bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Efficacy and Safety of Percutaneous Curved Vertebroplasty in Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta‐Analysis
Authors: Sun Yan , Zhang Yong , Ma Haoning , Tan Mingsheng , Zhang Zhihai
Published: July 2023

This systematic review and meta‐analysis is aimed to provide higher quality evidence regarding the efficacy and safety between PCVP and PVP/KP in OVCFs. We searched the Cochrane Library, PubMed, Web of Science, and Embase databases for all randomized controlled trials (RCTs) and observational studies (cohort or case–control studies) that compare PCVP to PVP/KP for OVCFs. The Cochrane Collaboration's Risk of Bias Tool and Newcastle–Ottawa Scale (NOS) were used to evaluate the quality of the RCTs and non‐RCTs, respectively. Meta‐analysis was performed using RevMan 5.4 software. A total of seven articles consisting of 562 patients with 593 diseased vertebral bodies were included. Statistically significant differences were found in the postoperative visual analog scale (VAS) at 1 day (MD = −0.11; 95% CI: [−0.21 to −0.01], p = 0.03), but not at 3 months (MD = −0.21; 95% CI: [−0.41–0.00], p = 0.05) or 6 months (MD = 0.03; 95% CI: [−0.13–0.20], p = 0.70). There was no statistically significant difference in postoperative Oswestry disability index (ODI) at 1 day (MD = −0.28; 95% CI: [−0.62–0.05], p = 0.10), 3 months (MD = −1.52; 95% CI: [−3.11–0.07], p = 0.06), or 6 months (MD = 0.18; 95% CI: [−0.13–0.48], p = 0.25). Additionally, there were no statistically significant differences in Cobb angle (MD = 0.30; 95% CI: [−1.69–2.30], p = 0.77) or anterior vertebral body height (SMD = −0.01; 95% CI: [−0.26–0.23], p = 0.92) after surgery. Statistically significant differences were found in surgical time (MD = −8.60; 95% CI: [−13.75 to −3.45], p = 0.001), cement infusion volume (MD = −0.82; 95% CI: [−1.50 to −0.14], P = 0.02), and dose of fluoroscopy (SMD = −1.22; 95% CI: [−1.84 to −0.60], p = 0.0001) between curved and noncurved techniques, especially compared to bilateral PVP. Moreover, cement leakage showed statistically significant difference (OR = 0.40; 95% CI: [0.27–0.60], p < 0.0001). Compared with PVP/KP, PCVP is superior for pain relief at short‐term follow‐up. Additionally, PCVP has the advantages of significantly lower surgical time, radiation exposure, bone cement infusion volume, and cement leakage incidence compared to bilateral PVP, while no statistically significant difference is found when compared with unilateral PVP or PKP. In terms of quality of life and radiologic outcomes, the effects of PCVP and PVP/KP are not significantly different. Overall, this meta‐analysis reveals that PCVP was an effective and safe therapy for patients with OVCFs.
Management of acute sloughing of the esophageal lining in patients with dystrophic epidermolysis bullosa—A series of six pediatric patients
Authors: Bageta Maria Laura , Yerlett Natalie , Rybak Anna , Balboa Pablo Lopez , Petrof Gabriela , Martinez Anna E.
Published: July 2023

Background

Dystrophic epidermolysis bullosa (DEB) is a subtype of an inherited skin disorder characterized by skin and mucosal fragility due to collagen VII (COL7A1) gene mutations. Esophageal strictures leading to chronic dysphagia and acute episodes are well recognized complications within this subtype. Sloughing of esophageal mucosa and the treatment of this emergency have heretofore received limited attention in the EB literature.

Methods

We retrospectively reviewed the electronic medical records of the patients who had an acute episode of sloughing of the esophageal lining between 2008 and 2021 and extracted the information regarding their clinical presentation and management.

Results

Six patients out of 210 with recessive DEB severe (RDEB‐S) (n = 4), RDEB intermediate (RDEB‐I) (n = 1) and dominant DEB (DDEB) (n = 1) were identified. The mean age at the time of the episode was 2.7 years. All patients had early‐onset severe gastroesophageal reflux. Clinically, they presented with a coughing episode (n = 6), hematemesis (n = 6), vomiting (n = 6), and choking (n = 3), followed by coughing up a string like tissue of variable length, part of the esophageal mucosal lining. Four patients recovered with medical management only, two patients required gastrostomy insertions for feeding due to severe persistent dysphagia and one also required a Nissen's fundoplication to manage severe reflux. One patient had aspiration pneumonia.

Conclusions

Sloughing of varying lengths of segments of the esophagus is an emergency. The lining coughed up needs to be cut at the mouth not pulled and the emergency services called immediately for urgent assessment and management. Expert multidisciplinary care is needed to manage this rare but serious condition.
Theorizing reactive policy entrepreneurship: A case study of Swedish local emergency management
Authors: Petridou Evangelia , Johansson Roine , Eriksson Kerstin , Alirani Gertrud , Zahariadis Nikolaos
Published: July 2023

In this article, we examine public policy change at the local level of governance in the aftermath of an extraordinary event. Using the case study of a Swedish municipality after the sweeping forest fire of 2014, we contend that policy entrepreneurship, like its market counterpart, may under certain conditions take on a wider range of behaviors that are not underpinned by the proactive quest for opportunities. Rather, a sense of urgency and necessity, professional norms, and some keen technical skills make for a different kind of entrepreneurship, which we label reactive policy entrepreneurship.
Developing HIV risk prediction tools in four African settings
Authors: Kansiime Sheila , Hansen Christian Holm , Hayes Richard , Ruzagira Eugene ,   the PrEPVacc Study Team
Published: July 2023

Objective

HIV risk prediction tools are a critical component of efforts to end the HIV pandemic. We aimed to create and validate tools for identifying individuals at highest risk of prevalent and incident HIV in an African setting.

Methods

We used Logistic regression and Poisson regression to determine risk factors for HIV prevalence and incidence in a multi‐country HIV vaccine trial preparedness cohort study among individuals at high risk of HIV, and used the identified factors to create and validate tools that predict HIV risk. We also assessed the performance of the VOICE risk score in predicting HIV incidence among women in the cohort.

Results

The prevalent HIV prediction tool created had good predictive ability [area under the curve (AUC) = 0.70, 95% CI 0.66–0.74]. It included the following participant variables: age, sex, recreational drug use, unprotected male‐to‐male anal sex, a sexual partner who had other partners, transactional sex and having a partner who was a long‐distance truck driver/miner. It was not possible to create a valid HIV incidence prediction tool. Participants with high VOICE risk scores (≥7) had slightly higher HIV incidence but this tool performed poorly within our study (AUC = 0.58, 95% CI 0.51–0.64: Harrell's concordance index = 0.59).

Conclusion

We created a prevalent HIV prediction tool that could be used to increase efficiency in diagnosis of HIV and linkage to care in sub‐Saharan Africa. Existing incident HIV prediction tools may need modification to include context‐specific predictors such as calendar period, participant occupation, study site, before adoption in settings different from those in which they were developed.
Fractional fuzzy PI controller using particle swarm optimization to improve power factor by boost converter
Authors: Demirtas Metin , Ahmad Farhan
Published: July 2023

The power circuit of AC voltage controller capable of operating at a leading, lagging, and unity power factor is studied by a lot of researchers in the literature. Circuits working with high switching frequency are known as power factor correctors (PFCs). The single-phase boost converter has become the most popular topology for power factor correction (PFC) in general purpose power supplies. Power factor correction circuit provides conventional benefits to electric power systems. The benefits are the reduction of power factor penalty and utility bill and power loss. Therefore, a boost converter power factor correction scheme is presented in this paper. A PI, fuzzy logic PI and fractional order PI (FOPI) controllers are used to fix an active shaping of input current of the circuit and to improve the power factor. The controller parameters (coefficients) are optimized using the Particle Swarm Optimization (PSO) algorithm. Average current mode control (ACMC) method is used in the circuit. The converter circuit consists of a single-phase bridge rectifier, boost converter, transformer and load. A mathematical model of the plant is required to design the PI controller. A model for power factor correction circuit is formed in MATLAB/Simulink toolbox and a filter is designed to reduce THD value. The proposed model is simulated using a combination of PI, fuzzy logic and FOPI controllers. The control scheme is applied to 600 Watt PFC boost converter to get 400 Volt DC output voltage and 0.99 power factor. The input voltage is 230 VRMS with 50 Hz. The combination of FOPI and PI controller has the best solution to control the power factor according to PI and fuzzy controllers.
Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate
Authors: Rajizadeh Mohammad‐Amin , Hosseini Mahdiyeh Haj , Bahrami Mina , Hosseini Najmeh Sadat , Rostamabadi Fahimeh , Bagheri Fatemeh , Khoramipour Kayvan , Najafipour Hamid , Bejeshk Mohammad‐Abbas
Published: July 2023

Methotrexate (Mtx) is used to treat various diseases, including cancer, arthritis and other rheumatic diseases. However, it induces oxidative stress and pulmonary inflammation by stimulating production of reactive oxygen species and cytokines. Considering the positive effects of physical activity, our goal was to investigate the preventive and therapeutic role of continuous training (CT) on Mtx‐induced lung injury in rats. The rats were divided into five groups of 14 animals: a control group (C); a continuous exercise training group (CT; healthy rats that experienced CT); an acute lung injury with Mtx group (ALI); a pretreatment group with CT (the rats experienced CT before ALI induction), and a post‐treatment group with CT (the rats experienced CT after ALI induction). One dose of 20 mg/kg Mtx intraperitoneal was administered in the Mtx and training groups. Forty‐eight hours after the last exercise session all rats were sacrificed. According to our results, the levels of tumour necrosis factor‐α (TNF‐α), malondialdehyde (MDA), myeloperoxidase (MPO), GATA binding protein 3 (GATA3) and caspase‐3 in the ALI group significantly increased compared to the control group, and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), interleukin‐10 (IL‐10), forkhead box protein 3 (FOXP3), and T‐bet decreased. In contrast, compared to the acute lung injury group, pretreatment and treatment with CT reduced TNF‐α, MDA, MPO, GATA3 and caspase‐3 and increased SOD, GPX, TAC, IL‐10, FOXP3 and T‐bet levels. The effects of CT pretreatment were more significant than the effects of CT post‐treatment. Continuous exercise training effectively reduced oxidative stress and inflammatory cytokines and ameliorated Mtx‐induced injury, and the effects of CT pretreatment were more significant than the effects of CT post‐treatment.
Experimental Investigation and Controllability Study of Electrochemical Actuators Based on Si/CNTs Composite Material
Authors: Wu Zhilin , Yang Xiaobin , Sheng Kai , Li Dawei
Published: July 2023

Electrochemical actuators can convert electrical energy into mechanical energy directly and have been applied widely. With a large volume expansion in the electrochemical reaction, silicon material demonstrates enormous potential in the manufacture of electrochemical actuators. Here, we propose a new electrochemical actuator based on Si/CNTs composite electrode. A mathematical model is developed to analyze the relationship among material parameters, structural changes, and bending deformation. The curvature changes of the cantilever beam are captured by a charge-coupled device (CCD) camera during electrochemical cycling. Combining the model and bending curvatures, the modulus and swell strain are extracted and analyzed in detail. Here, the elastic modulus of the composite electrode softens and decreases from 9.59 GPa to 4.78 GPa, while the swell strain increases from 0.12% to 2.97% when arriving 6% normalized concentration of lithium. These results show that the composite material possesses excellent bending resistance and deformation ability. Also, the curvature changes under different thickness ratios are predicted successfully, the evolution of stress in the working electrode is simulated, and the loading experiment of the actuator is carried out. This work provides a new way to realize the controllability of the electrochemical actuators.
Developing Turbulent Convective Heat Transfer in Helical Pipes
Authors: Lin C. X. , Ebadian M. A.
Published: July 2023

A fully elliptic numerical study has been carried out to investigate three-dimensional turbulent developing convective heat transfer in helical pipes with finite pitches. The k-ε standard two-equation turbulence model is used to simulate turbulent flow. The turbulent flow and heat transfer are assumed to develop simultaneously. Uniform inlet velocity and constant wall temperature conditions are applied. The governing equations are solved by a Control-Volume Finite Element Method (CVFEM). Numerical results have been compared to the existing experimental data, and a good agreement has been obtained. The results presented in this paper cover a Reynolds number range of 2.5 × 104–1.0 × 105, a pitch range of 0.0–0.6, and a curvature ratio range of 0.025–0.050. The developments of effective thermal conductivity, temperature fields, and local and average Nusselt numbers are given and discussed. It has been found that the examined parameters exert complex effects on the developing thermal fields and heat transfer in the helical pipes. The Nusselt numbers for the helical pipes are oscillatory before the flow is fully developed, especially for the case of a relatively large curvature ratio.
Application of Metallic Nanoparticle Suspensions in Advanced Cooling Systems
Authors: Lee Shinpyo , Choi Stephen U.-S.
Published: July 2023

One of the authors has proposed that an innovative new class of energy-efficient heat transfer fluids can be engineered by suspending nanometer-sized metallic particles (nanoparticles) in conventional heat transfer fluids. The resulting “nanofluids” are expected to exhibit much higher thermal conductivities than those of currently used heat transfer fluids and represent the best hope for high-performance cooling in next-generation cooling systems. In this study, the advanced cooling technology has been applied to cooling crystal silicon mirrors used in high-intensity X-ray sources such as Argonne’s Advanced Photon Source. Because the X-ray beam creates tremendous heat as it strikes the mirror, cooling rates of 2000–3000 W/cm2 must be achievable with the advanced technology.

Analysis has been carried out to estimate the performance of microchannel heat exchangers with water, liquid nitrogen, and nanofluids as the working fluid. The design and optimization procedures for microchannel heat exchangers show the existence of an optimal channel width that minimizes the thermal resistance of a microchannel heat exchanger. For a pressure drop of 210 kPa (30 psi), the optimized channel width and depth are 56 μm and 360 μm for a water-cooled silicon heat sink and 39 μm and 1410 μm for a liquid-nitrogen-cooled silicon heat sink. For the optimized configuration, performance of the nanofluid-cooled microchannel heat exchanger has been compared with that of a water-cooled and liquid-nitrogen-cooled microchannel heat exchanger. The results show the superiority of a nanofluid-cooled microchannel heat exchanger. When nanofluids are used, the thermal resistances are reduced and the power densities are increased. Excellent thermal performance of a silicon microchannel heat exchanger has been demonstrated when nanofluids were used as the room temperature coolant.
Investigation of Die Polishing Strategies Using Five-Axis Machining Centre
Authors: Clayton P. A. , Elbestawi M. A.
Published: July 2023

This paper investigates the automated grinding and polishing of dies and molds using a five-axis milling machine. Automating the die bench working process not only saves on labour costs and removes workers from a difficult and dirty task, but also reduces lead times as well as shape errors. Bench working is the process of bring the die to its final shape and appearance with only a minimal of metal removal. The removal of cusps from the surface of the die is the first stage. Once the net shape has been obtained the die is polished to a mirror like surface finish. The first stage of the project was the development of a mechanistic grinding model to help determine the forces that would be encountered during cusp removal. Using this information a passive polishing tool was designed and constructed that fit inside a standard 25.4mm (1″) collet as would any other tool. The rotational velocity for the force control polishing tool was supplied by the spindle itself. The mechanistic model was verified with subsequent grinding tests. Both Ol and P20 tool steel were used while employing the Taguchi method to determine the optimal parameters (rotational speed, force, feed, etc.) for the polishing of the die. Additionally, the traditional S-pattern polishing path was compared to a fractal pattern proposed by Mizugaki and Sakamoto (1992). The system has proven to be a viable alternative to manual polishing of dies.
Cobots: Robots for Collaboration With Human Operators
Authors: Colgate J. Edward , Wannasuphoprasit Witaya , Peshkin Michael A.
Published: July 2023

A “cobot” is a robotic device which manipulates objects in collaboration with a human operator. A cobot provides assistance to the human operator by setting up virtual surfaces which can be used to constrain and guide motion. While conventional servo-actuated haptic displays may be used in this way also, an important distinction is that, while haptic displays are active devices which can supply energy to the human operator, cobots are intrinsically passive. This is because cobots do not use servos to implement constraint, but instead employ “steerable” nonholonomic joints. As a consequence of their passivity, cobots are potentially well-suited to safety-critical tasks (e.g. surgery) or those which involve large interaction forces (e.g. automobile assembly). This paper focuses on the simplest possible cobot, which has only a single joint (a steerable wheel). Two control modes of this “unicycle cobot”, termed “virtual caster” and “virtual wall” control, are developed in detail. Experimental results are also presented.
A Low Power, Tight Seal, Polyimide Electrostatic Microvalve
Authors: Lee Abraham P. , Hamilton Julie , Trevino Jimmy
Published: July 2023

An electrostatically-actuated polyimide microvalve with low power consumption (< 1mW) is presented in this paper. Bias voltage applied across a sub-micron gap between the sealing electrodes generates a large electrostatic force (1.3N) resulting in a tight seal for the valve. Built-in residual stress results in a curled bimorph cantilever which allows for a microactuator with large displacement. This microactuator is used to open and close a fluid path hole etched in silicon for a microvalve. The microactuator can be actuated with 25V for a displacement of 200 μm. The cantilever actuator is mainly composed of polyimide, which is flexible enough to conform over the flow hole, thereby eliminating the need for the design of a valve seat.
Enhancing the Initial Acceleration Performance of Elite Rugby Backs. Part I: Determining Individual Technical Needs
Authors: Wild James J. , Bezodis Ian N. , North Jamie S. , Bezodis Neil E.
Published: July 2023

Purpose: This study sought to quantify the within-individual relationships between spatiotemporal variables and initial acceleration sprint performance in elite rugby backs and to establish a normative data set of relevant strength-based measures. Methods: First, the spatiotemporal variables, ratios of step length to step rate and of contact time to flight time, and initial acceleration performance were obtained from 35 elite male rugby backs (mean [SD] age 25 [3] y) over the first 4 steps of 3 sprints. Angular and linear kinematic aspects of technique and strength-based qualities were collected from 25 of these participants. Second, the same spatiotemporal variables were collected from 19 of the participants on 3 further occasions (12 trials in total) to determine the within-individual associations of these variables and initial acceleration performance. Results: Moderate to very large meaningful within-individual relationships (|r| = .43–.88) were found between spatiotemporal variables and initial acceleration performance in 17 of the 19 participants. From these relationships, a theoretically “desirable” change in whole-body kinematic strategy was individually determined for each participant, and normative strength-based measures to contextualize these were established. Conclusions: Meaningful within-individual relationships are evident between sprint spatiotemporal variables and initial acceleration performance in elite rugby backs. Individualized approaches are therefore necessary to understand how aspects of technique relate to initial acceleration performance. This study provides an objective, evidence-based approach for applied practitioners to identify the initial acceleration technical needs of individual rugby backs.
A shared foundation of language change
Authors: Greenhill Simon J.
Published: July 2023

Short-term development and long-term evolution of language share mechanisms
Democracy Intercepted
Authors: Uzogara Ekeoma E.
Published: July 2023

Did platform feeds sow the seeds of deep divisions during the 2020 US presidential election?
PbIso: an R package and web app for calculating and plotting Pb isotope data
Authors: Armistead Sheree E. , Eglington Bruce M. , Pehrsson Sally J.
Published: July 2023

The package PbIso is a free and open R toolbox for commonly used calculations and plots of Pb–Pb isotope data and for generating Pb evolution models. In this paper, we review Pb isotope systematics and the calculations that are commonly used, such as model age, model source μ (238U/204Pb), time-integrated κ (232Th/238U), and initial Pb isotope ratios. These equations are implemented into R functions in the package PbIso. In addition, functions are provided for generating Pb evolution models, paleoisochrons, and isochrons. This allows users to apply calculations to their data in a straightforward way while providing transparency and flexibility of the calculations used. We have implemented some basic features of the PbIso package into an online shiny R application (see https://shereearmistead.github.io/software/pbiso ), which makes it easy for users without any R experience to use these calculations with their own data and to generate plots. We have provided a case study from the Superior Province in Canada, showing how different Pb evolution models can be generated in PbIso and compared to Pb isotope data.
Study on magnetostriction of ferromagnetic particles–superconducting matrix based on multi-chain model
Authors: Zhao Yufeng , Shi Jinheng
Published: July 2023

Based on the magnetic dipole theory and the elastic mechanical plane strain method, this paper establishes a multi-chain model of ferromagnetic particle inclusions–superconducting matrix and investigates the effects of the distribution form of ferromagnetic particle inclusions and elastic parameters on the effective magnetostriction of superconductors. A dimensionless parameter is introduced to describe the spatial distribution form of ferromagnetic particles in the matrix, and the calculation is carried out using the elastic mechanical plane strain method. The change of the effective magnetostriction following the elastic parameter is given for three kinds of distribution forms: single-chain, planar–laminar, and spatial three-dimensional multi-chain, respectively. The results show that the distribution of ferromagnetic particle inclusions and the change of elastic parameters have a notable influence on the displacement and magnetostrictive distribution of superconductors.
Sufficient Conditions of (Isolated) Toughness and Binding Number for the Existence of Component Factors
Authors: Ma Zhiqiang , Ren Fengyun , Wei Meiqin , Bao Gemaji
Published: July 2023

For a family of connected graphs [Formula: see text], a spanning subgraph [Formula: see text] of [Formula: see text] is called an [Formula: see text]-factor if each component of [Formula: see text] is isomorphic to a member of [Formula: see text]. In this paper, sufficient conditions with regard to tight toughness, isolated toughness and binding number bounds to guarantee the existence of the [Formula: see text]-factor, [Formula: see text]-factor or [Formula: see text]-factor for [Formula: see text] are obtained.
Novel High-Temperature Alkaline Water Electrolysis Using Molten KOH–H2O System
Authors: Kawaguchi Kenji , Goto Keita , Konno Aozora , Nohira Toshiyuki
Published: July 2023

To improve water electrolysis efficiency, we investigated the hydrogen and oxygen evolution reactions (HER and OER) at a Ni electrode in a molten KOH–H2O system (85:15 wt%, 65:35 mol%) at a high temperature (150 °C). The overpotentials for the HER and OER at 500 mA cm−2 were significantly reduced, by 261 mV and 75 mV, respectively, in the novel system relative to those obtained in a conventional aqueous solution system (30 wt% KOH, 80 °C). The decreases in polarization were attributed predominantly to kinetic effects, including a change in the rate-determining steps, on the HER and OER with the change of electrolytes.
Accidental Intraoperative Mandibular Fracture in a Third Molar Surgery: When Surgical Skills Are Mandatory in the Face of Empiricism
Authors: Pinho John Nadson Andrade , da Mota Santana Lucas Alves , de Souza Leandro Napier , Kumar Paulo Nand , Júnior Paulo Almeida , de Almeida Souza Liane Maciel
Published: July 2023

Iatrogenic mandible fractures are rare complications from third molar removal surgeries. While most documented cases stress risk factors inherent to the patient and tooth presentation in fractures’ etiology, appreciation of the risk factors underlying the practitioner’s skills is scarce. Here, we describe an intraoperative fracture in a healthy 26-year-old female resulting from an incompatible surgical technique during the right mandibular third molar removal. The patient showed facial swelling, pain, malocclusion, and significant mobility of the fractured segment. The surgical management involved an intraoral open reduction with the installation of titanium plates for the fixation of the bone segments. Thus, we highlight that acknowledging the extent of the operator’s surgical skills should be part of comprehensive treatment planning, serving as a valuable measure to prevent iatrogenic mandible fractures besides avoiding a traumatic experience for the patient.
A Nonlinear Three-Dimensional Finite Element Analysis of Stress Distribution and Microstrain Evaluation in Short Dental Implants with Three Different Implant–Abutment Connections in Single and Splinted Conditions in the Posterior Mandible
Authors: Talreja Karishma S. , Rodrigues Shobha J. , Pai Umesh Y. , Shetty Thilak , Saldanha Sharon , Mahesh M. , Hegde Puneeth , Shenoy Satish B. , Naik Nithesh , Mukherjee Sandipan , Sales Ann , Kamath Vignesh , Bajantri Prashant
Published: July 2023

Background. Stress distribution plays a vital role in the longevity and success of implant-supported prosthesis. This study evaluated the von Mises stress and microstrain in the peri-implant bone and the implant–abutment junction of short dental implants with three different implant–abutment connections in splinted and unsplinted conditions using finite element analysis (FEA). Materials and Methods. In this experimental study, nine transversely isotropic finite element models were developed, and randomly divided into three equal groups (n = 3): control, (Group AC) single-standard 4.3 × 10 mm bone level implant-supported restorations with external hexagonal (EH) connection, internal conical (IC) and internal trichannel (ITC) connection, single short implant-supported restorations (Group AT), and splinted short implant-supported restorations (Group B) for each of the three implant–abutment connections, respectively. A 200 N load was applied along the long axis of the implants and a 100 N (45°) oblique load was applied and von Mises stress and microstrain values were evaluated. Results. Single standard implants demonstrated the highest von Mises stress and microstrain values followed by single short implants and splinted short implants, respectively. Among the implant–abutment connections, the IC connection showed the highest values and the ITC connection showed the least values. Conclusion. Within the limitations of this study, it was concluded that splinting of short dental implants demonstrated lesser and more homogeneous stress and microstrain, especially on oblique loading. The microstrain values for all connections evaluated were within the physiological loading limit (200–2,500 N) and were hence considered safe for clinical use.
Table S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Authors: Kilian Michael , Friedrich Mirco , Sanghvi Khwab , Green Edward , Pusch Stefan , Kawauchi Daisuke , Löwer Martin , Sonner Jana K. , Krämer Christopher , Zaman Julia , Jung Stefanie , Breckwoldt Michael O. , Willimsky Gerald , Eichmüller Stefan B. , von Deimling Andreas , Wick Wolfgang , Sahm Felix , Platten Michael , Bunse Lukas
Published: July 2023

Table S1A. Peptides; Table S1B. NetMHCIIpan 4.0; Table S1C. NetMHC 4.0
Supplementary Figure S3 from Caveolin Gene Expression Predicts Clinical Outcomes for Early-Stage HER2-Negative Breast Cancer Treated with Paclitaxel-Based Chemotherapy in the GeparSepto Trial
Authors: Williams Terence M. , Schneeweiss Andreas , Jackisch Christian , Shen Changxian , Weber Karsten E. , Fasching Peter A. , Denkert Carsten , Furlanetto Jenny , Heinmöller Ernst , Schmatloch Sabine , Karn Thomas , Szeto Christopher W. , van Mackelenbergh Marion T. , Nekljudova Valentina , Stickeler Elmar , Soon-Shiong Patrick , Schem Christian , Mairinger Thomas , Müller Volkmar , Marme Frederik , Untch Michael , Loibl Sibylle
Published: July 2023

Supplementary Figure S3. CAV1 RNA expression is positively correlated with CAV1 protein expression in the TCGA invasive breast carcinoma database.
Supplementary Table S5 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

GeoMx ROI Information
Supplementary Table S4 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Patient Demographics
Supplementary Figure S7 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

FOV placement for SMI Analysis for Patients 7 and 8 showing variation between sampled regions of the tumor
Supplementary Figure S5 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Subasumstat dependent decrease in cell cycle signature observed across the tumor sample set by DSP
Supplementary Figure S18 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Correlation of MKI67 gene expression levels to Percent MIL113 Positivity for Tumors 7 and 8
Supplementary Figure S17 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Subasumstat-induced Interferon signature expression level is predicted by the CD8/CD68 ratio of the baseline tumor
Supplementary Figure S1 from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Subasumstat Target Engagement Grading by MIL113 Staining
Data from Caveolin gene expression predicts clinical outcomes for early-stage HER2-negative breast cancer treated with paclitaxel-based chemotherapy in the GeparSepto trial
Authors: Williams Terence M. , Schneeweiss Andreas , Jackisch Christian , Shen Changxian , Weber Karsten E. , Fasching Peter A. , Denkert Carsten , Furlanetto Jenny , Heinmöller Ernst , Schmatloch Sabine , Karn Thomas , Szeto Christopher W. , van Mackelenbergh Marion T. , Nekljudova Valentina , Stickeler Elmar , Soon-Shiong Patrick , Schem Christian , Mairinger Thomas , Müller Volkmar , Marme Frederik , Untch Michael , Loibl Sibylle
Published: July 2023

Abstract
Background: Caveolin-1 and -2 (CAV1/2) dysregulation are implicated in driving cancer progression and may predict response to nab-paclitaxel. We explored the prognostic and predictive potential of CAV1/2 expression for early-stage HER2-negative (HER-) breast cancer (BC) patients receiving neoadjuvant paclitaxel-based chemotherapy regimens. Patients and Methods: We correlated tumor CAV1/2 RNA expression with pathologic complete response (pCR), disease-free survival (DFS) and overall survival (OS) in the GeparSepto trial, which randomized patients to neoadjuvant paclitaxel- versus nab-paclitaxel-based chemotherapy. Results: RNA-Seq data was available for 279 patients, of which 74 (26.5%) were hormone receptor (HR)-negative, thus triple-negative BC (TNBC). Patients treated with nab-paclitaxel with high CAV1/2 had higher probability of obtaining a pCR (CAV1 odds ratio (OR) = 4.92, 95% CI 1.70-14.22, p=0.003; CAV2 OR=5.39, 95%CI 1.76-16.47, p=0.003) as compared to patients with high CAV1/2 treated with solvent-based paclitaxel (CAV1 OR=0.33, 95%CI 0.11-0.95, p=0.040; CAV2 OR=0.37, 95%CI 0.12-1.13, p=0.082). High CAV1 expression was significantly associated with worse DFS and OS in paclitaxel-treated patients (DFS HR=2.29, 95%CI 1.08-4.87, p=0.030; OS HR=4.97, 95%CI 1.73-14.31, p=0.003). High CAV2 was associated with worse DFS and OS in all patients (DFS HR=2.12, p=0.006; OS HR=2.51, p=0.013), in paclitaxel-treated patients (DFS HR=2.47, p=0.025; OS HR=4.24, p=0.007) and in patients with TNBC (DFS HR=4.68, p=0.009; OS HR=10.43, p=0.032). Conclusions: Our findings indicate high CAV1/2 expression is associated with worse DFS and OS in paclitaxel-treated patients. Conversely, in nab-paclitaxel-treated patients, high CAV1/2 expression is associated with increased pCR and no significant detriment to DFS or OS compared to low CAV1/2 expression.
Data from Caveolin Gene Expression Predicts Clinical Outcomes for Early-Stage HER2-Negative Breast Cancer Treated with Paclitaxel-Based Chemotherapy in the GeparSepto Trial
Authors: Williams Terence M. , Schneeweiss Andreas , Jackisch Christian , Shen Changxian , Weber Karsten E. , Fasching Peter A. , Denkert Carsten , Furlanetto Jenny , Heinmöller Ernst , Schmatloch Sabine , Karn Thomas , Szeto Christopher W. , van Mackelenbergh Marion T. , Nekljudova Valentina , Stickeler Elmar , Soon-Shiong Patrick , Schem Christian , Mairinger Thomas , Müller Volkmar , Marme Frederik , Untch Michael , Loibl Sibylle
Published: July 2023

AbstractBackground:
Caveolin-1 and -2 (CAV1/2) dysregulation are implicated in driving cancer progression and may predict response to nab-paclitaxel. We explored the prognostic and predictive potential of CAV1/2 expression for patients with early-stage HER2-negative breast cancer receiving neoadjuvant paclitaxel-based chemotherapy regimens, followed by epirubicin and cyclophosphamide.
Patients and Methods:
We correlated tumor CAV1/2 RNA expression with pathologic complete response (pCR), disease-free survival (DFS), and overall survival (OS) in the GeparSepto trial, which randomized patients to neoadjuvant paclitaxel- versus nab-paclitaxel–based chemotherapy.
Results:
RNA sequencing data were available for 279 patients, of which 74 (26.5%) were hormone receptor (HR)–negative, thus triple-negative breast cancer (TNBC). Patients treated with nab-paclitaxel with high CAV1/2 had higher probability of obtaining a pCR [CAV1 OR, 4.92; 95% confidence interval (CI), 1.70–14.22; P = 0.003; CAV2 OR, 5.39; 95% CI, 1.76–16.47; P = 0.003] as compared with patients with high CAV1/2 treated with solvent-based paclitaxel (CAV1 OR, 0.33; 95% CI, 0.11–0.95; P = 0.040; CAV2 OR, 0.37; 95% CI, 0.12–1.13; P = 0.082). High CAV1 expression was significantly associated with worse DFS and OS in paclitaxel-treated patients (DFS HR, 2.29; 95% CI, 1.08–4.87; P = 0.030; OS HR, 4.97; 95% CI, 1.73–14.31; P = 0.003). High CAV2 was associated with worse DFS and OS in all patients (DFS HR, 2.12; 95% CI, 1.23–3.63; P = 0.006; OS HR, 2.51; 95% CI, 1.22–5.17; P = 0.013), in paclitaxel-treated patients (DFS HR, 2.47; 95% CI, 1.12–5.43; P = 0.025; OS HR, 4.24; 95% CI, 1.48–12.09; P = 0.007) and in patients with TNBC (DFS HR, 4.68; 95% CI, 1.48–14.85; P = 0.009; OS HR, 10.43; 95% CI, 1.22–89.28; P = 0.032).
Conclusions:
Our findings indicate high CAV1/2 expression is associated with worse DFS and OS in paclitaxel-treated patients. Conversely, in nab-paclitaxel–treated patients, high CAV1/2 expression is associated with increased pCR and no significant detriment to DFS or OS compared with low CAV1/2 expression.
Supplementary Table S1 from FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer
Authors: Wilde Blake R. , Chakraborty Nishma , Matulionis Nedas , Hernandez Stephanie , Ueno Daiki , Gee Michayla E. , Esplin Edward D. , Ouyang Karen , Nykamp Keith , Shuch Brian , Christofk Heather R.
Published: July 2023

Supplementary Table S1: FH variants with population frequencies, interpretations of pathogenicity, catalytic efficiencies, and multimerization states
Supplementary Table 2 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
Authors: Yaeger Rona , Mezzadra Riccardo , Sinopoli Jenna , Bian Yu , Marasco Michelangelo , Kaplun Esther , Gao Yijun , Zhao HuiYong , Paula Arnaud Da Cruz , Zhu Yingjie , Perez Almudena Chaves , Chadalavada Kalyani , Tse Edison , Chowdhry Sudhir , Bowker Sydney , Chang Qing , Qeriqi Besnik , Weigelt Britta , Nanjangud Gouri J. , Berger Michael F. , Der-Torossian Hirak , Anderes Kenna , Socci Nicholas D. , Shia Jinru , Riely Gregory J. , Murciano-Goroff Yonina R. , Li Bob T. , Christensen James G. , Reis-Filho Jorge S. , Solit David B. , de Stanchina Elisa , Lowe Scott W. , Rosen Neal , Misale Sandra
Published: July 2023

Patients Progression Cell Free DNA data
Supplementary Table 1 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
Authors: Yaeger Rona , Mezzadra Riccardo , Sinopoli Jenna , Bian Yu , Marasco Michelangelo , Kaplun Esther , Gao Yijun , Zhao HuiYong , Paula Arnaud Da Cruz , Zhu Yingjie , Perez Almudena Chaves , Chadalavada Kalyani , Tse Edison , Chowdhry Sudhir , Bowker Sydney , Chang Qing , Qeriqi Besnik , Weigelt Britta , Nanjangud Gouri J. , Berger Michael F. , Der-Torossian Hirak , Anderes Kenna , Socci Nicholas D. , Shia Jinru , Riely Gregory J. , Murciano-Goroff Yonina R. , Li Bob T. , Christensen James G. , Reis-Filho Jorge S. , Solit David B. , de Stanchina Elisa , Lowe Scott W. , Rosen Neal , Misale Sandra
Published: July 2023

Patients Characteristics
Supplementary Figure 5 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
Authors: Yaeger Rona , Mezzadra Riccardo , Sinopoli Jenna , Bian Yu , Marasco Michelangelo , Kaplun Esther , Gao Yijun , Zhao HuiYong , Paula Arnaud Da Cruz , Zhu Yingjie , Perez Almudena Chaves , Chadalavada Kalyani , Tse Edison , Chowdhry Sudhir , Bowker Sydney , Chang Qing , Qeriqi Besnik , Weigelt Britta , Nanjangud Gouri J. , Berger Michael F. , Der-Torossian Hirak , Anderes Kenna , Socci Nicholas D. , Shia Jinru , Riely Gregory J. , Murciano-Goroff Yonina R. , Li Bob T. , Christensen James G. , Reis-Filho Jorge S. , Solit David B. , de Stanchina Elisa , Lowe Scott W. , Rosen Neal , Misale Sandra
Published: July 2023

Oncoprint of baseline alterations in CRC patients who developed resistance to KRAS G12C and EGFR inhibitors
Supplementary Figure 1 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
Authors: Yaeger Rona , Mezzadra Riccardo , Sinopoli Jenna , Bian Yu , Marasco Michelangelo , Kaplun Esther , Gao Yijun , Zhao HuiYong , Paula Arnaud Da Cruz , Zhu Yingjie , Perez Almudena Chaves , Chadalavada Kalyani , Tse Edison , Chowdhry Sudhir , Bowker Sydney , Chang Qing , Qeriqi Besnik , Weigelt Britta , Nanjangud Gouri J. , Berger Michael F. , Der-Torossian Hirak , Anderes Kenna , Socci Nicholas D. , Shia Jinru , Riely Gregory J. , Murciano-Goroff Yonina R. , Li Bob T. , Christensen James G. , Reis-Filho Jorge S. , Solit David B. , de Stanchina Elisa , Lowe Scott W. , Rosen Neal , Misale Sandra
Published: July 2023

Characterization of acquired resistance in vitro models
Supplementary Movie from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches
Authors: Nair Pramod C. , Piehler Jacob , Tvorogov Denis , Ross David M. , Lopez Angel F. , Gotlib Jason , Thomas Daniel
Published: July 2023

JAK2-PK
Supplementary File 2 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches
Authors: Nair Pramod C. , Piehler Jacob , Tvorogov Denis , Ross David M. , Lopez Angel F. , Gotlib Jason , Thomas Daniel
Published: July 2023

JAK2-monomer-500ns.pdb. (Structure of human JAK2 monomer at 500 ns simulation).
Supplementary Figure S1 from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches
Authors: Nair Pramod C. , Piehler Jacob , Tvorogov Denis , Ross David M. , Lopez Angel F. , Gotlib Jason , Thomas Daniel
Published: July 2023

Figure showing X-ray crystal structure of pseudokinase domain inhibitor
Figure S4 from HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: July 2023

TAp73 significance in HBZ pathogenesis and its effect on cellular metabolism.
Figure S2 from HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: July 2023

HBZ protein alters epigenetic regulation of TAp73 by EZH2.
Supplementary Table S4 from A pilot study of neoadjuvant nivolumab, ipilimumab and intralesional oncolytic virotherapy for HER2-negative breast cancer
Authors: Nguyen Vina P , Campbell Katie M. , Nowicki Theodore S , Elumalai Nila , Medina Egmidio , Baselga-Carretero Ignacio , DiNome Maggie L , Chang Helena R. , Oseguera Denise K , Ribas Antoni , Glaspy John A.
Published: July 2023

Biopsy samples for analyses
Supplementary Data from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
Authors: Pan Mengwu , Solozobova Valeria , Kuznik Nane C. , Jung Nicole , Gräßle Simone , Gourain Victor , Heneka Yvonne M. , Cramer von Clausbruch Christina A. , Fuhr Olaf , Munuganti Ravi S. N. , Maddalo Danilo , Blattner Christine , Neeb Antje , Sharp Adam , Cato Laura , Weiss Carsten , Jeselsohn Rinath M. , Orian-Rousseau Veronique , Bräse Stefan , Cato Andrew C. B.
Published: July 2023

Supplementary data and Supplementary figure legends.
Figure S3 from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
Authors: Pan Mengwu , Solozobova Valeria , Kuznik Nane C. , Jung Nicole , Gräßle Simone , Gourain Victor , Heneka Yvonne M. , Cramer von Clausbruch Christina A. , Fuhr Olaf , Munuganti Ravi S. N. , Maddalo Danilo , Blattner Christine , Neeb Antje , Sharp Adam , Cato Laura , Weiss Carsten , Jeselsohn Rinath M. , Orian-Rousseau Veronique , Bräse Stefan , Cato Andrew C. B.
Published: July 2023

X15695 alters the cellular localization of wild-type p53 but not mutant p53.
Figure S2 from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
Authors: Pan Mengwu , Solozobova Valeria , Kuznik Nane C. , Jung Nicole , Gräßle Simone , Gourain Victor , Heneka Yvonne M. , Cramer von Clausbruch Christina A. , Fuhr Olaf , Munuganti Ravi S. N. , Maddalo Danilo , Blattner Christine , Neeb Antje , Sharp Adam , Cato Laura , Weiss Carsten , Jeselsohn Rinath M. , Orian-Rousseau Veronique , Bräse Stefan , Cato Andrew C. B.
Published: July 2023

X15695-mediated attenuation of ERalpha target gene expression and reactivation of p53.