bluuebunny/crossref_metadata_2025 huggingface dataset:
MULTI OPTIMIZATION OF FRICTION STIR WELDING OF ALUMINIUM AA 6061 ALLOY USING TAGUCHI GREY CO RELATION
Authors: Omkar Tuniki
Published: January 2025

It is often observed that the parameter tables for machining provided by machine tool manufacturers fail to align with operator requirements and, at times, do not offer efficient guidelines as per the expectations of manufacturing engineers. Therefore, selecting suitable machining parameters is critical for achieving the desired output in any machining process. This study focuses on determining the optimal parametric settings during Friction Stir Welding (FSW) of Aluminium AA 6061 alloy. The process parameters considered include welding speed, axial force, and tool rotational speed, while the quality characteristics studied are tensile strength and tensile elongation. To optimize these parameters, the Taguchi method was employed to design the experiments. An (L9 (3^3)) orthogonal array was selected based on insights from pilot experiments and a thorough literature review. Significant process parameters influencing machining performance were identified using Analysis of Variance (ANOVA) and F-test values in conjunction with experimental results. Verification of the quality improvements achieved using these optimized parameters was performed, and the findings showed enhancements compared to the original setup parameters. Furthermore, linear regression models were developed to establish relationships between machining performance and the selected parameters. In addition to optimizing each parameter individually, multi-response optimization was conducted using Taguchi-Grey relational analysis to consider the combined effects of the process parameters. The results demonstrate an overall improvement in the quality characteristics of FSW for Aluminium AA 6061, validating the effectiveness of the optimized parametric settings.
LIPOSARCOMA OF THE COLON PRESENTING AS AN ENDOLUMINAL MASS
Authors: C.N Vysakh , Shajahan Y. , Balachandran Rejith
Published: January 2025

Background:Liposarcoma is one of the most common soft tissue sarcomas of adult life, usually occurring in the retroperitoneum and the extremities. Primary liposarcoma of the colon is very rare. The optimal treatment has not been established due to the small number of cases reported. We report a case of primary liposarcoma of the colon presenting as an intraluminal lesion.

Case presentation: A 47-year-old female presented with abdominal pain, loose stools and hematochezia associated with fatigue for 2 weeks duration. An ultrasonogram detected a heteroechoic lesion of size 3.8*4.4 cm in the epigastric region related to the bowel. A contrast enhanced computed tomography identified a well-defined predominantly fat attenuating lesion associated with transverse colon. The patient underwent surgical resection of the lesion with end-to-end colo-colic anastomosis. Pathologic examination was consistent with well differentiated liposarcoma of the colon.
Strategi kesiapsiagaaan menghadapi bencana di Perpustakaan UIN Mahmud Yunus Batusangkar
Authors: Wahyuni Sri , Manita Rika Jufriazia
Published: January 2025

Purpose. This study aims to determine the disaster preparedness carried out by the UIN Mahmud Yunus Batusangkar Library in disaster prevention. It is hoped that this study will be an important contribution to institutions regarding the need for a standard on disaster preparedness.
Methodology. The methods used in this research use qualitative methods. In data collection researchers use direct observation techniques, semi-structured interviews, and documentation.
Results and discussion. The preventive measures that the library has undertaken by organizing, training, and simulating disasters are usually held by the university every year and are dedicated only to K3 officers. In addition, the library's cooperation with local cooperating with the firefighters. Responsive action makes plans and rescue efforts collections at the UIN Mahmud Yunus Batusangkar Library, training, and disaster simulations are usually held by the university every year to occupational safety and health team. The repairs in 2009 in West Sumatra were devastated by an earthquake and caused the walls of the library to crack and the ceilings of the libraries to fall onto the shelves, as well as causing a lot of dust to burst into the books. To anticipate that, the library did a fumigation.
Conclusions. Overall, the library has planned optimal disaster preparedness, which is sourced from the provision of equipment and work safety training in dealing with disasters. As a recommendation from the author, it is expected to provide disaster response training for library managers so that they can respond quickly when a disaster occurs.
Tren penggunaan kecerdasan buatan dalam pembelajaran mahasiswa sarjana dan diploma Fakultas Ekonomi dan Bisnis Universitas Udayana
Authors: Cahyaningtyas Dwi Fitrina
Published: January 2025

Purpose. This study aims to explore the use of Chat AI and see the information search behavior patterns of students at the Faculty of Economics and Business, Udayana University.
Methodology. This research was conducted by survey with descriptive. The respondents were diploma and undergraduate students from the Faculty of Economics at Udayana University. The questionnaire was distributed through WhatsApp groups by filling out a google form and open questions.
Results and discussion. More than half of the students have utilized AI technology, particularly Chat AI, in their coursework to complete daily assignments. However, the information obtained through Chat AI is not yet fully trusted. Their information-seeking behavior tends to follow Ellis's model due to the relevance of the information to their needs.
Conclusions. The ease of obtaining information and time efficiency offered by AI has created a trend among students in their learning process. However, limitations on AI usage are necessary to maintain the integrity of higher education.
Portrait of Graduate Theology In Indonesia: The Conflict Between God's Needs and Self-Life Needs
Authors: GP Harianto , Ming David , Slamet Triadi  , Novita Loma Sahertian
Published: January 2025

The background study explores Portrait of Graduate Theology in Indonesia as it relates to the dilemma between serving God and your own needs, particularly in light of the increasing number of theology graduates and their employment challenges. The increase in the number of theology majors by 13% raises concerns, given that 42% of these graduates face unemployment. This situation highlights a significant gap in theological education, where the quality may not meet the job market demands. The objective research aims to understand how theological education can better prepare students for spiritual service and practical life needs. This research employs a literature review approach, examining existing theoretical frameworks and empirical data on the social dynamics surrounding theology graduates. It examines various customs, norms, and societal expectations influencing these graduates' educational experiences and career paths. The increasing number of theology graduates juxtaposed with high unemployment presents a critical challenge for theological education. By adopting holistic approaches integrating spiritual formation with practical applications, institutions can better prepare students to navigate their dual roles in serving God and fulfilling personal life needs. This alignment could ultimately reduce unemployment rates among theology graduates while enriching their contributions to society.
Rice Husk Ash: A Promising Heavy Metal Adsorbent For Wastewater Treatment
Authors: Kumalasari Meiyanti Ratna , Beladona Siti Unvaresi Misonia , Gracia Amanda Natania , Sugiyani Tina , Wulandari Oktavia Rahmi , Imelya Marsya , Syaima Husna , Hanif Qonita Awliya
Published: January 2025

The primary polluter of the environment is liquid waste. Silica is one substance that can be utilized to minimize water pollution. Silica can be produced from agricultural biomass waste, such as rice husk ash. This study investigated the preparation of rice husk ash and the optimal synthesis method for producing bio-silica. A literature review of studies on rice husk ash, heavy metals, and adsorbents was conducted. The findings indicated that boiling rice husk at 800°C and washing with HCl produced high-purity silica. XRD (X-ray diffraction), FT-IR (Fourier transform infrared) spectrophotometers, and ED-XRF (Energy Dispersive X-ray fluorescence) were employed to characterize the rice husk ash. The precipitation, sol-gel, acidification, and hydrothermal methods were compared for bio-silica synthesis. The synthesized bio-silica can be used as a heavy metal absorbent for various metal ions, including Pb2+, Zn2+, Mn2+, Cu2+, As3+, As5+, and Cd2+.
Characteristics of Liquid Sugar from Cassava Flour Using Gelatinization, Liquefaction and Enzymatic Saccharification (amyloglucosidase and α-amylase) Processes
Authors: Agustina Tika , Elsyana Vida , Alvita Livia Rhea , Ramandani Adityas Agung , Purnani Mawar Siti
Published: January 2025

Domestic sugar production is still insufficient to satisfy the national demand for sugar, and production costs are expensive. One of the ingredients that can be used to make liquid sugar is starch. This study aims to determine the response of the resulting reduced sugar by optimizing the substrate concentration, liquefaction, and saccharification time. The method used of Box Behnken Design (BBD) with combinations of 20, 30, and 40% substrate concentrations, liquefaction times of 20, 40, and 60 min, and saccharification times of 20, 40, and 60 min. The characteristics of cassava flour, such as moisture (9.208 ± 0.068%), ash (0.987 ± 0.001%), fiber (2.187 ± 0.033%), and starch (79.876 ± 0.000%), were satisfied on SNI 01-2905-1992. Liquid sugar made from cassava flour reduced the sugar content by 28.299 ± 0.101%. The optimal conditions were 40% substrate concentration, 60 min liquefaction time, and 60 min saccharification time. The characteristics of the validation liquid sugar are in accordance with the specifications for the quality requirements of SNI 01-2978-1992 in the form of moisture content, ash content, and reducing sugar of 5.194 ± 0.003%, 0.996 ± 0.000%, and 29.668 ± 0.761%, respectively. These results highlight the effectiveness of optimizing substrate concentration, liquefaction time, and saccharification time in producing high-quality liquid sugar from cassava flour. This optimization addresses the domestic demand for sugar. It provides a cost-effective solution by utilizing cassava flour, thereby supporting the local agricultural economy and potentially reducing reliance on imported sugar.
Effect of Surfactants on Total Phenol Content from Sonication Extraction of Moringa (Moringa oleifera Lamk) Leaves in Vegetable Oil
Authors: Azhar Istighfarin Meilidya , Mahmudah Rif'atul , Fasya Ahmad Ghanaim
Published: January 2025

This research aimed to determine the effect of variations in surfactant addition and sonication extraction time on the total phenolic content of Moringa leaves in vegetable oils, namely Virgin Coconut Oil (VCO) and Extra Virgin Olive Oil (EVOO). Moringa leaf extract in VCO and EVOO at varying volume additions of tween 80 of 0 mL; 0.1 mL; 0.2 mL; 0.3 mL; and 0.4 mL, as well as variations in extraction time, namely 0, 10, 20, and 30 minutes. The solution mixture was sonicated at room temperature with a frequency of 42 kHz. The extraction results were tested for total phenol content using the total phenol measurement method (Folin-Ciocalteu), whose absorption was measured using a UV-Vis Spectrophotometer. The best variation was the addition of tween 80 volume of 0.4 mL and extraction time of 30 minutes; sonicated Moringa leaf extract in VCO was 39.28 ± 1.75 mg GAE/g and EVOO was 57.80 ± 2.89 mg GAE/g. Furthermore, the typical functional groups of phenolic compounds in the best Moringa leaf herbal oil extract in VCO and EVOO were identified using an FTIR spectrophotometer.
Utilization Of Chlorella Pyrenoidosa As A Phytoremediator For Tannery Waste
Authors: Adetya Nais Pinta , Arifin Uma Fadzilia , Anggriyani Emiliana , Rachmawati Laili
Published: January 2025

This study aims to analyze the effect of phytoremediation on the bioremoval of COD, ammonia, and Cr (VI) from tannery wastewater and examine its effect on the growth of Chlorella populations. The research method consisted of two stages: first, preparation of liquid waste media. The second is culturing pure cultures followed by microalgae cultivation using leather tanning liquid waste media with a concentration variation of 0%, 10%, 20%, and 30% v/v. Filtrate samples after harvest were analyzed for COD, ammonia, and Cr (VI). The results obtained in this study show that Chlorella can grow in tanning waste media. The highest exponential phase occurs at a concentration of 20% with a growth rate of 0.557. Tannery liquid waste contains inorganic minerals utilized by Chlorella pyrenoidosa cells for growth. Cultivation of Chlorella pyrenoidosa can reduce leather tanning liquid waste parameters, namely COD, ammonia, and Cr (VI).
Beyond the Limits of Constructed Identity: Teeth as Deleuzoguattarian Partial Objects in Edgar Allan Poe’s “Berenice”
Authors:   Research Scholar, Dr B R Ambedkar National Institute of Technology Jalandhar, Shefali Ms , Puri Preeti ,   Assistant Professor, Department of Humanities and Social Sciences, National Institute of Technology Hamirpur
Published: January 2025

Critics who attempt to linearize the behavior of Edgar Allan Poe’s narrator, Egaeus, in “Berenice,” limit the potential for his self-expression by focusing solely on his relationship with his cousin’s teeth. This article explores the complex dynamics between the narrator and various objects within the narrative, using the Deleuzoguattarian concept of partial objects. It argues that the narrator’s fixation on Berenice’s teeth is not driven by a monomaniacal obsession or a fetish for a single object. Instead, it represents his effort to disrupt the logocentric structures that limit his bodily potential. The study investigates the factors that seek to appropriate the narrator’s body, showcasing his struggle between an imposed monomaniacal identity and an unrelenting desire to explore the world. Additionally, it examines how teeth, as nomadic partial objects, deconstruct the perception of an organism as a cohesive entity and help the narrator contest his monomaniacal identity.
Reproduction, Society and Modern Medicine: Unveiling the Intricacies of the Fertility Industry in India through the Movie Good Newwz (2019)
Authors:   Research Scholar, Department of Humanities and Management, Dr B R Ambedkar National Institute of Technology Jalandhar, Walia Anubhuti , Puri Preeti ,   Assistant Professor, Department of Humanities and Social Sciences, National Institute of Technology Hamirpur, Hamirpur
Published: January 2025

The article aims to discuss the intricacies of the fertility industry in India through Raj Mehta’s directorial debut, Good Newws (2019). The movie serves as a social commentary by building upon the tragic switching of sperms between two infertile couples who decide to undergo In Vitro Fertilization (IVF) treatment. The film thereby reveals how healthcare corporations capitalise on socio-cultural politics of reproduction to commodify and market infertility solutions, which is then followed by a consistent disregard for patient-centred care. Within this context, the paper examines three components of the fertility industry operating in India. It commences by employing a feminist and sociological perspective to expose the ways in which societal and cultural obligations to have a child motivate infertile couples to seek treatment at IVF clinics. The second section uses Barthe’s concept of signification to delineate the marketing strategies that fertility clinics employ to attract desperate couples into availing their services. Finally, through the lens of the care ethics theory, the third section then explores the commercially motivated doctor-patient relationship in the fertility industry, which is characterised by a consistent violation of care ethics. Consequently, the study concludes by positioning Good Newwz (2019) within the continuum of infertility-themed Bollywood films, bringing fresh subjects of IVF technology and marketing to the forefront of conversations to raise critical awareness about the exploitative practices prevalent in the Indian healthcare system.
Pro-renin Receptor (PRR) as a Target to Reduce Non-alcoholic Fatty Liver Disease Post Liver Transplantation
Authors: Khodashahi Rozita , Ferns Gordon A. , Aliakbarian Mohsen , Arjmand Mohammad-Hassan
Published: January 2025

Nonalcoholic fatty liver disease (NAFLD) is one of the main causes of chronic
liver disorders following liver transplantation. The prorenin receptor (PRR) plays a
role in glucose and lipid metabolism, and the hepatic dysregulation of PRR is associated
with the upregulation of several molecular pathways, such as the mammalian target of rapamycin
(mTOR) and Peroxisome proliferator-activated receptor (PPAR) that promotes
hepatic lipogenesis and leads to lipid accumulation in hepatocytes by upregulation of lipogenic
genes. PRR inhibition leads to a reduction in the hepatic expression of sortilin-1
and low-density lipoprotein receptor (LDLR) levels and down-regulation of pyruvate dehydrogenase
(PDH) and acetyl-CoA carboxylase (ACC) and reduces fatty acids synthesis
in hepatocytes. In addition, β-oxidation regulatory genes are upregulated by PRR inhibition
to attenuate liver lipid content and liver steatosis. This evidence suggests that
targeting the dysregulated hepatic PRR may be effective in reducing liver steatosis postliver
transplantation.
Probing the Molecular Mechanisms of Kratom's Antipsychotic Effects through a Multi-modal Computational Approach
Authors: Wimbarti Supra , Tallei Trina Ekawati , Kairupan B.H. Ralph , Kapantow Nova Hellen , Ekatanti Dewi , Fatriani Rizka , Kusuma Wisnu Ananta , - Fatimawali , Celik Ismail
Published: January 2025

Background:

Psychosis, marked by detachment from reality, includes symptoms like hallucinations
and delusions. Traditional herbal remedies like kratom are gaining attention for psychiatric conditions.
This was aimed at comprehending the molecular mechanisms of Kratom's antipsychotic effects utilizing a
multi-modal computational approach.

Materials and Methods:

This study employed network pharmacology followed by molecular docking and
molecular dynamics simulation study to investigate the potential antipsychotic properties of kratom compounds
by identifying their key molecular targets and interactions.

Results:

Compounds present in kratom interact with a variety of receptors and proteins that play a pivotal role
in neurotransmission, neurodevelopment, and cellular signaling. These interactions, particularly with dopamine
and serotonin receptors, various proteins, and pathways, suggest a complex influence on psychiatric
conditions. Both mitragynine and zotepine (an atypical antipsychotic drug) display significant binding affinities
for 5HTR2A receptors, suggesting their potential for modulating related physiological pathways. Mitragynine
displayed higher flexibility in binding compared to zotepine, which showed a more stable interaction.
Hydrogen bond analysis revealed a more variable interaction profile for mitragynine than zotepine.

Conclusion:

The research findings suggest that the interaction between kratom compounds and essential brain
receptors could influence psychiatric conditions. Notably, both mitragynine (a key kratom component) and
zotepine (an antipsychotic) bind to the 5HTR2A receptor, suggesting the potential for kratom to modulate
similar pathways. Interestingly, mitragynine's flexible binding mode compared to zotepine might indicate a
more diverse range of effects. Overall, the findings suggest complex interactions between kratom and the
brain's signaling system, warranting further investigation into its potential therapeutic effects.
Metal-catalyzed Synthesis of Phenanthrene and its Derivatives: A Core Structure of various Natural Products
Authors: Samanta Khokan , Bera Sachinath , Dewan Mitali , Mandal Basudev , Samanta Shubhankar , Kundu Debasish , Jana Rathin
Published: January 2025

Phenanthrenes and their dihydro derivatives have attracted considerable attention due to their widespread
occurrence in natural products and pharmaceuticals with biological activities, which have led to their
application in the treatment of microbial or viral infections, allergies, cancer, and malaria. Nowadays, the transitional
metal-catalysed reactions are useful approaches for the synthetic transformation of organic compounds
due to high yield and step economy. This approach, owing to the use of non-pre functionalized substrates, minimizes
the chemical wastes. Among the various synthetic strategies, metal-catalyzed C-H bond activation and
also Heck reactions have recently drawn a lot of interest in synthesizing decorated π-conjugated polycyclic
aromatic hydrocarbon. In this review, we have focused on recent progress along with previous strategies to
synthesize various phenanthrene and its derivatives by the use of metal-catalyzed reactions and also discussed
the mechanistic details of the reaction.
PPA1, TRIM68 and FBXO46: Potential Therapeutic Targets for Triple Negative Breast Cancer
Authors: Haider Fatima , Syed Nida , Jaffari Syeda Abiha Zehra , Syed Basir , Ahmed Aftab , Zarina Shamshad , Hashim Zehra
Published: January 2025

Background:

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer
with a high recurrence rate. A new therapeutic intervention is urgently needed to combat this
lethal subtype. The identification of biomarkers is also crucial for improving outcomes in TNBC.

Method:

The cell cytotoxicity of ML364 (2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-
2-yl)-4-(trifluoromethyl)benzamide) was measured at different concentrations of ML364 in
TNBC-treated and untreated cells. The 2DE and LC-MS/MS analysis were used for protein identification
of differentially expressed proteins. Furthermore, the quantitation of gene expression was
demonstrated using RT-qPCR. TIMER, HPA, and UALCAN databases were utilized for further
analysis.

Results:

Differentially expressed proteins and genes after ML364 treatment in TNBC were found
to be linked with the USP2 (ubiquitin specific peptidase 2)-mediated pathway. Our results demonstrate
that differentially identified proteins, including PPA1, TRIM68, and FBXO46, could be a potential
prognostic biomarker for TNBC. Further analysis through the UALCAN and HPA
databasess showsthe high expression of these proteins in primary breast tumors, which is in contrast
to normal. The induction of ML364 significantly reduced the expression of PPA1, TRIM68,
and FBXO46 proteins and induced cell cytotoxicity in TNBC cells.

Conclusion:

This study provides an understanding of the USP2-mediated signaling pathway in
TNBC, emphasizing the role of USP2 and its substrates with apoptotic genes. Our results offer insight
into the USP2-mediated cellular mechanism after ML364 treatment in TNBC that could be a
potential therapeutic candidate.
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease
Authors: Roy Sagor Kumar , Barman Ashima , Sarkar Kumary Labone , Richard Seidu A , Lacmane Bijal Arvinkumar
Published: January 2025

“Huntington's disease” (HD) is an autosomal dominant hereditary neurodegenerative
disease characterized by defects in efferent striatal neurons, cortical neurons, and the basal ganglia.
The pathogenesis of HD is still unclear, and there is currently no curative therapy for this disorder.
This review emphasizes the potential beneficial effects of various neurotrophic factors in
HD. PubMed, Web of Science, Embase, and google scholar databases were used to search for all
studies on the efficacy of neurotrophic factors in HD. Several gene therapy strategies have been
employed to treat HD, including gene therapy with a variety of neuroprotective factors. Moreover,
a wide variability of gene therapy approaches such as a neurotrophin, has shown promising results
for both prevention and neuroprotection in HD, which may be due to their potential to prevent neuronal
cell death or decrease neurodegeneration, thereby promoting the growth of innovative axons,
dendrites, and synapses leading to improvement of HD. Neurotrophic factors may be suitable
as neuroprotective therapy agents in HD. Therefore, substantial research on gene therapy should
be conducted to provide better treatment options for HD in the future.
Impact of Copper(II) and Silver(I) Complexes Containing 1,10-Phenanthroline-5,6-dione on Cellular and Virulence Aspects of Scedosporium apiospermum
Authors: Pereira de Mello Thaís , A. Silva Bianca , Lione Viviane , Devereux Michael , McCann Malachy , Branquinha Marta Helena , Luis Souza dos Santos André
Published: January 2025

Background:

Scedosporium apiospermum is a multidrug-resistant filamentous fungus
that causes localized and disseminated diseases. Our group has previously described that metalbased
complexes containing copper(II) or silver(I) ions complexed with 1,10-phenanthroline-5,6-
dione (phendione) inhibited the viability of S. apiospermum conidial cells.

Objective:

The effects of these promising complexes, [Cu(phendione)3](ClO4)2.4H2O (Cuphendione)
and [Ag(phendione)2]ClO4 (Ag-phendione), on vital biological processes, production of
key virulence attributes and interaction events of S. apiospermum were investigated using a comprehensive
multimodal approach.

Results:

The results demonstrated that both Cu-phendione and Ag-phendione effectively inhibited
the viability of S. apiospermum mycelial cells in a dose-dependent manner. Furthermore, these test
complexes, at varying concentrations, inhibited the transition of S. apiospermum conidia into hyphae.
Scanning electron microscopy revealed significant structural alterations in the fungal cells,
including changes to surface sculpturing and overall morphological architecture, following treatment
with the complexes. A marked reduction in the expression of key surface molecules, such as
mannose/glucose-rich glycoconjugates, fibronectin-binding proteins, and the well-known adhesin
peptidorhamnomannan further supported these ultrastructural changes. The treatment also impaired
adhesive interactions, reducing the fungus's ability to form biofilms on polystyrene surfaces and
diminishing its interaction with macrophages, lung epithelial cells, and fibroblasts. Notably, treatment
of infected macrophages with the complexes led to a significant reduction in the number of
intracellular fungal cells.

Conclusion:

The results provide information about the effects of silver- and copper-phendione
complexes on cellular and virulence aspects of the emerging fungus S. apiospermum.

conclusion:

Collectively, the results presented herein add information about the promising effects of silver- and copper-phendione complexes on cellular and virulence aspects of the emergent, multidrug-resistant fungus S. apiospermum
Updates on Recent Advances in the Therapy of Adult Psoriatic Disease
Authors: Kharouf Fadi , Gladman Dafna D
Published: January 2025

Psoriatic arthritis (PsA) is a heterogeneous inflammatory disease with various joint and
skin manifestations and multiple associated comorbidities. The management of PsA is important
not only in controlling disease activity and preventing subsequent damage but also in improving
the quality of life and reducing mortality. Over the years, numerous drugs have been introduced into
the therapeutic armamentarium of the disease. While non-steroidal anti-inflammatory drugs (NSAIDs)
and conventional synthetic disease-modifying anti-rheumatic drugs (DMARDs) have contributed
to management, it was not until the advent of biologics (and later on targeted synthetic
DMARDs) that therapy was revolutionized, with the achievement of significantly better clinical
and radiographic outcomes. Several drugs and treatment approaches are currently being tested in
clinical trials at different phases. Despite all the success, there are still various challenges and unmet
needs in the field of PsA, reflected by difficult-to-treat disease course, secondary failure of
therapy, and lack of consensus on accepted treatment withdrawal protocols, among others.
In this review, we have discussed the most recent advances in the therapy of psoriatic disease,
with a particular focus on phase III studies completed (or ongoing) since 2020. We also mentioned
the challenges and unmet needs in our clinical practice, which we expect current and future
research to provide answers to.
Detection of Anti-drug Antibodies (ADAs) to an Antibody-drug Conjugate (ADC) PYX-201 in Human Plasma Using a Novel Electrochemiluminescence
(ECL) Immunoassay
Authors: Yin Feng , Adhikari Diana , Lara Rojo Ana , Kelly Laura , Ibdah Areeg , Orbegoso Ivan , Eak Gwen , Merriman Chengfeng , Feng Jianwen , Trexler Kristen , Turner Dunford Ann , Ospina Roxana , Dyszel Mike , Harriman Shawn , Pinkas Jan
Published: January 2025

Background:

PYX-201 is an Antibody-Drug Conjugate (ADC) composed of a fully human
IgG1 antibody, a cleavable linker mcValCitPABC, and toxic auristatin payloads Aur0101, with
a drug antibody ratio (DAR) of approximately 4. PYX-201 is a promising candidate for oncology
treatment because it targets the extra domain B splice variant of fibronectin (EDB + FN), which is
expressed at low levels in normal adult tissues while at moderate or high levels in various human
solid tumors.

Methods:

An electrochemiluminescence (ECL) immunoassay was developed and validated for the
detection (screening, confirmatory, and titration) of antibodies to an ADC PYX-201 in human plasma.
Anti-PYX-201 antibodies were captured by biotinylated PYX-201 (Bio-PYX-201) and detected
by ruthenylated PYX-201 (Ru-PYX-201) on a Meso Sector imager S 600 or 6000 reader.

Results:

The screening cut-point factor (SCPF), confirmatory cut-point (CCP), and titration cut-point
factor (TCPF) were found to be 1.11, 20.7%, and 1.23, respectively. Sensitivity was determined to be
2.25 ng/mL in the screening assay and 5.34 ng/mL in the confirmatory assay for anti-PYX-201 antibodies.
Sensitivity was determined to be 7.70 ng/mL in the confirmatory assay for anti-PYX-201
monoclonal antibody (mAb) antibodies. The positive controls (PCs) were set at the following levels:
low positive control (LPC) at 14.0 ng/mL, medium positive control (MPC) at 100 ng/mL, and high
positive control (HPC) at 5,000 ng/mL. The drug tolerance was up to 200 μg/mL at the HPC level,
up to 100 μg/mL at the MPC level, and 0 μg/mL at the LPC level. The intra-assay percent coefficient
of variation (%CV) was ≤ 4.5% for PCs in the screening assay and ≤ 11.5% for PCs in the confirmatory
assay. The inter-assay %CV was ≤ 13.6% for PCs in the screening assay and ≤ 19.2% for PCs in
the confirmatory assay. No hook effect, hemolysis effect, or lipemia effect was found in this ADA
method. Anti-PYX-201 antibodies were found stable in human plasma for at least 24 hours at room
temperature or after six freeze/thaw cycles.

Conclusion:

Anti-PYX-201 ADA bioanalytical method validation was reported for the first time in
any biological matrix. This ADA method has been successfully applied to human sample analysis to
support a clinical study.
An Updated Review on Dysregulated lncRNAs and their Contribution to the Various Molecular Types of Lung Carcinoma
Authors: Dastmalchi Narges , Alipour Mohammad Reza , Safaralizadeh Reza , Hajiasgharzadeh Khalil
Published: January 2025

Lung cancer is correlated with a high death rate, with approximately 1.8 million mortality cases reported
worldwide in 2022. Despite development in the control of lung cancer, most cases are detected at higher stages
with short survival rates. This reveals a need to recognize novel techniques to treat malignancy and decrease the
burden of lung cancer. Long noncoding RNAs (lncRNAs) manage vital cellular and biochemical functions.
lncRNAs play crucial roles in transcriptional and translational processes and signaling cascades. Recently,
lncRNAs have been reported to be associated with malignancy where their expression is deregulated, leading to
abnormal cellular activities and signaling pathways. In various malignancies, including lung cancer, lncRNA
deregulation disrupts normal cellular function, promoting tumorigenesis and influencing patient outcomes and
treatment responses. Studies have shown that lncRNAs can act as both oncogenes and tumor suppressors, depending
on the lung cancer subtype, specifically in Non-small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer
(SCLC). This dual role of lncRNAs as critical biomarkers might provide insights into lung cancer development
and progression. lncRNAs have been discussed as key biomarkers in lung cancer. A comprehensive understanding
of the biological activities of lncRNAs in NSCLC and SCLC may improve prognosis, diagnosis, and
therapeutic methods. Researchers are increasingly interested in lncRNAs as potential diagnostic biomarkers and
therapeutic targets in cancer treatment. As researchers continue to explore lncRNAs, their pivotal roles in lung
cancer become increasingly evident. This review highlights the function of lncRNAs in lung carcinogenesis and
discusses their molecular mechanisms of function.
Investigating the Prevalence of Suicidal Risk and Associated Risk Factors Among University Students in Southeastern Iran: A Cross-Sectional Study
Authors: Mehni Esmaeil Barkhori , Raesi Rasoul , Ahmadidarrehsima Sudabeh , Domari Asma Amiri , Amiri Mohammad Moqaddasi , Ardaneh Mahdieh , Hushmandi Kiavash , daneshi salman
Published: January 2025

Background:

Suicide is a significant health issue among young people
globally. According to available statistics and research, it ranks as the third leading
cause of death for individuals aged 15-24 and the second leading cause of death
among students.

Aim:

This study was conducted to investigate the risk of suicide and its related
factors among students at Jiroft University of Medical Sciences.

Methods:

The descriptive study of the current analysis is a cross-sectional type that
was conducted using a multi-stage sampling method on 128 students at Jiroft
University of Medical Sciences in 2022. Data were collected using the Beck Scale for
Suicide Ideation (BSSI) and analyzed with statistical tests of analysis of variance,
Pearson correlation, and multiple regression analysis in SPSS-24 statistical software.

Results:

The average age of students was 22.14 ± 2.96 years. Seventeen individuals
(13.3%) had a history of suicide attempts. The average suicide risk score was 6.18 ±
5.61, indicating a high risk of suicide among students. The suicide risk score differed
between individuals with strong religious beliefs and those with little belief
(p=0.025). The average score for suicidal risks was lower in individuals with
complete religious beliefs.

Conclusion:

The study shows that students are at a high risk of suicide. This
highlights the need to prioritize mental health, implement effective suicide prevention
strategies, and personalize interventions to reduce the risk of suicide among medical
students.
Characterization and Identification of Oleaginous Microalgae Isolated from Fresh Water for Biodiesel Production
Authors: Jaithaliya Radhika , Jain Divya , Chakraborty Dipjyoti , Dutt Kakoli
Published: January 2025

Introduction:

Developing sustainable biodiesel production relies on investigating local
microalgal populations to detect neutral lipid accumulation via high throughput screening. Method:
This study evaluates the efficacy of using various isolation strategies for maximizing microalgal
strain collection from low-abundance water samples.

Result:

The study resulted in the isolation of twenty-five algal strains, of which 3 oleaginous strains
were identified as Chlorococcum aquaticum BB607, Chlorococcum sp. BB601 and Spongiosarcinopsis
limneus BG607 were selected. Isolate C. aquaticum BB607 exhibited substantial lipid content
of 456.45 ± 2.40 μg/mL, lipid productivity of 38.04 ± 0.20 μg/mL/day, biomass yield of 4.23 ± 0.06
mg/mL and maximum percentage C16-C18 fatty acid profile compared to the other two isolates.

Conclusion:

Further, the FAMEs produced from this isolate exhibited high CN (60.384), low iodine
value (97.33 g I2/100 g) and negative cold filter plugging point (- 2.28°C). This demonstrates the
potential of C. aquaticum strain BB607 as a feedstock biodiesel production.
Cause Analysis of Rotork Electric Actuator Phase Loss Fault Mode
Authors: Li Jian , Hu Xiaoguang , Gao Zhigang , Niu Pingjuan , Guo Jingying , Lin Sixuan , Yan Zhike , Ren Hao , Zhang Hai , Liu Hairui , Song Yinglu , Song Shen , Zhu Leilei , Yang Chao
Published: January 2025

Background:

The stable, safe, and reliable operation of the electric actuator valve system is
crucial in industrial production. However, its faults can lead to production interruptions, equipment
damage, and increased costs. Therefore, detecting and analyzing the causes of fault modes is crucial for
exploring methods to reduce their occurrence and ensuring the normal operation of electric actuators.

Methods:

Taking the IQ20-F14-A electric actuator from Rotork, UK, as a reference, this paper
analyzes the causes of the phase loss fault mode from three aspects: software, circuitry, and external
conditions. By analyzing and experimentally testing the power supply information extraction
circuit, identifying the extraction signal related to phase information, and further comprehensively
listing the factors that lead to phase loss faults, the scope is narrowed down through analysis and
practical verification.

Results:

After investigating potential factors related to component design, circuit design, and connection
issues within the circuit, causing a decay of a certain phase voltage on the power line to
below the threshold leads to the optocoupler and information-extracting transistors entering a cutoff
state, resulting in a phase loss alarm. Additionally, the continuous superposition of typical interference
pulse trains on the input voltage for 9 seconds or more also triggers a phase loss alarm.

Conclusion:

The fault mode mainly revolves around software, the decay of external supply phase
voltage, and the interference of external phase voltage.
PENCEGAHAN RADIKALISME DAN TERORISME MELALUI KERANGKA KONTRA RADIKALISME BAGI PELAJAR SMA MALANG
Authors: Abdullah  , Warda Abidin  , Satria Akbar Pangestu  , Dinar Ayu Sekar Pawening
Published: January 2025

Seiring berkembangnya zaman, terutama di era globalisasi ini membuat tantangan yang dihadapi oleh negara-negara juga semakin kompleks. Salah satunya adalah tersebarnya pemikiran untuk melakukan aksi radikal dan teror kepada masyarakat. Radikalisme sendiri memiliki arti sebuah paham yang kolot, ekstrem, dan menormalisasikan tindakan kekerasan untuk mencapai tujuannya. Sedangkan terorisme memiliki arti tindakan menakut-nakuti dalam skala yang berat dan jumlah korban yang masif seperti pengeboman di ruang publik. Di Indonesia memiliki lembaga khusus yaitu Badan Nasional Penanggulangan Terorisme (BNPT) yang merupakan entitas yang berwenang untuk menyusun kebijakan dan membentuk strategi untuk menanggulangi tindakan terorisme dan radikalisme melalui kerangka kontra radikalisme. Pengabdian masyarakat ini kemudian dilaksanakan dalam upaya untuk menjawab tantangan serta permasalahan yang muncul dari upaya-upaya yang dilaksanakan untuk mencapai agenda pendidikan dalam SDGs. Penelitian ini menggunakan metode kuantitatif dengan desain survei untuk mengukur pemahaman siswa terhadap radikalisme dan terorisme sebelum dan sesudah kegiatan program pengabdian berlangsung. Kegiatan pengabdian dimulai dari pemberian pre-test, kemudian dilanjutkan dengan pemberian materi kepada peserta dan diakhiri dengan post test serta sesi role play. Kesimpulan dari hasil post-test yang diberikan adalah secara keseluruhan para siswa-siswi dapat memberikan jawaban post-test sesuai dengan materi yang disampaikan. Selain itu, jumlah jawaban kosong juga menurun drastis jika dibandingkan dengan pre-test. pengetahuan siswa tentang upaya pencegahan radikalisme dan terorisme ditemukan sangat meningkat. Hal ini dapat disimpulkan, bahwa peserta kini mampu memahami konsep kontra radikalisme dan membentuk rasa solidaritas serta membuat kampanye sederhana berdasarkan isu workshop ini.
Sztuczna inteligencja – zagrożenie czy bezpieczeństwo?
Authors: Bugajski Jarosław
Published: January 2025

Postęp technologiczny na przestrzeni ostatnich lat doprowadził do wysokiego rozwoju sztucznej inteligencji (SI), która niesie ze sobą wiele pozytywnych aspektów, ale jednocześnie może doprowadzić do naruszenia praw podstawowych jednostek i tym samym zagrozić bezpieczeństwu społecznemu. Wychodząc zatem od zagadnień związanych z rozwojem i zagrożeniami ze strony SI, podjęta została analiza prawna polityki regulacyjnej w odniesieniu do praw człowieka.
Internet Rzeczy – zastosowanie, zagrożenia, bezpieczeństwo
Authors: Ciemcioch Krzysztof
Published: January 2025

Pojęcie Internet Rzeczy jest znane od początku XXI wieku, lecz mimo wielu zalet tej technologii wynikającej z jej użytkowania i wykorzystania, wciąż pozostaje spora grupa osób, która nie zdaje sobie sprawy, że korzystając ze smart urządzeń, tak naprawdę korzystają z najnowszych rozwiązań wchodzących w skład IoT. Celem artykułu jest zaprezentowanie zebranych informacji o Internecie Rzeczy, jego zastosowaniu i implementacji w różnych gałęziach gospodarki i korzyściach dla użytkowników w życiu codziennym. Kolejnym celem jest również identyfikacja zagrożeń IoT, wpływających na nasze bezpieczeństwo oraz samo zabezpieczanie przetwarzanych zbieranych danych.
Badania kryminalistyczne w zakresie wizualizacji śladów daktyloskopijnych
Authors: Wojtyczka Władysław
Published: January 2025

W kryminalistycznych badaniach daktyloskopijnych dużą wagę przykłada się do poszukiwania nowych rozwiązań i udoskonalania sprawdzonych metod ujawniania śladów daktyloskopijnych. W większości przypadków ślady daktyloskopijne nie są widoczne gołym okiem i wymagają zastosowania odpowiedniej techniki wizualizacji. Na miejscu zdarzenia policjanci techniki kryminalistycznej wykorzystują do tego celu proszki daktyloskopijne, których skuteczność uzależniona jest od rodzaju podłoża i czasu jaki upłyną od momentu pozostawienia śladów. W praktyce proszki stosowane są do ujawniania śladów na dużych, gładkich powierzchniach i tych których nie można zabezpieczyć w całości. W trakcie czynności procesowych policjanci dążą do tego żeby przedmioty, które mogą mieć związek ze zdarzeniem zabezpieczać w całości, a następnie w warunkach laboratoryjnych dokonywać ujawniania śladów. To właśnie w laboratorium możliwa jest wszechstronna analiza materiału dowodowego i wybranie skutecznej metody ujawnienia śladów. Ważnym elementem jest również możliwość przeprowadzenia badań kompleksowych w celu uzyskania maksymalnej ilości informacji z przekazanego do badań materiału. Czynności te wymagają wiedzy, doświadczenia i ścisłej współpracy podczas stosowania skutecznych metod badawczych, a także umiejętności przy podejmowaniu decyzji na temat kolejności pobierania próbek i przeprowadzania ich analiz.
Wspomaganie kształtowania postawy patriotycznej wśród dzieci w wieku wczesnoszkolnym z wykorzystaniem nowoczesnych technologii na przykładzie strony internetowej „Witaj w Polsce”
Authors: Czapczyk Dagmara , Dąbrowska Wiktoria
Published: January 2025

W dobie dynamicznych zmian społecznych i technologicznych oraz wyzwań współczesnego świata formy realizacji edukacji regionalnej ulegają innowacyjnym zmianom. Z jednej strony wskazaną edukację możemy realizować korzystając z nieograniczonych zasobów obiektów kulturalnych – muzeów, domów kultury czy centrów sztuki. Interesującym rozwiązaniem jest również wprowadzenie technologii do sali lekcyjnej, które niesie za sobą szereg możliwości potencjalnego zapoznania z tradycjami regionalnymi. Wyselekcjonowana w toku analiz oraz zaprezentowana strona internetowa może pomóc nauczycielom w efektywnym przekazaniu treści z zakresu edukacji społecznej. Dzięki atrakcyjnym materiałom graficznym i dźwiękowym możemy zaznajomić społeczność uczniowską z charakterystyką poszczególnych regionów ojczyzny, a tym samym zachęcić ich do samodzielnego odkrywania różnorodnych obszarów Polski.
Rzeczywistość wirtualna w terapii zaburzeń przetwarzania sensorycznego
Authors: Majewska Kamila , Kamper-Kubańska Monika
Published: January 2025

Rzeczywistość wirtualna coraz częściej stosowana jest w terapii zaburzeń przetwarzania sensorycznego. Odpowiednio dobrane oprogramowanie wraz goglami VR i dodatkowym oprzyrządowaniem rehabilitacyjnym sprzyjają pobudzaniu zmysłów oraz ich integracji, co w sposób wartościowy uwidacznia się w procesie terapeutycznym. Artykuł stanowi przegląd wyników badań lokujących się w tym obszarze. Pomaga zrozumieć przyczyny oraz korzyści wynikające z włączenia gogli VR do procesu terapii sensorycznej.
Nowoczesne technologie wykorzystywane w domach pomocy społecznej
Authors: Banasiak Małgorzata , Wołowska Agata , Ciesielski Jacek
Published: January 2025

Artykuł porusza kwestie nowych technologii wykorzystywanych w służbie drugiego człowieka, a szczególnie w opiece nad seniorami i osobami somatycznie chorymi. W artykule znaleźć można informacje na temat innowacji technologicznych, które znajdują zastosowanie zarówno w odniesieniu do sfery emocjonalno-społecznej (foka „Paro”), jak do zaspokajania potrzeb fizjologicznych (inteligentna szklanka, pieluchomajtki z sensorem przepełnienia).
Macierzyństwo w mediach społecznościowych – analiza zjawiska
Authors: Łazińska Julia
Published: January 2025

Niniejszy artykuł poświęcony jest analizie problematyki macierzyństwa poruszanej w mediach społecznościowych, a analizowanej z perspektywy matek (aktywnych w mediach społecznościowych), zarówno w okresie ciąży, jak i do 3. roku życia dziecka. Praca skupia się na analizie aktywności matek na portalach takich jak Facebook i Instagram, a także zawiera informacje dotyczące zagrożeń zarówno dla samych matek, jak i ich dzieci, jako skutek korzystania z platform społecznościowych. Ponadto praca przedstawia wyniki badań własnych przeprowadzonych metodą ilościową, z wykorzystaniem anonimowej ankiety przeprowadzonej online na próbie 76 kobiet. Badanie ukazało perspektywę matek dzieci do 3. roku życia funkcjonujących w środowisku mediów społecznościowych.
Odległość między nauczycielem-uczniem a wpływ na relacje uczeń-uczeń w trakcie realizacji wybranych programów edukacyjnych
Authors: Mikulski Kazimierz
Published: January 2025

W latach 2013–2023 zrealizowano badania związane z nauczaniem informatyki i jej części składowych w edukacji szkolnej w kontekście proksemiki. Wyniki ujęto w monografiach: „Proksemika cyfrowej szkoły”, „Nauczyciel przestrzeni cyfrowej w kontekście proksemiki” i „Nauczanie programowania w kontekście proksemiki” oraz „Robotyka w edukacji w kontekście proksemiki”, a także „Kompetencje cyfrowe w edukacji w kontekście proksemiki” i „Aktywna tablica w edukacji w kontekście proksemiki”. W przywołanym obszarze zakończone zostało także badanie „Laboratoria przyszłości w edukacji w kontekście proksemiki”. Dogłębna analiza wskazanych pozycji uświadamia, że otrzymane wyniki badań powinny być rekomendowane do wykorzystania zarówno przez nauczycieli, jak i producentów pomocy dydaktycznych. Działanie to prawdopodobnie będzie sprzyjać podniesieniu efektów pracy w procesie edukacyjnym, co jest zgodne z oczekiwaniami środowiska oświatowego.