bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymptotic behavior of Newton-like inertial dynamics involving the sum of potential and nonpotential terms
Authors: Adly Samir , Attouch Hedy , Vo Van Nam
Published: October 2021

In a Hilbert space $\mathcal{H}$
H
, we study a dynamic inertial Newton method which aims to solve additively structured monotone equations involving the sum of potential and nonpotential terms. Precisely, we are looking for the zeros of an operator $A= \nabla f +B $
A
=
∇
f
+
B
, where ∇f is the gradient of a continuously differentiable convex function f and B is a nonpotential monotone and cocoercive operator. Besides a viscous friction term, the dynamic involves geometric damping terms which are controlled respectively by the Hessian of the potential f and by a Newton-type correction term attached to B. Based on a fixed point argument, we show the well-posedness of the Cauchy problem. Then we show the weak convergence as $t\to +\infty $
t
→
+
∞
of the generated trajectories towards the zeros of $\nabla f +B$
∇
f
+
B
. The convergence analysis is based on the appropriate setting of the viscous and geometric damping parameters. The introduction of these geometric dampings makes it possible to control and attenuate the known oscillations for the viscous damping of inertial methods. Rewriting the second-order evolution equation as a first-order dynamical system enables us to extend the convergence analysis to nonsmooth convex potentials. These results open the door to the design of new first-order accelerated algorithms in optimization taking into account the specific properties of potential and nonpotential terms. The proofs and techniques are original and differ from the classical ones due to the presence of the nonpotential term.
Ultrasound-accelerated thrombolysis in high-risk perioperative pulmonary embolism: two case reports and review of literature
Authors: Schmidt Götz , Edinger Fabian , Koch Christian , Wolff Matthias , Biehl Christoph , Hörbelt Rüdiger , Sander Michael
Published: October 2021

Introduction

Treatment of high-risk pulmonary embolism (PE) in perioperative patients remains challenging. Systemic thrombolysis is associated with a high risk of major bleedings and intracranial haemorrhage. High mortality rates are reported for open pulmonary embolectomy. Therefore, postoperative surgical patients may benefit substantially from catheter-directed ultrasound-accelerated thrombolysis (USAT).

Case presentation

We report two cases of high-risk perioperative PE. Both patients developed severe haemodynamic instability leading to cardiac arrest. After the implantation of a veno-arterial extracorporeal membrane oxygenation (ECMO), they were both successfully treated with USAT. Adequate improvement of right ventricular function was achieved; thus, ECMO could be successfully weaned after 3 and 4 days, respectively. Both patients showed favourable outcomes and could be discharged to rehabilitation.

Conclusion

Current guidelines on treatment of PE offer no specific therapies for perioperative patients with high-risk PE. However, systemic thrombolysis is often excluded due to the perioperative setting and the risk of major bleeding. Catheter-directed thrombolysis was shown to utilise less thrombolytic agent while obtaining comparable thrombolytic effects. The risk for major bleeding (including intracranial haemorrhage) is also significantly lowered. Until further trials determining the value of adopted treatment strategies of high-risk PE in perioperative patients are available, USAT should be considered in similar cases.
Phenotypic intrafamilial variability including H syndrome and Rosai–Dorfman disease associated with the same c.1088G > A mutation in the SLC29A3 gene
Authors: Chouk Hamza , Ben Rejeb Mohamed , Boussofara Lobna , Elmabrouk Haїfa , Ghariani Najet , Sriha Badreddine , Saad Ali , H’Mida Dorra , Denguezli Mohamed
Published: October 2021

Background

Mutations in the SLC29A3 gene, which encodes the nucleoside transporter hENT3, have been implicated in syndromic forms of histiocytosis including H syndrome, pigmented hypertrichosis with insulin-dependent diabetes, Faisalabad histiocytosis and Familial Rosai–Dorfman disease (RDD). Herein, we report five new patients from a single family who present with phenotypes that associate features of H syndrome and Familial Rosai–Dorfman disease.

Methods

We investigated the clinical, biochemical, histopathological and molecular findings in five Tunisian family members' diagnosed with Familial RDD and/or H syndrome. The solute carrier family 29 (nucleoside transporters), member 3 (SLC29A3) gene was screened for molecular diagnosis using direct Sanger sequencing.

Results

Genetic analysis of all affected individuals revealed a previously reported missense mutation c.1088 G > A [p.Arg363Gln] in exon 6 of the SLC29A3 gene. Four affected members presented with clinical features consistent with the classical H syndrome phenotype. While their cousin’s features were in keeping with Familial Rosai–Dorfman disease diagnosis with a previously undescribed cutaneous RDD presenting as erythematous nodular plaques on the face. This report underlines the clinical variability of SLC29A3 disorders even with an identical mutation in the same family.

Conclusion

We report a rare event of 5 Tunisian family members' found to be homozygous for SLC29A3 gene mutations but showing a different phenotype severity. Our study reveals that despite a single mutation, the clinical expression of the SLC29A3 disorders may be significantly heterogeneous suggesting a poor genotype–phenotype correlation for the disease.
Expression of circulating cell-free nucleic acids around miniscrew implant during orthodontic tooth movement—a prospective study
Authors: Qureshi Tabassum , Duggal Ritu , Kharbanda Om Prakash , Rajeswari Moganty R.
Published: October 2021

Objectives

Literature shows that the expression of various biomarkers in peri-miniscrew crevicular fluid (PMICF) is related to the stability of miniscrew implants (MSIs). The present study investigated the role and alterations in levels of circulating cell-free nucleic acids (cfNAs) in PMICF before and after orthodontic loading.

Material and methods

This prospective study consisted of forty-six MSIs placed between the second premolar and first molar in the maxillary and mandibular arches. Direct loading was done after 3 weeks of MSI insertion with nickel-titanium closed coil spring exerting a force of 200 g. The PMICF sample was collected at various time intervals, and the level of cfNA was determined. Clinical parameters, including implant mobility and gingival health, were also assessed. Pre-loading and post-loading parameters were assessed using Wilcoxon’s rank-sum test.

Results

Among 46 MSIs, 36 were stable during the study and 10 MSIs showed peri-implant inflammation and increased mobility. There was a significant rise in the cfNA concentration 24 h after implant insertion (0.4 ± 0.86 ng/μl). The level of cfNAs significantly decreased over 3 weeks and reached the baseline level (0.2 ± 0.31 ng/μl). There was also a significant rise in the levels of cfNA (0.8 ± 0.70 ng/μl) at 24 h after loading MSIs, which gradually decreased to 0.2 ± 0.24 ng/μl after 63 days. The expression of cfNAs was on the average 0.32 units more in the cases with failed implants (P = 0.05).

Conclusions

cfNA levels in PMICF showed an upward trend 24 h after MSI insertion and 24 h after orthodontic loading. The expression of cfNA was more in cases with failed MSIs. Hence, the cfNAs can be considered as a prognostic biomarker of MSI stability.
Comparison of zirconia degradation in dental implants and femoral balls: an X-ray diffraction and nanoindentation study
Authors: Gil Javier , Delgado-García-Menocal José Angel , Velasco-Ortega Eugenio , Bosch Begoña , Delgado Luis , Pérez-Antoñanzas Román , Fernández-Fairén Mariano
Published: October 2021

Background

New tetragonal zirconia polycrystal dental implants stabilized with yttria (Y-TZP) have appeared in the implantology market in the form of single piece or two-piece zircona implant system. These new type of implants improve the aesthetical properties compared to conventional commercially pure (c.p.) titanium used for implants, although the long term mechanical behavior of these new implants is not yet well known. In orthopaedics, the application of zirconia as femoral balls presented an important controversial use due to the premature fracture once implanted. Y-TZP dental implants can be affected by hydrothermal degradation and its behavior should be analysed to avoid a premature fracture. The scientific question behind the study is to analyse if the degradation mechanism observed in orthopaedics applications of Y-TZP is similar to that of Y-TZP for dental applications.

Materials and methods

For this purpose, 30 original Y-TZP dental implants and 42 Y-TZP femoral balls fractured in vivo have been studied. Dental implants were submitted to an accelerated hydrothermal degradation to compare with the femoral balls fractured in vivo. Phase transformation as well as the mechanical behaviour of the degraded samples was studied by X ray diffraction and nanoindentation tests, respectively.

Results

Results have shown that the fracture mechanism of dental implants does not resemble the mechanism observed in orthopaedic samples, presenting a good long-term behaviour.

Conclusion

The results ensure the good performance of zirconia dental implants, because the degradation of the ceramic is very limited and does not affect the mechanical properties.
Noise suppression using a near-source wavelet
Authors: Aghayan Afshin , Jaiswal Priyank
Published: October 2021

Denoising becomes a nontrivial task when the noise and signal overlap in multiple domains, such as time, frequency, and velocity. Fortunately, signal and noise waveforms, in general, tend to remain morphologically different and such differences can be used to separate body-wave signals from other waveforms such as ground roll and cultural noise. The key in denoising using a near-source wavelet is to find a wavelet that is a close approximation of the true source signature and remains uncontaminated by the Green’s function in any significant manner. An inverse filter designed using such a wavelet selectively compresses the body waves that can be extracted using median and low-pass filters. The overall phenomenon is explained with a synthetic example. The idea is also tested on a land data set generated using a large weight-drop source in which the wavelet recorded approximately 3 m from the source location fulfills the criteria set in our method. The results suggest that the incremental effort of recording an extra trace close to the source location during acquisition may provide previously unavailable denoising opportunities during processing, although the trace itself may be redundant for imaging.
Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia
Authors: Linglart Agnès , Imel Erik A , Whyte Michael P , Portale Anthony A , Högler Wolfgang , Boot Annemieke M , Padidela Raja , van’t Hoff William , Gottesman Gary S , Chen Angel , Skrinar Alison , Scott Roberts Mary , Carpenter Thomas O
Published: October 2021

Purpose

In X-linked hypophosphatemia (XLH), excess fibroblast growth factor-23 causes hypophosphatemia and low calcitriol, leading to musculoskeletal disease with clinical consequences. XLH treatment options include conventional oral phosphate with active vitamin D, or monotherapy with burosumab, a monoclonal antibody approved to treat children and adults with XLH. We have previously reported outcomes up to 64 weeks, and here we report safety and efficacy follow-up results up to 160 weeks from an open-label, multicenter, randomized, dose-finding trial of burosumab for 5- to 12-year-old children with XLH.

Methods

After 1 week of conventional therapy washout, patients were randomized 1:1 to burosumab every 2 weeks (Q2W) or every 4 weeks (Q4W) for 64 weeks, with dosing titrated based on fasting serum phosphorus levels between baseline and week 16. From week 66 to week 160, all patients received Q2W burosumab.

Results

Twenty-six children were randomized initially into each Q2W and Q4W group and all completed treatment to week 160. In 41 children with open distal femoral and proximal tibial growth plates (from both treatment groups), total Rickets Severity Score significantly decreased by 0.9 ± 0.1 (least squares mean ± SE; P < 0.0001) from baseline to week 160. Fasting serum phosphorus increases were sustained by burosumab therapy throughout the study, with an overall population mean (SD) of 3.35 (0.39) mg/dL, within the pediatric normal range (3.2-6.1 mg/dL) at week 160 (mean change from baseline P < 0.0001). Most adverse events were mild to moderate in severity.

Main conclusions

In children with XLH, burosumab administration for 160 weeks improved phosphate homeostasis and rickets and was well-tolerated. Long-term safety was consistent with the reported safety profile of burosumab.

Clinicaltrials.gov

NCT02163577
Fetal and Neonatal Thyroid Dysfunction
Authors: Léger Juliane , Delcour Clemence , Carel Jean-Claude
Published: October 2021

Fetal and neonatal dysfunctions include rare serious disorders involving abnormal thyroid function during the second half of gestation, which may persist throughout life, as for most congenital thyroid disorders, or be transient, resolving in the first few weeks of life, as in autoimmune hyperthyroidism or hypothyroidism and some cases of congenital hypothyroidism (CH) with the thyroid gland in situ. Primary CH is diagnosed by neonatal screening, which has been implemented for 40 years in developed countries and should be introduced worldwide, as early treatment prevents irreversible neurodevelopmental delay. Central CH is a rarer entity occurring mostly in association with multiple pituitary hormone deficiencies. Other rare disorders impair the action of thyroid hormones. Neonatal Graves’ disease (GD) results from the passage of thyrotropin receptor antibodies (TRAbs) across the placenta, from mother to fetus. It may affect the fetuses and neonates of mothers with a history of current or past GD, but hyperthyroidism develops only in those with high levels of stimulatory TRAb activity. The presence of antibodies predominantly blocking thyroid-stimulating hormone receptors may result in transient hypothyroidism, possibly followed by neonatal hyperthyroidism, depending on the balance between the antibodies present. Antithyroid drugs taken by the mother cross the placenta, treating potential fetal hyperthyroidism, but they may also cause transient fetal and neonatal hypothyroidism. Early diagnosis and treatment are key to optimizing the child’s prognosis. This review focuses on the diagnosis and management of these patients during the fetal and neonatal periods. It includes the description of a case of fetal and neonatal autoimmune hyperthyroidism.
The Life Strike
Authors: Bentouhami Hourya
Published: October 2021

This article examines the forms of disobedience practiced by migrants at the European border to circumvent biotechnological modes of surveillance and identification, which are rooted in involuntary movements that can be used as evidence against migrants. What actually happens when bodily growth, heart rate, respiration, and body heat are integrated into technologies for the detection of life with a view to their measurement (biometrics) and the constitution of a database needed for border surveillance? What happens when life is turned against itself? How to disobey when the involuntary dimensions of the body—not only one's appearance but the body's very organicity and biochemistry—become the sites of a surveillance from which one can only escape by holding one's breath or burning one's fingerprints? This essay asks how the emerging tactics of migrants seek to escape their interior, organic lives, and identifies the “life strike” as a form of thanato-mimesis that consists in playing dead and limiting what in organic life is recognizable as such in order to go unnoticed and to interrupt racial interpellations.
Abolition Pedagogy
Authors: Gillespie Kelly , Naidoo Leigh-Ann
Published: October 2021

As the South African student movement of 2015–16 began to develop a deeper critique of the character of the transition out of apartheid and its minimal effect on the institutions of colonialism and apartheid, the administrators of postapartheid universities worked with the managers of the security infrastructure of the state to orchestrate a national police shutdown of the student and worker movement. This essay is an effort to sustain an objection to that coordinated effort, and to work through a proposal for how the new managers of the postapartheid state and university could have—should have—acted otherwise. This proposal is called abolition pedagogy, a refusal of the long-standing relationship between education and violence, and a reading of the pedagogic labor involved in antiviolence work. In the midst of the recent student protests, a 1969 exchange of letters between Theodor Adorno and Herbert Marcuse—in which Adorno justifies his having “called the police” on the student movement in Germany—was used to justify calling the police on South African students some fifty years later. This article unpacks the citation, and uses Adorno's own commitment to critique as a “force field” to show up the limitations of his position, and to call for a different mode of engagement with the difficulties and possibilities of ongoing struggle. Adorno's “force field” is contrasted with his poor reckoning with jazz and his inability to see the work of critique in jazz and by implication in many other forms. Abolition pedagogy pursues a transformative orientation to histories of violence, asking how to sustain strategies for their unmaking.
Acute Neuromuscular Response to Team Sports–Specific Running, Resistance, and Concurrent Training: A Crossover Study
Authors: CROSS REBECCA , LOVELL RIC , MARSHALL PAUL W. , SIEGLER JASON
Published: October 2021

Purpose

This study aimed to examine the changes in muscle contractile function, voluntary activation, and muscle damage after lower limb resistance training (RT), intermittent sprint exercise, and concurrent training (CT).

Methods

Ten male, recreational team sport athletes with a history of RT participated in a randomized crossover study involving an intermittent sprint protocol (ISP), lower limb RT, and CT (ISP and RT separated by 1 h). Before (PRE), immediately after (POST), 24 h and 48 h after each exercise condition, quadriceps muscle activation, voluntary activation, muscle contractile function (evoked twitch responses), creatine kinase, muscle soreness, and Profile of Mood States (POMS)–fatigue were recorded.

Results

Quadriceps contractile function was hampered in all conditions, with a significantly greater decline observed POST RT (58.4% ± 18.0%) and CT (54.8% ± 8.6%) compared with ISP (35.9% ± 10.7%, P < 0.05), recovering at 48 h after all exercise conditions. POMS–fatigue ratings increased at POST in all conditions with CT and ISP eliciting the greatest increase, returning to baseline 48 h after all exercise conditions. Quadriceps muscle soreness remained elevated from PRE at 48 h after all exercise conditions. No changes across time were observed for voluntary activation and quadriceps surface EMG amplitude after any exercise condition. The volume and load lifted in the RT session was unaffected by previous intermittent exercise (ISP) in CT.

Conclusions

RT impairs contractile function, which is not exacerbated when performed 1 h after the ISP. Contractile function after all exercise conditions displayed the same recovery profile (48 h) despite the postexercise decrement being smaller after the ISP compared with RT and CT. Previous intermittent sprint exercise does not negatively affect the volume of exercise performed in a lower limb RT session.
Effects of Water Immersion on the Internal Power of Cycling
Authors: VINETTI GIOVANNI , FERRETTI GUIDO , HOSTLER DAVID
Published: October 2021

Purpose

Water immersion adds additional drag and metabolic demand for limb movement with respect to air, but its effect on the internal metabolic power (Ė
int) of cycling is unknown. We aimed at quantifying the increase in Ė
int during underwater cycling with respect to dry conditions at different pedaling rates.

Methods

Twelve healthy subjects (four women) pedaled on a waterproof cycle ergometer in an experimental pool that was either empty (DRY) or filled with tap water at 30.8°C ± 0.6°C (WET). Four different pedal cadences (f
p) were studied (40, 50, 60, and 70 rpm) at 25, 50, 75, and 100 W. The metabolic power at steady state was measured via open circuit respirometry, and Ė
int was calculated as the metabolic power extrapolated for 0 W.

Results

The Ė
int was significantly higher in WET than in DRY at 50, 60, and 70 rpm (81 ± 31 vs 32 ± 30 W, 167 ± 35 vs 50 ± 29 W, 311 ± 51 vs 81 ± 30 W, respectively, all P < 0.0001), but not at 40 rpm (16 ± 5 vs 11 ± 17 W, P > 0.99). Ė
int increased with the third power of f
p both in WET and DRY (R
2 = 0.49 and 0.91, respectively).

Conclusions

Water drag increased Ė
int, although limbs unloading via the Archimedes’ principle and limbs shape could be potential confounding factors. A simple formula was developed to predict the increase in mechanical power in dry conditions needed to match the rate of energy expenditure during underwater cycling: 44 f
p
3 – 7 W, where f
p is expressed in Hertz.
Los años iniciales de la intervención bélica holandesa en Brasil, 1621-1635
Authors: Garrido Díez De Baldeón Enrique
Published: October 2021

El trabajo presentado en estas líneas supone un recorrido histórico por los primeros años de actividad militar holandesa en Brasil durante el siglo XVII. Un estudio en el que se analizan las razones que llevaron a los Países Bajos a emprender acciones contra la colonia luso-española, el papel protagonista de la Compañía de las Indias Occidentales –WIC–, las intervenciones militares y de conquista desarrolladas por los holandeses en el nordeste brasileño y las iniciativas de contraofensiva ibérica. Todo ello prestando especial atención a las diversas fases que atravesó la guerra y a la ineficacia de numerosas tácticas y estrategias militares europeas sobre suelo americano.
Desperdícios na manutenção ferroviária
Authors: Dias Emanoel Roza , Serra Mayanne Camara , Lima Elon Vieira
Published: October 2021

A filosofia de gestão Lean Manufacturing pode ser aplicada para elevar a eficiência de manutenções ferroviárias, principalmente com a identificação de desperdícios, já que os custos neste modal são expressivos. Este estudo almeja analisar os desperdícios presentes nos processos de manutenção de Via Permanente no Terminal Ferroviário de Ponta da Madeira. Para tanto, foi desenvolvida uma pesquisa-ação no setor de Via Permanente do terminal ferroviário, onde opera uma multinacional no escoamento de minério de ferro e outros produtos. A condução do estudo na identificação de desperdícios ocorreu de acordo com abordagem da Filosofia Lean e com aplicação de ferramentas da qualidade. Ao analisar o desperdício por esperas para liberação das faixas de trabalho do setor de Via Permanente, propôs-se a implementação da sistemática de priorização para tratar os problemas identificados. Ademais, foram elaboradas propostas de solução e ou controle, dentre as quais destaca-se a definição de indicadores quanto aos tempos de espera das equipes de manutenção.
Gestão da cadeia de suprimentos no setor público brasileiro
Authors: Santos Elaine Michele Diniz , Santos Manoela Silveira dos , Kapp Marcelo Nepomoceno , Oliveira Gilson Batista de
Published: October 2021

O objetivo deste artigo é, por meio da revisão sistemática de literatura, levantar e organizar as informações a respeito das publicações que tratam da cadeia de suprimentos do setor público brasileiro. A necessidade de inovação para manter as atividades do Setor Público com foco no cidadão garantindo a qualidade e a eficiência do gasto público, levando em consideração que o orçamento das Instituições Públicas de Ensino Superior no Brasil não é suficiente para abarcar o desenvolvimento de todos os campos de pesquisa que seus pesquisadores podem atuar, se torna imprescindível a busca por formas de gestão que contribuam para a melhoria da eficiência e eficácia do serviço público, nesse sentido, a Gestão de Cadeias de Suprimento pode contribuir para o alcance deste fim. Assim, este artigo pesquisa a Gestão de Cadeias de Suprimento no Setor Público dentre os principais eventos e periódicos do campo de pesquisa proposto, compilando os dados e revelando o estado da arte desta temática, sintetizando para qual direção os estudos apontam além de contribuir com novos insights sobre o assunto visando prover o melhor nível de evidências para tomadas de decisão. Esta pesquisa demonstrou a baixa incidência de estudos nesta área, que justifica-se pelo fato da GCS ser mais utilizada no segundo setor, uma vez que, suas aplicações ao setor público necessitam de pesquisas e adaptações para alcançar as especificidades da Administração Pública.
Impacto técnico-econômico da alteração do processo de fabricação de machos
Authors: Cabral Jaqueline Pereira , Rodrigues Gabrielly do Carmo , Lima Carlos Roberto Camello
Published: October 2021

A fundição de peças com cavidades requer moldes e machos. Para a fabricação dos machos, diversos processos podem ser aplicados. Este trabalho objetiva estudar a viabilidade da mudança do processo da fabricação de machos de Hot Box para Shell Molding. É realizado um estudo de caso em uma fundição de latão, buscando maior produtividade e menor perda na produção. Foram realizados levantamentos das perdas na fundição, coletados dados de tempo de ciclo, rendimento e refugo dos machos por etapa do processo. Com esses dados, foi calculado o tempo produtivo perdido em refugo para cada método. Como resultado, foi determinado que a alteração aumentaria a produtividade total da fundição em 5,9 %. Também foi calculada a viabilidade econômica do projeto, levando-se em consideração custos de equipamento, adaptações e treinamentos. Foi concluído que o payback desse projeto se daria em trinta e nove meses.
Análise, investigação e avaliação da gestão da qualidade no processo de mineração
Authors: Fernandes Rafael da Silva , Sousa Lucas Rafael Castro de , Santos Thaynara Lopes dos
Published: October 2021

É de grande relevância a cautela com as informações de estoques, num processo de produção do minério de ferro, para que os saldos apontados em sistemas informatizados apresentem acurácia com os saldos físicos armazenados. Tem-se assim, que a acurácia determina a capacidade da empresa em fornecer informações confiáveis aos stakeholders ao permitir a identificação de divergências, sendo que a sua falta, pode acarretar em efeitos indesejáveis nos diversos processos organizacionais. Neste âmbito, o objetivo deste trabalho é duplo: num primeiro momento, visa responder a seguinte pergunta: Como minimizar os desvios entre estoque físico e contábil, do produto Pellet feed Especial, nas etapas de produção e expedição de um mineradora localizada no sudeste do estado do Pará, por meio da aplicação da metodologia PDCA e ferramentas para a melhoria da qualidade? E, num segundo momento, visa fornecer à empresa, em particular ao setor envolvido, ferramentas da qualidade para que, estas, sejam aplicadas continuamente como melhoria do processo estudado. No entanto, após observar uma melhora inicial da Qualidade, posteriormente o processo apresentou medidas fora dos limites de especificação. Por fim, uma nova análise e investigação quantitativa de variáveis ainda não consideradas foi realizada, propondo a continuação do estudo para alcançar resultados mais satisfatórios, em particular, quanto a redução das divergências no processo produtivo abordado.
Estímulos e barreiras para a economia circular no setor alimentício
Authors: Almeida Gabriel de Ávila de , Aguiar Marina Fernandes , Jugend Daniel
Published: October 2021

O objetivo deste artigo é identificar artigos acadêmicos que tratam da transição para a economia circular (EC) no setor alimentício e analisar os principais estímulos, barreiras e práticas envolvidas neste processo. Para isso, uma revisão sistemática de literatura foi conduzida, utilizando a base Scopus. A partir da análise bibliométrica, de rede de palavras-chave e de conteúdo, foi possível obter uma visão geral das discussões atuais sobre o tema, que apresenta um crescente interesse, com protagonismo de países europeus e do Brasil. Entre os principais estímulos, foram identificados a eficiência energética, as novas oportunidades de mercado, a colaboração com stakeholders, a ecoeficiência e as possíveis reduções de custos. Dentre as barreiras, foram cinco as principais: tecnológicas, financeiras, operacionais, aceitação dos consumidores e legislação. A redução do consumo de matéria prima e o uso de subprodutos foram as práticas mais abordadas pelos artigos, indicando que o setor alimentício ainda tem potencial para implementar outras estratégias em direção à EC, como resultado da manufatura eficiente e uso mais inteligente dos produtos.
Melhoria dos processos extrativistas na apicultura a luz da engenharia da qualidade
Authors: Souza Marina Lunga Dias , Mendonça Francisca Jeanne Sidrim de Figueiredo , Souza Bruna Stephany Coelho de , Feitosa Amanda Duarte , Duarte Ana Karine Gomes
Published: October 2021

A apicultura é uma atividade extrativista sustentável, que resulta em uma gama de produtos, sendo o mel o que possui maior valor, sua rentabilidade é responsável pela subsistência de inúmeras famílias. O Brasil está entre os quinze maiores produtores de mel do mundo, devido a sua alta exploração e comercialização, tornando-se causa de disputa entre consumidores por seu baixo percentual de contaminação. No entanto, a sua produção artesanal e adequações produtivas têm sido gargalo na produção inócua. O presente trabalho busca identificar os principais contaminadores dentro do ambiente extrativo, com o propósito de diminuí-los ou levá-los à extinção. Foram utilizadas ferramentas da qualidade como Diagrama Causa e Efeito e o Gráfico de Pareto, aliadas as boas práticas de fabricação e o Sistema de Análise de Perigos e Pontos Críticos de Controle (APPCC), objetivando elencar estrategicamente os meios contaminadores e propor um plano de ação mútuo aos produtores bem como recomendação de mudanças nos arranjos físicos, aumentando a qualidade do mel da região e, por consequência, elevar seu valor comercial.
Contribuições do kanban eletrônico e tradicional para a gerenciamento de leitos hospitalares
Authors: Silva Thainy Genny Esteves , Silva Mariane Francis Souza Bezerra da , Vieira Lara Camila Nery , Pimentel Cristiane Angra , Musetti Marcel Andreotti
Published: October 2021

A falta de leitos resulta em filas de espera e em pacientes em corredores esperando em macas aguardando por leitos. Estes desafios geram a insatisfação nos pacientes e nos profissionais da saúde e podendo causar o aumento de gasto da organização, por conta do tempo elevado de permanência em internações e má gerenciamento dos recursos. O uso do gerenciamento de leito e de conceitos e ferramentas da filosofia Lean Healthcare, como o Kanban que permite melhor controle das demandas e auxilia no aumento da taxa de ocupação das instituições, maior utilização da capacidade disponível, tendo efeito direto no aumento da satisfação dos pacientes. Este artigo pretende apresentar as diferentes características do Kanban tradicional e eletrônico para a gerenciamento de leitos. A metodologia empregada foi a pesquisa exploratória e bibliográfica. Foram utilizados mecanismos de busca como Google Scholar, Web of Science e Scopus, conforme as palavras-chave:  lean healthcare, kanban, kanban eletrônico, gerenciamento de leitos, entre outros termos relacionados para uma ampla busca sobre o conteúdo. Com a análise realizada os resultados encontrados foram as contribuições geradas da utilização da ferramenta Kanban eletrônico, que proporciona uma otimização no gerenciamento de leitos através da eficiência no acesso e atualização de dados, aumentando a autonomia dos agentes de saúde e oferecendo atendimentos com qualidade para os pacientes. O estudo contribui para a sociedade acadêmica fornecendo um panorama da utilização da ferramenta Kanban em unidades hospitalares para o gerenciamento de leitos.
Dimensionamento e viabilidade econômica de um sistema fotovoltaico
Authors: Silva Beatriz Lorrane Farias , Santos Neto Iamara dos , Fernandes Rafael da Silva , Branco Najmat Celene , Guimarães Gabriella Vitorino
Published: October 2021

A adoção do uso de fontes de energia renováveis é um tema comumente debatido, visto os problemas ambientais vivenciados pela sociedade em todo o mundo. No entanto, apesar do potencial brasileiro de geração de energia solar, a sua participação na matriz energética nacional ainda é incipiente, correspondendo a apenas 1% do total. Além disso, a maioria do seu uso se concentra em edificações residenciais e comerciais, havendo pouco incentivo para a implementação em prédios públicos. Neste contexto, o objetivo deste artigo é, através de uma metodologia estruturada de dimensionamento de um sistema fotovoltaico (SFV), analisar a demanda contratada vigente e verificar a viabilidade econômica de implementação desse sistema na Universidade Federal Rural da Amazônia – Campus Parauapebas, localizada no sudeste do Pará. Os resultados indicam que a potência de geração fotovoltaica total necessária para atender o Campus é de 240 kW; no entanto, a demanda contratada é de apenas 130 kW. Desta forma, o cálculo de viabilidade econômica da implementação de um SFV com uma demanda inferior indica que, apesar do elevado investimento inicial e dado uma economia mensal média de R$ 9.674,04, obteve-se um VPL satisfatório, payback de 44 meses e uma TMA de 1,6074% a.m.
Molecular mechanisms of vasculopathy and coagulopathy in COVID-19
Authors: Al-Gburi Suzan , Beissert Stefan , Günther Claudia
Published: October 2021

COVID-19 primarily affects the respiratory system and may lead to severe systemic complications, such as acute respiratory distress syndrome (ARDS), multiple organ failure, cytokine storm, and thromboembolic events. Depending on the immune status of the affected individual early disease control can be reached by a robust type-I-interferon (type-I-IFN) response restricting viral replication. If type-I-IFN upregulation is impaired, patients develop severe COVID-19 that involves profound alveolitis, endothelitis, complement activation, recruitment of immune cells, as well as immunothrombosis. In patients with proper initial disease control there can be a second flare of type-I-IFN release leading to post-COVID manifestation such as chilblain-like lesions that are characterized by thrombosis of small vessels in addition to an inflammatory infiltrate resembling lupus erythematosus (LE). Mechanistically, SARS-CoV-2 invades pneumocytes and endothelial cells by acting on angiotensin-II-converting enzyme 2 (ACE2). It is hypothesized, that viral uptake might downregulate ACE2 bioavailability and enhance angiotensin-II-derived pro-inflammatory and pro-thrombotic state. Since ACE2 is encoded on the X chromosome these conditions might also be influenced by gender-specific regulation. Taken together, SARS-CoV-2 infection affects the vascular compartment leading to variable thrombogenic or inflammatory response depending on the individual immune response status.
Protein Distribution: Recommendations and Practical Applications for Elite Athletes and Active Adults
Authors: Moore Paul , Krause Alexandra
Published: October 2021

Evenly distributing protein throughout the day is being examined in current research to determine its affect on athletic performance and muscle protein synthesis. Research has suggested that protein amount and timing need to be taken into account to optimize the anabolic window and encourage muscle repair postworkout. This article provides a discussion of muscle protein synthesis, the protein threshold, increasing hypertrophy, the positive performance impact of evenly distributing protein throughout the day, and offers practical applications for these research-based recommendations. This article will help dietitians, strength and conditioning coaches, and others working with elite athletes and/or active adults to make recommendations that are evidence based and related to current research on protein timing and suggested amounts of protein throughout the day.
Performance Profiling in Strength and Conditioning
Authors: Johnson David L. , Bird Matthew D.
Published: October 2021

Performance profiling is a client-led assessment tool that enables athletes to uncover strengths and weaknesses associated with their sporting performance. Initially designed to increase client commitment to a training program, the performance profiling technique presents an opportunity for the athlete to play an active role and contribute to the initial needs analysis process. This evidenced-based method of assessment has been shown to help clients increase their self-awareness, identify areas they can improve, and serve as a basis for goal setting. The tool also permits both client and practitioner to monitor and track progress over time. Although predominantly adopted for those providing psychological support to athletes, the performance profile may be beneficial for strength and conditioning coaches. This article aims to highlight the potential benefits of performance profiling within the field of strength and conditioning, provides guidelines with completed examples for strength and conditioning practitioners to integrate into their work with clients, and presents a brief overview of the theory underpinning the technique.
TSH concentrations in parents and their offspring: a cross-sectional family-based analysis
Authors: Girschik Carolin , Drogge Sophie-Charlotte , Kowall Bernd , Lehmann Nils , Stang Andreas , Zwanziger Denise , Erbel Raimund , Führer Dagmar , Jöckel Karl-Heinz
Published: October 2021

Objective

Studies that evaluated the genetic influences on thyroid-stimulating hormone (TSH) concentrations were primarily performed in twin cohorts. The aim of this study was to investigate the sex-specific association of serum TSH concentrations between parents and their offspring.

Methods

We used data from the population-based Heinz Nixdorf Recall Study and the associated MultiGeneration Study, including offspring and their biological parents. In 3115 participants (including 1558 offspring from 1138 families), self-reported thyroid diseases and median TSH concentrations depending on thyroid status were assessed. Familial associations of TSH concentrations were investigated in 1485 healthy subjects using linear regression modeling in each group of the parent–offspring relationship using the parent’s TSH concentration as the exposure of interest. To account for the family effect, a mixed‐effects ordinal logistic regression model with random intercept varying at the family level was fitted, using the TSH concentration of the offspring classified into sex- and age-specific quartiles as the outcome.

Results

For every 1 mIU/L increase in the mother’s or father’s TSH concentration, the daughter’s TSH concentration increases by 0.13 mIU/L (95% CI: −0.01; 0.27) and 0.19 mIU/L (0.05; 0.33), respectively, and the son’s TSH concentration increases by 0.13 mIU/L (0.02; 0.25) and 0.20 mIU/L (0.08; 0.32), respectively. Further sensitivity analyses by expanding inclusion criteria and taking family clustering into account corroborated these results.

Conclusions

Serum TSH concentrations of parents are positively associated with those of their offspring in all sex-specific relationships.
Algebras of entire functions containing functions of unbounded type on a Banach space
Authors: Zagorodnyuk A. , Hihliuk A.
Published: October 2021

In this paper, we consider algebras of entire analytic functions which are bounded on a prescribed family of balls in a Banach space. We investigate the structures of such algebras and describe their spectra in terms of spectra of algebras of uniformly continuous analytic functions. Some partial examples are considered. In particular, we have complete descriptions of the spectra for the case of Tsirelson space and for $c_0$.
Completely positive maps for imprimitive complex reflection groups
Authors: Randriamaro H.
Published: October 2021

In 1994, M. Bożejko and R. Speicher proved the existence of completely positive quasimultiplicative maps from the group algebra of Coxeter groups to the set of bounded operators. They used some of them to define an inner product associated to creation and annihilation operators on a direct sum of Hilbert space tensor powers called full Fock space. Afterwards, A. Mathas and R. Orellana defined in 2008 a length function on imprimitive complex reflection groups that allowed them to introduce an analogue to the descent algebra of Coxeter groups. In this article, we use the length function defined by A. Mathas and R. Orellana to extend the result of M. Bożejko and R. Speicher to imprimitive complex reflection groups, in other words to prove the existence of completely positive quasimultiplicative maps from the group algebra of imprimitive complex reflection groups to the set of bounded operators. Some of those maps are then used to define a more general inner product associated to creation and annihilation operators on the full Fock space. Recall that in quantum mechanics, the state of a physical system is represented by a vector in a Hilbert space, and the creation and annihilation operators act on a Fock state by respectively adding and removing a particle in the ascribed quantum state.
Gel Chromatographic Examination of Serum of Rats and Hamsters Under Artificial and Natural Hibernation
Authors:   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Shylo Oleksandr , Lomako Viktoria ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Semenchenko Oleksandr ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine
Published: October 2021

In this study, molecular composition of hamster and rat blood was studied by gel permeation chromatography under natural (NH) and artificial hibernation (AH). The control group was represented by 5 fractions of molecules in hamsters and 7 in rats. The areas under peaks of the fractions similar in molecular weight in hamsters and rats were larger in rats. NH was characterized by appearance of new fractions (1,350, 2,350, and 6,350 Da) and an increase in areas under peaks of the control fractions (1,140 and 1,980 Da). Artificial hibernation in rats led to an increase in areas under peaks of 1,140 Da fraction, a decrease in that of 530 Da, and disappearance of 1290 Da, as well as the appearance of new fractions (650, 830, 950, 2350, and 5110 Da). Two hrs of later AH, the areas under peaks of 1,140 and 1,520 Da fractions were greater and that of 530 Da was lesser; 650, 2,350 and 5,110 Da fractions disappeared, 1,290 Da reappeared and new fraction of 4,030 Da appeared. New fractions of 5,820 and 6,530 Da were found 24 hrs later. In hamsters under AH, the areas under peaks of 1,140, 1,600, and 3,330 Da increased; as well as a new peak in 5,280 Da appeared, both in the control rats and those in 24 hrs after AH.
Placental Cryoextract and Renin-Angiotensin-Aldosterone System Blockade Mitigate Renal Failure in Rats
Authors:   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Repin Mykola , Chyzh Yuliia ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Marchenko Larysa ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine, Govorukha Tetyana ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine, Brusentsov Oleksandr ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine
Published: October 2021

Here, we have studied the impact of administration of rat placental cryoextract (PCE), drug blockade of the renin-angiotensin-aldosterone system (RAAS) with enalapril and spironolactone and their combination on the rat kidney tissue structure and excretory function at different stages of chronic renal failure (CRF) development using the glycerol model. In 3 weeks after glycerol introduction, the animals from all the groups showed low values of glomerular filtration rate, impaired blood flow in renal cortex, tubular epithelial dystrophy, inflammation and edema of interstitium, indicating the onset of CRF development. Tubulo-interstitial nephritis and nephrosclerosis were dominated in untreated rats 16 weeks later. The use of RAAS drug blockade, as well as a comprehensive therapy with RAAS blockers and placental cryoextract stopped the inflammatory processes in renal tissue, restored blood circulation and normalized excretory function, which persisted for up to 16 weeks of observation.
Cultural Properties of Cryopreserved Thymic Multipotent Stromal Cells and Fetal Skin and Muscle-Derived Cells
Authors:   Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Nikolska Valentina , Semenova Yanina-Maria ,   Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Taranukha Lyuba ,   Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Nikolsky Ihor ,   Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv
Published: October 2021

The paper provides a comparison of properties of cryopreserved fetal murine multipotent stromal cells (MSCs) of skin-muscular origin and those derived from adult thymus in culture in vitro. Fetal MSCs showed a 30% higher number of average population doublings within 24 hrs, and 41% lower average population doubling time. It was found that the fetal MSCs of the 4th passage had a 39% higher clonogenic activity than the adult thymus-derived ones. Fetal MSCs and those derived from adult thymus differentiated in osteogenic and adipogenic lineages with equal efficiency in special culture media. Fetal and thymus-derived MSCs were characterized by almost the same high ability of contact interaction with thymocytes, and the fibroblast-lymphocyte rosette (FLR) formation. They were far less active in FLR formation with lymph node cells. This indicated the presence of membrane affinity for immature lymphoid cells in both MSC subpopulations. The results showed the fetal MSCs to be significantly different from the adult thymus-derived MSCs by more active kinetics of growth and clonogenic potential. However, both cell subpopulations had virtually the same ability for linear differentiation and showed high activity during contact with immature lymphoid cells. Linear differentiation and the ability to interact with lymphocytes were found to be quite stable properties of MSCs, but a proliferative activity and in vitro colony formation distinguished significantly in different types of MSCs. This can be taken into account when choosing the cells for therapy, research and results assessment.