bluuebunny/crossref_metadata_2025 huggingface dataset:
Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report
Authors: Agarwal Nitish , Verma Satish Kumar , Gopinathan Vikram Raj , Sharma Mehar Chand , Sharma Anima , Chandra Sarat P.
Published: August 2024

Pituitary carcinoma is a rare entity comprising 0.1–0.2% of all pituitary tumors and presents significant diagnostic and therapeutic challenges. Intraspinal drop metastasis in these tumors is even rarer. We report a case of a prolactin secreting pituitary carcinoma with intracranial metastasis and multiple intraspinal drop metastasis. This is the first case where 68Gallium labelled [1,4,7,10 – tetraazacyclododecane – 1,4,7,10 – tetraacetic acid] -1- NaI3 - octreotide (68Ga-DOTANOC) whole-body positron emission tomography–computed tomography (PET-CT) has been used in a case of malignant prolactinoma, in an attempt to ascertain the somatostatin receptor (SSTR) expression on tumor cells. Through this paper, we suggest that SSTR targeted radionuclide therapy could have a potential role in aggressive pituitary tumors and pituitary carcinomas similar to the promising role of lutetium-labelled peptides in inoperable or metastasized gastroentero-pancreatic neuroendocrine tumors (GEP-NETs).
Multiple ASM Administration via Percutaneous Feeding Tube as a Cause of Pseudo-Refractoriness Leading to Recurrent Seizure Clusters
Authors: Ambarapu Swetha , Chaudhari Rima
Published: August 2024

It is important to identify true refractoriness of seizures, before escalation of anti-seizure medications, to avoid side effects of medications. Bioavailability of medications changes with the formulations used and changes significantly with the route of administration. Both of these were significantly impacted in a lady who was being fed via percutaneous endoscopic gastrostomy (PEG) feeds and deemed refractory to medications. After altering the formulations and the method, she became seizure-free.
Which Acute Stroke Patients can Walk while Returning Home? Factors Predicting Ambulation
Authors: Zeynep Kirac Unal , Damla Cankurtaran , Ebru Umay
Published: August 2024

Purpose:

Regaining gait is the primary goal in stroke rehabilitation. In this study, we aimed to investigate the effect of premorbid features of acute stroke patients on the ambulatory level.

Methods:

The study included 174 patients who applied to our rehabilitation clinic within the first month after the onset of stroke. Demographic characteristics of patients, pre-stroke symptoms, and stroke characteristics were questioned from patient files and historical data. The ambulation levels of patients before and after rehabilitation were evaluated with the functional ambulation category. The relationship between demographic characteristics, pre-stroke symptoms, stroke characteristics, and ambulation levels of patients before and after rehabilitation was examined.

Results:

The presence of coronary heart diseases, atrial fibrillation, and nausea/vomiting before stroke were independent negative risk factors on both pre- and post-rehabilitation ambulation levels (P < 0.05). Additionally, advanced age, oxygen, and mechanical ventilation requirement were other negative independent risk factors on post-rehabilitation ambulation levels (P < 0.05).

Conclusions:

Knowing some of the pre-stroke characteristics of patients while applying rehabilitation programs may be useful in estimating the ambulatory levels on returning home.
A Radiomics Model for the Differentiation of Intracranial Solitary Fibrous Tumor/Hemangiopericytoma and Meningioma Based on Multiparametric Magnetic Resonance Imaging
Authors: Xiong Hua , Yin Ping , Luo Weiqiang , Li Yihui , Wang Sicong
Published: August 2024

Background:

Although the imaging findings of intracranial solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) and meningioma are similar, their treatment and prognosis are quite different. Accurate preoperative identification of these two types of tumors is crucial for individualized treatment.

Objective:

The aim of this study was to develop a radiomics model for the differentiation of intracranial SFT/HPC and meningioma based on multiparametric magnetic resonance imaging (mpMRI).

Material and Methods:

A total of 99 patients from July 2012 to July 2018 with histologically and immunohistochemically confirmed SFT/HPC (n = 40) or meningiomas (n = 59) were retrospectively analyzed. A total of 1118 features were extracted based on its image shape, intensity and texture features. The logistic regression (LR) and multi-layer artificial neural network (ANN) classifiers were used to classify SFT/HPC and meningioma. The predictive performance was calculated using receiver operating characteristic curves (ROC).

Results:

We found significant difference in terms of sex between the SFT/HPC and meningioma group (χ
2
= 4.829, P < 0.05), but no significant difference was found in age (P > 0.05). The most significant radiomics features included five shape and four first-order level features. For the LR classifier, the prediction accuracy of SFT/HPC was 71.0% and meningioma was 78.7%. For the ANN classifier, the prediction accuracy of SFT/HPC was 83.9% and meningioma was 80.9%. Both of the two classifiers achieved a high accuracy rate, but ANN was better.

Conclusions:

Radiomics features, especially when combined with an ANN classifier, can provide satisfactory performance in distinguishing SFT/HPC and meningioma.
A Prospective Study on Perfusion MRI Changes in Intracranial Meningiomas Following Gamma Knife Therapy
Authors: Singh Bhoopendra , Agrawal Deepak , Garg Ajay , Singh Manmohan , Chandra P S , Kale Shashank S
Published: August 2024

Background:

Radiosurgery plays an important role as a treatment modality for intracranial meningiomas. Perfusion MR imaging can be performed by using arterial spin-labeling (ASL) which is a relatively new and advanced technique.

Objectives:

To assess the changes in perfusion parameters on ASL perfusion MRI in intracranial meningioma after radiosurgery and correlate with histopathological grade of meningioma.

Materials and Methods:

In this Prospective study done at the our institute over a period of 20 months (Jan 2016–Aug 2017), patients with intracranial meningiomas had perfusion MRI with ASL sequence on GE Optima 450W®, 1.5T MRI (GE Medical Systems) prior to GKT and at 6 months after GKT were included in the study.

Results:

Twenty-seven patients were included in this study. Mean cerebral blood flow (CBF) was higher in angiomatous meningiomas. Though mean values of average CBF, maximum, minimum, and SD derived from the ASL MR perfusion were relatively higher in post GKT group as compared to those obtained in pre-GKT but it was not clinically significant. Mean baseline volume of whole cohort was 5.71 cm3 and decreased significantly post GKT in a follow up of 6 months to 5.59 cm3 (P value 0.0018). On comparing volumes of primary and secondary group, volumes were not found be significantly decreased in primary group (P value = 0.1361), 0.1361), but significantly reduced in secondary group (7.13 vs 7.034 cm3) (P value of = 0.0038).

Conclusion:

Our preliminary observations support ASL as a sensitive MRI sequence for the evaluation of meningioma perfusion patterns.
Posterior Fossa Craniopharyngioma Arising from the Inferior Medullary Velum
Authors: Raju Dimble , Mukherjee Chandramouli , Das Sayan , Sanyal Sugat , Krishnan Prasad
Published: August 2024

We report the case of a 63-year-old man with a midline posterior fossa tumor and peculiar imaging features where we were unsure of the nature of the lesion preoperatively. Histopathology revealed it to be a craniopharyngioma. It appeared to arise from the inferior medullary velum, a site not described before in the literature. The previous four cases mentioned in literature and speculations on the origins in this uncommon site are discussed.
Morphometric Study of the Intracranial Fluid Spaces in Schizophrenia
Authors: Ozdikici Mete
Published: August 2024

Background:

The intracranial fluid spaces (IFS), also known as “the extra-axial spaces,” consist of the superficial cerebral sulci, the Sylvian fissures, the basal cisterns, the third ventricle, the fourth ventricle, and the two lateral ventricles. In diseases such as schizophrenia, Alzheimer’s, Parkinson’s, and especially hydrocephalus, IFS’ enlargements are observed.

Objective:

Our study aimed to determine the mean values of IFS measurements in patients with schizophrenia and compare them with healthy controls.

Material and Methods:

This work has been carried out on 188 cases, out of which 88 schizophrenia patients (56 men and 32 women) met the diagnostic criteria according to DSM-5 for schizophrenia and 100 healthy controls (50 men and 50 women). The 10 parameters have been used to evaluate IFS on magnetic resonance imaging (MRI) scans.

Results:

The parameters showing statistically significant differences were higher in favor of the individual with schizophrenia. Except for the bifrontal index and Evan’s index, most parameters (the bicaudate index, the fourth ventricle width, the fourth ventricle index, the maximum width of the anterior interhemispheric fissure, the maximum width of the right frontal subarachnoid space, the maximum width of the left frontal subarachnoid space, the maximum width of the right Sylvian fissure, and the maximum width of the left Sylvian fissure) were obtained statistically highly significant differences between the examined and control groups.

Conclusions:

In schizophrenia, it is more practical to evaluate brain atrophy using some parameters, especially the width of the Sylvian fissure and the bicaudate index.
Burden of Noise-Induced Hearing Loss among Rice Mill Workers in Sokoto State, Northwest Nigeria
Authors: Azees Ayotunde S. , Ango Jessica T. , Isa Abdulfattah , Adeniyi Makinde A.
Published: August 2024

Context:

Work heavily impacts workers' health globally, with noise-induced hearing loss (NIHL) increasingly becoming a major public health concern.

Aim:

This study accessed the prevalence and predictors of noise-induced hearing impairment among local rice mill workers in Sokoto State, Northwest Nigeria.

Materials and Methods:

This cross-sectional study was conducted among rice mill workers between June 2019 and July 2019. Participants were selected using a multistage sampling technique, and a pretested interviewer-administered questionnaire was used for data collection. Data were analyzed using IBM® Statistical Package for the Social Sciences (SPSS) version 22, and the results were presented in tables and figures. Statistical tests of associations were conducted using the Chi-square test and binary logistic regression with a significance level set at P < 0.05.

Results:

The noise level in the rice mills ranged from 81.8 dBA to 91.7 dBA, with a mean of 86.7 ± 2.3 dBA. A hundred and eighty-five respondents (46.5%) of the 398 respondents had at least a symptom of hearing loss, with tinnitus (145 (36.4%)) being the most prevalent. About a third of 125 (32.5%) had hearing impairment in at least one of the ears on audiometry. The predictors of hearing impairment on audiometry were cigarette smoking, education, and having symptoms of hearing loss.

Conclusion:

The burden of noise-induced hearing impairment is high among rice mill workers in Sokoto State, Northwest Nigeria; hence, both the government and rice mill owners need to initiate smoking cessation programs, promote the use of personal protective equipment, and urgently implement hearing conservation programs to address the problem.
Role of A Body Shape Index (ABSI) in Clinical and Public Health Practices: A Correlational Study on Igbo Adults, Southeast Nigeria
Authors: Obaje Sunday G. , Sonia-Love Okorie , Egwu Oguguo A.
Published: August 2024

Context:

The role of A Body Shape Index (ABSI) has gained attention in both clinical and public health realms due to its potential in predicting health outcomes. This study focuses on Igbo adults in Southeast Nigeria, a population with limited ABSI-related research.

Aim:

It focuses solely on the relationship between ABSI and blood pressure for a healthy living in Nigeria. Research Settings and

Design:

The study enrolled 200 Igbo adults aged 18–25 years. Measurements including height, weight, waist circumference, and blood pressure were collected using measuring tapes, weighing scales, and blood pressure monitors. Statistical analysis employed SPSS version 20, with a significance level of P < 0.05.

Results:

The mean ABSI remained consistent across various age groups and genders. An explicit positive correlation between age and ABSI was observed. Despite a low area under the curve (AUC) of 0.450 in receiver operating characteristic (ROC) analysis, ABSI exhibited optimal predictive capability with a specificity of 77.00% and sensitivity of 35.7%.

Conclusion:

ABSI emerges as a newer and promising alternative index for blood pressure predictions. Its incorporation in clinical and public health practices can enhance disease predictability. This study provides critical insights into the applicability of ABSI within the Igbo population and underscores its potential utility in broader healthcare contexts.
Incidence, Timing, and Possible Risk Factors for Post-Cesarean Wound Infection among Low-Risk Patients in Zaria, Nigeria: A Cross-Sectional Study
Authors: Zubairu Usman D. , Abdul Muhammad A. , Bawa Umma S. , Madugu Nana H. , Ghazzali Sakina
Published: August 2024

Context:

Rising cesarean section rates worldwide have led to an increase in post-operative complications, especially wound infection, and endometritis. Low-risk cesarean sections are still at risk of these infections despite the absence of common risk factors. The burden and possible risk factors for these have not been widely documented in patients without major risk factors.

Aim:

To determine the incidence, timing of diagnosis, and possible risk factors for wound infection in low-risk cesarean sections.

Settings and Design:

A prospective cross-sectional study conducted among consenting women undergoing low-risk cesarean sections, defined as the absence of established risk factors for post-operative wound infection.

Materials and Methods:

Participants' sociodemographic and obstetric characteristics were documented in a structured proforma. The primary outcome measure was the incidence and timing of wound infection. Secondary outcome measures were the incidences of endometritis and febrile morbidity. The data were analyzed using SPSS version 21 and Windows WINPEPI.

Results:

The incidence of wound infection was 11.2% (19); endometritis—20.6% (35); febrile morbidity—4.1% (7). The mean timing of diagnosis of wound infection and endometritis were 10.22 ± 3.64 and 11.57 ± 3.34 days, respectively. Grandmultiparity (P = 0.007), low maternal educational levels (P = 0.014), endometritis (p = <0.0001), and febrile morbidity (P = 0.017) were the demonstrated risk factors for wound infection.

Conclusion:

The incidence of wound infection in the study population was high and mostly diagnosed after discharge from the hospital. Risk factors for wound infection were grand multiparity, lower educational level, endometritis, and febrile morbidity.
Comparison of Transperineal Ultrasound Cervical Length and Fetal Head- Perineum Distance Measurements with a Simplified Bishop Score in Predicting Induction of Labor Outcome: What is new?
Authors: Usman Mohammed , Adekunle Oguntayo O , Umma S Bawa , Iliyasu Abbas , Joseph B. Igashi
Published: August 2024

Context:

The goal of Induction of labor (IOL) is to achieve vaginal delivery and reduce cesarean section. The Bishop score (BS) is the gold standard method to assess cervical status, but it is not flawless, leading to unnecessary interventions. Transperineal ultrasound measurements have been compared with the BS in predicting successful IOL. Yet the results are inconsistent.

Aim:

This study aimed to compare transperineal ultrasound measurements and a simplified BS in predicting IOL outcomes at Ahmadu Bello University Teaching Hospital (ABUTH) Zaria.

Settings and Design:

This was a cross-sectional comparative observational study conducted at the labor wards of ABUTH.

Materials and Methods:

It was conducted among women for IOL at 37–42 weeks between June 2019 and February 2020. Ninety-Seven women were recruited. Each woman, had a transperineal ultrasound cervical length (TPUS-CL) and fetal head perineum distance (FHPD) measured. This was followed by a simplified BS assessment.

Statistical Analysis Used:

Relevant Data obtained was entered and analyzed using SPSS version 23. The significance level was considered at P < 0.05.

Results:

The diagnostic accuracy of TPUS-CL (area under the curve (AUC) =0.604, P = 0.084) was better than the simplified BS (AUC = 0.551, P = 0.402). FHPD (P = 0.067, CI = 0.983–1.661) was superior to fetal station (P = 0.832, CI = 0.599–1.890) in predicting the outcome of IOL. The favorable cut-off values for TPUS-CL, FHPD, and BS in our study were ≤ 3 cm, ≤5 cm, and 5 respectively. It demonstrated that TPUS-CL (P = 0.005, AUC = O.750) and FHPD (P = 0.017, AUC = 0.711) are better than simplified BS in predicting success among Primigravidas.

Conclusion:

TPUS-CL and FHPD measurements are better than the simplified BS in predicting IOL outcome in primigravidae.
Clozapine-Induced Somnambulism in a 55-year-old Lady with Psychotic Depression: A Case Report
Authors: Gudaji Mustapha Ibrahim , Habib Zahraddeen Garba , Abubakar Zakiyya Sadiq
Published: August 2024

Sleep walking disorder or somnambulism is a parasomnia that occurs in non-rapid eye movement sleep (NREM) characterized by an individual arising from bed and ambulating without fully awakening. It is known to be associated with multiple medications and has been reported with atypical antipsychotics. Here, we report a case of sleep walking induced by clozapine; before this, there have only been two reported cases of clozapine induced somnambulism.
Wax-Induced Episodic Hemolysis in a Patient with Co-Inheritance of Sickle Cell Anemia and G6PD Deficiency
Authors: Baba Abdulwahab I. , Yusuf Aminu A. , Gwarzo Dalha H. , Idris Ibrahim M.
Published: August 2024

Both sickle cell anemia (SCA) and glucose-6-phosphate dehydrogenase (G6PD) deficiency are common genetically transmitted disorders associated with hemolytic anemia, with a high prevalence in sub-Saharan Africa. Co-inheritance of both diseases has been reported in Nigeria where the prevalence of each disease is high. However, a high index of suspicion is needed to diagnose the co-existence of both disorders in the same individual. Here, we present an unusual case of a 32-year-old dentistry student who was known to have SCA since the age of one year. He presented with episodic exacerbation of jaundice and passage of dark-colored urine following skin and inhalational exposure to wax (polycyclic aromatic hydrocarbons) used for reconstructive dental practical sessions. After investigations, he was found to have G6PD deficiency. This report underscores the importance of screening for G6PD deficiency in male patients with SCA presenting with episodic symptoms of hemolysis.
Application of Maggot Debridement Therapy on Infected Wounds of Newborns: A Case Series in Iran
Authors: Motallemzadeh Sajjad , Tabaie Seyed Mehdi , Mirzaei Jamal , Akbarzadeh Kamran , Djavid Gholamreza Esmaeeli , Sabo Yusuf Mohammad , Yusuf Mustapha Ahmed , Malekian Azam
Published: August 2024

Neonates hospitalized in the Neonatal Intensive Care Units (NICU) are exposed to a higher risk of iatrogenic skin lesions. Maggot Debridement Therapy (MDT) in recent years has gotten more attention as a debriding, and disinfecting agent. The aim of this study was to treat infants with infected wounds and to evaluate the effectiveness and safety of MDT on in this group of patients. The study was conducted on four infants (12 to 30 days old) with infected wounds who could not withstand surgical debridement. Lucilia sericata larvae were used along with other standard therapies. The result of this study showed that MDT is an effective biological debridement tool with a good safety margin amongst infants. It removes all the necrotic tissue and induced granulation after application. In addition, it shortens the healing time, reduced pain, and decreased the rate of antibiotic consumption thereby reducing the overall cost of management.
Knowledge and Perception of Religious Leaders on Premarital Genetic Counseling for Sickle Cell Disease in Kano, Northern Nigeria
Authors: Galadanci Aisha A. , Ibrahim Umma A. , Farouk Zubaida L. , Abdulqadir Ibrahim , Caroll Yvonne , Ding Juan , Kang Guolin , Idris Ibrahim M. , Musa Baba M. , Mukaddas Aisha , Sani Bilya M. , Hussaini Nafiu , Umar Bashir A. , Gambo Awwal , Galadanci Hadiza , Estepp Jeremie H. , Galadanci Najibah A. , DeBaun Michaeel R.
Published: August 2024

Context:

Nigeria has the highest burden of sickle cell disease in the world. Premarital counseling (PMC) programs to reduce the burden of hemoglobinopathies have been successfully implemented in Muslim predominant countries with similar religious and cultural practices to northern Nigeria. Religious leaders have a significant role to play in the success of PMC in northern Nigeria.

Aims:

To assess the knowledge and perception of premarital genetic counseling for sickle cell disease (SCD) among religious leaders in a culturally and religiously sensitive environment.

Settings and Design:

A cross-sectional (pre and post) study was conducted during the premarital screening workshop for SCD on July 20th, 2019, at Bayero University Kano, northwest Nigeria.

Materials and Methods:

Convenient sampling method was used to identify and invite 126 Islamic clerics through the CICID (Centre for Islamic Civilization and Interfaith Dialogue) at Bayero University Kano, to a premarital screening workshop for SCD. Self-administered semi-structured pre-and posttest questionnaires were used to collect data from the participants. Aminu Kano Teaching Hospital Human Health Research and Ethics Committee approved this study.

Statistical Analysis Used:

Statistical analyses were performed with R version 4.0.2. The data were summarized using descriptive statistics and presented as mean ± standard deviation (SD), median and interquartile range (IQR), and percentages as appropriate. Wilcoxon test for score comparison of pre-and posttest was used with a significance level of 0.05.

Results:

A total of 97 religious' leaders with a mean age ± SD of 44.7 ± 12.7 completed both pre-and posttests. The male-to-female ratio was 5:1. Participants gave more accurate responses to questions during the posttest period than during the pretest; knowledge of the sign of SCD (Proportion of False Discoveries Rate (pFDR) =0.005), knowledge for the complications of SCD (pFDR = <0.001), knowledge for the best time to test for SCD (pFDR = 0.023) and perception for SCD (pFDR = <0.001).

Conclusion:

Providing health education to Islamic clerics improved their knowledge about SCD and their willingness to advocate for PMC to intending couples, and as such, we recommend that religious leaders should be involved in PMC counseling programs.
Seroprevalence of Hepatitis E among Blood Donors in Calabar
Authors: Ushie Godwin Abua , Akaba Kingsley Onorhide , Nwogoh Benedict
Published: August 2024

Context:

Hepatitis E virus is one of the reemerging pathogens of global concern with an increased risk of transmission by transfusion of blood and blood products. However, this has not been studied in our environment.

Aim:

The aim is to study the seroprevalence of HEV transmission by potential blood donors in Calabar.

Materials and Methods:

This is a cross-sectional study conducted at the UCTH Calabar. A total of 187 potential donors were enrolled. Serum IgM and IgG HEV antibodies were done on 182 donors. IgM and IgG HEV antibodies were measured using an enzyme-linked immunosorbent assay. Data generated were analyzed using the statistical package for social sciences IBM SPSS version 23.

Results:

One hundred and eighty-two participants in the study with a male-to-female ratio of 2.1:1; a mean age and standard deviation of 28.1 ± 5–7 years; 63.7%, 31.9%, and 4.4% of the study population were first-time, regular, and lapsed donors, respectively. Also, 57.1%, 41.8%, and 1.1% of the subject were voluntary, replacement, and remunerated donors; respectively. Fifty percent of the subjects were HEV seropositive, out of which 8.79% were positive for IgM-only anti-HEV antibodies, 86.81% were positive for IgG-only anti-HEV antibodies, and 7.69% were positive for both anti-HEV IgM/IgG antibodies.

Conclusion:

There is a high seroprevalence of HEV (IgM and IgG) among potential blood donors in Calabar. IgM antibodies reflect acute infections which may be subclinical as in our study population while IgG reflects past infection. The relatively high seroprevalence of IgM antibodies obtained in the index study has serious implications for transfusion safety, especially for the immunocompromised persons in the region.
Capillary hemangioma of the eye lid: A rare case in middle age adults
Authors: Pradeep Thanuja G. , Tabassum Seema , Gouri S. R. Mangala
Published: August 2024

Capillary hemangiomas are the most common eyelid lesions seen in children, however, they are rare in middle-aged individuals. They can pose a diagnostic challenge in adults when they present as acquired lesions. We present a case of acquired lid capillary hemangioma in a 48-year-old female with no other predisposing risk factors and the management. In children, spontaneous resolution is a rule, whereas in adults because of the diagnostic dilemma excision biopsy remains the mainstay of management.
Treatment of dry eyes with lifitegrast 5% before cataract surgery: A prospective trial
Authors: Yang Yelin , Gouvea Larissa , Mimouni Michael , Trinh Tanya , Santaella Gisella , Cohen Eyal , Sorkin Nir , Slomovic Allan
Published: August 2024

Objective:

The objective of the study was to evaluate the impact of dry eye treatment on intraocular lens (IOL) biometry measurements and postoperative refractive outcome.

Design:

This study involves a prospective interventional study.

Participants:

Consecutive patients with dry eye disease undergoing cataract surgery were included in the study.

Materials and Methods:

All participants underwent a comprehensive dry eye assessment including the ocular surface disease index (OSDI) questionnaire, Schirmer’s test without anesthesia, corneal fluorescein staining, and conjunctival lissamine green staining. Optical biometry was performed using swept-source optical coherence tomography (IOL Master® 700, Zeiss), and corneal aberrometry was measured using a scanning-slit aberrometer (OPD SCAN III, Nidek). Diagnosis of dry eye was made according to Dry Eye Workshop II. Patients received 6 weeks of treatment of lifitegrast 5% and preservative-free artificial tear eye drops and had repeat testing at the end of 6 weeks. The change in subjective and objective dry eye tests and biometry measurements and the difference in target and postoperative refraction before and after treatment were compared.

Results:

Forty eyes of 21 patients were included in the study. Subjectively, OSDI improved from 26.35 ± 6.24 at baseline to 20.97 ± 8.41 after treatment (P = 0.03). Objectively, corneal staining improved from 1.42 ± 1.78 at baseline to 0.39 ± 0.67 after treatment (P = 0.006). No changes were observed in Schirmer’s test without anesthesia, conjunctival staining, or corneal aberrometry (P > 0.05). Repeated biometry after dry eye treatment showed a change in IOL power difference ≥0.5 diopters in 50% (20) of eyes. Mean absolute error was within 0.25D in 87.5% (35) of eyes after treatment compared to 67.5% at baseline (P = 0.05).

Conclusion:

Dry eye treatment leads to subjective symptom improvement and changes in IOL power calculations and postoperative refractive outcomes. Assessing and treating patients for dry eyes before cataract surgery is important in maximizing refractive outcomes.
An evaluation of wet and dry needling techniques for treating myofascial pain in trapezius muscle – A meta-analysis
Authors: Ramaswamy P. , Saikiran C. H. , Swathi M. , Raj B. Mrudula , Lakshmisasi Poluri
Published: August 2024

Introduction:

Myofascial pain is a common sign of temporomandibular joint disorders and a significant cause of dysfunction in the general population. Although there are many ways to treat it, because of their ease of use and effectiveness in reducing pain, needling therapies, particularly those inside the masticatory muscles, have seen a recent surge in attention.

Aim:

The aim of the study was to evaluate the comparison between wet and dry needling therapies in myofascial pain management.

Materials and Methods:

The following study was built using the PICOS and Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocols. A comprehensive search of the literature utilizing the PubMed search engines with the keywords acupuncture, dry needling, wet needling, botulinum toxin, local anesthesia, and masticatory muscle problems was done. A total of 412 items were found after searching the databases. Finally, the analysis contained 21 publications that met the parameters.

Results:

A statistically significant (P < 0.001) impact on pain reduction was seen by this meta-analysis when comparing wet versus dry needling (mean difference = 0.80, 95% confidence interval = −0.52–2.12, n¼ 7 trials).

Discussion:

The effectiveness of wet and dry needling in treating symptoms of neck discomfort with musculoskeletal origins related to TrPs was compared in this meta-analysis. We found strong evidence that lidocaine, a local anesthetic, used in wet needling reduced pain more effectively than dry needling.

Conclusion:

Evidence from this meta-analysis suggests that in individuals with trigger points (TrPs) associated with symptoms of neck discomfort, lidocaine TrP injection works better than dry needling to reduce pain.
Optimizing pier abutment management using digital approach with nonrigid connector for superior treatment outcomes
Authors: Rathee Manu , Mittal Surbhi , Tomar Sarthak Singh , Diwan Kritika , Balavignesh S
Published: August 2024

In clinical dental practice, missing the first premolar and first molar are a common finding in the maxillary or mandibular arch. The result is a long bridge span in which the canine and the second molar act as terminal abutments and the second premolar act as a pier abutment. Teetering movements are usually observed due to the inclination of terminal abutments intruding during function, with the pier abutment serving as a pivot point. Due to these dislodging forces, the rigid fixed dental prosthesis (FDP) with pier abutment has a higher debonding rate than short-span prosthesis, resulting in marginal leakage and caries. This situation can be avoided using nonrigid connectors that act as stress breakers between the retainer and the pontic. This report describes incorporating a digitally fabricated nonrigid connector to rehabilitate a pier abutment case.
Fabrication of an interim buccal-retaining flange obturator for a patient undergoing partial maxillectomy
Authors: Algabri Radhwan , Altayyar Sadeq , Alqutaibi Ahmed Yaseen , Aboalrejal Hanan , Alhasani Abdalhaq
Published: August 2024

Prosthodontic treatment of palatal defects focuses on closing oronasal communication and improving masticatory function, speech, esthetics, and comfort. The most difficult aspect of rehabilitating patients with hemimaxillectomy is ensuring the prosthesis has enough retention and stability. During healing, a simpler design and effective retention should adequately meet the patient’s functional requirements. This case report presents the fabrication of an interim cost-effective and retentive buccal flange palatal obturator for a 65-year-old male patient who had an acquired maxillary defect resulting in mastication and deglutition difficulties. In this report, the retention of the obturator was achieved by utilizing the remaining teeth and employing a flexible thermoplastic buccal flange, with a wrought-wire U-shaped loop, on the buccal surfaces of the left canine, premolars, and molars. A complete palatal acrylic palate was designed to achieve optimal distribution of load to the surrounding tissues. To enhance patient comfort, the obturator featured a closed hollow bulb, reducing its overall bulk and making it lightweight. This interim prosthesis successfully rehabilitated the patient, resulting in improved masticatory efficiency, enhanced speech clarity, and an overall improvement in the patient’s quality of life.
Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study
Authors: Arab Hattan Mohamed , Abed Hassan , Dziedzic Arkadiusz , Nadhim Doaa , Banjar Mutaz , Metwalli Khalid , Aljabri Mohsen , Tanasiewicz Marta
Published: August 2024

Introduction:

Saliva, a versatile biological fluid, has gained recognition as an invaluable medium for point-of-care diagnostics, offering insight into the complex dynamics of periodontal tissue inflammation.

Aims:

This study aimed to assess salivary lactoferrin (LF) concentration among individuals diagnosed with periodontitis (PDS) compared to a control group.

Materials and Methods:

A randomized, observational study enrolled 441 participants residing in Southern Sweden, aged 20 and 89 years and diagnosed with PDS. Clinical examination was performed following a standardized periodontal protocol, measuring key periodontal parameters such as plaque index (PI), bleeding index (BI), periodontal pocket depth (PPD), and marginal alveolar bone level/bone loss using posterior intraoral bitewing radiographs. Stimulated saliva samples were analyzed for LF concentration using enzyme e-linked immunosorbent assay. Statistical analysis included Pearson correlation and ANOVA variance with a 95% confidence interval.

Results and Discussion:

We found no significant difference among the studied groups in mean salivary LF concentration (P > 0.05), whereas we observed a negative association between PI and salivary LF concentration (Pearson correlation = 0.110, P = 0.024), suggesting that increased plaque scores were associated with decreased LF level. In addition, smokers exhibited lower LF levels (P = 0.001). Notably, salivary LF concentration did not correlate with selected clinical parameters of PDS, including BI and PPD.

Conclusions:

These results underscore the multifaceted nature of salivary components and emphasize the need to consider various factors when evaluating the impact of PDS on saliva. Further research is imperative to validate risk factors contributing to the development of PDS and the diagnostic potential of salivary biomarkers, considering the intricate interplay between saliva and periodontal status. This study contributes valuable insight into the potential utility of saliva as a diagnostic medium.
Inserts, Screw Threads, Helical Coil 72Ni-15.5Cr-0.95(Cb+Ta)-2.5Ti-0.70Al-7.0Fe Corrosion and Heat Resistant Alloy Procurement Specification For
Authors:   E-25 General Standards for Aerospace and Propulsion Systems
Published: August 2024

This specification covers closely-wound helical coil, screw thread inserts made from an age hardenable nickel base alloy formed wire of the type identified under the Unified Numbering System as UNS N07750. The inner surface of the insert coil, after assembly into a screw thread tapped hole, provides internal threads of standard 60° Unified Form.
V2X Misbehavior Reporting
Authors:   V2X Security Technical Committee
Published: August 2024

This standard provides a specification of a general misbehavior report format suitable for reporting misbehavior observed by a system running SAE V2X applications, and specific report contents for specific instances of misbehavior. It also provides an overview of the architecture of a system-wide misbehavior management service for the V2X system and positions the misbehavior reporting services within that architecture.
THE EFFECT OF GREEN TRANSFORMATIONAL LEADERSHIP AND GREEN HUMAN RESOURCE MANAGEMENT ON ENVIRONMENTAL PERFORMANCE WITH GREEN INNOVATION AS A MEDIATING VARIABLE AT PT INDUKSARANA KEMASINDO IN JAKARTA
Authors: Nilam Edric Budiman , Pangaribuan Christian Haposan , Thaib Danial
Published: August 2024

This study aims to analyze the influence of Green Transformational Leadership (GTL) and Green Human Resource Management (GHRM) on Environmental Performance and Green Innovation, as well as the relationship between Green Innovation and Environmental Performance. This study uses a quantitative approach with the partial least squares structural equation modeling (PLS-SEM) analysis method, with Green Innovation as the mediating variable. The study uses primary data collected through questionnaires from 110 employees of PT Induksarana Kemasindo. The results show that GHRM and GTL have a significant role in improving environmental performance and green innovation (Green Innovation) at PT. However, Green Innovation does not function as a significantly mediator between GTL, GHR, and environmental performance. As a practical suggestion, companies need to improve the effectiveness of the GTL by integrating environmental sustainability principles into all aspects of human resource management and creating a work environment that supports Green Innovation.
Children's Theology: Learning Media for Sunday School Children Using Book Creator in Indonesia
Authors: Tarigan Yan Pratama , Simangunsong Bestian , Sihombing Warseto Freddy
Published: August 2024

This research wants to develop learning media for Sunday school children who seem conventional towards digital by using Book Creator. This development arose due to the need to keep up with the times, create child-friendly churches, and maintain the quality of teaching to Sunday school children. However, churches tend to be lacking in preparing the quality of Sunday school learning media. The author observes that these problems can be overcome by developing learning media that suit the needs of Sunday school children.  By paying attention to the needs of Sunday school children inseparable from the principles of theology in it, book creators are very appropriate in assisting educators to prepare quality learning. The hypothesis proposed is the basis of children's theology on Sunday school teaching materials and developing book creator-based Sunday school children's learning media  so that they can produce ready-to-use digital products. The results show that teaching materials tend to be good theologically, and teaching materials need to be developed into book creators, so that educators can improve competence and students can understand God's Word through the use of technology. In the development stage, product validation results based on material, media, and language experts showed an average of 87.6% with the category "very feasible". The methodology used is Analysis, Design, Development, Implementation, Evaluation (ADDIE) using qualitative and quantitative research in each specified stage.
The experiences of adult children caring for a parent with Korsakoff’s syndrome
Authors: Auslander Jessica , Piotrowski Nancy
Published: August 2024

Background: Korsakoff’s syndrome (KS) is a debilitating psychoneurological disorder that can occur in adults with alcohol use disorder (AUD). People with KS experience a sudden onset of symptoms including confabulation, anterograde and retrograde amnesias, apathy, issues with vision and gait, and lack of insight. Frequently an adult child of the parent with alcohol-induced KS becomes the caregiver, regardless of the status or quality of the relationship with their parent. While there is a rich literature base in the areas of adult children of parents with AUD and caregiving, there are no studies that have explored the experiences of adult children caring for a parent with alcohol-induced KS. This study aimed to explore the experiences of adult children who provide care for a parent or parental figure suffering from alcohol-induced Korsakoff syndrome (KS).
Method: This study used a generic qualitative approach with thematic analysis using both in person and web-based video interview methods and field notes to address this gap in the literature. Eight individuals participated in the study, men (n=2) and women (n=6), with participants ranging in age from 31 to 43 years (average age 37 years).
Results: Five themes emerged: addiction and the adult child, experiencing caregiver burden, experiencing a variety of emotions, professional healthcare experiences, and observations of symptoms. These themes emerged over seven anchor events in their caregiving experiences: interactions with their parent pre-diagnosis, parent’s medical emergency, hospitalization, diagnosis, housing, legal, and financial.
Conclusion: The results provide a foundation for future research in the areas of KS, caregiving, and adult children of parents with AUD. They also provide a basis to inform the development of interventions with this population and demonstrate a need for more awareness of KS among healthcare professionals.
Uniting Science and Faith: A Re-STEAM Interdisciplinary Approach in Islamic Education Learning
Authors: Adiyono Adiyono , Fitri Agus Zaenul , Al Matari Ali Said
Published: August 2024

This study explores the effective Re-STEAM (Religion, Science, Technology, Engineering, Arts, and Mathematics) interdisciplinary approach in teaching Islamic Religious Education (PAI) at SDIT Al-Khawarizmi and SDN 031 Tanah Grogot, Indonesia. The research addresses the need to revitalize PAI learning by integrating it with other disciplines, particularly science and technology. Using qualitative methods with a phenomenological approach and Multi-Site Design, the study investigates the impact of Re-STEAM on student learning outcomes. Results indicate that this approach significantly enhances students' learning motivation, critical thinking skills, and understanding of PAI materials. Integrating science and faith through Re-STEAM helps students apply Islamic values daily and prepares them for 21st-century challenges. Moreover, it demonstrates that modern science complements religious teachings, fostering a balanced development of intellectual, emotional, and spiritual intelligence. The findings suggest that the Re-STEAM approach effectively combines academic competence with strengthened faith and character, aligning with the core principles of Islamic education.
Omset Meningkat 1500% : Viral Marketing Melalui Trend Cookie Bomb Challenge Sebagai Gaya Komunikasi Pemasaran
Authors: Luqia Nurintan Cherilda , Cecep Safaatul Barkah  , Nurillah Jamil Achmawati Novel  , Iwan Sukoco
Published: August 2024

Pesatnya angka pertumbuhan pengguna sosial media membuka peluang munculnya alternatif baru dalam cara memasarkan produk dengan menggunakan jaringan internet yang biasa juga disebut sebagai digital marketing. Pengenalan merek dan kepercayaan pelanggan dapat ditingkatkan melalui penggunaan media sosial, yang juga membantu memperkuat ikatan antara bisnis dan pelanggan mereka. Semakin banyak, bisnis menggunakan strategi pemasaran viral, termasuk oleh salah satu brand yang bergerak di bidang dessert yaitu brand x yang baru saja meluncurkan produk baru bernama cookie bomb. Brand x berfokus untuk membuat konten yang membuat audiens tertarik untuk membeli produk serta berhasil memancing konsumen membagikan konten terkait pengalamannya dengan produk cookie bomb dengan mengadakan trend cookie bomb challenge. Penelitian ini bertujuan untuk mengkaji dan mendeskripsikan pendekatan viral marketing yang diterapkan oleh brand dessert di media sosial, khususnya TikTok. Ini juga menggunakan metode ini untuk menjelaskan bagaimana komunikasi pemasaran dapat memperoleh manfaat dari pemasaran viral. Studi kasus digunakan untuk melakukan penelitian kualitatif deskriptif. Informasi dikumpulkan melalui pengamatan yang cermat. Menurut temuan penelitian, ada beberapa komponen kunci untuk kampanye pemasaran viral yang sukses, yaitu kualitas konten yang diunggah, waktu unggah, kolaborasi, membangun hubungan baik dengan audiens, serta mendorong konsumen untuk membagikan pengalamannya melalui konten TikTok.
RENTALIN APPS: Development of a Motorbike Rental Application Using Design Thinking for a Digital Rental Solution
Authors: Aulia Salsabilah Sufia , Harsya  , Mentari Karenia , Monicasari Shyndy , Wijaya Hadi
Published: August 2024

The motorbike rental industry in Indonesia is characterized by significant challenges, including security risks, inefficient operations, and difficulty for customers in finding reliable rental services. This study aims to develop a comprehensive digital solution through the RENTALIN application, which addresses these challenges using a Design Thinking approach. The objective of this research was to create an application that enhances both the operational efficiency for rental owners and the user experience for customers. Data was collected from 13 motorbike rental owners, reported issues such as theft, fraud, and difficulties in tracking motorbikes. Additionally, surveyed customers indicated challenges in finding trustworthy rental services. Based on these findings, the RENTALIN application was designed with features such as GPS-based motorbike tracking, secure data verification systems, and an intuitive user interface. These solutions aim to improve security, expand market reach, and simplify the rental process. Testing of the prototype showed that the application effectively increases the efficiency and safety of the rental process, providing a more seamless experience for both rental owners and customers. RENTALIN demonstrates significant potential to become a leading platform in the Indonesian motorbike rental industry, offering targeted solutions to the sector’s critical issues.
Analisis Penggunaan Media Sosial Instagram @Potret_ Ranau Terhadap Pertumbuhan Dan Perkembangan Objek Wisata Danau Ranau
Authors: Islami Ghairun Nisya Indah , Hasmawati Fifi , Hamandia Muhammad Randicha
Published: August 2024

Penelitian ini membahas tentang penggunaan media sosial instagram @potret_ranau terhadap pertumbuhan dan perkembangan objek wisata danau ranau. Danau Ranau merupakan suatu objek wisata yang harus di kembangkan potensinya. Hal ini di karenakan danau ranau memiliki kekayaan sumber daya alam yang melimpah dan juga memiliki banyak tempat yang indah sehingga menarik banyak para wisatawan untuk berkunjung. Dalam meningkatkan pengembangan tersebut, tentu di butuhkan keterlibatan media sosial instagram untuk membantu perkembangannya agar bisa menarik banyak orang untuk berkunjung ke wisata Danau Ranau. Hal inilah yang menjadi latar belakang penelitian ini di mana peneliti ingin mengetahui bagaimana penggunaan media sosial instagram @potret_ranau terhadap pertumbauhan dan perkembangan objek wisata Danau Ranau, tujuan dari penelitian ini untuk mengetahui bagaimana penggunaan media sosial instagram @potret_ranau terhadap pertumbuhan dan perkembangan objek wisata Danau Ranau. Teknik pengumpulan data pada penelitian ini dilakukan melaui teknik dokumentasi akun instagram @potret_ranau dan wawancara. Sampel penelitian diambil menggunakan snowball sampling sehingga didapat empat informan yang merupakan followers akun instagram @potret_ranau. Hasil penelitian menunjukkan bahwa akun instagram potret_ranau menggunakan kecanggihan teknologi melalui fitur-fitur instagram yang ditawarkan guna menunjang proses pertumbuhan dan perkembangan objek wisata baik secara visual maupun verbal dengan melewati tahap: persiapan promosi, implementasi promosi, serta evaluasi dari proses promosi.