bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical analysis of laser-welded flange pipe joints in lap and fillet configurations
Authors:   Kielce University of Technology, Danielewski Hubert ,   Faculty of Mechatronics and Mechanical Engineering, Skrzypczyk Andrzej , Zowczak Włodzimierz , Gontarski Dariusz , Płonecki Leszek , Wiśniewski Hubert , Soboń Dominika , Kalinowski Artur , Bracha Gabriel , Borkowski Krzysztof
Published: January 2022

This article presents a numerical analysis of laser-welded flange pipe joints. The presented results concern the welding of low carbon S235JR and stainless 316L steels using a CO2 laser in lap and fillet joint configurations. The estimation of welding parameters was achieved using Simufact Welding software and numerical simulation, where output power, feed rate, efficiency and intensity distribution (Gaussian parameter) were analysed. In accordance with the established model, a thermo-mechanical simulation was performed. The calculated joint geometries show good agreement with experiments; therefore, the obtained results were used to study selected joint properties of both joint types. Stress-strain distribution was estimated on the basis of thermomechanical analysis. Weld bead geometry obtained from numerical simulation was compared with the results from trial joints. The numerical model established for both joint configurations shows good agreement with experimental results and were assumed to be accurate. The results of the performed analysis shown some advantages of the use of this configuration of lap joints in flange pipe joints.
Extended Investigation on the connection of TP73 G4C14-A4T14 Polymorphism with different Cancer Types – An Updated Meta-analysis with 56 Case-control Studies
Authors:   Noakhali Science and Technology University, Jafrin Sarah , Aziz Md. Abdul , Islam Mohammad Safiqul
Published: January 2022

Review question / Objective: TP73 G4C14-A4T14 variant has been suspected of elevating the risk of cancer for many years. The available evidence was unsatisfactory and could not provide a reliable conclusion. Therefore, we performed this meta-analysis to re-evaluate the previous findings and illustrate the actual role of TP73 G4C14-A4T14 variant on cancer development. Condition being studied: The association of the G4C14-A4T14 variant with cancer risk was studied. Information sources: PubMed, Google Scholar, EMBASE, Cochrane Library, and Web of Science, CNKI.
En los confines de la Oretania : el oeste de la provincia de Albacete y el establecimiento del área de influencia
Authors: Manzaneda Martín Cristina
Published: January 2022

La provincia de Albacete, a nivel geográfico, configura el Sureste de la Meseta, aspecto que le confiere una ubicación más que significativa en el interior peninsular, pues se encuentra a caballo entre las tierras valencianas, el Valle del Segura y la Andalucía Oriental. Es decir, en época ibérica se encontraba en contacto directo con los principales pueblos ibéricos, edetanos, contestanos, bastetanos, etc. En estas páginas el autor se centra en el pueblo oretano. Este grupo ibérico constituyó uno de los pueblos prerromanos más destacados, habiendo jugado un papel determinante en los procesos históricos, especialmente aquellos que tuvieron como escenario la Península Ibérica entre finales del siglo III y el I a.C. Su interés les ha llevado a ser objeto de numerosos estudios desde enfoques diversos, lo que ha provocado un conocimiento parcial y sesgado de esta etnia perteneciente al mundo ibérico.
A kriminalisztikai célú adatgyűjtés, az elektronikus Modus Operandi Nyilvántartás jövője és kutatási lehetőségei
Authors: Juhász Gyöngyike
Published: January 2022

The aim of the present study is to describe the possibilities inherent to the Modus Operandi Register, which are achievable by a symbiosis of the theoretical and practical approaches. The study presents the history of the Modus Oprandi registry, its operating principle, the forensic meaning of perseverance, and the range of data managed in the registry. It provides insight into the future of the electronic Modus Operandi Register through insight into forensic data collection at the police, which may include, for example, the application of artificial intelligence, research on perseverance, or the investigation of criminal life paths.
ANALYSIS OF BIM AND MCDM INTEGRATION IN DESIGN, MANUFACTURING AND CONSTRUCTION STAGES
Authors: Zigmund Viačeslav
Published: January 2022

The article analyses the possibilities of synergy between MCDM (Multi Criteria Decision Making) methods and BIM (Building Information Modeling) technologies in order to identify a better integration way and propose a strategy for integrating MCDM and BIM. The two ways of integration were identified after performing literature analysis – the linear one and integrated one. The stages of the integration strategy were discussed and a key strategy for improving the synergy between MCDM and BIM was found. The key strategy intended for masonry veneer and masonry structures in design, manufacture and construction stages to make a decision.
FEM ANALYSIS OF ENERGY LOSS DUE TO WAVE PROPAGATION FOR MICRO-PARTICLE IMPACTING SUBSTRATE WITH HIGH VELOCITIES
Authors: Jočbalis Giedrius
Published: January 2022

The impact between particles and material surface is a micro-scaled physical phenomenon found in various technological processes and in the study of the mechanical properties of materials. Design of materials with desired properties is a challenging issue for most industries. And especially in aviation one of the most important factors is mass. Recently with the innovations in 3D printing technologies, the importance of this phenomenon has increased. Numerical simulation of multi-particle systems is based on considering binary interactions; therefore, a simplified but as much accurate as possible particle interaction model is required for simulations. Particular cases of axisymmetric particle to substrate contact is modelled at select impact velocities and using different layer thicknesses. When modelling the particle impact at high contact velocity, a substrate thickness dependent change in the restitution coefficient was observed. This change happens is due to elastic waves and is important both to coating and 3D printing technologies when building layers of different properties materials.
Stochastic Low-frequency Variability in Three-dimensional Radiation Hydrodynamical Models of Massive Star Envelopes
Authors: Schultz William C. , Bildsten Lars , Jiang 姜燕 Yan-Fei 飞
Published: January 2022

Increasing main-sequence stellar luminosity with stellar mass leads to the eventual dominance of radiation pressure in stellar-envelope hydrostatic balance. As the luminosity approaches the Eddington limit, additional instabilities (beyond conventional convection) can occur. These instabilities readily manifest in the outer envelopes of OB stars, where the opacity increase associated with iron yields density and gas-pressure inversions in 1D models. Additionally, recent photometric surveys (e.g., TESS) have detected excess broadband low-frequency variability in power spectra of OB star lightcurves, called stochastic low-frequency variability (SLFV). This motivates our novel 3D Athena++ radiation hydrodynamical (RHD) simulations of two 35 M
⊙ star envelopes (the outer ≈15% of the stellar radial extent), one on the zero-age main sequence and the other in the middle of the main sequence. Both models exhibit turbulent motion far above and below the conventional iron-opacity peak convection zone (FeCZ), obliterating any “quiet” part of the near-surface region and leading to velocities at the photosphere of 10–100 km s−1, directly agreeing with spectroscopic data. Surface turbulence also produces SLFV in model lightcurves with amplitudes and power-law slopes that are strikingly similar to those of observed stars. The characteristic frequencies associated with SLFV in our models are comparable to the thermal time in the FeCZ (≈3–7 day−1). These ab initio simulations are directly validated by observations and, though more models are needed, we remain optimistic that 3D RHD models of main-sequence O-star envelopes exhibit SLFV originating from the FeCZ.
Pure rolling motion of hyperquadrics in pseudo-Euclidean spaces
Authors: Marques André , Leite Fátima Silva
Published: January 2022

This paper is devoted to rolling motions of one manifold over another of equal dimension, subject to the nonholonomic constraints of no-slip and no-twist, assuming that these motions occur inside a pseudo-Euclidean space. We first introduce a definition of rolling map adjusted to this situation, which generalizes the classical definition of Sharpe [26] for submanifolds of an Euclidean space. We also prove some important properties of these rolling maps. After presenting the general framework, we analyse the particular rolling of hyperquadrics embedded in pseudo-Euclidean spaces. The central topic is the rolling of a pseudo-hyperbolic space over the affine space associated with its tangent space at a point. We derive the kinematic equations, as well as the corresponding explicit solutions for two specific cases, and prove the existence of a rolling map along any curve in that rolling space. Rolling of a pseudo-hyperbolic space on another and rolling of pseudo-spheres are equally treated. Finally, for the central theme, we write the kinematic equations as a control system evolving on a certain Lie group and prove its controllability. The choice of the controls corresponds to the choice of a rolling curve.
MBJ-neutrosophic subalgebras and filters in $ BE $-algebras
Authors: Borzooei Rajab Ali ,   Department of Mathematics, Shahid Beheshti University, Tehran 1983963113, Iran, Kim Hee Sik , Jun Young Bae , Ahn Sun Shin ,   Department of Mathematics, Hanyang University, Seoul 04763, Korea,   Department of Mathematics Education, Gyeongsang National University, Jinju 52828, Korea,   Department of Mathematics Education, Dongguk University, Seoul 04620, Korea
Published: January 2022

The concept of a neutrosophic set, which is a generalization of an intuitionistic fuzzy set and a para consistent set etc., was introduced by F. Smarandache. Since then, it has been studied in various applications. In considering a generalization of the neutrosophic set, Mohseni Takallo et al. used the interval valued fuzzy set as the indeterminate membership function because interval valued fuzzy set is a generalization of a fuzzy set, and introduced the notion of MBJ-neutrosophic sets, and then they applied it to BCK/BCI-algebras. The aim of this paper is to apply the concept of MBJ-neutrosophic sets to a $ BE $-algebra, which is a generalization of a BCK-algebra. The notions of MBJ-neutrosophic subalgebras and MBJ-neutrosophic filters of $ BE $-algebras are introduced and related properties are investigated. The conditions under which the MBJ-neutrosophic set can be a MBJ-neutrosophic subalgebra/filter are searched. Characterizations of MBJ-neutrosophic subalgebras and MBJ-neutrosophic filters are considered. The relationship between an MBJ-neutrosophic subalgebra and an MBJ-neutrosophic filter is established.
Convergence of the Deep BSDE method for FBSDEs with non-Lipschitz coefficients
Authors: Jiang Yifan , Li Jinfeng
Published: January 2022

This paper is dedicated to solving high-dimensional coupled FBSDEs with non-Lipschitz diffusion coefficients numerically. Under mild conditions, we provided a posterior estimate of the numerical solution that holds for any time duration. This posterior estimate validates the convergence of the recently proposed Deep BSDE method. In addition, we developed a numerical scheme based on the Deep BSDE method and presented numerical examples in financial markets to demonstrate the high performance.
On the laws of the iterated logarithm under sub-linear expectations
Authors: Zhang Li-Xin
Published: January 2022

In this paper, we establish some general forms of the law of the iterated logarithm for independent random variables in a sub-linear expectation space, where the random variables are not necessarily identically distributed. Exponential inequalities for the maximum sum of independent random variables and Kolmogorov’s converse exponential inequalities are established as tools for showing the law of the iterated logarithm. As an application, the sufficient and necessary conditions of the law of the iterated logarithm for independent and identically distributed random variables under the sub-linear expectation are obtained. In the paper, it is also shown that if the sub-linear expectation space is rich enough, it will have no continuous capacity. The laws of the iterated logarithm are established without the assumption on the continuity of capacities.
“Bundle of Sticks” and the Value of Interdependence: Building a Tools and Services Collective
Authors: Skinner Katherine Elizabeth , Mitchell Catherine , Ratan Kristen
Published: January 2022

In this article, we raise questions about how bundling and independence show up in the scholarly publishing industry today, both for large conglomerates and for smaller commercial and nonprofit players. We then contemplate what interdependence might look like and how it might help to transform academic publishing. We end with findings from the Next Generation Library Publishing (NGLP) project (2019-2022) and its Collaborative Frameworks Working Group regarding a set of initial steps that we believe publishers, tools, and service providers might take together towards developing a collective publishing framework for open source, values-aligned tools and services.
Caring for our communities of practice in educational development
Authors: Chen Christopher V.H.-H. , Kearns Katherine , Eaton Lynn , Hoffmann Darren S. , Leonard Denise , Samuels Martin
Published: January 2022

Given the backdrop of multiple concurring crises—a global pandemic, political instability and violence, and multiple structural inequalities—we see the problem of now as this: How do educational developers continue to address the wicked problems in teaching and learning when we are simply so exhausted? Our article presents the importance of communities of practice for educational developers, inviting us to witness and name the communities in which we belong; the important functions they engage; who they nurture and how; and what care is undertaken to sustain these groups and ourselves. To help educational developers understand and appreciate the ways that communities of practice support our work (emotionally, professionally, and socially), we share a framework from the literature of organizational management and apply it to communities in educational development. We include narratives to demonstrate this framework in action to amplify the particularly important role these groups have played in our professional and personal lives. We end with actions we can take to care for our communities of practice that build upon the presented theoretical foundation. As these groups are fragile, maintaining our communities is important so that they will provide us support and shelter into the post-pandemic future.
Influence of Corporate Sustainability on Providing Electronic Payment Services by the Banking Industry in India
Authors: Sharma Shweta , Agarwal Aakanksha
Published: January 2022

This study investigates the role of sustainable finance practices and their impact on digital banking services in India. An increased frequency of internet use for various digital banking services provides an opportunity to build the banking industry with various online services. This study reviews the literature on sustainable corporate finance and the adoption of e-banking services. The study uses an exploratory research-based approach to understand the usage rate and adoption of internet banking. A questionnaire-based survey was conducted on 325 respondents. Findings of the study suggest that there is a gradual increase in the adoption of internet banking, but major barriers in adoption are a threat of security, privacy, and trust.
Recycling Behaviour of Urban Households in the Vietnamese Mekong Delta
Authors: Xuan Huynh Thi Dan , Khong Tien Dung , Khai Huynh Viet
Published: January 2022

This chapter is aimed at providing new insights into the perception and determinants of municipal solid waste behaviour. A quantitative data set was obtained and analyzed by directly interviewing 579 urban households in in the Vietnamese Mekong Delta stratified by urban-type level. Binary Probit model and OLS regression indicate the significant influences of urbanization level, organization membership, the concern to environmental status, and education level of households. Finally, results reveal that the municipal solid waste recycling level can be significantly increased by motivating urban households' incentives; therefore, policymakers in Vietnam as well as in developing countries should also provide more incentive to households by subsidizing the recycled materials (i.e., paper and unusable metal) and well-managed informal recycling systems including itinerant waste buyers.
Securing Cloud Virtual Machine Image Using Ethereum Blockchain
Authors: Basu Srijita , Karmakar Sandip , Bera Debasish
Published: January 2022

Virtual Machine Image (VMI) is the building block of cloud infrastructure. It encapsulates the various applications and data deployed at the Cloud Service Provider (CSP) end. With the leading advances of cloud computing, comes the added concern of its security. Securing the Cloud infrastructure as a whole is based on the security of the underlying Virtual Machine Images (VMI). In this paper an attempt has been made to highlight the various risks faced by the CSP and Cloud Service Consumer (CSC) in the context of VMI related operations. Later, in this article a formal model of the cloud infrastructure has been proposed. Finally, the Ethereum blockchain has been incorporated to secure, track and manage all the vital operations of the VMIs. The immutable and decentralized nature of blockchain not only makes the proposed scheme more reliable but guarantees auditability of the system by maintaining the entire VMI history in the blockchain.
Legacies and pitfalls amongst the African Evangelicals: A Kenyan experience from a historical perspective
Authors: Gathogo Julius M.
Published: January 2022

The research study sets out to explore the contribution of the African Evangelicals in both the colonial and post-colonial Kenya to the social lives of the nation. Can’t it be viewed as a positive social influence or an ecclesiastical pitfall? In utilising a socio-historical design, it poses the question: how did the Evangelical European Missionaries demonstrate their theological and social influences in Kenya, and how did the post-missionary Evangelical-leaning leaderships play out? And was Muthirigu Dance an extremist reaction against the rigidity of the Evangelicals? Methodologically, this article will attempt to explore the Evangelical European Missionary Christianity, especially the Church Missionary Society that entered Central Kenya in the early 1900s, and assess the way in which they handled indigenous cultures of the local Africans. It has also attempted to critically explore their social influences in both colonial and post-colonial Kenya (1895–2021). The CMS has been given more emphasis in this article as an Evangelical society so as to help in bringing out the specific Evangelical activities in the Kirinyaga County of Kenya. Overall, the article has endeavoured to hypothesise that Eurocentrism was not the Evangelical problem, as there were diverse European missionaries, such as the High Anglican Church, the Roman Catholic and the Lutherans who were non-Evangelicals, and who were not necessarily dogmatic and rigid.Contribution: This study adhered to the HTS journal’s vision and scope by its focus on the histories of the Evangelical European Missionaries of the 19th and 20th centuries, their interactions with the local religio-cultures, and how it later played out amongst the Africans.
Antistaphylococcal effects of alcoholic extracts of Tetrapleura tetraptera (Schum and Thonn.) (Taub.) against multidrug methicillin resistant Staphylococcus aureus
Authors: Adeoye-Isijola Morenike O. , Naidoo Kubendran K. , Coopoosamy Roger M. , Olajuyigbe Olufunmiso O.
Published: January 2022

Background: Staphylococcus aureus is a pathogen causing life-threatening hospital and community-acquired infections with high morbidity and mortality rates requiring constant vigilance.Aim: This study aimed at investigating the antistaphylococcal effects of Tetrapleura tetraptera against different strains of multidrug methicillin resistant S. aureus (MRSA) to indicate the need for its use in ethnomedicine in addition to its fruits being used in traditional medicine.Methods: In this study, the susceptibilities of S. aureus were investigated using multi-disc antibiotics and extracts of T. tetraptera by agar diffusion and macrobroth dilution methods.Settings: While attention has been focused on the fruits of this plant, it is necessary to investigate the pharmacological importance of its stem bark.Results: The antibiogram showed that 70% of the isolates were multidrug resistant. Nitrofurantoin and gentamicin antibiotics were the most effective whilst amoxicillin and augumentin were the least effective. The susceptibility of the isolates was concentration dependent as inhibition zones decreased with decrease in the concentrations of each of the extracts. The minimum inhibitory concentrations (MICs) of acetone extract ranged between 0.019 mg/mL and 20 mg/mL whilst the minimum bactericidal concentrations (MBCs) ranged between 0.3125 mg/mL and 20 mg/mL. The MICs of the methanol extract ranged between 0.039 mg/mL and 5.0 mg/mL whilst the MBCs ranged between 0.3125 mg/mL and 10 mg/mL. Both extracts were more bactericidal than being bacteriostatic against all the isolates. The methanol extract was more active than the acetone extract as indicated by the varied inhibition zones and MICs obtained from the different extracts.Conclusion: This study revealed the great therapeutic potentials of T. tetraptera and validated its use in ethnomedicine and would be effective in the treatment of multidrug and MRSA infections.
Transgenders are the most vulnerable amongst individuals engaging in receptive anal intercourse
Authors: Arora Tanvi , Wadhwa Neelam , Pandhi Deepika , Diwaker Preeti , Arora Vinod K.
Published: January 2022

Background:

In India, sexuality not confirming to hetero-conjugal and peno-vaginal norm is abhorred and discriminated against. Individuals engaging in Receptive Anal Intercourse (RAI) are marginalized. Reappraisal of their sexual health conditions is likely to promote inclusive health care.

Methods:

Eighty-five consenting adults with RAI history were recruited from a tertiary care hospital in Delhi. Clinico-demographic data was noted and anal cytology samples were reported by Bethesda 2014 terminology.

Results:

There were 29 transgenders (TGs), 51 males (31 bisexual) and five females. Fifty-four subjects were Human Immunodeficiency Virus (HIV) infected (22 TGs, 31 males (17 bisexual) and one female) and 52 were receiving anti-retroviral treatment (ART). Thirty-one subjects had anal warts (6 TGs, 20 males, five females). Anal cytology revealed squamous intra-epithelial lesions (SIL) in 20 (5 TGs, 13 males, two females). TGs had significantly risker sexual practices than homosexual males, bisexual males and females, with consistently earlier age of first RAI exposure and frequent childhood (≤16 years) RAI experience compared to homosexual males, bisexual males and females, even after stratification by HIV status, warts and SIL.

Conclusions:

TGs had the highest sexual health risk profile including higher frequency of HIV infection compared to other subjects with RAI history. Bisexuality was common; their risk profile was variably lower than homosexual males. Mindfulness of above is likely to help overcome barriers to health care access and promote compassionate approach at all levels including primary care physicians.
Aspectos éticos de los protocolos de actuación en interpretación telefónica
Authors: Lázaro-Gutiérrez Raquel , Iglesias-Fernández Emilia , Cabrera-Méndez Gabriel
Published: January 2022

La modalidad de la interpretación telefónica está adquiriendo cada vez más importancia en los servicios públicos de España debido a las numerosas ventajas que ofrece. Fernández Pérez (2012) estableció una clasificación de las habilidades particulares que los intérpretes telefónicos deben adquirir según sus dos funciones principales: la función de coordinación del discurso y la función de traducción. Además de estas habilidades, es imprescindible que los intérpretes telefónicos conozcan en profundidad y sigan escrupulosamente los protocolos que se diseñan y desarrollan para los distintos clientes de interpretación telefónica, como aquellos que se utilizan para las líneas de emergencia. El objeto de estudio de esta contribución lo constituyen, precisamente, estos protocolos de actuación. Nuestro punto de partida son las especificaciones que deben hacerse sobre la actuación de los intérpretes, que con frecuencia divergen de o, incluso, contradicen los principios éticos más comunes, como la fidelidad o la neutralidad. Este estudio consiste en un análisis minucioso de los protocolos utilizados en la empresa Dualia Teletraducciones y en una reflexión crítica desde una perspectiva ética sobre los ajustes que se sugieren en ellos a propósito del rol tradicional del intérprete.
Manel Lacorte, Agustín Reyes Torres (2021). Didáctica del español como 2/L en el siglo XXI
Authors: Šifrar Kalan Marjana
Published: January 2022

El Instituto Cervantes viene publicando este libro de referencia sobre el español desde hace 22 años, pero en sus primeros informes, a partir del año 1998, la demolingüística todavía no incluía el número de los alumnos. Los datos que demuestran el crecimiento de la presencia del español en el mundo entero son indudablemente impresionantes y lo es también el crecimiento de las publicaciones dedicadas al campo del español como lengua extranjera y segunda lengua que trata de seguir esta evolución. Didáctica del español como 2/L en el siglo XXI, el reciente manual de formación de profesores de español como 2/L viene a cubrir y actualizar el desarrollo en este campo. Los autores, Manel Lacorte y Agustín Reyes-Torres, transcienden con este monográfico su conocimiento y experiencia adquiridos a lo largo de casi treinta años de su carrera como profesores e investigadores de 2/L.
La traducción y la interpretación a la luz de la ética y la responsabilidad social
Authors: Markič Jasmina , Geršak Marija Uršula
Published: January 2022

Este número temático de Verba Hispanica pretende ampliar temas sobre la re­lación entre la ética, la responsabilidad social y la traducción e interpretación, el papel de la traducción e interpretación en su comprensión mutua y en la comunicación intercultural, la importancia de la formación y la educación a la luz de la responsabilidad social y la ética tanto del punto de vista teórico como del de la perspectiva práctica, y también la importancia de la traducción lite­raria como medio de conocimiento y respeto de diferentes culturas y lenguas.
Antibiotic use in Moshi Urban: A cross-sectional Study of Knowledge and Practices among Caretakers of Children in Kilimanjaro Tanzania
Authors: J Petro Benedicto , Isdory Mkumbaye Sixbert , Rajab Bakar Rukia , Is-hak Yussuf Nassra , Horumpende Pius G. , Mawazo Akili , Charles Kajeguka Debora
Published: January 2022

IntroductionAntibiotics are commonly accessed and used for the management of illness in children without a prescription. We investigated the caretaker’s knowledge and practices on antibiotics and antibiotics use to their children.MethodThis was the hospital-based cross-sectional study conducted from April to July 2017 in three facilities located in Moshi Municipality. A convenience sampling was employed to select for caretakers with their sick children at KCMC, Mawenzi hospital, and Longuo dispensary. Face-to-face interviews were conducted with 224 caretakers who had visited health facilities with their children seeking health care.ResultsThe majority (87.9%, 197/224) of all interviewed caretakers had good knowledge of the use of antibiotics. Irrespective of knowing that it is not safe to self-medicate a child with any antibiotics (95.1%, 213/224), most (61.6%, 138/224) caretakers practiced self-medication with the medicines. Having two children (aOR = 7.75, 95% CI: 1.89-31.67) and having three children (aOR=7.23, 95%CI: 1.08-48.51) were significantly associated with good knowledge of antibiotics.ConclusionThis study has revealed that caretakers in Moshi had a good knowledge of antibiotic use. However, despite such good knowledge, malpractices were observed. We call upon the use of media campaigns to advocate for the importance of the rational use of antibiotics and its effect on human health and the risk of antimicrobial resistance development.Rwanda J Med Health Sci 2021;4(3):347-356
In vitro antiplasmodial, cytotoxic and antioxidant effects, and phytochemical constituents of eleven plants used in the traditional treatment of malaria in Akwa Ibom State, Nigeria
Authors: Eseyin Olorunfemi Abraham , Etim Iweh Emmanuel , Attih Emmanuel E. , Johnson Ekarika , Udobre Aniefiok Sunday , Ebong Aniekan Stephen , Zofou Dennis
Published: January 2022

Purpose: To evaluate the antiplasmodial effects of eleven plants (Bombax buonopozense, Carica papaya, Anthocleista djalonensis, Milicia excelsa, Heterotis rotundifolia, Homalim letestui, Starchystarpheta cayennnensis, Ocimum gratissimum, Cleistopholis patens, Chromolaena odorata and Hippocratea africana) reportedly used in the treatment of malaria in Akwa Ibom State of Nigeria.

Methods: Phytochemical analysis was done by standard methods, while in vitro antiplasmodial evaluation was carried out using Plasmodium falciparum chloroquine-sensitive and chloroquineresistant strains using lactate dehydrogenase (pLDH) assay.  Cytotoxicity test was undertaken by MTT assay on LLC-MK2 cells and the concentration killing 50 % of the cells (CC50) was calculated.Antioxidant activity of the ethanol extract was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.

Results: Milicia excelsa, Heterotis rotundifolia and Chromolaena odorata had moderate antiplasmodial activity. Ocimum gratissimum and Hippocratea africana were weakly active. Milicia excelsa showed a considerable level of cytotoxicity, while Bombax buonopozense exhibited moderate cytotoxicity. Bombax buonopozense (95.3 %) and Ocimum gratissimum (92.0 %) exhibited high DPPH scavengingeffect comparable to Vitamin C (98.7 %). There was a significant correlation (p < 0.05) between DPPH inhibition and the total phenolic contents of the eleven plants studied (r2 = 0.6616), between DPPH inhibition and flavonoids (r2 = 0.3553), between antiplasmodial activity and saponin content (r2= 0.3992), and between the two antiplasmodial evaluation assay methods (r2 = 0.614).Conclusion: The results of this work provide some justification for the use of Milicia excelsa, Heterotis rotundifolia, Chromolaena odorata, Ocimum gratissimum and Hippocratea africana in the treatment of malaria.

Keywords: Antiplasmodial, Antioxidant, Cytotoxicity, Phytochemicals, Antimalaria
Assessment of medication prescription errors and their contributory factors in major cities of Punjab Province, Pakistan: A cross-sectional survey
Authors: Majeed Abdul , Hussain Iltaf , Akbar Muqarrab , Chaudhry Muhammad O. , Imran Imran , Saeed Hamid , Hashmi Furqan K. , Siddique Omama , Tahir Shehnoor , Bilal Sana , Ashraf Fazila , Ayaz Mehvish , Rasool Muhammad F.
Published: January 2022

Purpose: To evaluate the prescription errors and their contributory factors in Punjab, Pakistan.Methods: An observational, cross-sectional study was conducted in 12 major cities of Punjab, Pakistan. A total of 1,184 prescriptions were collected from patients using a convenient sampling method from homes, pharmacies, clinics, and hospitals. The data were presented in frequency and percentage using descriptive statistics. To determine the association between the variables assessed, Chi-square (X2) test was used.Results: A total of 1,184 prescriptions were analyzed; 432 of them (36.5 %) were from prescribers who are graduate degree holders, and 752 (63.5 %) from prescribers who are post-graduate degree holders. The most commonly missing parameters in the prescriptions were the age of the patients (835 representing 29.4 %), signatures of the prescribers (755 representing 26.5 %), and prefix (622 representing 21.9 %). The number of prescription errors was significantly correlated to prescriber qualification (p = 0.001). The prescription errors were more common in age groups of prescribers: 21 - 30 years (654 representing 23.0 %), and 31 - 40 years (1,012 representing 35.6 %) (p = 0.001). The higher number of prescription errors by post-graduate prescribers working in teaching hospitals can be attributed to the higher patient load and lack of continuing medical education programs for the prescribers.Conclusion: The government should take necessary measures for the implementation of electronic prescribing systems, and devise mechanisms for the uniform distribution of patient load amongst the prescribers working in different hospitals.

Keywords: Prescription error, Prescribers, Patient load, Continuing medical education, Electronic prescribing
Determination of dehydroepiandrosterone in dietary supplements by reversed-phase HPLC
Authors: Tabaza Yahia Z. , Mansi Kamal M. , Azzam Hanan A. , Al-Mamoori Farah F. , Al-Samydai Ali M. , Aburjai Talal A.
Published: January 2022

Purpose: To develop a reversed phase high performance liquid chromatography (HPLC) method for the determination of dehydroepiandrosterone (DHEA) in dietary supplements.

Methods: A reversed-phase high performance liquid chromatography (HPLC) method was developed for the determination of DHEA in dietary supplements. An isocratic system consisting of methanol and water (70:30 v/v) was run at a flow rate of 1 mL/min on a C18 HPLC column to achieve the separation. The method was validated with regard to linearity, intra-day and inter-day precision, and limits of both detection and quantification.

Results: The method achieved a retention time of 10.8 min, a resolution of 4.12, a detection limit (LOD) of 50 ng/μL, a quantification limit (LOQ) of 166.7 ng/μL and a label claim of 108.6 % with a relative standard deviation (RSD) of 0.38 % over a range of 0.0625 – 0.50 mg/mL with a correlation coefficient of 0.9997.

Conclusion: The method is simple, cost effective, time-saving and reliable for determining DHEA when compared to other reported methods in literature. Thus, it will be of benefit to manufacturers of this dietary supplement to adopt the method for quantitative laboratory analysis.
Effect of miR-384-targeting LINC00491 on proliferation, migration and invasion of tongue squamous cell carcinoma cells
Authors: Deng Yun , Luo Zhiwei , Feng Peilin , Wang Shuai
Published: January 2022

Purpose: To investigate the effect of long-chain non-coding RNA LINC00491 (LncRNA LINC00491) on the proliferation, migration and invasion of tongue squamous cell carcinoma (TSCC) cells, and the underlying mechanism.

Methods: Real-time quantitative polymerase chain reaction (qRT-PCR) was applied to determine the expressions of LINC00491 and micro-RNA-384 (miR-384). Furthermore, LINC00491 and miR-384 were transfected into CAL-27 cells, while cell cycle was analyzed using flow cytometry. Cell proliferation was determined by methyl thiazolyl diphenyl-tetrazolium (MTT) assay. Cell migration and invasion were evaluated using Transwell experiments. The relationship between LINC00491 and miR-384 was confirmed using double luciferase reporting assay, while protein expression levels of P21, Ki67, E- cadherin, N-cadherin, and vimentin were assayed with Western blotting.

Results: The expression of LINC00491 increased in TSCC tissues (p < 0.05). The proportion of cells in G1-phase increased, while the proportion of cells in S-phase decreased (p < 0.05). There was decrease in cell survival, cell migration and cell invasion (p < 0.05). The protein expression levels of Ki67, N- cadherin, and vimentin were lowered, while those of P21, E-cadherin protein were increased (p < 0.05). Transfection of LINC00491 and miR- 384 reduced the proportion of cells in G1 phase, but increased the proportion of cells in S-phase (p < 0.05). Moreover, cell survival, migration and invasion were increased. The protein expressions of Ki67, N-cadherin, and vimentin rose, while those of P21 and E-cadherin decreased (p < 0.05).

Conclusion: LINC00491 promotes the proliferation, migration and invasion of TSCC cells by inhibiting miR-384. This finding provides a potential target for the treatment of TSCC.
Nowe siedziby instytucji kultury w Polsce – perspektywa lokalnych ekosystemów kultury
Authors: Poprawski Marcin
Published: January 2022

New venues of Cultural Institutions in Poland — the Perspective of Local Cultural Ecosystems Building new venues for cultural activity involves a shift in the balance of power in the entire sys­tem of relations in the local communities of authors and organisers. This is a matter of budget and, very often, also of cultural policy priorities. Furthermore, it entails a significant change in the long-term funding of cultural initiatives and cultural entities in each region. The phenomenon of the emergence of many new cultural facilities has inspired a few fundamental questions about their at­titudes to selected values in the field of sustainable development goals, particularly in the social and economic dimensions, but ultimately also of the impact of new cultural venues on the natural en­vironment. Are the new investments in culture opportunities, challenges, or perhaps threats result­ing from the rescaled or disturbed balance in local cultural ecosystems? The theoretical perspective, which organises the debate on these areas, takes the cultural ecosystem as a key concept, using it as a basis for the description of phenomena in local urban communities. The observations present­ed are based on the qualitative and quantitative research conducted in eight cultural institutions in eight Polish cities. The results reveal the importance of between ten and twenty fundamental di­mensions of the activity of cultural institutions and their local government organisers which allow them to put down their roots more deeply in the city’s cultural ecosystem. A new building opens completely new possibilities, but it is extremely important to tailor the institution to the real, saga­ciously assessed, and well-balanced possibilities of the local ecosystem.
Zrównoważona produkcja filmowa w Polsce. Geneza i perspektywy
Authors: Wróblewska Anna
Published: January 2022

Sustainable Film Production in Poland. The Origin and Prospects

The 21st century has seen a growing awareness of the serious impact of film and television production on the natural environment. The film industry pollutes our environment in many ways, including carbon dioxide emissions, waste production, and energy and water consumption. The initiatives for sustainable development undertaken in many sectors of the economy have also reached the film industry. In Europe and the United States, various organisations and institutions have developed a number of recommendations in the field of sustainable film production. This paper, set in the film studies trend known as production culture, presents the global context as well as the nascent Polish practices of green filming. These initiatives, based on European examples, have so far been mainly bottom-up and dispersed or in the form of non-binding recommendations. The handful of producers and authors who have undertaken them are not in any way encouraged to be eco-friendly. Driven by their concern for the environment, however, they show the forward-looking way of thinking that should be followed by the entire industry.
Powstanie domu akademickiego przy Wałach Leszczyńskiego 6
Authors: Heruday-Kiełczewska Magdalena
Published: January 2022

Uniwersytet Poznański, powstały w 1919 r., szybko odczuł potrzebę powstania domu akademickiego dla przybywających do Poznania studentów. W latach 1925-1929, wysiłkiem Poznańskiego Komitetu Wojewódzkiego do Spraw Pomocy Polskiej Młodzieży Akademickiej, przy Wałach Leszczyńskiego powstał istniejący do dziś gmach (obecnie akademik „Hanka” przy al. Niepodległości), w którym mieściły się studenckie pokoje oraz pomieszczenia, takie jak czytelnia, kaplica czy stołówka. Budowa domu była inicjatywą, którą wsparło całe społeczeństwo Wielkopolski, i która przysłużyła się nie tylko młodzieży, ale również posłużyła jako kwatera dla gości przybywających na Powszechną Wystawę Krajową. Pomimo iż w zamyśle właścicielem budynku miał być Uniwersytet. Do 1939 r. nie udało się jednak uregulować kwestii własności, mimo usilnych starań Rektora.

The History of the Dormitory at Wały Leszczyńskiego 6

Poznań University was established in 1919 and it quickly became clear that it was necessary to build dormitories for incoming students. Between 1925 and 1929, with the efforts of Poznań Voivodeship Committee for Helping Young Polish Students, the building that exists until the present day (now “Hanka” dormitory at Aleje Niepodległości) was built at Wały Leszczyńskiego. It had rooms for students and common rooms, e. g. a reading room, a chapel and a canteen. The construction was an initiative supported by the community of Greater Poland and it catered not only for students’ needs, but also for guests coming to Poznań to see the Polish General Exhibition. Initially, the University was supposed to be the owner of the building. However, until 1939, it was impossible to regulate the ownership, despite Vice-chancellor’s efforts.
Spuścizna prof. Marii Paradowskiej w PAN Archiwum w Warszawie Oddział w Poznaniu
Authors: Jaśkowska Zuzanna
Published: January 2022

W artykule omówiono spuściznę zmarłej w 2011 r. prof. Marii Paradowskiej, długoletniej kierownik Instytutu Archeologii i Etnologii PAN. W poszczególnych paragrafach przedstawiono rodzaje dokumentacji przekazanej do zbiorów PAN Archiwum w Warszawie Oddział w Poznaniu. Najwięcej miejsca poświęcono materiałom o szeroko pojętej tematyce Bambrów, w tym działalności Towarzystwa Bambrów Poznańskich, organizacji corocznego Święta Bamberskiego oraz budowie i funkcjonowaniu otwartego w 2003 r. muzeum zadedykowanego tej społeczności. Kolejna część tekstu skupia się na zebranej przez prof. Paradowską dokumentacji, dotyczącej Polonii latynoamerykańskiej. W grupie tej wyróżniają się materiały na temat życia i działalności ks. Ignacego Posadzego, pierwszego przełożonego Towarzystwa Chrystusowego dla Polonii Zagranicznej. Artykuł, poprzez analizę spuścizny, przybliża zainteresowania badawcze oraz postać samej prof. Paradowskiej.

The Heritage of Professor Maria Paradowska in the Polish Academy of Sciences in Warsaw, Poznan Branch

The article discusses the heritage of the late professor Maria Paradowska (died in 2011), longserving head of the Institute of Archeology and Ethnology of the Polish Academy of Sciences. Each paragraph presents types of documents conveyed to the collection of the Polish Academy of Sciences in Warsaw, Poznań branch. Here, the most broadly discussed are the publications on the Bamberg settlers in Poznań, including materials on the Society of Poznań Bamberg Settlers, the annual organization of the Bamberg Festival, and the creation and operation of the museum dedicated to the Bamberg community in Poznań (opened in 2003). The next part of the text focuses on documentation on Polish emigrants in Central America, gathered by prof. Paradowska. In this group, the materials on life and work of father Ignacy Posadzy (the first superior of the The Society of Christ Fathers for Poles Living Abroad) clearly stand out. The analysis of prof. Paradowska’s heritage reveals not only her research areas, but also her character.
Polacy i Niemcy w geopolitycznej przestrzeni XX w.
Authors: Łukomski Grzegorz
Published: January 2022

Wielowiekowe trudne sąsiedztwo polsko-niemieckie skłania do refleksji nad wzajemną akulturacją, mającą swoje pozytywne i negatywne skutki, splataniem się w naszych dziejach wielkiej polityki i mikrohistorii, ludzkich losów wpisanych w dzieje obu narodów. W przeszłości relacje polsko - niemieckie kreowali nade wszystko intelektualiści i politycy, oni narzucali je społeczeństwom. W niemieckiej praktyce politycznej zagadnienie geopolityki łączyło się z pojęciami: Lebensraum (przestrzeń życiowa), Grossraum (wielka przestrzeń), Blut und Boden (krew i ziemia), Grossraumwirtschaft (gospodarka wielkiej przestrzeni) oraz Mitteleuropa (Europa Środkowa). Ta ostatnia koncepcja, głoszona przez ideologów i polityków niemieckich, miała bardzo istotne znaczenie, dotyczyła stworzenia zdominowanego przez Niemcy obszaru gospodarczego i geopolitycznego. Geopolityka to problem globalny, dotyczy każdego niemal państwa jako organizacji politycznej, której celem jest zapewnienie bezpieczeństwa swym obywatelom. W przypadku Polski, położonej w sercu Europy, realia geopolityczne miały od wieków także bardzo istotny aspekt globalny, który stanowi część rozważań w prezentowanej pracy. Podstawą myślenia geopolitycznego był realizm polityczny, reprezentowany przez środowiska konserwatywne i narodowe. Do nurtu tego zaliczyć należy myśl polityczną ks. Adama Jerzego Czartoryskiego, Aleksandra Wielopolskiego, oraz tradycję krakowskich stańczyków.

Poles and Germans in Geopolitical Reality in the 20th Century

Long, difficult Polish-German neighborhood is an inspiration to reflect upon the mutual acculturation, which has both positive and negative outcomes, and to reflect on how the great politics and micro-history overlapped across our history. It is also aimed to consider individual histories inscribed in the history of both nations. In the past, Polish-German relations were primarily created by politicians and great intellectual minds. They imposed those relations onto society. In the German politics, the notion of geopolitics was related to the notions of Lebensraum (living space), Grossraum (the great space), Blut und Boden (blood and soil), Grossraumwirtschaft (the economy of the great space) and Mitteleuropa (Central Europe). The last one, advocated by some German ideologists and politicians, was of primary significance. It was about creating a German-dominated economic and geopolitical area. Geopolitics is a global issue, it concerns almost every state – a political organization – which aims to provide security for its own citizens. In the case of Poland, a country located in the heart of Europe, for centuries, geopolitical reality has had an important global aspect, which is part of the discussion in the article. Political realism was the foundation of geopolitical thought, and it was represented by the conservative and national circles, e. g. political thought of father Adam Jerzy Czartoryski and Aleksander Wielkopolski and the tradition of Stanczyks from Cracow.