bluuebunny/crossref_metadata_2025 huggingface dataset:
SPHERICAL SPLINE SOLUTIONS OF THE INHOMOGENEOUS BIHARMONIC EQUATION
Authors: Vaskevich V. L
Published: December 2024

An inhomogeneous biharmonic equation is considered on the unit sphere in three-dimensional space. The solution of this equation, belonging to the Sobolev space on the sphere, is approximated by a sequence of solutions of the same equation but with specific right-hand sides, represented as linear combinations of shifts of the Dirac delta function. It is proven that, given specified nodes on the sphere determining the shifts, special solutions of the equation — spherical biharmonic splines — exist, and the weights corresponding to each are solutions of an associated non-degenerate system of linear algebraic equations. The connection between the approximation quality of the differential problem solution by spherical biharmonic splines and the problem of the convergence rate of optimal weighted spherical cubature formulas is established.
ENERGY ESTIMATES FOR A CLASS OF PSEUDO-HYPERBOLIC OPERATORS WITH VARIABLE COEFFICIENTS
Authors: Demidenko G. V
Published: December 2024

A class of strictly pseudo-hyperbolic fourth-order operators with variable coefficients is considered. Energy estimates are established under certain conditions on the coefficients. These estimates imply the uniqueness of the solution to the Cauchy problem, as well as a priori estimates.
SCHEME FOR CALCULATING UNSTEADY FLOWS OF HEAT-CONDUCTING GAS IN A THREE-TEMPERATURE APPROXIMATION
Authors: Zhukov V. T , Feodoritova O. B
Published: December 2024

A numerical modeling technique for unsteady flows of heat-conducting gas in a three-temperature approximation is presented. The methodology is based on the foundational principles of S.K. Godunov. For time integration, each time step is computed by splitting the governing equations into hyperbolic and parabolic subsystems. The first subsystem is solved using a generalized Godunov scheme, while the second uses an explicit-iterative Chebyshev scheme. Adaptive, curvilinear moving grids are used for discretization, and the discrete scheme is formulated in curvilinear coordinates, preserving the symmetries of the differential problem. The methodology is implemented as a parallel code for multiprocessor computers. Its primary purpose is to support computational studies in controlled thermonuclear fusion, though it can also be applied to other areas of computational aerogas dynamics.
CLASSIFICATION OF THE QUASILINEAR SYSTEMS OF ORDINARY DIFFERENTIAL EQUATIONS AND ITS APPLICATION FOR NORMALIZATION OF SYSTEMS IN CRITICAL CASE OF BOGDANOV–TAKENS
Authors: Basov V. V.
Published: December 2024

Two-dimensional autonomous system with a quasihomogenous polynomial of a first degree and weight (1, 2) in an unperturbed part is considered. The classification of an unperturbed parts is provided. According to it, the set of polynomials is constructively divided into eight equivalence classes with respect to quasihomogenuos zero degree substitutions. In each class the respresentatives, called the canonical forms, are determined. All structures of the generalized normal forms for the so far unstudied system with one of the canonical forms in its unperturbed part are obtained. Normalization in the system with unperturbed part (𝑥2, 𝑎𝑥1𝑥2+𝑏𝑥31) is performed using method of the resonant equations and sets. This significantly improves the already obtained results of the research in one of the critical cases of Bogdanov–Takens classification.
STUDY OF PARAMETER SPACE OF MULTIDIMENSIONAL SYSTEM WITH RELAY HYSTERESIS AND PERTURBATION
Authors: Yevstafyeva V. V. , Guseva M. Yu.
Published: December 2024

The object of research is an 𝑛-dimensional system of ordinary differential equations that contains a constant diagonal matrix with real eigenvalues, two-position relay nonlinearity of hysteresis type with a parameter and a continuous periodic perturbation function with a parameter. In the case of a special type of feedback vector (one non-zero element), we obtain conditions for system parameters that ensure the existence of a unique two-point oscillatory periodic solution with a period multiple of the perturbation function period. We establish a functional dependence of the nonlinearity parameter on the perturbation function parameter. Influence of perturbation function parameter values on the existence of the solution is investigated. We offer an algorithm for seeking system parameters and the instant of the first relay switching in the case when the solution period is given. Theoretical results, including the proposed algorithm, are illustrated by the example of a three-dimensional system.
ON SENSITIVITY OF SOLUTIONS OF RICCATI EQUATIONS UNDER SMALL PARAMETER PERTURBATIONS AND OPTIMALITY IN LINEAR STOCHASTIC CONTROL SYSTEMS
Authors: Palamarchuk E. S.
Published: December 2024

We investigate sensitivity of solutions of Riccati equations under asymptotically small perturbations of their coefficients. Upper bound on the difference between solutions of algebraic and differential Riccati equations is derived. The result is applied to study optimality in the stochastic linear-quadratic control problem over an infinite time-horizon for an asymptotically autonomous system. We also treat an issue related to performance of invariant control strategy.
ON THE STABILITY BY THE NONLINEAR NON-STATIONARY HYBRID APPROXIMATION
Authors: Platonov A. V.
Published: December 2024

The paper investigates the effect of non-stationary perturbations on the stability of nonlinear nonautonomous systems with switching and impulsive effects. Sufficient conditions have been obtained to guarantee the asymptotic stability of a given equilibrium position of the initial system, and restrictions have been established under which the asymptotic stability is preserved under perturbations acting on the system. Note that the non-stationarities present both in the system itself and in perturbations can be described by unbounded functions with respect to time, as well as functions arbitrarily close to zero. It is assumed that the basic system is homogeneous in terms of the state vector. To find the required results, the second Lyapunov method is used in combination with the theory of differential inequalities.
BOUNDARY PROBLEM FOR THE LAPLACE EQUATION WITH MIXED BOUNDARY CONDITIONS IN A SEMIBAND
Authors: Kapustin N. Y. , Vasilchenko D. D.
Published: December 2024

Theorems on the existence and uniqueness of the solution to the Laplace equation with mixed boundary conditions in a semiband have been proven in the work. Additionally, integral representations for the partial derivatives of the solution have been obtained.
Manganese Silicide-Germanides Anodic Behavior in Sodium Sulfate Aqueous Solution: Influence of Germanium Content
Authors: Rakityanskaya I. L. , Myasnikov D. A.
Published: December 2024

The anodic electrochemical behavior of manganese silicide-germanides with different ratios of germanium and silicon was studied using voltammetry and impedance spectroscopy methods in a 0.5 M sodium sulfate aqueous solution. It has been shown that the resistance of materials to oxidation decreases with increasing proportion of germanium, which, unlike silicon, is not capable of forming a layer of stable oxides on the surface of the material.
Kinetics of Electrooxidation of Dimethyl Sulfoxide on a Platinum Electrode with Sulphuric Acid and Alkaline Solutions
Authors: Ibragimova K. O. , Khidirov Sh. Sh. , Suleymanov S. I.
Published: December 2024

In this work, an electrochemical study of the mechanism of electrooxidation of dimethyl sulfoxide (DMSO) on a platinum electrode in acidic and alkaline solutions was carried out. On stationary polarization anodic curves taken within DMSO in an acidic and alkaline environment, the processing currents are processed manually than in dissolved light. When analyzing linear sections of anodic voltammograms, the values of the coefficients of the Tafel equation were achieved. This definition defines the current density measurement range and conditions for the electrooxidation of DMSO on a platinum (Pt) electrode. Electrolysis was carried out at controlled current densities in an electrolyzer without separation and with separation of the anode and cathode compartments using MK-40, MA-40 membranes and a fluoropolymer sulfcationite membrane MF-4SK. The high electrical conductivity and selectivity of the membranes ensures good performance of the electrolysis process and obtains a high-purity final product. Raman spectroscopy and gas chromatography-mass spectrometry have confirmed that the products of DMSO electrooxidation in an acidic environment are dimethyl sulfone (DMSO2) and methanesulfonic acid (MSA), and in an alkaline environment DMSO2 and sodium methanesulfonate. The method of quantum chemical calculations showed good adsorption of DMSO molecules on platinum within the framework of the cluster model. It has been established that the formation of MSA on the surface of a platinum electrode at high current densities occurs via the radical ion mechanism, by breaking the C–S bond. Based on the experimental results obtained, a scheme for the electrochemical oxidation of dimethyl sulfoxide on platinum is proposed.
Neostructural zoning and hazardous processes in the Chara rift basin
Authors: Nesmeyanov S. A. , Sergeev D. O. , Voeykova O. A. , Kulakov A. P.
Published: December 2024

Routine distinguishing of morphostructures upon neotectonical studies in the Chara rift area is supplemented by the orotectonic method. This combination permitted us to characterize the phases and unevenness of orogenesis and faulting along the regional normal fault. The instability of Mesozoic and recent structure formation is revealed, as well as the Neo-Pleistocene activation of the structures known in Alpine orogens. It is shown that the structurally dependent features of the relief control the specifics of exogenous geohazards manifestation. Using the tectonic method, the established patterns may also be valid for other rifts in the Baikal Rift Zone.
The impact of mine blasting on the occurrence of human-induced tectonic earthquakes in the eastern Orenburg region
Authors: Nesterenko M. Yu. , Belov V. S. , Galeeva E. R.
Published: December 2024

The geodynamic situation is analyzed in the area of the eastern Orenburg region for 2006-2022. The number of recorded seismic events averages 742 events per /year. The impact of mining works on the increase of technogenic seismicity is considered. It is established that most of seismic events occur in the territories near the developed mineral deposits. The technogenic earthquakes with a magnitude Ml 3.0 were analyzed. The reasons of intensifying technogenic-tectonic seismicity are revealed. The specific features of strong (Ml ≥ 3.0) technogenic-tectonic earthquakes under the dynamic effects of blasting operations upon mining are described. The time dependence between the explosions carried out at industrial sites and the recorded seismic events (correlation coefficient 0.89) is found. The types of technogenic seismicity, static and dynamic, are considered. Recurrent dynamic impacts of blasting operations can trigger the stress state discharge in tectonic structures. Geodynamic events with magnitude Ml ≥ 4.0 exert the most hazardous impact on industrial and civil buildings and structures; they also affect the environmental situation in the region and the population safety. The zoning of territory was carried out, and two separate areas were distinguished with an elevated number of recorded seismic events with a magnitude of Ml 3.0, i.e., Adamovsky and Yasnensky districts.
Assessment of geological environment for the territorial scheme of municipal solid waste management
Authors: Kozliakova I. V. , Eremina O. N. , Romanova E. R. , Khairedinova A. G. , Chutkerashvili E. S.
Published: December 2024

The current trends in the municipal waste management development are considered and the problems in using spatial geological data are shown, which consist in the complexity of combining geological information with other data in the waste management system. A methodological approach is proposed to take into account the geological environment specifics in the territorial scheme of waste management on the basis of digital mapping by the example of the Moscow region. An assessment zoning of a representative key site was carried out in the QGIS program according to its suitability for the municipal solid waste disposal depending on the presence of low-permeable soils and rocks in the geological section.
CONSTRUCTION OF SMOOTH “SOURCE-SINK” ARCS IN THE SPACE OF DIFFEOMORPHISMS OF A TWO-DIMENSIONAL SPHERE
Authors: Nozdrinova Е. V. , Pochinka О. V. , Tsaplina E. V.
Published: December 2024

It is well known that the mapping class group of the two-dimensional sphere 𝕊2 is isomorphic to the group ℤ2 = {−1, +1}. At the same time, the class +1 (−1) contains all orientation-preserving (orientationreversing) diffeomorphisms and any two diffeomorphisms of the same class are diffeotopic, that is, they are connected by a smooth arc of diffeomorphisms. On the other hand, each class of maps contains structurally stable diffeomorphisms. It is obvious that in the general case, the arc connecting two diffeotopic structurally stable diffeomorphisms undergoes bifurcations that destroy structural stability. In this direction, it is particular interesting in the question of the existence of a connecting them stable arc ”— an arc pointwise conjugate to arcs in some of its neighborhood. In general, diffeotopic structurally stable diffeomorphisms of the 2-sphere are not connected by a stable arc. In this paper, the simplest structurally stable diffeomorphisms (“source-sink” diffeomorphisms) of the 2-sphere are considered. The non-wandering set of such diffeomorphisms consists of two hyperbolic points: the source and the sink. In this paper, the existence of an arc connecting two such orientation-preserving (orientation-reversing) diffeomorphisms and consisting entirely of “source-sink” diffeomorphisms is constructively proved.
ANALYTIC METHOD FOR SOLVING ONE CLASS OF NONLINEAR EQUATIONS
Authors: Popkov Yu. S.
Published: December 2024

The paper proposes an analytical approximate method for calculating multidimensional integrals of analytic integrand functions, using the approximation of the latter by a power series. This approach lets transforming the original system of nonlinear equations with integral components into a system of equations with a polynomial left-hand side. To solve equations of this class we developed an analytical method. A sequential recurrent procedure has been developed for the analytical solution of this class of nonlinear equations.
CONCERNING ONE SUPPLEMENT TO UNIFICATION METHOD OF N.N. KRASOVSKII IN DIFFERENTIAL GAMES THEORY
Authors: Ushakov V. N. , Tarasyev A. M. , Ershov A. A.
Published: December 2024

The paper deals with the game problem of approach for a conflict-controlled system in a finite-dimensional Euclidean space at a fixed moment of time. The problem of approximate calculation of the solvability sets is studied for the considered approach game. An approach is proposed for approximate calculation of solvability sets on the basis of a unification model, which supplements the unification method of N.N. Krasovskii in the theory of differential games.
INFOBUSINESS AS A NEW DIGITAL PHENOMENON IN THE SOCIO-ECONOMIC SPHERE OF RUSSIA: POSSIBILITIES OF MODELING AND REGULATION
Authors: Voronov A. S. , Orlova L. N. , Shamolin M. V.
Published: December 2024

Digital technologies are known to have high potential for economic growth, to promote social and political communications. They are platforms for the implementation of new business ideas. New digital phenomenon ”— the information business ”— is investigated in the article. How does information business affect the economy and society? This question determines the main topic for discussion. The following methods were used in the article: system analysis, content analysis, sociological survey, comparative analysis, cluster analysis, fuzzy logic methods, mathematical modeling. The purpose of the article is to determine the relationship and spread of new digital technologies and phenomena in the socio-economic and political spheres of Russia. There are such results as recommendations on the transformation of socio-economic relations, modeling and state regulation of processes in the information environment in the article. At the same time, mathematical methods for studying the tasks are proposed.
PUSHKIN IN THE SAINT SOPHIA CATHEDRAL IN KYIV Concerning the Key Scene of Ivan Novikov’s Novel “Pushkin in the South”
Authors:   Princeton University, Vinitsky Ilya
Published: December 2024

The article considers a central episode
in Ivan Novikov’s popular biographical
novel Pushkin in the South (1943—
1944), which portrays the poet’s vision in
the St. Sophia Cathedral in Kyiv. According to the novelist’s hypothesis, this
vision is closely associated with Pushkin’s
“secret love” and represents the main
source of the poet’s erotic narrative poem
The Gavriiliad. The article analyzes the
ideological implications of the scene and
reconstructs the sources of this biographical mystifi cation in the context of Novikov’s oeuvre, Russian Symbolism of the
1900s and Russian debates on Pushkin
of the 1920s—1940s
SO WHAT TURNS BLACK THROUGH TATYANA LARINA’S SHIRT? Textological problems in one epigram by Pushkin
Authors:   The Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences, Kitanina Tatyana Alexandrovna
Published: December 2024

The note focuses on the problem
of choosing the text source of Pushkin’s
epigram “The navel turns black through
the shirt...”. This epigram in the Complete Works is printed according to an
authoritative copy from the manuscript
collection of S. Sobolevsky “Avant les
voyages”, but its fi rst verse, which coincides with Sobolevsky’s version in all
known copies, is corrected according to
the text from the memoirs of M. Pushchin, who owned once an autograph, but
then lost it and reproduced the text from
memory many years later. The note provides arguments in favor of the correctness
of this solution, although it is by no means
obvious.
Теоретичні уявлення про міжнародні відносини і дипломатію автора «Історії русів» (початок ХІХ ст.)
Authors: Ластовський Валерій
Published: December 2024

Мета дослідження полягає у необхідності розглянути політичні погляди автора «Історії русів», що сформувалися на початку ХІХ століття, в яких містяться уявлення про міжнародні відносини і дипломатію. Цей твір є частиною українського політичного процесу і створений у нових умовах розвитку українських земель, що почали формуватися після ліквідації Гетьманщини та Запорозької Січі у ХVІІІ ст. Міжнародні відносини і дипломатичні стосунки на сторінках «Історії русів» стають частиною розвитку української державності. Доводиться, що автор більше уваги приділяє безпосередньо дипломатичній практиці і тільки деякою мірою причинам війн та проблемам мирних відносин. Найбільше зауважується на подіях, пов’язаних із Українською національною революцією та епохою Руїни, коли українська дипломатія була найбільш активною на теренах Східної Європи. При цьому для автора видатною особистістю в українській дипломатії виступав гетьман Богдан Хмельницький. На основі його діяльності на міжнародній арені, у стосунках із європейськими країнами, і утверджується суб’єктність Війська Запорозького. Також зауважується і на використанні українською дипломатією різноманітних прийомів і засобів для вирішення своїх проблем на міжнародній арені. Методологія дослідження заснована на системності, застосуванні методів аналізу, логіки та порівняння. За їх допомогою вдалося проаналізувати погляди автора «Історії русів», визначити їх особливості стосовно поглядів інших дослідників. Висновки дослідження засвідчують невід’ємність теоретичних уявлень про міжнародні відносини і дипломатію в «Історії русів» невідомого автора та їх зв’язок із уявленнями української еліти попередніх десятиліть і вплив на українську політичну думку більш пізнього періоду.
ЦИФРОВА ТРАНСФОРМАЦІЯ МІЖНАРОДНОГО МАРКЕТИНГУ
Authors: БУЯК Леся , СЕМЕНЕНКО Юрій
Published: December 2024

Сучасна маркетингова діяльність грунтується на використанні великих обсягів даних про клієнтів для створення персоналізованих пропозицій і підвищення точності таргетингу. Одним із основних методів аналізу даних є кластеризація, що дозволяє сегментувати споживачів на основі їхніх характеристик та поведінкових закономірностей. В статті досліджуються особливості застосування кластерного аналізу для побудови портрету клієнта та розглядаються практичні аспекти його впровадження у маркетингові процеси.
У статті представлено теоретичні основи кластеризації. Розглянуто ключові алгоритми кластерного аналізу, які найчастіше використовуються в маркетингу, ієрархічну кластеризацію та методи, засновані на щільності. Кожен із цих підходів аналізується з позиції його придатності для різних маркетингових задач, таких як сегментація ринку, аналіз поведінки споживачів та персоналізація обслуговування.
Досліджуються етапи побудови портрету клієнта. Розглянуто процес збору, підготовки та відбору даних, демографічні дані, частота покупок, обсяг витрат та канали взаємодії. Досліджено важливість релевантних характеристик для формування сегментів, що допомагають визначити ключові закономірності поведінки кожного кластеру клієнтів. Розглянуто, як використання алгоритмів кластеризації дозволяє автоматизувати процеси аналізу та оптимізувати роботу з великими масивами даних.
У статті розглянуто застосування кластерного аналізу на прикладі роботи з програмним забезпеченням. Описано, як маркетологи можуть реалізувати кластеризацію клієнтських даних за допомогою таких інструментів, як Python або спеціалізованих CRM-системи або аналітичні платформи, які дозволяють інтегрувати методи кластеризації для швидкої обробки та інтерпретації результатів. Досліджено візуалізацію даних, що сприяють аналізу отриманих кластерів та дозволяють визначити відмінності між сегментами клієнтів на рівні доходів, частоти покупок та інших характеристик.
Розглянуто прикладні аспекти використання кластеризації в маркетингових стратегіях, таких як розробка персоналізованих рекламних кампаній, оптимізація асортименту продукції для конкретних груп клієнтів, підвищення ефективності комунікацій та створення програм лояльності. Кластеризація дозволяє формувати точніші портрети клієнтів, що відкриває можливості для реалізації персоналізованих підходів і допомагає маркетологам краще зрозуміти потреби кожного сегменту.
Також досліджено можливі проблеми, пов’язані із збором якісних даних, високими вимогами до обчислювальних ресурсів для роботи з великими масивами інформації та етичними аспектах захисту персональних даних.
Chronic obstructive pulmonary disease (COPD): New treatment and management approaches
Authors: Bhoyar Vikas , Suryawanshi Vishwajit , Kanya Deepika
Published: December 2024

COPD is the third leading cause of morbidity and mortality from chronic diseases worldwide, and exposure to toxic particles, such as tobacco smoke and air pollution, is the first risk factor. The management of symptoms advances with the prevention of acute relapse rather than the loss of preciosity in the early stages of the disease. Current therapies focus mainly on the alleviation of symptoms and lack intervention in the underlying inflammatory mechanisms responsible for tissue destruction in the lungs and airway obstruction. In this context, there has been an explosion of advances in omics and imaging technologies that will shed light on the pathobiology of COPD, leading to better methods for its diagnosis, treatment, and prevention. In addition, novel biomarker-based approaches also allowed for better patient stratification, which led to the reappropriation of existing drugs for more personalized care in specific patient populations. The coronavirus pandemic has further aggravated the situation of COPD patients. This is because, by nature, COPD patients are more prone to severe forms of respiratory illness. They added the burdens of social isolation and disrupted healthcare services, further complicating disease management. Components of a strategy for COPD burden reduction are early diagnosis, proper management of comorbidities, promotion of regular physical activity, vaccine interventions, and other smoking cessation programs. It is crucial to fight tobacco use, minimize exposure to environmental risk factors at all levels and increase access to healthcare. Another way to reduce COPD is also important in areas where there are alternatives to biomass fuels, thus reducing the burden on COPD rates. This can otherwise minimize the long-term impact.
Exploring inclusion in the public sphere: A comprehensive systematic review
Authors: Maifianti Khori Suci , Sarwoprasodjo Sarwititi , Kinseng Rilus A. , Sadono Dwi
Published: December 2024

This research explores the importance of public space as an important communication arena in supporting democracy and community participation. By adopting the systematic literature review (SLR) method, this study analyzed 38 articles published between 2014 and 2024, related to public communication and the dynamics of public space. The results of the study show that public spaces, both traditional and digital, play an important role in facilitating dialog and citizen participation. This article highlights the challenges facing digital public spaces, such as disinformation and polarization, and emphasizes the importance of education and political awareness to increase citizen engagement. In addition, factors influencing the ideal speech situation (ISS) in public spaces were identified, including culture, access, and equality. This research contributes to a deeper understanding of how public spaces can be optimized as a means to encourage active community participation in decision-making processes and inclusive social development. The findings of this study are expected to provide recommendations for policymakers and activists in the field of public communication to create a more inclusive and effective public space, as well as support the sustainable development goals (SDGs).
Navigating tomorrow's healthcare: Exploring the future of healthcare navigation with VR, AR, and emerging technologies: A comprehensive review
Authors: Jallah John Kessellie , Kanyal Deepika , Lalwani Lajwanti , Flahn Stella T. L , Dweh Tuward J.
Published: December 2024

Effective navigation is critical to optimizing patient outcomes and improving the patient experience in today's rapidly growing healthcare landscape. The potential influence of VR, AR, and other emerging technologies on healthcare navigation is examined in this article. Patients may meet medical experts, participate in their treatment plans, and better apprehend their conditions through the immersive adventures offered by virtual and augmented reality. In addition to augmented and virtual reality, wearable technologies, AI, and the IoT are transforming real-time health monitoring and customization, augmented reality, virtual reality, and healthcare navigation. This study synthesizes the literature, examines case studies, and looks at real-world scenarios to provide insights into the potential, difficulties, and opportunities of utilizing these technologies to develop a patient-centric healthcare system. Academic databases were examined, including PubMed, Google Scholar, IEEE, and other relevant public health, medicine, and healthcare technology journals. The data gathered from case studies, actual-life scenarios, and literature reviews is synthesized to provide a comprehensive overview of the current landscape, opportunities, challenges, and prospects of leveraging VR, AR, and emerging technologies in healthcare navigation, including key terms such as emerging technologies, VR, AR, and healthcare navigation. The main discussion topics are targeted treatment, data visualization, medical research, and virtual and augmented reality. Additional worries are raised about privacy, data security, and ethical ramifications. Though these technology has some exciting aspects, problems like unequal access and technical constraints must be overcome before it can be extensively used. In order to overcome these obstacles and pave the way for a more effective, patient-centered healthcare system, virtual reality, augmented reality, and other cutting-edge technologies may be used to reform healthcare navigation.
Sustainable biomaterials for pharmaceutical and medical applications
Authors: Weerarathna Induni Nayodhara , Kumar Praveen , Luharia Anurag , Mishra Gaurav
Published: December 2024

The utilization of sustainable biomaterials in pharmaceutical and medical applications has gained significant momentum in recent years due to their dual ability to address environmental concerns and meet the evolving demands of modern healthcare. As the need for greener alternatives in healthcare intensifies, this review presents a comprehensive overview of recent advancements and innovations in sustainable biomaterials for pharmaceutical and medical fields. The review begins by exploring sustainable sourcing methods and eco-friendly production techniques, which are crucial in reducing the environmental footprint of biomaterial development. Emphasis is placed on adopting renewable resources and processes that minimize waste and energy consumption, ensuring sustainability throughout the lifecycle of these materials. A diverse array of sustainable biomaterials is highlighted, including biopolymers, natural extracts, and biobased nanoparticles, with a focus on their unique properties and biomedical applications. These materials are increasingly utilized in critical areas such as drug delivery systems, tissue engineering, wound healing, and medical device fabrication. Their attributes, including biocompatibility, biodegradability, and therapeutic efficacy, make them valuable assets in advancing healthcare solutions while preserving environmental integrity. Additionally, this review delves into regulatory considerations and the commercialization prospects of sustainable biomaterials, discussing the challenges and opportunities in integrating these materials into mainstream medical and pharmaceutical practices. Issues such as cost-effectiveness, scalability, and adherence to stringent regulatory standards are critically examined to understand their implications for real-world applications. By elucidating the potential, challenges, and future directions of sustainable biomaterials, this article aims to inspire further research and innovation in developing environmentally friendly and effective healthcare solutions. It advocates for a transformative approach to material science that prioritizes sustainability without compromising therapeutic outcomes, paving the way for a greener and healthier future.
Cluster analysis of learning styles and ICT competence: Towards a typology of flexible learners in higher education
Authors: Nozaleda Bryan M. , Dayag-Tungpalan Maricel L. , Arao Hans Freyzer B. , Ramos Chita C.
Published: December 2024

This study explores the intersection of students' learning styles and their Information and Communication Technology (ICT) competence within a flexible learning environment, focusing on the academic experiences at Cagayan State University-Carig Campus. Conducted during the 2020-2021 academic year, the research surveyed 686 first- and second-year students to gain a nuanced understanding of how learning styles and ICT skills interact in flexible learning settings. The study employed the Grasha-Riechmann Student Learning Styles Scale (GRSLSS) and a specially designed ICT Competence Scale to achieve its objectives. These included describing students' learning styles and ICT competence, deriving a tailored factor structure for the GRSLSS within flexible learning contexts, and classifying students into distinct profiles based on these variables. Using exploratory factor analysis, the GRSLSS was adapted to better reflect the flexible learning environment. Subsequently, K-means cluster analysis identified three distinct learner profiles. The first, "Purposeless Learners," represents students with very low ICT skills and engagement, struggling to navigate flexible learning. The second profile, "Versatile Learners," includes students with moderate to high ICT competence who excel in both collaborative and independent learning contexts. The third, "ICT Savvy Engagers," comprises students with high ICT proficiency who prefer collaborative, non-competitive approaches to learning.This typology provides valuable insights into how students adapt to flexible learning modalities, emphasizing the critical role of ICT in shaping modern education. The study underscores the importance of developing tailored pedagogical strategies that accommodate diverse learner profiles. It recommends expanding the sample size, conducting confirmatory factor analyses, and refining assessment tools to further validate and contextualize the findings, ultimately contributing to more effective flexible learning frameworks.
The role of AI in enhancing hospital operational efficiency and patient care
Authors: Suryawanshi Vishwajit , Kanyal Deepika , sabale Shantanu , Bhoyar Vikas
Published: December 2024

Artificial intelligence is changing the way hospitals work by being more efficient and patient-centric. This paper explores how AI technologies, such as machine learning and natural language processing, are integrated into healthcare systems to optimize data management, diagnostics, and personalized medicine. Applications driven by AI streamline workflows, facilitate clinical decision-making, and mitigate human error, thereby improving patient outcomes. Some of the key operational efficiencies that can be facilitated by AI include predictive analytics for better resource allocation, automated scheduling to minimize wait times, and supply chain optimization for effective delivery of medical services.The paper describes how the use of AI is instrumental in transforming patient care through a diagnostic precision, personalized medicine and remote monitoring. The use of ML-algorithm powered diagnostic tools increases image and pattern recognition accuracy through early and accurate detection. Personalized medicine is delivered through AI's capability to personalise treatment plans for individualised patient profiles to improve care outcomes. Remote monitoring of the patient can be done at real-time by using complex sensors and telecommunication tools regarding chronic and critical conditions.Despite these gains, integration barriers, concerns about bias and privacy, and the need for extensive education of healthcare professionals remain. In conclusion, the study emphasizes further innovation and interdisciplinary collaboration toward harnessing the full power of AI in healthcare.This paper also outlines future directions, emphasizing AI's capacity to revolutionize healthcare with advancements in analytics, intelligent hospital frameworks, and clinical research. By aligning technical innovation with ethical considerations, AI promises to create a smarter, patient-centric healthcare ecosystem. The findings advocate for strategic adoption of AI technologies to achieve enhanced operational efficiency, cost reduction, and superior patient care.
Gamification elements and their impacts on education: A review
Authors: Jun Mao , Lucas Terry
Published: December 2024

Gamification, the integration of game design elements in non-gaming contexts, has emerged as a popular strategy across various disciplines, particularly in education. This meta-analysis evaluates the impact of gamification on student engagement, motivation, and academic performance from 2021 to 2024. A systematic review was conducted following PRISMA principles, analysing studies sourced from major academic databases, including ScienceDirect, Google Scholar, and Scopus. Peer-reviewed publications focusing on gamification elements such as badges, leaderboards, and points were prioritized. Findings indicate that gamification significantly enhances student motivation, active participation, and academic success. Specific features like badges and leaderboards foster competitiveness and recognition, which are essential for promoting self-regulation and active learning. Points systems, on the other hand, provide immediate feedback and measurable goals, enabling learners to track progress effectively. Collectively, these elements create dynamic, interactive, and enjoyable learning environments that facilitate deeper engagement and comprehension. This review also highlights the diversity of gamified approaches tailored to educational settings, demonstrating their adaptability to various subjects and age groups. The implementation of gamification has been shown to bridge gaps in traditional pedagogical methods by introducing novel ways of capturing student interest and sustaining long-term involvement. However, the effectiveness of gamification is contingent on careful design and alignment with instructional objectives. Overall, the findings underscore the transformative potential of gamification in education. By integrating game mechanics into learning processes, educators can cultivate intrinsically motivated learners and foster improved academic outcomes. The study concludes with recommendations for future research to explore the longitudinal effects of gamification and its applicability across diverse educational contexts.
Prevalence and patterns of anxiety, depressive, hyperactivity, and inattention symptoms among secondary and high school students: A cross-sectional study
Authors: Dao Duc Minh
Published: December 2024

This study aimed to examine the prevalence of anxiety, depression, hyperactivity, and inattention symptoms among secondary school and high school students. The research specifically focused on understanding the status of these mental health symptoms in the adolescent population. This cross-sectional study involved 529 students (40.5% males, 59.5% females) aged 12--18 years who were selected via a convenience sampling method from various secondary and high schools. Four separate questionnaires were developed to measure anxiety, depression, hyperactivity, and inattention symptoms via a 4-point Likert scale. Descriptive statistics were applied to analyze the data. The findings indicated that anxiety, depression, hyperactivity, and inattention symptoms were generally low, with overall mean scores falling at the "Never" level for most symptoms. However, some symptoms, particularly inattention, were present at the "sometimes" level, suggesting occasional challenges in focus and concentration. Anxiety symptoms, such as difficulty concentrating and persistent worry, were also notable. Depressive symptoms, such as self-criticism and sadness, although less common, were observed. While severe mental health symptoms are not consistently observed, the presence of certain anxiety, depression, and inattention symptoms suggests the need for early intervention. Schools should implement mental health support programs to address these occasional symptoms, which can affect academic performance and overall well-being.
The relationship between organizational culture and digital transformation in SMEs: A systematic review
Authors: Baojing Zhou , Alias Norazlan , Yaacob Mohd Hasimi
Published: December 2024

This paper presents an organised and thorough review of empirical research about the relationship between organization culture (OC) and digital transformation (DT) in SMEs (small and medium-sized enterprises) from 2018 to 2024. This literature overview includes 26 articles published in Scopus as well as Web of Science (WOS) journals, along with additional records identified from other sources. In accordance with PRISMA standards, this review presents the results in a standardized format. Our findings indicate a substantial impact of OC on DT initiatives, while simultaneously demonstrating that the DT process alters OC, creating a dynamic feedback loop. However, it is noteworthy that some studies have found no significant correlation between OC and DT. This review highlights that most research focuses on cross-sectional studies and conceptual models based on theoretical frameworks. The reviewed literature encompasses a diverse geographical range, including studies from developed and developing countries. Key factors facilitating or hindering DT in SMEs are identified, including open-mindedness, innovation orientation, digital culture, change readiness, cooperation, risk tolerance, leadership commitment, and customer-centricity. The study underscores the need for culturally tailored strategies and models to support SMEs’ DT journey. Research gaps are identified, particularly regarding the consequences of DT on OC in the long run among SMEs and industry-specific variations in the OC-DT relationship. Future studies should explore longitudinal designs, incorporate diverse sector contexts, and delve into the influences of leadership in this evolution.
Relationship between grading of invasive ductal breast carcinoma at RSPAL Dr. Ramelan Surabaya and tumor infiltrating lymphomocytes (TILs) period January 2020–December 2022
Authors: Sukmana Judya , Octavianda Yohana , Putra Andra Kusuma , Nefertiti Eva Pravitasari , Aziz Duti Sriwati , Dewi Lestari , Rahayu Indri Ngesti , Husodo Stefanus Djoni
Published: December 2024

Worldwide, including in Indonesia, breast carcinoma is the most frequent form of cancer among women. Out of 396,914 cancer patients in Indonesia, 68,858 (16.6%) were diagnosed with breast cancer. An essential component of the immune response to cancer, Tumor Infiltrating Lymphocytes (TILs) are receiving more and more attention in studies on breast carcinoma. Groups of immune cells, including T lymphocytes, are discovered in tumor tissue and are referred to as TILs. Prognostic information can be gleaned from TIL existence, composition, and activity, according to substantial evidence. Grading, shows the degree of tumor aggressiveness and is crucial for treatment planning, is an essential part of breast cancer. We still do not completely understand the significance of TILs in deciding grading of invasive ductal carcinoma, one of the most common kinds of breast carcinoma. We set out to document the correlation between TILs and invasive ductal breast cancer grading from 2020 to 2022. The study used a retrospective cross-sectional analysis as its methodology. RSPAL Dr. Ramelan Surabaya surveyed patients diagnosed with invasive ductal carcinoma utilizing a total sampling technique. The patient preparations for invasive ductal carcinoma were cut into paraffin blocks, stained, and then separated into three groups. Patients with grade 1 invasive ductal carcinoma were prepared in group 1, those with grade 2 invasive ductal carcinoma in group 2, and patients with grade 3 invasive ductal carcinoma in group 3. Subsequently, TILs were counted under a microscope for each group. There were 28% TILs in the mild group, 44% in the moderate group, and 28% in the high group of patients with grade 1 invasive ductal breast cancer. Patients with grade 2 invasive ductal breast cancer were categorized as having a low number of TILs 16%, a moderate number 40% or a high number 44%. Subjects with grade 3 invasive ductal breast cancer were categorized as having a low number of TILs 44%, a moderate number 24%, or a high number 32%. The study found a highly significant (p = 0.001) correlation between the TILs variable and the grade of invasive ductal breast cancer. This correlation was shown to be unidirectional.
The effectiveness of yoga exercise with fast walking on changes in blood pressure and random blood glucose (rbp) in diabetes mellitus women at tamalanrea health center makassar
Authors: Sriwahyuni  , Haskas Yasir , Darmawan Sri , Kasim Jamila , Thalib Abdul
Published: December 2024

Aging, as a natural phenomenon, has a significant impact on health with an increased risk of chronic diseases, including diabetes mellitus (DM); this study was aimed at determining the effectiveness of yoga and brisk walking on changes in blood pressure and RBP in diabetes mellitus at the Tamalanrea Jaya Makassar Health Center.This study used a pre-experimental design with a One Group Pretest-Posttest approach to evaluate the effectiveness of Yoga gymnastics and brisk walking on changes in blood pressure and RBP scores in women with Diabetes Mellitus at Puskesmas Tamalanrea Makassar. Data collection was conducted using blood pressure measurement tools and RBP, which have been validated and calibrated to ensure the accuracy of measurement results. Statistical analysis was performed using a Paired Samples t-test to analyze changes in blood pressure and a Wilcoxon Signed-Rank Test to examine changes in RBP. Results Bivariate analysis showed significant changes in blood sugar after yoga training activities (p=0.000), with a decrease from 224.22 mg/dl to 164.77 mg/dl, while blood pressure was not significant (Systolic: p=0.301, diastole: p= 0.117). The brisk walking activity showed a significant reduction in blood sugar (p=0.000) and systolic blood pressure (p=0.001), without significance in diastolic blood pressure (p=0.422). A comparison between the two activities showed that yoga practice activity was more effective in reducing blood sugar (p=0.000), but there was no significant difference in lowering blood pressure. The Mann-Whitney test results confirmed a substantial comparison between yoga exercise and brisk walking in lowering blood sugar (p=0.000). In contrast, the difference in lowering blood pressure was not significant. Both yoga and brisk walking are effective at lowering blood sugar, with yoga being more effective, and recommend both as DM management strategies for follow-up research, preferably with larger samples and tighter control needed for a deeper understanding
Gastrointestinal quality of life index 10 (GIQLI-10) in Bahasa Indonesia: Translation and validation of a standardized questionnaire to assess patient symptoms
Authors: Arifin Fransiscus , Kuntaman Kuntaman , Suprabawati Desak G.A.
Published: December 2024

The Gastrointestinal Quality of Life Index (GIQLI-10) is a standardized measure of quality of life for gastrointestinal symptoms. Out purpose is  translating and validating the GIQLI-10 to Bahasa Indonesia for use in the Indonesian population. Cases of gastrointestinal disease is rising in Indonesia, possibly due to changes in dietary patterns and infectious diseases. Therefore, it is necessary to adequately measure the symptoms of gastrointestinal diseases quantitatively and its impact on the quality of life of the patient.  A simple and valid standardized questionnaire is necessary, which can be implemented in daily practice, requiring limited implementation time. GIQLI-10 is a tool to evaluate the quality of life of patients with gastrointestinal disorders, covering both their symptoms and overall well-being. However, as a closed-ended questionnaire, it may have limitations in capturing the full spectrum of individual patient symptoms and rely on subjective responses influenced by cultural factors. Despite these limitations, GIQLI-10 has been validated in various languages and populations, demonstrating its reliability and validity across different cultural backgrounds and diseases. The successful translation and validation of the GIQLI-10 into Bahasa Indonesia will facilitate its use in assessing the quality of life of Indonesian patients with gastrointestinal disorders, aiding diagnosis, treatment planning, and research. Our objective is to translate GIQLI-10 to Bahasa Indonesia and assess it’s reliability and validity. We used a standardized translation method recommended for medical questionnaires. The final version of the questionnaire was tested for its validity and reliability. Reliability was measured using Cronbach's alpha, which yielded a score of 0.714. Internal validity was assessed for each item using Pearson's correlations, which shows that the translated version is valid and reliable. This questionnaire can be implemented in a short duration, and applied to all patients with gastrointestinal symptoms.