bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on return to work for colorectal cancer survivors: A bibliometric analysis
Authors: Hu Dan , Zhang Hua , Wang Lianlian , Liu Wenwen , Yang Xin , Li Juan
Published: January 2023

Purpose
Colorectal cancer survivors’ returning to work is a symbol of recovery as well as back to society. However, few studies have explored the study orientation for this domain. A bibliometric analysis of this field is urgently needed.
Methods
The database of Web of Science Core Collection was utilized to search publications. Characteristics of literature including publication years, countries, institutions, journals and authors were analyzed. VOSviewer and CiteSpace were utilized for data visualization. The data search and analysis were conducted on May 11, 2022.
Results
Totally, 125 articles were identified. The article number has grown gradually in the last twenty years. The League of European Research Universities and author De Boer Agem from the Netherlands contribute most in this field. The Journal of Supportive Care In Cancer issued the utmost articles, and the journal of Psycho Oncology outranked other journals with citations suggesting that it serves as the landmark journal. Outcomes, employment & financial burden, health & barriers and quality of life & rehabilitation are high-frequency keywords in co-occurrence analysis. Burst analysis revealed that experience, financial burden, risk factors, symptoms distress (fatigue), unemployment and physical activity studies were the emerging hot spots in the domain. The management of return to work after colorectal cancer is multidisciplinary.
Conclusions
The understanding of returning to work for colorectal cancer patients has improved increasingly over the two decades. The author De Boer Agem from the Netherlands and the Journal of Supportive Care In Cancer made the largest contribution to this domain. More attention should be paid to experience, financial burden, risk factors, symptoms of distress (fatigue), unemployment, and intervention studies. Multidisciplinary integration is the essence.
Agreement between cardiac output estimation with a wireless, wearable pulse decomposition analysis device and continuous thermodilution in post cardiac surgery intensive care unit patients
Authors: Khanna Ashish K. , Garcia Julio O , Saha Amit K , Harris Lynnette , Baruch Martin , Martin R. Shayn
Published: January 2023

Purpose
Pulse Decomposition Analysis (PDA) uses integration of the systolic area of a distally transmitted aortic pulse as well as an arterial stiffness estimate to compute cardiac output. We sought to assess agreement of cardiac output (CO) estimation between continuous pulmonary artery catheter (PAC) guided thermodilution (CO-CCO) and a wireless, wearable non-invasive technology that utilizes the Pulse Decomposition Analysis (CO-PDA) method in post-operative cardiac surgery patients.
Methods
Post processed CO-CCO measurements were compared with CO-PDA measurements in prospectively enrolled adult cardiac surgical intensive care unit patients. Both calibrated and uncalibrated CO-PDA values were compared for accuracy with CO-CCO via a Bland-Altman analysis considering repeated measurements and a concordance analysis with a 10% exclusion zone.
Results
259.7 hours of monitoring data from 41 patients matching 15583 data points was analyzed. Mean CO-CCO was 5.55 L/min, while mean values for the uncalibrated CO-PDA were 5.73 L/min (bias +- precision 0.79 ± 1.11 L/min; limits of agreement − 1.43 to 3.01 L/min) and for the calibrated CO-PDA were 5.60 L/min (bias +- precision 0.22 ± 1.03 L/min; limits of agreement − 1.86 to 2.26 L/min). The percentage errors were 37.5% (uncalibrated) and 35.0% (calibrated). CO-CCO correlation with CO-PDA was moderate (0.54 and 0.67, respectively) and concordance was 0.83.
Conclusion
Cardiac output measured with the CO-PDA agrees with the commonly used CO-CCO PAC continuous thermodilution method. These devices are not interchangeable when using a 30% error threshold though the CO-PDA offers a non-invasive, wireless solution to complement and extend hemodynamic monitoring within and outside the ICU.
Serum peptides as candidate biomarkers for relapsing polychondritis
Authors: Sato Toshiyuki , Sato Masaaki , Nagai Kouhei , Fukasawa Masahiko , Nagashima Yoshiaki , Uchida Teisuke , Tsutiya Atsuhiro , Omoteyama Kazuki , Arito Mitsumi , Takakuwa Yukiko , Ooka Seido , Suematsu Naoya , Kawahata Kimito , Yamano Yoshihisa , Kato Tomohiro , Kurokawa Manae S.
Published: January 2023

Background:For relapsing polychondritis (RP), no useful biomarkers have yet been identified. We analyzed serum peptide profiles to identify candidate biomarkers.Methods:Patients with RP or rheumatoid arthritis (RA) and healthy control (HC) subjects were divided into training set (RP, n=19; RA, n=21; HC, n=17) and testing set (RP, n=18; RA, n=21; HC, n=18). Seven patients demonstrating granulomatosis with polyangiitis (GPA) were used for validation. The ion intensity of serum peptides was comprehensively measured by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry.Results:One hundred sixty serum peptides were detected. In the RP group of the training set, 24, 8, and 7 peptides showed a ³1.2-fold difference in ion intensity in comparison to the HC, RA, and HC+RA (non-RP) groups, respectively (p<0.05). Based on a supervised multivariate analysis of the ion intensity of 160 peptides, we generated 3 models that completely discriminated the RP group from the HC, RA, and non-RP groups (RP/HC-160P model, RP/RA-160P model, and RP/nonRP-160P model; AUROC, 1.000). By selecting 11, 9, and 14 peptides, the RP group was also completely discriminated from the 3 groups (RP/HC-11P model, RP/RA-9P model, and RP/nonRP-14P model; AUROC, 1.000). We attempted to identify the peptides with a ³1.2-fold difference in ion intensity between the RP group and one of the 3 groups and the peptides comprising the RP/HC-11P, RP/RA-9P or RP/nonRP-14P models. Nineteen peptides were identified. Most were fragments of proteins associated with coagulation. To obtain biomarker models for RP which consists of a few peptides, we further generated 330 models, using all combinations of 3 or 4 peptides out of the 10 identified peptides of the RP/nonRP-14P model. Among them, 69 models provided ³65.0% sensitivity and specificity in the training set (AUROC, 0.789-0.823). In the testing set and the testing set with GPA group, 4 models consisting of 4 peptides (RP/nonRP-4P-2, -10, -11, and -38 models) provided ³70.0% sensitivity and specificity (AUROC, 0.779-0.815). Notably,the RP/nonRP-4P-2 model provided 83.3% sensitivity and 71.7% specificity in the testing set with GPA group (AUROC, 0.802).Conclusion:Serum peptide proﬁles provided useful candidate biomarkers for RP and may be implicated in the pathophysiology of RP.Trial registration:University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), UMIN 000037212. Registered on 30 June 2019.
RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: A case report and review of the literature
Authors: Kabootari Maryam , Tirtashi Reza Habibi , Zadeh-Vakili Azita , Zarkesh Maryam , Samadanifard Hossein , Azizi Fereidoun , Amouzegar Atieh
Published: January 2023

Background: Struma ovarii refers to rare mature cystic teratomas containing at least 50% of thyroid tissue, and malignant transformation is known to be even rarer. The synchronous development of malignant struma ovarii and cervical thyroid carcinoma are also scarce and poorly understood due to limited data about molecular features. Here, we present the first report of RET/PTC 1 rearrangement in synchronous metastatic malignant struma ovarii to the abdominal wall and cervical thyroid cancer.
Case presentation: We described a 47-year-old multigravida woman with bilateral adnexal and lower abdominal wall masses detected during the evaluation of abnormal uterine bleeding. The patient underwent a hysterectomy, bilateral salpingo-oophorectomy, and surgical removal of abdominal wall mass. Then, the pathological evaluation revealed papillary thyroid carcinoma (PTC) within struma ovarii and metastatic PTC in the abdominal wall fibro adipose tissue. Further, cervical thyroid gland physical examination and ultrasound illustrated a nodule within the left lobe. Subsequently, a total thyroidectomy was performed, and a histological examination revealed PTC. Furthermore, all affected tissue, i.e., struma ovarii, abdominal wall metastasis, and cervical thyroid gland tested for BRAF and RAS mutations and RET/PTC 1 rearrangement. RET/PTC 1 rearrangement was identified among all three different sites. Finally, after six years of follow-up, the patient had no evidence of recurrence or distant metastasis.
Conclusions: In light of these findings, malignant struma ovarii might yield a clue to cervical thyroid carcinoma, and the molecular analysis could provide valuable information for understanding the underlying mechanism, tumor clinicopathological behaviors, and prognosis.
Scale-dependent release of Borrelia burgdorferi sensu lato infected Ixodes ricinus larvae from vertebrates
Authors: Takumi Katsuhisa , Holding Maya Louise , Fabri Nannet D. , Sprong Hein , Heylen Dieter
Published: January 2023

Background:The multi-host tickIxodes ricinusis the principal vector of zoonotic diseases in Europe. Quantifying the contribution of each host species in the tick’s pathogen transmission cycles is imperative in spatio-temporal pathogen exposure assessments, but remains challenging in the absence of techniques identifying the previous host on which (infectious) host-searching ticks have fed. Based on European literature data, we here investigate the capacity of vertebrate species to infect naïve larvae with particularBorreliagenospecies belonging to the multi-host pathogen complexBorrelia burgdorferisensu lato (the causative agent of Lyme Borreliosis in humans).Methods:We calculated the number of infected larvae generated by an infectious host. This measure (‘realized release’) was subsequently used to investigate intrinsic host infectiousness (through adjustment for tick exposure), lifetime release, and spatial dilution. Host abundances from naturally occurring vertebrate communities were subsequently used to estimate their local contributions to the population of infectious host-searching nymphs.Results:Thirty-one vertebrates were identified as amplifying hosts; vertebrate species that successfully generate larvae infected with aBorreliagenospecies. In 1-ha forest plots, per genospecies one vertebrate species released a disproportional amount of infected larvae. Several bird species show (high) infectiousness for non-avian genospecies:B. lusitaniae,B. burgdorferisensu stricto andB. afzelii. At population level, due to their smaller home ranges in combination with higher densities and tick exposures, several mammal species locally intensely contributed to mammalian genospecies (B. afzelii,B. burgdorferis.s. andB. bavariensis). In contrasts, due to their larger home ranges and lower tick exposure, the birds’ local contributions were more restricted – this despite their higher intrinsic infectiousness (reservoir competence). Given their seemingly lower specificity in amplification, birds are the main driver in the maintenance of pathogen diversity across macro-geographic scales.Conclusions:Ecological factors that affect the infection pressures and reservoir competence are still poorly understood in one of the best-studied tick-borne zoonoses (B. burgdorferis.l.). To anticipate current rapidly changing abiotic environmental conditions – inevitably affecting tick exposures and zoonotic risks - we advocate the generation of field-experimental data on host reservoir competence based on larval infections.
Cementless total hip arthroplasty for treatment of acetabular protrusion secondary to rheumatoid arthritis
Authors: liu peng , Qiao yongjie , Lou jinpeng , Cao guoding , Chang yanfeng , Zhen ping , zhang haoqiang , 周 胜虎
Published: January 2023

Background: To explore the surgical technique and clinical outcomes of cementless total hip arthroplasty (THA) combined with impacted bone grafting in treating moderate and severe acetabular protrusion with rheumatoid arthritis (RA).
Methods: From January 2010 to October 2020, 45 patients (56 hips) with RA secondary to acetabular invagination were treated with biological prosthesis THA combined with autologous bone grafting in our hospital, including 17 males (22 hips) and 28 females (34 hips). According to Sotello-Garza and Charnley classification criterion, there were 40 cases（49 hips）of typeⅡ(protrusio acetabuli 6-15 mm), and 5 cases（7 hips）of type Ⅲ (protrusio acetabuli ＞15 mm). At the postoperative follow-up, the ROM of the hip joint, the VAS score, and the Harris score were evaluated. The healing of the bone graft, the restoration of the hip rotation center, and the prosthesis loosening were assessed by plain anteroposterior radiographs.
Results: The average operation time was 95.53 ± 22.45 min, and the mean blood loss was 156.16 ± 69.25 mL. There were no neurovascular complications during the operation. The mean follow-up duration was 5.20 ± 1.20 years. The horizontal distance of the hip rotation center was increased from preoperative 10.40 ± 2.50 mm to postoperative 24.03 ± 1.77 mm, and the vertical distance was increased from preoperative 72.36 ± 3.10 mm to postoperative 92.48±5.31 mm. The range of flexion motion of the hip joint increased from 39.48 ± 8.36° preoperatively to 103.07 ± 7.64° postoperatively, and the range of abduction motion increased from 10.86 ± 4.34° preoperatively to 36.75 ± 3.99° postoperatively. At the last follow-up, the Harris score increased from 37.84 ± 4.74 to 89.55 ± 4.05. All the patients could move independently without assistance.
Conclusions: Cementless THA combined with impacted grafting granule bone of the autogenous femoral head and biological acetabular cup can reconstruct the acetabulum, restore the rotation center of the hip joint, and achieve good medium-term outcomes in the treatment of moderate and severe acetabular protrusion secondary to RA.
Information Extraction System for Cargo Invoices
Authors: Tan QiuXing Michelle , Cao Qi , Seow Chee Kiat , Yau Peter Chunyu
Published: January 2023

Rapid growth in the digitization of documents, such as cargo invoices or receipts, has alleviated the demand for methods to process information accurately and efficiently. However, it has become impractical for humans to extract the data due to the size of the corpus. Furthermore, extracting the information manually can be labor-intensive and time-consuming as employees need to go through multiple digitized invoices and extract the critical information. The digital documents, such as digital cargo invoices contain various components such as tables, key-value pairs and figures. Existing optical character recognition (OCR) method are able to recognize texts. But it is challenging for them to extract the key-value pairs in unformatted digital cargo invoices. Hence, creating a smart information extraction system that can extract key-value pairs would be beneficial, as it would help organizations achieve workflow efficiency, resource utilization and eliminate costly errors. In this paper, a pipeline of the information extraction system is proposed with deep learning approaches for classifying key-value pairs first, followed by linking the key-value pairs. Two merging rules and two pairing rules are developed in the proposed pipeline. Various experiments have been conducted to illustrate the performance of the system.
Drug Design, Molecular Docking and Dynamics Studies on the Interaction of Voxelotor, L- Glutamine and Hydroxy Urea with Human Carbonmonoxy Hemoglobin S
Authors: Jibrin Anne , Uzairu Adamu , Shallangwa Gideon Adamu , Abechi Stephen Eyije , Umar Abdullahi Bello
Published: January 2023

Sickel cell disease (SCD) is a defect in hemoglobin structure that leads to deficiency in oxygen transfer in the body. Voxelotor, L- Glutamine and Hydroxyurea are three out of the four drugs approved by the FDA to treat SCD, yet the disease is incurable. The medical community are searching for new drug and new drug target that can cure or inhibit the product of this disease. In this research, we used molecular docking, molecular dynamics (MD) simulation and ADMET studies to analyze the interactions of these drugs. MD potential of the three drugs into the active site of hemoglobin S was investigated. Voxelotor has the highest score, with a binding energy of -21.66 kcalmol-1. Out of the Eight new drug designed based on the backbone of Voxelotor, it was found out that Vox8 has the best binding energy of -24.73 kcalmol-1, followed by Vox7 with binding energy of -22.30 kcalmol-1 and Vox4 with -21.81 kcalmol-1 respectively. The docking results were validated with the aid of MD simulations, the results revealed that the complex of the ligand and the receptor protein is stable at 300K. For the prediction of blood-brain barrier penetration, the SwissADMET web based service was able to predict the BBB profile for the designed drugs, Lipinski’s rule was obeyed, bioavailability Score were good which led to the understanding of the biological activities of the compounds.
KIF5A inhibition ferroptosis in Parkinson's disease
Authors: Wu Peipei , Wu Chunxiao , Han Jiajun , Huang Zifeng , Hao Xiaoqian , Zhao Lijun , Chen Dongfeng , Zhu Meiling
Published: January 2023

Parkinson's disease (PD) is a highly prevalent neurodegenerative disorder associated with abnormal brain iron metabolism. Ferroptosis is a newly discovered form of iron-dependent cell death. In recent years, many studies have identified ferroptosis as an important pathogenic mechanism of PD. Nevertheless, the underlying mechanisms remain unclear. A 6-hydroxydopamine (6-OHDA) stimulated the PD rat model and the PD cell model were used in this research. The experimental results showed that the level of kinesin 1 heavy chain (KIF5A) decreases, and the level of ferroptosis increases after 6-OHDA stimulation. A PD cell model is consistent with these results. The overexpression of KIF5A in SH-SY5Y cells significantly reduces intracellular lipid peroxidation, Fe2+ accumulation, and ferroptosis. In contrast, knockdown of KIF5A exacerbated lipid peroxidation and Fe2+ accumulation, and cellular ferroptosis was more severe. Therefore, this study provides new views and potential for studying treatment targets of PD by demonstrating that KIF5A protects cells from ferroptosis in a PD model.
Modeling and mechanistic approach for acid red 88 dye removal by hydrothermally synthesized magnetic chitosan-grafted with side chain salicylaldehyde
Authors: Hapiz Ahmad , Arni Laili Azmiati , Khadiran Tumirah , ALOthman Zeid A. , Wilson Lee D. , Jawad ALI H.
Published: January 2023

This research used the hydrothermal process to cross-link biopolymer magnetic chitosan (CS/Fe3O4) with an aromatic aldehyde (salicylaldehyde, SA) for the adsorption of acidic azo dye (AR88) from an aqueous environment. Analyses of VSM, pHpzc, CHNS, XRD, SEM-EDX, FTIR, and BET were used to determine the properties of CS-SL/Fe3O4 material. Using the Box-Behnken design (BBD), the effects of A: CS-SL/Fe3O4 dose range from 0.02–0.1 g, B: [AR88] concentration (10–50 mg/L), C: pH (4–10), and D: duration (10–90 min) on the adsorption performance of CS-SL/Fe3O4 toward AR88 dye were systematically investigated. In this research, the Freundlich isotherm and pseudo-second-order kinetic models were applicable to describe the adsorption rate of AR888 molecules. The maximum adsorption capacity (qmax) of the hydrothermally cross-linked CS-SL/Fe3O4 for AR88 dye was 137.3 mg/g. Multiple mechanisms, including electrostatic attraction, π-π stacking, n-π interaction, and H-bonding, are responsible for AR88 adsorption by CS-SL/Fe3O4. This study demonstrates that hydrothermal preparation of cross-linked CS-SL/Fe3O4 offers an effective and promising adsorbent for removing acidic dyes from polluted water.
Novel association of SMARCA4 deletion with Dermatofibrosarcoma protuberans: Novel insights and expansion of the molecular change of this tumour
Authors: Deng Huiyan , Jia Ying , Jia Keqi , Fan Xiaojie , Liu Yueping
Published: January 2023

Dermatofibrosarcoma protuberans (DFSP) is a rare indolent soft tissue sarcoma of the skin that accounts for less than 1 % of all soft tissue sarcomas. Clinically, it is a slow-growing, localised, low-grade, malignant fibrosarcoma. Here, we report the case of a 40-year-old woman diagnosed with DFSP harbouring a deletion in the SMARCA4 gene. The tumour was completely removed after surgery and the 1-year follow-up, no recurrence or additional malignancy was observed. Our review of the existing literature suggests that DFSP with a SMARCA4 gene deletion have not been reported to date. This case furthers our understanding on the molecular biology of DFSP for soft tissue sarcomas, which will therefore help clinicians to more accurately assess the prognoses of patients.
Polyoxometalate/carbon black modified glassy carbon electrode for the detection of dopamine
Authors: Liu Xiong , Zhong Cailing , Ji Jun , Yang Wei , Tian Zhengfang , Chen Yichang , Tian Qifeng
Published: January 2023

Dopamine (DA) is a crucial neurotransmitter in the central nervous system (CNS) of human and multicellular animal brains. In this paper, we report for the first time the synthesis of C/PWA composites by doping phosphotungstic acid (PWA) on carbon black nanoparticles by impregnation method. The synthesized materials were characterized and corroborated using high-resolution scanning electron microscopy, X-ray diffraction spectroscopy (XRD) and Fourier transform infrared spectroscopy. The synthesized C/PWA composite modified glassy carbon (GC) electrodes were used as selective electrocatalysts for dopamine (DA) oxidation process. The electrochemical redox behavior of DA was studied with cyclic voltammetry (CV). Under optimized conditions, DA was detected by differential pulse voltammetry (DPV) and the calibration plot showed linearity (R2 = 0.9988) over the range of DA concentrations of 10 µM-600 µM with a detection line of 0.1 µM. The sensor's capability to detect DA in commercial DA injections in real time has been successfully demonstrated.
Pharmacokinetics of Apixaban in Patients Undergoing Pancreaticoduodenectomy (PAP-UP)
Authors: Zheng Richard , Lam Edwin , Altshuler Peter , Crutcher Madison , Lavu Harish , Yeo Charles J. , Stickle Douglas , Leiby Benjamin , Kraft Walter K.
Published: January 2023

Background: The impact of pancreaticoduodenectomy (PD) on absorption of drugs in the duodenum remains largely unknown. We aim to characterize the pharmacokinetics of apixaban in patients who have previously underwent PD.
Methods: A single 10 mg dose of apixaban was administered to four volunteers who underwent PD at least 6 months prior. The maximum plasma apixaban concentration (Cmax) and area under the plasma concentration time-curve (AUC0-24, AUC0-inf) were compared against healthy historical control subjects (N=12). Geometric mean ratios (GMR) with 90% confidence interval (CI) were calculated for determination of comparative bioequivalence.
Results: In PD patients AUC0-24 and AUC0-inf were 1861 and 2080 ng•hr/mL, respectively. The GMRs of AUC0-24 and AUC0-inf between study subjects and healthy controls were 1.27 (90% CI 0.88-1.83) and 1.18 (90% CI 0.82-1.72). The mean Cmax of apixaban was 201 ng/mL (SD 15.6) occurring at a median Tmax of 3.25 hours (range 2.5-4 hours). The GMR of Cmax between study subjects and healthy controls was 1.12 (90% CI 0.77-1.63).
Conclusions: The pharmacokinetic characteristics of apixaban in subjects who have undergone PD are not significantly different from those of healthy controls. No changes in their dosing regimen are recommended.
ClinicalTrials.gov Identifier: NCT04191928
Experimental determination of Rayleigh scattering cross sections at 408 nm
Authors: LIU YANGZHUORAN , HERNÁNDEZ MARIA DOLORES ANDRÉS , GEORGE MIDHUN , BURROWS JOHN PHILIP
Published: January 2023

Accurate knowledge of the Rayleigh scattering cross sections, σRayl, of atmospheric gases as a function of wavelength is required for radiate transfer calculations and also for the calibration of optical systems e.g. high finesse optical cavities. The cavity ring-down spectroscopy (CRDS) is a highly accurate absolute method which enables experimentally determined σRayl to be compared with σRayl n-values calculated for atmospheric gases using knowledge of the refractive index. In this study, CRDS has been applied to measure light extinction and to retrieve highly accurate σRayl of nitrogen, N2, oxygen, O2, argon, Ar, carbon monoxide CO, carbon dioxide, CO2, nitrous oxide, N2O, methane, CH4 molecules and synthetic air (SA) at 408 nm. Experiments using step pressure changes and pressure ramps in three optical cavities were used to retrieve σRayl. These agree on average within 0.6% with the calculated σRayl n-values for CO2, N2O and CH4 and within 2.4%, 1.2%, 2.2%, 1.5%, and 4.1% for N2, O2, SA, Ar and CO respectively. For N2O and CH4, these results confirm experimentally the inaccuracies resulting from extrapolating the refractive index and King correction factors from other wavelength regions to the region around 408 nm, reported elsewhere.
Mortality trend of four major non-communicable diseases in China, 2009-2020
Authors: wu tiantian , wang lianke , hu bo , yao zihui , wang yu , zhang peijia , sun changqing
Published: January 2023

Background
Non-communicable diseases (NCD) have become the leading cause of death in the world at present. Among them, the most important are cardiovascular diseases (CVD), cancer, chronic respiratory diseases and diabetes. This study aimed to analyze the time trends of mortality rates caused by the four major non-communicable diseases (NCD4) in China between 2009 and 2020, and to provide the evidence basis for policy implementation, information system, and health resource management of chronic NCD in China.
Methods
Data on resident death was collected from the National Mortality Surveillance data set and used to analyze the crude mortality rates, standardized mortality rates and changing trends of NCD4 among different genders, urban and rural areas, and geographical regions in China from 2009 to 2020. The Joinpoint Regression Models were fitted by the weighted least squares method. The average annual percent change (AAPC) and its 95% confidence interval (CI) were calculated for the entire time period.
Results
From 2009 to 2020, the standardized mortality from four major NCD combined in China decreased from 534.51 to 395.84%, with the AAPC value at -2.8% (95% CI [-3.7% to -1.8%]). The standardized mortality from CVD, cancer, and chronic respiratory diseases decreased, but the standardized mortality of diabetes increased, with AAPC values at -2.2%, -1.8%, -8.0% and 1.9% respectively.
Conclusions
From 2009 to 2020, the mortality rate of chronic NCD is on the decline, but chronic NCD have become the leading cause of death of residents. Close attention needs to be paid on NCD which affecting the health of the labor force population in China. The prevention and treatment of diabetes, male and west region NCD should be enhanced.
Lamina structure in fine-grained sedimentary rocks: scale, mineral assemblage and well log characterization
Authors: Lai Jin , Zhang Mei , Zhao Fei , Pang Xiaojiao , Zhao Yidi , Li Hongbing , Liu Bingchang , Wang Guiwen
Published: January 2023

A novel method is proposed to characterize the multi-scale lamina structure in fine-grained sedimentary rocks using geophysical well logs. The low limit of individual lamina detection using geophysical well logs is improved to 2.5 mm through image log derived slab image and button conductivity curves. Lamina structure in terms of composition and texture of individual lamina as well as lamina assemblages are determined from core and thin section images. Fine-grained sedimentary rocks are divided into massive, layered and laminated according to core-scale lamina observation. Thin section observation reveals that the mineral composition of individual lamina includes carbonate, silt, clay mineral, tuffaceous lamina and organic matter lamina in the micrometer-scales. The lamina couplets (silt-organic, silt-clay, tuff-organic and carbonate-silt) or triplets (silt-clay-organic) can be classified according to the mineral assemblage. Static and dynamic image logs with 5 mm vertical resolution have low ability to capture the lamina assemblage. Therefore the slab images and button conductivity curves are generated from image logs to facilitate the recognition of laminae. The color patterns (dark-yellow-light-bright) and conductivity values (width of curves) of button conductivity curves can reflect the variations in composition and texture of individual lamina. Core and thin section are calibrated with slab images as well as button conductivity curves to build a method to recognize multi-scale lamina structure. This novel and multidisciplinary approach provides a powerful method for continuously identifying lamina structure with a 2.5 mm vertical resolution using well logs, and have theorical and practical implications for lamina investigation in fine-grained sedimentary rocks.
Spiked solutions for fractional Schrödinger systems with Sobolev critical exponent
Authors: Chen Wenjing , Huang Xiaomeng
Published: January 2023

Note: Please see pdf for full abstract with equations.
In this article, we study the following fractional critical Schrödinger system
(−Δ)sui = μiu3i+ βuiΣj≠i u2j+ λiui in Ω,
ui = 0 on RN \ Ω, i = 1, 2, · · · , m,
where 0 < s < 1, μi > 0, coupling constant β satisfies either −∞ < β ≤ ¯ β ( ¯ β > 0 small) or β → −∞,0 < λi < λs1(Ω), where λs1(Ω) is the first eigenvalue of (−Δ)s on Ω, with Ω is a smooth bounded domain in RN with N = 4s. Under some geometric assumptions on Ω, we construct solutions which concentrate and blow up at different points as λ1, · · · , λm → 0.
2020 Mathematics Subject Classification: Primary 35R11, 35J60; Secondly 47G20.
Involvement of neuropeptidergic neurons in the establishment of dominance in a teleost model of non-breeding aggression: neuropeptide-specific and status-dependent actions
Authors: Pouso Paula , Cabana Álvaro , Francia Virginia , Silva Ana
Published: January 2023

The establishment of the dominant-subordinate status implies a clear behavioral asymmetry between contenders that arises immediately after the resolution of the agonistic encounter and persists during the maintenance of stable dominance hierarchies. Changes in the activity of the brain social behavior network (SBN) are postulated to be responsible for the establishment and maintenance of the dominant-subordinate status. The hypothalamic nonapeptides of the vasopressin/vasotocin (AVP/AVT) and oxytocin/mesotocin/isotocin (OXT/MST/IT) family are known to modulate the activity of the SBN in a context-dependent manner across vertebrates, including status-dependent modulations. We searched for status-dependent asymmetries in AVT/IT cell number and activation immediately after the establishment of dominance in the weakly electric fish, Gymnotus omarorum, which displays the best understood example of non-breeding territorial aggression among teleosts. We used immunolabeling (FOS, AVT, and IT) of preoptic area (POA) neurons after careful designed intermale dyadic agonistic encounters. We show for the first time in teleosts, that AVT, but not IT, is involved in the establishment of the dominant-subordinate status. We also found status-dependent POA subregion-specific changes of AVT cell number and activation that confirm the involvement of AVT in the establishment of dominance likely achieved by the release of AVT from dominants’ AVT neurons.
On the Dotsenko-Fateev complex twin of the Selberg integral and its extensions
Authors: Neretin Yury
Published: January 2023

The complex Dotsenko-Fateev integral In(σ; τ ; θ) is the Selberg beta integral, where real variables in the integrand ∏|xk | σ-1 |1- xk | τ-1 ∏| xk-x1|2θ are replaced by complex variables and an integration over a cube is replaced by
an integration over the whole Cn. According Dotsenko, Fateev, and Aomoto, such integral is a product of Gamma functions. We dene a family of beta integrals over spaces Cm × Cm+1 × ...× Cn, which for m = n gives the integral In (with three additional integer parameters.
Systemic steroid therapy for pneumonic chronic obstructive pulmonary disease exacerbation: A retrospective cohort study
Authors: Shiroshita Akihiro , Anan Keisuke , Takeshita Masafumi , Kataoka Yuki
Published: January 2023

The effectiveness of systemic steroid therapy on mortality in patients with pneumonic chronic obstructive pulmonary disease (COPD) exacerbation is unclear. We evaluated the association between systemic steroid therapy and 30-day mortality after adjusting for known confounders, using data from the Health, Clinic, and Education Information Evaluation Institute in Japan, which longitudinally followed-up patients in the same hospital. We selected patients aged ≥ 40 years admitted for pneumonic chronic obstructive pulmonary disease (COPD) exacerbation. The exclusion criteria were censoring within 24 h, comorbidity with other respiratory diseases, and daily steroid use. Systemic steroid therapy was defined as oral/parenteral steroid therapy initiated within two days of admission. The primary outcome was the 30-day mortality. To account for known confounders, each patient was assigned an inverse probability of treatment weighting. The outcome was evaluated using logistic regression. Among 3,662 patients showing pneumonic COPD exacerbation, 30-day mortality in the steroid therapy and non-steroid therapy groups was 27.6% (169/612) and 21.9% (668/3,050), respectively. Systemic steroid therapy indicated a slightly higher estimated probability of 30-day mortality (difference in the estimated probabilities, 3.59%; 95% confidence interval: -0.36–7.54%). Systemic steroid therapy within two days of admission was associated with higher 30-day mortality rates in pneumonic COPD exacerbation.
Characteristics of Coronary Artery Ectasia and Accompanying Plaques: An Optical Coherence Tomography Study
Authors: yu huai , Dai jiannan , tang hao , fang chao , jiang senqing , tu yingfeng , yu bo
Published: January 2023

Objective
Coronary artery ectasia (CAE) in adults is often caused by atherosclerotic plaques. CAE can affect atherosclerotic plaques through hemodynamic changes. However, no study has evaluated the characteristics of CAE with atherosclerotic plaques. Therefore, we aimed to disclose the characteristics of atherosclerotic plaques in patients with CAE using optical coherence tomography (OCT).
Methods and results
We evaluated patients with CAE, confirmed by coronary angiography, who underwent pre-intervention OCT between April 2015 and April 2021. Each millimeter of the OCT images was analyzed to assess the characteristics of CAEs, plaque phenotypes, and plaque vulnerability. A total of 286 patients (344 coronary vessels) met our criteria, 82.87% of whom were men. Right coronary artery lesions were the most common, comprising 44.48% (n = 153) of the total. We found 329 CAE vessels with plaques, accounting for 95.64% of the coronary vessels. After grouping CAEs and plaques by their relative positions, we found that the length of plaques within CAE lesions was longer than that of plaques in other sites (P < 0.001). Plaques within CAE lesions had greater maximum lipid angles and lipid indexes (P = 0.007, P = 0.004, respectively) than those on other sites.
Conclusions
This study revealed the most common vascular and morphological characteristics of CAE. While the accompanying plaques were not affected by the location or morphology of the CAE vessels, they were affected by their position relative to the CAE lesion.
The Impact of Dominant Ventricular Morphology on the Early Postoperative Course after the Glenn Procedure
Authors: Keizman Eitan , Abarbanel Inbar , Salem Yishai , Mishaly David , Serraf Alain E. , Pollak Uri
Published: January 2023

The dominant ventricular morphology affects both the early and late outcomes of the Fontan procedure, but its impact on the patients’ status immediately following the Glenn procedure is unknown. This study aimed to evaluate the effect of the infants' dominant ventricular morphology on the immediate course after undergoing the Glenn procedure. This single-center, retrospective study included all patients who underwent the Glenn procedure between October 2003 and May 2016. The patients were divided into two groups according to their dominant ventricular morphology. Their postoperative records were reviewed and compared. Out of the 89 patients who underwent the Glenn procedure during the study period, 40 (44.9%) had dominant right ventricular morphology and 49 (55.1%) had left ventricular morphology. There were no significant group differences in baseline characteristics or operative data. The maximal postoperative vasoactive-inotropic score was significantly higher and the extent of ventricular dysfunction was significantly more severe in the dominant right ventricle group (P < 0.05). The length of hospitalization was slightly but not significantly longer in the hypoplastic LV group. It is concluded that a dominant LV morphology has superior ventricular function and requires less inotropic support compared to a dominant RV morphology in the immediate postoperative course following the Glenn procedure, although overall survival was not affected by these differences. Further study to determine the pathophysiologic basis for these differences is warranted.
Focused beam self-cleaning during laser filamentation
Authors: Pushkarev Dmitrii V. , Rizaev Georgy E. , Mokrousova Daria V. , Gavrilov Sergey Yu. , Levus Maximilian V. , Mitricheva Elizaveta S. , Seleznev Leonid V. , Ionin Andrey A.
Published: January 2023

The beam self-cleaning phenomenon is theoretically predicted by the two-dimensional nonlinear Schrödinger equation, which describes self-focusing, and is observed in the case of femtosecond laser filamentation in the collimated regime of propagation. However, the impact of external focusing on the self-cleaning has not been investigated so far. In this paper we systematically study this impact in a wide range of focusing conditions. We show that the energy range, in which self-cleaning can be observed, shrinks monotonically with the numerical aperture growth at some point vanishing at all.
Boundedness in a higher-dimensional singular chemotaxis-growth system with indirect signal production *
Authors: Liu Chao , Ren Guoqiang , Liu Bin
Published: January 2023

In this paper, we consider a higher-dimensional singular chemotaxis-growth system with indirect signal production. Under appropriate regularity assumption on the initial data, the global boundedness of classical solution is obtained. Our results improve and complement previously known ones.
Resolving the Transportation Problem with Hexagonal Intuitionistic Fuzzy Numbers
Authors: N karthikeyan , R Srinivasan , Mohammad Esmael Samei
Published: January 2023

Fuzzy numbers play crucial roles in topics relating to dynamics, information analysis, and economics strategy. A necessary advancement in many numerical models is finding the Positioning of many fuzzy numbers. The optimal result for the transportation problems was generated using a Fuzzy number of offered techniques. We alter the Hexagonal Intuitionistic Fuzzy transportation problem to a dazzling esteemed one in this paper’s proposed positioning strategy, which is then applied to another recommended interaction to find the Fuzzy reasonable arrangement. The statistical illustration demonstrates the new proposed method’s delicate and wonderful approaches to handling the transportation challenges based on fuzzy calculations.
(2010) Mathematics Subject Classifications: 34C10, 34K11, 34K40, 39A10.
The qualitative research on the experience of special education teachers for young children with the families of young children with special needs: focused on van Manen’s hermeneutic phenomenological study -
Authors:   Korean Journal Of Early Childhood Special Education, Lee Jung Yoon
Published: January 2023

The family is the most fundamental environment for the young children with special needs. The detailed insight on the experience of the special education teachers for young children and the family need to be conducted to reveal the significance of the relation and the collaboration between the special teacher for young children and the family. The purpose of this study were to investigate and to understand the special education teachers’ experience on the family of young children with special needs. The special education teachers for young children’ experience was inductively analyzed according to themes based on van Manen’s hermeneutic phenomenological study. The study participants were 11 special education teachers who had been taught in preschool. Data collection was conducted by the individual interview and the group interview with the teachers. As a results of analysis, 15 sub-themes and 6 essential themes were revealed. For educational practice, the forming a relationship process and the practical collaboration between the special education teachers and the family of young children with special needs were revealed through the study. Furthermore, theses results would be the valuable data for a consideration of the plan for strengthen the special education teachers for young children’ ability to collaborate and to form a good relationship with the family of the young children with special needs.
Rezension zu: Gregor Berghammer, Caracalla. Die Militärautokratie des Kaisers Severus Antoninus
Authors: Deeg Philipp
Published: January 2023

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Rezension zu: Kerstin Droß-Krüpe, Semiramis, de qua innumerabilia narrantur. Rezeption und Verargumentierung der Königin von Babylon von der Antike bis in die opera seria des Barock
Authors: Steffensen Nils
Published: January 2023

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Production of adsorbents based on sunflower husks for removal of chromium (VI) from wastewater
Authors: Fedotov A. A. , Rudenko E. Yu.
Published: January 2023

At present, industrial and agricultural waste is often used as sorption materials for water remediation. Adsorbents obtained from sunflower husks were used for wastewater treatment from chromium (VI) ions. Studies were carried out using unmodified and modified sunflower husk and a model wastewater solution containing 10 mg/dm3 of chromium (VI) ions. Solutions of acids (H2SO4, HNO3, HCl, H3PO4) and alkalis (KOH, NaOH) were used to modify sunflower husks. The maximum sorption capacity was revealed in sunflower husks treated with sulfuric acid; thus, this modifying agent only was used in further experiments. The modification was carried out using 1–4 M solutions of H2SO4 at 30–75 °C for 30–120 min. The research results showed that the acid treatment of sunflower husks is more effective than that using alkalis. The sorption capacity of the modified sunflower husk increased up to the concentration of sulfuric acid of 3 M, followed by a further decrease. A full factorial design having 3 factors of the experiment was set, which allowed the maximum sorption capacity to be identified. The optimal modification procedure was as follows: sunflower husks are treated using 2.5 M sulfuric acid solution at 60 °C for 30 min, washed with distilled water and dried at 105 °C to a constant weight. Studies showed that adsorbents obtained from sunflower husks can be used to remove chromium (VI) ions from wastewater.
Development of biotechnology for cheese having a noble mould: A relationship between biochemical processes and product quality
Authors: Sturova Yu. G. , Grishkova A. V. , Konshin V. V.
Published: January 2023

Since late 2014, following the embargo, a significant reduction in cheese import, including mould cheese, has been observed. Developing new cheese technologies comprise therefore an urgent task for the milk industry. The cheeses ripened using noble mould represent a wholesome product, rich in protein, which contains many essential amino acids, beneficial for strengthening the walls of blood vessels and reducing angiasthenia. The microorganisms in the cheese starter culture create favourable conditions for healthy microflora in the gastrointestinal tract, preventing fermentation and meteorism. The high content of vitamin B12 in these cheeses has a positive effect on the central nervous system. Any production must be economically viable, lowering the production costs. In order to increase income, and consequently the profitability of production, the method of cheese ripening using a noble mould, obtained from a mixture of whole milk and secondary protein-carbohydrate raw materials, was proposed. The influence of the type of protein-carbohydrate raw material, yeast and mould on the physicochemical and organoleptic properties of the product was investigated. The optimal ratio of raw materials (milk:buttermilk) for cheese production was determined. The relative composition of nitrogen fractions and the presence and amount of volatile fatty acids in the proposed product were also examined. It was shown that proteolysis and lipolysis processes were more intensive in the experimental cheeses produced using a noble mould, resulting in the improvement of organoleptic characteristics of the finished product. The resulting soft cheese having unique characteristics and a tangy mushroom flavour can be recommended for production in cheese factories.
Polymer-polymer composition of polyvinyl alcohol and polyhexamethylene guanidine hydrochloride for antimicrobial surface protection
Authors: Okladnikova V. O. , Ochirov O. S. , Grigor’eva M. N. , Stelmakh S. A.
Published: January 2023

Since 2020, surface disinfection has become particularly relevant thus requiring improved approaches to its implementation. Conventional disinfectants comprising concentrated solutions or soluble tablets fail to fully comply with the need for antimicrobial protection of surfaces, calling for their repetitive application. This leads to considerable expenses, with the price of disinfectants rising by 30–50% over the past two years. In this article, agents characterised by prolonged action due to film-forming antimicrobial components having good adhesion to various surfaces are developed in order to reduce the cost of the disinfection procedure and increase its efficiency. In addition, such systems can be used as additives to water paint coatings for minor maintenance of medical and preventive institutions. These materials can significantly reduce the growth rate of the harmful bacteria population, as well as provide long-term protection against it. In order to implement this approach, the polymer-polymer composition based on polyvinyl alcohol and polyhexamethylene guanidine hydrochloride was developed. It should be noted that guanidine-containing polymers are characterised by high antimicrobial activity and low human toxicity, being also widely used as active agents in disinfectants. An excellent film-forming polymer exhibiting good adhesive properties, polyvinyl alcohol is non-toxic and chemically inert. Thus, the use of such additives can significantly reduce the extension of harmful bacteria, especially in crowded public areas.