bluuebunny/crossref_metadata_2025 huggingface dataset:
Centering the Right to Health of Childbearing People in the US During the COVID-19 Pandemic
Authors: Tomori Cecília , Penta Bhavana , Richman Rebecca
Published: June 2022

Childbearing people in the US have experienced the double burden of increased risks from infection and significant disruptions to access and quality of essential health care services during the COVID pandemic. A single person could face multiple impacts across the course of their reproductive trajectory. We highlight how failure to prioritize this population in the COVID-19 policy response have led to profound disruptions from contraception services to vaccination access, which violate foundational principles of public health, human rights and perpetuate inequities. These disruptions continued through the omicron surge, during which many health systems became overwhelmed and re-imposed earlier restrictions. We argue that an integrated pandemic response that prioritizes the healthcare needs and rights of childbearing people must be implemented to avoid deepening inequities in this and future pandemics.
Multimorbidity Among Urban Poor in India: Findings From LASI, Wave-1
Authors: Sinha Abhinav , Kerketta Sushmita , Ghosal Shishirendu , Kanungo Srikanta , Pati Sanghamitra
Published: June 2022

Background

Multimorbidity has become a norm in low-and middle-income countries such as India requiring notable health system improvements to combat. Urban population is a heterogeneous group where poor are at a risk of facing inequity in accessing healthcare services which can jeopardize our efforts to attain universal health coverage (UHC). We aimed to estimate the prevalence, assess correlates and patterns of multimorbidity among urban poor. Further, we assessed the outcomes of multimorbidity such as healthcare utilization, expenditure and self-rated health.

Methods

Longitudinal Aging Study in India (LASI), wave-1 is a nationally representative survey conducted amongst participants aged ≥45 years in 2017–18. We included 9,327 participants residing in urban areas, categorized as poor based on monthly per capita expenditure. Descriptive statistics computed prevalence with 95% uncertainty interval. Multivariable logistic regression was executed to assess the association between multimorbidity and various correlates, expressed as adjusted odds ratio. An ordinal regression model was run between self-rated health and number of chronic conditions.

Results

The prevalence of multimorbidity was 45.26% among the urban poor. Hypertension and oral morbidities were the most commonly observed dyad. Respondents who were poorer [AOR: 1.27 (1.06–1.51)] had higher chances of having multimorbidity than the poorest. Respondents with a health insurance [AOR: 1.40 (1.14–1.70)] had a higher risk of having multimorbidity. In-patient admission was significantly higher among participants having multimorbidity. Out of pocket expenditure increased while self-rated health deteriorated with each additional morbid condition.

Conclusion

Multimorbidity is found to be increasingly prevalent among urban poor and individuals having health insurance which demonstrates the need to expand healthcare insurance schemes such as Ayushman Bharat for urban poor to achieve UHC.
The Intestine as a Lifespan- and Proteostasis-Promoting Signaling Tissue
Authors: Hodge Francesca , Bajuszova Viktoria , van Oosten-Hawle Patricija
Published: June 2022

In multicellular organisms such as Caenorhabditis elegans, cellular stress stimuli and responses are communicated between tissues to promote organismal health- and lifespan. The nervous system is the predominant regulator of cell nonautonomous proteostasis that orchestrates systemic stress responses to integrate both internal and external stimuli. This review highlights the role of the intestine in mediating cell nonautonomous stress responses and explores recent findings that suggest a central role for the intestine to regulate organismal proteostasis. As a tissue that receives and further transduces signals from the nervous system in response to dietary restriction, heat- and oxidative stress, and hypoxia, we explore evidence suggesting the intestine is a key regulatory organ itself. From the perspective of naturally occurring stressors such as dietary restriction and pathogen infection we highlight how the intestine can function as a key regulator of organismal proteostasis by integrating insulin/IGF-like signaling, miRNA-, neuropeptide- and metabolic signaling to alter distal tissue functions in promoting survival, health- and lifespan.
Structure and Pattern Formation in Biological Liquid Crystals: Insights From Theory and Simulation of Self-Assembly and Self-Organization
Authors: Wang Ziheng , Servio Phillip , Rey Alejandro D.
Published: June 2022

This review presents theory and simulation of liquid crystal phase ordering in biological fibrous materials, solutions, and composites in the presence of elastic fields, second phase inclusions, and transport phenomena, including complex shear-extensional flow and mass transfer. Liquid crystal self-assembly through phase ordering on elastic deformable membranes is first applied to characterize the mechanisms that control the structures in plant cell walls, highlighting how curvophobic and curvophilic effects introduce new structuring fields beyond hard-core repulsion. Then chiral nematic self-assembly is simulated in a mesophase containing fibrillar colloidal inclusions (liquid crystal-fibre composites) to demonstrate how the inclusion positional order generates defects and disclinations as shown in the plant cell wall. Coupling phase ordering to tuned transport phenomena is shown how and why it leads to self-organization such as paranematic states of dilute acidic aqueous collagen solutions. Further directed dehydration of well-organized paranematic collagen leads to defect free cholesteric films only when directed dehydration is synchronized with chirality formation. In addition, the ubiquitous surface nanowrinkling of cholesterics is captured with surface anchoring. In these four representative systems, the new mechanisms that enhance the well-known exclude volume interactions are identified quantified and validated with experimental data. Future directions to create new advanced multifunctional materials based on principles of self-assembly and self-organization are identified by leveraging the new couplings between material structure, geometry, and transport phenomena.
Exposure to a Virtual Environment Induces Biological and Microbiota Changes in Onset-of-Lay Hens
Authors: Redweik Graham A. J. , Millman Suzanne T. , Parsons Rebecca L. , Hurtado Terminel Alejandro N. , Radkowski Rafael , Daniels Karrie , Lyte Mark , Oliver James , Mellata Melha
Published: June 2022

Increasing demand for cage-free eggs arises from goals to provide hens with better welfare, particularly in terms of natural behavior. However, most laying hens are kept in conventional cages, and cage-free systems can present challenges, such as injuries, floor eggs, and bacterial infections. We proposed using virtual reality (VR) as a feasible means for combining the positive attributes of natural environments while mitigating health risks. To our knowledge, no animal study has provided evidence that VR can trigger biological changes to improve animal health and well-being nor whether VR can affect the gut microbiota. In this study, we used VR technology to simulate a natural environment in laying hen housing. Early-lay White Leghorn hens were placed in pens with (VR) or without (CON) video projections displaying free-range chickens interacting with indoor and outdoor environmental features over 5 days. Using in vitro blood bactericidal assays, VR hens exhibited higher resistance against avian pathogenic Escherichia coli versus CON (p < 0.05), which was positively associated with corticosterone levels (p < 0.01). Analyzing intestinal neurochemicals via ultra-high pressure liquid chromatography, salsolinol was the only neurochemical metabolite affected by VR, being greater in CON ileal content (p < 0.0001), in VR ileal mucus (p < 0.01), and in VR ceca tissue (p < 0.05). Using 16S rRNA sequencing and QIIME2 analyses, no differences in alpha nor beta diversity were determined between groups. Although several genera (Megamonas, Ruminococcus, Slackia) were reduced in VR hens versus CON, Mucispirillum schaedleri (member of Deferribacteres Phylum) was the only taxon increased in VR hens, being elevated in ileal mucus (p < 0.05). Lastly, using the QIIME2 plugin mmvec to map microbe-metabolite co-occurrences, we identified several positive relationships between bacterial phyla and neurochemical metabolites, notably finding dopamine and salsolinol levels were related to Deferribacteres and Tenericutes levels. In conclusion, we found that several biological parameters were influenced by VR treatment in hens, suggesting that VR can be used to improve host resistance to pathogens and gut health in poultry.
Exogenous Melatonin Directly and Indirectly Influences Sheep Oocytes
Authors: Chen Yang , Shan Xuesong , Jiang Huaizhi , Guo Zhenhua
Published: June 2022

Understanding whether and how melatonin (MT) may impact sheep oocyte development competence is central to our ability to predict how sheep oocytes will respond to artificially regulated estrus. Implanting MT can make sheep enter estrus during the non-breeding season. One study found that the blastocyst rate increased under MT treatment, while another found that the blastocyst rate decreased. Therefore, we conducted a meta-analysis of MT directly and indirectly influencing sheep oocytes. A total of 433 articles were collected from which 20 articles and 34 treatments were finally selected. A method for estimating the default value was established for the litter size analysis. We found that exogenous MT add into in vitro maturation medium was positively related to the blastocyst rate in the lab. However, subcutaneous implanting MT did not affect the in vivo ovulation rate, fertilization rate, blastocyst rate, or pregnancy rate at farm. MT did not affect the in vitro cleavage rate. However, MT improved the in vivo cleavage rate. We hypothesized that implanted MT could increase the concentration of MT in oviduct fluid in vivo, and also that in vitro MT could increase the early cleavage rate of sheep zygotes without affecting the total cleavage rate. In the analysis of oocyte apoptosis caused by injury, the results suggested that pyroptosis would be more suitable for further research. MT produces responses in all body organs, and thus implanting of MT during non-breeding seasons should consider the effect on animal welfare.
Case Report: Successful Management and Long-Term Follow-Up of Bilateral Ureteral Ligation in a Dog Secondary to Cryptorchid Castration Utilizing Bilateral Ureteral Stents and a Neoureterocystostomy Procedure
Authors: Walton Rebecca , Mickelson Megan , Palerme Jean-Sebastien , Blong April , 't Hoen Meredith
Published: June 2022

Objective

To report the successful management of the bilateral ureteral obstruction secondary to ureteral ligation during unilateral cryptorchid surgery in a dog with the utilization of bilateral ureteral stent placement and a neoureterocystostomy procedure.

A 7-month-old male-castrated Weimaraner weighing 30 kg was presented to a university teaching hospital for evaluation of a 4-day history of lethargy, vomiting, and stranguria following exploratory laparotomy for a left-sided unilateral cryptorchid castration. Based on the concurrent presence of severe azotemia and ultrasonographic findings of bilateral hydronephrosis and hydroureter, the dog was diagnosed with the suspected bilateral ureteral obstruction. The dog underwent a laparotomy which revealed bilateral ureteral ligation which was corrected with a left-sided neoureterocystostomy and right-sided retrograde ureteral stent placement. Subsequent placement of a left-sided ureteral stent due to complications with the neoureterocystostomy site was performed later. Ultimately, both ureteral stents were able to be removed a few months later. The dog was clinically doing well with a baseline creatinine of 1.5 mg/dl (132.6 μmol/L) 532 days following initial bilateral ureteral ligation.

New or Unique Information Provided

This case report describes the successful long-term management of iatrogenic bilateral ureteral obstructions in a male dog using a combination of bilateral ureteral stents and neoureterocystostomy.
Impacts of Heat Stress on Rabbit Immune Function, Endocrine, Blood Biochemical Changes, Antioxidant Capacity and Production Performance, and the Potential Mitigation Strategies of Nutritional Intervention
Authors: Liang Zi-Long , Chen Fan , Park Sungkwon , Balasubramanian Balamuralikrishnan , Liu Wen-Chao
Published: June 2022

Heat stress has become a widespread concern in the world, which is one of the major environmental stressors and causes substantial economic loss in the rabbit industry. Heat stress leads to multiple damages to the health of rabbits, such as organ damage, oxidative stress, disordered endocrine regulation, suppressed immune function and reproductive disorders, ultimately, induces the decreased production performance and increased mortality. Nutritional approaches, including feeding strategies, adjusting feed formula, and supplementing vitamins, minerals, electrolytes, Chinese herbal medicines, and functional active substances to the feed, were reported to mitigate the detrimental effects of heat stress in rabbits. Therefore, elucidating the damage of heat stress to rabbits; proper management and nutritional approaches should be considered to solve the heat stress issue in rabbits. This review highlights the scientific evidence regarding the effects of heat stress on rabbit's immune function, endocrine, blood biochemical changes, antioxidant capacity and production performance, and the potential mitigation strategies of nutritional intervention to alleviate heat stress in rabbits; which could contribute to develop nutritional strategies in relieving heat stress of rabbits.
Chronic Disease Management for People With Hypertension
Authors: Lee Woo-Ri , Yoo Ki-Bong , Jeong Jiyun , Koo Jun Hyuk
Published: June 2022

Objectives: To assess the effectiveness of continuity of care policies by identifying the impact of a chronic disease management program on the continuity of care in patients with hypertension in South Korea.

Methods: The propensity score matching method was used to control selection bias, and the difference-in-differences method was used to compare the impact on the treatment and control groups according to the policy intervention.

Results: The continuity of care index of hypertensive patients using the difference-in-differences analysis outcome of the chronic disease management program was higher than that of the non-participating hypertensive patients.

Conclusion: Continuous treatment is vital for chronic diseases such as hypertension. However, the proportion of those participating in the intervention was low. Encouraging more hypertensive patients to participate in policy intervention through continuous research and expanding the policy to appropriately reflect the increasing number of chronic diseases is necessary.
Constructing the Neighborhood Structure of VNS Based on Binomial Distribution for Solving QUBO Problems
Authors: Pambudi Dhidhi , Kawamura Masaki
Published: June 2022

The quadratic unconstrained binary optimization (QUBO) problem is categorized as an NP-hard combinatorial optimization problem. The variable neighborhood search (VNS) algorithm is one of the leading algorithms used to solve QUBO problems. As neighborhood structure change is the central concept in the VNS algorithm, the design of the neighborhood structure is crucial. This paper presents a modified VNS algorithm called “B-VNS”, which can be used to solve QUBO problems. A binomial trial was used to construct the neighborhood structure, and this was used with the aim of reducing computation time. The B-VNS and VNS algorithms were tested on standard QUBO problems from Glover and Beasley, on standard max-cut problems from Helmberg–Rendl, and on those proposed by Burer, Monteiro, and Zhang. Finally, Mann–Whitney tests were conducted using α=0.05, to statistically compare the performance of the two algorithms. It was shown that the B-VNS and VNS algorithms are able to provide good solutions, but the B-VNS algorithm runs substantially faster. Furthermore, the B-VNS algorithm performed the best in all of the max-cut problems, regardless of problem size, and it performed the best in QUBO problems, with sizes less than 500. The results suggest that the use of binomial distribution, to construct the neighborhood structure, has the potential for further development.
Experimental and Numerical Study on Incident Shock Wave/Boundary Layer Interaction Control
Authors: Zhang Chuanbiao , Luo Yanhao , Liang Hua , Guo Shanguang , Yang Hesen
Published: June 2022

This study was designed to explore the control effect of pulsed arc discharge plasma actuation on the incident shock wave/boundary layer interaction (ISWBLI). Research was conducted on an ISWBLI flow field with 10 kHz single-channel pulsed arc discharge plasma actuation and pulsed arc discharge plasma actuation array applied at Mach 2.0 experimentally and numerically. In the investigation, high-speed schlieren flow field visualization technology was adopted, focusing on the change in shock wave intensity caused by plasma actuation. Combined with the detached eddy simulation (DES) method, the numerical simulation focused on the regulating effect of plasma actuation on the separation zone. The key research results showed that, in terms of the spatial flow field, the simulation results were consistent with the experimental results. The single-channel actuation could only just achieve the control effect on the ISWBLI, while array actuation effectively weakened the shock wave intensity. Furthermore, the ISWBLI separation zone in the base flow field was crescent shaped. Its length at the middle of the flat plate was longer than that at the two sides. It was identified that, after applying single-channel actuation, the start of separation slightly moved forward. Similarly, after the application of array actuation, the start point of separation at the middle section in a spanwise direction moved forward by about 19 mm. The length of the separation zone increased by 30 mm but reduced at the two sides. Its influence, spanwise, was also significantly diminished.
Milk Thistle (Silybum marianum), Marine Algae (Spirulina platensis) and Toxin Binder Powders in the Diets of Broiler Chickens Exposed to Aflatoxin-B1: Growth Performance, Humoral Immune Response and Cecal Microbiota
Authors: Feshanghchi Mostafa , Baghban-Kanani Payam , Kashefi-Motlagh Bahman , Adib Fariba , Azimi-Youvalari Saba , Hosseintabar-Ghasemabad Babak , Slozhenkina Marina , Gorlov Ivan , Zangeronimo Márcio G. , Swelum Ayman A. , Seidavi Alireza , Khan Rifat U. , Ragni Marco , Laudadio Vito , Tufarelli Vincenzo
Published: June 2022

This research was performed to investigate the effects of milk thistle (MT), toxin binder (TB) and marine algae (Spirulina platensis; SP) on the performance, blood indices, humoral immunity and cecal microbiota of broiler chickens exposed to aflatoxin-B1 (AFB1). A total of 300 one-day-old male chicks were equally divided into five treatments, with six replicates with 10 birds per treatment. Dietary treatments included: (T1) a control diet (without any feed additive or AFB1); (T2) control diet + 0.6 mg AFB1/kg; (T3) T2 + 10 g/kg MT; (T4) T2 + 1 g/kg TB; and (T5) T2 + 10 g/kg SP. BWG and FI were found to be considerably reduced in broilers given AFB1-contaminated diets (p < 0.05). The FCR was negatively influenced in birds fed AFB1-contaminated diets (p < 0.05). MT, TB, and SP powders also reduced the deleterious effects of AFB1 on the growth of chickens (p < 0.05). In comparison with the control birds and the other treatments, broilers given AFB1-contaminated diets had a higher relative weight of abdominal fat (p < 0.05). The feeding of AFB1 resulted in a substantial rise in AST and ALT activity (p < 0.05). MT, TB, and SP powders significantly decreased blood AST and ALT activity in broilers (p < 0.05). The AFB1 and MT groups had the lowest skin thickness (p < 0.05) twenty-four hours after injection. The phytohemagglutinin injection results showed that the TB and SP were more efficient than the other additives in removing toxins from the feed sources (p < 0.05). The antibody titer against sheep red blood cells (SRBCs) was lower in the AFB1 group compared to the control group at 28 days of age (p < 0.05). When comparing AFB1-fed chicks to the control treatment, there was a significant (p < 0.05) concentration of cecal Coliform bacteria. When MT, TB, and SP powders were added to AFB1-contaminated diet, cecal Coliforms were decreased (p < 0.05). When fed AFB1-contaminated diets, it can be concluded that MT, TB, and SP are suitable for supporting growth performance, immunological function, and the serum biochemical parameters of broiler chickens.
Optimization Design Based on I-GA and Simulation Test Verification of 5-Stage Hydraulic Mechanical Continuously Variable Transmission Used for Tractor
Authors: Cheng Zhun , Chen Yuting , Li Wenjie , Zhou Pengfei , Liu Junhao , Li Li , Chang Wenjuan , Qian Yu
Published: June 2022

To improve the characteristics of a tractor power transmission system, make the transmission system not only meet the geometric principle but also meet the working speed requirements of the tractor, realize the continuous adjustment of the speed ratio, and solve the power interruption caused by the change of speed ratio. This paper not only proposes a new type of five-stage hydraulic mechanical continuously variable transmission (HMCVT), but also proposes a geometric design method based on I-GA. In this paper, the intersection position of each working section is introduced in the optimization design process, and six wet clutches, one brake and two planetary rows are used to achieve a flexible geometric design. The results show that the HMCVT proposed in this paper can effectively match the required speed of the tractor. After optimization, the transmission ratio characteristics are consistent with the target characteristics (the average error is about 3.27% and the common ratio is about 1.81); the simulation results based on Simulation X are highly consistent with the theoretical design values (the MAPE of 36 simulation experiments is about 0.72%); and the maximum speed of the tractor is 41.62 km/h. The proposed HMCVT design scheme and optimization design method provide a direct basis for the research and development of the composite power transmission system of tractors or other vehicles and agricultural machinery.
Unintentional Recovery of Parasitic Diversity Following Restoration of Red Deer (Cervus elaphus) in North-Western Italy
Authors: Moroni Barbara , Begovoeva Mattia , Rossi Luca , Angelone Samer , Robetto Serena , Visconti Luca , Regis Anna , Viganò Roberto , Preacco Nicole , Zoppi Simona , Rambozzi Luisa , Meneguz Pier Giuseppe
Published: June 2022

Red deer (Cervus elaphus) populations in north-western Italy have been remodeled in recent decades. Multiple translocations and the spontaneous migration from Switzerland and France resulted in the successful redistribution of the red deer after human-driven extirpation during the 18th century. The scarcely diverse parasitic community harbored by these cervids has been enriched with two species-specific taxa, Onchocerca jakutensis and Phayigomyia picta, suggesting that the recovery of parasitic biodiversity could be included amongst future conservation goals of this intensively managed game. Nodular onchocercosis was reported in three red deer populations since 2011, while nasal bots were reported since 2018. Hypoderma spp. larvae were identified for the first time in 1989, then a second record was made in 2014 in the province of Biella, where a yearling male in poor condition infested with Hypoderma diana was observed. In the perspective that the restoration of species-specific parasite communities of native mammals in Europe is increasingly perceived as a conservation target, with similar dignity as the conservation of their hosts, baseline data presented in this communication may give new insights for future parasite conservation efforts.
Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools
Authors: Weinelt Ferdinand Anton , Stegemann Miriam Songa , Theloe Anja , Pfäfflin Frieder , Achterberg Stephan , Weber Franz , Dübel Lucas , Mikolajewska Agata , Uhrig Alexander , Kiessling Peggy , Huisinga Wilhelm , Michelet Robin , Hennig Stefanie , Kloft Charlotte
Published: June 2022

The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets. To reliably achieve the targeted concentrations, dosing needs to be adjusted for renal function. We aimed to evaluate a meropenem and piperacillin/tazobactam monitoring program in intensive care unit (ICU) patients by assessing (i) the adequacy of locally selected empirical targets, (ii) if dosing is adequately adjusted for renal function and individual target, and (iii) if dosing is adjusted in target attainment (TA) failure. In a prospective, observational clinical trial of drug concentrations, relevant patient characteristics and microbiological data (pathogen, minimum inhibitory concentration (MIC)) for patients receiving meropenem or piperacillin/tazobactam treatment were collected. If the MIC value was available, a target range of 1–5 × MIC was selected for minimum drug concentrations of both drugs. If the MIC value was not available, 8–40 mg/L and 16–80 mg/L were selected as empirical target ranges for meropenem and piperacillin, respectively. A total of 356 meropenem and 216 piperacillin samples were collected from 108 and 96 ICU patients, respectively. The vast majority of observed MIC values was lower than the empirical target (meropenem: 90.0%, piperacillin: 93.9%), suggesting empirical target value reductions. TA was found to be low (meropenem: 35.7%, piperacillin 50.5%) with the lowest TA for severely impaired renal function (meropenem: 13.9%, piperacillin: 29.2%), and observed drug concentrations did not significantly differ between patients with different targets, indicating dosing was not adequately adjusted for renal function or target. Dosing adjustments were rare for both drugs (meropenem: 6.13%, piperacillin: 4.78%) and for meropenem irrespective of TA, revealing that concentration monitoring alone was insufficient to guide dosing adjustment. Empirical targets should regularly be assessed and adjusted based on local susceptibility data. To improve TA, scientific knowledge should be translated into easy-to-use dosing strategies guiding antibiotic dosing.
Proteomic Comparison of Ivermectin Sensitive and Resistant Staphylococcus aureus Clinical Isolates Reveals Key Efflux Pumps as Possible Resistance Determinants
Authors: Ashraf Shoaib , Parrine Débora , Bilal Muhammad , Chaudhry Umer , Lefsrud Mark , Zhao Xin
Published: June 2022

Ivermectin (IVM) is a versatile drug used against many microorganisms. Staphylococcus aureus is one of the most devastating microorganisms. IVM sensitive and resistant S. aureus strains were recently reported. However, the underlying molecular mechanisms of resistance are unknown. Clinical isolates of S. aureus were used for determination of the sensitivities against IVM by growth curve analysis and time-kill kinetics. Then, proteomic, and biochemical approaches were applied to investigate the possible mechanisms of resistance. Proteomic results showed a total of 1849 proteins in the dataset for both strains, 425 unique proteins in strain O9 (IVM sensitive), and 354 unique proteins in strain O20 (IVM resistant). Eight proteins with transport functions were differentially expressed in the IVM resistant strain. Among them, three efflux pumps (mepA, emrB, and swrC) were confirmed by qPCR. The IVM resistant S. aureus may overexpress these proteins as a key resistance determinant. Further experiments are required to confirm the exact mechanistic relationship. Nevertheless, the possibility of blocking these transporters to reverse or delay the onset of resistance and reduce selection pressure is potentially appealing.
Impact of Pharmacist-Led Implementation of a Community Hospital-Based Outpatient Parenteral Antimicrobial Therapy on Clinical Outcomes in Thailand
Authors: Thomnoi Teeranuch , Komenkul Virunya , Prawang Abhisit , Santimaleeworagun Wichai
Published: June 2022

Few studies have analyzed community hospital-based parenteral anti-infective therapy (CohPAT). We aimed to assess the clinical impact of a pharmacist-led implementation of a clinical practice guideline (CPG) for CohPAT, and to determine the pharmacist’s role in CohPAT medication management. The prospective-period patients (post-implementation group) were compared with the historical control-period patients (pre-implementation group) for receiving a continuous antimicrobial parenteral injection. A CPG was used for laboratory testing for efficacy and safety, the monitoring of adverse drug events during admission, microbiology results coordination, and dosage adjustment. For any antimicrobial drug-related problems, the pharmacist consulted with the clinicians. Over 14 months, 50 participants were included in each group. In the pre-implementation period, 7 (14%) and 4 (8%) out of 50 patients received an inappropriate dosage and nonlaboratory monitoring for dose adjustment, respectively. The patients received the proper dosage of antimicrobial agents, which increased significantly from 78% pre- to 100% post-implementation (p = 0.000). The pharmacist’s interventions during the prospective-period were completely accepted by the clinicians, and significantly greater laboratory monitoring complying with CPG was given to the postimplementation group than the pre-implementation group (100% vs. 60%; p = 0.000). Significantly less patients with unfavorable outcomes (failure or in-hospital mortality) were observed in the post-implementation than in the pre-implementation (6% vs. 26%; p = 0.006) group. For the logistic regression analysis, lower respiratory infection (adjusted OR, aOR 3.68; 95%CI 1.13–12.06) and the post-implementation period (aOR 0.21; 95%CI 0.06–0.83) were significant risk factors that were associated with unfavorable outcomes. Given the better clinical outcomes and the improved quality of septic patient care observed after implementation, pharmacist-led implementation should be adopted in healthcare settings.
Platelet CD40L Expression Response to Mixing of pRBCs and Washed Platelets but no Causality Association between Platelet ROS Generation and CD40L Expression: An In Vitro Study
Authors: Hu Mei-Hua , Huang Tien-Yu , Chou Yu-Ching , Huang Go-Shine
Published: June 2022

Platelets play a role in transfusion reaction via reactive oxygen species (ROS) generation and CD40 ligand (CD40L) expression. In this study, we aimed to test the hypothesis that the mixing of packed red blood cells (pRBCs) and washed platelets has a causal effect on platelet ROS generation and CD40L expression. Thus, a better understanding of this causality relationship may help interrupt the chain of events and avoid an uncontrollable transfusion reaction. We simulated transfusion in vitro by mixing pRBCs and washed platelets. Donor cross-matched stored pRBCs) from our blood bank and recipient whole blood from patients undergoing coronary artery bypass graft surgery prepared into washed platelets were used. Briefly, donor pRBCs were added to washed recipient platelets to form 1%, 5%, or 10% (v/v) mixtures. The mixed blood sample was used to determine platelet ROS generation (dichlorofluorescein fluorescence levels) and CD40L expression. The effect of antioxidants (20 mM glutamine and 20 mM dipeptiven) on ROS generation and CD40L expression was also evaluated. Platelet ROS generation was not significantly associated with the mixing of pRBCs and washed platelets (p = 0.755), glutamine treatment (p = 0.800), or dipeptiven treatment (p = 0.711). The expression of CD40L by platelets increased significantly (p < 0.001), and no significant difference was noted after treatment with glutamine (p = 0.560) or dipeptiven (p = 0.618). We observed that the mixing pRBCs and washed platelets had no effect via ROS, whereas CD40L could directly induce transfusion reactions. Furthermore, platelets did not causally express ROS or CD40L after being mixed with pRBCs. Although antioxidants are more accessible than anti-CD40L antibodies, platelet ROS may not serve as a therapeutic target for antioxidants. Nevertheless, CD40L expression may be a valuable therapeutic target for managing transfusion reactions.
Application of Multi-Objective Hyper-Heuristics to Solve the Multi-Objective Software Module Clustering Problem
Authors: Alshareef Haya , Maashi Mashael
Published: June 2022

Software maintenance is an important step in the software lifecycle. Software module clustering is a HHMO_CF_GDA optimization problem involving several targets that require minimization of module coupling and maximization of software cohesion. Moreover, multi-objective software module clustering involves assembling a specific group of modules according to specific cluster criteria. Software module clustering classifies software modules into different clusters to enhance the software maintenance process. A structure with low coupling and high cohesion is considered an excellent software module structure. In this study, we apply a multi-objective hyper-heuristic method to solve the multi-objective module clustering problem with three objectives: (i) minimize coupling, (ii) maximize cohesion, and (iii) ensure high modularization quality. We conducted several experiments to obtain optimal and near-optimal solutions for the multi-objective module clustering optimization problem. The experimental results demonstrated that the HHMO_CF_GDA method outperformed the individual multi-objective evolutionary algorithms in solving the multi-objective software module clustering optimization problem. The resulting software, in which HHMO_CF_GDA was applied, was more optimized and achieved lower coupling with higher cohesion and better modularization quality. Moreover, the structure of the software was more robust and easier to maintain because of its software modularity.
Squirrel Search Optimization with Deep Transfer Learning-Enabled Crop Classification Model on Hyperspectral Remote Sensing Imagery
Authors: Hamza Manar Ahmed , Alrowais Fadwa , Alzahrani Jaber S. , Mahgoub Hany , Salem Nermin M. , Marzouk Radwa
Published: June 2022

With recent advances in remote sensing image acquisition and the increasing availability of fine spectral and spatial information, hyperspectral remote sensing images (HSI) have received considerable attention in several application areas such as agriculture, environment, forestry, and mineral mapping, etc. HSIs have become an essential method for distinguishing crop classes and accomplishing growth information monitoring for precision agriculture, depending upon the fine spectral response to the crop attributes. The recent advances in computer vision (CV) and deep learning (DL) models allow for the effective identification and classification of different crop types on HSIs. This article introduces a novel squirrel search optimization with a deep transfer learning-enabled crop classification (SSODTL-CC) model on HSIs. The proposed SSODTL-CC model intends to identify the crop type in HSIs properly. To accomplish this, the proposed SSODTL-CC model initially derives a MobileNet with an Adam optimizer for the feature extraction process. In addition, an SSO algorithm with a bidirectional long-short term memory (BiLSTM) model is employed for crop type classification. To demonstrate the better performance of the SSODTL-CC model, a wide-ranging experimental analysis is performed on two benchmark datasets, namely dataset-1 (WHU-Hi-LongKou) and dataset-2 (WHU-Hi-HanChuan). The comparative analysis pointed out the better outcomes of the SSODTL-CC model over other models with a maximum of 99.23% and 97.15% on test datasets 1 and 2, respectively.
Quantum Natural Language Processing: Challenges and Opportunities
Authors: Guarasci Raffaele , De Pietro Giuseppe , Esposito Massimo
Published: June 2022

The meeting between Natural Language Processing (NLP) and Quantum Computing has been very successful in recent years, leading to the development of several approaches of the so-called Quantum Natural Language Processing (QNLP). This is a hybrid field in which the potential of quantum mechanics is exploited and applied to critical aspects of language processing, involving different NLP tasks. Approaches developed so far span from those that demonstrate the quantum advantage only at the theoretical level to the ones implementing algorithms on quantum hardware. This paper aims to list the approaches developed so far, categorizing them by type, i.e., theoretical work and those implemented on classical or quantum hardware; by task, i.e., general purpose such as syntax-semantic representation or specific NLP tasks, like sentiment analysis or question answering; and by the resource used in the evaluation phase, i.e., whether a benchmark dataset or a custom one has been used. The advantages offered by QNLP are discussed, both in terms of performance and methodology, and some considerations about the possible usage QNLP approaches in the place of state-of-the-art deep learning-based ones are given.
An Easy Technique for Focus Characterization and Optimization of XUV and Soft X-ray Pulses
Authors: Muschet Alexander A. , De Andres Aitor , Smijesh N. , Veisz Laszlo
Published: June 2022

For many applications of extreme ultraviolet (XUV) and X-ray pulses, a small focus size is crucial to reach the required intensity or spatial resolution. In this article, we present a simple way to characterize an XUV focus with a resolution of 1.85 µm. Furthermore, this technique was applied for the measurement and optimization of the focus of an ellipsoidal mirror for photon energies ranging from 18 to 150 eV generated by high-order harmonics. We envisage a broad range of applications of this approach with sub-micrometer resolution from high-harmonic sources via synchrotrons to free-electron lasers.
Mechanical-Empirical Pavement Design Guide Applied to Portuguese Pavement Structures
Authors: Justo-Silva Rita , Simões Fábio , Ferreira Adelino
Published: June 2022

This paper describes the characteristics of the new pavement design method developed by the American Association of State Highway and Transportation Officials (AASHTO), known as AASHTOWare Pavement-ME®, and presents the results of its application to the flexible pavement structures presented in the Portuguese Manual of Pavement Structures for the national road network. The results obtained clearly show that it is a very useful tool for road engineers not only for designing new pavement structures but also for the analysis of their performance and for efficiently planning maintenance and rehabilitation interventions. According to the characteristics of the case study that was considered, rutting is the most critical distress, since it presents values close to its threshold value of 20.0 mm, a value that is defined in Portuguese Quality Control Plans.
An Improved Gas Leakage Model and Research on the Leakage Field Strength Characteristics of R290 in Limited Space
Authors: Li Yalun , Zhou Peixu , Zhuang Yuan , Wu Xilei , Liu Ying , Han Xiaohong , Chen Guangming
Published: June 2022

Some alternative refrigerants with excellent environmental performance often have different flammable limits. When refrigerant leaks, the external space may have a certain explosion risk if the refrigerant is not diffused timely. To understand the leakage and diffusion characteristics of the refrigerant, an improved gas leakage model was proposed in this paper, and the accuracy verification of the improved model was developed. Based on the above works, taking R290 as the research object, the variation law of the field strength between the leaked gas and external space and the influence of different initial leakage pressures on the field strength characteristics were analyzed. The simulation results showed that when the initial leakage pressure was 2 MPa, the R290 gas entered the external space as a supersonic jet, the gas underwent continuous expansion and compression processes in the near-field area and a Mach disk was formed within the flow area. During this process, parameters, such as the temperature, pressure, velocity and density of the leaked R290 gas, changed dramatically, and then the gas gradually returned to room temperature and normal pressure through interaction with the external space. The flammable area formed by the leaked R290 was mainly concentrated in the local flow area below the leak hole, and the existence of the Mach disk caused the R290 high concentration area to increase. With the increase in the initial leakage pressure, the distance from the Mach disk to the leak hole and the circumferential diameter of the Mach disk increased, and the flammable area increased slightly in the horizontal direction, whereas the flammable area increased significantly in the vertical direction.
Diagnosing the Machine Set Rotor Using Its Relative Vibrations
Authors: Bielawski Piotr Jan
Published: June 2022

The efficiency and dependability of machine set depends on the quality of maintenance of functional units of the machine set rotor. Diagnosing the functional units of the machine set can significantly increase the effectiveness and efficiency of the maintenance of the machine set. The purpose of the study was to substantiate the separation of the machine set rotor and demonstrate the possibility of diagnosing such a functional unit using non-contact measurements of its relative vibrations. The measure of the wear margin of the machine set rotor was analyzed, and the symptoms of this measure were examined. Finally, the configuration of the relative vibration sensors of the machine set rotor was investigated. Three models of the relationship between the wear margin measures and the measures of the machine set rotor symptoms were developed for the machine set rotor with a crankshaft supported in slide bearings. One new sensors head (shaft position sensors head) of the relative vibration of the machine set rotor was designed. In each machine set, the rotor of the machine set can be distinguished. The developed models of relationships and designed sensors head can be used as parts of the diagnostic system of the supported slide bearings rotor of the machine set with the crankshaft.
Pyrolysis Process for the Recycling of Cork Dust Waste from the Processing of Cork Agglomerate Caps in Lightweight Materials
Authors: Coppelli Paride , Pedrazzi Simone , Puglia Marco , Morselli Nicolò , Allesina Giulio , Andreola Fernanda , Lancellotti Isabella , Barbieri Luisa
Published: June 2022

This study aimed to investigate the possibility of recycling cork scraps derived from the production of agglomerated bottle caps containing organic additives (glues and adhesives) in addition to virgin wood. The study involved pyrolysis treatment followed by the use of char to obtain lightweight material prototypes. The scrap was pyrolysed in order to achieve the thermal degradation of unwanted molecules with decomposition temperatures lower than the pyrolysis temperatures, but also to achieve the reduction in mass and size of the starting material. The substitution of 15% by weight of weight-lightening agent (char from pyrolysed cork, or half char and half spent coffee grounds) into the clayey matrix made it possible to obtain lightweight aggregates with pH and conductivity values that could be exploited in an agronomic context. The substitution of clay with of 5 to 15% by weight of pyrolysed cork char in the production of specimens pressed at 25 bar and fired slowly at 1000 °C led to lightweight ceramics with particularly interesting porosity (from 41 to 68%) and bulk density (850–1600 kg/m3) values.
Nondestructive Surface Crack Detection of Laser-Repaired Components by Laser Scanning Thermography
Authors: Geng Chuanqing , Shi Wenxiong , Liu Zhanwei , Xie Huimin , He Wei
Published: June 2022

As a revolutionary new technique, laser-engineered net shaping (LENS) is a layer additive manufacturing process that enables accurate, rapid and automatic repair of industrial component damage. In the laser repair (LR) process or in service, surface cracks can appear, which have a detrimental effect on the repair quality and the mechanical performance; therefore, the surface crack detection of repaired components has attracted much attention. Laser spot thermography is an important nondestructive testing method with the advantages of non-contact, full-field and high precision, which shows great potential in the crack detection of repaired components. The selection of thermographic process parameters and the optimization of thermal image processing algorithms are key to the success of the nondestructive detection. In this paper, the influence of material properties and thermographic process parameters on the surface temperature gradient is studied based on the simulation of laser spot thermal excitation, and the selection windows of thermographic process parameters for iron-based and nickel-based alloys are obtained, which is applied to the surface crack detection of repaired components. To improve the computational efficiency of thermal images, the Prewitt edge detection algorithm is used in the thermal image processing, which realized fast extraction of cracks with a high signal-to-noise ratio (SNR), and the detection sensitivity of crack width can reach 10 μm. To further study the influence of surface roughness on the thermographic detection, repair layers with and without polishing process are characterized, which show that the Prewitt edge detection algorithm is well applicable to crack detection on surfaces with different roughness level.
Numerical Simulation of a Fire Accident in a Longitudinally Ventilated Railway Tunnel and Tenability Analysis
Authors: Zisis Thomas , Vasilopoulos Konstantinos , Sarris Ioannis
Published: June 2022

The present study examines the prevailing conditions in a railway tunnel after a train fire accident and the ability of the ventilation system to create the proper conditions for a safe passenger evacuation. The examined scenario included an event of a 20-MW diesel pool fire on a suburban train, immobilized in the middle of a 1.5-Km long, linear shaped rectangular tunnel ventilated by a longitudinal jet fan system, and the people’s movement during the evacuation was effectuated along walking platforms. More specifically, three scenarios with different fan activation times and different evacuation processes were examined. A Large Eddy simulation model (LES) was used for the simulation of the air flow in the railway tunnel. The evaluation of the ventilation system criteria considered the achievement of the air critical velocity inside the railway tunnel, and for the people’s safe evacuation, the Fractional Effective Dose (FED) value was examined. It was found that the most important action in a tunnel fire is the time, after the start of a fire, the ventilation system is activated.