bluuebunny/crossref_metadata_2025 huggingface dataset:
Changing a Life in Medical Missions: Chronic Actinic Dermatitis
Authors:   Dermatology Training at KCU-GME Consortium/Orlando Dermatology Program, Orlando, USA, Mammino Jason , Mammino DO and Jere ,   Dermatology, KCU-GME Consortium/Orlando Dermatology Program, Program Director, Orlando, USA
Published: October 2024

A 47-year-old male was seen in a rural Nicaraguan community for difficulty shaving his beard. The patient stated his face changed roughly 10 years ago and since has never looked the same. He presented at the clinic with an eczematous rash confined to the sun exposed surfaces on his skin. His face and posterior neck were covered in a confluent lichenified erythematous eruption sparing only the forehead and eyelids. The upper chest, forearms, and dorsal hands were hyperpigmented with various hypertrophic and hyperkeratotic lesions. The diagnosis of chronic actinic dermatitis was made due to the overall clinical picture along with limitations in further diagnostic capabilities. After initial therapy, the patient ecstatically returned to the clinic with greatly improved skin.
Herbal Hair Serum: Design Development & Evaluation
Authors:   Six Sigma College of Pharmacy, Jafarpur-Dineshpur Road, Khanpur Purab, Rudrapur, Uttarakhand, India, kumar Arun
Published: October 2024

By Hair is an epidermal by-product that plays an important role in enhancing the overall beauty of the body. Dandruff, Hair fall, grey hair are few problems committed hair faced by people.
Investigation of Frailty, Dependence, Fall Risk Levels, and Influencing Factors in Elderly Individuals
Authors:   Yozgat Bozok University, Facult of Health Science, Department of Nursing. Yozgat, Turkey, KUŞ Betül
Published: October 2024

The fragility, dependency and fall risk levels of the elderly are quite high. Physiological changes brought about by aging may cause recurrent falls in elderly individuals, and their quality of life may be negatively affected due to falls. This study was planned to examine fragility, dependence, fall risk, levels of protective behavior against falling, and the affecting factors in the elderly. The cross-sectional, descriptive, and correlational study was carried out with 200 elderly individuals who were admitted to the osteoporosis outpatient clinic of a university hospital. Data collection was done through Elderly Individual Information Form developed by the researchers, the Edmonton Frail Scale, the Barthel Index, the Itaki Fall Risk Scale, and the Fall Behavioral Scale for Older People. The mean age of the elderly who participated in the study was 72.07±6.76 years, 79.5% of the participants were female, 68% were primary school graduates, and 93.0% were retirement pensioners. The mean score of Edmonton Frail Scale was 6.06±2.92, Barthel Index was 94.85±12.57, Itaki Fall Risk Scale was 9.85±0.31, and Fall Behavioral Scale for Older People was 2.89±0.46. Many socio-demographic and fall-related risk factors specific to elderly individuals had an effect on the related scale scores (p < 0.05). The elderly individuals were moderately frail, slightly dependent on others in performing their life activities, had a high risk of fall, and had moderate protective behavior against falls.
Teachers’ Perceptions on their Readiness to Teach HIV/AIDS Education in Schools
Authors:   South African Council of Educators (SACE), Crossway Office Park, Block 1, 240 Lenchen Avenue, Centurion 0157, South Africa, Ringisai Lovemore
Published: October 2024

South Africa is the highest HIV prevalence country in the world with young people (15-24 years) making up the largest proportion of HIV infected people. Kwazulu-Natal is the worst affected province nationally. Poor teacher training and the stigma around HIV/AIDS are contributing factors. Therefore an effective school-based HIV/AIDS education intervention program should encompass effective teacher training and curriculum development. A cross-sectional study was conducted among teachers to identify the factors that support or hinder their role in HIV/AIDS education. A self-administered questionnaire was used for interviewing teachers from stratified randomly-selected 2 primary and 2 secondary schools in the province of KwaZulu-Natal’s Pietermaritzburg region. Teachers from 2 out of the 4 selected schools were trained under an HIV/AIDS education intervention program funded by Community Care Project while those from the other 2 selected schools were not trained. This was meant to compare (using tables and graphs) the teachers’ perceptions, ability, skills, and their participation in HIV/AIDS education between the trained and untrained teachers. While about 56% of the untrained teachers never taught about HIV, it was only 5% of the trained teachers who never taught about HIV. While 97% (95% CI 93.85–100) of the trained teachers use interactive teaching methods, it was only 41% (95% CI 28.21-53.99) on the untrained teachers. Higher number of untrained teachers (70%) reported facing difficulty while talking about HIV issues compared to the trained teachers (9%). So trained teachers were more likely to participate, less likely to face difficulties, and more likely to use interactive teaching methods in HIV/AIDS classes compared to the untrained teachers. Inadequate time allocation to HIV/AIDS classes was found to be a barrier to HIV/AIDS education. This suggests the need to provide teachers with more support in terms of training and logistics.
Effect of Awake Prone Position in Covid-19 Patients with MildModerate Symptoms to Reduce the Risk of Developing into Severe Cases : A Systematic Review
Authors:   Faculty of Nursing, Airlangga University, Surabaya, Indonesia, Yuswanto Andis
Published: October 2024

Introduction: The prone position is a method to increase ventilation in the breathing process. This study will carry out a systematic review of previous journals that discuss the impact of the awake prone position on corona virus disease-19 patients which can reduce the risk of developing into a severe case. Methods: A literature search was conducted in the last 5 years of research selected from several indexed electronic databases (Scopus, Science Direct, PubMed, Web of Science ). A total of 27 8 articles were obtained, and after being selected, 1 2 were found to be selected based on criteria and were a randomized control trial, Cohort Retrospective Study , case control. Results: 8 articles explaining that the awake prone position is effective in improving hypoxic conditions marked by increased oxygen saturation in the blood of corona virus disease-19 patients with mild-moderate symptoms. Conclusion: The awake prone position exercise is still the main choice for therapy in corona virus disease-19 patients with mild-moderate acute respiratory distress syndrome. Because it causes an increase in oxygenation and mechanical respiratory function in patients thereby reducing the risk of becoming a severe case.
A Technical Overview of the Pharmaceutical Development Process and Best Practices
Authors:   Senior Supply chain consultant, Rudra Technologies Inc, USA, Singhal Rohit
Published: October 2024

The pharmaceutical development process is the foundation for the production of safe, effective, and highquality medications. This article explores the complex stages of pharmaceutical development, starting with the significance of selecting appropriate drug substances and excipients, formulation development, and establishing robust manufacturing processes. The integration of Quality by Design (QbD) principles and advanced risk management strategies is discussed as a means to optimize development and ensure regulatory compliance. By adhering to the guidelines outlined by the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use considerations (ICH) guideline Q8 (R2) on pharmaceutical development, pharmaceutical companies can enhance product quality, reduce variability, and ensure the consistent delivery of therapeutic products to the market.
Link between Cognitive Abilities and Physical Activity: Cognitive Training in Physical Rehabilitation
Authors:   Department of Humanistic Studies, University of Foggia, Italy, Genzano Nadia
Published: October 2024

Patients in physical rehabilitation programs need to learn motor skills that they previously performed automatically. Therefore, understating learning processes involved in physical rehabilitation may be useful to implement rehabilitation programs in terms of achieved goals, recovery speed, and patient satisfaction.
Sports Injury Management
Authors:   MPT Orthopaedics, Assistant Professor, Department of Musculoskeletal, Sardar Patel University, Arthritis Clinic, Vallabh Vidyanagar, Gujarat, India, Soni Ektaben
Published: October 2024

Sports injuries are prevalent among athletes and can range from minor sprains and strains to severe fractures and ligament tears.
Inteligencia artificial en la investigación clínica y redacción de artículos científicos
Authors: Campos-Miño Santiago
Published: October 2024

En 1991, durante mi primer año de residencia, inicié el uso de un computador personal para la escritura de algunos documentos, entre ellos una revisión narrativa sobre talla baja, que se publicó en el Boletín de la Escuela de Medicina de la universidad en donde me formé1, y la presentación de un caso clínico de quilotórax, publicado en una revista chilena llamada “Pediatría al Día”2. Para entonces, el acceso al internet no era fácil, la conexión era física, mediante un cable, y la información debía cargarse en el computador mayormente mediante diskettes. En todo caso, el computador era muy útil, como lo sigue siendo hoy, para el desarrollo del texto, análisis de datos y preparación de tablas y figuras. La posterior adición de correctores de gramática y ortografía, hojas de cálculo, diseño de presentaciones y programas básicos de estadística, incrementó la inteligencia de los investigadores y ahora son herramientas de uso rutinario potenciadas con la conexión rápida e inalámbrica a internet.
Angioqueratoma en Síndrome de Klippel Trénaunay: Reporte de caso clínico
Authors: Barrera León Ricardo Germán , Vargas Domínguez Verónica Lissette , Pérez Guerrero Fernando Horacio
Published: October 2024

El síndrome Klippel-Trénaunay es una patología vascular poco frecuente congénita que se caracteriza por la observación de una tríada de malformaciones capilares cutáneas, varicosidades e hipertrofia de tejidos blandos y huesos largos, entre las malformaciones cutáneas poco frecuentes se encuentran los angioqueratomas los mismo que se presentan como una pápula de 2 a 10 mm de diámetro, generalmente de color rojo oscuro, a veces de azul a negro, cuya superficie es queratósica a la palpación, los mismos pueden suponer un reto terapéutico. Se presenta caso de paciente masculino de 13 años de edad con antecedentes clínico de síndrome de Klippel Trénaunay, que acude por presentar nodulaciones dolorosas a nivel inguinal de una semana de duración al examen físico múltiples pápulas queratósicas violáceas en escroto, muslo y rodilla izquierda, se realiza exeresis de piel de región inguinal derecha para realizar biopsia la misma compatible con angioqueratoma por lo cual se programó a terapia laser CO2 con mejoría del cuadro a la semana de control. Los angioqueratomas son entidades poco frecuentes en el síndrome Klippel-Trénaunay, las opciones de tratamiento tradicionales incluyen la escisión quirúrgica, la electrodesecación, la cauterización y la crioterapia. Sin embargo, la terapia de láser de dióxido de carbono (CO2) ha mostrado eficacia frente a este tipo de lesiones.
¿La enseñanza de la nutrición clínica en Ecuador es suficiente para enfrentar nuestra realidad?
Authors: Becerra Luis Miguel
Published: October 2024

El reciente artículo editorial publicado en la revista Metro Ciencia1 aborda una preocupación crítica sobre la suficiencia de la enseñanza de la nutrición clínica en Ecuador, en particular frente a la alarmante prevalencia de desnutrición crónica infantil revelada por la Encuesta Nacional sobre Desnutrición Infantil (ENDI). Es preocupante que, a pesar de los esfuerzos por medir y mitigar la desnutrición en el país, los conocimientos sobre nutrición entre los profesionales de la salud siguen siendo insuficientes.Desde 1986, varias encuestas han evaluado la situación nutricional de los niños menores de cinco años en Ecuador. Sin embargo, la ENDI de 2023 es la primera en centrarse exclusivamente en la desnutrición y sus determinantes. Los resultados son alarmantes: la desnutrición crónica afecta al 17,5% de los niños menores de cinco años y al 20,1% de los menores de dos años, siendo más prevalente en las áreas rurales de la Sierra. Estos datos son consistentes con las estadísticas previas, que ya mostraban una prevalencia preocupante de desnutrición infantil, sin mejoras significativas en las últimas dos décadas.
Nuevos avances en el cuidado perioperatorio del paciente con trasplante renal: aspectos relevantes
Authors: Bermúdez Moyano Stefanya Geraldine , Gil Gutiérrez Carlos Enrique , Rozo Canizales Luisa Fernanda , Serna Trejos Juan Santiago
Published: October 2024

El trasplante de órganos abdominales supone uno de los actos quirúrgicos con mayor auge en las últimas dos décadas, ofreciendo mayor expectativa de vida en pacientes con condiciones relacionadas a insuficiencia orgánica terminal. El desarrollo de la enfermedad renal crónica (ERC), supone un problema importante de salud pública, donde se han descrito en la literatura prevalencias medias de 7.2 % de los individuos mayores de 30 años, lo cual ha motivado el desarrollo de nuevas terapias dirigidas a objetivos en el caso de pacientes con enfermedad renal terminal1. En el caso del trasplante renal, se reserva para pacientes con ERC avanzada en etapa terminal, la cual es definida como aquella afectación sobre la filtración renal donde el filtrado glomerular se encuentre inferior a los 30ml/min/1,73m2, Otras indicaciones están correlacionadas con glomerulonefritis, pielonefritis, enfermedades hereditarias, metabolopatías, nefropatías postrenales, enfermedades del colágeno sistémicas, tumores, condiciones congénitas, entre otras2,3.
Caught in the Crossfire: Ecuador’s Safety Crisis Impact on Teen and Young Adult Mental Health
Authors: Vargas Ariel , Gallegos Camila , Moreno Kevin
Published: October 2024

Introduction: During the past decade, Ecuador has become one of the most dangerous countries in Latin America, with a significant rise in violence impacting mental health. This study investigates hospital admissions for mood disorders among adolescents and young adults in Ecuador from 2021 to 2022. Methods: We used public access data from the National Institute of Census and Statistics (INEC) to analyze hospital admissions for mood disorders in individuals aged 12 to 21, categorized using the International Classification of Diseases (ICD-10) codes F30 to F39. Results: Results show a female predominance in admissions, with a female-to-male ratio of 3:1 by 2022. Admissions for depressive episodes accounted for 66.5% of cases, peaking in 2022. The regions with the highest admission rates were the Galapagos Islands and Pichincha. A notable reduction in admissions was observed in 2020, likely due to the COVID-19 pandemic´s impact on healthcare access. Discussion: The study's findings highlight significant gender disparities, diagnostic trends and regional differences in mood disorder admissions. The increasing trend, particularly for depressive episodes, underscores the need for enhanced mental health resources. Conclusion: The study concludes that the escalation of violence in Ecuador significantly impacts mental health, emphasizing the urgency of addressing social determinants of health and focussing efforts on regions most affected by conflict.
Reconocimiento a médicos postgradistas de Ortopedia y Traumatología del Hospital Metropolitano
Authors: Santos B. Esteban
Published: October 2024

El pilar fundamental de una atención médica acorde con los mejores estándares de calidad a nivel mundial, lo constituye el nivel científico de sus médicos postgradistas, pues son el motor del conocimiento que impulsa a los servicios de especialidad al progreso y desarrollo.Son ya 25 las promociones de postgradistas en Ortopedia y Traumatología formados en nuestro Hospital Metropolitano y con certeza debemos señalar que al momento, la mayoría de ellos son los referentes en el país entero.
Gender Roles and their Influence on the Socio-economic Dynamics of the Community in Jamunar Char Under Manikganj District, Bangladesh
Authors: Hossain Abul , Amin Sardar Nurul , Kabir Humayun
Published: October 2024

This study explores the influence of gender roles on the socio-economic dynamics of Jamunar Char in the Manikganj District of Bangladesh, focusing on their impact on household decision-making and economic participation. The research aims to assess how gender roles shape decision-making processes within households, with a particular emphasis on women's involvement in agriculture, fisheries, and other livelihood sectors. The study examines the barriers and opportunities that affect women's participation in income-generating activities and entrepreneurship. This study uses a mixed-methods approach to explore how gender roles influence socio-economic dynamics in Jamunar Char, Bangladesh. Combining quantitative surveys and qualitative case studies, the research reveals gender-based disparities in economic activities, decision-making, and access to resources. Findings reveal how entrenched gender roles impact economic opportunities and decision-making in the community. This study highlights the critical need for gender-sensitive policies to enhance women's economic contributions and address the structural challenges they face. By identifying these barriers and opportunities, the research provides valuable insights for developing targeted interventions to promote gender equity and economic resilience in Jamunar Char.
PERCEPTION AND ATTITUDE OF IMO STATE ELECTORATE TOWARDS VOTE BUYING
Authors: Umoren Philomena Effiong , Oduenyi Chuddy Christian , Onyekachi Christian Emmanuel , Williams Etumnu Emeka , Vera Anukam , Queen C. Enwerem
Published: October 2024

Despite the potential consequences of vote purchasing on the nation's democratic system, vote-trading has become a common practice in Nigeria, where a deeply entrenched corrupt political class and a complex political environment have made it difficult for democracy to fully consolidate. The aim of this study was to evaluate the perception and attitude of Imo State electorate towards vote buying. The theoretical underpinning of this study was the social judgement theory. The methodology adopted for this investigation was the survey research design. From a population of 5,459,300, electorate who are eligible to vote in Imo State, a sample size of 384 was arrived at using Wimmer and Dominick online sample size calculator. Findings of this study revealed that respondents are highly aware of vote buying and this awareness has in no little way shaped their perception of the menace. Further findings also revealed that the attitude of Imo State electorates towards vote buying have been favourably influenced as a result of their high level of awareness of vote buying. This study therefore recommended that fighting vote buying must be a conscious effort of the government to provide infrastructure and amenities that will revive the hopes of its citizen towards good governance. Also, further study on vote buying should be carried out by other researchers to cover other regions this study could not handle.
UNVEILING FEMALE FORTITUDE IN CHAN LING YAP’S A FLASH OF WATER: A FLȂNEUSE’S PERSPECTIVE
Authors: Amran Nurul Atiqah
Published: October 2024

This study seeks to expand the established critical discussion regarding the presence of a flâneuse in the rapidly transforming Malaya during the flourishing days of the British Empire, as depicted in Chang Ling Yap’s work, A Flash of Water (2015). Earlier discourse has explored the term flâneuse in Yap’s fifth novel, positioning and making sense of her presence in the postcolonial Malaya modernity. Using flânerie as the method for literary analysis, Yap’s protagonist assumes a distinct position in her life compared to the characters in Baudelaire’s and Benjamin’s works. Shao Peng defies the image of a degraded heroine who needs sympathy and embodies the allure of the flâneuse persona, delineating it throughout her journeys to the city and public realms, and transitions while dealing with issues in the novel. The critical approach highlights her urban experiences and closely examines how she explores her public realms through walking and observing. Customs and traditions are dealt with from the perspective of a flâneuse, linking accounts from daily life to her social engagement within the culture of the spectacle. This study finds that she is also breaking free from the confined roles traditionally associated with a flâneuse.
EXPLORING VOCABULARY GROWTH THROUGH SONGS: AN IN-DEPTH INTERVIEW OF MALAYSIAN UNDERGRADUATE STUDENTS
Authors: Meganathan Pavani Malaa , Satyanarayana Shaila Devi , Arumugam Nalini
Published: October 2024

This study investigates the perceptions of Malaysian undergraduate students regarding the use of English songs as a tool for vocabulary acquisition. Through in-depth interviews with five undergraduate students in Malaysia, the study examines their experiences, insights, and reflections on utilising English songs to expand their vocabulary. Four prominent themes emerged from the analysis: subconscious word learning, learning of pronunciation and accent, vocabulary retention, and exposure to authentic English words. The results reveal that while listening to English songs undergraduate students in Malaysia improve their English language by learning new words, accent and improving pronunciation. Learners benefit from the autonomy to choose strategies they deem suitable for their learning, while also benefiting from teachers' guidance on various strategies to employ. The study concludes that there is a growing preference for engaging approaches such as using English songs, and providing students with an enjoyable and immersive way to learn vocabulary.
ANALYSING THE IMPLEMENTATION AND ACHIEVEMENT OF THE NATIONAL LANGUAGE SYLLABUS IN TAMIL PRIMARY SCHOOLS: A CASE STUDY OF UPSR RESULTS AND PROFICIENCY GAPS
Authors: Muthusamy Thirugnana Sambanthan , Soon Lee Kenny Cheah , Fong Peng Chew
Published: October 2024

The difficulties of using the National Language (NL) curriculum in Tamil primary schools in Malaysia are discussed in this paper. Although Tamil primary school pupils struggle with NL competence, hurting their secondary school preparation, the Malaysian educational system requires mastery of Bahasa Melayu, the National Language. The research uses 2019 UPSR data to examine the NL success levels in comprehension and writing among Tamil school children. Focusing on a sample of Tamil pupils, the approach used a quantitative study of test results from national-type schools. Data were gathered using UPSR Comprehension and Writing papers. The results showed a notable difference in NL proficiency as only 40.11% of pupils attained an acceptable level in both examinations. Important debates focused on the absence of NL exposure in everyday life and the effect of mother tongue interference as main contributing elements. According to the report, standardising the NL curriculum and enhancing it across the institutions would assist to reduce these disparities. This study highlights the necessity of strategic changes to promote Tamil primary school pupils' language competency, therefore guaranteeing better preparation for secondary education.
Cải tiến và tiêu chuẩn hoá quy trình lắp ráp xe Bus
Authors: Lê Viết Trung
Published: October 2024

Hiện nay, nhiều nhà khoa học đang tập trung nghiên cứu liên quan đến quy trình lắp ráp và quy trình kiểm tra chất lượng của các công đoạn sản xuất xe bus tại các nhà máy sản xuất. Trong đó, Có nhiều nghiên cứu tập trung vào lắp ráp xe bus. Nghiên cứu này tập trung vào việc đề xuất quy trình cải tiến và tiêu chuẩn hóa trong việc lắp ráp xe bus City thông qua việc áp dụng phần mềm Visual Components. Ứng dụng công nghệ mô phỏng để tối ưu hóa quy trình lắp ráp, bao gồm từ việc thiết kế quy trình cho đến sản xuất cuối cùng. Tác giả đề xuất một phương pháp hiệu quả và tiên tiến để tăng cường hiệu suất và chất lượng sản phẩm trong ngành công nghiệp sản xuất xe bus. Sử dụng phần mềm Visual Components không chỉ đảm bảo sự chính xác trong quy trình lắp ráp mà còn giảm thiểu thời gian và chi phí, đồng thời tạo ra một quy trình làm việc đồng bộ và dễ quản lý, có thể thay đổi nhanh nếu trong quá trình sản xuất phát sinh cải tiển làm mới sản phẩm, hoặc yêu cầu thay đổi từ khách hàng. Đây là một bước tiến quan trọng trong quá trình chuyển đổi số của các doanh nghiệp sản xuất và lắp ráp, mở ra cơ hội để nâng cao năng suất và cạnh tranh toàn cầu trong lĩnh vực sản xuất xe bus
Xây dựng phần mềm đánh giá độ tin cậy và an toàn của phương tiện đường sắt đô thị tuyến cát linh - hà đông trong quá trình khai thác
Authors: Nguyễn Đức Toàn , Đỗ Đức Tuấn
Published: October 2024

Hiện nay vấn đề đánh giá độ tin cậy và an toàn của hệ thống đường sắt đô thị trong điều kiện Việt Nam còn hoàn toàn mới mẻ, do đó cần được từng bước nghiên cứu và hoàn thiện. Để giải quyết vấn đề đặt ra, cần thiết lập mô hình đánh giá độ tin cậy và an toàn của phương tiện, sau đó xây dựng các chương trình hoặc phần mềm tính toán. Trên cơ sở mô hình đánh giá độ tin cậy và an toàn của phương tiện đường sắt đô thị đã được nhóm tác giả thiết lập, bài báo trình bày quá trình xây dựng phần mềm đánh giá độ tin cậy và an toàn của phương tiện đường sắt đô thị tuyến Cát Linh-Hà Đông trong quá trình khai thác. Phần mềm được xây dựng trên cơ sở ngôn ngữ lập trình Java với nhiều chức năng tùy biến, có giao diện thuần Việt, cho phép đánh giá độ tin cậy và an toàn của phương tiện đường sắt đô thị tuyến Cát Linh-Hà Đông một cách thuận lợi, nhanh chóng và chính xác. Đây là phần mềm lần đầu tiên được xây dựng ở Việt Nam trong lĩnh vực phương tiện đường sắt đô thị, là cơ sở tham khảo cho việc xây dựng phần mềm đánh giá cho các đối tượng khác của tuyến Cát Linh-Hà Đông nói riêng và các tuyến đường sắt đô thị ở Việt Nam nói chung
Phân tích ứng xử của kết cấu áo đường mềm xét đến ảnh hưởng của sự thay đổi nhiệt độ theo chiều sâu các lớp mặt đường bê tông nhựa
Authors: Nguyễn Văn Hùng , Bùi Văn Phú , Trần Danh Hợi , Nguyễn Quang Tuấn
Published: October 2024

Mô đun động và hệ số Poát xông động của các lớp bê tông nhựa (BTN) và cấp phối đá chặt gia cố nhựa nóng (ĐGCN) là các thông số chính được sử dụng để phân tích ứng xử của kết cấu áo đường mềm (KCAĐM). Các nghiên cứu trên thế giới cũng như ở Việt Nam chỉ ra các thông số này phụ thuộc vào nhiệt độ và tần số tác dụng tải trọng. Tuy nhiên, TCCS 38:2022/TCĐBVN vẫn đang sử dụng mô đun đàn hồi tĩnh lấy theo nhiệt độ bề mặt đường và coi hệ số Poát xông là hằng số đối với các lớp BTN và ĐGCN ở chiều sâu khác nhau trong KCAĐM. Để xét ảnh hưởng của phân bố nhiệt độ theo chiều sâu đến ứng xử của KCAĐM, bài báo này tiến hành tính toán biến dạng kéo khi uốn tại đáy lớp BTN/ĐGCN phía dưới và biến dạng thẳng đứng tại đỉnh nền đường của một số KCAĐM cho trường hợp có xét đến sự thay đổi nhiệt độ theo chiều sâu kết cấu áo đường và tốc độ dòng xe bằng phần mềm Viscoroute 2.0. Phân tích, so sánh các kết quả tính toán cho thấy mức độ ảnh hưởng của phân bố nhiệt độ trong KCAĐM và tốc độ xe chạy đến biến dạng kéo khi uốn và biến dạng thẳng đứng lớn nhất tại đỉnh nền đường là đáng kể, cần phải được xem xét khi tính toán, thiết kế
Utilidad del análisis molecular de la bilis en la estenosis biliar maligna
Authors:   , Rullán Iriarte María
Published: October 2024

La hipótesis de trabajo de la tesis se basa en que la exploración y búsqueda de nuevos biomarcadores en la bilis a través del análisis lipidómico, proteómico y secuenciación del ADN, podrían mejorar el rendimiento diagnóstico de las técnicas actuales anatomopatológicas utilizadas en los pacientes con estenosis biliares. Además de esta mejora, la identificación de los escenarios clínicos en los que utilizarlos y su evaluación económica permitirían seleccionar las técnicas diagnósticas más eficientes para mejorar el manejo de estos pacientes en la práctica clínica habitual (diagnóstico precoz, evitando la repetición de pruebas invasivas e intervenciones innecesarias, identificación de mutaciones accionables que permitan el desarrollo y utilización de tratamientos dirigidos) y así, indirectamente, contribuir a un aumento de la supervivencia de dichos pacientes.
Entropy Generation in Third-Grade Non-Newtonian Fluid Flow and Heat Transport Through Porous Medium in a Horizontal Channel under Heat Generation
Authors: Olkha Amala , Kumar Mukesh , Choudhary Rahul
Published: October 2024

In this study, entropy production in flow along with heat transport of non-Newtonian fluid via porous medium, is analyzed. For fluid flow via porous medium, a modified Darcy resistance term, is taken in the momentum equation for third-grade fluid. Temperature-dependent viscosity is considered using Vogel’s model viscosity. Using adequate transformations, the momentum and heat transport equation are reduced to non-dimensional form and solved analytically invoking homotopy analysis method on MATHEMATICA software. Effects of parameters arising in the study are depicted by graphs on velocity distribution, temperature distribution, and entropy production with Bejan number and discussed. For validity of current findings, the values of velocity and temperature are computed for particular values of the parameters and equated with previously published results, excellent agreement achieved. Furthermore, skin-friction coefficient and Nusselt number values are expressed in tabular form for various values of relevant parameters and discussed. It is noticed that slip parameters $\left( \gamma \right)$ and $\left( \beta \right)$ reduce the entropy generation number $\left( NS \right)$. Also noticed that skin friction coefficient upsurges with rising velocity slip parameter $\left( \gamma \right)$ value while, effect of temperature slip parameter $\left( \beta \right)$ is observed to lessen Nusselt number in the absolute sense.
HIGHLIGHTS

Entropy production in third grade non-Newtonian fluid flow and heat transfer in a channel via porous medium is investigated in the presence of a heat source. Slip boundary conditions are applied.
The resulting governing equations are solved analytically using the homotopy analysis method (HAM).
Maximum entropy production observed near the lower wall of channel and Bejan number attains maximum value in middle of the channel.

GRAPHICAL ABSTRACT
ECONOMIC EFFICIENCY OF APPLICATION OF OPTIMIZED MILL BED
Authors: А. S. Berg  , О. А. Nurzhanova  , О. М. Zharkevich  , А. А. Berg
Published: October 2024

This paper presents the selection of optimization parameters for the bed geometry of a long metal cutting machine (MCM), the design problem and boundary conditions were given. Five different geometries were designed for further mathematical analysis to meet the requirements of the problem. Static analysis of the mathematical model of the bed shells was performed by finite element method (FEM) using BETA CAE System tool, ABAQUS, which showed that by using stiffeners in the form of two variable pitch spirals and three hollow tubes, as well as changing the design at the connection point of the beam support to the bollards of the long bed of the metal cutting machine, the stresses that occurred in these places at an angle of 90° were reduced. The geometries were chosen in such a way that it was possible to reduce the stresses occurring at the point of cutting, to reduce the deflection, to increase the rigidity of the structure. The economic calculation aimed at determining the cost of a long metal-cutting machine tool with the proposed geometry has been carried out. The analysis of the unit cost of the product (long bed of the metal-cutting machine tool made of polymer concrete with optimized geometry) has been carried out, the calculation of the annual economic effect from the use of the proposed method of manufacturing has been carried out. Keywords: MCM, FEM, statistical analysis, product cost, economic calculation.
PROSPECTS FOR THE USE OF COMBINED METAL-CUTTING TOOLS FOR THREADING
Authors: A. Zh. Kassenov  , A. Zh. Taskarina  , A. V. Mazdubay  , K. K. Abishev  , A. D. Suleimenov
Published: October 2024

This article examines the use of combined metal-cutting tools for performing threading operations. The main purpose of the work is to analyze the effectiveness of using these tools in terms of improving accuracy, productivity and cost-effectiveness of processing. Combined tools show significant advantages over traditional methods, including reduced processing time, improved accuracy characteristics and reduced equipment maintenance costs. The design features and principles of operation of boring threaded cutters and threaded combs, as well as their impact on production processes and the quality of final products, are considered. Threading with the use of combined metal cutting tools allows you to integrate several technological operations in one cycle, which helps to increase efficiency and reduce basing errors. Experimental data confirm that the use of comb cutters contributes to a significant increase in processing accuracy and productivity, as well as reducing the time required to perform operations. Comparative analysis has shown that combined tools provide a higher quality of the thread being cut and an extended service life compared to traditional processing methods. Keywords: combined metalcutting tools, threading tools, boring threaded cutters, threaded combs, threading, productivity, processing quality.
ОЦЕНКА ЭФФЕКТИВНОСТИ ДОБАВОК МЕТАЛЛУРГИЧЕСКОГО ШЛАКА С РАЗЛИЧНЫМИ ГРАНУЛОМЕТРИЧЕСКИМИ РАЗМЕРАМИ НА ПРОЧНОСТНЫЕ ПОКАЗАТЕЛИ СТРОИТЕЛЬНЫХ ИЗДЕЛИЙ
Authors: К. М. Акишев  , Ж. Нуртай
Published: October 2024

По сведениям из открытых источников на сегодняшний день в Республике Казахстане сосредоточены отходы черной металлургии в объеме превышающем 6 млрд.т. При этом переработка отходов черной металлургии не превышает 2 %. Такой низкий процент утилизации и вторичного использования отходов черной металлургии, объясняется прежде всего, отсутствием интереса со стороны частного бизнеса и высокой стоимостью извлечения из техногенных отходов металлов и сопутствующих компонентов. Одним возможных способов утилизации отходов черной металлургии является возможность использования в качестве добавок в состав тяжелых бетонов. В представленном исследовании, в качестве добавок в состав тяжелого бетона, использовался металлургический шлак ТОО «Кастинг» различного гранулометрического состава (от 0.5÷10мм). Контрольные образцы из разработанных составов тяжелых бетонов были испытаны на прочность на сжатие. Из наиболее качественных составов бетонных смесей, были произведены опытные образцы строительных изделий различной номенклатуры, подвергнутые испытанию на сжатие. Как показывают экспериментальные данные, наиболее высокую прочность имеет состав тяжелого бетона с гранулометрическими размерами металлургического шлака проходящего через ячейку 0,5 лабораторного сита, из которого были изготовлены тротуарные плитки. При этом прочность на сжатие строительного изделия, составляла 99,69МПА. Наименьшую прочность показал тяжелый бетон с гранулометрическими размерами металлургического шлака 2,5 мм. Прочность на сжатие камня пустотелого стенового составила 1, 746МПА. При этом металлургический шлак с гранулометрическим размером от 0,63÷1,25 показал прочность на сжатие для камня пустотелого стенового не менее 10МПА. Производимые из такого состава строительные изделия могут быть использованы в местах с интенсивным движением, а также в производствах с агрессивными средами. В результате проведенных испытаний, выявлено, что гранулометрический размер, не всегда влияет на прочностные показатели строительного изделия-это прежде всего связано с процентным содержанием металлургического шлака, марки цемента, качества водно-цементного раствора. Ключевые слова: металлургический шлак, бетон, прочность, гранулометрический размер, строительное изделие.
ИЗУЧЕНИЕ КИНЕТИКИ ПРОЦЕССА ВЫЩЕЛАЧИВАНИЯ ЗОЛОТА ИЗ ХВОСТОВ ОБОГАЩЕНИЯ МАЙКАИНСКОЙ ЗОЛОТОИЗВЛЕКАТЕЛЬНОЙ ФАБРИКИ №1
Authors: Ж. Шошай  , Р. В. Сапинов  , М. А. Саденова
Published: October 2024

Во всем мире актуальны вопросы рационального использования природных ресурсов, за счет вовлечения в производственный цикл техногенных отходов. В Республике Казахстан к настоящему времени накоплено большое количество техногенных отходов, в частности в Павлодарской области имеются существенные залежи техногенных месторождений золота – хвосты обогащения золотоизвлекательных фабрик, создающих серьезную нагрузку на экологию региона. Запасы техногенного золотосодержащего сырья накопленного за годы работы концерна Казахалтын составляют порядка 25 млн. тонн, а запасы илов в хранилище Майкаинской золотоизвлекательной фабрики №1 составляют более 1 млн. тонн. Разработка таких месторождений имеет ряд преимуществ, поскольку сырье извлечено на поверхность и измельчено. Как правило, золото в хвостах содержится в виде тонких вкраплений в сульфидах, трудно поддающихся цианированию. В данной работе рассматривается кинетика процесса гидрометаллургического извлечения золота из хвостов пиритной руды АО «Майкаин Золото» с предварительным микроволновым обжигом. В результате проведенных лабораторных исследований в продуктивный раствор удалось перевести 94 % золота. Было установлено что Eкаж процесса выщелачивания Au после микроволнового (СВЧ) обжига составлило 31,3 кДж/моль, что соотвествует промежуточному режиму. Ключевые слова: хвосты, золото, гидрометаллургия, кинетика, пирит, сверхвысокочастотное излучение (СВЧ).
The Role of Geographic Information Systems (GIS) in Participatory Conservation of Heritage Areas
Authors:   School of Architecture, College of Fine Arts, University of Tehran, Iran, Salimi Hamid , Fadaei Nezhad Bahramjerdi Somayeh ,   School of Architecture, College of Fine Arts, University of Tehran, Iran, Tootoonchi Rana ,   Institute of Archaeology, Heritage Conservation and Art History, Otto- Friedrich University of Bamberg, Germany
Published: October 2024

In contemporary heritage management, participatory approaches play a crucial role in identifying and safeguarding values for a diverse range of stakeholders. This inclusive methodology involves professionals, local communities, historians, conservationists, and policymakers in conservation efforts. Successfully addressing challenges in stakeholder engagement is crucial for promoting ownership and stewardship, thereby supporting sustainable conservation efforts. Various methods such as community workshops and collaborative mapping exercises have been adopted. Geographic Information Systems (GIS) have emerged as a valuable tool in facilitating stakeholder participation. This research explores the potential of GIS in participatory heritage conservation. It aims to present principles and considerations to outline the practical application of GIS in engaging communities for heritage conservation. By bridging traditional heritage management practices with contemporary participatory methods, the research aims to enhance inclusive, informed, and sustainable conservation efforts. On this basis, qualitative methods and logical argumentation are used to analyze research content, drawing on qualitative and quantitative data from previous studies. A conceptual model is presented through a literature review, followed by an evaluation of five case studies from Iran, The USA, Finland, Egypt, and Spain that have utilized GIS in participatory planning processes. The research highlights GIS's capability to capture diverse social groups' perspectives on heritage values and priorities using participatory mapping. This integration of community insights empowers stakeholders in decision-making processes, enhancing inclusivity in heritage management and supporting community-driven initiatives for urban heritage preservation.
ASSESSMENT OF TREE BIODIVERSITY AND CARBON STOCKS IN RANGAN HIRAN SOCIAL FORESTRY AREA, GUNUNG MAS, INDONESIA
Authors: Siti Maimunah  , Avianto Yovi , Noviyanto Amir , Indra Jaya Galang , Satya Nugraha Nanda Satya , Rawana  , Samek Jay H
Published: October 2024

Rangan Hiran Village, located in the upper reaches of the Kahayan River within the Mirimanasa Subdistrict, encompasses an officially designated area of 875 hectares assigned by the state. The necessity of conserving the forest in this region arises from the significant effects of community initiatives on the Kahayan watershed. Instiper Yogyakarta, a forestry educational institution, has launched a program to educate the community about the inherent value of ecosystem services, potential alternative sources of income, and the benefits they offer. The research methodology employed utilizes the Forest Inventory and Analysis Plus (FIA+) method, which was developed by USAID LESTARI in 2018 and is overseen by Michigan State University, USA. An analysis of 10 plots with a sampling intensity of 0.221% indicates a healthy state of the current forest. The carbon stock contributed by Rangan Hiran Forest amounts to 243,998.57 tons and consists of 40 different tree species. Ecologically, the forest exhibits a Menhenick Index of 2.58, a Margalef Index of 7.11, a Shannon Index of 3.43, a Simpson Index of 0.96, and an evenness value of 0.93. These identified potentials create opportunities for collaborative efforts between Rangan Hiran and Instiper Yogyakarta, concentrating on initiatives for forest conservation and the improvement of community well-being.
Biofortification Strategies for Enhancing Nutrient Content in Staple Crops: Progress, Challenges, and Future Directions
Authors:   Department of	Botany Government First Grade College, Vijayanagara, Bengaluru -560104-India, B M Rathna Kumari
Published: October 2024

Biofortification represents a key strategy to enhance the nutritional quality of staple crops and combat micronutrient deficiencies prevalent in vulnerable populations. This review explores the advancements in biofortifying staple crops with essential nutrients, highlighting the significant progress achieved through genetic engineering, traditional breeding, and agronomic practices. Despite these advancements, several challenges persist, including limitations in genetic diversity, the impact of environmental factors, and varying levels of consumer acceptance. Addressing these issues requires a multidisciplinary approach that integrates genetic, agronomic, and socioeconomic strategies. Future research should focus on optimizing biofortification techniques, expanding successful interventions, and scaling up efforts to achieve global food security and improved nutrition outcomes.
Advances in Genomic Selection for Enhanced Crop Improvement: Bridging the Gap between Genomics and Plant Breeding
Authors:   Department of	Soil Science and Agricultural	Chemistry, Faculty of Agriculture, Annamalai	University, Annamalai Nagar, Tamil Nadu 608002,	India, Bhuvaneswari R. , Saravanan K. R. , Vennila S. ,   Department of	Genetics	and	Plant Breeding, Faculty of Agriculture, Annamalai	University, Annamalai Nagar, Tamil Nadu 608002, India.,   Department of	Genetics	and	Plant Breeding, Faculty of Agriculture, Annamalai	University, Annamalai Nagar, Tamil Nadu 608002, India., Suganthi S. ,   Department of	Genetics	and	Plant Breeding, Faculty of Agriculture, Annamalai	University, Annamalai Nagar, Tamil Nadu 608002, India.
Published: October 2024

Genomic selection (GS) has emerged as a transformative approach in plant breeding, revolutionizing the efficiency and precision of crop improvement. This comprehensive review delves into the advancements in GS and its pivotal role in bridging the gap between genomics and traditional breeding practices. GS leverages genome-wide markers to predict the breeding value of plants, thereby accelerating the selection process and reducing the time required to develop new crop varieties. The advent of next-generation sequencing (NGS) technologies has significantly reduced genotyping costs, making high-throughput genotyping more accessible and practical across a wide range of crops. This review highlights the successful implementation of GS in key staple crops such as wheat, maize, and rice, demonstrating substantial improvements in yield, stress tolerance, disease resistance, and nutritional profiles.The integration of GS into breeding programs has led to notable advancements. For instance, in wheat, GS has enabled the development of high-yielding, drought-tolerant varieties, essential for ensuring food security in the face of climate change. In maize, GS has facilitated the creation of varieties with enhanced stress tolerance and resistance to major diseases, contributing to increased productivity and sustainability. Similarly, in rice, GS has been instrumental in breeding varieties with improved nutritional quality and resilience to adverse environmental conditions, crucial for meeting the dietary needs of growing populations in vulnerable regions.
Artificial intelligence in healthcare forecasting: Enhancing market strategy with predictive analytics
Authors: Olumide Emmanuel Ibikunle  , Precious Azino Usuemerai  , Luqman Adewale Abass  , Victor Alemede  , Ejike Innocent Nwankwo  , Akachukwu Obianuju Mbata
Published: October 2024

This research examines the transformative role of artificial intelligence (AI) and predictive analytics in healthcare market forecasting, with a specific focus on their application at Eli Lilly. AI-driven insights are becoming critical tools in anticipating market trends, assessing the impact of regulatory changes, and optimizing product positioning in the competitive global healthcare landscape. By leveraging machine learning algorithms and vast datasets, AI can identify patterns and correlations that traditional forecasting methods may overlook, offering companies like Eli Lilly a more comprehensive understanding of future market dynamics. The study explores how AI enhances decision-making by predicting healthcare market trends, particularly in response to regulatory shifts such as the U.S. Inflation Reduction Act. This legislative change, aimed at reducing drug prices and increasing market access, presents significant challenges and opportunities for pharmaceutical companies. AI allows firms to model the potential outcomes of such regulatory changes and adjust their market strategies accordingly. For example, predictive analytics can forecast the pricing pressures on specific drugs, helping companies develop competitive pricing models while maintaining profitability. Moreover, the research highlights the use of AI in mitigating risks associated with market volatility. By continuously analyzing real-time data, AI can detect early signals of potential disruptions—whether from economic downturns, competitor actions, or public health crises—allowing companies to take proactive measures. Additionally, AI-driven forecasting helps identify growth opportunities in emerging healthcare markets by analyzing demographic trends, disease prevalence, and healthcare infrastructure development. In conclusion, AI and predictive analytics are revolutionizing how healthcare companies like Eli Lilly approach market forecasting and strategy development. By offering deeper insights into future market conditions, these technologies not only reduce risks but also optimize product positioning and unlock growth opportunities in the global healthcare market. This research underscores the critical importance of AI in shaping the future of healthcare market forecasting.
Keywords: Artificial Intelligence, Predictive Analytics, Market Forecasting, Regulatory Impact, Healthcare Strategy