bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship Between Confirmed COVID-19 Positive Characteristics of Laboring Mothers and the Incidence of Asphyxia in Infants at Hospital Dr. Hasan Sadikin Bandung
Authors: Triyani Dinna , Yogi Pramatirta Akhmad , Aryuti Nirmala Sefita , Indra Susanti Ari , Dyah Bestari Astuti
Published: November 2024

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19). In December 2021, the Omicron variation was first identified in Indonesia, and it has since been linked to nearly 72 million cases worldwide. When COVID-19 is present during pregnancy, unfavorable outcomes including stillbirth, preterm delivery, and maternal mortality may occur. The purpose of this research was to examine the association between the features of women who tested positive for COVID-19 and the incidence of asphyxia in their babies at Dr. Hasan Sadikin General Hospital in Bandung between July 2021 and July 2022. A quantitative descriptive technique was used, and 69 mothers and 70 babies were sampled overall. Medical records provided the data, which was then subjected to chi-square analysis. There was no discernible correlation between the incidence of hypoxia and the mother's age (p = 0.838), parity (p = 0.647), or delivery method (p = 0.313). Nonetheless, a noteworthy correlation was seen between the gestational age (p = 0.001) and the maternal difficulties (p = 0.013) associated with baby hypoxia. This research found that whereas age, parity, and delivery style were not substantially linked with newborn hypoxia, gestational age and COVID-19-related problems were.
Revisioning the Soul of Medical Practice
Authors:   Franciscan Alliance Medical System Rensselaer IN, USA, Ungar-Sargon Julian
Published: November 2024

One of medicine’s great traditions is humanistic care of those
who are suffering [1-6]. Deep-seated personal commitment to
incorporate human values like caring, compassion, and respect
into every health care relationship defines medical humanism and
is imbedded within the fabric of medical professionalism [7-12].
Inhibitory and Stability Studies on Graphene Oxide Gold Nanozymes
Authors:   Hormozi Laboratory of Chemistry and Biochemistry, Iran, Hormozi Jangi Mohammad Reza , Hormozi Jangi Ali Reza ,   Hormozi Laboratory of Chemistry and Biochemistry, Iran
Published: November 2024

In this study, peroxidase-like graphene oxide/gold nanoparticles were synthesized and characterized for their biochemical stability
including pH and thermal stability by determining their relative activity as an index for their stability monitoring. Besides, the
inhibitory effect of metal ions on their enzyme like activity was also studied. The results of thermal stability studies revealed a
maximal activity over a wide temperature range of 20-40 ℃, revealing high thermal stability of the as-synthesized peroxidaselike graphene oxide/gold nanoparticles. The pH stability measurements revealed a maximal activity over pH= 4.5-5.5 for the
as-synthesized peroxidase-like graphene oxide/gold nanoparticles, showing their wide pH range. Moreover, the inhibitory effect
of silver ions (as a model metal ion) on their activity was checked at optimal pH and temperature, revealing that the activity of
nanozymes was decreased by increasing the concentration of silver ions and reached about 63% upon the addition small portion
of silver ions into the reaction media.
Psicoeducación comunitaria aprendiendo juntos: Descubriendo juntos -12 a 14 años
Authors:   Universidad del Azuay, Chocho-Orellana Ximena , Reyes-Fernández de Córdova Norma ,   Universidad del Azuay, Cordero-Cobos Lucía ,   Universidad del Azuay
Published: November 2024

En el umbral de este libro, nos embarcamos en una travesía por el fascinante mundo de la psicoeducación, diseñada para iluminar las mentes jóvenes y ser una brújula para padres y maestros en la noble tarea de guiar a niños y adolescentes. Este libro es un faro de conocimiento, cuyo propósito es desentrañar los misterios del desarrollo psicológico, emocional y vocacional, ofreciendo estrategias y herramientas prácticas que fomentan el bienestar y la resiliencia. A través de sus páginas, exploraremos cómo el entendimiento y la comprensión de uno mismo y de los demás pueden transformar la educación y la crianza en una experiencia enriquecedora y liberadora.
Este texto busca ser un compañero de viaje en la mencionada travesía de la educación, apoyar y animar a los padres y docentes en su camino. Con un lenguaje claro y comprensible, buscamos tender puentes entre la teoría y la práctica, entre la ciencia y la cotidianidad, para que cada concepto se con- vierta en una semilla de cambio positivo en la vida de los niños y jóvenes. Es una invitación a abrir los ojos al potencial ilimitado que reside en la mente en desarrollo de cada niño y joven, y a abrazar el poder de la educación consciente y la comunicación efectiva.
Que las enseñanzas de este libro sean lluvia fresca, gotas de agua y de rocío que favorezcan la fecundación y crecimiento de todos los esfuerzos y desvelos de padres y docentes, que siembran día a día en la mente y corazón de los niños y adolescentes. Seguro que llegará el día de la cosecha, el fabuloso día de la floración; mientras tanto este libro es un compañero de camino. Bienvenidos a un viaje de descubrimiento, crecimiento y esperanza, donde cada tema es un paso adelante en el camino hacia una comprensión más profunda y un futuro más brillante para nuestros niños y adolescentes.
90 páginas
ISBN: 978-9942-670-41-0
e-ISBN: 978-9942-670-42-7
Mediación pedagógica: Teoría y práctica en estudios de posgrado
Authors:   Universidad del Azuay, Guevara-Toledo Carlos Wilfrido , Prieto-Castillo Daniel ,   Universidad del Azuay, Célleri Gomezcoello Ambar ,   Universidad del Azuay
Published: November 2024

Mediación pedagógica. Teoría y práctica en estudios de posgrado” representa la culminación de un proceso de producción intelectual de los autores conformado por dos obras más: “Elogio de la tutoría. Una experiencia de promoción y acompañamiento del aprendizaje en el posgrado” y “Más allá de la defensa y el ataque. La evaluación como alternativa de aprendizaje”. A partir de la experiencia vivida en la Especialidad en Docencia Universitaria de la Universidad del Azuay, tal producción significa un aporte a la reflexión y la práctica de la pedagogía en la Universidad a nivel del pregrado y el posgrado, en el contexto de América Latina.
202 páginas
ISBN: 978-9942-670-35-9
e- ISBN: 978-9942-670-36-6
Ribânın Zinadan Daha Günah Olduğuna Dair Rivâyetlerin Tetkiki
Authors: Apaydın Mehmet
Published: November 2024

Hadis kaynaklarında ribânın yetmiş küsur şube olduğu; ribânın zina etmekten, hatta bir kimsenin annesiyle zina etmesi kadar büyük bir günah olduğuna dair Hz. Peygamber’e nispet edilen rivâyetler yer almaktadır. Bu rivâyetler ribâ ile zina arasındaki bağlantı yönüyle ve bir dirhem ribâ için dahi 30 küsur defa zina vebali olacağına dair abartılı gibi görünen içerikleri nedeniyle tenkide tabi tutulmuştur. Bu çalışmada söz konusu rivâyetlerin tetkiki yapılmış ve hadislerin kayıt altına alındığı erken dönemlerde noktalama işaretlerinin nadiren kullanılmasından dolayı zinâ (الزنا) olarak yazılan, fakat nokta konulmayan harflerin daha sonraları hatalı noktalanması (tashif) veya kıraat edilmesinden dolayı ribâ (الرِّبَا) şeklinde okundukları sonucuna ulaşılmıştır. Bu kelimenin erken döneme ait hadis kaynaklarının elimizdeki matbu nüshalarında (الربا) şeklinde noktalandığını, ancak el-Ḥeyŝemî gibi müteahhir alimlerin erken dönem eserlerden nakillerinde (الزنا) kaydedildiği görülmüştür. Bu tespitler çerçevesinde bu farklılığın ya müteahhir müstensihlerden ya da muhakkiklerden kaynaklandığı kanaatine varılmıştır. Bunun yanında kişinin annesiyle zina etmesi anlamına gelen “كَمَنْ أَتَى أُمَّهُ” veya “أَنْ يَنْكِحَ الرَّجُلُ أُمَّهُ” ifadelerinin de ribâ kelimesiyle irtibatlı bir şekilde yanlış aktarıldığı; fakat doğrusunun “رَجُلٌ هَجَا رَجُلاً... وَنَفَى رَجُلاً مِنْ أَبِيهِ وَزَنى بِأُمِّهِ” şeklinde olması gerektiği tespit edilmiştir. Metinde geçen “وَزَنّى بِأُمِّهِ” şeklindeki ifadenin, bir kimseye zina isnad etmek anlamında tefʿil babından şeddeli olarak okunması gerektiği görülmüştür Bu tashihlerden sonra Hz. Peygamber’e isnad edilen rivâyette aslında zinanın 70 küsur çeşidinin bulunduğunu ifade ettiği, bir kimsenin başkasının annesine zina isnadında bulunmasının bile zina gibi günah olduğu ve zinadan bir dirhem dahi kazanç elde etmenin 30 küsur defa zina etmek kadar büyük bir günaha denk geldiğini; insanların gizli kalması gereken kusurlarını yaymanın zinadan daha büyük bir vebal olduğunun vurgulandığı sonucuna ulaşılmıştır.
Spectral analysis of EEG coherence in Alzheimer s disease
Authors: Parra-Rodríguez M.A. , Calderón-González P.L. , Llibre-Rodríguez J.J. , Gutiérrez J.V.
Published: November 2024

INTRODUCTION In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. AIMs. To explore the functional alterations caused by Alzheimer’s disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. PATIENTS AND METHODS We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. RESULTS Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band. The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH. The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. CONCLUSIONS Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.
Attention and executive processes in neuropsychological rehabilitation of the visuospatial processes
Authors: Muñoz-Céspedes J.M. , Paúl-Lapedriza N. , Blázquez-Alisente J.L.
Published: November 2024

INTRODUCTION AND OBJECTIVE. Cognitive deficits following lesions in parieto-occipital areas tend to cause, among others, visuospatial and visuoperceptive alterations. The AIM of this article is to examine the influence of others possible deficit over its rehabilitation. DEVELOPMENT. We discuss several patients who present visuospatial impairment after different brain injuries, not only those affecting the areas typically involved in these deficits, such as parieto-occipital cortex. Rehabilitation was conducted on an individual basis in the brain injury unit of Beata Maria Ana hospital. Neuropsychological evaluation showed some difficulties not previously described together with these deficits, related to attention, working memory and executive functions, as well as topographic disorientation, lack of visuospatial coordination, distances perception disorders and difficulty to mentally rotate objects. The rehabilitation was AIMed not only at restoration but also compensation of visuospatial deficits, successfully achieved after treatment: patients were capable of returning to their daily activities, including their jobs. CONCLUSION. In-patients with visuospatial deficits, a compressive neuropsychological evaluation seem to be essential to define the influence of the other cognitive domains over the rehabilitation of visuospatial problems. In particular, the reinforcement of processes related to attention control and executive functions could very important, give their contribution to the learning of compensatory strategies and assuming that those functions pay key role in the organization and supervision demanded for perceptual skills.
Attention Process Training application within an intervention project on attentional processes in children with cancer
Authors: Castillo M.C. Fournier-Del , López-Luengo B. , Bernabeu-Verdú J. , Cañete-Nieto A. , Castel-Sánchez V. , Suárez-Rodríguez J.
Published: November 2024

INTRODUCTION Childhood cancer treatments have made a spectacular advance in recent years, obtaining survival rates of about 70%. These survival rates have permitted many children to reach adulthood, but also involve the appearance of previously unknown neurocognitive sequelae because of high mortality. DEVELOPMENT. Neuropsychological evaluation allows the detection of these deficits and the design of intervention. In children, rather than a loss of function there is a loss of the capacities that should develop in comparison with his/her peers. To obtain a base line to determine the affected and altered areas, it is equally vital to assess the acute and long-term effects so as to evaluate the success of the intervention program. Attention Process Training (APT) is an individualized application program of attentional exercises of varying complexity in sustained, selective, alternating and divided attention. This program combines methods and techniques of cerebral damage rehabilitation, as well as educational and clinical psychology. It is completed with a self-instruction training which is applied in situations of daily life. CONCLUSIONS Child cancer treatment continues to carry long-term neurocognitive sequelae. Neuropsychological evaluation is basic for its detection, allowing relevant information to be offered to parents and teachers, so as to facilitate design of individualized rehabilitation procedures. Attention training is basic for this type of population with generalized damage related to white matter, and forms part of a wider rehabilitation process that enhance the ecological validity of the program.
Non-neoplastic space-occupying lesions mimicking central nervous system tumors
Authors: Cardozo J.J. , Cardozo-Sosa D.P. , Fernández-Abreu M.C. , Arismendi-Morillo G.J.
Published: November 2024

OBJECTIVE. To establish the frequency and nature of space-occupying lesions of the central nervous system (CNS) that mimic neoplastic growths. PATIENTS AND METHODS We reviewed the clinical records, imaging and neuropathological studies of patients operated in different hospitals of Maracaibo, Venezuela during the period January 1 1996-July 31 2002. These patients had a pre-operative diagnosis of CNS tumor, and their definitive diagnosis was non-neoplastic disease. RESULTS The 33 cases of expansive, non-neoplastic growths represented 8% of 408 CNS lesions diagnosed during the study period. Approximately two thirds of the cases (63,36%) consisted of either inflammatory or vascular lesions, whereas the rest of the cases grouped miscellaneous conditions. CONCLUSIONS Even though it is not frequent that non-neoplastic lesions of the CNS mimic expansive growths of neoplastic nature, on occasions the clinical and neuroimaging features of both groups of entities are remarkably similar.
Neuropsychological evaluation of advanced dementia: are cognitive assessment psychometric instruments useful? A systematic review
Authors: Deví-Bastida J , Domínguez-Luque P , Jofre-Font S
Published: November 2024

Introduction: We speak of advanced dementia when all the cognitive functions show a generalized and important affectation. In the course of advanced dementia it will be necessary to assess the suitability of the use or not of psychometric instruments. Objective: To determine the utility of the psychometric instruments of cognitive assessment that determines the neuropsychological evaluation of advanced dementia. Through the research of studies of the databases PubMed, PsychInfo, MedLine and Cochrane. The searches combined terms of advanced dementia, cognitive evaluation and pshycometric tests. Ten studies were included in the research. Development: The ten selected studies show how different psychometric tests can be used for the cognitive evaluation of patients with advanced dementia: SIB, SIB-s, M-OSPD, SCIP, SMMSE, mTSI and SIRS. Five of the ten studied the usefulness of these tests in their original version, and the remaining five verified the validity and reliability of the abbreviated versions of some of these tests. Conclusions: There are few scales that meet the appropriate psychometric characteristics to be able to carry out a cognitive evaluation effectively taking into account the difficulty that this poses for a person with severe dementia, but the instruments mentioned overcome the main limitations of other tools by presenting no effect ceiling and minimal floor effect.
Validation of the Spanish version of the Charcot-Marie-Tooth disease Pediatric Scale (CMTPedS)
Authors: Pitarch-Castellano I , Argente-Escrig H , Frasquet M , Damià-Vidal M , Canet-Barrera A , Sevilla T , Burns J
Published: November 2024

Introduction and aims: The Charcot-Marie-Tooth Pediatric Scale (CMTPedS) is a validated and change-sensitive tool for assessing the severity of neuropathy in children and adolescents between 3 and 20 years of age. The aim of this article is to translate and validate a Spanish version of the CMTPedS in order to disseminate its use in Spanish-speaking countries. Materials and methods: The process used to translate the CMTPedS into Spanish was the reverse parallel translation method based on the principles of good practice for translation and the cultural adaptation process of the Food and Drug Administration Guidelines. A direct translation of the original source of the CMTPedS into Spanish was performed first and reviewed by experts in Charcot-Marie-Tooth (CMT) disease trained in the use of the CMTPedS tool. The Spanish version was then translated back into English by a linguist specialised in translation. Results: The preliminary Spanish version of the CMTPedS was evaluated in 18 children with CMT aged 6-20 years (mean: 13.27). The scale was well tolerated and easy for children to understand and easy for clinicians to apply. None of the patients had any difficulty completing the scale. Conclusions: The Spanish version of the CMTPedS can be used for monitoring and conducting clinical trials in the Spanish population and in Spanish-speaking countries.
COVID-19 and herpesvirus encephalitis
Authors: Ramírez-Colombres M , Maenza C E , Rocchetti N S , Gattino S P , Diodati S , Luchitta C A , Ré M D , Settecase C J , Bagilet D H
Published: November 2024

Introduction: The SARS-CoV-2 virus, which causes COVID-19, could give rise to damage the nervous system. Many studies have been conducted on this topic, but few have focused specifically on encephalitis. The effect of SARS-CoV-2 on the clinical expression of other neurotropic viruses, such as Herpesviridae, is unknown. Case reports: We describe the cases of two young men (39 and 18 years old) in whom SARS-CoV-2 had been detected -reverse transcription polymerase chain reaction (RT-PCR)-, and with a clinical diagnosis and cerebrospinal fluid (CSF) analysis consistent with encephalitis. The first patient had a positive PCR for varicella zoster virus in CSF, while the second had a positive PCR for herpes simplex virus types 1 and 2. The first patient, who was recently diagnosed with human immunodeficiency virus, presented with fever, headache, vomiting, cough, inappropriate behaviour and epileptic seizures; the second was seen to have fever, headache, myalgia and exanthema. Both offered the same laboratory findings (lymphopenia and high interleukin 6). CSF showed pleocytosis with a predominance of monomorphonuclear cells, hyperproteinorrachia and normal glycorrhachia. A cranial CT scan showed only mild diffuse cerebral oedema in the first case. Both cases were treated with corticosteroids, antibiotics and acyclovir. The second progressed favourably, while the first did not. Conclusions: Little is known about co-infection of SARS-CoV-2 with neurotropic viruses, such as Herpesviridae, and we have only limited evidence of direct neurological involvement of SARS-CoV-2, due to the technical difficulty of detecting it in the nervous system, thus making it important to take co-infection into account in order to be able to establish an early diagnosis and treatment to improve prognosis.
Characteristics of patients with drug-resistant epilepsy in a tertiary hospital
Authors: Iglesias-Rodríguez M , Navarro-Abia V , Barbadillo-Mariscal B , Gil-Calderón F J , Gonzalo-San Esteban A , Mañaricua-Arnaiz A , Tejero-Pastor L , Conejo-Moreno D
Published: November 2024

Introduction: Drug-resistant epilepsy has a cumulative incidence between 14 and 20% of patients with epilepsy. It is associated with more comorbidities and with higher healthcare expenditure and impact on quality of life. Patients and methods: A retrospective longitudinal descriptive study was performed covering the period from 01/01/2010 to 02/28/2024. All patients with epilepsy seen in the Pediatric Neurology unit of our center were collected and a review of medical records was carried out to collect the characteristics and evolution during the study period. The classification and definitions used were those established by the International League Against Epilepsy. Results: A total of 325 patients with epilepsy were identified, with a cumulative incidence of DRE of 29%. The most frequent etiology was structural both in all patients with epilepsy (22%), and in drug-resistant epilepsy (36%). A statistically significant association was established between refractoriness and genetic and structural causes, and between having status epilepticus and the development of drug-resistant epilepsy. Seventy-nine percent of patients with drug-resistant epilepsy developed epileptic encephalopathy. The most commonly used antiseizure drug was valproic acid (90%), 19% received a ketogenic diet and 4.2% received epilepsy surgery. Conclusions: In our setting the incidence of drug-resistant epilepsy is high, more so than previously described. Genetic and structural etiologies are associated with a higher incidence. Having suffered status epilepticus is associated with refractoriness. A higher incidence was observed in patients with defined electroclinical syndromes, probably influenced by epileptic and developmental encephalopathies.
Resisting the Myth of Hobson’s Pledge and Crown Benevolence: Repairing the Record as Part of Weaving Together a Legal Future
Authors: Quince Khylee
Published: November 2024

On the 6 February 1840 at the first signings of the Tiriti o Waitangi between Māori and the British Crown, the pledge ‘he iwi tahi tātou’ ‘together we are a nation’ was attributed to Crown representative Lieutenant Governor William Hobson. That was allegedly corrected at the time by prominent chief Hone Heke, who noted that a more appropriate phrasing was ‘he iwi kotahi tātou’ – or ‘together we are one nation’, which implies a very different bargain underpinned by pluralism. Whether this happened or not, it conveniently established a mythology of Crown/Māori relations that has permeated our national consciousness and legal orderings, with Hobson’s pledge held up as a unifying mantra for people from ‘two worlds with one law’. That mythology embedded the assumption of Crown benevolence toward Māori – that the colonisers brought law, order and civilisation where there had been none.

This mythology denies the existence of Māori law and Māori agency in creating legal relationships with others, including early settlers. Ngāpuhi chief Patuone’s engagement in trade in the fledgling colony of New South Wales illustrates Māori concepts and practices of sovereignty and laws of obligations. It is also a deliberate mis-remembering of Māori resistance and the consistent assertion of Māori voice in both engaging with and rejecting settler law.

Contemporary politics and jurisprudence wrestle with understanding our history as part of the weaving together of our legal future in Aotearoa. Reckoning with that past requires repairing the record, and recognising the existence and operation of Māori law. A number of recent developments are providing hope in this space – including decolonisation and indigenisation of legal education.
Wai 262 Response: A Whole-of-Government Approach?
Authors: Houghton Jayden
Published: November 2024

In 1991, six Māori claimant groups sought the Waitangi Tribunal’s findings that the Crown had breached its Treaty of Waitangi guarantee to allow Māori to exercise tino rangatiratanga (the unqualified exercise of our chieftainship) over our mātauranga Māori (the body of knowledge originating from Māori ancestors, including the Māori worldview and cultural practices) and taonga (tangible and intangible treasures). In 2011, the Tribunal publicly released its full report on the claim. Since then, the New Zealand Government has been working out its response, internally at first and publicly since announcing Te Pae Tawhiti (a work programme to address the Crown’s breaches) in 2019. Māori have repeatedly asked that the Government’s response take a whole-of-government approach. This article demonstrates that the current response falls short of a whole-of-government approach and reiterates that a whole-of-government approach is required to appropriately address the scale of the impact of Wai 262 on governance in New Zealand. The article then provides guidance for the Government to learn from its own experience, as well as international experiences, with whole-of-government approaches, to develop a whole-of-government response that enables it to adequately respond to Wai 262. The article considers why a whole-of-government response is necessary, surveys the work the Government has done to make its response whole-of-government and identifies issues with the Government’s approach, before using scholarship and case studies in Australia and Hong Kong to urge the New Zealand Government to reconsider its approach to whole-of-government responses generally. The article contributes to the literature by presenting findings from Official Information Act requests in 2018, 2020 and 2022 to seven Te Pae Tawhiti-engaged Government agencies and interrogating the concept of a whole-of-government response in the New Zealand context. The insights will help Māori and others to hold the Government accountable as the Treaty partners progress Te Pae Tawhiti.
The potential for emojis to facilitate communication between patients and healthcare professionals: results from a digital survey and qualitative interviews
Authors: Essex Margaret Noyes , Blakeman Karin Hygge , Dietrich Caroline E. , Arnheim-Dahlström Lisen
Published: November 2024

Introduction

Effective communication is essential for building a successful patient–healthcare professional (HCP) relationship. Understanding a patient’s emotional context is key to building this relationship. However, communication barriers often hinder the development of these relationships. Strategies to communicate emotions in healthcare settings may address this issue. Emojis are small images that together form a universal language well-suited to describe emotions.

Methods

This three-phase feasibility study used quantitative and qualitative approaches to explore current opinions around the utility of emojis in expressing emotions during patient–HCP communications. In phase 1, members of the War on Cancer digital community participated in an online survey to determine their use of emojis in personal and healthcare communications. In phase 2, selected patient volunteers were interviewed to further understand the responses from the survey. In phase 3, invited HCPs were interviewed to evaluate their use of digital communications and emojis with patients, and insights on the findings from phases 1 and 2.

Results

In phase 1, 290 community members responded to the survey (16–84 years old; twenty-two countries). Of these, 70% (n = 197/280) reported common use of emojis in personal conversations, and 62% (n = 158/256) were optimistic about their use in HCP communications. All eight patients interviewed in phase 2 (30–70 years old; three countries) used emojis in personal communications but rarely in healthcare settings. They identified four situations where emojis could be useful in HCP communication: emotional preparation before a visit, follow-up after a visit, situations with a language barrier, and to replace numeric scales when expressing strength of emotion. All five of the HCPs interviewed in phase 3 (30–45 years old; two countries) communicated digitally with patients through electronic medical records or other platforms, but none had used emojis with patients. HCPs agreed with the four scenarios identified by patients in phase 2, further suggesting that emojis may be helpful for patients with poor literacy or difficulty expressing emotions.

Conclusion

In this study, patients and HCPs agreed that emojis could potentially enhance patient–HCP communication by facilitating emotional expression. Further research is required to evaluate the practicalities and benefits of integrating emojis into healthcare communications.
The media literacy dilemma: can ChatGPT facilitate the discernment of online health misinformation?
Authors: Peng Wei , Meng Jingbo , Ling Tsai-Wei
Published: November 2024

Online health misinformation carries serious social and public health implications. A growing prevalence of sophisticated online health misinformation employs advanced persuasive tactics, making misinformation discernment progressively more challenging. Enhancing media literacy is a key approach to improving the ability to discern misinformation. The objective of the current study was to examine the feasibility of using generative AI to dissect persuasive tactics as a media literacy scaffolding tool to facilitate online health misinformation discernment. In a mixed 3 (media literacy tool: control vs. National Library of Medicine [NLM] checklist vs. ChatGPT tool) × 2 (information type: true information vs. misinformation) × 2 (information evaluation difficulty: hard vs. easy) online experiment, we found that using dissecting persuasive strategies of ChatGPT can be equally effective when compared with the NLM checklist, and that information type was a significant moderator such that the ChatGPT tool was more effective in helping people identify true information than misinformation. However, the ChatGPT tool performed worse than control in terms of helping people discern misinformation. No difference was found in terms of perceived usefulness and future use intention of the ChatGPT tool and the NLM checklist. The results suggest that more interactive or conversational features might enhance usefulness of ChatGPT as a media literacy tool.
Identification of key genes in gout and atherosclerosis and construction of molecular regulatory networks
Authors: Qing Gong , Yuan Zujun
Published: November 2024

Background

Gout is a type of chronic inflammatory disease linked to the accumulation of monosodium urate crystals, leading to arthritis. Studies have shown that patients with gout are more likely to develop atherosclerosis, but the specific mechanisms involved remain unknown. The purpose of the research was to explore the key molecules and potential mechanisms between gout and atherosclerosis.

Methods

Gene expression profiles for gout as well as atherosclerosis were obtained from the Gene Expression Omnibus (GEO) database, then differential analysis was utilized to identify common differentially expressed genes (DEGs) between the two diseases. The analysis of functional enrichment was conducted to investigate the biological processes that the DEGs might be involved in. The Cytoscape software was utilized to develop a protein–protein interaction (PPI) network as well as identify hub genes, while LASSO analysis was employed to select key genes. The TRRUST database was utilized to forecast transcription factors (TFs), and the miRTarBase database was utilized to forecast miRNAs.

Results

Four key genes, CCL3, TNF, CCR2, and CCR5, were identified. The receiver operating characteristic (ROC) curves showed that the areas under ROC curve (AUC) for these four key genes in both gout and atherosclerosis were greater than 0.9. The analysis of functional enrichment revealed that the DEGs were primarily involved in “regulation of T-cell activation”, “chemokine signaling pathway”, and other biological processes. The TRRUST prediction results indicated that RELA and NFKB1 are common regulatory transcription factors for CCR2, CCR5, CCL3, and TNF. The miRTarBase prediction results showed that hsa-miR-203a-3p is a common regulatory miRNA for TNF and CCR5.

Conclusion

This study preliminarily explored the potential key molecules and mechanisms between gout and atherosclerosis. These findings provide new insights for further research into identifying potential biomarkers and clinical treatment strategies for these two diseases.
Immersive poetry learning: a field study with middle school students
Authors: Reynaert Vincent , Possik Jalal , Demarey Catherine , Kieken Danny , Abert Benoit , De Witte Benjamin
Published: November 2024

Introduction

The field of poetry learning is currently facing significant challenges, primarily due to a lack of motivation and interest among students. This has resulted in educators encountering difficulties in identifying suitable educational alternatives. To address the latter issue, immersive learning has emerged as a potential solution, as it has been demonstrated to enhance motivation and learning outcomes in a multitude of fields.

Methods

In light of the aforementioned considerations, this field study seeks to examine the potential of virtual reality (VR) tools in enhancing the memorization of poetry by increasing the engagement of the participants. The study concentrated on the acquisition of a French poem by a group of middle school students. A virtual environment has been developed for this purpose, tailored to the poem in question. The experimental design included a pretest, segmented learning sessions, a posttest, and a retention test. To evaluate student engagement, both motivation and sense of presence were measured using Likert-scale questionnaires, while memorization performance was assessed through a scoring system based on recall accuracy.

Results

The findings reveal that the VR group demonstrated significantly higher motivation than the control group, with a mean difference of 12.626 on a 7-point Likert scale (six items), indicating that VR is a notably more effective tool for enhancing motivation in poetry learning than traditional methods. Additionally, the VR group reported a significantly stronger sense of presence, with a mean difference of 6.111 on the same questionnaire scale, further suggesting that VR enhances students’ sense of immersion in the learning experience. These results indicate that students using VR exhibited higher levels of overall engagement than those in the control group.

Discussion

However, this increased engagement did not lead to improved memorization outcomes, as there was no significant difference in recall accuracy between the two groups. A potential explanation for this discrepancy is the “novelty effect” of VR, which may have distracted students from focusing fully on the memorization task. The implications of integrating VR in educational settings are thus discussed.
Case Report: Novel CNGA3 compound heterozygous variants cause achromatopsia in three patients from a family
Authors: Zhou Xiaoqiang , Zhou Yasi , Wu Shuijuan , Guo Xiaoling , Yao Liangfeng , Yang Xingkun
Published: November 2024

This study report a novel missense variant in the cyclic nucleotide-gated channel 3 (CNGA3) gene identified by targeted gene panel sequencing approach in a Chinese family with achromatopsia. The proband, a 24-year-old female, with normal intelligence, motor development and speech abilities exhibited nystagmus, amblyopia, photophobia, and indistinguishable colors. In addition, the two sisters of the proband had the same clinical symptoms, which means that three patients from a family with a monochromasia clinical diagnosis. Based on the family situation, the proband came to our hospital for facilitate genetic counseling. Genetic analysis using targeted gene panel sequencing was conducted to confirm causative variants. Compound heterozygous variants, including the novel missense c.524T>A (p.Ile175Asn) and the know missense variant c.829C>T (p.Arg277Cys), were identified in CNGA3. These variants represent the genetic defects associated with achromatopsia in this family.
Genewise detection of variants in MEFV gene using nanopore sequencing
Authors: Ghukasyan Lilit , Khachatryan Gisane , Sirunyan Tamara , Minasyan Arpine , Hakobyan Siras , Chavushyan Andranik , Hayrapetyan Varduhi , Ghazaryan Hovsep , Martirosyan Gevorg , Mkrtchyan Gohar , Vardanyan Valentina , Mukuchyan Vahan , Davidyants Ashot , Zakharyan Roksana , Arakelyan Arsen
Published: November 2024

Familial Mediterranean Fever (FMF) is a genetic disorder with complex inheritance patterns and genotype-phenotype associations, and it is highly prevalent in Armenia. FMF typically follows an autosomal recessive inheritance pattern (OMIM: 249100), though it can occasionally display a rare dominant inheritance pattern with variable penetrance (OMIM։134610). The disease is caused by mutations in the MEFV gene, which encodes the pyrin protein. While the 26 most prevalent mutations account for nearly 99% of all FMF cases, more than 60 pathogenic mutations have been identified. In this study, we aimed to develop an affordable nanopore sequencing method for full-length MEFV gene mutation detection to aid in the diagnosis and screening of FMF. We employed a multiplex amplicon sequencing approach, allowing for the processing of up to 12 samples on both Flow cells and Flongle flow cells. The results demonstrated near-complete concordance between nanopore variant calling and qPCR genotypes. Moreover, nanopore sequencing identified additional variants, which were confirmed by whole exome sequencing. Additionally, intronic and UTR variants were detected. Our findings demonstrate the feasibility of full-gene nanopore sequencing for detecting FMF-associated pathogenic variants. The method is cost-effective, with costs comparable to those of the qPCR test, making it particularly suitable for settings with limited laboratory infrastructure. Further clinical validation using larger sample cohorts will be necessary.
Correlating gene expression levels with transcription factor binding sites facilitates identification of key transcription factors from transcriptome data
Authors: Huang Tinghua , Niu Siqi , Zhang Fanghong , Wang Binyu , Wang Jianwu , Liu Guoping , Yao Min
Published: November 2024

Identification of key transcription factors from transcriptome data by correlating gene expression levels with transcription factor binding sites is important for transcriptome data analysis. In a typical scenario, we always set a threshold to filter the top ranked differentially expressed genes and top ranked transcription factor binding sites. However, correlation analysis of filtered data can often result in spurious correlations. In this study, we tested four methods for creating the gene expression inputs (ranked gene list) in the correlation analysis: star coordinate map transformation (START), expression differential score (ED), preferential expression measure (PEM), and the specificity measure (SPM). Then, Kendall’s tau correlation statistical algorithms implementing the standard (STD), LINEAR, MIX-LINEAR, DENSITY-CURVE, and MIXED-DENSITY-CURVE weighting methods were used to identify key transcription factors. ED was identified as the optimal method for creating a ranked gene list from filtered expression data, which can address the “unable to detect negative correlation” fallacy presented by other methods. The MIXED-DENSITY-CURVE was the most sensitive for identifying transcription factors from the gene set and list in which only the top proportion was correlated. Ultimately, 644 transcription factor candidates were identified from the transcriptome data of 1,206 cell lines, six of which were validated by wet lab experiments. The Jinzer and Flaver software implementing these methods can be obtained from http://www.thua45/cn/flaver under a free academic license.
Exploring micronutrients and microbiome synergy: pioneering new paths in cancer therapy
Authors: Bhatnagar Kartik , Jha Kanupriya , Dalal Nishu , Patki Ninad , Gupta Garima , Kumar Amit , Kumar Anil , Chaudhary Sarika
Published: November 2024

The human microbiome is the complex ecosystem consisting of trillions of microorganisms that play a key role in developing the immune system and nutrient metabolism. Alterations in the gut microbiome have been linked to cancer initiation, progression, metastasis, and response to treatment. Accumulating evidence suggests that levels of vitamins and minerals influence the gut environment and may have implications for cancer risk and progression. Bifidobacterium has been reported to reduce the colorectal cancer risk by binding to free iron. Additionally, zinc ions have been shown to activate the immune cells and enhance the effectiveness of immunotherapy. Higher selenium levels have been associated with a reduced risk of several cancers, including colorectal cancer. In contrast, enhanced copper uptake has been implicated in promoting cancer progression, including colon cancer. The interaction between cancer and gut bacteria, as well as dysbiosis impact has been studied in animal models. The interplay between prebiotics, probiotics, synbiotics, postbiotics and gut bacteria in cancer offers the diverse physiological benefits. We also explored the particular probiotic formulations like VSL#3, Prohep, Lactobacillus rhamnosus GG (LGG), etc., for their ability to modulate immune responses and reduce tumor burden in preclinical models. Targeting the gut microbiome through antibiotics, bacteriophage, microbiome transplantation-based therapies will offer a new perspective in cancer research. Hence, to understand this interplay, we outline the importance of micronutrients with an emphasis on the immunomodulatory function of the microbiome and highlight the microbiome’s potential as a target for precision medicine in cancer treatment.
The relationship between SIRT1 and inflammation: a systematic review and meta-analysis
Authors: Sun Haiyang , Li Dong , Wei Chaojie , Liu Liping , Xin Zhuoyuan , Gao Hang , Gao Rong
Published: November 2024

Recent studies underscore the anti-inflammatory role of SIRT1; however, its levels during inflammatory states remain ambiguous. We synthesized relevant studies up to 20 March 2024 to evaluate the relationship between SIRT1 and inflammation, using data from three major databases. Employing a random-effects model, we analyzed both cross-sectional and longitudinal studies, calculating weighted mean differences (WMDs) for pooled effect sizes. Subgroup and sensitivity analyses, along with a risk of bias assessment, were also conducted. We reviewed 13 publications, encompassing 21 datasets and 2,028 participants. The meta-analysis indicated higher SIRT1 levels in inflammatory groups compared to control groups pre-adjustment (WMD, 3.18 ng/ml; 95% CI 2.30, 4.06 ng/ml; P<0.001; I²= 99.7%) and post-adjustment (WMD, 0.88 ng/ml; 95% CI 0.14, 1.62 ng/ml; P<0.001; I²= 99.5%). Notably, middle-aged patients with inflammation exhibited lower SIRT1 levels (WMD, −0.85 ng/ml; 95% CI −1.47, −0.22 ng/ml; P= 0.008; I²= 95.4%), while groups characterized by East Asian descent, plasma studies, autoimmune conditions, and musculoskeletal disorders showed higher levels. The findings suggest that inflammation generally upregulates SIRT1, potentially elucidating its role in immunobiological processes. However, the significant heterogeneity observed, partly due to the cross-sectional nature of some data, limits insights into the duration of disease progression, which remains highly variable.
Case report: A cyclic neutropenia patient with ELANE mutation accompanied by hemophagocytic lymphohistiocytosis
Authors: Yu Lang , Li Yulin , Li Wenhui , Zhang Yishi , He Wenli , Tang Xuemei , An Yunfei , Zhao Xiaodong
Published: November 2024

Many inborn errors of immunity may accompany secondary hemophagocytic lymphohistiocytosis (HLH), a condition typically characterized by impaired cytotoxic T and NK cell function. A considerable proportion of HLH cases also stem from chronic granulomatosis with phagocytic dysfunction. However, the development of secondary HLH in patients with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) with abnormal phagocytic cell counts has been less frequently reported. Herein, we present a case of a pediatric patient with ELANE mutation-associated CyN who developed HLH subsequent to severe bacterial, fungal, and viral infections. Notable observations included impaired NK cell degranulation function (CD107a). To the best of our knowledge, this represents the first documented instance of HLH in patients with CyN attributed to an ELANE mutation. Thus, our study establishes a link between ELANE-related CyN and HLH, underscoring the importance of considering HLH as a potential complication in these patients.
Fibroblast growth factor receptor risk signature predicts patient prognosis and immunotherapy resistance in colorectal cancer
Authors: Li Xiaofang , Pan Zhiling , Luan Tiankuo , Xiao Qian , Li Liuying , Wu Qianxue , Yao Guoqing , Zhang Xiang , Song Daqiang
Published: November 2024

Background

Fibroblast Growth Factor Receptor (FGFR) signaling is linked with tumor progression and tumor immunoevasion, yet the potential effect of FGFR signature on the prognosis of patient with colorectal cancer (CRC) and response to immune therapy remains elusive.

Methods

The fibroblast growth factor receptor risk signature (FRS) was identified through single-cell RNA sequencing, bulk RNA sequencing, and machine learning techniques. Signaling enrichment analyses were conducted using Gene Set Enrichment Analysis (GSEA) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Drugs targeting the FRS were predicted using the Cancer Therapeutics Response Portal (CTRP) and PRISM databases. The analysis of T cell function and the tumor microenvironment (TME) was performed using flow cytometry.

Results

In this study, we characterized the FRS in cancer patients with CRC. By integrating advanced techniques, we identified the FRS and revealed the intricate molecular landscape and diversity of the FRS within the TME. Notably, the FRS effectively predicted unfavorable prognosis and resistance to immunotherapy in CRC patients. Furthermore, PHA-793887, identified as a potential FRS inhibitor by the CTRP and PRISM databases, significantly restructured the immunosuppressive TME and enhanced the antitumor immune response, resulting in a reduced tumor burden in the MC38 murine tumor model.

Conclusion

Together, these data support FRS positively correlates with poor prognosis and therapy resistance. The PHA-793887 could be a potential FRS inhibitor to improving the effectiveness of CRC management via bolstering antitumor immunity.
Case report: Spontaneous arterial bleeding in the lateral thoracic region during helmet CPAP treatment: a report of three cases in patients with severe COVID-19
Authors: Tripodi Vincenzo Francesco , Sardo Salvatore , Silipigni Salvatore , Stagno Alberto , Neri Antonio Francesco , Bottari Antonio , Mazzeo Anna Teresa
Published: November 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has put enormous pressure on healthcare systems worldwide. While the majority of severe cases present with respiratory failure, thrombosis or bleeding have also been reported at unusual sites. Major bleeding, particularly in patients treated with therapeutic anticoagulation, has been observed between the second and third week after the onset of SARS-CoV-2 infection. This article describes three cases of patients admitted to the hospital with severe SARS-CoV-2 pneumonia who had spontaneous arterial bleeding from the thoracic and subscapular regions during treatment with helmet continuous positive airway pressure (H-CPAP) in the intensive care unit (ICU), requiring a percutaneous embolization procedure. A possible correlation with helmet-supported ventilation is hypothesized.