bluuebunny/crossref_metadata_2025 huggingface dataset:
MPV vs. Optical Platelet Volume Measurement: Which Is a Better Indicator for Neonatal Sepsis?
Authors: Yang Hao , Bao Jiqian , Guo Siqi , He Jiajing , Ye Lei , Zhang Yingjun , Dai Qingkai , Zhang Ge
Published: December 2024

Objective
To evaluate the accuracy of mean platelet volume (MPV) testing in the neonatal population and assess the applicability of the optical platelet volume measurement method on Sysmex XN9000 in this demographic.
Method
From June 2023 to June 2024, we analyzed complete blood count (CBC) data from 1070 neonates with infections to assess MPV testing reliability using instrument alerts and histograms. Additionally, 284 neonates without infections or hematologic diseases were included to evaluate the Sysmex optical platelet volume indicator (PLT-F-Y) reliability. Finally, four cases of neonatal sepsis were examined to determine the correlation between PLT-F-Y and neonatal sepsis.
Results
In neonates with infections, 24.67% of MPV data did not accurately reflect platelet volume, and this issue was not confined to cases with low platelet counts. The PLT-F-Y indicator demonstrated superior accuracy in measuring platelet volume, with a reference range of approximately 42.6-64.2 MFI for neonates. Additionally, PLT-F-Y correlated with the progression of neonatal sepsis.
Conclusion
MPV is not a “perfect” indicator for newborns, whereas PLT-F-Y may serve as a potential better alternative.
The association between the body roundness index and the risk of rheumatoid arthritis: a cross-sectional study based on NHANES
Authors: Zheng Zhou , Wang Huaguo , Chen Xiang , Chen Ruizhou , Wu Xinyi , Liu Longcha , Fu Cheng , Hu Mingpeng
Published: December 2024

Objective:There is increasing evidence of an association between rheumatoid arthritis (RA) and obesity. However, the precise relationship between BRI, a novel indicator of visceral fat, and RA remains unclear. The objective of this study was to investigate the relationship between BRI and RA risk.
Methods: A cross-sectional study was conducted using data from the NHANES from 2011 to 2020. A logistic regression analysis was employed to investigate the correlation between the BRI and RA risk, and restricted cubic splines (RCS) and fitting curve analysis were used to capture the potential non-linear relationship. Furthermore, a piecewise two-stage logistic regression model combined with smoothing techniques was employed to explore the potential threshold effect of BRI on RA risk.
Results: A total of 6.25% (830/13,273) of the 13,273 participants aged 20 and above included in the study were diagnosed with RA. The adjusted OR values for BRI and RA in Q2 (3.666, 4.924), Q3 (4.924, 6.477), and Q4 (6.470, 20.970) were compared with those for individuals with lower BRI-Q1 (1.049, 3.666). The ORs for the remaining categories were 1.22 (95% CI: 0.91–1.64, p = 0.181), 1.64 (95% CI: 1.25–2.17, p < 0.001) and 2.04 (95% CI: 1.55–2.70, p < 0.001), respectively. The results of the trend analysis showed that the adjusted OR for the trend was 1.28 (95% CI: 1.18–1.38, P < 0.001). The results of the RCS analysis indicated a significant linear correlation between the risk of RA and increasing BRI (p-value for the overall <0.001, p-value for non-linearity = 0.627). A sensitivity analysis demonstrated that when BRI was treated as a continuous variable, the observed association remained, with an adjusted OR of 1.12 (95% confidence interval: 1.08-1.15, P < 0.001). Subgroup analysis indicated that BRI interacted with smoking status, age and marital status, with never smokers, those under 50 and those living with a partner being more susceptible to BRI.
Conclusions: A significant positive correlation was observed between the risk of RA and BRI, particularly in individuals who had never smoked, were under the age of 50, and living with a partner. It is proposed that maintaining an appropriate BRI may contribute to a reduction in the incidence of RA.
Bilateral Geiger mode avalanche in InSe Schottky photodiodes
Authors: Chen Yan , Zhao Dongyang , Hu Tao , Cao Hechun , Zhao Xuefeng , Jia Yu , Wang Xudong , Shen Hong , Yang Jing , Zhang Yuanyuan , Tang Xiaodong , Bai Wei , Wang Jianlu , Chu Junhao
Published: December 2024

Avalanche photodiodes (APDs) are crucial in emerging weak light signal detection fields. The major challenge of high-performance APDs is to achieve both an ultrahigh gain and ultralow breakdown voltage. The key to efficient carrier multiplication is searching for a high-mobility semiconductor and constructing a novel device structure with an alternative mechanism. Herein, we demonstrate the bilateral Geiger mode avalanche in two-dimensional (2D) Graphene/InSe/Cr asymmetrical Schottky junction (SJ) APDs. An ultrahigh gain of 6.3 × 107 is yielded at an extremely low breakdown voltage down to 1.4 V approaching its threshold limit of bandgap of InSe. A positive temperature coefficient of the ionization rate and an ultralow critical electric field (11.5 kV/cm) are present in the Graphene/InSe/Cr SJ APDs (GISC-SJ APDs). These support the low-bias triggering impact ionization and low-loss carrier multiplication for outstanding performance along with the unique asymmetric Schottky barrier configurations. Such device architecture enables an ultralow dark current of 100 fA, and a high sensitivity with weak light signals detection ability down to around 2900 photons at room temperature. These characteristics show the prospects of the asymmetrical InSe SJs for developing energy-efficient and high-gain APDs.
Pharmacophore-Guided Computational Modeling of Marine-Derived γ-Secretase Modulators for Amyloid-Beta Reduction in Alzheimer’s Disease
Authors: Hossain Md. Sakhawat , Amin Md. Al , Sakib Md. Saruar Alam , Akter Akhi , Das Liton Chandra , Islam Md Nurul , Rahman Md Masuder
Published: December 2024

Alzheimer’s disease is primarily caused by the accumulation of amyloid-beta (Aβ) proteins, with γ-secretase playing a key role in the formation of Aβ (1–42). This study aimed to identify novel γ-secretase modulators from marine resources that selectively lower Aβ production. Using BMS 299897 and ELN 318463 as reference drugs, we developed a Shared Feature Pharmacophore (SFP) map featuring 1 hydrogen bond donor, 3 hydrogen bond acceptors, 4 hydrophobic regions, 2 aromatic bonds, and 2 halogen bond donors. Screening a library of 47,451 marine-derived compounds through this map identified six promising hits. Synthetic γ-secretase modulators were designed using fragment-based drug design by integrating bioactive fragments from these hits with the essential 4-chlorobenzenesulfonamide ring of the reference drugs. Molecular docking and pharmacokinetic analyses highlighted three compounds (Molecule 6, Molecule 24, and Molecule 28) with stronger binding affinities than BMS 299897 and favorable blood-brain barrier permeability. Additionally, 100 ns molecular dynamics simulations demonstrated stable conformational dynamics and robust interactions for Molecule 24. While these findings are promising, further experimental validation is necessary to confirm the effectiveness and safety of these compounds as potential Alzheimer’s treatments.
Lipopolysaccharide-Binding Protein (LBP): A Prognostic Biomarker for Gastric Cancer Linked to Immune Infiltration
Authors: Lv Hao , Guo Xuyang , Zhu Xiaoman , Chao Yue , Li Dandan
Published: December 2024

Background: Gastric cancer, characterized by increasing incidence and mortality rates worldwide, presents significant challenges due to the absence of effective early detection and screening methodologies. This limitation impedes timely therapeutic interventions, highlighting the necessity for novel biomarker discovery. Among potential candidates, Lipopolysaccharide-Binding Protein (LBP), implicated in several cancer types including lung, colon, and cervical cancers, emerges as a noteworthy focus. Despite its established involvement, LBP's specific contributions and mechanisms in gastric cancer require elucidation, especially considering the disease's distinct biological and pathological characteristics.
Methods: This Study leverages data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Human Protein Atlas (HPA) to scrutinize LBP's mRNA and protein expression levels in gastric cancer, exploring associations with clinical outcomes. Analytical techniques encompassed volcano plots, protein-protein interaction networks, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and immune infiltration assessments. Furthermore, lentiviral vectors containing interference sequences targeted at LBP were employed to manipulate its expression in AGS and HGC-27 gastric cancer cell lines, facilitating analyses of gene knockdown effects on cellular behaviors indicative of malignancy progression.
Results: Our pan-cancer comparative analysis across 33 cancer types revealed a significant upregulation of LBP in gastric cancer, with diagnostic ROC curve analysis yielding an AUC of 0.765. Univariate and multivariate COX regression analyses identified high LBP expression as inversely related to patient survival. Additionally, immune infiltration and functional enrichment analyses indicated LBP's involvement in pathways crucial to cancer development, such as immune response modulation and lipid metabolism. Experimentally, LBP knockdown in gastric cancer cell lines resulted in reduced proliferation, migration, and invasion capabilities, underscoring its pivotal role in tumor dynamics.
Conclusion: LBP is intricately linked to gastric cancer's pathogenesis, influencing cell proliferation, migration, and invasion, and thereby represents a valuable prognostic and diagnostic biomarker. This Study not only highlights LBP's potential as a therapeutic target but also lays the groundwork for future investigations into its mechanistic pathways in gastric cancer.
Predictors of Secondary Revascularization after Coronary Artery Bypass Graft Surgery and Role of Dual Antiplatelet Therapy
Authors: Ch Iftikhar Ali , Nasir Khurram , Chaudhry Azhar , Wu Pei-Tzu , Siddique Muhammad , Ullah Raja , Tahirkheli Mashal , Qadar Abdul , Weitzel Hunter , MBBS Rahat Jamal , Tahirkheli Naeem
Published: December 2024

Background: Despite advancements in surgical techniques, interventional procedures, novel pharmacotherapies, and other contemporary treatments, patients’ post-CABG remain at risk for graft failure and progression of native CAD (4). Consequently, secondary revascularization is often required, with PCI being the preferred method
Methods: This is a retrospective observational study evaluating the incidence, trends, and predictors of revascularization after CABG surgery. Antiplatelet therapy and its impact on revascularization after CABG were analyzed.
Results: Of 2,476 patients followed in this post-CABG study, the analysis included 1,006 patients who received AMT and 770 patients who received DAPT for six months or more after surgery. The survival rates were 92.0% for AMT and 96.5% for the DAPT group (odds ratio (OR)=0.421, 95% confidence interval (95% CI): 0.269-0.658; p<0.001). In patients who received DAPT after CABG, a significantly higher incidence of revascularization was noted, compared to AMT (22.08% vs 6.96%; OR=3.157, 95% CI: 2.734-4.940; p<0.001). The binary regression model revealed that younger patients (HR=0.964, 95% CI: 0.95-0.97; p <0.001), diabetics (HR=1.50, 95% CI: 1.12-2.00, p=0.007), patients who had fewer internal mammary artery grafts (HR=0.54, 95% CI: 0.36-0.81, p=0.003), and patients receiving DAPT of any duration after CABG (HR=3.47, 95% CI: 2.55-4.72, p<0.001) were more likely to receive revascularization after CABG (Table 2). The model, comprising these four predictors, was able to explain 12.8% of the variance in post-CABG revascularization (Nagelkerke R² = 0.128; p < 0.001).
Conclusion: Diabetes mellitus, younger age, fewer IMA grafts, and the use of DAPT after CABG were strong predictors of the need for secondary revascularization
GBA1 mutations alter neuronal excitability and ultrastructure in Parkinson´s disease, regulating VGLUT2 and CRYAB in dopaminergic neurons
Authors: Rodríguez-Traver Eva , Suárez Luz M. , Crespo Carlos , González-Burgos Irene , Vecino Rebeca , Jurado-Coronel Juan C. , Galán María , González-González Marta , Díaz-Guerra Eva , Moratalla Rosario , Vicario Carlos
Published: December 2024

Mutations in the glucocerebrosidase 1 (GBA1) gene are major risk factors for Parkinson´s disease (PD), but their role in PD etiopathology is not fully understood. The impact of GBA1 mutations on neuronal maturation, function and degeneration was investigated in dopaminergic (DA) neurons obtained from induced pluripotent stem cells (iPS cells/iPSCs) derived from PD patients carrying the heterozygous N370S or L444P mutation in GBA1. DA neurons co-expressing TH and VGLUT2 were detected in the cultures, and their number and/or expression of VGLUT2/SLC17A6 mRNA was markedly reduced in both N370S and L444P cultures compared to controls. Electrophysiological recordings revealed a significant increase in the firing rate of N370S but not L444P neurons, whereas evoked dopamine release was stronger from neurons carrying either mutation than from the controls. Furthermore, there was a significant accumulation of α-synuclein aggregates in the cell body and dendrites of N370S neurons. Remarkably, neurons carrying either GBA1 mutation accumulated abundant Lewy body-like inclusions, multilamellar bodies, Golgi apparatus vacuolated dictyosomes and autophagosomes. Notably, a significant upregulation of the chaperone CRYAB/HSPB5/alpha-crystallin-B was found early in DA neuron differentiation and in the substantia nigra of PD patients. Therefore, our cellular model allows clear features of neurodegeneration to be detected in neurons derived from PD patients. Our findings indicate that N370S and L444P GBA1 mutations impair midbrain DA neurons expressing VGLUT2, and provoke molecular, functional and ultrastructural changes, possibly involved in PD etiopathology. They suggest that VGLUT2 and CRYAB may potentially serve as early molecular targets and/or biomarkers in GBA1-PD.
A fast convolution-based method for peridynamic models in plasticity and ductile fracture
Authors: Mousavi Farzaneh , Jafarzadeh Siavash , Bobaru Florin
Published: December 2024

We introduce the fast convolution-based method (FCBM) for a peridynamic correspondence (cPD) model to simulate finite plastic deformations and ductile fracture in 3D. The cPD model allows the direct use of classical finite plasticity constitutive ductile failure models, like the Johnson-Cook (J-C) model used here. We validate the FCBM for the cPD model against experimental results from the literature on ductile failure in Al2021-351 alloy samples of various geometries. Notably, calibration of elastic and hardening material parameters is made only using the experimental data from the simplest geometry, a smooth round bar, and only up to the necking point. We then use that calibrated model beyond necking, through full failure, and for all the different sample geometries. The performance (speedup and memory allocation) of the new method is compared versus the meshfree method normally used to discretize PD models for fracture and damage. The proposed method leads to efficient large-scale peridynamic simulations of finite plastic deformations and ductile failure that are closer to experimental measurements in terms of displacement and plastic strain at failure than previous FEM-based solutions from the literature.
Elaboration of Novel Biocomposite Hydrogel Polymers made of Alginate and Sepiolite and endowed with Enhanced Properties
Authors: BAZIZ Meriem , KAMECHE Mostefa , BENHARRATS Nassira , HU Liran , REMITA Samy
Published: December 2024

Nowadays growing attention is given to the design and development of novel interpenetrating polymer networks (IPN) from the combination of hydrogel polymers loaded with natural clay. In this work, we used the eco-friendly IPN strategy to develop novel hydrogel biocomposite beads, made of alginate (ALG), with improved clay dispersion, higher pH sensitivity, better stretchability and swellability, together with enhanced regenerability properties and biodegradability resistance. Fibrous clay, namely sodium sepiolite (NaS), was loaded into alginate simple biocomposite network (SBN) beads, via manual co-grinding mixture/encapsulation method, at different sepiolite loads. Alginate double biocomposite network (DBN) beads were also prepared at different sepiolite loads, via the diffusion of acrylamide monomer (AAM) inside alginate single biocomposite network (SBN) beads, followed by in situ free radical polymerization of AAM into poly-acrylamide (pAAM), using ammonium persulfate (APS) as polymerization initiator and N,N-methylenebisacrylamide (Bis) as covalent crosslinker agent. The as-elaborated SBN and DBN beads were then characterized by digital camera recording, XRD analysis, ATR-FTIR characterization and SEM observation. FTIR results showed that NaS and pAAM were successfully incorporated into DBN beads, whilst XRD analysis revealed the enhancement of fibrous clay dispersion, even at relatively high sepiolite loads. Besides, SEM microscopy confirmed the porous spongious nature of DBN beads. The properties of the as-elaborated SBN and DBN beads were also evaluated by test touching, swelling rate measurements, adsorption/desorption experiments and biodegradability evaluation. DBN beads properties were always found enhanced in comparison with those of SBN beads: very good stretchability, good swelling behavior and stability in water whatever the pH, either in acidic or alkaline solution, enhanced adsorption/desorption properties towards methylene blue (MB) dye, very good regenerability and delayed biodegradability. In summary, this work showed an interesting and safe IPN/biocomposite approach to develop high-performance alginate biocomposite polymers as a promising system towards their use in eco-friendly processes.
Document embeddings for long texts from Transformers and Autoencoders
Authors: Christou Lenos , Bompotas Agorakis , Makris Christos
Published: December 2024

In document categorization, the escalating volume of digital data underscores the critical need for advanced techniques in generating semantically rich document embedding, particularly for topic modelling applications. This article presents a novel methodology that leverages the capabilities of Sentence-BERT (SBERT) for sentence embedding, aiming to address the challenges associated with embedding longer texts. The process begins by decomposing documents into individual sentences that can be processed using the SBERT model which generates an embedding for each sentence. Subsequently, a clustering algorithm is employed to select representative sentence embeddings for each document. These embeddings serve as the foundation for constructing comprehensive document embeddings through an autoencoder. This research exclusively explores the autoencoder approach, discarding alternative methods for brevity and focus. The autoencoder strategy showed promising results, occasionally outperforming the base model, Doc2Vec, in specific scenarios. This highlights the method's potential effectiveness in document embedding tasks where understanding long context is important. Moreover, when the Transformer Autoencoder was fine-tuned on test data, it achieved performance comparable to that of Doc2Vec, underscoring the viability of this approach. The findings suggest considerable room for improvement in various aspects of the methodology, including the clustering process and the encoder architecture. This article underscores the potential of autoencoders in advancing the state-of-the-art in document embedding technologies, setting the stage for further refinement and exploration.
Pragmatic information of aesthetic appraisal
Authors: Graben Peter beim
Published: December 2024

A phenomenological model for aesthetic appraisal is proposed in terms of pragmatic information for a dynamic update semantics over belief states on an aesthetic appreciator. The model qualitatively correlates with aesthetic pleasure ratings in an experimental study on cadential effects in Western tonal music. Finally, related computational and neurodynamical accounts are discussed.
Robust Audio-Image Steganography using Cross-Modal Based Transformer Models
Authors: Taremwa Mark , Anaedevha Roger Nick , Trofimov Alexander Genadievich
Published: December 2024

This research investigates the use of Vision Transformers (ViT), Audio Spectrogram Transformers (AST), and Cross-Modal Transformers (CMT) in audio-image fusion tasks, aiming to improve the representation learning and interaction between auditory and visual data. The ViT model extracts visual features from image patches resized to 224x224 pixels, while the AST model converts audio signals into mel spectrograms to capture detailed auditory features. The central focus is on the robust CMT model, which integrates visual and auditory features through a cross-modal attention mechanism. Extensive experiments using a diverse audio-image dataset from Kaggle reveal significant improvements. The initial developed ViT model enhances image embedding capacity by 12%, the AST model improves audio embedding tasks by 15%, and the CMT model achieves and overall embedding capacity increased by an average of 58.7%, an image PSNR improved by an average of 57.5%, image MSE reduced by an average of 87.3% as the CMT model shows more consistent performance across all the different stegos. this enhancement in cross-modal retrieval tasks, highlighting the effectiveness of robust CMT model in learning and utilizing inter-modal relationships. The proposed robust cross-modal attention mechanism outperforms traditional ViT model and Least Significant Bits [LSB] concatenation algorithms in feature alignment accuracy. Ablation studies further validate the robustness of this approach, demonstrating the contribution of each component to overall performance. This research establishes the viability and superiority of transformer-based architectures in audio-image fusion tasks, suggesting potential advancements in cross-modal tasks like audio-visual synchronization and multimodal sentiment analysis.
Interpretable machine learning classifiers implicate GPC6 in Parkinson’s disease from single-nuclei midbrain transcriptomes
Authors: Farhan Sali , Fiorini Michael , Li Jialun , Fon Edward , Thomas Rhalena
Published: December 2024

Parkinson’s disease (PD) is a progressive and devastating neurodegenerative disease. An incomplete understanding of its genetic architecture remains a major barrier to the clinical translation of targeted therapeutics, necessitating novel approaches to uncover elusive genetic determinants. Single-cell and single-nuclear RNA sequencing (scnRNAseq) can help bridge this gap by profiling individual cells for disease-associated differential gene expression and nominating genes for targeted genomic analyses. Here, we introduce a machine learning framework to identify molecular features that characterize post-mortem brain cells from PD patients. We train classifiers to distinguish between PD and healthy cells, then decode the models to unravel the ‘reasons’ behind the classifications, revealing key genes expression signatures that characterize cells from the parkinsonian brain. Application of this framework to three publicly available snRNAseq datasets characterizing the post-mortem midbrain identified cell-type-specific gene sets that accurately classify PD cells across all datasets, demonstrating our approach's capacity to identify robust molecular markers of disease. Targeted genomic analyses of the key genes characterizing PD cells revealed a previously undescribed association between PD and rare variants in GPC6, a member of the heparan sulfate proteoglycan family, which have been implicated in the intracellular accumulation of α-synuclein preformed fibrils. We replicate this association in three separate case-control cohorts. Our method promises to enhance understanding of the genetic architecture in complex diseases like PD, representing a critical step toward targeted therapeutics. Our publicly available framework is readily applicable across diseases.
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity
Authors: Fejzo Marlena , Wang Xinran , Zöllner Julia , Gualdo Natàlia Pujol , Laisk Triin , Finer Sarah , Heel David van , Team Genes & Health Research , Brumpton Ben , Bhatta Laxmi , Hveem Kristian , Jasper Elizabeth , Edwards Digna Velez , Hellwege Jacklyn , Edwards Todd , Jarvik Gail , Luo Yuan , Khan Atlas , MacGibbon Kimber , Gao Yuan , Ge Gaoxiang , Averbukh Inna , Soon Erin , Angelo Mike , Magnus Per , Vaudel Marc , Shu Chang , Mancuso Nicholas , Team Estonian Biobank Research
Published: December 2024

While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal, fetal, and child outcomes. Herein we performed a multi-ancestry genome-wide association study (GWAS) of severe nausea and vomiting of pregnancy of 10,974 cases and 461,461 controls across European, Asian, African, and Latino ancestries. We identified ten significantly associated loci, of which six were novel (SLITRK1, SYN3, IGSF11, FSHB, TCF7L2, and CDH9), and confirmed previous genome-wide significant associations with risk genes GDF15, IGFBP7, PGR, and GFRAL. In a spatiotemporal analysis of placental development, GDF15 and TCF7L2 were expressed primarily in extra villous trophoblast, and using a weighted linear model of maternal, paternal, and fetal effects, we confirmed opposing effects for GDF15 between maternal and fetal genotype. Conversely, IGFBP7 and PGR were primarily expressed in developing maternal spiral arteries during placentation, with effects limited to the maternal genome. Risk loci were found to be under significant evolutionary selection, with the strongest effects on nausea and vomiting mid-pregnancy. Selected loci were associated with abnormal pregnancy weight gain, pregnancy duration, birth weight, head circumference, and pre-eclampsia. Potential roles for candidate genes in appetite, insulin signaling, and brain plasticity provide new pathways to explore etiological mechanisms and novel therapeutic avenues.
Relationship of Early Life Adversity to Moral Development and Psychopathology among Children and Adolescents: A Cross-Sectional Study
Authors: Khurana Priyal , Singh Ram , Galvin Matthew , Gaffney Margaret , Gupta Mayank
Published: December 2024

Introduction
Empirical evidence suggests early adverse life experiences are linked to delays in moral development. This study aims to assess the correlation between PI and delayed conscience formation in moral development.
Methods
The study included 125 semi-structured interviews with youth who experienced adverse childhood experiences and compared their conscience development with youth raised in relatively advantaged environments. Conducted in two phases, the first phase used a two-sample z-test to compare distress indicators of conscience impairment between groups. In the second phase, cases were analyzed using prototypical vignettes and conscience development quotient scores. The severity of psychopathological interference was assessed using behavioral ratings and DSM categorical diagnoses. Multiple linear regression examined the association between conscience development quotient and severity of psychopathological interference, including six covariates. A similar regression model was used to assess the association between psychopathological interference and clinical global assessment of functioning scores using the same covariates.
Results
Findings suggest severity of psychopathological interference, presence of other mental health conditions, onset of adverse life experiences to play a role in conscience development.
Discussion
The future implications suggest a humanistic approach to seek insights into moral development and present an alternative of global assessment of functioning that was discontinued because of its shortcomings, which conscience development quotient can bridge.
Nyugdíjasok rekreációja és szabadidő felhasználásának időbeli összehasonlító elemzése
Authors: Tessényi Judit
Published: December 2024

A kutatás célja a nyugdíjas korúak életmódjának és szabadidős tevékenységeinek jobb megértése, és az eredmények összesített feldolgozása. Némileg meglepő módon jelentősen javult a nyugdíjasok jólléte és életminősége -  a mért mutatók mentén, a megkérdezettek körében - az előző, 8 évvel korábban mért adatokhoz képest. A korábbi kutatások rámutattak arra, hogy az aktív szabadidős tevékenység számos előnnyel járhat, mint például az egészség javítása és a társas kapcsolatok építése. Azonban sok idős embernek hiányzik a külső vagy belső ösztönzés a fizikai aktivitás, hobbi vagy társas kapcsolatok fenntartásához, ami befolyásolhatja jólétüket és élettel való elégedettségüket. A korábbi kutatásunk során hat fő témakört azonosítottunk, amelyek kulcsfontosságúak az idősek szabadidejének megértéséhez, és ezen alapulva 2024-ben ismétlő kutatást végeztünk a nyugdíjasok tevékenységeinek felmérésére. Ennek során fontosnak bizonyult az aktívitás, életkörülmények, egészség, motiváció, napi teendők és egyéb tényezők vizsgálata. A mostani válaszadók rendszeresen végeznek testmozgást, aktívan részt vesznek szellemi tevékenységekben, és egyre többen használnak technológiai eszközöket a társas kapcsolatok és a szabadidős tevékenységek szervezése céljából. A változásokat számszerűsítettük, amely az idős emberek preferenciáit mutatja a különböző tevékenységek terén az eltelt időszak alatt.
Índice de homogeneização da paisagem: estudo de caso TI Piripkura e Setores Censitários do entorno
Authors: Acquolini Gabriela Tirello , Freitas Marcos Wellausen Dias de
Published: December 2024

A Amazônia representa o maior bioma do Brasil, assumindo uma posição proeminente no contexto global. O incremento das atividades agropecuárias e a extração dos recursos naturais de forma desenfreada põem em risco a manutenção desse ambiente natural, introduzindo novos hábitos culturais centrados na vida urbana. Consolida-se, assim, a homogeneização da paisagem, que pode ser observada a partir das consequências da atividade humana. Nesse contexto, as Terras Indígenas atuam como “escudos”, protegendo seus povos, a biodiversidade, os estoques de carbono e os serviços ecossistêmicos. As Terras Indígenas de Povos Isolados referem-se aos territórios de indígenas que não possuem contato direto com a sociedade em geral e, consequentemente, seus territórios sofrem maior pressão para invasão e exploração de recursos naturais. Essa pesquisa propõe um Índice de Homogeneização da Paisagem (IHP) voltado para espaços de indígenas isolados, neste caso a Terra Indígena Piripkura, e os Setores Censitários em seu interior e em seu entorno, a fim de fornecer subsídios para a tomada de decisões e planejamento territorial. De maneira geral, a aplicação desse índice demonstrou maior IHP em áreas próximas a rodovias, sedes urbanas e com maior densidade populacional, enquanto áreas de Unidade de Conservação e Terras Indígenas apresentaram um índice menor.
Incidência do staphylococcus aureus na produção do queijo de coalho artesanal e qualidade de novas formulações
Authors:   , Medeiros Jovilma Maria Soares de
Published: December 2024

Diante da necessidade de um alimento com qualidade sanitária e nutricional

objetivou-se caracterizar Staphylococcus aureus presente na produção de queijo de

coalho artesanal, bem como a utilização de produtos naturais (ervas e inulina) na

elaboração desse produto. Para tanto foram isoladas colônias de S. aureus presentes no leite, equipamentos e utensílios utilizados na fabricação, etapas do preparo e o produto final de dois estabelecimentos produtores, totalizando 52 amostras. Foram realizadas a identificação fenotípica das colônias, a pesquisa de genes codificadores de enterotoxinas, de resistência a antibióticos e a tipagem por agr typing, além do teste de sensibilidade a antibióticos. Foram elaborados dois queijos de coalho artesanais. Em uma produção utilizou-se a substituição de cloreto de sódio por ervas nas proporções de 30%, 22,2% e 12,5%. Também foi utilizado leite semidesnatado e integral com adição de 8% de inulina na produção do segundo produto. Nas amostras dos dois queijos fabricados foram analisados o crescimento microbiano, a composição química e parâmetros físicos durante 10 dias de armazenamento refrigerado e realizada análise sensorial. No processo produtivo do queijo de coalho observou-se elevada contaminação (50%) por S. aureus, assim como presença de gene produtor de enterotoxina sea (19%) e gene mecA (45,7%). Os genes dos grupos agr estiveram presentes no processo de produção do queijo com maior prevalência do agr III (12,7%). Quanto a resistência a antibióticos observou-se resistência múltipla a penicilina, oxacilina, eritromicina e clindamicina em 79% dos isolados. Nas formulações com ervas foi possível reduzir as contagens de estafilococos coagulase positiva (5,64 log UFC/g) até o 5º dia de armazenamento, assim como o teor de sódio e melhorar a aceitação do queijo com a adição de 12,5% de ervas. Em relação a inulina, esta não interferiu no crescimento microbiano e manteve a aceitação sensorial

equivalente ao queijo de coalho sem inulina. Nos estabelecimentos onde a produção de queijo de coalho foi analisada encontraram-se cepas de S. aureus com potencial

enterotoxigênico demonstrando a necessidade de uma fabricação com melhores

condições de higiene. Além disso, a adição de ervas pode ser uma alternativa para

melhorar a qualidade microbiológica, que aliada a utilização da inulina melhoram a

qualidade nutricional do queijo de coalho.
Gestão de resíduos sólidos em instituição de ensino superior: Potencial de conservação de energia elétrica a partir da reciclagem
Authors: França Matheus Henrique Medeiros de , Melo Lais Aparecida Nascimento de , Leonês Anderson Felipe Costa , Varella Fabiana Karla de Oliveira Martins , Lunardi Diana Gonçalves
Published: December 2024

A gestão eficiente de resíduos em instituições de ensino superior desempenha um papel relevante na conservação de energia elétrica. Sendo assim, este estudo analisa o potencial de conservação de energia por meio da reciclagem na Universidade Federal do Rural do Semi-Árido (UFERSA), desde as práticas de gestão de resíduos da Instituição, assim como o processo de reciclagem, destacando os protocolos e leis ambientais, e o potencial de conservação de energia de diferentes materiais, incluindo papelão, vidro e outros resíduos comuns na Universidade. No desenvolvimento da metodologia foi utilizado o modelo SARIMAX sendo possível projetar a geração futura de resíduos na Instituição e avaliar a tendência do potencial de conservação. A partir de análises desenvolvidas do cenário atual, os resultados revelaram que a conservação de energia por meio da reciclagem na UFERSA tem o potencial promissor. Os resultados também ressaltam a importância da implementação de práticas sustentáveis de gestão de resíduos em instituições de ensino superior, não apenas para reduzir o impacto ambiental negativo, mas também para contribuir significativamente para a conservação de energia elétrica em nível local e global.
Mobilidade acadêmica na UFERSA
Authors: Menezes Leia Mara de
Published: December 2024

A mobilidade estudantil é o processo que possibilita ao discente matriculado em uma instituição de ensino superior adquirir vínculo temporário com uma instituição de ensino receptora para cursar componentes curriculares. Ao final do período de mobilidade acadêmica o discente retorna à instituição ou campus de origem, podendo aproveitar os componentes curriculares cursados durante o período de afastamento. Ao contrário do que acontece na transferência entre instituições de ensino, na mobilidade acadêmica, o estudante não interrompe o vínculo com a instituição de ensino ou campus de ingresso.
Pros and Cons of Cardiovascular Herbal Therapy: Molecular Docking, ADMET, Physiological and Pharmacological Significance
Authors: Kadi Mounime , Berraouaan Ali , Ziyyat Abderrahim , Mekhfi Hassane , Bnouham Mohamed , Legssyer Abdelkhaleq
Published: December 2024

Introduction:

For a long period, traditional medicine has held a crucial role in maintaining
cardiovascular homeostasis. However, very few scientific studies have investigated and reported
information on the mechanism by which these plants act through their active ingredients. Presently,
there is consideration for utilizing computer-assisted methods to incorporate predictive and dependable
data in addition to experimental findings.

Objective:

The objective of this review article was to furnish information on medicinal plant extracts
that have undergone experimental testing to assess their cardioprotective properties

Methods:

Thus, eleven phytomolecules have been chosen based on their bioactivity scores and their
belonging to medicinal plants frequently used in traditional medicine. Molecular docking analyses
were carried out using Autodock Vina v1.5.7, and were performed to research the molecular pathway
attributed to the effects of phytoconstituents extracted from medicinal plants known for their therapeutic
effects against cardiovascular alterations. Computer ADME/toxicity studies were also performed
to estimate the physiological and pharmacological signification of each phytomolecule.

Results:

The results showed that selected phytomolecules exert considerable therapeutic potential on
different cardiovascular levels through activation, inhibition, and modulation of cellular factor's expressions,
all leading to cardiac muscle protection against stressful attacks. ADMET analysis showed
that all phytomolecules selected responded to drug-likeness according to Lipinski's rule of five and
the possibility of developing medicines, taking into account the dose used for each phytoconstituent.

Conclusion:

Our study demonstrated that various medicinal plants possess significant therapeutic
potential at multiple cardiovascular levels through a series of vital processes, including activation,
inhibition, and modulation of diverse cellular component expression.
Exploration of the Potential Mechanism of Sedum sarmentosu Bunge in the
Treatment of Hepatic Fibrosis Based on Network Pharmacology,
Molecular Docking, and Molecular Dynamics Simulation
Authors: He Wenfei , Tang Yao , Chen Jialin , Chai Yu , Xiong Lingyue , Zhangwei Wanqi
Published: December 2024

Background:

Sedum sarmentosu Bunge (SSB), a perennial herb, exhibits notable therapeutic
effects on hepatic fibrosis (HF). However, the mechanism of treatment has not been fully determined.

Objective:

The objective of this study is to explore the active components in SSB and investigate its
molecular mechanism of action in the treatment of HF based on network pharmacology, molecular
docking, and molecular dynamics simulation (MD).

Methods:

Databases such as TCMSP, Gene Cards, OMIM, and DAVID, as well as Cytoscape, AutoDock
Vina, and Gromacs software, were used for analysis.

Results:

A total of 5 active components and 86 HF-related targets were screened for SSB, among
which the most prominent components are luteolin and quercetin. The key targets for HF are MMP2,
MMP3, MMP9, ABCG2, etc. GO enrichment analysis showed that SSB was closely associated with
apoptosis, inflammatory response and cell migration processes. KEGG enrichment analysis showed
that the major enrichment pathways for liver fibrosis include EGFR tyrosine kinase inhibitor resistance,
PI3K-Akt signaling pathway, and cancer-related pathways. Molecular docking and MD
showed that luteolin and quercetin have good affinity and stable binding to MMP2, MMP3, and
MMP9.

Conclusion:

SSB exerts therapeutic effects on HF through multiple components, targets, and pathways,
thereby providing a theoretical foundation for the development of its active compounds and
mechanisms of action.
Targeting Breast Cancer: Novel Dihydropyrimidinones As Potent Eg5 Inhibitors
Authors: Nikam Dhirajkumar , Jain Anurekha , Vetale Shraddha , Bhange Ashwini , Jadhav Shweta
Published: December 2024

Introduction:

Breast cancer remains a formidable health concern for women, necessitating
the development of potent anticancer agents with improved safety profiles. Dihydropyrimidinones
(DHPM), pyrazole, and benzofuran scaffolds have emerged as promising targets due to their
diverse pharmacological profiles. In this study, we employed a scaffold hopping approach to design
a novel DHPM-Pyrazole-Benzofuran core. A series of compounds (3a–3j) were synthesized using
the Biginelli protocol, and their characterization was performed using various techniques such as
FTIR, 1H NMR, and Mass spectroscopy.

Methods:

Molecular docking studies against kinesin spindle protein Eg5 (1Q0B) performed to find
superior binding interactions compared to the prototype Eg5 inhibitor Monastrol. Anti breast cancer
potential of these compounds was screened against the breast adrenocarcinoma MCF-7 cell line
using an SRB assay.

Results:

Compound 3j showed good growth inhibitory activity (GI50=24.08μM) compared to Monastrol
(GI50=32μM) employed as a positive control. Moreover, Compound 3j exhibited strong
interactions with amino acids GLU-116 and ARG-119 with Eg5 protein 1Q0B.

Conclusion:

Compound 3j fits well at the allosteric site of Eg5 protein 1QOB. Compound 3j
emerged as the most cytotoxic, displaying significant and impressive growth inhibitory activity
(GI50=24.08μM).
The Structural Design and Analysis of the Multi Nozzle Relay Air-Jet Inserting System by Profile Reed Guiding for 3D Weaving Machine
Authors: Wang Yixuan
Published: December 2024

Introduction:

Based on the literature, this article designs a parameterized simulation
model of a multi-layer jet weft insertion system by profiles reed guidance for a 3D loom on the
PTC Creo9.0 platform, including the main supersonic nozzle, supersonic auxiliary nozzle (relay
nozzle), and multi-slot profiles reed components.

Method:

Based on the existing basic theory, experimental results, and empirical data of turbulent
jet, the parameters of the multi-layer jet weft insertion system, as well as the structural parameters
and the relative positions of the main, auxiliary nozzle and profile reed components, such as the
center distance of each layer's main nozzle, auxiliary nozzle spacing, auxiliary nozzle installation
angle, spray direction angle, and spray angle, have been determined preliminarily.

Result:

Further, the basic flow field parameters, such as the supply pressure of the main and auxiliary
nozzles and the shape of multi-layer profile reeds, have been determined optimally on the Virtual
Prototype Collaborative Simulation Platform (PTC Creo9.0/ANSYS Workbench/Fluent
2024R1), and the rationality of the structural design also been verified; on the premise of ensuring
that the airflow velocity of each layer's profiles groove meets the requirements of weft insertion,
the design and simulation calculation is repeatedly modified, and the optimal structural design parameters
of the multi-layer weft insertion system and nozzle is finally determined.

Conclusion:

To explore the feasibility of multi-layer jet weft insertion, the design of threedimensional
multi-layer jet weft insertion looms has laid a theoretical foundation, laying a good
foundation for the emergence and industrial manufacturing of three-dimensional multi-layer jet
weft insertion looms, and providing an important reference for the innovative design of threedimensional
multi-layer water jet weft insertion looms.
Investigating the Influence of 0.75% Ethanol Extract Gel from “Kaempferia galanga L Rhizoma” on Mild and Moderate Acne Vulgaris Among High School Students
Authors: Bahar Yenni , Sentono Harijono Kario , Doewes Muchsin , Soetrisno
Published: December 2024

Background:

Acne vulgaris is a prevalent dermatological condition characterized by
the inflammation of sebaceous follicles. This inflammation results in various clinical manifestations,
including open and closed comedones, papules, pustules, nodules, and cysts, which predominantly
appear on the face. The impact of acne vulgaris extends beyond physical symptoms, often
affecting psychological well-being and quality of life, particularly among adolescents. Given this
condition's widespread prevalence and significant implications, there is a pressing need for effective
and accessible treatments.

Objective:

This study aimed to evaluate the impact of Kencur Rhizome Ethanol Extract Gel
(Kaempferia galanga L. Rhizoma / KGR) on mild and moderate acne vulgaris lesions among high
school students.

Method:

Twenty-four high school students were divided into three groups: Group 1 received
0.75% Kaempferia galanga rhizome ethanol extract gel, Group 2 received a combination gel of
0.75% Kaempferia galanga ethanol extract, and 75% benzoyl peroxide with 1% clindamycin gel,
and Group 3 received 1% clindamycin gel. The number of subjects in each group was determined
using the G Power application. The distribution of gels was randomly assigned using the “Randomly
Assign Subjects to Treatment Group” application. Before treatment, blood samples were
taken to measure IL-8 levels. After three weeks of treatment, bilateral facial photographs were taken:
one with the right side tilted at 45 degrees and the other with the left side tilted at 45 degrees.
Blood samples were collected again for IL-8 measurement, and high-resolution photographs of
both sides of the face were taken to analyze acne lesions using the ImageJ application.

Result:

A combination of 0.75% KGR ethanol extract gel and 1% clindamycin gel significantly reduced
the severity of AV lesions by affecting IL8 expression (p=0.042) in reducing the severity of
mild and moderate AV lesions. For AV lesions using the ImageJ application, the administration of
group 2 gel (a combination of 0.75% KGR ethanol extract gel and 1% clindamycin gel) has a significant
effect on reducing the severity of mild and moderate degrees of whitehead or blackhead
(p = 0.030) and nodules (p = 0.035) in acne vulgaris.

Conclusion:

A combination of 0.75% kencur rhizome ethanol extract gel and 1% clindamycin gel
effectively alleviate acne vulgaris symptoms while also reducing inflammation of acne vulgaris lesions.
The Impact of the Coronavirus Pandemic on Telemedicine Evolution in Obstetrical Care During COVID-19
Authors: Nori Wassan , Fadhil Amenah , Jaafar Zainab Abdul Ameer
Published: December 2024

The COVID-19 pandemic has imposed drastic challenges to the health system and resulted
in drastic measures to reduce the high morbidity and mortality rates observed among affected
individuals. Pregnant women were faced with an unexpected suspension of anti-natal care with the
recommendation of indoor confinement. Telemedicine (Tm), defined as the delivery of healthcare
via communication, stood up as a valuable tool to address those needs with its convenience of remote
monitoring and ease of use. This review aimed to verify the transition of Tm in obstetrical care, define
factors and barriers associated with its acceptance, its performance, and how it evolved during
the COVID-19 era to guide its role in modern obstetrics. Four electronic repositories were searched:
PubMed, Scopus, WOS, and Google Scholar using the keywords (pregnant, telemedicine, COVID-
19, feto-maternal health, outcome, satisfaction, and health care); eligible studies were included in the
analysis. Despite the challenges and difficulties faced by Tm during its early implementation in the
pandemic, its effectiveness was demonstrated. Looking back to the lessons learned from the pandemic,
Tm stood out as a reliable, safe, cost-effective tool for delivering anti-natal care during lockdown.
Its role in alleviating anxiety and stress associated with the pandemic was notable. There are still
gaps in our knowledge that need to be researched further, practically, the long-term outcome of Tm
follow-up for both the mothers and their babies, and from a lower income countries' perspective as
Tm services faced digital literacy in those areas. It has been anticipated that Tm will play a crucial
role in modern obstetrics, as an integral part of the health service or as a complete part. Moreover, by
adopting the 2 models, pregnant women will have the leverage of to aim for better delivery and outcomes
in the presented health care.