bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and characterization of alginate microparticles for oral delivery of Alpha-tocopherol
Authors: Živković Milja , Barjaktarević Ana , Tomović Marina , Uštević Anđela
Published: November 2024

Introduction/Aim. Microencapsulation technology can be used for the protection of Alpha-tocopherol from degradation in unfavorable environments and enhancement of bioavailability and shelf-life of vitamin E. The aim of this study was the synthesis and characterization of alginate microparticles for the oral delivery of a-tocopherol. Methods. Four different formulations of Alpha-tocopherol loaded calcium alginate microparticles for oral delivery were synthesized by external ionotropic gelation method. The vitamin E content in microparticles was 0.5%, 1% and 2% (w/w); the vitamin E/sodium alginate ratio was 1:1 and 1:2. All microparticles were characterized by average particles size, swelling degree, vitamin E content, loading capacity, and encapsulation efficiency. Results. Spherically shaped microparticles with the diameter of 500 to 1000 µm were obtained after the drying process. The size and the swelling degree did not change significantly in 0.1 M HCL, while they were increased in base conditions of phosphate buffer of pH 6.8 and 7.4. Encapsulated vitamin E content was not significantly different between formulations (0.30 ± 0.010 - 0.60 ± 0.021 mg/mL). The loading capacities were in the range between 10 ± 0.11% and 20.45 ± 0.22%, while encapsulation efficiency percentages were between 18.94 ± 0.32% and 31.91 ± 0.41%. Conclusion. The optimum conditions for Alpha-tocopherol encapsulation with the highest percentage of loading capacity and encapsulation efficacy were obtained using 1% sodium alginate, 2% calcium chloride, and vitamin E/polymer in the ratio 1:1. All four formulations showed the expected behavior in different mediums, which simulated gastrointestinal fluids in vivo (0.1 M HCL, phosphate buffer pH 6.8 and pH 7.4): gastroresistance, increasing in the size, and swelling degree in intestinal fluids. This emphasizes the use of alginate microparticles as a carrier for the oral delivery of vitamin E.
Comparative characteristics of plum seed oil obtained by supercritical and Soxhlet extraction
Authors: Kazanović Radmila , Maksimović Svetolik , Stanković Milica , Ibišević Merima , Tadić Vanja , Nešić Ivana
Published: November 2024

Introduction/Aim. Plums, as one of the oldest types of fruits, are very important in the human diet. The most common varieties of plums cultivated in the territory of Bosnia and Herzegovina are Požegača, Čačanska lepotica, Čačanska rodna and Valjevka. They belong to the group of basic fruits rich in various vitamins and minerals. In addition, plum seed oil is used in the cosmetic industry. This oil is a rich source of biologically active components with proven biological effects - it hydrates the skin and improves its elasticity; the skin easily absorbs it without leaving a greasy film on the surface. The aim of this study was to find the optimal method for isolating fatty oil from the seeds of four types of plums with the best characteristics. Their potential as raw material in the cosmetic industry through the application of supercritical and Soxhlet extraction and their characterization was examined. Methods. Fatty oils were extracted by conventional Soxhlet extraction with non-polar organic solvent and by supercritical extraction with carbon dioxide. The AOAC 930.15 method was used to determine the moisture content of the plum seeds. The oils were characterized by determining the organoleptic characteristics, as well as the acid, iodine, saponification and peroxide number. Results. The fattiest oil was obtained from the pits of the Čačanka rodna plum using the both extraction methods, supercritical and Soxhlet extraction. Fatty oil of Požegača had the lowest values of iodine and peroxide number, while the acid and saponification number were the lowest within the oil from Valjevka and Čačanka rodna, respectively. Conclusion. Both extraction methods showed good extraction yields, with higher extraction capacity using Soxhlet extraction. Čačanka rodna had the highest amount of oil. Fatty oils from all varietes showed excellent characteristics, so the plum kernels can be potentially used for obtaining fatty oil for cosmetic purposes due to its beneficial effect on the skin.
The relationship between sleep disorders, level of psychological stress and state-trait anxiety in patients with anxiety disorders
Authors: Zhyvotovska Anastasiia , Boiko Dmytro , Bodnar Lesya , Kozar Yurii , Martynenko Yanina , Isakov Rustam
Published: November 2024

Introduction/Aim. There is a cause-and-effect relationship between stress, sleep disorders and emotional brain function. Insufficient quality and duration of sleep can trigger or exacerbate anxiety in an individual. The study aims to assess the scores for sleep disorders and the level of stress depending on typological features of state and trait anxiety in patients with anxiety disorders and sleep disturbances, as well as to establish the relationships between them. Methods. Ninety-one patients with anxiety disorders and sleep disturbances, aged between 21 and 59 years, were examined. The following methods were used to access the levels of psychological stress, state/trait anxiety and sleep disorders: the Integrative Anxiety Test, PSM-25 questionnaire, PSQI, ISI and ESS. Results. The highest number of correlations between the state anxiety components and the level of stress (p < 0.01), severity of insomnia, global score, sleep latency and duration measured by the PSQI was established (p < 0.05). As for the trait anxiety, it correlated significantly with the level of stress (p < 0.01), PSQI global score, sleep duration, sleep efficiency, and sleep latency (p < 0.05). Conclusion. A significant correlation was established between the state/trait anxiety and the level of stress, as well as the scores on the PSQI, ISI, ESS scales within the cohort of patients with anxiety disorders. The study on the relationship between the scores of the level of stress, sleep disorders, and state/trait anxiety emphasizes the importance of considering the findings in the implementation of comprehensive personalized therapy and psychotherapy for the abovementioned cohort of patients.
The role of interleukin-8 in the development and clinical progression of chronic periapical lesions
Authors: Popović Jelena , Cvetković Tatjana , Džopalić Tanja , Mitić Aleksandar , Nikolić Marija , Barac Radomir , Stošić Nenad , Stanković Antonije
Published: November 2024

Introduction/Aim. Chronic apical periodontitis represents dynamic continuation of the presence of endodontic infection in the root canal system of the tooth, when the innate and acquired immune responses are activated and various cells and inflammatory mediators are recruited, which cause the consequent destruction of periapical tissues and the development of periapical lesions. The aim of the study was to analyze the concentration of IL-8 in tissue homogenates of periapical lesions and to compare the obtained results with the symptomatology of the patients and the size of the lesion. Methods. A total of 93 tissue samples of chronic periapical lesions were analyzed in this study. In relation to the clinical symptoms, the samples were divided into symptomatic and asymptomatic, and according to the size, into large and small lesions. The concentration of IL-8 was examined using an ELISA test. Results. The results showed a significantly higher concentration of IL-8 in symptomatic periapical lesions compared to asymptomatic ones (p < 0.001). The concentrations of this chemokine was also significantly higher in the large lesions when compared to the small ones (p < 0.001). Conclusion. The elevated concentration of IL-8 in periapical lesions with pronounced clinical symptomatology as well as in large lesions specify that IL-8 is a dominant chemokine that contributes to the development of periapical inflammation and clinical progression of periapical lesions.
Comparative analysis of potential drug-drug interactions at the level of public pharmacy
Authors: Stanković Sanja , Stefanović Nikola , Jović Maša , Veličković-Radovanović Radmila
Published: November 2024

Introduction/Aim. Understanding the mechanisms and classification of drug interactions can significantly reduce the occurrence of adverse effects and improve compliance. The drug selection process is complex and involves the patient's individual condition, physiological status, use of other drugs, and co-existing illnesses. It is particularly challenging to choose adequate therapy for elderly individuals due to physiological changes and polypharmacy. The aim of this paper is to highlight the importance of an individualized approach to each patient when interpreting information provided by the existing drug databases. This approach involves considering the patient's age, comorbidities, and a proper assessment of the risk-benefit ratio. Methods. A comparative analysis of potential drug-drug interactions was conducted on a sample of 215 outpatients. The analysis was performed using Lexicomp®, Medscape® and Epocrates® databases. The frequency of certain types of interactions by drug databases, the number of patients, and the distribution of interaction types by databases were determined. The frequency of drug combinations that could potentially cause serious and contraindicated interactions by databases were also determined. Results. Based on the study, it can be concluded that there is a correlation between the number of prescribed drugs and potential interactions. According to frequency, the most common type of interaction requires therapy monitoring (type C interaction, Monitor). However, based on the severity categorization, the same drug combinations have different classifications of interactions in available databases. Conclusion. The obtained data can provide guidance in making decisions about drug therapy choices. Patient-specific characteristics, including comorbidities, require a personalized therapeutic approach from specialists, where pharmacists play a significant role.
The impact of selected socio-economic factors on defense expenditures in Southeastern European countries
Authors: Šare Dalibor
Published: November 2024

This research explores the influence of certain socioeconomic factors on defense expenditures in Southeastern European countries. The research was conducted for the period from 2005 to 2021. The aim of the research is to examine the impact of political stability, budgetary allocations for education, and revenues from taxes on goods and services, as independent variables, on defense expenditures as a dependent variable using the STATA software package. By applying the chosen model, the extent to which variations in defense expenditures can be explained by the independent variables used in the model was determined. The conclusion of the research is that the variables used in the model have a significant impact on defense expenditures and provide insight into the complex interactions between social and economic factors and defense expenditures in Southeastern European countries.
Impact of whey bioactive hydrolysates on the quality of fat fillings for confectionery products
Authors: Stožinić Milica , Zarić Danica , Rakin Marica , Lončarević Ivana , Pajin Biljana , Bulatović Maja
Published: November 2024

Whey protein hydrolysates can be used in a wide range of applications because they offer numerous advantages compared to non-hydrolysed whey proteins. They are more heat stable, with improved foaming and emulsifying properties due to the presence of bioactive peptides of lower viscosity. Whey hydrolysates have improved absorption, digestibility, excellent nutritional and functional properties, and the ability to extend the shelf life of food products. Due to the large differences in the technological and other physicochemical properties of hydrolysates, the addition of whey protein hydrolysates into confectionery products is much more complicated. This research aims to determine the possibilities of enriching filled confectionery products with whey peptides obtained in two ways: through enzymatic hydrolysis of whey protein concentrate and fermentation (using microorganism Lb. rhamnosus ATCC 7469). Peptides were added to a fatty milk cream at a 5% concentration. The study was focused on assessing antioxidant activity, physical, rheological, textural, and sensory properties of three fat fillings: C (control without whey peptides), EWP (5% peptides from enzymatic hydrolysis), and MWP (5% peptides from whey fermentation). The Enzymatic hydrolysates increased DPPH radical inhibition by 32%, and fermented hydrolysates by 19%. Enzymatic hydrolysates also demonstrated superior inhibition of lipid peroxidation (IC50 value of 811.54 mg mL-1) compared to fermented hydrolysates (IC50 value of 178.36 mg mL-1). EWP showed the highest antioxidant activity. The addition of enzymatic hydrolysates increased filling firmness by 2.5 times, while fermented hydrolysates had reduced firmness compared to the control. Both types of hydrolysates did not adversely affect the size or distribution of the particles in the fat cream. Thixotropic properties of the fat filling remained unchanged post-incorporation. MWP exhibited the most optimal rheological characteristics with the lowest yield stress. The best sensory characteristics (better than the control sample) were found in the EWP.
The Impact of rhetoric on Jerome Frank's "Digestive jurisprudence"
Authors: Avramović Dragutin , Jovanov Ilija
Published: November 2024

The paper analyses the relationship between law and rhetoric and their intersection areas, particularly focusing on the significance of rhetoric in contemporary judicial proceedings. In the 20th century, the issue of the relationship between law and rhetoric (explicitly or implicitly) became relevant particularly through the scientific excellence of the school of American legal realism , but more recently, it has been somewhat neglected. The authors of this paper devote particular attention to the judicial decision-making theory of Jerome Frank, a prominent legal realist. It is for his radical positions, as a fact sceptic, that he seems to have unconsciously, subtly but persistently, woven into his works the idea of the importance of rhetoric in judicial decision-making processes. The authors explore the reasons behind Frank's hesitation for most of his scientific career to give rhetoric (particularly that of Aristotle, which he quoted most) its deserved place. It was only in one of his later works that Frank attempted to build a bridge between his judicial decision-making theory (insisting on the importance of prejudices and subjectivities of a judge to the judicial decision) and rhetoric (aimed at persuading the judge, evoking his emotions, and creating the image of a particular reality in his eyes). It seems that his effort was only a partial success because, even then, he primarily focused on the methods of touching the "souls of the audience", overlooking the importance of the rhetorical means (primarily logical) that did not lend support for his theory.
Modus operandi of a serial sex offender
Authors: Spytska Liana
Published: November 2024

Background. The relevance of preventing and solving such crimes is growing, and a special place in this is occupied by forensic research, in particular, the analysis of modus operandi of criminals. The purpose of the study was to investigate the modus operandi of serial sex offenders. Methods. The main method of research was criminal profiling based on 50 cases in the Unified State Register of Court Decisions, for which the verdict was passed. Results. A number of indicators were investigated, including the characteristic method of attack, the choice of the victim, how the contact with the victim was established, and the method of committing the offence. As a result, it was established that criminals can be divided into two characteristic types according to modus operandi: the first type carries out a sudden attack or pursuit of the victim, is characterised by a violent method of attack, and the crime is often accompanied by bodily harm. The psycho-emotional portrait of attackers of this type is characterised by greater impulsivity and spontaneity of actions. The main motivation for committing a crime is to satisfy a sexual urge. Criminals of the second cluster tend to commit planned attacks, mostly indoors, establish contact with the victim, resort to manipulation and threats. They have a less pronounced passion and tend to plan crimes. The dominant motivation can be either sexual or the satisfaction of sadistic tendencies and dominance. Conclusions. This study focuses on the characteristic modus operandi and psychological characteristics of criminals who commit serial sexual offences.
Ensemble Stacking of Machine Learning Approach for Predicting Corrosion Inhibitor Performance of Pyridazine Compounds
Authors: Ariyanto Noval , Azies Harun Al , Akrom Muhamad
Published: November 2024

Corrosion is a major challenge affecting various industrial sectors, leading to increased operational costs and decreased equipment efficiency. The use of organic corrosion inhibitors is one of the promising solutions. This study applies an ensemble algorithm with a stacking method to estimate pyridazine-derived compounds corrosion inhibition efficiency. This study utilized various molecular characteristics of pyridazine compounds as inputs to predict inhibition efficiency values. After evaluating several boosting models, the stacking technique was chosen as it showed the best results. Stacking Model 6, which combines XGB, LGBM, and CatBoost as the base model with Random Forest as the meta-model, produced the most accurate prediction with an RMSE of 0.055. These findings indicate that machine learning approaches can effectively and efficiently predict corrosion inhibitor performance. This method offers a faster and more economical alternative to conventional experimental methods.
THE POLICY MODEL FOR SUSTAINABLE COMMUNITY FOREST: A FACTOR ANALYSIS
Authors: Sukwika Tatan , Fransisca Lidya
Published: November 2024

Developing and maintaining forest sustainably is a way to support sustainable development. From the technical point of view, the sustainability of community forest could be articulated not only based on the three aspects i.e. economic (ECO), social culture (SOC), ecology (EGY), but it could also include dimensions of legal and institutional (LIT), as well as accessibility and technology (ACT). This study aims to determine variables of sustainability dimensions that have a direct positive effect on the sustainability of the community forests (SCF), to identify variables that affect SCF and variables of sustainability dimensions that have a major effect on SCF. This study is aiming for 70 samples of forest farmers’ group in Bogor Regency. The respondents were purposively selected based on consideration of the criteria for forest farmer groups namely beginner, intermediate, and advanced. The analysis was conducted based on PSL-SEM tools. Sustainability dimensions of ECO, EGY, LIT, and ACT have a significant positive direct effect on SCF. The mediational hypothesis testing suggested that there is a partial mediation from ECO and EGY to SCF, which is consistent and have a positive value. Based on the coefficient value of the total-effect, among the five dimensions, ecology value was the biggest and the most effect. The policy implies that the ecological aspects considered the importance and strategy. Therefore, the value and productivity of the community forest structure and composition need to be maintained.
BAHASA PERSUASIF PADA TEKS KATOBBA PALLAPPASSANG ‘KHOTBAH LEBARAN’ DI KABUPATEN GOWA
Authors: Saputra Muh Ali , Daeng Kembong , Yunus Andi Fatimah
Published: November 2024

This research aims to describe the form of persuasive language in the text of katobba pallappassang 'Eid sermon' in Gowa Regency, and revealing persuasive techniques in the text of the katobba pallapassang 'Eid sermon' in Gowa Regency. The method was designed using descriptive qualitative research. The data in this study comes from 2 texts of katobba pallappassang 'Eid sermon', 1 text katobba pallappassang rumallang 'Eid al-Fitr sermon', and 1 text of the katobba pallappassang hajj 'Eid al-Adha sermon' obtained from a religious figure named Muh. Ramli, S.Pd.I., Dg. Laja. Data collection was carried out using copy, read and note techniques. The results of the research show that, (1) 4 applications of persuasive form were found, namely persuasive form of invitation, persuasive form of affirmation, persuasive form of advice, and persuasive form of prohibition. (2) 4 applications of persuasive techniques were found, namely association persuasive techniques, integration persuasive techniques, pay off & fear arousing persuasive techniques, and icing persuasive techniques. The application of persuasive forms and techniques is carried out to influence the communicant or congregation so that the desired persuasion goals can be achieved.
Makna Simbolik Appabbajikang Bunting Pada Prosesi Pernikahan Adat Makassar di Desa Pattallikang Kabupaten Gowa
Authors: Putri R Dewi Kania , Hajrah  , Asia M
Published: November 2024

This research is entitled The Symbolic Meaning of Appabbajikang bunting in the Makassar Traditional Wedding Procession in Pattallikang Village, Gowa Regency. This research aims to describe the icons, indices and symbols contained in the process of implementing appabbajikang bunting in Pattallikang village, Gowa Regency in terms of Charles Sanders Peirce's semiotic theory. This type of research is qualitative with a qualitative descriptive research design. The methods used in collecting data for this research were observation, interviews and documentation. The results of this research show that in the process of implementing the appabbajikang bunting tradition in Pattallikang village, Gowa Regency it has the meaning of (1) icons, namely tai bani and doek. (2) the meaning of the index, namely dupa, nipaasori lipak, and nisioi na sisioi kanrejawa. (3) the meaning of the symbols, namely jajjakkang, umba-umba, tai bani, doek, kanrejawa lapisik, lawarak kadea, kanrejawa sirikaya, songkolok palopok, jeknek inung, lekok kalomping, lipak. In general, the meaning contained in the tradition of the appabbajikang bunting procession in Pattallikang village, Gowa Regency is to unite the bride and groom, obtain abundant fortune, and have a prosperous household life.
Strategies For Managing Disruptive Behaviours Among Public Secondary Schools’ Students in Classrooms in Kogi East Education Zone Nigeria
Authors: Leonard Shaibu , Haruna Mohammed Sani , Inikpi Ogwu Hannah , Ojochenemi Ukpoju Bartholemew
Published: November 2024

The study investigated strategies for managing disruptive behaviours among public secondary school students in classrooms in Kogi East Education Zone. The purpose of the study was to find out the causative factors responsible for students’ classroom disruptive behaviours and strategies to be adopted by public secondary school teachers in the management of students’ classroom disruptive behaviours. Two research questions guided the study. A descriptive survey design was adopted. The population of the study consisted of 2434 teaching staff from 208 secondary schools in the Kogi East education zone. A sample of 400 teachers representing 16% was purposively selected for the study. The Disruptive Behaviour Management Questionnaire (DBMQ) was used as an instrument for data collection. Mean and standard deviation was used to answer the research questions that guided the study with a benchmark of 2.50 for acceptance and rejection. It was revealed from the analysis that (1) hereditary factors, visual disability, mental disability, excessive intelligent quotient in an individual student, exposure of students to the use of computers, television, radios, internet, mobile phones and frustration resulting from emotional to be the causative factors responsible for students’ classroom disruptive behaviours in Kogi East Education Zone. (2) Finding the cause, inducing the desirable behaviour, eliminating the undesired behaviour, systematic desensitization, ignoring strategy, dealing directly with persistent behaviours and monitoring techniques to be strategies for managing students’ disruptive behaviours in the classroom in Kogi East Education Zone. Some recommendations were also made.
Tax collection efficiency and tax revenue generation in Nigeria
Authors: Audu Ibrahim Solomon , Akinrinola Olalekan , Somorin Teju
Published: November 2024

When compared to other African countries, Nigeria has one of the lowest tax to GDP ratios among the top ten largest countries in Africa. Hence, this study assessed the effect of tax collection efficiency on the level of tax revenue in Nigeria. The study is built theoretically on the cost-benefit theory of taxation. Secondary data was collected in this study over an eleven-year time period which range over 2011 to 2021. The data were processed analytically using the regression model to measure the effect of the independent variable which is tax cost of collection efficiency on the dependent variables which are direct cost and indirect taxes and moderated by accountability of the collecting agency. The outcome of the study shows the regression result of 74.3% and a calculated p-value of 0.002 which shows that tax collection cost efficiency have a high level of significance effect on direct tax revenue generation in Nigeria. It is concluded from the result that tax collection cost efficiency does have a significant effect on tax revenue generation in Nigeria. Based on the outcome of the study, it is advised that more prudent measures be set up so as to ensure improvement in the tax collection process in order to manage tax collection cost efficiently and improve tax revenue generation in Nigeria.
Influence of Students Attitude on the Management of Discipline in Public Secondary Schools
Authors: Ndungu Anne Wanjiku
Published: November 2024

School discipline is a matter of concern particularly among teachers, family, educators and other stakeholders. Students cannot learn and teachers cannot teach effectively in an undisciplined and unsafe environment and therefore order and discipline are necessary for successful educational outcomes. The purpose of this study was to assess the influence of students attitude on the management of discipline in public secondary schools in Kigumo Sub County, Muranga County. The study was guided by the Social Learning Theory and System Management Theories. The study adopted a concurrent triangulation design with a mixed design methodology where both qualitative and quantitative methods were employed. The study population were all the public secondary schools in Kigumo Sub County, Muranga County including all the students, teachers and deputy principals. A stratified random sampling method was used to pick 379 students. Purposive sampling was used to pick 30 deputy principals and 30 teachers in charge of discipline management. Questionnaires and interview schedules were used in data collection. The study was piloted in 5 schools in the neighbouring Kahuro Sub County. Reliability and validity of the research instruments were tested during piloting as well as taking into consideration 2 experts’ assessments respectively. Statistical Package for Social Sciences (SPSS) was used in data analysis to generate the frequencies, descriptive statistics, cross-tabulation statistics, chi-square tests as well as correlation coefficient statistics that were used to analyze the data and answer the research questions. Findings were presented using statistical tables. The study made some important findings that drew it to make some important conclusions. It can be noted that there were significant relationships between school characteristics and issues of indiscipline. In the recommendation, guidance and counselling should be included as part of the secondary school curriculum. Additionally, community centres and rehabilitation centres should setup to take care of students and promotion social activities.
Strategy for Improving Business Performance in Micro and Small Enterprises through Innovation and Digitalization
Authors: Gunawan Achmad Wijaya , Winarto Santoso Henrycus
Published: November 2024

This study aims to examine strategies for enhancing business performance in micro and small enterprises (MSEs) through the integration of innovation and digitalization. In an era where digital transformation has become critical for competitiveness, MSEs face unique challenges due to limited resources, constrained access to technology, and often limited technical expertise. Using a qualitative approach through library research and literature review, this study synthesizes current research on the role of innovation and digital adoption in boosting productivity, expanding market reach, and improving operational efficiencies in MSEs. Findings reveal that innovation and digitalization not only facilitate access to broader customer bases but also enable cost-effective marketing and streamlined operations. Additionally, the analysis indicates that overcoming barriers such as technology adoption costs and skill gaps is essential for successful digital transformation in MSEs. Supportive policies, digital literacy training, and partnerships with technology providers emerge as critical components to foster a conducive environment for these enterprises. The study contributes to the ongoing discourse by identifying key success factors for MSEs embarking on digital and innovative transformations. Furthermore, it provides recommendations for policy makers, business owners, and stakeholders to enhance MSE resilience and competitiveness in a digitalized economy. This research underscores the importance of aligning digital strategies with business goals to ensure sustainable growth and adaptation in a rapidly evolving market landscape.
Chronic Neutrophilic Leukemia Developing in a Patient with Myelodysplastic Syndrome: A Case Report and Review of the Literature
Authors:   Department 8: Radiology, Oncology and Hematology, Carol Davila University of Medicine and Pharmacy, Hematology Discipline, Colțea Clinical Hospital, Bucharest, Romania, LAPADAT Mihai Emilian , STANCA Oana ,   Department 8: Radiology, Oncology and Hematology, Carol Davila University of Medicine and Pharmacy, Hematology Discipline, Colțea Clinical Hospital, Bucharest, Romania, TRIANTAFYLLIDIS Irina Nicoleta ,   Department 8: Radiology, Oncology and Hematology, Carol Davila University of Medicine and Pharmacy, Hematology Discipline, Colțea Clinical Hospital, Bucharest, Romania, CIOBANU Anca Mariana ,   Hematology Clinic, Colțea Clinical Hospital, Bucharest, Romania, MAMBET Cristina ,   Department 8: Radiology, Oncology and Hematology, Carol Davila University of Medicine and Pharmacy, Hematology Discipline, University Emergency Hospital of Bucharest, Bucharest, Romania, COLITA Andrei ,   Department 8: Radiology, Oncology and Hematology, Carol Davila University of Medicine and Pharmacy, Hematology Discipline, Colțea Clinical Hospital, Bucharest, Romania
Published: November 2024

Chronic neutrophilic leukemia (CNL) is an extremely rare hematological malignancy, characterized by clonal proliferation of mature neutrophils, whose diagnosis has been facilitated in the last decade by the identification of a highly specific CSF3R T618I mutation. Myelodysplastic syndromes (MDS) are a group of hematological malignancies that share a common characteristic: dysplasia of the bone marrow. The association between the two entities is infrequent. A 65-year-old female patient with high-risk MDS developing CNL is described. She had a 2-year history of MDS with excess blasts type II with diagnosis based on dysplasia, presence of CD45-positive blasts in the marrow, thrombocytopenia and cytogenetic abnormalities (21 trisomy). She received azacitidine for eighteen courses, with good response to treatment. Approximately 25 months later, she started developing marked leukocytosis with neutrophilia (WBC 80.25 x 109/l with neutrophils 68.30 x 109/l), thrombocytopenia (49 x 109/l) and splenomegaly (16.5 cm in the long axis). Next Generation Sequencing examination revealed the presence of a CSF3R T618I mutation, alongside an ASXL1 mutation and PTPN11 mutation. Treatment with hydroxyurea was initiated with poor outcome. The patient died one month later of cerebral hemorrhage.
Socio-economic segregation in growing urban regions of Lithuania
Authors: Burneika Donatas , Ubarevičienė Rūta , Valatka Vytautas
Published: November 2024

This study attempts to analyse socio-economic segregation in three metropolitan areas of Lithuania. Indexes of segregation, dissimilarity and isolation were analysed trying to reveal different aspects of socio-spatial segregation in the urban regions, which experienced major shifts in their occupational structure over the last decades. The main occupational groups were used as a proxy for the socio-economic status. Data from 2001 and 2011 censuses was used to investigate segregation processes in the metropolitan areas and their main structural zones – urban cores and suburbs. Notwithstanding major economic and social changes of the post-communist society, all measured indexes indicated low levels of segregation and limited changes during the analysed period. The results showed that the fastest increase of segregation was in the capital city. It was also revealed that the rich­est groups of population are the most segregated, and they tend to live more and more separately from other groups. The differences in the concentration of high and low status occupational groups and the changes in those patterns were illustrated in the maps.
Lietuvos energetinio saugumo politikos poveikis visuomenės socialinei sanglaudai
Authors: Genys Dainius , Krikštolaitis Ričardas
Published: November 2024

Straipsnio tikslas – empiriškai ištirti energetinio saugumo politikos poveikį Lietuvos socialinei sanglaudai. Straipsnis paremtas J. Jenson (1998) ir P. Bernardo (1999) atliktais tyrimais bei pasiūlytomis analitinėmis kategorijomis. Konceptuali schema identifikuoja konkrečias – ekonominę, politinę ir sociokultūrinę – aktyvumo sritis, kurios analizuojamos tikrinant dichotomijas tarp visuomenės požiūrio bei visuomenės elgsenos. Šios dichotomijos leidžia išskirti empirines analizės dimensijas, kurių kiekybinės išraiškos leidžia aprašyti energetinio saugumo politikos poveikį Lietuvos socialinei sanglaudai.
Kaimo tipo gyvenviečių patrauklumas jaunimui poindustrinėje visuomenėje
Authors: Vidickienė Dalia , Melnikienė Rasa , Ribašauskienė Erika
Published: November 2024

Viešosios politikos formuotojai pastaruoju metu vis daugiau dėmesio skiria esminiams skirtumams, išryškėjusiems ekonominei sistemai perėjus į poindustrinį etapą. Su didžiausiais iššūkiais susiduria kaimo politikos programų rengėjai, nes situacija kaimiškuose regionuose keičiasi ypač sparčiai. Straipsnyje pristatomas tyrimas, patvirtinantis jaunų išsilavinusių Lietuvos žmonių, ketinančių įsikurti nuolatiniam gyvenimui kaimo tipo gyvenvietėje ar vienkiemyje, orientaciją į poindustrinę ekonominę ir socialinę visuomenės struktūrą. Kriterijų, lemiančių apsisprendimą įsikurti gyventi kaime, išsiaiškinimas leidžia pateikti rekomendacijas kaimo politikos kūrėjams, siekiantiems pritraukti į kaimiškus regionus tiek gyventojų, kad žmogiškųjų išteklių kiekis ir kokybė sudarytų kritinę masę, reikalingą tolesnei šių regionų ekonominei ir socialinei raidai.
Guidelines for Resolving Psychological Fatigue in Professional Badminton Athletes
Authors: Wang Zhengming , Hongsaenyatham Prakit , Tasnaina Nopporn
Published: November 2024

Background and Aim: Professional badminton players must address psychological exhaustion if they hope to maintain their high level of play and general well-being. Athletes who effectively manage their mental tiredness are more likely to be able to sustain their focus, resiliency, and long-term professional success. This research article aims to develop guidelines for resolving psychological fatigue among professional badminton athletes. The study explores the underlying causes, manifestations, and strategies to manage psychological fatigue, emphasizing the importance of mental resilience and holistic athlete well-being.
Materials and Methods: The sample group consists of eight professional badminton athletes from the Chinese National Badminton Team, with an average age of 22.3 years, including both male and female participants. The selection of these athletes was purposive, focusing on those with at least one year of experience at the professional level and who have encountered psychological fatigue during their careers. The research employed qualitative methods, using semi-structured interviews as the primary tool. These interviews were conducted with both athletes and their coaches to gather in-depth insights into the psychological challenges faced and the coping mechanisms employed. The interview questions for coaches aimed to uncover the causes and management strategies of psychological fatigue, while the questions for athletes focused on their personal experiences and resolving psychological fatigue techniques. Data analysis involved thematic analysis, identifying patterns and themes related to psychological fatigue and self-adjustment strategies. The study used qualitative validation methods, including triangulation, member checking, and peer debriefing, to ensure the reliability and credibility of the findings.
Results: The results indicate that psychological fatigue in professional badminton athletes is influenced by various factors, including injuries, match losses, and the pressure of competing in hostile environments. The study found significant impacts on performance, such as impaired decision-making, reduced concentration, and decreased emotional regulation. Recovery strategies identified include mental resilience training, mindfulness practices, and the support of a robust network of coaches, psychologists, family, and teammates.
Conclusion:  Addressing psychological fatigue requires a comprehensive approach integrating mental health programs with physical training. The study's guidelines advocate for regular mental resilience training, mindfulness practices, and tailored interventions to enhance athletes' mental well-being. By implementing these strategies, athletes can better manage psychological fatigue, improving their overall performance and sustaining their athletic careers.
La farfalla e la candela: ancora sulla preistoria di Amore e Psiche
Authors: Braccini Tommaso
Published: November 2024

Estudios recientes han reevaluado seriamente la posibilidad de que la historia de Cupido y Psique en las Metamorfosis de Apuleyo sea una reelaboración de una narración preexistente (análoga al cuento tipo ATU 425B, Son of the witch), documentada por testimonios iconográficos que a veces parecen ilustrar episodios omitidos por el propio Apuleyo. La investigación sobre los folktales, por el otro lado, ha demostrado la posibilidad de continuidad incluso a largo plazo. Cabe preguntarse si el enigmático “motivo de las velas”, que amenazan al protagonista en numerosas variantes modernas (con especial frecuencia en la zona “paleohelénica” de Grecia, Italia meridional y Turquía) de ATU 425B, no remite precisamente a un episodio en circulación en la Antigüedad, cuando la heroína era identificada con Psique y equiparada, en el nombre y en los testimonios iconográficos, a una mariposa, y como tal peligrosamente atraída por velas y lámparas.

Gli ultimi studi hanno seriamente rivalutato la possibilità che la storia di Amore e Psiche nelle Metamorfosi di Apuleio sia la rielaborazione di una narrazione preesistente (analoga al tipo folklorico ATU 425B, Son of the witch), documentata da attestazioni iconografiche che talora sembrano illustrare episodi tralasciati dallo stesso Apuleio. La ricerca sui folktales, d’altro canto, ha mostrato la possibilità di continuità anche sul lungo periodo. Ci si può dunque chiedere se l’enigmatico “motivo delle candele”, che minacciano la protagonista in numerosissime versioni moderne (con particolare frequenza nell’areale “paleoellenico” di Grecia, Italia Meridionale e Turchia) di ATU 425B, non possa rimandare proprio a un episodio in circolazione nell’antichità, quando l’eroina era identificata con Psiche ed equiparata, nel nome e nelle attestazioni iconografiche, a una farfalla, e come tale pericolosamente attratta da candele e lucerne.
Virgilio lírico: La influencia de los poetas líricos y elegíacos griegos en la Eneida
Authors: Fratantuono Lee
Published: November 2024

Se ha estudiado relativamente poco la influencia de los poetas líricos y elegíacos griegos en la Eneida de Virgilio. El examen detallado de algunos pasajes del corpus de poesía lírica y elegíaca griega arcaica y clásica que se conservan demostrará la omnipresente influencia de estas obras en este poeta de época augustea.

Relatively little work has been done on the influence of the Greek lyric and elegiac poets on Virgil's Aeneid. Close consideration of a number of passages from the surviving corpus of archaic and classical Greek lyric and elegiac poetry will demonstrate the pervasive influence of these works on the Augustan epicist.
La sfida della traduzione in versi. Una nota in margine alla prima versione in lingua inglese dell’Orestis tragoedia di Draconzio
Authors: Tempone Paola
Published: November 2024

El artículo contiene algunas reflexiones sobre la traducción poética al margen de una versión reciente en inglés de Orestis tragoedia de Dracontius de Paul Roche. A partir de algunas consideraciones preliminares acerca de las peculiaridades estilísticas del epilio, se ofrece un análisis de la traducción (métrico, semántico, retórico y sintáctico). El artículo intenta demostrar cómo Roche, que propone una versión sustancialmente fiel del texto original, destinada tanto a un público académico como a uno más amatorial, ha realizado en ocasiones elecciones reader oriented, tratando de tener adecuadamente en cuenta al lector contemporáneo.

L’articolo contiene alcune riflessioni in materia di traduzione poetica in margine a una recente versione in lingua inglese dell’Orestis tragoedia di Draconzio a opera di Paul Roche. Ad alcune sintetiche considerazioni preliminari sulle peculiarità stilistiche dell’epillio draconziano, segue un’analisi della traduzione sotto i profili metrico, semantico, retorico e sintattico. L’articolo vuole dimostrare come Roche, che propone una versione sostanzialmente fedele del testo draconziano, destinata ad un pubblico sia specialistico che amatoriale, abbia talvolta effettuato delle scelte reader oriented, tenendo adeguatamente in conto il lettore contemporaneo.
Optimización de la cadena de suministro para reducir gastos de operación al importar material MRO en la planta de metales en la empresa X
Authors: Gutiérrez Segovia Eduardo Antolín , Anaya Carrasco José Luis , Rodríguez Medina Manuel Arnoldo , Gómez Zepeda Perla Ivette , Pinto Santos Jorge Adolfo
Published: November 2024

La importancia de optimizar la cadena de suministro se debe a la situación actual que enfrenta la compañía X, respecto al tiempo de entrega, mala planeación y poca distinción entre el material más crítico que forma parte del material indirecto, es decir, que no forma parte del costo del producto terminado. Por estas razones, se llevó a cabo esta investigación con la finalidad de aportar sugerencias y alternativas orientadas a un problema estructural, es decir, una problemática cotidiana que genera muchas deficiencias en los inventarios de materia indirecta que repercute en las operaciones, así como los procesos de la planta.
Se pretende realizar una transición de compras tácticas a compras estratégicas por medio de una licitación de consumibles en la planta de metales, donde se presenta con mayor frecuencia la falta de suministros. El artículo en cuestión presenta una revisión de la literatura que da sustento al objeto de investigación, así como de los resultados finales que se obtengan, mismo que tiene como objetivo optimizar la cadena de suministros en un 10% al importar material MRO en la planta de metales de la empresa X.
Para ello, se realizó una búsqueda sistemática de artículos científicos sobre los temas mencionados en diversas bases de datos electrónicas entre los años 2000 al 2021. La revisión permitió identificar 45 artículos, de los cuales solo 36 fueron seleccionados para lo que aquí se presenta. Se concluye por medio de la revisión de literatura, que ciertos autores están de acuerdo en la optimización de la cadena de suministro para poder generar un impacto en los gastos de operación, que a su vez se ven incluidos los factores de licitaciones, importaciones, compras tácticas, compras estratégicas, así como los tipos de inventarios que se pueden desarrollar con los proveedores.
Pedimentos aduanales con identificadores inexactos: una revisión de literatura
Authors: Castillo Nevárez Nohemí , Alamilla Ocaña Luis Jesús , Anaya Carrasco José Luis , Portillo Castillo Victor Manuel , Mendoza Giner Lorena
Published: November 2024

Las operaciones de comercio exterior de México, exigen una serie requisitos legales para dar cumplimiento al despacho aduanero regulado por la Ley Aduanera (LA) y su reglamento, leyes complementarias y relacionadas. Una de esas formalidades consiste en un documento electrónico muy importante que recibe el nombre de pedimento, donde van plasmados los identificadores aduanales, de tal manera que, dicho documento acredita el estatus legal en sus diferentes modalidades de las mercancías con respecto al territorio nacional.
Dentro del pedimento, los identificadores van declarados a nivel general y partida, son claves de dos dígitos alfanuméricos; y pueden tener hasta 3 complementos según sea indicado. Son alrededor de 150, los cuales están listados en el Apéndice 8 del Anexo 22 de las Reglas Generales de Comercio Exterior (RGCE).
El artículo en cuestión presenta una revisión de la literatura queda sustento al objeto de investigación, reservando para una segunda publicación los resultados finales que se obtengan, mismo que tiene como objetivo conocer la importancia de los identificadores aduanales a nivel general y a nivel partida, y a su vez identificar la posible causa por lo cual se cometen errores al momento de su captura, y dar a conocer los posibles gastos por concepto de multas por datos inexactos, que puede tener una empresa por la omisión de estos y plantear una  estrategia que permita reducir dichos errores, en el futuro. Para ello, se realizó una búsqueda sistemática de artículos científicos sobre los temas mencionados en diversas bases de datos electrónicas entre los años 2006 al 2022. La revisión permitió identificar 83 artículos, de los cuales solo 21 fueron seleccionados para lo que aquí se presenta.
PyMES restauranteras y su relación con las plataformas digitales de consumo y la competitividad en el entorno del COVID-19
Authors: De la Rosa Barraza Génesis , Alvarado Tarango Lizette , Gómez Zepeda Perla Ivette , Poblano Ojinaga Eduardo Rafael , López Galván José Luis
Published: November 2024

El presente artículo es una investigación de tipo documental sobre la influencia de plataformas digitales de consumo y los factores clave que hacen competitivas a las PyMES restauranteras ante la contingencia por el COVID-19. El método utilizado fue una revisión sistemática de literatura donde se recopiló la información relevante al tema a través de buscadores confiables, se obtuvo acceso a: libros, artículos de revista, periódico digital, datos analizados previamente, los cuales se sintetizaron para una mejor comprensión lectora. Con la revisión sistemática de la literatura se ha encontrado que los cierres registrados a lo largo de dos años (2020-2022) de las pequeñas y medianas empresas (PyMES) restauranteras se atribuyen a la inestabilidad provocada por la pandemia del COVID-19 así como también 7 de cada 10 PyMES que mudaron sus servicios a través de plataformas digitales siguen vigentes en el mercado. En conclusión, una empresa competitiva requiere de la aplicación de la tecnología como herramienta para crecer y perdurar en el mercado adaptándose al entorno que le rodea, donde deberá explotar al máximo sus capacidades y tener el valor de reinventarse.