bluuebunny/crossref_metadata_2025 huggingface dataset:
RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation
Authors: Ferreira Daniel B , Gasparoni Leticia M , Bronzeri Cristiane F , Paiva Katiucia B S
Published: June 2024

BACKGROUND

Validation of the reference gene (RG) stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction (RT-qPCR) data normalisation. Commonly, in an unreliable way, several studies use genes involved in essential cellular functions [glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 18S rRNA, and β-actin] without paying attention to whether they are suitable for such experimental conditions or the reason for choosing such genes. Furthermore, such studies use only one gene when Minimum Information for Publication of Quantitative Real-Time PCR Experiments guidelines recommend two or more genes. It impacts the credibility of these studies and causes distortions in the gene expression findings. For tissue engineering, the accuracy of gene expression drives the best experimental or therapeutical approaches.

AIM

To verify the most stable RG during osteogenic differentiation of human dental pulp stem cells (DPSCs) by RT-qPCR.

METHODS

We cultivated DPSCs under two conditions: Undifferentiated and osteogenic differentiation, both for 35 d. We evaluated the gene expression of 10 candidates for RGs [ribosomal protein, large, P0 (RPLP0 ), TATA-binding protein (TBP ), GAPDH , actin beta (ACTB ), tubulin (TUB ), aminolevulinic acid synthase 1 (ALAS1 ), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (YWHAZ ), eukaryotic translational elongation factor 1 alpha (EF1a ), succinate dehydrogenase complex, subunit A, flavoprotein (SDHA ), and beta-2-microglobulin (B2M )] every 7 d (1, 7, 14, 21, 28, and 35 d) by RT-qPCR. The data were analysed by the four main algorithms, ΔCt method, geNorm, NormFinder, and BestKeeper and ranked by the RefFinder method. We subdivided the samples into eight subgroups.

RESULTS

All of the data sets from clonogenic and osteogenic samples were analysed using the RefFinder algorithm. The final ranking showed RPLP0/TBP as the two most stable RGs and TUB/B2M as the two least stable RGs. Either the ΔCt method or NormFinder analysis showed TBP/RPLP0 as the two most stable genes. However, geNorm analysis showed RPLP0/EF1α in the first place. These algorithms’ two least stable RGs were B2M/GAPDH. For BestKeeper, ALAS1 was ranked as the most stable RG, and SDHA as the least stable RG. The pair RPLP0/TBP was detected in most subgroups as the most stable RGs, following the RefFinfer ranking.

CONCLUSION

For the first time, we show that RPLP0/TBP are the most stable RGs, whereas TUB/B2M are unstable RGs for long-term osteogenic differentiation of human DPSCs in traditional monolayers.
Effect Modification of Heat-Related Mortality Risk by Air Pollutants in Shandong, China
Authors: Zhao Zhonghui , Chu Jie , Ren Jie , Xu Chunxiao , Xu Xiaohui , Cao Yanwen , Schikowski Tamara , Zhao Qi , Liu Qiyong , Chen Gongbo , Lu Zilong , Guo Xiaolei , Ma Wei , Wang Haitao , Ma Jixiang
Published: June 2024

Although studies have reported the modification effect of air pollutants on heat-related health risk, little is known on the modification effect among various particulate matter with different particle size on mortality. We aimed to investigate whether the associations of hot temperatures with daily mortality were modified by different air pollutant levels in Shandong Province, China. Daily data of air pollutants, meteorological factors, and mortality of 1,822 subdistricts in Shandong province from 2013 to 2018 were collected. We used a time-stratified case-crossover model with an interaction term between the cross-basis term for ambient temperature and the linear function of particulate matter ≤1 µm (PM1), PM2.5, nitrogen dioxide (NO2), and ozone to obtain heat-mortality associations during the hot season. Results showed that the cumulative odds ratio of extreme heat on mortality over 0 to 10 days was 3.66 (95% CI: 3.10–4.31). The mortality risk during hot seasons was stronger at high air pollutant levels. The modification effect of particulate matters on heat-related mortality decreased by its aerodynamic diameter. Females and older adults over 75 years were more vulnerable to the modification effect of air pollutants, and significant differences were detected in the association between temperatures and mortality stratified by PM1 and PM2.5. Higher heat-related mortality risks were observed at high NO2 levels, especially for cardiorespiratory disease. The findings suggest that more consideration should be given to the combined effect of very fine particles and NO2 with ambient heat when developing healthcare strategies, and women and older adults should be given priority in health-related settings.
Self-Rated Competence of Ugandan Healthcare Workers to Obtain Informed Consent for Autopsy
Authors: Bongomin Felix , Kibone Winnie , Nantale Ritah , Lukande Robert , Bromley Ruth , Muzoora Conrad , Hamer Davidson H.
Published: June 2024

We examined the self-rated competence of Ugandan healthcare workers (HCWs) in obtaining informed consent for autopsies, considering the challenges of low autopsy acceptance rates globally. In September and October 2023, we conducted a nationwide cross-sectional study of HCWs, who provided informed consent to participate and completed an online, self-administered questionnaire. Participants’ self-rated competence in obtaining informed consent for autopsy was assessed through Likert scale questions. Knowledge and practices were also assessed. All scores were converted to percentages, with scores ≥80% indicating higher competence. We enrolled 216 HCWs (including 145 [67.1%] doctors), with a mean age of 31.6 ± 7.2 years. Overall, 55.6% (n = 120) had ever assisted in obtaining consent for autopsy, 43.6% (n = 100) had ever obtained consent for autopsy themselves, and 13.4% (n = 29) had ever attended training on obtaining consent for autopsy. The mean competency score was 59.8 ± 17.0% (perfect score, 100%), with 29 (13.4%) participants demonstrating high competence. Healthcare workers with adequate knowledge had higher competence scores (odds ratio [OR]: 15.0, 95% CI: 6.17–36.58, P <0.001). Compared with nurses/midwives, doctors had 73% lower odds of having a high competence score (adjusted OR: 0.27, 95% CI: 0.08–0.94, P = 0.040). Fewer than one in five Ugandan HCWs demonstrated high self-rated competence or possessed adequate knowledge regarding informed consent for autopsies, and only a few had received specialized training on how to obtain consent for an autopsy. Therefore, there is a pressing need for enhanced training and increased awareness among Ugandan HCWs in obtaining informed consent for autopsies.
Isolation and Growth Kinetics of Bogoria Virus from Phlebotomine Sandflies Sampled in Baringo, Kenya
Authors: Thiiru Jane Wambui , Langat Solomon , Mulwa Francis , Cinkovich Stephanie , Koka Hellen , Yalwala Santos , Khamadi Samoel , Onguso Justus , Odemba Nicholas , Ngere Francis , Johnson Jaree , Egbo Timothy , Garges Eric , Ojwang Elly , Eyase Fredrick
Published: June 2024

Phleboviruses are an emerging threat to public health. Recent surveillance efforts in Kenya have unveiled novel phleboviruses. Despite these efforts, there remain knowledge gaps. This study tested female sandflies from diverse ecological settings in Kenya for arboviruses. Sandfly pools were cultured in Vero-CCL cells. Pools showing reproducible cytopathic effects were subjected to next-generation sequencing, followed by phylogenetic analysis. In vitro, cell kinetics analysis was performed using both Vero-E6 cells and C6/36 mosquito cells. One pool from Baringo, Kenya, tested positive for Bogoria virus (BOGV). The BOGV genome clustered in a single clade with previously obtained BOGV genomes. No significant differences were observed between Vero and C6/36 cell growth kinetics. This study has confirmed the presence of BOGV among sandflies in Baringo Kenya and demonstrated growth in mosquito cells.
Utopie: Postkoloniale Lektüren. Poetiken, Räume, Gemeinschaftsentwürfe
Authors: Stelzer Philipp , Brown Timothy , Riechers Hans-Christian , Gerstner Jan , Vijayakumaran Jana , Pohl Peter C. , Vilar Loreto , Yowa Serge , Esposito Gianluca
Published: June 2024

Seit Entstehung der Gattung Utopie im europäischen Expansionszeitalter werden ihre Schauplätze immer wieder in außereuropäische Räume ausgelagert. Dem hierin bereits angedeuteten Zusammenhang von Utopie, Eroberung und Kolonialphantasien gehen die literaturwissenschaftlichen Beiträge des vorliegenden Bandes nach. Der erste Teil widmet sich frühen Diskursformationen, die das Verhältnis von Utopie und Kolonialismus anhand von vormodernen und frühen modernen Werken (u.a. Epos, Idylle, Drama) analysieren. Der zweite Teil untersucht das Verhältnis ausgehend von Verabschiedungen, Rückblicken und Revisionen aus postkolonialer Perspektive und anhand von Texten des 20. und 21. Jahrhunderts. Nachgezeichnet werden auf diese Weise utopische Imaginationen (post-)kolonialer Räume und deren komplexes Verhältnis zur Konfiguration vorgestellter europäischer Gemeinschaften.
Challenges and Opportunities of Big Data Analytics for Maritime and Shipping Industry
Authors: Dr.B.V.Ramalingeswara Rao  , Amritha CS
Published: June 2024

Big Data is more than just large amounts of data. Big Data allows companies to use enormous amounts of data from non-traditional sources. A non-traditional source is time-sensitive data, not just past recorded data, used to optimize the industry and ports. Big Data includes texts, audios, videos, and real-time information. Big data is a big category which includes the data in both structured and unstructured forms stored in the cloud. For e-commerce, the supply chain data source might be order management systems, warehouses, payroll, inventory systems and carrier data. For the Maritime analytics market traditional data may come from dockyards, ships, vessel operations, bill of lading, traditional (fixed) data is used to analyze profits and losses. Nontraditional is time sensitive and not always quantifiable. Examples of nontraditional data are weather data, traffic and location data and movement of freight via transportation
Genetic Diversity in Acalypha indica L., (Copper leaf) through RAPD analysis
Authors: Dr. Shireesha Somineni  , Dr. Prashanthi Sandepogu
Published: June 2024

In the present study, Acalypha indica L., plants were treated with SA & JA alone T2 (1.0mM SA), T3 (3.0mM SA), T4 (2.0 μM JA), T5 (4.0 μM JA) and combination of hormones like T6 (1.0mMSA + 2.0μM JA), T7 (1.0mM SA+4.0μM JA), T8 (3.0mMSA+2.0μM JA) and T9
(3.0mM SA + 4.0μM JA), T1 (control). The treatment was conducted for 25, 40 and 55 days and results were observed. After 55 days, genetic diversity was investigated using RAPD primers. All the numerical and taxonomical analysis was conducted using the NTSYS-PC software version 2.0 and cluster analysis of the complete data is done. The population which showed high percentage of polymorphism was selected. The samples from this population were chosen for further photochemical analysis and the active principle has been quantified. The population which exhibited both high percentage of polymorphism and high amount of active principle was considered to be the superior genotype.
A Technical Review on Emotion Detection from Informal Text for Indian Regional Languages: Approaches and Challenges
Authors: Kajal Patil  , Jitendra Nasriwala  , Rakesh Savant
Published: June 2024

Effective communication is a crucial element in the existence of a human being. Emotions are a common component of human communication and can appear in a variety of ways, including spoken words, written messages, and non-verbal indicators like gestures and facial expressions. Textual communication which is the common way of interaction has been rapidly increasing day-by-day. People nowadays are using social media to convey their thoughts and beliefs in the form of comments, posts and stories with associated emotions. As a result, there is a growing need to detect and understand the emotions conveyed in texts. Although the emotions expressed in text are readily understood by the human brain, teaching a machine to do the same is a challenging task. However, when dealing with Indian languages, this process becomes especially difficult. As India has plenty of vernacular languages, people opt to use monolingual or code-mix languages. These types of languages are generally informal way which creates an obstacle to convey the emotions. The shortage of annotated corpus especially for regional languages is also one of the challenges. This paper aims to analyze and review emotion detection from textual data specifically for Indian regional languages and its challenges.
Integration Of Blockchain With Fog Computing To Improvise Security & Privacy Issues
Authors: Ms. Meenu  , Dr. Devender Kumar
Published: June 2024

The concept of fog computing was suggested to help cloud computing for the fast data processing of Internet of Things (IoT) based applications. Even, fog computing faces many challenges such as Security, Privacy & Storage. One way to handle these challenges is to integrate blockchain with fog computing. There are several applications of blockchain and fog computing integration that have been proposed, recently, due to their lucrative benefits such as enhancing security and privacy. Also we have to systematically review the literature on both the technologies (blockchain & fog computing). The purposes of integrating blockchain and fog computing is to tailored search criteria established from the research questions. In this research, the combination of blockchain and fog computing approach for several purposes such as security, privacy, access control, and trust management. By Insufficient laws and standard, it is difficult for blockchain and fog computing to be integrated in the future. Particularly in light of newly developed technologies like quantum computing and artificial intelligence has more power. In this paper we tried to minimize some security issues in fog computing via using the technology of blockchain.
Design of an efficient energy based dual level co-operative route protocols in multiple hop WSNs
Authors: Hanumanthappa S.N  , Dr. Girish V. Attimarad
Published: June 2024

The design and implementation of an energy efficient dual stage cooperative routing protocol (DSCR) in multiple hop wireless nets is discussed in this paper in brief, with the goal of improving network life-time, boosting dependability, and reducing energy consumption. This contribution’s major goal is to propose an enhanced version of the double stage data transfer system that computes the routing path utilizing cooperative mechanisms and the notion of reduced node energy. The work presented here also includes talks, discussion and graphical representations of the various outcomes achieved for all of the test scenarios, as well as the relevant observations and explanations. The research paper comes to a close with the multiple hop networks’ overall conclusions remarks.
Federal project “Professionalitet” — new opportunities for the development of an educational organization
Authors: Soimina T. V. , Svetlichnaya E. A.
Published: June 2024

The results of activities, prospects and opportunities for the development of educational and production centers (clusters) of railway transport during the implementation of the federal project “Professionalitet” are analyzed.

The purpose of the study is to assess the development opportunities of educational organizations participating in the implementation of the federal project “Professionalitet”, as well as to broadcast the experience of participation in the project of the Yaroslavl branch of PGUPS.
Water Carrying Capacity on Small Islands Tourism: Case Study of the Tidung Islands, Jakarta
Authors: Arijuddin Basyar Ihsan
Published: June 2024

This study examines the water carrying capacity of the Tidung Islands, a popular small island tourism destination in Jakarta, Indonesia. The research aims to measure the availability of water resources and assess the balance between water supply and demand, focusing on both domestic and tourism needs. Using a water balance approach, the study analyzes seasonal fluctuations in precipitation, evapotranspiration, runoff, and changes in water storage. The results indicate that while Tidung Islands currently have a surplus of water resources, projected increases in population and tourism will lead to periods of water deficit by 2040. The study highlights the critical need for sustainable water management practices, including rainwater harvesting, efficient water use, and community involvement in conservation efforts. Implementing these strategies is essential to ensure long-term water security and support the continued growth of tourism and local development in Tidung Islands.
Mortality rates for men and women from cerebrovascular and nervous diseases in the regions of Russia in 2013 and 2022
Authors: Kakorina E. P. , Samorodskaya I. V. , Kotov S. V.
Published: June 2024

In recent years, researchers have noted an increase in mortality from neurodegenerative diseases and a decrease in mortality from strokes. There have been no studies comparing mortality from these causes in the regions of the Russian Federation.

Aim:comparative analysis of regional (age-) standardized death rate (SDR) among men and women from cerebrovascular diseases (CVD) and nervous system diseases (NSD) in 2013 and 2022 and discussion of factors influencing SDR.

Materials and methods.Rosstat data obtained upon request were used. SDR was calculated using software (state registration number of computer program 216661114) using the European Standard Population using the direct standardization method per 100 thousand population; The average regional SDR values were calculated for the class of NSD and individual groups from this class, CVB (codes I60–69).

Results.A decrease in the regional average SDR from CVD was revealed among men (218.09 ± 60.81 in 2013 and 159.41 ± 51.20 per 100 thousand people in 2022) and women (144.30 ± 39.33 and 103.51 ± 32.63 respectively) and the increase in SDR from LBP (19.77 ± 17.70 and 65.99 ± 56.67 for men, 10.99 ± 11.32 and 52.81 ± 46.13 for women). Only in 4 regions was there a decrease in SDR from both NSD and CVD in both men and women. The dispersion of regional SDRs from NSD and CVB in 2022 compared to 2013 increased by more than 10 times, which indicates a significant and growing regional variability of indicators. In the stroke group, the most significant decrease occurred from “Stroke not specified as hemorrhage or infarction” (code I64). The regional average contribution of acute stroke (codes I60–64) to the SCS from NSD and CVB (in total) decreased (in 2013 among women 51.57 ± 16.26 %, in 2022 33.96 ± 14.95 %; among men 54.0 ± 15.01 and 39.82 ± 14.26 respectively). Alzheimer’s disease makes a negligible contribution to mortality; In men in certain regions, alcohol-associated LBP is significant.

Conclusions.Significant regional variability of SDR from individual groups of causes and a general trend towards a decrease in SDR from CVD and an increase in SDR from NSD were revealed, which is due to many factors. To eliminate the influence of different approaches to determining the cause of death, a unified protocol of criteria for their establishment is necessary.
Perancangan Karakter Superhero Pada Buku Ilustrasi Dengan Pola Suku Jawa dan Dayak
Authors: Fernando Anthony , Marwan Rudi Heri
Published: June 2024

Kajian ilmu desain dan visual sebagai masih relatif baru berkembang, memungkinakan upaya pengkajian dan penjelasan dalam budaya kontemporer yang sedang berkembang kini serta mengkaji juga budaya visual Indonesia yang telah berkembang. Kondisi tersebut digerakkan oleh perkembangan peradaban visual selama beberapa sepuluh tahun terakhir yang tidak lepas kebangkitannya oleh teknologi informatika dan komunikasi, sehingga penelusuran budaya visual tidak dapat lagi hanya dibatasi dari sesuatu yang tampak saja. Upaya untuk menggabungkan budaya lokal Indonesia dengan desain karakter modern. Dalam konteks ini, penelitian ini bertujuan untuk mengungkapkan proses perancangan yang menarik dan informatif melalui pengembangan buku ilustrasi. Melalui studi literatur, wawancara dengan narasumber terkait, dan observasi langsung, penelitian ini memfokuskan pada perancangan karakter superhero yang memadukan pola, aksesoris, dan pakaian budaya suku Jawa dan Dayak. Hasil yang ingin dicapai dari penelitian ini adalah buku desain karakter superhero dengan pola suku jawa dan dayak yang dirancang dengan ilustrasi visual agar dapat dipahami dan dimengerti serta meningkatkan pemahaman generasi muda terhadap warisan budaya lokal Indonesia. Hasil perancangan berupa buku yang mencakup pemberian identitas dan pembuatan sketsa awal, lineart, hingga ke tahap pewarnaan dan penyelesaian dengan ilustrasi yang menarik sehingga dapat menarik para khalayak.
“Misi dan Strategi Gereja: Penjangkauan Mahasiswa Non Teologi Sebagai Mitra Gereja Untuk Bermisi”
Authors: Bukit Pilemon
Published: June 2024

Many people when they hear the word mission, immediately think of a difficult, heavy and complicated job, because mission means having to go to someone else's country. In terms of mission and mission it doesn't have to be like that. Mission and mission means going to do something, in this case proclaiming that Jesus is Lord and the savior sent by God to mankind. For this mission, a strategy is needed and an effective and efficient strategy is to serve non-theological students to know and believe in Jesus and then develop it. With them they already know and believe in Jesus, so since they became students, they have been able to make missions on campus, in boarding houses, at their parents' homes, in churches and in their hometown during their holidays and especially after they have completed their education
Factors Contributing to Millennial Employees’ Turnover Rates
Authors:   Secretary to the Sanggunian, Municipality of San Fernando, Cebu City, P. Salmero Alan Jesus
Published: June 2024

Millennial employees in the bakeshop industry exhibited high turnover rates primarily due to the need for a safe work environment, recognition, and opportunities for promotion. The study focused on the factors contributing to millennial employees’ turnover rates. This study employed a quantitative, non-experimental, correlational design to investigate turnover intention among millennial employees in the bakeshop industry in Cebu Province. Data were collected via a researcher-made questionnaire from 34 randomly selected millennial employees. Analysis through descriptive statistics, chi-square tests, and weighted means revealed that millennials, who formed a significant portion of the working class, tended to leave their jobs if their specific needs were not met. The primary factor driving their turnover was self-preservation, with employees prioritizing a safe and healthy work environment. A workplace free from injuries and accidents not only attracted but also retained employees, leading to reduced absences and increased productivity. Consequently, a commitment to health and safety by employers enhanced employee retention and reduced business disruptions. Additionally, recognition and opportunities for promotion were crucial for retaining millennial employees. They were likely to leave if they felt undervalued or saw limited promotion opportunities. Training and development were less significant than promotions in influencing their decision to stay. The study also found that changes in management or internal talent management practices had minimal impact on retention, provided the work environment remained stable and employees were treated well. Overall, addressing millennials’ needs for safety, recognition, and career growth was vital for reducing turnover rates in the bakeshop industry.
Aplicación de la ley de Benford a la pesquería argentina de corvina rubia (Micropogonias furnieri)
Authors: García Sebastián , Rodríguez Julieta S. , Menna Bruno V.
Published: June 2024

En el ámbito de los datos estadísticos, tanto en las ciencias naturales como sociales, se ha observado que la distribución de los primeros, segundos y dos primeros dígitos en datos reales sigue frecuentemente un patrón conocido como la “ley de Benford”. Esta ley, ha sido utilizada recientemente como una herramienta para identificar anomalías en distintas bases de datos, sugiriendo en algunos casos la posibilidad de fraude. Se observó que los dígitos de datos “genuinos” tienden a seguir la ley, mientras que los dígitos de datos manipulados no lo hacen. En este trabajo, exploramos su aplicabilidad más allá del ámbito financiero, investigando si pueden detectar irregularidades en datos científicos, específicamente en la estadística oficial de captura de la pesquería argentina de corvina rubia (Micropogonias furnieri). Para tal fin, comparamos la frecuencia del primer, segundo y el primer par de dígitos de la captura con la distribución esperada, utilizando la desviación media absoluta (MAD). Implementamos una metodología basada en simulaciones de Monte Carlo y el test de Kolmogorov-Smirnov para calcular los valores críticos de la prueba de conformidad MAD, abordando la naturaleza única de los datos y la variabilidad en el tamaño de la muestra. El análisis realizado, sugirió la existencia de anomalías que podrían indicar patrones inusuales que merecen una investigación más detallada. En el ámbito de la evaluación, manejo/administración y conservación de los recursos pesqueros, la confiabilidad de los datos de captura es esencial. El uso de la ley de Benford, podría optimizar la selección de la información utilizada para elaborar indicadores y reducir la incertidumbre en la estimación del estado poblacional de los recursos.
Embracing Design Thinking to Navigate Complex Program Management Challenges
Authors:   USA, Deshpande Mahesh
Published: June 2024

This article explores the transformative potential of design thinking in navigating the complex challenges faced by program managers. By embracing the principles and strategies of design thinking, program managers can foster innovation, drive customer-centricity, and enhance adaptability in an increasingly dynamic business landscape. The article examines the key stages of the design thinking process, its applications in overcoming common program management challenges, and the strategies for implementing design thinking within organizations. Through practical insights, the article demonstrates how design thinking can be integrated into Agile methodologies, stakeholder engagement, and customer experience design to deliver superior program outcomes. The article concludes with a vision for the future of design thinking in program management and a call to action for program managers to adopt this approach as a core capability for success.
A Study on Public Sector and Private Sector Insurance in India
Authors: Tanmay Sarker
Published: June 2024

India’s insurance sector has been growing rapidly in the last decade. Different reforms have been implemented to stoke for the sector’s growth. But still has a long way to go, as its share in the global insurance market remains very low. It provides a link between the present and the future. Today India is one of the fastest growing economies of the world. According to the World GDP Ranking 2024 list, India is the fifth largest economy in the world. India is also fifth largest life insurance market in the world’s emerging insurance markets growing at a rate of 32-34% each year. Over the past nine years, the insurance sector has attracted substantial foreign direct investment amounting to nearly US$6.5 billion (Rs.54,000 crore), driven by the government’s progressive relaxation of overseas capita flow regulations. Insurance Industry is a growth-oriented industry. The life insurance sector in India has seen an array of changes in the past one decade. The economic scenario which emerged after globalization, privatization and liberalization has thrown a new challenge before the insurers. The present study is basically discussed regarding growth of private sector and public sector insurance of India, market share of public sector and private sector insurance and overall position of India’s public sector and private sector insurance.
Análisis de la formación académica de los jueces y su efecto en la administración de Justicia en el Perú
Authors: Paz Delgado Leonel Harry
Published: June 2024

The purpose of this article is to examine the academic training of Peruvian judges and how this influences the administration of justice in the country. To achieve this objective, a methodology was used that included the review of specialized literature, analysis of statistical data on the academic training of judges in Peru.
The research reveals that the academic training of Peruvian judges is varied and, in some cases, insufficient to face the challenges of the judicial system. The lack of specific training in key areas such as procedural law, criminal law and human rights is reflected in the quality of judicial decisions and in the population's perception of justice in the country.
In conclusion, the creation of a School of Judges in Peru is proposed that provides comprehensive and specialized training to aspiring judges, as well as continuing training programs for practicing judges. This school would not only guarantee the adequate preparation of judges to perform their duties effectively, but would also contribute to improving the quality and legitimacy of the Peruvian judicial system, thus strengthening the rule of law and democracy in the country.
Bitkilerdeki Antosiyaninlerin Etkinliği, Stabilitesi ve İn Vitro Üretimi
Authors: Onan Elif , Çölgeçen Hatice , Karahan Havva , Temiz Cengiz
Published: June 2024

Bitki sekonder metabolitlerinin büyük bir grubunu oluşturan antosiyaninler fenolik bileşikler sınıfının flavonoid grubuna ait pigmentlerdir. Antosiyaninler, angiyosperm grubu meyve, sebze ve çiçeklere; somon rengi dahil olmak üzere pembeden kırmızıya ve menekşeden koyu maviye kadar değişen birçok rengi veren bileşiklerdir. Antosiyaninler bitkilerde oksinleri taşıma, abiyotik ve biyotik streslere karşı kendini koruma, mikroorganizmalar için sinyalizasyon sağlama, patojenlerden korunma, tozlaşmayı sağlama gibi görevler üstlenmiştir. Sentetik renklendirici maddelere ve raf ömrünü artıran katkı maddelerine alternatif doğal bileşikler olan antosiyaninler, uzun zamandır geleneksel ekstraksiyon yöntemleri kullanılarak elde edilmektedir. Ancak mevsime bağlı bir üretim dalgalanması olması, sürekliliğin sağlanmasının güç olması, üretimi için çok fazla bitkisel materyale gereksinim duyulması, elde edilen ürünün saflık derecesinin ve kalitesinin düşük olması ise sınırlayıcı olmaktadır. Ayrıca nadir bulunan bitkilerin türünün tükenmesi tehlikesi de göz ardı edilmemelidir. Bu nedenle, antosiyaninlerin üretimi için laboratuvar koşullarında aynı özellikte, yüksek saflıkta, her daim üretilebilen ve başlangıç materyalinin az miktarda kullanıldığı biyoteknolojik yöntemler daha avantajlı olarak kabul edilmektedir. Biyoteknolojik metot olarak sıklıkla in vitro hücre ve kallus kültürü yöntemleri kullanılarak antosiyaninlerin üretimi gerçekleştirilebilir. Bu derlemede antosiyaninlerin bitkilerdeki etkinliği, in vitro üretimi ve stabilitesi incelenecektir.
Kıl Keçilerinin Vücut Ölçülerini Kullanarak Canlı Ağırlıklarını Tahmin Etmede Kısmi En Küçük Kareler ve Temel Bileşenler Regresyon Yöntemlerinin Karşılaştırılması
Authors: Akyürek Sağır Seda , Akkol Suna
Published: June 2024

Bu çalışmanın amacı, çoklu bağlantı probleminin varlığında kıl keçilerinde çeşitli vücut ölçüleri kullanılarak canlı ağırlıklarının tahmin edilmesinde Kısmi En Küçük Kareler (KEKK) ve Temel Bileşenler (TB) regresyon yöntemlerinin kullanılması ve çalışma verisi için en iyi tahmin yönteminin bulunarak sonuçların yorumlanması amaçlanmıştır. Bu amaçla, 119 baş dişi kıl keçisinden ölçümü yapılmış canlı ağırlıklar ve çeşitli vücut ölçüleri (cidago yüksekliği, sağrı yüksekliği, sırt yüksekliği, vücut uzunluğu, göğüs derinliği, göğüs genişliği ve göğüs çevresi) kullanılmıştır. 10 katmanlı çapraz doğrulama sonunda her iki yöntem için gizil faktör sayısı iki olmuştur. Açıklanan toplam varyans KEKK ile %82,10, TB ile %80,04 ve HKO sırasıyla 0,213 ve 0,230 olarak elde edilmiştir. Buna göre, kıl keçilerinde çeşitli vücut ölçüleri kullanılarak canlı ağırlığın tahmin edilmesinde toplam açıklanan varyasnın daha yüksek ve HKO’sının daha düşük olması nedeniyle KEKK, TB regresyon yönteminden daha güvenilir olduğu sonucuna ulaşılmıştır. Ancak her iki yöntemde canlı ağırlıktaki değişimi açıklamada en yüksek etkiye sahip olan değişken GC olarak bulunmuştur. Dolayısıyla kıl keçilerinde canlı ağırlık üzerinde yapılacak seleksiyon çalışmalarında GC’nin önemli bir kriter olduğu bu çalışmada ulaşılan diğer bir sonuçtur.
Green Synthesis of Chitosan-Coated Silver Nanoparticles (Ch-AgNPs): Harnessing Nature for Sustainable and Safe Nanomaterial Production
Authors: Kara Aslı , Özçelik Burçin
Published: June 2024

The production of silver nanoparticles (AgNPs) using green synthesis methods promotes the use of environmentally friendly materials and facilitates a more sustainable production process by reducing environmental impact. In addition, combining the metal nanoparticles with biopolymers are getting important to enhance the safety profiles of formulations to determine the biological activities. With this concept, AgNPs were synthesized by green synthesis method from Betula spp. tree branches as reported previously by us and in current study, synthesized AgNPs were coated by one of biopolymer. Herein, Chitosan was used as capping and stabilizing agent. Characterization of the biosynthesized silver nanoparticles (AgNPs) and Chitosan coated silver nanoparticles (Ch-AgNPs) were evaluated with various techniques. Through this analysis, it was elucidated that the phenolic compounds present in Betula extract and Chitosan played dual roles as both reducing and capping agents, facilitating the formation of Ch-AgNPs. Particular size analysis by dynamic light scattering (DLS) and scanning electron microscopy (SEM) indicated that the Ch-AgNPs ranged from 49 to 118 nm in size, with a narrow size distribution. X-Ray Differentiation (XRD) patterns confirmed the high crystallinity of the resulting particles. Fourier transform infrared (FTIR) analysis further supported these findings, revealing the involvement of phenolic compound extracts in both the formation and stabilization of AgNPs. Additionally, FTIR confirmed the surface modification of AgNPs by chitosan. The efficiency of surface modified Ch-AgNPs was compared with uncoated AgNPs for their antimicrobial activity, antiproliferative efficiency and biocompatibility. Cell culture studies demonstrated that AgNPs were less toxic to L929 cells while maintaining effective cytotoxicity against HT-29 cells. Moreover, surface modification with chitosan enhanced the toxicity of AgNPs against HT-29 cells Furthermore, the first synthesized and evaluated Ch-AgNPs with this study from Betula extract, exhibited potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. Our findings indicate that novel synthesized Ch-AgNPs formula may present a biocompatible and safety approach for further anticancer and antimicrobial studies.
SPIRITUAL WELL BEING DENGAN KUALITAS HIDUP PASIEN TUBERKULOSIS PARU
Authors: Ifa Nofalia  , Wibowo Suhendra
Published: June 2024

Tuberkulosis paru (TB paru) merupakan penyakit menular kronis yang berdampak signifikan pada berbagai aspek kehidupan pasien. Banyaknya dampak yang terjadi akan menyebabkan penurunan pada kualitas hidup pasien. Spiritual well-being dapat membuat seseorang menerima kondisi yang terjadi padanya sehingga diharapkan meningkatkan kualitas hidup. Tujuan penelitian ini adalah untuk mengetahui hubungan spiritual well-being dengan kualitas hidup pada pasien TB paru di Kecamatan Peterongan Kabupaten Jombang. Penelitian ini menggunakan metode kuantitatif observasional analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini berjumlah 192 pasien dengan sampel 130 responden dengan penarikan menggunakan teknik simple random sampling. Kuisioner Spiritual Well Being Scale (SWBS) digunakan untuk menilai spiritual well-being dan  World Health Organization Quality Of Life – BREF (WHOQOL-BREF) untuk mengukur kualitas hidup pada pasien. Metode analisis data yang digunakan adalah dengan menggunakan uji spearman rank. Hasil penelitian menunjukkan 57% responden memiliki tingkat spiritual well being tinggi. Sebanyak 61% responden memiliki kualitas hidup tinggi. Hasil uji korelasi spearman rank menunjukkan ada hubungan antara spiritual well being dengan kualitas hidup pada pasien tuberkulosis paru (p= 0,001). Oleh karena itu dalam memberikan asuhan keperawatan pada pasien tuberkulosis paru perlu diberikan intervensi untuk meningkatkan spiritual well-being sehingga kualitas hidup juga meningkat.
 
Pulmonary tuberculosis (pulmonary TB) is a chronic infectious disease that significantly impacts various aspects of patients' lives. The numerous effects of the disease can lead to a decrease in patients' quality of life. Spiritual well-being can help individuals accept their condition, improving their quality of life. This study aims to determine the relationship between spiritual well-being and quality of life in pulmonary TB patients in Peterongan District, Jombang Regency. This research employs a quantitative observational analytic method with a cross-sectional approach. The population in this study consisted of 192 patients, with a sample of 130 respondents selected using simple random sampling. The Spiritual Well-Being Scale (SWBS) was used to assess spiritual well-being, and the World Health Organization Quality Of Life – BREF (WHOQOL-BREF) was used to measure the quality of life in patients. Data analysis was conducted using the Spearman rank test. The results showed that 57% of respondents had a high level of spiritual well-being, and 61% had a high quality of life. The Spearman rank correlation test results indicated a relationship between spiritual well-being and quality of life in pulmonary TB patients (p=0.001). Therefore, nursing care for pulmonary TB patients should include interventions to enhance their spiritual well-being and improve their quality of life.
COGNITIVE BEHAVIOR THERAPY MENURUNKAN GEJALA DEPRESI PADA IBU POSTPARTUM
Authors: Muspitha Fitri Dia , Rophi Kristiyani Herda
Published: June 2024

Depresi postpartum merupakan sebuah gangguan mood yang dapat terjadi antara 2-6 minggu setelah melahirkan dan dapat berlangsung hingga satu tahun.  Gangguan ini dapat mempengaruhi kesehatan fisik dan psikologis pada ibu dan bayi. Salah satu intervensi yang efektif dalam mengurangi gejala depresi postpartum adalah Cognitive Behavior Therapy (CBT). CBT dapat mengatasi pola pikir dan perilaku yang tidak sehat, dengan penekanan pada keyakinan budaya tentang peran ibu. Penelitian ini bertujuan untuk menguji pengaruh CBT terhadap gejala depresi postpartun. Metode penelitian ini menggunakan desain quasi experiment dengan pre and post test one group without control group di Puskesmas Arso III, Kabupaten Keerom, Papua. Sampel penelitian berjumlah 20 responden yang dipilih dengan teknik purposive sampling. Pengukuran depresi postpartum menggunakan Edinburg postpartum depression scale (EPDS). Hasil penelitian menunjukan rata-rata skor depresi postpartum sebelum diberikan intervensi CBT adalah 11,4±0,5. Setelah diberikan intervensi CBT terjadi penurunan rata-rata skor depresi postpartum menjadi 7,0±0,79 (penurunan 4,4 poin). Hasil uji wilcoxon menunjukkan nilai p= 0,000, yang berarti penurunan skor depresi postpartum signifikan secara statistik. Terapi CBT dapat dilakukan untuk meningkatkan kesehatan fisik dan psikologis pada ibu dan bayi.
 
Postpartum depression is a mood disorder that can occur between 2 to 6 weeks after childbirth and may last up to 1 year. This disorder can affect the physical and psychological health of both the mother and the baby. One effective intervention for reducing postpartum depression symptoms is Cognitive Behavior Therapy (CBT). CBT can address unhealthy thought patterns and behaviors, with an emphasis on cultural beliefs about the role of the mother. This study aims to examine the effect of CBT on postpartum depression symptoms. This study uses a quasi-experimental design with pre-test and post-test in one group without a control group at Puskesmas Arso III, Keerom Regency, Papua. The sample consisted of 20 respondents selected using purposive sampling. Postpartum depression was measured using the Edinburgh Postpartum Depression Scale (EPDS). The results showed that the average postpartum depression score before the CBT intervention was 11.4±0.5. After the CBT intervention, the average postpartum depression score decreased to 7.0±0.79 (a reduction of 4.4 points). The Wilcoxon test results showed a p-value of 0.000, indicating that the decrease in postpartum depression scores was statistically significant. CBT can be implemented to improve both mother and baby's physical and psychological health.
The Mediating Effect of Quality of Work-Life on the Relationship Between Career Self-Management and Well-Being of Public-School Teachers
Authors: Eledio Allaniza , Ocay Raynard B.
Published: June 2024

This study determined the mediating effect of quality of work-life (QWL) on the relationship between career self-management and the well-being of public-school teachers in Carmen District, Davao del Norte, Philippines. A positive work environment fosters active participation in career self-management, ultimately leading to greater teacher well-being. Employing a quantitative descriptive-correlation design, the study surveyed 300 public elementary and high school teachers. Findings revealed high levels of career self-management, well-being, and QWL among teachers. Seeking advice emerged as the strongest indicator of career self-management, highlighting a collaborative learning culture. While teachers reported high work satisfaction and a strong sense of purpose, there is room for improvement in promoting teacher visibility within the professional community. Significant positive relationships were found between all three variables. This suggests that teachers who actively manage their careers experience greater well-being and perceive a higher quality of work life. Additionally, a positive work environment contributes to teachers’ overall well-being. The study further revealed a mediating effect of QWL, indicating that teachers’ proactive career management strategies partially influence their well-being through the quality of their work environment. With this, educational leaders can cultivate a supportive work environment by promoting teacher visibility, fostering a positive organizational culture, and providing adequate resources. By addressing these factors, educational institutions can enhance teacher well-being, ultimately leading to a thriving educational community and improved outcomes for all stakeholders.
Factors Determining the Service Performance of Government Employees: Lesson Learned from Indonesia
Authors: Ginting Helwin , Supriatna Tjahya , Hubeis Musa , Sulistyani Dewi , Firdausy Carunia Mulya
Published: June 2024

Limited studies examining the influence of budgeting and employee resources available in organizations on the service performance of government employees in Indonesia To fill this gap, this study aims to examine whether or not policy implementation, employee resources, budgeting, and infrastructure affect the service performance of government employees by taking one of the government office located in North Jakarta, the Capital City of Indonesia as a case study. A random sample of 131 government employees, community leaders, and the community members who received the government services was selected. Random sampling was used since it is generally less biased and more generalizable. The questionnaire instrument was distributed directly to the sample respondents at the government office in North Jakarta, the Capital City of Indonesia. The method to analyze the data was by using a multiple linear regression model as suggested in the literature. The results showed that the four factors of policy implementation, employee resources, budgeting, and infrastructure were found to positively and significantly affect the service performance of government employees in Indonesia. These findings may be considered lessons learned for other developing countries in improving the service performance of their government employees. It is now or never.
USO DA TECNOLOGIA NA EFICIÊNCIA ADMINISTRATIVA: AVALIAÇÃO DA PLATAFORMA PROESC NA GESTÃO ESCOLAR DA REDE PÚBLICA DE ENSINO DO MUNICÍPIO DE LARANJAL DO JARI-AP
Authors: Pinheiro da Silva Patrícia , Pinheiro da Silva Magda , Tavares dos Prazeres Hamilton
Published: June 2024

As plataformas digitais na educação têm como fator importante a centralização e segurança das informações, permitindo um acesso rápido e seguro a dados essenciais, o que contribui para uma tomada de decisão mais ágil e informada, além de promover uma comunicação mais eficaz entre professores, família, coordenadores e alunos. Diante disso, este estudo tem como objetivo identificar o impacto da plataforma PROESC na eficiência administrativa da gestão escolar da rede pública de ensino do município de Laranjal do Jari-AP. A metodologia foi baseada em uma abordagem quantitativa, cuja coleta de dados foi realizada através de pesquisa em fontes bibliográficas, observação e entrevistas semiestruturadas, por meio do Google Forms, com três coordenadores municipais que gerenciam a plataforma PROESC em Laranjal do Jari-AP. Nesse contexto, a relevância do estudo está no fato de o artigo contribuir com e conhecimento sobre esse sistema de gestão escolar. Semelhante a outras empresas, a escola precisa gerenciar seus recursos, contratar e dispensar funcionários, lidar com questões documentais e burocráticas e administrar as finanças da instituição. A partir dos resultados, pode-se concluir que é importante entender como essas tecnologias são implementadas e de que maneira estão contribuindo para a melhoria da qualidade da educação.
FarmTrend Insights: Harnessing Regression-Fuzzy Models for Farmer Economic Predictions
Authors: Chauhan Alok Singh
Published: June 2024

India, often referred to as an agricultural country, has 52% of its population engaged in agriculture. The agricultural sector's prosperity is heavily dependent on regional climatic conditions. Adverse weather events significantly impact farmers' economic stability, exacerbating existing pressures and contributing to high rates of farmer suicides. This paper proposes a novel solution: the integration of regression-fuzzy models for predicting the economic conditions of farmers. By utilizing historical weather data spanning the past decade, this model aims to forecast economic fluctuations and mortality rates among farmers. The primary objective is to reduce the mortality rate by providing accurate predictions based on weather impacts on crop production, specifically focusing on Kharif and Rabi seasons. Through the application of fuzzy clustering and rule generation, the model classifies farmers' economic conditions and assesses the influence of weather on their production. This approach offers actionable insights to enhance economic resilience and mitigate distress in the agricultural sector.