bluuebunny/crossref_metadata_2025 huggingface dataset:
Engagement with community liver disease management across the UK: a cross-sectional survey
Authors: Jarvis Helen , Worsfold Jonathan , Hebditch Vanessa , Ryder Stephen
Published: July 2021

Background

Liver disease is an increasing cause of premature mortality in the UK. Its management in primary care is not well understood. It is unclear what role commissioning bodies are playing in liver disease in the UK.

Aim

To assess the level of engagement with community chronic liver disease management among clinical commissioning groups (CCGs) and health authorities across the UK.

Design & setting

A cross-sectional survey to all UK CCGs and health authorities.

Method

Survey questions were developed by the British Liver Trust, in collaboration with topic experts, and evaluated structures in place relating to liver disease management at commissioning and health board level.

Results

There were 159 responses representing 99% UK coverage of CCGs and health boards. Twenty per cent reported an individual responsible for liver disease within their organisation, with 40% and 29% reporting having pathways in place to respond to abnormal liver blood tests and liver disease more generally, respectively. All those reporting use of pathways reported using national guidelines to guide content. Twenty-five per cent made use of transient elastography (FibroScan) and 16% of direct serum fibrosis markers (for example, enhanced liver fibrosis [ELF] score), which are both part of current National Institute for Health and Care Excellence (NICE) guidelines. There was marked regional variation in all areas of engagement surveyed, with Wales having exceptionally high levels of engagement in all areas in contrast to the other nations.

Conclusion

The results of this survey should be used as a catalyst to highlight necessary regional improvements to the primary care management of chronic liver disease across the UK.
Strategies supporting sustainable prescribing safety improvement interventions in English primary care: a qualitative study
Authors: Shamsuddin Azwa , Jeffries Mark , Sheikh Aziz , Laing Libby , Salema Nde-Eshimuni , Avery Anthony J , Chuter Antony , Waring Justin , Keers Richard N
Published: July 2021

Background

While the use of prescribing safety indicators (PSI) can reduce potentially hazardous prescribing, there is a need to identify actionable strategies for the successful implementation and sustainable delivery of PSI-based interventions in general practice.

Aim

To identify strategies for the successful implementation and sustainable use of PSI-based interventions in routine primary care.

Design & setting

Qualitative study in primary care settings across England.

Method

Anchoring on a complex pharmacist-led IT-based intervention (PINCER) and clinical decision support (CDS) for prescribing and medicines management, a qualitative study was conducted using sequential, multiple methods. The methods comprised documentary analysis, semi-structured interviews, and online workshops to identify challenges and possible solutions to the longer-term sustainability of PINCER and CDS. Thematic analysis was used for the documentary analysis and stakeholder workshops, while template analysis was used for the semi-structured interviews. Findings across the three methods were synthesised using the RE-AIM (reach, efficacy, adoption, implementation, and maintenance) framework.

Results

Forty-eight documents were analysed, and 27 interviews and two workshops involving 20 participants were undertaken. Five main issues were identified, which aligned with the adoption and maintenance dimensions of RE-AIM: fitting into current context (adoption); engaging hearts and minds (maintenance); building resilience (maintenance); achieving engagement with secondary care (maintenance); and emphasising complementarity (maintenance).

Conclusion

Extending ownership of prescribing safety beyond primary care-based pharmacists, and achieving greater alignment between general practice and hospital prescribing safety initiatives, is fundamental to achieve sustained impact of PSI-based interventions in primary care.
PEMANFAATAN TEKNOLOGI VOICE OVER INTERNET PROTOCOL (VoIP) DALAM ONLINE MOBILE GAMES
Authors: Hanindar Muthia , Irwansyah Irwansyah
Published: July 2021

Kemajuan teknologi memungkinkan adanya kemajuan dalam industri video games. Kemunculan perangkat seluler dengan fitur yang semakin canggih memungkinkan khalayak dapat bermain games dimana saja dan kapan saja. Ada waktu luang yang perlu diisi menjadi salah satu alasan utama khalayak dalam bermain game pada ponsel pintar mereka. Kualitas ponsel pintar yang semakin ditingkatkan membuat dunia industri games semakin berkembang dengan adanya fitur-fitur baru dalam game salah satunya fitur komunikasi. Komunikasi sangat diperlukan utamanya dalam permainan yang membutuhkan kerjasama tim. Teknologi Voice over Internet Protocol (VoIP) memungkinkan komunikasi ini terjadi. Dengan menggunakan metode kualitatif, penelitian ini bertujuan untuk melihat kebutuhan khalayak yang dapat dipuaskan melalui media yang dikonsumsi. Melalui teori uses and gratifications 2.0 ditemukan bahwa kebutuhan seseorang dalam bermain game bisa muncul sebelum mengkonsumsi game tersebut ataupun muncul setelah menjelajahi pemakaian media tersebut.

 

Kata kunci: games, ponsel pintar, komunikasi, VoIP, uses and gratifications 2.0
Flirting and Friendship at the Periphery of Hook-up App Research
Authors: Byron Paul , Møller Kristian
Published: July 2021

The everyday intimacies of friendship and flirting are not typically exploredin hook-up app research, nor is there much reflection on the intimacies of researching these media. This paper considers flirting and friendship as practices and methods that broaden the scope of current hook-up app research. We ask what these intimacies can produce to expand research approaches (and thus knowledge) of hook-up apps. As users and researchers of these apps, we consider negotiations of flirting and friendship between researchers and research partici- pants by exploring what it means to research with intimacy. Attention is given to the connections, conversations, and intimate encounters within hook-up research that are mostly absent from existing presentations of research findings. We sug- gest that greater attention to peripheral and intimate communication between researchers and participants can offer valuable methods for queering otherwise stabilised ways of knowing, using, and researching these platforms. Adding to the queer ethnographic tradition, we demonstrate how a processual and affective approach to hook-up app use encourages researchers to make visible our connec- tions to the media we research, and how these connections relate to the intima- cies that hook-up apps foster.
"Fandom's Pornographic Subset"
Authors: Kukka Silja
Published: July 2021

This article draws on content analysis method research (n = 78) that looks at a specific subset of fan fiction: anonymous kink meme communities where mostly women request and write erotic or pornographic fan texts. Reporting on an online survey, this article discusses what kind of role kink meme communities play in the lives of the respondents, how kink meme stories are situated in the larger framework of pornography, and how the respondents view the stories that incorporate unsettling or taboo subjects, such as sexual abuse of children, rape, or incest. This article views kink meme communities as a special subset of fan fic- tion, and in the article kink meme writing is compared to other forms of female- centric erotica or pornography. The article outlines how kink meme communities, like many other female-centric online communities, can function as places where women and gender minorities can write erotic material that better resonates

with them and discuss and explore their sexualities and sexual preferences. Kink meme communities are also shown to utilise queer female writing practices in how they discuss and broaden the cultural view on female sexuality and women’s enjoyment of pornographic material. In addition to this, kink memes are also shown to function as literary communities where some fans can practise their writing.
Por uma ciência da imprevisão
Authors: Esteves Diego Winck , Adó Máximo Daniel Lamela
Published: July 2021

Texto enviado para a seção "Ensaios", a qual não necessita resumo, segundo as normas editoriais que afirmam: "Com exceção do material enviado para seções texto literário, entrevista, ensaio, resenha e imagens, cada texto deve trazer um resumo indicativo e informativo, em português, com o limite máximo de 150 palavras, acompanhado de sua respectiva tradução para língua estrangeira".
O tempo, as palavras e as águas: experiências de leitura em tempos de distanciamento
Authors: Costa Alan Victor Pimenta de Almeida Pales , Romaguera Alda Regina Tognini
Published: July 2021

O tempo, as palavras e as águas: experiências de leitura em tempos de distanciamento
Clinical Pharmacology Aspects in Patients Treated with TNF Inhibitors During SARS-Cov-2 Pandemic
Authors: Ferrara Francesco , Santilli Priscilla , D'Aiuto Vilma , Vitiello Antonio
Published: July 2021

In this period of global pandemic caused by SARS-Cov-2, it is of paramount importance to recognize all risk factors that may increase the likelihood of infection. In addition to the risk factors known as pre-existing diseases and old age, risk factors could be drug treatments for chronic diseases, such as immunomodulating drugs that can alter immune defences and response to infectious agents. Antibodies that inhibit tumor necrosis factor (TNF) such as adalimumab infliximab etanercept and golimumab have been used for over 20 years in severe cases of autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease or ankylosing spondylitis. Due to their mechanism of action they reduce inflammation and can stop the progression of the disease by inhibiting a key factor of inflammation such as Tumor Necrosis Factor (TNF). In this article we want to examine the possible correlation between therapy with TNF inhibitors and the increased risk of SARS-CoV-2 infection, and the possible paradoxical therapeutic efficacy in patients with ongoing infection, especially in phase two and three. We express our opinion on this very complex and sensitive topic which is the subject of discussion among physicians and experts, based on current knowledge of the literature.
A Review on Newer Ocular Drug Delivery Systems with an Emphasis on Glaucoma
Authors: Peter Maneesha , Panonnummal Rajitha
Published: July 2021

Glaucoma is an irreversible condition resulting from the increase in intraocular pressure (IOP); which leads to permanent loss of vision with the destruction of retinal ganglion cells (RGCs). The IOP elevations are controlled in normal by the physiological flow of aqueous humour. A population with age above 40 is more susceptible to glaucoma. Other factors like gender, genetics, race etc. plays major roles in the development of the disease. Current treatment methods available for the disease includes drugs come under the classes of beta receptor blockers, carbonic anhydrase inhibitors, cholinergic agonists, prostaglandins etc. N-methyl-D-aspartate (NMDA) antagonists, inducible nitric oxide synthase (iNOS) inhibition, cytoskeletal agents, Rho-kinase inhibitors etc are few novel targets sites which are in research focus for the treatment of the disease. Developments in nanomedicine are also being evaluated for their potential in treating the growing glaucomatous population. Nanosystems are suggested to avoid the difficulties in tackling the various ocular barriers to a limit, help to decrease the instillation frequency of topical medication and can provide drug delivery in a sustained or controlled manner. This review focuses on the current and emerging treatment methods for glaucoma along with some of the nanoformulations for ocular drug delivery.
The Beginning of a New Era: Artificial Intelligence in Healthcare
Authors: Kumar Akshara , Gadag Shivaprasad , Nayak Usha Yogendra
Published: July 2021

The healthcare sector is considered to be one of the largest and fast-growing industries in the world. Innovations and novel approaches have always remained the prime aims in order to bring massive development. Before the emergence of technology, all the sectors, including the healthcare sector was dependant dependent on man power, which was time-consuming, and less accurate with lack of efficiency. With the recent advancements in machine learning, the condition is has been steadily revolutionizing. in the practice of the health care industry. Artificial Intelligence intelligence (AI) lies in the computer science department, which stresses on the intelligent machines’ creation, that work and react just like human beings. In simple words, AI is the capability of a computer program to think and learn, almost satisfying natural intelligence. It is the ability of a system to interpret the external data correctly, learn from it and finally use those learnings to execute some particular goals and tasks through adaptation. It utilizes multiple technologies to comprehend, act and understand from past experiences. Involving AI is not a science fiction that was once a very long time ago. It AI being an emerging technology has been adopted in various facets of healthcare ranging from drug discovery to patient monitoring. rapidly penetrated its wings developed itself into almost all the industries. Irrespective of the person’s background, whether he/she is a student, industry worker, an entrepreneur, or a scientist, having basic knowledge about the importance and applications of AI would be impactful. Currently, the applications of AI has have been expanding into those fields, which was once thought to be the only domain of human expertise such as health care sector. In this review article, we have shedthrown light on the present usage of AI in the healthcare sector, such as its working, and the way this system is being implemented in different domains, such as drug discovery, diagnosis of diseases, clinical trials, remote patient monitoring, and nanotechnology. We have also slightlybriefly touched upon its applications in touching other sectors as well. The public opinions have also been analyszed and discussed along with the future prospects.The main goals have been briefed. prospects. We have discussed the Along with the merits, we have also discussed about and the other side of AI, i.e. the disadvantages of this as wellin the last part of the manuscript.
Colon Targeted Protein Nanoparticles Loaded Suppositories : Effective against Intestinal Parasites
Authors: Chauhan Swati , Jain Neha , Sharma Shilani , Mehra Shagun , Nagaich Upendra
Published: July 2021

Purpose: The aim of the present investigation was to formulate protein nanoparticles loaded suppositories for colon targeting of metronidazole (MZ), to achieve sustain release effect. Methods: Protein nanoparticles were formulated via desolvation technique by utilizing 2 3 factorial design which results into eight formulations. The synthesized protein nanoparticles were characterized for different physicochemical and in vitro parameters viz. particle size, surface morphology, entrapment efficiency and zeta potential, drug- excipients compatibility studies. Results: The formulated protein nanoparticles were found to be spherical in shape and have an average size in the range of 300.7 nm to 504.8 nm. Based on the results obtained, F7 was found to be the optimized formulation that was loaded into the suppository base. Furthermore, suppositories were also characterized for several parameters like content uniformity, weight variation and liquefaction time. Conclusion: Resultant, suppositories were free from pits, fissures and cracks. The in-vitro release data of metronidazole protein nanoparticles (MZ-PNPs) loaded suppositories were compared with the suppositories loaded with active ingredient only i.e. metronidazole. Screening against Pheretima posthuma was also conducted. The results of in vitro drug release testing proved that protein nanoparticle loaded suppositories is a better approach, compared to pure metronidazole loaded suppositories. Release kinetic study concluded that the formulation follows higuchi’s equation i.e. having a biphasic release pattern. The efficiency of the formulated dosage form was evaluated using Indian earthworms, Pheretima posthuma (P. posthuma).
Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol
Authors: Sheikholeslami Behjat , Tootoonchi Zahra , Lavasani Hoda , Ardakani Yalda Hosseinzadeh , Rouini Mohammadreza
Published: July 2021

Purpose: MDMA (methylenedioxymethamphetamine) is a synthetic compound, which is a structurally derivative of amphetamine. Also, it acts like an amphetamine, structurally, and functionally. MDMA uses mechanism-based inhibition, to inhibit isoenzyme CYP2D6. It can also inhibit other isoenzymes contributing to its metabolism, including CYP3A4 which is the most important member of the cytochrome P450 superfamily. Since more than 50% of drugs are metabolized by CYP3A4, its inhibition may cause harmful and even lethal drug interactions. Tramadol, as an opioid-like analgesic, is mainly metabolized into O-desmethyl tramadol (M1), by CYP2D6 and undergoes N-demethylation to M2, by CYP2B6 and CYP3A4. Due to the significant potential of abusing tramadol, either alone or in combination with MDMA, the rate of its toxicity and side effects may increase following possible MDMA relevant enzyme inhibition. Methods: Different doses of MDMA (1-10 mg/Kg) were intraperitoneally administered to Wistar male rats of both control and treatment groups. Then, after one hour, their isolated livers were perfused by perfusion buffer containing tramadol (1 µg/mL). Afterward, perfusate samples were collected. They were analyzed by HPLC to determine the concentrations of tramadol and its metabolites. Results: MDMA administration in treatment groups reduced M1 production. On the other hand, by following the treatment with different MDMA doses, the M2 metabolic ratio increased by 46 to 101%. Conclusion: it seems that the regular doses of MDMA cannot inhibit the CYP3A4 activity.
Poetics of the epitaph “On the Death of Alexander Druzhinin, January 19, 1864ˮ by Afanasy Fet: genre attributes
Authors: Zhilyakov Sergey V.
Published: July 2021

The article examines the poetics of an epitaph “On the Death...ˮ on the example of the work of the same name proposed for analysis by the poem “On the Death of Alexander Druzhinin, January 19, 1864ˮ by Afanasy Fet. The purpose of the analysis is to determine the genre of the poem, which still remains unclear. The novelty of the author's approach is due to the fact that the discovery through analysis of such genre-forming attributes as genesis dating back to the epicedium (a kind of mourning elegy), genre “concept of personality”, burial portrait, the characteristic principle of figurative visualisation, dating of writing, that allows us to reveal the independent genre status of the poem. It is the genetic heredity of the epicidium, around which other considered genre attributes are concentrated, that helps to define the poem “On the Death...ˮ as a special genre form associated with mortal and memorial genres – the epitaph and the poem “In Memoriam...ˮ. Since the set of genre attributes, the composition of which may vary depending on the object of research, is ideally modelling in nature, the method of its application can be used in the future when studying both the genre poem “In Memoriam...ˮ and other lyric genres.
Grapes in European and Russian Language of Flowers (the 18th –19th centuries)
Authors: Nenarokova Maria R.
Published: July 2021

The article focuses on grapes as an element of the language of flowers, the 18th–19th century cultural phenomenon. Grapes belong to the ancient “core” of the language of flowers. It is considered a polysemantic word or a short sentence. Its use is typical for all European languages of flowers, including Russian. Grapes are often found in fiction. The epithet influences the contextual meaning of grapes. The most common colours are red and yellow, while green is much less used. Red colour enhances the meanings “fun”, “feast”, “carnal pleasures”. Yellow is associated with parental happiness, homeland, friendship, immaculate youth. Green appears in the contexts “trying to hide frustration”, “lack of skill”. The first group of meanings includes “feast”, “joy”, “pleasure”, “carnal love”. The second group of meanings is associated with the field of intellectual activity: “true knowledge”, “narrow-mindedness”. The latter meaning comes from the Russian folklore. Grapes can symbolise poetry and inspiration, and peaceful rural life as well. Since this plant accompanies ancient gods and goddesses, depicted in human form, grapes are used in comparisons that reveal the peculiarities of heroes and heroines' characters.
The image of the “horror” world in the “Fin de siècle” prose (Mikhail Artsybashev, Fyodor Sologub, Leonid Andreyev)
Authors: Khitarova Tatyana Alexandrovna , Khitarova Elena Georgievna
Published: July 2021

The article examines the problem of typological features of the chronotope of the prose of the writers of the “Fin de siècleˮ, who defined the model of the world order in the image of the “horror worldˮ. The goal is analysis of the prose samples of the middle epic of Mikhail Artsybashev, Fyodor Sologub (Teternikov), Leonid Andreyev. Perversion, the corporeality of the depicted reality are the main chronotopic features found in all the literary texts involved for consideration. As we can conclude, the writers of the “Fin de siècleˮ really do make fear and horror a constantly sounding plot-forming motif. However, this constant motif for the literary process of the turn of the century sounds in a unique personal key. The writers offer their own architecture of the image of the “horrorˮ. Thus, the sound of the fear motif is an artistic characteristic of the text, it determines both the dominant of its poetics, and the worldview and attitude of the creator of the text.
Protecting of medical workers from attack: problems of constitutional provision
Authors: Basova Alla V. , Vlasova Marina V. , Barashkov Grigory M.
Published: July 2021

The article is devoted to the study of the problem of ensuring the protection of medical workers from the encroachments of patients and their relatives in the Russian health care system, the study of the level of awareness of physicians about the mechanism for protecting their rights in case of conflict situations when providing medical care to patients. As a result of the conducted research, the authors come to the conclusion that it is necessary to improve the legal literacy of physicians, provide the necessary level of material and technical support for medical workers with modern means of self-defence, and improve the legal regulation of the safety of medical activities. The proposed measures will increase the effectiveness of the implementation of the protection of the rights of medical workers and will become a means of preventing encroachments on them in the health care system. Fostering a respectful attitude of patients to medical professionals, increasing the prestige of the profession in society is an important component of preventing attacks on health workers.
Investigative bodies of Kostroma Region until the creation of the Investigative Committee of the Russian Federation (1944-2007)
Authors: Zaitsev Alexander Vladimirovich
Published: July 2021

The article examines the process of formation of investigative bodies in the territory of modern Kostroma Region, starting from its formation in 1944, and until the creation of a specialised investigative unit in 2007 – the Investigative Department of the Investigative Committee of the Russian Federation in Kostroma Region. The author of the publication, on the basis of the study of archival and other little-known sources, introduces into the scientific circulation new, previously unknown information about the nature and specifics of the activities of the investigative apparatus in the indicated period of time. In the selection of material, preparation and writing of the article, such research methods as comparative analysis, elements of a systemic, biographical, dialectic and historical approaches were used. The main conclusion arising from the published material is the thesis that the establishment of the investigative apparatus in Kostroma Region was quite difficult, due to the lack of qualified personnel and the large volume of investigative and criminalistic activities. However, this process, possessing regional specifics, as a whole took place in accordance with the laws and other regulations in force at that time.
“Even here your uncle has been of use to you!” On the history of creative relationships of Fyodor Dostoevsky and Ivan Goncharov
Authors: Myakinchenko Maria A.
Published: July 2021

The article is devoted to the study of literary and biographical connections between the collision of Ivan Goncharov's first novel “A Common Story” and the conflict between Fyodor Dostoevsky and his guardian Pyotr Karepin. Analysing biographical materials, the author hypothesises that Fyodor Dostoevsky, meeting with Ivan Goncharov, while the latter was working on “A Common Story”, could partly influence the creation of the main collision and central images of the novel. Noting the plot and figurative convergence, the author of the article also shows the ideological difference between Ivan Goncharov and Fyodor Dostoevsky in the presentation of the conflict between uncle and nephew – two different minds, worldviews and representatives of two different generations. The author of the work presents significant and interesting correspondences between the life and creative paths of Ivan Goncharov and Fyodor Dostoevsky, noting the similar literary influences experienced by both writers, and also points to salons and literary circles where they could meet.
STATISTICAL SIMULATION OF FIBRE STRAIGHTENING DYNAMICS IN CARDING ON ROLLER MACHINE
Authors: Sevostyanov Petr A.
Published: July 2021

The article analyses the straightening of fibres in the working areas of roller carding machines. The initial assumptions and parameters are given, which were used to develop a computer model for statistical simulation of the process, taking into account the elastic-viscous properties of fibres and their interaction with neighbouring fibres, based on the methods of statistical dynamics. The dynamics of changes in the straightening of the fibres depending on their initial straightening and the number of passes of the fibres through the working zones are studied. It is established that the partial restoration of the tortuosity of the fibres due to their elasticity does not allow for their complete straightening, regardless of the number of repeated passes of the working areas of the machine.
FACTURE, TEXTURE AND TEHNO-ORNAMENT IN MODERN DESIGN: FUNCTION AND ARTISTIC MEANING
Authors: Beschastnov Nikolay P. , Rybaulina Irina V. , Dergileva Evdokia N.
Published: July 2021

The article is devoted to defining the place and role of textured formations and techno-ornament in modern design, setting out the features of their use and methods of obtaining. The sources of the artistic attitude to the texture and texture of the material in the creation of works of decorative and applied art, interiors are briefly outlined, the importance of increased attention to them in the modern period is revealed. A special role is assigned to techno-ornamentation, which has arisen in high-tech culture and has become an exponent of new rhythmic-plastic images that are in tune with modernity. Images with machine aesthetics with alternating elements that do not have open semantic content. The authors came to the conclusion that in the late 20 th to the early 21 st centuries there was an unprecedented increase in interest in textured and textural ornamental formations. Their images are very vague and associated with an environment largely distanced from humans. Ornament in such an environment is extremely contextual.
SELECTION OAK SEEDLING FOR THE RAPID GROWTH BASED ON MORPHOLOGICAL AND CYTOGENETIC INDICATORS
Authors: Popova Anna , Slavskiy Vasiliy
Published: July 2021

The plantations of the pedunculate oak (Quercus robur L) are the most valuable forestry, ecological, economic and environmental resource. To implement measures for the reproduction of forests, it is necessary to create artificial plantations with planting material with improved hereditary properties. In this regard, the selection of high-quality seeds and fast-growing seedlings of Quercus robur is an extremely topical issue. For the study, we selected objects of oak forests, which have a different degree of recreational load, but are located in identical forest conditions. When collecting experimental material and analyzing the data obtained, generally accepted breeding approaches and methods of statistical processing of results were used. The method of selection by phenotype and fixation of a trait in the offspring justifies itself, but requires acceleration and deepening of knowledge in this direction with the use of modern methods of marker selection. In this connection, the purpose of the work on identifying additional selection criteria that allows for the selection assessment of seedlings is relevant. A close correlation has been established between the height of seedlings and the mitotic index; the height of the seedlings and the pathology of mitosis. It is proposed to use the mitotic index without taking into account cells at the stage of prophase and pathology of mitosis as additional criteria for selecting seedlings for growth rate. On the basis of a comprehensive assessment of the above morphological and cytogenetic characteristics, it is recommended to select highly adaptive and fast-growing seedlings to create forest cultures of Quercus robur
GROWTH OF ANNUAL SEEDLINGS OF LARGE-FRUITED APPLE VARIETIES IN THE SUBURBAN AREA OF KRASNOYARSK
Authors: Gerasimova Olga , Moksina Natal'ya , Bratilova Natalia
Published: July 2021

The article presents a study of the growth rates of annual seedlings of large-fruited varieties of domestic apple (Malus domestica Borkh), grown in the conditions of the upper terrace of the Botanical Garden named after M. Kru-tovsky, Krasnoyarsk. The seeds for cultivation were collected from mother trees growing on the lower and upper terrac-es of the garden. The height of the terraces differs by 28 m. It was revealed that the phenological form of apple varie-ties also affects the growth rates of seed progeny. Large size of aboveground part and weight of one leaf is noted in seedlings of winter varieties. The presence of intervarietal variability in indicators of apple seedlings was established. Fast-growing varieties (Anisik ordinary, Antipaskhalnoe, Papirovka, Pepin saffron) and individual half-sibs (Papirovka No. 44, Cinnamon striped No. 30, Grushovka Moskovskaya No. 34, White filling No. 8 and 27, Slavyanka No. 28, Aport Central Russian No. 1, Titovka No. 1, General Orlov No. 43, variety No. 22 No. 29, etc.), characterized by a greater height and diameter of the stem of annual seedlings, for further selection research
Surface Roughness Analysis of Cotton Fabric by Laser Speckle Technique
Authors: T Anupriyanka , G Shanmugavelayutham , R Prakasam , R Balamurugan
Published: July 2021

In the textile industry, disposing the waste products after dyeing causes a major environmental issue. The mordants used leads to adverse effect for the human and other living organisms. Plasma processing is ecofriendly and it does not produce any waste, pollution free on the environment. Therefore, low temperature plasma treatments are set to make a revolution in textile industry. The present work is to modify the surface of cotton fabric by oxygen plasma treatment with operating parameters such as exposure time, discharge potential and base pressure are kept constant as 5 min, 400V and 9 Pascal respectively. The surface roughness of the fabric is analyzed by laser speckle technique for plasma treated and mordanted fabric and then corresponding results were reported. Further, we observed the increase in surface roughness of the fabric after plasma treatment.
UV Treatment on Inactivation of Fungal Contamination of Sri Lankan Black Pepper (Piper nigrum) seed and powder
Authors: W.A.B.S. Weerasinghe , P.N.R.J. Amunugoda
Published: July 2021

A study was carried out to test the efficacy of UV- C treatment to decontaminate fungal species in black pepper. After preliminary tests carried out using a UV-C drum, a canopy type UV-C sterilization unit was designed and fabricated. Black pepper seed and powder samples were given 10, 15, and 20 minutes UV- C treatments. Results showed that UV-C canopy is effective on inactivation of yeast and moulds in black pepper seeds complying the international microbiological standard requirements for spices. Improvement of UV-C Design modification have been carrying out to obtain the potential inactivation level by UV-C light for black pepper powder and improve the inactivation level of bacteria in black pepper seed and powder.
Kurincippattu - Sulaliyal Nokkil
Authors: P Ilango
Published: July 2021

There are also a color to search for science and literature in literature. Segregation of the scientific previews of the Tamil people has been explicitly examined. Ancient texts are being explored in the highly growing ecosystem in science. The land and water will be dependent on each other. The water and waters of water and waters have explained the land resources that have been explained by the people of the people. The people of the day was aware of the waste of marine water and shower. Plants were deducted on the basis of the other quadratic lands, which was not considered a separate land of the "Paalai 'during the commodity period. Crocodile, Idangar and Karam are flagged. The temple is mentioned. The Monoon longifolium Tree, also known as 'Ashoku' during the pocket, is completely different from the Tamil Nadu mountains and the forests from the forests of the "Actual". The Ashoka tree union is mentioned in the trees and especially hints, the Tamil Nadu has been overwhelming 80 inches per year, and the densely developed forces are maintained to be maintained. It is possible to feel the forest lands and water in Tamil Nadu.
Thirukkuralil manitha urimaigal - A Study
Authors: P Vigneshwari
Published: July 2021

Thiruvalluvar is proud to know and clearly express the ability of the guaranteed objects of virtue, meaning, pleasure and home required for human society. It is a great honor for him that Thiruvalluvar became famous for singing the flute during his lifetime. He is credited with compiling a wonderful book, Thirukkural, which summarizes the facts he has seen and experienced in his life. The human rights mentioned in Thirukkural are an example of Thiruvalluvar's vision. Human beings discriminate between the superior and the inferior and deprive the lower castes of their rights. This leads to many tribulations. Such victims come together and claim their rights. Thirukkural, which appeared in a period of ups and downs, condemns such differences and insists that all people are equal by birth. The king says that if the people are enslaved and persecuted, his wealth will be destroyed by the tears of the people. Therefore, it is clear that the king must provide the necessary facilities for the people. Human rights law makes it clear that if a person is charged, he should be considered innocent until proven guilty. Everyone has the right to freedom of opinion and expression. Anyone who asks for something should explore its true meaning without accepting it as it is. The eye is important to every living thing in the world. Likewise, it is important to get an eye-like education. Everyone should get the best rich education that will never be destroyed. Seeing the war for hunger, Valluvar snarls at those who subjected them to cruelty. The literature that arose for human development is Thirukkural. Thirukkural acts as a medicine wherever and however a human being is injured. If the world listens to the human rights voice of Ayyan Valluvar, there will be no war and no conflict on this soil.
Textile wastewater treatment by UV/Fenton-like oxidation process using Fe-Cu doped pumice composite
Authors: Cifci Deniz İzlen , Meriç Pagano Süreyya
Published: July 2021

In this study, Fe-Cu-Pumice (Fe-Cu-P) composite was prepared to attempt it for UV/Fenton-like treatment of biologically treated textile wastewater by means of COD and color removal. SEM-EDX analysis showed that Fe-Cu-P composite contained Fe and Cu at 3.5% of each one. More than 95% color (RES-436, RES-525, RES-620) removal could be achieved using 3 g/L Fe-Cu-P in the Fenton-like process. The removal of COD and absorbances at Abs-254 nm and Abs-280 nm increased up to 5 g/L Fe-Cu-P concentration. In addition, the highest COD, Abs-254 nm and Abs-280 nm removal could be achieved at 250 mg/L H2O2 concentration pH 3. The removals of COD, Abs-254 nm and Abs-280 nm were obtained to be 63.7%, 66.3% and 72.9%, while the removals of RES-436, RES-525 and RES-620 were observed as 92.9%, 96.7% and 98.1%, respectively at optimum doses of catalyst (5 g/L Fe-Cu-P),  oxidant (250 mg/L H2O2) and pH 3 after 3 h oxidation at room temperature.
COMPARATIVE SEMANTICS: AN INTRODUCTION TO CONCEPTUAL BLENDING THEORY
Authors: Abdul Ghani Khairulanwar
Published: July 2021

Conceptual Blending Theory (Fauconnier & Turner, 2002) aims to provide a general cognitive model related to meaning construction. This theory was created based on the fundamental question raised by contemporary linguists about how a new concept is formed based on the human cognition system. According to Fauconnier, the theory encompasses all domains of meaning creation, whether involving language domains (metaphors, advertisements, and satire) or the use of gestures to convey non -linguistic meaning, such as the way people line up to get tickets at the cinema or certain symbolism in communication. If we can see at the current scenario in linguistic research, this theory has attracted wide attention in various fields of research, from the study of discourse analysis by Oakley (2008), the study of Haiku by Hiraga (1999) to the study of ritual by Sweetser (2000). Due to its holistic nature, it is not surprising that this theory has been heavily criticized by some linguists from the structural school (Broccias, 2004; Gibbs, 2000), and not least there are some Vygotsky scholars (scholars that influenced by Vygotsky thought) who doubted the ability of this theory. Therefore, this paper is written to (i) provide an overview of the proposed theory; (ii) display some analysis of non-linguistic domains based on conceptual blending perspective; and lastly (iii) some counter respond to a previous criticism about this theory.
Теорія зменшення спеклів у лазерному проекторі дуже довгим багатомодовим волокном
Authors: Лапчук А. С. , Горбов І. В. , Пригун О. В. , Морозов Є. М. , Клюєва Т. Ю. , Бородін Ю. О.
Published: July 2021

Проаналізовано ефективність зменшення спеклів стаціонарним багатомодовим оптоволокном у лазерному проекторі. Розроблено та розраховано математичну модель для випадку дуже довгого оптоволокна. Комп’ютерне моделювання та аналіз математичної моделі показали, що коефіцієнт зменшення спеклів може з точністю придатною для інженерних розрахунків бути апроксимований як лінійна функція квадратного кореня відношення числової апертури лазерного проектора та ока. Дуже велика числова апертура, яка на кілька сотень перевищує зіницю людського ока, необхідна для зменшення спеклів нижче чутливості людського ока. Це випливає з того факту, що декореляція в методі використовує лише радіальний напрямок для зменшення спеклів. Для підвищення ефективності методу необхідна його модифікація, де буде передбачено використання азимутального напрямку.
SENYAWA FENOLIK DALAM FRAKSI AKTIF KULIT BUAH Eleiodoxa conferta YANG BERPOTENSI ANTIBAKTERI TERHADAP BAKTERI Streptococcus mutans
Authors: Sasmito Selvia Pratiwi Tri , Wulandari Wulandari , Wulansari Endang Dwi
Published: July 2021

ABSTRACTEleiodoxa conferta (Griff.) Buret fruit peel which is a material that is not widely used, hasbeen studied for antibacterial activity against Streptococcus mutans. Extraction was carriedout using solvents with stratified polarity, n-hexane, dichloromethane and methanol. Antibacterialactivity test showed that the methanol extract of Eleiodoxa conferta fruit peel can provideinhibition of bacterial growth greater than n-hexane and dichloromethane extracts.Methanol extract was fractionated using liquid vacuum chromatography (KVC) to obtainedactive fractions containing phenolic compounds. The content of phenolic compounds in theactive fractions of methanolic extract of Eleiodoxa conferta fruit peel produce zone of growthinhibition of Streptococcus mutans bacteria by TLC-contact bioautography test.Keywords: Eleiodoxa conferta, fruit peel, phenolic compounds, antibacterial, StreptococcusmutansABSTRAKKulit buah asam paya (Eleiodoxa conferta (Griff.) Buret.) yang merupakan bahan yang tidakbanyak dimanfaatkan, dilakukan uji aktivitas antibakteri terhadap Streptococcus mutans.Ekstraksi dilakukan dengan menggunakan pelarut dengan polaritas bertingkat yaitu nheksana,diklorometana, dan metanol. Uji aktivitas antibakteri menunjukkan ekstrak metanolkulit buah asam paya dapat memberikan daya hambat pertumbuhan bakteri lebih besar dariekstrak n-heksan dan diklorometana. Ekstrak metanol difraksinasi dengan menggunakankromatografi vakum cair (KVC) untuk mendapatkan fraksi aktif yang mengandung senyawafenolik. Kandungan senyawa fenolik dalam fraksi aktif ekstrak metanol kulit buah asam payamenghasilkan zona hambat pertumbuhan bakteri Streptococcus mutans dengan uji KLTbioautografikontak.Kata kunci : Eleiodoxa conferta, kulit buah asam paya, senyawa fenolik, antibakteri, Streptococcusmutans
TEA BIOACTIVE COMPOUNDS AS INHIBITOR OF MRSA PENICILLIN BINDING PROTEIN 2a (PBP2a): A MOLECULAR DOCKING STUDY
Authors: Kalalo Marko Jeremia , Fatimawali Fatimawali , Kalalo Tekla , Rambi Christani I J
Published: July 2021

ABSTRACT Methicillin-Resistant Staphylococcus aureus (MRSA) is a hypervirulent multidrug- resistant bacteria. It is spreading around the globe and starting to be a global health problem. It causes bacteremia, infective endocarditis, and bloodstream infection. PBP2a is a protein responsible for MRSA’s resistance to antibiotics, especially beta-lactams. Tea contains bioactive compounds such as polyphenols. It is known to have great antibacterial activities. Therefore, this study aims to find potentials antibacterial compounds from tea polyphenols that can inhibit PBP2a in MRSA with better binding energy than the currently available drugs using the molecular docking approach. We found that theaflavin (-9,7 kcal/mol), as one of the tea polyphenols compound, has a better binding energy with ceftaroline (9,5 kcal/mol) therefore predicted to have better antibacterial activity. (−)- Epigallocatechingallate (-9,1 kcal/mol), (−)-epicatechingallate (-8,8 kcal/mol), myricetin (- 8,7 kcal/mol), quercetin (-8,5 kcal/mol), (−)-epicatechin (-8,3 kcal/mol), (−)- epigallocatechin (-8,3 kcal/mol), kaempferol (-8,3 kcal/mol), procyanidin B2 (-8,1), and theflavindigallate (-7,6 kcal/mol) also have the potential to inhibit MRSA due to its low binding energy. Key words : Molecular docking, MRSA, PBP2a, Tea polyphenols.
Apresentação
Authors: Andreis Greice da Silva Lorenzzetti , Padilha Glauciane Klein Burgiert
Published: July 2021

Apresentação da REMAT, v. 7, n. 1, 2021.
Publicação contínua: 01/01/2021 a 30/06/2021.
A contribuição da hermenêutica para o trabalho do médico radiologista diante das transformações oriundas da inovação tecnológica
Authors: Fortes Garcia Thiago , Nogaro Arnaldo
Published: July 2021

Resumo: No cenário contemporâneo as máquinas têm substituído o trabalhador. Tal transformação leva a pensar no trabalho do médico radiologista, que necessita hoje de outras habilidades, formas de relacionamento com pessoas e com o conhecimento, sugerindo que somente o conhecimento técnico-instrumental pode não ser mais suficiente, pois a inteligência artificial (IA) figura como uma possível ameaça a este profissional. Contudo, seria uma máquina capaz de substituir o homem na forma de pensar, nas relações interpessoais e em suas análises contextualizadas? Buscando respostas, realizou-se uma pesquisa de natureza teórica, de enfoque qualitativo, com o objetivo geral de compreender e demonstrar a contribuição da hermenêutica para o trabalho do médico radiologista diante das transformações decorrentes da inovação tecnológica. A mente humana precisa ser reorganizada e conduzida a novas formas de pensar. Aposta-se, então, na hermenêutica, principalmente por meio do diálogo, para empoderar o radiologista e assegurar a importância do ser humano no exercício da sua profissão.
Palavras-chave: Médico radiologista. Inovação tecnológica. Hermenêutica.
Repensando as práticas pedagógicas a partir do letramento visual e da acessibilidade das pessoas com impedimento auditivo
Authors: Mariani Braz Ruth Maria , Medeiros Portella Sandro , Da Silva Goudinho Luciana , Da Silva Pinto Sérgio Crespo Coelho
Published: July 2021

Resumo: As informações chegam maciçamente na sociedade por meio de textos que podem ser falados, escritos, imagéticos e musicais, dentre tantas outras possibilidades. No entanto, preocupa-nos o acesso que os indivíduos com impedimentos auditivos têm às informações em uma sociedade em que a língua majoritária é a língua portuguesa oral e os registros acontecem, prioritariamente, por meio dessa língua oral na modalidade escrita. Refletindo sobre o potencial da escola como ambiente possível de estímulo à aquisição de língua e inserção em práticas sociais, destacamos o letramento visual e o pensamento computacional como importantes ferramentas na escolarização de discentes com impedimento auditivo. Este artigo tem como objetivo considerar o processo de desenvolvimento linguístico e escolar de discentes com impedimentos auditivos, destacando a proposta bilíngue como fator importante desse processo, aliado ao uso de estratégias e materiais didáticos acessíveis. A metodologia utilizada foi a pesquisa exploratória de cunho bibliográfico narrativo, a partir da qual buscamos estudos nas bases científicas e registros acadêmicos sobre o tema. Como resultado, identificamos que as pessoas com impedimento auditivo têm um potencial visual que deve ser estimulado na aprendizagem dos conteúdos. Quanto aos materiais bilíngues para o ensino da pessoa com impedimento auditivo, é imprescindível considerar o uso de imagens em contextos significativos. Por meio desta investigação concluímos que o tempo da imagem é o tempo da palavra, pois exige do professor bilíngue a maneira apropriada de criar diferentes materiais para os discentes, fomentando e apresentando conceitos de maneira que sejam internalizados e externalizados de forma eficaz e com autonomia. 
Palavras-chave: Educação inclusiva. Acessibilidade. Letramento visual.
Nagyszilárdságú acélok elektronsugaras hegesztett kötéseinek fáradásos repedésterjedéssel szembeni ellenállása
Authors: Sisodia Raghawendra , Gáspár Marcell
Published: July 2021

A kutatómunka az S960QL nemesített és az S960M termomechanikusan kezelt nagyszilárdságú szerkezeti acélok elektronsugaras hegesztett kötéseinek fáradásos repedésterjedéssel szembeni ellenállására irányult. A hegesztési kísérletek során 15 mm vastag alapanyagokat alkalmaztunk hozaganyag nélküli (autogén), I-varratos, hegesztett kötések létrehozásához. A repedésterjedési vizsgálatokhoz alkalmazott hárompontos hajlító (TPB) próbatesteket úgy munkáltuk ki, hogy azok a jellemző irányokra merőlegesek, illetve párhuzamosak legyenek, valamint a bemetszések helyzetét a hegesztett kötések jellemző részeinek (varrat, beolvadási vonal, hőhatásövezet) elemzése céljából is változtattuk. Ennek megfelelően a vizsgálataink során terjedő repedések a valós szerkezetekben előforduló, különböző repedés megjelenési helyeknek felelnek meg. A vizsgált S960M acél elektronsugaras hegesztett kötésének fáradásos repedésterjedéssel szembeni ellenállása a vizsgált irányokban szignifikánsan különbözőnek bizonyult, az S960QL acél esetében ilyen különbség nem mutatkozott. A vizsgált S960QL acél elektronsugaras hegesztett kötései, mindkét vizsgált irányban lényegesen érzékenyebbeknek bizonyultak a fáradással terjedő repedések elhelyezkedésére, mint a vizsgált S960M acél kötései.