bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Authors: Mackowiak Claire , Marchiol Tiffany , Paljetak Hana Cipcic , Fauconnier Louis , Palomo Jennifer , Secher Thomas , Panek Corinne , Sedda Delphine , Savigny Florence , Erard Francois , Bragonzi Alessandra , Huaux Francois , Stoeger Tobias , Schiller Herbert B , Sirard Jean-Claude , Le Bert Marc , Couillin Isabelle , Quesniaux Valerie F J , Togbe Dieudonnée , Ryffel Bernhard
Published: May 2021

Cystic fibrosis is associated with chronic Pseudomonas aeruginosa colonization and inflammation. The role of MyD88, the shared adapter protein of the proinflammatory TLR and IL-1R families, in chronic P. aeruginosa biofilm lung infection is unknown. We report that chronic lung infection with the clinical P. aeruginosa RP73 strain is associated with uncontrolled lung infection in complete MyD88-deficient mice with epithelial damage, inflammation, and rapid death. Then, we investigated whether alveolar or myeloid cells contribute to heightened sensitivity to infection. Using cell-specific, MyD88-deficient mice, we uncover that the MyD88 pathway in myeloid or alveolar epithelial cells is dispensable, suggesting that other cell types may control the high sensitivity of MyD88-deficient mice. By contrast, IL-1R1–deficient mice control chronic P. aeruginosa RP73 infection and IL-1β Ab blockade did not reduce host resistance. Therefore, the IL-1R1/MyD88 pathway is not involved, but other IL-1R or TLR family members need to be investigated. Our data strongly suggest that IL-1 targeted neutralizing therapies used to treat inflammatory diseases in patients unlikely reduce host resistance to chronic P. aeruginosa infection.
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation
Authors: Wang Wenwen , Qin Ying , Song Hui , Wang Lijuan , Jia Mutian , Zhao Chunyuan , Gong Mouchun , Zhao Wei
Published: May 2021

NOD-, LRR-, and pyrin domain–containing protein 3 (NLRP3) inflammasome has been implicated in a variety of inflammatory disorders, and its activation should be tightly controlled to avoid detrimental effects. NLRP3 protein expression is considered as the rate-limiting step for NLRP3 inflammasome activation. In this study, we show that galectin-9 (encoded by lgals9) attenuated NLRP3 inflammasome activation by promoting the protein degradation of NLRP3 in primary peritoneal macrophages of C57BL/6J mice. Lgals9 deficiency enhances NLRP3 inflammasome activation and promotes NLRP3-dependent inflammation in C57BL/6J mice in vivo. Mechanistically, galectin-9 interacts with NLRP3, promotes the formation of NLRP3/p62 (an autophagic cargo receptor, also known as SQSTM1) complex, and thus facilitates p62-dependent autophagic degradation of NLRP3 in primary peritoneal macrophages of C57BL/6J mice and HEK293T cells. Therefore, we identify galectin-9 as an “eat-me” signal for selective autophagy of NLRP3 and uncover the potential roles of galectins in controlling host protein degradation. Furthermore, our work suggests galectin-9 as a priming therapeutic target for the diseases caused by improper NLRP3 inflammasome activation.
Reforming Policing Institutions: A Closer Look at EndSARS and BLM
Authors: Prinvil Christina
Published: May 2021

Policing creates a form of power that can oppress and victimize vulnerable communities, with no real consequence for abuses of that power. Both the EndSARS and BLM movements bring attention to this lack of accountability and call for reform within policing institutions. To move toward sustainable and effective change, these governments must reform their criminal justice systems to create a more equal structure of power between policing institutions and the people.
Questions & Answers:
The Migrant Protection Protocols and Immigration Courts in the United States
Authors: Rachko Thomas
Published: May 2021

In January 2019, the Trump Administration’s Department of Homeland Security (DHS) implemented the Migrant Protection Protocols (MPP), colloquially known as the “Remain in Mexico” program. The MPP is a United States government immigration policy that requires that asylum seekers be returned to Mexico to wait as their claims pend in United States immigration court proceedings. Supporters of the program argued that the policy was a step to strengthen border security and prevent human smuggling and trafficking. However, journalists, human rights organizations, and academics exposed how the policy manufactured a humanitarian crisis and stranded over 70,000 asylum seekers in dangerous Mexican border cities. This article examines the impacts of the MPP on the United States asylum and immigration court system. It explores the implementation of and Trump administration justification for the MPP, analyzes government data and evaluation of the policy, reviews investigative documentation from public reporting by media and nonprofit organizations, and sets forth recommendations for Congress and the Biden Administration to begin to reverse and repair the harms imposed on asylum seekers. Over two years later, the MPP policy is known as one of the Trump Administration’s most damaging anti-asylum policies putting asylum seekers in harm’s way.
Tabella illustrata di determinazione per le specie del genere Pterostichus note in Italia (Coleoptera, Carabidae, Pterostichinae)
Authors: Allegro Gianni
Published: May 2021

Viene presentata una chiave dicotomica per l’identificazione delle specie di Pterostichus (Coleoptera, Carabidae) note per il territorio italiano. Viene inoltre illustrato l’habitus di 56 specie.
Scedosporium species and Lomentospora prolificans in Italian cystic fibrosis patients: prevalence and distribution in seven centers using a selective medium
Authors: Cariani Lisa , Biffi Arianna , Guarneri Davide , Teri Antonio , Girelli Daniela , Vignati Chiara , Morelli Patrizia , Campana Silvia , Dolce Daniela , Iula Vita Dora , Catania Maria Rosaria , Cirilli Natalia , Rapagnani Sara , Rossitto Martina , Fiscarelli Ersilia Vita
Published: May 2021

Background and aims. Scedosporium species and Lomentospora prolificans are the filamentous fungi isolated more frequently from the cystic fibrosis (CF) lower airways, after Aspergillus fumigatus. Previous studies showed that, in CF patients, Scedosporium species and Lomentospora prolificans are responsible for airways colonization/ infection, enhancing pulmonary deterioration, and for severe invasive infections in CF patients undergoing lung transplantation. Aims of our project were to evaluate the prevalence of Scedosporium and Lomentospora species in Italian patients with CF, and to evaluate the interest of the Scedosporium-selective colture medium SceSel compared to routinely used agar-based culture media, in order to improve laboratory diagnostic performances.Materials and methods. A total of 1977 sputum samples from 1154 CF patients were collected and processed according to CF Italian recommendations in the year 2017 (January 1st to December 31st). The SceSel agar was used in addition to the routine culture procedures to burst growth and isolation of Scedosporium/ Lomentospora species. The fungal isolates were identified by classical mycological methods and polymerase chain reaction-based DNA sequencing of ITS1 and ITS4 regions. Susceptibility of the isolates to antifungal drugs was investigated by E-test method. Results. Among the 1154 enrolled patients, 62 (5.3%) were positive for Scedosporium/Lomentospora species (median age: 27y; range 8-64y; 33 male). Out of 1977 samples, 93 were positive for Scedosporium/Lomentospora species, and 13 (13.9%) were recovered only on SceSel agar. According to molecular analyses, isolation rates of each species were: S. apiospermum 53.1%, S. boydii 37.5%, L. prolificans 6.3% and S. aurantiacum 3.1%. Amphotericin B minimum inhibitory concentration (MIC) values were above or equal to 2 mg/L in all strains. Voriconazole MIC values were below or equal to 0.38 mg/L in almost all strains, proving this drug to be the most effective antimycotic for members of Scedosporium species. Otherwise, Lomentospora prolificans showed to be resistant to all considered antifungal drugs, only Voriconazole seems to be active on some Lomentospora prolificans isolates. Conclusions. Our results suggest that SceSel agar should be used in combination with routine media as standard microbiological protocol and procedures are not always adequate to isolate Scedosporium and Lomentospora species in CF respiratory samples. Molecular identification and susceptibility tests are needed, especially for strains isolated from critical patients and those considered for transplantation, as they might develop invasive scedosporiosis.
Metastatic malignant peripheral nerve sheath tumor. A diagnostic surprise
Authors: Bai Muniza , Govindaraj Vishnukanth , Chauhan Abhishek Singh , Srinivas Bheemanati Hanuman , Sree Rekha Jinkala , Narenchandra Vijayarangam
Published: May 2021

Malignant peripheral nerve sheath tumours (MPNSTs) are rare soft tissue tumors that arise from pre-existing plexiform neurofibromas or within a normal peripheral nerve. They are aggressive tumors with high rates of recurrence and distant metastases, the most common sites of metastasis being the lung followed by bone.A 46 year old gentleman presented with breathlessness and chest pain three years after post amputation of left thumb for an ulcerative growth. CECT thorax showed a left upper lobe mass with pleural and pericardial effusion. Within a month of presentation he worsened and succumbed to the disease. Antemortem biopsy of the left hand ulcerative growth showed features suggestive of malignant peripheral nerve sheath tumour- epithelioid variant and post mortem liver and lung biopsy showed metastasis of MPNST. The diagnosis was a malignant peripheral nerve sheath tumor with lung, liver and cardiac metastasis. This case report aims to highlight the importance of upfront aggressive multimodality local therapy for achieving local disease control in patients presenting with localised MPNST and regular follow up for early detection of relapse and metastasis.
Transanal irrigation (TAI) in the paediatric population: Literature review and consensus of an Italian multicentre working group
Authors: Caponcelli Enrica , Meroni Milena , Brisighelli Giulia , Rendeli Claudia , Ausili Emanuele , Gamba Piergiorgio , Marte Antonio , Iacobelli Barbara Daniela , Lombardi Laura , Leva Ernesto , Midrio Paola
Published: May 2021

Constipation and fecal incontinence in pediatric patients are conditions due to either functional or organic bowel dysfunction and may represent a challenging situation both for parents, pediatricians, and pediatric surgeons. Different treatments have been proposed throughout the past decades with partial and alternant results and, among all proposed techniques, in the adult population the Transanal Irrigation (TAI) has become popular. However, little is known about its efficacy in children. Therefore, a group of Italian pediatric surgeons from different centers, all experts in bowel management, performed a literature review and discussed the best-practice for the use of TAI in the pediatric population. This article suggests some tips, such as the careful patients’ selection, a structured training with expert in pediatric colorectal diseases, and a continuous follow-up, that are considered crucial for the full success of treatment.
The political vow of Jephthah in Judges 11:30-31
Authors: Tore Makmur , Ndolu Nelci N.
Published: May 2021

This study responds to Jephthah’s ambiguous vow that led to a heart-wrenching and outrageous tragedy. There are conflicting ideologies held by Jephthah and the Deutronomist tradition in laying the biblical theology foundations. The church is challenged to be vigilant in vowing. To achieve this goal, the text of Judges 11:30–31 is explored by using an ideological critique approach. The focus of this study is to underline the concept of Jephthah’s ideology of victory on the fighting against the enemy of Israel as a political way to prove one’s identity and get out of social discrimination at the expense of everything including his own family. Jephthah’s act was not aligned with what the Deuteronomists promoted. Attempts to incorporate any sacrificial foreign cult (including anyone) resulted in deep scars on the faith history of the Israelites. In addition, it shows that Jephthah’s leadership, which is contrary to God’s ideals, is unable to maintain its existence in international relations when it is able to maintain its religious exclusivity. This study contributes to the interpretation of biblical texts by exposing the ideological aspects of the reader to take the right stance to be aware of the tendency to cause gender violence with a vow.Intradisciplinary and/or interdisciplinary implications: This is a multidisciplinary study because it integrates biblical hermeneutics with the context of the political constellation of Christian leaders. Apart from that, it serves as a reference for reflection and dialogue that corrects, criticises or legitimises the situation in the context of ideology, history, poverty, social conflicts, political problems and gender justice for readers.
Evaluation of nutritional status of regular hemodialysis elderly patients using modified subjective global assessment score
Authors: Mahmoud Amira A. , Afifi Samir M. , Shalaby Sally M. , Al-Barshomy Said M.
Published: May 2021

Background

Malnutrition, an important problem in geriatric medicine, is becoming more recognized in hemodialysis patients, as a factor that can even worsen the prognosis and the quality of life of these patients. It is imperative for the nephrology community to recognize this syndrome of malnutrition and work to manage it. Malnutrition can be detected commonly in all age groups of dialysis patients, and it represents a sensitive marker for morbidity and mortality better than chronological age. It could also act as a major cofactor for depression and cognitive impairment development in dialysis patients. We aimed to assess the nutritive status of the elderly patients with end-stage renal disease (ESRD) undergoing hemodialysis using modified subjective global assessment score (M-SGAS) and to correlate between it and different biochemical parameters.

Patients and methods

A total of 100 ESRD elderly patients on regular hemodialysis were included. All patients were subjected to the following: history taking, including weight change, dietary intake, gastrointestinal symptoms, and functional capacity (nutritionally related functional impairments, comorbidity); physical examination, including decreased fat stores or loss of subcutaneous fat (eyes, triceps, biceps, and chest), signs of muscle wasting (temple, clavicle, ribs, knee, interosseous, quadriceps, and scapula), mid-upper arm and calf circumference, and BMI; malnutrition score (sum of all number) using SGAS; and laboratory investigations, including complete blood count, serum creatinine, blood urea, C-reactive protein, serum albumin, parathyroid hormone, serum calcium, serum phosphorus. urea reduction ratio, and KT/V.

Results

There was a decrease in anthropometric measures in both males and females, indicating that both sexes are prone to malnutrition to the same degree. On comparing between male and female patients with respect to total M-SGAS, they lie in the moderate degree of total M-SGAS, with no significant difference between males and females. There was a statistically significant negative correlation between M-SGAS and triceps skin fold, mid-arm muscle circumference, and mid-arm circumference, and also there was a statistically significant negative correlation between duration of dialysis and mid-arm circumference.

Conclusion

The M-SGAS can be used as reliable, rapid, and precise method for nutritional assessment in elderly patients with ESRD on regular hemodialysis. There is a high prevalence of malnutrition among all age groups, even those younger than 40 years old. Malnutrition is associated with female sex, hypoalbuminemia, increased inflammatory markers such as elevated C-reactive protein and elevated total leukocytic count, and in those with low hemoglobin level. Malnutrition also is more detected in patients with hyperparathyroidism.
Clinical-Radiological Prognostic Factors in Patients with Brain metastasis-A Retrospective Study from a Tertiary Care Centre in Easten India
Authors: Singh Rashmi , Kumar Anup , Munda Praveer KS , Tudu Rajanigandha , Raina Payal
Published: May 2021

Background:

Brain metastasis (BM) is the most common (MC) intracranial tumor in adults. The outcome depends upon prognostic factors (PF) and optimal use of multimodality treatment.

Objectives:

We aimed to know clinicoradiological PF and their correlation in BM patients.

Materials and Methods:

Retrospectively, 19 BM patients treated with radiotherapy (RT) for the same between January 2018 and December 2019 were selected. Details of age, sex, Karnofsky performance status (KPS), recursive partitioning analysis (RPA), primary diagnosis, histopathology report, imaging details for BM-number, size and location, extracranial metastasis (EM), and primary tumor control (PTC) status were collected from the physical records. Descriptive statistics for the categorical variables and Bi-variate Spearman correlation were used to analyze the correlation between BM size, number, type of primary (TOP) with RPA, KPS, age, gender, PTC, and EM individually using the SPSS software version 20.

Results:

84.2% of patients were <65 years age and 57.8% were males. Lung cancer was the MC primary (73.7%). The PF in majority were KPS <70 (52.6%), RPA III (52.63%), multiple BM lesions (73.7%), uncontrolled primary (78.9%), and BM size >1.5 cm (84.2%). EM was observed in 31.6% patients. 94.73% and 68.4% of patients received whole-brain RT and systemic treatment, respectively. The maximum duration of FU was 12 months and 78.9% of patients were lost to FU post-RT. Significant correlation was observed between BM size and RPA class, KPS (R = 0.456; P = 0.049), and TOP correlated with gender (P = 0.028) and PTC (P = 0.000). However, no significant correlation between the age, RT dose, EM, number of lesions and RPA, PS (P = 0.339).

Conclusions:

The presence of multiple poor PF in majority of our patients and their poor follow-up indicate inertness toward health issues. Furthermore, larger BM lesions correlated with higher RPA suggesting poor outcome, so treatment modality to be judicially selected. The positive correlation between gender, PTC and primary cancer, and their prognostic role in BM should be validated in the larger studies.
The Prognosis and the Role of Adjuvant Chemotherapy for Node-Positive Bladder Cancer Treated with Neoadjuvant Chemotherapy Followed by Surgery
Authors: Jeong Hyehyun , Park Kye Jin , Lee Yongjune , Kim Hyung-Don , Kim Jwa Hoon , Yoon Shinkyo , Hong Bumsik , Lee Jae Lyun
Published: May 2021

Purpose This study aims to evaluate the prognosis of pathologically node-positive bladder cancer after neoadjuvant chemotherapy, the role of adjuvant chemotherapy in these patients, and the value of preoperative clinical evaluation for lymph node metastases.Materials and Methods Patients who received neoadjuvant chemotherapy followed by partial/radical cystectomy and had pathologically confirmed lymph node metastases between January 2007 and December 2019 were identified and analyzed.Results A total of 53 patients were included in the study. The median age was 61 years (range, 34 to 81 years) with males comprising 86.8%. Among the 52 patients with post-neoadjuvant/pre-operative computed tomography results, only 33 patients (63.5%) were considered positive for lymph node metastasis. Sixteen patients (30.2%) received adjuvant chemotherapy (AC group), and 37 patients did not (no AC group). With the median follow-up duration of 67.7 months, the median recurrence-free survival (RFS) and the median overall survival (OS) was 8.5 months and 16.2 months, respectively. The 2-year RFS and OS rates were 23.3% and 34.6%, respectively. RFS and OS did not differ between the AC group and no AC group (median RFS, 8.8 months vs. 6.8 months, p=0.772; median OS, 16.1 months vs. 16.3 months, p=0.479). Thirty-eight patients (71.7%) experienced recurrence. Distant metastases were the dominant pattern of failure in both the AC group (91.7%) and no AC group (76.9%).Conclusion Patients with lymph node-positive disease after neoadjuvant chemotherapy followed by surgery showed high recurrence rates with limited survival outcomes. Little benefit was observed with the addition of adjuvant chemotherapy.
Megabeds in Istrian Flysch as markers of synsedimentary tectonics within the Dinaric foredeep (Croatia)
Authors: Petrinjak Krešimir ,   Croatian Geological Survey, Zagreb, Croatia, Budić Marko , Bergant Stanislav , Korbar Tvrtko ,   Croatian Geological Survey, Zagreb, Croatia,   Croatian Geological Survey, Zagreb, Croatia,   Croatian Geological Survey, Zagreb, Croatia
Published: May 2021

Istrian Flysch was deposited during the Eocene in the Dinaric foredeep and is composed of hemipelagic marls and various gravity flow deposits. The latter are predominantly 5-40 cm thick turbidites, developed mostly as laminated and cross-rippled sandstone beds (Tb-e, Tc-e and Td-e Bouma sequences). In addition to the turbidites, there are deposits characterized by a significant thickness, occasionally more than 10 m, described as complex (bipartite) megabeds. The megabeds are composed of debrites in the lower part (Division I), and high-density turbidites in the upper part (Division II). The distinct clast composition of each megabed indicates that the lithoclasts were derived from tectonically active slopes and fault scarps along which collapses of the different parts of the Cretaceous to Palaeogene neritic carbonate succession, that underlie the Flysch, occurred. The Division II deposits are well cemented, normally graded calcirudite/calcarenites composed mostly of orthophragminids, nummulitids, and red algae, originating from outer ramp environments. Redeposited marl, observed in the matrix of the debrites and as intraclasts in some megabeds, implies that the collapses along the synsedimentary fault scarps and steep slopes also occurred within the foredeep itself, during the rapid tectono-sedimentary evolution of the Dinaric foreland basin.
On James Hyde’s example of non-orderable subgroup of $\mathrm{Homeo}(D,\partial D)$
Authors: Triestino Michele
Published: May 2021

In Ann. Math. 190 (2019), 657–661, James Hyde presented the first example of non-left-orderable, finitely generated subgroup of

\mathrm{Homeo}(D,\partial D)

, the group of homeomorphisms of the disk fixing the boundary. This implies that the group

\mathrm{Homeo}(D,\partial D)

itself is not left-orderable. We revisit the construction, and present a slightly different proof of purely dynamical flavor, avoiding direct references to properties of left-orders. Our approach allows to solve the analogue problem for actions on the circle.
Is “New Culture” a Proper Translation of Xin wenhua?
Authors: Ciaudo Joseph
Published: May 2021

For several decades, we have been witnessing a profound renewal in our understanding of the “New Culture Movement”. However, the aptness of “new culture” as a proper translation for xin wenhua 新文化 has almost never been discussed. The present paper argues that uniformly translating xin as “new” and wenhua as “culture” tends to blur the picture instead of making it clearer, for by so doing one unconsciously endorses the narrative of radical Chinese intellectuals while silencing other voices. Furthermore, the article puts forward the idea that terms such as wenhua 文化 encompassed a “multiplicity of potential readings” that have much to do with the transformation of Chinese language at the beginning of the 20th century, and with the emergence of a new conceptual repertoire. In their attempts to appropriate xin wenhua and turn it into a seemingly coherent movement with an agenda, Chinese intellectuals were fighting a war over the topic of “civilization/culture”, but also, and perhaps primarily education. Yet, by employing the term “culture” in academic writing today, we tend to produce a historical dissonance for their use of this term is not our own: we thus fall into the trap of semantic transparency, and forget that the concept of “culture” has a problematic history in both China and the West. By questioning the use of wenhua with regard to the May Fourth Movement, I provide evidence that the accepted translation of culture can be problematic if one does not clearly spell out the meaning located behind it, as the Chinese wenhua often did not mean “Chinese culture” in our modern, all too modern, anthropological sense.
Japanese Reinterpretations of Confucianism
Authors: Ogrizek Marko
Published: May 2021

This article aims to introduce the study of Itō Jinsai from the point of view of the value of his Confucian interpretations within the context of the project of Confucian ethics—in other words, trying to ascertain in what ways Jinsai’s project can help facilitate the study of Confucian ethics beyond the realm of intellectual history in the global context of the 21st century. It is imperative to allow Jinsai’s notions, as much as possible, to speak for themselves; but it is also of great importance to first place Jinsai within his own time and inside the intellectual space in which he formulated his ideas. A number of scholarly sources will be considered, with the intention of illuminating Jinsai’s work from a few different angles.
The influence of nitrogen supplementation on lipase production by Aspergillus niger using palm oil mill effluent
Authors: Oshoma C.E. , Kolawole E.D. , Ikenebomeh M.J.
Published: May 2021

No Abstract.
Adsorption of methylene blue on corncob charcoal: Thermodynamic studies
Authors: Fodeke A.A. , Ayejuyone O.J.
Published: May 2021

To obtain the thermodynamic properties of adsorption of methylene blue (MB) on corncob carbonaceous adsorbents - untreated (UCC) and acid treated (TCC) - their equilibrium adsorption was determined between 10 o– 40o C at different pH conditions. The adsorption isotherms were fitted to Freundlich, Langmuir and Temkin isotherm models. The point of zero charge of each of the adsorbents was also determined. The point of zero charge was 10.58 ±0.09 for TCC, and 7.55 ± 0.10 for UCC. Only Freundlich model could account for the observed thermodynamic properties of MB adsorption by the adsorbents, though Temkin and Langmuir models have higher correlation coefficients. MB adsorption by TCC was an entropically driven process which depends on pH;ΔSo at pH 10.5 < ΔSo at pH 8.0 <ΔSo at pH 12.0. The ΔHo of the endothermic process at pH 12 is > ΔHo at pH 8 > ΔHo at pH 10.5. The results suggest that MB adsorption by the adsorbents occur by physisorption and is optimum when the pH is around the point of zero charge. It is important to ensure that in addition to fitting and equilibrium adsoption data by an isotherm model, the fit of the relevant equilibrium parameter should also be good and give thermodynamic quantities that could satisfactorily account for the observed adsorption properties of the system.  Deciding the suitability of an isotherm model for fitting adsorption equilibrium experiment based on compared error function of the fitted curves or lines through single temperature isotherm could lead to erroneous conclusion.

Keywords: adsorption, adsorbent; methylene blue; enthalpy; entropy; Freundlich
Synthesis, characterization and antibacterial activity of mixed ligand complexes of Nicotinamide and 2,2′-Bipyridine
Authors: Akinyele O.F. , Fakola E.G. , George R.C. , Durosinmi L.M.
Published: May 2021

No Abstract.
Assessment of Water Pollution Indices of Two Anthropogenic Impacted Rivers in Southern Nigeria
Authors: Edoreh J.A , Izegaegbe J.I , Osimen E.C , Inegbenosun C.U , Ojagefu H.A , Weyinmi E
Published: May 2021

Freshwater ecosystems afford essential needs and services to humans and have not been spared the effects of anthropogenic pressures exacerbated by increasing urbanization and industrialization. The study was undertaken in two southern inland rivers in Edo State, Nigeria, following concerns that the increasing human population in the region, coupled with indiscriminate discharges into rivers could erode water quality and elevate metal concentrations above allowable limits. Water samples were collected and analyzed for heavy metal concentrations using standard procedures. The results showed that metal concentrations were generally within national and international limits for drinking water with exceptions in cadmium and lead. Water pollution indices showed metal pollution index for cadmium (1037, 757) and lead (503, 379) in Ovia and Ossiomo Rivers respectively. These values far exceeded the critical level of 100 with a high contamination index (>6) of cadmium in both rivers. Water quality index from physico-chemical analysis indicated poor conditions in Ossiomo River relative to very poor water conditions in Ovia River. The study demonstrated that cadmium and lead were the major contributors to the adverse environmental conditions in both rivers. Thus, incessant anthropogenic pressures adversely affected water quality of these rivers rendering them unsuitable for human use. This would potentially have serious ecological and human health implications as chronic effects may be unquantifiable.

Keywords: Ovia and Ossiomo Rivers, heavy metal, water quality index, contamination index
The Relationship between Employee Environmental Awareness and Current Environmental Management System
Authors: Goranczewski Boleslaw
Published: May 2021

Background. Many publications have studied environmental management systems. Once a system is implemented and maintained, it should affect employee environ­mental awareness – the question is to what extent it does so. To date, published studies have defined awareness and highlighted its importance. The author, as a practitioner, was interested in whether the positive opinion about the system expressed in the system documentation (audit reports) was relevant for the development of environmental awareness of managers and employees.

Research aims. Therefore, the purpose of this article was to establish the relationship between the state of the environmental management system and the environmental awareness of users. It was recommended to introduce surveys to raise awareness and improve the system.

Methodology. Literature review and surveys were used to collect the data.

Findings. The surveys showed that the vast majority of employees want their organization to be safe for the environment. But in practice, many employees do not know the environmental objectives or environmental improvement plans. This means that the system is not optimally maintained. Decision-makers rely on the reports from environmental audits and reviews to learn about the need to improve environmental awareness. In addition to analyzing the documentation, surveys are needed in an organization to understand the employees’ feedback.
Using the Concept of a Learning Organisation to Build a Third Generation University. Case Study of the Jagiellonian University
Authors: Madej Małgorzata , Stuss Magdalena M.
Published: May 2021

Background. Currently, the university management requires undertaking the execution of new activities. In response to the challenges of the contemporary processes of the management – building a third generation university - universities are adapting the concepts of management, which up to now have been first and foremost availed of in the sector of enterprises. Such a solution is the concept of a learning organisation.

Research aims. The aim of the research conducted was to verify the using of the concepts of a learning organisation during the building of the third generation university

Methodology. In the research methodology, a systematic literary review was applied, as well as a case study of the Jagiellonian University. The choice of this university was made on the basis of a subjective evaluation of the process of evolution of the university from the second generation to the third generation. The adoption of such research methodology shall facilitate the building of propositions of good practices of the university management for other universities in the future.

Findings. The research conducted reveals that the university has been usinga learning organisation to build a third generation university
PSYCHOLOGICAL AND PEDAGOGICAL ASPECTS OF FORMATION OF EMOTIONAL MATURITY OF A TEEN
Authors:   International Science Group, Bartienieva Iryna , Nozdrova Oksana
Published: May 2021

Proceedings Article published 2020 in THEORETICAL FOUNDATIONS FOR THE IMPLEMENTATION AND ADAPTATION OF SCIENTIFIC ACHIEVEMENTS IN PRACTICE
INTRA AND EXTRABUCCAL ASPECTS OF MIXED VASCULAR MALFORMATION IN CHILDREN
Authors:   Universidade Rio Verde, Longo Daniele Lucca , de Oliveira Fernanda Maria Machado Pereira Cabral ,   Universidade de São Paulo, Arnez Maya Fernanda Manfrin ,   Universidade de São Paulo, Martins Giovana Gonçalves ,   Universidade de São Paulo, de Queiroz Alexandra Mussolino ,   Universidade de São Paulo, Paula-Silva Francisco Wanderley Garcia ,   Universidade de São Paulo
Published: May 2021

Anomalias vasculares constituem distúrbios de células endoteliais que podem afetar capilares, artérias, veias e/ou sistema linfático. São classificadas como “tumores vasculares” ou “malformações vasculares”. As malformações vasculares são subdivididas em malformações capilares, linfáticas, venosas, arteriovenosas e mistas de acordo com o tipo de vasos afetados. O objetivo do presente estudo é relatar um caso de um paciente com malformação vascular mista (veno-linfática) e descrever o planejamento e o tratamento dentário realizado. O paciente do sexo masculino, 7 anos, foi encaminhado para avaliação odontológica. A mãe relatou que o ele estava em tratamento médico no hospital por apresentar “hemangioma e malformação vascular linfática” em região bucal. Durante o exame clínico, foi observada malformação vascular veno-linfática no assoalho oral. A criança relatou dificuldade para realizar a higiene bucal devido à lesão, sendo encontradas várias lesões de cárie. O tratamento odontológico consistiu em restaurações dentárias, selantes e exodontia de dentes decíduos. O tratamento da malformação vascular mista foi realizado com solução esclerosante (OK-432). A atenção à saúde bucal de pacientes com malformações vasculares deve incluir orientações de higiene bucal, escovação supervisionada e indicação do uso de escovas macias para evitar lesões nas áreas já afetadas.
MOSTRA DE TRABALHOS CIENTÍFICOS DO 8° EPCS: A CIÊNCIA PÓS-PANDEMIA
Authors:   Universidade Estadual de Maringá, Pedroso Raíssa Bocchi , de Andrade Luciano ,   Universidade Estadual de Maringá, Mikcha Jane Martha Graton ,   Universidade Estadual de Maringá, Jarros Isabele Carrilho ,   Universidade Estadual de Maringá, Milaré Áquila Carolina Fernandes Herculano Ramos ,   Universidade Estadual de Maringá, Nonose Daniele Stéfanie Sara Lopes Lera ,   Universidade Estadual de Maringá, Murase Letícia Sayuri ,   Universidade Estadual de Maringá, Pereira Elton da Cruz Alves ,   Universidade Estadual de Maringá, Fujikawa Olímpio Mutsuo ,   Universidade Estadual de Maringá
Published: May 2021

O Encontro do Programa de Pós-graduação em Ciências da Saúde (EPCS), que ocorre a cada dois anos é o principal evento de atualização científica organizado pelo Programa de Pós-graduação em Ciências da Saúde, da Universidade Estadual de Maringá. Atualmente, em sua oitava edição, o 8° EPCS deste ano teve como tema “Ciência pós-pandemia”. O objetivo do evento foi proporcionar aos participantes um ambiente científico de qualidade, além de estimular a troca de experiências e aprimoração de conhecimentos, durante todas as noites dos dias 17, 18, 19 e 20 de novembro de 2020.
Do paradigma da ineficiência da Lei nº 8.666 de 1993 à contratação baseada na eficiência –
Authors: Farias Rodrigo
Published: May 2021

O artigo propõe discutir de que maneira a contratação pública baseada na eficiência, em especial, em relação à possibilidade de ser estabelecida remuneração variável ao contratado, diante do atendimento de metas estabelecidas pela Administração Pública, ingressou no modelo brasileiro de licitações e contratos administrativos. A Lei Federal nº 8.666 de 1993, calcada, sob a literalidade de suas disposições, sob um sistema de remuneração fixa, demonstrou rapidamente sua pouca eficiência enquanto mecanismo de estímulo ao aumento da eficiência do contratado no cumprimento do objeto do contrato, o que não escapou de fortes críticas da doutrina. Do Projeto de Lei nº 1.292, apresentado no longínquo ano de 1995 e aprovado na Câmara dos Deputados no ano de 2019, passando pela Lei das PPP (Lei Federal nº 11.079 de 2004), pela criação do Regime Diferenciado de Contratações (RDC), por meio da edição da Lei Federal nº 12.462 de 2011, e pela Lei das Estatais (Lei Federal nº 13.303 de 2016) um longo caminho foi percorrido em prol deste novo modelo e, para o futuro, há novas e possíveis rotas possíveis de serem percorridas para tornar a contratação pública mais eficiente tomando a remuneração do contratado como instrumento para incrementar a performance da contratação pública.
A multiparentalidade no contexto das novas formações familiares e o entendimento da jurisprudência do Tribunal de Justiça do Estado do Rio de Janeiro
Authors: Pfister Gonçalves Isabela
Published: May 2021

Este artigo analisa o instituto da multiparentalidade na sociedade brasileira. Trata-se de fenômeno no qual oportuniza tanto ao pai biológico quanto ao pai afetivo a possibilidade de filiação em relação a prole a que estão afetivamente vinculados. Esta garante ao pai socioafetivo o prosseguimento do vinculo parental com o menor. A multiparentalidade surge em decorrência das modificações do atual arranjo familiar bem como da valorização do vínculo-sócio afetivo que agora o considera como um caminho possível para concessão da paternidade. Assim, o afeto construído entre pai e filho poderá resultar no deferimento do reconhecimento da paternidade, valendo ressaltar, contudo, que os vínculos biológicos continuam protegidos, pois a multiparentalidade na verdade busca atender ao melhor interesse da criança. Assim, a presente pesquisa terá perfil bibliográfico e empírico. A parte bibliográfica será construída através de revisão do posicionamento de autores que já versaram sobre o tema. Já a parte empírica investiga decisões oriundas do Tribunal de Justiça do Estado do Rio de Janeiro, no período de 2016 a agosto de 2019, apuradas no banco de dados do sistema virtual do Tribunal. Foram encontradas 37 decisões dentro do período investigado e se examinou os fundamentos que impulsionaram os juízes a fundamentarem suas sentenças. A multiparentalidade tem crescido a cada dia no âmbito das famílias e algumas delas já têm buscado a prestação jurisdicional a fim de regularizar a situação. Assim, já se observa uma tendência do judiciário em responder positivamente a esta atual demanda social. Os resultados demonstram que a multiparentalidade tem sido concedida sempre que comprovado o vínculo afetivo entre pai e filho, em atendimento ao princípio do melhor interesse do menor, sem, contudo, causar nenhum prejuízo ao vinculo biológico.
Exames complementares das entesopatias. Parte 1 – Biomarcadores
Authors: Lima Sônia Maria A. Anti Loduca , Yazbek Michel Alexandre
Published: May 2021

Biomarcadores são indicadores de processos biológicos normais, processos patogênicos ou respostas biológicas a determinada exposição ou intervenção, incluindo intervenções terapêuticas. Na reumatologia, e em especial nas espondiloartrites, numerosas pesquisas e publicações avaliam a contribuição dos biomarcadores na identificação de quadros precoces ou como marcadores de prognóstico e de progressão radiográfica e/ou mesmo na avaliação mais objetiva da resposta clínica a fármacos. Apesar disso, os resultados de muitos estudos ainda são conflitantes, são realizados em pequeno número de pacientes, e não apontam, até o momento, para a aplicabilidade da maioria destes biomarcadores em nossa prática clínica. Talvez isso não somente indique os múltiplos mecanismos etiopatogênicos implicados no desencadeamento deste grupo de doenças, mas também a diversidade de apresentações clínicas e de possíveis desfechos ao tratamento.

Unitermos: Biomarcadores. Biomarcadores séricos. Espondiloartrites. Espondilite anquilosante. Artrite psoriásica.
Nursing planning in complex pediatric neurosurgery procedures in a reference surgery center
Authors: Da Silva Allison Roberto
Published: May 2021

Surgical Centers are essential and extremely complex sectors in health institutions, where the teams that compose them must act together so that the main objectives are achieved: that is, the patients' surgeries happen in the best possible way, with the minimization of damages and welcoming patients and their families. The need for a multidisciplinary approach is intensified in surgeries with unique specificities, such as pediatric neurosurgeries, where problems are anticipated and interventions are performed before patients are harmed. The article is an experience report of the activities of the Nurse at the Surgical Center of a Large University Hospital in the interior of the state of São Paulo related to the planning and execution of pediatric neurosurgery procedures. The results include the description of direct and indirect care activities in nursing care planning, the nursing process, the main nursing diagnoses found in pediatric neurosurgery patients.
Modernização e segregação: a pesca artesanal no projeto nacional-desenvolvimentista
Authors: Cyrino Carolina de Oliveira e Silva
Published: May 2021

Resumo Este artigo analisa aspectos do processo de modernização da pesca no Brasil e sua relação com a segregação da atividade artesanal, durante a gestão da extinta Superintendência de Desenvolvimento da Pesca – SUDEPE, na década de 1970. Neste período, os ideais nacional-desenvolvimentistas alcançaram a economia nacional, e na política pesqueira fortaleceram-se através de estratégias de modernização da atividade e fomento às indústrias de pesca. Analisaremos algumas estratégias e discursos da SUDEPE - por meio de análise de documentos institucionais e dispositivos legais - no desenvolvimento de políticas modernizadoras que tinham como promessa a “evolução do setor pesqueiro”, entretanto, preterindo a atividade artesanal no projeto de desenvolvimento nacional. Palavras-chave: Nacional-desenvolvimentismo; Modernização; Política Pesqueira; Pesca artesanal. Abstract This work analyzes some of the modernization of fisheries process aspects in Brazil and their relation to the artisanal activity segregation, in the management of the former Superintendência de Desenvolvimento da Pesca – SUDEPE (Fisheries Development Superintendence), in the 1970s. During this period, the national-developmental ideal reached the national economy, and in the fishing policies, they get strengthened through modernization strategies and fishing industries fomentation. In this study, we will analyze some of the SUDEPE strategies and discourses - using the legislation and institutional documents – in the development of modernization policies that had the promise of a “fisheries evolution”, even if deprecating the artisanal fishing in the national development process. Keywords: National-developmentalism; Modernization; Fisheries Policy; Artisanal fishing. Resumen Este artículo analiza aspectos del proceso de modernización de la pesca en Brasil y su relación con la segregación de la actividad artesanal, durante la gestión de la extinta Superintendência de Desenvolvimento da Pesca - SUDEPE (Superintendencia de Desarrollo Pesquero), en la década de 1970. En este período, los ideales de desarrollo nacional alcanzaron la economía y la política nacional. En la actividad pesquera se fortalecieron mediante estrategias para modernizar y fomentar las industrias. Analizaremos algunas estrategias y discursos de SUDEPE - a través del análisis de documentos institucionales y disposiciones legales - en el desarrollo de políticas modernizadoras que tenían como promesa la "evolución del sector pesquero", sin embargo, descuidando la actividad artesanal en el proyecto de desarrollo nacional. Palabras clave: Nacional-desarrollismo; Modernización; Política pesquera; Pesca artesanal.
¿DEBEMOS REPENSAR LOS PODERES DEL JUEZ ANTE LA CONSTATACIÓN DE LA ILEGALIDAD DE UNA DISPOSICIÓN GENERAL O UN ACTO ADMINISTRATIVO? LA ANULACIÓN PARCIAL DEL PLAN GENERAL DE MADRID DE 1997: UN INMEJORABL
Authors: DEL SAZ CORDERO SILVIA
Published: May 2021

Con motivo de la anulación judicial de la desclasificación de los sectores
de suelo no urbanizable de protección operada por el Plan General de Madrid de 1997, este
trabajo plantea la necesidad de revisar los poderes del Juez contencioso administrativo
cuando constata la ilegalidad de una disposición o acto, los cuales no deben quedarse limitados
a la anulación sino, antes al contrario, deben tener en cuenta la situación jurídica o
fáctica existente cuando se dicta la sentencia, para evitar los efectos inútiles de una resolución
que obligue a la Administración a un esfuerzo inútil de reconstrucción o al mantenimiento
de la situación fáctica irreversible desplazando al incidente de ejecución la tutela de
los derechos intereses y derechos vulnerados mediante su compensación económica.

1997ko Madrileko Plan Orokorrak babes berezikotzat jotako lur urbanizaezinen
desklasifikazioaren baliogabetze judiziala dela eta, lan honek administrazioarekiko
auzien epailearen botereak berrikusteko beharra planteatzen du, xedapen edo egintza
bat legez kanpokoa dela egiaztatzen duenerako. Hala, ez dute dena delakoa deuseztatzera
mugatu behar, epaia ematen denean egoera juridikoa edo faktikoa zein den kontuan hartu
behar dute, halako moldez non Administrazioa ez den alferrik behartuko atzeraezina den
egoera faktiko bat berritzera edo horri eustera, eta urratutako interesen eta eskubideen babesa
epaia betearazteko intzidenterako utziko den, konpentsazio ekonomikoa emanda.

As a result of the judicial annulment of the de-classification of the land
protected from urban development by the General Plan of Madrid of 1997, this work shows
the need to check the powers of the contentitous administrative judges when verifying the
illegality of a provision or act, which cannot confine themselves to the annulment but also,
on the contrary, to take into account the legal or factual position that exists at the moment
of giving a judgment, in order to avoid useless effects of a resolution that obliges the
Administration to a useless effort of rebuilding or to keep an irreversible factual situation
moving to the execution the protection of interests and infringed rights by means of an
economic compensation.