bluuebunny/crossref_metadata_2025 huggingface dataset:
A re-assessment of gene-tag classification approaches for describing var gene expression patterns during human Plasmodium falciparum malaria parasite infections
Authors: Githinji George , Bull Peter C.
Published: September 2017

PfEMP1 are variant parasite antigens that are inserted on the surface of Plasmodium falciparum infected erythrocytes (IE). Through interactions with various host molecules, PfEMP1 mediate IE sequestration in tissues and play a key role in the pathology of severe malaria. PfEMP1 is encoded by a diverse multi-gene family called var. Previous studies have shown that that expression of specific subsets of var genes are associated with low levels of host immunity and severe malaria. However, in most clinical studies to date, full-length var gene sequences were unavailable and various approaches have been used to make comparisons between var gene expression profiles in different parasite isolates using limited information. Several studies have relied on the classification of a 300 – 500 base-pair “DBLα tag” region in the DBLα domain located at the 5’ end of most var genes.

We assessed the relationship between various DBLα tag classification methods, and sequence features that are only fully assessable through full-length var gene sequences. We compared these different sequence features in full-length var gene from six fully sequenced laboratory isolates.

These comparisons show that despite a long history of recombination, DBLα sequence tag classification can provide functional information on important features of full-length var genes. Notably, a specific subset of DBLα tags previously defined as “group A-like” is associated with CIDRα1 domains proposed to bind to endothelial protein C receptor.

This analysis helps to bring together different sources of data that have been used to assess var gene expression in clinical parasite isolates.
A NonCooperative Approach to Cost Allocation in Joint Replenishment
Authors: He Simai , Sethuraman Jay , Wang Xuan , Zhang Jiawei
Published: September 2017

We consider the infinite-horizon multiple retailer joint replenishment problem with first-order interaction. In this model, the joint setup cost incurred by a group of retailers placing an order simultaneously consists of a group-independent major setup cost and retailer-specific minor setup costs. The goal is to determine an inventory replenishment policy that minimizes the long-run average system-wide cost. In this paper, we adopt a noncooperative approach to study the joint replenishment game. We consider the allocation rule in which the major setup cost is split equally among the retailers who place an order together, and each retailer pays his own holding and minor setup costs. Given the preannounced allocation rule, each retailer determines his replenishment policy to minimize his own cost anticipating the other retailers’ strategy. We show that a payoff dominant Nash equilibrium exists, and quantify the efficiency loss of the noncooperative outcome relative to the social optimum. Although the worst-case ratio between the best decentralized outcome and the social optimum is O((ln n)1/2), where n is the number of retailers, numerical results suggest that the best equilibrium is near optimal.

The online appendix is available at https://doi.org/10.1287/opre.2017.1645 .
Livros e Bibliotecas: encontros (in)dispensáveis no processo de aprendizagem?
Authors: Alarcão Madalena
Published: September 2017

O presente artigo foca-se na importância dos livros, e de uma leitura reflexiva, no processo de aprendizagem e na qualidade da formação do estudante universitário.Interroga-se sobre como pode a Universidade estimular caminhos de aprendizagem em que os estudantes sentem necessidade de ler livros e de frequentar bibliotecas. Se os docentes podem, nesta matéria, ser importantes modeladores do comportamento dos estudantes, também os bibliotecários, enquanto “curadores de informação” e “conselheiros de procedimentos” têm um papel muito relevante na promoção de sessões de consulta de bases de dados e utilização de sistemas de referenciação e escrita científica.
Joaquim de Carvalho: o clerc universitário
Authors: De Carvalho Paulo Archer
Published: September 2017

Professor, bibliotecário, bibliólogo, editor universitário, Joaquim de Carvalho (1892-1958) é investigador e autor pioneiro, entre nós, de uma historiografia cultural de matriz filosófica e da história das ideias, tal como a esboçaram Windelband e Dilthey no ocaso e na transição do século XIX e se praticara, com Collingwood, na primeira metade do século XX. No fulcro dessa longa duração que sinaliza afinal a viragem para a agonia eurocêntrica e durante a qual a intelectualidade europeia mais se cindiu sobre o seu próprio estatuto – arguição cuja peça-chave é o célebre manifesto polémico La Trahison des clercs, de Julian Benda – Joaquim de Carvalho patenteou o paradigma do clerc secular: Ou, se quisermos, do universitário que, avançando na episteme espinosiana, apenas se subjuga à sua própria consciência e que, à maneira kantiana, da sua livre ética da responsabilidade transforma em dever deontológico.
Variantes de um poema juvenil de Mário de Sá-Carneiro
Authors: Do Amaral A. E. Maia
Published: September 2017

Dá-se a conhecer o pequeno núcleo de livros de infância de Mário de Sá-Carneiro (1890-1916) conservado na Biblioteca Geral da Universidade de Coimbra, e alguns versos neles manuscritos que se revelam como variantes inéditas do poema de juventude “Quadras para a Desconhecida”.
Os benfeitores de pobres nas Misericórdias do Minho (séculos XVII-XVIII)
Authors: Lobo de Araújo Maria Marta
Published: September 2017

Neste trabalho analisamos os benfeitores das Misericórdias do Minho dos séculos XVII e XVIII, destacando o seu contributo para as práticas de caridade destas instituições. Ao mesmo tempo, chamamos a atenção para a importância dos seus legados para a constituição e reforço do património destas confrarias, demonstrando como as preocupações com a salvação da alma os aproximaram dos pobres e se refletiram no crescimento do seu património material e imaterial.Situadas numa região de forte emigração para o Brasil, as Misericórdias do Minho receberam importantes legados de benfeitores “brasileiros”, incrementando a distribuição de dotes de casamento, a assistência à doença e a dádiva de esmolas aos pobres. Porém, não apenas estes, mas muitos outros beneficiaram as Santas Casas na esperança de salvarem a sua alma.
Homens viciosos de vivo entendimento: os espanhóis da América como sujeitos de reforma pela dieta no tratado de Juan de Cárdenas (México, 1591)
Authors: Varella Alexandre C.
Published: September 2017

Problemas y secretos maravillosos de las Indias, do médico Juan de Cárdenas formado na Universidad de México, é o objeto central da análise. Está no cerne do tratado do imigrante a instrução, senão admoestação aos espanhóis nascidos ou criados no Novo Mundo por seguir as regras de dieta numa terra de clima tropical, com alimentos e hábitos diferentes da Espanha e em boa parte emprestados aos indígenas. Procurador da distinção social em termos aristocráticos e doutos, busca um sujeito ideal, que teria corpo de compleição sanguínea e colérica, para usufruir com cuidado a região que traria enfermidades fleumáticas. O criollo devia selecionar práticas ancestrais e precaver-se de crenças e invenções culinárias no cadinho de povos e tipos sociais. O principal objetivo do artigo, portanto, é analisar o discurso que seja do profissional ou professoral de Cárdenas, por modificar pela dieta os espanhóis bem nascidos na América.
Graphentechnologien in den Digitalen Geisteswissenschaften
Authors: Kuczera Andreas
Published: September 2017

Vernetzung ist ein vielgenutzer Begriff und wird meist in einem positiven Kontext verwendet. Oft sind heute die Vernetzung von Daten und Wissen zentrale Bestandteile der Entwicklung von Lösungsansätzen aktueller (Forschungs-)Fragestellungen. Für den Bereich der digitalen Geisteswissenschaften zeigt sich diese Entwicklung vor allem im zunehmenden Einsatz von Graphentechnologien in den verschiedensten Projekten. In diesem Beitrag werden exemplarisch sechs Anwendungsfälle vorgestellt und abschließend ein kurzer Ausblick auf Vorteile und Herausforderungen bei der Nutzung von Graphentechnologien im Bereich der digitalen Geisteswissenschaften und der Infrastrukturprovider gegeben.
Gemeinsam die Zukunft gestalten: Das Projekt Swiss Library Service Platform (SLSP)
Authors: Capatt Iris , Neubauer Wolfram
Published: September 2017

Vor etwa drei Jahrzehnten wurde der erste Bibliotheksverbund der Schweiz gegründet. Seither hat sich im Bereich der wissenschaftlichen Bibliotheken eine stark diversifizierte Verbundlandschaft entwickelt, deren Sinn und deren Zukunftsfähigkeit seit einigen Jahren intensiv diskutiert wird. Mit dem im Jahr 2015 initiierten nationalen Bibliotheksprojekt Swiss Library Service Platform (SLSP) haben sich Bibliotheken und Hochschuleinrichtungen des ganzen Landes erstmals gemeinsam zum Ziel gesetzt, der wissenschaftlichen Community ein breites Spektrum an Dienstleistungen zu vermitteln, zu unterstützen und selbst anzubieten. Der vorliegende Beitrag blickt zunächst auf die Ausgangslage des Projekts zurück, beschreibt dann die Randbedingungen und die erreichten Ziele der ersten beiden Projektphasen und gibt anschließend einen Ausblick auf die Realisierung, die für die Jahre 2018–2020 vorgesehen ist.
Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience
Authors: Suzuki Satoshi , Togari Hajime , Potenziano Jim L. , Schreiber Michael D.
Published: September 2017

Objective:

To analyze data from a registry of Japanese neonates with hypoxic respiratory failure associated with pulmonary hypertension (PH) to compare the effectiveness of inhaled nitric oxide (iNO) in neonates born <34 weeks vs. ≥34 weeks gestational age (GA).

Materials and methods:

iNO was administered according to approved Japanese product labeling. Study data were collected before iNO administration and at predefined intervals until discontinuation.

Results:

A total of 1,114 neonates were included (n=431, <34 weeks GA; n=675, ≥34 weeks GA; n=8, missing age data). Mean decrease from baseline oxygenation index (OI) was similar in both age groups. OI reduction was more pronounced in the <34 weeks subgroups with baseline OI ≥25. Survival rates were similar in the <34 weeks GA and ≥34 weeks GA groups stratified by baseline OI (OI<15, 89% vs. 93%; 15≤OI<25, 85% vs. 91%; 25≤OI≤40, 73% vs. 79%; OI>40, 64% vs. 66%).

Conclusion:

iNO improved oxygenation in preterm neonates as effectively as in late preterm and term neonates, without negative impact on survival. If clinically significant PH is present, as measured by pulse oximetry or echocardiography, a therapeutic trial of iNO might be indicated for preterm neonates.
Substance Use in Youth With Borderline Personality Disorder
Authors: Scalzo Franco , Hulbert Carol A. , Betts Jennifer K. , Cotton Sue M. , Chanen Andrew M.
Published: September 2017

Co-occurring substance misuse and borderline personality disorder (BPD) in adults is associated with more severe dysfunction and poorer prognosis than BPD alone. However, it is unknown to what extent substance use in youth with BPD is normative for this age group or pathological. This study compared substance use in 117 help-seeking youth (aged 15–25 years) with their first presentation for treatment of BPD, with an epidemiological general population sample and with healthy, age- and gender-matched controls. Established instruments were used to diagnose BPD and assess substance use. Alcohol dependence, daily tobacco use, and use of illicit substances in the past month were between four and nine times more prevalent in the BPD group than in the general population. Similarly, the prevalence of substance use was disproportionately higher in youth with BPD than in matched controls. The findings indicate a non-normative, alarmingly high rate of substance use among youth with BPD.
Reward-Related Ventral Striatum Activity Buffers against the Experience of Depressive Symptoms Associated with Sleep Disturbances
Authors: Avinun Reut , Nevo Adam , Knodt Annchen R. , Elliott Maxwell L. , Radtke Spenser R. , Brigidi Bartholomew D. , Hariri Ahmad R.
Published: September 2017

Sleep disturbances represent one risk factor for depression. Reward-related brain function, particularly the activity of the ventral striatum (VS), has been identified as a potential buffer against stress-related depression. We were therefore interested in testing whether reward-related VS activity would moderate the effect of sleep disturbances on depression in a large cohort of young adults. Data were available from 1129 university students (mean age 19.71 ± 1.25 years; 637 women) who completed a reward-related functional MRI task to assay VS activity and provided self-reports of sleep using the Pittsburgh Sleep Quality Index and symptoms of depression using a summation of the General Distress/Depression and Anhedonic Depression subscales of the Mood and Anxiety Symptoms Questionnaire-short form. Analyses revealed that as VS activity increased the association between sleep disturbances and depressive symptoms decreased. The interaction between sleep disturbances and VS activity was robust to the inclusion of sex, age, race/ethnicity, past or present clinical disorder, early and recent life stress, and anxiety symptoms, as well as the interactions between VS activity and early or recent life stress as covariates. We provide initial evidence that high reward-related VS activity may buffer against depressive symptoms associated with poor sleep. Our analyses help advance an emerging literature supporting the importance of individual differences in reward-related brain function as a potential biomarker of relative risk for depression.

SIGNIFICANCE STATEMENTSleep disturbances are a common risk factor for depression. An emerging literature suggests that reward-related activity of the ventral striatum (VS), a brain region critical for motivation and goal-directed behavior, may buffer against the effect of negative experiences on the development of depression. Using data from a large sample of 1129 university students we demonstrate that as reward-related VS activity increases, the link between sleep disturbances and depression decreases. This finding contributes to accumulating research demonstrating that reward-related brain function may be a useful biomarker of relative risk for depression in the context of negative experiences.
Primary Generators of Visually Evoked Field Potentials Recorded in the Macaque Auditory Cortex
Authors: Kajikawa Yoshinao , Smiley John F. , Schroeder Charles E.
Published: September 2017

Prior studies have reported “local” field potential (LFP) responses to faces in the macaque auditory cortex and have suggested that such face-LFPs may be substrates of audiovisual integration. However, although field potentials (FPs) may reflect the synaptic currents of neurons near the recording electrode, due to the use of a distant reference electrode, they often reflect those of synaptic activity occurring in distant sites as well. Thus, FP recordings within a given brain region (e.g., auditory cortex) may be “contaminated” by activity generated elsewhere in the brain. To determine whether face responses are indeed generated within macaque auditory cortex, we recorded FPs and concomitant multiunit activity with linear array multielectrodes across auditory cortex in three macaques (one female), and applied current source density (CSD) analysis to the laminar FP profile. CSD analysis revealed no appreciable local generator contribution to the visual FP in auditory cortex, although we did note an increase in the amplitude of visual FP with cortical depth, suggesting that their generators are located below auditory cortex. In the underlying inferotemporal cortex, we found polarity inversions of the main visual FP components accompanied by robust CSD responses and large-amplitude multiunit activity. These results indicate that face-evoked FP responses in auditory cortex are not generated locally but are volume-conducted from other face-responsive regions. In broader terms, our results underscore the caution that, unless far-field contamination is removed, LFPs in general may reflect such “far-field” activity, in addition to, or in absence of, local synaptic responses.

SIGNIFICANCE STATEMENTField potentials (FPs) can index neuronal population activity that is not evident in action potentials. However, due to volume conduction, FPs may reflect activity in distant neurons superimposed upon that of neurons close to the recording electrode. This is problematic as the default assumption is that FPs originate from local activity, and thus are termed “local” (LFP). We examine this general problem in the context of previously reported face-evoked FPs in macaque auditory cortex. Our findings suggest that face-FPs are indeed generated in the underlying inferotemporal cortex and volume-conducted to the auditory cortex. The note of caution raised by these findings is of particular importance for studies that seek to assign FP/LFP recordings to specific cortical layers.
The Emergence and Growth of Materials Science in Swedish Universities
Authors: Gribbe Johan , Hallonsten Olof
Published: September 2017

The cross-disciplinary field of materials science emerged and grew to prominence in the second half of the twentieth century, drawing theoretical and experimental strength from the rapid progress in several natural sciences disciplines and connecting to many industrial applications. In this article, we chronicle and analyze how materials science established itself in Swedish universities in the 1960s and after. We build on previous historical accounts of the growth of materials science elsewhere, especially in the United States, and the conceptual guidance that these studies offer. We account for the emergence and growth of materials science in Sweden from the early influences brought back by academics from postdoc stays in the United States, through the creation of the first funding programs in the late 1970s, to the breakthrough of materials science in Sweden in the 1990s and its growth to a true area of strength and priority in Swedish science today. In line with previous studies, we highlight the role of funding agencies, providing the means for new cross-disciplinary activities across and between traditional disciplinary structures, and the role of new instrumentation, providing new experimental opportunities and uniting disciplinarily disparate research activities around common goals, as crucial in the process. Also, the role of entrepreneurially minded individuals is evident in the story: materials science was developed in Sweden largely by a new generation of scientists who established new activities within existing organizational structures, and thus accomplished long-term institutional change in a well-established field and system.
Young Jazz Musicians and Negotiation of Public Space in Yogyakarta Indonesia
Authors: Sutopo Oki Rahadianto
Published: September 2017

Using Bourdieusian approach, this article explores the reflexive strategies of young jazz musicians in order to develop their musical practices in a contemporary urban context of Yogyakarta, a city of culture and activism in Indonesia. In detail, the reflexive strategy (Sweetman 2003; Threadgold Nilan 2009) will be explained as the manifestation of struggle in the field of cultural production (Bourdieu 1993). As an implication, young jazz musicians have to negotiate their musical practices with the reproduction of doxa and the representation of dominant agents in the jazz music field including the availability of public spaces in contemporary Yogyakarta. The resistance towards doxa will be explained based on the local narratives of the Yogyakarta jazz community as a mixture of the local and the trans-local scene (Bennett Peterson 2004). Furthermore, the reflexive strategy will be analysed through the lens of the youth culture perspective specifically as a manifestation of a mixture between post-subculture (Bennett 1999) and subculture (Blackman 2005). In their everyday musical practices, young jazz musicians produce their musical practices fluidly and flexibly as a lifestyle distinction as well as a form of everyday life resistance. In summary, this article shows the complexity of the musical processes of young jazz musicians in contemporary urban space of Yogyakarta, Indonesia.
Investigating the Political Base of Indonesian Middle Class: A Comparative Study
Authors: Jati Wasisto Raharjo
Published: September 2017

This article aims at analyzing the political base in the case of Indonesian middle class. It is essential to note that many multi-interpretation understandings to define terminology of Indonesian middle class. The definition of Indonesian middle class still undermines as “middle group” which is related to new rich people. Based on comparative analyzes, the emergence of Indonesia middle class have been separated with western middle class. In western case, middle class has possessed stable economic and politics material sources independently toward the state. The situation is what transforms the middle class as presser to the states and interest group. It can be said that both processes of the deepening of democratization and economic strength have been encouraged by middle class. In the Indonesian experience, it has been shown that Indonesian middle class keep up mutual relationship to the state. In other words, Indonesian middle class have entered elite power structure. However, in the current time, Indonesian middle class in post-reformation era shows the emergence of political awareness to guard democracy justly. This article will elaborate deeply political basis of Indonesian middle class.
Strategy of Ethnic Identity Negotiations of Javanese Migrants Adolescents in Family Interaction
Authors: Aryanti Nina Yudha
Published: September 2017

This article seeks to discuss the strategies of negotiation of Javanese ethnic identity in families among Javanese migrants in Lampung. The study found that there are three ways where the adolescents of Javanese migrants negotiate their ethnic identity. First, the adolescent states Javanese ethnic identity as a positive identity safely at family interaction. Second,they state Javanese ethnic identity as a single identity negatively in an unsafe situation. This happens when the adolescent avoid another ethnic identity that directed to them based on labeling in the family. Third, the adolescent choose one of two ethnic identities in a positive way. It’s referring to parent’s ethnic identity differences. Further, they use Javanese and non Javanese language at their family interaction as a basis for selecting ethnic identity.
Cembranoids of Soft Coral Sarcophyton from Acidified Coral Reef Environment at Shallow Water CO2 vents in Volcano Island, Banda Neira, Indonesia
Authors: Januar Hedi Indra , Zamani Neviaty Putri , Soedharma Dedi , Chasanah Ekowati
Published: September 2017

Cembranoid content in soft coral is known as a chemotype that relate with genotype and environment. This research aimed to characterize the cembranoid Sarcophyton soft coral from the reef that acidified by CO2 volcanic vents (pHT 7.8) at Volcano Islands waters, Banda-Neira (Indonesia), as a means of predicting the future impact of ocean acidification to the genetic diversity of Sarcophyton soft coral. 30 random colonies were taken, combined, and extracted with ethanol. Cembranoid isolation and identification had been done by high performance liquid chromatography and spectrometry techniques. Results of the study found sarcophytol derivatives (sarcophytol A, 11,12-epoxy sarcophytol A, sarcophytol B, and sarcophytol M) as the only chemotype in the sample. This may suggest low genetic diversity in the observed Sarcophyton sample. Therefore, it may suggest that even soft coral is known to be resilient to future acidification pressures, the genetic diversity or the production of diverse cytotoxic metabolite may be hampered due to ocean acidification in future climate change adaptation.
COMO OS DOCENTES DE CURSOS TÉCNICO INTEGRADOS COMPARTILHAM A GESTÃO DA INDISCIPLINA
Authors: Rodrigues Icaro Alencar , Gomes Márcia Costa , Marques Larissa Carvalho
Published: September 2017

A indisciplina é um fator presente no âmbito educacional e, por ter uma complexidade de causas que a propiciam, requer um trabalho em conjunto de todos os atores educacionais. Para tanto esta pesquisa de campo e explicativa tem como objetivo investigar, por meio de questionário, como os docentes que lecionam nos Cursos Técnicos Integrados ao Ensino Médio do Instituto Federal de Educação, Ciência e Tecnologia da Paraíba – Câmpus Campina Grande gerenciam a indisciplina em sala de aula, mais especificamente como ocorre a gestão compartilhada dos comportamentos indisciplinados dos discentes em sala de aula, entre professores e demais setores e agentes educacionais desta instituição. Os resultados apontam que a maior parte dos professores investigados não solicita auxílio para tratar de questões de indisciplina, e para aqueles que costumam solicitar ajuda apenas raramente o fazem, assim como a Coordenação Pedagógica, a Coordenação de Assistência ao Estudante e as Auxiliares Educacionais são as principais fontes de apoio para a maioria. Os resultados deste trabalho ampliam a possibilidade de se investigar, por exemplo, os motivos que levam os docentes a não solicitarem apoio mediante os casos de indisciplina.
DIAGNÓSTICO DE PRÁTICAS DE REDUÇÃO DOS IMPACTOS AMBIENTAIS NO ENTORNO ADOTADAS POR OBRAS RESIDENCIAIS DE DIFERENTES REGIÕES DA CIDADE DE SÃO PAULO (SP)
Authors: Paschoalin Filho João Alexandre , Lima Bezerra Paulo Roberto , Faria Ana Cristina de , De Oliveira Larissa Regina Gonçalves Jacintho
Published: September 2017

A Construção Civil consiste em importante agente de desenvolvimento do país. Contudo, responde por significativos impactos ambientais decorrentes de suas atividades. Dentre os impactos causados pelas obras, destacam-se àqueles que ocorrem durante a etapa executiva dos edifícios, principalmente na região do entorno destes, tais como: poluição sonora, contaminação do solo, sujeira de vias, poeira, entupimento de sistemas de drenagem de águas pluviais etc. Dentro deste contexto, esta pesquisa objetiva determinar se construtoras localizadas na cidade de São Paulo adotam, em suas obras, ações de sustentabilidade, de forma a mitigar impactos decorrentes de suas atividades e cumprir legislações ambientais. A metodologia empregada foi o estudo de casos múltiplos em nove obras, com abordagem exploratória e análise quantitativa. Para tal, foi elaborado um checklist com itens baseados em recomendações de sistemas de certificação Green Building (LEED, Processo ACQUA e Selo Casa Azul). A ferramenta de pesquisa foi submetida à avaliação de juízes e, posteriormente, utilizada em visitas realizadas nas obras. Por meio da análise dos dados pode-se constatar que nem todas as construtoras possuíam preocupação com ações de mitigação de impacto de suas obras na vizinhança onde estas se encontravam.
METODOLOGIA DE AVALIAÇÃO DE CARDÁPIO SUSTENTÁVEL PARA SERVIÇOS DE ALIMENTAÇÃO
Authors: Mota Êmily Bezerra Fernandes , Bezerra Ingrid Wilza Leal , Seabra Larissa Mont´Alverne Jucá , Silva Gidyenne Christine Bandeira , Rolim Priscilla Moura
Published: September 2017

A elaboração de cardápios saudáveis sob a ótica da produção sustentável é uma tendência mundial entre gestores de serviços de alimentação. O objetivo do estudo foi elaborar uma ferramenta de avaliação para setor de alimentação coletiva, no que diz respeito à produção de refeições e cardápios sustentáveis. Utilizou-se como embasamento científico revisão de literatura nacional e internacional sobre sustentabilidade em serviços de alimentação, e elaborou-se um questionário de verificação. Este questionário foi aplicado em uma UAN institucional e constatou-se conformidade em 70,3% dos itens avaliados. Destacou-se o desenvolvimento de ações relacionadas a geração de resíduos sólidos e a oferta de variedade das escolhas alimentares, embora, não tenha sido realizada auditoria energética e as refeições não apresentarem adequação total quanto à qualidade nutricional. Diante da relevância e escassez de estudos com propostas de avaliação de cardápios sustentáveis que auxiliem gestores, alunos e professores para aplicação de práticas voltadas para a sustentabilidade, sobretudo visando o atendimento legal vigente, o questionário desenvolvido auxiliará estes profissionais para uma gestão contemporânea, facilitando a implantação de ações sustentáveis na produção de refeições. A relevância do tema e escassez de trabalhos que apresentem ferramentas que propiciem adoção de práticas sustentáveis na produção de refeições ressaltam a importância de mais estudos voltados para esta temática. O instrumento desenvolvido nesta pesquisa é de fácil aplicação e contempla as recomendações mundiais da Associação Americana de Nutricionistas, desta forma, almeja-se que seja utilizado por profissionais dos serviços de alimentação visando adoção de ações sustentáveis na produção de refeições.
ELEMENTOS-TRAÇO EM ÁGUAS, SEDIMENTOS E SOLOS DA BACIA DO RIO DAS MORTES, MINAS GERAIS
Authors: Zuliani Daniela Queiroz , Abreu Lívia Botelho , Curi Nilton , Carvalho Geila Santos , Costa Adriana Monteiro , Marques João José
Published: September 2017

O objetivo deste estudo foi determinar os teores de elementos-traço em solos de planícies de inundação e em sedimentos de fundo de rios para identificar áreas contaminadas por esses elementos comparando os teores obtidos em locais com e sem interferência antrópica. Foram amostradas águas superficiais, sedimentos e solos em 80 locais na Bacia do Rio das Mortes, em Minas Gerais, para determinação de Cd, Cu, Cr, Ni, Pb, Mn e Zn. Das 80 amostras, 40 localizavam-se em locais suspeitos de contaminação e 40 em locais-controle, denominados “locais naturais”. Os resultados mostraram que, na Bacia do Rio das Mortes, a agricultura não constitui um fator relevante de incremento dos elementos-traço estudados. Porém, verifica-se grande influência de centros urbanos, industrializados ou não, na dispersão de elementos-traço para o ambiente. Foi verificada contaminação nos solos das planícies de inundação por Pb nos Municípios de Dores de Campos e Prados, Cu, Cr, Ni, Pb e Mn em Nazareno e São Tiago, Cr e Ni em São João Del Rei e Cu em Barbacena.
CARACTERIZAÇÃO DE AGREGADO MIÚDO FORNECIDO NA MICRORREGIÃO DO AGRESTE POTIGUAR, POPULARMENTE DENOMINADO “AREIA BARRADA”.
Authors: Mendonça de Souza Maelson , Luiz de Oliveira Silva André , Virgínia Gomes Pina Lara
Published: September 2017

Profissionais de diversas áreas do conhecimento buscam incessantemente descobrir ou criar novos materiais para aplicação no setor da construção civil visando a proporcionar avanços tecnológicos e redução dos custos. Dessa forma, até a areia lavada, material básico para construção civil, dentro da qual seu uso está consolidado, possui novos concorrentes, os quais se apresentam com algum diferencial em relação ao agregado miúdo em questão. Antes de chegar ao canteiro de obras, um agregado deve necessariamente passar por uma série de avaliações a fim de se garantir que é realmente confiável. Para tanto, o setor da construção civil conta com o auxílio das normas técnicas elaboradas pela Associação Brasileira de Normas Técnicas (ABNT). Tendo isso em vista, este artigo pretende caracterizar um agregado miúdo popularmente denominado “areia barrada”, amplamente utilizado na produção de argamassas e de concretos estruturais na microrregião agreste do estado Rio Grande do Norte. Ensaios de massa unitária, massa específica, granulometria, inchamento, determinação do teor de argila em torrões, determinação do teor de materiais pulverulentos e determinação de impurezas orgânicas, permitiram a avaliação da qualidade e a aplicabilidade deste material para construção civil. Assim, foi possível observar que o agregado miúdo apresentou uma série de inconformidades, fato preocupante, uma vez que vem sendo aplicado indiscriminadamente sem um atestado de conformidade balizado pelas normas técnicas vigentes. Diante disso, a pesquisa objetiva garantir a qualidade das argamassas e dos concretos estruturais produzidos na região mencionada.
Editorial
Authors: Leite José Yvan Pereira
Published: September 2017

A educação, a ciência e a tecnologia brasileira sofre graves cortes em seus orçamentos, bem como desloca os esforços da comunidade acadêmica à luta pela manutenção dos investimentos no presente e no futuro da grande nação brasileira.O novo número da HOLOS reforça os esforços deste periódico para a comunicação,  cooperação e difusão científica com caráter internacional. Este é refletido nos artigos advindos dos vários estados brasileiros, bem como de Cuba, Espanha, Irã, México, Portugal, Polônia. A diversidade reflete a importância das publicações de acesso aberto e confirma que esta modalidade influencia em seu protagonismo.Para reafirmar este quadro de evolução são apresentados abaixo dados comparativos de acessos  dos períodos de 1o de janeiro a 17 de setembro dos anos de 2016 e 2017 obtidos no Google Analytics. Quadro 1 – Dados de acesso à HOLOS. 01/01/2016 a 17/09/2016(n)01/01/2017 a 17/09/2017(n)Evolução(%)Número de Usuários72.80790.264+24Visualizações370.511433.583+17Duração Média (min)2,982,68- 10Fonte – Google Analytics.Os dados refletem os acessos diretos do site do periódico e demonstram um crescimento do números de acessos e de visualizações. A duração média do acesso apresenta uma redução da ordem de 6%.Como estratégia para reduzir o tempo de publicação, o periódico passa a definir a ordem de aparição dos artigos no sumário de acordo com a avaliação, assim este procedimento deve dar maior celeridade ao processo de publicação.Em um mundo globalizado e do conhecimento, os instrumentos protagonizados pela lei que criou as Escolas de Aprendizes e Artífices, se alteram do plano manual para a automação, do impresso ao virtual. No entanto, se mantém  o compromisso com a utopia da formação da classe trabalhadora. Esta deve estar à altura  daqueles que façam a nação vislumbrar perenidade nas políticas de desenvolvimento social!Enfim, convido-os a acessarem o sumário e, quando possível, difundir entre vossas redes sociais.Natal,  18 de setembro de 2017. José Yvan Pereira Leite
Setting up and maintaining a dedicated student-led peer-assisted learning society: our experience and recommendations
Authors: Davies Kristen , Rousseva Christiana , Khojani Huzaifah , Kyrtata Natalia , Khoda Fatimah , Heyworth Joanna
Published: September 2017

This article was migrated. The article was marked as recommended. Peer-assisted learning (PAL) is becoming increasingly popular within medical education, reflected by the amount of literature on the subject. There are numerous benefits of PAL for both teachers, students and faculty. At Lancaster Medical School, we decided to first investigate whether students wanted a student-led PAL society. Following the results, we set up the Lancaster University Peer-Assisted Learning Society (LUPALS) in 2013. Since its foundation, LUPALS has successfully provided over 100 teaching sessions to medical students at Lancaster Medical School. We have highlighted the important aspects of setting up our PAL society with reference to the evidence base and provided recommendations for others who are considering creating their own PAL society at their institution. We conclude that setting up LUPALS has been a successful venture and should act as encouragement for others who wish to do the same.
Dephosphorylation of 5' -ends of DNA using AnP (M0289) v2
Authors: England Biolabs New
Published: September 2017

This is the protocol for dephosphorylation of 5'-ends of DNA using AnP (Antarctic Phosphatase - M0289).
ENSAYO DE CICATRIZACIÓN IN VITRO, PARA EVALUAR MIGRACIÓN CELULAR v1
Authors: Palacio Jesica , Johanna Toro Lily , Alberto Téllez Ramírez Germán , Pablo Bedoya Agudelo Juan , Carolina Henao Diana , Carlos Castaño Osorio Jhon
Published: September 2017

El ensayo de herida o ruptura in vitro, es un método fácil, de bajo costo y bien desarrollado para medir migración celular in vitro. Los pasos básicos implican la creación de una “herida” en una monocapa celular, capturando las imágenes al principio y en intervalos regulares de tiempo durante la migración celular para cerrar la herida y comparar las imágenes para cuantificar la tasa migración de las células.
Decolonial Perspectives on Charitable Spaces of “Welcome Culture” in Germany
Authors: Braun Katherine
Published: September 2017

This article focusses on the relationships between volunteers and refugees in the German “welcome culture”. I highlight the continuities between historical and colonial notions of feminine charity and contemporary volunteering efforts in support of refugees in Germany. The “welcome culture” is conceived here as a charitable space that is historically sedimented by specific understandings of gender, racial and class difference. In particular, the difference between the modern emancipated female volunteer and the female oppressed refugee plays a central role. The question of female self-determination, then, becomes an important social arena in the German “welcome culture”, through which the rate and terms of participation of refugees in social life are negotiated. Thus I draw on decolonial thought as well as theoretical insights from post-development scholarship and critical studies of humanitarianism in order to consider the multitemporal and transnational character of current “welcome culture” as well as to gain a better understanding of the entailed power relations. These are more contingent than might first appear. Presenting findings from my ongoing fieldwork I conclude that the notion of “welcome culture” allows for the emergence of new forms of sociality.
Migration Regimes and the Translation of Human Rights: On the Struggles for Recognition of Romani Migrants in Germany
Authors: Leko Jure
Published: September 2017

The current claims for asylum and refugee protection of Roma from the so-called “Western Balkan states” are rejected by the German state. Based on this practice, Romani migrants are not recognized as genuine refugees but classified as irregular migrants and thus labeled as “bogus” asylum seekers. This article discusses the discursive process through which the legal status of Romani migrants is irregularized within the German migration regime. Furthermore, through an empirical study, the article shows how Romani organizations and migrants are struggling for a collective right to remain in Germany. In their political-legal struggles for recognition, Roma reinterpret not only their legal status as irregular migrants, but also their legal-cultural practices: by appropriating the semantics of human rights through the lenses of their cultural backgrounds. This, in turn, shifts the analytical focus to the productivity of human rights discourses. They are assumed to be an effective tool to enforce legal claims against the German migration regime. In this context, the article examines legal-cultural practices, which become visible in the struggle, by exploring six justification narratives—through these, the Roma’s political-legal belonging to the German nation-state shall be legitimized.
Perspectives of Statistics as a Scientific Subject at a University
Authors: Strasser Helmut
Published: September 2017

Lecture, given on Nov. 5th, 2003, at the evaluation workshop of the Department ofStatistics, Vienna University of Economics and Business Administration
Finite-Sample Properties of the GLS-Based Dickey-Fuller Test in the Presence of Breaks in Innovation Variance
Authors: Cook Steven
Published: September 2017

Using local-to-unity detrending, the GLS-based Dickey-Fuller test has been shown to possess higher power than other available unit root tests. As a result, application of this easily implemented test has increased in recent years. In the present study the finite-sample size and power of the GLS-based Dickey-Fuller test is examined in the presence of breaks in innovation variance under the null. In contrast to the original Dickey-Fuller test which has been shown to suffer severe distortion in such circumstances, the GLS-basedtest latter exhibits robustness to all but the most extreme breaks in variance.The results derived show the GLS-based test to be more robust to variance breaks than other modified Dickey-Fuller tests previously considered in the literature.
Nachruf: Prof. Dr. Dr. h.c. Leopold SCHMETTERER
Authors: Pflug Georg
Published: September 2017

Nachruf: Prof. Dr. Dr. h.c. Leopold SCHMETTERER (* 8. November 1919, y24. August 2004)
On the Product and Ratio of Pearson Type VII and Laplace Random Variables
Authors: Nadarajah Saralees , Kotz Samuel
Published: September 2017

The distributions of the product |XY|  and the ratio |X/Y| are derived when X and Y are Pearson type VII and Laplace random variables distributed independently of each other. Extensive tabulations of the associated percentage points are also given.
A Simple Encompassing Test for the Deterministic and Bilinear Unit Root Models
Authors: Charemza Wojciech W. , Makarova Svetlana
Published: September 2017

A new parameters’ encompassing test is proposed for deciding between the deterministic unit root processes with a structural break and the bilinear unit root model without such break. The test consists in testing three sets of hypotheses regarding parameters in a simple regression model. The test uses the t-ratio and F-statistics, of non-trivial distributions under the null hypothesis. The finite sample distributions for the relevant statistics are tabulated and the asymptotic distribution of the F-test is derived. The test has been applied for the daily stock price indices for 66 countries, for the period 1992-2001. The results support the conjecture that the bilinear model dominates the structural break model more often than the other way around. Also, it is likely that in practical applications the bilinear unit root process might be mistaken for the deterministic unit root process with a structural break.Financial support of INTAS project No. 03-51-3714 Nonstationary multivariate and nonlinear econometric models: theory and applications is gratefully acknowledged.
Robust Sequential Testing of Hypotheses on Discrete Probability Distributions
Authors: Kharin Alexey , Kishylau Dzmitry
Published: September 2017

The paper is devoted to analysis of approximations of the models in sequential hypotheses testing and to construction of new robust sequential test under the distortions presented by mixtures of probability distributions. The previous results of the authors are extended to the case of arbitrary discrete probability distributions. The theory is illustrated by computer modelling.
A Foreword from the Editor
Authors: Gu Ji-Dong
Published: September 2017

N/A
Nasal flora in allergic rhinitis
Authors: Rajasekaran Valli , B. V. Sharath Kumar , Sriraman Gurumani
Published: September 2017

Background: Allergic rhinitis is a common cause for recurrent rhinosinusitis. The microbiology in allergic nasal mucosa has not been much documented. The aim of the study is to identify the microbes in the middle meatus in patients with allergic rhinitis and to compare with the normal nasal flora.

Methods: A cross sectional study was conducted in our institute to study the nasal microbial pattern in 50 patients with allergic rhinitis and was compared with 50 normal healthy nasal flora. Nasal swabs were taken from middle meatus under endoscopic guidance in both the groups and sent for microbial analysis.  

Results: Organisms like Klebsiella, E.coli, and Staphylococcus aureus were predominant isolates in patients with allergic rhinitis, whereas Staph epidermidis were predominant in controls.

Conclusions: This alteration in microbial flora could possibly explain recurrent sinonasal infections in patients with allergic rhinitis.
La importancia de la innovación en el producto para generar posicionamiento en los jóvenes
Authors: Giraldo Pérez Wilson , Otero Gómez María Cristina
Published: September 2017

Este artículo de investigación financiado por la Universidad de los Llanos presenta, de forma jerarquizada los factores de innovación que los consumidores aceptan como válidos para mejorar los procesos de posicionamiento y compra de productos que se ofrecen en el mercado. En este caso, los consumidores son jóvenes, hombres y mujeres, con edades que oscilan entre 16 y 24 años, residentes en Villavicencio (Colombia) quienes participaron del estudio cuantitativo. Así se planteó como hipótesis que existe una relación positiva entre las características demográficas del consumidor (edad y nivel socioeconómico) y la innovación del producto; los resultados evidencian que este grupo etario, mayoritariamente, se muestra sensible al análisis económico, puesto que gran parte de ellos dependen financieramente de un adulto y eso limita sus posibilidades de compra y consumo. En orden de importancia jerárquica, para los encuestados, la mayor calificación la obtuvieron los factores de: valor de uso y calidad percibida del producto y la menor calificación corresponde al precio de estos, finalmente, no se evidencia la existencia de correlación alguna asociada a los elementos demográficos de los jóvenes de la ciudad y los factores de innovación.
Neutralidade científica: aspectos éticos na obtenção de resultados
Authors: Duarte da Costa Aznar Fabio , Rodrigues de Freitas Adriana , Maurício Capelari Marcos , Duarte da Costa Aznar Fabiano , De Carvalho Sales-Peres Silvia Helena , Sales-Peres Arsenio
Published: September 2017

La neutralidad en relación con la comunidad científica y publicación de resultados es esencial, en vista de que toda teoría aplicada en las diversas áreas del conocimiento es generada por investigaciones científicas. La manipulación o falsificación de resultados es una de las  prácticas más condenables, ya que difunde datos falsos o incorrectos. Este estudio evaluó si la producción científica y la obtención de resultados estuvieron pautadas en la ética y en el principio de neutralidad, a través de una revisión integradora de la literatura. Los resultados demostraron que en el 100 % de los trabajos seleccionados existe mala conducta científica, y que esta ha aumentado significativamente en todo el mundo, siendo difícil su identificación. Los motivos más comunes para la falsificación de datos fueron la búsqueda de reconocimiento y la competencia en el medio académico. Por lo tanto, una conducta responsable y ética de sociedades y comités científicos, y editores de periódicos se torna imprescindible en la credibilidad de los resultados encontrados en las investigaciones científicas.
En memoria de Omar Parra Rozo
Authors: Baquero Gacharná Mariana
Published: September 2017

Omar Antonio Parra Rozo (1957-2016) fue un hombre de corazón inmenso, memoria prodigiosa y asombrosa inteligencia. Lector incansable, escritor dedicado, educador e investigador y, ante todo, ejemplo de vida. Siempre admiré su generosidad, sencillez y creatividad que plasmaba en sus escritos y en sus clases; su amabilidad al tratar con las personas, su prudencia para manejar situaciones difíciles y su incansable deseo de ayudar. Se destacó en los escenarios laborales, educativos y sociales por su caballerosidad, su responsabilidad, compromiso y buen humor. Mantuvo la idea de conservar las habilidades de los niños, sorprenderse con el mundo y asombrarse con los más pequeños detalles a su alrededor.