bluuebunny/crossref_metadata_2025 huggingface dataset:
STARGATE-X: a Python package for statistical analysis on the REACTOME network
Authors: Marino Andrea , Sinaimeri Blerina , Tronci Enrico , Calamoneri Tiziana
Published: September 2023

Many important aspects of biological knowledge at the molecular level can be represented bypathways. Through their analysis, we gain mechanistic insights and interpret lists of interesting genes from experiments (usually omics and functional genomic experiments). As a result, pathways play a central role in the development of bioinformatics methods and tools for computing predictions from known molecular-level mechanisms. Qualitative as well as quantitative knowledge about pathways can be effectively represented throughbiochemical networkslinking thebiochemical reactionsand the compounds (e.g., proteins) occurring in the considered pathways. So, repositories providing biochemical networks for known pathways play a central role in bioinformatics and insystems biology. Here we focus on Reactome, a free, comprehensive, and widely used repository for biochemical networks and pathways. In this paper, we: (1) introduce a tool StARGate-X (STatistical Analysis of theReactomemulti-GrAph ThroughnEtworkX) to carry out an automated analysis of the connectivity properties of Reactomebiochemical reaction network and of its biological hierarchy (i.e., cell compartments, namely, the closed parts within the cytosol, usually surrounded by a membrane); the code is freely available athttps://github.com/marinoandrea/stargate-x; (2) show the effectiveness of our tool by providing an analysis of the Reactomenetwork, in terms of centrality measures, with respect to in- and out-degree. As an example of usage of StARGate-X, we provide a detailed automated analysis of the Reactomenetwork, in terms of centrality measures. We focus both on the subgraphs induced by single compartments and on the graph whose nodes are the strongly connected components. To the best of our knowledge, this is the first freely available tool that enables automatic analysis of the large biochemical network within Reactomethrough easy-to-use APIs (Application Programming Interfaces).
CMOR motion planning and accuracy control for heavy-duty robots
Authors: Zuo Congju , Wang Weihua , Xia Liang , Wang Feng , Zhou Pucheng , Lu Leiji
Published: September 2023

Factors like rising work costs and the imminent transformation and upgrading of manufacturing industries are driving the rapid development of the industrial robotics market. In this study, by analyzing the structure of the transport arm and China Fusion Engineering Test Reactor and performing mathematical modeling, a feasible solution for the robot can be obtained using the dynamic ant colony optimization algorithm and grayscale values. However, for multiple degree of freedom robots, due to a large number of joints, the pure use of joint angle restrictions cannot avoid their own mutual interference. The design of the transport arm robot’s own collision algorithm is shown, which focuses on each linkage as a rod wrapped by a cylinder. The experiment shows that the relationship between the integrated center of mass and the whole machine center of mass can get the action area of the whole machine center of mass of the robot, according to which the relationship between the radius of the catch circle and time of the projection area of the whole machine center of mass of the robot in the horizontal plane can be obtained. The maximum outer circle radius

r

com

=
267.977

mm

{r}_{\text{com}}=267.977\hspace{.25em}\text{mm}

, according to the stability criterion

r

ssa

>

r

con

{r}_{\text{ssa}}\gt {r}_{\text{con}}

, can be obtained, so the stability analysis of the gait switching process can be judged to be correct and effective.
The mTOR pathway in the antiphospholipid syndrome
Authors: Ji Lanlan , Zhang Zhuoli , Perl Andras
Published: September 2023

This perspective discussed the available evidence on the involvement of mTOR pathway in antiphospholipid syndrome (APS), from the aspects of endothelial cells, platelets, monocytes and anti-phospholipid antibodies (PLs), which may lead to future therapeutic applications of mTOR inhibition in APS.
Phenotypic characterisation of indigenous chicken in the central zone of Tanzania
Authors: Moto Edward , Rubanza Chrispinus D. K.
Published: September 2023

The study was conducted to assess the phenotypic diversity within the indigenous chicken population in Tanzania, the central zone, preciously Dodoma and Singida regions. Six districts from two regions were purposively selected based on their potential for chicken population. A total of 176 adult local chickens of both sexes were used to estimate the body weight, linear body measurements and visual assessments of phenotypic traits. The results indicated that the predominant comb type was single (90.9%) followed by pea comb (6.8%). The dominant plumage colour was a combination of different colours (66%), followed by black (14%). Yellow shank colour (59.1%) was dominant over other colours. The estimated overall mean values of body weight, body length, chest circumference, and shank length were 1.80 kg, 39.3, 31.3, and 8.8 cm, respectively. Males were significantly heavier than females (2.2 vs 1.3 kg; p < 0.05). The values of most linear body measurement traits were significantly different (p < 0.01). The chest circumference was not significantly different across the studied districts. The present finding suggests that indigenous chickens in the study area possess unique genetic potentials that would be used for further breeding programs for optimum utilisation of these genetic resources by the rural communities.
Preparation of VO2/graphene/SiC film by water vapor oxidation
Authors: Xu Wenwen , Zhao Shanguang , Li Liang , Fan Lele , Yuan Jian , Zhang Yumeng , Li Bing , Liu Zhongliang , Liu Qinzhuang
Published: September 2023

Vanadium dioxide (VO2) has attracted extensive attention due to the specific metal-insulator phase transition as well as the wide device applications. The practical performance of VO2-based device strongly depends on the quality of VO2, since the higher quality of VO2 film always shows much more pronounced phase transition behavior. Thus, the preparation of high quality VO2 film is essential and highly desirable. In this work, we have prepared high-quality VO2 film on SiC substrate by water vapor oxidation with graphene (G) buffer layer, which showed excellent phase transformation properties. Compared with the VO2/SiC sample without G buffer layer, the VO2/G/SiC films show the resistance changes up to four-orders of magnitude across the phase transition boundary and superior optoelectronic properties, which indicates the significant role of G layer in the film growth process. The current study not only provides an economical and feasible method for VO2/G/SiC thin film preparation with high quality, but also supply some clues for the application of G-based VO2 devices in the future.
The effect of a partnership franchising model on consumer satisfaction for a large German cooperative retail chain before and during the COVID-19 pandemic
Authors: Bachmann Severin , Reichel Richard , Wrede Matthias
Published: September 2023

Der vorliegende Artikel analysiert für einen der größten deutschen Einzelhändler anhand von Webrezensionen den Effekt eines Partnerschafts-Franchising-Modells auf die Verbraucherzufriedenheit und die Unterschiede dieser Effekte vor und während der COVID-19-Pandemie. Das Besondere am Franchise-Modell dieser Kette ist, dass sich der Franchisegeber finanziell an einem Partnerschaftsmodell beteiligt und die Franchisenehmer wiederrum erhebliche unternehmerische Freiheiten genießen. Das Ergebnis dieser Studie zeigt, dass Verbraucher mit Franchisenehmern wesentlich zufriedener sind als mit zentral geführten Geschäften. Die Zufriedenheit der Verbraucher ging zurück und der Vorsprung der Franchisenehmer nahm während der Pandemie ab.
Genossenschaften mit vorgetäuschter Mitgliederförderung (Fake-Genossenschaften)
Authors: Fiedler Mathias
Published: September 2023

Genossenschaften haben, anders als andere Rechtsformen, einen besonderen gesetzlich vorgegebenen Zweck – sie betreiben einen gemeinschaftlichen Geschäftsbetrieb, den die Mitglieder nutzen sollen. Dieser Zweck – nämlich die Nutzungsorientierung – ist der Kern der genossenschaftlichen Idee. Häufiger wird nun darüber berichtet, dass die Rechtsform der eingetragenen Genossenschaft missbraucht wird. Dabei geht es vorrangig um Steuersparmodelle1, sei es zur Einsparung von Gewerbe- oder Körperschaftssteuer2 oder der Erbschaftssteuer3. Genannt werden diese Genossenschaften meist „Familiengenossenschaften“, weil es darum geht, dass Familien ihr Vermögen (Immobilien / Unternehmen) in eine Genossenschaft einbringen. Diesen Begriff wollen wir nicht verwenden, weil es schon länger Familiengenossenschaften gibt, die vollkommen im Einklang mit dem Genossenschaftsgesetz agieren4, wir verwenden nachfolgend den Begriff „Fake-Genossenschaften“, weil sie die Voraussetzungen für eine Genossenschaft unseres Erachtens nicht erfüllen.
Les sociétés de développement local, une solution pour la gouvernance du secteur public : le cas de Casablanca, au Maroc
Authors: Dinaoui Mehdi , El Gnaoui Leila
Published: September 2023

La gouvernance fait référence à toutes les mesures et règles qui assurent le bon fonctionnement et le contrôle d’un État, d’une institution ou d’une organisation. Elle vise à rendre l’action publique plus efficace, plus proche des intérêts publics et généraux et, donc, plus légitime. Elle devrait rendre la société plus facile ou harmonieuse à gouverner. De ce fait, les sociétés de développement local (SDL) représentent un nouveau modèle de développement dans le but de dégager la performance publique. Elles sont constituées en sociétés anonymes, à l’initiative des collectivités locales, pour exercer des activités économiques relevant de la compétence de la commune. Ainsi, elles ont pour vocation l’amélioration de la gouvernance urbaine. L’objectif de cet article est de montrer le rôle des SDL dans la gouvernance du secteur public et dans le développement local à Casablanca, au Maroc.
Les mécanismes de gouvernance liés au financement par le capital-risque : une perspective théorique
Authors: Laachach Abderrahim , Ettahri Younes
Published: September 2023

La relation entre l’entrepreneur et l’investisseur est souvent abordée sous un cadre conflictuel basé sur l’asymétrie informationnelle et sur l’opportunisme potentiel des acteurs. Cependant, la pratique de financement par le capital-risque renferme des liens mitigés entre les capital-risqueurs et les entrepreneurs. Dans cette relation, les capital-risqueurs cherchent à orienter les projets financés vers des perspectives de réussite, tout en sécurisant leur fonds d’investissement par la négociation d’un ensemble de dispositions juridiques. De leur côté, les entrepreneurs s’efforcent de disposer d’une marge de manœuvre, tout en gardant une certaine confidentialité. Notre question de recherche porte sur les différents mécanismes de gouvernance qui peuvent encadrer la relation entre les capital-risqueurs et les entrepreneurs. Notre cadre théorique échafaude une double grille de lecture théorique en analysant cette relation selon les approches juridico-financière et cognitive de la gouvernance. Nos résultats montrent que les capital-risqueurs n’ont pas uniquement des impacts financiers, mais également des incidences organisationnelles et cognitives qui peuvent gouverner l’organisation interne de la société bénéficiaire. Le mode de gouvernance employé peut être influencé en grande partie par les caractéristiques individuelles, organisationnelles, institutionnelles et économiques des capital-risqueurs. De leur côté, les dirigeants des entreprises financées par le capital-risque peuvent avoir un comportement qui dépasse l’angle traditionnel de l’opportunisme dans lequel ils dissimulent leurs intérêts personnels pour qu’il soit générateur de ressources cognitives et contributeur à la création de valeur.
Gouvernance cognitive et gestion des risques : Boeing et ses projets hautement innovants
Authors: Marsal Christine
Published: September 2023

La dimension cognitive de la gouvernance prolonge les théories actionnariales en introduisant d’autres ressources nécessaires au développement de la firme : les ressources cognitives. C’est à travers le conseil d’administration que ces ressources peuvent être mobilisées. Utilisant la théorie de la dépendance des ressources, nous considérons cet apport dans le cas de la gestion des risques en contexte innovant. Notre étude de cas longitudinale fournit plusieurs illustrations. Elle montre que l’entreprise Boeing a conduit pendant 24 ans une démarche dynamique de gestion stratégique des ressources du CA. Ce faisant, elle s’est privée progressivement d’une ressource clé qui lui a fait cruellement défaut dans le développement des programmes 787 et 737 MAX. Le manque de diversité de son conseil peut expliquer en partie les déboires rencontrés par l’entreprise.
Facteurs déterminants des choix d’investissement portuaire : le cas des installations portuaires locales et régionales françaises
Authors: Fredouet Charles H.
Published: September 2023

Les ports jouent un rôle essentiel dans les processus de production et de distribution des entreprises ainsi que dans les réseaux mis en place par les prestataires logistiques et de transport. Toutefois, ils sont aussi susceptibles d’avoir à contribuer au développement des territoires dont ils font partie. Cet article vise à en savoir plus sur la façon dont ce double défi a des impacts sur les investissements faits par les ports locaux et régionaux. Àcet effet, 17 sites Internet individuels et 3 sites Internet collectifs de ports français ont été consultés. Les résultats montrent que les ports et les groupes de ports de l’échantillon se sont pour l’essentiel bien ajustés tant aux contraintes posées par les autorités publiques qu’aux besoins et attentes de leur clientèle actuelle et potentielle.
Pedagogical Support as an Improvement Strategy: A Bibliometric Review of The Literature in Scopus and Wos During 2018-2023
Authors: Vilchez-Valdivia Lizeth Paola , Cardoza-Sernaqué Manuel Antonio , Montenegro-Camacho Luis , Canchari-Preciado Miguel Ángel , Rivas-Mendoza Milagros Isabel , García-Ventura Cynthia Catherine
Published: September 2023

The objective of the present study was the analysis and quantification of the scientific literature by means of metrics in relation to the research consulted on pedagogical accompaniment as an improvement strategy, in the Scopus and WoS databases, in addition the period is delimited. Publication between 2018 and 2023. Based on a personalized bibliometric review methodology, where “pedagogical accompaniment” and “pedagogical accompaniment” were used as search words. Regarding the year with the greatest number of publications, it was 2022 (n=9); while the average number of citations per year the highest value was that of 2019; The keyword indicator showed that the most recurrent words in the study are: "pedagogical accompaniment", "teaching practice", "accompaniment of pupils' activities" and "professional development", the "Social Sciences Journals" and "Venezuelan Journal of Management" presented the largest scientific production related to the subject, each with 2 articles. Regarding the affiliation of the authors, in the Scopus articles it was the Central University of Ecuador (n=2); and in WoS the César Vallejo University/César Vallejo Private University (n=3); while the countries with the highest scientific production were Chile and Peru, each with 3 articles in the WoS database; The most frequent language of publication of the articles was English, both for Scopus and WoS, with 6 articles each; The thematic areas where the identified bibliography was located were three: arts and humanities, administration and business, and social sciences; Finally, the themes.
Etyczny wymiar globalizacji w kontekście nauczania Jana Pawła II
Authors: Hotloś Agnieszka
Published: September 2023

Tematyka związana z procesem globalizacji jest niezwykle ważna we współczesnym świecie. Niniejsze opracowanie wpisuje się w nurt licznych rozważań i publikacji dotyczących aktualnych przemian dokonujących się w skali całego globu. Ambiwalentny charakter globalizacji stawia szereg pytań o kształt przyszłej cywilizacji. Wśród tych pytań na pierwszy plan wysuwają się pytania dotyczące etyki i jej znaczenia w procesie globalizacji. Pomimo iż procesy globalizacji niosą ze sobą nowe wyzwania, to założenia etyczne, niezmienne w każdej epoce, pozostają aktualne także w obecnym czasie. Stąd, pośród zmienności świata, istnieje konieczność afirmacji człowieka, wskazania na jego godność osobową, a w konsekwencji kształtowania życia społecznego w oparciu o zasady solidarność i  sprawiedliwości, dopełnione miłością społeczną. Wszelkie próby redukowania człowieka do roli środka produkcji, elementu globalnego rynku sprowadzą proces globalizacji do zjawiska niszczącego to, co tak naprawdę ludzkie. Globalizacja pozbawiona odniesień etycznych prowadzi do wykluczenia jednostek i całych narodów, do nienawiści, pogardy dla słabszych, wzajemnej nieufności, konfliktów. W dobie kryzysu aksjologicznego etyka staje się jedną z najważniejszych dziedzin, które mogą zapewnić porządek społeczny. Celem niniejszego opracowania jest odpowiedź na pytanie: Jak ukierunkować proces globalizacji, aby  uwzględniał normy etyczne i tym samym służył dobru  jednostek i społeczeństw? Opracowanie skoncentrowane  jest kolejno wokół globalizacji i jej podstawowych  wymiarów, etycznych dylematów globalizacji, a w kluczowej części etycznych podstaw tego procesu.
Parafia 2.0. Wybrane narzędzia online w procesie podtrzymywania relacji we wspólnocie parafialnej w dobie pandemii Covid-19. Analiza historyczno-empiryczna
Authors: Kinal Jarosław
Published: September 2023

Celem artykułu jest prezentacja wstępnych badań empirycznych dotyczących obecności parafii we współczesnej przestrzeni wirtualnej. Rozwój technologiczny, którego naoczną egzemplifikacją jest społeczny wymiar Internetu, zmienił postrzeganie i zmodyfikował rytuały codzienności. Determinizm technologiczny, definiowany współcześnie jako znaczący wpływ technologii i rozwoju technologicznego na rozwój społeczny, jest w niektórych kręgach naukowych uznawany za dominującą instrukcję wyjaśniającą rewolucję cyfrową i relatywnie szybką absorpcję nowych mediów przez szerokie masy społeczne. Dodatkowo trwającaod 2020 roku pandemia wirusa SARS-CoV-2 jeszcze mocniej zaakcentowała potrzebę wykorzystywania mediów i technologii w codziennym życiu wspólnot parafialnych. W artykule zaprezentowano badania przeprowadzone na grupie 214 respondentów obejmujące problematykę funkcjonowania wspólnot parafialnych w przestrzeni wirtualnej i oceny działań przez respondentów.
Wiara praktyczna i jej funkcje. Szkic filozoficzny
Authors: Niemczuk Andrzej
Published: September 2023

Artykuł zawiera szkic koncepcji wiary praktycznej i prezentację dwóch ważnych funkcji, jakie koncepcja ta może pełnić w filozofii praktycznej. Idea wiary praktycznej jest syntezą opartą na interpretacji trzech koncepcji wiary: wiary moralnej z filozofii Kanta, wiary religijnej, na której oparte jest tzw. „trzecie stadium” życia w myśli Kierkegaarda oraz wiary filozoficznej przedstawionej w filozofii Jaspersa. Autor eksponuje te funkcje wiary praktycznej, dzięki którym transcenduje ona sferę wiedzy deskryptywnej. Dla filozofii praktycznej funkcje te mają ważne znaczenie, gdyż są podmiotowym źródłem akceptacji pierwszych zasad tej filozofii, czyli twierdzenia o wolności człowieka oraz twierdzenia o istnieniu sfery wartości (innej niż sfera faktów i bytów). Jeśli filozofia wartości byłaby logicznie oparta na wierze praktycznej, to byłaby wolna od zarzutu błędu naturalistycznego w aksjologii.
Znaczenie ogrodów biblijnych w hermeneutyce biblijnej
Authors: Polowiec Katarzyna
Published: September 2023

Jedną z możliwości nowej ewangelizacji są ogrody biblijne, które zaczęły powstawać na całym świecie. W ten sposób wspólnoty Kościołów w różnych krajach przyczyniają się do w nowego sposobu ewangelizowania i przybliżania Pisma Świętego. Zwiedzanie ogrodów biblijnych prowadzi do coraz lepszego poznania słowa Bożego, a także daje możliwość dotknięcia ziemi ojczystej Jezusa. Tworzone kompozycje roślin i małej architektury nie tylko ułatwiają poznanie warunków czasów biblijnych, lecz sprzyjają również modlitwie, medytacji i odpoczynkowi, ponadto są dobrym sposobem na poznanie fauny i flory Izraela. Kościół w Polsce od ponad 10 lat włącza się w tę formę przekazu wiary i zgłębiania słowa Bożego. W niniejszym artykule ukazano wybrane ogrody biblijne na świecie, zwracając szczególną uwagę na te, które dostępne są w Polsce.
Vomiting
Authors: Editorial Article
Published: September 2023

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Diarrhea
Authors: Editorial Article
Published: September 2023

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Resolution of the II All-Russian Vaccine Assembly «Protecting Generations»
Authors: Editorial Article
Published: September 2023

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Natural interconnections of ecosystems in wildlife
Authors: Lyashchuk Yuliya , Ovchinnikov Aleksey , Tuarmensky Vladimir
Published: September 2023

The article reflects the results of the analysis of mutualistic relationships in wildlife in the context. Examples of mutualism in wildlife are found everywhere. Mutualistic connections are considered in the work on the example of lichens (fungus and algae connection) and intestinal microbiota with the human body. The species diversity of lichens is quite large, as is their habitat, which is achieved due to the advantages that the mutualistic relationship provides. A striking example of mutualism Examples of mutualism among predators are much less common. The mutualistic interactions considered in the work clearly demonstrate that it is necessary to consider natural relationships in wildlife from the point of view of a systematic approach, comprehensively and voluminously. Since the components form an interconnected system, it is necessary to study and understand them in relation to network interaction, and not in isolation or in a limited subset of the system. It can be concluded that the network is, in fact, more than just a metaphor, it recognizes the inherent interconnectedness of ecosystem interactions. Networks consist of a set of objects with direct transactions (connections) between these objects. Although the exchange is a discrete transfer, these transactions, taken as a whole, connect the direct and indirect parts into an interconnected web, giving rise to a network structure. Thus, it is quite appropriate to consider interconnected systems as networks because of the powerful exploratory advantage that can be gained by using network analysis tools: graph theory, matrix algebra, and simulation, to name but a few.
Geocognitive mapping technology
Authors: Yankelevich Svetlana
Published: September 2023

The author of the article considers the need to develop a new direction in cartography due to the fact that human civilization has reached the threshold of a fundamentally new era of the existence of the economy and society — the era of knowledge. Adoption of effective management and project decisions in such areas as spatial (territorial) development of the Russian Federation, ensuring the defense and security of the country, cadastral registration of real estate objects, preservation of objects of historical and cultural heritage, environmental protection, use of natural resources, development of the domestic tourism industry, the design and construction of buildings and structures, science, education, etc., is impossible without the creation of modern cartographic software. The article discusses the process of creating and using cartographic products containing geospatial knowledge. The approach of thematic mapping considered by the author on the basis of geospatial knowledge of certain subject areas is presented by a set-theoretic description. The process of geocognitive mapping is represented by a technological scheme. A feature of the geocognitive mapping process is the use in the combination of professional knowledge in the fields of thematic cartography and each of the subject areas to be represented in thematic geospatial models and maps. On the basis of the above studies, the following methodological principle of mapping based on geoscience can be formulated: geospatial knowledge displayed on the map about a particular subject area is a set of information about the objects of this subject area, their properties and the relationships connecting them, the processes taking place in this subject area, as well as methods of analysis emerging situations and ways of solving certain problems this subject area by developing spatial solutions.
Modern trends in the development of the transport and logistics system of Russia, taking into account external challenges and transformations of the domestic market
Authors: Pyastolov Oleg , Arustamov Eduard , Demuriya Sofiko , Kravchenko Maria
Published: September 2023

The role and place of modern digital trends in logistics as the main factor that compensates and neutralizes the negative trends that arise in the current crisis post-pandemic conditions are considered. The article explores and analyzes the experience of foreign companies and leading domestic companies in the field of informatization and digitalization of business processes in transport logistics.
Current approaches to improving the control of the personnel of a commercial organization
Authors: Urusov Soltan , Turgaeva Aksana
Published: September 2023

This paper discusses modern approaches related to improving the process of personnel control in organizations. As an example, the author chose a medical institution of a dental profile. The author analyzed the activities of the enterprise, its main activities, and also identified the existing problems that are associated with insufficient control of personnel. A special place in the control structure is occupied by the motivation of employees, which in the organization under consideration is expressed both in material and intangible forms. The author identifies the key material incentives in the organization — cash payments for the achievement of goals, payroll payments to stimulate a healthy lifestyle for employees, as well as special individual rewards. Special attention is paid to non-material forms, which are realized to a lesser extent. Such incentives are reflected in the performance of employees, according to the author. In addition, the role of the social policy of the organization, which lies in the fact that it can take a large number of forms, is considered. At the same time, it largely affects not only the activities of individual employees, but also increases team cohesion and reduces tension between employees. The importance of improving control was confirmed by conducting a comparative analysis of the organization's activities in the periods before and after the introduction of new control methods. Thus, the effectiveness of many control measures, in particular video surveillance, was revealed. The author considered the consequences of improving the control system, which include partial replacement of employees with more conscientious ones, increased team cohesion, and improved economic performance.
Comparison of approaches to the concept of consumer protection
Authors: Plaksin Dmitry , Razin Ilya , Belousov Andrey
Published: September 2023

This publication is devoted to the study of the approaches of Russian authors to the definition of consumer protection. The Institute of Consumer Rights Protection has existed for several decades in our country and is the object of research for many specialists of the legal environment. The foundation for this institution was the rights and interests of exclusive economic entities that are part of the user segment. Considering that a widely developed conceptual apparatus is being implemented within the boundaries of this institution, this situation becomes especially important. We believe this is due to the fact that the content of this concept is assumed to be obvious — and this is fundamentally wrong. The concept reflects the essential features of the object, and therefore their incorrect reflection can lead to erroneous law-making activities and legal practice. In the article, the authors primarily separate the concepts of "consumer" and "protection of rights" in order to more deeply consider the structure of legal relations arising between a consumer and a business entity, as well as the internal features of consumer protection measures. It is worth emphasizing that special attention was paid to the definition of these concepts from a legal point of view. In addition, the definitions formulated by domestic authors were considered. The concept of consumer protection formulated by V.M. Kosoborodov stands out in particular. In the final part of the article, the authors focus on the fact that the conceptual apparatus in the business sector is not perfect. In this regard, this study was aimed at developing a more complete definition of consumer protection, since one of the main tasks of the state is the protection of human rights.
Analysis of outsourcing development in Russia: problems and prospects
Authors: Abbasov Abbas , Botasheva Lyudmila
Published: September 2023

In the scientific work, the author analyzes the state of outsourcing in Russia and the ways of its development. There is, according to the author, an increase in the total costs of attracting outside services and a change in the share of certain types in them. Thus, there is an increase in the popularity of audit services, recruitment services and security activities. Other indicators remain practically unchanged or decrease, which may be due to an increase in the supply of these services and, accordingly, a decrease in their prices. The author notes that outsourcing in Russia is developing, but not as intensively as abroad. Russian entrepreneurs have come to the realization that outsourcing increases efficiency and reduces costs, that its use is beneficial, but there are a number of constraints that prevent its active development. The author notes that there are a number of problems associated with insufficient awareness of entrepreneurs about the goals and benefits of outsourcing, as well as with the psychological characteristics of Russians. To improve the Russian outsourcing system, it is necessary to take measures that, in addition to creating the legal framework for the use of outsourcing, should include increasing entrepreneurial literacy, training qualified specialists in outsourcing management, as well as creating a single information space for firms providing outsourcing services and firms in need of them., to ensure effective communications. Carrying out these activities will give impetus to the further development of outsourcing in Russia, which will lead to GDP growth, improve the quality of products, as well as to strengthen Russia's integration into the global economic system and qualitative economic growth.
Views of Middle School Students on the Effectiveness of Science Courses Conducted with Biomimicry
Authors: AYDIN Betül , KAPTAN Dr. Fitnat
Published: September 2023

This study investigated the views of middle school students on the effectiveness of science courses conducted with biomimicry. To this end, phenomenological design, one of the qualitative research methods, was used. The study group consisted of 10 students in grades 5 and 7 who continued their education in a middle school located in the central district of Ankara province in the 2021-2022 academic year. Participants were determined through criterion sampling. The data collected through semi-structured interviews were analyzed using descriptive analysis. Based on the findings, codes and themes were created. According to the results of the study, students emphasized that science courses conducted with biomimicry activities increased their motivation and contributed to their academic and social development, as well as improving their creativity. In addition, due to the permanence of knowledge and the fun nature of the lessons, students also want to use biomimicry-based activities in other courses. In the study, how students overcame the challenges they faced was also examined. In this context, student responses indicated that the activities took too much time, they had difficulty deciding on the organism to be inspired by, and that a lot of thinking was required. Providing options for students to conduct biomimicry activities in areas of their interest will encourage greater participation. It is recommended to conduct more comprehensive studies on integrating biomimicry into science courses using different measurement tools and different study groups. It is thought that the widespread use of biomimicry activities will have a positive impact on students' motivation and academic achievement.
Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining Network Pharmacology, Molecular Docking, and Experimental Verification
Authors: Xu Liang
Published: September 2023

Objective: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and identify novel therapeutic targets.

Methods: Berberine-related targets were acquired from SuperPred, SwissTargetPrediction, and GeneCards. NSCLC-re-lated targets were collected from GeneCards and DisGeNET. Differentially expressed genes (DEGs) were identified GEO database, UCSC Xena, and limma. GO and KEGG analyses were performed using clusterProfiler. Autophagy-related genes and transcriptional factors were collected from HADb and KnockTF, respectively. STRING and Cytoscape were used for PPI network analysis. Immune cell infiltration in NSCLC was assessed using CIBERSORT, and its correlation with autophagy-related targets was evaluated. Molecular docking was conducted using PyMOL and AutoDock. qRT-PCR and CCK-8 assay was used for in vitro verification.

Results: Thirty intersecting targets of berberine-related targets, NSCLC-related targets, and DEGs were obtained. GO and KEGG analyses revealed that the intersecting targets were mainly implicated in oxidative stress, focal adhesion, and cell-substrate junction, as well as AGE-RAGE, relaxin, FoxO, and estrogen signaling pathways. Significantly, CAPN1, IKBKB, and SIRT2 were identified as the foremost autophagy-related targets, and 21 corresponding transcriptional factors were obtained. PPI network analysis showed that CAPN1, IKBKB, and SIRT2 interacted with 50 other genes. Fifty immune cell types, such as B cells naive, T cells CD8, T cells CD4 naive, T cells follicular helper, and monocytes, were implicated in NSCLC pathogenesis, and CAPN1, IKBKB, and SIRT2 were related to immune cells. Molecular docking revealed the favorable binding activity of berberine with CAPN1, IKBKB, and SIRT2. In vitro assays showed lower CAPN1, IKBKB, and SIRT2 expression in NSCLC cells than that in normal cells. Notably, berberine inhibited the viability and elevated CAPN1, IKBKB, and SIRT2 expression in NSCLC cells.

Conclusions: Berberine might treat NSCLC mainly by targeting CAPN1, IKBKB, and SIRT2.
SAĞLIK KURUMLARINDA YÖNETİM TARZLARININ ÖRGÜTSEL İKLİME ETKİSİNDE YÖNETİCİ KARİZMASININ ROLÜ: MALATYA ÖRNEĞİ
Authors: SÖNMEZ Sinem , DENİZ Mehmet
Published: September 2023

Hazırlanan araştırmada yönetim tarzlarının örgütsel iklime etkisi ve bu etkide yöneticinin sahip olduğu karizmanın nasıl rol aldığı incelenmiştir. Bu amaçla hazırlanan araştırmada veriler Malatya ilinde bulunan iki büyük sağlık kuruluşundan belirlenen örneklem aracılığıyla anket yöntemi ile toplanmıştır. Verilerin toplanmasında Yönetici Davranışları Ölçeği, Örgüt İklimi Ölçeği” ve yönetici karizmasının ölçülmesinde Çok Faktörlü Liderlik Ölçeği-Karizma Boyutu kullanılmıştır. Araştırmanın analizinde SPSS 26.0 programı ve SPSS ProcessV3 eklentisi kullanılmıştır. Buna göre yönetim tarzları ile örgütsel iklimi ve yönetici karizması arasında bir etki bulunmaktadır. Aynı zamanda yönetici karizması yönetim tarzının örgüt iklimine etkisinde aracılık etmektedir. Yönetim tarzlarının boyutları ile değerlendirildiğinde bu etkinin kısmi aracılık olduğu bulgulanmıştır. Araştırmanın sonucunda elde edilen bulgular genel olarak değişkenler arasında bir etki olduğunu doğrulamaktadır. Buna göre günümüzde önemi daha da belirginleşen sağlık alanında atılacak adımlarda yönetimin nasıl davranabileceği ve bunların çalışanları nasıl etkileyeceği gibi durumların önemi dikkat çekici bir sonuç olarak karşımıza çıkmaktadır.
SAĞLIK ÇALIŞANLARININ ALGILANAN ÖRGÜTSEL ADALET VE FARKLILIKLAR YÖNETİMİNİN İNSAN KAYNAKLARI VERİMLİLİĞİ ÜZERİNDEKİ ETKİSİ HAKKINDA GÖRÜŞLERİNİN DEĞERLENDİRİLMESİ: KAMU VE ÖZEL HASTANE ÖRNEĞİ
Authors: TARSUSLU Sinan , ÇİL KOÇYİĞİT Seyhan
Published: September 2023

Bu araştırma, sağlık çalışanlarında algılanan örgütsel adaletin ve farklılık yönetiminin insan kaynakları verimliliği üzerindeki etkisini tespit etmek amacıyla tasarlanmıştır. Bu amaçla çalışmada örgütsel adalet, farklılık yönetimi ve insan kaynakları verimlilik ölçekleri kullanıldı. Araştırma tipi tanımlayıcı – ilişki arayıcı tipte bir araştırmadır. Çalışma bir il merkezinde yer alan 3 kamu ve 1 özel hastanede aktif olarak görev yapan 2.215 çalışandan 437 kişiye ulaşılarak gerçekleştirilmiştir. Araştırmanın analizinde SPSS paket programı ile ölçek faktörlerinin doğrulanabilmesi için AMOS uygulaması kullanılmıştır. Araştırma verileri doğrultusunda örgütsel adalet ve insan kaynakları verimliliği arasında yüksek ve pozitif yönlü bir ilişki; farklılık yönetimi ile insan kaynakları verimliliği arasında ise orta düzeyde ve pozitif yönlü bir ilişki olduğu sonucuna ulaşılmıştır. Değişkenler arasında yapılan regresyon analizi sonuçlarına göre algılanan örgütsel adaletin ve farklılık yönetiminin insan kaynakları verimliliğini olumlu yönde etkilediği tespit edilmiştir. Son olarak algılanan örgütsel adaletin ve farklılık yönetiminin insan kaynakları verimliliği üzerindeki etkisini inceleyen bu çalışmanın sağlık sektöründe bir ilk olması nedeniyle yerli literatüre önemli katkılar sağlayacağı düşünülmektedir.
Concussion injury management, perception, and knowledge in amateur field hockey
Authors: King Caeleigh , Morris-Eyton Heather
Published: September 2023

Background: Field hockey has a high risk for sports-related concussion (SRC) injuries due to the speed and intensity of the game, current rules, field surfaces and equipment composition. Head injuries are the second most common reported injury and up to 75% of SRCs go unreported or undetected. This increases the subsequent injury risk, long term health consequences and prolonged injury recovery.
Objectives: This study aimed to examine the prevalence of SRC in hockey players within the Southern Gauteng Hockey Association (SGHA) premier league. Concussion knowledge and attitudes of hockey players, coaches, umpires, and officials were also investigated.
Methods: A partially mixed sequential dominant status design (QUANT–qual) was used, divided into two phases. In Phase One hockey players, coaches, umpires, and technical officials (n=119) completed a modified RoCKAS-ST questionnaire. In Phase Two, a focus group discussion with umpires (n=3) and interviews with coaches (n=3) were conducted.
Results: Injuries to the shoulder, neck, head, and face were reported from stick use (n=98); ball use (n=102) and collisions (n=187). Only 19% of hockey players were diagnosed with SRC, indicating that many of these injuries were undetected or not reported. Responses from the focus group discussion and interviews indicated that coaches, umpires, and officials felt they had insufficient knowledge of SRC.
Conclusion: The recognition and management of on-field injuries require improvement to enhance the injury detection system.
Cell Avidity analysis of murine CD8+ CAR T cells via z-Movi v1
Authors: R Stevens Andrew
Published: September 2023

z-Movi is a cell based assay used to assess the avidity of specific immune cells against their targets. Perform this protocol at the end of generating CAR-T cells. For more information see "Retroviral transduction of primary murine CD8 T cells". Target cell adhesion efficiency may vary between cell lines. Optimal chip-cell adhesion may be produced with adhesion media besides ConA, such as 0.01% Poly-L-Lysine. A cell-line specific protocol may be needed This protocol was completed using a variant of B16-F10. "B16-F10 is a cell line exhibiting a morphology of spindle-shaped and epithelial-like cells that was isolated from skin tissue of a mouse with melanoma". We transduced B16-F10 with plasmid pTS194 (see attached ApE file) (BF194) to ectopically express murine HER2 (mHER2) with puromycin resistance driven by a strong lentiviral promoter. Successfully transduced cells were selected for via screening for drug resistance, and confirmed via flow cytometry. For information on publications that used zMovi, please visit the link below: https://lumicks.com/products/z-movi-cell-avidity-analyzer/
Seawater virome concentration with Vivaflow v1
Authors: Varona Natascha
Published: September 2023

Concentration of viral particles from seawater samples using a Vivaflow.
Virus and Prokaryote Enrichment in Coral DNA Metagenomes v1
Authors: Varona Natascha
Published: September 2023

Tissue preparation and DNA extraction protocol for enrichment of viruses and prokaryotes in DNA metagenomes of corals.
The Effect of Technology-Supported Language Learning on Communication Competencies
Authors: MERZİFONLUOĞLU Ayşe , TAKKAÇ TULGAR Ayşegül
Published: September 2023

This study aimed to explore how technology-supported language learning affected the communication competencies of tertiary-level students. 48 prep-class students at the ELT department at a state university in Turkiye participated in the study. A mixed-method sequential explanatory design was employed to collect data that lasted 12 weeks. The quantitative data were obtained through a pre-questionnaire, a pretest and a posttest, and semi-structured interviews were used to collect qualitative data. The quantitative analysis showed that despite the improvement in the students’ performance, a statistically significant difference was not found between the scores of the experimental and control groups concerning their communication proficiency levels. However, the conventional content analysis indicated that technology-supported language learning provided the participants with a rich content, enhanced interaction, collaboration, individualization, an enjoyable learning setting, an opportunity to see progress and flexibility in terms of time and space. Based on the findings of this study, it is recommended to integrate technology into the language learning process for the improvement of communication skills.
A PERSPECTIVA DE GÊNERO NA FORMAÇÃO DOCENTE: POR UMA PRÁTICA PEDAGÓGICA QUE EDUQUE PARA EQUIDADE
Authors: De Oliveira Borges Vanessa Maria
Published: September 2023

O presente artigo se propõe a refletir sobre a importância dos processos formativos de professores, com recorte para a formação inicial em pedagogia, no intuito de coibir a reprodução de estereótipos e preconceitos relativos à categoria de gênero, capacitando docentes para educar meninos e meninas para superar diferenças, e não para conformar a manutenção de papeis sociais desiguais. Desse modo, o objetivo principal desta investigação é identificar como a inclusão da perspectiva de gênero na formação inicial docente pode contribuir para uma educação emancipatória e não discriminatória. Para alcançar esse objetivo, a pesquisa se estruturou a partir de critérios qualitativos e foi pautada em um levantamento bibliográfico e posterior aplicação de questionário com perguntas objetivas e subjetivas sobre o tema, para que os(as) estudantes do curso de Licenciatura do Centro Universitário Jorge Amado (BA) pudessem narrar livremente suas experiências acerca das perspectivas de gênero em suas formações em pedagogia.
Análise dos Indicadores de Qualidade em uma Unidade de Terapia Intensiva Adulto: Um Estudo Descritivo
Authors: Paz Diego Dias , Souza Laylla Meireles de , Brinati Lídia Miranda , Coutinho Juliana de Souza Lima , Souza Silvânia Medina de , Correia Marisa Dibbern Lopes , Toledo Luana Vieira
Published: September 2023

Objetivo: Analisar os resultados obtidos pelos indicadores de qualidade em assistência à saúde monitorados em uma unidade de terapia intensiva adulto. Método: Estudo descritivo com análise retrospectiva dos relatórios de indicadores de uma unidade de terapia intensiva adulto. Resultados: Dos 33 indicadores, nove referem-se ao funcionamento global do setor, destacando-se a baixa taxa de reinternação em 24 horas (0,8%); 14 referem-se aos dispositivos invasivos, com predomínio da utilização de cateteres vesicais de demora (63,2%), venosos periféricos (59,8%) e nasogástricos/nasoentéricos (50,0%); seis referem-se a incidentes não infecciosos, destacando-se a incidência de lesão por pressão (5,2%), obstrução (2,7%) e remoção de cateter nasogástrico/nasoentérico (2,3%); e quatro abordam os incidentes infecciosos, com destaque para a densidade de incidência de pneumonia associada à ventilação mecânica (37,8 por 1000 pacientes-dia). Conclusão: Foram observados aspectos positivos, como o predomínio de altas hospitalares e baixa taxa de reinternação, e aspectos negativos, como a ocorrência de incidentes.
Types of Personal Changes of Future Specialists, Psychologists-Psychotherapists
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Yavorska Аnastasiya
Published: September 2023

Background. Socio-political processes exacerbated the problems of psychological assistance to citizens; training of qualified psychologists-therapists. One of the factors of a specialist's personality is the ability for personal change. The goal is to reveal the content of the main factors of personal changes of future psychologists-therapists Methods. The research used the "Big Five" methods; Herzberg's test; "Diagnostics of socio-psychological personality attitudes" (O. Potemkina); "Value questionnaire" (Sh. Schwartz); "Research of volitional self-regulation" (A. Zverkov, E. Eidman); "Diagnostics of motivational orientations in interpersonal communications" (I. Ladanov, V. Urazaeva); "Motivation of professional activity" (K. Zamfir); "Test of social intelligence" (J. Gilford); "Self-Assessment Questionnaire" (V. Stolin, S. Pantileev); "Scale of psychological well-being" (K. Riff) - separate scales from which factors of personal changes were included. Results. As a result of factor analysis using the method of principal components, four factors of personal changes of future psychologists- therapists were identified: 1) "pattern" - tendency to change, voluntary self-control, responsibility, ability to achieve personal success, openness to experience, orientation to the process, independence, universalism, inner type motivation and general self-regulation, social thinking, psychological well-being; 2) "personal-purpose" - social recognition, achievement of personal success, content of work, orientation to results, power, compromise; hedonism, self-control, internal and external positive motivation, self-acceptance; 3) "professional-purpose" - pleasantness, cooperation, work content, process orientation, money; selfishness, kindness, external positive and negative motivation; 4) "pragmatic-humanistic" - extraversion, neuroticism, cooperation, altruism, independence, security, orientation towards acceptance of others, positive relationships. Сonclusion. The process of unfolding individual personal states and traits is the development of the personality, therefore personal changes are the development of the personality. The concept of personal change (personal changes) is generic to the concept of personality development, since the latter involves the specification of personal formations according to the criteria of their complexity and specification, therefore the concepts of change and personality change are different.