bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of polymorphism of human genes, orthologues of which are functionally involved in the response to experimental brain ischemia in model systems
Authors: Хрунин А.В. , Хворых Г.В. , Гнатко Е.Д. , Филиппенков И.Б. , Ставчанский В.В. , Дергунова Л.В. , Лимборская С.А.
Published: November 2020

В условиях модели экспериментальной ишемии мозга крыс, вызванной обратимой окклюзией правой средней мозговой артерии, с использованием методов RNA-Seq и ПЦР в реальном времени были выявлены гены, значительно меняющие свою активность в мозге крыс. Для 38 наиболее активных генов были определены гены-ортологи у человека. С использованием баз данных проекта 1000 геномов (популяция CEU) был изучен полиморфизм каждого из генов и отобраны локусы, которые демонстрировали максимальное число ассоциаций с другими полиморфизмами (tagSNPs). На первом этапе был исследован полиморфизм генов DRD2, CCL23, SOCS3, HSPB1 и CHRM4, в каждом из которых были идентифицированы от одного до трех tagSNPs. С использованием метода ПЦР в режиме реального времени (TaqMan) аллельные варианты отобранных локусов были генотипированы в выборке больных ишемическим инсультом (100 чел.) и контрольной группе (100 чел.). Частоты встречаемости генотипов исследованных полиморфизмов в контрольной группе, в большинстве случаев, оказались близкими таковым в группе больных с ишемическим инсультом. Наиболее существенные различия в распределении генотипов между выборками (p = 0,088) были продемонстрированы для локуса rs8069976 из региона локализации гена SOCS3. Для уточнения направленности выявленных различий планируется их проверка на выборках больных и контроля больших размеров.

In a model of experimental rat brain ischemia caused by the right transient middle cerebral artery occlusion using RNA-Seq and real-time PCR, genes that significantly change their activity in the rat brain were revealed. For 38 most active rat genes their human orthologous genes were identified. Using the genotype data from the 1000 genome project (CEU population), we explored the polymorphism of each of the genes and identified the loci showed the maximum number of associations with other polymorphisms (tagSNPs). At the first stage, the polymorphisms in DRD2, CCL23, SOCS3, HSPB1 and CHRM genes were studied. From one to three tagSNPs were selected for further analysis in each gene. Using TaqMan real-time PCR assays, allelic variants of the selected loci were genotyped in 100 patients with ischemic stroke and in 100 controls. In the most cases the frequencies of genotypes of the SNPs in the control group were similar to those in the group of patients with ischemic stroke. The most substantial differences in the distribution of genotypes between the groups (p = 0.088) were demonstrated for the SNP rs8069976 from the region of SOCS3 gene. To clarify the direction of the differences revealed, their testing in the patient and control samples of larger sizes is planned.
Analysis of polymorphism of SNP markers of genes involved in nonshivering thermogenesis, UCP1 (rs1800592), UCP2 (rs659366) and UCP3 (rs2075577) in Yakuts and Chukchi
Authors: Никанорова А.А. , Барашков Н.А. , Дьяконов Е.Е. , Находкин С.С. , Пшенникова В.Г. , Соловьев А.В. , Кузьмина С.С. , Сазонов Н.Н. , Бурцева Т.Е. , Федорова С.А.
Published: November 2020

Впервые был проведен анализ частот аллелей полиморфизмов генов UCP1 (rs1800592), UCP2 (rs659366) и UCP3 (rs2075577) в популяциях якутов и чукчей, проживающих в условиях экстремального климата Восточной Сибири.

For the first time an analysis of the frequencies of alleles polymorphism of the genes UCP1 (rs1800592), UCP2 (rs659366) and UCP3 (rs2075577) were studied in the Yakut and Chukchi populations, living in the extreme climate of Eastern Siberia.
Genes of DNA repair proteins and lifetime
Authors: Бабушкина Н.П. , Постригань А.Е. , Кучер А.Н.
Published: November 2020

Гены белков репарации ДНК интересны с точки зрения их роли в формировании многофакторных заболеваний. Нами изучена изменчивость 8 SNP в 6 генах белков репарации ДНК в разных возрастных когортах жителей г. Томска. Для rs473297 в гене MRE11 выявлены возраст-зависимые изменения частот аллелей и генотипов: для старшей возрастной когорты зарегистрированы различия по частотам аллелей и генотипов как с младшей когортой (p=0,04 и p=0,047 соответственно), так и с долгожителями (p=0,02 и p=0,047 соответственно). Аллель T rs473297 ассоциирован, с одной стороны, с долгожительством (p=0,02 за счет генотипов TT и GT), с другой - со смертностью от сердечно-сосудистых заболеваний в возрасте до 55 лет (только генотипы TT, p=0,03). То есть, rs473297 в гене MRE11 может быть вовлечен в определение продолжительности жизни через селективную выживаемость носителей разных генотипов, больных сложно-наследуемыми заболеваниями.

Genes of DNA repair proteins are interesting from the point of view of involvement of formation of common diseases. We studied variability of 8 SNP in the six DNA repair proteins genes in different age cohorts of residents of Tomsk. For rs473297 (MRE11), age-dependent changes alleles and genotypes frequencies were identified: for the older age cohort of the population sample, differences in alleles and genotypes frequencies were recorded with both the younger cohort (p=0.04 and p=0.047, respectively) and long-livers (p=0.02 and p=0.047, respectively). Allele T rs473297 is associated, on the one hand - with longevity (p=0.02, due to genotypes TT and GT), on the other - with mortality from cardiac death under 55 years of age (only homozygotes TT, p=0.03). That is, rs473297 (MRE11) may be involved in determining lifetime through selective survival of carriers of different genotypes suffering from common diseases.
Expression of FN1 and PDGFRβ in lymph nodes metastasis of breast cancer
Authors: Гришина К.А. , Поспехова Н.И. , Хайленко В.А. , Карпухин А.В.
Published: November 2020

Наиболее серьёзным осложнением рака молочной железы (РМЖ) является метастазирование опухоли, что является причиной более 80% всех случаев смерти от РМЖ. Процесс раннего метастазирования в лимфатические узлы изучен недостаточно. Нами были изучены 47 парных образцов ткани молочной железы. Все больные не подвергались воздействию лучевой терапии и химиотерапии. Найдена ассоциация экспрессии генов FN1 и PDGFRβ с риском раннего метастазирования (р = 0,012 и 0,03, соответственно). Относительный риск (ОР) составил для FN1 ОР = 1,5, 95% ДИ 1,1-1,9, для PDGFRβ ОР = 2,4, 95% ДИ 1,1-5,2.

The most serious complication of breast cancer (BC) is metastasis, which causes more than 80% of all deaths from BC. The process of lymph nodes metastasis is not well understood. 47 paired frozen breast tissue samples were collected. All patients have no radiation therapy and chemotherapy. We studied the expression of two genes - FN1 and PDGFRβ - for the investigation of their relationship to lymph nodes metastasis. Expression of the FN1 and PDGFRβ genes showed an association with the risk of early metastasis (p = 0.012 and 0.03, correspondently). The relative risk (RR) for FN1 was RR = 1.5, 95% CI 1,1-1,9, and for PDGFRβ RR = 2.4, 95% CI 1,1-5,2.
Methylation of the genes encoding extracellular matrix proteins and transmembrane receptors in breast cancer
Authors: Симонова О.А. , Кузнецова Е.Б. , Танас А.С. , Руденко В.В. , Кекеева Т.В. , Немцова М.В. , Залетаев Д.В. , Стрельников В.В.
Published: November 2020

Для понимания особенностей регуляции и механизмов взаимодействия белков матрикса и трансмембранных рецепторов и их роли в поддержании структуры и функции ткани молочной железы в норме и при канцерогенезе важно установить вклад изменений экспрессии этих белков в процессы развития, роста, инвазии и метастазирования опухолей. Изучение статуса метилирования генов, кодирующих белки ламининов, нидогенов, интегринов, кадгеринов, матриксных металлопротеиназ и их ингибиторов в нормальной и опухолевой ткани необходимо для установления роли этих генов и механизмов их регуляции при раке молочной железы. Нами проведено исследование состояние метилирования этих генов в нормальных и опухолевых тканях молочной железы с целью поиска эпигенетических маркеров, ассоциированных с клинико-морфологическими характеристиками опухолей.

To understand mechanisms of interaction between extracellular matrix proteins and transmembrane receptors, as well as their role in maintaining the structure and function of breast tissue in norm and in cancer, an important issue is to determine the contribution of changes in the expression of these proteins to the processes of development, growth, invasion and metastasis of breast cancer. Studies of the methylation status of genes encoding laminins, nidogens, integrins, cadherins, matrix metalloproteinases and their inhibitors in normal and tumor tissues are necessary to determine the roles of these genes and the mechanisms of their regulation in cancer. We have studied methylation status of these genes in normal and tumor tissues of the mammary gland in order to search for epigenetic markers associated with the clinical and morphological characteristics of the tumors.
Single-nucleotide polymorphisms of the ATM gene, which form a predisposition to breast and ovarian cancer in a population sample of the Chechen Republic
Authors: Бисултанова З.И. , Джамбетова П.М.
Published: November 2020

Были изучены два критических полиморфизма гена ATM, (rs664143 (A>G) и rs189037 (G> A) в выборке из 214 пациентов с раком молочной железы (РМЖ) и раком яичников (РЯ) и 389 женщин контрольной группы (≤45 лет), относящихся к чеченской популяции. Генотипирование выполнено методом ПЦР-анализа. Анализ сопряженности аллельных вариантов гена ATM c риском развития РМЖ и РЯ показал повышенный риск развития РЯ в случае носительства аллеля G полиморфизма rs189037, однако с РМЖ достоверных ассоциаций не выявлено.

Two critical polymorphisms of the ATM gene, (rs664143 (A> G) and rs189037 (G> A), were studied in a sample of 214 patients with breast cancer and ovarian cancer and 389 women in the control group (≤45 years old) belonging to the Chechen population. An analysis of the conjugation of allelic variants of the ATM gene with a risk of developing breast and ovarian cancer showed an increased risk of developing ovarian cancer in case of carriage of the G allele polymorphism rs189037, but no reliable associations were found with breast cancer).
The role of the rs757210 polymorphic variant in the HNF1B gene in the pathogenesis of ovarian cancer
Authors: Мингажева Э.Т. , Ефимова А.В. , Валова Я.В. , Нургалиева А.Х. , Прокофьева Д.С. , Фаисханова Р.Р. , Хуснутдинова Э.К.
Published: November 2020

Рак яичников является одним из наиболее распространенных злокачественных новообразований органов репродуктивной системы. В настоящей работе представлен анализ ассоциации rs757210 гена HNF1B с риском развития РЯ у женщин из Республики Башкортостан.

Ovarian cancer (OC) is one of the most common malignant neoplasms of the organs of the reproductive system. In this paper, we analyze the associations of polymorphisms rs757210 в of the HNF1B gene with the risk of developing OC in women from the Republic of Bashkortostan.
Polymorphisms in the cytochrome P450 CYP1A1, CYP1A2, CYP1B1 genes and risk of colorectal cancer in a population from Central Russia
Authors: Москалев А.С. , Подольский Ф.В. , Зайцев С.М. , Новикова Е.А. , Полоников А.В. , Станоевич У.С. , Бушуева О.Ю.
Published: November 2020

В исследование были включены 256 пациентов с колоректальным раком (134 мужчины, 122 женщины) и 608 практически здоровых добровольцев (279 мужчин, 329 женщин). Генотипирование однонуклеотидных полиморфизмов I462V (rs1048943) CYP1A1, -154A>C (rs762551) CYP1A2 и L432V (rs1056836) CYP1B1 было проведено методом ПЦР в режиме реального времени. Полиморфизм rs1056836 CYP1B1 (замена L432V) ассоциировался с повышенным риском колоректального рака в популяции Центральной России: OR=1,48, 95%CI=1,07-2,04; р=0,02.

A total of 256 patients with colorectal cancer (134 males, 122 females) and 608 age- and sex-matched healthy controls (279 males, 329 females) were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) I462V (rs1048943) CYP1A1, -154A>C (rs762551) CYP1A2 and L432V (rs1056836) CYP1B1 were done using Taq-Man-based assays. Polymorphism rs1056836 (substitution L432V) CYP1B1 was associated with increased risk of colorectal cancer in the population from Central Russia: OR=1,48, 95%CI=1,07-2,04; p=0,02.
Associations genetic polymorphism of xenobiotic biotransformation enzymes and risk of lung adenocarcinoma
Authors: Баканова М.Л. , Минина В.И. , Савченко Я.А. , Глушков А.Н.
Published: November 2020

Обследовано 670 жителей Кемеровской области: 304 человека, первично обратившиеся для диагностики и лечения в Кемеровский областной онкологический диспансер (диагноз аденокарцинома легкого (АКЛ)) и 366 человек - здоровые доноры Кемеровского областного центра крови, которые составили группу сравнения. Цель: анализ генов ферментов биотрансформации ксенобиотиков у больных АКЛ и индивидов, не имеющих онкологических заболеваний, проживающих в той же местности. Исследование полиморфных вариантов генов CYP1A1 (rs4646903Т>С), CYP1A2 (rs762551-163 C>A), GSTM1 (del), GSTT1 (del) осуществляли методом real-time ПЦР (ООО «СибДНК», г. Новосибирск). Стaтистическaя обрaботкa мaтериaлa проводилaсь с использовaнием программ: SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). Выявлены ассоциации АКЛ с генотипом ТС гена CYP1A1 (rs4646903Т>С) и делецией гена GSTТ1(del).

In the presented “case-control” study 670 residents of the Kemerovo Region subject to age, sex, ethnicity and smoking status were included. We formed two groups: 1) “Case” - 304 newly diagnosed lung adenocarcinoma patients undergoing a medical treatment in the Kemerovo Regional Oncology Center; 2) “Control” - 366 healthy donors of the Kemerovo Regional Center of Blood Transfusion. Statistical analysis were performed using SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). A significant association obtained between the CYP1A1 (rs4646903Т>С), GSTТ1(del) and lung adenocarcinoma.
Mutations in the ARID1A and SMARCA4 genes in relapses of Diffuse Large B-cell Lymphoma with CNS damage
Authors: Воропаева Е.Н. , Поспелова Т.И. , Максимов В.Н. , Березина О.В. , Карпова В.С. , Рзаев Д.А. , Колесникова М.А. , Вяткин Ю.В. , Штокало Д.Н. , Баширзаде К.А. , Иванова А.А. , Мельникова Е.С. , Гуражева А.А.
Published: November 2020

Проанализированы данные полногеномного секвенирования более 1200 образцов пациентов с диффузной В-крупноклеточной лимфомой (ДВККЛ) базы CBioPortal for Cancer Genomics. Также выполнено собственное полноэкзомное секвенирование 7 образцов ДВККЛ с рецидивами в ЦНС. Выделены характеристики, ассоциированные с высоким риском вторичного вовлечения ЦНС при лимфоме. Значимые различия в частоте мутаций между подвыборками с поражением ЦНС в рецидиве и без вовлечения ЦНС были получены по генам BCR/NF-kВ пути (MYD88, CD79B) и системы ремоделирования хроматина (ARID1A, SMARCA4).

The genome-wide sequencing data of more than 1200 Diffuse Large B-cell Lymphomas (DLBCL) samples of the CBioPortal database for Genomic cancer were analyzed. We also performed our own full-exome sequencing of 7 samples of DLBCL with relapses in the central nervous system (CNS). Characteristics associated with a high level of secondary CNS involvement in lymphoma were selected. Differences were obtained in the BCR/NF-kB genotypes (MYD88, CD79B) and chromatin remodeling system (ARID1A, SMARCA4).
¿La era de los Códigos o la era de los Restatements? Reflexiones sobre la vigencia del Código como modelo legislativo
Authors: Vega Mere Yuri
Published: November 2020

No son pocas las apreciaciones que se podrían emitir luego de treinta y cuatro años de vigencia de un Código Civil. Es previsible y deseable que, al cumplirse dicho aniversario, distintos juristas y profesores se ocupen, de acuerdo a sus especialidades y preferencias, de analizar los diferentes Libros del Código Civil y evaluar sus bondades, deficiencias, aplicación, necesidades de modificación, etc., sin dejar de mencionar las innumerables modificaciones que ha experimentado. Tampoco resultará extraño que en cualquier balance se aluda o mencione expresamente el trabajo de las cortes, de los Plenos Jurisdiccionales de la justicia ordinaria o de las sentencias del Tribunal Constitucional, que no han sido escasos en materia civil y que, al contrario, han coloreado, de modo transversal, las diversas figuras tradicionalmente nacidas en el Derecho Civil para luego ser acogidas por las constituciones o ser reinterpretadas por la Corte Constitucional a partir de textos y principios constitucionales. No es esa mi intención. Dejo a los mejores dotados y eruditos a cargo de esos detalles y versación. Mi abordaje es otro. Y quizá en ello influya en demasía mi labor de abogado y mi curiosidad académica por la experiencia legal de los Estados Unidos. Mi curiosidad, en todo caso, no implica preferencia por ninguna escuela o movimiento jurídico estadounidense en particular. Pretendo, en las siguientes líneas, evaluar la vigencia del Código Civil como modelo y, en ese orden de ideas, intentaré indagar si, por el contrario, asistimos a la era de las consolidaciones o Restatements con el significado que luego exploraremos. Es claro que el punto de partida es el concepto que se ha acuñado de un código desde la promulgación del Code Civil francés en 1804.
Definiendo el concepto del Incremento Material del Riesgo en la relación de causalidad: ¿podría aplicarse en el Derecho peruano?
Authors: Canepa Casillas Ricardo
Published: November 2020

A través de este ensayo, el autor desarrolla la problemática de los vacíos probatorios que impiden establecer el nexo causal, particularmente cuando, si bien existe certeza de que el daño ha sido causado por una conducta negligente, es imposible determinar quién —o quiénes— dentro de un grupo que incrementó el riesgo de la producción del daño, efectivamente fue quien ocasiona el perjuicio. Como solución, el autor propone que una de las aplicaciones del concepto del “incremento material del riesgo”, la “excepción del individuo indeterminado”, puede implementarse en el ordenamiento jurídico peruano gracias a la flexibilidad que brinda la teoría de la causa adecuada. Sin embargo, para su aplicación debe observarse el desarrollo realizado por la doctrina y jurisprudencia anglosajona, incluyendo las lecciones aprendidas en el camino.
Inflammation lowering property of pistacia atlantica in cotton pellet granuloma
Authors: Naveen B  , RajaSheker K  , Anil Kumar A  , Abhilash G
Published: November 2020

There are few defence mechanisms by which the body identifies and recovers from any physical injuries or external damage-causing stress and stimuli. This is through inflammation wherein the pain and the healing enzymes release into the bloodstream and cause pain and swelling that causes protection from those damages. The most important of the causative factors of the inflammation is the oxidative damage and the physiological stress. There were investigations on the herbs that were used in the treatment of diseases and were claimed to contain very limited or without side effects. Thus, they gained importance these days and were used in the treatment of major diseases like cancer and heart problems. Even though their use was extended from the traditional forms to advanced medicine, their scientific establishment of the proof and validate them for their activities is utmost important. Thus there were gaining interest in the medical and research field to perform the researches on the herbs and medicinal plants to prove their activity. The plant leaves of Pistacia atlantica were extracted with ethanol and water mixture using an ultrasonication. It was tested for the anti-inflammatory potential in various doses like 100, 200, 400 and 600 mg.kg body weight in the swiss albino rats in the cotton pellet induced granuloma method and the extracts showed significant dose-dependent activity compared with the standard indomethacin drug.
Toxicological Studies of the Extract of Epipremnum pinnatum
Authors: Pranitha D  , Ganesh Kumar Y  , Phaneendra Pavan D  , Madhava Reddy Ch  , Akila CR
Published: November 2020

Medicinal plants are of great significance in the evolution of mankind, and the medical systems that are based on the plants and natural resources are gaining importance. Around 50% of the population in the world are using herbal medicine in the present day   . This had been practised and used by many healers and others in the usage of the herbs in emphasizing their potency and lack side effects. The plant, Epipremnum pinnatum had been used as a decorative plant in the houses everywhere, and the plant has some potential properties like insecticidal, and anti-hyperlipidemic activities. In the present investigation, the acute, sub-acute and Chronic toxicity of the extract of the aerial parts of the plant were investigated, and the plant safety was suggested based on the results. In this current work, the acute and chronic toxicities of the extracts of the plant were investigated, and the results showed that there was no abnormal weight gain and signs of toxicity. The rats were healthy too. The blood parameters did not show any changes, too indicating that the extract showed no toxicity on the rats.
Bilateral Simultaneous Ovarian Torsion in Baby
Authors: TAŞCI Aytaç , ARIK Hasan , MERT DOĞAN Güleç
Published: November 2020

Bilateral simultaneous ovarian torsion is rare in pediatric patients. We wanted to share the diagnosis, treatment and results of our patient with bilateral concurrent ovarian torsion with the literature.The three-month-old girl was brought to the emergency room because of unrest for 2 days. Doppler ultrasonography showed no vascularity in bilateral ovaries. The patient was taken into operation immediately. Detorsion was applied to both ovaries. Although the blood circulation of the ovaries did not improve, the ovaries were preserved and no oophorectomy was performed. In the postoperative follow-up, the blood supply of the right ovary began to be observed. The patient is still in follow-up and right ovarian blood supply continues. We presented the 4th case in the literature due to bilateral synchronized ovarian torsion. We wanted to present that the ovarian protective approach in these patients' surgery may be satisfying even in a limited case.
对中国“第三次移民潮”的经济学解读——基于亚当·斯密、马克思和康芒斯三个时代经典著作的基本观点
Authors: 王 洪超 , 谢 元态
Published: November 2020

运用三个不同时代经典著作的基本观点对中国“第三次移民潮”作经济学解读，能获得有价值的启发。首先运用亚当·斯密《国富论》中的人口流动成本理论解读：当前的分工协作已经在全世界范围内安排产业链，需要将经济分析研究语境转变为全球范围。在外国日渐放开的移民政策的吸引下，中国经济转型所需要的高素质人才日渐流失，普通劳动者承受着巨大的生活成本，消费日益萎缩，社会矛盾也会潜滋暗长。然后运用马克思《资本论》中的资本有机构成理论解读：发达国家通过灵活宽松的移民政策来吸引世界各国，尤其是发展中国家青年才俊为其所用。既反映了资本主义国家资本有机构成不断提高的趋势，也令发展中国家陷于不平等的分工格局中难以自拔。随着中国人口红利的消失，老龄社会的提前到来，将使中国的社会保障体制面临更大的压力。最后运用康芒斯《制度经济学》中的利益冲突与效率观解读：移民潮的出现是不同集体之间利益冲突的集中体现，而这种冲突皆源于制度的落后或者缺失。因此，政府当务之急是应该加快富有经济效率的制度建设。
医疗风险与中国农村老年消费行为
Authors: 吴 敏 , 冯 兰
Published: November 2020

基于2015年中国健康与养老追踪调查（CHARLS）数据，检验农村的老年医疗风险与消费行为之间的关系。高医疗支付概率越大，老年人消费水平越低，消费结构越单一。食品消费作为维持基本生存的必要部分，受医疗风险影响小；文娱消费受医疗风险制约大。高医疗支出强化了负向预期与风险意识，老年人通过划拨更多心理账户资金用于医疗储蓄而降低日常消费特别是文娱消费。补充医疗保险通过降低大额医疗支付对消费行为抑制的调节作用以实现经济约束下的多元化消费需求。
电商平台与农场合作模式分析
Authors: 张 娜 , 陈 进
Published: November 2020

中国农业长期面临着产业链环节繁琐、资源效率配置偏低、利益分配不均衡等问题。近年来，随着电商下乡潮流的兴起，中国诸多电子商务平台深入农村生产源头，与农场合作，利用数字技术进行标准化生产，利用平台资源实现产销对接。论文对电商平台与农场的合作模式进行分类，并分析不同条件下不同合作模式的优缺点，针对三个合作模式提出电商平台进行质量监督的几点建议。
关于事业单位政府会计制度实施的思考
Authors: 闫 宇翔 , 徐 一漫
Published: November 2020

在新时期发展背景下，为使事业单位会计核算制度更加完善，并建立一个统一、科学、规范的政府会计核算体系，新政府会计制度于2019年1月1日开始在中国正式实施。新政府会计制度构建了“财务会计和预算会计适度分离并相互衔接”的会计核算模式，事业单位管理水平进一步提高。论文针对新政府会计制度实施过程中遇到的一些问题进行探讨并提出对策建议。
基于顾客视角下的茶饮行业营销策略研究——以“益禾堂”为例
Authors: 黄 震茹 , 刘 彩虹
Published: November 2020

近年来，中国的茶饮业发展十分迅速，“益禾堂”秉承“客户至上，精益求精”，立足于全国高校商圈，突显着在校大学生的消费偏好。论文首先从8个指标基于描述性统计方法分析“益禾堂”的经营现状，然后通过因子分析法研究顾客喜欢它的因素有哪些，结果显示，在8个指标中，可提取4个主成分因子，按照指标权重大小排列分别为：盈利因子（F1），产品因子（F2），运营因子（F3），制作工艺因子（F4），并对各个因子进行线性回归分析，总结出各个因素对顾客喜爱度的贡献，最后对其经营策略提出改进建议。
工业化带动中国贵州刺梨产业快速发展
Authors: 谢 祖逢 , 陈 道琳
Published: November 2020

在中国贵州，刺梨既是十二大优势特色产业之一，又是地理标志产品，其还肩负着以工业化带动农业产业化发展的使命。作为药食同源第一果，刺梨不仅营养丰富，具有保健功效，也是贵州大健康产业发展的重要组成部分。立足新时期，为促进乡村振兴战略实施、积极落实精准扶贫，应重视对特色企业的扶持，使其迈向产业化、现代化发展路径，让更多消费者认识、认可贵州刺梨。在此，笔者立足当前中国贵州刺梨产业发展现状，展开对以工业化带动刺梨产业化发展的策略探析。
基于新冠肺炎疫情下的微信谣言传播机制研究
Authors: 皇 蓝超
Published: November 2020

新冠疫情具有传播范围广、传染性强、潜伏期长、无症状传播、难以预测和难以控制等特点，它的产生及持续发展状况影响大众的切身利益，同时也波及到社会稳定。在互联网发展的时代背景下，微信是使用最频繁的软件之一，在新冠疫情没控制下来的情况下，存在着许多隐患及问题，给新冠疫情的谣言制造与传播提供了条件。互联网具有便利性，但也具备匿名性、虚拟“在场”感，容易蛊惑大众对新冠疫情谣言进行创作、改编、分享、转发。疫情下，微信谣言的危害极大。例如，在2020年中国春节期间造成的双黄连口服液遭到疯抢的事件，谣言瞬间引发整个社会陷入恐慌情绪中，严重危及社会的稳定。因此，论文从四个部分研究疫情下的微信谣言传播机制，分析新冠疫情下微信谣言传播主体的特点以及这期间传播的谣言内容，探析谣言诞生的原因，总结微信谣言造成的不良影响。
论行政事业单位国有资产的全过程管理
Authors: 张 瑛
Published: November 2020

在新时期背景下，随着社会的快速发展，中国国有企业在进行资产管理过程中也需要进行全面的改革，国有资产在过去管理过程中存在着诸多问题，在新时代的背景下，全过程管理已经融入到国有资产管理工作当中。因此，论文针对当前新时期背景下对事业单位国有资产全过程管理工作内涵以及开展全过程管理工作的意义和相关问题进行论述，为中国当前行政事业单位开展国有资产管理水平提升提供参考意见。
智慧城市背景下智慧图书馆馆员胜任力模型构建
Authors: 邹 凯 , 曹 丹 , 蒋 知义
Published: November 2020

随着智慧城市建设的推进，图书馆向智慧图书馆转型成为一种必然趋势,从用户感知视角出发构建智慧图书馆馆员胜任力模型，旨在为提升智慧图书馆馆员胜任力提供借鉴。综合运用定性综合集成、问卷调查法提取24个胜任力要素并构建智慧图书馆馆员胜任力假设模型，借助SPSS软件进行因子分析，根据分析结果验证并修正模型。论文基于用户感知视角建立了以职业信念为核层，以业务能力为中层，以知识结构、技能储备为表层的智慧图书馆馆员胜任力模型。
当代企业危机公关运行的研究
Authors: 段 少清
Published: November 2020

随着市场经济不断发展，各企业在发展中所处市场经营环境变化多端，这就使企业在发展过程中，经常会遇到各种危机事件,同时也为各企业经营管理者敲响了警钟。那么为了保证企业能快速化解危机，并在发展过程中将危险程度降低，企业危机公关就成为各企业稳定运行的必要工作部门。因此，论文针对当代企业危机公关运行进行研究。
政府会计制度改革对行政事业单位资产管理和核算的影响探究
Authors: 李 杰
Published: November 2020

随着社会经济的发展，政府部门的资产、负债、财务支出等业务也不断扩大。以往旧的财务制度已经无法满足政府财务管理的需要，为了能更真实准确地记录行政事业部门的财务状况，更好地控制债务风险，加强资产核算与管理，会计制度的改革是势在必行的。论文分析行政事业单位资产核算与资产管理的现状，指出改革后的新会计制度对于目前这些现状将会产生的影响，并根据这些问题提出相应对策，以期能为政府部门改善财务现状提供有效途径。
浅谈戏剧舞台灯光艺术创新
Authors: 高 继慧
Published: November 2020

灯光是戏剧舞台的重要构成元素，能起到强化舞台效果、烘托环境氛围、提升艺术感染力的作用。论文回顾了戏剧舞台灯光艺术的发展历史，分析灯光艺术对于舞台效果的影响以及戏剧舞台中如何创新应用灯光艺术的几点感悟，以期促进中国灯光艺术在戏剧舞台中的创新应用与发展。
现代文化产业中的动画和数字娱乐设计研究
Authors: 李 怿
Published: November 2020

随着社会经济的不断发展和人们生活水平的提高，人们的审美水平越来越高，现代文化产业获得了迅猛的发展。数字化时代的全面到来给传统文化产业带来了新的生命力，现代文化产业中的动画和与数字娱乐设计技术融合计算机技术获得了持续稳定的发展，能为人们提供更好的艺术体验。论文主要针对现代文化产业中动画与数字娱乐设计的相关策略以及主要方法进行了探究。
从当代艺术看美术馆当代性的发展
Authors: 朱 楠
Published: November 2020

毫无疑问，当代艺术难以界定，而与当代艺术同属于现代化产物的美术馆的当代性也难以界定。美术馆自创立之日起，就具有书写和展示美术史的责任，作品与展览作品的场域对于美术馆而言都是极为重要的。缺乏展品，美术馆成立和发展的根本也就不存在。基于此，论文主从当代艺术作品以及发展形势研究美术馆当代性的发展
让乡村非遗“活”起来——李逸设计师的“设计入乡
Authors: 李 逸 , 曹 子健 , 邢 译文
Published: November 2020

2014年，习近平总书记在联合国教科文组织的演讲中说说道：“应该让收藏在博物馆里的文物，陈列在广阔大地上的遗址，书写在典籍里的文字都活起来，让文物活起来。”论文把“非遗”扩展、聚焦到一般概念上的“泛非遗”视角，意在突出研究本体的突出普遍价值，也更能接近日常，与美好生活紧密联系在一起。论文从中外乡村图景入手，引出乡村非遗“活”的含义，进而提出“中国特色乡村美学经济综合体”作为实操指导，通过实证案例进一步解释其现实意义。
略谈仿生设计在陶瓷设计的应用
Authors: 亓 会锁
Published: November 2020

在陶瓷设计中，仿生设计是一种比较常见的设计方式，科学运用仿生设计技艺，可让陶瓷作品生动活泼，在充满韵味的同时又趣味满满。论文在简要分析仿生设计特点的基础上，就仿生设计在陶瓷设计中的应用展开深入探究，以供参考。
山东理工大学非体育专业排球运动开展现状调查
Authors: 杨 硕
Published: November 2020

排球运动是中国三大球种唯一获得世界冠军和奥运冠军的项目。高校排球运动不仅是高校体育锻炼的主要形式，同时也是高校体育教学的主要内容。如何提高非体育专业学生排球运动的参与情况，是进一步提高和完善高校体育运动的重要内容。
社会工作视角下辅导员工作的创新路向研究
Authors: 石 瑞宝
Published: November 2020

新时期，高校辅导员开展大学生思想政治教育工作面临新问题与新挑战，要想有效地解决这些问题，辅导员必须不断创新现有的工作方式、方法。而社会工作方法，因其与思想政治教育的契合性及其在解决学生问题中具有的独特优势，为高校辅导员工作带来新的思考与实践。本研究通过探索总结社会工作方法在大学生思想政治教育中的具体应用，促使辅导员借鉴专业方法，创新工作模式，更好地满足学生成长发展需求。
高中英语阅读教学的方法探究
Authors: 费 天霞
Published: November 2020

英语在日常生活中发挥着重要的作用，所以学校非常重视英语学习，尤其是英语阅读教学。但是当前英语阅读教学的方法存在一些问题，这就导致学生长期以来难以提高自身的阅读能力。因此，在未来的英语教学过程中，教师需要反思高中英语阅读教学中面临的阻碍，并对高中英语阅读教学中面临的情况进行深入分析，参考一些高中英语阅读教学改进策略的文献资料，并且提出一些具体的改进建议。
在职专英语教学中运用教材知识点给学生灌输生命教育
Authors: 梁 植军
Published: November 2020

生命在我们的语境中似乎一直是讳莫如深的话题，我们都想长命百岁，可是发生在周围太多的事例都在告诉我们：我们不知道如何爱惜生命。在现行的职专英语教材中，通过话题教学，笔者挖掘出许多与热爱生命有关的内容，与学生实际生活相联系，取得不错的效果；一学期的英语教学，学生不但提高了英语学习的积极性，而且养成了良好的生活习惯和行为习惯，笔者认为最重要的是，他们逐步有了成长性思维，用每天的行动步量出美好的未来。
基于混合式教学模式的高职思政课信息化教学设计——以“绿水青山就是金山银山”为例
Authors: 陈 豪丽
Published: November 2020

讲好思政课必须与时俱进，改革创新。在信息化背景下，如果教学因循守旧，缺乏亲和力和感染力，则很难取得实效。只有不断改进探索教学方法，实时增强思政课的时代感和吸引力，才能增强学生的获得感。论文以“绿水青山就是金山银山”为例，阐述了“线上线下”混合教学模式在高职思政课堂上的应用过程。通过别开生面的信息化教学设计，增强了学生学习的积极性，取得了良好的教学效果。
模拟法庭在专科医学生医德教育中的作用研究
Authors: 赵 俊华
Published: November 2020

通过数据统计可以看出，医疗纠纷案主要是因为医务人员医德及法律意识薄弱造成的。针对医学生医德教育，采用调查问卷，确定医德认知现状，再采用网络模拟法庭这一形式，结果显示可同时达到医学知识、医德、法律知识综合教育效果，并提出在校、在临床综合医德教育的方法。
双一流建设背景下中国西部高校管理干部队伍建设思考
Authors: 丁 智慧
Published: November 2020

一流的管理是建设一流高校的保障。目前西部地区高校管理干部队伍建设在认识，培训、考核、晋升机制等方面存在问题， 为充分发挥管理干部队伍在“双一流”建设中的重要作用，应采取相措施， 使高校管理干部队伍的整体素质得以迅速提高。
如何发挥教师的主导作用，让传统国画课堂变得更有活力——浅析小学国画课堂多元化教学方法
Authors: 祝 紫君
Published: November 2020

中国画是中国传统文化的精髓，儿童学习中国画，从小接受中国传统艺术的熏陶，能培养民族自豪感。然而，传统国画学习的过程是枯燥乏味的，学生在反复训练技法、临摹的过程中，不仅对国画这门艺术失去了兴趣和热情，同时儿童的想象力和创造力被扼杀。那么，导致这一现象的原因是什么？我们又如何让儿童在学习、创新传统笔墨技法的同时又能保持他们对国画的兴趣呢？教师的主导作用就显得尤为重要。
Covid-19 salgını sonrası yetişkin bireylerin beslenme alışkanlıklarındaki değişikliklerin değerlendirilmesi
Authors: MACİT Melahat Sedanur
Published: November 2020

Amaç: İlk olarak Çin’in Wuhan kentinde ortaya çıkan yeni koronavirüs (Covid-19) tüm Dünya’da yaygın hale gelmiş ve Dünya Sağlık Örgütü tarafından pandemi olarak ilan edilmiştir. Covid-19’dan korunmada tek çözümün sosyal mesafe ve kişisel hijyen olduğu bilinmektedir. Bunun yanı sıra immün sistemi güçlü bireylerin hastalığa yakalanma ve iyileşme sürecinde avantajlı oldukları sıklıkla vurgulanmaktadır. Bireylerin immün sistemi güçlendirmek için beslenme düzenlerini değiştirebileceği ve karantina uygulamalarıyla birlikte toplumun evde kalış sürelerinde artış olacağı öngörülmekte ve bunların beslenme durumuna etki edebileceği düşünülmektedir. Bu doğrultuda bu çalışmada bireylerin Covid-19 sonrası bazı beslenme alışkanlıkları ve etkileyen faktörlerin değerlendirilmesi amaçlanmıştır. Yöntem: Çalışmaya 18-65 yaş arası toplam 341 birey dahil edilmiş, Google Docs formları aracılığıyla beslenme, uyku, fiziksel aktivite, duygu-durumlarını araştıran bir anket ile değerlendirmeler yapılmıştır. Bulgular: Bireylerin %17’si erkek (n=58), %83’ü (n=283) kadındır. Tüm katılımcıların % 70.4’ü (283) iş veya uzaktan eğitim dolayısıyla evden çalışma sistemine geçmiş ve toplam ortalama 17.30±13.9 günü bulan bu sürede 1.0±1.5 kg vücut ağırlığı artışı olduğunu beyan etmişlerdir. Bireylerin % 80.9’u (n=276) fiziksel aktivitede azalma, %48.7’si uyku süresinde artış olduğunu ifade etmiştir. Bireylerin % 71.6’sı uyku süresindeki bu artışın besin alımında artışa neden olduğunu belirtmiştir. Bireylerin yaklaşık üçte biri (%) başta D vitamini (% 56.9), C vitamini (%50.4) ve Çinko (%27.6) olmak üzere besin takviyesi kullanmaya başladığını bildirmiştir. Covid-19 sonrası bireylerin % 17.5’i beyaz ekmek, %16.7’si meyve, %15.5’i çikolata tüketimlerinde artış olduğunu beyan etmiştir. Sonuç: Çalışma sonuçları bireylerin Covid-19 sonrası beslenme, uyku ve fiziksel aktivite düzenlerinde değişiklikler olduğunu göstermektedir. Bireylerin takviye kullanımı Covid-19 sonrası artış göstermiştir. Bu sonuçlar doğrultusunda bireylerin yeterli ve dengeli beslenme, fiziksel aktivite ve takviye kullanımı konusundan bilgilendirilmesi gerektiği düşünülmektedir.
THE DIGITAL ECONOMY AS AN IMPORTANT CONDITION FOR THE SUSTAINABLE DEVELOPMENT OF THE NATIONAL ECONOMY
Authors:   Gulistan State University of the Republic of Uzbekistan, Abduvohidov Akmal , Muxametov Abubak , Berdiev Gayrat , Toshboev Bekzod
Published: November 2020

This article is based on the study of the experience of developed countries of the world and justifies the role and importance of digital technologies and the digital economy in the sustainable development of the country
GENERAL ECONOMIC AND SOCIAL PROBLEMS IN INNOVATIVE AND DIGITAL ECONOMY
Authors:   Samarkand economy and service institute of the Republic of Uzbekistan, Usmanova Nigina
Published: November 2020

The article describes the development of the global digital economy, the work carried out in our country, the problems of economic and social innovations and efforts to solve them
Integrated application of biological and chemical preparations against alternariosis of pota-toes in irrigated conditions of the Volgo-Ahtubinskaya pool
Authors: Korneva Olga Georgievna , Bairambekov Shamil Bairambekovich , Polyakova Ekaterina Viktorovna , Batyrov Vladimir Aleksandrovich
Published: November 2020

In the conditions of the Astrakhan region Alternaria blight is one of the most widespread and harmful diseases. The application of only chemical preparations often leads to the emergence of resistant forms of pathogens. One of the methods to solve this problem is the combined usage of chemical and biological preparations. The article shows the possible loss of yield of potato tubers in the absence of measures to control this disease. Is it described biological preparations that are produced on the basis of one of the most diverse and naturally diffused bacteria of the Bacillus genus, which are able to inhibit the development of a wide range of plant pathogenic fungi. The characteristics of the variety, conditions and methods of research are given. The article presents the results of trials of the combined application of chemical and biological preparations against potato Alternaria blight under irrigated conditions of the Volga delta with cultivation of potato under on drip irrigation. It was noted that pre-planting treatment of potato tubers with biological and chemical preparations contributed to the growth of field germination rate by 4,3-7,6%. The combination of preplant treatment with spraying of vegetative plants positively influenced the biometric parameters of potato bushes, increasing the number and weight of leaves, the average height and number of productive stems, as well as the mass of tops and tubers. In comparison with the control variant without treatment the leaf surface area increased by 15-29%. The results of the estimation of effectiveness of the combined use of biological and chemical preparations against potato Alternaria blight are presented. It was established that the degree of the Alternaria blight development during the vegetation period was below the control by 30-76%. It was also mentioned an increase in the productivity of cultivated plants without a significant decrease in the quality of potato tubers.
Use of cumin and lavender essential oils to control phoma exigua var. foveata on potato during storage
Authors: Mohammed Sabah Rabie , Melnikov Aleksey Vasilievich
Published: November 2020

The antifungal activity of essential oils against Phoma exigua var foveata, was investigated by analyzing its inhibitory effect on the gangrene of potato tubers. The results showed that mycelium growth and spore germination of Phoma was suppressed by treatment with essential oils, and the inhibitory effect strongly correlated with the concentration of essential oils used in this study. The effectiveness of post-harvest treatment with essential oils was studied for induced resistance to Phoma rot in tubers of two potato varieties (Kolobok and Sante). The results showed the fungicidal effect of cumin and lavender essential oils against phomosis at concentrations of 0.1, 0.2, and 0.4, significant inhibition of mycelium growth (18.1-100%), and viability of conidia (12.8-100%) compared to the control. Moreover, both oils at a concentration of 0.4% caused 100% inhibition of mycelium growth and spore germination. Treatment with oils at a concentration of 0.01-0.04 l/t significantly reduced the degree of damage to tubers infected with phomosis. However, cumin essential oil at a concentration of 0.04 l/t had the greatest effect 97.1% compared to lavender oil 95.4%.
Influence of Biocomplex-BTU on changing the nutritional value and energy value of silage produced from cereal-legume components based on oats
Authors: Puzik Alexander Aleksandrovich , Nikitin Alexander Nikolaevich
Published: November 2020

The article presents experimental material on changing the quality of a bean-silage with the introduction of the Biocomplex-BTU. The influence exerted by silos harvested on its basis on the productivity of dairy herds of large horned animals was revealed. A change in the nutrient content when using this biocomplex has been established.
Effect of silicon dimethylglycerolate on ripeing of sheep oocytes in vitro
Authors: Stanislavovich Tatyana Ivanovna
Published: November 2020

In the presented study, a positive effect of a silicon-containing compound, silicon dimethylglycerolate (SDMG), on cells of cumulus expansion and nuclear maturation of sheep oocytes was established. This chemical compound is characterized by wound healing, regenerating and transmucosal activity. The introduction of 0.2% SDMG into the composition of the culture medium as an additional component increased the level of oocytes with expanded cumulus (33% versus 21%, P <0.05). The yield of oocytes that reached the final stage of meiotic maturation was 88% under the conditions of using SDMG versus 71% (P <0.05) in the control group. The results obtained suggest the possibility of using SDMG in the technology of extracorporeal maturation of donor sheep oocytes.
Doğu Anadolu Bölgesinde Kaz Eti Üretiminde Organik Üretim Olanaklarının Değerlendirilmesi
Authors: HANOĞLU ORAL Hülya , AK İbrahim
Published: November 2020

Bu çalışmada Doğu Anadolu bölgesinde organik hayvancılık ilkelerine benzer bir yetiştiricilik ile yapılan ekstansif kaz yetiştiriciliğinin organik üretim koşullarına uygun olup olmadığı ve organik kaz eti üretim olanakları değerlendirilmiştir. Kazlar diğer kanatlılardan farklı verim özelliklerine sahip, hastalıklara karşı daha dayanıklı,  barınak gereksinimleri daha az olan ve mera otlarını değerlendirebilen sindirim sistemine sahip bir kanatlı türüdür. Türkiye’de kaz yetiştiriciliğinin yerli ırklarla ve çoğunlukla küçük aile işletmelerinde yapılması, kazların diğer kanatlı hayvanlara göre hastalıklara daha dayanıklı olmaları ve Doğu Anadolu bölgesinde iklim koşulları, su kaynakları ve geniş mera alanlarının bulunması, ekstansif olarak yürütülen kaz yetiştiriciliğinin organik üretim koşullarına uygun olabileceğini göstermektedir. Öncelikli olarak et üretimine yönelik olarak yapılan kaz yetiştiriciliği, meraya bağlı olarak ekstansif sistemle gerçekleştirilmekte, et üretimi kimyasal kullanılmamış doğal meralara dayalı olarak yapılmaktadır. Bölgede barınak koşullarının düzenlenmesi ve meraya ek yemleme için organik yem üretimi ve kullanımı ile organik kaz yetiştiriciliği mümkün görülmektedir. Bölgeye yönelik eko turizmin yaygınlaşması ve kaz etine talebin artması, organik kaz eti ihraç potansiyelinin yüksek olması nedeniyle organik kaz yetiştiriciliği bölge hayvancılığının geleceği açısından önem taşımaktadır.
Tarımda Kullanılan Bazı Mikrobiyal Gübrelerin Eisenia Foetida Deri Dokusu Üzerinde Etkisinin Morfolojik Açıdan Değerlendirilmesi
Authors: YAYLA Şeyma Rukiye , ŞENOL Nurgül
Published: November 2020

Bu çalışmada son yıllarda kimyasal gübrelerin yol açtığı çevresel zararlardan dolayı alternatif olarak üretilen mikrobiyal gübrelerin Eisenia foetida türü toprak solucanlarının deri dokusu üzerine etkisinin histolojik açıdan değerlendirilmesi yapılmıştır. Tarımda şu anda kullanılmakta olan 3 farklı mikrobiyal gübre formülasyonu ile Eisenia foetida türü solucanlara 30 gün boyunca sıvı mikrobiyal gübre (BM Coton Plus, BM Megaflu, BM Rootpan) uygulaması yapıldı. Denemenin ardından Eisenia foetida’ların vücut kısımlarından belli parçalar alındı ve histolojik doku takibi uygulandı. Kontrol grubuna ait preparatların histolojik incelemesinde derinin epidermis ve dermis olmak üzere tabakalanma gösterdiği saptandı. BM Coton Plus, BM Megaflu, BM Rootpan gruplarımızda da kontrol grubumuza benzer histolojik gözlemler yapıldı. Sonuç olarak mikrobiyal yöntemler seçilmesinin tarımın sürdürülebilirliği ve toprak canlılarının yaşam döngülerinin devamını sağlamak açısından herhangi bir olumsuzluk oluşturmadığı histolojik açıdan tespit edildi.
First-Principles Study on Magnetic Nature and Electronic Behavior of Silver-Based Sulfide: Ag3MnS4
Authors: ERKİŞİ Aytaç , SURUCU Gokhan
Published: November 2020

This investigation is about the electronic and magnetic character of the ternary silver-based sulfide (Ag3MnS4) crystallized in sulvanite type crystal structure with space group P4 ̅3m and space number 215. The mentioned characteristics has been examined by Generalized Gradient Approximation (GGA) with spin effect under Density Functional Theory (DFT). Four different magnetic phases have been considered to investigate the proper magnetic order for this system. As a result of calculations, it has been understood that, for Ag3MnS4 compound, the energetically most favored magnetic order is A-type antiferromagnetic. After the well-optimized structural parameters and relaxed atomic positions in its suitable magnetic order have been obtained, the electronic characteristic of this antiferromagnet system indicating semiconducting behavior due to the observed a small direct band gap (Eg = 0.325 eV) in both spin states, has been investigated. Also, this compound has thermodynamic stability and structural synthesizability due to its calculated negative formation energy values for all different type magnetic phases.
Magnetic moment of Zc(3900) as molecular state
Authors: ÖZDEM Ulaş
Published: November 2020

Employing light-cone QCD sum rule, we have acquired the magnetic moment of the Zc(3900) resonance by considering it as the molecular form of D(D^* ) ̅ and D^* D ̅ resonance with quantum numbers JPC = 1+−. The magnetic moment contains crucial knowledge about the internal organization of particles and their geometric configuration. Measurement of the magnetic moment of the Zc(3900) resonance in future experiments can be quite useful comprehension the inner organization of exotic resonances. A comparison of our numerical values on the magnetic moment with those estimated by the other theoretical models existing in literature is carried out.
Experimental Studies and DFT Calculations of a Novel Molecule Having Thieno[3,2-b]thiophene Fragment
Authors: YÖRÜR GÖRECİ Çiğdem
Published: November 2020

A novel molecule of thieno[3,2-b]thiophene-2,5-diylbis[N-(4-chlorophenyl)methanimine] (TTBM) was synthesized using thieno[3,2-b]thiophene fragment, and characterized using UV-Vis, FTIR, 1H NMR and LC-MS spectroscopy. Quantum chemical properties of TTBM were investigated via DFT method using B3LYP hybrid functional with 6-311G(d,p) basis set. Optimized molecular structure, UV, FTIR, HOMO-LUMO energies and Molecular Electrostatic Potential (MEP) characteristics of TTBM were studied by means of DFT. The assignments of the vibrations in the molecular structure were performed by using the VEDA4 program with potential energy distribution (PED). The experimental spectra of TTBM (UV-Vis and FTIR) were compared in detail with the theoretical results and were seen to be in a good agreement with each other.
Halojen Atomları ve Siyano Grubunun Hekzasen Molekülünün Optik, Elektronik ve Yük Transfer Özellikleri Üzerine Etkisinin İncelenmesi: Moleküler Dizayn Yöntemi, Yapı-Özellik İlişkisi
Authors: YAKALI Gül
Published: November 2020

Bu çalışmada, π-konjugasyon yapısına sahip hekzasen molekülü, farklı halojen atomlar (Flor, Klor, Brom) ve molekülde farklı konumlandırılmış siyano grupları ile dizayn edilmiş, elektronik, optik ve yük transfer özellikleri zamana bağlı ve zamandan bağımsız Yoğunluk Fonksiyon Teorisi (YFT) ile incelenmiştir. Dizayn edilen beş hekzasen türevinin yapı ve özellik arasındaki ilişkiyi kurabilmek için, moleküler geometri, reorganizasyon enerji, HOMO-LUMO orbital enerjileri, iyonizasyon potansiyeli (IP), elektron afinitesi (EA), geometriden dolayı nötr ve yüklü durumlara bağlı olarak bağ uzunluğu değişimi (BUD) üzerine substitüe etkisi incelenmiş ve etkiyi daha iyi anlayabilmek için sonuçlar hekzasen ve antrasen moleküllerin sonuçlarıyla karşılaştırılmıştır. Moleküllerin, elektron enjeksiyon bariyerinin hekzasen molekülünden daha düşük olduğu ve iyi bir boşluk taşıyıcısı olarak bilinen antrasenle kıyaslanabilir derecede etkili boşluk yük transfer oranına sahip olduğu belirtilmiştir. Dizayn edilen hekzasen türevlerinin, optoelektronik alanda potansiyel uygulamalar için ilgi çekebileceğini ve malzeme biliminde umut vaad edeceğini umuyorum.
Inflammatory Biomarkers Predictive of Metabolic Syndrome in a Nigerian Population: A Case-Control Study
Authors: Adejumo EN , Adejumo OA , Ogundahunsi OA
Published: November 2020

Background: Inflammation is linked to the aetiopathogenesis of Metabolic syndrome (MetS).

Objective: To assess the ability of high sensitivity C-Reactive Protein (hs-CRP), Tumour Necrosis Factor-alpha (TNFα) and Interleukin-6 (IL-6) to predict MetS.

Methods: A case-control study involving 123 subjects with MetS (cases) and age-matched 123 subjects. without MetS (controls) was conducted. The levels of TNFα, IL-6, and hs-CRP between independent groups were compared. The Receiver Operative Characteristic Curve was used to assess the ability of inflammatory markers to discriminately identify MetS.

Results: The mean age of the case and control groups was 49.9±0.9 years and 48.1±1.1 years (p = 0.274) respectively. The median levels of TNFα, IL-6 and hS-CRP were significantly higher among the cases than the control group in both genders (p <0.001). There was a significant increase in the serum values of the markers with increasing components of MetS (p <0.001). The Area Under the Curve of TNFα, IL-6 and hs-CRP was > 0.9 in both males and females.

Conclusion: TNFα, IL-6, and hs-CRP identified MetS. There is a need for further studies to determine the inflammatory marker most predictive of MetS.
IMPROVEMENT OF THE SYSTEM OF MANAGEMENT OF PROFESSIONAL DEVELOPMENT OF PERSONNEL: THE CASE OF UKRAINE
Authors: Makarenko Serhii , Oliinyk Nataliia , Oleksenko Yana
Published: November 2020

Theoretical and methodical aspects of rating performance appraisal of scientific and pedagogical workers of educational institutions are object of research. The purpose of the article is to study the factors of influence and provide recommendations for improving the system of management of professional development of personnel of educational institutions. The results are obtained through the use of methods: expert method is used to identify the impact of qualitative and quantitative indicators on the efficiency of use of labor resources; economic and mathematical method is performed to determine the integral indicator of the assessment of the efficiency of the use of labor resources; abstract-logical method is executed for theoretical gen-eralization and formulation of conclusions. It has been revealed that the lack of a sound methodological approach to employee rating and appropriate means of motivation for professional development can lead to the loss of existing intellectual potential and competitive positions of educational institutions in the market of educational services in general. It has been found that in order to introduce an effective model of personnel management in educational institutions, it is very important to provide the main criteria for evaluating its effectiveness at the stage of formation. It was found that special attention should be paid to development of substantiated scientific and methodological approaches to the assessment of pro-fessional qualifications level of employees in the testing group and in the dynamics, determining the limit load and development model of a motivation model for professional development. When assessing the level of professional qualification of teaching staff, it is proposed to take into account not only their own property to scientific and pedagogical industry, but also the results of their pupils’ work. In determining the integral indicator of the assessment of the efficiency of the use of labor resources, the method of taxonomic analysis was used with additional consideration of the specific weight of influence of each factor on an integral indicator. It is substantiated that the definition of the boundary load will not only establish an effective bonus system, but also increase the level of job satisfaction among subordinates. The mechanism of determining the coefficient of competence of experts involved in the evaluation of staff, taking into account their work experience, the scale of management activity, and the level of education, deserves further study.