bluuebunny/crossref_metadata_2025 huggingface dataset:
Review on Plant-Based Management in Combating Antimicrobial Resistance - Mechanistic Perspective
Authors: Arip Masita , Selvaraja Malarvili , R Mogana , Tan Lee Fang , Leong Mun Yee , Tan Puay Luan , Yap Vi Lien , Chinnapan Sasikala , Tat Ng Chin , Abdullah Maha , K Dharmendra , Jubair Najwan
Published: September 2022

Antimicrobial resistance (AMR) occurs when microbes no longer respond to any pharmacological agents, rendering the conventional antimicrobial agents ineffective. AMR has been classified as one of the top 10 life-threatening global health problems needed multilevel attention and global cooperation to attain the Sustainable Development Goals (SDGs) according to the World Health Organization (WHO), making the discovery of a new and effective antimicrobial agent a priority. The recommended treatments for drug-resistant microbes are available but limited. Furthermore, the transformation of microbes over time increases the risk of developing drug resistance. Hence, plant metabolites such as terpenes, phenolic compounds and alkaloids are widely studied due to their antibacterial, antiviral, antifungal and antiparasitic effects. Plant-derived antimicrobials are preferred due to their desirable efficacy and safety profile. Plant metabolites work by targeting microbial cell membranes, interfering with the synthesis of microbial DNA/RNA/enzymes and disrupting quorum sensing and efflux pump expression. They also work synergistically with conventional antibiotics to enhance antimicrobial effects. Accordingly, this review aims to identify currently available pharmacological therapies against microbes and AMR, as well as to discuss the importance of plant and secondary metabolites as a possible solution for AMR together with their mechanisms of action. All the information was obtained from government databases, WHO websites, PubMed, Springer, Google Scholar and Science Direct. Based on the information obtained, AMR is regarded as a significant warning to global healthcare. Plant derivatives such as secondary metabolites may be considered as potential therapeutic targets to mitigate the non-ending AMR.
Evidence basis for using dexmedetomidine to enhance the quality of paravertebral block: A systematic review and meta-analysis of randomized controlled trials
Authors: Tang Rong , Liu Yu-Qian , Zhong Hai-Lian , Wu Fang , Gao Shi-Xiong , Liu Wei , Lu Wen-Sheng , Wang Ying-Bin
Published: September 2022

Background: Dexmedetomidine is considered an adjunct to local anaesthesia (LA) to prolong peripheral nerve block time. However, the results from a previous meta-analysis were not sufficient to support its use in paravertebral block (PVB). Therefore, we performed an updated meta-analysis to evaluate the efficacy of dexmedetomidine combined with LA in PVB.

Methods: We performed an electronic database search from the date of establishment to April 2022. Randomized controlled trials (RCTs) investigating the combination of dexmedetomidine and LA compared with LA alone for PVB in adult patients were included. Postoperative pain scores, analgesic consumption, and adverse reactions were analyzed.

Results: We identified 12 trials (701 patients) and found that the application of dexmedetomidine as a PVB adjunct reduced the postoperative pain severity of patients 12 and 24 h after surgery compared to a control group. Expressed as mean difference (MD) (95% CI), the results were −1.03 (−1.18, −0.88) (p < 0.00001, I2 = 79%) for 12 h and −1.08 (−1.24, −0.92) (p < 0.00001, I2 = 72%) for 24 h. Dexmedetomidine prolonged the duration of analgesia by at least 173.27 min (115.61, 230.93) (p < 0.00001, I2 = 81%) and reduced postoperative oral morphine consumption by 18.01 mg (−22.10, 13.92) (p < 0.00001, I2 = 19%). We also found no statistically significant differences in hemodynamic complications between the two groups. According to the GRADE system, we found that the level of evidence for postoperative pain scores at 12 and 24 h was rated as moderate.

Conclusion: Our study shows that dexmedetomidine as an adjunct to LA improves the postoperative pain severity of patients after surgery and prolongs the duration of analgesia in PVB without increasing the incidence of adverse effects.
Potential therapeutic strategies for quercetin targeting critical pathological mechanisms associated with colon adenocarcinoma and COVID-19
Authors: Li Xiushen , Liang Weizheng , Yu Chengwei , Meng Qingxue , Zhang Weiwen , Wu Xueliang , Xue Jun , Deng Shoulong , Wang Hao
Published: September 2022

Patients with colon adenocarcinoma (COAD) are at a higher probability of infection with COVID-19 than healthy individuals. However, there is no globally accepted treatment protocol for patients with COAD/COVID-19. Quercetin has been found to have significant antitumor, antiviral and anti-inflammatory effects in several studies. Therefore, this study sought to evaluate the potential of quercetin as the agent for COAD/COVID-19 and to explore its mechanisms. We used bioinformatics algorithms to obtain COAD/COVID-19-related genes (CCRG) from COAD-related transcriptome data and COVID-related transcriptome sequencing data, and used these genes to construct a COAD prognostic model. We intersected the CCRG with the therapeutic target genes of quercetin and obtained a total of 105 genes (potential target genes of quercetin for the treatment of COAD/COVID-19). By constructing a protein-protein interaction (PPI) network, we ascertained FOS, NFKB1, NFKB1A, JUNB, and JUN as possible core target genes of quercetin for the treatment of COAD/COVID-19. Bioinformatic analysis of these 105 genes revealed that the mechanisms for quercetin the treatment of COAD/COVID-19 may be associated with oxidative stress, apoptosis, anti-inflammatory, immune, anti-viral and multiple pathways containing IL-17, TNF, HIF-1. In this study, we constructed a prognostic model of COAD/COVID19 patients by using CCRG and elucidated for the first time the potential target genes and molecular mechanisms of quercetin for the treatment of COAD/COVID-19, which may benefit the clinical treatment of COAD/COVID-19 patients. However, no clinical trials have yet been conducted to further validate the findings, but this will be the future direction of our research.
Daphnetin: A bioactive natural coumarin with diverse therapeutic potentials
Authors: Javed Maira , Saleem Ammara , Xaveria Anne , Akhtar Muhammad Furqan
Published: September 2022

Daphnetin (DAP), a coumarin derivative extracted from Daphne species, is biologically active phytochemical with copious bioactivities including anti-inflammatory, anti-oxidant, neuroprotective, analgesic, anti-pyretic, anti-malarial, anti-bacterial, anti-arthritic, neuroprotective, hepatoprotective, nephroprotective, and anti-cancer activities. A wide range of studies have been conducted exploring the significance and therapeutic potential of DAP. This study reviewed various databases such as NCBI, PubMed, Web of Science, Scopus and Google Scholar for published research articles regarding the sources, synthesis, and various bioactivities of DAP using different key words, including but not limited to “pharmacological activities,” “sources,” “neuroprotective effect,” “synthesis,” “cancer,” “anti-inflammatory effect” of “daphnetin.” Furthermore, this review encompasses both in-vivo and in-vitro studies on DAP for treating various diseases. A comprehensive review of the literature revealed that the DAP had a promising pharmacological and safety profile, and could be employed as a pharmaceutical moiety to treat a variety of illnesses including microbial infections, cancer, arthritis, hepatic damage, inflammation and neurological anomalies. The current review intends to provide an in-depth focus on all pharmacological activities and therapeutic approaches for the pharmaceutical and biomedical researchers.
Effects of high-intensity interval training in combination with detraining on mental health in women with polycystic ovary syndrome: A randomized controlled trial
Authors: Santos Isis K. , Pichini Gabriel S. , Daniel d. Ferreira Carlindo , Dantas Pedro B. , Browne Rodrigo A. V. , de Queiros Victor , Soares Gustavo M. , Gonçalves Ana K. , Cabral Breno G. , Maranhão Tecia Maria O. , Dantas Paulo Moreira S.
Published: September 2022

This study aimed to investigate the effects of high-intensity interval training (HIIT) and detraining on the quality of life and mental health of 23 women with polycystic ovary syndrome (PCOS). Participants were randomly assigned to the HIIT group (n = 12) [26.0 ± 3.92] and the control group (n = 11) [26.6 ± 4.68]. HIIT sessions comprised 40–60 min, 3 days a week for 12 weeks, followed by detraining for 30 days. We assessed the quality of life using the Short Form Health Survey (SF-36) and mental health by the Depression, Anxiety, and Stress Scale (DASS-21), and we compared group changes on these variables at three time points: 1) at baseline, 2) after 12 weeks of HIIT (or no training), and 3) after 30 days of detraining (or no training). The participants were classified as overweight and had a high percentage of body fat (41.5%) and irregular menstrual cycles (amenorrhea) (66.7%). Throughout training, participants in the HIIT group reported improvements in domains of the quality of life: functional capacity (M = 80.4 ± 3.4 vs. M = 87.0 ± 3.1), physical role functioning (M = 72.5 ± 9.4 vs. M = 81.8 ± 9.7), and general health perception (M = 48.6 ± 4.6 vs. M = 69.0 ± 5.8). Regarding anxiety symptoms (M = 6.4 ± 1.6 vs. M = 3.7 ± 0.7) and depression symptoms (M = 6.7 ± 1.6 vs. M = 3.8 ± 0.9), those reduced significantly after HIIT. After a 30-day detraining period, there was an increase in the significant change in the quality of life; however, domains of mental health showed instability. In summary, the HIIT program promoted improvements in the quality of life and mental health in women with PCOS. The 30 days of detraining changed the benefits in the quality of life and stability in the changes in mental health domains.
Exogenous Ca2+ priming can improve peanut photosynthetic carbon fixation and pod yield under early sowing scenarios in the field
Authors: Song Qiaobo , Zhang Siwei , Bai Chunming , Shi Qingwen , Wu Di , Liu Yifei , Han Xiaori , Li Tianlai , Yong Jean Wan Hong
Published: September 2022

Harnessing cold-resilient and calcium-enriched peanut production technology are crucial for high-yielding peanut cultivation in high-latitude areas. However, there is limited field data about how exogenous calcium (Ca2+) application would improve peanut growth resilience during exposure to chilling stress at early sowing (ES). To help address this problem, a two-year field study was conducted to assess the effects of exogenous foliar Ca2+ application on photosynthetic carbon fixation and pod yield in peanuts under different sowing scenarios. We measured plant growth indexes, leaf photosynthetic gas exchange, photosystems activities, and yield in peanuts. It was indicated that ES chilling stress at the peanut seedling stage led to the reduction of Pn, gs, Tr, Ls, WUE, respectively, and the excessive accumulation of non-structural carbohydrates in leaves, which eventually induced a chilling-dependent feedback inhibition of photosynthesis due mainly to weaken growth/sink demand. While exogenous Ca2+ foliar application improved the export of nonstructural carbohydrates, and photosynthetic capacity, meanwhile activated cyclic electron flow, thereby enhancing growth and biomass accumulation in peanut seedlings undergoing ES chilling stress. Furthermore, ES combined with exogenous Ca2+ application can significantly enhance plant chilling resistance and peanut yield ultimately in the field. In summary, the above results demonstrated that exogenous foliar Ca2+ application restored the ES-linked feedback inhibition of photosynthesis, enhancing the growth/sink demand and the yield of peanuts.
Soil applied silicon and manganese combined with foliar application of 5-aminolevulinic acid mediate photosynthetic recovery in Cd-stressed Salvia miltiorrhiza by regulating Cd-transporter genes
Authors: Sun Yuee , Li Xin , Najeeb Ullah , Hou Zhuoni , Buttar Noman Ali , Yang Zongqi , Ali Basharat , Xu Ling
Published: September 2022

Salvia miltiorrhiza is an important medicinal plant that experiences significant growth and biomass losses when cultivated on cadmium (Cd) contaminated soils. High Cd accumulation in plant tissues also increases the risk of metal entry into the food chain. In this study, we proposed that Cd accumulation in S. miltiorrhiza can be restricted through plant growth regulators and nutrient management. Therefore, S. miltiorrhiza seedlings were transplanted into mixed nutrient soil for two weeks, then treated with 30 mg kg-1 CdCl2, 200 mg kg-1 Na2SiO3·9H2O, and 100 mg kg-1 MnSO4, and simultaneously sprayed with 10 mg L-1 ALA on the leaves one week later. This study showed that elevated Cd accumulation significantly reduced plant growth and biomass. This growth inhibition damaged photosynthetic machinery and impaired carbon assimilation. In contrast, 5-aminolevulinic acid (ALA) significantly promoted the biomass of S. miltiorrhiza, and the dry weight of plants treated with ALA combined with manganese (Mn)/silicon (Si) increased by 42% and 55% as compared with Cd+Mn and Cd+Si treatments. Exogenously applied ALA and Si/Mn significantly activated antioxidant enzymes and promoted the growth recovery of S. miltiorrhiza. Further, exogenous ALA also reduced the Cd concentration in S. miltiorrhiza, especially when combined with Si. Compared with the Cd+Si treatment, the Cd+Si+ALA treatment reduced the Cd concentration in roots and leaves by 59% and 60%, respectively. Gene expression analysis suggested that ALA and Si significantly up-regulated genes associated with Cd transport. Other genes related to heavy metal tolerance mechanisms are also regulated to cope with heavy metal stress. These results indicated that the combined action of ALA and Si/Mn could reduce Cd-toxicity by increasing chlorophyll content and changing oxidative stress and can also affect Cd accumulation by regulating gene expression.
Non-targeted metabolomic analysis for the comparative evaluation of volatile organic compounds in 20 globally representative cucumber lines
Authors: Jo Hyo Eun , Song Kihwan , Kim Jeong-Gu , Lee Choong Hwan
Published: September 2022

Volatile organic compounds (VOCs) are one of the main fruit-quality determinants in cucumber. Here, we investigated the differences in the VOC and primary metabolite composition among 20 representative cucumber lines. Results of non-targeted metabolomics revealed that the cucumber breeding line of the Korean group showed a unique VOC composition in the fruit peel compared to the other groups. Fruit-flesh VOCs significantly differed among Korean, European, and Thai fruits. The main cucumber flavor components, 2-hexenal, hexanal, 6-nonenal, 2,4-nonadienal, and 2,6-nonadienal, were lower in the Korean cucumber lines than in the others. Conversely, linoleic acid derivatives and α-linolenic acid, which are precursors of these VOCs, were abundant in Korean cucumber line. This suggests that the metabolism related to the characteristic flavor of cucumber are downregulated in Korean cucumber line. This study provides novel insights into the fruit flavor-associated metabolome in various cucumber lines.
Salt stress in olive tree shapes resident endophytic microbiota
Authors: Vita Federico , Sabbatini Leonardo , Sillo Fabiano , Ghignone Stefano , Vergine Marzia , Guidi Nissim Werther , Fortunato Stefania , Salzano Anna Maria , Scaloni Andrea , Luvisi Andrea , Balestrini Raffaella , De Bellis Luigi , Mancuso Stefano
Published: September 2022

Olea europaea L. is a glycophyte representing one of the most important plants in the Mediterranean area, both from an economic and agricultural point of view. Its adaptability to different environmental conditions enables its cultivation in numerous agricultural scenarios, even on marginal areas, characterized by soils unsuitable for other crops. Salt stress represents one current major threats to crop production, including olive tree. In order to overcome this constraint, several cultivars have been evaluated over the years using biochemical and physiological methods to select the most suitable ones for cultivation in harsh environments. Thus the development of novel methodologies have provided useful tools for evaluating the adaptive capacity of cultivars, among which the evaluation of the plant-microbiota ratio, which is important for the maintenance of plant homeostasis. In the present study, four olive tree cultivars (two traditional and two for intensive cultivation) were subjected to saline stress using two concentrations of salt, 100 mM and 200 mM. The effects of stress on diverse cultivars were assessed by using biochemical analyses (i.e., proline, carotenoid and chlorophyll content), showing a cultivar-dependent response. Additionally, the olive tree response to stress was correlated with the leaf endophytic bacterial community. Results of the metabarcoding analyses showed a significant shift in the resident microbiome for plants subjected to moderate salt stress, which did not occur under extreme salt-stress conditions. In the whole, these results showed that the integration of stress markers and endophytic community represents a suitable approach to evaluate the adaptation of cultivars to environmental stresses.
Functions of autophagy in chloroplast protein degradation and homeostasis
Authors: Wan Chen , Ling Qihua
Published: September 2022

Chloroplasts are defining organelles in plant and algae, which carried out various critical metabolic processes, including photosynthesis. Roles of chloroplast protein homeostasis in plant development and stress adaptation were clearly demonstrated in previous studies, and its maintenance requires internal proteases originated from the prokaryotic ancestor. Recently, increasing evidence revealed that eukaryotic proteolytic pathways, ubiquitin-proteasome system (UPS) and autophagy, are also involved in the turnover of chloroplast proteins, in response to developmental and environmental cues. Notably, chloroplasts can be regulated via the selective degradation of chloroplast materials in a process called chlorophagy. Yet, understandings of the mechanism of chlorophagy are still rudimentary, particularly regarding its initiation and operation. Here we provide an updated overview of autophagy pathways for chloroplast protein degradation and discuss their importance for plant physiology. In addition, recent advance in analogous mitophagy in yeast and mammals will also be discussed, which provides clues for further elucidating the mechanism of chlorophagy.
Genetic control of the lateral petal shape and identity of asymmetric flowers in mungbean (Vigna radiata L.)
Authors: Li Xin , Sun Mingzhu , Jia Yahui , Qiu Dan , Peng Qincheng , Zhuang Lili
Published: September 2022

Broad diversity of flowers in Fabaceae provides a good system to investigate development and evolution of floral symmetry in higher plants. Many studies have demonstrated a conserved mechanism controlling development of zygomorphic flower during last decades. However, the molecular basis of how asymmetric flower established is largely unknown. In this study, we characterized mutants named keeled wings (kw) in mungbean (Vigna radiata L.), which is a legume species with asymmetric flowers. Compared to those in the wild type plants, the lateral petals were ventralized in the kw mutants. Map-based cloning showed that KW was VrCYC3 gene in mungbean, the ortholog of Lotus japonicus CYC3 (LjCYC3) and Pisum sativum CYC3 (PsCYC3). In addition, another two CYC-like genes named VrCYC1 and VrCYC2 were identified from mungbean genome. The three CYC-like genes displayed distinct expression patterns in dorsal, lateral and ventral petals. It was found that VrCYC3 was located in nucleus. Further analysis showed that VrCYC3 had transcription activity and could interact with VrCYC1 and VrCYC2 in yeast cell. Moreover, the deletion of two amino acid residues in the R domain of VrCYC3 protein could decrease its interaction with VrCYC1 and VrCYC2 proteins. Our results suggest that LjCYC3/VrCYC3 orthologs play conserved roles determining the lateral petal shape and identity of zygomorphic flower as well as asymmetric flower in Papilionoideae.
A literature review of the research on students’ evaluation of teaching in higher education
Authors: Zhao Luying , Xu Pei , Chen Yusi , Yan Shuangsheng
Published: September 2022

Students’ evaluation of teaching is a teaching quality evaluation method and teacher performance evaluation tool commonly used in Chinese and foreign universities, and it is also a controversial hot issue in the field of teaching evaluation. At present, the research results of students’ evaluation of teaching in higher education are relatively rich, mainly focusing on reliability, validity and its influencing factors, construction of index system, problems in practical application and improvement strategies. The purpose of this article is to study the relevant research results of the current Chinese and foreign academic circles, in order to provide useful inspiration for the construction of the index system and practical application of the ideological and political theory course evaluation and teaching of Chinese college students.
Influence of anxiety on university students’ academic involution behavior during COVID-19 pandemic: Mediating effect of cognitive closure needs
Authors: Yan Dongdong , Zhang Huanzhe , Guo Shili , Zeng Wen
Published: September 2022

The COVID-19 pandemic has had a significant negative effect on university students’ mental health worldwide. The pandemic has resulted in individuals experiencing increased levels of anxiety and stress as well as intensified concerns about the future due to a rise in uncertainty. To eliminate the anxiety and stress caused by uncertainty, individuals who have high cognitive closure needs are strongly motivated to achieve certainty and seek answers, even if the decisions they make in the process are inappropriate or even irrational. This study attempts to analyze the influence of anxiety and stress on university students’ academic involution behavior during the COVID-19 pandemic through the mediating effect of the need for cognitive closure. Analyzing the survey data collected from 402 university students from 3 different universities through the mediating effect model and path analysis with latent variable (PA-LV), our results indicate that: (1) The COVID-19 pandemic has significantly increased the levels of anxiety and stress experienced by university students. The path coefficient of the perceived risk of contracting COVID-19 to perceived emotions (including anxiety and stress) was 0.352 (p < 0.01), (2) anxiety and stress significantly and positively affect academic involution behavior. For each unit of increase in the scores of anxiety and stress, the scores of academic involution behavior increased by 0.408 (p < 0.01) and 0.398 (p < 0.01) units, respectively, and (3) The need for cognitive closure had a complete and partial mediating effect on the relationship between the perceived risk of contracting COVID-19 and academic involution behavior, as well as anxiety and academic involution behavior, respectively. The results of PA-LV showed that the mediating effect values were 0.106 and 0.044, respectively. The impact of the COVID-19 pandemic has not yet come to an end and so clarifying the relationship between anxiety and academic involution behavior will assist university students to optimize the relationship in their own subjective situations, to establish good learning habits, and reduce psychological distress.
Being targeted: How counter-arguing and message relevance mediate the effects of cultural value appeals on disease prevention attitudes and behaviors
Authors: Yan Xiaodi
Published: September 2022

This study investigated the effects of cultural value appeals in health persuasion. Situated in the COVID-19 pandemic, this study examined if and how individualistic and collectivistic appeals can improve attitudes and behaviors related to the use of face masks among European Americans and Asian Americans. Results showed that for European Americans, collectivistic vs. individualistic appeals were more effective to improve attitudes and behavioral intention. Perceived message relevance and counter-arguing were significant mediators explaining the effects. For Asian Americans, both individualistic and collectivistic appeals predicted significant changes in attitudinal and behavioral outcomes. These findings have important theoretical and practical implications.
Interplay of eco-friendly factors and islamic religiosity towards recycled package products: A cross-cultural study
Authors: Zhang Qingyu , Husnain Mudassir , Usman Muhammad , Akhtar Muhammad Waheed , Ali Saqib , Khan Mussadiq Ali , Abbas Qamar , Ismail Riffat , Rehman Tayyab , Akram Muhammad
Published: September 2022

Climate change has increasingly been recognised and associated with consumer behaviour: Practitioners are developing their strategies to reduce environmental degradation while increasing the management of sustainable consumption; it needs to better understand consumer attitudes and eco-friendly factors about the issue. Therefore, the current study focused to understand the effects of pro-environmental factors on individuals’ environmental attitudes (purchase behaviour towards products with recycled packaging) through the lens of theory of planned behaviour in a cross-cultural setting. Moreover, present research focuses on the moderating role that religiosity plays in causal pathways between certain determinants (attitude, subjective norms, and perceived behavioural control) and intentions in this context. A multi-wave time-lagged research design was employed in this study, and university students from two developing countries were surveyed (N = 324, 266). The findings revealed pronounced similarities between the two examined countries. Overwhelmingly, pro-environmental factors examined (environmental values, environmental knowledge, and environmental concern) were found to be positively related to attitude formation. Further results showed that attitude and subjective norms are significant predictors of the intention to purchase products with recycled packaging. Moreover, with the exception of perceived behavioural control, religiosity moderates the relationships between all the determinants of TPB and intention to purchase recycled packaged products. Present study offers insightful implications to management of these emerging and/or similar cultural markets regarding customer value for green products. Using TPB, present study broadened and deepen extant stream of literature on consumption of recycled packaged products in two highly emerging markets; Pakistan and Malaysia.
Factors associated with academic resilience in disadvantaged students: An analysis based on the PISA 2015 B-S-J-G (China) sample
Authors: Jin Songli , Fang Guangbao , Cheung Kwok Cheung , Sit Pou Seong
Published: September 2022

Academic resilience is evident in students who are living in vulnerable environments, yet achieve success in academic outcomes. As a result, substantial attention has been devoted to identifying the factors associated with academic resilience and supporting students to be resilient. This study used the Classification and Regression Tree and Multilevel Logistic Regression modeling to identify the potential factors related to students’ academic resilience. Using these tools, the study analyzed the B-S-J-G (China) sample in PISA 2015. The variables that significantly predicted whether a student is disadvantaged and resilient (DRS) or not resilient (DNRS) were shown to be: Proportion of teachers in school with master’s degrees, Proportion of teachers in school with bachelor’s degrees, Environmental awareness, Science learning time per week, Number of learning domains with additional instruction, and Students’ expected occupational status. These findings may enlighten governments, teachers, and parents on ways to assist students to be resilient.
A one-hour walk in nature reduces amygdala activity in women, but not in men
Authors: Sudimac Sonja , Kühn Simone
Published: September 2022

Urban dwellers are more likely to develop mental disorders such as mood and anxiety disorder as well as schizophrenia compared to rural dwellers. Moreover, it has been demonstrated that even short-term exposure to nature can improve mood and decrease stress, but the underlying neural mechanisms are currently under investigation. In the present intervention study we examined the effects of a one-hour walk in an urban vs. natural environment on activity in the amygdala, a brain region previously associated with stress processing. Before and after the walk 63 participants underwent an fMRI paradigm inducing social stress. Since there is a pronounced gap in the literature regarding interindividual differences in stress-related neural effects of urban and natural environments, we set out to explore sex differences. We observed that amygdala activity decreased after the walk in nature, but only in women, suggesting that women may profit more from salutogenic effects of nature. Moreover, performance on the arithmetic tasks improved in women after the walk in nature, whereas men performed better after the walk in the urban environment. To our knowledge, this is the first study to report differencial tendencies in men and women concerning the stress-related neural activity as an effect of acute exposure to urban vs. natural environments. Furthermore, our findings highlight the importance of sex differences when exploring effects of the environment on brain function and stress. Evidence for beneficial effects of nature on stress-related brain regions may inform urban design policies to focus on providing more accessible green areas in cities and this study suggests that sex differences in experiencing the environment should be taken into consideration.
How prosocial behaviors are maintained in China: The relationship between communist authority and prosociality
Authors: Sheng Jing , Luo Shuilian , Jiang Bo , Hu Yousong , Lin Shuang , Wang Li , Ren Yashi , Zhao Chunling , Liu Zixin , Chen Jun
Published: September 2022

Objective

Numerous studies have demonstrated that religious belief is associated with prosocial behavior. However, how do they maintain cooperation in societies with a predominating atheist population, such as China? Different primings (explicit, subliminal, implicit) and a quasi-experiment are used to examine the link between communist authority and prosocial behaviors among college students in China.

Materials and methods

In Study 1 (N = 398), the subjects’ communist authority in the university lab was primed by a communist-authority video. In Study 2 (N = 296), we compared the priming effects of communist authority and religion on prosocial intention. Study 3 (N = 311) investigated the priming effect of communist authority on prosocial behaviors by employing a scrambled sentence task in the university lab. A quasi-experiment was conducted in Study 4 (N = 313).

Results

Results showed that communist-authority, a reminder of secular authorities, increased prosociality among college students. And empathy moderated the relationship between secular authorities and prosociality in Study 3 and Study 4.

Discussion

Communist authority, a secular authority prime, has a positive effect on promoting prosocial behaviors. These results provided a feasible yet novel way to reveal the mechanism of the relationship between secular authorities and prosociality in China.
I looked at you, you looked at me, I smiled at you, you smiled at me—The impact of eye contact on emotional mimicry
Authors: Mauersberger Heidi , Kastendieck Till , Hess Ursula
Published: September 2022

Eye contact is an essential element of human interaction and direct eye gaze has been shown to have effects on a range of attentional and cognitive processes. Specifically, direct eye contact evokes a positive affective reaction. As such, it has been proposed that obstructed eye contact reduces emotional mimicry (i.e., the imitation of our counterpart’s emotions). So far, emotional mimicry research has used averted-gaze faces or unnaturally covered eyes (with black censor bars) to analyze the effect of eye contact on emotional mimicry. However, averted gaze can also signal disinterest/ disengagement and censor bars obscure eye-adjacent areas as well and hence impede emotion recognition. In the present study (N = 44), we used a more ecological valid approach by showing photos of actors who expressed either happiness, sadness, anger, or disgust while either wearing mirroring sunglasses that obstruct eye contact or clear glasses. The glasses covered only the direct eye region but not the brows, nose ridge, and cheeks. Our results confirm that participants were equally accurate in recognizing the emotions of their counterparts in both conditions (sunglasses vs. glasses). Further, in line with our hypotheses, participants felt closer to the targets and mimicked affiliative emotions more intensely when their counterparts wore glasses instead of sunglasses. For antagonistic emotions, we found the opposite pattern: Disgust mimicry, which was interpreted as an affective reaction rather than genuine mimicry, could be only found in the sunglasses condition. It may be that obstructed eye contact increased the negative impression of disgusted facial expressions and hence the negative feelings disgust faces evoked. The present study provides further evidence for the notion that eye contact is an important prerequisite for emotional mimicry and hence for smooth and satisfying social interactions.
Validation of L2 grit among Chinese EFL high school students and its enduring effect on achievements: A bifactor model approach
Authors: Liu Eerdemutu , Wang Junju , Bai Sachurina
Published: September 2022

The current study seeks to validate L2 grit measure among 637 Chinese senior middle school students using a bifactor modeling approach. To do so, we first assessed and compared four alternative measurement models including CFA, bifactor CFA, ESEM, and bifactor ESEM models. Among these models, CFA exhibited the poorest fit to the data collected from the sample. ESEM showed partial fit to the data with a slightly lower factor correlation between two components of L2 grit (i.e., perseverance of effort and consistency of interest) than CFA. Two bifactor models (bifactor CFA and bifactor ESEM) demonstrated excellent fits to the data. The more parsimonious bifactor CFA model was selected as the optimal one. Based on the bifactor CFA model, we confirmed measurement invariance across gender and predictive validity of L2 grit on subsequent language achievements. Based on these findings, methodological and pedagogical implications were discussed.
How much vocabulary is needed for comprehension of video lectures in MOOCs: A corpus-based study
Authors: Xodabande Ismail , Ebrahimi Hourieh , Karimpour Sedigheh
Published: September 2022

Over the past years, Massive Open Online Courses (MOOCs) have emerged as new competitive advantages in the digital economy of higher education globally. Accordingly, an increasing number of individuals are attracted to these new learning environments for developing their knowledge and skills in a variety of subject areas. Despite these developments, research on linguistic features of MOOCs lectures as the main mediums for delivering the course contents remained limited. To address this gap, the present study analyzed a corpus of MOOCs lectures with around 4.45 million words to determine the size of vocabulary knowledge needed for 95 and 98% coverages. The findings revealed that sufficient coverage of the course contents requires knowledge of the 5,000 most frequent words in English. Nonetheless, achieving adequate coverage level requires a much larger vocabulary size of around 9,000 most frequent words in English. The study also found that widely used word lists for general and academic vocabulary (i.e., the GSL/AWL) fail to support MOOCs learners with sufficient vocabulary knowledge for adequate lexical coverage. Based on these findings, the study draws a number of implications for preparing non-native English speakers to use MOOCs effectively and setting research-informed vocabulary learning goals in instructional programs and materials.
Understanding the relationships between teacher mindfulness, work engagement, and classroom emotions
Authors: Tao Wei
Published: September 2022

This cross-sectional study investigated the relationships between teacher mindfulness, work engagement, and classroom emotions composed of positive and negative emotions. A sample of 498 Chinese primary, secondary, and high school teachers completed an anonymous online questionnaire. Descriptive analysis, bivariate correlation, and a series of regression equations were conducted to analyze the data. The results indicate that teacher mindfulness, work engagement, and classroom emotions are all at the intermediate level, and significantly correlated. The effect of teacher mindfulness on classroom emotions is partially mediated by work engagement. In addition, negative emotions partially mediate the effect of teacher mindfulness on work engagement, while positive emotions fully mediate it. These results highlight the importance of fostering teacher mindfulness through mindfulness-based intervention, developing teacher emotion regulation competence in teacher education, and cultivating supportive classroom and school culture for teachers to experience more positive emotions from students and administrators.
Popularity of the metaverse: Embodied social presence theory perspective
Authors: Zhang Guihua , Cao Junwei , Liu Dong , Qi Jie
Published: September 2022

With Facebook’s name changing to Meta, the metaverse concept has become popular again. There are many indications that the current fashionableness of the metaverse is not driven by technical factors, rather related to the public hype. To clarify the reasons for the increasing popularity of the concept, this study develops a model based on embodied social presence theory. We surveyed 292 metaverse users, and analyzed the obtained data using partial least squares structural equation modeling (PLS-SEM). The results show that the main technical factors influencing the metaverse popularity do not significantly predict users’ embodied presence and embodied co-presence, while users’ imagination positively predicts their embodied presence in the metaverse and positively influences users’ willingness to continuously participate through the multiple mediating effects of embodied presence and co-presence. The results of this study confirm, to some extent, that user imagination triggered by public opinion drives the popularity of the metaverse.
Effects of semantic clustering and repetition on incidental vocabulary learning
Authors: Pérez-Serrano Mercedes , Nogueroles-López Marta , Duñabeitia Jon Andoni
Published: September 2022

The present study intended to investigate, first, the impact of semantic clustering on the recall and recognition of incidentally learned words in a new language, and second, how the interaction between semantic clustering and frequency of occurrence may modulate learning. To that end, Spanish university students watched an intentionally created video which contained Spanish target words that were either semantically related to others of the set, or not semantically linked at all. Furthermore, frequency of appearance changed among target words (1|4|8). All these words were paired with pseudowords that appeared as on-screen text during the videos. Participants were completely naive to the phases and the procedure of the experiment. After viewing the video, participants completed a recall test and a recognition test. Results showed that words presented in semantically unrelated categories were better recalled and better recognized than those presented in semantic clusters, especially when the words were presented more often.
Abnormal degree centrality in first-episode medication-free adolescent depression at rest: A functional magnetic resonance imaging study and support vector machine analysis
Authors: Guo Xin , Wang Wei , Kang Lijun , Shu Chang , Bai Hanpin , Tu Ning , Bu Lihong , Gao Yujun , Wang Gaohua , Liu Zhongchun
Published: September 2022

Background

Depression in adolescents is more heterogeneous and less often diagnosed than depression in adults. At present, reliable approaches to differentiating between adolescents who are and are not affected by depression are lacking. This study was designed to assess voxel-level whole-brain functional connectivity changes associated with adolescent depression in an effort to define an imaging-based biomarker associated with this condition.

Materials and methods

In total, 71 adolescents affected by major depressive disorder (MDD) and 71 age-, sex-, and education level-matched healthy controls were subjected to resting-state functional magnetic resonance imaging (rs-fMRI) based analyses of brain voxel-wise degree centrality (DC), with a support vector machine (SVM) being used for pattern classification analyses.

Results

DC patterns derived from 16-min rs-fMRI analyses were able to effectively differentiate between adolescent MDD patients and healthy controls with 95.1% accuracy (136/143), and with respective sensitivity and specificity values of 92.1% (70/76) and 98.5% (66/67) based upon DC abnormalities detected in the right cerebellum. Specifically, increased DC was evident in the bilateral insula and left lingual area of MDD patients, together with reductions in the DC values in the right cerebellum and bilateral superior parietal lobe. DC values were not significantly correlated with disease severity or duration in these patients following correction for multiple comparisons.

Conclusion

These results suggest that whole-brain network centrality abnormalities may be present in many brain regions in adolescent depression patients. Accordingly, these DC maps may hold value as candidate neuroimaging biomarkers capable of differentiating between adolescents who are and are not affected by MDD, although further validation of these results will be critical.
Examination of the importance of anger/irritability and limited prosocial emotion/callous-unemotional traits to understand externalizing symptoms and adjustment problems in adolescence: A 10-year longitudinal study
Authors: Urben Sébastien , Habersaat Stéphanie , Palix Julie , Fegert Jörg M. , Schmeck Klaus , Bürgin David , Seker Süheyla , Boonmann Cyril , Schmid Marc
Published: September 2022

Objective

Within a longitudinal study (10-year follow-up), we aim to examine the role of anger/irritability and limited prosocial emotion/callous-unemotional traits in predicting externalizing symptoms and adjustment problems in individuals formerly in youth residential care institutions.

Method

These dimensions were assessed in 203 young adults, with baseline assessments during youth residential care and a follow-up 10 years later.

Results

In general, emotional problems and psychopathological symptoms did not reduce over time. Analyses of regression revealed that a younger age at baseline, anger/irritability both at baseline assessment, and regarding their aggravation over time refer to significant predictors of the level of externalizing symptoms at 10-year follow-up (R2 = 0.431) and the worsening of externalizing symptoms over time (R2 = 0.638). Anger/irritability has been observed to be a significant predictors of both the level of adjustment problems at 10-year follow-up (R2 = 0.471) and its worsening over time (R2 = 0.656).

Discussion

Our results suggest that dysregulation of anger/irritability is a key factor in the prediction of long-term externalizing symptoms and adjustment problems as well as its worsening over time. Possible implications for intervention and prevention are discussed.
Influence of positive and negative affect on self-management among patients with early chronic kidney disease during the COVID-19 pandemic: The mediating and suppressing effect of ego depletion
Authors: Cui Yi , Li Rong , Yang Tianqi , Wang Hua , Jin Shasha , Liu Na , Liu Hongbao , Zhang Yinling
Published: September 2022

Background

Self-management in patients with early chronic kidney disease (CKD) can effectively delay damage to renal function. However, with the continuous spread of COVID-19, patients cannot receive timely treatment, which can lead to different affects, resulting in ego depletion and serious challenges to self-management. This study aimed to investigate the mediating and suppressing roles of ego depletion on the relationship between positive and negative affect and self-management among patients with early CKD during the COVID-19 pandemic in China.

Methods

A total of 383 patients with early CKD from three tertiary hospitals were enrolled by convenience sampling in our cross-sectional study from September 2021 to March 2022. Participants completed the Sociodemographic Questionnaire, Positive Affect and Negative Affect Scale, Self-Regulating Fatigue Scale and Chronic Kidney Disease Self-Management Instrument. A structural equation model was conducted to test the mediating and suppressing effects of ego depletion on the relationship between positive and negative affect and self-management.

Results

The average score of the participants' self-management was 84.54 (SD: 19.72), and nearly 60% of them were at low and moderate levels. The mediating effect of positive affect on self-management through ego depletion was significant (β = 0.248, 95% CI: 0.170 to 0.376), accounting for 53.22% of the total effect. The suppressing effect of negative affect on self-management through ego depletion was significant (β = −0.191, 95% CI: −0.310 to −0.118), and the absolute value of the ratio of the suppressing effect to the direct effect was 66.55%.

Conclusions

Ego depletion partially mediated the relationship between positive affect and self-management while suppressing the relationship between negative affect and self-management among patients with early CKD during the COVID-19 pandemic. The reduction of patients' ego depletion must be taken as the intervention target to improve self-management and delay the progression of CKD.
Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China
Authors: Zhou Yanyan , Wu Chenfang , Ouyang Lin , Peng Ying , Zhong Dingming , Xiang Xiaohong , Li Jinxiu
Published: September 2022

oXiris is a new, high-adsorption membrane filter in continuous hemofiltration adsorption to reduce the inflammatory response in sepsis. The investigators retrospectively reviewed patients with sepsis/septic shock who underwent at least one oXiris-treatment from November 2020 to March 2022. The demographic data, baseline levels before treatment, clinical datas, prognosis, and the occurrence of adverse events during treatment were recorded. 90 patients were enrolled in this study. The hemodynamic indices, sequential organ failure assessment score, lactate, inflammatory biomarkers levels were significantly improved at 12 h and 24 h after treatment. Procalcitonin and interleukin-6 reduction post-treatment of oXiris were most pronounced in infection from skin and soft tissue, urinary and abdominal cavity. Logistic regression analysis showed that pre-treatment sequential organ failure assessment score (p = 0.034), percentage decrease in sequential organ failure assessment score (p = 0.004), and age (p = 0.011) were independent risk factors for intensive care unit mortality. In conclusion, oXiris-continuous hemofiltration adsorption may improve hemodynamic indicators, reduce the use of vasoactive drugs, reduce lactate level and infection indicators. Of note, oXiris improve organ function in sepsis, which may result to higher survival rate.