bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and efficacy of percutaneous microwave ablation for post-procedural haemostasis: a bi-central retrospective study focusing on safety and efficacy
Authors: Jiang Tian’an , Kelekis Alexis , Zhao Qiyu , Mazioti Argyro , Liu Jia , Kelekis Nikolaos , Tian Guo , Filippiadis Dimitrios
Published: December 2019

Objective:

To review safety and efficacy of percutaneous microwave ablation (MWA) for post-procedural haemostasis.

Methods:

Institutional databases retrospective research identified 10 cases of iatrogenic bleeding who underwent percutaneous MWA for post-procedural haemostasis. Ultrasound examination with Doppler and contrast enhancement identified a source of active bleeding prior to ablation; additionally they were used as guiding modality for antenna insertion whilst, post-ablation, assessed the lack of active extravasation. Target locations included liver intercostal space spleen and thyroid gland. Technical success was defined as positioning of the antenna on the desired location. Treatment end point was considered the disappearance of active extravasation in both Doppler imaging and contrast-enhanced ultrasound.

Results:

Technical success (i.e. positioning of the antenna on the desired location) was achieved in all cases. No complications were noted. All patients post MWA remained haemodynamically stable with no need for transfusion and were discharged from the hospital the next morning. Imaging and clinical follow-up in all patients before exiting the hospital did not depict any sign of active extravasation or bleeding.

Conclusion:

Our limited experience reports preliminary data showing that MWA could be added in the armamentarium of percutaneous therapies for iatrogenic bleeding. More prospective studies with larger patient samples are necessary for verification of this technique as well as for drawing broader conclusions in order to evaluate the place of percutaneous ablation in the treatment algorithm of haemorrhage.

Advances in knowledge:

Percutaneous ablation might have a role in haemostasis in well-selected cases
Infrared thermography assessment of patients with temporomandibular disorders
Authors: Barbosa JS , Amorim AMAM , Arruda MJALLA , Medeiros GBS , Freitas APLF , Vieira LEM , Melo DP , Bento PM
Published: December 2019

Objectives:

To assess patients with and without temporomandibular disorders (TMD) infrared thermography according to the differences in thermal radiance using quantitative sensitivity and specificity tests; and to evaluate the thermal asymmetry and the correlation of the thermal intensity with the intensity of pain upon palpation.

Methods:

This cross-sectional study performed a quantitative evaluation of clinical and thermographic examinations. The volunteers were evaluated for the presence of TMD using RDC/TMD (Diagnostic Research Criteria for Temporomandibular Disorders), and were divided into two groups: TMD group (n = 45); control group (n = 41), composed of volunteers without TMD, according to the Fonseca Anamnestic Index. The images were assessed for selected regions of interest for the masseter, anterior temporal and TMJ muscles. The mean values ​​of the areas of both groups were compared under the receiver operating characteristic curve. Spearman correlation analysis (non-parametric data) between pain level and mean temperature, by region, and the Pearson's χ2 test was used to verify the association between the presence of temperature and pain asymmetry. The level of significance was set at p < 0.05.

Results:

Both Groups, with and without TMD, presented with absolute and non-dimensional mean temperature without statistical differences (p>0.05). When correlating temperature with intensity of pain upon palpation, a negative correlation was observed for the masseter muscle.

Conclusion:

Infrared Thermography resulted in low area under the curve, making it difficult to differentiate TMD via thermographic analysis. The intensity of pain upon palpation in patients with TMD may be accompanied by a decrease in local temperature.
Determining the lx and estimating the force of mortality for children under five in Bangladesh
Authors: Islam Md. Rafiqul , Rana Md. Sohel , Hossain Md. Mosharaf , Rosy Sarkar Aziza Sultana , Mat Min Ruhani
Published: December 2019

Background: Under-five mortality is a health indicator in population health and the health sciences. Force of death is a more accurate measure of mortality than others, which indicates the situation of mortality when time tends to zero. The purpose of this research is to construct a simulation for lx (the number of people living at exact age x) for under-five mortality in Bangladesh as a whole, and separately for rural and urban areas, and then estimating the mortality rate in regard to these matched models.

Methods: Secondary data were collected from Bangladesh Demographic and Health Survey 2007. A polynomial model was selected to match the lx values. To prove the accuracy of the model, the rule of cross-validity was applied.

Results: It has been shown that fourth degree polynomial models can be adjusted to lx values ​​with explanation of more than 94% variation. It was noted that the mortality rate shows a rapidly decreasing pattern for people aged 0-20 months, a monotonically increasing pattern for those aged 20-53.5 months and then it begins to decrease. It is found that the mortality rate in rural areas is higher than in urban areas of all ages.

Conclusions: It has been shown that the mortality rate in rural areas is higher than for urban areas of all ages, except for those aged 53.5 months. The health situation should therefore be improved to reduce mortality in rural Bangladesh.
Case Report: Occupational therapy in a patient with an overgrowth syndrome that restricts movement
Authors: Coppeta Luca , Gentili Sandro , Papa Francesca , De Zordo Ludovico Maria , Mugnaini Stefano , Pietroiusti Antonio
Published: December 2019

Background: Overgrowth syndromes are a heterogeneous group of conditions characterized by excessive body growth - localized or generalized - commonly associated with various malformities and an increased oncological risk.

Case report: Here we present the case of a 57-year old man, employed in an office, who suffers from an asymmetric overgrowth of the lower limbs. Currently the patient presents malformations of the lower left arm (hip, knee and ankle), evident on the articular and periarticular level, where there are diffuse exostoses. This case discusses the main occupational concerns relating to the patient’s workspace at a high floor level that could create critical issues in the event of an emergency exodus. Given the impossibility of placing the patient in heavy manual activities, employment is limited to office activities. Adjustments were carried out at the patient’s workstation, and thus the patient has been recognized as fit to work. Increased frequency of breaks were prescribed in order to allow the physiological alternation of postures.

Conclusions: In cases of overgrowth syndromes, the exact identification of the limitations presented by the patient and observations about ambulatory functions must be carefully evaluated in order to modulate the work environment.
Diagnostic accuracy and clinical impact of natriuretic peptide screening for the detection of heart failure in the community: a protocol for systematic review and meta-analysis
Authors: Goyder C. R. , Roalfe A. K. , Jones N. R. , Taylor K. S. , Plumptre C. D. , Fanshawe T. R. , Hobbs F. D. R. , Taylor C. J.
Published: December 2019

Introduction: Patients diagnosed with heart failure in primary care have a better prognosis than those diagnosed in hospital. However, most cases are missed in the community. Recent attention has focussed on the potential of early detection through screening. Natriuretic peptides (NPs) are tested by GPs and used to rule out heart failure in patients presenting with symptoms. Evidence is now emerging that they may also have a role in screening but their accuracy in this context and the associated optimal thresholds, have not been established. The impact that NP screening would have on patients and health care systems also remains unclear.

Methods: We aim to undertake a systematic search of the following sources: Ovid Medline, Embase, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials. Screening, data extraction and critical appraisal will be carried out independently and in duplicate by two reviewers. We will include studies based in the community with >100 participants that recruited a screened population. We will not add a study design filter and there will be no language restriction. The primary outcome will be the sensitivity and the specificity of NP screening and optimal thresholds for screening will be explored. Outcomes of interest for the impact analysis will include mortality, hospital admissions and cost effectiveness. This protocol has been developed in accordance with guidelines from the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P).

Discussion: This systematic review will identify how accurately NP screen for heart failure in the community and explore where NP screening thresholds should be set. It also aims to summarise the clinical impact of this strategy. Together, these results should inform future interventions that may provide an alternative pathway to facilitate improved detection of heart failure in the community.

Registration: PROSPERO CRD42018087498; registered on 11 May 2018.
Evolutionary analysis of the most polymorphic gene family in falciparum malaria
Authors: Otto Thomas D. , Assefa Sammy A. , Böhme Ulrike , Sanders Mandy J. , Kwiatkowski Dominic P. ,   Pf3k consortium, Berriman Matt , Newbold Chris
Published: December 2019

The var gene family of the human malaria parasite Plasmodium falciparum encode proteins that are crucial determinants of both pathogenesis and immune evasion and are highly polymorphic. Here we have assembled nearly complete var gene repertoires from 2398 field isolates and analysed a normalised set of 714 from across 12 countries. This therefore represents the first large scale attempt to catalogue the worldwide distribution of var gene sequences

We confirm the extreme polymorphism of this gene family but also demonstrate an unexpected level of sequence sharing both within and between continents. We show that this is likely due to both the remnants of selective sweeps as well as a worrying degree of recent gene flow across continents with implications for the spread of drug resistance. We also address the evolution of the var repertoire with respect to the ancestral genes within the Laverania and show that diversity generated by recombination is concentrated in a number of hotspots. An analysis of the subdomain structure indicates that some existing definitions may need to be revised

From the analysis of this data, we can now understand the way in which the family has evolved and how the diversity is continuously being generated. Finally, we demonstrate that because the genes are distributed across the genome, sequence sharing between genotypes acts as a useful population genetic marker.
Social Networks, Funding, and Regional Advantages in Technology Entrepreneurship: An Empirical Analysis
Authors: Butler John Sibley , Garg Rajiv , Stephens Bryan
Published: December 2019

With the increased penetration of digital technologies into entrepreneurship, the traditional need for proximity to specific locations or large amounts of funding for infrastructure development has diminished. Instead, digital entrepreneurs now pursue locations that provide more opportunities for funding (rounds) and greater social network support. Analyzing data for entrepreneurial ventures that were successful in receiving some external funding, we found that the number of funding rounds per year plays a significant and positive role in influencing start-up creation in that location—interestingly, amount of funding does not. Furthermore, local social network density creates stickiness to that location, thus negatively influencing entrepreneurs' willingness to relocate. If entrepreneurs do relocate to create a start-up after a short delay, larger social network density (in a new location) positively affects start-up creation decision in that location. Additionally, we find that midcareer individuals (such as millennials) are more likely than early-career or late-career stage individuals to create a successful technology start-up. Also, entrepreneurs are less likely to relocate for an Internet-based start-up but are likely to move if they have larger social network density in the new location. This research enhances our understanding of the factors that influence decisions to launch a start-up in a particular location and provides policy implications for creating a rich entrepreneurial ecosystem in a city.
Removing barriers to SEND provision
Authors: Thomas Elizabeth
Published: December 2019

Well trained staff are a setting's most precious resource when it comes to overcoming barriers to effective SEND provision. Here Elizabeth Thomas provides different perspectives on how to achieve the best individual support for a child and flags up the latest qualifications and training opportunities that are helping to create a new generation of highly skilled SENCOs.
A new species of the genus Xiomara Gauld, 1997 (Hymenoptera, Ichneumonidae, Ctenopelmatinae) from Peru

Authors: RESHCHIKOV ALEXEY
Published: December 2019

The endemic Neotropical genus Xiomara Gauld, 1997 was described as monotypic. A new species of Xiomara from Peru is described and illustrated: X. mabelae Reshchikov sp. nov. An identification key to known species is provided.Key words: Amazonia, Junin, Perilissini, Neotropical, tropical rainforest, endemic species
Instruments for assessing organisational capacity for use of evidence in health sector policy making: a systematic scoping review
Authors: Asgharzadeh Asra , Shabaninejad Hosein , Aryankhesal Aidin , Majdzadeh Reza
Published: December 2019

Background

Assessing individual and organisational capacity for evidence use is essential for developing evidence-based strategies.

Aims and objectives

This study aimed to assess the psychometric and practical properties of existing tools to assess the capacity to use evidence at the individual and organisational levels of health policy and identify the best instruments.

Methods

A systematic review of the databases of ISI Web of Science, Embase, Scopus, and PubMed was conducted up to 6 June 2018. Search engines, websites of key organisations, and the reference lists of selected articles were also used to find relevant studies. The search strategy for each database was written individually. Psychometric properties were assessed using the Standards for Educational and Psychological Testing (SEPT) and pragmatic properties were assessed using the protocol proposed by Lewis et al (2018). Simple statistics were used to describe the psychometric and pragmatic properties of the identified instruments.

Results

Overall, 16 instruments were identified. SEER had the highest validity score. Reliability was estimated for 38% of the instruments. Responsiveness was assessed in only 19% of the studies. The results showed that internal consistency was reported for 40% of the articles using statistical analysis. Pragmatic properties of the studied instruments were verified; 75% usefulness, 56% actionability, 50% sensitive to change and 56% user-friendly, 19% compatible, 38% feasibility.

Discussion and conclusions

There are few instruments with strong psychometric evidence, and without high-quality instruments, it would be difficult to determine the factors that affect implementation. Therefore, special attention is needed for the systematic development of instruments and their reporting standards.
Study of burst-mode adaptive equalization for >25G PON applications [Invited]
Authors: Coudyzer Gertjan , Ossieur Peter , Breyne Laurens , La Porta Antonio , Paredes Stephan , Bauwelinck Johan , Yin Xin
Published: December 2019

In anticipation of emerging applications such as business services, 5G, and the Internet of Things, research and standardization are working together towards next-generation 25/50 Gbit/s passive optical network access networks. However, the increase in single-channel line rate is limited by the distortion introduced by the low-cost device’s bandwidth limit or the chromatic dispersion in the fiber. Burst-mode electronic distortion/dispersion compensation can be used to mitigate these effects, but requires a burst-mode equalizer (BMEQ) for upstream traffic and introduces many challenges. In this invited paper, the feasibility of single-channel, directly modulated upstream 25 Gbit/s non-return-to-zero transmission is investigated in more detail. By using a linear burst-mode transimpedance amplifier together with an offline BMEQ, specific BMEQ penalties and trade-offs such as limited training time and burst-to-burst phase variation are considered.
PON transceiver technologies for ≥50  Gbits/s per λ: Alamouti coding and heterodyne detection [Invited]
Authors: Erkılınç M. S. , Emmerich R. , Habel K. , Jungnickel V. , Schmidt-Langhorst C. , Schubert C. , Freund R.
Published: December 2019

There has been an ongoing quest for transceiver technologies to be employed in next-generation passive optical networks (PONs) beyond 25G due to the growing number of subscribers and connected devices per subscriber and the ever-increasing bandwidth demand per device/application. Given the cost and loss/power budget requirements, the candidates seem to be digital signal processing (DSP)-aided intensity-modulation/direct detection (IM-DD) and low-complexity coherent transceivers. Here, we experimentally demonstrate a 100G coherent-lite PON using a novel transceiver DSP chain that utilizes a frequency-diverse dual-polarization RF pilot tone pair. The proposed scheme enables the implementation of Alamouti coding for single-carrier signaling, which is used in conjunction with heterodyne detection, achieving a significant complexity reduction in a coherent optical network unit (ONU) receiver. It consists of a single balanced photodiode followed by an analog-to-digital converter, offering comparable optical complexity to its DD counterpart, at the expense of DSP complexity in the ONU. The performance of a transceiver architecture facilitated by the proposed DSP was assessed in both back-to-back operation and up to 80 km standard single-mode fiber transmission using an

∼
1

MHz

linewidth distributed feedback laser as an ONU laser. At the hard-decision forward error correction (7% overhead) threshold, assumed to be

4
×

10

−
3

, a receiver sensitivity of

−

29.6

dBm

and a loss budget of 36.6 dB at a launch power of 7 dBm are achieved.
Interiorización de la educación superior pública: puntos de atención, ajustes y autonomía universitaria
Authors: Vargas Hustana Maria
Published: December 2019

Después de ocho años de ejecución del Programa de Ampliación de las universidades federales, podemos identificar varias posibilidades y dificultades en el proceso de interiorización. Este documento destaca los elementos clave de este proceso, como la oferta y la cobertura de vacantes, las tasas de conclusión resultantes y la calidad de la educación ofrecida, teniendo en cuenta la oferta dicotómica en la sede y en el interior. Tomamos el caso de la Universidad Federal Fluminense (UFF), una de las más interioriorizadas del país para discutir la efectividad de la autonomía universitaria a los desafíos del proceso, planteando preguntas para su continuidad.
Effects of dichloromethane Sarcophyton spp. extract on the lipopolysaccharide-induced expression of nuclear factor-kappa B and inducible nitric oxide synthase in mice
Authors: Riyadi Putut Har , Wahyudi Didik , Tanod Wendy Alexander
Published: December 2019

Background and Aim: The soft coral genus Sarcophyton is a source of cembraneterpen. Sarcophyton is reported to have anti-inflammatory properties, with the ability to reduce the expression of inducible nitric oxide synthase (iNOS) and inhibit nuclear factor-kappa B (NF-κB) activation. This study aimed to investigate the efficacy of dichloromethane (DCM) extracts of soft coral Sarcophyton spp. to inhibit the expression of NF-κB and iNOS induced by lipopolysaccharide (LPS). Materials and Methods: Crude extracts of Sarcophyton spp. were macerated with DCM (1:3 v/v) for 24 h. Thirty-six Balb/c mice were divided into six treatment groups, namely, normal control (without LPS induction), negative control (LPS induction 4 mg/mL), comparative control (LPS+Dexamethasone 6 mg/kg), and 3 concentration groups extract (LPS+50, 125, and 250 mg/kg). The expression of NF-κB and iNOS was measured in each treatment group. Results: Flow cytometry analysis showed that the relative number of NF-κB+ cells increased (18.38±1.24%) in LPS-induced mice compared with normal mice (13.24±1.15%). The Sarcophyton spp. DCM extracts decreased the relative number of NF-κB+ cells (125 mg/kg: 13.96±0.84%). Immunohistochemical analysis with ImmunoMembrane showed that LPS induction in mice increased iNOS expression when compared to normal mice. The Sarcophyton spp. DCM extracts reduced iNOS expression (especially at 125 mg/kg). Conclusion: DCM extracts of Sarcophyton spp. inhibited the activation of NF-κB, resulting in suppressed iNOS expression, which directly inhibits NO production.
P006 Health-Related Quality of Life in Brazilian Adolescents and Young Adults (AYA) With Inflammatory Bowel Disease
Authors: Oba Jane , Deboni Mariana , Toma Ricardo , Sobrado Carlos , Borba Marcelo , Azevedo Matheus , Carlos Alexandre , Queiroz Natália , Damião Adérson , Silva Clóvis Artur
Published: December 2019

BACKGROUND:

IBD comprises Crohn ́s disease (CD) and ulcerative colitis (UC), both are characterized by unpredictable exacerbations and remissions. The incidence is highest in adolescence and early adulthood and alike other chronic disease have a considerable impact upon patients' HRQoL. Few studies assessing HRQoL have been performed in AYA populations. Our objectives were to assess the health related quality of life (HRQoL) in adolescents and young adults (AYA) patients with inflammatory bowel disease (IBD) and analyze the disease factors that could influence it.

METHODS:

59 AYA IBD patients (13-25y) at two gastroenterology units of tertiary hospitals were evaluated and compared to 60 AYA healthy controls (13-25y). 59 AYA IBD patients completed the Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), Short Form Health Survey (SF-36) questionnaires and Pain Visual Scale, according to age. After we compared HRQoL between Crohn’s disease (CD) vs. UC (ulcerative colitis) in AYA population. The demographic data, extra-intestinal manifestation, overlap syndromes, disease active status, treatment and outcomes were also evaluated. All participants and the adolescents' legal guardian written informed consent form.

RESULTS:

PedsQL4.0 domain “school/work” and SF-36 domain “general health perception” was reduced in IBD AYA patients compared with healthy controls (p < 0.05). In addition, significantly lower score “health change” in SF-36 in comparison with healthy determined perceived differences in state of health over the past year. No difference in other domains and pain scale was observed between CD and UC AYA patients. Disease activity as well extra intestinal manifestations, overlap syndromes, treatments and outcomes did not influence the HRQoL of the AYA patients. Autoimmune sclerosing cholangitis and the use of prednisone were significantly higher among UC patients, whereas previous gut surgery was higher between CD patients. However, these disease factors did not significantly influence the HRQoL between CD vs UC. Mann-Whitney test and Fisher's test were used to compare continuous variables and comparison between groups, p-values were set at 5% (p < 0.05).

CONCLUSION(S):

HRQoL was significantly lower for AYA with IBD relative to healthy controls. These results highlight areas to focus clinical attention in adolescents and young adult patients with IBD for assessment and future interventions.
P029 Patient Perception and Clinical Impact of Direct-to-Consumer Advertising in Inflammatory Bowel Disease
Authors: Gu Phillip , Yang Edward , Chittajallu Punya , McNeill Cathy , Singal Amit , Kwon John , Ahmed Tasneem
Published: December 2019

BACKGROUND:

Direct-to-consumer drug advertising is a controversial marketing strategy that can potentially empower patients and/or negatively impact clinical practice and the patient-provider relationship. With an increasing number of available therapies for inflammatory bowel disease (IBD), little is known about patients’ attitudes regarding IBD-related direct-to-consumer advertising (IBD-DTCA) and its impact on treatment decisions in clinical practice. We aim to characterize patient perception of IBD-DTCA and its impact on clinical decision making.

METHODS:

We administered a 58-item, mailed questionnaire to patients with IBD receiving Gastroenterology subspecialty care at a large academic health system. The survey assessed patient awareness and perception of IBD-DTCA and its effect on IBD treatment discussions and decisions. We used bivariate analysis to evaluate patient-level factors associated with awareness and favorable perception of IBD-DTCA.

RESULTS:

We achieved a response rate of 15.2% (n = 226 of 1486). Most patients (93.3%) reported awareness of IBD-DTCA, with adalimumab receiving the most exposure. A majority of respondents reported IBD-DTCA made them more aware of treatments they otherwise would not know about (53.6%), provided information in a balanced manner (63.5%), and taught them about new potential risks and side effects (64.5%). Patients without a college degree and those with a household income less than $75k per year perceived IBD-DTCA significantly more favorably. A minority of aware respondents reported IBD-DTCA made them less confident in their provider’s judgement (12.3%) and that a treatment option was being withheld (6.6%). Finally, IBD-DTCA rarely changed IBD management, with only 7.6% of respondents having a discussion with their provider about the advertised drug and only two respondents (0.9%) being initiated on the advertised drug.

CONCLUSION(S):

IBD patients were aware of IBD-DTCA and perceived it favorably; however, IBD-DTCA rarely led to patient-provider discussions or changes in treatment regimen.
P056 Methodology and Initial Results From TOUR (Tofacitinib Response in Ulcerative Colitis): A Real World Prospective Multicenter Study
Authors: Long Millie , Abdalla Maisa , McCabe Robert , Fischer Monika , Cohen Benjamin , Afzali Anita , Polyak Steven , Hanson John , Herfarth Hans
Published: December 2019

BACKGROUND:

Tofacitinib is a janus kinase (JAK) inhibitor approved for use in ulcerative colitis (UC) in 2018. Prospective real-world data on tofacitinib use in UC patients are limited. We aimed to develop a unique electronic system to obtain patient reported outcomes (PROs) from patients initiating tofacitinib. We aimed to measure response to therapy on days 1-14, anxiety, depression and social satisfaction.

METHODS:

An initial sample of 23 patients were recruited from 8 academic and community gastroenterology practices. Complete demographic information, disease and medication histories were obtained. Patients completed PRO surveys on days 1-14 after initiation of tofacitinib via a unique electronic self-report system. Outcome data included the simple clinical colitis activity index (SCCAI), and PRO measurement information system (PROMIS) measures of depression, anxiety and social satisfaction. A score of ≤2 on SCCAI was considered to be remission; a score of <4 with a decrease by > 1.5 points was considered to be response. PROMIS measures were calibrated using a T score metric with the mean of the standard US population equal to 50, standard deviation (SD) of 10. A higher PROMIS score equates to more of the measure (higher scores worse for depression, anxiety and higher scores better for social satisfaction).

RESULTS:

A total of 23/23 (100%) completed electronic PRO data daily in the first 14 days after initiation of tofacitinib. Mean age of the population was 40.7 (SD 18.1), 56.5% were male, mean disease duration was 11.3 years and 73.9% were on concomitant steroids. Mean disease activity at baseline (n = 23) was active (SCCAI of 4.0), with reductions in mean daily disease activity to a nadir of SCCAI 2.2 on day 14. Among patients initiating tofacitinib without concomitant corticosteroid use (n = 6), similar early reductions in SCCAI were seen (mean SCCAI 4.0 at baseline, reduced to 1.8 by day 4). Improvements in all PROMIS measures (anxiety, depression, social satisfaction) were seen in the population by day 7. A total of 8/12 (66.7%) with active disease at baseline met criteria for response at day 14.

CONCLUSION(S):

Real time electronic PRO data capture directly from UC patients is feasible. This ongoing prospective multi-center real-world cohort demonstrated an excellent patient adherence to the online platform in the first 14 days. Initial data suggest a rapid response to tofacitinib in this sample, with improvements in disease activity, depression, anxiety and social satisfaction. Continued enrollment and long-term follow-up data from this cohort will enhance our knowledge of tofacitinib use in real world UC populations.
P079 Real-World Prescribing Patterns of Certolizumab in the Treatment of Crohn’s Disease
Authors: Ritter Timothy , Fourment Chris , Kuten Samantha , Van Anglen Lucinda
Published: December 2019

BACKGROUND:

Certolizumab (CZP) is a pegylated anti-tumor necrosis factor (TNF) agent approved for the treatment of moderate-to-severe Crohn’s disease (CD). CZP therapy has proven effective and well-tolerated for biologic-naïve patients, as well as anti-TNF-experienced patients with secondary non-response or intolerance. CZP is also the preferred anti-TNF during pregnancy. We sought to describe real-world prescribing patterns of CZP in the treatment of CD.

METHODS:

We performed a retrospective cohort study of CD patients treated with CZP at a large multicenter gastroenterology private practice since drug approval in 2014. Data collection included demographics, diagnosis, treatment history, and reason for CZP use. CZP use was classified as one of the following: first-line anti-TNF, prior anti-TNF non-response or intolerance, payor requirements, and/or pregnancy considerations.

RESULTS:

A total of 59 patients receiving CZP for the treatment of CD were identified. Mean age was 48 ± 16.1 years and 42 (71%) were female. Median CZP treatment duration was 26 [IQR 9-50] months. Forty-four (78%) patients had private insurance, 12 (20%) were enrolled in Medicare or Medicaid, and 1 was uninsured. Nine (15%) patients were bio-naive. Of the 50 (85%) biologic-experienced patients, 22 were previously treated with 1 agent, 23 received 2 previous agents, and 5 patients received 3 or more previous agents. Reasons for CZP use were as follows: prior anti-TNF non-response or intolerance in 39 (66%), pregnancy considerations in 8 (14%), payor requirements or cost considerations in 6 (10%), first-line anti-TNF in 4 (7%), and other reasons in 2 (3%). To date, 26 (44%) patients remain on CZP with a median treatment duration of 48 [IQR 31-59] months.

CONCLUSION(S):

We described real-world utilization of CZP. In our cohort, CZP was most commonly prescribed to biologic-experienced patients with prior anti-TNF non-response or intolerance.
P102 Mortality in Mexican Population With Inflammatory Bowel Disease Treated in a Tertiary Care Hospital in Mexico City
Authors: Trujillo de la Fuente Korely , López Goméz Jesús , Cortes Espinosa Tomas , Ramos Gómez Mayra , Aleman Abitia Dassaev , Navarro Gerrard Christian , Ramirez del Pilar Rodolfo , Aguilar Hernandez Jhonatan , Klimek Albarrán Gabriel
Published: December 2019

BACKGROUND:

Inflammatory bowel disease (IBD) is a chronic idiopathic, inflammatory process of the gastrointestinal tract without a known cause. IBD is divided into Crohn’s disease (CD) and Ulcerative Colitis (UC). In Latin-American IBD presents with low frequency. Due to the severe deterioration of the quality of life, risk of developing malignancies and mortality they are considered of great clinical importance. Since the management of the disease has varied in recent years, it is necessary to know the magnitude of the inflammatory bowel disease and its associated mortality.

METHODS:

A historical cohort of patients from the IBD clinic in the Centro Médico Nacional 20 de Noviembre ISSSTE was analysed in the time frame corresponding from 20 years. All patients met diagnostic criterion for IBD. Study: descriptive, retrospective and transversal. Relative and central frequency averages were used to obtain percentages, averages and standard deviation. Chi square test was used for qualitative variables and Student's T-test was used for continuous numerical quantitative variables. Risk calculation (OR) was made from cross tables to show the prediction of mortality.

RESULTS:

A total of 103 patients with IBD were included, 72 patients had UC of which 52.8% were female with a mean age of 50 ± 15.8 years and 31 patients had Crohn of which 58.1% were female with a mean age of 52.3 ± 16.6 years. In the UC group 48.6% were in treatment with biological agents and 51.4% were on immunosuppressants and other treatments (mesalazine and steroids). In the CD group 77.4% were treated with biological agents and 22.6% were on immunosuppressants and other treatments (mesalazine and steroids). Surgical treatment was required in 22.3% of the patients. A total mortality of 9.7% was reported and predominated in UC (50% due to post-surgical complications, 40% secondary to sepsis, 10% metastasis). In the risk calculation (OR) performed for the prediction of mortality, no significant difference was found in terms of type of disease (P = 0.34, OR 1.63, 95% CI 0.42-6.23), gender (P = 0.51, OR 1.21, 95% CI 0.32-4.47), or biological treatment (P = 0.73, OR 0.96, 95% CI 0.93-0.96). In patients undergoing surgical treatment, they obtained a statistically significant result with P = 0.008, OR 6.70, 95% IC 1.7-26.3.

CONCLUSION(S):

The mortality rate in patients with IBD in this study was of 9.7%. The group where more deaths were reported was in the UC group. Statistical significance was found when analysing surgical procedure as a predictor of mortality. Due to the small sample size, a prospective randomized study to confirm these findings is needed. This work has no conflict of interest.
P103 Ileocecal Obstruction Secondary to Campylobacter Jejuni Ileitis
Authors: Diem Vu T.N. , Watkins Ryan , Hanada Yuri , Schupack Daniel , Oblizajek Nicholas , Chua Heidi , Papadakis Konstantinos
Published: December 2019

BACKGROUND:

Acute ileitis is most classically associated with inflammatory bowel disease. However, several infections can also cause inflammation or obstruction of the terminal ileum. Clinical presentation is usually acute and characterized by abdominal pain of the right abdomen.

CASE REPORT:

We report the case of a healthy 24 year-old man who presented with a two month history of right lower quadrant pain, nausea and emesis after returning from a trip to South Africa. Over the subsequent two months, he had continued symptoms and an ileocecal obstruction was demonstrated both on cross-sectional imaging and on colonoscopy. A stool pathogen panel was positive for Campylobacter jejuni, and he completed an empiric three-day course of azithromycin. Endoscopic biopsies were negative for histologic features of inflammatory bowel disease. After three hospitalizations for recurrent obstruction, an ileocecal resection was performed. The resection specimen revealed marked eosinophilia within the muscularis propria and submucosal fibrosis. The patient made an uneventful recovery following his surgery.

CONCLUSION:

Although inflammatory bowel disease should be excluded during the workup of terminal ileitis, this case illustrates the importance of including infections and post-infectious sequelae in the differential, especially in otherwise healthy patients with recent travel history.
Use of teriparatide in treatment of severe osteoporosis in geriatric practice: a clinical case review
Authors: Dudinskaya Ekaterina N. , Tkacheva Olga N. , Machekhina Liubov V. , Ostapenko Valentina S. , Brailova Natalya V.
Published: December 2019

Elderly and senile people are characterized by a high prevalence of osteoporosis, which, in turn, increases the risk of fractures, including the repeated ones. Fractures in osteoporosis are an extremely unfavorable complication of the disease, leading to catastrophic consequences in old age. The prevalence of osteoporotic fractures progressively increases with age. At present, the cumulative frequency of hip fractures in women over 80 is about 30%. The proportion of vertebral fractures in women older than 80 years is up to 40% of all vertebral osteoporotic fractures. Despite the tremendous successes achieved in the diagnosis and treatment of osteoporosis, the disease itself and related fractures remain a serious medical, economic and social problem. Prevention of recurrent fractures in geriatric patients is a system of preventive, rehabilitative and therapeutic measures aimed at reducing the risk of falls, choosing an effective therapy, and reducing the risk of recurring fractures. A serious problem in the treatment of osteoporosis in older people is the inefficiency of the antiresorptive therapy due to an age-related decrease in bone formation. There are frequent cases of a continuing decrease in bone density, the occurrence of repeated fractures during ongoing therapy of osteoporosis. Often the therapy of choice in this case is bone-anabolic therapy with teriparatide, which allows one to achieve good results in the accumulation of bone mineral density. In this article, we will present the clinical case of an elderly patient with severe osteoporosis, in which teriparatide became the drug of choice.
Chemical profile and allelopathic potential of Anacardium humile St. Hill. (cajuzinho-do-cerrado) leaf aqueous extract in the seed germination and seedling growth of lettuce, tomato and sicklepod
Authors: Pereira Kelly Cristina Lacerda , Matias Rosemary , Rizzi Elvia Silvia , Rosa Ana Carolina , Oliveira Ademir Kleber Morbeck de
Published: December 2019

Anacardium genus, Anacardiaceae, stands out for the presence of phenolic compounds. One of its species, investigated for its different potential uses, is Anacardium humile; however, little is known about its allelopathic effects. Therefore, the present study aimed to determine the chemical profile and evaluate the herbicide potential of your leaves in the germination of seeds and growth of seedlings of Lactuca sativa (lettuce), Lycopersicon esculentum (tomato) and Senna obtusifolia (sicklepod), both in vitro and in greenhouse. Leaves of A. humile were obtained from 20 matrices of Cerrado fragments in the municipality of Campo Grande, Mato Grosso do Sul state, Brazil. A voucher specimen was deposited at the herbarium (no. 8448). The aqueous extract was obtained from dried and crushed leaves using the extraction method of ultrasonic bath (30 min) with subsequent static maceration. After solvent evaporation, 12.78 g of extract were obtained. The chemical profile of the aqueous extract included determination of total phenolic and flavonoid contents, pH, electrical conductivity, and soluble solids concentration. For the in vitro bioassays, the extract was used at different concentrations, namely, 25, 50, 100, 150, and 200 mg mL-1. In greenhouse, the substrates were prepared using 950 g of vermiculite and 50 g of A. humile leaf powder at the following ratios: (950/50) (5%), 900/100 (10%), 800/200 (20%), and a control (100% vermiculite), under a completely randomized experimental design. Phenolic compounds and anthraquinones were predominant in the chemical profile of the extract, which presented different levels of allelopathic effect on seed germination and seedling growth of plants both in germination chamber and in greenhouse, indicating strong allelopathic activity associated with the different compounds found in the leaves. Therefore, the results showed germination and growth inhibition at different levels, indicating that the substances contained in the leaves of Anacardium humile may be a promising alternative for the control of invasive species.
Mobile emergency services: the actions of the nursing team in situations of violence
Authors: Camargo Fernanda Carolina , Garcia Luan Augusto Alves , Lucena Ana Carolina Rodrigues de , Iwamoto Helena Hemiko , Souza Regiane Máximo de , Zullo Sergio Antonio , Santos Álvaro da Silva
Published: December 2019

Objective: analyzing the profile of attention of the mobile emergency services in cases of violence and the actions of the nursing team. Methods: observational, exploratory and analytical study made from secondary records. A Correspondence Analysis was conducted to identify the associations between the actions of the nursing team and the profile of the necessity of care due to violent causes. Results: from 1800 cases, most took place during the weekend (49.2%), involving men (70.0%) and traffic accidents (76.5%). The correspondence analysis highlighted two dimensions (76.7% of explanatory contribution), resulting in three similar groups considering the nursing professional taking part in the attention, how the situation ended, period in which it occurred, and profile of the victim. Conclusion: the analysis was strategic for the systematization of data which gave support to the situational understanding of the composition of the service and for the planning of the actions of the nursing team.
Corpo na capa: representações de homens e mulheres nas revistas Men’s Health e Women’s Health
Authors: Ferreira Gisllene Rodrigues , Spannenberg Ana Cristina Menegotto , Campos Raquel  Discini de
Published: December 2019

A versão brasileira da revista Men’s Health teve sua primeira publicaçãono Brasil em maio de 2006. Em novembro de 2008, foi lançada no país a Women’s Health. Porém, ambos os impressos encerraram suas distribuições em dezembro de 2015. Franquias norte-americanas, as revistas tiveram seu conteúdo construído em função de dicas sobre como se exercitar para ter o corpo magro e definido; artigos sobre a conquista e manutenção de um determinado tipo beleza; sugestões sobre alimentação adequada, moda, comportamento e sexualidade. Os estudos da área de Comunicação Social e História Social da Imprensa indicam que a capa de uma revista é o primeiro contato do público leitor com o ethos da publicação. Diante da importância que ela assume, esta pesquisa se debruça sobre as capas dos impressos acima mencionados, tendo como referência de análise os estudos de recepção, levando em consideração que o receptor está presente no texto desde a instância de produção, enquanto uma estratégia. O artigo se propõe a discutir as estratégias de construção do leitor pelas capas de Men’s Health e Women’s Health, a partir do conceito de leitor modelo de Umberto Eco (1986), considerando operadores técnicos de análise (imagem, composição gráfica e cores) e operadores temáticos de análise (beleza, corpo, sexualidade e papéis sociais). Interessante perceber como a beleza, em épocas atrás, era medida pela “fartura” corporal que indicava saúde e também riqueza, mas, nos dias atuais, o “gordo” é tido como feio e doente (Sant”Anna 2005). Para Vigarello (2006), embelezar-se é quase “uma obrigação” da mulher, pois só assim ela mostrará sua feminilidade natural. Ele identificou este modo de ser como constitutivo das subjetividades femininas contemporâneas. Em suma, buscar o padrão ideal de corpo é uma atividade que recai com maior peso sobre o gênero feminino do que sobre o masculino. Isso porque historicamente o “valor” da mulher diante da sociedade está em fazer-se bela como parte da sua ética e identidade, enquanto que o homem não tem sua identidade construída apenas em relação aos cuidados do corpo. Ele é também valorizado pela virilidade e atividades ligadas ao trabalho. Após a realização da pesquisa, com ênfase na leitura das capas das referidas publicações, concluímos que o jornalismo produzido para o homem e para a mulher não são semelhantes, mesmo quando são analisados impressos que giram em torno de uma mesma temática: a saúde do corpo. Antigos estereótipos relacionados a uma suposta essência feminina são reforçados cotidianamente nas capas de Women’s Health, enquanto as capas de Men’s Health indicam construções mais propositivas e inovadoras.
Possibilidades e limites das tecnologias na Educação Infantil: um olhar sobre as teses e dissertações dos anos de 2006 a 2016
Authors: Nunes Hélida Cristina Brandão , França Robson Luiz de
Published: December 2019

Este artigo descreve uma pesquisa que teve o objetivo de investigar as teses e dissertações desenvolvidas nos anos de 2006 a 2016, com o propósito de analisar as possibilidades das tecnologias, os limites e sua articulação à prática pedagógica infantil. Os resultados revelaram que o computador foi o recurso mais discutido e estava relacionado aos laboratórios de informática na maioria dos estudos. As possibilidades ressaltadas foram o enriquecimento do processo de ensino-aprendizagem, crescimento do interesse, da autonomia, do trabalho colaborativo com ampliação de novas linguagens e a possibilidade do letramento digital. Contudo, os limites salientaram difi culdades de suporte técnico, problemas de conexão com a rede de Internet, de aquisição de recursos mais atuais, bem como qualifi cação profi ssional, ressaltada na maioria dos trabalhos.
The meanings of higher education, work, and transition from higher education to work
Authors: Monteiro André , Santos Paulo Jorge , Gonçalves Carlos
Published: December 2019

Num tempo de incerteza e precarização do trabalho, este estudo tenta compreender como os estudantes do ensino superior constroem significados sobre a educação superior, o trabalho, a transição da educação para o trabalho e como estes se relacionam entre si. Com uma amostra de 986 estudantes do Ensino Superior português visa-se compreender as relações e mediações das dimensões dos significados da educação superior com as dimensões dos significados da transição da educação superior para o trabalho e as dimensões dos significados do trabalho. A dimensão Afirmação Profissional é mediadora da relação entre o Desenvolvimento Pessoal e Social e a Dimensão Pessoal e Social do Trabalho. Com base na análise dos resultados algumas pistas de intervenção são apresentadas.
Conceções dos professores portugueses sobre multilinguismo e práticas educativas em salas de aula multilingues
Authors: Martins Margarida Alves , Sousa Otília , Castro São Luís , Dockrell Julie , Papadopoulos Timothy , Mifsud Charles
Published: December 2019

A Europa é uma realidade linguística diversa e heterogénea que enfrenta o desafio de educar uma população cada vez mais multicultural e multilingue. Os professores de língua(s) são atores nesta realidade, promovendo o multilinguismo e integrando a diversidade. Portugal não foge ao paradigma do multilinguismo e as escolas e professores portugueses vão-se adaptando a uma realidade que, não sendo nova, tem novos contornos. Neste artigo, analisam-se as conceções de professores portugueses sobre multilinguismo e as práticas educativas desenvolvidas em salas de aula multilingues por eles referidas. Os participantes foram 505 professores de todos os ciclos de ensino a lecionar em salas de aula multilingues. O instrumento utilizado foi um questionário criado pelo Grupo Multilingue da Rede Europeia de Literacia traduzido e adaptado para Portugal que foi respondido online. Os resultados mostram uma baixa concentração de imigrantes por turma, o lugar de destaque do inglês como segunda língua, professores com uma atitude de abertura face à diversidade linguística, multilingues e esclarecidos acerca do multilinguismo, valorizando a língua e cultura dos estudantes. Acreditam que o conhecimento de línguas se constitui como uma mais-valia no desenvolvimento académico e cognitivo dos estudantes.