bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotional Dysregulation in Preschool Age Predicts Later Media Use and Gaming Disorder Symptoms in Childhood
Authors: Paulus Frank W. , Hübler Karen , Mink Fabienne , Möhler Eva
Published: June 2021

Background: The aim of this study was to evaluate the role of early Emotional Dysregulation (ED) at preschool age as a risk factor or predictor of later media use behavior and Gaming Disorder (GD) in school age.

Methods: 80 patients (63.7% male; mean age = 4.2, SD = 1.23) who had attended a special outpatient program for preschoolers at measuring point time t1 were contacted at measuring point time t2 (mean age = 9.2, SD = 2.03). At t1, the comprehensive clinical assessment comprised Child Behavior Checklist—Dysregulation Profile (CBCL-DP). At t2, parents completed a questionnaire on their children's media availability, usage times, and GD.

Results: ED predicts a more intense use of digital media in the future. The daily average screen-use time at t2 varies significantly between the groups (148 min for children with ED at t1 and 85 min for children without ED at t1). The intensity of media use can be considered a significant predictor for the presence of a GD in dimensional assessment. When GD is classified categorically, according to the DSM-5 criteria, there is no significant correlation between ED and later GD diagnosis, neither between screen-use time and GD diagnosis. However, at dimensional level, preschool children with ED show significantly higher GD symptom scores at 9 years of age.

Conclusion: ED at preschool age is strongly associated with time spent video gaming and GD symptoms 5 years later. Our results strongly indicate that emotion dysregulation in preschool children is a risk factor for later problematic video game playing behavior. This strengthens the concept of ED in the etiology of media use and provides potential targets for early GD prevention.
Link Between Topographic Memory and the Combined Presentation of ADHD (ADHD-C): A Pilot Study
Authors: Faedda Noemi , Guariglia Cecilia , Piccardi Laura , Natalucci Giulia , Rossetti Serena , Baglioni Valentina , Alunni Fegatelli Danilo , Romani Maria , Vigliante Miriam , Guidetti Vincenzo
Published: June 2021

Background: Topographic memory is the ability to reach various places by recognizing spatial layouts and getting oriented in familiar environments. It involves several different cognitive abilities, in particular executive functions (EF), such as attention, working memory, and planning. Children with attention deficit hyperactivity disorder (ADHD) show impairments in inhibitory control, regulation of attention, planning, and working memory.

Aim: The aim of this study was to evaluate the topographic memory in children with ADHD-combined subtype (ADHD-C).

Method: Fifteen children (8–10 years) with a diagnosis of ADHD-C (DSM-5) (ADHD-C group) were compared to 15 children with typical development (TD group) of the same age. All children performed Raven's colored progressive matrices (CPM) test to obtain a measure related with cognitive functioning. The walking Corsi test (WalCT), a large-scale version of the Corsi block-tapping test, was used to assess topographic memory in experimental environment.

Results: A higher impairment was observed in ADHD-C than TD with significant differences in the WalCT, in particular on the topographic short-term memory (TSTM) task, on the topographic learning (TL) task, and on the repetition number (RN) task during the TL task. Perseverative errors were reported in performing the square-sequence in the WalCT. Zero-order correlations showed a positive correlation between TSTM and auditory attention, and memory of design of NEPSY-II and digit span of WISC-IV. No statistically significant differences were found between the ADHD-C group and TD group in the TL task in the WalCT condition.

Conclusion: In ADHD-C, initial topographic learning was compromised whereas the long-term retention of learned topographical material seemed to not be impaired. In particular, these impairments seem to be linked with difficulties in sustained attention, in spatial memory for novel visual materials, in a poor working memory, and in perseverative behaviors.
Effect of Methylphenidate on Resting-State Connectivity in Adolescents With a Disruptive Behavior Disorder: A Double-Blind Randomized Placebo-Controlled fMRI Study
Authors: Pape Louise , van Lith Koen , Veltman Dick , Cohn Moran , Marhe Reshmi , van den Brink Wim , Doreleijers Theo , Popma Arne
Published: June 2021

Some studies suggest that methylphenidate (MPH) might be an effective treatment for antisocial and aggressive behavior in adolescence. However, little is known about the mechanism of action of MPH in adolescents with this kind of psychopathology. MPH is a dopamine and norepinephrine reuptake inhibitor and thus it is likely to affect dopaminergic mesocorticolimbic pathways. This is the first study to investigate the effect of MPH on resting-state connectivity of three mesolimbic seed regions with the rest of the brain in clinical referred male adolescents with a disruptive behavior disorder (DBD). Thirty-six male DBD adolescents and 31 male healthy controls (HCs) were included. DBD subjects were randomly allocated to a single dose of MPH (DBD-MPH, n = 20) or placebo (DBD-PCB, n = 16). Seed-based resting-state functional connectivity of the nucleus accumbens (NAcc), amygdala, and ventral tegmental area (VTA) with the rest of the brain was compared between groups. The NAcc seed showed increased connectivity in DBD-PCB compared to HC with the occipital cortex, posterior cingulate cortex (PCC), precuneus, and inferior parietal lobule (IPL) and increased connectivity in DBD-PCB compared to DBD-MPH with occipital cortex, IPL, and medial frontal gyrus. The amygdala seed showed increased connectivity in DBD-PCB compared to HC with the precuneus and PCC. The VTA seed showed increased connectivity in the DBD-MPH compared to the DBD-PCB group with a cluster in the postcentral gyrus and a cluster in the supplementary motor cortex/superior frontal gyrus. Both NAcc and amygdala seeds showed no connectivity differences in the DBD-MPH compared to the HC group, indicating that MPH normalizes the increased functional connectivity of mesolimbic seed regions with areas involved in moral decision making, visual processing, and attention.
Facebook Intrusion as a Mediator Between Positive Capital and General Distress: A Cross-Cultural Study
Authors: Przepiórka Aneta , Błachnio Agata , Sullman Mark , Gorbaniuk Oleg , Siu Nicolson Yat-Fan , Hill Tetiana , Gras Maria-Eugenia , Kagialis Antonios , Lisun Yanina , Díaz-Peñaloza Maité , Manrique-Millones Denisse , Nikiforou Militsa , Evtina Galina S. , Taylor Joanne E. , Tekes Burcu , Šeibokaite Laura , Wundersitz Lisa , Calvo Fran , Font-Mayolas Sílvia
Published: June 2021

Background: Social networking sites (SNSs) play an important role in many aspects of life nowadays, and it seems to be crucial to explore their impact on human well-being and functioning. The main aim of the study was to examine the mediating role of Facebook intrusion between positive capital and general distress. Positive capital was considered as comprising self-esteem, ego-resiliency, and self-control, while general distress was seen as having three dimensions: depression, anxiety, and stress.

Methods: The sample consisted of N = 4,495 participants (M = 22.96 years, SD = 5.46) from 14 countries: Australia, Cyprus, Greece, Hong Kong, Lithuania, New Zealand, Peru, Poland, Russia, Spain, Turkey, Ukraine, United Kingdom, and United States. We used the following methods: the Facebook Intrusion Questionnaire (FIQ), the Self-Esteem Scale (SES), the Brief Self-Control Scale (SCS), The Ego Resiliency Revised Scale and the Depression, Anxiety, and Stress Scale-21 (DASS-21).

Results: We found that Facebook intrusion was a mediator between self-esteem and general distress and between self-control and general distress.

Limitations: The present study was based on a cross-sectional study, and the measures used were self-report measures. The majority of the participants were recruited using convenience sampling.

Conclusions: The present findings contribute to a better understanding on how the social media have impact on individual mental health. Implications for future studies are discussed.
Policy Implementation Science to Advance Population Health: The Potential for Learning Health Policy Systems
Authors: Oh April , Abazeed Ali , Chambers David A.
Published: June 2021

Many health policies are designed with the intention of improving health outcomes for all. Yet implementation of policies are variable across contexts, potentially limiting its impact on population health outcomes. The potential impact of a policy to advance health equity depends both on the design and its implementation, requiring ongoing evaluation and stakeholder engagement. Despite the importance of health policies in shaping public health, health care policy implementation science remains underrepresented in research. We argue that enhanced integration of policy questions within implementation science could reduce the time lag from policy to practice and improve population health outcomes to build a body of evidence on effective policy implementation. In this commentary, we argue that approaches to studying policy implementation science should reflect the dynamic and evolving policy context, analogous to the “learning healthcare system,” to better understand and respond to systematic and multilevel impacts of policy. Several example opportunities for a learning health policy system are posed in building a broader agenda toward research and practice in policy implementation science in public health.
A Low-Complexity Reconfigurable Multi-Antenna Technique for Non-Terrestrial Networks
Authors: Maliatsos Konstantinos , Bithas Petros S. , Kanatas Athanasios G.
Published: June 2021

Multi-Antenna communication techniques are an efficient and relatively simple approach for the performance improvement of wireless communication systems. However, the direct application of multi-antenna techniques to an aerial communication system is not always feasible due to the constraints induced by the aerial platforms. Reconfigurable intelligent antenna technologies could provide an efficient solution to these problems and thus they are considered as ideal candidates for adaption in the aerial communication platforms that will be used in the 5G and beyond communication networks. In this paper, a joint Tx-Rx beamforming with beam selection and combining technique is proposed for improving the performance of an aerial communication system supported by electronically steerable antenna arrays. The main idea of the proposed scheme is to select, using an SNR maximization criterion, a pair of beam patterns between each RF chain of the ground station and the aerial platform, and combine the received SNRs under the maximal ratio principle. Initially, an analytical stochastic framework has been developed that is based on a Markov chain model, which is used to investigate the statistics of the received SNR. Then, an implementation of the novel beamforming and pattern adaptation scheme is presented, with the use of Electronically Steerable Parasitic Array Radiators (ESPAR), properly designed for Ground Station to UAV links. In addition, a realistic simulator is also developed with proper channel model selection, by the aid of which, the performance of the proposed scheme has been evaluated in conjunction with the extracted analytical results.
Onshoring Through Automation; Perpetuating Inequality?
Authors: Studley Matthew
Published: June 2021

Many analyses of the ethical, legal and societal impacts of robotics are focussed on Europe and the United States. In this article I discuss the impacts of robotics on developing nations in a connected world, and make the case that international equity demands that we extend the scope of our discussions around these impacts. Offshoring has been instrumental in the economic development of a series of nations. As technology advances and wage share increases, less labour is required to achieve the same task, and more job functions move to new areas with lower labour costs. This cascade results in a ladder of economic betterment that is footed in a succession of countries, and has improved standards of living and human flourishing. The recent international crisis precipitated by COVID-19 has underlined the vulnerability of many industries to disruptions in global supply chains. As a response to this, “onshoring” of functions which had been moved to other nations decreases risk, but would increase labour costs if it were not for automation. Robotics, by facilitating onshoring, risks pulling up the ladder, and suppressing the drivers for economic development. The roots of the economic disparities that motivate these international shifts lie in many cases in colonialism and its effects on colonised societies. As we discuss the colonial legacy, and being mindful of the justifications and rationale for distributive justice, we should consider how robotics impacts international development.
Clustering Esports Gameplay Consumers via Game Experiences
Authors: Jang Wooyoung William , Byon Kevin K. , Pecoraro Jennifer , Tsuji Yosuke
Published: June 2021

This study focuses on “game experiences” in the context of esports gameplay consumption and aims to identify adequate consumer groups based on their esports experience including perceptions of gameplay, watching, and purchasing hardware. The purpose of this study is to identify adequate consumer groups through consumer segmentation. Based on the literature review, a matrix of esports gameplay was proposed based on high/low esports gameplay, viewing esports, and hardware enthusiasm. Four esports gameplay consumer groups are proposed (all-around gamer, conventional player, observer, recreational gamer) based on their prior esports experiences (esports gameplay, viewing esports content via media, and hardware enthusiasm). A total of 699 usable observations were initially collected by the online survey. Eventually, 508 observations were retained (127 for each group) for multivariate analysis of variance and subsequent univariate tests. The findings indicated the four esports gameplay consumer groups were empirically supported. Furthermore, this study found similarities and differences for each group based on the six antecedents of esports gameplay intention. The findings indicated hedonic motivation and price value might be considered general factors that may be applied to all esports consumers. Contrarily, the findings indicated that social influence, habit, effort expectancy, and flow might be suitable for tailored marketing strategies targeting esports consumer groups. Theoretically, the suggested esports experience will contribute to the growing body of knowledge aimed at understanding esports consumers' behavior through the consistent clustering of behavioral prior experience. Practically, the proposed esports consumers' clustering will contribute to more efficient marketing, with spending on more targeted marketing leading to effectively reaching the right people.
Elucidating Pathways and Discourses Linking Cocoa Cultivation to Deforestation, Reforestation, and Tree Cover Change in Nicaragua and Peru
Authors: Orozco-Aguilar Luis , López-Sampson Arlene , Leandro-Muñoz Mariela E. , Robiglio Valentina , Reyes Martin , Bordeaux Melanie , Sepúlveda Norvin , Somarriba Eduardo
Published: June 2021

Cocoa cultivation is labeled as a driver of both deforestation and reforestation, yet the extent of the phenomena varies at farm and landscape level and as a response to national and local contexts. In this study, we documented the main pathways and contexts behind cocoa cultivation in two sites with different histories of cocoa cultivation. We combined official statistics, land-use trajectory, satellite imagery, and the Q-analysis to explore the discourses of country experts in Nicaragua and Peru. The Q-statements were based on an analysis of a set of legal, institutional, social, and technical guidelines that the cocoa cultivation/sector influences or is influenced by. Based on the responses of national experts to 31 statements we found four discourses linking cocoa cultivation and reforestation and deforestation in each country-case study. The enabling and limiting conditions driving tree cover change were a combination of landscape configuration, governance, management/commercialization models, and farmer's knowledge. Overall, between 60 and 64% of the variance was explained by four discourse factors in each country. In Nicaragua, the conditions associated with reforestation were the cocoa-agroforestry model promoted by local organizations/NGOs, the existence of incentives, degree of technical knowledge, access to safe market, and availability of improved genetic material. The circumstances associated with deforestation were the age of the farmers, fluctuation of cocoa beans prices, low productivity of cocoa plantations, and weak legal environmental frameworks. Whereas, in Peru, the main factors connecting cocoa cultivation to reforestation were access to market, degree of experimentation in cocoa, the economic weight of cocoa on family's income, certification processes, the existence of incentives, and the level of organization/association of cocoa farmers. The elements linking cocoa farming to deforestation were the influence of stakeholders in the cocoa value chain, weak legal environmental frameworks, fluctuation of cocoa prices, the existence of private investors, and insecure land tenure rights. This article demonstrated the utility of discourse analysis, through its application to two contrasting country case-studies, to elucidate the conditions that might minimize the deforestation footprint of cocoa cultivation and maximize its role as an agent for reforestation/restoration in the agricultural landscape of cocoa-growing areas in Latin America.
Spinal Cord Diffuse Midline Glioma With Histone H3 K27M Mutation in a Pediatric Patient
Authors: Cheng Ran , Li Da-Peng , Zhang Nan , Zhang Ji-Yin , Zhang Di , Liu Ting-Ting , Yang Jun , Ge Ming
Published: June 2021

Background: Diffuse midline glioma (DMG) with histone H3 K27M mutation is a recently identified entity documented in the 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System. Spinal cord DMGs with H3 K27M-mutant are commonly reported in adults. Herein, we reported a pediatric patient with spinal cord H3 K27M-mutant DMG.

Case Report: A 7-year-old girl with 1-month history of neck pain and 3-week history of progressive weakness in the right hand was presented. Spinal magnetic resonance imaging showed an intramedullary lesion with slight enhancement at the C2-7 levels. With intraoperative neuroelectrophysiological monitoring, the lesion was subtotally resected. Histopathological examination revealed a DMG with histone H3 K27M mutation corresponding to WHO grade IV. Postoperatively, the neck pain was relieved, and the upper-extremity weakness remained unchanged. Oral temozolomide was administrated for 7 months, and radiotherapy was performed for 22 courses. After an 18-month follow-up, no tumor recurrence was noted.

Conclusion: Spinal cord H3 K27M-mutant DMGs are extremely rare in pediatric patients. Preoperative differential diagnosis is challenging, and surgical resection with postoperative chemoradiotherapy may be an effective treatment.
Assessing Service-Learning in Community-Based Veterinary Medicine as a Pedagogical Approach to Promoting Student Confidence in Addressing Access to Veterinary Care
Authors: King Erin , Mueller Megan , Wolfus Gregory , McCobb Emily
Published: June 2021

Community-based veterinary medicine is a growing field, and veterinary students need to be able to work with clients facing complex barriers to receiving veterinary care for their pet. Many veterinary clients experience challenges accessing veterinary care due to financial limitations, transportation access, language comprehension, the ability to comply to the care plan (e.g., disabilities, physical, or mental health challenges, substance use), the ability to come to the clinic during the hours that it is open, and the ability to communicate outside of the appointment. The goal of this study was to assess student confidence levels working in accessible care before and after participating in a service-learning-based community veterinary rotation. Results show significantly higher student confidence levels for every barrier after completing the Tufts at Tech (TAT) Clinical Rotation at Cummings Veterinary School of Medicine. Additionally, 86% (n = 85) of students strongly agreed or agreed that TAT affected their thoughts about community medicine, and 77% (n = 76) strongly agreed or agreed that the rotation affected their feelings about underserved clients. Service-learning rotations in community-based veterinary medicine could be one pedagogical approach in training veterinary students to work with a diverse clientele.
Penicillin Treatment Failure in Rabbit Syphilis Due to the Persistence of Treponemes (Treponema paraluisleporidarum Ecovar Cuniculus) in the Focus of Infection
Authors: Jekl Vladimír , Nováková Markéta , Jeklová Edita , Pospíšilová Petra , Křenová Jitka , Faldyna Martin , Škorič Miša , Šmajs David
Published: June 2021

Rabbit venereal spirochetosis, a disease caused by Treponema paraluisleporidarum ecovar Cuniculus (TPeC), affects both wild and pet rabbits, and is transmitted sexually and via direct contact among animals. Treatment of syphilis in pet rabbits requires administration of antibiotics, including penicillin G, chloramphenicol, or fluoroquinolones. The aim of this work was to elucidate the cause of penicillin treatment failure in rabbit syphilis in a pet rabbit treated in Brno, Czech Republic, and to assess the phylogenetic relatedness of the agent to previously characterized pathogenic treponemes. Following amputation of the infected digits, the second round of penicillin treatment using the same dosage and application route resulted in the disappearance of clinical symptoms within a period of two weeks. The bacterium was successfully isolated from the claws, propagated in three experimental rabbits, and the resulting TPeC strain was designated as Cz-2020. Analysis of four genetic loci revealed that the Cz-2020 strain was similar but also clearly distinct from the only TPeC strain, which had been characterized in detail to date, i.e., the Cuniculi A strain, which was isolated in North America. The strain Cz-2020 represents the first available viable TPeC strain of European origin. DNA sequences encoding five penicillin-binding proteins of the strain Cz-2020 were compared to those of Cuniculi A, which is known to be sensitive to penicillin. The sequences differed in six nucleotides resulting in single amino acid changes in Penicillin-binding protein 1, 2, and 3. Since the second round of treatment was successful, we conclude that the penicillin treatment failure in the first round resulted from the presence of infection foci in claws where treponemes persisted.
Enhanced Ruminal Fermentation Parameters and Altered Rumen Bacterial Community Composition by Formulated Rumen Buffer Agents Fed to Dairy Cows with a High-Concentrate Diet
Authors: Ramos Sonny C. , Jeong Chang-Dae , Mamuad Lovelia L. , Kim Seon-Ho , Son A-Rang , Miguel Michelle A. , Islam Mahfuzul , Cho Yong-Il , Lee Sang-Suk
Published: June 2021

The effects of rumen buffer agents on ruminal fermentation parameters and bacterial community composition were determined using in vitro and in vivo experiments in three rumen-cannulated, high-concentrate fed Holstein Friesian dairy cows. Experiment 1 in vitro treatments included bentonite, calcium carbonate, calcium oxide, sodium bicarbonate, sodium sesquicarbonate, and processed coral, and unbuffered samples served as the control. Experiment 2 in vitro treatments were based on the formulation of various combinations of the buffer agents used in Experiment 1. Combinations were selected for the in vivo study based on their buffering ability. Calcium oxide, sodium bicarbonate, and sodium sesquicarbonate stabilized the ruminal pH and improved in vitro rumen fermentation. The combined buffer agents had a significant effect on pH, buffering capacity, total gas, and total volatile fatty acids. Firmicutes and Bacteroidetes were the dominant phyla in both treatments and the control. Ruminococcus and Prevotella were found to be the dominant genera. Ruminococcus bromii was predominant in the treatment group. Prevotella jejuni was more abundant in the control group compared to the treatment group, in which its abundance was very low. Ruminococcus flavefaciens and Intestinimonas butyriciproducens gradually increased in abundance as cows received treatment. Overall, a high-concentrate diet administered to cows induced adverse changes in ruminal pH; however, buffer supplementation enhanced ruminal fermentation characteristics and altered bacterial community, which could contribute to preventing ruminal acidosis.
Increasing Dietary Potassium Chloride Promotes Urine Dilution and Decreases Calcium Oxalate Relative Supersaturation in Healthy Dogs and Cats
Authors: Bijsmans Esther , Quéau Yann , Biourge Vincent
Published: June 2021

Urine dilution is a strategy used to decrease the risk of crystallization in cats and dogs at risk of urolithiasis. Sodium chloride has been used in prescription diets to effectively promote urine dilution, but the effect of the salt-substitute potassium chloride (KCl) on urine parameters has not been extensively investigated. Two diets differing only in KCl (Diet A; K 0.44 g/MJ, Diet B; K 1.03 g/MJ) were fed to 17 cats and 22 dogs for seven days, followed by three days of urine collection. Urinary ion concentrations were determined by ionic chromatography, and SUPERSAT software was used to calculate the relative supersaturation (RSS) value for struvite and calcium oxalate. Water intake and urine volume increased, and USG decreased on diet B (p < 0.001). Urine concentration of potassium increased on diet B, but concentrations of all other ions did not change or decrease in line with urine dilution. Calcium oxalate RSS decreased on diet B (p < 0.05). This short-term study showed that increased dietary KCl in a dry extruded diet effectively dilutes the urine of cats and dogs and therefore offers a novel nutritional strategy for the prevention of urolithiasis. This finding is of interest for patients that would benefit from dietary sodium restriction.
In Vitro Evaluation of the Potential Pharmacological Activity and Molecular Targets of New Benzimidazole-Based Schiff Base Metal Complexes
Authors: Aragón-Muriel Alberto , Liscano Yamil , Upegui Yulieth , Robledo Sara M. , Ramírez-Apan María Teresa , Morales-Morales David , Oñate-Garzón Jose , Polo-Cerón Dorian
Published: June 2021

Metal-based drugs, including lanthanide complexes, have been extremely effective in clinical treatments against various diseases and have raised major interest in recent decades. Hence, in this work, a series of lanthanum (III) and cerium (III) complexes, including Schiff base ligands derived from (1H-benzimidazol-2-yl)aniline, salicylaldehyde, and 2,4-dihydroxybenzaldehyde were synthesized and characterized using different spectroscopic methods. Besides their cytotoxic activities, they were examined in human U-937 cells, primate kidney non-cancerous COS-7, and six other, different human tumor cell lines: U251, PC-3, K562, HCT-15, MCF-7, and SK-LU-1. In addition, the synthesized compounds were screened for in vitro antiparasitic activity against Leishmania braziliensis, Plasmodium falciparum, and Trypanosoma cruzi. Additionally, antibacterial activities were examined against two Gram-positive strains (S. aureus ATCC® 25923, L. monocytogenes ATCC® 19115) and two Gram-negative strains (E. coli ATCC® 25922, P. aeruginosa ATCC® 27583) using the microdilution method. The lanthanide complexes generally exhibited increased biological activity compared with the free Schiff base ligands. Interactions between the tested compounds and model membranes were examined using differential scanning calorimetry (DSC), and interactions with calf thymus DNA (CT-DNA) were investigated by ultraviolet (UV) absorption. Molecular docking studies were performed using leishmanin (1LML), cruzain (4PI3), P. falciparum alpha-tubulin (GenBank sequence CAA34101 [453 aa]), and S.aureus penicillin-binding protein 2a (PBP2A; 5M18) as the protein receptors. The results lead to the conclusion that the synthesized compounds exhibited a notable effect on model membranes imitating mammalian and bacterial membranes and rolled along DNA strands through groove interactions. Interactions between the compounds and studied receptors depended primarily on ligand structures in the molecular docking study.
Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
Authors: Cárdenas-Rodríguez Noemí , Bandala Cindy , Vanoye-Carlo América , Ignacio-Mejía Iván , Gómez-Manzo Saúl , Hernández-Cruz Estefani Yaquelin , Pedraza-Chaverri José , Carmona-Aparicio Liliana , Hernández-Ochoa Beatriz
Published: June 2021

Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is an emergent infectious disease that has caused millions of deaths throughout the world. COVID-19 infection’s main symptoms are fever, cough, fatigue, and neurological manifestations such as headache, myalgias, anosmia, ageusia, impaired consciousness, seizures, and even neuromuscular junctions’ disorders. In addition, it is known that this disease causes a series of systemic complications such as adverse respiratory distress syndrome, cardiac injury, acute kidney injury, and liver dysfunction. Due to the neurological symptoms associated with COVID-19, damage in the central nervous system has been suggested as well as the neuroinvasive potential of SARS-CoV-2. It is known that CoV infections are associated with an inflammation process related to the imbalance of the antioxidant system; cellular changes caused by oxidative stress contribute to brain tissue damage. Although anti-COVID-19 vaccines are under development, there is no specific treatment for COVID-19 and its clinical manifestations and complications; only supportive treatments with immunomodulators, anti-vascular endothelial growth factors, modulating drugs, statins, or nutritional supplements have been used. In the present work, we analyzed the potential of antioxidants as adjuvants for the treatment of COVID-19 and specifically their possible role in preventing or decreasing the neurological manifestations and neurological complications present in the disease.
Security of Blockchain-Based Supply Chain Management Systems: Challenges and Opportunities
Authors: Al-Farsi Sana , Rathore Muhammad Mazhar , Bakiras Spiros
Published: June 2021

Blockchain is a revolutionary technology that is being used in many applications, including supply chain management. Although, the primary motive of using a blockchain for supply chain management is to reduce the overall production cost while providing the comprehensive security to the system. However, current blockchain-based supply-chain management (BC-SCM) systems still hold the possibility of cyber attacks. Therefore, the goal of this study is to investigate practical threats and vulnerabilities in the design of BC-SCM systems. As a starting point, we first establish key requirements for the reliability and security of supply chain management systems, i.e., transparency, privacy and traceability, and then discern a threat model that includes two distinctive but practical threats including computational (i.e., the ones that threaten the functionality of the application) and communication (i.e., the ones that threaten information exchange among interconnected services of the application). For investigation, we follow a unique approach based on the hypothesis that reliability is pre-requisite of security and identify the threats considering (i) design of smart contracts and associated supply chain management applications, (ii) underlying blockchain execution environment and (iii) trust between all interconnected supply management services. Moreover, we consider both academic and industry solutions to identify the threats. We identify several challenges that hinder to establish reliability and security of the BC-SCM systems. Importantly, we also highlight research gaps that can help to establish desired security of the BC-SCM. To the best of our knowledge, this paper is the first effort that identifies practical threats to blockchain-based supply chain management systems and provides their counter measures. Finally, this work establishes foundation for future investigation towards practical security of BC-SCM system.
Adaptive Data Augmentation to Achieve Noise Robustness and Overcome Data Deficiency for Deep Learning
Authors: Kim Eunkyeong , Kim Jinyong , Lee Hansoo , Kim Sungshin
Published: June 2021

Artificial intelligence technologies and robot vision systems are core technologies in smart factories. Currently, there is scholarly interest in automatic data feature extraction in smart factories using deep learning networks. However, sufficient training data are required to train these networks. In addition, barely perceptible noise can affect classification accuracy. Therefore, to increase the amount of training data and achieve robustness against noise attacks, a data augmentation method implemented using the adaptive inverse peak signal-to-noise ratio was developed in this study to consider the influence of the color characteristics of the training images. This method was used to automatically determine the optimal perturbation range of the color perturbation method for generating images using weights based on the characteristics of the training images. The experimental results showed that the proposed method could generate new training images from original images, classify noisy images with greater accuracy, and generally improve the classification accuracy. This demonstrates that the proposed method is effective and robust to noise, even when the training data are deficient.
The Cost of Energy-Efficiency in Digital Hardware: The Trade-Off between Energy Dissipation, Energy–Delay Product and Reliability in Electronic, Magnetic and Optical Binary Switches
Authors: Rahman Rahnuma , Bandyopadhyay Supriyo
Published: June 2021

Binary switches, which are the primitive units of all digital computing and information processing hardware, are usually benchmarked on the basis of their ‘energy–delay product’, which is the product of the energy dissipated in completing the switching action and the time it takes to complete that action. The lower the energy–delay product, the better the switch (supposedly). This approach ignores the fact that lower energy dissipation and faster switching usually come at the cost of poorer reliability (i.e., a higher switching error rate) and hence the energy–delay product alone cannot be a good metric for benchmarking switches. Here, we show the trade-off between energy dissipation, energy–delay product and error–probability for an electronic switch (a metal oxide semiconductor field effect transistor), a magnetic switch (a magnetic tunnel junction switched with spin transfer torque) and an optical switch (bistable non-linear mirror). As expected, reducing energy dissipation and/or energy–delay product generally results in increased switching error probability and reduced reliability.
Innovative Biotechnology for Generation of Cardiac Tissue
Authors: Barbulescu Greta Ionela , Bojin Florina Maria , Ordodi Valentin Laurentiu , Goje Iacob Daniel , Buica Taddeus Paul , Gavriliuc Oana Isabella , Baderca Flavia , Hoinoiu Teodora , Paunescu Virgil
Published: June 2021

Heart transplantation remains the only curative treatment for end-stage heart failure. This life-saving option continues to be limited by the low number of organ donors, graft rejection and adverse effects of immunosuppressants. Engineering bioartificial hearts from acellular native-derived scaffolds and stem cells has gained attention because of its potential to overcome these limitations. In this study, rat hearts (n = 20) were decellularized by means of coronary perfusion with 1% sodium dodecyl sulfate (SDS) in a modified Langendorff device. The electrical field behavior of the SDS molecule was studied and it was assumed that when applying an alternating current, the exposure time of the tissue to the detergent might decrease. To repopulate the decellularized extracellular matrix (ECM), human mesenchymal stem cells (hMSCs) were used, induced to differentiate into cardiomyocytes (CMs) with 5-azacytidine (5-aza). The results showed no cellular debris and an intact ECM following decellularization. Decellularization in the presence of an electric field proved to be faster, decreasing the potential risk of ECM damage due to the detergent. After cell seeding and culturing of eight scaffolds with hMSCs, the recellularization process was analyzed using optic microscopy (OM), which showed cells suggestive for CMs. This study presents a novel and efficient decellularization protocol using an electric field and suggests that hMSCs can be useful in the generation of a bioartificial heart.
Current Perspectives on the Role of Matrix Metalloproteinases in the Pathogenesis of Basal Cell Carcinoma
Authors: Tampa Mircea , Georgescu Simona Roxana , Mitran Madalina Irina , Mitran Cristina Iulia , Matei Clara , Caruntu Ana , Scheau Cristian , Nicolae Ilinca , Matei Andreea , Caruntu Constantin , Constantin Carolina , Neagu Monica
Published: June 2021

Basal cell carcinoma (BCC) is the most common skin malignancy, which rarely metastasizes but has a great ability to infiltrate and invade the surrounding tissues. One of the molecular players involved in the metastatic process are matrix metalloproteinases (MMPs). MMPs are enzymes that can degrade various components of the extracellular matrix. In the skin, the expression of MMPs is increased in response to various stimuli, including ultraviolet (UV) radiation, one of the main factors involved in the development of BCC. By modulating various processes that are linked to tumor growth, such as invasion and angiogenesis, MMPs have been associated with UV-related carcinogenesis. The sources of MMPs are multiple, as they can be released by both neoplastic and tumor microenvironment cells. Inhibiting the action of MMPs could be a useful therapeutic option in BCC management. In this review that reunites the latest advances in this domain, we discuss the role of MMPs in the pathogenesis and evolution of BCC, as molecules involved in tumor aggressiveness and risk of recurrence, in order to offer a fresh and updated perspective on this field.
Influence of Pain and Discomfort in Stroke Patients on Coping Strategies and Changes in Behavior and Lifestyle
Authors: Reverté-Villarroya Silvia , Suñer-Soler Rosa , Font-Mayolas Sílvia , Dávalos Errando Antonio , Sauras-Colón Esther , Gras-Navarro Andrea , Adell-Lleixà Mireia , Casanova-Garrigós Georgina , Gil-Mateu Elsa , Berenguer-Poblet Marta
Published: June 2021

The implementation of prevention strategies can reduce the risk of having a stroke. This prospective, longitudinal, multicenter observational study of 82 patients describes health habits, quality of life, coping strategies, and physical and neurological status at 3 months and 1 year after stroke. The EuroQoL-5D quality of life scale (EQ-5D) and the coping strategy measurement scale (COPE-28) were used to assess pain and discomfort, and behavioral and lifestyle changes. Significant differences were observed in the pain or discomfort levels of those patients with behavioral and lifestyle changes. Correlation was also found between pain or discomfort and the coping strategies associated with active emotional support at 1 year after stroke. The results of the pain or discomfort dimension were not, however, associated with better adherence to treatment. Pain and discomfort could have a predictive value in changes in lifestyles and behaviors but not for treatment adherence in patients who have had a stroke, which is significant at 1 year. In addition to important active coping strategies such as social support, these changes in behavior and lifestyle following a stroke are long-term and should therefore be assessed during the initial examination.
Energy-Efficient Retrofit Measures (EERM) in Residential Buildings: An Application of Discrete Choice Modelling
Authors: Camarasa Clara , Kalahasthi Lokesh Kumar , Sanchez-Díaz Ivan , Rosado Leonardo , Hennes Lena , Bienge Katrin , Hamilton Ian
Published: June 2021

Cross-country evidence on the adoption of energy-efficient retrofit measures (EERMs) in residential buildings is critical to supporting the development of national and pan-European policies aimed at fostering the energy performance upgrade of the building stock. In this light, the aim of this paper is to advance in the understanding of the probability of certain EERMs taking place in eight EU countries, according to a set of parameters, such as building typology, project types, and motivation behind the project. Using these parameters collected via a multi-country online survey, a set of discrete-choice (conditional logit) models are estimated on the probability of selecting a choice of any combination of 33 EERMs across the sampled countries. Results show that actions related to the building envelope are the most often-addressed across countries and single building elements or technology measures have a higher probability of being implemented. The modelling framework developed in this study contributes to the scientific community in three ways: (1) establishing an empirical relationship among EERMs and project (i.e., retrofit and deep retrofit), (2) identifying commonalities and differences across the selected countries, and (3) quantifying the probabilities and market shares of various EERMs.
Familial Risk and Heritability of Hematologic Malignancies in the Nordic Twin Study of Cancer
Authors: Clemmensen Signe B. , Harris Jennifer R. , Mengel-From Jonas , Bonat Wagner H. , Frederiksen Henrik , Kaprio Jaakko , Hjelmborg Jacob v. B.
Published: June 2021

We aimed to explore the genetic and environmental contributions to variation in the risk of hematologic malignancies and characterize familial dependence within and across hematologic malignancies. The study base included 316,397 individual twins from the Nordic Twin Study of Cancer with a median of 41 years of follow-up: 88,618 (28%) of the twins were monozygotic, and 3459 hematologic malignancies were reported. We estimated the cumulative incidence by age, familial risk, and genetic and environmental variance components of hematologic malignancies accounting for competing risk of death. The lifetime risk of any hematologic malignancy was 2.5% (95% CI 2.4–2.6%), as in the background population. This risk was elevated to 4.5% (95% CI 3.1–6.5%) conditional on hematologic malignancy in a dizygotic co-twin and was even greater at 7.6% (95% CI 4.8–11.8%) if a monozygotic co-twin had a hematologic malignancy. Heritability of the liability to develop any hematologic malignancy was 24% (95% CI 14–33%). This estimate decreased across age, from approximately 55% at age 40 to about 20–25% after age 55, when it seems to stabilize. In this largest ever studied twin cohort with the longest follow-up, we found evidence for familial risk of hematologic malignancies. The discovery of decreasing familial predisposition with increasing age underscores the importance of cancer surveillance in families with hematological malignancies.
New Trends in Esophageal Cancer Management
Authors: Gronnier Caroline , Collet Denis
Published: June 2021

Esophageal cancer (EC) is a condition with a five-year survival rate of around 15% for all stages considered [...]
Exploring the Stability of Fe–Ni Alloy Nanoparticles Exsolved from Double-Layered Perovskites for Dry Reforming of Methane
Authors: Carrillo Alfonso J. , Serra José Manuel
Published: June 2021

Exsolution is emerging as a promising route for the creation of nanoparticles that remain anchored to the oxide support, imparting remarkable stability in high temperature chemical processes such as dry reforming of methane. This process takes place at temperatures around 850 °C, which causes sintering-related issues in catalysts prepared using conventional impregnation methods, which could be overcome by using exsolution functionalized oxides. In this work, FeNi3 alloy nanoparticles exsolved from Sr2FexNi1-xMoO6-δ double-layered perovskites were evaluated as a dry reforming catalyst, paying special attention to structure–activity relationships. Our results indicate that increasing the Ni content favors the nanoparticle dispersion, eventually leading to increased CO2 and CH4 conversions. The exsolved nanoparticles presented remarkable nanoparticle size (ca. 30 nm) stability after the 10 h treatment, although the formation of some phase segregations over the course of the reaction caused a minor decrease in the nanoparticle population. Overall, the results presented here serve as materials processing guidelines that could find further potential use in the design of more efficient (electro)catalysts in other fuel production or energy conversion technologies.
Synthesis of Gd2O3 Nanoparticles and Their Photocatalytic Activity for Degradation of Azo Dyes
Authors: Jeon Sugyeong , Ko Jeong-Won , Ko Weon-Bae
Published: June 2021

Gadolinium oxide (Gd2O3) nanoparticles were prepared via the reaction of gadolinium nitrate hexahydrate (Gd (NO3)3·6H2O) and ethylamine (C2H5NH2), and their surface morphology, particle size, and properties were examined by using scanning electron microscopy, X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, and ultraviolet visible (UV-vis) spectroscopy. The Gd2O3 nanoparticles were used as the photocatalyst for the degradation of various azo dyes, such as methyl orange (MO), acid orange 7 (AO7), and acid yellow 23 (AY23) under irradiation with UV light. The effect of the experimental parameters (initial concentration of azo dyes, dosage of catalyst, and wavelength of UV light) on the photocatalytic properties of the Gd2O3 nanoparticles were investigated. At a constant H2O2 concentration, the photocatalytic degradation efficiency of the Gd2O3 nanoparticles for various azo dyes was in the order: methyl orange > acid orange 7 > acid yellow 23. The kinetics study showed that the photocatalytic degradation of azo dyes was followed by a pseudo first-order reaction rate law.
Fetal Fractures in an Infant with Maternal Ehlers-Danlos Syndrome, CCDC134 Pathogenic Mutation and a Negative Genetic Test for Osteogenesis Imperfecta
Authors: Holick Michael F. , Shirvani Arash , Charoenngam Nipith
Published: June 2021

Intrauterine fractures are a rare clinical finding caused by abnormal early-life osteogenesis. In this case report, we reported a male infant with twenty-three intrauterine/fetal fractures resembling osteogenesis imperfecta and tested negative for COL1A1 and COL1A2 mutations. The infant’s mother had Ehlers–Danlos syndrome, hypermobility type. Whole-genome sequencing revealed that there were no pathologic mutations previously documented to be associated with intrauterine fracture. Genetic mutations reported to be associated with fragility fractures were identified. These include the pathogenic homozygous mutation in the CCDC134 gene. Other genetic variants that might be responsible for variable expressivity of the skeletal manifestation include the homozygous variants of the genes CCDC134, COL15A1 and ZFPM1, and the heterozygous variants of the genes MYH3, BCHE, AUTS2. This is the first reported case of in utero fractures, that was confirmed by X-ray after birth, in an infant who had no genetic evidence for osteogenesis imperfecta, had a homozygous pathogenic mutation of an osteogenesis gene and whose mother had Ehlers-Danlos syndrome hypermobility type. Therefore, we have identified a new genetic cause for in utero fractures. If after birth, this infant were found to have these fractures in various stages of healing with a negative genetic test for osteogenesis imperfecta he would have been misdiagnosed as due to nonaccidental trauma.