bluuebunny/crossref_metadata_2025 huggingface dataset:
Dark Grand Unification in the axiverse: decaying axion dark matter and spontaneous baryogenesis
Authors: Foster Joshua W. , Kumar Soubhik , Safdi Benjamin R. , Soreq Yotam
Published: December 2022

Abstract

The quantum chromodynamics axion with a decay constant near the Grand Unification (GUT) scale has an ultralight mass near a neV. We show, however, that axion-like particles with masses near the keV–PeV range with GUT-scale decay constants are also well motivated in that they naturally arise from axiverse theories with dark c gauge groups. We demonstrate that the correct dark matter abundance may be achieved by the heavy axions in these models through the misalignment mechanism in combination with a period of early matter domination from the long-lived dark glueballs of the same gauge group. Heavy axion dark matter may decay to two photons, yielding mono-energetic electromagnetic signatures that may be detectable by current or next-generation space-based telescopes. We project the sensitivity of next-generation telescopes including Athena, AMEGO, and e-ASTROGAM to such decaying axion dark matter. If the dark sector contains multiple confining gauge groups, then the observed primordial baryon asymmetry may also be achieved in this scenario through spontaneous baryogenesis. We present explicit orbifold constructions where the dark gauge groups unify with the SM at the GUT scale and axions emerge as the fifth components of dark gauge fields with bulk Chern-Simons terms.
Analysis of Agglomerate Fog Meteorological Characteristics in Anhui Province Based on Traffic Accident Data
Authors: Gao Jingjing , Tian Hua , Li Aixun , Song Jianyang , Zhu Xiaoxiang
Published: December 2022

Using the data of five agglomerate-fog-related traffic accidents during 2014–2017 and fog-related expressway accidents during 2013–2018 assessed by the Anhui provincial traffic authorities and corresponding meteorological observation data, this article analyzes the spatio-temporal characteristics, geographical environment and weather background of agglomerate-fog-related accidents in detail and identifies the characteristics of changes in terms of visibility, humidity, temperature and wind when agglomerate fog occurs. Furthermore, an agglomerate fog forecast index has been established in Anhui Province to provide a reference basis for the agglomerate fog forecast, early warning and prevention.
Healthcare utilization and psychiatric morbidity in violent offenders: findings from a prospective cohort study
Authors: Tärnhäll André , Björk Jonas , Wallinius Märta , Gustafsson Peik , Billstedt Eva , Hofvander Björn
Published: December 2022

Purpose

Although persistent offenders with histories of imprisonment and violence have disproportionate high rates of psychiatric disorders, little is known of their psychiatric healthcare utilization (HCU) and HCU-associated factors. This study aimed to explore psychiatric HCU, psychiatric morbidity, and psychotropic prescription drugs in violent offenders with a history of incarceration.

Methods

Male offenders aged 18–25 (n = 266) imprisoned for violent and/or physical sexual offenses were clinically assessed in 2010–2012 and prospectively followed in Swedish national registries through 2017. Register-based information regarding HCU, psychiatric morbidity, and psychotropic drugs was tracked and compared with a general population group (n = 10,000) and across offending trajectory groups. Baseline risk factors were used to explain prospective psychiatric HCU in violent offenders.

Results

Violent offenders used less general healthcare and psychiatric outpatient care, but more psychiatric inpatient care and were more often given psychiatric diagnoses and psychotropic drugs than the general population. Participants previously assigned to persisting offending trajectory groups had higher rates of psychiatric HCU than those assigned to a desisting trajectory. In multivariable regression models, psychiatric HCU was associated with anxiety disorders, prior psychiatric contact, placement in a foster home, psychopathic traits, low intellectual functioning, and persistent offending.

Conclusions

Violent offenders are burdened by extensive and serious psychiatric morbidity and typically interact with psychiatric healthcare as inpatients rather than outpatients. Knowledge about their backgrounds, criminal behaviors, and psychiatric statuses can aid the planning of psychiatric services for this troublesome group.
An empirical noise model for the benefit of model-based hydrodynamic leveling
Authors: Afrasteh Y. , Slobbe D. C. , Verlaan M. , Klees R. , Guarneri H. , Keyzer L. , Pietrzak J. , Sacher M. , Snellen M. , Zijl F.
Published: December 2022

The main objective of this study is to develop and analyze an empirical noise model for model-derived coastal summer mean water levels (SMWLs) and use that to obtain a more realistic quality impact of combining hydrodynamic leveling and Unified European Leveling Network (UELN) data in realizing the European Vertical Reference System (EVRS). We considered three state-of-the-art hydrodynamic models for the Northeast Atlantic Ocean, including the North Sea and Wadden Sea; AMM7, DCSMv6-ZUNOv4, and 3D DCSM-FM. Moreover, we assess the spatiotemporal performance of these three models in representing coastal SMWLs. The empirical noise models are determined from the differences between observation- and model-derived SMWLs at coastal tide gauges. All three noise models show that the model noise is indeed correlated over sea distances up to hundreds of kilometers. At the same time, they all show a relatively large discontinuity at the origin (i.e., nugget effect); between 12.1 cm$$^2$$

2

(3D DCSM-FM) and 16.3 cm$$^2$$

2

(DCSMv6-ZUNOv4). The variance (i.e., covariance at zero sea distance) for these two models is 15.3 cm$$^2$$

2

and 21.7 cm$$^2$$

2

, respectively. Averaging the water levels over three summers, lowered the variance and nugget effect for 3D DCSM-FM to 12.7 cm$$^2$$

2

and 10.0 cm$$^2$$

2

, respectively. Our analysis also showed that between 30 and 50% of the variance has to be attributed to errors in the vertical referencing of the tide gauges. We lacked the information to assess what proportion of the observed noise covariances should be attributed to these errors. The performance assessments revealed significant variations over both space and time as well as among the three hydrodynamic models. The results suggest that there is still room for model improvement. In the final experiments, we used the noise model of the best overall performing model (i.e., 3D DCSM-FM) to reassess the quality impact of combining hydrodynamic leveling and UELN data in realizing the EVRS. The results suggest that not including the noise covariances leads to an overestimation of the total quality impact by $$7\%$$

7
%

and $$8\%$$

8
%

, when we average the water levels over one and three summer periods, respectively.
Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents
Authors: Reimann Hauke , Stopper Helga , Hintzsche Henning
Published: December 2022

Although micronuclei are well-known biomarkers of genotoxic damage, the biological consequences of micronucleus induction are only poorly understood. To further elucidate these consequences, HeLa cells stably expressing histone 2B coupled with green fluorescent protein were used for long-term live cell imaging to investigate the fate of micronuclei and micronucleated cells after treatment of cells with various genotoxic agents (doxorubicin (20, 30 and nM), tert-butyl hydroperoxide (tBHP, 50, 100 and 150 µM), radiation (0.5, 1 and 2 Gy), methyl methanesulfonate (MMS, 20, 25 and 30 µg/ml) and vinblastine (1, 2 and 3 nM)). Most micronuclei persist for multiple cell cycles or reincorporate while micronucleated cells were more prone to cell death, senescence and fatal mitotic errors compared to non-micronucleated cells, which is consistent with previous studies using etoposide. No clear substance-related effects on the fate of micronuclei and micronucleated cells were observed. To further investigate the fate of micronuclei, extrusion of micronuclei was studied with treatments reported as inducing the extrusion of micronuclei. Since extrusion was not observed in HeLa cells, the relevance of extrusion of micronuclei remains unclear. In addition, degradation of micronuclei was analysed via immunostaining of γH2AX, which demonstrated a high level of DNA damage in micronuclei compared to the main nuclei. Furthermore, transduction with two reporter genes (LC3B-dsRed and LaminB1-dsRed) was conducted followed by long-term live cell imaging. While autophagy marker LC3B was not associated with micronuclei, Lamin B1 was found in approximately 50% of all micronuclei. While degradation of micronuclei was not observed to be a frequent fate of micronuclei, the results show impaired stability of DNA and micronuclear envelope indicating rupture of micronuclei as a pre-step to chromothripsis.
Annihilating Entanglement Between Cones
Authors: Aubrun Guillaume , Müller-Hermes Alexander
Published: December 2022

Every multipartite entangled quantum state becomes fully separable after an entanglement breaking quantum channel acted locally on each of its subsystems. Whether there are other quantum channels with this property has been an open problem with important implications for entanglement theory (e.g., for the distillation problem and the PPT squared conjecture). We cast this problem in the general setting of proper convex cones in finite-dimensional vector spaces. The max-entanglement annihilating maps transform thek-fold maximal tensor product of a cone$${\textsf{C}}_1$$C1into thek-fold minimal tensor product of a cone$${\textsf{C}}_2$$C2, and the pair$$({\textsf{C}}_1,{\textsf{C}}_2)$$(C1,C2)is called resilient if all max-entanglement annihilating maps are entanglement breaking. Our main result is that$$({\textsf{C}}_1,{\textsf{C}}_2)$$(C1,C2)is resilient if either$${\textsf{C}}_1$$C1or$${\textsf{C}}_2$$C2is a Lorentz cone. Our proof exploits the symmetries of the Lorentz cones and applies two constructions resembling protocols for entanglement distillation: As a warm-up, we use the multiplication tensors of real composition algebras to construct a finite family of generalized distillation protocols for Lorentz cones, containing the distillation protocol for entangled qubit states by Bennett et al. (Phys Rev Lett 76(5):722, 1996) as a special case. Then, we construct an infinite family of protocols using solutions to the Hurwitz matrix equations. After proving these results, we focus on maps between cones of positive semidefinite matrices, where we derive necessary conditions for max-entanglement annihilation similar to the reduction criterion in entanglement distillation. Finally, we apply results from the theory of Banach space tensor norms to show that the Lorentz cones are the only cones with a symmetric base for which a certain stronger version of the resilience property is satisfied.
Assessing Clinical Acumen in Predicting Acute Appendicitis in Emergency Surgery: A Prospective Study
Authors: Lloyd Angus J. , Boland Michael R. , Cleere Eoin , Fallon Frances , Toale James , Hill Arnold D. K.
Published: December 2022

Background

Clinical acumen and experience are critical in the diagnosis of the commonest surgical emergency, acute appendicitis. However, there is an increasing focus on haematological and radiological parameters in reaching the diagnosis of appendicitis, which can negate the importance of clinical findings. The aim was to assess the accuracy of each grade of the surgical team in diagnosing acute appendicitis using clinical acuity alone and compare them to each other as well as validated predictive scores.

Methods

A prospective single‐centre study was performed over a six‐month period (Dec 2020–May 2021). All patients presenting to the emergency department with right iliac fossa pain were included.

Results

A total of 180 patients were included of whom 35% were male. Mean age was 36.2 years (range 16–91). 51.1% had a final diagnosis of appendicitis, of which 91.3% were managed surgically and 8.7% were treated conservatively with antibiotics. Consultants were correct in their prediction of appendicitis in 84.6% of cases (females—83.4%, males—86.6%). Registrars accurately predicted appendicitis in 82.2% of patients (females—80.3%, males—85.7%), whilst house officers (SHOs) and interns were right in 73.8% (females—69.2%, males—82.5%) and 72.7% (females—66.6%, males—83.9%) of cases, respectively. In patients with a histological or radiological diagnosis of appendicitis, the mean Acute Inflammatory Response Score and Acute Appendicitis Score were 7.0 (high risk ≥ 9) and 12.5 (high risk ≥ 16), respectively. Clinicians had superior diagnostic accuracy when compared with both the clinical scores used.

Conclusion

Seniority was associated with improved diagnostic accuracy in clinically predicting acute appendicitis. This study showed that the clinical judgement of experienced surgeons is more reliable than clinical scores in the diagnosis of appendicitis.
The sky compass network in the brain of the desert locust
Authors: Homberg Uwe , Hensgen Ronja , Jahn Stefanie , Pegel Uta , Takahashi Naomi , Zittrell Frederick , Pfeiffer Keram
Published: December 2022

Many arthropods and vertebrates use celestial signals such as the position of the sun during the day or stars at night as compass cues for spatial orientation. The neural network underlying sky compass coding in the brain has been studied in great detail in the desert locust Schistocerca gregaria. These insects perform long-range migrations in Northern Africa and the Middle East following seasonal changes in rainfall. Highly specialized photoreceptors in a dorsal rim area of their compound eyes are sensitive to the polarization of the sky, generated by scattered sunlight. These signals are combined with direct information on the sun position in the optic lobe and anterior optic tubercle and converge from both eyes in a midline crossing brain structure, the central complex. Here, head direction coding is achieved by a compass-like arrangement of columns signaling solar azimuth through a 360° range of space by combining direct brightness cues from the sun with polarization cues matching the polarization pattern of the sky. Other directional cues derived from wind direction and internal self-rotation input are likely integrated. Signals are transmitted as coherent steering commands to descending neurons for directional control of locomotion and flight.
Accumulation and distribution of heavy metals in surface sediments from the continental shelf adjacent to Abu Qir Bay, Egypt, as a function of grain size
Authors: Abdallah Maha Ahmed Mohamed
Published: December 2022

Estuarine-deposited sediment is an essential environmental medium that is widely used for characterizing anthropogenic contaminant levels in urban systems. It has significant implications for human health, and can directly impact aquatic biota. Assessment of Cr, Fe, and Cd contamination and their distribution in different grain size fractions of the surface sediments of Abu Qir Bay, one of the Mediterranean coastal bays, as an industrial development area has been investigated. Since the metals pose serious health risks, this research concentrated on investigating the concentrations and spatial distribution of Cr, Fe, and Cd in Abu Qir Bay sediments. Surface sediment samples were sieved, and six grain size fractions (1.0, 0.5, 0.25, 0.125, 0.063, and <0.063 mm) from each sample were selected for the analysis of studied metals. The data indicates a considerable contamination in all samples by Cr, Fe, and Cd. The finest sediment fractions (0.063 and <0.063 mm) contained the highest concentrations of Cr and Fe. The concentration of these metals was four times greater than in coarse-grained fractions. Silt plus clay (<0.063 mm) was the most critical mass component consisting of more than 40% of the total sediment stored in this fraction. Otherwise, the distribution of Cd in the sediment samples reveals high concentrations associated with the large fractions (1.0 and 0.5 mm) at all sediment samples.

Graphical Abstract
Adipokines in multiple sclerosis patients are related to clinical and radiological measures
Authors: Loonstra Floor C. , Falize Kim F. , de Ruiter Lodewijk R. J. , Schoonheim Menno M. , Strijbis Eva M. M. , Killestein Joep , de Vries Helga E. , Uitdehaag Bernard M. J. , Rijnsburger Merel
Published: December 2022

Background

An imbalance of adipokines, hormones secreted by white adipose tissue, is suggested to play a role in the immunopathology of multiple sclerosis (MS). In people with MS (PwMS) of the same age, we aimed to determine whether the adipokines adiponectin, leptin, and resistin are associated with MS disease severity. Furthermore, we aimed to investigate whether these adipokines mediate the association between body mass index (BMI) and MS disease severity.

Methods

Adiponectin, resistin, and leptin were determined in serum using ELISA. 288 PwMS and 125 healthy controls (HC) were included from the Project Y cohort, a population-based cross-sectional study of people with MS born in the Netherlands in 1966, and age and sex-matched HC. Adipokine levels and BMI were related to demographic, clinical and disability measures, and MRI-based brain volumes.

Results

Adiponectin levels were 1.2 fold higher in PwMS vs. HC, especially in secondary progressive MS. Furthermore, we found a sex-specific increase in adiponectin levels in primary progressive (PP) male patients compared to male controls. Leptin and resistin levels did not differ between PwMS and HC, however, leptin levels were associated with higher disability (EDSS) and resistin strongly related to brain volumes in progressive patients, especially in several grey matter regions in PPMS. Importantly, correction for BMI did not significantly change the results.

Conclusion

In PwMS of the same age, we found associations between adipokines (adiponectin, leptin, and resistin) and a range of clinical and radiological metrics. These associations were independent of BMI, indicating distinct mechanisms.
The cellular 3D printer of a marine bristle worm—chaetogenesis in Platynereis dumerilii (Audouin & Milne Edwards, 1834) (Annelida)
Authors: Tilic Ekin , Herkenrath Tim , Kirfel Gregor , Bartolomaeus Thomas
Published: December 2022

Annelid chaetae are extracellular chitinous structures that are formed in an extracellular epidermal invagination, the chaetal follicle. The basalmost cell of this follicle, the chaetoblast, serves like a 3D-printer as it dynamically shapes the chaeta. During chaetogenesis apical microvilli of the chaetoblast form the template for the chaeta, any structural details result from modulating the microvilli pattern. This study describes this process in detail in the model organismPlatynereis dumeriliiand clarifies some aspects of chaetogenesis in its close relativeNereis vexillosa, the first annelid in which the ultrastructure of chaetogenesis had been described. Nereid species possess compound chaetae characteristic for numerous subgroups of errant annelids. The distal most section of these chaetae is movable; a hinge connects this part of the chaeta to the shaft. Modulation of the microvilli and differences in their structure, diameter and number of microvilli, and their withdrawal and reappearance determine the shape of these compound chaetae. Chaetal structure and pattern also change during life history. While larvae possess a single type of chaeta (in addition to internal aciculae), juveniles and adults possess two types of chaetae that are replaced by large paddle-shaped chaetae in swimming epitokous stages. Chaetogenesis is a continuous process that lasts during the entire lifespan. The detailed developmental sequence of chaetae and their site of formation are very similar within species and species groups. We expect that similarity results from a conserved gene regulatory network making this an optimal system to test the phylogenetic affinity of taxa and the homology of their chaetae.
Psychotherapie und medikamentöse Behandlung
Authors: Löffler-Stastka Henriette , Zigic Nera , Bauer Martin
Published: December 2022

In der Gesamtbehandlungsplanung nimmt die Medikation unter spezifischen Gesichtspunkten eine spezielle Bedeutung ein. Individuelle, innerpsychisch-libidoökonomische, objektbeziehungstheoretische Konzepte werden entlang des Konzepts der „Resomatisierung“, des Handlungsdialogs, des Übergangsphänomens diskutiert. Krankheitsspezifische Bedeutungen bekommen anhand der Fallvignette Raum.
Heterogeneity, coordination and competition: the distribution of individual preferences in organisations
Authors: Jiménez-Jiménez Francisca
Published: December 2022

This paper experimentally investigates how inter- and intragroup heterogeneity (related to individual cooperative preferences) influences intergroup coordination. Coordination incentives are implemented through an intergroup rank-order competition. A pre-competition phase determines how individual heterogeneity is distributed across groups within an organisation. Two treatments are compared: a horizontal-heterogeneity treatment (H-Hetero, baseline), where individual differences are randomly distributed within and between groups, and a vertical-heterogeneity treatment (V-Hetero), in which groups are internally homogeneous but differ considerably from each other. In contrast to expectations, I find that vertical (intergroup) heterogeneity, when being accompanied by intragroup homogeneity, does not reduce the ability of groups to coordinate and keeps overall performance at very high levels. Indeed, subjects react more strongly to the coordination/competition incentives in vertically heterogenous organisations. Further analysis suggests that group dynamics are mainly driven by a positive orientation towards inequality (distributional preferences) of the members of the initially least cooperative groups, and their non-conditional cooperative behaviour. These results have implications for the design of group-based incentives and governance in organisations and societies.
The effects of low power laser light at 661 nm on wound healing in a scratch assay fibroblast model
Authors: Giannakopoulos Efstathios , Katopodi Annita , Rallis Michail , Politopoulos Konstantinos , Alexandratou Eleni
Published: December 2022

Wound treatment, especially for chronic and infected wounds, has been a permanent socio-economical challenge. This study aimed to investigate the ability of red light at 661 nm to accelerate wound healing an in vitro wound model using 3T3 fibroblasts. The purpose is further specified in clarifying the mechanisms of wound closure by means of intracellular ROS production, proliferation and migration of cells, and cellular orientation. Illumination effects of red light from a diode laser (661 nm) at different doses on 3T3 cell viability was assessed via MTT assay and tested in a scratch wound model. Wound closure rates were calculated by image analysis at 0, 24, and 48 h after laser treatment. ROS production was monitored and quantified immediately and 24 h after the treatment by fluorescence microscopy. Cellular orientation was quantified by image analysis. No phototoxic energy doses used and increased cell viability in most of the groups. Scratch assay revealed an energy interval of 3 – 4.5 J/cm2 that promote higher wound healing rate 24 h post treatment. An increase in ROS production was also observed 24 h post irradiation higher in the group with the highest wound healing rate. Also, cellular orientation toward the margin of the wound was observed and quantified after irradiation. Low power laser light at 661 nm activated both the migration and proliferation in the in vitro model used, providing evidence that it could also accelerate wound healing in vivo. Also, ROS production and cellular orientation seem to play an important role in wound healing process.
An effect of large-scale deletions and duplications on transcript expression
Authors: Mielczarek Magda , Frąszczak Magdalena , Zielak-Steciwko Anna E. , Nowak Błażej , Hofman Bartłomiej , Pierścińska Jagoda , Kruszyński Wojciech , Szyda Joanna
Published: December 2022

Since copy number variants (CNVs) have been recognized as an important source of genetic and transcriptomic variation, we aimed to characterize the impact of CNVs located within coding, intergenic, upstream, and downstream gene regions on the expression of transcripts. Regions in which deletions occurred most often were introns, while duplications in coding regions. The transcript expression was lower for deleted coding (P = 0.008) and intronic regions (P = 1.355 × 10−10), but it was not changed in the case of upstream and downstream gene regions (P = 0.085). Moreover, the expression was decreased if duplication occurred in the coding region (P = 8.318 × 10−5). Furthermore, a negative correlation (r =  − 0.27) between transcript length and its expression was observed. The correlation between the percent of deleted/duplicated transcript and transcript expression level was not significant for all concerned genomic regions in five out of six animals. The exceptions were deletions in coding regions (P = 0.004) and duplications in introns (P = 0.01) in one individual. CNVs in coding (deletions, duplications) and intronic (deletions) regions are important modulators of transcripts by reducing their expression level. We hypothesize that deletions imply severe consequences by interrupting genes. The negative correlation between the size of the transcript and its expression level found in this study is consistent with the hypothesis that selection favours shorter introns and a moderate number of exons in highly expressed genes. This may explain the transcript expression reduction by duplications. We did not find the correlation between the size of deletions/duplications and transcript expression level suggesting that expression is modulated by CNVs regardless of their size.
Factors associated with incidence of acute kidney injury: a Japanese regional population-based cohort study, the Shizuoka study
Authors: Dote Hisashi , Nakatani Eiji , Mori Kiyoshi , Sugawara Akira
Published: December 2022

Background

Acute kidney injury (AKI) is a globally critical issue. Most studies about AKI have been conducted in limited settings on perioperative or critically ill patients. As a result, there is little information about the epidemiology and risk factors of AKI in the general population.

Methods

We conducted a population-based cohort study using the Shizuoka Kokuho Database. We included subjects with records of health checkup results. The observation period for each participant was defined as from the date of insurance enrollment or April 2012, whichever occurred later, until the date of insurance withdrawal or September 2020, whichever was later. Primary outcome was AKI associated with admission based on the ICD-10 code. We described the incidence of AKI and performed a multivariate analysis using potential risk factors selected from comorbidities, medications, and health checkup results.

Results

Of 627,814 subjects, 8044 were diagnosed with AKI (incidence 251 per 100,000 person-years). The AKI group was older, with more males. Most comorbidities and prescribed medications were more common in the AKI group. As novel factors, statins (hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.80–0.89) and physical activity habits (HR 0.79, 95% CI 0.75–0.83) were associated with reduced incidence of AKI. Other variables associated with AKI were approximately consistent with those from previous studies.

Conclusions

The factors associated with AKI and the incidence of AKI in the general Japanese population are indicated. This study generates the hypothesis that statins and physical activity habits are novel protective factors for AKI.
Assessment of valve implantation in the descending aorta as an alternative for aortic regurgitation patients not treatable with conventional procedures
Authors: García-Galindo A. , Agujetas R. , López-Mínguez J. R. , Ferrera C.
Published: December 2022

Background:

Aortic Regurgitation (AR) produces the entrance of an abnormal amount of blood in the left ventricle. This disease is responsible for high morbidity and mortality worldwide and may be caused by an aortic valve dysfunction. Surgical and transcatheter aortic valve replacement (TAVR) are the current options for treating AR. They have replaced older procedures such as Hufnagel’s one. However, some physicians have reconsidered this procedure as a less aggressive alternative for patients not eligible for surgical or TAVR. Although Hufnagel suggested a 75% regurgitation reduction when a valve is placed in the descending aorta, a quantification of this value has not been reported.

Methods:

In this paper, CFD/FSI numerical simulation is conducted on an idealized geometry. We quantify the effect of placing a bileaflet mechanical heart valve in the descending aorta on a moderate-severe AR case. A three-element Windkessel model is employed to prescribe pressure outlet boundary conditions. We calculate the resulting flow rates and pressures at the aorta and first-generation vessels. Moreover, we evaluate several indices to assess the improvement due to the valve introduction.

Results and conclusions:

Regurgitation fraction (RF) is reduced from 37.5% (without valve) to 18.0% (with valve) in a single cardiac cycle. This reduction clearly shows the remarkable efficacy of the rescued technique. It will further ameliorate the left ventricle function in the long-term. Moreover, the calculations show that the implantation in that location introduces fewer incompatibilities’ risks than a conventional one. The proposed methodology can be extended to any particular conditions (pressure waveforms/geometry) and is designed to assess usual clinical parameters employed by physicians.
Fast satellite selection algorithm for GNSS multi-system based on Sherman–Morrison formula
Authors: Shi Junpeng , Li Kezhao , Chai Lin , Liang Lingfeng , Tian Chendong , Xu Keke
Published: December 2022

Efficient use of global navigation satellite system (GNSS) observations improves when applying rational satellite selection algorithms. By combining the Sherman–Morrison formula and singular value decomposition, a smaller-GDOP (geometric dilution of precision)-value method is proven for an increasing number of visible satellites. By combining this smaller-GDOP-value method with the maximum-volume-tetrahedron method, a new rapid satellite selection algorithm based on the Sherman–Morrison formula for GNSS multi-systems is proposed. The basic idea of the algorithm is as follows: First, the maximum-volume-tetrahedron method is used to obtain four initial visible satellites. Then, the other visible satellites are selected by using the smaller-GDOP-value method to reduce the GDOP value and improve the accuracy of the overall algorithm. When the number of included satellites reaches a certain value, the rate of GDOP decrease tends to approach zero. Considering the algorithm precision and the computation efficiency, reasonable thresholds and end of calculation condition equation are given, which can make the proposed algorithm autonomous. The reasonable thresholds and the end of calculation parameters are suggested by means of experiments. Under the thresholds and the end of calculation parameters, the algorithm has an adaptive functionality. Furthermore, the GDOP values of the algorithm are less than 2, indicating that this algorithm can meet one of the requirements of high-precision navigation. Moreover, compared with the computation complexity values of the optimal GDOP estimation method, which includes all visible satellites, the values of the new algorithm are about half, indicating that this algorithm has a rapid performance. These findings verify that the proposed satellite selection algorithm based on the Sherman–Morrison formula provides autonomous functionality, high-performance computing, and high-accuracy results.
From species detection to population size indexing: the use of sign surveys for monitoring a rare and otherwise elusive small mammal
Authors: Peralta Dinora , Vaz-Freire Teresa , Ferreira Clara , Mendes Tiago , Mira António , Santos Sara , Alves Paulo C. , Lambin Xavier , Beja Pedro , Paupério Joana , Pita Ricardo
Published: December 2022

Monitoring the occupancy and abundance of wildlife populations is key to evaluate their conservation status and trends. However, estimating these parameters often involves time and resource-intensive techniques, which are logistically challenging or even unfeasible for rare and elusive species that occur patchily and in small numbers. Hence, surveys based on field identification of signs (e.g. faeces, footprints) have long been considered a cost-effective alternative in wildlife monitoring, provided they produce reliable detectability and meaningful indices of population abundance. We tested the use of sign surveys for monitoring rare and otherwise elusive small mammals, focusing on the Cabrera vole (Microtus cabrerae) in Portugal. We asked how sampling intensity affects true positive detection of the species, and whether sign abundance is related to population size. We surveyed Cabrera voles’ latrines in 20 habitat patches known to be occupied, and estimated ‘true’ population size at each patch using DNA-based capture-recapture techniques. We found that a searching rate of ca. 3 min/250m2 of habitat based on adaptive guided transects was sufficient to provide true positive detection probabilities > 0.85. Sign-based abundance indices were at best moderately correlated with estimates of ‘true’ population size, and even so only for searching rates > 12 min/250m2. Our study suggests that surveys based on field identification of signs should provide a reliable option to estimate occupancy of Cabrera voles, and possibly for other rare or elusive small mammals, but cautions should be exercised when using this approach to infer population size. In case of practical constraints to the use of more accurate methods, a considerable sampling intensity is needed to reliably index Cabrera voles’ abundance from sign surveys.
fMRIflows: A Consortium of Fully Automatic Univariate and Multivariate fMRI Processing Pipelines
Authors: Notter Michael P. , Herholz Peer , Da Costa Sandra , Gulban Omer F. , Isik Ayse Ilkay , Gaglianese Anna , Murray Micah M.
Published: December 2022

How functional magnetic resonance imaging (fMRI) data are analyzed depends on the researcher and the toolbox used. It is not uncommon that the processing pipeline is rewritten for each new dataset. Consequently, code transparency, quality control and objective analysis pipelines are important for improving reproducibility in neuroimaging studies. Toolboxes, such as Nipype and fMRIPrep, have documented the need for and interest in automated pre-processing analysis pipelines. Recent developments in data-driven models combined with high resolution neuroimaging dataset have strengthened the need not only for a standardized preprocessing workflow, but also for a reliable and comparable statistical pipeline. Here, we introduce fMRIflows: a consortium of fully automatic neuroimaging pipelines for fMRI analysis, which performs standard preprocessing, as well as 1st- and 2nd-level univariate and multivariate analyses. In addition to the standardized pre-processing pipelines, fMRIflows provides flexible temporal and spatial filtering to account for datasets with increasingly high temporal resolution and to help appropriately prepare data for advanced machine learning analyses, improving signal decoding accuracy and reliability. This paper first describes fMRIflows’ structure and functionality, then explains its infrastructure and access, and lastly validates the toolbox by comparing it to other neuroimaging processing pipelines such as fMRIPrep, FSL and SPM. This validation was performed on three datasets with varying temporal sampling and acquisition parameters to prove its flexibility and robustness. fMRIflows is a fully automatic fMRI processing pipeline which uniquely offers univariate and multivariate single-subject and group analyses as well as pre-processing.
The best Condorcet-compatible election method: Ranked Pairs
Authors: Munger Charles T.
Published: December 2022

Condorcet-compatible election methods are examined and compared. The Ranked Pairs method proves significantly better than Beatpath; that both are clone-free, and have other desirable properties, makes them much better than any alternative.
Establishing severity levels for patient-reported measures of functional communication, participation, and perceived cognitive function for adults with acquired cognitive and language disorders
Authors: Cohen Matthew L. , Harnish Stacy M. , Lanzi Alyssa M. , Brello Jennifer , Hula William D. , Victorson David , Nandakumar Ratna , Kisala Pamela A. , Tulsky David S.
Published: December 2022

Purpose

To empirically assign severity levels (e.g., mild, moderate) to four relatively new patient-reported outcome measures (PROMs) for adults with acquired cognitive/language disorders. They include the Communicative Participation Item Bank, the Aphasia Communication Outcome Measure, and Neuro-QoL’s item banks of Cognitive Function (v2.0) and Ability to Participate in Social Roles and Activities (v1.0).

Method

We conducted 17 focus groups that comprised 22 adults with an acquired cognitive/language disorder from stroke, Parkinson’s disease, or traumatic brain injury; 30 care partners of an adult with an acquired cognitive/language disorder; and 42 speech-language pathologists who had experience assessing/treating individuals with those and other cognitive/language disorders. In a small, moderated focus-group format, participants completed “PROM-bookmarking” procedures: They discussed hypothetical vignettes based on PROM item responses about people with cognitive/language disorders and had to reach consensus regarding whether their symptoms/function should be categorized as within normal limits or mild, moderate, or severe challenges.

Results

There was generally good agreement among the stakeholder groups about how to classify vignettes, particularly when they reflected very high or low functioning. People with aphasia described a larger range of functional communication challenges as “mild” compared to other stakeholder types. Based on a consensus across groups, we present severity levels for specific score ranges for each PROM.

Conclusion

Standardized, stakeholder-informed severity levels that aid interpretation of PROM scores can help clinicians and researchers derive better clinical meaning from those scores, for example, by identifying important clinical windows of opportunity and assessing when symptoms have returned to a “normal” range.
An exposure to endocrine active persistent pollutants and endometriosis — a review of current epidemiological studies
Authors: Szczęsna Dorota , Wieczorek Katarzyna , Jurewicz Joanna
Published: December 2022

Widespread exposure to persistent pollutants can disrupt the bodies’ natural endocrine functions and contribute to reproductive diseases like endometriosis. In this review, we focus at the relationship between endocrine-disrupting chemicals (EDCs), including metals and trace elements, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), poly-brominated diphenyl ethers (PBDEs), polychlorinated dibenzodioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and per- and polyfluoroalkyl substances (PFAS) exposure and risk of endometriosis. Relevant studies from the last 10 years by November 2022 were identified by searching Pubmed, Web of Science, and Scopus. The cohort and case–control studies that reported effect size with 95% confidence intervals (CIs) of EDC exposure and endometriosis were selected. Twenty three articles examining the relationship between endometriosis and exposure to persistent EDCs were considered. Most of the studies indicated association with exposure to persistent chemicals and development of endometriosis. The consistent results were found in case of lead, PCB-28, PCB-138, PCB-153, PCB-180, PCB-201, 1,2,3,7,8 — PeCDD, 2,3,4,7,8 — PeCDF and all described OCPs, showing the increased risk of endometriosis. These results support that exposure to certain EDCs, including OCPs, PCBs, PBBs, PBDEs, PFAS, and lead increase the risk of endometriosis.
Adsorption of the hydrophobic organic pollutant hexachlorobenzene to phyllosilicate minerals
Authors: Böhm Leonard , Grančič Peter , Scholtzová Eva , Heyde Benjamin Justus , Düring Rolf-Alexander , Siemens Jan , Gerzabek Martin H. , Tunega Daniel
Published: December 2022

Hexachlorobenzene (HCB), a representative of hydrophobic organic chemicals (HOC), belongs to the group of persistent organic pollutants (POPs) that can have harmful effects on humans and other biota. Sorption processes in soils and sediments largely determine the fate of HCB and the risks arising from the compound in the environment. In this context, especially HOC–organic matter interactions are intensively studied, whereas knowledge of HOC adsorption to mineral phases (e.g., clay minerals) is comparatively limited. In this work, we performed batch adsorption experiments of HCB on a set of twelve phyllosilicate mineral sorbents that comprised several smectites, kaolinite, hectorite, chlorite, vermiculite, and illite. The effect of charge and size of exchangeable cations on HCB adsorption was studied using the source clay montmorillonite STx-1b after treatment with nine types of alkali (M+: Li, K, Na, Rb, Cs) and alkaline earth metal cations (M2+: Mg, Ca, Sr, Ba). Molecular modeling simulations based on density functional theory (DFT) calculations to reveal the effect of different cations on the adsorption energy in a selected HCB-clay mineral system accompanied this study. Results for HCB adsorption to minerals showed a large variation of solid–liquid adsorption constants Kd over four orders of magnitude (log Kd 0.9–3.3). Experiments with cation-modified montmorillonite resulted in increasing HCB adsorption with decreasing hydrated radii of exchangeable cations (log Kd 1.3–3.8 for M+ and 1.3–1.4 for M2+). DFT calculations predicted (gas phase) adsorption energies (− 76 to − 24 kJ mol−1 for M+ and − 96 to − 71 kJ mol−1 for M2+) showing a good correlation with Kd values for M2+-modified montmorillonite, whereas a discrepancy was observed for M+-modified montmorillonite. Supported by further calculations, this indicated that the solvent effect plays a relevant role in the adsorption process. Our results provide insight into the influence of minerals on HOC adsorption using HCB as an example and support the relevance of minerals for the environmental fate of HOCs such as for long-term source/sink phenomena in soils and sediments.
The dose-dependent effect of 1.5-GHz microwave exposure on spatial memory and the NMDAR pathway in Wistar rats
Authors: Wang Hui , Song Lequan , Zhao Li , Wang Haoyu , Xu Xinping , Dong Ji , Zhang Jing , Yao Binwei , Zhao Xuelong , Peng Ruiyun
Published: December 2022

A certain power of microwave radiation could cause changes in the nervous, cardiovascular, and other systems of the body, and the brain was a sensitive target organ of microwave radiation injury. Studies have shown that microwaves can impair cognitive functions in humans and animals, such as learning and memory, attention, and orientation. The dose-dependent effect of microwave radiation is still unclear. Our study aimed to investigate the effects of 1.5-GHz microwaves with different average power densities on locative learning and memory abilities, hippocampal structure, and related N-methyl D-aspartate receptor (NMDAR) signalling pathway proteins in rats. A total number of 140 male Wistar rats were randomly divided into four groups: S group (sham exposure), L5 group (1.5-GHz microwaves with average power density = 5 mW/cm2), L30 group (1.5-GHz microwaves with average power density = 30 mW/cm2), and L50 group (1.5-GHz microwaves with average power density = 50 mW/cm2). Changes in spatial learning and memory, EEG activity, hippocampal structure, and NMDAR signalling pathway molecules were detected from 6 h to 28 d after microwave exposure. After exposure to 1.5-GHz microwaves, rats in the L30 and L50 groups showed impaired spatial memory, inhibited EEG activity, pyknosis and hyperchromatism of neuron nucleus, and changes in NMDAR subunits and downstream signalling molecules. In conclusion, 1.5-GHz microwaves with an average power density of 5, 30, and 50 mW/cm2 could induce spatial memory dysfunction, hippocampal structure changes, and changes in protein levels in rats, and there was a defined dose-dependent effect.
Network Analysis of the Structure of the Core Symptoms and Clinical Correlates in Comorbid Schizophrenia and Gambling Disorder
Authors: Granero Roser , Fernández-Aranda Fernando , Demetrovics Zsolt , Lara-Huallipe Milagros , Morón-Fernández Alex , Jiménez-Murcia Susana
Published: December 2022

Few studies have analyzed the clinical profile of treatment-seeking patients with the comorbid presence of schizophrenia (SCZ) and gambling disorder (GD), which warrants new research to assess the network structure of this complex mental condition. The aim of this study was to explore the organization of the symptoms and other clinical correlates of SCZ with GD. Network analysis was applied to a sample of N = 179 SCZ patients (age range: 19–70 years, mean=39.5, SD=9.9) who met clinical criteria for gambling disorder-related problems. Variables included in the network were the core GD symptoms according to the DSM-5, psychotic and paranoid ideation levels, global psychological distress, GD severity measures (debts and illegal behavior related with gambling), substances (tobacco, alcohol, and illegal drugs), and personality profile. The nodes with the highest authority in the network (variables of highest relevance) were personality traits and psychological distress. Four empirical modules/clusters were identified, and linkage analysis identified the nodes with the highest closeness (bridge nodes) to be novelty seeking and reward dependence (these traits facilitate the transition between the modules). Identification of the variables with the highest centrality/linkage can be particularly useful for developing precise management plans to prevent and treat SCZ with GD.
BDNF Val66Met Polymorphism: Suggested Genetic Involvement in Some Children with Learning Disorder
Authors: Elhadidy Mohamed E. , Kilany Ayman , Gebril Ola Hosny , Nashaat Neveen Hassan , Zeidan Hala M. , Elsaied Amal , Hashish Adel F. , Abdelraouf Ehab Ragaa
Published: December 2022

Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal survival, especially in areas responsible for memory and learning. The BDNF Val66Met polymorphism has been described as a cognitive modifier in people with neuropsychiatric disorders. BDNF levels have been found to be low in children with learning disorder (LD). However, Val66Met polymorphism has not been studied before in such children. The aim was to investigate the presence of BDNF val66Met polymorphism in a group of children with specific LD and to verify its impact on their cognitive abilities. The participants in this cross-sectional study (N = 111) were divided into two groups: one for children with LD and the other for neurotypical (NT) ones. Children with LD (N = 72) were diagnosed according to the DSM-5 criteria. Their abilities were evaluated using Stanford–Binet Intelligence Scale, dyslexia assessment test, Illinois Test of Psycholinguistic Abilities, and phonological awareness test. Genotyping of BDNF Val66Met polymorphism was performed for all participants. The frequency of the Met allele was 26% among children with LD (6 children had homozygous, 26 had heterozygous genotype). The percentage of participants with deficits in reading, writing, and phonemic segmentation was higher in Met allele carriers when compared to non-Met allele carriers in LD group. The frequency of Met allele among NT children was 3.85% (0 homozygous, 3 children had heterozygous genotype) (p = 0.00001). The high frequency of Val66Met polymorphism among children with LD introduces the BDNF gene as a genetic modifier of learning performance in some children who manifest specific learning disorder (developmental dyslexia).