bluuebunny/crossref_metadata_2025 huggingface dataset:
Does Land Fragmentation Affect the Effectiveness of Fiscal Subsidies for Agriculture: Evidence from China
Authors: Zou Wei , Zhang Zhenlin , Yang Fei
Published: December 2023

Fiscal and land policies are important tools in developing agriculture in China. Understanding how agricultural subsidies and land fragmentation jointly affect agricultural Total Factor Productivity (TFP) is crucial for building a strong agricultural nation. This paper utilizes microdata from fixed observation points in rural China from 2003 to 2017 and employs panel bidirectional fixed-effect models and moderation-effect models to empirically analyze the impact of agricultural subsidies and land fragmentation on agricultural TFP. The research finds: (1) Agricultural subsidies positively affect agricultural TFP, while land fragmentation leads to decreased agricultural TFP. (2) Land fragmentation hinders the positive effects of agricultural subsidies on agricultural TFP. A 1% increase in land fragmentation could lead to approximately a 3% decrease in the enhancement effect of agricultural subsidies, with significant impacts on households in major grain-producing areas and those primarily engaged in agriculture. (3) There is no evidence that reforms in the “three agricultural subsidies” would alter the combined effect of agricultural subsidies and land fragmentation on agricultural TFP. The obstructive role of land fragmentation cannot be mitigated through the “three agricultural subsidies” reform. The study indicates that the incentivizing role of agricultural subsidies has not been fully realized, and land fragmentation remains a key bottleneck in agricultural development. Fiscal support for agriculture should be coupled with effective land reform policies for synergistic efforts.
Representation of a Post-Fire Flash-Flood Event Combining Meteorological Simulations, Remote Sensing, and Hydraulic Modeling
Authors: Alamanos Angelos , Papaioannou George , Varlas George , Markogianni Vassiliki , Papadopoulos Anastasios , Dimitriou Elias
Published: December 2023

Wildfires are an escalating global threat, jeopardizing ecosystems and human activities. Among the repercussions in the ecosystem services of burnt areas, there are altered hydrological processes, which increase the risks of flash floods. There is limited research addressing this issue in a comprehensive way, considering pre- and post-fire conditions to accurately represent flood events. To address this gap, we present a novel approach combining multiple methods and tools for an accurate representation of post-fire floods. The 2019 post-fire flood in Kineta, Central Greece is used as a study example to present our framework. We simulated the meteorological conditions that caused this flood using the atmospheric model WRF-ARW. The burn extent and severity and the flood extent were assessed through remote sensing techniques. The 2D HEC-RAS hydraulic–hydrodynamic model was then applied to represent the flood event, using the rain-on-grid technique. The findings underscore the influence of wildfires on flooding dynamics, highlighting the need for proactive measures to address the increasing risks. The integrated multidisciplinary approach used offers an improved understanding on post-fire flood responses, and also establishes a robust framework, transferable to other similar cases, contributing thus to enhanced flood protection actions in the face of escalating fire-related disasters.
Relative Clause Processing and Attachment Resolution across Languages: Tatar–Russian–English Trilinguals
Authors: Sokolova Marina Y. , Levandovski Mikhael
Published: December 2023

The study investigates psycholinguistic mechanisms of sentence parsing and ambiguity resolution by balanced Tatar–Russian bilinguals who learnt English as their additional language. We check the parser’s sensitivity to the selectional properties of the matrix verb and/or social conventions in processing and attachment resolution of ambiguous relative clauses (RCs). We chose English and Russian because they have a documented preference for low attachment (LA) and high attachment (HA), respectively, and Tatar, as we have found out in earlier work, has no attachment ambiguity. We conducted a self-paced reading task in English and Russian which returned 61% HA in Russian, 49% HA in English. It was followed by a pen-and-paper translation task. The translation post-test checked whether an attachment preference demonstrated in either English or Russian showed in RC translations into Tatar. The results return an 80% preference for LA in English–Tatar translations and 61% in Russian–Tatar translations. Both syntactic information and world knowledge influence online RC processing in Russian and English. Therefore, the multilingual parser incorporates information from multiple sources in either L1 or Ln processing. The parser may favor LA as a default parsing option while maintaining sensitivity to individual grammars (Russian), where this preference should be overridden.
In Vitro and In Vivo Antihyperglycemic Effects of New Metabiotics from Boletus edulis
Authors: Zanfirescu Anca , Avram Ionela , Gatea Florentina , Roșca Răzvan , Vamanu Emanuel
Published: December 2023

The increasing incidence of diabetes has prompted the need for new treatment strategies, including natural products that reduce glycemia values. This work examined the in vitro and in vivo antihyperglycemic effects of new metabiotics derived from Boletus edulis extracts. The metabiotics were obtained from 100% B. edulis, and two other products, CARDIO and GLYCEMIC, from Anoom Laboratories SRL, which contain other microbial species related to B. edulis. Our in vitro investigations (simulations of the microbiota of patients with type 2 diabetes (T2D)) demonstrated that B. edulis extracts modulate the microbiota, normalizing its pattern. The effects were further tested in vivo, employing a mouse model of T2D. The tested extracts decreased glycemia values compared to the control and modulated the microbiota. The metabiotics had positive effects on T2D in vitro and in vivo, suggesting their potential to alleviate diabetes-associated microbiota dysbiosis.
The Possible Use of Stable Carbon and Nitrogen Isotope Signal and Spectral Analysis to Identify Habitat Condition of Aquatic Plants
Authors: Pronin Eugeniusz
Published: December 2023

Many macrophyte species exhibit a high degree of plasticity, enabling them to thrive in various aquatic ecosystems. Identifying the growth conditions of individual aquatic plant species during research or specimen collection is not always possible. In many cases, the nature of the planned research does not necessitate recognizing environmental conditions. However, the scope of identifying the habitat parameters of the collections of submerged aquatic plant herbariums provides an opportunity for further research. This paper explores the possibilities of using isotopic signals of plants, supported by spectral analyses of powdered plant materials, to ascertain the environmental conditions from which the samples were collected. The results obtained from the stable carbon and nitrogen isotope compositions (δ13CORG and δ15NORG) and the analysis of spectral spectra via FTIR-ART (Fourier Transform Infrared Spectroscopy with Attenuated Total Reflectance) of plant material (Elodea canadensis Michx. species) collected from various habitat ecosystems, including rivers and both hard- and softwater lakes, exhibited significant distinctions between these habitats. Particularly high values of δ15NORG were recorded in the material from rivers. The stable carbon and nitrogen isotope compositions did not differentiate between the material collected from softwater and hardwater lakes. Nevertheless, when comparing the isotopic findings with the FTIR-ATR spectral analysis focused on identifying characteristic peaks associated with the presence of calcium carbonate, noticeable differences were observed in the presence and intensity of calcium carbonate peaks in the material. These differences were only evident when nondecarbonated plant material from hardwater lakes was used for the FTIR-ATR analysis. To the best of the author’s knowledge, the combination of methods applied in this study to identify the origin of E. canadensis from various freshwater environments is the first application of its kind that could enable the rapid identification of plant material origin. Such identification could prove useful in environmental, ecological, and paleoenvironmental research. The increased knowledge of macrophytes’ δ13CORG and δ15NORG values might also be essential in further tracking accelerated eutrophication based on aquatic vegetation’s isotopic signals. This might be important due to the assumption that the increased rate of eutrophication influences organic matter sedimentation in aquatic ecosystems, especially lakes.
Gas-Sensing Properties and Mechanisms of 3D Networks Composed of ZnO Tetrapod Micro-Nano Structures at Room Temperature
Authors: Hu Jinjiang , Ma Hong , Zhou Yang , Ma Liyong , Zhao Shuyin , Shi Shuzheng , Li Jirong , Chang Yongqin
Published: December 2023

Metal oxide semiconductors (MOSs) hold great promise for electronic devices such as gas sensors. The utilization of ZnO as a conductometric gas sensor material can be traced back to its early stages; however, its application has primarily been limited to high-temperature environments. A gas sensor based on highly porous and interconnected 3D networks of ZnO tetrapod (ZnO-T) micro-nano structures was fabricated via an easy chemical vapor deposition (CVD) method. Homemade instruments were utilized to evaluate the gas-sensing of the sample at room temperature. It exhibited good gas-sensing at room temperature, particularly with a response of up to 338.80% toward 1600 ppm ethanol, while also demonstrating remarkable repeatability, stability, and selectivity. Moreover, the unique gas-sensing properties of ZnO-T at room temperature can be reasonably explained by considering the effect of van der Waals forces in physical adsorption and the synergistic effect of carrier concentration and mobility. The aforementioned statement presents an opportunity for the advancement of gas sensors utilizing ZnO at room temperature.
Growth and Structural Characterization of h-LuMnO3 Thin Films Deposited by Direct MOCVD
Authors: Ait Bassou Abderrazzak , Fernandes Lisete , Fernandes José R. , Figueiras Fábio G. , Tavares Pedro B.
Published: December 2023

In this work, we investigated the MOCVD conditions to synthesize thin films with the hexagonal P63cm h-LuMnO3 phase as a potential low-band gap ferroelectric material. The main parameters investigated were the ratio of organometallic starting materials, substrate temperature, and annealing effect. Two different substrates were used in the study: fused silica (SiO2) glass and platinized silicon (Pt\Ti\SiO2\Si(100)). In order to investigate the thermodynamic stability and quality of the developed phases, a detailed analysis of the crystal structure, microstructure, morphology, and roughness of the films was performed by X-ray diffractometer, scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), Raman spectroscopy, and piezoelectric force microscopy (PFM). Molar compositions in the film within 0.93 < |Lu|/|Mn| < 1.33 were found to be suitable for obtaining a single-phase h-LuMnO3. The best films were obtained by depositions at 700 °C, followed by thermal treatments at 800 °C for long periods of up to 12 h. These films exhibited a highly crystalline hexagonal single phase with a relatively narrow direct band gap, around 1.5 eV, which is within the expected values for the h-LuMnO3 system.
Biomimetic Sol–Gel Chemistry to Tailor Structure, Properties, and Functionality of Bionanocomposites by Biopolymers and Cells
Authors: Shchipunov Yury
Published: December 2023

Biosilica, synthesized annually only by diatoms, is almost 1000 times more abundant than industrial silica. Biosilicification occurs at a high rate, although the concentration of silicic acid in natural waters is ~100 μM. It occurs in neutral aqueous solutions, at ambient temperature, and under the control of proteins that determine the formation of hierarchically organized structures. Using diatoms as an example, the fundamental differences between biosilicification and traditional sol–gel technology, which is performed with the addition of acid/alkali, organic solvents and heating, have been identified. The conditions are harsh for the biomaterial, as they cause protein denaturation and cell death. Numerous attempts are being made to bring sol–gel technology closer to biomineralization processes. Biomimetic synthesis must be conducted at physiological pH, room temperature, and without the addition of organic solvents. To date, significant progress has been made in approaching these requirements. The review presents a critical analysis of the approaches proposed to date for the silicification of biomacromolecules and cells, the formation of bionanocomposites with controlled structure, porosity, and functionality determined by the biomaterial. They demonstrated the broad capabilities and prospects of biomimetic methods for creating optical and photonic materials, adsorbents, catalysts and biocatalysts, sensors and biosensors, and biomaterials for biomedicine.
The Effect of Homogenization Heat Treatment on 316L Stainless Steel Cast Billet
Authors: Chu Hung-Yang , Shiue Ren-Kae , Cheng Sheng-Yuan
Published: December 2023

This investigation aims to analyze the effect of homogenization heat treatment at 1240 °C for 2 and 6 h on the hardness, distribution, morphology, and chemical composition of the δ-ferrite and sigma phases in 316L stainless steel cast billet. A field emission scanning electron microscope, combined with electron back-scattered diffraction, a field emission electron probe microanalyzer with a wavelength dispersive spectrometer, and a Vickers microhardness tester are applied to identify various phase evolutions in the cast billet. The morphology of the δ-ferrite and sigma phases in the austenite matrix of the 316L cast billet are strongly related to the subsequent hot and cold wire drawings. The homogenization heat treatment is expected to provide a driving force to form spheroid interdendritic δ-ferrite and to minimize the amount of the brittle sigma intermetallic compound in the austenite matrix. The homogenization heat treatment at 1240 °C effectively spheroidized all δ-ferrites into blunt ones in the cast billet. The transformation of δ-ferrite into sigma is dominated by temperature and cooling rate. The fast air cooling after homogenization between 1240 and 850 °C retards the precipitation of the sigma in the δ-ferrite. There are two δ-ferrite transformation mechanisms in this experiment. The direct transformation of the δ-ferrite into sigma is observed in the as-cast 316L stainless steel billet. In contrast, the eutectoid transformation of the δ-ferrite into the sigma and austenite dominates the 316L cast billet homogenized at 1240 °C, with a slow furnace cooling rate.
Investigation of a Low-Speed Commutation Voltage Shock Problem in Three-Level ANPC Inverter with Hybrid Modulation Mode
Authors: Yu Jian , Shen Renhui , Zhou Le , Jia Zelin , Hao Yulong
Published: December 2023

With the development of the photovoltaic industry; there will be an increasing demand for efficient, high-power density, and low-cost grid interface converters. Compared with two-level inverters, multilevel inverters have the following advantages: (1) lower device voltage ratings; (2) better output filtering spectrum; (3) lower electromagnetic interference (EMI) noise; and (4) higher switching speed capability. However, the complex switching circuit of the multilevel inverter will bring more parasitic inductance, resulting in severe switching overvoltage (ringing). Especially in order to reduce the cost of the inverter, using the long-loop modulation mode, the commutation loop will introduce more parasitic inductance, which will make the overvoltage more serious. Consider that commonly used overvoltage absorption schemes are effective only for overvoltage or suppression of oscillations. Therefore, a new overvoltage absorption circuit is proposed in this paper, which can not only alleviate the overvoltage and ringing phenomena but also suppress the effect of voltage jumps during low-frequency switching on high-frequency input voltage. This overvoltage absorption circuit is characterized by low overvoltage, fast ringing damping, and minimum capacitance. Experiments and simulations are conducted to verify the effectiveness of this overvoltage absorption circuit using a three-level ANPC inverter as a prototype. The results show that the proposed overvoltage absorption circuit can significantly reduce the overvoltage level, shorten the oscillation time, and reduce the voltage difference between the upper and lower DC bus capacitors.
University Campus as a Complex Pedestrian Dynamic Network: A Case Study of Walkability Patterns at Texas Tech University
Authors: Salkhi Khasraghi Gisou , Volchenkov Dimitri , Nejat Ali , Hernandez Rodolfo
Published: December 2023

Statistical mechanics of walks defined on the spatial graphs of the city of Lubbock (10,421 nodes) and the Texas Tech University (TTU) campus pedestrian network (1466 nodes) are used for evaluating structural isolation and the integration of graph nodes, assessing their accessibility and navigability in the graph, and predicting possible graph structural modifications driving the campus evolution. We present the betweenness and closeness maps of the campus, the first passage times to the different campus areas by isotropic and anisotropic random walks, as well as the first passage times under the conditions of traffic noise. We further show the isolation and integration indices of all areas on the campus, as well as their navigability and strive scores, and energy and fugacity scores. The TTU university campus, a large pedestrian zone located close to the historical city center of Lubbock, mediates between the historical city going downhill and its runaway sprawling body.
Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis
Authors: Nam Eun-Young , Choi Su Hyun , Hwang Ji Hye
Published: December 2023

Background and Objectives: Korean and traditional Chinese medicine state that pyrite is effective for fracture treatment, but supporting clinical data are limited. This systematic review aimed to investigate the therapeutic role of Chinese patent medicine containing pyrite (CPMP) in clinical treatment for fractures. Materials and Methods: Seven electronic databases were searched using the keywords “pyrite”, “pyritum”, and “zirantong” between inception and December 2022, yielding 29 published clinical studies. Randomized controlled trials that included CPMP were considered eligible regardless of the fracture type. Quality assessment and meta-analysis of the included RCTs were also performed. Results: Most studies showed high heterogeneity (I2 > 50%) and significant results (p < 0.05). Compared to the results of the control group, CPMP was more effective in terms of the primary outcome related to the efficacy rate, including the total effective rate, callus growth rate, bone union, and edema disappearance time (all p < 0.00001) and in terms of secondary outcomes related to pain reduction, namely pain intensity and pain disappearance time, than the control group (both p < 0.01). CPMP was more effective than the control group in terms of erythrocyte sedimentation rate (p < 0.01), hematocrit (p < 0.01), erythrocyte aggregation (p < 0.05), and plasma viscosity (p < 0.05). CPMP did not cause serious side effects, and the incidence of complications was significantly less than that in the control group. Conclusions: CPMP may be a safe and effective alternative treatment for fractures and may be beneficial in preventing postoperative complications, reducing pain, relieving symptoms, and accelerating healing.
Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood
Authors: Reiss Allison B. , Gulkarov Shelly , Pinkhasov Aaron , Sheehan Katie M. , Srivastava Ankita , De Leon Joshua , Katz Aaron E.
Published: December 2023

Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer’s disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes, illustrating common ground for the mechanistic underpinning of the symptomatology. The purpose of this review was to investigate the effects of ADT on cognitive function, mood, and quality of life, as well as to analyze the relationship between ADT and Alzheimer’s disease. The evaluation of prostate cancer patient cognitive ability via neurocognitive testing is described. Future studies should further explore the connection among cognitive deficits, mood disturbances, and the physiological changes that occur when hormonal balance is altered.
Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells
Authors: Turkez Hasan , Arslan Mehmet Enes , Selvitopi Harun , Kadi Abdurrahim , Oner Sena , Mardinoglu Adil
Published: December 2023

Background and Objectives: Favipiravir (FPV) is an antiviral medication and has an inhibitory effect on Cytochrome P450 (CYP2C8) protein, which is mainly involved in drug metabolism in the liver, and the expression of this gene is known to be enhanced in neuronal cells. The metabolization of Paclitaxel (PTX), a chemotherapeutic drug used in cancer patients, was analyzed for the first time in the human SH-SY5Y neuroblastoma cell line for monitoring possible synergistic effects when administered with FPV. Materials and Methods: Further, in vitro cytotoxic and genotoxic evaluations of FPV and PTX were also performed using wide concentration ranges in a human fibroblast cell culture (HDFa). Nuclear abnormalities were examined under a fluorescent microscope using the Hoechst 33258 fluorescent staining technique. In addition, the synergistic effects of these two drugs on cultured SH-SY5Y cells were determined by MTT cell viability assay. In addition, the death mechanisms that can occur in SHSY-5Y were revealed by using the flow cytometry technique. Results: Cell viability analyses on the HDFa healthy cell culture showed that both FPV and PTX have inhibitory effects at higher concentrations. On the other hand, there were no significant differences in nuclear abnormality numbers when both of the compounds were applied together. Cell viability analyses showed that FPV and PTX applications have higher cytotoxicity, which indicated synergistic toxicity against the SHSY-5Y cell line. Also, PTX exhibited higher anticancer properties against the neuroblastoma cell line when applied with FPV, as shown in both cytotoxicity and flow cytometry analyses. Conclusions: In light of our findings, the anticancer properties of PTX can be enhanced when the drug application is coupled with FPV exposure. Moreover, these results put forth that the anticancer drug dosage should be evaluated carefully in cancer patients who take COVID-19 treatment with FPV.
Effect of Milling Strategy on the Surface Quality of AISI P20 Mold Steel
Authors: Abbas Adel T. , Abdelnasser Elshaimaa , Naeim Noha , Alqosaibi Khalid F. , Al-Bahkali Essam A. , Elkaseer Ahmed
Published: December 2023

This paper explores the impact of various milling strategies, including up-milling, down-milling, and hybrid approaches, on the surface roughness of AISI P20 mold steel. The study is methodically divided into three stages to comprehensively understand the effects of these strategies. The first stage involves milling single slots with varying cutting parameters to establish baseline effects. The second stage examines the effects of consistent milling strategies (up-up and down-down) on surface quality. The third stage probes into hybrid strategies (up-down and down-up) to assess their effectiveness. Central to this investigation is not only the type of milling strategy but also how cutting speed and feed rate influence the resultant surface roughness. Our findings indicate that up-milling generally leads to a 22% increase in surface roughness compared to down-milling. This trend is visually verified by surface texture analyses. When comparing consistent strategies, up-up milling tends to produce rougher surfaces than down-down milling by approximately 25%, characterized by distinctive scratches and feed mark overlays. Remarkably, while the hybrid milling strategies do not exhibit significant differences in surface roughness, variations in cutting speed and feed rate play a crucial role. Specifically, at lower speeds, hybrid milling achieves smoother surfaces than the identical double milling mode, while at a cutting speed of 100 m/min, the double mode demonstrates a notable decrease in roughness. Additionally, this study introduces a color mapping simulation for machined pockets, validated by experimental results, to predict surface roughness based on the strategic history of milling, thereby offering valuable insights for optimizing milling processes.
Predictive Modeling of Hardness Values and Phase Fraction Percentages in Micro-Alloyed Steel during Heat Treatment Using AI
Authors: Bassi Ankur , Bodas Soham Tushar , Hasan Syed Shuja , Sidhu Gaganpreet , Srinivasan Seshasai
Published: December 2023

In this work, we have proposed an AI-based model that can simultaneously predict the hardness and phase fraction percentages of micro-alloyed steel with a predefined chemical composition and thermomechanical processing conditions. Specifically, the model uses a feed-forward neural network enhanced by the ensemble method. The model has been trained on experimental data derived from continuous cooling transformation (CCT) diagrams of 39 different steels. The inputs to the model include a cooling profile defined by a set of time-temperature values and the chemical composition of the steel. Sensitivity analysis was performed on the validated model to understand the impact of key input variables, including individual alloys and the thermomechanical processing conditions. This analysis, which measures the variability in output in response to changes in a specific input variable, showed excellent agreement with experimental data and the trends in the literature. Thus, our model not only predicts steel properties under varied cooling conditions but also aligns with existing theoretical knowledge and experimental data.
Microstructural Evolution of High-Entropy Intermetallic Compounds during Detonation Spraying
Authors: Ostovari Moghaddam Ahmad , Sudarikov Mikhail , Shaburova Nataliya , Polyakova Marina , Samodurova Marina , Trofimov Evgeny
Published: December 2023

This study aims at investigating the feasibility of depositing quality coatings from various high-entropy intermetallic compounds (HEICs) using detonation spraying (DS). Four different HEIC coatings, namely (NbTaVCrTi)Al3, (NbTaVNiFe)Al3, (NbTaVZrHf)Al3, and (FeNiCoCrMn)(MoCr), were prepared by DS on low alloy steel substrates. The HEIC powders were first prepared by arc melting followed by ball milling and then used as reinforcement particles to deposit HEIC coatings. Elemental segregation was observed for all the as-cast samples. Powders with average particle sizes of about ~25 µm for (NbTaVCrTi)Al3, ~22 µm for (NbTaVNiFe)Al3, ~34 µm for (NbTaVZrHf)Al3, and ~18 µm for (FeNiCoCrMn)(MoCr) were obtained. (NbTaVCrTi)Al3, (NbTaVNiFe)Al3, and (NbTaVZrHf)Al3 HEICs exhibited a nearly single D022 (TaAl3 type) structure, while (FeNiCoCrMn)(MoCr) exhibited a single D8b (FeCr type) structure. Dense coatings consisted of a lamellar microstructure and sound bonding with the substrate, and low porosity was obtained for all the samples. Crystal structures of the HEIC samples were highly retained during DS, whereas all the samples underwent some degree of oxidation. Microhardness values of 745 HV for (NbTaVCrTi)Al3, 753 HV for (NbTaVNiFe)Al3, and 862 HV for (NbTaVZrHf)Al3 were obtained, which are significantly higher than the microhardness of the substrate (~140 HV). Among all the samples, (FeNiCoCrMn)(MoCr) exhibited the highest microhardness values of about 1047 HV.
Parent Grain Reconstruction in an Additive Manufactured Titanium Alloy
Authors: Wright Stuart I. , Lenthe William C. , Nowell Matthew M.
Published: December 2023

Electron backscatter diffraction (EBSD) is an excellent tool for characterizing the crystallographic orientation aspects of the microstructure of polycrystalline material. In some additively manufactured materials, the material may undergo a phase transformation during the forming process. Although EBSD can only characterize the final microstructure, neighbor information from orientation mapping allows the microstructure before the phase transformation to be reconstructed, provided that the parent–child orientation relationship is known. An investigation of the effectiveness of the reconstruction algorithms for capturing the grain size as well as orientation gradients is undertaken with a focus on additively manufactured Ti-alloy. The EBSD results, coupled with reconstruction algorithms, reveal information on the prior grain size as well as the plastic flow of the material.
Deformation–Induced Mechanical Synthesis of U and Fe
Authors: Kozlov Kirill , Shabashov Valery , Kataeva Natalya , Sagaradze Victor , Pilyugin Vitalii , Zamatovskii Andrey
Published: December 2023

The phase composition of metallic α-U and Fe after mechanical synthesis in conditions of severe (mega) plastic deformation at room temperature using rotational Bridgman anvils was studied using Mössbauer spectroscopy, scanning and transmission electron microscopy. It was shown that mechanical synthesis results in U6Fe and UFe2 intermetallic formation with a precursor represented by UFe2(D) and UFe3(D) defective phases and a defective dispersed mechanical mixture of iron and uranium. Low-level annealing at 300 °C results in the ordering of the defective phases and transition of a dispersed mechanical mixture of iron and uranium into U6Fe and UFe2 intermetallics. The diffusion mechanism of intermetallic formation in conditions of cold deformation of iron and uranium mixture was established, and the high deformation and thermal phase stability of intermetallics U6Fe and UFe2 was shown.
Integration of Riboflavin-Modified Carbon Fiber Mesh Electrode Systems in a 3D-Printed Catheter Hub
Authors: Casimero Charnete , Smith Robert B. , Davis James
Published: December 2023

Background: Catheter line infection is a common complication within clinical environments, and there is a pressing need for technological options to aid in reducing the possibility of sepsis. The early identification of contamination could be pivotal in reducing cases and improving outcomes. Method: A sensing rationale based on a riboflavin-modified electrode system integrated within a modified 3D-printed catheter needle-free connector is proposed, which can monitor changes in pH brought about by bacterial contamination. Results: Riboflavin, vitamin B2, is a biocompatible chemical that possesses a redox-active flavin core that is pH dependent. The oxidation peak potential of the adsorbed riboflavin responds linearly to changes in pH with a near-Nernstian behavior of 63 mV/pH unit and is capable of accurately monitoring the pH of an authentic IV infusate. Conclusions: The proof of principle is demonstrated with an electrode-printed hub design offering a valuable foundation from which to explore bacterial interactions within the catheter lumen with the potential of providing an early warning of contamination.
Improvement of AlGaN/GaN High-Electron-Mobility Transistor Radio Frequency Performance Using Ohmic Etching Patterns for Ka-Band Applications
Authors: Lee Ming-Wen , Chuang Cheng-Wei , Gamiz Francisco , Chang Edward-Yi , Lin Yueh-Chin
Published: December 2023

In this paper, AlGaN/GaN high-electron-mobility transistors (HEMTs) with ohmic etching patterns (OEPs) “fabricated to improve device radio frequency (RF) performance for Ka-band applications” are reported. The fabricated AlGaN/GaN HEMTs with OEP structures were used to reduce the source and drain resistances (Rs and Rd) for RF performance improvements. Within the proposed study using 1 μm hole, 3 μm hole, 1 μm line, and 3 μm line OEP HEMTs with 2 × 25 μm gate widths, the small signal performance, large signal performance, and minimum noise figure (NFmin) with optimized values were measured for 1 μm line OEP HEMTs. The cut-off frequency (fT) and maximum oscillation frequency (fmax) value of the 1 μm line OEP device exhibited optimized values of 36.4 GHz and 158.29 GHz, respectively. The load–pull results show that the 1 μm line OEP HEMTs exhibited an optimized maximum output power density (Pout, max) of 1.94 W/mm at 28 GHz. The 1 μm line OEP HEMTs also exhibited an optimized NFmin of 1.75 dB at 28 GHz. The increase in the contact area between the ohmic metal and the AlGaN barrier layer was used to reduce the contact resistance of the OEP HEMTs, and the results show that the 1 μm line OEP HEMT could be fabricated, producing the best improvement in RF performance for Ka-band applications.
Logical Resolving-Based Methodology for Efficient Reliability Analysis
Authors: Tang Zhengguang , Li Cong , You Hailong , Liu Xingming , Wang Yu , Dai Yong , Bai Geng , Lin Xiaoling
Published: December 2023

With the CMOS technology downscaling to the deep nanoscale, the aging effects of devices degrade circuit performance and even lead to functional failure. The stress analysis is critical to evaluate the influence of aging effects on digital circuits. Some related analytical work has recently focused on reliability-aware circuit analysis. Nevertheless, the aging dependence among different devices is not considered, which will induce errors of degradation evaluation in the digital circuit. In order to improve the accuracy of reliability-aware static timing analysis, an improved analytical method is proposed by employing logical resolving. Experimental results show that the proposed method has a better evaluation accuracy of aging path delay than traditional strategies. For aging timing evaluation on aging paths, excessive pessimism can be reduced by employing the proposed method. And, a 378× speedup is achieved while having a 0.56% relative error compared with precise SPICE simulation. Moreover, the circuit performance sacrifice of an aging-aware synthesis flow with the proposed method can be decreased. Due to the high efficiency and high accuracy, the proposed method can meet the speed demands of large-scale digital circuit reliability analysis while achieving transistor simulation accuracy.
Application of Braided Piezoelectric Poly-l-Lactic Acid Cord Sensor to Sleep Bruxism Detection System with Less Physical or Mental Stress
Authors: Tajitsu Yoshiro , Shimda Saki , Nonomura Takuto , Yanagimoto Hiroki , Nakamura Shun , Ueshima Ryoma , Kawanobe Miyu , Nakiri Takuo , Takarada Jun , Takeuchi Osamu , Nisho Rei , Takeshita Koji , Takahashi Mitsuru , Sugiyama Kazuki
Published: December 2023

For many years, we have been developing flexible sensors made of braided piezoelectric poly-l-lactic acid (PLLA) fibers that can be tied and untied for practical applications in society. To ensure good quality of sleep, the occurrence of bruxism has been attracting attention in recent years. Currently, there is a need for a system that can easily and accurately measure the frequency of bruxism at home. Therefore, taking advantage of the braided piezoelectric PLLA cord sensor’s unique characteristic of being sewable, we aimed to provide a system that can measure the frequency of bruxism using the braided piezoelectric PLLA cord sensor simply sewn onto a bed sheet on which the subject lies down. After many tests using trial and error, the sheet sensor was completed with zigzag stitching. Twenty subjects slept overnight in a hospital room on sheets integrated with a braided piezoelectric PLLA cord. Polysomnography (PSG) was simultaneously performed on these subjects. The results showed that their bruxism could be detected with an accuracy of more than 95% compared with PSG measurements, which can only be performed in a hospital by a physician and are more burdensome for the subjects, with the subjects simply lying on the bed sheet with a braided piezoelectric PLLA cord sensor sewn into it.
Inert-Atmosphere Microfabrication Technology for 2D Materials and Heterostructures
Authors: Duleba Aliaksandr , Pugachev Mikhail , Blumenau Mark , Martanov Sergey , Naumov Mark , Shupletsov Aleksey , Kuntsevich Aleksandr
Published: December 2023

Most 2D materials are unstable under ambient conditions. Assembly of van der Waals heterostructures in the inert atmosphere of the glove box with ex situ lithography partially solves the problem of device fabrication out of unstable materials. In our paper, we demonstrate an approach to the next-generation inert-atmosphere (nitrogen, <20 ppm oxygen content) fabrication setup, including optical contact mask lithography with a 2 μm resolution, metal evaporation, lift-off and placement of the sample to the cryostat for electric measurements in the same inert atmosphere environment. We consider basic construction principles, budget considerations, and showcase the fabrication and subsequent degradation of black-phosphorous-based structures within weeks. The proposed solutions are surprisingly compact and inexpensive, making them feasible for implementation in numerous 2D materials laboratories.
Influence of Source Materials, Concentration, Gastric Digestion, and Encapsulation on the Bioactive Response of Brassicaceae-Derived Samples against Helicobacter pylori
Authors: Garcia-Ibañez Paula , Silvan Jose Manuel , Moreno Diego A. , Carvajal Micaela , Martinez-Rodriguez Adolfo J.
Published: December 2023

Isothiocyanates may have antibacterial activity against Helicobacter pylori, but there are different variables related to Brassicaceae-derived samples that could affect their efficacy. This work studied the influence of source variety, concentration, gastric digestion, and encapsulation of samples on their bioactive response against Helicobacter pylori. The antibacterial activity of raw sprouts (red cabbage and red radish) showed the highest antibacterial effect, which was consistent with a higher amount of isothiocyanates. It decreased with gastric digestion, regardless of sample encapsulation. By contrast, adult red radish leaves became antibacterial after gastric digestion. Antioxidant activity on H. pylori-infected gastric cells was similar in all samples and followed an equivalent pattern with the changes in isothiocyanates. Raw samples decreased intracellular reactive oxygen species production, but they lost this capacity after gastric digestion, regardless whether the compounds were free or encapsulated. Red cabbage sprouts, red radish sprouts, and red radish roots produced a decrease in nitric oxide production. It was consistent with a modulation of the inflammatory response and was associated to isothiocyanates concentration. Encapsulated sprout samples retained part of their anti-inflammatory activity after gastric digestion. Adult raw red radish leaves were not active, but after digestion, they became anti-inflammatory. The results obtained in this study have shown that several variables could have a significant impact on the bioactive properties of Brassicaceae-derived samples against H. pylori, providing a starting point for the design and standardization of samples with specific bioactivities (antibacterial, antioxidant, and anti-inflammatory) potentially useful for the treatment of H. pylori infection.
Mineralogical Characteristics and Genetic Types of Pyrite with Different Occurrence: Constraints from Spectroscopy, Geochemistry and δ34S Stable Isotopes
Authors: Ma Shiyu , Shi Miao , Zhang Cun , Cao Qinyuan
Published: December 2023

Pyrite is widely distributed in the Earth’s crust and oceanic systems, and it generally occurs as pentagonal dodecahedra, cubic, octahedral, idiomorphic crystals, or dense, massive, granular, and nodular aggregates. In this study, representative pyrite samples from Hunan, Fujian, Jiangxi, Anhui in China and from Peru were collected. By utilizing a range of analytical techniques, including petrography, X-ray diffraction, infrared spectrum, Raman spectrum, major and trace element analysis, as well as sulfur stable isotope analysis, we comprehensively depict the mineralogical and spectroscopic characteristics of pyrite, and the evolution processes of the physical and chemical conditions of mineralization can be qualitatively constrained. The spectroscopic results indicate all samples show a relatively narrow absorption band with weak to moderate intensity in the vicinity of 343 cm−1, which represents the bending vibration of the Fe-[S2]2− molecular bond. The Co content of pyrite exhibits the characteristics of a positive correlation with temperature and a negative correlation with oxygen fugacity, respectively. The δ34S isotopic compositions of colloidal pyrite are in the range of 0.03 to 0.67, which are close to meteoric sulfur and mantle sulfur compositions, while the δ34S values of nodular pyrite fall within the range of granite, indicating the characteristics of mixtures of sulfur sources are mainly related to magmatic activity. Our results provide insight into the formation mechanisms of pyrite in different environments, its mineralization, and the ore genesis of deposits. Moreover, the integrated analytical methods for pyrite are provided, which can define theoretical guidance for the exploration and development of mineral resources.
The Occurrence and Chemical Composition of Bismuth-Bearing Minerals in the Niuxingba-Liumukeng Ag-Pb-Zn Deposit, Jiangxi Province, South China
Authors: Yue Qiuyu , Zhai Degao , Zhao Gang , Zhao Qingqing , Liu Jiajun
Published: December 2023

The Niuxingba-Liumukeng deposit, located in the Yinkeng ore field (Jiangxi province, South China), is a typical Ag-Pb-Zn deposit hosted in the Yudu-Ganxian metallogenic belt. Based on the field investigation and mineralogical studies, the mineralization of this deposit can be divided into three stages: quartz-pyrite-arsenopyrite stage (I), quartz-galena-sphalerite-sulfosalt stage (II), and quartz-carbonate stage (III), with stage II being the main Ag mineralization stage. In this contribution, we reported the occurrence of bismuth-bearing minerals in this hydrothermal deposit and its implications for ore formation. Based on the results of electron microprobe analyses, we infer that the dominant occurrence of bismuth at Niuxingba-Liumukeng is primarily marked by solid solutions within the crystal lattice of galena and as visible independent bismuth-bearing minerals. The independent bismuth minerals consist of berryite [Pb3(Ag,Cu)5Bi7S16], emplectite (CuBiS2), and aikinite (PbCuBiS3). Most bismuth minerals replace chalcopyrite or fill in the cracks of pyrite and chalcopyrite. Meanwhile, we found a large number of Bi-bearing minerals closely coexisting with Ag-bearing minerals, indicating that bismuth may have played a crucial role in silver deposition from hydrothermal fluids. We considered that the existence of bismuth-rich melts associated with the ore-forming hydrothermal systems could help to promote the enrichment and precipitation of silver to form economic ores.
Evaluation of Anti-Trypanosoma cruzi Activity of Chemical Constituents from Baccharis sphenophylla Isolated Using High-Performance Countercurrent Chromatography
Authors: Silva Matheus L. , Sales Felipe S. , Levatti Erica V. C. , Antar Guilherme M. , Tempone Andre G. , Lago João Henrique G. , Jerz Gerold
Published: December 2023

Endemic in 21 countries, Chagas disease, also known as American Trypanosomiasis, is a neglected tropical disease (NTD) caused by the protozoan parasite Trypanosoma cruzi. The available drugs for the treatment of this disease, benznidazole and nifurtimox, are outdated and display severe side effects. Thus, the discovery of new drugs is crucial. Based on our continuous studies aiming towards the discovery of natural products with anti-T. cruzi potential, the MeOH extract from aerial parts of Baccharis sphenophylla Dusén ex. Malme (Asteraceae) displayed activity against this parasite and was subjected to high-performance countercurrent chromatography (HPCCC), to obtain one unreported syn-labdane diterpene — sphenophyllol (1) — as well as the known compounds gaudichaudol C (2), ent-kaurenoic acid (3), hispidulin (4), eupafolin (5), and one mixture of di-O-caffeoylquinic acids (6–8). Compounds 1–8 were characterized by analysis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. When tested against trypomastigote forms, isolated labdane diterpenes 1 and 2 displayed potent activity, with EC50 values of 20.1 μM and 2.9 μM, respectively. The mixture of chlorogenic acids 6–8, as well as the isolated flavones 4 and 5, showed significant activity against the clinically relevant amastigotes, with EC50 values of 24.9, 12.8, and 2.7 μM, respectively. Nonetheless, tested compounds 1–8 displayed no cytotoxicity against mammalian cells (CC50 > 200 μM). These results demonstrate the application of HPCCC as an important tool to isolate bioactive compounds from natural sources, including the antitrypanosomal extract from B. sphenophylla, allowing for the development of novel strategic molecular prototypes against tropical neglected diseases.
Anticholinesterase and Antityrosinase Secondary Metabolites from the Fungus Xylobolus subpileatus
Authors: Felegyi Kristóf , Garádi Zsófia , Studzińska-Sroka Elżbieta , Papp Viktor , Boldizsár Imre , Dancsó András , Béni Szabolcs , Zalewski Przemysław , Ványolós Attila
Published: December 2023

Xylobolus subpileatus is a widely distributed crust fungus reported from all continents except Antarctica, although considered a rare species in several European countries. Profound mycochemical analysis of the methanol extract of X. subpileatus resulted in the isolation of seven compounds (1–7). Among them, (3β,22E)-3-methoxy-ergosta-4,6,814,22-tetraene (1) is a new natural product, while the NMR assignment of its already known epimer (2) has been revised. In addition to a benzohydrofuran derivative fomannoxin (3), four ergostane-type triterpenes 4–7 were identified. The structure elucidation of the isolated metabolites was performed by one- and two-dimensional NMR and MS analysis. Compounds 2–7 as well as the chloroform, n-hexane, and methanol extracts of X. subpileatus were evaluated for their tyrosinase, acetylcholinesterase, and butyrylcholinesterase inhibitory properties. Among the examined compounds, only fomannoxin (3) displayed the antityrosinase property with 51% of inhibition, and the fungal steroids proved to be inactive. Regarding the potential acetylcholinesterase (AChE) inhibitory activity of the fungal extracts and metabolites, it was demonstrated that the chloroform extract and compounds 3–4 exerted noteworthy inhibitory activity, with 83.86 and 32.99%, respectively. The butyrylcholinesterase (BChE) inhibitory assay revealed that methanol and chloroform extracts, as well as compounds 3 and 4, exerted notable activity, while the rest of the compounds proved to be only weak enzyme inhibitors. Our study represents the first report on the chemical profile of basidiome of the wild-growing X. subpileatus, offering a thorough study on the isolation and structure determination of the most characteristic biologically active constituents of this species.