EFFECT OF STANDARDIZED EXTRACTS OF CECROPIA OBTUSIFOLIA BERTOL. ON METABOLIC SYNDROME IN MICE
Authors: Jiménez-Ferrer Enrique , Moreno-Hernández Yolot , González-Cortázar Manasés , Zamilpa Alejandro , Herrera-Ruiz Maribel , Gómez-Rivera Abraham , Aguilar-Santamaría Lucía L. 
Published: September 2022

Background: In Mexican traditional medicine, Cecropia obtusifolia is extensively used, from central to southeast regions, to treat diabetes and some inflammation-related disorders, including renal illness and obesity.
Objective: To evaluate the effect of the hydroalcoholic and methanolic extracts, standardized in chlorogenic acid, on some metabolic syndrome-related signs induced by hypercaloric diet in mice.
Methods: C57BL/6 mice were administered the hydroalcoholic or the methanolic extract for 8 weeks. The data were analyzed with a one-way ANOVA followed by Tukey post hoc test.
Results: Methanolic extract was able to reduce insulin resistance, clotting time, adipose tissue content, food consumption, weight gain, and hypertension. It also decreased renal inflammation, as assessed by the quantification of TNF-α, IL-6, and IL-10. On the other hand, the hydroalcoholic extract, vs negative control, decreased IL-6 (-60.4%) and TNF-α (-82.1%) and increased IL-10 (39.1%).  
Conclusion: Overall, the methanolic extract had higher efficacy, since it reduced insulin resistance and visceral fat and showed a tendency to reduce clotting time, which may be related to improve liver function.
                       
Peer Review History:
Received: 11 July 2022; Revised: 15 August; Accepted: 8 September, Available online: 15 September 2022
Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa
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Received file:                                Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com
Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
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