bluuebunny/crossref_metadata_2025 huggingface dataset:
Advanced Case of Squamous Cell Carcinoma of the Posterior-Lateral Border of the Tongue Invading the Floor of the Mouth
Authors: Aoun Georges , Toum Sami , Chammas Chirine , Nabbout Fidele
Published: September 2022

Background: Squamous cell carcinoma (SCC) is a common cancer of the oral cavity. It mainly affects patients aged over 50 with male-to-female ratio 2:1. Most of the cases of oral SCC are linked to tobacco and alcohol use. Objective: In this report, we present a case of a 67-year-old male with a mass on the posterior-lateral border of the tongue. Being heavy smoker and alcoholic since a young age, he was at high-risk of developing oral cancer. Case report: Old male of a 67-year-old with Squamous cell carcinoma of the tongue invading the floor of the mouth, who is being heavy smoker and alcoholic since a young age. what was probably one of the reason to be at high-risk of developing oral cancer. After thorough clinical, histopathological, and imaging assessments a poorly differentiated stage III (T3, N1, M0) SCC was confirmed. He underwent left hemiglossectomy with marginal mandibulectomy and radical neck dissection followed by radiation therapy. Conclusion: SCCs of the tongue can be often asymptomatic and identified at advanced phase leading to a poor prognosis. Therefore, their early diagnosis/management, and regular postoperative follow-ups are mandatory for better treatment outcome and recurrence prevention.
The renal protective efficacy of ketamine vs. propofol vs. ketofol against renal ischemia / reperfusion injury: An experimental rat study
Authors: Akdeniz Sevda , Ulu Muhammet , Bakirtas Mustafa , Erdemir Fikret
Published: September 2022

The purpose of this study was to investigate the renal protective efficacy of propofol, ketamine, and ketofol in an ischemia/reperfusion injury (IRI) model experimentally induced in rats. Thirty-five male Sprague-Dawley rats were randomly assigned into five groups: sham (Group 1), control (Group 2), ketamine (Group 3), propofol (Group 4), and ketofol (Group 5). Following administration of intramuscular ketamine hydrochloride anesthesia, the left renal hilum was exposed to 60-minutes clamping. Ketamine (Group 3), propofol (Group 4), and ketofol (Group 5) were administered 15 min prior to reperfusion. After six hours of reperfusion, the left kidneys were harvested for histological injury scoring. Mean histopathology scores were 0.42±0.53 in group 1 (Sham), 2.97±0.21 in group 2 (Control), 2.68±0.15 in group 3 (Ketamine), 2.40±0.16 in group 4 (Propofol), and 2.51±0.22 in group 5 (Ketofol). The score in group 4 (Propofol) was significantly lower than those in groups 2 (control) and 3 (Ketamine) (P=.002 and P=.0120, respectively), but did not differ significantly from that in group 5 (Ketofol) (P=.347). The score in group 5 (Ketofol) was significantly lower compared to group 2 (control) (P=.006), but no significant difference was determined with Group 3 (Ketamine) (P=.137). No significant difference was also observed between Group 3 (Ketamine) and Group 2 (control) (P=.021). The study results indicated no superiority of ketofol over ketamine or propofol against renal IRI. However, the renal protective effect of propofol against IRI was greater than that of ketamine.
Predictive value of hounsfield unit in urinary system stones applied with eswl
Authors: Caglayan Alper , Horsanali Mustafa
Published: September 2022

This study claims to examine the relationship between the Housfield unit (HU) value and the success of Electro Shock Wave Lithotripsy (ESWL) treatment. Data of 142 patients were evaluated retrospectively in this cross-sectional observational study. The threshold value for stone density is calculated as 991.20 HU in the ROC analysis. The patients are seperated into two groups with respect to this value, and their demographic characteristics, stone characteristics and success rates after ESWL treatment are statistically compared. For the variables that are statistically crucial in the univariate analysis, logistic regression analysis are used as a multivariate analysis. The mean age of all patients were 45.25±11.72 years and the mean body mass index (BMI) is 28.42±3.98 kg/m2. While our stone-free rate was 66.2% in our study, the mean stone size was 11.25±3.83mm, the Hounsfield unit value was 1007.55±337.75 HU, and the stone-skin distance was 108.02±20.02mm, respectively. We observed a crucial difference in between the Housfield unit value and stone size in univariate and multivariate analyzes between the two groups, and the stone-free rate after ESWL. The Hounsfield unit value, measured by the non-contrast computed tomography method, is a parameter for the prediction in success of patients undergoing Electro Shock Wave Lithotripsy treatment. Also, stone density above 991.20 HU in patients having urinary system stone disease requires the evaluation of alternative treatments as a condition that reduces the success of the treatment.
Paratuberculosis control strategies in dairy cattle: A systematic review
Authors: pez Brahian , Valencia Nathalia , ndez Jos , Silva Jorge , squez Nicolas
Published: September 2022

Abstract
Background: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis (PTB), an incurable enterocolitis, affecting domestic and wild ruminants. Economic losses, impacts on animal health and welfare, and public health concerns, justify its herd-level control.
Aim: to systematically collect information to answer: What are the control and eradication strategies of PTB in dairy cattle worldwide?
Methods: the search procedure was carried out on October 2nd, 2019 and updated on August 3rd, 2021, using OVID®, SciELO, and Redalyc databases, and the registers from the International Colloquium on Paratuberculosis (1991-2018). The inclusion criteria considered articles published in English, Portuguese, and Spanish and in peer-reviewed journals. The exclusion criteria included irrelevant topics, species other-than bovines, and not original articles. Definitive studies were obtained through consensus of the authors on eligibility and quality. Data extraction was performed, considering bibliographic information, control and outcome strategies, follow-up time, and results.
Results: twenty-six relevant studies were found, reporting the use of three grouped control strategies: hygiene and management strategy (HMS), test-and-cull strategy (TCS), and vaccination strategy (VS). The HMS was the most common one (20/26), followed by TCS (17/26) and VS (7/26). Combined control strategies such as TCS-HMS (12/26), TCS-VS (1/26), and HMS-VS (1/26) were also described, and the consideration of the three control strategies (TCS-HMS-VS) was reported in two articles. The HMS included practices such as neonates/juvenile livestock hygiene, biosecurity, prevention of infection introduction into the herd, and environmental management. Within HMS, the most frequent practices were to remove calves from their dams as soon as possible after birth and to keep the minimal exposure of calves and heifers to adult cattle. As limitations, within the HMS it is considered that some strategies cannot be included due to lack of compliance, or the application of the same strategy among one study and another may have a different degree of interpretation; publication bias was not controlled since the results of the control programs in endemic countries may be not available.
Conclusion: the main PTB control strategies in dairy cattle worldwide are HMS, TCS, and VS. The use of one or several combined strategies has been found to succeed in controlling the disease at herd-level.
Implementasi Program Penyuluhan dan Demonstrasi Kesehatan Bagi Anak Usia Sekolah
Authors: Herwawan Joan Herly , Tomasoa Valensya Yeslin , Reunussa Mesy , Peny Petronela , Laurika Jein O , Rupidara Ake , Labok Stefani A , Kalay Vica C , Leatomu Delvin A , Telussa Yesi , Salaudin Jodi , Lekky Monalisa
Published: September 2022

Anak usia sekolah adalah anak yang berumur lebih dari 6 tahun sampai sebelum berusia 18 tahun atau anak dengan usia 7-15 tahun yang harus mengikuti wajib belajar 9 tahun atau yang terdaftar dan aktif bersekolah pada tingkat SD/sederajat hingga SLTP/sederajat. Anak usia sekolah merupakan sasaran yang ditargetkan dalam pelaksanaan program kesehatan, sebab jumlah anak sekolah sebesar 25% di antara jumlah penduduk. Beberapa masalah kesehatan yang dialami anak usia sekolah seperti ketidakseimbangan gizi, kesehatan gigi, kelainan refraksi, kecacingan terkait perilaku hidup bersih dan sehat. Negeri Mesa berpenduduk sebanyak 803 jiwa, dimana jumlah anak usia sekolah (5-14 tahun) adalah 170 jiwa. Berdasarkan hasil observasi dan wawancara didapatkan data adanya ketidaktahuan dan ketidakpedulian mengenai Perilaku Hidup Bersih dan Sehat (PHBS), serta ketidaktahuan mengenai dampak dari penggunaan gadget yang tidak sehat atau berlebihan. Berdasarkan masalah yang ada maka implemetnasi yang dilakukan terhadap anak usia sekolah adalah penyuluhan kesehatan tentang PHBS dan penggunaan gadget secara sehat, serta melakukan demonstrasi cara mencuci tangan dan menggosok gigi.
Evaluation of total polyphenols and antioxidant activity of African grape (Lannea macrocarpa) Fruits
Authors: S Muhammad , S Yahaya Lema
Published: September 2022

The aim of the research work is to evaluate the polyphenols and antioxidant activity of African grape fruits. The methanolic extract was evaluated for its phenolic contents using Folin-Ciocalteu reagent, antioxidant activity using 1, 1- diphenvi1-2 picrvlhidrazyl (DPPH) radical scavenging activity, and flavonoid using sodium nitrite solution. The total phenolic content was 380+2,11mg/100g gallic acid equivalent (GAE), antioxidant activity of 562.25 ± 2.91%, and flavonoids contents of 20.63 ± 1.80mg/100g quercetin equivalent (QE), The results indicated the importance of Lannea macrocarpa fruits as potential source of polyphenols which if property utilized could supplement the existing sources of antioxidants for the formulation of drugs and other therapeutic uses.
Rivelando la civiltà dell'Islam contemporaneo nei bambini in India
Authors: Nazmul Emon
Published: September 2022

Civiltà e cultura nel braccio del continente indiano ha avuto alti e bassi dall'era del colonialismo fino al giorno dell'indipendenza. Ciò può essere illustrato dal predominio della mappa politica che esisteva dall'arrivo delle nazioni straniere, in particolare dell'Inghilterra, fino al raggiungimento dell'indipendenza. La condizione della società indiana a quel tempo era piena di contraddizioni, conflitti religiosi, litigi, furti, razze diverse, alcuni interessi di gruppi dominanti, ecc. Da questa condizione sono derivate molte grandi figure politiche islamiche come Syeh Ahmad Sirhindi, Shah Waliyullah e la prossima generazione Sayyid Ahmad Khan e la prossima generazione della Lega musulmana indiana. Ciò che alla fine ha reso l'indipendenza dell'India e del Pakistan (1947 M) e quella del Bangladesh (1971 M). Quindi questi tre paesi, che sono gli stessi in termini di paesi storici, hanno anche vari miglioramenti dinamici e sofisticati dell'Islam.
PENDIDIKAN INKLUSI DI SEKOLAH DASAR ISLAM
Authors: Fadillah Ahmad Arif , Sulaiman Abdul Mugni Saudi , Ayumi Anis , Saharani Aura Luthfia , Putri Chika Meiliana , Nuraulia Dhea , Aziz Dhilla Shafirra , Najah Mia Alfiatun , Pertiwi Nabila Putri , Rizki Nabilla Oktaviani , Kamilatun Nur Ahya , Fadiniyah Qiromah
Published: September 2022

Education is a major milestone in supporting a person's success and success, which is obtained from early childhood until the person enters adolescence or adulthood. Inclusion education is an educational service that arranges for students who have disabilities, special needs or disabilities to be served at school together with their peers, without having to be assigned classes, where the student can carry out teaching and learning activities with other children normally with adequate accessibility. The application of inclusive education in Islamic elementary schools has a positive influence on children who have disabilities or special needs, so that they get the opportunity to be able to enjoy learning activities in schools as well as other children, where they are also a priority that must be considered without being discriminated against. This study discusses the role or importance of inclusion education applied in Islamic elementary schools. The results showed that inclusive education can be said to be effective and beneficial for children who have a special need or disability for the implementation of their rights in obtaining a fair and decent education so that they can become successful individuals in the future.
UPAYA MENINGKATKAN KEMAMPUAN MOTORIK HALUS DENGAN BERMAIN LEGO KONSTRUKTIF PADA ANAK KELOMPOK A PAUD RAUDATUL JANNAH DESA GENGGELANG KECAMATAN GANGGA
Authors: Alawiyah Tuti , Parhaini Lailatul
Published: September 2022

This study aims to improve fine motor skills by playing constructively with Lego for children in Group A of PAUD Raudatul Jannah, Genggelang Village, Gangga District, in the 2020/2021 Academic Year, aged 4-5 years, with a total of 14 children, namely 4 boys and 10 girls. The research method used is the Classroom Action Research Method, which is a research conducted systematically reflective of the various actions taken by the teacher to improve learning conditions. The data in this study were collected using observation methods, interview methods and documentation methods. The results of this study indicate that there is an increase in the fine motor skills of children in group A. In the pre-cycle the average value obtained was 41.2 with classical completeness of 21.4%. In the first cycle the fine motor skills of children increased with an average value of 59.9 and the percentage of classical completeness was 35.7% and in the second cycle the fine motor skills of children increased with an average value of 70 and the percentage of classical completeness reached 85.7%. This shows an increase in the percentage of fine motor skills as much as 64.3% from 21.4% to 85.7%, which means that fine motor skills are in the very well developed criteria with a percentage above 76% already achieved in this study. On average, children experience an increase in fine motor skills by playing constructive lego at PAUD Raudatul Jannah Gitak Demung, Genggelang Village, Gangga District, North Lombok Regency.
ANALYSIS OF REGIONAL REVENUE AND EXPENDITURE BUDGET PERFORMANCE BEFORE AND DURING THE COVID-19 PANDEMIC IN THE MAGELANG REGENCY GOVERNMENT FOR THE 2019-2020 PERIOD
Authors: Raissa Nadilla Amanda , Fatimah Ari Nurul
Published: September 2022

This study analyzes the Financial Performance of the Magelang Regency Government before the pandemic and during the COVID-19 pandemic by analyzing the level of regional independence, the effectiveness ratio of regional original income, the regional financial efficiency ratio, and the compatibility ratio. In this study, the data used is the Budget Realization Report for the 2019 and 2020 fiscal years. The method used in this research is to use quantitative descriptive which aims to explain information and descriptions of the development of financial performance as reflected in the Magelang Regency APBD before the pandemic and at the time of the pandemic occurs. Based on the research results, Magelang Regency regional financial independence ratio from 2019-2020 is classified as very low. Meanwhile, PAD effectiveness ratio of Magelang Regency from 2019 to 2002 shows good financial performance and is classified as very effective, followed by financial efficiency ratio in 2019 to 2020 shows an efficient performance. Thus, the Magelang district compatibility ratio from 2019 to 2020 has decreased, this is due to the diversion of the allocation of funds for handling COVID-19.
IMPAIRMENT IN VALUE OF PSAK 7 FINANCIAL ACCOUNTING STANDARDS, CLASSIFICATION OF ACCOUNTING MEASUREMENTS IN HEDGING COMPANIES IN THE BANKING SECTOR DUE TO CORONA VIRUS
Authors: Fery Irlan
Published: September 2022

The less difference between SAK and IFRS can provide benefits for stakeholders in commercial banks in Indonesia. Companies that have public accountability, regulators try to make the necessary regulatory infrastructure, especially in capital market transactions, as well as users of financial statement information can use or use financial accounting standards as a guide in improving the quality of information produced in financial statements. value, financial instruments, measurement classification, hedging in banking sector companies due to the corona virus. The results showed that the banking sector experienced a decline in value with the entry of the Corona Virus outbreak which lasted long enough so that the banking sector was depressed which resulted in the value of PSAK 71 changing the condition of banking financial statements so that risk hedges arise from certain risks that can affect profit and loss or comprehensive income. others, in the case of investments in equity instruments that the entity has selected to represent changes in fair value in other comprehensive income.
Modern educational environment
Authors: Franchuk N. P.
Published: September 2022

Research purpose is improvement of modern educational environment. The task of the research is to ascertain of urgent problems which require theoretical and experimental solution. A research object is the teaching process in higher education institution, the research subject is modern information-communication technologies. The result of the study is the educational process as balanced work of teachers and students during the combined organic and educationally prudent use of traditional and new facilities of teaching. Disclosed possibility of using cloud technologies in the educational process by the example of the course “Computer-oriented system of education of computer science and foreign language”.
Use of environment CoCalc and commercial systems and computer mathematics
Authors: Popel M. V. , Semerikov S. O. , Shokalyuk S. V.
Published: September 2022

The aim of this study is perform a comparative analysis and justify the expediency of the use in teaching CoCalc. Objectives of the study is compare Web-access to CoCalc and commercial SCM to analyze suitability for use in the educational process CoCalc and commercial systems SCM, the example of some commercial SCM (MathCAD and Maple) to consider the disadvantages of their use to reveal the contents of components CoCalc. The object of research is the process of using cloud environment CoCalc in pedagogical education institution. The subject of research is means of environment CoCalc. The paper considers the problem of the use of environment CoCalc and commercial of computer mathematics. The historical overview of the cloud environment are its basic components that can be used in the educational process teaching high school. A comparative analysis CoCalc and commercial SCM criteria for mobility, life learning, chargeless. Results of the study is the advantages of the use of cloud environment CoCalc in the learning process.
MarkHub Cloud Online Editor as a modern web-based book creation tool
Authors: Babenko Vitalina O. , Yatsenko Roman M. , Migunov Pavel D. , Salem Abdel-Badeeh M.
Published: September 2022

The main criterion for the competitiveness of a teacher or expert in the field of science is a good ability to present their knowledge to students in an interactive form without spending a lot of time in preparation. The purpose of the study is to analyze modern editors to create educational information content in the modern educational space and to present a modern tool for creating web books based on the latest IT technologies. Modern editors of web material creation have been analyzed, statistics of situations on mastering of knowledge by listeners, using interactive methods of information submission have been investigated. Using the WYSIWYG concept and analyzing modern information tools for presenting graphic material, an effective tool for teaching interactive web material was presented. An adapted version of the MarkHub online editor based on cloud technologies is presented. Using MarkHub cloud-based online editor for the unified development of educational content can significantly increase the author’s productivity in the content creation process. At the same time, the effects of reducing the time spent on formatting the external presentation of the content, making synchronous changes to different versions of the content, tracking the versions of the content, organizing remote teamwork in the network environment are achieved.
Formation of cognitive independence of students using Google services
Authors: Shustakova T. B.
Published: September 2022

Research goals: determine the impact of Google services on forming cognitive independence of students. Research objectives: analysis of existing methods of forming cognitive independence of students, analysis of Google services in education, the place and role of Google services on formation of cognitive independence of students, identify learning tool using Google services for the formation of cognitive independence of students. Object of research: forming cognitive independence of students in school I-III stages. Subject of research: use Google services for the formation of cognitive independence of students. Research methods used: analysis of scientific publications and personal experience. Results of the research. Based on psychological and pedagogical literature analyzed existing approaches to the formation of cognitive independence of students using the services of Google. The place and role of Google services on formation of cognitive independence of seniors. Defined learning tool using Google services for the formation of cognitive independence of students. The main conclusions and recommendations. Use the Google services forming cognitive independence high school students is appropriate and promising development in modern pedagogical practice.
Differentiation of student learning to complex analysis using CoCalc
Authors: Popel M. V. , Bobyliev D. Ye.
Published: September 2022

Research goals: to determine the ways of differentiation of future mathematics teacher learning to complex analysis using CoCalc. Research objectives: to analyze the problem of differentiating learning in pedagogical universities, particularly in process of teaching the professional disciplines; to determine the place of complex analysis in mathematical disciplines of pedagogical universities; to investigate the impact of CoCalc on differentiation of future mathematics teachers learning to complex analysis. Object of research: learning to complex analysis of future mathematics teachers at pedagogical universities. Subject of research: differentiation of student learning to complex analysis. Research methods used: analysis of scientific publications, observations, interviews with teachers. Results of the research. Based on the analysis of scientific works and interviews with teachers established that the problem of differentiating learning is very relevant during teaching of mathematical disciplines. Defined the place of complex analysis in mathematical disciplines. It’s shown that differentiated instruction is intended to include differentiated tasks in the learning. The specificity using CoCalc on “Complex function of complex variable” are described. The main conclusions and recommendations: 1) expedient use of differentiated tasks (which are distributed by different criteria) as a basic premise differentiation of education; 2) gradual complication of tasks with the gradual generalization of already learned material research and comprehension level.
CTE 2018 – How cloud technologies continues to transform education
Authors: Kiv Arnold E. , Soloviev Vladimir N. , Semerikov Serhiy O.
Published: September 2022

This is an introductory text to a collection of papers from the CTE 2018: The 6th Workshop on Cloud Technologies in Education, which was held in Kryvyi Rih, Ukraine, on the December 21, 2018. It consists of short introduction and some observations about the event and its future.
Model of using cloud-based environment in training databases of future IT specialists
Authors: Korotun Olha V. , Vakaliuk Tetiana A. , Soloviev Vladimir N.
Published: September 2022

The authors substantiates and develops the model of using cloud-based environment (CBE) in the training of databases of future information technology (IT) specialists, which consists of interrelated units: target (purpose, task of using CBE), conceptual (pedagogical approaches, didactic principles), organizational and semantic (characteristics of CBE, basic requirements for CBE, subjects of training, CBE of the teacher, CBE of the student, curricula of institution of higher education, educational-methodical complex of discipline “Databases”, installation and configuration of database management system, development of educational material from the database in electronic form, selection of cloudbased systems of distance learning, introduction of cloud-based systems of distance learning in the training of students’ databases, selection of CBE in database training (databases, forms, methods, tools), evaluative (criteria, indicators, levels of professional and practical competence of future IT specialists on the use of CBE in database training), effective (increased formation of the information and communication technologies of future IT specialists on the use of CBE in database training).
The technique of the use of Virtual Learning Environment in the process of organizing the future teachers’ terminological work by specialty
Authors: Pererva Victoria V. , Lavrentieva Olena O. , Lakomova Olena I. , Zavalniuk Olena S. , Tolmachev Stanislav T.
Published: September 2022

This paper studies the concept related to E-learning and the Virtual Learning Environment (VLE) and their role in organizing future teachers’ terminological work by specialty. It is shown the creation and use of the VLE is a promising approach in qualitative restructuring of future specialists’ vocation training, a suitable complement rather than a complete replacement of traditional learning. The concept of VLE has been disclosed; its structure has been presented as a set of components, such as: the Data-based component, the Communicationbased, the Management-and-Guiding ones, and the virtual environments. Some VLE’s potential contributions to the organization of terminological work of future biology teachers’ throughout a traditional classroom teaching, an independent work, and during the field practices has been considered. The content of professionally oriented e-courses “Botany with Basis of Geobotany” and “Latin. Botany Terminology” has been revealed; the ways of working with online definer (guide), with UkrBIN National Biodiversity Information Network, with mobile apps for determining the plant species, with digital virtual herbarium, with free software have been shown. The content of students’ activity in virtual biological laboratories and during virtual tours into natural environment has been demonstrated. The explanations about the potential of biological societies in social networks in view of students’ terminology work have been given. According to the results of empirical research, the expediency of using VLEs in the study of professional terminology by future biology teachers has been confirmed.
Educational digital games: models and implementation
Authors: Tokarieva Anastasiia V. , Volkova Nataliia P. , Harkusha Inesa V. , Soloviev Vladimir N.
Published: September 2022

Nowadays, social media, ICT, mobile technologies and applications are increasingly used as tools for communication, interaction, building up social skills and unique learning environments. One of the latest trends observed in education is an attempt to streamline the learning process by applying educational digital games. Despite numerous research data, that confirms the positive effects of digital games, their integration into formal educational contexts is still relatively low. The purpose of this article is to analyze, discuss and conclude what is necessary to start using games as an instructional tool in formal education. In order to achieve this aim, a complex of qualitative research methods, including semi-structured expert interviews was applied. As the result, the potential of educational digital games to give a unique and safe learning environment with a wide spectrum of build-in assistive features, be efficient in specific training contexts, help memorize studied material and incorporate different learning styles, as well as to be individually adaptable, was determined. At the same time, the need for complex approach affecting the administration, IT departments, educators, students, parents, a strong skill set and a wide spectrum of different roles and tasks a teacher carries out in a digital game-based learning class were outlined. In conclusion and as a vector for further research, the organization of Education Design Laboratory as an integral part of a contemporary educational institution was proposed.
Technology of forming media literacy of children of the senior preschool age of Ukraine
Authors: Yankovych Oleksandra I. , Chaika Volodymyr M. , Ivanova Tetiana V. , Binytska Kateryna M. , Kuzma Iryna I. , Pysarchuk Oksana T. , Falfushynska Halina I.
Published: September 2022

The article substantiates the technology of forming media literacy of senior preschool children in the establishments of preschool education of Ukraine.The features of preschool media education have been determined. Its relevance has been shown. The focus is on conducting the all-Ukrainian experiment on media education for 2017–2022.The problems in implementation of media education in preschool establishments have been identified and the prospects for their solution have been determined. The psychological factors of forming media literacy of children of the senior preschool age have been highlighted. It has been proved that preschool age is sensitive for the formation of critical thinking. The concept of “preschool media education” as part of the educational process has been characterized by the three-component structure.The peculiarities of conducting ascertaining and forming experiments in the establishments of preschool education of Ternopil, Khmelnytskyi have been shown. The expediency of media education for educators of the establishments of preschool education of Ukraine has been proved.
The areas of educational studies of the cloud-based learning systems
Authors: Popel Maiia V. , Shyshkina Mariya P.
Published: September 2022

The article analyzes the current stage of educational studies of the cloud-based learning systems. The relationship between the notions of the cloud-based learning system and the cloud-based learning environment are investigated. It was found that the researchers paid most attention to the design of a cloud-based learning environment. However, in the process of a cloud-based environment design, the researchers consider a cloud-based system as a component within the cloud-based learning environment of as a stage in the process of design. It is shown that in the research literature there is no single interpretation of the concept of a cloud-based system for educational purposes. Still the number of basic approaches to the interpretation of the concept under investigation are revealed. The first approach is based on the understanding of the system, as a set of cloud services or cloud-based technologies. The second approach is to consider a separate cloud service as a cloud-based learning system. In this case, the cloud service tools should include such components that cover the content, the tools, the forms and the methods of learning. The structure of the cloud-based learning system within the interpretation of the latest works of Ukrainian researchers is considered.
Moodle course in teaching English language for specific purposes for masters in mechanical engineering
Authors: Shalatska Hanna M. , Zotova-Sadylo Olena Yu. , Muzyka Ivan O.
Published: September 2022

The central thesis of this paper is that e-learning courses can have a significant impact on English language for specific purposes (ESP) proficiency of mining mechanical engineering students. The purpose of this study is to assess the effectiveness of ESP Moodle-based course “English for Mining Mechanical Engineers” and to reveal the results of its experimental approbation. In order to identify the lectures’ and learners’ needs we have applied the survey research. The survey confirmed the greatest demand for Moodle courses that include all the elements of a coherent training manual to provide self-development of engineering students. The interview results contributed to design of author’s ESP course syllabus. The importance and originality of this study are that to approbate the course materials’ effectiveness two approaches have been adopted simultaneously. The first is blended learning method based on e-learning platform applied in the experimental group and the second one is classic in-class instructor-led studying used in a control group. Students’ progress in ESP proficiency has been assessed using the cross assessment method. The experiment has validated the initial hypothesis that the special online courses focused on honing foreign language skills and integrated in the domain of specific professional knowledge have a beneficial effect on students’ communicative competencies in general. There were identified the advantages of self-tuition based on Moodle platform. The Moodle course lets the teachers save considerable in-class time to focus more on communicative assignments. The findings of this study have a number of practical implications in ESP online courses development.
Systematicity of students’ independent work in cloud learning environment
Authors: Kolgatin Oleksandr H. , Kolgatina Larisa S. , Ponomareva Nadiia S. , Shmeltser Ekaterina O.
Published: September 2022

The paper deals with the problem of out-of-class students’ independent work in information and communication learning environment based on cloud technologies. Results of appropriate survey among students of pedagogical university are discussed. The students answered the questions about systematicity of their learning activity and propositions for its improving. It is determined that the leading problems are needs in more careful instruction according to features of the task completing, insufficient experience in self-management, the lack of internal motivation. Most of all, students recommend to provide the tasks with detail instruction (oral or written) and to pay attention to careful planning the time that is necessary for full completion of the task. It is pointed that such complicated requirements can be satisfied only by complex use of information and communication technologies as well as the automated system of pedagogical diagnostics. Some requirements for management of students’ out-of-classroom independent work are formulated as a result of this discussion.
Centralized information web-oriented educational environment of Ukraine
Authors: Shapovalov Viktor B. , Shapovalov Yevhenii B. , Bilyk Zhanna I. , Atamas Artem I. , Tarasenko Roman A. , Tron Vitaliy V.
Published: September 2022

The modern development of science and technology has provided high quantity of information. This information must be systemized and classified. For taxonomization of educational materials, it was proposed to use existing graph-generators and graph-visualizers of the TODOS IT platform. A separate aspect of the TODOS IT platform is the possibility of using a centralized web-oriented learning environment. Creation of the system and transdisciplinary knowledge is a problem of modern education, which can be solved by creating a centralized web-oriented educational environment. Using this approach is an important part of the learning process. Such a centralized web-oriented environment based on the ontological approach involves filling, adaptive educational services with information resources that reflect the conceptual system of a particular discipline.One of the systems providing not only collection of information but include its systemizing is centralized web-oriented educational environment based on Ontology4 system. Ontology 4 use elements of the TODOS.The paper presents specific developments of one centralized web-oriented educational environment can be used to teach different subjects such as biology, chemistry, Ukrainian language and literature, using the STEM approach.
A REVIEW OF GREEN SOLVENT IONIC LIQUIDS: AS A FUTURE SOLVENT
Authors: Tomar Parul , Jain Deepali
Published: September 2022

Currently, chemists seem more fascinated with exploiting less hazardous green solvent ionic liquids for countering the detrimental consequence of organic solvents on the environment. Ordinarily, ionic liquids having salt-like structures comprise cations and anions. Ionic liquids alleviate various enzyme-catalyzed reactions having excellent yields, increasing capacities and functions, enhancing recyclability, increasing stability, recovery, and cost-effectiveness, and these are cardinal elements for applications in industry. Furthermore, growing nanotechnology, polymer, electrochemistry, environmental chemistry, pharmaceutical medicinal chemistry or pharmaceutical chemistry, and biochemistry in the area of ionic liquids have been flourished among investigators. Ionic liquids-supported materials and techniques are excellent for efficient and sustainable procedures. Because of their assignment as designer solvents, through which the physiochemical dimensions of an Ionic liquid can be adjusted for better functioning for peculiar applications. The review delivers the gradual improvement, growth or development, or progress and prospects of ionic liquids and their physicochemical properties as well as examples of applications in a unified fashion.
IN-VITRO ANTIDIABETIC ACTIVITY OF STANDARDIZED ACAIBERRY EXTRACT
Authors: Pallerla Praneetha , Posani Harshitha
Published: September 2022

In the present study, the standardized Acaiberry extract was studied for in-vitro antidiabetic activity. The aim of this work was to evaluate the inhibitory activities of the methanolic extract of standardized Euterpe oleracea (Acai berry) of family Arecaceae, at different concentrations. Diabetes is a severe, metabolic disorder characterized by increased levels of glucose that circulates in the blood plasma. Alpha amylase and alpha glucosidase inhibitors are used to achieve greater control over hyperglycemia in type 2 diabetes mellitus. The present study intends to screen alpha amylase and alpha glucosidase inhibitors from natural sources like plants in order to minimize the toxicity and side effects of the inhibitors currently used to control hyperglycemia. The acaiberry extract exhibited significant α-amylase and α-glucosidase inhibitory activities with IC50 value 6.29 mg/ml and 7.03 mg/ml respectively and well compared with standard Acarbose for alpha (α)-amylase and alpha (α)-glucosidase inhibitory activities respectively.
SYNTHESIS, SPECTRAL AND MAGNETIC SUSCEPTIBILITY STUDIES OF 1,8,15,22- TETRAIODOPHTHALOCYANINE COMPLEXES OF COBALT, NICKEL, COPPER AND ZINC
Authors: Somashekarappa M P , Keshavayya J
Published: September 2022

Some 1,8,15,22-tetraiodophthalocyanine complexes of cobalt (3-ICoPc), nickel (3-INiPc), copper (3-ICuPc) and zinc (3- IZnPc) were synthesized from the corresponding tetraamino substituted metal phthalocyanine complexes using modified Sandmayer’s method. The corresponding 1,8,15,22-tetranitrophthalocyanine complexes of the metals were used as precursors for the synthesis of 1,8,15,22-tetraamino substituted metal phthalocyanines. 1,8,15,22- tetranitrophthalocyanine complexes were in turn synthesized from reaction between 3-nitrophthalic acid with corresponding metal salts. The characterization of bluish green colored complexes was done by elemental analyses, Uvvisible and IR spectroscopy, and magnetic susceptibility measurements in order to check their purity and structural integrity. Measurement of magnetic susceptibility with varying magnetic field strengths revealed that, the magnetic moments are higher than the spin only values and shows the presence of intermolecular cooperative effects.
EVALUATION OF ANTI-GASTRIC ULCER ACTIVITY OF THE FRUIT EXTRACTS OF TERMINALIA BELLERICA ROXB IN EXPERIMENTAL RODENTS
Authors: Mishra Shikha , Gupta Ruchi , Shrivastava Arpit , Shrivastava Megha , Modi Mahak
Published: September 2022

Terminalia bellirica Roxb (T. bellirica, Combretaceae), known as Bahera or Beleric or bastard myrobalan is a large deciduous tree common on plains and lower hills in Southeast Asia, where it is also grown as an avenue tree. Glycoside, tannins, gallic acid, ellagic acid, ethyl galate, gallyl glucose, chebulanic acid are the main active phytoconstituents of medicinal importance. These phytoconstituents are responsible for many of the pharmacological roles. Different parts of the tree have various medicinal activities. In the present study, ethyl acetate and ethanolic extract of T. bellirica fruits, at the doses of 250 and 500mg/kg was evaluated for the anti-gastric ulcer activity using experimental gastric ulcer models induced by ethanol and aspirin. The phytochemical screening revealed the presence of triterpenoids, saponins, phenolic compounds, tannins, flavonoids, carbohydrate and glycosides. The parameters taken to assess anti-gastric ulcer activity were volume of gastric secretion, pH, free acidity, total acidity, ulcer index and histopathological studies of the stomach epithelium. The results indicate that the ethanolic and ethyl acetate extract of T. bellirica fruits produced a dosedependent reduction of the volume of gastric acid secretion, pH, free acidity, total acidity and ulcer index with respect to standard (Omeprazole 20mg/kg) used in the present study. The findings therefore indicate that ethyl acetate and ethanol extract possess anti-gastric ulcer activities in experimental animals induced by alcohol and aspirin, which might be due to presence of phenolic compound and flavonoids whose presence, was confirmed by phytochemical analysis. Therefore, this study validates its anti-gastric ulcer use in Indian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed.
ISOLATION AND SCREENING OF ACTINOBACTERIAL ISOLATES FROM CHEMICAL PESTICIDES USAGE FIELDS OFTHE UTTARAKHAND REGION
Authors: Rani Ankita , Mathur Abhishek , Gupta Sanjay
Published: September 2022

The excessive use of pesticides causesmaximum soil stress and infertile conditions. The present study was performed in order to explore and identify the novel microbial source for the biodegradation of monocrotophos pesticides. Soil samples (approx. 500 g) were collected using some clean,dry, and sterile polythene bags along with a sterile spatula, marking pen rubber band, and other accessories. These samples were air-dried for 1 week, crushed, and sieved. The sieved soils were then used for Actinomycetes isolation. A totalof 120 Soil samples were aseptically collected from different field regions of Uttarakhand viz. Tehri-Garhwal, Chamoli, Srinagar, Uttarkashi, and Haridwar havedominant usage of monocrotophos pesticides. Amongst these samples, A total of 280 microbes were isolated; out of which 24 isolates of Actinobacteria (8.57 %) were isolated. The results revealed the strains of the genera viz. Micromonospora (65%), Actinomycetes (25%,) and Streptomyces (10%)are meant to be responsible for the biodegradation of monocrotophos pesticides.
EFFECT OF NANONIZED CHRYSIN ON FEXOFENADINE PHARMACOKINETICS MEDIATED BY P-GLYCOPROTEIN IN RATS
Authors: Sashidhar R B , Dhurke Rajeshre , Alikatte Kankalatha
Published: September 2022

Chrysin(CHR) is an abundant flavonoid in nature and has been found to possess P-glycoprotein (P-gp) inhibition activity in vitro, which may have the potential to alter bioavailability of P-gp substrates. The main objective of this study was to investigate the effect of nanonized chrysin (NCH) on the intestinal absorption and pharmacokinetics of P-gp probe substrate; fexofenadine in rats. NCH was prepared by antisolvent precipitation method and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and in vitro dissolution testing. The influence of CHR and NCH on fexofenadine intestinal transport and permeability were evaluated by in vitro non-everted sac and in situ single pass intestinal perfusion (SPIP) studies. These findings were further confirmed by an in vivo pharmacokinetic study in which fexofenadine was administered (10 mg/kg, p.o) to CHR and NCH (50 mg/kg, p.o.) pretreated (10 days) rats and its plasma concentrations were determined by HPLC analysis. The intestinal transport and apparent permeability (Papp) of fexofenadine were significantly increased in duodenum, jejunum and ileum of CHR and NCH pretreated group as compared with the control. Similarly effective permeability (Peff) of fexofenadine was increased significantly in ileum of CHR and NCH pretreated group as compared with control. Cmax, AUC0-t and AUC0- ∞ of fexofenadine were found to be increased in CHR and NCH pretreated groups. Further, the CL/F and Vd/F of fexofenadine were significantly decreased. NCH enhances the oral bioavailability of fexofenadine by inhibition of P-gp mediated drug efflux during the intestinal absorption.
FLUORESCENT STUDIES OF LYSOZYME IMMOBILISED CHITOSAN/POLYSTYRENE SULPHONATE MULTILAYER MEMBRANES
Authors: Mathew Jissy , Usha K
Published: September 2022

The fluorescence emission properties of lysozyme immobilized at selected pH 5, 8.8 and 10.6 on chitosan/polystyrene sulfonate (CHI/PSS) multilayer membranes were investigated. The tryptophanyl fluorescence was selectively excited at 290 nm. The emission maximum and fluorescence intensity were found to be dependent on the pH of lysozyme solution. The fluorescence intensity was highest at pH 8.8. A slight red shift was observed as the pH changes from 5 to 10.6. Quenching of lysozyme fluorescence by iodide was used to study the effect of pH on the adsorption pattern of lysozyme to multilayers. For lysozyme (pH 10.6) adsorbed membrane, the fluorescence intensity was found to decrease progressively with quencher concentration. Almost complete quenching of fluorescence was observed when the iodide concentration was 1 M suggesting full accessibility of quencher to tryptophanyl residues. A linear Perrin plot was obtained suggesting a static mechanism for quenching under the experimental conditions. Fluorescence quenching studies were also carried out with lysozyme (pH 5) adsorbed membranes prepared by normal adsorption methods and also under ultrafiltration conditions. The quenching efficiency was different for the two sets of membranes. The fluorescence quenching studies reveals that adsorption pattern of proteins on multilayers strongly depend on pH and immobilization method.