bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of river water inflow on the growth, photosynthesis, and respiration of the tropical seagrass Halophila ovalis
Authors: Lamit Nadhirah , Tanaka Yasuaki
Published: March 2021

To investigate the effects of river waters on estuarine seagrass, the tropical seagrass Halophila ovalis was collected at Brunei Bay, Borneo, and was cultured under laboratory conditions for 18 days. Three treatments were set up in the experiment: natural seawater with a salinity 30 (S30), estuarine river water with a salinity 10 (S10), and the intermediate water that was composed of the seawater and river water with a salinity 20 (S20). New leaf production, the average length of new leaves, rhizome elongation, and photosynthetic rate of H. ovalis were significantly higher in S20 than S10. Chlorophyll a (chl a) and carotenoid content in H. ovalis were significantly lower in S10 than S20 and S30. Though the tropical river waters could potentially cause both positive and negative effects on seagrass, the present results suggested that low salinity would be the most influential factor to hinder the growth and metabolism of H. ovalis, and the salinity threshold was observed between 10 and 20. These results suggested that H. ovalis may be able to extend its present distribution to the upper estuary at this study site in the future.
Efficacy and safety of therapeutic plasma exchange in stiff person syndrome
Authors: Czempik Piotr F. , Gawryluk Justyna , Wiórek Agnieszka , Krzystanek Ewa , Krzych Łukasz J.
Published: March 2021

The stiff person syndrome (SPS) is an extremely rare neurological disorder with primarily immune-mediated etiology. The cardinal symptoms are progressive, fluctuating axial/proximal limb muscle stiffness and spasms. The diagnosis is based on the clinical picture, electromyography examination and detection of antibodies to glutamic acid decarboxylase (anti-GAD). Adverse effects of medications might preclude its use or increase in dosing, therefore symptomatic and/or immunomodulatory medical therapy might be ineffective in acute exacerbation of the disease. We present a case of a 49-year-old female with exacerbation of SPS, in whom some standard pharmacotherapy could not be introduced (clonazepam, baclofen used in the past) and doses of existing standard medications could not be increased (diazepam, gabapentin, and levetiracetam) due to adverse effects. Moreover, a newly introduced medication (methylprednisolone) also led to a serious adverse effect (severe hyperglycemia). The patient underwent therapeutic plasma exchange (TPE) with good effect and no complications. We review the literature regarding the efficacy and safety profile of TPE in exacerbation of SPS unresponsive to medical therapy. The procedure seems to have a good safety profile as an adjunct therapy for exacerbation of SPS not responding to standard medical therapy in this patient population.
Crystal structure of 2-phenylethynyl-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1H-pyrrol-2-yl)methylene)hydrazine), C22H20B2F4N4
Authors: Liu Yingfan , Sun Saisai , Ji Guangqian , Li Xiaochuan , Son Young-A
Published: March 2021

C22H20B2F4N4, orthorhombic, Pbca (no. 61), a = 9.2506(2) Å, b = 36.1677(13) Å, c = 12.9475(3) Å, V = 4331.9 Å3, Z = 8, R

gt
(F) = 0.0729, wR

ref
(F
2) = 0.1992, T = 294.4 K.
Variété et complexité des situations de travail et reconnaissance des acquis de métier: le travail des experts-évaluateurs
Authors: Holgado Otilia , Allard-Martin Charles
Published: March 2021

Cet article examine le travail des professionnels expérimentés qui agissentà titre d’experts-évaluateurs dans le cadre du processus dereconnaissance des acquis de métier (RAM) au baccalauréat enenseignement professionnel (BEP) dans une université québécoise.Partant du constat que les concepts de « variété » et de « complexité » dessituations de travail se situent au centre de l’activité évaluative, cet articletente de montrer comment ces concepts sont construits et mobilisés parles experts-évaluateurs dans l’analyse des dossiers des étudiantscandidats à la RAM. Pour finir, l’article propose quelques pistes pour laformation des experts-évaluateurs, dans une visée d’homogénéisation despratiques évaluatives.
Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition
Authors: Yu Cheng-Long , Li Jin-Nan , Gan Ping , Wang Li-Ping , Yang Yue-Xiong , Yu Da-Fu , Mao Rong-Rong , Xu Fu-Qiang , Zhou Qi-Xin , Richter-Levin Gal , Xu Lin , Zhou Heng
Published: March 2021

Circuit compensation is often observed in patients with acute ischemic stroke, suggesting the importance of the interaction between brain regions. Also, contextual fear memory is an association between multisensory contexts and fearful stimuli, for which the interaction between the hippocampus and the amygdala is believed to be critical. To understand how focal ischemia in one region could influence the other region, we used a modified photo-thrombosis to induce focal ischemia in the hippocampus or the amygdala or both in freely-moving rats. We found that the learning curve and short-term memory (STM) were not affected in the rats although focal ischemia was induced 5 h before learning in either the hippocampus or the amygdala; these were impaired by the induction of ischemia in both the regions. Furthermore, the learning curve and STM were impaired when ischemia was induced 24 h before learning in either the hippocampus or the amygdala when the synaptic transmission was altered in one region because of ischemia in the other region. These results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition.
Selective Ablation of BDNF from Microglia Reveals Novel Roles in Self-Renewal and Hippocampal Neurogenesis
Authors: Harley Samuel B. R. , Willis Emily F. , Shaikh Samreen N. , Blackmore Daniel G. , Sah Pankaj , Ruitenberg Marc J. , Bartlett Perry F. , Vukovic Jana
Published: March 2021

Microglia, the resident immune cells of the CNS, have emerged as key regulators of neural precursor cell activity in the adult brain. However, the microglia-derived factors that mediate these effects remain largely unknown. In the present study, we investigated a role for microglial brain-derived neurotrophic factor (BDNF), a neurotrophic factor with well known effects on neuronal survival and plasticity. Surprisingly, we found that selective genetic ablation of BDNF from microglia increased the production of newborn neurons under both physiological and inflammatory conditions (e.g., LPS-induced infection and traumatic brain injury). Genetic ablation of BDNF from microglia otherwise also interfered with self-renewal/proliferation, reducing their overall density. In conclusion, we identify microglial BDNF as an important factor regulating microglia population dynamics and states, which in turn influences neurogenesis under both homeostatic and pathologic conditions.

SIGNIFICANCE STATEMENT(1) Microglial BDNF contributes to self-renewal and density of microglia in the brain. (2) Selective ablation of BDNF in microglia stimulates neural precursor proliferation. (3) Loss of microglial BDNF augments working memory following traumatic brain injury. (4) Benefits of repopulating microglia on brain injury are not mediated via microglial BDNF.
How Informal Education Fosters Economic Awareness in Children
Authors: Rahmatullah Rahmatullah , Inanna Inanna , Ampa Andi Tenri
Published: March 2021

The research aimed to find out how the education pattern in the family forms children's economic awareness. Qualitative descriptive was used as an approach in this study to reveal how the role of farmer families in the Maritengngae sub-district, Sidrap Regency in fostering economic awareness in their children. The number of informants in this study was 10 people. The data collection used observation, documentation, and interviews. The results showed that economic education was part of education that took place in the family environment to foster economic awareness in children from an early age through habituation, exemplary and transfer of knowledge. The characteristics of economic education in the family can be seen in various aspects, namely giving verbal advice, participating in shopping, and habituation in saving, limiting pocket money, and priority scale in fulfilling needs. The role of housewives is very important in fostering habits and role models in children from an early age with the hope that in the future they will become responsible economic actors.
The Effectiveness of Digital Literacy in Economic Learning
Authors: Prasetyo P. Eko , Anggraeni Oki
Published: March 2021

The purpose of this research is to increase studentsâ€™ economic learning interest and outcomes using digital literacy technology, such as Sparkol Video Scribe (SVc) and media chart (MC). This is an experimental research comprising of the control and treatment classes with international trade discussed as a sub-topic of the economic material. The learning activities method used the ADDIE model. While, the research subjects are high school students in Central Java. N-Gain model was used to determine the most effective level of analysis as well as the modification and path analysis. The main results showed that the application of SVc and MC learning models can attract students' interest in economic learning well. Although the SVc application was not effective in improving their overall performance, the MC literacy model was still effective. However, students' interest in learning about the second model has not been able to improve its performance significantly. The results further showed that the digital literacy method was not always able to improve student learning and performance effectively and efficiently.
Spatial Interaction Based on Sub-District Development Index in Pandeglang Regency
Authors: Wulandono Okta , Rustiadi Ernan , Ardiansyah Muhammad
Published: March 2021

Population movement is a form of spatial interaction between regions. This phenomenon arises asa logical consequence of the heterogeneity of regional development that occurs. PandeglangRegency as an underdeveloped area should not be left behind because of the many leaks of spatialinteractions that are more directed outside this district. Investigating the daily mobilization of thepopulation internally is important in determining which sub-districts play a role as a destination foreconomic activity. The basic data used include the survey origin destination of Banten Province in2019 and data on Potential Villages (Podes) 2019 in the Pandeglang Regency. The method used isthe Scalogram method to determine the Sub-District Development Index (SDI) and the gravitymethod to analyze spatial interactions. The Hierarchical classification was carried out on the SDIvariable, the number of daily movements (density), and the distance between districts. This is doneto see the intensity of the daily movement of the population according to density, distance, andSDI hierarchy class. The spatial interaction magnitude is estimated based on the populationestimation parameters and SDI through the natural logarithmic transformation (ln) of the gravitymethod formula. The results show that the highest average population movement occurs in thehigh-density hierarchy leading to the sub-districts of the SDI 1 hierarchy. The sub-districts ofCadasari, Munjul, Patia, Saketi, and Sukaresmi as sub-districts from which spatial interactionoriginate will produce positive intensity values when compared to other sub-districts. CadasariSub-District will provide a positive spatial interaction value when it becomes the goal of the dailymovement of the population.
Large Dams and Welfare : Empirical Study in Indonesia
Authors: Aribowo Gunawan , Yudhistira Muhammad Halley
Published: March 2021

In addition to solving the problem of water shortage for irrigation, energy and consumption, thepolicy of building large dam is also expected to improve population-welfare. However, previousstudies suggest that people living near dams have less benefit from the existence of large dam. Thisstudy aims to provide empirical evidence the effect of large dam development on welfare tohousehold living in sub-districts around large dam placement using National Socio-EconomicSurvey (SUSENAS) data in 2013-2018 from Central Bureau of Statistics and spatial large dam datain Indonesia. Estimated results indicate that addition large dam tend to be negatively correlated by2.4-3.1 % with household consumption implying a tendency of decreasing welfare in localhouseholds. Estimated findings using Indonesia Family Life Survey (IFLS) in 2007 and 2014 shownegative correlation likely to be caused by lower agricultural productivity and work activity. Thisresult show there are economic agents who suffer from large water - infrastructure especiallyhouseholds living in sub-districts close to the dam.
Is Educated Labor Really Productive?
Authors: Sugiharti Rr Retno , Islami Fitrah Sari , Pramudiastuti Octavia Laksmi
Published: March 2021

Improving the quality of human resources through education is believed to increase laborproductivity. The higher the investment in education, the greater the potential for someone to gainknowledge, expand access to jobs, and increase productivity. However, the increases in the numberof educated workforces, truly unbalanced with the increase with aggregate productivity. Thepurpose of this study is to analyze at which one of the levels of education has the greatestcontribution to increasing productivity. In order to bring the research in macro level, we usedMincer equation calibrated by Bils and Klenow (2000) to develop a human capital model. Thiskind of research formed in micro level and very rarely research is done at the macro level.Therefore, by using calibration from Bils and Klenow (1992), this study tries to bring the mincermodel to the macro level. This model estimates by panel regression method and cointegrationmethod (for identification long run existence) and using data from the period of 2010-2018. Theresults of the study show a positive integration between the level of education towards workproductivity. The fact that vocational education is aimed at preparing workforce has no significanteffect on aggregate productivity. The result driven us to conclusion that education has not beenconsidered a human capital factor but signaling factor; schooling level of labor was not a drivenfactor to labor productivity, but the years of experience did and labor is tended to taking educationjust for formal reason not for academic reason.
Impacts of Indonesian Economic Growth: Remittances Migrant Workers and FDI
Authors: Ukhtiyani Khairah , Indartono Setyabudi
Published: March 2021

This study aims to identify: (1) the effect of remittance of Indonesian workers on Indonesia's economic growth from 1998-2018; (2) the effect of Foreign Direct Investment on Indonesia's economic growth from 1998-2018; and (3) the effect of remittances of Indonesian workers and Foreign Direct Investment (FDI) on Indonesia's economic growth from 1998-2018. Based on previous studies found differences in the results of contributions. This study uses a quantitative model using remittances from Indonesian workers and FDI as independent variables, and the dependent variable is economic growth. The population of this study is all secondary data about the percentage of GDP and FDI remittances and the level of economic growth in Indonesia in 1998-2018. Tests conducted are prerequisite tests for multicollinearity, heteroscedasticity, autocorrelation, and multiple regression hypothesis testing using SPSS 21 to measure the effect of independent variables on the dependent variable partially and simultaneously. The results of this study stated that there was no significant effect on the remittance of Indonesian workers and FDI on Indonesia's economic growth from 1998-2018 because the receipt of remittances by Indonesian workers was used by households for food consumption and expenditure, not for investment or to open businesses. Meanwhile, Indonesia's FDI bureaucracy is still inefficient and there is a need for infrastructure development to increase foreign investor interest. In addition, Indonesia is still oriented towards imports rather than exports.
Assessing Sharia Monetary Instruments Against Country Economic Growth
Authors: Wahid Arfian Nur , Jamel Surono Bin , Noviarita Heni , Anggraini Erike
Published: March 2021

This study aims to examine the effect of Islamic monetary instruments on Indonesia's economic growth. Statutory Reserves, Bank Indonesia Syariah Certificate (SBIS) and Outstanding Deposit Facility Syariah (FASBIS) are used as sharia monetr instrument variables in observations. this study is a quantitative study using monthly time series data obtained from the publication of Bank Indonesia and the Indonesian statistical agency in 2015-2019 using ARDL analysis. The results of this study indicate that both short-term and long-term modeling, instrument variables Islamic monetary does not have a significant relationship on economic growth. Although it has a very small effect, the Demand Deposits variable has an effect on the Indonesian economy, while the other variables observed have an inverse relationship with the variable of Indonesia's economic growth. the achievement of monetary stability through sharia monetary instruments can be optimized using policies on the minimum statutory reserves in banks that are useful for controlling the circulation of the amount of money in society so that it is more stable and the Indonesian economy can grow through the middle income trap.
Corruption and Economic Growth in West Africa
Authors: Ighodaro Clement Atewe , Igbinedion Sunday Osahon
Published: March 2021

The level of corruption in West Africa has become very worrisome based on the data from the corruption perception index of transparency international. Corruption may subvert due process; reduce accountability; lead to unequal distribution of goods and services and limit the reliance of the masses on government. The objective of the paper was to examine the link between corruption and economic growth in West Africa. Data used span from 2000 to 2018 with a cross section of fifteen West Africa countries and the use of panel fully modified ordinary least squares. With the use of the Im, Pesaran, and Shin stationarity which allows for heterogeneous version of the Dickey Fuller test, it was found that the variables used were integrated of order one and long run equilibrium relationship existed based on the Pedroni cointegration method. Only foreign direct investment did not meet the a priori expectation. The result supports the ‘grease on the wheel hypothesis’. This implies that corruption and economic growth have direct relationship in West Africa. Corruption and economic growth were found to also support the U-shaped hypothesis which means that different corruption level affect economic growth in different ways. However, corruption does not lead to efficient and effective outcomes hence should not be allowed at any level of governance.
Opportunities of Using Information and Communication Technology in Reducing Poverty
Authors: Ruhyana Nugrahana Fitria , Essa Wiedy Yang
Published: March 2021

The development of Information and Communication Technology (ICT) is believed to improve the quality of human life, reduce inequality, and encourage the acceleration of poverty reduction. ICT can be developed as an alternative poverty alleviation program. The purpose of this study was to determine the opportunities of utilization of ICT in reducing poverty in Sumedang Regency and Bandung City. This study used quantitative methods with sources taken from National Socio-Economic Survey (Susenas) data in 2018. The data was analyzed by the Probit Regression method. ICT variables consisted of the ownership of cellular phones, computer use, and internet access. The results of the econometric model indicate that ICT can reduce the likelihood of poverty after being controlled by other related variables such as age, gender, education level, number of household members, access to business credit, and employment status. The government is expected to synergize with stakeholders to improve public services integrated with poverty reduction through the use of ICT, educating the public with productive internet, and expanding the development of ICT infrastructure.
Cash For Work? Extreme Poverty Solutions Based on Sustainable Development
Authors: Effendi Ghina Nabilah , Purnomo Eko Priyo , Malawani Ajree Ducol
Published: March 2021

This article discusses how cash for work and the goals of sustainable development as solutions to extreme poverty. Lack of employment in villages is a factor in poverty in Indonesia. The cash for work program is an innovation of the central government and village government with village funds to provide productive activities to reduce poverty, and as a commitment of Indonesia to implement global goals, namely sustainable development goals. The research was conducted in the Village of Mekar Sari Ness, Village that implemented the program and faced challenges of poverty and unemployment. This study uses qualitative methods with descriptive statistical analysis using Nvivo12 plus data processing applications and using crosstab analysis. Sources of data obtained through government websites and application services, report documents, and journalism-related to the matter to be examined. This research concludes program cash for work can increase income per capita following SDGs standards, can open employment opportunities, especially for the rural poor and have a significant impact on optimizing village funds. Challenges going forward are managing village funds that must be in line with Ministry regulations, recruitment of workers and skills aimed at the poor and marginalized, as well as timeliness in implementing programs.
Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration
Authors: Perlman Barry E , Merriam Audrey A , Lemenze Alexander , Zhao Qingshi , Begum Salma , Nair Mohan , Wu Tracy , Wapner Ronald J , Kitajewski Jan K , Shawber Carrie J , Douglas Nataki C
Published: March 2021

In the first trimester of human pregnancy, low oxygen tension or hypoxia is essential for proper placentation and placenta function. Low oxygen levels and activation of signaling pathways have been implicated as critical mediators in the promotion of trophoblast differentiation, migration, and invasion with inappropriate changes in oxygen tension and aberrant Notch signaling both individually reported as causative to abnormal placentation. Despite crosstalk between hypoxia and Notch signaling in multiple cell types, the relationship between hypoxia and Notch in first trimester trophoblast function is not understood. To determine how a low oxygen environment impacts Notch signaling and cellular motility, we utilized the human first trimester trophoblast cell line, HTR-8/SVneo. Gene set enrichment and ontology analyses identified pathways involved in angiogenesis, Notch and cellular migration as upregulated in HTR-8/SVneo cells exposed to hypoxic conditions. DAPT, a γ-secretase inhibitor that inhibits Notch activation, was used to interrogate the crosstalk between Notch and hypoxia pathways in HTR-8/SVneo cells. We found that hypoxia requires Notch activation to mediate HTR-8/SVneo cell migration, but not invasion. To determine if our in vitro findings were associated with preeclampsia, we analyzed the second trimester chorionic villous sampling (CVS) samples and third trimester placentas. We found a significant decrease in expression of migration and invasion genes in CVS from preeclamptic pregnancies and significantly lower levels of JAG1 in placentas from pregnancies with early-onset preeclampsia with severe features. Our data support a role for Notch in mediating hypoxia-induced trophoblast migration, which may contribute to preeclampsia development.
Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis
Authors: Wang Tse-En , Minabe Shiori , Matsuda Fuko , Li Sheng-Hsiang , Tsukamura Hiroko , Maeda Kei-Ichiro , Smith Lee , O’Hara Laura , Gadella Bart M , Tsai Pei-Shiue
Published: March 2021

The epididymis is an androgen-responsive organ, whose structure and functions are modulated by the coordination between androgen and epididymal cues. Highly regulated molecular interaction within the epididymis is required to support viable sperm development necessary for subsequent fertilization. In the present study, we extended our earlier findings on a promising epididymal protein, quiescin sulfhydryl oxidase 2 (QSOX2), and demonstrated a positive correlation between testosterone and QSOX2 protein synthesis through the use of loss- and restore-of-function animal models. Moreover, based on transcriptomic analyses and 2D culture system, we determined that an additional polarized effect of glutamate is indispensable for the regulatory action of testosterone on QSOX2 synthesis. In conclusion, we propose noncanonical testosterone signaling supports epididymal QSOX2 protein synthesis, providing a novel perspective on the regulation of sperm maturation within the epididymis.
CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia
Authors: Zhang Yu-chen , Qin Xiao-li , Ma Xiao-ling , Mo Hui-qin , Qin Shi , Zhang Cheng-xi , Wei Xiao-wei , Liu Xue-qing , Zhang Yan , Tian Fu-ju , Lin Yi
Published: March 2021

Preeclampsia is a gestational hypertensive disease; however, preeclampsia remains poorly understood. Bioinformatics analysis was applied to find novel genes involved in the pathogenesis of preeclampsia and identified CLDN1 as one of the most differentially expressed genes when comparing patients with preeclampsia and healthy controls. The results of the qRT-PCR, Western blotting and immunohistochemistry experiments demonstrated that CLDN1 was significantly downregulated in the chorionic villi in samples from patients with preeclampsia. Furthermore, knockdown of CLDN1 in HTR-8/SVneo cells resulted in the inhibition of proliferation and induction of apoptosis, and overexpression of CLDN1 reversed these effects. In addition, RNA-seq assays demonstrated that the gene BIRC3 is potentially downstream of CLDN1 and is involved in the regulation of apoptosis. Knockdown of CLDN1 confirmed that the expression level of BIRC3 was obviously decreased and was associated with a significant increase in cleaved PARP. Interestingly, the apoptotic effect in CLDN1 knockdown cells was rescued after BIRC3 overexpression. Overall, these results indicate that a decrease in CLDN1 inhibits BIRC3 expression and increases cleaved PARP levels thus participating in the pathogenesis of preeclampsia.
Synthesis of fluorescently-labelled poly(2-ethyl-2-oxazoline)-protected gold nanoparticles
Authors: Nurgaziyeva Elmira , Kudaibergenov Sarkyt , Mun Grigoriy , Khutoryanskiy Vitaliy
Published: March 2021

Gold nanoparticles (GNPs) protected by poly(2-ethyl-2-oxazoline) (POZ) of different molecular weights (Mw = 5, 50, 200 and 500 kDa) were synthesised and characterised by dynamic light scattering, nanoparticle tracking analysis, zeta potential measurement and transmission electron microscopy. It was established that the use of POZ with 50 kDa resulted in formation of GNPs with low polydispersity while POZ with greater molecular weights led to formation of more polydisperse GNPs. Fluorescent labelling of these nanoparticles was achieved through their reaction with polyethyleneglycol dithiol (8-12 kDa) as a linker molecule with subsequent reaction with 6-(iodoacetamido) fluorescein. The fluorescent nature of obtained GNPs was confirmed by the appearance of the fluorescence peak at 510 nm that is typical for fluorescein molecules and glowing of the aqueous solution under the UV irradiaton. The fluorescently-labelled GNPs are promising tool in biomedical application to monitor the biological systems using fluorescent microscopy.
Finansinio sverto apskaičiavimas ir interpretavimas
Authors: Mackevičius Jonas , Poškaitė Dalia
Published: March 2021

Straipsnyje nagrinėjama labai svarbaus įmonės finansinės veiklos vertinimo rodiklio – finansinio sverto apskaičiavimo metodika. Įvairūs užsienio ir Lietuvos autoriai skirtingai vertina, interpretuoja ir įvardija šį rodiklį, pateikia skirtingus jo apskaičiavimus. Analizuojamos įvairių autorių nuomonės, įrodoma, kad finansinis svertas yra vienas, o ne daugelis rodiklių, kad jis išreiškia skolinto ir nuosavo kapitalo santykį ir yra svarbus ne tik įmonės mokumui ir pelningumui, bet ir racionaliai kapitalo struktūrai užtikrinti.
Из проблематики формирования балтийских и славянских этнонимов
Authors: Каралюнас Симас
Published: March 2021

В докладе обсуждаются некоторые спорные вопросы формирования балтийских и славянских племенных названий на балто-славянском языковом пограничье. Лингвоэтнические процессы, происходившие на стыке двух этносов в условиях взаимодействия в течение долгих веков, обусловили специфику формирования как балтийских, так и славянских этнических названий, которые не всегда можно однозначно отнести к одному или другому лингвоэтносу. Новые идеи и новый материал в балтистике и славистике, появившиеся в результате исследований последних десятилетий, делают возможным пересмотр имеющихся гипотез и интерпретаций, при соблюдении, однако, метода внутренней реконструкции как основного. В докладе внимание уделяется прежде всего происхождению названия белоруса (иногда поляка или русского) в литовском языке, а также объяснению племенного названия Golensizi в Географе Баварском.
Early immune reconstitution assessment by flow/mass cytometry in autologous hematopoietic transplantation performed in a patient with multiple myeloma
Authors: Villegas-Valverde Carlos Agustín , Ventura-Carmenate Yendry , M Alkaabi Fatima , Bencomo-Hernández Antonio
Published: March 2021

Evaluation of immunoprofile as predictive and prognostic biomarker are essential to follow up patients in Multiple Myeloma after autologous hematopoietic stem cells transplantation (AHSCT). It can be defining the engraftment and predicts complications. An AHSCT was performed for the first time in the United Arab Emirates to treat a patient with multiple myeloma. We apply the evaluation of the patient's immune status before and during the early follow-up by flow and mass cytometry. The analysis revealed a decrease in all leukocyte populations in blood seven days after transplantation, mainly of B and T helper lymphocytes. The patients showed diarrhea and cellulitis as complications. An increase in regulatory T and NK lymphocytes was evidenced at the same time. 28 days’ post-transplantation, all lymphocyte populations were recovered, except for B lymphocytes, a high level of T regulatory and NK was maintained. The early immune restoration coincided with the recovery of the complications presented by the patient. the leukocyte composition of apheresis was similar to that found in blood at baseline time. Our study evidenced that the extended immunoprofile by mass cytometry could be useful to predict the outcome and response to transplantation.
The Beginning of the Palaeoeconomics Study in Ukrainian Archaeology (to the 100th Anniversary of B. A. Shramko’s Birth)
Authors:   National Academy of Science of Ukraine, Institute of Archaeology, DSc, Leading Researcher, Gavrylyuk Nadia
Published: March 2021

Almost all models of the palaeoeconomical researches used by representatives of the world economic science are suitable for studying the economic systems of antiquity. Interdisciplinary research, which combines the techniques and methods of research in economics and archaeology, seems to be very productive. This trend in the English language literature has been recorded only since 1990-ies. In Ukrainian archaeology it originated much earlier. On the example of the scientific biography of Borys Andriiovych Shramko, Doctor of Historical Sciences, the founder of the Kharkiv Archaeological school, who would have turned 100 in January 2021, the formation of the palaeoeconomic direction can be traced. The main problems that were posed and solved by the researcher are shown. It is noted that all the activities of the scientist were «targeted» in nature, i.e. before the start of excavations of the complex of the archaeological monuments in the vicinity of the Bilsk hill-fort, the largest settlement structure in Eastern Europe, B. A. Shramko set himself the task of studying the economic system of the region. The achievements of the scientist in the study of agriculture, cattle breeding, crafts, domestic crafts, construction are shown. To study these branches of the economy, the methods of natural sciences were widely used, i.e. research by B. A. Shramko, since 1960-ies have had an interdisciplinary character. It is concluded that B. A. Shramko was the first in Ukraine who conducted a study of the palaeoeconomics using the method of economic research. Moreover, it can be noted that B. A. Shramko proved the participation of the region he studied in the world-system structures that developed in the early Iron Age.
Analisis dan Perancangan Sistem Informasi Inventory Barang pada PT Cipta Rasa Multindo S
Authors: Nuryasin Nuryasin , Saputra Alvin Handrianto , Hardi Tomi , Fadholur Irfan
Published: March 2021

Cipta Rasa Multindo merupakan perusahaan manufaktur yang bergerak di bidang produksi pastry dan bakery. Sebagai perusahaan manufaktur pengelolaan inventory sangatlah penting untuk meningkatkan kinerja perusahaan dalam mengelola stok barang. Saat ini sistem inventory yang berjalan masih manual dan memiliki banyak kelemahan dan kekurangan sehingga menyebabkan kinerja perusahaan menjadi terhambat dan belum mampu menunjang segala kebutuhan yang diinginkan perusahaan seperti proses mulai dari pencatatan barang hingga perekapan laporan yang cukup memakan waktu. Penelitian ini bertujuan untuk menganalisis dan merancang suatu sistem informasi inventory barang yang dibutuhkan oleh perusahaan. Metode analisis Performance, Information, Economy, Control, Eficiency, dan Service (PIECES) digunakan untuk membantu proses analisis sistem yang berjalan. Merancang dan mendesain sistem informasi inventory barang menggunakan metode Rapid Application Development (RAD) sebagai metode pengembangan sistem dan Unified Modelling Language (UML) sebagai alat pemodelannya. Dengan dikembangkannya analisis dan perancangan sistem ini mampu meningkatkan kinerja perusahaan menjadi lebih efektif dan efisien.
Perencanaan Strategi Sistem Informasi pada PT Indonesia Stanley Electric dengan Pendekatan Ward & Peppard
Authors: Wahyuningsih Melysa , Waspodo Bayu
Published: March 2021

PT Indonesia Stanley Electric (PT ISE) merupakan perusahaan manufaktur yang melayani kebutuhan business to business (B2B) dengan memproduksi kebutuhan kebutuhan alat penerangan baik roda dua maupun roda empat. Tidak dapat dipungkiri bahwa saat ini daya saing PT ISE tak hanya datang dari perusahaan dalam negeri melainkan juga datang dari luar negeri. Masih kurangnya SDM yang memenuhi beberapa unit kerja menjadi permasalahan yang dihadapi oleh perusahaan untuk memaksimalkan aset yang dimilikinya. Untuk itu dilakukan sebuah penelitian berupa Perencanaan Strategi Sistem Informasi menggunakan pendekatan Ward dan Peppard. Perencanaan strategi sistem informasi ini dilakukan dengan menganalisis lingkungan bisnis internal dan lingkungan bisnis eksternal, dan analisis lingkungan SI/TI internal dan lingkungan SI/TI eksternal. Sedangkan tools ynag digunakan adalah analisis CSF (Critical Success Factor), SWOT, Value Chain, BMC (Business Model Canvas), PESTEL, Porter’s Five Forces, dan McFarlan’s Strategy Grid. Hasil dari penelitian ini berupa Strategi Bisnis Sistem Informasi, Strategi Teknologi Informasi, dan Strategi Manajemen SI/TI yang dapat menjadi acuan bagi perusahaan untuk mewujudkan visi, misi, dan tujuan serta meningkatkan daya saingnya.
Analisis Perancangan Sistem Informasi Pendaftaran Siswa Baru (PSB) Kafila International Islamic School
Authors: Septoaji Aditya Teguh , Subiyakto Aang
Published: March 2021

Kafila International Islamic School adalah sebuah pesantren yang mempunyai prestasi tinggi di tiap perlombaan dan nilai Ujian Nasional. Perekrutan siswa baru masih menggunakan metode lama, yaitu pemberkasan manual yang kemudian discan dan disimpan digital. Menggunakan cara tersebut untuk proses seleksi akan membutuhkan banyak sekali sumber daya baik manusia maupun alat. Dengan proes pendaftaran siswa baru saat ini yang masih manual membuat pekerjaan tidak efisien dan cenderung melakukan kesalahan karena ketidaktelitian pada pemberkasan. Ketidaktelitian tersebut menyebabkan beberapa kesalahan fatal, yaitu proses penerimaan siswa baru yang tidak efisien hingga hilangnya berkas siswa. Untuk menanggulangi itu, perlu sebuah sistem yang menangani pendaftran siswa baru, mulai dari data siswa, biografi siswa, hingga dokumen-dokumen siswa di sekolah. Maka dari itu, penulis membuat analisis dan perancangan Aplikasi  Sistem Informasi Pendaftaran Siswa Baru (PSB) Berbasis Web dengan menggunakan Pemodelan Unified Modelling Language (UML) sebagai Bahasa pemodelannya. Dengan adanya Racangan Sistem Informasi Pendaftaran ini, semoga dapat memberikan efisiensi waktu dan proses pendaftaran yang lebih rapih dan terdokumentasi.
THE Exploration of Effective Spatial Performance of Accessible Neighbourhood Green (Ang), Including its Proportion and Standard Distance from User in Dhanmondi Residential Area, Dhaka
Authors: Badhan I. M. , Ching S. W.
Published: March 2021

Urban physical context can be analyzed across three key matrixes (3-P) among others i.e. place, path, and people. So, pragmatic analysis of spatial effective performances connecting 3-P, require provoking frequency of people’s experience. Acknowledging this issue, the demand for accessible neighbourhood green (ANG) at an appropriate distance becomes the primary concern to enhance the quality of life and liveability in a city. However, with the continued urban growth and densification, the discrepancy between the demand and supply of open space continues to vary requiring adjustments to remain responsive. The real-life circumstance results in a shortage of parks and open areas in terms of demand and supply within accessible distance in Dhaka city. This paper intends to examine this issue through the case of the planned Dhanmondi Residential Area (DRA) in Dhaka. Despite having provision of multiple open spaces in DRA, visitor’s frequency varies due to age and gender group accessibility conditions and varying distances. Considering existing spatial norms set by Detail Area Plan (DAP), Dhaka structure plan (DSP), and numerous research works on Dhaka open spaces, the major inquiry posed here is whether these open spaces are appropriate for DRA or not. Therefore, the objective of this paper focuses on examining the quality of the physical environment of Neighbourhood public open spaces termed here as accessible neighbourhood green (ANG) in DRA to examine their adequacy concerning proportion and distance synchronized with the frequency of visits. The initial part of the paper focuses on conceptualizing the problem vis-à-vis the existing scenario.  Surveys and interviews have been conducted to assess people’s perceptions in terms of comfort, accessibility, sociability, and user frequency aligned with proximity. The result indicates that the provision of one appropriate ANG within two or three standard blocks apart contribute to enhancing the quality of life for the city dwellers and their liveability.
Niemann–Pick-betegség: saját megfigyelések és új terápiás lehetőségek
Authors: Erdős Melinda
Published: March 2021

Összefoglaló. A Niemann–Pick-betegség autoszomális recesszíven
öröklődő lizoszomális tárolási betegség, amelynek hátterében a savi
szfingomielináz enzim hiánya vagy csökkent aktivitása (A-, A/B- és B-típus),
illetve a Niemann–Pick C intracelluláris koleszterintranszporter fehérje
deficientiája (C- és D-típus) állhat. A defektus következtében szfingomielin és
koleszterin halmozódik fel a sejtek lizoszómáiban. A betegség leggyakoribb
prezentációs tünete a hepatosplenomegalia miatt elődomborodó nagy has. A
legsúlyosabb tünetek a progresszív neurodegeneráció következményei. A diagnózis
megerősítésében elengedhetetlen a genetikai vizsgálat, amely az érintett
családokban lehetőséget teremt praenatalis genetikai vizsgálatok végzésére is. A
betegség idejekorán történő felismerése rendkívül fontos, hiszen napjainkban a
terápiás lehetőségek egyre bővülnek. A szubsztrátredukciós, illetve enzimpótló
kezeléseknek köszönhetően a hepatosplenomegalia mérsékelhető, és lassítható vagy
visszafordítható a neurológiai tünetek progressziója. A szerző két
esetismertetésen keresztül mutatja be a Niemann–Pick-betegség főbb típusait,
klinikumát, molekuláris genetikai hátterét, és elemzi a diagnosztikus, illetve
terápiás lehetőségeket. Orv Hetil. 2021; 162(2): 74–80.

Summary. The Niemann–Pick disease is an autosomal recessive
lysosomal storage disorder caused by the lack or decreased activity of the acid
sphingomyelinase enzyme or a deficiency of the Niemann–Pick C intracellular
cholesterol transporter protein. As a result of the defect, sphingomyelin and
cholesterol accumulate in the lysosomes of the cells. The most common
presentation symptom of the disease is abdominal protrusion due to
hepatosplenomegaly. The most severe symptoms are the consequences of progressive
neurodegeneration. Genetic testing is essential to confirm the diagnosis, which
also allows for prenatal genetic testing in the affected families. Early
detection of the disease is extremely important as therapeutic options are
expanding. Thanks to substrate reduction and enzyme replacement therapies,
hepatosplenomegaly can be reduced, and progression of neurological symptoms can
be reversed. Through two case reports, the author presents the main types,
clinical manifestations, and molecular genetic background of this rare metabolic
disorder. The author describes the diagnostic and therapeutic approaches to
Niemann–Pick disease. Orv Hetil. 2021; 162(2): 74–80.
Egy különleges pancreaselváltozás: kevert differenciációjú nodularitás és diffúz szigetsejtes hyperplasia
Authors: Zalatnai Attila , Tőke Judit , Huszty Gergely , Müllner Katalin , Tóth Miklós
Published: March 2021

Összefoglaló. A szerzők egy különleges pancreaselváltozás esetét
ismertetik, melyben az acinusok neuroendokrin jellegű transzformációja diffúz,
atípusos megjelenésű szigetsejtes hyperplasiával társult, valamint a pancreas
mindhárom sejtvonalát (acinaris, ductalis, insularis) tartalmazó nodulusok
képződtek. A komplex megjelenés ellenére a kórfolyamat nem járt endokrin
tünetekkel. Esetünkben a kiváltó ok hátterében a struktúrák kóros
progenitorsejt-differenciációja állhatott. Az irodalomban ilyen közlés eddig nem
ismert. Orv Hetil. 2021; 162(6): 227–232.

Summary. The authors present a case of a peculiar pancreatic lesion,
in which the neuroendocrine transformation of the acini was associated with a
diffuse, atypical insular hyperplasia, and micronodules exhibiting trilineage
differentiation. Despite the complex alteration, no endocrine symptoms were
noted. The case may represent the result of an abnormal pancreatic
differentiation raising the possibility of reprogramming of the progenitor
cells. To the best of our knowledge, this is the first report of such a lesion
in the literature. Orv Hetil. 2021; 162(6): 227–232.
Az indociánzöld-fluoreszcencia hasznosítása az emlőrák miatt végzett őrszemnyirokcsomó-biopsziában
Authors: Venczel László , Maráz Róbert , Ambrózay Éva , Cserni Gábor , Sikorszki László
Published: March 2021

Összefoglaló.
Bevezetés: Napjainkban az őrszemnyirokcsomó felkeresésének
legelterjedtebb módszere a radioizotópos és kék festékes kettős jelölés,
emellett azonban több más jelölés is alkalmazható. Az
indociánzöld-fluoreszcencia ígéretes nyirokút-térképezési módszer, mely a
találati arányát tekintve – irodalmi adatok alapján – összevethető a
radioizotópos módszerrel. Módszer: Osztályunkon 2020. 03. 31.
és 2020. 04. 15. között 10, emlőrák miatt operált betegünknél alkalmaztuk az
indociánzöld és a kék festékes kettős jelölés módszerét az őrszemnyirokcsomó
felkeresésére. Eredmények: A 10 operált betegünknél összesen 17
őrszemnyirokcsomót azonosítottunk és távolítottunk el. 16 őrszemnyirokcsomó jól
festődött indociánzölddel (találati arány: 0,94; 95%-os konfidenciaintervallum
[CI ]: 0,73–0,99), míg kék festékkel 9 jelölődött (találati arány: 0,53; 95%-os
CI: 0,31–0,74). A szövettani feldolgozás során összesen 2 őrszemnyirokcsomó
bizonyult áttétesnek, ezek közül 1 kék és fluoreszcens volt, 1 pedig csak kék
festékkel jelölődött. Következtetés: Kezdeti, kis esetszámnál
nyert tapasztalataink alapján az indociánzöld jelölés emlőrák során végzett
őrszemnyirokcsomó-biopszia esetén jól használható kettős jelölési módszer
részeként, kék festékkel kiegészítve. A módszer találati aránya, valamint fals
negatív aránya irodalmi adatok alapján nem különbözik szignifikánsan a
radioizotópos jelölés módszerétől. Orv Hetil. 2021; 162(8): 293–297.

Summary.
Introduction: The current practice in sentinel lymph node
biopsy for breast cancer is the radioisotope and blue dye dual labelling
technique, however, other mapping methods are also available. Indocyanine green
fluorescence is one of the best alternatives of the standard technique, with
detection rates comparable to those of the radioisotope method.
Method: Between 31. 03. 2020 and 15. 04. 2020, a total of
10 sentinel lymph node biopsies for breast cancer were performed using the
indocyanine green fluorescence and blue dye dual technique.
Results: 17 sentinel lymph nodes were detected and removed
in total, from which 16 showed explicit fluorescence activity (detection rate:
0.94; 95% confidence interval [CI]: 0.73–0.99), whilst 9 where blue (detection
rate: 0.53; 95% CI: 0.31–0.74). During histopathological examination, 2 sentinel
lymph nodes proved to be metastatic, from which 1 was fluorescent and blue, the
other was blue only. Conclusion: Regarding our early experience
based on a small number of patients, indocyanine green fluorescence, used
together with blue dye as part of a dual technique, is a usable method for
sentinel lymph node mapping. Based on data from the literature, the detection
rate and the false-negative rate of the indocyanine green fluorescence method
shows no significant difference from the radioisotope mapping technique. Orv
Hetil. 2021; 162(8): 293–297.