bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Biological Aspects and Proline Metabolism Genes as Influenced by Polyethylene Glycol and Salicylic Aacid in Two Wheat Cultivars
Authors: Loutfy Naglaa , Hassanein Ahmed , Inouhe Masahiro , Salem Jehan
Published: November 2021

The aim of this work was to study the response of two wheat cultivars with different drought tolerance to PEG (-0.4 Mpa) and SA (0.5 mM). Data of seed germination and seedling growth indicated that Misr-2 cultivar was more drought tolerant than Gemmeiza-12. Under non- stress conditions, Misr-2 had higher values of pigments, soluble sugars (Glu, Fru and Suc) and activities of antioxidant enzymes (CAT, APOX, GPOX and SOD) but lower values of proline than those of Gemmeiza-12. The cultivar with a higher proline content (Gemmeiza-12) compared to the other cultivar had a higher expression of proline synthesizing gene (P5CS) but lower expression of proline degrading genes (PDH and P5CDH). Under drought conditions, the drought-sensitive (Gemmeiza-12) needed more osmoregulators and antioxidants than drought-tolerant cultivar (Misr-2) to minimize the negative effects of water and associated oxidative stresses. Therefore, soluble sugars, proline content and anti-oxidation enzymes were higher in Gemmeiza-12 than Misr-2. Also, under drought stress, up-regulation of P5CS and down-regulation of PDH and P5CDH in Gemmeiza-12 were higher than Misr-2. While treatment of the stressed plants with SA up-regulated P5CS gene in both cultivars, down-regulation of PDH and P5CDH in Gemmeiza-12 was clearer than Misr-2.
C-Reactive Protein Promotes Tumor Progression in Hepatocellular Carcinom by Interacting with Ephrin Type-B Receptor 3
Authors: She Sha , Yang Min , Li Shi Ying , Hu Huai Dong , Yang YiXuan , Ren Hong
Published: November 2021

Background

C-reactive protein (CRP), an acute phase protein, has been increasingly implicated in various tumors, and the role of CRP is positively correlated with invasion and metastasis in hepatocellular carcinoma cells. However, the mechanism of CRP affecting HCC progression remains poorly investigated. The present study investigated the role of CRP in HCC and the underlying mechanisms.
Methods

In the current study, CRP overexpression and suppression expression experiments were used to evaluate the effect of CRP on malignant biological behavior of liver cancer cells in vitro. Then iTRAQ-mass spectrometry analysis was used to identify CRP co-immunoprecipitation complexes. Detecting the interaction between CRP and Eph receptor B3 (EphB3) by co-precipitation. Moreover, immunofluorescence colocalization and co-precipitation, and Western Blot, in vivo model were applied to study the molecular mechanism of CRP affecting the development of Hepatocellular Carcinoma.
Results

We first found that CRP was significantly upregulated in HCC tissues and HCC cells, the expression level correlated with the metastatic ability of HCC cells. Knockdown of CRP significantly suppresses migration and invasion capacity in HCC cells. Through a proteomic analysis of CRP co-immunoprecipitation complexes, the EphB3 was identified as a new CRP interactor. Then we found that the expression and functions of EphB3 were consistent with CRP in HCC. In addition, co-immunoprecipitation and immunofluorescence assays suggested that EphB3 was able to interact with MAPK/ERK to activate MAPK/ERK signaling pathways. Furthermore, we showed that CRP can induce the phosphorylation of MAPK/ERK by binding EphB3. CRP also significantly stimulated MMP-9 expression, mainly by activating HIF-1α via the MAPK/ERK pathways.
Conclusions

Our findings showed that CRP increased HCC cells migration and invasion by binding EphB3 to activate MAPK/ERK signaling pathways. It suggested that CRP may become a prognostic factor and a potential therapeutic target for liver cancer.
Noteworthy Bio Resource Utilization and Eco-Friendly Bioconversion Approaches of Versatile Invasive Aquatic Weed Water Hyacinth (Eichhornia Crassipes) Biomass - A Green Strategy for Aquatic Environmental Safety and Management of Aquatic Weeds.
Authors: Selvaraj Karthick Raja Namasivayam , Vigneshwaraprakash Lakshmanan , Arvindbharani Rajansowri , Vivek JanarathanamManivannan
Published: November 2021

Eichhornia crassipes (Water hyacinth) is considered as a hazardous weed in numerous places of the world. Despite of its harmful effects, the weed offers potential substrate for production of monetarily industrial important and value added products. In the present study, an eco-friendly bioconversion or biotransformation of processed water hyacinth biomass (WHB) into high efficiency fuel, adsorbent for brewery industry waste water treatment coupled methylene blue dye, biofertilizer and nutrient media for viable inoculam production of fungal biopesticide Nomuraea rileyi was carried out adopting green science in situ principles. Bioconversion of the WHB was initiated by alkali treatment which brought about notable differences in physical texture and chemical composition. Pre-treated WHB was enzymatically hydrolysed into soluble simple sugars followed by fermentation of the sugar into ethanol with 65.2 % total yield with 77.3 g/l final concentration. Batch studies reveals that WHB brought about effective reduction of various physicio chemical properties and notable adsorption efficacy. Plant growth promoting effect was studied using green gram (Vigna mungo). Green gram grew on soil under pot culture technique inoculated with WHB uncovers imperative plant growth promotion effect. Culture medium prepared from reconstituted WHB supported viable inoculum production of potential fungal biopesticide Beauveria bassiana. Fungal inoculum derived from the WHB based culture medium was effective against larval instars of castor semi-looper Achaea janata in terms of high mortality.The present examination uncovers the conceivable viable bioconversion of water hyacinth biomass (WHB) into different worth included vitality, ecological as gives a green procedure to cleaner production and the executives of aquatic invasive weeds.
Relationship Between the Visual Evoked Potential and Structure in the Primary Visual Cortex in Healthy Individuals and in Patients with Severe Mental Disorders
Authors: Slapø Nora Berz , Jørgensen Kjetil , Elvsåshagen Torbjørn , Nerland Stener , Roelfs Daniel , Valstad Mathias , Timpe Clara , Richard Genevieve , Beck Dani , Sæther Linn Sofie , Werner Maren , Lagerberg Trine , Andreassen Ole , Melle Ingrid , Agartz Ingrid , Westlye Lars T. , Moberget Torgeir , Jönsson Erik G.
Published: November 2021

Schizophrenia (SCZ) spectrum and bipolar disorder (BD) are severe mental disorders with unknown pathophysiology. Altered visual evoked potential (VEP), an electroencephalogram signal reflecting function in the primary visual cortex (V1), abnormal visual processing and visual hallucinations reported in these patients, all point towards V1 dysfunction. While the mechanisms contributing to V1 dysfunction remain unknown, structural alterations are possible candidates. Lack of insight into neural substrates of structure and functional in V1 has limited our ability to determine implications of altered V1 function. While combining VEP and magnetic resonance imaging has increased our understanding of the structure-function relationship in V1 in healthy individuals, no previous study has examined the same structure-function relationship in patients with SCZ spectrum and BD. Here, we aimed to confirm previous findings of a selective positive correlation between the amplitude of the P100 component of the VEP and V1 surface area (SA) in 307 healthy individuals and to examine whether this relationship was altered in patients with SCZ spectrum (n=30) and BD (n=45). The correlation between the P100 amplitude and the total, (r=0.16, p=0.006), right (r=0.14, p=0.013) and left V1 surface area (r=0.13, p=0.02) was significant in healthy individuals, but not in patients. The current results support previous findings of a selective relationship between P100 amplitude and V1 surface area in healthy individuals and suggests that other factors than V1 surface area or thickness explain V1 dysfunction reported in these patients.
Extracto de Acacia farnesiana para el control de larva de Aedes aegypti
Authors: Granados Montelongo Juan Antonio , Núñez Colima Juan Antonio , Trujillo Zacarías Issanelly , Cano del Toro Jesús , Chan-Chablefirma Rahuel J. , Hidalgo de León Aimir
Published: November 2021

Introducción: Aedes aegypti es el principal vector de dengue, chikunguña, fiebre amarilla y zika en el mundo; el control químico es el más utilizado para su prevención, atacando la reproducción del mosquito vector, principalmente mediante la aplicación de insecticidas sintéticos en sus lugares de cría. Sin embargo, el uso de insecticidas sintéticos ha generado resistencia en los mosquitos y diversos problemas ecológicos. Los extractos naturales de plantas con función insecticida son utilizados como alternativa para el control de vectores. El objetivo del presente estudio fue evaluar la actividad larvicida del extracto de vaina de Acacia farnesiana contra larvas de cuarto estadio de Ae. aegypti.
Método: el estudio fue desarrollado en el Laboratorio del Instituto Tecnológico Superior de San Pedro, Coahuila, y en el ejido Mayran, San Pedro, Coahuila, México. Para la elaboración del extracto se utilizó la metodología propuesta por INIFAP-CENID-RASPA 1997. Los productos extractados se utilizaron en los bioensayos con larvas de cuarto estadio de Ae. aegypti durante 168 horas. Se transfirieron grupos de 20 larvas en vasos plásticos con 50 mL de agua, luego se aplicó 1 mL de cada uno de los tratamientos de fruto de Acacia farnesiana con concentraciones finales de 15 % (T1), 25 % (T2), 35 % (T3) y 70 % (T4). Para el control químico se utilizó Abate® 1SG (Temefos) al 25 %. Al testigo no se aplicó ningún tratamiento. Para comparar la mortalidad se realizó un análisis de varianza de un factor para cada uno de los estudios (laboratorio y campo) y un análisis de medidas repetidas en el tiempo para la fase de campo. Se desarrolló una prueba de comparación de medias de Tukey. Los análisis se realizaron usando el programa computacional estadístico IBM.SPSS 18, con un nivel de significancia de P ≤ 0.05.
Resultados: en el laboratorio, el extracto de A. farnesiana al 35 % de concentración mostró mayor toxicidad contra las larvas de Ae. aegypti obteniendo una mortalidad media de 15.66 (78.3 %),  transcurridas las 72 horas después de la aplicación del tratamiento (P ≤ 0.05). De igual forma, en condiciones de campo, el tratamiento al 35 % resultó ser el más efectivo, alcanzando una media de 19.04 (95.2 %) larvas muertas.
Discusión o Conclusión: el extracto de A. farnesiana mostró actividad insecticida contra larvas de Ae. aegypti, siendo más efectivo a una concentración de 35 % en condiciones de laboratorio y campo. El efecto larvicida del extracto de A. farnesiana puede ser utilizado como una alternativa factible y sustentable para el control Ae. aegypti en zonas rurales. Sin embargo, es necesario realizar más estudios para identificar los ingredientes activos y el mecanismo de acción presente en las vainas de A. farnesiana para el control de vectores.
Modeling of the dynamics of tornado structures in a pipe with turbulators of square, semicircular and triangular profiles
Authors: Lobanov I. E.
Published: November 2021

Objectives. To carry out mathematical simulations of changes in time of tornado compositions in channels with projections of semicircular, triangular, square profiles for average Reynolds criteria based on multiblock computing technology with the solution of finite- volume factorized methods of the Reynolds equation and energy equations.

Method. The calculations were carried out on the basis of theoretical approaches based on the solution of Reynolds equations by finite-volume factorized methods, which were closed using the simulation of Menter stresses, and the energy of a structured grid.

Result. The calculations of time-dependent flow and heat transfer parameters carried out in the article showed that the excess dissipation of turbulence generation for projections of sharp profiles - square profile, triangular profile - and rounded profiles - semicircular profile, segment profile - is provided with radically different hydraulic losses: channels with protrusions of rounded profiles, for example, semicircular, have much lower hydraulic resistance coefficients than channels with protrusions with sharp profiles, for example, triangular or square, rectangular.

Conclusion. In the article, mathematical simulations of time-dependent tornado compositions were performed in channels with transversal profiles in the form of a square, triangle and semicircle, which is as informative as possible in terms of studying turbulent flows and heat transfer arising under average Reynolds criteria based on computer multiblock technology when using solutions of finite-volume factorized methods (FCOM-am) Reynolds equations and energy equations. The following protrusions were considered in the article: square transversal profiles, in which tornadoes are most pronounced, and side tornadoes affect the flow in the maximum way; triangular transversal profiles, where tornadoes are not so strong, and side tornadoes affect the main flow weaker than with square protrusions; semicircular transversal profiles, in which the incoming main tornado moves along the stream with the generation of limited side tornadoes. The calculated information obtained in the article correlates to a high degree with the available experimental data, which indicates the verification of the mathematical modeling involved in the article.
Algorithm of fire detection for multi-sensor system
Authors: Bagutdinov R. A. , Stepanov M. F.
Published: November 2021

Objective. The paper proposes a fire detection algorithm for a multisensor system. Due to the difficult conditions in the field, for the first time, watch rescue operations are difficult and often endanger the lives of rescuers. The main scientific goal is for the system to work autonomously on certain segments of the monitoring process, while the three agents, to varying degrees, must interact with each other based on communication and decision-making algorithms.

Method. There are many algorithms for image processing, but algorithms that use several sources of information are not sufficiently developed and described. The focus is on fire detection algorithms. The algorithm was developed using NI Vision Assistant, a software tool for rapid prototyping and testing of imaging applications.

Result. In addition to the software implementation in C, which NI Vision Assistant generates by default, the paper presents a Python implementation of the algorithm.

Conclusion. The results of the work can be used to develop multisensor systems for monitoring hard-to-reach areas.
Electronic Health Record Implementations and Insufficient Training Endanger Nurses’ Well-being: Cross-sectional Survey Study
Authors: Heponiemi Tarja , Gluschkoff Kia , Vehko Tuulikki , Kaihlanen Anu-Marja , Saranto Kaija , Nissinen Sari , Nadav Janna , Kujala Sari
Published: November 2021

Background

High expectations have been set for the implementations of health information systems (HIS) in health care. However, nurses have been dissatisfied after implementations of HIS. In particular, poorly functioning electronic health records (EHRs) have been found to induce stress and cognitive workload. Moreover, the need to learn new systems may require considerable effort from nurses. Thus, EHR implementations may have an effect on the well-being of nurses.

Objective

This study aimed to examine the associations of EHR-to-EHR implementations and the sufficiency of related training with perceived stress related to information systems (SRIS), time pressure, and cognitive failures among registered nurses. Moreover, we examined the moderating effect of the employment sector (hospital, primary care, social services, and others) on these associations.

Methods

This study was a cross-sectional survey study of 3610 registered Finnish nurses in 2020. EHR implementation was measured by assessing whether the work unit of each respondent had implemented or will implement a new EHR (1) within the last 6 months, (2) within the last 12 months, (3) in the next 12 months, and (4) at no point within the last 12 months or in the forthcoming 12 months. The associations were examined using analyses of covariance adjusted for age, gender, and employment sector.

Results

The highest levels of SRIS (adjusted mean 4.07, SE 0.05) and time pressure (adjusted mean 4.55, SE 0.06) were observed among those who had experienced an EHR implementation within the last 6 months. The lowest levels of SRIS (adjusted mean 3.26, SE 0.04), time pressure (adjusted mean 4.41, SE 0.05), and cognitive failures (adjusted mean 1.84, SE 0.02) were observed among those who did not experience any completed or forthcoming implementations within 12 months. Nurses who perceived that they had received sufficient implementation-related training experienced less SRIS (F1=153.40, P<.001), time pressure (F1=80.95, P<.001), and cognitive failures (F1=34.96, P<.001) than those who had received insufficient training. Recent implementations and insufficient training were especially strongly associated with high levels of SRIS in hospitals.

Conclusions

EHR implementations and insufficient training related to these implementations may endanger the well-being of nurses and even lead to errors. Thus, it is extremely important for organizations to offer comprehensive training before, during, and after implementations. Moreover, easy-to-use systems that allow transition periods, a re-engineering approach, and user involvement may be beneficial to nurses in the implementation process. Training and other improvements would be especially important in hospitals.
Effects of Prosthetic Rehabilitation on Temporomandibular Disorders: Protocol for a Randomized Controlled Trial
Authors: Sreekumar Saranya , Janakiram Chandrashekar , Mathew Anil
Published: November 2021

Background

Loss of teeth or occlusal imbalance is one of the proposed dental risk factors for temporomandibular disorders (TMDs). Losing some non–free-end teeth cause the original occluding tooth/teeth to supraerupt from the original upright position and causes neighboring tooth/teeth to shift in an angle, causing biomechanical imbalance on the mandible. Based on these sequelae, rehabilitation of missing teeth is the first step in managing TMD in edentulous patients. Even though the prevalence of TMD in association with edentulism and in rehabilitated patients has been increasing, proper guidelines for the management of such cases have not been established. This study describes the protocol to analyze the effect of prosthetic rehabilitation on patients with TMD.

Objective

This study aims to determine the effectiveness of prosthetic rehabilitation in the reduction of pain in edentulous patients with TMD and to determine the effect of the span of edentulism, the number of quadrants involved, pathological migration, the type of Kennedy classification, and the prosthetic status on temporomandibular joint dysfunction signs and symptoms.

Methods

In this randomized controlled trial, 300 patients diagnosed with TMD will be grouped into one of the three interventional groups based on the type of their edentulous state. The interventional groups are (1) partially edentulous arch: Kennedy Class I and II (prosthetic rehabilitation without splint); (2) partially edentulous arch: Kennedy Class III and IV (prosthetic rehabilitation with a splint); and (3) completely edentulous arches (prosthetic rehabilitation without splint). All three of the mentioned interventional groups have corresponding control groups that will receive symptomatic treatment and comprehensive counseling. The measured primary outcomes are pain and electromyogram, and the secondary outcomes include pain drawing, Graded Chronic Pain Scale, Jaw Functional Limitation Scale, Oral Behaviours Checklist, depression, physical symptoms, and anxiety. The outcome measurements will be recorded at baseline and at the end of 24 hours, 7 days, 28 days, and 3 months.

Results

Ethical approval was obtained from the Institutional Review Board of Amrita Institute of Medical Sciences, Kochi, India. Study participants’ recruitment began in May 2021 and is expected to conclude in March 2023. This clinical trial protocol was developed based on the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Statement.

Conclusions

The purpose of this study is to gather data on prosthetic rehabilitation as a treatment for TMD. Obtaining this goal will aid in the development of evidence-based therapy protocols for prosthetic rehabilitation in TMD management.

Trial Registration

Clinical Trials Registry - India CTRI/2020/06/026169; http://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=42381

International Registered Report Identifier (IRRID)

DERR1-10.2196/33104
Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2 (Preprint)
Authors: Liu Sr Yanyan , Liu xiaomei , Yuan xiuying , Feng poling , Ouyang zhiwei , Ouyang zhiwei , Li cuifen
Published: November 2021

BACKGROUND

Long non-coding RNA tumor protein 53 target gene 1 (TP53TG1) has been studied in multiple diseases, while the regulatory function of TP53TG1 on cervical cancer (CC) via regulating microRNA (miR)-33a-5p to target Forkhead box K2 (FOXK2) remains limited. This study aims to unearth the effects of TP53TG1/miR-33a-5p/FOXK2 axis on CC.

OBJECTIVE

This study aims to unearth the effects of TP53TG1/miR-33a-5p/FOXK2 axis on CC.

METHODS

The clinical samples were collected and TP53TG1, miR-33a-5p and FOXK2 levels were examined in CC tissues. The CC cells were transfected with high- or low-expressed TP53TG1, FOXK2 and miR-33a-5p to determine the change of CC cell biological activities and the status of phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway. The tumorigenesis in nude mice was conducted. The relationship among TP53TG1, miR-33a-5p and FOXK2 was validated.

RESULTS

TP53TG1 and FOXK2 were enriched and miR-33a-5p was inhibited in CC. The reduced TP53TG1 or FOXK2 or elevated miR-33a-5p decelerated the CC cell development and the activation of PI3K/AKT/mTOR signaling pathway. The depleted FOXK2 or enriched miR-33a-5p reversed the effects of decreased TP53TG1. TP53TG1 sponged miR-33a-5p which targeted FOXK2. The experiment in vivo validated the outcomes of the experiment in vitro.

CONCLUSIONS

TP53TG1 accelerates the CC development via regulating miR-33a-5p to target FOXK2 with the involvement of PI3K/AKT/mTOR signaling pathway. This study provides novel theory references and a distinct direction for the therapy strategies of CC.
Secret of Instructional Design Revisited
Authors: Berge, Ph.D. Zane L.
Published: November 2021

Improvements in technology, especially automation, robotics, and artificial intelligence have dramatically changed what people do in the workplace and how they do it. Technology advancements over the past 3 decades have reshaped demands in schooling and the workplace bringing on new challenges and opportunities. Employers need employees who are critical thinkers, communicators, collaborators, and creators to remain competitive and innovative. Educators recognize these abilities that learners must have to take advantage of the opportunities and face the challenges that are presented to them in the 21st century. As was the case 30 years ago, the same consistency is needed today among the four elements of instructional design: objectives, methods, content, and evaluation. There must also be integration of the instructional system with authentic, real-world performance. If these two critical aspects are not met the chances of obtaining the desired effectiveness of learning is not likely to be met. The Internet and cloud computing allow more rapid development of instruction for more efficient and affective learning. The pace of change also requires a greater emphasis on the iterative nature of evaluating the instructional design system.
Role of a Strategic Management Team in Conflict Resolution: A Case Study of IKEA
Authors: Parbat Tanmayee
Published: November 2021

Abstract: The thesis looked into and investigated the topic at hand as a case study of IKEA's strategic management team in dispute resolution. Organizational operations changes have a cascade effect on marketing and human resource management, undermining efforts at standardization and localization. Workplace disagreement can jeopardise organizational goals, leading to dysfunction and excessive competition. Workplace conflict must be addressed before it has a detrimental impact on team productivity and leads businesses to lose money. However, workplace disagreements can lead to the formation of positive relationships, peer learning, enhanced communication, new ideas, and increased motivation. We used transformational leadership theory to look at how senior account managers deal with conflict at work for this study. The thesis looked at IKEA's marketing techniques for forming a strategic management team to handle conflicts, and it was based on extensive research and accurate data.
Analysing the Role of Macro Environment Analysis in Business Success of Ford
Authors: Jain Honey
Published: November 2021

Abstract: Managers frequently use strategic analysis to help them make decisions. It's necessary for developing strategic plans because it considers both the company's internal and external settings. The company's situation is examined in light of a variety of market conditions as well as potential dangers. Additionally, the business's strong and weak points are evaluated and either improved or eliminated. Today's market-leading businesses are founded on a sound strategic analytic foundation. Depending on the organization's focus on the external environment, industry, or internal environment, a variety of methodologies can be employed for strategic analysis. Strategic planning Ford's purpose with this initiative is to create the theoretical foundation for strategic analysis by emphasising the importance, meaning, and technique of marketing environment research.
Persistent Cohesion with Advanced Ring Signatures for Shared Data in Cloud
Authors: Begum M. Shaheda
Published: November 2021

Abstract: Motivated by the exponential growth and the huge success of cloud data services bring the cloud common place for data to be not only stored in the cloud, but also shared across multiple users. Our scheme also has the added feature of access control in which only valid users are able to decrypt the stored information. Unfortunately, the integrity of cloud data is subject to skepticism due to the existence of hardware/software failures and human errors. Several mechanisms have been designed to allow both data owners and public verifiers to efficiently audit cloud data integrity without retrieving the entire data from the cloud server. However, public auditing on the integrity of shared data with these existing mechanisms will inevitably reveal confidential information—identity privacy—to public verifiers. In this paper, we propose a novel privacy-preserving mechanism that supports public auditing on shared data stored in the cloud. In particular, we exploit ring signatures to compute verification metadata needed to audit the correctness of shared data. With our mechanism, the identity of the signer on each block in shared data is kept private from public verifiers, who are able to efficiently verify shared data integrity without retrieving the entire file. In addition, our mechanism is able to perform multiple auditing tasks simultaneously instead of verifying them one by one. Our experimental results demonstrate the effectiveness and efficiency of our mechanism when auditing shared data integrity. Keywords: Public auditing, privacy-preserving, shared data, cloud computing
Topology Optimization of Vehicle B-Pillar
Authors: Metar Manas
Published: November 2021

Abstract: Weight reduction techniques have been practiced by automobile manufacturers for the purpose of long range, less fuel consumption and achieving higher speeds. Due to the numerous set objectives that must be met, especially with respect to of car safety, automotive chassis design for vehicle weight reduction is a difficult task. In passenger classed vehicles using a monocoque chassis for vehicle construction has been a great solution for reducing overall wight of the vehicle body yet the structure is more stiffened and sturdier. However, some parts such as A-pillar, B-pillar, roof structure, floor pan can be further optimized to reduce more weight without affecting the strength needed for respective purposes. In this paper, the main focus is on reducing weight of the B-pillar. The B-pillar of a passenger car has been optimized using topology optimization and optimum weight reduction has been done. The modelling and simulation are done using SOLIDWORKS 3D software. The B-pillar in this study has been subjected to a static load of 140 KN. Further by providing goals and constraints the optimization was caried out. The results of Finite Element Analysis (FEA) of the original model are explained. The Topology Optimization resulted in reducing 53% of the original weight of the B-pillar. Keywords: Structural optimization techniques, weight reduction techniques, weight reduction technologies, need for weight reduction, Topology optimization, B-pillar design, structural optimization of B-pillar, Topology optimization of B-pillar.
Artistic Image Depiction Elements in the Works of Edgar Allan Poe
Authors: Takhmina Akramova
Published: November 2021

Abstract: The article examines the elements of the representation of the artistic image in a literary work, individual speech features, phonetic devices, morphological categories and expressions of the character's speech. The literary device of stanzas of Edgar Allan's works is analyzed and examined, the semantic features of the features of images and all kinds of reproduced linguistic means are traced. Keywords: reproducible linguistic means, element of artistic image, phonetic devices, individuality, expressiveness, versatility, vivid and expressive meaning, disgusting abomination, deep feeling of loneliness, personification, inanimate objects, human qualities.
Alianza de necesidad y urgencia. Las políticas de comunicación en la prensa argentina (diciembre 2015-enero 2016)
Authors: Califano Bernadette , Koziner Nadia Sabrina
Published: November 2021

Este artículo analiza el tratamiento que realizó la prensa argentina de la política de comunicación del gobierno de Mauricio Macri (2015-2019) a lo largo de los dos primeros meses de su gestión. El trabajo procura: a) identificar la relevancia que cobró este asunto en los diarios Ámbito Financiero, Clarín, El Cronista Comercial  y Página/12; b) caracterizar los tópicos principales de las coberturas mediáticas; y c) examinar comparativamente los modos en que los medios valoraron las medidas implementadas. La investigación se apoya conceptualmente en los estudios de políticas de comunicación filiados en la economía política crítica y en el análisis de contenido de las coberturas periodísticas, y recurre a la técnica de análisis de contenido cuantitativo. Se concluye que la prensa otorgó gran relevancia a la política de comunicación del Gobierno. Empero, se hallaron diferencias pronunciadas con relación a los tópicos que organizaron las coberturas y a la valoración de la política pública, la que exhibió rasgos de polarización.
Methodological Approach and Technological Framework to Produce a Massive Open Online Course (MOOC) in Biodegradable Packing
Authors: Guzman Ordoñez Anabel , León Casanova Carlos , Villada Castillo Héctor Samuel , Palechor Tróchez Jhon Jairo , León Roa Carlos
Published: November 2021

This article shows the different stages used for the design and production of a MOOC for biodegradable packing, the planning tools and methodologies used for the development of the themes and contents. Likewise, is shown the technological framework used making a surveillance technology to identify which stage the MOOC e-learning tech is and the search of terms related to biodegradable packing to identify potential topics. Finally, the software architecture for SELENE is explained and how is deployed in open edX platform.
Beneficial effects of pyruvate for a high-density perfusion process
Authors: Caso Stefania , Aeby Mathieu , Jordan Martin , Guillot Raphael , Bielser Jean-Marc
Published: November 2021

High volumetric productivities can be achieved when perfusion processes
are operated at high cell densities. Yet it is fairly challenging to
keep high cell density cultures in a steady state over an extended
period. Aiming for robust processes, in this study cultures were
operated at a constant biomass specific perfusion rate (BSPR). The cell
density was monitored with a capacitance probe and a continuous bleed
maintained the cell density at the targeted viable cell volume (VCV).
Despite our tightly controlled BSPR, a gradual accumulation of ammonium
and changes in cell diameter were observed during the production phase
for the three different monoclonal antibodies (mAbs). Although a lot of
efforts in media optimization have been made to reduce ammonium in
fed-batch process, less examples are known about how media components
impact the cellular metabolism and thus the quality of monoclonal
antibodies in continuous processes. In this work, we show that a
continuous Na-pyruvate fed at 2 g/L/day strongly reduced ammonium
production and stabilized fucosylation, sialylation and high mannose
content for three different mAbs.
TAFRO syndrome: a case report
Authors: Meng Shan , Liu Hailing , Zhang Wang-Gang , He Aili , Sun Honghong , Zhang Ru , Chen Xiaoli , Chen Yinxia
Published: November 2021

A man diagnosed as TAFRO syndrome was successfully responded to a novel
immunosuppressive regimen containing methylprednisolone and
mycophenolate mofetil. Blood cells firstly recovered, followed by the
general situation and complete recover 1 month later, highlighting the
danger of TAFRO syndrome and the importance of immunosuppressive agents
in reversing pathological course
Dementia as a core clinical feature of a patient with aceruloplasminemia
Authors: Ashrafi Farzad , Salari Mehri , Nouri Fatemeh , shiravi fatemeh
Published: November 2021

Aceruloplasminemia is an autosomal recessive disease, caused by systemic
iron accumulation due to mutations in the Ceruloplasmin gene. We report
two Iranian siblings who have diagnosed with aceruloplasminemia. Based
on our researches, dementia hasn’t been published as the first
neurological feature while one of them was presented with pure dementia
Capturing Surface Complementarity in Proteins using Unsupervised Learning and Robust Curvature Measure
Authors: Gupta Abhijit , Mukherjee Arnab
Published: November 2021

The structure of a protein plays a pivotal role in determining its
function. Often, the protein surface’s shape and curvature dictate its
nature of interaction with other proteins and biomolecules. However,
marked by corrugations and roughness, a protein’s surface representation
poses significant challenges for its curvature-based characterization.
In the present study, we employ unsupervised machine learning to segment
the protein surface into patches. To measure the surface curvature of a
patch, we present an algebraic sphere fitting method that is fast,
accurate, and robust. Moreover, we use local curvatures to show the
existence of “shape complementarity” in protein-protein,
antigen-antibody, and protein-ligand interfaces. We believe that the
current approach could help understand the relationship between protein
structure and its biological function and can be used to find binding
partners of a given protein.
The Information Content of Publicly Accessible Federal Court Documents
Authors: Carrizosa Richard D. , Cazier Richard A.
Published: November 2021

Prior research documents a negative stock price reaction to initial securities lawsuit filings, on average. Prior research provides no evidence, however, regarding whether and how the market prices information subsequently generated by the litigation process. We examine the market response to a large sample of initial plaintiff complaints and subsequent docket events. Our results are consistent with the market pricing information about issues both systemic to the firm and specific to the pending lawsuit from federal court filings. First, we find the market response to the initial lawsuit filing varies significantly with information about governance and control problems signaled by details of the plaintiff's complaint. Second, we find a significant market response to subsequent court filings that increases with measures of litigation severity and decreases as the litigation progresses over time. Overall, our results highlight the role of federally accessible court filings in facilitating the market's pricing of defendant firms.

JEL Classifications: K41; M40; M41; M48.
Vida plena apesar da doença:
Authors: Silva Wallace de Gois
Published: November 2021

A teologia é um saber interdisciplinar, que envolve questões da profundidade da existência. A partir de citações poéticas Rubem Alves, Adélia Prado e Clarice Lispector emprestam importante sentido existencial, literário, vivencial à reflexão pela integridade. No Primeiro e no Segundo Testamentos, saúde é shalom: inteireza, paz, bem-estar. É plenitude de vida diante de Deus e das pessoas. Esse testemunho ilumina noções teológicas como a que propõe Paul Tillich sobre saúde, cura e doença, isto é, uma perspectiva da integração do ser humano a si mesmo e ao todo, para superar a alienação existencial e a angústia patológica, objetivo que pode ser alcançado por meio da cooperação entre as especialidades médicas e psi e o ministério religioso, que atuam em conjunto com o divino na superação das ambiguidades e da finitude que ameaçam o ser. Nesse sentido, a comunidade religiosa é pensada como ambiente terapêutico, que acolhe a pessoa, restaura-lhe a integridade e promove o encontro com a Presença Espiritual – a mesma que fortalece o indivíduo a tornar-se novo-ser – e a experimentar a vida no Espírito, que integra todas as dimensões e as cura, ainda que diante das doenças, da finitude, da consciência da morte.
Filosofia da Religião em Abraham Joshua Heschel:
Authors: Guerra Danilo Dourado , Nogueira Emivaldo Silva
Published: November 2021

Nesse texto, na tentativa de compreensão do conceito metodológico de autodiscernimento encontrado na filosofia proposta por Abraham Joshua Heschel, objetivamos atentar para a sua compreensão do conceito de “Homem”, uma vez que o autodiscernimento pressupõe o homem que procura a sua essência transcendental. E mais ainda, para Heschel, a filosofia tem a função de analisar a religião como responsável pelas respostas fundamentais do homem, quando a religião deixa de fazer isso, ou ela se tornou ineficaz ou o homem moderno se tornou animalizado, indiscernido. Estrutura-se, pois, o fenômeno do Eclipse de Deus na modernidade. Inventariar tais matizes filosóficos à luz de Abraham Joshua Heschel torna-se o desafio por nós proposto na senda sequencial deste artigo.
diabo e a tentação em “O Moinho do Diabo”, de Andersen
Authors: Meira Vanessa
Published: November 2021

Este artigo fará, através da pesquisa bibliográfica, uma avaliação teológica do conto “O Moinho do Diabo”, de Hans Christian Andersen. Essa análise incluirá o cotejamento entre a narrativa de Andersen e outras narrativas que incluam as figuras do diabo como tentador e do moinho como lugar de tentação. Através dessa pesquisa, é possível concluir um dos objetivos desse conto é garantir ao fiel que, ainda que o diabo seja astuto, é possível superá-lo, e até mesmo enganá-lo, como demonstrou Andersen.
Nabo Vermelho:
Authors: Tobias Vinicius
Published: November 2021

O haicai japonês é uma forma poética que tem como temática principal a experiência com as coisas. O apontar das coisas no haicai está relacionado ao contexto zen em que teve origem, sendo uma representação da experiência de satori, iluminação súbita.  Roland Barthes sistematiza no haicai três importantes operações semióticas: isso foi, é isso! e o apenas isso. Cada uma dessas operações apontam as coisas, sendo a primeira uma operação de autoridade, a segunda de insight e a terceira de naturalidade. Este artigo, parte dessas reflexões em torno do haicai em busca de termos que permitam abordar poemas que expressam experiência religiosa que se dão no contato com as coisas, no que proponho chamar de mística literária das coisas. Uma expressão que pretende reunir impulsos religiosos dentro da literatura que tenham semelhanças eletivas com aquilo que é expresso no haicai e que tenha autoridade, insight e que busque naturalidade nas coisas.
Grupo de pesquisa REPLUDI/PUC Minas e sua linha de pesquisa Religião, Linguagem e Literatura
Authors: Cantarela Antonio Geraldo , Jordão Tânia Dias , Naves Alair Matilde
Published: November 2021

Este artigo apresenta a linha de pesquisa Religião, Linguagem e Literatura, que integra o grupo de pesquisa Religião, Pluralismo e Diálogo (REPLUDI), ligado ao Programa de Pós-graduação em Ciências da Religião da PUC Minas. O texto descreve algumas atividades do grupo, em seu conjunto, e, mais particularmente, a produção acadêmica da linha, bem como as referências teóricas e metodológicas que sustentam suas pesquisas. O objetivo principal deste relato, repercutindo o que a revista Teoliterária tem realizado em seus 10 anos de existência, associa-se ao interesse de compartilhar nossas pesquisas com outros pesquisadores e grupos que debatem as interfaces entre teologia/ciências da religião e literatura. Os dados históricos e bibliométricos aqui apresentados foram buscados no site do PPGCR, nas redes sociais do grupo de pesquisa e na plataforma lattes. As questões teóricas e metodológicas foram extraídas das produções acadêmicas dos pesquisadores.
ANALISIS FOREIGN BRANDING, HARGA DAN KUALITAS PRODUK DALAM KEPUTUSAN PEMBELIAN
Authors: Hasanah Sarah Uswatun , Wulandari Jeni , Subagja Ghia
Published: November 2021

This study examines purchasing decisions of The Executive product, viewed from the aspect of foreig branding, price, and product quality in the perspective of consumer behavior. A quantitative approach was applied, using a questionnaire to 400 respondents. The sampling technique using purposive sampling. Data were analyzed using multiple linear regression analysis. The results of the study indicated that foreign branding, price, and product quality influence purchasing decisions partially and simultaneously had positive and significant effect on purchasing decision. The highest effect in this study was product quality, with comfort and quality of raw material which the main factor need to be maintened because they determined the purchasing decision of The Executive as a fashion product.

Abstrak

Studi ini mengkaji keputusan pembelian produk The Executive, dilihat dari aspek foreign branding, harga, dan kualitas produk dalam perspektif perilaku konsumen. Pendekatan kuantitatif diterapkan, dengan menggunakan kuesioner pada 400 responden. Teknik pengambilan sampel menggunakan purposive sampling. Data dianalisis menggunakan analisis deskriptif dan regresi linear berganda. Hasil studi menunjukkan bahwa secara parsial dan simultan, foreign branding, harga, dan kualitas produk berpengaruh terhadap keputusan pembelian. Pengaruh terbesar terletak pada variabel kualitas produk, dengan kenyamanan dan kualitas bahan baku menjadi faktor dominan yang perlu dipertahankan, karena menentukan keputusan pembelian The Executive sebagai produk fashion.
Seismic assessment of tall RC frames with hybrid friction damper and SMA designed by PBPD method
Authors: Norouzi F. , Nasebaradi H. , Jamshidi M.
Published: November 2021

In this study, a new lateral load resisting system for high-rise (Reinforced Concrete) RC frames is proposed, which includes friction damper-superelastic SMA wires. The proposed SMA-friction damper can not only regulate the mechanism of frictional energy dissipation components with its self-centering SMA wires according to the design method based on the proposed performance, which is able to provide a hysteretic behavior and high self-centering capacity with the lowest SMA consumption but also has some advantages such as simple configuration and economic application. In this paper, two high-rise 18 and 22-story RC frames were designed in two design modes of common and with the proposed damper. The nonlinear time history analysis subjected to 10 far-field earthquakes performed in Opensees software. The results of the analyses showed that using the proposed SMA-friction damper, in addition to the effective increase in ductility, lateral stiffness and lateral strength, provided an excellent self-centering capacity, which resulted to the significant reduction in the maximum drift and the residual deformations in the structure.
Application of discretization error estimators in stepped column buckling problems
Authors: Souza B. , Fernades D. , Anflor C. , Morais M.
Published: November 2021

In order to reduce the discretization error, in this paper, Richardson’s Extrapolation and Convergence Error Estimator were used to investigating the buckling problem convergence. The main objective was to verify the convergence order of the stepped column problem and to define a consistent moment of inertia at the point of variation of the cross-section. The variable of interest was the critical buckling load obtained by the Finite Difference Method. The convergent solution obtained errors less than 10-8, and this work showed that the best solution is not defined by excessive mesh refinement, but by the solution convergence analysis.
Ocena wpływu nawozów azotowych na skład chemiczny ziarna pszenżyta jarego
Authors: BIEL WIOLETTA , JAROSZEWSKA ANNA
Published: November 2021

Celem badań było porównanie działania dwóch nawozów azotowych: azotu amonowego i Sulfammo 30 N Pro oraz dawki azotu na skład chemiczny ziarna pszenżyta jarego odmiany ‘Nagano’. Eksperyment przeprowadzono w latach 2013–2014 w Rolniczej Stacji Doświadczalnej w Lipniku, w województwie zachodniopomorskim (53º42'N, 14º97'S). W ziarnie pszenżyta jarego oznaczono zawartość: suchej masy, białka ogółem, tłuszczu surowego, włókna surowego, popiołu surowego i związków bezazotowych wyciągowych oraz frakcji włókna (NDF, ADF, ADL, HCEL, CEL). Zastosowanie nawożenia azotem w największej dawce (120 kg N·ha-1) wpłynęło istotnie na zwiększenie zawartości białka ogółem w ziarnie pszenżyta jarego (o 27% w stosunku do obiektu kontrolnego). Podwyższenie poziomu nawożenia azotem spowodowało istotne zmniejszenie poziomu BAW w ziarnie. Zwiększone nawożenie azotem miało istotny wpływ na wzrost zawartości ligniny. Rodzaj nawożenia spowodował zmiany zawartości suchej masy, tłuszczu surowego, włókna surowego oraz BAW w ziarnie pszenżyta jarego. Współdziałanie rodzaju nawozu i zastosowanych w doświadczeniu zróżnicowanych poziomów nawożenia azotem istotnie modyfikowało zawartość włókna surowego, frakcji neutralno-detergentowej włókna pokarmowego oraz hemicelulozy w badanym ziarnie pszenżyta jarego.