bluuebunny/crossref_metadata_2025 huggingface dataset:
視死若死：論波東斯基作品中的記憶創造
Authors: 王曉華 王曉華
Published: March 2023

比起將波東斯基作品中的各種「死亡」具體化地圍繞在納粹大屠殺及其受難者身上，死亡此一主題在這位藝術家的創作裡，更直接關乎的或許是如何面對死亡本身。於是，若總是需要有點什麼東西才能供人以茲悼念，在波東斯基的作品裡面所憑藉的恐怕不再是被悼念者的生平種種與言行事蹟，它甚至毋須一個名字或姓氏。相反的，本文嘗試指出，正因為波東斯基不曾企圖將死亡視為死亡以外的其他之物，在其與死亡有關的每一件作品中，死亡遂不僅成為他緬懷記憶已逝者的起點，並且也是在記憶中唯一被記下來的事物。而根據記憶唯有能在以死亡哀悼死亡之時，方得以創生所開展的論述中軸，本文則將進一步論證，波東斯基如何透過一句簡單的話語自我判死，進而要求作為波東斯基後死者們的觀眾，如同他以其極富個人色彩的祭悼所親自示範的那樣，必得亦將他作品當中的死亡，也化成為自己的記憶。

 

The late French artist Christian Boltanski’s works, with their suggestions of countless deaths, were often said to evoke the Holocaust and the Jewish victims of Nazi persecution. Yet his installations dealt with the theme of death were surprisingly more directly about how do people face death in itself. Therefore, if people always need something to offer their condolences, it is probably no longer via the life stories, words and actions of the dead from Boltanski’s work. Grieving doesn’t even need a first name or a surname. On the contrary, this article attempts to prove that Boltanski does not intend to see death as something else other than death itself. Death does not only become the starting point for his memory of the deceased in each of his works related to the theme of death but also the only thing that is remembered in his memory. According to the core thought of the discourse that memory can only be created while mourning the death as death itself, this article continues to argue that how Boltanski sentenced himself to death through a concise statement and then asked all the after-dead of him must also turn the death in into their own memory and eulogy, just as he demonstrated with his extremely personal manner of mourning in his work.

 
Building Learning Analysis System with GQM Methodology and ELK Stack
Authors: Nien-Lin Hsueh Nien-Lin Hsueh , Nien-Lin Hsueh Jun-Jie Wang , Jun-Jie Wang Daramsene Bilegjargal
Published: March 2023

With the development of Internet technology, Massive Open Online Courses (MOOCs) are becoming popular around the world, and more and more people are learning new knowledge through online learning platforms. Learners generate a lot of information on learning platforms every day, and most of the information is recorded in logs. However, it is difficult to start to extract valuable information from the huge and messy log data of learning platforms, which requires a methodology to guide and a lot of time and cost to process the data. Therefore, this research proposes a data analysis process, using the GQM (Goal Question Metric) method as a guide for the analysis process combined with the Banerjee analysis model to build a series of question lists and metrics to evaluate students’ learning behavior performance, and using the ELK Stack (Elasticsearch Logstash Kibana) as an analysis environment to solve the problem of data processing. Finally, we conduct a case study of a programming course in the OpenEdu e-learning platform to help educators transform the log data into analyzable information to understand students’ learning behaviors in the online course and to propose effective decisions for improving learning outcomes.

 
Categorical Learning-based Line-up Prediction in the Drafting Process of MOBA Games
Authors: Run-Lu Zhu Run-Lu Zhu , Run-Lu Zhu Jie Wang , Jie Wang Sheng-Jie Zhao
Published: March 2023

In recent years, the e-sports industry has witnessed a rapid development, setting a wave of social and economic influence all over the world. Among these, multiplayer online battle arena (MOBA) games, represented by Dota2 account for the largest share in the number of games, audience, and prizes. As the beginning of the MOBA games, the drafting phase is of great importance due to its impact on the outcome of the game. Therefore, line-up prediction in the drafting process is an important research field in e-sports. Nonetheless, different MOBA games have different hero pools, different rules for drafting, and different non-player factors, while the available game data are sparse, hindering the prediction of line-up in the drafting phase. To solve this problem, we i) identify the key steps in lineup prediction through statistical analysis, ii) based on which we propose an orderless prediction method that achieves 7% higher accuracy than existing models, and iii) further improve the accuracy by 1.6% with an attention layer in line-up predictions. Our finding of orderless key steps in MOBA game lineup drafting may also be used to expand the lineup dataset, which is crutial to learning-based automatic game analysis.

 
Blockchain-Oriented Data Exchange Protocol With Traceability and Revocation for Smart Grid
Authors: Prince Silas Kwesi Oberko Prince Silas Kwesi Oberko , Prince Silas Kwesi Oberko Tianang Yao , Tianang Yao Hu Xiong , Hu Xiong Saru Kumari , Saru Kumari Sachin Kumar
Published: March 2023

The smart energy system (SES) encourages data administration and information services developments, particularly smart grids. Presently, numerous SESs cloud environments are accessible to smart grids. Nonetheless, because of the semi-credible character of the SES cloud environments, achieving secured access, information storage, updates, deletion, tracing, and revocation of ill-disposed clients is a genuine concern. In this publication, an Ethereum blockchain-oriented secured access regulation design upholding traceability and revocability is offered for smart grids to resolve these problems. The blockchain implements unified identity verification and saves all public-keys, users’ attribute sets, and revocable lists. The system administrator creates system parameters and sends private-keys to users. The domain administrator prepares the domain’s security and privacy-preservation policies and executes encryption procedures. If the attributes correspond with the access policy and the user’s ID is unrevoked, they could acquire interim-decryption capabilities from the edge/cloud servers. Tracking malevolent users for revocation is applicable throughout all stages, ensuring the system is secured under Decisional-Bilinear-Diffie-Hellman (DBDH) complex theory and can withstand multi-attacks. Analysis revealed the size of the public/private keys to be shorter, contrary to relevant schemes. The overhead duration is less for generating the public-key, data encryption, and decryption phases.

 
IoETTS: A Decentralized Blockchain-based Trusted Time-stamping Scheme for Internet of Energy
Authors: Bin Qian Bin Qian , Bin Qian Yi Luo , Yi Luo Jiaxiang Ou , Jiaxiang Ou Yong Xiao , Yong Xiao Houpeng Hu
Published: March 2023

As a new-style smart grid, Internet of Energy (IoE) is important and how to provide its trusted time-stamping service becomes a hit. For example, an energy provider needs to prove he/she transferred some energy to a consumer at some time. Nevertheless, traditional trusted time-stamping scheme with a central service provider is not suitable for IoE. Some researchers try to solve this problem via blockchain, due to its decentralization, traceability and tamper-proof. However, there are still chal­lenges when using blockchain. Some have to introduce another kind of central participant. Some have to face the problem of accuracy and availability when using the Bitcoin blockchain. Some have to generate too many extra transactions. To address the aforementioned problems, we propose a fully decentralized trusted time-stamping scheme without any central participant and fulfill six design goals. Compared with the state-of-the-art blockchain-based time-stamping scheme named Chronos, our scheme enjoys less cryptographic operations. We then tested our scheme in the development (local) network and two live networks of the Ethereum. The experiment shows that we have implemented a simple, effective, accurate and low-cost decentralized trusted time-stamping scheme.

 
Research on Network Security Situation Awareness and Dynamic Game Based on Deep Q Learning Network
Authors: Xian Guo Xian Guo , Xian Guo Jianing Yang , Jianing Yang Zhanhui Gang , Zhanhui Gang An Yang
Published: March 2023

In today’s increasingly complex network environment, increasingly severe network attacks, and real-time dynamic changes in offensive and defensive scenarios, network security technology has also evolved from passive security to active security technology, and expanded from analyzing unilateral security elements to comprehensively analyzing overall network security. Aiming at the problem of inaccurate assessment results due to the lack of comprehensive analysis of threat information, protection information and environmental information in existing assessment methods, this paper proposes a defensive random game model. This model analyzes threat propagation and establishes a threat propagation access relationship network, and then establishes a random game model for the game process of threat action and protection strategy implementation to solve the mixed strategy Nash equilibrium. The model comprehensively analyzes the dynamic changes of the security situation elements, ignoring the short-term situation elements that will not change, such as topology structure, service information, etc., and mainly analyzes the dynamic changes of attack information, vulnerability information, and defense measures, and predicts from the host and network levels. The experimental verification shows that the prediction method in this paper can improve the prediction accuracy and is more in line with the offensive and defensive scenarios.

 
表現異常的肝臟神經母細胞瘤
Authors: 林隆煌 林隆煌
Published: March 2023

我們報告了一例4個月大嬰兒肝臟中轉移性神經母細胞瘤的病例，神經母細胞瘤起源於原始神經脊，其產生交感神經細胞，包括交感神經節（在頸部、後縱隔、腹膜後和腹部）和腎上腺髓質細胞，因此，神經母細胞瘤可發生於腎上腺和交感神經，包括顱內、眼眶、胸、腹、盆等部位，一半以上見於腹部，臨床表現多取決於原發灶和轉移灶的位置，本病例在腹部超音波、電腦斷層與核磁共振檢查發現腫瘤類似肝母細胞瘤，後來病理切片證實為神經母細胞瘤。儘管肝母細胞瘤是兒童中最常見的原發性肝臟腫瘤，通常在出生後的前 3 年內會被診斷出來，對於嬰兒肝臟腫瘤，除肝母細胞瘤外，還必須考慮轉移性神經母細胞瘤，本文還討論了嬰兒神經母細胞瘤的臨床病理特徵和治療。肝臟中有多個不同大小的高迴聲實性腫塊作為神經母細胞瘤之臨床表現是非常罕見的，我們希望本文能提高對嬰兒肝臟神經母細胞瘤的認識以及臨床超音波醫師對於嬰兒腹部佔位性病變的瞭解。

 

Neuroblastoma is a rare cancer type that mostly affects infants and young chil-dren. It can spread to other organs, including bone marrow, bone, lymph nodes, liver, and skin. The purpose herein is to present the case of a four-month-old male infant with no prior systemic disease. The patient’s father discovered the abdominal disten-sion two months before presentation at our center. Plain abdominal radiograph showed hepatomegaly; abdominal ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI)revealed multiple solid masses of varying sizes affecting two liver lobes, which we suspected as hepatoblastoma or metastatic neuroblastoma. The patient then underwent open biopsy and pathology indicated neuroblastoma. He then received chemotherapy. Three months later, follow-up liver CT showed significant tumor resolution and urine vanillylmandelic acid (VMA)had dropped to a normal value (1.14 mg/day). The patient is presently stable. Hepatoblastoma is the most common primary liver tumor in children and is typically diagnosed within the first three years of life; nevertheless, in addition to hepatoblastoma, metastatic neuro-blastoma must also be considered in infants.

 
“Long as There’s Capitalism, Baby”: The Relevancy of The American Clock
Authors: Lee E. Andrew
Published: March 2023

abstract

With millions of Americans leaving the workplace during the Great Resignation, Arthur Miller’s 1980 play The American Clock continues to be a relevant and prescient barometer for our current socioeconomic climate. Whether Americans were speculating in penny stocks leading up to the Great Depression or using online platforms to bet on “meme stocks” and cryptocurrency today, or whether naively trusting in Rockefeller or Elon Musk as economic saviors spouting esoteric pecuniary wisdom, Miller’s play is a timeless mirror reflecting the foibles of human nature. Miller’s adaptation of historical figures such as Jesse Livermore not only scrutinizes the greed and gullibility of 1920s America but also informs current economic and social dynamics. Like much of Miller’s work, the play includes autobiographical elements, with the Baum family corresponding to the Miller family’s experience during the Depression. This article demonstrates how The American Clock remains relevant in the twenty-first century.
Covering Up the Cracks: Arthur Miller, Twenty One Pilots, and the American Literature of Neurosis
Authors: Henning John
Published: March 2023

abstract

In December 2009, a three-piece basement band called Twenty One Pilots independently released a self-titled debut studio album. The name, front man Tyler Joseph has disclosed on various occasions, is inspired by Arthur Miller’s All My Sons—in which Joe Keller’s decision to knowingly distribute defective cylinder heads causes twenty-one pilots to crash in Australia during World War II. This article considers the widely acknowledged, though thus far academically unexplored, relationship between Miller and Joseph’s texts. Though these two figures—the playwright and the pop star—may seem disparate at first glance, there are a number of “creative images” from Miller’s oeuvre that seem to uncannily reappear in Joseph’s lyricism—as the author shows. The exercise of holding these images up alongside each other yields a collection of telling insights into mythologized father figures, transplanted creative utterances, and an enduring “literature of neurosis.”
On Grounding Ethical Values in the Human Life Form
Authors: Rasmussen Douglas B. , Den Uyl Douglas J.
Published: March 2023

Benjamin Lipscomb (The Women Are Up to Something) and Clare Mac Cumhaill and Rachel Wiseman (Metaphysical Animals) have written books discussing the same four women philosophers—Elizabeth Anscombe, Philippa Foot, Mary Midgley, and Iris Murdoch—and their rise to prominence in the almost exclusively male-dominated academies of Oxford and Cambridge universities. This review focuses on these philosophers’ intellectual contributions, with special attention given to the Aristotelian character of their views in the face of an opposing philosophical regimen. We conclude with a brief reflection on Ayn Rand’s moral philosophy in light of the contributions made by these four women philosophers.
Ayn Rand and Russian Nihilism Revisited
Authors: Weinacht Aaron
Published: March 2023

Ayn Rand and the Russian Intelligentsia, by Derek Off ord, deals with both the origins and the influence of Rand’s thought. On the former, Off ord places Rand squarely and persuasively within the Russian intelligentsia tradition. On the latter, and less convincingly, the author discusses Rand as an “icon” of an American “Right” that remains largely undefined.
ROB ANALYSIS ON THE COAST OF SEMARANG CITY (CENTRAL JAVA, INDONESIA) ON MAY 23, 2022 BASED ON TIDAL DATA AND INUNDATION DISTRIBUTION
Authors: Setiyono Heryoso , Sugianto Denny Nugroho , Helmi Muhammad , Handoyo Gentur , Pratikto Ibnu , Ario Raden
Published: March 2023

The coast of Semarang City every year always faces flood and tidal problems. Flooding is generally caused by the ongoing rainy season, while tidal flows are caused by rising Java sea levels before the interseason change. This study aims to find the relationship between the tidal incident on May 23, 2022 on the coast of Semarang City with the tidal pattern at the Port of Semarang, and find out the distribution of tidal flows based on the height of inundation in the coastal area of Semarang City. The material used is daily tide data on May 23, 2022, monthly tide data April-May 2022. Data on the distribution of high inundation was obtained based on field surveys and interviews. The results showed that the peak of java sea level elevation occurred on May 23, 2022 with an altitude at the tide staff of 210 cm. Rob occurs almost evenly along the north coast of Semarang City with different heights. The largest tidal height occurred in the Semarang Port Area, which reached a puddle height of 100 cm. There are supposes that the amount of inundation at the site is related to the land subsidence at the site that continues to occur.
Formulation And Evaluation Of MucoadhesiveBuccal Tablets (Repaglinide) For Management Of Diabetes
Authors: B Thejovathi
Published: March 2023

Repaglinide is an oral antihyperglycemic agent used for the treatment ofnon-insulin-dependent diabetes mellitus. Themain objective of the studywas to formulate and evaluatebioadhesivebuccaltablets to avoid the first pass metabolismin liver. Bioadhesive buccal tablets were prepared by direct compression methodusingbioadhesive polymers likeHPMCK4 M,HPMC K15 M,Chitosan,HPMC K100 M,Sodium CMC,Carbopol 974 P,Sodium Alginate,Gum karayaandCarbopol 941NFin different ratios. The physicochemical compatibility of drug and polymers was studied by FT-IRspectroscopy.Prepared tablets were evaluated forpermeation study through porcine buccal mucosa, in vitrodrug release, bioadhesion strength, swelling index, moisture absorbance, surface pH.
A case of successful treatment of a patient with splenic artery aneurysm, splenic vein malformation and splenomegaly
Authors:   Main Military Medical Directorate of the Ministry of Defense of the Russian Federation Moscow Russia, Chuprina Alexandr P. , Polushin Sergei Yu. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Zamsky Kirill S. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Vinogradov Evgeni V. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia
Published: March 2023

The clinical picture, diagnosis and selected option of surgical treatment of splenic artery aneurysm with splenic vein malformation and splenomegaly in a 30-year-old patient are discussed.
Evaluation of calculated glomerular filtration rate before and after endovascular correction of renal artery stenosis against the background of resistant vasorenal arterial hypertension
Authors:   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Fursov Andrej N. , Potekhin Nikolaj P. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Zakharova Elena G. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Makeeva Tat'jana G. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Gaydukov Aleksej V. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia, Gorodnichev Konstanin Yu. ,   Main Military Clinical Hospital named after academician N.N. Burdenko Russian Defense Ministry Moscow Russia
Published: March 2023

Atherosclerotic stenosis of the renal arteries is the most common cause of renovascular hypertension (RVHT) among middle-aged and elderly people. In this survey a comparative analysis of the calculated glomerular filtration rate (cGFR) in a patient with resistant renovascular hypertension (RVHT) before and after endovascular correction of atherosclerotic renal artery stenosis is given. The medical records (medical history) of 44 patients (34 men, 10 women) with RVHT were analyzed. The criterion for inclusion in the study was renal artery stenosis of more than 75% of the vessel diameter. The mean age of the patients was 50.7±7.2 years. All patients had unilateral lesion of the renal arteries. Patients were divided into three groups according to the initial level of cGFR. The patients were divided into three groups according to initial cGFR value: Group 1 included 12 patients with cGFR over 90 ml/min/1.73 m2, Group 2 — 19 patients with cGFR from 89 to 60 ml/min/1.73 m2, Group 3 — 13 patients with cGFR from 59 to 45 ml/min/1.73 m2. It was revealed that the level of blood pressure after endovascular correction of stenosis decreased significantly among all patients. At the same time, among the patients with initially preserved cGFR (from 90 ml/min/1.73 m2 and more), there was an improvement in the functional state of the kidneys, a decrease in the number of antihypertensive drugs from 3–5 to a 3-component regimen. Among the patients with initially minimally reduced cGFR (less than 90 ml/min/1.73 m2), the functional state of the kidneys did not change, and among the patients with cGFR less than 60 ml/min/1.73 m2, this state continued to worsen progressively; antihypertensive therapy did not change. During the 2-year follow-up period, restenosis of the renal arteries according to duplex scanning was not observed. When deciding whether to perform endovascular interventions for atherosclerotic stenosis of the renal arteries, it is advisable to take into account the calculated GFR data.
Uma Avaliação Comparativa dos Impactos do CPC 06 (R2) Arrendamentos sobre as Empresas de Telecomunicações, Comércio e Transporte Aéreo na B3
Authors: Lamblet Dias André , Rodrigues Silva de Lima Clarice Vitória , Ferreira da Cruz Claudia , Abreu Costa Thiago De
Published: March 2023

O presente estudo tem como objetivo avaliar os impactos da adoção da nova versão do CPC 06 (R2) nas demonstrações financeiras das empresas de Comércio, Telecomunicações e Transporte Aéreo listadas na B3. O estudo caracteriza-se como descritivo, realizado por meio de análise documental. A amostra é composta por 36 empresas definidas conforme listagem geral por setor na B3 no ano de 2020. Na avaliação, foi constatado que todas as empresas divulgaram, em suas notas explicativas, impactos ocasionados pela aplicação do CPC 06 (R2). Quanto aos tipos de contratos, o setor de transporte aéreo foi representado, principalmente, por contratos de aluguel de aeronaves, o setor comercial pelos contratos de imóveis e o de telecomunicações por aluguéis de torres, entretanto, a quantidade de contratos não foi divulgada por todas as empresas. Além disso, das 36 empresas analisadas 28 adotaram a abordagem de transição retrospectiva modificada simples, 4 a retrospectiva completa, 1 prospectiva e 3 não informaram a abordagem de transição. Com relação ao impacto no fim do exercício, o reconhecimento dos direitos de uso e passivos de arrendamento, em relação ao ativo total, o setor mais impactado percentualmente foi o de Transporte Aéreo, entre 40% e 63%, seguido pelo de Comércio e Telecomunicações, que tiveram entre 20% a 39% do seus ativos e passivos concentrados nas rubricas de arrendamentos. A contribuição do estudo é esclarecer aos usuários da informação contábil os julgamentos e seus reflexos da aplicação da nova norma nos procedimentos contábeis.
A influência dos Contratos, de Fornecimento de Bens e Serviços para o Governo Federal, no Custo de Capital das Empresas Listadas na B3
Authors: Dos Santos Jaelson Graciliano , Nossa Valcemiro , Neris Nossa Silvania , Cardoso Moreira Nádia
Published: March 2023

O objetivo deste artigo foi investigar se há influência no custo de capital das companhias listadas na Brasil, Bolsa, Balcão (B3), devido ao fato de empresas do mesmo segmento de atividade possuírem, ou não, contratos de fornecimento de bens e serviços com o Governo Federal. Esta é uma pesquisa empírica e quantitativa, que utilizou dados de empresas litadas na B3 correspondente ao período de 2010 a 2019. O teste de hipóteses ocorreu por meio de análise de regressão. Os resultados encontrados sugerem que os segmentos corporativos mais estáveis e regulados experimentam redução no custo de capital, enquanto segmentos mais susceptíveis às interferências políticas apresentam aumento no custo de capital. Tal resultado evidencia o custo político/jurídico pago pelas empresas, que é frequentemente referenciado como Custo Brasil. O estudo contribui para a teoria ao ampliar o conhecimento sobre o assunto estudado, visto que não há evidências nesse sentido no mercado brasileiro. Em termos práticos, os stakeholders (bancos, investidores, governo, etc.) podem tomar decisões com base nas evidências empíricas aqui apresentadas sobre o comportamento do custo de capital por segmento.
Is High-Fidelity Important for Human-like Virtual Avatars in Human Computer Interactions?
Authors: Cao Qiongdan , Yu Hui , Charisse Paul , Qiao Si , Stevens Brett
Published: March 2023

Survey/review study
Is High-Fidelity Important for Human-like Virtual Avatars in Human Computer Interactions?

Qiongdan Cao , Hui Yu ,*, Paul Charisse , Si Qiao , and Brett Stevens

1 University of Portsmouth, Portsmouth, PO1 2UP, UK
* Correspondence: hui.yu@port.ac.uk
 
 
Received: 2 March 2023
Accepted: 6 March 2023
Published: 27 March 2023
 

Abstract: As virtual avatars have become increasingly popular in recent years, current needs indicate that “interactivity” is crucial for inducing a positive response from users towards these avatars, especially in human computer interactions (HCI). This paper reviews recent works on high-fidelity human-like virtual avatars (e.g. high visual and motion fidelity) and discusses the critical question——“Is high-fidelity a positive choice for virtual avatars to achieve better interactions in HCI”. Furthermore, we summarise current technical approaches to developing those virtual avatars. We investigate the advantages and disadvantages of high-fidelity virtual avatars in different areas focusing on addressing the effect of motion, especially the upper body. Research shows that high-fidelity is a positive choice for virtual avatars, although it may depend on the application.
No “haughty and inaccessible ivory tower”: Laval University and Adult Education, 1930–1965
Authors: McLean Scott
Published: March 2023

Canadian universities today assert their social relevance through highlighting processes such as community engagement, knowledge mobilization, and the promotion of equity, diversity, and inclusion. Much can be learned about such processes through examining an era in which Canadian universities asserted their social relevance through another vocabulary: that of adult education and extension. This article provides a case study of adult education work undertaken at Laval University from 1930 through 1965. Through reconstructing programs and practices at Laval, this article offers insight into past and present efforts of universities to pursue educational objectives with which they are not traditionally associated. The article narrates an important chapter in Canadian educational history, and also elucidates five lessons of importance to contemporary educational scholars and leaders: beware of institution-centric thinking, know how you can help people make a living, partner with external organizations, play to your institutional strengths, and serve and learn from others.
Comparison of acute ischemic stroke care quality before and during the COVID-19 pandemic in a private tertiary hospital in metro Manila, Philippines
Authors: Delfino Jean Paolo , Carandang-Chacon Christine Anne
Published: March 2023

Background: The Coronavirus Disease 2019 (COVID-19) pandemic had disrupted established medical care systems worldwide, especially for highly time-sensitive acute conditions such as stroke. Strategies to maintain the quality of stroke care during the COVID-19 outbreak are crucial to prevent indirect mortality and disability due to suboptimal care. Objective: We conducted a single center analysis to compare the time-based measures for acute ischemic stroke care quality before and during the COVID-19 pandemic.
Methods: A retrospective study was done utilizing the Registry of Stroke Care Quality (RES-Q) database. All acute ischemic stroke patients who presented within 4.5 hours of symptom onset in Makati Medical Center were included. Patient characteristics, treatment received, in-hospital time-based measures of stroke care quality and clinical outcomes were compared between the two periods- pre-COVID-19 and COVID-19.
Results: There were 151 patients during the pre-COVID-19 period and 108 patients during the COVID-19 period who presented to the hospital with acute ischemic strokes within 4.5 hours of symptom onset. There was significantly higher NIHSS scores on admission and MRS scores on discharge during the COVID-19 period. There was no significant difference in the door-to-scan time, door-to-needle time and door-to-groin time between the two periods.
Conclusion: There is no significant change in the acute ischemic stroke care quality on the basis of in-hospital time-based measures: door-to-scan time, door-to-needle time, and door-to-groin time, between the pre-COVID-19 and COVID-19 periods. Further studies on pre-hospital challenges are recommended to identify specific targets for improvements in stroke care during pandemics.
Estrogen and progesterone in meningioma: Bridging the gap of knowledge
Authors: Ichwan Syaiful , Santoso Fabianto , Aman Renindra Ananda , Tandian David , Fachniadin Ande , Nugroho Setyo Widi
Published: March 2023

Meningiomas are primary central nervous system tumor with the highest prevalence. Meningiomas have a high recurrence rate in the same location. One of the factors thought to be associated with the frequency of meningiomas is hormonal status. However, research on this subject is still controversial. This review aims to discuss the effect of sex hormones on meningiomas. Sex hormones, especially progesterone, have been shown to play a role in tumorigenesis and meningioma recurrence. Progesterone receptors also play a role in meningioma recurrence where a low number of receptors indicates a poor prognosis. However, the molecular relationship between meningiomas at low progesterone receptor expression is still unknown. Further research is still needed to determine the role of sex hormones, especially progesterone, and their receptors, in both tumorigenesis and meningioma progression. This research ensures that new science in the field of endocrinology can be utilized for both primary preventive, secondary preventive, and therapeutic strategies for meningiomas.
Hemşirelerin Kültürel Yeterlilik ile Etnik Merkezcilik Düzeyleri Arasındaki İlişki ve Etkileyen Faktörlerin Belirlenmesi
Authors: TÜRKOĞLU Nihan , SÖNMEZ Sümeyye Betül
Published: March 2023

Amaç: Bu çalışma, hemşirelerin kültürel yeterlilik düzeyleri ve etnik merkezcilik düzeyleri ile aralarındaki ilişkinin ve etkileyen faktörlerin belirlenmesi amacıyla yapılmıştır.

Gereç ve Yöntem: Tanımlayıcı tipte olan bu araştırma, Erzurum Şehir Hastanesi'nde Ekim-Kasım 2021 tarihleri arasında çalışan 312 hemşire ile yapılmıştır. Araştırma verileri Google Form aracılığıyla "Kişisel Bilgi Formu", "Etnik Merkezcilik Ölçeği" ve "Hemşire Kültürel Yeterlilik Ölçeği" kullanılarak çevrimiçi olarak elde edilmiştir.

Bulgular: Katılımcıların Kültürel Yeterlilik Ölçeğinden 69.13±10.58, Etnik Merkezcilik Ölçeğinden 48.15±9.87 puanını aldıkları saptanmıştır. Hemşirelerin yabancı dil bilme, başka kültürlerden hasta bakma, farklı kültürlerden hastalarla bir arada olmayı isteme durumuna göre Kültürel Yeterlilik Ölçeği puanları arasında anlamlı fark bulundu. Ayrıca hemşirelerin çocuk sayısı, farklı kültürlerden hastalarla bir arada olmayı isteme ve başka kültürlerden hasta bakma durumuna göre Etnik Merkezcilik Ölçeği puanları arasında anlamlı fark bulundu. Katılımcıların Hemşire Kültürel Yeterlilik Ölçeği ile Etnik Merkezcilik ölçeği arasında negatif yönde orta düzeyde anlamlı ilişki olduğu saptanmıştır (p
An Overview of the Last-mile Distribution Development of E-commerce Logistics
Authors: Ji Minghui
Published: March 2023

Due to the continuous development of online shopping in recent years, the development of e-commerce logistics is more rapid. Consumers are generally sensitive to the timeliness of logistics distribution, especially in the last-mile distribution service, so it is of great significance to study the last-mile distribution of e-commerce logistics. Firstly, this paper selects the overall situation of documents from China and abroad, and expounds the key words and the trend of paper publication. Secondly, distribution is divided into direct distribution and indirect distribution to sort out the research status. Finally, this paper looks forward from two aspects of research perspective and research content.
The word profile of a Global Online Course for English language teachers: A corpus-based research project
Authors: Kurt Sebnem , Beck Jeanne , Alharthi Abdulrahman
Published: March 2023

Providing useful reference materials for online course participants is an important aspect for online courses. To aid a course designed to provide professional development to English language teachers from around the world, this corpus-based study investigated the frequency and coverage of Academic Word List (Coxhead, 1998), General Service List (GSL) first 1000 words (1K), and GSL second 1000 words (2K) lists. Gathering course materials and participant discussion board posts into two corpora for this study, frequency and coverage of the three base lists were calculated using AntWordProfiler and AntConc, resulting in a coverage of 9.56 % for AWL words and over 80% coverage for the two GSL lists combined in the first corpus. The high percentage of off-list words (9.75%) in the first corpus and low percentage of AWL words in the second corpus (5.23%) motivated the creation of a new word list that contains the most frequently used words outside of the AWL, GSL 1K, and GSL 2K words from the first corpus to supplement future course participants with technical words that are required to successfully complete the course.
Modern Heritage of the Middle East potentials and values: Documenting a UAE Landmark
Authors: Hafiz Dalia O
Published: March 2023

Buildings represent the identity of cities and create the memory of the nation. Architecture landmark are the ambassadors of culture and civilization of the country. The UAE modern heritage represented in the 60s, 70s, and 80s architecture signifies the memory of the country and highlights the architecture style and its influences in various periods. The national theatre of Abu Dhabi is a key landmark from the 70s era. This cultural symbol is a landmark that shaped the style of the capital city at this time. This paper is a case study that aims at understanding the architecture of the National Theatre of Abu Dhabi building as a symbol of architecture and the architect’s only building remaining in the region. The paper outcomes and findings represent an approach for evaluating and greening modern heritage buildings in the Middle East while protecting both their historical and cultural values. The research aims to provide architects, researchers, and decision makers with a capture of architectural heritage buildings documentation via BIM modelling and traditional methods.
Structural Behavior of Concrete Produced Using Palm Kernel Shell (PKS) as a Partial Substitute for Coarse Aggregate
Authors: Ifeanyi Ogunjiofor Emmanuel , Chima Amete Daniel , Chukwudubem Nwabunwanne Johnbosco
Published: March 2023

The possibility that our available resources will soon run out completely cannot be overstated. There have been series of research into alternative materials, especially materials available locally which may be useful as a substitute alternative materials used in the production of concrete. This has become necessary due to increasing costs of construction and the need of reducing stresses in the environment in order to make construction more sustainable. The goal of this research was to assess the strength of concrete made with palm kernel shell (PKS) used in place of some of the coarse material. The experiments listed below were carried out: compressive strength test, slump test, sieve analysis, and water absorption test. The concrete was created using cement, sand, coarse stones (coarse materials), and palm kernel shell. For the compressive strength test, a total of 48 cubes with dimensions of 150 mm x 150 mm x 150 mm were cast, with the ratio of these materials being 1:1.5:3 (Cement: Sand: Aggregates), by weight batch. In place of the coarse aggregate, PKS of 0%, 10%, 20%, and 30% were used. Before the compressive strength was calculated, all of the samples were cured for 7, 14, 21, and 28 days. This experiment provides insight into how much concrete’s weight could be reduced while maintaining its strength. The outcomes of these tests were compared with the control group after completion. The findings showed that adding 10% palm kernel shell(PKS) to the concrete with coarse aggregate is beneficial without significantly reducing the concrete’s strength.
Synthesis, Characterisation and Comparative Study of Hydrogel and Nanogels of Psyllium
Authors: Kumar Suman , Dharela Rohini , Chauhan Ghanshyam S
Published: March 2023

Natural polysaccharides are being explored as the matrices for attaining speciality materials for pharmaceutical, medicinal and environmental applications via chemical modification such as grafting. Psyllium polysaccharide-based hydrogels and nanogels have potential biomedical and water purification applications due to their advantageous properties such as stimulus responsiveness, biocompatibility, target drug delivery and stability. The present study aims to synthesise hydrogel and nanogels of psyllium and attain comparative data for the two to undermine their potential applications. Psyllium– cl –N,N–MBAm–poly(AAm) hydrogel (Psy-MBAm-AAm – hg) and Psyllium– cl –N,N–MBAm–poly(AAm) nanogel (Psy-MBAm-AAm – ng) were synthesised by grafting acrylamide (AAm) onto psyllium using ammonium persulphate (APS) as a free radical initiator in a redox system where N, N-methylene bisacrylamide acted as a crosslinker. The comparative study of synthesised gels was carried out by studying swelling characteristics at acidic and basic pH (7 and 4) and at varied temperatures for both matrices. The synthesised hydrogel and nanogels were subjected to characterisation by Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), and Zeta Potential Analysis to get evidence for successful synthesis and nanogel formation.
Effect of Aqueous Stem Bark Extract of Parkia Biglobosa on the Histological Morphology of Liver of Adult Wistar Rats
Authors: Ibrahim D. F , Hassan A. S , Sani A , Zakariyya A , Shema F B , Zubair R U , Riruwai G Y
Published: March 2023

People in Africa and other developing countries depend on medicinal plants. Extract of Parkia biglobosa stem bark is used in Nigerian traditional medicine to treat malaria, diarrhea and pains. This study aimed at determining the effect of aqueous stem bark extract of P.biglobosa on the histological morphology of liver in animal models. A total of 28 wistar rats weighing between 100 – 150g were used for this study out of which 12 were used for acute toxicity testing using Lorke’s method (1983), the test was carried out in two phases. In phase I, 9 adult wistar rats were divided into 3 groups and administered with 10mg/kg, 100mg/kg and 1000mg/kg orally while in phase II, 3 wistar rats were assigned into 3 groups and administered with 1600mg/kg, 2600mg/kg and 5000mg/kg respectively and both they were observed for signs of toxicity/mortality within 24hrs. The remaining 16 rats were divided into 4 groups; A, B, C and D. Group A served as control and groups B, C and D served as test groups. For 21 days, group A received normal feed and water only and then group B, C and D received oral doses of 1000mg/kg, 500mg/kg and 250mg/kg of aqueous extract of P.biglobosa stem bark respectively. A significant increase in the level of ALP, ALT and AST was observed in comparison with the control, P< 0.005 was considered statistically significant. It was shown that liver sections in group A (control) presents no histological changes while the liver section of animals treated with (1000mg/kg and 500mg/kg) of P.biglobosa aqueous extract for 21 days revealed an inflammation, vascular degeneration and vacoulation respectively. It was found that at higher doses P.biglobosa aqueous stem bark extract could be hepatotoxic.
Incidence and Comparison of Suicide in Various Phases of the Menstrual Cycle: a Systematic Review and Meta-analysis
Authors: Alnashwan Yara , Rashid Ahmed , Javaid Syed , Kharoshah Magdy , Arun M , Dsouza Haneil , Atreya Alok , Menezes Ritesh
Published: March 2023

Background: Suicide is a global health concern. There are reproductive health-related factors that are responsible for increasing the risk of female suicide. There are a number of studies examining the association between suicide and the menstrual cycle, but still, there are no conclusive findings. Aim: We aimed to pool data from all the studies reporting data on suicides and the menstrual cycle phase to report the following outcomes: incidence of suicidal deaths in the menstrual, secretory, and proliferative phases, and to find out whether the burden of suicide in the menstrual phase in particular, was more at a young age (18-35 years) or middle age (36-50years). Methods: The PubMed database was extensively searched from inception till 12th April 2022. The data for the number of events occurring for each outcome were pooled using random-effects model and forest plots were created. Results: Five articles were shortlisted for inclusion in our analysis. Incidence of suicide in the secretory phase was highest at 45.2% [95% CI, 0.367–0.537]. The incidence of suicide, when occurring in the menstrual phase, was reported to be 68.4% (95 CI, 0.317–1.052) and 31.6% (95 CI, -0.052.3–0.68) for young-aged and middle-aged victims, respectively. Conclusion: Our results demonstrate that the menstrual phase has a lower risk of mortality due to suicide when compared to the other two phases of the menstrual cycle. Nevertheless, when suicide occurred in the menstrual phase, the incidence of suicide among the younger age-group was higher than for those in the middle age-group.
Association between dietary polyunsaturated fatty acids and their concentration in blood plasma, red blood cell and semen of dogs
Authors: Pellegrino Francisco , Corrada Yanina , Picco Sebasti , Relling Alejandro , Risso Analia
Published: March 2023

Background:
In dogs, dietary omega 3 polyunsaturated fatty acids (n-3 PUFA) affect the fatty acid (FA) profile of blood plasma, erythrocyte membrane (EM) and semen, but their correlation has not yet been investigated.
Aim:
In this study, we evaluated the association between dietary PUFA and their profile in blood plasma, EM and semen of dogs, with the possibility to predict the semen profile using the values of the three first.
Methods:
Twelve male dogs received the same standard commercial diet for four weeks. The FA profile was analyzed by gas chromatography in paired diet, blood (plasma and EM determinations) and semen samples. Data were analyzed with SAS Proc Corr version 9.4. Pearson´s correlation coefficient (significant if p < 0.05) was used to assess the association of dietary FA profiles with those in blood plasma, EM and semen.
Results:
There was a positive correlation between dietary eicosapentaenoic acid (EPA) and blood plasma (r = 0.97), EM (r = 0.94) and semen (r = 0.92) EPA, and between dietary docosahexaenoic acid (DHA) and arachidonic acid (ARA) and semen DHA (r = 0.93) and ARA (r = 0.92), respectively. There was negative correlation between dihomo-gamma-linolenic acid (DGLA) in the diet and EM DGLA (r = -0.94).
Conclusion:
The dietary EPA is correlated with blood plasma, EM and semen EPA concentrations, and dietary DHA and ARA are correlated with semen DHA and ARA concentrations in dogs. These findings suggest that dietary EPA, DHA and ARA concentrations could be useful predictive markers for such concentrations in the semen of dogs.
Expression of a recombinant ASFV P30 protein and production of monoclonal antibodies
Authors: Liberti Rosrio , Colabella Claudia , Anzalone Lucia , Severi Giulio , Paolo Antonella , Casciari Cristina , Casano Anna , Giammarioli Monica , Cagiola Monica , Feliziani Francesco , Giuseppe Antonio
Published: March 2023

Background:
African Swine Fever (ASF) is an infectious disease that affects domestic pig and wild boar populations. The African Swine Fever Virus (ASFV) has a genome characterized by a very complex DNA (170-193 kb) that encodes for more than 200 different proteins. Among these, the highly immunogenic phosphoprotein p30 plays a fundamental role in the induction of specific antibodies. To date, the lack of a vaccine against the disease requires continuous studies to improve knowledge about the virus and the development of new tests in addition to virological ones.
Aim:
The aim of this work was to produce specific monoclonal antibodies (mAbs) against the p30 protein of ASFV, which could find useful applications in routine diagnostics and the implementation of new diagnostic tools.
Methods:
ASFV p30 encoding gene was amplified and used for the generation of the recombinant baculovirus by transfection of the Sf21 insect cells. The recombinant protein was analyzed by immunofluorescence assay, purified, and used for mice Balb-c immunization. The hybridomas obtained were cultured and screened, using an indirect Enzyme-linked Immunosorbent Assay (iELISA), in order to select clones that secrete the mAbs of interest.
Results:
The expression of recombinant p30 protein was assessed using direct Immunofluorescence. The purified p30 protein fractions were analyzed by Coomassie gels staining confirming the presence of bands with a molecular weight of 30 kDa and used for the immunization of Balb-c mice. Six clones of pure hybridomas secreting the specific mAbs against recombinant p30 were obtained and tested in iELISA. The mAbs were also characterized by Western blot and Immunofluorescence assay. The best results were obtained with the anti-p30 mAb 2B8E10 clone which showed high reactivity with both recombinant and viral p30 protein, respectively.
Conclusion:
In this work, a recombinant p30 protein produced in an insect cell system was purified and used to immunize Balb-c mice. Six anti-p30 mAbs-secreting hybridomas clone cells were obtained. These mAbs displayed high reactivity against the recombinant protein, but only 2B8E10 mAb showed excellent functionality against the p30 protein produced by ASFV. These results open the possibility to develop different diagnostic assays.
Perforated duodenal ulcer in a dog with gallbladder agenesis
Authors: Ciammaichella Luca , Foglia Armando , Magno Sara , Cola Veronica , Zanardi Stefano , Baldo Francesca , Pietra Marco , Morini Maria , Pisoni Luciano
Published: March 2023

Background:
Duodenal ulceration (DU) in dogs derives from different causes but has never previously been related to gallbladder agenesis (GA). GA is a rare congenital disorder in dogs and is considered a predisposing factor for DU in humans.
Case description:
A 5-month-old intact female Maltese was presented for acute vomiting and diarrhea. Abdominal ultrasound suggested duodenal perforation and absence of the gallbladder. Exploratory laparotomy was performed to treat the perforation and confirmed GA. Hepatic ductal plate malformation (DPM) was histologically diagnosed in liver biopsy, but no signs of liver dysfunction were detected by blood work at first admission. Two months later, the dog developed signs of portal hypertension and medical treatment was started. However, the clinical condition gradually worsened until liver failure and the dog was euthanized 8 months after surgery. Necropsy confirmed hepatic abnormalities.
Conclusion:
This report describes a case of DU associated with GA and DPM in a dog. As in humans, GA may represent a hepatobiliary disease predisposing to gastroduodenal ulcerations.