bluuebunny/crossref_metadata_2025 huggingface dataset:
Методологічні засади психологічного забезпечення соціального прогнозування
Authors: Суший Олена
Published: January 2023

Метою статті є обґрунтування методологічних засад психологічного забезпечення соціального прогнозування як науково-теоретичної та предметно-практичної діяльності.

Методологія та наукові підходи. Дизайн теоретичної і методологічної аргументації передбачає уточнення та узгодження основних загальнометодологічних положень соціального аналізу в їх зв’язку із соціальним прогнозуванням і соціальною психологією та з акцентуванням уваги на прогностичних можливостях й обмеженнях останньої.

Основні результати. Проаналізовано та узгоджено рівні соціального/соціально-психологічного аналізу, що дає змогу визначитися щодо масштабу прогнозованих явищ і процесів. Уточнено методологічні принципи як загальнонаукового, так і спеціального (галузевого) рівнів у їх зв’язку із структурно-смисловою побудовою соціального аналізу, що задає аналітичні рамки для формулювання дворівневої системи методологічних принципів психологічного забезпечення соціального прогнозування. Узагальнення соціально-психологічних підходів і теоретичних моделей з підходами до дослідження майбутнього стало основою для налаштування інтегративних зв’язків між соціальним прогнозуванням і соціально-психологічною наукою. Запропоновано низку перспективних напрямів використання соціально-психологічних підходів для розроблення прогностичних стратегій і технологій повоєнного відновлення країни, чим унаочнюються можливості переходу від теоретичного до практичного соціально-психологічного забезпечення соціального прогнозування.

Висновки і перспективи подальших досліджень. Головний сенс порушення фахової дискусії навколо проблеми психологічного забезпечення соціального прогнозування та питань прогнозування соціальних явищ і процесів під специфічним – соціально-психологічним – кутом зору і за допомогою специфічних – соціально-психологічних – засобів полягає в тому, що активна інтервенція соціально-психологічних підходів у соціальне прогнозування – це єдиний шлях досягнення того, щоб знання про внутрішній (психічний) зміст соціальних явищ і процесів, про закономірності їх перебігу і розвитку стали реальною підставою для адекватних соціально-психологічних прогнозів і дієвих практичних рекомендацій.
TCMB’nin Covid-19 Salgını Sürecinde Uyguladığı Para Politikalarının Değerlendirilmesi
Authors: ÜLGER Özlem
Published: January 2023

2019 yılının son çeyreğinde ilk olarak Çin’in Hubei eyaleti Wuhan şehrinde görülen Covid-19 salgını, tüm dünyada hem ekonomi hem de insanlığın alışkanlıkları üzerinde olumsuz bir etkiye yol açmıştır. Koronavirüs salgının ortaya çıkardığı ekonomik krizin etkilerini azaltmaya yönelik hükümetler ciddi boyutlarda finansal destek paketleri açıklamışlardır. Ekonomik belirsizliklerin de artmasıyla birlikte küresel ekonomiyi desteklemeye yönelik doğru para ve maliye politikaları belirlenmeye çalışılmıştır. Türkiye’de de salgının olumsuz etkilerini azaltmak amacıyla sosyal ve ekonomik olarak tedbirler alınmaya başlanmıştır. Bu kapsamda TCMB tarafından koronavirüs salgınının olumsuz etkilerini sınırlandırmak ve ekonominin, üretimin, istihdamın olumsuz etkilerini azaltmak amacıyla “Ekonomik İstikrar Kalkanı” paketi açıklanmıştır. Bu çalışmamızda söz konusu ekonomi paketi değerlendirilecek ve uygulanan para politikaları 2010-2022 verileri kullanılarak ülkenin ekonomik değerlendirilmesi yapılacaktır
Characterization of the Unsaponifiable Fraction of Oils from the Pulp of Safous South in West of Democratic Republic of Congo
Authors: Mayele Kipoy David  , Gindo M. V.G.  , Tshiombe Mulumba Van  , Kakolongo Tumba Joséphine
Published: January 2023

The unsaponifiable fraction of oils from the pulp of safous was characterized through the study of essential oils and phytosterols. The essential oils found in the samples of the three zones showed qualitatively, the following composition: α-pinene, β-pinene, α-phellandrine, Benzene-1-methyl, phellandrene, 3-carene, caryophyllene. While higher alcohols and phytosterols found in the unsaponifiable Kinshasa were the 1-eicosanol, 1-Tétracosanol, 5-α-cholestane, 1-hexacosanol, 1-octacosanol, cholesterol, campesterol, Stigmasterol-1, 1-triacontanol, the β-sitosterol, and stigmastanol.
Pengaruh Modifikasi Knalpot Terhadap Performa dan Suhu Mesin Pada Sepeda Motor Satria F150
Authors: Saepuddin Ahmad , Tjiptady Bella Cornelia , Pradhana Candra , Rohman Mojibur , Meditama Ratna Fajarwati
Published: January 2023

Penelitian ini bertujuan mengkaji pengaruh perubahan gas buang terhadap performa dan suhu mesin pada sepeda motor dengan fokus pada merek Satria F 150. Dalam penelitian ini kami mengkaji beberapa pengaruh akibat perubahan aliran gas buang pada knalpot standar. Efek yang ingin Anda lihat adalah suhu, tekanan balik, torsi, dan tenaga mesin. Masing-masing efek ini dapat dilihat dengan tes dyno. Tenaga maksimum knalpot standar adalah 15,5 hp. pada 9027 rpm dan torsi maksimum mesin adalah 13,0 Nm pada 7974 rpm. Sementara itu, tenaga maksimal knalpot modifikasi tersebut adalah 15,3 hp. Pada 9119 rpm dan torsi maksimum mesin adalah 13,2 Nm pada 7182 rpm. Jadi tenaga atau performa knalpot racing lebih tinggi di 3000-7000rpm, sedangkan standar lebih rendah di 3000-7000rpm tapi lebih tinggi di 8000rpm. Data asupan menunjukkan sedikit torsi awal dan tenaga dengan knalpot balap dan knalpot stok, tetapi saat menggunakan knalpot yang dimodifikasi pada rpm rendah dan tinggi, ini menghasilkan lebih banyak tenaga dan torsi daripada knalpot stok, memberikan manfaat torsi dan torsi yang lebih efisien pada mesin. kekuasaan. Karena knalpot standar mengalami penyumbatan pada sistem pembuangan akibat ukuran pipa knalpot yang lebih kecil.
IMPLEMENTATION OF STUDENTS SOCIAL ATTITUDE IN THEMATIC LEARNING AT CLASS IVA OF ELEMENTARY SCHOOL
Authors: Yulandri Micko , Dafit Febrina
Published: January 2023

Social attitude refers to the becoming of students' social attitudes in order to make them honest, disciplined, responsible, and caring for others. The research described in this article is to describe the students’ becoming of social attitudes and obstacles found by teachers in applying social attitudes in thematic learning. The method used is descriptive research with a qualitative approach. The research involved students and homeroom teachers at class IVA. The data collection method is carried out by observation, interviews, and documentation. The results indicate that the circumstances in the research field teachers and students have already embedded social attitudes in the teaching and learning processes. The social attitudes that appeared in this research are tolerance, self-confidence, and mutual cooperation. The implementation of social attitudes is seen when group discussion and learning interactions in the classroom. Yet, the implementation of these social attitudes has not been applied optimally. It is due to several existing inhibition factors like students’ low self-awareness, uncontrolled associations, and children’s inner behavior. However, teachers should be tried to adapt themselves to students through socialization such as in school, family, and society. Various attempts are given by teachers in order to make students instill their social attitudes like maximizing the application of teaching and learning methods, linking the material with social attitudes, and providing guidance to apply learning methods in groups.
OPTIMALISASI KERJA KELOMPOK UNTUK MENINGKATKAN KETERAMPILAN GURU DALAM MENGGUNAKAN MEDIA PEMBELAJARAN DI TK NEGERI PEMBINA MEDANG KAMPAI DUMAI
Authors: Aida Aida
Published: January 2023

Penelitian ini dilatarbelakangi oleh rendahnya keterampilan guru dalam menggunakan media pembelajaran di TK Negeri Pembina Medang Kampai Dumai. Untuk itu perlu dilakukan suatu tindakan untuk mengatasi masalah tersebut, yaitu melalui kerja kelompok. Berdasarkan uraian pada latar belakang, identifikasi masalah dan pembatasan masalah, maka fokus penelitian ini berkaitan dengan peningkatan keterampilan guru dalam menggunakan media pembelajaran. Jenis penelitian adalah penelitian tindakan sekolah (PTS) yang bertujuan untuk mengetahui keberhasilan tentang peningkatan keterampilan guru dalam menggunakan media pembelajaran dalam mengajar melalui kerja kelompok di TK Negeri Pembina Medang Kampai Dumai. Berdasarkan hasil penyajian data dan pembahasan, maka dapat diambil kesimpulan bahwa pelaksanaan kerja kelompok dapat meningkatkan keterampilan guru dalam menggunakan media pembelajaran di TK Negeri Pembina Medang Kampai Dumai. Hal ini dapat dibuktikan dari temuan penelitian bahwa pada pra siklus rata-rata keterampilan guru dalam menggunakan media pembelajaran hanya 40%. Setelah dilaksanakan kerja kelompok pada siklus I, keterampilan guru dalam menggunakan media pembelajaran meningkat sebanyak 54%. Setelah dilakukan perbaikan tindakan dalam melaksanakan kerja kelompok pada siklus II, keterampilan guru dalam menggunakan media pembelajaran semakin meningkat sebanyak 83%. Sehingga pelaksanaan kerja kelompok dapat meningkatkan keterampilan guru dalam menggunakan media pembelajaran di TK Negeri Pembina Medang Kampai Dumai.
Electrocardiographic signs of Right Ventricular Sarcoidosis in A Collective of Arrhythmogenic Cardiomyopathy
Authors:   Chair of Cardiology, Ubbo Emmius Hospital, Osterstr. 110, 26506, Norden, Germany., Peters Stefan
Published: January 2023

Eletrocardiographic signs of right ventricular sarcoidosis have been reported as precordial R‘ exceeding 1.65mm2, right precordial T-wave inversions and low voltage in limb leads. The question was how often right ventricular sarcoidosis can be suggested in a collective of definite, borderline or possible arrhythmogenic cardiomyopathy.
Giant Cavernous Venous Vascular Malformation of Glans and Distal Penis in a Toddler Successfully Treated by Steroids and Subsequent Circumcision
Authors:   Departments of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt University Teaching Hospital, Rajkot 360001, Gujarat, India., Govani Devkumar J , Govani Neeva D ,   Departments of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt University Teaching Hospital, Rajkot 360001, Gujarat, India., Govani Dhaval R ,   Departments of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt University Teaching Hospital, Rajkot 360001, Gujarat, India., Panchasara Namrata G. ,   Departments of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt University Teaching Hospital, Rajkot 360001, Gujarat, India., Patel Rasila R. ,   Departments of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt University Teaching Hospital, Rajkot 360001, Gujarat, India., Kumar Midha Partap ,   J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan 307501, India affiliated to Medical Faculty of God Fatherly Spiritual University, Mount Abu, Rajasthan, India., Patel Ramnik V. ,   Departments of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt University Teaching Hospital, Rajkot 360001, Gujarat, India.
Published: January 2023

We wish to report a very rare and interesting case of a 3-year-old toddler boy who presented with request for cultural circumcision.
Boredom: Mike Leigh’sMeantimeand Working-Class Youth in Thatcher’s Britain
Authors: Jeon Bomi
Published: January 2023

This article traces the socio-cultural effect of neoliberalism on working-class youths by analysing Mike Leigh’s cinematic portrayal of boredom in Thatcher’s Britain, Meantime. As a state of disenchantment that stems from a sense of inadequacy, boredom in his films afflicts unemployed young people living in London, whose everyday life is pervaded by the sense of being excluded by the dominant national narrative of free-market capitalism. In various locations, boredom emerges in the daily experience of the characters, who feel the disconnection between officially sanctioned national aspirations and their own private sense of failure. For Mark and Colin, the city is an empty place where the demolition of traditional working-class culture has left them no story to tell about themselves. Exploring how the affective value of the national fantasy influences the reproduction of a lifestyle that can be inherently damaging to those who invest in it, I argue that boredom in the film nonetheless possesses an unexpected utility that runs counter to Thatcher’s neoliberal vision of development and progress, and provides these young people with an opportunity to reimagine ways of keeping on living together in a time of crisis.
Sâid b. Muhammed el-Üstüvâî’ye Göre Ebû Hanîfe’nin İtikadî Görüşleri
Authors: Birinci Züleyha
Published: January 2023

Sâid b. Muhammed el-Üstüvâî 432/1041 yılında vefat etmiş Hanefî fakihlerden biridir. Amelde olduğu gibi inançta da Ebû Hanîfe’ye tâbidir. el-İ‘tikad ve Muhtasaru Sâid isimli iki eserinin var olduğu bilinmektedir. Bunlardan sadece el-İ‘tikad günümüze gelebilmiştir. Üstüvâî’nin el-İ‘tikad isimli bu eseri Hanefî itikadını konu edinmiştir. Eserin önemli özelliklerinden biri, Ebû Hanîfe’nin akaid risâlelerinden sonra, Ebû Hanîfe’ye atfedilen itikadî görüşleri rivayetler halinde bir araya toplayan ilk eser olmasıdır. Bu açıdan Ebû Hanîfe’nin itikadî görüşleri hakkında yararlanılabilecek bir kaynaktır. Ancak Sâid b. Muhammed el-Üstüvâî tarafından İmam-ı Âzam Ebû Hanîfe’ye isnad edilen itikadî düşünceleri daha önce müstakil olarak inceleyen bir çalışma bulunmamaktadır. Bu sebeple bu makale, Üstüvâî’nin el-İ‘tikad isimli kitabında Ebû Hanîfe’ye atfedilen itikadî görüşler üzerinde duracaktır. Makale bunu yaparak Ebû Hanîfe’nin itikadî fikirleri hakkındaki diğer çalışmalara katkı sağlamayı hedeflemektedir. Makalede Ebû Hanîfe’ye atfedilen itikadî fikirlerin belirlenmesinde doküman incelemesi yönteminden istifade edilecektir. Ayrıca Ebû Hanîfe’nin akaid risâleleriyle karşılaştırmalar da yapılacaktır. Bu çalışmada Ebû Hanîfe’ye isnat edilen görüşler, kendi içlerinde gruplandırılarak incelenecektir.
Medical Brain Drain Scourge In Africa: Focusing on Nigeria
Authors: OFFIONG BASSEY ENO , Salibi G , Tzenios Nikolaos
Published: January 2023

This presentation discusses the ongoing brain drain crisis in the healthcare sector, focusing on Nigeria. Qualified clinical professionals like doctors, nurses, and pharmacists are well known to emigrate from developing countries to developed nations to practice. However, there is an alarming increase in this trend. The degree of brain drain among the health workforce has assumed frightening dimensions in Africa and, more notably, Nigeria. As a result of the brain drain issue, it is extremely difficult to meet the demand for labor in the healthcare industry and the greater economy of the sending countries. The topic of brain drain in Nigeria is not unique to one industry; however, the healthcare sector has experienced a significant loss. This presentation provides a background on the problem, its effects, and its consequences. It also gives specific recommendations to help minimize the flow.
Proposing an Educational Video: Preventing Airway Occlusion with Infants in Supported Sitting
Authors: Alston Margaret L. , Jambulingam Malliga
Published: January 2023

Sudden Unexpected Infant Death (SUID) includes the full spectrum of all infant death causes, which include “Determined” causes [e.g. Sudden Infant Death Syndrome (SIDS) at 42% and Accidental Suffocation and Strangulation at 24%], as well as “Undetermined” causes at 34% [1]. Literature is replete with studies that address the risk factors associated with SIDS, accounting for at least 42% of infant mortality [1]. Scarce to find, however, is public health education or learning opportunities that address the mechanism of brain injury and death by Positional Asphyxiation (PA). Better yet, in the current day of popular social media platforms and cell phone apps, there should be readily available video education on the topic where the focus is on PA risk factors and prevention. Viewing should be required of new parents and caretakers, as well as to health professionals, including pediatric clinical trainees who specialize in infant care. Other suggested locations for viewing would be hospital postpartum delivery suites and pediatric waiting rooms.The accidental but preventable phenomenon of PA gives rise to the annual occurrence rate of 2.8 – 3.0% (98-105 deaths) in healthy infants who have no pre-existing medical conditions, including prematurity. They die from SUID primarily in car seats, accounting for 69% of deaths in sitting devices [1]. Webster’s Dictionary defines PA as, “A condition of deficient oxygen supply to the brain and body which occurs when a person’s physical position prevents normal breathing.” Each tragic occurrence is first suspected, then largely confirmed by a combination of investigative reports and the absence of gross or observable findings from post-mortem autopsy--like tissue injury from traumatic injury or inflammatory changes. Additionally, there would be no recorded or known history of a pre-existing medical condition. Given these factors, post-autopsy typically confirms the cause of death as “Undetermined or Unknown.” Perhaps the combination of the low incidence rate of PA and “Undetermined” autopsy reports cause this mechanism of infant mortality to be an “unsung” category of SUID, thus remains in obscurity with respect to disseminated public health education.
Distribución altitudinal del género Charinus (Arachnida: Amblypygi: Charinidae) en América
Authors: Armas Luis F. de , Palomino-Cardenas Andrea C.
Published: January 2023

La presente contribución aborda la distribución altitudinal de las especies de amblipígidos del género Charinus Simon, 1892 en las Américas, un aspecto no estudiado previamente. Para ello se analizaron 75 artículos de taxonomía y ecología del grupo. La mayoría (62%) de estas especies habitan a menos de 301 m s.n.m.; 24.0% habitan entre los 301 y 600 m y solamente cuatro especies (5.0%) han sido reportadas de localidades situadas entre los 1201 y 1920 m s.n.m., siendo esta última la cota de máxima altitud registrada para el género en este continente. En América del Sur se localizan todas las especies americanas con un rango de distribución altitudinal por encima de los 1000 m, aunque en este subcontinente solamente Ecuador y Perú disponen de suficiente información al respecto.
Knowledge mapping concerning applications of nanocomposite hydrogels for drug delivery: A bibliometric and visualized study (2003–2022)
Authors: Wang Hao , Fu Hongxun , Fu Yefan , Jiang Lin , Wang Liye , Tong Haibin , Xie Zuoxu , Huang Peng , Sun Meiyan
Published: January 2023

Background: Nanocomposite Hydrogels (NHs) are 3D molecular networks formed by physically or covalently crosslinking polymer with nanoparticles or nanostructures, which are particularly suitable for serving as carriers for drug delivery systems. Many articles pertaining to the applications of Nanocomposite Hydrogels for drug delivery have been published, however, the use of bibliometric and visualized analysis in this area remains unstudied. The purpose of this bibliometric study intended to comprehensively analyze the knowledge domain, research hotspots and frontiers associated with the applications of Nanocomposite Hydrogels for drug delivery.

Methods: We identified and retrieved the publications concerning the applications of NHs for drug delivery between 2003 and 2022 from Web of Science Core Collection Bibliometric and visualized analysis was utilized in this investigative study.

Results: 631 articles meeting the inclusion criteria were identified and retrieved from WoSCC. Among those, 2,233 authors worldwide contributed in the studies, accompanied by an average annual article increase of 24.67%. The articles were co-authored by 764 institutions from 52 countries/regions, and China published the most, followed by Iran and the United States. Five institutions published more than 40 papers, namely Univ Tabriz (n = 79), Tabriz Univ Med Sci (n = 70), Islamic Azad Univ (n = 49), Payame Noor Univ (n = 42) and Texas A&M Univ (n = 41). The articles were published in 198 journals, among which the International Journal of Biological Macromolecules (n = 53) published the most articles, followed by Carbohydrate Polymers (n = 24) and ACS Applied Materials and Interfaces (n = 22). The top three journals most locally cited were Carbohydrate Polymers, Biomaterials and Advanced materials. The most productive author was Namazi H (29 articles), followed by Bardajee G (15 articles) and Zhang J (11 articles) and the researchers who worked closely with other ones usually published more papers. “Doxorubicin,” “antibacterial” and “responsive hydrogels” represent the current research hotspots in this field and “cancer therapy” was a rising research topic in recent years. “(cancer) therapeutics” and “bioadhesive” represent the current research frontiers.

Conclusion: This bibliometric and visualized analysis offered an investigative study and comprehensive understanding of publications regarding the applications of Nanocomposite Hydrogels for drug delivery from 2003 to 2022. The outcome of this study would provide insights for researchers in the field of Nanocomposite Hydrogels applications for drug delivery.
Kinetics of the serological response up to one year after tularemia
Authors: Lindgren Helena , Eklund Johan , Eneslätt Kjell , Sjöstedt Anders
Published: January 2023

Serological analysis is the predominant method used to diagnose tularemia, a zoonotic disease caused by the highly virulent bacterium F. tularensis. We determined F. tularensis-specific IgM and IgG antibody titers by an LPS-based ELISA assay on five occasions one to twelve months after onset of ulceroglandular tularemia in 19 individuals. Peak IgM antibody titers were observed at the one-month time point and peak IgG antibody titers at the two-month time point. Both IgG and IgM antibody levels declined linearly thereafter with rather similar kinetics. Compared to the average one-month antibody titers, average IgG titers were not significantly lower before the 12-month time point and IgM titers before the 4-month time point. All, but one average titer, were significantly increased compared to the cut-off of the assay. Average IgG and IgM titers were significantly lower for the group = 69 years old compared to the group < 69 years. Collectively, the data demonstrate a persistence of F. tularensis-specific IgM and IgG antibody titers for at least 12 months after ulceroglandular tularemia. Thus, low, but significantly elevated F. tularensis-specific antibody titers are of limited diagnostic value since they are not indicative of ongoing tularemia.
Enhancing organizational communication via intelligent voice assistant for knowledge workers: The role of perceived supervisor support, psychological capital, and employee wellbeing
Authors: Yin Bin , Wu Shu-Qi
Published: January 2023

In the world of globalization, knowledge workers have grown in importance to organizational development. Currently, the intelligence voice assistant (IVA) has a high degree of participation in people's lives, displaying a trend of becoming an emotional partner for humans. Therefore, whether the application of IVA can help enhance organizational communication for knowledge workers is worthy to be explored. This study adopted an interactive situation-simulation survey experiment to explore the impact of the application of IVA on knowledge workers' perceived supervisor support, psychological capital, and employee wellbeing, using a 2 (voice gender: male/female) by 2 (voice characteristics: machine-like/anthropomorphic) between-subject experimental design with two additional control groups (text-only/no-interaction). Besides, voice interviews were designed to understand what knowledge workers need from the IVA. Results show that: (1) There were pair-wise correlations among perceived supervisor support, psychological capital, and employee wellbeing of knowledge workers, and psychological capital played a complete mediating role between perceived supervisor support and employee wellbeing; (2) There were significant differences among the scores of different groups (the experimental groups, the text-only control group and the no-interaction control group) on perceived supervisory support and employee wellbeing, with the experimental groups overall better than the control groups. (3) Knowledge workers hope that the services provided by the IVA mainly include three categories: work support, emotional support and life support. In conclusion, this study shows that the use of IVA can significantly improve perceived supervisor support, psychological capital, and employee wellbeing of knowledge workers, and provide some useful directions for the product design.
Potential value of saline-induced Pd/Pa ratio in patients with coronary artery stenosis
Authors: Kiriyama Hiroyuki , Kiyosue Arihiro , Minatsuki Shun , Kawahara Takuya , Katsushika Susumu , Kamon Tatsuya , Hirose Kazutoshi , Shinohara Hiroki , Miura Mizuki , Saito Akihito , Kikuchi Hironobu , Kodera Satoshi , Hatano Masaru , Ando Jiro , Myojo Masahiro , Itoh Nobuhiko , Yamamoto Keisuke , Ikenouchi Hiroshi , Takeda Norifumi , Komuro Issei
Published: January 2023

Background

Fractional flow reserve (FFR) is the current gold standard for identifying myocardial ischemia in individuals with coronary artery stenosis. However, FFR is not penetrated as much worldwide due to time consumption, costs associated with adenosine, FFR-related discomfort, and complications. Resting physiological indexes may be widely accepted alternatives to FFR, while the discrepancies with FFR were found in up to 20% of lesions. The saline-induced Pd/Pa ratio (SPR) is a new simplified option for evaluating coronary stenosis. However, the clinical implication of SPR remains unclear.

Objectives

In the present study, we aimed to compare the accuracies of SPR and resting full-cycle ratio (RFR) and to investigate the incremental value of SPR in clinical practice.

Methods

In this multicenter prospective study, 112 coronary lesions (105 patients) were evaluated by SPR, RFR, and FFR.

Results

The overall median age was 71 years, and 84.8% were men. SPR was correlated more strongly with FFR than with RFR (r = 0.874 vs. 0.713, respectively; p < 0.001). Using FFR < 0.80 as the reference standard variable, the area under the receiver-operating characteristic (ROC) curve for SPR was superior to that of RFR (0.932 vs. 0.840, respectively; p = 0.009).

Conclusion

Saline-induced Pd/Pa ratio predicted FFR more accurately than RFR. SPR could be an alternative method for evaluating coronary artery stenosis and further investigation including elucidation of the mechanism of SPR is needed (225 words).
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocardial infarction in rats
Authors: Li Pingjiang , Wang Kang , Yin Jie , Qi Lei , Hu Hesheng , Yang Peijin , Shi Yugen , Li Yan , Feng Meng , Lyu Hangji , Ge Weili , Li Xiaolu , Yan Suhua
Published: January 2023

Objective

Sympathetic remodeling after myocardial infarction (MI) is the primary cause of ventricular arrhythmias (VAs), leading to sudden cardiac death (SCD). M1-type macrophages are closely associated with inflammation and sympathetic remodeling after MI. Long noncoding RNAs (lncRNAs) are critical for the regulation of cardiovascular disease development. Therefore, this study aimed to identify the lncRNAs involved in MI and reveal a possible regulatory mechanism.

Methods and results

M0- and M1-type macrophages were selected for sequencing and screened for differentially expressed lncRNAs. The data revealed that lncRNA LOC100911717 was upregulated in M1-type macrophages but not in M0-type macrophages. In addition, the lncRNA LOC100911717 was upregulated in heart tissues after MI. Furthermore, an RNA pull-down assay revealed that lncRNA LOC100911717 could interact with growth-associated protein 43 (GAP43). Essentially, immunofluorescence assays and programmed electrical stimulation demonstrated that GAP43 expression was suppressed and VA incidence was reduced after lncRNA LOC100911717 knockdown in rat hearts using an adeno-associated virus.

Conclusions

We observed a novel relationship between lncRNA LOC100911717 and GAP43. After MI, lncRNA LOC100911717 was upregulated and GAP43 expression was enhanced, thus increasing the extent of sympathetic remodeling and the frequency of VA events. Consequently, silencing lncRNA LOC100911717 could reduce sympathetic remodeling and VAs.
The feasibility and safety of combining atrial septal defect/patent foramen ovale and left atrial appendage closure: A systematic review and meta-analysis
Authors: Song Yi , Xing Hang , Koch Peter David , Li Xiaofei , Zhang Yan
Published: January 2023

Introduction

Atrial Septal Defect/Patent Foramen Ovale (ASD/PFO) occlusion is performed to prevent paradoxical embolism and reduce the risk of recurrent ischemic stroke. Left atrial appendage (LAA) closure is used as an alternative to medical therapy of non-valvular atrial fibrillation for prevention of stroke. Multiple studies have examined performing LAA and ASD/PFO occlusion. However, the feasibility and safety of combined occlusion of the left atrial appendage and ASD/PFO are not clear, furthermore, these studies are limited by their small sample sizes and retrospective analysis. In this study, we aimed to systematically review and meta-analyze the feasibility and safety of combining left atrial appendage and ASD/PFO closure.

Methods

PubMed, Web of Science, CNKI, Cochrane Library, Embase, and WanFang database were searched up to April 2022 to identify peer-reviewed human studies on assessing the feasibility, safety, and efficacy of combining left atrial appendage and ASD/PFO closure. The primary outcome was calculated: procedural feasibility outcome and procedural safety outcome.

Results

A total of 10 articles, including 340 patients from multiple countries, were included in the analysis. The principal findings of our study are: compared with single LAA closure, (i) combining PFO/ASD occlusion and LAA closure had similar procedural success proportion (98.43%, 95% CI: 96.67–100.00%), (ii) similar safety event incidences developed (1.67%, 95% CI: 0.24–3.92%), subgroup analyzed safety event incidences in death was 0.00 (95% CI: 0.00–0.33%), cardiac tamponade was 0.87% (95% CI: 0.00–2.77%), device embolization was 0.00 (95% CI: 0.00–0.60%), major bleeding was 0.00 (95% CI: 0.00–0.33%), stroke was 0.00 (95% CI: 0.00–0.02%).

Conclusion

Although this systematic review and meta-analysis demonstrate the technical feasibility and safety of combining closure of PFO/ASD and LAA, further studies of sufficient sample size, long-term follow-up, and rigor endpoint criteria are yet needed to fully evaluate this combination procedure for its role in clinical outcomes.
Prognostic value of interleukin-33, sST2, myeloperoxidase, and matrix metalloproteinase-9 in acute aortic dissection
Authors: Jia Yu , Li Dongze , Yu Jing , Jiang Wenli , Liu Yi , Li Fanghui , Li Wentao , Zeng Rui , Liao Xiaoyang , Wan Zhi
Published: January 2023

Background and purpose

Acute aortic dissection (AAD) is a life-threatening cardiovascular emergency. Both neutrophil granzyme and interleukin (IL)-33/ST2 systems have proven to be effective diagnostic markers for AAD. This study aimed to investigate the relationship between plasma IL-33, soluble suppression of tumorigenesis-2 (sST2), myeloperoxidase (MPO), and matrix metalloproteinase (MMP)-9 levels at admission and all-cause mortality in patients with AAD.

Methods

A total of 155 patients with AAD were enrolled from the Prospective Evaluation of Acute Chest Pain (PEACP) study. Plasma concentrations of IL-33, sST2, and MMP-9 were measured using an enzyme-linked immunosorbent assay, and MPO was detected using a chemiluminescence immunoassay. Aortic anatomical parameters were measured using CT radiography. The primary endpoint was all-cause mortality rate.

Results

The median age of the patients was 55 years, and 96 (61.9%) were diagnosed with type A-AAD. After adjusting for confounding factors, the highest tertiles of IL-33, sST2, MPO, and MMP-9 had hazard risks of 0.870 (95% CI: 0.412–1.836, P = 0.714), 3.769 (95% CI: 1.504–9.446, P = 0.005), 4.689 (95% CI: 1.985–11.076, P < 0.001), and 4.748 (95% CI: 1.763–12.784, P = 0.002), respectively, compared to the lowest tertile. Pearson’s correlation analysis revealed a significant correlation between these markers (P < 0.001). Moreover, sST2, MPO, and MMP-9 levels had a significant positive correlation with aortic diameter and pseudolumen area (P < 0.001).

Conclusion

The biomarkers sST2, MPO, and MMP-9 were independently associated with mortality in patients with AAD. The significant correlation between these biomarkers suggests a pathogenic role for the IL-33/ST2/neutrophil granzyme system in patients with AAD.
Fast imaging for the 3D density structures by machine learning approach
Authors: Li Yongbo , Chen Shi , Zhang Bei , Li Honglei
Published: January 2023

Residual Bouguer gravity anomaly inversion can be used to imaging for local density structures or to interpret near-surface anomalous mass distribution. The reasonable prior information is the crucial recipe for obtaining a realistic geological inversion result, especially for the ill-posed geophysical inversion problem. The conventional strategies introduce the prior constraints or joint multidisciplinary information in object function as regularization, and then use some optimization algorithm to minimize the object function. This process is called model-driven approach and is usually time-consuming. In recent years, the rapid development of machine learning technology has provided new solutions for solving geophysical inversion problems. Machine learning methods can reduce the dependence on prior information in the inversion process through setting special training datasets, and the time consumption of an inversion process executed by the trained model can be shortened by several orders of magnitude, which is conducive to fast inversion for the same type of application scenarios. In this study, we were inspired by the U-net model and develops the GV-Net (Gravity voxels inversion network) model using the convolutional neural network for the inversion of residual gravity anomalies. We first discussed the effects of different loss functions on the convergence speed of model training and prediction accuracy. Then, we analyzed the robustness of our model by changing noise levels of the datasets. At last, we employed this model in a real scenario. The results have demonstrated that the GV-Net model has the ability to deal with specific inverse problems by predefined training datasets.
Stratospheric PULSE–continental cold air outbreak coupling relationships: Interannual and interdecadal changes
Authors: Yu Yueyue , Yu Xueting , Guan Zhaoyong , Hu Dingzhu , Shi Chunhua , Guo Dong , Rao Jian
Published: January 2023

Stratospheric processes and their role in weather and climate have attracted increasing interests. The correspondence between the occurrence of pulse-like, stronger stratospheric poleward warm airmass transport (PULSE) events and the continental-scale cold air outbreak (CAO) events in northern hemispheric winter is found to be unstable from year to year. This increases the difficulties in utilizing the more predictable stratospheric variability in the sub-seasonal forecasts of CAOs, which can cause cold hazards. Using the ERA5 reanalysis data covering 37 winters (November–March) in the period 1979–2015, this study categorizes the CAO events over mid-latitudes of Eurasia (CAO_EA) and those over North America (CAO_NA) into two groups: those coupled with and those decoupled with the PULSE events. The coupled CAOs are further categorized into events that are, respectively, lead-coupled and lag-coupled with PULSEs. The intensity and affected area of extremely cold temperatures tend to be larger during CAOs that are coupled with PULSEs, particularly during the CAO_NA events that are lag-coupled with PULSEs and the CAO_EA events that are lead-coupled with PULSEs. Remarkable interannual and interdecadal variations are observed in the percentage of CAOs that are coupled with PULSEs for each winter, which is an important reference for determining the window of opportunity for skillful sub-seasonal forecasts of CAO by using the stratospheric signals. At both interdecadal and interannual timescales, a warm phase of the El Niño–Southern Oscillation (ENSO) in winter is favorable for the higher lag-coupling rate of CAO_NA and the lead-coupling rate of CAO_EA, and vice versa. The ENSO signals related to the interdecadal changes of the CAO coupling rate in winter can be traced back to the previous winter, while an ENSO phase transition from the previous winter to the current winter is closely related to the interannual changes of the CAO coupling rate.
Study on closing and cracking stress calculation method of fractured rock
Authors: Qiang Yue , Liu Gang , Xia Changsi , Li Shaohong , Li Li , Zhao Dongsheng , Zhou Ling , Cheng Longfei
Published: January 2023

Determining the characteristic stress intensity according to the rock stress-strain curve is significant significance for rock engineering. Nowadays, there are relatively mature methods for determining peak stress and damage stress. However, the crack volume strain method, axial strain method, and strain response method are more subjective to determine rock’s closure stress and initiation stress. The closure rock stress and crack initiation stress refined value method are proposed based on these methods, which are based on the discreteness of the rock stress and strain point. Through optimizing the stress characteristics by an objective function (variance function), the subjectivity of artificial observation is avoided; Based on the trend of rock stress-strain curve, an empirical method for determining rock closure stress and crack initiation stress is proposed. The test results indicate that the two proposed methods that calculate closure rock stress and crack initiation stress can obtain reasonable results. These methods can be used as a supplement to the characteristics of the rock stress determination method and can be used in actual engineering.
The safety factor of a heterogeneous slope in an open-pit metal mine: A case study from the Tanjianshan gold mine
Authors: Zhao Xingdong , Zhao Yifan , Yu Wenlong
Published: January 2023

A landslide of the north open-pit (323N) and the stability and design optimization of the south open-pit (323S) slope in the 323 belts of the Tanjianshan Gold Mine were studied. On 14 September 2020, a large landslide occurred on the east side of 323N, which posed a severe threat to the safety production of the mine. To avoid a similar slide on the south open-pit in the 323S, the limit equilibrium method was used to estimate the stability of the final slope of the designed initially open-pit in the 323N. The results show that the location and scale of the landslide are in good agreement with the three-dimensional laser scanning data. The effectiveness of the limit equilibrium method in slope stability analysis of the Tanjianshan Gold Mine was validated. The stability of the final slope of the initial design of 323S was analyzed. The sensitivity of the safety factor of homogeneous slope and heterogeneous rock slope to the bench face angle (BFA) and the difference of landslide type were compared and studied. When the spatial geometric relationship of rock masses with different lithology is complex, the engineering analogy method is inapplicable to calculation of parameters such as the BFA of heterogeneous rock slope and overall slope angle of the open-pit. The slope safety factor should be checked, and the slope step parameters are warranted to be optimized. The safety and economic benefits of the slope can be improved.
Depiction of immune heterogeneity of peripheral blood from patients with type II diabetic nephropathy based on mass cytometry
Authors: Jin Juan , Wang Longqiang , Liu Yongjun , He Wenfang , Zheng Danna , Ni Yinhua , He Qiang
Published: January 2023

Diabetic nephropathy (DN) is the most prominent cause of chronic kidney disease and end-stage renal failure. However, the pathophysiology of DN, especially the risk factors for early onset remains elusive. Increasing evidence has revealed the role of the innate immune system in developing DN, but relatively little is known about early immunological change that proceeds from overt DN. Herein, this work aims to investigate the immune-driven pathogenesis of DN using mass cytometry (CyTOF). The peripheral blood mononuclear lymphocytes (PBMC) from 6 patients with early-stage nephropathy and 7 type II diabetes patients without nephropathy were employed in the CyTOF test. A panel that contains 38 lineage markers was designed to monitor immune protein levels in PBMC. The unsupervised clustering analysis was performed to profile the proportion of individual cells. t-Distributed Stochastic Neighbor Embedding (t-SNE) was used to visualize the differences in DN patients’ immune phenotypes. Comprehensive immune profiling revealed substantial immune system alterations in the early onset of DN, including the significant decline of B cells and the marked increase of monocytes. The level of CXCR3 was dramatically reduced in the different immune cellular subsets. The CyTOF data classified the fine-grained differential immune cell subsets in the early stage of DN. Innovatively, we identified several significant changed T cells, B cell, and monocyte subgroups in the early-stage DN associated with several potential biomarkers for developing DN, such as CTLA-4, CXCR3, PD-1, CD39, CCR4, and HLA-DR. Correlation analysis further demonstrated the robust relationship between above immune cell biomarkers and clinical parameters in the DN patients. Therefore, we provided a convincible view of understanding the immune-driven early pathogenesis of DN. Our findings exhibited that patients with DN are more susceptible to immune system disorders. The classification of fine-grained immune cell subsets in this present research might provide novel targets for the immunotherapy of DN.
Effect of metal slots on the heating uniformity of multisource cavity microwave
Authors: Yin Shumeng
Published: January 2023

Microwave heating as a new type of heating has been widely used in numerous fields; however, microwave heating in multi-source cavity still poses several problems, including non-uniformity, low efficiency, restriction of the heating object, and “thermal runaway”, thus limiting the application of microwave energy. This study adopts a method to place a slotted layer in the cavity such that the energy can be radiated uniformly to improve the heating uniformity. The distribution of the electric field in the cavity is optimized by changing the arrangement and size of the slots in the slot layer. The effects of the slot arrangements are elucidated, and experiments are performed to study the real-life application of the slot arrangements. The results show that these metal slots are effective in improving the uniformity and efficiency of multisource cavity heating.
Machine visual technology based steel corrosion evaluation and analysis of power transformation lines: A Zhejiang power grid case study
Authors: Liu Sen , Hu Jiayuan , Qian Zhouhai , Song Xiaoning , Fang Xia
Published: January 2023

It can be seen that the corrosion failure of transmission and transformation equipment has increasingly restricted the safe operation of the Zhejiang power grid bottleneck problem. If effective anticorrosion measures are not taken promptly, transmission and transformation equipment serving in various sophisticated atmospheric environments will suffer serious corrosion damage in a relatively short period, which endangers the safe usage of transmission and transformation equipment and the security of grid operation. In this article, through the establishment of transmission and transformation steel components corrosion fracture mechanics model, a standard corrosion spectrum grading software based on DeepLabV3+ image segmentation technology is developed to determine the quantitative assessment method of corrosion damage and assess the corrosion status with safety degree of transmission and transformation equipment. According to the assessment results, the operation and maintenance units are guided to adopt differentiated corrosion maintenance and replacement strategies, so as to reduce corrosion safety hazards and reduce safety accidents and economic losses caused by corrosion, which is of great significance for the safe operation of power grids.
A robust flexibility evaluation method for distributed multi-energy microgrid in supporting power distribution system
Authors: Wang Jingxuan , Wu Zhi , Zhao Yating , Sun Qirun , Wang Fujue
Published: January 2023

Today’s power system is facing various challenges brought by large-scale renewable energy (RE) integration, which brings higher demand for flexibility. With the energy network gradually showing its distributed structural characteristics, multi-energy microgrids (MEMG) become an important component to effectively utilize distributed energy sources and supplement the flexibility of power distribution system (PDS). To effectively harness the operational flexibility of distributed MEMGs, we propose in this paper an evaluation method to quantify the flexibility capability of MEMG. A virtually established MG flexibility bus (MG-FB) is endowed with MG flexibility parameters (MG-FPs), which can reflect the flexibility characteristics of MEMG. To consider the impact of operational uncertainty on MG-FPs, a two-stage adaptive robust optimization (ARO) model is proposed, which can be solved by the C&CG algorithm. The results of a typical test system show the influence of system configuration, operator’s risk preference, and other factors on the values of MG-FPs. Besides, we illustrate the effectiveness and applicability of the proposed framework in modeling and quantifying the operational flexibility of MEMG to support the operation of the upstream network.
Coordination of network reconfiguration and mobile energy storage system fleets to facilitate active distribution network restoration under forecast uncertainty
Authors: Xu Yundai , Zhao Min , Wu Han , Xiang Sheng , Yuan Yue
Published: January 2023

The active distribution network (ADN) shows great potential for use in network restoration services, given its ability to actively control the network topology, distributed generation (DG) outputs, and demand response (DR) resources. However, its utility may be limited due to the geographical dispersion of DG and DR resources when applied to natural disasters such as windstorms, earthquakes, and floods. In addition, the increasing use of renewable energy creates fluctuations and uncertainties, hindering ADNs from realizing reliable energy scheduling during disasters. Mobile energy storage system (MESS) fleets can be used to economically provide flexible emergency power supply for network restoration services. MESSs can also hedge against load and DG output forecast risks. This article proposes a novel coordinated network reconfiguration and MESS fleets dispatching model considering the uncertainty in DG output and load forecasts to increase the resilience of the ADN after disasters. The MESS traveling strategy is modeled by an extended transit delay model. Then, a novel deterministic network restoration model incorporating the MESS, stationary energy storage system, DG, DR, and network reconfiguration is proposed and programmed using mixed-integer linear programming. Then, an ellipsoidal uncertainty set is employed to describe the uncertainty of load and DG output forecasts, and a robust network restoration model is proposed based on the deterministic one. The proposed deterministic and robust network restoration models are verified on a 59-bus rural distribution system in China.