bluuebunny/crossref_metadata_2025 huggingface dataset:
The Implementation of Character Education in Indonesian Language Learning for Class 3C Students at SDS IT Nurul Yaqin, East Jakarta
Authors: Sumadyo Bambang , Susanti Dewi Indah , Prameswari Jatut Yoga
Published: August 2024

This research aims to describe and explain that through the implementation of character education in Indonesian language learning for class 3C students at SDS IT Nurul Yaqin, East Jakarta, it can be a forum for preventing the occurrence of moral and social problems that occur in schools. The emergence of these social and moral problems giving rise to demoralization and immoral acts that occur as a result of there being no platform that supports students to channel their creativity and curiosity. This is qualitative research with descriptive methods. Interviews, observation and documentation are used as data collection techniques in this research. Research data analysis techniques This is data reduction, data presentation, and drawing conclusions. The population and sample in this study were class 3C students at SDS IT Nurul Yaqin, East Jakarta. The results of the study showed that the character values obtained from the students were religious, tolerance, discipline, work hard, independent, creative, curious, likes to read, friendly/communicative, and responsible. The implementation of character education in Indonesian language learning is seen from 3 aspects: 1). learning planning, 2). implementation of learning, 3). Learning evaluation." The implication that can be given in the research is that students will be creative in carrying out various tasks and developing their four Indonesian language skills. It is hoped that the school and parents can work together in providing space for students to develop themselves through character education by providing space. their creativity in learning.
Unveiling Student Experiences with Project Based Learning (PjBL): Insights from Jambi University
Authors: Tersta Friscilla Wulan , Berliana Winny , Safitri Nyimas Triyana , Anastasia Indri
Published: August 2024

The purpose of this research is to find out the perceptions of students towards Project Based Learning (PjBL)-based learning at one of study program in Jambi University which has been implemented for approximately 2 years. This research used a type of qualitative research with a case study. Data collection techniques used by researchers consist of observation, interview and documentation techniques. There are six themes emerged in this research: Learning experiences, Long-term Memory Retention, Student Creativity Enhancement, Time Intensiveness, Leadership Development and Responsibility, Flexibility in Learning. It is suggested that further research and exploration be conducted to address the challenges and preferences identified by students and lecturers regarding PjBL.
Narrative Review of Medication-Induced Abortion and Care through Telemedicine
Authors: Wen Ao , Zhou Kunyan
Published: August 2024

Objective: This review aims to examine the role of telemedicine in facilitating access to medication-induced abortion services, in the context of legal restrictions, geographical barriers, and the impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare delivery. Mechanism: This study conducted a narrative literature review focusing on the application of telemedicine in abortion care. It included analyzing various study types and evidence from peer-reviewed articles to evaluate the effectiveness, safety, and patient reception of telemedicine in providing medication-induced abortion. Findings in Brief: Medication-induced abortion via telemedicine is safe, effective, and well received by patients, offering a viable alternative to traditional in-person services. Telemedicine enables remote eligibility assessment, medication prescription, and follow-up care, significantly benefiting isolated or underserved populations. Conclusions: Telemedicine has emerged as a critical innovation in abortion care, enhancing access, safety, and equity in abortion services. It addresses significant barriers such as travel expenses and missed work, providing a patient-centered approach to abortion care. Future directions should focus on optimizing telemedicine protocols and expanding access to underserved populations, ensuring comprehensive abortion care through telemedicine.
Kisspeptin-10: A Predictor for Fetal Growth Restriction among Preeclamptic Women that Discriminated Early Onset Cases
Authors: Abdalqader Manal Madany , Hussein Shatha Sami , Jadi Huda Fadhil , Nori Wassan
Published: August 2024

Background: Preeclampsia (PE) is a major cause of maternal and neonatal morbidity. Fetal growth restriction (FGR) shares many pathophysiological roles with PE. Kisspeptin-10 is a peptide secreted by placental syncytium. It was linked to many adverse pregnancy events. The current study aimed to examine Kisspeptin’s-10 role in predicting FGR in PE pregnancies and to verify whether it can predict its onset as early or late FGR. Methods: An observational case-control study enrolled 120 eligible cases at matched gestational age (28–40 weeks) and body mass index (BMI); they were divided into 2-groups: (60) healthy controls and (60) PE cases. PE cases were subdivided into early onset FGR (28/60), who had a gestational age less than 34 weeks, and late-onset FGR (32/60) with a gestational age equal to 34 weeks. A collection was made of the following data: first: pregnant primary criteria [age, BMI, systolic and diastolic blood pressure (BP), and urine for albumin], second: serum Kisspetein-10 was evaluated via enzyme-linked immunosorbent assay (ELISA), and third: ultrasonic criteria [estimated fetal weight, resistance, and pulsatility index (RI, PI)] were recorded for all. Results: Serum Kisspeptin-10 was significantly higher among the controls (309.56 ± 67.72) followed by late-onset FGR and early onset FGR (235.46 ± 68.97) vs. (212.09 ± 58.44) ng/dL; p = 0.0001 respectively. It was negatively linked to systolic, diastolic BP, and urine for albumin; Pearson correlation coefficient (r) was (–0.29, –0.48, –0.28) respectively; p < 0.0001, 0.0018, 0.028 respectively. Kisspeptin-10 was positively linked to estimated fetal weight (r = 0.27; p = 0.034); it had an odds ratio (OR) of 3.04; 95% confidence interval of (1.37–4.765); p = 0.0001 in discriminating healthy pregnancies from FGR cases. Conclusions: The significant correlation of Kisspeptin-10 with PE parameters and estimated fetal weight with high sensitivity, specificity and reliable area under the curve in predicting early onset FGR cases make it recommended for practice in predicting FGR onset.
Implementation of a Macroporous Polyhydroxyethylmethacrylate Cryogel-Based Mini-Bioreactor System to Improve Monoclonal Antibody Production
Authors: Indiramma Jyothilekshmi , Tetala Kishore K. R. , Jayaprakash N.S.
Published: August 2024

Background: Monoclonal antibodies (mAbs) are pioneers in the diagnosis and treatment of many diseases, such as cancer, asthma, poisoning, viral infections, etc. As the market value of mAbs increases in the biopharma industry, the demand for high quantities is met by upscaled production using bioreactor systems. Thus, disposable, porous matrices called cryogels have gained the primary focus for adherent support in the proliferation of hybridoma cells. Methods: In this study, a gelatin-immobilized polyhydroxyethylmethacrylate-based cryogel material (disc-shaped, 9 mL bed volume) was synthesized, and a mini-bioreactor set up developed for culturing hybridoma cells to produce mAbs continuously. The hybridoma clone, 1B4A2D5, secreting anti-human serum albumin monoclonal antibodies, was immobilized in the cryogel matrix (2 discs, 18 mL bed volume). Results: The hybridoma cells were attached to the matrix within 12 h after inoculation, and the cells were in the lag phase for seven days, where they were secreted mAb into the circulation medium. During the initial exponential phase, the glucose consumption, lactic acid production, and mAb production were 3.36 mM/day, 3.67 mM/day, and 55.61 µg/mL/day, respectively. The medium was refreshed whenever the glucose in the media went below 50% of the initial glucose concentration. The cryogenic reactor was run continuously for 25 days, and the mAb concentration reached a maximum on the 17th day at 310.59 µg/mL. Conclusion: The cumulative amount of mAbs produced in 25 days of running was 246 µg/mL, 7.7 times higher than the mAbs produced from T-flask batch cultivation. These results demonstrate that the developed polyhydroxyethylmethacrylate-based cryogel reactor can be used efficiently for continuous mAb production.
Interaction of Exosomal MicroRNA and Oxidative Stress in the Pathogenesis of Colitis-Associated Cancer
Authors: Li Yifan , Li Huanyu , Cui Manli , Zhou Ying , Zhang Mingzhen , Zhang Mingxin
Published: August 2024

Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. In recent years, the incidence of CAC has increased worldwide. Oxidative stress (OS) is involved in the development of CAC through oxidative damage to biomolecules or activation of inflammatory signaling pathways. Exosomes are extracellular vesicles that act as messengers to deliver signals and macromolecules to target cells, making them important mediators of intercellular communication and exchange of biologically active molecules between cells. MicroRNAs (miRNAs) carried by exosomes regulate the pro- and anti-inflammatory pathways of OS and play a key role in communication between OS and cancer cells. This review describes the correlation between OS and exosomal miRNAs with the goal of identifying a novel therapeutic method for CAC.
Bulimia Nervosa and Depression, from the Brain to the Gut Microbiota and Back
Authors: Romeo Marcello , Cavaliere Gina , Traina Giovanna
Published: August 2024

Bulimia nervosa (BN) is a condition marked by a typical cyclical behavioural activity, characterized by restrictions, binges and vomiting, as well as a disturbance of the emotional value of food. Food stimuli acquire excessive relevance, giving rise to a succession of states of excitement and anxiety. The depressive condition accompanies very often BN. Most people with BN also experience one or more anxiety disorders. The aim of the review is to identify a link at a central and peripheral level that connects an eating disorder with a mood state. Altered nervous mechanisms are involved in BN. Among the cerebral areas, the insula is functionally compromised in BN. The insula is also implicated in depressive states. The insula is the primary gustatory cortex, where gustatory sensory information such as taste discrimination and higher cognitive functions such as food anticipation and reward are processed. The insula is anatomically connected to a wide range of cortical, limbic and paralimbic structures, and functionally implicated in high-order cognition, emotional responses, and empathic processes. The insula plays a crucial role in empathy, or in the ability to share the emotional states of others, and in particular negative emotions. In fact, the insular cortex is also activated in conditions of anxiety and depression. One of the pathophysiological factors that influences bulimia and depression is the composition of gut microbiota, as there is a strong association between the microbial signature and the brain function. Gut dysbiosis condition may contribute to the development of eating disorders, including BN. Dysbiosis may promote intestinal inflammation, alter gut permeability, and trigger immune reactions in the hunger/satiety regulation center contributing to the pathophysiological development of eating disorders. From this emerges the importance of adequate probiotic integration as a preventive and/or therapeutic tool in these pathologies.
Predictors and Prognostic Factors of Heart Failure with Improved Ejection Fraction
Authors: Wu Nilian , Lang Xueyan , Zhang Yanxiu , Zhao Bing , Zhang Yao
Published: August 2024

Background: Heart failure with reduced ejection fraction (HFrEF) patients who have improved ejection fraction have a better prognosis than those with persistently reduced ejection fraction. This study aimed to analyze the predictors for progression of patients with HFrEF to heart failure with improved ejection fraction (HFimpEF), as well as their characteristics and analyze predictors for prognosis. Methods: A retrospective analysis was conducted on 1251 patients with HFrEF at baseline, who also had a second echocardiogram ≥3 months. After left ventricular ejection fraction (LVEF) reassessment, patients were separated into the HFimpEF group (n = 408) and the persistent HFrEF group (n = 611). The primary endpoint was a composite of cardiovascular death or heart failure hospitalization. Results: Multivariate logistic regression showed that without history of alcohol consumption (OR: 0.47, 95% CI: 0.28–0.78), non-New York Heart Association (NYHA) class III–IV (OR: 0.28, 95% CI: 0.15–0.52), without dilated cardiomyopathy (OR: 0.47, 95% CI: 0.26–0.84), concomitant hypertension (OR: 1.53, 95% CI: 1.02–2.29), β-blockers use (OR: 2.29, 95% CI: 1.54–3.43), and lower uric acid (OR: 0.999, 95% CI: 0.997–1.000) could predict LVEF improvement. Kaplan-Meier curves demonstrated that HFimpEF patients had a significantly lower incidence of adverse events than HFrEF patients (log Rank p < 0.001). Multivariate Cox regression found that older age (HR: 1.04, 95% CI: 1.02–1.06), NYHA class III–IV (HR: 2.25, 95% CI: 1.28–3.95), concomitant valvular heart disease (HR: 1.98, 95% CI: 1.01–3.85), and higher creatinine (HR: 1.003, 95% CI: 1.001–1.004) were independent risk factors for the primary endpoint in HFimpEF patients. Conclusions: HFrEF patients without a history of alcohol consumption, non-NYHA class III–IV, without dilated cardiomyopathy, concomitant hypertension, β-blockers use, and lower uric acid were more likely to have LVEF improvement. Although the prognosis of HFimpEF patients was better than that of HFrEF patients, older age, NYHA class III–IV, concomitant valvular heart disease, and higher creatinine were still risk factors for cardiovascular events in HFimpEF patients.
Current Antithrombotic Treatments for Cardiovascular Diseases: A Comprehensive Review
Authors: Galanti Kristian , Di Marino Mario , Mansour Davide , Testa Sabrina , Rossi Davide , Scollo Claudio , Magnano Roberta , Pezzi Laura , D'Alleva Alberto , Forlani Daniele , Vitulli Piergiusto , Paloscia Leonardo , Ricci Fabrizio , Renda Giulia , Gallina Sabina , Di Marco Massimo
Published: August 2024

Antithrombotic therapies (ATT) play a pivotal role in the management of cardiovascular diseases, aiming to prevent ischemic events while maintaining a delicate balance with the patient’s bleeding risk. Typically, ATT can be classified into antiplatelet and anticoagulant therapies. Their application spans a broad spectrum of cardiovascular conditions, ranging from ischemic heart disease to atrial fibrillation, encompassing venous thromboembolisms and innovative structural interventional cardiology procedures. The global burden of cardiovascular diseases is steadily increasing, often giving rise to overlapping clinical presentations. Accordingly, the adoption of combined pharmacological approaches becomes imperative, potentially disrupting the delicate equilibrium between ischemic and bleeding risk, thus leading to nuanced pharmacotherapeutic pathways. In this context, contemporary investigations strive to identify a convergence point that optimizes the duration of medical therapy while addressing the need for antithrombotic effects, especially in the context of ischemic heart disease. This review aims to comprehensively revisit the main antithrombotic strategies in cardiovascular diseases, with the intention of enhancing a systematic approach which is key for the effective clinical management of these patients. Also, the review will examine the most impactful studies that have established the groundwork for current scientific evidence, with acknowledgement of special populations. Finally, we will cast a gaze into the future of this dynamic and evolving research field, exploring forthcoming perspectives and advancements.
A Systematic Review and Meta-Analysis of 35,409 Patients Undergoing PCI versus CABG for Unprotected Left Main Coronary Artery Diseases
Authors: Liu Hao , Li Dongdong , Gao Chuncheng , Dai Huimiao , Kang Lin , Zhang Mingming , Yun Chen , Guo Wangang
Published: August 2024

Background: Patients with unprotected left main (UPLM) disease who underwent percutaneous coronary intervention (PCI) were found to have inconsistent results compared to those treated with coronary artery bypass grafting (CABG). Methods: We identified and enrolled randomized controlled trials (RCTs) and observational studies (OSs) comparing PCI versus CABG for UPLM disease. A meta-analysis was performed using Stata 17.0. The primary endpoints were major adverse cardiovascular and cerebrovascular events (MACCEs). Additionally, all-cause death, cardiac death, myocardial infarction (MI), stroke, target vessel revascularization (TVR), and stent thrombosis (ST) were included as secondary endpoints. The odds ratios and 95% confidence intervals (CIs) were calculated. Sensitivity analyses were implemented if I2 > 50% or p < 0.01. Publication bias analysis was conducted if more than 10 studies were included. Results: A total of 5 RCTs and 18 OSs involving 35,409 patients were included. The CABG strategy had a significantly lower incidence of MACCEs, primarily due to TVR. A significantly lower stroke rate was observed with the PCI strategy, as well as a significantly lower all-cause death, cardiac death, MI, and ST rate compared with the CABG strategy. Conclusions: MACCE rates were significantly lower in patients who underwent CABG, primarily due to TVR, but stroke rates were higher. RCTs with different study types need further investigation to confirm the most effective strategy.
Papillary Muscle Maneuvers: Pathophysiology-based Approach in Secondary Mitral Regurgitation
Authors: Girdauskas Evaldas , Stock Sina , Favot Elisa , Luani Blerim , Sequeira-Gross Tatiana , Dumps Christian , Stumm Maria von , Owais Tamer , von Scheidt Wolfgang
Published: August 2024

The treatment of secondary mitral regurgitation (SMR) remains challenging despite the implementation of modern heart failure medication and established catheter-based techniques. Only a subgroup of SMR patients benefit from mitral valve (MV) intervention, and the long-term prognostic benefit of different therapeutic approaches in SMR remains controversial. A literature search was conducted through PubMed and Embase databases to identify relevant studies addressing the pathophysiological background for papillary muscle maneuvers in SMR and currently available surgical techniques. Furthermore, the studies evaluating patients’ selection criteria for papillary muscle maneuvers were specifically considered. Articles were selected based on quality and relevance. Over the last two decades, papillary muscle maneuvers have evolved as a pathophysiology-based treatment strategy to address left ventricular (LV) remodeling in SMR. In particular, patients with severe leaflet tenting and moderate heart failure phenotype seem to benefit most from papillary muscle maneuvers that improve LV geometry and thereby the durability of MV repair. We conclude that papillary muscle maneuvers are an evolving pathophysiology-based treatment strategy of ventricular SMR which target papillary muscle displacement due to LV remodeling.
Exchange Property in Double Edge Resolving Partition Sets and Its Use in City Development
Authors:   Department of Mathematics, Riphah International University, Lahore, Pakistan, Ali Sikander , Jamil Muhammad Kamran ,   Department of Mathematics, Riphah International University, Lahore, Pakistan
Published: August 2024

The exchange property in double-edge resolving partition sets is examined in this article, along with some real-world applications to city buildings. In graph theory, double-edge resolving sets are essential because they provide information on optimizing transportation and urban infrastructure. When utility units are switched out, the exchange property ensures the system is efficient and still works. City planners can create more adaptable and durable urban layouts by using this feature, guaranteeing that the best routes and shortest distances remain intact in various setups. We show how the exchange property in double-edge resolving partition sets can improve traffic management, emergency response systems, and overall urban planning through theoretical analysis and real-world case studies. The findings highlight the capability of graph-theoretical techniques in addressing complicated urban planning challenges, ultimately contributing to smarter, extra-sustainable town development. This study highlights the potential of advanced graph-theoretical concepts to address complex urban development challenges, contributing to the creation of smarter, more adaptive cities.
Perception of the Secondary Level Students Regarding the Examination Ethics
Authors: Panday Nikesh
Published: August 2024

In the study entitled Perception of the secondary level students regarding the examination ethics in Nepal, the Grade XII students expressed their opinions on examination ethics. The Grade XII students from a school in the Kathmandu district were randomly chosen to participate in the survey. The study found that the students were aware of exam ethics. They agreed that sustaining examination ethics in Nepal is complicated. 51.7% of the students favored implementing rules to follow examination ethics. 89.7% of the students decided on a fair examination.40.5% said their parents, teachers, and stakeholders favored cheating, whereas 59.5% followed the examination ethics. However, maintaining the ethics includes being aware of impersonation and cheating. Most students perceived the examination as complex, so keeping ethics was hard. According to the study’s conclusions, the government and educational institutions must act to address these issues and advance examination ethics.
Kajian Dampak Degradasi Sungai Progo Studi Kasus Penggalan Sungai Progo di Daerah Wiyu, Pundak Wetan dan Jomboran Yogyakarta
Authors: Nugroho Nandra , Febriansanu Dicko Rizky
Published: August 2024

Penurunan atau degradasi pada penampang dasar Sungai Progo memang tidak bisa dilihat secara langsung tetapi dampak yang ditimbulkan akibat degradasi tersebut bisa diamati mulai dari penurunan muka air tanah hingga menyebabkan lereng – lereng pada tebing sungai menjadi rawan longsor. Salah satu dampak penurunan dasar Sungai Progo biasa diamati di Daerah Wiyu, Pundak Wetan dan Jomboran. Diindikasikan penurunan dasar sungai terjadi karena alih fungsi sungai menjadi kawasan pertambangan pasir dan batu yang dilakukan dari badan sungai. Tingkat bahaya erosi di lokasi penelitian masuk kategori moderat, hal ini menjadi pertimbangan besarnya erosi yang terjadi akan menimbulkan bahaya terjadinya longsor. Dari hasil analisis dan penggabungan peta penampang daerah Wiyu, Pundak Wetan dan Jomoran dapat dilihat penurunan muka air tanah berada pada sekitaran aliran Sungai Progo dengan tingkat penurunan kedalaman 5 – 10 meter.
Fitoremediasi Memanfaatkan Tanaman Coontail untuk Menurunkan Kadar Timbal (Pb) menggunakan Sistem Batch
Authors: Sulaiman Achmad , Nilandita Widya , Suprayogi Dedy
Published: August 2024

Pencemaran lingkungan yang disebabkan oleh limbah semakin banyak adanya seiring dengan banyaknya industri yang ada di Indonesia. Perlu adanya pengolahan limbah alternatif yang digunakan untuk mengurangi pencemaran lingkungan. Fitoremediasi merupakan alternatif pengolahan yang dapat digunakan untuk mengolah limbah yang mengandung logam berat karena pada pengolahan ini memanfaatkan tanaman untuk menyerap logam berat yang ada pada limbah. Tujuan dari penelitian ini yaitu untuk mengetahui efisiensi penyerapan tanaman Coontail (Ceratophyllum demersum) dalam melakukan proses fitoremediasi air limbah yang mengandung timbal (Pb) dan untuk mengetahui apakah terdapat perbedaan yang dipengaruhi oleh variasi jumlah tanaman yang digunakan dalam menurunkan kadar Pb. Dalam penelitian eksperimental ini menggunakan variasi jumlah tanaman sebanyak 5 dan 10 tanaman yang digunakan dalam fitoremediasi dengan sistem batch, sedangkan untuk waktu fitoremediasi selama 10 hari. Hasil penelitian ini menunjukkan bahwa pada masing-masing reaktor memiliki penyerapan yang berbeda-beda yaitu pada reaktor limbah logam Pb dengan 5 tanaman dengan hasil rata-rata sebesar 83,7% sedangkan hasil pada reaktor dengan 10 tanaman dengan hasil rata-rata sebesar 86,8%. Berdasarkan hasil uji Kruskal Wallis nilai Asymp.sig tidak melebihi 0,05 yang berarti tidak ada perbedaan variasi jumlah tanaman terhadap penurunan kadar Pb.
Evaluasi Sebaran Salinitas Jaringan Irigasi Tambak Sei Teras Kalimantan Tengah
Authors: Duhita Anselma Diksita Prajna , Rahardjo Adam Pamudji , Istiarto Istiarto
Published: August 2024

Daerah Irigasi Tambak (DIT) Sei Teras dimanfaatkan untuk budidaya udang vaname (Litopenaeus vannamei) dan termasuk area pengembangan food estate. Produktivitas DIT Sei Teras masih rendah karena faktor kualitas air, termasuk salinitas sehingga perlu dievaluasi. Titik-titik sampel pengukuran salinitas tersedia, tetapi sebaran salinitas diperlukan untuk mengetahui distribusi salinitas secara komprehensif. Penelitian ini bertujuan untuk mengevaluasi sebaran salinitas di DIT Sei Teras sebagai langkah awal upaya meningkatkan produktivitas. Evaluasi sebaran salinitas dilakukan dengan simulasi pemodelan menggunakan perangkat lunak HEC-RAS. Prosedur penelitian yakni penyesuaian data geometri, kalibrasi model, simulasi aliran tidak permanen, dan simulasi kualitas air. Hasil simulasi sebaran salinitas dievaluasi berdasarkan pedoman yang berlaku. Nilai n Manning hasil kalibrasi model yaitu 0,03. Sebaran salinitas pada saluran primer menunjukkan salinitas minimal tingkat budidaya semi intensif (10 ppt) tercapai hingga jarak 4,7 km dan 5,9 km dari muara untuk Saluran Primer Sei Teras dan Pelampai. Sebaran salinitas pada saluran sekunder menunjukkan 80% ruas Saluran Sekunder Cemara Labat, 56% ruas Saluran Sekunder Pelampai, dan 68% ruas Saluran Sekunder Sei Teras memenuhi salinitas minimal untuk tingkat budidaya semi intensif. Sebaran salinitas di DIT Sei Teras bervariasi sehingga upaya peningkatan sebaran salinitas diperlukan guna meningkatkan produktivitas.
“The Spectacle of Amish Attacking Amish”: Framing Dichotomies in News Coverage of a Religious Hate Crime
Authors: Carey Michael Clay
Published: August 2024

This study employs qualitative textual analysis to examine framing dichotomies in mainstream local news coverage of a series of attacks on Amish residents in Ohio carried out by a breakaway Amish group in 2011. Using Stuart Hall’s understanding of narrative binaries and the anthropological concept of the other within the other, the study argues portrayals of both the victims and the perpetrators of those crimes employed common stereotypes of Amish groups. The study describes the negative consequences of the “good Other” representation applied to the victims of the crimes and argues for more nuanced news coverage of non-mainstream religious groups.
Sintering Concepts Relevant to Greater Density and Improved Properties
Authors: German Randall M.
Published: August 2024

This chapter describes how forces and temperatures generated during sintering influence particle bonding, grain growth, shrinkage, and densification as well as bulk material properties. It explains how density, a good predictor of mechanical and electrical properties, can be controlled by proper selection of sintering time, temperature, and particle size for various steels, ceramics, and tungsten and titanium alloys.
Additive Manufacturing in the Automotive, Medical, and Construction Industries
Authors: Gadgil Anurag , Jain Pushpdant
Published: August 2024

This chapter assesses the state of 3D printing among automakers, medical device manufacturers, and construction companies.
Role of Powder Metallurgy Industries in Various Sectors―Part 2
Authors: Binal Gulfem , Ozkan Dervis , Ozgurluk Yasin , Yilmaz Sefa Erdem , Karaoglanli Abdullah Cahit
Published: August 2024

This chapter explains how powder metallurgy technologies are being leveraged for the production of automotive components, electric motors, rare-earth permanent magnets, and the infrastructure for high-speed rail transport.
Exploring factors affecting activities of daily living in patients with osteoporotic vertebral fractures managed conservatively: a post-hoc analysis of a prospective cohort study
Authors: Funayama Toru , Tatsumura Masaki , Fujii Kengo , Shibao Yosuke , Okuwaki Shun , Sakashita Kotaro , Sunami Takahiro , Inomata Kento , Gamada Hisanori , Miura Kousei , Noguchi Hiroshi , Takahashi Hiroshi , Koda Masao , Yamazaki Masashi
Published: August 2024

Study Design: A post-hoc analysis of a prospective cohort study.Purpose: This study aimed to identify factors at the time of injury associated with declining activities of daily living (ADLs) in the chronic phase of osteoporotic vertebral fractures (OVFs) managed conservatively.Overview of Literature: Although a conservative approach is the treatment of choice for OVFs, ADLs do not improve or eventually decrease in some cases. However, the risk factors for ADL decline after the occurrence of OVFs, particularly the difference between those with or without initial bed rest, are unknown.Methods: A total of 224 consecutive patients with OVFs aged ≥65 years who received treatment within 2 weeks after the occurrence of injury were enrolled. The patients were followed up for 6 months thereafter. The criteria for evaluating the degree of independence were applied to evaluate ADLs. Multivariable analysis with a logistic regression model was performed to evaluate the risk factors for ADL decline.Results: In total, 49/224 patients (21.9%) showed a decline in ADLs. Of these, 23/116 patients (19.8%) in the rest group and 26/108 patients (24.1%) in the no-rest group experienced a decline in ADLs. In the logistic regression analyses, a diffuse low signal on T2- weighted magnetic resonance imaging (MRI) (odds ratio, 5.78; 95% confidence interval, 2.09–16.0; p=0.0007) and vertebral instability (odds ratio, 3.89; 95% confidence interval, 1.32–11.4; p=0.0135) were identified as independent factors in the rest and no-rest groups, respectively.Conclusions: In patients with acute OVFs, a diffuse low signal on T2-weighted MRI and severe vertebral instability were independently associated with ADL decline in patients treated with and without initial bed rest, respectively.
FUNCTIONAL AND SPATIAL INTERACTION OF EXISTING AND NEW PARTS OF THE CITY STRUCTURE
Authors: Kucherenko Оlexander , Obodianska Olha , Babii Ihor , Denysenko Vladyslav
Published: August 2024

The article examines the issues of structural and planning formation and development of urban agglomerations in new territorial and economic conditions. Taking into account the trends and forecasting the development of these changes is the main urban planning prerequisite for the formation of the planning foundations of a large city and the group system as a whole. Improvement of the functional and planning structure of large and largest cities is connected with the transition from extensive to intensive factors of their development. On this basis, the negative characteristics of the planning structure of large cities, which inhibit their effective development, must be overcome.
Expanded territories of cities, overdensification of their central areas, difficulties in transport connections, separation from the natural environment, and excessive concentration of the urban population are exacerbated by the discrepancy between the principles of the formation of the planning structure, designed for the limited scope of functions, connections and sizes of territories, and new conditions of development associated with with the sharply growing socio-economic needs of the development of populated cities, the interaction between them, the concentration of production, the improvement of transport equipment and other factors that involve the sphere of action of intensive urban processes, large areas that gravitate towards the city.
The existing nature of the functioning of large cities and their zones of influence leads to the growth of centripetal tendencies, which are formed, on the one hand, on the scale of the city itself, on the other - on the scale of zones that gravitate towards it. The density of objects in the central part of a large city, adjacent to it, increases, the density and volumes of center-forming functions, which attract significant contingents of the population, increase, as a result of the inertia of the build-up of previously created infrastructures.
DECISION-MAKING SUPPORT SYSTEMS IN CONSTRUCTION PROJECTS BASED ON BAYES NETWORKS
Authors: Osypenko Roman , Lialiuk Olena , Melnyk Denys
Published: August 2024

The work presents support systems for decision-making in conditions of uncertainty or incomplete information inconstruction projects. With the help of integrated databases, the minimum level of information is determined, which can beused both for data extrapolation and for filling decision-making models. In order to estimate the probability of parameters, forexample, the cost or duration of their compilation when applying BIM modeling, a hypothesis calculation was carried out, whichis based on a probabilistic graph model of networks Bayes.On the one hand, BIM is a necessary technique both for the construction of new buildings, and on the other hand, itreceives particular attention and interest from owners of large construction funds who want to take advantage of buildinginformation modeling to have a coordinated system for joint use during construction, modernization and operation of buildingsand structures.Especially in a process related to the management and maintenance of large construction stocks, it involves the processingof uncertain information in BIM. When working with existing buildings, due to the absence and/or incomplete availability ofdocumentation, which entails significant investments in terms of time and additional costs.Therefore, to represent the reliability of existing data, it is worth introducing a tool based on a graphical probabilisticBayesian network model that offers valid decision support under uncertainty.
Plasma Amino Acid Profiles and Clinical Outcome in Patients with Traumatic Brain Injury: A Study Protocol
Authors: Gheflati Alireza , Shahraki Jazinaki Mostafa , Nikbaf-Shandiz Mahlagha , Rahbarinejad Pegah , Rezaee Hamid , Eslami Saeid , Khadem-Rezaian Majid , Sedaghat Alireza , Nematy Mohsen , Shadnoush Mahdi , Jafarzadeh Esfehani Ali , Keyfi Fatemeh , S. Clayton Zachary , Norouzy Abdolreza
Published: August 2024

Background: The most common cause of cognitive and behavioral impairments, disability, and mortality around the world is traumatic brain injury (TBI). The imbalance between cerebral metabolism and inflammation leads to protein breakdown and induces altered concentrations of serum amino acids, which can serve as a diagnostic and prognostic sign in patients with TBI. This study aimed to examine the alterations in plasma amino acid concentrations and their relation to clinical outcomes in patients with TBIs. Materials and Methods: At completion, this study will assess 107 patients suffering from TBI aged 18 to 65. Plasma amino acid concentrations, anthropometric indices, and clinical outcome parameters including Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA), Nutrition Risk in the Critically ill (Nutric) score, Glasgow coma scale (GCS), Intensive Care Unit (ICU) discharge time, mechanical ventilator duration, and mortality rate will be assessed at the beginning of the study, day 7, and day 14. Conclusion: This longitudinal study will provide evidence for further clinical trials and observational studies on amino acid supplementation and TBI. The results of this study could inform future treatment strategies for TBI patients.
Self-Care Behaviors in Pregnant Women with Gestational Diabetes
Authors: Rahimi Malihe , Keikha Hossein , GhorbaniNia Rahil , Azizi Younes , Ovaisi Zahra , Mohammadian Shima , Aminipour Faezeh
Published: August 2024

Gestational diabetes (GD) is a type of diabetes that is considered a prevalent health issue that has been reported to represent an increasing trend in the past two decades. It is demonstrated that the prevalence of GD is irrespective of the country’s income status and is associated with complications of maternal and fetal due to maternal hyperglycemia. Although no specific treatment for GD has been established, various studies have suggested self-care as a potential strategy. Therefore, the current study aimed to review the effectiveness of self-care in pregnant women with GD. The findings revealed that increasing awareness of the pathophysiology and consequences of GD along with improving self-care behaviors such as monitoring blood glucose levels, changing lifestyle, and maintaining mothers’ health can potentially improve indicators related to diabetes. However, further studies with larger sample sizes and evaluation of related clinical/laboratory indicators in this content appear to be crucially required to confirm current understanding.
Unveiling Cardiovascular Outcomes: A Comparative Analysis of CABG Recipients versus Non-CABG Patients in the Management of Acute Coronary Syndrome (ACS)
Authors: Aslanabadi Naser , Separham Ahmad , Golshani Hormoz , Javanshir Elnaz , Parizad Razieh , Ahmadzadehpournaky Ahmad
Published: August 2024

Background: The history of bypass surgery for coronary arteries and subsequent coronary angioplasty is a crucial and vital issue for patients with acute coronary syndrome (ACS). This study aims to investigate and compare the occurrence of cardiovascular events in patients with a history of Coronary Artery Bypass Grafting (CABG) versus those without such a history, specifically focusing on individuals diagnosed with ACS. Materials and Methods: This cohort study was conducted at Madani Hospital in Tabriz, Iran. Patients diagnosed with ACS who were hospitalized and underwent Percutaneous Coronary Intervention (PCI) from the beginning of 2018 to the beginning of 2020 were included. The records for follow-up regarding mortality and cardiovascular events were documented for the next three years (2020 to 2023). Subsequently, patients were categorized into two groups: those with a history of CABG and those without a history of CABG. Patients of each study group were divided into two groups: ST-segment elevation acute coronary syndrome (STEA)CS/primary PCI and non-ST-segment elevation acute coronary syndrome (NSTEACS)/PCI, a total of approximately 473 cases were collected. The study groups were compared in terms of in-hospital and long-term cardiovascular events as well as other clinical outcomes.​ Results: A comparison of hospital and long-term events between the CABG group and the control group demonstrated a significant difference only in cases of recurrent myocardial infarction (MI)/ACS in long-term events (P=0.001). Additionally, comparing hospital and long-term events in the CABG group and the STEACS/NSTEACS control group revealed a significant difference only in cases of recurrent MI/ACS in long-term events (P=0.05). Conclusion: Patients with a history of CABG may face a higher risk of cardiovascular events, especially in recurrent MI/ACS. A thorough examination and closer monitoring of this patient group are needed to ensure improvement and mitigate the risks associated with potential complications arising from previous CABG surgeries.
Comparison of Thyroid Gland Sonography Index with Serum Antithyroid Peroxidase, Antithyroglobulin, and Thyroid Function Tests in Patients with Hashimoto Thyroiditis
Authors: Eftekharian Fatemeh , Ranjbar Omrani Gholamhossein , Dabbaghmanesh Mohammad Hossein , Sahraei Reza , Behnam Mohammad Ali , Bakhshayeshkaram Marzieh , Dabbaghmanesh Mohammad Mahdi
Published: August 2024

Background: Ultrasound examination of the thyroid has emerged as a useful diagnostic and prognostic tool, along with measuring serum titers of anti-thyroid peroxidase (TPO), anti-thyroglobulin (Tg), and thyroid hormones, in patients with Hashimoto's thyroiditis. So, we aimed at considering correlations of ultrasonographic, antibodies, and thyroid hormone levels. Materials and Methods: A total of 149 patients (118 females, 31 males; aged 18–60 years; mean age: 38.60 ± 8.03 years) who were diagnosed with Hashimoto's thyroiditis were enrolled in the study. The blood sample was taken to measure serum titers of free T3 (FT3) and T4 (FT4), TSH, anti-TPO, and anti-Tg antibody titers. The thyroid sonography of each patient was classified into one of the five grades by real-time ultrasound (US) based on echogenicity, thyroid size, and thyroid pattern. We evaluated whether there was a correlation between thyroid characteristics observed via ultrasound and serum levels of thyroid hormones, anti-TPO antibodies, and anti-Tg antibodies. Results: Nodular structures were detected in 54 (36.2%) patients (38 micro-nodular and 16 macro-nodular). Echogenicity was recorded as isoechoic in 15(10.07%) and hypoechoic in 119 (79.87%) subjects. Euthyroid ‎subjects had significantly thicker isthmus than overt and subclinical hypothyroid patients (P=0.018). Mean serum TSH, anti-Tg, and anti-TPO antibody titers showed a significant increase in patients with macro-nodules compared to those with micro-nodules and individuals without nodules (P<0.05). The thickness of the isthmus had a significant negative correlation with FT4 (P=0.046; r=0.11) and FT3 (P=0.017; r=0.15), respectively. Thyroid autoantibodies had positive significant correlations with different parameters of thyroid volume (P<0.05). Conclusions: Thyroid US findings, in addition to serum anti-Tg and anti-TPO antibody titers, might be correlated with the severity and extent of Hashimoto's thyroiditis, but further evaluations are needed.
Persepsi Pentingnya Inovasi Dalam Organisasi Atau Perseorangan
Authors: Romli Mochamad Edwar
Published: August 2024

ABSTRACTÂ Innovation is a new group, although there is no new column actually that discovery is only an imitation or adaptation of an existing one. Or there are those who claim that the new naming or innovation is only a combination of existing results. However it was concluded that innovation is important in organizations or change. With the innovation can lead to change. Therefore the problem formulation in this paper is why is innovation important in an organization or change? in this connection the purpose of writing is to find out why innovation is important in an organization or change.Keywords: Innovation, OrganizationÂ ABSTRAKÂ Inovasi merupakan suatu kelompok baru, walaupun ada kolomnya tidak benar-benar baru penemuan itu hanya merupakan peniruan atau adaptasi dari yang sudah ada. Atau ada yang menyatakan peneriamaan baru atau inovasi itu hanya merupakan sautu hasil kombinasi dari yang sudah ada. Walaupun demikian diakhiri bahwa inovasi itu penting dalam organisasi atau perubahan.Dengan adanya inovasi dapat membawah perubahan. Oleh karena itu rumusan masalah dalam penulisan ini adalah mengapa inovasiÂ  penting dalam suatu organisasiÂ  atau perubahan ? sehubungan dengan ini tujuan penulisan adalah untuk mengetahui mengapa inovasi penting dalam suatu organisasi atau perubahan.Kata Kunci : Inovasi, Organisasi
Pengaruh Pengawasan Dan Kemampuan Kerja Terhadap Kinerja Pegawai Kejaksaan Tinggi Sumatera Selatan
Authors: Ruslan Ruslan , Kurbani Adie
Published: August 2024

ABSTRACTÂ The problem of this research is the lack of a supervisory role that is not yet solid, and the goal is not yet achieved in the work ability to monitor and mobilize employees and the employee's performance is not optimal. This study aims to determine "The Effect of Supervision and Work Ability on Employee Performance of the South Sumatra High Prosecutor's Office".This research was conducted at the South Sumatra Prosecutor's Office. With a population of 75 people with a sample of all employees who live 75 people. The data collection techniques in this study were questionnaires and documentation. Data were analyzed using normality test, multicoloniarity, and heteroscedasticity test. And using simple linear regression hypothesis testing and multiple linear regression (determination, t test and f test).Based on the data analysis, it is known that the variables of Supervision and Work Ability jointly have a significant influence on the performance of the South Sumatra High Prosecutor's Office with a significance value of 0.000 (0.000 <0.05). Partially Work Supervision (X1) has a significant effect on performance (Y) with a significance value of 0.000 (0.000 <0.05). Work Ability (X2) has a significant effect on performance (Y) with a significant value of 0.000 (0.000 <0.05), it can be concluded that partially selection (X2) has a positive and significant effect on performance (Y).Â Keywords: Work Supervision, Work Ability, and Employee PerformanceÂ Â ABSTRAKÂ Masalah penelitian ini adalah kurangnya peranan pengawasan yang belum mantap, dan belum tercapainya tujuan dalam kemampuan kerja untuk memantau dan menggerakan pegawainya serta kinerja pegawai yang belum optimal. Penelitian ini bertujuan untuk mengetahui â€Pengaruh Pengawasan dan Kemampuan Kerja Terhadap Kinerja Pegawai Kejaksaan Tinggi Sumatera Selatanâ€. Penelitian ini dilakukan di Kejaksaan Tinggi Sumatera Selatan. Dengan populasi 75 orang dengan sampel seluruh pegawai yang berjumah 75 orang. Teknik pengumpulan data pada penelitian adalah kuesioner dan dokumentasi. Data dianalisis dengan menggunakan uji normalitas, multikoloniaritas, dan uji heteroskedasitas. SertaÂ  menggunakan pengujian hipotesis regresi linier sederhana dan regresi linier berganda (determinasi, uji t dan uji f). Berdasarkan analisis data diketahui secara bersama-sama (simultan) variabel Pengawasan dan Kemampuan Kerja memiliki pengaruh signifikan terhadap Kinerja Pegawai Kejaksaan Tinggi Sumatera Selatan dengan nilai signifikasi 0,000 (0,000 < 0,05). Secara parsial Pengawasan Kerja (X1)Â  mempunyai pengaruh yang signifikan terhadap Kinerja (Y) denganÂ  nilai signifikasi 0,000 (0,000 < 0,05). Kemampuan Kerja (X2) mempunyai pengaruh signifikan terhadap Kinerja (Y) dengan nilai signifikan 0,000 (0,000 <0,05), maka dapat disimpulkan bahwa secara persial seleksi (X2) berpengaruh positif dan signifikan terhadap kinerja (Y).Â Kata Kunci: Pengawasan Kerja, Kemampuan Kerja, dan Kinerja Pegawai