bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends, Figures 1 - 6 from Endothelial Cell-Secreted EGF Induces Epithelial to Mesenchymal Transition and Endows Head and Neck Cancer Cells with Stem-like Phenotype
Authors: Zhang Zhaocheng , Dong Zhihong , Lauxen Isabel S. , Filho Manoel Sant'Ana , Nör Jacques E.
Published: March 2023

PDF file - 524KB, Supplementary Figure 1. Endothelial cell-secreted EGF induces phenotypic changes consistent with EMT in head and neck squamous cell carcinoma cells. Supplementary Figure 2. Endothelial cell-secreted factors enhance the motility of HNSCC. Supplementary Figure 3. Endothelial cell-secreted factors activate STAT3, Akt and ERK signaling. Supplementary Figure 4. Endothelial cell-secreted EGF induces Snail expression via PI3K/Akt signaling. Supplementary Figure 5. EGF enhances the fraction of cancer stem-like cells. Supplementary Figure 6. Endothelial cell-secreted EGF dose not increase blood vessel density in tumors in vivo.
Supplementary Figure Legend from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: March 2023

PDF file - 64K
Supplementary Figure 4 from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: March 2023

Supplementary Figure 4 PDF File - 107K, Cells expressing endogenous FOXC2 exhibit increased sensitivity to sunitinib (a) Quantification of HMLE-Snail and (b) SUM159 cell viability expressing either shControl or shFOXC2, following culture for 96 hours in increasing concentrations of sunitinib. Cell viability was assessed using an MTS assay. (c) In vitro quantification of mammospheres formed by cells described above grown in the presence of sunitinib. Data represents the number of mammospheres formed per 1000 cells seeded after 7 days of culture. Error bars indicate SEM. * P<0.05
Supplementary Tables 1 - 4 from p53 Is Positively Regulated by miR-542-3p
Authors: Wang Yemin , Huang Jen-Wei , Castella Maria , Huntsman David George , Taniguchi Toshiyasu
Published: March 2023

PDF file - 117KB, Summary of miRNA mimic library screen to identify miRNAs that regulate p53 expression (S1). Top Canonical Pathways affected by miR-542-3p in U2OS cells (S2). Components of p53 signaling pathway that were significantly affected by miR-542-3p in U2OS cells (S3). Components of ribosome that were modulated by miR-542-3p in U2OS cells (S4).
Supplementary Figure 4 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: March 2023

PDF file - 5347K, Illustration of CC3 IHC image analysis. Bright-field images of CC3 IHC were imported into ImageJ. Automated local thresholding (Niblack method) and watershed segmentation were used to identify all nuclei, and total nuclear area was calculated. Dark CC3 positive areas were subsequently identified using a predetermined intensity-based threshold, and the area representative of these regions was calculated, enabling us to calculate % CC3 positive area as a function of total nuclear area.
Supplementary Figure 1 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: March 2023

PDF file - 2507K, Tumors in PPwt/loxpM mice display MBEN histology, similar to PPM tumors, demonstrated by H&E staining. Scale bars represent 1 mm in the low magnification images, and 100 microm in the high magnification images.
Supplementary Movie 2 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: March 2023

MP4 file - 1594K, 3D model of melanoma brain metastases in a mouse
Supplementary Methods, Figure Legends 1-3 from Tissue Damage–Associated “Danger Signals” Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer
Authors: He Ying , Zha Jikun , Wang Yamin , Liu Wenhua , Yang Xuanming , Yu Ping
Published: March 2023

PDF file - 106K
Supplementary Figure 3 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: March 2023

PDF file - 241K, SPIONs do not influence cell migration and growth in vitro
Supplementary Table 1 from MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Authors: Tovar Christian , Graves Bradford , Packman Kathryn , Filipovic Zoran , Xia Brian Higgins Mingxuan , Tardell Christine , Garrido Rosario , Lee Edmund , Kolinsky Kenneth , To Kwong-Him , Linn Michael , Podlaski Frank , Wovkulich Peter , Vu Binh , Vassilev Lyubomir T.
Published: March 2023

PDF file - 12K, Antitumor activity of RG7112 against a panel of solid tumor cells.
Supplementary Figure 4 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: March 2023

PDF file, 74K, PD-1 or PD-L1 blockade increases immune activation of TILs in ID8 tumor.
Supplementary Figure 1 from Preclinical Evidence That PD1 Blockade Cooperates with Cancer Vaccine TEGVAX to Elicit Regression of Established Tumors
Authors: Fu Juan , Malm Ian-James , Kadayakkara Deepak K. , Levitsky Hy , Pardoll Drew , Kim Young J.
Published: March 2023

PDF file - 3450KB, Colocalization of CD8 T-cells with PD-L1 expression.
Supplementary Methods from NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis
Authors: Qin Li , Wu Ye-Lin , Toneff Michael J. , Li Dabing , Liao Lan , Gao Xiuhua , Bane Fiona T. , Tien Jean C.-Y. , Xu Yixiang , Feng Zhen , Yang Zhihui , Xu Yan , Theissen Sarah M. , Li Yi , Young Leonie , Xu Jianming
Published: March 2023

PDF file - 155KB
Supplementary Figure 4 from NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis
Authors: Qin Li , Wu Ye-Lin , Toneff Michael J. , Li Dabing , Liao Lan , Gao Xiuhua , Bane Fiona T. , Tien Jean C.-Y. , Xu Yixiang , Feng Zhen , Yang Zhihui , Xu Yan , Theissen Sarah M. , Li Yi , Young Leonie , Xu Jianming
Published: March 2023

PDF file - 69KB, qPCR measurement of NCOA1 mRNA and mCsf1 mRNA in Tg(Neu) and Tg(NCOA1)xTg(Neu) mouse mammary gland tumor cells transfected with non-targeting control siRNA, NCOA1 siRNA, or mCsf1 siRNA.
Supplementary Methods, Figure Legends, Tables 1 - 9 from Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
Authors: Lindner Andreas U. , Concannon Caoimhín G. , Boukes Gerhardt J. , Cannon Mary D. , Llambi Fabien , Ryan Deborah , Boland Karen , Kehoe Joan , McNamara Deborah A. , Murray Frank , Kay Elaine W. , Hector Suzanne , Green Douglas R. , Huber Heinrich J. , Prehn Jochen H.M.
Published: March 2023

PDF file - 237K, Supplementary Table 1: Translation of protein interactions into Ordinary Differential Equations. Supplementary Table 2: Pseudo-reactions for degradation and degradation rates as used in the model. Supplementary Table 3: Pseudo-reactions and kinetics for inhibition of BH3 only proteins and effectors BAK and BAX by anti-apoptotic proteins. Supplementary Table 4: BAK and BAX activation and BAK inhibition by VDAC2. Supplementary Table 5: Effector homo-oligomerization. Supplementary Table 6: Modeling apoptosis sensitizers ABT-737 and ApoG2. Supplementary Table 7 Two tBID chimeras were modeled to reproduce the findings of Llambi et al. Supplementary Table 8: BCL2 protein quantification of CRC cell lines. Supplementary Table 9: BCL2 protein quantification of CRC patient samples.
Supplementary Table 3 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 9K, Summary of sequencing statistics from RNAseq analysis of 106 FFPE RNA samples.
Supplementary Tables 1 - 5 from Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways
Authors: Verhaegh Wim , van Ooijen Henk , Inda Márcia A. , Hatzis Pantelis , Versteeg Rogier , Smid Marcel , Martens John , Foekens John , van de Wiel Paul , Clevers Hans , van de Stolpe Anja
Published: March 2023

PDF file - 131KB, Wnt target genes and probesets (S1). ER target genes and probesets (S2). Used datasets (S3). Variation in predicted probability of pathway activity between and within cell lines, assessed on dataset E-MTAB-37 (S4). Gene set enrichment analysis results on normal colon samples versus colon adenoma from GSE8671 (S5).
Supplementary Figure 1 from Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways
Authors: Verhaegh Wim , van Ooijen Henk , Inda Márcia A. , Hatzis Pantelis , Versteeg Rogier , Smid Marcel , Martens John , Foekens John , van de Wiel Paul , Clevers Hans , van de Stolpe Anja
Published: March 2023

PDF file - 174KB, Variation of predicted ER pathway activity for sample replicates.
Supplementary Table 1 from The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Authors: Gutschner Tony , Hämmerle Monika , Eißmann Moritz , Hsu Jeff , Kim Youngsoo , Hung Gene , Revenko Alexey , Arun Gayatri , Stentrup Marion , Groß Matthias , Zörnig Martin , MacLeod A. Robert , Spector David L. , Diederichs Sven
Published: March 2023

XLSX file - 564K, Supplementary Table S1: This table lists 459 genes that show a differential expression upon loss of MALAT1 in A549 lung cancer cells.
Supplementary Methods, Figures 1 - 4, Tables 2 - 6 from The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Authors: Gutschner Tony , Hämmerle Monika , Eißmann Moritz , Hsu Jeff , Kim Youngsoo , Hung Gene , Revenko Alexey , Arun Gayatri , Stentrup Marion , Groß Matthias , Zörnig Martin , MacLeod A. Robert , Spector David L. , Diederichs Sven
Published: March 2023

PDF file - 808K, Supplementary Figure S1: This figure depicts the impact of MALAT1 loss on gene expression, splicing and SR protein phosphorylation. Supplementary Figure S2: This figure describes the generation of MALAT1-Knockout A549 cells using an independent ZFN as well as their phenotypes regarding proliferation and MALAT1 target gene expression. Supplementary Figure S3: This figure displays the impact of loss of MALAT1 using an independent ZFN in A549 cells on cell migration. Supplementary Figure S4: This figure documents that Antisense Oligonucleotides (ASOs) are effective in silencing MALAT1 in vitro without affecting cell proliferation of EBC-1 cells. Supplementary Table S2: This table lists 23 genes whose differential expression (5 up / 18 down) in MALAT1 KO cells was validated via qRT-PCR and who had been previously identified with critical roles in lung cancer, migration, invasion, EMT or metastasis. Supplementary Table S3: This table lists the sequences of all primers used for qRT-PCR in 5'-3' direction. Supplementary Table S4: This table lists the sequences of all primers used for splicing analysis in 5'-3' direction. Supplementary Table S5: This table lists the sequences of all primers and probes used for TaqMan qRT-PCR in 5'-3' direction. Supplementary Table S6: This table lists the sequences of all Antisense Oligonucleotides (ASOs) in 5'-3' direction. Supplementary Methods: This chapter provides experimental details on the RNA isolation and DNase I digest, reverse transcription and quantitative PCR, exon microarray analysis, antisense oligonucleotides (ASOs), lung imaging by microCT scan, immunohistochemistry and in situ hybridization, statistical analysis, generation of ZFN-2 clones, cell proliferation assays, SDS-PAGE and Western blotting.
Supplementary Figure 3 from Transient Induction of ING4 by Myc Drives Prostate Epithelial Cell Differentiation and Its Disruption Drives Prostate Tumorigenesis
Authors: Berger Penny L. , Frank Sander B. , Schulz Veronique V. , Nollet Eric A. , Edick Mathew J. , Holly Brittany , Chang Ting-Tung A. , Hostetter Galen , Kim Suwon , Miranti Cindy K.
Published: March 2023

PDF file - 134KB, Constitutive Myc expression leads to cell death after differentiation.
Supplementary Tables 1 - 2 from Hypomethylating Therapy in an Aggressive Stroma-Rich Model of Pancreatic Carcinoma
Authors: Shakya Reena , Gonda Tamas , Quante Michael , Salas Martha , Kim Samuel , Brooks Jenna , Hirsch Steffen , Davies Justine , Cullo Angelica , Olive Kenneth , Wang Timothy C. , Szabolcs Matthias , Tycko Benjamin , Ludwig Thomas
Published: March 2023

PDF file - 421K, Supplementary Table S1A. Results from mRNA expression profiling in PDAC cells. Supplementary Table S1B. Results from mRNA expression profiling in CAFs. Supplementary Table S2A. Highest ranked gene sets from GSEA of the PDAC expression data. Supplementary Table S2B. Highest ranked gene sets from GSEA of the CAF expression data.
Supplementary Figure 2 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Authors: Russell Mike R. , Levin Kirill , Rader JulieAnn , Belcastro Lili , Li Yimei , Martinez Daniel , Pawel Bruce , Shumway Stuart D. , Maris John M. , Cole Kristina A.
Published: March 2023

PDF file - 48K, Wee1 and Chk1 expression are elevated in high-risk, MYCN-amplified neuroblastoma. Primary tumors were obtained from 251 patients at diagnosis (221 high-risk, 30 low-risk; 68 MYCN amplified, 183 MYCN non-amplified), and were run on Affymetrix Human Exon 1.0 ST expression microarrays. Both Wee1 and Chk1 expression were expressed at a significantly higher rate in both the MYCN amplified and high-risk conditions
Supplementary Movie 2 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: March 2023

MOV file - 3841K, Movie before (left) and after (right) EB3-GFP comet detection (blue dots) with plusTipTracker, acquisition of 125 frames, 1.25 Hz, 12.5 fold accelerated.
Supplementary Figure S4 from Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy
Authors: Lim Seon Ah , Kim Tae-Jin , Lee Jung Eun , Sonn Chung Hee , Kim Kwanghee , Kim Jiyoung , Choi Jong Gwon , Choi Il-Kyu , Yun Chae-Ok , Kim Jae-Hong , Yee Cassian , Kumar Vinay , Lee Kyung-Mi
Published: March 2023

Supplementary Figure S4 PDF file - 1618K, Twenty-eight surface markers associated with activation, cytotoxicity, and differentiation were analyzed by flow cytometry on the gated NK population from the PBMC of patients with cancer on Day 0 (rest, pre-activation) and Day 11 (activation, post-expansion)
Supplementary Figure 1 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: March 2023

PDF file - 265K, Variation in control movies and between individual siRNA oligos.
Supplementary Figure Legend from FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Cuevas Rolando , Korzeniewski Nina , Tolstov Yanis , Hohenfellner Markus , Duensing Stefan
Published: March 2023

PDF file - 70K
Supplementary Figure 5 from FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Cuevas Rolando , Korzeniewski Nina , Tolstov Yanis , Hohenfellner Markus , Duensing Stefan
Published: March 2023

PDF file - 654K, Endogenous and overexpressed CEP57 show a centrosomal expression pattern in LNCaP prostate cancer cells.
Supplementary Methods, Figures 1 - 6, Tables 1 - 4 from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
Authors: Zhou Min , Wang Hai , Zhou Keke , Luo Xiaoying , Pan Xiaorong , Shi Bizhi , Jiang Hua , Zhang Jiqin , Li Kesang , Wang Hua-Mao , Gao Huiping , Lu Shun , Yao Ming , Mao Ying , Wang Hong-Yang , Yang Shengli , Gu Jianren , Li Chuanyuan , Li Zonghai
Published: March 2023

PDF file - 734K, Figure S1. EGFRvA is widely expressed in various cancer cell lines and tissues. Figure S2. The upregulation of EGFRvA in glioma tissues compared with paired adjacent non-neoplastic brain tissues and a poor prognosis in patients with high-grade gliomas. Figure S3. EGFRvA promotes cell migration and invasion in vitro and in vivo. Figure S4. EGFRvA caused the activation of STAT3 and increased expression of HB-EGF. Figure S5. The positive feedback regulation between HB-EGF and p-STAT3 in EGFRvA-expressing cells. Figure S6. Cell viability and cell adhesion of U87MG EGFRvA cells treated with STAT3 inhibitor AG490, and siRNA-mediated knockdown of STAT3 in U87MG transfectants. Table S1. Clinical characteristics of patients with low or high expression of EGFR or EGFRvA in 52 glioma patients. Table S2. Higher expressed genes in U87MG EGFRvA cells versus U87MG EGFR cells. Table S3. Lower expressed genes in U87MG EGFRvA cells versus U87MG EGFR cells. Table S4. Primers used in this study.
Supplementary Table S1 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Table S1 PDF File - 52K, Number of tumors observed in the lungs 20 and 30 days post-injection for parental NCI-H460 cells and clones NCI-H460 WT Ark 1 and NCI H460 Ark 11
Supplementary Figure S7 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Figure S7 PDF File - 21K, Knockdown of Arkadia in MTLN3E and B16 cells inhibits TGF-�-induced Smad3-dependent transcription
Supplementary Figure 7 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: March 2023

PDF file - 103KB, Nos1 is dispensable for the growth of CXCL14 fibroblasts under conditions of oxidative stress but important for their paracrine-mediated effects.
Supplementary Figure S4 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Figure S4 PDF File - 152K, Molecular characterization of MDA-MB-231 cells stably expressing FLAG-tagged Arkadia C937A
Supplementary Figure S3 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Figure S3 PDF File - 152K, Deletion or mutation of Smad4 results in a resistance to TGF-�-induced Ski and SnoN degradation
Supplementary Figure S2 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Figure S2 PDF File - 454K, Restoration of Arkadia activity in NCI-H460 cells does not affect cell proliferation
Supplementary Figure 3 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: March 2023

PDF file - 53KB, Enhanced activation of Hif1α-signaling in CXCL14-fibroblasts.
Supplementary Figure Legend, Methods, Tables 1 - 2 from Earlier Detection of Breast Cancer with Ultrasound Molecular Imaging in a Transgenic Mouse Model
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Lutz Amelie M. , Gambhir Sanjiv S. , Tranquart Francois , Tian Lu , Willmann Jürgen K.
Published: March 2023

PDF file - 116K, Table S1: Summary of Sensitivity, Specificity, Positive and Negative Predictive Values for Differentiating Benign (Normal, Hyperplasia) from Malignant (DCIS, Invasive Cancer) Pathologies Based on Different Imaging Signal Threshold Levels; Table S2a: Summary of Sensitivity, Specificity, Positive and Negative Predictive Values for Differentiating Benign (Normal, Hyperplasia) from DCIS Based on Different Imaging Signal Threshold Levels; Table S2b: Summary of Sensitivity, Specificity, Positive and Negative Predictive Values for Differentiating Benign (Normal, Hyperplasia) from Invasive Cancer Based on Different Imaging Signal Threshold Levels.
Supplementary Figure 5 from CHD1 Is a 5q21 Tumor Suppressor Required for ERG Rearrangement in Prostate Cancer
Authors: Burkhardt Lia , Fuchs Sarah , Krohn Antje , Masser Sawinee , Mader Malte , Kluth Martina , Bachmann Frederik , Huland Hartwig , Steuber Thomas , Graefen Markus , Schlomm Thorsten , Minner Sarah , Sauter Guido , Sirma Hüseyin , Simon Ronald
Published: March 2023

PDF file - 636K, Impact of CHD1 on colony formation, soft agar growth and cell invasiveness. a) Effect of CHD1 overexpression on cell growth. DU-145 cells were transfected with expression vectors encoding CHD1, PLNGY (control) and the known tumor suppressor genes RB1 and PTEN. Effect of CHD1 depletion on cell growth. DU-145 cells were transfected with shCHD1 vector. The control group consisted of shGFP, shRB1 and shPTEN vectors. Cells were selected with puromycin and cultured for two weeks, and colonies were fixed with methanol and stained with Giemsa. b) Soft agar assay showing the impaired anchorage-independent growth of shCHD1 PC-3 cells and control shNeg cells. Representative images of the stained colonies are shown. The bars represent the average number of colonies. c) CHD1 knockdown impairs invasion of PC-3 (shCHD1) cells through matrigel as compared to shNeg control cells. Photographs show representative fields of crystal-violet stained invading cells.
Supplementary Figures 1 - 9 from T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing
Authors: Kudo Ko , Imai Chihaya , Lorenzini Paolo , Kamiya Takahiro , Kono Koji , Davidoff Andrew M. , Chng Wee Joo , Campana Dario
Published: March 2023

PDF file - 300K, Schematic representation of CD16 chimeric receptors used in this study (S1); Expression of CD16V-BB-Z receptor in T-cell subsets (S2); Relative capacity of CD16V-BB-Z and CD16F-BB-Z receptors to bind Trastuzumab and human IgG (S3); Results of 4-hour in vitro cytotoxicity assays (S4); Cytotoxicity of CD16V-BB-Z T lymphocytes is powerful, specific and is not affected by unbound IgG (S5); T lymphocytes expressing CD16V-BB-Z receptors exert anti-tumor activity in vivo (S6); Functional differences between T lymphocytes expressing CD16VBB-Z and CD16F-BB-Z receptors (S7); Expression of CD16V receptors with different signaling domains (S8); Cytotoxicity mediated by T lymphocytes expressing either CD16VBB-Z or anti-CD19-BB-Z receptors against Daudi cells in the presence of two different concentrations of Rituximab (S9).
Supplementary Figure 1 from CHD1 Is a 5q21 Tumor Suppressor Required for ERG Rearrangement in Prostate Cancer
Authors: Burkhardt Lia , Fuchs Sarah , Krohn Antje , Masser Sawinee , Mader Malte , Kluth Martina , Bachmann Frederik , Huland Hartwig , Steuber Thomas , Graefen Markus , Schlomm Thorsten , Minner Sarah , Sauter Guido , Sirma Hüseyin , Simon Ronald
Published: March 2023

PDF file - 68K, Localization of the CHD1 FISH probe made from two BAC clones relative to the CHD1 gene.
Supplementary Figure Legends from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: March 2023

PDF file - 85KB
Supplementary Figure Legend from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 80K
Supplementary Figure 6 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 40K, Computational modeling of in vivo response to therapy.
Supplementary Methods from Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer
Authors: Cheng Pingyan , Kumar Vinit , Liu Hao , Youn Je-In , Fishman Mayer , Sherman Simon , Gabrilovich Dmitry
Published: March 2023

PDF - 40K, Description of additional methods and procedures used in the study.
Supplementary Figure 1 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 50K, Loss of membrane motion precedes loss of innate fluorescence in MM fluorescent cell line.
Supplementary Materials and Methods from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Authors: Schlecker Eva , Fiegler Nathalie , Arnold Annette , Altevogt Peter , Rose-John Stefan , Moldenhauer Gerhard , Sucker Antje , Paschen Annette , von Strandmann Elke Pogge , Textor Sonja , Cerwenka Adelheid
Published: March 2023

PDF file - 87KB
Supplementary Figure 2 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Authors: Schlecker Eva , Fiegler Nathalie , Arnold Annette , Altevogt Peter , Rose-John Stefan , Moldenhauer Gerhard , Sucker Antje , Paschen Annette , von Strandmann Elke Pogge , Textor Sonja , Cerwenka Adelheid
Published: March 2023

PDF file - 79KB, Pharmacological inhibition of protein disulfide isomerases reduces soluble B7-H6.
Supplementary Figure 2 from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: March 2023

PDF file - 122K, Supplemental figure 2: Oncogenic events induced an increase in AMPK nuclear localization and Rb phosphorylation, while mTOR pathway is maintained at low level of activation.
Supplementary Figure 1 from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: March 2023

PDF file - 61K, Supplemental figure 1: Characterization of astrocytes with HRasV12 expression and/or Pten deletion.
Supplementary Figure Legends from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: March 2023

PDF file - 73KB
Supplementary Figure 1 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: March 2023

PDF file - 172K, Proteasome inhibition reverses the impact of GA on phospho-MET and total MET protein expression.
Supplementary Figure 4 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: March 2023

PDF file - 150KB, Supplementary Figure 4 Validation of the specificity of anti-LSECtin.
Supplementary Figure 1 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: March 2023

PDF file - 108KB, Supplementary Figure 1 LSECtin is induced to be expressed by murine melanoma tissues.
Supplementary Table 2 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: March 2023

PDF file - 61K, Gr1high and Gr1low cell subsets in mouse blood and spleen
Supplementary Figure 7 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: March 2023

PDF file - 113K, The expression of chemokine receptors by tumor-associated macrophages (TAMs)
Supplementary Methods and Figures 1 - 6 from The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
Authors: Kaucká Markéta , Plevová Karla , Pavlová Šárka , Janovská Pavlína , Mishra Archana , Verner Jan , Procházková Jiřina , Krejčí Pavel , Kotašková Jana , Ovesná Petra , Tichý Boris , Brychtová Yvona , Doubek Michael , Kozubík Alois , Mayer Jiří , Pospíšilová Šárka , Bryja Vítězslav
Published: March 2023

PDF file - 695K, S. figure 1mRNA from CD19+ cells of healthy individuals. S. figure 2 Expression of Wnt-5a in the samples shown in Fig. 1 was determined by qRT-PCR. S. figure 3 Viability of primary CLL cells stimulated with the indicated compounds have been assessed by the WST1 test. S. figure 4 mRNA from MEC1 cells and from B-cells of healthy individuals was isolated and the expression of the indicated genes was analyzed by real time qRT-PCR. S. figure 5 Flow-cytometric analysis of apoptosis in patient CLL cells used for transplantation. S. Figure 6 Expression of PRICKLE1.
Supplementary Figure 7 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: March 2023

PDF file - 65K, Markers of epithelial-mesenchymal transition are unaffected by Bcl3 loss
Supplementary Figure 6 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: March 2023

PDF file - 31K, Migration of MG1361 cells in boyden chamber assays correlated with Bcl3 mRNA levels
Supplementary Figure 5 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: March 2023

PDF file - 377K, Stem cell-like activity is not reduced by the suppression of Bcl3
Supplementary Tables 1 - 7 from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance
Authors: Ng Charlotte K.Y. , Weigelt Britta , A'Hern Roger , Bidard Francois-Clement , Lemetre Christophe , Swanton Charles , Shen Ronglai , Reis-Filho Jorge S.
Published: March 2023

PDF file - 108K, Impact of strength of the spiked-in gene expression changes on signature performance (S1); Performance of gene signatures according to the strength of the spiked-in gene expression changes (S2); Impact of distinct mechanisms of resistance on signatures generated using superPC (S3); Impact of signature strength on signature performance, when signatures are generated with SuperPC (S4); Impact of unevenly distributed but similarly prevalent resistance mechanisms in the training and test sets on signature performance (S5); Impact of different distributions of resistance mechanisms in training and test sets on signature performance (S6); Impact of overlapping gene signatures on signature performance (S7).
Supplementary Figure S1 from LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Authors: Cox Thomas R. , Bird Demelza , Baker Ann-Marie , Barker Holly E. , Ho Melisa W-Y. , Lang Georgina , Erler Janine T.
Published: March 2023

Supplementary Figure S1 PDF file - 1024K, Co-expression of fibrotic markers and other LOX family members during pulmonary fibrosis
Supplementary Table 1 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: March 2023

PDF file - 54K, Mutations analysis in primary leukemia blasts.
Supplementary Methods from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: March 2023

PDF file - 64K, Primary antibodies and cell lines generation
Supplementary Figure Legend from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: March 2023

PDF file - 85K
Supplementary Video 1 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Authors: Sinnott Rebecca , Winters Leah , Larson Brittany , Mytsa Daniela , Taus Patrick , Cappell Kathryn M. , Whitehurst Angelique W.
Published: March 2023

AVI - 127K, Video of a HCC366 micronucleated cell undergoing mitosis.
Supplementary Figures 1 - 7 from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche
Authors: Infanger David W. , Cho YouJin , Lopez Brina S. , Mohanan Sunish , Liu S. Chris , Gursel Demirkan , Boockvar John A. , Fischbach Claudia
Published: March 2023

PDF file - 1076K, Immunofluorescence staining of GBM CSCs cultured in the presence of serum and absence of EGF and bFGF (S1); Tumors formed from CSC-seeded PLG scaffold implantation exhibit clinical features of human GBM (S2); Vascular characteristics of tumors formed from PLG scaffold implantation (S3); CSC differentiation is impaired by 3-D hCMEC paracrine signaling cues (S4); Control experiments evaluating IL-8-induced chemotaxis and gene expression in CSCs (S5); Targeted knockdown of CXCR2 in GBM CSCs (S6); Tumor vascularization was not affected by siRNA-knockdown of IL-8 in CSCs (S7).
Supplementary Figure Legend from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche
Authors: Infanger David W. , Cho YouJin , Lopez Brina S. , Mohanan Sunish , Liu S. Chris , Gursel Demirkan , Boockvar John A. , Fischbach Claudia
Published: March 2023

PDF file - 26K
Supplementary Materials and Methods from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: March 2023

PDF file - 116KB
Supplementary Figure Legends from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: March 2023

PDF file - 107KB
Supplementary Figure Legend from EGFR-TKI Resistance Due to BIM Polymorphism Can Be Circumvented in Combination with HDAC Inhibition
Authors: Nakagawa Takayuki , Takeuchi Shinji , Yamada Tadaaki , Ebi Hiromichi , Sano Takako , Nanjo Shigeki , Ishikawa Daisuke , Sato Mitsuo , Hasegawa Yoshinori , Sekido Yoshitaka , Yano Seiji
Published: March 2023

PDF file - 89K
Supplementary Methods, Figure Legend from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: March 2023

PDF file - 91K
Supplementary Figure 3 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL
Authors: Zhou Zheng-Jun , Dai Zhi , Zhou Shao-Lai , Hu Zhi-Qiang , Chen Qing , Zhao Yi-Ming , Shi Ying-Hong , Gao Qiang , Wu Wei-Zhong , Qiu Shuang-Jian , Zhou Jian , Fan Jia
Published: March 2023

PDF file - 844K, Supplementary Figure S3. Snail is critical for hnRNPAB-dependent regulation of E-cadherin expression.
Supplementary Figure 1 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL
Authors: Zhou Zheng-Jun , Dai Zhi , Zhou Shao-Lai , Hu Zhi-Qiang , Chen Qing , Zhao Yi-Ming , Shi Ying-Hong , Gao Qiang , Wu Wei-Zhong , Qiu Shuang-Jian , Zhou Jian , Fan Jia
Published: March 2023

PDF file - 964K, Supplementary Figure S1. The hnRNPAB expression in HCC cells and HCC samples.
Supplementary Figure 8 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: March 2023

PDF file - 80K, A model explaining the role of deltaNp63 expression in tumor initiation and tumor growth.
Supplementary Figure 7 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: March 2023

PDF file - 143K, Cell cycle analysis.
Supplementary Table 4 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: March 2023

PDF file - 51KB, Human protein sequence homologies for IGFBP-2 C-terminus.
Supplementary Figures 1 - 4 from Dual Functions of the Homeoprotein DLX4 in Modulating Responsiveness of Tumor Cells to Topoisomerase II-Targeting Drugs
Authors: Trinh Bon Q. , Ko Song Yi , Barengo Nicolas , Lin Shiaw-Yih , Naora Honami
Published: March 2023

PDF file - 444K, S1 TOP2A transcript levels in ovarian and lung cancers stratified by DLX4 expression. S2 Overexpression and knockdown of TOP2. S3 DLX4 does not stimulate HR-mediated repair of DSBs. S4 DLX4 increases the magnitude of erroneous end-joining repair of DSBs.
Supplementary Figure Legends from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: March 2023

PDF file - 68K
Supplementary Methods from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: March 2023

PDF file - 99K, Materials and methods of CytoCy5S synthesis, purification, spectral and structural characterization in addition to NTR/CytoCy5S enzymatic reaction conditions and western blots.
Supplementary Figure Legend from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Authors: Munir Shamaila , Andersen Gitte Holmen , Met Özcan , Donia Marco , Frøsig Thomas Mørch , Larsen Stine Kiaer , Klausen Tobias Wirenfeldt , Svane Inge Marie , Andersen Mads Hald
Published: March 2023

PDF file - 88K
Supplementary Figure 3 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: March 2023

PDF file - 98K, Supplemental Figure 3. Lucigenin chemiluminescence assay for superoxide detection performed as described in materials and methods on a) isolated membrane fractions from parental 786-0, RCC4 and Caki-1 cells or isolated cell fractions from 786-0 (b) or RCC4 (c) cells. RLU: relative light units.
Supplementary Tables 1-3 from Chromosome Instability Modulated by BMI1–AURKA Signaling Drives Progression in Head and Neck Cancer
Authors: Chou Chun-Hung , Yang Neng-Kai , Liu Ting-Yun , Tai Shyh-Kuan , Hsu Dennis Shin-Shian , Chen Ya-Wei , Chen Yann-Jang , Chang Cheng-Chi , Tzeng Cheng-Hwai , Yang Muh-Hwa
Published: March 2023

PDF file - 95KB, Sequence of the oligonucleotides for shRNA construct-making, reverse transcription, real-time PCR, and ChIP assay (S1); List of proteins tested by antibodies and characteristics of the corresponding antibodies (S2); Expression profile of microRNAs in FaDu-Bmi1 versus FaDu-cDNA3 (S3)
Supplementary Figure 6 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: March 2023

PDF file - 981K, Fig. S6: Inhibition of pAkt mediates AS101's activity involving chemotherapy-induced AML cell death as tested by subG1 accumulation.
Supplementary Figure 4 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: March 2023

PDF file - 251K, Discriminating chronotoxicity Classes based on selected circadian mRNA gene expressions in liver and colon mucosa.
Supplementary Figure 1 from Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells
Authors: Luo Wei , Yu Wei-Dong , Ma Yingyu , Chernov Mikhail , Trump Donald L. , Johnson Candace S.
Published: March 2023

PDF file - 2596K, CYP24A1 mRNA expression in PC3 cell treated with TBBz and 1,25D3
Supplementary Figure 3 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: March 2023

PDF file - 517K, iNGR binding is not mediated by alphav integrins
Supplementary Figures 1 - 6 from Phenotypic Profiling of DPYD Variations Relevant to 5-Fluorouracil Sensitivity Using Real-time Cellular Analysis and In Vitro Measurement of Enzyme Activity
Authors: Offer Steven M. , Wegner Natalie J. , Fossum Croix , Wang Kangsheng , Diasio Robert B.
Published: March 2023

PDF file - 497K, Supplementary Figures: 1. Determining the range of linear response for DPD expression and enzyme activity. 2. Analysis of CI profiles using a single analysis time. 3. Establishment of measurement times independently for each culture. 4. Comparison of slope at the toxicity time point. 5. Comparison of slope at the recovery time point. 6. Location of amino acids 534 and 543 within the 5-FU binding pocket of DPD.
Supplementary Methods from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Authors: Chow Kin-Hoe , Shin Dong-Mi , Jenkins Molly H. , Miller Emily E. , Shih David J. , Choi Seungbum , Low Benjamin E. , Philip Vivek , Rybinski Brad , Bronson Roderick T. , Taylor Michael D. , Yun Kyuson
Published: March 2023

Supplementary Methods
Supplementary Table 1 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

PDF file - 45K, Evaluation of metastasis properties of S2-013 cells following orthotopic implantation of cell lines re-expressing different p120 catenin isoforms with and without overexpression of MUC1.
Supplementary Figure 5 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Authors: Chow Kin-Hoe , Shin Dong-Mi , Jenkins Molly H. , Miller Emily E. , Shih David J. , Choi Seungbum , Low Benjamin E. , Philip Vivek , Rybinski Brad , Bronson Roderick T. , Taylor Michael D. , Yun Kyuson
Published: March 2023

IPA analysis.
Supplementary Movie 3 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

MOV file - 2621K, Motility S2-013.3A
Data Supplement from ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Authors: Lin Chen-Yuan , Chen Hung-Jen , Huang Cheng-Chung , Lai Liang-Chuan , Lu Tzu-Pin , Tseng Guan-Chin , Kuo Ting-Ting , Kuok Qian-Yu , Hsu Jennifer L. , Sung Shian-Ying , Hung Mien-Chie , Sher Yuh-Pyng
Published: March 2023

Supplementary Figure S1. Characterization of parental (F4), brain-metastatic (Bm7) and ADAM9 knockdown lung cancer cell lines.