bluuebunny/crossref_metadata_2025 huggingface dataset:
Распространенность бруксизма в сочетании с парафункциями жевательных мышц у пациентов различных возрастных групп, обращающихся за стоматологической помощью
Authors: Рубникович С.П. , Денисова Ю.Л. , Кузьменко Е.В. , Грищенков А.С. , Пашкевич С.Г.
Published: December 2023

Для эпизодов бруксизма характерны реакции автономной нервной системы, определяемые по развитию тахикардии и росту симпатического тонуса, усилению дыхания и тонуса жевательных мышц, приводящего к разрушению зубов, что обуславливает актуальность разработки комплексного физиологического подхода для выявления особенностей мозга людей с проявлениями бруксизма и иных состояний, связанных с чрезмерной моторной активностью.
Цель исследования. Оценить распространенность бруксизма и парафункций жевательных мышц у пациентов различных возрастных групп, обращающихся за стоматологической помощью.
Объекты и методы исследования. Проведен анализ данных 1 269 амбулаторных карт пациентов ключевых возрастных групп согласно классификации ВОЗ, обратившихся за стоматологической помощью.
Результаты исследования и их обсуждение. Установлено, что у 6-летних детей бруксизм во сне встречается в 15,5 ± 2,14 % случаев, бруксизм во время бодрствования – в 32,7 ± 1,71 % случаев; у детей в возрасте 12 лет бруксизм во сне – в 14,3 ± 4,54 % случаев, бруксизм во время бодрствования – в 27,5 ± 3,22 % случаев (в 14,3 ± 4,54 % случаев и в 27,5 ± 3,22 % случаев соответственно); у 15-летних подростков бруксизм во сне отмечается в 11,7 ± 2,05 % случаев, бруксизм во время бодрствования – в 25,5 ± 1,75 % случаев. У пациентов в возрасте 35-44 лет бруксизм во сне фиксируется в 12,3% ± 2,71 % случаев, бруксизм во время бодрствования – в 26,8 ± 3,28 % случаев. У пациентов ключевой группы в возрасте 65-74 лет бруксизм во сне встречается в 6,4 % ± 1,48 %, бруксизм во время бодрствования – в 15,3 ± 2,05 % случаев.
Заключение. На основании проведенного исследования выявлено, что частота встречаемости бруксизма во сне имеет тенденцию снижаться с возрастом. Полученные данные указывают на преобладание бруксизма во время бодрствования над бруксизмом во сне в два раза. Установлена положительная корреляционная связь между наличием парафункций жевательных мышц, бруксизма, а также зубочелюстных аномалий и деформаций у пациентов всех возрастных групп.
Вакуумная проба Кулаженко на стойкость капилляров десны – архаизм или метод объективизации функционального состояния тканей пародонта* (патофизиологический аспект проблемы)
Authors: Иорданишвили А.К. , Мороз П.В. , Бобынцев И.И.
Published: December 2023

Для исследования тканей пародонта, воспалительные и дистрофические заболевания которых встречаются более чем у 50 % населения Земли, используют реопародонтографию, лазерную допплеровскую флоуметрию, ультразвуковую высокочастотную допплерографию (эхоостеометрию) и другие методы, часто недоступные для учреждений здравоохранения из-за необходимости приобретения дорогостоящей специальной аппаратуры, а также подготовки персонала по функциональной диагностике.
Цель исследования. Провести корреляцию оценки состояния тканей пародонта при хроническом генерализованном пародонтите** (ХГП) с помощью современных методов функциональной диагностики и с использованием пробы, позволяющей определить стойкость капилляров десны.
Объекты и методы исследования. Обследованы 152 пациента в возрасте 45-56 лет, из которых у 36 человек патология в пародонте не диагностирована, 116 имели ХГП различной степени тяжести. Для оценки морфофункционального состояния тканей пародонта у всех пациентов применили капилляроскопию, лазерную допплеровскую флоуметрию, пробу Кулаженко, определили индекс периферического кровообращения в десне Дедовой (ИПКД). С помощью указанных методов у страдающих ХГП состояние пародонта было оценено также спустя месяц после завершения комплексного лечения.
Результаты исследования и их обсуждение. Предложенные в прошлом веке проба Кулаженко и созданная на ее основе методика индексной оценки периферического кровообращения в тканях десны четко и достоверно коррелируют с показателями, полученными с помощью современной техники для изучения гемомикроциркуляции.
Заключение. Эти методы должны сохранить свою актуальность для практической стоматологии, тем более применение пробы Кулаженко оказывает существенное положительное лечебное воздействие на ткани пародонта при наличии воспалительной патологии, а использование ИПКД позволяет объективно оценивать эффективность лечебных и профилактических мероприятий, в том числе при диспансеризации пародонтологических пациентов.
Pengaruh Motivasi, Literasi Keuangan, Dan Demografi Terhadap Perencanaan Keuangan Untuk Mencapai Kebebasan Keuangan
Authors: Raharjo Magda Endrica , Santoso Bambang Hadi , Satrio Budhi
Published: December 2023

Perencanaan keuangan merupakan langkah awal untuk mencapai kebebasan keuangan guna mencakup tujuan keuangan yang perlu dicapai. Skor indeks kesehatan keuangan pada masyarakat Indonesia masih relatif rendah, hanya sebesar 37,72 dari skor maksimal 100, hal ini semakin menegaskan bahwa literasi keuangan sangat penting bagi masyarakat yang ingin mencapai kebebasan keuangan. Tujuan penelitian ini untuk mengetahui pengaruh motivasi, literasi keuangan, dan demografi terhadap perencanaan keuangan keluarga    dan kebebasaan keuangan. Populasi penelitian ini adalah investor PT. XYZ Sekuritas Surabaya. Penentuan sampel menggunakan metode non probability sampling dengan jumlah sampel  sebanyak  180.  Teknik analisis  menggunakan partial least square. Hasil penelitiaan ini memperlihatkan motivasi, literasi keuangan, dan demografi berpengaruh signifikan terhadap perencanaan keuangan dengan p value 0,000. Motivasi,dan literasi keuangan, berpengaruh signifikan terhadap kebebasan keuangan melalui mediasi perencanaan keuangan dengan p value 0,000 dan 0,046. Saran penelitian selanjutnya dapat menambahkan variabel lain yang diduga dapat mengidentifikasi Self Control, serta faktor dari demografi seperti pendapatan dan juga jumlah anggota keluarga.
Sistem Audit Teknologi Informasi Berdasarkan Cobit Untuk Menilai Level Of Maturity Berbasis Web
Authors: Chotijah Umi
Published: December 2023

Teknologi informasi dan komunikasi (TIK), tak dapat dipungkiri, memainkan peran yang penting dalam agenda transformasi tiap perusahaan. Tak terkecuali bagi Semen Indonesia Group (SIG) yang membutuhkan dukungan operasional untuk digitalisasi proses bisnis dan penunjang kegiatan operasional sistem informasi perusahaan. Saat ini, teknologi informasi atau sistem informasi yang ada pada PT. SIG dikelola oleh Department of ICT. Department of ICT atau unit departemen pelayanan ICT, merupakan sebuah departemen perusahaan yang bertanggung jawab dalam mengelola teknologi informasi atau sistem informasi pada PT. SIG, Jika tidak memiliki tingkat penanganan yang tepat, teknologi informasi seperti itu tentu memiliki risiko-risiko yang tidak dapat dihindari, untuk mengatasi hal tersebut  diperlukan tata kelola terhadap penggunaan teknologi informasi atau sistem informasi. Beberapa permasalahan yang ada antara lain adanya kesulitan atau kendala yang dialami oleh auditor dalam melakukan audit teknologi atau sistem informasi pada departemen pelayanan ICT karena masih menggunakan metode konvensional dalam lingkungan pemrosesan data elektronik. Penelitian ini bertujuan merancang dan membangun sistem audit teknologi informasi sesuai dengan standar COBIT 5.1 yang dapat mendukung kerja auditor dalam kegiatan audit teknologi informasi.  Rancang bangun sistem audit teknologi informasi berbasis web menghasilkan suatu aplikasi Audit Teknologi Informasi Berbasis web dimulai dari pembuatan flowchart sistem lalu pembuatan data flow diagram (DFD) dan entity relationship diagram (ERD). Sistem pemilihan yang dibangun melibatkan auditor sebagai entitas luar. Rancang bangun sistem audit teknologi informasi berbasis web menghasilkan suatu aplikasi Audit Teknologi Informasi Berbasis web menggunakan Maturity Level tools yang terdapat dalam Framework COBIT 5.1. Desain aplikasi ini berbentuk Radio Button dengan acuan hasil pemetaan Proses Teknologi Informasi berdasarkan COBIT 5.1. Aplikasi ini Membantu auditor dalam mengevaluasi informasi hasil audit dan membantu auditor dalam melakukan analisis hasil Audit. Metode yang digunakan dalam pengembangan membangun sistem audit teknologi informasi adalah waterfall. Berdasarkan hasil implementasi dan pengujian, sistem audit teknologi informasi telah sesuai dan memenuhi persyaratan fungsional yang telah ditentukan dari proses pengujian.
Penerapan Database Redis Sebagai Optimalisasi Pemrosesan Kueri Data Pengguna Aplikasi SIRESMA Berbasis Laravel
Authors: Nur Ramadhan Ilham , Saraswati Galuh
Published: December 2023

Penelitian ini mengevaluasi penggunaan basis data Redis dalam aplikasi SIRESMA berbasis Laravel untuk mengatasi masalah keterlambatan pemrosesan kueri data. Hasil pengujian menunjukkan bahwa implementasi Redis telah berhasil meningkatkan signifikan kecepatan akses sebagian besar endpoint API, dengan total peningkatan waktu respons sekitar 6,74%. Namun, perlu diperhatikan bahwa ada beberapa endpoint tertentu yang mengalami penurunan performa, yang mengindikasikan bahwa penggunaan Redis harus disesuaikan dengan karakteristik data dan penggunaan aplikasi untuk mendapatkan hasil yang optimal. Sementara itu, penelitian mendatang dapat mempertimbangkan alat diagnosis kueri yang lebih rinci dan alternatif lain untuk meningkatkan performa aplikasi.
Pengoptimalan Performa Database Pada Proses Transformasi Data Pada SQL Server
Authors: Setiya Budi Desi , Syahrial Hadi
Published: December 2023

Database sendiri secara umum adalah kumpulan data yang disimpan secara sistematis di dalam komputer yang dapat diolah atau dimanipulasi menggunakan perangkat lunak (program aplikasi) untuk menghasilkan informasi. Pendefinisian database meliputi spesifikasi berupa tipe data, struktur data dan juga batasan-batasan pada data yang akan disimpan. Salah satu tools yang sering digunakan adalah SQL Server.  Pengolahan data sendiri membutuhkan waktu yang tidak sedikit melalui berbagai tahapan. Saat tahapan proses data ada yang disebut dengan transform data dan transfer data. Yang artinya data dikirim dari proses A ke Proses B dan diubah. Dalam hal ini bukan informasi dari sebuah data, namun yang diubah bukan isi atau nilai yang ada di dalamnya, namun merubah manjadi bentuk informasi yang dapat dengan mudah diterima dan dibaca oleh pembaca informasi. Pada proses transform dan transfer, ada beberapa kendala yang dialami. Yang sering terjadi adalah masalah waktu. Waktu merujuk pada kecepatan sebuah proses data itu sendiri. Karena apabila setiap proses memilik kecepatan yang sangat lamban itu akan memakan banyak waktu, padahal masih banyak proses lain yang harus berjalan. Pada penelitian ini, penggunaan teknik  Indexing, Temporary Table dan gabungan antara keduanya dilakukan. Guna mendapatkan hasil mana yang lebih cepat untuk digunakan. Pada penelitian ini menggunakan metode True Experiment Design dengan rancangan pengukuran berulang. Yang mana pada penelitian ini akan mendapati beberapa perlakuan, dan dilakukan denga lebih dari satu kali percobaan.
Analisis Potensi Ekonomi dan Kelayakan Usaha Budidaya Ikan Mas (Cyprinus carpio) Pada Lahan Bekas Padi Di Patoko Kecamatan Walenrang, Luwu Sulawesi Selatan
Authors: Syamsuri Syamsuri , Alang Hasria
Published: December 2023

The purpose of this study is to analyze the economic potential and feasibility of goldfish farming in Patoko Village, Luwu Regency. The type of research is descriptive, while the variables of this research are the economic potential and the feasibility of goldfish farming on former paddy land. Data collection was carried out by simple random sampling through observation and interviews. The results of the study indicate that the business of cultivating carp in former rice planting fields has economic potential because it is profitable and can finance the operational needs of the business. This cultivation business is also considered feasible to be restarted based on the analysis results of OP, BCR, PP, BEP production and value, as well as the ROI value.
Strategi Pengembangan Usaha Buah Strawberry Beku di Bali Food Industry
Authors: Dwi susanti Ida ayu Made , Kartika Lestari Putu Fajar , Nenggo Ulrikus Rivaldus
Published: December 2023

Strawberry is one of the potential subtropical fruit commodities to be developed. This study aims to identify internal and external factors in developing a frozen strawberry business in the Bali Food Industry and to analyze the strategy for developing a frozen strawberry business in the Bali Food Industry. Data analysis techniques used IFAS, EFAS, I_E Matrix and SWOT Matrix (Strength, Weakness, Opportunity) and Threats). The results of the study show that the internal factors that influence the Frozen Strawberry Development Strategy in the Bali Food Industry consist of strengths and weaknesses. The strength factor has the same value, namely 0.48 (strong), while the weakness factor is the long delivery process and the unfavorable weather factor is still lacking with each value of 0.12 (weak). External factors consist of opportunities and threats. The opportunity factor has the same value in each statement, namely 0.64 (strong) while the threat factor, namely competing companies, increased production costs and increased consumer bargaining position, is still lacking with each value of 0.16 (weak). The strategy for developing frozen strawberries in the Bali Food Industry consists of maintaining quality according to PSAT standards to meet consumer demand, increasing stock of raw materials to increase production capacity, optimizing production to be able to compete with competing companies, optimizing production to be able to compete with competing companies and increasing capital to increase production capacity.
Pengaruh Harga, Produksi dan Kualitas Emping Melinjo Aceh Terhadap Kepuasan Konsumen
Authors: Supristiwendi Supristiwendi , Marlita Yenni , Anzhita Silvia
Published: December 2023

Persaingan bisnis emping melinjo Aceh sangat ketat tingkat lokal maupun regional. Tujuan penelitian adalah untuk menganalisis tingkat kepuasan konsumen  dan pengaruh harga dan kualitas terhadap kepuasan konsumen emping melinjo Aceh. Teknik pengambilan sampel penelitian dilakukan dengan metode “snowball sampling”. Metode analisis data yang digunakan yaitu: analisis kepuasan konsumen menggunakan indeks kepuasan CSI (Costumer Satisfaction Index) dan analisis Structural Equation Modelling (SEM) dengan pendekatan Partial Least Square (PLS). Konsumen merasa sangat puas terhadap atribut rasa dan kualitas emping melinjo Aceh. Indikator harga yaitu; keterjangkauan, kesesuaian, harga bersaing dan manfaat benar-benar mencerminkan atribut harga. Indikator rasa, keawetan, mudah diolah dan tekstur benar-benar mencerminkan atribut kualitas. Indikator terus membeli, terus konsumsi dan rekomendasi benar-benar mencerminkan atribut kepuasan konsumen. Atribut harga tidak berpengaruh terhadap kepuasan konsumen dan atribut kualitas berpengaruh positif dan signifikan terhadap kepuasan konsumen emping melinjo Aceh.
Pengaruh Harga, Jumlah Pengadaan dan Penyaluran Beras Terhadap Stok Beras di Perum Bulog Kantor Wilayah Jambi
Authors: Asmaida Asmaida , Suryadi Suryadi
Published: December 2023

Perum BULOG is one form of SOE whose general business scope is in the field of food logistics, one of the commodities is rice. Rice is an agricultural product which is the basic need of the people of Jambi Province which is the highest source of carbohydrates compared to other types of food. The purpose of the study is to describe the condition of rice stocks in Perum BULOG Jambi Regional Office and the variables that affect these rice stocks in the 2018-2021 time period. The analysis technique used is multiple linear regression analysis. The results showed that the development of rice stocks at Perum BULOG Jambi Regional Office in the 2018-2021 period showed fluctuating data and tended to decrease. Simultaneously, the variables of rice prices at the farmer level, rice prices at the merchant level, the amount of rice procurement from within, the amount of rice procurement from outside (imports), and rice distribution have a significant effect on rice stocks at Perum BULOG Jambi Regional Office in 2018-2021. Partially, rice price variables at the merchant level and rice distribution variables have a significantly negative effect on rice stocks at Perum BULOG Jambi Regional Office in 2018-2021, while rice price variables at the farmer level, rice procurement variables from outside (import), and rice procurement from inside do not have a significant effect on rice stocks at Perum BULOG Jambi Regional Office in 2018-2022.
Strategi Standarisasi dan Sertifikasi Produk Pangan Pada Pasar Rakyat Gianyar
Authors: Dwi Susanti Ida Ayu Made , Pratiwi Luh Putu Kirana , Sukanteri Ni Putu , Budiasa Made
Published: December 2023

The agribusiness system consists of a production subsystem, a processing subsystem (upstream-downstream agro-industry), a marketing subsystem and supporting institutions. The revitalization of each agribusiness subsystem must continue to be improved due to the increasing consumer appetite for the agribusiness system (diversification), especially the subsystem of supporting institutions, namely the people's market. This can also occur due to changes in consumer behavior and perceptions of the people's market. This change is caused by the increasing development of technology and public communication in obtaining information. Especially, regarding the cleanliness and quality of food products. Through Interpretive Structural Modeling (ISM) analysis, a strategy for standardization and certification of food products was obtained at the Gianyar People's Market.
Pelestarian Warisan Kebudayaan Melayu Menyumbang Kepada Penjagaan Agama
Authors: Termizi Adib
Published: December 2023

Penciptaan manusia adalah sebuah penciptaan yang indah bukan dari sudut fizikalnya sahaja tetapi dari perkara luaran yang meliputinya juga. Di antara keindahan tersebut Allah SWT menjadikan manusia terbahagi kepada beberapa bangsa dan dari setiap bangsa terdapat pecahan suku-suku di dalamnya. Bangsa-bangsa manusia ini kemudiannya dilengkapkan dengan adat budaya tersendiri yang menjadi identiti dan membina jati diri mereka. Namun kebanyakan generasi kini berpandangan warisan budaya mereka adalah sebuah kemunduran dan perkara lapuk yang tiada impak yang signifikan dalam kehidupan di zaman moden ini lantas ianya dilupakan. Bertambah menyedihkan apabila budaya warisan bangsa lain lebih diagungkan dan diterima sebagai cara kehidupan berbanding warisan bangsa sendiri. Justeru artikel ini cuba meninjau bagaimana Islam menjaga warisan sesebuah bangsa dan melihatnya berperanan dalam menjaga agama dan nasab. Penulis menggunakan kaedah analisis dokumen dalam penulisan ini bagi melihat pandangan sarjana Islam dalam pelestarian sesebuah budaya dan kepentingannya. Hasil kajian menunjukkan budaya Melayu telah berintegrasi dengan ajaran Islam dan pelestariannya membawa kepada penjagaan agama Islam itu sendiri secara tidak langsung.
Kanun Tanah Wakaf Negara: Adakah Satu Keperluan
Authors: Sulaiman Abdul Aziz , Zainuddin Noor Hidayah
Published: December 2023

Semenanjung Malaysia masih menggunapakai KTN sebagai rujukan dalam pelbagai urusan tanah wakaf. Urusan pendaftaran hak milik tanah wakaf juga menggunakan pakai kaedah seperti ditetapkan dalam seksyen 416C KTN. Namun, seksyen ini hanya menetapkan MAIN sebagai pengelola dan pengurus tanah wakaf dan bukannya sebagai pemilik tanah wakaf. Kesannya, tanah wakaf boleh diambil oleh PBN untuk tujuan pembangunan sedangkan tanah wakaf tidak boleh dijual, dihibahkan atau ditukar hak milik. Disinilah perlunya Kanun Tanah Wakaf Negara diwujudkan bagi rujukan perundangan tanah wakaf.

 Kata kunci: Kanun Tanah Wakaf Negara, undang-undang, tanah, wakaf, hak milik.

 

Peninsular Malaysia still uses Land Code 1965 as a reference in various matters of waqf land. The matter of registration of waqf land title also uses the method as prescribed in section 416C Land Code. However, this section only designates MAIN as the organizer and manager of waqf land and not as a waqf land title. As a result, waqf land can be acquired by PBN for development purposes whereas waqf land cannot be sold, given or converted. This is where the National Waqf Land Code is established for the legal reference of waqf land.

Keywords: National Waqf Land Code, law, land, waqf, title.
Financing The Development of Artificial Intelligence Maid: An Analysis Of Pertinent Fiqhi Issues
Authors: Sitiris Miszairi , Busari Saheed Abdulahi , Md. Sawari Mohd Fuad , Zaim Muntaha Artalim
Published: December 2023

Artificial Intelligence (AI) is the latest machine technology that is replacing the effort of humans and is the fastest-growing sector across the globe. The underlying ethos of AI is to create a secure ecosystem for every human endeavour. Investors are claiming that the invention of an AI assistant such as a robot maid is the future reality. The AI robot is unstoppable and will obstruct how things are done at home. The development of AI and the demand for it indicates a future challenge to domestic activities. Since technology is replacing human efforts, scholars and researchers are concerned about the permissibility of Islamic banks to finance AI projects for the development of robot-maid. A robot maid is likely to exploit gender issues simply because consumers might prefer an AI maid that is male or female. Social violation in the use of AI maid will likely trigger further queries. This study uses the doctrinal approach of the qualitative method to explore Islamic thresholds and analyzes the juristic consideration for financing the development of AI for human development. The study explains the understanding of AI, its contributions to the world economy, and some pertinent issues and challenges. This study found that the growth of AI interventions in homes and care services is a reality, but financing AI maids requires adherence to Islamic requirements, including Shariah compliance and consideration of ethical, economic, security, and social concerns.
Porcine And Bovine-Derived Ingredients: Islamic Rules in Halal Pharmaceutical Products
Authors: Mahamad Maifiah Mohd Hafidz , Wan Ismail Wan Nur Ezzah Syahirah
Published: December 2023

For Muslims, ingesting or utilising any products derived from porcine is forbidden as it is considered unclean. Besides, although bovine is halal to be consumed, this ruling is only applicable if it is slaughtered strictly according to Islamic law (Shari’ah). In view of Islam’s imposing certain restrictions on the consumption of porcine- and bovine-based products, for Muslims who are seeking medication, this could limit their therapeutic options as many pharmaceutical products are sourced from both animals. This will eventually make it difficult for them to get treatment and will endanger their lives. Hence, it is crucial for every Muslim to have knowledge and understanding about the views of Islamic jurists (Fuqaha’) regarding the Islamic rules on pharmaceutical products containing porcine- and bovine-derived ingredients. In this article, a clear narration regarding porcine and bovine-derived pharmaceutical products, accompanied by a review of Islamic rules based on Islamic jurists, is presented.
Death Khairat Fund Principles and Practice In Kota Damansara Mosque According To Hifz Al-Mal
Authors: Shahbuddin Zawin Hannan Sofea , Gunardi Setiyawan , Ab Rahman Azman , Salleh Ahmad Zaki , Syed Omar Syed Mohd Najib , Mohd Noor Khairunneezam
Published: December 2023

The Death Khairat Fund, or the Death Khairat Money Scheme (DKMS), is a pure culture practiced among the Muslim community. Usually, this fund will be managed by the mosque institution to make it easier for the local community to make payments and get direct benefits in the event of death. This fund has become necessary for the average Muslim community in funeral management. This is because the benefit of this fund in providing equipment and assistance for complete funeral management has simplified the process of funeral management that needs to be done by the heirs. However, the study of the explanation of the Death Khairat Fund with any principle of Maqasid Shariah has not yet been studied, especially from the point of view of property protection (hifz mal). Therefore, this preliminary study analyses the relationship between the Death Khairat Fund and Maqasid Shariah. The researcher has succeeded in this study by using a qualitative method consisting of analysis of articles, newspapers, books, and interviews with the management of the Death Khairat Fund in the mosque, which was selected face-to-face has been done. As a result, the study found that the practice of Death Khairat Fund is very much in line with the concept of hifz mal from the point of view of Maqasid Shariah because the use of individual property in this fund can have a significant impact on the good of the people and does not lead to any harm and harm. A further study of the relationship between the Death Khairat Fund and other Maqasid Shariah concepts is necessary to see the extent of the importance and need of this fund from the Islamic perspective.
Ketegasan Rasulullah Berhubung Isu Akidah: Analisis Hadis-Hadis Berkaitan Gereja Dan Salib
Authors: Azmi Ahmad Sanusi , Zaman Rahim Kamarul
Published: December 2023

The organisation of the “Jom Ziarah Gereja” programme under the purview of the Youth and Sports Ministry has spark an intense debate recently. Scholars, muftis, and authoritative parties express their respective views on the issue that are seen to be related to the faith of Muslims. There are among those who take a firm stand, rejecting the clearance that opens the door for Muslims to explore and delve into the activities behind the worship rooms of other religions. While the others restricted with conditional permission, for those who want to enter a church, monastery or any premises that carry out ritual activities for non-Muslims. This paper explores hadiths that are related to the issue of entering a non-Muslim house of worship. The analysis on the sources of related hadith is focusing to matan involving church institutions only, in accordance with the polemics that are floating around in society. The stance and actions of the previous companions, tabi'in and salafussoleh are also included in this study to provide an inclusive and conclusive picture of the issues highlighted. The findings of this study found that the Prophet ﷺ was strict towards elements of other religions that were seen trying to exert influence on Muslims. Even so, conditional consent is given in some situations that are deemed to be essential that require Muslims to enter the church.
Reading the Older People Researches in Architecture through Bibliometric Analysis (1975-2022)
Authors: Midilli Sarı Reyhan , Eyüboğlu Hande
Published: December 2023

The increase in the elderly population all over the world has made it necessary for many disciplines, from health to psychology, from economics to humanities, to conduct field-oriented studies. Architecture is one of the disciplines that play an important role in old age in terms of its relationship with the built environment. This study aims to reveal the intellectual structure, research topics, and trends of scientific studies on elderly users in the discipline of architecture. In this study, in which bibliometric analysis of articles for older adults was made in the Web of Science database between 1975 and 2022, the structure of the field and relations were analyzed by creating science maps through performance analysis and VOSviewer software. In the analyzes made, it has been seen that the number of articles on the elderly has increased in recent years. Although it has a wide distribution in terms of subject variety; housing, aging in place, age-friendly environment, and accessibility are the current topics in the field. This study contributes to the literature by presenting the current course of elderly user-oriented studies in architecture from a bibliographic perspective. On the other hand, it is thought to be a guide for new research by revealing the deficiencies in the field.
Formas peatonales contemporáneas. del plano desplazado al espacio complejo
Authors: León-Vivanco María Fernanda
Published: December 2023

INTRODUCTION: The pedestrian space has evolved along with the needs of the city in which it is implemented, considering the different social, political and cultural phenomena that have influenced urban life. OBJECTIVE: This article develops a classification and characterization of the different forms of the contemporary pedestrian space, in order to infer criteria that allow us to propose a more complex pedestrian structure, the pedestrian network. METHOD: Using a descriptive and qualitative approach, an analysis of various case studies is carried out, to determine common or distinctive characteristics that allow us to understand their structure. RESULTS: The analysis of these cases has allowed to classify them into: multilevel pedestrian spaces –those that have moved the circulation plane to levels other than level 0–, pedestrian areas –that function as autonomous environments for the pedestrian– and pedestrian axes – which are the basic forms of organization of the pedestrian space. These forms contain the fundamental characteristics of the contemporary pedestrian space and the essence of their introduction in the construction of the city. DISCUSSION AND CONCLUSIONS: The evolution of contemporary pedestrian space leads to recognition of the need for a more complex urban structure, extended throughout the urban area, that contemplates and integrates the characteristics of pedestrian spaces: the urban pedestrian network, conceived not in function of isolated elements but of interconnected and continuous elements, which serve the entire city.
Analysis of Hate Speech in Instagram Social Media Celebrity Indonesia Chandrika Sari Jusman
Authors: Merlyn Titahena  , Prihadi
Published: December 2023

The development of information and communication technology today makes it easier for someone to interact with other people. The current interaction process can be done through social media. But what has been found now is that social media is also abused by irresponsible parties by spreading hate speech. This study aims to describe the form and meaning of hate speech against Selebgram Chandrika Sari Jusman on Instagram social media. This research is a descriptive-qualitative research. The data collection method used is the method of observing and noting. The data analysis method in this study refers to the Miles and Huberman model which includes data reduction, data presentation and drawing conclusions. The results of the study showed that there were 25 assertive utterances, 15 directive utterances, 50 expressive utterances, and 10 declarative utterances. The most commonly found utterances are expressive utterances.
PSEUDOMONAS AERUGINOSA MULTIRRESISTENTE EM ISOLADOS DE EFLUENTE HOSPITALAR E DOMÉSTICO NA REDE COLETORA PÚBLICA
Authors: Dallanora Fabio , Dallanora Léa Maria Franceschi , Dallanora Andressa Franceschi , Bohneberger Gabriela , D Agostini Fernanda Maurer , Carvalho Diego , Remor Aline Pertile
Published: December 2023

O gênero Pseudomonas spp é de grande interesse no estudo de multirresistência uma vez que uma espécie, a Pseudomonas aeruginosa, está incluída como Prioridade 1 na relação de agentes patogênicos prioritários da Organização Mundial da Saúde. O presente estudo teve por objeto a detecção da bactéria em rede pública coletora de efluentes em um município do meio oeste de Santa Catarina. Para tal, foram obtidas amostras de efluentes em quatro pontos distintos, incluindo o esgoto oriundo de ambiente hospitalar (P1), doméstico e comercial (P2), ambiente interno à estação de tratamento (P3) e sua consequente liberação ao corpo hídrico ambiental (P4), bem como avaliado o comportamento fenotípico frente à fármacos incluídos em sete diferentes classes pela técnica da difusão radial. Foram isoladas 153 cepas pertencentes ao gênero em estudo dos quais 50 em P1(esgoto hospitalar), 37 em P2 (esgoto público na entrada do reator), 24 em P3 (esgoto público na saída do reator) e 21 em P4 (liberação das águas residuais após tratamento, ao corpo hídrico ambiental). Quando submetidas ao antibiograma, o comportamento frente aos antimicrobianos testados foi distinto entre as cepas, sendo que uma delas, em especial, mostrou resistência frente as seis classes de fármacos testados, ao longo de toda a rede coletora de esgoto. A cepa identificada foi de Pseudomonas aeruginosa e considerada multifármaco-resistente. Em suma, o conjunto dos dados sugerem que os genes de resistência, de acordo com os dados coletados, estão disseminados ao longo de toda a rede, podendo ampliar e/ou contribuir com a resistência bacteriana observada.
AVALIAÇÃO DAS ATIVIDADES ANTIOXIDANTE E LEISHMANICIDA DE ZANTHOXYLUM SYNCARPUM TULL. (RUTACEAE)
Authors: Ferreira Júnior José Milton , De Sousa Silva Antônio Adailson , Tavares Calixto Júnior João , De Vasconcelos Silva Maria Goretti , Maia de Morais Selene
Published: December 2023

O presente estudo traz como objetivo central a avaliação da atividade antioxidante em extratos etanólicos de folhas e galhos de Zanthoxylum syncarpum Tull. (Rutaceae), bem como a avaliação dos efeitos tóxicos desses extratos frente a três espécies do gênero Leishmania. Para tanto, além do extrato etanólico das folhas, obteve-se a fração rica em alcaloides derivada do extrato etanólico dos galhos do Z. syncarpum (EEGZS - FA), cujo composto majoritário, o ácido 4-(N-metilamino) benzoico, foi isolado e identificado por ressonância magnética nuclear (RMN) de 1H e 13C. Como resultado, o extrato etanólico das folhas de Z. syncarpum (EEFZS) apresentou os melhores desempenhos na atividade antioxidante, possivelmente relacionado à presença de compostos polifenólicos. A atividade leishmanicida para o mesmo extrato apresentou CL50 com valores de 14,99 ± 3,35; 13,88 ± 2,62 e 15,25 ± 3,44 µg/mL contra L. infantum chagasi, L. amazonenses e L. brasiliensis respectivamente. Destarte, a partir dos resultados obtidos, conclui-se que extratos de folhas de Z. syncarpum Tull. apresentam-se de forma eficaz como alternativa para o desenvolvimento de novas drogas com efeito leishmanicida.
Pemberdayaan Poklahsar dalam Pengolahan Ikan Bandeng Menjadi Produk Unggulan
Authors: Wulandari Yeni , Muzayanah Fety Nurlia , Azzahra Fatimah
Published: December 2023

Poklahsar Sumber Jaya Ikan merupakan salah satu UMKM perikanan di Desa Muarabaru yang fokus pada pengolahan ikan bandeng. Keterbatasan SDM, kurangnya pengetahuan dan teknologi pemasaran produk menjadi kendala. Hal tersebut dapat dilihat dari aktivitas Poklahsar hanya memproduksi dan memasarkan produk ikan bandeng saat ada pesanan dan belum adanya digital marketing. Kegiatan pengabdian ini bertujuan untuk: 1) Memberdayakan Poklahsar melalui diversifikasi pengolahan produk berupa bandeng untuk meningkatkan pendapatan masyarakat; 2) Meningkatkan keterampilan Poklahsar dalam pengemasan produk yang baik; 3) Meningkatkan keterampilan manajemen usaha dan digital marketing. Metode yang digunakan yaitu sosialisasi manajemen usaha, penguatan Lembaga, digital marketing, pelatihan pengolahan produk, pendampingan dalam pembuatan akun market place dan label produk. Hasil kegiatan menunjukkan keterampilan Poklahsar meningkat dalam manajemen usaha dan digital marketing pengemasan produk yang baik. Hal ini ditunjukan dengan kemampuan mitra dalam pembagian jobdesk yang jelas dengan struktur organisasi yang dibentuk dan perluasan pemasaran melalui market place. Peningkatkan omset 2 kali dari omset sebelumnya adanya penambahan variasi produk olahan sehingga juga meningkatkan pendapatan dan perekonomian desa.
Using ‘pup multipliers’ to estimate demographic parameters of Mediterranean monk seals in the eastern Mediterranean Sea
Authors: Karamanlidis AA
Published: December 2023

A thorough understanding of population demographics is important in planning and evaluating conservation actions. At the same time, it is also essential that conservation management strives to minimize uncertainty in decision making in order to avoid management errors, which in the case of endangered species might affect their persistence. Mediterranean monk seals are endangered and have been notoriously difficult to count, especially in the eastern Mediterranean Sea, where abundance estimates have relied mainly on expert judgement. To address this problem, a new approach to estimating the species’ demographics using ‘pup multipliers’ is introduced. Adopting a conservative and a more optimistic approach and following a review of the available species- and taxa-specific data, the following multipliers were proposed: 2.5-3.5 for estimating the number of mature individuals, and 4.5-6.0 for estimating the total number of individuals. These multipliers were then used to calculate, in a formal way, the population demographics of the Mediterranean monk seal in the eastern Mediterranean Sea and globally. In their current form, the pup multipliers proposed present a number of strengths, but also several caveats, limitations and/or points of concern and should therefore not be considered a panacea in the conservation of the species, but merely the starting point of efforts for further development. These efforts should ultimately aim at developing a population-specific pup multiplier for the Mediterranean monk seal that is based on a common monitoring approach between various countries and includes the collection of newborn pup count data from across the species’ range in the eastern Mediterranean Sea.
Adam of Dryburgh, Soliloquium de instructione animæ
Authors: Damian-Grint Peter
Published: December 2023

Adam of Dryburgh ( d.1212) was one of the greatest theologians of the Premonstratensian Order in the twelfth century. His most popular work was his Soliloquium de instructione anime, a handbook on religious life in the form of a dialogue between Anima, a dissatisfied novice, and a fatherly novice-master Ratio. Lively, realistic and entertaining, their conversation covers all kinds of difficulties a novice might face, from having to keep silence or abstain from meat, to temptations against chastity, the ordeal of being accused of faults against the Rule or having to confess to one’s own abbot, leading Anima through arguments and exhortations to a more profound and supernatural understanding of his vocation. This edition and translation, based on fifteen manuscripts (some not previously known), presents the newly identified earliest redaction of Adam’s text, which contains a significant amount of material missing from later versions. Also included are details of all known manuscripts of the text.
Bilateral abducens nerve palsy from post-spinal-anesthesia-induced bilateral chronic subdural hematoma: case report
Authors: Shiferaw Mestet Yibeltal , T/Mariam Tsegazeab Laeke , Aklilu Abenezer Tirsit , Shumbash Kibruyisfaw Zewudie , Akililu Yemisirach Bizuneh , Worku Bethelhem Yishak , Ayele Mengistu
Published: December 2023

Background

A chronic cranial subdural hematoma arising after post-spinal anesthesia is a rare but serious and life-threatening complication of spinal anesthesia. It usually mimics the typical post-spinal-anesthesia headache or post-dural-puncture headache, potentially masking its detection. Abducens nerve palsy tends to occur in chronic subdural hematoma of post-dural-puncture etiology rather than in cases attributed to other causes of subdural hematoma. Preferential damage to the abducens nerve is frequent and can be attributed to its anatomic course because the abducens nerve runs in the direction of the typical caudad displacement of the brain related to intracranial hypotension.

Observation

Here, we present a report on the clinical presentation, pathogenesis, and management of two cases that developed bilateral abducens nerve palsy following post-spinal anesthesia administered for cesarean sections due to obstetric indications.

Lesson

Post-spinal-anesthesia-induced chronic subdural hematoma, although a rare, life-threatening complication, must be differentiated from post-spinal-anesthesia headache and treated surgically. Cranial nerve palsy (more commonly called abducens nerve palsy) is more common in post-spinal-anesthesia-induced subdural hematoma than subdural hematomas of other etiologies as the cerebrospinal fluid brain cushioning is partly lost. Cranial nerve palsies resolve in most cases if surgery is performed in a timely manner.
Dysregulated coagulation system links to inflammation in diabetic kidney disease
Authors: Xiao Mengyun , Tang Donge , Luan Shaodong , Hu Bo , Gong Wenyu , Pommer Wolfgang , Dai Yong , Yin Lianghong
Published: December 2023

Diabetic kidney disease (DKD) is a significant contributor to end-stage renal disease worldwide. Despite extensive research, the exact mechanisms responsible for its development remain incompletely understood. Notably, patients with diabetes and impaired kidney function exhibit a hypercoagulable state characterized by elevated levels of coagulation molecules in their plasma. Recent studies propose that coagulation molecules such as thrombin, fibrinogen, and platelets are interconnected with the complement system, giving rise to an inflammatory response that potentially accelerates the progression of DKD. Remarkably, investigations have shown that inhibiting the coagulation system may protect the kidneys in various animal models and clinical trials, suggesting that these systems could serve as promising therapeutic targets for DKD. This review aims to shed light on the underlying connections between coagulation and complement systems and their involvement in the advancement of DKD.
Bibliometric analysis of global research trends in adeno-associated virus vector for gene therapy (1991-2022)
Authors: Jiang Fengqi , Zhang Chuanhe , Liu Weina , Liu Fangyuan , Huang Haiyan , Tan Yao , Qin Bo
Published: December 2023

Background

Gene therapy involves introducing and editing foreign genes in the body to treat and prevent genetic diseases. Adeno-associated virus (AAV) vector has become a widely used tool in gene therapy due to its high safety and transfection efficiency.

Methods

This study employs bibliometric analysis to explore the foundation and current state of AAV vector application in gene therapy research. A total of 6,069 publications from 1991 to 2022 were analyzed, retrieved from the Science Citation Index Expanded (SCI-E) within the Web of Science Core Collection (WoSCC) of Clarivate Analytics. Institutions, authors, journals, references, and keywords were analyzed and visualized by using VOSviewer and CiteSpace. The R language and Microsoft Excel 365 were used for statistical analyses.

Results

The global literature on AAV vector and gene therapy exhibited consistent growth, with the United States leading in productivity, contributing 3,868 papers and obtaining the highest H-index. Noteworthy authors like Wilson JM, Samulski RJ, Hauswirth WW, and Mingozzi F were among the top 10 most productive and co-cited authors. The journal “Human Gene Therapy” published the most papers (n = 485) on AAV vector and gene therapy. Current research focuses on “gene editing,” “gene structure,” “CRISPR,” and “AAV gene therapy for specific hereditary diseases.”

Conclusion

The application of AAV vector in gene therapy has shown continuous growth, fostering international cooperation among countries and institutions. The intersection of gene editing, gene structure, CRISPR, and AAV gene therapy for specific hereditary diseases and AAV vector represents a prominent and prioritized focus in contemporary gene therapy research. This study provides valuable insights into the trends and characteristics of AAV gene therapy research, facilitating further advancements in the field.
Optimal postoperative delirium prediction after coronary artery bypass grafting surgery: a prospective cohort study
Authors: Ma Ying , Sui Dongxin , Yang Shaozhong , Yang Xiaomei , Oldam Joseph , Semel Jessica L. , Wang Zhihao , Fang Ningning
Published: December 2023

Background

Postoperative delirium (POD) presents as a serious neuropsychiatric syndrome in patients undergoing off-pump coronary artery bypass grafting (OPCABG) surgery. This is correlated with higher mortality, cognitive decline, and increased costs. The Age-adjusted Charlson Comorbidity Index (ACCI) is recognized as an independent predictor for mortality and survival rate. The purpose of our study is to estimate the predictive value of the ACCI on the POD in patients undergoing OPCABG surgery.

Methods

This prospective cohort study enrolled patients undergoing OPCABG surgery between December 2020 and May 2021 in Qilu Hospital. Patients were divided into the low-ACCI group (score, 0–3) and the high-ACCI group (score ≥4) according to their ACCI scores. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and CAM were used to diagnose POD within 7 days after surgery. The general, laboratory, and clinical data of the patients were recorded and collected. The characteristic ROC curve was applied to further assess the predictive value of the ACCI for POD in patients following OPCABG surgery.

Results

A total of 89 patients were enrolled, including 45 patients in the low-ACCI group and 44 patients in the high-ACCI group. The incidence of POD was higher in the high-ACCI group than in the low-ACCI group (45.5% vs. 15.6%, P = 0.003). Multivariate logistic regression analyses showed that the ACCI (OR, 2.433; 95% CI, 1.468–4.032; P = 0.001) was an independent risk factor for POD. The ACCI accurately predicted POD in patients following OPCABG surgery with an AUC of 0.738, and the Hosmer–Lemeshow goodness of fit test yielded X2 = 5.391 (P = 0.145).

Conclusion

The high-ACCI group showed a high incidence of POD. The ACCI was an independent factor associated with POD in patients following OPCABG surgery. In addition, the ACCI could accurately predict POD in patients following OPCABG surgery.

Clinical Trial Registration

ClinicalTrials.gov, identifier CHiCTR2100052811.
Clinical utilisation of implantable loop recorders in adults with Fabry disease—a multi-centre snapshot study
Authors: Roy Ashwin , Vijapurapu Ravi , Kurdi Hibba , Orsborne Christopher , Woolfson Peter , Kalla Manish , Jovanovic Ana , Miller Christopher A. , Moon James C. , Hughes Derralynn A. , Geberhiwot Tarekegn , Steeds Richard P.
Published: December 2023

Fabry disease (FD) is an X-linked deficiency of alpha-galactosidase-A, leading to lysosomal storage of sphingolipids in multiple organs. Myocardial accumulation contributes to arrhythmia and sudden death, the most common cause of FD mortality. Therefore, there is a need for risk stratification and prediction to target device therapy. Implantable loop recorders (ILRs) allow for continual rhythm monitoring for up to 3 years. Here, we performed a retrospective study to evaluate current ILR utilisation in FD and quantify the burden of arrhythmia that was detected, which resulted in a modification of therapy. This was a snapshot assessment of 915 patients with FD across three specialist centres in England during the period between 1 January 2000 and 1 September 2022. In total, 22 (2.4%) patients underwent clinically indicated ILR implantation. The mean implantation age was 50 years and 13 (59%) patients were female. Following implantation, nine (41%) patients underwent arrhythmia detection, requiring intervention (six on ILR and three post-ILR battery depletion). Three patients experienced sustained atrial high-rate episodes and were started on anticoagulation. Three had non-sustained tachyarrhythmia and were started on beta blockers. Post-ILR battery depletion, one suffered complete heart block and two had sustained ventricular tachycardia, all requiring device therapy. Those with arrhythmia had a shorter PR interval on electrocardiography. This study demonstrates that ILR implantation in FD uncovers a high burden of arrhythmia. ILRs are likely to be underutilised in this pro-arrhythmic cohort, perhaps restricted to those with advanced FD cardiomyopathy. Following battery depletion in three patients as mentioned above, greater vigilance and arrhythmia surveillance are advised for those experiencing major arrhythmic events post-ILR monitoring. Further work is required to establish who would benefit most from implantation.