bluuebunny/crossref_metadata_2025 huggingface dataset:
Korelasi Nutrien Nitrat Fosfat Pada Sedimen terhadap Persentase Tutupan Lamun di Pulau Harapan dan Pulau Kelapa Dua, Kepulauan Seribu, DKI Jakarta
Authors: Putri Safira Aisha , Suryono Suryono , Ario Raden
Published: November 2022

Nutrien nitrat dan fosfat merupakan salah satu faktor pembatas yang berpengaruh terhadap proses pertumbuhan pada ekosistem laut terutama lamun. Penelitian dilaksanakan pada bulan November - Desember 2021 dengan tujuan untuk mengetahui konsentrasi nutrien nitrat dan fosfat pada sedimen serta korelasinya terhadap tutupan lamun di Pulau Harapan dan Pulau Kelapa Dua. Metode yang digunakan dalam penelitian ini adalah metode survei. Pemihan stasiun penelitian menggunakan purposive sampling. Analisis konsentrasi nutrien nitrat dilakukan dengan metode IK-BP2-MU-A-08-2005 dan fosfat dengan SNI 06-6989.31-2005. Analisis korelasi dilakukan dengan metode person-correlation. Hasil menunjukkan bahwa rata – rata tutupan lamun di Pulau Harapan sebesar 43,94% dan Pulau Kelapa Dua 29,42 %. Korelasi nutrien terhadap tutupan lamun di Pulau Harapan menunjukkan nitrat sebesar 0,63 dan fosfat 0,19 sedangkan di Pulau Kelapa Dua nilai korelasi menunjukkan nitrat sebesar 0,43 dan fosfat -0,24. Kesimpulan penelitian menyatakan bahwa konsentrasi nutrien pada Pulau Harapan memiliki hubungan kuat positif untuk nitrat dan sangat rendah untuk fosfat, sedangkan di Pulau Kelapa Dua menunjukkan hasil cukup positif untuk nitrat dan sangat rendah untuk fosfat. Nitrate and phosphate nutrients are one of the limiting factors that affect the growth process in marine ecosystems, especially seagrass. The research was carried out in November - December 2021 with the aim of knowing the concentration of nitrate and phosphate nutrients in sediments and their correlation to seagrass cover on Harapan Island and Kelapa Dua Island. The method used in this research is a survey method. Selection of research stations using purposive sampling. Analysis of the nutrient content of nitrate was carried out with the method of IK-BP2-MU-A-08-2005 and phosphate with SNI 06-6989.31-2005. Correlation analysis was carried out using the person-correlation method. The results showed that the average seagrass cover on Harapan Island was 43.94% and Kelapa Dua Island was 29.42%. Nutrient correlation to seagrass cover in Harapan Island showed nitrate of 0.63 and phosphate of 0.19 while in Kelapa Dua Island the correlation value showed nitrate of 0.43 and phosphate of -0.24. The conclusion of the study was that the nutrient concentration on Harapan Island had a strong positive relationship for nitrate and very low for phosphate, while in Kelapa Dua Island the results were quite positive for nitrate and very low for phosphate.
Makanan Dan Kebiasaan Makan Kepiting Merah (Thalamita spinimana, Dana 1852) Di Perairan Dompak, Tanjungpinang, Kepulauan Riau
Authors: Alwi Calvin , Muzammil Wahyu , Susiana Susiana
Published: November 2022

Perairan Dompak, Kota Tanjungpinang, Provinsi Kepulauan Riau merupakan salah satu area penangkapan krustasea, salah satunya adalah kepiting merah (Thalamita spinimana). Belum adanya penelitian terkait aspek makanan dan kebiasaan makan kepiting merah (T. spinimana) di Perairan Dompak menjadikan penelitian terkait aspek tersebut penting untuk dilakukan. Tujuan penelitian ini adalah untuk mengetahui komposisi makanan kepiting merah (T. spinimana) khususnya Perairan Dompak Kota Tanjungpinang Kepulauan Riau. Penelitian ini menggunakan metode survei. Pengambilan sampel kepiting merah (T. spinimana) dilakukan selama 2 bulan sebanyak 4 kali. Analisis data untuk mengetahui kebiasaan makanan kepiting merah (T. spinimana) menggunakan index of preponderance (IP). Hasil penelitian diketahui bahwa jumlah kepiting merah yang diperoleh sebanyak 34 ekor, terdiri dari 21 ekor kepiting merah betina dan 13 ekor kepiting merah jantan. Kelompok makanan kepiting merah (T. spinimana) terdiri dari mikroalga, krustasea, dan detritus. Hasil indeks bagian terbesar / IP diketahui bahwa makanan utama kepiting merah di Perairan Dompak adalah kerang, sedangkan makanan pelengkap adalah detritus dan fitoplankton, makanan tambahan yaitu zooplankton. Nilai indeks kepenuhan lambung kepiting merah (T. spinimana) pada waktu malam hari (1,11), pagi hari (0,96) dan siang hari (0,63). Kepiting merah (T. spinimana) di Perairan Dompak dominan melakukan aktivitas makan pada malam hari. Dompak Waters, Tanjungpinang City, Riau Islands Province is one of the areas for catching crustaceans, one of which is the red swimming crab (Thalamita spinimana). The absence of research related to food and feeding habit aspects of red swimming crab in Dompak Waters makes research related to these aspects important to do. The purpose of this study was to determine the food composition of red swimming crab, especially Dompak waters, Tanjungpinang City, Riau Islands. This study used a survey method. Sampling of red swimming crab was carried out for 2 months with 4 sampling times. Data analysis to determine the food habit of red swimming crab using the index of preponderance (IP). The results showed that the number of crabs obtained was 34, consisting of 21 female red swimming crab and 13 male red swimming crab. The red swimming crab food group consists of microalgae, crustaceans, and detritus. The results of the largest share / IP index show that the main food of red swimming crab in Dompak Waters is bivalvia, while the complementary food are detritus and phytoplankton, the additional food is zooplankton. The index value of stomach fullness of red swimming crab at night (1.11), morning (0.96) and afternoon (0.63). This result is known that the red swimming crab in Dompak waters eats predominantly at night.
Antimicrobial, anti-adhesion, anti-biofilm properties of goji berry (Lycium barbarum) against periodontal bacteria: potential benefits for periodontal diseases
Authors: Sanghavi Amee Dilip , Chopra Aditi , Shah Ashmeet , Lobo Richard , Shenoy Padmaja A.
Published: November 2022

Objectives

Lycium barbarum, commonly known as goji berry, Himalayan berry, or Tibetian berry, is emerging as a popular “superfood” with anti-inflammatory and antioxidant properties. However, its use for the management of oral inflammatory diseases has not been explored. The present study aims to evaluate the antimicrobial, anti-adhesion, anti-biofilm, and cytotoxic properties of an ethanolic extract of L. barbarum (LBE) against common oral and periodontal pathogens.

Methods

The antimicrobial properties of LBE against five potential periodontal pathogens (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Tanerella forsythia) were tested and compared to chlorhexidine and doxycycline using serial dilution and disc diffusion assay. The MTT Assay was performed for evaluating the cytotoxicity and cell viability of the LBE on the gingival fibroblast and modified keratinocyte cell lines. The anti-adhesion and anti-biofilm properties of LBE against P. gingivalis at its minimal bactericidal value were also assessed.

Results

LBE inhibited the growth of periodontal pathogens as compared to control, however, the zone of inhibition of LBE was less when compared to doxycycline and chlorhexidine. The de novo extract showed a maximum zone of inhibition against Tf and Aa. The LBE extract was also compatible to gingival fibroblast tissues and oral keratinocytes at 1 mg/mL.

Conclusions

L. barbarum is a promising alternative to Chlorhexidine for the management of oral and periodontal infections.
Maximum work configuration of finite potential source endoreversible non-isothermal chemical engines
Authors: Chen Lingen , Xia Shaojun
Published: November 2022

Chemical engine is an abstract model of some devices, such as solid state, photochemical, and electrochemical devices, photovoltaic cell, and mass exchangers. Finite chemical-potential source is one of its features. Finite time thermodynamics provides effective theoretical tool for determining performance limits for given thermal systems, and determining optimal process paths of thermal systems for given performance objectives. Endoreversible model is its basic model. A model of endoreversible non-isothermal chemical engines operating between a finite chemical-potential source and an infinite chemical-potential sink with mass resistance and heat resistance is established. Mass transfer processes between chemical potential reservoir and working fluid of the model are assumed to obey Onsager equations in linear irreversible thermodynamics. With a fixed cycle period, optimal cycle configuration for the maximum work output of the model is derived by applying optimal control theory. The results obtained include optimal performance and optimal path results in many previous literatures, and can provide some theoretical guidelines for optimal designs of practical chemical plants.
Phototherapy-induced hypocalcemia and hypoparathyroidism in icteric term newborns
Authors: Beser Esra , Cakir Ufuk , Karacaglar Nazmiye Bengu , Kucukoglu Keser Merve , Ceran Burak , Tugcu Ali Ulas , Tayman Cuneyt
Published: November 2022

Objectives

Phototherapy is demonstrated to cause hypocalcemia by decreasing melatonin levels and increasing cortisol levels. However, the relationship between parathyroid hormone (PTH) level and calcium has not been previously evaluated in patients receiving phototherapy. Our study aimed to evaluate the effect of phototherapy on ionized calcium (iCa), total calcium (tCa), corrected calcium (cCa), magnesium (Mg), phosphorus (P), 25-hydroxyvitamin D (25(OH)D), and PTH levels.

Methods

Infants who were born at term and received inpatient phototherapy for indirect hyperbilirubinemia were included in our study. The patients’ gestational age, birth weight, and phototherapy durations were recorded. Total bilirubin, albumin, iCa, tCa, cCa, Mg, 25(OH)D, and PTH levels before and after phototherapy were compared. Laboratory results were also compared between patients who received phototherapy for ≤24 h, 25–47 h, and ≥48 h.

Results

A total of 166 term infants were included in the study. The mean duration of phototherapy was 31.9 ± 9.2 h. Albumin levels before and after phototherapy were similar (p=0.246). However, there were significant decreases in iCa, tCa, cCa, Mg, 25(OH)D, and PTH levels after phototherapy (p<0.001), while P level was significantly increased after phototherapy (p<0.001). In addition, P levels increased with >24 h of phototherapy, while iCa, tCa, cCa, Mg, 25(OH)D, and PTH levels decreased significantly with ≥48 h of phototherapy (p=0.002, p=0.008, p=0.001, p=0.012, and p<0.001, respectively).

Conclusions

This study demonstrates that PTH suppression is one of the causes of phototherapy-induced hypocalcemia.
Zur sozialen Herkunft deutscher Admirale und Luftwaffengenerale im Kalten Krieg
Authors: Loch Thorsten , Müller Daniel F. , Naumann André , Schulz Stephanie
Published: November 2022

Auf Grundlage sozialempirisch erhobener Primärdaten – gewonnen aus den militärischen Personalakten – werden in dieser Dokumentation anhand von Schaubildern, Diagrammen und Tabellen sozialstatistische Befunde für die Spitzen der Luftwaffen und Marinen beider deutscher Staaten der Forschung zur Verfügung gestellt. Je nach Erkenntnisinteresse und Fragestellung können die vorliegenden Daten als Bezugswerte einer umfassenden Deutung zugeführt werden. Um sie in ihren militärgeschichtlichen Kontext einzuordnen, wird das historiografische Konzept des »Primats der sozialen Herkunft« skizziert, die zugrundliegenden Quellen und die Methode vorgestellt, das Erkenntnispotenzial der Daten angedeutet und abschließend weiterführende Perspektiven für die Militärgeschichtsschreibung aufgezeigt. Verbunden ist die Dokumentation mit der Forderung, deutsches Militär im 19. und 20. Jahrhundert nicht mehr ausschließlich aus einer sozialdeterministischen Perspektive zu betrachten, sondern es vielmehr als Profession zu begreifen.
Hunting for Hide. Investigating an Other-Than-Food Relationship Between Stone Age Hunters and Wild Animals in Northern Europe
Authors: Skandfer Marianne
Published: November 2022

In archaeological hunter-gatherer research, animals are primarily seen as food. Alternatively, they are proposed to serve as symbols and devices for social structuring of human societies. A growing body of literature in humanities and social sciences now looks into the role of animals as social and sentient co-beings. It is becoming increasingly clear that the roles of animals as other-than-food providers are severely overlooked in Mesolithic research. This article considers hide as a vital resource in northern hunter-gatherer societies. Hide processing and manufacture in ethnographic records from the circumpolar region and experimental investigations are presented, followed by an analytical review of archaeological data from mid-Holocene coastal habitation sites in Norway. The results show that hide work was a central activity, and that various stages of hide processing may have taken place at different sites. It is suggested that hide procurement and processing would have required close planning and scheduling. Based on ethnographic accounts it is suggested that the different processing stages, combining raw materials and animal qualities into man-made objects, are articulations of human-animal social entanglements. Identifying practices related to hide processing in the archaeological record and viewing them as expressions of human-animal relationships, can contribute to fuller insight into Stone Age hunter-gatherer societies.
Specification of International Chemical Identifier (InChI) QR codes for linking labels on containers of chemical samples to digital resources (IUPAC Recommendations 2021)
Authors: Frey Jeremy G. , Hartshorn Richard M. , McEwen Leah R.
Published: November 2022

This article discusses the ways of linking physical objects to digital information relevant to chemical entities, specifically those that can be described by the use of the IUPAC International Chemical Identifier (InChI). It makes recommendations on the form of the computer readable components of labels provided for chemicals and materials that are used on product/sample containers and on the associated documentation that is used when transporting these containers (either internally or during export/import). The focus is on specification of the content of the 2D Quick Response bar codes required to describe the molecular content of the containers and link to digital resources to supplement that provided on a physical label. The necessary technical and (possible) business infrastructure necessary to support the use of the InChI and InChIKey for rapid recall of relevant information is considered here and suggestions are made.
Removal of heavy metals from wastewater using synthetic chelating agents
Authors: Nyamato George S. , Apollo Seth
Published: November 2022

The issue of heavy metal water pollution is one that concerns everyone. Both plants and humans are negatively impacted by heavy metals. Consequently, the environment and water resources require an efficient heavy metal remediation technique. In this context, a series of compounds were investigated as potential chelating agents for the removal of Cu, Zn, Cd, and Pb cations from water. By solvent extraction, it was shown that the chelating ligands’ affinity for Cu, Zn, Cd, and Pb as indicated by the extraction performance was in the following order: Cu > Zn > Cd > Pb. The size and electrical characteristics of the metal as well as the ligand structure affect how well L1–L6 extracts that metal.
Semiotic relation in literary photobooks: the case of Leminski’s Quarenta Clics em Curitiba
Authors: Fernandes Ana , Queiroz Joao
Published: November 2022

How should one describe the irreducible relationships in photopoetry observed in intermedial literary photobooks? According to most authors, in literary photobooks, the verbal sign system is linked to the photographic image as a bidirectional interaction, creating a coupled system that can be seen as a new sign system. Mutually modulatory influences link verbal text and photography. But the nature of such influences needs to be explained in detail and with accuracy. What kind of relation are we dealing with? Many authors have tried to explain this phenomenon through several epistemic metaphors. The problem is that these metaphors are rarely subjected to any general theory of meaning. Surprisingly, this is not even mentioned as a problem. In this article, we propose a general semiotic model to describe the irreducible photography-poetry relation, derived from C. S. Peirce’s pragmatic theory of signs, and we also present some preliminary results of the analysis of Quarenta Clics em Curitiba, a photobook by Paulo Leminski and Jack Pires. Our purpose here is to introduce and explore this model to describe the photography-poetry relationship in coupled systems. This relationship is decomposed, in the functional roles occupied by poems and photographs, into a sign-object-interpretant relation. The triadic irreducibility that characterizes semiosis (à la Peirce) is the main property applied to photograph-poetry coupling in Quarenta Clics em Curitiba.
Collapse-revival of entanglement in a non-commutative harmonic oscillator revealed via coherent states and path integral
Authors: Madouri Fethi , Merdaci Abdeldjalil , Sbeouelji Tarek
Published: November 2022

We develop an approach using coherent states and path integral to investigate the dynamics of entanglement in a simple two-dimensional non-commutative harmonic oscillator. We start by employing a Bopp shift to convert the Hamiltonian describing the system into a commutative equivalent one. This allows us to construct coherent states and calculate the propagator in standard way. By deriving the explicit expression of the time-dependent coherent states and considering its connection with the number states, we provide exact results for evaluating the degree of entanglement between the ground state and any excited state through the purity function. The interesting emerging result is that, as long as the non-commutativity parameter is non-zero, our system exhibits the phenomenon of collapse and revival of entanglement.
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress
Authors: Lagage Valentine , Chen Victor , Uphoff Stephan
Published: November 2022

Understanding the interplay between phenotypic and genetic adaptation is a focus of evolutionary biology. In bacteria, the oxidative stress response prevents mutagenesis by reactive oxygen species (ROS). We hypothesise that the stress response dynamics can therefore affect the timing of the mutation supply that fuels genetic adaptation to oxidative stress. We uncover that sudden hydrogen peroxide stress causes a burst of mutations. By developing single‐molecule and single‐cell microscopy methods, we determine how these mutation dynamics arise from phenotypic adaptation mechanisms. H2O2 signalling by the transcription factor OxyR rapidly induces ROS‐scavenging enzymes. However, an adaptation delay leaves cells vulnerable to the mutagenic and toxic effects of hydroxyl radicals generated by the Fenton reaction. Resulting DNA damage is counteracted by a spike in DNA repair activities during the adaptation delay. Absence of a mutation burst in cells with prior stress exposure or constitutive OxyR activation shows that the timing of phenotypic adaptation directly controls stress‐induced mutagenesis. Similar observations for alkylation stress show that mutation bursts are a general phenomenon associated with adaptation delays.
Duodenal-jejunal bypass liner for treatment of T2DM and obesity: 4-year outcomes in the ﬁrst National Health Service (NHS) EndoBarrier service
Authors: Ryder Robert E , Yadagiri Mahender , Burbridge Wyn , Irwin Susan P , Gandhi Hardeep , Bashir Tahira , Allden Rachael A , Wyres Melanie , Cull Melissa , Bleasdale John P , Fogden Edward N , Anderson Mark R , Sen Gupta Piya
Published: November 2022

Background and aims: EndoBarrier is a 60cm duodenal-jejunal bypass liner endoscopically implanted for up to one year and designed to mimic the bypass part of roux-en-Y bariatric surgery. There is uncertainty concerning the extent to which improvements associated with EndoBarrier treatment are sus-tained once the liner has been removed. We aimed therefore to establish an EndoBarrier service for refractory diabesity and to continue to monitor the people with diabetes after EndoBarrier removal.
Methods: Between October 2014 and November 2017, we implanted 62 EndoBarriers in our NHS service. All had been removed by November 2018. Outcomes were monitored in a registry.
Results: As of November 2021, all patients reached three years after EndoBarrier removal and of these 43/62 (69%) (mean±SD age 51.6 ± 7.6 years, 55.8% male, 55.8% white ethnicity, median [IQR] diabetes duration 14.6 [8 – 21] years, 62.8% insulin-treated, mean±SD BMI 41.7±7.3 kg/m2) attended follow-up. In those who attended, during EndoBarrier implantation mean±SD HbA1c fell by 20.6±19.6 mmol/mol from 76.3±19.2 to 55.7±11.1 mmol/mol (p<0.001) (by 1.9±1.8% from 9.1±1.8% to 7.2±1.0% [p<0.001]), weight fell by 17.4±9.1 kg from 123.3±30.0 kg to 105.9±30.8 kg (p<0.001), BMI fell from 41.7±7.3 to 35.6±7.7 kg/m2 (p<0.001), systolic blood pressure from 138.7±14.4 to 125.4±14.7 mmHg (p<0.001), cholesterol from 4.6±1.0 to 3.7±0.7mmol/L (p<0.001), and serum alanine aminotransferase from 30.8±17.2 to 19.3±11.2 U/L (p<0.001). In those taking insulin median (IQR) total daily insulin dose reduced from 114 (54–180) to 20 (0–65) units (n=27, p<0.001); 10/27 (37%) insulin-treated people were able to discontinue insulin. Three years after EndoBarrier removal 33/43 (77%) maintained most of the improvement achieved with EndoBarrier whilst 10/43(23%) reverted to baseline. Of those deteriorating 9/10(90%) had depression and/or bereavement and/or major health problems/disability. 10/62(16%) required early Endo-Barrier removal for adverse events or symptoms; all 10 fully recovered after removal and most derived signiﬁcant beneﬁt.
Conclusions: Our data demonstrate that EndoBarrier is highly effective in people with refractory diabesity, with mainte-nance of signiﬁcant improvement three years after removal in 77% of cases.
The Relationship Between Participant Satisfaction, Perceived Service Quality, and Expenditures in A Sports Event
Authors: Srisiri Sununta
Published: November 2022

This research aimed to propose a model for the enhancement of service quality of the 2nd Thailand Open Master Games 2022 in Thailand. Data were collected from a sample survey of 583 participants i.e., athletes, referees, coaches, officials, team managers, volunteers, and all involved. A simple sampling was used. A particular focus of the study is if and how participant satisfaction influences participant’ expenditures. It is hypothesized and argued that expenditure depends on satisfaction relative to perceived service quality. Descriptive and regression analytical techniques were employed for data analysis. Three primary dimensions in service quality were identified in the sports context: sporting event quality, staff quality, and venue and sports facilities quality. It is empirically found that perceived service quality affected participants' satisfaction and those participants with satisfaction greater than their perceived service quality during the visit spend significantly more. The management in sports events could apply the findings in delivering services with a view to boosting customers. A limitation of this study, however, is that the satisfaction is not measured systematically taking into consideration several dimensions of satisfaction that should be addressed in future research.
Ergosterol supplementation improves furfural tolerance of Saccharomyces cerevisiae to produce ethanol and its underlying mechanism
Authors: Jia Youpiao , Zhang Qingyan , Dai Jun , Zheng Xueyun , Meng Xianzhi , Zhou Ranran , Yang Haitao , Yao Lan , Chen Xiong
Published: November 2022

Furfural produced during lignocellulose pretreatment to reduce the recalcitrance inhibits the growth of Saccharomyces cerevisiae and reduces ethanol yield. To reduce the adverse effect of furfural on S. cerevisiae, exogenous ergosterol was supplemented and the impact on S. cerevisiae under furfural stress was studied. The lag phage was shortened by 50%, and the maximum ethanol yield was increased by 158% with 50 mg/L ergosterol supplementation under 4 g/L furfural stress. Flow cytometry analysis results showed that permeable cells and intracellular reactive oxygen species were decreased by 45 and 53%, respectively with the addition of ergosterol under furfural stress. The fatty acid composition of S. cerevisiae was changed; the intracellular glycerol and ergosterol content was increased after ergosterol supplementation. The saturation of fatty acid was increased. Addition of ergosterol promoted cell growth by decreasing oxidative stress. Under 4 g/L furfural stress, the lag phage of S. cerevisiae BY4741 (erg3△) and S. cerevisiae BY4741 (erg5△) was longer than that of S. cerevisiae BY4741, and the maximum ethanol concentration was decreased.
Mediacijos (sutaikymo) smurto artimoje aplinkoje atvejais galimybės Lietuvoje
Authors: Michailovič Ilona
Published: November 2022

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Benzonatate Exposure Trends and Adverse Events
Authors: Kim Ivone , Goulding Margie , Tian Fang , Karami Sara , Pham Tracy , Cheng Carmen , Biehl Ann , Muñoz Monica
Published: November 2022

BACKGROUND AND OBJECTIVES

Adverse events (AE), including death, occur in children with benzonatate use. This study aims to understand recent trends in benzonatate exposure and clinical consequences in pediatric patients.

METHODS

This retrospective analysis of data from IQVIA pharmacy drug dispensing, National Poison Data System, National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance Project, FDA Adverse Event Reporting System, and the medical literature evaluated exposure trends and medication-related AEs with benzonatate. Trends for comparator narcotic and nonnarcotic antitussive medications were analyzed where possible for context.

RESULTS

During the study period, pediatric benzonatate prescription utilization increased but remained low compared with pediatric utilization of dextromethorphan-containing prescription antitussive medications. Among the 4689 pediatric benzonatate exposure cases reported to US poison control centers from 2010 to 2018, 3727 cases (80%) were for single-substance exposures. Of these, 3590 cases (77%) were unintentional exposures and most involved children 0 to 5 years old (2718 cases, 83%). Cases involving intentional benzonatate exposure increased among children 10 to 16 years old with a more pronounced increase for multiple-substance exposures. Most benzonatate cases involving misuse or abuse were for children 10 to 16 years old (59 cases, 61%). The proportion of cases with serious adverse effects was low. There were few cases annually of serious AEs with benzonatate in children.

CONCLUSIONS

There were rising patterns of unintentional ingestion of benzonatate in children 0 to 5 years old and intentional benzonatate ingestion in children 10 to 16 years old. Rational prescribing and improved provider and caregiver awareness of benzonatate toxic effects may reduce risks associated with benzonatate exposure.
Multimodality Imaging in Valvular Structural Interventions
Authors: Grigoryan Karine , Demetrescu Camelia , Kasouridis Ioannis , Abiola Olukayode , Masci Pier Giorgio , Oguz Didem , Benedetti Giulia , Mak Sze Mun , Parwani Purvi , Preston Rebecca , Chiribiri Amedeo , Hancock Jane , Patterson Tiffany , Redwood Simon , Prendergast Bernard , Grapsa Julia
Published: November 2022

Structural valvular interventions have skyrocketed in the past decade with new devices becoming available and indications for patients who would previously have been deemed inoperable. Furthermore, while echocardiography is the main imaging tool and the first line for patient screening, cardiac magnetic resonance and CT are now essential tools in pre-planning and post-procedural follow-up. This review aims to address imaging modalities and their scope in aortic, mitral and tricuspid structural valvular interventions, including multimodality imaging. Pulmonary valve procedures, which are mostly carried out in patients with congenital problems, are discussed. This article presents a guide on individualised imaging approaches on each of the available interventional procedures.
The syntax of exceptive constructions in Arabic
Authors: Saeed Sameerah T.
Published: November 2022

This paper investigates the underlying structure of exceptive constructions with the Arabic exceptive marker ’illā and reveals the existence of two types of constructions: r(estrictive)-exceptives and s(ubtractive)-exceptives. The underlying factor that distinguishes these two constructions relates to the existence of a subtraction domain in s-exceptive constructions and its absence in r-exceptives. This distinction suggests that the exceptive marker ’illā ‘except' has a different syntactic function in these two constructions. Furthermore, this difference in the functional status of ’illā suggests a different internal and external structure of the ’illā-XP in each of these constructions. I argue that while the ’illā-XP in r-exceptive constructions projects a R-ExP, involving a covert antecedent in the form of the NPIs ’aḥad ‘one' or shay’ ‘thing’ and is a nominal adjunct, in s-exceptive constructions the ’illā-XP forms an S-ExP and can be classified into connected and free exceptives.
COVID–19 primer immunhiányos betegekben
Authors: Maródi László
Published: November 2022

Összefoglaló. Az új típusú koronavírus (SARS-CoV-2) okozta pandémia
súlyos terhet és nagy kihívást jelent a fertőzésekkel szemben általában is
fogékony, szerteágazó immunológiai és genetikai hátterű, primer immundeficiens
(PID-) betegek számára. Az eddigi megfigyelések arra utalnak, hogy a
SARS-CoV-2-fertőzés és a súlyos COVID–19 mortalitása nem elsősorban az
immunológiai alapbetegséggel, hanem sokkal inkább egyéb, a PID talaján
megelőzően kialakult (például bronchiectasia, asthma, autoimmun betegség stb.)
vagy attól független krónikus társbetegséggel (például diabetes, krónikus szív-
és érrendszeri vagy vesebetegség) és szervi károsodással függ össze. A betegek
egy kis csoportjában az I. típusú interferon-immunitás zavarát okozhatják
génmutációk vagy autoantitestek termelése. A közleményben az eddig közölt adatok
alapján beszámolunk a SARS-CoV-2-fertőzés és a COVID–19 lefolyásáról és
mortalitásáról PID-betegekben. Orv Hetil. 2022; 163(5): 166–170.

Summary. The pandemic caused by the novel coronavirus (SARS-CoV-2)
has resulted in tremendous challenges to the management of patients with primary
immunodeficiencies (PIDs) representing a wide range of immunological and genetic
entities. Preliminary data suggest that patients with PID would be at increased
risk of severe disease and mortality from this newly emerged coronavirus.
However, morbidity and mortality by SARS-CoV-2 may depend only partly on
specific defect of immunity. Most of disease morbidity and mortality has been
published to be related to previous damage of organs and tissues that had
developed on the bases of PID before contracting SARS-CoV-2 or other,
PID-independent disorders. In a small fraction of patients, impaired type I
interferon immunity was found to predispose PID patients to severe coronavirus
disease. In this review, we provide an update on published data about SARS-CoV-2
infections and COVID–19 in various PIDs. Orv Hetil. 2022; 163(5): 166–170.
A focalis nodularis hyperplasia multimodális kezelése
Authors: Pekli Damján , Kokas Bálint , Bárdos Dávid , Fülöp András , Pajor Péter , Hahn Oszkár , Illyés Ildikó , Kovács Attila , Szijártó Attila
Published: November 2022

Összefoglaló. A focalis nodularis hyperplasia (FNH) a máj második
leggyakrabban előforduló benignus góca. Nem malignizálódik, így a jelenlegi
ajánlások szerint eltávolítása relatív indikációt képez. Kezelését illetően több
különböző módszer is ismert. A közlemény célja, hogy összefoglalót adjon az FNH
ellátásáról és két esetben bemutassa az alternatív kezelési lehetőségeket. Egy
40 éves nőbetegnél hasi panaszok miatt indult kivizsgálás során a májban
CT-morfológiailag FNH igazolódott. A laesio lokalizációját figyelembe véve, a
sebészeti reszekció magas rizikója miatt, transarterialis embolisatio (TAE)
mellett döntöttünk. Többszörös kezelést követően a kontroll képalkotó
vizsgálatok alapján jelentős regressziót értünk el, mindemellett a beteg
panaszmentessé vált. Egy 25 éves nőbetegnél hasi panaszok miatt történt
MR-vizsgálat igazolt FNH-t. Az elhelyezkedésre tekintettel TAE-t végeztünk, a
beteg azonban ezúttal nem vált teljesen panaszmentessé. Definitív megoldásként
májreszekció történt, melyet követően panaszai megszűntek. Tünetmentes FNH
felfedezésekor elegendő lehet a betegek hosszú távú követése. Tünetek, illetve
nagy műtéti kockázat esetében a malignus májtumoroknál rutinszerűen alkalmazott
TAE az FNH-ban akár önmagában vagy sebészi kezeléssel kombinálva is eredményesen
alkalmazható. Kisebb rizikó esetén a legmegfelelőbb választás a primer
laparoszkópos reszekció. Orv Hetil. 2022; 163(15): 606–612.

Summary. Focal nodular hyperplasia (FNH) is the second most common
benign mass of the liver. According to the current recommendations, removal
makes relative indication. Several different treatment methods are known. The
purpose of the paper is to provide a summary of FNH care and to present
alternative treatment options in two cases. A 40-year-old woman was investigated
for abdominal complaints; CT scan confirmed FNH of the liver. Given the
localization of the lesion, we chose transarterial embolization (TAE) due to the
high risk of surgical resection. After multiple treatments, regression was
achieved, and the patient became asymptomatic. Painful FNH in a 25-year-old
female was confirmed by MRI. The lesion was dominantly seen in segment 1,
causing vena cava compression and collaptiform episodes. As a definitive
solution, liver resection was performed, after which her complaints ceased.
Long-term follow-up of patients may be sufficient when asymptomatic FNH is
detected. In the case of symptoms or high risk of surgery, TAE can be used
effectively by FNH either alone or in combination with surgical treatment. For
lower-risk patients, primary laparoscopic resection is the most appropriate
choice. Orv Hetil. 2022; 163(15): 606–612.
Emlődaganat nyelőcsőszűkületet okozó késői áttéte
Authors: Balázs Ákos , Vass Tamás , Szíjártó Attila
Published: November 2022

Az emlőtumor nyelőcső szűkületét okozó áttéte a viszonylagos ritkasága, nehéz
felismerhetősége és vizsgálatokkal való nehéz kimutathatósága miatt jelentős
diagnosztikus és terápiás kihívást jelent. Esetünkben a primer daganat kezelését
követően 19 évvel jelentkező, lassú progressziójú dysphagia kivizsgálása
megtévesztő eredményt produkált. A benignus folyamatnak tartott szűkület tágító
kezelése kapcsán kialakult perforációs szövődmény miatt a nyelőcső transhiatalis
exstirpatiójára kényszerültünk. Az eltávolított nyelőcső pótlását egy ülésben,
ortotopikus úton felvitt csőgyomorral végeztük. Kezelési taktikánk,
kényszerűségből, több ponton eltért a rutinszerű eljárási rendünktől, de a beteg
gyógyulását eredményezte. Az eltávolított anyag szövettani vizsgálata derítette
ki a valódi kórokot, az emlőtumor körkörös és közel teljes elzáródást okozó
mediastinalis metastasisát. Orv Hetil. 2022; 163(24): 961–966.
Az epesavmérés szerepe a súlyos terhességi cholestasis szülészeti ellátásában
Authors: Deli Tamás , Tóth Judit , Csépes-Ruzicska Lea , Török Olga , Krasznai Zoárd Tibor , Mosolygó-Lukács Ágnes , Kappelmayer János , Lampé Rudolf
Published: November 2022

Bevezetés: A terhességi cholestasis a terhességek 1%-ában
előforduló kórkép. Fennállása nagymértékben növeli a súlyos magzati szövődmények
kialakulásának, így a koraszülésnek és a terminusközelben váratlanul
bekövetkező, méhen belüli magzati elhalásnak a rizikóját.
Célkitűzés: A hazánkban a klinikum számára a közelmúltban
elérhetővé vált szérumösszepesavszint-méréssel kapcsolatos eddigi
tapasztalataink összegzése és a terhességi cholestasis ellátása debreceni
gyakorlatának bemutatása. Betegek és módszer: Retrospektív
esetsorozatban vizsgáltuk a debreceni Szülészeti és Nőgyógyászati Klinikán 2020.
szeptember és 2021. szeptember között kezelt súlyos cholestasisos várandósok
adatait. Meghatároztuk az epesav-, a májenzim- és a bilirubinszintek
statisztikai korrelációját is. Eredmények: 758 várandós 1258
szérummintájából történt epesav-meghatározás. 5 esetben (az összes eset 0,7%-a,
a cholestasisos esetek 6,4%-a) súlyos (epesav 40–99 μmol/l), 7 esetben (0,9%,
illetve 9,0%) igen súlyos (epesav ≥100 μmol/l) epepangás volt igazolható. A 12
súlyos cholestasisos várandós átlagéletkora 30,6 (21–43) év volt, közülük 7 volt
primigravida. A betegek közül 5-nél állt fenn cholestasisra hajlamosító
előzményi betegség. 6 beteg részesült urzodezoxikólsav-kezelésben, amely az
epesavszintek jelentős csökkenését eredményezte. Súlyos cholestasisban az
epesav–GOT (R2 = 0,14) és az epesav–GPT (R2 = 0,17)
korreláció gyengének bizonyult (n = 45). Az epesavszintek postpartum hamar
szignifikánsan javultak. A 12 beteg közül eddig 11 szült meg, és 13 újszülött
született, 2/12 volt ikerterhesség. Az átlagos gestatiós kor a szüléskor 37
(33–40) hét volt. 3/11 koraszülés történt (27%). A terminusközeli szülések közül
7/8 (88%) szülésindukciót követően zajlott. Egyszer sem volt szükség elektív
császármetszésre, és a vajúdás során mindössze 2/11 esetben kellett
császármetszést végezni (18%). Intrauterin magzati elhalás nem következett be.
Következtetés: A szérumepesav-mérés hatékony eszköz a
terhességi cholestasis diagnosztikájában és követésében, a protokollalapú
szülészeti ellátáshoz pedig nélkülözhetetlen. A közleményben bemutatjuk
klinikánk epesavszinten alapuló terhességi cholestasis ellátásának gyakorlatát
is. Orv Hetil. 2022; 163(20): 797–805.
Csípőízületi protézisműtéten átesett betegek szociodemográfiai jellemzőinek és rövid távú életminőségének vizsgálata
Authors: Kajos Luca Fanni , Molics Bálint , Than Péter , Gőbel Gyula , Boncz Imre
Published: November 2022

Bevezetés: Az idősödő társadalomhoz kapcsolódó egészségügyi
szükségletek közül kiemelkedik a csípőprotézis-műtétek számának emelkedése.
Célkitűzés: Kutatásunk célja a különböző feltárásokban
végzett csípőízületi endoprotetizált betegek szociodemográfiai adatainak
vizsgálata, valamint a műtét előtti és a műtétet követő életminőség
összehasonlítása az állami és a magánegészségügy tekintetében. Adatok és
módszerek: Vizsgálatunk mintáját a Pécsi Tudományegyetem Klinikai
Központja Ortopédiai Klinikájának és a pécsi Da Vinci Magánklinikának a
csípőprotetizált betegei közül választottuk ki egyszerű, kényelmi mintavételi
technikával. A kérdőíves felmérés a műtét előtt és 6 héttel a műtét után került
lebonyolításra. A kérdőív kitért a résztvevők szociodemográfiai adataira, a
betegség és a műtét körülményeire, továbbá tartalmazott két nemzetközi kérdőívet
(SF-36, Oxford Hip Score). Eredmények: A kutatásban 164 fő vett
részt, 75 fő az állami egészségügy és 89 fő a magánegészségügy betegeként. Az
állami egészségügy betegeinek körében szignifikánsan magasabb volt a falusi
lakosok aránya (p = 0,014), míg a magánegészségügyben a nagyvárosi pácienseké.
Az állami betegek esetében magasabb volt az alapfokú (p<0,001) és a középfokú
(p = 0,042), míg a magánbetegeknél a felsőfokú (p<0,001) iskolai
végzettséggel rendelkezők aránya. Az állami betegek között nagyobb volt a
nyugdíjasok (p = 0,005), a magánegészségügyben pedig a szellemi munkások és a
saját vállalkozással rendelkezők aránya (p<0,001). 6 hét után mindkét csoport
életminősége szignifikáns javulást mutatott (p<0,001).
Következtetés: Az állami és a magánegészségügy betegeinek
szociodemográfiai jellemzői jelentősen különböznek, ám 6 héttel a
csípőprotézis-műtét után mindkét csoport életminősége szignifikáns javulást
mutatott. Orv Hetil. 2022; 163(26): 1037–1046.
E-páciensek Magyarországon: Digitális egészséggel kapcsolatos ismeretek, szokások egy országos reprezentatív felmérés tükrében
Authors: Girasek Edmond , Boros Julianna , Döbrössy Bence , Susánszky Anna , Győrffy Zsuzsa
Published: November 2022

Bevezetés: A digitalizáció egészségügyre gyakorolt hatása az
elmúlt évek egyik legfontosabb kutatási területévé vált. E folyamatot a
COVID–19-járvány is jelentősen katalizálta. Célkitűzés:
Országosan reprezentatív, lakossági kutatásunkban (n = 1500) arra kerestünk
választ, hogy a magyarországi páciensek miként használják a digitális egészség
eszköztárát, milyen előnyöket, hátrányokat jelent ezeknek a technológiáknak a
bevezetése és alkalmazása, és hogyan alakítja át mindez az orvos-beteg
kapcsolatot. Módszer: Országos reprezentatív kérdőíves
felmérést végeztünk, telefonos megkereséssel (CATI), 1500 fő megkérdezésével. A
minta nem, kor, településtípus és iskolai végzettség tekintetében reprezentálja
Magyarország nagykorú lakosságát. Eredmények: A válaszadók
81,3%-a használja az internetet, a használók 87,6%-a – ez a teljes minta
71,2%-át jelenti – egészséggel, betegséggel kapcsolatban is. Az internetes
tájékozódás legfontosabb forrásai a weboldalak (76,3%) és a közösségi média
(47,3%). Az e-receptet és az online időpontfoglalást ismerik a páciensek közül a
legtöbben (92,6% és 85,2%), ugyanakkor a megkérdezettek közel fele kipróbálná a
távvizitet, és szívesen venné, ha orvosa ajánlana neki hiteles weboldalakat,
applikációkat és szenzorokat. Eredményeink azt mutatják, hogy a településtípus
hatása a digitális egészségüggyel kapcsolatos kérdésekben nem jelentős,
ugyanakkor az életkor, az iskolai végzettség és a nem hatása számottevő.
Következtetés: Országos, reprezentatív lakossági
felmérésünk adatai azt mutatják, hogy a digitális egészségügyi megoldások
használata már jelenleg is az ellátás integráns része, ugyanakkor nagymértékű
igény rajzolódik ki a további digitális lehetőségek irányában is. Orv Hetil.
2022; 163(29): 1159–1165.
Exploring the limits of Fe3+ solid solution in calcium hexaluminate
Authors: de la Iglesia P. G. , García-Moreno O. , Menéndez J. L. , Torrecillas R. , Marco J. F.
Published: November 2022

Calcium hexaluminate (CA6) forms a broad range of solid solutions by substitution of Al3+ with other cations such as, for example, Fe, Co, Mn, etc. Solid solutions of CA6 with magnetic ions have attracted interest because they allow designing the magnetic behavior depending on the composition of each solid solution. In this paper, we have studied materials pertaining to an area of the CaO–Al2O3–Fe2O3 ternary phase diagram that is potentially interesting, but which has not been too much explored so far. We report on various synthesis methods of calcium hexaluminate with iron in solid solution. The percentages of iron introduced have been varied in order to determine the maximum percentage of iron that can enter into solid solution in the calcium hexaluminate such that the materials obtained exhibit magnetic behavior.

Graphical Abstract

Exploring the limits of Fe3+ solid solution in calcium hexaluminate.
Nonbinary Czech language
Authors: Kolek Vít
Published: November 2022

As a morphologically rich Slavic language, Czech contains many possibilities for nonbinary language use. The broad aim of this article is to provide insights into existing and emerging nonbinary language strategies and the metadiscourses that surround them. After outlining the available means of gender-fair language, the analysis turns to possibilities for expressing nonbinarity, presenting emic insights regarding nonbinary community members’ own language use, choices, innovations and metalinguistic reflections, as well as wider out-group responses. Discourses coming from the nonbinary community draw attention to less understood connections of language, self-expression, authenticity and social perception, whereas outgroup discourses draw on broad views of what is ‘natural’ in language and society. Emerging voices suggest that despite the general absence of debates surrounding nonbinary language in Czech academia and public discourse, much is happening ‘underground’ in personal language use and community interactions, reflecting the ongoing negotiation of tensions between gender-normative structures and the range of feasible agentive practices used to subvert them.Cestina jako morfologicky bohaty slovansky jazyk nabizi mnoho moznosti pro nebinarni vyjadrovani. Sirsim cilem clanku je poskytnout vhled do vznikajicich i jiz existujicich jazykovych strategii a taktez do metadiskurzu, ktere je obklopuji. Po nastineni dostupnych prostredku genderove vyvazeneho jazyka se analyza zameruje na moznosti vyjadreni nebinarity a predstavuje emicke poznatky tykajici se vlastniho uzivani jazyka nebinarni komunitou, jejich volby, inovace a metajazykove reflexe, stejne jako sirsi reakce mimo komunitu. Diskurzy vychazejici z nebinarni komunity se venuji predevsim mene znamym souvislostem jazyka, sebevyjadreni, autenticity a socialni percepce, zatimco diskurzy pochazejici mimo tuto skupinu venuji pozornost predevsim sirsimu kontextu toho, co je a neni v jazyce a spolecnosti ,,prirozene". Objevujici se hlasy naznacuji, ze navzdory obecne absenci debat o nebinarnim jazyce v ceskem akademickem prostredi a verejnem diskurzu se toho hodne deje ,,pod povrchem", tj. v osobnim uzivani jazyka, v interakcich dane komunity, coz odrazi probihajici obrusovani hran mezi genderove normativnimi strukturami a skalou moznych agentivnich praktik k jejich prekonani.
La representación escultórica de la mujer hispanorromana en el «conventus Caesaraugustanus»: imagen y proyección
Authors: García-de-la-Barrera Luka
Published: November 2022

En el presente trabajo, abordaremos la representación iconográfica de la mujer hispanorromana en el conventus Caesaraugustanus a par tir de aquellos vestigios escultóricos hallados en el territorio. Con todo ello, analizaremos la iconografía femenina como una imagen y proyección de la mujer en los espacios públicos de las ciudades hispanorromanas, centrándonos en aquellas representaciones destinadas al culto imperial y religioso con el objeto de descodificar un conjunto de valores asociados a la imagen de la perfectissima femina.
A critical review on wireless power transfer systems using metamaterials
Authors: Pham Thanh Son , Bui Xuan Khuyen , Bui Son Tung , Le Thi Hong Hiep , Vu Dinh Lam
Published: November 2022

Recently, wireless power transfer (WPT) has been a topic of interest due to its attractive applications in modern life. Starting from Tesla’s idea about a century ago, WPT has developed tremendously and appeared in many of the most modern electronic devices. However, some WPT systems still have limitations such as short transmission distance, low transfer efficiency, and electromagnetic leakage. Magnetic metamaterial (MM) is a potential candidate that can overcome the above disadvantages of WPT. This paper is intended to present an overview of recent advances and research progress on WPT systems. Three classes of WPT consisting of short-range, mid-range, and long-range, will be analyzed in detail both in terms of fundamentals and applications. Especially, MM configurations can be used to enhance the near-field WPT efficiency and reduce the leakage of electromagnetic field will also be evaluated. This article is expected to provide a comprehensive review of the mechanism and applications as well as the future development of metamaterial-based WPT systems.