bluuebunny/crossref_metadata_2025 huggingface dataset:
SCALABLE PHOTOGRAMMETRIC MOTION CAPTURE SYSTEM “MOSCA”: DEVELOPMENT AND APPLICATION
Authors: Knyaz V. A.
Published: May 2015

Abstract. Wide variety of applications (from industrial to entertainment) has a need for reliable and accurate 3D information about motion of an object and its parts. Very often the process of movement is rather fast as in cases of vehicle movement, sport biomechanics, animation of cartoon characters. Motion capture systems based on different physical principles are used for these purposes. The great potential for obtaining high accuracy and high degree of automation has vision-based system due to progress in image processing and analysis. Scalable inexpensive motion capture system is developed as a convenient and flexible tool for solving various tasks requiring 3D motion analysis. It is based on photogrammetric techniques of 3D measurements and provides high speed image acquisition, high accuracy of 3D measurements and highly automated processing of captured data. Depending on the application the system can be easily modified for different working areas from 100 mm to 10 m. The developed motion capture system uses from 2 to 4 technical vision cameras for video sequences of object motion acquisition. All cameras work in synchronization mode at frame rate up to 100 frames per second under the control of personal computer providing the possibility for accurate calculation of 3D coordinates of interest points. The system was used for a set of different applications fields and demonstrated high accuracy and high level of automation.
RECOGNITION OF SINGLE AND OVERLAY OF OBJECTS ON A CONVEYOR BELT
Authors: Savicheva S. V.
Published: May 2015

Abstract. Proposed a method for detection of flat objects when they overlap condition. The method is based on two separate recognition algorithms flat objects. The first algorithm is based on a binary image of the signature of the object plane. The second algorithm is based on the values of the discrete points in the curvature contour of a binary image. The results of experimental studies of algorithms and a method of recognition of individual superimposed flat objects.
A complexidade do fluxo da informação tecnológica e a interação da rede interna no subsidio ao desenvolvimento de produtos biotecnológicos
Authors: Inomata Danielly Oliveira , Rados Gregório Jean Varvakis
Published: May 2015

Objetivo. Aborda a complexidade do fluxo da informação como um processo dinâmico e contínuo, observando que existe uma intercâmbio entre os atores da organização formando uma rede interna de interação, cujas atividades e operações direcionam o fluxo de informação na organização. Método. Descreve os elementos e aspectos influentes do fluxo da informação tecnológica que fomentam o desenvolvimento de produtos biotecnológicos num centro de tecnologia e pesquisa, alocado na cidade de Manaus, no Estado do Amazonas. Resultados. Discute a troca de informação entre os pesquisadores e os colaboradores enredados na construção da informação com vistas à inovação de produtos, e no compartilhamento do conhecimento. Conclusões. Conclui que o estudo do fluxo da informação deve permitir a agregação da informação útil para o desenvolvimento dos produtos; as barreiras são capazes de paralisar o processo informacional, acarretando na dificuldade em atender os prazos dos projetos; os atores da rede interna de relações trabalham em sinergia, permitindo o compartilhamento de informações.
Normative Data for Macular Volume with High-Definition Spectral-Domain Optical Coherence Tomography (Spectralis)
Authors: Murthy Ravi K. , Diaz Michelle , Chalam Kakarla V. , Grover Sandeep
Published: May 2015

Purpose

To establish normative data for macular volume by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease.

Methods

In an academic institutional setting, 50 subjects (age range 20–84 years) with no known retinal disease, best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. The subjects were divided into 3 age groups: group 1 included subjects 20–40 years of age, group 2 included subjects 41–60 years of age, and group 3 included subjects 61 years of age and older. All subjects underwent a complete ophthalmologic examination and testing, if needed, to rule out any retinal diseases or glaucoma. Retinal volume (RV) in 9 Early Treatment Diabetic Retinopathy Study (ETDRS) subfields and total macular volume (TMV) inclusive of all 9 subfields were analyzed. Statistical analyses were carried out using analysis of variance.

Results

Overall, the mean TMV ± SD for ETDRS circles with a diameter of 1, 2.22, and 3.45 mm was determined to be 3.04 ± 0.14 mm3. Among the ETDRS subfields, RV was highest in the nasal outer field, with a mean of 0.47 ± 0.02 mm3. The TMV did not show a significant difference with age (p = 0.17). However, TMV was significantly higher in males (p = 0.003) and in Caucasian and Asian subjects compared to African Americans (p = 0.017).

Conclusions

Normative values for total macular volume in ETDRS subfields in otherwise healthy eyes were measured to be 3.04 ± 0.14 mm3.
Low Wear, High Stability - Promises of Success in a Moderately Cross-Linked Cup?
Authors: Flatøy Bernhard , Rydinge Jonas , Dahl Jon , Röhrl Stephan M. , Nordsletten Lars
Published: May 2015

Purpose

Cross-linking has proven effective in reducing polyethylene wear in total hip replacements. However, increasing the amount of cross-links will impair other mechanical properties of the polyethylene. The optimal threshold of crosslinking has still not been established. This led to the development of a moderately cross-linked (5 Mrad) cemented cup in which wear and stability is yet to be determined.

Methods

A total of, 70 hips were included in this case series on the cemented Marathon® cup. Mean age of the patients was 78 years (SD 15). We measured wear and migration by radiostereometry at 3, 12 and 24 months.

Results

The proximal wear rate estimate between 3 to 24 months was 0.036 mm/year, and a total proximal wear estimate at 2 years of 0.11 mm (95% CI 0.09-0.14). Translations and rotations along the 3 cardinal axes were all at or below the precision limit, and less than what is believed to be predictive of later loosening, namely 0.2-1 mm for proximal migration. The cups remained stable after the initial “bedding in” that occurred during the first 3 months.

Conclusions

Our results indicate that moderate cross-linking (5Mrad) yields low wear and high stability in this specific acetabular cup, comparable to other cups with higher cross-linking.
Survival, Clinical and Radiological Outcome of the Zweymüller SL/Bicon-Plus Total Hip Arthroplasty: A 15-Year Follow-up Study
Authors: Ottink Karsten , Barnaart Lex , Westerbeek Robin , van Kampen Karin , Bulstra Sjoerd , van Jonbergen Hans-Peter
Published: May 2015

Aim

The primary aim of this study is to analyse the long-term results of the third generation of the “Zweymüller” total hip arthroplasty (THA) comprising the SL-Plus Stem and the Bicon-Plus cup.

Methods

We evaluated 208 patients with a SL/Bicon-Plus primary THA (218 hips). Survival analysis was performed with a follow-up of 13 to 15 years. Complementary clinical and radiological analysis was performed using the “Hip Injury and Osteoarthritis Outcome Score” (HOOS) and x-rays of the hips.

Results

The probability of survival of the stem and cup with revision for any reason was respectively 0.96/0.97 at 10 years and 0.92/0.94 at 15 years. The probability of survival of the stem and cup with revision for aseptic loosening was respectively 0.99/0.97 at 10 years and 0.95/0.94 at 15 years. Clinical assessment of the patients, reported by the HOOS, were scored with a median for the subdivisions: symptoms 90%, pain 93%, function in daily activity 87%, function in leisure or sport 75%, and quality of life with 75%. Periprosthetic radiolucent lines were observed in half of all hips in Gruen zones 1 and 7. Mean linear wear of the polyethylene was 1.8 mm which corresponds to 0.12 mm/year. 2/3 of the hips show heterotopic ossifications, mostly Brooker type 1 and 2.

Conclusions

The “third generation” Zweymüller total hip arthroplasty consisting of the SL stem and the Bicon cup has good long term results in terms of survival, clinical and radiological outcome.
Epidermolysis Bullosa Acquisita of MRSA Skin Carrier: A Case of Successful Total Hip Arthroplasty
Authors: Homma Yasuhiro , Baba Tomonori , Goto Kenji , Maruyama Yuichiro , Kaneko Kazuo
Published: May 2015

Purpose

Epidermolysis bullosa acquisita (EBA) is a very rare disease of a chronic autoimmune subepidermal blistering, usually manifesting as skin fragility, blisters and erosions. In this article, we report a successful THA in a patient with osteonecrosis of the femoral head with EBA and methicillin-resistant staphylococcus aureus (MRSA) skin carriage.

Methods

A 59-year-old woman had severe and debilitating left hip pain due to osteonecrosis of the femoral head. She had suffered from EBA for the past 7 years. She had received several courses of intravenous steroid pulse therapy in the past, and taking 6 mg of prednisone and 100 mg of minocycline per day for infected skin blisters. Severe blisters and scars covered her body, especially at the prone area. A bacteriological examination taken using a cotton-swab returned MRSA at the nasal cavity and anterolateral part of the proximal femur.

Results

We employed an antibiotic prophylactic protocol used for one-stage revision for infected hip prosthesis. Primary THA was performed using the anterior approach with antibiotic-loaded cement, and the skin was fully covered with a soft and conformable foam dressing.1-year post-op, there are no signs of infection. The Harris Hip Score improved from 37 pre-op to 93.4 at 1 year post-op.

Conclusions

Although care must be taken by medical professionals to avoid the prescription of unnecessary antibiotics, when used appropriately, there appears to be substantial benefits to be gained in the field of joint replacement for patients who are at high risk of infection.
Treatment of Massive Acetabular Bone Loss and Pelvic Discontinuity with a Custom Triflange Component and Ilio-Sacral Fixation Based on Preoperative CT Templating. A Report of 2 Cases
Authors: Hogan Craig , Ries Michael
Published: May 2015

Revision rates for total hip arthroplasty are increasing and pelvic discontinuity is estimated to be present in 1% to 5% (Berry). Discontinuity is defined as a separation of the cephalad portion of the pelvis from the caudad portion (AAOS Type IV defects). This results from bone loss secondary to osteolysis, infection, fracture, or mechanical loosening. The goals of revision surgery in this setting are to obtain secure fixation of the acetabular component with or without union of the discontinuity. Many methods exist for treating this problem. Results with allograft and cage fixation have generally been poor (Berry, Hansen). More favourable outcomes have been reported using either a cup cage technique or custom triflange (Gross, Christie). The custom Triflange component is designed based on preoperative imaging with CT scan to manufacture a custom titanium implant to address the patient's specific bone loss pattern and obtain secure fixation in the ilium, pubis, and ischium. However, we have encountered cases of acetabular discontinuity with massive pelvic bone loss in which bone stock in the ilium was insufficient to provide support for proximal fixation of a conventional custom triflange component.

Currently in the trauma patient population posterior pelvic ring disruptions are being treated with ilio-sacral screw fixation. The sacrum provides a source of secure bony fixation for these injuries.

We report on 2 patients with pelvic discontinuity and massive bone loss using a technique to obtain proximal fixation of a custom triflange component into the sacrum.
Identifying novel biomarkers of gastric cancer through integration analysis of single nucleotide polymorphisms and gene expression profile
Authors: Wang Tao , Xu Yan , Hou Peng
Published: May 2015

Purpose

Single nucleotide polymorphisms (SNPs) are an important cause of functional variation in proteins leading to tumorigenesis. We aimed to identify candidate biomarkers with polymorphisms in gastric cancer (GC).

Methods

The SNP microarray profile GSE29996 including 50 GC samples and 50 normal controls, and gene expression data GSE56807 consisting of 5 GC samples and 5 controls were downloaded from the Gene Expression Omnibus database. After preprocessing of raw data, GC-associated SNPs were identified using the Cochran-Armitage trend test, and differentially expressed genes (DEGs) were screened out using the limma package in R. Significant DEGs with risk associated SNP loci were screened using the Fisher combination test. Gene ontology function and pathway enrichment analyses were performed for DEGs with risk associated SNP loci by GenCLip online tool. Transcriptional regulatory analysis was also conducted for transcription factor and target DEGs.

Results

A total of 79 DEGs with risk associated SNP loci were identified from GC samples compared with normal controls. These DEGs were mainly enriched in anatomical structure development, including embryo development. Additionally, DEGs were significantly involved in the NO1 pathway, including actin, alpha 1, skeletal muscle (ACTA1). In the regulatory network, transcription factor forkhead box L1 (FOXL1) regulated 26 DEGs with risk associated SNP loci, including Iroquois homeobox 1 (IRX1) rs11134044, sex determining region Y (SRY)-box1 (SOX1) rs9549447 and msh homeobox 1 (MSX1) rs41451149.

Conclusions

IRX1, SOX1 and MSX1 with risk associated SNP loci may serve as candidate biomarkers for diagnosis and prognosis of GC.
Early Access Ligation Resolves Presumed Ischaemic Monomelic Neuropathy in a Patient with Recurrence of Central Venous Occlusion
Authors: Coscione Alberto I.L. , Gale-Grant Oliver , Maytham Gary D.
Published: May 2015

Purpose

Ischaemic monomelic neuropathy (IMN) is a rare but serious complication of haemodialysis access procedures, with a highly variable clinical presentation. We present a case of presumed IMN managed with ligation of the prosthetic brachial-axillary access, leading to recovery of neurological function.

Methods

A 75-year-old male who underwent placement of a left prosthetic brachial-axillary access developed a swollen left upper limb following surgery and underwent interventional management for central venous occlusion.

Results

Eleven weeks following placement of the access, he presented with gross swelling and loss of function in the left arm. Ultrasonography excluded nerve compression. The brachial-axillary access was urgently ligated, leading to recovery of function in the arm. Electromyography (EMG) studies confirmed an ischaemic cause.

Conclusions

The pathophysiology of IMN is poorly understood. This case is atypical in that the patient suffered from central venous stenosis prior to the development of IMN. This raises the possibility that the gross swelling secondary to recurrent central venous occlusion may have led to an ischaemic neuropathy by altering nerve perfusion. Early management led to a functional recovery of the affected limb, suggesting that an urgent approach in patients with suspected IMN might be associated with the best outcomes.
Three-Dimensional Ultrasound-Based Target Volume Delineation and Consequent Dose Calculation in Prostate Cancer Patients with Bilateral Hip Replacement: A Report of 4 Cases
Authors: Arcadipane Francesca , Fiandra Christian , Franco Pierfrancesco , Munoz Fernando , Lrgolini Paolo , Trino Elisabetta , Levis Mario , Guarneri Alessia , Ricardi Umberto
Published: May 2015

Aim

To investigate the role of 3D ultrasound (3D-US) in target volume delineation in prostate cancer radiotherapy.

Methods

Four patients with intermediate risk prostate cancer and metal artifacts on planning computed tomography (CT) due to previous bilateral hip replacement underwent 3D-US with the Clarity platform (Clarity System, Elekta, Stockholm, Sweden) to allow for image-guided procedures. Ultrasound and CT images were coregistered to allow for better delineation of the prostate gland and organs at risk (OAR). Electron density override (EDO) and standard electron density (EDS) methods were compared for appropriate dose calculation.

Results

3D-US and planning CT minimized image artifacts, providing better evidence of patient anatomy, particularly regarding soft tissue visualization. Prostate gland and seminal vesicles were better delineated, particularly in the posterior aspect. Anterior rectal wall and bladder neck were more visible. No difference was found in terms of average planning target volume dose, D15%, or D25% for rectum or D15%, D25%, or D35% of bladder between EDO and EDS.

Conclusions

3D-US proved to be a viable tool for target volume and OAR visualization in patients with prostate cancer with hip prostheses.
Concurrent versus Sequential Chemoradiotherapy for Esophageal Cancer among Chinese Population: A Meta-Analysis
Authors: Li Fang , Li Tao , Liu Li , Lv Jiahua , Song Yanqiong , Li Churong , Diao Peng
Published: May 2015

Aims and background

Esophageal cancer can cause substantial mortality and there is controversy about the effectiveness of concurrent and sequential chemoradiotherapy (CRT) for this disease.

Methods and Study Design

Based on established criteria, we searched electronic databases including PubMed, Excerpta Medica Database (Embase), China National Knowledge Infrastruction (CNKI), Wanfang, and Weipu databases up to March 2014 to collect eligible studies. Relative risks (RRs) and their 95% confidence intervals (CIs) were calculated. Q and I2 test were applied to test statistical heterogeneities among studies. Publication bias of total effective rate was evaluated through a funnel plot and sensitive analysis was conducted.

Results

We identified 10 Chinese studies including 1024 esophageal cancer patients. The RRs of total effective rate and 1-, 2-, and 3-year survival rate for concurrent versus sequential CRT were 1.15 (95% CI 1.07 to 1.24), 1.15 (95% CI 1.05 to 1.26), 1.44 (95% CI 1.21 to 1.73), and 1.66 (95% CI 1.37 to 2.01), respectively, all with statistically significant differences (p<0.05). With regards to incidence of leukocytopenia, the RR for concurrent versus sequential CRT was 1.14 (95% CI 1.03 to 1.26) with significant difference (p<0.05). However, the RR of incidence of radiation esophagitis was 1.09 (95% CI 0.96 to 1.22) for concurrent versus sequential CRT without significant differences (p = 0.17).

Conclusions

Concurrent CRT was superior to sequential CRT for esophageal cancer management among Chinese people. Though higher toxic effects were revealed in concurrent CRT, it was tolerable. Therefore, concurrent CRT could be applied into esophageal cancer treatments for Chinese patients.
Supraclavicular and Infraclavicular Lymph Node Delineation in Breast Cancer Patients: A Proposal Deriving from a Comparative Study
Authors: Cucciarelli Francesca , Kirova Youlia M. , Palumbo Isabella , Aristei Cynthia
Published: May 2015

Aims and background

Current advances in radiotherapy for breast cancer require knowledge of the anatomy of irradiated areas to minimize geographic miss and spare organs at risk. This study aimed at defining a contouring approach for supraclavicular (SC) and infraclavicular (IC) nodes after mastectomy or conservative surgery in patients with breast cancer.

Methods and Study Design

In 15 patients, SC and IC nodes were contoured on computed tomography slices according to Madu et al and Dijkema et al. After analyzing relapse sites, as reported by Reed et al, our approach was defined. The 3 methods were compared in all patients, quantifying differences in contours by percentage overlap (PO).

Results

In our approach, SC node delineation is similar to Madu et al in the ventral and medial landmarks, but includes the lateral SC nodes described by Dijkema et al. The lateral landmarks are the scalenus anterior and medius muscle lateral border and the clavicle. Dorsal boundaries are the scalenus anterior and medius muscle ventral and lateral surfaces and the subclavian artery ventral border. In IC node delineation, major differences emerged in cranial and dorsal limits which, in our approach, are the pectoralis minor muscle upper edge and the subclavian axillary artery ventral side. Our mean and median volumes and POs were between the other 2 methods.

Conclusions

This study contributes to standardizing draining node contouring, so as to reduce variability and minimize geographic miss.
Bladder Cancer Diagnosis: The Role of CT Urography
Authors: Capalbo Emanuela , Kluzer Anna , Peli Michela , Cosentino Maria , Berti Elisabetta , Cariati Maurizio
Published: May 2015

Aims and Background

To evaluate the diagnostic performance of computed tomography urography (CTU), we first compared it with cystoscopy and subsequently analyzed which CTU phase of acquisition has the highest diagnostic accuracy in identifying bladder cancer.

Methods

In 2013, 177 patients underwent both cystoscopy and CTU. For all acquisition phases, we calculated sensitivity, specificity, diagnostic accuracy, and positive and negative predictive value (PPV and NPV, respectively). We also evaluated the Cohen K coefficient.

Results

Computed tomography urography sensitivity, specificity, diagnostic accuracy, PPV, and NPV were as follows: 96.3%, 86.4%, 92.8%, 92.9%, and 92.7%; concordance calculated with Cohen K was good: 0.8413. The arterial acquisition phase showed the highest diagnostic accuracy, identifying 93.4% of all lesions.

Conclusions

Computed tomography urography is an accurate examination for the diagnosis of bladder cancer, and the arterial acquisition phase provides the best diagnostic information.
Efficacy of Capecitabine Monotherapy as the First-line Treatment of Metastatic HER2-negative Breast Cancer
Authors: Babacan Taner , Efe Orhan , Hasirci Ahmet S. , Demirci Fatih , Buyukhatipoglu Hakan , Balakan Ozan , Sarici Furkan , Kertmen Neyran , Esin Ece , Akin Serkan , Ates Ozturk , Aksoy Sercan , Sever Ali R. , Altundag Kadri
Published: May 2015

Aims and Background

Capecitabine is a potent and safe agent that can be used after anthracycline and taxane treatment in patients with metastatic breast cancer (MBC). The purpose of this study was to investigate the efficacy and safety of capecitabine monotherapy as a first-line treatment in human epidermal receptor 2 (HER2)-negative patients with MBC.

Methods and Study design

In this single-center trial, a total of 109 HER2-negative patients with MBC who received capecitabine monotherapy as first-line treatment between 2003 and 2014 were retrospectively analyzed. Kaplan-Meier survival analysis was carried out for progression-free survival (PFS) and for overall survival (OS). Two-sided p values of <0.05 were considered statistically significant.

Results

Median PFS was 7.0 ± 0.67 (confidence interval (CI) 5.6-8.3) months and median OS was 30 ± 4.1 (CI 21.8-38.1) months. First-line capecitabine treatment for HER2-negative MBC was more effective in the estrogen receptor (ER)-positive patient population compared to the ER-negative group (median PFS 9 vs 4 months (p = 0.002), median OS 33 vs 21 months (p = 0.01)). Indeed, the overall response rate in the ER-negative group was 16%, while this was calculated as 38% for ER-positive cases. While most of our patient population was treated with a higher dose (1250 mg/m2), the observed grade 3-4 toxicities were lower compared to some previously reported phase II and phase III capecitabine studies.

Conclusions

Capecitabine monotherapy is an effective and safe regimen for ER-positive, HER2-negative patients with MBC. Its low toxicity profile compared to other intravenous cytotoxic agents and the ease of its oral administration make this agent a preferable option for both physicians and patients.
Application of the Holmium Laser Lithotripsy for Bladder Stones under Local Anaesthesia: A Prospective Analysis
Authors: Garg Manish , Kumar Manoj , Goel Apul , Sankhwar Satya Narayan
Published: May 2015

Purpose

The purpose of this study is to determine the feasibility and the results of intracorporal holmium laser (HL) lithotripsy in patients with bladder calculus under local anaesthesia.

Materials and methods

From January 2009 to August 2012, 46 patients underwent HL lithotripsy for bladder calculus under local anaesthesia. Twelve patients who had associated medical comorbidity also underwent the procedure. The pain was evaluated with 10-point visual analogue scale during and 1 h after completion of the procedure. Foley catheter was inserted at the end of procedure in all the patients.

Results

In the present study, the mean stone size was 2.1 cm (1.1–4.2 cm) and the mean operative time was 43 min (range 23–57 min). All patients were rendered stone-free in a single sitting except one patient. The mean pain score intraoperatively and in the postoperative period was 3.84 and 1.47, respectively. There was no major complication during surgery. The procedure was well tolerated and most of the patients were discharged on the same day. After the follow-up period of 3 months, all patients were asymptomatic except one patient who developed a soft stricture in the bulbar urethra and was managed by internal urethrotomy.

Conclusions

Bladder stones can be safely managed by HL lithotripsy under local anaesthesia with a high success rate and minimal morbidity. The procedure is even feasible in high-risk patients with medical comorbidities without extra risk.
Understanding value-based healthcare – an interview study with project team members at a Swedish university hospital
Authors: Erichsen Andersson Annette , Bååthe Fredrik , Wikström Ewa , Nilsson Kerstin
Published: May 2015

The purpose of this study is to explore how representatives from four project teams understand the concept of value-based healthcare (VBHC), since each representative is responsible for one of the pilot projects implementing VBHC at a university hospital in Sweden. A qualitative design was used to gain understanding of VBHC. Open-ended interviews were used as the data-collection method and content analysis of the transcribed interviews was carried out. Participants’ understanding of VBHC focused on how value was created for the patient and on measuring medical outcomes and costs, although costs were to some extent put aside. To measure value for the patients, it was the health professionals’ perspective about what patient should value that dominated the understanding of the concept VBHC. VBHC was understood as a strategy to strengthen value innovations and to loosen the grip of economic control. Benchmarking was seen as a future possibility to develop value innovations. Changes in organizational culture were understood by participants as a need to change healthcare from being professional-centred to patient-centred. The way the concept was understood omits parts of the original concept. This has implications for whether or not the concept as it is described by the participants should be understood as VBHC according to the intentions of the strategy described. The development of outcome measures was predominantly based on the health professionals’ experiences, which is why the patients’ perspective needs to be strengthened. Further studies of the process of implementing VBHC are needed.
Associação entre deficiência de vitamina D, adiposidade e exposição solar em participantes do sistema de hipertensão arterial e diabetes melito
Authors: Ruiz Fabiana Silva , Oliveira Ana Flávia , Simão Andréa Name Colado , Lozovoy Marcell Alysson Batisti , Alfieri Daniela Frizon , Sandrini Fabiano , Dichi Isaias , Dichi Jane Bandeira
Published: May 2015

Atualmente, diversos estudos demonstram uma relação entre deficiência de vitamina D e diabetes melito tipo 2, obesidade e hipertensão arterial. A principal causa de deficiência de vitamina D é a falta de exposição solar adequada. O objetivo deste estudo foi avaliar os níveis séricos de vitamina D e sua associação com ingestão de vitamina D, composição corporal e exposição solar em pacientes participantes do Sistema de Hipertensão e Diabetes da cidade de Cascavel, PR. Participaram 304 adultos e idosos, de ambos os sexos, e foram avaliados os dados demográficos e antropométricos, hábitos de vida, presença de doenças prévias, dietética e a dosagem de vitamina D sérica. Utilizou-se do teste qui quadrado para verificação de associação e aderência e o teste de Kruskal-Wallis para comparação de medianas entre as variáveis estudadas. Verificou-se deficiência sérica de 25-hidroxivitamina D [25(OH)D] (<20ng/mL) em 52,6%, excesso de peso em 73,4%, aumento na circunferência abdominal em 77,6% e na percentagem de gordura corporal em 95,6% dos pacientes. Não houve associação entre a ingestão e os níveis séricos de vitamina D. Houve associação significativa entre circunferência abdominal (p0,001) e exposição solar inadequada (p
Qualidade microbiológica da água do Lago Igapó de Londrina - PR e caracterização genotípica de fatores de virulência associados a Escherichia coli enteropatogênica (EPEC) e E. coli produtora de toxina Shiga (STEC)
Authors: Schuroff Paulo Alfonso , Lima Nicole Ribeiro de , Burgos Tatiane das Neves , Lopes Angélica Marim , Pelayo Jacinta Sanchez
Published: May 2015

Esse trabalho teve como objetivo a detecção e quantificação de Coliformes Totais e Escherichia coli, no Lago Igapó, com a finalidade de avaliar a qualidade destas águas como próprias ou impróprias para recreação, além da caracterização genotípica de fatores de virulência associados a EPEC e STEC pela técnica da PCR. A área de estudo foi o Lago Igapó I, II, III e IV. As coletas foram realizadas mensalmente entre março de 2011 a fevereiro de 2012. A técnica utilizada para detecção e quantificação de Coliformes Totais e E. coli foi a do substrato cromogênico Colilert. Na PCR os genes eae e bfp foram pesquisados para caracterizar o patotipo de EPEC típica; stx1, stx2, eae e hlyA o de STEC e as que apresentaram somente o gene eae foram caracterizadas como EPEC atípica. De acordo com a Resolução CONAMA 357/2005, foi observado que para a recreação de contato primário, apenas o Lago Igapó III foi classificado impróprio, já para recreação de contato secundário, todos os lagos apresentaram-se próprios. Além disso, pode ser observada uma forte relação entre o índice pluviométrico e os índices de E. coli no Lago Igapó, na qual em meses mais secos a sua quantidade decresce drasticamente, enquanto que em meses chuvosos se observava uma relação contrária. Das 97 cepas de E. coli isoladas, duas apresentaram o gene eae (EPEC atípica). Nenhum isolado apresentou os genes stx1, stx2, bfp e hlyA. Desse modo, esperamos conscientizar a população e os órgãos públicos da importância do monitoramento microbiológico das águas recreacionais para prevenção de surtos de infecções de veiculação hídrica.
Cultivo não-fotoautotrófico de microalgas: uma visão geral
Authors: Angelo Elisangela Andrade , Andrade Diva Souza , Colozzi Filho Arnaldo
Published: May 2015

As microalgas são um grupo heterogêneo de microrganismos, dos quais podem ser extraídos diversos produtos tais como: proteínas, carboidratos, pigmentos e óleos com perfil contendo ácidos graxos saturados, poli-insaturados e mono-insaturados. Esses microrganismos apresentam diferentes formas de metabolismo energético, destacando-se o fotoautotrófico, heterotrófico, mixotrófico e fotoheterotrófico. A compreensão destas formas de metabolismo permite aplicar às microalgas estratégias de cultivos visando o aumento da produção de biomassa algal, e seus coprodutos em grandes escalas. Tradicionalmente, o cultivo de microalgas explora seu metabolismo fotoautotrófico. No entanto, estudos têm apontado vantagens da produção de biomassa destes microrganismos por outras vias metabólicas. Desta maneira, essa revisão tem por objetivo apresentar uma visão geral das formas de metabolismo não-fotoautotrófico das microalgas e considerações sobre a produção de biomassa desses microrganismos nesses diferentes sistemas de cultivo. No metabolismo heterotrófico, as fontes de carbono que mais têm se destacado para as microalgas são: glicose, glicerol e ácido acético. Além disso, diversos estudos apresentam fontes alternativas de meio de cultivo, como os resíduos agroindustriais e sanitários. O metabolismo mixotrófico pode ser definido como aquele em que ocorre simultaneamente a fotossíntese e a oxidação de compostos orgânicos externos. No metabolismo fotoheterotrófico, a luz é a fonte de energia e o composto orgânico é a fonte de carbono. Os sistemas de cultivo não-fotoautotróficos de microalgas são de alto potencial, principalmente devido ao aumento de escala e produtividade. No entanto, deve-se ressaltar que informações sobre esses sistemas de cultivo de microalgas em grande escala para uma produção competitiva ainda são escassas.
Análise da atuação das enfermeiras em um modelo de unidades gerenciais
Authors: Segui Maria Luiza Hexsel , Peres Aida Maris , Bernardino Elizabeth
Published: May 2015

Objetivo: identificar os espaços de atuação das enfermeiras após a implantação do modelo de Unidades Gerenciais em uma instituição hospitalar de ensino de grande porte e alta complexidade, da região sul do Brasil. Método: estudo exploratório descritivo de abordagem qualitativa, na modalidade de estudo de caso. Os dados foram coletados por entrevista semi-estruturada com 15 enfermeiras representantes dos cargos ocupados pela categoria na instituição.Resultados: as participantes são do sexo feminino, de 25 a 59 anos, com tempo de atuação no hospital entre 05 e 30 anos, a maioria pós-graduada. As atividades dividem-se em: assessoria em comissões ou comitês, vigilância em saúde, atividades de gerenciamento, assistência de enfermagem, educação em serviço, orientação em saúde, pesquisa e atividades administrativas institucionais. Conclusões: as enfermeiras que trabalham com assessoria sustentam a operacionalização de algumas políticas públicas de saúde; nos cargos da estrutura do Serviço de Enfermagem, atividades estão relacionadas ao gerenciamento do cuidado e da unidade; e nos cargos administrativos externos, visam às demandas institucionais gerais.
A Shifted Power Method for Homogenous Polynomial Optimization over Unit Spheres
Authors: Wang Shuquan
Published: May 2015

In this paper, we propose a shifted power method for a type of polynomial optimization problem over unit spheres. The global convergence of the proposed method is established and an easily implemented scope of the shifted parameter is provided.
How to Regulate Cooperatives in the EU?
Authors: van der Sangen Ger J.H.
Published: May 2015

How to Regulate Cooperatives in the EU? A Theory of Path Dependency

In this article, the phenomenon of path dependency has been addressed in view of the harmonization of cooperative law in the EU. The question is raised whether and how the legislative harmonization has an impact on co-operators in their efforts of setting up and maintaining efficient cooperative organizations and whether in this respect the Statute for the European Cooperative Society (hereinafter: SCE) is a helpful tool to facilitate the enhancement of national statutes on cooperatives as well as to provide the legal infrastructure to facilitate cross-border cooperation amongst and reorganizations of cooperatives in the EU.

The case for the cooperative as a viable business form gained momentum in the EU policy debate with the development of the SCE Statute in 2003, the outbreak of the financial and economic crisis in 2008 and with the endorsement of the cooperative business concept by the United Nations and the International Labour Organization in 2012. If the sound development of cooperatives as an alternative legal business form vis-à-vis investor-owned firms is considered a policy instrument to enhance societal business activities – notably in the field of agriculture and social economy – it raises the question how cooperatives should be regulated to fulfil their function in this respect.

The key argument presented in this article is that due to strong tendencies of path dependency a top-down approach of EU law-making was and is not a feasible option. The cooperative as a multifaceted institution requires a multifaceted approach taking into account the historical legislative developments of distinctive jurisdictions as well as the historical economic development of cooperative organizations in their specific jurisdiction. However, the existence of path dependency and the lack of regulatory arbitrage as well as regulatory competition prevent the market from generating efficient model statutes for cooperatives taking into account the specific needs of cooperatives and their co-operators.
Transnationalization of Agricultural Cooperatives in Europe
Authors: Bijman Jos , Pyykkönen Perttu , Ollila Petri
Published: May 2015

Transnationalization of Agricultural Cooperatives in Europe

Agricultural cooperatives in Europe are increasingly expanding beyond their home countries. A number of these cooperatives have become transnational cooperatives, which means that they have members in more than one country. Examples can be found particularly in the dairy and fruit and vegetables industry. This article presents an overview of the recent internationalization and transnationalization processes among agricultural cooperatives in Europe and is the first academic publication that provides empirical data on cross-border membership. The article discusses the pros and cons of having members in several countries, as well as the different trajectories along which cooperatives may become transnational. Transnationalization entails substantial challenges for the member-cooperative relationship due to differences in culture, language, legislation and business practices. The professional management usually prefers an internationalization strategy above a transnationalization strategy. While further internationalization of agricultural cooperatives is expected, foreign membership will continue to be a major challenge for boards of directors.
To Recognize or Not to Recognize? That Is the Question!
Authors: Sucker Stefanie
Published: May 2015

To Recognize or Not to Recognize? That Is the Question! Motherhood in Cross-Border Surrogacy Cases

This article describes the status quo in cross-border surrogacy cases, more specifically how national courts deal with the recognition of parenthood validly established abroad. As the recognition of motherhood is deemed to violate the national ordre public, the solutions so far, i.e. recognition of fatherhood and adoption, will be examined. Moreover, the arguments for an alleged ordre public-violation concerning motherhood will be presented. Finally, the question whether the European Human Right Convention has an impact on the interpretation of the best interest of the child will be answered.
Motieven voor decentralisatie
Authors: Raijmakers L.
Published: May 2015

Reasons for decentralization in the Netherlands. In between normativity and pragmatics

This article focuses on the administrative relation between the levels of authority in the Netherlands while paying special attention to the distribution of administrative tasks and legislative power between government tiers. How has this process developed since the constitutional reform in 1848? Which motives have underpinned the fluctuating ways in which responsibilities and powers were divided? The constitutional reform of 1848 laid the foundation for the current administrative structure. A three-tier system forms the basis of its organization: national government, regional government (provinces) and local governments (municipalities). This article shows that in the Netherlands the leitmotiv for decentralization is to improve the governmental performance; efficiency, standardization and simplification are recurring objectives. Decentralization is also often used as an instrument to resolve specific policy issues. The article describes a discrepancy between the motives for decentralization, which can be explained by the differences between fundamental legislation involving the administrative structure on the one hand and legislation aimed at policy-making on the other hand.
Niemand slaapt bij ons op straat?
Authors: Staring R.
Published: May 2015

With us nobody sleeps on the streets? On the refugee shelters for illegal aliens and the jousting between central and local government in the Netherlands

Dutch policies concerning the illegal stay of aliens are characterized by regular tensions between central and local governments. This article describes various concrete (proposals for) policy changes in the last twenty years and examines the reasons for these tensions while using the distinction between policy strategies based on denial versus strategies based on adaptation (Garland). When it comes to refugee policies, the central government works in the denial mode while local governments adapt and try to find solutions in order to bring problems under control. This attitude can be explained by the local governments’ duty to provide for in the case of humanitarian emergency situations.
Het Wetsvoorstel vereenvoudiging en digitalisering procesrecht: kanttekeningen vanuit de procespraktijk
Authors: Teuben K. , Jansen K.J.O.
Published: May 2015

Het Wetsvoorstel vereenvoudiging en digitalisering procesrecht: kanttekeningen vanuit de procespraktijk

Deze bijdrage behelst een – deels kritische – analyse van het Wetsvoorstel vereenvoudiging en digitalisering procesrecht, vanuit het perspectief van de procespraktijk. Centraal staan de procedurele wijzigingen die het wetsvoorstel (naast digitalisering) teweegbrengt. De auteurs concluderen dat het wetsvoorstel enkele belangrijke praktijkvragen onbeantwoord laat en op verschillende punten niet leidt tot een vereenvoudiging, maar eerder tot (onnodige) complicatie van het civiele proces. Zij doen enkele suggesties ter verduidelijking en verbetering van het voorstel.
Perchlorate in US Drinking Water: Is a Federal Regulation Needed to Protect Public Health?
Authors: Cotruvo Joseph A.
Published: May 2015

A US regulation for perchlorate in drinking water is in the works, but research as well as cost‐benefit analyses suggest that replacing the current health advisory likely would not provide significant measurable benefits.
Climate Change Adaptation Planning for Small Water Systems
Authors: Maier Michael E. , Carpenter Adam T.
Published: May 2015

Small systems and utilities with limited resources can use this stepwise guide to identify, analyze, and rank system‐specific options for adapting to climate change.
Aging, inflammation and depressive behavior: a review
Authors: Uzoni Adriana , Ovidiu Ciobanu , Sandu Elena Raluca , Buga Ana Maria , Popa-Wagner Aurel
Published: May 2015

One of the most common co-morbidities of cerebrovascular disorders is neuroinflammation, a hallmark and decisive contributor to many central nervous system (CNS) diseases. Although neuropathological conditions differ in etiology and in the way in which the inflammatory response is mounted, cellular and molecular mechanisms of neuroinflammation are probably similar in aging, hypertension, depression and cognitive impairment or after cerebral insult such as stroke. Moreover, a number of highly prevalent risk factors such as hypertension, diabetes and atherosclerosis are increasingly understood to act as “silent contributors” to neuroinflammation – not only establishing the condition as a central pathophysiological mechanism, but also constantly fuelling it. Mild, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease (cSVD) and subsequent dementia. Acute neuroinflammation, often in the context of traumatic or ischemic CNS lesions, aggravates the acute damage and can lead to depression, post-stroke dementia and neurodegeneration. All of these sequelae impair recovery and provide the ground for further cerebrovascular events.
Friendship and Cancer
Authors: Evans Rebecca , Mallet Pascal , Bazillier Cécile , Amiel Phillipe
Published: May 2015

Friendships are a powerful healing force for physical and mental illness. The study of the role of friendship for cancer patients has been relatively neglected and academic evidence-based studies are lacking. A literature review of research was performed linking cancer with friendships and social support (other than that provided by family members or members of medical staff). Some studies report the importance of friendships formed amongst young children and often in a school context; fewer studies have focused on friendships amongst adults with cancer. Direct links between friendships formed and/or maintained amongst cancer patients and their precise effects on an individual’s battle with cancer have yet to be explored.
A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking
Authors: Pohlmann Thomas , Baumann Sebastian , Haag Carl , Albrecht Mario , Feldbrügge Michael
Published: May 2015

An emerging theme in cellular logistics is the close connection between mRNA and membrane trafficking. A prominent example is the microtubule-dependent transport of mRNAs and associated ribosomes on endosomes. This coordinated process is crucial for correct septin filamentation and efficient growth of polarised cells, such as fungal hyphae. Despite detailed knowledge on the key RNA-binding protein and the molecular motors involved, it is unclear how mRNAs are connected to membranes during transport. Here, we identify a novel factor containing a FYVE zinc finger domain for interaction with endosomal lipids and a new PAM2-like domain required for interaction with the MLLE domain of the key RNA-binding protein. Consistently, loss of this FYVE domain protein leads to specific defects in mRNA, ribosome, and septin transport without affecting general functions of endosomes or their movement. Hence, this is the first endosomal component specific for mRNP trafficking uncovering a new mechanism to couple mRNPs to endosomes.