bluuebunny/crossref_metadata_2025 huggingface dataset:
Central Asia on the way of One Belt, One Road – implications for the European Union
Authors: Fiedler Radosław
Published: February 2019

Inicjatywa Pasa i Szlaku stwarza możliwości jak i wyzwania dla regionu Azji Centralnej. Inwestycje infrastrukturalne wraz z rozwijającymi się połączeniami kolejowymi przybliżają ten region do Europy. Chińska inicjatywa wiąże się z koncepcją budowania strefy wpływów w regionie Azji Centralnej i stopniowego wypierania innych partnerów w tym państw Unii Europejskiej. W przygotowywanej nowej strategii UE wobec Azji Centralnej należy uwzględnić znaczenie Nowego Jedwabnego Szlaku z jego pozytywnymi jak i negatywnymi uwarunkowaniami.
Cooperation at the Institutional and Bilateral Level of the European Union and Central Asia
Authors: Pazdej Mateusz
Published: February 2019

W niniejszym artykule analizie poddano zakres współpracy na poziomie instytucjonalnym i bilateralnym Unii Europejskiej i Azji Centralnej. Mimo systematycznego zacieśniania współpracy Brukseli z republikami byłego ZSRR, nadal brakuje jednoznacznego określenia rzeczywistych, długookresowych interesów Unii Europejskiej w regionie. Zasadniczym problemem rozwoju współpracy jest silne rozdrobnienie działań unijnych w pięciu różnych republikach Azji Centralnej. W związku z tym wskazuje się konieczność poprawy wymiany informacji, zwiększenia kontroli i koordynacji, a także ograniczenia zakresu tematycznego podejmowa­nych inicjatyw. Istnieją potencjalne możliwości dywersyfikacji źródeł surowców energetycz­nych, które występują w regionie Azji Centralnej.
Rada Europejska w procesie przekształceń strukturalnych 1961-1977
Authors: Przybylska-Maszner Beata
Published: February 2019

Rada Europejska stopniowo przekształciła się w ośrodek podejmowania decyzji politycznych EWG, później Unii Europejskiej. Jej zakres formalnych i nieformalnych uprawnień stale się zwiększał. Kolejne postanowienia polityczne i wprowadzane prawne regulacje wyznaczały znaczące etapy tego procesu, ponieważ określały jej rolę i wiodącą funkcję w EWG. Artykuł odnosi się do źródeł i przejawów dynamiki instytucjonalnej w procesie rozwoju Rady Europejskiej w okresie 1961-1977. Jego celem jest analiza czynników warunkujących powstanie i rozwój Rady Europejskiej w świetle przyjmowanych decyzji politycznych, a także praktyki jej działań. Przedstawione w artykule zagadnienie oparte zostało na założeniu, iż ład strukturalny cechuje znacząca asymetryczność. Narastanie współzależności w kształtowanych relacjach między państwami w sytuacji potrzeby i konieczności współpracy zbiega się z procesem zmian w odniesieniu do konieczności kształtowania nowych funkcji instytucji. To znacząco wpłynęło na dynamikę międzyinstytucjonalnych przekształceń. Określając determinanty wpływające na te przekształcenia podkreślić należy funkcjonalność systemu, a także jego ograniczenia.
Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain
Authors: Safary Azam , Moniri Rezvan , Hamzeh-Mivehroud Maryam , Dastmalchi Siavoush
Published: February 2019

Introduction: The bacterial enzyme has gained more attention in therapeutic application because of the higher substrate specificity and longer half-life. L-asparaginase is an important enzyme with known antineoplastic effect against acute lymphoblastic leukemia (ALL). Methods: Novel L-asparaginase genes were identified from a locally isolated halo-thermotolerant Bacillus strain and the recombinant enzymes were overexpressed in modified E. coli strains, OrigamiTM B and BL21. In addition, the biochemical properties of the purified enzymes were characterized, and the enzyme activity was evaluated at different temperatures, pH, and substrate concentrations. Results: The concentration of pure soluble enzyme obtained from Origami strain was ~30 mg/L of bacterial culture, which indicates the significant improvement compared to L-asparaginase produced by E. coli BL21 strain. The catalytic activity assay on the identified L-asparaginases (ansA1 and ansA3 genes) from Bacillus sp. SL-1 demonstrated that only ansA1 gene codes an active and stable homologue (ASPase A1) with high substrate affinity toward L-asparagine. The Kcat and Km values for the purified ASPase A1 enzyme were 23.96s-1 and 10.66 µM, respectively. In addition, the recombinant ASPase A1 enzyme from Bacillus sp. SL-1 possessed higher specificity to L-asparagine than L-glutamine. The ASPase A1 enzyme was highly thermostable and resistant to the wide range of pH 4.5–10. Conclusion: The biochemical properties of the novel ASPase A1 derived from Bacillus sp. SL-l indicated a great potential for the identified enzyme in pharmaceutical and industrial applications.
In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens
Authors: Parvizpour Sepideh , Razmara Jafar , Pourseif Mohammad M. , Omidi Yadollah
Published: February 2019

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CTA)-positive tumor, indicating that the CTA-based cancer vaccine can be a treatment option for the patients bearing such tumors. Of these antigens (Ags), the MAGE-A family and NY-ESO-1 as the most immunogenic CTAs are the potentially relevant targets for the development of an immunotherapeutic way of the breast cancer treatment. Methods: In the present study, immunoinformatics approach was used to design a multi-epitope peptide vaccine to combat the TNBC. The vaccine peptide was constructed by the fusion of three crucial components, including the CD8+ cytotoxic T lymphocytes (CTLs) epitopes, helper epitopes and adjuvant. The epitopes were predicted from the MAGE-A and NY-ESO-1 Ags. In addition, the granulocyte-macrophage-colony-stimulating factor (GM-CSF) was used as an adjuvant to promote the CD4+ T cells towards the T-helper for more strong induction of CTL responses. The components were conjugated by proper linkers. Results: The vaccine peptide was examined for different physiochemical characteristics to confirm the safety and immunogenic behavior. Furthermore, the 3D-structure of the vaccine peptide was predicted based on the homology modeling approach using the MODELLER v9.17 program. The vaccine structure was also subjected to the molecular dynamics simulation study for structure refinement. The results verified the immunogenicity and safety profile of the constructed vaccine as well as its capability for stimulating both the cellular and humoral immune responses. Conclusion: Based on our in-silico analyses, the proposed vaccine may be considered for the immunotherapy of TNBC.
On the Path to UHC – Global Evidence Must Go Local to Be Useful Comment on "Disease Control Priorities Third Edition Is Published: A Theory of Change Is Needed for Translating Evidence to Health Policy"
Authors: Davis Austen , Walker Damian G.
Published: February 2019

The Disease Control Priorities (DCP) publications have pioneered new ways of thinking about investing in health. We agree with Norheim, that a useful first step to advance efforts to translate DCP’s global evidence into local health priorities, is to develop a clear Theory of Change (ToC). However, a ToC that aims to define how global evidence (DCP and others) can be used to inform national policy is too narrow an undertaking. We propose efforts should be directed towards developing a ToC to define how to support progressive institutional development to deliver on universal health coverage (UHC), putting the client at the center. Enhancing efforts to meet the new global health imperatives requires a shift in focus of attention to move radically from global to local. In order to achieve this we need to reorganize the nature of technical assistance (TA) along three major lines (1) examine and act to clarify the mandates and roles to be played by multilateral normative and convening agencies, (2) ensure detailed understanding of local institutions, their needs and their demands, and (3) provide TA over time and in trust with local counterparts. This last requirement implies the need for long-term local presence as well as an international network of expertise centers, to share scarce technical capabilities as well as to learn together across country engagements. Financing will need to be reorganized to incentivize and support demand-led capacity strengthening.
The Future of Disease Control Priorities Comment on "Disease Control Priorities Third Edition Is Published: A Theory of Change Is Needed for Translating Evidence to Health Policy"
Authors: Jha Prabhat
Published: February 2019

The Disease Control Priorities (DCP) project has substantially influenced national and global health priorities since 1993. DCP’s basic framework involves identification of disease burdens based on premature deaths and disability and application of the most cost-effective interventions to the largest burdens, taking into account local feasibility. The future impact of DCP will need to take into account growing national wealth and needs for endogenous capacity to design and implement evidence-based interventions, the rapid emergence of non-communicable disease (NCD), and the universal health coverage (UHC) agenda. This in turn requires three improvements to the DCP framework: greater local capacity, supported by a global effort to cost health interventions, stronger national and international technical capacity and networks, and the use of direct, versus modelled, mortality data to assign priorities and to assess progress. Properly done, DCP could be as important over the next 25 years as it has been in the past 25 years.
Leadership for Innovation in Healthcare: An Exploration
Authors: Weintraub Philip , McKee Martin
Published: February 2019

Although leadership has been studied extensively, most research has focused on the political and military spheres. More recent work has also examined the role of leadership in sectors such as manufacturing and technology, both areas where it is essential to encourage and nurture innovation. Yet, in the health sector, where innovation is now high on the policy agenda in many countries, there is a paucity of research on how leadership can foster a culture of innovation. In this perspective, written for those seeking to foster innovation in the health sector, we offer a narrative synthesis approach of eight theories and concepts that have been empirically shown to support innovation through all phases of the innovation process.
Searching for the territorial origins of England
Authors: Brookes Stuart
Published: February 2019

When the Normans arrived in England in AD 1066 they found a kingdom divided into a distinctive and complicated administrative geography. In compiling Domesday Book, the great survey of holdings and liabilities over much of England and parts of Wales completed in 1086, the assessors grouped information firstly into ‘shires’—districts that are in many cases the precursors of modern counties—and then into smaller divisions such as hundreds, wapentakes and vills (estates), with additional groupings such as multiple hundreds and regional ealdormanries also discernible in the source. These administrative entities clearly had a territorial composition. Using the boundaries of estates, parishes and hundreds mapped at later dates, numerous scholars have sought to reconstruct the administrative geography described in Domesday Book. The resulting maps have, in turn, been interpreted as the product of several centuries of developing territoriality and of continual social and political change. The shires of Norfolk and Suffolk (the ‘north’ and ‘south folk’), for example, appear to fossilise the extents of the kingdom of the East Anglians as it existed 300 or 400 years before Domesday survey; in other cases, clusters of hundreds have been argued to represent post-Roman tribal groupings.
The early settlement of Northern Europe
Authors: Robson Harry K.
Published: February 2019

This three-volume publication presents an up-to-date overview on the human colonisation of Northern Europe across the Pleistocene–Holocene transition in Scandinavia, the Eastern Baltic and Great Britain. Volume 1, Ecology of early settlement in Northern Europe, is a collection of 17 articles focusing on subsistence strategies and technologies, ecology and resource availability and demography in relation to different ecological niches. It is structured according to three geographic regions, the Skagerrak-Kattegat, the Baltic Region and the North Sea/Norwegian Sea, while its temporal focus is Late Glacial and Postglacial archaeology, c. 11000–5000 cal BC. These regions are particularly interesting given the long research history, which goes back as far as the nineteenth century (see Gron & Rowley-Conwy 2018), and the numerous environmental changes that have taken place throughout the Holocene: the presence of ice until c. 7500 cal BC, isostatic rebound alongside sea-level rise and the formation of the Baltic Sea, all of which have contributed to the preservation of outstanding archaeology.
Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction
Authors: Shu Tingting , Lv Zhigang , Xie Yuchun , Tang Junming , Mao Xuhua
Published: February 2019

It has been well established that glucotoxicity induces pancreatic β-cells dysfunction; however, the precise mechanism remains unclear. Our previous studies demonstrated that high glucose concentrations are associated with decreased hepcidin expression, which inhibits insulin synthesis. In this study, we focused on the role of low hepcidin level-induced increased iron deposition in β-cells and the relationship between abnormal iron metabolism and β-cell dysfunction. Decreased hepcidin expression increased iron absorption by upregulating transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) expression, resulting in iron accumulation within cells. Prussia blue stain and calcein-AM assays revealed greater iron accumulation in the cytoplasm of pancreatic tissue isolated from db/db mice, cultured islets and Min6 cells in response to high glucose stimulation. Increased cytosolic iron deposition was associated with greater Fe2+ influx into the mitochondria, which depolarized the mitochondria membrane potential, inhibited ATP synthesis, generated excessive ROS and induced oxidative stress. The toxic effect of excessive iron on mitochondrial function eventually resulted in impaired insulin secretion. The restricted iron content in db/db mice via reduced iron intake or accelerated iron clearance improved blood glucose levels with decreased fasting blood glucose (FBG), fasting blood insulin (FIns), HbA1c level, as well as improved intraperitoneal glucose tolerance test (IPGTT) results. Thus, our study may reveal the mechanism involved in the role of hepcidin in the glucotoxcity impaired pancreatic β cell function pathway.
Estrategias argumentativas utilizadas por los estudiantes de la institución educativa Divino Niño de Tierra Grata (Chinú) en el análisis de hechos históricos culturales
Authors: Muñoz Arévalo Neila
Published: February 2019

In the teaching of science, the development of argumentation should be privileged, in favor of the construction and understanding of knowledge in the classroom. The present study is a contribution to their development and to the didactics of science teaching through the analysis of classroom discourse in secondary school students. In this, we reflect on the incidence of argumentative strategies and the quality of the arguments in the conceptual evolution of historical cultural events (Identity, History and Culture), assessing the quality model of the arguments of Sampson and Clark (2009) and their relationship with the argumentative model of Candela (2006) analyzing its implications in the definition of contents that oscillate between common knowledge and scientific knowledge.
Prácticas contables y tributarias que adoptan los pequeños negocios en Colombia
Authors: Flórez Guzmán Mario Heimer , Cabrera Jaramillo Ruby Stella , Londoño Toro Carlos Mario
Published: February 2019

This paper aims to describe accounting and tax practices of small companies in Colombia. In the other hand, describes the main matters faced by small business whose because of it's structure, tend to be linked with “informal market” taking into account that this sector has been defined as those who realize many activities legally exclude or out of the taxable field. In that order of ideas, grocery stores are known as business operating on a low scale, wich are integrated for employees working independently, also in most of cases, hire friends or family members in an informal way. From the theoretical component, research is supported by the Stakeholder theory proposed by Freeman, which establishes that organizations generate externalities to the communities in which they are immersed, from a biunivocal relationship, since communities also they make organizations configure themselves around their needs. From the methodological aspect, the research is mixed positivist with a descriptive approach and simple random sampling has been used as a strategy for the selection of the sample. After analyzing the information, it is concluded that formal accounting and tax practices in the population under study are almost nil, and the cause of this problem is the lack of knowledge in accounting, finance and taxation they have, as well as the insufficient mechanisms of control and support of government agencies to this population.
Global dynamics of a fourth-order parabolic equation describing crystal surface growth
Authors: Duan Ning , Xu Xianyun
Published: February 2019

In this paper, we study the global dynamics for the solution semiflow of a fourth-order parabolic equation describing crystal surface growth. We show that the equation has a global attractor in H4per(Ω) when the initial value belongs to H1per(Ω).
Normal form of double-Hopf singularity with 1:1 resonance for delayed differential equations
Authors: Wu Xiaoqin P. P. , Wang Liancheng
Published: February 2019

In this manuscript, we provide a framework for the double-Hopf singularity with 1:1 resonance for general delayed differential equations (DDEs). The corresponding normal form up to the third-order terms is derived. As an application of our framework, a double-Hopf singularity with 1:1 resonance for a van der Pol oscillator with delayed feedback is investigated to illustrate the theoretical results.
A nonlinear control system with a Hilfer derivative and its optimization
Authors: Kamocki Rafał
Published: February 2019

In this work, we consider a fractional optimal control problem (FOCP) containing a nonlinear control system, described by a differential equation involving a Hilfer derivative, and an integral cost functional. We study the existence and uniqueness of a solution of the control system as well as the necessary and sufficient optimality conditions of FOCP.
Potenciales candidatos antimaláricos y antiplasmodiales de origen natural y sintético
Authors: Mesa Vanegas Ana María
Published: February 2019

La malaria es la enfermedad parasitaria más grave y extendida que enfrenta la humanidad, debido a su prevalencia, virulencia y al desarrollo de cepas resistentes a los medicamentos de uso común como la cloroquina. La falta de nuevos medicamentos asequibles son los factores limitantes en la lucha contra la malaria, por lo que hay una necesidad continua de investigación para nuevas clases de agentes antimaláricos. Una generación de moléculas activas contra Plasmodium basadas en el mecanismo de biocristalización del grupo hemo o en procesos metabólicos que ocurren en el parásito con los medicamentos de uso actual están siendo sintetizados y actualmente se encuentran en procesos de estudios in vitro, in vivo y estudios clínicos fase I y fase II. Esta revisión realiza una clasificación de los nuevos antimaláricos potenciales y sus modos de acción reportados en las últimas dos décadas con el fin de proporcionar una mirada al progreso significativo en el desarrollo de nuevos medicamentos antimaláricos.
Avaliação teórica do uso do oxihidróxido de vanádio trivalente na detecção eletroquímica de nandrolona
Authors: Tkach Volodymyr , Ivanushko Yana G. , Lukanova Svitlana M. , De Oliveira Sílvio C. , Anaissi Fauze J. , Storoshchuk Nataliia M. , Yagodynets´ Petro I.
Published: February 2019

Pela primeira vez foi descrito um caso interessante de uso do oxihidróxido de vanádio trivalente (VO(OH)) como modificador de elétrodo na detecção eletroquímica de nandrolona. Foi mostrado que o oxihidróxido de vanádio pode ser um modificador eficiente para a detecção de nandrolona, mas, ao contrário da maioria dos casos de uso de oxihidróxido de cobalto, composto parecido, o processo é catódico e dá-se em meio moderadamente ácido a neutro. O comportamento oscilatório, no sistema, é possível apenas por causa das influências do processo da eletrorredução de vanádio tetravalente em trivalente na dupla camada elétrica.
The Effect of Intelligence Quotient and Emotional Quotient on Employee Performance at Pt. Karna Titian Sejahtera Denpasar
Authors: Widyawati Sapta Rini , Karwini Ni Ketut
Published: February 2019

The purpose of this study was to determine the effect of intelligence quotient and emotional quotient on employee performance at PT. Karna Titian Sejahtera Denpasar. The design of this study is causal research which investigates the relationship between variables, which are independent the variables are intelligence quotient (X1) and emotional quotient (X2) and k inerja employees (Y) as the dependent variable. Determination of the sample in this study using a census, which is if all members of the population as many as 34 people used as samples. Data analysis using SPSS V.23 software . The analysis technique used is multiple linear regression, multiple correlation, determination, t test and F test. The result is that intelligence quotient has a positive and significant effect on employee performance, emotional quotient has a positive and significant effect on employee performance, intelligence quotient and emotional quotient simultaneously have a positive and significant effect on employee performance at PT. Karna Titian Sejahtera Denpasar.
The role of CD68 positive tam in development of non-small cell lung cancer
Authors: Minkov Pl. , Gulubova M. , Obretenov E. , Ananiev J.
Published: February 2019

Non-small cell lung cancer (NSCLC) is a leading cause of cancer related mortality. Main factors of development of NSCLC are many immune cells involved in tumor microenvironment. Infiltration with CD68 positive tumor associated macrophages (TAM) in the tumor stroma or in the tumor islets is associated with prognosis and stage of the disease for a long time. Investigating immunohistochemically 40 patients with NSCLC we discovered that 25% of patients with metastasis in lymph nodes had low infiltration with TAM in the tumor border, while 35.7% of the patients without metastasis- the infiltration was high (х2=5.19; р=0.023). We also discovered that all patients in stage I and 66.7% of the patients in stage II had low infiltration with TAM in the tumor border, while 100% of those in stage IV had high infiltration in the border (x2=5.44; p=0.02). In addition, we observed that 52.9% of the patients in T3-4 the infiltration of the tumor border with TAM was high, while only 16.7% of those in T1-2 had high infiltration (x2=2.92; p=0.087). In investigated by our team lung cancers, clear associations were established between CD68 positive cells density in the tumor border and stage of the disease.
Transient simulation study of floor heating systems
Authors: Horka Lucie , Hirs Jiri
Published: February 2019

This case study is aimed at transient simulation of floor heating systems. There is comparison of surface floor temperatures and heat fluxes changes of different systems over time. The first studied system is a dry floor heating system which consists of system boards made from insulation material, spreader plates, and it is covered by cement fiber boards. The second examined system is heavy wet concrete floor heating system whose heating power is set identically as heating power of dry floor heating system. Mean temperature of heating water is investigated. All simulations, both time steady-state and transient, are performed in software CalA. Reduction of duration and computational performance of simulation is achieved by creation of a surrogate model. The surrogate model evinces identical surface temperatures and heat fluxes. Total number of computational grid is reduced and therefore lower number of equations is solved. Results show that dry floor heating system has faster response than concreate floor heating system. It is caused by lower weight and lower thermal capacity of this system.
An innovative approach for harmonising availability and energy efficiency in data centres: A case study
Authors: Kunbaz Mahmoud , Bieser Jürgen
Published: February 2019

A Data Centre (DC) as critical, energy-hungry infrastructure is dominated by two main driving forces: i) Availability and ii) Energy requirements. As a result of increasing energy costs, algorithms for optimising energy efficiency have been devised. However, these algorithms do not take availability into consideration.

This paper aims to present a combination of Failure Mode, Effects and Criticality Analysis (FMECA)/Reliability, Availability, Maintainability (RAM)/Energy Analysis as an innovative approach for harmonising availability and energy efficiency in DC. Based on various measures defined by FMECA/RAM, corresponding availability and reliability are modelled and calculated. In parallel, potential energy saving measures are included in RAM simulation to quantify their influence on the availability and reliability of DC infrastructure. As a result, a set of the most promising optimisation measures is selected.

Results show that some energy saving measures are highly correlated with availability. However, required data centre availability can be achieved with improved energy efficiency if the right set of optimisation measures is implemented. This approach guides DC managers to identify improvement potentials in terms of availability and energy efficiency, providing a reliable decision basis for future investments.
PENERAPAN METODE PEMBELAJARAN PROBING PROMPTING DENGAN MEDIA GAMBAR UNTUK MENINGKATKAN KEAKTIFAN BELAJAR SISWA PADA MATA PELAJARAN PAI
Authors: Anwar Cecep , Yulianti Novi
Published: February 2019

Penelitian ini dilatarbelakangi oleh beberapa permasalahan yang terjadi di SMPN 1 Cariu Kecamatan Cariu Bogor dalam pembelajaran Pendidikan Agama Islam, salah satunya masih rendahnya keaktifan belajar siswa di kelas VII 8. Oleh karena itu, untuk meningkatkan keaktifan belajar siswa salah satu metode yang diasumsikan mampu meningkatkan keaktifan belajar siswa adalah metode pembelajaran probing prompting dengan media gambar. Penelitian ini bertujuan untuk mengetahui bagaimana keaktifan belajar siswa sebelum diterapkannya metode pembelajaran probing prompting dengan media gambar, penerapan metode pembelajaran probing prompting dengan media gambar, dan bagaimana peningkatan keaktifan belajar siswa setelah penerapan metode pembelajaran probing prompting dengan media gambar. Penelitian ini menggunakan Penelitian Tindakan Kelas (PTK) yang dilakukan dalam dua siklus. Masing-masing siklus meliputi empat tahap yaitu perencanaan, pelaksanaan, observasi dan refleksi. Penelitian dilaksanakan di kelas VII 8 dengan jumlah siswa 35 orang. Adapun istrumen yang digunakan yaitu silabus, RPP, lembar observasi guru dan siswa serta angket siswa. Hasil yang diperoleh pada penelitian ini terjadi peningkatan keaktifan belajar siswa. Siklus 1 hasil observasi keaktifan belajar siswa memperoleh persentase 73,28% dikategorikan aktif diperkuat dengan hasil angket keaktifan belajar siswa dengan persentase 76,19% dikategorikan aktif. Siklus II hasil observasi keaktifan belajar siswa memperoleh persentase 86,78% dikategorikan sangat aktif diperkuat dengan hasil angket keaktifan belajar siswa dengan persentase 84,41% dikategorikan sangat aktif.
URGENSI KOMUNIKASI DAN INTERAKSI DALAM KELUARGA
Authors: Sobandi Oban , Dewi Novianti
Published: February 2019

Tulisan ini bermaksud mengkaji bahwa komunikasi dan interaksi dalam keluarga itu sangatlah penting karena dapat berpengaruh terhadap pembentukan karakter anak dan juga keharmonisan sebuah keluarga. Maka selanjutnya perlu kiranya memperluas ilmu pengetahuan mengenai urgensi komunikasi dan interaksi dalam keluarga agar didapati pemahaman mengenai pola komunikasi yang baik dalam sebuah keluarga guna menciptakan keluarga yang bahagia, sejahtera dan harmonis. Pembahasan dimulai dari bahasan komunikasi efektif dalam keluarga, cara menumbuh kembangkan komunikasi dalam keluarga, sampai pada manfaat komunikasi dalam keluarga yang dapat menciptakan keluarga sejahtera. Point pembahasan disampaikan bertujuan agar didapati mengenai urgensi komunikasi dan interaksi dalam keluarga itu sendiri. Pendekatan kajian dalam tulisan ini dianalisis berdasarkan perspektif pendidikan Islam baik berdasarkan analisis teoretik maupun empirik.
Curriculum Development, Islamic Religious Education, Islamic Elementary School AL Azhar
Authors: Hilman Maas Piki
Published: February 2019

The Islamic Education curriculum is one of the important components to create a generation of morality and martyrs. But the Islamic Religious Education curriculum has been considered only to educate cognitive aspects (transfer of knowladge) and has not touched many affective and psychomotor aspects (transfer of value). This is evident from the many students who have not been able to apply knowledge about their religion such as not performing worship well, speaking harshly and disrespectfully, disrespecting parents and teachers and a group of students who are often in shopping centers and crowds. Therefore, it is necessary to develop an Islamic Education curriculum that accommodates cognitive, affective and psychomotor aspects, so that education is not only a transfer of knowladge but also a transfer of value. Islamic Education curriculum development in this study contains the understanding of the expansion or improvement of the subject matter of the Islamic Religious Education curriculum and what is experienced by students or all efforts (engineering) programmed by Al Islam Azhar 36 Bandung in helping develop the potential of students through learning experience the potential to achieve the vision, mission, school goals.
THE STRATEGY OF STUDENTS ENTREPRENEURING THROUGH RELIGIUS CULTURAL PROGRAMS
Authors: Nurdiana Wahyu
Published: February 2019

This study aims to: 1) Know the strategy of moral coaching students in SMPN 3 Cikupa and SMP Al-Fattah Tigaraksa Tangerang. 2) To know the implementation of the moral guidance strategy of students through religious culture program at SMPN 3 Cikupa and SMP Al-Fattah Tigaraksa Tangerang. 3) Knowing what the supporting and inhibiting factors in the implementation of moral strategy of students through religious culture program in SMPN 3 Cikupa and SMP Al-Fattah Tigaraksa Tangerang. 4) Knowing the results of the implementation of moral coaching strategies through religious cultural programs to moral coaching students at SMPN 3 Cikupa and SMP Al-Fattah Tigaraksa Tangerang. The method used in this research is descriptive-qualitative with the form of field research approach (field research) or case study (case study). The data used are qualitative data. The data sources used consist of primary data sources and secondary data sources. The data collection is done by observation, interview, documentation and bibliography.
Transient Heat Transfer in Dental Implants for Thermal Necrosis-Aided Implant Removal: A 3D Finite Element Analysis
Authors: Gungormus Mustafa , Erbasar Guzin Neda Hasanoglu
Published: February 2019

Removal of osseointegrated but otherwise failed (mechanical failure, mispositioning, esthetics, etc) dental implants is a traumatic process resulting in loss of healthy bone and complicating the treatment process. The traumatic effects of implant removal can be reduced by weakening the implant-bone attachment. Thermal necrosis-aided implant removal has been proposed as a minimally invasive method toward this end. In this method, an electrocautery tip is contacted to the implant to increase the temperature to 47°C and generate a limited and controlled thermal necrosis at the bone-implant interface. So far, no controlled studies have been performed to investigate the optimal clinical parameters for this method. In this study, we aimed to investigate, using finite element analysis method, the optimal settings to achieve intentional thermal necrosis on 3 implant systems, at 5 W and 40 W device power and with different size tips. The temperature increase of the implants at 40 W power was very sudden (< 0.5 seconds) and as the bone reached 47°C, the implants were at unacceptable temperatures. At 5 W power, temperature increase of the implants happened at manageable durations (< 1 second). Moreover, the temperature increase was even slower with larger implants and larger tip sizes. Therefore, low power settings must be used for thermal necrosis-aided implant removal. Also, the size of the implant and the tip must be taken into consideration in deciding the duration of contact with the electrocautery tip and the implant.
Logical Foundations of Linked Data Anonymisation
Authors: Grau Bernardo Cuenca , Kostylev Egor V.
Published: February 2019

The widespread adoption of the Linked Data paradigm has been driven by the increasing demand for information exchange between organisations, as well as by regulations in domains such as health care and governance that require certain data to be published. In this setting, sensitive information is at high risk of disclosure since published data can be often seamlessly linkedwith arbitrary external data sources.In this paper we lay the logical foundations of anonymisation in the context of Linked Data. We consider anonymisations of RDF graphs (and, more generally, relational datasets with labelled nulls) and define notions of policy-compliant and linkage-safe anonymisations. Policy compliance ensures that an anonymised dataset does not reveal any sensitive information as specified by a policy query. Linkage safety ensures that an anonymised dataset remains compliant even if it is linked to (possibly unknown) external datasets available on the Web, thus providing provable protection guarantees against data linkage attacks. We establish the computational complexity of the underpinning decision problems both under the open-world semantics inherent to RDF and under the assumption that an attacker has complete, closed-world knowledge over some parts of the original data.
Penentuan Nilai Jarak Aman Sumber Tidak Bergerak: Skenario Kebakaran dan Ledakan pada SPBU dan SPPBE di Sekitar Tapak RDE
Authors: Priambodo Dedy
Published: February 2019

PENENTUAN NILAI JARAK AMAN SUMBER TIDAK BERGERAK: SKENARIO KEBAKARAN DAN LEDAKAN PADA SPBU DAN SPPBE DI SEKITAR TAPAK RDE. Nilai jarak aman (Screening Distance Value, SDV) untuk tiap-tiap jenis sumber bahaya harus ditentukan menggunakan pendekatan konservatif sehingga pengaruh kejadian interaksi yang berada di luar jarak ini tidak perlu diperhitungkan lebih lanjut. Dari pengamatan, sumber tidak bergerak yang paling banyak berada di sekitar tapak adalah Stasiun Pengisian Bahan Bakar Umum (SPBU) dan Stasiun Pengangkutan dan Pengisian Bulk Elpiji (SPPBE). Oleh karena itu, penelitian ini bertujuan untuk menentukan SDV dari SPBU dan SPPBE untuk skenario ledakan dan kebakaran dengan lokasi studi di sekitar tapak Reaktor Daya Eksperimental (RDE), Puspiptek Serpong. Studi ini menggunkan Areal Location Of Hazardous Atmospheres (ALOHA) untuk mensimulasikan zona ancaman ledakan dan kebakaran dari substansi Bensin dan LPG. Simulasi ini melibatkan ledakan dan kebakaran iso-oktana di  SPBU dan butane di SPPBE untuk menganalisis zona ancaman dari skenario kecelakaan. Diketahui bahwa SDV sangat tergantung dari jenis, maupun kapasitas material berbahaya, skenario kecelakaan serta kondisi atmosfer pada sumber bahaya tersebut. Dari penelitian ini, diketahui pula suatu sumber bahaya bisa mempunyai SDV lebih dari satu nilai. SDV SPBU berkapasitas 170.000 liter untuk skenario kebakaran 976 m dan 1.200 m, sedangkan untuk skenario ledakan adalah 958 m dan 1.200 m. SDV SPPBE berkapasitas 25.000 kg untuk skenario kebakaran 445 m dan 565 m, sedangkan untuk skenario ledakan adalah 430 m dan 573 m. Sementara SDV SPPBE berkapasitas 100.000 kg untuk skenario kebakaran 913 m dan 1.100 m, sedangkan untuk skenario ledakan adalah 758 m dan 1.100 m. Studi ini dapat memberikan alternatif penentuan nilai SDV pada studi dan evaluasi tapak reaktor nuklir.
Pengaruh Perisai Radiasi Pada Penyimpanan Kering Bahan Bakar Nuklir Bekas untuk Reaktor Daya Eksperimental
Authors: Artiani Pungky Ayu , Ratiko Ratiko , Purwanto Yuli , Heriyanto Kuat
Published: February 2019

PENGARUH PERISAI RADIASI PADA PENYIMPANAN KERING BAHAN BAKAR NUKLIR BEKAS UNTUK REAKTOR DAYA EKSPERIMENTAL Di masa mendatang, Badan Tenaga Nuklir Nasional (BATAN) berencana membangun Reaktor Daya Eksperimental (RDE) dengan daya termal 10 MW. RDE merupakan merupakan reaktor suhu tinggi dengan bahan bakar berupa pebble yang teknologinya mirip dengan reaktor HTR-10. Dalam operasional RDE hal yang perlu diperhatikan adalah pengelolaan Bahan Bakar Nuklir Bekas (BBNB). Oleh karena itu, teknologi pengelolaan BBNB HTR-10 dapat digunakan sebagai acuan dalam pengelolaan BBNB reaktor RDE. Pengelolaan BBNB reaktor HTR-10 disimpan dalam tangki penyimpanan dengan sistem kering. Telah dilakukan perhitungan laju dosis pada tangki penyimpanan BBNB di gedung reaktor dan interim storage menggunakan Monte Carlo N-Particle 5 (MCNP-5). Hasil perhitungan laju dosis pada tangki penyimpanan dengan berbagai ketebalan timbal (Pb) berkisar 11,7 – 2,560 x 106 µSv/jam dan 813,06 – 7,146 x 106 µSv/jam masing-masing pada gedung reaktor dan interim storage. Hal ini menunjukkan bahwa ketebalan Pb pada tangki penyimpanan tidak memberikan pengaruh yang signifikan dalam penurunan laju dosis baik pada gedung reaktor maupun interim storage. Penurunan laju dosis akan lebih efektif dengan penambahan Pb pada shielding luar tangki penyimpanan BBNB. Hasil perhitungan laju dosis berkisar 2,560 x 106 – 20,32 µSv/jam dan 7,146 x 106 – 105,58 µSv/jam untuk berbagai ketebalan Pb pada shielding luar tangki penyimpanan BBNB masing-masing di gedung reaktor maupun interim storage.  Meskipun nilai laju dosis tidak memenuhi syarat Nilai Batas Dosis (NBD) bagi pekerja radiasi dan masyarakat, namun untuk keselamatan pekerja radiasi penanganan BBNB ini dapat diakomodir dengan konsep As Low As Resonably Achievable (ALARA), memperpanjang waktu peluruhan BBNB dan menfungsikan dinding interim storage sebagai shielding.Kata kunci : Reaktor Daya Eksperimental (RDE), Bahan Bakar Nuklir Bekas (BBNB), laju dosis, perisai radiasi.
Unjuk Kerja Pengangkutan Penumatik Sistem Small Adsober Sphere Shutdown System untuk Sistem Pemadaman Kedua RDE
Authors: Syahna Denissa Beauty , Priambodo Dedy - , Putro Guntur Eko
Published: February 2019

UNJUK KERJA PENGANGKUTAN PENUMATIK SISTEM SMALL ADSOBER SPHERE SHUTDOWN SYSTEM UNTUK SISTEM PEMADAMAN KEDUA RDE. Reaktor Daya Eksperimental (RDE) adalah reaktor berbendingin gas temperatur tinggi yang merupakan program unggulan BATAN untuk mempromosikan penggunaan energi nuklir, meningkatkan penerimaan masyarakat terhadap energi nuklir, membuktian kehandalan system keselamatan dari teknologi reaktor maju, menguasaan teknologi reaktor generasi IV dan mendorong kemampuan industri nuklir nasional. RDE menggunakan Small Adsorber Sphere Shutdown system (SAS) sebagai system kedua pemadaman reaktor. SAS terdiri atas elemen SAS (B4C) 5mm sebanyak 270.000 buah,  sistem pengangkutan penumatik dan bejana penyimpanan elemen SAS. Studi ini bertujuan untuk mengetahui unjuk kerja sistem pengangkutan penumatik elemen SAS dengan parameter yang ditinjau adalah target waktu pengangkutan sebesar 100, 120, 140, 160, 180 dan 200 detik serta diameter pipa pengangkutan sebesar 40mm, 50mm, dan 60mm. Dari studi diketahui bahwa penurunan tekanan terbesar terjadi pada diameter pipa 40mm dan target waktu pengangkutan elemen SAS 100 detik yaitu sebesar 2.3psi; sedangkan penurunan tekanan terendah diperoleh pada diameter 60mm dan target waktu pengangkutan elemen SAS 200 detik yaitu sebesar 0.7 psi.Kata kunci: Unjuk kerja, pneumatik, SAS, RDE, Diameter, waktu-pengangkutan
Penerimaan Masyarakat Sekitar Puspiptek Serpong Terhadap Rencana Pembangunan Reaktor Daya Eksperimental
Authors: Mudjiono Mudjiono - , Alimah Siti - , Susiati Heni - , Irawan Dimas - , Bustomi Moh.
Published: February 2019

PENERIMAAN MASYARAKAT SEKITAR PUSPIPTEK SERPONG TERHADAP RENCANA PEMBANGUNAN REAKTOR DAYA EKSPERIMENTAL. Rencana pembangunan Reaktor Daya Eksperimental (RDE) selain didasarkan pertimbangan aspek tekonologi dan keselamatan, juga didasarkan aspek sosial, ekonomi, budaya maupun lingkungan. Berdasar aspek sosial, rencana pembangunan tersebut dapat dimaknai berbeda-beda di dalam masyarakat berdasar tingkat pengetahuan dan persepsi masing-masing. Tujuan studi untuk mengetahui tingkat peneriman masyarakat sekitar kawasan terhadap pembangunan RDE. Metodologi yang digunakan dengan studi literatur selanjutnya dilakukan pengambilan sampel melalui survei dengan responden yang proporsional. Dari hasil analisis kuesioner menunjukkan bahwa 64% responden menyatakan mengetahui BATAN telah mengoperasikan reaktor nuklir, sementara tidak tahu 19% dan yang tidak menjawab sebesar 17%. Sebagian besar responden menyatakan bahwa sumber informasi pengetahuan tentang BATAN diperoleh dari keikutsertaannya di acara diskusi sebesar 18,7%, selanjutnya 17,7% melalui TV dan penyuluhan sebesar 16,3%. Terdapat 75% dari Responden yang menyatakan setuju terhadap rencana pembangunan RDE untuk memenuhi kebutuhan listrik, sedangkan yang tidak setuju sebesar 7% dan tidak menjawab sebesar 18%. Responden beranggapan bahwa dengan adanya RDE akan menyebabkan harga listrik akan menjadi murah (20,3%), dapat menciptakan lapangan kerja (19,2%) dan RDE dipahami tidak mengeluarkan polusi (17,5%). Sedang ketidaksetujuan dikarenakan ada kekhawatiran terjadi kecelakaan atau kebocoran, pencemaran radioaktif dan beranggapan bahwa pembangkit tenaga listrik  lain masih mencukupi.Kata kunci: Penerimaan masyarakat, survei, RDE
Classroom Reflections of Model-Based Instruction: Ace Teaching Cycle
Authors: KILIÇOĞLU Elif , KAPLAN Abdullah
Published: February 2019

Aim of this study was to reveal
reflections of the instruction process based on ACE (Activity, Class
Discussion, Exercises) teaching cycle. The study was carried out with 7th
graders in a public middle school on equations in 2014-2015 academic year. This
quasi-experimental study lasted for 20 hours in total. The whole implementation
process was videotaped, and the records were transcribed by the researcher and
was written as a document. The obtained documents were analyzed through content
analysis. Consequently, it was revealed from the classroom reflections that the
students could express their ideas easily, they could question their incorrect
or incomplete ideas without hesitation, they learnt how to act with reference
to these incomplete ideas, they perceived that incorrect ideas are as important
as the correct ones, different approaches were precious and different
approaches could emerge for all circumstances.
Betriebseinrichtungen mit Sicherheitsfunktion im PLS
Authors: Gabriel Thomas , Hablawetz Dirk , Kartenberg Michael , Krauß Michael , Menck Udo , Schmitt-Pauksztat Gregor
Published: February 2019

In der zweiten Ausgabe der IEC 61511 sowie der überarbeiteten VDI/VDE 2180 werden Maßnahmen zur Umsetzung von risikoreduzierenden Funktionen im Leitsystem beschrieben. Im vorliegenden Artikel wird eine mögliche Implementierung dieser Maßnahmen im betrieblichen Leitsystem erörtert.
NOA – Von Demonstratoren zu Pilotanwendungen
Authors: De Caigny Jan , Tauchnitz Thomas , Becker Ronny , Diedrich Christian , Schröder Tizian , Großmann Daniel , Banerjee Suprateek , Graube Markus , Urbas Leon
Published: February 2019

Das Konzept Namur Open Architecture (NOA) wurde auf der Namur-Hauptsitzung 2016 vorgestellt, im Jahr 2017 gab es erste Demonstratoren. Inzwischen werden drei konkrete Elemente des NOA-Konzeptes erarbeitet: Die NOA-Diode sorgt für den sicheren Datenexport aus der Namur-Pyramide, das NOA-Informationsmodell beschreibt die Daten und Bezeichnungen, und Verification of Request erlaubt einenkontrollierten Datenfluss zurück in das Prozessleitsystem der Anlage. Diese Elemente wurden an der IGR-Testanlage im Industriepark Höchst implementiert. Im Beitrag werden vier konkrete Anwendungsfälle für die NOA-Bausteine vorgestellt: eine Pumpendiagnose, die automatische Aktualisierung der Dokumentation nach einem Sensortausch, die Online-Überwachung eines Prozessanalysegerätes sowie ein Dimensionierungs-Check für Feldgeräte.
Türkiye mantar üretimi ve ARIMA (Box-Jenkins) ile projeksiyonu
Authors: KURT Rıfat , KARAYILMAZLAR Selman
Published: February 2019

Artan nüfus ile birlikte alternatif besin kaynaklarına olan gereksinim giderek önem kazanmıştır. Mantar, uygun şartların sağlanması durumunda yıl boyunca birden fazla ürün alınabilen, kolay yetiştirilebilen ve besin değeri yüksek bir ürün olmasının yanında, doğada mevsimine bağlı olarak kendiliğinden yetişebilen ve kırsal alanda yaşayan insanların besin ihtiyacını karşılayan önemli bir gıda maddesidir. Bu çalışmada, Türkiye’nin mantar üretimi incelenmiş ve Türkiye mantar üretiminin gelecekteki durumunu belirlemek amacıyla tahmin yapılmıştır. Bu kapsamda, 1985-2016 yılları arasındaki verilerden yola çıkarak gelecek on yıllık mantar üretim değerleri ARIMA (Box-Jenkins) yöntemi ile tahmin edilmiştir. Sonuçlar, Türkiye mantar üretiminin kademeli bir şekilde artarak 2025 yılında 100 bin tonu aşacağını göstermiştir.
THE ROLE OF THE NOBILITY OF NORTH-EASTERN HUNGARY IN THE ESTABLISHING OF PROTESTANTISM
Authors: Ferkov O.
Published: February 2019

The article focuses on the problems of the participation and role of the nobility of North-Eastern Hungary in the process of spiritual renewal, caused by the Reformation. New ideological and spiritual trends have embraced the entire Hungarian society, however, not every social group responded equally to the challenges of time. Among the first aristocrats and nobility who accepted the teachings of Luther and made significant efforts for the establishment of the Reformation in North-Eeastern Hungary were: Perenii, Dragphi, Bebeki, Druget, Batory, Magochi and others. Following large landowners, the medium and small gentry and large masses of ordinary people of various ethnic groups quickly joined the camp of Reformation.

The main activity of gentry-Protestants were focused on the philanthropy and patronage. Material support and government patronage contributed to the opening and successful functioning of schools, the training of successful young people abroad, book publishing, etc.

For the establishment of the Reformation at the lands of modern Transcarpathia the main role had the Druget’s – the landlords of Uzhanshchyna and Zempinshchina and Uzhhorod. Under the patronage of Druget’s from 1546, the Protestant community already existed in Uzhhorod.

The author observes that the limited source material and the engagement of some individual authors, the problem is not sufficiently studied. Hungarian and Slovak authors have some research, but for national historiography the theme is "terra incognita". It is the task of the proposed article – join to highlight the issue.