bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Implementasi Matriks dalam Estimasi Laju Pertumbuhan Populasi Wanita
Authors: Wijaya Ulfia Imelda , Nisfulaila Intan
Published: January 2024

Leslie matrix is a growth matrix used to estimate the growth rate of a population. Through the population growth rate, information can be obtained whether the growth tends to increase, decrease, or stabilize. The general form of the Leslie matrix is a square matrix in which the first-row entries contain values of female fertility rate , the subdiagonals contain values of female survival rate , and entries other than in the first row and sub diagonals are zero. This research is to determine the implementation of the Leslie matrix in estimating the female population growth rate in Situbondo Regency 2023 and its analysis. The stages of this research began with presenting the Leslie matrix population growth model for the next three years. The second stage is to determine the age class interval. Next, determine the initial age distribution vector. The fourth and fifth stages, respectively, are calculating the  and the  value. The next step is constructing the Leslie matrix. The seventh stage is to calculate the estimated female population. The eighth stage is determining the eigenvalue and ends with determining the dominant eigenvalue. Based on the results of the research that has been done, it is obtained that the estimated female population in Situbondo Regency 2023 tends to decrease with the acquisition of a dominant eigenvalue that is less than one. That information can be taken into consideration by the government in formulating population-related policies.
Daidzein- A Caveolin Inhibitor Exerts Antihypertensive Effect and Improves Endothelium-Dependent Vasorelaxation in a Rat Model of DOCA-Salt-Induced Hypertension
Authors: Jamwal Shalini
Published: January 2024

Daidzein- A caveolin inhibitor has antioxidant properties that could improve redox-sensitive vascular, cardiac and renal changes associated with deoxycorticosterone acetate/1% NaCl high salt (DOCA/HS)-induced hypertension. We investigated the possible involvement of caveolin and daidzein its inhibitor in hypertension and endothelial dysfunction in a mineralocorticoid-salt mouse model (DOCA-Salt). Hypertension was induced in sham control mice by nephrectomy and deoxycorticosterone acetate (DOCA)-salt treatment for 6-weeks. (Control uninephrectomized mice drank 1% NaCl water). Nephrectomy + DOCA (40mg/kg, s.c: 6 weeks) administration increased mean arterial blood pressure in rats after 6 weeks as compared to normal control group. VED was assessed in terms of decreased serum nitrite/nitrate conc., reduced glutathione levels, ACh-induced endothelium-dependent vasorelaxation, and SNP-induced endothelium-independent Vasorelaxation. These rats received cotreatment of different doses of daidzein (0.2, 0.4mg/kg/day, sac) for 5 weeks. Daidzein (0.2mg/kg/day., and 0.4 mg/kg/day., sac for 1 week) and lisinopril 1mg/kg., p.o., 1 week) treatment for one week significantly ameliorated VED in hypertensive rats measured in terms of decreased reduced glutathione level, serum nitrite/nitrate conc. increased Ach-induced endothelium-dependent vasorelaxation as compared to the hypertensive group. However, sodium nitroprusside did not produce any change in SNP-induced endothelium-independent vasorelaxation that shows that effect is specifically due to the improvement of endothelium dysfunction. Our results demonstrate that daidzein reduces oxidative stress, prevents development and progression of hypertension as well as cardiac and renal hypertrophy in DOCA/HS-induced hypertension via modulation of activated eNOS, endogenous antioxidants, serum NO.
Integrasi Nilai-Nilai Islami dalam Praktik Kepemimpinan Pendidikan: Membangun Lingkungan Pembelajaran yang Berdaya Saing
Authors: Shofiyyah Nilna Azizatus , Komarudin Tedy Sutandy , Ulum Miftahul
Published: January 2024

Penelitian ini menganalisis integrasi nilai-nilai Islami dalam praktik kepemimpinan pendidikan dan dampaknya terhadap lingkungan pembelajaran yang berdaya saing. Metode kualitatif dengan pendekatan studi literatur digunakan. Tujuannya adalah memahami bagaimana pemimpin pendidikan mengintegrasikan nilai-nilai Islami dalam praktik kepemimpinan dan dampaknya pada lingkungan pembelajaran. Hasilnya menunjukkan bahwa integrasi nilai-nilai Islami menciptakan lingkungan pembelajaran yang holistik, mengembangkan moralitas, etika, dan kepedulian sosial siswa. Pemimpin pendidikan yang mengintegrasikan nilai-nilai Islami menjadi teladan inspiratif dan memperkuat ikatan dengan pengalaman sehari-hari siswa. Ini juga membantu menciptakan budaya sekolah inklusif dan mendorong kerjasama antar siswa. Implikasinya memberi pemahaman tentang pentingnya integrasi nilai-nilai Islami dalam kepemimpinan Pendidikan.
Educación y Tecnología: Mitos y ambigüedades en tiempos de crisis
Authors: JIMÉNEZ-HERRERA JULIO
Published: January 2024

The purpose of this paper is to reflect on the education-technology duality with an addition: in crisis. When we talk about education, we refer to the formal and superior. The reflection points out and focuses its analysis, on the one hand, on the marked reflection of institutionalized rules (myths) contained in the environments of educational organizations in which technology is considered the appropriate means to achieve educational purposes and ends, because " regardless of their possible efficiency, they make the organization look adequate, rational and modern” (Meyer and Rowan, 1999, p.83). And, on the other, it reflects on technology from conceptions of order, resorting to the concept of ambiguity understanding it as "a lack of clarity in reality, causality and intentionality" (March 1994). It is recognized that today the world is characterized by uncertainty in the sense that there are no certainties in any field and crises such as the health emergency that impacted education. As a product of this theoretical work, we have educational organizations legitimized before society as modern, flexible, and harmonious organizations, but with an ambiguous, imprecise technology and with little clarity to achieve educational purposes.
A Transaction Cost Approach to the Role of Cooperatives in Energy Transition
Authors:   IAGBT, f f
Published: January 2024

Purpose - This paper investigates how community-based approaches to renewable energy help in to substitute renewables for fossil fuels in Europe in the context of transaction costs.
Design/Methodology/Approach - This paper uses qualitative research methods, which feature online interviews focusing on 14 REScoop.eu member cooperatives and organizations, four non-REScoop.eu organizations, and a complementary online survey of 32 respondent REScoop.eu member cooperatives.
Findings - The paper finds that (a) cooperative legal form is not seen to generate the perceived advantages to cooperatives in renewable energy proliferation, or (b) in addressing associated land use issues; further (c), there a perception that renewable energy cooperatives directly help in renewable energy proliferation by localizing energy production and stimulating the local economy (d) by making renewables more acceptable at the local level, and (e) by building trust-based relationships within these communities. It is also perceived that (f) such cooperatives are hampered by the general lack of corresponding professional and technical expertise, volunteer work, and the democratic decision-making process.
Research Implications - The major implication is that localization is key for renewable energy cooperatives to be significant drivers of renewable energy in Europe. The paper contributes insights on cooperative organization form itself, and by addressing how transaction costs help in renewable energy proliferation.
Mixture of Large and Small Firms in General Equilibrium
Authors:   IAGBT, f f
Published: January 2024

Purpose - This paper develops a tractable model of general equilibrium featuring a (1) mixture of large and small firms in a sector, (2) managerial activities of large firms, and (3) leadership of large firms over small firms in product and labor markets. This paper aims to incorporate strategic firm behavior into a general equilibrium.
Design/Methodology/Approach - This paper launches a game-theoretic approach for a mixture of large and small firms within an industry. Within the framework, small firms form a coalition to stand against large firms. Thus, it models that large firms and the coalition of small firms interact strategically. Unlike small firms, large firms hire managers to supervise production workers and improve production efficiency.
Findings - With manager skills, the leadership of large firms is enhanced. That is, the market share of large firms expands, while that of small firms shrinks. With the shrinkage, firm selection occurs within the coalition of small firms. Thus, small firms of low-ability entrepreneurs exit the sector, and the resources are reallocated toward higher skills and higher-ability entrepreneurs. Large firms affect the pattern of labor demand by creating higher-paying jobs for skills.
Research Implications - As large firms have stronger market leadership, aggregate income increases and wage inequality widens. This paper can contribute to the literature of oligopolistic competition and general equilibrium.
O uso do Instagram como ferramenta de ensino e aprendizagem
Authors: Moreira Thais Caldas Paiva , Santos Renato Trevizano dos , Santos Djacinto Monteiro dos , Soeira Marcelo Rezende Calça , Vieira Jacques Felipe Iatchuk , Farias Cléver Ricardo Guareis de
Published: January 2024

Este trabalho teve como objetivo explorar a efetividade do uso de uma rede social como recurso de ensino-aprendizagem complementar ao ambiente virtual de aprendizagem (AVA) institucional, tradicionalmente empregado em cursos de diversos níveis na modalidade Ensino à Distância. Para isso, foi realizado um estudo de caso com duas disciplinas de graduação oferecidas pela Universidade ZZZZ: Cálculo I e Teoria da Literatura. O estudo de caso partiu da criação e gerenciamento de um perfil na rede social Instagram para cada uma dessas disciplinas durante todo o seu período de oferecimento no primeiro bimestre de 2021. Nesse período, foram coletados dados quantitativos e qualitativos a respeito do uso realizado pelos estudantes. Os resultados obtidos evidenciam aceitação e entusiasmo dos estudantes em relação à rede social como ferramenta de apoio complementar de baixa complexidade de utilização, bem como indicam similaridade nos níveis de engajamento dos alunos das duas disciplinas. Esses resultados permitem vislumbrar novas possibilidades de interação orgânica dos estudantes com os conteúdos formalmente expostos no ambiente virtual de aprendizagem.
Estágio supervisionado em ensino de Física
Authors: Leonel Andre Ary
Published: January 2024

Neste artigo, são apresentadas as atividades desenvolvidas no âmbito da disciplina de Estágio Supervisionado em Ensino de Física durante a pandemia de COVID-19. É evidenciado o caráter integrador da disciplina e o seu desenvolvimento como parte de um processo contínuo de reflexão em torno dos desafios enfrentados e da busca por uma formação que propicie a autoria e o uso crítico e criativo das Tecnologias Digitais da Informação e Comunicação (TDIC). A partir da descrição da arquitetura pedagógica da disciplina, são analisadas as percepções dos estagiários, futuros professores de Física, acerca das atividades desenvolvidas ao longo do estágio, com o objetivo de evidenciar as oportunidades e desafios para a formação docente neste tempo pandêmico. Tais percepções foram levantadas por meio de uma enquete de reação, elaborada com a atividade enquete da plataforma Moodle, e destacam como principais desafios: administrar o tempo e conciliar com outras atividades, sobrecarga de atividades, falta de contato com os estudantes do Ensino Médio, falta de diálogo com colegas da disciplina de estágio e saúde física e mental debilitada. Para os estagiários, o uso de diferentes TDIC para interação e construção do conhecimento, a gravação e disponibilidade das aulas síncronas e a disponibilidade do professor para sanar as dúvidas entre uma atividade e outra foram indispensáveis para o enfrentamento dos desafios elencados.
"Currículo básico" uma contribuição para a escola pública brasileira” (1988)
Authors: Tonidandel Sandra , Orso Paulino José
Published: January 2024

O objetivo deste artigo é difundir à comunidade científica vinculada à História e à Historiografia da Educação, o Currículo Básico: uma contribuição para a escola pública brasileira (1988), elaborado em Curitiba, no Paraná. Esse documento marca a primeira proposta de institucionalização da Pedagogia Histórico-Crítica no país, ocorrida apenas quatro anos após figurar na história da educação brasileira com esta nomenclatura. O método interpretativo empregado na apresentação desta fonte foi o materialista histórico, de abordagem dialética, cuja metodologia empreendida, a partir das categorias classes, lutas de classes, contradição, mediação e totalidade resultou em uma descrição contextual analítica deste vestígio documental. Em largas linhas, estabelecemos as principais conexões que animaram o Movimento dos Educadores de Curitiba na construção desta proposta curricular durante os anos 1980 e, na sequência, apresentamos os pressupostos teóricos que balizaram o documento. Por um lado, a análise revela a importância da preservação das fontes históricas para a História e a Historiografia da Educação, e, por outro, a contribuição considerável na direção de se construir uma proposta pedagógica consonante com os interesses da classe trabalhadora.
Explorando a geodiversidade do Baixo Rio Doce
Authors: Capaz Thiago de Alcântara , Neves Bianca Pereira das , Campos Carlos Roberto Pires
Published: January 2024

Introdução. O trabalho explora temas geocientíficos em espaços não formais do Baixo Rio Doce, em território Capixaba. Objetivo. A pesquisa buscou identificar as potencialidades dos espaços educativos do Baixo Rio Doce e como estes podem ser utilizados como referência para aulas de campo em geociências a partir da implementação de práticas de intervenção pedagógica na Educação Básica, sob a ótica interdisciplinar. Metodologia. A pesquisa é de natureza qualitativa, do tipo estudo de caso. A estratégia adotada para coleta de dados foi a observação participante, realizada durante as aulas de campo no Baixo Rio Doce, pelas disciplinas optativas do Programa de Pós-Graduação em Educação em Ciências e Matemática (Educimat) do Instituto Federal do Espírito Santo (IFES). Resultados. Observou-se o reconhecimento dos processos geológicos e geomorfológicos do Rio Doce e, em paralelo, foram aperfeiçoados os instrumentos de intervenção durante as atividades de campo, confirmando o apontamento das potencialidades educativas dos espaços não formais. Conclusão. Com vistas à divulgação científica, reconhecemos que tais práticas podem ser replicadas e adaptadas a todos os níveis da Educação Básica.
A gincana geológica como recurso didático para ensino das Geociências em escolas técnicas
Authors: Dias Marília Cristina Santos Souza , Costa Silas Samuel dos Santos , Canova Rodrigo Libório Ferreira , Andrade Jhordan Nascimento Dias , Fernandes Dara Luany Alves , Aguiar Adriano Henrique Andrade de
Published: January 2024

Introdução. As Geociências fazem parte da área de Ciências da Natureza na BNCC e são geralmente ensinadas em disciplinas como Ciências, Geografia e Ciências da Natureza e suas Tecnologias. Porém, as aulas costumam ser expositivas, o que limita o envolvimento dos alunos. Objetivo. A gincana surge como alternativa pedagógica para tornar o ensino de Geociências mais atraente e eficaz, permitindo que os alunos explorem conceitos geológicos de forma interativa, estimulando sua curiosidade e sua motivação para aprender. Metodologia. No caso do Seridó Geoparque Mundial da UNESCO (SGMU), a gincana geológica homenageou o Dia do Geólogo e promoveu o conhecimento sobre o geopatrimônio local. Resultados. Participaram 115 alunos do ensino médio dos cursos técnicos de Mineração da Escola Estadual Manoel Salustino e do Instituto Federal do Rio Grande do Norte, Campus Parelhas. Conclusão. Com a temática "Geologia do Cotidiano", o evento interpretou o geopatrimônio do Geoparque sob a ótica das Geociências, gerando diversos resultados elaborados pelos estudantes.
Modelo geológico 3D da bacia de Taubaté e aplicação na pesquisa educacional em geociências
Authors: Carneiro Celso Dal Ré , Carvalho Reynaldo Souza de , Padovani Stefani Geanine , Ferreira Ricardo , Pinto Antonio Vitor Francisco , Vieira Larissa Cardoso
Published: January 2024

Introdução e Objetivo. Este artigo sintetiza os resultados de projeto de pesquisa que objetivou produzir modelos tridimensionais da Bacia Sedimentar de Taubaté. O projeto integra um corpo maior de pesquisa que produz representações e modelos tridimensionais de bacias sedimentares e feições de relevo do Brasil, com finalidade didática. Metodologia. O método de investigação envolveu revisão bibliográfica, estudo sistemático de artigos e modelagem computacional 3D para geração de maquetes físicas. Os trabalhos envolveram processamento de dados de sensores remotos espectrais e dados de perfurações profundas executadas na bacia. Resultados. Cada maquete gerada deverá compor um acervo de materiais didáticos de Geociências para a escola básica e o ambiente universitário. Os kits e materiais deverão ser distribuídos a professores de ensino básico e superior, por meio de workshops e tutoriais sobre uso didático dos recursos. O modelo tridimensional da Bacia de Taubaté contribuirá para melhor entendimento da morfologia, estrutura e história geológica dessa importante região do Estado de São Paulo. Conclusão. Pretende-se elaborar guias didáticos que auxiliem professores de educação básica a utilizarass maquetes em suas atividades didáticas.
Comparison of mortality between open and closed pelvic bone fractures in Korea using 1:2 propensity score matching: a single-center retrospective study
Authors: Yoo Jaeri , Choi Donghwan , Kang Byung Hee
Published: January 2024

Purpose: Open pelvic bone fractures are relatively rare and are considered more severe than closed fractures. This study aimed to compare the clinical outcomes of open and closed severe pelvic bone fractures.Methods: Patients with severe pelvic bone fractures (pelvic Abbreviated Injury Scale score, ≥4) admitted at a single level I trauma center between 2016 and 2020 were retrospectively analyzed. Patients aged <16 years and those with incomplete medical records were excluded from the study. The patients were divided into open and closed fracture groups, and their demographics, treatment, and clinical outcomes were compared before and after 1:2 propensity score matching. Results: Of the 321 patients, 24 were in the open fracture group and 297 were in the closed fracture group. The open fracture group had more infections (37.5% vs. 5.7%, P<0.001) and longer stays in the intensive care unit (median 11 days, interquartile range [IQR] 6–30 days vs. median 5 days, IQR 2–13 days; P=0.005), but mortality did not show a statistically significant difference (20.8% vs. 15.5%, P=0.559) before matching. After 1:2 propensity score matching, the infection rate was significantly higher in the open fracture group (37.5% vs. 6.3%, P=0.002), whereas the length of intensive care unit stay (median 11 days, IQR 6–30 days vs. median 8 days, IQR 4–19 days; P=0.312) and mortality (20.8% vs. 27.1%, P=0.564) were not significantly different. Conclusions: The open pelvic fracture group had more infections than the closed pelvic fracture group, but mortality was not significantly different. Aggressive treatment of pelvic bone fractures is important regardless of the fracture type, and efforts to reduce infection are important in open pelvic bone fractures.
Una respuesta colectiva a nuestros desafíos globales: un enfoque de bien común y de “configuración del mercado”
Authors: Mazzucato Mariana
Published: January 2024

Para abordar de manera efectiva los grandes desafíos de nuestro tiempo, no podemos simplemente hacer pequeños ajustes y arreglar las fallas del mercado. Tenemos que formar activamente los mercados para cumplir el objetivo de generar un crecimiento más sostenible e inclusivo. Este artículo sostiene que una economía orientada a objetivos requiere un enfoque de configuración del mercado; uno que acompañe el concepto de bien público con el enfoque de bien común necesario para diseñar la interfaz para esta colaboración. Se trata de estructurar las condiciones y los mecanismos de gobernanza que den forma a las capacidades, herramientas, instituciones y asociaciones necesarias para tomar medidas concretas. Desarrollar inteligencia colectiva en estas dimensiones ex ante es esencial para maximizar el valor público para todos los actores involucrados. Este artículo expone cómo se puede conceptualizar y combinar un marco de configuración de mercado y de bien común. Es importante destacar que las misiones pueden utilizarse para orientar y coordinar políticas, instituciones, innovación e inversiones en torno a objetivos claros, ambiciosos y mensurables. Además, este documento aborda las implicaciones para los desafíos globales clave, desde el cambio climático hasta las pandemias.
Constructing three-dimensional architectures to design advanced anodes materials for sodium-ion batteries: from nanoscale to microscale
Authors: Sun Yu-Feng , Li Yu , Gong Yu-Teng , Qiu Zhi-Xu , Qian Ji , Bai Ying , Wang Zi-Lu , Zhang Ri-Peng , Wu Chuan
Published: January 2024

Sodium-ion batteries (SIBs) are emerging as a possible substitute for lithium-ion batteries (LIBs) in low-cost and large-scale electrochemical energy storage systems owing to the lack of lithium resources. The properties of SIBs are correlated to the electrode materials, while the performance of electrode materials is significantly affected by the morphologies. In recent years, several kinds of anode materials involving carbon-based anodes, titanium-based anodes, conversion anodes, alloy-based anodes, and organic anodes have been systematically researched to develop high-performance SIBs. Nanostructures have huge specific surface areas and short ion diffusion pathways. However, the excessive solid electrolyte interface film and worse thermodynamic stability hinder the application of nanomaterials in SIBs. Thus, the strategies for constructing three-dimensional (3D) architectures have been developed to compensate for the flaws of nanomaterials. This review summarizes recent achievements in 3D architectures, including hollow structures, core-shell structures, yolk-shell structures, porous structures, and self-assembled nano/micro-structures, and discusses the relationship between the 3D architectures and sodium storage properties. Notably, the intention of constructing 3D architectures is to improve materials performance by integrating the benefits of various structures and components. The development of 3D architecture construction strategies will be essential to future SIB applications.
AgeTech, Ethics and Equity: Towards a Cultural Shift in AgeTech Ethical Responsibility
Authors:   University of Dundee, Fang Mei Lan , Sixsmith Judith ,   University of Dundee, Morris Jacqui ,   University of Dundee, Lim Chris ,   University of Dundee, Altman Morris ,   University of Dundee, Loret Hannah ,   University of Dundee, Rogowsky Rayna ,   University of Dundee, Sixsmith Andrew ,   Simon Fraser University, White Rebecca ,   Simon Fraser University, Marquine Raymundo Taiuani ,   Universidade Federal do Parana
Published: January 2024

Population ageing is a global phenomenon which presents major challenges for the provision of care at home and in the community (ONS, 2018). Challenges include the human and economic costs associated with increasing numbers of older people with poor physical and mental health, loneliness, and isolation challenges (Mihalopoulos et al., 2020). The global ageing population has led to a growth in the development of technology designed to improve the health, well-being, independence, and quality of life of older people across various settings (Fang, 2022). This emerging field, known as “AgeTech,” refers to “the use of advanced technologies such as information and communications technologies (ICT’s), technologies related to e-health, robotics, mobile technologies, artificial intelligence (AI), ambient systems, and pervasive computing to drive technology-based innovation to benefit older adults” (Sixsmith, et al., 2020 p1; see also Pruchno, 2019; Sixsmith, Sixsmith, Fang, and Horst, 2020). AgeTech has the potential to contribute in positive ways to the everyday life and care of older people by improving access to services and social supports, increasing safety and community inclusion; increasing independence and health, as well as reducing the impact of disability and cognitive decline for older people (Sixsmith et al, 2020). At a societal level, AgeTech can provide opportunities for entrepreneurs and businesses (where funding and appropriate models exist) (Akpan, Udoh and Adebisi, 2022), reduce the human and financial cost of care (Mihalopoulos et al., 2020), and support ageing well in the right place (Golant, 2015).
Solid Lubricants Used at Extreme Conditions Experienced in Machining: A Comprehensive Review of Recent Developments and Applications
Authors: Hedayati Hiva , Mofidi Asadollah , Al-Fadhli Abdullah , Aramesh Maryam
Published: January 2024

Contacting bodies in extreme environments are prone to severe wear and failure due to friction and seizure, which are associated with significant thermal and mechanical loads. This phenomenon greatly impacts the economy since most essential components encounter these challenges during machining, an unavoidable step in most manufacturing processes. In machining, stress can reach 4 GPa, and temperatures can exceed 1000 °C at the cutting zone. Severe seizure and friction are the primary causes of tool and workpiece failures. Liquid lubricants are popular in machining for combatting heat and friction; however, concerns about their environmental impact are growing, as two-thirds of the 40 million tons used annually are discarded and they produce other environmental and safety issues. Despite their overall efficacy, these lubricants also have limitations, including ineffectiveness in reducing seizure at the tool/chip interface and susceptibility to degradation at high temperatures. There is therefore a push towards solid lubricants, which promise a reduced environmental footprint, better friction management, and improved machining outcomes but also face challenges under extreme machining conditions. This research aims to provide a thorough insight into solid lubricant use in machining, discussing their mechanisms, effectiveness, constraints, and potential to boost productivity and environmental sustainability.
Quality of Life and Treatment Modalities in Patients with Interstitial Cystitis: A Patients Perspective
Authors: Ginkel Charlotte van , Martens Frank , Scholtes Mathilde , Heesakkers John , Janssen Dick AW
Published: January 2024

Background: Quality of life (QoL) in IC/BPS patients is an evidence gap in guidelines, because studies are limited and outdated. Therefore, guidelines might not reflect the current situation accurately, and no possible improvements in QoL of these patients. Secondly, guidelines suggest multimodal approach in therapy, however unknown is how the efficacy of these therapies are perceived by the patient themselves. The aim of this study is to investigate the perception of IC/BPS patients on their QoL and to determine which treatments they received and how they evaluate the efficacy of these various (alternative) therapies.Methods: Quantitative retrospective database study in IC/BPS patients, compiled of existing patient survey data (n=217) from July 2021. Results: The QoL of patients is affected significantly by IC/BPS. This is evident from the substantial self-reported impact by patients, the various affected domains on EQ-5D 5L. The QoL was not negatively affected by delayed diagnosis, but there were differences between female and males. Secondly, there was the wide array of (alternative) treatments utilized, although some have doubtful results and high dropout rates. Conclusion: QoL is considerably impaired in IC/BPS patients. Coagulation therapy and intravesical GAG therapy were most appreciated treatments. The diverse responses and adherence to various treatments warrant a personalized approach (phenotype-oriented therapy). To achieve improvement in the QoL, it is important to incorporate the patient’s perspective in treatment guidelines.
Strategic Mastery: Uncleashing the Power of LNG Program Development through Advanced Techniques
Authors: JOHNSON NNADIKWE
Published: January 2024

With the global supply of LNG experiencing unprecedented growth, the industry is on the brink of a programmed glut, further exacerbated by the challenges posed by weaker energy pricing. In light of this, it is expected that marginal programs will be deferred temporarily, yet continuously assessed to enhance their economic potential in the future. Moreover, recent setbacks in LNG programs, such as cost overruns and delays, highlight the critical need for a unique conceptual design master plan. This plan will serve as a powerful tool to evaluate and optimize new programs, ensuring improved economic viability and boosting rates of return. By leveraging advanced analytical frameworks, innovative technologies, and comprehensive risk assessments, this study aims to develop a transformative approach that drives sustainable growth and profitability in the dynamic landscape of LNG program development." "This paper centers around the development of a comprehensive conceptual design master plan aimed at optimizing the total program economics across various areas, including sub-sea, offshore, and onshore advancements. The master plan serves as a crucial framework for identifying opportunities to reduce costs and enhance program definition, drawing insights from selective benchmarks derived from recent successful LNG programs. The ultimate objective is to boost the program rate of return while improving overall program definition, thereby mitigating the risks of cost overruns and schedule delays that have plagued the industry. By implementing this master plan, marginal programs stand a greater chance of becoming economically viable, fostering sustainable growth and enabling stakeholders to make informed decisions in the highly dynamic LNG landscape.
GC-MS analysis, Elemental and Nutritional Composition and Biological Investigation of Medicinally Valued Fingerhuthia africana Lehm.
Authors: Ullah Hamid , Adil Muhammad , Filimban Faten Zubair
Published: January 2024

Fingerhuthia africana Lehm belongs to family Poaceae, is an erect perennial grass used traditionally to cure different diseases. The current study was carried out to find the bioactive compounds by GC-MS, elemental analysis through atomic absorption spectrophotometry, proximate analysis by AOAC, genotoxic activity through comet assay, antioxidant activity through DPPH and antidiarrheal activity through castor oil induce diarrhea followed by charcoal meal on mice model. GC-MS chromatogram represents different compounds detected in the crude extract. Major pharmacological bioactive compounds are 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl-; 4-Methyl itaconate; .alpha.-Terpineol; 1,2,3-Propanetriol, 1-acetate; Benzofuran, 2,3-dihydro-; Caryophyllene oxide; Hinesol; n-Hexadecanoic acid; 9,12-Octadecadienoic acid (Z,Z)-, methyl ester; Hexadecanoic acid and methyl ester. Elemental analysis of stem, leaves and roots of the plant show the presence of (macro and micro) nutrients such as Ca, Mg, K, Na, Cu, Pb, Zn, Mn, Fe, Cd and Co were absent in all parts. Proximate analysis of different parts revealed the presence of moisture contents (8.57%), ash (9.77%), fats contents (5.96%), fibers contents (45.03%), protein (3.62%), carbohydrates (39.71%) and Gross energy (Kcal/100g) (220.10). The ethanolic extract show dose-dependent genoprotective potential (127.38 ± 1.16), (83.28 ± 0.65), and (44.08 ± 1.40) at 50, 75, and 100 mg/100 ml, respectively, as compared to the methanolic extract which show genotoxic activity (85.13 ± 1.23) at high dose. After 90 minutes at a concentration of 300 (g/ml), methanolic extract demonstrated the greatest antioxidant potential (79.5%), followed by aqueous extract (76.5%). The methanolic extract of F. africana demonstrated antidiarrheal efficacy, with the maximum inhibition of charcoal movement (83.78%) occurring at a dosage of 300 mg/kg, followed by doses of 200 and 100 mg/kg, 73.26% and 59.56%, respectively. The current research highlights that the plant contains a substantial quantity of micro and macro nutrients, possesses high nutritional value, and exhibits pharmacological activities. These properties render the plant suitable for developing remedies to treat various therapeutic diseases.
A Review of the Application of Ganoderma lucidum (Curtis) P. Karst. In Nanotechnology for the Treatment of Cancer
Authors: Eira Ana Alexandra Batista da , Fongang Fotsing Yannick Stéphane , Domingues Cátia , Jarak Ivana , Mascarenhas-Melo Filipa , Figueiras Ana
Published: January 2024

Ganoderma lucidum, commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits, and medicinal properties in traditional Chinese medicine. In recent years, the emerging field of nanotechnology has opened up new possibilities in order to use the remarkable properties of G. Lucidum at the nanoscale. The unique combination of bioactive compounds present in G. Lucidum, such as triterpenoids, polysaccharides, and peptides, has inspired interest in leveraging their therapeutic potential through nanotechnological approaches. Various nanomaterials, including nanoparticles, nanofibers, and nanocomposites, have been employed to encapsulate and deliver these bioactive components to target cells or tissues, enhancing stability, controlled release, and consequently their bioavailability. Nanotechnology-based strategies have been investigated for the efficient extraction and purification of bioactive compounds from G. Lucidum. The use of nanoscale materials has facilitated the extraction process, enhancing the yield and purity of the active components. Additionally, nanocarriers and nanoformulations have been developed to protect these sensitive bioactive compounds from degradation, ensuring their stability during storage and transportation. The use of G. Lucidum-based nanomaterials has shown promising results in several biomedical applications. Nanoparticles loaded with bioactive compounds derived from G. Lucidum have exhibited potent anticancer activity by targeting cancer cells, inducing apoptosis, and inhibiting tumor growth. Additionally, nanotechnology-based formulations have demonstrated immunomodulatory effects, promoting the activation of immune cells and enhancing the body's defense mechanisms. GL, combined with the potential of nanotechnology, presents an exciting frontier in the development of novel therapeutic and biomedical applications. The utilization of nanomaterials for extraction, delivery, and integration of bioactive compounds from G. Lucidum has shown immense potential for improving drug delivery, tissue engineering, and disease treatment. Further research and development in this interdisciplinary field are warranted to fully exploit the synergistic benefits offered by G. Lucidum, and nanotechnology, ultimately leading to innovative solutions for human health and well-being.
Examining the Role of Social Determinants of Health and Healthcare System Measures on COVID-19 Outcomes in 28 African Countries
Authors: Moise Imelda K , Ortiz-Whittingham Lola R , Owolabi Kazeem , Halwindi Hikabasa , Miti Benard A
Published: January 2024

Background
Although COVID-19 outcomes vary between and within countries, there is little published data on how aspects of social determinants of health (SDoH) affect COVID-19 outcomes in the African context.

Objective
The current study set to examine COVID-19 case and death rates and their correlates among African countries using data from different sources.

Methods
An ecological cross-sectional study comprising 28 African countries with a recent Demographic and Health Survey, DHS (2010-2018). Response variables were COVID-19 case and death rates (as of August 15, 2020). Covariates comprised three healthcare systems measures; rates of hospital beds (2005-2017), ventilators (2020) and doctors (2010-2018) per 10,000 population, and 9 broad topics common to multiple SDoH frameworks aggregated to the country level; geography (urban residence), wealth index, education, employment, crowding, and access to information. Rates per 10,000 population were calculated for healthcare measures and mapped for visualization. A Negative Binomial regression was used to assess whether aspects of SDoH are correlated with COVID-19.

Results
Our analysis indicated that 1 in 4 (25.1%) households in study countries are without clean water and handwashing access. Country-level health system capacity (hospital beds, ventilators, and medical doctors) varied considerably between the countries. Negative Binomial regression showed that the odds of COVID-19 morbidity and death was higher in countries with a high proportion of households without access to quality water and doctors per 10,000 people. Having a high proportional of educated women (1.003: 95% CI, 1.001 – 1.005), hospital beds per population and less people per room (0.959: 95% CI, 0.920 – 1.000) was negatively correlated with COVID-19 deaths while being insured and owning a mobile phone was correlated with illness.

Conclusion
Both aspects of SDoH and healthcare system contribute either negatively or positively to COVID-19 outcomes. Addressing healthcare system capacity and economic and environmental SDoH will be critical for mitigating the spread of COVID-19 and re-emerging diseases on the African continent.
New Technological Approach for Improving the Thermionic Energy Conversion Efficiency for Space-Power Applications and Deep Space Exploration
Authors: Lukin Alexander
Published: January 2024

Power sources that can consistently deliver high levels of energy over extended periods are crucial for various space applications. Among the many methods of energy generation, direct heat-to-electricity conversion without intermediate steps or moving components shows particular promise but also presents significant challenges. The aim of this research is to address these challenges by enhancing the energy efficiency of thermionic conversion, which transforms thermal energy into electrical energy, through the development and utilization of a novel class of emission nanomaterials known as multilayer carbyne-enriched 3D-shaped nano-interfaces. By manipulating the topological, physicochemical, and functional characteristics of these interfaces, we seek to optimize their thermionic conversion capabilities. Building on the recent discovery of collective atomic vibrations called phonon waves within transition domains of multilayer nanostructures, we have devised a new approach to enhance the efficiency of thermionic energy converters. This involves unlocking the predictive functionality of 2D-ordered linear-chain carbon-based multilayer emitters through the excitation and fine-tuning of collective atomic vibrations and nanoarchitecture. To achieve this, we propose employing a combination of techniques that leverage interface effects, enable phonon wave propagation, facilitate energy exchange, and capitalize on synergistic effects offered by the multilayer nano-enhanced interfaces. The resulting devices for thermionic energy conversion have the potential to significantly surpass the efficiency of existing plasma thermionic converters by several orders of magnitude. Moreover, these electricity-generating sources based on thermionic conversion represent fundamental options for the advancement of Lunar and Martian research missions, opening up possibilities for sustainable energy production in extraterrestrial environments.
Peptide-Based Biomaterials for Osteochondral Tissue Regeneration
Authors: Kapat Kausik , Kumbhakarn Sakshi , Sable Rahul , Gondane Prashil , Takle Shruti , Maity Pritiprasanna
Published: January 2024

The healing of osteochondral defects (OCD) resulting from injury, osteochondritis, or osteoarthritis in middle- and old-age individuals, bearing lesions in the cartilage and bone, pain, and loss of joint function, presents challenges to the clinical practitioners because of non-regenerative cartilage and the limitations of current therapies. Bioactive peptide-based osteochondral (OC) tissue regeneration is becoming more popular because it does not have the immunogenicity, misfolding, or denaturation problems associated with original proteins. Periodically, reviews are published on the regeneration of bone and cartilage; however, none of them address the simultaneous healing of these tissues in the complicated heterogeneous environment of the OC interface. As regulators of cell adhesion, proliferation, differentiation, angiogenesis, immunomodulation, and antibacterial activity, potential therapeutic strategies for OC defects utilizing bone and cartilage-specific peptides should be examined and investigated. Therefore, the main goal of this review is to study how they contribute to the healing of OC defects, either alone or in conjunction with other peptides and biomaterials.
Ethylene Action-Inhibition Improves Adventitious Root Induction in Adult Chestnut Tissues
Authors: Castro-Camba Ricardo , Neves Mariana , Correia Sandra , Canhoto Jorge , Vielba Jesús , Sánchez Conchi
Published: January 2024

Phase change refers to the process of maturation and transition from the juvenile to the adult stage. In response to this shift, certain species like chestnut lose the ability to form adventitious roots, thereby hindering the successful micropropagation of adult plants. While auxin is the main hormone involved in adventitious root formation, other hormones, such as ethylene, are also thought to play a role in its induction and development. In this study, experiments were carried out to determine the effects of ethylene on the induction and growth of adventitious roots. The analysis was performed in two types of chestnut microshoots derived from the same tree, a juvenile-like line with high rooting ability derived from basal shoots (P2BS) and a line derived from crown branches (P2CR) with low rooting responses. By means of the application of compounds to modify ethylene content or inhibit its signalling, the potential involvement of this hormone in the in-duction of adventitious roots was analyzed. Our results show that ethylene can modify the rooting competence of mature shoots, while the response in juvenile material was barely affected. To further characterize the molecular reasons underlying this maturation-derived shift in behaviour, specific gene expression analyses were developed. Findings suggest that several mechanisms, including ethylene signalling, auxin transport and epigenetic modifications, relate to the modu-lation of the rooting ability of mature chestnut microshoots and their recalcitrant behaviour.
Planning Regulations in BIM
Authors: Koutamanis Alexander
Published: January 2024

Planning regulations determine a substantial part of buildings but their constraints are usually not included in the setup of a BIM model or used explicitly for design guidance. This is symptomatic of wider tendencies and ingrained biases that emphasize tacit knowledge and assume that information in a project starts from scratch – an assumption that runs contrary to predesign information ordering practices, as well as to the findings of creativity studies. In terms of process control, it negates important possibilities for feedforward. The paper describes an exercise in which students collected planning regulations for a particular plot of land and modelled their constraints in BIM. The results suggest that converting such information into a foundation for design is constructive and feasible, even for novices, and produce a bandwidth view of project information that acknowledges pre-existing information and includes it in the BIM workflow. They also verify that, for a large part of Dutch housing, this foundation amounts to a considerable and binding part of the design that guides subsequent decisions.
Superconductors Exhibiting Enhanced or Diminished Resonance Characteristics within the Framework of the Bardeen-Cooper-Schrieffer Model
Authors: Koo Je Huan
Published: January 2024

The elevated or depressed transition temperatures observed in cuprate and pnictide superconductors and other exotic superconductors pose a challenge in the context of explaining them through the traditional Bardeen-Cooper-Schrieffer (BCS) models of superconductivity. A significant obstacle in understanding this phenomenon can be addressed by considering an alternative electron distribution. Our investigation has identified an anyonic distribution, where the occupancy of a site created by removing a hole is filled by an electron. In heavy fermion superconductors (HFSs) block spins must be included in the distribution. The interplay, that is, resonance between superconducting electrons within the conventional BCS framework and independent charge density waves (CDWs) might contribute to driving the high-transition-temperature superconductors (HTSCs).
Spatial and Temporal Dynamics of the Vegetation Cover from the Bijagual Massif, Boyacá, Colombia, during the 1986–2021 Period
Authors: Gil-Leguizamón Pablo Andrés , Pereña-Ortiz Jaime Francisco , Sánchez-Mata Daniel , Salvo-Tierra Ángel Enrique , Mercado-Gómez Jorge David , Morales-Puentes And María Eugenia
Published: January 2024

Landscape changes based on spectral responses allow showing plant cover changes through diversity, composition, and ecological connectivity. The spatial and temporal vegetation dynamics of the Bijagual Massif from 1986 to 2021 were analyzed as a measure of ecological integrity, conservation, and territory. The covers identified were high open forest (Hof), dense grassland of non-wooded mainland (Dgnm), a mosaic of pastures and crops (Mpc), lagoons (Lag), and bare and degraded lands (Bdl). The Bijagual Massif has 8,574.1 ha. In 1986, Dgnm occupied 42.6% of the total area, followed by Mpc (32.8%) and Hof (24.5%); by 2000, Mpc and Hof increased (43.7 and 28.1%, respectively), while Dgnm decreased (28%); by 2021, Dgnm was restricted to the northeastern zone and continued to decrease (25.2%), Mpc occupied 52.9%, Hof 21.7% and Bdl 0.1%. Of the three fractions of the connectivity probability index, only dPCintra and dPCflux contribute to ecological connectivity. Hof and Dgnm show patches with biota habitat quality and availability. Between 1986 and 2021, Dgnm lost 1,489 ha (41%) and Hof 239.5 ha (11%). Mpc replaced various covers (1,722.2 ha; 38%) in 2021. Bijagual has a valuable biodiversity potential limited by Mpc. Territorial planning and sustainable agroecological and ecotourism proposals are required due to the context of the ecosystems.