan beberapa nilai moral yaitu : 1) Hablum minallah: beriman, dan 2) hablum minan nass, berprasangka baik kepada orang lain, berkasih sayang. Oleh karena itu, dapat disimpulkan bahwa nilai moral menjadi fondasi bagi perilaku dan sikap sehari-hari yang ditonjolkan oleh setiap murid dalam keseharian mereka. Dua fondasi hubungan tersebut menjadi identitas bagi setiap muslim.
Pemetaan Nilai-Nilai Akhlak dalam Buku Ajar Sejarah Kebudayaan Islam Kelas VIII Madrasah Tsanawiyah
Authors: Hasanah Hijratul
Published: February 2023

This article aims to map the moral values contained in the Islamic Cultural History textbook, Class VIII of Madrasah Tsanawiyah. This means that the writer wants to examine in depth the moral values, their categorization, and their relevance to the teacher's role and learning practices. The research method used in this study is a descriptive-qualitative approach with library research methods. The stages of data collection are carried out in the following way: 1) reviewing the contents of the book; 2) categorizing moral values; 3) reducing data by drawing conclusions and their relevance to the teacher's role and learning practices. This study shows that there are 3 dimensions to morality: morals towards God, morals towards teachers and friends, and morals towards oneself. Therefore, it can be concluded that with these 3 moral dimensions, there must be more specific learning practices to be practised by teachers in the preparation, implementation, and evaluation of lesson plans at each meeting.AbstrakArtikel ini bertujuan untuk memetakan nilai akhlak yang terkandung dalam buku ajar Sejarah Kebudayaan Islam Kelas VIII Madrasah Tsanawiyah. Artinya penulis ingin mengkaji secara mendalam nilai akhlak, kategorisasi dan relevansinya dengan peranan guru dan praktik pembelajarannya. Metode penelitian yang digunakan dalam kajian ini adalah pendekatan kualitatif deskriptif dengan metode riset kepustakaan. Tahapan pengumpulan data dilakukan dengan cara sebagai berikut : 1) mengkaji isi teks buku; 2) Kategorisasi nilai akhlak; 3) mereduksi data dengan menarik kesimpulan dan relevansinya dengan peranan guru serta praktik pembelajarannya. Kajian ini menunjukkan bahwa ada 3 dimensi akhlak, yaitu akhlah terhadap Allah, Akhlak terhadap guru, teman dan Akhlak terhadap diri sendiri. Oleh karena itu, dapat disimpulkan bahwa dengan 3 dimensi akhlak tersebut harus ada praktik pembelajaran yang lebih khusus untuk dipraktikkan oleh para guru dalam persiapan, pelaksanaan dan evaluasi rencana pembelajaran pada setiap pertemuan.
Keabsahan Pernikahan Wanita Hamil dengan Pria yang Menghamilinya: Studi Undang-Undang Nomor 1 Tahun 1974 dan Kompilasi Hukum Islam Indonesia
Authors: Muzakkir Muzakkir
Published: February 2023

This paper describes the problem of legal review regarding the validity of a pregnant woman's marriage with a man who impregnates her. The results of the study indicate that a review of Islamic law on the marital status of pregnant women outside of legal marriages, the scholars argue that if a case like this occurs then in this case the marriage is legal under Islamic law, but if there is a marriage of a woman who is pregnant outside of marriage but who marries is a man who did not impregnate her, the scholars have different opinions, some say it is legal, some say it is not valid in their marriage.AbstrakTulisan ini mendeskripsikan permasalahan tinjauan hukum tentang keabsahan pernikahan wanita hamil dengan pria yang menghamilinya. Hasil penelitian menunjukkan bahwa tinjauan hukum Islam terhadap status perkawinan wanita hamil di luar pernikahan yang sah para ulama berpendapat bahwa apabila terjadi kasus seperti ini maka dalam hal ini pernikahannya tersebut sah secara hukum Islam, namun apabila ada pernikahan wanita yang hamil diluar nikah akan tetapi yang menikahi adalah lelaki yang bukan menghamilinya para ulama berbeda pendapat ada yang mengatakan sah ada juga yang mengatakan tidak sah dalam pernikahannya.
In Vitro Inhibition of Growth and Induction of Apoptosis by Mosinone-A in HEp-2 Oral Cancer Cells
Authors: Govindasamy Sugunadevi , Kathiresan Suresh , Rengaraj Gomathi
Published: February 2023

The present study evaluated the influence of a Mosinone-A on the induction of apoptosis in HEp-2 human pharyngeal carcinoma cell lines as evidenced by cytotoxicity morphological changes, inhibition of cell proliferation in a time and dose dependent manner. Oral cancer is one of the leading causes of cancer worldwide. Many chemotherapeutics from plants have been tested in cancer, such as Mosinone-A, isolated from the bark of Annona squamous, acetogenin. further we analyzed anticancer activity by MTT assay, the generation of reactive oxygen species (ROS), the level of mitochondrial membrane potential and apoptotic morphological changes were analyzed by AO/EtBr. The results of an MTT assay demonstrated that Mosinone-A inhibited the growth of HEp2 cells in a dose-dependent manner. In addition, the induction of apoptosis was detected, as determined by morphological observation. These results indicated that Mosinone-A may induce apoptosis of HEp2 cells through the mitochondrial pathway.
Prevention of Cervical Cancer Among Women Aged 25-40 Years in Gujarat
Authors: Siva Subramanian N. , Patel Diya R. , Mahalakshmi B. , Ganvanthbhai Rohit Divya , Gopal R.
Published: February 2023

Cervical cancer cells develop in the area of the uterus that attaches to the vagina or the cervix. Various strains of the human papillomavirus, a sexually transmitted disease, are the primary cause of most cervical cancers (HPV). Therefore, the goal of this study was to protect women between the ages of 25 and 40 from developing cervical cancer. Therefore, this study aimed to prevent cervical cancer in women between the ages of 25 and 40. The aim and objectives of the study is to assess the knowledge regarding the prevention of cervical cancer among women and to assess the significance of the association relationship between post-test knowledge scores." The research design selected for the study was pre-experimental one group pre-test post-test research design". Non-probability convenience sampling technique was used to obtain 60 samples at selected are of Visnagar. Pretest done by structured knowledge questionnaire, after pre-test sensitization programme given to women. The Ost test is done using the same questionnaire. The data analysis showed that the mean value of the pre-test and post-test was 7.41 and 23.2, respectively, and the pre-test and post-test standard deviation of the value were 3.97. 4.89). The average disparity was (15.79). The estimated "t" value (25.58) was higher than the table value (1.67). This demonstrated that the knowledge levels of women were significantly different between the pre and post-test. Therefore, it is obvious that the sensitization campaign had a beneficial effect on women's knowledge levels. Thus, it was clear that sensitizing programmes had a positive impact on women's knowledge levels.
Fracture of The Sustentaculum Tali: Features and Surgical Management for Fracture Reduction
Authors: Mahapatra Pratik , Chegu Madhukar
Published: February 2023

Sustentaculum tali is a horizontal shelf-like projection on the medial part of the calcaneum. The medial facet articulates to the talus and supports the medial column of the foot. The spring ligament originates at the plantar aspect of sustentaculum tali, and flexor hallucis longus passes below it and indirectly supports the longitudinal arch of the foot. Sustentaculum tali is a strong cortical bone, so its isolated fracture is unusual. Therefore, the fracture of the sustentaculum tali is easily misdiagnosed. The patients complain of pain below the medial malleolus and also on passive movement of the flexor hallucis longus tendon. The patient has a history of falls from height with the foot supinated or associated talus fracture. Sustentaculum tali fractures are sometimes considered to be extra-articular fractures. CT scan helps diagnose the intraarticular medial facet involvement in this fracture and is now regarded as intra-articular. Need of the study is to make the clinicians aware that these fractures, even if rare, do happen, if mismanaged, may lead to complications like impingement of flexor hallucis longus, post-traumatic arthritis etc. The study aimed to identify the clinical features and diagnosis of sustentaculum tali fracture and its management to prevent complications. Surgical reconstruction of the sustentaculum tali with a direct medial approach and fixation with cannulated cancellous screws. Ten patients were operated on in the last five years, and seven patients showed up for follow-up and had excellent results per the AOFAS scoring system. All of the fractures had signs of radiological union by the end of the third month. In Conclusion, Sustentaculum tali fracture, when suspected, should not be ignored, and the fracture must be fixed surgically. The current aspect of surgical fixation is befitting and should not be disregarded.
Multimodal Exercises on Physical, Functional, Agility, and Perturbation for Post- ACL Reconstruction Among Athlete
Authors: Kaiyaperumal Anand Babu , Subbiah Babu , Manikavelu Paulraj
Published: February 2023

The anterior cruciate ligament (ACL) is one of the key ligaments that help stabilize our knee. Anterior cruciate ligament reconstruction (ACLR) is one of the most commonly performed orthopaedic surgeries to restore joint stability. Professional athletes may aim to return to play within 6 to 9 months safely. The multimodal approach is a condition that helps prevent injury recurrence. The study aims to determine the multimodal approach for ACL rehabilitation after reconstruction and the effect on physical, functional, agility, and perturbation for sports persons. The experimental study included 30 subjects randomly allocated into two groups group A(n=15) received multimodal training exercises, and group B(n=15) received standardized ACLR protocol training exercises. The outcome measure was International Knee Documentation Committee, Berg Balance Scale, Single Hop Test, and Agility-t-Test. Statistical analysis was done using both paired and unpaired "t" tests, which showed more significant improvement in group A. This study result shows that the Multimodal exercises along with standardized ACL rehabilitation protocol Group A show effective in improving the physical, functional, agility, and perturbation activities than the standardized ACLR protocol exercise alone Group B for sports persons who underwent ACL reconstruction after four weeks of interventions.
Physico-Chemical and Qualitative, Quantitative Chemical Compounds Analysis of Pleurotus florida in Thanjavur, Tamilnadu, India.
Authors: Ganesan Gayathri , Selvam Gomathi , Varatharasu Ambikapathy , Annamalai Panneerselvam
Published: February 2023

An extensive range of lignocellulosic waste is used in mushroom growing, which is recognized as a very successful way to recycle agricultural waste and make food. Primary and secondary metabolites analysis is fundamental for further pharmaceutical studies. In this present study, physico-chemical analysis viz., moisture content, ash value, crude fat, crude fibre content, carbohydrates and protein content were evaluated in Pleurotus florida. Phytochemical analysis of inPleurotusflorida was done using four different solvents like hexane, chloroform, methanol and aqueous, using a standard protocol. The result of the present study showed moisture content (7.22±0.03mg/g), ash value (3.20±0.00 mg/g), crude fat (4.50±0.00 mg/g), crude fibre content (2.81±0.08 mg/g), carbohydrates (0.18±0.06 mg/g) and protein (0.36±0.11 mg/g). Qualitative analysis of P. florida showed the presence of alkaloids, anthraquinone, flavonoid, glycosides, phenol, saponin, steroid, tannin and terpenoid. The above compound is further estimated quantitatively. Aqueous extract of P.florida showed alkaloid (0.42±0.02 mg/g), anthraquinone (0.65±0.00 mg/g), flavonoid (9.19±0.00 mg/g), glycosides (3.40±0.04 mg/g), phenol (4.74±0.00 mg/g), saponin (12.1±0.03 mg/g), tannin (26.1±0.00 mg/g) and terpenoid (0.73±0.01 mg/g). Methanolic extract showed alkaloid (2.91±7.85 mg/g), anthraquinone (3.48±0.06 mg/g), steroid (2.34±0.01 mg/g), tannin (21.5±0.00 mg/g) and terpenoid (0.45±0.03 mg/g). The other compounds like alkaloid (0.78±0.00 mg/g), anthraquinone (1.79±0.01 mg/g), flavonoid (10.9±0.04 mg/g), glycosides (12.8±0.05 mg/g), phenol (39.3±0.00 mg/g), saponin (35.8±0.00 mg/g), steroid (3.47±0.00 mg/g) and terpenoid (0.34±0.02 mg/g) were showed in chloroform extract of P.florida. In hexane extract, an alkaloid (0.59±0.03 mg/g), saponin (2.58±0.00 mg/g), tannin (426±0.00 mg/g) and terpenoid (0.38±0.01 mg/g) were estimated. Finally, the secondary metabolites were employed as an ontology tool (Protégé), and the outcomes were displayed in diagrammatic form. Protégé tool is one alternative technology for using smart art diagrams like bar and pie diagrams in future quantitative analysis response compounds for further immune system development studies.
Effect of Endurance and Breathing Training Versus Circuit and Breathing Training On Blood Pressure in Prehypertensive Overweight Adults
Authors: Saraswathi K. , Nandhagopal Koushik Kumar , Rajalakshmi G. , Thirulogachandar G. , Muthulakshmi K. , Revathi P. , Aishwarya B.
Published: February 2023

Hypertension is one among the leading risk factor for mortality and it is called as “the silent killer”. The new creation of the term ‘prehypertension’ classification by the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC 7 guidelines has provided a new path to the researchers to examine this group separately as it decreases the average life expectancy by as much as five years. Physical activity in the form of regular aerobic exercise has been proven in prevention of high blood pressure as well as the lowering of blood pressure among all levels of hypertension. The circuit training and endurance training exercises are known to reduces both systolic and diastolic arterial blood pressure along with improvement of health related quality of life. Breathing training exercises is the only simple method to improve respiratory control to reduce the blood pressure in prehypertensive individuals. The aim of this study is to examine the effects of endurance and breathing training versus circuit and breathing training on blood pressure, body mass index, waist circumference and quality of life in pre hypertensive overweight adults. This is an experimental design with pre and post comparative study. The subjects of 25-40 years of overweight both male and female, clinically diagnosed with prehypertension were included in the study. Those with known cardiac, pulmonary, neurological and musculoskeletal disorders were excluded in the study.40 subjects were randomly assigned into two groups, Group A received endurance training with breathing exercise while Group B received circuit training and breathing exercise for 12 weeks and 5 sessions per week. The outcome measures were blood pressure, BMI, waist circumference and quality of life. The outcome tools were sphygmomanometer, weighing machine, Stadiometer, inch tape and SF 36 Short-Form 36 Questionnaire. On comparing Pre-test and Post-test within Group A and Group B on blood pressure, body mass index, waist circumference and quality of life shows a significant difference in mean values at P<0.001. Thus this study concludes that 12 weeks of circuit training and breathing exercise reduces blood pressure, body mass index, waist circumference and improves the quality of life in pre hypertensive overweight adults.
Ganoderma Lucidum - A Potential Medicinal Mushroom Against MDR Isolates from The Secondary Infections of Covid-19
Authors: Pushpa T. , Senthilkumar G. , Ambikapathy V. , Kanmani A. , Prakash P. , Panneerselvam A.
Published: February 2023

The severe acute respiratory syndrome produced by COVID-19 is a highly infectious and pathogenic viral infection. Many COVID-19 patients have secondary bacterial infections, which enhance disease and increase death, particularly when requiring invasive mechanical ventilation. One of the most important medicinal mushrooms, Ganoderma lucidum, has been used for food, feed, and medication since the dawn of humanity. The present investigation aims to discover the potential of the medicinal mushroom Ganoderma lucidum inhibited multidrug-resistant isolates from secondary infection of Covid-19 patients. Isolation and identification of urine samples from secondary infection of post-Covid-19 patients and evaluate the antibiotic sensitivity assay, as identification of bioactive compounds, anti-inflammatory and antioxidant activity from Ganoderma lucidum. Totally 6 clinical urine samples were collected from the age group 45 to 60; 3 were male, and 3 were female. In total, nine bacteria and 10 fungi were isolated and identified. As antibiotic sensitivity assays of ceftriaxone, fluoroquinolones, azithromycin and amphotericin, nystatin and fluconazole were performed by the disc diffusion method against bacteria and fungi, the zone of inhibition was maximal in Klebsiella pneumoniae and Fusarium oxysporum. The aqueous and ethanolic extracts of Ganoderma lucidum were analyzed for the bioactive compounds, viz., steroids, flavonoids, alkaloids and phenolic compounds. The effect of the anti-inflammatory activity of the aqueous extract was excellent. The activity of the DPPH assay was maximum in aqueous and ethanolic extracts of all concentrations (100 to 500 ml). Antibiotic resistance could probably rise due to the frequent prescription of broad-spectrum empiric antimicrobials to COVID-19 patients. Hence, Ganoderma lucidum can be exploited to prevent secondary infection in COVID-19 patients.
Design and Implementation of a Track n trace 2D Multi Scanner Bulk Code Reader for Pharmaceutical Packaging
Authors: Kasagani Vidyasagar , Kakollu Vanitha
Published: February 2023

With various compliance initiatives surrounding the traceability of medical drugs coming into prominence and with federal regulations becoming more stringent, there is a need to efficiently manage the supply chain process involving drug packaging. To enable traceability of the drugs being packaged, many manufacturers are implementing barcoding of product labels which contains a minimum of the attributes namely GTIN, lot number, serial numbers, expiry date, manufacturing dates, etc., to enable traceability of the packaged item. Currently, manufacturers are looking for ways to keep their supply chain moving at an efficient and optimal process. One of the challenges was to build automated equipment providing a well-defined and properly structured framework for functioning, designing, and implementing of Track N Trace Counterfeit Risk Management (CRM) application to increase the speed of the aggregation with the child-to-parent aggregation and generation of online case labels after the required child's Quantity in Multi carton aggregation station. Track N Trace Counterfeit Risk Management (CRM) allows the manufacturers to establish the parent-child relationship during packaging their drugs. Also, various guidelines US Drug Supply Chain Security Act (DSCSA), EU regulation (Falsified Medicines Directive-FMD), Brazilian Health Regulatory Agency (ANVISA), Indonesia's National Agency of Drug and Food Control (NADFC), India’s Directorate General of Foreign Trade - DGFT, and Australia TGA will need to be integrated into one single source of equipment that can meet with their barcoding regulation for tracking of drugs packed. Machine Vision systems are finding themselves in use in the pharma machinery and the "multi-carton" equipment that has been built for implementation for pharmaceutical packaging uses the vision systems architecture. We aimed to build a counterfeit risk management software solution that ensures compliance with various regulatory agencies by building a common framework that can be extensible for any further changes to the guidelines and/or additional regulatory guidelines from other countries. Lots of design architecture work has been refined through continuous process improvement practices and we developed a software tool that improves efficiency and requires minimal changes to the current manufacturing/packaging supply chain lines.
Assessment of Knowledge and Risk Factors of Osteoporosis Among the Adult and Elderly
Authors: Veerendra Uppara , Deepthi Reddy L. , Mathews Medha Elizebeth , Vyshnavi G.
Published: February 2023

A bone-healthy lifestyle is essential for everyone, like babies, children, teenagers, and young adults, and is particularly important for patients with osteoporosis, the most common skeletal disorder characterized by low bone mass and structural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Low bone mass and skeletal fragility in adults may be due to low peak bone mass in early adulthood, excessive bone loss in later life, or both. Even though osteoporosis is a preventable disease, its high prevalence has resulted in massive morbidity, mortality, and decreased quality of life due to a lack of disease knowledge and awareness among the general public. Evidence based on other disorders shows that learning about the disease can help in early recognition and information about risk factors leads to prevention through lifestyle and behaviour modifications. A six-month cross-sectional study was performed with the objective of assessing the knowledge of osteoporosis, identifying the risk factors and exploring the association between sociodemographic factors and knowledge levels of osteoporosis among adults and the elderly by using the Revised Osteoporosis Knowledge Test. Participants were categorized into different socioeconomic classes by using the Kuppuswamy scale. In our study, from a total of 553 participants' responses, 217 (39.24%) were men, and 336 (60.75%) were women, with no significant variation in mean age distribution. Most participants belong to the upper-middle-class category, with a comparatively high percentage of women, followed by the lower-middle-class sort. The knowledge and understanding of osteoporosis and its contributory risk factors are poor among current study participants, which stresses the need to improve understanding among men and women through awareness programs, mainly targeting the low socioeconomic category populations.
Dentinogenesis Imperfecta Associated with Hypophosphatemic Rickets- A Report of the Rarest Case
Authors: Sathawane Dr. Ramhari , Lanjekar Dr. Ashish , Madne Dr. Isha , Deshmukh Dr. Pranada , Akhtar Dr. Zareesh , Tayade Dr. Charwak , Deotale Dr. Komal , Jaiswal Dr. Raksha
Published: February 2023

Rickets is a childhood bone disorder. It is caused due to deficiency of Vitamin D, calcium, and phosphate. Bones become soft and weak and are prone to fracture due to inadequate intake of these nutrients. Rickets result from abnormalities of the growth plate cartilage predominantly affecting longer bones and leading to poor bone growth, defective mineralization, and bony deformities such as bow legs and knock-knees. This case report presents a rare case of a 21-year-old female patient with discoloration and abnormalities of teeth since childhood with hypophosphatemic rickets in early childhood who suffered from subsequent loss of tooth structure and bone deformities. Orthopantomogram revealed bulbous crowns of teeth with cervical constriction, obliterated pulp chambers, and slender roots. X-ray chest revealed decreased costochondral angle suggestive of pigeon chest. Serum calcium and Vitamin D were, but serum phosphorus levels were decreased. The patient was examined by a Physician & Orthopedic Surgeon. On the basis of clinical-radiographic features and serum biochemistry findings, this case was diagnosed as Dentinogenesis Imperfecta associated with Hypophosphatemic Rickets.
Dectin-3-targeted antifungal liposomes efficiently bind and kill diverse fungal pathogens
Authors: Meagher Richard B. , Choudhury Quanita J. , Ambati Suresh , Link Collin D. , Lin Xiaorong , Lewis Zachary
Published: February 2023

DectiSomes are anti-infective drug-loaded liposomes targeted to
pathogenic cells by pathogen receptors including the Dectins. We have
previously used C-type lectin (CTL) pathogen receptors Dectin-1,
Dectin-2, and DC-SIGN to target DectiSomes to the extracellular
oligoglycans surrounding diverse pathogenic fungi and kill them.
Dectin-3 (a.k.a. MCL, CLEC4D) is a CTL pathogen receptor whose
known cognate ligands are partly distinct from other CTLs. We expressed
and purified a truncated Dectin-3 polypeptide (DEC3) comprised of its
carbohydrate recognition domain and stalk region. We prepared
amphotericin B (AmB)-loaded pegylated liposomes (AmB-LLs) and coated
them with this isoform of Dectin-3 (DEC3-AmB-LLs), and we prepared
control liposomes coated with Bovine Serum Albumin (BSA-AmB-LLs).
DEC3-AmB-LLs bound to the exopolysaccharide matrices of Candida
albicans, Rhizopus delemar (f.k.a. R. oryzae), and
Cryptococcus neoformans from one to several orders of magnitude
more strongly than untargeted AmB-LLs or BSA-AmB-LLs. The data from our
quantitative fluorescent binding assays were standardized using a
CellProfiler program, AreaPipe, that was developed for this purpose.
Consistent with enhanced binding, DEC3-AmB-LLs inhibited and/or killed
C. albicans and R. delemar more efficiently than control
liposomes, which significantly reduced the effective dose of AmB. In
conclusion, Dectin-3 targeting has the potential to advance our goal of
building pan-antifungal DectiSomes.
COVID-19 Induced Pheochromocytoma Multisystem Crisis
Authors: Hansen Caleb , Crosby James , Findlay Jason , Perez Jorge
Published: February 2023

A 43 year old male presented to a community hospital emergency
department for evaluation of sudden onset shortness of breath,
tachycardia, and hypertension. Initial evaluation showed an adrenal mass
on chest computed tomography. There was biochemical evidence of multi
organ damage. Patient had elevated plasma metanephrine and
normametanephrine levels.
Sclerosing Encapsulating Peritonitis: A mysterious cause of small bowel obstruction
Authors: Fullana Jose Ortiz , Mantilla Christian , Bellido Omar Rovira , Rodriguez Javier Ruiz , Bernardini Hiram Soler
Published: February 2023

Sclerosing Encapsulating Peritonitis (SEP), also known as Abdominal
Cocoon Syndrome, is a rare condition characterized by nonspecific
episodes of bowel obstruction and intestinal dysfunction. This is a case
of a 45-year-old male with multiple previous episodes of abdominal pain
and obstruction.
Granular parakeratosis involving the dorsum of hands; Skin reactions due to irritant agents: A case report
Authors: Nia Mohammad Shariat , azhari Vahideh sadat , Shakoei Safoura
Published: February 2023

Granular parakeratosis is an acquired keratinization disease. We
describe the unusual presentation of granular parakeratosis. A
27-year-old healthy female presented with multiple erythematous and
brown discoloration plaques on the dorsal aspect of her hands for eight
months. Repeated washing, using detergents, and maceration of the skin
could develop her lesion.
A Quasi-optical resonator with new coupling method and parasitic-mode-suppressing in 110 ~ 170GHz
Authors: Cheng Jin , Zhang Yunpeng , Long Jiawei , Li En
Published: February 2023

In this paper, a quasi-optical resonator with new coupling method and
parasitic-mode-suppressing in 110~170GHz is proposed.
The coupling of THz quasi-optical resonator in this paper is realized by
PCB substrate processing and pressurized flange. At the same time, the
parasitic mode is effectively suppressed by slitting the plane mirror to
reduce the influence on the main mode during the test. And fused quartz
sample was tested to verify the feasibility of the system for complex
dielectric testing of materials in 110~170GHz.
EXPERIMENTAL MANIPULATION OF NEST TEMPERATURE AND RELATIVE HUMIDITY REDUCES ECTOPARASITES AND AFFECTS BODY CONDITION OF BLUE TITS (Cyanistes caeruleus).
Authors: Río Marina García del , Cantarero Alejandro , Castaño-Vázquez Francisco , Merino Yago , García-Velasco Javier , Merino Santiago
Published: February 2023

Studies exploring the effect of microclimatic changes on host-parasite
relationships are scarce, however, many models predict changes in the
distribution and incidence of diseases associated with climate change.
In this study, we increased both temperature and relative humidity in
blue tit nest-boxes during the breeding season, trying to discern
between the effect of both variables on the abundance of ectoparasites
reported in previous studies and, also, on the body condition of the
nestlings and adults. Temperature and relative humidity were
experimentally increased an average of about 2ºC and 15 units
respectively. The abundance of blowfly Protocalliphora azurea pupae was
significantly reduced in nests with increased temperature as compared to
control nests and nests with increased relative humidity, and was also
significantly reduced in nests with increased relative humidity as
compared to control nests. The abundance of Dermanyssus spp. mites and
Ceratophyllus gallinae flea larvae was significantly reduced in nests
with increased relative humidity. However, there was no significant
effect of the experiment on flying insect vectors abundance (Blackflies
and biting midges.). On the other hand, body condition and mass of
nestlings were lower in nests with increased relative humidity and
nestlings’ mass was also lower in heated nests. However, the body
condition and mass of the adults was not significantly affected by the
experiment. In addition, blowfly Protocalliphora azurea pupae and biting
midges Culicoides spp. had a significant negative effect on body
condition and mass of nestlings and adults. In conclusion, an increase
in temperature, on the one hand, and relative humidity, on the other,
reduces the abundance of ectoparasites, which suggests that these
parasites are sensitive to sudden changes in the microclimate in which
they develop. In addition, these fluctuations negatively affect the body
condition and mass of blue tit nestlings despite the concurrent decrease
of parasites in nests.
Mycobacterium Tuberculosis Protein PE17 Induces Organelle Disruptions Upon Heterologous Expression in A549 Human Airway Epithelial Cells
Authors: Starai Vincent , Loy Allyson T. , Shaffer Lucinda N. , Gavalas Sophia T. , Mermilliod Anna A. , Quinn Frederick , Wolstenholme Adrian J. , Reaves Barbara J.
Published: February 2023

Mycobacterium tuberculosis (Mtb) is the causative agent of
tuberculosis. Its success as a pathogen is dependent on an arsenal of
secreted virulence factors which target host cell organelles. In this
report, we have characterized the effects of two proteins known to be
secreted by Mtb on eukaryotic mitochondria: ESAT-6 and a member of the
poorly-described PE/PPE protein family, PE17. Intracellular expression
of ESAT-6 in A549 cells did not induce mitochondrial fragmentation. In
contrast, expression of PE17 caused extensive mitochondrial
fragmentation and an overall reduction in mass. Further characterization
of the effects of PE17 within host cells revealed a dramatic decrease in
the mass of the trans-Golgi network and the Golgi stack with lesser but
significant decreases in late endosomes and lysosomes. The endoplasmic
reticulum and organelles of the early endocytic pathway were not
significantly affected. PE17 specifically colocalized with large,
cytoplasmic lipid droplets via a C-terminal domain, suggesting a
significant role for PE17 in the disruption of multiple host cell
organelles and a novel interaction with host lipid droplets.
Gut microbiomes of mammal species show differential responses to identical series of environmental stressors
Authors: Koziol Adam , Odriozola Iñaki , Leonard Aoife , Eisenhofer Raphael , José Carlos San , Aizpurua Ostaizka , Alberdi Antton
Published: February 2023

The gut microbiomes that associate with animals can represent labile
units of cooperating and competing microbes. This lability, sometimes
referred to as metagenomic plasticity, has been posited to have an
important role as an additional axis of hosts’ phenotypic plasticity.
However, whether and how metagenomic plasticity varies across hosts with
different ecological and evolutionary features remains unclear. To
address this, we utilised faecal-derived genome-resolved metagenomics
and compared how the taxonomic, phylogenetic and functional microbial
dynamics varied across a series of disturbances in two mammal species;
namely, the insectivorous-specialist, Crocidura russula (N = 29) and the
omnivorous-generalist Apodemus sylvaticus (N = 22). Although faecal
microbial diversity of both species remained stable, compositional
dynamics differed significantly. C. russula exhibited substantially
higher variability and directionality of microbial responses, with
higher predictability associated with each disturbance, compared to A.
sylvaticus. Predictions of functional traits using joint-species
distribution modelling supported these observations. C. russula showed
strong functional response to perturbations, with marked directional
variation of various metabolic functions. In contrast, the significantly
higher functional diversity and redundancy of the A. sylvaticus
microbiome likely buffered its functional response to perturbations,
which remained more constant across time. Our results indicate that the
intrinsic properties (e.g., diversity, redundancy) of gut microbiomes
associated with animals with different biological attributes shape the
taxonomic, phylogenetic, and functional response to environmental
stressors. This level of plasticity might affect the capacity of animal
hosts to acclimate and adapt to changing environments.
Quantitative Super-resolution of Synaptic Proteins
Authors: Zanacchi Francesca Cella
Published: February 2023

Single molecule localization microscopy (SMLM) recently became more and more popular for studying the synaptic architecture, providing substantial advances in modern neuroscience. Recently developed methods based on DNA origami calibration transformed SML into an effective quantitative tool able to estimate the oligomeric states of macromolecular complexes. In this work, we apply a recently developed quantitative method based on stochastic optical reconstruction microscopy (qSTORM) to study the distribution of the synaptic proteins Homer in hippocampal neurons. Our experiments prove qSTORM as a suitable tool for novel quantitative insights into the nanoscale organization of excitatory synapses.
Deep Learning for the Classification of Autism Using Functional Neuroimaging
Authors: Ryali Srikanth
Published: February 2023

Deep learning models have advanced many branches of science. However, these models have not been adequately developed for neuroimaging applications mainly because of the non-availability of large labelled datasets. In this study, we present an explainable deep learning approach to investigate the neurobiology of the autism spectrum disorder (ASD), which is one of the most prevalent neurodevelopmental disorders. Our approach achieved state of the art classification accuracy and identified brain features in discriminating ASDs from the typical subjects and finally identified features that predicted the severity of the symptoms.
Machine Learning-based Diagnosis of Autism Spectrum Disorder Using Brain Imaging
Authors: Venkatasubramanian Ganesan
Published: February 2023

In spite of research over the past decades, robust, replicable, and clinically translatable markers to objectively diagnose psychiatric disorders are yet to be ascertained. Several factors such as biological heterogeneity (partly due to the complex genetic basis that is further compounded by environmental interactions), the potential mismatch between contemporary diagnostic criteria / clinical symptom scores and findings that emanate from cutting-edge neuroscience observations, and similar others have made the identification of biomarkers a daunting challenge. This challenge becomes much harder to solve in the context of disorders of childhood onset such as, autism spectrum disorders (ASD) especially because of the additional complexity of examining the developing brain.
Pea seeds and alfalfa hay pellets: to increase the economic return of poultry farms
Authors:   Latvia University of Life Sciences and Technologies, Cerina Sallija , Proskina Liga ,   Latvia University of Life Sciences and Technologies
Published: February 2023

The output of poultry products by poultry enterprises in the world was mainly determined by feeding techniques and poultry productivity. The productivity of poultry is characterised by the rate of egg-laying or the number of eggs produced per hen a year and affected by the availability and diversity of feed materials (especially protein). In recent years, researchers have focused on legumes of various species as promising sources of protein for livestock production, such as beans, peas, lupine, alfalfa etc.; therefore, in Latvia more attention is paid to the production of protein crops or legumes. The aim of the research was to identify the impact of domestically sourced legume seeds included in diets for laying hens on the economic performance of egg production. Two kinds of protein crops were examined by the research: peas `Bruno` and dried alfalfa pellets. Feeding laying hens with peas or dried alfalfa pellets made it possible to produce eggs with a heavier weight (55.28-67.07%), which in turn makes it possible to increase revenues (10.3-12.9%) from the sales of eggs with the same feed consumption.
Productivity development and regional specificities of economies of scale of specialised farms in Central and Eastern European (EU 10) agriculture (2005-2016)
Authors:   Corvinus University of Budapest, Forgacs Csaba
Published: February 2023

The paper explores which farm types by specialisation direction2 (ten different types) and at what farm sizes by physical size3 (five categories) of specialised farms backed more production growth and productivity development in Central and Eastern European Countries (CEECs, EU104) over the period of 2005-2016. We compare EU10 average figures to EU27/15 averages and outline the changes by specialisation in total resource use of (i) labour (AWU), (ii) land (UAA) as well as in (iii) average farm size (UAA/specialised farms), (iv) total farm productivity (SO/farm), (v) labour productivity (SO/AWU) and (vi) area productivity (SO/UAA). We conclude that production and productivity growth of specialised farms in EU 10 differs by country, and by type and size of farming and, each CEEC has followed her own path of farm structure development in line with the country’s tradition and economic possibilities. We give regional characteristics of development in main specialisation types broken down to 5 farm size categories. We concluded the number of cereal farms increased in 6 out of 10 countries in all farm size categories and that of cattle farms went up in 5 out of EU 10 from 2005 to 2016. Farms with these two specializations have significantly extended agriculture land use and more than tripled production, but used more labor compared to basis year. SO/Farm/UAA/AWU productivity indicators of cereal farms increased quite a bit in most farm size categories in all EU 10 countries to a less extent in cattle, poultry pig and dairy farms. Growth in area productivity was led by pig, poultry, and cereal farms at E 10 level. Growth of the three productivity indicators in EU 10 are scattered quite a bit by farm types, and by countries but generally was headed by three farm size categories as 5-19.9 ha, 20-49.9 ha and 50-99.9 ha. However, the distance between EU10 and EU15 related to the level of production, land, and labour productivity still shows wide gap which needs to further narrow in the coming years.
Dynamic strategic marketing adjustment of the vegetable producers sector under Covid crisis conditions
Authors:   Krizevci College of Agriculture, Jercinovic Silvije
Published: February 2023

The paper deals with the issue of the pandemic and its impact on the work of vegetable producers in the Republic of Croatia in the domain of their marketing activities. Namely, the changed business circumstances because of changing daily life and consumption patterns, forced entrepreneurs, including vegetable producers, to revise existing businesses and marketing strategies in terms of adjustment and in that way to take new measures and activities related to distribution and sales channels. The purpose of this paper is to gain insight into the most effective ways to promote and sell vegetables in times of changing business conditions in the domestic vegetable market under pandemic conditions. The aim of this paper is to investigate the impact of individual applied marketing adjustments of small agricultural enterprises in the sector of vegetable production in crisis conditions on their business success and satisfaction of their owners. The main primary research was conducted using the survey method on a sample of vegetable producers in the Republic of Croatia. For analysis and processing of collected data, descriptive analysis of measures of central tendency, measures of dispersion, measures of asymmetry and roundness, then bivariate analyses, and multivariate methods were used. SPS 21 software package was used for data processing.
Customer portfolio planning in third party logistics using system dynamic approach
Authors:   Riga Technical university, Kotlars Aleksandrs , Jurgelane-Kaldava Inguna ,   Riga Technical university, Skribans Valerijs ,   Riga Technical university
Published: February 2023

According to resource-based view, market orientation can help companies to enhance performance. By looking at customer portfolios of global 3PL companies, certain customer sector specialization can be noticed, hence, market orientation is an asset that is valuable and provides a competitive advantage to companies that possess it. A detailed in-depth look into internal processes of 3PL companies is needed to demonstrate interrelationships between 3PL key resources, which are information, knowledge, relational and human resources. The purpose of this study is to develop a model that would demonstrate transmissions between commercial and operational processes in 3PL companies. A system dynamic approach is chosen to demonstrate these interrelations. This study is organized as follows. First, an empirical literature research is done to discover studies related to resources of 3PL companies. Second, a model demonstrating commercial and operational processes of 3PL companies is developed, based on system dynamics approach. Third, approbation of the model is done to test multiple scenarios of 3PL portfolio planning. As the result of the study, there are suggestions developed for 3PL companies’ management teams addressed to improve portfolio planning process within 3PL organizations.