bluuebunny/crossref_metadata_2025 huggingface dataset:
Skills Required to Head Physician for the Management of Staff. Emotions in the Organizational Context
Authors: Mango Lucio , Mango Lucio , Stefano Giuseppe Di
Published: January 2019

This short paper aims to identify the key skills required for personnel management that makes it possible a peaceful business climate and a level of excellence in services rendered. Are analyzed particularly emotional skills like e.g. mindfulnessa
The Unfulfilled Promise of Prokinetics for Functional Dyspepsia/Postprandial Distress Syndrome
Authors: Tack Jan , Van den Houte Karen , Carbone Florencia
Published: January 2019

Functional dyspepsia (FD) is subdivided into epigastric pain syndrome and postprandial distress syndrome according to the Rome IV consensus. Based on the assumption that disordered gastric motility is a key pathophysiologic factor in postprandial distress syndrome, prokinetic agents are often proposed as the treatment of choice for this subgroup. Although a meta-analysis suggests that prokinetic agents may be efficacious and safe in FD, there is a lack of widely available agents of proven efficacy. This review analyzes some of the difficulties and challenges in establishing therapeutic efficacy of prokinetic drugs in FD.
Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?
Authors: Vuppalanchi Raj , Weber Regina , Russell Sarah , Gawrieh Samer , Samala Niharika , Slaven James E. , Harden Lauren , Chalasani Naga
Published: January 2019

OBJECTIVES:

To investigate the effect of meal intake on liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) in patients with biopsy-proven nonalcoholic fatty liver disease undergoing vibration-controlled transient elastography.

METHODS:

LSM and CAP were assessed at baseline and serially for 6 hours after meal intake in 24 patients.

RESULTS:

A significant increase in LSM was seen up to the 2-hour time point (26 ± 25%, P = 0.02). The CAP scores changed minimally with a maximal change of 3% (P > 0.1).

CONCLUSIONS:

Three hours of fasting is necessary before evaluation with vibration-controlled transient elastography.
ISOGEOMETRIC BEAM ELEMENT EXTENDED FOR GRIDSHELL ANALYSIS
Authors: Dvořáková Edita , Patzák Bořek
Published: January 2019

The design of gridshell structures is a complicated process, as the resulting shape of structure depends on initial undeformed grid geometry as well as on the history of boundary conditions used to form the final structure. In practice, the physical model is often used to determine the shape of the structure and the initial grid at the same time. Introducing Isogeometric analysis into a design of gridshells simplifies the design process as the problem can be easily recalculated when initial grid or boundary conditions change and the resulting shape can be immediately illustrated. The presented paper discusses possibilities in isogeometric gridshell modeling and proposes possible solutions of identified problems.
MOLECULAR STATICS SIMULATION OF NANOINDENTATION USING ADAPTIVE QUASICONTINUUM METHOD
Authors: Mikeš Karel , Rokoš Ondřej , Peerlings Ron H. J.
Published: January 2019

In this work, molecular statics is used to model a nanoindentation test on a two-dimensional hexagonal lattice. To this end, the QuasiContinuum (QC) method with adaptive propagation of the fully resolved domain is used to reduce the computational cost required by the full atomistic model. Three different adaptive mesh refinement criteria are introduced and tested, based on: (i) the Zienkiewicz–Zhu criterion (used for the deformation gradient), (ii) local atoms’ site energy, and (iii) local lattice disregistry. Accuracy and efficiency of individual refinement schemes are compared against the full atomistic model and obtained results are discussed.
BIOMECHANICAL EFFECTS OF DECOMPRESSING AND STABILIZING SURGERY FOR LUMBAR DEGENERATIVE DISEASE
Authors: Simonovich Aleksandr Evgenyevich , Gladkov Aleksandr Vjacheslavovich , Cherepanov Evgeny Arkadyevich
Published: January 2019

The paper presents a descriptive kinematic radiographic study of changes in a shape, orientation and function of the lumbar spine in the sagittal plane due to various surgical interventions for lumbar degenerative disease. Literature analysis evidences for only few studies of spine shape and static interrelations in a spinal motion segment after surgical treatment. Any complex assessments of changes in a spine shape in the sagittal plane, its spatial orientation and function after surgical intervention has not been performed. The study includes a comparative kinematic computer analysis of pre- and postoperative radiographs of the lumber spine of 157 patients, including 62 patients after decompression, 50 after posterior interbody fusion, and 45 after dynamic transpedicular fixation. It was found that the overall range of motion has reduced during three years after any kind of surgical intervention; that surgery at the L5–S1 level takes the most significant biomechanical effect; and that decompressing and stabilizing procedures at the L5–S1 level facilitate a lumbar lordosis restoration. The L5–S1 interbody fusion results in interbody space increase and segmental angle decrease at the surgery level. The L4–L5 interbody fusion increases the range of motion in a subjacent motion segment; dynamic transpedicular fixation takes a minimal effect on a lumbar spine shape and vertebral interrelations and allows preserving the physiological mobility of all motion segments.
Operator Popoviciu’s inequality for superquadratic and convex functions of selfadjoint operators in Hilbert spaces
Authors: Alomari Mohammad W.
Published: January 2019

In this work, an operator version of Popoviciu’s inequality for positive operators on Hilbert spaces under positive linear maps for superquadratic functions is proved.
Analogously, using the same technique, an operator version of Popoviciu’s inequality for convex functions is obtained.
Some other related inequalities are also presented.
Nichtlineare modellprädiktive Regelung eines Abwärmerückgewinnungssystems für LKW-Dieselmotoren
Authors: Koppauer Herwig , Kemmetmüller Wolfgang , Kugi Andreas
Published: January 2019

Dieser Beitrag beschreibt die modellprädiktive Regelung (MPC) eines Abwärmerückgewinnungssystems für LKW-Dieselmotoren, welches auf dem Organic Rankine Cycle (ORC) basiert. Zahlreiche Publikationen behandelten bisher die Regelung des Hochdruckteils von ORC-Systemen. Allerdings erfordert der optimale Betrieb des betrachteten Systems auch eine genaue Regelung des Niederdruckteils.

Der Fokus dieser Arbeit liegt daher auf der Erweiterung einer bereits vorgestellten MPC des Hochdruckteils um die optimale Regelung des Niederdruckteils. Die Referenzgrößen für den optimalen Systembetrieb werden aus den Ergebnissen einer stationären Optimierung abgeleitet. Der Test des präsentierten Regelungskonzepts an einem mit Messungen validierten Simulationsmodell zeigt eine ausgezeichnete Folgeregelung der optimalen Referenzgrößen unter Einhaltung der Systembeschränkungen.
Feature selection for spectral clustering: to help or not to help spectral clustering when performing sense discrimination for IR?
Authors: Chifu Adrian-Gabriel , Hristea Florentina
Published: January 2019

Whether or not word sense disambiguation (WSD) can improve information retrieval (IR) results represents a topic that has been intensely debated over the years, with many inconclusive or contradictory conclusions. The most rarely used type of WSD for this task is the unsupervised one, although it has been proven to be beneficial at a large scale. Our study builds on existing research and tries to improve the most recent unsupervised method which is based on spectral clustering. It investigates the possible benefits of “helping” spectral clustering through feature selection when it performs sense discrimination for IR. Results obtained so far, involving large data collections, encourage us to point out the importance of feature selection even in the case of this advanced, state of the art clustering technique that is known for performing its own feature weighting. By suggesting an improvement of what we consider the most promising approach to usage of WSD in IR, and by commenting on its possible extensions, we state that WSD still holds a promise for IR and hope to stimulate continuation of this line of research, perhaps at an even more successful level.
MCT1, MCT4 and CD147 expression and 3-bromopyruvate toxicity in colorectal cancer cells are modulated by the extracellular conditions
Authors: Pereira-Vieira Joana , Azevedo-Silva João , Preto Ana , Casal Margarida , Queirós Odília
Published: January 2019

Monocarboxylate transporters (MCTs) inhibition leads to disruption in glycolysis, induces cell death and decreases cell invasion, revealing the importance of MCT activity in intracellular pH homeostasis and tumor aggressiveness. 3-Bromopyruvate (3BP) is an anti-tumor agent, whose uptake occurs via MCTs. It was the aim of this work to unravel the importance of extracellular conditions on the regulation of MCTs and in 3BP activity. HCT-15 was found to be the most sensitive cell line, and also the one that presented the highest basal expression of both MCT1 and of its chaperone CD147. Glucose starvation and hypoxia induced an increased resistance to 3BP in HCT-15 cells, in contrast to what happens with an extracellular acidic pH, where no alterations in 3BP cytotoxicity was observed. However, no association with MCT1, MCT4 and CD147 expression was observed, except for glucose starvation, where a decrease in CD147 (but not of MCT1 and MCT4) was detected. These results show that 3BP cytotoxicity might include other factors beyond MCTs. Nevertheless, treatment with short-chain fatty acids (SCFAs) increased the expression of MCT4 and CD147 as well as the sensitivity of HCT-15 cells to 3BP. The overall results suggest that MCTs influence the 3BP effect, although they are not the only players in its mechanism of action.
Enhancement the Dynamic Performance of Islanded Microgrid Using a Coordination of Frequency Control and Digital Protection
Authors: Mohamed Emad A. , Mitani Yasunori
Published: January 2019

This paper presents an assortment study between the virtual inertia control (VIC)-based a new optimal PID controller, load frequency control (LFC), and the digital protection for an islanded microgrid (MG) taking into consideration the emerging level of renewable energy resources (RERs), which is a promising solution. However, the reduction in system inertia due to increasing the amount of RERs causes undesirable impact to MG dynamic stability, threatens the system security, and could lead to complete blackouts as well as damages to the system equipment. Therefore, maintaining the dynamic security in MGs is one of the important challenges, which considered in this paper using a specific design of a digital over/under frequency relay (OUFR) with coordination of the VIC to protect the MG against high-frequency variations. To prove the effectiveness of the proposed coordination strategy, it has been tested considering sudden load change, high integration of RERs. Moreover, the sensitivity analysis of the presented technique was examined by varying the inertia level of MG system. The results stated that the proposed coordination can effectively regulate the MG frequency and maintain the dynamic stability and security.
A quasi-boundary regularization method for identifying the initial value of time-fractional diffusion equation on spherically symmetric domain
Authors: Yang Fan , Wang Ni , Li Xiao-Xiao , Huang Can-Yun
Published: January 2019

In this paper,
an inverse problem to identify the initial value for high dimension time fractional diffusion equation on spherically symmetric domain is considered. This problem is ill-posed in the sense of Hadamard, so the quasi-boundary regularization method is proposed to solve the problem. The convergence estimates between the regularization solution and the exact solution are presented under the a priori and a posteriori regularization parameter choice rules. Numerical examples are provided to show the effectiveness and stability of the proposed method.
On solenoidal-injective and injective ray transforms of tensor fields on surfaces
Authors: Krishnan Venkateswaran P. , Mishra Rohit K. , Monard François
Published: January 2019

We first give a constructive answer to the attenuated tensor tomography problem on simple surfaces. We then use this result to propose two approaches to produce vector-valued integral transforms, which are fully injective over tensor fields. The first approach is by construction of appropriate weights, which vary along the geodesic flow, generalizing the moment transforms. The second one is by changing the pairing with the tensor field to generate a collection of transverse ray transforms.
Identification of an unknown spatial load distribution in a vibrating beam or plate from the final state
Authors: Van Bockstal Karel
Published: January 2019

The theoretical and numerical determination of a space-dependent load distribution in
a simply supported non-homogeneous Euler–Bernoulli beam and Kirchhoff–Love plate is investigated. The uniqueness of a solution to this inverse source problem is proved, whilst counterexamples are constructed to discuss the conditions under which uniqueness holds.
A convergent and stable iterative algorithm is proposed for the recovery of the unknown load source and a stopping criterion is also given.
Several one-dimensional numerical experiments are considered to investigate the properties
of the proposed iterative procedure.
All-Optical Switching Device Using Plasmonic Mach-Zehnder Interferometer Structure
Authors: Singh Lokendra , Kumar Santosh , Kaushik Brajesh Kumar
Published: January 2019

The basic logic gates play a key role in performing the mathematical computation. The plasmonics has the uniqueness of confining surface plasmons beyond the diffraction limit. Plasmonic-based Mach-Zehnder interferometer with an extinction ratio of 26 dB is proposed to design the structure of all-optical XOR and XNOR logic gate. A theoretical analysis of proposed gate is carried out using finite-difference-time-domain method and MATLAB simulation results.
Evaluation of Gravity Data Derived from Global Gravity Field Models Using Terrestrial Gravity Data in Enugu State, Nigeria
Authors: Apeh O.I. , Moka E.C. , Uzodinma V.N.
Published: January 2019

Spherical harmonic expansion is a commonly applied mathematical representation of the earth’s gravity field. This representation is implied by the potential coeffcients determined by using elements/parameters of the field observed on the surface of the earth and/or in space outside the earth in the spherical harmonic expansion of the field. International Centre for Gravity Earth Models (ICGEM) publishes, from time to time, Global Gravity Field Models (GGMs) that have been developed. These GGMs need evaluation with terrestrial data of different locations to ascertain their accuracy for application in those locations. In this study, Bouguer gravity anomalies derived from a total of eleven (11) recent GGMs, using sixty sample points, were evaluated by means of Root-Mean-Square difference and correlation coeficient. The Root-Mean-Square differences of the computed Bouguer anomalies from ICGEMwebsite compared to their positionally corresponding terrestrial Bouguer anomalies range from 9.530mgal to 37.113mgal. Additionally, the correlation coe_cients of the structure of the signal of the terrestrial and GGM-derived Bouguer anomalies range from 0.480 to 0.879. It was observed that GECO derived Bouguer gravity anomalies have the best signal structure relationship with the terrestrial data than the other ten GGMs. We also discovered that EIGEN-6C4 and GECO derived Bouguer anomalies have enormous potential to be used as supplements to the terrestrial Bouguer anomalies for Enugu State, Nigeria.
An approach to the notion of “linguistic minority” in the light of the identificatory relation between a group and its minority language
Authors: Viaut Alain
Published: January 2019

The notion of “linguistic minority” not only incorporates the concept of group but also serves to define that group. Yet the relation between language and group can be considered in various ways. The primary function of language being that of communication, this will necessarily play a key role in defining the contours of any group whose language is different from neighbouring languages. Regardless of whether a group is established in a territory, for as long as it practises and asserts its language, the identificatory relation between that language and that group, and its consequences, implies different degrees of awareness.

Any linguistic minority draws on structures of its own which are perceived as its own. To be able to categorise it, will mean emphasising the identificatory relation between language and group. In contrast concepts such as “minority language” rely primarily upon the territorialised legitimacy of a language or upon its demolinguistic data. This link with the group can reinforce linguistic consciousness with the help of its own structures, support that “minority language” does not necessarily imply.
A wink and a nod: The role of emojis in forming digital communities
Authors: Graham Sage L.
Published: January 2019

As digital interactions become more global, individuals who bring divergent practices ‘to the keyboard’ must interact with other participants who come to the digital space with different cultural norms and expectations. This study explores the interface between local expectations and global practice through emoji use in online gaming – a venue which brings people from around the globe together on a common ‘playing field’. Since emojis were originally designed to tap into universals in human experience and expression, they are a ready-made resource through which individuals can integrate their culture-based expectations with communicative norms that are rooted in the common denominators of the (global) digital environment. Using live chat data from the game streaming platform Twitch, this study examines emojis posted to the open chat room during game streams of one female and one male gamer. The analysis examines the ways that participants use these semiotic images to orient toward gaming communities of practice and claim identities within gaming groups. It also explores whether emoji use is affected by the gender of the streamer. Analysis indicates that participants in the man’s stream differ from participants woman’s stream in the ways they use emojis to claim community membership and employ emojis as phatic devices.
Negotiating “thick” identities through “light” practices: YouTube metalinguistic comments about language in Ukraine
Authors: Tovares Alla V.
Published: January 2019

This article investigates YouTube metalinguistic comments about language varieties in Ukraine as a “light” practice to demonstrate how knowledge and identities are negotiated online against the backdrop of larger sociopolitical discourses that circulate in and about Ukraine. This work adds to our understanding of online, or “light”, identity construction by suggesting that taking up epistemic stances and overtly asserting epistemic statuses are often a part of such identity work. Furthermore, deliberate linguistic choices not only serve to index identities but also create (dis)affiliations and thus can be deployed as a means of inclusion or exclusion from a particular online group, often shifting between (and integrating) local and global themes and audiences. The analysis shows how by drawing on repetition, deixis, pronouns, and lexical choices, YouTube commenters police, reify, and contest the extant language practices and underlying ideologies and in so doing create a foundation for grassroots ideological and political mobilization.
“You might want to look up the definition of ‘continental breakfast’”: Other-initiated repair and community-building in health and weight loss blogs
Authors: Gordon Cynthia
Published: January 2019

This study examines other-initiated repair as what has been termed alight practice, demonstrating how it facilitates interactivity and moments of community creation online. Specifically, I analyze user comments on expert-written blogs that appear on an English-language weight loss website, showing how posters collaboratively initiate, accomplish, and show appreciation for repair activities. These activities, which are, as in face-to-face conversation, typically mitigated through various linguistic strategies, are aimed at aspects of blog text (including vocabulary and amount of information provided), as well as the choice of accompanying images. I show how various people – commenters, a person profiled in a blog, and bloggers – all may play roles in collaboratively accomplishing repair and thereby engage in the community. In addition, I suggest that repair not only facilitates participation, but also simultaneously serves as a means of highlighting shared expectations, or what have been calledcultural discourses, about expert-written blogs. In other words, in engaging in repair activities, participants create routine forms of interaction that also (re)affirm shared expectations among members of this community.
Method for predicting lignocellulose components in jute by transformed FT-NIR spectroscopic data and chemometrics
Authors: Uddin M. Nashir , Ahmed Sohan , Ray Swapan Kumer , Islam M. Saiful , Quadery Ariful Hai , Jahan M. Sarwar
Published: January 2019

In this investigation, a nondestructive technique has been developed for determining chemical composition of jute fiber by chemometric modeling with pretreated FT-NIR spectroscopic data. The chemical composition of jute fibers in wet chemical method were, 58 to 61.80 % α-cellulose, 13.0 to 21.90 % lignin, 9.89 to 16.8 % pentosan and 79.02 to 88.33 % holocellulose. FT-NIR spectral data from range 9000–4000 cm−1 of all jute samples were collected from the instrument. Spectral data of jute samples were pretreated with second order derivatives (SOD), standard normal variate (SNV) techniques and both together were used before calibration. Two chemometric calibration techniques: partial least square regression (PLSR) and artificial neural network (ANN) were assessed for predicting chemical compositions of Jute fibers. Result shows that prediction efficiency (

R

2

{\text{R}^{2}}

) of ANN varies from 72–99 % for calibration, validation and test datasets. However, by PLSR,

R

2

{\text{R}^{2}}

are much higher and consistent than those by earlier one. For α-cellulose, lignin, pentosan and holocellulose

R

2

{\text{R}^{2}}

values hover around 95–99 %. Thereby, a non-destructive, simple and cost effective novel method is being proposed to determine chemical compositions of jute with pretreated FT-NIR spectral data and chemometric calibration techniques.
Interaction of Lead and Nitrate on Growth Characteristics of Ornamental Judas Tree (Cercis siliquastrum L.)
Authors: Nejad Abdolhossein Rezaei , Hatamian Mansoure , Kafi Mohsen , Souri Mohammad Kazem , Shahbazi Karim
Published: January 2019

Lead is presently a significant heavy metal pollutant that is toxic for all types of life and is of worldwide concern. Various strategies may be applied to increase tolerance of plants to heavy metals, for example nitrogenous compounds have been shown to exert such effects. In the present study combinations of lead levels (0, 15, 30 mgL-1) and nitrate levels (0, 50, 100 mgL-1) applied through irrigation water, were evaluated for interactions affecting growth of ornamental Judas tree seedlings. The treatments were arranged in a randomized factorial design with four replications. The results showed that interactions between lead and nitrate levels on growth traits were not significant; however, the simple effects of lead and nitrate were significant on most morphological traits. The morphological traits of leaf SPAD (Soil and Plant Analysis Development) value, leaf area, new shoots growth and relative water content of leaf were reduced by application of lead (particularly at 30 mgL-1). Nevertheless, application of nitrate particularly at 100 mgL-1 significantly offset the reduced plant growth traits induced by high levels of lead. The results indicate that presence of nitrate can significantly improve plant growth under high lead toxicity.
Mitigating Commitment through Negation
Authors: Quintero María Jesús Pérez
Published: January 2019

The purpose of this paper is to show that the theory of Functional Discourse Grammar constitutes a powerful model to account for the complex phenomenon of Neg-Raising in a consistent and systematic way. Previous studies on Neg-Raising, the phenomenon involving the transfer of the negative from a complement clause to the matrix clause, have traditionally characterized it in terms of syntactic and, more extensively, semantic criteria. These studies have focused on the delimitation of the type of verbs involved in this construction, since Neg-Raising is only allowed by some complement taking verbs, all related to certain kinds of modality. However, despite having been studied extensively, Neg-Raising remains an unclear phenomenon in certain respects. Taking as a point of departure the classification of Complement Clauses resulting from the application of the three parameters (Entity Type, Presupposition and Factuality) proposed within Functional Discourse Grammar, it is possible to arrive at a consistent delimitation of the constructions exhibiting Neg-Raising. Furthermore, the Morphological Level allows accounting for Neg- Raising without resorting to any kind of movement rule. It is through the operation of Morphological Encoding that the negative comes to occupy its position in the matrix clause.
Temporal Chunking Makes Life’s Events More Memorable
Authors: McGatlin Kristen C. , Newberry Kimberly M. , Bailey Heather R.
Published: January 2019

Declines in episodic memory accompany both healthy aging and age-related diseases, such as dementia. Given that memory complaints are common in the aging population, a wealth of research has evaluated the underlying mechanisms of these declines and explored strategy interventions that could offset them. In the current paper, we describe a newer approach to improving memory: event segmentation training. Event segmentation is an encoding strategy in which individuals parse continuous activity into meaningful chunks. The ability to segment activity is associated with later memory for the events, but unfortunately, this segmentation ability declines with age. Importantly, interventions designed to improve event segmentation have resulted in memory improvements for both young and older adults. We will review these past experiments as well as some new event segmentation training work that uses older adults’ semantic knowledge to improve their segmentation and episodic memory. We believe that future research on event segmentation is a promising avenue for improving older adults’ ability to remember everyday activities.
Investigation of Carbonyl of Asphalt Binders Containing Antiaging Agents and Waste Cooking Oil Using FTIR Spectroscopy
Authors: Cong Peiliang , Hao Hongjie , Luo Weihua
Published: January 2019

The improved antiaging property of asphalt binders containing two types of antioxidants (tns-(2.4-di-tert-butyl)-phosphite (168) and antioxidant 1010 (1010)) and waste cooking oil (WCO) were investigated using Fourier transform infrared spectroscopy. In addition, the regeneration of WCO in aged asphalt binders was discussed. To assess the effects of antioxidants and WCO on the antiaging property of asphalt binders during the thermal oxidative aging process and the regeneration of WCO in aged asphalt binders, the carbonyl indexes were calculated. Experimental results indicated that 168, 1010, and WCO could reduce the carbonyl index of asphalt binders, and moreover, asphalt binders containing 168 had a smaller carbonyl index than those containing 1010, and the carbonyl indexes of the aged asphalt binders were reduced with the increase in WCO content. Therefore, the antioxidants and WCO could improve the antiaging property of asphalt binders, and WCO could be used as a rejuvenator for aged asphalt binders.
PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer
Authors: Wong Kristen , Di Cristofano Francesca , Ranieri Michela , De Martino Daniela , Di Cristofano Antonio
Published: January 2019

Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. Despite its low incidence, it accounts for a disproportionate number of thyroid cancer-related deaths, because of its resistance to current therapeutic approaches. Novel actionable targets are urgently needed to prolong patient survival and increase their quality of life. Loss and mutation of theRB1tumor suppressor are rare events in ATC, which suggests that therapies directed at inhibiting the cyclin D/CDK4complexes, responsible for RB phosphorylation and inactivation, might be effective in this tumor type. In fact, we found that the CDK4/6 inhibitor, palbociclib, strongly inhibits proliferation in all theRB1wild-type ATC cell lines tested. Efficacy was also observedin vivo, in a xenograft model. However, ATC cells rapidly developed resistance to palbociclib. Resistance was associated with increased levels of cyclin D1 and D3. To counter cyclin D overexpression, we tested the effect of combining palbociclib with the PI3K/mTOR dual inhibitor, omipalisib. Combined treatment synergistically reduced cell proliferation, even in cell lines that do not carry PI3K-activating mutations. More importantly, low-dose combination was dramatically effective in inhibiting tumor growth in a xenograft model. Thus, combined PI3K/mTOR and CDK4/6 inhibition is a highly promising novel approach for the treatment of aggressive, therapy-resistant thyroid cancer.
Some aspects of leadership in the neo-Hindu religious movement: The case of the Art of Living Foundation in Lithuania
Authors: Ališauskienė Milda
Published: January 2019

Vilnius UniversityThe leader in any new religious group is a very important person and a key feature in the establishment of the organized religion. The special role and place for the leader is found in the so-called spiritual groups—the Neo-Hindu religious movements. Although such groups do not relate themselves to any religious phenomena in general, an analysis of their activities reveals the traditional importance of their leader in doctrinal and organizational development. The aim of this article is to analyze the role and place of Ravi Shankar, the leader of the Art of Living Foundation (AoLF), the process of his charismatization, as well as the attitudes of members toward the leader and his legitimization from the perspective of the sociology of religion. The work is based on the analysis of certain official documents of the organization and through narratives of members from Lithuania and Denmark. The article focuses on the case of Lithuania, which is revealed through the comparison of the data from Denmark. The analysis revealed that individuals expressed special attitudes toward the leader of the group: that, on the one hand, modern individuals sought liberation from institutionalized religion but at the same time they were searching for spiritual authority. Interviews with members of the AoLF revealed diverse concepts of the spiritual leader. Contrary to the traditionally accepted understanding of a spiritual leader as the head of authority, the narratives revealed an understanding of the spiritual leader as both an advisor and a service provider.
Archeologijos katedros mokslinės veiklos apžvalga
Authors: Vasiliauskienė Violeta
Published: January 2019

...
Wojciechui Nowakowskiui – 65-eri
Authors: Michelbertas Mykolas
Published: January 2019

...
XVI–XVIII amžiaus artilerijos pabūklai, saugomi Lietuvos muziejuose ir privačioje kolekcijoje
Authors: Vasiliauskas Liudvikas
Published: January 2019

This article discusses all the original 16th–18th c. artillery guns kept and displayed in Lithuanian museums and a private collection. The guns have been grouped in accordance with their types, dates of manufacture and their storage/display locations. There are also data provided by the X-ray fluorescence (XRF) analyses of gun barrel alloys’ chemical elements. The text is supplemented by a catalogue of the abovementioned artillery guns.

Keywords: artillery, kartouwe, culverin, bombard, howitzer, mortar, swivel cannon, field cannons
XVII–XIX amžiaus archeologiniai odos radiniai iš Žiežmarių
Authors: Puškorius Arūnas , Žvirblys Atas
Published: January 2019

The article investigates archaeological leather finds that were unearthed in Žiežmariai during archaeological excavations in years 2013 and 2015. A variety of finds is revealed; the constructions of items and the peculiarities of producing have been analyzed. These kinds of artifacts are rare in the archaeological stretches of the Lithuanian periphery towns. Their analysis lead us to a better understanding of the specific features of the daily life of periphery towns, which are situated in distant locations from the economic and political centers.

Keywords: leather shoes, archaeological excavations, periphery, Žiežmariai, leather artifacts
Vėlyvojo žalvario ir ankstyvojo geležies amžiaus laidosena ir visuomenė Šiaurės vakarų Lietuvoje
Authors: Muradian Lijana
Published: January 2019

This article investigates the burial customs of the Late Bronze and Early Iron Ages in the territory of northwest Lithuania, focusing on barrow mounds and individual grave settings and grave goods. More than a century of excavations yielded 19 burial sites, in which 182 graves are known (169 cremations and 13 inhumations). The gathered data regarding burial customs consist of grave settings, burial locations within the mounds and grave goods, and these are used to interpret some features of how the communities were socially organized. During the Late Bronze and Early Iron Ages, the dead were buried in different types of graves: barrow mounds and flat graves; individual graves had different stone arrangements in both of mentioned types. This work presents a hypothesis that different types of graves and stone arrangements associated with burials were not just a result of time-related burial customs changes, but it could be an indicator of the social identity of the deceased. It is one of the possible indicators that hierarchic societies existed during the period in question.

Keywords: Late Bronze Age, Early Iron Age, barrow mounds, cremation burials, inhumation burials, society, northwest Lithuania
Žvilgsnis į Lietuvos archeologijos paveldo apsaugos ištakas
Authors: Kuncevičius Albinas , Poškienė Justina
Published: January 2019

The processes of legislation and the development of systems for the preservation of ancient remains, including archaeological heritage, were under development in the countries of Western Europe during the 19th century. The paper seeks to observe the ideas and practices of heritage preservation in Lithuania under the Russian Empire – it is intended to reveal the circumstances under which the notion of heritage protection was born and the ways of its practical implementation. The origins of archaeological science and heritage protection in Lithuania can be traced to the beginning of the 19th c. By the middle of the century, elements of professional heritage protection were implemented in the activities of the Vilnius Museum of Antiquities and the Vilnius Temporary Archaeological Commission. Certain components of professional heritage protection were established in the end of the 19th c.; nevertheless, attempts to pass the general law and to introduce the system of archaeological heritage protection in the Russian Empire were not successful. The birth of a modern Lithuanian nation demanded relevant approaches toward its past in late 19th–early 20th centuries. Efforts were put into the development of the modern Lithuanian national state thus delaying the development of a professional heritage protection system.

Keywords: archaeology, science, heritage protection, history of archaeology
Paraná’s Credit Unions: an analysis of their efficiency and productivity change
Authors: Martins Luis Guilherme Ribeiro , Steiner Maria Teresinha Arns , Wilhelm Volmir Eugênio , Steiner Neto Pedro José , Dos Santos Bruno Samways
Published: January 2019

The aim of this paper is to evaluate the efficiency and productivity change of Paraná’s Credit Union. The analysis considered 45 units (each credit union researched), each of one with 10 variables in each period (8 inputs and 2 outputs). This evaluation has taken into account quarterly credit union’s data, from January 2009 to July 2015 (27 periods). The methodology included Data Envelopment Analysis (DEA), Principal Components Analysis (PCA) and Malmquist Index (MI) techniques. The results showed that DMUs 453, 498 and 517 were considered 100% efficient in all periods, making them ideal benchmarks. There was no case that a DMU was not considered 100% efficient in at least one observation. The MI showed that the difference between the biggest and the smallest average was significant (varying between 19.837 for DMU 251 and 0.926 for DMU 450). The average between all MI was 4,735 with a standard deviation of 3,547, evidencing the different measures of efficiency between each DMU when compared to the others.
External strengthening of unreinforced masonry walls with polymers reinforced with carbon fiber
Authors: Vega Camilo , Torres Nancy
Published: January 2019

In many countries, buildings are usually made of unreinforced clay masonry walls, especially in Colombia. These constructions have low resistance and ductility, and are very vulnerable to seismic events, due to their low capacity of energy dissipation. This paper reports the results obtained from a research project that evaluates the behavior of reinforced masonry walls under lateral loads. The reinforcement was made using Carbon Fiber Reinforced Polymers (CFRP). In the test program, eight (8) clay masonry walls were built using hollow brick. Four (4) of them were 1,23 m long and 1,90 m high and the remaining four (4) were 2,47 m long and 1,90 m high. Four (4) walls were tested with a static lateral load and four (4) with a cyclic lateral load in its plane. Results revealed that the presence of the reinforcement material significantly increased the ultimate load and deformation capacity, provided that the material has a suitable anchoring system.
Minimising Total Flowtime in a No-Wait Flow Shop (NWFS) using Genetic Algorithms
Authors: Chaudhry Imran Ali , Elbadawi Isam AbdulQader , Usman Muhammad , Chughtai Muhammad Tajammal
Published: January 2019

This paper considers a no-wait flow shop scheduling (NWFS) problem, where the objective is to minimise the total flowtime. We propose a genetic algorithm (GA) that is implemented in a spreadsheet environment. The GA functions as an add-in in the spreadsheet. It is demonstrated that with proposed approach any criteria can be optimised without modifying the GA routine or spreadsheet model. Furthermore, the proposed method for solving this class of problem is general purpose, as it can be easily customised by adding or removing jobs and machines. Several benchmark problems already published in the literature are used to demonstrate the problem-solving capability of the proposed approach. Benchmark problems set ranges from small (7-jobs, 7 machines) to large (100-jobs, 10-machines). The performance of the GA is compared with different meta-heuristic techniques used in earlier literature. Experimental analysis demonstrate that solutions obtained in this research offer equal quality as compared to algorithms already developed for NWFS problems.
Identifikasi Senyawa Flavonoid dari Daun Kembang Bulan (Tithonia Diversifolia) dengan Metode Pereaksi Geser
Authors: Zirconia Aisyah , Kurniasih Nunung , Amalia Vina
Published: January 2019

ABSTRAKIndonesia adalah salah satu negara yang kaya akan jenis flora yang berkhasiat sebagai tanaman obat. Salah satunya yaitu kembang bulan (Tithonia diversifolia). Dari uji yang pernah dilakukan, tanaman ini mengandung senyawa flavonoid yang berguna sebagai anti bakteri dan anti diabetes. Dalam penelitian ini akan ditentukan jenis eluen terbaik untuk mengisolasi senyawa flavonoid dan jenis senyawa flavonoid yang terdapat dalam ekstrak daun kembang bulan. Ekstraksi senyawa flavonoid dari daun kembang bulan dilakukan dengan cara maserasi menggunakan pelarut aseton : air (7:3) selama 5x24 jam, kemudian dilakukan fraksinasi menggunakan pelarut n-heksana dan etil asetat. Setelah itu, dilakukan uji fitokimia senyawa flavonoid menggunakan uji Wilstatter, Bate-Smith dan NaOH 10%. Pemisahan senyawa flavonoid dari ekstrak dilakukan dengan kromatografi lapis tipis (KLT) untuk mencari eluen terbaik dengan variasi eluen yaitu n-heksana : etil asetat (8:2), asam asetat : H2O : HCl pekat (30:10:3), n-butanol : asam asetat : air (4:1:5), dan metanol : etil asetat (4:1), kemudian dilanjutkan dengan isolasi senyawa flavonoid. Identifikasi senyawa flavonoid dilakukan dengan metode pereaksi geser dan FTIR. Hasil penelitian menunjukkan bahwa dari uji fitokimia dari ketiga reagen menunjukkan positif mengandung senyawa flavonoid. Eluen terbaik dalam pemisahan senyawa flavonoid dengan KLT adalah n-heksana : etil asetat (8:2) yang dapat digunakan dalam mengisolasi senyawa flavonoid. Eluen ini memisahkan 3 noda dengan warna jingga. Berdasarkan hasil analisis spektrofotometer UV-Vis (metode pereaksi geser), menunjukkan bahwa isolat adalah golongan flavonol. Hasil identifikasi dengan FTIR menunjukkan serapan-serapan yang spesifik dari senyawa flavonoid seperti rentangan asimetri OH pada bilangan gelombang 3443,9 cm-1, rentangan cincin aromatik pada 11367,9 cm-1, pita serapan kuat karbonil pada angka 1648,3 cm-1 dan golongan eter yang diperkuat oleh puncak serapan 1060,3 cm-1 sehingga senyawa flavonoid yang diduga adalah 5,7,8,3’,4’-pentahidroksiflavonol atau 5,6,7,3’,4’-pentahidroksiflavonol.
Pemanfaatan Biji Asam Jawa (Tamarindus indica) sebagai Koagulan Alami dalam Pengolahan Limbah Cair Industri Farmasi
Authors: Poerwanto Dyah Dwi , Hadisantoso Eko Prabowo , Isnaini Soehartini
Published: January 2019

ABSTRAKTelah dilakukan penelitian pemanfaatan biji asam jawa dalam pengolahan limbag cair industri farmasi dengan metoda koagulasi. Koagulasi dan flokulasi merupakan metode pengolahan air untuk limbah yang bersifat koloid. Biji asam jawa mengandung tanin sebesar 20,2 % yang bersifat sebagai koagulan dan polimer alami seperti pati sebesar 30,1 % yang berfungsi sebagai flokulan. Penelitian ini diawali dengan preparasi koagulan dimana biji asam jawa yang telah dibersihkan ditumbuk hingga menjadi serbuk lalu diayak dengan ayakan tepung. Selanjutnya sampel air limbah ditambahkan koagulan dengan variasi dosis yaitu 1, 3, 5, 7, 9, dan 11 gram/500 mL sampel air limbah, lalu diaduk dengan kecepatan cepat 3 menit dan kecepatan lambat 12 menit, kemudian diendapkan 12 menit. Filtrat hasil koagulasi dianalisis berdasarkan Kep-51/MENLH/10/1995 tentang baku mutu limbah cair industri farmasi. Dari hasil penelitian ini diketahui bahwa kemampuan biji asam jawa cukup baik sebagai koagulan untuk memperbaiki nilai pH, menurunkan konsentrasi TSS pada dosis optimum 1 g/500 mL, BOD pada dosis optimum 7 g/500mL, serta NH4+ pada dosis optimum 3 g/500 mL. Namun, koagulan ini belum dapat digunakan untuk menurunkan konsentrasi COD dan fenol dalam limbah cair industri farmasi.
Sintesis Cu(II)-Imprinted Polymers untuk Ekstraksi Fasa Padat dan Prakonsentrasi Ion Cu(II) dengan Ligan Pengkhelat 4-(2-Pyridylazo)resorcinol
Authors: Harera Lingga Rizal , Sudiarti Tety , Wulandari Meyliana
Published: January 2019

ABSTRAKKontaminasi logam berat pada lingkungan perairan merupakan masalah besar dunia saat ini. Logam berat tidak dapat diurai atau dimusnahkan dan merupakan zat pencemar kimiawi. Cu(II) adalah logam berat yang bersifat racun jika masuk kedalam tubuh. Metode analisis Cu(II) sudah banyak dikembangkan salah satunya dengan teknik injeksi alir. Metode analisis ini memiliki waktu analisis yang singkat namun menggunakan pelarut yang mahal, faktor prakonsentrasi yang rendah, dan memiliki selektivitas yang rendah pula untuk ion Cu(II). Oleh karena itu, untuk meningkatkan selektivitas dilakukan pengembangan metode ekstraksi fasa padat menggunakan polimer pengkelat yaitu Ion Imprinted polymer (IIPs). Pada penelitian ini, Cu-IP berhasil disintesis melalui polimerisasi thermal menggunakan asam salisilat dan formaldehida dengan ligan pengkelat 4-(2-pyridylazo)recorcinol dengan pemanasan selama 10 jam pada temperatur 500C , menggunakan HCl sebagai katalis. Perbandingan stoikiometri kompleks biner Cu(II):PAR dibuat dengan perbandingan mol 1:1 yang dihitung dengan metode job. Kapasitas adsorpsi maksimum teramati pada konsentrasi 10 ppm dengan pH 6 dan waktu kontak 80 menit. IIP digunakan untuk prakonsentrasi adsorpsi dan desorpsi dengan persen perolehan kembali sebesar 97,09 % untuk IIP dan 53,11 % untuk NIP. Faktor prakonsentrasi yang diperoleh pada sampel lingkungan sebesar 1,85. Dengan hasil percobaan tersebut Cu-IP terbukti sebagai polymer fungsional dengan selektivitas dan regenerasi tinggi.
Studi Komputasi Senyawa Berbasis Anisil Indol dengan Senyawa Akseptor Asam Sianoakrilik sebagai Sensitizer Solar Sel Organik
Authors: Setiadji Soni , Ivansyah Athar Luqman , Pribadi Adi Bungsu
Published: January 2019

ABSTRAKPenelitian ini memprediksi sifat elektronik (diagram energi HOMO/LUMO, spektrum UV-Vis, dan rapatan orbital HOMO/LUMO) dari senyawa zat warna organik anisil indol / bi-3-n-heksiltiopen / asam sianoakrilik dan anisil indol / bi-3-n-heksiltiopen / katekol. Perhitungan komputasi dari ke dua senyawa tersebut[1], yang memodelkan sistem senyawa donor elektron / senyawa penghubung / senyawa penarik/akseptor elektron, dilakukan untuk membandingkan sifat elektronik ke dua senyawa penarik elektron tersebut agar dapat dipakai sebagai sensitizer dalam sel surya organik / sel surya tersensitasi zat warna. Dye Sensitized Solar Cell (DSSC) merupakan salah satu generasi sel surya yang banyak diteliti sampai saat ini. Sel surya ini menggunakan zat warna sebagai sensitizer dan menjadi sangat menarik untuk dikembangkan karena membutuhkan biaya produksi yang murah namum mampu menghasilkan kinerja yang cukup baik. Dalam penelitian ini perhitungan komputasi dilakukan menggunakan perangkat lunak Firefly, metoda DFT (teori fungsi rapatan) dan TDDFT (teori fungsi rapatan fungsi waktu), B3LYP/6-31G(d,p) untuk semua atom. Spektrum UV-Vis senyawa anisil indol / bi-3-n-heksiltiopen / asam sianoakrilik hasil perhitungan komputasi memberikan serapan cahaya pada panjang gelombang 493,75 nm dengan kekuatan osilator 0,918. Sedangkan senyawa anisil indol / bi-3-n-heksiltiopen / katekol memberikan serapan cahaya pada panjang gelombang lebih pendek yaitu 410,53 nm dengan kekuatan osilator 1,4658. Diagram energi HOMO/LUMO untuk anisil indol / bi-3-n-heksiltiopen / asam sianoakrilik dan anisil indol / bi-3-n-heksiltiopen / katekol memberikan band gap masing-masing sebesar 2,75 eV dan 3,33 eV. Berdasarkan perhitungan energi, sistem zat warna dengan senyawa akseptor asam sianoakrilik memiliki energi yang lebih stabil dibandingkan dengan senyawa akseptor katekol.