bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of a New Positive Allosteric Modulator of AMPA Receptors - PAM-43: Specific Binding of the Ligand and its Ability to Potentiate AMPAR Currents
Authors: Vyunova Tatiana V. , Andreeva Lioudmila A. , Shevchenko Konstantin V. , Grigoriev Vladimir V. , Palyulin Vladimir A. , Lavrov Mstislav I. , Bondarenko Ekaterina V. , Kalashnikova Elena E. , Myasoedov Nikolay F.
Published: March 2020

Background:

Currently, the most dynamic areas in the glutamate receptor system neurobiology
are the identification and development of positive allosteric modulators (PAMs) of glutamate
ionotropic receptors. PAM-based drugs are of great interest as promising candidates for the treatment of
neurological diseases, such as epilepsy, Alzheimer's disease, schizophrenia, etc. Understanding the
molecular mechanisms underlying the biological action of natural and synthetic PAMs is a key point for
modifying the original chemical compounds as well as for new drug design.

Objective:

We are trying to elaborate a system of molecular functional screening of ionotropic glutamate
receptor probable PAMs.

Methods:

The system will be based on the radioligand - receptor method of analysis and will allow
rapid quantification of new AMPAR probable PAMs molecular activity. We plan to use a tritiumlabeled
analogue of recently elaborated ionotropic GluR probable PAM ([3H]PAM-43) as the main
radioligand.

Results:

Here, we characterized the specific binding of the ligand and its ability to potentiate ionotropic
GluR currents. The existence of at least two different sites of [3H]PAM-43 specific binding has been
shown. One of the above sites is glutamate-dependent and is characterized by higher affinity. “Patchclamp”
technique showed the ability of PAM-43 to potentiate ionotropic GluR currents in rat cerebellar
Purkinje neurons in a concentration-dependent manner.

Conclusion:

The possibility of using PAM-43 as a model compound to study different allosteric effects
of potential regulatory drugs (AMPAR allosteric regulators) was shown. [3H]PAM-43 based screening
system will allow rapid selection of new AMPAR probable PAM structures and quantification of their
molecular activity.
A Conceptual Framework to Study the Implementation of Clinical Decision Support Systems (BEAR): Literature Review and Concept Mapping (Preprint)
Authors: Camacho Jhon , Zanoletti-Mannello Manuela , Landis-Lewis Zach , Kane-Gill Sandra L , Boyce Richard D
Published: March 2020

BACKGROUND

The implementation of clinical decision support systems (CDSSs) as an intervention to foster clinical practice change is affected by many factors. Key factors include those associated with behavioral change and those associated with technology acceptance. However, the literature regarding these subjects is fragmented and originates from two traditionally separate disciplines: implementation science and technology acceptance.

OBJECTIVE

Our objective is to propose an integrated framework that bridges the gap between the behavioral change and technology acceptance aspects of the implementation of CDSSs.

METHODS

We employed an iterative process to map constructs from four contributing frameworks—the Theoretical Domains Framework (TDF); the Consolidated Framework for Implementation Research (CFIR); the Human, Organization, and Technology-fit framework (HOT-fit); and the Unified Theory of Acceptance and Use of Technology (UTAUT)—and the findings of 10 literature reviews, identified through a systematic review of reviews approach.

RESULTS

The resulting framework comprises 22 domains: agreement with the decision algorithm; attitudes; behavioral regulation; beliefs about capabilities; beliefs about consequences; contingencies; demographic characteristics; effort expectancy; emotions; environmental context and resources; goals; intentions; intervention characteristics; knowledge; memory, attention, and decision processes; patient–health professional relationship; patient’s preferences; performance expectancy; role and identity; skills, ability, and competence; social influences; and system quality. We demonstrate the use of the framework providing examples from two research projects.

CONCLUSIONS

We proposed BEAR (BEhavior and Acceptance fRamework), an integrated framework that bridges the gap between behavioral change and technology acceptance, thereby widening the view established by current models.
Two Decades of Research Using Taiwan’s National Health Insurance Claims Data: Bibliometric and Text Mining Analysis on PubMed (Preprint)
Authors: Sung Sheng-Feng , Hsieh Cheng-Yang , Hu Ya-Han
Published: March 2020

BACKGROUND

Studies using Taiwan’s National Health Insurance (NHI) claims data have expanded rapidly both in quantity and quality during the first decade following the first study published in 2000. However, some of these studies were criticized for being merely data-dredging studies rather than hypothesis-driven. In addition, the use of claims data without the explicit authorization from individual patients has incurred litigation.

OBJECTIVE

This study aimed to investigate whether the research output during the second decade after the release of the NHI claims database continues growing, to explore how the emergence of open access mega journals (OAMJs) and lawsuit against the use of this database affect the research topics and publication volume and to discuss the underlying reasons.

METHODS

PubMed was used to locate publications based on NHI claims data between 1996 and 2017. Concept extraction using MetaMap was employed to mine research topics from article titles. Research trends were analyzed from various aspects, including publication amount, journals, research topics and types, and cooperation between authors.

RESULTS

A total of 4473 articles were identified. A rapid growth in publications was witnessed from 2000 to 2015, followed by a plateau. Diabetes, stroke, and dementia were the top 3 most popular research topics whereas statin therapy, metformin, and Chinese herbal medicine were the most investigated interventions. Approximately one-third of the articles were published in open access journals. Studies with two or more medical conditions, but without any intervention, were the most common study type. Studies of this type tended to be contributed by prolific authors and published in OAMJs.

CONCLUSIONS

The growth in publication volume during the second decade after the release of the NHI claims database was different from that during the first decade. OAMJs appeared to provide fertile soil for the rapid growth of research based on NHI claims data, in particular for those studies with two or medical conditions in the article title. A halt in the growth of publication volume was observed after the use of NHI claims data for research purposes had been restricted in response to legal controversy. More efforts are needed to improve the impact of knowledge gained from NHI claims data on medical decisions and policy making.
Innovation in Pain Rehabilitation Using Co-Design Methods During the Development of a Relapse Prevention Intervention: Case Study (Preprint)
Authors: Elbers Stefan , van Gessel Christa , Renes Reint Jan , van der Lugt Remko , Wittink Harriët , Hermsen Sander
Published: March 2020

BACKGROUND

Many intervention development projects fail to bridge the gap from basic research to clinical practice. Instead of theory-based approaches to intervention development, co-design prioritizes the end users’ perspective as well as continuous collaboration between stakeholders, designers, and researchers throughout the project. This alternative approach to the development of interventions is expected to promote the adaptation to existing treatment activities and to be responsive to the requirements of end users.

OBJECTIVE

The first objective was to provide an overview of all activities that were employed during the course of a research project to develop a relapse prevention intervention for interdisciplinary pain treatment programs. The second objective was to examine how co-design may contribute to stakeholder involvement, generation of relevant insights and ideas, and incorporation of stakeholder input into the intervention design.

METHODS

We performed an embedded single case study and used the double diamond model to describe the process of intervention development. Using all available data sources, we also performed deductive content analysis to reflect on this process.

RESULTS

By critically reviewing the value and function of a co-design project with respect to idea generation, stakeholder involvement, and incorporation of stakeholder input into the intervention design, we demonstrated how co-design shaped the transition from ideas, via concepts, to a prototype for a relapse prevention intervention.

CONCLUSIONS

Structural use of co-design throughout the project resulted in many different participating stakeholders and stimulating design activities. As a consequence, the majority of the components of the final prototype can be traced back to the information that stakeholders provided during the project. Although this illustrates how co-design facilitates the integration of contextual information into the intervention design, further experimental testing is required to evaluate to what extent this approach ultimately leads to improved usability as well as patient outcomes in the context of clinical practice.
Defining Patient-Oriented Natural Language Processing: A New Paradigm for Research and Development to Facilitate Adoption and Use by Medical Experts (Preprint)
Authors: Sarker Abeed , Al-Garadi Mohammed Ali , Yang Yuan-Chi , Choi Jinho , Quyyumi Arshed A , Martin Greg S
Published: March 2020

UNSTRUCTURED

The capabilities of natural language processing (NLP) methods have expanded significantly in recent years, and progress has been particularly driven by advances in data science and machine learning. However, NLP is still largely underused in patient-oriented clinical research and care (POCRC). A key reason behind this is that clinical NLP methods are typically developed, optimized, and evaluated with narrowly focused data sets and tasks (eg, those for the detection of specific symptoms in free texts). Such research and development (R&D) approaches may be described as problem oriented, and the developed systems perform specialized tasks well. As standalone systems, however, they generally do not comprehensively meet the needs of POCRC. Thus, there is often a gap between the capabilities of clinical NLP methods and the needs of patient-facing medical experts. We believe that to increase the practical use of biomedical NLP, future R&D efforts need to be broadened to a new research paradigm—one that explicitly incorporates characteristics that are crucial for POCRC. We present our viewpoint about 4 such interrelated characteristics that can increase NLP systems’ suitability for POCRC (3 that represent NLP system properties and 1 associated with the R&D process)—(1) interpretability (the ability to explain system decisions), (2) patient centeredness (the capability to characterize diverse patients), (3) customizability (the flexibility for adapting to distinct settings, problems, and cohorts), and (4) multitask evaluation (the validation of system performance based on multiple tasks involving heterogeneous data sets). By using the NLP task of clinical concept detection as an example, we detail these characteristics and discuss how they may result in the increased uptake of NLP systems for POCRC.
Comparing UpToDate and DynaMed Plus as medical knowledge resources for clinical decision support: cross-over randomized trial (Preprint)
Authors: Baxter Sally L , Lander Lina , Clay Brian , Bell John , Hansen Kristen , Walker Amanda , Tai-Seale Ming
Published: March 2020

BACKGROUND

Electronic medical knowledge resources are frequently used for clinical decision support. Costs vary substantially among vendors, warranting periodic assessment of institution-wide adoption.

OBJECTIVE

To compare two medical knowledge resources, UpToDate and DynaMed Plus, with respect to facilitating accuracy and efficiency of answering standardized clinical questions and user experience.

METHODS

Physicians in training at a single academic medical center were randomized to first use one of the two medical knowledge resources to answer six standardized clinical case questions. They were surveyed about their experience using the resource, then completed the questions using the other resource, followed by the user experience survey again. The percentage of accurate answers and time required to answer each question were recorded. The surveys assessed ease of use, enjoyment using the resource, quality of information, and ability to assess the level of evidence. Given the cross-over design, tests of carry-over effects were performed. For open-ended survey items regarding overall user experience, themes were identified, and sentiment analyses were performed.

RESULTS

Twenty-six physicians in training participated, with a mean (standard deviation, SD) of 5.8 (2.5) years of prior experience using UpToDate. Accuracy of answers when using the two resources generally differed by 4 percentage points or less. For all but one question, there were no significant differences in the time required for completion. Most participants perceived both resources to be easy to use, have high quality of information, and felt able to assess to the level of evidence contained in the information. A greater proportion of participants (23/26, 88%) endorsed enjoyment of use when using UpToDate compared to when using DynaMed Plus (16/26, 62%). Participants were significantly less likely to enjoy DynaMed Plus if they were in the randomization group assigned to use UpToDate first (p=0.006). Themes emerging from open-ended survey comments included interface/information presentation, coverage of clinical topics, search functions, and utility for clinical decision-making. Overall, the majority (59%) of open-ended comments expressed an overall preference for UpToDate, while only 19% expressed an overall preference for DynaMed Plus.

CONCLUSIONS

DynaMed Plus is non-inferior to UpToDate with respect to ability to achieve accurate answers, time required for answering clinical questions, ease of use, quality of information, and ability to asses level of evidence. However, user experience was more positive with UpToDate, leading to a majority of users stating a preference for UpToDate. Future studies of electronic medical knowledge resources should continue to emphasize evaluation of usability and user experience.
Acceptability and Satiety Evaluation of a Newly Developed Nutritionally Balanced School Meal
Authors: Ali Manal Abdeen , Mahmoud Ibtihag Awad , Balla Sawsan Ahmed , Lecomte Rekha , Dehondt Laura , Abdekareem Eman Ahmed , Gubara AbdelHalim Rahma
Published: March 2020

Five nutritious school meals were developed in a form of pastes based on leguminous seeds of Lentil, Chick pea, and Soya; and some dairy sources, all formulas contain groundnut, but few in crushed formed are used to test acceptance. The products were fortified with essential minerals and vitamins. Developed products were served as a breakfast meal to ~200 students (6-9 years juniors; 10-14 years seniors) in one of the Sudanese school where school feeding is in place (Omdurman City) for 21 days to substitute a traditional breakfast meal based on boiled Pigeon pea colloquially called “Balila” served routinely to the students. This paper covers acceptability of novel favorable products behavioral responses of senior and junior students to four meal/ subject interactions covering temptation to finishing the whole meal, reason(s) for not finishing the whole meal, time needed to finish the meal, and degree of satiety the students feel during class room hours.Almost 95% of the senior students interacted positively with pastes based on lentil or chick pea finishing or stop taking the meal in ? 10 minutes. All past products provide satiety; senior students judged on lentil based paste(s) as the meal that secures full satiety during school hours. Unlike seniors, more than 95% of junior students finished more of the soy based meal, one third of them took more time to finish lentil based meal, yet reflected satisfaction by taking less quantities from all products offered.. Degree of satiety feeling among junior students fluctuated where >90% of them showed satisfactory degree of satiety with all products offered.
Nuestras perlas escondidas
Authors: Rossanda Rossana
Published: March 2020

Nuestras perlas escondidas
Más que hombres, mujeres
Authors: Milán Colectivo , Kuoni Simone , Malagón Sofía
Published: March 2020

Más que hombres, mujeres
El encuentro con el feminismo
Authors: Rossanda Rossana , Huerta David
Published: March 2020

El encuentro con el feminismo
Hacia una teoría de las transacciones desiguales: aportaciones de las discusiones antropológicas y sociológicas al debate feminista
Authors: M. Rosas Ana
Published: March 2020

Hacia una teoría de las transacciones desiguales: aportaciones de las discusiones antropológicas y sociológicas al debate feminista
Ni tanto ni tan poco: las reformas penales relativas a la violencia sexual
Authors: De Barbieri Teresita , Cano Gabriela
Published: March 2020

Ni tanto ni tan poco: las reformas penales relativas a la violencia sexual
Si nos da igual (Opus 105)
Authors: Felipe Liliana
Published: March 2020

Si nos da igual (Opus 105)
Clínicas jurídicas a la luz del Estado Social de Derecho y de Justicia Venezolano
Authors: Ferrer de Rivas Lesbia Mercedes
Published: March 2020

El presente artículo persigue interpretar el rol que desempeña las Clínicas Jurídicas a la luz del estado social de derecho y de justicia. Se hace necesario plantear además la importancia que desde la experiencia educativa, se participe y promueva la revisión de los currículos de la carrera de Derecho en las diferentes universidades del país, con la finalidad que se asuma el reto de lograr desde las aulas universitarias un profesional comprometido con los postulados constitucionales, servidor con sentido de responsabilidad social, pertinencia y ética profesional en las diferentes disciplinas del derecho, y, que más allá de los claustros universitarios el futuro abogado logre poner en práctica sus conocimientos, que le aseguren su desarrollo personal, ético y profesional en el ámbito de sus competencias. En tal virtud, se hace imperioso resignificar las clínicas jurídicas bajo los postulados Constitucionales, como una herramienta pedagógica integral en la formación prospectiva del abogado Venezolano.
La protección jurídica de la mujer en casos de violencia sexual al hilo del conflicto en la republica democrática del Congo
Authors: Díaz Galán Elena Carolina
Published: March 2020

La situación en la República Democrática del Congo es de permanente conflicto. Ello supone que se produzcan graves violaciones de los derechos humanos, en particular, en los grupos más vulnerables entre los que se encuentran las mujeres. Además, los comportamientos de violencia sexual son bastantes habituales. El Derecho internacional ofrece soluciones normativas a estas cuestiones a través del Derecho Internacional humanitario y las reglas relativas a la protección de los derechos humanos. Sin embargo, en el conflicto en este país africano se produce una falta de eficacia de estas normas. El Estado congoleño no garantiza, por su fragilidad e inestabilidad, que no se produzca la violencia sexual y, asimismo,la Misiónde Naciones Unidas, aunque colabora en la disminución de las violaciones, tampoco ha sido capaz de poner término a estos comportamientos especialmente ilícitos.
Los Derechos Humanos en la jurisdicción española
Authors: Carrillo Marc
Published: March 2020

La posición de los derechos humanos en la jurisdicción española está integrada en el sistema europeo del constitucionalismo multinivel. La jurisdicción ordinaria es la sede habitual de protección de los derechos mientras que es una garantía excepcional. La regla interpretativa del margen de apreciación nacional que caracteriza a la justicia convencional de la Corte Europea de Derechos Humanos no  puede ser utilizada para evitar los casos conflictivos. Por otra parte, el uso habitual procedimiento de la cuestión prejudicial ante el Tribunal de Luxemburgo ha provocado la descentralización del sistema de garantías de los derechos humamos en Europa. 
Liminar
Authors: Fernández Ruiz Jorge
Published: March 2020

Se realiza una presentación del número 276 de la Revista de la Facultad de Derecho de México, donde se describe brevemente el contenido del número en cuestión.
IMPLEMENTASI PEMBELAJARAN DAN PENILAIAN HOTS PADA SISWA KELAS 4 SEKOLAH INDONESIA BANGKOK THAILAND
Authors: Yayuk Erna , Deviana Tyas , Sulistyani Nawang
Published: March 2020

ABSTRAK Implementasi kurikulum 2013 menuntut guru untuk melakukan penilaian  HOTS. Pada dasarnya penilaian HOTS harus diawali dengan pembelajaran yang HOTS juga. Hasil yang didapatkan berdasarkan pengamatan di SIB Thailand bawasannya masih ditemukan adanya (1) beberapa guru yang masih memerlukan updating tentang pengetahuan terutama kurikulum 2013, (2) kurang lebih 45% siswa masih pasif ketika diajar dan keaktifan kelas sering didominasi oleh anak-anak yang pintar. (3) dalam proses pembelajaran soal-soal yang dibuat guru kebanyakan masih pada level C1-C3, dan (4) kemampuan siswa dalam berfikir kritis dan analitis sangat kurang. Berdasarkan analisis masalah tersebut, tujuan penelitian ini untuk meningkatkan kemampuan guru-guru terhadap pembelajaran dan penilaian HOTS. Metode penelitian yang digunakan yaitu penelitian kualitatif. Adapun hasil yang didapatkan meliputi (a) hasil contoh perangkat pembelajaran dan penilaian HOTS yang meliputi RPP, (b) Lembar Kegiatan Siswa (LKS), (c) evaluasi pembelajaran, (d) instrumen penilaian HOTS, dan (e) video pembelajaran dan penilaian HOTS. Kata kunci: Pembelajaran, Penilaian, HOTS ABSTRACTThe implementation of the 2013 curriculum requires teachers to conduct HOTS assessments. Basically the HOTS assessment must begin with HOTS learning as well. The results obtained based on observations at SIB Thailand are still found in (1) some teachers who still need updating of knowledge, especially the 2013 curriculum, (2) approximately 45% of students are still passive when taught and class activeness is often dominated by smart children. (3) in the learning process the questions made by the teacher are mostly still at levels C1-C3, and (4) the ability of students in critical and analytical thinking is very lacking. Based on the analysis of the problem, the purpose of this study was to improve the ability of teachers to learn and assess HOTS. The research method used is qualitative research. The results obtained include (a) the results of examples of HOTS learning and assessment devices which include lesson plans, (b) Student Activity Sheets (LKS), (c) learning evaluation, (d) HOTS assessment instruments, and (e) videos learning and assessment HOTS. Key words: Learning, Assessment, HOTS
PERANCANGAN TRAINER MIKROKONTROLER SEBAGAI MEDIA PEMBELAJARAN UNTUK MENINGKATKAN NILAI PEREKAYASAAN SISTEM KONTROL PADA SMK
Authors: Suryania Febriana , Sukardjo Moch. , Yusro M.
Published: March 2020

Penelitian menggunakan R&D dengan metode ADDIE dan Borg & Gall sebagai penelitian pendahuluan. Penelitian dilakukan di SMK Teknik Elektronika Industri, dengan jumlah responden 31 siswa yang akan mengambil mata pelajaran perekayasaan sistem kontrol. Penelitian ini merancang trainer mikrokontroler sebagai media pembelajaran pada kurikulum 2013 dengan melihat nilai kognitif dan psikomotor sebagai hasil peningkatan siswa. Penelitian ini dibuat karena perubahan kurikulum yang berdampak pada perubahan mata pelajaran praktikum yang mengakibatkan kebutuhan akan prasarana sebagai penunjang belajar praktikum. Penilaian  menggunakan tes pilihan ganda yang sudah divalidasi terlebih dahulu dan kemudian diujikan kepada siswa dengan membandingkan antara nilai pretest dan posttest. Kemudian, penelitian ini menggunakan uji-t sebagai perhitungan dalam mengetahui tingkat efektifitas belajar baik secara kognitif maupun psikomotor.Kata kunci: ADDIE, Trainer Mikrokontroler, psikomotorik, efektifitas
Studi Toksisitas: Ekstrak Metanol Bonggol Pisang Ambon (Musa acuminata L. cv. Gros Michel) terhadap Aedes aegypti (Diptera: Culcidae)
Authors: Komala Siskha Noor , Budianto Bambang Heru , Basuki Edi
Published: March 2020

Aedes aegypti mosquito is the main vector of dengue virus causing dengue hemorrhagic fever (DHF) in Indonesia. The main preventive action is to control the presence of Ae. aegypti mosquito. Banana plants are known to contain secondary metabolite compounds acting as a natural insecticide, including the hump part. This research was conducted to evaluate to toxicity of hump of Ambon banana extract (Musa acuminata L. cv. Gros Michel) to dengue vector Ae. aegypti mosquito. The research used experimental method, the treatment concentration was 0.001; 0.01; 0.1; 1; 10; 100 and 1000 ppm of Ambon banana methanol extract and 0 ppm concentration as a control, each with three replications. The variables observed were individual deaths at every stage of development and morphological damage. The data obtained were analyzed using the analysis of variety and Duncan test with 95% confidence level. In addition, probit analysis was used to determine the value of LC50. The results showed that the study of toxicity indicates that in the further stage of development, the toxicity of methanol extract from Ambon banana hump was less toxic. Toxicity of Ambon banana hump methanol extract was highest in egg with LC50 value of 314,852 ppm. The methanol extract of banana Ambon has the morphological destructive activity in all development stages of Ae. aegypti.
THE ROLE OF CONSTRUCTIVISM-BASED LEARNING IN IMPROVING MATHEMATICAL HIGH ORDER THINKING SKILLS OF INDONESIAN STUDENTS
Authors: Minarni Ani , Napitupulu E. Elvis
Published: March 2020

To make students actively involved in learning to grasp mathematical higher-order thinking skills (MHOTS) is not easy. Meanwhile, the ability is so important for students to master for it takes place when students continue their studies to a higher level or work within a variety of professions, especially in the era of industrial revolution such nowadays. Many factors affect students' thinking abilities, including learning factor. This study, which implemented constructivism-based learning, aims to investigate the role and contribution of constructivism-based learning approaches as well as mathematical prior knowledge (MPK) to the achievement of MHOTS of middle secondary school students. The data tested through Multivariate Analysis at the 0.05 significance level. In general, this study found that: (1) In the experimental class, learning approach plays an important role in the way it increased students' MHOTS significantly. (2) The average contribution of constructivism-based learning to MHOTS was at the range 18% to 57%. (3) Student activity in learning increased significantly. (4) In some cases, there is an effect of interaction between learning factors and MPK towards the achievement of MHOTS. The study recommended the teachers to have courageous to implement constructivism-based teaching learning in order to improve students’ MHOTS.
Pengaruh Financial Leverage Terhadap Perataan Laba Dimoderasi Firm Size Di Perbankan Indonesia
Authors: Devi Heidy Paramitha
Published: March 2020

One of the steps that can be taken to reduce earnings fluctuations is income smoothing, by moving high income in a certain year into an unfavorable period, this is done to create a stable company profit so that it is reflected in good company performance in the eyes of investors. The purpose of this study is to determine whether company size is able to moderate the effect of financial leverage on income smoothing. This research was conducted at companies listed in the 2013-2017 banking period. The number of samples in this study were 110 samples that were selected using the purposive sampling method. The data analysis technique used in this study is logistic regression analysis. The results of this study indicate that financial leverage has no effect on income smoothing, and company size is not able to moderate the effect of financial leverage on income smoothing.
Keywords: Income Smoothing, Financial leverage, Company Size, Banking Sector
 JEL Classification:G21, G32, L25, M41
Richard Bassett, For God and Kaiser. The Imperial Austrian Army (New Haven; London: Yale University Press, 2016), 591 str.
Authors: Katanić Filip
Published: March 2020

Prikaz knjige
Upper limb robotic neurorehabilitation after pediatric stroke
Authors: Colovic Hristina , Dimitrijevic Lidija , Djuric Vanja , Jankovic Sonja
Published: March 2020

Introduction. Pediatric brain stroke is a rare condition, with the incidence of 1.2?13/100,000. The most common consequence is hemiparesis with unilateral hand impairment. There is level 4 evidence that robotics may improve the function of upper limbs. In this paper, we present the effect of combined robotic rehabilitation and kinesitherapy on the distal portion of the arm in the chronic phase of hemiparesis in childhood. Case outline. In a 7.5-year-old girl the treatment with robotic neurorehabilitation was administered in the chronic phase of post-stroke rehabilitation, 18 months after the stroke, involving individualized kinesitherapy for 30 minutes, and virtual reality-based rehabilitation using the robotic Smart Glove for 30 minutes. The rehabilitation protocol was administered for 12 weeks (five times a week). The results of therapeutic evaluation showed that the level 2 of Manual Ability Classification System remained unchanged until the end of treatment, while the grade assigned for the spasticity of flexors in the forearm and fingers was 2 at the treatment onset, 1+ after four weeks of therapy, and 1 after eight and 12 weeks of therapy. Qualitative improvement of arm function through the increase of the overall value of the Quality of Upper Extremity Skills Test was evidenced at each evaluation testing, being the greatest after the first four weeks of rehabilitation (4.83%). Conclusion. The result of our study suggests that combined robotic rehabilitation and kinesitherapy can improve the functional motor performance of the arm involved in the chronic recovery phase after a pediatric stroke.
Numerical investigation of the performance of perforated baffles in a plate-fin heat exchanger
Authors: Ameur Houari , Sahel Djamel , Menni Younes
Published: March 2020

The present paper is a numerical investigation on the performance of perforated baffles in a plate-fin heat exchanger. Two types of perforations are studied, namely the circular and elliptical shapes. Values of heat transfer coefficient, pressure drop, and thermal performance factor are determined for both cases and compared with those for a smooth channel. Also, the flow fields and heat transfer characteristics are determined for different fluids and various Reynolds numbers. The working fluids are complex, non-Newtonian and have an inelastic shear thinning behavior. The obtained results showed a good enhancement in the thermal performance factor by the suggested design in baffles. In the case of low viscous fluids, the elliptical perforated baffle performs better (by about 63.4%) than the circular one for all values of Reynolds number. But for highly viscous fluids, the elliptical perforation shows higher thermal performance than the circular hole by about 25% for low Reynolds numbers and 27% for high Reynolds numbers. The overall thermal performance factors are about 1.55 and 1.74 for the circular and elliptical perforations, respectively.
A numerical study on condensation heat transfer and pressure drop characteristics of low pressure vapor in a plate heat exchanger
Authors: Zhang Zhongbin , Zhang Tianyu , Zhang Hao
Published: March 2020

In this work, the condensation heat transfer and pressure drop characteristics of plate heat exchangers were simulated, and the 3-D temperature, pressure, and velocity fields were obtained. From the flow field, we can see that the velocity of vapor is higher than that of condensate. From the pressure field, we can see that the pressure shows a downward trend along the flow direction, and there is, the more pressure drop in the first half of the plate. From the temperature field, we can see that the temperature gradient increases with the increase of velocity and pressure gradient. Meanwhile, the effect of vapor mass-flow, dryness and super-heat on condensation heat transfer coefficients and pressure drops were investigated. The results show that the pressure drop and heat transfer coefficient both increase with the increase of dryness, degree of superheat and mass-flow. In addition, the correlation equations developed to predict the condensation heat transfer and friction factor perfectly agree with the experimental results.
Ranking energy performance opportunities obtained with energy audit in dairies
Authors: Josijevic Mladen , Sustersic Vanja , Gordic Dusan
Published: March 2020

The food industry uses a considerable amount of energy and that amount has been constantly growing with further developments in the sector. The growth of the milk processing industries with the production of dairy products has followed the trends in the food industry in general. The authors made a systematization of the literature data on the most common energy efficiency opportunities (measures) in diaries. Authors also present a methodology for conducting an energy audit in dairies based on ISO 50002 which includes a multi-criteria analysis for ranking energy efficiency opportunities. The proposed methodology was applied to a case study dairy in central Serbia. Taking into account interactions between opportunities, implementation of the proposed energy saving opportunities can ensure 11-15% energy savings for electricity and 20-23% of heat energy annually.
Determination of cop maximum of cold water loop of heat pump heating system by means of numerical-graphical optimization procedure
Authors: Pek Zoltan , Nyers Arpad , Nyers Jozsef
Published: March 2020

The paper presents the energy optimization of the cold water loop of the heat pump heating system using analytical-numerical procedure. The aim of the study is obtain the maximum COP of the heating system by optimum of the wall water mass-flow rate and well pump power. The objective function is the heating system?s COP. All components of the heating system: evaporator, condenser, compressor, circulation pump, and well pump are described by steady-state, lumped mathematical model. The model?s equations are coupled, non-linear, multivariable and algebraic, the solution is feasible using an iterative numerical method. The MATLAB?s program with Gauss elimination and Newton-linearization method is applied for solving the model. The obtained numerical data are presented in 3-D graphics. The optimum value of the cold-well water mass-flow rate is obtained from the graphics or by using a selection algorithm. The results of the study are the adequate mathematical model for energy optimization of the heating system, the numerical algorithm for solving the model and the ultimate goal to obtain the optimum of the power of well pump and compressor.
Improving Self-Care Management in Low-Income Latinos With Type 2 Diabetes Using Peer-Led U.S. Conversation Maps: A Quality Improvement Project in a Free Clinic
Authors: Fallas Carla R. , Pereira Katherine , Padilla Blanca Iris , Felsman Irene , Allen Sharon , Preik Curtis
Published: March 2020

A culturally sensitive Healthy Interactions Conversations Maps program was implemented for teaching diabetes self-management education (DSME) to Latinos with type 2 diabetes using peer-led educators in a community health center. Patients were invited to participate in a group care setting to improve access to providers and DSME. Goals were to improve diabetes distress, self-efficacy, and glycemic control as measured by A1C. Significant improvements were found for mean diabetes self-efficacy scores from before (2.53 ± 0.59) to after (2.91 ± 0.50) DSME (P <0.001). Mean A1C decreased significantly from before (9.51 ± 1.72%) to after (8.79 ± 1.68%) DSME (P = 0.043) at the end of the 6-month intervention. Thus, this program was found to be a useful tool for providing DSME in community health clinics serving low-income Latinos.
Studi Evaluatif Penerapan Strategi Pembelajaran Sosiologi di SMA N 2 Pariaman
Authors: Susanti Fetri Demi , Junaidi Junaidi
Published: March 2020

Pembelajaran sosiologi masing-masing kelas menuntut strategi pembelajaran yang berbeda namun guru yang mengajar tidak berbeda. Penelitian ini bertujuan untuk mengevaluasi strategi pembelajaran sosiologi oleh guru di SMAN 2 Pariaman, Metode penelitian yang digunakan adalah kualitatif tipe evaluatif. Hasil penelitian menggungkapkan bahwa strategi pembelajaran sosiologi yang diterapakan oleh guru di SMAN 2 Pariaman adalah strategi pembelajaran inquiri based learning dan problem solving based learning. Secara keseluruhan pelaksanaan strategi pembelajaran tersebut dilakukan guru berbeda dengan strategi yang terdapat di dalam RPP, ketidaksesuaian ini disebabkan karena kurangnya pemahaman guru mengenai strategi pembelajaran, kurangnya ketersediaan sumber belajar, kurangnya motivasi belajar siswa dan alokasi waktu. Sehingga hal tersebut mempengaruhi hasil belajar siswa. Hasil penelitian ini berguna sebagai pedoman dan masukan khususnya untuk guru mata pelajaran sosiologi dalam menerapkan strategi pembelajaran yang sesuai agar tujuan pembelajaran dapat dicapai secara optimal.
Pengaruh pemberian zat retardan terhadap pertumbuhan dan hasil ubi pada dua kultivar kentang (Solanum tuberosum L.) di dataran medium
Authors: Sumadi Sumadi , Suminar Erni , Murgayanti Murgayanti , Nuraini Anne
Published: March 2020

Tujuan dari kegiatan penelitian ini adalah untuk mendapatkan informasi mengenai kulti-var kentang dan jenis serta konsentrasi zat retardan yang dapat mendukung pertumbuhan dan perkembangan serta kuantitas dan kualitas hasil ubi bibit kentang di dataran medium. Metode penelitian yang digunakan adalah Rancangan Petak terpisah. Perlakuan terdiri dari petak utama yaitu kultivar yaitu kultivar Nadia dan Granola, dan anak petak yaitu jenis dan konsentrasi zat retardan dengan penggunaan paklobutrazol ( 0; 40; 120 mg L-1 ) atau coumarin (45; 90; 135 mg L-1). Hasil percobaan menun-jukkan bahwa jenis kultivar dan zat retardan berpengaruh terhadap pertumbuhan dan per-kembangan bibit kentang. Terjadi interaksi pada peubah bobot ubi per tanaman, sedangkan peubah tinggi tanaman, kandungan klorofil, jumlah ubi per tanaman, bobot ubi per petak dan persentase jumlah ubi kentang per tanaman berdasarkan pengkelasan ubi bibit tidak terjadi interaksi antara kultivar dan zat retardan.  Penggunaan zat retardan pada kultivar Nadia menghasilkan bobot ubi per tanaman lebih tinggi daripada kultivar Granola sedangkan untuk kelas ubi ukuran S dan M dihasilkan lebih tinggi pada kultivar Granola daripada kultivar Nadia. Kata kunci : Kentang ∙ Ubi ∙ Dataran medium ∙ Zat retardan
Respon tanaman mawar batik (Rosa hybrida L.) dengan penggunaan konsentrasi 1–methylcyclopropene (1–MCP) pada beberapa tingkat kemekaran bunga
Authors: Suradinata Yayat Rochayat , Wulansari A.
Published: March 2020

Mawar batik sebagai tanaman hias pot yang berkualitas baik memiliki tajuk yang proposional, ukuran bunga yang seragam dan memiliki kesegaran bunga yang lama, sehingga bunga mawar dapat dinikmati keindahannya lebih lama. Percobaan ini bertujuan untuk memperoleh kombinasi kemekaran bunga dan konsentrasi 1 – Methylcyclopropene (1-MCP) terhadap pertum-buhan dan kualitas  bunga pada tanaman mawar batik. Percobaan dilaksanakan sejak Januari 2014 hingga Februari 2014 di greenhouse yang berada di Desa Cihideung, Kabupaten Bandung Barat. Percobaan menggunakan Rancangan Petak Terbagi dengan dua factor, yaitu kemekaran bunga dan dosis 1-MCP, diulang sebanyak tiga kali. Kemekaran bunga yang digunakan yaitu kemekaran 0-10 %, kemekaran 10-25 %, kemekaran 50-75 % dan kemekaran 100 %. Konsentrasi 1-MCP yang diaplikasikan yaitu, 0 μl l-1 1-MCP, 0,25 μl l-1 1-MCP, 0,5 μl l-1 1-MCP, 0,75 μl l-1 1-MCP dan 1 μl l-1 1-MCP. Perbedaan antar perlakuan diuji dengan menggunakan uji F, sedangkan menguji perbedaan rata-rata perlakuan digunakan Uji Jarak Berganda Duncan pada taraf nyata 5 %. Hasil percobaan menunjukan bahwa kemekaran bunga dan konsentrasi 1-MCP berpengaruh terhadap komponen kualitas bunga yaitu, pertambahan diameter bunga dan lama kesegaran bunga, tapi tidak berpengaruh terhadap diameter bunga mekar. Sedangkan pada komponen pertumbuhan berupa pertambahan tinggi, pertambahan jumlah cabang, pertambahan diameter batang dan pertambahan daun per tanaman, pada berbagai perlakuan tidak berpengaruh nyata. Kombinasi perlakuan a1m3 (kemekaran 0-10 %, dosis 0,5 μl l-1) dan a3m2 (kemekaran 50-75 %, dosis 0,25 μl l-1) memberikan pengaruh lebih baik terhadap parameter lama kesegaran bunga dengan nilai masing-masing 9,83 hari dan 9,72 hari. Kombinasi perlakuan a1m2 (kemekaran 0-10 %, dosis 0,25 μl l-1) dan a3m2 (kemekaran 50-75 %, dosis 0,25 μl l-1) memiliki nilai yang lebih kecil dari perlakuan lain dengan nilai masing-masing 0,67 dan 0,61 cm pada parameter pertambahan diameter bunga. Kata kunci : 1 – Methylcyclopropene ∙ Kualitas bunga ∙ Mawar batik
APLIKASI PUPUK ORGANIK CAIR PADA TANAMAN KENTANG VARIETAS GRANOLA DI DATARAN MEDIUM
Authors: Karamina Hidayati , Fikrinda Wahyu
Published: March 2020

Kentang merupakan tanaman semusim dengan berbentuk menyemak dan memiliki sifat menjalar. Salah satu alternative upaya untuk meningkatkan hasil produktivitas kentang yaitu adalah penanaman kentang pada dataran medium. Tujuan dari penelitian ini adalah untuk menentukan jenis jenis dan takaran pupuk organik cair yang optimum dalam meningkatkan produksi kentang di dataran medium sehingga dari efektivitas itulah diharapkan pertumbuhan dan produktivitas kentang mampu optimal. Penelitian ini menggunakan Rancangan Acak Kelompok dengan 3 ulangan dengan 11 perlakuan. Hasil penelitian menunjukkan bahwa pupuk organik cair BIO-As dengan dosis 25 ml.l -1 mampu meningkatkan pertumbuhan tinggi tanaman, jumlah daun, jumlah batang,  dan bobot total tanaman kentang. Perlakuan P11 memiliki hasil yang paling baik dibandingkan perlakuan P0 hingga P10.
Hubungan kualitas air tercemar dengan keragaman gulma air di daerah aliran sungai Cikeruh dan Cikapundung Provinsi Jawa Barat
Authors: Kurniadie Denny , Putri D. V. , Umiyati Uum
Published: March 2020

Penelitian dilaksanakan pada bulan Mei sampai Agustus dengan tujuan untuk mengetahui keragaman gulma air  dan hubungan keberadaan gulma air yang tumbuh pada DAS Cikeruh dan DAS Cikapundung Propinsi Jawa Barat dengan kualitas air yang tercemar limbah pertanian, limbah pemukiman, dan limbah industri.  Metode penelitian metode weed survey dengan cluster sampling  diletakkan pada komunitas vegetasi di daerah hulu, tengah, dan hilir  sungai. Hasil penelitian menunjukkan bahwa gulma dominan tumbuh di sungai Cikeruh adalah : Drymaria cordata (L), daerah tengah dan hilir adalah: Eleusine indica (L), sedangkan gulma di DAS  Cikapundung bagian hulu adalah Drymaria cordata (L), daerah tengah dan hilir  adalah Ageratum conyzoides (L), dan Cyperus difformis (L). Nilai C sungai Cikeruh dan sungai Cikapundung menunjukkan lebih kecil dari 75% atau tidak terdapat kesamaan populasi, sedangkan nilai H’ termasuk dalam kategori rendah, dan nilai E termasuk dalam kategori sedang. Tidak terdapat korelasi antara keragaman jenis gulma dengan kualitas air di DAS Cikeruh dan DAS Cikapundung. Kata Kunci : dominasi gulma, pencemaran, keragaman gulma air
Pengaruh konsentrasi pupuk organik cair (POC) dan dosis pupuk N, P, K terhadap pertumbuhan dan hasil tanaman jagung manis (Zea mays L. var Rugosa Bonaf) kultivar talenta
Authors: Puspadewi S. , Sutari Wawan , Kusumiyati Kusumiyati
Published: March 2020

Percobaan bertujuan untuk mencari konsentrasi pupuk organik cair dan pupuk N, P, K yang terbaik  terhadap pertumbuhan dan hasil tanaman jagung manis kultivar Talenta. Percobaan dilaksanakan dari bulan Maret hingga Mei 2014 di Kebun Percobaan Fakultas Pertanian Universitas Padjadjaran, Jatinangor, Sumedang dengan ketinggian tempat ± 750 m di atas permukaan laut. Percobaan dilakukan menggunakan metode percobaan di lapangan dengan Rancangan Acak Kelompok (RAK) yang terdiri dari tujuh perlakuan dan diulang empat kali yaitu: 1 dosis rekomendasi pupuk N, P, K ; 1 kali konsentrasi  pupuk organik cair ; 2 kali konsentrasi pupuk organik cair ; 1 kali konsentrasi pupuk organik cair + ½ dosis pupuk N, P, K ; 1 kali konsentrasi pupuk organik cair + 1 dosis pupuk N, P, K ; 2 kali konsentrasi pupuk organik cair + ½ dosis pupuk N, P, K dan 2 kali konsentrasi pupuk organik cair + 1 dosis pupuk N, P, K. Hasil percobaan menunjukkan bahwa konsentrasi pupuk organik cair dengan dosis pupuk N, P, K berpengaruh terhadap tinggi tanaman, diameter batang, luas daun, panjang tongkol, diameter tongkol, berat tongkol, hasil tanaman, indeks panen dan total padatan terlarut. Berdasarkan pertimbangan dari segi ekologis dan ekonomis, kombinasi 1 kali konsentrasi pupuk organik cair dengan ½ dosis pupuk N, P, K mampu memberikan pengaruh yang lebih baik terhadap pertumbuhan dan hasil tanaman jagung manis.Kata kunci: jagung manis, pupuk organik cair, pupuk N, P, K
Aplikasi sitokinin untuk pematahan dormansi benih kentang G1 (Solanum tuberosum L.)
Authors: Nuraini Anne , Sumadi Sumadi , Pratama R.
Published: March 2020

Kentang merupakan komoditas pertanian yang mempunyai arti penting di dunia. Kentang mempunyai berbagai macam keunggulan seperti sumber protein yang tinggi, tidak mudah rusak seperti sayuran lain, dan berpotensi dalam program diversivikasi pangan. Salah satu kendala dalam produksi kentang adalah adanya fase dormansi pada masa pertumbuhan kentang. Upaya mempercepat masa dormansi tanaman adalah dengan penambahan hormon pemacu pertumbuhan. Sitokinin merupakan salah satu hormon pemacu pertumbuhan yang berperan dalam pembelahan sel. Tujuan dilakukannya penelitian ini adalah untuk mengetahui pengaruh konsentrasi sitokinin terhadap dormansi benih kentang. Penelitian ini dilakukan di laboratorium Teknologi Benih Fakultas Pertanian Universitas Padjadjaran. Sitokinin yang digunakan pada penelitian ini adalah Benzyl amino purine (BAP). Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan  6 perlakuan dan diulang empat kali, dilanjutkan dengan Uji Jarak Berganda Duncan. Perlakuan tersebut adalah berbagai  macam konsentrasi BAP yang terdiri dari 0 mgL-1, 50 mgL-1, 100 mgL-1, 150 mgL-1, 200 mgL-1 dan 250 mgL-1. Pengamatan dilakukan terhadap waktu muncul tunas, jumlah tunas, panjang tunas, bobot tunas, bobot benih dan diameter benih. Berdasarkan hasil penelitian dapat disimpulkan bahwa pemberian BAP berpengaruh nyata terhadap waktu muncul tunas, jumlah tunas, dan panjang tunas pada tanaman kentang, tetapi tidak berpengaruh nyata terhadap penurunan bobot basah benih dan penurunan diameter benih.  Kata kunci: Benih kentang, benzyl amino purine (BAP), dormansi tunas