bluuebunny/crossref_metadata_2025 huggingface dataset:
Artistic image of Armenian mitres
Authors:   Yerevan State University, Manukyan S.S. ,   National Academy of Sciences of the Republic of Armenia
Published: December 2024

For the first time, Armenian mitres are presented as works of fine art. Embroidered with subject motives, unlike the Latin mitres from which they originated, the mitres reflect the images, symbolism, style and iconography of the monuments of Armenian church art of the 17th-19th centuries.
Inscriptions on the Reliquary of Dionysius of Suzdal: Philological Commentary
Authors:   National Research University Higher School of Economics, Lashchuk S.A.
Published: December 2024

The article presents a philological analysis of the complex of inscriptions on the reliquary of Dionysius of Suzdal (1383). Detailed readings of all inscriptions are provided, "dark places" are clarified, and a general characterization of the circle of sources, language, and syntactic structure of these texts is given. It is shown that the inscription around the cross relies on the tradition of Byzantine epigrams on reliquaries and has features of a poetic text, while the inscriptions on the relics are built on quotations and reminiscences from liturgical texts related to the tradition of venerating Passion relics. References to these texts are intended to emphasize the meaning of the Passion reliquary as an object of worship. The analysis of the composition of the dedicatory inscription, going beyond both the Russian and Byzantine formulas, allows identifying a favorable for Dionysius political message enclosed in it. Support of the Russian Science Foundation (RSF), project no. 19-18-00352, https://rscf.ru/project/19-18-00352/.
Sculpture “St. Nicolas (“Mozhaisky”)” of the second quarter of the 16th century from the Collection of the State Historical Museum
Authors: Trifonova A.N.
Published: December 2024

The article is devoted to the study of the sculpture “St. Nicolas (“Mozhaisky”)” from the State Historical Museum. Based on iconographic and stylistic analysis it is proved that the sculpture considered in the article is included in the group of carved icons of the saint of 16th century. The central objects of the group are sculptures from the Assumption Cathedral in Peremyshl (the second quarter of the 16th century) and Pskov (until 1540).
PERAN PENDIDIKAN KRISTIANI DALAM PENGUATAN KARAKTER KRISTIANI KELUARGA DI ABAD 21
Authors: Sembiring Maria Sinta
Published: December 2024

In the 21st century, humans live in an age of constant change. The changes that occur are inseparable from the development of increasingly sophisticated technology. Nowadays, all about the human life movement has become digital technology. Digital technology has a huge influence on humans and Christian families today are no exception. The advancement of digital technology is inevitable. Technology brings enormous changes to the behavior, spirituality, and truth values held by humans. Now, the value of ultimate truth is getting harder to apply. What is right and what is wrong depend on the situation. The Word of God is no longer an absolute truth to be practiced in this era, even there has an assumption that the principles of Christian life are no longer contextualized in this era. This situation illustrates that in the 21st century, the character of faithfulness to the truth of God's Word is eroding and deserves to be questioned, especially in the lives of today's youth. For this reason, Christian education is very important to be instilled in the family, so that Christian families are able to shape the character of life that is faithful to biblical truth.
Методы анализа текста на естественном языке в задаче экстрактивного информационного поиска
Authors: Перцев Ю. В.
Published: December 2024

в статье рассматривается лингво-математическое обеспечение интеллектуальных информационно-поисковых систем. Активно развивающиеся последнее десятилетие большие языковые модели, способные решать задачи информационного поиска, часто оказываются ресурсоемкими и имеют избыточный функционал при встраивании в специализированные информационные системы. Это создает необходимость разработки более легковесных методов обработки текста на естественном языке. Рассматривается экстрактивный подход к организации вопросно-ответного поиска, задача которого состоит в нахождении предложений, отвечающих на вопрос в заранее выбранном документе. В рамках организации этого подхода предлагаются методы анализа морфологии, синтаксиса и семантики естественного языка. Для реализации графового синтаксического анализа, основанного на взвешивании полного ориентированного графа искусственной нейронной сетью прямого распространения, собран корпус текстов на русском языке, содержащий 8800 предложений. Также этот корпус используется для получения набора синтаксически ориентированных векторных представлений слов, применяющегося на этапе семантического анализа, посредством модели, основанной на архитектуре непрерывного мешка слов. Механизм ранжирования предложений относительно вопроса основан на формализации семантики текста на естественном языке в виде сильно-связного ориентированного графа, выявляющего неявные содержательные закономерности языковых структур.

the paper presents the linguistic software for intelligent search systems. Large language models have been actively developing for the last decade. LLMs suitable for information search often require extensive resources and have redundant functionality when embedded into targeted information systems. Lightweight approaches to natural language processing are needed. We considered an extractive approach to a “question-answer” search intended to find sentences that answer a question in the specified document. For this, we proposed methods for analyzing the morphology, syntax, and semantics of the natural language. A corpus of Russian language texts containing 8,800 sentences was collected to implement graph-based syntax analysis with a weighting of a completely oriented graph by a forward-propagation artificial neural network. This corpus was also used to produce a set of syntax-oriented vector representations of words, applied in the semantic analysis by using a model based on a continuous bag of words architecture. The sentence ranking by relevance to the question is based on representing the semantics of the natural language text as a strongly connected directed graph, revealing implicit meaningful patterns within the language structures.
Grandparenting practices and their association with physical and mental well-being among older adults with chronic diseases in Malaysia: A cross-sectional study
Authors: Othman Sajaratulnisah , Hee Vinvie Wei Huo , Ng Clarice Jing Wen , Suhaimi Julia
Published: December 2024

Introduction: There is limited understanding of the association of grandparenting with the wellbeing of older adults with chronic diseases. This study aimed to examine grandparenting practices and their association with physical and mental well-being among older adults.
Methods: The cross-sectional study was conducted at an outpatient clinic in a tertiary hospital in the Klang Valley, Malaysia. A total of 421 older patients with grandparenting experience were interviewed. The SF-12 Version 2.0 Health Survey was utilised to assess mental and physical wellbeing. Sociodemographic information, chronic disease care and grandparenting practices were evaluated to investigate any potential relationship with physical and mental well-being.
Results: Of the participants, 80% were aged 60–74 years; 62.5% were women; and 81.4% completed secondary education. More than half of the participants voluntarily took on the role of grandparenting. The participants showed an impaired physical function but a preserved mental wellbeing. Never missing regular medication due to grandparenting and taking up grandparenting based on the circumstances were related to mental health. However, no factor was significantly associated with physical well-being.
Conclusion: Two factors are linked to improved mental well-being. In contrast, there is no significant relationship found between a decline in physical health and grandparenting practices. Further research is needed to determine the causal relationship between physical health challenges and grandparenting practices.
Effects of Organizational Culture Types on Construction Project Performance: A Competing Values Framework Approach in Ghanaian Perspective
Authors: Ackon Frank , Kheni Nongiba Alkanam , Mensah John Victor , Barajei Chelteau
Published: December 2024

Organizational culture plays a critical role in influencing various aspects of project performance. However, existing studies on the impact of specific cultural types on construction projects have produced mixed results. This research examines the effects of organizational culture types on the performance of construction projects. A descriptive cross-sectional design was adopted, utilizing a census sampling approach. Quantitative data were collected using structured questionnaires administered to 375 medium and large-size construction firms. The analysis employed both descriptive and inferential statistical methods, including correlation and regression analyses. The results revealed that market and hierarchy culture types positively influence construction project performance, while clan and adhocracy cultures do not exhibit a significant effect. Furthermore, cultural traits emphasizing external orientation, stability and control characteristic of a hybrid market-hierarchy culture were identified as stronger predictors of successful project outcomes compared to other cultural clusters. To optimize project performance, it is recommended that construction firms in Ghana transition from adhocracy-dominated cultures to hybrid market-hierarchy culture.
Enhancing Higher Education Industry Linkage: The Contribution of Tanzania Commission for Science and Technology (COSTECH), Dar es Salaam, Tanzania
Authors: Mwakasi Ramla , Issa Feisal
Published: December 2024

The study was conducted to examine the contribution of Tanzania Commission for Science and Technology (COSTECH) to higher education - Industry linkage. The specific objectives of the study included; elaborating the effectiveness of COSTECH policies on promoting innovators activities from higher education institutions, understanding the role of COSTECH on moderating higher education industry linkage, and lastly assessing the efficiency of COSTECH on linking collaborative scientific research between universities and industry. Purposive sampling was used to obtain sample units for the study. The study managed to obtain twenty three (23) respondents who provided information needed to answer specific research questions. The study findings has indicated that, the effectiveness of COSTECH to enhance HIL was demonstrated by the frameworks institutionalized by COSTECH in making use of Science and Technology Policy of 1996 and the Research and Development Policy of 2010 to protect the IP and inventions of researchers. Also by the establishment of National Fund for the Advancement of Science and technology (NFAST) with an obligation to provide grants to (R&D) , awarding funds to (STI’s) and technology transfer activities and also to provide support to technology transfer activities done by local scientists within the priorities that are pee-determined by the government. The study findings shows COSTECH execute its roles by ensuring that industry and higher learning institutions are involved in R&D conducted, through Technology and Innovation Support Centres (TISCs) and Technology Transfer Offices (TTOs), whereas the centers facilitates early engagement with industry stakeholders, aligning research with market needs. The TISCs and TTOs organize consultations, workshops, and collaborative research programs for continuous feedback. Furthermore the efficiency of COSTECH in enhancing HIL was demonstrated by its the ability to issue 45 patent applications, a successful commercialization of 15 intellectual properties and on top of that the awarding of 20 patent certificates, registration of 30 trademarks and 25 copyrights within the financial year 2023/2024. The study was concluded by mentioning that the mechanisms and foundation for HIL nourishment have been well established by COSTECH through different guidelines, frameworks and policies. Lastly The study recommendations suggested that HIL should be championed by state owned universities and firms as a starting point so as to attract other actors from the private sector.
HUBUNGAN CORPORATE REPUTATION DENGAN INTENTION TO APPLY PADA MAHASISWA
Authors: TIRTABUDI MICHELLE , HASTUTI RAHMAH , JESSICA JESSICA
Published: December 2024

This study aims to analyze the relationship between corporate reputation and intention to apply in students. Corporate reputation is considered one of the key factors that affect the perception of individuals, especially students, towards the company, which can ultimately determine the decision to apply for a job. This study uses a quantitative approach with a survey method involving 215 students from various universities. The implementation of the research was carried out from July 2024 – November 2024. The data was collected through a questionnaire that measured students' perception of the company's reputation as well as their interest in applying for jobs. The purpose of this study, among others, is to find out the relationship between corporate reputation and interest in applying for jobs. Data collection is carried out through google forms. Hypothesis testing in this study using a simple linear regression method Based on the results of the hypothesis test, p = 0.000 < 0.05 and a significance value of 0.000, So, it can be concluded that the corporate reputation variable has a significant relationship with the intention to apply variable. These findings indicate that companies with good reputations have more potential to attract younger generations to join. This research provides practical implications for companies to continue to improve their image to attract qualified prospective workers
ABSTRAKPenelitian ini bertujuan untuk menganalisis hubungan antara corporate reputation (reputasi perusahaan) dan intention to apply (minat melamar pekerjaan) pada mahasiswa. Corporate reputation dianggap sebagai salah satu faktor kunci yang memengaruhi persepsi individu terutama mahasiswa terhadap perusahaan, yang pada akhirnya dapat menentukan keputusan melamar pekerjaan. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei yang melibatkan 215 mahasiswa dari berbagai universitas. Pelaksanaan penelitian dilakukan dari bulan Juli 2024 – November 2024. Data dikumpulkan melalui kuesioner yang mengukur persepsi mahasiswa terhadap reputasi perusahaan serta minat mereka untuk melamar pekerjaan. Tujuan dari penelitian ini, yang diantaranya adalah untuk mengetahui hubungan antara Corporate reputation dengan minat melamar pekerjaan. Pengumpulan data dilakukan melalui google form. Pengujian hipotesis pada penelitian ini dengan menggunakan metode regresi linier sederhana Berdasarkan hasil uji hipotesis, p = 0,000 < 0,05 serta nilai signifikansi sebesar 0,000, Sehingga, dapat disimpulkan bahwa variabel corporate reputation memiliki hubungan yang signifikan dengan variabel intention to apply. Temuan ini mengindikasikan bahwa perusahaan dengan reputasi yang baik lebih berpotensi menarik minat generasi muda untuk bergabung. Penelitian ini memberikan implikasi praktis bagi perusahaan untuk terus meningkatkan citra mereka guna menarik calon pekerja berkualitas.
HUBUNGAN SELF-CONTROL DENGAN ADIKSI TIKTOK PADA EMERGING ADULTHOOD
Authors: SAPUTRA NICO , HASTUTI RAHMAH
Published: December 2024

Tiktok addiction is becoming an increasingly common phenomenon among emerging adulthood, characterized by excessive use and negative impacts on mental health, productivity, and social relationships. This study aims to examine the relationship between self-control and Tiktok addiction in individuals aged 18-25 years who are classified as emerging adulthood. The method used is quantitative research with purposive sampling technique. Data were obtained from 200 participants domiciled in Jabodetabek through filling out an online questionnaire using the Brief Self-Control Scale (BSCS) and an adaptation of the Bergen Social Media Addiction Scale (BSMAS) to measure Tiktok addiction. The results of the analysis showed a significant negative relationship between self-control and Tiktok addiction (r = ?0.806; p < 0.05), meaning that higher levels of self-control are associated with a lower tendency for Tiktok addiction. The inhibition and initiation dimensions in self-control each contribute significantly to the decrease in Tiktok addiction with correlation values ??of r = ?0.793 and r = ?0.761. This study confirms the importance of self-control in reducing the risk of social media addiction, especially Tiktok, in emerging adulthood.
ABSTRAKAdiksi Tiktok menjadi fenomena yang semakin umum di kalangan emerging adulthood, ditandai dengan penggunaan yang berlebihan dan dampak negatif terhadap kesehatan mental, produktivitas, serta hubungan sosial. Penelitian ini bertujuan untuk mengkaji hubungan antara self-control dengan adiksi Tiktok pada individu berusia 18-25 tahun yang tergolong sebagai emerging adulthood. Metode yang digunakan adalah penelitian kuantitatif dengan teknik purposive sampling. Data diperoleh dari 200 partisipan yang berdomisili di Jabodetabek melalui pengisian kuesioner daring menggunakan alat ukur Brief Self-Control Scale (BSCS) dan adaptasi Bergen Social Media Addiction Scale (BSMAS) untuk mengukur adiksi Tiktok. Hasil analisis menunjukkan terdapat hubungan negatif yang signifikan antara self-control dan adiksi Tiktok (r = ?0,806; p < 0,05), artinya tingkat self-control yang lebih tinggi berhubungan dengan kecenderungan adiksi Tiktok yang lebih rendah. Dimensi inhibisi dan inisiasi dalam self-control masing-masing berkontribusi secara signifikan terhadap penurunan adiksi Tiktok dengan nilai korelasi r = ?0,793 dan r = ?0,761. Penelitian ini menegaskan pentingnya self-control dalam mengurangi risiko adiksi media sosial, khususnya Tiktok, pada emerging adulthood.
A PERCEPÇÃO DOS ALUNOS DE CIÊNCIAS CONTÁBEIS ACERCA DO IMPORTÂNCIA DA CONTABILIDADE PÚBLICA NO GERENCIAMENTO DE EMPRESAS PÚBLICAS
Authors: Souza Karina Santos de , Alves Adenes Teixeira , Pereira Bartolomeu Miranda , Carmo Filho Manoel Martins do , Negreiros Miguel Carlos Viana
Published: December 2024

Inicialmente, o artigo trouxe a evolução histórica da contabilidade pública desde os primeiros indícios em 1808 até as regulamentações mais recentes, como a Lei de Responsabilidade Fiscal e a Lei das Estatais. A contabilidade pública é apresentada como um ramo crucial da ciência contábil, responsável por registrar, controlar e demonstrar a execução dos orçamentos públicos e o patrimônio, garantindo transparência e accountability na gestão dos recursos públicos. O objetivo da pesquisa é evidenciar a percepção dos alunos de ciências contábeis acerca da importância do papel da contabilidade pública no gerenciamento de empresas vinculadas ao governo federal, através da conceituação da contabilidade pública, bem como mostrar as consequências de um mau gerenciamento das empresas sem o auxílio da contabilidade e observar e analisar através de dados gráficos a opinião dos alunos. O papel do contador público é explorado, enfatizando sua responsabilidade na gestão patrimonial, conformidade legal e apresentação de informações contábeis claras e precisas. A metodologia adotada envolveu o método dedutivo e uma revisão bibliográfica detalhada, que inclui análise e interpretação de diversas fontes para investigar o papel da contabilidade pública na gestão financeira das empresas vinculadas ao governo federal. Espera-se que este estudo contribua para o entendimento da importância da contabilidade pública na eficácia da gestão das empresas públicas, promovendo maior transparência, accountability e eficiência na administração dos recursos públicos no Brasil.
A INTELIGÊNCIA ARTIFICIAL E AS QUESTÕES ÉTICAS NO MERCADO DE TRABALHO
Authors: Mainardi Fernando Henrique Barros , Mendes Ijosiel , Oliveira Elimeire Alves de , Silva Suéllen Danúbia da , Marsoli Glaucimarcos Fakine , Roberto Tiago Moreno Lopes , Pereira Jairo Antonio Bertelli Francisco Gabaldi
Published: December 2024

A Inteligência Artificial (IA) tornou-se um elemento constante nas atividades diárias, com tecnologias baseadas em IA sendo utilizadas em situações comuns e gerando expectativas de melhorias em produtos e serviços. O rápido avanço das tecnologias de IA, como extração, armazenamento, transmissão e processamento de dados, levou ao surgimento do big data, que demanda ferramentas avançadas para extração de informações valiosas. A IA tornou-se um centro de pesquisa, integrando produtos e serviços, gerando benefícios sociais e econômicos. No entanto, seu impacto no mercado de trabalho é um grande desafio, pois algumas profissões podem desaparecer à medida que novas responsabilidades surgem. A IA também pode reduzir a exposição das pessoas a atividades repetitivas e repetitivas, reduzindo o tempo de trabalho e proporcionando mais tempo para a família, amigos e lazer. Para garantir uma IA confiável e responsável, ela deve aderir às leis, seguir valores éticos e ser técnica e socialmente robusta. A IA deve abordar questões como justiça, transparência e privacidade e regulamentação para reduzir riscos. A IA deve promover uma melhor qualidade de vida para todos, de forma justa e inclusiva.
O PAPEL DA TECNOLOGIA ASSISTIVA NO PROCESSO DE INCLUSÃO EDUCACIONAL POSSIBILIDADES E LIMITAÇÕES
Authors: Ribeiro Gleick Cruz , Ferreira Elza Mote , Masioli Karla Zumerle , Rego Marinete da Silva , Silva Mirtes Rejane Carneiro , Santos Silvana Maria Aparecida Viana , Bianchini Tatiani Bonfim , Silva Vanessa Nogueira da
Published: December 2024

Esta pesquisa examina o papel fundamental da tecnologia assistiva (TA) como instrumento facilitador no processo de inclusão educacional, analisando suas possibilidades e limitações no contexto escolar brasileiro. O problema central investigado foi compreender como as tecnologias assistivas podem contribuir efetivamente para a inclusão educacional, considerando os desafios e potencialidades de sua implementação. Utilizou-se metodologia de revisão bibliográfica sistemática, com abordagem qualitativa, incluindo análise de publicações científicas entre 2014 e 2024 em bases de dados acadêmicas reconhecidas. Os resultados evidenciaram que a tecnologia assistiva, quando adequadamente implementada, proporciona autonomia e independência aos estudantes com necessidades especiais, facilitando seu processo de aprendizagem e participação social. Contudo, identificaram-se barreiras significativas como: alto custo dos dispositivos, carência de profissionais capacitados e infraestrutura inadequada nas escolas. A pesquisa destacou a necessidade de políticas públicas mais efetivas para ampliar o acesso às tecnologias assistivas, além de investimentos em formação continuada dos educadores. As considerações finais apontaram que, apesar dos desafios, a tecnologia assistiva representa um recurso transformador para a educação inclusiva, demandando uma abordagem sistêmica que envolva gestores, educadores, famílias e toda comunidade escolar para sua efetiva implementação.
SISTEM INFORMASI MANAJEMEN ASET KATEGORI ELEKTRONIK MENGGUNAKAN METODE AGILE
Authors: Tranhuji Gumbara  , M. Zakki Abdillah
Published: December 2024

Electronic asset management is important to increase operational efficiency and minimize the risk of loss or damage to goods that are company assets. Developed system for managing inventory data, maintenance and asset reporting. The development process follows the Agile stages, starting from gathering requirements through interviews and surveys with users. Next, the interface and system features are designed, as well as iterative testing to ensure the system meets user expectations. The result of this research is an information system that can manage electronic asset data effectively, increase information accuracy, and speed up the decision-making process. It is hoped that the implementation of this system can make a significant contribution to asset management in the organization and increase transparency and accountability in the use of resources.
Penggunaan Realitas Augmented untuk Pembuatan Prototipe Desain Produk: Studi Kasus pada Pengembangan Aplikasi Mobile
Authors: Setiyo Prihatmoko  , Sumaryanto Sumaryanto , Jarot Dian Susatyono
Published: December 2024

Penelitian ini mengeksplorasi penggunaan Realitas Augmented (AR) dalam pembuatan prototipe desain produk, dengan fokus pada aplikasi mobile untuk e-commerce. Tujuan penelitian ini adalah untuk mengevaluasi bagaimana AR dapat meningkatkan proses prototyping dalam desain produk, meningkatkan efisiensi, dan memfasilitasi interaksi lebih baik antara desainer dan pengguna akhir. Metode penelitian melibatkan pengembangan prototipe aplikasi mobile dengan AR dan pengujian dengan pengguna akhir. Hasil menunjukkan bahwa AR mempercepat proses desain, meningkatkan akurasi visualisasi, dan memperbaiki komunikasi desain. Penelitian ini memberikan wawasan tentang manfaat dan tantangan penggunaan AR dalam desain produk.
anime Pengaruh Anime (kartun Jepang) Terhadap Perilaku Kekarasan Pada Remaja
Authors: Nurmana Ayyub , Florencia Irene Yuliani
Published: December 2024

Anime, salah satu bentuk animasi Jepang, umumnya dikenal karena visualnya yang dinamis yang menampilkan karakter dalam beragam latar dan narasi. Gaya unik ini sering kali menekankan karya seni yang dinamis dan penceritaan yang kreatif, yang membedakannya dari bentuk animasi lainnya. Selain itu, anime telah menjadi simbol budaya Jepang, menarik khalayak luas baik di dalam negeri maupun internasional karena beragam genre dan tema. Anime ini ditonton oleh berbagai kalangan mulai dari anak-anak hingga orang dewasa berdasarkan genre yang berbeda-beda. Penelitian pengaruh anime/kartun Jepang terhadap perilaku bertujuan untuk melihat pengaruh anime/kartun Jepang terhadap perilaku kekerasan. Meningkatnya kasus kekerasan dan penindasan berdasarkan kasus kekerasan. Ada yang beranggapan paparan kekerasan yang dilakukan remaja dengan tayangan seperti anime menjadi penyebabnya. Namun anime kekerasan tidak menyajikan adegan peristiwa melainkan menyisipkan nilai-nilai positif yang perlu ditiru oleh seseorang.
Molecular, morphological and chemical characterization of a poorly known lichen: the case of Ramalina wirthii (Ramalinaceae, Ascomycota)
Authors: Blázquez Miguel , Barriopedro Peréz Adrián , Pérez-Vargas Israel
Published: December 2024

The ascomycete genus Ramalina is one of the most remarkable examples of insular diversity and endemicity in lichen-forming fungi, as nearly half the species present in the Macaronesian region are endemic. Among the five archipelagos of the region, Azores is the one that hosts less endemic species: the fertile R. azorica and the sterile R. wirthii, both only known from the eastern islands of the archipelago. In a recent trip to the westernmost island of the Azores (Flores) we have discovered a population of R. wirthii with fertile thalli. In order to confirm the identification of these specimens, we conducted a molecular phylogenetic study based on the ITS region. In addition, we studied their morphology using 30 traits previously reported in the literature as relevant for the genus, and their secondary chemistry by thin layer chromatography. About half the morphological traits were not present in the original description of the species and are reported here for the first time. In addition, the specimens from Flores did not match with eight of the remaining characters. For this reason, they could be confused with other Ramalina species. Morphological and chemical differences with these taxa are discussed.
First record of Plocama brevifolia in Europe (province of Cadiz, Spain) and taxonomic and ecological remarks
Authors: Muñoz-Secilla Felipe , Vega-Pérez Alberto , Devesa Juan A. , Martínez Sagarra Gloria
Published: December 2024

We report the presence of Plocama brevifolia (Rubiaceae) in the southwest of the Iberian Peninsula (province of Cadiz, Spain). This discovery is not only the first record of the species in the Iberian Peninsula, but also in Europe. We provide ecological notes focusing on the conservation risks associated with this area. Some taxonomic remarks are also included based on a review of North African herbarium specimens.
Assessing scientific publications by their impact. A possibility for a more accurate evaluation of researchers
Authors: Loidi Javier
Published: December 2024

The use of metrics in the evaluation of a researcher’s output is now a common practice and has a decisive influence on their career (metricracy). It is widespread to consider the Journal Impact Factor (JIF) as a means of assessing the quality and significance of a paper. It has been discussed that it is appropriate to use a metric that evaluates each paper based on its citations rather than the journal in which it was published. Other parameters such as the number of years since publication, the number of authors and their position in the author list are also discussed and a formula for scoring each published article is proposed.
Desinformação como política
Authors: Dantas de Figueiredo Carolina , Temóteo de Oliveira Neto Otávio
Published: December 2024

A comunicação e seus sistemas são expressão dos processos sociais, políticos e econômicos das sociedades. Em face disto, o presente artigo analisa a ocorrência de desinformação no perfil de Twitter (X) do presidente Jair Bolsonaro com base em uma coleta feita de janeiro a maio de 2020, utilizando-se a Teoria-Ator-Rede como referência. Chegou-se à conclusão, após a análise de mais de 40 postagens que, além de informações não validadas através de fontes e de diversas opiniões, utiliza-se firehosing com o objetivo de mobilizar a opinião pública em torno dos valores compartilhados pelo presidente e seus seguidores, num fenômeno conhecido por câmaras de eco. Mesmo tendo-se passado quatro anos desde a coleta, deve-se considerar que o tensionamento político, que levou à epidemia de desinformação a partir da campanha presidencial de Donald Trump em 2018 permanece igualmente presente no Brasil e no contexto global (tanto que Trump é pré-candidato ao cargo em 2024).
Imagens que transbordam
Authors: Pereira Rômulo Medeiros , Lins Eunice Simões
Published: December 2024

O objetivo do artigo consiste em desenvolver a análise do filme “Tão Sentindo um Cheiro de Queimado?”. Para tal empreitada, buscamos informações sobre uma cultura musical underground que surgiu na Paraíba em meados da década de 1980, realizando a pesquisa histórica no acervo do Arquivo Histórico Waldemar Duarte, localizado na biblioteca do Espaço Cultural em João Pessoa, PB. Nossa pesquisa é descritiva, documental e bibliográfica, oriunda do cruzamento de informações colhidas de periódicos, entrevistas e documentários fílmicos para desenvolver a coleta dos dados. Para a análise das imagens, nos apropriamos do conceito de “tribalismo” de Michel Maffesoli, da teoria do imaginário de Gilbert Durand e de outros conceitos, promovendo diálogos entre eles que nos ajudaram a pensar a representação que constitui o saber fílmico. Como resultado do estudo, buscamos um novo olhar, uma nova forma de enxergar, apreendendo no próprio filme imagens e falas que destacam o movimento, o dinamismo e a força de descolamento que as subjetividades punks e headbangers buscavam expressar, escapando da representação tanto do conhecimento cinematográfico quanto das falas dos cineastas.
Molecular modeling of some commercially available antiviral drugs and their derivatives against SARS-CoV-2 infection
Authors: Arman Mohammad , Alam Safaet , Maruf Rifat A. , Shams Ziaus , Islam Mohammad N.
Published: December 2024

Numerous prior studies have identified therapeutic targets that could effectively combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including the angiotensin-converting enzyme 2 (ACE2) receptor, RNA-dependent RNA polymerase (RdRp), and Main protease (Mpro). In parallel, antiviral compounds like abacavir, acyclovir, adefovir, amantadine, amprenavir, darunavir, didanosine, oseltamivir, penciclovir, and tenofovir are under investigation for their potential in drug repurposing to address this infection. The aim of the study was to determine the effect of modifying the functional groups of the aforementioned antivirals in silico. Using the genetic optimization for ligand docking algorithm on software Maestro (version 11.1), the modified antivirals were docked onto ACE2 receptor, RdRp, and Mpro. Using QuickProp (Maestro v11.1), PASS (prediction of activity spectra for the substances), and altogether with SwissADME, the ADMET (absorption, distribution, metabolism, excretion, and toxicity) of the modified antivirals, as well as their bioavailability and the predicted activity spectra, were determined.  Discovery studio software was used to undertake post-docking analysis. Among the 10 antivirals, N(CH3)2 derivative of darunavir, N(CH3)2 derivative of amprenavir and NCH3 derivative of darunavir exhibited best binding affinities with ACE2 receptor (docking scores: -10.333, -9.527 and -9.695 kJ/mol, respectively). Moreover, NCH3 derivative of abacavir (-6.506 kJ/mol), NO2 derivative of didanosine (-6.877 kJ/mol), NCH3 derivative of darunavir (-7.618 kJ/mol) exerted promising affinity to Mpro. In conclusion, the results of the in silico screenings can serve as a useful information for future experimental works.
Prevalence and associated risk factors of musculoskeletal disorders among information technology (IT) professionals: A systematic review
Authors: Prasetya Tofan AE. , Mamun Abdullah A. , Rahmania Aisy , Ahmed Mobashwer , Uddin Abu SMS. , Nilamsari Neffrety , Wardani Ratnaningtyas WK.
Published: December 2024

Musculoskeletal disorders (MSDs) are a growing concern among information technology (IT) professionals. Understanding the specific risk factors associated with MSDs among employers, occupational health practitioners, and IT professionals may reveal effective preventive measures. The aim of this study was to examine the prevalence and identify the risk factors associated with MSDs among IT professionals. A comprehensive literature search was conducted on several databases, including PubMed, Scopus, ScienceDirect, ProQuest, Online Library Wiley, Springer, Web of Science, and manual searches to identify relevant studies published between 2013 and 2023. The search strategy employed appropriate keywords related to IT professionals, musculoskeletal disorders, prevalence, and risk factors. Two reviewers independently assessed each article using PRISMA guidelines and the Joanna Briggs Institute’s (JBI) Critical Appraisal Checklist for Prevalence Data. Data extraction was performed, and a narrative synthesis was conducted to summarize the findings. Our search yielded a total of 1159 records, with 13 studies finally included in this review. The selected studies were from several countries and contained a total of 4632 participants. The prevalence of MSDs was reported with a maximum rate of 89% and a minimum rate of 20%, reflecting the overall percentage of affected individuals and including data on specific body areas affected. Identified risk factors from the selected studies include work duration, experience, sex, strenuous back positions, smoking, physical inactivity, MSD history, uncomfortable workstation setting, mental stress, insufficient sleep, body posture, exercise status, alcohol consumption, prolonged sitting, workspace, job demands, overexertion, breaks during work, and excessive usage of smartphones.
Secretome from hypoxic mesenchymal stem cells as a potential therapy for ischemic stroke: Investigations on VEGF and GFAP expression
Authors: Silvana Sisca , Japardi Iskandar , Rusda Muhammad , Daulay Rini S. , Putra Agung , Mangunatmadja Irawan , Darlan Dewi M. , Sofyani Sri , Andreas Yana
Published: December 2024

Ischemic stroke is a sudden onset of neurological deficit resulting from a blockage in cerebral blood vessels, which can lead to brain tissue damage, chronic disability, and increased risk of mortality. Secretome from hypoxic mesenchymal stem cells (SH-MSC) is a potential therapy to improve neurological deficit by increasing the expression of vascular endothelial growth factor (VEGF) and reducing glial fibrillary acidic protein (GFAP). These effects can reduce the infarction area of ischemic stroke. Therefore, the aim of this study was to analyze the effect of 150 μL and 300 μL SH-MSC injection on VEGF and GFAP expression as well as the improvement of infarction area in ischemic stroke animal model. A post-test-only experimental design with consecutive sampling was used, with Rattus norvegicus as subjects. Stromal mesenchymal stem cells (S-MSCs) were isolated from the umbilical cords of rats at 21 days of gestation. Secretome production by the S-MSCs was induced under a hypoxic condition, and subsequently isolated. The resultant secretome was administered to rats subjected to middle cerebral artery occlusion (MCAO) at doses of 150 μL (P1 group) and 300 μL (P2 group). The results showed that the infarction area was reduced in P1 (p<0.001) and P2 groups (p<0.001). SH-MSC at a dose of 300 μL increased the expression of VEGF (p=0.028) and reduced the expression of GFAP (p=0.001). In conclusion, secretome from hypoxic S-MSC could potentially improve ischemic stroke by upregulating VEGF expression and downregulating GFAP expression.
Comprehensive in silico analysis of single nucleotide polymorphism and molecular dynamics simulation of human GATA6 protein in ventricular septal defect
Authors: Hidayat Taufiq , Irwanto Irwanto , Rohman Ali , Muhyiddin Afrizal AA. , Putri Safira NA. , Kurniawan Dedy B. , Syaban Mokhamad FR. , Firdaus Theakirana , Rahman Mahrus A. , Utamayasa I KA.
Published: December 2024

Congenital heart disease (CHD) represents nearly one-third of congenital birth defects annually, with ventricular septal defect (VSD) being the most common type. The aim of this study was to explore the role of specific GATA binding protein 6 gene (GATA6) mutations as a potential etiological factor in the development of VSD through an in silico approach. Data were collected from the human gene databases: DisGeNET and GeneCards, with protein-protein interaction networks constructed via STRING and Cytoscape. Gene ontology and pathway enrichment analyses were conducted using DAVID, with data analysis in R with significance set at FDR p<0.05. Target single nucleotide polymorphisms (SNPs) of GATA6 were obtained from NCBI dbSNP, and non-synonymous single nucleotide polymorphism (nsSNP) effects were predicted using SIFT, PolyPhen-2, I-Mutant 2.0, Fathmm, MutPred 2.0, SNP&GO, and PON-P2. Conserved regions of GATA6 were analyzed using ConSurf, with functional classification, variant conservation, and stability changes evaluated in Google Colab. Multiple sequence alignment was performed using ClustalW. Mutation modeling and molecular dynamics analysis, using GROMACS, revealed that among 87 intersecting genes, 16 proteins were interconnected with GATA6, showing a centrality value of 0.4378. Gene ontology analysis highlighted atrioventricular canal development, protein-DNA complexes, and transcription factor regulation as key processes for cardiac development, especially in the ventricular septum. NsSNP and molecular dynamics analyses identified rs387906818 and rs387906820 as having the highest pathogenic potential for VSD due to amino acid structural changes.
Global prevalence and contributing factors of transplant renal artery stenosis in renal transplant recipients: A systematic review and meta-analysis
Authors: Tamara Fredo , Fajar Jonny K. , Gersom Camoya , Wicaksono Ramadi S. , Tupamahu Alvira  R. , Huda Fariz N. , Sari Fitria R. , Dela Jamaludin A. , Putri Irawati E. , Sutrisno Muhammad A. , Putra Riyantono , Dwinata Michael , Friatna Yudha , Albaar Thoha M. , Susanto Agung , Dewi Ratih TK. , Suseno Aryo , Samsu Nur
Published: December 2024

Transplant renal artery stenosis (TRAS) is a serious complication of renal transplantation, with its prevalence and associated factors remaining inconclusive. The aim of this study was to assess the global prevalence and risk factors associated with TRAS incidence in renal transplant recipients. We conducted a meta-analysis by collecting data on the prevalence and factors associated with TRAS from articles in Scopus, Embase, and PubMed. The prevalence of TRAS was determined using a single-arm meta-analysis. The factors associated with TRAS were determined using Mantel-Haenszel analysis or inverse variance analysis. Out of 28,599 articles from the searches, 31 of them were included in the analysis. The global prevalence of TRAS was 6% among renal transplant recipients. Diabetes mellitus, hypertension, longer duration of dialysis before transplant, deceased donor, acute rejection, delayed graft function, longer cold ischemic time, and prolonged peak systolic velocity were associated with an increased risk of TRAS. Age, gender, peripheral artery disease (PAD) comorbidity, causes of end-stage renal disease (ESRD), previous dialysis modality, and cytomegalovirus infection were not associated with TRAS incidence. In conclusion, the global prevalence of TRAS in renal transplant recipients is relatively high, and some of the contributing factors to the development of TRAS are preventable. These findings could serve as a guideline for informing the management of TRAS in the future.
Promising candidate drug target genes for repurposing in cervical cancer: A bioinformatics-based approach
Authors: Pratiwi Nurfi , Ulfah Aida J. , Rachmadina Rachmadina , Irham Lalu M. , Afief Arief R. , Adikusuma Wirawan , Darmawi Darmawi , Kemal Rahmat A. , Rangkuti Ina F. , Savira Maya
Published: December 2024

Cervical cancer is the fourth most common cancer among women globally, and studies have shown that genetic variants play a significant role in its development. A variety of germline and somatic mutations are associated with cervical cancer. However, genomic data derived from these mutations have not been extensively utilized for the development of repurposed drugs for cervical cancer. The objective of this study was to identify novel potential drugs that could be repurposed for cervical cancer treatment through a bioinformatics approach. A comprehensive genomic and bioinformatics database integration strategy was employed to identify potential drug target genes for cervical cancer. Using the GWAS and PheWAS databases, a total of 232 genes associated with cervical cancer were identified. These pharmacological target genes were further refined by applying a biological threshold of six functional annotations. The drug target genes were then cross-referenced with cancer treatment candidates using the DrugBank database. Among the identified genes, LTA, TNFRSF1A, PRKCZ, PDE4B, and PARP were highlighted as promising targets for repurposed drugs. Notably, these five target genes overlapped with 12 drugs that could potentially be repurposed for cervical cancer treatment. Among these, talazoparib, a potent PARP inhibitor, emerged as a particularly promising candidate. Talazoparib is currently being investigated for safety and tolerability in other cancers but has not yet been studied in the context of cervical cancer. Further clinical trials are necessary to validate this finding and explore its potential as a repurposed drug for cervical cancer.
ACE inhibitors versus angiotensin receptor-neprilysin inhibitors for HFrEF management: A prospective cohort study from Indonesia
Authors: Heriansyah Teuku , Lestari Nova D. , Hadi Tjut F. , Novia Rizki , Munawarah Iffah , Taufiqurrahman Taufiqurrahman , Yuvhendmindo Shahcoga L. , Bashori Ahmad A.
Published: December 2024

Previous studies have reported that angiotensin receptor-neprilysin inhibitors (ARNI) are superior to angiotensin-converting enzyme inhibitors (ACEI) in treating heart failure with reduced ejection fraction (HFrEF). Unfortunately, previously published studies predominantly focused on Western populations, while the data remains insufficient in developing countries. The aim of this study was to compare the efficacies of ARNI and ACEI on patients with HFrEF in Indonesia. A prospective cohort study was conducted among heart failure patients at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Both ACEI and ARNI each consisted of 40 subjects receiving standard treatment for heart failure. Left ventricular ejection fraction (LVEF), quality of life (QoL), suppression of tumorigenicity 2 (ST2), and troponin T were measured upon admission and at the end of the follow-up. In addition, the occurrence of major adverse cardiac events (MACE) was observed during 6 months of follow-up. Paired t-test was used to compare the outcomes of ACEI and ARNI. The results revealed that KKCQ score and LVEF were improved in both ARNI and ACEI groups (each with p<0.001). A higher KCCQ overall score was observed in the ARNI group in contrast to the ACEI group (p=0.01). ARNI demonstrated superior results in improving the ejection fraction as compared with ACEI (p=0.001). Troponin T and ST2 levels exhibited no significant difference between the two groups (p=0.07 and 0.286, respectively). MACE-associated mortality (p=0.696) and rehospitalization (p=0.955) were identical between both groups. In conclusion, ARNI was more efficacious than ACEI in improving the quality of life and left ventricular ejection fraction of patients with HFrEF. However, the efficacy was not significantly different in reducing the risk of MACE.
Estimate the relationship between CXCR4-SDF-1 axis and inhibitory molecules (CTLA4 and PD-1) in patients with colon cancer
Authors: Abdul-Huseen Suhad D. , Alabassi Hazima M.
Published: December 2024

Colon neoplasia is one of the major malignancies in industrialized countries due to their Western-style food habits. It accounts for more than 50% of the population developing adenomatous polyps by the age of 70 years, but 10% of cancers in developed countries. The aim of this study was to evaluate the pathological role of the C-X-C chemokine receptor type 4/stromal-derived factor 1 axis (CXCR4-SDF-1  axis), and the inhibitory molecules PD-1 and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) in postoperative colon cancer patients undergoing treatment with chemotherapy (oxaliplatin and capecitabine) and estimate the correlation between these studied factors to deeply understand the basic mechanisms and potential diagnostic or therapeutic effects. The study involved 90 patients, including 50 colon cancer patients (male and female, aged 35–65) diagnosed by oncologists at Al-Ramadi Hospital, Ramadi, Iraq. All patients underwent surgical resection and received four cycles of chemotherapy with oxaliplatin (85 mg every 21 days) and capecitabine (6 grams daily for 21 days). Additionally, 40 age- and sex-matched individuals served as the control group. For each participant, CXCR4 and SDF-1 levels were measured using ELISA and the gene expression of CTLA-4 and PD-1 were measured using RT-PCR. The colon cancer patient group showed significantly lower levels of CXCR4 and SDF-1 compared to control groups (0.163±0.012 vs 0.376±0.025 pg/mL and 0.376±0.025 vs 0.699±0.110 pg/mL, respectively, both had p=0.001). Moreover, the colon cancer patient group had significantly lower expression of PD-1 and CTLA4 compared to control group (0.102±0.029-fold vs 1.199±0.391-fold, p=0.02; and 0.302±0.140-fold vs 1.441±0.334-fold, p=0.008, respectively). In conclusion, the results suggest that CXCR4 and SDF-1 appear promising as diagnostic markers for distinguishing colon cancer patients from healthy conditions.