bluuebunny/crossref_metadata_2025 huggingface dataset:
Perencanaan Sewerage System dan Instalasi Pengolahan Air Limbah (IPAL) Domestik Kawasan Universitas Malahayati Dengan System Wastewater Garden
Authors: Pradana Angga Arya , Wulandari Diah Ayu , Temenggung Muhtadi Arsyad
Published: February 2025

Malahayati University is one of the private universities in the city of Bandar Lampung every year receiving thousands of students. All domestic wastewater originating from the Malahayati University area has not been technically treated. The purpose of this research is to be able to plan a domestic Wastewater Treatment Plant (IPAL) in the Malahayati University Area that produces wastewater output in accordance with quality standards, Minister of Environment Regulation No. 68 of 2016 concerning domestic wastewater quality standards. The research method used is descriptive method and literature study with theoretical basis and wastewater concentration in Permen LHK No 68 of 2016 concerning domestic wastewater quality standards.Based on the research, the wastewater generated is 720 m3/day, the planned sewerage is 4 segments. In the weighting matrix of the three alternatives, Wastewater Garden was chosen as the WWTP processor, the land area for WWTP development was 758 m2. From the plan, it was obtained the estimated effluent, BOD 2.8 mg/lt, COD : 4 mg/lt, TSS : 3.2 mg/lt. while the Budget needed to build costs is Rp 1.551.813.000,00.
ABSTRAK
Universitas Malahayati merupakan salah satu Perguruan Tinggi Swasta di kota Bandar Lampung setiap tahunya menerima ribuan mahasiswa, Semua air limbah domestik yang berasal dari kawasan Universitas Malahayati belum dilakukan pengolahan teknis. Tujuan dari penelitian ini adalah dapat merencanakan Instalasi Pengolahan Air Limbah (IPAL) domestik di Kawasan Universitas Malahayati yang menghasilkan output air limbah sesuai dengan baku mutu, Peraturan Menteri Lingkungan Hidup No 68 Tahun 2016 tentang baku mutu air limbah domestik. Metode penelitian yang dipakai metode deskriptif dan studi literatur dengan dasar teori dan konsentrasi air limbah pada Permen LHK No 68 tahun 2016 tentang baku mutu air limbah domestik. Berdasarkan penelitian air limbah dihasilkan sebesar 720 m3/hari, Saluran air limbah yang direncanakan sebanyak 4 segmen. Dalam matriks pembobotan dari tiga alternatif, terpilih Wastewater Garden sebagai pengolah IPAL, didapatkan luas lahan pembangunan IPAL sebesar 758 m2. Dari perencanaan tersebut didapatkan perkiraan effluent, BOD 2,8 mg/lt, COD: 4 mg/lt, TSS: 3,2 mg/lt. sedangkan Anggaran Biaya yang butuhkan untuk membangun biaya sebesar Rp 1.551.813.000,00.
Does the chick of domestik chicken (Gallus gallus domesticus) in early development would able to witstand the injection of crude LPS?
Authors: Lelono Asmoro , Laensugi Agatha Dei Gratia , Arimurti Sattya
Published: February 2025

Preventing bacterial infections in poultry farms is a key aspect of effective disease management strategies. Enhancing innate immunity serves as a vital preventive measure in chicken farming. Lipopolysaccharide (LPS), a fundamental component of the bacterial cell wall, has been successfully utilized to boost the innate immune response in susceptible poultry hosts. This study focused on examining the impact of administering crude LPS from Salmonella typhimurium to a domestic chicken (Gallus gallus domesticus) strain during its early developmental stages up to the pre-maturation phase. Immune responses in the chicks were evaluated by observing changes in body temperature and leukocyte differentiation. The chickens were divided into two groups: control (injected with 0.85% NaCl) and treatment (injected with the LPS). The injections were applied in three different ages 7 days, 24 days, and 41 days. The body temperature and leukocyte differential data were collected following the LPS injection. Results showed a significant difference in body temperature and heterophil at the ages of 24 and 41, indicating an immune response characterized by inflammation and elevated heterophil levels. There was a significant increase in basal temperature during early development in line with chicks' development to maintain their homeostatic system. This study concludes that the chicks demonstrated resilience to the presence of LPS by exhibiting heightened responses. The increasing of heterophils concentration provided strong evidence of their immune capability to overcome bacterial infections
In Silico Study of Genus Marchantia using matK loci for DNA Barcoding
Authors: Farhan Abdillah Maulana , Ulum Fuad Bahrul
Published: February 2025

Marchantia is a genus of liverworts that can be found in the Asia-Europe Region. Some of the types that can be found are Marchantia polymorpha subsp. montivagans, Marchantia polymorpha subsp. ruderalis, Marchantia paleacea subsp. diptera. All of these species have different levels of kinship, this is due to differences in their nucleotide structure. The purpose of this study was to identify the intolerance between Marchantia species in genomic studies using the NCBI Database. The method used in this research is the collection of nucleotides on NCBI and then construction with Mega 11 software. The marker used in this study is Maturase K (matK), this is because the marker is very optimal in the identification of a molecular-based species. The results of this study are Marchantia paleacea subsp. diptera matK (MP 58 and MP 54) has the highest level of kinship with a score of 99 (Neighbor-Joining Tree) and 100 (Maximum Likelihood Tree) and the outgroup of this phylogenetic is Dumortiera hirsuta.
Keywords: Marchantia, matK, NCBI, Phylogenetic.
Analisis Stakeholders Dalam Pengelolaan Daerah Aliran Sungai Bedadung Kabupaten Jember
Authors: Murdiyanto Adhitya Ferdiansyah
Published: February 2025

Kerusakan DAS disamping faktor perubahan tata guna lahan disebabkan lainya oleh masalah institusi, hukum dan kelembagaan yang belum mengatur pada daerah aliran sungai (Nugroho, 2003) dalam (Mulyawan et al., 2022). DAS Bedadung merupakan salah satu 109 DAS Prioritas Nasional dengan  kondisi daya dukung DAS Bedadung termasuk dalam kategori yang daya dukung yang di pulihkan (Wibisono, 2021).  Dalam kurun waktu tahun 2019-2022 telah terjadi 141 kejadian bencana banjir di wilayah DAS Bedadung Kabupaten Jember. Kurangnya keseriusan pemerintah dalam pengelolaan DAS Bedadung Jember terlihat dari belum adanya dokumen perencanaan lintas sektor RPDAST dan rencana kontijensi DAS Bedadung. Karena banyaknya insttusi yang mengelola DAS Bedadung menimbulkan permasalahan dari perencanaan, pelaksanaan dan evaluasi DAS. Tujuan penelitian ini adalah mengkaji bagaimana peran setiap stakeholders dalam pengelolaan DAS Bedadung. Metode yang digunakan dalam penelitian ini menggunakan deduktif kualitaf. Metode analisis yang digunakan menggunakan analisis pemetaan aktor atau analisis stakeholders dengan dua variabel yakni tingkat kepentingan dan tingkat pengaruh. Tingkat kepentingan stakeholders diukur dengan menggunakan 4 indikator, sedangkan tingkat pengaruh diukur dengan menggunakan 3 indikator. Berdasarkan identifikasi stakeholders tersebut terdapat empat kategori stakeholders dengan 11 stakeholders yang berpengaruh dalam pengelolaan DAS Bedadung. Hasil dari analisis stakeholders dapat ditemukan empat kategori stakeholders yang paling berpengaruh adalah key player yang berasal dari BPDASHL Brantas Sampean, Cabang Dinas Kehutanan Jember dan Perhutani Kabupaten Jember. Di perlukannya upaya kolaborasi lintas sektor dalam pengelolaan DAS Bedadung dan di perlukannya koordinasi, integrasi sinkronisasi dan sinergi dalam pengelolaan DAS.
Analisis Perkembangan Wilayah Menggunakan Permodelan Citra VIIRS Night-Time Light Pada Kabupaten Jember
Authors: P Prasetiyo , Listyawati Ratih Novi , Fitriah Lailatul , Pratama Dhani Malik
Published: February 2025

Mengidentifikasi perkembangan wilayah dapat dilakukan dengan menggunakan berbagai pendekatan. Umumnya, tingkat perkembangan wilayah dilakukan dengan mentapkan pusat pertumbuhan menggunakan analisis Indeks Sentralitas dengan mempertimbangkan jumlah fasilitas, infrastruktur yang disesuaikan dengan kondisi masyarakat untuk menentukan hierarki pusat daerah. Namun, terdapat keterbatasan dengan Indeks Sentralitas, terutama ketepatan temporal dan spasial, karna mengacu pada data sensus yang tidak mewakili seluruh area secara real-time. Untuk itu, terdapat inovasi dalam melihat perkembangan wilayah menggunakan metode Visible and Infrared Imaging Radiometer Suite (VIIRS), yang merupakan salah satu instrumen di Suomi-NPP (National Polar-orbiting  Operational Environmental Satellite System Preparatory Project). Metode VIIRS memanfaatkan cahaya di malam hari karna adanya aktivitas masyarakat. Data tersebut selanjutnya diklasifikasikan menjadi delapan interval kelas di mana semakin besar angka kelas, semakin besar intensitas emisi cahaya dan dengan demikian semakin aktif penduduknya. Hasil analisis menunjukkan bahwa kecamatan dengan tingkat perkembangan wilayah tertinggi berada pada Kecamatan Kaliwates dan area Sumbersari. Sedangkan kecamatan dengan perkembangan wilayah terendah berada pada Kecamatan Arjasa, Kecamatan Jelbuk, Kecamatan Jombang, Kecamatan Mayang, Kecamatan Pakusari, serta Kecamatan Sukorambi.
Kata kunci: Perkembangan Wilayah, Visible and Infrared Imaging Radiometer Suite (VIIRS), Pusat Kegiatan
Perbandingan Melalui Pendekatan Hukum terhadap Hak Penyandang Disabilitas dalam Penyediaan Fasilitas: Indonesia, Amerika Serikat, dan Mesir
Authors: Kurnia Eyda
Published: February 2025

Aksesibilitas fasilitas umum bagi penyandang disabilitas merupakan isu krusial di berbagai negara. Penelitian ini bertujuan untuk membandingkan pendekatan hukum yang diadopsi oleh Indonesia, Amerika Serikat, dan Mesir dalam memastikan penyediaan fasilitas yang dapat diakses oleh penyandang disabilitas. Ketiga negara tersebut telah menerapkan pendekatan hukum yang berbeda. Indonesia mengandalkan peraturan khusus tertulis, Amerika Serikat menggunakan undang-undang komprehensif, dan Mesir menggabungkan unsur-unsur dari kedua pendekatan tersebut. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian yuridis normatif. Data primer diperoleh dari bahan hukum primer seperti undang-undang dan peraturan di ketiga negara. Data sekunder meliputi buku, jurnal ilmiah, artikel, dan karya ilmiah lainnya yang relevan. Hasil penelitian menunjukkan bahwa ketiga negara telah menunjukkan komitmen dalam memastikan aksesibilitas fasilitas bagi para penyandang disabilitas. Namun, masih terdapat berbagai tantangan dalam implementasi, seperti kesenjangan kepatuhan, mekanisme penegakan yang lemah, dan kurangnya kesadaran masyarakat.
Politik Hukum Dalam Program Legislasi Di Indonesia
Authors: Arfandy Muh Farhan , Maharani A Rafika
Published: February 2025

Penyusunan undang-undang yang demokratis harus menggambarkan peran hukum sebagai alat untuk memfasilitasi dinamika masyarakat. Dengan cara ini, peran hukum dalam negara yang sedang mengalami perubahan dapat mencakup semua kompleksitas masyarakat seperti Indonesia. Perkembangan teknologi dan industri menuntut kehadiran suatu kerangka hukum yang mampu mencapai tujuan yang diinginkan oleh masyarakat. Dalam artikel ini, akan dibahas tentang politik hukum dalam pembentukan undang-undang di Indonesia yang berkaitan dengan Konstitusi, sehingga dampaknya sesuai dengan yang diinginkan. Tujuan dari artikel ini antara lain, untuk mengetahui bagaimana aspek yang mempengaruhi legislasi di Indonesia, dan untuk mengetahui bagaimana Politik Hukum Legislasi di Indonesia.  Adapun metode penelitian yang akan digunakan menggunakan metode penelitian normatif dengan pendekatan konsep dan pendekatan perundang-undangan. Untuk menghasilkan kualitas yang berbeda dengan kualitas legislasi saat ini membutuhkan proses dalam menghasikan produk tersebut, yaitu undang-undang, tanpa perubahan dalam mekanisme tersebut maka tidak bisa lagi kita berharap terjadi perubahan kualitas dengan mesin proses yang sama. Kekuasaan politik yang dijalankan oleh pemerintah bersama lembaga-lembaga kenegaraan lainnya, harus sesuai dengan konstitusi yang telah disepakati bersama demi tegaknya negara hukum. Dalam hal ini semua komponen bangsa, baik organisasi politik, harus secara sadar melaksanakan kewajibannya sesuai dengan aturan hukum.
Role of Lactobacillus reuteri in human health
Authors:   Kazan State Medical University, Kazan, Russian Federation, Faizullina R.A. , Ukraintsev S.E. ,   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation,   Nestlé Russia LLC, Moscow, Russian Federation
Published: February 2025

The role that the gut microbiota plays in maintaining human health cannot be overemphasized. Numerous studies have shown that dysbiosis is associated with several pathological conditions. Some probiotic strains have proven to be effective both in improving the composition of the gut microbiota and in preventing or correcting certain pathological conditions. This review presents data on different strains of Lactobacillus reuteri, primarily an updated information on the efficacy of the probiotic strain L. reuteri DSM 17938 in the treatment and prevention of various human diseases.
Key words: Lactobacillus reuteri, Lactobacillus reuteri DSM 17938, probiotics, gut microbiota, colic, constipation, regurgitation
Diabetes associated with Shwachman–Diamond syndrome
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ipatova M.G. , Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: February 2025

Shwachman–Diamond syndrome (SDS) is a rare genetic disorder that belongs to the group of ribosomopathies and is caused by pathogenic variants in the SBDS gene. This syndrome includes disorders of hematopoiesis, exocrine pancreatic insufficiency, and bone system pathology. This article describes the first clinical case of SDS-associated diabetes in the Russian population in a 9.5-year-old boy.
Key words: Shwachman–Diamond syndrome, children, pancreas, diabetes
METHOD OF DETECTING LANDMARKS FOR NAVIGATION OF AUTONOMOUS MOBILE ROBOTS USING FEATURES OF AVERAGE COLOR INTENSITY DISTRIBUTION
Authors: Poliarus Oleksandr , Khomenko Yurii
Published: February 2025

The use of video cameras in the navigation of autonomous mobile robots is one of the possible ways of implementing passive remote methods of detecting ground landmarks. A method for detecting ground landmarks during the navigation of autonomous mobile robots was proposed, which is based on the features of the distribution of average color intensity in the columns of the video camera matrix of the autonomous mobile robot. The main feature of the distribution is manifested in the fact that when a pillar-like object appears in the field of view of the video camera as a possible landmark, a jump or dip appears in it, the amplitude of which can serve as a criterion for landmark detection. The work shows that this operation can be effectively performed on the basis of the image matrix analysis, if the color of the landmark is significantly different from the color of the background image. In other cases, it is proposed to use the averaging of the intensity of red, green, and blue colors along the columns of the video camera matrix. The specified method to increase the probability of landmark detection in the broad conditions of application of a video camera of an autonomous mobile robot is proposed to use as a detection criterion the product of the modulus of the derivative of the distribution of average colors in the columns of the matrix by the modulus of the difference of the specified distribution and its average value across all columns. It was established that the product of the module of the specified derivative by the module of the difference between the distribution of average colors and the average value of this distribution, which is called the determining product, can serve as a criterion for identifying a landmark. It is shown that exceeding the maximum value of the determining product above the threshold value, which is determined based on the analysis of statistical data, in any of the channels of red, green, and blue colors indicates the detection of a ground landmark. Research data show that the determining product in its influence on the probabilistic characteristics of detection is similar to the signal-to-noise ratio in radar.
SYNTHESIS OF DESIGN PARAMETERS OF MULTI-PURPOSE DYNAMIC SYSTEMS
Authors: Kutsenko Oleksandr , Alforov Mykhailo , Alforov Andrii
Published: February 2025

Two problems related to the optimization of linear stationary dynamic systems are considered. A general formulation of the multi-purpose problem of optimal control with the choice of design parameters is given. As a special case, the problem of multi-objective optimization of a linear system according to an integral quadratic criterion with a given random distribution of initial deviations is considered. The solution is based on the method of simultaneously reducing two positive-definite quadratic forms to diagonal form. Analytical results have been obtained that make it possible to calculate the mathematical expectation of the criterion under the normal multidimensional distribution law of the vector of random initial perturbations. The inverse problem of stability theory is formulated: to find a vector of structural parameters that ensure the stability of the system and a given average value of the quadratic integral quality criterion on a set of initial perturbations. The solution of the problem is proposed to be carried out in two stages. The first stage involves deriving a general solution to the Lyapunov matrix equation in terms of the elements of the system matrix. To achieve this, the state space is mapped onto the eigen-subspace of the positive-definite matrix corresponding to the integral quadratic performance criterion. It has been established that this solution is determined by an arbitrary skew-symmetric matrix or by the corresponding set of arbitrary constants. In contrast, when the system matrix depends linearly on the vector of design parameters, a linear system of equations can be formulated with respect to the unknown parameters and arbitrary constants present in the general solution of the inverse stability problem. In general, such a system is consistent and admits an infinite number of solutions that satisfy the initial requirements for the elements of the symmetric matrices in the Lyapunov.
SITUATIONAL MODEL OF A MEDICAL BUSINESS PROCESS
Authors: Petrov Kostiantyn , Chalyi Taras
Published: February 2025

The subject of the research is medical business processes. The aim of the work is to develop a situational approach to modeling a generalized medical business process. Achieving this goal makes it possible to provide a specified level of medical services within the existing resource constraints of the medical business process. To achieve the goal, the following tasks are solved: structuring medical business processes considering the differences in treatment in the clinic, care, and the full process of patient treatment; development of a situational model of the medical business process. The structuring of medical business processes has been carried out. It is shown that such processes consist of a clinical pathway, care pathway, and disease treatment pathway. The clinical pathway is implemented within a single medical institution. The care pathway defines a comprehensive description of the sequence of care and treatment. The complete disease treatment pathway integrates various healthcare institutions. The treatment pathway includes the clinical pathway and care pathway as subprocesses. A situational model of a generalized medical business process is proposed, consisting of a sequence of situations. Each situation involves a choice considering resource, financial, and temporal constraints, and the subsequent execution of a sequence of actions of the medical business process. The model, in accordance with the presented structuring of medical business processes, at the top level of representation contains phases of primary medical care, outpatient treatment, clinical pathway, and discharge and rehabilitation. The model creates conditions for choosing an individualized treatment process considering the patient's needs and temporal and resource constraints. The typical sequence of actions of the medical business process is determined at the level of a set of situations, and the choice of alternatives is made within the situation. The sequence of situations sets the general standard of care or treatment, and individualization is performed within individual situations, taking into account the patient's needs and financial constraints.
SOFTWARE DEVELOPMENT AND RESEARCH FOR MACHINE LEARNING-BASED STRUCTURAL ERRORS DETECTION IN BPMN MODELS
Authors: Kopp Andrii , Orlovskyi Dmytro , Gamayun Igor , Sapozhnykov Illia
Published: February 2025

The most important tool for process management is business process modeling. Business process models allow to graphically represent the sequences of events, activities, and decision points that make up business processes. However, models that contain errors in depicting the business process structure can lead to misunderstanding of a business process, errors in its execution, and associated expenses. Thus, the aim of this study is to ensure the comprehensibility of business process models by detecting structural errors in business process models and their subsequent correction. During the analysis of the Business Process Management (BPM) lifecycle, it was found that the created business process models do not have a stage of control for the presence of errors in them. Therefore, the paper analyzes and improves the BPM lifecycle using the proposed approach. In the improved BPM lifecycle, it is proposed to take into account the correctness validation stage of business process models using the developed software. The paper proposes to process created BPMN (Business Process Model and Notation) models as connected directed graphs. To detect errors in business process models, one of the Machine Learning methods, K-Nearest Neighbors, is chosen, which is a fairly simple and effective classification method. The study also includes the software design and development, its performance validation, and usage to solve the given problem. To analyze the obtained results, the confusion matrix was used and the corresponding quality metrics were calculated. The obtained results confirm the suitability of the developed software for detecting structural errors in business process models. This web application, which is based on the created classification model, allows all interested users to upload business process models in BPMN 2.0 format, view the uploaded models, and analyze them for structural errors.
De novo Genome Sequence of Roseibium alexandrii MAR44 Strain, a Marine Bacterium with Capacity to Synthesize PHA Bioplastics and a Photosynthesis Gene Cluster
Authors: García-Sánchez Susana , Soler Diego Saliente , Marín Anna , Cabedo Luis
Published: February 2025

We report here the genome sequence of Roseibium alexandrii strain MAR44, an alpha-proteobacterium isolated from an experimental device to monitor bioplastics colonization in the Mediterranean Sea. The genome assembly comprises a total of 5.25 Mb with a GC content of 56.33% and 5,019 predicted genes. Genome annotation reveals that MAR44 strain contains several pha genes involved in the polymerisation and depolymerisation of polyhydroxyalkanoates; phaA, phaB and phaC encode for the enzymes responsible of the last steps of the biosynthetic pathway, whereas phaZ encodes for a PHA-depolymerase. We also identified the phaR regulator and four phaP genes encoding for phasin proteins with a role in folding and accumulation of PHA in subcellular granules. In addition, we identified a photosynthesis gene cluster including the bch genes for the bacteriochlorophyll a synthesis and the puf operon encoding photosynthetic reaction centre and light-harvesting genes. In another manuscript we describe the efficient production of PHA by this strain under different conditions of carbon source supplementation and photosynthetic light.
Laser-Based Powder Bed Fusion Additive Manufacturing of Thinner Walls Through Re-melting
Authors: Mezghani Adnen , Nassar Abdalla R. , Simpson Timothy W.
Published: February 2025

In laser-based powder bed fusion (PBF-LB) additive manufacturing (AM), implementation of thin-walled structures (TWS) presents many advantages such as light weighting and increasing heat transfer efficiency in heat exchangers. However, PBF-LB AM of small features approaching the size of the melt pool, such as TWS, is associated with large geometric variability and increased defects. This is a consequence of using a global “contouring and filling” toolpath strategy which applies laser toolpaths irrespective of the feature size. Alternatively, it is hypothesized that a tailored laser toolpath strategy that incorporates adjusted laser scan paths allows for better control of the weld tracks to achieve thinner walls and reduce defects and build errors. To validate this hypothesis, we explore an alternative laser toolpath strategy specific to fabricating TWS via PBF-LB AM. We construct an implicit model of wall thickness as a function of laser parameters and wall inclination angle. Additionally, we quantify the effects of laser scan strategy, laser power, laser scanning speed, and inclination angle on through-porosity. Finally, we propose a generalizable method for finding the thinnest porosity-free wall achievable by using a non-dimensional enthalpy of welding approach.
Preclinical immunoPET imaging of thyroid-stimulating hormone receptor expression in thyroid cancer using [64Cu]Cu-NOTA-TSHR-Ab
Authors: Fu Wenhui , Parent Ephraim E. , Gleba Justyna J. , Knight Joshua A. , III John A. Copland , Cai Hancheng
Published: February 2025

Purpose The thyroid-stimulating hormone receptor (TSHR) is a cell-surface receptor predominantly expressed on benign and malignant thyroid cells, making it a viable target for developing radiotheranostics for metastatic thyroid cancer imaging and therapy. This study reports the radiosynthesis and preclinical evaluation of a 64Cu-labelled human antibody for positron emission tomography (PET) imaging of TSHR expression in thyroid cancer mouse models.
Methods Human anti-TSHR recombinant antibody K1-70™ (TSHR-Ab) was conjugated with a bifunctional chelator, 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA), and then labelled with [64Cu]Cu2+, yielding radiotracer [64Cu]Cu-NOTA-TSHR-Ab. The specificity and binding affinity of the radiotracer to TSHR-positive (THJ529TTSHR(+)) or wild-type (THJ529TWT) cells were assessed in vitro. A series of immnuoPET imaging with [64Cu]Cu-NOTA-TSHR-Ab were conducted in mice bearing dual-flank tumors (THJ529TWT on the left and THJ529TTSHR(+) on the right) at multiple time points (1, 2, 4, 18, 24, and 48 h) post-injection (p.i.). Radiotracer co-injection studies with varying doses of unlabelled (cold) TSHR-Ab (100, 50, 25, 0 µg) were studied to assess its effect on radiotracer uptake in tumors and off-target organs. Biodistribution and immunohistochemistry (IHC) were performed to verify the immnuoPET imaging results.
Results [64Cu]Cu-NOTA-TSHR-Ab was synthesised with a radiochemical yield of 46.89 ± 3.74%, radiochemical purity of 98.77 ± 0.89%, and specific activity >1.42 GBq/mg (n = 5). In vitro cell studies demonstrated [64Cu]Cu-NOTA-TSHR-Ab had high specificity and nanomolar affinity for THJ529TTSHR(+) cells, with a dissociation constant (Kd) of 4.74 nM and an inhibition constant (Ki) of 0.92 nM. The immnuoPET imaging studies showed that the radiotracer could reach tumor quickly and showed high uptake in TSHR-positive thyroid tumors (SUVmax: 3.63 ± 0.42, 3.82 ± 0.44, and 4.09 ± 0.56 at 18, 24, and 48 h p.i., respectively). Co-injection with cold TSHR-Ab at doses ranging from 25 to 100 µg effectively reduced background signals, especially in spleen, liver, and bone. Notably, a dose of 25 µg cold TSHR-Ab reduced off-target signals without affecting tumor uptake. The biodistribution and IHC analyses further supported PET imaging findings.
Conclusion TSHR-targeted radiotracer [64Cu]Cu-NOTA-TSHR-Ab was synthesized with high radiochemical purity. Our preclinical evaluation results demonstrate it is a promising radiotracer for PET imaging of TSHR-positive thyroid cancer, which may guide and monitor TSHR-targeted therapies. High radiotracer uptake in tumor, prolonged retention time, and favourable pharmacokinetics with the support of cold antibody co-injection, pave the way for the development of paired radiotherapeutics to treat TSHR-positive thyroid cancers.
The Role Of S100B Calcium-Binding Protein And Some Biochemical Markers In Early Detection And Progression Of Breast Cancer
Authors: Attawi Jamal . A. ALjabbar , Hailan Sarah Y. , Mohaibes Mohammed
Published: February 2025

Breast carcinoma is the most typical malignancy among women. Therefore, early detection with breast cancer is helpful for the treatment, although other markers are required to increase accuracy. The study's objectives were to determine the effects of these markers on patients with breast cancer and the role that immunoglobulins (IgG, IgM) and S100B levels play in early diagnosis and the ability to distinguish between benign and malignant breast cancers. There were a significant increase in levels of IgG, IgM, calcium, ALP and S100B in breast cancer women in comparison with pathological and healthy controls. While there were no significantly differ in levels of IgG, IgM, and S100B, when compared pathological controls to healthy controls. These values of IgG, IgM, and S100B can be used in differentiation between benign tumors from malignant breast tumors .While a significant decrease in 1,25(OH)2 Vitamin D, phosphorus patients with breast cancer in comparison with healthy controls .These values make these parameters highly significant for early diagnosis and progression of breast cancer.
Technology of grinding of bone feed flour particles by means of impact-toothed hammers
Authors: Iskakov Ruslan , Gulyarenko Alexandr
Published: February 2025

The object of research: technology for grinding particles of bone meal.
Investigated problem: intensive production of finely ground particles of bone meal.
The main scientific results: as a result of consideration of the theory and mechanics of destruction, the theory of crack formation and the Griffith theory, impact-toothed hammers were developed and patented. It was found that the penetration of impact-toothed surfaces of hammers into pieces of crushed material forms cracks. The size of cracks on bone raw material – eggshell, obtained by impact-toothed hammer, exceeds the crack obtained by impact-flat hammer, which occurred mainly due to the penetration of hammer teeth.
The area of practical use of the research results: feed preparation shops specializing in feed production.
Innovative technological product: technology for grinding particles of bone meal by intensive grinding with a crusher using impact-toothed hammers.
Scope of the innovative technological product: hammer mills.
Problems of integrating artificial intelligence with SCADA systems
Authors: Rustamova Samina , Rustamov Farhad
Published: February 2025

The object of research: This study examines the integration of artificial intelligence (AI) with SCADA (Supervisory Control and Data Acquisition) systems in power plants to enhance automation and operational efficiency.
Investigated problem: Key challenges include real-time data processing limitations, system incompatibilities, and security risks. The lack of standardized AI implementation frameworks further complicates seamless integration.
The main scientific results: AI-driven SCADA systems improve predictive maintenance, optimize energy management, and enhance decision-making. Machine learning models enable early fault detection and anomaly identification, reducing downtime and maintenance costs while improving system performance.
The area of practical use of the research results: The findings are applicable to industries using SCADA, including power generation, water distribution, and oil and gas. AI-SCADA integration enhances automation, efficiency, and predictive maintenance.
Innovative technological product: An AI-enhanced SCADA framework utilizing machine learning and advanced analytics to improve monitoring, anomaly detection, and system optimization.
Scope of the innovative technological product: This AI-integrated SCADA solution is applicable across industrial sectors, enabling smarter automation, enhanced security, and data-driven decision-making, particularly in energy and industrial automation
IBD-DISK AS A TOOL ESTIMATING THE PREVALENCE OF INFLAMMATORY BOWEL DISEASE-RELATED DISABILITY AND ASSOCIATED INFLUENCING FACTORS MOROCCO: A CROSS-SECTIONAL STUDY
Authors: Aourarh Benayad , Adioui Tarik , Berrag Sanaa , Nejjari Fouad , Aourarh Aziz , Tamzaourte Mouna
Published: February 2025

Introduction: IBD can cause physical, psychological, family and social impairments. Quality of life of IBD patients is usually worse than general population. The aim of our study is to evaluate the quality of life of IBD patients in a Moroccan center, to determine its influencing factors and to calculate a cut-off for this score.

Methods: This is a 6-month prospective study, both descriptive and analytic, conducted from November 2021 to April 2022, with patients followed on an out-patient basis or in consultation at our department. The IBD-Disk questionnaire was explained to the patients and completed by the same doctor.

Results: 100 patients were included. Median age of our patients was 45 [28.3-56] with an equal number of male and female participants. 72 patients (72%) had Crohns disease for 28 patients followed for UC (28%). Median score of IBD-disk was 21.5 [9.25 - 42]. In univariate analysis, there is a statistically very significant difference in the total score of the IBD-Disk between sexes (p=0.006), therapeutic classes (0.018), use of an immunosuppressant (0.001), and clinical remission. In multivariate analysis, only immunosuppression emerges as a factor associated with the IBD-disk score. Finally, the value of 36 have been determined as a cut-off. A score 36 matched with a patient in clinical remission.

Conclusion: Our study is the first in Morocco to use the IBD-Disk in assessing the quality of life of IBD patients. It showed that the disease significantly impacts the quality of life of our patients (mainly female and on immunosuppressants), both psychologically (energy and emotions) and sexually, whether they are being treated for CD or UC. A cut-off score of 36 was assessed and can be used in our daily practice as a score below which clinical remission could be defined.
ASSOCIATION OF CLINICO-EPIDEMIOLOGICAL AND BIOCHEMICAL PARAMETERS AFFECTING MATERNO- FETAL OUTCOME IN ACUTE LIVER INJURY AND FAILURE IN PREGNANCY
Authors:   Department of Gynaecology & Obstetrics and Medical Gastroenterology, PGIMS, Rohtak, Malhotra Vani , Malhotra Parveen ,   Department of Gynaecology & Obstetrics and Medical Gastroenterology, PGIMS, Rohtak, Mahaych Ravi ,   Department of Gynaecology & Obstetrics and Medical Gastroenterology, PGIMS, Rohtak, Singh Parul ,   Department of Gynaecology & Obstetrics and Medical Gastroenterology, PGIMS, Rohtak
Published: February 2025

Introduction:The presentation of liver disease in pregnancy is varied and ranges from asymptomatic elevation of transaminases to fatal liver failure which causes significant morbidity and even mortality.

Aims and Objectives:To analyse the association of clinical and biochemical parameters affecting maternal and fetal outcome in acute liver failure & acute liver injury in pregnancy.

Materials & Methods-It was a prospective observational study conducted over one year involving 135 pregnant patients between19- to 40-year-old with raised liver enzymes with or without coagulopathy or altered sensorium

Results: Our study demonstrates that pregnancy specific liver disorders are leading cause of abnormal liver function tests particularly in third trimester with most common cause being intra hepatic cholestasis of pregnancy and acute viral hepatitis and requires a multidisciplinary team consisting of obstetrician, neonatologist, intensivist and hepatologist as these disorders are associated with high fetal and maternal morbidity and mortality.
FROM HERITAGE SPIRIT TO GLOBAL PALATES: NAVIGATING THE DYNAMICS OF FENI INDUSTRY IN GOA
Authors:   Principal, Goa College of Hospitality and Culinary Education, Goa., DSouza Edgar
Published: February 2025

This research paper delves into the intricate landscape of the Feni industry in Goa, India, exploring its historical roots, contemporary challenges, and potential avenues for sustainable growth, with a specific focus on its integration into the tourism narrative. Recognized with a Geographical Indication (GI) status and titled as a Heritage Spirit, Feni symbolizes centuries of heritage and craftsmanship, embodying a unique blend of Eastern and Western influences. Employing a qualitative methodology, the study conducted site visits and in-depth interviews across various stages of Feni production, uncovering challenges in cultivation, processing, and marketing, both for cashew and coconut Feni. Findings highlight the industrys dynamic evolution, from the resistance to standardization to the untapped potential in maturation practices and waste disposal. The study emphasizes the need for standardized practices, branding strategies, and policy initiatives for sustainable development. Furthermore, it explores the decline in coconut Feni production and proposes strategies for promoting Goa as an Alcohol Tourism destination, intertwining cultural experiences with Feni consumption.
Clínica psicoanalítica. Contextos del decir del análisis
Authors:   Universidad de San Buenaventura Cali
Published: February 2025

Este es un libro necesario. Desde sus primeras páginas nos confronta con cuestiones ineludibles para cualquiera que vuelque su interés hacia la práctica del psicoanálisis. Cada capítulo reconduce nuestra mirada a ciertos elementos imprescindibles en el ir y venir de la práctica clínica en instituciones y en torno a temas socialmente relevantes. Uno de los principales méritos de los autores de esta compilación radica en integrar una veta clínica que sirve como coordenada reflexiva para el lector. En algunos casos, esto se observa en viñetas clínicas; en otros es evidente por abordar conceptos fundamentalmente clínicos en el sondeo de síntomas contemporáneos relacionados con elementos sociales actuales. En esencia, en estas páginas resuena la experiencia de los autores que hace eco mediante nociones que conviene tener presentes al aplicar técnicas del psicoanálisis en esquemas institucionales o al afrontar asuntos sociales vinculados a la violencia y al abuso sexual a mujeres y menores.
Relationship between remittances and carbon emissions: An evidence of top five remittance-receiving countries
Authors: Bahadur Khatri Bishnu , Raj Timsina Tirtha , Nath Sapkota Khila , Acharya Pradeep
Published: February 2025

This study examines the environmental effects of remittances in the five largest remittance-receiving countries (India, Mexico, China, the Philippines, and Pakistan) using panel data from 1990 to 2022 sourced from the World Development Indicators. The study employed a quantitative and analytical research design. Remittances are a critical component of economic stability in these countries, yet their impact on carbon emissions and environmental sustainability remains underexplored. The study utilized a dynamic ordinary least squares (DOLS) method to analyze study variables. Unit root and cointegration tests were performed to assess long-run relationships. A dynamic ordinary least squares (DOLS) (pooled estimation) results revealed that GDP per capita and trade openness have significant positive influences on CO₂ emissions. On the contrary, urban population has significant negative influences on CO₂ emissions. In contrast, remittances show no notable effect on CO2 emissions. Furthermore, the results show significant long-run cointegration among the variables, with GDP per capita, trade openness, and urban population identified as major drivers of CO2 emissions. These findings indicate that economic growth, trade liberalization, and demographic expansion are key drivers of environmental degradation, while the direct environmental impact of remittances appears minimal. The study recommends policymakers prioritize environmentally sustainable investments to align remittance-driven economic growth with global climate goals.
Estimation of Machine Learning–Based Models to Predict Dementia Risk in Patients With Atherosclerotic Cardiovascular Diseases: UK Biobank Study (Preprint)
Authors: Gu Zhengsheng , Liu Shuang , Ma Huijuan , Long Yifan , Jiao Xuehao , Gao Xin , Du Bingying , Bi Xiaoying , Shi Xingjie
Published: February 2025

BACKGROUND

The atherosclerotic cardiovascular disease (ASCVD) is associated with dementia. However, the risk factors of dementia in patients with ASCVD remain unclear, necessitating the development of accurate prediction models.

OBJECTIVE

The aim of the study is to develop a machine learning model for use in patients with ASCVD to predict dementia risk using available clinical and sociodemographic data.

METHODS

This prognostic study included patients with ASCVD between 2006 and 2010, with registration of follow-up data ending on April 2023 based on the UK Biobank. We implemented a data-driven strategy, identifying predictors from 316 variables and developing a machine learning model to predict the risk of incident dementia, Alzheimer disease, and vascular dementia within 5, 10, and longer-term follow-up in patients with ASCVD.

RESULTS

A total of 29,561 patients with ASCVD were included, and 1334 (4.51%) developed dementia during a median follow-up time of 10.3 (IQR 7.6-12.4) years. The best prediction model (UK Biobank ASCVD risk prediction model) was light gradient boosting machine, comprising 10 predictors including age, time to complete pairs matching tasks, mean time to correctly identify matches, mean sphered cell volume, glucose levels, forced expiratory volume in 1 second z score, C-reactive protein, forced vital capacity, time engaging in activities, and age first had sexual intercourse. This model achieved the following performance metrics for all incident dementia: area under the receiver operating characteristic curve: mean 0.866 (SD 0.027), accuracy: mean 0.883 (SD 0.010), sensitivity: mean 0.637 (SD 0.084), specificity: mean 0.914 (SD 0.012), precision: mean 0.479 (SD 0.031), and F1-score: mean 0.546 (SD 0.043). Meanwhile, this model was well-calibrated (Kolmogorov-Smirnov test showed goodness-of-fit P value>.99) and maintained robust performance across different temporal cohorts. Besides, the model had a beneficial potential in clinical practice with a decision curve analysis.

CONCLUSIONS

The findings of this study suggest that predictive modeling could inform patients and clinicians about ASCVD at risk for dementia.
Demographic and Socioeconomic Disparities in Telemedicine Utilisation Among Individuals with Type 2 Diabetes in Primary Care: A Systematic Review and Meta-Analysis (Preprint)
Authors: Alfarwan Nawwarah , Kontopantelis Evan , Panagioti Maria , Hassan Lamiece , Zghebi Salwa
Published: February 2025

BACKGROUND

Importance: Telemedicine has revolutionized the management of type 2 diabetes mellitus (T2DM) in primary care by improving access to healthcare services and enhancing health outcomes. Despite these advancements, it remains unclear whether telemedicine has reduced access inequalities among different demographic and socioeconomic groups.

OBJECTIVE

Objective: To investigate the most important demographic and socioeconomic factors associated with telemedicine use among individuals with T2DM in primary care.

METHODS

Design: Systematic review and meta-analysis.
Data sources: MEDLINE, EMBASE, PsycINFO, Google Scholar, SCOPUS, and CINAHL from inception to December 2023. The reference lists of eligible studies and other relevant systematic reviews were also searched.
Methods: We included observational and cohort studies that assessed the effects of telemedicine interventions on individuals with T2DM in primary care. The core outcome were the factors associated with telemedicine use, reported as adjusted odds ratios (AORs) with their 95% confidence intervals for each factor, using a random-effects model. Heterogeneity was quantified using the I² statistic, and publication bias was assessed. The protocol for this review was registered at PROSPERO (ID: CRD42024550410).

RESULTS

Results: Of the 3000 records identified, 16 studies involving 71 336 patients were included in the meta-analysis. Female patients had higher odds of using telemedicine than male patients (pooled OR: 1.053; 95% CI: 1.02 to 1.09). Older adults were significantly less likely to use telemedicine than younger adults (pooled OR: 0.979; 95% CI: 0.98 to 0.98). Compared to White patients, Black patients were less likely to use telemedicine (pooled OR: 0.55; 95% CI: 0.32 to 0.94), while no statistically significant differences were observed for Hispanic (pooled OR: 1.075; 95% CI: 0.36 to 3.24) or Asian participants (pooled OR: 0.56; 95% CI: 0.29 to 1.06). Patients with higher education levels had greater odds of using telemedicine than those with lower education levels (pooled OR: 1.681; 95% CI: 1.48 to 1.91).

CONCLUSIONS

Conclusion: This systematic review and meta-analysis provide evidence of significant disparities in telemedicine utilisation among men, older adults, black individuals and those with lower levels of education who have T2DM in primary care. Given that these groups are among the most vulnerable to T2DM, these disparities highlight the critical need for strategic interventions and robust policy that ensure telemedicine fosters equitable access to healthcare, while preventing further exacerbation of existing health inequalities.