bluuebunny/crossref_metadata_2025 huggingface dataset:
Secure Token–Key Implications in an Enterprise Multi-Tenancy Environment Using BGV–EHC Hybrid Homomorphic Encryption
Authors: Dhiman Pooja , Henge Santosh Kumar , Ramalingam Rajakumar , Dumka Ankur , Singh Rajesh , Gehlot Anita , Rashid Mamoon , Alshamrani Sultan S. , AlGhamdi Ahmed Saeed , Alshehri Abdullah
Published: June 2022

Authentication, authorization, and data access control are playing major roles in data security and privacy. The proposed model integrated the multi-factor authentication–authorization process with dependable and non-dependable factors and parameters based on providing security for tenants through a hybrid approach of fully homomorphic encryption methodology: the enhanced homomorphic cryptosystem (EHC) and the Brakersky–Gentry–Vaikuntanathan (BGV) scheme. This research was composed of four major elements: the fully homomorphic encryption blended schemes, EHC and BGV; secure token and key implications based on dependable and don-dependable factors; an algorithm for generating the tokens and the suitable keys, depending on the user’s role; and the execution of experimental test cases by using the EHC algorithm for key and token generation, based on dependable and non-dependable parameters and time periods. The proposed approach was tested with 152 end-users by integrating six multi-tenants, five head tenants, and two enterprise levels; and achieved a 92 percent success rate. The research integrated 32-bit plain text in the proposed hybrid approach by taking into consideration the encryption time, decryption time, and key generation time of data transmission via cloud servers. The proposed blended model was efficient in preventing data from ciphertext attacks and achieved a high success rate for transmitting data between the multi-tenants, based on the user-role-user type of enterprise cloud servers.
The Diversification and Enhancement of an IDS Scheme for the Cybersecurity Needs of Modern Supply Chains
Authors: Deyannis Dimitris , Papadogiannaki Eva , Chrysos Grigorios , Georgopoulos Konstantinos , Ioannidis Sotiris
Published: June 2022

Despite the tremendous socioeconomic importance of supply chains (SCs), security officers and operators are faced with no easy and integrated way for protecting their critical, and interconnected, infrastructures from cyber-attacks. As a result, solutions and methodologies that support the detection of malicious activity on SCs are constantly researched into and proposed. Hence, this work presents the implementation of a low-cost reconfigurable intrusion detection system (IDS), on the edge, that can be easily integrated into SC networks, thereby elevating the featured levels of security. Specifically, the proposed system offers real-time cybersecurity intrusion detection over high-speed networks and services by offloading elements of the security check workloads on dedicated reconfigurable hardware. Our solution uses a novel framework that implements the Aho–Corasick algorithm on the reconfigurable fabric of a multi-processor system-on-chip (MPSoC), which supports parallel matching for multiple network packet patterns. The initial performance evaluation of this proof-of-concept shows that it holds the potential to outperform existing software-based solutions while unburdening SC nodes from demanding cybersecurity check workloads. The proposed system performance and its efficiency were evaluated using a real-life environment in the context of European Union’s Horizon 2020 research and innovation program, i.e., CYRENE.
Structure Optimization of Academic Disciplines for Universities Featuring Energy under the Roadmap towards Carbon Neutrality: Results from a Hybrid Fuzzy-Based Method
Authors: Wang Bing , Li Lu , Deng Kailei , Ge Haotian , Liu Hanchen
Published: June 2022

The goal of carbon neutrality is an extensive and profound economic and social change, which will have far-reaching impacts on industrial structure, energy structure, and social consumption structure. Energy sectors will face in-depth adjustment, and it is essential to optimize major structures consequently due to the foresight of talent training. This research first employs Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis, Analytic Network Process (ANP), and the weighted fuzzy Technique for Order Performance by Similarity to Ideal Solutions (TOPSIS) to formulate and analyze the structure optimization of academic disciplines, and finally, the universities featuring mining are taken as an example to verify the feasibility of the method. Results reveal that the integration of ANP, SWOT, and the fuzzy TOPSIS evaluation method is able to qualify the assessment for academic discipline optimization. The specialty structure optimization results should focus on clean, intelligent, and sustainable development of the coal industry. The first priority is to increase relevant research on sustainable development of the mining industry, with a priority value of 0.0435. The modern coal chemistry and intelligent coal mining are also highly valued as the options for achieving carbon neutrality. Adding natural gas-related majors is underestimated as the least recognized priority, with a priority value of 0.0133. Suggestions and implications are provided for structure optimization of academic disciplines in universities featuring energy.
Plasma-Deposited Fluorocarbon Coatings on Methylammonium Lead Iodide Perovskite Films
Authors: Armenise Vincenza , Colella Silvia , Milella Antonella , Palumbo Fabio , Fracassi Francesco , Listorti Andrea
Published: June 2022

Metal halide perovskites are excellent semiconductors materials that can be exploited in many fields, from the vastly explored photovoltaics to the recent applications in photocatalysis. One of the material’s known limitations is the poor resistance to moisture which induces degradation, triggered by the soft and defective nature of its surface. In this study, we explore non-equilibrium plasmas, to deposit a fluorocarbon polymer on the surface of a MAPbI3 film. We found that the treatment generally enhances the film stability over time, and in certain conditions it improves the perovskite optical properties, demonstrating to be a good strategy aiming defects passivation. Thanks to the solvent-free and non-invasive nature of plasmas, this technique has the potential to be extensively applied to a wide range of perovskite materials targeting different applications.
Analysis of the Impact of the COVID-19 Pandemic on the Value of CO2 Emissions from Electricity Generation
Authors: Jaroń Agata , Borucka Anna , Parczewski Rafał
Published: June 2022

The study analyzed the impact of the COVID-19 pandemic on the carbon dioxide emissions from electricity generation. Additionally, monthly seasonality was taken into account. It was assumed (research hypothesis) that both the COVID-19 pandemic (expressed in individual waves of infection cases) and the month have a significant impact on CO2 emissions. Analysis of variance (ANOVA) and non-parametric Kruskal–Wallis tests were used to evaluate the significance of the influence of individual explanatory variables on the CO2 emission. The identification of the studied series (CO2 emission) was first made by means of a linear regression model with binary variables and then by the ARMAX model. The analysis shows that in the consecutive months and periods of the COVID-19 pandemic, CO2 emissions differ significantly. The highest increase in emissions was recorded for the second wave of the pandemic, as well as in January and February. This is due to the overlapping of both the increase in infections (favoring stays at home) and the winter season. It can be concluded that working plants, schools and factories had the same demand for electricity, but sources of increased consumption were people staying at home and in hospitals as a result of deteriorated health, isolation or quarantine.
A Rising Role for Decentralized Solar Minigrids in Integrated Rural Electrification Planning? Large-Scale, Least-Cost, and Customer-Wise Design of Grid and Off-Grid Supply Systems in Uganda
Authors: González-García Andrés , Ciller Pedro , Lee Stephen , Palacios Rafael , de Cuadra García Fernando , Pérez-Arriaga José Ignacio
Published: June 2022

Increasing Uganda’s low electrification rate is one of the country’s major challenges. Power service is essential to achieve socioeconomic development and poverty reduction, especially in rural areas. This paper shows the advantages of using an integrated (grid and off-grid) electrification model with high geospatial, temporal, and customer-class granularity as the Reference Electrification Model (REM). In universal electrification strategies, REM will help better ascertain the role of minigrids, jointly with grid extension, solar kits, and stand-alone systems. REM has been applied to the Southern Service Territory (SST) to determine the least-cost mix of electrification modes—grid extension, off-grid minigrids, and standalone systems—that satisfies the hourly demand requirements of each customer—residential, commercial, or industrial—considering its individual location. REM incorporates the existing grid layout, the hourly solar local profile, and the catalogs of actual components for network and generation designs. The paper shows that minigrids can provide grid-like service at a significantly lower cost in many circumstances and to a considerable extent. Therefore, minigrid strategies should play a more important role in electrification planning, both transitorily and on a permanent basis, particularly when the central grid suffers from frequent and prolonged blackouts.
Experiment-Based Study of Heat Dissipation from the Power Cable in a Casing Pipe
Authors: Masnicki Romuald , Mindykowski Janusz , Palczynska Beata
Published: June 2022

The paper deals with the important challenges in terms of electricity transmission by means of underground cable lines. The power cable’s performance is characterized by an ampacity that represents its maximum electric current-carrying capacity. The ampacity of power cables depends on their ability to diffuse the heat generated by the current flow into the environment. In the performed research, the analysis of the efficiency of heat dissipation from the cable is based on the measurement of temperatures at selected points in individual sections of the cable. As a consequence, the proposed test stand and applied research methodology are vital for the experimental evaluation of the analyzed thermal phenomena in the investigated underground cable lines. The research program covers an in-depth analysis based on the results related to the vital parameters of the investigated cable. The experimental methodology was used to analyze the influence of the properties of the medium surrounding the cable on its temperature, and thus on the ampacity of the cable. A novelty of this paper concerns the carrying out of the experimental laboratory research with actual measurements of the temperature distribution in specific points of the casing pipe based on the original test stand. The paper presents the novel concept of the developed stand for testing heat dissipation from the cable in a casing pipe with pipe sections filled with various media, equipped with a power supply system ensuring easy control of the power dissipated in the cable. The preliminary results of the comparative tests, in which the temperature distribution in the sections of the casing pipes was recorded, indicate that the findings are satisfactorily consistent with the assumptions related to the purpose of the research. The use of appropriate materials surrounding the cable contributes to more effective heat dissipation, and as it has been shown for the examined case in originally planned and conducted tests, it can lower the cable temperature by more than 20 °C, contributing to a significant increase in the ampacity of the cable. For example, it was recorded that for different media filling the pipes, the cable reached 30 °C with different currents flowing through cable of 60 A and 120 A, respectively.
Scenarios on the Impact of Electric Vehicles on Distribution Grids
Authors: Borenius Seppo , Tuomainen Petri , Tompuri Jyri , Mansikkamäki Jesse , Lehtonen Matti , Hämmäinen Heikki , Kantola Raimo
Published: June 2022

The electricity sector has a central role in the efforts to meet climate targets. Consequently, efforts are taking place to electrify industry, heating, and transportation. The Finnish government has set the target to halve carbon dioxide traffic emissions by 2030 and achieve carbon neutrality by 2045. Due to this target, the currently small proportion of electric vehicles (EVs) in Finland could expand in a manner that is difficult to forecast but could be exponential. Amid already strained investment budgets, anticipating the alternative scenarios and impacts of such a transport electrification evolution is of high importance to distribution system operators in order to optimize network planning and enhancements during the coming 15–25 years. The novelty and contribution of this paper is in utilizing a formal scenario planning process to envision what the alternative scenarios are (i.e., possible futures) for the evolution of the electric car fleet in Finland until 2040 and how these alternative scenarios could impact distribution grids. The impact analysis is performed in terms of additional energy and additional power in order to gain an understanding of the high-level impacts and investment needs. The analysis utilizes a real distribution grid in southern Finland as a case example that enables quantification. The results indicate the electric vehicles will, depending the scenario, pose an essential additional load in terms of both energy and power and that the required investment levels and investment types will be heavily dependent on the scenario.
Ionic Liquid and Ionanofluid-Based Redox Flow Batteries—A Mini Review
Authors: Joseph Aswathy , Sobczak Jolanta , Żyła Gaweł , Mathew Suresh
Published: June 2022

Stationary energy storage methods such as flow batteries are one of the best options to integrate with smart power grids. Though electrochemical energy storage using flow battery technologies has been successfully demonstrated since the 1970s, the introduction of ionic liquids into the field of energy storage introduces new dimensions in this field. This reliable energy storage technology can provide significantly more flexibility when incorporated with the synergic effects of ionic liquids. This mini-review enumerates the present trends in redox flow battery designs and the use of ionic liquids as electrolytes, membranes, redox couples, etc. explored in these designs. This review specifically intends to provide an overview of the research prospects of ionic liquids for redox flow batteries (RFB).
A Formative Study of the Implementation of Whole Genome Sequencing in Northern Ireland
Authors: Kerr Katie , McKenna Caoimhe , Heggarty Shirley , Bailie Caitlin , McMullan Julie , Crowe Ashleen , Kilner Jill , Donnelly Michael , Boyle Saralynne , Rea Gillian , Flanagan Cheryl , McKee Shane , McKnight Amy Jayne
Published: June 2022

Background: The UK 100,000 Genomes Project was a transformational research project which facilitated whole genome sequencing (WGS) diagnostics for rare diseases. We evaluated experiences of introducing WGS in Northern Ireland, providing recommendations for future projects. Methods: This formative evaluation included (1) an appraisal of the logistics of implementing and delivering WGS, (2) a survey of participant self-reported views and experiences, (3) semi-structured interviews with healthcare staff as key informants who were involved in the delivery of WGS and (4) a workshop discussion about interprofessional collaboration with respect to molecular diagnostics. Results: We engaged with >400 participants, with detailed reflections obtained from 74 participants including patients, caregivers, key National Health Service (NHS) informants, and researchers (patient survey n = 42; semi-structured interviews n = 19; attendees of the discussion workshop n = 13). Overarching themes included the need to improve rare disease awareness, education, and support services, as well as interprofessional collaboration being central to an effective, mainstreamed molecular diagnostic service. Conclusions: Recommendations for streamlining precision medicine for patients with rare diseases include administrative improvements (e.g., streamlining of the consent process), educational improvements (e.g., rare disease training provided from undergraduate to postgraduate education alongside genomics training for non-genetic specialists) and analytical improvements (e.g., multidisciplinary collaboration and improved computational infrastructure).
Characterization of Expression and Epigenetic Features of Core Genes in Common Wheat
Authors: Zheng Dongyang , Zhang Wenli
Published: June 2022

The availability of multiple wheat genome sequences enables us to identify core genes and characterize their genetic and epigenetic features, thereby advancing our understanding of their biological implications within individual plant species. It is, however, largely understudied in wheat. To this end, we reanalyzed genome sequences from 16 different wheat varieties and identified 62,299 core genes. We found that core and non-core genes have different roles in subgenome differentiation. Meanwhile, according to their expression profiles, these core genes can be classified into genes related to tissue development and stress responses, including 3376 genes highly expressed in both spikelets and at high temperatures. After associating with six histone marks and open chromatin, we found that these core genes can be divided into eight sub-clusters with distinct epigenomic features. Furthermore, we found that ca. 51% of the expressed transcription factors (TFs) were marked with both H3K27me3 and H3K4me3, indicative of the bivalency feature, which can be involved in tissue development through the TF-centered regulatory network. Thus, our study provides a valuable resource for the functional characterization of core genes in stress responses and tissue development in wheat.
Challenges Assessing Rock Slope Stability Using the Strength Reduction Method with the Hoek–Brown Criterion on the Example of Vals (Tyrol/Austria)
Authors: Illeditsch Mariella , Preh Alexander , Sausgruber Johann Thomas
Published: June 2022

To estimate the hazard posed by rock slopes, it is essential to determine the overall stability and potential detachment volume. This is mostly solved using numerical methods together with the strength reduction method (SRM). Many calculation programs do not provide a direct implementation of the Hoek–Brown (HB) criterion. Equivalent Mohr–Coulomb (MC) parameters are often used. Especially for steep rock slopes, the use of equivalent MC parameters with numerical codes and the SRM lead to poor estimates of safety factors. The problem lies in the required and often difficult estimation of a suitable range of minor principal stresses over a ‘slope height’. In the example of the stability analysis of the rock slope Vals in Tyrol/Austria, we show the differences between the application of equivalent MC parameters and a direct application of the HB criterion with apparent MC parameters. The detachment volume and stability are overestimated when applying equivalent MC parameters, as confirmed by calculations with the continuum mechanics code FLAC3D (Itasca Consulting Group). However, the SRM with HB material (i.e., apparent MC parameters) results in a safety factor that cannot be applied to HB parameters. To date, it has not been possible to determine the HB parameters for limit equilibrium via the SRM. This challenge was overcome by fitting an HB envelope to the original HB shear envelope reduced by the safety factor. The envelope is adjusted by two HB variables: GSI and D. This allows to determine the HB parameters at limit equilibrium. It helps to make more realistic predictions about the detachment mechanism and volume.
Kinematic and Geometric Characterization of the Vögelsberg Rockslide (Tyrol, Austria) by Means of MT-InSAR Data
Authors: Vecchiotti Filippo , Amabile Anna Sara , Clemente Salvatore , Ostermann Marc , Nicodemo Gianfranco , Peduto Dario
Published: June 2022

This paper focuses on the study of the Vögelsberg landslide located in the municipality of Wattens (Tyrol, Austria), which reactivated in 2016, causing damages to nearby buildings and infrastructures. Since the date of reactivation, a modern monitoring system has been implemented with the installation of in-situ geodetic automated tracking total stations (ATTS), an inclinometer and two piezometers. Here, we describe two distinctive methods, the Breaks for Additive Seasonal and Trend (BFAST) and the Vector Inclination Method (VIM) used to characterize the landslide from the kinematic and geometrical point of view. The main input data, used for both methods, derive from processing a stack of several Sentinel-1 differential interferograms with the Multiple Small Baseline Subset (MSBAS) 2D and 3D algorithms. BFAST allowed highlighting the seasonality of the phenomenon from the analysis of the time series as well as the trend and the breakpoints that identify the landslide reactivation phases. These latter were then correlated with the main triggering factors such as rain and snow melting. The application of the VIM through the exploitation of the MSBAS displacement vectors allowed the reconstruction of the depth of the landslide slip surface along both the longitudinal and transversal direction and, in turn, the evaluation of the volumes of material mobilized by the landslide. The results obtained further prove that procedures for the in-depth analysis of Multi-Temporal Interferometric Synthetic Aperture Radar (MT-InSAR) data can contribute to slow-moving landslide characterization, which represents a fundamental step for landslide hazard assessment within quantitative risk analyses.
Comment on Laroche, E.; L’Espérance, S. Cancer Incidence and Mortality among Firefighters: An Overview of Epidemiologic Systematic Reviews. Int. J. Environ. Res. Public Health 2021, 18, 2519
Authors: Guidotti Tee
Published: June 2022

This is a letter to the Editor critiquing Laroche and L’Esperance, “Cancer Incidence and Mortality among Firefighters: An Overview of Epidemiologic Systematic Reviews” [...]
Do Improvements in Maternal Mental Health Predict Improvements in Parenting? Mechanisms of the Mindful with Your Baby Training
Authors: Potharst Eva S. , Kuijl Manon , Wind Daphne , Bögels Susan M.
Published: June 2022

Postpartum mental health symptoms are associated with parenting difficulties, which have negative consequences for child development. Interventions for young mothers should target their mental health problems and parenting difficulties. Mindful with Your Baby (MwyB) is an intervention for parents, with a baby, who experience (mental) health problems and/or stress or insecurity in parenting. This study seeks to replicate previous effects of MwyB regarding mindfulness, mindful parenting, maternal (mental) health (psychological distress, depressive mood, physical health complaints) and parenting outcomes (parenting stress, parental self-efficacy, bonding), and gain insight into the working mechanisms of the training. Mothers with babies aged 1–18 months (n = 61) completed questionnaires at waitlist, pretest, posttest, and 8-week follow-up. No significant differences were seen between the waitlist and pretest. Significant improvements in all outcomes were shown in the posttest (except for physical health complaints) and follow-up, compared to the pretest. Improvements in depressive symptoms and physical health complaints were dependent on improvements in mindfulness. Improvements in parental self-efficacy were dependent on improvements in mindful parenting. Improvements in some (mental) health and parenting outcomes seemed to be bidirectional. The results suggest that both mindfulness and mindful parenting are important for mothers who experience psychological distress and/or stress or insecurity in parenting their babies.
Falls and Preventive Practices among Institutionalized Older People
Authors: Baixinho Cristina Lavareda , Madeira Carla , Alves Silvia , Henriques Maria Adriana , Dixe Maria dos Anjos
Published: June 2022

The present study about falls among the older adult population essentially explores bio-physiological factors. In light of the complexity of the factors that cause these accidents, it is important to identify the safety and self-care practices of institutionalized older adults and their relationship with falls in order to introduce prevention measures and personalized cognitive–behavioral strategies. The objective of this study was to: (a) determine the frequency of falls and their recurrence among institutionalized older adults, and (b) to associate the occurrence of falls among institutionalized adults with or without cognitive impairment to communication and safety practices. This was a quantitative, correlational, and longitudinal study with 204 institutionalized older adults living in two long-term care facilities in Portugal. The Scale of Practices and Behaviors for Institutionalized Elderly to Prevent Falls was administered to the sample. The prevalence of falls at a 12-month follow-up was 41.6%, of which 38.3% were recurring episodes. Older adults with cognitive decline showed lower mean scores for safety practices. Further research with larger samples should explore the relationships between communication and safety practices and falls, their recurrence, and fear of new falls.
Effect of Cloth Masks and N95 Respirators on Maximal Exercise Performance in Collegiate Athletes
Authors: Darnell Matthew E. , Quinn Tyler D. , Carnahan Sean P. , Carpenter Tyler , Meglino Nicholas , Yorio Patrick L. , Doperak Jeanne M.
Published: June 2022

This study compared exercise performance and comfort while wearing an N95 filtering facepiece respirator (N95), cloth mask, or no intervention control for source control during a maximal graded treadmill exercise test (GXT). Twelve Division 1 athletes (50% female, age = 20.1 ± 1.2, BMI = 23.5 ± 1.6) completed GXTs under three randomized conditions (N95, cloth mask, control). GXT duration, heart rate (HR), respiration rate (RR), transcutaneous oxygen saturation (SpO2), transcutaneous carbon dioxide (TcPCO2), rating of perceived exertion (RPE), and perceived comfort were measured. Participants ran significantly longer in control (26.06 min) versus N95 (24.20 min, p = 0.03) or cloth masks (24.06 min, p = 0.04). No differences occurred in the slope of HR or SpO2 across conditions (p > 0.05). TcPCO2 decreased faster in control (B = −0.89) versus N95 (B = 0.14, p = 0.02) or cloth masks (B = −0.26, p = 0.03). RR increased faster in control (B = 8.32) versus cloth masks (B = 6.20, p = 0.04). RPE increased faster in the N95 (B = 1.91) and cloth masks (B = 1.79) versus control (B = 1.59, p < 0.001 and p = 0.05, respectively). Facial irritation/itching/pinching was higher in the N95 versus cloth masks, but sweat/moisture buildup was lower (p < 0.05 for all). Wearing cloth masks or N95s for source control may impact exercise performance, especially at higher intensities. Significant physiological differences were observed between cloth masks and N95s compared to control, while no physiological differences were found between cloth masks and N95s; however, comfort my differ.
Land Use Transition and Eco-Environmental Effects in Karst Mountain Area Based on Production-Living-Ecological Space: A Case Study of Longlin Multinational Autonomous County, Southwest China
Authors: Wang Min , Qin Kongtao , Jia Yanhong , Yuan Xiaohan , Yang Shuqi
Published: June 2022

The linkage mechanisms and optimization strategies between land use transition and eco-environmental effects that occur in the production-living-ecological space of karst mountain areas remain under-explored in the current literature. Based on county data collected in Longlin Multinational Autonomous County of Guangxi, which is located in the rocky desertification area of Yunnan, Guangxi, and Guizhou, this study contributes a county-level analysis on land use transition and eco-environmental effects by addressing two research questions: (1) Which factors of land use transition are related to the eco-environmental effects of production-living-ecological space? (2) What are the key land allocation mechanisms behind the interventions of local rocky desertification regulation policies? We conducted two sets of analyses to answer these two questions: quantitative analyses of the spatial and temporal evolution between land use transition, rocky desertification, and its eco-environmental effects, and qualitative analyses of policy interventions on production-living-ecological land development and rocky desertification management. The findings show that the occurrence of rocky desertification accompanied by unreasonable land use structure transition and its important factor is caused by ecological land being restricted by production-living land. Specifically, urbanization strategies coordinating ecological and socio-economic effects is significant to karst mountain areas. Moreover, the orderly increase of woodland slows down rocky desertification. Policies of “returning farmland to forest” and “afforestation of wasteland” have significantly reduced rocky desertification that can be applied to other geographical situations.
Study on the Impact of Income Gap on Health Level of Rural Residents in China
Authors: Guo Hongpeng , Yang Yang , Pan Chulin , Xu Shuang , Yan Nan , Lei Qingyong
Published: June 2022

With the rapid development of the social economy, health has increasingly become the focus of attention. Therefore, based on the balanced panel data of the China Household Tracking Survey (CFPS) from 2010 to 2018, the Probit model was used to investigate the impact of the income gap in rural areas on residents’ health level, and the relevant influencing mechanism was discussed in this paper. Results: (1) The income gap has a significant negative effect on the health level of rural residents, and the expansion of the income gap will have a more significant impact on the health level of rural residents. (2) The income gap will restrain the health level of rural residents by affecting the family income level and mobility constraints. (3) The restraining effect of the income gap on health formation mainly affects the families of young rural residents, rural male residents, residents with no rental income, and residents with low social capital. This paper analyzes and discusses, from the perspective of income gap, the impact of the income gap on the health status of rural residents in China. Based on the above conclusions, this paper puts forward some feasible suggestions to improve the health level of rural residents.
Effects of Active Breaks on Physical Literacy: A Cross-Sectional Pilot Study in a Region of Spain
Authors: Mendoza-Muñoz María , Calle-Guisado Violeta , Pastor-Cisneros Raquel , Barrios-Fernandez Sabina , Rojo-Ramos Jorge , Vega-Muñoz Alejandro , Contreras-Barraza Nicolás , Carlos-Vivas Jorge
Published: June 2022

Several studies have shown that active breaks (AB) lead to improvements in physical fitness, daily steps taken and participants’ health. However, there are no studies that have evaluated how they affect physical literacy (PL). Aims: Therefore, this study examined the effects of a 4-week recreational AB program based on games whose main objective was to improve motivation and motor skills’ improvement in PL in schoolchildren. Method: A quasi-experimental pilot study was conducted with PL assessments before and after a 4-week recreational AB program. Results: Fifty-seven schoolchildren (10.28 ± 0.43 years) participated in the study, 29 in the control group and 28 in the experimental group. An improvement in PL was found between the experimental and control groups after the intervention (p = 0.017). Moreover, the experimental group also improved (p < 0.001) PL after the intervention. More specifically, within the domain of PL, improvements were found after the intervention in the experimental group in the domains of physical competence (p < 0.001), motivation and confidence (p < 0.001) and knowledge (p < 0.001) but not in the domain of daily activity (p = 0.051). Conclusion: The application of an AB program based on playful games, during four weeks, produced an increase in scores in the general PL level, as well as in the domains of physical competence, motivation, and knowledge and understanding in schoolchildren.
Thailand Achievement of SDG Indicator 4.2.1 on Early Child Development: An Analysis of the 2019 Multiple Indicator Cluster Survey
Authors: Topothai Thitikorn , Suphanchaimat Rapeepong , Topothai Chompoonut , Tangcharoensathien Viroj , Cetthakrikul Nisachol , Waleewong Orratai
Published: June 2022

The early years of a child’s life are the foundation for their future capability development. Poor health, hunger, poverty, low parental education, lack of parental interaction, high screen time, and poor housing environment hamper their development. There is little evidence of a link between early child development (ECD) and sociodemographic factors in Thailand. In response to monitoring the achievement of SDG target 4.2.1 (the proportion of young children who are developmentally on track in health, learning and psychosocial well-being) as required by all UN Member States, this study analyses the prevalence of appropriate levels of ECD and its correlates of Thai children aged 3 to 4 years. A cross-sectional study of the 6th Multiple Indicator Cluster Survey (MICS) data in 2019 conducted by the National Statistical Office was employed. Face-to-face interviews with mothers and/or legal guardians were conducted. A total of 5787 children aged 3 to 4 were enrolled in this study. The majority of participants, approximately 92.3%, had achieved an appropriate level of ECD index, defined as children who were developmentally on track in at least three out of these four domains: cognitive, physical, social, and learning. Multivariate logistic regression showed that girls had a higher appropriate development index than boys (Adjusted Odds Ratio [AOR] = 1.56, 95% Confidence Interval [95% CI] 1.28–1.90; children living in the 5th wealth quintile had a higher appropriate index than those in a less well-off family the first wealth quintile (AOR = 2.92, 95% CI: 1.86–4.58. Univariate logistic regression showed children living with parents achieving post-secondary education had a significantly greater appropriate index than children living with parents completing secondary education or below (Crude OR = 1.95, 95% CI 1.47–2.58); children who had appropriate parental interactions of more than four out of six interactions, had a significantly higher chance of having an appropriate index than less than four interactions (Crude OR = 1.52, 95% CI 1.14–2.04). Multi-sectoral policies to support child development in low socio-economic households should be strengthened. In addition, family and community should promote parental interactions through reading and playing with young children. Future studies which directly measure ECD in conjunction with regular monitoring through MICS are recommended.
Obesity and COVID-19 in Children and Adolescents: Reciprocal Detrimental Influence—Systematic Literature Review and Meta-Analysis
Authors: La Fauci Giusy , Montalti Marco , Di Valerio Zeno , Gori Davide , Salomoni Maria Giulia , Salussolia Aurelia , Soldà Giorgia , Guaraldi Federica
Published: June 2022

The dramatic lifestyle changes forced by COVID-19-related lockdown promoted weight gain, with a stronger impact on obese subjects, at higher risk of severe infection. The PubMed database was searched to identify original studies assessing: (1) the extent and risk factors of lockdown-induced weight increase; and (2) the impact of obesity on the risk of hospital admission in children and adolescents. A systematic literature review and meta-analyses were performed. Twenty out of 13,986 identified records were included. A significant weight increase was reported in the majority of subjects, with no apparent gender or age differences. It was induced by a higher consumption of hypercaloric/hyperglycemic/junk food and/or the reduction of physical activity, often associated with an altered sleep–wake cycle. On the other hand, obesity increased the risk of hospitalization (OR = 4.38; 95% C.I. 1.46–13.19; p = 0.009; I2 = 96%) as compared to the normal weight population. COVID-19 and obesity represent epidemic conditions with reciprocal detrimental impact. Urgent public health interventions, targeting the various age and social strata, and involving governmental authorities, health care personnel, teachers and families are warranted to increase awareness and actively promote healthy lifestyles to contrast pediatric obesity and its detrimental consequences at a global level.
Profile of Subclinical Psychopathy in Spanish University Students
Authors: Barbosa-Torres Carlos , Guerrero-Molina Mónica , Moreno-Manso Juan Manuel , García-Baamonde María Elena , Bueso-Izquierdo Natalia
Published: June 2022

Psychopaths are portrayed as deceitful, manipulative, domineering and narcissistic; the result of an irregular and irresponsible interpersonal style that harms both the psychopath him/herself and others. Furthermore, psychopathy is frequently associated with both violent and antisocial conduct. However, subclinical psychopaths are known for manifesting this type of profile without committing crimes. The objective of this study is to examine the differences that exist in subclinical psychopathy concerning gender, the number of intimate relationships and the age of the university student. The number of university students participating was 1289. They were given the Integrated/Subclinical Psychopathy Questionnaire (CUPIS). The results show that, in subclinical psychopathy, men present higher scores than women and younger persons have higher scores than older persons. In addition, the scores in psychopathy are higher for students who have had a larger number of intimate relationships. The contributions of this study allow us to determine the profile associated with subclinical psychopathy.
The Relationship between the Outdoor School Violence Distribution and the Outdoor Campus Environment: An Empirical Study from China
Authors: Ma Xidong , Zhang Zhihao , Li Xiaojiao , Li Yan
Published: June 2022

It is widely believed that outdoor environmental design contributes to outdoor violence prevention. To enhance the effectiveness of environmental design, the intrinsic link between the outdoor school violence distribution (OSVD) and the outdoor campus environment (OCE) should be fully considered. For this purpose, this study investigated boarding school L, located in southern Zhejiang Province of China, through a questionnaire and Spatial Syntax theory. Based on the questionnaire marker method (N = 338, 50.59% female), the OSVD was mapped using the kernel density estimation in ArcGIS, including four types of teacher-student conflict: verbal bullying, physical conflict, and external intrusion. The spatial analysis of the OCE (spatial configuration and spatial visibility) then was generated by the DepthmapX, involving four spatial attributes such as integration, mean depth, connectivity, and visibility connectivity. Statistical analysis results indicated the correlation between the OSVD and both the spatial configuration and spatial visibility of the OCE. For the different violence types, there were differences in the impact relationships, with integration being a significant predictor of teacher-student conflict and physical conflict (p < 0.01) and a general predictor of verbal bullying (p < 0.05), while mean depth was a significant predictor of physical conflict (p < 0.01), but not recommended as a predictor of external intrusion. This study explores and predicts the relationship between the OSVD and the OCE, providing guidance and evidence for school violence prevention environmental design. It is a novel attempt, but still challenging and requires more research to refine.
Exploration of Somatostatin Binding Mechanism to Somatostatin Receptor Subtype 4
Authors: Börzsei Rita , Zsidó Balázs Zoltán , Bálint Mónika , Helyes Zsuzsanna , Pintér Erika , Hetényi Csaba
Published: June 2022

Somatostatin (also named as growth hormone-inhibiting hormone or somatotropin release-inhibiting factor) is a regulatory peptide important for the proper functioning of the endocrine system, local inflammatory reactions, mood and motor coordination, and behavioral responses to stress. Somatostatin exerts its effects via binding to G-protein-coupled somatostatin receptors of which the fourth subtype (SSTR4) is a particularly important receptor mediating analgesic, anti-inflammatory, and anti-depressant effects without endocrine actions. Thus, SSTR4 agonists are promising drug candidates. Although the knowledge of the atomic resolution-binding modes of SST would be essential for drug development, experimental elucidation of the structures of SSTR4 and its complexes is still awaiting. In the present study, structures of the somatostatin–SSTR4 complex were produced using an unbiased, blind docking approach. Beyond the static structures, the binding mechanism of SST was also elucidated in the explicit water molecular dynamics (MD) calculations, and key binding modes (external, intermediate, and internal) were distinguished. The most important residues on both receptor and SST sides were identified. An energetic comparison of SST binding to SSTR4 and 2 offered a residue-level explanation of receptor subtype selectivity. The calculated structures show good agreement with available experimental results and indicate that somatostatin binding is realized via prerequisite binding modes and an induced fit mechanism. The identified binding modes and the corresponding key residues provide useful information for future drug design targeting SSTR4.
State-of-the-Art on Wound Vitality Evaluation: A Systematic Review
Authors: Maiese Aniello , Manetti Alice Chiara , Iacoponi Naomi , Mezzetti Eleonora , Turillazzi Emanuela , Di Paolo Marco , La Russa Raffaele , Frati Paola , Fineschi Vittorio
Published: June 2022

The vitality demonstration refers to determining if an injury has been caused ante- or post-mortem, while wound age means to evaluate how long a subject has survived after the infliction of an injury. Histology alone is not enough to prove the vitality of a lesion. Recently, immunohistochemistry, biochemistry, and molecular biology have been introduced in the field of lesions vitality and age demonstration. The study was conducted according to the preferred reporting items for systematic review (PRISMA) protocol. The search terms were “wound”, “lesion”, “vitality”, “evaluation”, “immunohistochemistry”, “proteins”, “electrolytes”, “mRNAs”, and “miRNAs” in the title, abstract, and keywords. This evaluation left 137 scientific papers. This review aimed to collect all the knowledge on vital wound demonstration and provide a temporal distribution of the methods currently available, in order to determine the age of lesions, thus helping forensic pathologists in finding a way through the tangled jungle of wound vitality evaluation.
Haptoglobin Induces a Specific Proteomic Profile and a Mature-Associated Phenotype on Primary Human Monocyte-Derived Dendritic Cells
Authors: Torres Alfredo , Vivanco Sheilah , Lavín Francisca , Pereda Cristián , Chernobrovkin Alexey , Gleisner Alejandra , Alcota Marcela , Larrondo Milton , López Mercedes N. , Salazar-Onfray Flavio , Zubarev Roman A. , González Fermín E.
Published: June 2022

Damage-associated molecular patterns (DAMPs) play a critical role in dendritic cells (DCs) ability to trigger a specific and efficient adaptive immune response for different physiological and pathological scenarios. We have previously identified constitutive DAMPs (HMGB1 and Calreticulin) as well as new putative inducible DAMPs such as Haptoglobin (HP), from a therapeutically used heat shock-conditioned melanoma cell lysate (called TRIMEL). Remarkably, HP was shown to be the most abundant protein in the proteomic profile of heat shock-conditioned TRIMEL samples. However, its relative contribution to the observed DCs phenotype has not been fully elucidated. Human DCs were generated from monocytes isolated from PBMC of melanoma patients and healthy donors. DC lineage was induced with rhIL-4 and rhGM-CSF. After additional stimulation with HP, the proteome of these HP-stimulated cells was characterized. In addition, DCs were phenotypically characterized by flow cytometry for canonical maturation markers and cytokine production. Finally, in vitro transmigration capacity was assessed using Transwell plates. Our results showed that the stimulation with HP was associated with the presence of exclusive and higher relative abundance of specific immune-; energy production-; lipid biosynthesis-; and DAMPs-related proteins. Importantly, HP stimulation enhanced the expression of specific DC maturation markers and pro-inflammatory and Th1-associated cytokines, and an in vitro transmigration of primary human DCs. Taken together, these data suggest that HP can be considered as a new inducible DAMP with an important role in in vitro DC activation for cancer immunotherapy.
A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery
Authors: Patil Shruti V. , Kasetti Ramesh B. , Millar J. Cameron , Zode Gulab S.
Published: June 2022

Glaucoma is a multifactorial disease leading to irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form and is associated with the elevation of intraocular pressure (IOP). Reduced aqueous humor (AH) outflow due to trabecular meshwork (TM) dysfunction is responsible for IOP elevation in POAG. Extracellular matrix (ECM) accumulation, actin cytoskeletal reorganization, and stiffening of the TM are associated with increased outflow resistance. Transforming growth factor (TGF) β2, a profibrotic cytokine, is known to play an important role in the development of ocular hypertension (OHT) in POAG. An appropriate mouse model is critical in understanding the underlying molecular mechanism of TGFβ2-induced OHT. To achieve this, TM can be targeted with recombinant viral vectors to express a gene of interest. Lentiviruses (LV) are known for their tropism towards TM with stable transgene expression and low immunogenicity. We, therefore, developed a novel mouse model of IOP elevation using LV gene transfer of active human TGFβ2 in the TM. We developed an LV vector-encoding active hTGFβ2C226,228S under the control of a cytomegalovirus (CMV) promoter. Adult C57BL/6J mice were injected intravitreally with LV expressing null or hTGFβ2C226,228S. We observed a significant increase in IOP 3 weeks post-injection compared to control eyes with an average delta change of 3.3 mmHg. IOP stayed elevated up to 7 weeks post-injection, which correlated with a significant drop in the AH outflow facility (40.36%). Increased expression of active TGFβ2 was observed in both AH and anterior segment samples of injected mice. The morphological assessment of the mouse TM region via hematoxylin and eosin (H&E) staining and direct ophthalmoscopy examination revealed no visible signs of inflammation or other ocular abnormalities in the injected eyes. Furthermore, transduction of primary human TM cells with LV_hTGFβ2C226,228S exhibited alterations in actin cytoskeleton structures, including the formation of F-actin stress fibers and crossed-linked actin networks (CLANs), which are signature arrangements of actin cytoskeleton observed in the stiffer fibrotic-like TM. Our study demonstrated a mouse model of sustained IOP elevation via lentiviral gene delivery of active hTGFβ2C226,228S that induces TM dysfunction and outflow resistance.