bluuebunny/crossref_metadata_2025 huggingface dataset:
P090 Anal Fistula Cancer of Luminal Origin Associated With Crohn's Disease: A Case Report
Authors: Shinozaki Masaru , Tanaka Torao , Takane Kiyoko , Ota Yasunori , Yazawa Kentaro , Tateno Yoko , Furukawa Yoichi
Published: December 2019

CASE:

Recent studies have shown that the risk of anal fistula cancer, as well as colorectal cancer, is increased in patients with Crohn's disease (CD) compared with that in the general population. The prognosis of patients with anal fistula cancer associated with CD is generally poor, and its natural course has not been clarified yet. Herein, we report a case of anal fistula cancer and rectal tumor associated with CD, which shared the same genetic mutations. A Japanese man was diagnosed with CD at the age of 25 years. When he was 38 years old, he underwent a subtotal colectomy, ileo-sigmoid colonic anastomosis for entero-entero fistula, and seton drainage for anal fistula. He received maintenance therapy consisting of azathioprine and infliximab. Additionally, annual surveillance colonoscopy had been performed. When he was 44 years old, a small reddish, slightly depressed area very close to the dentate line was detected. Although the lesion did not appear to change in size for 2 years, it got larger, and the surface pattern was indicative of neoplasm, when he was 47 years old. The tumor was biopsied for the first time, which revealed high-grade dysplasia. The patient agreed to undergo excisional biopsy under spinal anesthesia. The operation was performed as follows: after the tumor was excised, we changed our gloves and instruments and sterilized the surrounding area with povidone iodine to avoid contamination. We explored the fistula with curettage, since its primary orifice was located very close to the tumor. We also removed the surrounding mucosa separately. The biopsy specimens were submitted for pathological review. The tumor revealed high-grade dysplasia, which was restricted to the mucosal layer, and the specimen from the anal fistula also showed high-grade dysplasia. Computed tomography or magnetic resonance imaging scans revealed no evidence of malignancy. Therefore, we recommended him to undergo abdominoperineal resection to check for possible cancer at the anal fistula, for which the patient agreed. The specimen of the abdominoperineal resection showed that the remaining cancer extended to the anal fistula. The cancer spread infiltratively, spanning approximately 1 cm × 2 cm without mass formation. The histology findings revealed well-differentiated adenocarcinoma and mucinous adenocarcinoma. We performed a genetic analysis of the polypoid tumor and the anal fistula cancer. The results showed that the same somatic mutation, c.1015_1016insCTTCG, in the TP53 gene was identified in both tumors but not in the paired non-cancerous tissue, suggesting that the tumors originated from the same neoplastic cell. The morphological progression detected through the surveillance colonoscopy suggested that the polypoid tumor was the primary lesion, and the anal fistula cancer was a spread or metastasis of the polypoid lesion. Therefore, some anal fistula cancers may be of luminal origin.
P091 Factors Predicting Compliance With Passive and Active Monitoring in Inflammatory Bowel Disease Patients
Authors: Singer Jorie , Rai Victoria , Sossenheimer Philip , Karpin Jordan , Rodriguez Tina , Yi Yangtian , Yvellez Olivia , Rubin David
Published: December 2019

BACKGROUND:

Updated goals of management of IBD patients include monitoring disease activity, yet compliance with such strategies is poorly studied. We are performing a multi-year study of patients with active and quiescent IBD to assess the utility of a wearable, continuously active biosensor and validating disease activity with scheduled stool (calprotectin) and serum (CRP) testing. This study assessed compliance with these passive and active monitoring strategies.

METHODS:

Patients with diagnosed IBD were recruited for a prospective study using a biosensor (Fitbit Alta HR, San Francisco, CA) and mobile application (Litmus Health, Austin, TX). Each patient was instructed to wear a biosensor for a one-year period with stool sample drop-offs and blood draws for the first 6 months. The biosensor collected step count, sleep time, and heart rate during the study. Compliance was calculated as the number of days of heart rate, step count, and sleep data received over the duration of the study measured in days. Compliance was defined as ≥80% data collection in the time studied. A t-test was performed to determine the significant difference (P < 0.05) in compliance based on age, sex, disease activity, and body mass index (BMI); and between day time and night time wear.

RESULTS:

A total of 40 patients were analyzed; 23 men (57.5%), 24 with ulcerative colitis (60%), and 20 in remission (50%). 28 patients were <50 years of age (70%). The average BMI was 26.5 kg/m2. Overall, there was a 78% biosensor compliance rate among IBD patients. 45% of patients in clinical remission were compliant in stool drop-offs, while 60% of patients with clinically active disease were compliant in stool drop-offs (P > 0.05; 95% CI: -14.8 to 41.39). There were significant differences between biosensor compliance at night (57%) and day (98%) (P < 0.01; 95% CI: 0.31 to 0.5) and active disease (P < 0.01; 95% CI: -1.13 to -0.80). There was no significant difference in compliance and sex (P > 0.05; 95% CI: -0.53 to 0.11), age (P > 0.05; 95% CI: -11.14 to 7.84), and BMI (P > 0.05; 95% CI: -3.62 to 5.57). There were insufficient data to analyze compliance in answering questionnaires.

CONCLUSION(S):

In this study, patients were more compliant wearing the biosensor during the day than during the night and were more compliant if they had clinically active disease. In future studies, it will be important to provide an incentive and intervention to promote compliance in both active and passive monitoring strategies.
P096 Cerebral Venous Thrombosis as a Complication of Crohn's Disease
Authors: Tatineni Shilpa , Burch Jacob , Al-Abcha Abdullah , Cherian John , Laird-Fick Heather
Published: December 2019

BACKGROUND:

Extra-intestinal complications of inflammatory bowel disease are extensive; one well-known but rare complication is the development of thrombo-embolism. Most frequently reported events involve pulmonary or peripheral venous thromboses. We report an unusual case of cerebral venous thrombosis in a female patient with Crohn’s disease.

CASE:

A 52-year-old female with past medical history significant for Crohn’s disease and migraines presented to the hospital with a chief complaint of sudden onset numbness and weakness in her right upper extremity. On the day of admission, she awoke at approximately 5AM with a 10/10 throbbing, frontal headache associated with nausea & photophobia. She went back to sleep and awoke 3 hours later with arm weakness. CT brain without contrast showed an extensive thrombosis of the superior sagittal sinus and bilateral cortical veins with associated intraparenchymal hemorrhage of the left frontal lobe. CT angiography (CTA), magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) of the brain, performed subsequently, re-demonstrated the prominent sagittal sinus thrombosis with involvement of the right transverse and sigmoid sinuses and mild propagation of the thrombus into the straight sinus. She was started on IV heparin and neurosurgery was consulted. Her handgrip strength slowly improved to 4/5. Inflammatory pro-markers, ESR and CRP were elevated, supporting active Crohn’s inflammation. Genetic testing for inherited thrombophilia were negative. She was ultimately discharged home with warfarin.

DISCUSSION:

Arterial and venous thrombo-embolic events are well documented and sometimes life-threatening complications of inflammatory bowel disease. Cerebral venous thrombosis has been reported rarely, but more often in association with ulcerative colitis than Crohn’s disease. Although the exact mechanism is unknown, the synergistic effects of an inflammatory state combined with transient elevation of coagulation factor levels, endothelial vascular activation, acquired natural anticoagulant deficiencies, increased platelet activation, and increased platelet aggregation have been shown to contribute to the prothrombotic state. Overall, patients with IBD have an approximately 2-fold increased risk for venous thrombo-embolism than the general population (RR, 1.96; 95% CI, 1.67-2.30), and account for 1.6% of all patients with central venous thrombosis. Early recognition and high suspicion of this condition for patients with IBD can help decrease mortality and prevent devastating complications such as hemiparesis, seizures, hydrocephalus, visual loss and dural arteriovenous fistulas. The optimal duration of anticoagulation and the risk for recurrent thrombosis are unclear in this population. Treatment merits careful coordination between gastroenterology, hematology, and neurology.
P111 The Efficacy of Early Treatment in Immune Checkpoint Inhibitor-Related Colitis: Clinical Outcomes in a Retrospective Case Series
Authors: Yutsudo Kazuki , Tanaka Akihito , Komaki Yuga , Iwaya Hiromichi , Arima Shiho , Sasaki Fumisato , Tanoue Shiroh , Hashimoto Shinichi , Kanmura Shuji , Ido Akio
Published: December 2019

BACKGROUND:

New immunotherapy using immune checkpoint inhibitors plays a critical role in cancer treatment. Immune checkpoint inhibitor-related colitis (irAE-colitis) occurs in approximately 1–20% of cancer patients treated with immune checkpoint inhibitors. There are limited data on the outcomes of optimal treatment in patients with irAE-colitis. The aim of this report was to clarify treatment outcomes for patients with irAE-colitis in our facilities.

METHODS:

Of 676 patients who received immune checkpoint inhibitors at our hospital and related facilities, nine patients who developed irAE-colitis were included. We defined effectiveness as follows: a decrease of 3 points or more in a Mayo endoscopic sub-score, 0 or 1 points in a rectal bleeding score and 2 points or more in a Mayo clinical score.

RESULTS:

The male-to-female ratio was five to four. There were five cases of lung cancer, one case of renal cancer, one of head and neck cancer, one of melanoma, and one of gastric cancer. The immune checkpoint inhibitors pembrolizumab and nivolumab, which are anti-PD-1 antibodies, were used in six and three cases, respectively. The drugs used after onset are as follows. One case was mesalazine, six were steroids, one was infliximab, and one was cyclosporine. The effective rate of steroids was 84% (5/6 cases), of which two cases relapsed during steroid tapering. However, both cases improved with steroid re-administration. For one case where steroids were ineffective, we used infliximab. Although the patient’s condition improved temporarily, we encountered secondary failure and changed to cyclosporine, which was effective. One case died before treatment intervention due to severe diarrhea. Immune checkpoint inhibitors were discontinued in all cases. At the time of writing, six patients are still alive after improvement of abdominal symptoms.

CONCLUSION(S):

Steroid therapy was quite effective for the treatment of irAE-colitis, although early relapse occurred in some cases. Prospective studies are required to define the optimal management of irAE-colitis in order to maintain positive long-term outcomes.
O Mundo das Mídias Sociais Segundo os Brasileiros: uma análise da presença das mídias sociais em um programa de infotenimento
Authors: Reis Carlos Eduardo dos
Published: December 2019

Este artigo efetua uma análise da influência das mídias sociais na produção do programa de TV O Mundo Segundo os Brasileiros (Brasil, TV Bandeirantes). Esta produção pertencente ao gênero infotenimento, retrata a cultura de uma determinada cidade do ponto de vista de um grupo de brasileiros, de idades e perfis diferentes, que mostram para as câmeras como vivem naquele ambiente. O termo infotenimento deriva da junção entre as palavras informação e entretenimento e é visto cada vez mais nas produções televisivas. Analisamos as mídias sociais (Facebook/Fanpage, Twitter e Instagram) oficiais do programa e percebemos que além da divulgação dos episódios, o processo de recrutamento dos participantes é iniciado por esse meio. O surgimento das novas tecnologias abre novas perspectivas de interação entre produtor e as novas plataformas contribuem para o desenvolvimento do produto, já que os produtores passam a compreender melhor o desejo do mercado. Este estudo é relevante, pois parece ser uma tendência das empresas de comunicação utilizarem cada vez mais as mídias sociais para se relacionarem com o seu público-alvo.
Quem somos? O perfil educacional do formado em Jornalismo na UFMA de Imperatriz (MA)
Authors: Gehlen Marco Antônio , Bueno Thaísa , Paula Vanessa de
Published: December 2019

Considerando que o curso de Jornalismo da Universidade Federal do Maranhão, campus de Imperatriz, completou dez anos em 2016 e está implementando uma nova grade curricular para atender as novas exigências do Ministério da Educação, bem como a ausência de levantamentos sobre o perfil dos profissionais formados na instituição, este estudo objetivou traçar o perfil do formado em Jornalismo de Imperatriz, levantando o que esses pensam acerca de sua formação. Para tanto, desenvolveu-se uma investigação com método quantitativo-descritivo para levantamento e análise de dados a partir da aplicação de um questionário semiestruturado por meio do qual foi possível obter respostas de 88,6% dos formados pretendidos. Tem-se que apenas 176 graduandos se formaram nos dez primeiros anos do curso, uma vez que 520 alunos deveriam ter alcançado a formação até o período 2015.2.O artigo permite compreender informações adicionais sobre perfil dos formados com pistas para os novos rumos do curso.
Produção científica docente: estudo sobre as publicações dos cursos de Jornalismo do Tocantins
Authors: Macedo de Sousa Poliana
Published: December 2019

O presente estudo faz um mapeamento da produção científica dos docentes vinculados aos cursos de Jornalismo no Estado do Tocantins, em três Instituições de Ensino Superior (Universidade Federal do Tocantins - UFT, Centro Universitário Unirg e Ceulp/Ulbra), todos credenciados pelo MEC – Ministério da Educação e que estavam em funcionamento durante os anos de 2006 a 2016. Esse mapeamento foi realizado por meio de análise do Currículo Lattes de cada docente até então vinculado aos cursos. Analisou-se a publicação de artigos em periódicos, livros e/ou capítulos de livros publicados, trabalhos publicados em anais de eventos, resumos publicados em anais de eventos e apresentação de trabalhos em eventos científicos. Com esse mapeamento foi possível identificar o quanto os docentes produziram nesse período e qual o canal de comunicação científico mais utilizado pelos mesmos para a divulgação de sua produção científica.

Palavras-chave: Comunicação Científica. Produção Científica. Jornalismo.
Foreign exchange volatility modeling of Southeast Asian major economies
Authors: Ponziani Regi Muzio
Published: December 2019

This study investigates the exchange rate volatility model in Southeast Asian countries. The countries selected were Indonesia, Malaysia, Thailand, The Philippines, Vietnam, and Singapore. This study aims to model the volatility of the regional currency exchange rate against the international currency, i.e., the US Dollar. The period covered in this study extended from 1 January 2013 until 31 July 2019. These were the daily exchange rates of 7 currencies of Southeast Asian countries. The currency involved were Indonesian Rupiah (IDR), Malaysian Ringgit (MYR), Thai Baht (THB), The Philippine Peso (PHP), Vietnam Dong (VND), and Singaporean Dollar (SGD). All currencies were measured in the exchange rate against the US Dollar (USD). The result indicated that PARCH model is the best method to explain the movement of MYR, VND, and SGD. GARCH can model THB and PHP. Only IDR that has volatility explainable by TARCH.
Perfis de envolvimento relativo do pai e ajustamento social de crianças em jardim-de-infância
Authors: Amaral Rita , Monteiro Lígia , Santos Carolina
Published: December 2019

O presente estudo teve como objetivo identificar perfis de envolvimento relativo do pai, em diversas atividades relacionadas com o dia-a-dia da criança (cuidados e socialização), testando posteriormente se existiam diferenças, em função dos mesmos, para o ajustamento social das crianças. Participaram 283 famílias nucleares, com crianças em idade pré-escolar (139 rapazes). Foram identificados dois perfis: Perfil 1 – companheiros de brincadeira e Perfil 2 – cuidadores e companheiros de brincadeira. Os pais no Perfil 2 participavam significativamente mais em todas as atividades analisadas. Encontraram-se, ainda, diferenças em função das habilitações literárias de ambos os cuidadores (mais elevadas no Perfil 2) e das horas de trabalho dos pais (mais elevadas no Perfil 1). Para 94 destas crianças as educadoras descreveram o seu ajustamento social, tendo-se verificado que crianças cujos pais estão mais envolvidos nas atividades de cuidados e de socialização apresentavam valores mais baixos de retraimento social ansioso no grupo de pares. Os resultados sugerem a importância de se considerar quer a mãe, quer o pai, quando se desenham programas de promoção do bem-estar e ajustamento social das crianças.
Las madres y su rol educador: una experiencia de cambio desde la educación popular
Authors: González González Jeison Alexander , González Quecán Sara Alejandra , Quiroga Loaiza Nataly
Published: December 2019

La práctica pedagógica dentro del proyecto de Ámbito Familiar de la SDIS[1] evidenció cómo los beneficiarios están condicionados al consumismo de ayudas sociales, al estancamiento en sus condiciones de vida, alejados de posturas que les permitan superar su vulnerabilidad. Aun así, a partir del desarrollo de encuentros pedagógicos mediados por la pedagogía popular, se construyeron espacios de diálogo y reformulación de saberes, lo que permitió que las madres participantes empoderaran su pensamiento a través de la reflexión constante con el otro. Dicha interacción fomentó el autoconocimiento de realidades, para que se reestructuraran y se construyeran saberes nuevos; además, estimuló un cambio en su condición de vida, las ubicó en una postura crítica, las formó como sujetos de derecho, que no se limitan al consumismo desmesurado, sino que por medio de sus habilidades y destrezas crean herramientas que les permiten surgir como ciudadanas activas, con voz y voto dentro de su vida y la de sus hijos.[1] Secretaría Distrital de Integración Social del Distrito Capital, Bogotá.
La seguridad escolar como problema político
Authors: Carranza Torres Daniel Enrique
Published: December 2019

La seguridad escolar comienza a cobrar relevancia en cuanto problema político a finales de la década de 1980 en Europa, el discurso jurídico internacional impulsa y va definiendo la intervención de la política de seguridad escolar en Latinoamérica a inicios del siglo XXI. En este artículo se presentan las miradas públicas sobre el tema en algunos países, en particular Colombia y México. En el debate sobre la seguridad escolar es necesario tener presente la influencia que ejerce la doctrina de seguridad nacional en el mundo, su posterior desplazamiento a lo urbano o local, lo cual se equipara a la seguridad ciudadana que, influenciada a su vez por el enfoque de derechos humanos, permitirá entender las diferencias entre el paradigma de la seguridad humana y la doctrina de la seguridad nacional; así, se evidencian los desafíos de la seguridad escolar en el campo educativo. El estado del arte permitirá identificar la relevancia de la seguridad escolar para la ciudad de Bogotá, como respuesta integral a las problemáticas de violencia escolar y su configuración como problema político.
Reseña de Escritos: la literatura infantil, los niños y los jóvenes
Authors: Porras Suárez Rafael Andrés
Published: December 2019

Gran parte del ideario del pensamiento filosófico y estético de Walter Benjamin (1892-1940) se valora en la compilación cronológica de Escritos, realizada por Guilio Schiavoni[1]. Desde su compromiso marxista romántico de la formación de una niñez y juventud proletaria, hasta la valoración genuina por los rastros, huellas y silencios de los artefactos culturales de la infancia alemana (juegos, juguetes y libros) imprescindibles para una “arqueología” histórica de la vida social de la cultura burguesa. Filósofo, teórico marxista, crítico cultural y coleccionista apasionado, “culto y feliz”. Benjamin, escrito tras escrito, busca el sentido histórico de la vida moderna y la tradición. [1] Guilio Schiavoni nació en Maiolati Spontini1, Italia (1948). Ha sido ensayista y traductor de la literatura alemana de los siglos XVIII y XX. Numerosas de sus publicaciones se concentran en monografías de los intelectuales, filósofos y literatos judeo-alemanes como Kafka, Freud y Benjamin.
V Coloquio de Infancia. Las palabras, las niñas y los niños: poemas y relatos, canciones y rondas, dibujos y libros
Authors: Bothert Karina Claudia
Published: December 2019

En el segundo semestre del presente año, se llevó a cabo el V Coloquio de Infancia, organizado por el grupo de investigación Lenguaje, Discurso y Saberes; la Cátedra Unesco en Desarrollo del Niño; la Maestría en Infancia y Cultura, y la Especialización en Infancia, Cultura y Desarrollo de la Universidad Distrital Francisco José de Caldas.
Relatos de niños y niñas, y algo más
Authors: Santamaría Valero Flor Alba
Published: December 2019

El camino que he recorrido tras la búsqueda y la comprensión de los relatos infantiles tiene su origen, inicialmente, en mi experiencia como profesorade niños en escuelas públicas de Bogotá y, posteriormente, como docente de la Universidad Distrital Francisco José de Caldas, en campos de formación de maestros y de profesionales para la infancia, a nivel de pregrado y posgrado, así como también de la participación en investigaciones relacionadas con el uso lenguaje en aula de clase. Estos espacios me han permitido tener de cercalas voces de los niños, no solo escolarizados sino también, desde otras dimensiones, como lo es el programa de radio Tripulantes, creado desde la Cátedra Unesco en Desarrollo del Niño2, donde cada sábado salen al aire las voces y creaciones de losniños, que desde una radionave simbólica, vuelan y llegan hasta lugares inimaginados.
Estado del arte y abordaje del concepto de ludificación en el aprendizaje en primera infancia
Authors: Pineda Martínez Edgar Oswaldo , Orozco Pineda Paula Andrea
Published: December 2019

Este artículo inspecciona documentos investigativos sobre ludificación que hayan tenido revisión por concolegas o comités científicos. Se crea un proceso para examinar los efectos de la aplicación de la ludificación según parámetros motivacionales. La revisión de la literatura cubre resultados, variables dependientes (aprendizaje, infancia, motivación, conducta), los contextos de la ludificación y tipos de estudios realizados en diferentes ámbitos. El artículo busca presentar el estado de la investigación actual sobre la ludificación en las infancias en el contexto del idioma español; de igual forma señala lagunas en la literatura existente y analizada. La revisión permitió identificar que esta proporciona efectos positivos y cambios conductuales y motivacionales de los sujetos que son dependientes del contexto en el que es aplicada. Sin embargo, no se encontraron estudios específicos para la primera infancia que puedan dar cuenta del éxito de esta metodología en dicha población.
La infancia soñada: el niño en la perversión pedófila
Authors: Cardona Quitián Herwin Eduardo
Published: December 2019

Los informes del Instituto Nacional de Medicina Legal señalan que la violencia sexual contra los niños va en aumento y los datos muestran que el agresor es casi siempre un familiar. La violencia sexual contra los niños evidencia un comportamiento perverso del adulto que genera interrogantes sobre las razones que motivan su acción. ¿Qué lugar ocupa el niño en la sociedad contemporánea? ¿Por qué los marcos de protección son insuficientes para atender esta problemática? El presente artículo se desprende de la tesis doctoral “Infancias deshabitadas”, desarrollada en el Doctorado en Psicoanálisis de la Universidad de Antioquia. El método es indiciario y el enfoque psicoanalítico. Se presentan adelantos parciales sobre el comportamiento perverso pedófilo. Los hallazgos permiten comprender algunas causas de dicho comportamiento: por un lado, analiza el lugar que ocupa el niño en la economía psíquica de sus padres y, por otro, la relación que establece la sociedad contemporánea con la infancia.
Voces y vivencias infantiles: recorrido comprensivo sobre la niñez y la subjetividad
Authors: Verano Camayo Cristian Andrés
Published: December 2019

Este artículo presenta algunos resultados de una investigación en la cual se propuso interpretar compresivamente narraciones de niñas y niños en edad escolar alrededor de su experiencia vital. Se optó por un enfoque metodológico cualitativo en el que el análisis de experiencias buscó revelar desde los relatos de los niños aspectos y significados entretejidos, reconocidos gracias a una especie de método de rodeo (Arfuch, 2013). El abordaje construido trató de dar cuenta de las visiones y posturas de los niños sobre la infancia, la niñez o la adultez a partir de su carácter singular y la especificidad que adquieren a la hora de comunicar las perspectivas sobre el mundo y sobre su mundo. Los hallazgos y las conclusiones se enfocan en estos aspectos y enfatizan la reivindicación de las posibilidades que brinda la palabra para reconocernos también a partir de lo otro y del Otro.
Experiencias de cuidado institucional: construyendo significados desde la mirada de los niños y las niñas
Authors: Franco Rueda Ana Milena
Published: December 2019

Este artículo busca aproximarse a la experiencia de los niños y niñas que se encuentran en cuidado institucional y presentar algunas reflexiones sobre la inconveniencia de la acogida institucional en los procesos de protección infantil. Se exponen los resultados de un ejercicio de diálogo y observación realizado con un grupo de niños y niñas en cuidado institucional en la ciudad de Bogotá en el que se exploraron los significados construidos en torno al proceso de protección y a la estadía en la institución. Finalmente, se presentan algunas reflexiones sobre la importancia de priorizar intervenciones que promuevan el cuidado familiar y minimicen las experiencias adversas en los casos en los que resulte inevitable la transición por entornos de cuidado institucional.
El uso de la escritura en prácticas digitales infantiles: un estado de la cuestión
Authors: Ruiz Klinge Andrea
Published: December 2019

Este artículo de revisión tiene como finalidad dar a conocer el estado del arte en el campo de las infancias, tecnologías de la información y la comunicación (TIC) y prácticas escriturales a partir de las ideas que se infieren de investigaciones publicadas entre los años de 2004 a 2014. Lo anterior condujo a un análisis de 50 investigaciones presentes a nivel nacional e internacional, que fueron halladas en bases de datos como: Scopus, Redalyc, Proquest, Dialnet y Eric. Continuando, se elaboró una tabla de temáticas, de corte inductivo, en la cual fue registrada la información hallada en cada investigación, ejercicio que tuvo como interés principal observar criterios como la población y su participación en el estudio desarrollado, la concepción de infancias que de ahí se desplegó, el posicionamiento social de la escritura y, finalmente, la trascendencia que se le otorgó a las TIC desde las propuestas pedagógicas.
Experiencia con estocásticos en el segundo grado de educación especial en México
Authors: López-Mojica J. Marcos , Lario Trejo Jesús Antonio , Rivera Abrajan Magdalena
Published: December 2019

En el contexto mexicano la educación especial es una modalidad educativa encargada de atender a niños con necesidades educativas especiales asociadas a una discapacidad. El presente informe muestra resultados de la introducción de conceptos de probabilidad y de estadística (estocásticos) en el aula del segundo grado a niños con discapacidad (8-10 años). El interés se centró en documentar el proceso de enseñanza y analizar los desempeños de los estudiantes ante una situación aleatoria sistemática. Bajo la interrelación de tres elementos teóricos (epistemológico, cognitivo y social), se instrumentó una actividad de enseñanza con hojas de control y guion de observación, para la comprensión de espacio muestra, medida de probabilidad y variable aleatoria. Los resultados conciernen al desarrollo de nociones de estocásticos y el uso de otros conceptos matemáticos. Se concluye necesario e imperante el tratamiento de fenómenos aleatorios en este nivel educativo de manera sistemática para ofrecer una matemática básica integral.
Laboratorio móvil de educación artística: El Bus Arte Rodante. La expresión en movimiento
Authors: Chaparro Gómez Beatriz Eugenia , Bravo Jiménez Edwin Fernando , Becerra Vergara Nataly
Published: December 2019

Este artículo versa sobre el desarrollo del proyecto de investigación encaminado a la creación de un laboratorio móvil de educación artística, portador de insumos y elementos facilitadores de procesos para la experimentación con lenguajes artísticos en espacios comunitarios. Los talleres itinerantes fueron creados con aportes de la pedagogía Waldorf y fueron desarrollados con niños y niñas de un barrio periférico del municipio de Popayán. Se reflexiona sobre la incidencia de esta experiencia en el fortalecimiento de tejidos sociales desde la práctica de educadores artísticos que se reconocen como transformadores sociales.
Subjetivación femenina: una mirada a la niña que me ronda
Authors: Puentes Garzón Erika , Beltrán Junca Mabel Edith , Marroquín Fierro Rafael
Published: December 2019

El presente artículo es producto de una exploración investigativa en curso, adelantada por el semillero de investigación Leidy Tabares (Leta), adscrito a la Licenciatura en Pedagogía Infantil de la Universidad Distrital Francisco José Caldas. Esta investigación pretende describir y analizar el proceso de configuración de las subjetividades de las licenciadas en formación durante su infancia, trabajado con un grupo poblacional que comprende estudiantes entre tercer y octavo nivel, desde el enfoque de género, a partir del relato de vida sobre sus prácticas de crianza y/o socialización, desde las cuales estas (mujeres hoy) fueron integradas y/o constituidas. Se trata de evidenciar las coordenadas discursivas (horizonte de sentido) que enrutaron (condujeron) su edificación subjetiva del hecho (histórico-sociocultural) de ser mujer, como también identificar su posición y/o ubicación particular frente al poder, la autoridad, la sociedad, la feminidad, la masculinidad, la sexualidad, el cuerpo, el conocimiento, etc.
Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene
Authors: Akrom Akrom , Hidayati Titiek , Sagiran Sagiran , Indrayanti Indrayanti
Published: December 2019

Interferon-gamma (IFN-γ) is one of the central cytokines in the anti-carcinogenesis immune response. Black cumin seeds (BCS) have an active content of thymoquinone and unsaturated fatty acids with biological activity as immunomodulators. This study aimed to determine the effect of administration of BCS extract on IFN-γ secretion activity by DMBA-induced SD rat lymphocytes. In vivo experimental study on DMBA-induced SD rats, BCS extract was given with three doses for two weeks before being induced and five weeks during DMBA induction. IFN-γ levels in lymphocyte culture supernatants were determined by the ELISA method. The difference in IFN-γ levels between groups was analyzed by ANOVA test, the significance of 95%. The results showed that administration of BCS extract for 14 days did not affect cellular composition toward the edge of the test animal. BCS extract can increase IFN-γ secretion activity by DMBA-induced SD rat lymphocytes.Keywords: black cumin seed, IFN-γ; DMBA: immunomodulator, carcinogenesis.
A Point of Contact Between the Archives of Pompeius Niger and of Tryphon the Weaver?
Authors: Maravela Anastasia , Mangerud Jens
Published: December 2019

This article argues that the name of the aggresive female character mentioned by the sender of the private letter SB VI 9121 is Seraeus, and proposes further that through her this letter connects the family of the veteran of the Roman army L. Pompeius Niger, to whose archive it belongs, with the family of Tryphon the weaver.
Reuniting the Dossier of Flavius Demetrios, an Aristocrat and Landowner in Late Antique Hermopolite
Authors: Giacometti Dario
Published: December 2019

This article presents new evidence that a certain Demetrios, documented in CPR IX 12-19, where he issues orders for delivery, is identical with the megaloprepestatos comes Flavius Demetrios, who lived in the Hermopolite nome during the early 7th century AD and is known from SPP XX 218, P.Laur. II 26 and CPR IV 106.
Challenges of Korean Immigrant Leadership in the Church
Authors: Choi Hee An
Published: December 2019

The article suggests that the practices of leadership within Korean communal transformational leadership in Korean resistance movements provide a resource for women in the Korean immigrant church. The article addresses the challenges of Korean leadership in immigrant contexts, how immigrant leadership is performed and transformed, and how immigrants have developed and adapted their leadership from a Korean to US context during the immigrant identity transformation process.
The Role of Surface Hydroxylation, Lattice Vacancies and Bond Covalency in the Electrochemical Oxidation of Water (OER) on Ni-Depleted Iridium Oxide Catalysts
Authors: Nong Hong Nhan , Tran Hoang Phi , Spöri Camillo , Klingenhof Malte , Frevel Lorenz , Jones Travis E. , Cottre Thorsten , Kaiser Bernhard , Jaegermann Wolfram , Schlögl Robert , Teschner Detre , Strasser Peter
Published: December 2019

The usage of iridium as an oxygen-evolution-reaction (OER) electrocatalyst requires very high atom efficiencies paired with high activity and stability. Our efforts during the past 6 years in the Priority Program 1613 funded by the Deutsche Forschungsgemeinschaft (DFG) were focused to mitigate the molecular origin of kinetic overpotentials of Ir-based OER catalysts and to design new materials to achieve that Ir-based catalysts are more atom and energy efficient, as well as stable. Approaches involved are: (1) use of bimetallic mixed metal oxide materials where Ir is combined with cheaper transition metals as starting materials, (2) use of dealloying concepts of nanometer sized core-shell particle with a thin noble metal oxide shell combined with a hollow or cheap transition metal-rich alloy core, and (3) use of corrosion-resistant high-surface-area oxide support materials. In this mini review, we have highlighted selected advances in our understanding of Ir–Ni bimetallic oxide electrocatalysts for the OER in acidic environments.
Stomach gastrin is regulated by sodium via PPAR-α and dopamine D1 receptor
Authors: Xu Peng , Gildea John J , Zhang Chi , Konkalmatt Prasad , Cuevas Santiago , Bigler Wang Dora , Tran Hanh T , Jose Pedro A , Felder Robin A
Published: December 2019

Gastrin, secreted by stomach G cells in response to ingested sodium, stimulates the renal cholecystokinin B receptor (CCKBR) to increase renal sodium excretion. It is not known how dietary sodium, independent of food, can increase gastrin secretion in human G cells. However, fenofibrate (FFB), a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, increases gastrin secretion in rodents and several human gastrin-secreting cells, via a gastrin transcriptional promoter. We tested the following hypotheses: (1.) the sodium sensor in G cells plays a critical role in the sodium-mediated increase in gastrin expression/secretion, and (2.) dopamine, via the D1R and PPAR-α, is involved. Intact human stomach antrum and G cells were compared with human gastrin-secreting gastric and ovarian adenocarcinoma cells. When extra- or intracellular sodium was increased in human antrum, human G cells, and adenocarcinoma cells, gastrin mRNA and protein expression/secretion were increased. In human G cells, the PPAR-α agonist FFB increased gastrin protein expression that was blocked by GW6471, a PPAR-α antagonist, and LE300, a D1-like receptor antagonist. LE300 prevented the ability of FFB to increase gastrin protein expression in human G cells via the D1R, because the D5R, the other D1-like receptor, is not expressed in human G cells. Human G cells also express tyrosine hydroxylase and DOPA decarboxylase, enzymes needed to synthesize dopamine. G cells in the stomach may be the sodium sensor that stimulates gastrin secretion, which enables the kidney to eliminate acutely an oral sodium load. Dopamine, via the D1R, by interacting with PPAR-α, is involved in this process.
Producción científica peruana sobre cannabis en tres bases de datos
Authors: Chambergo-Michilot Diego , Velit-Rios Bruno
Published: December 2019

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Persistencia de la reemergencia de la rabia canina en el sur del Perú
Authors: Recuenco Cabrera Sergio
Published: December 2019

En el siglo pasado la rabia canina fue endémica en nuestro país. En la década de los 1990's, el Perú implementó el plan de acción para la eliminación de la rabia urbana por recomendación de la Organización Panamericana de la Salud, logrando un control exitoso de la rabia. Pese a los esfuerzos desplegados, Puno mantuvo focos endémicos persistentes, y en el 2014, Arequipa reportó el primer evento de reintroducción de rabia urbana en Latinoamérica. El brote de rabia se intensificó en los últimos años en Arequipa, Puno y Cusco, con 19 casos de rabia canina el 2015, a 59 casos el 2016, continuando el 2017 con 47 casos, el 2018 con 46, y hasta julio del 2019, 17 casos. Así, hubo reintroducción de la rabia canina, estableciendo una situación de alta endemicidad no controlada. En el presente reporte, abordamos el contexto y persistencia de la reemergencia de la rabia canina en el sur del Perú.
Síntesis histórica de estudios biosociales de la coca y la alimentación en Perú, 1948-1994
Authors: Ayala Pío Salomón , Quintana-Salinas Margot
Published: December 2019

El objetivo del presente artículo es ofrecer una perspectiva histórica de investigaciones sobre cocaísmo y alimentación en el hombre andino durante la segunda mitad del siglo XX. El hábito del cocaísmo fue considerado un importante problema de salud pública del Perú en los 40s, cuando el debate académico planteaba asociación entre deficiente alimentación y cocaísmo, atribuidos a la cocaína. Años después, estudios epidemiológicos apoyaron este paradigma. Desde los 70s, publicaciones antropológicas cuestionaron esta asociación y defendieron el uso social de la coca. En los años 80 se demostraron efectos farmacológicos de la coca y cocaína en la reducción del consumo de alimentos en animales de experimentación, que apoyaron la antigua hipótesis de Gutiérrez-Noriega.
Mathematical Modelling on RLCG Transmission Lines
Authors: Jiang Y.-L.
Published: December 2019

A new model on RLCG transmissions lines is presented in the paper. The model suits to be taken to directly simulating a circuit system in timedomain. Mathematically, a circuit system with distributed elements may be described by a special kind of nonlinear integral-differential-algebraic equations with multiple constant delays.
Global Observer for Homogegeous Vector Fields
Authors: Hammami M. A.
Published: December 2019

This paper presents an algebraic approach to the problem of nonlinear observer design. We show, that an observer which converges globally and asymptotically can be designed for a class of homogeneous systems of odd degree.
Value Distribution of General Dirichlet series. VI
Authors: Laurinčikas A.
Published: December 2019

In the paper a limit theorem in the sense of weak convergence of probability measures on the complex plane for a new class of general Dirichlet series is obtained.
Budget support for digitization within the E-government in Ukraine
Authors: Dulska Iryna
Published: December 2019

The paper deals with the issue of the budget financing of digitalization in Ukraine through e-governance.
It was shown that it is very difficult to estimate the real volume of public expenditures on digitalization (informatization) through e-government program at all budget levels and directions, since its components (national, sectoral, regional) are being implemented by many executive bodies and local governments. According to international organizations, the public access to information on budget spending in Ukraine is limited, and transparency level is insufficient, while the level of e-governance is high. However, the interfaces of e-government and e-budgets of the central and local government bodies are not unified, and are mostly inconvenient to users. The official websites provide outdated and limited information. The lack of transparency of the budget resources using reduces the trust of the general public in governmental institutions.
The organizational and institutional mechanism of budget financing of e-governance is studied based on the results of audits conducted by the authorized state bodies.
It is revealed that the main contractor of the subprograms implementation of the National Informatization Program – the State Agency for E-Governance of Ukraine – has not ensured a proper level of coordination, control, and systemic and consistent action, therefore important goals of the program have not been achieved. While the goals of digitalization of public services are declared as priority in Ukraine, the level of budget financing does not correspond to them. In case of the implementation of regional programs of informatization, insufficient control of the main spending units leads to poor performance or failures in their execution. Still unsolved remains the issue of determining the sources of financial support for the basic sectors of the social sphere, in particular, regarding measures for their digitization, within the framework of regional decentralization.
To deal with the above mentioned problems and challenges, it is recommended to establish a single coordinating body in the field of digitalization, including e-government, which should have ministry status and be built up on experience of countries, where similar bodies exist.
The publication is prepared during the research work "Formation" of smart specialization in the economy of Ukraine" (state registration number 0117U007701).
Substantiation of Parameters and Operating Modes for the Bunch Planting Device of the Pneumatic Seeder
Authors: Kravchenko Ivan A. , Krasnov Ivan N. , Potseluev Aleksandr A. , Sidorov Vladimir D.
Published: December 2019

The purpose of this work is to develop a dosing system that provides high-quality bunch planting of watermelon seeds with a given seeding rate and their uniform distribution over the plant nutrition area. It is important to know how many seeds it is needed in the bunch in order to provide the required number of plants in a certain plant nutrition area. The method to achieve this goal is to determine the optimal operating modes for the seeding device, in which the dosing system would supply the seed to the bunch without gaps, searching for dependencies that can determine the required number of the sown seeds in the bunch, taking into account their germination and the number of plants specified by agrotechnical conditions in every bunch. Based on the obtained dependencies, determining the probability of bunches with various numbers of plants, while sowing four seeds in the seedbed with maximum field germination, the design of experimental seed discs is proposed, allowing bunch planting and germination due to easy destruction of the soil crust. At the same time, optimal use of the nutritional area for plants, and, consequently, an increase in the yield of the sown crops is ensured. Experimental seed discs with a group arrangement of suction holes (four cells each) will provide bunch planting of watermelon seeds in accordance with agrotechnical requirements.
Virulence factors of Candida species from the oral mucosa and prostheses of elderly people from a riverside community in the Amazon state, Brazil
Authors: SILVA Daniela Marinho da , SOUZA Thayana Cruz de , ALENCAR Carol Falcão de Carvalho , SOUZA Ingrid da Silva de , BANDEIRA Maria Fulgência Costa Lima , FERNANDES Ormezinda Celeste Cristo
Published: December 2019

Abstract Introduction Candida albicans is the yeast most commonly affecting the oral cavity, sometimes causing infection. However, several factors may be associated with the onset of candidiasis, which may be related not only to the hygiene and health of individuals, but also to the pathogenicity of these microorganisms. Objective To evaluate the virulence factors of Candida yeasts isolated from the oral mucosa of elderly people living in the “Comunidade Lago do Limão”, municipality of Iranduba, Amazonas state, Brazil. Material and method Testes were performed to assess the production of urease, proteinase, phospholipase and hemolysin. Statistical analysis used the Fisher's exact test and the Chi-squared test. Result Prevalence of non-albicans species was observed. As for virulence factors, all isolates were negative ureases, and there was prevalence of very strong proteinase production, whereas most isolates did not produce this enzyme in the phospholipase test. All yeasts analyzed presented hemolysin production, with grade IV hemolysis as the most prevalent. There was no statistically significant difference between the virulence of isolates from the oral cavity and the prostheses of the elderly analyzed. Conclusion Several virulence factors may present with high intensity in the presence of oral microbiota changes. In addition, non-albicans species present number of virulence factors similar to that of C. albicans, with high pathogenicity. This study allows a better analysis of candidiasis prevention strategies aiming to promote improvement in the health and quality of life for the elderly.
Prevalence and factors associated with shoulder pain in the general population: a cross-sectional study
Authors: Bento Thiago Paulo Frascareli , Genebra Caio Vitor dos Santos , Cornélio Guilherme Porfírio , Biancon Rangel Dal Bello , Simeão Sandra Fiorelli Almeida Penteado , Vitta Alberto De
Published: December 2019

ABSTRACT Musculoskeletal pain in the shoulder is considered one of the most prevalent causes of pain and disability in adults. To verify the prevalence of shoulder pain and correlated factors in adults aged 20 years or older in cross-sectional study with 600 individuals interviewed through questionnaires: (1) participants characterization; (2) level of physical activity; (3) reported morbidities; and (4) musculoskeletal symptoms. Descriptive, bivariate, and Poisson regression analyses were performed. The prevalence of pain in the shoulder was 24% (CI 20.3%-27.5%). Being 60 years or older (PR=2.14; 1.33-2.45), female (PR=1.92; 1.29-285), using the computer more than three times a week (PR=1.55; 1.01-2.32), working in a sitting position (PR=1.64; 1.03-2.59), standing up leaning the body forward (PR=1.54; 1.00-2.37), and reporting two or more morbidities (PR=3.31; 1.97-5.57) were all indicators of shoulder pain. This study discloses a high prevalence of shoulder pain and a strong relation with women, age, those who use the computer more than three times a week, those who execute occupational activities sitting and standing up leaning the body forward, and those who report two or more diseases.