bluuebunny/crossref_metadata_2025 huggingface dataset:
De DE para COM. A Bolha: teatro com Marionetas e a relação entre marioneta e marionetista
Authors: Ferreira Ana Mota , Bilro Manel
Published: January 2024

O marionetista visível e ativo em cena potenciou um sem-número de outras possibilidades e a mistura de outras disciplinas artísticas nos espetáculos. Este é o conceito que A Bolha – Teatro com Marionetas implementa nos seus processos criativos, promovendo a relação direta e próxima entre marioneta e marionetista, com ênfase na complementaridade entre ambos. A abordagem metodológica e técnicas de trabalho e pesquisa são apresentadas, segundo uma perspetiva pessoal dos diretores criativos da estrutura artística, bem como influências teóricas e bases funcionais para os processos de construção de marionetas e dramaturgias. A marioneta assume uma nova dimensão no espaço cénico, resultado de novas abordagens práticas e de uma relação de complementaridade com o ator, e A Bolha pretende explorar e dar continuidade a essa dimensão.
Changing geography through translation, quotation and periodicals: the Viscount of Santarém and the Question of Casamance (1836–1843)
Authors: Maia Rita Bueno
Published: January 2024

The present article aims to explore a historical episode in which an act of translation managed to change the map of Portugal’s colonial possessions in Africa. It discusses the strategies employed by the Portuguese Viscount of Santarém to help the Portuguese government reclaim its rights to territories in Guinea in the 1840s, while conceiving translation as a purposeful act (Vermeer, 1989) composed of three moments: pre-translation, translation, and post-translation (Gentzler, 2017). By shedding light on the Viscount’s actions, which can be traced through his letters (Santarém, 1919), the article will demonstrate the key role played by rewrites and their citation in scientific and political journals in Portugal’s victory over France in the “Question of the Casamance”. To be more precise, the translation action involved: the publication of an intralingual translation of a manuscript thatwas believedto prove that Portuguese explorers were the first to arrive in Guinea; the writing of a scholarly work that served as a Portuguese-language epitext to the translation; the self-translation of the epitext into the academic lingua franca; and the use of influence and money to get periodicals to quote, publish, and discuss excerpts from the three rewritings.
Literacia tradutória e intertextualidade: estudo de caso na tradução literária direta do polaco para o português europeu
Authors: Swiatkiewicz Teresa Fernandes
Published: January 2024

Partindo da noção lata de competência tradutória que discrimina os diferentes saberes e capacidades do tradutor literário e assumindo que, quanto mais alargado for o leque de leituras feitas por um tradutor na cultura de chegada, maior será o seu repertório linguístico, literário e cultural, lança-se a hipótese de que memórias de textos lidos pelos tradutores na língua de chegada possam ressurgir ou transparecer na escrita tradutória sob a forma de citações e ecos intertextuais. O tópico a investigar equaciona competência tradutória, literacia, tradução e intertextualidade com o objetivo de encontrar ocorrências de intertextualidades não sugeridas pelos textos de partida e, sim, criadas pelos tradutores nos textos de chegada, que remetam para textos escritos em português. O corpus reunido para análise compreende obras literárias em prosa e poesia, traduzidas diretamente do polaco para o português, entre 1990 e 2010, em Portugal.
Antero de Quental. Zara. Edição poliglota. Organização, posfácio e notas de Andrea Ragusa. Edições do Saguão, 2022.
Authors: Molder Maria Filomena
Published: January 2024

Recensão do livro Zara. Edição poliglota, de Antero de Quental, com organização, posfácio e notas de Andrea Ragusa, publicado pelas Edições do Saguão em 2022.
Radiation-induced changes in the properties and functions of fibroblasts
Authors: Matveyenkava T. D. , Nazarenko I. V. , Yurkovskiy А. М. , Starodubtseva M. N.
Published: January 2024

This review is devoted to the analysis of the literature containing experimental and clinical data on radiation-induced changes in connective tissue and its cellular component to create an overall picture of the leading mechanisms of radiation fibrosis development.The review analyzed publications for the period 1995-2022, presented in three academic databases: Scopus, PubMed and Web of Science. In the search process, various combinations of logical operators (or, and, not) were used to combine search keywords (ionizing radiation, connective tissue, fibroblasts) to find relevant studies in academic databases. The development of radiation fibrosis is determined by radiation-induced changes in the properties and functions of fibroblasts. The article discusses the main biological effects of irradiation of fibroblastic cells with X-ray, gamma and alpha radiation, presents the mechanisms of radiation-induced differentiation in the fibroblast/myofibroblast system, and also notes the role of connective tissue microenvironment and oxidative stress associated with mitochondria in this process. The main experimentally established effects presented in the review and the general scheme of the mechanisms of non-lethal action of ionizing radiation on fibroblasts contribute to a better understanding of the mechanisms of radiation-induced fibrosis development
Levels of interleukins-1β, -2, -6, -8 in the blood of patients with local wounds at various stages of the infectious process
Authors: Yarets Yu. I.
Published: January 2024

Objective. To evaluate the levels of interleukins (IL) -1β, -2, -6, -8 in the blood serum of patients with wounds, depending on the clinical and microbiological characteristics of the wound process.Materials and methods. The evaluation of IL-1ß, IL-2, IL-6, IL-8 indices in the blood serum of 206 patients with wounds was carried out. When analyzing changes in IL, the clinical and microbiological characteristics of the wound process were taken into account.Results. Changes in the levels of IL-1ß, IL-2, IL-6 and IL-8 in the blood of patients with wounds are determined by the duration of the wound process, the presence of clinical signs of inflammation and the presence of microorganisms in the wound. The absence of a systemic response to the presence of potential pathogens (S. aureus) in an acute wound, when IL levels do not exceed 10 pg/ml, can serve as an additional criterion for contamination with minimal wound life (up to 4 days). Preservation of high values of IL-8 from 38.16 pg/ml (33.31; 42.11), no changes in IL-2 (no more than 2.23 pg/ml (1.41; 4.01)) in the blood of patients with wounds which duration exceeds 22 days is a sign of a violation of the healing process and the formation of a chronic wound. The level of IL-6 is recommended as an additional criterion determining the progression of the infectious process in patients with wounds, when an increase in IL-6 values is recorded from 18.79 pg/ml (15.71; 23.01) at critical colonization to 51.65 pg/ml (35.19; 51.95) at the stage of wound infection. IL-6 values of no more than 10 pg/ml indicate the absence of an active inflammatory process.Conclusion. The levels of proinfl ammatory interleukins in the blood of patients can serve as additional laboratory criteria determining the disruption of wound healing and progression of the wound infection process.
Sarcopenia: features of manifestation in patients with diabetes mellitus
Authors: Naumenava Ya. L. , Makhlina A. S. , Haurylenka D. I. , Bartnovskaya M. N. , Demyanenko I. N.
Published: January 2024

Objective. To evaluate the parameters of sarcopenia (SP) and the factors affecting them in patients with diabetes mellitus (DM).Materials and methods. A study of 87 hospitalized patients with DM (29 men — 33% and 58 women — 67%) aged 21 to 61 years was conducted. The study included the determination of clinical and laboratory parameters, including anthropometric data, laboratory parameters, determination of sarcopenia parameters (muscle mass, muscle strength, muscle function), ultrasound examination of skeletal muscles.Results. A decrease in muscle mass was observed in 11% of patients with DM and depends on the composition of the body. A decrease in muscle function was observed in 30% of patients with DM and depends on the patient’s age (over 41 years; AUS — 0.826; p < 0.001) and the degree of excess body weight (in 87% of patients, BMI is more than 30 kg/m2). A decrease in muscle strength was noted in 44% of patients and depends on the severity of diabetic neuropathy (more than 1 point according to the results of the NDSm scale; AUS — 0.876; p < 0.001). The circumference of the lower leg is positively correlated with the thickness of the intermediate broad thigh muscle (rs = 0.44; p < 0.05) and the thickness of the musculoskeletal fold (rs = 0.70; p < 0.05), determined by ultrasound technique.Conclusion. The probability of SP was noted in 44% of patients with DM and depends on the length of DM and the severity of diabetic neuropathy. Muscle function is reduced in 30% of patients with DM and is associated with the patient’s age and overweight. A decrease in muscle mass was observed in 11% of patients with DM and depends on the composition of the body. The thickness of the intermediate broad thigh muscle and the thickness of the musculoskeletal fold at the hip level (according to ultrasound results) are significantly interrelated with muscle mass.
Improved method of hemostasis for the middle rectal artery
Authors: Kuzmenko A. V. , Zhdanovich V. N.
Published: January 2024

Objective. To obtain data on the comparative characteristics of traditional and improved methods of hemostasis for the middle rectal artery (MRA).Materials and methods. The material for the sectional study was 206 corpses of men (the age of the deceased was from 22 to 82 years, the average age was 57 years) and 113 corpses of women (the age of the deceased was from 32 to 93 years, the average age was 63 years). To achieve the purpose of the study, the following methods were used: vascular injection, dissection, statistical processing. 85 patients of both sexes aged from 57 to 75 years were selected to conduct the clinical part of the study at Gomel Regional Specialized Clinical Hospital. Among them, 50 people were in the comparison group and 35 people were in the main group. All patients were diagnosed with stage I or II rectal cancer. The operative technique for performing hemostasis on the MRA during anterior rectal resection in the comparison group included sequential ligation and stitching between the clamps first of the distal third of the length of this artery, and then its proximal third. In the main group, the method of hemostasis for MRA was supplemented by ligation and stitching of this vessel in the middle third of its length. Statistical data processing included parametric and nonparametric methods of comparative analysis.Results. On cadaveric material, it was found that most of the extraorgan anastomoses of the MRA both in men and women have been localized in the middle third of this artery. The results obtained during the clinical study demonstrate the superiority of the improved hemostasis method for MRA over the traditional method. The proposed method includes additional ligation and stitching of the middle third of the MRA.Conclusion. The improved hemostasis method for MRA in anterior rectal resection is highly effective, which makes it possible to recommend it as the method of choice in the surgical treatment of upper ampullary rectal cancer of stage I or II.
Locoregional recurrences of breast cancer after reconstructive plastic and organ-preserving surgery
Authors: Ganusevich O. N. , Nesterovich T. N. , Fedarkevich I. V. , Achinovich S. L. , Los’ D. M. , Kontsevenko I. V.
Published: January 2024

Objective. To analyze locoregional relapses (LRR) after reconstructive plastic and organ-preserving operations in breast cancer (BC)Materials and methods. A retrospective analysis of the results of the treatment of 303 patients with BC who underwent reconstructive plastic and organ-preserving operations in the period from 2014 to 2019 in the Oncological Department of General Oncology and Rehabilitation of Gomel Regional Clinical Oncological Dispensary was carried out. The median age was 44 years (25-70 years). Statistical data processing was carried out using the application software package “Statistica”, 10.0. To characterize the surveyed groups, a standard methodological approach based on the calculation of descriptive statistics data was used. In order to statistically assess the relationship between the frequency of relapses depending on the stage and the molecular biological type of neoplasm, the Spearman correlation coeffi cient was used. The accepted level of statistical signifi cance (p) was 0.05.Results. Locoregional relapses were recorded in 11 (3.6%) patients, of which local — in 8 (2.6%), regional — in 3 (1.0%). The minimum period of development of LRR was 15 months, the maximum was 74 months; the median period of occurrence of LRR was 47 months. Depending on the stage of breast cancer, relapses developed: at stage I — in 4 (3.7%) cases, II — 5 (3.5%), III — 2 (4.2%). Depending on the molecular biological subtype of the neoplasm, LRR were distributed as follows: with luminal A — 1 (1.3%) case, luminal In HER2-negative — 1 (0.9%), luminal In HER2-positive — 6 (9.7%), non-luminal HER2-positive 1 (6.3%), three times negative — 2 (5.6%). Discordance of the receptor status was detected in 8 (72.7%) patients with recurrent tumor, most often due to the loss or decrease in the number of progesterone receptors (PR). The level of tumor-infi ltrating lymphocytes (TILs) in primary neoplasm ranged from 4 to 12%, in recurrent tumors it remained low: 5-10%.Conclusion. Given the heterogeneity of BC, the risk of developing LRR depends on many factors. LRR developed in luminal HER2-positive cancer in 9.7% of cases (p 0.05), stage III breast cancer — 4.2% (p 0.05). One of the important predictive factors is the evaluation of TILs. We noted a low level of TILs in both primary and recurrent tumors. There is a high discordance in the receptor status — 72.7%, which is important to take into account when prescribing systemic therapy.
Clinical characteristics and assessment of the frequency of complications after surgical treatment of patients with free and strangulated hernias using synthetic implants
Authors: Lyzikov A. A. , Artyushkov E. L. , Doroshko Ya. Y. , Kaplan M. L.
Published: January 2024

Objective. To give a clinical assessment and conduct a comparative analysis of the frequency of postoperative complications in patients with free and strangulated hernias of various localizations after tension-free hernioplasty using synthetic implants.Materials and methods. A retrospective analysis of 965 medical records of inpatient patients who underwent tension-free hernioplasty for hernias of various localizations in the period from 2018 to 2022 was carried out. The results of the study were processed using applied statistics using MS Excel and a software package for statistical analysis “Statistica v. 10.0”. Statistically significant differences were considered at p < 0.05.Results. The study revealed that in the postoperative period after tension-free hernioplasty in patients with strangulated hernias, the complication rate was 15.8%. At the same time, the frequency of complications was higher after “onlay” hernioplasty in patients with strangulated hernias than in patients with free hernias. The frequency of postoperative complications in patients with impaired postoperative ventral hernias is 8.3 times higher than in patients with free postoperative ventral hernias. In the postoperative period, complications such as seroma and infiltration of the postoperative wound were detected in 10.5 and 5.2% of cases in patients with strangulated hernias. The duration of inpatient treatment for patients with complications after hernioplasty is 2.6 times longer compared to patients without complications (p < 0,05).Conclusion. In the postoperative period, in patients with strangulated hernias, the incidence of complications was observed in 15.8% of cases, and in patients with free and irreducible hernias in 1.5% of cases. Clinically, such postoperative complications as seromas, infiltrates of the postoperative wound, ligature fistulas, scrotal hematoma, orchitis, abscess of the postoperative wound were identified.
Kidney pathology in liver cirrhosis
Authors: Malaeva E. G.
Published: January 2024

Objective. To analyze the structure and frequency of kidney pathology in liver cirrhosis according to sectional analysis and to study the relationship between acute renal injury and urinary tract infection.Materials and methods. The design of the study is mixed: descriptive and analytical, which included conducting a retrospective case–control study of kidney pathology based on the results of the protocols of pathoanatomical autopsies on the basis of the state healthcare institution “Gomel Regional Clinical Pathoanatomical Bureau” for the period of January 2022 – July 2023 and clinical, laboratory, instrumental, cytological, microbiological data of patients with liver cirrhosis. The study included 98 deceased patients, including 70 (71.4%) men, 28 (28.6%) women. The average age was 53.9 years, the majority of patients were persons of working age — 72.9% of men and 60.7% of women, 21.4% were young people.Results. The most common kidney pathology in liver cirrhosis according to sectional analysis is acute renal injury (57.1%). Kidney abscesses (3%), tubulointerstitial nephritis (2%) and pyelonephritis (4%) were less frequently diagnosed. Despite the absence of a history of kidney diseases in most patients with cirrhosis, classical clinical, laboratory and instrumental signs of renal tissue damage, macroscopic and microscopic changes of the kidneys were revealed in 100% of cases at autopsy. In 84.7% of cases, acute tubular necrosis was morphologically diagnosed from focal (51%) to total (19.4%), which was not always accompanied by an increase in serum creatinine levels. A moderate relationship was established between acute kidney injury and urinary tract infection (OR = 14; 95 % CI 11.13–16.61).Conclusion. The most common complication of liver cirrhosis associated with an unfavorable prognosis is acute renal injury, which is associated with the presence of urinary tract infection.
Platelet-associated NETosis in monitoring inflammation in rheumatoid arthritis and systemic lupus erythematosus
Authors: Zubkova Zh. V.
Published: January 2024

Objective. To assess the possibility of using platelet-associated NETosis parameters to monitor inflammatory activity in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).Materials and methods. 50 patients with RA and 29 patients with SLE were examined. The parameters of early and late platelet-associated NETosis were assessed in autologous mixed cultures containing a leukocyte suspension and intact and ADP-stimulated platelets.Results. In patients with RA and SLE in the acute stage, rates of platelet-associated NETosis were increased compared to healthy individuals (p = 0,00001-0,001). During the period of clinical remission, NETosis parameters decreased in comparison with the exacerbation stage (NET-Рst: p=0,017-0,04), in some cases reaching control values. Based on regression analysis, threshold values for platelet-associated NETosis parameters were determined to assess the activity of the inflammatory process in patients with RA and SLE.Conclusion. Parameters of platelet-associated NETosis are informative laboratory markers of the inflammatory process in patients with RA and SLE.
Mechanical and structural properties of rat and human lymphocytes after the exposure of the whole blood to X-rays in vitro
Authors: Chelnokova I. А. , Shkliarava N. M. , Yegorenkov N. I. , Starodubtseva M. N.
Published: January 2024

Objective. By the means of atomic force microscopy to determine the changes in the parameters of the structural and mechanical properties of peripheral blood lymphocytes induced by the irradiation of whole blood by X-rays and identifying the possibility of assessing a state and radiation-induced lymphocyte death programs by analyzing a set of such parameters.Materials and methods. Whole blood of rats and humans was irradiated with X-rays (1–100 Gy) in vitro. Lymphocytes were isolated from the blood after a day of storage, placed on glass slides, fixed with glutaraldehyde and dried. The study of structural and mechanical properties was carried out with the help of atomic force microscope Bruker Bioscope Resolve in Peak Force QNM mode in air. For the sets of AFM parameters, which included elastic modulus, adhesion force, cell surface roughness and cell sizes, a k-mean clustering of data was carried out for the studied experimental groups.Results. The X-ray irradiation of the blood caused changes in the structural and mechanical properties of lymphocytes measured by AFM at the nanoscale. Clustering analysis of the sets of AFM parameters revealed clusters with similar structure in each experimental group (humans, 6and 16-month rats). The studied four clusters were associated with cell states and cell death programs: non-activated cells, activated cells with increased stiffness, apoptotic cells with reduced stiffness, and cells dying via programs other than apoptotic ones with increased stiffness. Each cluster (cell type) with a specific set of AFM parameters was represented differently in the blood lymphocyte population, depending on the dose of X-rays.Conclusion. The set of ACM parameters of lymphocytes including elastic modulus, adhesion force, roughness, and cell sizes, can be helpful for automatically determining the state and death program of lymphocytes after the local irradiation of humans with the involvement of peripheral blood (for example, after radio-therapeutic causes).
Viral hepatitis E in pregnant women in Belarus: clinical examples and molecular genetic characterization of the virus
Authors: Davydov V. V. , Znovets T. V. , Marchuk S. I. , Babenka A. S. , Gasich E. L. , Zhavoronok S. V.
Published: January 2024

Objective. To conduct a clinical and molecular genetic study of two cases of acute hepatitis E in pregnant women from Belarus.Materials and methods. A total of 227 pregnant women with clinical symptoms of liver damage were included in the study. Blood serum samples were used for detection of antibodies to hepatitis E virus by enzyme-linked immunosorbent assay, virus nucleic acid was detected from fecal samples by reverse transcription nested polymerase chain reaction. The nucleotide sequence was determined on an automated sequencer using the Sanger method. Nucleotide sequences were analyzed, genotyped and evolutionary distances calculated using MEGA X software.Results. Out of 227 sera tested, immunoglobulins of class G to hepatitis E virus were detected in 15, which is 6.61%. M immunoglobulins were also detected in the blood of six pregnant women, which is 2.6%. Two clinically evident cases of acute hepatitis E were identified. One of the two patients ended her pregnancy with antenatal fetal death. Virus nucleic acid was isolated from another woman diagnosed with hepatitis E, who had an episode of nutritional contact with raw minced pork. The virus RNA sequence isolated from this patient’s body is clustered into a common phylogenetic branch with the sequence obtained from the body of a patient from Belarus with a history of kidney transplantation and sequences isolated from the body of a domestic pig in the Republic of Belarus.Conclusion. Hepatitis E virus poses a significant threat to pregnant women. A set of preventive measures against hepatitis E in pregnant women has been proposed.
Analysis of the effectiveness of COVID-19 coronavirus vaccination in patients with chronic heart failure at the outpatient stage of treatment
Authors: Sharoiko V. А. , Stoma I. О. , Kovalev A. A. , Yarmolenko V. A.
Published: January 2024

Objective. To analyze the dynamics of COVID-19 coronavirus infection incidence in patients with chronic heart failure (CHF) on the background of vaccination against SARS-CoV-2 virus, to evaluate the role of vaccination in preventing decompensation of chronic heart failure, reducing mortality, primary disability in patients with cardiovascular diseases complicated by CHF.Materials and methods. The study included 200 people who were included in the Register of patients with CHF of the State Healthcare Institution “Gomel City Clinical Polyclinic No. 5 named after S. V. Golukhova”. Patients were divided into two equal in number groups: Group 1 unvaccinated against COVID-19 coronavirus infection (n = 100) and Group 2 vaccinated patients (n = 100). The follow-up was conducted for one year (2021) in an outpatient setting.Results. The incidence rate in the group of unvaccinated patients was 3.2 times higher. The incidences of COVID-19 coronavirus infection in the two groups were 16 (16 %) and 5 (5 %), respectively (χ2 = 5.32, p = 0.0210). The incidence of hospitalization for decompensation of CHF was 3.2 times higher in the unvaccinated group than in the vaccinated group (χ2 = 14.93, p = 0.0001). Lethality among the unvaccinated was recorded 1.8 times higher than in the vaccinated group (χ2 = 2.166, p = 0.1410). When comparing the rates of primary disability due to CVD, there was a tendency for increased disability in the unvaccinated cohort (χ2 = 0.592, p = 0.4420).Conclusion. It has been established that vvaccination contributes to the reduction of hospitalization for decompensation of CHF, reducing the risk of mortality.
The role of medical and organizational measures in improving the quality of early detection and clinical examination of autoimmune thyroiditis among the population of the Republic of Belarus
Authors: Danilova L. I. , Rozhko V. A. , Veyalkin I. V. , Nikanovich S. N. , Sharshakova T. M.
Published: January 2024

Objective. To evaluate the role of medical and organizational measures in improving the quality of early detection and medical examination of autoimmune thyroiditis in the population of the Republic of Belarus.Materials and methods. The data of population statistics and the State register of persons affected by the Chernobyl catastrophe and other accidents on cases of thyroid pathology, as well as outpatient records of patients were analyzed. Epidemiological, statistical and sociological methods were used.Results. It was noted that different clinical and laboratory variants of autoimmune thyroiditis (AIT) are encountered in clinical practice. Subclinical AIT with sonographic signs of the disease but without diagnostic concentrations of antibodies to thyroid peroxidase (AB/TPO) and disturbances of its function is registered in 14.1 (6.0-24.4) %. AIT with diagnostic concentrations of autoantibodies to AB/TPO, with preserved thyroid function or hypothyroidism occurs in 22.5 (13.534.0) % of the cohort subjects. The frequency of combining AIT with nodular neoplasms of the thyroid increased by the 4th stage of screening and reached 20.7 (11.2-33.4) %.The reasons for different approaches to diagnosis were analyzed and measures to improve organizational and medical measures for early detection and dispensary treatment of patients with AIT were proposed: groups of persons at high risk of AIT and primary hypothyroidism (PHT) were identified, an algorithm for early detection and dispensary treatment was developed, etc.Conclusion. When making a decision to improve the quality of medical care to the population of the Republic of Belarus on early detection and medical examination of patients with AIT, it is necessary to take into account the timeliness of thyroid status studies in the population, compliance with the terms of dynamic observation for persons at high risk of AIT and PHT development, peculiarities of clinical and laboratory variants of AIT course.
Features of medical university students’ professional value orientations
Authors: Gapanovich-Kaidalov N. V. , Sharshakova T. M.
Published: January 2024

Objective. To identify the features of medical university students’ professional value orientations.Material and methods. Methods of theoretical analysis of philosophical, psychological and pedagogical literature on the research problem were used; G. E. Leevik’s questionnaire “Value orientations of personality 8” (VOP-8); methods of statistical analysis of empirical data (generalization and grouping of data, Spearman’s rank correlation method).Results. The analysis of professional value orientations of junior medical university students showed that the participants of the study are characterized, first of all, by such value orientations as labor and material values, the desire to be financially secure, a good specialist, to have a vast professional experience, to improve themselves in the profession. At the same time, there is an underestimation of the importance of moral and moral qualities of effective professional communication of a doctor.Conclusion. To ensure high quality of professional medical education it is important to form in students value orientations and professionally important qualities, which are necessary for successful professional activity and effective communication with patients, their relatives, colleagues and administration of medical institution.
Yersiniosis with fever of unclear genesis
Authors: Kadochkina N. G. , Salivontchik A. P. , Mitsura V. M. , Pronevich A. V.
Published: January 2024

The article presents a clinical case of yersiniosis with fever of unclear genesis. For early diagnosis of yersiniosis, its adequate therapy and prevention of complications, it is necessary to take into account the dynamics of clinical manifes- tations and timely conduct specific diagnosis of the disease. Late diagnosis may be associated with the lack of vigilance of doctors with regard to this infection.
Determination of Helicobacter pylori primary resistance to levofloxacin in gastric mucosal biopsy samples using real-time polymerase chain reaction
Authors: Voropaeva A. V. , Shevchenko N. I.
Published: January 2024

Objective. To study the primary resistance of Helicobacter pylori (H. pylori) to levofloxacin in residents of Gomel region by real-time polymerase chain reaction (RT PCR).Materials and methods. The study included 170 patients diagnosed with gastritis and duodenitis, K29, median age - years (25% and 75% 37 and 61 years). According to the questionnaire data of the patients, eradication therapy with levofloxacin was not performed for them. To determine the resistance of H. pylori to levofloxacin we used RT PCR. Results. Out of 170 DNA samples analyzed, 8 samples had doubtful results and according to the methodology for recording the results are subject to rearrangement from the DNA isolation stage. The remaining 162 samples were positive for the β-actin gene (internal control sample ICS) and were taken into account in further analysis (Ct, CY5 19.6-27.4). 16sRNA gene DNA (Ct, ROX 19.5-30.04), indicative of bacterial infection, was confirmed in 152 samples (93.8%). DNA of the gyrA gene (point mutations A259T, T261C, G261A, G271A, G271T and A272G) was detected in 19 of 152 DNA samples, and H. pylori resistance to levofloxacin was 12.5 %, (Ct, Hex 23.2-30.7). The positive control samples had characteristic curve growth on the corresponding detection channels, while the negative samples showed no curve growth.Conclusion. Primary resistance of H. pylori to levofloxacin in residents of Gomel region amounted to 12.5%. Mutations of gyrA gene are the most sensitive marker for predicting successful eradication when using fluoroquinolones, in particular levofloxacin. RT PCR is a reliable method of mutation detection and allows simultaneous detection of H. pylori DNA and resistance to levofloxacin, which significantly reduces the study time.
Post-process correction improves the accuracy of satellite PM2.5 retrievals
Authors: Porcheddu Andrea , Kolehmainen Ville , Lähivaara Timo , Lipponen Antti
Published: January 2024

Abstract. Estimates of PM2.5 levels are crucial for monitoring air quality and studying the epidemiological impact of air quality on the population. Currently, the most precise measurements of PM2.5 are obtained from ground stations, resulting in limited spatial coverage. In this study, we consider satellite-based PM2.5 retrieval, which involves conversion of high-resolution satellite retrieval of Aerosol Optical Depth (AOD) into high-resolution PM2.5 retrieval. To improve the accuracy of the AOD to PM2.5 conversion, we employ the machine learning based post-process correction to correct the AOD-to-PM conversion ratio derived from Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA-2) reanalysis model data. The post-process correction approach utilizes a fusion and downscaling of satellite observation and retrieval data, MERRA-2 reanalysis data, various high resolution geographical indicators, meteorological data and ground station observations for learning a predictor for the approximation error in the AOD to PM2.5 conversion ratio. The corrected conversion ratio is then applied to estimate PM2.5 levels given the high-resolution satellite AOD retrieval data derived from Sentinel-3 observations. Our model produces PM2.5 estimates with a spatial resolution of 100 meters at satellite overpass times. Additionally, we have incorporated an ensemble of neural networks to provide error envelopes for machine learning related uncertainty in the PM2.5 estimates.
Deciphering anthropogenic and biogenic contributions to selected NMVOC emissions in an urban area
Authors: Peron Arianna , Graus Martin , Striednig Marcus , Lamprecht Christian , Wohlfahrt Georg , Karl Thomas
Published: January 2024

Abstract. The anthropogenic and biogenic contributions of isoprene, monoterpenes, sesquiterpenes and methanol in an urban area were estimated based on direct eddy covariance flux observations during four campaigns between 2018 and 2021. While these compounds are typically thought to be dominated by biogenic sources on regional and global scales, the role of potentially significant anthropogenic emissions in urban areas has been recently debated. Typical fluxes of isoprene, monoterpenes and sesquiterpenes were on the order of 0.09 nmol m−2 s−1, 0.09 nmol m−2 s−1 and 0.003 nmol m−2 s−1 during spring. During summer, emission fluxes of isoprene, monoterpenes and sesquiterpenes were higher on the order of 0.85 nmol m−2 s−1, 0.11 nmol m−2 s−1, 0.004 nmol m−2 s−1. It was found that the contribution of the anthropogenic part is strongly seasonally dependent. For isoprene the anthropogenic fraction can be as high as 64 % in spring, but is typically very low < 18 % during the summer season. For monoterpenes the anthropogenic fraction was estimated between 43 % in spring and less than 20 % in summer. With values of 2.8 nmol m−2 s−1 in spring and 3.2 nmol m−2 s−1 in summer, methanol did not exhibit a significant seasonal variation of observed surface fluxes. However, there was a difference in emissions between weekdays and weekends (about 2.3 times higher on weekdays in spring). This suggests that methanol emissions are likely influenced by anthropogenic activities during all seasons.
Brief communication: A technique for making in situ measurements at the ice–water boundary of small pieces of floating glacier ice
Authors: Johnson Hayden A. , Glowacki Oskar , Deane Grant B. , Stokes M. Dale
Published: January 2024

Abstract. This paper presents an apparatus and associated methods for making direct in situ measurements of the ice–water boundary of small pieces of floating glacier ice. The method involves approaching ice pieces in a small boat and attaching a frame with instruments on it to them using ice screws. These types of measurements provide an opportunity to study small-scale processes at the ice–water interface which control heat flux across the boundary. Recent studies have suggested that current parameterizations of these processes may be performing poorly. Improving understanding of these processes may allow for more accurate theoretical and model descriptions of submarine melting.
Modeled variations in the inherent optical properties of summer Arctic ice and their effects on the radiation budget: a case based on ice cores from 2008 to 2016
Authors: Yu Miao , Lu Peng , Leppäranta Matti , Cheng Bin , Lei Ruibo , Li Bingrui , Wang Qingkai , Li Zhijun
Published: January 2024

Abstract. Variations in Arctic sea ice are apparent not only in its extent and thickness but also in its internal properties under global warming. The microstructure of summer Arctic sea ice changes due to varying external forces, ice age, and extended melting seasons, which affect its optical properties. Sea ice cores sampled in the Pacific sector of the Arctic obtained by the Chinese National Arctic Research Expedition (CHINARE) during the summers of 2008 to 2016 were used to estimate the variations in the microstructures and inherent optical properties (IOPs) of ice and determine the radiation budget of sea ice based on a radiative transfer model. The variations in the volume fraction of gas bubbles (Va) of the ice top layer were not significant, and the Va of the ice interior layer was significant. Compared with 2008, the mean Va of interior ice in 2016 decreased by 9.1 %. Meanwhile, the volume fraction of brine pockets increased clearly during 2008–2016. The changing microstructure resulted in the scattering coefficient of the interior ice decreasing by 38.4 % from 2008 to 2016, while no clear variations can be seen in the scattering coefficient of the ice top layer. These estimated ice IOPs fell within the range of other observations. Furthermore, we found that variations in interior ice were significantly related to the interannual changes in ice ages. At the Arctic basin scale, the changing IOPs of interior ice greatly changed the amount of solar radiation transmitted to the upper ocean even when a constant ice thickness is assumed, especially for thin ice in marginal zones, implying the presence of different sea ice bottom melt processes. These findings revealed the important role of the changing microstructure and IOPs of ice in affecting the radiation transfer of Arctic sea ice.
ON THE ISSUE OF SOCIAL ENTREPRENEURSHIP
Authors: НОВИЦКАЯ Л.Ю.
Published: January 2024

В статье проанализированы как иностранные, так и российские научные исследования по теме «социальное предпринимательство», определено его значение для страны и развития национальной эконо- мики. Автор пришел к выводу о том, что социальное предпринимательство призвано обеспечить поддержку уязвимых слоев населения, предоставляя возможность трудоустройства все большему количеству людей, что является основой как для развития самого бизнеса в частности, так и для последующего расширения произ- водства и сопутствующей полезной инфраструктуры в целом.

The author in the article analyzed both foreign and Russian scientific research on the topic of «social entrepreneurship», determined its importance for the country and the development of the national economy. The author came to the conclusion that social entrepreneurship is designed to provide support to vulnerable segments of the population, providing employment opportunities to an increasing number of people, which is the basis for both the development of the business itself in particular, and the subsequent expansion of production and related useful infrastructure in general.
ESTABLISHING A PERIOD OF PROBATION FOR ADVOCATES IN ORDER TO MINIMIZE THE RISK OF PROVIDING UNQUALIFIED LEGAL ASSISTANCE TO CLIENTS
Authors: МАРЧЕВА П.Е.
Published: January 2024

В статье автор обращает внимание на необходимость внесения изменений в механизм всту- пления в адвокатуру, существующий в настоящее время. Существующий механизм сдачи квалификационного экзамена не исключает риск попадания в адвокатскую корпорацию тех, чьи личные качества и индивидуально- психологические особенности не соответствуют выбранной профессиональной деятельности, что может при- вести к профессиональным деструкциям и, как следствие, невозможности предоставлять квалифицированную юридическую помощь доверителям.

In the article, the author draws attention to the necessity to amend the current mechanism of admission to the Bar. The actual mechanism does not exclude the of admission to the Bar of those whose personal qualities and individual psychological characteristics do not correspond to the chosen professional activity, which can ultimately lead to occupational destruction and, as a result, to inability to provide qualified legal assistance to clients.
ZEROING OUT THE DEADLINES FOR A TAX AUDIT: A CONSTITUTIONAL AND LEGAL TEST
Authors: СУЛТАНОВ А.Р.
Published: January 2024

В статье рассмотрена проблема исчисления сроков в налоговых правоотношениях на примере кейса, дошедшего до Конституционного Суда РФ. Автор полагает, что правовые позиции Конституционного Суда, рассматривавшего срок, в качестве, с одной стороны, гарантии прав налогоплательщика, а с другой – пределов допускаемого законом ограничения его прав, имеют более широкое значение, чем мотивировка для конкретной правовой проблемы.

This article discusses the problem of calculating deadlines in tax relations. The problem is considered on the example of a case that reached the Constitutional Court of the Russian Federation. The author believes that the legal positions of the Constitutional Court, which considered the term as, on the one hand, a guarantee of the taxpayer's rights, and on the other, the limits of the restriction of his rights allowed by law, have a broader meaning than the motivation for a specific legal problem.
CERTAIN ASPECTS OF PROTECTING CREDITOR'S RIGHTS IN PROCESS OF ADOPTION OF THE EXTERNAL ADMINISTRATION PLAN
Authors: МИХАЙЛОВ Д.Ю.
Published: January 2024

Статья посвящена особенностям защиты прав кредитов в процедуре внешнего управления, связанным с утверждением плана внешнего управления. Проанализирован вопрос о соотношении полномочий собрания кредиторов, суда и должника при утверждении плана. Сделан вывод о приоритете решения общего собрания кредиторов перед иными участниками дела о банкротстве в вопросе утверждения плана внешнего управления.

The article is devoted to the peculiarities of the protection of the rights of creditors in process of adoption of the external administration plan during external administration procedure. The issue of the relationship between the powers of the creditors’ meeting, the court and the debtor in process of adoption is analyzed. The author concluded that the decision of the creditors’ meeting has priority over other participants of bankruptcy proceeding.
The Acute Effect of Percussive Massage Intervention with and without Heat Application on Plantar Flexor Muscles’ Passive and Active Properties
Authors: Nakamura Masatoshi , Uchida Hironori , Murakami Yuta , Kasahara Kazuki , Imai Takaki , Konrad Andreas
Published: January 2024

Recently, percussive massage (PM) intervention using a handheld percussive massage device, namely a massage gun, has been used as an easy way to perform vibration functions. Additionally, a product has been developed that allows PM intervention and heat application to be performed simultaneously. Thus, this study aimed to compare the acute effects of PM intervention with and without heat application on dorsiflexion (DF) range of motion (ROM), passive stiffness, and muscle strength in the gastrocnemius muscle. Fifteen healthy young men (20.9 ± 0.2 years) participated in this study. We measured the DF ROM, passive torque at DF ROM (an indicator of stretch tolerance), passive stiffness, and maximum voluntary isometric contraction (MVIC) torque of the plantar flexor muscles before and immediately after 120 seconds PM intervention with and without heat application. The results showed that PM intervention with and without heat application significantly increased DF ROM and passive torque at DF ROM and decreased passive stiffness, not MVIC torque. These results suggest that PM intervention increased ROM and decreased passive stiffness regardless of the presence or absence of the heat application.
Criterion-Related Validity of Consumer-Wearable Activity Trackers for Estimating Steps in Primary Schoolchildren under Controlled Conditions: Fit-Person Study
Authors: Mayorga-Vega Daniel , Casado-Robles Carolina , Guijarro-Romero Santiago , Viciana Jesús
Published: January 2024

The purposes were to examine the criterion-related validity of the steps estimated by consumer-wearable activity trackers (wrist-worn activity trackers: Fitbit Ace 2, Garmin Vivofit Jr, and Xiomi Mi Band 5; smartphone applications: Pedometer, Pedometer Pacer Health, and Google Fit/Apple Health) and their comparability in primary schoolchildren under controlled conditions. An initial sample of 66 primary schoolchildren (final sample = 56; 46.4% females), aged 9-12 years old (mean = 10.4 ± 1.0 years), wore three wrist-worn activity trackers (Fitbit Ace 2, Garmin Vivofit Jr 2, and Xiaomi Mi Band 5) on their non-dominant wrist and had three applications in two smartphones (Pedometer, Pedometer Pacer Health, and Google Fit/Apple Health for Android/iOS installed in Samsung Galaxy S20+/iPhone 11 Pro Max) in simulated front trouser pockets. Primary schoolchildren’s steps estimated by the consumer-wearable activity trackers and the video-based counting independently by two researchers (gold standard) were recorded while they performed a 200-meter course in slow, normal and brisk pace walking, and running conditions. Results showed that the criterion-related validity of the step scores estimated by the three Samsung applications and the Garmin Vivofit Jr 2 were good-excellent in the four walking/running conditions (e.g., MAPE = 0.6-2.3%; lower 95% CI of the ICC = 0.81-0.99), as well as being comparable. However, the Apple applications, Fitbit Ace 2, and Xiaomi Mi Band 5 showed poor criterion-related validity and comparability on some walking/running conditions (e.g., lower 95% CI of the ICC < 0.70). Although, as in real life primary schoolchildren also place their smartphones in other parts (e.g., schoolbags, hands or even somewhere away from the body), the criterion-related validity of the Garmin Vivofit Jr 2 potentially would be considerably higher than that of the Samsung applications. The findings of the present study highlight the potential of the Garmin Vivofit Jr 2 for monitoring primary schoolchildren’s steps under controlled conditions.
La Modernidad en escorzo. Nota crítica de Adrián Almazán Gómez, Adrián (2021). Técnica y tecnología. Cómo conversar con un tecnolófilo. Taugenit.
Authors: Santamaría Pérez Adrián , Pinto Freyre Jesús
Published: January 2024

El recientemente publicado libro de Adrián Almazán Gómez, Técnica y tecnología. Cómo conversar con un tecnolófilo, constituye un intento de aprender del pasado para auspiciar un futuro que supere la crisis de encaje entre tecnosfera y biosfera en que consiste nuestro presente. El planteamiento en el libro de figuras como el campesino y el artesano, así como de una marcada oposición entre naturaleza y ciencia, invita a un debate y a una profunda indagación que problematice la Modernidad.
Revolución educativa y teoría político-pedagógica en Paulo Freire
Authors: Morollón del Río Diego
Published: January 2024

Paulo Freire ha sido reconocido como uno de los pedagogos más importantes del siglo XX, sin embargo, su obra va más allá de la pedagogía en diversos aspectos. La vinculación de sus textos con situaciones políticas de transición o de transformación en diversos lugares del mundo como Pernambuco, Brasil o Guinea-Bisáu, antigua colonia de Portugal en África, nos hacen notar una transversalidad de su teoría que bascula hacia la filosofía política y la sociología. En este artículo se constata cómo en las obras de Paulo Freire redactadas como procesos político-pedagógicos y biográficos, se encuentra un esquema organizacional del poder y de la participación de las poblaciones en las tomas de decisión frente a problemáticas sociales. Para ello se partirá de su circunstancia en Brasil, como mapa donde incardinar la obra de Freire, y de ahí se pasará a la teorización de uno de sus textos más visibles como es Pedagogía del Oprimido. En esta obra, fruto de tales circunstancias, nuestro autor establece un paralelismo entre la teoría educativa y la política. En ella también encontramos una reflexión sobre sujetos que renuevan premisas de la teoría tradicional política y que establecen el campo de aprendizaje de nuevo en forma de dialéctica.