bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary Patterns Based on Estimated Glomerular Filtration Rate and Kidney Function Decline in the General Population: The Lifelines Cohort Study
Authors: Cai Qingqing , Dekker Louise H. , Bakker Stephan J. L. , de Borst Martin H. , Navis Gerjan J.
Published: April 2020

No specific dietary patterns have been established that are linked with loss of kidney function. We aimed to identify an estimated glomerular filtration rate-based dietary pattern (eGFR-DP) and to evaluate its association with eGFR decline and chronic kidney disease (CKD) incidence in the general population. We included 78,335 participants from the Lifelines cohort in the Northern Netherlands. All participants had an eGFR >60 mL/min/1.73 m2 at baseline and completed a second visit five years later. The eGFR-DP was constructed at baseline using a 110-item food frequency questionnaire by reduced rank regression, stratified by sex. Logistic regression was performed to evaluated the association between the eGFR-DP score and either a ≥20% eGFR decline or incident CKD. Among women, eGFR-DP were characterized by high consumption of egg, cheese, and legumes and low consumption of sweets, white meat, and commercially prepared dishes. In men, eGFR-DP were characterized by high consumption of cheese, bread, milk, fruits, vegetables, and beer and low consumption of white and red meat. A higher eGFR-DP score was associated with a lower risk of a ≥20% eGFR decline (OR 4th vs. 1st quartile, women: 0.79 [95% CI: 0.73–0.87]; men: 0.67 [0.59–0.76]). The association between the eGFR-DP score and CKD incidence was lost upon adjustment for baseline eGFR. Our results provide support for dietary interventions to prevent kidney function decline in the general population.
Maternal Protein Restriction Altered Insulin Resistance and Inflammation-Associated Gene Expression in Adipose Tissue of Young Adult Mouse Offspring in Response to a High-Fat Diet
Authors: Kim Juhae , Choi Alee , Kwon Young Hye
Published: April 2020

Maternal protein restriction is associated with increased risk of insulin resistance and inflammation in adulthood offspring. Here, we investigated whether maternal protein restriction could alter the risk of metabolic syndrome in postweaning high-fat (HF)-diet-challenged offspring, with focus on epididymal adipose tissue gene expression profile. Female ICR mice were fed a control (C) or a low-protein (LP) diet for two weeks before mating and throughout gestation and lactation, and their male offspring were fed an HF diet for 22 weeks (C/HF and LP/HF groups). A subset of offspring of control dams was fed a low-fat control diet (C/C group). In response to postweaning HF diet, serum insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) were increased in control offspring. Maternal LP diet decreased HOMA-IR and adipose tissue inflammation, and increased serum adiponectin level in the HF-diet-challenged offspring. Accordingly, functional analysis revealed that differentially expressed genes (DEGs) enriched in cytokine production were downregulated in the LP/HF group compared to the C/HF group. We also observed the several annotated gene ontology terms associated with innate immunity and phagocytosis in down-regulated DEGs between LP/HF and C/C groups. In conclusion, maternal protein restriction alleviated insulin resistance and inflammation in young offspring mice fed a HF diet but may impair development of immune system in offspring.
Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans
Authors: Duarte Isabella de Araújo Esteves , Milenkovic Dragan , Borges Tatiana Karla dos Santos , Rosa Artur Jordão de Magalhães , Morand Christine , Oliveira Livia de Lacerda de , Costa Ana Maria
Published: April 2020

Background: Passiflora setacea (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans. Methods: Overweight male volunteers (n = 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2). Results: Insulin and homeostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine–cytokine receptor. Conclusion: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases.
Stable Iodine Nutrition During Two Decades of Continuous Universal Salt Iodisation in Sri Lanka
Authors: Jayatissa Renuka , Gorstein Jonathan , Okosieme Onyebuchi E. , Lazarus John H. , Premawardhana Lakdasa D.
Published: April 2020

Universal salt iodisation (USI) was introduced in Sri Lanka in 1995. Since then, four national iodine surveys have assessed the iodine nutrition status of the population. We retrospectively reviewed median urine iodine concentration (mUIC) and goitre prevalence in 16,910 schoolchildren (6–12 years) in all nine provinces of Sri Lanka, the mUIC of pregnant women, drinking-water iodine level, and the percentage of households consuming adequately (15 mg/kg) iodised salt (household salt iodine, HHIS). The mUIC of schoolchildren increased from 145.3 µg/L (interquartile range (IQR) = 84.6–240.4) in 2000 to 232.5 µg/L (IQR = 159.3–315.8) in 2016, but stayed within recommended levels. Some regional variability in mUIC was observed (178.8 and 297.3 µg/L in 2016). There was positive association between mUIC in schoolchildren and water iodine concentration. Goitre prevalence to palpation was a significantly reduced from 18.6% to 2.1% (p < 0.05). In pregnant women, median UIC increased in each trimester (102.3 (61.7–147.1); 217.5 (115.6–313.0); 273.1 (228.9–337.6) µg/L (p = 0.000)). We conclude that the introduction and maintenance of a continuous and consistent USI programme has been a success in Sri Lanka. In order to sustain the programme, it is important to retain monitoring of iodine status while tracking salt-consumption patterns to adjust the recommended iodine content of edible salt.
A Study on the Relationship between Type 2 Diabetes and Taste Function in Patients with Good Glycemic Control
Authors: Pugnaloni Sofia , Alia Sonila , Mancini Margherita , Santoro Vito , Di Paolo Alice , Rabini Rosa Anna , Fiorini Rosamaria , Sabbatinelli Jacopo , Fabri Mara , Mazzanti Laura , Vignini Arianna
Published: April 2020

Type 2 diabetes mellitus (T2DM) has a very high impact on quality of life as it is characterized by disabling complications. There is little evidence about taste alterations in diabetes. Since many individual factors are involved in the onset of diabetes, the purpose of our study is to search a possible link between diabetes and individual taste function. Thirty-two participants with T2DM and 32 volunteers without T2DM (healthy controls) were recruited. Four concentrations of each of the four basic tastes (sweet, sour, salty, bitter), and pure rapeseed oil and water, were applied with cotton pads to the protruded tongue, immediately posterior to its first third, either to the left or right side. The results showed significant differences between groups in the ability to recognize sour, bitter, sweet, and water. Taste scores were lower in subjects with T2DM than in healthy controls, and an age-related decline in taste function was found. The taste function reduction associated with T2DM was not related to gender, disease duration, and glycemic control. In conclusion, it can be hypothesized that a general alteration of taste function can lead patients with type 2 diabetes to search for foods richer in sugars, as in a vicious circle, thus decreasing the likelihood of remission of diabetes mellitus.
Evaluation of the Anti-Tumor Activity of Small Molecules Targeting Eph/Ephrins in APC min/J Mice
Authors: Corrado Miriam , Giorgio Carmine , Barocelli Elisabetta , Marzetti Giuseppe Vittucci , Cantoni Anna Maria , Di Lecce Rosanna , Incerti Matteo , Castelli Riccardo , Lodola Alessio , Tognolini Massimiliano
Published: April 2020

The Eph receptors are the largest receptors tyrosine kinases (RTKs) family in humans and together with ephrin ligands constitute a complex cellular communication system often dysregulated in many tumors. The role of the Eph-ephrin system in colorectal cancer (CRC) has been investigated and different expression of Eph receptors have been associated with tumor development and progression. In light of this evidence, we investigated if a pharmacological approach aimed at inhibiting Eph/ephrin interaction through small molecules could prevent tumor growth in APC min/J mice. The 8-week treatment with the Eph-ephrin antagonist UniPR129 significantly reduced the number of adenomas in the ileum and decreased the diameter of adenomas in the same region. Overall our data suggested as UniPR129 could be able to slow down the tumor development in APC min/J mice. These results further confirm literature data about Eph kinases as a new valuable target in the intestinal cancer and for the first time showed the feasibility of the Eph-ephrin inhibition as a useful pharmacological approach against the intestinal tumorigenesis. In conclusion this work paves the way for further studies with Eph-ephrin inhibitors in order to confirm the Eph antagonism as innovative pharmacological approach with preventive benefit in the intestinal tumor development.
Recombinant Peptide Production Platform Coupled with Site-Specific Albumin Conjugation Enables a Convenient Production of Long-Acting Therapeutic Peptide
Authors: Bak Mijeong , Park Junyong , Min Kiyoon , Cho Jinhwan , Seong Jihyoun , Hahn Young S. , Tae Giyoong , Kwon Inchan
Published: April 2020

The number of therapeutic peptides for human treatment is growing rapidly. However, their development faces two major issues: the poor yield of large peptides from conventional solid-phase synthesis, and the intrinsically short serum half-life of peptides. To address these issues, we investigated a platform for the production of a recombinant therapeutic peptide with an extended serum half-life involving the site-specific conjugation of human serum albumin (HSA). HSA has an exceptionally long serum half-life and can be used to extend the serum half-lives of therapeutic proteins and peptides. We used glucagon-like-peptide 1 (GLP-1) as a model peptide in the present study. A “clickable” non-natural amino acid—p-azido-l-phenylalanine (AzF)—was incorporated into three specific sites (V16, Y19, and F28) of a GLP-1 variant, followed by conjugation with HSA through strain-promoted azide–alkyne cycloaddition. All three HSA-conjugated GLP-1 variants (GLP1_16HSA, GLP1_19HSA, and GLP1_28HSA) exhibited comparable serum half-lives in vivo. However, the three GLP1_HSA variants had different in vitro biological activities and in vivo glucose-lowering effects, demonstrating the importance of site-specific HSA conjugation. The platform described herein could be used to develop other therapeutic peptides with extended serum half-lives.
Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems
Authors: Park Heejun , Ha Eun-Sol , Kim Min-Soo
Published: April 2020

Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the bioavailability (BA) of formulations of poorly water-soluble compounds. However, these formulations have certain limitations, including in vivo drug precipitation, poor in vitro in vivo correlation due to a lack of predictive in vitro tests, issues in handling of liquid formulation, and physico-chemical instability of drug and/or vehicle components. To overcome these limitations, which restrict the potential usage of such systems, the supersaturable SEDDSs (su-SEDDSs) have gained attention based on the fact that the inclusion of precipitation inhibitors (PIs) within SEDDSs helps maintain drug supersaturation after dispersion and digestion in the gastrointestinal tract. This improves the BA of drugs and reduces the variability of exposure. In addition, the formulation of solid su-SEDDSs has helped to overcome disadvantages of liquid or capsule dosage form. This review article discusses, in detail, the current status of su-SEDDSs that overcome the limitations of conventional SEDDSs. It discusses the definition and range of su-SEDDSs, the principle mechanisms underlying precipitation inhibition and enhanced in vivo absorption, drug application cases, biorelevance in vitro digestion models, and the development of liquid su-SEDDSs to solid dosage forms. This review also describes the effects of various physiological factors and the potential interactions between PIs and lipid, lipase or lipid digested products on the in vivo performance of su-SEDDSs. In particular, several considerations relating to the properties of PIs are discussed from various perspectives.
Leaf Water Relations in Lime Trees Grown under Shade Netting and Open-Air
Authors: Mira-García Ana Belén , Conejero Wenceslao , Vera Juan , Ruiz-Sánchez María Carmen
Published: April 2020

Physiological plant water status indicators are useful for managing precision irrigation in regions with limited water resources. The aim of this work was to evaluate the effect of shade netting on the diurnal and seasonal variations of several plant water status indicators in young lime trees (Citrus latifolia Tan., cv. Bearss), grown at the CEBAS-CSIC experimental station in Murcia, Spain. Stem water potential (Ψstem), leaf gas exchange (net photosynthesis (Pn) and stomatal conductance (gs)), and canopy temperature (Tc) were measured on representative days of winter and summer. The Ψstem daily pattern was quite similar in both seasons under both conditions. However, the circadian rhythm of leaf gas exchange was affected by shade conditions, especially in summer, when shaded leaves showed maximum gs values for a longer time, allowing higher net photosynthesis (37%). Canopy temperature behaved similarly in both conditions, nevertheless, lower values were recorded in open-air than in shaded trees in the two seasons. The canopy-to-air temperature difference (Tc − Ta), however, was lower in shaded trees during the daylight hours, indicating the higher degree of leaf cooling that was facilitated by high gs values. The possibility of continuously recording Tc makes it (or the proposed canopy thermal index, CTI) a promising index for precise irrigation scheduling. Shade netting was seen to favour gas exchange, suggesting that it may be considered alternative to open-air for use in semi-arid areas threatened by climate change.
Phenolic Compounds from An Algerian Endemic Species of Hypochaeris laevigata var. hipponensis and Investigation of Antioxidant Activities
Authors: Souilah Nabila , Ullah Zain , Bendif Hamdi , Medjroubi Kamel , Hazmoune Tahar , Hamel Tarek , Öztürk Mehmet , Nieto Gema , Akkal Salah
Published: April 2020

Hypochaeris laevigata var. hipponensis (Asteraceae) is an endemic plant from Algeria. In the current study, we analyzed for the first time its chemical composition, especially phenolic constituents of dichloromethane (DCM), ethyl acetate (EA), and n-butanol (BuOH) fractionsof the aerial parts of Hypochaeris laevigata var. hipponensis by liquid chromatography-mass spectrometry (LC-MS/MS). The number of phenolic compounds detected in DCM, EA, and BuOH fractions were found to be 9, 20, and 15, respectively. More specifically, 12 phenolic acids were detected. Among them, quinic acid, chlorogenic acid, and caffeic acid were the most abundant ones. Meanwhile, only seven flavonoids were detected. Among them, rutin, apigetrin, and isoquercitrin were the major ones. We also determined the total phenolic and flavonoid contents, and fraction EA showed the highest values, followed by BuOH, and DCM fractions. Furthermore, the antioxidant action was dictated by five methods and the tested plant fractions demonstrated a noteworthy antioxidant action.
Dynamics and Rheological Behavior of Chitosan-Grafted-Polyacrylamide in Aqueous Solution upon Heating
Authors: Wang Mengjie , Shangguan Yonggang , Zheng Qiang
Published: April 2020

In this work, the transformation of chitosan-grafted-polyacrylamide (GPAM) aggregates in aqueous solution upon heating was explored by cryo-electron microscope (cryo-TEM) and dynamic light scattering (DLS), and larger aggregates were formed in GPAM aqueous solution upon heating, which were responsible for the thermo-thickening behavior of GPAM aqueous solution during the heating process. The heating initiates a transformation from H-bonding aggregates to a large-sized cluster formed by self-assembled hydrophobic chitosan backbones. The acetic acid (HAc) concentration has a significant effect on the thermo-thickening behavior of GPAM aqueous solution; there is a critical value of the concentration (>0.005 M) for the thermo-thickening of 10 mg/mL GPAM solution. The concentration of HAc will affect the protonation degree of GPAM, and affect the strength of the electrostatic repulsion between GPAM molecular segments, which will have a significant effect on the state of the aggregates in solution. Other factors that have an influence on the thermo-thickening behavior of GPAM aqueous solution upon heating were investigated and discussed in detail, including the heating rate and shear rate.
Simultaneous Enhancement of Photocatalytic Bactericidal Activity and Strength Properties of Acrylonitrile-Butadiene-Styrene Plastic Via a Facile Preparation with Silane/TiO2
Authors: Kiatkittipong Kunlanan , Lim Jun Wei , Cheng Chin Kui , Kiatkittipong Worapon , Assabumrungrat Suttichai
Published: April 2020

This work aims to enhance the photocatalytic antibacterial performance of plastics according to the JIS Z 2801:2010 standard, and to determine their mechanical properties by studying: (i) the influence of calcination on titanium dioxide (TiO2); (ii) modification with different TiO2 concentrations, and; (iii) the effect of silane as a coupling agent. Acrylonitrile-butadiene-styrene plastics (ABS) and Escherichia coli (E. coli) were chosen as the model plastic and bacteria, respectively. The 500 °C calcined TiO2 successfully provided the best photoantibacterial activity, with an approximately 62% decrease of E. coli colony counts following 30 min of exposure. Heat treatment improved the crystallinity of anatase TiO2, resulting in low electron-hole recombination, while effectively adsorbing reactants on the surface. ABS with 500 °C-calcined TiO2 at the concentration of 1 wt % gave rise to the highest performance due to the improved distribution of TiO2. At this point, blending silane coupling agent could further improve the efficacy of photoantibacterial activity up to 75% due to greater interactions with the polymer matrix. Moreover, it could promote a 1.6-fold increase of yield strength via increased adherent bonding between TiO2 and the ABS matrix. Excellent photocatalytic and material stability can be achieved, with constant photocatalytic efficiency remaining for up to five reuse cycles without loss in the yield strength.
Strategies to Functionalize the Anionic Biopolymer Na-Alginate without Restricting Its Polyelectrolyte Properties
Authors: Szabó Luca , Gerber-Lemaire Sandrine , Wandrey Christine
Published: April 2020

The natural anionic polyelectrolyte alginate and its derivatives are of particular interest for pharmaceutical and biomedical applications. Most interesting for such applications are alginate hydrogels, which can be processed into various shapes, self-standing or at surfaces. Increasing efforts are underway to functionalize the alginate macromolecules prior to hydrogel formation in order to overcome the shortcomings of purely ionically cross-linked alginate hydrogels that are hindering the progress of several sophisticated biomedical applications. Particularly promising are derivatives of alginate, which allow simultaneous ionic and covalent cross-linking to improve the physical properties and add biological activity to the hydrogel. This review will report recent progress in alginate modification and functionalization with special focus on synthesis procedures, which completely conserve the ionic functionality of the carboxyl groups along the backbone. Recent advances in analytical techniques and instrumentation supported the goal-directed modification and functionalization.
Biological Effects of Polyrotaxane Surfaces on Cellular Responses of Fibroblast, Preosteoblast and Preadipocyte Cell Lines
Authors: Masuda Hiroki , Arisaka Yoshinori , Sekiya-Aoyama Ruriko , Yoda Tetsuya , Yui Nobuhiko
Published: April 2020

Biointerfaces based on polyrotaxane (PRX), consisting of α-cyclodextrins (α-CDs) threaded on a poly(ethylene glycol) (PEG) chain, are promising functionalized platforms for culturing cells. PRXs are characterized by the molecular mobility of constituent molecules where the threading α-CDs can move and rotate along the PEG chain. Taking advantage of this mobility, we have previously succeeded in demonstrating the regulation of cellular responses, such as cellular adhesion, proliferation, and differentiation. In the present study, we investigated differences in the cellular responses to PRX surfaces versus commercially available tissue culture polystyrene (TCPS) surfaces using fibroblasts, preosteoblasts, and preadipocytes. PRX surfaces were found to more significantly promote cellular proliferation than the TCPS surfaces, regardless of the cell type. To identify the signaling pathways involved in the activation of cellular proliferation, a DNA microarray analysis was performed. PRX surfaces showed a significant increase in the integrin-mediated cell adhesion and focal adhesion pathways. Furthermore, PRX surfaces also promoted osteoblast differentiation more than TCPS. These results suggest that structural features of PRX surfaces act as mechanical cues to dominate cellular proliferation and differentiation.
Ability of Trichoderma hamatum Isolated from Plastics-Polluted Environments to Attack Petroleum-Based, Synthetic Polymer Films
Authors: Malachová Kateřina , Novotný Čeněk , Adamus Grażyna , Lotti Nadia , Rybková Zuzana , Soccio Michelina , Šlosarčíková Pavlína , Verney Vincent , Fava Fabio
Published: April 2020

Microorganisms colonizing plastic waste material collected in composting-, landfill-, and anaerobic digestion plants were isolated to obtain novel strains maximally adapted to the degradation of plastics due to long-term contact with plastic polymers. Twenty-six bacterial strains were isolated and identified by the 16 S rRNA method, and eighteen strains of yeasts and fungi using 18 S rRNA and the internal transcribed spacer ITS sequencing of the 18 S rRNA gene. In selected strains, the ability to degrade linear low-density polyethylene (LLDPE), low-density polyethylene (LDPE), polystyrene (PS), and polyvinyl chloride (PVC) was tested in aerobic liquid-medium cultures. An oxidative, two-step pretreatment of LLDPE and LDPE using γ- or UV-irradiation followed by a high-temperature treatment was carried out, and the pretreated plastics were also included in the degradation experiments. The respective weight losses after biodegradation by Trichoderma hamatum were: virgin and γ/T90-pretreated LLDPE (2.2 ± 1.2 and 3.9 ± 0.5%), virgin and UV/T60-pretreated LDPE (0.5 ± 0.4 and 1.3 ± 0.4%), and virgin PS (0.9 ± 0.4%). The Fourier transform infrared spectroscopy (FTIR) analysis showed that during the treatment of pretreated LLDPE, T. hamatum attacked low molecular weight LLDPE oligomers, reducing the functional groups (carbonyl C = O), which was paralleled by a slight increase of the molar mass of pretreated LLDPE and a decrease of the dispersity index, as demonstrated by gel permeation chromatography (GPC). Thermogravimetric analysis (TGA) highlighted the formation of functional groups on LLDPE due to polymer pretreatment that favored fungal attack at the polymer surface. The results provide insight into microbial consortia that spontaneously colonize the surface of plastics in various environments and their capability to attack plastic polymers.
Protective Effects of Ginger Extract against Glycation and Oxidative Stress-Induced Health Complications: An In Vitro Study
Authors: Anwar Shehwaz , Almatroudi Ahmad , Allemailem Khaled S. , Jacob Joseph Rejo , Khan Amjad Ali , Rahmani Arshad Husain
Published: April 2020

Protein glycation and oxidative stress lead to severe health complications in various diseases including diabetes mellitus. The intake of flavonoid-rich foods has been confirmed previously to have a positive effect on human health. Ginger is an important source of flavonoids and is one of the most widely used traditional medicines in many Asian countries. The aim of this study was to verify the therapeutic potential of methanolic extract from ginger against glycation and other oxidative stress-induced complications using in vitro study. In this study, quantitative estimations of antioxidant components such as total phenolic and flavonoids were determined by UV–visible spectrophotometry. The anti-inflammatory action of the ginger extract was checked by determining its protective action against the denaturation of proteins, anti-proteinase activity and its membrane stabilization effect. The anti-inflammatory action of ginger extract was found to be comparable with reference standard drugs. The antiglycating effect of ginger extract was investigated by placing bovine serum albumin (BSA) with glucose in the presence and absence of ginger extract for two weeks at 37 °C. The incubated samples were analyzed for the number of glycation products, secondary structural changes, aggregation and advanced glycation end products (AGEs) formation by checking browning intensity, determination of aggregation index and Congo red assays. Our findings demonstrated that ginger extract (600 µg/mL) significantly reduced the browning, secondary structural changes, aggregation and AGEs formation. Thus, it can be concluded from these results that ginger extract is a wealthy source of antioxidants and can be used to prevent the glycation and oxidative stress-induced damage of biomolecules in various health complications including inflammation.
An Aristotelian Interpretation of Bojo Jinul and an Enhanced Moral Grounding
Authors: Lee Song-Chong
Published: April 2020

This paper explores the eclecticism of Bojo Jinul (1158–1210 CE), who is arguably the most influential historic figure in establishing and developing the Buddhist monastic institution of Korea. As a great harmonizer of the conflicting Buddhist trends in the late Goryeo period, Jinul not only shaped the foundation of the traditional monastic discipline balanced between theory and practice but also made Korean Buddhist thoughts known to a larger part of East Asia. I revisit the eclecticism of Bojo Jinul on harmonizing the two conflicting understandings of enlightenment represented by Seon (Cha’n) and Gyo (Hwaeom study) schools: the former stressing sudden enlightenment by sitting mediation and oral transmission of dharma and the latter stressing gradual cultivation by the formal training of textual and doctrinal understanding specifically on the Hwaeom Sutra. Utilizing the metaphysics of Aristotle, I confirm the logical validity of his eclecticism and address some of its moral implications.
The Mediating Effect of Coping Strategies on Religious/Spiritual Struggles and Life Satisfaction
Authors: Szcześniak Małgorzata , Kroplewski Zdzisław , Szałachowski Roman
Published: April 2020

A growing number of researchers are testing potential problematic forms of religiousness that denote anxieties regarding sacred matters. However, only a few studies have assessed how religious/spiritual struggle is associated with positive outcomes. Because people’s coping responses to stressors are key determinants of their well-being, we expected that different coping strategies could be potential mediators between religious problems/tensions and life satisfaction. The research was conducted on a group of 744 Roman Catholics. We used the Religious Comfort and Strain Scale, Satisfaction with Life Scale, and Brief Coping Orientation to Problems Experienced (COPE) questionnaire. The outcomes show that religious comfort correlated positively with life satisfaction, while fear/guilt, negative emotions toward God, and negative social interactions surrounding religion correlated negatively with life satisfaction. Our research amplifies the understanding of the religious/spiritual struggles and life satisfaction relationship, mediated by “secular” coping strategies. It confirms that both religious and secular methods of experiencing different strains seem to coexist with multiple other strategies in the context of broadly understood life satisfaction.
Historical, Current, and Future Energy Demand from Global Copper Production and Its Impact on Climate Change
Authors: Rötzer Nadine , Schmidt Mario
Published: April 2020

Copper has always played an important role in human development. Demand for copper is going to rise, which makes its future supply a key issue for society. However, the oft-discussed declining ore grade and, therefore, the assumed enormous increase in energy demand and global warming potential could lead to a supply constraint. To develop suitable strategies to ensure copper availability, it is important to better understand the relationship between energy and ore grade and also its development. Therefore, in this paper we describe the development of the cumulative energy demand of copper production over the last eight decades and give an outlook into the future using a holistic process-based modelling approach. We also discuss how technological progress has thus far been able to offset the decreasing ore grade. However, if geological factors are becoming less favorable, technological improvements such as renewable energies are vital to keep this trend going.
UAV-YOLO: Small Object Detection on Unmanned Aerial Vehicle Perspective
Authors: Liu Mingjie , Wang Xianhao , Zhou Anjian , Fu Xiuyuan , Ma Yiwei , Piao Changhao
Published: April 2020

Object detection, as a fundamental task in computer vision, has been developed enormously, but is still challenging work, especially for Unmanned Aerial Vehicle (UAV) perspective due to small scale of the target. In this study, the authors develop a special detection method for small objects in UAV perspective. Based on YOLOv3, the Resblock in darknet is first optimized by concatenating two ResNet units that have the same width and height. Then, the entire darknet structure is improved by increasing convolution operation at an early layer to enrich spatial information. Both these two optimizations can enlarge the receptive filed. Furthermore, UAV-viewed dataset is collected to UAV perspective or small object detection. An optimized training method is also proposed based on collected UAV-viewed dataset. The experimental results on public dataset and our collected UAV-viewed dataset show distinct performance improvement on small object detection with keeping the same level performance on normal dataset, which means our proposed method adapts to different kinds of conditions.
Semantic Segmentation of Natural Materials on a Point Cloud Using Spatial and Multispectral Features
Authors: Jurado J. M. , Cárdenas J. L. , Ogayar C. J. , Ortega L. , Feito F. R.
Published: April 2020

The characterization of natural spaces by the precise observation of their material properties is highly demanded in remote sensing and computer vision. The production of novel sensors enables the collection of heterogeneous data to get a comprehensive knowledge of the living and non-living entities in the ecosystem. The high resolution of consumer-grade RGB cameras is frequently used for the geometric reconstruction of many types of environments. Nevertheless, the understanding of natural spaces is still challenging. The automatic segmentation of homogeneous materials in nature is a complex task because there are many overlapping structures and an indirect illumination, so the object recognition is difficult. In this paper, we propose a method based on fusing spatial and multispectral characteristics for the unsupervised classification of natural materials in a point cloud. A high-resolution camera and a multispectral sensor are mounted on a custom camera rig in order to simultaneously capture RGB and multispectral images. Our method is tested in a controlled scenario, where different natural objects coexist. Initially, the input RGB images are processed to generate a point cloud by applying the structure-from-motion (SfM) algorithm. Then, the multispectral images are mapped on the three-dimensional model to characterize the geometry with the reflectance captured from four narrow bands (green, red, red-edge and near-infrared). The reflectance, the visible colour and the spatial component are combined to extract key differences among all existing materials. For this purpose, a hierarchical cluster analysis is applied to pool the point cloud and identify the feature pattern for every material. As a result, the tree trunk, the leaves, different species of low plants, the ground and rocks can be clearly recognized in the scene. These results demonstrate the feasibility to perform a semantic segmentation by considering multispectral and spatial features with an unknown number of clusters to be detected on the point cloud. Moreover, our solution is compared to other method based on supervised learning in order to test the improvement of the proposed approach.
Using a Neural Network Analysis to Assess Stressors in the Farming Community
Authors: Beseler Cheryl , Stallones Lorann
Published: April 2020

In the 1980s and 1990s, with decreasing numbers of full-time farmers and adverse economic conditions, chronic stress was common in farmers, and remains so today. A neural network was implemented to conduct an in-depth analysis of stress risk factors. Two Colorado farm samples (1992–1997) were combined (n = 1501) and divided into training and test samples. The outcome, stress, was measured using seven stress-related items from the Center for Epidemiologic Studies-Depression Scale. The initial model contained 32 predictors. Mean squared error and model fit parameters were used to identify the best fitting model in the training data. Upon testing for reproducibility, the test data mirrored the training data results with 20 predictors. The results highlight the importance of health, debt, and pesticide-related illness in increasing the risk of stress. Farmers whose primary occupation was farming had lower stress levels than those who worked off the farm. Neural networks reflect how the brain processes signals from its environment and algorithms allow the neurons “to learn”. This approach handled correlated data and gave greater insight into stress than previous approaches. It revealed how important providing health care access and reducing farm injuries are to reducing farm stress.
Government Background Customers and Private Enterprise Innovation from the Perspective of Supply Chain Risk Transmission
Authors: Chen Zhanguang , Wang Qiaowan , Dou Chao , Liang Tian
Published: April 2020

Private enterprises are major contributors to China’s market economy. In order to ensure the sustainability of economic development, China pays more attention to the role of science and technology in promoting the sustainability of the private economy. Based on a sample of all A-share listed companies in the Chinese capital market, we distinguished between government and non-government purchase order data, and examined the impact of large government background customers on private enterprise R&D innovation from the perspective of supply chain risk transmission. Due to the implementation of China’s new accounting standards and the delay in the public update of government procurement data, we selected samples from 2007‒2015. The research results show that the government background customers can significantly increase the R&D investment of private enterprises, and this relationship is more significant in the sample of mid-level government background customers and private enterprises in poor areas; further analysis found that government background purchase orders can promote innovation investment by mitigating the risks facing a company. From a practical point of view, the research findings of this paper are helpful for understanding the impact of customer structure on the innovation activities of enterprises in a market economy environment.
The Role of Collaborative Healthcare in Improving Social Sustainability: A Conceptual Framework
Authors: Maghsoudi Tahereh , Cascón-Pereira Rosalía , Beatriz Hernández Lara Ana
Published: April 2020

Healthcare systems around the world face both increasing demands and inequality in service distribution. The current trend is for collaboration among healthcare actors, named as collaborative healthcare, in order to address challenges such as these to improve the social sustainability of the system. That is to provide accessible and equitable healthcare services to meet people’s health and well-being needs. Based on an integrative literature review, this study aims at crafting a conceptual framework to explore how collaborative healthcare networks contribute to social sustainability and the specific actors involved in these collaborations. It identifies relationships between different collaborative healthcare networks and social sustainability. Interprofessional networks have been the most studied in relation to social sustainability. Communication and sharing information or knowledge have been identified as used collaborative healthcare practices. This study contributes theoretically by considering a new model of the healthcare organization in which collaborative networks play a central role in improving social sustainability. In terms of practical implications, the study provides managers and policy makers with investment insights on a range of collaborative networks and practices.
Assessing Neighborhood Satisfaction and Social Capital in a Multi-Cultural Setting of an Abu Dhabi Neighborhood
Authors: Al-Ali Anfal , Maghelal Praveen , Alawadi Khaled
Published: April 2020

Behavioral research studies propose that urban open spaces contribute to enhance sociability in urban areas. The urban areas in the city of Abu Dhabi are less appealing to attract vibrant activity and social life. This study investigates the role of the built environment in the enhancement of neighborhood satisfaction and social capital in a residential neighborhood of Abu Dhabi. A total of 145 residents were surveyed for their perception, attitude, and behavior. Regression analyses to predict the role of the built environment of the open space, as well as the ethnicity of respondents, on measures of neighborhood satisfaction and social capital were performed. Spatial data and audit tools were used to assess the lack of suitable built-environment in the study area. Results indicate that improvements to the built environment can improve both the social capital and neighborhood satisfaction of the urban residents of Abu Dhabi. Implications of this study include recommendations to enhance the experience of urban spaces in arid regions like Abu Dhabi. Recommendations include adding landscape elements, providing a comfortable walking environment, adding attractive locations and destinations, and a clean and safe environment with attractive buildings or homes.
Mitigation of Methane, NMVOCs and Odor Emissions in Active and Passive Biofiltration Systems at Municipal Solid Waste Landfills
Authors: Pecorini Isabella , Rossi Elena , Iannelli Renato
Published: April 2020

Biofiltration systems are emerging technological solutions for the removal of methane and odors from landfill gas when flaring is no longer feasible. This work analyzed and compared two full-scale biofiltration systems: biofilter and biowindows. The emission mitigation of methane, non-methane volatile organic compounds (NMVOCs) and odors during a two-year management and monitoring period was studied. In addition to diluted methane, more than 50 NMVOCs have been detected in the inlet raw landfill gas and the sulfur compounds resulted in the highest odor activity value. Both systems, biofilter and biowindows, were effective for the oxidation of methane (58.1% and 88.05%, respectively), for the mitigation of NMVOCs (higher than 80%) and odor reduction (99.84% and 93.82% respectively). As for the biofilter monitoring, it was possible to define the oxidation efficiency trend and in fact to guarantee that for an oxidation efficiency of 80%, the methane load must be less than 6.5 g CH4/m2h with an oxidation rate of 5.2 g CH4/m2h.
Prioritizing Safety or Traffic Flow? Qualitative Study on Highly Automated Vehicles’ Potential to Prevent Pedestrian Crashes with Two Different Ambitions
Authors: Utriainen Roni , Pöllänen Markus
Published: April 2020

Interaction between drivers and pedestrians enables pedestrians to cross the street without conflicts. When highly automated vehicles (HAVs) become prevalent, interaction will change. Although HAVs manage to identify pedestrians, they may not be able to assess pedestrians’ intentions. This study discusses two different ambitions: Prioritizing pedestrian safety and prioritizing efficient traffic flow; and how these two affect the possibilities to avoid fatal crashes between pedestrians and passenger cars. HAVs’ hypothetical possibilities to avoid different crash scenarios are evaluated based on 40 in-depth investigated fatal pedestrian crashes, which occurred with manually-driven cars in Finland in 2014–2016. When HAVs prioritize pedestrian safety, they decrease speed near pedestrians as a precaution which affects traffic flow due to frequent decelerations. When HAVs prioritize efficient traffic flow, they only decelerate, when pedestrians are in a collision course. The study shows that neither of these approaches can be applied in all traffic environments, and all of the studied crashes would not likely be avoidable with HAVs even when prioritizing pedestrian safety. The high expectations of HAVs’ safety benefits may not be realized, and in addition to safety and traffic flow, there are many other objectives in traffic which need to be considered.
Social Life-Cycle Assessment of Household Waste Management System in Kabul City
Authors: Azimi Ahmad Nadim , Dente Sébastien M. R. , Hashimoto Seiji
Published: April 2020

The present study constitutes the first social life cycle assessment (SLCA) study in Afghanistan and aims at assessing the social performance of the waste management system (WMS) of Kabul city. The system boundary considered includes households generating the waste, the sanitation department of Kabul city, scavengers, recycling shops, the recycling factory, and the local community living in its vicinity. Compared to previous SLCA studies that consider one stakeholder per organization, we distinguished between the manager and the worker level for each organization. In total, eight stakeholders, 90 inventory indicators, and 20 impact subcategories were investigated. Results show three main social issues: the overwork of scavengers, recycling shop owners and recycling factories’ workers and managers, the absence of communication and implication of the local community, and the poor cleanliness of the surroundings of the recycling factory and collection points. At the sanitation department, managers were found facing more psychological stress and overwork than workers, demonstrating the current isolation of the department inside Kabul’s local government. It seems nonetheless possible to improve Kabul’s WMS by redesigning the location of garbage bins and conducting communication campaigns towards consumers and the local community. That would help to minimize the nuisances associated with the handling of waste and to integrate better waste management activities into the socio-economy of Kabul city.
Design Concept for a Greened Timber Truss Bridge in City Area
Authors: Kromoser Benjamin , Ritt Martin , Spitzer Alexandra , Stangl Rosemarie , Idam Friedrich
Published: April 2020

Properly designed wooden truss bridges are environmentally compatible construction systems. The sharp decline in the erection of such structures in the past decades can be led back to the great effort needed for design and production. Digital parametric design and automated prefabrication approaches allow for a substantial improvement of the efficiency of design and manufacturing processes. Thus, if combined with a constructive wood protection following traditional building techniques, highly efficient sustainable structures are the result. The present paper describes the conceptual design for a wooden truss bridge drawn up for the overpass of a two-lane street crossing the university campus of one of Vienna’s main universities. The concept includes the greening of the structure as a shading design element. After an introduction, two Austrian traditional wooden bridges representing a good and a bad example for constructive wood protection are presented, and a state of the art of the production of timber trusses and greening building structures is given as well. The third part consists of the explanation of the boundary conditions for the project. Subsequently, in the fourth part, the conceptual design, including the design concept, the digital parametric design, the optimization, and the automated prefabrication concept, as well as the potential greening concept are discussed, followed by a summary and outlook on future research.
Towards the IMO’s GHG Goals: A Critical Overview of the Perspectives and Challenges of the Main Options for Decarbonizing International Shipping
Authors: Serra Patrizia , Fancello Gianfranco
Published: April 2020

The Initial Strategy on reduction of greenhouse gas (GHG) emissions from ships adopted by the International Maritime Organization (IMO) in 2018 commits the IMO to reduce total GHG emissions of shipping by at least 50% by 2050. Though the direction of the Strategy is clear, the path to implementation remains uncertain. The ambitious IMO’s target calls for widespread uptake of lower and zero-carbon fuels, in addition to other energy efficiency measures, including operational and market ones. Using a triangulated research approach, this paper provides a critical overview of the main measures and initiatives the shipping industry can adopt to try to cope with the new IMO’s requirements. The pros and cons of the most popular emission reduction options are investigated along with the main challenges and barriers to implementation and the potential facilitators that could foster a wider application. The framework that is outlined is complex and not without controversy. Research can play a key role as a facilitator of shipping’s decarbonization by providing its contribution to overcoming the existing controversies on various decarbonization options and by developing a wealth of knowledge that can encourage the implementation of low-carbon initiatives.