bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of youth friendly services at public health facilities in Debre Birhan Town: A mixed study
Authors: Goshu Zeleke , Amera Michael , Nigussie Tirusew , Tesfahun Esubalew , Zekarias Fitsum
Published: September 2024

Introduction: Adolescents and youths require access to high-quality, youth-friendly services to address challenges related to sexual health, relationships, and the potential for early parenthood. In response, both the World Health Organization and the Ethiopian government have developed and implemented various strategies. However, despite these efforts, the quality of youth-friendly services provided by health facilities in Ethiopia remains inadequate.
Objective: the aim of this study was to assess the quality of youth friendly services provided in public health facilities in Debre Berhan town, 2023
Methods: A facility-based cross-sectional study, incorporating both quantitative and qualitative methods, was conducted from May 1–30, 2023. The quality of youth-friendly services was assessed using the Donabedian framework, which evaluates structure, process, and output components. Data were collected through a systematic sampling technique, utilizing an interview-administered questionnaire and an observation checklist. A significant association was identified using an adjusted odds ratio, with a 95% confidence interval and a P-value of less than 0.05.
Results: In this study a total of 422 youth friendly service clients’ age between 10-24 years were participated. The quality of youth-friendly services was 70.7%, 41.3, and 50.5% for structural, process, and output quality dimensions, respectively. Age (15-19) (AOR=0.31,95% CI:0.17, 0.56), clients who waited less than 30 minute (AOR=4.58,95% CI:1.67,12.55), clients who waited 30 minute to one hour(AOR=3.65,95% CI: 1.88, 7.06), not comfortable with sex of service providers (AOR=0.37,95% CI: 0.18,0.76), and payment status free of charge (AOR=2.38, 95%CI:1.36, 4.18) had statistically significant association with client satisfaction.
Conclusion: The study shows that, the overall quality of youth friendly service at public health facilities of Debre Birhan town was 54.2%, which was below the standard of care.
TREATMENT OF TRAUMATIC AMELOGENESIS IMPERFECTA THROUGH MICRO-ABRASION TECHNIQUE: A CASE REPORT
Authors:   Department of Conservative Dentistry and Endodontics, Faculty of Dental Medicine, Hassan II University, Casablanca, Morocco., Aly Sy , Kharroubi Soukaina El ,   Department of Conservative Dentistry and Endodontics, Faculty of Dental Medicine, Hassan II University, Casablanca, Morocco., Jalila Dakkaki ,   Department of Conservative Dentistry and Endodontics, Faculty of Dental Medicine, Hassan II University, Casablanca, Morocco., Hafsa El Mrini ,   Department of Conservative Dentistry and Endodontics, Faculty of Dental Medicine, Hassan II University, Casablanca, Morocco.
Published: September 2024

In recent decades, several ultra-conservative techniques have been employed for the treatment of amelogenesis imperfecta, primarily based on non-invasive procedures. In this article, we will shed light on the technique of microabrasion, its indications, advantages, and limitations. Subsequently, we will illustrate the steps of the technique with a clinical case. Finally, we will discuss the short-term and long-term outcomes. The microabrasion technique has proven effective as a non-invasive alternative among the array of proposed treatments for white and brown enamel lesions.
VEGETATION COVER DYNAMICS OF THE ECOLOGICAL CORRIDORS OF MAYO-KEBBI WEST IN CHAD FROM 2009 TO 2019
Authors:   Cames Associate Professor, Research Professor at the National Center for Research and Development., Man-Na Djangrang
Published: September 2024

This study highlights the application of remote sensing and Geographic Information Systems (GIS) in monitoring vegetation formations in the Mayo-Kebbi West province. The general objective of this study is to contribute to better management and conservation of vegetation formations in the Lere-Binder wildlife reserves, Sena-Oura National Park, and the Yamba Berte forest formation. The spatio-temporal evolution of vegetation was analyzed using Sentinel imagery from 2009 and 2019. The results and matrix analyses showed that 42.86% of the land cover units (grassland, shrubland to woodland, and flood zone) experienced a regression of 7.6 ha per year, while 57.14% (water bodies, fields, gallery forest, and open forest) showed progression. It is noteworthy that the main factors driving vegetation degradation are agriculture, livestock farming, logging, charcoal production, and gold mining.
CLINICAL IMPACT OF DIODE LASER ON TRUENESS, PRECISION, AND QUALITY OF LIFE OF COMPLETE DENTURE WEARERS (CLINICAL STUDY)
Authors:   Associate Professor, Department of Prosthetic Dentistry, Faculty of Dentistry, Fayoum University, Egypt., A. Emarah Amr , Ahmad Mohamad Omayma ,   Lecturer, Department of Prosthetic Dentistry, Faculty of Dentistry, Fayoum University, Egypt., M. Dehis Wessam ,   Associate Professor at Fixed and Removable Prosthodontics Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt.
Published: September 2024

Background: Candida Albicans (C. albicans) is a major fungal infection affecting the majority of complete denture wearers and causes denture stomatitis (DS) which has many local treatment modalities, such as Chlorohexidine mouthwash and the Diode Laser. Their clinical impact on denture Accuracy, Retention, and the Patients ability to utilize dentures normally has not yet been discussed. Hence, a complete dentures Accuracy titled Trueness and Precision is a vital hidden key for achieving its success post-disinfection. Objectives: This studys objective was to evaluate and compare Diode Laser and Chlorhexidine mouthwashs impact on Trueness, Precision, Retention, and the Patients oral health-related quality of life (OHRQoL) in complete denture wearers. Materials and Methods:An overall of 16 complete edentulous patients were elected, dentures constructed from Heat-cure acrylic resin, and grouped equally owing to the antifungal disinfectant employed into Group I (Diode Laser) and Group II (Chlorhexidine). Assessments were carried out pre- and post-disinfectant application in both groups. The Pre-Disinfectant assessments of Trueness and Precision took place before delivery whereas, those of Retention andOHRQoLwere carried out immediately post-delivery. All the Post-Disinfectant assessments were carried out 60 days following delivery. Results: There was an insignificant difference between Diode Laser and Chlorhexidine mouthwash regarding Trueness, Precision, Retention, and OHRQoLin maxillary complete dentures. Conclusion:It has been concluded that the Diode Laser beam and the 2% Chlorhexidine mouthwash are safe antifungal Heat-cure CD disinfectants regarding Trueness, Precision, Retention, and the OHRQoL.
POWER SECTOR MANAGEMENT FAILURE AND LOAD SHEDDING IN ZAMBIA
Authors: Chimbaka Besa
Published: September 2024

This paper examines the management failures within Zambias power sector and their direct linkage to the persistent issue of load shedding. It highlights the critical role of ZESCO, the state-owned utility, in navigating financial constraints while attempting to meet the electricity demands of both domestic consumers and export contracts. The study identifies key factors contributing to load shedding, including inadequate infrastructure, demand forecasting failures, and political influences that prioritize short-term gains over sustainable energy solutions. Furthermore, the paper discusses the potential of diversifying energy sources, such as solar and wind, to mitigate reliance on hydroelectric power and enhance resilience against climate variability. Recommendations for comprehensive strategies to address the energy crisis and improve load management are provided, emphasizing the need for long-term planning and investment in renewable energy initiatives.
A RETROSPECTIVE STUDY OF RISK FACTORS, CLINICAL PRESENTATION, OUTCOME OF ECTOPIC PREGNANCY
Authors:   Post Graduate, Department of Obstetrics and Gynaecology, Basaveshwara Teaching and General Hospital, Attached Mahadevappa Rampure Medical College, Kalaburagi., Mallinath Hiregouda Jyothi , Itagi Laxmi ,   M.S.Obstetrics and Gynaecology, Professor, Department of Obstetrics and Gynaecology, Basaveshwara Teaching and General Hospital, Attached Mahadevappa Rampure Medical College, Kalaburagi., Devarmani Meenakshi ,   M.S.Obstetrics and Gynaecology, Professor, Department of Obstetrics and Gynaecology, Basaveshwara Teaching and General Hospital, Attached Mahadevappa Rampure Medical College, Kalaburagi.
Published: September 2024

Introduction: Ectopic pregnancy refers to a pregnancy where the fertilized egg implants outside the uterus, in a location unsuitable for its growth and development. The significance of ectopic pregnancy has increased due to its rising incidence and its impact on female fertility. It continues to be a major challenge in modern gynecology and is a significant cause of morbidity and mortality among women. Methodology: This study is a retrospective analysis of 40 cases of ectopic pregnancy conducted in the Department of Obstetrics and Gynecology at Basaveshwara Teaching and General Hospital, Kalaburagi, over a two-year period. The study examined detailed patient histories to identify risk factors, clinical presentations, and outcomes. Results: Out of 3600 confirmed pregnancies during the study period, 40 were ectopic, resulting in an incidence rate of 70% and 30% in the age group of 21-30 years and 31-40 years respectively. Identifiable risk factors were present in 58% of cases, with 26% having a history of pelvic inflammatory disease, 13.3% with infertility, 15% with a history of abortion, 23% with tubectomy, 3% were smokers, and 46% had a previous cesarean section. Among the patients, 16% were primigravida, 83% were multigravida, and 100% presented with amenorrhea. Additionally, 80% reported abdominal pain, 70% experienced vaginal bleeding, 16% had fainting or syncopal episodes, 56% showed signs of pallor, and 5% were in shock. Conservative treatment was administered to 5% of patients, while 95% underwent exploratory laparotomy, and 90% required blood transfusions. Conculsion: Early diagnosis of ectopic pregnancy is crucial and necessitates a high degree of clinical suspicion, particularly in cases presenting with amenorrhea, abdominal pain, and vaginal bleeding. The importance of timely diagnosis lies in the potential to offer conservative management, which can positively impact the patients future fertility.
THE POLITICAL ENVIRONMENT AND ITS ROLE IN ATTRACTING FOREIGN INVESTMENT TO IRAQ
Authors:   Assistant Professor, Department of Economics College of Economics and Administration, Al-Iraqia University Baghdad - Iraq., Najm Almashhadani Abdulrahman
Published: September 2024

This study aims to assess the impact of political stability on foreign direct investment in Iraq. After 2003, the Iraqi government sought to attract foreign investment to address the growing disparity between available resources and increasing financial needs. The goal was to bridge the national resource gap, reduce the balance of payments deficit, and finance public investment to aid in the countrys reconstruction and industrial advancement. To achieve this, Investment Law No. 13 of 2003 was enacted, accompanied by various policies, procedures, guarantees, incentives, and benefits to encourage foreign direct investment in Iraq and support economic development. However, despite these efforts, the inflow of investments did not meet expectations due to persistent political and security instability. This instability led to weak global rankings and deterred both foreign and local investments from Iraq between 2013 and 2022.
IT Affordances, Flow, and Perceived Scarcity: A Study on Impulsive Buying Behavior and Post-Purchase Dissonance in Live Shopping
Authors: Simanjuntak Evi Rinawati , Pratama Rendy Setya
Published: September 2024

Live shopping has evolved significantly as extensive publications have explored this phenomenon from the perspective of streamers and consumers. However, there is limited analysis from the human-computer interaction perspective, particularly concerning IT affordances. Therefore, the research aimed to enhance the understanding of human-computer interaction in live streaming sessions, exploring flow experiences and the influence on impulsive buying behavior, which led to postpurchase dissonance. The moderating role of perceived scarcity was also examined. The research adopted convenience sampling and obtained 250 online survey responses. The data were analyzed using Partial Least Squares - Structural Equation Modeling (PLS-SEM) to test the hypotheses. The results show that three IT affordance components, visibility, metavoicing, and interactivity, foster flow experiences, but guidance shopping does not. Furthermore, flow experiences are found to stimulate impulsive buying behavior, which subsequently leads to post-purchase dissonance. The results further show a negative impact of perceived scarcity on buying behavior, while the effect of scarcity is  anticipated to enhance buying motivation. These results contribute to understanding the significant drivers of flow experiences in live shopping and the implications of perceived scarcity. Enhancing interactive communication between streamers and viewers is essential for businesses while promoting attractive visibility and comprehensive product information during live shopping sessions. Additionally, scarcity effects should be approached with caution only when  necessary to accelerate the call to action.
Social participation and its relationships with sensorimotor and functional aspects in post-stroke patients
Authors: De Araújo Denise Soares , Gomes Camila Lobo de Aguiar , Gondim Afonson Luis Medeiros , Dantas Emanuel Sávio de Macedo , Pacheco Thaiana Barbosa Ferreira , Cacho Roberta de Oliveira , Cacho Enio Walker Azevedo
Published: September 2024

Objective: To describe social participation and assess its correlation with sensorimotor impairment and functional independence in patients after a stroke in a region of Northeast Brazil. Methods: A cross-sectional study was conducted with 34 stroke patients, aged 18 years or older, selected for convenience from the institution's health records. Participants were assessed using the following clinical instruments: Assessment of Life Habits 3.1 (LIFE-H 3.1), Functional Independence Measure (FIM), Fugl-Meyer Assessment (FMA) - motor subsection (upper limb-UL and lower limb-LL), and Nottingham Sensory Assessment (NSA). Results: Post-stroke patients exhibited reduced social participation (LIFE-H 3.1), with moderate positive correlations observed between the personal, mobility, and responsibility domains and the total scores of FIM, FIM motor, FMA-motor, and FMA-UL. There was a moderate positive correlation between the total scores of LIFE-H 3.1, FIM, FMA-motor, and FMA-UL. Conclusion: The present study demonstrated a critical loss of social participation in post-stroke subjects, likely attributed to various sensorimotor and functional aspects, in a semi-arid region of Northeast Brazil.
Avaliação da sobrecarga de cuidadores familiares de pacientes em tratamento quimioterápico
Authors: De Oliveira Amanda Silva , Sardinha Ana Hélia de Lima , Corrêa Rita da Graça Carvalhal Frazão , Coutinho Nair Portela Silva , De Vasconcelos Eliane Maria Ribeiro , Rolim Nivya Carla de Oliveira Pereir , Oliveira Aluisio da Silva , Câmara Joseneide Teixeira
Published: September 2024

Objetivo: Avaliar a sobrecarga dos cuidadores familiares de pacientes oncológicos em tratamento quimioterápico e associar a sobrecarga do cuidador com as suas características sociodemográficas, socioeconômicas e clínicas. Métodos: Analítico, realizado com 134 cuidadores familiares. Foram incluidos cuidadores maiores de 18 anos e cujos pacientes estavam mais de 12 meses em tratamentos. Foram investigadas dados sociodemográficos e clinicos e utilizado a Escala Burden Interview de Zarit. Para análise foi utilizado média, desvio-padrão, e a sobrecarga de trabalho utilizou-se testes de Mann Whitney e de Kruskall Wallis. Resultados: Participaram da pesquisa 134 cuidadores, sendo a maioria familiares a maioria dos cuidadores familiares era do sexo feminino, entre 30 e 39 anos, casados, filhos dos pacientes, com ensino fundamental completo, sem emprego formal, com renda média de 1 a 2 salários-mínimos. o tempo dispensado ao ato de cuidar de 1 a 3 meses. A sobrecrga foi avaliada  em ausente (44,8%), leve e moderada (41,8%) moderada a severa (12,7%) e intensa (0,7%). Conclusão: Parte dos cuidadores familiares apresentaram sobrecarga, leve a moderada, moderada a severa e intensa.  O sexo, o grau de parentesco, o afastamento das atividades laborais, problema de saúde, uso de medicações e o tempo do adoecimento foram associados à sobrecarga. O apoio e a distribuição de tarefas entre os familiares foram  fundamentais para a redução do nível de sobrecarga.
Letramento em saúde de pessoas em tratamento para hanseníase em município endêmico da região Amazônica
Authors: Da Silva Raquel Gomes , Nogueira Laura Maria Vidal , Dos Santos Marcio Yrochy Saldanha , Rodrigues Ivaneide Leal Ataíde , Pinheiro Ana Kedma Correa , De Farias Sheila Nascimento Pereira
Published: September 2024

Objetivo: Avaliar o Letramento Funcional em Saúde de pessoas em tratamento para hanseníase no contexto amazônico. Método: Estudo quantitativo, observacional, descritivo, desenvolvido com 23 pessoas em tratamento para hanseníase nas unidades municipais de saúde e estratégias saúde da família de dois distritos administrativos de Belém-PA, período março-maio/2023. Utilizou-se o questionário Teste de Letramento em Saúde. Os dados foram inseridos com dupla entrada em banco no Epi-Info 7.2, processados no Statistical Package for the Social Science 28.0 e analisados pela variância e Correlação de Spearman considerando as variáveis sociodemográficas e pontuação obtida no TLS. Foi considerado p-valor ≤ 0,05. Resultados:  Letramento adequado e limitado no sexo masculino, inadequado no feminino e expressivo na cor parda. Pessoas com ensino médio completo apresentaram letramento adequado e com ensino fundamental letramento inadequado. Os adultos apresentaram letramento adequado e idosos letramento inadequado. Identificou-se associação estatística entre o letramento funcional em saúde com o nível de dificuldade para ler embalagem de medicamentos, compreensão acerca das informações escritas, autogerenciamento e empoderamento. Conclusão: Os achados remetem a necessidade de ação de educação em saúde valorizando o perfil das pessoas em tratamento para hanseníase, além de investimento do setor de educação para oferta de escolarização à toda a população.
VIVÊNCIAS COM A GINÁSTICA NA EDUCAÇÃO FÍSICA INFANTIL: UM RELATO DE EXPERIÊNCIA A PARTIR DO ESTÁGIO SUPERVISIONADO
Authors: Silva de Souza Yuri
Published: September 2024

O estágio é componente curricular indispensável para a formação docente, por possibilitar a construção da identidade profissional, além de propiciar a investigação da realidade e a práxis pedagógica. Logo, o objetivo deste estudo foi apresentar o trato do conteúdo ginástica durante o estágio supervisionado da educação física infantil. Trata-se de um estudo descritivo, surgido do relato de experiência do componente curricular Estágio Supervisionado I, do curso de Licenciatura em Educação Física, da Universidade Estadual do Sudoeste da Bahia (UESB), em uma turma de educação infantil, a turma era composta por cinco crianças de três e quatro anos. O estágio foi dividido em três etapas: observação, coparticipação e regência, o conteúdo abordado durante as regências foi a ginástica, por possibilitar aos alunos vivências variadas de sensações e movimentos. Como metodologia principal durante as aulas, destaca-se os jogos cantados que tornou as aulas mais dinâmicas e atrativas, além de trabalhar elementos básicos da ginástica, como os saltos, apoios, giros e equilíbrio, e também a sociabilidade. ademais, trabalhamos com jogos de imitação, principalmente de animais, por tratar de um interesse em comum dos alunos, e a partir da imitação dos animais, conseguimos desenvolver elementos ginásticos. Desse modo, demonstramos a importância de uma prática baseada em estudos, que não leve em consideração apenas o movimento analítico, mas uma prática que possibilite à criança brincar, conviver, explorar os próprios limites e expressar-se.
Alerta vermelho
Authors: Silva Thiago , Prado Marcos Aparecido Rodrigues do
Published: September 2024

Termos como desinformação, fake news e pós-verdade tornaram-se cada vez mais frequentes no dia a dia da sociedade. A Ciência da Informação, que investiga a produção, disseminação e outros fluxos de informação, passou a dar maior atenção a esses tópicos, especialmente após as eleições presidenciais no Brasil. Este estudo teve como objetivo mapear as publicações na Base de Dados Referencial de Artigos de Periódicos em Ciência da Informação (Bracip), utilizando os termos fake news, desinformação e Ciência da Informação no período de 2022 a 2023. Foram encontrados 33 artigos, que foram categorizados após a leitura dos resumos. Os resultados mostram que a maioria dos estudos se concentra no combate à desinformação, abordando temas como competência em informação, competência crítica em informação e mediação, entre outros
Lipids and Inflammation: Novel Molecular Targets and Therapeutic Implications
Authors: Torlai Triglia Laura , GURGOGLIONE FILIPPO LUCA , Barocelli Federico , Bianconcini Michele , Niccoli Giampaolo
Published: September 2024

Atherosclerotic cardiovascular disease represents the most common cause of
death worldwide. Altered cholesterol metabolism and inflammation are major cardiovascular
risk factors that underpin atherosclerotic plaque growth and destabilization. While
initial evidence considered dyslipidemia and inflammation as independent atherogenic
actors, growing evidence has revealed that several molecular mechanisms implicated in
cholesterol metabolism participate in multiple inflammatory signalling pathways. In particular,
proprotein convertase subtilisin/kexin type 9, adenosine monophosphate-activated
protein kinase pathway, oxidized low-density lipoproteins, and lipoprotein (a) have
been demonstrated to share concurrent atherogenic and inflammatory properties. Novel
lipid-lowering therapies targeting these molecular pathways have been implemented.
Mechanistic and clinical studies have addressed their hypolipidemic potential and explored
their role in atherosclerosis-related vascular inflammation, and ongoing randomized
clinical trials are investigating their prognostic role. The purpose of this review
was to dive into the signalling pathways linking cholesterol metabolism and inflammation
and outline the current evidence on the anti-inflammatory activities of the novel
lipid-lowering drugs.
Foam Cells: The Origin of Formation and Target for Plant-derived Bioactive Compounds
Authors: Dabravolski Siarhei A. , Sukhorukov Vasily N. , Glanz Victor Y. , Pleshko Elizaveta M. , Orekhov Nikolay A. , Orekhov Alexander N.
Published: September 2024

Foam cells play a crucial role in the initiation and progression of atherosclerosis,
a condition marked by the development and growth of plaques that narrow blood vessel
lumens. This narrowing can prevent normal blood flow and, in severe cases, lead to
plaque rupture and blood clot formation, which can cause stroke or myocardial infarction.
The origin of foam cells is diverse, arising from monocytes, vascular smooth muscle
cells, stem/progenitor cells, and dendritic and endothelial cells. In their attempt to
eliminate excess lipoproteins and cholesterol, foam cells inadvertently contribute to
plaque development and rupture. Cholesterol uptake, efflux, and esterification are the
major processes regulating foam cell formation. Advances in technology, such as the
identification of cell-surface markers for lineage tracing and single-cell RNA sequencing,
have unveiled diverse molecular mechanisms involved in the formation of foam
cells from different origins, offering new insights into plaque formation and potential targets
for anti-foam cell therapies. In this review, we focus on recent studies exploringthe
inhibitory effects of medicinal plants and their bioactive components on foam cell formation.
Various mechanisms are explored, including the inhibition of cholesterol uptake
and the up-regulation of cholesterol efflux, as well as the suppression of inflammatory
and adhesion activities. Emphasizing a cellular target-based therapeutic approach, this review
envisions the development of innovative plant-based medications for atherosclerosis
treatment.
Enhanced Therapeutic Potential of Liposome-Coated Bushen Jianpi Recipe for Hepatocellular Carcinoma
Authors: Feng Siqi , Zhong Yi , Li Yabin , Li Shiying , Li Yun , Zhou Zhangjie , Wu Zhonghua , Wu Tingting
Published: September 2024

Objective:

Hepatocellular carcinoma (HCC) poses a major healthcare burden globally.
Traditional Chinese medicine formula Bushen Jianpi (BSJP) recipe shows inhibitory effects on HCC
but suffers from low bioavailability. This study aims to develop a BSJP-loaded liposome
(BSJP@Lip) for targeted HCC treatment.

Methods:

BSJP@Lip was prepared using a microfluidic device. Particle characterization included
size, morphology, drug loading, encapsulation efficiency, and release kinetics analysis. In vitro cytotoxicity,
cellular uptake, apoptosis, and protein expression were evaluated in hepG2, Smmc-7721,
and hepa 1-6 hepatic cancer cell lines treated with BSJP@Lip.

Results:

BSJP@Lip nanoparticles showed a uniform spherical shape with an average size of 50 nm
and zeta potential at around -2.24 mV. They significantly inhibited cell viability and induced apoptosis
in a dose-dependent manner compared with traditional decoction formulations. Enhanced cellular
uptake of BSJP@Lip increased the expression of proinflammatory factors IL-18 and NLRP3.

Conclusion:

BSJP@Lip nanoparticles were found to be efficiently internalized by hepatic cancer cell
lines, resulting in a dose-dependent inhibition of cell viability and induction of apoptosis. This effect
was accompanied by the upregulation of IL-18 and NLRP3.
Machine Learning to Differentiate Malignant and Non-malignant Pleural
Effusion Findings
Authors: Guassu Raissa A.C. , Alvarez Matheus , Reis Tarcísio. A. , Ximenes Aglaia. M. G. , Aguiar Ivana. T. , Hasimoto Erica. N. , Junior Raul. L. R. , de Pina Diana Rodrigues
Published: September 2024

Introduction:

This study developed a method using machine learning techniques to differentiate between malignant and non-malignant pleural effusions, analyzing texture parameters
in computed tomography scans

Method:

The study involved forty-one patients, with their computed tomography examinations
classified into three groups: True Positive - patients with both cytopathological analysis and pleural biopsy indicating malignancy; True Negative - patients with negative results in both tests; and
False Negative - patients with negative cytopathological analysis but positive pleural biopsy results. Four machine learning methods were applied across three analyses: True Positive versus
True Negative, True Positive versus False Negative, and True Negative versus False Negative.
The logistic regression model demonstrated notable effectiveness, achieving an Area Under the
Curve of 0.84 ± 0.02 in the True Positive versus True Negative analysis and 0.81 ± 0.05 in the
True Positive versus False Negative comparison. In the True Negative versus False Negative analysis, the Naive Bayes model achieved an Area Under the Curve of 0.72 ± 0.02.

Results:

Statistically significant differences were observed in the liquid Lactate Dehydrogenase
and protein content between the True Positive and True Negative groups (p-values of 0.0390 and
0.0249, respectively), and in the liquid pH level between the True Positive and False Negative
groups (p-value of 0.0254). The use of textural features in combination with machine learning
techniques provided a reliable classification for investigating suspected pleural effusion findings.
This method represents a potential tool for assisting in clinical diagnosis and decision-making, enhancing the accuracy of pleural effusion assessments

Conclusion:

In conclusion, our approach not only improves diagnostic accuracy but also offers a
faster and non-invasive alternative, significantly benefiting clinical decision-making and patient
care.
Phenolic Profile and Antioxidant Capacity of Skin-contact White Wines
Authors: Ramírez-Rodrigues Milena M. , Pérez-Alva Alexa , García-Torres Rosalía
Published: September 2024

Background:

Skin-contact white wines (also known as amber, orange, or macerated
white wines) go through extended maceration during fermentation, giving the wine a characteristic
amber- or orange-like color and a unique flavor.

Objective:

This study aimed to compare the polyphenolic profile and antioxidant capacity of selected
skin-contact white wines from three different regions including the ones prepared with the
traditional Kakhetian method.

Methods:

Samples consisted of nine commercially available skin-contact white wines from
Greece, United States and Georgia. Wines from Georgia were prepared with the traditional Kakhetian
method. Several physicochemical properties, total phenolic content (TPC), ß-carotene, and
mineral content were determined.

Results:

TPC ranged from 447 to 2211 mg GAE/L, antioxidant capacity measured using ABTS
and DPPH ranged from 643 – 2088 μmol TE/L, and 584 – 4421 μmol TE/L, respectively. Mn, Ca,
Mg and P content ranged from 3.6 – 18.2 mg/L, 406 - 772 mg/L, 1530 – 2770 mg/L, and 530 –
2200 mg/L, respectively. A Principal Component Analysis (PCA) of the eight phenolic compounds
that were present in more than one wine (gallic acid, vanillic acid, caffeic acid, caftaric
acid, 4-CQA=4-Caffeoylquinic acid, p-coumaric acid, catechin, and epicatechin) identified two
groups of skin-contact wines. Group one included the three amber wines from Georgia (samples 1
to 3) made following the Kakhetian method and one orange wine from the USA (sample 9).
Group two included the remaining samples from the USA (samples 7,8) and the three samples
from Greece (samples 4-6).

Conclusion:

Skin-contact white wines, despite having an extended maceration during fermentation
in common, can be quite different in polyphenol content and antioxidant capacity, perhaps
due to differences in the processing conditions.
Structural Study on the Novel Plasmonic Optical Materials with Copper Selenide Nanoparticles
Authors: Gurin Valerij
Published: September 2024

Background:

Semiconductor-doped materials have been treated actively throughout the last
decades and continue to be of great interest because of the challenges of the features due to various
nanosize effects. Among other semiconductors, copper chalcogenides demonstrate the interesting plasmonic
properties in line with quantum confinement effects provided by the size factor.

Objective:

This study aims to study the structural and optical features of the sol-gel-derived silica glasses
with copper selenide nanoparticles, demonstrating the appearance of the plasmonic light absorption in
the near IR range.

Method:

The samples under study were fabricated through an original sol-gel technique, which realized
the simultaneous synthesis of copper selenide and sintering of mesoporous silica. The copper selenide
glasses were characterized with X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM),
and optical absorption spectroscopy.

Results:

Formation of nanocrystalline Cu2-xSe particles of the size range from 10 nm through 100-150
nm is established with XRD and TEM techniques. The principal optical properties are presented by the
featured absorption in the visible and near-IR ranges. Eg was evaluated for the direct transitions in the
range of 2.10-2.36 eV. The plasmonic resonance in the nanoparticles due to increased carrier concentration
originated by intrinsic deficiency of Cu2-xSe nanoparticles with variable stoichiometry. Its energy
can be controlled by the Cu/Se ratio in the synthesis procedure.

Conclusion:

The silica sol-gel glasses with copper selenide nanoparticles were fabricated and characterized
by XRD and TEM methods, and their optical absorbance spectra were investigated. The principal
optical properties are presented by the featured absorption in the visible and near-IR ranges: the steplike
proper absorption of the semiconductor particles characterized by Eg and the intense near-IR band
is associated with the localized plasmonic resonance in the nanoparticles due to increased carrier concentration.
Nanomaterials in Brain Cancer Management with Special Emphasis on Personalized Therapy
Authors: De Sampriti , Kirtania Moumita Das
Published: September 2024

Nanomaterials engineered for drug delivery penetrate the blood-brain barrier, ensuring
direct access to cancerous cells, including carbon nanodots, liposomes, dendrimers, metallic nanoparticles,
etc. By encapsulating therapeutic agents, nanomaterials enhance their stability and bioavailability,
optimizing treatment efficacy. Furthermore, they enable real-time monitoring of treatment
response, facilitating adjustments as needed. This strategy represents a significant advancement
in oncology, offering a promising avenue for improving outcomes in brain cancer patients
by maximizing therapeutic benefits while minimizing adverse effects. The discovery and development
of novel nanomaterials and drug delivery systems based on nanotechnology are thus interesting
topics for researchers working on the delivery of drugs to the brain and central nervous system.
However, several challenges may be encountered in the development of nanomaterials and
the commercialization of products. Further, the therapeutic outcomes may vary between patients.
Thus, personalized therapy design for the delivery of nanomedicine may be a better option. The integration
of personalized nanoparticle-based therapies holds great potential for transforming the
landscape of brain cancer management, heralding a new era. Personalized therapy utilizing nanomaterials
is revolutionizing brain cancer treatment by targeting tumours with precision while minimizing
systemic toxicity. This approach tailors therapeutic interventions to individual patient profiles,
accounting for tumor heterogeneity and patient-specific responses.
Spinel Nanoferrites: Adsorption and Photocatalysis of Emerging Pollutants
Authors: Prakash Jyoti , Jasrotia Rohit , Suman  , Kotwal Pinki , Himanshi  , Verma Ankit , Kandwal Abhishek , Kumar Pawan , Godara Sachin Kumar
Published: September 2024

In recent years, scientists have been interested in spinel ferrite-based
nanomaterials because of their exceptional characteristics, such as their high saturation
magnetisation (Ms
), excellent chemical stabilities, and huge surface-to-volume ratios.
Spinel nanoferrites for wastewater clean-up are the subject of this chapter, which goes
into great depth. Spinel ferrite has been discussed in detail, along with some of its key
features. Moreover, the synthesis method and structural and magnetic characteristics of
spinel ferrites are also reviewed in this chapter. There has also been a discussion of
conventional wastewater treatment methods and their limitations in handling different
organic and inorganic pollutants. It is possible to remove inorganic and organic
pollutants from wastewater using adsorption and photocatalysis therefore, in view of
this, these methods are addressed in detail. The importance of spinel ferrite
nanoparticles in pollutant degradation of wastewater and its recovery has been
explored. Additionally, it has been discussed how adsorption and photocatalysis can
improve the efficacy of currently used conventional wastewater treatment techniques.
Towards the end, the future scope of spinel nanoferrites for wastewater treatment is
discussed.
Carbonaceous Quantum Dots and Their Application in Environmental Remediation
Authors: Sharma Ekta , Thakur Vaishali , Singh Kulvinder
Published: September 2024

Carbon quantum dots are sp2
/sp3
-hybridized carbon atoms with sizes ranging
from 2-10nm. They are zero-dimensional florescent nanomaterials that are less toxic,
more biocompatible and highly stable in nature. Carbon quantum dots have attracted
the attention of many research groups due to their novel characteristics and have found
several applications in industries. They are used in various scientific fields which
include synthesis and design of inexpensive biological and chemical sensors. Carbon
quantum dots have several uses in optical sensing, bio imaging, bio-sensing,
optoelectronics photovoltaic and photocatalysis because of their superior electronic,
optical, photocatalytic, up-conversion, photoluminescence and light harvesting
properties. Using CQD, a cost-effective and environmentally friendly method of
cleaning up environmental pollutants is introduced. They have lately been employed in
remediation experiments in place of or together with metal semiconductors due to their
optoelectronic features. Recently, the world has been facing serious threats due to
environmental contamination of various kinds, which has become more serious due to
lesser affordable means for treating it. Industrial waste, pesticides, heavy metal ions,
pharmaceutical waste and sewage are some of the commonly observed water
contaminants. Compared to the earlier studied forms of quantum dots, carbonaceous
quantum dots are the most prevalent ones and can be a better option. The goal of this
chapter is to explain the significance of carbonaceous quantum dots in environmental
remediation. In addition, the advantages of carbonaceous quantum dots over
conventional quantum dots, methods for synthesizing carbonaceous quantum dots (top
down and bottom up), their functionalization or doping to improve their selectivity and
sensitivity, their applications in various fields such as sensing, photocatalysis and biosensing have also been reviewed. By adding surface defects or interstitial states
between electron holes, these alterations have a major impact on the optical
characteristics of carbonaceous quantum dots. Additionally, the methods of removal of
pollutants have also been explored by physical, chemical conventional and biological
methods. Lastly, future perspectives and conclusion speculations have been considered.
DRUG INDUCED NEUROPATHY
Authors: Hanum Anisa Syahfitri , Kurniawan Shahdevi Nandar
Published: September 2024

Neuropathy is a painful condition and originates from a variety of etiologies. Many drugs can cause neuropathy, which is known as Drug-Induced Neuropathy (DIN), which is included in iatrogenic cases. These drugs are chemotherapy agents, antimicrobials, cardiovascular drugs, psychotropics, anticonvulsants, etc. Not all neuropathies require pharmacological therapy, but simply stop therapy, and the complaints will improve (reversible). However, there are quite a few DINs with a “coasting" response neuropathy when DIN is stopped. This review synthesizes current clinical concepts regarding mechanisms, drug-induced neuropathy, and treatment options for drug-induced peripheral neuropathy.
EFFICACY OF NON-PHARMACOLOGICAL APPROACHES TO IMPROVE SLEEP QUALITY INDICES IN POST-STROKE INSOMNIA PATIENTS
Authors: Hidayat Shaffana , Veronica Fifi , Amalia Lisda , Goenawan Hanna
Published: September 2024

Background: Post-stroke insomnia (PSI) is a highly prevalent complication of stroke. Clinical manifestations of PSI include non-refreshing, non-restorative sleep quality and short sleep duration, leading to stroke recovery impediment, cognitive, emotional, and daytime dysfunction, and poor quality of life in stroke patients. PSI can be treated with medications, but studies have reported various adverse effects of hypnotic drugs in PSI. Objective: This study explores non-pharmacological treatments for their efficacy to improve sleep quality in PSI patients. Methods: An electronic search in Medline, Google Scholar, Elsevier, Directory of Open Access Journals (DOAJ), and Semantic Scholar was performed to identify studies examining the efficacy of non-pharmacological approaches to PSI. Results: A total of ten studies examining the efficacy of non-pharmacological approaches to PSI were reviewed. The characteristics of PSI patients in these studies comprised the older population typically at several months after suffering commonly from ischemic type stroke. The evaluated treatments are EEG biofeedback, acupuncture, cognitive-behavioral therapy (CBT), light therapy, and repeated transcranial magnetic stimulation (rTMS). All treatments successfully improved sleep quality, insomnia symptoms, and quality of life in stroke patients as assessed by various measurements including PSQI and actigraphy. Only mild adverse events were reported following acupuncture, such as local hematoma and hand numbness. Conclusion: Non-pharmacological approaches can be considered efficacious in improving sleep quality index, insomnia symptoms, and quality of life of PSI patients. Furthermore, they do not cause severe or long-lasting adverse effects, thus deemed safe for stroke patients.
Is the Apple Vision Pro the Ultimate Display? A First Perspective and Survey on Entering the Wonderland of Precision Medicine
Authors: Egger Jan , Gsaxner Christina , Luijten Gijs , Chen Jianxu , Chen Xiaojun , Bian Jiang , Kleesiek Jens , Puladi Behrus
Published: September 2024

At the Worldwide Developers Conference in June 2023, Apple introduced the Vision Pro. The Apple Vision Pro (AVP) is a mixed reality headset; more specifically, it is a virtual reality device with an additional video see-through capability. The video see-through capability turns the AVP into an augmented reality (AR) device. The AR feature is enabled by streaming the real world via cameras on the (virtual reality) screens in front of the user’s eyes. This is, of course, not unique and is similar to other devices, such as the Varjo XR-3 (Varjo Technologies Oy). Nevertheless, the AVP has some interesting features, such as an inside-out screen that can show the headset wearer’s eyes to “outsiders,” and a button on the top, called the “digital crown,” that allows a seamless blend of digital content with the user’s physical space by turning it. In addition, it is untethered, except for the cable to the battery, which makes the headset more agile, compared to the Varjo XR-3. This could actually come closer to “The Ultimate Display,” which Ivan Sutherland had already sketched in 1965. After a great response from the media and social networks to the release, we were able to test and review the new AVP ourselves in March 2024. Including an expert survey with 13 of our colleagues after testing the AVP in our institute, this Viewpoint explores whether the AVP can overcome clinical challenges that AR especially still faces in the medical domain; we also go beyond this and discuss whether the AVP could support clinicians in essential tasks to allow them to spend more time with their patients.
Development of a Social Communication Intervention Application for Adolescents with ASD and SCD: Protocol for a Pilot Clinical Trial (Preprint)
Authors: Joung Yoo-Sook , Lee Enn Young , Cho Sung Ja , Ju Ran , Kim Hyun Jae , Choi Tae Young , Yoo Jae Hyun
Published: September 2024

BACKGROUND

Autism spectrum disorder (ASD) and social communication disorder (SCD) are characterized by deficits in social communication that hinder social adaptation, with limited pharmacologic options for therapy due to the absence of identified biomarkers.

OBJECTIVE

Recognizing the need for accessible and cost-effective interventions, we developed the digital therapeutic NDTx-01, integrating cognitive behavioral therapy principles, story-based interventions, and gamification elements.

METHODS

This study introduces a protocol for evaluating the efficacy and safety of NDTx-01 through a multicenter, prospective, randomized, assessor-blinded pilot trial involving adolescents aged 1018 years. Participant recruitment and enrollment will be executed in three major medical hospitals, where inter-reliability will be managed by the study team. Enrolled participants, divided into intervention and control groups, will undergo a 6-week intervention with NDTx-01 and usual care or maintain usual care, respectively. The intervention, implemented by NDTx-01, will be structured to last for 6 weeks, with sessions of approximately 10 minutes daily, 5 days a week. Following this, data analysis, including frequency analysis, descriptive statistical analysis, and tests for within-group and between-group differences, will be undertaken.

RESULTS

As of August 2024, we enrolled 39 patients, and this clinical trial has been successfully completed.

CONCLUSIONS

Anticipated results, to be published in April 2024, aim to contribute crucial insights into the effectiveness of digital therapeutics as interventions for ASD and SCD in adolescents.
Faktor-faktor yang Memengaruhi Behavioral Intention untuk Menggunakan TikTok Shop Pada Gen-Z
Authors: Kumalasari Vita , Sumiyana Sumiyana
Published: September 2024

Fenomena yang terjadi di Indonesia adalah semakin meningkat jumlah pengguna internet dalam menggunakan layanan marketplace sehingga membuat persaingan antara marketplace satu dan lainnya. Berbagai jenis marketplace seperti Shopee, Tokopedia, Lazada, dan TikTok Shop. Sejak tahun 2020, Tiktok Shop adalah marketplace yang mengalami peningkatan secara pesat dengan berbagai keuntungan seperti gratis ongkir, harga lebih murah dan lebih menyenangkan karena melihat konten review dengan video unik dan kreatif melalui FYP. Penelitian ini dilakukan untuk mengidentifikasi faktor-faktor yang mampu mempengaruhi niat dan kepercayaan generasi Z untuk menggunakan TikTok Shop sebagai sarana dalam belanja online. Penelitian ini menggunakan kuesioner dengan metode purposive sampling terhadap responden yaitu generasi Z yang menggunakan TikTok namun belum pernah menggunakan TikTok Shop. Sebanyak 173 data dianalisis dengan menggunakan SEM-PLS. Hasil penelitian ini menunjukkan bahwa pengaruh sosial, potensi motivasi hedonis dan kepercayaan memiliki pengaruh yang signifikan terhadap niat perilaku untuk menggunakan TikTok Shop. Penelitian ini dimanfaatkan oleh manajerial TikTok Shop untuk berinovasi dan memfasilitasi fitur yang memudahkan pengguna.
Evaluasi Implementasi Sistem Informasi Manajemen dan Akuntansi Barang Milik Negara (Studi Kasus pada Satuan Kerja Mitra KPKNL Jakarta II)
Authors: Yasser Arafat Amal Akbar , Halim Abdul
Published: September 2024

Penelitian ini bertujuan untuk mengevaluasi implementasi Sistem Informasi Manajemen dan Akuntansi Barang Milik Negara (SIMAK BMN) yang diindikasikan kurang berhasil dalam pencatatan dan pelaporan aset tetap menggunakan sudut pandang pengguna SIMAK BMN. SIMAK BMN merupakan sistem informasi yang bersifat wajib yang digunakan oleh pengguna barang di tingkat satuan kerja untuk mencatat dan melaporkan BMN dalam rangka pengelolaan BMN dan penyusunan laporan keuangan. Evaluasi atas SIMAK BMN dilakukan berdasarkan model kesuksesan sistem informasi DeLone dan McLean. Data sumber yang digunakan dalam penelitian ini berupa hasil wawancara dengan pengguna SIMAK BMN pada Satuan Kerja Mitra Kantor Pelayanan Kekayaan Negara dan Lelang (KPKNL) Jakarta II. Wawancara dilakukan untuk menggali kelemahan-kelemahan dalam implementasi SIMAK BMN berdasarkan pengalaman pengguna dalam menggunakan SIMAK BMN. Berdasarkan hasil evaluasi, terdapat kelemahan pada kualitas sistem SIMAK BMN, kualitas informasi yang dihasilkan SIMAK BMN dan kualitas layanan unit pendukung SIMAK BMN. Selain itu, terdapat pula kelemahan lain yaitu kurangnya pelatihan yang memadai dan kurangnya dukungan top manajemen kepada pengguna SIMAN BMN. Kelemahan-kelemahan tersebut menjadi penyebab kurang berhasilnya SIMAK BMN dalam pencatatan dan pelaporan aset tetap.