bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing the performance, carcass characteristics, diet digestibility, and economic viability of pigs in the growing and finishing phases through aspartic protease supplementation: a comprehensive evaluation
Authors: Cruz Thiago Augusto , Muro Bruno Bracco Donatelli , Lima Eduardo Machado Costa , Moreira Valeria dos Santos , Carvalho Julio Cesar Carrera , Garbossa Cesar Augusto Pospissil , Costa Leandro Batista
Published: October 2023

The objective of this study was to evaluate the performance, carcass characteristics, diet digestibility, blood parameters, salivary cortisol levels, and economic viability of pigs administered aspartic protease during the growing and finishing phases. A total of 130 pigs (age, 63 days ± 1; and average weight, 25.56 ± 0.037 kg) were housed in pens in a randomized block design (initial weight and gender). Five treatment protocols were developed and nine replications per treatment were performed. The experimental diets were positive control (PC), according to the recommendations of Rostagno et al. (2017), with a 5.0% reduction in protein and amino acid requirements; negative control (NC), according to the recommendations of Rostagno et al. (2017), with a 7.5% reduction in protein and amino acid requirements; NC + 100 g/ton of aspartic protease (NC100); NC + 150 g/ton of Aspartic protease (NC150); and NC + 200 g/ton of another protease (NC200). The inclusion of protease, independent of the source and amount, increased the daily weight gain (P < 0.05) of animals compared to treatment with the controls, improved feed conversion (P < 0.05) in some phases, and improved diet digestibility (P < 0.05) compared to the PC. Treatment with NC150 and NC200 resulted in greater carcass weights than treatment with the PC. NC100 led to a greater carcass yield than PC, and NC150 resulted in a greater loin eye area than PC. No differences (P > 0.05) in the blood parameters or salivary cortisol levels were found among the treatment groups. Regarding economic viability, the use of protease increased the profitability of production, with NC150 leading to the best results. Thus, the use of aspartic proteases is recommended to improve performance and effectively facilitate pork production.
Analysis of Bilingual Text in Pakistani Advertisements: A Sociolinguistics Study
Authors: Nusrat Muhammad , Ghulam Kishwar
Published: October 2023

This study based on sociolinguistics aspects on advertisements and these advertisements containing bilingual text and diversity of human life governed through advertisements in which all cultural life portrayed by advertisers and designer of these companies design the advertisements according to regional culture as this research based on the bilingual text on Pakistani advertisements and according to Pakistani culture the most common used language is URDU which analyzed in this research along with commonly used international language ENGLISH. This study revealed that linguistics and semiotics on advertisements according to Pakistani culture and this research is based on the qualitative design which explored cross-cultural aspects based on Roland Barthes’s theory. These ads become a source of target audiences of that culture and bilingual text on advertisements became the source of the conversation thus promoting products, and constructing identity in this diversity occurred through bilingual advertisements like Banks, companies’ identity, beauty products, food and clothing brands, medicine companies remained the research study.
Guide for Aquifer Recharge Through Deep Injection Wells in Karst Environments: Case Study Los Elizondo Gallery, Mexico
Authors: ahuja gerardo augusto montemayor
Published: October 2023

The challenges posed by the various factors that affect the loss of surface and underground aquifers worldwide, specifically in Mexico, are increasingly severe. This has forced scientists and technicians to look for alternatives to conserve, sustain, and ensure the sustainability of liquid deposits, whether surface or underground in nature. Based on the above, it was proposed to evaluate the technical and technological feasibility of constructing a well for the artificial injection of water into the subsoil in the Los Elizondo Gallery in the Huajuco area. The objective was to provide a technical and technological guide for the planning, design, and development of groundwater conservation by deep injection. The methodology corresponded to a feasible project, in which the procedures for the construction of the artificial water injection well to underground causes were followed. The technical and technological feasibility of the construction of the well was evaluated, including the examination of the geological and hydrological conditions of the area, as well as the available technologies and materials that can be used to build the well. The execution of the project led to the determination that the construction of a well for the artificial injection of water into the subsoil is technically and technologically feasible in the area of the Los Elizondo Gallery. Once the appropriate procedures were applied, the Guide for aquifer recharge through deep injection wells in karst environments was developed: a case study Los Elizondo Gallery, Mexico.
Enabling biocontained plant virus transmission studies through establishment of axenic whitefly (Bemisia tabaci) colony on plant tissue culture
Authors: Thompson Natalie , Krum David , Chen Yun-Ru , Torres Mariela , Trauger Marena , Strike Dalton , Weston Zachary , Polston Jane , Curtis Wayne
Published: October 2023

A colony of axenic ‘sweet potato’ whiteflies (i.e., free from culturable microorganisms) was established on tissue-cultured plants and was used to demonstrate in vitro begomovirus transmission. A co-culture system based on non-viral host cabbage (Brassica oleracea) provides for efficient maintenance of a whitefly (Bemisia tabaci) colony. The recovery of emerging whiteflies through coupled tissue culture vessels to new axenic plants allows robust subculturing and facilitates the production of hundreds of whitefly adults per month in a 1.1 L tissue culture vessel. This novel ‘communal axenic’ plant-insect-virus (aP-I-V) protocol provides high-level biocontainment to allow for work with genetically modified viruses. Versatility is illustrated by achieving whitefly proliferation on more than a dozen plant species as well as methods for in vitro testing of whitefly preference for different plants – although there were large differences in whitefly accumulation and ease of host use. Although initial colony establishment was achieved with surface sterilization of detached whitefly eggs on vegetatively propagated sweet potato (Ipomoea batatas), a much more reliable approach is described based on non-axenic whitefly egg-lay onto axenic phototrophically tissue-cultured plants, followed by surface sterilization of the pedicel-attached eggs. Axenic whitefly adults were able to acquire and transmit tomato mottle virus (ToMoV) (Genus: begomovirus) from Nicotiana benthamiana tissue cultured material. This indicated the absence of a role for culturable gut microorganisms in the transmission of this begomovirus. Acquisition occurred from tissue-cultured plants initially inoculated with ToMoV via Agrobacterium infective clones as well as from a gamma irradiated sachet of parafilm. An autoclavable membrane device was developed to facilitate a simpler approach to undertake virus transmission in biocontained, axenic plant tissue culture. The methodology described here could be used to address a wide range of questions regarding whitefly feeding on plants as well as their transmission of viruses without the expense, facilities, and contamination risks associated with standard approaches.
Multi-source data fusion strategy for the discrimination of Succus Bambusae oral liquid from different manufacturers
Authors: Ying Zehua , Zhang Zhiyong , Feng Huimin , Guo Shubo , Qiu Ping , Li Wenlong
Published: October 2023

This study aims at developing an extensive strategy for distinguishing Succus Bambusae oral liquid (SBOL) from different manufacturers. First, a combination of HS-GC-IMS and Ultra-fast GC E-nose method was established to perform a qualitative analysis of volatile compounds in SBOL. Second, in combination with the results of previous GC-MS studies, a multi-source data fusion strategy based on three signal sources distinguishes SBOL samples from various manufacturers. Multi-level data fusion strategies, including low-level data fusion, mid-level data fusion, and high-level data fusion which were evaluated and compared revealing their advantages and disadvantages in the classification context. The results suggest that the mid-level-SV data fusion strategy exhibits superior discrimination performance, thereby being chosen as the best data fusion strategy. Overall, this study provides a more comprehensive characterization of chemical information of SBOL samples, facilitating the improvement of SBOL quality standards and offering scientific insights and a foundation for the regulation of the SBOL market.
A Cross-Sectional Study to Assess the Financial Hardships of Rural Households with Special Reference to COVID-19
Authors: Panchgaur Richa , Verma Ashish Kumar , Kumar Alok
Published: October 2023

The COVID-19 epidemic had an impact on the economic well-being of rural households, forcing them to adopt a new survival strategy. The Government of India also introduced several relief programmes to help the common people who were struggling financially as a result of the lockdown during the epidemic. The main objective of this paper is to assess the access of rural households to economic relief schemes and also the economic condition of rural households during the COVID-19 epidemic. The paper is based on a survey of 300 households in 30 villages of district Varanasi, Uttar Pradesh, India. We found a significant relationship between access to free ration and social category (χ2 = 7.27, p < 0.05) and to the level of education of the head of the household (χ2 = 15.94, p = 0.01). We also found that Scheduled Castes and Scheduled Tribes households experienced lack of ration or daily necessities ten times more than households of general category during the COVID-19 epidemic. Similarly, households of Other Backward Classes experienced lack of ration four times more than households of General category. There was substantial impact of COVID-19 epidemic on the financial status of rural households.
Quantitative errors in the Cochrane review on "Physical interventions to interrupt or reduce the spread of respiratory viruses"
Authors: Bar-Yam Yaneer , Samet Jon , Siegenfeld Alexander , Taleb Nassim
Published: October 2023

The COVID-19 pandemic has brought a heightened sense of urgency in the scientific community regarding the need to advance understanding and prevention of pathogen transmission, particularly concerning infectious airborne particles and the utility of various preventive strategies in reducing the risk of infection. There are extensive studies validating scientific understanding about the behavior of larger (droplets) and smaller (aerosols) particles in disease transmission and the dosimetry of particles in the respiratory track. Similarly, modalities for respiratory protection against particles in the size range spanned by infectious particles, such as N95 respirators, are available and known to be efficacious with tested standards for harm reduction across environments including physical, chemical and biological hazards. Even though multiple studies also confirm their protective effect when adopted in healthcare and public settings for infection prevention, overall, studies of protocols of their adoption over the last several decades in both clinical trials and observational studies have not provided as clear an understanding. Here we demonstrate that these studies are strongly biased towards the null by infections resulting from transmission outside of the investigated environments and study participants. Such study limitations are frequently mis-stated as not influencing the conclusions of research on respiratory protection. The reason for the failure to properly analyze the studies is that the standard analytical equations used do not correctly represent the random variables that play a role in the study results. By correcting the mathematical representation and the equations that result from them, we demonstrate that conclusions drawn from these studies are strongly biased and much more uncertain than is acknowledged, providing almost no useful information. Even with all these limitations, we show that existing results, when outcome measures are properly analyzed, consistently point to the benefit of precautionary measures such as N95 respirators over medical masks, and masking over its absence. We also show that correcting manifest errors of widely reported meta-analyses also leads to statistically significant estimates. Our results have implications for the design of studies and analyses on the effectiveness of respiratory protection and on using existing evidence for policy guidelines for infection control.
An Online Ensemble Method for Auto-scaling NFV-based Applications in the Edge
Authors: Silva Thiago Pereira da , Batista Thais Vasconcelos , Delicato Flavia C. , Pires Paulo F.
Published: October 2023

The synergy of edge computing and Machine Learning (ML) holds immense potential for revolutionizing Internet of Things (IoT) applications, particularly in scenarios characterized by high-speed, continuous data generation. Offline ML algorithms are unsuitable for data streams, as they require existing datasets to build prediction models. As an embodiment of ML, which embraces the fact that learning environments change over time, in Online Machine Learning (OML) the model is trained with each new observation in production time. Most OML algorithms are developed after the offline version and present different behaviors, considering bias and variance. Finding a suitable estimator to solve a ML problem is still a challenge. In this context, ensemble learning emerges as a promising approach for balancing the bias-variance tradeoff and improving prediction accuracy by aggregating outputs from multiple ML models. This paper introduces a novel ensemble method tailored for edge computing environments, designed to efficiently operate on resource-constrained devices while accommodating various online learning scenarios. The primary objective is to enhance predictive accuracy at the edge. We conducted extensive experimental evaluations to assess our proposed ensemble's predictive performance using synthetic and real datasets. Our ensemble outperformed state-of-the-art data stream algorithms and ensemble regressors across various regression metrics. Furthermore, we evaluated the ensemble's performance in the context of auto-scaling for Virtual Network Function (VNF)-based applications operating at the network's edge.
Effect of Students’ Activities on Academic Performance Using Clustering Evolution Analysis
Authors: Setiabudi Djoni Haryadi , Santoso Michael
Published: October 2023

Educational data mining is a technique to evaluate educational process of university students, especially in their early stages. Most preliminary studies focus on observing courses undertaken by students from one semester to the next to predict their success rate. However, besides studying, many students are also involved in non-academic activities, which tends to affect their grades. Therefore, the research aims to determine the effect of student activities on grades while taking into account their academic activities. The method used for clustering is K-Means. Data are collected by observing students’ activity patterns in lectures. The research is conducted in two study programs at Petra Christian University: Business Management and Architecture. The results show that the K-Means method gives good results. The clusters formed from the data show non-homogenous groups and produce insights from several groups. The results show a tendency for students’ performance to increase along with the number of activities and points earned. Most students have increased activities during busy times in the third, fourth, fifth, and sixth semesters. The peak is between the fifth and sixth semesters. Then, it starts to decrease in the seventh and eighth semesters. Therefore, students’ activities in the Business Management study program affect performance significantly. Meanwhile, in the Architecture study program, it has an insignificant effect on performance.
O USO DAS FERRAMENTAS DA ANÁLISE DA SUPERFÍCIE DE HIRSHFELD NO ESTUDO DAS LIGAÇÕES NÃO-COVALENTES EM COMPLEXOS CORRELATOS
Authors: Iwaya Eduardo , Miorim Avany , Reis Dayane
Published: October 2023

THE USE OF HIRSHFELD SURFACE ANALYSIS TOOLS IN THE STUDY OF NON-COVALENT BONDS IN RELATED COMPLEXES. The analysis of non-covalent interactions in crystalline structures through the Hirshfeld surface method using the CrystalExplorer® software has been widely used by the global scientific community over the past few decades. Although widely recognized, as far as we know, there has been no publication on this subject in the Química Nova journal. Therefore, in this work, we intended to demonstrate how these tools could be employed to study and compare the non-covalent bonds in 21 mononuclear complexes of the type [MY2(o-XPy)2], [MY2(m-XPy)2], and [MY2(p-XPy)2], where M = Zn2+ or Co2+, Y = Cl-, Br-, or I-; Py = pyridinic ligand ortho-, meta-, or para-monosubstituted by X, where X = Cl-, Br-, or I-. With a main emphasis on halogen bonds and π···π stacking interactions, the study demonstrates how Hirshfeld analysis can be used for a qualitative and quantitative comparison of non-covalent bonds, proving to be an important tool for a comprehensive understanding of the forces that stabilize these complexes in the solid-state. The study demonstrates the potential of Hirshfeld surface analysis as a valuable resource for synthetic chemists to select chemical species for rational synthesis and achieve desired properties or supramolecular arrays.
Kemampuan Memahami Rukun Islam Anak : Pengaruh Video Kompilasi “Diva Series”
Authors: Zahro' Harisatuz , Mas’udah Mas’udah , Reza Muhammad , Khotimah Nurul
Published: October 2023

This study aims to determine the effect of video in increasing the ability to understand the Pillars of Islam in children. The subjects in this study totaled 22 children consisting of 11 children in the experimental group and 11 children in the control group. This study used a quantitative research approach with a quasi-experimental research design and a non-equivalent control group design using two groups, namely the experimental group and the control group. The data collection technique uses observation and documentation using the data analysis technique Mann-Whitney U test. The results of data analysis obtained from the calculation of the Mann-Whitney U-Test using IBM SPSS Statistics 26 get the Asymp.Sig value. (2 tailed) which is equal to .000. On the basis of decision making when Asymp.Sig. 0.05, there is a significant difference between the experimental group and the control group, in which the value of the experimental group is higher than the value of the control group, so that Ha is accepted and Ho is rejected. The results of the study can be concluded that the Diva series compilation video has a significant influence on the ability to understand the Pillars of Islam in children. This was reinforced by the results of descriptive statistics in the experimental group which showed an increase in the ability to understand the pillars of Islam by 62, these results differed greatly from the control group, which was 22.
Pengaruh Pola Asuh Orang Tua Terhadap Munculnya Permasalahan Perilaku Sosial Emosional Anak Usia Dini
Authors: Nur Aini Lathifatun
Published: October 2023

Perkembangan sosial-emosional anak usia dini merupakan kemampuan anak untuk sepenuhnya mengelola dan mengekspresikan emosi baik positif maupun negatif. Fokus permasalahan yaitu bagaimana bentuk pola asuh orang tua serta karakteristik perilaku sosial emosional anak di Desa Degan. Jenis penelitian ini yaitu penelitian lapangan (fiels research) dengan pendekatan kualitatif. Pengumpulan data penelitian menggunakan observasi, wawancara, dan dokumentasi. Analisis data menggunakan metode deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa pola asuh yang diterapkan oleh Ibu Nia adalah pola asuh demokratis semi otoriter, Ibu Siti pola asuh otoriter, Ibu Lia dan Ibu Gita pola asuh permisif. Perilaku sosial emosional Amir dengan pola asuh demokratis semi otoriter antara lain: disiplin, memiliki kesadaran berbagi, kerja sama, tolong menolong, mengerti tugas dan tanggung jawab, agresif, mandiri, antusias dalam belajar, sulit diatur, berkata kasar, pemalu, mudah marah, ketika menginginkan sesuatu harus dituruti, dan mudah menangis. Sedangkan Fika dengan pola asuh otoriter memiliki perilaku sosial emosional antara lain: agresif tapi pasif, mandiri, kritis, kesadaran berbagi dan tolong menolong, kurang antusias dalam belajar, mudah marah, mau menang sendiri, dan pemalu. Perilaku sosial emosional Riski dengan pola asuh permisif antara lain: hyperaktif, sulit diatur, agresif, kurang antusias dalam belajar, percaya diri, tidak disiplin, mudah marah, emosi tidak stabil, manja. Sedangkan perilaku sosial emosional Kevin antara lain: agresif, sulit diatur, percaya diri, mudah bergaul, mandiri, kesadaran tolong menolong, kurang antusias dalam belajar, kurang disiplin, mudah marah, mudah menangis, serta emosi yang tidak stabil.
Endophytic Fungi: A Natural Source of Bioactive Compounds and Biotechnological Applications
Authors: Coertjens Nicole Carneiro , Mascarenhas Maria do Socorro , Batiatote Margareth
Published: October 2023

Endophytic fungi are microorganisms that live inside plants and are a promising source of bioactive molecules. These fungi have aroused a growing interest in research due to their ability to produce a variety of substances. Thus, this study aims to emphasize the relevance of endophytic fungi present in plants as a source of bioactive compounds, which have several applications in biotechnology. For this, scientometrics was used as a methodology, based on a search in the ScienceDirect database using the terms "endophytic fungi", "plants", "metabolites" and "biotechnological application" in a time frame between 2015 and 2022. These fungi have aroused a growing interest in research due to their ability to produce a variety of bioactive compounds. The interaction between endophytic fungi and plants is crucial for plant survival, and many of the compounds produced by fungi have biotechnological potential. Scientometrics revealed an increase in the number of publications on the subject, with emphasis on research studies and reviews. The prospection of endophytic fungi has focused on families of plants with medicinal attributes. These complex interactions between fungi and plants play an important role in plant health and development. Research in this area continues to grow, with many compounds identified as potential bioactive products in diverse biotechnological applications.
Las Obtenciones Vegetales en Colombia: Un Análisis Crítico desde sus Implicaciones Sociales y Ambientales
Authors: Vargas Chaves Iván , Guzmán-Aguilera Clara Lucía , Argüello-Rueda José Darío
Published: October 2023

El presente artículo tiene como objetivo plantear una crítica a la regulación de las obtenciones vegetales en Colombia; desde los intereses jurídicos tutelados en el ordenamiento vigente, la política alimentaria y desde la necesidad de generar una política de competitividad social y ambientalmente responsable. La metodología escogida es cualitativa, desde un enfoque de análisis documental sobre la información y los datos obtenidos en documentos de organismos nacionales e internacionales, doctrina, políticas públicas, jurisprudencia y normatividad en este ámbito. Como resultado, se presenta un escenario reflexivo, con una mirada desde las políticas y reglamentaciones internacionales, nacionales y locales, además de las nuevas corrientes postmodernas, en especial el Transhumanismo. El artículo concluye que es necesario redimensionar la regulación de las obtenciones vegetales, pues, además de no reportar utilidades a los agricultores y a la industria nacional en aras de un crecimiento interno sostenido, se generan impactos negativos al ambiente y la sociedad.
Diversidade de Microrganismos no Trato Intestinal e Resíduos Digestivos de Trigoniulus corallinus
Authors: Passos Samuel Ribeiro , Antunes Luiz Fernando de Sousa , Rumjanek Norma Gouvêa , Correia Maria Elizabeth Fernandes , Xavier Gustavo Ribeiro
Published: October 2023

O objetivo deste trabalho foi avaliar a comunidade microbiana associada ao trato intestinal do diplópode Trigoniulus corallinus. Os diplópodes foram coletados e incubados em dietas com serrapilheira de grama batatais (Paspalum notatum) e sabiá (Mimosa caesalpinifolia). A análise do gene 16S DNA por DGGE revelou diversidade microbiana condicionada pela dieta oferecida até os 45 dias. Após este período o efeito não foi mais visível. A comunidade associada aos coprólitos e ao tipo de serrapilheira distribui-se em agrupamentos separados das amostras oriundas do trato intestinal. O mesmo não foi observado na avaliação da comunidade de actinomicetos, onde o grande diferencial para divisão de grupos foi a dieta. Os animais alimentados com serrapilheira de grama mostraram uma comunidade diversa e não influenciada pelo tempo ou compartimentalização. As amostras associadas à serrapilheira e aos coprólitos foram 80% similares às do trato intestinal. Todas as amostragens tiveram genes nifH detectados via PCR. Há evidências de FBN no trato intestinal do diplópode. A comunidade de procariotos foi influenciada pela dieta oferecida até os 45 dias e a comunidade de actinomicetos foi condicionada em função da dieta.
Uma Revisão Bibliográfica acerca da Inserção de Fibras Naturais em Processos Alternativos na Indústria 4.0 Visando uma Produção mais Limpa
Authors: Duarte Eduarda Bertoletti , Rezende Luciana Cristina Soto Herek
Published: October 2023

No Brasil são geradas cerca de 225.965 toneladas de resíduos diariamente, apesar da Política Nacional dos Resíduos Sólidos (Lei Federal nº 12.305/2010) ter sido implementada em 2010, um número expressivo destes ainda são eliminados e dispostos de forma incorreta no ambiente, acarretando problemas e contaminações. Com isso, destacam-se as pesquisas com vistas à valorização destes subprodutos em processos alternativos que almejam uma produção mais limpa adequando-se à indústria 4.0. Deste modo, o presente artigo teve como objetivo a avaliação de fibras naturais na impressão 3D a partir de uma revisão sistemática no modelo PRISMA nas bases Scopus, Science Direct, Web of Science e Capes. A pesquisa resultou em 86, 751, 36 e 95 artigos, respectivamente, após os critérios de elegibilidade e exclusão de artigos não relacionados, foram incluídos 157 artigos neste trabalho. Na análise da correlação entre as citações dos artigos selecionados foi utilizado o software VOSviewer® na construção do mapa de Cluster. Observou-se um crescimento dos estudos sobre o tema ao longo dos anos, fato evidente acerca da manufatura aditiva. Em relação as fibras naturais mais utilizadas para impressão 3D, todas foram fibras vegetais, nas quais a composição majoritária se dá pela celulose. Na avaliação da contribuição científica por país, destaca-se uma maior participação da Índia, Estados Unidos e China, respectivamente. O Brasil, por sua vez, se encontrou consideravelmente atrasado. Dessa forma, pode-se avaliar que, mesmo com legislações acerca de resíduos, o país ainda tem uma geração e disposição incorreta significativa e os estudos sobre novas tecnologias ainda são muito escassos quando comparados a outros países.
Recent Developments and Applications of Biocatalytic and
Chemoenzymatic Synthesis for the Generation of Diverse Classes of Drugs
Authors: Verma Swati , Paliwal Sarvesh
Published: October 2023

Biocatalytic and chemoenzymatic biosynthesis are powerful methods of organic
chemistry that use enzymes to execute selective reactions and allow the efficient production of
organic compounds. The advantages of these approaches include high selectivity, mild reaction
conditions, and the ability to work with complex substrates. The utilization of chemoenzymatic
techniques for the synthesis of complicated compounds has lately increased dramatically in the
area of organic chemistry. Biocatalytic technologies and modern synthetic methods are utilized
synergistically in a multi-step approach to a target molecule under this paradigm. Chemoenzymatic techniques are promising for simplifying access to essential bioactive compounds because of the remarkable regio- and stereoselectivity of enzymatic transformations and the reaction diversity of modern organic chemistry. Enzyme kits may include ready-to-use, reproducible
biocatalysts. Its use opens up new avenues for the synthesis of active therapeutic compounds and
aids in drug development by synthesizing active components to construct scaffolds in a targeted
and preparative manner. This study summarizes current breakthroughs as well as notable instances of biocatalytic and chemoenzymatic synthesis. To assist organic chemists in the use of
enzymes for synthetic applications, it also provides some basic guidelines for selecting the most
appropriate enzyme for a targeted reaction while keeping aspects like cofactor requirement, solvent tolerance, use of whole cell or isolated enzymes, and commercial availability in mind.
The (Pro)renin Receptor - A Regulatory Nodal Point in Disease Networks
Authors: Funke-Kaiser Heiko , Unger Thomas
Published: October 2023

Experimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic
strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly
review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct
diseases in which the (P)RR is involved.

:

The first structural work on the (P)RR using AlphaFold, which was recently published by Ebihara
et al., is the center of this mini-review since it can mechanistically link the protein-protein interaction
level with the pathophysiological level.

:

More detailed insights into the 3D structure of the (P)RR and its interaction domains might guide
drug discovery on this novel target. Finally, antibody- and small molecule-based approaches to inhibit
the (P)RR are shortly discussed.
Review of the Role of Metabolic Factors in Determining the Post-surgical
Adhesion and its Therapeutic Implications, with a Focus on Extracellular
Matrix and Oxidative Stress
Authors: Tavakkoli Mahmoud , Khodashahi Rozita , Aliakbarian Mohsen , Rahimi Hoda , Ashrafzadeh Kiarash , Ferns Gordon , Khaleghi Ebrahim , Arjmand Mohammad-Hassan
Published: October 2023

The potential role of metabolic reprogramming in fibrogenesis has recently attracted interest. Extracellular matrix stiffness, inflammation, and
subsequent oxidative stress are essential mediators in the causation of fibrosis. The prevention of post-surgical adhesion is a challenge in medicine.
It is defined as a fibrotic disorder in which adhesive bands develop after abdominal or pelvic surgery. Despite many studies related to the
pathogenesis of post-surgical adhesion (PSA), many unknowns exist. Therefore, evaluating different pathways may help characterize and identify
the cause of fibrotic scar formation post-operation. Glucose and lipid metabolism are crucial metabolic pathways in the cell’s energy production
that may be targeted by hypoxia-induced factor alpha and profibrotic cytokines such as TGF-β to mediate fibrogenesis. Inhibition of upregulated
metabolic pathways may be a viable strategy for ameliorating post-surgical adhesion. In this review, we have discussed the potential role of altered
glucose and lipid metabolism in extracellular matrix (ECM) stiffness and oxidative stress as crucial mediators in fibrosis.
Antibacterial and Antimalarial Therapeutic Agents: A Patent Perspective
Authors: Zhang Hai-Long , Li Yongxia
Published: October 2023

Background:

Antibacterial and antimalarial drugs play a critical role in combating
infectious diseases. It is a continuous work to develop new types of antibacterial and antimalarial
drugs.

Objectives:

To better understand current landscape and association of antibacterial and antimalarial
agents, the European patent analysis was performed.

Methods:

Antibacterial and antimalarial agents were analyzed by patent analysis. Patent documents
from January 2003 to May 2022 were retrieved and analyzed.

Results:

The present study indicated there were virtually three therapeutic approaches for antibacterial
agents, including chemical drugs, biological products and siRNA technology. Chemical
drugs were a mainstream therapeutic approach for development of both antibacterial and
antimalarial agents. However, the present study found that in contrast to antimalarials, siRNA
technology had been initially explored as therapeutic strategy for antibacterial agents. Also, our
study is the first to show that there is a low correlation between antibacterial and antimalarial
agents.

Conclusion:

Globally, our study is the first one to show that it may be not a fast approach to
discover antimalarial drugs from antibacterial agents based on drug repurposing. siRNA technology
as therapeutic strategy had been explored and used in antibacterial field.
Linear Pneumatic Cylinder Assembly with Reduced Air Consumption
Authors: Rufer Alfred
Published: October 2023

The method of adding expansion work to pneumatic actuators is studied for
classical linear cylinders. The operating principle of new cylinder assemblies is
presented. A first simulation set illustrates the performance of the new assembly and
tries to define the parameters of a single cylinder which produces the same mechanical
performance. Acceleration, speed and reached position within a given time are the
conditions for the comparison. Then, the air consumption of both compared systems is
calculated. With an experimental set-up, a parasitic effect is observed, which consists
of a pre-expansion transient due to parasitic dead volumes related to the tubing and
internal volumes of the valves. A second assembly is realized with larger volumetry in
order to observe the dependency of the parasitic effect from the size of the cylinders.
For the control, a system with simpler control valves is also studied.
Study of Permanent Magnet Synchronous Motor With LQG Controller and Observer On The Hydraulic Pump System
Authors: Setiawan Paulus , Meilani Linda , Dermawan Denny , Kurniawan Freddy , Dinaryanto Okto
Published: October 2023

In today's aircraft industry, the flight control system and landing gear system cannot be separated from the role of the hydraulic technology system. As the prime mover of the hydraulic pump or actuator hydraulic system, a permanent magnet synchronous motor (PMSM) is used. This PMSM is a substitute for the role of conventional combustion engines, and PMSM is considered to have several advantages in increasing performance and efficiency. This research will develop a system to find parameter values for Linear Quadratic Gaussian (LQG) controllers in a hydraulic pump system that is installed as a load from PMSM and then observe and analyze the performance of the response of the synchronous motor system, namely in the form of changes in rotor rotation speed, torque electric power, and stator current on the q-axis. The results of the research on the characteristics of the PMSM implemented in the hydraulic pump system show that the LQG controller is more optimal when compared to the observer controller. The LQG controller is known to have a faster transient response, which is indicated by the value of the settling time improvement at no load, namely 116.67% for the observer controller and 364.705% without the controller. Then when the synchronous motor serves the nominal load, the rotational speed of the rotor produced in the steady state becomes 8.29% faster than the observer controller and 74.49% without the controller. This rotor's rotational speed affects the time the actuator needs to extend and retract motion.
The Performance of K-Nearest Neighbor (KNN) Approach for Estimating Extreme Rain Events based on CCTV Images Camera Data
Authors: Rahayu Soni Aulia , Sipayung Sinta Berliana , Witono Adi , Suprihatin Lilik S
Published: October 2023

Abstract—Hydrometeorological disasters such as flooding in urban areas are a big problem that must be managed. Indonesia as part of the maritime continent, has high rainfall variability, both temporally and spatially. Unfortunately, the density of instruments for measuring rainfall is still low. To solve the problem, this research will try to utilize and modify Closed Circuit Television (CCTV) cameras which have a large number in terms of quantity as instruments for measuring rainfall. The purpose of this research is to obtain rainfall image information and data generated by CCTV cameras. The image data is converted to quantitative rainfall data. The method used is the K-NN algorithm and machine learning. The research location is located in a corner of the city of Bandung with a geographical position of 60 53”30.49'S and 107.035” 12.27' E. The results of this research show that the K-NN algorithm can be applied to estimate rainfall data from CCTV images with an accuracy of more than 98%. The level of accuracy generated between CCTV camera image data and AWS is 94%. The level of accuracy is high means that CCTV camera image data can represent or be converted into quantitative rainfall data.
O eclipse de um músico plural: trajetória de António Augusto Urceira
Authors: Rodrigues Prada Soares Teresinha
Published: October 2023

O texto apresenta resultados de uma investigação sobre o músico lisbonense António Augusto Urceira, no que diz respeito aos seus dados biográficos e de sua trajetória musical. Ao ocupar-se de sua carreira artística, a interpretação de dados revelou que a pluralidade é a melhor maneira de descrever sua atividade, apresentada em ordem cronológica – do final da Monarquia, à chegada da República e finda no Estado Novo. Como desfecho, reconhecemos que seu trabalho com a guitarra clássica foi a ação mais bem registada e, através da análise, percebemos o quanto os repertórios que escolheu e sua performance foram inovadores para a primeira metade do século XX.
Employee surveys: guidance to facilitate effective action
Authors: Fraser Kathryn J. , Leach Desmond J. , Webb Sue
Published: October 2023

Modern employee surveys have the potential to add value to an organization by assisting planning and change. However, the survey literature shows that using the findings is a challenge (William Steinberg Consultants Inc., 2004). The aim of this article is to provide guidance on how to take action on an employee survey. The article defines employee surveys and explains the reason for their increasing use. Then, by combining information from the literature with the views of managers who frequently use employee surveys, we identify the main facilitators for action. These are: a clear action purpose for both the overall survey and individual topics; endorsement by senior management; and assignment of both a survey co-ordinator and topic specialists to plan and implement action. These personnel need expertise in the topics targeted for action plus knowledge of how to implement change.
Business and Work in the Future – Practitioners’ Day, Decent work and Beyond EAWOP congress, 2011
Authors: Dogge Hans Peter
Published: October 2023

This article was produced as a basis for further discussion from the German Contribution to the 2011 EAWOP conference - Practitioners’ Day and including the results of the Future Workshop of the 7 (Congress for Business Psychology, 2008 of the German Association of Psychologists - Business Psychology Section). This paper examines: trends in work and the business world; resulting questions; required contributions and challenges for Work and Organizational Psychologists and is intended as a basis for further discussion.
Promises in action: The role of employer brand, employee value proposition and employee experience in delivering on psychological contract expectations
Authors: Veldsman Dieter , van der Merwe Marna
Published: October 2023

The shifting world of work and the resultant impact on organizations has fundamentally changed the relationship between employees and employers. With the reality of changing workforce demographics, gig-workers, nomad work and evolving talent marketplaces placing organizational talent supply processes under pressure, there is a need to evaluate the effectiveness of people management practices to access talent pools. In particular, the impact of employer branding, the employee value proposition, and the employee experience on attracting and retaining talent has to be re-evaluated in light of shifting expectations. We propose that traditional human resource (HR) practices, which have predominantly been focused on procedural elements of the employee lifecycle, have to evolve to intentionally create more human-centric working environments. This implies incorporating principles from design thinking and servicebased design, which positions the human being as the focal point. A shift towards a more human-centric perspective should not be disconnected from the contextual realities of the organization and its objectives while also taking the dynamic nature of the evolving psychological contract into account. The purpose of this article can be described as follows. First, we aim to discuss the psychological contract as the focal point for aligning employer brand, employee value propositions and employee experience. Second, we propose an employee-centric design methodology for human resource practices and third, we illustrate the use and application of this method by applying it to the off-boarding process in a global organization.
Profil Kepemimpinan Kepala Sekolah Dasar Negeri dan Swasta di Kabupaten Sumedang
Authors: Ega Septi
Published: October 2023

Dalam sebuah organisasi baik formal maupun non formal dibutuhkan adanya seorang pemimpin. Dalam lembaga pendidikan sosok pemimpinnya yaitu kepala sekolah yang memiliki peran penting dalam menentukan dan mengelola sekolah. Status sekolah memiliki fungsi penting untuk kepemimpinan kepala sekolah yaitu antara sekolah negeri dengan sekolah swasta tentu memiliki perbedaan yang berpengaruh terhadap kebijakan sistem kepemimpinan yang akan dilakukan kepala sekolah. Sekolah negeri sering dianggap memiliki pemimpin yang unggul yang dibuktikan dengan sekolah favorit siswa dan identik dengan aturan yang tegas yang dibuat kepala sekolah untuk memajukan sekolah dan warga sekolah dari berbagai lingkup. Begitu pula dengan sekolah yang umum dengan yang kental dengan agama tentu memiliki sistem kebijakan kepala sekolah yang berbeda dengan sekolah umum. Dengan hal tersebut, maka penelitian ini bertujuan untuk melihat pengaruh status sekolah terhadap kebijakan sistem kepemimpinan kepala sekolah. Penelitian ini menggunakan metode kualitatif dengan desain studi kasus menggunakan teknik wawancara tidak langsung yaitu menggunakan google form dengan responden sebanyak 30 orang kepala sekolah Sekolah Dasar (SD) dan Madrasah Ibtidaiyah (MI) dari berbagai sekolah baik yang berstatus negeri maupun swasta di Sumedang. Dalam hasil penelitian dapat disimpulkan bahwa status sekolah memiliki pengaruh terhadap pengambilan sistem kebijakan kepemimpinan yang dilakukan kepala sekolah untuk memajukan kualitas sekolah yang dipimpinnya.
Tingkat Kompetensi Manajerial Kepala Sekolah Dasar
Authors: Oktaviani Firyal Fatin , Lestari Slamet
Published: October 2023

Tujuan penelitian ini adalah untuk mendeskripsikan (1) tingkat kompetensi manajerial kepala SD negeri se-Kecamatan Pandeglang dan Majasari, (2) faktor pendukung dan penghambat kepala SD negeri se-Kecamatan Pandeglang dan Majasari dalam menjalankan tugas manajerial, dan (3) fasilitas yang dibutuhkan oleh kepala SD negeri se- Kecamatan Pandeglang dan Majasari untuk menguatkan kompetensi manajerial. Pendekatan penelitian ini adalah deskriptif. Subjek penelitiannya yaitu kepala SD negeri se-Kecamatan Pandeglang dan Majasari, Kabupaten Pandeglang sebanyak 40 orang. Pengumpulan data menggunakan kuesioner tertutup dan kuesioner terbuka. Teknik analisis data yang digunakan untuk kuesioner tertutup yaitu statistik deskriptif dengan persentase, sedangkan teknik analisis data yang digunakan untuk kuesioner terbuka yaitu metode deskriptif. Validitas data kuesioner tertutup menggunakan teknik Pearson Corelation Product Moment dan reliabilitas data menggunakan teknik Cronbach’s Alpha, sedangkan validitas dan reliabilitas data kuesioner terbuka menggunakan Expert Judgment. Hasil penelitian menunjukkan: (1) kompetensi manajerial kepala SD negeri se-Kecamatan Pandeglang dan Majasari berada pada kategori sangat tinggi dengan persentase sebesar 82,56%. (2) faktor yang mendukung kepala sekolah dalam menjalankan tugas manajerial adalah sub aspek man (manusia) seperti stakeholder internal. Sub aspek man (manusia) juga menjadi faktor yang menghambat kepala sekolah dalam menjalankan tugas manajerial. (3) fasilitator yang dibutuhkan oleh kepala sekolah untuk menguatkan kompetensi manajerial dilihat dari aspek sumber daya manusia adalah sub aspek pendidik dan tenaga kependidikan, sedangkan fasilitas yang dibutuhkan oleh kepala sekolah dilihat dari aspek sumber daya non manusia adalah sub aspek prasarana sekolah.
Pengembangan Iklim Sekolah melalui Penerapan Pendidikan Karakter di Sekolah Dasar
Authors: Supriyana Heri , Lestari Slamet
Published: October 2023

Penelitian ini bertujuan untuk mengetahui sejauhmana pengembangan iklim sekolah melalui penerapan pendidikan karakter di SDN Percobaan 2 Yogyakarta. Jenis penelitian ini fenomenologi dengan pendekatan deskriptif kualitatif. Lokasi penelitian di SDN Percobaan 2 Yogyakarta. Metode pengumpulan data melalui wawancara dan studi dokumen dengan partisipan utama kepala sekolah sedang partisipan lain yaitu guru dan siswa. Analisa data menggunakan model interaktif. Hasil penelitian ini berupa eksplanasi tentang pengembangan iklim sekolah melalui penerapan pendidikan karakter yaitu berupa kegiatan-kegiatan yang diciptakan oleh kepala sekolah dalam rangka meningkatkan karakter anak yang meliputi; karakter nasionalis seperti kegiatan upacara bendera setiap hari senin, upacara peringatan-peringatan hari besar nasional, lomba-lomba peringatan hari kemerdekaan, dan menyanyikan lagu wajib nasional dipagi hari; karakteristik religiusitas seperti kegiatan pelaksanaan sholat dhuha dan sholat dhuhur secara berjamaah, baca tulis Al-Qur’an (BTBQ), dan pendalaman al-kitab, perayaan hari besar agama, serta kegiatan dompet kemanusiaan; karakter mandiri seperti pengadaan kegiatan perkemahan, pengadaan perpustakaan, sudut baca, mading baca, kantin sehat; karakter integritas meliputi kegiatan pembiasaan 5S (Salam, Sapa, Senyum, Sopan, Santun), kantin kejujuran, pentas seni, dan mengikutkan lomba-lomba akademik serta non akademik; karakter gotong royong seperti kegiatan kerja bakti rutin dan perawatan taman-taman sekolah.