bluuebunny/crossref_metadata_2025 huggingface dataset:
Consolidative radiotherapy for residual fluorodeoxyglucose activity on day +30 post CAR T-cell therapy in non-Hodgkin lymphoma
Authors: Saifi Omran , Breen William G , Lester Scott C , Rule William G , Stish Bradley J , Rosenthal Allison , Munoz Javier , Lin Yi , Bansal Radhika , Hathcock Matthew A , Johnston Patrick B , Ansell Stephen M , Paludo Jonas , Khurana Arushi , Villasboas Jose C , Wang Yucai , Iqbal Madiha , Moustafa Muhamad Alhaj , Murthy Hemant S , Kharfan-Dabaja Mohamed A. , Peterson Jennifer L , Hoppe Bradford S
Published: June 2023

Majority of non-Hodgkin lymphoma (NHL) patients who achieve partial response (PR) or stable disease (SD) to CAR T-cell therapy (CAR T) on day +30 progress and only 30% achieve spontaneous complete response (CR). This study is the first to evaluate the role of consolidative radiotherapy (cRT) for residual fluorodeoxyglucose (FDG) activity on day +30 post- CAR T in NHL. We retrospectively reviewed 61 patients with NHL who received CAR T and achieved PR or SD on day +30. Progression-free survival (PFS), overall survival (OS), and local relapse-free survival (LRFS) were assessed from CAR T infusion. cRT was defined as comprehensive - treated all FDG-avid sites - or focal. Following day +30 positron emission tomography scan, 45 patients were observed and 16 received cRT. Fifteen (33%) observed patients achieved spontaneous CR, and 27 (60%) progressed with all relapses involving initial sites of residual FDG activity. Ten (63%) cRT patients achieved CR, and four (25%) progressed with no relapses in the irradiated sites. The 2-year LRFS was 100% in the cRT sites and 31% in the observed sites (P<0.001). The 2-year PFS was 73% and 37% (P=0.025) and the 2-year OS was 78% and 43% (P=0.12) in the cRT and observation groups, respectively. Patients receiving comprehensive cRT (n=13) had superior 2- year PFS (83% vs. 37%; P=0.008) and 2-year OS (86% vs. 43%; P=0.047) compared to observed or focal cRT patients (n=48). NHL patients with residual FDG activity following CAR T are at high risk of local progression. cRT for residual FDG activity on day +30 post-CAR T appears to alter the pattern of relapse and improve LRFS and PFS.
Sisäisen yrittäjyyden merkitys työelämässä
Authors: Hytönen Kaisa , Ilonen Sanna
Published: June 2023

Tutkimuksessa tarkastellaan yrittäjyyskasvatusta opiskelijoiden näkökulmasta analysoimalla opiskelijoiden näkemyksiä oman sisäisen yrittäjyyden merkityksestä työelämässä ja sen reflektiopinnoista. Tutkimuskysymykset ovat, 1) millaisia merkityksiä opiskelijat näkevät omalla sisäisellä yrittäjyydellään työelämässä olevan ja 2) minkälaisia reflektiopintoja he käyttävät pohtiessaan sisäistä yrittäjyyttään. Tutkimus toteutettiin sisäisen yrittäjyyden aineopintotasoisella kurssilla. Aineisto muodostui 74 opiskelijan oppimispäiväkirjoista. Opiskelijat pohtivat sisäistä yrittäjyyttä osana omaa toimintaansa 21 oppimispäiväkirjassa, joihin aineisto rajattiin temaattista analyysiä varten. Tulosten mukaan sisäiseen yrittäjyyden merkitykset työelämässä kytkeytyivät merkityksiin yksilölle itselleen ja yksilöä laajempiin merkityksiin. Sisäisen yrittäjyyden nähtiin vaikuttavan pääasiassa myönteisesti omiin uramahdollisuuksiin ja ammatillisen kehittymisen mahdollisuuksiin. Yksilöä laajemmat merkitykset koskivat työnantajaorganisaatioiden suoriutumiskyvyn parantamista ja muiden työntekijöiden työssä suoriutumisen ja hyvinvoinnin tukemista. Oppimisen reflektiopinnat liittyivät kurssilla käytettyihin oppimisaktiviteetteihin, opiskelijoiden aiempiin kokemuksiin työelämästä ja harrastuksista sekä roolimalleilta oppimiseen. Yrittäjyyskasvatuksessa opiskelijoiden näkökulmat ja toiveet tulee ottaa yhä enemmän huomioon, jotta voidaan tukea heidän motivaatiotaan yrittäjyystaitoihin ja taitojen nykyistä tehokkaampaa siirtymistä työelämään.
Tieteen vapaus, minne olet matkalla?
Authors: Koskiaho Briitta
Published: June 2023

Markkinatalouden tunkeutuminen yliopistoihin Euroopan unionin yliopistopolitiikan tuella uhkaa tieteen ja tutkimuksen vapautta Saksassa.
Moraalisen uran ja institutionaalisen minän rakentuminen yliopisto-opintojen alkuvaiheessa
Authors: Koivisto Hanna , Komulainen Katri , Räty Hannu
Published: June 2023

Tutkimuksessa selvitettiin ryhmänäkökulmasta toisen vuoden opiskelijoiden kiinnittymistä yliopistoon ja sen yhteisöihin osana toimintatapaa, jolla instituutio kytkee jäsenensä arvoihinsa, normeihinsa ja toimintaansa. Tarkastelussa sovellettiin Erving Goffmanin moraalisen uran, vaiheiden ja asemien sekä institutionaalisen minän käsitteitä. Haastatteluaineiston pohjalta pääteltiin, että uusi opiskelija kohtaa yliopistossa erilaisten asemien seuraannon. Hänen on neuvoteltava moraalista uraansa suhteessa kohtaamiinsa asemiin ja niihin liittyviin hyveisiin. Näissä neuvotteluissa hänelle muodostuu sisäistetty institutionaalinen minuus. Analyysien perusteella hahmoteltiin prototyyppisen moraalisen uran malli. Tuloksia tarkasteltiin muun muassa opintojen alkuvaiheen ohjauksen kehittämisen kannalta, ja pohdittiin moraalisen uran mallin suhdetta nykyisiin ohjauksen ihanteisiin. Lisäksi pohdittiin havainnoissa esille noussutta ”sosiaalisuuden vaatimuksen” merkitystä.
”Sithän mul on mahollisuus pätevänä hakea mihinkä tahansa”
Authors: Lahtomaa Mervi
Published: June 2023

Työelämän osaamisvaatimusten muuttuessa yksilöt joutuvat neuvottelemaan suhdettaan työelämään uudella tavalla. Koulutettavuus ja työllistettävyys ovat osa nykyisiin, kilpailullisiin työmarkkinoihin sisältyvää diskurssia ja siten osa yksilöiden käsityksiä omista koulutus- ja työuristaan. Avoin yliopistokoulutus kuuluu yliopistojen jatkuvan oppimisen tehtävään, jolla vastataan työelämän muuttuviin osaamisvaatimuksiin. Avoimen väylä puolestaan on avoimiin yliopisto-opintoihin perustuva opiskelijavalintatapa. Tarkastelen tässä artikkelissa, 1) millaisia merkityksiä avoin yliopisto ja avoimen väylä saavat avoimen väylän kautta valittujen aikuisopiskelijoiden koulutus- ja työurilla ja 2) miten avoimen väylän kautta valitut aikuisopiskelijat neuvottelevat koulutettavuudestaan ja työllistettävyydestään opintojensa edetessä. Aineistona ovat opiskelijahaastattelut (N = 10). Narratiivisen analyysin tulosten mukaan avoin yliopisto ja avoimen väylä merkitsivät tärkeitä käännekohtia koulutus- ja työurilla. Avoimessa yliopistossa opiskellessaan haastatellut neuvottelivat suhdettaan yliopistokoulutukseen uudella tavalla. Opiskelun myötä opiskelijan luottamus itseensä opiskelijana lisääntyi, ja hän päätyi hakemaan avoimen väylällä tutkinto-opiskelijaksi. Tutkinnolta opiskelijat odottavat lisäarvoa koulutus- ja työurilleen ja siten vahvistusta työllistettävyydelle sekä vaikutus- ja valinnanmahdollisuuksiaan työelämässä.
Developing Teaching Material of Research Methodology and Learning with 4D Model in Facilitating Learning During the Covid-19 Pandemic to Improve Critical Thinking Skill
Authors: HL Nur Ihsan , Nasruddin Nasruddin , Sejati Andri Estining , Sugiarto Agus
Published: June 2023

This research and development aimed to produce teaching materials for research and teaching methodology courses using the 4D model. Teaching materials were arranged based on a 4-D procedure: Define, Design, Develop and Disseminate. The validated teaching materials were tested through small groups of 30 students and large groups of 90 students. It collected data using observation, interviews, documentation, and questionnaires. The data were analyzed qualitatively by data reduction, data presentation, and drawing conclusions and verification. The quantitative analysis was done by processing data from expert reviews and responses from lecturers and students using percentages. The development results were teaching materials validated by four expert validators: content-focused material, curriculum-focused material, learning design, and language. The research and development resulted in a defined stage obtained material elaboration from the point of view of the research methodology of language, mathematics, and geography. The design stage was based on the design validator's suggestion regarding an attractive appearance on the cover, chapter titles, and the format of the content of the Deepublish textbook. In the development stage, the validation results obtained an average of 76.37% with good qualifications, and the average test decision was feasible with revisions in certain parts. The test results of small group students obtained 75.19% or good qualifications. The results of the large group trial got 76.83% or good qualifications. The research concludes that teaching materials have been compiled based on 4D steps. Based on the findings, the implications of this study show that the teaching materials resulting from the development can be used as material for consideration for teachers in delivering related material under the conditions during the Covid-19 pandemic.
Development and Validation of Digital-Based Preliminary Reading Media Instruments
Authors: Kasmawati Kasmawati , Zibar Chairan , Sisi La , Juwariyah Arna , Sasmin Sasmin
Published: June 2023

This study aims to develop digital-based learning media instruments for first graders on beginner reading materials. This method of research used research and development that uses the ASSURE model. The instrument used questionnaire and validation sheet. Data analysis techniques are performed by calculating the value of the validity test results. The results showed that; 1) A digital-based learning media in the form of audio-visual has been developed using the kinemaster application for beginning reading material for grade I elementary schools which uses 3 stages of the model, namely: Analyze Learning; State Standards and Objectives; Select Strategic Technology, Media and Materials; 2) The results of the validity test on digital-based beginning reading learning media products that have been developed, as a whole are assessed by the material validator and media design. The results of the score by material experts are 89% in the "Very Valid" category, for media design experts it is obtained with 94% in the "Very Valid" category. Thus, it can be concluded that digital-based early reading learning media in Indonesian lessons for grade I elementary schools is very valid to be used as one of the media in Indonesian subjects.
Development of E-Module Using ROPES Strategy Assisted with Sigil Software to Improve Students' Critical Thinking Skills
Authors: Sugiarto Agus , Sartika Rody Putra , HL Nur Ihsan , Syarifuddin Syarifuddin
Published: June 2023

This study aims to develop an E-module with the ROPES (Review, Overview, Presentation, Exercise, summary) strategy assisted by Sigil software on elasticity and Hooke's Law to improve the critical thinking skills of class XI high school students that are valid, practical and effective. This method of research and development with the ADDIE model. The research instrument consisted of pretest-posttest questions, validation sheets, learning implementation sheets, teacher response questionnaires, and student responses. Data analysis techniques were analyzed descriptively and inferentially. The results of the study were known: 1) the validation results by three educational expert validators on the E-module with the ROPES strategy assisted by Sigil software are declared valid in terms of constructs and content with an average score of 0.85 in the very valid category so that it can be applied in learning activities, 2) the practicality of the E-module with the ROPES strategy assisted by Sigil software was measured by learning implementation sheets and questionnaires for teacher and student responses. The implementation sheet showed the average score for the limited trial class of 3.5 with the good category and the broad trial class of 3.65 with the very good category. The student response questionnaire showed the mean score for the limited trial was obtained at 83.5%, which was included in the very good category, and the broad trial and 87%, which was included in the very good category, and the teacher response questionnaire showed the average score for the limited trial. Furthermore, the broad test obtained an average result of 83% with the category very good, so the e-module was practical for learning at school. 3) the effectiveness of the E-module with the ROPES strategy assisted by Sigil software in terms of pretest-posttest questions obtained the criteria for the limited test N-Gain value of 0.68 with the Medium category and the broad test N-Gain 0.71 with the High category, supported by independent test results -samples-test which shows that there is a significant difference in learning achievement before and after using the E-module. It is concluded that the E-module with the ROPES strategy assisted by Sigil software effectively improves students' critical thinking skills in learning.
Safety monitoring of COVID-19 vaccines: February 26, 2021, To June 4, 2022, Republic of Korea
Authors: Lee Yeon-Kyeng , Kwon Yunhyung , Heo Yesul , Kim Eun Kyoung , Kim Seung Yun , Cho Hoon , Kim Seontae , Ko Mijeong , Lim Dosang , Seo Soon-Young , Cho Enhi
Published: June 2023

As of June 2022, 5 coronavirus disease 2019 (COVID-19) vaccine brands have been used in Korea’s national immunization program. The Korea Disease Control and Prevention Agency has enhanced vaccine safety monitoring through a passive web-based reporting system and active text message-based monitoring. In this study, an enhanced safety monitoring system for COVID-19 vaccines is described and the frequencies and types of adverse events (AEs) associated with the 5 COVID-19 vaccine brands were analyzed. AE reports from the web-based COVID-19 Vaccination Management System and text message-based reports from recipients were analyzed. AEs were classified as nonserious or serious (e.g., death or anaphylaxis). The AE reporting rates were calculated based on the number of COVID-19 vaccine doses administered. A total of 125,107,883 doses were administered in Korea from February 26, 2021, to June 4, 2022. Among them, 471,068 AEs were reported, of which 96.1% were nonserious and 3.9% were serious. Among the 72,609 participants in the text message-based AE monitoring process, a higher AE rate of local and systemic reactions was reported for the 3rd versus 1st doses. A total of 874 cases of anaphylaxis (7.0 per 1,000,000 doses), 4 cases of thrombocytopenia syndrome (TTS), 511 cases of myocarditis (4.1 per 1,000,000 doses), and 210 cases of pericarditis (1.7 per 1,000,000 doses) were confirmed. Six fatalities were causally associated with COVID-19 vaccination (1 of TTS and 5 of myocarditis). Young adult age and female sex were related with a higher AE rate for COVID-19 vaccines. Most reported AEs were nonserious and of mild intensity.
SOSIALISASI TRANSAKSI SYARIAH DAN KOPERASI SYARIAH
Authors: Rofi Siti Fatimah , Putra Purnama , Tirtajaya Mas Deden
Published: June 2023

One of the objectives of the establishment of Islamic financial institutions is to introduce sharia principles in the economic world. Officially, the Indonesian government has supported the existence of Islamic financial institutions in Indonesia by issuing a law as its official form. Sharia Financial Services Cooperative is a microfinance institution that provides sharia financial transaction services. Transactions in Sharia Cooperatives are based on Islamic jurisprudence so they are not widely known by people in general. Therefore, this Community Service aims to introduce the types of transactions that exist in Sharia Cooperatives so that people can choose the type of contract that suits their financial transaction needs. The method used in this Community Service is in the form of counseling or outreach to the Kaliabang village community with the results of the socialization of sharia transactions and sharia cooperatives showing an increase in the knowledge and understanding of citizens about contracts in Islamic sharia transactions and any sharia cooperative products based on these contracts.
PELATIHAN TEKNIK SIMAK ULANG UCAP DALAM MEMBACA RAWI MAULID NABI DI DESA SINDANGSARI
Authors: Saputra Sendi , Irham Irham , Rabianur Rabianur , Mulyadi Acep
Published: June 2023

The reading of rawi's birthday of the prophet has become a religious tradition known by the people of Sindangsari village. Usually the recital of the Prophet's birthday is held in a series of activities to welcome the birth of children, baby haircuts, aqiqah, weddings, circumcisions and celebrations of Islamic holidays. In fact, many religious educators in Sindangsari Village, especially in RT 02 RW 05 Kampung Pulo Landak, have not been able to train the community and youth in reading the Prophet's Birthday. Under these conditions, the researcher will train with “simak ulang ucap” technique. The purpose of the training in “simak ulang ucap” technique is to speed up and position the community in reading the rawi of the Prophet's birthday. Also because the rawi maulid book is a book that uses Arabic, the technique of “simak ulang ucap” is part of the method so that there are no mistakes in reading it. The training activity of “simak ulang ucap” technique in reading narrators of the Prophet's birthday was held in several meetings until the quality of reading ability was as expected by the researcher.
EDUKASI THOHAROH DALAM BUKU CATATAN DAILY HAID
Authors: Nazriyah Nazriyah , Asiah Siti , Suprihatin Suprihatin , Gunawan Hasibuan Akmal Rizki
Published: June 2023

The lack of knowledge about the boundaries of blood and purity is acknowledged to occur in every village that has minimal knowledge of fiqh. Knowing the foundation in the law of women's fiqh can be one of the changes in how to pay attention to menstruation with worship which is the purpose of human life created. There are many hidden intentions in participating in specific learning that is carried out with taklim majlis or health seminars. Potentially in the community, there are majlis taklim women or Balligh youth who are gathered at TPA Darur Rahmah. This religious learning uses the lecture method with 1 community leader reading a book "Addardir Isra' Wal Mi'raj" and the enthusiasm for gathering to recite the Koran is very high. Sindangsari Village, which coincides in Kampung Putat Rt 003 Rw 002, has a fairly busy recitation schedule for both children and housewives. With this potential, the program to introduce the matter of thoharoh and the chapter on menstruation can be delivered specifically using the book "Daily Haid notes".
Morpho-Anatomical Features of Artemisia szowitziana (Besser) Grossh., 1934
Authors: Sadigova N.
Published: June 2023

The performed anatomical studies were conducted in accordance with the generally accepted methodology. The research materials (leaf, stem, root) were taken in all morpho-physiological development phases. As a result of the conducted morpho-anatomical research, a number of secret characteristics of A. szowitziana species were determined. A. szowitziana is a perennial, 50-60 cm or more tall, with oblong leaves. Fruiting pods are numerous, erect and branching slightly above the middle. The leaves of the lower stem are stalked, 2.5-3.5 cm long. Middle stem leaves are sessile. The mesophyll leaves are amphistomatic, isolateral-palisade type, the upper and lower epidermis contains small-celled palisade tissue. The thickened epidermal cells of the stem have 2-3 layers of collenchyma, homogeneous, polygonal and thin-walled bark parenchyma. The rhizodermis roots are covered with a single layer rhizodermis, 35-45 μm thick. Underneath the rhizodermis is a single-layered exoderm, 5-6 layered bark parenchyma, endoderm and pericycle. Since there is little humidity in summer and autumn in arid zones, the root develops very intensively in the humid period. As a result of the conducted research, it was determined that the species A. szovitsiana has the nature of adaptation to the environment, which is one of the structural characteristics of the general genus.
Kastamonu’da bulunan tarihi ahşap yapıların çatı sistemlerinin incelenmesi
Authors: GÜLER İsmail Derda , TOR Önder
Published: June 2023

Bu çalışmanın amacı, Kastamonu ilinde varlığını koruyan tarihi ahşap yapıların özellikle çatılarının görünüş, tasarım ve karakteristik özellikleri hakkında bilgi verilerek çatı formu çizimleri ile şehrin mimari kimliğinin oluşmasındaki etkisini incelemektir. Bu kapsamda, Kastamonu ilinin merkezinde bulunan mimari nitelikteki 26 adet tarihi konağın ahşap çatı kısımları incelenmiştir. Yapıların çatıları incelendiğinde; iki, üç ve dört yüzeye sahip kırma, haçvari sekiz yüzeye sahip kırma, fenerli kırma çatıların bulunduğu ve tamamının geometrik formuna göre oturtma çatı özelliğinde olup aşık, mertek, payanda, göğüsleme, dikme gibi çatı elemanlarında düz ve lambalı birleştirme uygulandığı tespit edilmiştir. Çıkma, saçak süslemeleri, cihannüma gibi karakteristik özelliklerin ön plana çıktığı gözlemlenmiştir. Şehirde mevcut bulunan tarihi yapılardan ayrıcalıklı niteliğe sahip bir adet haçvari çatı tipinde konak, bir adet kule çatı tipinde konak da çalışmada yer almıştır. Sonuç olarak Kastamonu mimari kimliği oluşumunda büyük öneme sahip tarihî konakların ahşap çatıları teknik, görsel ve işlev yönünden incelenmiş ve tespitler ortaya konulmuştur.
RNA-binding is an ancient trait of the Annexin family
Authors: Patil Sudarshan S. , Panchal Vipul , Røstbø Trude , Romanyuk Sofya , Hollås Hanne , Brenk Ruth , Grindheim Ann Kari , Vedeler Anni
Published: June 2023

Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of transport vesicles and mRNA granules/complexes are closely coordinated to ensure effective simultaneous handling of all components required for a specific function, thereby minimizing the use of cellular energy. Identification of proteins acting at the crossroads of such coordinated transport events will ultimately provide mechanistic details of the processes. Annexins are multifunctional proteins involved in a variety of cellular processes associated with Ca2+-regulation and lipid binding, linked to the operation of both the endocytic and exocytic pathways. Furthermore, certain Annexins have been implicated in the regulation of mRNA transport and translation. Since Annexin A2 binds specific mRNAs via its core structure and is also present in mRNP complexes, we speculated whether direct association with RNA could be a common property of the mammalian Annexin family sharing a highly similar core structure.

Methods and results: Therefore, we performed spot blot and UV-crosslinking experiments to assess the mRNA binding abilities of the different Annexins, using annexin A2 and c-myc 3′UTRs as well as c-myc 5′UTR as baits. We supplemented the data with immunoblot detection of selected Annexins in mRNP complexes derived from the neuroendocrine rat PC12 cells. Furthermore, biolayer interferometry was used to determine the KD of selected Annexin-RNA interactions, which indicated distinct affinities. Amongst these Annexins, Annexin A13 and the core structures of Annexin A7, Annexin A11 bind c-myc 3′UTR with KDs in the nanomolar range. Of the selected Annexins, only Annexin A2 binds the c-myc 5′UTR indicating some selectivity.

Discussion: The oldest members of the mammalian Annexin family share the ability to associate with RNA, suggesting that RNA-binding is an ancient trait of this protein family. Thus, the combined RNA- and lipid-binding properties of the Annexins make them attractive candidates to participate in coordinated long-distance transport of membrane vesicles and mRNAs regulated by Ca2+. The present screening results can thus pave the way for studies of the multifunctional Annexins in a novel cellular context.
Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
Authors: Kelly Amy , Chan Jeannie , Powell Theresa L. , Cox Laura A. , Jansson Thomas , Rosario Fredrick J.
Published: June 2023

Infants born to obese mothers have an increased risk of developing obesity and metabolic diseases in childhood and adulthood. Although the molecular mechanisms linking maternal obesity during pregnancy to the development of metabolic diseases in offspring are poorly understood, evidence suggests that changes in the placental function may play a role. Using a mouse model of diet-induced obesity with fetal overgrowth, we performed RNA-seq analysis at embryonic day 18.5 to identify genes differentially expressed in the placentas of obese and normal-weight dams (controls). In male placentas, 511 genes were upregulated and 791 genes were downregulated in response to maternal obesity. In female placentas, 722 genes were downregulated and 474 genes were upregulated in response to maternal obesity. The top canonical pathway downregulated in maternal obesity in male placentas was oxidative phosphorylation. In contrast, sirtuin signaling, NF-kB signaling, phosphatidylinositol, and fatty acid degradation were upregulated. In female placentas, the top canonical pathways downregulated in maternal obesity were triacylglycerol biosynthesis, glycerophospholipid metabolism, and endocytosis. In contrast, bone morphogenetic protein, TNF, and MAPK signaling were upregulated in the female placentas of the obese group. In agreement with RNA-seq data, the expression of proteins associated with oxidative phosphorylation was downregulated in male but not female placentas of obese mice. Similarly, sex-specific changes in the protein expression of mitochondrial complexes were found in placentas collected from obese women delivering large-for-gestational-age (LGA) babies. In conclusion, maternal obesity with fetal overgrowth differentially regulates the placental transcriptome in male and female placentas, including genes involved in oxidative phosphorylation.
Improving stakeholder engagement in climate change risk assessments: insights from six co-production initiatives in Europe
Authors: André Karin , Gerger Swartling Åsa , Englund Mathilda , Petutschnig Linda , Attoh Emmanuel M. N. A. N. , Milde Katharina , Lückerath Daniel , Cauchy Adeline , Botnen Holm Tara , Hanssen Korsbrekke Mari , Bour Muriel , Rome Erich
Published: June 2023

It is increasingly recognized that effective climate risk assessments benefit from well-crafted processes of knowledge co-production involving key stakeholders and scientists. To support the co-production of actionable knowledge on climate change, a careful design and planning process is often called for to ensure that relevant perspectives are integrated and to promote shared understandings and joint ownership of the research process. In this article, we aim to further refine methods for co-producing climate services to support risk-informed decision-support and adaptation action. By drawing on insights and lessons learned from participatory processes in six case studies in Northern and Central Europe, we seek to better understand how associated challenges and opportunities arising in co-production processes play out in different case-specific contexts. All cases have applied a standardized framework for climate vulnerability and risk assessment, the impact chain method. The analysis builds on multiple methods including a survey among case study researchers and stakeholders, interviews with researchers, as well as a project workshop to develop collective insights and synthesize results. The results illustrate case studies' different approaches to stakeholder involvement as well as the outputs, outcomes, and impacts resulting from the risk assessments. Examples include early indications of mutual learning and improved understanding of climate risks, impacts and vulnerability, and local and regional decision contexts, as well as actual uptake in planning and decision contexts. Other outcomes concern scientific progress and contribution to methodological innovations. Overall, our study offers insights into the value of adopting good practices in knowledge co-production in impact chain-based climate risk assessments, with wider lessons for the climate services domain. While collaborations and interactions have contributed to a number of benefits some practical challenges remain for achieving effective co-production processes in the context of climate change and adaptation. To overcome these challenges, we propose a carefully designed but flexible and iterative participatory approach that enables joint learning; reassessment of stakeholder needs and capacities; and co-produced, actionable climate services with the potential to catalyze climate action.
Artificial intelligence as toolset for analysis of public opinion and social interaction in marketing: identification of micro and nano influencers
Authors: Gerlich Michael , Elsayed Walaa , Sokolovskiy Konstantin
Published: June 2023

In the conditions of digitalization, which has penetrated all spheres of human life and society, artificial intelligence (AI) and ultra-precise neural networks influence our thinking and form consumer demand and loyalty. Modern AI applications cover all the essential areas of activity: education, manufacturing, marketing, management, law, medicine, and e-commerce. The study aims to build a methodology for analyzing the influence of public opinion in social networks, particularly micro and nano influencers, through AI and machine learning on the effectiveness of companies' marketing activities. The authors studied the stages of consumer interaction with marketing profits and highlighted the role of AI technologies in each of them. They showed that public opinion was the main driving force for effective sales of products on the Internet. Based on empirical data, a strong direct relationship was found between the number of influencers and the dynamics of marketing profit: it was revealed that the correlation coefficients between the marketing profit index and the number of micro and nano influencers were 0.86–0.99 in all surveyed companies implementing AI technologies, regardless of the market niche. Based on the expert method, the company's marketing system is investigated. An integral indicator of its effectiveness is introduced, consisting of sub-indices of analysis, diffusion and marketing information management. The authors considered the factors of profit from marketing activities of five companies actively implementing AI in brand promotion, including those using the leadership opinions of influencers. The applied value of the developed methodology is the possibility of using it to construct Internet marketing strategies by companies. By permanently monitoring the relationship between the marketing profit index and the degree of brand popularization in social networks, companies can manage sales at all stages of consumer communications, optimizing the costs of influencers promoting products on different social platforms. The prospects for further research are to study the relationship between the degree of interactivity of the influencer with the audience, the content posted by it with the conversion rate and sales volumes; grouping and identification of influencers based on the clustering method.
Case report: Cardiac metastatic uterine intravenous leiomyomatosis excision with extracorporeal venous shunt under the guidance of 3-dimensional printing
Authors: Chen Hong , Mao Yu , Xie Hongtao , Liu Dejun , Zhang Shun , Tian Yongcang , Yang Jian , Bai Benjian
Published: June 2023

Intravenous leiomyomatosis (IVL) is relatively rare, and the incidence of cardiac IVL is even lower. The case report introduces a 48-year-old woman with two episodes of syncope in 2021. Echocardiography showed a cord-like mass in the inferior vena cava (IVC), right atrium (RA), right ventricle (RV) and pulmonary artery. Computed tomography venography and magnetic resonance imaging showed strips in RA, RV, IVC, right common iliac vein, and internal iliac vein, as well as a round-like mass in the right uterine adnexa. Combined with the patient's prior surgical history and rare anatomical structures, surgeons used cardiovascular 3-dimensional (3D) printing technology to create patient-specific preoperative 3D printed model. The model could help surgeons to visually and accurately understand the size of IVL and its relationship to adjacent tissues. Finally, surgeons successfully performed a concurrent transabdominal resection of cardiac metastatic IVL and adnexal hysterectomy with off-cardiopulmonary bypass. Preoperative evaluation and guidance of 3D printing may play a critical role to ensure this surgery for the patient with rare anatomical structures and high surgical risk.

Clinical Trial Registration: [ClinicalTrials.gov], Protocol Registration System [NCT02917980].
Influence of mechanical characteristics of deep composite salt-gypsum layers on safe drilling of directional wells: a case study of Palaeogene in the Kuqa Piedmont structure, Tarim Basin, China
Authors: Fang Chao , Li Shiyuan , Zhao Qing , Zhang Hui , Chen Zhaowei , Huang Hao , Lin Zili , Fan Jinchao , Liu Enbo
Published: June 2023

The directional wells can effectively improve the development efficiency of deep and ultra-deep pre-salt oil and gas reservoirs in the Kuqa Mountains of Tarim basin. Under the condition of deep temperature and pressure, the mechanical properties of the composite salt-gypsum layers are complex. During the directional drilling process, that the salt rock is easy to creep causes the drill stick. Under the condition of controlling the well inclination, it is difficult to choose the appropriate drilling fluid density to resist creep and thus maintain the stability of the wellbore. On the basis of rock mechanics experiments, this study established a two-dimensional finite element model considering the combination of composite salt-gypsum layers and inclined well with the effect of in-situ stress, analyzed the influence of temperature, differential stress and well deviation on the salt rock creep. The density of drilling fluid for preventing creep sticking is calculated, and a safe drilling fluid density chart for preventing creep shrinkage of composite salt-gypsum layers is compiled. The results show that when the differential stress is less than 10 MPa, the creep rate of the Tarim composite salt-gypsum layers are at least 10 times higher than that of the Gulf of Mexico salt layers; the creep rate increases with the increase of the differential stress and temperature, and the creep rate is an incremental curve; taking the highly deviated well in the Bozi area as an example, where the shrinkage ratio caused by sticking is set to be 5%, the drilling fluid density chart for creep resistance at 45° and 60° inclination is built, which is consistent with the actual drilling in the field. The results can provide design basis for the selection of anti-creep drilling fluid density in the directional wells in the Kuqa Piedmont composite salt-gypsum layers.
Failure characteristics and the law of the energy evolution of granite with different pre-crack inclination angles under uniaxial compression loading
Authors: Zhao Ercheng , Li Juhong , Zhang Xiongtian , Zhang Chunyang , Ren Qinglin , Tan Tao , Wang Yixian
Published: June 2023

Cracks affect the strength of rock masses and eventually threaten their stability in engineering. In order to study the fracture characteristics and mechanical properties of cracked rocks, uniaxial compression tests of pre-cracked granite samples with a central circular through hole were carried out by using MTS816 rock mechanics testing system. The inclination angles of different pre-cracks are 0°, 15°, 30°, 45°, 60°, 75°, and 90° respectively, and the influence of the crack stop hole near the crack tip on the failure behavior of pre-cracked samples is also considered. The results indicate that, compared with the intact sample, the peak strength of pre-cracked samples decreases significantly and is related to the pre-crack inclination angle. The failure mode of the sample varies with the pre-crack inclination angle, and the crack stop hole near the crack tip also has a certain influence on the crack growth to a certain extent. However, in terms of failure mode and its transformation law, the influence of central circular through hole and crack stop hole can be ignored. Generally speaking, the larger the inclination angle of the pre-crack, the more the total energy required for failure of the sample, and the more the stored elastic strain energy. Before the peak strength, the elastic strain energy of the sample is greater than the dissipated energy, after the peak strength, the dissipated energy gradually exceeds the elastic strain energy due to energy conversion. It is found that the pre-crack reduces the energy storage capacity of the sample, and the total energy is ultimately dominated by sample integrity. The dissipated energy rate increases first, then decreases, and finally increases again, the inflection points are the end of micro-crack closure and the peak strength, respectively. The crack stop hole changes the law of energy evolution to a certain extent, which can improve the ability of rocks to accumulate energy when designed at an appropriate position, so as to improve its load-bearing capacity in a certain range. The results display the mechanical properties of pre-cracked granite samples under uniaxial compression and are conducive to its application in engineering.
Improving e-learning websites: the role of menu depth and metacognitive support
Authors: Beege Maik , Scherer Demian , Weiß Elena
Published: June 2023

Introduction

Results from experimental research in instructional psychology imply that a deep menu structure of a e-learning website may provide useful segmentation. However, menu depth also increases the need for navigation and thus, might have impairing effects on learning. Furthermore, instructional support can be provided by including a checklist, to ensure that learners reflect on their study progress. The study aimed at investigating which menu structure is beneficial for e-learning websites and whether a checklist could compensate the negative effects of an unfavorable menu structure.

Methods

Therefore, in an online experiment, we let 101 students learn facts about rocks from an e-learning website with either a deep or a flat menu structure. We further manipulated whether metacognitive support through a checklist was provided or not. Learning outcomes, cognitive load, metacognitive factors as well as learning time were measured.

Results

Results show no main effects of the menu depth or the presence of a checklist on retention and transfer performance. Learning achievements in percent for retention were 37.31 (deep menu/checklist), 31.10 (deep menu/no checklist), 36.07 (flat menu/checklist), 38.13 (flat menu, no checklist) and for transfer were 35.19 (deep menu/checklist), 34.40 (deep menu/no checklist), 37.78 (flat menu/checklist), 33.23 (flat menu, no checklist). Yet, there are hints that the deeper menu structure had a negative effect on learning processes: The deep menu structure led to an enhanced extraneous cognitive load (ECL) and reduced learning efficiency. However, providing a checklist had beneficial effects mainly when learning with a deep menu structure but not overall. Unexpectedly, the presence of the checklist did not influence metacognitive measures.

Discussion

Our study suggests that possible costs of a deep menu structure should be considered when designing instructional checklists. However, the study also provides a way in which these costs can be compensated, which is by using a checklist. Implications for instructional research and e-learning are discussed.
Longitudinal contributions of morphological awareness, listening comprehension, and gains in word reading fluency to later word- and text-reading fluency
Authors: Metsala Jamie L.
Published: June 2023

This study examined the contributions of morphological awareness, listening comprehension, and early gains in word reading fluency to later outcomes in word- and text-reading fluency. There were 83 participants in second and third grade who were followed across 18 months. Gains in word reading fluency across the first six months predicted both word- and text-reading fluency one year later, beyond variance accounted for by initial word reading fluency, phonological awareness, rapid naming, and two oral language skills. Initial morphological awareness predicted reliable additional variance in word- and text-reading fluency 18 months later. The contribution of listening comprehension was specific to outcomes in text reading fluency. In the last analyses, listening comprehension, but not morphological awareness, predicted unique variance in final text reading fluency beyond final word reading fluency. Findings are discussed in terms of the developmental time-course of reading fluency and the roles of the two oral language skills examined.
A data-driven multidimensional assessment model for English listening and speaking courses in higher education
Authors: Xue Shuwei , Xue Xin , Son Ye Jun , Jiang Yaxuan , Zhou Hang , Chen Shifa
Published: June 2023

Based on multiple assessment approach, this study used factor analysis and neural network modeling methods to build a data-driven multidimensional assessment model for English listening and speaking courses in higher education. We found that: (1) Peer assessment, student self-assessment, previous academic records, and teacher assessment were the four effective assessors of the multi-dimensional assessment of English listening and speaking courses; (2) The multidimensional assessment model based on the four effective assessors can predict the final academic performance of students in English listening and speaking courses, with previous academic records contributing the most, followed by peer assessment, teacher assessment, and student self-assessment. Therefore, a multidimensional assessment model for English listening and speaking courses in higher education was proposed: the academic performance of students (on a percentage basis) should be composed of 29% previous academic records, 28% peer assessment, 26% teacher assessment, and 17% student self-assessment. This model can guide teachers to intervene with students who need help in a timely manner, based on various assessors, thereby effectively improving their academic performance.
The value of FT4/TSH ratio in the differential diagnosis of Graves’ disease and subacute thyroiditis
Authors: Zhang Yingjie , Wang Yu , Liu Miao , Wei Lingge , Huang Jianmin , Dong Ziqian , Guan Meichao , Wu Weijie , Gao Jianqing , Huang Xiaojie , Guo Xin , Xie Peng
Published: June 2023

Objective

To explore the value of the FT4/TSH ratio in the etiological diagnosis of newly diagnosed patients with thyrotoxicosis.

Methods

The retrospective study was conducted on 287 patients with thyrotoxicosis (122 patients with subacute thyroiditis and 165 patients with Graves’ disease) and 415 healthy people on their first visit to our hospital. All patients underwent thyroid function tests including the measurement of T3, T4, FT3, FT4, TSH, T3/TSH, and T4/TSH. The receiver operating characteristic (ROC) curve was employed to evaluate the value of FT4/TSH in the differential diagnosis of Graves’ disease and subacute thyroiditis, and compared with other related indicators.

Results

The area under the curve of FT4/TSH for diagnosing Graves’ disease and thyroiditis was 0.846, which was significantly larger than the area under the curve of T3/T4 ratio (P< 0.05) and FT3/FT4 ratio (P< 0.05). When the cut-off value of the FT4/TSH ratio was 5731.286 pmol/mIU, the sensitivity was 71.52%, the specificity was 90.16%, the positive predictive value was 90.77% and the negative predictive value was 70.06%. The diagnostic accuracy was 79.44%.

Conclusion

FT4/TSH ratio can be used as a new reference index for the differential diagnosis of thyrotoxicosis.
Untangling the spatial patterns of evolution of specialized villages and influencing factors
Authors: Niu Ning , Wang Chao , Jin He
Published: June 2023

Introduction

The development of specialized villages (SVs) is of great importance for rural revitalization.

Methods

This study integrated SVs, terrain, resource, traffic, market, and economy data to characterize the development of SVs from 2017 to 2021 and explore its influence factors by the Random Forest Regression model in Henan, China.

Results

The sustainably developed SVs were mainly distributed in the plain and the transition zone of mountain-hilly, mountain-plain, and hilly-plain, showing a spatially aggregated polycentric characteristic; the market is the key factor for the development of SVs in the transition zone of mountain-hill or mountain-plain, and the traffic factor mainly influences SVs in the plain and the transition zone of hill-plain; compared to the factors influencing the formation of SVs, the influence of terrain and traffic factors on the development of SVs was decreasing, and the influence of market and economic factors was showing an increasing trend.

Discussion

The results of this study can provide practical strategies for the development of SVs in the under-developed areas of interior.
Relationships between microplastic pollution and land use in the Chongqing section of the Yangtze River
Authors: Ye Sheng , Pei Desheng
Published: June 2023

Microplastic (MP) pollution is an emerging environmental issue. While it is evident that human activities are the primary source of MP pollution, the relationship between land use and MP pollution in rivers requires further study. Using data from 26 MP monitoring sites in the Chongqing section of the Yangtze River, we analyzed MP data along with land use and construction data. We improved the model for the Land Use Intensity Composite Index (LUI) to obtain correlations between land use and MP pollution. We found: 1) The concentration of microplastics in surface water (MPsw) in the Chongqing section of the Yangtze River gradually declined from upstream (central urban section of Chongqing) to downstream (northeastern section of Chongqing). 2) From 2016 to 2020, MPsw in the Chongqing section of the Yangtze River decreased by about 7.5-fold. 3) MPsw in the Chongqing section of the Yangtze River was positively correlated with the amount of surrounding urban and garden land. When the buffer radius was 1 km, the correlation coefficient was 0.53 (p < 0.05). With increasing buffer radius, the correlation between land use and gradually weakened. 4) The LUI was also strongly correlated with MPsw. The correlation was strongest when the buffer radius was 1 km, with a correlation coefficient of 0.59 (p < 0.05). At all buffer scales, microplastics in sediments (MPss) was positively correlated with village land and arable land . Unlike MPsw, as the buffer radius increased, the strength of the correlations between land use types and MPss gradually increased. The LUI was strongly correlated with MPsw . As the buffer radius increases, the correlation between the two gradually weakens. These results provide information useful for remediation and reduction of MP in river systems.