bluuebunny/crossref_metadata_2025 huggingface dataset:
DermACELL: Human Acellular Dermal Matrix Allograft
Authors: Cole Windy E.
Published: March 2016

Diabetes often causes ulcers on the feet of diabetic patients. A 56-year-old, insulin-dependent, diabetic woman presented to the wound care center with a Wagner grade 3 ulcer of the right heel. She reported a 3-week history of ulceration with moderate drainage and odor and had a history of ulceration and osteomyelitis in the contralateral limb. Rigorous wound care, including hospitalization; surgical incision and drainage; intravenous antibiotic drug therapy; vacuum-assisted therapy; and a new room temperature, sterile, human acellular dermal matrix graft were used to heal the wound, save her limb, and restore her activities of daily living. This case presentation involves alternative treatment of a diabetic foot ulcer with this new acellular dermal matrix, DermACELL.
Transgenerational effects enhance specific immune response in a wild passerine
Authors: Broggi Juli , Soriguer Ramon C. , Figuerola Jordi
Published: March 2016

Vertebrate mothers transfer diverse compounds to developing embryos that can affect their development and final phenotype (i.e., maternal effects). However, the way such effects modulate offspring phenotype, in particular their immunity, remains unclear. To test the impact of maternal effects on offspring development, we treated wild breeding house sparrows (Passer domesticus) in Sevilla, SE Spain with Newcastle disease virus (NDV) vaccine. Female parents were vaccinated when caring for first broods, eliciting a specific immune response to NDV. The immune response to the same vaccine, and to the PHA inflammatory test were measured in 11-day-old chicks from their following brood. Vaccinated chicks from vaccinated mothers developed a stronger specific response that was related to maternal NDV antibody concentration while rearing their chicks. The chicks’ carotenoid concentration and total antioxidant capacity in blood were negatively related to NDV antibody concentration, whereas no relation with PHA response was found. Specific NDV antibodies could not be detected in 11-day-old control chicks from vaccinated mothers, implying that maternally transmitted antibodies are not directly involved but may promote offspring specific immunity through a priming effect, while other immunity components remain unaffected. Maternally transmitted antibodies in the house sparrow are short-lived, depend on maternal circulation levels and enhance pre-fledging chick specific immunity when exposed to the same pathogens as the mothers.
Investigation of the effects of estrogen on skeletal gene expression during zebrafish larval head development
Authors: Pashay Ahi Ehsan , Walker Benjamin S. , Lassiter Christopher S. , Jónsson Zophonías O.
Published: March 2016

The development of craniofacial skeletal structures requires well-orchestrated tissue interactions controlled by distinct molecular signals. Disruptions in normal function of these molecular signals have been associated with a wide range of craniofacial malformations. A pathway mediated by estrogens is one of those molecular signals that plays role in formation of bone and cartilage including craniofacial skeletogenesis. Studies in zebrafish have shown that while higher concentrations of 17-βestradiol (E2) cause severe craniofacial defects, treatment with lower concentrations result in subtle changes in head morphology characterized with shorter snouts and flatter faces. The molecular basis for these morphological changes, particularly the subtle skeletal effects mediated by lowerE2concentrations, remains unexplored. In the present study we address these effects at a molecular level by quantitative expression analysis of sets of candidate genes in developing heads of zebrafish larvae treated with two differentE2concentrations. To this end, we first validated three suitable reference genes,ppia2,rpl8andtbp, to permit sensitive quantitative real-time PCR analysis. Next, we profiled the expression of 28 skeletogenesis-associated genes that potentially respond to estrogen signals and play role in craniofacial development. We foundE2mediated differential expression of genes involved in extracellular matrix (ECM) remodelling,mmp2/9/13,sparcandtimp2a, as well as components of skeletogenic pathways,bmp2a,erf,ptch1/2,rankl,rarabandsfrp1a. Furthermore, we identified a co-expressed network of genes, includingcpn1,dnajc3,esr1,lman1,rrbp1a,ssr1andtram1with a stronger inductive response to a lower dose ofE2during larval head development.
Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney
Authors: Lu Yuchao , Qin Baolong , Hu Henglong , Zhang Jiaqiao , Wang Yufeng , Wang Qing , Wang Shaogang
Published: March 2016

Background.MicroRNAs (miRNAs) influence a variety of biological functions by regulating gene expression post-transcriptionally. Aberrant miRNA expression has been associated with many human diseases. Urolithiasis is a common disease, and idiopathic hypercalciuria (IH) is an important risk factor for calcium urolithiasis. However, miRNA expression patterns and their biological functions in urolithiasis remain unknown.

Methods and Results.A multi-step approach combining microarray miRNA and mRNA expression profile and bioinformatics analysis was adopted to analyze dysregulated miRNAs and genes in genetic hypercalciuric stone-forming (GHS) rat kidneys, using normal Sprague-Dawley (SD) rats as controls. We identified 2418 mRNAs and 19 miRNAs as significantly differentially expressed, over 700 gene ontology (GO) terms and 83 KEGG pathways that were significantly enriched in GHS rats. In addition, we constructed an miRNA-gene network that suggested that rno-miR-674-5p, rno-miR-672-5p, rno-miR-138-5p and rno-miR-21-3p may play important roles in the regulatory network. Furthermore, signal-net analysis suggested that NF-kappa B likely plays a crucial role in hypercalciuria urolithiasis.

Conclusions.This study presents a global view of mRNA and miRNA expression in GHS rat kidneys, and suggests that miRNAs may be important in the regulation of hypercalciuria. The data provide valuable insights for future research, which should aim at validating the role of the genes featured here in the pathophysiology of hypercalciuria.
Silicon chemistry in the mesosphere and lower thermosphere
Authors: Plane John M. C. , Gómez‐Martín Juan Carlos , Feng Wuhu , Janches Diego
Published: March 2016

Silicon is one of the most abundant elements in cosmic dust, and meteoric ablation injects a significant amount of Si into the atmosphere above 80 km. In this study, a new model for silicon chemistry in the mesosphere/lower thermosphere is described, based on recent laboratory kinetic studies of Si, SiO, SiO2, and Si+. Electronic structure calculations and statistical rate theory are used to show that the likely fate of SiO2 is a two‐step hydration to silicic acid (Si(OH)4), which then polymerizes with metal oxides and hydroxides to form meteoric smoke particles. This chemistry is then incorporated into a whole atmosphere chemistry‐climate model. The vertical profiles of Si+ and the Si+/Fe+ ratio are shown to be in good agreement with rocket‐borne mass spectrometric measurements between 90 and 110 km. Si+ has consistently been observed to be the major meteoric ion around 110 km; this implies that the relative injection rate of Si from meteoric ablation, compared to metals such as Fe and Mg, is significantly larger than expected based on their relative chondritic abundances. Finally, the global abundances of SiO and Si(OH)4 show clear evidence of the seasonal meteoric input function, which is much less pronounced in the case of other meteoric species.
Statistical‐dynamical seasonal forecast of western North Pacific and East Asia landfalling tropical cyclones using the high‐resolution GFDL FLOR coupled model
Authors: Zhang Wei , Villarini Gabriele , Vecchi Gabriel A. , Murakami Hiroyuki , Gudgel Richard
Published: March 2016

This study examines the seasonal prediction of western North Pacific [WNP) and East Asia landfalling tropical cyclones (TCs) using the Geophysical Fluid Dynamics Laboratory(GFDL) Forecast‐oriented Low Ocean Resolution version of CM2.5 with Flux Adjustment (FLOR‐FA) and finite‐mixture‐model (FMM)‐based statistical cluster analysis. Using the FMM‐based cluster analysis, seven clusters are identified from the historical and FLOR‐FA‐predicted TC tracks for the period 1980–2013. FLOR‐FA has significant skill in predicting year‐to‐year variations in the frequency of TCs within clusters 1 (recurving TCs) and 5 (straight‐moving TCs). By building Poisson regression models for each cluster using key predictors (i.e., sea surface temperature, 500 hPa geopotential height, and zonal vertical wind shear), the predictive skill for almost all the clusters at all initialization months improves with respect to the dynamic prediction. The prediction of total WNP TC frequency made by combining hybrid predictions for each of the seven clusters in the hybrid model shows skill higher than what achieved using the TC frequency directly from FLOR‐FA initialized from March to July. However, the hybrid predictions for total WNP TC frequency initialized from January to February exhibit lower skill than FLOR‐FA. The prediction of TC landfall over East Asia made by combining the hybrid models of TC frequency in each cluster and its landfall rate over East Asia also outperforms FLOR‐FA for all initialization months January through July.
A membrane‐bound esterase PA2949 from Pseudomonas aeruginosa is expressed and purified from Escherichia coli
Authors: Kovacic Filip , Bleffert Florian , Caliskan Muttalip , Wilhelm Susanne , Granzin Joachim , Batra‐Safferling Renu , Jaeger Karl‐Erich
Published: March 2016

Pseudomonas aeruginosa strain 1001 produces an esterase (EstA) that can hydrolyse the racemic methyl ester of β‐acetylthioisobutyrate to produce the (D)‐enantiomer, which serves as a precursor of captopril, a drug used for treatment of hypertension. We show here that PA2949 from P. aeruginosa PA01, a homologue of EstA, can efficiently be expressed in an enzymatically active form in E. coli. The enzyme is membrane‐associated as demonstrated by cell fractionation studies. PA2949 was purified to homogeneity after solubilisation with the nonionic detergent, Triton X‐100, and was shown to possess a conserved esterase catalytic triad consisting of Ser137–His258–Asp286. Our results should allow the development of an expression and purification strategy to produce this biotechnologically relevant esterase in a pure form with a high yield.
Defending victimized peers: Opposing the bully, supporting the victim, or both?
Authors: Reijntjes Albert , Vermande Marjolijn , Olthof Tjeert , Goossens Frits A. , Aleva Liesbeth , van der Meulen Matty
Published: March 2016

To reduce bullying, more knowledge on children defending their victimized peers is critical. In previous work, predominantly cross‐sectional in nature, defending has typically been operationalized as one single, broad construct. However, there are good reasons to assume that attacking the bully (bully oriented defending) and comforting the victim (victim‐oriented defending) are relatively independent constructs, with potentially different correlates. This longitudinal study in the Netherlands (N = 394; Mage = 10.3) combined person‐ and variable‐centered techniques to examine relations between two different forms of defending and multiple outcome variables. In addition to the largest group scoring low on both types of defending, three subgroups emerged. A small group of “traditional,” predominantly female defenders, scored high on both forms of defending. These children were well liked and high in reputation‐based status, as indexed by perceived popularity and resource control. A larger, predominantly female second group only scored high on victim‐oriented defending. These children were also well liked, but low in reputation‐based status. The third group only scored high on bully oriented defending, and predominantly contained boys. These children were high in reputation‐based status but quite disliked, and they scored high on bullying. Findings strongly suggest that bully oriented defending does not in all cases reflect desirable interventions of empathic children. Aggr. Behav. 42:585–597, 2016. © 2016 Wiley Periodicals, Inc.
Broad‐Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells
Authors: Yang Chuan , Krishnamurthy Sangeetha , Liu Jie , Liu Shaoqiong , Lu Xiaohua , Coady Daniel J. , Cheng Wei , De Libero Gennaro , Singhal Amit , Hedrick James L. , Yang Yi Yan
Published: March 2016

In this study, a series of star‐shaped polycarbonates are synthesized by metal‐free organocatalytic ring‐opening polymerization of benzyl chloride (BnCl) and mannose‐functionalized cyclic carbonate monomers (MTC‐BnCl and MTC‐ipman) with heptakis‐(2,3‐di‐O‐acetyl)‐β‐cyclodextrin (DA‐β‐CD) as macroinitiator. The distributions and compositions of pendent benzyl chloride and protected mannose group (ipman) units are facilely modulated by varying the polymerization sequence and feed ratio of the monomers, allowing precise control over the molecular composition, and the resulting polymers have narrow molecular weight distribution. After deprotection of ipman groups and quaternization with various N,N‐dimethylalkylamines, these star polymers with optimized compositions of cationic and mannose groups in block and random forms exhibit strong bactericidal activity and low hemolysis. Furthermore, the optimal mannose‐functionalized polymer demonstrates mannose receptor‐mediated intracellular bactericidal activity against BCG mycobacteria without inducing cytotoxicity on mammalian cells at the effective dose. Taken together, the materials designed in this study have potential use as antimicrobial agents against diseases such as tuberculosis, which is caused by intracellular bacteria.
Efficient and Scalable Kinetic Resolution of Racemic 4‐Formyl[2.2]paracyclophane via Asymmetric Transfer Hydrogenation
Authors: Delcourt Marie‐Léonie , Turcaud Serge , Benedetti Erica , Micouin Laurent
Published: March 2016

Herein we wish to report a new non‐enzymatic kinetic resolution of racemic 4‐formyl[2.2]paracyclophane based on Noyori asymmetric transfer hydrogenations (KR‐ATH). Our approach, which provides an efficient access to enantiopure (Rp)‐ and (Sp)‐4‐formyl[2.2]paracyclophane (>99% ee, 39% and 41% isolated yields, respectively), is operationally simple and can be run on the gram‐scale thus confirming the practical applicability of this method.

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Copper‐Catalyzed or ‐Mediated CH Bond Functionalizations Assisted by Bidentate Directing Groups
Authors: Liu Jidan , Chen Guoshu , Tan Ze
Published: March 2016

Copper salts, which are abundant, relatively inexpensive and possess low toxicity, have long been used as versatile catalysts for various reactions in organic synthesis. Recently, the development of Cu‐catalyzed or ‐mediated CH functionalization reactions has gained significant attention. Since the pioneering work of Daugulis on the introduction of 8‐aminoquinoline and picolinic acid auxiliaries as removable directing groups in transition metal‐catalyzed CH bond activations, the combination of copper salts with these bidentate directing groups has emerged as an innovative strategy for the construction of carbon‐carbon or carbon‐heteroatom bonds through CH bond cleavage. In addition to the 8‐aminoquinoline and picolinamide systems, several other bidentate directing groups including the 2‐aminophenyloxazoline group by Yu and Dai and the PIP system by Shi, have been developed as well. This review intends to cover most of the recent advances on copper‐catalyzed or ‐mediated direct sp2 and sp3 CH bond functionalizations assisted by these bidentate directing groups. The major achievements in this area are discussed and catalogued by the type of bonds formed (CC, CO, CN, CS, CP etc.). Special attention is paid to the reaction mechanisms. Selected examples of substrates are listed as well. In addition, a personal outlook is given at the end.

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Exploration of Mechanisms behind Changes after Participation in a Parenting Intervention: A Qualitative Study in a Low‐Resource Setting
Authors: Mejia Anilena , Ulph Fiona , Calam Rachel
Published: March 2016

Parenting interventions are effective for preventing psychological difficulties in children. However, their active ingredients have not been comprehensively explored. How do they work? What are the mechanisms operating behind changes? In 2012, a randomized controlled trial of a parenting intervention was conducted in low‐resource communities of Panama. Effects on child behavioral difficulties, parental stress, and parenting practices were large in the short and long term. This was an ideal opportunity to explore potential mechanisms operating behind effects found in this low‐resource setting. Twenty‐five parents were interviewed. Data were analyzed through an inductive semantic thematic analysis. Three themes emerged from the data: (a) psychological mechanisms behind changes, (b) behavioral changes in parent, and (c) changes in the children. Parents described that the intervention triggered changes in emotion regulation, self‐efficacy, and problem solving. Parents also reported behavioral changes such as praising their children more often, who in turn seemed more responsible and better at following instructions. The study offers participant‐driven insight into potential pathways of change after participation in this parenting intervention, pathways that are often overlooked in quantitative studies. Future studies should further explore these pathways, through mediator and moderator analyses, and determine how much is shared across interventions and across different cultural settings.
1‐Naphthol Synthesis through Base‐Promoted SNAr Reactions of ortho‐Haloacetophenones Followed by Lewis‐Acid‐Catalyzed Cyclization
Authors: Yu Xiaoqiang , Zhu Peihong , Bao Ming , Yamamoto Yoshinori , Almansour Abdulrahman I. , Arumugam Natarajan , Kumar Raju Suresh
Published: March 2016

An efficient method was developed for the synthesis of 1‐naphthols through NaOtBu‐promoted SNAr reaction of ortho‐haloacetophenones followed by Lewis acid CuI‐catalyzed intramolecular condensation and isomerization. 1‐Naphthol derivatives were obtained in satisfactory yields from aryl bromide and aryl iodide substrates.
Oxidative Remote C−H Trifluoromethylation of Quinolineamides on the C5 Position with Iodobenzene Diacetate as the Oxidizing Agent
Authors: Wu Zhaoyang , He Yongqin , Ma Chaowei , Zhou Xiaoqiang , Liu Xingxing , Li Yamin , Hu Ting , Wen Ping , Huang Guosheng
Published: March 2016

A facile, metal‐free protocol has been developed for the remote trifluoromethylation of 8‐aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8‐aminoquinolineamides reacted with an inexpensive and commercially available CF3 source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.
Rekombinante Cyanobakterien für die asymmetrische Reduktion von C=C‐Bindungen mithilfe biokatalytischer Wasseroxidation
Authors: Köninger Katharina , Gómez Baraibar Álvaro , Mügge Carolin , Paul Caroline E. , Hollmann Frank , Nowaczyk Marc M. , Kourist Robert
Published: March 2016

Eine in Cyanobakterien exprimierte, rekombinante Enoat‐Reduktase wurde für die lichtkatalysierte, enantioselektive Reduktion von C=C‐Bindungen genutzt. Dabei ermöglicht die Kopplung von Oxidoreduktasen an die natürliche Photosynthese eine durch Wasseroxidation angetriebene asymmetrische Synthese. Durch den Verzicht auf zusätzliche Cosubstrate als Elektronendonoren wird die Bildung unerwünschter Nebenprodukte gemindert und die Atomökonomie der Reaktion erhöht. Die Verfügbarkeit von NADPH und die Menge an aktivem Enzym in der Zelle sind entscheidende Faktoren für die Produktbildung. Die Effizienz der Reaktion ist mit derjenigen typischer Ganzzell‐Biotransformationen in E. coli vergleichbar: Unter optimierten Bedingungen wurden 100 mg prochirales 2‐Methylmaleimid zu enantiomerenreinem 2‐Methylsuccinimid (99 % ee, 80 % Ausbeute an isoliertem Produkt) reduziert. Die hohen Produktausbeuten und die exzellente Enantiomerenreinheit durch den Einsatz rekombinanter Cyanobakterien in einer lichtgetriebenen Ganzzell‐Biotransformation ergeben einen einfachen und allgemein anwendbaren Syntheseansatz.
Stereoselective Formation of Fully Substituted Ketone Enolates
Authors: Haimov Elvira , Nairoukh Zackaria , Shterenberg Alexander , Berkovitz Tiran , Jamison Timothy F. , Marek Ilan
Published: March 2016

The application of stereochemically defined acyclic fully substituted enolates of ketones to the enantioselective synthesis of quaternary carbon stereocenters would be highly valuable. Herein, we describe an approach leading to the formation of several new stereogenic centers through a combined metalation–addition of a carbonyl–carbamoyl transfer to reveal in situ stereodefined α,α‐disubstituted enolates of ketone as a single stereoisomer. This approach could produce a series of aldol and Mannich products from enol carbamate with excellent diastereomeric ratios.
Functional characterization of CYP52G3 from Aspergillus oryzae and its application for bioconversion and synthesis of hydroxyl flavanone and steroids
Authors: Uno Tomohide , Yanase Takeshi , Imaishi Hiromasa
Published: March 2016

Aspergillus oryzae is a fungus widely used in traditional Japanese fermentation industries. Cytochrome P450 (CYP) proteins are ubiquitously distributed in nature and display a broad range of enzymatic activities. A novel CYP52 (CYP52G3) gene was found in A. oryzae. In this study, we report the functional characterization of CYP52G3. The recombinant protein was expressed heterologously in Escherichia coli, and its membrane fraction isolated. CYP52G3 showed activities for 7‐ethoxycoumarin and α‐naphtoflavone. Furthermore, CYP52G3 hydroxylated flavanone at the 4′ and 6 position and metabolized some hydroxyl‐flavanones and steroids. Bioconversion experiments indicated that CYP52G3 could convert flavanone and testosterone in a synthetic medium. The conversion rates of flavanone and testosterone at 24 H were 50% and 70%, respectively. These results support that CYP52G3 could prove a useful enzyme for the efficient production of new compounds from flavonoids and steroids.
Reliability and reproducibility of individual differences in functional connectivity acquired during task and resting state
Authors: Shah Lubdha M. , Cramer Justin A. , Ferguson Michael A. , Birn Rasmus M. , Anderson Jeffrey S.
Published: March 2016

Objectives

Application of fMRI connectivity metrics as diagnostic biomarkers at the individual level will require reliability, sensitivity and specificity to longitudinal changes in development, aging, neurocognitive, and behavioral performance and pathologies. Such metrics have not been well characterized for recent advances in BOLD acquisition.

Experimental Design

Analysis of multiband BOLD data from the HCP 500 Subjects Release was performed with FIX ICA and with WM, CSF and motion parameter regression. Analysis with ROIs covering the gray matter at 5 mm resolution was performed to assess functional connectivity. ROIs in key areas were used to demonstrate statistical differences between specific connections. Reproducibility of group‐mean functional connectivity and for single connections for individuals was evaluated for both resting state and task acquisitions.

Principal Observations

Systematic differences in group‐mean connectivity were demonstrated during task and rest and during different tasks, although individual differences in connectivity were maintained. Reproducibility of a single connection for a subject and across subjects for resting and task acquisition was demonstrated to be a linear function of the square root of imaging time. Randomly removing up to 50% of time points had little effect on reliability, while truncating an acquisition was associated with decreased reliability. Reliability was highest within the cortex, and lowest for deep gray nuclei, gray‐white junction, and near large sulci.

Conclusions

This study found systematic differences in group‐mean connectivity acquired during task and rest acquitisions and preserved individual differences in connectivity due to intrinsic differences in an individual's brain activity and structural brain architecture. We also show that longer scan times are needed to acquire data on single subjects for information on connections between specific ROIs. Longer scans may be facilitated by acquisition during task paradigms, which will systematically affect functional connectivity but may preserve individual differences in connectivity on top of task modulations.
Understanding Protein–Protein Interactions: Essential Players in (Patho)physiology (Part 1)
Authors: Wilson Andrew J. , Gunning Patrick T.
Published: March 2016

This is the first of a two‐part Editorial by the Guest Editors of the ChemBioChem and ChemMedChem joint Special Issue on Protein–Protein Interactions. Part 2 can be accessed via http://dx.doi.org/10.1002/cmdc.201600158; the complete issue can be viewed here: bit.ly/cbcVIppi.
Plaque morphology predictors of side branch occlusion after provisional stenting in coronary bifurcation lesion: Results of optical coherence tomography bifurcation study (ORBID)
Authors: Kini Annapoorna S. , Vengrenyuk Yuliya , Pena Jacobo , Yoshimura Takahiro , Panwar Sadik R. , Motoyama Sadako , Kezbor Safwan , Hasan Choudhury M. , Palkhiwala Sameet , Kovacic Jason C. , Moreno Pedro , Baber Usman , Mehran Roxana , Narula Jagat , Sharma Samin K.
Published: March 2016

Objectives

The aim of this study was to identify the predictors of side branch (SB) ostial stenosis developed after provisional stenting of the main vessel (MV) using optical coherence tomography (OCT).

Background

Provisional stenting remains the main approach to treatment of bifurcation lesions; however, it may result in the narrowing of SB ostium. There is little information about underlying plaque morphology of the MV lesion and its potential impact on the SB after provisional stenting.

Methods

Patients with stable coronary disease with angiographic MV lesion not involving SB were included in a prospective single center study. The primary outcome was significant SB ostium stenosis (SBOS), defined as residual stenosis of >50% after MV stenting.

Results

Thirty bifurcation lesions in 30 patients were analyzed in the study. Poststenting significant SBOS was observed in 30% of patients. The MV lesions with SBOS > 50% were characterized by a higher prevalence of lipid rich plaques (100 vs. 64%, p = 0.040) and spotty calcifications (60 vs. 0%, p = 0.005). Maximal lipid arcs were greater (257° vs. 132°, p = 0.001) and lipid volume index was higher (1380 vs. 574, p = 0.012) in the SBOS >50% group. Multivariate logistic regression analysis identified maximal lipid arc (odds ratio (OR): 1.014, p = 0.038) and the presence of lipid plaque contralateral to SB ostium (OR: 8.14, p = 0.046) before stenting as independent predictors of significant SBOS after PCI.

Conclusions

High lipid content of the MV lesion and a contralateral location of lipid in the bifurcation area may contribute to SBOS after provisional stenting. © 2016 Wiley Periodicals, Inc.
Ullmann Coupling Reaction of Nitro‐Substituted Aryl Halides with Phenols under Mild Conditions: Micro‐/Mesoporous Hierarchical LaAlPO‐5 Zeolite Catalyst
Authors: Ke Qingping , Wu Mingzhou , Wang Chao , Lu Guanzhong
Published: March 2016

Heterogeneous catalytic reactions of aromatic organic molecules over zeolite catalysts present many challenges because of the shape selectivity of the micropores of conventional zeolites that limits the diffusion of aromatic molecules. Herein, Ullmann coupling reactions of phenols with nitro‐substituted aryl halides were catalyzed by rare‐earth‐doped mesoporous AlPO‐5 zeolites in the absence of ligands. The AlPO‐5‐MAlPO‐5‐M zeolites had a pure AFI structure and consisted of spherical particles assembled by nanofibers. The rare‐earth elements were highly dispersed in the AlPO‐5‐MAlPO‐5‐M samples. The LaAlPO‐5‐MAlPO‐5‐M zeolite is an excellent catalyst for Ullmann coupling reactions of phenols and nitro‐substituted aryl halides. Mesoporous LaAlPO‐5 has an excellent stability and recyclability in the Ullmann coupling of p‐X‐nitrobenzene (X=Cl, Br, and I) with 2‐naphthol. These results are important in the exploration of attractive Ullmann coupling reactions and in the development of mesoporous zeolite catalysts for other organic reactions.
ChemInform Abstract: ANALYSIS OF THE ELUTION CURVE IN ELUTING LUTETIUM FROM CATION‐EXCHANGER WITH α‐HYDROXYISOBUTYRIC ACID
Authors: KUBOTA MASUMITSU
Published: March 2016

Das Verhalten von Lu bei der Elution von einer Kationenaustauschersäule mit einer sauren α‐Hydroxybuttersäurelösung (pH 3,7) wird als Funktion des Verteilungsverhältnisses von Lu in der Säule (Harz/ Lösung), der Fließgeschwindigkeit, der Temperatur und der Lu‐Menge analysiert.
ChemInform Abstract: COMPLEX CATION‐RADICAL SALTS DERIVED FROM PHENOTHIAZINE AND RELATED COMPOUNDS
Authors: DOI SUSUMU , MATSUNAGA YOSHIO
Published: March 2016

Es wird der spezifische elektrische Widerstand z.B. eines Gemisches aus Phenothi‐i azin und seines Kationradikalbromids untersucht.
ChemInform Abstract: PHOTOCHROMIC 1,3‐BENZOXATHIOLSPIROPYRANS. SYNTHESIS AND KINETIC STUDY OF THE THERMAL DECOLORATION
Authors: APPRIOU PIERRE , GARNIER FRANCIS , GUGLIELMETTI ROBERT
Published: March 2016

In Gegenwart von Perchlorsäure kondensieren sich das Chinon (I) mit dem Amid (II) und den Salicylaldehyden (III) zu den Styrylderivaten (IV), die in basischem Medium zu den Spiropyranen (Va) cyclisiert werden.
ChemInform Abstract: MICHAEL REACTIONS OF α‐PHENYLTHIO AND α‐PHENYLSULFINYL CROTONIC ESTERS WITH CYCLIC ENONES
Authors: HAGIWARA HISAHIRO , NAKAYAMA KIYOSHI , UDA HISASHI
Published: March 2016

Die Michael‐Reaktion des Crotonsäureesters (I) mit den Cyclohexenonen (II) in Gegenwart von Hexamethylphosphorsäuretriamid (HMPT) ergibt die Bicyclooctanone (III).
ChemInform Abstract: SELECTIVE CATALYTIC REDUCTION OF SUBSTITUTED ANILINES TO SUBSTITUTED CYCLOHEXYLAMINES AND OF BENZENE‐ AND PHENYLALKANESULFONIC ACIDS TO CYCLOHEXANE‐ AND CYCLOHEXYLALKANESULFONIC ACIDS
Authors: EGLI ROBERT , EUGSTER CONRAD HANS
Published: March 2016

Bei Verwendung von Rh‐Alox‐Katalysatoren lassen sich die Äther (I) unter bestimmten Bedingungen ohne starke Hydrogenolyse zu den Aminocyclohexyläthern (II) (cis‐trans‐Gemische mit überwiegend cis‐Isomeren) reduzieren.
ChemInform Abstract: FORMATIONS AND REACTIONS OF O‐BENZOQUINONE MONO‐ AND DIIMINES. I
Authors: NOGAMI TAKASHI , HISHIDA TADANORI , YAMADA MASAKAZU , MIKAWA HIROSHI , SHIROTA YASUHIKO
Published: March 2016

Die Bildung der beiden Titelverbindungen durch Oxidatio:n von o‐Aminophenol bzw. o‐Phenylendiamin mit PbOg in Äther oder mit Hexacyanoferrat(III) in wässriger Lösung wird spektroskopisch untersucht, und die Hydrolyseempfindlichkeit der Verbindungen im pH‐Bereich 4,5‐12 wird ermittelt.
ChemInform Abstract: REACTIONS OF NITRENES WITH STRAINED OLEFINS. PREPARATION OF DIMETHYL‐N‐PHTHALIMIDYL‐5‐AZABICYCLO(2.1.0)PENTANE‐1,4‐DICARBOXYLATE
Authors: MEYER G. R. , STAVINOHA J. JUN.
Published: March 2016

Der Cyclobutendicarbonsäureester (I) und N‐Amino‐phthalimid (II) reagieren in Methylenchlorid in Gegenwart von B1eitetraacetat zu dem Aziridinderivat (III).
ChemInform Abstract: SYNTHESES OF 2,3‐DIALKOXY‐2,3‐DIHYDROBENZO(B)FURANS
Authors: SROGI J. , JANDA M. , STIBOR I. , ROZINEK R.
Published: March 2016

Die Elektrolyse von Benzofuranen (I) in Alkohol (II) bei ‐10°C in Gegenwart eines Elektrolyten führt zu 2,3‐Dia1koxy‐2,3‐dihydrobenzofuranen (III).
ChemInform Abstract: REACTIONS OF 3‐ETHOXY‐1,2‐DITHIOLIUM SALTS WITH BASES
Authors: FAUST JUERGEN
Published: March 2016

Der spezifische Verlauf der Reaktion der Titelverbindungen mit prim. Aminen wird durch den Substituenten in 5‐Stellung bestimmt.
ChemInform Abstract: 1,2,3‐BENZOTRIAZIN‐4‐ONES AND RELATED SYSTEMS. IV. THERMAL DECOMPOSITION OF 3‐IMIDOYLATED 1,2,3‐BENZOTRIAZIN‐4‐ONES. NEW SYNTHESIS OF 1,2‐DIARYL‐1,4‐DIHYDROQUINAZOLIN‐4‐ONES
Authors: PATERSON T. MCC. , SMALLEY R. K. , SUSCHITZKY H.
Published: March 2016

1,2,3‐Benzotriazin‐4‐on (I) wird mit Natriumhydrid in Dimethylformamid metalliert und mit Imidchloriden (II) zu (III) umgesetzt, deren Pyrolyse in Paraffinöl bei 300°C zu 1,2‐Diaryl‐1,4‐dihydrochinazolin‐4‐onen (IV) führt.
ChemInform Abstract: PHOTOACTION IN THE COURSE OF CHELATE FORMATION. I. LIGAND PHOTOACTIVITY IN THE BORIC ACID‐BENZOYLACETONE 1 1 INTERACTION
Authors: MARCANTONATOS M.
Published: March 2016

Die Bildung des Borobenzoylacetonid‐ Chelats (I) aus photoaktiviertem Benzoylaceton und Borsäure in konz. Schwefelsäure/Äther‐Lösung wird kinetisch untersucht.
ChemInform Abstract: CHROMIUM(II) COMPLEXES WITH PYRAZOLES AND IMIDAZOLES AS LIGANDS
Authors: MANI F. , SCAPACCI G.
Published: March 2016

Die Cr(II)‐ Komplexe (I)‐(III) werden durch Umsetzung von Cr(II)‐halogeniden mit den Liganden dargestellt.
ChemInform Abstract: ORGANOCOBALT CLUSTER COMPLEXES. XVIII. FRIEDEL‐CRAFTS ACYLATION OF DIARYLACETYLENEDICOBALT HEXACARBONYL COMPLEXES. DICOBALT HEXACARBONYL UNIT AS A PROTECTING GROUP FOR THE ACETYLENE FUNCTION
Authors: SEYFERTH DIETMAR , NESTLE MARA OZOLINS , WEHMAN ANTHONY T.
Published: March 2016

Die Friedel‐Crafts Acetylierung der Acetylenkomplexe (I) erfolgt rasch und in guten Ausbeuten je nach Bedingungen und eingesetztem Molverhältnis zu den mono‐ und/oder diacetylierten Produkten (II) und (III).
ChemInform Abstract: STUDIES ON INTERACTION OF ISOCYANIDE WITH TRANSITION METAL COMPLEXES. XIII. PREPARATION OF CARBENE COMPLEXES OF NICKEL, IRON, AND COBALT THROUGH PROTONATION OF MONOIMINO AND POLYIMINO TYPE COMPLEXES
Authors: YAMAMOTO YASUHIRO , YAMAZAKI HIROSHI
Published: March 2016

Die Reaktion der Ni‐ und Fe‐Komplexe (I) des Iminotyps mit Tetrafluoroborsäure führt zu den kationischen Carben‐ Komplexen (II).
ChemInform Abstract: (2,2‐DIMETHYL‐2H‐BENZIMIDAZOLE)COPPER(I) PERCHLORATE COMPLEXES
Authors: JEHN WERNER , RADEGLIA REINER
Published: March 2016

Die Umsetzung des o‐Phenylendiamin‐Cu(II)‐Komplexes (I) mit Aceton führt zu dem Dimethyl‐2H‐benzirnidazol‐Cu(I)‐perchlorat‐Komplex (II), der zwei Mol Acetooder Benzonitril unter Bildung tieffarbiger Verbindungen addiert.
ChemInform Abstract: SYNTHESIS OF SUGAR DERIVATIVES OF N‐ALKYL‐N‐NITROSOUREA
Authors: MACHINAMI TOMOYA , KOBAYASHI KAZUKI , HAYAKAWA YOSHIKI , SUAMI TETSUO
Published: March 2016

Aus den Glucosaminiden (I) werden durch Behandlung mit NaNOg in wäßriger Essigsäure die Nitrosoharnstoffe (II) erhalten.
ChemInform Abstract: ELECTRONIC STRUCTURE OF HIGHLY SYMMETRIC COMPLEXES OF LANTHANOIDS AND ACTINOIDS. II. ELECTRONIC RAMAN SPECTRA AND CRYSTAL FIELD SPLITTING PATTERNS OF DICESIUM SODIUM PRASEODYMIUM(III) CHLORIDE
Authors: AMBERGER H.‐D. , FISCHER R. D. , ROSENBAUER G. G.
Published: March 2016

Die Ramanspektren grobkristalliner Proben der Verbindung CS2 NaPr(III)Cl6 weisen bei ca. 10 Keine Reihe von rein "elektronischen " Banden a auf, die sowohl aufgrund ihrer Anzahl als auch ihrer relativen Gruppierung auf eine schwache Verzerrung der bislang als streng oktaedrisch betrachteten PrClä ′‐Einheiten hinweisen.
ChemInform Abstract: REARRANGEMENTS IN THE PHOTOCHEMICAL SYNTHESIS OF INDOLIC COMPOUNDS
Authors: RICHE C. , CHIARONI A.
Published: March 2016

Die Belichtung des heterocyclischen Nitrils (I) ergibt das Cyclisierungsprodukt (II).
ChemInform Abstract: CHELETROPIC ADDITIONS OF DIFLUORO‐ AND DICHLOROCARBENES TO HINDERED NORBORNADIENES
Authors: JEFFORD C. W. , GRAHAM W. D. , BURGER U.
Published: March 2016

Aus Phenyltrifluormethylquecksilber und dem Norbornadien (I) erhält man in Gegenwart von Natriumjodid bei 80°C in Benzol das Carben‐Addukt (II).
ChemInform Abstract: NOVEL METHOD FOR SYNTHESIS OF UNSYMMETRICAL SULFIDES FROM ALCOHOLS AND THIOLS BY UTILIZING AMINOPHOSPHONIUM SALTS
Authors: TANIGAWA Y. , KANAMARU H. , MURAHASHI S.‐I.
Published: March 2016

Die Zimtalkohole (IIa) und (IIb) werden mit Natriumhydrid in Dimethylformamid in die Natriumalkoholate umgewandelt und letztere bei Raumtemperatur in Gegenwart des Phosphoniumsalzes (I) mit Äthanthiol zu den Thioäthern (IVa) und (IVb) umgesetzt.
ChemInform Abstract: 1,2‐CYCLOPROPA‐4,5‐CYCLOBUTABENZENE, A NOVEL STRAINED BENZENE DERIVATIVE
Authors: SAWARD C. J. , VOLLHARDT K. P. C.
Published: March 2016

Aus dem Hexadiin (I) und dem Silylacetylen (II) erhält man das Benzocyclobutenderivat (III), das durch Bromierung und anschließende Behandlung mit n‐Butylli = thium in Tetrahydrofuran in das Cyclopropacyclobutabenzol (IV) umgewandelt wird.
ChemInform Abstract: THE REACTION OF 2,4‐DIOXO‐3‐AZABICYCLO(3.3.1)NONANE WITH ORGANOMETALLIC REAGENTS, 2. CYCLIZATION AND REDUCTION OF 3‐(DIPHENYLHYDROXYMETHYL)CYCLOHEXANECARBOXYLIC ACID N‐METHYLAMIDE
Authors: SCHILL D. , SCHNEIDER W.
Published: March 2016

Das durch Grignardierung von (I) über (II) erhältliche Hydroxyamid (III) liefert beim Erhitzen mit einer 20 %igen Polyphosphorsäure in Trifluoressigsäure über den Iminoäther (IV) das Lacton (V).
ChemInform Abstract: INTERMOLECULAR HYDRIDE TRANSFER REACTIONS. V. ACID‐INDUCED REDOX REACTION OF 4‐PHENYLFLAV‐3‐ENE
Authors: OESTENSEN EILIF TERJE , MISHRIKEY MORCOS MICHAEL
Published: March 2016

Das Flaven (I) unterliegt in Gegenwart von Perchlorsäure oder Trifluoressigsäure der Disproportionierung.
ChemInform Abstract: SYNTHESIS OF 1,3,4,9‐TETRAHYDRO‐1‐ALKYLTHIOPYRANO(3,4‐B)INDOLE‐1‐ACETIC ACIDS. SULFUR ISOSTER OF PRODOLIC ACID
Authors: JIRKOVSKY I. , HUMBER L. G. , NOURELDIN R.
Published: March 2016

Durch Kondensation von Thiotryptophol (I) mit β‐Ketoestern und anschließende Hydrolyse erhält man die gesuchten Verbindungen (II), von denen eine zu (III) methyliert wird.
ChemInform Abstract: SYNTHESIS OF MACROCYCLIC COMPOUNDS. 19. MACROCYCLIC BIS(β‐OXO ESTERS) INCLUDING THIOPHENE RINGS AND SELECTION OF OPTIMUM CONDITIONS FOR THEIR PREPARATION
Authors: TAITS S. Z. , KRASNYANSKAYA E. A. , GOL'DFARB YA. L. , KONONOV N. F. , POGORELOV A. G. , MERZHANOVA R. F.
Published: March 2016

Die 2‐w‐Jodalkyl‐5‐(carbäthoxy‐acetyl)‐thiophene (I) lassen sich mit Kaliumcarbonat zum cyclischen Diester (IIa) bzw. den Verbindungen (IIb)‐(IVb) cyclisieren.
ChemInform Abstract: LANTHANIDE COMPLEXES WITH BIS(2′‐QUINOLYL)‐2,6‐PYRIDINE
Authors: GURRIERI S. , MUSUMECI S. , RIZZARELLI E. , SEMINARA A.
Published: March 2016

Die Komplexsalze (I) bis (IV) werden durch östündiges Rückflußkochen entsprechender Seltenerdmetallsalze in Äthanol/Orthoameisensäure und anschließenden Zusatz des Liganden in Benzol dargestellt.
ChemInform Abstract: MONODENTATE AMINO ACID ESTER AND PEPTIDE ESTER COMPLEXES OF COBALT(III)
Authors: HALL T. L. , LAURIE S. H.
Published: March 2016

Durch Reaktion des Na‐salzes von (I) mit wässrigen Lösungen der Esterhydrochloride werden die Komplexe (II) dargestellt.
ChemInform Abstract: CHEMISTRY OF METAL CARBONYLS. LXXIII. TRICARBONYLIRON AND ‐RUTHENIUM COMPLEXES OF BICYCLO(4.2.0)OCTA‐2,4,7‐TRIENES
Authors: COOKE MICHAEL , HOWARD JUDITH A. K. , RUSS CHARLES R. , STONE F. GORDON A. , WOODWARD PETER
Published: March 2016

Die Thermolyse der bekannten kristallinen Verbindungen (I) führt unter Isomerisierung zu den entsprechenden Komplexen (II) des Bicycloliganden, wobei die Gegenwart der koordinierten Metalltricarbonylgruppe und der sperrige Substituent am Cyclooctatetraenring in (I) begünstigend auf die Isomerisation wirken.
ChemInform Abstract: SECOANDROSTANE CARBOXYLIC ACIDS AS ENANTIOMERIC PROSTAGLANDIN ANALOGS. II. 6‐PENTYL‐4‐NOR‐3,5‐SECOANDROSTANE‐3‐CARBOXYLIC ACID
Authors: BAUMGARTH M. , IRMSCHER K.
Published: March 2016

Ausgehend vom bekannten Epoxyandrostanderivat (I) werden zunächst über die Zwischenstufe (II) die epimeren 6‐Desoxyverbindungen (IIIa) bzw. (IIIb) dargestellt.
ChemInform Abstract: ELECTROCHEMICAL STUDIES IN FUSED ETHYLAMMONIUM CHLORIDE (EAC). IV. CHRONOPOTENTIOMETRIC INVESTIGATIONS OF LEAD(II) CHLORIDE IN FUSED EAC
Authors: TWARDOCH URSZULA , KISZA ADOLF
Published: March 2016

In der untersuchten Salzschmelze tritt als Parallelreaktion zur anodischen Auflösung geringfügige chemische Auflösung des Pb auf.
ChemInform Abstract: HIGH TEMPERATURE REACTION OF IRON IN SULPHUR DIOXIDE
Authors: CHATTERJEE B. , DOWELL A. J.
Published: March 2016

Die Reaktion von reinem F e in trocknem SO2 wird im Temperaturbereich von 500‐885°C untersucht.
ChemInform Abstract: THERMAL DECOMPOSITION OF AMMONIUM METAVANADATE
Authors: KHULBE K. C. , MANN R. S.
Published: March 2016

Die Produkte der thermischen Zersetzung von NH4‐metavanadat werden bei verschiedenen Temperaturen zwischen 100 und 700°C durch Röntgenbeugung, IR‐ und ESR‐Spektren untersucht.
ChemInform Abstract: THE 1,4‐CYCLOADDITION REACTION OF ENAMINODITHIOCARBOXYLATE DERIVATIVES WITH DIMETHYL ACETYLENEDICARBOXYLATE
Authors: KOBAYASHI G. , MATSUDA Y. , TOMINAGA Y. , MIZUYAMA K.
Published: March 2016

Die Umsetzung einer Reihe von Enamino‐dithiocarbonsäuremethylestern mit Acetylendicarbonsäuremethylester (II) als Dienophil führt zu Spiroverbindungen.
ChemInform Abstract: THE 1,3‐DIPOLAR CHARACTER OF SIX‐MEMBERED AROMATIC RINGS. XIV. DOUBLE CYCLOADDITION TO 3‐OXIDO‐1‐PHENACYLPYRIDINIUM
Authors: DENNIS N. , KATRITZKY A. R. , PARTON S. K.
Published: March 2016

Das aus Hydroxypy?din (I) und Phenacylbromid (II) entstehende Pyridiniumbromid (III) reagiert in Acetonitril in Gegenwart von Triäthylamin über das Betain (IV) mit Acrylnitril (V) zu einem Diaddukt (VI).
ChemInform Abstract: REACTION MECHANISM OF ESTER FORMATION FROM N‐HYDROXYSUCCINIMIDE AND ACYLAMINO ACIDS USING DICYCLOHEXYLCARBODIIMIDE
Authors: MORIMOTO H. , KAWAKAMI T. , HAYASHI N.
Published: March 2016

Die Umsetzung von lgO‐markierter Aminosäure mit N‐Hydroxysuccinimid (II) in Gegenwart von Dicyclohexylcarbodiimid (DCC) in Dioxan oder Dimethoxyäthan bei 0°C führt zu markiertem Dicyclohexylharnstoff (IV), so daß bewiesen ist, daß die Aminosäure durch Abspaltung des Hydroxyls der Carboxylgruppe mit DCC.aktiviert wird und dann mit N‐Hydroxysuccinimid den Aktivester bildet.
ChemInform Abstract: ORGANIC SYNTHESIS USING ENZYMES IN TWO‐PHASE AQUEOUS TERNARY POLYMER SYSTEMS
Authors: POLLAK ALFRED , WHITESIDES GEORGE M.
Published: March 2016

Es wird z.B. die Umwandlung von Glucose‐6‐phosphat in 6‐Phospho‐gluconat mit Ficoll‐UCON 50 HB als 2‐Phasen‐System durch die entsprechende Dehydrogenase untersucht.
ChemInform Abstract: CHEMISTRY OF CARBONYL CYANIDE. XVI. REACTION OF CARBONYL CYANIDE WITH KETONES
Authors: KOCIOLEK KAROL , LEPLAWY MIROSLAW
Published: March 2016

Die Umsetzung von Carbonylcyanid (I) mit den Ketonen (II) liefert die Cyanformiate (III), von denen (IIIa), (IIId) und (IIIe) kristallin erhalten werden können (Diskussion des Reaktionsmechanismus).
ChemInform Abstract: SYNTHESIS OF SOME DI‐ AND OLIGOPEROXIDE COMPOUNDS BASED ON 2,5‐DIMETHYLHEXANE‐2,5‐BISHYDROPEROXIDE
Authors: BYLINA G. S. , UVAROVA L. R.
Published: March 2016

Durch Reaktionen des Bishydroperoxids (I) mit den Dicarbonsäureanhydriden (II) in Tetrahydrofuran bei 50°C und Chlorierungen der entstehenden stabilen sauren Perester (III) mit Oxalylchlorid bei 50°C werden die Peresterchloiide (IV) dargestellt.
ChemInform Abstract: SILANE REDUCTIONS IN ACIDIC MEDIA. VI. MECHANISM OF ORGANOSILANE REDUCTIONS OF CARBONYL COMPOUNDS. TRANSITION STATE GEOMETRIES OF HYDRIDE TRANSFER REACTIONS
Authors: DOYLE P. M. , WEST C. T.
Published: March 2016

Silane Reductions in Acidic Media.
ChemInform Abstract: DITERTIARY DIAMINE COMPOUNDS
Authors: SCHNEKENBURGER J.
Published: March 2016

Die auf verschiedenen Wegen erfolgende Synthese der ditertiären aliphatischen Diaminoverbindungen (I) wird beschrieben.
ChemInform Abstract: USE OF PHASE TRANSFER CATALYSIS. II. DIARYLOXYMETHANES AND FORMALDEHYDE ACETALS
Authors: DEHMLOW E. V. , SCHMIDT J.
Published: March 2016

Die Phenole (I) reagieren mit Methylenchlorid (II) bei Raumtemperatur in Gegenwart von festem gepulvertem Kaliumhydroxid und Tricapryl‐methylammoniumchlorid als Phasentransfer‐Katalysator zu den Dia1yloxymethanen (III).
ChemInform Abstract: SYNTHESIS OF ARYLACETONES BY THE SRN 1 ARYLATION OF ACETONE ENOLATE ION
Authors: BUNNETT J. F. , SUNDBERG J. E.
Published: March 2016

Arylbromide und ‐jodide (I), selbst sterisch stark gehinderte, reagieren in flüssigem Ammoniak bei UV‐Bestrahlung mit Acetonenolat (II) zu Arylacetonen (III), wobei als Nebenprodukte die Diarylacetone (IV) gebildet werden.
ChemInform Abstract: CATALYTIC OXIDATION OF 2,6‐DI‐T‐BUTYLPHENOL BY SALCOMINE‐TYPE COMPLEXES IN THE PRESENCE OF WATER
Authors: FULLERTON T. J. , AHERN S. P.
Published: March 2016

In Gegenwart von 4‐Hydroxysalcomin (I) wird 2,6‐Di‐tert.‐ butyl‐phenol (II) durch Sauerstoff in einem 9: 1‐Gemisch aus Methanol und Wasser zu dem Benzochinon (III) und dem Diphenochinon (IV) oxidiert, wobei durch Zusatz von Natriumcarbonat oder Natriumhydroxid die Reaktionsgeschwindigkeit erhöht wird.
ChemInform Abstract: N‐ARYLSULFONYL α‐HALODIMETHYL IMINOSULFOXIDES
Authors: MARKOVSKII L. N. , VASIL'EV V. V. , SINITSA A. D. , NUZHDINA YU. A.
Published: March 2016

Die N‐Chlor‐arensulfonsäureamid‐ N‐Na‐Salze (I) lassen sich mit den α‐Halogendimethylsulfoxiden (II) in Tetrahydrofuran exotherm zu den Titelverbindungen (III) umsetzen.
ChemInform Abstract: BEHAVIOR OF ARENESULFONYL‐ AND ARENESULFINYL AMIDES TOWARDS APROTIC DIAZOTIZATION
Authors: DE LUCA G. , RENZI G. , BARTOCCI V. , PANATTONI C.
Published: March 2016

Durch Diazotierung von p‐Toluolsulfinamid (I) mit Isopentylnitrit (II) in Benzol bei 74°C entsteht unter Stickstoffentwicklung ein Gemisch aus p‐Toluolsulfinsäure (III) (48 % Ausbeute), Isopentyl‐p‐toluolsulfinat (IV) (12 % Ausbeute), Phenyl‐p‐tolylsulfoxid (V) (7 % Ausbeute) und unverändertem Sulfinamid (I).
ChemInform Abstract: BENZOSPIRANS BEARING BASIC SUBSTITUTION. II. AMINES DERIVED FROM 3′,4′‐DIHYDROSPIRO(CYCLOHEXANE‐1,2′(1′H)‐NAPHTHALEN)‐4‐ONE AND 3′,4′‐DIHYDRO(CYCLOHEXANE‐1,1′(2′H)‐NAPHTHALEN)‐4‐ONE
Authors: LEDNICER D. , EMMERT D. E.
Published: March 2016

Aus dem bekannten Ester (Ia) erhält man über eine Homologisierung über (Ib)‐(Id) die Carbonsäure (Ie), die nach Hydrolyse zu (II) das spirocyclische Diketon (III) gibt, dessen Monoketal (IV) zu (V) reduziert werden kann.
ChemInform Abstract: ASYMMETRIC SYNTHESIS OF OXAZIRIDINES
Authors: BELZECKI C. , MOSTOWICS D.
Published: March 2016

Carbonylverbindunge:n (I) werden in die optisch aktiven Schiffschen Basen (III) übergeführt und diese mit m‐Chlorperbenzoesäure zu den Oxaziridinen (IV) bzw. (V) oxidiert, wobei die einzelnen Diastereomeren in stark unterschiedlichen Anteilen gebildet werden.
ChemInform Abstract: THE 1,3‐DIPOLAR CYCLOADDITIONS. LXXVI. CYCLOADDITIONS OF DIAZOMETHANE TO SUBSTITUTED BUTADIENES
Authors: HUISGEN R. , OHTA A. , GEITTNER J.
Published: March 2016

Die 1‐substituierten Butadiene (I) reagieren mit Diazomethan (II) zu 3‐Vinylpyrazolinderivaten (III), die leicht bei Raumtemperatur, beim Erhitzen oder (h durch Säurekatalyse in die 2‐Pyrazoline (IV) übergehen, die als l‐Nitroso‐ und 1‐Carbamoyl‐Derivate 0V) und (VI) charakterisiert werden.
ChemInform Abstract: SYNTHESIS, CONFIGURATION, AND CONFORMATION OF STEREOISOMERIC 2‐METHYL‐5‐CHLORO‐2,6‐DISUBSTITUTED TETRAHYDROPYRANS. PMR DATA
Authors: SAMITOV YU. YU. , ALEKSANDROVA I. A. , KHAIRULLIN V. K.
Published: March 2016

Das aus dem Dihydropyran (I) unter der Einwirkung von N‐Chlor‐succinimid (NCS) in Wasser‐Diäthyläther bei 15‐20°C entstehende Chlorhydrin (II) wird durch Acylierung mit Acetanhydrid in Pyridin bei 10°C in das Acetoxychlortetrahydropyran (III) übergeführt.
ChemInform Abstract: HETEROAROMATIC CHAINS AND THEIR CYCLIZATION PRODUCTS. III. DIELS‐ALDER REACTIONS BETWEEN THIOAMIDE VINYLOGS AND OPEN‐CHAIN AND CYCLIC ACRYLIC DIENOPHILES. CHEMICAL PROPERTIES OF 2‐ AND 3‐SUBSTITUTED 2H‐THIOPYRANS
Authors: PRADERE J. P. , N'GUESSAN Y. T. , QUINIOU H. , TONNARD F.
Published: March 2016

Die Reaktion des vinylogen Thioamids (I) mit den Acrylsäure‐Derivaten (II) verläuft unter Cycloaddition oder Cyclisierung‐Eliminierung zu den Dihydrothiopyranen (III) oder den Thiopyranen (IV); (IVa) wird auch durch Erhitzen von (IIIa) oder (IIIb) mit l0%iger Natronlauge in Äthanol erhalten.
ChemInform Abstract: PREPARATION OF NEW 2‐PYRIDYL AND PYRAZINYLHYDRAZONES CONTAINING FERROIN GROUP
Authors: CASE FRANCIS H.
Published: March 2016

Aus den Ketonen (I) werden die Hydrazone (II) dargestellt; die Hydrazone (III) bis (VII) werden analog (mit entsprechenden molaren Mengen des jeweiligen Hydrazins) gewonnen.