bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Diversity of Channelrhodopsins and Their Structure-Function Relationships
Authors: Govorunova Elena G. , Sineshchekov Oleg A. , Spudich John L.
Published: January 2022

Cation and anion channelrhodopsins (CCRs and ACRs, respectively) from phototactic algae have become widely used as genetically encoded molecular tools to control cell membrane potential with light. Recent advances in polynucleotide sequencing, especially in environmental samples, have led to identification of hundreds of channelrhodopsin homologs in many phylogenetic lineages, including non-photosynthetic protists. Only a few CCRs and ACRs have been characterized in detail, but there are indications that ion channel function has evolved within the rhodopsin superfamily by convergent routes. The diversity of channelrhodopsins provides an exceptional platform for the study of structure-function evolution in membrane proteins. Here we review the current state of channelrhodopsin research and outline perspectives for its further development.
Safety and Efficacy of Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of Randomized Controlled Trials
Authors: Ren Junwei , Qian Dongxi , Wu Jiaming , Ni Lingyan , Qian Wei , Zhao Guozheng , Huang Chuanjun , Liu Xing , Zou Yu , Xing Weikang
Published: January 2022

Background

In recent decades, tranexamic acid (TXA) antifibrinolytic therapy before aneurysm clipping or embolization has been widely reported, but its safety and efficacy remain controversial. This meta-analysis evaluated the efficacy and safety of TXA therapy in aneurysmal subarachnoid hemorrhage (aSAH) patients, aiming to improve the evidence-based medical knowledge of treatment options for such patients.

Methods

Pubmed, Web of Science, and Cochrane Library databases were searched up to 1 March 2021 for randomized controlled trials (RCTs). We extracted safety and efficacy outcomes and performed a meta-analysis using the Review Manager software. We performed two group analyses of TXA duration and daily dose.

Results

Ten RCT studies, enrolling a total of 2,810 participants (1,410 with and 1,400 without TXA therapy), matched the selection criteria. In the TXA duration group: TXA did not reduce overall mortality during the follow-up period [RR 1.00 (95% CI 0.81–1.22)]. The overall rebleeding rate in the TXA group was 0.53 times that of the control group, which was statistically significant [RR 0.53 (95% CI 0.39–0.71)]. However, an RR of 0.43 was not statistically significant in the subgroup analysis of short-term therapy [RR 0.43 (95% CI 0.13–1.39)]. The overall incidence of hydrocephalus was significantly higher in the TXA group than in the control group [RR 1.13 (95% CI 1.02–1.24)]. However, the trend was not statistically significant in the subgroup analysis [short-term: RR 1.10 (95% CI 0.99–1.23); long-term: RR 1.22 (95% CI 0.99–1.50)]. Treatment with TXA did not cause significant delayed cerebral ischemia [RR 1.18 (95% CI 0.89–1.56)], and its subgroup analysis showed an opposite and insignificant effect [short-term: RR 0.99 (95% CI 0.79–1.25); long-term: RR 1.38 (95% CI 0.86–2.21)]. Results in the daily dose group were consistent with those in the TXA duration group.

Conclusions

Tranexamic acid does not reduce overall mortality in patients with aSAH, nor does it increase the incidence of delayed cerebral ischemia. Tranexamic acid in treating aSAH can reduce the incidence of rebleeding. However, there is no statisticalsignificance in the ultra-early short-term and low daily dose TXA therapy, which may be due to the lack of relevant studies, and more RCT experiments are needed for further study.

Systematic Review Registration:

https://www.crd.york.ac.uk/PROSPERO/display_record.asp? PROSPERO, identifier: 244079.
Can Endovascular Treatment of Fusiform Intracranial Aneurysms Restore the Healthy Hemodynamic Environment?–A Virtual Pilot Study
Authors: Saalfeld Sylvia , Stahl Janneck , Korte Jana , Miller Marsh Laurel Morgan , Preim Bernhard , Beuing Oliver , Cherednychenko Yurii , Behme Daniel , Berg Philipp
Published: January 2022

Numerous studies assess intracranial aneurysm rupture risk based on morphological and hemodynamic parameter analysis in addition to clinical information such as aneurysm localization, age, and sex. However, intracranial aneurysms mostly occur with a saccular shape located either lateral to the parent artery or at a bifurcation. In contrast, fusiform intracranial aneurysms (FIAs), i.e., aneurysms with a non-saccular, dilated form, occur in approximately 3–13% of all cases and therefore have not yet been as thoroughly studied. To improve the understanding of FIA hemodynamics, this pilot study contains morphological analyses and image-based blood flow simulations in three patient-specific cases. For a precise and realistic comparison to the pre-pathological state, each dilation was manually removed and the time-dependent blood flow simulations were repeated. Additionally, a validated fast virtual stenting approach was applied to evaluate the effect of virtual endovascular flow-diverter deployment focusing on relevant hemodynamic quantities. For two of the three patients, post-interventional information was available and included in the analysis. The results of this numerical pilot study indicate that complex flow structures, i.e., helical flow phenomena and the presence of high oscillating flow features, predominantly occur in FIAs with morphologically differing appearances. Due to the investigation of the individual healthy states, the original flow environment could be restored which serves as a reference for the virtual treatment target. It was shown that the realistic deployment led to a considerable stabilization of the individual hemodynamics in all cases. Furthermore, a quantification of the stent-induced therapy effect became feasible for the treating physician. The results of the morphological and hemodynamic analyses in this pilot study show that virtual stenting can be used in FIAs to quantify the effect of the planned endovascular treatment.
Profiling Phenolic Composition in Pomegranate Peel From Nine Selected Cultivars Using UHPLC-QTOF-MS and UPLC-QQQ-MS
Authors: Man Guowei , Xu Lei , Wang Yongtao , Liao Xiaojun , Xu Zhenzhen
Published: January 2022

Pomegranate is widely cultivated across China, and the phenolics in its peel are principal components associated with health benefits. Ultra-high performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer (UHPLC-QTOF-MS) and ultra-performance liquid chromatography coupled to a triple quadrupole mass spectrometer (UPLC-QQQ-MS) were used in this study, aiming at profiling the total phenolic composition in pomegranate peel from nine selected cultivars in 7 production areas. Sixty-four phenolic compounds were identified or annotated, and 23 of them were firstly reported in pomegranate peel. Principal component analysis (PCA) plots show differences and similarities of phenolics among nine cultivars. Furthermore, 15 phenolic compounds were quantified with the standards, and punicalagin, ellagic acid, gallocatechin, punicalin, catechin, and corilagin were found to be dominant. Punicalagin weighed the highest content (28.03–104.14 mg/g). This study can provide a deeper and more detailed insight into the phenolic composition in pomegranate peel and facilitate the health-promoting utilization of phenolics.
Neck Management in cT1N0 Tongue Squamous Cell Carcinoma as Determined by Sonographic Depth of Invasion
Authors: Wu Yao , Zhang Xu , Dai Liyuan , Fang Qigen , Du Wei
Published: January 2022

Objectives

To compare the oncologic outcomes in patients with cT1N0 tongue squamous cell carcinoma (SCC) who underwent different neck management strategies stratified by sonographic depth of invasion (DOI).

Methods

The included patients were retrospectively enrolled, and divided into two groups: observation (OBS) and elective neck dissection (END). The regional control (RC) and disease-specific survival (DSS) rates were compared and stratified by sonographic DOI.

Results

The mean sonographic and pathologic DOIs were 3.8 and 3.7 mm, respectively; the two DOIs were significantly correlated (Spearman correlation coefficient 0.974. p <0.001). In patients with sonographic DOI <4.0 mm, the 5-year RC rates were 73 and 89% in the OBS and END groups, respectively, and were not significantly different. However, in patients with sonographic DOI ≥4.0 mm, the 5-year RC rate was significantly different between the OBS (57%) and END (80%) groups (p = 0.031). In patients with sonographic DOI <4.0 mm, the 5-year DSS rates were 79 and 89% in OBS and END groups, respectively, and were not significantly different. However, in patients with sonographic DOI ≥4.0 mm, the 5-year DSS rate was significantly different between the OBS (67%) and END (86%) groups (p = 0.033).

Conclusions

Sonographic DOI was notably correlated with pathologic DOI. Moreover, there was a significant survival difference between the OBS and END groups in cT1N0 tongue SCC patients with sonographic DOI ≥4.0 mm but not in those with sonographic DOI <4.0 mm. Our study provides a useful method to aid decision-making in the clinical setting for this patient group.
Identification of a Hypoxia-Related Gene Model for Predicting the Prognosis and Formulating the Treatment Strategies in Kidney Renal Clear Cell Carcinoma
Authors: Ning Xiang-hui , Li Ning-yang , Qi Yuan-yuan , Li Song-chao , Jia Zhan-kui , Yang Jin-jian
Published: January 2022

Purpose

The present study aimed to establish a hypoxia related genes model to predict the prognosis of kidney clear cell carcinoma (KIRC) patients using data accessed from The Cancer Genome Atlas (TCGA) database and International Cancer Genome Consortium (ICGC) database.

Methods

Patients’ data were downloaded from the TCGA and ICGC databases, and hypoxia related genes were accessed from the Molecular Signatures Database. The differentially expressed genes were evaluated and then the differential expressions hypoxia genes were screened. The TCGA cohort was randomly divided into a discovery TCGA cohort and a validation TCGA cohort. The discovery TCGA cohort was used for constructing the hypoxia genes risk model through Lasso regression, univariate and multivariate Cox regression analysis. Receiver operating characteristic (ROC) curves were used to assess the reliability and sensitivity of our model. Then, we established a nomogram to predict the probable one-, three-, and five-year overall survival rates. Lastly, the Tumor Immune Dysfunction and Exclusion (TIDE) score of patients was calculated.

Results

We established a six hypoxia-related gene prognostic model of KIRC patients in the TCGA database and validated in the ICGC database. The patients with high riskscore present poorer prognosis than those with low riskscore in the three TCGA cohorts and ICGC cohort. ROC curves show our six-gene model with a robust predictive capability in these four cohorts. In addition, we constructed a nomogram for KIRC patients in the TCGA database. Finally, the high risk-group had a high TIDE score than the patients with low riskscore.

Conclusions

We established a six hypoxia-related gene risk model for independent prediction of the prognosis of KIRC patients was established and constructed a robust nomogram. The different riskscores might be a biomarker for immunotherapy strategy.
Association Between NT-proBNP and Prolonged Length of Stay in Hospital Among Preterm Infants Born at 28–31 Weeks' Gestation
Authors: Ge Jian , Luo Chenghan , Lei Mengyuan , Shi Zanyang , Cheng Xinru , Zhao Min , Zhao Yanting , Song Min , Ding Wenqian , Wang Mengmeng , Cao Wenjun , Mao Fengxia , Han Suge , Xu Qianya , Wang Junbo , Qin Haoqi , Wang Li , Zhang Qian
Published: January 2022

Objective

In the early life of preterm infants, the relationship between heart function and length of hospitalization is unclear. This study aims to examine the association between serum NT-proBNP level on the 7th day (NT-proBNP7) after birth and length of hospitalization among preterm infants.

Methods

A retrospective cohort study was conducted. Patients included 709 preterm infants born at 28–31 weeks' gestational age (GA) admitted to the NICU of the First Affiliated Hospital of Zhengzhou University between December 20, 2016, to April 31, 2021. Main outcome: Late discharge (postmenstrual age at discharge was in the fourth quartile (highest) among infants born at the same GA). Exposure factor: NT-proBNP7.

Results

We observed increased prevalence ratios for late discharge among the tertile of logarithm of NT-proBNP7 level (LnNT-proBNP7) which was positive. Compared with the lowest tertile, infants in the highest tertile of LnNT-proBNP7 had an 8.4-fold increased probability of late discharge, and the results were consistent for the subgroups. Next, a non-linear (S-shaped) relationship between LnNT-proBNP7 and late discharge was observed, whose turning points were 7.5 and 9. The effect sizes and the confidence intervals on the left of the first turning point, between two turning points and on the right of the second turning point, were 0.6 (95% CI, 0.2–1.6), 5.0 (95% CI, 2.4–10.6), and 1.1 (95% CI, 0.2–6.1), respectively. In addition, the prevalence of BPD, NEC, nosocomial infection, or any of them was highest in the group of LnNT-proBNP7 ≥ 9, lowest in the group of LnNT-proBNP7 < 7.5.

Conclusion

Higher NT-proBNP7 levels were associated with longer hospitalization. The relationship between LnNT-proBNP7 and late discharge was S-shaped. LnNT-proBNP7 was positively related with late discharge when LnNT-proBNP7 was between 7.5 and 9.
Cost Efficacy of Rapid Whole Genome Sequencing in the Pediatric Intensive Care Unit
Authors: Sanford Kobayashi Erica , Waldman Bryce , Engorn Branden M. , Perofsky Katherine , Allred Erika , Briggs Benjamin , Gatcliffe Chelsea , Ramchandar Nanda , Gold Jeffrey J. , Doshi Ami , Ingulli Elizabeth G. , Thornburg Courtney D. , Benson Wendy , Farnaes Lauge , Chowdhury Shimul , Rego Seema , Hobbs Charlotte , Kingsmore Stephen F. , Dimmock David P. , Coufal Nicole G.
Published: January 2022

The diagnostic and clinical utility of rapid whole genome sequencing (rWGS) for critically ill children in the intensive care unit (ICU) has been substantiated by multiple studies, but comprehensive cost-effectiveness evaluation of rWGS in the ICU outside of the neonatal age group is lacking. In this study, we examined cost data retrospectively for a cohort of 38 children in a regional pediatric ICU (PICU) who received rWGS. We identified seven of 17 patients who received molecular diagnoses by rWGS and had resultant changes in clinical management with sufficient clarity to permit cost and quality adjusted life years (QALY) modeling. Cost of PICU care was estimated to be reduced by $184,846 and a total of 12.1 QALYs were gained among these seven patients. The total cost of rWGS for patients and families for the entire cohort (38 probands) was $239,400. Thus, the net cost of rWGS was $54,554, representing $4,509 per QALY gained. This quantitative, retrospective examination of healthcare utilization associated with rWGS-informed medicine interventions in the PICU revealed approximately one-third of a QALY gained per patient tested at a cost per QALY that was approximately one-tenth of that typically sought for cost-effective new medical interventions. This evidence suggests that performance of rWGS as a first-tier test in selected PICU children with diseases of unknown etiology is associated with acceptable cost-per-QALY gained.
Different Types of Screen Behavior and Depression in Children and Adolescents
Authors: Kidokoro Tetsuhiro , Shikano Akiko , Tanaka Ryo , Tanabe Kosuke , Imai Natsuko , Noi Shingo
Published: January 2022

The purpose of this study was to examine the associations between different types of screen behavior and depression, taking into account exercise and sleep among children and adolescents. A total of 23,573 Japanese children and adolescents (aged 8–15 years) participated in this cross-sectional study. Different types of screen behavior, weekly exercise time, sleep duration, and prevalence of depression were assessed using a questionnaire. Independent associations between various types of screen behavior and prevalence of depression were examined using logistic regression analyses after adjusting for age, school, sleep duration, exercise time, and other screen behavior types. A two-way analysis of covariance was conducted to examine whether exercise and sleep can attenuate the negative effects of screen behavior. The associations between screen behavior and depression varied by screen behavior types and participant characteristics. More time spent engaging in newer types of screen behavior, including social media, online games, and online videos, was associated with a higher prevalence of depression. In contrast, more time spent on TV was associated with a lower prevalence of depression. Sufficient exercise can lower the prevalence of depression, regardless of the length of time and content of the screen, and its associations were particularly significant for junior high school girls. Sleep was not associated with the prevalence of depression among any participant group except elementary school boys. Our findings suggest that age- and sex-specific intervention strategies that also consider screen-based behavior can effectively lower the risk of depression in children and adolescents.
Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity
Authors: Ma Wenxian , Jin Qiaoyan , Guo Haiqin , Han Xinpeng , Xu Lingbin , Lu Shemin , Wu Changgui
Published: January 2022

Metformin has been involved in modulating inflammatory state and inhibiting cell proliferation and angiogenesis. This study aimed to determine whether metformin alleviates airway inflammation and remodeling of experimental allergic asthma and elucidate the underlying mechanism. We sensitized and challenged mice with ovalbumin (OVA) to induce allergic asthma. During the challenge period, metformin was administered by intraperitoneal injection. By histopathological and immunohistochemical analyses, metformin-treated mice showed a significant alleviation in airway inflammation, and in the parameters of airway remodeling including goblet cell hyperplasia, collagen deposition and airway smooth muscle hypertrophy compared to those in the OVA-challenged mice. We also observed elevated levels of multiple cytokines (IL-4, IL-5, IL-13, TNF-α, TGF-β1 and MMP-9) in the bronchoalveolar lavage fluid, OVA-specific IgE in the serum and angiogenesis-related factors (VEGF, SDF-1 and CXCR4) in the plasma from asthmatic mice, while metformin reduced all these parameters. Additionally, the activity of 5′-adenosine monophosphate-activated protein kinase a (AMPKα) in the lungs from OVA-challenged mice was remarkably lower than control ones, while after metformin treatment, the ratio of p-AMPKα to AMPKα was upregulated and new blood vessels in the sub-epithelial area as evidenced by CD31 staining were effectively suppressed. These results indicate that metformin ameliorates airway inflammation and remodeling in an OVA-induced chronic asthmatic model and its protective role could be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
Deciphering the Mechanism of Bushen Huoxue Decotion on Decidualization by Intervening Autophagy via AMPK/mTOR/ULK1: A Novel Discovery for URSA Treatment
Authors: Zhao Xiaoxuan , Jiang Yuepeng , Ren Jiajie , Wang Yunrui , Zhao Yan , Feng Xiaoling
Published: January 2022

Impaired decidualization was recognized as one of the crucial pathomechanisms accounting for unexplained recurrent spontaneous abortion (URSA). Currently, the exact molecular mechanism and targeted clinical decision are still in exploration. Bushen Huoxue decoction (BSHXD) has previously been proved effective in treating URSA, but its mechanism remains to be elucidated. This study aimed to explore the regulation mechanism of BSHXD in decidualization from its intervention in autophagy so as to rationalize its potential as a novel therapeutic regime for URSA. Decidua tissues were collected from patients with URSA and healthy pregnant women who underwent legal terminations for non-medical reasons at the first trimester. Besides, cell line T-hESCs was utilized to establish induced decidualization model, and were randomly divided into ESC group, DSC group, 3-MA group, AMPK siRNA group, scrambled siRNA group and AMPK siRNA + BSHXD group. Transmission electron microscopy, Monodansylcadaverine (MDC) assay, qRT-PCR, immunohistochemistry, immunofluorescence and Western blotting were used to evaluate the level of decidualization, autophagy and activation of AMPK signaling pathway in decidua tissues and cell experiments. Experiments on decidua tissues showed that decidualization was impaired in URSA with inhibited autophagy. Besides, pAMPK T172 and pULK1 S556 were decreased, and pmTOR S2448 and pULK1 S757 were increased. Cell experiments showed that the level of autophagy increased during induced decidualization, but when autophagy was inhibited, decidualization was impaired. In addition, AMPK/mTOR/ULK1 affected decidualization by mediating autophagy, and BSHXD improved decidualization through this mechanism. In conclusion, this study clarified that the inhibition of autophagy mediated by AMPK/mTOR/ULK1 was associated with impaired decidualization, and the intervention of BSHXD on this pathological process may be a vital mechanism for its treatment of URSA. This study laid the foundation for further research and application of BSHXD.
Studyholism: A New Obsessive-Compulsive Related Disorder? An Analysis of Its Association With Internalizing and Externalizing Features
Authors: Loscalzo Yura , Giannini Marco
Published: January 2022

Studyholism (or obsession toward study) is a new potential obsessive-compulsive (OCD)-related disorder recently introduced in the literature. According to its theorization, there are two types of Studyholic: Engaged and Disengaged Studyholics, which are characterized, respectively, by high and low levels of Study Engagement. This study aims to shed light on the role of internalizing and externalizing features as antecedents and outcomes of Studyholism and Study Engagement. Moreover, it aims to analyze the differences in psychopathology and sensation seeking between students demonstrating Disengaged and Engaged Studyholism. We performed four path analyses, MANOVAs, and Mann–Whitney tests on 1,223 Italian college students (Mage = 22.56 ± 3.53). Among the main findings, Studyholism is associated with psychological and academic impairment, while Study Engagement predicts better mental health and academic functioning; though, the β values are lower for Study Engagement. Moreover, Studyholism is positively predicted by internalizing symptoms and negatively predicted by externalizing variables. Finally, students showing Engaged Studyholism have lower levels of obsessive-compulsive symptoms than those demonstrating Disengaged Studyholism. In conclusion, this study shows the critical importance of implementing preventive interventions aimed at reducing Studyholism levels in college students. Moreover, it provides support to the conceptualization of problematic overstudying as a new potential OCD-related disorder and to the value of distinguishing between Engaged and Disengaged Studyholics for tailored clinical interventions. Finally, it highlights the need to use two different theorizations and operationalizations for problematic overworking and overstudying. However, the literature on problematic overstudying is too scant to reach any firm conclusion. Hence, future studies should deepen the analysis of problematic overstudying, possibly using longitudinal designs, to unveil its internalizing and/or externalizing nature.
Adolescents’ Filial Piety Attitudes in Relation to Their Perceived Parenting Styles: An Urban–Rural Comparative Longitudinal Study in China
Authors: Lin Li , Wang Qian
Published: January 2022

The Dual Filial Piety Model (i.e., the model of reciprocal and authoritarian filial piety) offers a universally applicable framework for understanding essential aspects of intergenerational relations across diverse cultural contexts. The current research aimed to examine two important issues concerning this model that have lacked investigation: the roles of parental socialization (i.e., authoritative and authoritarian parenting styles) and social ecologies (i.e., urban vs. rural settings that differ in levels of economic development and modernization) in the development of reciprocal and authoritarian filial piety attitudes. To this end, a two-wave short-term longitudinal survey study was conducted among 850 early adolescents residing in urban (N = 314, 49.4% females, mean age = 13.31 years) and rural China (N = 536, 45.3% females, mean age = 13.72 years), who completed questionnaires twice, 6 months apart, in the spring semester of grade 7 and the fall semester of grade 8. Multigroup path analyses revealed bidirectional associations over time between perceived parenting styles and adolescents’ filial piety attitudes, with both similarities and differences in these associations between urban and rural China. In both settings, perceived authoritative parenting predicted increased reciprocal filial piety 6 months later, whereas perceived authoritarian parenting predicted reduced reciprocal filial piety among urban (but not rural) adolescents over time. Moreover, in both settings, reciprocal filial piety predicted higher levels of perceived authoritative parenting and lower levels of perceived authoritarian parenting 6 months later, with the latter effect being stronger among urban (vs. rural) adolescents. Adolescents’ perceived parenting styles did not predict their authoritarian filial piety over time; however, authoritarian filial piety predicted higher levels of perceived authoritative parenting (but not perceived authoritarian parenting) 6 months later in both settings. The findings highlight the roles of transactional socialization processes between parents and youth as well as social ecologies in the development of filial piety, thus advancing the understanding of how the universal human motivations underlying filial piety may function developmentally across different socioeconomic and sociocultural settings.
Can Housing Assets Affect the Chinese Residents’ Willingness to Pay for Green Housing?
Authors: Wu Qian , Zheng Ziyang , Li Wenbo
Published: January 2022

As the development trend of the future housing field, green housing is an effective way to reduce pollution, save energy, and promote industrial upgrading. At the same time, the green house is of great significance to change the development mode of the construction industry and promote the sustainable development of the social economy. This study proposes a comprehensive research model to examine the influencing mechanism of residents’ intention to purchase green buildings. The proposed model is empirically tested using data collected from 1,338 urban residents in China. Based on logit, probit, and ivprobit models, factors such as personal characteristics, housing price, and the number of real estate ownership are selected to conduct empirical analysis and mechanism analysis on willingness that affects consumers’ purchase of green houses. The results show that housing assets significantly affect the willingness of householders to pay for green houses. The more houses they own, the higher their willingness to pay for a green house will be. Similarly, if the housing prices are higher, householders are more willing to buy a green house. The amount of housing assets will affect the willingness of householders to pay for green housing through the way of individual happiness. In terms of the characteristics of the householder, if the householder is more educated, unmarried, his willingness to buy a green house will be stronger, and owning housing assets may affect the individual happiness due to the housing wealth effect brought by rising housing prices. People with more housing assets are more likely to have the happiness brought by higher wealth, which may affect the purchase intention of householders.
The Generative Mechanism of Boomerang Intention: From the Perspective of Legacy Identification
Authors: Tian Zehui , Yuan Qinghong , Qian Shanshan , Liu Yanyan
Published: January 2022

Boomerang employment has become an increasingly significant third way to obtain employees, yet little research has focused on why does ex-employee want to come back. Drawing from social identity theory, we propose that legacy identification could increase boomerang intention and both perceived corporate prestige and psychological contract violation could affect boomerang intention through legacy identification. The cooperative relationship between the former organization and the current organization could enhance these effects. Results from a two-time points survey of 202 Chinese employees showed that legacy identification could increase boomerang intention, perceived corporate prestige could increase boomerang intention via legacy identification, psychological contract violation could decrease boomerang intention via legacy identification. Besides, the positive effect of legacy identification on boomerang intention, the positive indirect effect of corporate prestige on boomerang intention via legacy identification, and the negative indirect effect of psychological contract violation on boomerang intention via legacy identification are all stronger when there is a cooperative relationship. Theoretical and practical implications are discussed.
PERMA+4: A Framework for Work-Related Wellbeing, Performance and Positive Organizational Psychology 2.0
Authors: Donaldson Stewart I. , van Zyl Llewellyn Ellardus , Donaldson Scott I.
Published: January 2022

A growing body of empirical evidence suggests that positive emotions, engagement, relationships, meaning, and accomplishments (PERMA) may be a robust framework for the measurement, management and development of wellbeing. While the original PERMA framework made great headway in the past decade, its empirical and theoretical limitations were recently identified and critiqued. In response, Seligman clarified the value of PERMA as a framework for and not a theory of wellbeing and called for further research to expand the construct. To expand the framework into organizational contexts, recent meta-analyses and systematic literature reviews showed that physical health, mindset, physical work environments and economic security could be seen as essential contextually relevant building blocks for work-related wellbeing and are therefore prime candidates to expand the PERMA framework for use within organizational contexts. Through expanding the original PERMA framework with these four factors, a new holistic approach to work-related wellbeing and work performance was born: the PERMA+4. As such, the purpose of this brief perspective paper is to provide a conceptual overview of PERMA+4 as holistic framework for work-related wellbeing and work performance which extends beyond the predominant componential thinking of the discipline. Specifically, we aim to do so by providing: (1) a brief historical overview of the development of PERMA as a theory for wellbeing, (2) a conceptual overview of PERMA+4 as a holistic framework for work-related wellbeing and work performance, (3) empirical evidence supporting the usefulness of PERMA+4, and (4) charting a course for the second wave of positive organizational psychological research.
Influence of Stimulus Size on Simultaneous Chromatic Induction
Authors: Kanematsu Tama , Koida Kowa
Published: January 2022

Chromatic induction is a major contextual effect of color appearance. Patterned backgrounds are known to induce strong chromatic induction effects. However, it has not been clarified whether the spatial extent of the chromatic surrounding induces a chromatic contrast or assimilation effects. In this study, we examined the influence of the width of a center line and its flanking white contour on the color appearance when the line was surrounded by chromatic backgrounds. A strong color shift was observed when the center line was flanked by white contours with the L/M- and S-cone chromatic backgrounds. There was a difference between the optimal widths of the center line and the contour for the shift in color appearance for the L/M-cone chromaticity (0.9 and 1.1–1.7 min, respectively) and the S-cone chromaticity (8.2–17.5 and 0.9–2.5 min, respectively). The optimal width of the center line for the L/M-cone was finer than the resolution-limit width of the chromatic contrast sensitivity and coarser than that of the luminance contrast sensitivity. Thus, the color appearance of the center line could be obtained by integrating broad chromatic information and fine luminance details. Due to blurring and chromatic aberrations, the simulated artifact was large for the darker center line and S-cone background, thus suggesting that the artifact could explain the luminance dependency of the induction along the S-cone chromaticity. Moreover, the findings of this study reveal that the dominant factor of the color shift is neural instead of optical.
Group-Based Online Job Interview Training Program Using Virtual Robot for Individuals With Autism Spectrum Disorders
Authors: Kumazaki Hirokazu , Yoshikawa Yuichiro , Muramatsu Taro , Haraguchi Hideyuki , Fujisato Hiroko , Sakai Kazuki , Matsumoto Yoshio , Ishiguro Hiroshi , Sumiyoshi Tomiki , Mimura Masaru
Published: January 2022

The rapid expansion of online job interviews during the COVID-19 pandemic is expected to continue after the pandemic has subsided. These interviews are a significant barrier for individuals with autism spectrum disorders (ASD). There is little evidence-based training for online job interviews for individuals with ASD, and the development of new trainings is expected. In an effort to facilitate online job interview skill acquisition for individuals with ASD, we developed a group-based online job interview training program using a virtual robot (GOT). In GOT, the interviewer and interviewee are projected as virtual robots on the screen. Five participants were grouped and performed the role of interviewee, interviewer, and evaluator. The participants performed all roles in a random order. Each session consisted of a first job interview session, feedback session, and second job interview session. The participants experienced 25 sessions. Before and after GOT, the participants underwent a mock online job interview with a human professional interviewer (MOH) to evaluate the effect of GOT. In total, 15 individuals with ASD took part in the study. The GOT improved self-confidence, motivation, the understanding of others' perspectives, verbal competence, non-verbal competence, and interview performance scores. There was also a significant increase in the recognition of the importance of the point of view of interviewers and evaluators after the second MOH compared to after the first MOH. Using a VR robot and learning the importance of interview skills by experiencing other perspectives (i.e., viewpoint of interviewer and evaluator) may have sustained their motivation and enabled greater self-confidence. Given the promising results of this study and to draw definitive conclusions regarding the efficacy of virtual reality (VR) robots for mock online job interview training, further studies with larger, more diverse samples of individuals with ASD using a longitudinal design are warranted.
Perceived Social Support Partially Mediates the Impact of Temperament and Character on Postpartum Depression
Authors: Nakamura Yukako , Takahashi Nagahide , Yamauchi Aya , Morikawa Mako , Okada Takashi , Ozaki Norio
Published: January 2022

Introduction

Temperament and character of pregnant women, especially harm avoidance (HA) and self-directedness (SD) have been identified as risk factors for postpartum depression, in addition to poor social support. However, the relationship between these personality traits and social support for depressive symptoms after delivery has not been examined.

Methods

Data were extracted from a prospective cohort survey on pregnant women conducted in Nagoya, Japan that included the Temperament and Character Inventory (TCI), the Social Support Questionnaire (J-SSQ), and the Edinburgh Postnatal Depression Scale (EPDS) at approximately week 25 and 1 month postpartum. A mediation analysis using structural equation modeling (SEM) was used to test if social support in pregnancy is a mediator between personality traits and postpartum depressive symptoms.

Results

Thousand five hundred and fifty-nine women were included in the analysis. Both harm avoidance and SD were significantly associated with depressive symptoms (total effect: β [SE], 0.298 [0.041], P < 0.001 for harm avoidance; total effect: β [SE], −0.265 [0.067], P < 0.001 for SD). Mediation analysis showed that the effect of harm avoidance on depressive symptoms was partially mediated by low social support (direct effect: β [SE], 0.193 [0.004], P < 0.001; indirect effect: β [SE], 0.082 [0.034], P = 0.015). Self-directedness on depressive symptoms was not found to be mediated by low social support.

Conclusion

Results indicate that poor social support worsens depressive symptoms in women with high HA during pregnancy. Limitations include a possible selection bias due to the limited target facilities; most variables being evaluated based on self-report questionnaires, and different number of samples available for analysis between harm avoidance and SD.
Analysis on the Economic Recovery in the Post-COVID-19 Era: Evidence From China
Authors: Jiang Dayang , Wang Xinyu , Zhao Rui
Published: January 2022

As a major public health emergency, the COVID-19 pandemic has had a huge impact on economies all over the world. The experience of post-COVID-19 economic recovery is of great significance for achieving sustainable and high-quality economic development. Taking the economic development of China as an example, based on the theory of resilient economy and related measurement methods, this article selects five major indicators that are generally recognized as closely connected with economic resilience to construct a system of economic resilience indicators. In addition, the autoregressive integrated moving average (ARIMA) model is used to predict gross domestic product (GDP) under the scenario of no epidemic. The actual value of China's GDP is compared with the predicted value in the absence of the epidemic, verifying that strong economic resilience plays an important role in the country's economic response to major shocks. Based on the results, policy recommendations are made for countries to strengthen their economic resilience in the postepidemic era.
Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains
Authors: Stanton Jo-Ann L. , O'Brien Rory , Hall Richard J. , Chernyavtseva Anastasia , Ha Hye Jeong , Jelley Lauren , Mace Peter D. , Klenov Alexander , Treece Jackson M. , Fraser John D. , Clow Fiona , Clarke Lewis , Su Yongdong , Kurup Harikrishnan M. , Filichev Vyacheslav V. , Rolleston William , Law Lee , Rendle Phillip M. , Harris Lawrence D. , Wood James M. , Scully Thomas W. , Ussher James E. , Grant Jenny , Hore Timothy A. , Moser Tim V. , Harfoot Rhodri , Lawley Blair , Quiñones-Mateu Miguel E. , Collins Patrick , Blaikie Richard
Published: January 2022

The rapid global rise of COVID-19 from late 2019 caught major manufacturers of RT-qPCR reagents by surprise and threw into sharp focus the heavy reliance of molecular diagnostic providers on a handful of reagent suppliers. In addition, lockdown and transport bans, necessarily imposed to contain disease spread, put pressure on global supply lines with freight volumes severely restricted. These issues were acutely felt in New Zealand, an island nation located at the end of most supply lines. This led New Zealand scientists to pose the hypothetical question: in a doomsday scenario where access to COVID-19 RT-qPCR reagents became unavailable, would New Zealand possess the expertise and infrastructure to make its own reagents onshore? In this work we describe a review of New Zealand's COVID-19 test requirements, bring together local experts and resources to make all reagents for the RT-qPCR process, and create a COVID-19 diagnostic assay referred to as HomeBrew (HB) RT-qPCR from onshore synthesized components. This one-step RT-qPCR assay was evaluated using clinical samples and shown to be comparable to a commercial COVID-19 assay. Through this work we show New Zealand has both the expertise and, with sufficient lead time and forward planning, infrastructure capacity to meet reagent supply challenges if they were ever to emerge.
Face Masks Use and Its Role in Restraining the Spread of COVID-19 Pandemic in Saudi Arabia: Knowledge, Attitude, and Practices Based Cross-Sectional Study
Authors: Meo Sultan Ayoub , Alqahtani Sara A. , Aljedaie Ghada M. , Binmeather Fatimah S. , AlRasheed Renad A. , Albarrak Raghad M.
Published: January 2022

Face masks (FM) play a role in limiting the spread of viral infections; despite this, their role is influenced by the population's adherence to wearing the FM. However, the impact on the effectiveness of the FM is variable in various communities. This study aimed to investigate the knowledge, attitude, and practices toward FM use during COVID-19 in Saudi Arabia. This observational “cross-sectional questionnaire-based study was conducted in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.” The data was collected using an online questionnaire survey from September 8–21, 2021, during the COVID-19 pandemic. The questionnaire was distributed via social media platforms to assess knowledge, attitude, and practices using single choice questions and a five-point Likert scale. Among 1,356, respondents' the rate was 678 (50%), 207 (30.5%) were males and 471 (69.5%) females. Among the participants, Saudi citizens were (649; 95.7%), with University education (502; 74%) and were mostly (368; 54.3%) between 16 and 24 years of age. The participants (384; 56.6%, p < 0.001) had good knowledge about face masks, and more than half of the respondents, 531 (78.3%) (p < 0.001), showed a positive attitude. Most of the respondents (477, 70.2%) believed that everyone could use the face mask to minimize the spread of the disease; however (111; 16.4%) reported that they would not wear a face mask if the government did not recommend wearing it in public places during the COVID-19 pandemic. Saudi citizens have above-average knowledge and optimistic attitudes toward using face masks during the COVID-19 pandemic. The community is convinced about the face masks and believes that face masks play a predominant role in limiting the spread of SARS-CoV-2.
Implementing Systemic Innovation Strategies for a More Sustainable Future: The Case of Three Overseas Countries and Territories
Authors: Toffanin Renato , Jezic von Gesseneck Milan
Published: January 2022

Addressing sustainability issues requires a radical systemic change across multiple dimensions, including policy, culture, and civil society. This also implies that no blueprints for governing critical sustainability issues both at the local and global levels exist. As a result, rather than imposing decisions, policymakers should engage in a learning process. In this paper, we contend that appropriate policies should be developed and fine-tuned over time through a collective, social endeavour. To support this hypothesis, the study focuses on a shared methodology based on backcasting, a specific type of foresight, to facilitate policy learning (and thus policymaking) within a wide range of territories, regardless of their wealth, geographic characteristics and internal political organisation. This methodology was developed over a three-year period as part of the Territorial Strategies for Innovation (TSI) programme. The overall objective of our assignment was to build capacity and raise awareness within the EU's Overseas Countries and Territories about policymaking and implementation of innovative approaches to development. This innovative approach, which incorporates a systemic innovation perspective, highlights new options and opportunities for adopting and implementing adequate policies to positively impact sustainable development and long-term transformative change. Using empirical examples from Anguilla, Curaçao, and New Caledonia, the paper focuses on the learning processes required to deal with complexity and uncertainty in these remote territories. We conclude by discussing the potential implications of this foresight approach for the sustainable development and transformation of other less-favoured regions and territories.
Radiometric Stability Assessment of the DSCOVR EPIC Visible Bands Using MODIS, VIIRS, and Invariant Targets as Independent References
Authors: Haney Conor , Doelling David R. , Su Wenying , Bhatt Rajendra , Gopalan Arun , Scarino Benjamin
Published: January 2022

The DSCOVR mission was designed to take advantage of the first Lagrangian position (L1) to continuously observe the Earth sunlit disk. To facilitate EPIC V03 data product validation and fusion, the EPIC V03 navigation and calibration stability is assessed. The Aqua-MODIS, NPP-VIIRS, and N20-VIIRS based radiometric scaling factors are also provided. The V03 navigation error was 15.5 km, a 50% improvement over V02 and within what can be achieved by an objective image alignment algorithm. Both the navigation accuracy and precision were improved in V03 and were found to be comparable across all EPIC visible channels. The all-sky tropical ocean and deep convective cloud ray-matched MODIS- and VIIRS-referenced EPIC inter-calibration gains are within 0.4% of one-another, and are also within 0.4% of a previous study’s NPP-VIIRS-referenced gains. The inter-calibration study reveals that EPIC bands 5 and 6 degraded mostly within the first year of operation and becoming stable thereafter, whereas bands 7 and 10 were stable during the 6-years record. The capability of the V03 navigation allowed EPIC stability to be monitored using DCC and Libya-4 invariant targets. The EPIC V03 calibration was mostly stable within 0.3% over the 6-years record, as determined from inter-calibration and invariant target monitoring methods. Remarkably, both the DCC- and Libya-4-based methods were able to confirm the stability of the E-8 and E-9 oxygen absorptions—a stability comparable to that of the E-7 and E-10 reference bands. No significant change in the navigation accuracy or calibration stability was observed after the DSCOVR 2019 safe mode incident. The impressive stability of the DSCOVR EPIC L1B V03 channel radiances can greatly benefit the Earth remote sensing community by providing diurnally complete daytime radiative flux and environmental retrievals for future sensors located at L1.
Critical Transitions in Ecosystems and Society. The Contribution of Sociological Systems Theory to the Analysis of Socio-Environmental Transformations
Authors: Mascareño Aldo
Published: January 2022

The theory of critical transitions and the theory of self-referential social systems are two well-established theories in the ecosystem and sociological research respectively. A dialogue between them may offer new insights on the complex articulation of the nature and society nexus in socio-environmental transformations. By means of the conceptual reconstruction of both theories and drawing on relevant literature of social-ecological research, in this article, I argue that systems theory can contribute to the theory of critical transitions with a robust concept of communication that accounts for the relevance of semantics and social structures, the production of communicative locks, and the identification of early warning signals of social-ecological transitions in communication. On the other hand, the theory of critical transitions provides systems theory with both a refined concept of crisis as critical transition and the technical tools for empirical research. The article concludes that the dialogue between the science of ecosystems and the science of society is not an intellectual exercise but a form of increasing the correspondence between social-ecological transitions and our explanations and interventions in this domain.