bluuebunny/crossref_metadata_2025 huggingface dataset:
Facial erythema in patients with atopic dermatitis treated with Dupilumab – a descriptive study of morphology and Aetiology
Authors: Ahn J. , Lee D.H. , Na C.H. , Shim D.H. , Choi Y.S. , Jung H.J. , Simpson E.L.
Published: June 2022

Background

The development of dermatitis on face and neck, which was not described in phase 3 clinical trials, has been reported in the literature in patients treated with dupilumab. Little is known regarding the causes or defining features of the facial dermatitis.

Objectives

We conducted surveys of consecutive patients with AD on dupilumab to describe its clinical features, morphology and aetiology.

Methods

A multi‐centre prospective cohort study was conducted from 1 January 2020, to 31 December 31 2020. A total of 162 patients under dupilumab treatment were asked to complete a questionnaire and patients were evaluated by dermatologists.

Results

Of all 162 patients, 137 (84.6%) patients reported pre‐existing facial dermatitis prior to dupilumab therapy. One hundred and twenty‐one (88.3%) patients with pre‐existing facial dermatitis reported improvement of their facial dermatitis with dupilumab therapy, nine (6.6%) patients reported no change after the treatment and seven (4.3%) patients of them got worse after the treatment (exacerbation group). Of 25 patients who reported no pre‐existing active facial dermatitis, six (24%) patients reported new‐onset facial erythema after the starting dupilumab therapy (new‐onset group). A large proportion of the patients in both the exacerbation (86%) and new‐onset groups (67%) had a history of facial TCS use. Both groups showed similar clinical manifestations and distribution with few differences.

Conclusions

The vast majority of patients treated with dupilumab in academic institutions from Korea and the United States experienced improvement in their facial dermatitis with dupilumab therapy. A small proportion of patients had new onset and exacerbation. Although the mechanisms of this adverse event remain unclear, steroid withdrawal should be considered as a diagnosis of the erythema in some patients.
Secukinumab demonstrated sustained retention, effectiveness and safety in a real‐world setting in patients with moderate‐to‐severe plaque psoriasis: long‐term results from an interim analysis of the SERENA study
Authors: Augustin M. , Sator P.G. , von Kiedrowski R. , Conrad C. , Rigopoulos D. , Romanelli M. , Ghislain P.‐D. , Torres T. , Ioannides D. , Aassi M. , Schulz B. , Jagiello P. ,   SERENA study group
Published: June 2022

Background

Randomized controlled trials of secukinumab have shown sustained efficacy and a favourable safety profile in multiple manifestations of psoriatic disease.

Objectives

To assess the long‐term, real‐world retention, effectiveness and safety of secukinumab in routine clinical practice for the treatment of moderate‐to‐severe plaque‐type psoriasis (PsO).

Methods

SERENA (CAIN457A3403) is a large, ongoing, longitudinal, observational study conducted at 438 sites and 19 countries for an expected duration of up to 5 years in adult patients with moderate‐to‐severe PsO, psoriatic arthritis and ankylosing spondylitis. Patients received ≥16 weeks of secukinumab treatment before enrolment. This interim analysis presents data from PsO patients, who were enrolled in the study between October‐2016 and October‐2018 and were observed for ≥2 years.

Results

In total, 1756 patients (67.3% male) with a mean age of 48.4 years and body mass index of 28.8 kg/m2 were included in the analysis. The secukinumab treatment retention rates after 1, 2 and 3 years in the study were 88.0%, 76.4% and 60.5%, respectively. Of the 648 patients who discontinued the study, the most common reasons included lack of efficacy (42.6%), adverse event (17.4%), physician decision (12.2%) and subject decision (11.6%). Mean ± SD absolute PASI was 21.0 ± 13.0 at the start of treatment (n = 1,564). At baseline, the mean ± SD PASI score reduced to 2.6 ± 4.8 and remained low at Year 1 (2.3 ± 4.3), Year 2 (1.9 ± 3.6) and Year 3 (1.9 ± 3.5). The safety profile of secukinumab during the SERENA study was consistent with its known safety profile, with no new safety signals reported. Particularly, low rates of inflammatory bowel disease (0.3%; Incidence Rate [IR]:0.15), candida infections (3.1%; IR:1.43) and MACE (0.9%; IR:0.37) were observed.

Conclusions

Secukinumab showed high treatment persistence, sustained effectiveness and a favourable safety profile up to 3 years of follow‐up in the real‐world population of PsO patients observed in SERENA.
Tilapia Lake Virus (TiLV) from Vietnam is genetically distantly related to TiLV strains from other countries
Authors: Tran Triet Hanh , Nguyen Vy Thuy Hoang , Bui Hieu Chi Nguyen , Tran Yen Binh Thi , Tran Huong Thanh Thi , Le Thao Thu Thi , Vu Huong Thanh Thi , Ngo Thao Phuong Huynh
Published: June 2022

Tilapia Lake Virus (TiLV) is reported as a threat to tilapia aquaculture in 16 countries on four continents with outbreaks causing up to 90% mortality. This research is one of the first studies on TiLVs from Vietnam. We propagated successfully one TiLV isolate HB196‐VN‐2020 from a diseased tilapia sample using an E‐11 cell line and evaluated its virulence in two different weights of red hybrid tilapia and three serial 10‐fold diluted viral titers. Smaller fish (4.5 ± 1.98 g) were proved to be more susceptible to TiLV infection at the viral titre of 9.1 × 105 TCID50 fish−1 than larger fish (20.8 ± 7.5 g) with the mortalities of 92.5% and 12.5%, respectively. Reassortant detection analysis revealed seven potential reassortment events among 23 TiLV genomes, indicating the mixed infection of multiple TiLV isolates at the farms and the fish movement among different regions. Seven maximum likelihood phylogenetic trees based on the individual segments or the concatenated coding regions of some segments showed the genetically distant relationship of the Southern Vietnamese isolate RIA2‐VN‐2019 with the 21 reference isolates, and suggest the different origins of two Vietnamese TiLV isolates (RIA2‐VN‐2019 and HB196‐VN‐2020). However, additional sequences from various sampling locations and times are required to better understand the impacts of genetic diversity and reassortments on the evolution, migration and natural selection of TiLVs in Vietnam and other countries.
Bored of the rings: Methodological and analytic approaches to operationalizing Bronfenbrenner's PPCT model in research practice
Authors: Navarro Jessica L. , Stephens Christina , Rodrigues Blenda C. , Walker Indya A. , Cook Olivia , O'Toole Leah , Hayes Noírín , Tudge Jonathan R. H.
Published: June 2022

Bronfenbrenner's ecological (and later bioecological) theory has been a mainstay in the theoretical wheelhouse of developmental and family sciences since its inception in the 1970s. However, few studies accurately operationalize Bronfenbrenner's process‐person‐context‐time (PPCT) research model. The aim of this paper is to provide a practical guide to the design, implementation, and analysis of PPCT research studies. Using recent qualitative and quantitative publications from developmental and family science journals, we illustrate how his theory can be operationalized simply and effectively in 21st‐century research. The eight studies, three qualitative and five quantitative, feature participants from Chile, China, South Africa, Turkey, and the United States.
Temporomandibular disorders, bite force and osseous changes of the temporomandibular joints in patients with hypermobile Ehlers‐Danlos syndrome compared to a healthy control group
Authors: Bech Karen , Fogh Frederikke Maria , Lauridsen Eva Fejerskov , Sonnesen Liselotte
Published: June 2022

Background

Ehlers‐Danlos syndrome (EDS) is a hereditary disorder that affects the connective tissue and collagen structures in the body characterised by joint hypermobility, skin hyperextensibility and tissue fragility.

Objective

The aim was to investigate temporomandibular disorders (TMD), bite force, teeth in occlusal contact and osseous changes of the temporomandibular joints (TMJs) in 26 patients with hypermobile EDS (hEDS), differentiated by a genetic test, compared to 39 healthy controls.

Methods

Clinical examination according to Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), radiological examinations of the TMJs by cone‐beam‐computed tomographic (CBCT) scans, registration of bite force and teeth in occlusal contact was performed. Statistical analyses included Fisher's Exact Test, multiple logistic and linear regression models adjusted for age, gender and Body Mass Index (BMI).

Results

Single symptoms and signs of TMD occurred significantly more often in hEDS (p = .002;p = .001;p = .003;p = <.0001;p = .012) and maximum mouth opening was significantly smaller in hEDS compared to controls (p = <.0001). The DC/TMD diagnosis myalgia, myofascial pain with referral, arthralgia, headache attributed to TMD, disc displacement disorders and degenerative joint disease occurred significantly more often in hEDS compared to controls (p = .000;p = .008;p = .003;p = .000;p = <.0001;p = .010, respectively). No significant differences were found in bite force and in teeth in occlusal contact between the groups (p > .05). On CBCT of the TMJs, subcortical sclerosis occurred significantly more often in hEDS compared to controls (p = .005).

Conclusion

Symptoms and signs of TMD and osseous changes of the TMJs occurred significantly more often in hEDS. Bite force and teeth in occlusal contact were comparable to controls.
High‐Definition Transcranial Direct Current Stimulation Over the Left Frontopolar Cortex Promotes Analogical Reasoning
Authors: Lundie Michael , Dasara Harshith , Beeghly Christopher , Kazmi Ali , Krawczyk Daniel
Published: June 2022

The objective of this study was to measure the contribution of the left frontopolar cortex (FPC) to analogical reasoning. Our measure of analogical reasoning derives from performance on the radiation problem, a creative problem‐solving task first used in Gestalt psychology (Duncker, 1945). Success on this task is as low as 10 % without the presentation of explicit cues that guide inference toward the solution (Gick & Holyoak, 1980). We assessed whether high‐definition transcranial direct current stimulation of the left FPC would promote the analogical transfer of the radiation problem. We found that anodal stimulation primed analogical transfer and led to improved task performance compared to the cathode and sham control groups. Results from this study offer evidence favoring the hypothesis that stimulating the left FPC facilitates analogical problem‐solving.
Oral carcinoma cuniculatum, the great mimicker: Report of a challenging case and literature review
Authors: Vieira Gustavo de Souza , Câmara Priscilla Rodrigues , Rozza‐de‐Menezes Rafaela Elvira , Dias Eliane Pedra , Cunha Karin Soares
Published: June 2022

Oral carcinoma cuniculatum (OCC) is a rare and locally invasive well‐differentiated variant of squamous cell carcinoma. To date, 74 cases affecting the oral cavity were reported in English‐language literature. We report a case of maxillary OCC in a 71‐year‐old woman and review the demographic, etiological, clinicopathological, therapeutic and prognostic features of the OCC cases published in the English literature. From the 75 cases evaluated, there was no predilection for sex, and the highest incidence was between the seventh and tenth decades of life. Use of alcohol (17.3%), tobacco (29.3%), both (6.7%), and betel chewing (5.3%) were related in some cases. The clinical presentation was variable, and the gingiva and mandibular alveolar ridge were the most affected sites (50.7%). Inconclusive result or misdiagnosis in the initial histopathological examination was reported in more than 40% of cases, which required deeper or more representative biopsies for the definitive diagnosis. Radical surgery was the treatment of choice for 88.0% of cases. Overall, 10.7% of cases had cervical lymph node metastasis and 17.3% had recurrence after initial treatment, with only one death (1.3% of the cases). In conclusion, the wide variety of clinical presentations, lack of cytological atypia in most cases and need for deep incisional biopsies make the diagnosis of OCC challenging. Radical surgery is the main therapeutic modality and local recurrence after initial treatment occurs in less than 20% of cases. Although locally aggressive, regional and distant metastases are rare and the prognosis is good.
Antimicrobial susceptibility and production of virulence factors by bacteria recovered from bitches with pyometra
Authors: Rocha Marcos F. G. , Paiva Débora D. Q. , Amando Bruno R. , Melgarejo Carliane M. A. , Freitas Alyne S. , Gomes Francisco I. F. , Ocadaque Crister J. , Costa Cecília L. , Guedes Glaucia M. M. , Lima‐Neto Reginaldo G. , Cordeiro Rossana A. , Sidrim José J. C. , Castelo‐Branco Débora S. C. M.
Published: June 2022

Pyometra is one of the most common diseases in adult female dogs, characterized by a suppurative bacterial infection of the uterus with accumulation of inflammatory exudate and a variety of local and systemic clinical manifestations. This study aimed to identify the bacteria within the uterine content and vaginal canal of bitches with pyometra and evaluate their antimicrobial susceptibility and production of virulence factors. Uterine and vaginal content were collected with sterile swabs from 30 bitches diagnosed with pyometra. Bacteria were identified and assessed for their antimicrobial susceptibility and production of virulence factors, including biofilms, siderophores, proteases and hemolysins, both in planktonic and biofilm forms. A total of 82 bacterial isolates (35 uterus, 47 vagina), belonging to 21 species, were identified, with Escherichia coli as the most prevalent species (32/82, 39%). As for susceptibility, 39/79 (49.4%) isolates were resistant to one or more drugs, with resistance proportion among Gram‐positive bacteria (87.5%) higher (p < .05) than that observed for Gram‐negative bacteria (32.7%). Four coagulase‐negative Staphylococcus species were resistant to methicillin. Regarding virulence, the isolates had low production of biofilms, siderophores, proteases and hemolysins, suggesting that the occurrence of pyometra might be more associated with host‐related factors than bacterial virulence.
The durability of governance reform: A two‐wave audit of notice and comment policymaking in China
Authors: Balla Steven J. , Xie Zhoudan
Published: June 2022

The notice and comment process, in which government organizations make public draft laws and regulations and solicit feedback on these proposals, is a prominent governance reform in contemporary China. This article examines the durability of notice and comment policymaking by conducting a pair of audits of the practices of dozens of central government ministries and provincial governments. There are a number of reasons to expect that it is difficult to sustain governance reforms in China. Nevertheless, the audits—which the authors carried out in 2014 and 2021—demonstrate that, subject to a number of constraints, notice and comment policymaking was routinely implemented by government organizations throughout the period under analysis. Although the notice and comment process is a durable governance reform, additional research is needed before it can be concluded that the procedure brings more than a veneer of transparency to Chinese policymaking.
Multilevel Network Item Response Modelling for Discovering Differences between Innovation and Regular School Systems in Korea
Authors: Jin Ick Hoon , Jeon Minjeong , Schweinberger Michael , Yun Jonghyun , Lin Lizhen
Published: June 2022

The innovation school system in South Korea has been developed in response to the traditional high-pressure school system in South Korea, with a view to cultivate a bottom-up and student-centred educational culture. Despite its ambitious goals, questions have been raised about the success of the innovation school system. Leveraging data from the Gyeonggi Education Panel Study along with advances in the statistical analysis of network data and educational data, we compare the two school systems in more depth. We find that some schools are indeed different from others, and those differences are not detected by conventional multilevel models. Having said that, we do not find much evidence that the innovation school system differs from the regular school system in terms of self-reported mental well-being, although we do detect differences among some schools that appear to be unrelated to the school system.
Identification and characterization of the novel HLA‐B*49:78 allele by next‐generation sequencing
Authors: Niño Ramírez Jairo Eduardo , Balas Antonio , Balanzategui Ana , Terradillos Pilar , Tejeda Velarde Amalia
Published: June 2022

The novel HLA class I allele, HLA‐B*49:78, was detected in a Spanish Caucasian individual.
Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)
Authors: Freitas Ines , Taeymans Olivier , Knott Tim , Civello Alexander , Wegg Michaela , Gomez Alberto , Oliver James Andrew Clive
Published: June 2022

Purpose

In humans, idiopathic orbital inflammation (IOI) is a diagnosis attributed to benign, inflammatory orbital conditions without identifiable local or systemic cause. We describe the clinical signs, imaging and histopathological findings, management and outcome of four dogs diagnosed with IOI.

Methods

Multicentric retrospective study.

Results

A total of four dogs (five orbits) of three different breeds (three cases were English Springer Spaniels [ESS] or ESS‐cross) and ages ranging from 3 to 12 years were included. Initial presenting signs were unilateral and included exophthalmos, enophthalmos, globe deviation, thickening and protrusion of the third eyelid and conjunctival hyperemia. Computed tomography and magnetic resonance imaging identified heterogeneous space‐occupying, contrast‐enhancing orbital lesions in all cases. Sparing of the retrobulbar space was detected in four of five orbits. Histopathology revealed mixed inflammatory infiltrates of lymphocytes, plasma cells, and histiocytes. Immunohistochemistry was performed in two cases highlighting the presence of histiocytes and lymphocytes, predominantly T cells. Resolution of clinical signs was achieved in two cases managed with oral immunosuppressant medication (corticosteroids alone or combined with cyclosporine or azathioprine), one went into spontaneous remission, one resolved with topical corticosteroids, and one underwent exenteration. Recurrence occurred in two cases within 15 months of initial diagnosis and required further immunosuppressant medication. One case developed signs in the contralateral orbit within 8 months of presentation.

Conclusions

IOI is an uncommon condition in dogs. Its diagnosis relies on the combination of advanced imaging and histology. As in humans, it appears that spontaneous remission and recurrence may occur requiring long‐term immunosuppressant medication.
Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs
Authors: Zhang Jiayu , Xu Yanan , Zhang Yingzi , Bossila Elhusseny A. , Shi Mingpu , Zhao Yong
Published: June 2022

The shortage of allogeneic donor organs leaves its supply far short of clinical need. There are great expectations on xenotransplantation, especially with pigs’ organs. With the genetic modification of donor pigs, the rejection and cross‐species transmission issues have now been widely addressed. However, research on the compatibility of genes between humans and pigs was limited. We performed a systematic screening analysis of predicted incompatible genes between humans and pigs, judged by low protein sequence similarities or different predicted protein domain compositions. By combining with gene set enrichment analysis, we screened out several key genes of hematopoiesis and the immune system with possible incompatibilities, which might be important for establishing chimera and xenotransplantation between humans and pigs. There were seven chemokine genes, including CCL1, CCL5, CCL24, CCL25, CCL28, CXCL12, and CXCL16, that exhibited limited similarity between humans and pigs (similarity < 0.8). Among hematopoiesis process‐related genes, 15 genes of adhesion molecules, Notch ligands, and cytokine receptors exhibited differences between humans and pigs. In complement and coagulation cascades, 19 genes showed low similarity and 77 genes had different domain compositions between humans and pigs. Our study provides a good reference for further genetic modification of pigs, which might be beneficial for xenotransplantation.
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation
Authors: Rodger Daniel , Hurst Daniel J.
Published: June 2022

Mathieu Jaboulay (1860‐1913) was a professor of clinical surgery in Lyon, France who is best known for his development of vascular anastomosis and for conducting the first reported renal xenotransplantation experiments on humans, using pig and goat kidneys to treat end‐stage renal failure in 1906. His insights and pioneering techniques contributed significantly to allotransplantation and contemporary attempts at xenotransplantation. He is also credited with inventing several surgical instruments and novel surgical techniques that continue to influence vascular, general, and urological surgery to this day. However, this article will focus specifically on his notable contributions to xenotransplantation research and surgery.
Viscoelastic Influence on the Board Level Assessment of Wafer Level Packages Under Drop Impact and Under Thermal Cycling
Authors: Misrak Abel , Bhandari Rabin , Agonafer Dereje
Published: June 2022

Structural components such as printed circuit boards (PCBs) are critical in the thermomechanical reliability assessment of electronic packages. Previous studies have shown that geometric parameters such as thickness and mechanical properties like elastic modulus of PCBs have a direct influence on the reliability of electronic packages. Elastic material properties of PCBs are commonly characterized using equipment such as tensile testers and used in computational studies. However, in certain applications viscoelastic material properties are important. Viscoelastic influence on materials is evident when one exceeds the glass transition temperature of materials. Operating conditions or manufacturing conditions such as lamination and soldering may expose components to temperatures that exceed the glass transition temperatures. Knowing the viscoelastic behavior of the different components of electronic packages is important in order to perform accurate reliability assessment and design components such as PCBs that will remain dimensionally stable after the manufacturing process. Previous researchers have used creep and stress relaxation test data to obtain the Prony series terms that represent the viscoelastic behavior and perform analysis. Others have used dynamic mechanical analysis in order to obtain frequency-domain master curves that were converted to time domain before obtaining the Prony series terms. In this paper, nonlinear solvers were used on frequency domain master curve results from dynamic mechanical analysis to obtain Prony series terms and perform finite element analysis on the impact of adding viscoelastic properties when performing reliability assessment. The computational study results were used to perform a comparative assessment to understand the impact of including viscoelastic behavior in reliability analysis under thermal cycling and drop testing for Wafer Level Chip Scale Packages.
Theoretical Prediction of Laminar Burning Speed of Normal-Decane and Jet Propellant 8
Authors: Lu Zhenyu , Metghalchi Hameed
Published: June 2022

Normal-decane (n-C10H22) is considered as a major component of surrogate for jet and diesel fuels. Jet propellant 8 (JP-8) is a jet fuel which is kerosene-based for gas turbine-powered for aircraft. JP-8 is also considered as fleet fuel. JP-8 has a complex chemical component of higher-order hydrocarbons, including alkanes, cycloalkanes, and aromatic molecules, which makes it hard to develop a chemical kinetics mechanism. In this work, few chemical kinetics mechanisms of n-decane and JP-8 surrogates have been used to model the combustion processes of these fuels in general and determining their burning speed, specifically. The CANTERA freely propagating 1D flame code was used in conjunction with the chemical kinetic mechanism to predict the laminar burning speeds. The theoretical predicted laminar burning speeds have been compared with the experimental laminar burning speed found in the literature.
Imaging of the microstructure of Carbopol dispersions and correlation with their macroelasticity: A micro- and macrorheological study
Authors: Oelschlaeger Claude , Marten Jonas , Péridont Florian , Willenbacher Norbert
Published: June 2022

We developed a new data analysis strategy, the so-called micro-rheo-mapping technique, based on multiparticle tracking experiments to obtain an accurate and direct visualization of the microstructure of commercial acrylate thickeners of Carbopol-type with high (Ultrez 10), intermediate (ETD 2020), and low (ETD 2050) degree of crosslinking. At low polymer concentration, aggregates made of several primary Carbopol particles are formed with an average diameter of 43 ± 11, 56 ± 14, and 10 ± 2.5 μm for Ultrez 10, ETD 2020, and ETD 2050, respectively. For ETD 2050, the least crosslinked thickener, the shell of dangling polymer chains covering the aggregate surface is thicker than for ETD 2020 and Ultrez 10. At technically relevant polymer concentrations, our results indicate, for all three thickeners, that the microstructure is highly heterogeneous with regions of different crosslink densities. One region inaccessible for tracer particles corresponding to a mixture of polydisperse aggregates and individual primary particles with a core mesh size less than 200 nm and a second, diluted enough to be accessible and which exhibits both elastic and viscous characteristics. The study of the impact of pH, polymer concentration, and crosslink density on these local structural and viscoelastic heterogeneities as well as macrorheological properties allowed us to establish a correlation between microstructure and macroelasticity. In particular, we found that the bulk shear modulus strongly depends on the fraction of inaccessible areas, making this microscopic parameter most relevant for describing the macroelasticity of Carbopol gels, whereas the local elasticity of the interstitial regions is of minor importance.
Effectiveness of Augmented Feedback on Drop Landing Using Baseline Vertical Ground Reaction in Female Athletes
Authors: Heinert Becky , Rutherford Drew , Kernozek Thomas W.
Published: June 2022

Context: Targeted training using augmented feedback to influence landing mechanics may be beneficial to athletes. Purpose: Examine how augmented feedback may influence vertical ground reaction force (VGRF) and improve knee valgus in females that display greater VGRF during drop landings. Main Results: Two hundred and forty female athletes participated and were divided into quartiles based on VGRF. Reductions in VGRF and knee valgus were seen across all quartiles with augmented feedback. Greatest reductions were found in the quartile with the largest baseline VGRF. Interpretation: Augmented feedback may be more effective in reducing VGRF and improving knee to ankle ratio in female athletes that have greater baseline VGRF.
The Test–Retest Reliability and Minimal Detectable Change of the FitLight Trainer™
Authors: Myers Lauren R. , Toonstra Jenny L. , Cripps Andrea E.
Published: June 2022

Context: Reaction time is an indicator of cognitive function postconcussion and is an important measurement in return-to-play protocols. Current postconcussion assessments lack evidence regarding their reliability and do not simulate functional movement patterns and choice reactions that occur in sport performance. Objective: This study sought to establish the test–retest reliability of the FitLight Trainer™ in a nonconcussed, healthy population. Methods: Twenty-six healthy individuals from Bowling Green State University participated. Results: Good test–retest reliability was demonstrated for choice reaction time using the FitLight Trainer™ across the two testing sessions (intraclass correlation coefficient [2, 1] = .80). Conclusions: The FitLight Trainer™ provides reliable measures of reaction time in a healthy population.
Patellofemoral Joint Loading in Forward Lunge With Step Length and Height Variations
Authors: Escamilla Rafael F. , Zheng Naiquan , MacLeod Toran D. , Imamura Rodney , Wang Shangcheng , Wilk Kevin E. , Yamashiro Kyle , Fleisig Glenn S.
Published: June 2022

The objective was to assess how patellofemoral loads (joint force and stress) change while lunging with step length and step height variations. Sixteen participants performed a forward lunge using short and long steps at ground level and up to a 10-cm platform. Electromyography, ground reaction force, and 3D motion were captured, and patellofemoral loads were calculated as a function of knee angle. Repeated-measures 2-way analysis of variance (P < .05) was employed. Patellofemoral loads in the lead knee were greater with long step at the beginning of landing (10°–30° knee angle) and the end of pushoff (10°–40°) and greater with short step during the deep knee flexion portion of the lunge (50°–100°). Patellofemoral loads were greater at ground level than 10-cm platform during lunge descent (50°–100°) and lunge ascent (40°–70°). Patellofemoral loads generally increased as knee flexion increased and decreased as knee flexion decreased. To gradually increase patellofemoral loads, perform forward lunge in the following sequence: (1) minimal knee flexion (0°–30°), (2) moderate knee flexion (0°–60°), (3) long step and deep knee flexion (0°–100°) up to a 10-cm platform, and (4) long step and deep knee flexion (0°–100°) at ground level.
Metabolite-Based Mutualistic Interaction between Two Novel Clostridial Species from Pit Mud Enhances Butyrate and Caproate Production
Authors: Sun Hong , Chai Li-Juan , Fang Guan-Yu , Lu Zhen-Ming , Zhang Xiao-Juan , Wang Song-Tao , Shen Cai-Hong , Shi Jin-Song , Xu Zheng-Hong
Published: June 2022

Microbial interactions played crucial roles in influencing the assembly, stability, and function of the microbial community. The metabolites of pit mud microbiota are the key to flavor formation of Chinese strong-flavor baijiu.
Functional Nitrogenase Cofactor Maturase NifB in Mitochondria and Chloroplasts of
Nicotiana benthamiana
Authors: Jiang Xi , Coroian Diana , Barahona Emma , Echavarri-Erasun Carlos , Castellanos-Rueda Rocío , Eseverri Álvaro , Aznar-Moreno Jose A. , Burén Stefan , Rubio Luis M.
Published: June 2022

Biological nitrogen fixation is the conversion of inert atmospheric dinitrogen gas into nitrogen-reactive ammonia, a reaction catalyzed by the nitrogenase enzyme of diazotrophic bacteria and archaea. Because plants cannot fix their own nitrogen, introducing functional nitrogenase in cereals and other crop plants would reduce our strong dependency on N fertilizers.
Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food
Authors: Alotaibi Khulud , Hu Lijun , Revollo Javier , Han Jing , Zhang Guodong , Khan Ashraf A.
Published: June 2022

Shiga toxin-producing
Escherichia coli
(STEC) is a foodborne pathogen transmitted from animal to humans through contaminated food. Here, we report the draft genome sequences of six STEC isolates (six serotypes) from food (cheese, coriander, and pea protein pellets) in different countries; these isolates were resistant to tetracycline, with MIC values ranging from <1.5 to 256 μg/mL.
Comparative Analysis of the Chloroplast Genomes of
Quercus × morehus
and the Presumptive Parents
Q. wislizeni
and
Q. kelloggii
(Fagaceae) from California
Authors: Garcia Alejandro , Katada Althea C. , Serrano Alyssa , Gonzalez-Karlsson Adrea , Carrillo Angel , Castellanos Angelica , Mendez-Gomez Azucena , Flores Carlos J. , Limon Christopher , Lopez Cynthia , Rosas-Uribe Daniela , Hidalgo Dylan J. , Melgarejo Ephraim C. , Estamo Erica L. , Mora Faith , Guzman Gabino , Morones Jason F. , Hughey Jeffery R. , Sanchez-Mendoza Jennifer , Parra Jimena M. , Perez Joaquin , Perez Joe H. , Viorato Arambula Joel , Chavez Juan S. , Figueroa Juan R. , Rodriguez Juan , Cardenas Kevin , Trejo Leslie , Lozano-Ruiz Lizbeth D. , Gonzalez Loreli , Vargas Lorena L. , Trujillo Marc Anthony , Rangel Mariana , Delgado Martin R. , Ibarra-Moreno Mayra A. , Chitica Villalobos Nancy , Corona Priscila , Snowden Quinn , Vargas Roberto , Staretorp Robin B. , Martin Stephanie , Zavala Victor M.
Published: June 2022

Here, we present the complete chloroplast genomes of
Quercus × morehus
,
Q. wislizeni
, and
Q. kelloggii
from California. The genomes are 161,119 to 161,130 bp and encode 132 genes.
Quercus × morehus
and
Q. wislizeni
are identical in sequence but differ from
Q. kelloggii
by three indels and eight SNPs.
The Microbial Community and Functional Potential in the Midland Basin Reveal a Community Dominated by Both Thiosulfate and Sulfate-Reducing Microorganisms
Authors: Tinker Kara , Lipus Daniel , Gardiner James , Stuckman Mengling , Gulliver Djuna
Published: June 2022

The Permian Basin is the largest producing oil and gas region in the United States and plays a critical role supplying national energy needs. Previous work in other basins has demonstrated that the geochemistry and microbiology of hydrocarbon regions can have a major impact on well infrastructure and production.
Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Pseudomonas aeruginosa Isolates
Authors: Montero María Milagro , Domene-Ochoa Sandra , López-Causapé Carla , López-Montesinos Inmaculada , Luque Sonia , Sorlí Luisa , Campillo Núria , Padilla Eduardo , Prim Núria , Ferrer Alapont Lorena , Grau Santiago , Oliver Antonio , Horcajada Juan P.
Published: June 2022

Ceftolozane-tazobactam (C/T) is an antipseudomonal antibiotic with a high clinical impact in treating infection caused by extensively drug-resistant (XDR)
Pseudomonas aeruginosa
isolates, but resistance is emerging. Given its time-dependent behavior, C/T continuous infusion can improve exposure and therefore the pharmacokinetic/pharmacodynamic target attainment.
Natural levees increase in prevalence in the backwater zone: Coastal Trinity River, Texas, USA
Authors: Hassenruck-Gudipati Hima J. , Passalacqua Paola , Mohrig David
Published: June 2022

Flood dynamics in low-relief landscapes control the lateral exchange of water and sediment between a river and its floodplain. Locations where these exchanges occur for any given river discharge depend on local bank elevations, which in turn depend on the type of landform present immediately adjacent to the river channel. Our analysis separated landforms bordering a river into six categories: levee, scroll bar, counter point bar, channel-bend cutoff, erosional surface, and inactive surface. Each landform is associated with a different range of elevations. Levees are the highest, and counter point bars and cutoffs are the lowest. Using a combination of lidar-derived measurements of topography and water-surface profiles derived from U.S. Geological Survey gauge data, we show that landforms at the margins of the river change with downstream position on the coastal reach of the Trinity River in the southern United States. The fractions of counter point bars and cutoffs decrease downstream, while the fraction and continuity of levees increase to nearly 100%. This spatial change correlates with downstream reductions in channel-bend migration and deformation, and the measured range in river stage. As a result, the greatest range in bank elevations occurs upstream where variation in river stage is also highest. Meanwhile, the smallest range in bank elevation and river stage exists in the coastal backwater zone. Our analysis indicates that essentially all levees within the backwater zone are overtopped by flow associated with a single river discharge. Moving upriver, the discharge associated with levee-overtopping flow systematically increases. This study highlights the morphodynamic control on coastal river flooding.
What tests should be used to assess functional performance in youth and young adults following anterior cruciate ligament or meniscal injury? A systematic review of measurement properties for the OPTIKNEE consensus
Authors: Berg Bjørnar , Urhausen Anouk P , Øiestad Britt Elin , Whittaker Jackie L , Culvenor Adam G , Roos Ewa M , Crossley Kay M , Juhl Carsten B , Risberg May Arna
Published: June 2022

Objectives

To critically appraise and summarise measurement properties of functional performance tests in individuals following anterior cruciate ligament (ACL) or meniscal injury.

Design

Systematic review.

Data sources

Systematic searches were performed in Medline (Ovid), Embase (Ovid), CINAHL (EBSCO) and SPORTSDiscus (EBSCO) on 7 July 2021.

Eligibility criteria for selecting studies

Studies evaluating at least one measurement property of a functional performance test including individuals following an ACL tear or meniscal injury with a mean injury age of ≤30 years. The COnsensus-based Standards for the selection of health Measurement INstruments Risk of Bias checklist was used to assess methodological quality. A modified Grading of Recommendations Assessment, Development and Evaluation assessed evidence quality.

Results

Thirty studies evaluating 26 functional performance tests following ACL injury were included. No studies were found in individuals with an isolated meniscal injury. Included studies evaluated reliability (n=5), measurement error (n=3), construct validity (n=26), structural validity (n=1) and responsiveness (n=1). The Single Leg Hop and Crossover Hop tests showed sufficient intrarater reliability (high and moderate quality evidence, respectively), construct validity (low-quality and moderate-quality evidence, respectively) and responsiveness (low-quality evidence).

Conclusion

Frequently used functional performance tests for individuals with ACL or meniscal injury lack evidence supporting their measurement properties. The Single Leg Hop and Crossover Hop are currently the most promising tests following ACL injury. High-quality studies are required to facilitate stronger recommendations of performance-based outcomes following ACL or meniscal injury.
Stroke thrombectomy perioperative anesthetic and hemodynamic management
Authors: Farag Ehab , Argalious Maged , Toth Gabor
Published: June 2022

There is an ongoing debate about the optimal anesthetic and hemodynamic management of acute stoke patients with large vessel occlusion undergoing endovascular mechanical thrombectomy. Several prospective and retrospective analyses, and randomized controlled trials, attempted to address the challenges of using different anesthetic modalities in acute stroke patients requiring mechanical thrombectomy. We review the advantages and disadvantages of monitored anesthesia care, local anesthesia, conscious sedation, and general anesthesia, along with the relevance of hemodynamic management and perioperative oxygenation status in these complex patients.
Patient risk screening to improve transitions of care in surgical opioid prescribing: a qualitative study of provider perspectives
Authors: Hinds Shelby , Miller Jacquelyn , Maccani Merissa , Patino Sarah , Kaushal Shivani , Rieck Heidi , Walker Monica , Brummett Chad M , Bicket Mark C , Waljee Jennifer F
Published: June 2022

Introduction

In patients undergoing surgical procedures, transitions in opioid prescribing occur across multiple providers during the months before and after surgery. These transitions often result in high-risk and uncoordinated prescribing practices, especially for surgical patients with prior opioid exposure. However, perspectives of relevant providers about screening and care coordination to address these risks are unknown.

Methods

We conducted qualitative interviews with 24 surgery, primary care, and anesthesia providers in Michigan regarding behaviors and attitudes about screening surgical patients to inform perioperative opioid prescribing in relation to transitions of care. We used an interpretive description framework to topically code interview transcripts and synthesize underlying themes in analytical memos.

Results

Providers believed that coordinated, multidisciplinary approaches to identify patients at risk of poor pain and opioid-related outcomes could improve transitions of care for surgical opioid prescribing. Anesthesia and primary care providers saw value in knowing patients’ preoperative risk related to opioid use, while surgeons’ perceptions varied widely. Across specialties, most providers favored a screening tool if coupled with actionable recommendations, sufficient resources, and facilitated coordination between specialties. Providers identified a lack of pain specialists and a dearth of actionable guidelines to direct interventions for patients at high opioid-related risk as major limitations to the value of patient screening.

Discussion

These findings provide context to address risk from prescription opioids in surgical transitions of care, which should include identifying high-risk patients, implementing a coordinated plan, and emphasizing actionable recommendations.
Electronic, optical and thermoelectric properties of MoS2-GaN interface
Authors: Dezfuli Firouzeh Motamad , Boochani Arash , Parhizgar Sara Sadat , Darabi Elham
Published: June 2022

Based on the density functional theory (DFT), the electronic, optical and thermoelectric properties of the MoS2-GaN interface at three different distances have been investigated. In all configurations, we see the semiconductor behavior at the MoS2-GaN interface. Their direct bandgaps at the MoS2-GaN interface with 2.8782, 4.0870 and 5.3330 [Formula: see text] distances are 1.50, 1.12 and 1.15 eV, respectively. The optical properties of these structures were investigated with three Random Phase Approximation (RPA), Time-Dependent Density Functional Theory (TDFT) and Bethe-Salpeter Equation (BSE) approximations, and their semiconductor properties were confirmed, especially with the BSE one.
Simulation of adult-child matching behavior: A case study of primary school in Linyi city, China
Authors: Li Yongxing , Yang Xiaoxia , Gu Xin , Chen Yanyan
Published: June 2022

Pedestrian evacuation at the gate of primary school after school is always a tricky question bothering us. In order to improve the safety and efficiency of pedestrian evacuation at the gate of primary school, adult–child matching behavior after school is analyzed. We propose four adult–child matching strategies considering order or random of adults and children in the matching process. Fusing the matching strategy into a cellular automata (CA)-based pedestrian simulation model and taking the Linyi No. 40 middle school, China as the case study, the adult–child matching behavior is simulated on the platform of MATLAB software. The simulation results indicate that evacuation efficiency of the strategy (adults are orderly distributed in the first waiting area and children are orderly queuing up) reaches the maximum value among the four strategies. Effective matching strategies could reduce pedestrian conflicts. The randomly children and randomly adults are all the negative impacts for evacuation. Orderly evacuation process could reduce pedestrian conflicts. Compared with the randomly children, the effect on evacuation efficiency of the randomly adults is larger. A reasonable number of evacuated pedestrians at a time could improve the whole evacuation efficiency, and we advise the Linyi No. 40 middle school to evacuate three classes at a time.
Conceptualizing Green Strategies’ Effects on Customer Experience in the Context of Omnichannel Retailing
Authors: Sfakianaki Emmanouela , Vrechopoulos Adam , Lazaris Chris
Published: June 2022

The continuous adoption of environmental sensitive strategies in the context of strategic marketing planning along with the wide diffusion of omnichannel business practices raised challenging research issues towards shedding more light on the mechanics through which such business attempts affect consumer behavior. In parallel, the growing academics’ and practitioners’ interest on measuring the overall customer experience across channels fuel the research need to investigate how customer experience is affected in the context of a continuously evolving business landscape. To this end, this study attempts to conceptualize the effects of green strategies on customer experience in the context of omnichannel retailing though the development of an interdisciplinary conceptual model positioned in the fields of Marketing and Electronic Commerce. For that purpose, the study thoroughly reviews the relevant literature and formulates direct research questions supported by theoretical insights and evolving business practices which are reflected on the interrelationships of the derived conceptual model. This paper provides direct implications for research, as well as some straightforward managerial implications.
Financial Reporting Quality and Private Firms’ Access to Trade Credit Capital
Authors: Elemes Anastasios , Filip Andrei
Published: June 2022

The research problem

We examine the association between financial reporting quality and trade credit capital for a large sample of European private firms. Furthermore, we explore how information asymmetry and credit rationing moderate the link between financial reporting quality and trade credit financing.

Motivation

Trade credit constitutes one of the most important sources of financing for private firms. Nevertheless, prior research has provided few and inconclusive evidence of the link between financial reporting quality and private firms’ trade credit capital. Our study is further motivated by the recent calls for more research on the determinants of the relation between financial reporting quality and trade credit financing (e.g., Hope & Vyas ( 2017 )).

The test hypotheses

H1: There is a positive association between financial reporting quality and private firms’ access to trade credit capital.

H2a: The relation between financial reporting quality and private firms’ access to trade credit capital is more positive when information asymmetry and uncertainty about future cash flows are high.

H2b: The relation between financial reporting quality and private firms’ access to trade credit capital is more positive when credit is rationed.

Target population

Policymakers who seek to improve accounting standards and customize them to the financial reporting needs of private firms and their stakeholders (e.g., international financial reporting standards for small and medium-sized enterprises), private firm managers, and private firm suppliers.

Adopted methodology

Ordinary Least Squares regression analyses.

Analyses

We examine the association between financial reporting quality and trade credit financing for a large sample of private firms from Europe’s five largest economies, i.e., France, Germany, Italy, Spain, and the United Kingdom. Our sample period spans from 2010 to 2016. We use the Amadeus database as our source of data. We regress trade credit capital on three proxies for financial reporting quality. In cross-sectional analyses, we repeat our main estimations by interacting our proxies for financial reporting quality with proxies for information asymmetry and credit rationing.

Findings

We find strong evidence that high-quality financial reporting is associated with more trade credit financing in private firms. We further show that the positive relation between high-quality financial reporting and trade credit is stronger when information asymmetry and uncertainty about future cash flows is high as well as when credit is rationed. These findings suggest that suppliers complement insider communication channels and financial reporting quality and provide a more nuanced understanding of the interplay among information asymmetry, credit rationing, and trade credit financing.