bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of ALTA-1L (ALK in lung cancer trial of brigatinib in first-line), a randomized phase 3 trial of brigatinib (BRG) versus crizotinib (CRZ) in tyrosine kinase inhibitor (TKI)-naive patients (pts) with advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC).
Authors: Tiseo Marcello , Popat Sanjay , Gettinger Scott N. , Peters Solange , Haney Jeff , Kerstein David , Camidge D. Ross
Published: September 2018

TPS9098

Background: BRG is an investigational, next-generation ALK inhibitor with potent preclinical activity against rearranged ALK and CRZ-resistant mutants. In an ongoing phase 1/2 trial, BRG has shown promising intracranial and whole-body activity in ALK+ NSCLC pts with or without prior CRZ therapy ( Lancet Oncol. 2016;17:1683-96). In an ongoing pivotal randomized phase 2 trial (ALTA) evaluating 2 BRG regimens (90 mg qd and 180 mg qd with a 7-d lead-in at 90 mg), BRG has shown substantial objective response rates (ORRs) and robust progression-free survival (PFS) in pts with CRZ-resistant ALK+ NSCLC, particularly at 180 mg (with lead-in), and acceptable safety ( J Thorac Oncol. 2017;12:S612-3). Based on these results, the ALTA-1L trial was designed to assess the efficacy and safety of BRG vs CRZ in pts with advanced ALK+ NSCLC naive to TKI therapy (including ALK inhibitors). Methods: ALTA-1L (NCT02737501) is an open-label, multicenter, randomized phase 3 trial. Pts (≥18 y of age) are required to have locally advanced or metastatic ALK+ NSCLC, no prior TKI therapy, and ≤1 prior systemic anticancer regimen in the advanced setting. Approximately 270 pts will be stratified by presence of brain metastases at baseline and prior chemotherapy (yes/no) and randomized 1:1 to receive oral BRG (180 mg qd with a 7-d lead-in at 90 mg) or CRZ (250 mg bid). The primary endpoint is PFS per RECIST v1.1 assessed by a blinded independent review committee (BIRC); secondary endpoints include ORR, duration of response, overall survival, safety/tolerability, pt-reported outcomes, and intracranial ORR/PFS. The primary endpoint will be analyzed with the Kaplan-Meier method and a 2-sided stratified log-rank test after 198 events; 2 interim analyses are planned after approximately 50% and 75% of expected events. CRZ-treated pts may cross over to BRG (180 mg [with lead-in]) after BIRC-assessed disease progression. ALTA-1L was initiated in April 2016; 150 sites are planned in North America, Europe, and the Asia-Pacific region. 97 pts were enrolled as of February 6, 2017. Clinical trial information: NCT02737501.
B-F1RST: Assessment of novel blood-based biomarkers in patients with first-line advanced or metastatic NSCLC receiving atezolizumab monotherapy.
Authors: Kim Edward S. , Socinski Mark A. , Dakhil Shaker R. , Mackler Niklas J. , Ikhlaque Nadeem , Mekhail Tarek , Volterra Fabio , El Khoury Christian Antoine , Schiller Joan H. , Tsai Michaela L. , Hayek Fadi , Neidhart Jeffrey D. , Hunis Brian , Hu Sylvia , Paul Sarah M. , Shames David S. , Phan See-Chun , Yun Cindy , Velcheti Vamsidhar
Published: September 2018

TPS9103

Background: The anti–PD-L1 monoclonal antibody atezolizumab inhibits the interaction of PD-L1 with its receptors PD-1 and B7.1, thereby restoring T-cell immunity. In the Phase III OAK study, patients with previously treated advanced NSCLC had improved mOS in the atezolizumab arm (13.8 mo) vs the docetaxel arm (9.6 mo) (HR 0.73 [95%CI: 0.62, 0.87]; P= 0.0003), irrespective of PD-L1 expression or histology. A Phase III clinical trial of atezolizumab monotherapy for first-line, PD-L1–selected patients with NSCLC is underway; however, first-line atezolizumab monotherapy for NSCLC treatment in a biomarker-unselected population has not yet been investigated. Current assays to measure PD-L1 expression by IHC require tumor biopsies, which can be difficult to obtain in some patients. Novel blood-based biomarkers will be evaluated retrospectively in B-F1RST (Blood-First-Line Ready Screening Trial) in patients receiving atezolizumab monotherapy in first-line NSCLC. Methods: A Phase II, open-label, single-arm study, B-F1RST (NCT02848651), will evaluate the efficacy and safety of atezolizumab in PD-L1–unselected patients with first-line locally advanced or metastatic NSCLC. Eligibility criteria include stage IIIB-IVB NSCLC, ECOG PS 0-1, measurable disease per RECIST v1.1 and adequate hematologic and end-organ function. Exclusion criteria include the presence of EGFRmutations or ALKfusions, active CNS metastases and prior immunotherapy for NSCLC. Patients will receive atezolizumab 1200 mg IV q3w until disease progression or loss of clinical benefit. Prospective collection of blood samples is mandatory; collection of tissue biopsies is optional. The co-primary endpoints of the study are investigator-assessed ORR per RECIST v1.1 for the efficacy objective and PFS per RECIST v1.1 for evaluating blood-based predictive biomarkers for atezolizumab efficacy, including mutation status. Approximately 150 patients will be enrolled at 25 or more centers in the United States. Clinical trial information: NCT02848651.
CARSKIN: Pembrolizumab as first line therapy in patients with unresectable cutaneous squamous cell carcinoma (cSCC).
Authors: Maubec Eve , Helfen Sabine , Scheer-Senyarich Isabelle , Boubaya Marouane , Schischmanoff Olivier , Alloux Céline , Deschamps Lydia , Petrow Peter , Lopez Isabelle , Tibi Annick , Levy Vincent ,   GCC
Published: September 2018

TPS9596

Background: Treatment options are limited for patients (pts) with locally advanced or metastatic cSCCs. Cisplatin-based combinations have some efficacy but their toxicity often prohibits their use, particularly for the elderly. New therapeutic options are needed. Tumors divert the programmed death receptor 1 (PD-1) pathway suppressing immune control. Pembrolizumab (MK-3475) is a high-affinity humanized monoclonal anti-PD-1 antibody. It leads to dual PD-1 ligand (PD-L1 and PD-L2) blockade that may reactivate the immune surveillance and elicit anti-tumor response. It has antitumor activity in several tumors including head and neck SCCs. Moreover, an efficacy of pembrolizumab in cSCCs has been reported recently in a series of 6 cases. Methods: CARSKIN (ClinicalTrials.gov, NCT02883556) is a French multicenter, open-label, nonrandomized phase 2 trial, designed to evaluate the efficacy and safety of pembrolizumab in 39 pts with unresectable and/or metastatic cSCCs, naive of chemotherapy and of EGFR inhibitors. Pembrolizumab is administered (200 mg IV Q3W) for up to 24 months or until disease progression or unacceptable toxicity. Eligible pts must undergo a baseline biopsy of the tumor prior to treatment for PD-L1 evaluation. Response is to be assessed at baseline, wk 9, 15 and 24, and thereafter Q12W by central radiology review per RECIST 1.1 and per modified RECIST v1.1. The primary objective is response rate (RR) at wk 15 per RECIST 1.1. Secondary efficacy objectives are to assess whether patients with PD-L1+ tumors have a better RR than the whole sample at wk 15 and to assess in the whole sample and in PD-L1+ pts, disease control rate (DCR) at wk15, RR at wk 24, best RR, overall survival (OS), progression free survival (PFS), duration of response / control and time to disease progression. A Simon optimal two-stage design will be used. Four responders among 19 pts will be needed in the 1st step to continue the trial. Overall 9 responses will be needed to conclude the effectiveness. Kaplan-Meier statistics will assess PFS and OS. Adverse events (AEs) will be assessed throughout the study and for 30 d thereafter (6 m for serious AEs) and graded per NCI CTCAE v4.0. Clinical trial information: NCT02883556.
Case Report: Diffuse T wave inversions as initial electrocardiographic evidence in acute pulmonary embolism
Authors: Egini Ogechukwu , Dufresne Alix , Khalid Mazin , Egini Chinedu , Jaffe Eric
Published: September 2018

Acute pulmonary embolism (PE) is a life-threatening condition and is typically diagnosed by a combination of symptoms, clinical signs and imaging. Electrocardiogram may be helpful in diagnosis, and the most widely described pattern of occurrence is the so-called S1Q3T3 pattern. Here, we describe the case of an African-American male who presented with typical chest pain, diffuse T wave inversions with serial troponin elevation. There was initial concern for Wellen's syndrome but was finally diagnosed as acute PE. This case underscores the necessity of vigilance and a lower threshold for PE work up even in patients presenting as acute coronary syndrome.
THE PECULIARITIES OF FOREIGN LANGUAGE TRAINING OF TECHNICAL UNIVERSITY STUDENTS IN CONDITIONS OF COMPETENCE APPROACH
Authors: Bagateeva Angelina Olegovna , Ryseva Yuliya Viktorovna , Vasilyeva Aida Alegovna , Garaeva Rimma Salavatovna
Published: September 2018

В статье рассматриваются понятия «коммуникативная конкуренция» и «иноязычная коммуникативная компетентность». В основе исследования лежат такие методы, как наблюдение, анализ и моделирование. В статье представлена авторская интерпретация понятия иноязычной коммуникативной компетентности студентов с позиции компетентностного и системного подходов. Авторами представлен компонентный состав иноязычной коммуникативной компетенции с точки зрения различных исследователей, определены его структурные элементы. На основе проведенного анализа была построена модель модульной технологии иноязычной подготовки студентов технического вуза, дана характеристика ее структурных компонентов, а также описаны результаты ее реализации в процессе иноязычной подготовки студентов технического вуза. Использование модульной технологии в обучении студентов технических вузов иностранному языку позволяет получить высокий уровень иноязычной коммуникативной компетентности. Разработана модель модульной технологии иноязычной подготовки студентов технического вуза. Результаты исследования могут быть применены к иноязычной подготовке студентов не только технических, но и других вузов.
ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ КАРТ-ИНСТРУКЦИЙ В ОБЛАСТИ ШКОЛЬНОГО ХИМИЧЕСКОГО ОБРАЗОВАНИЯ
Authors: Farus Oksana Anatolevna , Abdiukova Elvira Fanilevna
Published: September 2018

В статье рассматривается проблема внедрения достижений современной химии в школьный курс. В рамках исследования решение данной проблемы предлагается за счет внедрения в школьное обучение практики использования карт-инструкций, которые содержат описание эксперимента по использованию тест-систем для определения качества объектов окружающей среды. Авторами представлен опыт по разработке и использованию карт-инструкций в рамках экологического практикума в школе города Оренбурга. Результаты опытно-экспериментальной работы показали, что применение разработанных карт-инструкций способствует повышению усвоения основных понятий и успешности обучающихся. В ходе исследования использовались методы сравнительного анализа, теоретических обобщений, наблюдение за ходом учебного процесса, опрос, анализ полноты выполняемых операций. Результаты исследования могут быть применены учителями химии, биологии для организации экологического практикума, а также в ходе написания исследовательских работ с обучающимися школ.
ПРОБЛЕМНОЕ ОБУЧЕНИЕ КАК МЕТОД РАЗВИТИЯ КРИТИЧЕСКОГО МЫШЛЕНИЯ СТУДЕНТОВ-БАКАЛАВРОВ ПРИ НАПИСАНИИ АРГУМЕНТИРОВАННОГО ЭССЕ
Authors: Bylkova Svetlana Viktorovna , Chubova Elena Pavlovna , Kolmakova Valentina Vasilievna
Published: September 2018

Цель. Статья посвящена проблеме подготовки студентов-бакалавров Донского государственного технического университета в условиях проблемного обучения. Предметом анализа выступает развитие критического мышления студентов в процессе написания аргументированного эссе. Авторы ставят своей целью выявить действенность письменной речи в форме аргументированного эссе как способа активации критического мышления студентов, определить критерии оценивания развития этого навыка.Результаты. Определены типы учебной активности, характеризующие развитие критического мышления студентов в процессе написания аргументированного эссе; предложена тематика данных эссе, нацеленная на выражение индивидуальной точки зрения на обсуждаемую ситуацию; установлен изоморфный характер между написанием аргументированного эссе и основными стадиями проблемного обучения; приведены базовые процедуры и результаты эксперимента, направленного на оценивание динамики развития критического мышления на этапах предварительного и финального тестирования.Область применения результатов. Результаты исследования могут найти последовательное применение в сфере подготовки студентов-бакалавров в технических и гуманитарных вузах.
PENGARUH LAJU PERTUMBUHAN INFLASI, HARGA MINYAK DUNIA DAN DOW JONES INDUSTRIAL AVERAGE TERHADAP INDEKS HARGA SAHAM GABUNGAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2007-2011
Authors: Pratama Rully Putra Surya , Kurniawati Indah
Published: September 2018

This research attempts to influence the inflation growth, the oil price dow jones industrial average to Composite Stock Price Index which is registred in indonesian stock exchange in the period of 2007-2011. The population in this research was the whole index in indonesian stock exchange (ISE). The sample was taken based on sampling purpodive. The data analysis technique used double linier regression. The dependent variable in this research was the growth of Composite Stock Price Index, while the independent variable was the inflation growth, the oil price and dow jones industrial average. The results of this research showed that the almost dependent variable used had effects for the growth of Composite Stock Price Index. The inflation rate growth variable did not have effects on Composite Stock Price Index growth, while the oil price rate variable and dow jones industrial average had effects on Composite Stock Price Index growth. Simultaneously, the independent variables examinedhere had effects on Composite Stock Price Index growth.
What should we do about crowding in emergency departments?
Authors: Higginson Ian , Boyle Adrian
Published: September 2018

Our emergency departments have never been under so much pressure. Crowding in these departments is both a cause and symptom of this pressure. Crowding kills patients and harms staff. It is the most important problem affecting emergency departments in the UK. The causes are described and include factors relating to input, throughput and output. Interventions aimed at these causes may confer benefit, but the most important problem remains unsolved. This is exit block caused by lack of beds, and flow through those beds, exacerbated by downgrading of capacity in unscheduled care in the evenings, weekends and during holiday periods.
Advanced clinical practitioners in emergency care: past, present and future
Authors: Crouch Robert , Brown Ruth
Published: September 2018

Developing a consistent and skilled workforce is critical to the sustainability of any clinical service. Nurses and paramedics have formed part of the emergency care workforce for many years and the extended role of these staff groups has supported patient care as the demand has risen and outstripped the capacity of the medical staff. In many hospitals and health-care systems, these extended roles have developed in response to local demand and case mix, resulting in inconsistent role descriptions and lack of transportable qualifications. Even for established roles such as emergency nurse practitioners, there is no UK-wide defined scope of practice or curriculum to support the role.

In 2014 a joint working group of the Royal College of Emergency Medicine and Health Education England agreed a programme of work to support a sustainable emergency care workforce. One stream of that work focused on developing non-medical roles within emergency care and in particular the role of the advanced clinical practitioner in emergency medicine.

Advanced practice has developed in the UK in many specialties and the new advanced practice framework from Health Education England (2017) allows a cross-discipline understanding of the principles and key aspects of advanced practice. However, this framework is naturally generic and does not focus on what a practitioner is capable of within a specific clinical area, but more on the core capabilities. This article outlines the development of a UK-wide curriculum and credentialing process for emergency care advanced clinical practitioners and reports on progress to date.
MRI and sonography in Legg-Calvé-Perthes disease: Clinical relevance of containment and influence on treatment
Authors: Jandl N. M. , Schmidt T. , Schulz M. , Rüther W. , Stuecker M. H. F.
Published: September 2018

Purpose

The containment orientated treatment of Legg-Calvé-Perthes disease (LCPD) affected hip joints is broadly accepted in the literature. The prerequisite is early recognition of loss of containment. An often-used quantitative MRI containment parameter is the cartilaginous acetabulum-head-index (CAHI). Based on ultrasound (US), we analyzed the newly created ‘femoral head extrusion angle’ (HA) as a containment parameter in comparison with the CAHI in severe LCPD.

Methods

In a prospective study with 40 children (mean age 5.8 years sd 2.3) with unilateral LCPD classified as Catterall group III/IV, we measured the CAHI versus HA to assess the containment of the femoral head. HA in US was determined by the tangent from the bony acetabular rim to the cartilaginous cranio-lateral femoral head.

Results

The HA was significantly higher in LCPD-affected hip joints (25° sd 7°) than in healthy ones (13° sd 5°; p < 0.001). Correlation analysis of all hip joints revealed a significant correlation between HA and CAHI (r = −0.69; p < 0.001). Hip joints with a low CAHI indicating loss of containment showed a higher HA in sonography.

Conclusion

The results of our study suggest that the HA in US is a reliable containment parameter in severe LCPD with a HA > 22° defining a pathologic value. In comparison with the CAHI, HA measurement in ultrasound is easier than the assessment of various parameters to calculate an index. Frequent sonographical follow-up assessment in critical joints is an alternative if MRI is not available, helping to detect an impending loss of containment early enough.

Level of Evidence

Level II
Rehabilitating North Waziristan
Authors: Naveed Yousaf  , Muhammad Bashir Khan  , Shahzad Hussain
Published: September 2018

This paper is about one of the world's most strategic area, inhabited by a large tribal population. After the involvement and destruction of this area and its people in the Great Game and the Cold War, it is once again confronted with the War on Terror. Being important in the global politics and considered as a threat to national and international security, the national and international leadership are making plans and programs to eradicate this area of extremism. It is accepted that force alone cannot eradicate the menace of extremism from this area, but the military effort must be supported by robust development that can bring social and economic changes in the lives of the people. For this purpose, huge funds have started flowing into the area after the incident of 9/11. However, despite financial and human resources pooled for the purpose, no fruitful results have yet been achieved. Reasons being that the development activities of all the developing partners including the government of Pakistan are not coordinated, planned and according to the ground realities shaped by war and insurgency. To mainstream the people and the area a robust development strategy keeping in view the ground situation in mind is required.
Optical pre-screening for laryngeal cancer using reflectance spectroscopy of the buccal mucosa
Authors: Bugter Oisín , Hardillo Jose A. , Baatenburg de Jong Robert J. , Amelink Arjen , Robinson Dominic J.
Published: September 2018

A new approach in early cancer detection focuses on detecting field cancerization (FC) instead of the tumor itself. The aim of the current study is to investigate whether reflectance spectroscopy can detect FC in the buccal mucosa of patients with laryngeal cancer. The optical properties of the buccal mucosa of patients were measured with multidiameter single-fiber reflectance spectroscopy. The blood oxygen saturation and blood volume fraction were significantly lower in the buccal mucosa of laryngeal cancer patients than in non-oncologic controls. The data of these two parameters were combined to form a single ‘biomarker α’, which optimally discriminates these two groups. Alpha was lower in the laryngeal cancer group (0.28) than the control group (0.30, p = 0.007). Alpha could identify oncologic patients with a sensitivity of 78% and a specificity of 74%. These results might be the first step toward optical pre-screening for laryngeal cancer.
A EXTENSÃO UNIVERSITÁRIA NO FORTALECIMENTO DA REDE DE CUIDADOS À PESSOA COM DEFICIÊNCIA
Authors: Stüpp Ana Carolina Steiner , Durante Adrielly Marconato , De Aquino Ana Paula Marcelino , Semioni Camila Carolain da Cruz , E Silva Graciele Pêssoa , Perão Leonardo , Fialho Indiara de Mesquita , Pagnossim Débora Frizzo , Viana Simone Beatriz Pedrozo
Published: September 2018

O presente estudo tem por objetivo relatar a experiência de um projeto de extensão universitária que busca fortalecer a rede de cuidados à pessoa com deficiência auditiva, física e intelectual, a partir de ações de educação permanente. Este estudo é documental, elaborado a partir da análise qualitativa de conteúdo dos registros das atividades e dos relatórios produzidos pelo projeto de extensão Grupo de Apoio à Rede de Cuidados à Pessoa com Deficiência, nos quais constam as falas dos participantes das capacitações. A experiência vem ampliando a integração ensino-serviço, assim como o vínculo entre os diferentes níveis de atenção à saúde, apoiada na construção de redes de apoio à pessoa com deficiência. Acredita-se que a educação permanente é o caminho para a consolidação e a qualificação do processo de cuidado.
REVISTA CAROS AMIGOS E MANIFESTAÇÕES DE JUNHO 2013: UMA ANÁLISE ÉTICO-POLÍTICA
Authors: Caetano Leide Dayana , Lima Rita de Cássia Gabrielli Souza
Published: September 2018

Este artigo apresenta parte dos resultados de pesquisa de mestrado sobre as reivindicações populares expressas nas manifestações de junho de 2013. Pesquisa documental, realizada na versão on-line da Revista Caros Amigos, com recorte temporal entre 01/06/2016 e 31/10/2016. A análise ético-política das notícias foi conduzida por meio da categoria "De Saúde como Direito Social à Democracia como Direito à Saúde". A partir das relações com os dados, foi possível concluir que as manifestações geraram desdobramentos em matéria de direitos sociais. O Plano Nacional de Educação foi instituído com metas para até 2024. O Programa Mais Médicos foi criado, garantindo atenção médica na atenção básica do SUS de Brasis desassistidos. A produção e a difusão de saberes e reconhecimentos populares produziram uma tecnologia social, pois viabilizaram os anseios de uma população que historicamente luta por seus direitos e busca a cada dia, em meio à opressão e ao sofrimento, fazer com que suas vozes sejam ouvidas e seus anseios atendidos nesta democracia representativa sem representatividade. Ainda assim, fica a compreensão de que o Brasil requer um choque de cidadania, para que possa defender um projeto justo de sociedade.
Aspects of ecological anatomy of Traganum nudatum Del. (Amaranthaceae) from the Northeast of the Algerian Sahara
Authors: Kherraze Mohamed Elhafed , Belhamra Mohamed , Grigore Marius-Nicuşor
Published: September 2018

This study focuses on the anatomical strategies developed by the Traganum nudatum Del., prevalent in the Algerian Sahara, particularly in the region of Oued Righ, which allows to this species to survive in a harsh environment (aridity and salinity). The anatomical structure of this species was studied using fresh materials (roots, stems and leaves). These materials have been collected from several individuals in different saline habitats. Some interesting features such as successive cambia phenomenon, calcium oxalate crystals, Kranz anatomy (salsoloid subtype), succulence, low stomata density, low stomata index, the presence of the papillae, paracytic stomata and other structures have been noticed. We can conclude that the ecological significance of evidenced adaptations by T. nudatum is supported in this article by the analysis of adaptations of other species belonging either to the Amaranthaceae or to other botanical families; and that this adaptation has no link with botanical families. In these species, the key adaptation is the ability to maintain growth processes and water saving under difficult living conditions (high summer temperatures or salty soils), regardless of the evolutionary level of the taxon.
Assessment of Ventilated Athletic Uniforms for Improved Thermal Comfort
Authors: McQuerry Meredith , Hogans Kristian
Published: September 2018

Due to disproportionate rates of American football players experiencing heat illness injuries and fatalities, there is a need to focus on the thermal comfort of athletes. Intolerance of internal metabolic heat production is a result of insufficient air flow in athletic uniforms. The application of clothing ventilation may significantly improve the thermal comfort of the athlete. Therefore, the purpose of this research was to investigate the thermal comfort of ventilated football uniforms based on ventilation type (traditional mesh versus laser micro-perforated). Ventilated football uniforms were evaluated for air permeability and subjective thermal comfort. Heart rate, perceived exertion, perceived comfort, and thermal sensation were collected during a human wear trial. Findings indicate differences in air permeability and thermal comfort perceptions between the ventilated uniforms.
Performance Evaluation of Selected Coagulants for the Removal and Reuse of Textile Wastewater Containing C.I. Reactive Black 5
Authors: Firdous Nabeela , Shaikh Irfan Ahmed , Islam Sana , Sadef Yumna
Published: September 2018

This study was carried out to investigate the comparative effectiveness of ferrous sulfate (FeSO4) and magnesium chloride (MgCl2) in removing color from synthetic C.I. Reactive Black 5 dye wastewater. After chemical coagulation, treated wastewater was reused in the wash-off process. Using 400 ppm of MgCl2, a color removal efficacy of 97% was achieved at pH 12 for synthetic Reactive Black 5 dye wastewater. Coagulant FeSO4 yielded 85% color removal efficiency under the same conditions. The fabric washed with coagulant-treated wastewater had a total color difference (Δ Ecmc) value of <1.0, which is commercially acceptable. The colorfastness of the fabrics washed with coagulant-treated wastewater was comparable to those washed off with fresh water.
The Current State of Tax Administration in Ukraine: an Analytical Review of Terminology
Authors: KOLOMIIETS Pavlo V.
Published: September 2018

Abstract:
The article includes the study of contemporary legal problems of regulation of the collection of taxes and fees and submit proposals for their improvement.
Analysis of current tax legislation Ukraine, departmental regulations and practices for their implementation, theoretical understanding of scientific works, publications and recent research shows that today urgently needs further reformatting the Tax Code of Ukraine. Recently, discussions around the Tax Code of Ukraine tend to increase. Particularly sharp criticism is about the quality of writing legal text of the Code, its shape and structure.
The current topic of contemporary tax debates in Ukraine is the imperfection of the current norms of the Tax Code. The generally acknowledged problem in the field of tax legislation is recognized by the language and technical quality of tax law-making.
Consequently, the study of legal problems in the regulation of relations in the field of collecting taxes and fees shows that one of the principles on which the tax legislation of Ukraine should be based on the principle of uniqueness and stability of the meanings of concepts. In accordance with them, the legal rules of the tax legislation should be formulated clearly. Legal terms should be used in the texts of tax legislation in a logical and consistent manner. That is, the formation of tax terms, their consolidation in modern tax legislation should take place on their own tax base.
Imperative provisions of the Tax Code of Ukraine, which are based on positive obligations must provide clarity, intelligibility of tax regulations. Another problem, in our opinion, is the question of efficient use in existing Ukrainian tax legislation concepts of ‘special tax regime’, ‘generic tax regime’, ‘tax regime’, ‘special regime’.
Prospects for Renovation of Prefabricated Buildings as a Source of Redevelopment without the Demolition of Existing Buildings
Authors: KOZHEVNIKOV Dmitry
Published: September 2018

The paper defines the conditions, methods and forms of the renovation of the buildings in cases when they do not require a significant investment and new construction at forming of the structure of construction system. It is shown that the use of buildings for renovation without their demolition and repeated construction, has been tested to a large extent not only in the territory of the countries where commercial housing construction has been largely used in a long exposure, but also in the countries of former ‘Socialist bloc’. Countries, where panel housing construction accounts for more than 30% of the entire house fund and gradually leads to its destruction due the end of life, were taken as the examples. The novelty of the paper is the position offering not only the housing renovation measures, but also the design solutions that may be used in the development of the overall concept of house-building strategy. The article has its applied value in the structure of development of integral video-ecological bases for the design of mass buildings of housing construction. The further direction of research is determining of the possible development of panel housing construction in the territory of the state, due to the extensive experience in the construction of similar buildings of the housing stock.
Standard for the Development of Competition as a Special Model of Antitrust Policy at the Regional Level
Authors: RODIONOVA Daria Nikolaevna , BAZAROV Alexey Tsyrenovich , MUNKUEVA Irina Sergeevna , TSYRENOV Dashi Dashanimaevich , TULOKHONOV Oleg Sergeevich
Published: September 2018

Abstract:

The aim of this paper is to study the nature and sense of the antitrust policy of the state from the perspective of introduction of a special policy document –the Standard for the Development of Competition in the Administrative Regions of the Russian Federation (SDCAR). The article covers the specifics and the importance of governing competitive relations in the market business environment; the data on the Republic of Buryatia are considered as working material. The methodological basis of the study is the systematic approach, a comprehensive study of the competitive relationships governance practices. The authors analyzed measures to develop and strengthen competition parameters in the region, carried out in accordance with the provisions of the SDCAR. The article describes the algorithm for implementation of activities, adapting the concept on improvement of the quality of assessment of the antitrust regulation efficiency in connection with business entities. The authors identified a set of factors that influence the formation of the approaches to implementation of competition policy in Buryatia. The conclusions and recommendations offered herein can be used by federal and regional authorities in the development and adoption of laws and other regulations on the formation of a favorable competitive environment; by municipal authorities – in the analysis and monitoring of the status and development of the local competitive environment in the area.
State of Scientific Research of Knowledge Management in the Republic of Kazakhstan
Authors: USKELENOVA Assel T. , SHADIYEV Kairatbek Kh. , KULAZHANOV Yernur
Published: September 2018

Substantiated the necessity of developing the theoretical scientific basis for the development of the knowledge management system in the Republic of Kazakhstan (RK). The research directions of Kazakhstani scientists in the field of the knowledge economics are analyzed and theoretically generalized, and the limited nature of objects of research in the field of problems is argued. The main directions of the scientific search in the framework of knowledge management are revealed. This approach contributes to the objectivism and actualization of scientific research and promotes the theoretical and methodological basis formation for the development of the knowledge management system in the Republic of Kazakhstan.
Current Trends in the Financial Market Development
Authors: ZATSARINNYI Еlena I. , MALYKH Natalya I. , SEVERINA Yulia N. , GENDON Angelica L. , MINNULLINA Anna Yu. , MALYSHENKO Kostyantyn A.
Published: September 2018

The paper shows that the modern tendencies of financial market based on the possibility of stratification and infrastructural development of the economy as a whole. The authors found that special attention should be given to development of infrastructural support from the state, and the formation of technological trends in the structure of public consumption.

The article indicates that financial market conditions are set on the basis of the calculation of both financial and investment risks, which facilitate the effective use of capital. The authors note a trend in which the rapid processes of globalization have transformed the infrastructure of the financial market on one of the dominant redistribution of capital not only within national economies but also on a global scale. It is established that financial market participants form a functional component of infrastructure capacity because of accumulation of financial resources has a functional purpose. The functional component of the infrastructural capacity of the financial market is in the process of transformation. This is a withdrawal from the market of a number of financial intermediaries, reduced the volume of assets of financial institutions, reduced demand for their services, which in the long run it will escalate the competition for the consumer between them. This will stimulate the emergence of new financial services and will contribute to the infrastructural capacity of the financial market.
Gesamtwirtschaftliche Kosteneinsparpotenziale durch das automatisierte Fahren
Authors: Roos Michael , Siegmann Marvin
Published: September 2018

In dieser Studie wird abgeschätzt, welche gesamtwirtschaftlichen Kosteneinsparungen das automatisierte Fahren für Deutschland bringen könnte. Durch automatisiertes Fahren können Unfälle und Staus vermieden werden. Zudem ist zu erwarten, dass der Parkverkehr in den Innenstädten zurückgeht. Insgesamt ergibt unsere Abschätzung ein Einsparpotenzial von 24,9 Mrd. Euro pro Jahr bei einer mittleren Marktdurchdringung. Dies entspricht etwa 0,8 % des deutschen Bruttoinlandsprodukts im Jahr 2016. Gemessen am Wirtschaftswachstum von 1,9 % im Jahr 2016 ist dies erheblich. Von besonderem Interesse ist auch die Kostenersparnis je Pkw, da somit private Kosten der Anschaffung mit sozialen Erträgen verglichen werden können. Im mittleren Szenario erhalten wir eine Kostenersparnis von 1.351 Euro pro Jahr und Pkw.
Automatisiertes Fahren als Herausforderung für Städte und Regionen
Authors: Perret Fabienne , Fischer Remo , Frantz Holger
Published: September 2018

Das automatisierte Fahren hat das Potenzial, unsere alltägliche Mobilität grundlegend zu verändern. Auf Basis eines denkbaren Entwicklungspfades werden die heute absehbaren Auswirkungen, insbesondere aus Sicht der Städte und Regionen, hergeleitet. Dabei stehen Chancen wie Effizienzgewinne, neue Mobilitätsangebote und eine Erhöhung der Verkehrssicherheit den Herausforderungen wie potenzielle Verkehrszunahmen, Anpassungen der Regulierungen oder der Aufbau einer Dateninfrastruktur gegenüber. Ob das automatisierte Fahren gesamthaft einen Nutzen bringen wird, hängt deutlich von der Einflussnahme der Politik ab.
Can human and artificial agents share an autonomy, categorical imperative-based ethics and “moral” selfhood?
Authors: Nowak Ewa
Published: September 2018

AI designers endeavour to improve ‘autonomy’ in artificial intelligent devices, as recent developments show. This chapter firstly argues against attributing metaphysical attitudes to AI and, simultaneously, in favor of improving autonomous AI which has been enabled to respect autonomy in human agents. This seems to be the only responsible way of making further advances in the field of autonomous social AI. Let us examine what is meant by claims such as designing our artificial alter egos and sharing moral selves with artificial humanoid devices as well as providing autonomous AI with an ethical framework modelled upon the core aspects of moral selfhood, e.g., making decisions which are based on autonomous law-giving, in Kantian terms.
The Choosing Wisely initiative and laboratory test stewardship
Authors: Baird Geoffrey S.
Published: September 2018

The United States Choosing Wisely initiative was started in 2012 by the American Board of Internal Medicine Foundation and focused on reducing medical resource overutilization. Since its inception in the US, similar efforts have arisen in at least a dozen countries. Strongly patient-focused, and in fact started in collaboration with the consumer magazine Consumer Reports, the effort has resulted in a collection of greater than 500 recommendations from over 80 US professional societies intended to inform both patients and doctors about medical practices whose necessity should be questioned or discussed. Targets of recommendations include practices that lack a basis in scientific evidence, practices that may be duplicative of other care already received, practices that may be harmful and practices that are simply unnecessary. While critiques have been levied against the Choosing Wisely initiative over its intent, methods and efficacy, it is clear that many of its recommendations have been adopted by large medical practices, and several positive outcomes, i.e. reductions in perceived waste, have been reported in relation to many of the recommendations, including those specifically targeting laboratory tests. The future success of Choosing Wisely will likely hinge on whether or not significantly positive and durable outcomes can be demonstrated, especially at a time where there is increasing pressure to drive down costs in medical care while concomitantly increasing quality.
First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study
Authors: Correa Paula J. , Venegas Pia , Palmeiro Yasna , Albers Daniela , Rice Gregory , Roa Jaime , Cortez Jorge , Monckeberg Max , Schepeler Manuel , Osorio Eduardo , Illanes Sebastian E.
Published: September 2018

Objectives

To evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).

Methods

The study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).

Results

The GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.

Conclusion

Women who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.
The Cognitive Aspect of Christian Faith and Non-doxastic Propositional Attitudes
Authors: Eklund Dan-Johan Sebastian
Published: September 2018

In the recent discussion, several authors have argued for the claim that propositional faith need not be doxastic, but also can be “non-doxastic”. Notable proponents of this view are William Alston, Robert Audi, Daniel Howard-Snyder, and J. L. Schellenberg. In this paper, I focus on Christian faith and consider whether its cognitive aspect can be understood solely in terms of Alston’s and others’ non-doxastic accounts. I argue for a negative answer. In my view, the cognitive aspect of Christian faith calls for, as a minimum, “a sub-doxastic attitude”. As there is no shared terminology on this topic, a proportion of this paper deals with conceptual clarifications.
Design Discourse: A Way Forward for Theistic Evolutionism?
Authors: Kojonen Erkki Vesa Rope
Published: September 2018

It is usually supposed that biological design arguments (where biological complex order is seen as evidence of a Creator) are made obsolete by Darwinian evolutionary theory. However, philosopher Alvin Plantinga and others have defended the continued possibility of a rational “design discourse”, in which biological order is taken as a sign of God’s purposeful action. In this article, I consider two objections to design discourse: (1) a theological objection to biological design based on the problem of natural evil, and (2) the evolutionary objection, according to which evolutionary theory removes the justification for any biological design perception. Whereas Plantinga’s own response utilizes the arguments of the Intelligent Design movement, I argue in favor of utilizing “design discourse” as part of a theistic evolutionist view.
A novel database of bio-effects from non-ionizing radiation
Authors: Leach Victor , Weller Steven , Redmayne Mary
Published: September 2018

A significant amount of electromagnetic field/electromagnetic radiation (EMF/EMR) research is available that examines biological and disease associated endpoints. The quantity, variety and changing parameters in the available research can be challenging when undertaking a literature review, meta-analysis, preparing a study design, building reference lists or comparing findings between relevant scientific papers. The Oceania Radiofrequency Scientific Advisory Association (ORSAA) has created a comprehensive, non-biased, multi-categorized, searchable database of papers on non-ionizing EMF/EMR to help address these challenges. It is regularly added to, freely accessible online and designed to allow data to be easily retrieved, sorted and analyzed. This paper demonstrates the content and search flexibility of the ORSAA database. Demonstration searches are presented by Effect/No Effect; frequency-band/s; in vitro; in vivo; biological effects; study type; and funding source. As of the 15th September 2017, the clear majority of 2653 papers captured in the database examine outcomes in the 300 MHz–3 GHz range. There are 3 times more biological “Effect” than “No Effect” papers; nearly a third of papers provide no funding statement; industry-funded studies more often than not find “No Effect”, while institutional funding commonly reveal “Effects”. Country of origin where the study is conducted/funded also appears to have a dramatic influence on the likely result outcome.
Progress in research on the role of Omi/HtrA2 in neurological diseases
Authors: Su Xiao Juan , Huang Lingyi , Qu Yi , Mu Dezhi
Published: September 2018

Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondrial matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the biological characteristics of Omi/HtrA2 and its role in neurological diseases, which will provide new hints in developing Omi/HtrA2 as a therapeutic target for neurological diseases.
Cyclosporine-A induces apoptosis in human prostate cancer cells PC3 and DU145 via downregulation of COX-2 and upregulation of TGFβ
Authors: Cevik Ozge , Turut Fatma Aysun , Acidereli Hilal , Yildirim Sahin
Published: September 2018

Background

Potential targets for prostate cancer therapy are urgently needed for curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. However, the molecular effects of CsA is not fully understood in prostate cancer. In this research, we sought to determine role and mechanism of CsA in prostate cancer.

Materials and methods

PC3 and DU145 cells were treated with CsA time (12, 24, 48 h) and dose dependent (2.5, 10, 25 μM) and cell survival, migration, colony formation, expression of apoptosis related proteins/genes using MTT assay, scratch assay, Western blotting/qPCR. At the same time, cells treated with CsA to test on the effects of COX-2 promoter activity using luciferase reporter plasmid. Lastly, functional role in the CsA treatment prostate cancer cells were interrogated for relationship of TGFβ, Akt, caspases and COX-2.

Results

These study findings provided direct evidences that the CsA induced apoptosis and downregulated migration.

Conclusions

CsA downregulated Akt as well as COX-2 and upregulated TGFβ, resulting in the suppression of cell migration which was augmented a potential therapeutic of CsA in prostate cancer cells.
Acercándonos al dibujo a través de un proyecto audiovisual / Approaching the drawing through an audiovisual project
Authors: Horno López Antonio , Garrido Parrilla Joaquín David
Published: September 2018

Es bien conocido la apuesta de la educación por la innovación y unas metodologías de aprendizaje que vayan más allá de los recursos tradicionales utilizados dentro de las aulas. El uso de nuevas tecnologías, la incorporación de sonido, imagen y movimiento, crea un nuevo recurso metodológico que permite la integración y participación del alumnado en las actividades de clase.  En este trabajo se analizan las ventajas e inconvenientes encontrados durante la ejecución de un proyecto audiovisual en la asignatura “Las Artes Plásticas y Cultura Audiovisual en Educación Primaria” en la Universidad de Jaén, en el que a través de la incorporación de las herramientas digitales más actuales y la disposición de los alumnos  en grupos de trabajo se ha logrado fomentar el trabajo cooperativo y el interés de unos estudiantes saturados, en muchas ocasiones, por los trabajos teóricos y las clases magistrales.