bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern Traditionalist Prose in the Reception of The Magazine “October”
Authors: Andreeva Elena A.
Published: January 2021

Purpose. This article highlights the main trends in the analysis and evaluation of village prose by critics of the journal October, which occupies one of the leading places in the series of journalism criticism of the liberal camp. The material for the study was articles published from 1980s to the present, which also allows us to consider the analysis of modern traditionalist prose by criticizing the October in the diachronic aspect.
Results. The characteristic features of the liberal criticism are its non-ideological character, analyticity, universality and text centricity. In interpreting “village” prose, the focus of liberal critics shifts from the system of value guidelines and ideas broadcast by this group of writers to the peculiarities of its poetics and cultural context. In the 1980s the place of “village” prose in a number of works of modernity is being actively investigated. It was perceived as literature focused on a “simple” person, to his personality and his soul, focused on the moral issues of life and showing some ideals, role models in the era of the crisis of the spiritual principle in literature. Its philosophical and moral character, the ability to pose the most important issues of our time, to rethink historical events, in particular the events of collectivization, are noted and appreciated. Interest in it fades away with the beginning of the 1900s, when “village” prose begins to be associated with the era of stagnation, and the writers themselves are accused of excessive conservatism and extreme nationalism. In the 2000s, appeals to “village” prose were single and related to the development of the “new realism” trend, which reveals common ground with the artistic phenomenon that we are considering.
Conclusion. In the 1980s, the status of “village” prose is rated quite high. It is considered in a number of contemporary artistic trends, such as confession, ontology, appeal to people. Her journalism and topicality are highly appreciated. In the 1990s the situation is changing: for the criticism of the October “village” prose becomes irrelevant. This trend holds true today.
Phonetic Aspects of the Turkic-Mongolian Language Contacts
Authors: Selyutina Iraida Ya.
Published: January 2021

The purpose of the article is to identify traces of Turkic-Mongolian language contacts in the structural and taxonomic organization of consonant systems in the South Siberian Turkic languages and the Mongolian languages of Russia and the Mongolian People’s Republic. The work is based on the generalization of the results of long-term experimental phonetic studies obtained by Siberian linguists using a complex methodology that includes both linguistic methods of phonological analysis and objective methods of articulatory and acoustic phonetics.
Instrumental data indicate significant structural and typological differences in the organization of Mongolian consonant systems, determined both by the processes of historical contact with the Turkic, Tungus-Manchu, and Ugro-Samoyed languages, and by the laws of immanent development.
Khalkha-Mongolian and Kalmyk consonantism, which is based on a trichotomic opposition in articulatory tension (strong / weak / super-weak phonemes), is closer to the Tuva and Tofa languages – the South Siberian Turkic languages of the Sayan-Baikal branch of the Circum-Baikal language Union. This specificity can be considered as a result of the assimilating influence of the Mongolian ethnic groups on the previous Turkic-speaking population: by switching to the Mongolian language, the native Turks preserved their articulatory-acoustic base in it, focused on the relevance of the 3-step gradation of units according to the degree of tension.
Another niche in the typological classification is occupied by the Hori-Buryat consonant system, structured by the binary opposition of weak and super-weak consonant phonemes. The unacceptability of highly stressed settings for the articulatory base of native speakers includes the Khori-Buryat language in one cluster with the Turkic languages of the Altai-Sayan branch of the Circum-Baikal language Union (Altai, Khakass) formed on the Ugro-Samoyed substrate.
The Yakut language, which was heavily Mongolized during the ethnic fusion of the ancient Turks and Khidans, has a consonantal system with a basic orientation to the opposition on the additional vocal cords work (voiceless / voiced / sonorous), developed under the influence of active contacts with the Tungus-Manchu tribes and under the pressure of the Russian phonological system.
Instrumental data show that the Turkic-Mongolian language community is heterogeneous in its composition and structure, and the obvious material and structural-typological proximity of the consonant systems of the Altaic group languages is the result of convergence, rather than divergence from a common root.
Modal Forms with Semantics of Desire in the Altai Language
Authors: Tazranova Alena R.
Published: January 2021

In the following article, we analyze the forms of the optative in the Altai language. The modal meaning of volition in the Altai language is expressed by various means: lexical, grammatical, analytical means, and idiomatic constructions. In the article, we offer a brief overview of the means of expression of volition. The primary focus of our study is the desiderative form with =(Ы)ксА=, along with 5 synthetic forms of optative mood: =ГАй, =СА, =(А)йын, =СЫн, =БАзЫн. We show that in the modern Altai language, the finite form with =(Ы)ксА= is widely used in spoken language, with limited compatibility. The form with =(Ы)ксА= is used with the lexical-semantic group of verbs denoting physiological, psychological, or social needs of the subject, for example: јаныкса ʻto want to go homeʼ from the verb јан= ʻto go homeʼ, кӧрӱксе= ʻto want to seeʼ from the verb кӧр= ʻto look’, etc. This form denotes the subject’s strong desire to do something related to their inner feelings and emotions experienced currently and at the moment of speech, or in the past, a desire aimed towards the future which the subject is confident about. Because this form’s semantic compatibility is limited, and the modal meaning of volition expressed by this form is defined as ‘non-locutive’ modality, we believe that it should not, at this stage of the language’s development, be viewed as optative mood, but rather as a non-productive word-forming affix.
“Alphabet Scribe” in the History of Russian Literature
Authors: Kuzmina Marina D.
Published: January 2021

The article is dedicated to the study of the most significant and popular Old Russian scribe – “Alphabetical”, written in the late 16th – early 17th century according to researchers. The assumption is made that it was replenished and adjusted over several decades, quickly responding to the demands of the times and reflecting the main processes that took place in Russian literature of the 16th and especially the 17th century. The scribe reflected the central feature of this period: the interaction of the traditional and the new, with an emphasis on the new. It demonstrates such new aspects of Russian literature of the 17th century as secularization, democratization, fiction, and individualization. It is rather telling that the vast majority of sample messages are private letters written for relatives and friends. Particularly noteworthy are the samples of ‘anti-friendly’ letters, some of which are parodies of friendly letters. They make up an organic part of the 17th century parodies, namely such satirical texts as Kalyazinsky Petition, The Dowry Document, The Tale of Ersh Ershovich, The Service of the Tavern. As it is known, parodies play a crucial role in the turning periods of literary development, which was the 17th century. In this era, first of all, the most stable and therefore most recognizable genres were parodied: business (petitions, dowry, court documents, etc.) and church (hagiographies, prayers, akathists, church services, etc.) writing. Quite noteworthy is the appearance along with these parodies of the parody of the epistolary genre, indicating that it had fully developed, and occupied a proper place in the system of literature genres, and was unmistakably recognized by authors and readers. Moreover, a new, ‘secular’ version had developed and was recognized: friendly letters, which were by no means educational, unlike those popular in Ancient Russian literature of previous centuries.
Borderline lepromatous leprosy with primary clinical manifestation in a patient with a long-term dermatological history
Authors: Yanchevskaya E. Yu. , Kovtunova V. A. , Dumchenko E. V. , Duiko V. V. , Levicheva Yu. Yu.
Published: January 2021

Despite the low number, the cases of leprosy continue to be detected, more often on endemic territories. In Russian Federation one of the endemic territories is located in Astrakhan region. The long incubation period eventually leads to inability to identify the source of infection. The combination of the leprosy with other dermatoses complicates the diagnosing. The isolated and early skin manifestations of leprosy can be mistaken for the clinical features of other dermatoses. This article presents the description of a case study of border line lepromatosis leprosy in a patient with a long-term dermatological background. A 66-year-old male was followed up for 14 years under different dermatological diseases. In 2017, after a change in the nature of rashes, atypical for supervised nosological forms, and in connection with the resistance of clinical manifestations of diseases to the therapy, a clinical diagnosis of leprosy was established. To verify this diagnosis, the patient was sent to the Federal State Budgetary Institution "Research Institute for the Study of Leprosy". At admission, he complained of rashes on the skin of the face, trunk, extremities, accompanied by itching, swelling, weakness and numbness in the distal extremities. As a result of clinical, laboratory examination (bacterioscopic examination of scarification from the skin, serological examination, pathomorphological examination of skin biopsies), the diagnosis of the underlying disease was made: leprosy, borderline lepromatous form, active stage. Complications of the underlying disease: chronic specific polyneuropathy with sensitive disorders. The described clinical situation illustrates the problem of early diagnosis of leprosy due to the variety of manifestations and low alertness of clinicians.
A new species of the Rhagovelia sarawakensis species group (Hemiptera: Veliidae) from Cambodia
Authors:   Entomological Department, Natural History Museum Vienna, Burgring 7, 1010 Vienna, Austria, Zettel H. , Laciny A. ,   Entomological Department, Natural History Museum Vienna, Burgring 7, 1010 Vienna, Austria, Pangantihon C.V. ,   Biology Department, School of Science & Engineering, Ateneo de Manila University, Loyola Heights, Quezon City, 1101 Philippines
Published: January 2021

Rhagovelia freitagi Zettel, Laciny et Pangantihon, sp. n. is described and illustrated from Cambodia. The new species belongs to the Rhagovelia sarawakensis species group. A key to the species of this group that are presently known from Cambodia, Laos and Vietnam is also given.
New and little-known species of the longicorn beetles (Coleoptera: Cerambycidae) from Iran and adjacent regions
Authors:   A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninsky prospect 33, Moscow 119071 Russia, Danilevsky M.L. , Skrylnik Yu.E. ,   Laboratory of Forest Protection, G. M. Vysotsky Ukrainian Research Institute of Forestry & Forest Melioration, Pushkinska 86, Kharkov, 61024, Ukraine
Published: January 2021

Three new species are described from Iran: Cortodera kukinae Danilevsky et Skrylnik, sp. n. (Tehran province), Dorcadion (Cribridorcadion) olegpaki Danilevsky et Skrylnik, sp. n. (Tehran province), and Phytoecia (Musaria) plyushchi Danilevsky et Skrylnik, sp. n. (Gilan province). The illustrated redescription of Dorcadion (C.) cingulatum Ganglbauer, 1884 is given. New synonyms are proposed: D. cingulatum Ganglbauer, 1884 = D. ursulaheinzi Bernhauer, 2015, syn. n. Dorcadion (C.) invicinum Pic, 1902, stat. resurr. is considered as a distinct species distributed in Turkey and North Iran. The holotypes of the new species are deposited in the collection of A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia.
New records of Diptera from the Republic of Mordovia, Russia
Authors:   National Museums of Scotland, Collection Centre, 242 West Granton Rd, Edinburgh EH5 1JA, Scotland, United Kingdom, MacGowan I. , Vikhrev N.E. ,   Zoological Museum, Moscow State University, Moscow, 125009, Russia, Krivosheina M.G. ,   A.N. Severtsov Institute of Ecology and Evolution of RAS, Moscow, 119071, Russia, Ruchin A.B. ,   Joint Directorate of the Mordovia State Nature Reserve and National Park «Smolny», Republic of Mordovia, Saransk, 430005, Russia, Esin M.N. ,   Joint Directorate of the Mordovia State Nature Reserve and National Park «Smolny», Republic of Mordovia, Saransk, 430005, Russia
Published: January 2021

A list of 55 species of Diptera from families Tanypezidae (1 species), Megamerinidae (1), Acroceridae (1), Psilidae (5), Lonchaeidae (8), Strongylophthalmyiidae (1), Ephydridae (21) Scathophagidae (17 species) collected in the Republic of Mordovia is given. Of them Protearomyia withersi MacGowan, 2014 and Lonchaea baechlii MacGowan, 2016 are recorded from Russia for the first time. Five species, namely Megamerina dolium Fabricius, 1805, Lonchaea carpathica Kovalev, 1974, Ephydra scholtzi Becker, 1896, Strongylophthalmyia pictipes Frey, 1935 and Chamaepsila bicolor (Meigen, 1826), are new for Central part of European Russia. The families Acroceridae, Megamerinidae, Psilidae, Tanypezidae and Strongylophthalmyiidae as well as 53 species are recorded from the Republic of Mordovia for the first time.
Os entraves à população transgênero no acesso à saúde
Authors: De Castro Isabela Ferreira , Filho Alaôr Reis , Moreira Daniela Rezende , Salgado Patrícia de Oliveira , Cardoso Silvia Almeida
Published: January 2021

Objetivo: Compreender as barreiras enfrentadas pela população transgênero ao acessar o sistema de saúde, visto que esta questão é de grande importância em saúde coletiva e a literatura sobre o tema é escassa. Métodos: A pesquisa obteve uma amostra de oito artigos através de uma revisão de literatura, obtida na plataforma “Periódicos CAPES”, no período entre 8 a 12 de abril de 2019, através da busca dos termos Transgender People e Health Service Need and Demand. Os critérios de seleção incluíam estudos publicados em inglês que abordavam as necessidades e barreiras dos pacientes transgênero no sistema de saúde, e a avaliação metodológica foi realizada com base nos itens do Strobe, Consort e Coreq. Resultados: Os resultados foram agrupados e discutidos em categorias. As principais dificuldades encontradas foram: desrespeito ao nome social, discriminação e a falta de capacitação dos profissionais. Considerações Finais: O despreparo da equipe de saúde, em diferentes cenários, contribui na construção das barreiras enfrentadas pela população trans, sendo primordial a implementação de políticas públicas e a qualificação profissional para atender as necessidades de saúde desse grupo.
Should the Black Box Warning of Brodalumab and Apremilast Deter Prescribing in Psoriasis Patients with Depression?
Authors: Litchman DO, MS Graham H , Thibodeaux Quinn , Rivera-Oyola Ryan , Koo John , Fried Rick , Goldenberg Gary , Han George , Hsu Sylvia , Kircik Leon , Knuckles Melissa , Murina Andrea , Wu Jashin , Lebwohl Mark
Published: January 2021

Introduction: Psoriasis, an immune-mediated disease that manifests cutaneously with possible arthritic complications, affects millions of people in the United States and worldwide. Depression and suicidal ideation and behavior (SIB) are two prevalent comorbidities associated with psoriasis, due to the chronic nature of the disease, lack of a cure, as well as social stigma, all of which are detrimental to quality of life. Among the options available for management of moderate-severe psoriasis, apremilast and brodalumab represent recent additions to the therapeutic armamentarium for managing psoriasis. It has been suggested that the aforementioned drugs can lead to depression and possibly increase the risk for SIB. Furthermore, a black box warning was issued for brodalumab. This review challenges opinions that the drugs are solely responsible for exacerbating depression and SIB, when in fact it could be psoriasis itself.
Methods: An extensive search of available literature linking cytokines to suicidal behavior was performed. After filtering for relevance, 22 articles were reviewed in detail.
Results: Brodalumab and apremilast, both molecularly and clinically, do not objectively increase the risk for depression and/or suicidal ideation and behavior.
Conclusion: After careful review of the appropriate studies and relevant literature, patients with moderate-severe psoriasis, including those that experience depression resulting from their chronic condition, would likely benefit from early, rather than delayed initiation of effective medications like apremilast and brodalumab. The speed of response and high level of efficacy of brodalumab make it an ideal intervention for patients suffering depression caused by their psoriasis.
Imatinib-Induced Acquired Dermal Melanocytosis
Authors: Eversman Anna , Fatima Sakeena , Honda Kord , Beveridge Mara
Published: January 2021

Background: Imatinib, a tyrosine kinase inhibitor targeting bcr-abl, c-Kit, and PDGF receptors-alpha and beta, is commonly used to treat GI stromal tumors and hematologic malignancies. Hyperpigmentation is a known side-effect of imatinib, with intradermal hemosiderosis being the most common histologic finding.

Case Presentation: We report a rare case of concurrent hypopigmentation and hyperpigmentation secondary to dermal melanocytosis following imatinib treatment in an African American patient with acute lymphoblastic leukemia.

Conclusion: Early referral to dermatology in patients with similar findings is appropriate given the increased risk of melanoma conferred by heightened melanocyte proliferation.
What is the True Etiology of “Recurrent Shingles”?
Authors: Vangipuram Ramya , Nguyen Harrison , Tyring Stephen
Published: January 2021

Purpose:  To determine the true etiology of cases of putative recurrent shingles referred to a dermatology clinic.
Methods: A prospective cohort study of patients aged 15-87 years with reported recurrent herpes zoster was conducted. Vesicular fluid and serology for herpes simplex 1, 2, and varicella zoster virus immunoglobulins were obtained from patients presenting with vesicles. Biopsies were obtained from patients with ambiguous presentations.
Results:  44 patients (56%) had evidence of herpes simplex virus infection. 32% of patients had positive herpes simplex virus cultures or polymerase chain reaction sequencing, and 24% additional patients were diagnosed with presumptive simplex infection based on elevated antibody titers. 44% of patients had a diagnosis other than zoster or simplex. One individual had a positive viral culture for varicella zoster virus. 99% of patients who presented with suspected recurrent herpes zoster had no definitive evidence of varicella zoster virus reactivation.
Conclusions:  The most common diagnosis was herpes simplex infection. Our results suggest that true recurrent shingles in immunocompetent patients is rare.
New Cases of Syphilis and Molluscum Contagiosum in the COVID-19 Pandemic: A Sign That Social Distancing Guidelines Are Not Being Adhered to?
Authors: Heibel Haley Danielle , Dhaliwal Parneet , Cockerell Clay J.
Published: January 2021

Social distancing has played an important role in reducing the transmission of COVID-19, and, if the general public uniformly followed social distancing guidelines, we would theoretically expect no new diagnoses of sexually transmitted diseases (STDs) during this time period.  However, during the COVID-19 era, we have diagnosed multiple cases of syphilis and molluscum contagiosum histopathologically with an increased incidence in our practice from the dates of March 1 to August 28, 2020, compared with these dates in 2019.  The vast majority of these cases were not suspected by referring clinicians.  Dermatologists are experts in the recognition of the cutaneous manifestations of venereal diseases which is critical to appropriate diagnosis and management, and they should continue to provide care during this pandemic. 
Individuals who acquire STDs during this time may increase the strain on already limited health care resources by disregarding social distancing recommendations.  All medical providers must consider how we can better encourage individuals to abide by social distancing recommendations, optimize care for patients during the pandemic, and prevent the misallocation of valued health care resources.
TP53 Mutated Metastatic Basal Cell Carcinoma Responsive to Sonidegib
Authors: Wanner Brian , Cusick Austin , Kapil Jyoti , D'Addario Stephen
Published: January 2021

Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer (NMSC) with the potential of local invasion and distant metastasis. Our patient presented with an enlarging four-centimeter subcutaneous nodule over the right clavicle. An incisional biopsy demonstrated the unexpected findings of a nodular and infiltrative BCC. Definitive treatment was a radical neck dissection with adjuvant radiation therapy. Negative margins were confirmed on the excision and lymph node evaluation demonstrated no lymphatic spread. Surveillance chest computed tomography revealed new bilateral pulmonary nodules and a subsequent biopsy showed metastatic BCC. A genetic panel demonstrated TP53 mutations and no mutations in SMO. The patient was started on sonidegib and after ten months of therapy his disease was stabilized on repeat imaging. This case report demonstrates a rare presentation of a TP53 mutated, metastatic BCC responsive to sonidegib.
Efficacy and Safety of Crisaborole in Patients With Mild-to-Moderate Atopic Dermatitis With and Without Comorbid Allergic Rhinitis
Authors: Spergel Jonathan , Blaiss Michael , Lio Peter , Kessel Aharon , Takiya Liza , Werth John , O'Connell Michael , Zang Chuanbo , Cork Michael
Published: January 2021

Abstract not available.
COVID-19 Pandemic and Personal Protection Equipment (PPE): A Focus on Treatment of Essential Workers with Hand Dermatitis
Authors: Roebuck Heather
Published: January 2021

Abstract not available.
Specifically Targeting Interleukin-13 with Tralokinumab Improved Sleep in Two Phase 3, Randomized, Double-Blind, Placebo-Controlled Trials in Patients with Atopic Dermatitis
Authors: Silverberg Jonathan , Barbarot Sebastien , Gooderham Melinda , Simon Jan , Simpson Eric , Kurbasic Azra , Olsen Christina , Cork Michael
Published: January 2021

Abstract not available.
Chondroblastoma of bone: case presentation, immunohistochemistry findings and literature review
Authors: Cohn Adelina-Maria , Costache Simona , Pop Doina Mihaela
Published: January 2021

Chondroblastoma is a rare benign cartilage-producing tu­mor, with an incidence of approximatively 1% of all pri­ma­ry bone tumors. It arises mostly in the second decade of life, affecting mainly the ends of the long tubular bones. We present two cases of chondroblastoma diagnosed and trea­ted in the “Foişor” Orthopedics, Traumatology and Oes­teo­articular TB Clinical Hospital, Bucharest, Romania. The purpose of this study is to contrast two different forms of presentation of the same histologic entity: one case of a 19-year-old male patient with a chondroblastoma lo­ca­ted in the proximal humerus, and the case of a 37-year-old male patient with a chondroblastoma of the cal­ca­neus. The mor­phological fea­tures, radiologic aspects and im­mu­no­his­tochemical stu­dies have been assessed. None of the cases presented with spe­ci­fic radiologic signs for chondroblastoma, both lesions being osteolytic and well-delineated, in favor of a benign en­ti­ty. The classic mor­pho­lo­gical aspects of chondroblastoma re­pre­sen­ted by tumor cells with round poly­gonal shape and nuclei with longitudinal grooves were as­so­cia­ted with variable amounts of chondroid matrix, pe­ri­cellular calcification and few randomly distributed osteo­clast-like giant cells. The im­mu­no­his­to­chemical studies showed the osteoblastic and chon­dro­blastic phenotype of the neoplastic cells, sustained by positivity for CD56 and S100. DOG1, cytokeratin 8/18 and smooth muscle actin (SMA) were also found focally po­si­tive. All cases were treated by curettage with bone graf­ting, without recurrence in the short-term follow-up. Given the nonspecific radiologic findings and the histologic he­te­ro­ge­nei­ty, chondroblastoma is sometimes misinterpreted as a ma­lig­nant tumor, while this neoplastic lesion has a benign be­havior and benefits from conservative surgical treatment only.
Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles
Authors: Dang Shishuai , Huang Zhengwei , Huang Ying , Pan Xin , Wu Chuanbin
Published: January 2021

Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.
Purification, Characterization, Optimization and Evaluation of Bioactivity Potential of Exopolysaccharides of Curvularia Lunata
Authors: Prakash P  , Aishwarya B  , Poornimaa B  , Shaik Asma Taj  , Narendrakumar G  , Antony V Samrot  , Abirami S  , Jane Cypriyana P J
Published: January 2021

Extracellular polymeric substances are present abundantly in the surroundings which are produced by different types of microorganisms like bacteria, fungi, algae are also produced by different varieties of plant species. Exopolysaccharides (EPS) are high-molecular-weight polysaccharides secreted by microorganisms into the surrounding environment. These polysaccharides have tremendous application in pharmaceutical industries. For the past two decades, exopolysaccharides of fungus have been known to have high-value biomacromolecules. In most of the studies, sugar compositions of fungus Exopolysaccharaide and variation in molecular weight depend upon culture medium composition and different physical conditions that take place during the process of fermentation. In this current study, the selection of nutrients for the EPS production from Curvularia lunata under submerged batch-culture conditions was made using the Plackett - Burman design matrix method. Subsequently, the optimal condition was determined using Response Surface Methodology (RSM). Thus, produced EPS was characterized by GC-MS and thermogravimetric analysis. It was found to have glucose and mannitol and also showed good thermal stability. EPS was subjected to DPPH assay for analyzing antioxidant activity. Free radical scavenging activity was observed by subjecting the sample to the ABTS method and anticancer activities were tested against HeLa cells. EPS was found to be having a good antioxidant activity, Free radical scavenging activity and showed effective anticancer activity against HeLa cells.
A Comparative Study on the Carbohydrate proৎile and In-vitro Glycaemic Index of Processed Basil (Ocimum basilicum) Seeds Incorporated Idlis
Authors: Arivuchudar R  , Nazni P
Published: January 2021

The tiny black Ocimum basilicum seeds, also called as basil or sabja seeds aid to keep blood sugar levels under control by decelerating the carbohydrate conversion into glucose, a simple sugar. Raw and Steamed Ocimum basilicum seeds in the proportions of 5% (RV1, SV1), 10% (RV2, SV2), 15% (RV3, SV3) and 20% (RV4, SV4) of the black gram have been incorporated in the idli formulation. The results depicted that as the proportion of O.basilicum seeds increased the total carbohydrate and sugar values showed a decline, whereas the cellulose, hemicellulose and resistant starch values increased. At 120 minutes, the mean in vitro glycaemic index of the control idli was estimated to be 66.45 ± 0.03, while the mean estimated glycaemic index value of raw O.basilicum seed incorporated variations of idli namely RV1, RV2, RV3 and RV4 were 55.09 ± 0.02, 53.19 ± 0.02, 51.44 ± 0.01 and 48.09 ± 0.01 respectively. The mean estimated glycaemic index value of steamed O.basilicum seed incorporated variations of idli SV1 was found to be 62.72 ± 0.01, SV2 was 60.43 ± 0.01, SV3 was 58.16 ± 0.02, and SV4 was 56.63 ± 0.02 at 120 minutes. Hence it is opined that the 20% raw O.basilicum seed incorporated idli is very much low in estimated G.I values can be used in idli preparation as a means to offer a lower glycaemic index to the obese, diabetic and cardiac disorder populations.
Content Based Image Retrieval System for Lung Cancer Detection Using Neural Network and Circular Hough Transform
Authors: Rejiram R  , Kanniga E
Published: January 2021

Computer Aided Detection (CAD) systems that automatic detection and localize lung nodules in CT scans. A major problem in this system is a large number of false positives because of no provision for comparison of the predicted output. This paper recommends a new system with a  combination of CBIR and neural network to full fill the gap in the area of early detection of lung cancer. From the preprocessed CT scan image, the system identifies whether it contains nodules using Circular Hough Transform and classifies into benign or malignant nodule using Probabilistic Neural Network. Then, it searched for the most identical pictures and retrieved it from the database. From the retrieved image,  it is easy to identify the present cancer stage of the patient. Experiments have done based on both LIDC database and the locally collected database. The performance evaluation of the system is done by using both. The experimental results show that the present study easily differentiates benign and malignant nodules with an efficiency of 97 % accuracy on LIDC dataset, 95 % accuracy on Local dataset and similar images are retrieved with its present stage from the available database with a higher precision and recall rate.
Effect of Application Bundle Skin Care on Nurses’ Performance and Orthopedic Patients’ Skin Outcome: Quasi-Experimental Study
Authors: Gehan Abd Elfattah Atia Elasrag  , Nahed ELnabawy Elsabagh  , Shahenda A. Salih  , Marwa Mohamed Ahmed Ouda
Published: January 2021

Treating severe pressure ulcers may consume considerable manpower, time, and medical resources. Pressure ulcers can be avoided and effectively treated when nurses conduct proper skin assessment and care for wounds appropriately. Research hypothesis: There was positive impact of bundle skincare training on nurses' performance and orthopedic patients' skin outcome. quasi-experimental design was utilized at orthopedic units at Shebin El Koum teaching Hospital and Menofia University Hospital. Tools used for data collection were Pre-designed Questionnaire contained on nurses' characteristics, Attitude Rating Scale and Nurses' knowledge, also used Observational Checklist and BRADEN scale. The subject composed of 45 nurses and 90 orthopedic patients. Mean score of total knowledge pre-intervention was 6.83±3.1, while at the post was 9.95±2.1. Also, a mean score of total practice pre-intervention was 7.11±2.6, while at the post was 11.83±3.4, and, a mean score of total attitude pre-intervention was 5.02±2.8, while at the post was 7.82±1.9. Mean score of BRADEN scale at pre-intervention was 12.81±3.04, while at the post was 13.45±1.99. Application bundle skin care had a positive effect on nurses' knowledge, practice and attitude related skincare for orthopedic patients. So, there was an improvement at BRADEN score of patients post-application bundle skincare. Age, gender and previous hospitalization, BMI, and length had positive predictor effect on pressure sore risk. Skincare bundle for orthopedic patients is acceptable and has the potential to improve nursing care.
In silico analysis of protein-protein interfaces: Tools and approaches
Authors: Christina Nilofer  , Arumugam Mohanapriya
Published: January 2021

Two or more proteins interact in vivo to perform complex molecular functions including catalysis, regulation, assembly, immunity and inhibition through the formation of stable interfaces. This interaction is governed by several factors that are selective, sensitive and specific in nature. Several interface features has been documented since 1975. The study of these interface features of proteins and their dynamicity during interaction with different proteins help understanding the mechanisms underlying diverse molecular functions and its biological processes. Computational tools greatly assist in studying such interface features that determine the interaction between two or more proteins, and in this context, this review enumerates the different interface features reported thus far along with the tools that aid in deciphering protein features (physicochemical characteristics, binding site and interface residue prediction and hotspot residues) along with their approaches that are employed in the prediction these features. Also, the review discusses the advantages and limitations of experimental techniques and computational biological tools deployed for deciphering the protein-protein interactions. Altogether, the review will provide insights into the optimal tools and different strategies involved in protein interaction studies that would facilitate the researchers to understand the protein structural features and molecular principles of protein-protein interaction with known functions.
Relationship between class 1 dental caries and sextant involving caries among patients visiting the outpatient department of Saveetha Dental College, Chennai, India
Authors: Ankita Komal Labh  , Anjaneyulu K  , Geo Mani
Published: January 2021

Depending upon the site of the tooth, accessibility of oral hygiene products like toothbrush, tooth floss etc. different teeth have varying susceptibility to getting infected by cariogenic bacteria. Plaque accumulation, occlusal morphology, oral hygiene practices etc. play an important role in determining the susceptibility of teeth towards caries. A retrospective cross-sectional study was conducted using patient records from the Dental College, Chennai after reviewing and analysing the data of 86000 patients between June 2019 and March 2020. The variables involved were age, gender and site of carious teeth. Data were then exported to the Statistical Package for Social Sciences (SPSS) for Windows (Version 19, 2010) for further analysis. The total sample size was 19014. The sample had a gender distribution of 55.56% males and 44.44% females. Class 1 dental caries was found to be most prevalent in sextant 6 that is the lower right posterior teeth region. Least incidence of class 1 DC was noted in sextant 5, which is the lower anterior teeth. Young adults (18-35 years) had the highest incidence of class 1 dental caries (p<0.05). Among males and females, respectively, class 1 caries was most prevalent in sextant 6 (p<0.05). Within the limits of the study, it can be concluded that caries experience is highest in mandibular posteriors. There was a slight male predilection in the prevalence of class 1 dental caries. Young adults in the age group, 18-35 years, have the highest incidence of class 1 DC.
Knowledge Impact of Negative Pressure Wound Therapy on Diabetes wound
Authors: Bhuvaneswari G  , Devika S
Published: January 2021

Wound assessment is obligatory to plan and complete administration regimens and to assess care. As indicated by diabetes imperative distributed by the international diabetes federation (IDF), there were an expected 40 million people with diabetes in India in 2007 and number is anticipated to ascend to just about 70 million individuals by 2025. Negative pressure wound treatment (NPWT) is an innovation that is as of now utilized broadly in wound consideration and is advanced for use on complex injuries (open injuries) NPWT includes the utilization of an injury dressing through which a contrary weight is applied, regularly with any twisted and tissue liquid drawn away from the territory being gathered into a canister.  The present study aims to assess the knowledge impact of negative pressure wound therapy on diabetes wound among staff nurses. The one group pre and post-test design were conducted among 50 staff nurses. Purposive sampling techniques were used to select samples. A self-administered questionnaire was used to collect demographic data and knowledge on negative pressure wound therapy was assessed. The video was shown to the staff nurses after pre-test. The present study also shows that the demographic variables sex, professional qualification and wound care experience shows significant association with the post-test level of knowledge among staff nurse at p<0.0001 level and the demographic variables has shown statistically significant association with the post-test level of knowledge among staff nurse. This study concludes that video-assisted teaching program was significantly effectiveness in increasing the knowledge regarding negative pressure wound therapy.
Influence of high temperatures and solar radiation on accidents on road transport in the summer
Authors: Yakunin I. N.
Published: January 2021

Introduction. During the hot season, there is a positive relationship between the number of accidents per thousand registered vehicles and the air temperature. At the same time, an increase in the temperature and intensity of solar radiation helps to reduce the braking distance of cars. Consequently, the likely reasons for the increase in the number of accidents is a decrease in the level of driving skills. The purpose of the work is to determine the most significant causes of road accidents in the summer, the degree of their impact on accidents in conditions of high temperature and solar radiation, as well as the impact of climate installations on the increase in accidents.

Materials and methods. In order to identify the causes of the increase in accidents, an expert method was used, which consisted in a survey of 28 professional drivers with at least three years of experience. To assess the significance of factors, the reasons for the increase in accidents were ranked according to a four-point system, where the number “1” corresponded to the lowest significance, and the number “4” – the highest. It was also necessary to indicate the increase in the adverse effect as a percentage in certain conditions, compared with comfortable conditions.

Results. It is revealed that the main reasons for the increase in the number of accidents committed in the summer are: an increase in traffic speed, an increase in the frequency of maneuvering vehicles, an increase in the number of incorrect decisions and an increase in the reaction time of drivers. The direct effect of solar radiation, along with the effect of high temperatures that go beyond the comfort zone, is the cause of accidents. The use of climate systems leads to redistribution of importance among the reasons for the increase in the number of accidents – increases the number of accidents by increasing the speed and frequency of maneuvering, while reducing the rate of road accidents occurring in bad judgement and increase reaction time of drivers.

Practical importance. The research provides a basis for developing measures to reduce accidents on the road in warm weather
Development of a procedure for adapting a model of adjustable intersection
Authors: Novikov I. A. , Shevtsova A. G. , Kravchenko A. A. , Burlutskaia A. G.
Published: January 2021

Introduction. The article is devoted to the development of an algorithm for checking the assessment of the adequate operation of the transport model and the application of this algorithm in practice.The research has been carried out at a regulated intersection in Belgorod, the main parameters necessary for creating a transport model have been determined. A transport model of the investigated intersection was created, an assessment of the adequate operation of the model was made, measures were proposed to increase the capacity of the investigated section of the road network.

Methods and materials. The main attention is paid to the use of the software that allows simulating transport processes at the initial stages of activities related to the organization or reorganization of road traffic. Simulation is a fast, convenient and cost-effective way to assess the effectiveness of traffic management. The modeling process helps to select the most optimal solution for the transport infrastructure.

Results. The authors have developed the algorithm for checking the adaptation of the controlled crossing model in the Aimsun software environment, and proposed a new coordination plan for crossing. Conclusion. It is concluded that it is necessary to use the software products intended for modeling transport systems.
On Migration and Indigenous Sovereignty in a Chronically Mobile World (Guest Editors' Introduction)
Authors: Chatterjee Soma , Das Gupta Tania
Published: January 2021

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高等教育课堂教学的改进与提高
Authors: 王 宜举
Published: January 2021

教学既是高校发展的生命线，也是影响学生培养质量的决定性因素。在高等教育扩大化和规模化的今天，如何提高教师教学质量是一个值得关注的话题。因此，论文针对高等教育教学的影响要素、教学存在的典型问题进行阐述，并对如何改进和提高教学质量提出了一些建议。
《最优化方法》的教学与实践——《最优化方法及其Matlab程序设计》书评
Authors: 夏 尊铨 , 王 学永
Published: January 2021

《最优化方法》是运筹学、计算数学类专业研究生的一门基础课程。众所周知，一个优化算法能否被接受关键在于其数值效果，而优化算法的数值计算必然涉及程序设计。因此，论文对马昌凤教授编写的优化算法与程序设计方面的研究生教材《最优化方法及其Matlab程序设计》从内容、系统性及可操作性进行论述，给出该书的一些亮点与特色，同时也提出进一步提升的建议。
本科院校人物水彩画课程“线上+线下”混合式教学的重要性与必要性
Authors: 曾 茂泉
Published: January 2021

从目前本科院校人物水彩画课程教学来看，单一的线下教学模式已经难以满足教学要求。如何探索“线上+线下”混合式教学模式，对本科院校人物水彩画课程教学的推进具有重要影响。结合本科院校人物水彩画课程教学模式的应用实际，“线上+线下”混合式教学作为重要的教学方式，对本科院校人物水彩画课程教学具有重要影响，在实际应用中也取得了积极效果。因此，我们应立足本科院校人物水彩画课程教学实际，探讨“线上+线下”混合式教学的重要性及必要性。
试论高校学生思想教育中的美育
Authors: 李 海青
Published: January 2021

美育教育在整个高校阶段的教育有着非常重要的现实意义，它不仅可以培养学生的审美能力，还能提高情操修养，对其他学科的带动作用也是非常明显。论文从中国目前的美育教育的一些问题出发，分析了未来美育教育发展的一些思考。
微课优化中职烹饪专业教学的实践探索
Authors: 蒋 海燕
Published: January 2021

微课的教学通常是一个视频或者是一个主题，所以跟传统的课程教学体系的复杂设计相比，更简单更易传播也更容易被广大学习者接受。因此，微课自被开发以来，就被各个教学系统广泛应用。同时，也因为体量小，所以对内容质量提出了新要求。但就课程内容来讲，从选题到内容设计必然是经过反复打磨，才会用于教学。
主体型课堂实效性的探索
Authors: 周 会莲
Published: January 2021

提高课堂教学效率，是全面提高教学质量的基本要求，是实施素质教育的一项重要任务，也是在大力提倡素质教育的今天，一切教学措施、教学理念的落脚点和归宿。新课改下，“一切为了学生，为了每一位学生的发展”是新课程的教学理念。因此，新课程下的语文教学，既要师生互动起来，又要提高语文教学的实效性，这是值得让每一位教师认真去研究、探讨的问题。
1+X证书制度下高职商务英语应用型创新人才培养模式研究
Authors: 熊 洁
Published: January 2021

“1+X”证书制度的创建能有效推动中国职业教育制度的深化改革，培养更多综合性职业教育人才，改善在传统人才培养中存在的问题。论文主要分析了在高职商务人才培养与“1+X”证书制度之间的重要关系以及当前应用型人才培养现存问题，结合“1+X”证书制度要求研究了人才培养有效措施。
Recálculo de las tendencias de mortalidad por accidentes, suicidios y homicidios en Argentina, 1997-2018
Authors: Santoro Adrián
Published: January 2021

Objetivo. Este estudio se propuso describir el impacto del registro deficiente de la causa de muerte en las tendencias de mortalidad por suicidios y homicidios mediante la imputación de información faltante.

Métodos. Estudio observacional y descriptivo de la tendencia temporal de la mortalidad por causas externas registradas en Argentina en el período 1997-2018. Para la imputación de la intencionalidad, se ajustaron modelos logísticos a partir de variables predictoras provenientes del Informe Estadístico de Defunción. Se utilizaron estadísticas vitales y proyecciones de población como fuentes secundarias.

Resultados. Medida con los datos originales, la mortalidad por causas externas descendió en homicidios y accidentes. Dichos descensos se hicieron más marcados con la información corregida, ya que la imputación impactó con mayor fuerza al principio del período. La mortalidad por suicidios registró un aumento de 8,0%, que luego de la corrección ascendió a 12,9%.

Conclusiones. La corrección no modifica de manera sustantiva la tendencia de la mortalidad por causas externas, aunque tiene mayor impacto en la mortalidad por homicidios y suicidios, elevándola.
We Thought We Knew What Summer Was
Authors: Ballard Susan , Brasier Hannah , Buck Sholto , Carlin David , Langley Sophie , Lobb Joshua , Magner Brigid , McKinnon Catherine , Michael Rose , Murray Peta , Rendle-Short Francesca , Strahan Lucinda , Taylor Stayci
Published: January 2021

Overwhelming catastrophic events have become part of the ‘new normal’ of climate change. This essayistic, collaborative lived experience report by a group of writers, each of whom lived through Australia’s 2019—2020 Black Summer of catastrophic bushfires, demonstrates how the effects of shared but different proximate relations can produce an affective, care-ful account of the lived experience of climate change. Our project asks: how might a practical entanglement with others allow for a meaningful response to climate change? How might collaboration allow for a mode that places care at the centre of writing practice?
A COMPARATIVE EXPLORATION ON DIFFERENT NUMERICAL METHODS FOR SOLVING ORDINARY DIFFERENTIAL EQUATIONS
Authors: Asif Arefin Mohammad
Published: January 2021

In this paper, the initial value problem of Ordinary Differential Equations has been solved by using different Numerical Methods namely Euler’s method, Modified Euler method, and Runge-Kutta method. Here all of the three proposed methods have to be analyzed to determine the accuracy level of each method. By using MATLAB Programming language first we find out the approximate numerical solution of some ordinary differential equations and then to determine the accuracy level of the proposed methods we compare all these solutions with the exact solution. It is observed that numerical solutions are in good agreement with the exact solutions and numerical solutions become more accurate when taken step sizes are very much small. Lastly, the error of each proposed method is determined and represents them graphically which reveals the superiority among all the three methods. We fund that, among the proposed methods Runge-Kutta 4th order method gives the accurate result and minimum amount of error.
SEISMIC RETROFITTING OF REINFORCED CONCRETE SHEAR WALL USING CARBON FIBER REINFORCED POLYMERS (CFRP)
Authors: Khan Shahzad
Published: January 2021

In this paper, the experimental results of a partially retrofitted non-compliant with code concrete shear wall using uni-directional carbon fibre reinforced polymer (CFRP) are introduced. The common deficiencies in the wall were insufficient reinforcement, un-confinement at boundary zone, the lake of in-plane stiffness, and ductility. The adopted retrofitting technique consists of the CFRP strips bonded to both wall face with mesh anchors installed in the wall panel and foundation to avoid debonding. The wall was tested before and after retrofitting under a constant axial load, and the displacement control lateral cyclic load was applied to the head beam level. The retrofitted wall showed satisfactory results in terms of drift and shear strength. The test results include the failure pattern, load-displacement behaviours, and deflected shape.