bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Microwave-Assisted Drying to Shorten Granules Drying Process for the Preparation of Thunbergia laurifolia Lindl. Leaf Tablets
Authors: Suksaeree Jirapornchai , Monton Chaowalit , Chankana Natawat , Charoenchai Laksana
Published: March 2023

Thunbergia laurifolia Lindl. is a medicinal plant that belongs to the family of Acanthaceae. It possesses several biological and pharmacological activities. According to the Thai National List of Essential Medicines, T. laurifolia leaves are used for the treatment of fever. This work sought to optimize microwave-assisted drying of Thunbergia laurifolia Lindl. leaf granules to shorten the granule drying process by the 32 full factorial design. Power was varied from 300, 450 and 600 W for 5, 10 and 15 min, to minimize moisture content and maximize rosmarinic acid content. Results showed that the optimal microwave-assisted drying condition within the design space and control space was the power of 450 W for 13 min. This condition gave the moisture content of 4.77 ± 0.24 % and rosmarinic acid content of 0.0566 ± 0.0075 %. The HPLC method was validated; it showed good linearity, specificity, precision, and accuracy. Furthermore, the system suitability was achieved. The T. laurifolia leaf granules obtained from the optimal microwave-assisted drying condition were further used to prepare T. laurifolia leaf tablets by the wet granulation method. Three batches of 650 mg tablets containing 250 mg of T. laurifolia leaf powder were prepared using different compression forces: 500, 1,000 and 1,500 psi. The suitable compression force was 1,500 psi; the tablet formulation had suitable hardness (9.88 ± 0.52 kP), low friability (0.20 %), and a short disintegration time (23.17 ± 0.76 s). Rosmarinic acid marker was dissolved from the tablets for approximately 75 % within 4 h when 0.5 % sodium lauryl sulfate aqueous solution was used as dissolution medium. In conclusion, microwave-assisted drying could be applied in preparing T. laurifolia leaf tablets by shortening the granules drying time.
HIGHLIGHTS

The 32 full factorial design was applied to optimize microwave-assisted drying of Thunbergia laurifolia leaf granules
The optimal microwave-assisted drying condition providing the low moisture content with high rosmarinic acid content was the power of 450 W for 13 min
The tablets prepared from laurifolia leaf granules had suitable hardness, low friability, short disintegration time, and a high percentage of rosmarinic acid marker dissolved

 GRAPHICAL ABSTRACT
Magnetic Properties of Ancient Sediments Bengawan Solo, Central Java-East Java, Indonesia
Authors: Legowo Budi , Putra Shandiyano , Purwanto Heri , Rifai Hamdi , Suryanto Wiwit , Purnama Budi
Published: March 2023

Information about the eruption of Mount Lawu in Central Java Province in 1885 and Mount Merapi in D.I. Yogyakarta in 2010 became a source for estimating the presence of magnetic minerals which underwent a sedimentation process in the Bengawan Solo River from upstream (Wonogiri) - downstream (Bojonegoro). The results we get of the magnetic susceptibility distribution of the Bengawan Solo sediments reveal that the sediment from the upper reaches of the Bengawan Solo River has a low frequency magnetic susceptibility value in upstream of around 1,080.23×10−8 m3/Kg - 2,780.77×10−8 m3/Kg, the middle part is 74.40×10−8 m3/Kg - 1,735.90×10−8 m3/Kg, and downstream 17.57×10−8 m3/Kg - 1,620.53×10−8 m3/Kg. The value of magnetic susceptibility decreased significantly from upstream to downstream. High susceptibility indicates the sample contains metal elements. In determining iron oxide, we use X-Ray Fluorescence assisted by X-Ray Diffractometer testing to determine magnetic minerals. X-Ray Fluorescence confirm metal oxide in the sample. There are Al and Fe confirm the presence of magnetic properties in sedimentation. The Vibrating Sample Magnetometer confirmed that the Bengawan Solo sediment has a magnetic saturation about 0.06 - 9.50 (emu/g), a magnetic remanent around 0.001 - 0.575 (emu/g) and coercivity field of around 10 - 60.15 (Oe). X-Ray Diffractometer pattern confirm the mineral structures, namely Coesite, Magnetite, Cristobalite, Portlandite, Quartz, Anatase, Goethite, Tridymite, Gibsyte, Stishovite, Grasullaria, Labradorite and Wuestite. These results indicate the novelty of sediments from Bengawan Solo, Central Java to East Java.
HIGHLIGHTS
We found several important points in this research:

The Bengawan Solo River is formed from several formations and lifting from faults
The Bengawan Solo River is rich in minerals formed from metal oxides
The magnetic value decreases with the distance from Mount Lawu
The Bengawan Solo River has confirmed ferromagnetic properties from the S-type hysterisis curve

With low magnetic remanent values, low saturation magnetism and high magnetic corrosivity
GRAPHICAL ABSTRACT
CONHECIMENTOS NECESSÁRIOS PARA A PRÁTICA DE ORALIDADE NA ESCOLA
Authors: BARBOSA Gisele Oliveira , MAGALHÃES Tânia Guedes
Published: March 2023

Considerando a importância da oralidade para o ensino de Língua Portuguesa na escola básica e a superação da dicotomia fala/escrita, este trabalho objetiva analisar como os docentes de uma rede de municipal de educação de Minas Gerais abordam os gêneros orais na sala de aula, buscando, a partir de suas práticas, compreender quais desafios ainda residem neste trabalho. Trata-se de uma etapa que antecede outra, que se detém na construção de formas de superação dos entraves mapeados. Entre os pressupostos teóricos da investigação estão os estudos de Marcuschi (2001), Rojo e Schneuwly (2006), Galvão e Azevedo (2015), Bentes (2010), dentre outros, que se dedicam a discutir questões relacionadas ao tratamento da fala e dos gêneros orais no ensino. Com corpus constituído a partir de respostas de docentes a um questionário online, em 2019, os resultados permitiram entrever como a prática com gêneros orais ocorre, considerando 1) concepções gerais e práticas dominantes; 2) diversidade de gêneros selecionados; 3) abordagem de elementos extralinguísticos; e 4) desafios: conhecimentos necessários ao ensino de gêneros orais. Compreendemos que, investigando a prática realizada pelos docentes, podemos buscar uma futura intervenção de maior qualidade que parta do trabalho já desenvolvido para construir percursos que busquem superar as lacunas indicadas.
Prescription drug monitoring program (PDMP) utilization and outcomes within the West Palm Beach Veterans Affairs (VA) healthcare system
Authors: Schroth, PharmD, BCPS Lauren , DiScala, PharmD, BCPS Sandra , Vartan, PharmD, BCPS Christine M. , Forbes, PharmD Hiroko
Published: March 2023

Objective: Prescription drug monitoring programs (PDMPs) can identify patients at risk of controlled substance (CS) polypharmacy and accidental poisoning.Design: A retrospective pre-/post-intervention review of a random sample of provider notes with documentation of PDMP outcomes was completed before and after the enactment of a Florida law mandating PDMP queries.Setting: West Palm Beach Veterans Affairs Health Care System, which provides inpatient and outpatient services.Participants: Reviewed a random sample of 10 percent of progress notes documenting PDMP outcomes between September and November 2017 and the same timeframe of 2018.Interventions: Florida enacted a law in March 2018 requiring PDMP queries to be completed for all new and renewed CS prescriptions.Main outcome measured: The primary outcome was to compare PDMP utilization and prescribing decisions based on query results before and after the enactment of the law.Results: The number of progress notes documenting PDMP queries increased by over 350 percent from 2017 to 2018. In 2017 and 2018, 30.6 percent (68/222) and 20.8 percent (164/790) of PDMP queries found non-Veterans Affairs (VA) CS prescriptions, respectively. Providers decided to avoid prescribing CS prescriptions in 23.5 percent (16/68) of patients with non-VA CS prescriptions found in 2017 and 11 percent (18/164) in 2018. Overlapping or unsafe combinations were identified in 10 percent (7/68) of queries with non-VA prescriptions found in 2017 and 14 percent (23/164) in 2018.Conclusions: Mandating PDMP queries resulted in an increase in the total number of queries, positive findings, and overlapping CS prescriptions. Outcomes of PDMP mandate impacted prescribing by discontinuation and avoidance of CS initiation in 10-15 percent of patients.
AGENT-BASED SIMULATION FOR UNIVERSITY STUDENTS ADMISSION: MEDICAL COLLEGES IN JORDAN UNIVERSITIES
Authors: Assayed Suha Khalil , Maheshwari Piyush
Published: March 2023

Medical colleges are considered one of the most competitive schools compared to other university departments. Most countries adopted the particular application process to ensure maximum fairness between students. For example, in UK students apply through the UCAS system, and most of USA universities use either Coalition App or Common App, on the other hand, some universities use their own websites. In fact, a Unified Admission Application process is adopted in Jordan for allocating the students to the public universities. However, the universities and colleges in Jordan are evaluating the applicants by using merely the centralized system without considering the socioeconomics factor, as the high school GPA is the essential player their selection mechanism. In this paper, the authors will use an Agent Based model (ABM) to simulate different scenarios by using Netlogo software (v. 6.3). The authors used different parameters such as the family-income and the high school GPA in order to maximize the utilities of the fairness and equalities of universities admission. The model is simulated into different scenarios. For instance, students with low family income and high GPA given them the priority in studying medicine comparing with same high school GPA and higher family-income, as a results, after several rotations of the simulation the reputation of medical schools are identified based on students’ preferences and seats’ allocated as it shows that high ranking universities are mainly allocated with have high cut-off GPA score.
The association between nutritional factors and hypertension
Authors: Tung Ho Thanh , Al-Samhari Galal Abdullah , Al-Mushiki Gaber Musaed , AlRomaima Abdulbaset , Al-Shaebi Fadhl , Al-Nahari Saddam Abdulhakeem , Dinh Tran Van , Jiang Yueming
Published: March 2023

Hypertension is a growing public health issue with serious health consequences worldwide. The association between nutritional factors and hypertension have been reported in the literature. This literature review aims to investigate the association between nutritional factors and hypertension. Studies published from 1999 to 2021 in English were search using Medline, Pubmed, Scopus, Web Science, and Google Scholar databases. Keywords included hypertension, blood pressure, fats, protein, carbohydrates, sodium, fiber, potassium, calcium, magnesium, diet and literature review. The number of references included in this review was 85. This review found a significant association between hypertension and consumption of saturated fats, monounsaturated and omega-3 fatty acids, sodium, potassium, fiber, and protein. However, there are still unclear and inconsistent associations in studies on the association between carbohydrates, calcium, and magnesium with hypertension.
Eating habits and food consumption frequency of some food groups of students aged 12 - 15 years in Thuy Nguyen, Hai Phong in 2019
Authors: Tung Do Son , Thang Nguyen Duc , Phuong Duong Thi , Hanh Khuc Thi Hong , Due Ong The , Duy Hoang Bao , Toi Phung Lam
Published: March 2023

Eating habits are a critical part of life because they can affect long - term health. A descriptive cross - sectional study was conducted on 1588 students aged 12 - 15 years in Hai Phong in May 2019 with indirect interview using self - administered questionnaire with questions regard the eating habits and food consumption frequency of some food groups. There were 29.6% of students reported that they skipped at least one meal a day. Breakfast was the most frequently skipped meal. Students aged 13 and 14, with parents’ occupations such as farmers, employees, and freelancers, and those whose Z-score BMI >+1 are statistically associated with skipping meals. Fruits and vegetables were food that likely to be consumed every days. Some students still consumed alcohol. There should be communication programs for parents, students, school to understand the benefit of having a healthy diet and consuming healthy food as well.
Health risk behaviors among adolescents and related factors in Binh Dinh province in 2019
Authors: Thanh Tran Tien , Due Ong The , Khoa Nguyen Trong , Hanh Khuc Thi Hong , Duy Hoang Bao , Toi Phung Lam
Published: March 2023

To describe the prevalence of health - risk behaviors among secondary school students in Binh Dinh province, as well as the associated factors, a cross - sectional study was conducted on 2081 students aged 12 to 15 years from three secondary schools in Binh Dinh province, November 2019. The data were collected by indirect interview using a structured questionnaire. The prevalence of health - risk behaviors among secondary school students in Binh Dinh province was still high, especially consuming fatty foods (32.1%). 14 years-old and 15 years-old consumed more fatty foods and used more smart devices than 12 years-old students. Students of 15 years old consumed more soft drinks and participated in less physical activity than the 12-year-olds. Boys consumed more fast food, alcohol, soft drinks, and tobacco than girls. Additionally, girls consumed more fatty foods, used smart devices more frequently, and engaged in less physical activity than male students. Consumption of fatty meals, soft drinks, and fast food; alcohol usage; less physical activity; smoking habits and use of smart devices were discovered to be associated with age and gender of research participants. Health promotion interventions focusing on health risk behaviors related to eating and living habits should be considered.
Identification of bioactive compounds Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening
Authors: Lien Pham Thi Kim , Cho Sang Huyn , Phuong Tran Thi Van , Hung Tran Thi Mai , Anh Vu Thi Mai , Anh Dang Duc
Published: March 2023

Drug discovery and development for Mycobacterium tuberculosis (Mtb) has progressed significantly in more than 20 years, although it is still woefully underfunded. From a drug discovery perspective, tuberculosis is a particularly challenging disease. Screening for new antimicrobial agents is routinely conducted only against actively replicating bacteria. However, it is now widely accepted that a physiological state of nonreplicating persistence (NRP) is responsible for antimicrobial tolerance in many bacterial infections. The MICs of 138 established pure bioactive compounds determined in microplate cultures, of which anaerobic conditions were maintained for ten days and, for comparative purposes, aerobic conditions for seven days. Cultures exposed to drugs under anaerobic conditions followed by 28h of “recovery” under ambient oxygen produced a luminescent signal that was, for most compounds, proportional to the number of hits determined > 90% in MICs MABA was 99 (71.7%), GAS was 118 (85.5%), and MICs LORA was 7 (5.1%). As a result, aerobic and anaerobic bacteria conditions in vitro assays are prone to support a drug discovery program for tuberculosis. These potential bioactive compounds are in the drug discovery and development of anti-tubercular drugs.
NÁVRAT K TRADIČNÝM MATERIÁLOM - KONOPNÝ BETÓN
Authors: Štefunková Zuzana , Gregorová Valéria
Published: March 2023

Uvedený príspevok sa zaoberá štúdiou znovuobjaveného prírodného materiálu - konopným betónom. Názov konopný betón je v skutočnosti mätúci, nakoľko predstavuje zmes konopného pazderia, stavebného vápna a vody, ktorá neobsahuje cement ani kamenivo. Budovy postavené z konopného betónu sa vyznačujú veľmi príjemnou a zdravou vnútornou klímou, čo má dopad na zníženie nákladov na udržanie vnútornej pohody. Konopný betón je atraktívny aj pre svojpomocných staviteľov, keďževyžaduje len minimálnu technologickú vybavenosť. Pestovanie konopy siatej je nenáročné, pretože rastlina rýchlo rastie a je odolná voči škodcom. Nevýhodou je však jej zber a spracovanie, ktoré si vyžaduje špeciálnu mechanizáciu alebo ručný zber.
Kuinka hiljaisuus rikotaan: Feministisen taloustoimijuuden pragmaattinen kumouksellisuus
Authors: Lamberg Emma , Ylöstalo Hanna , Kinnunen Heini
Published: March 2023

Viime vuosina mediassa, politiikassa, kansalaisjärjestöissä ja tutkimuksessa on enenevästi esitetty feministisiä näkökulmia talouteen ja talouspolitiikkaan. Tämä artikkeli täydentää keskustelua feminismin ja talouden jännitteistä lähestyen feminististä taloustoimijuutta yhteiskunnallisena liikehdintänä, joka tarjoaa vaihtoehtoisia näkökulmia talouteen. Asiantuntijahaastatteluja analysoimalla kysymme, miten feministinen taloustoimijuus rikkoo talouden sukupuolta koskevaa strategista hiljaisuutta ja millaista kumouksellista potentiaalia sen esittämiin vaihtoehtoihin sisältyy. Tarkastelemme etenkin feminististen taloustoimijoiden näkökulmia taloutta koskevaan tietoon, talouspolitiikkaan ja talouskeskusteluun. Empiirisen analyysin pohjalta osoitamme, että toimijoiden strategioita leimaa tasapainoilu: feministisiä tavoitteita pyritään edistämään pukemalla niitä vallitsevien talousjärkeilyjen kielelle, samalla kuitenkin ajaen talouden paradigman muutosta. Esitämme, että tätä tasapainoilua voi luonnehtia pragmaattiseksi kumouksellisuudeksi, jossa käytännönläheisyys ja kumouksellisuus eivät ole vastakkaisia toiminnan tapoja, vaan pragmaattisuus näyttäytyy yhtenä reittinä kumouksellisuuteen.
Profile-based estimated inversion strength
Authors: Wang Zhenquan , Yuan Jian , Wood Robert , Chen Yifan , Tong Tiancheng
Published: March 2023

Abstract. To better measure the planetary boundary layer inversion strength (IS), a novel profile-based method of estimated inversion strength (EISp) is developed using the ERA5 daily reanalysis data. The EISp is designed to estimate the IS based on the thinnest possible reanalysis layer above the lifting condensation level encompassing the inversion layer.
At a ground-based site in North America, the EISp correlates better
with the radiosonde-detected IS (R=0.74) than the lower-tropospheric
stability (LTS, R=0.53) and the estimated inversion strength (EIS,
R=0.45). The daily variance in low cloud cover (LCC) explained by the
EISp is twice that explained by the LTS and EIS. Higher correlations
between the EISp and the radiosonde-detected IS are also found at other radiosonde stations of the subtropics and midlatitudes. Analysis of LCC observed by geostationary satellites and the Moderate Resolution Imaging Spectroradiometer shows that the EISp explains
78 % of the annual mean LCC spatial variance over global oceans and land, which is larger than that explained by the LTS and EIS (48 % and 13 %). Over tropical and subtropical low-cloud-prevailing eastern oceans, the LCC range is more resolved by the EISp (48 %) than by the LTS and EIS (37 % and 36 %). Furthermore, the
EISp explains a larger fraction (32 %) in the daily LCC variance as compared to that explained by the LTS and EIS (14 % and 16 %). The seasonal LCC variance explained by the EISp is 89 %, which is larger than that explained by the LTS and EIS (80 % and 70 %). The LCC–EISp relationship is more uniform across various timescales than the LCC–LTS and LCC–EIS relationships. It is suggested that the EISp is a better cloud-controlling factor for LCC and is likely a useful external environmental constraint for process-level studies in which there is a need to control for large-scale meteorology in order to isolate the cloud responses to aerosols on short timescales.
Estimating response times, flow velocities and roughness coefficients of Canadian Prairie basins
Authors: Shook Kevin Robert , Whitfield Paul H. , Spence Christopher , Pomeroy John Willard
Published: March 2023

Abstract. The hydrology and hydrography of the Canadian Prairies are complex and difficult to represent in hydrological models. Recent studies suggest that runoff velocities in the Canadian Prairies may be much smaller than are generally assumed. Times to peak, basin-scale flow velocities and roughnesses were derived from hourly streamflow hydrographs from 23 basins in the central Alberta Prairies. The estimated velocities were much smaller than would be estimated from most commonly used empirical equations suggesting that many existing methods are not suitable for estimating time to peak or lag times in these basins. Basin area was found to be a poor predictor of basin-scale rainfall-runoff flow velocity. Estimated velocities generally increased with basin scale, indicating that slow basin response at small scales could be related to predominance of overland and/or shallow subsurface flow over the very level topography. Basin-scale Manning’s roughness parameters, commonly used in hydrological models, were found to be orders of magnitude greater than values commonly used for streams in other parts of the world. The very large values of roughness call into question whether the Manning equation should be used for modelling runoff on the Prairies. These results have important implications for modelling rainfall-runoff in this region since using widely published values of roughness will result in poor model performance. It is likely that the Darcy-Weisbach equation, which is applicable to all flow regimes, may perform better in hydrological models of this region. Further modelling and field research will be required to determine the physical causes of these very small basin-scale velocities.
A versatile end effector for grabbing and spreading of flaky deformable object manipulation
Authors: Huan Yuan , Ren Gongchang , Su Xiangyu , Tian Weizhi
Published: March 2023

Abstract. It is a conundrum to use robots to complete the intelligent operation of leather and clothing fabrics; this is mainly reflected in the design of an end effector that can realize this function. We have determined the design requirements and objectives of the end effector by observing the action of manually grabbing and spreading leather, and put forward an end effector composed of a reconfigurable multi-link mechanism and roller-type fingertip, which can be used to grab and spread flaky deformable object manipulation. At the same time, the reconfigurable multi-link mechanism and roller-type fingertip are introduced and analyzed in detail. By setting up the prototype of the end effector and completing the grabbing experiment of three kinds of soft pieces, we verified and tested the rationality of the prototype design. The result shows that the grabbing success rate will be affected by many factors, and further exploration is needed to further improve the performance of the end effector.
Giant mid-Holocene landslide-generated tsunamis recorded in lake sediments from Saqqaq, West Greenland
Authors: Korsgaard Niels J. , Svennevig Kristian , Søndergaard Anne S. , Luetzenburg Gregor , Oksman Mimmi , Larsen Nicolaj K.
Published: March 2023

Abstract. The Vaigat strait (Sullorsuaq) in central West Greenland is well known for its susceptibility to landslides and historical landslide-generated tsunamis. Recent mapping of the seabed in the Vaigat Strait has revealed several prehistoric giga-scale tsunamigenic landslides; however, their ages are unknown. Here, we report sedimentological evidence from six coastal lakes at 19 to 134 m above sea level (a.s.l.) on the Saqqaq foreland located at the eastern end of Vaigat. Using optical, X-ray fluorescence (XRF), and magnetic susceptibility core scanning in our sedimentological analysis along with a screening for marine diatoms and radiocarbon dating, we find evidence of at least two tsunami events occurring at 7.6 and 7.3 cal. ka BP. Using a previously published, recalibrated relative sea level curve from Arveprinsen Ejland (Alluttoq), located 40 km southeast of Saqqaq, we infer wave run-up heights of 41–66 and 45–70 m respectively for the two tsunamis. These run-up heights from prehistoric tsunamis are several orders of magnitude larger than the historic landslide-tsunami run-up heights at Saqqaq which only reached an elevation of c. 3 m in November 2000. While two giant tsunamis can be found in the lake sediment records, landforms from at least nine giga-scale landslides are present on the seafloor of Vaigat, we infer that the older giant tsunamis must have happened between the last deglaciation and the oldest sediment in the lakes (c. 10 to 8.5 cal. ka BP).
Impact of topography on in situ soil wetness measurements for regional landslide early warning – a case study from the Swiss Alpine Foreland
Authors: Wicki Adrian , Lehmann Peter , Hauck Christian , Stähli Manfred
Published: March 2023

Abstract. Recent studies have demonstrated the potential of in situ
soil wetness measurements to predict regional shallow landslides. Increasing
availability of monitoring data from sensor networks provides valuable
information for developing future regional landslide early warning systems
(LEWSs); however, most existing monitoring sites are located on flat
terrain. The question arises of if the representativeness for regional
landslide activity would improve if sensors were installed on a
landslide-prone hillslope. To address this, two soil wetness monitoring
stations were installed at close proximity on a steep slope and on a flat
location in the Napf region (Northern Alpine Foreland of Switzerland), and
measurements were conducted over a period of 3 years. As both sites inhibit
similar lithological, vegetation, and precipitation characteristics, soil
hydrological differences can be attributed to the impact of topography and
hydrogeology. At the sloped site, conditions were generally wetter and less
variable in time, and evidence was found for temporary lateral water
transport along the slope. These differences were systematic and could be
reduced by considering relative soil moisture changes. The application of a
statistical landslide forecast model showed that both sites were equally
able to distinguish critical from non-critical conditions for landslide
triggering, which demonstrates the value of existing monitoring sites in
flat areas for the application in LEWSs.
Investigation of Dielectric, Magnetic and Electrical Behavior of BFO/GNPs Nano-Composites Synthesized via Sol-Gel Method
Authors: Nageena Arsa , Manzoor Alina , Muhammad Afzal Amir , Arshad Muhammad Imran , Shahzad Aamir , Kashif Muhammad
Published: March 2023

Nano composites of Ba0.5Bi0.5Nd0.05Fe0.95O3 multiferroic with graphene nano platelets (GNPs)x (x = 0, 0.125 %, 0.375 %, and  0.5 %) were synthesized using sol-gel auto ignition process. XRD analysis revealed a single rhombohedrally distorted phase of Ba0.5Bi0.5Nd0.05Fe0.95O3. The present study unfold the impact of GNPs on the structural, electrical, dielectric, and magnetic properties of Ba0.5Bi0.5Nd0.05Fe0.95O3 multiferroics. The substitution of Rare earth elements in pure BFO reduced the value of leakage current which is the basic drawback related with pure BFO. The prepared nanocomposites are then sintered at 800 °C for 7 hrs. The X-ray diffraction patterns showed the rhombohedral distorted perovskite crystal structure of the prepared samples including lattice constant, crystallite size, and X-ray density. The average crystallite sizes of the prepared nanocomposites are noticed in the range 28.14 -to 29.74 nm with increasing the GNPs concentration and lattice constant is found in the range 11.59 -to 11.61 Å. Temperature-dependent resistivity is first observed to increase with an increase in temperature then resistivity decreased with increasing the temperature which indicates a semi-conductor-like behavior as measured by two probe I-V characteristics. LCR technique showed that both the dielectric constant and the dissipation factor are decreased with an increase in frequency. VSM results indicated that saturation magnetization is noted to increase while remanent magnetization decreases with increasing concentration of GNPs.
PENGARUH ROLE STRESS, EMOTIONAL INTELLIGENCE, DAN ASPEK PSYCHOLOGICAL WELL-BEING TERHADAP KINERJA AUDITOR
Authors: Prasetyo Hendi , Zulaika Tatik , Marsenn Maureen
Published: March 2023

The purpose of this study was to examine Role Stress, Emotional Intelligence, and Psychological Well-Being Aspects on Auditor Performance at BPK KalTeng. The data used in this study are primary data. Respondents in this study were 68 employees. The method of collecting data in this study using a questionnaire. This research shows that Role Stress, Emotional Intelligence, and Psychological Well-Being Aspects have an effect on Auditor Performance.
ROLE OF TUMOR NECROSIS FACTOR-?ETA (TNF-?) IN GASTRIC CANCER: SINGLE NUCLEOTIDE POLYMORPHISMS ANALYSIS-AN IN-SILICO STUDY
Authors: Bilal Asif , Ahmad Sibtain , Nisa Fakhr Un , Ali Furqan , Ramzan Kainat , Tariq Muhammad , Saleem Muhammad
Published: March 2023

Tumor necrosis factor-beta is also called lymphotoxin-alpha. The objective of this study was to identify non-synonymous SNPs of TNF-beta and their association with gastric cancer using computational analysis. For this purpose, different online tools like SIFT, Polyphen, Polyphen-2, fuNTRp, SNAP2 (to identify pathogenic SNPs), SNP&GO, PhD-SNP, PredictSNP, MAPP, SNAP, MetaSNP, PANTHER (disease associated SNPs), Mu-Pro, I-Mutant, and CONSURF (to check protein stability) were used. Post-translational modifications (PTMs) were detected by Musitedeep, Protein secondary structure by SOPMA, and Protein to protein interaction by STRING. Three SNPs having rsIDs (rs1325992410, rs1290487566, and rs769344065) showing mutations on Y110C, G117E, and G170R, respectively found to be completely deleterious. The PTMs found were phosphorylation at amino acid number 2 and 128; palmitoylation at number 13; pyrrolidone carboxylic acid at number 33 and glycosylation at number 41 and 46. The protein secondary structure consisted of alpha helix (18.54%), extended strand (29.27%), beta turn as 6.83% and random coil (45.37%). Protein-protein interaction analyses revealed that it has strong interaction with Mitogen Activated Protein (MAP) kinase (MAP3K14). Based on these results, it is concluded that these three SNPs found in TNF-B are involved in gastric cancer.
PREVALENCE OF PULMONARY AND EXTRA PULMONARY TUBERCULOSIS IN PUNJAB POPULATION OF PAKISTAN
Authors: Khurram Muhammad , Mateen Rana Muhammad , Murtaza Ghulam , Fareed Muhammad Irfan , Ali Muhammad , Tipu Imran , Afzal Muhammad Sohail , Parveen Rukhsana , Hussain Mureed
Published: March 2023

Tuberculosis, being one of the top 10 death causing diseases worldwide, is still widespread in developing countries. Pakistan is currently ranked fifth among the high tuberculosis burden countries and 5 % of the total patients worldwide are from this country. The study was conducted on 633 tuberculosis patients involving both pulmonary and extrapulmonary tuberculosis from Punjab population of Pakistan. Male to female ratio was found to be 0.96 in this population. Most of the individuals infected from this disease were found to be of age group 15-34 where 38.38% males and 46.43% females were infected. Among pulmonary tuberculosis, age group <15 was most infected with 31.11% males and 39.84% females while among extra pulmonary tuberculosis age group 15-34 was found most infected with 51.53% males and 56.31% females. Significant difference in MFR and age groups prevalence of this disease was noted when compares with neighbor countries India and Iran.
The impact of occupational exposures on infection rates during the COVID-19 pandemic: a test-negative design study with register data of 207 034 Dutch workers
Authors: Eekhout Iris , van Tongeren Martie , Pearce Neil , Oude Hengel Karen M
Published: March 2023

OBJECTIVE: This study aimed to investigate the effects of occupational exposures on the risk of a positive COVID-19 test, and whether this differed across pandemic waves.

METHODS: Data from 207 034 workers from The Netherlands with test data on COVID-19 from June 2020 until August 2021 were available. Occupational exposure was estimated by using the eight dimensions of a COVID-19 job exposure matrix (JEM). Personal characteristics, household composition and residence area were derived from Statistics Netherlands. A test-negative design was applied in which the risk of a positive test was analyzed in a conditional logit model.

RESULTS: All eight dimensions of occupational exposure included in the JEM increased the odds of a positive test for the entire study period and three pandemic waves [OR ranging from 1.09, (95% confidence interval (CI) 1.02–1.17) to 1.77 (95% CI 1.61–1.96)]. Adjusting for a previous positive test and other covariates strongly reduced the odds to be infected, but most dimensions remained at elevated risk. Fully adjusted models showed that contaminated work spaces and face covering were mostly relevant in the first two pandemic waves, whereas income insecurity showed higher odds in the third wave. Several occupations have a higher predicted value for a positive COVID-19 test, with variation over time.

Discussion Occupational exposures are associated with a higher risk of a positive test, but variations over time exist in occupations with the highest risks. These findings provide insights for interventions among workers for future pandemic waves of COVID-19 or other respiratory epidemics.
Beyond Sentiment Analysis: Developing Effective Methods for Specific Emotion Analysis in Marketing Using Machine Learning and Big Data
Authors: Lee Sanghyub John
Published: March 2023

The rise of social networking services has led to a significant increase in user-generated content and electronic word-of-mouth, prompting marketing researchers to focus on sentiment analysis. However, the traditional approach of categorizing emotions as positive or negative has its limitations. Our papers propose an interdisciplinary approach that uses machine learning algorithms and big data to overcome these limitations and detect specific emotions. The thesis presents four papers that go beyond the traditional sentiment analysis, using ML algorithms to analyze large amounts of online text and detect specific emotions. The results show that this approach is effective in predicting customer behavior and attitudes, such as finding relationships between brands, predicting donation behavior, and analyzing social phenomena. Four papers contribute to both marketing and engineering knowledge, as it proposes a more effective approach to specific emotion analysis that goes beyond the traditional positive/negative sentiment analysis. It also uses state-of-the-art ML algorithms to automate the detection of specific emotions in large amounts of online text. Overall, this thesis will provide insights for marketers to understand their customers' emotions and motivations more effectively, enabling them to develop more targeted and effective marketing strategies to drive engagement and conversions.
Determination of Embryotoxic effects of Atipamezole using in ovo model
Authors: Canbar Rahmi , Uslu Muhittin , Arslan Mustafa Sedat , Kızılay Harun
Published: March 2023

Atipamezole is a specific α2-adrenergic receptor antagonist, and there exists insufficient information on its use during pregnancy. The aim of this study was to determine the embryotoxic activity of Atipamezole through an in ovo method. During the first stage of the study, 210 fertile eggs were divided into seven groups of 30 fertile eggs and placed in an incubator. On the seventh day of the first stage, no application was made to the control group. The second group was administered 50 microliters (µL) of saline solution, while the other groups were given Atipamezole at doses of 250, 125, 62.5, 31.25 and 15.62 micrograms·egg-1 (µg·egg-1) in 50 µL saline solution. In the second stage, according to the embryotoxic dose range determined from the first stage, 150 fertile eggs were divided into five groups of 30 fertile eggs and placed in an incubator. On the seventh day of the second stage, no application was made to the control group. Fifty µL of saline solution was administered to the second group. The other groups were given Atipamezole at doses of 220, 190 and 160 µg·egg-1 in 50 µL saline solution. After the incubation period, the eggs hatched, and the embryonic mortality rates were calculated. The mortality rate was determined to be 39.3% at the highest dose (250 µg·egg-1 = 5 miligrams·kilograms-1 –mg·kg-1–) (P<0.05), while the mortality rate at other doses was determined to be the same as the control group (P>0.05). In conclusion, it can be stated that the dose determined for Atipamezole in this study was very high compared to the recommended doses and it can be used in pregnancy as a benefit-loss calculation when necessary. However molecular or histopathological studies regarding the development of organ drafts are necessary to determine the safety of its use during pregnancy.
Diversification Strategy and Profitability of Selected Food and Beverage Firms in Lagos State, Nigeria
Authors:   Babcock University, Ilishan-Remo, Ogun State, Nigeria, Okegbemiro S.A.
Published: March 2023

The rapid pace of competition in today’s global business environment had prompted the need for the Food and Beverage (F&B) firms around the world to produce strategies on how best to improve performance through the provision of product varieties and the need for expansion through an increase in market share, productivity, and full utilization of resources at their disposal. Despite this awareness, a persistent decline was observed in the organizational in terms of profitability and their performance outlook remained poor. The study, therefore, examined the effects of diversification strategy on the profitability of selected F&B firms in Lagos State, Nigeria. Therefore, this study examined the effect of diversification strategy and profitability of selected food and beverage firms in Lagos State, Nigeria. The study adopted a survey design, the population is given as 12, 495 regular employees of six selected F&B firms in Lagos State, Nigeria. The research advisor sampling table was used to select a sample size of 491 from the population while data was collected using a valid and reliable questionnaire with a Cronbach alpha value greater than 0.7. The data were analyzed using descriptive and inferential tools. Multiple Regression Analysis was used to determine the impact of the variables using the Statistical Package for Science Solutions (SPSS) version 24. Diversification has a significant effect on profitability (β = 0.947, t = 47.805, R2 = 0.839, p-value = 0.001). The study concludes that diversification has a significant effect on profitability of selected Food and Beverage (F&B) firms in Lagos State, Nigeria. Thus, the study recommends that Food and Beverage firms can also explore new distribution channels, invest in marketing and branding, and enhance their operational efficiency to achieve better profitability. It's also essential for them to keep track of the latest market trends and consumer preferences to develop products and services that meet the evolving needs of their customers. Keywords: Competitive Advantage, Diversification, Food and Beverage Companies, Performance Outlook, and Profitability
Pelatihan Canva untuk Mendukung Presentasi Karyawan Institut Teknologi Kalimantan
Authors: Prabowo I Putu Deny Arthawan Sugih , Purba Arini Anestesia , Anwar Putri Gesan Prabawa , Hijriah Hijriah , Lestari Rizka , Yuniar Rizka Ayu
Published: March 2023

Keterampilan presentasi karyawan ialah penting dimiliki oleh setiap karyawan di perusahaan atau instansi manapun, termasuk para tenaga kependidikan (staf) di Institut Teknologi Kalimantan (ITK). Keterampilan presentasi karyawan merupakan suatu kebutuhan penting dalam meningkatkan kinerja karyawan dari setiap divisi atau bagian organisasi (perusahaan atau instansi). Presentasi digunakan untuk memberi rangkuman dari setiap aktivitas bisnis organisasi. Salah satu aplikasi yang digunakan untuk membuat materi dan menyajikan materi presentasi yang menarik ialah Canva. Canva merupakan aplikasi yang sangat diminati oleh kalangan praktisi atau karyawan dengan fitur yang terdiri dari berbagai template menarik sehingga hal ini dapat meningkatkan daya tarik para penyimak pada presentasi yang disampaikan oleh penyaji tersebut. Karyawan di Institut Teknologi Kalimantan hanya sekitar 30% yang dapat menggunakan aplikasi Canva. Hal ini yang menjadi dasar kegiatan pengabdian masyarakat berupa peningkatan kompetensi penggunaan Canva untuk mendukung presentasi karyawan. Metode Pelatihan ini dilakukan dengan beberapa tahapan Persiapan, Pelaksanaan, dan Evaluasi Kompetensi. Hasil dari pelatihan ini dapat meningkatkan kompetensi Karyawan Institut Teknologi Kalimantan menjadi 80%.
Pelatihan Pembuatan Pasta Gigi Herbal dari Cangkang Telur Ayam dan Ekstrak Daun Sirih di Desa Burai Kecamatan Tanjung Batu Kabupaten Ogan Ilir
Authors: Hariani Poedji Loekitowati , Fatma Fatma , Said Muhammad , Rohendi Dedi , Mohadi Risfidian
Published: March 2023

Penggunaan pasta gigi herbal dapat mengurangi terbentuknya plak pada gigi. Pasta gigi herbal memiliki kelebihan yaitu murah, pembuatan mudah dan aman. Kegiatan pengabdian pada masyarakat yang dilaksanakan di desa Burai, kecamatan Tanjung Batu, Ogan Ilir bertujuan untuk memberikan pelatihan dan pendampingan pembuatan pasta gigi herbal dengan bahan utama cangkang telur ayam dan ekstrak daun sirih. Peserta kegiatan adalah ibu-ibu dan remaja putri sebanyak 30 orang. Metode kegiatan berupa penyuluhan tentang pentingnya menjaga kebersihan mulut dan gigi, cara pembuatan pasta gigi herbal, pendampingan membuat pasta gigi herbal dan evaluasi hasil. Produk pasta gigi yang dihasilkan memiliki pH rata-rata 7.2, memenuhi baku mutu SNI yaitu 4,5-10. Hasil evaluasi kegiatan pengabdian masyarakat menunjukkan terjadinya peningkatan pengetahuan masyarakat tentang pasta gigi herbal. Berdasarkan hasil evaluasi juga diketahui bahwa persentase rata-rata jawaban tepat kuisoner sebelum penyuluhan sebesar 15 %, sesudah pelatihan meningkat menjadi 91,1 %. Hasil analisis tingkat kesukaan terhadap produk pasta gigi herbal menunjukkan bahwa lebih dari 80 % peserta kegiatan menyatakan sangat suka terhadap aroma, warna, bentuk dan kenyamanan pasta gigi ketika digunakan. Masyarakat memiliki minat yang tinggi untuk membuat pasta gigi herbal setelah kegiatan pelatihan.
Strategi Pemasaran dan Penjualan dengan Pendekatan Analisa SWOT pada Produk Usaha Leche
Authors: Fatchurrohman Mochamad , Sukatmadiredja Noneng R , Wibowo Bambang Sri , Desiane Ajeng Nurwinda
Published: March 2023

Leche merupakan salah satu usaha minuman yang berbahan dasar susu di Surabaya yang cukup banyak diminati oleh berbagai kalangan masyarakat. Tujuan dilakukannya penelitian ini adalah untuk mengetahui dan menganalisa strategi pemasaran dan penjualan yang digunakan dalam produk usaha leche. Metode yang digunakan pada penelitian ini yaitu metode analisis kualitatif deskriptif menggunakan analisis SWOT. Teknik pengambilan data yang digunakan dalam penelitian ini yaitu dengan cara observasi dan studi pustaka. Hasil penelitian dari analisis SWOT pada usaha “Leche” menunjukan bahwa usaha ini berada pada kuadran III, dimana hal ini menggambarkan bahwa posisi usaha berada pada kondisi yang memiliki kekuatan internal lemah. Sehingga, para produsen dari udaha tersebut harus melakukan upaya untuk memberikan peluang lebih dan mendapatkan peluang yang lebih baik lagi di pasar dagang. Oleh karena itu, strategi yang harus digunakan Leche yaitu melalui strategi marketing mix strategi dengan mengupayakan antara produk, price, dan juga promotion berjalan dengan baik sehingga konsumen dapat menerima informasi dengan jelas dan mempermudah mereka untuk melakukan pemesanan dengan baik.
Game Edukasi Pengenalan Tokoh Pewayangan untuk Kelas 4 di Sekolah Dasar Negeri 1 Polan
Authors: Irsyadi Fatah Yasin Al , Narendra Majid , Kurniawan Yogiek Indra
Published: March 2023

Metode belajar manual sering kali membuat siswa mudah bosan dan tidak memperhatikan apa yang disampaikan oleh guru. Hal ini membuat siswa malas untuk belajar.Game edukasi dapat menjadi media pembelajaran alternative untuk mengembalikan minat belajar siswa. Pengunaan game edukasi dalam pendidikan dan pengajaran terus bertambah. Hal ini karena game edukasi memiliki kelebihan dalam hal visualisasi dari kasus nyata. Tidak hanya itu game edukasi pula mempunyai bentuk pengajaran yang cepat, menarik serta bermanfaat. Game edukasi pengenalan tokoh pewayangan ini menggunakan metode GDLC. Penelitian ini bertujuan untuk mengenalkan kepada siswa tokoh wayang yang ada di Indonesia dengan cara yang menyenangkan dan tidak membuat siswa bosan dengan adanya animasi yang menarik. Game ini dibuat menggunakan software Construct 2. Pengujian game ini menggunakan black box testing dan paired sample t-test dengan responden yang terdiri dari 30 orang. Berdasarkan pengujian yang dilakukan memperolah hasil t-hitung > t-tabel sebesar 4.334 > 2.045 sehingga kesimpulannya memiliki pengaruh dalam meningkatan minat belajar siswa sehingga game wayang ini layak diterapkan sebagai media pembelajaran.
Potentials of Polymeric Nanocarriers Loaded with Clarithromycin for Antibacterial Activity
Authors:   Department of Pharmacy, Hygia College of Pharmacy, Dr. A. P. J. Abdul Kalam Technical University, Lucknow. (Utter Pradesh), India, Misra Shivendra , Prajapati Vivekanand ,   Department of Pharmacy, Hygia College of Pharmacy, Dr. A. P. J. Abdul Kalam Technical University, Lucknow. (Utter Pradesh), India, Mishra Dr. N T Pramathesh ,   Department of Pharmacy, Hygia College of Pharmacy, Dr. A. P. J. Abdul Kalam Technical University, Lucknow. (Utter Pradesh), India
Published: March 2023

Clarithromycin (CTM) is a semisynthetic derivative of erythromycin that have been reported to exhibit potential antibiotic activities mostly against the gram-negative and gram-positive bacteria, lower/upper respiratory tract and skin infection causing pathogens. It is widely used for the prevention and management of infections due to Mycobacterium avium complexes and peptic ulcers due to Helicobacter pylori. Various marketed formulation of CTM in the form of tablets, capsules and other conventional dosage forms is available as anti-infective, however the drug itself has several limitations. These limitations include low oral bioavailability, rapid metabolism, poor targeting to infected sites and toxicity to normal cells/tissues. Also, the CTM-based therapy has been reported for several gastrointestinal adverse effects, including diarrhea, stomach upset, gastric distress, atypical taste, and others. Thus, to overcome these issue, various novel strategies including nanotechnology or nanocarrier-based approaches have showed significant effects and have been immensely considered worldwide. In recent years, the various nanocarriers or nanocarrier-based delivery systems, particularly the polymeric nanocarrier have played significant role in effective drug targeting. Thus, in this review, the various polymeric nanocarrier-based delivery systems of CTM that effective reduced the dosing frequency, improved the patient compliance and potentially enhanced the therapeutic efficiency of CTM has been summarized.
A Study of the Movement of a Neutrosophic Material Point in the Neutrosophic Plane by Using a Neutrosophic AH-Isometry
Authors:   Departement of  Mathematics, Albaath University,Homs, Syria, Alhasan Mountajab ,   Departement of  Mathematics, Albaath University,Homs, Syria, Alaswad Malath F
Published: March 2023

This articles presents a new concept in mathematics according to a neutrosophic logic, which is the first of its kind in applied mathematics, which is the concept of the movement of a neutrosophic point in the neutrosophic plane and determining the path of this point, after determining Cartesian and polar neutrosophic coordinates of this point and also defining the neutrosophic local, velocity and acceleration vectors of these point. We have also determined the relationsships between the motion of a neutrosophic point and its equivalent in the classical plane, through an AH-isometry that connects the neutrosophic and classical plane. We conducted the previous study on three different examples, each example differs from the other in the form of a path and type of movement of the studied point.