bluuebunny/crossref_metadata_2025 huggingface dataset:
Degradation of Sodium Acetate by Catalytic Ozonation Coupled with a Mn-Functionalized Fly Ash: Reaction Parameters and Mechanism
Authors: Chen Yaoji , Chen Ruifu , Chang Xinglan , Yan Jingying , Gu Yajie , Xi Shuang , Sun Pengfei , Dong Xiaoping
Published: August 2023

Supported ozone catalysts usually take alumina, activated carbon, mesoporous molecular sieve, graphene, etc. as the carrier for loading metal oxide via the impregnation method, sol–gel method and precipitation method. In this work, a Mn-modified fly ash catalyst was synthesized to reduce the consumption and high unit price of traditional catalyst carriers like alumina. As a solid waste discharged from coal-fired power plants fueled by coal, fly ash also has porous spherical fine particles with constant surface area and activity, abd is expected to be applied as the main component in the synthesis of ozone catalyst. After the pretreatment process and modification with MnOx, the obtained Mn-modified fly ash exhibited stronger specific surface area and porosity combined with considerable ozone catalytic performance. We used sodium acetate as the contaminant probe, which is difficult to directly decompose with ozone as the end product of ozone oxidation, to evaluate the performance of this Mn-modified fly. It was found that ozone molecules can be transformed to generate ·OH, ·O2− and 1O2 for the further oxidation of sodium acetate. The oxygen vacancy produced via Mn modification plays a crucial role in the adsorption and excitation of ozone. This work demonstrates that fly ash, as an industrial waste, can be synthesized as a potential industrial catalyst with stable physical and chemical properties, a simple preparation method and low costs.
Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine
Authors: Mahant Aakash Mahant , Gromisch Matthew S. , Kravets Leah , Burn Aschner Clare , Herold Betsy C.
Published: August 2023

Herpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting glycoprotein D (gD), failed to provide durable protection. We adopted a different strategy and evaluated a single-cycle virus deleted in gD (ΔgD-2). ΔgD-2elicits antibodies that primarily mediate antibody-dependent cell mediated cytolysis (ADCC) and provides complete protection against clinical isolates of HSV in multiple lethal mouse models. To assess durability, we vaccinated mice (2 doses administered intramuscularly) with ΔgD-2, adjuvanted recombinant gD-2 (rgD-2/Alum-MPL), or uninfected cells as a control, and quantified antibody responses over one year. Mice (n = 5/group) were lethally challenged at 2, 4, 6, 8, and 10-months post-boost. ΔgD-2-vaccinated mice elicited a durable ADCC-mediating response, which provided complete protection against challenge at all timepoints. In contrast, rgD-2/Alum-MPL elicited only nAbs, which declined significantly within 6 months, provided only partial protection at early timepoints, and no protection after 6 months. Serum sampling after viral challenge showed that infection elicited low levels of ADCC-mediating antibodies in rgD-2/Alum-MPL-vaccinated mice and boosted the nAb response, but only after 6 months. Conversely, infection significantly and consistently boosted both the ADCC and nAbs responses in ΔgD-2-vaccinated mice. Results recapitulate clinical trial outcomes with gD vaccines, highlight the importance of ADCC, and predict that ΔgD-2 will elicit durable responses in humans.
Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71
Authors: Tan Xiu , Chong Wei , Lee Vannajan , Abdullah Syahril , Jasni Kartini , Suarni Saiful , Perera David , Sam I-Ching , Chan Yoke
Published: August 2023

Hand, foot and mouth disease (HFMD) is a childhood disease caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Capsid loops are important epitopes for EV-A71 and CV-A16. Seven chimeric EV-A71 (ChiE71) involving VP1 BC (45.5% similarity), DE, EF, GH and HI loops, VP2 EF loop and VP3 GH loop (91.3% similarity) were substituted with corresponding CV-A16 loops. Only ChiE71-1-BC, ChiE71-1-EF, ChiE71-1-GH and ChiE71-3-GH were viable. EV-A71 and CV-A16 antiserum neutralized ChiE71-1-BC and ChiE71-1-EF. Mice immunized with inactivated ChiE71 elicited high IgG, IFN-γ, IL-2, IL-4 and IL-10. Neonatal mice receiving passive transfer of WT EV-A71, ChiE71-1-EF and ChiE71-1-BC immune sera had 100%, 80.0% and no survival, respectively, against lethal challenges with EV-A71, suggesting that the substituted CV-A16 loops disrupted EV-A71 immunogenicity. Passive transfer of CV-A16, ChiE71-1-EF and ChiE71-1-BC immune sera provided 40.0%, 20.0% and 42.9% survival, respectively, against CV-A16. One-day-old neonatal mice immunized with WT EV-A71, ChiE71-1-BC, ChiE71-1-EF and CV-A16 achieved 62.5%, 60.0%, 57.1%, and no survival, respectively, after the EV-A71 challenge. Active immunization using CV-A16 provided full protection while WT EV-A71, ChiE71-1-BC and ChiE71-1-EF immunization showed partial cross-protection in CV-A16 lethal challenge with survival rates of 50.0%, 20.0% and 40%, respectively. Disruption of a capsid loop could affect virus immunogenicity, and future vaccine design should include conservation of the enterovirus capsid loops.
The Human Ecology of Overshoot: Why a Major ‘Population Correction’ Is Inevitable
Authors: Rees William E.
Published: August 2023

Homo sapiens has evolved to reproduce exponentially, expand geographically, and consume all available resources. For most of humanity’s evolutionary history, such expansionist tendencies have been countered by negative feedback. However, the scientific revolution and the use of fossil fuels reduced many forms of negative feedback, enabling us to realize our full potential for exponential growth. This natural capacity is being reinforced by growth-oriented neoliberal economics—nurture complements nature. Problem: the human enterprise is a ‘dissipative structure’ and sub-system of the ecosphere—it can grow and maintain itself only by consuming and dissipating available energy and resources extracted from its host system, the ecosphere, and discharging waste back into its host. The population increase from one to eight billion, and >100-fold expansion of real GWP in just two centuries on a finite planet, has thus propelled modern techno-industrial society into a state of advanced overshoot. We are consuming and polluting the biophysical basis of our own existence. Climate change is the best-known symptom of overshoot, but mainstream ‘solutions’ will actually accelerate climate disruption and worsen overshoot. Humanity is exhibiting the characteristic dynamics of a one-off population boom–bust cycle. The global economy will inevitably contract and humanity will suffer a major population ‘correction’ in this century.
Treatment of stuttering in children and adolescents in the conditions of a day hospital
Authors:   SBHI Samara Regional Clinical Psychiatric Hospital, Samara, Russia, Shlyapkina O. Yu. , Soshnikova N. V. ,   SBHI Samara Regional Clinical Psychiatric Hospital, Samara, Russia
Published: August 2023

The article presents a comprehensive approach to the treatment of stuttering in children and adolescents in a day hospital with the direct participation of nursing staff in this process. Aim. Providing information on the organization of the process of providing assistance to children and adolescents with stut tering in the SBHI Samara Regional Clinical Psychiatric Hospital. Results. Applying this comprehensive approach, in the vast majority of cases, it is possible to achieve high results in relieving patients of stut tering at the end of treatment. Conclusion. Treatment of stuttering is one of the important areas of work of the psychiatric service, aimed at social, mental, and physical prevention in the child and adolescent population.
Problems of ensuring economic security of multilevel logistics systems
Authors:   Belarusian National Technical University, Minsk, Ivut R.B. , Lapkovskaya P.I. ,   Belarusian National Technical University, Minsk
Published: August 2023

Safety is one of the most important indicators of the quality of the logistics system functioning. This article presents the developed tree of goals for ensuring the economic security of multilevel logistics systems in industry and transport; a list of indicators of the economic security of macro-logistics systems of the EAEU countries is proposed.
REGIONAL FLORA OF ROSLYN POLTAVA REGION THAT SPECIFICS
Authors: Hapon S. , Hapon Y. , Khannanova O. , Ischenko V.
Published: August 2023

The work describes the flora of higher sporeless vascular plants (superdivision Bryobionta, divisions Marhantiophyta, Bryophyta) and higher spore vascular plants (divisions Lycopodiophyta, Equisetophyta, Psilotophyta, Polypodiophyta) of Poltava region, analyzed the peculiarities of its systematic and taxonomic composition. As a result of research, it was established that the bryobiont flora includes 167 species, 87 genus, and 43 families. Lycopodiophyta – five species from four genus, two families, Equisetophyta – 9 species from one genus, one family, Psilotophyta – 2 species from 2 genus, 2 families, Polypodiophyta – 14 species from 11 genus, 7 families. The department Marchantiophyta is represented by 17 species from 11 genus, 9 families, Bryophyta – 150 species, 75 genus, 33 families. In general, according to the results of research, it was found that the flora of spore plants of the Poltava region includes 197 species from 104 genus, 55 families.It was established that there are 70 rare and endangered species in the studied flora (36.46% of the total number). Among bryophytes, there are 49 species (29.3% of the total number). One of them is Tortula randii (Kenn.) R.H. Zander – listed in the Red Book of Ukraine, Dicranum viride (Kenn.) R.H. Zander – in the European Red List, the rest – 47 species are regionally rare. Among the representatives of the division Lycopodiophyta, three species are listed in the Red Book of Ukraine (Diaphasiastrum complanatum (L.) Holub., Lycopodium annotinum L., Lycopodiella denudata (L.) Holub., Huperzia selago (L.) Bernh. ex Schrank et Mart.), one species, Lycopodium clavatum, is regionally rare. Among Equisetophyta, 4 species are included in the regional list, Psilotophyta – Botrychium lunaria (L.) Sw. – in the Red Book of Ukraine, Ophioglossum vulgatum L. – in the regional list, Polypodiophyta – Salvinia natans (L.) All., – in the Red Book of Ukraine, 10 species – to the regional list.
CHOROLOGY OF SPECIES OF THE FAMILY RANUNCULACEAE JUSS. FROM «THE RED DATA BOOK OF UKRAINE» ON THE TERRITORY OF POLTAVA REGION
Authors: Davydov D. , Gomlya L.
Published: August 2023

Based on results of the analysis of herbarium collections, data from online-resources iNaturalist and UkrBIN and various literature sources information about the distribution of six plant species from the family Ranunculaceae Juss. with national conservation level included in «The Red Data Book of Ukraine» on the territory of Poltava region were summarized. Four species (Adonis vernalis L., A. volgensis DC., Pulsatilla patens (L.) Mill., P. pratensis (L.) Mill.) were realibly found there, other two species (Delphinium cuneatum Spreng. and Pulsatilla grandis Wend.) have been indicated based on literature sources only and their presence needs confirmation. In our opinion, Pulsatilla grandis were erroneously indicated for Poltava region and its locations belong to two other species from this genus. The most distributed species based on number of known localities are Adonis vernalis L. (128 locations) and Pulsatilla pratensis (L.) Mill. (75). List of known localities and data about the distribution in administrative districts and amalgamated territorial communes are indicated for all species. Nomenclatural problems of several rare plant species were discussed: the name Adonis volgensis DC. is proposed to use against A. wolgensis Steven, and the name Delphinium cuneatum Spreng. – against D. rossicum Litv. The new nomenclatural combination Pulsatilla pratensis subsp.ucranica (Ugr.) Davydov was proposed and its lectotype has been firstly indicated. The significant role of online open data resources during the research of the biodiversity of Ukraine is also emphasized, these resources are convenient tool for the monitoring and summarizing available data about typical and rare species of our flora and fauna.
INFLUENCE OF BIOSTIMULATORS ON SEED QUALITY AND GROWTH PROCESSES OF BEANS CROPS
Authors: Shevchuk O. , Polyvanyi S. , Khodanitska O. , Tkachuk O.
Published: August 2023

It was studied the effect of biostimulants Trichodermin-Bio, Epin-extra, Zircon and Krezatsin on laboratory seed germination and growth processes of legumes: fodder beans of the Vizir variety, chickling vetch (grass pea, chickling pea) of the Ivolga variety, and food lentils of the Linza variety.The use of biostimulants in legumes caused an increase in the sowing qualities of seeds and their biometric characteristics.The use of Epin-extra biostimulator gave the best effect. This preparation improved the germination energy of seeds of fodder beans, chickling vetch, and food lentils by 1–8 %, laboratory germination by 2–3 %, and germination simultaneity by 1,8–3,9 %.Pre-sowing treatment of seeds with biostimulator Epin-extra led to an increase in seedling weight by 0,03–0,04 g compared to water treatment in the control.
HISTORY OF THE ISSUE OF FORMATION INTERNATIONAL ANATOMICAL TERMINOLOGY
Authors: Sherstiuk O. , Svintsytska N. , Bilash V. , Hryn V. , Ustenko R. , Katsenko A. , Korchan N.
Published: August 2023

The historical milestones of the development of international anatomical terminology are considered.The works in which already in the Homeric epoch it is possible to find a number of anatomical and nosological names which were used by Hippocrates and which are used in modern medical science are analyzed. The key role of bright historical figures who have made a huge invaluable contribution to the development, formation and formation of the international anatomical nomenclature is highlighted.In turn, such a long-awaited list of Latin, Ukrainian and English equivalents of anatomical terms in the latest Latin-English and Ukrainian anatomical nomenclature should contribute to the optimal integration of modern Ukrainian medicine into a single global scientific and educational space. The need to involve a number of measures to promote the systematic updating of terminological knowledge, interdisciplinary integration of knowledge gained in Latin and morphological departments, improving the anatomical and clinical terminological literacy of not only students but also health professionals.
SYSTEMATIC STRUCTURE OF FLORA OF MEADOWS OF THE ROMENSKO-POLTAVSKY GEOBOTANICAL DISTRICT
Authors: Zhuk M.
Published: August 2023

The systematic structure of the meadows flora of the Romensko-Poltavsky geobotanical district was analyzed in this article. As a result of the study, the species composition of the flora, which includes 601 species belonging to 306 genera, 66 families, 41 orders, 3 classes, 2 divisions, were revealed. Magnoliophyta is the dominant division, as it includes 598 (98,5%) species, 305 (99,7%) genera, and 65 (98,5%) families. Among the leading families in terms of types of researched meadows there are Asteraceae (113 species, 18,8%), Poaceae (67 species, 11,1%), Fabaceae (45 species, 7,5%), Lamiaceae (36 species, 6%), Caryophyllaceae (29 species, 4,8%), Scrophulariaceae (26 species, 4,3%), Brassicaceae (25 species, 4,2%), Cyperaceae (24 species, 4%), Rosaceae (23 species, 3,8%), Ranunculaceae (22 species, 3,7%), which add up together 310 species and it is 68,2% of the total number of species. The first three families contain 225 species, which make up 37,4% of the total number of species. Among the leading families in terms of genera of the flora of the Romensko-Poltavsky geobotanical district meadows are Asteraceae (51 genera, 16,6%), Poaceae (38 genera, 12,4%), Lamiaceae (19 genera, 6,2%), Fabaceae (17 genera, 5,5%), Brassicaceae (17 genera, 5,5%), Apiaceae (16 genera, 5,2%), Caryophyllaceae (16 genera, 5,2%), Rosaceae (13 genera, 4,2%), Ranunculaceae (10 genera, 3,2%), Scrophulariaceae (9 genera, 2,9%), which together contain 206 genera and it is 66,9% of the total number of genera. The first three families have 108 genera, which is 35,2% of the total number. The leading genera include Carex L. (16 species, 5,2%), Ranunculus L., Trifolium L., Veronica L. (9 species each, 2,9%), Festuca L., Galium L. (8 species each, 2,6%), Artemisia L., Centaurea L., Cirsium Mill., Inula L., Juncus L., Plantago L., Poa L., Vicia L. (7 species each, 2,3%), which together number 108 species out of 601 and constitute 37,5% of the total number of detected species. By species saturation, Carex L. is the only polymorphic one, but 281 genera (91,9%) belong to poor and monotypic genera, which have 428 species, which make up 71,2% of the total number of species. The meadows flora of the Romensko-Poltavsky geobotanical district has similar results with the floras meadows of the Left Bank Forest Steppe, vascular plants of the Left Bank Dnieper and fodder lands of the Forest Steppe of Ukraine by the spectra of the leading families by species, genera and leading genera.
INTRODUCTORY SEARCH AND MOBILIZATION OF PRUNUS DULCIS (MILL.) D.A.WEBB SPECIMENS FOR RESEARCH IN KHOROL BOTANICAL GARDEN
Authors: Krasovsky V. , Gapon S. , Cherniak T.
Published: August 2023

The Khorol Botanical Garden is presented as a point of introduction of subtropical fruit plants, where Prunus dulcis (Mill.) D.A. Webb occupies a prominent place among the studied species, since the value of the stone core of this culture is widely known.

Odesa, Zaporizhzhya and Cherkasy regions are shown as regions for the selection of introduction material, because in the last decade, thanks to the activities of the NGO «Ukrainian Walnut Association» and amateur gardeners, P. dulcis has become increasingly widespread.

The expediency of selecting cultivars according to their description is substantiated, because the determining feature is the average and late flowering of plants, since in the conditions of the forest-steppe of Ukraine, early flowering ones can suffer from reverse frosts, which significantly affects the yield of the crop.

The results of the search for P. dulcis for the mobilization of samples to the Khorol Botanical Garden are highlighted. It was established that in the steppe zone of Ukraine, a significant number of varieties of Ukrainian and foreign selection programs are cultivated, which bear fruit every year and form full seeds. The high adaptation of cultivars, their plasticity and winter resistance was shown, which made it possible to identify and mobilize samples of the following mid- and late-flowering varieties and forms: ‘Amaretto’, ‘Papershell’, ‘Vairo’, ‘Victoria’, ‘Dessertny’, ‘Meteor’, Pervenets Khramov’, ‘Foros’, ‘E5 Borozan’, ‘M 41 Alex’, ‘Ferragnès’, ‘Fentsia’, ‘Thin-skinned’, forms 9-A,1-D, 3-E, F–37 ‘Louise’ , F–58–12 ‘Paper’, № 1 (weeping), № 2, F–48.

It is noted that the collected collection of P. dulcis samples will be further investigated for pollination with the establishment of differentiation between self-incompatible and self-compatible varieties and forms.

It is emphasized that self-incompatible varieties, while producing viable pollen and ovules, are unable to fertilize the seed primordia of the same variety and, as a result, produce a harvest. Because of this, the presence of two or more varieties in a separate garden is necessary to ensure the transfer of pollen from the anthers of the flowers of one variety to the receptacles of the flowers of another. Insufficient pollination is a real loss of yield, so to ensure a good level of yield, the maximum number of flowers must be pollinated. In P. dulcis, the reduction in fruit number resulting from any pollination problem is rarely offset by the increase in fruit size and weight that occurs in other fruit crops.
THEORETICAL FOUNDATIONS OF FORMING A COLLECTION OF SUBTROPICAL FRUIT CROPS BASED ON THE AGROBIOSCIENCE STATION OF THE V.G. KOROLENKO POLTAVA NATIONAL PEDAGOGICAL UNIVERSITY
Authors: Orlovskyi O.
Published: August 2023

The results of studying the features and developing the establishment of a collection of subtropical fruit crops in open field conditions based on the agro-bioscience station of the V. G. Korolenko Poltava National Pedagogical University are presented. The theoretical foundations and recommendations regarding the peculiarities of wintering and collection formation in the conditions of a moderate climate of the forest-steppe of Ukraine are considered. A number of previously successfully introduced crops are identified, their species composition is characterized, and a series of factors that affect or may affect the further introduction process are established.

The idea of creating an introduction point with the formation of the main collection, which will include species such as Asimina triloba L., Zizyphus jujuba Mill., Punica granatum L., Ficus carica L., Diospyros virginiana L., Cydonia oblonga Mill., Prunus dulcis Mill., Mespilus germanica L., and Chaenomeles japonica Lindl., is put forward.
BRYOPHYTES OF THE NATURE MONUMENT OF NATIONAL IMPORTANCE «TEPLA JAMA» WITHIN THE VOLCANIC CARPATHIANS (UKRAINE)
Authors: Felbaba-Klushina L. , Virchenko V. , Sadygov R.
Published: August 2023

Among all floristic regions of the Ukrainian Carpathians, the Volcanic Carpathians remain relatively poorly studied in terms of bryological research, and the objects of the low-ranking natural reserve fund are almost not covered by floristic investigations. As a result of our research, 60 species of bryophytes were revealed on the territory of the botanical natural monument of local importance «Tepla Yama», which is about 10% of the bryoflora diversity of the Ukrainian Carpathians as a whole. It was found out that in the taxonomic spectrum of bryophytes, the orders Bryales and Hypnales are the richest. The mosses (Bryophyta) are represented by 2 classes, 8 orders, 24 families, 45 genera and 52 species. The species richness of the families Orthotrichaceae (9 species), Brachytheciaceae (6), Neckeraceae and Amblystegiaceae (by 4), Polytrichaceae and Dicranaceae (by 3 species) reflects the general features of the bryoflora structure of the Ukrainian Carpathians. Epiphytes dominate in terms of substrate preference, which is a characteristic feature of bryophytes in broad-leaved forests. The low amount of decaying wood at this stage of forest phytocenosis development is the reason for the small number of epixylic bryophytes. Several rare montane species were found, occurring mainly in primeval and slightly disturbed forests of the Carpathians and Crimea. Among them are Metzgeria conjugata, Zygodon rupestris, Zygodon viridissimus, Ctenidium molluscum, Grimmia hartmanii, as well as Dicranum viride, which occasionally occurs on the plains and is included in the Red Book of bryophytes of Europe (Hodgest, Lockhart, 2020). Therefore, despite the close location of this forest massif to populated areas and its easy accessibility for tourists, it remains a natural center of a significant diversity of bryophytes, including montane species that are rare in Ukraine. Our research has initiated the monitoring of species diversity of this organism group, which will allow forecasting the development of this forest biogeocenosis in the future.
PECULIARITIES OF ONTOGENY OF HERACLEUM MANTEGAZZIANUM SOMMIER & LEVIER. ON THE TERRITORY OF KAMENETZ REGION
Authors: Korsun O.
Published: August 2023

The article deals with the peculiarities of the ontogeny of plants of the Heracleum mantegazzianum Sommier & Levier species. The sequence of the ontogenetic cycle of plants is analyzed and characterized. The age spectra of H. mantegazzianum populations in the Kamianets region were studied. To study the ontogenetic structure of populations, 5 experimental plots of10 m2 were laid out. It was established that the ontogeny of H. mantegazzianum is represented by6 ontogenetic states: seedlings (p), juveniles (j), imatures (im), virgin (v), generative (g) and senescents (s). According to the ontogenetic structure, the cenopopulations of all plots are characterized as normal, full-membered. The maximum of the age spectrum falls on seedlings (73,7%, site 3). The age spectrum of all studied populations was determined as left-handed, probably due to the high seed productivity of the species. The average population density for each study site was determined. The analysis showed that the average density varies from 12 to 17 individuals per 1 m2. The highest number of plants was observed in plots 3 and 5, while in other plots the ratio of the number of plants is relatively the same.
АNALYSIS OF THE STRUCTURE OF THE INTRAHEPATIC BILE DUCTS OF MAMMALS WITH A MIXED TYPE OF NUTRITION
Authors: Dubinin D. , Shepitko V. , Dubinin S. , Stetsuk Ye. , Boruta N. , Vilkhova O. , Ulanovskaya-Tsiba N.
Published: August 2023

Diseases of the biliary system, such as cholecystitis of various etiologies, gallstone disease, post-cholecystectomy syndrome and cholangitis, are becoming more common. Every tenth representative of adult population suffers from gallstone disease. This disease is widespread in various countries of the world, and the number of patients is increasing. An increase in the incidence of the biliary system has been noted in all economically developed countries, and women with this pathology are a several times more common case than men.

The wall of the intrahepatic bile duct is represented by outer adventitia and inner mucosa. In the initial sections of the excretory system of the liver, bile ducts in the mucous membrane are represented by epithelial tissue with a basement membrane, which ensures the physiological regeneration of this layer. The middle section of the biliary system of the liver is almost no different from the structure in the initial sections. There are still some differences in the structure of the inner shell. Other forms of epitheliocytes are observed. Not only cubic, but also prismatic epitheliocytes are found in intrahepatic bile ducts. The nuclei, which are mainly located near the basal surface, have some differences in the location. But there are also those in which the nucleus is located in the center of the cell. The department of the intrahepatic bile duct, which is the closest to the gate of the liver, has differences in diameter and in the number of cells of the inner lining. Epitheliocytes have a prismatic structure, and the nuclei are mainlylocated on the basal surface and have an elongated shape. The outer shell, in which there are cells of the fibroblastic series and an intercellular substance with collagen fibers and an amorphous substance, remains unchanged.
AESTHETIC DIMENSIONS OF IVAN ZIAZIUN’S PEDAGOGICAL HERITAGE
Authors: Solomakha S.
Published: August 2023

The article examines various aspects of the philosophical, pedagogical, and ethical-aesthetic ideas of academician Ivan Andriyovych Ziaziun, which occupy a significant place in his multifaceted scientific heritage. According to I. Ziaziun, the philosophical categories of “goodness”, “beauty” and “freedom” always stand for Truth, which embodies the deep meaning of human worldview and comprehension of existence, the search for the human spirit, and the creation of humanistic ideals. The categories of aesthetics, aesthetic education, pedagogical skills, pedagogical action of a teacher, and spiritual development of an individual through the Beauty captured in art play an essential role in the professional growth of teachers.

It is advisable to study the scientific heritage of the outstanding Ukrainian scientist and teacher I. Ziaziun, looking for ways to implement his ideas in modern pedagogical practice. As Ivan Andriyovych convincingly proves, aesthetic values of consciousness concentrate humanistic ideals, goals, motives, intentions, and moods that determine the position and behavior of a teacher, positively impact the humanistic orientation of an organization of pedagogical actions of lecturers and teachers, are the basis for the development and improvement of the subjective-emotional component of consciousness – the value knowledge of both those who teach and those who study. According to I. Ziaziun, the issues of aesthetics and ethics, pedagogical education, and aesthetic education should be significant components of the national cultural policy and national education of young people, as they are the basis for the spiritual development of an individual.
DEVELOPMENT OF ACADEMIC PARTNERSHIP IN MILITARY REALITIES ON THE BASIS OF UNIVERSITY OF PISA ETHICAL VALUES
Authors: Semenoh O. , Bilichenko O.
Published: August 2023

The article outlines the aspects of the development of future philologists’ academic partnership culture in Ukrainian universities in wartime realities based on the ethical values of the European experience, the University of Pisa (UNIPI, Italy) in particular.

Valuable practices of the Department of Philology, Literature, and Linguistics of the University of Pisa (Italy) on academic culture and ethics development are presented. The article co-author is undergoing an internship as a visiting professor under the program of research support of the European Research Space of Ukrainian Universities in wartime realities.

Valuable practices for the development of academic culture and ethics at the University of Pisa include the following: fundamental principles and values of the university community, cultural and professional development of participants in the educational process, respect for learning, teaching, and evaluation, closely connected with research, ethical rules of academic communication in the scientific and educational community, problem lectures, seminars, symposium-discussions, workshops, problem-oriented research colloquiums.

The course of joint events in wartime conditions for students, master’s students of philology of Donbas State Pedagogical University, and Sumy A.S. Makarenko State Pedagogical University based on the ethical values of the University of Pisa.

The methodology for the formation of the academic culture of future teacher-researchers in Ukrainian pedagogical universities is designed taking into account the valuable practices of the Department of Philology, Literature and Linguistics of University of Pisa, which relate to the integration of the content of educational disciplines, the use of active, interactive and collaborative teaching methods and techniques; development of research laboratories for academic communication.

Attention is focused on the principles of academic ethics in teaching and learning processes, which includes the following postulates: reliability in ensuring the quality of scientific research; honesty in the development, execution, review, and publication of research in a transparent manner; respect for participants in the research process; responsibility for research from idea to publication, scientific guidance, and mentoring, etc.
NATIONAL IDENTITY OF THE SPECIALIST BASED ON MUSIC PEDAGOGICS OF O. P. RUDNYTSKA
Authors: Bilyk N.
Published: August 2023

The review article analyzes the peculiarities of the national identity of Oksana Petrivna Rudnytska, a specialist in music pedagogy. The logic of the scientific content of the terms related to the topic of the submitted article (identity, national identity; professional and artistic competence; scientific school) is revealed. The article considers national identity as a sphere of ideas, values, and meanings of culture, perceived and articulated by the majority of the country's citizens. It has its own principles in the individual's construction of his identity, belonging to a definite nation and state. Certain issues regarding the effectiveness of the scientific schools of Ivan Zyazyun Institute of Pedagogical and Adult Education of the National Academy of Sciences of Ukraine, in particular the Ukrainian scientist, Doctor of Pedagogical Sciences, Professor O. P. Rudnytska, are highlighted. A conclusion is made regarding the results of the scientist's activity in relation to her national identity as a specialist in music pedagogy, which is based on the values of pedagogical mentoring, intellectual leadership, empathy, and national ethical and aesthetic worldview guidelines.

Based on the vast experience of a teacher-artist, we can help increase the level of formation of the professional competence of music teachers and guarantee quality training of future music teachers for pedagogical and artistic activities.
THE INFLUENCE OF EDUCATIONAL ENVIRONMENT ON THE DEVELOPMENT OF FUTURE DESIGNERS’ CREATIVITY
Authors: Paziura N.
Published: August 2023

This scientific article is aimed at studying the problem of fostering creativity in future designers in the context of labour market requirements and taking into account the latest trends in design. The analysis of modern approaches to the educational process in the field of design at the institutional level and the compliance of educational services with the needs of the labor market was carried out. It was found that the creative educational environment of the educational institution best contributes to the development of creativity in future designers. The determining factors of the educational environment are revealed. It has been proven that educating students in a creative educational environment affects their creativity and further motivation for success. A conclusion was made about the need to create a creative and innovative educational environment in educational institutions.
TERMINOLOGICAL DISCOURSE OF THE ISSUE OF PREPARING FUTURE BACHELORS OF GRAPHIC DESIGN FOR CALLIGRAPHY USAGE IN PROFESSIONAL ACTIVITIES
Authors: Shpak O.
Published: August 2023

The review article presents the terminological discourse of the issue of training future bachelors of graphic design for calligraphy usage in professional activities, which includes such terms as “art education,” “design-education,” “design,” “graphic design,” “calligraphy,” “font,” “font design,” “national font design,” etc. The essence of design as a form of art aimed at the artistic construction of the subject space by applying the potential of artistic and industrial production, decorative and applied art with the aim of aestheticizing everyday life, the professional environment on the basis of national, ethnic, cultural identity has been clarified. The analysis of the category “graphic design” has made it possible to clarify its definition as a type of design, the purpose of which is to provide visual communication and project visual and meaningful images, and signs through simultaneous artistic, project, technical, design activities and information technologies used for the purpose of visualization and aestheticization of the environment, creation of a high-quality information space at the enterprise, in the community, at the state level, etc. The author’s definition of national font design as a process of creating and reproducing fonts based on cultural traditions and historical features of certain people with the aim of preserving national identity is substantiated.

It has been found that in modern art education, design education, primarily in the training of designers in institutions of higher art education, the problem of updating the content, forms, and methods of using calligraphy and font design on the basis of national traditions, substantiating the methodological principles of reproduction and creation of Ukrainian typefaces is actualized forms, typography, font using samples of national culture. Today, the national preservation principles of font design require a new understanding, the affirmation of traditions, and the study of historical experience, as well as the use of modern digital technologies, which will enable the strengthening of national identity in the field of design education.
SYSTEM OF B. TRYCHKOV CONSCIOUS MUSICAL SINGING AS A MEANS OF DEVELOPING STUDENTS’ MUSICAL ABILITIES
Authors: Medvid T.
Published: August 2023

The article considers the essence of the system of conscious musical singing “Stolbitsa” (“Ladder”) by the Bulgarian teacher B. Trychkov and names his followers: B. Bochev, P. Boyadzhiev, V. Mirchev, K. Stoykov. The role of the didactic method “Ladder” in the development of the musical abilities of students of secondary schools is revealed. The meaning of the term “ladder” in the Bulgarian translation is explained. It is revealed why B. Trichkov calls his method so. It is shown that they contain visual aids called “Ladder” and what are drawing exercises and diagram exercises.

The tasks and forms of work proposed by B. Trichkov in his system according to the age categories of schoolchildren, in particular, first-fourth-grade students, are highlighted. It is indicated what is the most expedient period for “conscious musical singing”. Musical-didactic games are offered, which can be used in this period to stimulate the activity of students during the study of notes. The two main stages of reading the musical text according to the system of B. Trychkov (gradual and abrupt) are analyzed. The order of studying the steps in the process of mastering the scale by the “Ladder” method is indicated.

Five stages of gradual intonation of scale sounds are described; the role of two-part singing in the “Ladder” system is revealed. The reason for B. Trichkov’s criticism of Western European methods “Tonworth” and “Tonic DO” is explained; the significance of the “Bulgarian ladder” and didactic method “Ladder” in the development of musical abilities of students of secondary schools of Ukraine at the present stage is revealed.

The research was facilitated by the content analysis of domestic and foreign methodological literature, scientific sources, and periodicals.
Participatory Evaluation: Factors to Consider When Involving Youth
Authors: Fox Janet , Cater Melissa
Published: August 2023

This article provides a critical perspective on the increasing involvement of young people in participatory evaluation as well as identifies the factors to consider when designing a youth-led evaluation project. Through this avenue, young people will increase their participation in organizational development and community change. Youth-led evaluation can be a powerful tool for supporting youth to move beyond socially determined roles to become active participants in evaluation and their own growth.
Evaluating Fungicide Recommendations for Vegetable Crops in the United States: Should More Be Done to Limit the Risks of Fungicide Resistance Development?
Authors: Wyenandt Andy , Maxwell Nancy
Published: August 2023

Fungicides are an important component of Integrated Pest Management (IPM) programs developed for vegetable production. Without fungicides, commercial vegetable production would not be economically feasible in many regions of the U.S. Recommendations for fungicide use in commercial vegetable production are developed and delivered by Extension in state and regional production guides. Efforts have been made by the chemical industry and Extension to increase the awareness of fungicide resistance development. The article reviews fungicide resistance development and management and current progress and areas of needed improvement in fungicide resistance management guidelines developed for commercial vegetable production in the U.S.
Graduate Students Serve Extension as Evaluation Consultants
Authors: McClure Megan , Fuhrman Nicholas
Published: August 2023

In an effort to provide graduate students at a distance with field-based learning experiences and evaluation resources to statewide Extension programs, 24 Master's students participating in a distance-delivered program evaluation course served as evaluation consultants for Extension programs. State evaluation specialists unable to conduct face-to-face trainings with local Extension agents because of budget constraints should consider mentoring and allowing trained graduate students to assist with local program evaluation efforts. The graduate students benefit from an eager audience and a real-world setting in which to apply their evaluation skills, while their clientele benefit by acquiring individually tailored program-specific evaluation resources.
Evaluation of the efficiency of implementation of asynchronous computing algorithms using coroutines and threads in С++
Authors: Vokhmianin H.Ia. , Zhulkovskyi O.O. , Zhulkovska I.I. , Katan V.A. , Klym V.Iu. , Kuznietsov I.I.
Published: August 2023

Modern multi-core systems are most effective when used in large server centers and for cloud computing. However, despite the known complexity of software implemen-tation, parallel computing on multiprocessors is increasingly used in computer model-ling. Advanced mechanisms of synchronous and multithreaded programming are in-creasingly used to improve the productivity of numerical studies, reducing the time of computer models implementation. One such mechanism is coroutines, a convenient tool for managing asynchronous operations introduced in the C++20 standard. A special feature of coroutines is the ability to suspend a function at a certain stage, saving its state, and after some time resume its execution from the previous stop. The aim of this research is to improve the performance of computer modelling by using coroutines and data threads. As a result of the work, a test algorithm for multiplying a matrix by a vector and its modified asynchronous version using the coroutine mechanism and splitting into two data threads was developed, which allowed to achieve 1.94 times increase in the com-puting speed when the matrix dimension is 15000 (2.25×106 elements). It has been found that at a small matrix dimension, the developed asynchronous algorithm using coroutines and splitting into two threads is less efficient than the single thread algo-rithm. This is due to the fact that the compiler needs some time to create threads and start execution simultaneously. With a large dimensionality, the performance of the asynchronous algorithm increases significantly. With a matrix dimension of more than 1200, the use of an asynchronous algorithm divided into two threads is guaranteed to be more efficient than a single-threaded. The data obtained are consistent with the results of similar studies of the problem of increasing the efficiency of computer modelling using alternative software and hard-ware. The new method of solving the problems of asynchronous programming provides a more efficient and simple mechanism for managing asynchronous operations.
Research in machine learning methods for solving problems of the medical profile
Authors: Ostrovska K.Iu. , Minaienko A.S.
Published: August 2023

The work is devoted to the study of machine learning methods for solving medical problems. The aim of the work is to analyze machine learning methods to improve the accuracy and reduce the time for diagnosing diseases of the genitourinary system in children. The object of research is machine learning methods. The subject of the study is a classifier of diseases of the genitourinary system of patients of the Dnipropetrovsk Re-gional Children's Clinical Hospital "Dnepropetrovsk Regional Council". As a result of the study, the following tasks were solved: an analysis of the literature on the applica-tion of machine learning methods to diseases of the genitourinary system was made; a program was developed to extract the necessary information on statements in a semi-automatic mode; Python libraries and part of machine learning methods were analyzed; primary analysis and processing of data was carried out; applied methods of classifica-tion, feature selection and filling in missing values; the obtained results were analyzed and the substantiation of the research results in the subject area was made.
Komunikasi Fundamental pada Pendidikan Kewirausahaan Bagi Generasi Digital
Authors: Rahayu Sri , Susilawati Tanti , Iskandar Dedy , Nuramat Faqih , Najib Muhamad , Fadhilah Majid Andi
Published: August 2023

Kewirausahaan dan ekonomi kreatif ini merupakan bidang krusial bagi pembangunan berkelanjutan dan berpotensi mendukung perekonomian nasional. Untuk mendukung hal tersebut, pendidikan kewirausahaan mulai tumbuh di hampir semua perguruan tinggi di Indonesia dengan menggunakan berbagai teknik yang dirancang untuk menghasilkan wirausaha. Melalui berbagai program fasilitasi kewirausahaan di perguruan tinggi, pemerintah juga membantu pengembangan budaya kewirausahaan. Pergeseran pola kemahasiswaan yang memunculkan generasi digital merupakan salah satu kesulitan yang dihadapi dalam proses pendidikan kewirausahaan. Taktik komunikasi dalam program pendidikan kewirausahaan di perguruan tinggi perlu diubah agar tetap mengikuti perkembangan zaman dan tren generasi yang berbeda, yang seringkali memiliki sifat dan preferensi belajar yang berbeda. Penelitian dilakukan dengan menggunakan metode deskriptif dengan studi kepustakaan, wawancara, dan observasi terhadap prosedur pendidikan kewirausahaan Universitas. Dengan mengkaji unsur-unsur komunikasi yang meliputi komunikator, pesan, saluran (media), penerima, dan efek, makalah ini memberikan penjelasan tentang praktik dan metode komunikasi pendidikan kewirausahaan bagi generasi digital. Temuan menunjukkan bahwa metode komunikasi dimaksudkan untuk menghasilkan dampak yang kreatif, kognitif, kolaboratif, kompeten, dan kompak. Menggunakan komunikator pesan bisnis yang menarik dan andal adalah aspek lain dari pendekatan yang diselidiki dan didukung. dengan memaksimalkan penggunaan teknologi digital, menyampaikan pesan informasi, persuasi, dan pendidikan, dan mempraktikkan ide-ide media.
Effect of CR, DER, and TATO on Profit Growth in Pharmaceutical Companies Listed on IDX
Authors: Panjaitan Harry Patuan , Alfinas Daud
Published: August 2023

This study aims to determine the influence of Current Ratio, Debt to Equity Ratio, and Total Assets Turnover on Profit Growth in pharmaceutical sub-sector manufacturing companies which were listed on Indonesia Stock Exchange in 2014-2018. The sample consisted of 9 pharmaceutical companies which were obtained using purposive sampling method. This study used multiple linear regression analysis and SmartPLS 3. The results showed that Current Ratio and Debt to Equity Ratio do not have significant influence on Profit Growth. Meanwhile, Total Assets Turnover has a significantly negative influence on Profit Growth.
Troubleshooting Generator Sets using Expert System
Authors: Nopendri Nopendri , Nasien Dewi
Published: August 2023

PT. Zaman Teknindo (PT. ZT) is a company engaged in Mechanical and Engineering field which is registered as one PT. Telkomsel vendors. The problems that occur at PT. ZT, if the power outage and generator set (generator) does not start automatically. The corrective team on duty at that time will go to the field and find a solution to the problem. With a lack of knowledge from the corrective team, they need help from the mechanical team. The mechanical team is an external team of PT. ZT. To bring a mechanical team requires an enormous cost and a relatively long time needed to get to the location. Based on the problem above, this study proposes a forward chaining expert system that is by depth-first search using the certainty factor method. To prove whether a fact is certain or not, it must be in the metric form in generator troubleshooting. The research methodology used the Software Development Life Cycle (SDLC) starting from problem identification, analysis, design, coding, testing and maintenance. This system is web-based, so users can easily access and choose symptoms of the damage. With this system makes it easy for PT. ZT especially the corrective team in the field can easily find out the damage symptoms without having to meet with experts directly.