bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding Corrosion Morphology of Duplex Stainless Steel Wire in Chloride Electrolyte
Authors: Örnek Cem , Davut Kemal , Kocabaş Mustafa , Bayatlı Aleyna , Ürgen Mustafa
Published: July 2021

The corrosion morphology in grade 2205 duplex stainless steel wire was studied to understand the nature of pitting and the causes of the ferrite phase’s selective corrosion in acidic (pH 3) NaCl solutions at 60 °C. It is shown that the corrosion mechanism is always pitting, which either manifests lacy cover perforation or densely arrayed selective cavities developing selectively on the ferrite phase. Pits with a lacy metal cover form in concentrated chloride solutions, whereas the ferrite phase’s selective corrosion develops in diluted electrolytes, showing dependency on the chloride-ion concentration. The pit perforation is probabilistic and occurs on both austenite and ferrite grains. The lacy metal covers collapse in concentrated solutions but remain intact in diluted electrolytes. The collapse of the lacy metal cover happens due to hydrogen embrittlement. Pit evolution is deterministic and occurs selectively in the ferrite phase in light chloride solutions.
Comparison of Phase Characteristics and Residual Stresses in Ti-6Al-4V Alloy Manufactured by Laser Powder Bed Fusion (L-PBF) and Electron Beam Powder Bed Fusion (EB-PBF) Techniques
Authors: Takase Aya , Ishimoto Takuya , Morita Naotaka , Ikeo Naoko , Nakano Takayoshi
Published: July 2021

Ti-6Al-4V alloy fabricated by laser powder bed fusion (L-PBF) and electron beam powder bed fusion (EB-PBF) techniques have been studied for applications ranging from medicine to aviation. The fabrication technique is often selected based on the part size and fabrication speed, while less attention is paid to the differences in the physicochemical properties. Especially, the relationship between the evolution of α, α’, and β phases in as-grown parts and the fabrication techniques is unclear. This work systematically and quantitatively investigates how L-PBF and EB-PBF and their process parameters affect the phase evolution of Ti-6Al-4V and residual stresses in the final parts. This is the first report demonstrating the correlations among measured parameters, indicating the lattice strain reduces, and c/a increases, shifting from an α’ to α+β or α structure as the crystallite size of the α or α’ phase increases. The experimental results combined with heat-transfer simulation indicate the cooling rate near the β transus temperature dictates the resulting phase characteristics, whereas the residual stress depends on the cooling rate immediately below the solidification temperature. This study provides new insights into the previously unknown differences in the α, α’, and β phase evolution between L-PBF and EB-PBF and their process parameters.
Experimental Investigation of Double-End Pumped Tm, Ho: GdVO4 Laser at Cryogenic Temperature
Authors: Du Yanqiu , Dai Tongyu , Sun Hui , Kang Hui , Xia Hongyang , Tian Jiaqi , Chen Xia , Yao Baoquan
Published: July 2021

We describe comparatively cryogenically cooled Tm, Ho: GdVO4 lasers with an emission wavelength of 2.05 μm under continuous wave and pulse operating mode. By varying the transmittance of output couplers to be 0.40 for a continuous wave laser, the maximum output power of 7.4 W was generated with a slope efficiency of 43.3% when the absorbed pump power was increased to 18.7 W. For passively Q-switched lasers, the output characteristics were researched through altering pump mode radius. When the pump mode radius focused into the Tm, Ho: GdVO4 center equaled near 600 μm, the peak power was increased to be the maximum value of 9.9 kW at the absorbed pump power of 11.8 W. The pulse energy of 0.39 mJ was achieved at the same absorbed pump power with repetition of 5.7 kHz.
Citizens, Scientists, and Enablers: A Tripartite Model for Citizen Science Projects
Authors: Salmon Rhian A. , Rammell Samuel , Emeny Myfanwy T. , Hartley Stephen
Published: July 2021

In this paper, we focus on different roles in citizen science projects, and their respective relationships. We propose a tripartite model that recognises not only citizens and scientists, but also an important third role, which we call the ‘enabler’. In doing so, we acknowledge that additional expertise and skillsets are often present in citizen science projects, but are frequently overlooked in associated literature. We interrogate this model by applying it to three case studies and explore how the success and sustainability of a citizen science project requires all roles to be acknowledged and interacting appropriately. In this era of ‘wicked problems’, the nature of science and science communication has become more complex. In order to address critical emerging issues, a greater number of stakeholders are engaging in multi-party partnerships and research is becoming increasingly interdisciplinary. Within this context, explicitly acknowledging the role and motivations of everyone involved can provide a framework for enhanced project transparency, delivery, evaluation and impact. By adapting our understanding of citizen science to better recognise the complexity of the organisational systems within which they operate, we propose an opportunity to strengthen the collaborative delivery of both valuable scientific research and public engagement.
Evaluation of Melanocyte Loss in Mycosis Fungoides Using SOX10 Immunohistochemistry
Authors: Barron Cynthia Reyes , Smoller Bruce R.
Published: July 2021

Mycosis fungoides (MF) is a subtype of primary cutaneous T-cell lymphoma (CTCL) with an indolent course that rarely progresses. Histologically, the lesions display a superficial lymphocytic infiltrate with epidermotropism of neoplastic T-cells. Hypopigmented MF is a rare variant that presents with hypopigmented lesions and is more likely to affect young patients. The etiology of the hypopigmentation is unclear. The aim of this study was to assess melanocyte loss in MF through immunohistochemistry (IHC) with SOX10. Twenty cases were evaluated, including seven of the hypopigmented subtype. The neoplastic epidermotropic infiltrate consisted predominantly of CD4+ T-cells in 65% of cases; CD8+ T-cells were present in moderate to abundant numbers in most cases. SOX10 IHC showed a decrease or focal complete loss of melanocytes in 50% of the cases. The predominant neoplastic cell type (CD4+/CD8+), age, race, gender, histologic features, and reported clinical pigmentation of the lesions were not predictive of melanocyte loss. A significant loss of melanocytes was observed in 43% of hypopigmented cases and 54% of conventional cases. Additional studies will increase our understanding of the relationship between observed pigmentation and the loss of melanocytes in MF.
Sentinel Lymph Node Biopsy in Early Stages of Oral Squamous Cell Carcinoma Using the Receptor-Targeted Radiotracer 99mTc-Tilmanocept
Authors: Doll Christian , Steffen Claudius , Amthauer Holger , Thieme Nadine , Elgeti Thomas , Huang Kai , Kreutzer Kilian , Koerdt Steffen , Heiland Max , Beck-Broichsitter Benedicta
Published: July 2021

Neck management in patients with early-stage, clinically node-negative oral squamous cell carcinoma (OSCC) remains a matter of discussion. Sentinel lymph node biopsy (SLNB) represents a treatment alternative to avoid elective neck dissection (END) in this cohort and different protocols and tracers exist. Here we present the clinical outcome of SLNB using 99mTc-tilmanocept in a two-day protocol in patients suffering from early-stage OSCC. A total of 13 patients (males: 6; females: 7; mean age: 65.7 years, ranging from 47 to 89 years) were included in this study. Most of the patients suffered from an OSCC of the floor of mouth (n = 6), followed by tongue (n = 5) and upper alveolar crest/hard palate (n = 2). Sentinel lymph nodes (SLNs) were successfully identified in all cases (range: 1–7). The average length of hospital stay was 4.7 days (range: 3–8 days) and mean duration of surgical intervention was 121 min (range: 74–233 min). One patient who suffered from an OSCC of the tongue was sentinel lymph node positive (SLN+). The mean follow-up for all sentinel lymph node negative (SLN-) patients (n = 12) was 20.3 months (range: 10–28 months). No local or nodal recurrences were observed within the observation period. In our patient cohort, SLNB using 99mTc-tilmanocept in a two-day protocol proved to be a reliable and safe staging method for patients suffering from early-stage, clinically node-negative OSCC. These results and their possible superiority to colloid tracers have to be confirmed in a prospective randomized controlled study.
Development of Multi-Quadrotor Simulator Based on Real-Time Hypervisor Systems
Authors: Fathoni Muhammad Faris , Lee Seonah , Kim Yoonsoo , Kim Ki-Il , Kim Kyong Hoon
Published: July 2021

Today, simulator technology has been widely used as an important part of quadrotor development such as validation and testing. A good quadrotor simulator can simulate the quadrotor system as closely as possible to the real one. Therefore, in case of multi-quadrotor simulator, the simulator should not only can simulate a multi-quadrotor system, but also every quadrotor should be able to leverage their own resources. To solve this issues, in this paper, we present a hypervisor-based multi-quadrotor simulator. We used RT-Xen as hypervisor, a real-time Xen hypervisor. To ensure every quadrotor runs in real-time manner, we implemented quadrotor simulator in Litmus-RT which is a real-time extension of Linux. In this paper, we conducted some testing and performance evaluation for particular cases on our multi-quadrotor simulator: step-input responses, computation time, and response times. Based on the performance evaluation, our hypervisor-based multi-quadrotor simulator environment is proven to meet the real-time requirements. The results show that three important tasks in quadrotor system: Stability Controllability Augmented System (SCAS), Equation of Motion (EOM), and waypoint following task, are finished before their deadlines; in fact, 20 ms, 10 ms, and 40 ms before the deadlines for SCAS, EOM, and waypoint following, respectively.
Hierarchical Temporal Memory Theory Approach to Stock Market Time Series Forecasting
Authors: Sousa Regina , Lima Tiago , Abelha António , Machado José
Published: July 2021

Over the years, and with the emergence of various technological innovations, the relevance of automatic learning methods has increased exponentially, and they now play a key role in society. More specifically, Deep Learning (DL), with the ability to recognize audio, image, and time series predictions, has helped to solve various types of problems. This paper aims to introduce a new theory, Hierarchical Temporal Memory (HTM), that applies to stock market prediction. HTM is based on the biological functions of the brain as well as its learning mechanism. The results are of significant relevance and show a low percentage of errors in the predictions made over time. It can be noted that the learning curve of the algorithm is fast, identifying trends in the stock market for all seven data universes using the same network. Although the algorithm suffered at the time a pandemic was declared, it was able to adapt and return to good predictions. HTM proved to be a good continuous learning method for predicting time series datasets.
Classifier Performance Evaluation for Lightweight IDS Using Fog Computing in IoT Security
Authors: Khater Belal Sudqi , Abdul Wahab Ainuddin Wahid , Idris Mohd Yamani Idna , Hussain Mohammed Abdulla , Ibrahim Ashraf Ahmed , Amin Mohammad Arif , Shehadeh Hisham A.
Published: July 2021

In this article, a Host-Based Intrusion Detection System (HIDS) using a Modified Vector Space Representation (MVSR) N-gram and Multilayer Perceptron (MLP) model for securing the Internet of Things (IoT), based on lightweight techniques and using Fog Computing devices, is proposed. The Australian Defence Force Academy Linux Dataset (ADFA-LD), which contains exploits and attacks on various applications, is employed for the analysis. The proposed method is divided into the feature extraction stage, the feature selection stage, and classification modeling. To maintain the lightweight criteria, the feature extraction stage considers a combination of 1-gram and 2-gram for the system call encoding. In addition, a Sparse Matrix is used to reduce the space by keeping only the weight of the features that appear in the trace, thus ignoring the zero weights. Subsequently, Linear Correlation Coefficient (LCC) is utilized to compensate for any missing N-gram in the test data. In the feature selection stage, the Mutual Information (MI) method and Principle Component Analysis (PCA) are utilized and then compared to reduce the number of input features. Following the feature selection stage, the modeling and performance evaluation of various Machine Learning classifiers are conducted using a Raspberry Pi IoT device. Further analysis of the effect of MLP parameters, such as the number of nodes, number of features, activation, solver, and regularization parameters, is also conducted. From the simulation, it can be seen that different parameters affect the accuracy and lightweight evaluation. By using a single hidden layer and four nodes, the proposed method with MI can achieve 96% accuracy, 97% recall, 96% F1-Measure, 5% False Positive Rate (FPR), highest curve of Receiver Operating Characteristic (ROC), and 96% Area Under the Curve (AUC). It also achieved low CPU time usage of 4.404 (ms) milliseconds and low energy consumption of 8.809 (mj) millijoules.
Defect Index of Timberwork in House, Korea
Authors: Park Junmo , Seo Deokseok
Published: July 2021

Wood is a material that is familiar to humans and environment-friendly, and it is used widely as a building material. However, as the dispute over housing defects have increased in Korea, various defects have occurred in timberwork and have become disputes. Notwithstanding, efforts to analyze defects in timberwork systematically to reasonably solve the problem are lacking. In this study, defects in timberwork from housing complexes in Korea were standardized, and critical defects were selected to suggest a method as a management standard. The standard for defects includes time, types of facility work, location and subject, and defect phenomenon. The defect time is categorized into before handover and after handover, whereas facility work is divided into woodwork, door and window work, finishing work, and miscellaneous work. Location and subject are categorized into 13 areas, such as ceiling, floor, and door, and phenomena concerned are of 14 types, including faults and no installation. Therefore, the standardized defect items according to such criteria are classified into a total of 63 types. Ten defect items, whose numbers of defect occurrences per defect and defect repair cost ratio above the average, were selected, including discoloration and breakage of the wooden floor. The repair cost ratio of these defect items accounted for 85.62% of the total repair costs. On the contrary, the repair cost for the defects from the timber work outlined in the Construction Appraisal Practice, a representative defect standard in Korea, was 54.54% of the total. Meanwhile, according to the Defect Judgment Standard, the defect repair cost attributed 45.54% of the total. Therefore, since the 10 defect items proposed in this study can explain the defects in the timberwork compared with other standards, it would be reasonable to designate these 10 defect items as essential defects.
Obtaining Antioxidants and Natural Preservatives from Food By-Products through Fermentation: A Review
Authors: Martí-Quijal Francisco J. , Khubber Sucheta , Remize Fabienne , Tomasevic Igor , Roselló-Soto Elena , Barba Francisco J.
Published: July 2021

Industrial food waste has potential for generating income from high-added-value compounds through fermentation. Solid-state fermentation is promising to obtain a high yield of bioactive compounds while requiring less water for the microorganism’s growth. A number of scientific studies evinced an increase in flavonoids or phenolics from fruit or vegetable waste and bioactive peptides from cereal processing residues and whey, a major waste of the dairy industry. Livestock, fish, or shellfish processing by-products (skin, viscera, fish scales, seabass colon, shrimp waste) also has the possibility of generating antioxidant peptides, hydrolysates, or compounds through fermentation. These bioactive compounds (phenolics, flavonoids, or antioxidant peptides) resulting from bacterial or fungal fermentation are also capable of inhibiting the growth of commonly occurring food spoilage fungi and can be used as natural preservatives. Despite the significant release or enhancement of antioxidant compounds through by-products fermentation, the surface areas of large-scale bioreactors and flow patterns act as constraints in designing a scale-up process for improved efficiency. An in-process purification method can also be the most significant contributing factor for raising the overall cost. Therefore, future research in modelling scale-up design can contribute towards mitigating the discard of high-added-value generating residues. Therefore, in this review, the current knowledge on the use of fermentation to obtain bioactive compounds from food by-products, emphasizing their use as natural preservatives, was evaluated.
Improving the Utilization of Isomaltose and Panose by Lager Yeast Saccharomyces pastorianus
Authors: Porcayo Loza Javier , Chailyan Anna , Forster Jochen , Katz Michael , Mortensen Uffe Hasbro , Garcia Sanchez Rosa
Published: July 2021

Approximately 25% of all carbohydrates in industrial worts are poorly, if at all, fermented by brewing yeast. This includes dextrins, β-glucans, arabinose, xylose, disaccharides such as isomaltose, nigerose, kojibiose, and trisaccharides such as panose and isopanose. As the efficient utilization of carbohydrates during the wort’s fermentation impacts the alcohol yield and the organoleptic traits of the product, developing brewing strains with enhanced abilities to ferment subsets of these sugars is highly desirable. In this study, we developed Saccharomyces pastorianus laboratory yeast strains with a superior capacity to grow on isomaltose and panose. First, we designed a plasmid toolbox for the stable integration of genes into lager strains. Next, we used the toolbox to elevate the levels of the α-glucoside transporter Agt1 and the major isomaltase Ima1. This was achieved by integrating synthetic AGT1 and IMA1 genes under the control of strong constitutive promoters into defined genomic sites. As a result, strains carrying both genes showed a superior capacity to grow on panose and isomaltose, indicating that Ima1 and Agt1 act in synergy to consume these sugars. Our study suggests that non-GMO strategies aiming to develop strains with improved isomaltose and panose utilization could include identifying strains that overexpress AGT1 and IMA1.
In Vitro Fermentation Characteristics and Methane Mitigation Responded to Flavonoid Extract Levels from Alternanthera sissoo and Dietary Ratios
Authors: Sommai Sukruthai , Cherdthong Anusorn , Suntara Chanon , So Sarong , Wanapat Metha , Polyorach Sineenart
Published: July 2021

Two experiments were conducted under this study: Experiment 1 was to study production yield, chemical composition, and in vitro degradability of Brazilian spinach (Alternanthera sissoo; BS) leaf and leaf + leaf-stalk at various maturity ages of 15, 30, 45, and 60 days after plantation and regrowth and Experiment 2 was to evaluate the effect of flavonoid extract from BS leaf and leaf + leaf-stalk and dietary ratios on ruminal gas production, fermentation characteristics, and in vitro degradability. Experiment 1 showed that maturity ages after planting and regrowth increased, the yield significantly increased. Increasing maturity ages significantly (p < 0.05) increased neutral detergent fiber and acid detergent fiber content and decreased crude protein content, total flavonoid (TF) content, and degradability for both leaf and leaf + leaf-stalk. Maturity ages from 15 to 30 days after plantation and regrowth resulted (p < 0.05) the highest TF content and degradability for both leaf and leaf + leaf-stalk. Thus, BS leaf and leaf + leaf-stalk samples from 15 to 30 days of age were used for flavonoid extraction and used in the Experiment 2. Experiment 2 was conducted according to a 3 × 5 factorial experiment. Three roughage to concentrate (R:C) ratios at 50:50, 40:60, and 30:70 were used, and five levels of flavonoid extract (FE) at 0, 10, 20, 30, and 40 mg of substrate dry matter (DM) were supplemented. Experiment 2 showed that R:C ratio and FE had an interaction effect only on acetate to propionate ratio. Varying R:C ratios significantly increased (p < 0.05) in vitro DM degradability, total volatile fatty acids (VFA), and propionate (C3) concentration. FE supplementation linearly (p < 0.05) increased total VFA and C3 concentration and decreased methane production and protozoal population. This study could conclude that FE from BS could effectively modulate ruminal fermentation and decrease methane production. However, in vivo study needs to elucidate in order to validate the present results.
Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
Authors: Cabello-Olmo Miriam , Araña Miriam , Urtasun Raquel , Encio Ignacio J. , Barajas Miguel
Published: July 2021

In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory techniques have allowed the identification and characterisation of new biologically active molecules, referred to as “postbiotics”. Postbiotics are defined as functional bioactive compounds obtained from food-grade microorganisms that confer health benefits when administered in adequate amounts. They include cell structures, secreted molecules or metabolic by-products, and inanimate microorganisms. This heterogeneous group of molecules presents a broad range of mechanisms and may exhibit some advantages over traditional “biotics” such as probiotics and prebiotics. Owing to the growing incidence of DM worldwide and the implications of the microbiota in the disease progression, postbiotics appear to be good candidates as novel therapeutic targets. In the present review, we summarise the current knowledge about postbiotic compounds and their potential application in diabetes management. Additionally, we envision future perspectives on this topic. In summary, the results indicate that postbiotics hold promise as a potential novel therapeutic strategy for DM.
A Note on Numerical Representations of Nested System of Strict Partial Orders
Authors: Qin Dan
Published: July 2021

This note provides two numerical representations of a nested system of strict partial orders. The first representation is based on utility and threshold functions. We generalize the threshold representation of menu-dependent preferences by allowing the threshold to depend not only on the menu but also on the pair of alternatives under comparison. The threshold function can be interpreted as the distance between alternatives. The second representation is based on the aggregation of multi-dimensional preference. This representation describes a decision-making procedure where multiple criteria are gradually aggregated into an overall assessment.
Astrophysical Neutrinos in Testing Lorentz Symmetry
Authors: Roberts Ágnes
Published: July 2021

An overview of searches related to neutrinos of astronomical and astrophysical origin performed within the framework of the Standard-Model Extension is provided. For this effective field theory, key definitions, intriguing physical consequences, and the mathematical formalism are summarized within the neutrino sector to search for effects from a background that could lead to small deviations from Lorentz symmetry. After an introduction to the fundamental theory, examples of various experiments within the astronomical and astrophysical context are provided. Order-of-magnitude bounds of SME coefficients are shown illustratively for the tight constraints that this sector allows us to place on such violations.
Metal Cation Triggered Peptide Hydrogels and Their Application in Food Freshness Monitoring and Dye Adsorption
Authors: Fortunato Anna , Mba Miriam
Published: July 2021

Metal-ligand interactions have emerged as an important tool to trigger and modulate self-assembly, and to tune the properties of the final supramolecular materials. Herein, we report the metal-cation induced self-assembly of a pyrene–peptide conjugate to form hydrogels. The peptide has been rationally designed to favor the formation of β-sheet 1D assemblies and metal coordination through the Glu side chains. We studied in detail the self-assembly process in the presence of H+, Li+, Na+, K+, Ca2+, Ni2+, Cu2+, Zn2+, Cd2+, Co2+, Fe3+, and Cr3+ and found that the morphology and mechanical properties of the hydrogels are ion-dependent. Moreover, thanks to the presence of the metal, new applications could be explored. Cu2+ metallogels could be used for amine sensing and meat freshness monitoring, while Zn2+ metallogels showed good selectivity for cationic dye adsorption and separation.
Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods
Authors: Pinto Tiago C. , Martins Artur J. , Pastrana Lorenzo , Pereira Maria C. , Cerqueira Miguel A.
Published: July 2021

Oleogels are semi-solid materials containing a large fraction of liquid oil entrapped in a network of structuring molecules. In the food industry, these formulations can be used to mimic fats and to deliver bioactive compounds. In the last decade, there has been increasing interest in these structures, not only from a scientific point of view, i.e., studying new molecules, methodologies for gelification, and new structures, but also from a technological point of view, with researchers and companies exploring these structures as a way to overcome certain challenges and/or create new and innovative products. One of the exciting applications of oleogels is the delivery of functional molecules, where the incorporation of oil-soluble functional compounds can be explored not only at the macroscale but also at micro- and nanoscales, resulting in different release behaviors and also different applications. This review presents and discusses the most recent works on the development, production, characterization, and applications of oleogels and other oleogel-based systems to deliver functional molecules in foods.
A Genomic Approach to Delineating the Occurrence of Scoliosis in Arthrogryposis Multiplex Congenita
Authors: Latypova Xenia , Creadore Stefan Giovanni , Dahan-Oliel Noémi , Gustafson Anxhela Gjyshi , Wei-Hung Hwang Steven , Bedard Tanya , Shazand Kamran , van Bosse Harold J. P. , Giampietro Philip F. , Dieterich Klaus
Published: July 2021

Arthrogryposis multiplex congenita (AMC) describes a group of conditions characterized by the presence of non-progressive congenital contractures in multiple body areas. Scoliosis, defined as a coronal plane spine curvature of ≥10 degrees as measured radiographically, has been reported to occur in approximately 20% of children with AMC. To identify genes that are associated with both scoliosis as a clinical outcome and AMC, we first queried the DECIPHER database for copy number variations (CNVs). Upon query, we identified only two patients with both AMC and scoliosis (AMC-SC). The first patient contained CNVs in three genes (FBN2, MGF10, and PITX1), while the second case had a CNV in ZC4H2. Looking into small variants, using a combination of Human Phenotype Ontogeny and literature searching, 908 genes linked with scoliosis and 444 genes linked with AMC were identified. From these lists, 227 genes were associated with AMC-SC. Ingenuity Pathway Analysis (IPA) was performed on the final gene list to gain insight into the functional interactions of genes and various categories. To summarize, this group of genes encompasses a diverse group of cellular functions including transcription regulation, transmembrane receptor, growth factor, and ion channels. These results provide a focal point for further research using genomics and animal models to facilitate the identification of prognostic factors and therapeutic targets for AMC.
A Multidisciplinary Approach to Evaluate the Effectiveness of Natural Attenuation at a Contaminated Site
Authors: Zanini Andrea , Ghirardi Marco , Emiliani Renata
Published: July 2021

This study evaluates the natural attenuation of chlorinated hydrocarbons as remediation action in a contaminated site downtown the city of Parma (Italy). To achieve this goal, a combination of new investigation methods (bio-molecular analysis, compound specific isotope analysis, phytoscreening) has been proposed. The approach (named circular multi step) allows to: fully understand the phenomena that occur at the study site, design new investigation activities, and manage best practices. Consequently, each step of the approach improves the conceptual and numerical models with new knowledge. The activities carried out at the study site allowed to detect a contamination of perchloroethylene in a large part of the city of Parma and, of main importance, underneath a kindergarten. The results of the study did not show significant natural attenuation of chlorinated hydrocarbons and that the detected contamination could refer to the same unknown contaminant source. Furthermore, the innovative phytoscreening technique was applied to assess the presence of chlorinated hydrocarbons at the ground level. The plume spread was estimated through numerical modeling starting from potential contaminant sources. This study enhances the knowledge of groundwater flow and contamination in Parma and allows authorities to design new investigation/reclamation activities through management actions.
Sleep, Physical Activity, and Diet of Adults during the Second Lockdown of the COVID-19 Pandemic in Greece
Authors: Papazisis Zisis , Nikolaidis Pantelis T. , Trakada Georgia
Published: July 2021

The aim of the present study was to evaluate the possible correlations between sleep, physical activity, and diet in the general population of Greece during the second lockdown due to COVID-19 pandemic. A web-based questionnaire including 28 items was completed by 494 adults (age 31.5 ± 12.4 years). Half of the participants (49.8%) reported good, 44.1% moderate, and 6.1% bad quality of sleep, whereas 17.2% answered that the quality of sleep improved, 56.5% did not change, and 26.3% worsened compared to a normal week. Compared to normal, sleep duration in lockdown increased by 0.24 h (95% CI; 0.13, 0.35; p < 0.001, d = 0.198). More under-weight (32.4%) and obese (34.1%) respondents reported worsened quality of sleep in lockdown compared with normal (25.6%) and overweight participants (22.7%) (p = 0.006, Cramer’s φ = 0.191). A small effect for BMI group on sleep duration was observed (p = 0.011, η2 = 0.023), where overweight and obese slept less (–0.44 h and –0.66 h, respectively) than normal weight participants. Subjects with the highest percentage of increased food consumption reported decreased sleep duration (p = 0.012) and worsened sleep quality (p = 0.003). Compared with a normal week, physical activity of a high and moderate intensity decreased for 43.0% and 37.0% of participants, did not change in 32.9% and 36.1% of participants, and increased in 24.1% 26.9%, respectively, whereas walking time decreased in 31.3%, did not change in 27.3%, and increased in 41.5% of participants. Increased high and moderate intensity physical activity was related with an improvement in sleep quality (p < 0.001). Those with decreasing walking time reported the highest percentage of decreased sleep quality (p = 0.006) and worsened sleep quality (p = 0.016). In conclusion, both quality and quantity of sleep were impaired during the second lockdown and the observed changes were associated with diet and physical activity.
The Effects of Patients’ and Caregivers’ Characteristics on the Burden of Families Caring for Stroke Survivors
Authors: Kavga Anna , Kalemikerakis Ioannis , Faros Anastasios , Milaka Maria , Tsekoura Dimitra , Skoulatou Maria , Tsatsou Ioanna , Govina Ourania
Published: July 2021

Background: Vascular strokes are the leading cause of long-term disability for adults. They impose high levels of burden on the patient, the family, and national healthcare systems worldwide. This study aimed to assess the effects of patients’ and caregivers’ characteristics on the perceptions of burden in families caring for a loved one living with stroke in Greece. Methods: Using purposive sampling, 109 dyads of patients and their respective caregivers were recruited from the Attica region. Patients completed a questionnaire that included personal characteristics and the Barthel Index, while caregivers completed a set of questionnaires—personal characteristics, revised Bakas Caregiving Outcomes Scale (BCOS), Personal Resource Questionnaire (PRQ 2000), and Center for Epidemiological Studies-Depression (CES-D). Results: Caregiving burden was linked to both patients’ and caregivers’ characteristics. A patient’s educational level, the number of family members living in the same house, the existence of equipment and facilities in the house, and the duration of provided care were associated with perception of greater burden. Regarding caregivers’ characteristics, those in good health had a significantly lower perception of burden. Higher PRQ 2000 scores were significantly associated with higher BCOS scores (less burden), and higher CES-D scores were significantly associated with lower BCOS scores (more burden). Conclusion: Caring for a loved one affected by stroke places a considerable burden on the caregiver. Systematic assessment and intervention strategies can help to identify caregivers at risk so that suitably targeted assistance may be provided.
Overeaters Anonymous: An Overlooked Intervention for Binge Eating Disorder
Authors: Bray Brenna , Rodríguez-Martín Boris C. , Wiss David A. , Bray Christine E. , Zwickey Heather
Published: July 2021

The purpose of this communication is to provide an overview as well as the strengths and weaknesses of Overeaters Anonymous (OA) as an intervention for binge eating disorder treatment. Binge eating disorder is associated with low remission rates, high relapse rates, treatment dissatisfaction, and high rates of failure to receive treatment attributed to stigma, misconceptions, lack of diagnosis, access to care, and inadequate insurance coverage. New interventions are needed that can overcome these barriers. OA is a twelve-step program and established fellowship for individuals who self-identify as having problematic relationships with food or eating. OA can be referred clinically or sought out by an individual confidentially, without a diagnosis, and free of charge. OA’s Nine Tools, Twelve Steps, and Twelve Traditions can provide structure, social support, and open, anonymous sharing that fosters a sense of connection and belonging. This may provide benefit to individuals who value structure and social support in their recovery. The tradition of anonymity may also create some challenges for conducting research and may explain the shortage of empirical support. This commentary reviews existing research findings on the effectiveness of twelve-step interventions and OA. Common misunderstandings about and within OA are also addressed and OA’s limitations are discussed. Overall, OA provides a promising option for binge eating disorder treatment that warrants clinical research on its feasibility and efficacy in a way that respects and protects its tradition of anonymity.
Interorganizational Networks in Physical Activity Promotion: A Systematic Review
Authors: Timm Irina , Rapp Simone , Jeuter Christian , Bachert Philip , Reichert Markus , Woll Alexander , Wäsche Hagen
Published: July 2021

Public health challenges such as physical inactivity are multiplex and cannot be effectively addressed by single organizations or sectors. For this reason, public health policies have to involve various sectors and foster partnerships among organizations. Social network analysis (SNA) provides a methodological toolkit that enables the investigation of relationships between organizations to reveal information about the structure and cooperation within networks. This systematic review provides an overview of studies utilizing SNA to analyze the structure of networks that promote physical activity, including the structural set-up, types, and conditions of cooperation, the existence or absence of key actors, the characteristics of organizations working together, and potential barriers limiting collaboration. In total, eight eligible studies were identified. To evaluate the quality of these studies, a quality assessment tool for SNA was created. Relevant aspects from each study were systematically outlined using a data extraction template developed for network studies. The studies reported low to moderate density scores with many ties not being realized. Organizations tend to work side by side than as real partners, whereas organizations of the same type are more strongly connected. Most of the studies identified governmental health organizations as key players in their networks. Network maturity influences network outcomes. Shared goals and geographic proximity are potential facilitators for network development. For future research, more sophisticated methods and longitudinal studies are required to describe how networks, with the aim of promoting physical activity, develop and change to identify predicting factors for an effective network structure.
Emotional Demand and Mental Health in Korean Employees
Authors: Kwon Soon-Chan , Kim Inah , Kim Yu-Mi
Published: July 2021

Background: Emotional demand (ED) at work is related to mental health in the general workforce, not just emotional workers. We investigated the relationships between ED and mental health outcomes, including distress, depressive symptoms (DS), experience of depression (DE), and suicidal ideation (SI) on the entire general workforce using nationally representative data. Methods: 5787 full-time employees were analyzed using cross-sectional design with the fourth Korean National Health and Nutrition Examination Survey (K-NHANES IV). Work-related psychosocial factors and mental health status were measured through face-to-face interviews. Multi-stage and stratified survey designs were considered in the analysis, and the mental health effects of ED were analyzed using multivariable logistic analysis. The Cochran–Armitage trend test was conducted to investigate increases in the relationship between the severity of ED and mental health outcomes. Results: The subjects comprised 3089 men and 2698 women. ED was reported by 36.7% of men and 39.3% of women. The estimated prevalence of distress was 27.5% in men and 34.6% in women. Adjusted odds ratios (ORs) of ED for distress were 2.62 (95% confidence interval (CI) = 2.10–3.28) for men and 2.57 (95% CI = 1.92–3.45) for women. DS was significantly related to ED (men: OR = 1.72, 95% CI = 1.18–2.50; women: OR = 1.91, 95% CI = 1.33–2.74). ED was also significant psychosocial risk factor for DE (men: OR = 1.88, 95% CI = 1.07–3.29; women: OR = 1.77, 95% CI = 1.15–2.75) and SI (men: OR = 1.64, 95% CI = 1.11–2.41; women: OR = 2.31, 95% CI = 1.63–3.28). Conclusions: ED was a risk factor for distress, DS, DE, and SI in the general workforce. Legal and social safety networks should be constructed for workers whose emotions may be hidden at work, as well as workers in emotion-related fields.
Child and Adolescent Mental Health and Resilience-Focussed Interventions: A Conceptual Analysis to Inform Future Research
Authors: Dray Julia
Published: July 2021

Internationally, the mental health of children and adolescents is undoubtedly an important construct of theoretical, clinical, and policy level concern. Worldwide, five mental disorders (depression, alcohol misuse, bipolar affective disorder, schizophrenia, and obsessive-compulsive disorder) represent half of the 10 leading causes of disability and premature death; with mental disorders accounting for 15–30% of disability adjusted life years in the first three decades of life. This provides a solid rational founded in implications for population health as to why reducing and preventing mental health problems in children and adolescents deserves attention. Past research has indicated interventions focussed on building resilience through strengthening protective factors may offer the potential to address mental health problems in children and adolescents, and in particular aid in reducing such problems during times of increased risk or adversity. With childhood and adolescence being critical periods of development, there is a need to reflect on the strengths and limitations of resilience-focussed interventions and anticipated future needs of the world’s youth. This conceptual analysis identifies a number of future research directions that may meaningfully add to the evidence base and improve implementation, evaluation, and impact of resilience-focussed interventions. These largely relate to refining the understanding of how resilience protective factors relate to mental health problems in children and adolescents. Important issues and potential opportunities to improve the related research field include improved reporting of intervention content; improved measurement of resilience protective factors in intervention trials; continued reporting and review of evidence of association between protective factors and mental health outcomes; and incorporation of mediation analysis within intervention trials. There is a need for further intervention studies in this space to be conducted as rigorous trials of resilience-focussed approaches based on such evidence of association, with clearly posited mechanisms of change, and inclusive of analysis of differential intervention effects. The suggested implications for research made in this conceptual analysis will aid in improving the quality of the evidence base relevant to the fostering of resilience and prevention of mental health problems in children and adolescents.
Prolonged Stress Causes Depression in Frontline Workers Facing the COVID-19 Pandemic—A Repeated Cross-Sectional Study in a COVID-19 Hub-Hospital in Central Italy
Authors: Magnavita Nicola , Soave Paolo Maurizio , Antonelli Massimo
Published: July 2021

The COVID-19 pandemic has severely tested the mental health of frontline health care workers. A repeated cross-sectional study can provide information on how their mental health evolved during the various phases of the pandemic. The intensivists of a COVID-19 hub hospital in Rome were investigated with a baseline survey during the first wave of the pandemic in April 2020, and they were contacted again in December 2020, during the second wave. Of the 205 eligible workers, 152 responded to an online questionnaire designed to measure procedural justice, occupational stress (effort/reward imbalance), sleep quality, anxiety, depression, burnout, job satisfaction, happiness, and turnover intention. Workers reported a further increase in workload and compassion fatigue, which had already risen during the first wave, and a marked reduction in the time devoted to meditation and mental activities. A low level of confidence in the adequacy of safety procedures and the need to work in isolation, together with an increased workload and lack of time for meditation, were the most significant predictors of occupational stress in a stepwise linear regression model. Occupational stress was, in turn, a significant predictor of insomnia, anxiety, low job satisfaction, burnout, and intention to leave the hospital. The number of workers manifesting symptoms of depression increased significantly to exceed 60%. Action to prevent occupational risks and enhance individual resilience cannot be postponed.
Coping Strategies Used by Older Adults to Deal with Contact Isolation in the Hospital during the COVID-19 Pandemic
Authors: Boumans Jogé , Scheffelaar Aukelien , van Druten Vera P. , Hendriksen Tessel H. G. , Nahar-van Venrooij Lenny M. W. , Rozema Andrea D.
Published: July 2021

Due to the COVID-19 pandemic, many older adults have experienced contact isolation in a hospital setting which leads to separation from relatives, loss of freedom, and uncertainty regarding disease status. The objective of this study was to explore how older adults (55+) cope with contact isolation in a hospital setting during the COVID-19 pandemic in order to improve their physical and psychological wellbeing. The realist evaluation approach was used to formulate initial program theories on coping strategies used by (older) adults in an isolation setting. Twenty-one semi-structured interviews with older patients (n = 21) were analysed. This study revealed that both emotion-focused coping strategies as well as problem-focused coping strategies were used by older adults during contact isolation. The study also uncovered some new specific coping strategies. The results have useful implications for hospital staff seeking to improve the wellbeing of older adults in contact isolation in hospitals. Problem-focused coping strategies could be stimulated through staff performing care in a person-centred way. Trust in staff, as part of emotion-focused coping strategies, could be stimulated by improving the relationship between patients and staff.
Neurophysiological Stress Response and Mood Changes Induced by High-Intensity Interval Training: A Pilot Study
Authors: Martínez-Díaz Inmaculada C. , Carrasco Luis
Published: July 2021

This pilot study, conducted in advance of a future definitive randomized controlled trial, aimed to investigate the feasibility of using a HIIT-based intervention to induce neurophysiological stress responses that could be associated with possible changes in mood. Twenty-five active male college students with an average age of 21.7 ± 2.1 years, weight 72.6 ± 8.4 kg, height 177 ± 6.1 cm, and BMI: 23.1 ± 1.4 kg/m2 took part in this quasi-experimental pilot study in which they were evaluated in two different sessions. In the first session, subjects performed a graded exercise test to determine the cycling power output corresponding to VO2peak. The second session consisted of (a) pre-intervention assessment (collection of blood samples for measuring plasma corticotropin and cortisol levels, and application of POMS questionnaire to evaluate mood states); (b) exercise intervention (10 × 1-min of cycling at VO2peak power output); (c) post-intervention assessment, and (d) 30-min post-intervention evaluation. Significant post-exercise increases in corticotropin and cortisol plasma levels were observed whereas mood states decreased significantly at this assessment time-point. However, a significant increase in mood was found 30-min after exercise. Finally, significant relationships between increases in stress hormones concentrations and changes in mood states after intense exercise were observed. In conclusion, our HIIT-based intervention was feasible to deliver and acceptable to participants. A single bout of HIIT induced acute changes in mood states that seems to be associated with hypothalamic-pituitary-adrenal axis activation.