bluuebunny/crossref_metadata_2025 huggingface dataset:
TVET Skills Gap Analysis in Electrical and Electronic Industry: Perspectives from Academicians and Industry Players
Authors:   Faculty of Technology Management and Business, Universiti Tun Hussein Onn Malaysia, Parit Raja, 86400 Batu Pahat, Johor, MALAYSIA, Rodzalan Shazaitul Azreen , Mohd Noor Noor Nazihah ,   Faculty of Technology Management and Business, Universiti Tun Hussein Onn Malaysia, Parit Raja, 86400 Batu Pahat, Johor, MALAYSIA, Abdullah Nor Hazana ,   Faculty of Technology Management and Business, Universiti Tun Hussein Onn Malaysia, Parit Raja, 86400 Batu Pahat, Johor, MALAYSIA, Mohamed Saat Maisarah ,   Azman Hashim International Business School, Universiti Teknologi Malaysia, Skudai, 81310 Johor Bahru, Johor, MALAYSIA
Published: July 2022

Skills mismatch or skill gap is a long-standing issue whereby the levels and types of the existing skills do not meet the needs of the job market. With no exception, this issue also become one of the challenges that facing by Technical and Vocational Education and Training (TVET). If this issue prolongs, it will lead to graduate unemployment, specifically in TVET. Therefore, this study aims to identify the occupational skills (including both soft and hard skills) that are perceived as important by those in public Higher Education Institutions (HEI) and the electrical and electronic (E&E) industry which represent the manufacturing industry. A total of 58 academicians from public HEI and 55 industry players from the E&E industry in Malaysia were chosen purposively. These academicians and industry players were selected as they are having experience in occupational skill and training in their respective institutions and industries. Questionnaires were distributed online to these targeted respondents. The results revealed that there are skills gaps in terms of both soft and hard skills, which all skills are skills related to the career in E&E industry. The outcomes of this study should enable the Ministry of Higher Education, mainly in TVET to devise strategies to improve graduate employability. They might also serve as additional evidence for the occurrence of skills mismatch.
Lectotipificación y nuevos sinónimos de Serjania altissima (Sapindaceae)
Authors: Ferrucci María S. , Coulleri Juan P.
Published: July 2022

Se designa el lectotipo para el nombre perteneciente a la especie Serjania altissima (Poepp.) Radlk. y se proponen tres nuevos sinónimos.
The Impact of Value and Spiritual Approaches in the Change of Juvenile Delinquency
Authors: Alkatiri Muhammad Adnan , Maemonah Maemonah , Simbala Neni
Published: July 2022

This study aims to describe the efforts made by a teenager about his behavior changes that are more meaningful and religious as a result of the value and spiritual approaches. This study uses a descriptive qualitative method. Data were collected using observation and interview techniques to a single subject who experienced changes in behavior as a result of the two approaches.

The results reveal that the efforts to change the subject's behavior are driven by (1) feelings of guilt and deep regret when reminiscing about their juvenile delinquency, (2) various daily positive activities that have been carried out by the subject, and (3) a circle of friends and an environment that respects high social and spiritual values.
Lafaz Musytarak in Surah Al-Baqarah Verse 228 and Its Effect on Fiqh
Authors: Aspahani Aspahani , Fahrurrazi Fahrurrazi
Published: July 2022

Arabic is the richest language in the world with lots of vocabulary, so it cannot be denied that Arabic has a vocabulary with a variety of meanings which is commonly referred to as Lafzul Musytarak. Lafzul musytarak is a word or phrase that has two or more meanings. It is the same with the Qur'an which Allah sent down in Arabic containing various kinds of fiqh laws, but because of the lafaz musytarak in the Qur'an, there are differences of opinion among the scholars in establishing the law. Thus, produced legal products are also different. For example, the word Quru 'is contained in Surah Al-Baqarah verse 228. The pronunciation of Quru’ has a double meaning, It can be for the menstrual period or the holy period. Therefore, the opinion about the iddah period for women who are divorced and still have a menstrual cycle is also different. The results of this study indicate the iddah period for divorced women is different based on the inclination of the scholars in interpreting the word Quru'. Regarding this issue, Fuqaha 'ulama are divided into two opinions. Imam Malik and Shafi'i argue that the meaning of Quru' in Surah Al-Baqarah is a holy period, so the iddah period for divorced women is three times of the holy period. On the other hand, Imam Hanafi and Ahmad Bin Hanbal interpret Quru' as the period of menstruation. Therefore, the iddah period for divorced and menstrual women who are not menopausal is three menstrual periods.
The Abdolkarim Soroush's Perspective: Relationship of Reason, Freedom, and Islamic Democracy
Authors: Noor Fu'ad Arif
Published: July 2022

Abdolkarim Soroush has emerged as one of the world's leading moderate revisionist thinkers. He and his contemporaries in other Muslim countries formed what might be the equivalent of the Islamic Reformation of Christianity: the period of questioning traditional practices and beliefs that ultimately became an upheaval. Soroush's thoughts include the freedom of Muslims to interpret the Qur'an, the necessity of change in religion, the necessity of freedom of belief, and the compatibility of Islam and democracy. Soroush emphasized the rights of individuals in their relations with government and God, explaining that an ideal Islamic state can only be defined by the belief and will of the majority. The foundation always used by Soroush to explain his political theory is reason. It is the reason behind the modern man to do all his actions. Soroush distinguishes traditional man from modern man is using all his ability to change the world. Traditional people are more passive and deterministic, so they are pessimistic about the life of this world. Reason can not be sustainable if there is no freedom, faith under pressure and compulsion of religion is irrational. One will not be considered religious if he is irrational because it is rational and reason will manifest in the absence of coercion and restraint from religion
The Implication of Asbabun Nuzul for Al-Quran Verses Interpretation
Authors: Jamal Khairunnas , Mauliddin Arif Iman , Dalimunthe Derhana Bulan
Published: July 2022

This article aims to explore the existence of asbabun nuzul for the interpretation of Al Quran verses. The mufassir admits that without asbabun nuzul it will be difficult to understand the verses of the Qur'an. Therefore, this study reveals the implication of asbabun nuzul for interpretation. This article raises the issue of child's lineage to the ones who are the un-biological father. This study is library research by using articles and books as the primary sources. The results of this study show that asbabun nuzul has the primary authority in the interpretation such as clarifying the understanding of the process of legal determination, reviewing the specificity of the law, and rejecting the existence of hasr (legal restrictions) in the verses that contains legal barriers.
MAGISME ISLAM SASAK: FUNGSIONALISASI MANTRA QUR’ANISEBAGAI SOLUSI PROBLEMATIKA KEHIDUPAN MASYARAKAT PEDESAAN DI LOMBOK
Authors: Lestari Lestari , Jayanti Ervina Titi
Published: July 2022

ABSTRACTThe Sasak ethnic group in Lombok, West Nusa Tenggara, are fanatical adherents of Islam, especially rural communities. They believe in, understand and practice Islam based on the ideology of the Sufism which is synonymous with strong belief in mystical problems and spells in solving life problems faced. The Qur'an for rural Muslims, the Sasak ethnic group, is believed to be a magical tool in the form of a spell which if it can function as a solution to the problems of life. This study aims to reveal the factors that cause the birth of the practice of using Qur'anic spells and the forms of practice of using Qur'anic spells. This research is a field research related to socio-cultural problems. The approach used is religious anthropology and historical approaches. Methods of data collection are done by means of observation, interviews and documentation studies. The results showed that rural Muslims of the Sasak ethnic group adhere to the ideology of the sufism which is identical with a high belief in the benefits of the Qur’anic spell as a solution to life problems experienced, such as functioning as a treatment for diseases that are medical and non-medical in nature, to protect themselves or as a means of supernatural powers. As a way for the sake of getting a mate, used to get offspring, and as a means of house keeping.Keywords: Magism; Qur’anic spell, Sasak ethnicABSTRAKEtnis Sasak di Lombok Nusa Tengga Barat tergolong penganut agama Islam yang fanatik, terutama masyarakat pedesaan. Mereka meyakini, memahamai dan mengamalkan Islam berdasarkan faham tarekat yang identik dengan keyakinan yang kuat pada masalah mistik dan mantra dalam menyelesaikan problematika kehidupan yang dihadapi. Al-Qur’an bagi Muslim pedesaan etnis Sasak diyakini sebagai alat magis dalam bentuk mantra yang jika bisa berfungsi sebagai solusi bagi problematika kehidupan.Penelitian ini bertujuan untuk mengungkap faktor-faktor penyebab lahirnya praktik penggunaan mantra Alquran dan bentuk-bentuk praktik penggunaan mantra Alquran. Penelitian ini merupakan penelitian lapangan yang berkaitan dengan masalah sosial budaya. Pendekatan yang digunakan adalah antropologi Agama dan pendekatan sejarah. Metode pengumpulan data dilakukan dengan cara observasi, wawancara dan studi dokumentasi. Hasil penelitian menunjukkan bahwa muslim pedesaan etnis Sasak menganut faham tarekat yang identik dengan kepercayaan yang tinggi pada manpaat mantra Quranisebagai solusi bagi problematika kehidupan yang dialami, seperti berfungsi sebagai pengobatan penyakit yang bersifat medis dan non medis, untuk melindungi diri atau alat kesaktian, untuk dijadikan sebagai pelet demi mendapatkan jodoh, dipergunakan untuk mendapatkan keturunan, dan sebagai alat penjaga rumah.Kata Kunci: Magisme; MantraQur’ani; EtnisSasak
Sikap Toleransi dalam Menyambut Hari Pertama Puasa Bulan Ramadhan antara Jama’ah Nahdatul Ulama dan Jama’ah Muhammadiyah di Kabupaten Sleman (Tolerance in Welcoming the First Day of Fasting in the Month of Ramadan between the Nahdatul Ulama and the Muhammadiyah Jama'ah in Sleman Regency)
Authors: Sulaiman Sulaiman , Ihsan Akmal , Izah Syafira Anisatul , Hatba Muhammad As’ad
Published: July 2022

This study aims to describe the phenomenon in a multicultural society that coexists with different organizations. This is descriptive qualitative research that collects data in the field. Data collection techniques include in-depth interviews, observation, and documentation. The data were analyzed through the stages of data reduction, data display, and concluding. The results indicate that the unification of the Hijri calendar has been carried out since 2014, in the last 7 years, Jama’ah of NU and Muhammadiyah have welcomed the first day of fasting together at the same time. However, in 1443 Hijri, the reception of the first day of fasting for Jama’ah of NU and Muhammadiyah was different. Because NU uses Ru'yatul Hilal while Muhammadiyah uses Hisab in determining the first day of fasting, these differences cause various discourses of response in the implementation of the first day of fasting. Intra-religious dialogue upholds religious tolerance. The general conclusion is that intra-religious dialogue is a forum for knitting peace between Jama’ah of NU and Muhammadiyah in creating social relations and religious interactions. It became a positive response from Jamaah of NU and Muhammadiyah. Even Jamaah of NU and Muhammadiyah together welcomed the first day of fasting in knitting religious tolerance.
Upaya Penghapusan Kekerasan Seksual Melalui Implementasi Program Pemberdayaan Perempuan
Authors: Banuarli Naufal Asyiri , Ariana Ariana , Alfiyani Nur , Zulfikar Achmad
Published: July 2022

The role is a dynamic aspect, where the role is carried out based on the position/position attached, so when someone has carried out his function in accordance with the inherent status in himself, then he is said to have carried out a role. The role is more emphasis on community expectations of individuals, where the community expects the individual to be able to change the social order of the role he does. The role can certainly be done by everyone without exception, including the role of women leaders in fighting for women's interests. The intended role in this research is the efforts of female leaders in supporting efforts to eliminate sexual violence. This research was conducted in Makassar City. The method used is descriptive method with a qualitative approach. The technique used in data collection is through in-depth interviews with several informants as well as from other sources related to this research.The results showed that in supporting efforts to eradicate sexual violence, women leaders in Makassar had made efforts such as the Women's Change House (RPP) program, the Anti Sexual Violence campaign, Mother's School, and Parenting Education. While the program that will be carried out by female leaders is by holding a Mother School program.

Abstrak

Peran merupakan suatu aspek dinamis, dimana peran dilakukan berdasarkan posisi/ jabatan yang melekat, jadi ketika seseorang telah menjalankan fungsinya sesuai dengan status yang melekat dalam dirinya, maka ia dikatakan telah menjalankan suatu peranan. Peran lebih menekankan kepada pengharapan masyarakat terhadap individu, dimana masyarakat mengharapkan individu tersebut mampu merubah tatanan sosial atas peran yang dilakukannya. Peran tentu dapat dilakukan semua orang tanpa terkecuali, termasuk peran tokoh perempuan dalam memperjuangkan kepentingan perempuan. Peran yang dimaksudkan dalam penelitian ini yaitu upaya para tokoh perempuan dalam mendukung upaya penghapusan kekerasan seksual. Penelitian ini dilaksanakan di Kota Makassar. Metode yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Teknik yang digunakan dalam pengumpulan data yakni melalui proses wawancara mendalam (indepht interview) kepada beberapa informan serta dari sumber-sumber lain yang berhubungan dengan penelitian ini. Hasil penelitian menunjukkan bahwa dalam mendukung upaya penghapusan kekerasan seksual, para tokoh perempuan di kota Makassar telah melakukan upaya seperti program Rumah Perubahan Perempuan (RPP), kampanye Anti Kekerasan Seksual, Sekolah Ibu, dan Parenting Education. Sedangkan program yang akan dilakukan para tokoh perempuan yaitu dengan mengadakan program Sekolah Ibu.
Manajemen Konflik Siswa oleh Kepala Madrasah
Authors: Potabuga Handoyo , Kusnan Kusnan , Kryati Lies
Published: July 2022

Conflicts among students are prone to occur in the school environment so principal needs to have concern that he can implement the student management. Using a qualitative approach, this study focuses on the background of student conflict and the leadership role of the Head of Madrasah Tsanawiyah Alkhairaat Langagon in overcoming student conflict. This study uses observation and interviews as data collection instruments. Based on the analysis of the data results that the authors present, several conclusions can be drawn that first, the background to the emergence of student conflicts at MTs Alkhairaat Langagon, is usually due to the lack of teacher supervision of students. Because many teachers have financial difficulties that forces them to have second job. Second, the madrasah principal communicate well and successively with the conflicting parties so that decision making is satifying.

Abstrak

Konflik antar siswa rentan terjadi di lingkungan sekolah sehingga perlu menjadi perhatian Kepala Sekolah dalam penyelenggaraan manajemen kesiswaan. Dengan menggunakan pendekatan qualitatif, penelitian ini berfokus pada latar belakang konflik siswa dan peran kepemimpinan Kepala Madrasah Tsanawiyah Alkhairaat Langagon dalam mengatasi konflik siswa. Penelitian ini menggunakan observasi dan wawancara sebagai instrumen pengumpul data. Berdasarkan analisis hasil data yang penulis sajikan, dapat ditarik beberapa kesimpulan bahwa pertama, yang melatarbelakangi timbulnya konflik siswa di MTs Alkhairaat Langagon, biasanya karena kurangnya pengawasan guru terhadap siswa. Karena banyak guru yang memiliki kesulitan ekonomi sehingga melaksanakan kegiatan lain di luar lingkungan pendidikan untuk menunjang pendapatan. Kedua, pengelolaan konflik yang dilakukan oleh kepala madrasah ketika terjadi konflik adalah dengan melakukan komunikasi secara baik dan beruntun dengan pihak yang berkonflik sehingga pengambilan keputusan sesuai yang dibutuhkan.
Pengenalan Pola Hidup Bersih dan Sehat Melalui Exprimen Sains pada Anak Usia Dini di Kelompok B TK Putri Ramadhani
Authors: Ashari Novita , Sari Putri Indah , Asnar Armi Nadilah , Harianti Harianti , Megawati Megawati , Mogawani Mogawani , Kholilah Ema Ainun , Widyarni Lisma
Published: July 2022

The lack of knowledge and understanding of children in Putri Ramadhani Kindergarten about Clean and Healthy Living Behavior (PHBS) is because children have not been motivated to maintain a clean and healthy lifestyle, children have not carried out direct experiments on maintaining cleanliness. Children are only introduced through visual images. The purpose of this study was to provide understanding to children about a Clean and Healthy Lifestyle through scientific experiments. The implementation of the introduction of a healthy and clean lifestyle that has been carried out at the Putri Ramadhani Kindergarten has been carried out well by the children, this is shown in the increase in the cleanliness of children aged 4-5 in the Putri Ramadhani Kindergarten which amounted to 10 children. Of the 4 indicators of clean and healthy living that children are accustomed to, namely washing hands before eating without being asked, knowing the order of washing hands, closing their own lunch after eating without being asked, knowing the dangers of germs, viruses, and bacteria.

Abstrak

Kurangnya pengetahuan dan pemahaman anak di TK Putri Ramadhani tentang Perilaku Hidup Bersih dan Sehat (PHBS) hal tersebut dikarenakan anak belum termotivasi untuk menjaga pola hidup bersih dan sehat anak belum melakukan eksprimen langsung tentang menjaga kebersihan. Anak hanya di kenalkan melalui visual gambar saja. Tujuan penelitian ini adalah untuk memberikan pemahaman kepada anak Pola Hidup Bersih dan Sehat melalui ekperimen sains. Pelaksanaan pengenalan pola hidup sehat dan bersih yang telah dilakukan pada TK Putri Ramadhani telah terlaksanakan dengan baik oleh anak, hal ini ditunjukkan pada kebersihan anak usia 4-5 di TK Putri Ramadhani yang berjumlah 10 anak meningkat. Dari 4 indikator hidup bersih dan sehat yang dibiasakan anak yaitu mencuci tangan sebelum makan tanpa disuruh, mengetahui urutan mencuci tangan, menutup bekal sendiri setelah makan tanpa disuruh, mengetahui bahaya kuman, virus, dan bakteri.
The “SEED” Study: The Feasibility of Selecting Patient-Specific Biologically Targeted Therapy with Sorafenib, Everolimus, Erlotinib or Dasatinib for Pediatric and Young Adult Patients with Recurrent or Refractory Brain Tumors
Authors: Cole Bonnie L. , Starr Kimberly , Lockwood Christina M. , Leary Sarah E. S.
Published: July 2022

Background: Pediatric brain tumors are the leading cause of cancer death in children and represent a variety of diseases and molecular subtypes. This study sought to evaluate a rapid immunohistochemistry testing panel to aid in therapy selection at the time of malignant tumor recurrence. Methods: With IRB approval and appropriate informed consent, we conducted a single-institution prospective clinical trial of selected kinase inhibitor therapy. A laboratory-developed immunohistochemical testing panel was performed on tumor tissue, and therapy with one of four small molecule inhibitors was recommended in combination with oral chemotherapy consisting of temozolomide and etoposide. Results: All 20 enrolled subjects were assigned to Everolimus (n = 4), Erlotinib (n = 6) or Dasatinib (n = 10); 90% (18/20) within the pre-specified 14-day feasibility time period. Only two subjects elected treatment on study, 8 received targeted treatment based on testing results either alone (n = 5) or in combination with chemotherapy (n = 3). Other subjects received chemotherapy alone (n = 7), surgery alone (n = 2) or no further therapy (n = 3). Immunohistochemical targets were associated with correlative genetic changes in 28% (5/18) of those evaluated. Conclusions: It was feasible to rapidly select targeted therapy in recurrent pediatric brain tumors, but not feasible to treat with a uniform combination treatment regimen.
Adrenomedullin is an Important Pathological Mediator in Progression of Chronic Neuropathic Pain
Authors: Wang Chunmei , Xue Yaping , Lu Qiuhua , Shi Yonghui , Tang Wei , Wang Dongmei
Published: July 2022

Background: The characterization of neuropathic pain is maladaptive plasticity within the nociceptive system. Multiple alterations contribute to complex pain phenotypes. Adrenomedullin (AM) has been documented to be a pain mediator. However, its involvement in pathological pain is poorly understood. We studied the contribution of AM to chronic neuropathic pain in the spinal nerve ligation (SNL) model. Methods: Daily injection of the AM receptor antagonist AM22-52 (10 nmol) via an intrathecal (i.t.) route after SNL inhibited mechanical allodynia starting on day 6. Single administration of AM22-52 produced an immediate attenuation on pain hypersensitivity on day 2 or 10 post-SNL. Protein and mRNA levels were assayed by immunofluorescent staining and qRT-PCR, respectively, on days 1, 3, 7 and 15 post-SNL. Results: The results showed that AM at both protein and mRNA levels was increased in both injured (L5) and adjacent uninjured (L4) nerves starting on day 3 post-SNL. In dorsal root ganglion (DRG) at L5, AM was increase on days 1–7 at mRNA level but only on day 7 at protein level. However, AM was increase at mRNA level on days 1–7 and at protein level on days 3–15 in L4 DRG. AM mRNA expression was upregulated on days 1–7 in the spinal cord. Expression of receptor activity-modifying protein 2 (RAMP2), an essential AM1 receptor component, was upregulated in small and medium-diameter neurons on days 1–15 in both L5 and L4 DRG. Furthermore, single administration of AM22-52 suppressed the increase of nNOS in DRG induced by SNL and daily injection of AM22-52 for 7 days inhibited SNL-induced increase of CGRP mRNA in the spinal dorsal horn. Conclusions: This study indicates that the increased AM bioactivity in injured and uninjured peripheral nerves, uninjured adjacent DRG and the spinal dorsal horn play a critical role mainly in the late-phase development of neuropathic pain. The mechanism may involve the recruitment of nNOS and CGRP.
Remote sensing and in-situ approach for investigation of pelagic communities in the reservoirs of the electrical power complex
Authors: Protasov Alexander , Tomchenko Olha , Novoselova Tatiana , Barinova Sophia , Singh Sudhir Kumar , Gromova Yulia , Curtean-Bănăduc Angela
Published: July 2022

Background: Two closely located reservoirs on the Southern Bug River and its tributary in the southern region of Ukraine were compared to study the impact of temperature on hydrobionts and pelagic communities, a major ecologic issue in the climate warming context, using in-situ and satellite remote sensing data. These reservoirs are parts of the South-Ukraine electric power-producing complex. The Tashlyk reservoir is a cooling reservoir for the nuclear power plant, and Oleksandrivske reservoir is used for production of hydroelectricity and irrigation. The cooling reservoir is replenished by pumping water from the upper part of the Oleksandrivske reservoir. Methods: The relationships of temperature, transparency, and distribution of phytoplankton and zooplankton communities were established based on satellite remote sensing data and in-situ during 2013–2021. The main variables of phytoplankton and zooplankton were compared, and for improved understanding features, spatial distribution maps were created. Results: It was found that the distribution of coenotic groups of phytoplankton and zoonplankton in the cooling reservoir (Tashlyk) corresponds to thermal conditions. Three communities of phytoplankton and two communities of zooplankton were identified in the Tashlyk reservoir. However, in the Oleksandrivske reservoir, separate communities of phytoplankton and zooplankton were reported along its length. Conclusions: It was shown that both on land and in the Oleksandrivske reservoir, there is an increase in temperature in summer, an increasing trend in the global warming context, but that was not observed in the cooling reservoir of the nuclear power plant (NPP). It let us assume that the factors such as temperature or nutrients impact can be assessed as external significant factors related to the catchment area for the reservoirs with different types of using.
Potential Mechanisms by which Glucocorticoids Induce Breast Carcinogenesis through Nrf2 Inhibition
Authors: Giudice Aldo , Aliberti Silvana Mirella , Barbieri Antonio , Pentangelo Paola , Bisogno Ilaria , D’Arena Giovanni , Cianciola Emidio , Caraglia Michele , Capunzo Mario
Published: July 2022

Breast cancer is the most common malignancy among women worldwide. Several studies indicate that, in addition to established risk factors for breast cancer, other factors such as cortisol release related to psychological stress and drug treatment with high levels of glucocorticoids may also contribute significantly to the initiation of breast cancer. There are several possible mechanisms by which glucocorticoids might promote neoplastic transformation of breast tissue. Among these, the least known and studied is the inhibition of the nuclear erythroid factor 2-related (Nrf2)-antioxidant/electrophile response element (ARE/EpRE) pathway by high levels of glucocorticoids. Specifically, Nrf2 is a potent transcriptional activator that plays a central role in the basal and inducible expression of many cytoprotective genes that effectively protect mammalian cells from various forms of stress and reduce the propensity of tissues and organisms to develop disease or malignancy including breast cancer. Consequently, a loss of Nrf2 in response to high levels of gluco-corticoids may lead to a decrease in cellular defense against oxidative stress, which plays an important role in the initiation of human mammary carcinogenesis. In the present review, we provide a comprehensive overview of the current state of knowledge of the cellular mechanisms by which both glucocorticoid pharmacotherapy and endogenous GCs (cortisol in humans and corticosterone in rodents) may contribute to breast cancer development through inhibition of the Nrf2-ARE/EpRE pathway and the protective role of melatonin against glucocorticoid-induced apoptosis in the immune system.
Quantitative Analysis of Biofilm Removal Following Instrumentation with TRUShape and Vortex Blue File Systems: Microbiological Study
Authors: Bullard Shaun , Mona Mahmoud , Pereira Andrea C. , Kajfasz Jessica , Lemos Jose A. , Abranches Jacqueline , Wallet Shannon M. , Pileggi Roberta
Published: July 2022

Mesial roots and isthmuses of mandibular molars are difficult areas to obtain adequate disinfection of root canal walls, and consequently microorganisms can survive treatment. The present study compared, through real-time polymerase chain reaction (qPCR), the effectiveness of TRUShape (TS) (Dentsply Tulsa Dental Specialties, Tulsa, OK) and Vortex Blue (VB) (Dentsply Tulsa Dental Specialties, Tulsa, OK) in removing Enterococcus faecalis (E. faecalis) from the mesial canals and isthmuses of mandibular molars. Fifty extracted human lower molars were inoculated with E. faecalis OG1RF for 14 days, and then an initial bacterial sample was collected with paper points from mesiobuccal and mesiolingual canals and isthmuses. The specimens were randomly divided into four groups (n = 10 teeth; 20 canals each), according to instrumentation system: TS 25/0.06, TS 30/0.06, VB 25/0.06 and VB 30/0.06. The remaining 10 teeth were divided between positive control, inoculated teeth without instrumentation or irrigation, and negative controls, teeth without inoculation. After instrumentation, the final sample was taken using paper points and DNA was isolated. Primers specific for E. faecalis were used for qPCR. The bacterial reduction between pre- and post-instrumentation was calculated. One-way analysis of variance (ANOVA) with Bonferroni’s multiple-comparisons tests were for statistical analysis with significance of (p < 0.05). All file systems were able to reduce the load of E. faecalis from the prepared root canals, however, TS size 30 removed significantly more bacteria than size 25. Interestingly, regardless of the size, TS files removed significantly more E. faecalis biofilm (p < 0.05) than did VB files (63.7% vs 50.8% for size 25, and 69.5% vs 56% for size 30). In conclusion, when combined with irrigation, TS file system is more effective than VB in reducing E. faecalis biofilms from mesiobuccal and mesiolingual canals and the isthmuses of mandibular molars.
PARTISIPASI PELAKU USAHA KECIL DALAM PEKERJAAN KONSTRUKSI PEMERINTAH DI KEMENTERIAN KEUANGAN
Authors: Aprilia Rachma , Johantri Bagas
Published: July 2022

Tujuan penelitian ini untuk mengkaji perbedaan rata-rata jumlah peserta tender pekerjaan konstruksi bagi kualifikasi usaha kecil pada periode sebelum dan sesudah pemberlakuan Perpres 12 Tahun 2021. Untuk memastikan persaingan di pasar berjalan sesuai dengan tujuannya, pihak-pihak tertentu perlu melakukan intervensi dengan menetapkan aturan kompetisi. Peraturan Presiden 12 Tahun 2021 merupakan bentuk intervensi pemerintah untuk meningkatkan partisipasi usaha kecil dalam pengadaan pemerintah sebagaimana diamanatkan oleh Undang-Undang Cipta Kerja, yang bertujuan untuk memperluas kemudahan berusaha dan pemerataan ekonomi. Penelitian ini menggunakan data sekunder tender pekerjaan konstruksi di Kementerian Keuangan periode Januari 2019 – Oktober 2021. Makalah ini menggunakan uji statistik parametrik Independent Sample T-test. Hasil penelitian menunjukkan perbedaan yang signifikan rata-rata jumlah peserta sebelum dan sesudah pemberlakuan Perpres 12 Tahun 2021 dalam tender pekerjaan konstruksi untuk kualifikasi kecil. Bagi pemerintah, penelitian ini dapat menjadi gambaran awal dampak kebijakan Perpres 12 Tahun 2021 terhadap usaha kecil di Indonesia
THE STRUGGLE OF THE REPRESSIVE AND PUNITIVE ORGANS OF THE SOVIET STATE AGAINST THE UKRAINIAN INSURGENT MOVEMENT (1945 – MID 50'S OF THE TWENTIETH CENTURY)
Authors:   Сумський державний педагогічний університет імені А.С. Макаренка, Ярош Наталія
Published: July 2022

The article is devoted to the study of the peculiarities of the struggle of the repressive and punitive bodies of the Soviet state against the Ukrainian insurgent movement in the first post war decade. After the end of World War II, Ukrainian insurgents continued their armed struggle against the Soviet totalitarian regime. But punitive actions by the Soviet regime did not stop the insurgents. Simultaneously with the communist election campaign, the Ukrainian armed underground distributed its leaflets, carried out attacks by agitation and propaganda groups, and polling stations. One of the most insidious methods used by the punitive and repressive authorities of the Soviet state was the creation and operation of special groups that operated under the guise of UPA units or OUN Security Service militants. New forms of struggle also provided for operations by small shunting units of the MGB against specific insurgent formations, or individual underground activists, primarily district, district and regional OUN leaders, whose location was identified by the agency or special groups. In general, the repressive authorities chieved some results. The Soviet government gave a significant place in the fight against the OUN-UPA to fighter battalions from the local population, the formation of which began in 1944, and special groups that included former insurgents. The government's hopes for the rapid and complete destruction of the liberation movement did not materialize, as it enjoyed the support of the population and, in turn, chose the optimal model of functioning in the relevant period. That is why the repressive and punitive apparatus changed its own tasks during the struggle against Ukrainian nationalists. These changes gave the Soviet security forces the opportunity, acting in small groups, with accurate intelligence data, to cover a larger area and eliminate the remaining nationalists. In the mid-1950s, the Soviet state was able to destroy the main centers of the Ukrainian insurgent movement and establish a totalitarian regime throughout Ukraine.
US FOREIGN POLICY STRATEGY IN THE FAR EAST IN 1901–1904
Authors:   Сумський державний педагогічний університет імені А.С. Макаренка, Жуков Олександр
Published: July 2022

The article is devoted to the peculiarities of the formation of US Far Eastern policy in the early twentieth century. The author identifies the transformation of the country's foreign policy from isolationism to active action as key aspects of the study. Determining the strategic need of the United States to gain a foothold in the Far East reveals the main foreign policy vectors. A special role in this was played by US President Theodore Roosevelt and Secretary of State John Hay, who were the ideologues of the new, "Pacific era" and "open door" policy, particularly in China, which should have led to the beginning of the "American century". Achieving these goals was possible by maintaining friendly relations with Britain and Japan as opposed to Russia. Such a strategy weakened the position of the latter in the region and, as a consequence, increased US trade with the countries of the Far East. The article also considers the main events that led to the beginning of the Russo-Japanese War of 1904-1905 and the role of the United States in it, which sought to gain a foothold in the Far East through flexible diplomacy. The author notes the main successes in this direction, in particular, the assessment of the talks between the US Secretary of Defense W. Taft and the Prime Minister of Japan T. Katsura both at the official and unofficial levels. Particular attention is paid to the economic component in the relationship between the Far East (including China) and official governmental and private organizations in the United States. The author notes that, in fact, US policy in China and Japan did not differ from the policy of Western European countries, but the forms and methods of their expansion were different. The study of this problem is important both for studying the peculiarities of US policy in Asia in the past, and for understanding current international relations in the Far East.
GENERAL DECLARATION OF HUMAN RIGHTS ADOPTION: HISTORICAL ASPECT
Authors:   Сумський державний педагогічний університет імені А.С. Макаренка, Кучук Андрій
Published: July 2022

The urgency of the study is stipulated by the necessity to cover the process of project preparation and adoption of the Universal Declaration of Human Rights, which will allow a comprehensive study of the nature of human rights, to understand their universal nature. The choice of the Universal Declaration of Human Rights as an object of the study is determined by the special nature of this international soft law act. It is emphasized that the process of adopting this international act remains somewhat unclear among lawyers. The preparation and adoption of the Universal Declaration of Human Rights is hardly covered in the legal literature, which does not contribute to a comprehensive understanding of the Western human rights concept and relativism in the interpretation of human rights as a phenomenon within various legal cultures. Some aspects of project preparation and adoption of the Universal Declaration of Human Rights are described. The activities of the Human Rights Commission, which consisted of 18 members representing various political, cultural and religious groups, are noted. It is emphesized that starting with Art.1 of the Universal Declaration of Human Rights from the words “All people are born free and equal…”, the developers of the Universal Declaration of Human Rights reproduced the idea of the universality of human rights, their global nature, that is not limited to a state or even a region. It is summed up that representatives of various groups of the population were involved in the work on the text of the document, creating an international act that was to consolidate human rights, to embody the ideas of equality of human rights, and their universal character. However, while adopting the Universal Declaration of Human Rights, not all states voted in its favor. Eight states have refrained from supporting it which is stipulated by a number of religious and political factors. At the same time, different interpretations of human rights by various states do not deny their universal nature. Covering the issue of human rights, it is advisable to disclose the process of preparation and adoption of the Universal Declaration of Human Rights, which will allow systematically and clearly understand the nature of human rights, differences in the activities of various states concerning human rights ensuring.
PERGAMON AND THE EASTERN BLACK SEA(GONIO-APSAROS)
Authors:   Batumi Shota Rustaveli State University Library, Ebralidze Tariel , Sikharulidze Khatia ,   Batumi Shota Rustaveli State University Library
Published: July 2022

Pergamon has been known as one of the major centers of ceramic production since Hellenistic times. It falls first to the Roman Empire after the defeat of Pontus, and after the defeat of Mithridates VI Eupator. It was one of the important centers that supplied troops of imported pottery, such as red-lacquered pottery and powder, to soldiers stationed in the eastern part of the Roman Empire, in the northern regions of Asia Minor, and in Roman fortress cities in the Caucasus.
STRATEGIC PARTNERSHIP BETWEEN CHINA, THE EU AND THE UNITED STATES IN THE FIELD OF ENERGY AND INTERNATIONAL ENVIRONMENTAL PROTECTION (2000 - 2016)
Authors:   Sumy State Pedagogical University named after A.S. Makarenko, Podriez Yulia , Zhukov Alexander ,   Sumy State Pedagogical University named after A.S. Makarenko
Published: July 2022

The energy policy of the EU, China and the USA during 2000–2016 before the presidency of Donald Trump was analysed in the article. The common feature of the energy policy is its focus on strengthening integration processes to create a common energy policy, single market and sustainable development of countries. The EU’s energy policy is based on the priorities related to a guaranteed and secure supply of gas, oil and electricity. The author proposes six priority areas for cooperation: the formation of a single energy market, security of supply, diversification of energy resources, climate change issue, development of new technologies and formation of a common foreign policy as well as approaches to energy. In our opinion China adheres to the similar policy of reducing energy consumption and harmful emissions while increasing the share of «green energy», but it goes along with some differences, namely, China will continue to build nuclear power plants (NPP) and will not abandon coal-fired power plants (CFPP) for at least the next 20 years. Today, the European Union is one of China’s most important partners. In view of the above, the article also considers the process of trade and economic cooperation between the two parties. This study also presents the cooperation of American and Chinese companies in the energy sector, which differentiated the views of American analysts on the future of the relations between China and the USA. «Pessimists» believe that it is difficult for superpowers to coexist when their interests clash with vital natura l resources. According to them, it is almost impossible to avoid a future confrontation between China and the USA. «Optimists» are sure that the huge Chinese market is so vital to the American economy that the USA is interested in the Chinese economy to grow steadily, providing new opportunities for potential American investors.
Primary CNS Lymphoma of Diffuse B cells in a Patient with Neurofibromatosis Type 1: A Case Report.
Authors: Ramirez-Loera Cristopher , Sandoval-Lopez Diego A. , Mejía-Pérez Sonia I.
Published: July 2022

Objective: To describe the case of a patient diagnosed with Neurofibromatosis Type 1 (NF1), who developed her first neoplastic lesion as Primary Central Nervous System Lymphoma (PCNSL). To our knowledge, this is the third case of PCNSL in the context of NF1.
Background: PCNSL represents 1% of non-Hodgkin extranodal Lymphomas, and 3% of CNS tumors. Diffuse Large B-Cell Lymphoma accounts for 30-40% of the cases, commonly found in the encephalus, spinal cord, leptomeninges, or the eye. Predominant malignant tumors in NF1 are gliomas and Malignant Peripheral Nerve Sheath Tumor (MPNST).
Methods: A 53-year-old Mexican female, with a history of NF1, arrived at the emergency department with left-side subacute progressive numbness and weakness. Left hemiplegia. MRI showed a ring-enhancing lesion in the right central lobe and a lesion in the subcutaneous tissue. Additionally, the patient underwent a full body 18-FDG PET scan, which reported activity only in the CNS. 
Results: Lesion-centered craniectomy and surgical evacuation were performed. Histopathological examination revealed lymphoid lineage cells, CD20, PAX-5, and Ki-67 were positive for neoplastic cells, confirming the diagnosis of PCNSL. At the 6-months follow-up visit, strength improved significantly, and the follow-up MRI did not show residual mass. 
Conclusions: It is necessary to study the prevalence of LPSNC in these patients, as well as the relative risk, and to develop guidelines for its best approach. We believe that the real incidence of the disease is underestimated, since the genetic and pathophysiological mechanisms that promote its origin still need to be clarified.
Therapeutic potential of cannabinoids for stroke: scoping review protocol
Authors: Pérez-Neri Iván , Estêvão M. Dulce , Mishra Rakesh , Sandoval Hugo , Zárate Manuel , Ríos Camilo
Published: July 2022

Introduction: Each year, approximately 795,000 people experience a new or recurrent stroke, either ischemic or hemorrhagic. The current therapeutical approach for acute ischemic stroke includes thrombolysis and mechanical thrombectomy; still, no neuroprotective treatment options currently exist to improve its neurological outcome. Some components of the endocannabinoid system are altered after ischemic stroke. It is considered that cannabinoids may exert neuroprotective effects; however, the use of cannabinoid receptor ligands is a major concern due to its psychotropic properties. Regardless that there are many studies describing the benefit of administering cannabinoids for experimental stroke several unanswered questions remain since most of the information point up in non-human species. A previous systematic review detected significant heterogeneity among studies, so it is appropriate to perform a scoping review to evaluate the feasibility of performing an updated systematic review and meta-analysis. This scoping review aims to evaluate the therapeutic potential of modulating the endocannabinoid system for stroke. Methods: Published studies (all publication types) will be retrieved from Web of Science, PubMed, Scopus, Ovid, EBSCOhost, and Google Scholar. Eligibility criteria: Clinical or preclinical studies reporting endocannabinoid levels or their effects, or reporting administration of cannabinoid modulators (stimulating or inhibiting their synthesis or metabolism, phytocannabinoids, or synthetic cannabinoids), in patients or models of stroke will be considered for inclusion. Studies written in languages different than Spanish or English that could not be appropriately translated, or whose full-text files could not be retrieved will be excluded. Data charting: Results will be summarized in tabular form. This protocol complies with PRISMA-P.
Sürdürülebilir Ulaşım Altyapısının Pandemi Döneminde Yeniden Kurgulanması: Mikromobilite Trendleri ve Türkiye
Authors: ÖNDER Hatice , AKDEMİR Furkan
Published: July 2022

Bu çalışmada, ulaşımın önemli bir boyutu olan mikromobilite kavramının güncel etkiler göz önünde bulundurularak, Türkiye perspektifinde teorik bir değerlendirmesi yapılmıştır. Amaç mikromobilite kavramına ilişkin şehircilik açısından yeni teorilerin geliştirilme ve değerlendirilmesi, mevcut mikromobilite yaklaşımlarının incelenmesiyle, Türkiye’de mikromobiliteye ilişkin ne tür düzenlemelerin yapılabileceği konusunda öneriler geliştirmektir. Dolayısıyla, daha önce mikromobilite konusunda yapılmış çalışmaların irdelenmesi ve COVID-19 Pandemisi döneminde mikromobilitenin kentsel ulaşım üzerine olan etkisinin, sayısal sonuçlarının değerlendirmesi yapılmıştır. COVID-19 Pandemisi kaynaklı olarak kentsel ulaşımda, özel taşıt kullanımında artışın gözlendiği durum, trafik sıkışıklığı ve çevresel kirliliklerde de ciddi düzeyde artışa neden olmuştur. Bu durum dünya kentleri için büyük sorunlar oluşturmuştur. Çalışma kapsamında yapılan incelemelerde 20 ülkenin 15’inde özel taşıt kullanım oranının arttığı, 17’sinde yaya kullanımının arttığı görülmektedir. Sadece 8 ülkede toplu taşıma kullanımında artış olduğu görülmektedir. Plan hiyerarşisi açısından her bir ölçekte konunun gündeme gelmiş ve çalışılmış olması, önemli bir adım olarak değerlendirildiğinde mikromobilite açısından Türkiye’de %80’lik bir yönetsel düzeyin varlığından bahsedilebilir. Türkiye'de mikromobilite konusunda bisiklet, scooter ve diğer türler (unicycle, kaykay vb.) konusunda taşıtlar gruplandığında, yasal ve yönetsel çerçevenin %66’lık bir düzeyde olduğu görülmektedir. Türkiye’de kentlerin %24,7’sinde elektrikli scooter işletiminin varlığının olması bize mevcut durumda olumlu gelişmelerin olduğunu göstermektedir.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CARDIOVASCULAR PATHOLOGY WITH FOCUS ON ARRHYTHMIAS
Authors: Dmytriiev K. D. , Slepchenko N. S.
Published: July 2022

Chronic obstructive pulmonary disease is a third leading cause of death worldwide according to the WHO data. But often the direct mortality cause in these patients is cardiovascular complications, including arrhythmias. The aim of the study was to evaluate the concomitant cardiovascular pathology with focus on arrhythmia in patients with COPD. Materials and methods. 100 COPD patients were enrolled, mean age (64,09 ± 1,94) years, 66 male (66 %) and 34 female (34 %). There were 68 smokers (68 %), mean smoking duration — (24,44 ± 4,84) pack-years. Mean COPD duration — (9,35 ± 2,42) years. Source medical document data analysis regarding ongoing cardiovascular conditions was conducted. Results. Arterial hypertension was the most prevalent concomitant cardiovascular condition in COPD patients (77 %). Ischemic heart disease was the second by prevalence (67 %). Heart failure, as possible complication of pulmonary hypertension, cor pulmonale and/or cardiovascular conditions was found in 70 % of cases. Atrial fibrillation was observed in 18 % patients with COPD. Most patients suffered from atrial fibrillation with ventricular tachysystolia (14 %), which was quite typical for COPD due to hypoxia-related sympathetic nervous system activation. Conclusions. COPD and cardiovascular conditions have common pathogenetic mechanisms, leading to the occurrence of the mutual risks. COPD increases the risk of cardiovascular diseases progression and, conversely, presence of cardiovascular disease increases risk of COPD worsening. This connection creates a vicious circle of these diseases progression. Key words. COPD, cardiovascular diseases, arrhythmias.