bluuebunny/crossref_metadata_2025 huggingface dataset:
Humanidades Digitais e ensino da História: O projeto 25 AprilPTLab
Authors: Marie Pierre , Réquio Pedro , Laranjeiro Dionisia
Published: January 2023

O presente artigo tem como propósito apresentar o projeto 25AprilPTLab, que visa criar uma plataforma online com conteúdos dedicados à história contemporânea portuguesa, mais particularmente a compreendida de 1958 a 1982. O artigo plasma os processos iniciais desenvolvidos no âmbito do projeto, nomeadamente os inquéritos realizados a professores com o intuito de apurar as suas dificuldades no lecionar das temáticas ligadas ao período supracitado, de que tipo de suportes necessitam e em que medida a plataforma se compromete a responder a estas problemáticas. Em simultâneo, o artigo almeja valorizar novos métodos de ensino, pesquisa e assimilação do saber histórico, articulando-os com os desafios propostos pela atualidade.
Educação bilíngue para surdos no Brasil e em Portugal: Uma revisão sistemática da literatura
Authors: Gomes Almeida Wolney , Cruz-Santos Anabela
Published: January 2023

Este artigo tem como objetivo identificar a produção científica sobre a educação bilíngue para surdos no Brasil e em Portugal, tendo em conta o reconhecimento das línguas de sinais/gestuais e as políticas públicas voltadas para um modelo bilíngue de educação de surdos. Portugal e Brasil apresentam semelhanças quanto ao reconhecimento das suas línguas gestuais/de sinais (LGP - Língua Gestual Portuguesa e Libras - Língua Brasileira de Sinais) e quanto à presença de normativas legais que preconizam o atendimento bilíngue aos surdos. Para identificação das produções, foi efetuada uma pesquisa nas seguintes bases de dados: DOAB, SciELO, Scopus, Web of Science e Wiley InterScience, tendo como palavras-chave de busca: educação bilíngue, surdos e surdez. Conclui-se que a baixa produção sobre o tema pode refletir o quão recente é o desenvolvimento das políticas de educação de surdos em ambos os países, bem como pode refletir a recente marca dos movimentos sociais de surdos nos processos de inclusão nos espaços educacionais ao longo de sua história. Após identificação dos trabalhos publicados, esta pesquisa mostrou-se relevante quanto à necessidade de ampliar a produção no campo da educação bilíngue para surdos, não apenas pela importância de discutir as políticas públicas no atendimento educacional, mas também por permitir a problematização das práticas docentes na educação inclusiva.
Prevalence of Vitamin D Deficiency among Pregnant Women in Sulaimaneyah City-Iraq
Authors: Sofihussein Hasan Qader
Published: January 2023

Hypovitaminosis D during pregnancy has a negative impact on the mother and infant’s health status. The main source of Vitamin D is sunshine and ultraviolet B for most humans and food sources are often inadequate. The present work has been carried out to demonstrate the prevalence of Vitamin D deficiency among pregnant women in the Sulaimaneyah City/Kurdistan Region of Iraq. Serum samples were collected from 261 pregnant women who attended the Teaching Maternity Hospital and met inclusion criteria and were examined for 25-hydroxyvitamin D using the Roche Elecsys Vitamin D3 assay. Different information included, including sociodemography, body mass index, and obstetric history, was collected using a specific questionnaire form. The study showed a high prevalence of hypovitaminosis D (71.3%) among pregnant women. High socioeconomic classes, blood group A-, and advanced gestational age have been significantly associated with higher Vitamin D levels. Vitamin D deficiency is prevalent in pregnant women in Sulaimani city. Because of the many risk factors of Vitamin D deficiency and a series of health consequences, the government needs to take a step to address the problem, including raising awareness among the community about the burden of the situation and how to increase obtaining optimum Vitamin D from different sources.
Nurses’ Work Concerns and Disenchantment During the COVID-19 Pandemic: Machine Learning Analysis of Web-Based Discussions
Authors: Jiang Haoqiang , Castellanos Arturo , Castillo Alfred , Gomes Paulo J , Li Juanjuan , VanderMeer Debra
Published: January 2023

Background

Web-based forums provide a space for communities of interest to exchange ideas and experiences. Nurse professionals used these forums during the COVID-19 pandemic to share their experiences and concerns.

Objective

The objective of this study was to examine the nurse-generated content to capture the evolution of nurses’ work concerns during the COVID-19 pandemic.

Methods

We analyzed 14,060 posts related to the COVID-19 pandemic from March 2020 to April 2021. The data analysis stage included unsupervised machine learning and thematic qualitative analysis. We used an unsupervised machine learning approach, latent Dirichlet allocation, to identify salient topics in the collected posts. A human-in-the-loop analysis complemented the machine learning approach, categorizing topics into themes and subthemes. We developed insights into nurses’ evolving perspectives based on temporal changes.

Results

We identified themes for biweekly periods and grouped them into 20 major themes based on the work concern inventory framework. Dominant work concerns varied throughout the study period. A detailed analysis of the patterns in how themes evolved over time enabled us to create narratives of work concerns.

Conclusions

The analysis demonstrates that professional web-based forums capture nuanced details about nurses’ work concerns and workplace stressors during the COVID-19 pandemic. Monitoring and assessment of web-based discussions could provide useful data for health care organizations to understand how their primary caregivers are affected by external pressures and internal managerial decisions and design more effective responses and planning during crises.
Adoption of Electronic Health Record Among Substance Use Disorder Treatment Programs: Nationwide Cross-Sectional Survey Study (Preprint)
Authors: Frimpong Jemima A , Liu Xun , Liu Lingrui , Zhang Ruoqiuyan
Published: January 2023

BACKGROUND

Electronic health record (EHR) systems have been shown to be associated with improvements in care processes, quality of care, and patient outcomes. EHR also has a crucial role in the delivery of substance use disorder (SUD) treatment and is considered important for addressing SUD crises, including the opioid epidemic. However, little is known about the adoption of EHR in SUD treatment programs or the organizational-level factors associated with the adoption of EHR in SUD treatment.

OBJECTIVE

We examined the adoption of EHR in SUD programs, with a focus on changes in adoption from 2014 to 2017, and identified organizational-level factors associated with EHR adoption.

METHODS

We used data from the 2014 and 2017 National Drug Abuse Treatment System Surveys. Our analysis included 1027 SUD programs (531 in 2014 and 496 in 2017). We used chi-square and Mann-Whitney U tests for categorical and continuous variables, respectively, to assess changes in EHR adoption, technology use, program, and client characteristics. We also investigated differences in characteristics and barriers to adoption by EHR adoption status (adopted EHR vs had not adopted or were planning to adopt EHR). We then conducted multivariate logistic regressions to examine internal and external factors associated with EHR adoption.

RESULTS

The adoption of EHR increased significantly from 57.6% (306/531) in 2014 to 69.2% (343/496) in 2017 (P<.001), showing that nearly one-third (153/496, 30.8%) of SUD programs had not yet adopted an EHR system by 2017. We identified a significant increase in technology use and ownership by a parent company (P=.01 and P<.001) and a decrease in the percentage of uninsured patients in 2017 (P<.001), compared to 2014. Our analysis further showed significant differences by adoption status for three major barriers to adoption: (1) start-up costs, (2) ongoing financial costs, and (3) privacy or security concerns (P<.001). Programs that used computerized scheduling (adjusted odds ratio [AOR] 3.02, 95% CI 2.23-4.09) and billing systems (AOR 2.29, 95% CI 1.62-3.25) were more likely to adopt EHR. Similarly, ownership type, such as private nonprofit (AOR 1.86, 95% CI 1.31-2.65) and public (AOR 2.14, 95% CI 1.27-3.67), or interest in participating in a patient-centered medical home (AOR 1.93, 95% CI 1.29-2.92), were associated with an increased likelihood to adopt EHR. Overall, SUD programs were more likely to adopt an EHR system in 2017 compared to 2014 (AOR 1.44, 95% CI 1.07-1.94).

CONCLUSIONS

Our findings highlighted that SUD programs may be on track to achieve widespread EHR adoption. However, there is a need for focused strategies, resources, and policies explicitly designed to systematically address barriers and tackle obstacles to expanding the adoption of EHR systems. These efforts must be holistic and address factors at multiple organizational levels.
Efficacy of an Unguided, Digital Single-Session Intervention for Internalizing Symptoms in Web-Based Workers: Randomized Controlled Trial (Preprint)
Authors: Lorenzo-Luaces Lorenzo , Howard Jacqueline
Published: January 2023

BACKGROUND

The Common Elements Toolbox (COMET) is an unguided digital single-session intervention (SSI) based on principles of cognitive behavioral therapy and positive psychology. Although unguided digital SSIs have shown promise in the treatment of youth psychopathology, the data are more mixed regarding their efficacy in adults.

OBJECTIVE

This study aimed to investigate the efficacy of COMET-SSI versus a waiting list control in depression and other transdiagnostic mental health outcomes for Prolific participants with a history of psychopathology.

METHODS

We conducted an investigator-blinded, preregistered randomized controlled trial comparing COMET-SSI (n=409) with an 8-week waiting list control (n=419). Participants were recruited from the web-based workspace Prolific and assessed for depression, anxiety, work and social functioning, psychological well-being, and emotion regulation at baseline and at 2, 4, and 8 weeks after the intervention. The main outcomes were short-term (2 weeks) and long-term (8 weeks) changes in depression and anxiety. The secondary outcomes were the 8-week changes in work and social functioning, well-being, and emotion regulation. Analyses were conducted according to the intent-to-treat principle with imputation, without imputation, and using a per-protocol sample. In addition, we conducted sensitivity analyses to identify inattentive responders.

RESULTS

The sample comprised 61.9% (513/828) of women, with a mean age of 35.75 (SD 11.93) years. Most participants (732/828, 88.3%) met the criteria for screening for depression or anxiety using at least one validated screening scale. A review of the text data suggested that adherence to the COMET-SSI was near perfect, there were very few inattentive respondents, and satisfaction with the intervention was high. However, despite being powered to detect small effects, there were negligible differences between the conditions in the various outcomes at the various time points, even when focusing on subsets of individuals with more severe symptoms.

CONCLUSIONS

Our results do not support the use of the COMET-SSI in adult Prolific participants. Future work should explore alternate ways of intervening with paid web-based participants, including matching individuals to SSIs they may be most responsive to.

CLINICALTRIAL

ClinicalTrials.gov NCT05379881, https://clinicaltrials.gov/ct2/show/NCT05379881
Traditional medicine and its impact on patient outcomes in type 2 diabetes mellitus therapy
Authors: Faridah Imaniar Noor , Perwitasari Dyah Aryani , Maer Khoirunnisa , Octapermatasari Resti , Novitasari Laras
Published: January 2023

The growing number of people with diabetes mellitus enhance the increasing number of antidiabetic medicine used and also the use of traditional medicine as a complementary medicine. The choice of treatment is depend on the patients’ perception and will have an effect on compliance and clinical outcome. This study aimed to determine the relationship between patients’ perception of consuming a combination of Traditional Medicine (TM) and Synthetic Medicine (SM) and their compliance with medication, as well as to examine its impact on the outcomes of type 2 DM treatment at three community health centers in Yogyakarta. This study is a cross-sectional study. Participants that met the inclusion criterias were 110 patients with type 2 diabetes mellitus who had been taking TM-SM combination at least one month at three community health centers in the City of Yogyakarta. The main outcome is the relationship between perception and compliance, as well as the outcome of therapy. Result showed that from 110 patients, only 40 (36.4%) had a good perception of the use of TM-SM combination, and 32 patients (29.1%) succeeded in adhering to the recommended administration of synthetic drugs. A total of 49 patients (44.5%) reported controlled blood sugar levels as the outcome of DM management. Patients' perception of drug combination was proven unrelated to patient compliance and treatment outcome (p> 0.05). For the conclusion, there is no relationship between patients’ perception of taking a combination medication with adherence and treatment outcomes.

Keywords: Compliance, Perception, Type 2 Diabetes Mellitus, Therapy Outcome
Favourable drug-lead pharmacokinetic features for designing gallic acid-standardized Syzygium polyanthum aqueous extract-based product
Authors: Hassan Fahmi Ismail  , Fadhlina Anis , Siti Nurazwa Zainol  , Archan Kumar Mamillapalli  , Vijayabalaji Venkatesan  , Rajesh Eswarappa  , Renuka Pillai  , Fadzilah Adibah Abdul Majid
Published: January 2023

In this study, Syzygium polyanthum was standardized against gallic acid (GA), and a complete pharmacokinetic test was conducted using in vitro and in vivo models against this phytochemical. High-performance liquid chromatography showed that GA is a major phytochemical in aqueous extract of S. polyanthum. It exhibited a low equilibrium solubility and physiochemical stability at pH 2.0 and 7.4, but it deteriorated rapidly at pH 9.2. It showed low permeability toward Caco-2 intestinal absorption with eight times slower absorption in oral than intravenous administration. GA was unstable in mouse, rat, and dog plasma sera with in vitro half-lives (t1/2) of 60, 53, and 56 min, respectively, but was relatively stable in human plasma serum (t1/2 = 185 min). Approximately 5.6% of GA (10 µM) bound to the human plasma proteins. GA was stable in mouse, rat, dog, and human microsomal extracts with in vitro microsomal intrinsic clearance values of 72, 68, 6, and 22 µL/min/mg, respectively. GA selectively inhibited or stimulated the activity of the tested CYP450 enzymes. The in vivo oral bioavailability of GA was 54%, with short elimination half-life and a high volume of distribution. Thus, the mention pharmacokinetic features of GA must be considered during the development of GA-based products to yield the optimum dosage and pharmacological effect.
Oral acute and subchronic (28-day) toxicity studies of snakehead fish (Channa striata)
Authors: Sasongko Heru
Published: January 2023

Food and drug control authorities in each country have issued warnings about the toxic effect potential of using commonly consumed traditional medicines. The safety assurance, standardization, and market regulation of herbal medicines being sold need to be determined. This study's goal is to investigate the acute and subchronic toxicity of cold-processed snakehead fish (Channa striata) flesh. In-vivo rats models were given dosages of 350, 1400, and 5600 mg/kg processed snakehead fish (SF) and were monitored for toxic symptoms and mortality for 14 days. Meanwhile, regarding subchronic toxicity, doses of 350, 700, and 1400 mg/kg SF were administered orally for 28 days. Afterward, the animal subjects were sacrificed for histopathological, hematological, and biochemical examinations. There were no evidence of toxicity or mortality in rats during the acute examination, which lasted 14 days. The subchronic toxicity results showed no significant changes in most of the hematological, biochemical, and histological profiles of the organs. Some changes observed in blood biochemistry and relative organ weight were assumed as a temporary effect and not a sign of toxicity. The overall results showed that the SF was non-toxic up to 1400 mg/kg, which can be considered a safe dose for the application of health supplement raw materials.
Tyrosinase Inhibitory and Antioxidant Activity of Paederia foetida L.
Authors: Fawwaz Muammar , Rifai Yusnita , Djabir Yulia Yusriani , Mukhriani  , Alam Gemini
Published: January 2023

Paederia foetida L. is a tropical Asian plant containing bioactive compounds and often used as functional foods. The aim of this study was to determine the antioxidant capacity and inhibitory activity of P. foetida leaves extract on tyrosinase activity. In addition, the total phenolic content (TPC) and total flavonoid content (TFC) were determined. TPC and TFC was evaluated by the Folin-Ciocalteu and the aluminum chloride (AlCl3) colorimetric method, respectively. The antioxidant capacity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC) method. The antioxidant capacity was expressed as trolox equivalent antioxidant capacity (TEAC) dan ascorbic acid equivalent capacity (AAEC). The tyrosinase inhibitory activity was conducted by enzyme-linked immunosorbent assay (ELISA) using L-tyrosine as a substrate and measured at 490 nm by ELISA reader. TPC in the crude extract, fraction A, and fraction B was 173.18 ± 3.99, 553.95 ± 5.70 and 405.37 ± 33.90, respectively. TFC in the crude extract, fraction A, and fraction B was 12.79 ± 0,25, 143.16 ± 9.27, 143.50 ± 6.90, respectively. The best antioxidant capacity of the extract was shown in the DPPH method (15.71 ± 1.6 mg TEAC/g and 100.77 ± 8.5 mg AAEC/g). Meanwhile, fraction B showed the best antioxidant capacity by the FRAP (11.48 ± 1.5 TEAC/g and 8.39 ± 1.2 mg AAEC/g ) and CUPRAC (116.34 ± 1.9 mg TEAC/g and  66.11 ± 1.3 mg AAEC/g) methods. Tyrosinase inhibitory activity exhibited that the IC50 of fraction A and B was 13.67 μg/mL and 13.37 μg/mL, respectively.
Apium graveolens and Eucalyptus globulus Decrease Stress and Protect Folliculogenesis Marker on Woman Reproductive Health during COVID-19 Pandemic
Authors: Novika Revi Gama Hatta , Wahidah Nurul Jannatul , Rahmawati Nanda Yuli , Ansori Arif Nur Muhammad
Published: January 2023

Stress during the COVID-19 pandemic affects the physiological and immunological response to women's reproductive health. Eucalyptus globulus and Apium graveolens are immunomodulators related to women's reproductive health. This study aimed to investigate E. globulus and A. graveolens towards the expression of Heat Shock Protein-70 (HSP70) and tumor necrosis factor-alpha (TNF-α) as stress markers, luteinizing hormone (LH), and Growth Differentiation Factor 9 (GDF-9) as folliculogenesis markers. This study was an experimental randomized controlled trial using a pre-posttest control group design. Sixty women of reproductive health age who had stress based on the DASS-21 questionnaire were divided into two groups at area of Nusukan Health Center, Indonesia. The intervention group was given 300 mg A. graveolens capsules orally and E. globulus essential oil for 14 days. The control group was given a placebo. Blood samples and stress levels were evaluated before and after the intervention to determine the effect of the intervention. There was no difference in stress levels in the control and treatment groups at pre-test. The intervention group decreased HSP70, TNF-α, and stress levels (p<0.001). A significantly decreased TNF-α increased LH level (p<0.001). Moreover, LH and GDF-9 levels increased in the intervention group compared to the control group (p<0.001). In summary, A. graveolens supplementation and E. globulus essential oil decreased stress and protected folliculogenesis markers on women's reproductive health due to stressful conditions during pandemic COVID-19.
Geowisata dan Potensi Penguatan Komunitas pada Wisata Pasca-Tambang Open Pit Nam Salu di Belitung Timur
Authors: Aryanto Peranciscus , Hendarmawan Hendarmawan , Hadian Mohamad Sapari Dwi , Novianti Evi , Faramitha Syintia
Published: January 2023

Pariwisata merupakan salah satu sektor yang memberikan nilai dan manfaat bagi peningkatan perekonomian masyarakat dan mempengaruhi sektor lainnya. Oleh karena itu, perlu dilakukan identifikasi potensi wisata dan sumber daya yang ada untuk memudahkan penyusunan konsep perencanaan dan pengembangan pariwisata yang juga harus mempertimbangkan dampak positif dan dampak negatif yang dihasilkan. Dampak positif akan berpengaruh pada perekonomian masyarakat sedangkan dampak negatifnya adalah kerusakan alam dan perubahan budaya pada masyarakat. Pengembangan pariwisata perlu melibatkan masyarakat dalam mengelola keunikan dan kondisi daerah yang ada. Open Pit Nam Salu merupakan salah satu objek wisata eks tambang yang memiliki potensi menarik. Sebagai tambang timah terbesar di Asia Tenggara, kawasan objek wisata ini memiliki terowongan bawah tanah yang menjadi salah satu kegiatan yang menarik wisatawan yang berkunjung. Setiap pengunjung wajib mengikuti protokol keselamatan dan kesehatan yang ada. Obyek wisata Open Pit Nam Salu saat ini dikelola oleh Bapopnas (Badan Pengelola Open Pit Nam Salu). Dalam pengembangan kawasan ini ada beberapa kendala yang dihadapi diantaranya sarana dan prasarana serta keterbatasan sumber daya manusia pariwisata dalam mengelola kawasan ini. Penulis melakukan penelitian pengembangan kawasan ini menggunakan metode kualitatif deskriptif dengan pengumpulan data melalui wawancara dan observasi lapangan. Hasil penelitian menunjukkan bahwa pemberdayaan masyarakat yang dilakukan melalui Bapopnas, pengembangan pariwisata kawasan ini sudah menunjukkan perubahan yang terlihat dengan adanya pembangunan sarana dan prasarana, promosi dan pemasaran melalui media sosial dan keikutsertaan dalam kegiatan pelatihan.
Investigating the Link Between Human Health and Technical Efficiency: A Case Study of Oil Palm Processors in Nigeria
Authors: Ugbekile Peace Chukwuyem , Oyekale Tolulope Olayemi
Published: January 2023

The relationship between health status and technical efficiency cannot be over-emphasized although most researchers in the past have failed to recognize the possibility of an existing relationship between these variables. This study examined the cost implication of illnesses and their effect on the technical efficiency of oil palm processors in Edo State. A multistage sampling procedure was used to select 210 oil palm fruit processors in the study area. Data were analyzed using frequency counts, percentages, Cost-of-Illness estimation and Stochastic Production Frontier Analysis (SPF). Results revealed that the major illnesses experienced by the processors were malaria (100.0%), cough and catarrh (100.0%), back pain (98.8%), skin rash (78.9%) and nausea (76.6%). The estimated cost of illness was N165,338.80 with total time cost contributing 97.02% of this value for the period under consideration. SPF revealed that the mean technical efficiency of the oil palm processors was 0.75. Furthermore, palm fruits (β = 0.662, p<0.01), the volume of water used (β = 0.180, p<0.05), labor (β = 0.415, p<0.01) and processing experience (β = -0.110, p<0.05) increased the production of palm oil, while days of incapacitation (β = 0.445, p<0.01) increased technical inefficiency. The study concluded that illnesses had a negative influence on the technical efficiency of oil palm processors. The study recommended that stakeholders should create awareness of a healthy lifestyle and practical ways to maintain good health while ensuring continuous production.
THE CONTENT ANALYSIS OF BAHASA INGGRIS TEXTBOOK USED IN THE FIRST CLASS OF SENIOR HIGHT SCHOOL 1 NAN SABARIS
Authors:   STKIP YDB Lubuk Alung, Johari Indra , Syaveny Niza ,   STKIP YDB Lubuk Alung
Published: January 2023

This research was based on varieties textbook circulating in learning. The method used in this research is descriptive research method, by analyzing the book "English" Semester 1 published by the Ministry of Education and Culture, English Language Book Revised 2017. The instrument used by the researcher was the Assessment rubric from the National Education Standards Agency Badan Standar Nasional Pendidikan (BSNP) and Documentation. The data were analyzed by using the conformity tabulation of the BSNP rubric and the range category in percentage form. The results of this study indicate that the total percentage obtained is 93.75% and is included in the Good category. This total percentage is obtained from the score on Material Completeness in 5 chapters getting a score of 4 or reaching 95% of the completeness of the material and 1 chapter getting a score of 1 or less than 95% of the completeness of the material. The in-depth score obtained in 5 chapters gets a score of 4 or 95% of the specified in-depth and 1 chapter gets a score of 1 or less than the specified 95% in-depth. The percentage assessment on the Social Function from Chapters 1-6 gets a score of 6 or reaches 95% of the social function provisions of the BSNP. The percentage value of Generic Structure here is 5 chapters getting a score of 4 or meeting 95% of the Generic Structure standards available in the BSNP rubric and 1 chapter getting a score of 1 or the achievement of Generic Structure is less than 95%, the percentage results from Linguistic Features in all the subjects studied are from the chapter 1-6 get a score of 4 or the percentage of achievement from Linguistic Features reaches 95%. The percentage achievement for Supporting Materials has 3 assessment points, namely Relevance, Development of Life Skills and Development of Diversity Insight. Here in chapters 1-6 each gets a score of 4 or reaches 95% of each category. So based on the results that have been examined in this study, the percentage category of achievement of this book is included in the Good category.
Principles of Architectural Form Harmony in The Process of Restoration and Conservation of Architectural Monuments
Authors: Muratkulovich Abduraimov Sherzod
Published: January 2023

Abstract: In the article, the history of the construction of monuments in Uzbekistan, their architectural formation, their initial function, the architectural and functional changes that took place before they came to us, the historical value of the monument, from the material, structural, artistic and architectural aspects. principles such as the level of preservation, determining the extent to which monuments need conservation and restoration, as well as the architects of the past, before constructing buildings and structures that have been preserved in the form of monuments to us, drew their drawings, that is, their design, style, views of devices, decorations, patterns he worked on the layouts, fragments, drafts and projects, and in some cases, the model or layout of the future building, the proportions of architectural forms, paigor in the drawing, all proportions used in architecture, the law of proportionality and harmony in architecture, architectural decorations the principles of how it is designed in accordance with the building forms are described.
Text Interpreter and Converter
Authors: Vasudev Arpitha , R Karthik M , Pranav K. , Monsih  , Davya Sai
Published: January 2023

Abstract: With the exponential growth in data, it is essential to analyse it. The data is a valuable source of information and knowledge that should be effectively interpreted to be helpful. The data should be interpreted in different forms based on the user requirements to get precise information and knowledge. Nowadays smartphones are the most commonly used electronic device. A smartphone is not only a communication device, it is also a powerful computing device. So it is possible to apply translation, text extraction, summary, and much more techniques, which require much computational work. This paper presents an application to analyse the text from documents on smartphones. However, it is challenging to interpret the documents on smartphones. The proposed application converts the documents or images to searchable and editable digital text, and further, it can be used to analyse them into different forms. The objective of this application is four-fold 1) To recognize text from documents or images by using optical Character Recognition 2) Summarization of the text 3) Translate the extracted text to different languages 4) Generation of speech from the text by using a text-to-speech algorithm.
Neoliberalismo tecnoprogresista y sus alternativas: el caso de Mercado Libre y la organización Transistemas
Authors: Palermo Hernan , Ventrici Patricia , Santarcieri Rocío
Published: January 2023

El presente artículo indaga sobre los sentidos y valores que instala la agenda empresarial de Mercado Libre, la líder en e-commerce de Latinoamérica. Partiendo de un relevamiento sistemático de sus apariciones en medios de comunicación y redes sociales, abordamos las significaciones sobre la inclusión y los imaginarios de futuro que promueve como empresa de uso intensivo de tecnología. La agenda tecno-inclusiva que propone el neoliberalismo tecnoprogresista se nutre de reivindicaciones de los nuevos movimientos sociales para revitalizar la idea de sujeto emprendedor hiperindividualizado y posicionar a la innovación tecnológica como centro del bienestar social. Asimismo, tomamos la experiencia activista de Transistemas, una organización social integrada por personas del colectivo LGTBIQ+ que genera propuestas para la inserción laboral formal en la industria informática. Tomando estos dos casos analizamos la tensión entre la agenda hegemónica neoliberal tecnoprogresista y las resignificaciones que se producen sobre ella a partir del activismo político de base.
Pengembangan Lembar Kerja Peserta Didik Interaktif Menggunakan Liveworksheet pada Materi Teks Eksplanasi
Authors: Aryani Dessy , W Imam Suwardi , Priyanto Priyanto
Published: January 2023

Penelitian ini bertujuan untuk menjabarkan proses pengembangan LKPD interaktif menggunakan liveworksheet, kepraktisan LKPD interaktif, dan keefektifannya. Jenis penelitian berupa pengembangan atau Research and Development (R&D) dengan model 4-D yaitu pendefinisian (define), pengembangan (design), perancangan (develop), dan penyebaran (disseminate). Subjek dalam penelitian ini adalah siswa kelas VIII SMP Negeri 17 Kota Jambi. Dalam proses pengembangan diperoleh hasil akhir validasi media dan validasi materi  dengan kategori valid. Pengembangan LKPD dapat dinyatakan efektif berdasarkan selisih nilai N-gain tes awal dan tes akhir pada kemampuan kognitif dan psikomotorik. Pada aspek kognitif diperoleh nilai N-gain sebesar 0,62 dan aspek psikomotorik diperoleh nilai N-gain sebesar 0,69. Keduanya termasuk dalam kategori sedang. Berdasarkan hal tersebut, LKPD interaktif liveworksheet yang dikembangkan dapat digunakan menjadi bahan ajar pada materi teks eksplanasi pada jenjang SMP.
Penerapan Media Digital Storytelling untuk Meningkatkan Kualitas Pembelajaran Kemampuan Menulis Berita
Authors: Wulan Andi Naga , Budiyono Herman , Wibowo Imam Suwardi
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan kualitas pembelajaran kemampuan menulis berita siswa kelas VIII di salah satu sekolah menengah pertama yang ada di Muaro Jambi, Provinsi Jambi. Jenis penelitian ini yaitu Penelitian Tindakan Kelas (PTK) dengan menerapkan media digital storytelling. Metode pengumpulan data dengan cara observasi, wawancara, dan tes. Hasil penelitian menunjukkan bahwa penerapan media digital storytelling dapat meningkatkan kualitas proses dan hasil pembelajaran. Pada prasiklus, kualitas proses pembelajaran kurang baik (2,45). Siklus 1, kualitas proses pembelajaran masih kurang baik (2,9). Siklus 2, kualitas proses pembelajarannya baik (4,1). Sementara dari hasil unjuk kerja siswa saat menulis berita menunjukkan bahwa adanya peningkatan kemampuan menulis berita. Hasil prasiklus menunjukkan nilai rata-rata siswa yaitu 28,2. Siklus 1 mengalami peningkatan menjadi 56,4. Siklus 2 berhasil mencapai indikator pembelajaran dengan nilai rata-rata yaitu 87,1. Berdasarkan hasil penelitian ini, pendidik dapat menggunakan media digital storytelling untuk pembelajaran menulis berita.
Pengaruh Model Pembelajaran Studysaster Terhadap Kemampuan Menulis Teks Berita Berbantuan Media Podcast
Authors: Hassyah Yudistin  , Lutfi Syauki Faznur  , Nurhamidah Didah
Published: January 2023

Penulisan artikel ini dilatarbelakangi oleh kurangnya penguasaan peserta didik pada mata pelajaran bahasa Indonesia khususnya materi teks berita. Selain itu, bila dibandingkan dengan aspek pengetahuan, kecakapan peserta didik terkait keterampilan menulis masih tergolong rendah.. Tujuan penelitian ini yakni untuk mengetahui adanya pengaruh penggunaan model pembelajaran Studysaster dan media Podcast terhadap kemampuan peserta didik khususnya menulis teks berita. Subjek penelitian ini yakni peserta didik kelas VIII-1 dan VIII-3 MTs Al-Ihsan Pamulang. Kedua kelas tersebut digolongkan ke kelompok eksperimen dan kontrol.Adapun metode yang difokuskan yakni True Experimental Design dengan teknik Posttest-Only Control Group Design. Hasil yang didapat berdasarkan penelitian ini yakni terdapat pengaruh signifikan dari pengaplikasian model Studysaster dan media Podcast dalam pembelajaran teks berita. Hal tersebut ditunjang dengan pencapaian nilai yang diperoleh peserta didik kelas eksperimen (82,12) lebih unggul dibanding kelas kontrol (64,56). Berdasarkan hasil uji hipotesis, diperoleh thitung > ttabel yakni 11.131 (> 1.66757), dan nilai sig. 0,000 (< 0,05) maka disimpulkan bahwa Ha diterima. Berdasarkan hal tersebut, maka terdapat pengaruh model pembelajaran Studysaster terhadap kemampuan menulis teks berita berbantuan media Podcast.
Ikon, Indeks, dan Simbol pada Cerpen Sesat Pikir Para Binatang Karya Triyanto Triwikromo
Authors: Fadhilla Indah , Hidayatika Uliana , Hira Hanna Hanifa , Farihah Hanan , Nabilah Ainatun
Published: January 2023

Abstrak

Pembahasan dalam penelitian ini adalah mengenai ikon, indeks, dan simbol dalam cerpen “Sesat Pikir Para Binatang” karya Triyanto Triwikromo. Tujuan penelitian ini adalah untuk mengetahui berbagai tanda dalam bentuk ikon, indeks, dan simbol di cerpen “Sesat Pikir Para Binatang” karya Triyanto Triwikromo dan mengungkapkan makna atau amanat yang dapat diambil dari bentuk simbol. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Tahapan yang peneliti lakukan adalah proses pengumpulan data, proses analisis data, dan penyajian hasil analisis data. Penelitian ini menemukan bahwa terdapat ikon, indeks, dan simbol dalam cerpen “Sesat Pikir Para Binatang“ karya Triyanto Triwikromo untuk menggambarkan kemiripan antara naluri manusia dan insting binatang seperti kebuasan, kelabilan, dan keangkuhan. Penggambaran kemiripan ini bertujuan untuk mengkritik tingkah laku atau perilaku buruk manusia.

Kata kunci: Ikon; Indeks; Simbol; Insting binatang; Naluri manusia

 

Abstract

The discussion in this study is about icons, indexes, and symbols in the short story "Sesat Pikir Para Binatang" by Triyanto Triwikromo. The purpose of this study was to find out the various signs in the form of icons, indexes, and symbols in the short story "Sesat Pikir Para Binatang" by Triyanto Triwikromo and reveal the meaning or mandate that can be taken from the form of symbols. This study uses a qualitative method with a descriptive approach. The stages that the researchers did were the data collection process, the data analysis process, and the presentation of the data analysis results. This study found that there are icons, indexes, and symbols in the short story "Sesat Pikir Para Binatang" by Triyanto Triwikromo to describe the similarities between human instincts and animal instincts such as savagery, instability, and arrogance. The depiction of this resemblance aims to criticize human behavior or bad behavior.

Keywords: Icons; Index; Symbol; Animal instinct; Human instinct
Ekranisasi Novel Senior Karya Eko Ivano Winata ke Film Senior Karya Indra Gunawan
Authors: Esadiani Akmalia , Fitri Alya , Rahmani Mahabbati Izzati , Hidayatullah Syarif
Published: January 2023

Abstrak

Ekranisasi dapat diartikan sebagai bentuk penyampaian pesan dari sebuah karya sastra menjadi bentuk yang lain. Tujuan penelitian ini yaitu untuk mengungkapkan proses ekranisasi yang terjadi dari novel Senior karya Eko Ivano Winata ke dalam film Senior karya Indra Gunawan. Metode yang digunakan penulis dalam mengkaji proses ekranisasi yaitu dengan metode deskriptif kualitatif. Teknik yang digunakan untuk memaparkan data yaitu dengan teknik membaca, mencatat, yang meliputi penambahan, pengurangan, dan perubahan bervariasi yang terjadi pada novel dan film Senior. Hasil penelitian dari proses ekranisasi yang telah dikaji memaparkan mengenai penambahan, pengurangan, dan perubahan bervariasi yang berkaitan dengan alur, latar, dan tokoh dari novel Senior karya Eko Ivano ke film Senior karya Indra Gunawan. Terdapat 6 penambahan alur, 6 pengurangan alur, dan 2 perubahan bervariasi alur. Lalu terdapat 2 penambahan latar, tidak terdapat penciutan latar dari novel ke film, dan 1 perubahan bervariasi latar. Lalu terdapat 1 penambahan tokoh, 3 penciutan tokoh, dan 1 perubahan bervariasi pada tokoh.

Kata Kunci : Ekranisasi, Novel, Film

Abstract

Ecranization can be interpreted as a form of conveying messages from a literary work into another form. The purpose of this study is to reveal the ecranization process that occurs from the novel Senior by Eko Ivano Winata into the film Senior by Indra Gunawan. The method used by the author in studying the ecranization process is a qualitative descriptive method. The technique used to present the data is by reading, taking notes, which include adding, subtracting, and various changes that occur in the novels and films of Senior. The research results from the ecranization process that has been studied describe the addition, subtraction, and various changes related to the plot, setting, and characters from the novel Senior by Eko Ivano to the film Senior by Indra Gunawan. There are 6 groove additions, 6 groove reductions, and 2 changes to varying grooves. Then there are 2 background additions, no background shrinkage from novel to film, and 1 change in various settings. Then there is 1 character addition, 3 character shrinkages, and 1 variable change in character.

Keywords: Ecranization, Novel, Film
Rare Case of Metaplastic Breast Carcinoma with Squamous Differentiation in Young Female: A Case Report
Authors: Agustina Rohana
Published: January 2023

Background. Metaplastic breast carcinoma is a very rare breast cancer, only about 0.2"‘1% of all invasive breast carcinomas. The prognosis of these cancer is poor and aggressive, reported to have lower response rates to conventional adjuvant chemotherapy and a worse clinical outcome after chemotherapy than other forms triple"‘negative breast carcinomas. Histopathologically, metaplastic breast carcinoma has distinct patterns with different outcomes. Among the types of metaplastic carcinoma, squamous cell, high grade spindle cell and high grade adenosquamous carcinoma are associated with the worst prognosis. We report one case of metaplastic breast carcinoma with squamous differentiation in young patient.

Methods. We examined the breast tumor tissue of a female patient, evaluated the macroscopic and microscopic features and asked the patient about the clinical course of the disease. Inform consent was obtained from the patient for publication of this case report and accompanying images.

Results. We reported a young female patient with final diagnosis of pathology Mixed Infiltrating Duct Carcinoma of No Special Type Grade 3 and Metaplastic Breast Carcinoma with Squamous Differentiation (30%) that has invaded fat tissue with Ductal Carcinoma Insitu of High Nuclear Grade 3 with basis of the operation is still positive for the tumor mass. Patients lost follow"‘up and did not continue therapy.

Conclusion. Morphology of metaplastic breast carcinoma are important factors influencing patient outcome. Early diagnosis and wide local excision of the squamous"‘type metaplastic breast carcinoma mass can make a better prognosis.
Karakteristik Mutasi EGFR pada Pasien Kanker Paru Jenis Adenokarsinoma yang Diterapi dengan Tyrosien Kinase Inhibitor (TKI) di Rumah Sakit Paru Dr. H.A Rotinsulu Bandung
Authors: Puspita Desi , Dwi Astuti Vitri , Rina  , Sampurno Edi
Published: January 2023

This descriptive study describes the proportion of Epidermal Growth Factor Receptor (EGFR) mutations in lung cancer Adenocarcinoma patients at Rumah Sakit Paru (RS Paru) Dr. H. A Rotinsulu Bandung in the range of 2018 to 2020. 

EGFR mutations were examined using RGQ thera screen technology Real"‘Time Polymerase Chain Reaction from FFPE or cytology smear.

There are 44 data point mutations after examining the EGFR mutation. 59% cases were 40"‘60 years old group dan 52 % were female.

It was found that in this group 86% patient with single mutation and 16% had doube mutations. EGFR mutations occurred in Exon 21 L858R in 13 cases (30 %), Exon 21 L861Q in 1 case (2%), Exon 19del in 24 cases (55%), double mutation Exon 19 and Exon 20 T790M type in 2 cases (4%), double mutation Exon 19del and Exon 21 in 4 cases (9%).
THE A Comparative Review on Allium Sativum and Phyllanthus Emblica
Authors: Raj Mukut , Vyas Girish Kumar , Sharma Shailesh , Bishnoi Hansraj
Published: January 2023

Allium sativum and Phyllanthus emblica have the ability to treat a variety of disorders through diverse formulations. The goal of this comparative analysis is to assess the extractive properties of both plants in various solvents based on their polarity. I've noticed that ethanol has a high potential for extracting the API from the crude medicine, which may be emblica or sativum. As a result, additional assessment and research will be conducted with the consideration of plant potential and extractive production. This review article provides information about these plants, their common names, and their diverse activities in relation to various ailments.
Review: Phytochemical of Some Plants with Anticoagulant
Authors: Sitiawani Meisy , Azizah Zikra , Asra Ridho , Chandra Boy
Published: January 2023

Background: Anticoagulants are drugs used to treat hypertension and cardiovascular disease.This review article aims to discuss several types of natural plants with anticoagulant activity.

Materials and Methods: The method used is the study of relevant literature(national and international journals) which is accessed through online sites such as Google Scholar, Research Gate, Science Direct, Springer Link, and NCBI, published in the last 10 years (2011-2021) with the keyword “herbal plant” or “medicinal plant” and “anticoagulant” and “cardiovascular”.

Results: Based on in vitro and in vivo tests, some plants such as Allium sativum L., Averrhoa bilimbi, Persea americana Mill., Tridax procumbens L., Carica papaya L., Rhizophora sp, Syzygiumcumini L., Piper batle L., Erigeron canadensis L., Ainsliaea fragrans, Averrhoa bilimbi, Carica papaya L., are types of plants with anticoagulant activity.

Conclusion: Herb can be used as alternative sources of new anticoagulant agents cause of their biological activity. The use of medicinal plants with therapeutic effects and minimal side effects can be the best choice for the prevention and treatment of various diseases including cardiovascular disorders.
A Review on Microspheres: Preparation, Characterization and Applications
Authors: Galande Prasad , Yadav Vishal , Borkar Smita
Published: January 2023

Small sphere-shaped particles are known as microspheres and their particle size range is 1micrometer to 1000 micrometer. They are free-moving, spherical particles that can be manufactured from proteins or artificial polymers. There are several methods for delivering a medicinal chemical to the target region with a regulated, prolonged release. which naturally decomposes.Microcapsules and micromatricesare two of the different types of microspheres. There are numerous varieties of microspheres that are described. Microspheres are one of the most popular varieties and provide a number of benefits.Theseprepared microspheres can be compressed or filled with a firm gelatin. There are several methods for creating microspheres, including single-emulsion, double-emulsion, solvent evaporation, phase separation coacervation, and spray drying. Microspheres are assessed using a variety of assessment methods, and they are examined in relation to a number of applications, including the delivery of vaccines, chemotherapy, ophthalmic drugs, gene therapies, and oral, nasal, and buccal drug delivery of pharmaceuticals.
A Comparative Study of Biologic Regulation in US, Canada, Australia, Europe and Singapore
Authors: Patel Yesha , Patel Amit A. , Patel Ravish J.
Published: January 2023

Extensive research in chemistry, manufacturing, controls, preclinical science, and clinical trials is required when developing a novel biological medication. Drug reviewers in regulatory bodies throughout the world and all regulatory bodies are entrusted with determining whether research evidence establishes new drug product safety, effectiveness, and quality control in order to protect public health. Among the world every province has its own regulatory organization in charge of enforcing laws and regulations and developing guidelines for drug marketing. There are some particular requirements sets by regulatory authority that must be satisfied when submitting in the particular nation. The world is split into various approval procedures, it is pivotal for manufacturers to carefully assess market interest, expenditures, target zones, and regulatory standards before establishing biologics. Despite the existence and widespread adoption of an ICH-CTD standard format, some limitations are included. This article discusses the comparison considerations used for biological product approval in the United States, Canada, Europe, Australia, and Singapore.