bluuebunny/crossref_metadata_2025 huggingface dataset:
An Augmented Reality Mobile App (Easypod AR) as a Complementary Tool in the Nurse-Led Integrated Support of Patients Receiving Recombinant Human Growth Hormone: Usability and Validation Study
Authors: Baños Rosa Maria , Peltonen Laura-Maria , Martin Blaine , Koledova Ekaterina
Published: April 2023

Background

Children with growth hormone deficiency face the prospect of long-term recombinant human growth hormone (r-hGH) treatment requiring daily injections. Adherence to treatment is important, especially at treatment initiation, to achieve positive health outcomes. Historically, telenursing services embedded in patient support programs (PSPs) have been a valid approach to support r-hGH treatment initiation and patient education and facilitate adherence by identifying and optimizing appropriate injection techniques. The development of mobile phones with augmented reality (AR) capabilities offers nurses new tools to support patient education.

Objective

To investigate experiences among nurses of a new mobile phone app developed to support patient training with a phone-based PSP for r-hGH treatment.

Methods

In 2020, the Easypod AR mobile app was launched to support nurse-driven telehealth education for patients initiating r-hGH therapy with the Easypod electromechanical auto-injector device. Nurses who were part of PSPs in countries where the Easypod AR app had been launched or where training was provided as part of an anticipated future launch of the app were invited to participate in an online survey based on the Mobile App Rating Scale to capture their feedback after using the app.

Results

In total, 23 nurses completed the online questionnaire. They positively rated the quality of the app across multiple dimensions. The highest mean scores were 4.0 for engagement (ie, adaptation to the target group; SD 0.74), 4.1 (SD 0.79) for functionality (navigation) and 4.1 (SD 0.67) for aesthetics (graphics). Responses indicated the potential positive impact of such a tool on enhancing patient education, patient support, and communication between patients and PSP nurses. Some participants also suggested enhancements to the app, including gamification techniques that they felt have the potential to support the formation of positive treatment behaviors and habits.

Conclusions

This study highlights the potential for new digital health solutions to reinforce PSP nurse services, including patient education. Future studies could explore possible correlations between any behavioral and clinical benefits that patients may derive from the use of such apps and how they may contribute to support improved patient experiences and treatment outcomes.
An Augmented Reality Mobile App (Easypod AR) as a Complementary Tool in the Nurse-Led Integrated Support of Patients Receiving Recombinant Human Growth Hormone: Usability and Validation Study (Preprint)
Authors: Baños Rosa Maria , Peltonen Laura-Maria , Martin Blaine , Koledova Ekaterina
Published: April 2023

BACKGROUND

Children with growth hormone deficiency face the prospect of long-term recombinant human growth hormone (r-hGH) treatment requiring daily injections. Adherence to treatment is important, especially at treatment initiation, to achieve positive health outcomes. Historically, telenursing services embedded in patient support programs (PSPs) have been a valid approach to support r-hGH treatment initiation and patient education and facilitate adherence by identifying and optimizing appropriate injection techniques. The development of mobile phones with augmented reality (AR) capabilities offers nurses new tools to support patient education.

OBJECTIVE

To investigate experiences among nurses of a new mobile phone app developed to support patient training with a phone-based PSP for r-hGH treatment.

METHODS

In 2020, the Easypod AR mobile app was launched to support nurse-driven telehealth education for patients initiating r-hGH therapy with the Easypod electromechanical auto-injector device. Nurses who were part of PSPs in countries where the Easypod AR app had been launched or where training was provided as part of an anticipated future launch of the app were invited to participate in an online survey based on the Mobile App Rating Scale to capture their feedback after using the app.

RESULTS

In total, 23 nurses completed the online questionnaire. They positively rated the quality of the app across multiple dimensions. The highest mean scores were 4.0 for engagement (ie, adaptation to the target group; SD 0.74), 4.1 (SD 0.79) for functionality (navigation) and 4.1 (SD 0.67) for aesthetics (graphics). Responses indicated the potential positive impact of such a tool on enhancing patient education, patient support, and communication between patients and PSP nurses. Some participants also suggested enhancements to the app, including gamification techniques that they felt have the potential to support the formation of positive treatment behaviors and habits.

CONCLUSIONS

This study highlights the potential for new digital health solutions to reinforce PSP nurse services, including patient education. Future studies could explore possible correlations between any behavioral and clinical benefits that patients may derive from the use of such apps and how they may contribute to support improved patient experiences and treatment outcomes.
Internet analytics of an innovative digital educational resource of Type 1 Diabetes HelloType1 in local languages for people living with diabetes families and healthcare professionals in Southeast Asia. (Preprint)
Authors: Ng Sze May , IV Malene , Nguyen Thy Khue , Le Khuong , Lim Yang Xian Lucas , Lek Ngee , Seal Samantha , Tange Steffen Yun , Zaini Azriyanti Anuar , Sahakitrungruang Taninee , Ficheroulle Anne Charlotte
Published: April 2023

BACKGROUND

There is minimal data of health outcomes for Type 1 Diabetes (T1D) in Southeast Asia (SEA) where government funding of insulin and blood glucose monitoring either do not exist or is limited. The full impact of Covid-19 pandemic on the national economies of SEA remain unknown. In the midst of the pandemic, in 2021 HelloType1 was developed by Action4Diabetes (A4D), a non-government organisation charity in collaboration with Southeast Asia local healthcare professionals as an innovative digital educational resource platform of T1D in local languages.

OBJECTIVE

The objectives of this study were to explore the usability and internet data analytics of the HelloType1 platform within each country.

METHODS

HelloType1 was launched in Cambodia, Vietnam, Thailand and Malaysia in 2021 to 2022 with Memorandums of Understanding (MOUs) signed between A4D and each country. Internet data analytics were undertaken between the 1st of January 2022 to 31st of December 2022.

RESULTS

There was a 147% increase in the number of HelloType1 users between the first 6 months versus the latter 6 months in 2022 and a 15% increase in the number of pages visited were noted. The majority of traffic source were coming from organic searches with a significant increase of 80% growth in 2022.

CONCLUSIONS

The results of the analytics provide important insights on how an innovative diabetes digital educational resource in local languages may be optimally delivered in low-middle income countries with limited resources.

CLINICALTRIAL

not applicable
Continued Use of Telehealth In Oncology Patients (Preprint)
Authors: Landau Daniel , Landau Alec
Published: April 2023

BACKGROUND

Prior to the Covid-19 pandemic, telehealth represented a small portion of our oncology practice. Despite offering telehealth availability, fewer than 10% of patients agreed to virtual visits. Administratively, there were concerns about patients’ ability to use the technology, a change in the traditional in office dynamic, questions about whether patients would consistently use these platforms, etc. At the height of the pandemic, as much as 30% of our practice became fully telehealth. As the height of the pandemic has waned, we continue to offer telehealth for both new and establishing patients. We opted to retrospectively look at the continued use of telehealth in our practice.

OBJECTIVE

Our objective was to determine if patients who did an initial telehealth visit would request future telehealth visits or if they would opt to return to the traditional in office model. Patients treated in 2022 were offered repeat telehealth visits or in person visits by the scheduling staff after their visit. The offer was presented without offering any bias toward future visit.

METHODS

25% of our practice has dedicated telehealth slots. Of patients who opted for a telehealth visit, we followed future visits to determine if they opted to continue use of telehealth technology. We also looked at the age of the patient and the diagnosis of the patient to look for trends.

RESULTS

With a retrospective review of 99 charts, we separated patients into new visits to the cancer center vs patients who were already established. Of the 23 new patient visits, 14 were for a new diagnosis of solid tumor oncology and nine had a hematologic diagnosis. The average age of these patients was 55 (32-80). 13/21 (62%) who had repeat visits did so virtually. Of 76 patients who were already established, 43 had a hematologic diagnosis, 33 a solid tumor diagnosis. The average age was 61 (21-88). 55/76 (72%) opted for repeat telehealth visits. No clear trends in terms of age or diagnosis emerged in terms of who accepted repeat telehealth visits.

CONCLUSIONS

For patients who had an initial telehealth visit, it was likely they would continue to use this technology. Concerns about the age of patient or type of diagnosis did not preclude continued use of telehealth. This supports the continued use of telehealth in the post pandemic setting.

CLINICALTRIAL

None
Diversity Among American Dermatological Association Members by Sex and Geographic Region (Preprint)
Authors: Rodriguez Ramiro , Anderson Lachlan , Woolhiser Emily , Balmorez Timothy , Cook Bailey , Hauptman Megan , Kirk Jessica , Keime Noah , Dellavalle Robert P
Published: April 2023

UNSTRUCTURED

N/A
Ischemia of lower limbs in the activity of a general practitioner — family physician: from widely spread to rare disorders (literature review with some results of the own clinical observations)
Authors: Rudichenko V.M. , Snigyr N.V.
Published: April 2023

The most common cause of ischemic disorders of the lower limbs is peripheral artery disease of atherosclerotic origin, the prevalence of which is constantly increasing. In Europe, ischemic heart disease is responsible for 20 % of men’s death and 22 % of women’s death, stroke is the cause of death in 10 % of men and 15 % of women. At the same time, other cardiovascular diseases, including peripheral artery disease, are the cause of 12 % of men’s death and 15 % of women’s death. Primary care physicians very often don’t have necessary awareness about diseases of peripheral arteries of the lower limbs in contrast to atherosclerotic lesions of coronary and cerebral vessels. Late diagnosis and lack of proper treatment result in severe complications, disability and death of such patients. The article contains literature data and current recommendations about diagnosis and treatment of the ischemic lesions of the lower limbs, namely intermittent claudication, chronic ischemia of the lower limbs with a risk of limb loss and acute ischemia of the lower limbs, which are necessary in the activity of a general practitioner — family physician. In the clinical practice, there are also cases of ischemic lesions of the limbs due to unusual and rare causes. The article contains literature data and own observations of such rare disorder, namely symmetrical peripheral gangrene.
Final observation of an extremely severe case of Osler-Weber-Rendu disease in teaching at the pregraduate and postgraduate stages of education and the use of current English-language Internet applications for doctors and patients
Authors: Rudichenko V.M. , Snigir N.V. , Кrivets V.О.
Published: April 2023

Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome, Osler-Weber-Rendu disease, etc) is diagnosed clinically according to the so called Curacao criteria, if at least three of four of them are present: recurrent spontaneous epistaxis, mucocutaneous telangiectasias on characteristic locations, visceral vascular lesions and same disease in close relative. The described clinical case with dramatic outcome demonstrates an extremely severe course of Osler-Weber-Rendu disease complicated with recurrent massive epistaxis, long severe posthemorrhagic anemia requiring systemic red blood cell transfusions all of which became unfavorable background for the development of a fatal coronavirus disease. Demonstrations to students and interns of a rare clinical case of hereditary hemorrhagic telangiectasia with the use of actual English-language Internet sites help to improve the process of teaching general practice — family medicine at the pregraduate and postgraduate levels.
Interactive Shopping Using Augmented Reality
Authors: Lokesh Pusuluru Sai , Sri Telu Ramya , Rao Thirupathi
Published: April 2023

Abstract: Interactive shopping using augmented reality (AR) is a rapidly growing field that provides consumers with a new and innovative way to shop. AR technology allows consumers to visualize products in their real-world environments, enhancing their shopping experience by providing a more immersive and interactive experience. This paper presents an overview of the current state of interactive shopping using AR and discusses the benefits and challenges of this emerging technology. The paper also explores the various applications of AR in shopping, including virtual try-on, product visualization, and interactive product demonstrations. Overall, the paper highlights the potential of interactive shopping using AR to revolutionize the retail industry and transform the way consumers shop.
Comparative Analysis of Composite Structure by STADD Pro Software
Authors: Prakash Divya , Singhai Dr. Praveen Kumar , Jha Abhay Kumar , Kumar Barun
Published: April 2023

Abstract: In comparison to many other emerging nations, India uses a fairly little amount of steel in the construction industry. Other nations' experiences suggest that this isn't because steel isn't economically viable as a building material. Maximum Axial Forces On Column Base Of The Structure Column RCC Structure (kN),steel Structure (kN) ,Difference in Foundation Size and Reinforcement Requirements Property RCC Structure, Steel Structure Size:- are found by staad pro software. .With the existing development requirements in India, there is a tremendous opportunity for raising the volume of steel in teaching. A significant loss for the nation results from not utilising steel where it is cost-effective as an alternative construction material. Also, it is clear that modern composite sections made of steel and concrete are a time, money, and cost-effective alternative for important civil structures like bridges and tall skyscrapers.
Malaria Cell Classification Using Transfer Learning
Authors: Deore Shreyas , Desai Pranav , Bhosale Ashish , Bhat Yeetish , Salian Prof. Saumya
Published: April 2023

Abstract: In recent years, machine learning techniques, particularly transfer learning, have shown promise in automating malaria cell classification using digital images of blood smears. Transfer learning involves leveraging pre-trained neural networks to extract relevant features from large datasets and applying them to smaller, specialized datasets for improved performance. This abstract provides an overview of the concept of malaria cell classification using transfer learning. It highlights the advantages of using transfer learning, including reduced training time and improved classification accuracy, while addressing challenges such as dataset bias and model interpretability. Further research and development in this area could potentially contribute to the automation and scalability of malaria diagnosis, particularly in resource-limited settings. This study describes a method for classifying malaria cells using convolutional neural networks. It has been evaluated using a standard dataset obtained from the National Library of Medicine, which consists of 27,000microscopic pictures. The accuracy of the neural network has been improved while the total loss has been reduced using the Adam optimizer. Overfitting has been avoided by using dropout regression
E2EE Web Messaging Application Using Cryptography Techniques
Authors: Bawake Harshvardhan , Cholke Saideep , Dhole Atharv , Jadhav Ankit , Bhise Prof. Aarti
Published: April 2023

Abstract: Instant messaging services on mobile devices, such as WhatsApp, have become immensely popular, largely due to their end-to-end encryption (E2EE) feature, which ensures user privacy. However, this has raised concerns for some governments who argue that E2EE makes it challenging to combat terrorism and organized crime. These governments have expressed the desire for a "backdoor" to access messages in cases of credible threats to national security. However, WhatsApp users have strongly opposed this idea, citing concerns about privacy infringement and potential exploitation by hackers. This paper presents the advantages of maintaining E2EE in WhatsApp and argues against granting governments a "backdoor" to access user messages. It highlights the benefits of encryption in safeguarding consumer security and privacy, while also acknowledging the challenges it poses to public safety and national security. In the realm of internet messaging security, cryptography plays a crucial role in protecting networks. This paper aims to raise awareness among common computer users about the importance of email security and its requirements. Several cryptographic techniques have been developed to achieve secure communication, and the proposed messaging system ensures security in accordance with standard security models.
Experimental Investigation on Surface Characteristics of Nickel-Based Super Alloy in Powder Mixed Electric Discharge Machining
Authors: A Anandan. , R Dr. Boopathi.
Published: April 2023

Abstract: Electrical discharge machining behavior of nickel based super alloy using titanium carbide powder mixed dielectric fluid turned into studied. Experiments were completed consistent with face centered central composite design. The addition of powder particles in suspension in the dielectric modifies some process variables and creates hard and brittle materials with nano surface finish, high tolerance and accuracy to achieve a material removal rate increase. The effect of input parameters such as current, pulse on-time and flushing pressure on the output responses like material removal rate and tool wear rate are evaluated. Dielectric fluid used in this experiment was kerosene mixed with titanium carbide powder.
Multi-Purpose CNC Ink Plotter using Arduino
Authors: Gojare Ajay , Malekar Jatin , Prasad Ravikumar , Tamore Nachiket , Thakur Harsh
Published: April 2023

Abstract: The use of CNC equipment in industry is increasing with the rapid development of technology. For lowering the machine complexity and expense the production of inexpensive CNC machine is used. This paper describes an automated micro CNC devices design for drawing printed circuit boards. The basic idea of this paper is to design low cost PCB based CNC hardware and by integrating PC functionality with an ATMEGA328 controller into an Arduino the startup cost was achieved. For completion of machine operation we used G-code. G-code is nothing but a language use to command machine “how to do something”. How is that determined by the guidelines on how to transport and how to move fast. computer numerical control, Arduino microcontroller, part program, interpolator. In this project, we are creating a low-cost, easy-to-use, and easy-to-move CNC-based ink plotter. The CNC-based ink plotter is required to plot the diagram and sketch it on paper, but the main requirement is to design the PCB.
Overseas Research Trends Related to Peer Supervision
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Mun Young-Joo , Kang Hye-Young
Published: April 2023

Objectives The purpose of this study is to identify the current status of peer supervision research by looking at overseas research trends related to peer supervision, and to seek implications for the vitalization of peer supervision research in Korea.
Methods As a result of cross-searching for terms related to ‘peer supervision’ in academic databases and reviewing them three times, the final 160 articles were selected for study analysis. In this study, research trends were analyzed in four aspects: by year, by research method (quantitative, qualitative, mixed, literature), by operation (number of people, time), and research scene (education, health care, social welfare).
Results First, when looking at each year, it was found that more than one study was conducted every year, except for some specific years from 1962 to 2021. When looking at the 10-year cycle, the rate of research in the 2010s was the highest (32.5%). Second, by research method, qualitative research conducted the most (41.9%), followed by literature research (28.1%), quantitative research (18.7%), and mixed research (11.3%). Third, by operation, studies targeting 3 to 9 people were the most common (37.4%), and studies that lasted more than 50 minutes to less than 90 minutes were found to be the most common (53.0%). Fourth, in the research scene, studies in the education field were found to be the most(38.1%), except for ‘Other’, where it is difficult to distinguish a specific field, and research in the health care and social welfare fields was also confirmed.
Conclusions Overseas research on peer supervision is not being actively conducted even though it has been going steadily from the early 1960s to the present of 2021. The proportion of qualitative research was higher than quantitative research, and the study subjects consisted mainly of a small number of 10 or less. In the research scene, the educational field of elementary and secondary schools and universities was centered, and research was also conducted in various fields such as health medical, and social welfare.
Self-Narrative Inquiry of Teachers’ Experiences on Coeducational Physical Education Class Practice in Middle School
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park SungKi , Lee Ansu
Published: April 2023

Objectives The purpose of this study was to explore teachers’ experiences on coeducational physical education class practice in middle school.
Methods Focusing on the researcher's own story as a research participant was conducted for 10 months from March 2021 to December 2021 using the self-narrative inquiry.
Results The researcher talked about the experiences of classes from the first experience of physical education class in a mixed gender class to volleyball and cheerleading as a method of learning by each other, for each other, and together. Through this, three educational meanings were derived. First, the mixed-gender class physical education class served as an opportunity to cultivate the values of respect and consideration for students. Second, through the mixed-gender class physical education class, it was found that the teacher's change in perception for the mixed-gender class physical education class was an important factor. Third, through the mixed-gender class physical education class, it became an experience to reexamine the value of the mixed-gender class physical education class.
Conclusions It is hoped that the results of this study will help improve practical knowledge and class expertise for physical education teachers who are thinking about and practicing efficient coeducational physical education classes.
Interpretative Phenomenological Analysis of Career Guidance Education Experience for Senior High School Homeroom Teachers: Based on the COVID-19 situation
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Byun You Kyoung , Park kyung A
Published: April 2023

Objectives This study is an interpretative phenomenological study of the experience of high school homeroom teachers' career guidance education in the context of COVID-19. In this study, the difficulties and overcoming strategies of high school homeroom teachers' career guidance were analyzed in the context of the COVID-19 pandemic.
Methods For this purpose, among the qualitative research methods, an interpretative phenomenological analysis suggested by Smith et al. (2009) was approached. Interpretive phenomenological analysis is a research approach that goes beyond the phenomenological research practice of describing the experiences of research participants and allows researchers to understand participants' experiences more deeply and form a consensus through active interpretation. The data analysis was analyzed by the six-step procedure presented by Smith et al. (2009). The data was constructed by conducting one-on-one in-depth interviews with research participants.
Results The results of the study were derived from 23 sub-themes and 7 upper themes. The 7 upper themes are: Crisis in the formation of rapport between students and teachers; burden of responsibility for quarantine other than education and class operation; cultivation of independent educational capabilities even in crisis; Establishing a regular communication channel with students, strengthening crisis management resources through information sharing and mutual communication, and a sense of calling as teachers appeared to be the sources of escape from the crisis.
Conclusions Based on the results of this study, we discussed the crisis response leadership of high school senior homeroom teachers, the formation of a cooperative system with parents for school crisis management resources, and ways to promote information sharing and communication among teachers, and suggested the creation of a school that is resistant to crisis.
A Study on exploring the alternative paradigm of career education in middle school based on main thoughts advocated by Ivan Illich
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim MinChae , Kim YoungHwan
Published: April 2023

Objectives Based on Ivan Illich's key ideas, this study explored an alternative paradigm for secondary career education.
Methods The research method involved an inductive content analysis of four of Illich's works that cover education and labor.
Results First, Illich's key ideas were divided into two main areas: insight and alternatives. The insight area comprised three factors (1. radical monopoly, 2. the decline of vernacular and commons, and 3. the birth of modern slavery) that reveal the hidden nature and violence of modern civilization. The alternative area consisted of institutional and cultural alternatives, with convivial retooling as the institutional factor and the recovery of the autonomous and creative life as the cultural factor. Second, an alternative paradigm for secondary career education in Korea based on Illich's key ideas emerged as a “journey toward autonomous and convivial life based on the local community” represented by a “horizontal and non-linear spider web” model.
Conclusions To transition to an alternative paradigm based on Illich's key ideas, changes are required in the perception, system, and cultural dimensions of existing career education. First, in terms of perception, “career” needs to be understood as “a process of contemplating what is the best life for oneself,” and “career education” needs to be recognized as “providing an educational environment and support system to develop the capabilities and confidence needed for such a life.” Second, a new form of the career education system needs to be established, moving away from the entrenched existing educational system. Finally, in the cultural dimension, society needs to reflect on and transform the current career education system. Additionally, future research should examine a more diverse range of alternative cases, such as SOLE, Gaviotas, and Cuba's educational revolution, that has been overlooked by our education system due to social ideologies and other reasons.
Mediating Effects of College Students’ Autonomous Motivation and Self-Efficacy in the Relations between Perceived Supportive Teaching-Learning Environment and Core Competencies
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Duck Hee , Shin Hyeonsook
Published: April 2023

Objectives The purpose of this study was to test the structural relations among the factors that influence college students’ core competencies such as problem-solving competency and self-directed learning competency. Specifically, supportive teaching-learning environment was composed of faculty-student interaction, effective instructional practices, peer relations, staff-student relations, and on-campus support services. This study was conducted to test mediating effects of college students’ autonomous motivation and self-efficacy in the relations between each of the perceived supportive teaching-learning environment factors and core competencies.
Methods Five-hundred eight students who were attending C University in G City participated in this study. Data analyses were conducted through the structural equation modeling and bootstrapping procedure using SPSS 25.0 and Amos 25.
Results The direct effects of the perceived supportive teaching-learning environment on core competencies were not significant. However, some of the perceived supportive teaching-learning environment factors influenced college students’ core competencies through the mediation of autonomous motivation or self-efficacy or both. The mediating effects of autonomous motivation were found to be significant in the relations of faculty-student interaction, staff-student relations, and on-campus support services to core competencies. The mediating effect of self-efficacy was found to be significant only in the relation of peer relations to core competencies. Also, the serial mediating effects of autonomous motivation and self-efficacy were significant in the relations of faculty- student interaction, staff-student relations, and on-campus support services to core competencies.
Conclusions The results of this study have significance in that the perceived supportive teaching-learning environment may not directly influence college students’ core competencies but may indirectly influence core competencies through the mediation of autonomous motivation and self-efficacy. Efforts have to be made not only to improve supportive teaching-learning environment but also to enhance college students’ autonomous motivation and self-efficacy.ect
Analysis of Factors Causing Anxiety in Children with Cancer Experiencing Hospitalization
Authors: Hasnani Fenti
Published: April 2023

Hospitalization is a stressful experience, both for the child and his parents. Stress in children can cause sleep disturbances, decreased appetite, and developmental disorders so that this can delay the healing process of the disease. Stressors that children receive while being treated can be in the form of a foreign hospital environment, physical conditions such as pain and illness that children experience, treatment procedures and medical examinations at the hospital. The many stressors experienced by children while undergoing hospitalization have negative impacts that interfere with children's development. The purpose of this study was to determine the dominant of the six factors that cause anxiety in children with cancer who experience hospitalization. This study used an analytic descriptive design with a cross sectional study approach. Samples that met the inclusion criteria amounted to 165 people. The results of the six factors that cause anxiety in children with cancer who experience hospitalization, it was found that those with a p value <0.05 were complaints of pain and physical weakness. In complaints of pain, 163 children with cancer were found with an average anxiety score of 21.34. The statistical test produces a p value of 0.001 which is smaller than α (0.05), meaning that there is a significant relationship between pain and anxiety in children with cancer.

Keywords: Anxiety, childhood cancer, hospitalization
A Detail Insight of Wilson’s Disease and its Treatment
Authors: Patel Payal Vinod , Reddy Aishwarya , Wankhade Pavankumar Pandurang
Published: April 2023

Wilson disease is a rare inherited autosomal recessive genetic disorder caused by abnormal copper accumulation in the body, particularly involving the brain, liver, eyes, and other vital organs. This is also known as hepatolenticular degeneration. It primarily affects the liver and basal ganglia of the brain, but it can affect other vital organs too. It results from a mutation in the gene encoding the Wilson disease protein (ATP7B). It results from a mutation in the gene encoding the Wilson disease protein (ATP7B). A healthy body excretes extra copper through urine after the liver filters it out. Wilson's disease prevents the liver from effectively removing the excess copper. The extra copper then builds up in organs such as the brain, liver, and eyes; which is the reason why symptoms are usually related to the brain and liver. One of the 23 chromosomes in humans, chromosome 13, has a gene that causes Wilson's disease. For six months, a 12-year-old kid with Wilson's disease complained of speech problems, swallowing issues, and general stiffness. About 97 percent of those with Wilson's illness have K-F rings. Vomiting, weakness, ascites, yellowing of the skin, and brain or neurological symptoms like tremors, muscle stiffness, difficulty speaking, personality changes, or visual hallucinations are only a few of the symptoms associated with the liver. Sunflower cataracts are visible in 1 in 5 patients with Wilson's illness. One in 90 people in the general population are carriers of Wilson's illness. A liver biopsy, clinical evaluation, blood testing, urine tests, and a challenging diagnosis are all required. The family members of persons with the condition may be screened via genetic testing. For Wilson's disease to be stopped in its tracks, early detection is essential. Treatment can be done by both ayurvedic remedies using herbs and allopathy using drugs with specific target sites important for managing Wilson disease. WD can be treated with Copper chelating agents and Herbs act as a supporting treatment. Some drugs are still in the clinical trial phase.

Keywords: Kayser-Fleischer rings, Wilson disease (WD), ALXN1840, d-Penicillinase, Vatavyadhi.
Career Development and Psychopathological Symptoms on Female Workers
Authors: Merijanti Lie Tanu , Pusparini Pusparini , Meiyanti Meiyanti , Alvina Alvina , Hartanti Monica Dwi , Tjahjadi Muljadi
Published: April 2023

Women workers face a variety of challenges in the world of work.  In addition to facing dual role conflicts for married female workers, they also face various stressors at their jobs. This will leave women vulnerable and have an impact on workers' emotional well-being. This study sought to ascertain the connection between female workers' propensity for psychopathological symptoms and occupational stressors. One hundred and thirty-four female office workers were recruited for this cross-sectional study. Subjects were questioned about age, education, marital status, and years of work for describing respondents’ characteristics. The diagnostic stress survey and symptom checklist 90 were used for measuring work stressors and determining the tendency of psychopathological symptoms, respectively.  Data were statistically analyzed using the chi-square test,  the Fisher exact test, and logistic regression, where appropriate, with a meaningfulness level of p < 0,05.    Results show that quantitative workload stressors,  qualitative workloads, and career development are associated with psychopathological symptoms, but after continuing with  The Logistic regression test found that career development stressors were mainly associated with the appearance of psychopathological symptoms ( p= 0.003; OR= 10,069.95 % CI 2,238 – 45,296).  Female workers who experience barriers to career development have a 10-fold risk for the occurrence of psychopathological symptoms.

Keywords:  Female Worker,  work stressor, a psychopathological tendency
Pharmaceutical Cocrystals: An Emerging Approach to Modulate Physicochemical Properties of Active Pharmaceutical Ingredients
Authors: Tupe Suraj Ankush , Khandagale Shital Prabhakar , Jadhav Amrapali B.
Published: April 2023

Most of the Active Pharmaceutical Ingredients (APIs) are typically formulated and administered to patients in oral solid dosage forms due to ease of administration, patient compliance and cost effectiveness. Poor water solubility, low permeability and low bioavailability of APIs are major hurdles in development of oral solid dosage forms. In recent years, cocrystal development has evolved as a feasible approach for enhancing the solubility and bioavailability of poorly soluble drugs. Crystal engineering strategies have been asserted to enhance the likelihood of discovering new solid forms of an API. A pharmaceutical cocrystal is made up of two basic components, an API and a harmless material known as a coformer in stoichiometric ratio. Cocrystallization of an API with a pharmaceutically acceptable coformer can improve the physical characteristics of the API, such as solubility, hygroscopicity, and compaction behavior, without affecting the API's pharmacological efficacy. This review article offers a comprehensive overview of pharmaceutical cocrystals, their physiochemical characteristics, and methods of preparation, with an emphasis on cocrystal screening and cocrystal characterization. The review also included recent FDA and EMA guidance on pharmaceutical cocrystals as well as an outline of multidrug cocrystals.

Keywords: Pharmaceutical co-crystals, crystal engineering, coformers, supramolecular synthons, Solubility
Non-Selective Beta-Adrenergic Blocker Propranolol: A Life Saving Drug for Hospitalized Patient with Traumatic Brain Injury in Intensive Care Unit
Authors: Ashwathi P , Srinivas K
Published: April 2023

Background: Traumatic Brain Injury (TBI) is the most common cause of death under the age of forty. This in turn results in intracranial injury in about 90% of the cases from least-income countries. The majority of patients admitted to the Intensive care Unit (ICU) had trauma which is managed by preventive strategies and to combat the secondary hit stimulated by the primary hit International guidelines have formed a protocol to be applied in patients with TBI for the better outcome and to increase the survival rate.

Objectives: The aim of this study was to determine the importance of beta-adrenergic blocker propranolol in patients admitted with TBI.

Methodology: The literature search was conducted to find recent articles related to the aim of the study to analyze the significance of beta-blocking agent propranolol in TBI.

Results: Paroxysmal Sympathetic Hyperactivity (PSH) occurs within 24 hours of TBI in patients with Glasgow Coma Scale (GCS ≤ 8). In patients who are agitated or in restlessness propranolol is the drug of choice to reduce hyperactivity. Several studies reported that using beta-adrenergic blocking agents decreases the mortality rate and current studies started focusing on the primary initiation of propranolol and also reported side-effects associated in TBI.

Conclusion: Early administration of Non-selective beta-adrenergic blocker propranolol will continue to be the standard prophylactic pharmacotherapeutic method as it limits the risk of sympathetic storming in high-risk patients with TBI.

Keywords: Traumatic Brain Injury (TBI), Propranolol, Beta-adrenergic blocker, Paroxysmal Sympathetic Hyperactivity (PSH).
Seroprevalence of Hepatitis B, Anti-Hepatitis C, Human Immunodeficiency Viruses and Treponema Pallidum among Random Blood Donors at Somali Sudanese Specialized Hospital (SSSH), Mogadishu, Somalia
Authors: Hamad Mohamed Motaz Obeidallah , Osman Ebar Mohamed Hassan
Published: April 2023

Background: Blood transfusion is one of essential and important components in Human health care system. Blood transfusion at sometimes poses the risk of transfusion transmitted infections; HBV, HCV, HIV and Syphilis infections. The aim of this study was to determine the seroprevalence of HBV, anti-HCV, HIV and syphilis in random blood donors.

Materials and methods: The study was descriptive cross-sectional hospital-based study conducted at Somali Sudanese Specialized Hospital, Mogadishu, Somalia, during the period from December 2022 to March 2023. Blood samples were collected from 420 random blood donors. A total of five ml of whole blood was collected from each participant and divided into EDTA ant coagulated containers for hemoglobin estimation    and     into     sterile plain containers   for   HBV, anti-HCV, HIV and syphilis screening. Estimation of hemoglobin concentration was done by using Hematology analyzer (URIT 5380), where HBV, anti-HCV, HIV, and Syphilis screening was done by using Immunochromatographic test (ICT).

Results: The results of this study revealed that the prevalence of HBV and Syphilis in the donors was 2.1% and 0.7% respectively, where the prevalence of HIV and HCV was 0%. The distribution of blood groups was 4.0%, 12.4%, and 26.9%, 0.5%, 51.4% and 4.8% (AB+ve, B+ve, A+ve, A-ve, O+ve, and O-ve) respectively, this showed that the most frequent Blood group was O positive followed by A positive.

Conclusion: This study concluded that the prevalence of HBV and syphilis was high in blood donors, where HIV and anti-HCV had low prevalence rate in the study population.

Keywords: HBV, HCV, HIV, syphilis, blood bank, blood transfusion, viral screening
Changes in nutrient and heavy metal content after vermicomposting of water hyacinth-based spent mushroom substrate
Authors: Mukhopadhyay Sunita Bandopadhyay
Published: April 2023

The spent biomass of water hyacinth (Eichhornia crassipes) after oyster mushroom cultivation is not much suitable for application as soil amendment. As a means to avoid environmental pollution and to decrease waste to landfill, the spent biomass was primarily composted with cow dung and then feed to red wiggler earthworm (Eisenia fetida) to transform it into vermicompost. The produced vermicompost showed significant reduction in salt concentration, electrical conductivity, available K concentration, C/N ratio and increase in pH, available N and P. The representative heavy metals (Fe, Cu, Zn, Pb and Cd) detected in the spent biomass of water hyacinth were derived from the initial plant biomass. Among these metals, concentration of Fe increased and that of Zn decreased significantly in the vermicompost, while the other metals did not show significant change. When applied as amendment to control soil for growth of radish plants, the vermicompost treatment resulted in significantly higher shoot and root biomass. Also, the amendment decreased the bioavailability of metals (especially Cd) and their accumulation in radish plants. The metal concentrations in the vermicompost and in the radish plants were found to fall within the permissible limits for compost and the normal range present in plants, respectively, indicating the suitability of the vermicompost for use as organic fertilizer. Utilization of the water hyacinth as substrate for oyster mushroom cultivation and recycling the spent mushroom substrate through vermicomposting could therefore provide food and fertilizer with no waste to landfill, changing the status of the invasive aquatic weed from a prolific pest to a potentially usable product.
Modeling 3D-changes in the terrain relief due to slope erosion
Authors: Lurie I.K. , Lurie M.V.
Published: April 2023

The authors propose an algorithm for predictive monitoring of 3D-changes in the terrain relief due to the processes of slope erosion. The algorithm is based on the phenomenological law, from which it follows that the intensity of soil losses at the slope is proportional in magnitude and inverse in the direction of the declivity height gradient vector. In conjunction with the differential equation of mass balance, a mathematical model of the terrain relief change is built. The model enables calculating it at an arbitrary time according to its shape at the initial moment based on the solution of a standard mathematic boundary task. Comparing the results of solving such a problem with the data of cartographic monitoring makes it possible to establish a relationship between the slope erosion coefficient and the type of soil, vegetation cover, and meteorological conditions under which the studied area is located, and then predict changes in the terrain relief in the future.
The Role of China’s “Five Principles of Peaceful Coexistence” in Establishing a Multipolar World Order
Authors: Nechai A. A.
Published: April 2023

In the 21st century, with the emergence on the world stage of a new strong actor in international relations — the People’s Republic of China — it became obvious that the Western model of global governance must be revised or at least an alternative must be proposed to it. China has consistently advocated the formati on of a multipolar world order built on the principles of pluralism of interests and civilizational diversity, which are reflected in the concept of the Five Principles of Peaceful Coexistence. The idea of peaceful coexistence is more relevant than ever.

Aim. The purpose of this study is to determine the use of the Five Principles of Peaceful Coexistence in China’s foreign policy strategy.

Tasks. Analyze the content of the “Five Principles of Peaceful Coexistence” and trace their reflection in the PRC’s foreign policy activities by the example of the state’s actions in relation to conducting a Special military operation.

Methods. During the study, the author used the method of historical retrospective, as we ll as the method of analyzing documents.

Results. The relevance of the application of the concept of “Five Principles of Peaceful Coexistence” in the foreign policy of China was substantiated; each principle was characterized, the peculiarities of their application in relation to the conduct of Special military operation were revealed.

Conclusions. The origins of the Five Principles of Peaceful Coexistence can be seen in Confucianism, which implies harmony without unification. In the 21st century, China is actively taking initiatives to form a new world order, taking the “Five Principles of Peaceful Coexistence” as a basis, working to create a positive image of the country. The principles of peaceful coexistence are reflected in the state’s position on the special military operation in Ukraine: China calls to respect national sovereignty, observing the principles of the UN Charter, supports a peaceful dialogue between the two countries, which will take into account the interests of both sides, and follows the principle of non-interference in the internal affairs of Russia, abstaining from voting in the UN Security Council on the Ukrainian issue, condemns sanctions as an unacceptable instrument of influence in world politics. PRC officials are convinced that the conflict was provoked by NATO’s eastward expansion and that it is part of Russia’s defense policy, as NATO expansion poses a direct threat to Russian national security. Defending peace and opposing armed clashes is a historical and cultural tradition China has maintained during the conflict.