bluuebunny/crossref_metadata_2025 huggingface dataset:
Flavour mixing transport theory and resonant leptogenesis
Authors: Jukkala Henri , Kainulainen Kimmo , Rahkila Pyry M.
Published: September 2021

Abstract

We derive non-equilibrium quantum transport equations for flavour-mixing fermions. We develop the formalism mostly in the context of resonant leptogenesis with two mixing Majorana fermions and one lepton flavour, but our master equations are valid more generally in homogeneous and isotropic systems. We give a hierarchy of quantum kinetic equations, valid at different approximations, that can accommodate helicity and arbitrary mass differences. In the mass-degenerate limit the equations take the familiar form of density matrix equations. We also derive the semiclassical Boltzmann limit of our equations, including the CP-violating source, whose regulator corresponds to the flavour coherence damping rate. Boltzmann equations are accurate and insensitive to the particular form of the regulator in the weakly resonant case ∆m » Γ, but for ∆m ≲ Γ they are qualitatively correct at best, and their accuracy crucially depends on the form of the CP-violating source.
Dissipation in holographic superfluids
Authors: Donos Aristomenis , Kailidis Polydoros , Pantelidou Christiana
Published: September 2021

Abstract

We study dissipation in holographic superfluids at finite temperature and zero chemical potential. The zero overlap with the heat current allows us to isolate the physics of the conserved current corresponding to the broken global U(1). By using analytic techniques we write constitutive relations including the first non-trivial dissipative terms. The corresponding transport coefficients are determined in terms of thermodynamic quantities and the black hole horizon data. By analysing their behaviour close to the phase transition we show explicitly the breakdown of the hydrodynamic expansion. Finally, we study the pseudo-Goldstone mode that emerges upon introducing a perturbative symmetry breaking source and we determine its resonant frequency and decay rate.
Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis
Authors: Umeda Mai , Tominaga Takeichiro , Kozuma Kazuya , Kitazawa Hidefumi , Furushima Daisuke , Hibi Masanobu , Yamada Hiroshi
Published: September 2021

Purpose

Gargling with tea has protective effects against influenza infection and upper respiratory tract infection (URTI). To evaluate if tea and tea catechin consumption has the same protective effects as gargling with tea, we performed a systematic review and meta-analysis.

Methods

We performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases. The search provided six randomized controlled trials (RCTs) and four prospective cohort studies (n = 3748). The quality of each trial or study was evaluated according to the Cochrane risk-of-bias tool or Newcastle–Ottawa Scale. We collected data from publications meeting the search criteria and conducted a meta-analysis of the effect of tea gargling and tea catechin consumption for preventing URTI using a random effects model.

Results

Tea gargling and tea catechin consumption had significant preventive effects against URTI (risk ratio [RR] = 0.74, 95% confidence interval [CI] 0.64–0.87). In sub-analyses, a significant preventive effect was observed by study type (prospective cohort study: RR = 0.67, 95% CI 0.50–0.91; RCT: RR = 0.79, 95% CI 0.66–0.94) and disease type (influenza: RR = 0.69, 95% CI 0.58–0.84; acute URTI: RR = 0.78, 95% CI 0.62–0.98). Both gargling with tea and consuming tea catechins effectively protected against URTI (tea and tea catechins consumption: RR = 0.68, 95% CI 0.52–0.87; tea gargling: RR = 0.83, 95% CI 0.72–0.96).

Conclusion

Our findings suggest that tea gargling and tea catechin consumption may have preventive effects against influenza infection and URTI. The potential effectiveness of these actions as non-pharmaceutical interventions, however, requires further investigation.
Aberrant right subclavian artery as soft marker in the diagnosis of trisomy 21 during the first trimester of pregnancy
Authors: Martínez-Payo Cristina , Suanzes Elena , Gómez-Manrique Ana , Arranz Alexandra , Pérez-Medina Tirso
Published: September 2021

Purpose

Aberrant right subclavian artery is an anatomical variation with a prevalence of around 0.5–1.5% of the general population, being more frequently found among people with chromosomopathies, especially, trisomy 21. Despite being an anatomical finding, and thus, constant through the whole pregnancy, its value in the diagnosis of aneuploidies during the first trimester of pregnancy has been little studied. The aim of this study is to evaluate the reliability of the first-trimester ultrasound in the diagnosis of ARSA and its utility in the early diagnosis of aneuploidies.

Methods

This was a descriptive, observational, cross-sectional study that included all fetuses with sonographic diagnosis of ARSA between 2011 and 2018.

Results

There were 257 cases of ARSA diagnosed. The first-trimester ultrasound showed the following results in the detection of ARSA: sensitivity of 68% (CI 95% 60.8%–74.5%), specificity of 99.9% (CI 95% 99.9%–100%), positive predictive value of 93.7% (CI 95% 88.1%–96.8%), and negative predictive value of 99.6% (CI 95% 99.5%–99.7%). Due to the presence of ARSA, two cases of trisomy 21, that would have been missed in the first trimester, were diagnosed, using ARSA as a soft marker and modifying the risk obtained by the combined screening as part of the genetic sonogram of the first trimester.

Conclusions

ARSA visualization during the first-trimester ultrasound is trustworthy and it can improve the detection of trisomy 21 in some cases of aneuploidy missed during the combined screening of the first trimester.
Quantitative evidence of suppressed TMEM119 microglial immunohistochemistry in fatal morphine intoxications
Authors: Bohnert Simone , Georgiades Kosmas , Monoranu Camelia-Maria , Bohnert Michael , Büttner Andreas , Ondruschka Benjamin
Published: September 2021

The aim of this pilot study was to investigate the diagnostic potential of TMEM119 as a useful microglia-specific marker in combination with immunostainings for phagocytic function and infiltrating capacity of monocytes in cases of lethal monosubstance intoxications by morphine (MOR), methamphetamine (METH), and of ethanol-associated death (ETH) respectively. Human brain tissue samples were obtained from forensic autopsies of cases with single substance abuse (MOR, n = 8; ETH, n = 10; METH, n = 9) and then compared to a cohort of cardiovascular fatalities as controls (n = 9). Brain tissue samples of cortex, white matter, and hippocampus were collected and stained immunohistochemically with antibodies against TMEM119, CD68KiM1P, and CCR2. We could document the lowest density of TMEM119-positive cells in MOR deaths with highly significant differences to the control densities in all three regions investigated. In ETH and METH deaths, the expression of TMEM119 was comparable to cell densities in controls. The results indicate that the immunoreaction in brain tissue is different in these groups depending on the drug type used for abuse.
Improving the safety of outpatient parenteral antimicrobial therapy for patients with solid tumors
Authors: Robins Alison , Dishner Emma , McDaneld Patrick , Rowan Meagan , Bartek Jalen , Jiang Ying , Adachi Javier , Dailey Garnes Natalie J. M.
Published: September 2021

Background and objectives

Outpatient parenteral antimicrobial therapy (OPAT) for infections has been in use for nearly 40 years, and although it has been found safe and efficacious, its use has been studied primarily among otherwise healthy patients. We aimed to develop and evaluate an OPAT program for patients with cancer, particularly solid tumors.

Methods

We implemented multiple quality improvement interventions between June 2018 and January 2020. We retrospectively and prospectively collected data on demographics, the completeness of infectious diseases (ID) physician consultation notes, rates of laboratory test result monitoring, ID clinic follow-up, and 30-day outcomes, including unplanned OPAT-related readmissions, OPAT-related emergency center visits, and deaths.

Results

Completeness of ID provider notes improved from a baseline of 77 to 100% (p < .0001) for antimicrobial recommendations, 75 to 97% (p < .0001) for follow-up recommendations, and 19 to 98% (p < .0001) for laboratory test result monitoring recommendations. Completion of laboratory tests increased from a baseline rate of 24 to 56% (p = .027). Thirty-day unplanned OPAT-related readmission, ID clinic follow-up, 30-day emergency center visit, and death rates improved without reaching statistical significance.

Conclusions

Sustained efforts, multiple interventions, and multidisciplinary engagement can improve laboratory test result monitoring among solid tumor patients discharged with OPAT. Although demonstrating a decrease in unplanned readmissions through institution of a formal OPAT program among patients with solid malignancies may be more difficult compared with the general population, the program may still result in improved safety.
GUASOM: an adaptive visualization tool for unsupervised clustering in spectrophotometric astronomical surveys
Authors: Álvarez M. A. , Dafonte C. , Manteiga M. , Garabato D. , Santoveña R.
Published: September 2021

We present an adaptive visualization tool for unsupervised classification of astronomical objects in a Big Data context such as the one found in the increasingly popular large spectrophotometric sky surveys. This tool is based on an artificial intelligence technique, Kohonen’s self-organizing maps, and our goal is to facilitate the analysis work of the experts by means of oriented domain visualizations, which is impossible to achieve by using a generic tool. We designed a client-server that handles the data treatment and computational tasks to give responses as quickly as possible, and we used JavaScript Object Notation to pack the data between server and client. We optimized, parallelized, and evenly distributed the necessary calculations in a cluster of machines. By applying our clustering tool to several databases, we demonstrated the main advantages of an unsupervised approach: the classification is not based on pre-established models, thus allowing the “natural classes” present in the sample to be discovered, and it is suited to isolate atypical cases, with the important potential for discovery that this entails. Gaia Utility for the Analysis of self-organizing maps is an analysis tool that has been developed in the context of the Data Processing and Analysis Consortium, which processes and analyzes the observations made by ESA’s Gaia satellite (European Space Agency) and prepares the mission archive that is presented to the international community in sequential periodic publications. Our tool is useful not only in the context of the Gaia mission, but also allows segmenting the information present in any other massive spectroscopic or spectrophotometric database.
A fractional Hadamard formula and applications
Authors: Djitte Sidy Moctar , Fall Mouhamed Moustapha , Weth Tobias
Published: September 2021

We derive a shape derivative formula for the family of principal Dirichlet eigenvalues $$\lambda _s(\Omega )$$

λ
s

(
Ω
)

of the fractional Laplacian $$(-\Delta )^s$$

(
-
Δ
)

s

associated with bounded open sets $$\Omega \subset \mathbb {R}^N$$

Ω
⊂

R

N

of class $$C^{1,1}$$

C

1
,
1

. This extends, with a help of a new approach, a result in Dalibard and Gérard-Varet (Calc. Var. 19(4):976–1013, 2013) which was restricted to the case $$s=\frac{1}{2}$$

s
=

1
2

. As an application, we consider the maximization problem for $$\lambda _s(\Omega )$$

λ
s

(
Ω
)

among annular-shaped domains of fixed volume of the type $$B\setminus \overline{B}'$$

B
\

B
¯

′

, where B is a fixed ball and $$B'$$

B
′

is ball whose position is varied within B. We prove that $$\lambda _s(B\setminus \overline{B}')$$

λ
s

(
B
\

B
¯

′

)

is maximal when the two balls are concentric. Our approach also allows to derive similar results for the fractional torsional rigidity. More generally, we will characterize one-sided shape derivatives for best constants of a family of subcritical fractional Sobolev embeddings.
On n-superharmonic functions and some geometric applications
Authors: Ma Shiguang , Qing Jie
Published: September 2021

In this paper we study asymptotic behaviors of n-superharmonic functions at singularity using the Wolff potential and capacity estimates in nonlinear potential theory. Our results are inspired by and extend [6] of Arsove–Huber and [63] of Taliaferro in 2 dimensions. To study n-superharmonic functions we use a new notion of thinness in terms of n-capacity motivated by a type of Wiener criterion in [6]. To extend [63], we employ the Adams–Moser–Trudinger’s type inequality for the Wolff potential, which is inspired by the inequality used in [15] of Brezis–Merle. For geometric applications, we study the asymptotic end behaviors of complete conformally flat manifolds as well as complete properly embedded hypersurfaces in hyperbolic space. These geometric applications seem to elevate the importance of n-Laplace equations and make a closer tie to the classic analysis developed in conformal geometry in general dimensions.
Experimental method for identifying constitutive parameters of rolling resistance between particles in discrete element method
Authors: Wang Dianrui , Gao Zhengguo , Zhang Yajun , Dong Pengkun
Published: September 2021

A method to identify the parameters of rolling resistance between particles in the discrete element method is proposed in this paper. Experiments revealed that a free rolling particle would swing back and forth marginally before it stops. We assume that the restoring force of the swing is mainly rolling resistance. An optical experimental system was designed to obtain the rolling resistance in the DEM model. A method to identify the parameters using the time history curve of the swing is proposed. We measured the time history of the angular displacement of cylindrical samples made of rubber and aluminum. In addition, the rolling stiffness and damping coefficients were identified. The identified parameters were applied to the discrete element model to simulate the experimental process. The results show that the time-history curve of swing obtained by DEM is in good agreement with the experimental curve. This verifies that the particle swings back and forth because of rolling resistance and that the parameters of the rolling resistance model can be determined by this experimental method
Welfare and research and development incentive effects of uniform and differential pricing schemes
Authors: Gnecco Giorgio , Pammolli Fabio , Tuncay Berna
Published: September 2021

This paper is about the application of optimization methods to the analysis of three pricing schemes adopted by one manufacturer in a two-country model of production and trade. The analysis focuses on pricing schemes—one uniform pricing scheme, and two differential pricing schemes—for which there is no competition coming from the so-called parallel trade. This term denotes the practice of buying a patented product like a medicine in one market at one price, then re-selling it in a second so-called gray market at a higher price, on a parallel distribution chain where it competes with the official distribution chain. The adoption of pricing schemes under which parallel trade does not arise can prevent the occurrence of its well-documented negative effects. In the work, a comparison of the optimal solutions to the optimization problems modeling the three pricing schemes is performed. More specifically, conditions are found under which the two differential pricing schemes are more desirable from several points of view (e.g., incentive for the manufacturer to do Research and Development, product accessibility, global welfare) than the uniform pricing scheme. In particular, we prove that, compared to the uniform pricing scheme, the two differential pricing schemes increase the incentive for the manufacturer to invest in Research and Development. We also prove that they serve both countries under a larger range of values for the relative market size, making the product more accessible to consumers in the lower price country. Moreover, we provide a sufficient condition under which price discrimination is more efficient from a global welfare perspective than uniform pricing. The analysis applies in particular to the case of the European Single Market for medicines. Compared to other studies, our work takes into account also the possible presence in all the optimization problems of a positive constant marginal cost of production, showing that it can have non-negligible effects on the results of the analysis. As an important contribution, indeed, our analysis clarifies the conditions—which have been overlooked in the literature about the mechanisms adopted to prevent parallel trade occurrence—that allow/do not allow one to neglect the presence of this factor. Such conditions are related, e.g., to the comparison between the positive constant marginal cost of production, the parallel trade cost per-unit, and the maximal price that can be effectively charged to the consumers in the lower price country.
Comprehensive registry of esophageal cancer in Japan, 2014
Authors: Watanabe Masayuki , Toh Yasushi , Ishihara Ryu , Kono Koji , Matsubara Hisahiro , Murakami Kentaro , Muro Kei , Numasaki Hodaka , Oyama Tsuneo , Ozawa Soji , Saeki Hiroshi , Tanaka Koji , Tsushima Takahiro , Ueno Masaki , Uno Takashi , Yoshio Toshiyuki , Usune Shiyori , Takahashi Arata , Miyata Hiroaki ,   The Registration Committee for Esophageal Cancer of the Japan Esophageal Society
Published: September 2021

Background

The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes annually.

Methods

We analyzed the data of patients who had visited the participating hospitals in 2014. We collected the data with a web-based data collection system using the National Clinical Database. We used the Japanese Classification of Esophageal Cancer 10th edition by JES and the TNM classification 7th edition by the Union of International Cancer Control (UICC) for cancer staging.

Results

A total of 9026 cases were registered from 344 institutions in Japan. Squamous cell carcinoma and adenocarcinoma accounted for 87.9% and 7.1%, respectively. The 5-year survival rates of patients treated using endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, and esophagectomy were 87.1%, 33.7%, 25.3%, and 59.3%, respectively. Esophagectomy was performed in 5204 cases. Concerning the approach used for esophagectomy, 48.1% of the cases were treated thoracoscopically. The operative mortality (within 30 days after surgery) was 0.75%, and the hospital mortality was 2.0%. The survival curves showed an excellent discriminatory ability both in the clinical and pathologic stages by the JES system. The survival of pStage IV was better than IIIC in the UICC system, because pStage IV included the patients with supraclavicular lymph-node metastasis (M1 LYM).

Conclusion

We hope that this report contributes to improving all aspects of diagnosing and treating esophageal cancer in Japan.
Reliability of Addenbrooke's Cognitive Examination III in differentiating between dementia, mild cognitive impairment and older adults who have not reported cognitive problems
Authors: Potts C. , Richardson J. , Bond R. B. , Price R. K. , Mulvenna M. D. , Zvolsky P. , Harvey M. , Hughes C. F. , Duffy F.
Published: September 2021

Diagnosing dementia can be challenging for clinicians, given the array of factors that contribute to changes in cognitive function. The Addenbrooke’s Cognitive Examination III (ACE-III) is commonly used in dementia assessments, covering the domains of attention, memory, fluency, visuospatial and language. This study aims to (1) assess the reliability of ACE-III to differentiate between dementia, mild cognitive impairment (MCI) and controls and (2) establish whether the ACE-III is useful for diagnosing dementia subtypes. Client records from the Northern Health and Social Care Trust (NHSCT) Memory Service (n = 2,331, 2013–2019) were used in the analysis including people diagnosed with Alzheimer’s disease (n = 637), vascular dementia (n = 252), mixed dementia (n = 490), MCI (n = 920) and controls (n = 32). There were significant differences in total ACE-III and subdomain scores between people with dementia, MCI and controls (p < 0.05 for all), with little overlap between distribution of total ACE-III scores (< 39%) between groups. The distribution of total ACE-III and subdomain scores across all dementias were similar. There were significant differences in scores for attention, memory and fluency between Alzheimer’s disease and mixed dementia, and for visuospatial and language between Alzheimer’s disease–vascular dementia (p < 0.05 for all). However, despite the significant differences across these subdomains, there was a high degree of overlap between these scores (> 73%) and thus the differences are not clinically relevant. The results suggest that ACE-III is a useful tool for discriminating between dementia, MCI and controls, but it is not reliable for discriminating between dementia subtypes. Nonetheless, the ACE-III is still a reliable tool for clinicians that can assist in making a dementia diagnosis in combination with other factors at assessment.
Retrospective Experiences of First-Episode Psychosis Treatment Under Open Dialogue-Based Services: A Qualitative Study
Authors: Bergström Tomi , Seikkula Jaakko , Holma Juha , Köngäs-Saviaro Päivi , Taskila Jyri J. , Alakare Birgitta
Published: September 2021

Open Dialogue (OD) is an integrated approach to mental health care, which has demonstrated promising outcomes in the treatment of first-episode psychosis (FEP) in Finnish Western Lapland region. However, little is known how treatment under OD is retrospectively experienced by the service users themselves. To address this, twenty participants from the original Western Lapland research cohort diagnosed with psychosis (F20–F29) were asked about their treatment of FEP, initiated under OD 10–23 years previously. Thematic analysis was used to explore how the treatment was experienced. Most participants viewed network treatment meetings as an important part of their treatment, as they enabled interactions with other people and the chance to go through difficult experiences. A minority of the participants had mixed experiences regarding family involvement and immediate home visits. OD may have the potential to promote therapeutic relationships, but replications from other catchment areas are needed.
ZIPLAS: Zooplankton Index for Polish Lakes’ Assessment: a new method to assess the ecological status of stratified lakes
Authors: Ochocka Agnieszka
Published: September 2021

Zooplankton is widely recognized as a key component of pelagic ecosystems and forms the basis for major trophic webs. Although zooplankton has often been used as an indicator of trophic state, it has not been included as an obligatory element of the water assessment systems compliant with the Water Framework Directive. This article introduces the Zooplankton Index for Polish Lakes’ Assessment (ZIPLAS) as a new method to assess the ecological status of stratified lakes based on the zooplankton community. The ZIPLAS evaluates three aspects of zooplankton communities, namely, taxonomic composition and abundance, diversity of the zooplankton community, and stressor-sensitive species, which are combined into a multimetric index. Following are the metrics used to compose multimetric ZIPLAS: percentage share of the Rotifer species indicative of high trophy in the indicative group’s number (IHTROT; %), ratio of Calanoida to Cyclopoida individual numbers (CA/CY), percentage of tecta form in the population of Keratella cochlearis (TECTA; %), Margalef’s index (d), and zooplankton abundance (NZOL; ind./L). ZIPLAS responds clearly to eutrophication indicators—the strongest with Secchi disc visibility (Spearman’s rank correlation R = 0.86) and slightly weaker with the expressed by total phosphorus (R = -0.74), total nitrogen (R = 0.68) and the catchment pressure expressed by the nutrient loads generated by different types of land use (R = -0.58).
Distinguishing Disadvantage from Ill-Being in the Capability Approach
Authors: Östlund Sebastian
Published: September 2021

Central capabilitarian theories of well-being focus exclusively on actual opportunities to attain states of being and doing that people have reason to value. Consequently, these theories characterise ill-being and disadvantage as deprivations of such opportunities and attainments. However, some well-being aspects are inherently negative. They make up the difference between not being well and being unwell in that they constitute ill-being. While disadvantage can be plausibly captured by deprivations, ill-being cannot be fully captured by them. I support this claim by analysing cases involving inherently negative aspects of homelessness that are not mere deprivations of opportunities to attain beings and doings that people have reason to value. I conclude that ill-being is not only about what one cannot be and do, but also about one’s enduring, and opportunities to avoid, negative beings and doings. Theories and policies should reflect this to get things right, and to do right by people.
Pandemic-type failures in multivariate Brownian risk models
Authors: Dȩbicki Krzysztof , Hashorva Enkelejd , Kriukov Nikolai
Published: September 2021

Modelling of multiple simultaneous failures in insurance, finance and other areas of applied probability is important especially from the point of view of pandemic-type events. A benchmark limiting model for the analysis of multiple failures is the classical d-dimensional Brownian risk model (Brm), see Delsing et al. (Methodol. Comput. Appl. Probab. 22(3), 927–948 2020). From both theoretical and practical point of view, of interest is the calculation of the probability of multiple simultaneous failures in a given time horizon. The main findings of this contribution concern the approximation of the probability that at least k out of d components of Brm fail simultaneously. We derive both sharp bounds and asymptotic approximations of the probability of interest for the finite and the infinite time horizon. Our results extend previous findings of Dȩbicki et al. (J. Appl. Probab. 57(2), 597–612 2020) and Dȩbicki et al. (Stoch. Proc. Appl. 128(12), 4171–4206 2018).
Abelian permutation groups with graphical representations
Authors: Grech Mariusz , Kisielewicz Andrzej
Published: September 2021

In this paper we characterize those automorphism groups of colored graphs and digraphs that are abelian as abstract groups. This is done in terms of basic permutation group properties. Using Schur’s classical terminology, what we provide is characterizations of the classes of 2-closed and $$2^*$$

2
∗

-closed abelian permutation groups. This is the first characterization concerning these classes since they were defined.
Metabolite patterns link diet, obesity, and type 2 diabetes in a Hispanic population
Authors: Parnell Laurence D. , Noel Sabrina E. , Bhupathiraju Shilpa N. , Smith Caren E. , Haslam Danielle E. , Zhang Xiyuang , Tucker Katherine L. , Ordovas Jose M. , Lai Chao-Qiang
Published: September 2021

Introduction

Obesity is a precursor of type 2 diabetes (T2D).

Objectives

Our aim was to identify metabolic signatures of T2D and dietary factors unique to obesity.

Methods

We examined a subsample of the Boston Puerto Rican Health Study (BPRHS) population with a high prevalence of obesity and T2D at baseline (n = 806) and participants (without T2D at baseline) at 5-year follow-up (n = 412). We determined differences in metabolite profiles between T2D and non-T2D participants of the whole sample and according to abdominal obesity status. Enrichment analysis was performed to identify metabolic pathways that were over-represented by metabolites that differed between T2D and non-T2D participants. T2D-associated metabolites unique to obesity were examined for correlation with dietary food groups to understand metabolic links between dietary intake and T2D risk. False Discovery Rate method was used to correct for multiple testing.

Results

Of 526 targeted metabolites, 179 differed between T2D and non-T2D in the whole sample, 64 in non-obese participants and 120 unique to participants with abdominal obesity. Twenty-four of 120 metabolites were replicated and were associated with T2D incidence at 5-year follow-up. Enrichment analysis pointed to three metabolic pathways that were overrepresented in obesity-associated T2D: phosphatidylethanolamine (PE), long-chain fatty acids, and glutamate metabolism. Elevated intakes of three food groups, energy-dense takeout food, dairy intake and sugar-sweetened beverages, associated with 13 metabolites represented by the three pathways.

Conclusion

Metabolic signatures of lipid and glutamate metabolism link obesity to T2D, in parallel with increased intake of dairy and sugar-sweetened beverages, thereby providing insight into the relationship between dietary habits and T2D risk.
The Kinetics of Two-Step Ellagitannin Extraction from the By-products of Selected Processed Fruits of the family Rosaceae
Authors: Milczarek Agnieszka , Sójka Michał , Klewicki Robert
Published: September 2021

The paper presents the kinetics of two-step ellagitannin (ET) extraction with an aqueous acetone solution from two technological types of pomace from selected berry fruits of the Rosaceae family. ETs were identified and quantified using HPLC–MS and HPLC–DAD. The results revealed the extraction kinetics of total ETs, their high and low molecular weight fractions (≤ 1569 Da and > 1569 Da), and individual ETs characteristic of the examined fruits. ET extraction proceeded at a faster rate in the first step, regardless of the tested pomace. For all pomace variants, the mean extraction half time t1/2 was 48 min in the first step and 70 min in the second step. The fruit species and the technological type of pomace were not found to exert a definite effect on the kinetics of ET extraction. Statistical analysis demonstrated that the molecular weight of ETs did not influence the kinetics of their extraction, either. It was shown that the technological type of pomace had a significant impact on the extraction rate of both low molecular weight (LMW) and high molecular weight (HMW) ETs in the first extraction step, with the mean t1/2 being 44 min for pomace from juice production and 63 min for pomace from puree production.
Robustness of factor solutions in exploratory factor analysis
Authors: Goretzko David , Bühner Markus
Published: September 2021

Replicability has become a highly discussed topic in psychological research. The debates focus mainly on significance testing and confirmatory analyses, whereas exploratory analyses such as exploratory factor analysis are more or less ignored, although hardly any analysis has a comparable impact on entire research areas. Determining the correct number of factors for this analysis is probably the most crucial, yet ambiguous decision—especially since factor structures have often been not replicable. Hence, an approach based on bootstrapping the factor retention process is proposed to evaluate the robustness of factor retention criteria against sampling error and to predict whether a particular factor solution may be replicable. We used three samples of the “Big Five Structure Inventory” and four samples of the “10 Item Big Five Inventory” to illustrate the relationship between stable factor solutions across bootstrap samples and their replicability. In addition, we compared four factor retention criteria and an information criterion in terms of their stability on the one hand and their replicability on the other. Based on this study, we want to encourage researchers to make use of bootstrapping to assess the stability of the factor retention criteria they use and to compare these criteria with regard to this stability as a proxy for possible replicability.
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil
Authors: Andrade Nathália L. , da Cruz Campos Ana Carolina , Cabral Andrea Maria , Damasco Paula Hesselberg , Lo-Ten-Foe Jerome , Rosa Ana Cláudia P. , Damasco Paulo V.
Published: September 2021

The etiological agent for infective endocarditis (IE), a life-threatening disease, is usually gram-positive bacteria. However, gram-negative bacteria can rarely cause IE and 4% of cases are associated with morbidity and mortality. This study aimed to characterize Escherichia coli and Klebsiella pneumoniae isolates from the blood of patients with IE. The characteristics of blood isolates were compared with those of urinary isolates from patients with urinary tract infections (UTIs). The results of this study revealed that K. pneumoniae isolates from patients with IE were phylogenetically related to those from patients with UTI. Additionally, the resistance phenotype, resistance gene, virulence gene, and plasmid profiles were similar between the blood and urinary isolates. The isolates belonging to the sequence types (STs) 76, 36, 101 (K. pneumoniae), and 69 (E. coli) are reported to be associated with drug resistance. The Enterobacteriaceae isolates from patients with IE did not produce extended-spectrum β-lactamase or carbapenemase. Additionally, this study investigated the virulence phenotype, biofilm formation ability, and the ability to adhere to the epithelial cells in vitro of the isolates. The isolates from patients with IE exhibited weaker biofilm formation ability than the urinary isolates. All isolates from patients with IE could adhere to the renal epithelial cells. However, three isolates from patients with UTIs could not adhere to the epithelial cells. The closely related K. pneumoniae isolates (648, KP1, KP2, KP3, and KP4) could not form biofilms or adhere to the epithelial cells. In summary, the molecular analysis revealed that the genetic characteristics of IE-causing K. pneumoniae and E. coli were similar to those of UTI-causing isolates. These isolates belonged to the STs that are considered treatable. Genetically similar isolates did not exhibit the same virulence phenotype. Thus, these non-hypervirulent clones must be monitored as they can cause complex infections in susceptible hosts.
COVID-19 and output in Japan
Authors: Fujii Daisuke , Nakata Taisuke
Published: September 2021

We build a tractable SIR-macro-model with time-varying parameters and use it to explore various policy questions such as when to lift the state of emergency (SOE). An earlier departure from the SOE results in smaller output loss and more deaths in the short run. However, if the SOE is lifted too early, the number of new cases will surge and another SOE may need to be issued in the future, possibly resulting in both larger output loss and more deaths. That is, the tradeoff between output and infection that exists in the short run does not necessarily exist in the long run. Our model-based analysis—updated weekly since January 2021, frequently reported by media, and presented to policymakers on many occasions—has played a unique role in the policy response to the COVID-19 crisis in Japan.
Human-Factor Risk Mitigation in Outdoor Climbing Areas: Survey of Existing Policies in Regulated Climbing Areas
Authors: Meltzer Jourdan H. , Forrester Joseph D.
Published: September 2021

Introduction

Popular climbing areas in the United States are frequently on public lands under administrative purview of land management entities. During climbing, climbers may be subject to injury. This study aimed to describe existing climbing risk mitigation tactics used to protect climbers by oversight agencies responsible for these public climbing areas and to identify strategies perceived by the oversight agency to be successful.

Methods

We identified publicly managed US bouldering, sport, or traditional climbing areas through a state-by-state search of Mountain Project. We assessed climbing-related visitation, injury, rescue, and risk mitigation strategies using a 10-item survey targeting land-use managers, rangers, outdoor recreation planners, and park managers. Quantitative analysis included univariate and multivariate analysis. Qualitative analyses of survey responses with thematic grouping of mitigation interventions were performed.

Results

One hundred fifty-seven publicly managed US climbing areas were contacted, and 76 (48%) provided data. Thirty-six (47%) of those that provided data stated that programs are in place to reduce climbing-related injury. There were no associations between demographic variables and the presence of risk mitigation strategies. Four themes of climbing risk mitigation strategies emerged: coordination with climbing coalitions (25% of respondents), permitting (22% of respondents), publication of accident reports (22% of respondents), and preventative search and rescue (17% of respondents).

Conclusions

Nearly half of survey respondents reported having climbing risk mitigation programs. There is opportunity to assess the efficacy of risk mitigation strategies through intra-area and inter-area assessments. A centralized climbing injury database may prove useful for assessing the efficacy of and need for risk mitigation techniques.
The Disease Ecology, Epidemiology, Clinical Manifestations, Management, Prevention, and Control of Increasing Human Infections with Animal Orthopoxviruses
Authors: Diaz James H.
Published: September 2021

Zoonotic orthopoxvirus outbreaks have occurred repeatedly worldwide, including monkeypox in Africa and the United States, cowpox in Europe, camelpox in the Middle East and India, buffalopox in India, vaccinia in South America, and novel emerging orthopoxvirus infections in the United States, Europe, Asia, and South America. Waning smallpox immunity may increase the potential for animal-to-human transmission followed by further community transmission person-to-person (as demonstrated by monkeypox and buffalopox outbreaks) and by contact with fomites (as demonstrated by camelpox, cowpox, and, possibly, Alaskapox). The objectives of this review are to describe the disease ecology, epidemiology, clinical manifestations, prevention, and control of human infections with animal orthopoxviruses and to discuss the association with diminished population herd immunity formerly induced by vaccinia vaccination against smallpox. Internet search engines were queried with key words, and case reports, case series, seroprevalence studies, and epidemiologic investigations were found for review.
Interstellar and Intergalactic Medium
Authors: Ryden Barbara , Pogge Richard W.
Published: September 2021

This concise textbook, the first volume in the Ohio State Astrophysics Series, covers all aspects of the interstellar and intergalactic medium for graduate students and advanced undergraduates. This series aims to impart the essential knowledge on a topic that every astrophysics graduate student should know, without going into encyclopedic depth. This text includes a full discussion of the circumgalactic medium, which bridges the space between the interstellar and intergalactic gas, and the hot intracluster gas that fills clusters of galaxies. Its breadth of coverage is innovative, as most current textbooks treat the interstellar medium in isolation. The authors emphasise an order-of-magnitude understanding of the physical processes that heat and cool the low-density gas in the universe, as well as the processes of ionization, recombination, and molecule formation. Problems at the end of each chapter are supplemented by online projects, data sets and other resources.
Finding the right candidate: Developing hiring guidelines for screening applicants for clinical research coordinator positions
Authors: Fisher Elaine , Thomas Rebecca S. , Higgins Melinda K. , Williams Charlie J. , Choi Ikseon , McCauley Linda A.
Published: September 2021

Impact:

The success of any clinical research team is dependent on hiring individuals with the experience and skill set needed for a specific research project. Strategies to improve the ability of human resource (HR) recruiters to screen and advance qualified candidates for a project will result in improved initiation and execution of the project.

Objective/Goals:

HR recruiters play a critical role in matching research applicants to the posted job descriptions and presenting a list of top candidates to the PI/hiring manager for interview and hiring consideration.

Methods/Study Population:

Creating guidelines to screen for applicant qualification based on resumes when clinical research positions have multiple levels of expertise required is a complex process of discovery, moving from subjective rationale for rating individual resumes to a more structured less biased evaluation process. To improve the hiring process of the research workforce, we successfully developed guidelines for categorizing research coordinator applications by level from beginner to advanced.

Results/Anticipated Results:

Through guideline development, we provide a framework to reduce bias and improve the matching of applicant resumes to job levels for improved selection of top candidates to advance for interviewing. Improved applicant to job matching offers an advantage to reduce hiring time, anticipate training needs, and shorten the timeline to active project engagement. These guidelines can form the basis for initial screening and ultimately matching individual qualities to project-specific needs.
IAMBLICHUSAPVDSIMPL.COROLLARIVM DE TEMPORE794.21–7 DIELS
Authors: Johns Jeffrey M.
Published: September 2021

In his commentary on theTimaeus, the Neoplatonist Iamblichus argues that time is logically antecedent to change inasmuch as time is no mere aspect of change. Naturally, scholars appraise this thesis in light of Neoplatonic metaphysics. Nevertheless, they neglect the philological framing of this thesis, and thence the philosophical implications thereof. Only J.M. Dillon acknowledges this framing, though even Dillon does not acknowledge the philosophical implications thereof. This article illustrates the logic of said thesis vis-à-vis the Iamblichean exegesis ofTi. 38b7–c1 (Iambl.apudSimpl.in Phys.1.794.21–7 Diels, Iambl.in Ti. fr. 67 Dillon). Beginning from the intuition that time is no mere aspect of change, Iamblichus argues that time can persist apart from change, and thereupon, given the Platonic notion that time is the everlasting image of Eternityquaparadigm, Iamblichus intuits that time is no mere image but everlasting in its own right, being itself a paradigm. Yet this thesis rests upon the indeterminateness of the Platonic titleτὸ παράδειγμα τῆς διαιωνίας φύσεως(‘the paradigm of a thoroughly everlasting nature’) atTi. 38b8 and, still more so, upon the reflexiveness of the ambiguousΑΥΤΩΙ(that is,αὐτῷ‘toit[the paradigm]’, if notαὑτῷ‘toitself[as paradigm]’) atTi. 38c1. Inasmuch as the subject of the Platonic title is indeterminate between Eternity and Eternal Beingquaintelligible everlastingness, Iamblichus construesΑΥΤΩΙnot as a mere reflexive but as self-reflexive, withαὑτῷreferring to Timequaintelligible paradigm. In this light, the Platonic lemma grounds the Iamblichean thesis.
Nonlinear reversed shear Alfvén eigenmode saturation due to spontaneous zonal current generation
Authors: Wei Shizhao , Wang Tao , Chen Ningfei , Qiu Zhiyong
Published: September 2021

General nonlinear equations describing reversed shear Alfvén eigenmode (RSAE) self-modulation via zero-frequency zonal structure (ZFZS) generation are derived using nonlinear gyrokinetic theory, which are then applied to study the spontaneous ZFZS excitation as well as RSAE nonlinear saturation. It is found that both electrostatic zonal flow and electromagnetic zonal current can be preferentially excited by finite-amplitude RSAE, depending on specific plasma parameters. The modification to local shear Alfvén wave continuum is evaluated using the derived saturation level of zonal current, which is shown to play a comparable role in saturating RSAE with the ZFZS scattering.
Food promotions and the cost of a healthy diet
Authors: Furey Sinéad
Published: September 2021

With approximately two in three UK adults overweight or obese, one in five living in poverty and our emergence from the Covid-19 pandemic with implications for employment and income status there is an urgent need to understand what it costs to eat healthily and the role that promotions can play in helping householders manage food budgets. The literature suggests that, in affluent countries, price promotions appear to increase consumer food purchases and are applied more frequently to less healthy products than their healthy counterparts. This review discusses the cost of a healthy diet, identifies the prevalence of promotions in both the supermarket setting generally and a typical shopping basket specifically, and discusses the barriers to affording a healthy diet. Given the current policy focus on the cost of living and population health emphasising the need for food shopping to represent health and value for money for better public health outcomes, this review contributes to the evidence base for retailers' and policymakers' consideration as policy solutions are sought to reduce population obesity levels, while ensuring the affordability and accessibility of nutritious food. It is important, given the shift in consumer purchasing behaviour to online shopping as a result of self-isolating or reticence to physically access stores in response to the Covid-19 pandemic, that retail food promotions are available irrespective of the chosen mode of shopping (in-store or online).
Identifying the characteristics of conservation areas that appeal to potential flagship campaign donors
Authors: Dobson Fiona , Fraser Iain , Smith Robert J.
Published: September 2021

The conservation flagship approach is a valuable tool for raising funds and awareness, but species-based campaigns have been criticized for providing little benefit to wider biodiversity. One possible solution is to use conservation areas as flagships, but we lack data on the types of area that most appeal to potential donors. Here, we used an online choice experiment involving hypothetical overseas conservation areas to investigate how respondents value a series of conservation area attributes. We calculated the average willingness to pay for each attribute and assessed preference heterogeneity. Our results suggest that community ownership is valued the most, followed by the presence of threatened bird species, low current funding in the conservation area, the presence of charismatic mammals, and charity ownership. Respondents could be divided into three groups, based on their education, environmental organization membership and income. The group of respondents who were less wealthy and were members of environmental organizations were not willing to pay for this kind of conservation action, suggesting that flagship area campaigns targeted at them should encourage other types of involvement. The other two groups, which included respondents who were less engaged in conservation (neither group included environmental organization members, with one group less wealthy and less educated, and the other wealthier), found community ownership particularly appealing, suggesting that many potential donors may be driven by social concerns. This is a key finding and suggests flagship conservation areas could attract a new audience of donors, helping to support current global efforts to increase the management effectiveness, connectivity and extent of protected areas and land under other effective area-based conservation measures.