bluuebunny/crossref_metadata_2025 huggingface dataset:
AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy
Authors: Yin Yichun , Wang Jian , Yi Junxuan , Zhang Kaiyue , Yin Zimeng , Jin Shunzi , Zheng Baisong
Published: January 2024

Background:

Radiation (IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment (TME). Wee1, a cell cycle regulator, can eliminate G2/M arrest by phosphorylating cyclin-dependent kinase 1 (CDK1). Meanwhile, programed death-1/programed death ligand-1 (PD-1/PDL-1) blockade is closely related to TME. This study aims to investigate the effects and mechanisms of Wee1 inhibitor AZD1775 and anti-PD-1 antibody (anti-PD-1 Ab) on radiosensitization of hepatoma.

Methods:

The anti-tumor activity of AZD1775 and IR was determined by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) assay on human and mouse hepatoma cells HepG2, Hepa1-6, and H22. The anti-hepatoma mechanism of AZD1775 and IR revealed by flow cytometry and Western blot in vitro. A hepatoma subcutaneous xenograft mice model was constructed on Balb/c mice, which were divided into control group, IR group, AZD1775 group, IR + AZD1775 group, IR + anti-PD-1 Ab group, and the IR + AZD1775 + anti-PD-1 Ab group. Cytotoxic CD8+ T cells in TME were analyzed by flow cytometry.

Results:

Combining IR with AZD1775 synergistically reduced the viability of hepatoma cells in vitro. AZD1775 exhibited antitumor effects by decreasing CDK1 phosphorylation to reverse the IR-induced G2/M arrest and increasing IR-induced DNA damage. AZD1775 treatment also reduced the proportion of PD-1+/CD8+ T cells in the spleen of hepatoma subcutaneous xenograft mice. Further studies revealed that AZD1775 and anti-PD-1 Ab could enhance the radiosensitivity of hepatoma by enhancing the levels of interferon γ (IFNγ)+ or Ki67+ CD8 T cells and decreasing the levels of CD8+ Tregs cells in the tumor and spleen of the hepatoma mice model, indicating that the improvement of TME was manifested by increasing the cytotoxic factor IFNγ expression, enhancing CD8+ T cells proliferation, and weakening CD8+ T cells depletion.

Conclusions:

This work suggests that AZD1775 and anti-PD-1 Ab synergistically sensitize hepatoma to radiotherapy by enhancing IR-induced DNA damage and improving cytotoxic CD8+ T cells in TME.
Targeting HIV persistence in the tissue
Authors: Pieren Daan K.J. , Benítez-Martínez Aleix , Genescà Meritxell
Published: January 2024

Purpose of review

The complex nature and distribution of the HIV reservoir in tissue of people with HIV remains one of the major obstacles to achieve the elimination of HIV persistence. Challenges include the tissue-specific states of latency and viral persistence, which translates into high levels of reservoir heterogeneity. Moreover, the best strategies to reach and eliminate these reservoirs may differ based on the intrinsic characteristics of the cellular and anatomical reservoir to reach.

Recent findings

While major focus has been undertaken for lymphoid tissues and follicular T helper cells, evidence of viral persistence in HIV and non-HIV antigen-specific CD4+ T cells and macrophages resident in multiple tissues providing long-term protection presents new challenges in the quest for an HIV cure. Considering the microenvironments where these cellular reservoirs persist opens new venues for the delivery of drugs and immunotherapies to target these niches. New tools, such as single-cell RNA sequencing, CRISPR screenings, mRNA technology or tissue organoids are quickly developing and providing detailed information about the complex nature of the tissue reservoirs.

Targeting persistence in tissue reservoirs represents a complex but essential step towards achieving HIV cure. Combinatorial strategies, particularly during the early phases of infection to impact initial reservoirs, capable of reaching and reactivating multiple long-lived reservoirs in the body may lead the path.
Mosaic Muir Torre Syndrome: Keratoacanthoma as a Piece of the Puzzle
Authors: O'Brien Amber , Macfarlane Sarah , Sommerlad Matthew , Schirwani Schaida
Published: January 2024

Lynch syndrome is an inherited condition, which increases the risk of numerous visceral malignancies and cutaneous tumors such as keratoacanthomas and sebaceous tumors. It is typically identified by immunohistochemistry of tissue taken from tumors or through genetic testing with next-generation sequencing. Diagnosing Lynch syndrome becomes more complex when the individual is mosaic for the relevant pathogenic variant. There are very few cases of this reported in the medical literature. It is even more unusual for the diagnosis to be made based on testing of a keratoacanthoma lesion. We report a case where immunohistochemistry of a keratoacanthoma helped make a diagnosis of mosaic Lynch syndrome. We will explore how mosaicism should be considered when a phenotype is strong, even if next-generation sequencing reports no pathogenic or likely pathogenic variant and how lesions such as keratoacanthomas can have a role in the early detection and treatment of future malignancies.
Evaluating tranexamic acid for the prevention and treatment of obstetric hemorrhage
Authors: Kowalczyk John J. , Cecconi Maurizio , Butwick Alexander J.
Published: January 2024

Purpose of review

Tranexamic acid (TXA) has emerged as a promising pharmacological adjunct to treat and prevent postpartum hemorrhage (PPH). We provide an overview of TXA, including its pharmacology, key findings of randomized trials and observational studies, and critical patient safety information.

Recent findings

Pharmacokinetic data indicate that TXA infusions result in peak plasma concentration within 3 min (range: 1–6.6 min). Ex-vivo pharmacodynamic data suggest that low-dose TXA (5 mg/kg) inhibits maximum lysis for at least 1 h. In predominantly developing countries, TXA has demonstrated a 19% reduction in the risk of bleeding-related death among patients with PPH. Based on high-quality randomized trials, TXA prophylaxis does not effectively reduce the risk of PPH during vaginal delivery and is likely ineffective in reducing the PPH risk during cesarean delivery. TXA exposure does not increase the risk of maternal thrombotic events. Maternal deaths have occurred from accidental intrathecal TXA injection from look-alike medication errors.

TXA has shown promise as an important adjunct for PPH treatment, especially in low-resource settings. However, TXA is not recommended as PPH prophylaxis during vaginal or cesarean delivery. Patient safety initiatives should be prioritized to prevent maternal death from accidental intrathecal TXA injection.
Provider Perceived Facilitators and Barriers to Identifying, Perceiving, and Seeking Healthcare for Chronic Pain After TBI: A Qualitative NIDILRR and VA TBI Model Systems Collaborative Project
Authors: Nakase-Richardson Risa , Cotner Bridget A. , Agtarap Stephanie D. , Martin Aaron M. , Ching Deveney , O'Connor Danielle R. , Tweed Amanda , Haun Jolie N. , Hanks Robin A. , Bergquist Thomas F. , Hammond Flora M. , Zafonte Ross D. , Hoffman Jeanne M.
Published: January 2024

Objective:

Identify determinants to chronic pain healthcare for persons with traumatic brain injury (TBI) informed by an Access to Care Framework. Findings related to the Access Framework's core domains of identifying a need, perceptions of the need, and seeking healthcare are reported.

Setting:

Community.

Participants:

Healthcare providers (n = 63) with 2 or more years of experience treating persons with TBI interviewed between October 2020 and November 2021.

Design:

Descriptive, qualitative study.

Main Measures:

Semi-structured interviews with open-ended questions of chronic pain management for persons with TBI. Informed by the Access Framework, responses were coded by and categorized within the domains of identifying healthcare needs, perceptions of needs, and factors related to healthcare seeking from the supply and demand perspective.

Results:

For the overall sample, 14 facilitators and 6 barriers were endorsed by more than 20% of the provider cohort. Top facilitators included on-site availability of needed resources and treatments (94%), adequate time and provider capability to ensure patient comprehension of diagnosis and treatment plans (83%), and establishing patient motivation and buy-in with the treatment plan (75%). Barriers most endorsed included policies impacting access (46%), wait times for services (41%), and patient uncertainty regarding telehealth commonly due to cognitive and physical challenges (37%). Unique determinants are reported across civilian versus Department of Veterans Affairs (VA) healthcare systems and different provider types.

Conclusion:

This is the first evidence-based study to inform policy and planning to improve access to high-quality chronic pain treatments for persons with TBI. Results will inform future interventions at the systems, patient, and policy levels of healthcare that can be tailored to healthcare settings (VA, Civilian) and types of providers (rehabilitation therapists, psychologists, and medical). Evidence-informed interventions may help minimize healthcare disparities experienced by persons with TBI and facilitate access to high-quality, evidence-informed chronic pain care.
The Interaction of Opiate Misuse and Marijuana Use on Behavioral Health Outcomes Using the Traumatic Brain Injury Model Systems Pain Collaborative Dataset
Authors: Callender Librada , Lai Tony , Driver Simon , Ketchum Jessica M. , Ochoa Christa , Corrigan John D. , Hammond Flora M. , Harrison-Felix Cindy , Martin Aaron M. , Rabinowitz Amanda R. , Starosta Amy J. , Dubiel Randi
Published: January 2024

Objective:

To determine if the interaction of opiate misuse and marijuana use frequency is associated with behavioral health outcomes.

Setting:

Community.

Participants:

Three thousand seven hundred fifty participants enrolled in the Traumatic Brain Injury Model Systems who completed the Pain Survey and had complete opioid use and marijuana use information.

Design:

Cross-sectional, secondary analysis from a multisite observational cohort.

Main Outcome Measure(s):

Clinically significant behavioral health symptoms for posttraumatic stress disorder (PTSD), depression, anxiety, and sleep quality.

Results:

Three thousand five hundred thirty-five (94.3%) participants did not misuse opiates, 215 (5.7%) did misuse opiates (taking more opioid pain medication than prescribed and/or using nonprescription opioid pain medication); 2683 (70.5%) participants did not use marijuana, 353 (9.3%) occasionally used marijuana (less than once a week), and 714 (18.8%) regularly used marijuana (once a week or more frequently). There was a statistically significant relationship (P< .05) between the interaction of opiate misuse and marijuana use frequency and all behavioral health outcomes and several covariates (age, sex, cause of injury, severity of injury, and pain group category). Pairwise comparisons confirm that statistically significant associations on behavioral health outcomes are driven by endorsing opiate misuse and/or regular marijuana use, but occasional marijuana use was not associated.

Conclusions:

Higher odds of clinically significant PTSD, depression, anxiety, and poor sleep quality are present in people with traumatic brain injury (TBI) who misuse opiates and/or who use marijuana regularly. In the absence of opiate misuse, regular marijuana use had higher odds of worse behavioral health outcomes than occasional and no use. The interaction of opiate misuse and regular marijuana use yielded the highest odds. Individuals with TBI should be informed of the relationship of substance use and behavioral health outcomes and that current chronic pain may mediate the association.
Professional Employment in Patients on Ventricular Assist Device Support—A National Multicenter Survey Study
Authors: Kugler Christiane , Spielmann Hannah , Albert Wolfgang , Lauenroth Volker , Spitz-Koeberich Christine , Semmig-Koenze Sandra , Staus Paulina , Tigges-Limmer Katharina ,   for the SELMA Study Group
Published: January 2024

This study aimed to assess patients of working age returning to professional employment as a surrogate marker for functional recovery and psychosocial reintegration after ventricular assist device (VAD) implantation. A national, multicenter study considered professional employment and its relationship to sociodemographic, psychosocial, and clinical adverse outcomes in outpatients on VAD support. Patient-reported outcome measures were administered. The survey had a 72.7% response rate. Mean age of 375 subjects was 58 ± 11 years, 53 (14%) were female. Thirty-five patients (15.15%; 95% confidence interval [CI] = 10.9–20.6) were employed, and the majority of them (n = 29, 82.9%) were bridged to transplantation. A regression model after variable selection revealed younger age (odds ratio [OR] = 0.95; 95% CI = 0.91–0.98; p < 0.005), and higher education (OR = 3.05; 95% CI = 1.72–5.41; p < 0.001) associated with professional employment. Employed patients reported higher health-related quality of life (HRQoL) (Kansas City Cardiomyopathy Questionnaire [KCCQ] overall sum-score, OR = 1.04; 95% CI = 0.92–1.07; p < 0.007), the OR for those employed was 2.18 (95% CI = 0.89–5.41; p < 0.08) indicating no significant relation for employment and a history of adverse events. In this sample, professional employment was rather small; the likelihood of adverse events was not significantly different between groups. Those employed perceived better overall HRQoL, which may encourage clinicians to support professional employment for selected patients on VAD support.
Community-acquired bacterial pneumonia in children: an update on antibiotic duration and immunization strategies
Authors: Lyon Edward , Olarte Liset
Published: January 2024

Purpose of review

This review is structured to update clinicians on the epidemiology, antibiotic treatment, and prevention of pediatric bacterial pneumonia. The review provides information regarding the current research on antibiotic management for bacterial pneumonia and the newest immunization recommendations to prevent pneumococcal pneumonia and other respiratory infections.

Recent findings

The recommended length of antibiotic therapy for bacterial pneumonia has been discrepant between low-income and high-income countries. Recently, randomized controlled trials conducted in high-income countries provided evidence to support a short antibiotic course (3–5 days) for uncomplicated bacterial pneumonia in otherwise healthy children. The negative impact of inaccurate penicillin allergy labels in children with pneumonia has emphasized the importance of prompt allergy de-labeling. Newer pneumococcal vaccines are recommended for children and are expected to have a significant impact on bacterial pneumonia rates.

Pediatric bacterial pneumonia is an important contributor to childhood morbidity and mortality. A short antibiotic course seems to be sufficient for the outpatient management of uncomplicated bacterial pneumonia; however, more studies are required in the inpatient setting. Future studies will inform the impact of recently introduced pneumococcal and respiratory syncytial virus vaccines on the epidemiology of bacterial pneumonia.
What is in the pipeline for new treatments for bladder pain syndrome/ interstitial cystitis?
Authors: Dias Diogo , Mendes Pedro Abreu , Oliveira Paulo Dinis , Pinto Rui Almeida
Published: January 2024

Purpose of review

Despite available treatments, many bladder pain syndrome/interstitial cystitis (BPS/IC) patients continue to have poor quality of life. Thus, there is an urge for new therapies. Our manuscript aims to review papers about BPS/IC treatments published in the last 2 years.

Recent findings

During this period, several treatments were tested, most of them new and others combining treatments already used. Pentosan polysulfate, interleukin 1 antagonist, low energy shock wave, physical therapy, hypnosis, acupuncture, clorpactin, dimethyl sulfoxide and hyaluronic acid plus botulinum toxin-A showed positive results. ASP3652 and lidocaine-releasing intravesical systems failed to prove their efficacy.

Validation of these studies is arduous due to the broad spectre of BPS/IC phenotypes, small number of patients enrolled, distinct outcome measures and short-term follow-up. It is also important to highlight that some authors combined therapies, and others split central and peripheric phenotypes before treatment. Therefore, soon, phenotyping and combining therapies with a step-by-step approach will be needed in BPS/IC treatment.
Retroperitoneal Castleman’s disease in a young Nepalese girl: A rare cause of childhood abdominal mass
Authors: Shrestha Ashish Lal , Mishra Aakash , Khadka Sagar , Dhakhwa Ramesh
Published: January 2024

Introduction:

Castleman’s disease (CD), or benign angio-follicular lymph node hyperplasia, is an uncommon condition in childhood. When a child presents with a huge retroperitoneal mass and inconclusive findings on clinico-radiological evaluation or tissue sampling, management becomes exceedingly difficult. CD herein becomes an uncommon presentation of an uncommon diagnosis.

Case presentation:

A six-year-old girl with no past medical problems presented to the office with a slowly progressive, painless mass over the right lumbar region for a year. Abdominal ultrasound showed a well-defined oval mass in the right periumbilical region, further evaluation of which with a computed tomography scan suggested lymphoma. A preoperative core-cut biopsy could not confirm the findings and suggested a neoplastic lesion, probably an inflammatory myofibroblastic tumour or small round cell tumour. She underwent an exploratory laparotomy with in-toto excision of the mass. Intraoperatively, a solid retroperitoneal tumour measuring 8×8×6 cm was found. Histopathology and immunohistochemistry confirmed a unicentric CD of the hyaline-vascular type. At two years of follow-up, she remained asymptomatic and disease-free.

Conclusion:

While CD in children is rare, retroperitoneal localization of the same can further add to the diagnostic conundrum. However, if carefully considered, an en-bloc surgical resection offers complete treatment.
Takayasu arteritis presenting as a stroke in young: a case report
Authors: Oli Paras , Poudel Prabhat , KC Shradha , Thapa Neeraj , KC Aastha
Published: January 2024

Introduction:

Takayasu arteritis is a large-vessel vasculitis predominantly seen in young women. Lack of signs and symptoms in the early stage of the disease often delays the diagnosis and thus leads to significant morbidity and mortality. One severe complication that may arise is a significant narrowing of blood vessels, potentially leading to life-threatening ischemic repercussions.

Case presentation:

The authors present a case of a 29-year-old female who presented to our ER with features of left-sided hemiparesis and right-sided facial deviation. Computed tomography angiography and Carotid Doppler helped in making the diagnosis of Takayasu arteritis. She was managed with prednisolone and mycophenolate mofetil. She has been on a regular follow-up for the last year and is currently stable.

Conclusion:

Even being a rare scenario, stroke can be the initial presentation of Takayasu arteritis. Early diagnosis and management in young patients are vital in keeping the disease at bay and preventing physical, mental, and socio-economic adversities.
Management of recurrent lumbar disc herniation: a comparative analysis of posterior lumbar interbody fusion and repeat discectomy
Authors: Musa Gerald , Makirov Serik K. , Chmutin Gennady E. , Susin Sergey V. , Kim Alexander V. , Antonov Gennady I. , Otarov Olzhas , Ndandja Dimitri T.K. , Egor G Chmutin , Chaurasia Bipin
Published: January 2024

Background:

For recurrent lumbar disc herniation, many experts suggest a repeat discectomy without stabilization due to its minimal tissue manipulation, lower blood loss, shorter hospital stay, and lower cost, recent research on the role of instability in disc herniation has made fusion techniques popular among spinal surgeons. The authors compare the postoperative outcomes of posterior lumbar interbody fusion (PLIF) and repeat discectomy for same-level recurrent disc herniation.

Methods:

The patients included had previously undergone discectomy and presented with a same-level recurrent lumbar disc herniation. The patients were placed into two groups: 1) discectomy only, 2) PLIF based on the absence or presence of segmental instability. Preoperative and postoperative Oswestry disability index scores, duration of surgery, blood loss, duration of hospitalization, and complications were analyzed.

Results:

The repeat discectomy and fusion groups had 40 and 34 patients, respectively. The patients were followed up for 2.68 (1–4) years. There was no difference in the duration of hospitalization (3.73 vs. 3.29 days P=0.581) and operative time (101.25 vs. 108.82 mins, P=0.48). Repeat discectomy had lower intraoperative blood loss, 88.75 ml (50–150) versus 111.47 ml (30–250) in PLIF (P=0.289). PLIF had better ODI pain score 4.21 (0–10) versus 9.27 (0–20) (P-value of 0.018). Recurrence was 22.5% in repeat discectomy versus 0 in PLIF.

Conclusion:

PLIF and repeat discectomy for recurrent lumbar disc herniation have comparable intraoperative blood loss, duration of surgery, and hospital stay. PLIF is associated with lower durotomy rates and better long-term pain control than discectomy. This is due to recurrence and progression of degenerative process in discectomy patients, which are eliminated and slowed, respectively, by PLIF.
Clinically amyopathic dermatomyositis associated with cutaneous ulcerations: a case-based review
Authors: De Jesus Alice Viana , De Souza Jean Marcos
Published: January 2024

Introduction and importance:

Dermatomyositis (DM) is an autoimmune myopathy primarily affecting both muscles and skin. When muscle weakness is not clinically apparent, but characteristic skin lesions are present, the condition is referred to as clinically amyopathic dermatomyositis (CADM).

Case presentation:

The authors present the case of a 52-year-old female with a typical DM rash, interstitial pneumonia, and multiple skin ulcers. The skin biopsy was consistent with DM, and there were no signs of muscle involvement. Myositis-related and myositis-specific autoantibodies were also negative. Significant improvement was not observed until the patient received successive monthly pulses of methylprednisolone and the introduction of methotrexate. This treatment regimen allowed for the complete tapering of prednisone and resulted in sustained disease control.

Clinical discussion:

In addition to the case presentation, a narrative literature review was conducted using the MEDLINE database, and an evidence-based treatment flowchart is proposed. CADM is a subtype of DM, related to higher incidences of interstitial lung disease, skin vasculopathy and malignancy. When ulcers or interstitial pneumonia are present, treatment should be early and aggressive. Active screening for neoplasms is recommended, particularly within the first 5 years.

Conclusion:

The authors presented a case of seronegative CADM featuring skin vasculopathy, successfully treated with consecutive methylprednisolone pulses. Our literature review emphasized the importance of focused CADM management trials, highlighting the need for further research.
Spiral strapping for improving upper extremity motor functions in individuals with stroke: A randomized controlled trial
Authors: Abd El-Kafy Ehab Mohamed , Alayat Mohamad Salaheldien , Alwhaibi Reem M. , Basuodan Reem M.
Published: January 2024

Background:

The rehabilitation process for the upper extremities of individuals with stroke requires therapists to use splints for supportive and corrective purposes. The aim of this study was to assess the effectiveness of spiral strapping in inhibiting spasticity and improving the upper extremity motor functions of individuals with chronic stroke.

Methods:

Forty Saudi individuals aged 50–60 years with chronic stroke participated in this study. Their degrees of spasticity according to the Modified Ashworth Scale ranged across grades 1, 1+, and 2. Participants were randomly assigned to experimental and control groups. Participants in both groups received 1 h of conventional physical therapy for 3 d/wk to improve the motor functions of their upper extremities. In addition, participants in the experimental group wore an upper-limb spiral strapping with a hand splint 10 h/d for 6 d/wk. The treatment program for both groups was delivered for 4 weeks. Changes in the scores of Action Research Arm Test for elbow joint spasticity, active range of motion of the shoulder, elbow, and forearm joints, and hand grip strength were evaluated before and after treatment in both groups.

Results:

Significant improvements in all measured variables after treatment were reported in both groups, except for elbow joint spasticity in the control group. The experimental group showed significant post-treatment improvement in the scores for all measured variables compared with the control group.

Conclusions:

Spiral strapping was beneficial in inhibiting mild degrees of spasticity and improving the motor functions of the upper extremities of stroke patients.
Evaluating Provider Perceptions of Telehealth Utility in Outpatient Rheumatology Telehealth Encounters
Authors: Howe Catherine , Smith Isaac D. , Coles Theresa M. , Overton Robert , Economou-Zavlanos Nicoleta , Solomon Mary J. , Doss Jayanth , Henao Ricardo , Clowse Megan E. B. , Leverenz David L.
Published: January 2024

Objective

This study aims to explore the factors associated with rheumatology providers' perceptions of telehealth utility in real-world telehealth encounters.

Methods

From September 14, 2020 to January 31, 2021, 6 providers at an academic medical center rated their telehealth visits according to perceived utility in making treatment decisions using the following Telehealth Utility Score (TUS) (1 = very low utility to 5 = very high utility). Modified Poisson regression models were used to assess the association between TUS scores and encounter diagnoses, disease activity measures, and immunomodulatory therapy changes during the encounter.

Results

A total of 481 telehealth encounters were examined, of which 191 (39.7%) were rated as “low telehealth utility” (TUS 1–3) and 290 (60.3%) were rated as “high telehealth utility” (TUS 4–5). Encounters with a diagnosis of inflammatory arthritis were significantly less likely to be rated as high telehealth utility (adjusted relative risk [aRR], 0.8061; p = 0.004), especially in those with a concurrent noninflammatory musculoskeletal diagnosis (aRR, 0.54; p = 0.006). Other factors significantly associated with low telehealth utility included higher disease activity according to current and prior RAPID3 scores (aRR, 0.87 and aRR, 0.89, respectively; p < 0.001) and provider global scores (aRR, 0.83; p < 0.001), as well as an increase in immunomodulatory therapy (aRR, 0.70; p = 0.015).

Conclusions

Provider perceptions of telehealth utility in real-world encounters are significantly associated with patient diagnoses, current and prior disease activity, and the need for changes in immunomodulatory therapy. These findings inform efforts to optimize the appropriate utilization of telehealth in rheumatology.
Incidental Bleeding Gastrointestinal Stromal Tumor Identified on 99mTc-RBC Scintigraphy
Authors: Wu Chenxi , Menshikova Ekaterina , Sethi Ila
Published: January 2024

Various pathologies could lead to occult gastrointestinal (GI) bleeding. Here we report the case of a 73-year-old woman who presented with hematochezia and syncope, and was found to have a large bleeding GI stromal tumor incidentally from99mTc-RBC scintigraphy. This study was done after negative workup with CT angiography, colonoscopy, and capsule endoscopy for the source of GI bleeding. Final pathology confirmed the mass being a low-grade GI stromal tumor after exploratory laparotomy.
Comparative efficacy of various pharmacologic treatments for alcohol withdrawal syndrome: a systematic review and network meta-analysis
Authors: Qu Li , Ma Xue-Ping , Simayi Alimujiang , Wang Xiao-Li , Xu Gui-Ping
Published: January 2024

This study was to compare multiple classes of medications and medication combinations to find alternatives or additives for patients not applicable to benzodiazepines (BZDs). We performed a network meta-analysis to assess the comparative effect of 11 pharmacologic treatments in patients with alcohol withdrawal syndrome. Forty-one studies were included, comprising a total sample size of 4187 participants. The pooled results from the randomized controlled trials showed that there was no significant difference in the Clinical Institute Withdrawal Assessment-Alcohol, revised (CIWA-Ar) reduction with other medications or medication combinations compared to BZDs. Compared to BZDs, the mean difference in ICU length of stay of anticonvulsants + BZDs was −1.71 days (95% CI = −2.82, −0.59). Efficacy rankings from cohort studies showed that anticonvulsant + BZDs were superior to other treatments in reducing CIWA-Ar scores and reducing the length of stay in the ICU. Synthesis results from randomized controlled trials indicate that there are currently no data suggesting that other medications or medication combinations can fully replace BZDs. However, synthetic results from observational studies have shown that BZDs are effective in the context of adjuvant anticonvulsant therapy, particularly with early use of gabapentin in combination with BZDs in the treatment of alcohol withdrawal syndrome, which represents a promising treatment option.
Rhabdomyolysis during adjunctive treatment with cariprazine in a clozapine-resistant schizophrenia patient
Authors: Lommer Kilian , Tutzer Franziska , Hofer Alex
Published: January 2024

We report the case of a 49-year-old male treatment-resistant schizophrenia patient, whose treatment with clozapine and sertraline was supplemented with cariprazine 1.5 mg/day while regularly presenting for electroconvulsive therapy. After 3 weeks of adjunctive treatment with cariprazine, blood tests revealed pronounced signs of rhabdomyolysis, including a creatine kinase serum level of 20 386 U/L and an AST serum level of 696 U/L. Clinically, the patient did not report somatic symptoms other than mild back pain. After discontinuation of cariprazine and normal saline infusion, the above-mentioned findings resolved rapidly. Although very rare, rhabdomyolysis can be a potentially dangerous side effect of cariprazine and clinicians should be aware of its possible occurrence.
A comprehensive overview of post-stroke depression treatment options
Authors: Raggi Alberto , Serretti Alessandro , Ferri Raffaele
Published: January 2024

Nearly one-third of all stroke patients develop depression at any time after a stroke, and its presence is associated with unfavorable outcomes. This narrative review aims to provide a synopsis of possible pharmacological and non-pharmacological treatment modalities for post-stroke depression (PSD). Several studies have demonstrated the efficacy and safety of selective serotonin reuptake inhibitors in treating the symptoms of this clinical condition. The treatment of PSD has been recently enhanced by innovative approaches, such as cognitive-behavioral therapy, virtual reality, telehealth, repetitive transcranial magnetic stimulation, and non-conventional therapies, which might improve depression treatment in stroke survivors. Future high-quality randomized controlled trials are necessary to confirm this hypothesis.
Temporal clustering of social interactions trades-off disease spreading and knowledge diffusion
Authors: Cencetti Giulia , Lucchini Lorenzo , Santin Gabriele , Battiston Federico , Moro Esteban , Pentland Alex , Lepri Bruno
Published: January 2024

Non-pharmaceutical measures such as preventive quarantines, remote working, school and workplace closures, lockdowns, etc. have shown effectiveness from an epidemic control perspective; however, they have also significant negative consequences on social life and relationships, work routines and community engagement. In particular, complex ideas, work and school collaborations, innovative discoveries and resilient norms formation and maintenance, which often require face-to-face interactions of two or more parties to be developed and synergically coordinated, are particularly affected. In this study, we propose an alternative hybrid solution that balances the slowdown of epidemic diffusion with the preservation of face-to-face interactions, that we test simulating a disease and a knowledge spreading simultaneously on a network of contacts. Our approach involves a two-step partitioning of the population. First, we tune the level of node clustering, creating ‘social bubbles’ with increased contacts within each bubble and fewer outside, while maintaining the average number of contacts in each network. Second, we tune the level of temporal clustering by pairing, for a certain time interval, nodes from specific social bubbles. Our results demonstrate that a hybrid approach can achieve better trade-offs between epidemic control and complex knowledge diffusion. The versatility of our model enables tuning and refining clustering levels to optimally achieve the desired trade-off, based on the potentially changing characteristics of a disease or knowledge diffusion process.
Exploring the relationships between psychological variables and loot box engagement, part 2: exploratory analyses of complex relationships
Authors: Spicer Stuart Gordon , Close James , Nicklin Laura Louise , Uther Maria , Whalley Ben , Fullwood Chris , Parke Jonathan , Lloyd Joanne , Lloyd Helen
Published: January 2024

In a pre-registered survey linked to this paper (Exploring the relationships between psychological variables and loot box engagement, part 1: pre-registered hypotheses), we confirmed bivariate associations between engagement with loot boxes (purchasable randomized rewards in video games) and measures of problem gambling, problem video gaming, impulsivity, gambling cognitions, experiences of game-related ‘flow’, psychological distress and reduced wellbeing. However, these variables have complex relationships, so to gain further insights, we analysed the dataset (1495 gamers who purchase loot boxes and 1223 purchasers of non-randomized content) in a series of Bayesian mixed-effects multiple regressions with a zero-inflation component. The results challenge some well-established results in the literature, including associations between loot box engagement and problematic gambling measures, instead suggesting that this relationship might be underpinned by shared variance with problem video gaming and gambling-related cognitions. An entirely novel discovery revealed a complex interaction between experiences of flow and loot box engagement. Distress and wellbeing are both (somewhat contradictorily) predictive of participants engaging with loot boxes, but neither correlate with increasing loot box risky engagement/spend (among those who engage). Our findings unravel some of the nuances underpinning loot box engagement, yet remain consistent with narratives that policy action on loot boxes will have benefits for harm minimization.
Metagenomics analysis of mice gut to unravel the role of metal exposure and piperine
Authors: Kaur Ravidarshdeep , Singh Dhirendra Pratap , Rawal Rakesh
Published: January 2024

The gut and intestinal microbiota, consisting of trillions of microorganisms inhabiting the human gastrointestinal tract. It plays a crucial role in human health leading to understanding the dynamic crosstalk of host-microbe interaction in the gut and has become necessary for the detection, prevention, or therapy of diseases. Gut microbiota deviations are linked with many diseases, suggesting that various pathways involved in immunity, energy, lipid, and glucose metabolism are affected. Further, it is also altered by external insults such as metal toxicity, antibiotics and pesticides. Heavy metals like arsenic, mercury, cadmium and chromium are one of the well-studied classes of environmental pollutants. Mouse models have become the model of choice for most studies in this emerging field, as they allow perturbations in the gut microbiota to be studied in a controlled experimental setup. Here, we investigate the composition and diversity of intestinal microbes utilizing cecal samples from different intervention groups: arsenic exposure (As(III)), arsenic and piperine co-administration (As+Pp), piperine per se and control group. We obtained DNA samples from these groups and performed PCR amplification and sequencing of the 16S V3-V4 region. The findings showed shift in microbial composition and abundance among different intervention groups, revealing taxa that may contribute to the microbial diversity.
Efficiency and novelty of using environmental swabs for dry surface biofilm recovery.
Authors: Watson Fergus , Wilks Sandra , Chewins John , Keevil Bill
Published: January 2024

Studies on the epidemiology of dry surface biofilms within healthcare has shown an almost universal distribution across frequently touched items.  Despite a growing body of evidence for dry surface biofilms in hospitals little attention has been paid to the recovery capacity of techniques used to detect these microbial communities. Biofilms are inherently difficult to remove from surfaces due to adhesive substances within their matrix and may act as sources of infection but to what extent is largely unknown. In this study we evaluate the recovery efficiencies of commonly used environmental swabs against dry surface biofilms containing 7.24-Log10 Acinetobacter baumannii/cm2, using a drip flow reactor and desiccation cycle. Biofilm presence was visually confirmed using episcopic differential interference contrast microscopy combined with epifluorescence and quantified using sonicated viable plate counts. The swab materials used comprised of foam, viscose and cotton, all of which were pre-moistened using a buffer solution. The surfaces were vigorously swabbed by each material type and the resultant microbe populations for both swabs and remaining dry surface biofilms were quantified. Our results found foam tipped swabs to be superior, detecting on average 30% of the original dry surface biofilm contamination; followed by viscose (6%) and cotton (3%). However, no distinct difference was revealed in the concentration of microbes remaining on the surface after swabbing for each swab type suggesting there is variation in the capacity for each swab to release biofilm associated microorganisms. We conclude whilst environmental swabs do possess the ability to detect biofilms on dry surfaces; the reduced efficiencies are likely to cause an underestimation of the microbes present and should be considered during clinical application.
Genome sequence of the plant-growth-promoting bacterium Bacillus velezensis EU07
Authors: Baysal Omur , Studholme David , Jimenez-Quiros Catherine , Tor Mahmut
Published: January 2024

Many Gram-positive spore-forming rhizobacteria of the genus Bacillus show potential as biocontrol biopesticides agricultural that promise improved sustainability and ecologically safety in agriculture. Here we present a draft-quality genome sequence for Bacillus velezensis EU07, which shows growth-promotion in tomato plants and biocontrol against fusarium head blight. We found that the genome of EU07 is almost identical to that of the commercially used strain QST713 but identified 46 single-nucleotide differences that distinguish these strains from each other. The availability of this genome sequence will facilitate future efforts to unravel the genetic and molecular basis for its beneficial properties.
Light-by-light scattering in ultraperipheral collisions of heavy ions at two future detectors
Authors: Jucha Paweł , Kłusek-Gawenda Mariola , Szczurek Antoni
Published: January 2024

We discuss possible future studies of photon-photon (light-by-light) scattering using a planned FoCal and ALICE 3 detectors. We include different mechanisms of γγ→γγ scattering such as double-hadronic photon fluctuations, t/u-channel neutral pion exchange or resonance excitations (γγ→R) and deexcitation (R→γγ). The broad range of (pseudo)rapidities and lower cuts on transverse momenta open a necessity to consider not only dominant box contributions but also other subleading contributions. Here we include low mass resonant R=π0, η,

η

′

contributions. The resonance contributions give intermediate photon transverse momenta. However, these contributions can be eliminated by imposing windows on diphoton invariant mass. We study and quantify individual box contributions (leptonic, quarkish). The electron/positron boxes dominate at low Mγγ<1  GeV diphoton invariant masses. The PbPb→PbPbγγ cross section is calculated within equivalent photon approximation in the impact parameter space. Several differential distributions are presented and discussed. We consider four different kinematic regions. We predict a cross section in the (mb-b) range for typical ALICE 3 cuts, a few orders of magnitude larger than for the current ATLAS or CMS experiments. We also consider the two-π0 background which can, in principle, be eliminated at the new kinematical range for the ALICE 3 measurements by imposing dedicated cuts on diphoton transverse momentum and/or so-called vector asymmetry.

Published by the American Physical Society
2024
Light-Induced Ideal Weyl Semimetal in HgTe via Nonlinear Phononics
Authors: Shin Dongbin , Rubio Angel , Tang Peizhe
Published: January 2024

Interactions between light and matter allow the realization of out-of-equilibrium states in quantum solids. In particular, nonlinear phononics is one of the most efficient approaches to realizing the stationary electronic state in nonequilibrium. Herein, by an extended molecular dynamics method, we identify that long-lived light-driven quasistationary geometry could stabilize the topological nature in the material family of HgTe compounds. We show that coherent excitation of the infrared-active phonon mode results in a distortion of the atomic geometry with a lifetime of several picoseconds. We show that four Weyl points are located exactly at the Fermi level in this nonequilibrium geometry, making it an ideal long-lived metastable Weyl semimetal. We propose that such a metastable topological phase can be identified by photoelectron spectroscopy of the Fermi arc surface states or ultrafast pump-probe transport measurements of the nonlinear Hall effect.

Published by the American Physical Society
2024
Implementing shared service centres in Big 4 audit firms: an exploratory study guided by institutional theory
Authors: Aschauer Ewald , Quick Reiner
Published: January 2024

Purpose

This study aims to investigate why and how shared service centres (SSCs) are implemented as well as how they affect audit firm practice and audit quality.

Design/methodology/approach

In this qualitative study guided by the theoretical framework of institutional theory, the authors conducted 25 semi-structured interviews in seven European countries, including 16 interviews with audit partners from Big 4 firms, 6 with audit team members, 2 with interviewees from second-tier audit firms and 1 with a member of an oversight body.

Findings

The authors show that the central rationale for audit firms to implement SSCs is economic rather than external legitimacy. The authors find that SSC implementation has substantial effects on audit practices, particularly those related to standardisation, coordination and monitoring activities. The authors also highlight the potential impacts on audit quality.

Originality/value

By exploring the motivation for and effects of SSC implementation amongst audit firms, the authors offer insights into the best practices related to subsequent change processes and audit quality.
Effect of ultraviolet light on the corrosion behavior of weathering steel in simulated marine atmospheric environment
Authors: Su Shuo , Zhu Xiong-Tao , Fan Hong-Qiang
Published: January 2024

Purpose

This paper aims to study the effect of ultraviolet (UV) light on the corrosion behavior of BC550 weathering steel in simulated marine atmospheric environment.

Design/methodology/approach

The effect of UV light on the corrosion behavior of BC550 weathering steel in simulated marine atmospheric environments were investigated by the corrosion weight gain experiment, in situ electrochemical noise, scanning electron microscope and X-ray diffraction.

Findings

UV light accelerated the corrosion process of BC550 weathering steel in the simulated marine atmospheric environment during the first 168 h. The maximum influence factor of UV light was 0.32, and it was only 0.08 after 168 h of corrosion process.

Originality/value

As the extension of corrosion time, the thickness and density of the corrosion product layer increased, which weakened the acceleration effect of UV light.
Demand-driven approach of vocational education and training (VET) and experiential learning: a thematic analysis through systematic literature review (SLR)
Authors: Gupta Shankar Lal , Mittal Arun , Singh Shilpa , Dash Debendra Nath
Published: January 2024

Purpose

This study investigates the various themes around the demand-driven approach of vocational education and training (VET). The study focuses on investigating two major aspects of VET. Firstly, the extant literature has been systematically classified based on seven parameters: Geography, Focus on Vocational Education, Research Methods, Economic Sector, Origin of Study, Type of Training and Level of Skill. Secondly, this study has explored various themes around the VET implementation, performance gaps and road ahead.

Design/methodology/approach

Thematic analysis with the systematic literature review (SLR) method is applied to 50 research papers on VET, published between 2011 and 2022.

Findings

This systematic review has found that experiential compliments VET and VET is the medium of skill development. Further, it was extracted through themes that VET may help ensure alternate employment in rural areas and contribute to micro- and macro-level economic development. Also, there is a requirement to adopt a demand-driven approach to VET by localizing VT content and delivery.

Research limitations/implications

The study's findings are directed towards the need for demand-driven and customized VET. This study also explores many potential areas for further empirical research through various themes.

Originality/value

This study is a novel effort that extracts the themes constituting the effect of VETs along with the descriptive analysis of the extant literature using the SLR approach. The study has rationalized the findings by providing due coding to various parameters in the previous studies under investigation.