bluuebunny/crossref_metadata_2025 huggingface dataset:
Uma cartografia do fandango
Authors: Bergmann Filho Juarez
Published: February 2023

O presente ensaio é parte fragmentada de um capítulo imagético da tese de doutorado em Design intitulada “Artífices, Artifícios e Artefatos: Narrativas e trajetórias no processo de construção da Rabeca brasileira”. Meu objetivo principal foi aproximar o leitor do Universo de Pesquisa retratado. Na tese proponho uma narrativa visual do circuito de produção, circulação e uso de Rabecas naquele Universo de Pesquisa. Apresento uma das coleções de imagens divididas a partir de um bloco temático que retrata uma cartografia local, explicitando os locais e caminhos deste circuito e evidenciando os modos de fazer e performatizar do Fandango Paranaense. Neste caminhar imagético, entre a cidade portuária de Paranaguá e a Ilha dos Valadares, no litoral do estado do Paraná, me chamou a atenção às diversas janelas tanto dos casarões coloniais quanto das propriedades rurais pareciam me observar no meu caminhar. Desta forma, serviram de moldura para a composição das imagens, por vezes restringindo a visão e por vezes sendo atravessada por ela. Desta forma, artífices e artefatos constituem-se no circuito de produção, circulação e uso na performance do Fandango na Ilha dos Valadares, PR, por meio de um processo dinâmico e complexo de negociação social entre sujeitos/sujeitos, sujeitos/artefatos e por vezes artefatos/artefatos.
“Aqui eu quero puta, místico, freira, ateu, comunista”
Authors: Bort Junior João Roberto , Brandão Carlos Rodrigues
Published: February 2023

Carlos Rodrigues Brandão é antropólogo, mas também psicólogo. Com ampla trajetória acadêmica, a lista de universidades do Brasil e do exterior às quais esteve e está vinculado é vasta o suficiente para inibir nossa tentativa de reproduzi-la. Mas, aparentemente, foi na Universidade Estadual de Campinas que construiu a maior parte de sua trajetória, ainda inacabada, afinal, continua produzindo. Referência obrigatória para os estudiosos, principalmente do mundo rural e da Educação, Brandão escreveu livros que enveredam para além da Antropologia, versam sobre temas ligados à Arte, ao Meio Ambiente e à Literatura, inclusive a infantil. O Humano com toda sua potência de vida múltipla é matéria de pensamento do autor, como fica evidente no curso livre e aberto que, atualmente, coordena em seu sítio em Caldas, no Sul Mineiro. Nas palavras dele, um curso que é um “encontro entre pessoas sobre o mistério da pessoa”.
Como nos tornamos quem somos
Authors: Regitano Aline de Paula , Toren Christina
Published: February 2023

Professora emérita do Departamento de Antropologia Social da University of St. Andrews e diretora fundadora do Centre for Pacific Studies, Christina Toren tem atuado de modo determinante no traçado dos novos rumos da antropologia contemporânea. Suas contribuições aos estudos de Fiji/Pacífico, socialidade, parentesco e noções de pessoa, ontogenia como processo histórico, e epistemologia, são notáveis, e nortearam profundas reformulações teóricas em todo o mundo. Nos encontramos para esta entrevista em sua casa em Dundee, na Escócia, no período em que ela supervisionava uma pesquisa que desenvolvemos na University of St. Andrews.
Implementation of mobile augmented reality on physics learning in junior high school students
Authors: Rahmat Anggi Datiatur , Kuswanto Heru , Wilujeng Insih , Perdana Riki
Published: February 2023

Technology has an essential role in the educational field. Technology-based mobile has the potential to improve education through Augmented Reality (AR). This study investigates the effect of mobile augmented reality on physics learning achievement and students' opinions on using this technology. The study used a convergent parallel pattern from mixed-method models in which quantitative and qualitative data are collected simultaneously and analyzed independently. The study participants are 64 (7th-grade students) who are learning solar system concepts at one of the junior high schools in West Java Province, Indonesia. This study collects pre- and post-test data as quantitative data to analyze students' learning achievement using the normalized gain score. The result showed that the students using mobile augmented reality have higher criteria for learning achievement than those using textbooks. The qualitative data was collected from interviewed students after using mobile augmented reality and analyzing using descriptive analysis. The results of the student opinion state that augmented reality is a new learning environment that effectively helps them understand physics concepts, enhances students' learning achievement and helps concretize abstract concepts through visual 3D simulations. Moreover, according to the study, students find it easier to understand physics concepts after using mobile augmented reality.
Examining Dimensionality and Validity of the Academic Integrity Survey Instrument
Authors: Zhang Zhidong , Garcia Luis
Published: February 2023

Dimensional reduction is one of the methods to ensure the quality of a questionnaire. This study examined two methods to reduce the dimension of the questionnaire: multidimensional scaling (MDS) and exploratory factor analysis (EFA). The questionnaire, Awareness of Academic Dishonesty consists of 30 questions. Participants included 110 college students. Multidimensional scaling analysis reduced the multidimensions to essentially two dimensions. The exploratory factor analysis reduced the multidimensions to three dimensions. MDS allowed the researchers to evaluate the questionnaire items by looking at the similarities of these data points. EFA provided an alternative thought about the construct of the questionnaire.
TERRITORIALIDADE DOS JENIPAPO-KANINDÉ NA REGIÃO METROPOLITANA DE FORTALEZA/CE
Authors: Bomtempo Denise Cristina , Soares Ilana Maria Braga
Published: February 2023

A finalidade deste trabalho é apresentar a territorialidade dos Jenipapo-Kanindé, da Terra Indígena Lagoa da Encantada, localizada na Região Metropolitana de Fortaleza/CE. Para tanto, fizeram-se necessários os seguintes procedimentos metodológicos: levantamento bibliográfico; leitura e interpretação de dados secundários; organização de cartogramas e tabelas, bem como realização de trabalhos de campo que contou com observação da paisagem e entrevista com integrantes da comunidade indígena investigada. Tivemos como resultado a identificação da territorialidade, salientando a organização territorial, o perfil populacional, o sistema de ensino, o perfil e distribuição das moradias, as áreas de lazer, as associações e a estruturação econômica dos Jenipapo-Kanindé. Diante do apresentado, concluímos que a territorialidade da população investigada se constitui com base num crescimento populacional positivo e numa formação grupal pautada na produção de uma economia agrícola coletiva e num sistema de ensino que possibilita o fortalecimento da identidade indígena. Constatamos ainda a existência de uma organização habitacional aos padrões urbanos coexistindo com rugosidades em relação ao padrão das construções. Verificamos também as territorialidades por meio da atuação das associações, enquanto espaços de convivência e lugar em que se faz presente o protagonismo da mulher indígena. Por fim, constatamos a existência de uma Geografia dos povos originários diversa, protagonista e resistente frente à ação dos agentes hegemônicos.
Lacrimal Gland Prolapse: Case Report
Authors: Naing Ei Ei , Myint Khin Thandar , Roddi Roberto
Published: February 2023

Lacrimal Gland Prolapse is an important diagnosis to exclude in patients presenting with lateral upper eyelid fullness. Prolapse of the lacrimal gland is the descend of the lacrimal gland into the anterior orbit. It could be responsible for blepharoptosis and unattractive appearance. This is a case report of a young patient with lacrimal gland prolapse who has been treated by repositioning with suture in an outpatient surgical setting.
Antiviral Activities of Streptomyces KSF 103 Methanolic Extracts Against Dengue Virus Type-2
Authors: Zulkifli Nurfatihah , Khairat Jasmine Elanie , Azman Adzzie Shazleen , Baharudin Nur-Faralyza Mohd , Malek Nurul Adila , Zainal Abidin Syafiq-Asnawi , Bakar Sazaly Abu , Hassandarvish Pouya
Published: February 2023

Dengue has long been a serious health burden to the global community, especially for those living in the tropics. In spite of the availability of vaccines, effective treatment for the infection is still needed and currently remained absent. In the present study, antiviral properties of the KSF 103 ME which consisted of a number of potential antiviral compounds were investigated against DENV-2. The effects of this extract against DENV-2 replication were determined using the qRT-PCR. Findings from the study suggested that the KSF 103 ME showed maximum inhibitory properties toward the virus during the virus entry stage at concentrations of more than 12.5 µg/mL. Minimal antiviral activities were observed at other virus replication stages; adsorption (42% reduction at 50 µg/mL), post-adsorption (67.6% reduction at 50 µg/mL), prophylactic treatment (68.4% and 87.7% reductions at 50 µg/mL and 25 µg/mL, respectively) and direct virucidal assay (48% and 56.8% reductions at 50 µg/mL and 25 µg/mL, respectively. The KSF 103 ME inhibited dengue virus repication with an IC50 value of 20.3 µg/mL and SI value of 38.9. The KSF 103 ME showed potent antiviral properties against DENV during the entry stage. Further studies will be needed to deduce the antiviral mechanisms of the KSF 103 ME against DENV.
APPLICATION OF THE TEST METHOD – COMPARATIVE IN DESIGN PRACTICE. CASE STUDY – WOŁOMIN
Authors:   Politechnika Bydgoska im. Jana i Jędrzeja Śniadeckich, Poland Wydział Budownictwa, Architektury i Inżynierii Środowiska Katedra Architektury i Urbanistyki, Rosiak Łukasz
Published: February 2023

The aim of the article is to present how designers, during public consultations, use the potential of variant analyzes in urban design. Designers select strategically important places where it is possible to consider introducing alternative solutions. They separate the "healthy" tissue, stating that its condition is suitable for being left behind, use a variant model, and are able to present solutions that are objectively similar in quality to each other. In this work, the author will try to explain the importance of the variant design process. For this purpose, he will use the example of developing a local revitalization plan for the so-called "Old Town" of the city of Wołomin.
Retrospective Analysis of Associated Anomalies in 636 Patients with Operatively Treated Congenital Scoliosis
Authors: Wu Nan , Liu Lian , Zhang Yuanqiang , Wang Lianlei , Wang Shengru , Zhao Sen , Li Guozhuang , Yang Yang , Lin Guanfeng , Shen Jianxiong , Wu Zhihong , Qiu Guixing , Zhang Terry Jianguo
Published: February 2023

Update

This article was updated on December 22, 2023, because of a previous error. Specifically, there was an error in one of the grant numbers mentioned in the article. In the Source of Funding paragraph, the text that had previously read “2022-PUMCH-D-007” now reads “2022-PUMCH-D-004.”

An erratum has been published: J Bone Joint Surg Am. 2024 Feb 7;106(3):e8.

Background:

Congenital scoliosis is frequently associated with anomalies in multiple organ systems. However, the prevalence and distribution of associated anomalies remain unclear, and there is a large amount of variation in data among different studies.

Methods:

Six hundred and thirty-six Chinese patients who had undergone scoliosis correction surgery at Peking Union Medical College Hospital from January 2012 to July 2019 were recruited, as a part of the Deciphering disorders Involving Scoliosis and COmorbidities (DISCO) study. The medical data for each subject were collected and analyzed.

Results:

The mean age (and standard deviation) at the time of presentation for scoliosis was 6.4 ± 6.3 years, and the mean Cobb angle of the major curve was 60.8° ± 26.5°. Intraspinal abnormalities were found in 186 (30.3%) of 614 patients, with diastematomyelia being the most common anomaly (59.1%; 110 of 186). The prevalence of intraspinal abnormalities was remarkably higher in patients with failure of segmentation and mixed deformities than in patients with failure of formation (p < 0.001). Patients with intraspinal anomalies showed more severe deformities, including larger Cobb angles of the major curve (p < 0.001). We also demonstrated that cardiac anomalies were associated with remarkably worse pulmonary function, i.e., lower forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF). Additionally, we identified associations among different concomitant malformations. We found that patients with musculoskeletal anomalies of types other than intraspinal and maxillofacial were 9.2 times more likely to have additional maxillofacial anomalies.

Conclusions:

In our cohort, comorbidities associated with congenital scoliosis occurred at a rate of 55%. To our knowledge, our study is the first to show that patients with congenital scoliosis and cardiac anomalies have reduced pulmonary function, as demonstrated by lower FEV1, FVC, and PEF. Moreover, the potential associations among concomitant anomalies revealed the importance of a comprehensive preoperative evaluation scheme.

Level of Evidence:

Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
What Program Characteristics Are Associated with Resident Racial Diversity in Orthopaedic Surgery? An Analysis of Association of American Medical Colleges Data
Authors: Shah Kalpit , Zhuang Thompson , Scott Brandon , Sobel Andrew , Akelman Edward
Published: February 2023

Background:

In orthopaedic surgery, there are fewer Black or African American (4%) and Hispanic or Latino (4%) residents compared with general surgery, internal medicine, family medicine, and pediatrics (5%-7% Black residents and 7%-9% Hispanic/Latino residents, respectively). There are also fewer underrepresented in medicine minority (URiM) faculty in orthopaedic surgery (6.1%) compared with general surgery (8.9%), otolaryngology (7.8%), internal medicine (9.7%), and obstetrics and gynecology (15.6%). Identifying program characteristics that are associated with the percentage of URiM residents could reveal strategies for improving diversity.

Methods:

Using Association of American Medical Colleges orthopaedic resident and faculty race/ethnicity data from 2007 to 2016, we analyzed the racial diversity of 166 of 207 residency programs. The primary outcome was program racial diversity, measured as the percentage of URiM residents per program. The top quartile of programs was compared with the other quartiles. Characteristics analyzed included percentage of URiM faculty, affiliation with a university/top 40 medical school/top 40 orthopaedic hospital, geographic region, city type, and city size. We used a multivariable linear regression model to evaluate program characteristics associated with diversity and a linear mixed-effects model with program-specific random effects to evaluate time trends.

Results:

The mean percentage of URiM residents per program was 9.3% (SD = 10.5%). In the top quartile of programs, URiM residents composed 20.7% ± 2.5% of the program compared with 5.8% ± 0.3% in other quartiles (p < 0.001). After adjusting for program and faculty size, the only factor associated with the number of URiM residents per program was the number of URiM faculty. For every 5 additional URiM faculty members, there was an associated increase in the number of URiM residents per program by 3.6 (95% confidence interval [CI]: 2.3-5.0). There was a small but statistically significant annual increase in the percentage of URiM residents per program of 0.207 (95% CI: 0.112-0.302) percentage points during the study period.

Conclusion:

URiM representation remains low among orthopaedic residents. Efforts to increase the URiM faculty base represent a potential strategy for programs to increase URiM representation among residents by attracting more diverse applicants.
Absenteísmo e custos indiretos por transtornos mentais no serviço público federal brasileiro
Authors: Santos Douglas , Chaoubah Aldredo , Oliveira Helian , Guerra Maximiliano , Silva Patrícia
Published: February 2023

Objetivo: Esta pesquisa objetiva estimar os custos econômicos indiretos decorrentes dos transtornos mentais (TMs) entre servidores públicos federais, no período entre janeiro de 2012 e dezembro de 2017. Métodos: Trata-se de um estudo ecológico, de delineamento longitudinal retrospectivo e caráter exploratório. Utilizou-se a Abordagem do Capital Humano para o cálculo do custo indireto. Resultados: Os TMs foram responsáveis por 5.664.800 dias concedidos de licença ao longo de todo o período, resultando em custo indireto estimado em R$ 1.889.554.416,60, dos quais os transtornos do humor e ansiosos representaram os maiores custos. Conclusões: Este estudo demonstrou a relevância dos TMs para essa comunidade de servidores, bem como revelou a dimensão dos impactos econômicos decorrentes do absenteísmo, o que pode possibilitar, às instâncias gestoras e aos profissionais envolvidos com a saúde do servidor público federal, melhor compreensão dos custos dos TMs, direcionando-os ao planejamento de intervenções mais acertadas.
Análise de custo-efetividade do uso de inibidores da via de sinalização mTOR x micofenolato em receptores de transplante renal sem profilaxia para citomegalovírus
Authors: Magacho Flávia , Chaoubah Alfredo , Ferreira Gustavo , Fernandes Guilherme , Tassi Juliana , Colares Vinícius , Avelino Natália , Gonçalves Patrícia
Published: February 2023

Objetivo: Avaliar a relação de custo-efetividade dos regimes imunossupressores utilizados em pacientes receptores de transplante renal, no Hospital Santa Casa de Misericórdia de Juiz de Fora, MG, basiliximabe, micofenolato de sódio, tacrolimo e prednisona (Grupo 1 = 93 pacientes), comparados com a associação de timoglobulina, everolimo, tacrolimo e prednisona (Grupo 2 = 91 pacientes). Métodos: Para a análise farmacoeconômica, foi utilizado o modelo de Árvore de Decisão, desenvolvido no software Treeage Suite 2011. Foi considerada uma coorte real de pacientes submetidos ao transplante renal entre janeiro de 2013 e março de 2017, os quais foram acompanhados por um período de um ano, sendo mensurados os benefícios clínicos, bem como os custos associados, na perspectiva do Sistema Único de Saúde. O método de custeio utilizado foi o botton-up. Foram adotados os limiares de custo-efetividade (LCEs) equivalentes a 1 PIB per capita e 1 a 3 PIB, considerando o ano de 2017. Resultados: No que diz respeito à sobrevida, a RCEI foi de cerca de R$ 214.234,12 para 1 ano de vida ganho. Em relação aos eventos adversos, a RCEI foi de cerca de R$ 43.682,98 para 1 ano sem incidência de eventos adversos. Conclusões: Ao avaliar a sobrevida e a incidência de eventos adversos, timoglobulina+everolimo não é considerado custo-efetivo em relação ao esquema contendo basiliximabe+micofenolato de sódio diante do LCE de 1 PIB per capita. No entanto, ao adotarmos o LCE até 3 PIB per capita, o regime contendo timoglobulina+everolimo é custo-efetivo, ultrapassando cerca de 38% do PIB per capita.
Análise do impacto das ações judiciais em um setor de referência de um hospital de grande porte de Juiz de Fora
Authors: Gonçalves Patrícia , Chaoubah Alfredo , Fernandes Guilherme , Loures Fabiano , Ortega Guillermo , Magacho Flávia , Avelino Natália
Published: February 2023

Objetivo: Avaliar o impacto das ações judiciais no setor de ortopedia da Santa Casa de Juiz de Fora/ MG. Métodos: Foi realizada análise dos prontuários dos pacientes que passaram por cirurgia no setor de ortopedia da Santa Casa de Juiz de Fora no ano de 2016. E, logo após, os pacientes advindos de ação judicial foram identificados, dividindo-se, assim, a amostra em dois grupos. As variáveis analisadas foram: sexo e idade do paciente; tempo de internação, desfecho e custos, os quais foram desmembrados em diárias, honorários, procedimentos e materiais e medicamentos. Resultados: Os resultados demonstraram que os pacientes que realizaram cirurgias por via judicial são, em sua maioria, idosos, com leve predominância do sexo masculino. A maior das demandas é para a garantia de cirurgias do sistema osteomuscular de membros inferiores, representando 65,9% das cirurgias realizadas por ação judicial em 2016, que também são as cirurgias mais demandadas por via convencional. O custo direto das cirurgias por processos judiciais foi estimado em R$ 2.340.301,68. As diárias apresentaram o maior custo, sendo responsáveis por 90,7% de todo o custo estimado. Conclusão: A judicialização neste estudo expõe deficiências do Sistema Único de Saúde quanto à oferta de serviços, uma vez que todas as cirurgias demandadas por meio de ação judicial já são contempladas pelo sistema público de saúde. Assim, os aspectos judiciais da saúde, tais como a individualidade e os prazos para cumprimento, prevalecem sobre o coletivo e os que esperam nas filas.
Desafios globais na avaliação de tecnologias em saúde dos dispositivos médicos personalizados impressos em 3D
Authors: Toscas Fotini , Ferreira Filho José Alberto , Saad Luiz Alexandre
Published: February 2023

Objetivo: Consolidar as informações de aspectos regulatórios, de desenvolvimento e implicações para avaliação dos dispositivos médicos personalizados. Métodos: Foram realizadas buscas nas agências internacionais de avaliação de tecnologias e consulta aos documentos de harmonização sanitária e estudos públicos de análise de impacto regulatório realizados por agências regulatórias de diversos países. Resultados: Ainda não há evidências científicas robustas sobre a eficácia e a segurança de dispositivos impressos em 3D; isso significa que o paciente deve ser suficientemente informado para poder dar consentimento válido. A quantidade e a qualidade atuais das evidências e as características exclusivas dessas tecnologias podem apresentar desafios na realização de avaliações de tecnologias abrangentes. Conclusão: O uso dos dispositivos médicos personalizados impressos em 3D tem grande potencial no setor de saúde, especialmente nos tratamentos de condições específicas de pacientes em que não há tecnologias comercialmente disponíveis, porém o estado da evidência pode ser uma barreira para sua adoção nos serviços de saúde. De forma a viabilizar o intercâmbio de informações e contribuir para a pesquisa colaborativa, a adoção de termo comum nos estudos é imprescindível. A falta de consenso sobre a terminologia pode apresentar desafios para a elaboração de estudos de avaliação de tecnologias que realizam buscas dependentes de estratégias de pesquisa e revisão da literatura, como avaliações econômicas e revisões sistemáticas.
Analysis of micro-costing through the Time-Driven Activity-Based Costing (TDABC) method in viscosupplementation procedures in different application regimens
Authors: Ramos Leonardo , Cohen Moisés , Araújo Denizar
Published: February 2023

Objective: To evaluate the micro-costing of viscosupplementation procedures compared to different infiltration regimens. Methods: This study compared, through the Time-Driven Activity-Based Costing method, the micro-costing of these different application regimens using national cost averages as a basis for calculation in a medium-sized outpatient service. Results: The results demonstrated that the difference in costs with the single application is 31.47% less for three and 119.13% for five applications. Conclusions: No study showed a superiority of the five-application regimen over the three-application regimen, which leads one to believe that there is no justification for this procedure from an economic or quality-of-life point of view.
Risk of acute kidney injury and cost-effectiveness analysis comparing vancomycin and linezolid for the treatment of pediatric patients infected with Gram-positive bacteria
Authors: Oliveira Laiane , Ricieri Marinei , Fachi Mariana , Okumura Lucas , Motta Fábio
Published: February 2023

Objective: This study aimed to compare the occurrence of acute kidney injury (AKI) in pediatric patients who used vancomycin (VAN) or linezolid (LNZ) to treat Gram-positive coccus (GPC) infections and to assess which treatment (VAN or LNZ) is the most cost-effective considering a pediatric hospital perspective. Methods: A retrospective cohort was performed to evaluate the occurrence of nephrotoxicity in pediatric patients without previous AKI, with GPC infections that used LNZ, or VAN monitored by serum VAN levels. Initially, descriptive analysis and Fisher and chisquare test were performed for this comparison. Then, a cost-effectiveness analysis was conducted through a decision tree model. The outcomes of interest were the rate of AKI related to the drug and the rate of admission to the intensive care unit (ICU) and cure. Results: In patients without previous acute kidney injury (AKI), 20% developed nephrotoxicity associated with VAN versus 9.6% in the LNZ group (p = 0.241). As there was no difference in nephrotoxicity between VAN andlinezolid (LNZ), vancomycin (VAN) monitored by serum VAN levels can optimize and rationalize the treatment. The nephrotoxicity risk criterion should not guide the prescription for LNZ. Furthermore, the average global cost of treatment with VAN was approximately R$ 43,000, while for LNZ, it was R$ 71,000. Conclusion: VAN was considered dominant (lower cost and greater effectiveness) over LNZ for treating patients with GPC infection.
Escore de Valor em Saúde (EVS): Uma proposta para mensuração de valor dentro de um sistema de saúde
Authors: Abicalaffe César Luiz , Araujo Gabriela , Ribas Luiz Fernando , Cabral Ângelo
Published: February 2023

Um sistema de saúde baseado em valor deverá entregar os melhores desfechos possíveis ao paciente, desfechos que realmente importam para ele, ao menor custo possível. O conceito é relativamente fácil de entender, mas a métrica para a sua demonstração tem sido um grande desafio dos sistemas de saúde. O presente artigo demostra a criação de um Escore de Valor em Saúde (EVS) utilizando Análise de Decisão por Multicritério, o qual pode ser aplicado em qualquer sistema de saúde para avaliar profissionais, serviços de saúde e linhas de cuidado de pacientes com condições clínicas específicas.
Innovative Concept of Severe Plastic Deformation Manufacturing System to Enhance Classic Equal Channel Angular Drawing Method: a Preliminary Study for Flexible Manufacturing System Looking to Industry 4.0
Authors: CARUSO SERAFINO , Filice Luigino
Published: February 2023

Equal channel angular drawing (ECAD) represents the most successful severe plastic deformation (SPD) technique for continuous industrial manufacturing of longer wires, with a constant cross-section, characterized by smaller diameters and better mechanical properties (i.e. high strains and hardness) mainly attributed to the grain size refinement. In this paper an advanced innovative concept to impose SPD, on commercial 1370 pure aluminium wires (Al 99.7%), is proposed to improve the flexibility of the classic manufacturing method of ECAD by controlling and regulating process parameters in real time to obtain several combinations of mechanical properties and to increase manufacture productivity. This paper provides a preliminary analysis of mechanical and microstructural changes occurring during ECAD process and, preserving the principle of the ECAD method, describes an innovative concept of plastic deformation showing the potential improvements to practice. The proposed manufacturing system has been validated by finite element analysis (FEA) implementing a flow stress empirical model, that includes the influence of the grain size change, for the material behaviour and two customized user-subroutines for predicting grain refinement and hardness variation. The study demonstrates the possibility to renew the classic industrial techniques within an Industry 4.0 ecosystem.
Latent classes of substance use across three age groups and associations with criminality and use of healthcare services – a record linkage study
Authors: Karsberg Sidsel , Charak Ruby , Pedersen Michael Mulbjerg , Hesse Morten
Published: February 2023

Background: Consequences of substance use depend, not only on the volume of consumption, but also on patterns of use. Yet, little research on community population samples has examined differential patterns of licit and illicit substance use that can inform prevention and treatment efforts in different developmental stages. This study identifies distinct patterns of substance use across three age groups and compares classes on risk of criminal convictions and use of health care services. Methods: Data from a large Danish survey (n=8837) was used to identify patterns of use among adolescents (15 to 18 years), emerging adults (19 to 30 years), and adults (31 to 65 years). The survey data were linked with Danish health registry data and multivariate Cox regressions were performed to examine associations between substance use class memberships, criminal convictions and use of substance-related healthcare services.
Results: Across the three age groups, latent class analyses revealed three substance use classes: a low use class, a recent binge drinking and lifetime cannabis use class, and a polysubstance use class. Across age groups, polysubstance use was associated with a markedly higher risk of criminal convictions and use of health care services. For adolescents and adults, the “recent binge drinking and lifetime use of cannabis” class, was also associated with a higher risk for criminal convictions. Conclusions: The present research provides insight into longitudinal outcomes of substance use patterns by using a large population sample and register-based data linkage. Although similarities in substance use across age groups were identified, the study also showed important differences in use that could be used to guide future interventions aimed at different age groups.
Inheriting Entrepreneurial Values and Family Business in Indonesia: Lessons from the Literature.
Authors: sukamdani nugroho b budisatrio
Published: February 2023

This paper aims to review the literature on how family values, particularly the entrepreneurship values of business founders, are inherited by the next generation of their families and reflected in the corporate culture. Indonesian Family Businesses are selected to provide a contextualized understanding through case studies. Data were collected from the Scopus database using the keywords “family business” and “Indonesia” and then analyzed to provide the dynamics of knowledge production through bibliographic analysis. In addition, a narrative literature review (NLR) was employed to reveal insights from the database. The findings show that Indonesian discussion on family businesses is emergent and ripe for study, and since 2015, interest in exploring family businesses has grown. Literature illuminates essential insights on how entrepreneurship emerged in the context of its inheritance by the next generation, which affects the corporate culture. For Indonesian family businesses, particularly Chinese family businesses, entrepreneurial spirits emerge because of the socio-cultural dynamics that use cultural values and ethics to facilitate economic activity in contemporary society. Their migration from China to Indonesia several decades ago may have aroused a spirit of survival, enacted in the second generation by sending them overseas and driving them to be involved in the business. The literature also demonstrates that each company reflects the entrepreneurial spirit and values of its founder or family through its corporate identity, institutional standards of behavior, and ethics. This research enriches the present discussion and provides insights for researchers on the research gap in family business issues. At a practical level, this paper provides insight for professionals who work in the sector to gain insight into how family businesses work to maintain their entrepreneurial spirit.
SUZ12/CXCR7 axis promotes invasion potential and is associated with portal vein tumor thrombus in hepatocellular carcinoma
Authors: Zheng Tang-hui , Zhou Xing-Hao , Zheng Su-Su , Chen Hong , Li Jingru , Cai Chen , Xia Li-Xin , Xue Tong-Chun
Published: February 2023

Background
Polycomb protein suppressor of zeste 12 (SUZ12) has been widely revealed involving in development and diverse physiopathology processes. However, the roles of SUZ12 in hepatocellular carcinoma (HCC) remain largely unknown.
Methods
Tissue microarray was used to examine the expression level of SUZ12. The gain- and loss- of function analysis were conducted to evaluate the effects of SUZ12 on the proliferation, migration and invasion of HCC cells. Meanwhile, luciferase reporter assay and RT-PCR assay were conducted to examine the effect of SUZ12 on transcriptional activity of chemokine receptors 7 (CXCR7).
Results
The expression level of SUZ12 was positively associated with HCC development, as revealed by tissue microarray analysis. Further gain- and loss- of function analysis demonstrated that SUZ12 promoted the proliferation, migration and invasion of HCC. Mechanistically, we found that SUZ12 could upregulate the expression of CXCR7 at the transcriptional level in HCC cells, and CXCR7 was revealed to contribute to the tumor-promoting roles of SUZ12. Of interest, luciferase reporter assay revealed SUZ12 positively controlled the CXCR7 via direct promoter combination but not epigenetic suppression. Moreover, high SUZ12 expression was positively correlated with CXCR7 in advanced patients with portal vein tumor thrombus.
Conclusion
Our findings indicate that SUZ12 plays pro-oncogenic roles in the progression of HCC, partially by activating CXCR7 signaling, especially in HCC patients with portal vein tumor thrombus. The SUZ12/CXCR7 axis may serve as a potential therapeutic target for treatments of advanced HCC patients.
Performances of artificial intelligence in detecting pathologic myopia: a systematic review and meta-analysis
Authors: Zhang Yue , Wang Jianing , Li Hui , Zhang Jinrong , Liu Jing , Yu Xiaobing
Published: February 2023

Background and objective Pathologic myopia (PM) is a major cause of severe visual impairment and blindness, and current applications of artificial intelligence (AI) have covered the diagnosis and classification of PM. This meta-analysis and systematic review aimed to evaluate the overall performance of AI-based models in detecting PM and related complications.
Methods We searched PubMed, Scopus, Embase, Web of Science and IEEE Xplore before November 20, 2022, for studies evaluating the performance of AI in the detection of PM based on fundus or optical coherence tomography (OCT) images. The methodological quality of included studies was evaluated using the Quality Assessment for Diagnostic Accuracy Studies (QUADAS-2). We conducted pooled for the included studies using a random effects model.
Results22 studies were included in thesystematic review,and 14 of them were included in the quantitative analysis. For the detection of PM, the summary area under the receiver operating characteristic curve (AUC) was 0.99 (95% confidence interval (CI) 0.97 to 0.99), and the pooled sensitivity and specificity were 0.95 (95% CI 0.92 to 0.96) and 0.97 (95% CI 0.94 to 0.98), respectively. For the detection of PM-related choroid neovascularization (CNV), the summary AUC was 0.99 (95% CI0.97 to 0.99).
Conclusion Our review demonstrated the excellent performance of current AI algorithms in detecting PM patients based on fundus and OCT images, and AI-assisted automated screening systems are promising for ameliorating increasing demands in clinical settings.
Risk pre-control mechanism of mines based on evidence-based safety management and safety big data
Authors: Wang Jiachuang , Guo Jiang
Published: February 2023

The overexploitation of mineral resources and the heavy use of mineral resources have caused serious environmental damage. The growing problem of mine safety also directly threatens the personal safety of the surrounding population and hinders the development of the local economy. Evidence-based safety eliminates the reliance on intuition and unsystematic aspects of traditional safety management systems by taking into account the actual production situations on site, making safety decision-making activities more scientific. However, there is frequently a lag in the transformation and feedback of evidence information, which obstructs the realization of effective safety decision-making activities. From the perspective of process safety management risk analysis and the transformation of safety big data and safety evidence, this paper proposes a new mine risk pre-control mechanism. First and foremost, based on process safety management, evidence-based safety is successfully applied to mine risk control. Secondly, from the perspective of information transformation, a mine risk pre-control mechanism based on evidence-based safety management and safety big data is established. Finally, taking mine open area monitoring as an example, the application analysis of the mine risk pre-control mode constructed above is carried out. The risk pre-control mechanism proposed in this paper provides a new idea for the practice of mine risk management.
Dynamic Metastable Polymersomes: Towards Continuous Flow Manufacturing
Authors: Wong Chin Ken , Lai Rebecca , Stenzel Martina
Published: February 2023

Polymersomes are polymeric analogues of liposomes with exceptional physical and chemical properties. Despite being dubbed as next-generation vesicles since their inception nearly three decades ago, polymersomes have yet to experience translation into the clinical or industrial settings. This is due to a lack of reliable methods to upscale production without compromising control over polymersome properties. Herein we report a continuous flow methodology capable of producing near-monodisperse polymersomes at scale (≥3 g/h) with the unprecedented option of performing downstream polymersome manipulation. Unlike conventional polymersomes, our polymersomes exhibit metastability under ambient conditions, persisting for a lifetime of ca. 7 days, during which polymersome growth occurs until a dynamic equilibrium state is reached. We demonstrate how this metastable state is key to the implementation of downstream processes to e.g., manipulate polymersome size and/or shape in the same continuous stream. The methodology operates in a plug-and-play fashion and is applicable to various block copolymers.
Automatic Deep Learning-Based Pleural Effusion Segmentation in Lung Ultrasound Images
Authors: Vukovic Damjan , Wang Andrew , Antico Maria , Steffens Marian , Ruvinov Igor , Sloun Ruud JG van , Canty David , Royse Alistair , Royse Colin , Haji Kavi , Dowling Jason , Chetty Girija , Fontanarosa Davide
Published: February 2023

Point-of-care lung ultrasound (LUS) allows real-time patient scanning to help diagnose pleural effusion (PE) and plan further investigation and treatment. LUS typically requires training and experience from the clinician to accurately interpret the images. To address this limitation, we previously demonstrated a deep-learning model capable of detecting the presence of PE on LUS at an accuracy greater than 90%, when compared to an experienced LUS operator. This follow-up study aimed to develop a deep-learning model to provide segmentations for PE in LUS. Three thousand and forty-one LUS images from twenty four patients diagnosed with PE were selected for this study. Two LUS experts provided the ground truth for training by reviewing and segmenting the images. The algorithm was then trained using ten-fold cross-validation. Once training was completed, the algorithm segmented a separate subset of patients. Comparing the segmentations, we demonstrated an average Dice Similarity Coefficient (DSC) of 0.70 between the algorithm and experts. In contrast, an average DSC of 0.61 was observed between the experts. In summary, we showed that the trained algorithm achieved a comparable average DSC at PE segmentation. This represents a promising step toward developing a computational tool for accurately augmenting PE diagnosis and treatment.
Familial bilateral macronodular adrenal hyperplasia due to a new ARMC 5 germline mutation. Clinical status and possible association with other neoplasms.
Authors: Piñar-Gutiérrez Ana , Mangas-Cruz Miguel Ángel , de Lara-Rodríguez Irene , Remón-Ruiz Pablo J. , Can-Sánchez Diego Del , Romero Maria del Castillo Tous , Pumar-López Alfonso
Published: February 2023

Mutations in the ARMC5 gene (armadillo repeat containing 5, OMIM 615549), a putative tumor suppression gene, have recently been identified as a common cause of sporadic and familial bilateral macronodular adrenal hyperplasia (HAMB). HAMB in familial cases is believed to be determined by two mutations, one germinal and the other somatic, as pointed out by the theory of the 2 hits. We present an affected family with 11 members carrying a new mutation of the ARMC5 gene (NM_001288767.1): c.2162T > C p. (Leu721Pro). Two of the carrier patients developed clinical Cushing Syndrome (CS), two possible autonomous cortisol secretion (ACS) and 1 presented with autonomous cortisol secretion (ACS). Four patients suffered from malignant neoplasms. Three of them died from these tumors.
When does Economic Freedom promote Equitable Social Development?
Authors: Merkel Almuth Dorothea , Marktanner Marcus
Published: February 2023

Why do some countries successfully combine economic freedom with equitable social development while others do not? We focus on the sectors of health, education, and social safety as drivers of economic freedom with equitable social development. To capture the latter, we create an index of economic freedom and Gini. Yet, identifying the exact role of government in our focus areas is difficult. Necessary data is either not available or comparable. We therefore suggest focusing on revealed relative policy strengths. This approach rests on the assumption that higher per capita incomes, all else equal, allow for better public health, greater human capital, and improved social safety. When two countries have the same income per capita, but one country performs better in any of our three focus sectors, then, we conclude, the better performing country must have a revealed relative policy strength in that sector. Our findings suggest that countries with greater revealed relative policy strengths in public health, social safety, and human capital are more effective in combining market freedom with equitable social development. In fact, we find that it is the revealed relative policy strengths that drive economic freedom with equitable social development, not the other way around.
JEL Classification:
D63 Equity, Justice, Inequality, and Other Normative Criteria and Measurement
I14 Health and Inequality
I24 Education and Inequality
O15 Human Resources • Human Development • Income Distribution • Migration
Partner Relationships, Hopelessness, and Health Status Strongly Predict Maternal Well-Being During the COVID-19 Pandemic: A Machine Learning Approach
Authors: Ooba Hikaru , Maki Jota , Tabuchi Takahiro , Masuyama Hisashi
Published: February 2023

No recent studies have explicitly focused on predicting the well-being of pregnant women during the novel coronavirus disease (COVID-19) pandemic. This study used data from an extensive online survey in Japan to examine predictors of the subjective well-being of pregnant women during the COVID-19 pandemic. We developed and validated a machine learning model using data from 400 pregnant women obtained in 2020 to identify three factors that predict subjective well-being. The results confirmed that the model could predict pregnant women's subjective well-being with 84% accuracy. The variables that contributed significantly to this prediction were "partner help," "hopelessness," and "health status." The machine learning model was built again using these three factors, trained and validated using data from 400 pregnant women in 2020, and predicted using data from 1,791 pregnant women in 2021, with an accuracy of 88%. These were also significant risk factors for subjective well-being in regression analysis adjusted for maternal age, region, parity, education level, and presence of mental illness. This model would help identify pregnant women with low subjective well-being during the COVID-19 pandemic, and appropriate interventions can then be initiated.
Meaningful subnational reporting on the SDGs: the case of mountain biodiversity protection
Authors: Ly Amina , Geschke Jonas , Snethlage Mark , Stauffer Kerrie , Nussbaumer Jasmine , Schweizer Dominic , Diffenbaugh Noah , Fischer Markus , Urbach Davnah
Published: February 2023

Indicators of biodiversity protection at the national level are used to assess progress towards global goals but provide little information at conservation-relevant scales. We provide SDG indicator 15.4.1 on mountain biodiversity protection for individual mountain ranges and further perform an area-based calculation compatible with the Kunming-Montreal Global Biodiversity Framework. We enable the identification of mountain areas in need of conservation and discuss differences between area- and official site-based indicator values.
Heterofission mechanism for pure organic room temperature phosphorescence
Authors: Sun Qi , Ren Jiajun , Peng Qian , Shuai Zhigang
Published: February 2023

Room temperature phosphorescence (RTP) from pure organic materials in crystalline or film phase has attracted great attentions recently. More and more experimental evidences pointed out that RTP is originated from isomeric dopant, instead of pure compound. The underlying mechanism and molecular design principle are unclear till now. Herein, using quantum chemistry method to compute the excited state structure and optical emission spectra coupled with quantum dynamics simulation, we propose the "heterofission mechanism" for RTP, namely, a singlet excited state is split into two triplets, one stays in the host and another goes to guest (dopant) molecule, satisfying Ehost (S1) ≈ Ehost (T1) + Eguest (T1). Five groups of RTP host and the corresponding dopant guest are taken as example. We find that all the dopants possess low triplet excited state (T1, 1.49-1.74 eV), satisfying the energy condition for heterofission process. The calculated emission spectra from these two triplets overlap well with the experimentally measured broad phosphorescent spectra. The calculated heterofission rate are expected to be at the picosecond timescale. Based on such mechanism, we are able to make prediction for potential host and guest candidates to enrich the family of pure organic RTP.