bluuebunny/crossref_metadata_2025 huggingface dataset:
In Depth Review Penguatan Branding Produk Kompi (Kompos Api) Dalam Rangka Penguatan Sustainable Development Goals (SDGs) Terkait Infrastruktur Dan Inovasi Di Desa Bocek, Kecamatan Karangploso, Kabupaten Malang
Authors: Rifan Mohamad , Jazuli A Muhamad , Nurmasari Nuraini Desty , Arimbawa Putu Adi Putra
Published: January 2025

Mayoritas penduduk Indonesia bekerja sebagai petani, namun produktivitas sektor ini semakin menurun akibat cuaca ekstrem, kebijakan pemerintah yang kurang optimal, dan dinamika pasar modern. Salah satu permasalahan utama yang dihadapi adalah menumpuknya limbah pertanian akibat gagal panen, yang menyebabkan kerugian besar bagi petani. Petani cabai di Desa Bocek memiliki dua masalah yaitu penumpukan limbah cabai dan lemahnya branding produk dari segi hukum dan ekonomi. Penguatan branding produk Kompos Api menjadi langkah strategis untuk membantu petani cabai di Desa Bocek. Penguatan ini mencakup aspek hukum dengan legalisasi produk melalui pendaftaran merek dan sertifikasi halal. Aspek Ekonomi ditekankan melalui strategi pemasaran digital, yang efektif dalam memperkenalkan produk dengan biaya rendah dan membangun brand awareness melalui komunikasi interaktif di media sosial. Program pengabdian kepada masyarakat ini bertujuan untuk mengatasi tantangan yang dihadapi oleh kelompok tani dan usaha KOMPI. Sebagai solusi, tim pengabdian Universitas Brawijaya bekerja sama dengan kelompok usaha tani KOMPI mengadakan sosialisasi dan pendampingan untuk memperkuat branding produk KOMPI dari sisi Hukum dan Ekonomi. Kegiatan ini meliputi diskusi pemberian materi dan in depth review mengenai sertifikasi halal, PIRT, NIB, dan BPOM, serta pelatihan pemasaran digital berbasis media sosial. Program ini diharapkan mampu meningkatkan kesadaran petani tentang pentingnya aspek hukum dan ekonomi dalam usaha, serta memperkuat daya saing produk di pasar.
PKM Pemberdayaan Petani Produktif Tembakau Na’us Dusun Kramat, Kecamatan Kranjingan, Kabupaten Jember
Authors: Arifin Zainol , Al-Habib Ismul Mauludin , Rohman Abd
Published: January 2025

Gabungan Kelompok Tani (GAPOKTAN) Kramat Jaya adalah kelompok petani tembakau Na’us di Desa Kramat, Kelurahan Kranjingan, Kecamatan Sumbersari, Kabupaten Jember, yang berdiri sejak 6 Juni 1996 dengan ketua Bapak Taufik Hidayat dan beranggotakan 100 petani. Saat ini, kelompok ini menghadapi permasalahan dalam kapasitas produksi ±65 ton per panen di lahan seluas 10 hektar akibat penggunaan peralatan manual dan keterbatasan tenaga kerja, yang memperlambat proses pengeringan tembakau. Program PKM ini bertujuan menciptakan kerja sama positif antara GAPOKTAN dan tim pelaksana untuk meningkatkan kapasitas produksi melalui inovasi teknologi berupa mesin perajang tembakau, mengembangkan produk baru seperti pestisida alami, serta meningkatkan keterampilan dan pengetahuan berwirausaha bagi petani. Metode pelaksanaan meliputi pelatihan, pendampingan, dan pengembangan kader petani muda yang sejalan dengan program Merdeka Belajar Kampus Merdeka (MBKM). Hasil program diharapkan dapat mempercepat proses produksi, memperluas pasar, serta memberdayakan ekonomi masyarakat Dusun Kramat. Dengan keberhasilan implementasi alat perajang, pelatihan berkelanjutan, dan diversifikasi produk, GAPOKTAN Kramat Jaya dapat menjadi model pemberdayaan petani di wilayah tersebut.
DUKUNGAN SOSIAL TEMAN SEBAYA DAN MOTIVASI BELAJAR DENGAN SCHOOL WELL-BEING PADA SISWA SMP
Authors: Pertiwi Rahma Sri , Hanoum Magdalena , Purwantini Lucky
Published: January 2025

The study was conducted to determine the picture between peer social support and learning motivation with schoolwell-being at SMP Negeri 40 Bekasi City. This research method uses quantitative research with the variables studied, namely the relationship between peer social education (X1), and learning motivation (X2), towards school well-being (Y). This research was conducted at SMP Negeri 40 Bekasi City with the research subject of grade 8 students totaling 120 students, this research was conducted within a period of three months from January 16, 2023 to March 31, 2023. Data collection techniques in this study used observation, interviews and psychological measurement scales (questionnaires). The tests used in this study are descriptive tests, assumption tests, normality tests, linearity tests, correlation tests and multiple linear tests. Based on the research that has been done, it was found that there is a positive and significant relationship between peer social support and school well-being, and there is a positive and significant relationship between learning motivation and school well-being. There was an influence between peer social support and learning motivation with school well being positively and significantly with an R square value of 0.469 (46.9%) and an F Test Value of 15.962 with a significant level of p = 0.000 (ρ<0.05).
RESILIENSI DAN KEBAHAGIAAN DENGAN SOMATISASI PADA MAHASISWA TINGKAT AKHIR
Authors: Pujiarohman Pujiarohman , Astuti Indah Ayu Kusuma , Muslimah Alfiana Indah
Published: January 2025

This study aims to determine the level of somatization, resilience and happiness, to find out there is a significant relationship between resilience and happiness with somatization, and to find out there is a significant effect between resilience and happiness with somatization in finalyear students at the Islamic University "45" Bekasi. This research is a correlational quantitative research. The research subjects are final year students at the Islamic University "45" Bekasi. The number of samples is 88 people. Sampling is done by means of stratified random sampling Data collection methods in this study were interviews and psychological measurement scales. The research instrument used was the resilience scale (CD-RISC), the Happiness scale, and the somatization scale using the Likert model and the Adult Somatization Inventory (ASI). The data was obtained using a Likert scaleand processed using SPSS version 21.0. The reliability test using Cronbach's Alpha resulted inan r Alpha value = 0.949 for resilience, an r Alpha value = 0.838 for happiness, an r Alpha value = 0.963 for somatization. Data analysis using Pearson Product Moment Correlation and Multiple Linear Regression methods. The results of the analysis show that there is a negative relationship between resilience and somatization, the correlation coefficient value is -0.226 with a p-value of 0.034 (p<0.05). The results of the analysis for the second correlation are thatthere is a negative relationship between happiness and somatization, the correlation coefficientvalue is -0.230 with a p-value of 0.031 (p<0.05). These results indicate that the research hypothesis is accepted. The results of the multiple regression test between resilience (β1 = - 0.240, = 0.049 <0.05) and happiness (β2 = -0.545, = 0.028 <0.05) on somatization from the study showed that resilience had a negative and significant effect on somatization and happiness have a negative and significant influence on somatization. That is, 9.7% of resilience and happiness are influenced by these factors. While 90.3% is influenced by other variables not examined in this study.
Alucinaciones numéricas en el Arte Computacional
Authors: Sanabria Colin Miriam , Luna Vilchis Miguel Ángel
Published: January 2025

Este artículo aborda como las imágenes producto del análisis masivo de datos se caracterizan por una especie de operatividad imperativa que las instituye como modelos de acción para sus receptores. A su vez los sistemas que generan estas imágenes son sistemas contingentes que determinan el carácter informativo o redundante de estas a nivel de dato. Tomando como eje el pensamiento de teóricos como Vilém Flusser y Harun Faroky profundizaremos a que se refiere esa operatividad imperativa de la imagen tanto como superficie significativa, así como dato dentro de un proceso computacional.
Posteriormente propondremos, a partir del pensamiento de Yuk Hui, que el carácter contingente de los procesos computacionales que generan y se alimentan de estas imágenes técnicas determinan el paso de la imagen redundante a la imagen informativa, considerando esta aproximación desde la perspectiva de la arqueología de medios, es decir, considerando a la imagen desde una dimensión temporal. Finalmente abordamos desde el arte el carácter operativo imperativo y contingente informativo de la producción actual de imágenes como parte de las bases de datos que alimentan el arte computacional, para cuestionar el concepto de imagen y permitirnos proponer que éstas, más que imágenes son alucinaciones numéricas
EDUKASI PENCEGAHAN DAN PENANGANAN CEDERA SPRAIN ANKLE PADA SISWA KELAS X SMA NEGERI 11 SAMARINDA
Authors: Iskandar  , Ali Mukti , Ali Mukti , Erlita Asmi
Published: January 2025

Usia remaja masih belum bisa melakukan olahraga dengan benar seperti tidak melakukan pemanasan sebelum olahraga, tidak melakukan pendinginan setelah olahraga, tidak menggunakan sepatu yang sesuai dengan olahraganya dan lainnya, hal ini dapat mengakibatkan cedera olahraga. Cedera olahraga dapat dibagi menjadi tiga kategori yaitu cedera ringan, cedera sedang, dan cedera berat. Sprain ankle merupakan cedera yang paling sering terjadi dalam olahraga tergantung pada tingkat partipasi dalam olahraga tertentu. untuk meningkatkan pengetahuan dan pemahaman siswa-siswi SMA 11 Samarinda tentang pencegahan dan penanganan sprain ankle. Metode yang dipilih pada kegiatan Metode pada pelaksanaan penyuluhan ini yaitu pre test, ceramah, diskusi atau tanya jawab, demonstrasi atau praktek dan post test, penggunaan media proyektor (LCD) serta leaflet. Hasil pada kegiatan ini setalah dilakukan menggunakan lembar post-test dimana tingkat pemahaman meningkat dari hasil post test. Penyuluhan dan edukasi terkait pencegahan dan penanganan cedera sprain ankle memiliki dampak yang positif untuk meningkatkan pengetahuan siswa-siswi SMA 11 Samarinda.
Enhancing EFL writing skills for adult Deaf and hard of hearing individuals
Authors: Chomicz Marta
Published: January 2025

The paper examines how Deaf and hard of hearing (D/HH) learners use information technology to develop English as a Foreign Language (EFL) writing skills. Conducted during two EU-funded summer schools, one in Italy and one in Poland, the research explores how internet tools like Google Translate, ChatGPT, and online dictionaries affect writing quality and confidence among 18 adult D/HH participants. The findings indicate that participants perceived these tools as improving vocabulary, grammar, coherence, and writing confidence. Moreover, the study highlights the creative strategies D/HH learners use to overcome linguistic challenges, such as employing simple and direct language, imaginative storytelling, and using visual imagery. Participants demonstrated resourcefulness in conveying complex ideas despite limitations in vocabulary and grammar, even when writing without technology. With the aid of internet tools, these strategies were further enhanced, helping to improve the clarity and structure of their texts. However, the research acknowledges limitations of relying heavily on technology, as it may limit opportunities for independent language growth. The study emphasizes the need for a balanced approach that integrates both technology and traditional methods to foster comprehensive EFL skill development.
Soil porosity as a key factor of soil aggregate stability: insights from restricted grazing
Authors: Yang Yi , Meng Zhongju , Li Haonian , Gao Yue , Li Tianyang , Qin Lei
Published: January 2025

Overgrazing leads to steppe degradation and soil structure deterioration, which is common in desert steppes. Restricted grazing is a sustainable practice, but the mechanisms by which soil structure responds to restricted grazing have received little attention. This study examined the effects of two different grazing management strategies, namely, restricted grazing and free grazing (CK), on soil structure indicators in the desert steppe. The restricted grazing further included grazing exclusion (GE) and seasonal grazing (SG). Additionally, a preliminary exploration was conducted to identify the main factors affecting the soil aggregate stability. Our results demonstrated that GE significantly increased clay (<0.002 mm) and silt (0.002–0.02 mm) in the 0–10 cm and 10–20 cm layers by an average of 71.27% and 70.64%, respectively. Additionally, SG significantly increased clay (<0.002 mm), silt (0.002–0.02 mm), and macroaggregates (>0.25 mm) in the 0–10 cm layer. GE significantly increased soil organic carbon in the 0–10 cm and 10–20 cm layers by 7.02 g/kg and 7.45 g/kg, respectively. In addition, SG had no significant effect on soil organic carbon. The findings obtained from the computations using the boosted regression tree (BRT) demonstrated that, within the study period, soil porosity significantly affects soil aggregate stability compared to other factors. Moreover, it possessed an average explanatory power that surpassed 45%. Overall, the soil structure is better under GE than under SG, and GE is the key to improving the soil structure of desert steppe. The research will contribute to a more profound comprehension of the impact of grazing on soil structure. Therefore, it is recommended that grazing closures be prioritized in desert grasslands to promote coordination between grassland restoration and livestock development.
A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies
Authors: Perillat Lucie , McFadyen Andrew , Furlong Patricia , Anderson James
Published: January 2025

Bespoke therapies represent a promising tool to address a diverse range of genetic and acquired conditions, offering new hope where conventional treatments have fallen short. With the rapid rise of bespoke therapies, profound ethical and regulatory challenges emerge, making it crucial to establish a comprehensive framework that ensures these treatments reach clinical settings and meet patients’ needs as quickly as possible while protecting all parties involved. Although current guidelines are continually evolving to address the range of ethical tensions raised by these therapies, several gaps remain. A significant unresolved question is determining where personalized interventions fall on the research-care continuum and understanding the institutional, regulatory, and ethical implications when custom therapies are classified as research, care, or a mix of both. To address these questions, we introduce a conceptual model alongside practical guidance for the development, administration, and evaluation of individualized therapies, using CRISPR/Cas9-based interventions for Duchenne Muscular Dystrophy as a case study. We argue that the goals of an intervention should be as individualized as the bespoke product itself, tailored to the specifics of each case. Rather than attempting to pinpoint the exact location of an intervention on the continuum, which may be hard to operationalize and have limited utility, our approach focuses on the practical details of how such interventions are administered and the individual component parts of an intervention. It advocates for transparent discussions among all partners to anticipate and adjust various components/parameters along the process of administering individualized interventions. Our paper highlights the most critical of these parameters in (1) the planning and development of individualized therapies in laboratory settings, (2) their regulatory oversight, and (3) evaluation. By discussing these stages and parameters in detail, we aim to provide guidance on how to navigate the ethical complexities inherent to individualized interventions and offer a preliminary framework for balancing the interplay between research objectives and patient care needs. Acknowledging that the scientific rigor and adequacy of any new model must be evaluated, we also identify the types of evidence that are required to validate that our model effectively meets individual and societal needs.
Unraveling nitrogen metabolism, cold and stress adaptation in polar Bosea sp. PAMC26642 through comparative genome analysis
Authors: Khanal Anamika , Han So-Ra , Lee Jun Hyuck , Oh Tae-Jin
Published: January 2025

Nitrogen metabolism, related genes, and other stress-resistance genes are poorly understood in Bosea strain. To date, most of the research work in Bosea strains has been focused on thiosulfate oxidation and arsenic reduction. This work aimed to better understand and identify genomic features that enable thiosulfate-oxidizing lichen-associated Bosea sp. PAMC26642 from the Arctic region of Svalbard, Norway, to withstand harsh environments. Comparative genomic analysis was performed using various bioinformatics tools to compare Bosea sp. PAMC26642 with other strains of the same genus, emphasizing nitrogen metabolism and stress adaptability. During genomic analysis of Bosea sp. PAMC26642, assimilatory nitrogen metabolic pathway and its associated enzymes such as nitrate reductase, NAD(P)H-nitrite reductase, ferredoxin-nitrite reductase, glutamine synthetase, glutamine synthase, and glutamate dehydrogenase were identified. In addition, carbonic anhydrase, cyanate lyase, and nitronate monooxygenase were also identified. Furthermore, the strain demonstrated nitrate reduction at two different temperatures (15°C and 25°C). Enzymes associated with various stress adaptation pathways, including oxidative stress (superoxide dismutase, catalase, and thiol peroxidase), osmotic stress (OmpR), temperature stress (Csp and Hsp), and heavy metal resistance, were also identified. The average Nucleotide Identity (ANI) value is found to be below the threshold of 94-95%, indicating this bacterium might be a potential new species. This study is very helpful in determining the diversity of thiosulfate-oxidizing nitrate-reducing bacteria, as well as their ability to adapt to extreme environments. These bacteria can be used in the future for environmental, biotechnological, and agricultural purposes, particularly in processes involving sulfur and nitrogen transformation.
The association between a body shape index and depressive symptoms: a cross-sectional study using NHANES data (2011–2018)
Authors: Zhang Zheng , Ruan Xiang-Yan , Ma Wei
Published: January 2025

Objective

This study aimed to explore the relationship between A Body Shape Index (ABSI) and depressive symptoms, and to evaluate the moderating effects of sociodemographic, lifestyle, and health factors.

Methods

We analyzed data from 19,659 participants in the 2011–2018 National Health and Nutrition Examination Survey (NHANES). Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). ABSI was calculated from waist circumference, height, and BMI. Multiple linear regression models were employed to investigate the association between ABSI and depressive symptoms, with subgroup analyses to examine potential associations within specific populations.

Results

Higher ABSI was significantly associated with increased depressive symptoms, after adjusting for covariates including age, sex, race, marital status, poverty-income ratio, smoking, alcohol consumption, physical activity, diabetes, and hypertension. Individuals in the highest ABSI quartile (Q4) had significantly more depressive symptoms compared to those in the lowest quartile (Q1) (β = 0.22, 95% CI = 0.02–0.41, p = 0.0323). Subgroup analyses revealed that marital status and hypertension significantly moderated the association between ABSI and depressive symptoms.

Conclusion

This study provides the first comprehensive analysis of the link between ABSI and depressive symptoms, suggesting that higher ABSI is associated with greater depressive symptoms. These findings highlight the potential importance of waist circumference and abdominal fat distribution in assessing depression risk. Future research should explore the causal mechanisms underlying this association and investigate the biological pathways involved, to inform more effective strategies for depression prevention and intervention.
Temporal trends, associated risk factors and longitudinal cardiovascular outcomes of body roundness among middle-aged and older Chinese adults: from the China Health and Retirement Longitudinal Study 2011–2018
Authors: Gan Ying-Yuan , Luo Yun-Dan , Zhai Lu , Huo Rong-Rui , Dai Xia , Liao Qian
Published: January 2025

Background

Obesity is a major global health issue, driving high morbidity and mortality rates. The body roundness index (BRI), which includes waist circumference, offers a more accurate measure of visceral and total body fat. However, despite evidence of BRI's effectiveness in predicting obesity-related diseases, national-level data, especially from non-Western populations like China, remain limited.

Methods

This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), a large, nationally representative cohort of Chinese adults, to examine the temporal trends of BRI, identify associated risk factors, and investigate the longitudinal associations between BRI and cardiovascular disease (CVD) outcomes. BRI was calculated using height and waist circumference measurements. Temporal trends and risk factors were analyzed cross-sectionally, while longitudinal associations were examined using Cox proportional hazards models adjusted for confounders. Mediation analyses were conducted to assess the role of intermediate factors such as hypertension and diabetes in the relationship between BRI and CVD.

Results

A total of 12,902 participants were included for risk factor analysis, 10,525 for longitudinal analysis, and 7,310 for cumulative analysis. BRI continued to rise slowly across survey cycles but was higher in women, older adults, and urban residents. Multivariable analysis identified age, alcohol consumption, elevated blood pressure, and diabetes as positive predictors of BRI, while male sex, rural residence, and smoking were negatively associated. Higher baseline BRI was significantly associated with increased CVD risk (HR: 1.44, 95% CI: 1.22–1.69), stroke (HR: 1.49, 95% CI: 1.12–1.98), and heart disease (HR: 1.47, 95% CI: 1.22–1.77). Cumulative BRI similarly predicted increased risks of CVD, stroke, and heart disease. Mediation analysis showed that hypertension accounted for 20.69% of the association between BRI and CVD risk.

Conclusions

BRI is a robust predictor of CVD risk. Targeting hypertension and other metabolic conditions could mitigate the elevated CVD risk associated with high BRI in Chinese adults. These findings underscore the importance of incorporating BRI into public health strategies to better manage obesity-related health risks in China.
Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials
Authors: Dai Jiaxing , Shui Huili , Wu Yuan , Zhang Huanghui , Li Yuanyin , Zhang Shaowang , Yang Bing , Tang Dongxin
Published: January 2025

Purpose

The Jianpi therapeutic strategy in traditional Chinese medicine aims to enhance the spleen’s digestive function and overall wellness. It has shown promise in improving cancer-related fatigue (CRF). This research systematically evaluates the effectiveness of Jianpi therapy in reducing fatigue in cancer patients through a meta-analytic review.

Methods

An exhaustive search was performed within PubMed, Embase, Web of Science, Cochrane Library, SinoMed, Wanfang Data, China Science and Technology Journal Database, and China National Knowledge Infrastructure (CNKI) for randomized controlled trials concerning the application of Jianpi therapy to address CRF. The search spanned from the commencement of each database’s records to April 1, 2024. The extracted data were subjected to analysis using Stata (Version 15.1), with the selection of either a random-effects or fixed-effects model based on the heterogeneity among studies. Outcome measures were demonstrated with standardized mean differences (SMDs) or mean differences (MDs), and each complemented by a 95% confidence interval (CI). The Cochrane Risk of Bias Assessment Tool 2.0 was utilized to assess the potential biases within the studies.

Results

A comprehensive analysis was performed on 45 eligible studies, all of which were conducted within China and encompassed a total of 3,596 participants. The meta-analysis indicated that Jianpi decoction alone exhibited the most significant improvement in the proportion of CD4 cells (SMD=1.34, 95% CI 0.54 to 2.31, P<0.001) and hemoglobin (MD=7.45, 95% CI 4.18 to 10.72, Z=4.47, P<0.001), while also more significantly reducing Piper Fatigue Scale scores (SMD=-2.05, 95% CI -2.71 to -1.39, P<0.001). The combined therapy, which integrated Jianpi therapy with standard care, demonstrated the greatest advantage in enhancing the proportion of CD3 cells (SMD=1.25, 95% CI 0.46 to 2.04, P<0.001). Furthermore, Jianpi therapy was found to be effective in lowering tumor necrosis factor-alpha levels (MD=-7.79, 95% CI -11.24 to -4.34, P<0.001) and concurrently enhancing interferon-gamma (MD=5.15, 95% CI 3.20 to 7.09, P=0.002), interleukin-2 (MD=8.37, 95% CI 6.14 to 10.59, P<0.001).

Conclusion

Our research indicates that Jianpi therapy effectively alleviates CRF, reduces inflammation, and strengthens immune function. However, further high-quality, multicenter randomized controlled trials are essential to confirm these findings and strengthen the evidence.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024566739.
Development and validation of a questionnaire for table tennis teaching in physical education
Authors: Ortega-Zayas Miguel Ángel , Cardona-Linares Antonio José , Quílez Alberto , García-Giménez Alejandro , Lecina Miguel , Pradas Francisco
Published: January 2025

This study aimed to validate the “Racquet Sports Attitude Scale (RSAS)” questionnaire intended for the educational field. The RSAS is a Spanish instrument developed using the Delphi method and consists of 42 questions divided into five subsections benefits of table tennis (TT), facilitators for the application of TT, barriers to applying tennis table in physical education (PE), difficulties in applying the tennis table as a PE content and positive attitude toward racket sports), designed to evaluate the use and impact of the practice of the racket sports, in particular TT, among PE teachers. The semantic validation process involved a panel of experts (n = 16), followed by an evaluation carried out by a group of teachers from various secondary schools (n = 20). Three studies were conducted, the first of which was descriptive, comparative and correlational, to establish the data’s sociodemographic characteristics. The second was an exploratory factor analysis to confirm the number of dimensions of the questionnaire and its reliability and validity. The last study was a confirmatory factor analysis (to establish the final number of items and their structure. The ordinal alpha values ranged from 0.65 to 0.72, obtaining an average value of 0.70, indicating coherence between the measurement of the items. Chi-square values (X2 = 197.383; p < 0.001; CFI = 0.934; TLI = 0.923 and RMSEA = 0.030), showed that the original 5-factor model and 21 final items prevailed over the one-factor model, obtaining values >0.90. On the other hand, the validation results indicated that the factor structure of the RSAS scale was able to explain 46.72% of the variance (F1 = 13.93%; F2 = 10.97%; F3 = 8.57%; F4 = 6.85%; F5 = 6.38). It can be concluded that the structure of the RSAS is fully confirmed by the statistical analyses derived from the different models of structured equations and confirmatory factor analysis, suggesting that the validated model optimally addresses the data provided and contributes to the validation of the questionnaire under study.
Bringing MDMA-assisted therapy for PTSD to traditional healthcare systems: tending to set and setting
Authors: Perivoliotis Dimitri , Knopp Kayla , Remick Shannon , Kaigle Allie , Stauffer Christopher S. , Khalifian Chandra , Wachsman Tamara R. , Chargin Bettye E. , Bismark Andrew W. , Alam Al , Morland Leslie
Published: January 2025

Although effective evidence-based trauma-focused psychotherapies for posttraumatic stress disorder (PTSD) are available, a significant proportion of patients show a suboptimal response or do not complete them. MDMA-assisted therapy (MDMA-AT) for PTSD is a promising intervention currently being evaluated in numerous studies worldwide, including investigation for potential Food and Drug Administration (FDA) approval in the United States. The concepts of set and setting are foundational in psychedelic therapy and refer to the mindset a person brings to therapy and the environment in which it takes place, respectively. Both are believed to play a critical role in the individual’s experience and efficacy of MDMA-AT. In this article, we describe the importance of set and setting in MDMA-AT for PTSD and outline the advantages and challenges of implementing this novel intervention in large healthcare settings such as the Veterans Health Administration (VHA). Mostly derived from our experience conducting clinical trials of MDMA-AT for PTSD in VHA, we present specific and practical suggestions for optimizing set and setting from both the participant’s and clinician’s perspective in a manner that both leverages the opportunities of such settings and adapts to their challenges. These recommendations are intended to inform future MDMA-AT for PTSD research and, potentially, eventual clinical implementation efforts in traditional healthcare systems.
Evaluation of PID-Based Algorithms for UGVs
Authors: Gameiro Tiago , Pereira Tiago , Moghadaspoura Hamid , Di Giorgio Francesco , Viegas Carlos , Ferreira Nuno , Ferreira João , Soares Salviano , Valente António
Published: January 2025

The autonomous navigation of unmanned ground vehicles (UGVs) in unstructured environments, such as agricultural or forestry settings, has been the subject of extensive research by various investigators. The navigation capability of a UGV in unstructured environments requires considering numerous factors, including the quality of data reception that allows reliable interpretation of what the UGV perceives in a given environment, as well as the use these data to control the UGV’s navigation. This article aims to study different PID control algorithms to enable autonomous navigation on a robotic platform. The robotic platform consists of a forestry tractor, used for forest cleaning tasks, which was converted into a UGV through the integration of sensors. Using sensor data, the UGV’s position and orientation are obtained and utilized for navigation by inputting these data into a PID control algorithm. The correct choice of PID control algorithm involved the study, analysis, and implementation of different controllers, leading to the conclusion that the Vector Field control algorithm demonstrated better performance compared to the others studied and implemented in this paper.
Study on A-Star Algorithm-Based 3D Path Optimization Method Considering Density of Obstacles
Authors: Yoo Yong-Deok , Moon Jung-Ho
Published: January 2025

Collision avoidance and path planning are essential for ensuring safe and efficient UAV operations, particularly in applications like drone delivery and Advanced Air Mobility (AAM). This study introduces an improved algorithm for three-dimensional path planning in obstacle-rich environments, such as urban and industrial areas. The proposed approach integrates the A* search algorithm with a customized heuristic function which incorporates local obstacle density. This modification not only guides the search towards more efficient paths but also minimizes altitude variations and steers the UAV away from high-density obstacle regions. To achieve this, the A* algorithm was adapted to output obstacle density information at each path node, enabling a subsequent refinement process. The path refinement applies a truncation algorithm that considers both path angles and obstacle density, and the refined waypoints serve as control points for Non-Uniform Rational B-Splines (NURBS) interpolation. This process ensures smooth and dynamically feasible trajectories. Numerical simulations were performed using a quadrotor model with integrated PID controllers in environments with varying obstacle densities. The results demonstrate the algorithm’s ability to effectively balance path efficiency and feasibility. Compared to traditional methods, the proposed approach exhibits superior performance in high-obstacle-density environments, validating its effectiveness and practical applicability.
Integrated Model to Reduce the Maneuver Time of the Harvester and Infield Wagon in Sugarcane Harvest
Authors: Corrêa Lígia Negri , dos Santos Adão Felipe , Furlani Carlos Eduardo Angeli , Rolim Glauco de Souza , Vieira Igor Cristian de Oliveira , dos Santos Silva Breno , Siansi Frederico Luiz , da Silva Rouverson Pereira
Published: January 2025

This study aims to enhance the efficiency of mechanized sugarcane (Saccharum spp.) harvesting by optimizing the maneuvers of the auxiliary vehicle (infield wagon) operating in tandem with the harvester. The optimization focuses on increasing productivity and reducing soil compaction in high-traffic maneuver areas. A comprehensive three-year experimental study was conducted in agricultural fields at a Brazilian mill, where extensive field data and economic parameters were collected to simulate and compare maneuvering techniques on both flat and sloped terrain. To evaluate the synchronization between the harvester and the infield wagon under non-optimized scenarios, a Maneuver Simultaneity Index (MSI) was developed. The results demonstrated that the optimized “P-optimized” technique, which utilizes dedicated maneuvering spaces, significantly increased economic returns per hour worked by reducing maneuver times across various terrain types. Additionally, fuel consumption decreased with the adoption of the optimized maneuver pattern, leading to lower operational costs and reduced environmental impact. These findings highlight the economic and operational feasibility of optimizing maneuver patterns, particularly in flat areas, and provide a sustainable framework adaptable for improving efficiency and productivity in diverse mechanized agricultural operations.
Treatment of Ferruginous Water in the Performance of Drip Irrigation Systems
Authors: Cordeiro Elio de Almeida , Mantovani Everardo Chartuni , Vieira Gustavo Haddad Souza , Silva José Geraldo Ferreira da , Haddade Ismail Ramalho , Lo Monaco Paola Alfonsa Vieira
Published: January 2025

One of the most important advantages of drip irrigation is the possibility of achieving a high uniformity of water distribution. However, this uniformity can be reduced when using water with high iron content, which can cause drippers to clog. This study aimed to verify the efficiency of the chlorination, aeration, decantation and filtration processes carried out to remove the iron from irrigation water and to investigate the effect of iron on water distribution uniformity. Four similar irrigation systems with five models of drippers were installed. The results showed that (i) there was a significant difference in the drippers’ behavior in relation to susceptibility to clogging when using water with a high iron content; (ii) the use of disk filters alone was not able to promote significant reductions in the iron quantity as a way to prevent the clogging of drippers; and (iii) the use of aerators followed by sedimentation tanks made it possible to achieve a considerable improvement in the water application uniformity for drippers that were more sensitive to clogging caused by the use of water with high iron content.
Blood-Based Whole-Genome Methylation Analysis of Yili Horses Pre- and Post-Racing
Authors: Wang Jianwen , Ren Wanlu , Li Zexu , Ma Shikun , Li Luling , Wang Ran , Zeng Yaqi , Meng Jun , Yao Xinkui
Published: January 2025

This study aims to analyze the whole-genome DNA methylation differences in Yili horses before and after racing, with the goal of identifying differentially methylated genes associated with racing performance and exploring the epigenetic mechanisms underlying exercise in horses. Blood samples were collected from the jugular veins of the top 3 Yili horses in a 5000 m race, which included 25 competitors, both prior to and within 5 min after the race. Genomic DNA was extracted, followed by sequencing using Whole-Genome Bisulfite Sequencing (WGBS) to assess DNA methylation levels, differentially methylated regions (DMRs), and differentially methylated genes (DMGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on the identified DMGs to select candidate genes potentially associated with equine exercise. A total of 18,374 differentially methylated CG regions, 254 differentially methylated CHG regions, and 584 differentially methylated CHH regions were identified. A total of 4293 DMGs were anchored in gene bodies and 2187 DMGs in promoter regions. Functional analysis revealed that these DMGs were mainly enriched in terms related to binding and kinase activity, as well as pathways such as PI3K-Akt signaling and Kaposi sarcoma-associated herpesvirus infection. Further analysis indicated that genes such as IFNAR2, FGF4, and DGKH could be potential candidate genes associated with equine athletic performance. The findings of this study contribute to understanding the epigenetic regulatory mechanisms of equine athletic performance, providing a reference for further in-depth research on horse racing.
Characterization of TCRβ and IGH Repertoires in the Spleen of Two Chicken Lines with Differential ALV-J Susceptibility Under Normal and Infection Conditions
Authors: Wang Meihuizi , Zhang Qihong , Ju Rongyang , Xia Junliang , Xu Chengxun , Chen Weiding , Zhang Xiquan
Published: January 2025

This study investigates the immunological factors underlying the differential susceptibility of two chicken strains, E- and M-lines, to avian leukosis virus subgroup J (ALV-J). During the eradication of avian leukosis at a chicken breeder farm in Guangdong, we observed strain-specific differences in susceptibility to ALV-J. Moreover, E-line chickens exhibited a slower antibody response to ALV-J compared to M-line chickens. As the T cell receptor (TCR) and B cell receptor (BCR) are critical for antigen recognition, their activation triggers specific immune responses, including antibody production. Using high-throughput sequencing, we characterized the T cell receptor beta (TCRβ) and immunoglobulin heavy chain (IGH) repertoires in spleen tissues from both chicken strains. The M-line demonstrated higher clonal diversity in both TCRβ and IGH repertoires under normal conditions compared to the E-line, suggesting a broader baseline antigen recognition capacity. Following ALV-J infection, the TCRβ repertoire diversity remained unchanged, while the IGH repertoire displayed distinct clonal expansion patterns and complementarity-determining region 3 (CDR3) length distributions between the two lines, potentially affecting their ability to recognize ALV-J antigens. Our study provides the first comprehensive comparison of TCRβ and IGH repertoire dynamics in chickens with different ALV-J susceptibilities, offering new insights into the molecular and immunological mechanisms underlying resistance to ALV-J.
Long-Interval Prostaglandin F2α Combined with GnRH Improves the Estrus Synchronization and Reproductive Performance of Sheep During the Breeding Season
Authors: Duan Zengyi , Liu Menghao , Li Junjin , Hou Jian
Published: January 2025

To improve the efficiency of prostaglandin F2α (PG)-based estrus synchronization in sheep, this study assessed the effect of the gonadotropin-releasing hormone (GnRH) included in the long-interval PG treatment regimen for sheep estrus synchronization during the breeding season. In experiment 1, 30 multiparous Mongolian sheep (3–4.5 years old) were randomly divided into three groups. In the progesterone (P4)–equine chorionic gonadotropin (eCG) group (P4-eCG, n = 10), the ewes were synchronized with intravaginal P4 sponges for 14 days, and received an injection of 330 IU of eCG at sponge withdrawal. In the PG group (n = 10), the ewes received two doses of 0.1 mg PG with a 14 day interval. In the PG-GnRH-PG group (n = 10), the ewes were synchronized by two doses of 0.1 mg PG with a 14 day interval like that in the PG group, but received 50 μg of GnRH 7 days after the first injection of PG. It was found that, at the end of treatment, the number of corpus luteum on the ovaries and the concentration of the serum P4 in the PG-GnRH-PG group were significantly higher than that of the PG and P4-eCG groups. In experiment 2, 59 multiparous Mongolian sheep (3–4.5 years old) were assigned to three groups, like in experiment 1 (n = 20, 20 and 19 for the P4-eCG, PG and PG-GnRH-PG groups, respectively). The estrus of ewes in the PG-GnRH-PG group was more synchronous compared to the PG group. After insemination of the estrus ewes, the pregnancy rate was numerically but not significantly higher in the PG-GnRH-PG group than that in the P4-eCG and the PG groups. In a field test, 285 multiparous Hu sheep (3–4.5 years old) were randomly assigned to a P4-eCG group (n = 142) and PG-GnRH-PG group (n = 143). Timed artificial insemination showed no significant differences in the rates of pregnancy and lambing between the PG-GnRH-PG and P4-eCG groups. We conclude that the addition of GnRH in the long-interval PG protocol may improve the efficiency of PG-based estrus synchronization, and would represent a potential alternative to the conventional P4-eCG based protocol during the breeding season in sheep.
Factors Associated with Compassion Fatigue in Assistance Animal Trainers in Australia—A Qualitative Investigation
Authors: Verrall James , Rohlf Vanessa , Howell Tiffani J.
Published: January 2025

Assistance animal (AA) trainers could develop compassion satisfaction (CS) but also compassion fatigue (CF), due to potential exposure to suffering through working with people with disabilities. The negative outcomes associated with CF could result in fewer trainers and longer wait times for people in need. Using the Job Demands–Resources Model (JD-R), this study aimed to qualitatively identify the demands and resources of AA trainers and explore signs of CF and CS. Six trainers participated in semi-structured interviews, and five themes were identified. The Demands theme represented challenges trainers experienced, such as concerns about animal welfare and client wellbeing. The Resources theme represented personal characteristics and job aspects that assisted the trainers, like resilience and formal support from the employer. Negative Impacts included signs of CF and represented how participants were negatively affected by their job. Similarly, Positive Impacts included signs of CS and represented how participants were positively affected. Misguided Trainer Expectations represented the expectations trainers had starting the job compared to the reality of the role. The discovery of CF signs provides evidence of a previously unidentified psychosocial hazard for trainers. These findings should be used by training organizations to better support trainers.
Genome Wide Identification of Structure Variations in Five Italian Turkey Populations
Authors: Saleh Medhat S. , Landi Vincenzo , Derks Martijn F. L. , Centoducati Gerardo , Groenen Martien A. M. , De Palo Pasquale , Ciani Elena , Pugliese Nicola , Circella Elena , Camarda Antonio
Published: January 2025

Structural variants (SVs) are one of the main sources of genetic variants and have a significant impact on phenotype evolution, disease susceptibility, and environmental adaptations. We used 73 whole genome sequencing (12x) to apply a mapping approach to identify SVs in five turkey populations. A notable degree of genetic isolation was observed between the Basilicata and Apulian populations, as indicated by principal component analysis and admixture results. A total of 11,733 SVs were detected, including 6712 deletions, 2671 duplications, 1430 inversions, and 920 translocations. The Variant Effect Predictor (VEP) analysis predicted various consequences of filtered SVs as follows: intron variants (35.8%), intergenic variants (9.6%), coding sequence variants (8.3%), downstream gene variants (7.5%), and transcript ablations (7.3%). Our functional annotation of genes overlapping with SVs was mainly enriched in recognized pathways governing positive regulation of nucleoplasm, protein binding, mitochondrion, negative regulation of cell population proliferation, identical protein binding, and calcium signaling. We produced a comprehensive SV catalog utilizing unique whole-genome turkey data. This SV catalog not only increases our understanding of genetic diversity in turkeys but also enhances our knowledge of the role of SVs in their phenotypic traits.
Recognition of Foal Nursing Behavior Based on an Improved RT-DETR Model
Authors: Liu Yanhong , Zhou Fang , Zheng Wenxin , Bai Tao , Chen Xinwen , Guo Leifeng
Published: January 2025

Foal nursing behavior is a crucial indicator of healthy growth. The mare being in a standing posture and the foal being in a suckling posture are important markers for foal suckling behavior. To enable the recognition of a mare’s standing posture and its foal’s suckling posture in stalls, this paper proposes an RT-DETR-Foalnursing model based on RT-DETR. The model employs SACGNet as the backbone to enhance the efficiency of image feature extraction. Furthermore, by incorporating a multiscale multihead attention module and a channel attention module into the Adaptive Instance Feature Integration (AIFI), the model strengthens feature utilization and integration capabilities, thereby improving recognition accuracy. Experimental results demonstrate that the improved RT-DETR achieves a best mAP@50 of 98.5%, increasing by 1.8% compared to the RT-DETR. Additionally, this study achieves real-time statistical analysis of the duration of the foal in the suckling posture, which is one of the important indicators for determining whether the foal is suckling. This has significant implications for the healthy growth of foals.
Adherence to Perioperative Antimicrobial Prophylaxis in Children in the Settings of Neurosurgery, Otorhinolaryngology, and Orthopedics
Authors: Dimopoulou Dimitra , Tsakali Athina , Berikopoulou Maria M. , Dimopoulou Anastasia , Kamposou Vasiliki , Panagopoulos Dimitrios , Papadakis Christos-Sotiris , Tokis Vasileios , Pouli Konstantina , Bozonelos Georgios , Anastasopoulos John , Antonis Konstantinos , Papapetropoulos Nektarios , Michos Athanasios
Published: January 2025

Introduction: Data about compliance with perioperative antimicrobial prophylaxis (PAP) guidelines in the pediatric population are limited. This study aims to evaluate PAP adherence in pediatric surgical subspecialty departments. Methods: A prospective cohort study was conducted from September 2023 to October 2024 at “Aghia Sophia” Children’s Hospital, Athens, Greece. Children <16 years old undergoing surgical procedures in the neurosurgery (NS), orthopedics (OP), and otolaryngology (ORL) departments were included. Data on demographics, surgical characteristics, and PAP practices (timing, agent, duration, and redosing) were collected and compliance with the international guidelines was evaluated. Results: A total of 301 children were included, with a median age (IQR) of 7 (8) years. PAP was received by 249/301 (82.7%) children (100% in the OP and NS, and 48% in the ORL). However, indications for PAP had 50.8% of children: 102/103 (99%) in the NS, 47/98 (47.9%) in the OP, and 4/48 (8.3%) in the ORL. Most children received broad-spectrum or combination of antimicrobials and/or antibiotics for longer duration. Appropriate PAP according to the guidelines was administered in 0% children in NS, 2% in OP, and 2.1% in ORL. Multivariable analysis in the ORL regarding the use of PAP revealed that shorter procedures (≤60 min; OR: 22.9, p = 0.003) and clean wounds (OR: 33.4, p < 0.001) were significantly associated with not using PAP. Conclusions: This study highlights gaps in the PAP guideline adherence in pediatric surgical departments, and the need for educational interventions to improve compliance and reduce antimicrobial use. Based on these findings, we plan to implement an educational intervention in order to optimize PAP practices in the pediatric population.