bluuebunny/crossref_metadata_2025 huggingface dataset:
Dissent: Perspectives from the Book of Mormon
Authors: Wardle Lynn D.
Published: November 2022

Most scriptural references to dissent are in the Book of Mormon. The Book of Mormon teaches that dissension is a cause of evil, suffering, and destruction; some dissenters undergo a hardening, while others may be reclaimed; preaching the gospel is the best way to reclaim dissenters; after patient endurance, compulsion may be necessary to stop militant dissenters from causing severe harm to the innocent, but compulsion should be avoided when possible; both spiritual and civic responses may be used to quell dissent; responding to dissent is not the task of leaders only; dissent is inevitable in our society and the church; and the Lord blesses the faithful who endure the trials and temptations of dissent.
Enallage in the Book of Mormon
Authors: Barney Kevin L.
Published: November 2022

Thomas W. Brookbank long ago suggested that enallage, meaning the substitution of the singular for the plural or vice versa for rhetorical effect, is present in the Book of Mormon. Enallage does appear to exist as a prominent, meaningful rhetorical figure in the Bible, but its presence in the Book of Mormon is more difficult to demonstrate given the pronominal variation found in the Book of Mormon, a factor that Brookbank did not account for in his study. Nevertheless, a careful reading of contextual and verbal clues reveals that enallage does indeed appear to exist in some passages in the Book of Mormon. An awareness of this usage is important for a full understanding of such passages.
Historical Parallels to the Destruction at the Time of the Crucifixion
Authors: Tvedtnes John A.
Published: November 2022

To the nonbeliever, the wide variety of destructive forces unleashed in the New World at the time of Christ’s crucifixion seems preposterous or, at the very least, unscientific. The account in 3 Nephi 8-9 mentions the simultaneous occurrence of earthquake, fire, strong winds, extensive flooding, the complete burial of cities, and thick darkness. An examination of known great natural disasters in historical times reveals that the Book of Mormon in no way exaggerates. All of the destructive forces mentioned in 3 Nephi 8-9 can be readily explained in terms of the tectonic forces that result from the encounter of the plates on which the continents and the oceans lie. The complex variety of destructive forces that we normally consider to be separate phenomena of nature is, in reality, strong evidence for the historicity of the Book of Mormon account.
A cell-surface autoantibody targets zinc transporter-8 (ZnT8) for in vivo B-cell imaging and islet-specific therapies
Authors: Guo Zheng , Kasinathan Devi , Merriman Chengfeng , Nakayama Maki , Li Hua , Li Huilin , Xu Cheng , Wong G. William , Yu Liping , Golson Maria L. , Fu Dax
Published: November 2022

Type 1 diabetes (T1D) is a disease in which autoimmune attack is directed to the insulin-producing b-cell in the pancreatic islet. Autoantigens on the b-cell surface membrane are specific markers for molecular recognition and targets for engagement by autoreactive B lymphocytes, which produce islet cell surface autoantibody (ICSA) upon activation. Here, we report the cloning of an ICSA (mAb43) that recognizes a major T1D autoantigen, ZnT8, with a subnanomolar binding affinity and conformation specificity. We demonstrate that cell-surface binding of mAb43 protects the extracellular epitope of ZnT8 against immunolabeling by serum ICSA from a patient with T1D. Further, mAb43 exhibits in vitro and ex vivo specificity for islet cells, mirroring the exquisite specificity of islet autoimmunity in T1D. Systemic administration of mAb43 yields a pancreas-specific biodistribution in mice and islet homing of a mAb43-linked imaging payload through the pancreatic vasculature, thereby validating the in vivo specificity of mAb43. Identifying ZnT8 as a major antigenic target of ICSA allows for research into the molecular recognition and engagement of autoreactive B cells in the chronic phase of T1D progression. The in vivo islet specificity of mAb43 could be further exploited to develop in vivo imaging and islet-specific immunotherapies.
Corrigendum: Risk of reoperation due to surgical site infection in 74,771 hip fracture patients: a Danish nationwide cohort study
Authors: Kristensen Nicolai K , Lange Jeppe , Frøslev Trine , Pedersen Alma B
Published: November 2022

Corrigendum of Acta Orthop 2022; 93: 760–766. doi: https://doi.org/10.2340/17453674.2022.4580
Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study
Authors: Kuru Hanna , Jokelainen Jari , Tasanen Kaisa , Huilaja Laura
Published: November 2022

Evidence of the association between a personal history of basal cell carcinoma and the risk of non-cutaneous malignancies is conflicting. The aim of this study was to retrospectively clarify the risk of non-cutaneous cancers in individuals with basal cell carcinoma using nationwide Finnish registry data for 96,304 patients and 394,503 randomly selected population controls. In this study, individuals with basal cell carcinoma have an increased risk of other cancers (odds ratio (OR) 1.38; 95% confidence interval (95% CI) 1.36–1.40). The risk was most prominent for lip cancer (OR 5.29; 95% CI 4.50–6.21), mycosis fungoides (OR 3.13; 95% CI 2.31–4.23) and soft tissue cancers (OR 2.77; 95% CI 2.43–3.16). In age-adjusted model, men had higher risk of cancers overall compared with women (p < 0.05). In conclusion, the study found increased overall cancer risk among patients with basal cell carcinoma compared with randomly selected population controls.
Krav til utredning av miljøkonsekvenser i vann
Authors: Nerbø Karen Hjelmervik
Published: November 2022

Environmental impact assessments (EIA) are an important tool in Norwegian environmental law. The article reviews different rules for impact assessment in Norwegian law and discusses these rules’ interrelation. It discusses when the obligation to do an EIA arises, and the information an EIA should contain. It also raises the question of whether or not these rules provide sufficient information for decision-makers about long-term and cumulative environmental effects.
Overvannshåndtering i byggesak – tiltakshavers ansvar og plikter
Authors: Hagen Karoline
Published: November 2022

Increasing urbanization, densification of areas across the country, and more frequent episodes of extreme rainfall pose major challenges to handling stormwater. Property developers must ensure that stormwater does not cause damage as a result of their construction work. When constructing new buildings, the Norwegian Planning and Building Act is an important tool for municipalities to use to set conditions for controlling stormwater.

As the legal regulation relating to stormwater management imposes duties which developers must fulfill, they may face practical challenges. Also, changes to some of the rules in the Planning and Building Act have been suggested. Some of the new rules will lead to new solutions for handling stormwater – and new discussions as well.
Grunneiers rett til erstatning ved kommunal klausulering til drikkevann
Authors: Jakobsen Guttorm
Published: November 2022

For the purpose of protecting sources of drinking water by imposing restrictions on the use of area, municipalities can rely on two acts in Norwegian legislation: the Planning and Building Act and the Expropriation Act.

The purpose of this article is to shed light on the degree to which a landowner is entitled to compensation for municipal restriction of use of area for the purpose of protecting drinking water, and possible differences in compensation based on these different legal bases.

Such differences can exist: When rights are expropriated, the owner will always be entitled to full compensation for expected economic loss, but conversely, if the owner receives restrictions on his rights to dispose his property but still retains ownership of the ground, the main rule favours the other side; the owner is not entitled to compensation for losses caused by these restrictions.
Gjennomføring av vannforskriften og vannforvaltningsplaner i kommunal arealplanlegging etter plan- og bygningsloven
Authors: Larsen Ingrid Wang , Solli Gunnhild Storbekkrønning
Published: November 2022

As a result of the EU Water Framework Directive and Norwegian water regulations, river basin management plans (vannforvaltningsplaner) shall be incorporated into municipal, county and state sectors. The main purpose of the river basin management plans is to adapt environmental objectives for chemical, ecological and quantitative conditions for water bodies. At the same time, the planning process shall ensure comprehensive and integrated water management. The aim of this article is to shed light on the significance of river basin management plans and water regulations for municipal spatial planning set forth in the Planning and Building Act: What is the relationship between the river basin management plans and other spatial management plans adopted under the Planning and Building Act? Which instruments in the “local planning toolbox” of the Planning and Building Act can enhance efficient implementation? In addition, we reflect on how the European modelled river basin management plans fit into the landscape of the Planning and Building Act for spatial planning processes.
KHAMR IN THE QUR'AN (THEMATIC STUDY OF TAFSIR IBN JARIR AL-TABARI)
Authors: Adiansyah Ridho , Yahya Nurul Faezah binti
Published: November 2022

Food and drink are basic needs for humans to meet the body's intake needs, both for growth and for energy in daily activities. Allah SWT. ordered people to look for food and drink that is lawful and good (Qs. al-Baqarah / 2: 168, 172) This has been regulated since the revelation of the Islamic treatise. In Islamic law, it is strictly prohibited and even forbidden to consume drinks containing alcohol, such as khamr and the like. However, there are still many cultural phenomena in certain Muslim societies where people consume alcoholic beverages, or khamr, and do not pay attention to the effects of consuming alcohol. This research focuses on issues related to the need for a new interpretation that is more contextual by using the object of the al-?abari interpretation book as the main reference. Because the book of al-?abari, contains a wealth of sources and previous history, especially in terms of the meaning of words and the use of Arabic. In this essay, the author uses a type of library research (library research) using a descriptive-analytical method. The results of the research show that Allah SWT. really loves and cares for each of his servants so they don't fall into immoral behavior, such as khamr and the like. Because khamr is very dangerous for the health of the human body, and can cause a loss of awareness of reason and intellectual abilities.
Identifikasi Zona Potensi Longsor Menggunakan Metode Fotogrametri Foto Udara Area Pidada Kota Bandar Lampung
Authors: Wibowo Rahmat Catur , Rizkiano Aldika , Sarkowi Muh
Published: November 2022

Tanah longsor mencakup berbagai fenomena yang melibatkan gerakan tanah di lereng bawah, seperti runtuhan batuan, longsoran lereng dalam, dan aliran puing dangkal yang disebabkan oleh gravitasi yang bekerja pada suatu lereng.  Untuk menghindari tingginya kerugian akibat bahaya bencana tersebut maka diperlukan upaya meminimalisir salah satunya dengan melakukan pemetaan area potensi bencana tanah longsor. Penelitian ini bertujuan untuk mendapatkan zona daerah potensi bencana longsor berdasarkan data kelas lereng, curah hujan dan geologi regional daerah penelitian. Hasil pengolahan dari 74 gambar data drone dan ekstraksi DSM didapatkan DTM menggunakan terain filter flat pada pengolahan Agisoft Metashape dan PCI Geomatica 2015. Berdasarkan hasil DTM didapatkan kelas lereng yaitu datar (0º – 2º) 19,36%, landai (2º – 4º) 30,65%, miring (4º – 8º) 19,72%, agak curam (8º – 16º) 16,4%, curam (16º – 35º) 8,03%, sangat curam (35º – 55º) 4,58%, dan lereng terjal (>55º) 1,27%. Berdasarkan analisis data kelas lereng, data curah hujan tahunan dan peta geologi regional terdapat daerah potensi tanah longsor dengan area yang ditandai dengan simbol berwarna jingga hingga merah dengan total luasan 0,866 ha dengan kemiringan curam (0,501 ha), sangat curam (0,286 ha) dan lereng terjal (0,079 ha)
Pemetaan Zona Agroklimat Oldeman di Provinsi Jawa Tengah Menggunakan Data Climate Hazards Group Infrared Precipitation with Station (CHIRPS)
Authors: Madani Ilyas , Wahid Khalil Abdul
Published: November 2022

Pembuatan informasi iklim Oldeman yang berguna untuk sektor pertanian membutuhkan data curah hujan dalam jangka waktu yang cukup lama. Dalam penelitian ini, Climate Hazards Group Infrared Precipitation with Station (CHIRPS) digunakan sebagai basis data curah hujan untuk pemetaan zona agroklimat Oldeman terbaru di Provinsi Jawa Tengah. Data CHIRPS selama 30 tahun mulai dari 1992─2021 diolah menggunakan metode interpolasi Inverse Distance Weighted dan overlay melalui sistem informasi geografis sehingga dapat dihasilkan peta agroklimat Oldeman Provinsi Jawa Tengah. Peta yang dihasilkan menunjukkan bahwa terdapat tujuh zona agroklimat Oldeman di Provinsi Jawa Tengah, yaitu B1 (7,1%), B2 (30,6%), B3 (0,9%), C2 (15,9%), C3 (33,1%), D2 (0,2%), dan D3 (12,3%). Zona B1, B2, dan B3 yang berada di bagian barat dan selatan cocok untuk dua kali tanam padi dan sekali tanam palawija di saat musim kemarau. Zona C2 dan C3 yang berada di bagian timur dan utara cocok untuk sekali tanam padi dan dua kali tanam palawija. Zona D2 dan D3 yang berada di timur laut dan sebagian utara hanya cocok untuk sekali tanam padi atau palawija. Peta agroklimat yang dihasilkan dapat menjadi acuan pola tanam yang sesuai untuk wilayah Provinsi Jawa Tengah
Performance Evaluation of LSTM and RNN Models in the Detection of Email Spam Messages
Authors: John-Africa Elijah , Emmah Victor T.
Published: November 2022

Email spam is an unwanted bulk message that is sent to a recipient’s email address without explicit consent from the recipient. This is usually considered a means of advertising and maximizing profit, especially with the increase in the usage of the internet for social networking, but can also be very frustrating and annoying to the recipients of these messages. Recent research has shown that about 14.7 billion spam messages are sent out every single day of which more than 45% of these messages are promotional sales content that the recipient did not specifically opt-in. This has gotten the attention of many researchers in the area of natural language processing. In this paper, we used the Long Short-Time Memory (LSTM) for classification tasks between spam and Ham messages. The performance of LSTM is compared with that of a Recurrent Neural Network( RNN) which can also be used for a classification task of this nature but suffers from short-time memory and tends to leave out important information from earlier time steps to later ones in terms of prediction. The evaluation of the result shows that LSTM achieved 97% accuracy with both Adams and RMSprop optimizers compared to RNN with an accuracy of 94% with RMSprop and 87% accuracy with Adams optimizer.
Prediction of Heart Disease Using Machine Learning Algorithms
Authors: Nayeem Md. Julker Nayeem , Rana Sohel , Islam Md. Rabiul
Published: November 2022

Heart disease has become one of the alarming issues of death. It is accountable for fatty plaques in the arteries. If this fatal condition can be identified early, we can preserve many people’s arteries. Different types of supervised machine learning algorithms are applied in our research paper in order to predict heart disease existence in patient body. Besides this, we have focused on an efficient way to improve the performance of our applied classifiers. Imputing mean value technique is applied to handle null values present in our dataset. The features which are unnecessary are removed by using the info-gain feature selection technique. In order to calculate prediction accuracy, K-Nearest Neighbors (KNN), Naive Bayes and Random Forest are applied to the heart disease dataset. Accuracy, precision, recall, F1-score, and ROC are calculated which help us to compare the performance of the classification models. Handling null values on a particular column by imputing mean values of that column and our applied info-gain feature selection technique has aided us in improving the accuracy of our prediction models. Random Forest among all has given the best classification accuracy which is 95.63% with precision, recall, F1-score and ROC are 0.93, 0.92, 0.92 and 0.9, respectively.
A Synchronous Blind Test and Methodological Comparison Between Colloidal Gold Rapid Test vs RT-PCR For Sars-Cov-2 Detection
Authors: Mourtzikou Antonia , Tsiftsis Dimitrios , Agrogianni Maria , Kasimatis Nikolaos , Dritsa Anthoula , Stamouli Marilena , Koumpouros Panagiotis , Seitopoulou Christina , Toka Elpida
Published: November 2022

Background: The current pandemic due to novel SARS-CoV-2 virus dramatically affected health care systems and public health worldwide. The present study aimed to evaluate two analytical methods, colloidal gold antigen rapid test vs reference PCR for the detection of SARS-CoV-2. The patients enrolled in the trial were admitted at the emergency department of a tertiary care hospital, with symptoms of suspected COVID-19 disease.
Methods: A total of 300 patients participated in the study. Patients’ age, gender and result from the Colloidal antigen rapid test were recorded. PCR detection for SARS-CoV-2 was then applied, according to the manufacturer’s instructions. Statistical analysis of all collected data was performed for sensitivity, specificity, ROC curves, PV+, PV- and Cohen’s kappa coefficient. McNemar’s chi-squared test and p-values were also tested.
Results: A p-value=0.045 from McNemar’s chi-squared test for CI 95% was observed, so H0 marginally is not rejected. The sensitivity of colloidal gold antigen rapid test was 79%, the specificity 96%, PV+89%, PV-91% and the kappa coefficient=0.79 (>0.5) that correlates to substantial agreement according to Cohen’s Kappa interpretation.
Conclusions: Through the methodological comparisons and according to WHO guidelines for the sensitivity, specificity and kappa coefficient that correlates to substantial agreement the Colloidal Gold Antigen Rapid Test for SARS-CoV-2 meet the needs of clinical test in the emergency unit playing an important role in the context of mass patient screening and screening in remote areas.
ANALYSIS OF CONCEPTS UNDERSTANDING AND STUDENTS' ATTITUDES TOWARDS LEARNING PHYSICS IN PARABOLIC MOTION AT SMAN KOTA PARIAMAN
Authors: Fauziah Siti , Mufit Fatni , Ramli - , Afrizon Renol , Hidayat Zaitul
Published: November 2022

Understanding the concepts and attitudes of students is one of the essential things in learning. Based on previous researchers’ research, many students have low conceptual understanding or high misconceptions. In addition, students' attitudes towards learning physics are also considered less good. This study aims to determine: 1) students' conceptual understanding of the parabolic motion material, 2) students' attitudes towards learning physics, and 3) the relationship between conceptual understanding and student attitudes towards learning physics.This study uses a quantitative descriptive method. The sample consisted of 81 students from 3 high schools in Kota Pariaman, representing low, mediu, and high-level schools. The research instrument was in the form of a four-tier multiple-choice concept test about parabolic motion and a questionnaire about students' attitudes towards learning physics. The data analysis technique used is a combination of answers for the concept test and Likert Scale scoring to analyze the questionnaire. The relationship between conceptuaal understanding and attitude was analyzed using Pearson's product-moment correlation.The results showed that students experienced more misconceptions with a fairly high percentage (42,6-72,3). The results of the student attitude questionnaire showed that the indicators of student social implications had the highest percentage (72.3-77.4), and pleasure in learning physics had the lowest percentage (64.8-66.1). The relationship of understanding of concept with te attitude of the student using product moment correlation with a 5% significance three level for high school category show a moderate show a medium correlation and weak correlation with a positive relation of meaning that if the student’s attitude rose then the understanding of the concept of student will also rise or increase as well as otherwise. For students' attitudes, who found that the students' social implication indicators had a higher percentage and the pleasure in learning physics had a lower percentage. Regarding the relationship between attitudes and understanding of students' concepts, there is a moderate correlation, which means that students' attitudes also influenced students' understanding
Optimization of Nanosilver Synthesis Process with Bioreductor of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis)
Authors: Dwiastuti Rini , Irnandari Elsa , Gani Michael Raharja , Yuliani Sri Hartati , Nastiti Christofori Maria Ratna
Published: November 2022

Nanosilver is a type of metallic silver nanoparticles and has a particle size of 1-100 nm. The method used in the synthesis of nanosilver is a chemical reduction method with silver metal precursor AgNO3 and a bioreductant of binahong leaf extract containing flavonoid compounds. This study aims to obtain the duration, temperature and optimum point in the synthesis of nanosilver with the bioreductant of binahong leaf extract using the sonication method. This type of research is purely experimental with a 2x2 factorial design. The nanosilver characterization was conducted by determining the optimum wavelength and the transmittance value of the nanosilver formed. The effect of temperature and duration of sonication on the wavelength and % transmittance of the synthesized nanosilver in this study were analyzed by ANOVA statistical test using the Minitab 19 application with a 95% confidence level. In this study, the temperature and duration of sonication as well as their interactions have an effect on the transmittance response. The statistical results of the model have a significant effect on the % transmittance response only with p-value <0.05. The optimum point was found in the synthesis of nanosilver with the bioreductant of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) using a 2x2 factorial design, namely at a sonication temperature of 80°C for 10 minutes, a sonication temperature of 70oC for 15 minutes and a sonication temperature of 80oC for 15 minutes.
Comparison of implicit time-discretization schemes for hybridized discontinuous Galerkin methods
Authors: Levý Tomáš , May Georg
Published: November 2022

The present study is focused on the application of two families of implicit time-integration schemes for general time-dependent balance laws of convection-diffusion-reaction type discretized by a hybridized discontinuous Galerkin method in space, namely backward differentiation formulas (BDF) and diagonally implicit Runge-Kutta (DIRK) methods. Special attention is devoted to embedded DIRK methods, which allow the incorporation of time step size adaptation algorithms in order to keep the computational effort as low as possible. The properties of the numerical solution, such as its order of convergence, are investigated by means of suitably chosen test cases for a linear convection-diffusion-reaction equation and the nonlinear system of Navier-Stokes equations. For problems considered in this work, the DIRK methods prove to be superior to high-order BDF methods in terms of both stability and accuracy.
Improving investment mechanism for project financing of blocks of flats construction
Authors: Nabiev Ramazan Abdulmuminovich , Kurdyuk Andrey Yur'evich , Yanborisov Ravil Rashidovich
Published: November 2022

The article presents analysis of the investment support of the primary residential real estate market, which identifies the features of project financing for the construction of apartment buildings in modern conditions. Analysis of the reproduction of the housing stock in the Astrakhan region was carried out on the basis of statistical data. There was pointed out a decline in the commissioning of housing, a negligible increase in the volume of housing stock in the region along with increasing figures of housing provision. The methods of calculating the housing affordability coefficient were analyzed, their shortcomings were noted and proposals were prepared for adjusting the factors considered in the calculations. The practice of the primary residential real estate market functioning has been investigated and the influence of factors and conditions on the housing price has been defined. Based on the analysis of the investment and organizational mechanism of project financing of housing construction using escrow accounts, the problems and bottlenecks were identified, methods for solving these problems were developed: a scheme for choosing design solutions and a mechanism for step-by-step disclosure of escrow accounts. Recommendations are proposed to increase the investment attractiveness of the projects including the developer’s choice of the optimal financing strategy and sales strategy, the formation of the object image before the start of sales, a rational combination of design solutions, a reduction in the number of storeys in block of flats to increase the comfort of the urban environment and a favorable impact on purchasing power.
Effectiveness of natural lip balm cinnamon (Cinnamomum burmannii) in accelerating the incision wound healing process in  rattus norvegicus
Authors: Damayanti Meta Maulida , Sari Ajeng Kartika , Furqaani Annisa Rahmah
Published: November 2022

ABSTRACT Introduction: Cinnamomum burmannii is commonly used in the treatment and is thought to be an anti-inflammation medicinal herb that may hasten recovery. Lip wound healing is a critical need for aesthetic performance. The purpose of this study is to evaluate the efficacy of natural lip balm C. Burmannii has been shown to speed up the healing of incision wounds in rats (Rattus norvegicus). Methods: This research was carried out in the laboratory biomedical Faculty of Medicine, Universitas Islam Bandung. In twenty-seven male rats weighing 200-300 g, a lip mucous incision of 10 mm length and 4 mm depth was surgically created. Simple random sampling was used to divide the animals into three treatment groups based on wound treatment after lip incision (The control group applied distillation water, the first group applied a lip balm placebo/base, and the second group applied natural lip balm C. burmannii) and then divided into three observation times (days 3rd, 7th, and14th). A lip biopsy was performed during each observation time to determine the success of the therapy. The macroscopic examination was carried out by counting the number of lip wounds that were closed around, while the microscopic examination was carried out by counting epithelialization with a Leica microscope and image raster software. Result: The length of the lip wound has greatly decreased in the C. Burmannii group with a p-value of 0,048 (p<0.05, and epithelialization was comparable across the board. Conclusion: The use of Cinnamomum burmannii natural lip balm is effective in accelerating lip wound healing by bringing the lip wound closer together. Effectiveness of Natural lip balm Cinnamon (Cinnamomum burmannii) in accelerating the incision wound healing process in Rattus norvegicus.Keywords: natural lip balm cinnamomum burmannii; wound closer; epithelialization
Formulation of Mouthwash for Gingivitis from Combination Infusion of Salam leaves (Eugenia Polyantha Wight) and Betel leaf (Piper betle. L)
Authors: Putri Megananda Hiranya , Julaeha Euis , Herijulianti Eliza , Nurjanah Neneng
Published: November 2022

ABSTRACTIntroduction: Gingivitis is inflammation of the gingiva associated with bacterial activity in dental plaque. The combination of bay leaves and betel leaves infusion has been used as a toothbrush disinfectant. The purpose of this study was to obtain a stable and effective mouthwash formulation from the combination of both infusions to prevent and relieve gingivitis. Methods: Five mouthwash formulas were made by mixing the active ingredients which is a combination of bay leaves and betel leaves infusion, with additives. The combination namely F-I (100% : 0%); F-II (75% : 25%); F-III (50% : 50%); F-IV (25% : 75%) and F-V (0%: 100%). Antibacterial activity tests against Streptococcus mutans, Streptococcus sanguis, and Porphyromonas gingivalis and physical stability tests were carried out. Stability test was carried out by storing the formula at room temperature (280C), hot temperature (400C) and cold temperature (40C) for 3 storage cycles (6 weeks) and observing changes in the physical indicators of the solution, namely pH, specific gravity, viscosity and organoleptic conditions, namely homogeneity, clarity, color, aroma and taste at the end of every 2nd week. Results: F-I to F-V had no inhibitory activity against Streptococcus mutans and Streptococcus sanguis, but had inhibitory activity against Porphyromonas gingivalis in the range (7.19±0.48) to (8.29 ±0.82) mm (ANOVA with a significance value of 0.237 > 0.05).  The 5 formulas were more stable at cold storage, with organoleptic observations at the end of the 3rd cycle showing a slight precipitate (+), clear solution, light brown color, mint aroma and sweet taste. F-II formulas showed better physical indicators values because they were closer to the standard values. Conclusion:  The F-II formula is recommended as a mouthwash for gingivitis because significant for antibacterial effect and showed better physical indicators values as the standard values for herbal medicines.Keywords: antibacterial activity; bay leaves - betel leaves infusion; gingivitis; mouthwash formulation.
Współczesne Metody Identyfikacji Białkowych Antygenów Szczepionkowych
Authors: Jabłuszewski Rafał , Wyszyńska Agnieszka
Published: November 2022

Streszczenie

Postępy w genomice związane z ustawicznym sekwencjonowaniem kompletnych genomów drobnoustrojów, w tym mikroorganizmów patogennych, zrewolucjonizowały podejście do wyboru i projektowania antygenów szczepionkowych nowej generacji. Odwrócono klasyczny proces badawczy, ponieważ to zbiór danych genomowych stał się źródłem hipotez o immunogenności wytypowanych antygenów. W efekcie, możliwe jest wydajne przeanalizowanie tysięcy genów, niezależnie od poziomu ich ekspresji in vivo. Na tej podstawie typuje się pulę białkowych kandydatów, które można następnie poddać dalszym badaniom i dokładnie opisać ich epitopy powierzchniowe rozpoznawane przez elementy układu odpornościowego człowieka. Informacje o strukturze wybranego antygenu i jego interakcjach z układem immunologicznym mogą posłużyć do syntezy nowych cząsteczek, optymalizując czas i środki niezbędne do wprowadzenia do użytku nowego preparatu szczepionkowego.
Mikrobiom Przewodu Pokarmowego Człowieka – Wybrane Dane
Authors: Tokarz-Deptuła Beata , Dudziak Paulina , Gurgacz Natalia , Deptuła Wiesław
Published: November 2022

Streszczenie

W pracy przedstawiono nowe dane wskazujące na skład mikrobiomu przewodu pokarmowego człowieka, składający się z bakterii, archeonów, wirusów (w tym bakteriofagów), a także organizmów eukariotycznych i heterotroficznych jakimi są grzyby – których bytowanie w przewodzie pokarmowym określane jest mianem mykobiomu. Przewód pokarmowy człowieka podzielony na jamę ustną, gardło, przełyk, żołądek, jelito cienkie i grube, zasiedlany wyżej wymienionymi drobnoustrojami, tworzy swoisty jakościowo-ilościowy, bogaty i zróżnicowany swoisty ekosystem. Dzięki stosowaniu metod bioinformatycznych, molekularnych oraz dzięki sekwencjonowaniu metagenomowemu jest on nadal poznawany, a dzięki tym metodom możliwe jest jego lepsze poznanie. W niniejszej pracy scharakteryzowano grupy systematyczne bakterii, archeonów, wirusów i grzybów występujące w poszczególnych odcinkach przewodu pokarmowego i wskazano także na enterotypy jelita grubego. Analizując wymienione grupy mikroorganizmów w poszczególnych odcinkach przewodu pokarmowego człowieka, należy zauważyć, że odcinek jelita grubego i jamy ustnej jest „wyposażony” w najbardziej bogaty mikrobiom, natomiast gardło i przełyk posiada najmniejszą liczbę drobnoustrojów wchodzących w skład mikrobiomu. Wśród całości mikrobiomu przewodu pokarmowego człowieka najliczniejszą grupę stanowią bakterie usytuowane w jamie ustnej i jelicie cienkim, zaś najbardziej ograniczoną grupę bakterii rejestruje się w gardle i przełyku. Archeony natomiast zostały opisane najliczniej w jelicie grubym i jamie ustnej, a nie zostały stwierdzone w gardle i jelicie cienkim. Wymieniane w odcinkach przewodu pokarmowego wirusy, najliczniej występowały w jelicie grubym i jamie ustnej, natomiast nie stwierdzono ich w żołądku. Występujące w mikrobiomie grzyby, najobficiej stwierdzane były w jelicie grubym i żołądku, a w najmniejszej ilości w gardle i jelicie cienkim.
Demand for Additional Foreign Language Activities in Poland
Authors: Kłobuszewska Małgorzata
Published: November 2022

This paper addresses the issue of participation in additional activities in foreign languages among Polish students aged 7–15. Foreign language skills are important in recruitment to secondary school and university. In the labour market, there is also a considerable wage premium for foreign language skills. Participation in such activities is therefore a form of investment in human capital. In this work we distinguish two kinds of additional foreign language activities: paid and free, and we show their different characteristics, which is our contribution to the literature. We check whether the key factors on the demand and supply side of additional activities such as family socio-economic status (SES) and size of the place of residence affect the participation in paid and free activities in a similar way. We also examine gender differences in additional foreign language activities participation. For the purpose of our analysis, we use data from the second round of the Determinants of Educational Decisions study (UDE) and apply the multinomial logit regression model. Our results indicate that family SES and size of the place of residence are important factors for probability of participation in paid foreign language activities. For participation in free activities, family SES does not matter. Therefore, these classes can contribute to equalising educational opportunities. We also find that girls are more likely to participate in both paid and free activities in foreign languages.
Splitting of Corporate Taxes in Germany and Formulaic Distribution of a CCCTB – Critical Comparison
Authors: Müller-Thomczik Sandra , Reiter Lukas
Published: November 2022

The introduction of a formulaically apportioned common consolidated corporate tax base (CCCTB) could represent a milestone in international taxation. No agreement has yet been reached, however. In contrast, Germany already has a long-standing system that apportions corporate taxes by splitting trade tax and corporate income tax. This conceptual study, presented at the European Accounting Association (EAA) Congress in Bergen in 2022, will examine whether the German method of splitting could lead to some lessons for an appropriate design for an international profit distribution formula.

Methodologically, we use a two-step approach: First, we compare the designs, and then we juxtapose both on a factual level. Next, we ask what the objectives these mechanisms have; do they even coincide? If the goals are not comparable, one cannot indisputably serve as a model for the other. We determine that, even though there are partial deviations, a closer look reveals significant overlaps; however, the German implementation is far from consistent and prioritises practicability. This leads us to our main result: The German system makes a clear value decision towards practicability, although there is a different set of aims. For the implementation of formulaic EU profit sharing, the lesson to be learned is that practicability should play a central role in the design of the formula. This lesson is important and helpful to accompany and support the implementation process in the EU.
В.К. Арсеньев и его интересы в геологии
Authors: Хисамутдинов Амир Александрович
Published: November 2022

В статье, посвящённой 150-летию со дня рождения известного путешественника и исследователя Владимира Клавдиевича Арсеньева, раскрываются его геологические интересы. Сторонник комплексных экспедиций, он наряду с основными задачами всегда уделял внимание сбору разнообразных научных сведений, в том числе геологических. Сообщается об изучении Арсеньевым геологии и его связях с учёными-геологами Э.Э. Анертом, И.П. Толмачёвым, П.В. Виттенбургом, А. Либусом и др. Основными источниками для публикации послужили личный архив и библиотека В.К. Арсеньева, хранящиеся в Обществе изучения Амурского края (Владивосток). Ключевые слова: В.К. Арсеньев (1872–1930), российский Дальний Восток, история науки, дальневосточная геология, краеведение
Recurrent foot ulcers in patients with diabetes mellitus in out-patient care
Authors: Bregovskiy V. B. , Demina A. G. , Karpova I. A.
Published: November 2022

OBJECTIVE. Relapses of diabetic foot ulcers are an urgent problem of outpatient surgery, however, risk factors for relapse, as well as the definition of relapse itself remain a subject of discussion. The presented study investigates the frequency of relapses of ulcerative foot defects in diabetes mellitus, the risk factors for their development and treatment outcomes, based on the definition of relapse as the development of a repeated defect in the same place as the healed defect.METHODS AND MATERIALS. The data of 1714 patients with foot ulcers (2213 ulcerative defects) from 01.2012 to 01.2017 were studied. Patients were divided into two groups: with relapses (n=239, 13.9%) and without them (n=1475). Risk factors for relapse, characteristics of patients and ulcerative defects, and treatment outcomes were evaluated.RESULTS. Relative risk for relapse: type 1 diabetes mellitus (1.36); Charcot foot (1.65); history of amputation of the great toe (1.35); severe polyneuropathy (1.25); neuropathic foot (1.37). Relapses/single ulcer (%): superficial lesion 72.8/63.3 (р<0.01); primary healing: 61.1/52.7 (p=0.025); healing after surgery (amputations excluded): 4.2/4.5 (ns); amputations: 7.1/6.6 (ns) of which major 5.9/20.6 (p=0.01); non-healing (%): 11.7/5.5 (р=0.001); loss of follow-up (%): 15.9/30.7 (р=0.0001). Median duration of the treatment (days) of relapses/single ulcer: conservative 147/114; healing after surgery (amputations excluded) 241/170; after amputation 286/182. Revascularization in relapses – 7 (100%), with single ulcers – 66 (59.5% of patients with critical ischemia).CONCLUSION. 5-years relapse rate was 13.9 %. Patients with Charcot foot, postoperative deformities and with neuropathic form of diabetic foot syndrome are more prone for foot reulceration. Recurrent ulcers are characterized with longer duration of the treatment however their primary healing rate is higher compared with single ulcer group. The results of the study were significantly influenced by the high frequency of loss of follow-up in both groups.
Complications in spinal tumor surgery (review of literature)
Authors: Zaborovskii N. S. , Ptashnikov D. A. , Mikhailov D. A. , Smekalenkov O. A. , Masevnin S. V. , Diusenov D. O. , Kazantsev N. D.
Published: November 2022

Combined anterior and posterior approaches are required in spinal tumor surgery and considered highly invasive. Anatomical and physiological features of the surgical intervention area should be taken into consideration as well. Thus, these criteria reflect the severity of intraoperative complications during the surgical treatment of spinal tumors. The authors reviewed the scientific literature on the frequency and nature of complications in surgical interventions for spinal tumors.The most significant risk factors for intraoperative complications have been considered, the main of which are: the proximity of the location of the main vessels and viscera, the development of postoperative liquorrhea, as well as surgical site infection. Based on the studied information, we presented the methods of prevention and surgical tactics options in complications.
Factors of choosing the financial strategies of Russian households
Authors: MEL'NIKOV Roman M.
Published: November 2022

Subject. The article investigates factors of choosing the household’s financial strategies in modern Russian conditions.
Objectives. The aim is to study the effect of material and socio-psychological characteristics of Russians on their propensity to form savings and attract loans.
Methods. To analyze the factors of financial behavior of Russians, I use databases of the Russian Longitudinal Monitoring Survey. The propensity to form savings and attract loans is estimated, using probit, ordinal probit, and tobit regression. The Big Five Personality Traits model is applied to consider psychological characteristics of the family head in financial decisions.
Results. The estimates confirmed the provisions of the life cycle theory on changing the financial strategy (transition from borrowings when creating the material base of the household at the stage of its formation to savings to finance expenses at retirement age after repayment of home and car loans) as the age of the head of household changes. The precautionary motive effect (formation of financial reserves in anticipation of deteriorating the family's financial situation) was estimated as insignificant.
Conclusions. The psychological characteristics of the family head influence the choice of financial strategy of Russians. Emotionally unstable Russians are not inclined to accept a debt burden, and those characterized by high openness to experience are more wasteful and do not tend to save. I revealed a decrease in the role of social networks in financing household cash gaps and an increase in the role of financial intermediaries in the implementation of financial strategies of Russians.
УПРАВЛІННЯ ОСВІТОЮ В КОНТЕКСТІ НАУКОВИХ ПОГЛЯДІВ М. ДАРМАНСЬКОГО
Authors: Крищук Богдан , Олицька Олена
Published: November 2022

Стаття присвячена висвітленню внеску М. Дарманського у розробку наукових основ теорії та практики управління освітою. Акцентовано увагу на ролі М. Дарманського як ідейного послідовника запровадження ступеневої системи організації освітнього процесу в закладах вищої освіти. У статті охарактеризовано наукові праці М. Дарманського в контексті розкриття сутності управління органами та установами освіти. Автором підкреслена роль М. Дарманського у дослідженні проблем менеджменту в освіті, а також у налагодженні співпраці місцевих органів управління освітою і закладів загальної середньої та вищої освіти. Зауважено, що використання наукового доробку М. Дарманського дасть змогу підвищити ефективність управління освітою і налагодити співпрацю між усіма учасниками освітнього процесу.
Kampanye Ide Khilafah: Studi Manajemen Dakwah Akun Facebook Buletin Dakwah Kaffah
Authors: Jamilah Jamilah , Rafii Muhammad
Published: November 2022

This study sees the management of da'wah in the campaigning caliphate by Kaffah Da'wah Bulletin (BDK) on Facebook. By utilizing primary and secondary data, which were obtained from observation and documentation, the researcher attempted to collect relevant data. Data were analyzed by reduction techniques, data display, and data verification. It concludes that the planning of BDK da'wah on Facebook is to present certain topics and problems in Indonesia with the caliphate system. Social, political, cultural, religious, and educational issues cannot be separated from BDK's manipulation to attract public attention and strengthen the caliphate fighters. This community in carrying out da'wah utilizes the symbols of the Koranic verse about Islam kaffah at the top of writings. In addition, the implementation of da'wah is also carried out through various technological features and popular media; jpeg, mobile, pdf, podcast, audio reading, and WA group. The public's interest with the popular media availability has increased the reputation and supporters of BDK in campaigning for Islamic law and the establishment of an Islamic caliphate. Furthermore, the evaluation of BDK is by reposting all scatter bulletins, this shows the high public interest in the caliphate campaign seen in posts that were redistributed by BDK redistributed about 2500 netizens
PELATIHAN STRUKTURAL DAN PELATIHAN FUNGSIONAL TERHADAP KINERJA PEGAWAI
Authors: Darmayanti Eka , Hifnie Iskandar Z. , . Nur'aeni
Published: November 2022

Pegawai Negeri Sipil sebagai unsur aparatur sipil negara dituntut untuk terus meningkatkan kompetensi dan prestasi kerjanya. Banyak faktor yang dapat mempengaruhi peningkatan kompetensi dan prestasi kerja pegawai diantaranya adalah pengawasan pimpinan, sistem reward dan punishment, motivasi kerja, peran pimpinan dan kesempatan memperoleh pendidikan. Tujuan penelitian dalam tesis ini adalah untuk mengkaji pengaruh pelatihan struktural dan pelatihan fungsional terhadap kinerja pegawai Dinas Tenaga Kerja dan Transmigrasi Kabupaten Lampung Selatan. Jenis penelitian ini adalah penelitian survei dengan jumlah responden sebanyak 41 orang yang dianalisis secara deskriptif maupun kuantitatif. Hasil penelitian bahwa pelatihan struktural berpengaruh positif terhadap kinerja pegawai dengan kontribusi pengaruh sebesar 64,2%. Selanjutnya pelatihan fungsional juga berpengaruh positif terhadap kinerja pegawai dengan kontribusi pengaruh sebesar 62,5%. Hasil analisis regresi variabel pelatihan struktural dan pelatihan fungsional didapat persamaan Y = 3,618 + 0,484 X1 + 0,892X2, serta uji hipotesis secara bersama-sama menunjukkan terdapat pengaruh positif pelatihan struktural dan pelatihan fungsional terhadap kinerja pegawai, dengan kontribusi pengaruh sebesar 72,2% dan sisanya 27,8% dipengaruhi oleh variabel-variabel lain di luar model penelitian.
MANAJEMEN SUMBER DAYA MANUSIA DAN BUDAYA KERJA TERHADAP KUALITAS PELAYANAN PADA DINAS PENDAPATAN DAERAH
Authors: Anom Afandi , Kawulusan Bovie , Devialesti Veni
Published: November 2022

.daya manusia terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah? (2) Apakah ada pengaruh budaya kerja terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah? (3) Apakah ada pengaruh manajemen sumber daya manusia dan budaya kerja terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah? Tujuan yang ingin dicapai dalam penelitian ini adalah: (1) Ingin mengetahui pengaruh manajemen sumber daya manusia terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah. (2) Ingin mengetahui pengaruh budaya kerja terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah. (3) Ingin mengetahui pengaruh manajemen sumber daya manusia dan budaya kerja terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah .Jenis penelitian yang digunakan adalah menggunakan pendekatan survei. Teknik analisis data yang digunakan adalah teknik analisis data kuantitatif. Metode pengumpulan data yang digunakan metode angket, wawancara, observasi dan dokumentasi. Data yang diperoleh dianalisis dengan menggunakan rumus Regresi Linier Berganda dengan menggunakan program SPSS (Statistical Package for Social Science). Berdasarkan hasil penelitian maka disimpulkan bahwa: (1) Ada pengaruh signifikan antara manajemen sumber daya manusia terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah. (2) Ada pengaruh signifikan antara budaya kerja terhadap kualitas pelayanan pada Badan Pendapatan Daerah Kabupaten Lampung Tengah. (3) Berdasarkan hasil uji F dengan perhitungan SPSS dimana nilai F menunjukan nila 9,806. Oleh karena nilai 9,806 > 2,000, berarti ada pengaruh yang signifikan antara manajemen sumber daya manusia dan budaya kerja terhadap kualitas pelayanan Pada Badan Pendapatan Daerah Kabupaten Lampung Tengah.

Kata kunci: Manajemen Sumber Daya Manusia, Budaya Kerja dan Kualitas Pelayanan