Quantitative Analysis of Calcium Oxide in the In Vivo Human Organs
Authors: Tanioka Hisaya , Tanioka Sayaka , Kaga Kimitaka 
Published: June 2021

Back Ground and Purpose

When Ca2+ reacts with O2−, CaO is synthesized. If we can detect in vivo CaO in the human body, we will be able to investigate one of the pathogenesis of calcium metabolism. CT values can be assigned to the objects. The objects are assigned to different optical properties along with X‐ray CT values. Volume rendering 3D images are generated from discrete samples of the volume data obtained by X‐ray CT. To make volume rendering 3D images of a specific object are created from its optimal thresholding, opacity, and brightness. When exposed to water, CaO converts to Ca(OH)□. Volume rendering technique is carried out on the CaO to Ca(OH)□ transformation and quantitative the amount of CaO/Ca(OH)□ under the defined threshold with 100% opacity, 100% brightness, and black and red color assignment. This simplified volume rendering algorithm has found ubiquitous applications in materials science and biology of CaO. We will present a clinical usage of several common diseases.

Materials and Methods

Two clinical body CT data of osteoporosis (one was medically treated, the other was non‐treated), COPD, arteriosclerosis and back pain were used. We used the thresholding trapezoid curved algorithm which was combined with the segmentation methodology. After transferring the image data to the CT workstation, the 3D CaO image based on interactive direct volume rendering was made.

Results

The case 1 was suffered from COPD (emphysematous type), arteriosclerosis, medically treated osteoporosis, and back pain. The 3D CaO image represented that the red lesions were seen in the ribs, the bilateral pleura or/and peripheral lung fields, the bilateral erector spinae muscle, the bilateral pedicle, the right crus, and the descending aorta posterior wall. But, there was no red lesion in the thoracic vertebra. In case 2 of postmenopausal untreated osteoporosis without any disease, there were red lesions at the cortex and the fracture lesion of the vertebra and the rib cortex. Others organs showed no CaO deposited lesions.

Conclusion

This simplified technique is adapted for only in vivo CaO detection in the human body, and will attribute an in vivo calcium function and metabolism in the human organs. This is because CaO was the highest CT value in the human body. In COPD, CaO activated at the peripheral lung fields. The arteriosclerotic wall deposited CaO. In the untreated postmenopausal osteoporosis, CaO activated at the cortex and the vertebral fracture. But, the treated case did not show CaO deposited at the cortex. These CaO accumulated regions will indicate that it is considered that a chemical reaction between Ca2+ and O2− or/and O− occurred. These images will implicate CaO metabolisms in the human organs. These facts show that CaO is an important role for several diseases. We think that this simplified technique of 3D CaO imaging makes a new step of etiological researches.

The 3D reconstructed anatomical fusion image in Case 1. The red lesions are seen at the ribs, the bilateral pleura or/and peripheral lung fields, the bilateral erector spinae muscle, the bilateral pedicle, the right crus, and the descending aorta posterior wall. .

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The 3D reconstructed anatomical fusion image in Case 1. The red lesions are seen at the ribs, the bilateral pleura or/and peripheral lung fields, the bilateral erector spinae muscle, the bilateral pedicle, the right crus, and the descending aorta posterior wall. .

Case 2: The untreated postmenopausal osteoporosis. CaO activates at the cortex and the vertebral fracture.

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Case 2: The untreated postmenopausal osteoporosis. CaO activates at the cortex and the vertebral fracture.

This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.