bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroprotective effects of Tetrapleura tetraptera fruit extract on hippocampal histological features in pentylenetetrazol-induced kindling in Wistar rats
Authors: F. Iniodu Clementina , J. Ekandem Gabriel , B. Ekong Moses
Published: February 2025

Seizures are a hallmark of epilepsy and often lead to cognitive impairment. However, most antiepileptic medications have limited efficacy in this context and are associated with negative consequences with prolonged use. Tetrapleura tetraptera, an antioxidant-rich plant known for its anticonvulsant properties, prompted this study to examine its role in hippocampal protection after pentylenetetrazol (PTZ)-induced kindling. Phytochemical screening and median lethal dose assessments of the T. tetraptera fruit extract (TFE) were conducted. Forty-nine male Wistar rats (150 – 200 g, n=7 per group) were assigned as follows: Control, TFE (500 mg/kg), PTZ alone (40 mg/kg), and PTZ (40 mg/kg) following sodium valproate (200 mg/kg) or TFE at low (250 mg/kg), intermediate (500 mg/kg), and high (1,000 mg/kg) doses over 21 alternate days. PTZ was administered intraperitoneally, while all other treatments were given orally. On day 22, spontaneous alternation behavior (SAB) was assessed, followed by euthanasia and histological analyses. Phytochemical analysis of TFE identified phenols, alkaloids, and flavonoids as key constituents, and its oral median lethal dose was greater than 5,000 mg/kg. Pre-treatment with TFE showed suppressed seizures with quantal protection (p<0.05) compared to the PTZ group. While SAB was not significantly different, hippocampal Nissl expression was mildly affected, and neuron-specific enolase (NSE)-positive cells and glial fibrillary acidic protein (GFAP)-positive cells significantly decreased (p<0.05) compared with the control group. Therefore, oral administration of TFE is safe in Wistar rats with protection against PTZ-induced seizure and mortality. While short-term memory remained unaffected, the hippocampal Nissl substance, NSE, and GFAP were preserved, particularly in the low and intermediate TFE dose groups.
Medicinal plants as more sustainable therapeutic solutions: Artemisia annua and Artemisia afra as case studies
Authors: Weathers Pamela J.
Published: February 2025

Humans have used botanicals as traditional medicines for millennia, yet Western biomedicine has shunned many of these as undefined and often unreliable. While not all botanicals have a strong scientific basis or can be directly used as therapeutics, two, Artemisia annua and Artemisia afra, are quite well-established for their safety and efficacy within ethnopharmacological and scientific literature. A. annua, being better studied, is especially effective against many diseases. It is inexpensive, has consistent phytochemical content within a cultivar grown in its local region, evades the evolution of parasite drug resistance, and can be reliably produced on both large and small scales. Well-defined botanical drugs offer major benefits for more sustainable global health-care. This review highlights these two plant species as examples of how the broader implementation of botanical drugs can decrease costs, promote environmental sustainability, and deliver economic benefits – especially to rural communities – by empowering them to manage their health-care needs more sustainably. Comparisons are made between the agricultural and production costs of an extracted natural product versus Artemisia as a traditional botanical medicine. The review also examines the impact of climate on these two crops and provides a brief comparison of the carbon footprints of traditionally produced botanical drugs versus their commercially produced counterparts. A specific, successful example of sustainable production of A. annua is also described. Overall, there are many well-established reasons to advocate for broader approval of botanical drugs to strengthen global health-care systems.
FXR1 modulates the expression of oncogenes and tumor suppressor genes associated with poor cancer prognosis
Authors: Khan Faiz Ali , Ji Xin-Ying , Ji Shaoping , Dong Jingcheng
Published: February 2025

Post-transcriptional regulation by RNA-binding proteins (RBPs) is critical for mRNA stability, localization, and translation, primarily through interaction with the 3’-untranslated region. Dysregulation of RBPs has been associated with various cancers, with fragile X-related protein 1 (FXR1) emerging as a critical RBP involved in tumorigenesis through its interactions with target mRNAs. Despite its significance, the specific role of FXRI in cancer progression remains underexplored. In this study, we investigated FXR1’s function using SH-SY5Y cells. RNA immunoprecipitation (RNA-IP) assay was employed to isolate RNA complexes associated with FXR1. We generated stable cell lines with either FXR1 overexpression or silencing to assess the impact of FXRI binding to mRNA complexes. Subsequent analyses, including quantitative reverse transcription polymerase chain reaction, correlation analysis, gene expression profiling, and survival analysis, were performed to validate the interactions of FXR1 with target mRNAs. Our RNA-IP analysis identified several mRNAs significantly enriched in FXR1-bound RNA complexes, including SHISAL1, SLC43A3, NBAT1, PDZK1IP1, ACKR3, KCNN3, NECAB2, ANO5, ATOH8, IGFBP7, LEMD1, GPR35, WNT7A, and F2RL3. Notably, we observed changes in the expression levels of these genes following FXR1 overexpression or depletion, indicating FXR1-mediated functional regulation. Co-expression analysis further supported FXR1’s association with these target mRNAs. These findings highlight the significant role of FXR1 in regulating the stability and expression of key mRNAs implicated in malignancies. The dysregulation of FXR1 and its interaction with these target transcripts suggest that FXR1 plays a critical role in tumor biology, potentially offering new avenues for therapeutic interventions. This study provides a deeper understanding of FXR1’s involvement in cancer and underscores the importance of RBPs in the post-transcriptional regulatory landscape of cancer progression.
Recent metaheuristics on control parameter determination
Authors: Olmez Yagmur , Ozmen Koca Gonca , Hakan Akpolat Zuhtu
Published: February 2025

Metaheuristics have been widely used in recent years for tuning control parameters since they have a simple structure, are easy to apply, and provide efficient solutions. In this study, control of a two-wheeled mobile robot using the inverted pendulum principle is proposed. The performances of nine recent metaheuristics (Political Optimizer, Equilibrium Optimizer, Aquila Optimizer, Flow Directional Algorithm, Cheetah Optimizer, Golden Jackal Optimizer, Artificial Rabbit Optimization, Gazelle Optimizer, and Pelican Optimization) have been investigated for the balancing and speed control of a two-wheeled vehicle. In this context, a framework consisting of two cascaded PI controllers is designed to provide balance and speed control of the two-wheeled vehicle. The performances of the recent metaheuristics are also compared with previously introduced effective metaheuristic algorithms for further evaluation. The parameters of the controllers are tuned by using these metaheuristics. In experimental studies, quantitative and qualitative analyses are performed for evaluation of the metaheuristics. The dynamic system properties, convergence curves, computational times, and statistical results are provided to prove optimal control performances. The results show that 11 out of 14 compared algorithms produce similar optimal results in speed and balance control of the two-wheeled vehicle. The rest of them do not provide satisfactory results for the tuning of optimum control parameters of the two-wheeled vehicle.
An in-depth critical analysis of Morgellons: Delusion or disease?
Authors: Haq Bisam-Ul , I. Zaidi Kashaf , Nikookam Yasmin , Irfan Mahnoor , Khan Shehryar
Published: February 2025

Morgellons is a poorly understood entity and is characterized by cutaneous findings such as fibers emerging from the skin, which can cause secondary symptoms such as formication and itching. Morgellons is an understudied area with conflicting results; this imposes challenges to clinicians while navigating consultations and understanding, diagnosing, and treating Morgellons. This literature review summarizes the available data on the etiology, epidemiology, clinical presentation, treatment, and social media influence within Morgellons. Medical Subject Headings terms were used to systematically search PubMed, Medline, and EMBASE, and two independent reviewers screened the selected articles, revealing that Morgellons is poorly understood among the scientific community, with a population prevalence of 3.65/100,000. The etiology of Morgellons is controversial, and opinions among psychiatrists and dermatologists are conflicting. Some studies propose a biological origin linked to Lyme disease, whereas others view Morgellons as a delusional disorder without an underlying pathology. The conflicting views can be attributed to the lack of robust research with no consensus on an established pathophysiology, disease classification, or treatment guidelines. Herein, the majority of literature views Morgellons as a delusional disorder, wherein an underlying pathology triggers the delusional experience. However, further studies are required to accurately classify the disease and direct patients to the right specialists to ensure effective treatment and development of treatment guidelines. Nevertheless, a holistic treatment approach, integrating psychosomatic and dermatological modalities, is lacking.
The importance of clinical and radiological follow-up after conservative treatment of iatrogenic type A aortic dissection: A case report
Authors: Niclauss Lars , Dulguerov Filip , Gunga Ziyad , Nowacka Anna , Kirsch Matthias
Published: February 2025

Background: Iatrogenic type A dissections can be managed conservatively, but clear guidelines for treatment are lacking. Case presentation: This case illustrates a borderline situation that necessitated a change in treatment approach. A patient underwent endo-prosthetic treatment for an aneurysm. During the insertion of a guiding catheter through the axillary artery, the ascending aorta was dissected, with contrast injected into the vascular wall. Due to the mechanism of injury and the absence of an intra-aortic intimal tear (as evidenced by contrast stagnation in the false lumen), conservative management was initially chosen. A follow-up computed tomography (CT) scan showed complete resolution after 1 month. However, 10 days later, the patient was readmitted with acute chest pain, and a new CT scan revealed an acute dissection, with a free-moving intimal flap in the ascending aorta, requiring emergency surgery. Current guidelines recommend surgery for iatrogenic type A dissections that extend or propagate several centimeters into the ascending aorta. However, these guidelines do not account for the mechanism of injury, the localization, or the size of the intimal tear. Conclusion: In this case, the assumption of spontaneous healing with an intact intima was initially supported. However, further developments highlight the importance of clinical and radiological follow-up, regardless of the injury’s mechanism. Relevance for patients: Iatrogenic aortic dissection is a highly complex condition that requires close monitoring and, if necessary, a reassessment of the chosen treatment strategy.
Mx. BIOME: A bioinformatics and big data analysis platform in a data explosion era
Authors: C. Y. Woo Patrick , Lin Yu-Hsi , Huang Shao-Yu , Chen Mei-Hui , Hou Ming-Hon , Huang Chieh-Chen
Published: February 2025

With the development of next-generation sequencing and other technologies, there has been an exponential increase in DNA, RNA, and protein sequences and protein structures in the last two decades, paralleled with the advancement of user-friendly bioinformatics tools. Furthermore, the enormous improvement in computational power and accumulation of massive amounts of data has given rise to the development of big data analysis, which can unveil novel patterns, associations, and trends. In view of the unprecedented biological data explosion, we have recently developed a platform known as Mx. BIOME, which provides a collection of some of the most popular and cutting-edge tools in the fields of bioinformatics and big data analysis. Such a collection would facilitate end-users to identify suitable tools for analyzing their specific datasets. Further studies and reviews on various in silico tools are necessary to compare the advantages and limitations.
WD repeat domain 4 in tumorigenesis: Molecular mechanisms, cancer-type specific roles, and therapeutic potential
Authors: Zou Xun , Tao Ling , Liu Bin
Published: February 2025

WD repeat domain 4 (WDR4) is an essential member of the WD-repeat protein family, known for its regulatory roles in cellular processes critical to cancer development, including RNA modification, protein stability, cell cycle progression, and apoptosis. Studies have shown that WDR4 plays a pivotal role in tumorigenesis across various cancer types, with a particular focus on breast cancer in this study, where its overexpression is closely associated with aggressive tumor characteristics and poorer patient outcomes. As a scaffold protein, WDR4 is involved in N7-methylguanosine tRNA methylation and ubiquitin-mediated protein degradation, thereby regulating RNA stability, protein synthesis, and cell survival. This review provides a comprehensive analysis of WDR4’s molecular mechanisms, its oncogenic functions across different cancer types, and its interactions with other key factors in the tumor microenvironment, further exploring its potential role in tumor progression. As research on WDR4 progresses, we not only gain a deeper understanding of its complex role in tumor biology but also uncover new therapeutic avenues. In particular, the potential of WDR4 as a biomarker and therapeutic target is increasingly recognized. Despite the challenges faced in its clinical application, such as the difficulty in developing targeted therapies and managing side effects, the future prospects of WDR4 in cancer diagnosis and treatment remain promising, and it is expected to emerge as an effective therapeutic target in the near future.
O ensino da Matemática no Ginásio Municipal Américo Souto, Aiquara/BA (1970-1980): enfoque nos livros didáticos
Authors: Santos Zenildo , Campos Costa Lúcio
Published: February 2025

Visando contribuir para um projeto mais amplo, que busca investigar a História da Educação Matemática no Estado da Bahia, este artigo apresenta uma análise de dois livros didáticos de matemática utilizados no início da década de 1970 no Ginásio Municipal Américo Souto (GMAS), o primeiro da cidade de Aiquara - BA. Em particular, buscamos identificar em que medida tais materiais refletiam as tendências em debate no contexto educacional brasileiro, em particular no que se refere aos preceitos defendidos no âmbito do Movimento da Matemática Moderna (MMM), irradiado pelo país desde os anos de 1960, sobretudo a partir das principais capitais. Trata-se de uma pesquisa qualitativa e documental, que analisou um conjunto de fontes escritas e orais. Os resultados encontrados apontam para a presença de elementos do MMM nos livros utilizados no GMAS e que tais materiais constituíram um dos principais instrumentos de difusão das ideias do MMM no contexto do GMAS.
Pengembangan dan Uji Kelayakan Media Pembelajaran 'Roket Terjun Islami' bagi Peserta Didik MI Kelas V
Authors: Mu'iz Kaafin 'Abdul , Musyarofah Nafisatul , Rahman Ananta , Putranta Himawan
Published: February 2025

The aim of this study is to develop and evaluate the feasibility of the Roket Terjun Islami educational media for fifth-grade MI students, aiming to provide an engaging and effective alternative for teachers and enhance classroom learning quality. This research employs a Research and Development approach using the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). Data were collected using questionnaires distributed to fellow students to assess the feasibility and effectiveness of the Roket Terjun Islami educational media. The questionnaire gathered information on design, content, and usability. The collected data were analyzed using descriptive quantitative analysis. Scores from each questionnaire item were summed to obtain the total score, compared to the maximum possible score to calculate the feasibility percentage. The feasibility assessment indicated the following results: the display aspect received 90.38% ("Very Feasible"), media material aspect achieved 95.00% ("Very Feasible"), learning aspect scored 92.85%, and content aspect received 87.85%, both "Very Feasible". These results demonstrate that the Roket Terjun Islami educational media is highly suitable for classroom use.
Nilai-Nilai Pendidikan Dalam Sholat Berjamaah Bagi Santri Putra Di Ponpes Al-Ikhlas
Authors: Yunus Muhammad , Taufik Ahmad , Witjoro Wisnu Adi , Ferdiansyah Ahmad
Published: February 2025

The greatest strength in the country is disciplined youth. Pesantren is more than just teaching religion but also obedience in extraordinary discipline. To make the nation's successor youth great in social, discipline, obedience, membership, and skills in religion. This goal is so that every reader can understand the superiority in togetherness of worship. The method used is qualitative research is descriptive with the type of field research. The result of this study is that pesantren education is a forum for Islamic education and learning for the next generation under the guidance of ustad or kiyai which is followed by students as the main activity. The virtue of prayer is the establishment of friendship and readiness to start praying, getting more multiplied rewards, congregational prayer is rewarded with 27 degrees of goodness. The educational values of congregational prayer are to reflect collective obedience to Allah's commands and affirm solidarity in fulfilling religious obligations. Congregational prayer strengthens the sense of brotherhood. There is a value of blessing. reduce the potential for division, and increase the sense of community togetherness. the value of moral and spiritual education. increase concentration, and improve the quality of worship. Stay away from hypocrisy. As well as practicing discipline.
Konsep Pendidikan Islam Dalam Penguatan Moderasi Beragama
Authors: Arikarani Yesi , Azman Zainal , Aisyah Siti , Ansyah Fadillah Putri , Zakia Kirti Tri Dinigrat
Published: February 2025

In social life, there are certainly many differences that make us have to understand and respect the differences that exist, as is the case in Indonesia, which has a variety of ethnicities, religions, and cultures, so everyone must have an attitude of tolerance towards these things. In the concept of Islamic education, religious moderation must be strengthened because Islam teaches balance and a middle way in all areas of life. This journal was written to increase readers' insight into the importance of moderation. The author hopes that readers can apply the concept of Islamic education to strengthening religious moderation. The author used qualitative research in writing this journal. Qualitative research is descriptive research and tends to use analysis in library research. The data collection process uses references from various journals, articles, and relevant books. Therefore, by strengthening religious moderation, Islamic education can guide people to understand and practice Islamic teachings proportionally without falling into fanaticism, which can trigger conflict and division. There are several concepts of Islamic education that describe an attitude of religious moderation: 1) Tawassuth (choosing the middle way); 2) Tawazun (balance); 3) I’tidal (straight and firm); 4) Tasamuh (tolerance); 5) Musawah (equality); and 6) Shura (consideration). Islamic education can also teach openness and religious diversity so that people understand differences in religion and belief. Therefore, the concept of Islamic education plays a very important role in strengthening religious moderation as a benchmark for Muslims to live a diverse social life in order to create a peaceful social environment.
Typology And Its Influence On The Existence Of Islamic Boarding Schools
Authors: Nafsih Syarifatun
Published: February 2025

One of the efforts to be able to survive and exist by the times, the pesantren comes with various typologies. There are at least three typologies of pesantren that are currently developing, namely salaf, khalaf, and semi-khalaf (combination) pesantren.  The urgency of understanding pesantren typology becomes increasingly critical in facing modern challenges and efforts to optimize the existence of pesantren in the contemporary era. Challenges such as technological advances, globalization, and changes in community demands require pesantren to deeply understand their internal diversity and variation. This study aims to see the extent of the influence of typology on the existence of Islamic boarding schools. With descriptive qualitative research methods, the results show that the existence of boarding schools is influenced by several main factors, namely the role and function of boarding schools in the fields of education, and social, economic, and religious functions. The relevance of boarding school typology to the existence of boarding schools shows that each type has its advantages and challenges that affect its sustainability. Traditional boarding schools that focus on in-depth religious education continue to exist, due to strong support from the community that values the preservation of religious traditions. Modern boarding schools are easier to attract students who want religious education as well as preparation to face the challenges of the modern world. Meanwhile, combination boarding schools can survive by combining the two approaches, providing a holistic education that is relevant to the needs of the times.
Building An Ideal Society From An Islamic Perspective
Authors: Uliyah Taqwatul , Hidayat Rahmat , Fauzi Machfud , Solimin Solimin , Mislawaty Sri Eva
Published: February 2025

The development and existence of Islam until now with its existence is one of the struggles and da'wah movements that always initiate its delivery to the people and nature. Da'wah has started since the time of the Prophet Muhammad Saw until now, with many upheavals and struggles in grounding Islam through da'wah. There are many verses of Allah Swt that discuss da'wah, such as QS. Ali Imran; 104, 110, QS. An Nahl; 125 and many others similar to the phrase da'wah. If we look back at the preaching struggle of Rosulullah Saw while in Mecca, it is essential to try to invite and call the Quraysh to leave the ignorance of their lives to the way of Allah Swt. So that the main pointer of the content of the Prophet's preaching is human servitude to the Oneness of Allah Swt (tauhid). The core of the first da'wah that must be conveyed is about monotheism to Allah Swt and as the foundation of the movement of human dignity. In various ways and efforts, the Prophet's da'wah both in Mecca and Medina had different characteristics of distributing Islamic information. Departing from the understanding of culture, culture, and wisdom of the community that made the Prophet determine different methods in delivering his da'wah. The development of the people, especially the first to instil monotheism to the people, and the second to build a system of society in sharia. Such is the Islamic civilisation from the way of da'wah as Islam that we know today from the Prophet Muhammad Saw struggling to expand his da'wah departing from Mecca and Medina. So that the Prophet's mission of da'wah is to strengthen the internalisation of the ummah and develop relationships with outside the ummah. This means that this is how the teachings of Islam brought by Rosulullah Saw so that it can build an exclusive and moderate da'wah paradigm. And the Prophet Muhammad's da'wah at that time was the main reference for the life of Islamic society in the midst of diverse and complex streams. As well as the foundation of the struggle and movement of da'wah how da'wah should live and last in the midst of a pluralistic society with its heterogeneity.
Peran Mahkamah Konstitusi dalam Menjamin Kedaulatan Hukum di Indonesia
Authors: Anggreni Devi , Fuadi Ahmad , Fitriyani Fitriyani , Al-Kautsar Muhammad Ibnu
Published: February 2025

The Constitutional Court (CC) plays a crucial role in safeguarding the rule of law in Indonesia by ensuring that all laws and governmental policies adhere to the country's constitution. This research explores how the CC functions as an independent guardian of the constitution, balancing power among branches of government, and protecting citizens' rights from potential abuses of power. Through a qualitative approach utilizing literature review, this study analyzes the establishment history, organizational structure, and authority of the CC to conduct judicial reviews on laws deemed unconstitutional.Findings indicate that the CC has played a pivotal role in ensuring legal consistency and constitutional justice in Indonesia. CC decisions, whether through law reviews or constitutional interpretations, have provided the necessary legal certainty for political and economic stability in the country. However, the research also identifies several challenges facing the CC, including political pressures, resource limitations, and the need to enhance compliance with CC decisions among relevant stakeholders. In conclusion, the Indonesian CC holds a vital role in upholding the rule of law by ensuring that the constitution serves as a respected foundation for all within the nation. To maintain relevance amidst evolving social and political dynamics, the CC must continue to enhance its independence as a fair and impartial judicial institution. This study contributes significantly to understanding how the CC contributes to building a democratic and just legal system in Indonesia.
Leveraging Digital tools and ai to Minimize Errors in Clinical Laboratories: A Systematic Review
Authors:   Razan Alsubhi, Amad Khalid Felemban, Nada Mabrok Alnajari, Waleed Saleh Althobaiti, Ibrahim Mohammed Alharbi and Lugain Abduallah Hakami
Published: February 2025

Clinical laboratories are essential to modern healthcare, providing critical diagnostic data that guide patient treatment and management. However, laboratory errors, including misdiagnoses and incorrect test interpretations, can significantly impact patient safety and healthcare outcomes. The integration of digital tools and artificial intelligence (AI) has emerged as a transformative approach to minimizing these errors, enhancing diagnostic accuracy, optimizing workflows, and improving overall laboratory efficiency. This systematic review examines recent advancements in AI-driven diagnostic tools, laboratory automation, data analytics, and digital workflow optimization, highlighting their impact on reducing human errors in clinical laboratories. The review synthesizes findings from peer-reviewed studies published between 2016 and 2025, assessing the effectiveness of AI-based quality control mechanisms, automated laboratory information management systems (LIMS), and predictive analytics in ensuring data integrity and accuracy. While AI and automation present substantial benefits, challenges such as high implementation costs, data security concerns, and resistance to technological adoption remain significant barriers. Future directions include the integration of Internet of Things (IoT)-based monitoring, AI-driven personalized diagnostics, and enhanced regulatory frameworks to support widespread implementation. This review underscores the growing importance of AI and digital tools in revolutionizing laboratory operations, reducing diagnostic errors, and enhancing patient safety.
PERSEPSI KONSUMEN DAN TINGKAT MINAT BELI TERHADAP SIRUP CASCARA CASANDRA BRAND NETISANE: ANALISIS BERDASARKAN PENGEMBANGAN MODEL PLANNED BEHAVIOR
Authors: Hapsari Hepi , Esla Karimah Bella , Eti Suminartika
Published: February 2025

The development of the innovative beverage industry encourages the creation of environmentally friendly products, one of which is cascara casandra syrup from Brand Netisane, which processes coffee skin waste into a useful product that is low in caffeine and high in antioxidants. Despite its great potential, consumer awareness of the advantages of this product is still low. This study aims to examine consumer perceptions and the level of purchase intention towards cascara casandra syrup from Brand Netisane. The variables used in this study include attitudes, subjective norms, perceived behavioral control, environmental concerns, and health awareness. With a quantitative descriptive approach, this study used the census method with all product consumers as respondents. A total of 40 respondents participated in this study, and data were collected through a Likert scale questionnaire distributed online through Goofle Form. The results showed that the purchase interest in cascara syrup reached 82%. Positive perceptions are reflected in attitudes (82.17%), subjective norms (65.5%), perceived behavioral control (85.33%), environmental concerns (84%), and health awareness (82.75%). The main factor influencing purchase intention is health benefits which reached 84.5%.
Corporate Social Responsibility in Limited Liability Companies in National Mining Law
Authors:   Faculty of Law, University of Lampung, Febiola Cahya Putri , Susanti Susi ,   Faculty of Law, University of Lampung, Pratiwi Charine Alya ,   Faculty of Law, University of Lampung, Rumelawanto Fajar Putra Prastina ,   Faculty of Law, University of Lampung
Published: February 2025

Corporate Social Responsibility (CSR) is a social and environmental responsibility that must be implemented by companies in the natural resources sector, including mining, in accordance with Law Number 40 of 2007. This research aims to analyze CSR regulations in Indonesia, especially in the mining industry, and evaluate CSR regulations in the Limited Liability Company Law and Mineral and Coal Law and their derivative regulations. This research also highlights provisions regarding reclamation, post-mining activities, and community empowerment as a form of CSR in the Minerba Law. Using the normative analysis method, it was found that there was a regulatory gap between Minerba Law with PP 78/2010 related to occupational health, which is an important part of social responsibility. Therefore, the implementation of CSR in the mining sector still faces challenges, especially in ensuring that mining companies carry out their obligations consistently. This research recommends harmonization of regulations to strengthen legal certainty and ensure companies implement CSR in a sustainable manner to achieve environmentally sound development and social welfare.
PEDAGOGICAL DIAGNOSTICS IN THE ONLINE LABORATORY EARLY DETECTION OF GIFTEDNESS
Authors:   Samara State University of Social Sciences and Education, Kalinina L.Yu. , Bakshayeva E.V. ,   I. Ya. Yakovlev Chuvash State Pedagogical University
Published: February 2025

The article considers the pedagogical diagnostics of children aged 6-7 years giftedness in an online laboratory, which is a
digital modification of the prototype Laboratory for Early Detection of Giftedness and Career Guidance of Samara State
University of Social Sciences and Education. According to the prototype, the online laboratory "LARNOD" is a "live" game
pedagogical laboratory. At the same time, it has a peculiarity due to its characteristics, according to the theory of distance
learning: the constant separation of the diagnostic laboratory employee and the respondent children, although there are
adult tutors next to the children who help them read assignments and, if necessary, complete them; the leading role of
the research team of the educational organization that develops the laboratory is in planning and preparing diagnostic
tests. and educational materials and providing children with support in the process of activities in the online laboratory;
the use of technical means of communication for communication between laboratory staff and respondents (audio, video,
computer communication), providing children with digital content that stimulates the manifestation of giftedness; the
presence of feedback that promotes the development of a dialogue between the child and adults interested in identifying
his giftedness with the laboratory's research team (sending diagnostic results on request to teachers, parents of preschoolers and the formation of based on the results of a joint strategy for accompanying a tested child on an individual educational route); the practical absence of groups of children during the entire diagnostic and developmental pedagogical
process, i.e., in fact, an individual form of work.
SOCIAL AND ENVIRONMENTAL RESPONSIBILITY IN PROFESSIONAL TRAINING OF STUDENTS OF TECHNICAL UNIVERSITIES: ESSENCE, PRINCIPLES AND METHODS
Authors:   Samara State Technical University, Chekanushkina E.N.
Published: February 2025

The relevance of developing social and environmental responsibility in future engineering and technology specialists
during their training at a university is determined by a combination of various levels of regulatory and legal documentation that specifies requirements for the implementation of professional functions and responsibilities, in particular, in
the field of compliance with environmental safety rules and regulations, social responsibility for decision-making and
their results in accordance with the types of engineering activities in the field of environmental protection. In this regard,
the article pays significant attention to the analysis of the essence of the definition of "social and environmental responsibility of technical specialists", as well as environmental training in order to develop social and environmental responsibility in future technical specialists as a significant professional and personal quality. The leading approach to the study
is based on the theoretical analysis of the problem of social and environmental responsibility in the professional activities
of technical specialists and the importance of its formation in students at the stage of training at a university. As a result
of the study, the essence of the concept of "social and environmental responsibility" is determined and its definition is
presented. The main approaches (competency-modular, interdisciplinary, systemic, holistic, fragmentary-introvertive,
personality-oriented), principles (greening, scientific, regional, activity, continuity and systematicity, universality) and
methods (case-study, reflexive, project and others) of the formation of social and environmental responsibility of future
technical specialists are identified and substantiated. The active teaching methods implemented in the educational process in the disciplines: introduction to the specialty, philosophy, psychology, law, project activities contribute to the
development of social and environmental responsibility necessary for graduates in their professional activities when
solving problems inextricably linked with the environment and society.
REPRODUCTION OF WORDPLAY AS THE IMPORTANT ASPECT OF TRANSLATION
Authors:   Samara State Technical University, Zhuravlev A.P.
Published: February 2025

The article deals with the issue of the wordplay reproduction in the translation of literary texts from English into Russian.
The article analyzes the notion of wordplay as s powerful tool able not only to express the meaning nuances but also to
produce a particular effect on a reader. The article discusses some of the most commonly used types of wordplay and
analyzes the ways of creating wordplay, as well as some methods used to reproduce it in the translated text. It is noted
that one of the main problems of reproduction of wordplay is preserving both its meaning and its form. Analysis of real
cases of wordplay reproduction serves as a tool to form certain competencies required for successful completion of the
translation studies course. In conclusion, there listed a number skills and abilities the translator needs to reproduce wordplay in the most efficient manner. Another conclusion drawn is that the reproduction of wordplay to its full extent is not
always possible due to some objective causes
FROM CLASSROOM TO ENTREPRENEURSHIP: ASSESSING KNOWLEDGE AND SKILLS FOR AGRICULTURAL SELF-EMPLOYMENT AMONG SUA’S 2023/24 FINALYEAR STUDENTS
Authors: S. Silvia Sanka, , A. Kyaruzi Ahmad , M. Madaha Rasel
Published: February 2025

This study investigates the preparedness of final-year undergraduate students at Sokoine University of Agriculture (SUA) for agricultural self-employment, with a focus on their perceived knowledge, technical skills, and soft skills. A structured survey was administered to 202 randomly selected students to assess their understanding of essential competencies for entrepreneurial success in agriculture. A t-test analysis identified gender differences, with male students reporting higher confidence than female students (p = 0.02). The findings reveal significant gaps in students' perceived knowledge, particularly in business management, financial planning, and marketing, with only 25% of students expressing confidence in these areas Regression analysis indicated that exposure to internships and entrepreneurship training positively impacted students' proficiency in these areas. Participation in internships and entrepreneurship workshops was associated with enhanced selfreported preparedness (p = 0.01 for both), highlighting the value of experiential learning. Technical skills, including crop and livestock management, business acumen, and technological literacy, showed moderate proficiency, but over 45% of students lacked proficiency in financial management, and more than 50% rated their technological literacy as low. Marketing and value chain management skills were also underdeveloped, with only 18% reporting high proficiency. Soft skills, such as communication, problem-solving, teamwork, and leadership, were assessed, with students showing confidence in communication and teamwork, while younger students (19-22 years) reported lower problem-solving skills. The study concludes that students possess foundational agricultural skills but require further training in business management, financial literacy, and technological adoption. The study recommends integrating business-focused modules, expanding technological training, and enhancing experiential learning opportunities to better prepare students for agricultural self-employment.
A Comparative Study to Assess the Nutritional Status of Preschool Childern in Selected Rural and Urban Areas, Of Fatehgarh Sahib, Punjab
Authors: Monika  , Prabhjot Singh  , Dilpreet Kaur
Published: February 2025

ABSTRACTMalnutrition is like an iceberg, most people in the developing countries live under the burden of malnutrition. Pregnant women, nursing mother and children are particularly vulnerable to the effects of malnutrition. Malnutrition is widely prevalent among weaned infants and preschool children. The aim of the present study is to assess the nutritional status of urban and ruralpreschool children.OBJECTIVES (1) To Assess the nutritional status of rural area preschool children. (2) To assess the nutritional status of urban area preschool children. (3) To compare nutritional status among rural and urban area preschool children. (4) To determine associations between nutritional status of rural and urban preschool children with selected socio demographic variables. (5) To develop pamphlet regarding recommended daily allowance for preschool children. DESIGN: Non experimental comparative design was selected for the study. APPROACH: A descriptive survey approach was used. SUBJECTS: The participants were 120 preschool children, 60 from saunti (rural) and 60 from gobindgarh (urban), Punjab. METHOD: A purposive sampling technique was used to select the sample for study. DATA COLLECTION TOOL: An interview schedule and observation check list was used to collect data from the subjects. DATAANALYSIS: The obtained data was analysed using descriptive and inferential statistics and interpreted in terms of objectives and hypothesis of the study. The level of significance was set 0.05 levels. RESULTS:The researcher found the rural preschool children nutritional status 66.7% (40) had moderate nutritional status and 33.3% (20) had adequate nutritional status. Regarding urban preschool children nutritional status, 30.0% (18) had moderate nutritional status, and 70.0% (42) had adequate nutritional status. CONCLUSION: From the analysis report the researcher concluded that there is significant difference between nutritional status of urban and rural preschool children and distributed pamphlet regarding RDA to mothers of preschool children with a view to improve the nutritional status.
Interference from semantically distracting sounds in action scene search
Authors: Maezawa Tomoki , Kiyosawa Miho , Kawahara Jun I.
Published: February 2025

Research on visual searching has highlighted the role of crossmodal interactions between semantically congruent visual and auditory stimuli. Typically, such sounds facilitate performance. Conversely, semantically incongruent sounds may impair visual search efficiency for action scenes, though consensus has yet to be reached. This study investigated whether interference effects occur within the action-scene search paradigm. Participants performed a search task involving four simultaneously presented video stimuli, accompanied by one of three sound conditions: sound congruent with the target, congruent with a distractor, or a control sound. Auditory interference was observed, though it was relatively weak and varied across conditions rather than being simply present or absent. The observed variability in interference effects may align with the established view that observers typically ignore semantic distractor information in goal-directed searches, except in cases where the strength of target designation is compromised. These findings offer insights into the complex interplay between auditory and visual stimuli in action scene searches, suggesting that these underlying mechanisms may also apply to other paradigms, such as those involving conventional real object searches.
Bilgi Toplumunda Üniversitelerin Yeniden İnşası (Dijitalleşme, Yenilik ve Kalite Güvencesi)
Authors: Samur Serdar
Published: February 2025

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Molecular diversity of the reactions of MBH carbonates of isatins and various nucleophiles
Authors: Xiao Zi-Ying , Sun Jing , Yan Chao-Guo
Published: February 2025

In this paper, the nucleophilic substitution reactions of various N- and P-containing nucleophiles to MBH carbonates of isatins were investigated. Diverse functionalized 3-substituted oxindole derivatives were successfully prepared in satisfactory yields and with high diastereoselectivity. In addition, the base-promoted dimerization of MBH carbonates of isatin afforded the ethylene-bridged bis(3-methylene)oxindole derivatives with nearly 4:1 diastereomeric ratios. The relative configurations of the various polycyclic compounds were clearly elucidated by determination of several single crystal structures.
Diseño y manufactura de carrocería de vehículo eléctrico con paneles solares para uso urbano
Authors: Reséndiz Barrón Abisai Jaime , Ramos Pérez Miguel Aarón , Salas Flores Alejandro , García Rodriguez Francisco Javier
Published: February 2025

La industria automotriz se enfrenta a la urgente necesidad de reducir el impacto ambiental y mitigar el cambio climático. Una alternativa en esta lucha es el uso del Vehículo Eléctrico (VE) urbano, un vehículo compacto de baja velocidad y más económico. Uno de los grandes desafíos es la integración de paneles solares en la carrocería del VE para mejorar su autonomía energética. En este trabajo, se muestra el diseño de la carrocería de un VE ultra compacto, realizado en Solid Works y renderizado con software 3D Blender. Se estima el área irradiada por el sol, con la finalidad de colocar paneles solares flexibles sobre el capó y el toldo del VE, y conocer su contribución a la autonomía energética del VE. Finalmente, se describe el proceso de manufactura de la carrocería tipo monocasco en fibra de vidrio. Los conceptos anteriores, persiguen el objetivo de hacer el VE más rentable y práctico para la movilidad urbana.  Los planos obtenidos en solid works proporcionan las medidas y detalles, tanto para el cálculo energético de exposición solar, como  para el porceso de fabricación en fibra de vidrio, que comprende desde un modelo en unicel,  hasta el prototipo de carrocería de acuerdo al diseño aerodinámico final. En el proceso se destaca la utilización de barro en el modelado del VE, en lugar de utilizar arcilla automotriz, que es mucho más costosa y contaminante que el barro.
Internalization of Religious Character Values Through Himpunan Putusan Tarjih Muhammadiyah Learning in College Student Boarding School
Authors: Ridho Abiyyul , Mustofa Triono Ali
Published: February 2025

This study aims to explain how to internalize religious character values through learning Himpunan Putusan Tarjih Muhammadiyah at the KH. Mas Mansur student boarding school, Universitas Muhammadiyah Surakarta. This research utilizes a qualitative method with a phenomenological approach. The research data collection technique was performed through interviews, observation, and documentation. Data analysis was carried out based on the analysis initiated by Miles and Huberman, namely data reduction, data presentation, conclusion drawing, and verification. The data is summarized and then juxtaposed with supporting theories, discourses, and research. The research results show that five religious character values are internalized through Himpunan Putusan Tarjih learning to mahasantri: collaboration, independence, hard work, honesty, and brotherhood. The strategy of internalizing religious character values in Himpunan Putusan Tarjih uses the lecture method, demonstration method, and problem-based learning through discussion. Furthermore, some obstacles were still encountered in its implementation, namely the limited duration of learning and the lack of enthusiasm and activeness of the mahasantri in learning, so learning did not seem very conducive. The supporting aspects that influence the internalization of religious character values are the natural instincts of individuals, habits that are practiced repeatedly, and the good influence of the environment and people around them. As for the aspects that obstruct the process, namely the lack of awareness of mahasantri, the use of technology, and the lack of management supervision. Therefore, it is essential to have the role and responsibility of boarding school organizers in overcoming these challenges by developing a comprehensive understanding of religious character, criticism and suggestions for various attitudes and routines of mahasantri, intensive evaluation through an efficient approach, and the role of boarding school with surrounding people in maintaining good relations and striving to increase the success of internalization in various aspects of mahasantri life.