bluuebunny/crossref_metadata_2025 huggingface dataset:
Rear Admiral (Astronaut) Alan Shepard: Ménière’s disease and the race to the moon
Authors: Menger Richard , Kelly Patrick , Fernando Shanik , Wolf Michael E. , Martino Anthony
Published: April 2019

On May 5, 1961, Alan B. Shepard Jr. piloted the Freedom 7 craft into a suborbital flight to become the first American man in space. His promising astronautical career was soon scuttled by spells of dizziness and tinnitus later diagnosed as Ménière’s disease, until William F. House—considered the father of neurotology and a pioneer in surgery for vestibular schwannomas—intervened. In 1968 House implanted an endolymphatic-subarachnoid shunt, which at the time was a virtually experimental procedure. Shepard’s debilitating Ménière’s disease was cured, but not quite in time for him to pilot the doomed Apollo 13 mission; he was reassigned to Apollo 14 and as a result would step foot on the moon on February 5, 1971. This historical vignette depicts the tale of how the career trajectories of Shepard and House—two notable figures in their respective fields—fatefully intersected.
Hybrid fluorescein-guided surgery for pituitary adenoma resection: a pilot study
Authors: Romano-Feinholz Samuel , Alcocer-Barradas Víctor , Benítez-Gasca Alejandra , Martínez-de la Maza Ernesto , Valencia-Ramos Cristopher , Gómez-Amador Juan Luis
Published: April 2019

OBJECTIVE

The authors conducted a pilot study on hybrid fluorescein-guided surgery for pituitary adenoma resection and herein describe the feasibility and safety of this technique.

METHODS

In this pilot study, the authors included all consecutive patients presenting with pituitary adenomas, functioning and nonfunctioning. They performed a hybrid fluorescein-guided surgical technique for tumor resection. An endonasal endoscopic approach was used; after exposure of the rostrum of the sphenoid sinus, they administered a bolus of 8 mg/kg of fluorescein sodium (FNa) intravenously, and during resection, they alternated between endoscopic and microscopic techniques to guide the resection under a YELLOW 560 filter.

RESULTS

The study included 15 patients, 7 men (47%) and 8 women (53%). Of the pituitary adenomas, 7 (46%) were nonfunctioning, 6 (40%) were GH secreting, 1 (7%) was prolactin secreting, and 1 (7%) was ACTH secreting. There were no FNa-related complications (anaphylactic reactions); yellowish staining of urine, skin, and mucosa was seen in all patients and resolved in a maximum time of 24 hours. After color spectrophotometric analysis, the authors identified a statistical difference in fluorescence among tumor, gland, and scar tissue (p = 0.01).

CONCLUSIONS

This is the first study of its kind to describe the feasibility and safety of using FNa to guide the resection of pituitary adenomas. The authors found this technique to be safe and feasible. It may be used to obtain better surgical results, especially for hormone-producing and recurring tumors, as well as for reducing the learning curve in pituitary adenoma surgery.
Front-line thrombectomy for acute large-vessel occlusion with underlying severe intracranial stenosis: stent retriever versus contact aspiration
Authors: Kang Dong-Hun , Yoon Woong , Baek Byung Hyun , Kim Seul Kee , Lee Yun Young , Kim Joon-Tae , Park Man-Seok , Kim Yong-Won , Kim Yong-Sun , Hwang Yang-Ha
Published: April 2019

OBJECTIVE

The optimal front-line thrombectomy choice for primary recanalization of a target artery remains unknown for patients with acute large-vessel occlusion (LVO) and an underlying intracranial atherosclerotic stenosis (ICAS). The authors aimed to compare procedural characteristics and outcomes between patients who received a stent-retriever thrombectomy (SRT) and patients who received a contact aspiration thrombectomy (CAT), as the front-line approach for treating LVO due to severe underlying ICAS.

METHODS

One hundred thirty patients who presented with acute LVO and underlying severe ICAS at the occlusion site were included. Procedural characteristics and treatment outcomes were compared between patients treated with front-line SRT (n = 70) and those treated with front-line CAT (n = 60). The primary outcomes were the rate of switching to an alternative thrombectomy technique, time from groin puncture to initial reperfusion, and duration of the procedure. Initial reperfusion was defined as revealing the underlying culprit stenosis with an antegrade flow after thrombectomy.

RESULTS

The rate of switching to an alternative thrombectomy after failure of the front-line technique was significantly higher in the CAT group than in the SRT group (40% vs 4.3%; OR 2.543, 95% CI 1.893–3.417, p < 0.001). The median time from puncture to initial reperfusion (17 vs 31 minutes, p < 0.001) and procedure duration (39 vs 75.5 minutes, p < 0.001) were significantly shorter in the SRT group than in the CAT group. In the binary logistic regression analysis, a longer time from puncture to initial reperfusion was an independent predictor of a 90-day poor (modified Rankin Scale score 3–6) functional outcome (per 1-minute increase; OR 1.029, 95% CI 1.008–1.050, p = 0.006).

CONCLUSIONS

The authors’ results suggest that SRT may be more effective than CAT for identifying underlying culprit stenosis and therefore considered the optimal front-line thrombectomy technique in acute stroke patients with LVO and severe underlying ICAS.
Whole exome sequencing–based analysis to identify DNA damage repair deficiency as a major contributor to gliomagenesis in adult diffuse gliomas
Authors: Ülgen Ege , Can Özge , Bilguvar Kaya , Oktay Yavuz , Akyerli Cemaliye B. , Danyeli Ayça Erşen , Yakıcıer M. Cengiz , Sezerman O. Uğur , Pamir M. Necmettin , Özduman Koray
Published: April 2019

OBJECTIVE

Processes that cause or contribute to cancer, such as aging, exposure to carcinogens, or DNA damage repair deficiency (DDRd), create predictable and traceable nucleotide alterations in one’s genetic code (termed “mutational signatures”). Large studies have previously identified various such mutational signatures across cancers that can be attributed to the specific causative processes. To gain further insight into the processes in glioma development, the authors analyzed mutational signatures in adult diffuse gliomas (DGs).

METHODS

Twenty-five DGs and paired blood samples were whole exome sequenced. Somatic mutational signatures were identified using 2 different methods. Associations of the signatures with age at diagnosis, molecular subset, and mutational load were investigated. As DDRd-related signatures were frequently observed, germline and somatic DDR gene mutations as well as microsatellite instability (MSI) status were determined for all samples. For validation of signature prevalence, publicly available data from The Cancer Genome Atlas (TCGA) were used.

RESULTS

Each tumor had a unique combination of signatures. The most common signatures were signature 1 (88%, aging related), signature 3 (52%, homologous recombination related), and signature 15 (56%, mismatch repair related). Eighty-four percent of the tumors contained at least 1 DDRd signature. The findings were validated using public TCGA data. The weight of signature 1 positively correlated with age (r = 0.43) while cumulative weight of DDRd signatures negatively correlated with age (r = −0.16). Each subject had at least 1 germline/somatic alteration in a DDR gene, the most common being the risk single nucleotide polymorphism rs1800734 in MLH1. The rs1800734-AA genotype had a higher cumulative DDRd weight as well as higher mutational load; TP53 was the most common somatically altered DDR gene. MSI was observed in 24% of the tumors. No significant associations of MSI status with mutational load, rs1800734, or the cumulative weight of DDRd signatures were identified.

CONCLUSIONS

Current findings suggest that DDRd may act as a fundamental mechanism in gliomagenesis rather than being a random, secondary event.
The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea
Authors: Nobis William P. , González Otárula Karina A. , Templer Jessica W. , Gerard Elizabeth E. , VanHaerents Stephen , Lane Gregory , Zhou Guangyu , Rosenow Joshua M. , Zelano Christina , Schuele Stephan
Published: April 2019

OBJECTIVE

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated respiratory depression as a pathophysiological mechanism. The brain regions responsible for a seizure’s inducing respiratory depression are unclear—the respiratory nuclei in the brainstem are thought to be involved, but involvement of forebrain structures is not yet understood. The aim of this study was to analyze intracranial EEGs in combination with the results of respiratory monitoring to investigate the relationship between seizure spread to specific mesial temporal brain regions and the onset of respiratory dysfunction and apnea.

METHODS

The authors reviewed all invasive electroencephalographic studies performed at Northwestern Memorial Hospital (Chicago) since 2010 to identify those cases in which 1) multiple mesial temporal electrodes (amygdala and hippocampal) were placed, 2) seizures were captured, and 3) patients’ respiration was monitored. They identified 8 investigations meeting these criteria in patients with temporal lobe epilepsy, and these investigations yielded data on a total of 22 seizures for analysis.

RESULTS

The onset of ictal apnea associated with each seizure was highly correlated with seizure spread to the amygdala. Onset of apnea occurred 2.7 ± 0.4 (mean ± SEM) seconds after the spread of the seizure to the amygdala, which was significantly earlier than after spread to the hippocampus (10.2 ± 0.7 seconds; p < 0.01).

CONCLUSIONS

The findings suggest that activation of amygdalar networks is correlated with central apnea during seizures. This study builds on the authors’ prior work that demonstrates a role for the amygdala in voluntary respiratory control and suggests a further role in dysfunctional breathing states seen during seizures, with implications for SUDEP pathophysiology.
Cognitive and cerebral hemodynamic effects of endovascular recanalization of chronically occluded cervical internal carotid artery: single-center study and review of the literature
Authors: Zanaty Mario , Howard Susanna , Roa Jorge A. , Alvarez Carlos M. , Kung David K. , McCarthy David J. , Samaniego Edgar A. , Nakagawa Daichi , Starke Robert M. , Limaye Kaustubh , Al Kasab Sami , Chalouhi Nohra , Jabbour Pascal , Torner James , Tranel Daniel , Hasan David
Published: April 2019

OBJECTIVE

Revascularization of a symptomatic, medically refractory, cervical chronically occluded internal carotid artery (COICA) using endovascular techniques (ETs) has surfaced as a viable alternative to extracranial-intracranial bypass. The authors aimed to assess the safety, success, and neurocognitive outcomes of recanalization of COICA using ETs or hybrid treatment (ET plus carotid endarterectomy) and to identify candidate radiological markers that could predict success.

METHODS

The authors performed a retrospective analysis of their prospectively collected institutional database and used their previously published COICA classification to assess the potential benefits of ETs or hybrid surgery to revascularize symptomatic patients with COICA. Subjects who had undergone CT perfusion (CTP) imaging and Montreal Cognitive Assessment (MoCA) testing, both pre- and postprocedure, were included. The authors then performed a review of the literature on patients with COICA to further evaluate the success and safety of these treatment alternatives.

RESULTS

The single-center study revealed 28 subjects who had undergone revascularization of symptomatic COICA. Five subjects had CTP imaging and MoCA testing pre- and postrevascularization and thus were included in the study. All 5 patients had very large penumbra involving the entire hemisphere supplied by the ipsilateral COICA, which resolved postoperatively. Significant improvement in neurocognitive outcome was demonstrated by MoCA testing after treatment (preprocedure: 19.8 ± 2.4, postprocedure: 27 ± 1.6; p = 0.0038). Moreover, successful revascularization of COICA led to full restoration of cerebral hemodynamics in all cases. Review of the literature identified a total of 333 patients with COICA. Of these, 232 (70%) showed successful recanalization after ETs or hybrid surgery, with low major and minor complication rates (3.9% and 2.7%, respectively).

CONCLUSIONS

ETs and hybrid surgery are safe and effective alternatives to revascularize patients with symptomatic COICA. CTP imaging could be used as a radiological marker to assess cerebral hemodynamics and predict the success of revascularization. Improvement in CTP parameters is associated with significant improvement in neurocognitive functions.
A comparison of endoscopic strip craniectomy and pi craniectomy for treatment of sagittal craniosynostosis
Authors: Magge Suresh N. , Bartolozzi Arthur R. , Almeida Neil D. , Tsering Deki , Myseros John S. , Oluigbo Chima O. , Rogers Gary F. , Keating Robert F.
Published: April 2019

OBJECTIVE

Sagittal craniosynostosis is managed with a wide variety of operative strategies. The current investigation compares the clinical outcomes of two widely performed techniques: pi craniectomy and minimally invasive endoscopic strip craniectomy (ESC) followed by helmet therapy.

METHODS

This IRB-approved retrospective study examined patients diagnosed with nonsyndromic, single-suture sagittal craniosynostosis treated with either pi craniectomy or ESC. Included patients had a minimum postoperative follow-up of 5 months.

RESULTS

Fifty-one patients met the inclusion criteria (pi 21 patients, ESC 30 patients). Compared to patients who underwent ESC, the pi patients were older at the time of surgery (mean age 5.06 vs 3.11 months). The mean follow-up time was 23.2 months for ESC patients and 31.4 months for pi patients. Initial cranial index (CI) was similar between the groups, but postoperatively the ESC patients experienced a 12.3% mean increase in CI (from 0.685 to 0.767) compared to a 5.34% increase for the pi patients (from 0.684 to 0.719), and this difference was statistically significant (p < 0.001). Median hospital length of stay (1 vs 2 days) and operative duration (69.5 vs 93.3 minutes) were significantly less for ESC (p < 0.001 for both). The ESC patients showed a trend toward better results when surgery was done at younger ages. Craniectomy width in ESC cases was positively associated with CI improvement (slope of linear regression = 0.69, p = 0.026).

CONCLUSIONS

While both techniques effectively treated sagittal craniosynostosis, ESC showed superior results compared to pi craniectomy. ESC showed a trend for better outcomes when done at younger ages, although the trend did not reach statistical significance. A wider craniectomy width (up to 2 cm) was associated with better outcomes than smaller craniectomy widths among the ESC patients.
Heterotopic ossification following suboccipital craniectomy decompression surgery for Chiari malformation type I: case report
Authors: Louie Christopher E. , Hong Jennifer , Bauer David F.
Published: April 2019

Suboccipital craniectomy with duraplasty is a commonly performed procedure for children with symptomatic Chiari malformation type I (CM-I). Several dural substitutes are used for duraplasty, ranging from pericranium to synthetic materials. When available, autologous pericranium is often preferred due to its low cost, performance in obtaining a watertight closure, ease of suturing, and absence of immune reaction. Long-term follow-up data on the durability of various dural substitutes are lacking. The authors report a rare, long-term complication of duraplasty performed using an autologous pericranial graft, and they conduct a literature review of similar complications. Heterotopic ossification of an autologous pericranial graft is a rare complication of duraplasty. This dystrophic bone growth can be symptomatic due to compression of neural structures, and it requires reoperation for removal. Surgeons should consider this rare long-term complication in patients presenting with unusual symptoms after duraplasty with pericranium.
Outpatient and inpatient readmission rates of 3- and 4-level anterior cervical discectomy and fusion surgeries
Authors: Khalid Syed I. , Kelly Ryan , Carlton Adam , Adogwa Owoicho , Kim Patrick , Ranade Arjun , Moreno Jessica , Maasarani Samantha , Wu Rita , Melville Patrick , Citow Jonathan
Published: April 2019

OBJECTIVE

With the costs related to the United States medical system constantly rising, efforts are being made to turn traditional inpatient procedures into outpatient same-day surgeries. In this study the authors looked at the various comorbidities and perioperative complications and their impact on readmission rates of patients undergoing outpatient versus inpatient 3- and 4-level anterior cervical discectomy and fusion (ACDF).

METHODS

This was a retrospective study of 337 3- and 4- level ACDF procedures in 332 patients (5 patients had both primary and revision surgeries that were included in this total of 337 procedures) between May 2012 and June 2017. In total, 331 procedures were analyzed, as 6 patients were lost to follow-up. Outpatient surgery was performed for 299 procedures (102 4-level procedures and 197 3-level procedures), and inpatient surgery was performed for 32 procedures (11 4-level procedures and 21 3-level procedures). Age, sex, comorbidities, number of fusion levels, pain level, and perioperative complications were compared between both cohorts.

RESULTS

Analysis was performed for 331 3- and 4-level ACDF procedures done at 6 different hospitals. The overall 30-day readmission rate was 1.2% (outpatient 3 [1.0%] vs inpatient 1 [3.1%], p = 0.847). Outpatients had increased readmission risk, with comorbidities of coronary artery disease (OR 1.058, p = 0.039), autoimmune disease (OR 1.142, p = 0.006), diabetes (OR 1.056, p = 0.001), and chronic kidney disease (OR 0.933, p = 0.035). Perioperative complications of delirium (OR 2.709, p < 0.001) and surgical site infection (OR 2.709, p < 0.001) were associated with increased risk of 30-day hospital readmission in outpatients compared to inpatients.

CONCLUSIONS

This study demonstrates the safety and effectiveness of 3- and 4-level ACDF surgery, although various comorbidities and perioperative complications may lead to higher readmission rates. Patient selection for outpatient 3- and 4-level ACDF cases might play a role in the safety of performing these procedures in the ambulatory setting, but further studies are needed to accurately identify which factors are most pertinent for appropriate selection.
Do untreated intraspinal anomalies in congenital scoliosis impact the safety and efficacy of spinal correction surgery? A retrospective case-control study
Authors: Zhao Qinghua , Shi Benlong , Sun Xu , Liu Zhen , Su Hao , Li Yang , Zhu Zezhang , Qiu Yong
Published: April 2019

OBJECTIVE

Intraspinal anomalies associated with congenital scoliosis (CS) complicate the decision-making process for spinal correction surgery in CS patients. Recently, deformity correction surgery without prior prophylactic neurological intervention has been recognized to be safe in CS patients with intact or stable neurological status. However, no case-control study has identified the surgical outcomes and risks of spinal correction surgery in this patient population. The authors sought to investigate the safety and efficacy of spinal correction surgery for CS associated with untreated intraspinal anomalies (split cord malformation [SCM], tethered cord, and/or syringomyelia) with intact or stable neurological status.

METHODS

A group of CS patients with intraspinal anomalies (CS+IA) and another group of CS patients without intraspinal anomalies (CS-IA) undergoing 1-stage posterior correction surgery were retrospectively reviewed. The radiographic and clinical outcomes and postoperative complications were compared between the 2 groups.

RESULTS

There were 57 patients in the CS+IA group and 184 patients in the CS-IA group. No significant difference was observed in age, sex, spinal curve pattern, main Cobb angle, and flexibility of the main curve between the 2 groups (p > 0.05 for all). The postoperative correction rates of the major curve were comparable between the 2 groups (53.5% vs 55.7% for the CS+IA and CS-IA groups, respectively, p > 0.05). No significant difference was observed in the incidence of either implant-related or neurological complications between 2 groups. No patients in the CS+IA group developed neurological complications, whereas 1 patient in the CS-IA group experienced transient weakness of the left lower extremity after surgery.

CONCLUSIONS

Coexisting intraspinal anomalies (SCM, tethered cord, and/or syringomyelia) in CS patients with normal or stable neurological status do not significantly increase the risk of neurological complications of correction surgery. Prophylactic neurosurgical intervention for intraspinal anomalies before correction surgery might be unnecessary for these patients.
Comparative study of multilevel posterior interbody fusion plus anterior longitudinal ligament release versus classic multilevel posterior interbody fusion in the treatment of adult spinal deformities
Authors: Sabou Silviu , Lagaras Apostolos , Verma Rajat , Siddique Irfan , Mohammad Saeed
Published: April 2019

OBJECTIVE

Sagittal imbalance and loss of lumbar lordosis are the main drivers of functional disability in adult degenerative scoliosis. The main limitations of the classic posterior lumbar interbody fusion technique are increased risk of neurological injury and suboptimal correction of the segmental lordosis. Here, the authors describe the radiological results of a modified posterior lumbar interbody fusion and compare the results with a historical cohort of patients.

METHODS

Eighty-two consecutive patients underwent surgical treatment for degenerative scoliosis/kyphosis in a single tertiary referral center for complex spinal surgery. Fifty-five patients were treated using the classic multilevel posterior lumbar interbody fusion (MPLIF) technique and 27 were treated using the modified MPLIF technique to include a release of the anterior longitudinal ligament (ALL) and the annulus. A radiographic review of both series of patients was performed by two independent observers. Functional outcomes were obtained, and patients were registered in the European Spine Tango registry.

RESULTS

The mean L4–5 disc angle increased by 3.14° in the classic MPLIF group and by 12.83° in MPLIF plus ALL and annulus release group. The mean lumbar lordosis increased by 15.23° in the first group and by 25.17° in the second group. The L4–S1 lordosis increased on average by 4.92° in the classic MPLIF group and increased by a mean of 23.7° in the MPLIF plus ALL release group when both L4–5 and L5–S1 segments were addressed. There were significant improvements in the Core Outcome Measures Index and EQ-5D score in both groups (p < 0.001). There were no vascular or neurological injuries observed in either group.

CONCLUSIONS

The authors’ preliminary results suggest that more correction can be achieved at the disc level using posterior-based ALL and annulus release in conjunction with posterior lumbar interbody fusion. They demonstrate that ALL and annulus release can be performed safely using a posterior-only approach with minimal risk of vascular injury. However, the authors recommend that this approach should only be used by surgeons with considerable experience in anterior and posterior spinal surgery.
A study of pediatric cerebral arteriovenous malformations: clinical presentation, radiological features, and long-term functional and educational outcomes with predictors of sustained neurological deficits
Authors: Ravindra Vijay M. , Bollo Robert J. , Eli Ilyas M. , Griauzde Julius , Lanpher Arianna , Klein Jennifer , Zhu Huirong , Brockmeyer Douglas L. , Kestle John R. W. , Couldwell William T. , Scott R. Michael , Smith Edward
Published: April 2019

OBJECTIVE

Large experiences with the treatment of pediatric arteriovenous malformations (AVMs) remain relatively rare, with limited data on presentation, treatment, and long-term functional outcomes. Because of the expected long lifespan of children, caregivers are especially interested in outcome measures that assess quality of life. The authors’ intention was to describe the long-term functional outcomes of pediatric patients who undergo AVM surgery and to identify predictors of sustained neurological deficits.

METHODS

The authors analyzed a 21-year retrospective cohort of pediatric patients with intracranial AVMs treated with microsurgery at two institutions. The primary outcome was a persistent neurological deficit at last follow-up. Secondary outcome measures included modified Rankin Scale (mRS) score and independent living.

RESULTS

Overall, 97 patients (mean age 11.1 ± 4.5 years; 56% female) were treated surgically for intracranial AVMs (mean follow-up 77.5 months). Sixty-four patients (66%) presented with hemorrhage, and 45 patients (46%) had neurological deficits at presentation. Radiologically, 39% of lesions were Spetzler-Martin grade II. Thirty-seven patients (38%) with persistent neurological deficits at last follow-up were compared with those without deficits; there were no differences in patient age, presenting Glasgow Coma Scale score, AVM size, surgical blood loss, or duration of follow-up. Multivariate analysis demonstrated that a focal neurological deficit on presentation, AVM size > 3 cm, and lesions in eloquent cortex were independent predictors of persistent neurological deficits at long-term follow-up. Overall, 92% of the children had an mRS score ≤ 2 on long-term follow-up.

CONCLUSIONS

Pediatric patients with AVMs treated with microsurgical resection have good functional and radiological outcomes. There is a high rate (38%) of persistent neurological deficits, which were independently predicted by preoperative deficits, AVMs > 3 cm, and lesions located in eloquent cortex. This information can be useful in counseling families on the likelihood of long-term neurological deficits after cerebral AVM surgery.
Bagaimana Merancang Sistem Manajemen Kinerja
Authors: Rahardja Wienda Primadyansyah
Published: April 2019

Purpose - Makalah ini mengusulkan model manajemen kinerja berdasarkan teori-teori yang ada.Design/Methodology/Approach - Konsep paper ini mengeksplorasi sistem manajemen kinerja dengan teori-teori yang telah dikumpulkan dengan menggunakan metode kualitatif.Findings – Makalah ini mampu menemukan model perancangan sistem manajemen kinerja dengan pendekatan benchmarking dan balanced scorecardResearch Limitations/Implications – Penerapan model perancangan ini masih sedikit perusahaan di Indonesia yang mampu menerapkanPractical Implications – Memberikan gambaran model sistem manajemen kinerja yang kompleks bagi perusahaan yang membutuhkan dan akan menerapkannyaOriginality/Value - Makalah ini relevan bagi praktisi dan akademisi, karena memperjelas pengetahuan yang ada dan menyediakan platform untuk penelitian selanjutnyaKeywords - Performance Management, Performance Measurement, Benchmarking, Balanced Scorecard, KPIPaper type - Conceptual Paper
Transformasi Digital Media Cetak Di Indonesia: Studi Pada Industri Media Cetak Terferivikasi Administratif Dan Faktual 2017
Authors: PRIHANTO JOHNY NATU
Published: April 2019

Kehadiran tehnologi baru, internet dan digitalisasi, menjadi tantangan sekaligus peluang bagi industri media cetak di Indonesia. Menghadapi kecepatan penggunaan internet dan digitalisasi, industri media cetak di Indonesia menghadapi dua persoalan utama: di satu sisi terjadi penurunan drastis pendapatan dari sektor iklan, sirkulasi, dan keterbacaan (readership), sementara di sisi lain pendapatan dari  web advertising (digital) belum mampu menggantikan hilangnya pendapatan di sektor cetak. Maka perlu ditetapkan strategi baru untuk membangun keterlibatan pelanggan yang unik dan khusus (niche). Karena bagi pengiklan, prioritasnya adalah mencari cara untuk berada lebih dekat dengan pelanggannya (audience).

Hasil studi ini menunjukkan bahwa kapabilitas organisasi dalam melakukan rekonfigurasi sumberdaya memiliki peran dalam mempengaruhi kinerja kapabilitas pasar digital, kapabilitas kepemimpinan digital dan kapabilitas teknologi digital yang secara bersama berperan dalam mempengaruhi kinerja transformasi digital dalam membangun dan memperkuat keterlibatan pelanggan. Bagi teori manajemen strategik studi ini memberikan kontribusi bahwa variable-variabel yang diteliti dan diukur memiliki peran dalam menjawab disrupsi digital. Sedangkan dari aspek empirik studi ini membantu para manajer dalam menetapkan fokus pada faktor-faktor yang membangun transformasi digital berkelanjutan dan penetapan strategi dalam membangun dan mengembangkan keterlibatan pelanggan.

 

Keywords: dynamic capabilities, capability to reconfigure resources/assets, digital market capabilities, digital leadership capabilities, digital capabilities, sustainable digital transformation, engaging audience strategy.
Pembingkaian Pemberitaan Nonton Bareng Film G30S/PKI di Media Daring
Authors: Khoironi Luthfian , Fitriawan Rana Akbari
Published: April 2019

Penelitian ini bertujuan untuk melihat bagaimana pemberitaan mengenai isu pro dan kontra terhadap pemutaran film G30S/PKI yang dibingkai oleh dua media daring, yakni Detik.com dan Kompas.com, pada periode September 2017. Metode analisis yang digunakan penulis pada penelitian ini adalah analisis framing model Zhongdang Pan dan Kosicki. Metode penelitiannya adalah metode penelitian kualitatif dan menggunakan paradigma konstruktivisme. Hasil dari penelitian menunjukkan bahwa media daring Detik.com terlihat lebih cenderung menganggap bahwa pemutaran film G30S/PKI merupakan suatu hal yang wajar jika dipertontonkan kepada masyarakat. Hal tersebut terlihat dengan cara Detik.com berusaha menyembunyikan beberapa fakta mengenai pemberitaan yang disajikan. Sedangkan Kompas.com terlihat lebih cenderung menganggap bahwa pemutaran film G30SPKI merupakan suatu hal yang tidak pantas untuk wajib dipertontonkan. Kesimpulan dari penelitian ini adalah terlihat perbedaan yang cukup signifikan antara media daring Detik.com dan Kompas.com dalam membingkai sebuah berita mengenai pemutaran film G30S/PKI  pada periode yang sama.

Kata Kunci: Berita, media daring, nonton bareng Film G30S/PKI, konstruksi media massa
Kebijakan Redasional Majalah Gadis dalam Membuat Konten Digital
Authors: Novel Past
Published: April 2019

Perkembangan media massa turut mengikuti perkembangan teknologi di mana kini internet mempermudah segala akses informasi, baik penerimaan maupun penyebarannya. Majalah adalah salah satu media massa yang kini juga memanfaatkan perkembangan teknologi dan internet dalam bentuk digital atau daring. Kelebihan penggunaan internet dalam mengakses media massa adalah kemudahan, interaktivitas, dan mengurangi biaya produksi dan distribusi. Di samping kelebihannya, terdapat juga beberapa risiko dan efek samping dari popularitas media massa dalam bentuk digital atau daring. Majalah GADIS, salah satu majalah remaja Indonesia yang telah terbit sejak 35 tahun lalu, turut meramaikan dunia daring dengan menerbitkan versi online majalahnya. Peneliti mewawancara pihak redaksi Majalah Gadis dan menganalisis konten digital Majalah Gadis. Mengambil fokus sudut pandang redaksional, penelitian ini menganalisis langkah-langkah dan pertimbangan apa yang direncanakan oleh media ini. Temuan ini diharapkan dapat menguak sudut pandang redaksi Majalah GADIS dalam mengantisipasi dan menyikapi risiko penggunaan teknologi, terutama majalah digital dan daring.

Kata kunci: media massa, majalah, online, media digital
Pengaruh Advertorial mengenai CSR dalam Pembentukan Citra Merek
Authors: Primadini Intan
Published: April 2019

Penelitian ini bertujuan untuk mengetahui pengaruh tingkat kredibilitas advertorial terhadap persepsi khalayak mengenai isi advertorial tentang corporate social responsibility (CSR) yang dilakukan oleh Lifebuoy dan untuk mengetahui pengaruh persepsi khalayak mengenai CSR tersebut terhadap brand image (citra) Lifebuoy, serta untuk mengetahui adakah perbedaan persepsi mengenai CSR yang dilakukan Lifebuoy dan citra merek Lifebuoy antara pemakai dan bukan pemakai. Paradigma yang digunakan adalah positivis dan bersifat eksplanatif. Pengumpulan data dilakukan dengan menggunakan metode survei melalui kuesioner. Populasi penelitian ini adalah mahasiswa Ekstensi FISIP UI. Sampelnya berjumlah 60 orang yang diambil secara acak. Kesimpulan yang dapat ditarik dari penelitian ini adalah tingkat kredibilitas advertorial memiliki pengaruh yang signifikan terhadap persepsi mengenai CSR, sementara persepsi mengenai CSR juga memiliki pengaruh yang signifikan terhadap citra merek Lifebuoy, serta tidak ada perbedaan persepsi yang signifikan antara pemakai maupun non-pemakai Lifebuoy mengenai CSR dan citra merek.

Kata Kunci: Advertorial, citra merek, Lifebuoy, marketing public relations, tanggung jawab sosial
Investigations on maladaptive plasticity in the sensorimotor cortex of unilateral upper limb CRPS I patients
Authors: Pfannmöller J. , Strauss S. , Langner I. , Usichenko T. , Lotze M.
Published: April 2019

Background:

Patients with a complex regional pain syndrome (CRPS) in the upper limb show a sensory and motor impairment of the hand. Decreased intra-cortical-inhibition (ICI) of the motor representation of the affected hand muscle and decreased somatosensory hand representation size were related to maladaptive plasticity.

Objective:

To achieve new insights about CRPS we examined whether these alterations were present in a single cohort.

Methods:

We used a multi-modal approach comprising behavioral testing, transcranial magnetic stimulation, and high resolution fMRI combined with a new analysis technique for improved neuronal specificity.

Results:

We found a decreased pinch-grip performance, two-point discrimination on the fingertips, ICI in the motor cortex, and representation size of the hand in Brodmann Area 3b (BA3b) in the somatosensory cortex. Our analysis further showed that correlations with ICI on the non-affected side were absent on the affected side.

Conclusions:

This study is the first to gather behavioral, neurophysiologic and imaging measurements for one patient cohort and it therefore enables a comprehensive view of collapsed associations of function and representation focused on the hemisphere contralateral to the affected hand.
Perancangan dan Implementasi Sistem Informasi Layanan Kesehatan Masyarakat
Authors: Hermanto Dedy , Pradesan Iis
Published: April 2019

Ketersediaan informasi untuk masyarakat oleh penyelenggara kesehatan seperti Rumah Sakit dan Palang Merah Indonesia merupakan hal penting untuk dikaji dan terus dibenahi mengingat pada siklus ini melibatkan kepentingan banyak orang dan membutuhkan waktu respon yang cepat. sebagai contoh kebutuhan informasi rawat inap, informasi dokter jaga, informasi nomor antrian oleh Rumah Sakit dan informasi ketersediaan darah oleh Palang Merah Indonesia. Ketersediaan akan informasi itulah yang diangkat oleh peneliti Pelayanan kesehatan yang baik merupakan salah satu hal yang diinginkan oleh setiap orang terutama pelayanan dibidang kesehatan salah satunya adalah ketersediaan informasi yang cepat. Akses informasi yang cepat dan akurat dari rumah sakit dan Palang Merah Indonesia (PMI) sangat dibutuhkan oleh setiap orang pengguna jasa pelayanan kesehatan. Agar kegiatan ini dapat berjalan secara optimal, aplikasi sistem informasi yang berbasis web dan perangkat bergerak dapat menjadi salah satu solusi. Dalam penelitian ini penulis menggunakan Metodologi Rational Unified Process (RUP), Meotodologi ini memiliki 4 fase yaitu Inception, Elaboration, Construction and Transition. Penelitian ini menghasilkan Sistem informasi yang menggunakan 2 basis aplikasi yaitu web dan perangkat bergerak, berguna untuk memberikan informasi yang tepat tentang keberadaan kamar, dokter yang bertugas, stok darah yang ada dan antrian pasien yang akan melakukan rawat inap di sebuah rumah sakit. Dari hasil penelitian ini hasil yang diharapkan yaitu setiap pasien mendapat pelayanan yang cepat dan baik, serta informasi yang didapat merupakan informasi yang akurat dan cepat
EDITORIAL
Authors: Jurnal Admin
Published: April 2019

EDITORIAL
INDEX PENULIS
Authors: Jurnal Teknodik Redaksi
Published: April 2019

INDEX PENULIS
A Stock Prices Prediction Approach Via Neural Network by Several Investor Indicators
Authors: Chen Yahui , Wen Zhan , Li Qi , Pan Yuwen , Zu Xia , Li Wenzao
Published: April 2019

The prediction of stock indicators such as prices, trends and market indices is the focus of researchers. However, stock market has the characteristics of high noise and non-linearity. Generally, linear algorithms are not good for predicting stock market indicators. Therefore, BP neural network, a model suitable for nonlinear task, is widely used in stock market forecasting. However, many BP neural network prediction models are only based on historical stock quantitative data, and do not consider the impact of investor behavior on the stock market. Therefore, based on historical stock data and quantitative data of investor behavior of ten selected Chinese stocks, this paper trains a three-layer BP neural network to predict the stock prices such as the highest price ,the opening price ,the closing price, the lowest price in a short term. And then, the model that incorporates the investor behavior indicator is compared with the model that is not added. The results show that investor behavior indicators can improve the accuracy and generalization of the stock price forecasting model effectively, especially when the model based on stock quantitative data has a poor prediction accuracy on the test set.
Automatic Street Light Control and Fault Detection Using Node - MCU
Authors: Kumar T. Santosh , Rao G. Joga , Ramana J. Appala , Sai Ganesh. B M. Chaitanya , Vennela T. , Krishna M. Murali
Published: April 2019

Objective of the project is to provide automatic control and fault detection on street lamps. The lighting system which targets the energy and automatic operation on economical affordable for the streets and immediate information response about the street lamp fault. Moreover, errors which occur due to manual operation can also eliminate. The street light switched ON/OFF through an Internet of Things (IOT). The street light system is checking the weather for street lamp ON/OFF condition. The weather is noted through an LDR sensor, If the weather is bright , the system will OFF. If the weather is dark, the light system will ON. After the light ON the light condition also check through LDR sensor for glow or not glow status. If light is not glowing, the sensor sends the value to street light system. The street light system will generate message and send SMS to ward member and ward serviceman mobile number.
Performance Analysis of Mobile Wireless Sensor Network with Energy Efficient and Reliable Routing
Authors: Neeraja K.
Published: April 2019

In this paper author describing the concept of throughput and limited energy consumption while routing data to base station and will use multiple routes to forward data to base station. Wireless sensor networks (WSNs)remains resource constrict. Energy is one of the most essential resources in such networks. Hence, optimal use of energy is significant. In existing scheme sensor nodes are movable, base station is fixed and energy consumption is more. To overcome this, we are using the E2R2 protocol in which both sensor nodes & base station are mobile. The proposed protocol is hierarchical along with cluster based. All clusters contain one cluster head (CH) node, dual deputy CH nodes, also a few of ordinary sensor nodes. The reclustering time along with energy requirement has been decreases by introducing the concept of CH panel. All things Considered the reliability aspect of this protocol, it brings leading effort to provide a detailed throughput level by the BS. Topology of mobile wireless sensor networks with more no of nodes which is formed as clusters and transmission of packets between the sensor nodes is done to the base station [BS].Which is routed using E2R2 PROTOCOL, parameters such as throughput, energy spent. The simulation displays a certain proposed design successfully decreases the energy consumption among the nodes, and thus significantly improves the throughput compared to the existing protocol.
Blind's Mate - A Navigation System for Blind People
Authors: Mohod Dimpal , Meshram Pranalee , Bhelkar Sagarika , Padhye Shalaka , Kotangale Srushti , Deshmukh Prof. Rachana
Published: April 2019

Visually challenged people rely on companions around them on daily basis. Basic chores of day to day life pose a challenge for people with impaired vision. Walking on streets while dodging obstacles and navigating through roads to reach desired destination independently is one such challenge. Proposed system 'Blind's Mate' is a combination of software and hardware technology that can be used to improve the walking experience of blind people. Blind’s Mate is a combination of smart stick and a mobile app that can alert people of impending obstacles and water pits while providing audio feed to the users about obstacles encountered during walking. This stick is embedded with ultrasonic sensor to detect any obstacles in front of the user. The app gives live feed to the user continuously via earphones. Speech warning messages are activated when any obstacle is detected. The proposed stick is of low cost, has fast response, low power consumption, light weight and an effective means to help blind people finding their way on streets with ease.
Effect of Continuity and Smoothing of Profit on Corporate Profit- Stock Returns With Taking into Account the Heterogeneous Relationship of Profit - Efficiency on Companies Admitted to the Tehran Stock Exchange
Authors: Alinezhad Sarokolaei Mehdi , Tahmasbi Mehdi
Published: April 2019

The purpose of this study was to investigate the effect of continuity and smoothing of profits on the relationship between corporate profits - Stock efficiency taking into account the heterogeneous profit relationship – efficiency on companies admitted to the Tehran Stock Exchange, generally, profit has always been a factor in investor decisions. In this regard, on the one hand, accounting and stock returns are linked together, on the other hand, the variable of earnings quality is related to accounting profit and stock returns. So it may be that the question arises what is the effect of the continuity and smoothing of profits on the relationship between accounting profit and stock returns? The present research seeks to answer this question; as a result, the main question of the research is presented as follows: What is the effect of continuity and smoothing of earnings on the relationship between earnings and stock returns for listed companies in Tehran Stock Exchange? To check this, the data of 123 companies listed in Tehran Stock Exchange during the years 2012-2016 were used; data was analyzed using the Logit method using Eviews10 software. Evidence and empirical findings have shown that; both profit continuity and profit smoothing criteria have significant effects on the heterogeneous relationship between current period earnings and stock returns.
The changes in the Polish energy sector to reduce the pollutant emissions in the environment
Authors: Czajkowska Aleksandra
Published: April 2019

The Polish Energy Sector is one of the most difficult lines of business because among other things, of the existing legal provisions, and standards relating to pollutant emissions. In the coming years, in the Polish Energy Sector breakthrough changes related to develop the energy facilities and with respect to the environmental protection will have to be introduced. During the generation of electricity harmful residues are produced, which are counteracted by equipment designed for flue gas cleaning. The Energy Sector should be
concentrating on searching for the implementation of innovations to achieve emission standards.
ОРГАНІЗАЦІЯ ГОРИЗОНТАЛЬНОГО МОНІТОРИНГУ ЯК НОВОЇ МОДЕЛІ СПІВПРАЦІ ФІСКАЛЬНИХ ОРГАНІВ ТА ВЕЛИКОГО БІЗНЕСУ В УКРАЇНІ
Authors: Скоромцова Т. О.
Published: April 2019

Розглянуті концептуальні засади та перспективи запровадження нових форм податкових взаємовідносин великого бізнесу та фіскальних органів на основі запровадження нової моделі співпраці «горизонтальний моніторинг». Запропоновані основні напрями організації впровадження цього методу у вітчизняній податковій практиці. Визначені проблемні аспекти щодо повноцінного використання горизонтального моніторингу у фіскальних органах України.
Türkiye’de Akademik Enflasyon: “Her İle Bir Üniversite Politikası” Sonrasında Türk Yükseköğretim Sistemi
Authors: YALÇINTAŞ Altuğ , AKKAYA Büşra
Published: April 2019

Türk yükseköğrenim sistemi, 1980’li yıllardan bu yana uygulanan “her ile bir üniversite politikası”
(HİBÜP) ile birlikte, büyük bir dönüşüm sürecinin içerisine girmiştir. Bu çalışmada, HİBÜP’ün genel olarak
Türkiye ekonomisinde, özel olarak da yükseköğrenim sisteminde ölçülebilir ve kalıcı nitelikte bir iyileşmeye
yol açmadan, akademik enflasyon sorununa neden olduğunu ileri sürülmektedir. Akademik enflasyon, lisans
derecesine sahip mezunların, arzu ettikleri pozisyonlarda ve beklenti içine girdikleri göreceli yüksek ücret
seviyelerinde istihdam edilememesi durumudur. Bugün, birçok yazarın “genç işsizlik” adını verdiği yapısal
sorunun kaynağında, bilim ve teknoloji alanında politika yapıcıların, akademik enflasyona yol açan HİBÜP
konusundaki ısrarı yatmaktadır.
Student engagement at the beginning of vocational studies
Authors: Niittylahti Satu , Annala Johanna , Mäkinen Marita
Published: April 2019

This mixed-methods study examined student engagement at the beginning of vocational studies. The focus of the study was on students’ certainty about their career choices, how they experienced the social environment in vocational education and the relationship of these factors to student engagement. Firstly, 364 first-year students (aged 15–17) participated in the quantitative survey. Secondly, 17 students were selected for interviews. According to the results, student engagement at the beginning of vocational studies is related to overcoming uncertainty. In addition, students’ engagement and career choices are strengthened by the support and confirmation they receive, the students’ interest in their studies, their general abilities and their coping skills. Having friends at school diminished feelings of insecurity while co-operating with friends eased their sense of inadequacy. According to the results, teaching and the organisation of schooling may promote or hamper learning and active participation. Therefore, student engagement in vocational education seems to be strengthened through interactions with other students, friends and peers, and the teachers and other adults in the student’s life. This supports a more collective and collaborative view of engagement.