bluuebunny/crossref_metadata_2025 huggingface dataset:
Démarche et processus des États généraux du travail social
Authors: Bouquet Brigitte , Jaeger Marcel
Published: March 2016

Lancés en 2013 par le gouvernement, les États généraux du travail social avaient pour objectif de reconnaître et soutenir le travail social comme acteur des politiques publiques de cohésion sociale, de redonner du sens à ses actions, de faire évoluer le regard porté sur le travail social par la société, de faire partager le plus largement possible une vision ambitieuse du travail social pour le xxi e  siècle. Cet article rappelle la démarche et le processus menés jusqu’à la présentation en conseil des ministres du Plan d’action en faveur du travail social et du développement social.
Les dynamiques repérées lors des assises interrégionales
Authors: Bouquet Brigitte , Crespo Geneviève
Published: March 2016

Les travaux préparatoires aux Assises et les assises territoriales interrégionales ont été une contribution importante aux États généraux du travail social. Les différents acteurs (publics, associations, travailleurs sociaux...) y ont procédé à l’élaboration de diagnostics sur les difficultés et les points forts du travail social, à l’identification de pratiques « innovantes », à l’élaboration de propositions pour les États généraux. Malgré l’implication différente selon les interrégions, ils ont apporté de nombreuses réflexions sur l’adéquation entre les pratiques de travail social, les attentes des usagers et les problématiques sociales actuelles. Cet article en rend compte de façon synthétique.
Droits des personnes accompagnées. Responsabilités et nouvelles pratiques
Authors: Papay Jacques
Published: March 2016

La mise en œuvre effective de l’exercice des droits des personnes accompagnées modifie en profondeur les pratiques professionnelles. En effet, la recherche constante de la participation des personnes à l’élaboration et à la conduite des activités et prestations dont elles sont bénéficiaires introduit des interactions nouvelles pouvant mettre en tension, d’une part, l’évaluation faite par la personne concernée ou par ses représentants, d’autre part, l’évaluation réalisée par les professionnels. Afin de prendre en compte ces données dans la perspective de l’effectivité de l’exercice des droits, une attention renforcée doit être portée sur le moment de l’accueil et sur le contenu du contrat.
La question de la formation aux mains des acteurs des États généraux du travail social
Authors: Lechaux Patrick
Published: March 2016

Cet article retrace le cheminement de la question de la formation au cours des egts , examinant comment les acteurs mobilisés s’en sont emparés dans leurs préconisations. Il montre, à partir d’une mise à plat de ce travail de la formation, comment on est passé d’une attente relativement consensuelle de modernisation douce du système des formations sociales à une annonce gouvernementale de refondation du modèle de la formation, même si celle-ci laisse dans l’ombre certaines questions majeures, comme la structuration de l’appareil de formation.
La formation continue, « nourriture terrestre » du travail social ?
Authors: Casagrande Alice
Published: March 2016

La formation professionnelle continue des travailleurs sociaux engage trois dimensions de l’action, à une échelle individuelle, collective et sociétale. Elle s’inscrit dans un contexte profondément rénové à la suite de la loi de mars 2014 et doit donc faire face à la fois à la raréfaction des ressources et à la responsabilisation nouvelle des acteurs. Dans ce contexte, trois pistes sont proposées pour répondre correctement aux enjeux actuels. Premièrement, faire de la formation continue un espace de maturation collective des pratiques dans un contexte où les pratiques individuelles et individualisées font figure de modèle dominant. Deuxièmement, faire de la formation professionnelle le moyen privilégié de faire naître ou d’entretenir une culture partagée sur un territoire, désormais espace-clé des accompagnements forcément pluriels. Troisièmement, investir la formation professionnelle continue comme un espace partagé pour les savoirs professionnels et les savoirs expérientiels des personnes accompagnées.
Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study
Authors: Nakakita Y. , Tsuchimoto N. , Takata Y. , Nakamura T.
Published: March 2016

We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep rhythms in mice. The present study evaluated the effect of consumption of heat-killed SBC8803 on sleep architecture in humans. A non-randomised, placebo-controlled, double blind, and crossover pilot study was conducted using volunteers who scored at a slightly high level (i.e. ≥6) on the Athens Insomnia Scale (AIS). Male subjects (n=17; age 41-69 y) consumed placebo or SBC8803 capsules (25 mg/day of heat-killed SBC8803) for 10 days. Electroencephalograms (EEG) were recorded using a mobile, one-channel system, providing objective data on sleep. Subjects’ sleep journals and administration of the AIS provided subjective data on sleep. Three subjects were excluded from the statistical analysis. Analysis of the remaining 14 volunteers revealed no significant differences between placebo and SBC8803 consumption in either the AIS or the sleep EEG. The sleep journals revealed an improvement in ‘waking’ for the SBC8803 consumption periods (P=0.047), and there was a marginally significant effect on ‘drowsiness during the following day’ (P=0.067). Effects on the EEG delta power value (μV2/min) were revealed by a stratified analysis based on age, AIS, and the Beck Depression Inventory (BDI). Specifically, effects were found among subjects in their 40s who consumed the SBC8803 capsules (P=0.049) and among subjects with a BDI score less than the all-subjects average (13.3) (P=0.045). A marginally significant effect was found among subjects with an AIS score less than the all-subjects average (11.6) (P=0.065). The delta power value of 5 subjects with both BDI and AIS scores less than the average increased significantly (P=0.017). While the number of subjects was limited, a beneficial effect on sleep due to consumption of heat-killed L. brevis SBC8803 was found in subjects with slightly challenged sleep.
An examination of jump kinematics in dogs over increasing hurdle heights
Authors: Birch E. , Carter A. , Boyd J.
Published: March 2016

Research examining kinematic parameters of the canine athlete is markedly behind equivalent human and equine research. With increasing participation and popularity, canine sports science needs to bridge this gap with comparable equine research. The aim of this study was to examine changes to specific kinematic parameters as hurdle height increases. Twenty border collies and border collie crosses were analysed jumping over a single hurdle at increasing heights, starting with a pole on the floor and increasing to a maximum height of 65 cm. Length of trajectory and jump speed were analysed, alongside apparent (without the use of markers) neck, lumbar spine and shoulder angles using Dartfish software. For each dog, the percentage of the hurdle height in relation to their height at the dorsal aspect of the scapula (withers) was used to normalise the dogs evenly. Overall jump speed decreased as percentage height increased (P<0.001), with a strong negative correlation between the two (r=-0.815). Length of trajectory significantly increased with percentage height (P<0.001) with a strong positive correlation between the two (r=0.740). However, length of trajectory decreased when a dog jumped ≥126% of its height to the withers. This is supported by a significantly more flexed apparent neck angle upon landing at this percentage height (P<0.001). Apparent lumbar spine angles showed greater dorsal extension upon landing as percentage height increased (P<0.001). Apparent shoulder angles become significantly more flexed as percentage height increased during the suspension phase of the jump (P<0.001). These results suggest that dogs significantly alter their jump kinematics as hurdle height increases.
A preliminary approach to phonological phrase in Spanish
Authors: Polo Cano Nuria
Published: March 2016

Although the prosodic hierarchy has been well established in phonological theory for decades, little empirical work on its higher constituents has been done on Spanish. This study examines two well-known phonological processes in Spanish (spirantization of voiced plosives and fricative sibilant voicing in coda position) as possible parameters in the delimitation of phonological phrases.

The data analyzed have been gathered from two native Spanish speakers from the Central Peninsular variety of Spanish, who read 334 stimuli created for that purpose.

The results suggest that there is a phonological phrase boundary between the subject and the verb, especially in long subjects. Other syntactic structures seem to be mapped as prosodic constituents of lower or higher levels (prosodic words and intonational phrases, respectively).
Design and Implementation of an Industrial Wireless Sensor Network for Temperature Monitoring
Authors: Hou Liqun , Yang Lei
Published: March 2016

Temperature signal is one of the key parameters in industrial processes. Accurate and effective temperature monitoring may provide necessary device information to the operator and prevent unexpected catastrophic equipment faults due to device overheat. Compared with wired monitoring system, wireless sensor networks (WSNs) monitoring system has many advantages, such as low cost and convenient installation. This paper proposes and implements a multichannel temperature monitoring system based on WSNs module, Jennic JN5139. The hardware circuit design of the sensor node and the software design for WSNs nodes and the centralized computer using C language and LabVIEW respectively are given in detailed. An optimization subsection algorithm based on least square for thermocouple nonlinear calibration is also explored to increase the measurement accuracy. The prototype system is evaluated with an electric furnace temperature monitoring system. The experimental results show the feasibility and effectiveness of the proposed system.
Game Theory Based Location Smoothing in Wireless Sensor Networks
Authors: Yongqiang He , Qin Qin , Wang Jun-peng
Published: March 2016

Abstract: Location estimation of mobile target is an important research in wireless sensor networks. However, the phenomenon of non line of sight affects the accuracy of location estimating algorithms greatly. In order to improve the accuracy of location estimation of mobile targets, we proposed a game theory based location method algorithm in wireless sensor networks. In the proposed method, we first estimate the initial locations of mobile target with a support vector regression model, and then use game theory to smooth the already estimated locations. In the game model, game based filter and noise generator are two game rivals. The game filter aims to minimize the objective function of the game model, and the noise generator aims to maximize the same objective function. We propose a differential game theory based algorithm for solving the optimal resolution. The experiments show that, the proposed method is more powerful, and can be used to mobile target locating and tracking.
Fault Diagnosis for Methane Sensors using Generalized Regression Neural Network
Authors: Huang Kaifeng , Liu Zegong , Huang Dan
Published: March 2016

To identify the hang, collision and drift faults of methane sensors, this paper presents a fault diagnosis method for methane sensors using multi-sensor information fusion. A methane concentration monitoring approximation model with multi-sensor information fusion is established based on generalized regression neural network (GRNN).The output of the neural network is compared with the measured value of the sensor to be diagnosed to obtain the variation curve of the residual error signal. Through the analysis of the variation tendency of the residual error signal, the fault status of a methane sensor could be determined based on a reasonable threshold. Through simulation comparison is applied between the two models of GRNN and BP neural network; verify the GRNN model is much more precise in the approximation of methane concentrations. Fault diagnosis for methane sensors using generalized regression neural network is effective and more efficient.
An Entertaining Game-Like Learning Environment in a Virtual World for Education
Authors: Han Hsiao-Cheng (Sandrine) , Zhang Junsong , Peikazadi Nasim , Shi Ge , Hung Annie , Doan Colette P. L. , Filippelli Sandra
Published: March 2016

This chapter explores the possibilities, benefits, and difficulties of developing game-like virtual environments for education. The goal of this paper is to review the background of game-like environment and impact of game-like environment on learning, discuss the differences on teacher-free and teacher-leading virtual learning environment, and provide examples of game-like environment in the virtual world for education. Finally, this chapter also provides suggestions to readers who would like to create game-like virtual environments for education.
Metabolic Reprogramming of Host Cells by Virulent Francisella tularensis for Optimal Replication and Modulation of Inflammation
Authors: Wyatt Elliott V. , Diaz Karina , Griffin Amanda J. , Rasmussen Jed A. , Crane Deborah D. , Jones Bradley D. , Bosio Catharine M.
Published: March 2016

A shift in macrophage metabolism from oxidative phosphorylation to aerobic glycolysis is a requirement for activation to effectively combat invading pathogens. Francisella tularensis is a facultative intracellular bacterium that causes an acute, fatal disease called tularemia. Its primary mechanism of virulence is its ability to evade and suppress inflammatory responses while replicating in the cytosol of macrophages. The means by which F. tularensis modulates macrophage activation are not fully elucidated. In this study, we demonstrate that virulent F. tularensis impairs production of inflammatory cytokines in primary macrophages by preventing their shift to aerobic glycolysis, as evidenced by the downregulation of hypoxia inducible factor 1α and failure to upregulate pfkfb3. We also show that Francisella capsule is required for this process. In addition to modulating inflammatory responses, inhibition of glycolysis in host cells is also required for early replication of virulent Francisella. Taken together, our data demonstrate that metabolic reprogramming of host cells by F. tularensis is a key component of both inhibition of host defense mechanisms and replication of the bacterium.
Rare Bone Marrow Biopsy Complication: A Challenging Case of Sacroiliitis and Staphilococcus aureus Sepsis
Authors: Morotti Alessandro , Consiglio Barozzino Maria , Guerrasio Angelo
Published: March 2016

Bone marrow biopsy is a mandatory procedure to diagnose several hematological disorders. This invasive analysis is generally safe and the procedure-related risks are rare and include bleeding at the site of puncture and, very occasionally, local infections. Here, we describe a case of sacroiliitis that occurred as a consequence of bone marrow biopsy.
Effect of Intravenous Iron Supplementation on Iron Stores in Non-Anemic Iron-Deficient Patients with Hereditary Hemorrhagic Telangiectasia
Authors: Karlsson Torbjörn , Cherif Honar
Published: March 2016

In hereditary hemorrhagic telangiectasia (HHT), frequent episodes of nasal and gastrointestinal bleeding commonly lead to irondeficiency with or without anemia. In the retrospective study presented here we assessed the iron stores, as determined by analysis of plasma ferritin, during oral and intravenous iron supplementation, respectively, in a population of iron-deficient non-anemic HHT patients who were inadequately iron-repleted by oral supplementation. A switch from oral to intravenous iron supplementation was associated with a significant increase in ferritin in this patient population.
Pityriasis rosea, Gianotti-Crosti syndrome, asymmetric periflexural exanthem, papular-purpuric gloves and socks syndrome, eruptive pseudoangiomatosis, and eruptive hypomelanosis: do their epidemiological data substantiate infectious etiologies?
Authors: Chuh Antonio , Zawar Vijay , Sciallis Gabriel F. , Kempf Werner , Lee Albert
Published: March 2016

Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papularpurpuric gloves and socks syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future.
Design of Probabilistic Random Forests with Applications to Anticancer Drug Sensitivity Prediction
Authors: Rahman Raziur , Haider Saad , Ghosh Souparno , Pal Ranadip
Published: March 2016

Random forests consisting of an ensemble of regression trees with equal weights are frequently used for design of predictive models. In this article, we consider an extension of the methodology by representing the regression trees in the form of probabilistic trees and analyzing the nature of heteroscedasticity. The probabilistic tree representation allows for analytical computation of confidence intervals (CIs), and the tree weight optimization is expected to provide stricter CIs with comparable performance in mean error. We approached the ensemble of probabilistic trees’ prediction from the perspectives of a mixture distribution and as a weighted sum of correlated random variables. We applied our methodology to the drug sensitivity prediction problem on synthetic and cancer cell line encyclopedia dataset and illustrated that tree weights can be selected to reduce the average length of the CI without increase in mean error.
Вырождения кэлеровых K3-поверхностей с конечными симплектическими группами автоморфизмов. II
Authors: Nikulin Viacheslav Valentinovich
Published: March 2016

Доказывается основная гипотеза 7.1 статьи [1]. С помощью этого результата классифицируются
вырождения коразмерности 1 кэлеровых K3-поверхностей с конечными симплектическими группами автоморфизмов.
Библиография: 20 наименований.
Задача Гурса для дробного телеграфного уравнения с производными Капуто
Authors: Pshibikhova Rita A
Published: March 2016

Исследуется задача Гурса для дробного телеграфного уравнения
с производными Капуто. Доказана теорема существования и
единственности решения задачи.
Библиография: 7 названий.
Квазиторические многообразия и малые накрытия над правильно окрашенными многогранниками: вложения и погружения
Authors: Baralic Djordje Borisav , Grujic Vladimir N.
Published: March 2016

Строятся малые накрытия и квазиторические многообразия над простыми $n$-мерными многогранниками, допускающими правильную раскраску гиперграней в $n$ цветов. Вычисляются классы Штифеля-Уитни этих
многообразий как препятствия к их вложению в евклидовы пространства. Самая большая размерность, необходимая для вложения, достигается в случае, если $n$ - степень двойки.
Библиография: 11 названий.
Об аппроксимации траекторного аттрактора 3D системы Навье-Стокса различными $\alpha$-моделями гидродинамики
Authors: Chepyzhov Vladimir Victorovich
Published: March 2016

Изучаются пределы при $\alpha\to 0{+}$ долговременной динамики различных приближенных $\alpha$-моделей вязкой несжимаемой жидкости и их связь с траекторным аттрактором точной 3D системы Навье-Стокса. Рассматриваемые $\alpha$-модели разделены на два класса в зависимости от свойств ортогональности нелинейных членов уравнений, порождающих каждую конкретную $\alpha$-модель. Показано, что аттракторы $\alpha$-моделей класса I имеют более сильные свойства притяжения своих траекторий, чем аттракторы
$\alpha$-моделей класса II. Для обоих классов доказано, что ограниченные семейства траекторий рассмотренных $\alpha$-моделей сходятся в соответствующей слабой топологии к траекторному
аттрактору $\mathfrak A_0$ точной 3D системы Навье-Стокса, когда время $t$ стремится к бесконечности. Кроме того, установлено, что траекторный аттрактор $\mathfrak A_\alpha$ каждой $\alpha$-модели сходится в той же топологии к аттрактору $\mathfrak A_0$ при $\alpha\to 0{+}$. Для всех $\alpha$-моделей построены минимальные пределы $\mathfrak A_{\min}\subseteq\mathfrak A_0$ их траекторных аттракторов $\mathfrak A_\alpha$ при $\alpha\to 0{+}$. Доказано, что каждое такое множество $\mathfrak A_{\min}$ является компактной компонентой связности траектороного аттрактора $\mathfrak A_0$, причем все $\mathfrak A_{\min}$ строго инвариантны под действием полугруппы трансляций.
Библиография: 39 названий.
Micromuseology An Analysis of Small Independent Museums
Authors: Candlin Fiona
Published: March 2016

How would our understanding of museums change if we used the Vintage Wireless Museum or the Museum of Witchcraft as examples – rather than the British Museum or the Louvre? Although there are thousands of small, independent, single-subject museums in the UK, Europe and North America, the field of museum studies remains focused almost exclusively on major institutions.

In this ground-breaking new book, Fiona Candlin reveals how micromuseums challenge preconceived ideas about what museums are and how they operate. Based on extensive fieldwork and analysis of more than fifty micromuseums, she shows how they offer dramatically different models of curation, interpretation and visitor experience, and how their analysis generates new perspectives on subjects such as display, objects, collections, architecture, and the public sphere.

The first-ever book dedicated to the subject, Micromuseology provides a platform for radically rethinking key debates within museum studies. Destined to transform the field, it is essential reading for students and researchers in museum studies, anthropology, material culture studies, and visual culture.
Meritocracy and the University
Authors: Zimdars Anna Mountford
Published: March 2016

Based on a hundred interviews with some of the key stakeholders in university admissions, and statistics from both primary and secondary sources, this book explains the values, processes and practices that judge some individuals as worthy of getting an education at elite universities and deny admission to other applicants.

By juxtaposing the UK and US systems the book invites readers from both sides of the Atlantic to see the familiar as strange and to reflect on the underlying values behind the selection of students. It illustrates how particular discussions of meritocracy affect individuals and relate to the history and social climate of each nation.
Porous aerosol in degassing plumes of Mt. Etna and Mt. Stromboli
Authors: Shcherbakov Valery , Jourdan Olivier , Voigt Christiane , Gayet Jean-Francois , Chauvigne Aurélien , Schwarzenboeck Alfons , Minikin Andreas , Klingebiel Marcus , Weigel Ralf , Borrmann Stephan , Jurkat Tina , Kaufmann Stefan , Schlage Romy , Gourbeyre Christophe , Febvre Guy , Lapyonok Tatsiana , Frey Wiebke , Molleker Sergej , Weinzierl Bernadett
Published: March 2016

Abstract. Aerosols of the volcanic degassing plumes from Mt. Etna and Mt. Stromboli were probed with in situ instruments on board the Deutsches Zentrum für Luft- und Raumfahrt research aircraft Falcon during the contrail, volcano, and cirrus experiment CONCERT in September 2011. Aerosol properties were analyzed using angular scattering intensities and particle size distributions simultaneously measured with the Polar Nephelometer and the Forward Scattering Spectrometer probes (FSSP series 100 and 300), respectively. Aerosols of degassing plumes are characterized by low values of the asymmetry parameter (between 0.6 and 0.75); the effective diameter was within the range of 1.5–2.8 µm and the maximal diameter was lower than 20 µm. A principal component analysis applied to the Polar Nephelometer data indicates that scattering features of volcanic aerosols of different crater origins are clearly distinctive from angular scattering intensities of cirrus and contrails. Retrievals of aerosol properties revealed that the particles were "optically spherical" and the estimated values of the real part of the refractive index are within the interval from 1.35 to 1.38. The interpretation of these results leads to the conclusion that the degassing-plumes aerosols were porous with air voids. Our estimates suggest that aerosol particles contained about 18 to 35 % of air voids in terms of the total volume.
Adjusting particle-size distributions to account for aggregation in tephra-deposit model forecasts
Authors: Mastin Larry G. , Van Eaton Alexa R. , Durant Adam J.
Published: March 2016

Abstract. Volcanic ash transport and dispersion models (VATDs) are used to forecast tephra deposition during volcanic eruptions. Model accuracy is limited by the fact that fine ash aggregates, altering patterns of deposition. In most models this is accounted for by ad hoc changes to model input, representing fine ash as aggregates with density ρagg, and a log-normal size distribution with median μagg and standard deviation σagg. Optimal values may vary between eruptions. To test the variance, we used the Ash3d tephra model to simulate four deposits: 18 May 1980 Mount St. Helens; 16–17 September 1992 Crater Peak (Mount Spurr); 17 June 1996 Ruapehu; and 23 March 2009 Mount Redoubt. In 158 simulations, we systematically varied μagg and σagg, holding ρagg constant at 600 kg m−3. We evaluated the fit using three indices that compare modeled versus measured (1) mass load at sample locations; (2) mass load versus distance along the dispersal axis; and (3) isomass area. For all deposits, under these inputs, the best-fit value of μagg ranged narrowly between ~ 2.1–2.5 φ (0.23–0.18 mm), despite large variations in erupted mass (0.25–50 Tg), plume height (8.5–25 km), mass fraction of fine (< 0.063 mm) ash (3–59 %), atmospheric temperature, and water content between these eruptions. This close agreement suggests that aggregation may be treated as a discrete process that is insensitive to eruptive style or magnitude. This result offers the potential for a simple, computationally-efficient parameterization scheme for use in operational model forecasts. Further research may indicate whether this narrow range also reflects physical constraints on processes in the evolving cloud.
Dimensioning IRGA gas sampling systems: laboratory and field experiments
Authors: Aubinet Marc , Joly Lilian , Loustau Denis , De Ligne Anne , Chopin Henri , Cousin Julien , Chauvin Nicolas , Decarpenterie Thomas , Gross Patrick
Published: March 2016

Abstract. Both laboratory and field experiments were carried out in order to define suitable configuration ranges for the gas sampling systems (GSSs) of infrared gas analyzers (IRGAs) used in eddy covariance measurements.In the laboratory, an original dynamic calibration bench was developed in order to test the frequency attenuation and pressure drop generated by filters. In the field, three IRGAs of the same type equipped with different filters or different rain caps were installed and run and the real frequency response of the complete setup was tested. The main results are as follows. – Filters may have a strong impact on the pressure drop in the GSS and this impact increases with flow rate. – Conversely, no impact of the tested filters on cut-off frequency was found, GSSs with and without filters presenting similar cut-off frequencies. – The main limiting factor of cut-off frequency in the field was found to be the rain cap design. In addition, the impact of this design on pressure drop was also found to be noteworthy.
The Investigation of Builders and Building Supervisors’ Responsibility in Iran Law
Authors: Zadeh Marjan Hossein , Afrough Abdolmohammad
Published: March 2016

As a professional career, builders and building supervisors’ activities is accepted as an especial liability from legislator’s point of view and every especial liability has its own technical its bylaws, the building control engineering system and national building regulations were provided and ratified that are necessary for the sake of security and protection of the buildings and structures and they are essential as the most basic civil rights. With analysis of relevant laws and regulations we realize that builders and supervisors’ responsibility is assumed as building fault-based liability by the legislator and liability without fault is an exception of the fault principle and the injured party to claim compensation of loss does not need to prove fault, so the builders and supervisors must take utmost caution in this regard. But about how, when and who they can plan their complaints, aside from the client, third parties such as buyers, passengers, entrants to the construction site and owner’s adjacent can all sue against the above-mentioned persons and all of them are relatively liable for damages to life and property losses of injured persons.
Role of Youth Diplomacy in Governments' Foreign Relationships by Using YNGOs Capacity (Youth Non-governmental Organizations)
Authors: Modaber Rohollah
Published: March 2016

In current world, regarding the daily event occur in human communications domain, the process of international problems causes blurring the role of governments and this new situation leads to evolution in common traditional diplomacy of past centuries. Parallel with the communities' evolution, it is evident, new scenarios engender in diplomacy and international relations arena which seek the modern preferences along methods adoption and modern means like using non-governmental players capacity especially NGOs. Regarding the youth role-playing in various countries specially developed onesas a thinking, work and providing ideas forces in institutions, scientific and administrative centers and the YNGOsdevelopment process in the global system along various programs including welfare and philanthropic measures beyond the countries' boundary; and creating active youth global network and developing this network in most youth communities along influence in philanthropic and universal programs in international arena which causes the influence on the minds of different masses of people and even governments and international organizations; new discourse with the title of youth diplomacy as modern diplomacy is created. Therefore, the present study aimed toinvestigate what is the role of youth diplomacy in developing philanthropic discourse and promoting welfare measures in international system by using NGOs. It seems, meanwhile, moving in the way of developing mutual understanding among youth in other countries, who has motivation and concerns to encounter the spread of war, ethnic conflicts, migration, the spread of AIDS, environmental degradation and other similar cases; will be the reason of the creation of the effective youth global network in countries along governments and YNGOs-orientated by unofficial meanshave the approach of achieving a better future in order to achieve the peace and pressure on the governments have the role in promoting violence and extremism.
The Rule/Principle of No Loss at Perspective of Five Religions
Authors: Hesari Hamed Mostaeed , Zadeh Javad Vahedi
Published: March 2016

The present study examines juridical aspects of principle of no loss. The major basis of this principle is justice. Perhaps because of this reason, “principle of no loss” has priority over the rest of arguments like private and public and etc. Or it has control over generality and universality and applicability of arguments. And here, the view of jurists and lawyers is different at giving right prejudicial or give it to the injured party. This is the assumption that has been considered in most verses and hadith evidence of the principle of no loss. This indicates that “the idea of changing circumstance” before known in European rights, it had known at the rights of Islamic law centuries ago. Regarding to the views of Sunni religious leaders and scholars after them-it is clear that Sunni jurisprudence has no clear criteria for principle of no loss. Although, in many cases, Sunni religious leaders have considered the nature of the harm, but because in practice the current principle could not solve all of the issues and problems, therefore, they have resort other criteria and finally they resort to preference and correction.
Reviewer Acknowledgements for Journal of Politics and Law, Vol. 9, No. 2
Authors: Sheng Vivian
Published: March 2016

Reviewer acknowledgements for Journal of Politics and Law, Vol. 9, No. 2, 2016.
Factors Affecting Generation Y Employees’ Intention to Quit in Malaysian’s Business Process Outsourcing Sector
Authors: Queiri Abdelbaset , Dwaikat Nizar
Published: March 2016

This paper investigates the factors contributing to Generation Y employees’ intention to quit in the business process outsourcing sector (BPO) in Malaysia from four different perspectives: personnel dimensions (work overload, role ambiguity and job stress), job attitudes (satisfaction with pay and organizational commitment), work-life conflict and organizational strategies (training, career planning and empowerment). A structural equation modelling approach was employed to identify the variables that significantly affect the intention to quit. Using Amos 18, data collected from 164 Generation Y employees in the BPO sector were used to test the hypotheses. The results showed that intention to quit one’s job is explained by lack of training, lack of empowerment, organizational commitment, and lack of career planning. Also, role ambiguity and satisfaction with pay exert negative indirect effects on the intention to quit one’s job through organizational commitment. Additionally, job stress has no impact on the intention to quit one’s job. This study is considered to be among the few attempts to address the reasons behind Generation Y employees' intention to quit.
Heart Drawing: A New Diagnostic Tool
Authors: Becker-Weidman Arthur
Published: March 2016

This paper presents a methodology for assessing a child’s capacity to identify primary affective states, affect regulation, and affective experiences in a non-threatening manner. The methodology can be used with children from ages three years thru age nineteen years.

Background

A thorough assessment includes an evaluation of a person’s capacity to identify and regulate emotions. Affect regulation requires the capacity to identify internal experiences of emotions. The Heart Drawing was developed as a non-threatening method for assessing a child’s capacity to identify emotions. Most children enjoy drawing and the Heart Drawing is usually experienced by the child as non-threatening and enjoyable.

The Heart Drawing is a new, easy to use, and efficient tool that allows the clinician to assess a child’s affect regulation functioning, affective range, and experience in a non-threatening manner. It can also be used to assess a child’s insightfulness and capacity to identify internal affective experiences.

Method

The child is asked to select colors for the feelings expressive of mad, sad, glad, and scared from a group of nine primary colors. The child is then asked to draw a heart and to fill in the heart with the amount of each feeling that the child usually feels.

Results

Administration and discussion usually takes ten to fifteen minutes.

Conclusion

The article presents examples of drawings by children with various diagnoses and conditions along with a normative drawing for comparison. The methodology has been found to be very helpful in assessing a child’s emotional status and capacity to regulate emotions.

Key Practitioner Message

1)       Emotional regulation and the capacity to identify emotions is important for evaluation and treatment.

2)       Projective drawing methods can be useful in assessing a person’s ability to identify and regulate emotions.

3)       The Heart Drawing is an efficient and effective method for assessing a person’s capacity to identify and regulate emotions.
Analytical Method Validation and Quality Control of a Seven-Herb Chinese Medicine Formulation Used for the Treatment of Irritable Bowel Syndrome with Constipation
Authors: Lee Samiuela , Khoo Cheang S , Pearson Jarryd L , Bourchier Suzannah J , Bensoussan Alan
Published: March 2016

There is a need for increased QC of complex herbal medicine formulations to ensure product consistency, efficacy, and safety. This study reports an HPLC with photodiode array and electrospray ionization–tandem MS method for quantifying selected analytes in a seven-herb formulation. Fourteen analytes were selected for quantification based on the criteria available from the Herbal Chemical Marker Ranking System, which takes into account the bioavailability, reported bioactivity, and physiological action related to its intended use, as well as commercial availability of the standard. After optimizing the columns and chromatographic conditions, 13 of the 14 analytes were able to be determined in one run, with the remaining analyte analyzed on its own. The method was successfully applied to two different extracts of the formulation, demonstrating an application for the QC of a complex herbal mixture with respect to their chemical characteristics.
Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition
Authors: Sanfrancesco Joseph , McKenney Jesse K. , Leivo Mariah Z. , Gupta Sounak , Elson Paul , Hansel Donna E.
Published: March 2016

Context.—Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques.

Objective.—To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-to-mesenchymal transition.

Design.—Twenty-eight cases of sarcomatoid UCa were rereviewed. Clinical outcomes were obtained through database search. Immunohistochemistry for clinical and epithelial-to-mesenchymal transition markers was performed.

Results.—All patients had biopsy-proven invasive UCa; 61% (17 of 28) had sarcomatoid UCa at initial diagnosis. A recognizable epithelial component(s) was present in 17 lesions. The sarcomatoid component accounted for 65% of the lesion (average), with heterologous elements present in 3 of 28 cases (11%). The morphologic spectrum of the sarcomatoid element included spindled not otherwise specified, myxoid, pseudoangiosarcomatous, and malignant fibrous histiocytoma–like undifferentiated features. The sarcomatoid component was immunoreactive for pancytokeratin (22 of 26; 85%), p63 (20 of 26; 77%), cytokeratin 903 (17 of 26; 65%), cytokeratin 7 (16 of 26; 62%), GATA3 (16 of 26; 62%), and cytokeratin 5/6 (16 of 26; 62%). STAT-6, CD31, CD34, and HMB45 were all nonreactive, whereas smooth muscle actin often showed at least focal immunoreactivity (22 of 26; 85%). Epithelial-to-mesenchymal transition markers were frequently expressed, including vimentin (26 of 26; 100%), FoxC2 (26 of 26; 100%), SNAIL (23 of 26; 88.5%), and ZEB1 (18 of 26; 69.2%). Follow-up was available for 24 patients (median, 7 months). Sixteen of 28 patients (57%) died of disease (overall mean survival, 9.1 months). The presence of myxoid or chordoid features was associated with reduced survival (P < .05).

Conclusions.—Sarcomatoid UCa is an aggressive form of UCa that frequently expresses epithelial-to-mesenchymal transition markers, suggesting a possible mechanism associated with aggressive tumor behavior.
Número Completo jan./mar. 2016 (PDF com Capa e Artigos)
Authors: Rural Extensão
Published: March 2016

http://dx.doi.org/10.5902/2318179621492Número Completo jan./mar. 2016 (PDF com Capa e Artigos)
Chondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving Chondrogenesis
Authors: Corradetti Bruna , Taraballi Francesca , Minardi Silvia , Van Eps Jeffrey , Cabrera Fernando , Francis Lewis W. , Gazze Salvatore A. , Ferrari Mauro , Weiner Bradley K. , Tasciotti Ennio
Published: March 2016

Costs associated with degenerative inflammatory conditions of articular cartilage are exponentially increasing in the aging population, and evidence shows a strong clinical need for innovative therapies. Stem cell-based therapies represent a promising strategy for the treatment of innumerable diseases. Their regenerative potential is undeniable, and it has been widely exploited in many tissue-engineering approaches, especially for bone and cartilage repair. Their immune-modulatory capacities in particular make stem cell-based therapeutics an attractive option for treating inflammatory diseases. However, because of their great plasticity, mesenchymal stem cells (MSCs) are susceptible to different external factors. Biomaterials capable of concurrently providing physical support to cells while acting as synthetic extracellular matrix have been established as a valuable strategy in cartilage repair. Here we propose a chondroitin sulfate-based biomimetic scaffold that recapitulates the physicochemical features of the chondrogenic niche and retains MSC immunosuppressive potential in vitro, either in response to a proinflammatory cytokine or in the presence of stimulated peripheral blood mononuclear cells. In both cases, a significant increase in the production of molecules associated with immunosuppression (nitric oxide and prostaglandins), as well as in the expression of their inducible enzymes (iNos, Pges, Cox-2, and Tgf-β). When implanted subcutaneously in rats, our scaffold revealed a reduced infiltration of leukocytes at 24 hours, which correlated with a greater upregulation of genes involved in inflammatory cell apoptotic processes. In support of its effective use in tissue-engineering applications of cartilage repair, the potential of the proposed platform to drive chondrogenic and osteogenic differentiation of MSC was also proven.

Significance

Recently, increasing clinical evidence has highlighted the important role of proinflammatory mediators and infiltrating inflammatory cell populations inducing chronic inflammation and diseases in damaged cartilage. This work should be of broad interest because it proposes an implantable biomimetic material, which holds the promise for a variety of medical conditions that necessitate the functional restoration of damaged cartilage tissue (such as trauma, diseases, deformities, or cancer).
Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells
Authors: Tang Zi-Hua , Chen Jia-Rong , Zheng Jing , Shi Hao-Song , Ding Jie , Qian Xiao-Dan , Zhang Cui , Chen Jian-Ling , Wang Cui-Cui , Li Liang , Chen Jun-Zhen , Yin Shan-Kai , Huang Tao-Sheng , Chen Ping , Guan Min-Xin , Wang Jin-Fu
Published: March 2016

The genetic correction of induced pluripotent stem cells (iPSCs) induced from somatic cells of patients with sensorineural hearing loss (caused by hereditary factors) is a promising method for its treatment. The correction of gene mutations in iPSCs could restore the normal function of cells and provide a rich source of cells for transplantation. In the present study, iPSCs were generated from a deaf patient with compound heterozygous MYO7A mutations (c.1184G>A and c.4118C>T; P-iPSCs), the asymptomatic father of the patient (MYO7A c.1184G>A mutation; CF-iPSCs), and a normal donor (MYO7AWT/WT; C-iPSCs). One of MYO7A mutation sites (c.4118C>T) in the P-iPSCs was corrected using CRISPR/Cas9. The corrected iPSCs (CP-iPSCs) retained cell pluripotency and normal karyotypes. Hair cell-like cells induced from CP-iPSCs showed restored organization of stereocilia-like protrusions; moreover, the electrophysiological function of these cells was similar to that of cells induced from C-iPSCs and CF-iPSCs. These results might facilitate the development of iPSC-based gene therapy for genetic disorders.

Significance

Induced pluripotent stem cells (iPSCs) were generated from a deaf patient with compound heterozygous MYO7A mutations (c.1184G>A and c.4118C>T). One of the MYO7A mutation sites (c.4118C>T) in the iPSCs was corrected using CRISPR/Cas9. The genetic correction of MYO7A mutation resulted in morphologic and functional recovery of hair cell-like cells derived from iPSCs. These findings confirm the hypothesis that MYO7A plays an important role in the assembly of stereocilia into stereociliary bundles. Thus, the present study might provide further insight into the pathogenesis of sensorineural hearing loss and facilitate the development of therapeutic strategies against monogenic disease through the genetic repair of patient-specific iPSCs.
Huancas and Rituals of Fertility in the farming Landscape of the Northern Calchaqui Valley (Salta, Argentina)
Authors: Páez María Cecilia , Marinangeli Gimena Alé
Published: March 2016

In this article, we describe the material record associated with the ritual performances of prehispanic farming communities in Las Pailas (Salta Province, Argentina), and how these practices are maintained and resignified by current inhabitants of the area. The archaeological site of Las Pailas located in the northern Calchaqui Valley was an enclave composed of a large farming area and a complex hydraulic network that was continuously occupied from the beginning of the Christian era to the Spanish invasion. Las Pailas features several huancas, elongated stones characterized as menhirs or monoliths, which are located in the center of farming enclosures individually or in pairs. Based on their different morphologies and sizes, they were classified into five types. The analysis of the huancas and their locations, together with information obtained from oral histories, suggests that these features were associated with agricultural fertility rituals. Even today, these stones are important informing contexts, although their meaning has been resignified in a new social and cultural context
An extensive program of periodic alternative splicing linked to cell cycle progression
Authors: Dominguez Daniel , Tsai Yi-Hsuan , Weatheritt Robert , Wang Yang , Blencowe Benjamin J , Wang Zefeng
Published: March 2016

Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing (AS) in the temporal control of cell cycle is not well understood. By sequencing the human transcriptome through two continuous cell cycles, we identify ~1300 genes with cell cycle-dependent AS changes. These genes are significantly enriched in functions linked to cell cycle control, yet they do not significantly overlap genes subject to periodic changes in steady-state transcript levels. Many of the periodically spliced genes are controlled by the SR protein kinase CLK1, whose level undergoes cell cycle-dependent fluctuations via an auto-inhibitory circuit. Disruption of CLK1 causes pleiotropic cell cycle defects and loss of proliferation, whereas CLK1 over-expression is associated with various cancers. These results thus reveal a large program of CLK1-regulated periodic AS intimately associated with cell cycle control.