bluuebunny/crossref_metadata_2025 huggingface dataset:
ZnONR Microstructure Modification and their Potential for High Reversibillity Performance of AC-Mn2O3 Supercapacitor
Authors: Diantoro Markus , Luthfiyah Ishmah , Wisodo Hari , Utomo Joko , Meevasana Worawat
Published: December 2023

One of Indonesia's most significant issues with technological growth is the lack of electrical energy storage devices. Active materials have low electrical conductivity, accessibility, and ion diffusion. Therefore, it is urgently required to study the combination of higher electrical conductivity ZnO and high surface area of AC-Mn2O3. However, ZnO nanorods (ZnONR) can be modified from ZnO nanoparticles (ZnONP). The structure modification may increase energy density due to having a higher surface area than ZnONP. Three different electrodes with AC-Mn2O3 addition various spin coated of 1000 rpm (MZnONR1), 2500 rpm (MZnONR2), and 3000 rpm (MZnONR3). The electrodes were then packaged in a sandwich flat symmetric supercapacitor. The characterization was carried out using X-RD, SEM-EDX cross-section, FTIR, and Cyclic Voltammetric. It is obtained that the highest specific capacitance showed by symmetric supercapacitor MZnONR1 with low speed of spin coating. We also found that the greater the deposited ZnNR content, the lowest thickness until 43.76 μm, the crystallinity until 62% and the highest porosity until 79%. This shows that the MZnONR1 sample exhibits the best electrochemical performance, which is supported by its morphological properties. It is shown that the higher the Zn content, the stability performance AC-Mn2O3 supercapacitor higher. ZnONR1 sandwich flat symmetric supercapacitor have a specific capacitance 0.0086 Fg-1 with an 0.00433 Whg-1 energy density. Furthermore, it was found that the addition of the AC-Mn2O3 increased 2800x compared to the ZnONR1, which reached 28.04 Fg-1 and an 14.09 Whg-1 of capacitance specific and energy density, respectively.
The relationship between mental workload and nurse stress levels in hospitals
Authors: Fikri Zahid , Bellarifanda Adelia , Sunardi Sunardi , ‘Ibad Muhammad Rosyidul , Mu’jizah Khikmatul
Published: December 2023

High mental workload implies significant mental resources and can lead to increased cognitive stress and fatigue. Nurses have the responsibility of managing a wide range of nursing care tasks, which frequently involve addressing anxiety, handling patient complaints, and managing patient defense mechanisms, all of which can lead to increased stress levels. This study aimed to identify the relationship between mental workload and the stress level of nurses in the Hospital Malang City. The research utilized a cross-sectional study design. The sampling technique employed was Total Sampling, involving 96 inpatient nurses at the hospital. Data collection involved the use of two questionnaires: the National Aeronautics and Space Administration Task Load Index (NASA-TLX) and the Perceived Stress Scale (PSS-10). Data analysis in this study was conducted using Pearson Correlation. The results indicated a positive relationship between mental workload and nurses' stress levels, supported by a significant p-value of 0.002 and a correlation coefficient of 0.312. A high mental workload can impact the level of job-related stress experienced by nurses. Effective stress management skills can help individuals mitigate this impact.
Esperienza del team vulnologico ai tempi del COVID-19
Authors: Abd el khalek Sabrin , Balduzzi Ersilia , Costamagna Graziella , Donascimento Alexandra , Martin Fabrizio Lorenzo Luca , Stuardi Maddalena , Piazza Salvatore
Published: December 2023

La pandemia di Coronavirus (COVID-19) ha aumentato in modo significativo il ricovero di pazienti prevalentemente a causa delle complicanze respiratorie, in particolar modo nelle unità di terapia intensiva. Durante la prima ondata i pazienti COVID-19 presentavano un numero maggiore di lesioni da pressione (LDP) acquisite in ospedale, rispetto ai pazienti non COVID-19. La fragilità di questi pazienti, le manovre necessarie al loro supporto respiratorio e l’utilizzo di numerosi dispositivi medici sono le motivazioni principali dell’elevato rischio di perdita dell’integrità cutanea. L’insorgenza di lesioni cutanee ha come conseguenze un aumento della degenza, dei costi relativi all’assistenza e, non meno importante, un impatto negativo sulla qualità di vita dei pazienti. Alla luce di tali premesse, il team vulnologico infermieristico dell’Ospedale HUB Mauriziano di Torino, nel periodo pandemico, ha pianificato ed effettuato un intervento di prevenzione/trattamento delle lesioni cutanee e di supporto degli operatori sanitari impegnati nell’assistenza ai pazienti COVID-19 nei reparti dell’ospedale. L’attività è stata svolta nel periodo dal 30/10/2020 al 30/04/2021. Nello studio sono stati arruolati 679 pazienti. In 361 pazienti (53,2%) sono state effettuate esclusivamente attività di tipo preventivo, 343 (95%) di questi pazienti non hanno sviluppato alcuna lesione. L’età, la durata del ricovero e il punteggio di Braden sono stati i fattori più rilevanti nei pazienti con LDP acquisite. In 318 (46,8%) pazienti, oltre ad interventi preventivi, sono stati effettuati trattamenti di lesioni preesistenti, in questo campione in 28 (8,8%) dei casi si è registrato un peggioramento delle lesioni. Infine, la quasi totalità degli operatori, 113 su 118 (96%), ha riconosciuto l’utilità del supporto degli specialisti in Wound Care attraverso la compilazione di un questionario online.
Use of laser for uncovering a mandibular retained tooth: case report
Authors: Wang Huichao , Li Yupu , Zhao Ting , Sun Ruonan , Rocca Jean-Paul , Fornaini Carlo
Published: December 2023

This clinical study aimed to describe a case of lower impacted canine to demonstrate the advantages of diode laser for crown exposure during orthodontic treatment. The patient received a surgical intervention by an infra-red diode laser to uncover a retained lower canine. The intervention did not need anesthetic injection and suture apposition, the patient did not refer pain, and the healing process was completed after a week. The diode laser was safe, fast, and easy to use, and the avoidance of bleeding was reached due to its excellent absorption by hemoglobin: this is particularly important considering that, for obtaining a strong adhesion, a bracket must be bonded in a dry enamel surface. The use of an infrared diode laser is a proper approach in the surgery of retained teeth during orthodontic treatment.
Roles of neuronal lysosomes in the etiology of Parkinson's disease
Authors: Volta Mattia
Published: December 2023

Therapeutic progress in neurodegenerative conditions such as Parkinson's disease has been hampered by a lack of detailed knowledge of its molecular etiology. The advancements in genetics and genomics have provided fundamental insights into specific protein players and the cellular processes involved in the onset of disease. In this respect, the autophagy-lysosome system has emerged in recent years as a strong point of convergence for genetics, genomics, and pathologic indications, spanning both familial and idiopathic Parkinson's disease. Most, if not all, genes linked to familial disease are involved, in a regulatory capacity, in lysosome function (e.g., LRRK2, alpha-synuclein, VPS35, Parkin, and PINK1). Moreover, the majority of genomic loci associated with increased risk of idiopathic Parkinson's cluster in lysosome biology and regulation (GBA as the prime example). Lastly, neuropathologic evidence showed alterations in lysosome markers in autoptic material that, coupled to the alpha-synuclein proteinopathy that defines the disease, strongly indicate an alteration in functionality. In this Brief Review article, I present a personal perspective on the molecular and cellular involvement of lysosome biology in Parkinson's pathogenesis, aiming at a larger vision on the events underlying the onset of the disease. The attempts at targeting autophagy for therapeutic purposes in Parkinson's have been mostly aimed at “indiscriminately” enhancing its activity to promote the degradation and elimination of aggregate protein accumulations, such as alpha-synuclein Lewy bodies. However, this approach is based on the assumption that protein pathology is the root cause of disease, while pre-pathology and pre-degeneration dysfunctions have been largely observed in clinical and pre-clinical settings. In addition, it has been reported that unspecific boosting of autophagy can be detrimental. Thus, it is important to understand the mechanisms of specific autophagy forms and, even more, the adjustment of specific lysosome functionalities. Indeed, lysosomes exert fine signaling capacities in addition to their catabolic roles and might participate in the regulation of neuronal and glial cell functions. Here, I discuss hypotheses on these possible mechanisms, their links with etiologic and risk factors for Parkinson's disease, and how they could be targeted for disease-modifying purposes.
The advantages of multi-level omics research on stem cell-based therapies for ischemic stroke
Authors: Wang Yiqing , Chang Chuheng , Wang Renzhi , Li Xiaoguang , Bao Xinjie
Published: December 2023

Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However, despite many years of preclinical research, the application of stem cells is still limited to the clinical trial stage. Although stem cell therapy can be highly beneficial in promoting functional recovery, the precise mechanisms of action that are responsible for this effect have yet to be fully elucidated. Omics analysis provides us with a new perspective to investigate the physiological mechanisms and multiple functions of stem cells in ischemic stroke. Transcriptomic, proteomic, and metabolomic analyses have become important tools for discovering biomarkers and analyzing molecular changes under pathological conditions. Omics analysis could help us to identify new pathways mediated by stem cells for the treatment of ischemic stroke via stem cell therapy, thereby facilitating the translation of stem cell therapies into clinical use. In this review, we summarize the pathophysiology of ischemic stroke and discuss recent progress in the development of stem cell therapies for the treatment of ischemic stroke by applying multi-level omics. We also discuss changes in RNAs, proteins, and metabolites in the cerebral tissues and body fluids under stroke conditions and following stem cell treatment, and summarize the regulatory factors that play a key role in stem cell therapy. The exploration of stem cell therapy at the molecular level will facilitate the clinical application of stem cells and provide new treatment possibilities for the complete recovery of neurological function in patients with ischemic stroke.
The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types
Authors: Xu Hongye , Li He , Zhang Ping , Gao Yuan , Ma Hongyu , Gao Tianxiang , Liu Hanchen , Hua Weilong , Zhang Lei , Zhang Xiaoxi , Yang Pengfei , Liu Jianmin
Published: December 2023

Astrocytes are the most abundant glial cells in the central nervous system; they participate in crucial biological processes, maintain brain structure, and regulate nervous system function. Exosomes are cell-derived extracellular vesicles containing various bioactive molecules including proteins, peptides, nucleotides, and lipids secreted from their cellular sources. Increasing evidence shows that exosomes participate in a communication network in the nervous system, in which astrocyte-derived exosomes play important roles. In this review, we have summarized the effects of exosomes targeting astrocytes and the astrocyte-derived exosomes targeting other cell types in the central nervous system. We also discuss the potential research directions of the exosome-based communication network in the nervous system. The exosome-based intercellular communication focused on astrocytes is of great significance to the biological and/or pathological processes in different conditions in the brain. New strategies may be developed for the diagnosis and treatment of neurological disorders by focusing on astrocytes as the central cells and utilizing exosomes as communication mediators.
Application of artificial hibernation technology in acute brain injury
Authors: Wang Xiaoni , Chen Shulian , Wang Xiaoyu , Song Zhen , Wang Ziqi , Niu Xiaofei , Chen Xiaochu , Chen Xuyi
Published: December 2023

Controlling intracranial pressure, nerve cell regeneration, and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury. There is currently a lack of effective treatment methods. Hibernation has the characteristics of low temperature, low metabolism, and hibernation rhythm, as well as protective effects on the nervous, cardiovascular, and motor systems. Artificial hibernation technology is a new technology that can effectively treat acute brain injury by altering the body's metabolism, lowering the body's core temperature, and allowing the body to enter a state similar to hibernation. This review introduces artificial hibernation technology, including mild hypothermia treatment technology, central nervous system regulation technology, and artificial hibernation-inducer technology. Upon summarizing the relevant research on artificial hibernation technology in acute brain injury, the research results show that artificial hibernation technology has neuroprotective, anti-inflammatory, and oxidative stress-resistance effects, indicating that it has therapeutic significance in acute brain injury. Furthermore, artificial hibernation technology can alleviate the damage of ischemic stroke, traumatic brain injury, cerebral hemorrhage, cerebral infarction, and other diseases, providing new strategies for treating acute brain injury. However, artificial hibernation technology is currently in its infancy and has some complications, such as electrolyte imbalance and coagulation disorders, which limit its use. Further research is needed for its clinical application.
Human brain organoid: trends, evolution, and remaining challenges
Authors: Li Minghui , Yuan Yuhan , Hou Zongkun , Hao Shilei , Jin Liang , Wang Bochu
Published: December 2023

Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases. Although various studies and reviews have described developments and advancements in brain organoids, few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience. To identify and further facilitate the development of cerebral organoids, we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years. First, annual publications, countries/regions, organizations, journals, authors, co-citations, and keywords relating to brain organoids were identified. The hotspots in this field were also systematically identified. Subsequently, current applications for brain organoids in neuroscience, including human neural development, neural disorders, infectious diseases, regenerative medicine, drug discovery, and toxicity assessment studies, are comprehensively discussed. Towards that end, several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.
Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming
Authors: Papadimitriou Elsa , Thomaidou Dimitra
Published: December 2023

Neurogenesis is a tightly regulated process in time and space both in the developing embryo and in adult neurogenic niches. A drastic change in the transcriptome and proteome of radial glial cells or neural stem cells towards the neuronal state is achieved due to sophisticated mechanisms of epigenetic, transcriptional, and post-transcriptional regulation. Understanding these neurogenic mechanisms is of major importance, not only for shedding light on very complex and crucial developmental processes, but also for the identification of putative reprogramming factors, that harbor hierarchically central regulatory roles in the course of neurogenesis and bare thus the capacity to drive direct reprogramming towards the neuronal fate. The major transcriptional programs that orchestrate the neurogenic process have been the focus of research for many years and key neurogenic transcription factors, as well as repressor complexes, have been identified and employed in direct reprogramming protocols to convert non-neuronal cells, into functional neurons. The post-transcriptional regulation of gene expression during nervous system development has emerged as another important and intricate regulatory layer, strongly contributing to the complexity of the mechanisms controlling neurogenesis and neuronal function. In particular, recent advances are highlighting the importance of specific RNA binding proteins that control major steps of mRNA life cycle during neurogenesis, such as alternative splicing, polyadenylation, stability, and translation. Apart from the RNA binding proteins, microRNAs, a class of small non-coding RNAs that block the translation of their target mRNAs, have also been shown to play crucial roles in all the stages of the neurogenic process, from neural stem/progenitor cell proliferation, neuronal differentiation and migration, to functional maturation. Here, we provide an overview of the most prominent post-transcriptional mechanisms mediated by RNA binding proteins and microRNAs during the neurogenic process, giving particular emphasis on the interplay of specific RNA binding proteins with neurogenic microRNAs. Taking under consideration that the molecular mechanisms of neurogenesis exert high similarity to the ones driving direct neuronal reprogramming, we also discuss the current advances inin vitroandin vivodirect neuronal reprogramming approaches that have employed microRNAs or RNA binding proteins as reprogramming factors, highlighting the so far known mechanisms of their reprogramming action.
A Preliminary Study on Anti-Colorectal Cancer Effect and Molecular Mechanism of Aegiceras Corniculatum Extract
Authors: Tan De-Chao , Hou Xiao-Tao , Luo Hua , Chen Yi-Wei , Du Zheng-Cai , Xie Jin-Ling , Wei Lin-Yao , Vong Chi-Teng , Wen Xiao-Yan , Hao Er-Wei , Deng Jia-Gang
Published: December 2023

Objective:

To study the inhibitory effects on colorectal cancer (CRC) and the underlying mechanism of the petroleum ether extract of Aegiceras corniculatum leaves (PACL).

Materials and Methods:

The effect of PACL on the proliferation of CRC cell lines DLD-1, HT-29, and SW480 was measured by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay and colony-forming assay. And then, a wound-healing assay was used to measure the migration ability of three CRC cells. The cell cycle and apoptosis of three CRC cells were measured by PI/RNase staining and annexin V-FITC/double staining, respectively, and the intrinsic apoptosis pathway was studied by the Western blot. The anti-CRC effect of PACL in vivo was evaluated by HT-29 xenograft zebrafish embryos.

Results:

PACL inhibited cell viability and proliferation in DLD-1, HT-29, and SW480 cells in a dose- and time-dependent manner. PACL can inhibit cell migration in DLD-1 and SW480 cells but not in the less mobile phenotype cell HT-29. PACL treatment resulted in cell cycle arrest of DLD-1 and HT-29 cells in the G2/M phase. Moreover, PACL can induce apoptosis in all three CRC cells, which may be achieved by regulating the intrinsic apoptosis pathway mediated by mitochondria and the endoplasmic reticulum. Interestingly, the tumor sizes were decreased after treatment with PACL and PACL combined with fluorouracil in HT-29 xenograft zebrafish embryos.

Conclusions:

These findings suggested that PACL may exert its anti-CRC effect by inducing apoptosis through the intrinsic apoptosis pathway and show a significant anti-CRC effect in vitro and in vivo, so it might be potentially developed as an anti-CRC agent.
Study on the Resolving Phlegm Effect of D-Limonene in Mice with Spleen Deficiency and Phlegm-Dampness Syndrome
Authors: Luo Jie , Wang Long-Jing , Li Yang-Song , Zhang Jin , Zhang Gui-Rong , Long Fei , Peng Teng , Yan Jie , Zhu Bao-Jie
Published: December 2023

Objective:

According to Traditional Chinese Medicine theory, spleen deficiency and phlegm-dampness syndrome (SDPDS) are caused by abnormal water metabolism in the body because of spleen dysfunction. The purpose of this article was to evaluate the efficacy of D-limonene (DL) in resolving phlegm in mice with SDPDS from the perspective of regulating the level of aquaporin 3 (AQP3).

Methods:

The model of SDPDS was induced in mice using the multifactor modeling method, which combines internal and external dampness. An artificial climate box was used to create a humid environment, whereas the irregular diet was caused by different feeding methods on odd-even days. The mice were divided into blank control, model group, DL low-dose, DL high-dose, and positive groups. The mice were modeled and treated for 7 day. Levels of gastrin and amylase (AMS) in the serum, mucus secretion in the trachea, and AQP3 in the tissue near the gastric cardia.

Results:

DL significantly reduced mucus secretion in the trachea (P < 0.001). It also increased the level of AMS in the serum (P < 0.01) and decreased the level of AQP3 in the gastric tissue (P < 0.01).

Conclusions:

Mice with SDPDS exhibited disturbed water metabolism and significantly increased AQP3 levels. DL can restore the levels of AQP3 and plays an important role in resolving phlegm. This study may also help expand the efficacy of natural drugs containing DL and improve the utilization of natural drug resources.
P16 and EGFR analyses in cervical carcinoma on paraffin material in Egyptian females: the NCI experience
Authors: Badawy Omnia , Loay Iman , Negmaldin Dalia
Published: December 2023

Introduction

Cervical cancer is considered the fourth most prevalent malignant tumor in women worldwide. In Egypt, it ranks as the 14th most frequent cancer among women. Epidermal growth factor receptor has been an attractive target for anticancer therapy. Although EGFR mutations are less commonly seen in cervical cancer, there is a potential correlation between EGFR expression level and clinical response. Overexpression of p16INK4a is associated with increased overall and disease-free survival in cervical cancer, thus denoting a better prognosis.

Aim of the work

To investigate the expression of EGFR and p16 by immunohistochemistry as well as amplification of EGFR by FISH technique in cervical carcinoma among Egyptian females.

Material and methods

Seventy-seven cases of invasive cervical carcinomas were retrieved from paraffin blocks. EGFR and p16 expression were assessed by immunohistochemistry. EGFR gene amplification was assessed by FISH analysis.

Results

p 16 Positivity was detected in 62.3% of cases. Positive reaction to EGFR (score 3+) was detected in 20.8% of cases. The EGFR gene was not amplified in 77.9% of cases. Statistical significance was found between histological type, p16, and EGFR expression. A fair agreement was detected between EGFR expression and EGFR amplification. Poor agreement was detected between p16, EGFR expression, and EGFR amplification.

Conclusion

EGFR and p16 have an independent role in the development of cervical cancer in Egyptian females. EGFR overexpression and EGFR amplification represent two different genetic events; in other words, an increase in gene copy number does not mean that there will be an increase in the function of the gene as expressed by an increase in protein expression.
Cortactin expression in muscle-invasive and nonmuscle-invasive urinary bladder carcinoma in patients live in Sohag City, Egypt
Authors: Mohammed Maisa H , El-Wahab Atef GA , Ahmed Sheren FM
Published: December 2023

Background

Bladder carcinoma (BC) is the ninth most prevalent cancer worldwide. However, it represents the most frequently occurring cancer in Egypt, where infection by Schistosoma haematobium is an endemic health problem. BCs are clinically subdivided into different stages according to invasion of the muscle layer and distant metastasis. Invasion of the surrounding tissues and metastasis are characteristic issues in malignant tumors. Malignant cells rearrange the intracellular actin filaments in the form of an assembly of branched network in the direction of cell movement. The well-formed actin assembly must be anchored by an adhesive-like protein named cortactin (CTTN). CTTN overexpression has been detected in various human malignant neoplasms. The aim of this study was to evaluate the expression of CTTN in BC and to correlate such expression with different parameters such as depth of invasion, nodal metastasis, and bilharzial infestation.

Patients and methods

The current study enrolled 66 patients with BCs. Formalin-fixed and paraffin-embedded tissue blocks were prepared from each specimen. Hematoxylin and eosin tissue sections were prepared to confirm the diagnosis of BCs, determine tumor phenotype, assess degree of invasion, and detect any evidence of bilharzial infestation. Corresponding tissue sections were stained by antihuman CTTN antibody using the immunohistochemical approach.

Results

Overexpression of CTTN was associated with muscle invasion by neoplastic cells (P<0.001), advanced pathological T category (P=0.002), and presence of metastatic deposits in the regional lymph nodes (P<0.001).

Conclusion

Overexpression of CTTN in BC is associated with increased tumor invasion and nodal metastasis.
Sentence Fusion using Deep Learning
Authors: Roy Chowdhury Sohini , Sarkar Kamal
Published: December 2023

The human process of document summarization involves summarizing a document by sentence fusion. Sentence fusion combines two or more sentences to create an abstract sentence. Sentence fusion is useful to convert an extractive summary to an abstractive summary. The extractive summary contains a set of salient sentences selected from a single document or multiple related documents. Redundancy creates problems while creating an extractive summary because it contains sentences whose segments or phrases are redundant. Sentence fusion helps to remove redundancy by fusing sentences into a single abstract sentence. This moves an extractive summary to an abstractive summary. In this paper, we present an approach that uses a deep learning model for sentence fusion. which is trained over a large dataset. We have tested our approach through both manual evaluation and system evaluation. The result of our proposed approach shows that our model is good enough to fuse sentences effectively.
Bimodule coefficients, Riesz transforms on Coxeter groups and strong solidity
Authors: Borst Matthijs , Caspers Martijn , Wasilewski Mateusz
Published: December 2023

In deformation-rigidity theory, it is often important to know whether certain bimodules are weakly contained in the coarse bimodule. Consider a bimodule

H

over the group algebra

\mathbb{C}[\Gamma]

with

\Gamma

a discrete group. The starting point of this paper is that if a dense set of the so-called coefficients of

H

is contained in the Schatten

\mathcal{S}_{p}

class

p \in [2, \infty)

, then the

n

-fold tensor power

H^{\otimes n}_{\Gamma}

for

n \geq \frac{p}{2}

is quasi-contained in the coarse bimodule. We apply this to gradient bimodules associated with the carré du champ of a symmetric quantum Markov semi-group. For Coxeter groups, we give a number of characterizations of having coefficients in

\mathcal{S}_{p}

for the gradient bimodule constructed from the word length function. We get equivalence of: (1) the gradient-

\mathcal{S}_{p}

property introduced by the second named author, (2) smallness at infinity of a natural compactification of the Coxeter group, and for a large class of Coxeter groups, (3) walks in the Coxeter diagram called parity paths. We derive several strong solidity results. In particular, we extend current strong solidity results for right-angled Hecke von Neumann algebras beyond right-angled Coxeter groups that are small at infinity. Our general methods also yield a concise proof of a result by Sinclair for discrete groups admitting a proper cocycle into a

p

-integrable representation.
Potential therapeutic targets for the prevention of diabetic nephropathy: Glycyrrhetinic acid
Authors: Cai Lu , Horowitz Michael , Islam Md Shahidul
Published: December 2023

Uncontrolled hyperglycemia or poorly managed disease increases the propensity for a number of diabetes-related complications targeting major organs including the heart, eyes, and kidney. Although the mechanisms by which diabetes induces cardiovascular diseases include oxidative stress and inflammation, when insulin resistance remains the key to the pathogenesis, as implicated in the two reviews in this issue. This editorial mainly comments on the potential preventive application of glycyrrhetinic acid (or 18β-GA) in relation to diabetic nephropathy. The thera-peutic or preventive effects of 18β-GA, as a hydrolytic product of glycyrrhizic acid that is a component of licorice, have been appreciated in other disorders, but have received much less attention in relation to diabetic complications. A study in this issue has identified 18β-GA as a therapeutic for preventing diabetic nephropathy and provides evidence to support efficacy in cultured human renal tubule cells in vitro . Although it represents a pilot study, the observations support a new therapeutic approach that warrants further ex-ploration.
Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations
Authors: Tang Ling-Tong , Feng Lei , Cao Hui-Ying , Shi Rui , Luo Bei-Bei , Zhang Yan-Bi , Liu Yan-Mei , Zhang Jian , Li Shuang-Yue
Published: December 2023

BACKGROUND

The global prevalence of type 2 diabetes mellitus (T2DM) is increasing. T2DM is associated with alterations of the gut microbiota, which can be affected by age, illness, and genetics. Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations. However, the specific gut microbiota differences between the two populations have not been elucidated.

AIM

To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.

METHODS

A total of 35 subjects of the Han population (including 15 healthy children, 8 adult healthy controls, and 12 adult T2DM patients) and 32 subjects of the Dai population (including 10 healthy children, 10 adult healthy controls, and 12 adult T2DM patients) were enrolled in this study. Fasting venous blood samples were collected from all the subjects for biochemical analysis. Fecal samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing, which was followed by analyses of the gut microbiota composition.

RESULTS

No significant difference in alpha diversity was observed between healthy children and adults. The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Han population with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, this difference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteria in the Dai population and decreases in Firmicutes in both the Han and Dai population were observed in T2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that the gut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients. Four bacteria were consistently increased and two consistently decreased in the Han population compared to the Dai population.

CONCLUSION

Differences in gut microbiota were found between the Han and Dai populations. A significant increase in Bacteroidetes was related to the occurrence of T2DM in the Han population, while a significant increase in Proteobacteria was related to the occurrence of T2DM in the Dai population.
Aluminum Alloy, Die and Hand Forgings 5.6Zn - 2.5Mg - 1.6Cu - 0.23Cr (7175-T74) Solution and Precipitation Heat Treated
Authors:   AMS D Nonferrous Alloys Committee
Published: December 2023

This specification covers an aluminum alloy in the form of die and hand forgings 6.000 inches (152.00 mm) and under in nominal thickness at time of heat treatment (see 8.6).
Aluminum Alloy, Extruded Profiles (7055-T77511) 8.0Zn - 2.3Cu - 2.0Mg - 0.16Zr Solution Heat Treated, Stress Relieved, and Overaged
Authors:   AMS D Nonferrous Alloys Committee
Published: December 2023

This specification covers an aluminum alloy in the form of extruded profiles (shapes) 0.500 to 1.500 inch (12.7 to 38.1 mm), inclusive, in nominal thickness, and having a maximum cross-sectional area of 20 square inches (129 cm2) and a maximum circle size of 10 inches (254 mm) (see 8.7).
Prognose do risco e previsibilidade do resultado: uma análise a partir do julgado no AgRg-REsp 1.094.758
Authors: Amaral Rodrigo
Published: December 2023

The scope of this article is to analyze, from the case decided in RE 1.094.758, the institute of predictability in the theory of crime. First, the factual details of the res judicata are presented, which generated an indictment for bodily injuries qualified by the death of the victim, and then we move on to the presentation of how the different instances of the Judiciary decided, as well as the reasons for deciding. Next, the specific grounds for the decision are analyzed in order to clarify whether the finding of the unpredictability of a factual element closes the question of risk prognosis. Thereby, it is reflected on the minimum criteria for the analysis of predictability and the arguments contained in the decision that defined the outcome of the case analyzed are scrutinized. At the end, it is also analyzed whether a special condition of the victim not knowable to the agent could be considered in the risk prognosis and whether the analyzed judge could resolve the case by the absence of devaluation of result. It is concluded that the analyzed judgment did not fully analyze the issue of predictability of the result, because the impossibility of predicting that the victim had a disease does not necessarily equate to the conclusion that the outcome was unpredictable.
DETECTION OF ADVANCED PERSISTENT THREATS USING SIEM RULESETS
Authors: ŞİMŞEK Adem , KOLTUKSUZ Ahmet
Published: December 2023

Cyber-attacks move towards a sophisticated, destructive, and persistent position, as in the case of Stuxnet, Dark Hotel, Poseidon, and Carbanak. These attacks are called Advanced Persistent Threats (APTs), in which an intruder establishes an undetected presence in a network to steal sensitive data over a prolonged period. APT attacks threaten the main critical areas of today's digitalized life. This threat covers critical infrastructures, finance, energy, and aviation agencies. One of the most significant APT attacks was Stuxnet, which targeted the software controlling the programmable logic controllers (PLCs) that are, in turn, used to automate machine processes. The other one was the Deep Panda attack discovered in 2015, which compromised over 4 million US personnel records because of the ongoing cyberwar between China and the US. This paper explains the difficulties of detecting APTs and examines some of the research in this area. In addition, we also present a new approach to detecting APTs using the Security Information and Event Management (SIEM) solution. In this approach, we recommend establishing APT rulesets in SIEM solutions using the indicators left behind by the attacks. The three basic indicator types are considered in the rulesets and are examined in detail.
El convento de Capuchinos de Sevilla en el siglo XIX
Authors: González Caballero Alberto
Published: December 2023

Este artículo consta de tres partes: 1. La "Exclaustración de Bonaparte", nombre español de la toma de posesión por el Estado de monasterios y conventos, donde se recogen todas las obras de arte anteriores a la invasión, así como la recuperación del edificio y de todos los "murillos" una vez finalizada la invasión. 2. La 'exclaustración' tras los Tres Años de gobierno liberal. 3. La exclaustración de 1835. Este último periodo se alarga un poco para describir la situación de los frailes que fueron expulsados de sus conventos, así como del propio edificio, y la negociación que siguió hasta su definitiva recuperación y restauración
Diálogos humanistas: Xavier Zubiri y Jean Luc Marion
Authors: Castellón Martín José Joaquín
Published: December 2023

En una época en la que el "pensamiento débil" del posmodernismo intenta desmantelar las bases del comportamiento ético, es muy necesaria una reflexión profunda sobre las ideas de libertad y responsabilidad. No es sólo la "mente" humana la que exige la excelencia moral, sino también la realidad del "ser" humano, en particular de los seres humanos que sufren. Este ensayo se ha escrito como un diálogo entre dos autores contemporáneos
Jesús, el dinero y la riqueza
Authors: Camacho Acosta Fernando
Published: December 2023

En el contexto social y económico del Imperio romano romano, y en particular de Palestina, Jesús, según los Evangelios, hace una crítica lúcida y penetrante del dinero y la riqueza, amonesta sobre los peligros y las consecuencias de de dejarse seducir por ellos, y aconseja a sus seguidores que adopten un que la única fuente de riqueza sea Dios. El comportamiento humano en este sentido debe regirse por la austeridad y el compartir, el cuidado de los demás y la generosidad. Este modo de vida es la garantía de una convivencia social justa y fraternal, y favorecerá la creación de una nueva sociedad
erbal Alternatives for Managing Depression: Mechanisms and Efficacy
Authors: Arvind Abdesh , Rani M Sandhya , Mohan G. Krishna
Published: December 2023

Depressive disorder, commonly known as depression, is a prevalent and often debilitating mental health condition. It is characterized by persistent feelings of sadness, hopelessness, and a loss of interest or pleasure in daily activities. Depression is a leading cause of disability in adults, with treatment options primarily consisting of psychotherapy and pharmaceutical interventions. However, the adverse effects associated with conventional antidepressants can lead to treatment non-adherence in a significant proportion of patients. This paper reviews the symptoms, pathophysiology, diagnosis, and standard treatments for depression, including various classes of antidepressant medications and their associated adverse events. It highlights the urgent need for alternative therapies, particularly in cases where conventional treatment proves ineffective. In recent years, herbal medicines have gained attention as potential options for managing depression. This review explores the therapeutic agents used in the treatment of depression, such as curcumin, carvacrol, resveratrol, ferulic acid, and proanthocyanins. These natural compounds have demonstrated promising antidepressant effects in preclinical studies, with mechanisms of action involving the regulation of the HPA axis, modulation of monoamine neurotransmitters, and promotion of neurogenesis and neurotropic factors. The paper discusses the bioavailability and absorption challenges of these herbal compounds and proposes innovative delivery methods to enhance their effectiveness. For instance, buccal delivery has shown promise in increasing the absorption of resveratrol, improving its bioavailability. In conclusion, this review emphasizes the growing body of scientific evidence supporting the use of herbal alternatives in managing depression. These phytochemicals offer potential benefits in addressing depressive symptoms through multiple mechanisms, including neuroprotection and neurogenesis. As research in this field continues to evolve, herbal treatments may provide a valuable adjunct or alternative to traditional therapies for individuals struggling with depression, particularly in cases of treatment resistance or intolerance to standard medications.
Contaminación sonora en los centros de diversión y el respeto al derecho de vivir tranquilo, Distrito de Morales
Authors: Silva Huamantumba Grethel , Silva Huamantumba Edman Junior , Chávez Quesquén Walther Fructuoso , Gutiérrez Vargas Consuelo del Pilar
Published: December 2023

Este estudio tiene como objetivo identificar la contaminación acústica en centros de recreación y cómo afecta el derecho a la vida de los residentes, a través de la correlación de variables asociadas al ruido molesto que interrumpe la tranquilidad en lugares públicos. El enfoque utilizado fue descriptivo y causal, utilizando métodos mixtos para evaluar la situación. Los datos se recopilaron a través de encuestas y entrevistas. Los resultados muestran que el 91,67% de los encuestados cree que la exposición al ruido de alta intensidad es la principal causa de la contaminación acústica, mientras que el 3,33% atribuye la causa a tráfico de automóviles y trimoviles, y el 1,67% a tráfico directo de motocicletas. En cuanto al daño en el sistema auditivo, el 83,33% de los encuestados indicó que la exposición al ruido de la calle puede provocar desgaste sensorial como la sordera, nervios, dolor de cabeza e irritabilidad, mientras que el 16,67% informó que el daño auditivo es solo dolor de cabeza.
Colexificación e imbricación en redes polisémicas: el caso del verbo mover en castellano
Authors: Silva Escudero Gisela , Castillo Silva Estela Vicenta , Atanasio Asencios Marilú Soledad
Published: December 2023

El verbo mover en castellano presenta un conjunto de sentidos que la tradición monosémica ha interpretado como un único significado que responde al contexto en el cual se usa; sin embargo, en el presente trabajo abordamos el fenómeno polisémico del verbo de movimiento en cuestión en términos de sus asociaciones con el lexema, esto es, con su capacidad para colexificar sentidos distintos. En tal sentido, determinamos los entrecruzamientos semánticos organizados en estructuras en las cuales es evidente la configuración de mapas semánticos; es decir, nos servimos de los presupuestos de la Lingüística Cognitiva (LC), según la cual los significados operan en relaciones que evidencian una clara motivación. Esta forma de evaluar los significados del verbo mover permite comprender cómo los hablantes de castellano son capaces de establecer distintas direcciones en las relaciones de significados o sentidos colexificados, de manera que es posible predecir y explicar los significados manifestados, los sentidos que pueden interpretarse y las diferencias dialectales. Detectamos que el verbo mover define un punto de referencia cognitivo motivado por la realidad material, pero puede extenderse a sentidos asociados con el concepto de proceso o cambio.
Teorías implícitas sobre la lectura en ingresantes universitarios con bajo rendimiento en comprensión de textos. Estudio de casos
Authors: Vilca-Rodríguez Mauricio , Torres-Orihuela Guido
Published: December 2023

Este estudio tuvo como objetivo general identificar las teorías implícitas acerca de la lectura en estudiantes que ingresan a la universidad con bajos niveles en la competencia «comprensión de textos». La investigación se desarrolló mediante el método de estudio de casos múltiple y se aplicó una entrevista semiestructurada a 15 ingresantes universitarios que obtuvieron resultados poco favorables en la prueba de lectura. Para tal fin, los datos se organizaron mediante un sistema de categorización que permitió analizar la correspondencia entre conceptualizaciones, objetivos de lectura y teorías implícitas. Se concluye que los estudiantes presentan concepciones de lectura propias de teorías implícitas reproductivas, interpretativas y literarias, lo que representa una mayor dependencia del lector respecto de lo que se dice en el texto.
Alfonso Zamorano Aguilar. La gramatización del español en el Perú del siglo XIX. Contribución a la historia de las ideas lingüísticas en América Latina
Authors: González Jiménez Juan Miguel
Published: December 2023

Resume
Faktor Yang Mempengaruhi Masyarakat Dalam Menggunakan Aplikasi Jak Lingko
Authors: Muhammad Wildan Pratama  , Toddy Aditya  , Adie Dwiyanto Nurlukman  , Yusuf Fadli
Published: December 2023

ABSTRACT

One of the cities in Indonesia with the highest population density is Jakarta. Congestion is considered a big problem that can be solved through an integrated transport system. This study aims to evaluate the impact of the implementation of Jak Lingko on the willingness of DKI Jakarta residents to use public transportation. The random sample used in this research methodology was quantitative and descriptive. Jak Lingko users in 2022 constitute the sample of this study, which includes a total of 295 respondents. The results showed a good and substantial relationship between convenience, benefits, and interest in using Jak Lingko transit in DKI Jakarta. The findings of this study can be a guide for the government in advancing the mobility of public transportation facilities and infrastructure in DKI Jakarta.

 

ABSTRAK

Salah satu kota di Indonesia dengan kepadatan penduduk tertinggi adalah Jakarta. Kemacetan dianggap sebagai masalah utama, yang dapat diselesaikan melalui sistem transportasi terintegrasi. Penelitian ini bertujuan untuk mengevaluasi dampak penerapan Jak Lingko terhadap kesediaan warga DKI Jakarta menggunakan angkutan umum. Sampel acak digunakan dalam metodologi penelitian ini adalah kuantitatif dan deskriptif. Pengguna Jak Lingko pada tahun 2022 merupakan sampel penelitian ini, yang mencakup total 295 responden. Hasil penelitian menunjukkan hubungan yang baik dan substansial antara kemudahan, manfaat, dan minat penggunaan Jak Lingko transit di DKI Jakarta. Temuan-temuan penelitian ini dapat menjadi panduan bagi pemerintah dalam memajukan mobilitas sarana dan prasarana transportasi publik di DKI Jakarta.
Akseptabilitas Penerapan Pembelajaran Berdiferensiasi pada Mata Kuliah MPK Bahasa Indonesia di Universitas Pendidikan Ganesha
Authors: Kadek Wirahyuni
Published: December 2023

Tujuan penelitian ini adalah ntuk (1) mengetahui implementasi pembelajaran berdiferensiasi pada mata kuliah MPK bahasa Indonesia di Universitas Pendidikan Ganesha yang terdiri atas konten, proses, produk, dan lingkungan belajar serta (2)  mengetahui penilaian berdiferensial yang terdiri atas penampilan, proses, dan progres pada mata kuliah MPK bahasa Indonesia Universitas Pendidikan Ganesha. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif analitis dengan pendekatan kualitatif. Implementasi pembelajaran berdiferensiasi pada mata kuliah MPK bahasa Indonesia di Universitas Pendidikan Ganesha yang terdiri atas konten, proses, produk, dan lingkungan belajar. Penilaian berdiferensial yang terdiri atas penampilan, proses, dan progres pada mata kuliah MPK bahasa Indonesia Universitas Pendidikan Ganesha. Instrumen penilaian penampilan yang dilakukan dalam pembelajaran berdiferensiasi ini terdiri atas kemampuan membedakan kata baku dan tidak baku, menganalisis kelas kata berdasarkan kategori, dan membuat media padanan kata. Instrumen penilaian proses yang dilakukan dalam pembelajaran berdiferensiasi ini terdiri atas kehadiran, keaktifan, disiplin, dan tanggung jawab. Instrumen penilaian progres yang dilakukan dalam pembelajaran berdiferensiasi ini terdiri atas tugas-tugas, UTS, dan UAS. Selain penilaian di atas, terdapat juga berbagai strategi penilaian formatif yang dilakukan dalam pembelajaran diferensiasi ini, di antaranya Sejemang, Pawang, Kertas Warna, Keranjang Evaluasi, dan Peta Acuan.
Ringed Spinytail-Iguana (Enyalioides annularis)
Authors: Arteaga Alejandro
Published: December 2023

This is the species account about the Ringed Spinytail-Iguana (Enyalioides annularis), a chapter in the Reptiles of Ecuador book. This account summarizes novel as well as historical information (recognition, natural history, distribution, conservation, etymology, and relevant literature) about the species and provides maps and images to facilitate identification of this reptile in the field.