bluuebunny/crossref_metadata_2025 huggingface dataset:
Percutaneous creation of direct intrahepatic portosystemic shunts – an alternative for failed TIPS creation
Authors: Mostafa Karim , Trentmann Jens , Andersson Julian , Günther Rainer , Braun Felix , Schäfer Philipp Jost
Published: March 2022

Introduction

Direct intrahepatic portosystemic shunt creation is a feasible and safe alternative for transjugular intrahepatic portosystemic shunt creation. It needs equipment like endovascular ultrasound with restricted availability. We performed the procedure percutaneously with a common interventional armamentarium to make it more feasible.

Methods

Retrospective analysis of 8 percutaneous DIPS insertions between 2016 and 2020.

Results

The procedure was successful in 8/8 patients. There was no short-term death reported within 30 days. The longest reported patency is 5 years.

Conclusion

Percutaneous DIPS creation is a feasible alternative for failed TIPS. Percutaneously the procedure can be completed faster than conventional DIPS using only minimal puncture equipment.

Level of evidence

Level 4, Case Series.
Differential expression of microRNAs targeting genes associated with the development of high-grade gliomas
Authors: Kit Oleg I. , Pushkin Anton A. , Alliluyev Ilya A. , Timoshkina Nataliya N. , Gvaldin Dmitry Y. , Rostorguev Eduard E. , Kuznetsova Nataliya S.
Published: March 2022

Background

Highly malignant high-grade gliomas are tumors of the central nervous system (CNS). They are solid tumors arising from transformed cells of the brain and/or the spinal cord. In recent years, the expression of genes and regulating miRNAs in glial brain tumors has been actively studied. The present study is devoted to assessing the expression levels of miR-215-5p, miR-22-3p, miR-122-5p, miR-107, miR-324-5p, miR-34a-5p, miR-155. -5p, miR-21-5p, miR-497-5p, miR-330-3p, miR-146a-5p, miR-92a-1-5p, miR-326 and target genes EGFR, SMAD4, SMAD7, SMO, NOTCH1, NOTCH2, HIF1A, EGLIN1/3, KDM1B, KDM1A, MSI1, MSI2, TET1 in high-grade glioma tissues.

Results

As a result of the analysis of the levels of relative expression of the studied genes, there are significant changes (p < 0.05) in tumor tissue for genes: EGFR, SMAD4, SMAD7, SMO, HIF1A, EGLN1/3. We obtained data on a significant change (p < 0.05) in the levels of relative expression for microRNA: hsa-miR-215-5p, hsa-miR-22-3p, hsa-miR-122-5p, hsa-miR-107, hsa-miR-324-5p, hsa-miR-155-5p, hsa-miR-21-5p, hsa-miR-330-3p, hsa-miR-326. Data on the association of overall survival in patients with high-grade glioma and the level of relative expression of the EGFR and HIF1A genes were obtained. The obtained data demonstrate the association of overall survival of patients with high-grade glioma and the level of relative expression of EGFR, HIF1A and hsa-miR-22-3p, hsa-miR-107 and hsa-miR-330-3p.

Conclusions

The obtained data on the expression of genes and microRNAs expand the understanding of the biology of the development of high-grade glial tumors. These data demonstrate new potential therapeutic and prognostic goals in high-grade gliomas.
Factors affecting performance improvement of the metro system in cities
Authors: Aboul-Atta Tarek Abdel-latif , Elmaraghy Sally Bahaa eldin
Published: March 2022

The transportation sector is considered one of the most important sectors affecting the planning and development of cities. It is the responsible sector for traffic and transport inter- and intra-cities through the mass transit systems, which reflect the civilization, urban, economic, and social levels of cities. The importance of this study lies in studying the most important mass transit systems, namely the metro system, as stated unanimously by transport experts and urban planners. It is characterized by speed, safety, and punctuality. It avoids bus drawbacks such as slowness and mixing with other types of traffic. This research aims to find a set of criteria that contribute to improving metro performance and increasing its efficiency. In this paper, some standards were collected from 29 countries with metro systems that are considered successful as they meet the needs of their communities. Conducting the principal component analysis (PCA) and multiple regression analysis (MRA) has produced three mathematical equations to explain the impact of these standards in improving the performance and efficiency of the metro system. The results showed that there is no one set of specific standards among the countries around the world that could be sufficient to rely on to monitor and evaluate metro system performance, which requires further studying and research in this area.
Where does early years stand?
Authors: Allingham Sue
Published: March 2022

There seems to be a theme of confusion around the early years sector recently. This has long been the case, and if you have read my articles in this magazine over the years, I have often mentioned it.
Quiet please!
Authors: Goldenberg Gemma
Published: March 2022

Noise has been found to have a detrimental effect on children's performance in school, but how does this affect children in the early years where play, chatter and exploration is encouraged? Gemma Goldenberg looks into the impact of background noise on children's literacy learning and questions what can be done to mitigate the effects of this without compromising your pedagogical approach
Inclusion and individuality in PITM
Authors: Ephgrave Sian
Published: March 2022

This article is the fourth in a series of myth-busters on the topic of planning in the moment (PITM). In this piece I explain PITM's focus on individuality and inclusion.
What works?
Authors: Kent Julie
Published: March 2022

The value of a high-quality early years environment is central in supporting early communication and language. Julie Kent explores this from the baby room to the outdoors.
Communication, language and literacy: A focus on digital technology
Authors: Marycz Adam
Published: March 2022

Digital technology is part of our day to day lives, and certainly is part of children's learning of language and literacy. EYE editor, Angelica Celinska, recently hosted an Expert Panel Debate to explore the implications of digital technology on children's communication, language and literacy. Adam Marycz has summarised the recorded debate in this write-up.
Narratives in nature part 2
Authors: Norman Amanda
Published: March 2022

This second part of ‘Narratives in nature’ focuses on the journey rather than the destination of outdoor play with young children. Amanda reflects on the use of digital tablets in exploring children's views.
What is emotional literacy?
Authors: Penfold Sophie
Published: March 2022

In a world where mental health is becoming more common and awareness is growing, we need to be even more mindful of our youngest members of the population; children. A term often used in professional environments is the term emotional literacy (EL) or emotional intelligence (EI), however what does this term actually mean?
Beyond reading
Authors: Baker Charlotte
Published: March 2022

Charlotte Baker explores how to holistically approach reading time, looking at some of the possibilities of changing up reading activities in order to keep children's engagement high and to foster other types of learning; from using emotional intelligence to begin to understand how some of the characters are feeling to the sensory experiences of creating and using musical instruments.
It's time to talk about your bookshelf
Authors: Marycz Adam
Published: March 2022

As we celebrate books in the yearly tradition on 3rd March 2022 I think it's time we have a difficult conversation about the representation children witness on bookshelves everywhere
Grown-ups? Mum and Dad? Parents?
Authors: Marycz Adam
Published: March 2022

As Mother's Day fast approaches some schools have recently hit the headlines by ‘replacing the terms’ “mum and dad” with “grown-ups” when talking to children – so, I ask ‘is it time we were more considerate to individual children's family circumstances?’
British Values: Training is key
Authors: Gouldsboro Julia Maria
Published: March 2022

It is fantastic that the EYE magazine can be used as a platform for discussion and debate on British Values. From reading the articles by Jo Caswell, British values to please inspectors?, and Adam Marycz, Unpicking British Values, it is evident that there is ongoing need for discussion so that British Values are not only understood by practitioners but also become an intrinsic part of society.
Hapa-zome flower
Authors: White Hilary
Published: March 2022

Spring is the perfect time to introduce to your children the fascinating art of hapa-zome flower pounding; a lovely way to engage in mark making with nature.
Spring into movement!
Authors: White Hilary
Published: March 2022

Spring is the season of new life and exploring the movements of young animals in springtime is a great way for children to develop both gross and fine motor skills.
With a ‘spring’ in your step
Authors: Harries Judith
Published: March 2022

The fifth article in this series, exploring traditional nursery rhymes as a resource and inspiration for activities, focuses on literacy. These include: repeating simple rhymes, recognising and reading CVC (consonant, vowel, consonant) words, using writing frames and enjoying spring rhymes.
Copy, paste, legislate, succeed? The effect of policy plagiarism on policy success
Authors: Dorrell Robert M. , Jansa Joshua M.
Published: March 2022

Scholars and journalists have shown that US state legislators often copy and paste policy text from other sources. This ‘policy plagiarism’ is perceived by critics as symptomatic of process failures and likely to undermine policy success. To proponents, copy and paste legislation stems from an efficient learning process likely to guarantee policy success. The authors test competing hypotheses by measuring success and plagiarism across three areas of US state policy: organ donation legislation, e-cigarette/vaping bans for minors and anti-bullying legislation. They find that higher levels of plagiarism result in significantly less success at reducing youth vaping rates and increasing organ donor registrations. They also find a negative, though not significant, relationship between copying and success for antibullying policy. The evidence favours opponents: legislators risk harming policy success by copying from others. This study of policy plagiarism advances knowledge by moving beyond the simple demonstration of the phenomenon to investigate the potential link between the copying of legislative text and the extent to which the policies studied achieved their goals.
Development of loop-mediated isothermal amplification-lateral flow dipstick as a rapid screening test for detecting Listeria monocytogenes in frozen food products using a specific region on the ferrous iron transport protein B gene
Authors: Srisawat Wimvipa , Saengthongpinit Chalermkiat , Nuchchanart Wirawan
Published: March 2022

Background and Aim: Listeria monocytogenes is a critical foodborne pathogen that infects pregnant females and their newborns and older adults and individuals with comorbidities. It contaminates fresh vegetables, fruits, ready-to-eat foods, and frozen food products consumed by individuals. The culture conventional detection methods for L. monocytogenes are time-consuming, taking 4 days. This study aimed to describe the development and comparison of loop-mediated isothermal amplification (LAMP)- lateral flow dipstick (LFD), LAMP assay to PCR, and conventional culture for detecting L. monocytogenes in frozen food products.

Materials and Methods: Five LAMP primer sets, including F3, B3, forward inner primer, and backward inner primer, were designed from a specific region on ferrous iron transport protein B gene (feoB gene) to amplify LAMP products. The DNA probe was created, and the detection limit was determined in pure culture and purified DNA, as well as the detection in 20 frozen food product samples.

Results: The LMfeoB4 LAMP primer sets and DNA probe were LAMP products amplified at 60°C for 50 min. The specificity of the assay revealed no cross-reactivity with other pathogenic bacteria. The limit of detection (LOD) of the LAMP-LFD and LAMP assays using purified genomic DNA was 219 fg/μL both in LAMP and LAMP-LFD assays. The LOD of LAMP and LAMP-LFD assays in pure culture was 4.3×102 colony-forming unit (CFU)/mL and 43 CFU/mL, respectively. The LOD of the LAMP-LFD assay using artificially inoculated chicken in frozen food samples with pre-enrichment was 3.2×102 CFU/mL. The LAMP-LFD was also more sensitive than the LAMP assay and polymerase chain reaction. Finally, LAMP-LFD revealed no false positives in any of the 20 frozen food product samples.

Conclusion: LAMP-LFD assay using a specific region on the feoB gene to detect L. monocytogenes was highly specific, sensitive, faster, and convenient, making it a valuable tool for the monitoring and rapid screening of L. monocytogenes in frozen food products. This technique is applicable to the development of detection technologies for other pathogens in food products.
The effect of mycorrhizal species on the growth, essential oils, yield and morpho-physiological parameters of Lemon Balm (Melissa officinalis L.) under water-deficit conditions in Tabriz region
Authors: Shamizi Neda , Yarnia Mehrdad , Mohebalipour Nasser , Faramarzi Ali , Ajalli Jalil
Published: March 2022

Two years experiment were conducted in 2016-2017 as split-plot based on randomized completely block design with three replications to morpho-physiological responses of Lemon Balm (Melissa officinalis L.) plant to mycorrhizal fungi species treatments (control, Rhizophagus intraradices, Funneliformis mosseae, Glomus hoi and combined application of all three species) under different irrigation regimes (irrigation after 70, 100, 130 and 160 mm evaporation). In results, the highest oil yield was achieved in irrigation at 100mm+application of all three species of mycorrhizal fungi. Irrigation after 100 mm evaporation increased this trait by 33% compared to irrigation after 70 mm evaporation due to increase in essential oil percentage under dehydration conditions, however, increasing drought stress led to a significant decrease in essential oil yield. In terms of physiological parameters, dehydration led to an increase in proline content and antioxidant activates. In general and according to the results, modifying the destructive effects of water deficit stress and the use of mycorrhiza can increase the essential oil of lemon Balm. But aggravating water deficiency conditions can drastically reduce the essential oil yield. The founds could be helpful for herbal medicine researchers to achieve high-quality drugs.
Coupling MCNP6/ANSYS codes to calculate axial temperature and power distribution in a VVER-1000 fuel assembly
Authors: Refeat Riham M. , Refaey Ahmed M. , Abdel-Latif Salwa H.
Published: March 2022

The precise simulation of the reactor core either in steady state or during transients is very important for the safety assessment of nuclear power plants. This requires accurate determination of the parameters that influence the reactor operation. Coupling neutronic and thermal hydraulic schemes are developed to calculate these parameters. In the present paper, a coupling scheme between MCNP6 and ANSYS-FLUENT17.2 codes is proposed to obtain accurate radial and axial temperature distribution and hence pin power distribution for VVER-1000 fuel assembly. The Performance of the developed coupling scheme is investigated in steady state calculations. An iterative process is associated with the exchange of data between codes to meet the convergence criteria. The results obtained demonstrate that the proposed coupling scheme is able to simulate the VVER-1000 fuel assembly accurately. It gives information about thermal and neutronic behavior of the assembly and allows the feedback effects to be accurately modeled. This work is a step forward to establish a consistent methodology to be used in transient calculations.
Elementos asociados al idioma mapuzungun que facilitan y/u obstaculizan el proceso de aprendizaje del idioma inglés en estudiantes de origen mapuche
Authors: Del Valle Rojas Juan Alfredo , Soto Vallejos César Eduardo , Sandoval Tripailaf José Luis , Otárola Rodríguez Joaquín Eduardo , Valdés Guzmán Misael Andrés , Sanhueza Rodríguez Harold Hernán
Published: March 2022

El objetivo de esta investigación es determinar cuáles son los elementos asociados al idioma mapuzungun que facilitan u obstaculizan el aprendizaje del idioma inglés. En estesentido, son diversos los factores que influyen en el aprendizaje del inglés como un tercer idioma. En relación a los elementos ligados a la cultura mapuche, se encontraron elementos que pudieron haber facilitado y obstaculizado el aprendizaje del inglés. Los hallazgos permiten establecer que el elemento asociado al mapuzungun que facilitó el aprendizaje del inglés en los participantes es la Transferencia Lingüística, ya que este factor se identificó en cuatro de los seis casos. Ellos señalaron que al haber elementos parecidosentre los dos idiomas, aquello facilitó el proceso de aprendizaje del inglés. Igualmente, hubo otros factores que influyeron positivamente en el proceso de aprendizaje del inglés, tales como la Conciencia Metalingüística y factores socioculturales, los cuales se hallaron en tan sólo un caso. En cuanto a los factores asociados al mapuzungun que obstaculizaron el aprendizaje del inglés, se encontró que en la relación entre la cultura mapuche y occidental, existen elementos que obstaculizaron el proceso de aprendizaje en un participante. Por otra parte, se presentó el caso en el cual la diferencia de origen lingüístico del español, mapuzungun e inglés resultó ser un elemento obstaculizador en el aprendizaje del idiomainglés
Las retransmisiones televisivas como origen de nuevos requerimientos en la organización de los eventos
Authors: Montemayor Ruiz Francisco Javier
Published: March 2022

La organización de un evento mediático conlleva un complejo diseño. Conjugar las necesidades del responsable de la organización con los requerimientos del organismo encargado de la producción de la señal de televisión no siempre resulta una tarea fácil. La interacción entre los diferentes actores que intervienen en este proceso, el flujo de información en ambas direcciones y la coordinación necesaria para conseguir un consenso, facilitará la hoja de ruta en la consecución de un único objetivo comúnque lleve a conseguir el éxito conjunto. El objetivo de este trabajo pretende analizar el modus operandi que se establece entre el comité organizador y el organismo anfitrión de la retransmisión televisiva, al mismo tiempo que establece la hipótesis de que el responsable de protocolo se configura como aglutinador de todas las facetas en el diseño organizacional y constituye la piedra angular de la puesta en escena del evento y quien, junto a los responsables de las áreas de marketing, comunicación y seguridad, será el encargado de establecer las líneas maestras que servirán de base para crear y esbozar la filosofía de la cobertura televisiva.
Análisis del branded content en televisión: estudio de casos españoles
Authors: Castelló Martínez Araceli , Del Pino Romero Cristina
Published: March 2022

El branded content se ha popularizado como formato de comunicación corporativa y publicitaria alternativa a las acciones comunicacionales tradicionales. El presentetrabajo analiza el uso del branded content por parte de los anunciantes españoles en el medio televisión, con el fin de identificar las características de la aplicación de estatécnica al principal medio en inversión publicitaria en España. La metodología empleada se basa en el estudio de casos, analizando para cada uno de ellos una serie de variables previamente definidas. Los resultados muestran el carácter de utilidad y servicio que, en su mayoría, tienen las acciones de branded content difundidas en el medio televisión, ya que ofrecen información de interés para el ciudadano, como consejos y tutoriales, con un mensaje centrado en el destinatario, y transmitiendo a través de los contenidos los valores de la marca. Como conclusión, podemos destacar la transmedialidad que caracteriza a las acciones de branded ontent televisivas, puesto que la conversación entre marca y usuario sobre la temática tratada en estos espacios continúa en los medios sociales, a través de la presencia de los programas en plataformas como Twitter.
Social Media en el sector del enoturismo
Authors: Matellanes Lazo Mónica
Published: March 2022

Numerosas ciudades en España han visto ya las ventajas que reportan las actividades enológicas. Castilla y León se intenta posicionar como una comunidad ideal para el destino enoturístico, cultural y para la realización de eventos.La investigación que se muestra pretende dar a conocer el mundo del enoturismo y acercarlo a un mayor número de personas de forma llamativa e interactiva a través de la Comunicación online. Se trata de valorar la comunidad de Castilla y León como destino enoturístico a nivel nacional y mundial. Para ello se ha contactado con profesionales del sector para que ofrezcan sus opiniones y argumentaciones justificadas sobre la gestión de la Comunicación online en las bodegas de Castilla y León. Los resultados afirman que Internet y los Social Media son buenos para comunicar la cultura del vino.
La entrevista periodística como paradigma de un género dialógico: estudio del léxico en la prensa española
Authors: Oliva Marañón Carlos
Published: March 2022

La entrevista periodística constituye un fenómeno social contemporáneo caracterizado por el hecho de que un mensaje público es dirigido de forma indirecta a unos destinatarios dispares a través de los medios de comunicación. En este estudio se aborda la investigación del léxico de la entrevista periodística en la prensa española durante los años 2008 y 2009. Se estudian los antecedentes históricos de este género, sus definiciones, sus técnicas, la relación entre entrevistador y entrevistado y la ética profesional del periodista. Se ha seleccionado un conjunto de entrevistas publicadas en diarios de tirada nacional para investigar los diferentes tipos de lenguajes. Se constata el uso masivo del lenguaje coloquial, la Retórica, la presencia del lenguaje violento y la utilización de tópicos. Curiosidad, tolerancia, cautela, dominio del lenguaje, capacidad para escuchar y la combinación de técnicas cuantitativas y cualitativas son las aptitudes deseables en un periodista para realizar entrevistas con el máximo rigor.
Presencia de la información especializada en defensa en la red social Twitter. Cuentas oficiales de Twitter del Ministerio de Defensa y organismos militares, cuentas de periodistas especializados y cuentas de ciudadanos
Authors: De Ramón Carrión Manuel
Published: March 2022

Aunque con mayor retraso que en otros países de la OTAN y del resto de Occidente, las fuentes oficiales de la Defensa española han empezado ya a transmitir noticias a través de la Red Social Twitter y otras. Estas cuentas oficiales han llegado cuando los periodistas especializados en Defensa y otros ciudadanos hacía tiempo que estaban usando las redessociales. Sin embargo, a pesar del retraso, las fuentes oficiales de Defensa han convertido ya Twitter en un importante canal para difundir sus "flashes". El primer caso destacado se produjo en febrero y marzo de 2013, cuando la cuenta @Defensagob anunció que las tropas españolas habían comenzado el repliegue en algunas posiciones de Afganistán. El anuncio sirvió de aviso para todos los periodistas especializados en Defensa, pero también llegó directamente a todos los ciudadanos que siguen la cuenta oficial. Un claro caso "puenteo" del segundo eslabón comunicativo de la Cadena de la Comunicación (la Prensa) que anticipa el riesgo de que algún día las fuentes oficiales se conviertan en emisores directos de mensajes al tercer eslabón (el Público).
Synthesis and Potential Applications of Modified Xanthan Gum
Authors: Abu Elella Mahmoud H.
Published: March 2022

Designing high-performance adsorbents for wastewater treatment and antibacterial materials for food and biomedical applications and excellent drug carrier to prolong time retention of the therapeutic drug based on biodegradable polymers has gained more interest in recent years. Among these materials, xanthan gum, which is a natural polysaccharide and plays a vital role in various applications such as industry, enhanced oil recovery, water-based paints, pharmaceuticals, and personal care products because it has excellent properties such as biodegradability and non-toxicity. On the other hand, it has many affected limitations, including microbially attack, poor thermal and mechanical stability, and low surface area. So, in this review, we focused on the advanced modifications on xanthan gum and their applications in wastewater treatment, protein delivery, and designing antimicrobial materials.
Approach for Smart Use of Wastes and Biofuels
Authors: De Simio Luigi , Iannaccone Sabato
Published: March 2022

The urgent need to reduce greenhouse gas emissions by gradually abandoning fossil fuel sources is required due to climate-changing emergencies. Employing as much as possible renewable energy, in any form and any field, together with a reduction of per capita energy need, can reduce this tendency and contrast the catastrophic consequence of our planet temperature increasing. In this scenario, biofuels production, together with reuse and recycling represent a correct strategy to contrast environmental degradation. Biofuel has been the subject of great interest over the past decade. Their development from the first to the fourth generation has led to significant improvements in the production cycles and extended the interest in new resources. The availability of different choices could permit to use always the best solution to maximize the result.
In this paper, the different biofuel generations are presented with the aim of highlighting strengths and weaknesses to identify a smart approach to energy conversion and land utilization. Even today the first-generation biofuels are the most widespread, while second-generation gives a small contribution, with a low replacement share of fossil fuels. Land use and competition with other human necessities are the most relevant constraints in this evaluation. In general, the production of gaseous fuels requires less energy than liquid for both the first as well as second-generation technologies. When considering gaseous options, biomethane should be preferred for convenient energy balance in the productive process and when biogas cannot be directly employed. Moreover, biomethane gives the possibility to be added to the existing gas network. The new third and fourth-generation technologies could allow a considerable efficiency increase while reducing the problem of the biofuel productive chain.
Endogenous Ouabain in Human and Animal Models of Hypoxia
Authors: Manfrini Valerio , Poscia Roberto , Messaggio Elisabetta , Proietti Sara , Palumbo Sara , Fiorucci Letizia , Grande Francesco , Biancani Barbara , Pussini Nicola , Mastorci Francesca , Passera Mirko , Profico Antonio , Mariotti Veronica , Fanfani Alberto , Gemignani Angelo , Pellegrini Silvia , Manunta Paolo , Gili Claudia
Published: March 2022

Endogenous ouabain (EO) is a steroid hormone secreted by the adrenal glands, usually associated with adverse cardiovascular effects. However, recent studies have highlighted its possible role in blood pressure control and in cardio-renal damage, and it seems to be involved in the adaptive response to hypoxia. The aim of this study is to detect the EO in human and animal models of hypoxia. We collected blood samples from seven competitive elite apnea divers, 11 noncompetitive elite apnea divers, and 26 healthy control subjects. Animal blood samples were collected from 16 common bottlenose dolphins (Tursiops truncatus), two phocids and two otariids kept under human care, and 11 wild loggerhead sea turtles (Caretta caretta) hosted in two rescue centers. We measured EO plasma concentrations with a Scintillation Proximity Assay. In elite apnea divers and healthy control subjects, EO plasma concentrations were positively correlated to weight (p < 0.05). Elite apnea divers showed statistically significant (p < 10-6) higher EO plasma concentrations compared to healthy subjects without any diving experience or experience in other sports activities involving breath-holding. In dolphins, EO plasma concentrations were positively correlated to age, total length, and weight (p < 0.05). In loggerhead sea turtles, EO plasma concentrations were negatively correlated to total length and weight (p < 0.05). In pinnipeds, correlation analysis was not performed due to the small number of animals. Herein, we demonstrate, for the first time, that different taxa, phylogenetically distant from each other and which perform apneas without reporting neurological damages, express EO. Our findings, although preliminary, are in line with the recently emerging hypothesis on a possible role of EO in the adaptive response to hypoxia and represent a helpful hint for future investigations aimed to identify novel molecules useful to treat very disabling pathological conditions such as idiopathic pulmonary arterial hypertension or obstructive sleep apnea.
Behavioral Responses of a Harbor Porpoise (Phocoena phocoena) Depend on the Frequency Content of Pile-Driving Sounds
Authors: Kastelein Ronald A. , de Jong Christ A. F. , Tougaard Jakob , Helder-Hoek Lean , Defillet Linde N.
Published: March 2022

The loud, impulsive, broadband underwater sounds produced during offshore pile driving are known to have auditory and behavioral effects on harbor porpoises (Phocoena phocoena) in the areas around piling sites. Thresholds to prevent behavioral effects have not yet been set, and it is unclear whether or not auditory frequency weighting of piling sounds, as used for criteria to protect hearing (Southall et al., 2019), is also useful for predicting behavioral responses and therefore required to set safety criteria and develop mitigation measures. A harbor porpoise in a pool was exposed to playbacks of piling sounds, and her behavioral responses were quantified in comparison to baseline periods without piling sounds. The full-spectrum playback piling sound was recorded at 100 m from a piling site for an offshore wind turbine. For comparison, five low-pass filtered (6.3, 3.2, 1.5, 1.0, and 0.5 kHz) versions of the sound in which the bandwidth decreased were played back at the same duty cycle (46 strikes/min) and similar single-strike sound exposure levels (power average in the pool: 135 dB re 1 µPa²s; t90: 90 to 100 ms). As the bandwidth of the piling sounds decreased, the porpoise’s behavioral response became weaker. Although these results are based on only one porpoise, they indicate that harbor porpoises respond most strongly to the higher frequencies in piling sounds. Therefore, frequency weighting of the sound exposure level (SEL) will improve prediction of behavioral responses, and behavioral response threshold levels for criteria should also be expressed as weighted SELs. However, it is unclear whether the weighting for predicting auditory effects is also the best weighting to predict behavioral effects. Mitigation of the effects of piling sounds on harbor porpoise behavior should be focused on reducing the high-frequency part of the spectrum.
Surgical treatment of acute pancreatitis
Authors: Firsova V. G. , Parshikov V. V. , Kukosh M. V. , Gorskiy V. A.
Published: March 2022

The paper presents an analysis of the recent studies on the various aspects of surgical management of acute (excluding biliary) pancreatitis. It evaluates the suggestion of interventions in the sterile phase, which are limited to and include enzymatic peritonitis and abdominal compartment syndrome. Surgery is suggested when conservative treatment is ineffective, pain is present, which is associated with pancreatic fluid accumulation, there is a risk of the pancreatic fluid leaking into the abdominal cavity, or compression of the adjacent organs develops due to the disconnected pancre-atic duct syndrome. Infected necrosis is the main indication for surgical intervention in acute pancreatitis. The drainage is preferably delayed for at least 4 weeks following the onset of the disease, and is gradually performed (in a “step-up” manner). The choice of drainage technique is based on the necrosis localization, delimiting wall, surgeon’s expertise, and technical capabilities. Sequestrectomy can be performed starting from mini-invasive percutaneous drainage under endoscopic guidance, or using a covered metal stent. In the cases of early infection or advanced injury of retroperitoneal tissue, it is advisable to combine percutaneous and endoscopic methods, and use multiple transluminal gateway techniques with several draining tracts installed from single or multiple points of access.
Prediction and prevention of severe complications following radical surgical treatment of hilar cholangiocarcinoma
Authors: Zamanov E. N. , Efanov M. G.
Published: March 2022

This literature review highlights the recent advances in the prevention and prognosis of purulent-septic complications, post-resection liver failure, and other severe postoperative complications following the surgical treatment of hilar cholangiocarcinoma. The data obtained from the analysis of the recent scientific publications indicate the relevance of this problem. Research should be prioritized to formulate combined methods that can assess the risk of perioperative complications.
Minimally invasive treatment of hepatic hydatid cysts complicated by the rupture into the biliary tract
Authors: Kirtanasov I. P. , Andreev A. V. , Durleshter V. M. , Gabriel S. A. , Izmailova L. G.
Published: March 2022

The paper presents the clinical observations of the rare complication of hepatic hydatid disease: the rupture of hydatide cysts into the bile ducts. The complication causes obstruction of the bile ducts, obstructive jaundice, and cholangitis. The basic stages of diagnosis and the role of ultrasound in detecting the complications of hepatic hydatid disease have been highlighted in this paper. The minimally invasive percutaneous and endoscopic techniques under radiological guidance have been reviewed.
[RETRACTED] Clinical CBD Gummies Reviews - Fake Or Real? v1
Authors: CBD Gummies Smilz
Published: March 2022

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Clinical CBD Gummies Reviews - Fake Or Real?
[RETRACTED] Goodness Keto Gummies Shark tank reviews v1
Authors: not provided goodnessgummiesreviews
Published: March 2022

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Goodness Keto Gummies Shark tank reviews
[RETRACTED] Doctor G's Best Brain Cognitive Support Reviews :- Doctor G’s Best Brain Formula! v1
Authors: G's Best Brain Cognitive Support Doctor
Published: March 2022

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Doctor G's Best Brain Cognitive Support Reviews :- Doctor G’s Best Brain Formula!
[RETRACTED] Apple Keto Gummies Australia - Shark Tank v1
Authors: not provided Appleketogummyaustralia
Published: March 2022

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Apple Keto Gummies Australia - Shark Tank
[RETRACTED] Doctor G's Best Brain Cognitive Support Reviews: Real or Hoax Price of Best Brain Cognitive Support Pills? v1
Authors: G's Best Brain Cognitive Support Doctor
Published: March 2022

[RETRACTED]

Doctor G's Best Brain Cognitive Support Reviews: Real or Hoax Price of Best Brain Cognitive Support Pills?
[RETRACTED] Eagle Hemp CBD Gummies Review Pure CBD Gummies Safe, Non-Habit Forming, Effective And 100% legal v1
Authors: not provided Williehduffie
Published: March 2022

[RETRACTED]

If you are among those people suffering from chronic illnesses such as anxiety, depression, joint pain, insomnia and more, then it is a good time to start using gummy buffs full CBD balls. However, please keep in mind that not all gummy bears on the market are supported by pure CBD oil extraction. Therefore, you should solve a suitable CBD gummy like Eagle Hemp CBD Gummies. This is a fully-fledged gummy bear made from edible CBD oils found in the body of hemp plant leaves. As physically built gummy does not cause any side effects. It virtually enhances all aspects of the ECS system in the body to control maximum performance and improve your internal and external health naturally.
Autoimmune thyroiditis in different age groups and subjects of reproductive age in Adzhariya population
Authors: Tchelidze N. G. , Glonti S. Z. , Baratashvili D. Sh. , Kedelidze N. O. , Ungiadze J. Yu. , Nakashidze I. I.
Published: March 2022

Introduction. Autoimmune thyroiditis (AIT) is the most prevalent among the autoimmune pathologies and multifactorial thyroid diseases; accordingly, remaining a pressing issue for investigation.

Aim: to study AIT profile in different age groups of the female population in the western region of Georgia – Adzhariya.

Materials and Methods. A prospective comparative study in parallel groups was carried out. There were examined 405 samples of venous blood obtained at «Health» Clinic from women of two groups: group 1 – 159 patients with AIT, group 2 (control) – 246 women without AIT. Blood samples were collected between the years 2017 and 2020. There were analyzed serum antibodies against thyroperoxidase (TPOAb), thyroid stimulating hormone (TSH) as well as level of free thyroxine (FT4) by using enzyme immunoassay.

Results. Patients with AIT from different age groups vs. control group were found to have decreased level of FT4, but increased amount of TSH and TPOAb. At the reproductive age (18–45 years), a significant increase in the level of TSH was found (6.12 times) compared with the control group (p < 0.0001). The level of FT4 and TSH in AIT women aged 51 to 60 years was 0.7880 ± 0.3584 ng/ml and 4.754 ± 2.433 U/ml that significantly differed from those in the control group – 1.314 ± 0.4044 ng/ml (p < 0.0001) and 2.276 ± 1.409 U/ml (p < 0.0001), respectively.

Conclusion. AIT occurs in women of all age groups, but is more common in women aged 51 to 60 years. In a number of cases, TPOAb was detected in the control group, which, apparently, is associated with increased intake of dietary iodized salt since 2005 in Georgia (the adoption of the law on universal salt iodization). A significant increase in the level of TSH, in AIT women aged 18–45 years, strongly suggests to perform diagnostics of and screening for AIT not only in females of menopausal period, but also in reproductive age.
Placenta crucially affects formation of fetal congenital heart disease
Authors: Tsibizova V. I. , Pervunina T. M. , Artemenko V. A. , Bitsadze V. O. , Gotsiridze K. E. , Averkin I. I. , Blinov D. V. , Novikova N. Yu.
Published: March 2022

It has been increasingly recognized that structural abnormalities and functional changes in the placenta can adversely affect developing fetal heart. In this article, we examine a role of the placenta as well as potential impact of placental insufficiency on a fetus with congenital heart disease (CHD). The fetal heart and placenta are directly connected because they develop simultaneously with common regulatory and signaling pathways. Moreover, placenta-associated complications are more common in pregnant women carrying fetus with CHD, and the fetal response to placental insufficiency may lead to postnatal preservation of remodeled heart. The mechanisms underlying this placenta–fetus axis potentially consists of genetic factors, oxidative stress, chronic hypoxia, and/or angiogenic imbalance. Thus, the mother–placenta–fetus circulation is critical in understanding the CHD formation. It is necessary to study the changing factors involved in these processes for early identification, imaging, quantification of placental insufficiency, and development of new prenatal therapies in the CHD patient population.
Thrombosis risk and in vitro fertilization
Authors: Grandone E.
Published: March 2022

Assisted reproductive technologies (ART) have been progressively recognized as a widely applied means to fight against infertility. Women after ART were shown to have higher risk of developing venous thromboembolism (VTE) that might be related to using some drugs, particularly gonadotropins. VTE risk emerges at relatively early time points after ovulation induction being sustained virtually until pregnancy is complete. According to the multi-center RIETE Registry (Spanish, Registro Informatizado de la Enfermedad TromboEmbolica), a risk of developing isolated pulmonary embolism (PE) is elevated in women after ART compared to those receiving hormonal contraceptives as well as women having spontaneous pregnancy. Low-molecular-weight heparins (LMWH) are justified to be used as a preventive means. However, commonly recommended preventive LMWH dose in such patient cohort may not always be sufficient. On the other hand, escalating dose for some LMWH results in increased rate of developing hemorrhages. Hence, it is important to take into consideration what exact type of LMWH as well as its dose and duration of therapy should be prescribed to women after ART that requires to be further investigated.
NÖROPAZARLAMA YAKLAŞIMLARINI SIGMUND FREUD’UN YAPISAL ZİHİN MODELİ ÇERÇEVESİNDE DEĞERLENDİRMEK
Authors: Gökgül Ahmet Neca
Published: March 2022

Nöropazarlama alanında araştırma yapan uzmanlar, nörobilim alanında kullanılan çeşitli teknikler vasıtasıyla pazarlama alanının sorunlarına yönelik yeni çözümler bulmaya çalışmaktadır. Nöropazarlamacı olarak da ifade edilen uzmanlar, nörogörüntüleme teknikleriyle insan beyninin tepkilerini ölçerek elde ettikleri bilgileri, pazarlama kararları alırken kullanmaktadır. Nöropazarlama alanında yapılan çalışmalar sonucunda, insan zihni çeşitli yapısal kategorilere ayrılarak incelenmekte, bu alanda başarılı olmanın yolunun beynin yapılarının anlaşılması ile doğrudan ilişkili olduğu belirtilmektedir. Beynin yapılarının anlaşılmasını sağlayacak temel çalışmalar, nörobilim literatüründe yer almakta, fakat nöropazarlama alanında bu konu ile ilgili yeterli çalışma bulunmamaktadır. Bu çalışmanın amacı beynin nasıl çalıştığı ile ilgili yapılan nörobilim çalışmalarını, nöropazarlama bakış açısı ile incelemek ve nörobilim literatürüne katkı sunacak unsurları keşfetmektir. Keşfedici araştırma yöntemiyle gerçekleştirilen çalışmada, beynin bilinmez süreçleri ile ilgili araştırmaların temelini atan Sigmund Freud’un bilinç ve bilinçaltını içeren topografik zihin modeli ile id, ego ve süperegoyu içeren yapısal zihin modelinin nöropazarlama yaklaşımları açısından son derece önemli olduğu tespit edilmiştir. Söz konusu tespitten hareketle, Freud’un yapısal zihin modelinin nöropazarlama çalışmalarını açıklamada önemli bir kavram olduğu ortaya konulmakta ve değerlendirilen konu üzerine çeşitli öneriler getirilmektedir.
A randomized, double-blind, parallel, placebo-controlled study to evaluate efficacy and safety of a synergistic multi-herbal extract blend KaraHeart™ in supporting healthy cholesterol levels
Authors: Rajendran Krishna , Ramaswamy Rajendran , L. Sucharitha , Rajendran Ravikumar , Bharadwaja Ramachandra , K. Latha , Deep Dheeraj Kumar
Published: March 2022

Background: Hyperlipidemia is a condition involving abnormally high levels of lipids in the blood. Hyperlipidemia is a major risk factor for cardiovascular diseases and refers to either high levels of triglycerides (TGL) or cholesterol. Herbal supplements have been used in the management of cholesterol levels in Ayurveda, a complete medical system originating in India. KaraHeart™ is a multi-herbal extract synergistic blend that may help in the management of healthy cholesterol levels. The current study tested the efficacy, tolerability, and safety of KaraHeart™ versus a placebo in the management of cholesterol levels of patients with mild hyperlipidemia.Methods: This was a randomized, double-blind, parallel, and placebo-controlled study. A total of 100 patients were divided into two groups. One group was given KaraHeart™ and the other group was given a placebo for 120 days. Treatment results were assessed by checking the lipid profile parameters such as total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and TGL.Results: The study found that the herbal supplement KaraHeart™ significantly reduced levels of LDL, VLDL, TGL, and total cholesterol, while increasing the levels of HDL in the blood. Additionally, the study concluded that KaraHeart™ was safe to use.Conclusions: KaraHeart™ was shown to be safe and effective in the management of cholesterol levels.
Estimates of genetic gains in the carrot using different selection indices
Authors: Carvalho Agnaldo Ferreira , Pereira Gabriel Emiliano , Da Silva Giovani Olegário
Published: March 2022

The carrot is one of the most important and preferred vegetables in Brazil due to its versatility and nutritional significance, especially as a source of vitamins. The selection of carrot genotypes should consider several agronomically important characteristics to allow more suitable and balanced gains. The aim of the present study was to estimate genetic gains in the carrot using different selection indices. Thirty-six carrot genotypes were evaluated in two experiments, the first conducted between 16 November 2017 and 1 March 2018, and the second between 5 March and 18 June 2018 in, Brasilia. In both trials. the experimental design was of randomised blocks with three replications. The plots were sown directly onto the seedbed, which had a total working area of 1.8 m2. The incidence of leaf blight was evaluated 78 to 98 days after sowing, at intervals of seven days, giving a total of four evaluations. The harvest was carried out at 105 days when the characteristics of the yield components were measured. An analysis of variance was applied, together with five selection indices: direct selection, classic, desired gain, weight- and parameter-free, and genotype-ideotype. There were differences between genotypes for most of the characteristics under evaluation. The genotype-ideotype index afforded the greatest gains for the characteristics being evaluated, with an economic weight equal to the coefficients of genetic variation; however other indices were also efficient and offered balanced gains, with the exception of the desired-gain index.
What Causes Differences in PM2.5 Concentration in China? Structures are more Important
Authors: Jia Chengye , Huang Weige
Published: March 2022

This paper studies the effects of factors such as economic growth, industrial structure and governance on the differences in PM2.5 concentration among groups by using Oaxaca-Blinder (OB) decomposition and Recentered Influence Function (RIF) regressions. Specifically, we first explore the differences in PM2.5 concentration among cities and find that structure effects attributable to differences in returns to these factors contribute more to total difference in PM2.5 concentration than composition effects caused by differences in the means of these factors. Moreover, the offsetting effects of positive composition and negative structure effects drag the time trend of PM2.5 concentration downward. Besides, the negative impact of GDP per capita on PM2.5 concentration implies the existence of an inverted U-shaped environmental Kuznets curve (EKC) between PM2.5 concentration and GDP per capita. In sum, we find that the differences in returns to factors or structures of cities are the main causes of differences in PM2.5 concentration among cities in China compared to the differences in the means of factors.
Diet reconstruction of the Sarmatians at Madaras. A preliminary survey
Authors: Smrčka Vάclav , Jambor Jaroslav , Marcsik A.
Published: March 2022

117 samples from the proximal femora were taken from 50 skeletons excavated from the Sarmatian cemetery at Madaras, situated on the southern part of the Hungarian Plain between the Danube and Tisza rivers. These skeletons date from the 3rd to the 5th century A.D. A trace element analysis was used in order to reconstruct their basic diet. The primary part of the Sarmatians' diet was vegetable as Sr, levels were high whereas the Zn levels were low. Low Pb concentrations in the. Sarmatians' bones, as compared to those of surrounding populations, testify to the low Pb of those surrounding populations, testify to the low Pb contamination in their diet.