bluuebunny/crossref_metadata_2025 huggingface dataset:
Active tolerance development in allergy to cow-based milk proteins
Authors: Galimova Albina A. , Vyazankina Svetlana S. , Makarova Svetlana G. , Ereshko Oksana A.
Published: December 2021

Food allergy is a potentially life-threatening condition without approved pathogenetic treatments other than eliminating the causal allergen and relief of acute allergic conditions. Immunoglobulin G-mediated form of food allergy remains a serious and growing problem worldwide. Its prevalence is steadily increasing and is a severe psychosocial and economic burden for patients and their families. Cow-based milk and products are important components of a childs diet, which are introduced at their first year of life, which can cause allergic reactions. The traditional management of children with cow-based milk allergy includes eliminating the dairy-free diet, and a significant number of patients form milk protein tolerance by the age of 5 years. However, with persistent forms of allergy to cow-based milk proteins, the need for active tactics of patient management to form tolerance arises. Oral immunotherapy is a promising approach to food allergy treatments based on a gradually increased allergen by analogy with standardized immunotherapy for respiratory allergens until reaching a maintenance dose. Each stage of oral immunotherapy should be considered as a personalized therapy.
This review contains an analysis of available studies on the effectiveness of oral immunotherapy in the treatment of cow-based milk protein allergy.
NUTRITION OF YOUNG LEMON PLANTS IN THE OPEN FIELD
Authors: Sultonov Kamolitdin Sadriddinovich  , Nortojiev Bobosher Sheralievich  , Yusupova Kamola Qosimovna
Published: December 2021

The article provides scientific data on the study of optimal norms and timing of leaf feeding in the care of young lemon seedlings in the open field. The care of young lemon seedlings in the open field focuses on the rapid growth of branches, enlargement of leaf surface and leaf activity. Due to the additional nutrition of the leaves, the growth and development of young lemon seedlings is accelerated, the leaf surface is cleaned of dust, which has a positive effect on the metabolism of the leaves, the process of respiration and photosynthesis in the leaves. As a result, young lemon seedlings grow well in the short term and are formed as seedlings ready for planting in the main area.
KEYWORDS: lemon, seedling, seedling, twig, leaf surface, open area, air temperature, relative humidity, fertilizer, suspension, photosynthesis.
ТRAINING MATHEMATICS TEACHERS FOR THE IMPLEMENTATION OF BLENDED LEARNING IN GENERAL EDUCATION ORGANIZATION
Authors: Derbush M.V. , Skarbich S.N.
Published: December 2021

Professional training of mathematics teachers presupposes continuous professional development in connection with the introduction of innovative teaching technologies into educational practice, which include blended learning. The article presents the components that determine the training of teachers for the implementation of various models of blended learning in mathematics with a description of the content of each of them. An approximate program of advanced training courses, which has a modular structure, is presented. The criteria for the readiness of mathematics teachers to implement blended learning in accordance with the selected components are indicated.
REFLECTION AS A METHOD OF PROFESSIONAL SELF-ASSESSMENT IN THE SYSTEM OF CHOREOGRAPHIC EDUCATION
Authors: Sabantseva T.V.
Published: December 2021

The article defines the concept of reflexive analysis in choreographic education. The classification of reflexive analysis is specified. A step-by-step algorithm of reflexive analysis in the educational process of choreographer students has been developed. The results of its practical application in preparation for intermediate and final certification in the disciplines of the professional block of the educational program confirmed the effectiveness of thoughtful and organized reflection.
PHILOSOPHICAL STATUS OF ARTISTIC AVANT-GARDE
Authors: Krasnoyarova N.G.
Published: December 2021

The article asserts the exhaustion of art criticism and culturological approaches to the artistic avant-garde. The context of the philosophy of culture as an actual section of philosophy makes it possible to reveal the essential moments of culture as a whole in the artistic avant-garde and to manifest the function of the avant-garde as a special “new phenomenon” imparting dynamism to culture in ways of accepting or rejecting cultural values.
ABSTRACTING IN ENGLISH: FROM THE PROBLEM OF TRANSLATION TO THE PROBLEM OF TEACHING
Authors: Aydanova Yu.F.
Published: December 2021

The article discusses the development of students’ skills in writing research activities in English. The author considers the most popular genre of scientific style — the abstract. The theoretical substantiation of the problem of polysemy of scientific style words is presented. A set of practical tasks aimed at forming abstract writing and translation skills is proposed.
EQUIVALENCE PRESERVATION IN CONVEYING THE MEANING OF THE PASSIVE VOICE CATEGORY FROM RUSSIAN TO CHINESE (A CASE STUDY OF WEBSITES OF MINSK TRACTOR PLANT AND GREAT STONE INDUSTRIAL PARK)
Authors: Gibkij P.V. , Suprunchuk N.V.
Published: December 2021

The article is devoted to the problem of equivalence preservation in translation from Russian into Chinese. In the course of our work, we identified the ways and degree of preservation of translation equivalence at the fourth level according to V. N. Komissarov when conveying voice meanings, comparing the Chinese version of the website of Minsk Tractor Plant with the original version.
LINGUISTIC REPRESENTATION OF THE ‘SCIENTIST’S SPIRIT’ IMAGE IN CHINESE AND RUSSIAN MEDIA DISCOURSES (EXAMPLIFIED BY NEWS ARTICLES)
Authors: Morgun V.G.
Published: December 2021

The article provides a comprehensive study of the mechanism of functioning of language tools in the process of text formation, and presents the results of studying the image of the ‘scientist’s spirit’ in modern media discourse on the example of Chinese and Russian news articles. The analysis of empirical material has shown that when representing the spirit of a scientist, general (epithet, metaphor, hyperbole/litotes, lexical repetition, syntactic parallelism, gradation, homogeneous parts of the sentence, parenthetic constructions) and particular for Chinese media discourse (comparison, inversion, parcellation, question-and-answer form of presentation) linguistic means prevail.
FEMINITIVES AS AN OBJECT OF DISCUSSION IN SOCIAL NETWORK VKONTAKTE (A CASE STUDY OF GROUPS VK.COM/KNIFE.MEDIA AND VK.COM/SYSBLOK)
Authors: Rogozhnikova T.P. , Meloyan T.Kh.
Published: December 2021

The subbject for the study is the vocabulary used by subscribers of groups on the VKontakte social network “System Block” and “Knife Magazine” in posts on the topic of feminism. The article considers the nominations of women by profession and occupation (feminitives), semantically motivated and stylistically marked vocabulary, as well as all violations and deviations from the literary norm. The opposition of groups according to the degree of normalization of the speech behavior of users was recorded, a high degree of normality and deviation towards slang, borrowings or vernacular were revealed.
Використання САПР у проектуванні систем автоматизації.
Authors: Троянчук Б. , Федік Л.
Published: December 2021

У статті визначено і досліджено актуальні системи автоматизованого проектування. А також проаналізовано існуючі CAD системи і спрогнозовано розвиток ринку в цій сфері. Викладено особливості проектування систем автоматизації в програмах AutoCAD, Solidworks, LibreCAD, MagiCAD, ZWCAD.
Нейронна мережа для діагностики хвороби Паркінсона за зображенням спіралі Архімеда.
Authors: Харченко Н. , Сердаковський В.
Published: December 2021

У статті розглянуто актуальну проблему встановлення діагнозу Паркінсона на ранніх стадіях захворювання.    Вибір теми дослідження обумовлено невиліковністю хвороби Паркінсона, отже  вкрай гостро,  на думку авторів є   нагальне виявлення захворювання на ранніх стадіях. Констатовано, що діагностики, для точного встановлення діагнозу нині не існує, тому залишається проведення тестів для виявлення симптомів. Одним з таких, як слушно зауважують автори є малювання спіралі Архімеда, яке має доволі високу точність під час виявлення тремору спокою. Створення алгоритму для автоматичної обробки таких зображень може допомогти у проведені діагностики, а також моніторингу розвитку хвороби. Поєднання штучного інтелекту та інтернет медичних речей з часом зробить підключені пристрої для моніторингу стану здоров’я більш інтелектуальними. Нейронні мережі та величезні обсяги даних, що генеруються інтернет медичних речей, також можуть використовуватися для встановлення діагнозу. Авторами  статті  наголошено на фундаментальних  можливостях нейронних мереж, їх  сприятливій ролі у  трансформації сфери радіології,  шляхом заощадження часу та грошей медичних організацій.   Розроблено нейронну мережу, яка зможе за зображенням намальованої спіралі Архімеда встановити діагноз. Дану мережу можна використовувати для проведення ранньої діагностики, а також подальшого моніторингу стану хвороби. Зважаючи на невелику вибірку зображень для навчання та тренування моделі  авторами  статті було прийняте рішення про збільшення вибірки шляхом перетворення зображень, а також використання згорткової нейронної мережі з попереднім навчанням. У результаті проведеної роботи було створено модель, яка має точність 93.7 відсотків яка дозволить автоматизувати процес діагностики хвороби на ранніх стадіях.
Порівняння властивості засвоєння семантичних зв’язків між словами природної мови моделями методу Word2Vec у задачі аналізу настроїв.
Authors: Гарбузенко О. , П’ятикоп О.
Published: December 2021

Дана робота присвячена дослідженню ефективного визначення настрою англомовних постів з соціальних мереж, що базується на перетворенні слів у векторні представлення за допомогою методу Word2Vec. У роботі описані та проаналізовані існуючі методи сентимент аналізу, проаналізовано моделі Continuous Bag of Words (CBOW) та Skip-gram у складі методу Word2Vec, проведено порівняння їх властивостей при засвоєнні семантичних зв’язків між словами природної мови. Описано експериментальне дослідження щодо використання зазначених моделей при різних функціях тренування.
Towards the Feasibility of Instituting a Philippine Digital Audio Library: A Case Study
Authors: Li Jia
Published: December 2021

As a spearhead force in music research, especially in the area of South East Asia region, the University of the Philippines (UP) Center for Ethnomusicology (UPCE) caters to a gigantic collection of audio materials which covers different musics and musical traditions in the Philippines, South East Asia and representative areas from other continents. As an outcome of its former appellation, the “UP Ethnomusicology Archives”, UPCE hosts an ethnomusicological collection of about 2500 hours of recorded music in open reel and cassette tape formats, under the authorship of Jose Maceda whose visionary work of putting together these valuable recorded materials left a treasure for ethnomusicology scholarship and research. In recognition of his influential contribution that made the UCPE an archive and repository of materials on music, philosophy, anthropology and other cognate disciplines, these audio materials, together with field notes, music transcriptions, song texts, photographs, music instruments, music compositions, personal files, about 200 books and journals, all of which he personally initiated and developed as a unified institution resource for music research are called “Jose Maceda Collection”.
Review on Dark Web and Its Impact on Internet Governance
Authors: Rajamanickam Diviya Shini , Zolkipli Mohamad Fadli
Published: December 2021

Cyber attackers use the Dark Web, a collection of facilities that are not visible to search engines and normal users, to explore a variety of illegal products and services. In this paper, the Dark Web and its impact on internet governance were analyzed. The findings of a review of the literature provide in-depth knowledge on the increasing number of crimes committed on the Dark Web, considering the economic, social, along ethical consequences of cybercrime on the Dark Web, as well as analyzing the consequences and methods for locating the criminals, as well as their drawbacks. Fraudsters, militants, and government-sponsored secret agents used the Dark Web where is among the most popular difficult together with unidentifiable channels to achieve their illicit goals. Crimes that were committed on the Dark Web are similar to criminal offenses committed in the real world. Nevertheless, the sheer size of the Dark Web, the unpredictability of the ecosystem, as well as the privacy and confidentiality afforded by Dark Web services, were also critical challenges in tracing criminals. Measuring the yachting Dark Web crime risks is a critical step in discovering alternative approaches to cybercrime. The study reveals that Dark Web services are available to arrest criminals, as well as digital facts and evidence, should be analyzed and applied in a way that allows Internet Governance.
Effect of Scratch Programming Language (SPL) on Achievement in Geometry among Senior Secondary Students in Ibadan, Nigeria
Authors: Akinyemi Adetunmbi Laolu , Ogundipe Tomi , Adelana Owolabi Paul
Published: December 2021

The knowledge of Mathematics is germane to the scientific and technological development of nations all over the world. In addition to this, the integration of Information and Communication Technology (ICT) cum advances in pedagogy have made educators all over the world adopt innovative approaches that are ICT-inclined to enhance students’ acquisition of mathematical skills and also to enhance their academic achievement. In view of this, this study determined the effect of scratch programming language (SPL) on achievement in Geometry among senior secondary one (SS 1) students in Ibadan North Local Government Area of Oyo State, Nigeria. The study adopted the pretest-posttest control group quasi-experimental research design. The participants were 116 (75 males and 41 females) Senior Secondary School students in two intact classes from two public schools in Ibadan North Local Government Area. The instruments used for data collection were the Students Achievement Test in Geometry (SATG) (with a reliability coefficient of 0.75) and the Instructional Guide or Manual for the use of Scratch Programming Language (TGUSPL). Data were analyzed using Analysis of Covariance (ANCOVA). Results revealed that there was a significant main effect of treatment on students’ achievement in Geometry (F(1, 111) = 124.80; p<0.05, partial η2 = 0.53). Gender also had a significant main effect on students’ achievement in Geometry (F(1, 111) = 20.25; p<0.05, partial η2 = 0.15). It is, therefore, recommended that teachers and curriculum developers should adopt the use of Scratch programming language (SPL) for teaching Geometry for improved achievement in this aspect of Mathematics.
A Conceptual Proposal for Mobile Learning Interactive Courseware for Basic French-Malay
Authors: Mohamad Haris Nur Aina Sakinah , Ariffin Shamsul Arrieya
Published: December 2021

In this study, an interactive mobile learning web-based system will be developed, 'Basic French-Malay Words,' especially for the first-timer students taking French subjects in schools or universities. The development of this system is to learn the difficulties of the Malay tongue students to understand French as a foreign language using existing conventional methods. Therefore, to overcome this problem, the first objective of this research is to identify the system's criteria that will be a suitable platform to learn. Next is developing a mobile learning web-based system that will help students overcome the arising problems. The last objective is to evaluate students' and educators' satisfaction via the usability of the application. Hence, this study is intended to design and develop a mobile web-based system for students to learn French in the Malay language. The methodology used for identifying the requirements is from the literature review content analysis and interviews. The software development uses Waterfall Model, and the technique for software evaluation uses heuristic evaluation. In conclusion, the expected result will be the requirements, software prototype, and level of user satisfaction in using this mobile learning web-based system. Therefore, this article presents the conceptual proposal for this research.
Photo-Degradation of Orange G as an Environmental Pollutant with TiO2-ZnO Composite Material
Authors: Md Abdullah Bin Samad  , Md. Amjad Hossain  , Tajmeri S. A. Islam  , Waziha Farha
Published: December 2021

The increasing water pollution is a great concern as millions of people don't have access to pure water in Bangladesh. A considerable number of people are dying of contaminated water each year not only in Bangladesh but all over the world. Many industries, tanneries, companies, etc. are emitting lots of environmentally hazardous materials into the surrounding water. Many of these pollutants are industrial dyes. The dyes loss from the industrial water during dyeing operation damage the esthetic merit of surface water. They minimize light penetration, hamper aquatic lives and hinder photosynthesis. Some dyes may also have toxic, mutagenic, and carcinogenic characteristics. The purpose of this research is to get rid of the pollutant dye Orange G before the water is contaminated. A method named photo-degradation using different light sources is used to mineralize Orange G dye with composite materials including TiO2-ZnO. This composite was prepared by the hydrothermal method. The photocatalytic behavior of the prepared composite TiO2-ZnO helps in minimizing the effect of this dye to save the water from contamination. The composite compoundwas studied by experimenting on photo-degradation with Orange G under different light sources such as visible light, UV light, and sunlight. The photo-degradation percentage was found to maximum of 79.60 in the presence of sunlight. The percentages of photo-degradation under UV light and visible light were 48.0 and 18.40 respectively.
Overview and Management of Chronic Kidney Disease Inpatients at Royal Prima General Hospital Medan in 2020
Authors: Armika Yuke , Nerseri Barus
Published: December 2021

Chronic kidney disease (CKD) is a condition in which there is a gradual decline in kidney function. This disease is progressive and usually irreversible. Indications for hospitalized CKD patients with severe complications and do not allow inpatient therapy. This study was aimed to describe the overview and management of chronic kidney disease inpatient in Royal Prima General Hospital Medan. The type of research used is research with a descriptive and retrospective case study design. This study is based on medical record data related to inpatient CKD patients' diagnostic and management features at the Royal Prima General Hospital Medan in 2020. The research subjects were all inpatients diagnosed with CKD, whereas 100 research subjects with complete medical records were included in this study. It was found that the highest age group was 57-65 years, as much as 37.0%, and men as much as 27%. The chief complaint was shortness of breath at 43% and additional complaints, the most of which were fever + low back pain + edema at 38%. On physical examination, most of the inspections were weak, 55%. Most palpation was sociable 57%. There was auscultation of four abdominal regions and normal positive bowel sounds (93%). Complete blood count + blood sugar level + electrolytes + urea + creatinine 70%, the most combination medication is NaCl 0.9% + Furosemide injection 31%. Based on the length of stay, the longest was 13-14 days (20%).
Overview of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients at Royal Prima Hospital Medan Indonesia
Authors: Riski N. Situmeang  , Sopacua Erwin
Published: December 2021

Diabetes Mellitus (DM) is a chronic disease characterized by blood glucose (blood sugar) levels exceeding normal. Diabetic nephropathy is a chronic microvascular complication that often occurs in diabetics. This study presents a picture of diabetic nephropathy in type 2 DM patients at the Royal Prima Hospital in Medan. This research is a type of descriptive research. The sample from this study was the total data of patients suffering from diabetic nephropathy who met the inclusion and exclusion criteria at Royal Prima Hospital from January 1, 2020 – to December 31, 2020. The inclusion criteria for the subjects of this study were complete patient medical records, type 2 diabetes patients, urinalysis tests. (proteinuria ≥ +2), renal function examination exceeds normal values, blood urea, and creatinine. The mean age of diabetic nephropathy patients was 57.52 years and the majority were 62 men (50.8%). The average picture of urea levels in diabetic nephropathy patients is 51.8 and the average creatinine level is 1.48. The majority of patients with diabetic nephropathy do not have proteinuria. And the average blood sugar level is 267 mg/dL. In conclusion, the incidence of diabetic nephropathy is highest in patients aged 57 years. The mean value of urea level is 51.80 mg/dl, creatinine value is 1.48 mg/dl, and the average blood sugar level is 267 mg/dl. Most proteinuria was in the negative category of as many as 107 people (87%).
ТЕОРЕТИКО-МЕТОДОЛОГІЧНІ ЗАСАДИ ПСИХОЛОГІЧНОГО ПРОЕКТУВАННЯ, РОЗВИТКУ, САМОЗДІЙСНЕННЯ ОСОБИСТОСТІ ДИТИНИ: МАЙБУТНЄ НАЦІЇ НЕОБХІДНО ВИРОЩУВАТИ
Authors: Maksymenko Serhii
Published: December 2021

У сучасних умовах розвитку суспільства конкурентоздатною є креативна особистість дитини, яка здійснює творчу діяльність, саморозвивається. Розкрито можливі шляхи розвитку особистості дитини через призму генетичної психології, зокрема, генетико-креативного підходу. Представлено основні механізми творчості. Наукове дослідження психології особистості як дійсного (а не уявного лише) предмету вивчення, як унікальної, неповторної і цілісної системи, єдності, є одним із вагомих напрямів у цифровізації. Сучасна наука не має головного — методу, який був би адекватним цьому предмету. Метод виступає центральною ланкою всієї проблеми психології особистості, оскільки він є не лише засобом отримання наукових емпіричних фактів, а й засобом втілення наукового знання та способом його існування і зберігання. Мета генетичної психології людини — вивчити умови, у яких процес перетворення змісту і форм власних психічних явищ, станів свідомості і способів дій зможе досягти такого рівня досконалості психічних механізмів діяльності, на якому виникає здатність робити відкриття чи винаходи, створювати художні образи.
REVISITING CHOISE OF A STRATEGY FOR RUSSIAN LEGAL SPACE DEVELOPMENT
Authors: Чупилкина Айгуль Фаридовна
Published: December 2021

Автор, принимая во внимание выделяемые философами древности необходимые условия (факторы) государственного самосохранения, отмечает, что самой важной целью государства является не его собственное сохранение, а сохранение его главного ресурса - человека. Поскольку право - это регулятор (по определению) и индикатор происходящих в государстве событий, веяний (по В. О. Ключевскому), автор рассматривает один из самых тревожащих юридическое сообщество вопросов законодательной (прежде всего конституционной) перестройки - вопрос о наделении роботов правосубъектностью, что приравнивает статус робота к статусу человека. В связи с этим рассмотрены следующие вопросы: 1) необходимость стабильности для жизни людей, а следовательно, для жизни государства; 2) закон человеческого вырождения; 3) нахождение государственных законов внутри природных законов. Сделаны выводы, которые необходимо принять при разработке стратегии российского правового пространства. Знание и сохранение внутреннего равновесия (природной гармонии) - это необходимость, без которой не выживет человечество в целом.

The author takes into account the warnings of ancient philosophers to deduce the necessary conditions (factors) of state self-preservation. But the most important goal of the state is not only its own preservation, but the preservation of its main resource - man. Since law is a regulator (by definition) and an indicator of events and trends taking place in the state (according to V. O. Klyuchevsky), the author considers one of the most disturbing symptoms of legislative (primarily constitutional) restructuring for the legal community - the issue of granting robots legal personality, which equates the status of a robot with the status of a person. In this connection, the following issues were considered: 1) the need for stability for the life of people, and therefore for the life of the state; 2) the law of human degeneration; 3) the finding of state laws within natural laws. The conclusions that need to be taken when developing a strategy for the Russian legal space are drawn. Knowledge and preservation of internal balance (natural harmony) is a necessity, without which humanity as a whole will not survive.
COUNTERING CRIMINAL INCULTURATION OF CONVICTS IN DETENTION FACILITIES AS AN INDEPENDENT DIRECTION OF PENAL OFFICERS`ACTIVITY: NEW APPROACHES
Authors: Брежнева Ксения Валерьевна
Published: December 2021

В статье анализируется важность обучения сотрудников уголовно-исполнительной системы основам противодействия криминальной субкультуре в целях профилактики ее негативного распространения преступниками-профессионалами среди осужденных, грамотного противодействия рецидивистам и реализации качественной воспитательной работы с осужденными. Автор вносит ряд предложений: ввести в ведомственных вузах правоохранительной системы в качестве самостоятельного спецкурса дисциплину «Основы противодействия криминальной инкультурации в местах лишения свободы»; совершенствовать институт «шефства» над молодыми сотрудниками, а также курсы первоначальной подготовки и повышения квалификации. Воспитательная работа с осужденными не перестает нуждаться в особом внимании. Следует внедрять новые формы, методы и приемы воспитательной работы с осужденными или совершенствовать уже имеющиеся. Автор подчеркивает, что в современных условиях для эффективного осуществления служебной деятельности в дополнение к строгому соблюдению прав, запретов и обязанностей, содержащихся в ПВР, каждому сотруднику УИС следует применять профессиональную смекалку в общении с осужденными, которая была бы направлена, главным образом, на стимулирование их внутриличностных изменений в положительную сторону.

The article analyzes the importance of training employees of the penitentiary system in the basics of the criminal subculture in order to prevent its negative spread by professional criminals among convicts, competent counteraction to recidivists and implementation of high-quality educational work with convicts. The author makes a number of proposals: to introduce the discipline «Fundamentals of countering criminal inculturation in places of deprivation of liberty» in departmental universities of the law enforcement system as an independent special course; to improve the institution of «patronage» over young employees, as well as initial training and advanced training courses. Educational work with convicts does not cease to need special attention. It is necessary to introduce new forms, methods and techniques of educational work with convicts or improve existing ones. The author emphasizes that in modern conditions, apparently, it is clearly not enough to think only within the framework of the rights, prohibitions, and duties prescribed in the PVR for the performance of official activities. In addition to this, each employee of the penal institution should use professional ingenuity in communicating with convicts, which would be aimed mainly at stimulating their intrapersonal changes in a positive way.
INVESTMENT ACTIVITY OF THE REGION AS ECONOMIC CATEGORY
Authors: Гродская Галина Николаевна , Чернышева Мария Владиславовна
Published: December 2021

Устойчивое развитие социально-экономической системы субъекта РФ предполагает высокий уровень его инвестиционной активности. Однако, исследование сущности данной категории и определение ее места среди смежных понятий остается нерешенной проблемой. В статье приводится сравнительный анализ подходов российских ученых к оценке инвестиционной активности региона и рассматриваются принципы ее повышения на мезоуровне.

The sustainable development of the socio-economic system of a constituent entity of the Russian Federation presupposes a high level of its investment activity. However, the study of the essence of this category and determination of its place among related concepts remains an unsolved problem. The article provides a comparative analysis of the approaches of Russian scientists to assessing the investment activity of the region and examines the principles of its increase at the meso-level.
APPLICATION OF SOFTWARE TECHNOLOGIES TO DETECT SPEECH DISORDERS
Authors: Чуксина Виктория Олеговна , Майстренко Наталья Владимировна
Published: December 2021

В данной работе рассматриваются проблемы нарушения речи в современном мире. Для решения задачи обнаружения дефектов речи на этапе предварительной диагностики в статье предлагается использовать интеллектуальный анализ для определения есть ли у человека нарушение речи или нет.

This paper examines the problems of speech impairment in the modern world. To solve the problem of detecting speech defects at the stage of preliminary diagnostics, the article proposes to use intelligent analysis to determine whether a person has a speech impairment or not.
THE INFLUENCE OF THE INDIVIDUAL WORK ON THE STUDENT'S PROFESSIONAL MOTIVATION
Authors: Чернова Надежда Васильевна
Published: December 2021

Показана структура комплекса заданий для самостоятельной работы, представлены качественные и количественные результаты эксперимента, подчеркнуто, что изменения коснулись социальной и творческой составляющих мотивационной структуры.

The structure of the complex of tasks for independent work is shown, qualitative and quantitative results of the experiment are presented, it is emphasized that the changes affected the social and creative components of the motivational structure.
CRM SYSTEMS IN PUBLIC ADMINISTRATION AND BUSINESS PROJECTS
Authors: Тимофеева Римма Алексеевна , Иванова Дарья Владимировна
Published: December 2021

CRM-системы представляют актуальную модель взаимодействия как в государственном управлении, так и в коммерческих структурах, что особенно значимо при создании и реализации бизнес-проектов. Данные системы позволяют эффективно и рационально сблизить производителя и клиента, не отвергая дилерские сети. В этом их преимущество. Органам власти всех уровней целесообразно использовать CRM-системы при оказании услуг.

CRM systems represent an actual model of interaction both in public administration and in commercial structures, which is especially important when creating and implementing business projects. These systems make it possible to effectively and rationally bring the manufacturer and the customer closer, without rejecting dealer networks. This is their advantage. It is advisable for authorities of all levels to use CRM systems when providing services.
Joseph Schacht’s Concept of Right in Islamic Law: An Analysis
Authors: Sohail Khan  , Habib Ur Rehman
Published: December 2021

While writing about the sacred law of Islam, Joseph Schacht expresses his concerns and doubts about the origins of Islamic law calling it Muhammadan Jurisprudence. He believed that Islamic law is not a Divine law and that Prophet Muhammad (peace be upon him) had no role as a legislator. Schacht’s writings influenced many Western scholars, many of whom subscribe to his thesis. This paper discusses Schacht’s approach towards Islamic law which he calls Muhammadan jurisprudence and continues to analyze his assumption that Islamic Law does not recognize the term right, comparing it with thoughts and opinions of other scholars and mentioning evidences brought forth by both the parties.
Modern Western Critical Discourse on Seerah Sources
Authors: Samia Athar  , Feroz ud din Shah Khagga
Published: December 2021

Seerah of the Prophet falls mainly under Orientalist studies evolving from an early skeptical normative to revisionism, higher criticism, biblical literary criticism and Hagarism. This perpetual change of Western academic methodology seems to indicate their fragile and non-traditional academic approach. The Orientalists like Goldziher and Schacht have been able to transform skeptical theories considerably to the extent ‘revisionist’ theories have emerged. In this paper, a critical review of modern Western critique has been discussed while conjecturing about its lacunas at the same time.
The Representation of Local Wisdom in Short Stories: A Study in North Sumatra
Authors: Surip M , Dalimunthe S Fahmy , Daulay M Anggie J
Published: December 2021

The purpose of writing this article is to provide an analytical study of literary texts associated with the diversity of local wisdom in North Sumatra. The emergence of short story writers in North Sumatra gives a new color in carrying the wisdom of the local culture. The content of short stories loaded with cultural contents is implicitly conveyed to provide knowledge about the culture itself that begins to fade. Problems in this study include how to examine local wisdom in the short stories of North Sumatra authorship. The theory used is Cultural Theory and Literary Anthropology, which is very relevant in exploring aspects of local wisdom in the content of the short stories. Qualitative descriptive methods are used in identifying and analyzing the contents of such short stories and then interpreted in the context of related local cultural wisdom. This of course requires an objective narrative so that the explanation does not deviate from the cultural packages of North Sumatra. The results of the research obtained illustrate the strength of local wisdom that appears in the content of the North Sumatra authorship short story. Aspects of the language system, social system, livelihood system, and arts represent local wisdom from the analysis of north Sumatra's authorship short stories. These values are examined from the background and from dialogues that arise from the contents of short stories and then constructed according to the theory used.
The impact of Sofosbuvir/Velpatasvir/Voxilaprevir treatment on serum hyperglycemia in HCV infections: A Systematic Review
Authors:   School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Hung Hsuan-Yu , Chen Chung-Yu
Published: December 2021

Review question / Objective: To assess the possible cause of events, the incidence of grade 3 hyperglycemia after treating Sofosbuvir/Velpatasvir/Voxilaprevir in HCV infections. Condition being studied: Sofosbuvir, velpatasvir, and voxilaprevir (SOF/VEL/VOX) is an effective, safe rescue therapy regimen for patients have previously been treated failure. Initiating Direct-Acting Antiviral (DAA) treatment for HCV infection with diabetes have experienced hypoglycemia, it could improve insulin resistance due to clean HCV. However, some studies shown that SOF/VEL/VOX has Grade 3 hyperglycemia adverse events. This finding contradicts that other DAAs studies. Information sources: Conducting a comprehensive literature search on the pubmed, Cochrane, clinicalkey, Embase, and MEDLINE electronic databases.
Program Perhitungan RAB Pekerjaan Struktur Baja (WF BEAM) Menggunakan Bahasa Python
Authors: Melinda Ravika Nur , Ningrum Laisita Meitya , Suryabrata Ida Bagus , Dwipa Gede Swarna Bayu Artha , Sukoco Tyas Pratama
Published: December 2021

ABSTRACT

Making a budget plan in a project is often done manually which of course takes a long time to complete. In determining the budget plan, there are many types of work such as preparatory work, reinforced concrete work, and steel work, so it is quite difficult to work on. The budget plan can only be done by experts in the field, so it requires quite expensive processing costs. From the problems described above, we need a program that can simplify the calculation of the budget plan, especially in steel works (WF Beam). In this case, we created a program using the python language that needed to input some data such as rod length, number of bars, type of steel, steel prices, and work wages so that it would immediately produce a value or amount of the volume and price of a steel work that could help contractors especially steel subcontractors in calculating steel work (WF Beam).

Keywords: python, RAB, WF beam, work volume, job price.

ABSTRAK

Pembuatan rencana anggaran dan biaya dalam sebuah proyek sering dilakukan secara manual yang tentunya membutuhkan waktu yang cukup lama untuk menyelesaikannya. Dalam menentukan rencana anggaran dan biaya, ada banyak jenis pekerjaan seperti pekerjaan persiapan, pekerjaan beton bertulang, dan pekerjaan baja, sehingga cukup sulit untuk dikerjakan. Rencana anggaran dan biaya juga hanya bisa dikerjakan oleh tenaga ahli pada bidang tersebut sehingga membutuhkan biaya pengerjaan yang cukup mahal. Dari permasalahan yang sudah dijabarkan diatas maka dibutuhkan sebuah program yang dapat mempermudah perhitungan rencana anggaran dan biaya khususnya di pekerjaan baja (WF Beam). Dalam hal ini, kami membuat sebuah program menggunakan bahasa python yang perlu menginputkan beberapa data seperti panjang batang, jumlah batang, jenis baja, harga baja, dan upah pekerjaan sehingga  akan langsung menghasilkan nilai atau besaran dari volume dan harga suatu pekerjaan baja yang dapat membantu kontraktor khususnya sub kontraktor baja dalam melakukan perhitungan pekerjaan baja (WF Beam).

Kata kunci: python, RAB , WF beam, volume pekerjaan, harga pekerjaan.
Nonstandard Modeling of a Possible Blue Straggler Star, KIC 11145123
Authors: Hatta Yoshiki , Sekii Takashi , Takata Masao , Benomar Othman
Published: December 2021

Nonstandard modeling of KIC 11145123, a possible blue straggler star, has been asteroseismically carried out based on a scheme to compute stellar models with the chemical compositions in their envelopes arbitrarily modified, mimicking the effects of some interactions with other stars through which blue straggler stars are thought to be born. We have constructed a nonstandard model of the star with the following parameters: M = 1.36 M
⊙, Y
init = 0.26, Z
init = 0.002, and f
ovs = 0.027, where f
ovs is the extent of overshooting described as an exponentially decaying diffusive process. The modification is down to the depth of r/R ∼ 0.6 and the extent ΔX, which is a difference in surface hydrogen abundance between the envelope-modified and unmodified models, is 0.06. The residuals between the model and the observed frequencies are comparable with those for the previous model computed assuming standard single-star evolution, suggesting that it is possible that the star was born with a relatively ordinary initial helium abundance of ∼0.26 compared with that of the previous models (∼0.30–0.40), then experienced some modification of the chemical compositions and gained helium in the envelope. Detailed analyses of the nonstandard model have implied that the elemental diffusion in the deep radiative region of the star might be much weaker than that assumed in current stellar evolutionary calculations; we need some extra mechanisms inside the star, rendering the star a much more intriguing target to be further investigated.
Periodicity Search on X-Ray Bursts of SGR J1935+2154 Using 8.5 yr of Fermi/GBM Data
Authors: Zou Jin-Hang , Zhang Bin-Bin , Zhang Guo-Qiang , Yang Yu-Han , Shao Lang , Wang Fa-Yin
Published: December 2021

We performed a systematic search for X-ray bursts of the SGR J1935+2154 using the Fermi Gamma-ray Burst Monitor continuous data dated from 2013 January to 2021 October. Eight bursting phases, which consist of a total of 353 individual bursts, are identified. We further analyze the periodic properties of our sample using the Lomb–Scargle periodogram. The result suggests that those bursts exhibit a period of ∼238 days with a ∼63.2% duty cycle. Based on our analysis, we further predict two upcoming active windows of the X-ray bursts. Since 2021 July, the beginning date of our first prediction has been confirmed by the ongoing X-ray activities of the SGR J1935+2154.
Pluto’s Atmosphere in Plateau Phase Since 2015 from a Stellar Occultation at Devasthal
Authors: Sicardy Bruno , Ashok Nagarhalli M. , Tej Anandmayee , Pawar Ganesh , Deshmukh Shishir , Deshpande Ameya , Sharma Saurabh , Desmars Josselin , Assafin Marcelo , Ortiz Jose Luis , Benedetti-Rossi Gustavo , Braga-Ribas Felipe , Vieira-Martins Roberto , Santos-Sanz Pablo , Chand Krishan , Bhatt Bhuwan C.
Published: December 2021

A stellar occultation by Pluto was observed on 2020 June 6 with the 1.3 m and 3.6 m telescopes located at Devasthal, Nainital, India, using imaging systems in the I and H bands, respectively. From this event, we derive a surface pressure for Pluto’s atmosphere of

p

surf

=

12.23

−
0.38

+
0.65

μbar. This shows that Pluto’s atmosphere has been in a plateau phase since mid-2015, a result which is in excellent agreement with the Pluto volatile transport model of Meza et al. This value does not support the pressure decrease reported by independent teams, based on occultations observed in 2018 and 2019 by Young et al. and Arimatsu et al., respectively.
High-Glucose and Free Fatty Acid-Induced Adipocytes Generate Increasing of HMGB1 and Reduced GLUT4 Expression
Authors: Rosita Rita , Yueniwati Yuyun , Endharti Agustina Tri , Widodo Mochamad Aris
Published: December 2021

Background
High-mobility group box 1 protein (HMGB1) is released from necrotic adipocytes into the extracellular milieu as an inflammatory alarmin in obesity. Although the impact of excess nutrient on adipocytes is well known, it is not clear how specific its component drive cell-size and damaged of adipocytes, and how this relates to the risk of insulin resistance.
Objectives
The aim of this study was to determine HMGB1 level in adipocytes cultures after high glucose and/or FFA exposures and to assess GLUT4 expression. We determined cellular features of adipocytes that correlates to HMGB1 released and insulin resistance.
Methods
Differentiated adipocytes were exposed to high glucose and/or FFAs for 7 days. ELISA was performed on supernatant to assess the HMGB1 level. Total GLUT4 expression were quantified by immunofluorescense.
Results
High glucose and FFA-exposed cells have significant increase of HMGB1 level with decreased of cell size and necrotic adipocytes features.  The total GLUT4 were reduced in HG-cells (p <0,045), but not in FFA cells. Hypertrophic adipocytes (p <0.05) and slight decrease of GLUT4 expression were showed on HG+FFA exposures with no increase of HMGB1 level. There was a significant correlation between cell size and HMGB1 level (R -0,637, p < 0.026)
Conclusion
The expression level studies between high glucose, FFA, and a combination of both on adipocytes results strongly suggest that high glucose is more damaging to adipocyte compared to FFA. Nevertheless, the combination of the two causes adipocyte dysfunction with general features of adipose tissue in obesity, suggested it can be used as a hypertrophic adipocytes model to study obesity in vitro.
Role of Interferon-Gamma +874 A/T Single-Nucleotide Polymorphism and Tuberculosis Susceptibility of Pediatric Population in North Sumatera, Indonesia
Authors: Daulay Rini Savitri , Saragih Rina Amalia C. , Daulay Ridwan Muchtar , Ganie Ratna Akbari , Tann Gino , Supriyatno Bambang
Published: December 2021

BACKGROUND: Tuberculosis (TB) remains to be a leading cause of morbidity and mortality worldwide. The immune defense against Mycobacterium tuberculosis (M. tuberculosis) is complicated. Interferon gamma (IFN-g) is the main cytokine involved in the immune response of TB. To date, the role of +874 A/T single nucleotide polymorphism (SNP) and TB disease susceptibility continue to be controversial.
OBJECTIVES: The aim of this study was to investigate the role of +874 A/T SNP and TB disease susceptibility of pediatric population in North Sumatera, Indonesia
METHODS:  A case control study was conducted in Medan and Batubara, North Sumatera, Indonesia from January to December 2016. A total of 51 children with TB and 51 healthy controls were enrolled in this study. Subjects were 2 months to 14 years old age children diagnosed with TB and written informed consent from the parents or the caregivers to participate. Subjects were withdrawn from the study when immunodeficiency condition was found or suffered from other infection disease. DNA samples were obtained from all of the subjects. +874 A/T SNP was identified by performing the amplification refractory mutational system - polymerase chain reaction (ARMS-PCR) method. IFN-g levels were measured by using human enzyme-linked immunosorbent assay/ELISA. Data analysis was performed using chi square and Mann Whitney test. p value <0.05 was considered significant.
RESULTS: The result of this study reveals the presence of AA, AT and TT genotype in TB patients were 31 (60.8%), 20 (39.2%) and 0 (0%); respectively (p=0.023). Significant decreased production of IFN-g levels (p=0.042) were found in TB patients 9.41 (1.10 – 28.06) pg/ml.
CONCLUSION: Our study demonstrated significant evidence of the role of +874 A/T SNP and TB disease susceptibility of pediatric population in North Sumatera, Indonesia predominantly AA genotype. Significant decreased production of IFN-g reported among pediatric TB.
Hepatoprotective Activity of Pirdot Leaves (Saurauia vulcani Korth) Ethanol Extract in Laboratory Rats (Rattus norvegicus) and Characterization of Bioactive Compounds Using a Molecular Docking Approach
Authors: Sinaga Erlintan , Ilyas Syafruddin , Hutahaean Salomo , Sitorus Panal
Published: December 2021

AIM: The hepatoprotective activities of  bioactive compounds Pirdot were investigated in vivo and in silico.
METHODS: In this study, the completely randomized design non-factorial was experimentally to assess the value of SGPT and SGOT and twenty four adult male rats were divided into four groups : group G0, control group; group G1, a treated group received 0.1 ml sheep red blood cell; group G2, a treated group received 500 mg ethanol extract Pirdot; group G3, a group treated received 500 mg ethanol extract Pirdot and 0,1 ml sheep red blood cell. On thirty one days of treatment, the blood of all rats group were taken to value SGPT and SGOT using DiaLab kit. Furthermore, the molecular docking study was done to analyse molecular interaction that COX-2 and  TNF-α were the primary target protein of bioactive compounds of Pirdot associated with hepatoprotective activities. In addition, it tends to be the target of non-steroidal anti-inflammatory drugs such as Ibuprofen.
RESULTS: The results show SGOT and SGPT value significantly [p<0.05] decreased on Group G2 and G3. Moreover, the bioactive compounds of Pirdot, such as Pomolic acid and Ursolic acid tend to be the potential compound on liver protection. Moreover, Pomolic acid has a good binding affinity -14.6 kcal mol-1 with COX-2 Protein and the binding affinity of cis-3-O-p-hydroxycinnamoyl Ursolic acid was -15.1 kcal mol-1 associated with TNF-α Protein.
CONLUSION:  Pirdot Leaves (Saurauia vulcani Korth.)  Ethanol Extract showed Hepatoprotective activity in rats (Rattus norvegicus). Molecular docking approach showed that pomolic acid has a good binding affinity with COX-2 Protein and TNF-α Protein.