bluuebunny/crossref_metadata_2025 huggingface dataset:
SISTEMA DE ENSINO A DISTÂNCIA (EAD) EM TEMPOS DE PANDEMIA
Authors: Quagliarello Giancarlo
Published: March 2022

A pandemia advinda da doença do coronavírus 2019 (Covid-19) tornou a vida uma verdadeira epopeia e algumas perguntas estão sendo feitas sobre a vida e o comportamento após essa pandemia: (a) Como devemos e como teremos de nos comportar a partir de então?; (b) Como será a vida depois que essa pandemia terminar?; (c) Como pode ser a comunicação com as pessoas?; (d) Como ensinar nossos filhos?; (e) Como será a educação, quando a pandemia terminar? Perguntas semelhantes serão feitas sobre a Educação. A quarentena é uma das armas mais eficientes no combate ao Covid-19, mas sua duração não foi considerada que seria por mais de meses. Escolas e universidades vêm enfrentando uma situação muito difícil de como promover a educação por meio do Sistema de Educação a Distância (EAD). Usar o EAD para que os alunos não fiquem sem estudar/aprender foi a maneira mais rápida e segura de manter a saúde e a educação do aluno até o momento. Este artigo discute o momento atual e como a situação pode ser reinventada diante do ensino e de novos desafios. Que problemas serão enfrentados? Uma análise será realizada por meio de revisão bibliográfica e pesquisa qualitativa e quantitativa sobre o novo cotidiano de professores e alunos, diante de EAD, seus desafios e enfrentamentos. A funcionalidade, capacidade e sociabilidade do método pela internet, as leis das diretrizes básicas de ensino e a socialização de alunos/professores serão estudadas. 603 norte Al 14 APM 11. Cep 77001-864 Palmas TO Brasil

Palavras-chave: Covid-19; EaD; educação; ensino; internet.
SEU LUNGA: a character in the transit between real life and cordel brochures
Authors: Fonseca Maria Gislene Carvalho
Published: March 2022

This article discusses the story of Seu Lunga in the cordel “The stories of Seu Lunga: the most angry man in the world”, written by Abraão Batista, the first poet to publish about the character. We understand cordel as a narrative communicational phenomenon of everyday records. We observe, through analysis based on the social construction of reality, disputes over meanings in the cordel about Seu Lunga, constituting a character as believable as mythical, using narrative strategies of effects of realness. We conclude that, by becoming a character, through the meanings that his name summons, Seu Lunga acquires permanence in the collective memory.
Apresentação: Dossiê Inovação em mídia na Ibero-América: mirando o futuro
Authors: Nunes Ana Cecilia Bisso , Flores Ana Marta Moreira , Villa María Isabel
Published: March 2022

Identificar, caracterizar e refletir criticamente sobre os processos inovadores da comunicação, da mídia e do jornalismo são os pontos centrais da edição temática de Inovação em mídia da Revista Observatório. O dossiê apresenta uma curadoria de quatro artigos que exploram os cenários no Brasil e na Colômbia com destaque para inovações nos campos prático, acadêmico, social e econômico, onde são mostradas novas formas de aprendizagem mediadas por tecnologias, a criação de modelos de negócios e expansão transmídia de conteúdos, produtos ou serviços para ambientes multiplataforma. Como é imprescindível, a crise sanitária surge como um contexto atípico e de pano de fundo para algumas das discussões propostas.
PRIMARY ADENOCARCINOMA OF THE LACRIMAL GLAND: CASE REPORT
Authors:   Radiation Oncology Department, Oncology Hospital, Hassan II university Hospital. Fes, Morocco., Soussy Kaoutar , Ait Erraisse Mohamed ,   Radiation Oncology Department, Oncology Hospital, Hassan II university Hospital. Fes, Morocco., Ouazzani Habiba ,   Ophthalmology Department, Hassan II University Hospital, Fes, Morocco., Zarhaa Farhane Fatima ,   Radiation Oncology Department, Oncology Hospital, Hassan II university Hospital. Fes, Morocco., Bouhafa Touria ,   Radiation Oncology Department, Oncology Hospital, Hassan II university Hospital. Fes, Morocco.
Published: March 2022

A patient aged of 43-years-old presented a left exophthalmia, was diagnosed with adenocarcinoma of the lacrimal gland. Loco regional assessment in the CT and MRI showed a tumor of 3 cm diameter in the superolateral angle of the left orbit infiltrating the left lateral rectus muscle. He had exenteration of the left eye. Given the positive margins, adjuvant radiotherapy was indicated. The radiotherapy was delivered using intensity modulated radiation therapy (IMRT) technique in order to overcome anatomical complexity of the region, cover the tumor bed and preserve the organs at risk.
CAMBIOS HISTOPATOLOGICOS EN PACIENTES CON HERNIA DE PARED ABDOMINAL Y SU ASOCIACION CON COLAGENOSIS
Authors:   Departamento de Cirugia General, Centro Medico Naval, Ciudad de Mexico, Mexico., Angel Moreno Suarez Miguel , Alejandro Gomez Chavez Manuel ,   Departamento de Cirugia General, Centro Medico Naval, Ciudad de Mexico, Mexico.
Published: March 2022

Una hernia es recidivante cuando aparece una protuberancia nueva en donde se opero previamente. Del total de plastias en Mexico, 25% son cirugÃ­as por recidiva de hernias inguinales. Existen factores que influyen en la recidiva de hernia inguinales: Excesiva tension de sutura, elevaciones de la presion intraabdominal, defectos en el metabolismo de la colagena, comorbilidades, factores locales del sitio quirÃºrgico, tecnica quirÃºrgica y experiencia del cirujano. De un total de 39 pacientes se encontraron diferencias en el porcentaje de colagena en muestras de aponeurosis de lÃ­nea media con antecedente de hernia respectivamente (p=0.001). Por lo que, existen diferencias significativas en las variables de tipo hernia de pared, colagenosis, asÃ­ como en las caracterÃ­sticas macroscopicas de la aponeurosis. De igual manera se encontraron diferencias en el tipo de sexo, predominando el masculino, y una prevalencia de > 60 aÃ±os. Entre IMC y disminucion de colageno no se establecio una correlacion positiva. Objetivo: Evaluar y analizar los resultados obtenidos por microscopia optica de la estructura de las fibras de colageno en pacientes con y sin patologia herniaria. Material y metodos: Se realizoel estudio histopatologico de aponeurosis de linea mediaen pacientes con diagnostico de hernia de la pared abdominal, el grupo de comparacion seran pacientes intervenidos quirurgicamente sin evidencia o antecedente de defecto . Se realizoÌ el analisis descriptivo e inferencial con el fin de comparar si existian cambios en la cantidad de colageno en ambos grupos. Resultados: En pacientes con presencia de hernia de pared evidenciada clinicamente, el recambio de los colagenos de la matriz intesticial ( p 0.05) disminuyo en comparacion con los controles.c Conclusiones: Los pacientes que presentan una hernia de pared de cualquier localizacion concomitantemente presentara otra hernia de cualquier otra region de la economia P 0.036, por lo que se sugiere que en la practica diaria la busqueda intencionada de otro defecto y de ser posible realizar el mismo realizar la intervencion en el mismo tiempo quirurgico de esta manera disminuyendo los costos y riesgos anestesicos.
THE MAIN DIRECTIONS OF RELATIONS BETWEEN UZBEKISTAN AND THE UNITED NATIONS
Authors:   Basic Doctoral Student,Tashkent State University of Oriental Studies, Uzbekistan., Otabek Nizomiddinkhujayev
Published: March 2022

The article analyzes the role and tasks of the United Nations in supporting the development of civil society institutions in Uzbekistan, the large-scale socio-political, socio-economic, judicial, legal, democratic reforms and transformations carried out in the country.In Uzbekistan, human rights protection is seen as one of the priorities of interaction with the UN. At present, country has established a stable political system that meets modern criteria of democracy and human rights, the legislative, executive and judicial authorities of all levels are actively working. But most importantly, respect for the principles of the rule of law and human rights is being established in society.
INFLUENCE OF CEMENT DOSE ON THE DURABILITY OF STRUCTURES IN STABILIZED COMPRESSED EARTH BLOCKS
Authors:   Department of Civil Engineering, National Superior School of Engineers, University of Lome, TOGO., Banakinao Sinko , Drovou Soviwadan ,   Department of Mechanical Engineering, National Superior School of Engineers, University of Lome, TOGO., Attipou Kodjo ,   Department of Mechanical Engineering, National Superior School of Engineers, University of Lome, TOGO.
Published: March 2022

Structures in stabilized Compressed Earth Blocks (CEB), and more precisely the exterior walls (exposed to rainwater) or interior walls (exposed to spray water room, e.g.: bathroom) constructed with sand clay of class 2, suffer from decrepitude and crumbling, which are degradations due to environmental stresses. In order to solve this problem of degradations, it is necessary to find a minimum dosage level of cement that ensures the resistance to rupture and environmental stresses, in particular the aggression from rainwater and/or rise in moisture by capillarity, penetration by gravity, by suction or internal condensation. Two tests of durability have been conducted to simulate the two phenomena. These are a cyclic test of alternated wetting and drying to simulate the phenomenon of rise in moisture and a spray test to simulate the aggression from rainwater. The results of these tests show that a minimum dosage of 10% is sufficient to strengthen durably the walls against environmental stresses.
THE IMPORTANCE OF INTERPROFESSIONAL TEAMWORK WHENDEALING WITH CHILDREN WITH SPECIAL EDUCATIONAL NEEDSIN ROMANIA
Authors:   PhD Student At The Faculty of Psychology and Educational Sciences in Bucharest., Radu Anamaria PhD Student Petcu
Published: March 2022

Inclusive education of children in Romania and around the world is a priority. Governments are beginning to realize that a person with special integrated, independent educational needs reduces the costs that the whole nation would incur. I have witnessed the disappointment of the parents of children with SEN, and implicitly of these children, when it comes to the integrated educational system in Romania, a system that is not prepared to really help their children, on the contrary, it aggravates their deficiency. The difficult requirements of all the school programs, the overloaded curriculum, the large number of children enrolled in a class, very few specialists to support children, and teachers who feel helpless when facing so many requests.
DOES THE EDUCATIONAL DRAMA METHODS AND TECHNIQUES EXIST IN ISLAM AND USED BY THE PROPHET MUHAMMAD (PBUH)? AN EXPLORATORY STUDY
Authors:   Bsharat.Faculty of Major Language Studies, UniversitiSains Islam Malaysia, Malaysia, Bandar BaruNilai, Nilai, Negeri Sembilan., R.K. Tahani , A. Abed Baraa ,   College of Graduate Studies, Department of Media and Communication, Arab American University, Ramallah, West Bank, Palestine.
Published: March 2022

Michael Hart spent 28 years writing a book called The Hundred Greats and after he finished writing it, he announced in his lecture in London about the greatest personality in history, and the audience whistled at him and interrupted him with protest and screaming so that his speech would not be completed... saying: [The man stopped in a small village, which is Mecca. He said to the people in it: I am the Messenger of God to you... I came to perfect your morals. So he believed with him four. His wife, a friend, and two children! Now, after 1400 years, the number of Muslims has exceeded one and a half billion, and every day it is increasing. It cannot be a liar because no lie lives 1400 years. No one can ever deceive more than a billion and a half people. There is one more thing. Despite the passage of this long time, there are millions of Muslims who are ready to sacrifice themselves for the sake of a word that affects their Prophet. He is the greatest character in history(Hart,1978). furthermore, educational drama exists in Islam and our prophet Muhammad PBUH used the Drama and its techniques such as acting, Role-play, Mime, Simulations, practice, repeat things, and story-telling and all of these methods and techniques related to Drama.
PRIVATIZATION OF THE HEALTH SYSTEM
Authors: Levin Dvir
Published: March 2022

Foreword In this chapter we will discuss the privatization of the health system in Israel since the enactment of the National Health Insurance Law (hereinafter: Law) in 1995. As explained below, this law constitutes a nationalization of important parts of the health system. Therefore, when we consider the extent to which the health system is undergoing a process of privatization, it is important to distinguish between two questions: Have fields that were private before 1995 remained so? Has there been a setback in the scope of nationalization within the law and a greater role has been placed on the private sector?
WATER SAVING OF RICE CROP USING INNOVATIVE TECHNIQUE FOR SOIL MANAGEMENT, SWMR
Authors:   Irrigation and Drainage Unit, Soil Conservation and Water Resources, Dept. Desert Research Center, Cairo, Egypt., Elhagarey Mohamed
Published: March 2022

The trial was conducted in, 2019 and 2020 Kafr-El Sheikh Governorate, Egypt, Rice (Sakha 104) was cultivated under two methods, traditional method (WTF3) and modified innovative method in furrow bottoms, soil and water management for rice cultivation (SWMR). The cross section of furrows is such as a zigzag shape using a soil management and soil bed preparation (soil surface shape) using innovative machine to soil bed preparation to harvest irrigation water. Without any reduction of rice intensity, and rice transplants at 40 ÃƒÂƒÃ‚Â—40 cm in both of two cultivation methods. Besides, three treatments of nutrients (50, 75 and 100% of recommended doses and called WMF1, WMF2 and WMF3 respectively), irrigation system are traditional system for the first method and furrow irrigation systems for the modified innovative method, applied water amount and nutrients was measured, productivity parameters, economic and energy analysis. The results show that applied water in 2019 are 13104 and 6897 m3/ ha while in 2020 are 12510 and 6724 m3/ha, for the traditional and modified cultivation methods, Respectively. Rice yield in 2019 is 7589, 8282, 8987 and 8580 in 2020 is 7392, 8366, 8770 and 8376 kg/ha. For both of WMF1, WMF2, WMF3 and WTF3, respectively, finally, every parameters engaged with irrigation water is influenced according to the water foot print of rice is cut to half. SWMR technique can save about 20% of irrigation water will be saved in world.
GALLBLADDER PERFORATION: EXPERIENCE OF 35 CASES AT A TERTIARY CARE HOSPITAL
Authors:   Post Graduate, Department Of Surgery, GMC Srinagar., Javid Hafiz Sheema , Ah Awan Naseer ,   Professor Department Of Surgery, GMC Srinagar., Ahmad Parrey Manzoor ,   Post Graduate, Department Of Surgery, GMC Srinagar., Hussain Hela Aamir ,   Senior Resident, Department Of Surgery, GMC Srinagar.
Published: March 2022

Introduction: Gall bladder stone disease is one of the commonest hepatobiliary disease encountered in any general surgical outdoor worldwide especially in fertile females who are obese and in their 4th or 5th decade of life. One of the complications can be gallbladder perforation, although can be a sequel to acalcular cholecystitis. In India, incidence of Gall bladder perforation is estimated to be around 4%. There has been a marked increase in the incidence of the gallstone in the West during the past century. Material and Methods: The aim of our study was to highlight the Etiopathogenesis, Diagnosis, Management and Complications of gall bladder perforations. Results: In our study 35 patients were studied ageing between 25-80 years of age with a mean age of 54.3+14.53 years. Majority of our study patients i.e. 13 (37.1%) aged >60 years. Type 2 GB perforation was seen in 30 (85.7%) patients, followed by Type 1 in 3 (86% patients while as 2 (5.7%) patients were found to have Type 3 GB perforation. Percutaneous drainage of gall bladder was done in majority 30 (85.7%) patients. Conclusion: Type II gallbladder perforation is the most common type. Contrast- enhanced CT has an important role in diagnosing gallbladder perforation. Early suspicion, diagnosis, and appropriate management are of crucial importance for a better outcome in patients with gall bladder perforation.
LIVED EXPERIENCES OF SCIENCE TEACHERS OF PANGASINAN II IN THE NEW NORMAL EDUCATION: A PHENOMENOLOGICAL STUDY
Authors:   Mataasna Paaralang Juan C. Laya., S. Guillermo Allan , T. Manzano Angelo ,   Juan G. Macaraeg National High School.
Published: March 2022

The Covid-19 pandemic brought unprecedented challenges in the sector of Philippine education. The Department of Education Basic Education Learning Continuity Plan (BE-LCP) aims to ensure the continuity of learning thus, Pangasinan Division II implemented the Printed Modular Distance Learning (MDL) for the school year 2020-2021. The primary objective of this study is to understand the lived experiences of Science Teachers of Pangasinan Division II in the new normal setting of education. Using phenomenology, this study explored the challenges in adapting the new learning modality, the implementation of Most Essential Learning Competencies (MELCs), the production, distribution, and retrieval of self-learning modules (SLMs), the implementation of the interim guidelines in the grading system in the new normal education and the priority developmental plans and needs of Science teachers. From the data gathered through interview and analysis of the documents among twenty (20) Science teachers, it revealed that emerging themes capped into the acronym SURVIVORS which unfolds the Science teachers characteristics and experiences in the new face of education. The results showed that Science teachers are service-oriented, and the stakeholders showed unwavering support of stakeholders in the new learning modality. However, majority of the teachers exclaimed that distribution and retrieval of modules is the primary problem that arise from the different schools. Science teachers cope with these challenges through community partnerships and extending linkages that help them facilitate the distribution and retrieval of modules. In addition to that, Science teachers also acknowledged that printed modular learning should be shifted to blended learning as a modality in delivering education in the succeeding years. Integrating ICT through E-learning or online asynchronous learning could supplement the learners competencies alongside with the printed modules. Also, Science teachers have common priority development needs in terms of functional and core competencies. Lastly, it is notable that Science teachers should always be flexible and adaptive in their roles of as facilitators of education.
UTAUT VARIABLES TO INCREASE REUSE BEHAVIOR OF E-MONEY IN INDONESIA
Authors:   Pelita Harapan University, Surabaya Campus., C. Siahaya Janice , E.E. Napitupulu Priskilla ,   Pelita Harapan University, Surabaya Campus., Sugijanto Ken ,   Pelita Harapan University, Surabaya Campus.
Published: March 2022

Rapid advances in technology and information have changed almost the lifestyle of people in the world. Todays society tends to use and utilize technology in every way. In fact, recently the development of technology and information has encouraged the development of payment instruments into e-money. Indonesia is also one of the countries that supports the development of e-money, and now the development of e-money in Indonesia itself can be said to be growing rapidly. However, this certainly has an impact on the competition in the e-money industry, which is getting tougher every year. Therefore, it is important for the e-money industry to continue to increase actual usage, of course, in order to remain competitive in the midst of fierce competition in the e-money industry. The purpose of this study was to determine the effect of Performance Expectancy, Effort Expectance, Social Influence, Facilitating Condition, Hedonic Motivation, Habit, Intention to reuse and Reuse Behavior on gopay users in Surabaya. The benefit of this research is to be an input in knowing what factors influence Reuse Behavior. This research is a causal research using quantitative methods and processed with the help of a statistical program, namely SPSS version 22.0. Data was collected by distributing questionnaires using the snowball sampling technique to 120 respondents.Based on data analysis is that from seven proposed hypotheses, six hypotheses are supported and one hypothesis is rejected.
E-BANKING INTERNAL AND EXTERNAL STIMULI TO IMPROVE E-SATISFACTION AND E-LOYALTY M-BANKING IN INDONESIA
Authors:   Pelita Harapan University, Surabaya., a Ronald , b Amelia ,   Pelita Harapan University, Surabaya., Soedibyo Yolanda ,   Pelita Harapan University, Surabaya., Intan Kumala Cynthia ,   Pelita Harapan University, Surabaya., Juliani Leliga Felicia ,   Pelita Harapan University, Surabaya., Natalia Kartika ,   Pelita Harapan University, Surabaya.
Published: March 2022

Rapid advances in technology and information have changed Intensity of business competition in Indonesia currently increasing every day. The rapid development of technology and information has had a developmental impact in various fields, including in the field of payment systems in buying and selling transactions known as Mobile Banking or electric money or E-money. E-money is a non-cash payment facility that is widely applied in a number of countries in the world, including Indonesia.Jenius is Banking Reinvented full control in managing life and finances in a simpler, smarter, and safer way, from smartphone.This study aims to determine whether the factors ofPrivacy and Security, Apps Design, Customer Service to E-Banking LoyaltythroughE-Banking Satisfaction. In this study respondents collected were 200 user of Jenius in Surabaya according to the characteristics of respondents using snowball technique. Based on data analysis is that from four proposed hypotheses, all hypotheses are supported.
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): Current Therapies
and Future Approaches
Authors: Svačina Martin K.R. , Lehmann Helmar C.
Published: March 2022

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated polyradiculoneuropathy
leading to disability via inflammatory demyelination of peripheral nerves. Various therapeutic
approaches with different mechanisms of action are established for the treatment of CIDP. Of those, corticosteroids,
intravenous or subcutaneous immunoglobulin, or plasma exchange are established first-line therapies
as suggested by the recently revised EAN/PNS guidelines for the management of CIDP. In special cases,
immunosuppressants or rituximab may be used. Novel therapeutic approaches currently undergoing clinical
studies include molecules or monoclonal antibodies interacting with Fc receptors on immune cells to alleviate
immune-mediated neuronal damage. Despite various established therapies and the current development of novel
therapeutics, treatment of CIDP remains challenging due to an heterogeneous disease course and the lack of
surrogate parameters to predict the risk of clinical deterioration. This review summarizes established therapies
for CIDP and provides an outlook on future therapeutic approaches.
An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint
Authors: Amini Mohsen , Moghadam Ebrahim Saeedian , Mireskandari Katayoon , Abdel-Jalil Raid
Published: March 2022

Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to the importance of pyrrole structure in drug design and development, herein, we tried to conduct an extensive review of the bioactive pyrrole-based compounds reported recently. The bioactivity of pyrrole derivatives varies, so in the review, we categorized them based on their direct pharmacologic targets. Therefore, readers are able to find the variety of biological targets for pyrrole-containing compounds easily. This review explains around seventy different biologic targets for pyrrole-based derivatives, so it is helpful for medicinal chemists in the design and development of novel bioactive compounds for different diseases. This review presents an extensive, meaningful structure-activity relationship for each reported structure as much as possible. The review focuses on papers published between 2018 and 2020.
Multifunctional 99mTc-5-azacitidine Gold Nanoparticles: Formulation,
In Vitro Cytotoxicity, Radiosynthesis, and In Vivo Pharmacokinetic Study
Authors: Rashed Hassan M. , Sakr Tamer M. , Eldin Samar S. Ezz , Hassan Amira H. , Salem Heba F.
Published: March 2022

Background:

5-azacitidine is a very potent chemotherapeutic agent that suffers from certain limitation.

Objective:

This study aims to prepare gold nanoparticles as a new nano-formula of 5-azacitidine that can improve its bioavailability and decrease its side effects.

Methods:

5-azacytidine loaded GA-AuNPs were prepared and characterized by UV-Vis spectroscopy, infrared (IR) and transmission electronic microscope (TEM). This new platform was characterized in vitro by measuring its zeta potential, particle size, drug loading efficacy and its anti-proliferative effect on MCF-7 cell line was evaluated. In vivo biodistribution studies of 99mTc-5-aza solution and 99mTc-5-aza-gold nano formula were conducted in tumor bearing mice by different routes of administration (Intravenous and Intra-tumor).

Results:

5-Aza-GA-AuNPs formula was successfully prepared with optimum particle size of ≈34.66 nm, zeta potential of -14.4 mV and high entrapment efficiency. 99mTc-5-Aza-GA-AuNPs was efficient radiosynthesized (95.4%). Biodistribution studies showed high selective accumulation in tumor and low uptake in non-target organs in case of 5-Aza-GA-AuNPs formula than 99mTc-5-azacitidine solution.

Conclusion:

99mTc-5-Aza-GA-AuNPs had succeeded to improve the selectivity and uptake of 5-azacitidine in cancer. Moreover, 99mTc-5-Aza-GA-AuNPs could be used as a hopeful theranostic radiopharmaceutical preparation for cancer.
Melatonin As An Antioxidant Agent In Disease Prevention: A Biochemical Focus
Authors: Akhzari Morteza , Barazesh Mahdi , Jalili Sajad
Published: March 2022

In recent years, free radicals and oxidative stress are associated with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases. Confirming the role of oxidants in numerous pathological situations, including cancer, developing antioxidants as therapeutic platforms are needed. It has been well established that melatonin and its derived metabolites function as endogenous free-radical scavengers and broad-spectrum antioxidants. To achieve this function, melatonin can directly detoxify reactive oxygen and reactive nitrogen species and indirectly overexpress antioxidant enzymes while suppressing the activity of pro-oxidant enzymes. Many investigations have also confirmed the role of melatonin and its derivatives in different physiological processes and therapeutic functions, such as controlling the circadian rhythm and immune functions. This review aimed to focus on melatonin as a beneficial agent for the stimulation of antioxidant enzymes and inhibition of lipid peroxidation and to evaluate its contribution to protection against oxidative damages. In addition, the clinical application of melatonin in several diseases is discussed. Finally, the safety and efficacy of melatonin in clinical backgrounds are also reviewed.
Cryofibrinogenemia: What Rheumatologists Should Know
Authors: Santiago Mittermayer B. , Melo Bartira Souza
Published: March 2022

Cryofibrinogenemia refers to the presence of cryofibrinogen in plasma. This protein has the property of precipitating at lower temperatures. Cryofibrinogenemia is a rare disorder, clinically characterized by skin lesions, such as ulcers, necrosis, livedo reticularis, arthralgia, thrombosis, and limb ischemia. These features are most often observed in rheumatological practice and consist of differential diagnoses of antiphospholipid syndrome, primary vasculitis, thrombotic thrombocyto-penic purpura, and cryoglobulinemia. Classical histopathological findings include the presence of thrombi within the lumen of blood vessels of the skin without vasculitis. To date, there are no vali-dated classification criteria. Management includes corticosteroids, immunosuppressive therapy, an-ticoagulants, and fibrinolytic agents. This narrative review aims to make physicians, particularly rheumatologists, aware of the existence of this underdiagnosed condition. There are no epidemio-logical studies evaluating the prevalence of cryofibrinogenemia in different rheumatological disor-ders. Studies are also required to investigate if certain features of rheumatological diseases are relat-ed to the presence of cryofibrinogenemia.
Uterine Tumor Resembling Ovarian Sex Cord Tumors (UTROSCT): Two
Case Reports of the Rare Uterine Neoplasm with Literature Review
Authors: Guo Zhiqiang , Pang Li , Dai Yawen , Ren Fang , Peng Xu
Published: March 2022

Introduction:

Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare
neoplasms with unknown etiology. This type of tumor has low malignant potential and mostly manifests
as a benign clinical course.

Materials and Methods:

This article analyzes the case data, clinical manifestations, and histopathological
characteristics of two cases of UTROSCT, and reviews the relevant literature. The diagnosis of
UTROSCT is mainly based on histopathological examination. The histological characteristics of granulosa
and Sertoli cell tumours are similar to the ovary under the microscope. These cases' clinical and
radiological (MRI) findings have also been discussed.

Results:

The sex cord components are mixed in different proportions. The immunohistochemistry is
diverse and can express sex cord markers together with both epithelial and smooth muscle markers.
Both two cases revealed the signs of intratumoral cystic degeneration, intratumoral hemorrhage, and
necrosis under MRI. These MRI features were helpful to prompt UTROSCT, which is histologically
similar to granular cell tumors and is conducive to the differential diagnosis.

Conclusion:

The current recommended treatment is total hysterectomy, but its biological behavior is
not yet clear, and long-term follow-up is needed.
An Unusual Complication of Transarterial Chemoembolization of
Hepatocellular Carcinoma; Pseudoaneurysm: A Case Report
Authors: Atay Musa , Ozdemir Huseyin
Published: March 2022

Background:

Transarterial chemoembolization (TACE) is a globally recognised treatment
method for hepatic tumors, especially unresectable hepatocellular carcinoma (HCC). Although the
technique is relatively safe, it may cause serious complications, such as liver abscess, liver failure, and
non-target embolization. Here, the case of a rare complication of TACE is presented.

Case Presentation:

A-55-year-old male patient was referred to the interventional radiology department
for surgically unresectable HCC. CT scan showed a heterogeneously enhancing lesion with capsular
enhancement consistent with HCC. On MRI examination, a central necrotic part was seen within the
lesion, and TACE was performed. At the end of the TACE, a pseudoaneurysm of the hepatic artery
was detected, which was successfully embolized with pushable micro-coils.

Conclusion:

To the best of our knowledge, very few cases of pseudoaneurysm of the hepatic artery
have been described in the literature, and in those cases, the cause has been thought to be guidewire
manipulation. In contrast, in the current case, it was thought that it might occur due to central necrosis
and central perfusion insufficiency of the lesion. Pseudoaneurysm is a treatable condition with coil
embolization.
Comprehensive Performance Analysis of Soft Data Fusion Schemes under
SSDF Attacks in Cognitive Radio Networks
Authors: Bouzegag Younes , Djamal Teguig , Abdelmadjid Maali
Published: March 2022

Background:

Trust and security are the biggest challenges facing the Cooperative Spectrum
Sensing (CSS) process in Cognitive Radio Networks (CRNs). The Spectrum Sensing Data Falsification
(SSDF) attack is considered the biggest threat menacing CSS.

Methods:

This paper investigates the performance of different soft data combining rules such as Maximal
Ratio Combining (MRC), Square Law Selection (SLS), Square Law Combining (SLC), and Selection
Combining (SC), in the presence of Always Yes and Always No Malicious User (AYMU and
ANMU).

Results:

This comparative study aims to assess the impact of such malicious users on the reliability of
various soft data fusion schemes in terms of miss detection and false alarm probabilities. Furthermore,
computer simulations are performed to show that the soft data fusion scheme using MRC is the best in
the field of soft data computing.

Conclusion:

ANMU has a slight impact on CSS. Yet, AYMU affects the cooperative detection performance.
Cooperative Spectrum Sensing under SISO and MIMO Environment for
Cognitive Radio Networks
Authors: Bani Kavita , Kulkarni Vaishali
Published: March 2022

Background:

Increasing demand for wireless devices leads to the efficient use of spectrum
resources. Despite the limited availability of spectrum resources, all licensed users do not utilize their
spectrum all the time.

Objective:

Cognitive Radio (CR) is used to detect free channels in the available spectrum resources
and access them dynamically without interfering with licensed users. Various spectrum sensing (SS)
techniques are available to sense the spectrum of licensed users.

Methods:

The spectrum sensing technique, energy detector (ED), is analysed under a Rayleigh fading
channel. Further, Single Input Single Output (SISO) and Multiple Input Multiple Output (MIMO)
channel models are developed in the consumer environment. The ED technique is further analysed
with cooperative spectrum sensing (CSS) to overcome detection problems for a single CR user.

Results:

The ED achieves a probability of detection (PD) of 0.9 and a probability of false alarm (PFA)
of 0.1 at the lowest SNR of −20 dB, which is the requirement for a standard IEEE 802.22 Wireless
Regional Area Network (WRAN).

Conclusion:

Various receiver operating characteristics are determined by conducting practical simulations
and theoretical calculations for each SISO and MIMO channel model with and without the CSS
scenario to achieve the target PD and PFA .
Correlation of Personality Traits and Academic Performance of
Jordanian Medical Students: A Cross-Sectional Study
Authors: Miles Katherine , El-Sheikh Yasar A. , Humaidat Eman , Banat Yazan , Ibrahim Nada , Suheimat Ghayd
Published: March 2022

Background:

Differences in personality may have an impact on academic performance,
however, academic assessments aim to measure knowledge, skills, and behavior
domains rather than personality.

Objectives:

To investigate the relation between personality traits and academic performance
of medical students and evaluate if correlations between personality traits and examination
scores are affected by gender or stage of study (pre-clinical versus clinical).

Methods:

This cross-sectional study used an online questionnaire to identify Big Five Model
personality traits of medical students at the Hashemite University, Jordan. A stratified
sampling technique, according to the stage of study and gender, resulted in a sample
of 307 medical students who completed the questionnaire. Grade Point Average (GPA)
scores, as a measure of academic performance, were retrieved from the University database
for each participant and data was analysed using SPSS 16.0. The correlation between personality
traits and GPA score was investigated using Pearson coefficient. Two-way
ANOVA testing investigated the effect of gender and stage of study and the interaction of
these factors with personality traits on GPA.

Results:

Only conscientiousness had a significant positive correlation with GPA (r = .231, p
< .001). Two-way ANOVA showed only conscientiousness had a statistically significant
effect on GPA (F (1, n=307) = 10.353, p = .001). Investigating the interaction between gender,
stage of study and personality traits on GPA, showed only a statistically significant interaction
effect between stage of study and openness on GPA (F (1, n=307) = 10.297, p
=.001).

Conclutions:

Overall, personality traits did not unduly influence the assessment procedures,
except a positive correlation of conscientiousness with academic performance and interaction
between openness and stage of study with academic performance. These findings, from
a developing country, advance our understanding of correlations between personality traits
and academic performance and may inform the development of equitable assessments in
similar contexts worldwide.
THE INFLUENCE OF TYPES AND ACT OF CHILDBIRTH ON THE RISKS OF POST PARTUM DEPRESSION
Authors:   Akbid Keris Husada Jakarta, Wulandari Aliesya , Nafi'ati Dini ,   SMF Psikiatri RSUD Dr. Saiful Anwar Malang
Published: March 2022

Depression that occurs postpartum is known as postpartum depression. In general, there is a 10-20% chance of developing postpartum depression in postpartum mothers. The incidence of postpartum depression in Indonesia ranges from 50-70% in postpartum mothers. Postpartum depression is a mood disorder that occurs after childbirth and reflects the psychological dysregulation that is a sign of major depression symptoms. There are several studies that prove that the occurrence of postpartum depression is often associated with side effects experienced by mothers during pregnancy, childbirth, or experiences of mothers with babies. Regarding obstetric causative factors, medical action is one of the factors that influence the psychological adaptation of postpartum mothers. The type of delivery affects the risk of postpartum depression due to the unpleasant experiences of the mother during childbirth. In the type of normal delivery, there are several factors that increase the risk of postpartum depression, such as prolonged labor, pain during labor, labor with device assistance and interventions in labor. In addition, the type of cesarean section delivery is a strong predisposing factor for the occurrence of postpartum depression childbirth with tool-assisted measures and interventions in childbirth. In addition, the type of cesarean section delivery is a strong predisposing factor for the occurrence of postpartum depression childbirth with tool-assisted measures and interventions in childbirth. In addition, the type of cesarean section delivery is a strong predisposing factor for the occurrence of postpartum depression. Keywords: postpartum depression, mother, delivery.
HALLUCINATION IN PATIENTS WITH BORDERLINE PERSONALITY DISORDER
Authors:   Medical Student of Medical Faculty University of Brawijaya, Malang, Savero Nico , Aji Aulia ,   Medical Student of Medical Faculty Universitas of Brawijaya, Malang, Alim Avicenna ,   Medical Student of Medical Faculty Universitas of Brawijaya, Malang, Suryananda I ,   Medical Student of Medical Faculty Universitas of Brawijaya, Malang, Pradibdo Ruth ,   Medical Student of Medical Faculty Universitas of Brawijaya, Malang, Hapsari Happy ,   Psychiatry Department RSUD Dr. Saiful Anwar Malang, Yudhantara Dearisa ,   Medical Faculty University of Brawijaya, Malang, Indonesia
Published: March 2022

In modern practice, hallucinations found in patients with borderline personality disorder (BPD) are often identified as ‘pseudohallucinations’ to state the suspicion that they do not qualify as true hallucinations. In the interest of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for BPD, it is stated that during times of tremendous stress, transient ideation of paranoid or dissociative symptoms may occur. BPD is defined as a mental health disorder with remarkable impulsivity, instability of mood and interpersonal relationships, along with suicidal behavior that can complicate medical treatment. It is crucial to identify this diagnosis to plan for further treatment. The existence and severity of hallucinations in BPD patients are closely related to posttraumatic stress disorder (PTSD), prior childhood adversities, as well as current adult life stressor. Auditory verbal hallucinations (AVH) were reported to be the most commonly observed types of hallucinations in patients with BPD. Similarities of the AVH characteristics between BPD patients and those with schizophrenia make it hard to diagnose and manage the hallucinations in BPD patients. Pharmacological management including both typical and atypical antipsychotic drugs may be beneficial in order to treat hallucinations in these patients, however, low-dose antipsychotics are preferred due to its adverse reaction. Psychotherapy such as cognitive behavior therapy (CBT) and non-invasive brain stimulation techniques may be helpful as well. Questioning patient’s psychotic symptoms in an untrue or “made-up” form is rarely advantageous and may leads to undesired therapeutic alliance dismissal. Keywords: hallucination, borderline personality disorder, depression.
THE EFFECT OF PERINEAL LACERATIONS IN DEVELOPMENT OP POSTPARTUM DEPRESSION Ni Putu Yunita Sri Lestari1; Ratri Istiqomah2
Authors:   S2 Kebidanan Medical Faculty University of Brawijaya, Lestari Ni , Istiqomah Ratri ,   Psychiatry Department RSUD Dr. Saiful Anwar Malang
Published: March 2022

Spontaneous vaginal deliveries allows perineal lacerations. The level of resistance of a person to perineal lacerations varies widely. The risk of developing postpartum depression is experienced by different groups of women. In the early months after delivery, depression is the most common morbidity in postpartum women. The presence of perineal lacerations can be a factor in the development of postpartum depression. Stress and anxiety disorders can be caused by the occurrence of grade 3 and 4 perineal lacerations. This study looked at the potential effect of perineal laceration on the incidence of postpartum depression in women with vaginal delivery. This systematic review used study research that related to postpartum depression and perineal lacerations. Articles that are relevant are searched for by the author on Google Scholar, ScienceDirect, and Pubmed from the last 5 years (2015-2020). By 5 of the 77 studies were discussed in the review. The studies were conducted in United States, Taiwan, France, Brazil, and Sweden, total 4.966 women were included. Three of five studies showing that the presence of perineal lacerations increases the incidence of postpartum depression but along with the development, two research from the last 2 years, perineal lacerations did not increase risk of postpartum depression. However, severe perineal lacerations increase risk of postpartum depression among women with low resilience with 3rd- 4th degree of perineal laceration support development of postnatal depression in women. Keywords: perineal, lacerations, depression, postpartum.
COPING STRATEGY IN MOTHER WITH POST PARTUM BLUES EXPERIENCE IN KEDIRI : A CASE REPORT
Authors:   Institut Ilmu Kesehatan Bhakti Wiyata Kediri, Andarini Anna , Ulya Zuhrotun ,   Psychiatry Department Medical Faculty University of Brawijaya
Published: March 2022

The postpartum blues occurs when a mother fails to accept her condition caused by pregnancy, pregnancy, childbirth and post partum. This research is very important because postpartum blues which is known as a form of mild depression can develop into postpartum depression if not treated properly. This study aims to explore coping strategies for postpartum blues sufferers by using a qualitative research method with a case study method. Two participants who were selected by purposive sampling technique, who experienced the postpartum blues were obtained from the city of Kediri. Methods Data collection was carried out through interviews (in-depth interviews), field notes, and input from The Edinburgh Postnatal Depression Scale (EPDS). The results of this study indicate that the coping used in mothers who experience post partum blues uses problem focused coping, but the participants have also used emotional focused coping. The use of this coping variation does not indicate that the strategy taken is decided without any consideration of problem solving. There are variations in the use of coping strategies because coping strategies do not have to end in solving the problem at once. This problem makes the participant's condition better than before. The participants feel calmer in dealing with every problem, are confident, and will stimulate the participants to seek more knowledge and be able to provide support to anyone, especially for mothers who experience post partum blues. Keywords: coping strategy, baby blues, partum.
MASS THERAPEUTIC EDUCATION FOR MONITORING SUICIDAL BEHAVIOR IN COMMUNITY
Authors:   Medical Student of Medical Faculty University of Brawijaya, Malang, Sofyan Fadhillah
Published: March 2022

Suicide is a worrying problem in Indonesia because of increase in case reported. There has been an increase in suicide rates both globally and in Indonesia. The negative stigma, lack of education, and lack of understanding of the role of the community make it difficult to reduce the number of suicides. This study aims to discuss mass therapeutic education for monitoring suicidal behavior in community. Researchers used 15 journals and literature that discuss the impact and vulnerability of distance learning on students' mental health conditions. The role of society in reducing the suicide rate is very much needed. The community can help make early detection of suicide. Society can help prevent suicidal ideas from arising in those around them. The public can provide information to the authorities and give advice for suicide perpetrators to visit a health center. The role of the community can be integrated in a structured and neat system that can make suicide prevention efforts became optimal. Keywords: suicidal, community, education.
Voice-Enabled Intelligent Virtual Agents for People With Amnesia: Systematic Review
Authors: Boumans Roel , van de Sande Yana , Thill Serge , Bosse Tibor
Published: March 2022

Background

Older adults often have increasing memory problems (amnesia), and approximately 50 million people worldwide have dementia. This syndrome gradually affects a patient over a period of 10-20 years. Intelligent virtual agents may support people with amnesia.

Objective

This study aims to identify state-of-the-art experimental studies with virtual agents on a screen capable of verbal dialogues with a target group of older adults with amnesia.

Methods

We conducted a systematic search of PubMed, SCOPUS, Microsoft Academic, Google Scholar, Web of Science, and CrossRef on virtual agent and amnesia on papers that describe such experiments. Search criteria were (Virtual Agent OR Virtual Assistant OR Virtual Human OR Conversational Agent OR Virtual Coach OR Chatbot) AND (Amnesia OR Dementia OR Alzheimer OR Mild Cognitive Impairment). Risk of bias was evaluated using the QualSyst tool (University of Alberta), which scores 14 study quality items. Eligible studies are reported in a table including country, study design type, target sample size, controls, study aims, experiment population, intervention details, results, and an image of the agent.

Results

A total of 8 studies was included in this meta-analysis. The average number of participants in the studies was 20 (SD 12). The verbal interactions were generally short. The usability was generally reported to be positive. The human utterance was seen in 7 (88%) out of 8 studies based on short words or phrases that were predefined in the agent’s speech recognition algorithm. The average study quality score was 0.69 (SD 0.08) on a scale of 0 to 1.

Conclusions

The number of experimental studies on talking about virtual agents that support people with memory problems is still small. The details on the verbal interaction are limited, which makes it difficult to assess the quality of the interaction and the possible effects of confounding parameters. In addition, the derivation of the aggregated data was difficult. Further research with extended and prolonged dialogues is required.