bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobility Digital Twin: Concept, Architecture, Case Study, and Future Challenges
Authors: Wang Ziran
Published: February 2022

A Digital Twin is a digital replica of a living or non-living physical entity, and this emerging technology attracted extensive attention from different industries during the past decade. Although a few Digital Twin studies have been conducted in the transportation domain very recently, there is no systematic research with a holistic framework connecting various mobility entities together. In this study, a Mobility Digital Twin (MDT) framework is developed, which is defined as an Artificial Intelligence (AI)-based data-driven cloud-edgedevice framework for mobility services. This MDT consists of three building blocks in the physical space (namely Human, Vehicle, and Traffic), and their associated Digital Twins in the digital space. An example cloud-edge architecture is built with AmazonWeb Services (AWS) to accommodate the proposed MDT framework and to fulfill its digital functionalities of storage, modeling, learning, simulation, and prediction. The effectiveness of the MDT framework is shown through the case study of three digital building blocks with their key micro-services: the Human Digital Twin with user management and driver type classification, the Vehicle Digital Twin with cloud-based Advanced Driver-Assistance Systems (ADAS), and the Traffic Digital Twin with traffic flow monitoring and variable speed limit.
Low Light Intensity and High Temperature Efficient Interdigitated Back- Surface-Contact Solar Cell with 28.81% Efficiency Rate
Authors: RAHMAN MD MAHFUZUR
Published: February 2022

Back-contact solar
cells improve optical properties by moving all electrically conducting parts to
the back of the cell. The cell's structure allows silicon solar cells to
surpass the 25% efficiency barrier and interdigitated solar cells are now the
most efficient. In this work, the fabrication of a light efficient and
temperature resistant interdigitated back contact (IBC) solar cell is
investigated. This form of solar cell differs from conventional solar cell in
that the electrodes are located at the back of the cell, eliminating the need
for grids on the top, allowing the full surface area of the cell to receive
sunlight, resulting in increased efficiency. In this project, we will use
SILVACO TCAD, an optoelectronic device simulator, to construct a very thin
solar cell with dimensions of 100x250μm in 2D Luminous. The influence of
sunlight intensity and atmospheric temperature on solar cell output power is
highly essential and it has been explored in this work. The cell's optimum
performance with 150um bulk thickness provides 28.81% efficiency with 87.68%
fill factor rate making it ultra-thin, flexible and resilient providing diverse
operational capabilities.
3kW Power Supply Design with Easy Manufacturability for 48 V Bus Power Architecture
Authors: Nabih Ahmed , Li Qiang
Published: February 2022

The increase of power requirements per server rack, especially in the 48V bus architecture is demanding the increase of rated power and power density per power supply to fit as many power supplies in the server rack power shelf as possible. Due to the trade-off between fabrication cost and efficiency (running cost) of the power supply, the design of efficient but yet less labor-intensive power supply is important. This paper discusses methods to design DC-DC unit of the 3kW power supply for the 48V architecture with easier manufacturability and lower cost. Prototype for 400V/48V 3kW 1MHz is demonstrated.
A Pipelined Algorithm and Area-Efficient Architecture for Serial Real-Valued FFT
Authors: HongJi Fang
Published: February 2022

In this brief, we present a novel pipelined architecture for real-valued fast Fourier transform (RFFT), which is dedicated to processing serial input data.

 An optimized algorithm of the stage division for RFFT is proposed to achieve an area-efficient RFFT computing structure with full hardware utilization.

 A single path butterfly (SBF) and a real rotator are merged into one processing element (PE) in each stage except the last stage to save latency and hardware resources.
DRS-LIP: Linear Inverted Pendulum Model for Legged Locomotion on Dynamic Rigid Surfaces
Authors: Iqbal Amir , Veer Sushant , Gu Yan
Published: February 2022

Legged robot locomotion on a dynamic rigid surface (i.e., a
rigid surface moving in the inertial frame) involves
complex full-order dynamics that is high-dimensional,
nonlinear, and time-varying. Towards deriving an
analytically tractable dynamic model, this study
theoretically extends the reduced-order linear inverted
pendulum (LIP) model from legged locomotion on a stationary
surface to locomotion on a dynamic rigid surface (DRS). The
resulting model is herein termed as DRS-LIP. Furthermore,
this study introduces an approximate analytical solution of
the proposed DRS-LIP that is computationally efficient with
high accuracy. To illustrate the practical uses of the
analytical results, they are used to develop a hierarchical
planning framework that efficiently generates physically
feasible trajectories for DRS locomotion.
The effectiveness of the proposed theoretical results and
motion planner is demonstrated both through simulations and
experimentally on a Laikago quadrupedal robot that walks on
a rocking treadmill.
Upaya Penanaman Pendidikan Karakter di Sekolah Dasar Telaah Pendekatan Struktural Fungsional Talcott Parsons
Authors: Sulistiawati Anjar , Nasution Khoirudin
Published: February 2022

Tujuan penelitian ini adalah untuk mengetahui upaya penanaman pendidikan karakter di sekolah dasar berdasarkan teori struktural fungsional Talcott Parsons. Pendekatan penelitian ini yaitu kualitatif deskriptif dengan metode observasi dan telaah literatur. Objek materil yaitu upaya penanaman pendidikan karakter di SD Negeri Trayu dengan objek formal pendekatan struktural fungsional Talcott Parsons. Analisis data yang digunakan adalah analisis sinkronisasi antara upaya penanaman pendidikan karakter dilapangan dengan teori struktural fungsional Talcott Parsons. Teori Talcott Parsons yaitu masyarakat sebagai suatu sistem saling berhubungan dan saling bergantung. Faktor terpenting dari suatu integrasi sistem sosial yaitu kesepakatan. Kemudian Talcott Parsons mengembangkan konsep imperatif fungsional untuk membuat sistem bertahan. Konsep imperatif ini biasanya disebut sebagai AGIL, yang merupakan singkatan dari Adaptation, Goal attainment, Integration, dan Latency. kesimpulannya bahwa penanaman pendidikan karakter di sekolah dalam hal ini dianalisis dengan pendekatan teori struktural fungsional Talcott Parsons melalui 4 tahap yaitu; tahap penetapan dengan tujuan penanaman pendidikan karakter goal attaintment, tahap adaptation sebagai proses adaptasi peserta didik dengan tata tertib dan kebiasaan di sekolah dalam  rangka mencapai tujuan pendidikan karakter, tahap integration penanaman pendidikan karakter dapat diintegrasikan dengan kegiatan intrakurikuler, ko-kurikuler, dan ekstrakurikuler. Kemudian pada tahap latency strategi penanaman pendidikan karakter harus dilaksanakan secara terus menerus atau berkesinambungan.
Persepsi Guru terhadap Pembelajaran Tatap Muka Terbatas di SD se-Gugus I Salawati Kabupaten Sorong
Authors: Widianingrum Risza Tri Fatmawati , Asrul Asrul , Irianti Mustika
Published: February 2022

Penelitian ini dilakukan dengan tujuan menganalisis Persepsi Guru Terhadap Pembelajaran Tatap Muka Terbatas Muatan IPA Pada Sekolah Dasar Gugus I Salawati Kabupaten Sorong. Penelitian ini menggunakan metode kualitataif, dengan pendekatan studi kasus. Teknik pengumpulan data yaitu observasi, wawancara dan studi dokumentasi. Subjek penelitian adalah guru kelas V di Gugus I Salawati Kabupaten Sorong. Analisis data yang digunakan dalam penelitian ini meliputi reduksi data, penyajian data dan kesimpulan atau verifikasi. Hasil penelitian menunjukkan bahwa persepsi guru terhadap pembelajaran tatap muka terbatas (PTMt), yaitu: 1. Kebijakan, pelaksanaan PTMt dapat dilaksanakan sesuai kebijakan pemerintah melalui SKB 4 menteri dan surat edaran bupati Sorong dengan sistem blok atau shieft. 2. Perencanaan, perencanaan PTMt disesuaikan dengan kondisi dan durasi yang sudah ditetapkan. 3. Pelaksanaan, cakupan materi dalam pelaksanaan PTMt terutama pada muatan IPA disampaikan sesederhana mungkin agar tidak memberatkan siswa. 4. Evaluasi, disesuaikan dengan kondisi yang ada serta dilakukan setelah peserta didik mengumpulkan tugas yang sudah diberikan baik itu teori maupun praktek. Kesimpulan dari penelitian ini bahwa PTMt lebih efektif dilakukan dimasa pandemi dibanding pembelajaran secara daring, kegiatan PTMt berlangsung normal meski ketersediaan waktu yang terbatas sesuai aturan pemeritah.
The Rhetorical Canons of Construction: New Textualism's Rhetoric Problem
Authors: Stewart Charlie
Published: February 2022

New Textualism is ascendant. Elevated to prominence by the late Justice Antonin Scalia and championed by others like Justice Neil Gorsuch, the method of interpretation occupies an increasingly dominant place in American jurisprudence. Yet, this Comment argues the proponents of New Textualism acted unfairly to reach this lofty perch. To reach this conclusion, this Comment develops and applies a framework to evaluate the rhetoric behind New Textualism: the rhetorical canons of construction. Through the rhetorical canons, this Comment demonstrates that proponents of New Textualism advance specious arguments, declare other methods illegitimate hypocritically, refuse to engage with the merits of their opponents’ arguments, and believe their method provides the best plain meaning.
Deformation of cylindrical parts mated with an axis during induction heating
Authors:   Dudin V.I. Lelehov S.A. Sushko A.V. Feschukov A.N.
Published: February 2022

In the paper, we consider separation of a metal cylinder hot or cold-pressed to the axis, when the separation is assisted with induction heating of details. The equations of thermal conduction and deformation were solved numerically, assuming all material properties are temperature depended, and magnetic susceptibility depends on the magnetic field as well. We compare the computed results with our experimental data.
Keywords: deformation, thermal conductance, induction heating, computer modelling, thermal contact resistance, numerical solution.
vladimir.dudin@gmail.com
Effectiveness of Project-Based Learning Models in Improving Students' Creativity (A Literature Review)
Authors: Cahyani Ni Ketut Cendy
Published: February 2022

The learning process on the 2013 curriculum uses a scientific approach that emphasizes students' activity in learning (student-centered learning). Learning that uses a scientific approach needs to be supported by the appropriate model and method. Project-based learning is one of the suggested learning models in the 2013 curriculum (K13). This learning model is designed to engage students in investigating real-world problems in their learning. Project-based learning drives teaching and learning, involves students in the learning process, motivates, and enhances the creativity of students. Hence, project-based learning is the appropriate learning model to improve students' creativity because it requires the students to be directly involved in their learning. Besides, students will also be more interested in learning because the problems used are related to their environment. Thus, the purpose of this paper is sharing the effectiveness of project-based learning model in improving students' creativity.
Effect of Visualized Reading Content on Students’ Reading Motivation
Authors: Darmayanti Ni Putu Era
Published: February 2022

The study was intended to explore the effect of visualized reading content on students’ reading motivation. This study was an experimental study. The present study was an experimental study with pretest-posttest design. This study was conducted in one junior high school in Singaraja and 32 students were involved. The result of analysis found that students reading motivation was better after the implementation of visualized reading content. Thus, it can be said that there is a significant mean difference between students in reading motivation before and after the implementation of visualized reading contents. Teachers are encouraged to implement visualized reading content in order to enhance students’ reading motivation.
THE ROLE OF HRM IN ENHANCING FINANCIAL INCLUSION IN INDIA BANKING SECTOR
Authors: Dr. Moath Mahmoud Alshar  , Dr. M. Sathya Shivalini
Published: February 2022

The main objective of current paper is identify the important roles of human resource management in enhancing the financial inclusion in Indian banking sector. The employees with reference to the roles of human resource management in Indian banking sector represented by the five banks is studied in this paper. The study population consisted of all employees in five Indian banks. A questionnaire was drafted and mailed to the one hundred and fifty employees randomly selected from the list of employees working for those banks. Fifty of the one hundred and fifty employees properly filled and the questionnaires and this is the main data source for my study. To achieve the objectives of the study, “to investigate into any relationship between Age, Gender and Educational level (demographic variable) of the employees and their impact on financial inclusion enhancement due to HRM roles” the researcher used descriptive analytical methods. The data was analyzed by employing One-way ANOVA test at 5% level of significance using SPSS statistical software. The result showed that, the Indian banks employees strongly conformed the roles of human resource management in enhancing financial inclusion.
KEYWORDS: Human Resource Management (HRM), Financial Inclusion, Indian banking sector.
Pengaruh Edukasi terhadap Pengetahuan Masyarkat Tentang Deteksi Dini Alzheimer di Kelurahan Labuh Baru Pekanbaru
Authors: Angga Arfina
Published: February 2022

Penyakit alzheimer merupakan salah satu penyakit gangguan pada otak bersifat ireversibel yang menyebabkan gangguan memori, keterampilan berpikir dan perubahan perilaku. Deteksi dan diagnosis yang dilakukan lebih awal pada penyakit alzheimer akan memberikan manfaat yang membantu individu dan keluarga penderita. Edukasi berperan membantu masyarakat untuk meningkatkan pengetahuan tentang deteksi dini penyakit alzheimer. Penelitian ini bertujuan mengetahui pengaruh edukasi terhadap pengetahuan masyarakat tentang deteksi dini alzheimer di Kelurahan Labuh Baru Kota Pekanbaru. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan desain quasi eksperiment pre and post test without control. Sampel penelitian adalah masyarakat yang berjumlah 30 orang dengan teknik consecutive sampling. Pengumpulan data dilakukan dengan kuesioner pengetahuan deteksi dini alzheimer. Data dianalisis menggunakan statistik uji T dependen.  Hasil penelitian menunjukkan ada peningkatan pengetahuan deteksi dini alzheimer yaitu dari rata-rata 5.733 sebelum edukasi menjadi 6.633 sesudah diberikan edukasi. Hasil uji T diperoleh nilai mean 0.900 dengan standar deviasi 1.241 dan p value 0,000 artinya ada perbedaan yang signifikan pengetahuan masyarakat tentang deteksi dini alzheimer antara sebelum dan sesudah pemberian edukasi. Edukasi dapat meningkatkan pengetahuan masyarakat tentang deteksi dini dari penyakit alzheimer dan secara lebih efektif diharapkan mampu mencegah komplikasi yang dapat muncul.
Efektivitas Blackgarlic Dalam Menurunkan Tekanan Darah Pasien Hipertensi di Puskesmas Simpang Tiga
Authors: Harahap Afrida , Siska Mulyani  , Siti Hafsyah Wahyuni
Published: February 2022

Hipertensi menjadi penyebab kematian dengan angka 23,7% dari total 1,7 juta kematian di Indonesia. Pencegahan  hipertensi  bisa diatasi dengan pengobatan Non Farmakologis yang salah satunya menggunakan  Black garlic. Black garlic adalah produk bawang putih yang telah difermentasikan dalam jangka waktu tertentu pada suhu dan kelembapan tinggi. Jenis penelitian ini adalah kuantitatif yang menggunakan desain Quasy Eksperimen dengan pendekatan one group pretest- postest. Penelitian ini  dilakukan  di  wilayah  kerja Puskesmas Simpang Tiga Pekanbaru. Populasi pada penelitian ini adalah seluruh pasien hipertensi diwilayah kerja Puskesmas Simpang Tiga Pekanbaru sebanyak 3.303 kasus. Pengambilan sampel menggunakan metode Accidental sampling sebanyak 15 orang penderita hipertensi. Hasil penelitian di dapatkan  rata-rata tekanan darah responden setelah mengkonsumsi  black garlic turun, yang bisa dilihat dari nilai mean pretest dan posttest sistolik yaitu 152,40   turun menjadi 129,66, dan nilai mean pretest dan posttest diastolik juga turun yaitu dari 95,00 menjadi 82,46 dan nilai P-value 0,000. Black garlic efektif  terhadap penurunan tekanan darah (sistolik dan diastolik) sebelum dan sesudah diberikan intervensi.
Confiabilidad del WHOQOL-BREF en estudios realizados en mujeres con cáncer de mama: revisión integrativa
Authors: Martín del campo- Navarro Valeria , Orellana-Yañez Alda , Moreno- González María Mercedes
Published: February 2022

Introducción: La calidad de vida en mujeres con cáncer de mama por su compleja multidimensionalidad ha requerido ser medida con cuestionarios tanto específicos como genéricos. Objetivo: Conocer la confiabilidad del cuestionario Calidad de Vida de la Organización Mundial de la Salud en estudios realizados en mujeres con cáncer de mama. Metodología: Revisión integrativa de artículos originales, en bases de datos PubMed, SciELO, Biblioteca Virtual en Salud, Web Of Science, con los descriptores Breast neoplasms, Calidad de Vida de la OMS, en conjugación con el boleano AND, se incluyeron artículos que mostraron confiabilidad del cuestionario Calidad de Vida de la Organización Mundial de la Salud, aplicado a mujeres con cáncer de mama, gratuitos en la web, texto completo, en idioma inglés, portugués o español, publicados entre 2009 y 2019. Se excluyeron estudios en mujeres con cáncer de mama con patología agregada. Se obtuvo muestra de 8 artículos. Resultados: Un 37.5%  de los estudios analizaron alfa de Cronbach global en rangos entre 0.72 a 0.84 con media de α=0.79. Los artículos que realizaron los dominios reportaron confiabilidad media en salud física 0.77, salud psicológica 0.77, relaciones sociales 0.76 y medio ambiente 0.72, demostrando confiabilidad apropiada. Conclusión: La confiabilidad a través del alfa de Cronbach para los dominios del cuestionario calidad de vida no difiere en función a la etapa del proceso de la enfermedad, lo que indica la pertinencia del uso del cuestionario en mujeres con cáncer de mama.
Teoría de los cuidados de Kristen Swanson: revisión de literatura
Authors: Berstain-García Isabel , Álvarez-Aguirre Alicia , Huerta-Baltazar Mayra Itzel , Casique-Casique Leticia
Published: February 2022

Introducción: La disciplina de enfermería ha buscado a lo largo de los años fundamentar las intervenciones de su quehacer aplicando teorías propias de la disciplina, como la teoría de los cuidados, la cual proporciona la pauta trasladarla a las áreas de acción. Objetivo: Analizar la evidencia científica disponible sobre la aplicación de la teoría de los cuidados de Kristen Swanson en el quehacer de enfermería. Metodología: Revisión de la literatura que aborda la teoría de los cuidados, se utilizó la metodología de Cooper, se consultaron diferentes bases de datos: IMBIOMED, CUIDEN, ScienceDirect, Fundación Index, MEDLINE, ciberINDEX, SciELO, Redalyc, entre otras. Los descriptores empleados fueron: enfermería, atención de enfermería, teoría de enfermería, en idioma español, inglés y portugués entre los años 2015 y 2019, se incluyó todo tipo de literatura, obteniendo una muestra de 42 artículos y disertaciones. Resultados: La mayoría de los documentos analizados no plasman por completo los procesos básicos de cuidado que plantea Swanson. La teoría ha demostrado ser útil en el área asistencial, elaboración de programas de intervención con neonatos, pacientes pos-operados de cardiopediatría, lactancia materna, cuidados en el puerperio y modificación de la actitud hacia la donación de órganos. Conclusión: La teoría se considera esencial para la valoración integral, adoptar sus fundamentos y conceptos es de gran utilidad, ya que favorece la generación de un primer espacio de aprendizaje, resulta útil para brindar un acompañamiento al paciente y su familia, y ofrecerles estrategias de mejora. Se requiere realizar más investigaciones de intervención, cualitativas y de docencia.
Methods applied by Russia to forecast the influence on other countries
Authors: Słowik Jakub
Published: February 2022

Objectives

The purpose of this article is to identify the quantitative and qualitative methods applied by Russia in planning exerting influence on other countries, including members of the Visegrád Group.

Methods

The research method used in this study consists in a systematic review of Russian and global political literature, as well as military literature, publications in the field of international relations, international politics, econometrics and forecasting, economy and management, in the aspect of the differences between the methods of forecasting the influence on other countries with respect to the methods described in international subject literature.

Results

The conducted analysis of documents enabled the identification and drawing the characteristics of the strategic forecasting methods that Russia may apply to influence other countries. The study also identifies the institutions as well as researchers who deal with the issues related to forecasting influence on specific countries in Russia.

Conclusions

Both the identified methods and the research centres focus on ensuring the effectiveness of Russian foreign policy that requires an accurate assessment of the current situation as well as detailed forecasts of potential events (scenarios) in the future. The method that deserves particular attention is the strategic matrix method, which has probably been modified, but its essential elements are still functioning.
NUMERICAL DESIGN OF STEERABLE GUIDEWIRES
Authors:   , Salunkhe Onkar Prakash
Published: February 2022

Biomedical devices are an integral part of the medical industry nowadays. With the increase in cases of heart disease, catheterization procedures are becoming more frequent. Small-scale actuators are needed for the guidance of small-scale catheters and guidewires to remote targets in the human body. Numerical modelling is needed to guide the experiments in developing such steerable devices and to optimize their design. Here, we designed small-scale steerable guidewires by first developing bending actuators and then assembling them with guidewires. The actuators use materials with strain response to electric potential in a very low voltage range that is not harmful to the human body. Our work examined the layered strip configuration for the structure of actuators and identified trends to maximize the bending deformations. Using the commercial software Abaqus, we developed a finite element model based on Piezoelectric actuation to simulate various combinations of materials and geometries and to optimize the design of the actuator and the steerable guidewires. We also developed an analytical model for the actuators and showed that the simulation results are in agreement with the analytical model. Parameters like thickness, length, and different geometrical combinations and their effect on bending were compared. This numerical model can be customized for different materials that can be used for designing these actuators in future.
Reporte de un caso de infección urinaria por kocuria varians
Authors: Benites-Azabache Juan Carlos , Ayala-Burga Zoila Victoria , Málaga-Díaz Jesús Eduardo
Published: February 2022

El género Kocuria es un microorganismo que forma parte de la microbiota de la piel y mucosas del hombre y algunos mamíferos. No es considerado como un patógeno primario, aunque ocasionalmente se han registrado reportes de infecciones en pacientes con compromiso de la inmunidad o tras procedimientos invasivos. En nuestro medio no hay evidencia de infecciones producidas por miembros de este género en sujetos sin compromiso de la inmunidad. Presentamos el caso de una paciente sin antecedentes de alteraciones del sistema inmune y no expuesta a procedimientos invasivos, quien presentó una infección urinaria por Kocuria varians.
Conflicto y multiculturalidad de los pueblos indígenas: análisis del caso de la Comunidad Nativa Tres Islas
Authors: Gonzáles Jorge
Published: February 2022

La presente investigación analiza el caso de la comunidad nativa Tres Islas, ubicada en la región de Madre de Dios, Perú. La comunidad decide proteger su territorio del daño ambiental, ocasionado por la extracción de recursos que realizan las empresas Los Mineros SAC y Los Pioneros SCRL. Las empresas elevaron su reclamo a las autoridades judiciales alegando el derecho al libre tránsito. El Poder Judicial, en primera y en segunda instancia, les dio la razón, ordenando el desahucio de la caseta de control de tránsito que había construido la comunidad para proteger sus tierras; por tanto, la comunidad decide llevar el litigio al Tribunal Constitucional. La finalidad del trabajo consiste en analizar los hechos y derechos conculcados a la comunidad nativa Tres Islas desde la mirada de los derechos humanos, la problemática de la multiculturalidad y los conceptos de educación intercultural y cultura de paz. Estos ejes permitirán traducir una realidad latente donde se evidencia la exclusión de los indígenas de los ámbitos sociojurídicos; lamentablemente, solo se respetan los parámetros culturales impuestos por Occidente, desconociendo las otras cosmovisiones.
Aponecrosis de la corteza piriforme en ratas albinas sometidas a administración crónica de bebidas alcohólicas adulteradas
Authors: Díaz Rudas José Rafael
Published: February 2022

En nuestro país, el alcoholismo es un problema de salud pública por la alta morbi-mortalidad que produce. Las bebidas alcohólicas que se consumen son diversas, y existe preferencia por las bebidas alcohólicas adulteradas en las zonas urbanomarginales. Para esta investigación se utilizaron 60 ratas albinas, Rattus norvegicus, cepa Holtzman, de 8 semanas de edad y de sexo masculino; las que fueron distribuidas en 5 grupos de 12 y recibieron una dosis diaria de 5,06 gramos de etanol/kg de peso corporal. Se emplearon las bebidas alcohólicas conocidas como “Tumbaloco” o pac: partes iguales de pisco, anisado y cognac (todos adulterados); “Penal” o pac+c: partes iguales de pisco, anisado y cognac (todos adulterados) + cerveza; “Pisco”: pisco autorizado; “Pisco + Cerveza”: pisco autorizado + cerveza autorizada. Luego de 12 semanas, las ratas albinas fueron sacrificadas por el método de decapitación, se les extrajo el encéfalo y se fijó en formol al 10 % tamponado a 4 °C por 7 días. Se realizó un corte coronal a nivel Bregma +3 mm para estudiar la corteza piriforme utilizando la coloración Hematoxilina & Eosina. En la corteza piriforme se encontró mayor densidad neuronal aponecrótica en los grupos experimentales, a predominio del grupo Pisco, en comparación al grupo blanco. Ello sugiere la presencia de algún compuesto químico presente en esta bebida y ausente en las otras bebidas alcohólicas adulteradas. Concluimos que la bebida alcohólica cuyo consumo crónico produce una mayor densidad neuronal aponecrótica en la corteza piriforme es el pisco de venta autorizada más barato del mercado. La añadidura de cerveza en las bebidas alcohólicas adulteradas no aumenta ni disminuye la aponecrosis neuronal.
Densidad oligodendroglial en nervio óptico murino por consumo crónico de metanol
Authors: Díaz-Rudas José Rafael , Hernández Palmer , Rivera María de los Ángeles
Published: February 2022

La mayoría de bebidas alcohólicas que se consumen en el Perú no cuentan con un registro sanitario; además, presentan componentes diferentes de los previstos en la norma. La adulteración de estas bebidas alcohólicas se evidencia en los niveles altos de etanol y bajos de metanol. El consumo agudo de concentraciones altas de metanol produce daño del nervio óptico y disminución de mielina y oligodendrocitos. El objetivo del estudio fue determinar el efecto del consumo crónico de concentraciones bajas de metanol en los oligodendrocitos del nervio óptico. Se utilizaron 60 ratas albinas macho, Rattus norvegicus, cepa Holtzman, edad 8 semanas. Fueron distribuidas aleatoriamente en 5 grupos de 12 ratas albinas cada uno: 1 grupo blanco y 4 grupos experimentales. Se utilizaron bebidas alcohólicas adulteradas: pisco (p), anisado (a) y cognac (c), y bebidas alcohólicas autorizadas: Pisco (P) y Cerveza (C) para elaborar los preparados alcohólicos correspondientes (grupos experimentales): pac, pac+C, Pisco y Pisco+C. La concentración de metanol en las bebidas alcohólicas adulteradas fue de 14,1 mg/100 ml (valor límite 150 mg/100 ml para bebidas destiladas según la Norma Técnica Peruana–Indecopi). El grupo blanco recibió agua ad libitum, y los grupos experimentales, una dosis diaria de 5,06 gramos de etanol/kg de peso corporal por sonda orogástrica. Luego de 12 semanas las ratas albinas fueron sacrificadas por corte medular a nivel cervical; se extrajo y fijó el nervio óptico en formol neutro al 10 %. Posteriormente, se realizó un corte transversal a nivel proximal del nervio óptico y se procedió al estudio histopatológico de los oligodendrocitos, axón y mielina con la coloración de Hematoxilina & Eosina. Se estudió la densidad oligodendroglial con el método estereológico del point counting, no encontrándose una diferencia significativa entre los 5 grupos mediante la prueba HDS Tukey (p=0,290). No existió variación en la densidad oligodendroglial. Se concluye que el consumo crónico de metanol a bajas concentraciones no produce alteración en la densidad oligodendroglial.
Determinación de intervalos de referencia de hemoglobina y hematocrito en una población de estudiantes de entre 18 y 25 años de ambos sexos de Lima, de acuerdo al método no paramétrico recomendado por el Clinical and Laboratory Standars Institute (CLSI)
Authors: Mengolé Amaya Pedro
Published: February 2022

El objetivo del presente trabajo consiste en determinar los intervalos de referencia para hemoglobina y hematocrito en una población adulta-joven del departamento de Lima. Se siguieron los lineamientos de la guía C 28-A3 del CLSI, para lo cual se eligió como población de referencia a estudiantes de una institución de educación superior que superaron los criterios de exclusión fijados y accedieron a la extracción de sangre. Fueron tomadas muestras de 120 varones y 120 mujeres. Los analitos se determinaron por el método de cianmetahemoglobina y microcentrifugación, siguiendo procedimientos estandarizados en las guías CLSI H 15-A3 y H 07-A3 respectivamente. El intervalo de referencia se calculó por el método no paramétrico descrito en la guía CLSI EP 38-A3. Los límites obtenidos fueron: hemoglobina= 14-16.8 g/dl (hombres), 11.3-14.3 g/dl (mujeres) y hematocrito= 41-53 % (hombres), 37-47 % (mujeres). Estos resultados fueron comparados con otros valores obtenidos en diferentes estudios.
Effects of antioxidant use on semen storage in honey bees
Authors: ÖZKÖK Arda Onur , YALÇIN Burcu
Published: February 2022

Although there are many studies for the storage of semen in honey bees, the desired success has not been achieved, and more study is needed in this area. It has been reported that the percentage of bee egg-laying in queen bees fertilized with stored semen, especially in long-term storage conditions is below the expected rate despite the viability rate. The reason for this situation is that honey bee spermatozoa are negatively affected by freezing processes due to their very fragile and sensitive structure. However, due to natural mating, honey bee semen can remain healthy for years in the queen bee's spermatheca. It is known that there are many enzymatic antioxidants and special proteins in the spermatheca, as well as a suitable environment for spermatozoa. Manipulating made during the stored of honey bee semen has adverse effects on spermatozoon function and fertility. In particular, current antioxidant substances against cold shock, which are among the damages that occur during freezing of semen, are being investigated, and their protective effects on semen are determined. For this purpose, it is aimed to improve the storage conditions of honey bee semen by using substances with antioxidant properties. The purpose of this review is to give information about the use of antioxidant substances in the storage of honey bee semen.
Ung thư biểu mô tuyến dạng gan nguyên phát tại phổi
Authors: Nguyen Thi Khuyen
Published: February 2022

TÓM TẮT

Ung thư biểu mô tuyến dạng gan của phổi (Hepatoid adenocarcinoma of lung - HAL) rất hiếm gặp, được định nghĩa là một khối u nguyên phát tại phổi sản xuất alpha - fetoprotein (AFP) - một loại protein được sản xuất chủ yếu ở gan và không có trong phổi. Hình ảnh mô bệnh học của HAL cũng gợi đến ung thư biểu mô tế bào gan (Hepatocellular carcinoma - HCC) khi di căn đến phổi. Ở đây, chúng tôi báo cáo một trường hợp bệnh nhân nam, 56 tuổi, có khối u ở phổi với chẩn đoán mô bệnh học và hóa mô miễn dịch là ung thư biểu mô tuyến dạng gan nguyên phát tại phổi. Bệnh nhân không tìm thấy tổn thương tại các cơ quan khác. Trường hợp này cho thấy chẩn đoán HAL là một thách thức, đòi hỏi chẩn đoán phân biệt HAL với HCC di căn tới phổi.

ABSTRACT

PRIMARY PULMONARY HEPATOID ADENOCARCINOMA

Primary hepatoid adenocarcinoma of the lung (HAL) is a rare type of adenocarcinoma, which can be defined as a primary alpha - fetoprotein - producing lung tumor. Histology of HAL resembles typical hepatocellular carcinoma (HCC) when it is metastatic to the lung. Herein, we report a case of a 56 - year - old male who was a lung mass with pathologically diagnosed as primary pulmonary hepatoid adenocarcinoma. No other lesions were found. This case shows the diagnosis of HAL is a challenge, requiring differentiation of metastasis HCC.

Key words: Hepatoid adenocarcinoma, lung.
U nguyên bào thần kinh nguy cơ cao bị tổn thương thận cấp và hội chứng bệnh lý não sau có hồi phục do cisplatin
Authors: Nguyen Thi Thanh Thuy
Published: February 2022

TÓM TẮT

Đặt vấn đề: Cisplatin là một trong những hóa chất được sử dụng nhiều trong điều trị bệnh lý ác tính ở trẻ em. Tuy nhiên đã có nhiều ghi nhận về tác dụng không mong muốn của Cisplatin. Báo cáo một ca bệnh điều trị Cisplatin có tổn thương thận cấp và hội chứng bệnh lý não sau có hồi phục.

Trường hợp bệnh: Trẻ nam 6 tuổi được chẩn đoán u nguyên bào thần kinh sau phúc mạc giai đoạn 4, nguy cơ cao và điều trị theo phác đồ Rapid COJEC. Từ ngày thứ 48 của liệu trình hóa chất, sau 2 đợt điều trị Cisplatin, trẻ có biến chứng tăng huyết áp và tổn thương thận cấp. Sau 3 đợt điều trị Cisplatin, ngày thứ 60 trẻ xuất hiện đau đầu, co giật cục bộ và mất ý thức ngắn. Chụp MRI sọ não có tổn thương lan tỏa vỏ và chất trắng dưới vỏ thùy đỉnh - chẩm và thái dương hai bên, tăng tín hiệu trên xung FLAIR, hình ảnh phù hợp vớihội chứng bệnh lý não sau có hồi phục. Sau điều trị 40 ngày bằng cân bằng nước - điện giải, chế độ ăn cho bệnh nhân suy thận, thuốc hạ áp, chống co giật, tình trạng trẻ được cải thiện. Trẻ không xuất hiện thêm co giật, huyết áp được kiểm soát. Chức năng thận trở về gần bình thườngvà MRI sọ não không còn tổn thương.

Kết luận: Bác sĩ ung thư nhi cần phát hiện kịp thời các tác dụng không mong muốn trong quá trình điều trị Cisplatin để xử lý và thay đổi thuốc điều trị phù hợp. ABSTRACT

CISPLATIN - INDUCED ACUTE KIDNEY INJURY AND POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME IN A CHILD WITH HIGH - RISK NEUROBLASTOMA

Background: Cisplatin is a widely used potent chemotherapy agent in the treatments of various malignant tumors in children. However, Cisplatin is reported to have several side effects. A case treated with Cisplatin and having acute kidney injury and posterior reversible encephalopathy syndrome was observed.

Case report: A case of a 6 - years - old boy was diagnosed retroperitoneal neuroblastoma stage 4 and was treated with Rapid COJEC regimen. On day 48, after 2 cycles of chemotherapy using Cisplatin, our patient developed hypertension and acute kidney injury. After 3 cycles of Cisplatin, on day 60, he had headache, focal seizure, and transient loss of consciousness. Brain MRI scan revealed edema in the cortical gray and subcortical white matter of the bilateral occipital, parietal and temporal lobes which were hyperintense only on FLAIR images, consistent with posterior reversible encephalopathy syndrome. After 40 days of treatment with fluid and electrolyte balance, renal diet, antihypertensive and anticonvulsant drugs, our patient’s condition has improved. He hasn’t had anyfurther seizure episodes. Blood pressure has been controlled and kidney function has returned to almost normal. His brain MRI showed complete resolution.

Conclusion: Pediatrician oncologists need to promptly detectany side effects while using Cisplatin to manage and switch to other drugs.

Keywords: Posterior reversible encephalopathy syndrome, acute kidney injury, Cisplatin.
Đánh giá kết quả điều trị ung thư đại trực tràng di căn gan bằng hóa chất phối hợp đốt sóng cao tần tại Bệnh viện K
Authors: Tran Thang
Published: February 2022

TÓM TẮT

Mục tiêu: Đánh giá kết quả điều trị UTĐTT di căn gan không còn chỉ định phẫu thuật triệt căn bằng hóa chất phối hợp đốt nhiệt sóng cao tần tại bệnh viện K.

Phương pháp: Gồm 30 bệnh nhân UTĐTT di căn gan, được được điều trị ĐNSCTkết hợp với hóa chất tại Bệnh viện K từ tháng 1/2017 đến tháng 8/2020.

Kết quả: Tỷ lệ đáp ứng hóa chất sau 4 và 8 chu kỳ lần lượt là 73,3% và 85,2%. 100% các bệnh nhân có đáp ứng khối u sau đốt nhiệt sóng cao tần trong đó đáp ứng hoàn toàn 63,3% và đáp ứng một phần là 36,7% theo tiêu chuẩn của hội điện quang can thiệp quốc tế. Thời gian sống thêm không tiến triển là 16,7 ± 1,42 tháng. Sau ĐNSCT: tất cả các bệnh nhân có đau vùng gan ở mức độ nhẹ và trung bình, 10% bệnh nhân có sốt, tăng men gan gặp ở 90% bệnh nhân.

Kết luận: ĐNSCT kết hợp hóa chất toàn thân là phương pháp an toàn và có hiệu quả trong điều trị ung thư đại trực tràng di căn gan không còn chỉ định phẫu thuật.

ABSTRACT

OUTCOMES OF COLORECTAL CANCER WITH LIVER METASTASIS TREATED BY RADIOFREQUENCY ABLATION PLUS SYSTEMIC CHEMOTHERAPYAT K HOSPITAL

Purpose: In this study, we evaluated the effectiveness of radiofrequency ablation with systemic chemotherapy in the treatment of colorectal cancer with liver metastasis at K hospital.

Methods: 30 patients with colorectal cancer liver metastasisin K hospital were retrospectively evaluated the effectiveness of radiofrequency ablation with systemic chemotherapy from January 2017 to August 2020.

Results: The responserate after 4 cycles and 8 cycles of chemotherapy was 73.3% and 85.2%, respectively. 100% of the patients had a tumor response after radiofrequency ablation. A complete response was 63.3%, and a partial response was 36.7% according to the International Intervention Photovoltaic Society standards. The progression - free survival was 16.7 ± 1.42 months. After radiofrequency ablation: all patients with mild to moderate hepatic pain, 10% of patients have fever, increased liver enzymes encountered in 90% of patients.

Conclusion: Radiofrequency ablation combination with systemic chemotherapy was safe; it showed efficacy in patients with liver metastasis after surgery for colorectal cancer and can be a preferred treatment.

Keywords: Colorectal cancer, chemotherapy, radiofrequency ablation.
CO-CREATING CREATIVE SELF-EFFICACY TO BUILD CREATIVE PERFORMANCE AND INNOVATION CAPABILITY FOR BUSINESS SUCCESS: A META-ANALYSIS
Authors: Yodchai Natthawut , Ly Pham Thi Minh , Tran Lobel Trong Thuy
Published: February 2022

Although creativity is considered a key driver of successful business, few studies examine it in a form of creative mindset. By means of a meta-analysis of 58 studies (n = 22,427), this study explores how creative mindsets and creative self-efficacy engage in affecting creative performance and innovation capability that result in business success. The results suggested that a growth mindset is positively related to creative self-efficacy, which can influence creative performance and innovation capability while a fixed mindset has negative effects. More importantly, creative performance contributes more to business success than innovation capability does. Thus, these results established the role of creative mindsets in enhancing business success. Therefore, this study provides scholars and practitioners the necessary evidence for making statistical inferences on creativity-based model and enhancing the business success.
OIL PRICE VOLATILITY AND AIRLINES’ STOCK RETURNS: EVIDENCE FROM THE GLOBAL AVIATION INDUSTRY
Authors: Horobet Alexandra , Zlatea Marinela Luminita Emanuela , Belascu Lucian , Dumitrescu Dan Gabriel
Published: February 2022

The paper explores the long versus short-term attributes of the airline industry exposure to oil price risk in a macroeconomic framework that emphasizes the interconnections between various risk factors, which is the main contribution to the research in the field. A panel ARDL model and PMG estimator have been applied on monthly data between 2007 and 2020 to investigate the long-term equilibrium relationship between airline companies’ stock prices, oil price risk, financial market volatility, currency risk, inflation, and maturity risk. The negative impact of oil price risk on airlines’ stock prices is significant, robust, and pervasive, and is coupled with a concerning exposure to the US dollar currency risk. As another contribution, the paper analyses the prospects and challenges of the airline industry in dealing with oil price risk in the post-pandemic world. The results point towards the need of the airline industry to rethink its strategic decisions in the more uncertain and unpredictable post-pandemic world, requiring a more comprehensive approach of the complex and dynamic network of risk exposures and a reconsideration of hedging policies.
The Breakthrough Listen Search for Intelligent Life: Technosignature Search of Transiting TESS Targets of Interest
Authors: Franz Noah , Croft Steve , Siemion Andrew P. V. , Traas Raffy , Brzycki Bryan , Gajjar Vishal , Isaacson Howard , Lebofsky Matthew , MacMahon David H. E. , Price Danny C. , Sheikh Sofia Z. , DeMarines Julia , Drew Jamie , Worden S. Pete
Published: February 2022

The Breakthrough Listen (BL) Initiative, as part of its larger mission, is performing the most thorough technosignature search of nearby stars. Additionally, BL is collaborating with scientists working on NASA’s Transiting Exoplanet Survey Satellite (TESS) to examine TESS Targets of Interest (TOIs) for technosignatures. Here, we present a 1–11 GHz radio technosignature search of 61 TESS TOIs that were in transit during their BL observation at the Robert C. Byrd Green Bank Telescope. We performed a narrowband Doppler drift search with a minimum S/N threshold of 10 across a drift rate range of ±4 Hz s−1 with a resolution of 3 Hz. We removed radio frequency interference by comparing signals across cadences of target sources. After interference removal, there are no remaining events in our survey, and therefore no technosignature signals of interest detected in this work. This null result implies that at L, S, C, and X bands, fewer than 52%, 20%, 16%, and 15%, respectively, of TESS TOIs possess a transmitter with an equivalent isotropic radiated power greater than a few times 1014 W.
Resolving Two Distinct Thermal X-Ray Components in a Compound Solar Flare
Authors: Zhou 周 Zhenjun 振军 , Liu Rui , Sun Jianqing , Zhang Jie , Ding Mingde , Cheng Xin , Wang Yuming , Yu Xiaoyu , Liu Lijuan , Cui Jun
Published: February 2022

X-ray emission provides the most direct diagnostics of the energy release process in solar flares. Occasionally, a superhot X-ray source is found to be above hot flare loops of ∼10 MK temperature. While the origin of the superhot plasma is still elusive, it has conjured up an intriguing image of in situ plasma heating near the reconnection site high above the flare loops, in contrast to the conventional picture of chromospheric evaporation. Here we investigate an extremely long duration solar flare, in which EUV images show two distinct flare loop systems that appear successively along a Γ-shaped polarity inversion line (PIL). When both flare loop systems are present, the hard X-ray spectrum is found to be well fitted by combining a hot component (T

e
∼ 12 MK) and a superhot component (T

e
∼ 30 MK). Associated with a fast coronal mass ejection (CME), the superhot X-ray source is located at the top of the flare arcade that appears earlier, straddling and extending along the long “arm” of the Γ-shaped PIL. Associated with a slow CME, the hot X-ray source is located at the top of the flare arcade that appears later and sits astride the short “arm” of the Γ-shaped PIL. Aided by observations from a different viewing angle, we are able to verify that the superhot X-ray source is above the hot one in projection, but the two sources belong to different flare loop systems. Thus, this case study provides a stereoscopic observation explaining the coexistence of superhot and hot X-ray-emitting plasmas in solar flares.
Modeling the Spectral Energy Distributions and Spectropolarimetry of Blazars—Application to 4C+01.02 in 2016–2017*
Authors: Schutte Hester M. , Britto Richard J. , Böttcher Markus , van Soelen Brian , Marais Johannes P. , Kaur Amanpreet , Falcone Abraham D. , Buckley David A. H. , Rajoelimanana Andry F. , Cooper Justin
Published: February 2022

The optical radiation emitted by blazars contains contributions from synchrotron radiation by relativistic electrons in the jets, as well as thermal radiation emitted mainly by the accretion disk (AD), the broad-line region (BLR), and the host galaxy. The unpolarized radiation components from the AD, BLR, and host galaxy present themselves by decreasing the total polarization in the optical/ultraviolet (UV) spectrum. A combined model for the spectral energy distribution (SED) and degree of optical/UV polarization is constructed, enabling the disentanglement of the synchrotron and AD components. Our model is applied to the multiwavelength SED and spectropolarimetry observations of the flat-spectrum radio quasar 4C+01.02 (z = 2.1) in its 2016 July–August flaring state and 2017 July–August quiescent state, using data from the Fermi Large Area Telescope, the Southern African Large Telescope, and the Las Cumbres Observatory network of telescopes. By constraining the AD component, the mass of the supermassive black hole is obtained as ∼3 × 109
M
⊙. Furthermore, the model retrieves the characteristics of the relativistic electron distribution in the jet and the degree of ordering of the magnetic field. Our results highlight the potential of spectropolarimetry observations for disentangling thermal from nonthermal (jet) emission components, thus revealing the physics of particle acceleration and high-energy emission in active galactic nucleus jets.
Hα Dots: Direct-method Metal Abundances of Low-luminosity Star-forming Systems
Authors: Hirschauer Alec S. , Salzer John J. , Haurberg Nathalie , Gronwall Caryl , Janowiecki Steven
Published: February 2022

Utilizing low-luminosity star-forming systems discovered in the Hα Dots survey, we present spectroscopic observations undertaken using the Kitt Peak National Observatory 4 m telescope for 26 sources. With determinations of robust, “direct”-method metal abundances, we examine the properties of these dwarf systems, exploring their utility in characterizing starburst galaxies at low luminosities and stellar masses. We find that the Hα Dots survey provides an effective new avenue for identifying star-forming galaxies in these regimes. In addition, we examine abundance characteristics and metallicity scaling relations with these sources, highlighting a flattening of both the luminosity–metallicity (L–Z) and stellar mass–metallicity (M
*–Z) relation slopes in these regimes as compared with those utilizing samples covering wider respective dynamic ranges. These local, accessible analogs to the kinds of star-forming dwarfs common at high redshift will help shed light on the building blocks that assembled into the massive galaxies common today.