bluuebunny/crossref_metadata_2025 huggingface dataset:
Prioritising National Competitiveness over Support for Democracy? Finnish Media Policy in the 21st Century
Authors:   Tampere University, Ala-Fossi Marko , Grönlund Mikko ,   University of Turku, Hellman Heikki ,   Tampere University, Lehtisaari Katja ,   Tampere University, Karppinen Kari ,   University of Helsinki, Nieminen Hannu ,   University of Helsinki
Published: February 2023

Ever since the launch of the World Press Freedom Index almost 20 years ago, Finland has always been among the top fi ve countries of that index. According to the annual Reuters Digital News reports, Finnish people also have the highest level of trust in the news media and one of the highest levels of press readership in the EU. Most of the media companies are doing quite well, while Google and Facebook have a much less dominant role in the advertising market than elsewhere in Europe. In this context, you might expect Finland to have a comprehensive and visionary media and communications policy to support democracy. However, our meta-study of Finnish media and communications policy based on two recent reportsto the Ministry of Transport and Communications, other earlier studies, along with official documents as well as statistical data suggests that is not the case. Our analysis shows that most decisions have been pragmatic ad hoc solutions serving economic interests rather than any specific media and communication policy goals. A closer examination also proves that Finland does not fit into the Nordic Media Welfare State model either, despite a long, shared history and cultural ties.
Karakteristik Masyarakat Abad 21
Authors: Reni Nurhayati  , Sofyan Iskandar  , Dede Trie Kurniawan
Published: February 2023

Abad ke-21 dianggap sebagai abad pengetahuan, abad ekonomi berbasis pengetahuan, abad teknologi berita, globalisasi, revolusi industri 4.0, serta sebagainya. di abad ini, terjadi perubahan yang sangat cepat serta sulit diprediksi dalam segala aspek kehidupan baik bidang ekonomi, transportasi, teknologi, komunikasi, info, serta lain – lain. Industri 4.0 pertama kali diperkenalkan pada Hannover Fair 2011 yang ditandai revolusi digital. Industry 4.0 adalah tren terbaru dari teknologi yang sedemikian rupa canggihnya, yang berpengaruh besar terhadap proses produksi pada sektor manufaktur. Penelitian ini menggunakan pendekatan deskriptif kualitatif, dimana pendekatan ini merupakan penelitian yang lebih menekankan pada pengamatan fenomena dan memerlukan insting yang tajam dari peneliti. Salah satu hasil dari teknologi adalah gadget. Gadget merupakan salah satu sarana komunikasi yang setiap masyarakat tidak bisa lepas dari alat komunikasi ini. Gadget merupakan telepon genggam atau telepon seluler (ponsel) atau handphone (HP). Gadget berupa HP, merupakan alat komunikasi yang paling sederhana, yang bisa digunakan oleh setiap orang. Dalam kehidupan sosial, gadget sangat berpengaruh baik terhadap perilaku maupun terhadap interaksi sosial. Gadget memiliki dampak positif dan negatif.
Solitary Rectal Ulcer Syndrome: An Unusual Cause of Per Rectal Bleeding in Children
Authors: Fathema Kaniz , Benzamin Md , Sayeed Maimuna , Nahid Khan Lamia
Published: February 2023

Solitary rectal ulcer syndrome (SRUS) is a relatively uncommon but troublesome chronic benign disorder more in young adults and less in children. It is usually presented as rectal bleeding, constipation, copious mucous discharge, prolonged excessive straining, tenesmus, lower abdominal pain, localized pain in the perineal area, feeling of incomplete defecation and rarely rectal prolapse.The underlying etiology is not well known. It is diagnosed based on symptoms and endoscopic and histological findings.
J Enam Med Col 2021; 11(1): 47-51
Konstruksi Internalisasi Perubahan Budaya Pernikahan Melalui Media Sebagai Pertarungan Modal Sosial Kelas Ekonomi Menengah
Authors: Koesanto Stefani Made Ayu Artharini
Published: February 2023

The purposed of this research is to find how the construction of wedding cultural change phenomenon of middle low economic class society in Palangkaraya internalized through media. This research applies Pierre Bourdieu's reproduction of culture, Berger-Luckman’s construction of social reality, Veblen's emulation and global media concept as the framework. The Paradigm used in this research is constructionism and qualitative research which held in Palangkaraya. Depth interview and observation are used as data collection technique. This research has succeeded to explain the connection between social construction of reality on marriage and social struggle in the field of wedding with the influence of mass media in the wedding cultural change phenomenon for middle low economic class in Palangkaraya.
Filosofi Hindu Narasi Banalisme Filosofi Hindu Dalam Konten Wonderland Indonesia 2 Karya Alffy Rev
Authors: Kurniasari Ni Gusti Ayu Ketut , Toni Ahmad
Published: February 2023

This study raises the topic of Hindu pghilosophy contained in the Wonderland Indonesia 2 video by Alffy Rev. The method is narrative analysis with secondary text data in the form of videos on the youtube channel. The results show the: the prologue narration describes the historical symbol constructs the were excavated in the garuda mythology, the Majapahit symbol and depict the under or dark culture of the dragon and the light culture of the garuda. The content narration describes the relationship between the historicity of the mythological wolrd of garuda, Majapahit and national values combined with traditionl art of folk songs and supporting costume elements between various dimensions of banality. The element of banality constructed by the text produser describes a narrative about the integration and unification of the dimensions of nature, creation manajement and idependence after destruction in the trisula philosophy wich is integrated in Hindu culture and teachings. In the final naarative, it is described how the relationship between history and the younger generation of Indonesia is as a form of reconstruction of the values struggle and multiculturalism as a reading of the history of mythology, the history of Majapahit, the history of the independence of the Indonesian nation.
Coffee Quality Prediction with Light Gradient Boosting Machine Algorithm Through Data Science Approach
Authors: Putra Adya Zizwan , Chalvin Chalvin , Nurhadi Achmad , Tambun Andro Eriel , Defha Syahmir
Published: February 2023

In increasing sales by increasing consumer satisfaction with the quality of coffee sold. A way is needed to make it easier to predict the determination of quality coffee so as to increase the efficiency of the coffee sorting process which does not take a long time and can increase the productivity of companies that have competitiveness. Several developments have been made to improve the performance of the algorithm which has the potential to produce good quality predictions. Import Copy Data into a format that can be processed to a later stage or with a Machine Learning algorithm. Copy data that can be processed is then modified in such a way as to ensure that the data is suitable for use in Data Science or Machine Learning processes. By using coffee data specifications from the plantation to the coffee beans produced, it is expected that coffee quality can be predicted quickly without the need for manual calculations or analysis by humans. The working procedures for selecting the quality of coffee beans are coffee import data, coffee data processing, split test-train coffee data, light gradient enhancement machine, yield prediction, and Performance Prediction Evaluation. The amount of data used is 1,339 data. The dependent variable in this data is Coffee Quality while the rest will be cleaned and processed to serve as an independent variable. The accuracy rate of the algorithm in predicting coffee quality is 72%.
Acesso de primeiro contato avaliado pelo PCATOOL versão profissionais em cenário pré-pandemia por COVID-19 de Alfenas, Sul de Minas Gerais
Authors: Romero Ray Braga , Jorge Lethícia Fernandes , Pereira Ana Carolina Alcântara , Silva Poliana Souza da , Rezende Filho Marcelo Romêro , Loyola Edilaine Assunção Caetano de , Silva Roberta Bessa Veloso , Silvério Alessandra Cristina Pupin
Published: February 2023

A Estratégia Saúde da Família (ESF) é indispensável para o Sistema Único de Saúde (SUS), pois aperfeiçoa as diretrizes da atenção básica e amplia sua resolutividade. À vista disso, o questionário PCATool versão Profissionais se faz um instrumento essencial ao mensurar o Acesso de Primeiro Contato – Acessibilidade. Esse quesito, quando dispõe de utilização e acessibilidade adequada e age em tempo oportuno, faz da atenção primária a porta de entrada para os demais níveis de atenção em saúde. Assim, o objetivo desta pesquisa é a avaliação diagnóstica da atenção primária à saúde na rede de ESF da cidade de Alfenas, Minas Gerais, a partir da aplicação do questionário PCATool-Brasil Versão Profissionais. Aprovada pelo comitê de ética com número 814.099, a pesquisa foi realizada por meio da aplicação, de forma impressa, do questionário PCAtool-Brasil Versão Profissionais a 117 funcionários da ESF da cidade. Os dados levantados foram organizados em uma tabela no software Excel e, posteriormente, calculou-se os scores seguindo o Manual PCAtool-Brasil Versão Profissionais, sendo a média a principal medida de definição dos dados. Com isso, mensurou-se a qualidade do acesso de primeiro contato e obteve-se resultados negativos (<2) em unidades de saúde ITP, UNS e BE. As demais unidades se encontram com média geral de 2,20, próxima a valores negativos. Conclui-se que as unidades de saúde de Alfenas necessitam de atenção no quesito acessibilidade.
Hyödyllistä tietoa yhteiselle kansalle
Authors: Toropainen Tanja
Published: February 2023

Turun akatemian matematiikan professori Nils Hasselbom (1690–1764) pyrki tarjoamaan toimittamissaan almanakoissa suomenkieliselle yleisölle hyödyllistä valistuskirjallisuutta. Hasselbom oli edelläkävijä, sillä käytännönläheiset, yleishyödylliset suomenkieliset tekstit alkoivat yleistyä vasta 1700-luvun jälkipuoliskolla ja silloinkin pitkälti almanakoissa julkaistujen maataloutta ja terveydenhoitoa käsittelevien ohjetekstien ansiosta.
Promootioiden historiaa Turussa
Authors: Artukka Topi
Published: February 2023

Yliopistojen järjestämien promootioiden historia ulottuu Euroopassa pitkälle keskiajalle saakka, sillä jo 1200-luvun Pariisissa ja Bolognassa väitelleitä kandidaatteja vihittiin maistereiksi. Eurooppalaisista yliopistoista oppiarvojen myöntöjuhla levisi Ruotsiin, jossa seremonia otettiin käyttöön ensin Uppsalan yliopistossa vuonna 1600 ja sitten Turun akatemiassa vuonna 1643. Promootiot olivat yliopiston tärkein yhteisöllinen juhla, jonka avulla paitsi kiinnitettiin oppineet osaksi akateemista yhteisöä, myös rakennettiin sisäistä hierarkiaa ja symboliikkaa.
History of Ceremonial Conferments in Turku
Authors: Artukka Topi , Ratia Mari
Published: February 2023

The history of ceremonial conferments organised by European universities goes back to the Middle Ages, as bachelors were conferred as masters in Paris and Bologna already in the 13th century. From the European universities, the tradition of conferring academic degrees spread to Sweden, where the ceremony was first organised at the Uppsala University in 1600 and at the Royal Academy of Turku in 1643. At that time, Finland and Turku were part of the Swedish kingdom and the Royal Academy of Turku, founded in 1640, was the first university in Finland. This university was situated in Turku until the great fire of 1827, after which the university was moved to Helsinki, the new capital of Finland. Ceremonial conferments have been an important celebration for the community, as not only does the ceremony confer scholars as part of the academic community, but it also builds internal hierarchy and symbolism.
Pinealectomy increases and exogenous melatonin decreases leptin production in rat anterior pituitary cells: an immunohistochemical study.
Authors: Kus I , Sarsilmaz M , Colakoglu N , Kukner A , Ozen OA , Yilmaz B , Kelestimur H
Published: February 2023

Melatonin, the main hormone of the pineal gland, informs the body about the environmental light and darkness regimen, which in turn contributes to the photoperiodic adaptation of several physiological functions. Leptin, the hormone secreted mainly by adipocytes and some other tissues including the pituitary, informs the brain about the mass of adipose tissue, which plays an important role in energy homeostasis. Melatonin has been shown to decrease circulating leptin levels. It is currently not known whether melatonin has an effect on leptin synthesis in the pituitary. The aim of this study was to immunohistochemically examine the effects of pinealectomy and administration of melatonin on leptin production in the rat anterior pituitary. The pituitary samples obtained from 18 male Wistar rats including sham-pinealectomized, pinealectomized and melatonin-injected pinealectomized groups were immunohistochemically evaluated. Immunostaining of leptin was moderate (3+) in sham-pinealectomized rats, heavy (5+) in pinealectomized rats and low (1+) in melatonin-treated pinealectomized rats, respectively. The present results indicate that pinealectomy induces leptin secretion in anterior pituitary cells, and this increase of leptin synthesis can be prevented by administration of melatonin. Thus, melatonin seems to have both physiological and pharmacological effects on leptin production in the anterior pituitary of male rats.
Effects of sizofiran on endotoxin-enhanced cold ischemia-reperfusion injury of the rat liver.
Authors: Kukan M , Szatmáry Z , Lutterová M , Kuba D , Vajdová K , Horecký J
Published: February 2023

Kupffer cells (KC), resident macrophages of the liver, have been strongly implicated in lipopolysaccharide (LPS)-induced liver graft injury. However, our recent study showed that sizofiran (schizophyllan glucan) (SPG), which activates KC, did not influence cold ischemia-reperfusion liver injury of LPS-exposed rats. Here we investigated some mechanisms by which SPG does not aggravate LPS-enhanced cold ischemia-reperfusion rat liver injury. Control and SPG-treated rats were exposed to LPS for 2 h prior to hepatectomy. The livers were cold-preserved in University of Wisconsin solution followed by reperfusion with Krebs-Henseleit buffer. We found that SPG dramatically inhibited LPS-induced increases of tumor necrosis factor-α (TNF-α) in the plasma and bile in vivo. Moreover, LPS-induced TNF- release into the washout solution after cold ischemia was also abrogated by SPG pretreatment. However, SPG increased TNF-α release into the perfusate after reperfusion. On the other hand, SPG completely abolished expression of c-myc protooncogene, which is known to sensitize cells to TNF-α cytotoxicity. In conclusion, inhibition of both TNF-α release after LPS challenge and c-myc expression may explain why activation of KC with SPG does not aggravate endotoxin-enhanced cold ischemia-reperfusion liver injury.
Exploring Changes in Female College Students' Perception of Online Classes in the COVID-19 Era: Focusing on the Use of Text Mining
Authors:   The Korean Society of Culture and Convergence, Park Insim , Ahn Miri , Choi Eunjung
Published: February 2023

COVID-19 has changed the paradigm of everyday life to online and has brought about many changes in university education. This study aims to identify changes in student perception of online classes using big data analysis. For this purpose, data from March 2020 to June 2021 were collected from the ‘Everytime’ community site, using Python programming language. Then text mining, namely, Keyword frequency analysis, network analysis, and sentiment analysis were conducted. The implications derived from the findings suggested some ideas worth considering in improving online classes at university.
A Study on the Current Situation and Improvement of Extracurriculum in College Basic General Mathematics
Authors:   The Korean Society of Culture and Convergence, Lee Jungkyung
Published: February 2023

The purpose of this study is to improve how basic general mathematics extracurricular programs should be managed based on liberal arts education curriculum by comparing and analyzing the operation status according to the types of the liberal arts extracurricular programs operated by the university’s liberal arts education institution. It is necessary to establish a basic mathematics center inside the university to support and manage mathematics education for students of all disciplines. In this regard, professional professors in charge of mathematics extracurricular programs should be assigned, supported, and operated. In addition, to make students aware of the concept of the extracurricular program and the importance of its role, an active public relations system is required. This study will provide data in developing extracurricular programs related to the basic general mathematics and suggest directions for improvement of the basic general mathematics extracurricular programs.
A Study on the Effect of Chinese Generation Z’s Satisfaction with Web Novels on Psychological Well-being: Based on the Expectancy-Value Theory
Authors:   The Korean Society of Culture and Convergence, Li Ge , Kim Sunyoung
Published: February 2023

Recently, with the market size and number of subscribers of Web Novels increasing in China, the growth trend is remarkable, mainly centered on Generation Z. Therefore, we applied Expectancy -Value Theory to empirically identify the relationship between seeking satisfaction and acquisition satisfaction of Chinese generation Z users who use Web Novels on their psychological stability. As a result, we found that the higher the expectation for the four factors of entertainment, sociality, quality excellence, and ease of use, the higher the correlation with satisfaction after use. In addition, while the results showed that overall satisfaction in pursuit showed a larger average value than satisfaction in acquisition, it was found that the psychological stability of Chinese generation Z increased when the acquisition satisfaction for entertainment, ease of use, variety, and quality excellence of Web Novel contents increased. In particular, the entertainment factor had the greatest influence on psychological stability, and it can be interpreted that Chinese generation Z read Web Novels for fun, vicarious satisfaction, and amusement that soothes ordinary daily life, and through this, they gain psychological stability.
Analysis of Perception Differences on Public Service Motivation by Function of Police Affairs: Focusing on the Autonomous Police System
Authors:   The Korean Society of Culture and Convergence, Park Hunkook
Published: February 2023

This study analyzes the differences in perception of public service motivation among police officials in national police, investigative police, and autonomous police work classified by police service function, and makes strategic proposals for police organizations to derive results and increase public service motivation. As a result of the analysis, there was a difference in perception of public service motivation of police officials in Korea for each office function, and the commitment to public interest was the most different. It was found that the internalization of an individual's public service motivation could be strengthened or weakened by various environmental factors and functions of police affairs, even though it was a motivation formed for a long time. Therefore, it will be necessary to seek a change in systematic education and management strategies for the public service motivation of police officials.
The Effect of Participation in Watching Medical Dramas on the Viewer's View of Life and Death and Organ Donation Intention: Focusing on the Mediating Effect of Cognitive Dissonance Reduction Behavior
Authors:   The Korean Society of Culture and Convergence, Cheng Suyang , Jun Jongwoo
Published: February 2023

This study uses viewing involvement as a leading variable from the perspective of communication, and attempts to explore the effect of medical dramas on individual life and death and organ donation intention using cognitive dissonance theory. Specifically, this study conducted a questionnaire survey on viewers who have watched Season 2 of “Hospital Playlist.” For data analysis, a multivariable regression analysis was conducted to verify the indirect effect using Hayes' Proxis Macro Model 4. As a result of the study, it showed the complete mediating effect of cognitive dissonance reduction behavior in the influence of emotional viewing involvement, personal view, and organ donation intention, and the partial mediating effect of cognitive dissonance reduction behavior in the influence of cognitive viewing involvement, personal view, and organ donation intention was significant. Through this study, it is possible to clarify the role of viewing involvement and cognitive dissonance in promoting public health behavior awareness. Meanwhile, it was verified that medical dramas will have a positive effect on the formation of an organ donation atmosphere in society as a whole in the future.
A Study on the Effects of Track System-based Convergence Education Support on University Student’s Creative Confluence Competency
Authors:   The Korean Society of Culture and Convergence, Baek Sanghyon , park Jeongeun
Published: February 2023

The purpose of this study was to understand the effects of track system-based convergence education support on university students’ creativity and interdisciplinary abilities. Among the students of H university, which operates the track system, 1,229 students who participated in the core competencies assessment in the second semester of 2021 were the subject of the study. For analysis, t-test, ANOVA and multiple regression analysis were conducted. Factors were explored in creative confluence competency as dependent variables, and the results are as follows. First, there were significant differences in creative confluence competency according to participation on convergence education. Second, GPA, capstone design course attendance, creativity convergence based extracurricular activities, satisfaction of Sangsang Park, satisfaction of major courses were statistically significant in explaining creative confluence competency. Based on the results, suggestions and policies were discussed, along with limitations.
Metaverse-based Language Education Platform Development and User Experience Evaluation
Authors:   The Korean Society of Culture and Convergence, Bang Mihyang
Published: February 2023

The application of the metaverse to language education is becoming more active due to the growth of the language education market and language learning effects via AR and VR technology. This study aims to evaluate user experience after designing an English education platform for elementary school students, namely Meta-English, in the metaverse environment and developing a prototype. To this end, the Meta-English platform is designed based on the strategies derived from the analysis of the user experience of language education platforms. After developing ‘Word World‘ as a prototype in Meta-English and the evaluating user experience, a new possibility for establishing a metaverse-based language learning platform is presented. In the evaluation result, 51 users rated ’Word World‘ positively with an average score of 4.05, and a slight difference in the evaluation between groups. It is hoped that this study will be a professional and practical help when developing metaverse-based language education content in the future.
STEMI VE NSTEMI OLGULARINDA COVID-19 KORKUSU VE TEDAVİNİN ERTELENMESİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: KALKAN UĞURLU Yasemin , KUCUK ALEMDAR Dilek , ÇALGIN Ülkü , KAYA Ahmet
Published: February 2023

Bu çalışma içinde bulunduğumuz COVID-19 pandemisinde Miyokard Enfarktüsü (STEMI-NSTEMI) geçiren bireylerin ilk semptomların başlaması ile hastaneye başvurusu arasında geçen süre ile COVID-19 korkusu arasındaki ilişkiyi değerlendirmek amacıyla gerçekleştirilmiştir. Tanımlayıcı türdeki bu çalışma 10 Aralık 2020 ile ülkemizde ilk vakanın saptanmasının yıldönümü olan 10 Mart 2021 tarihi arasında, bir eğitim ve araştırma hastanesine başvuran, STEMI ve NSTEMI tanı kriterlerine uyan ve primer perkütan koroner girişim (PPKG) yapılan 31 hasta ile yapıldı. Bir yıl önce aynı zaman aralığında PPKG yapılan, aynı tanıya sahip 31 hasta kontrol grubu olarak çalışmaya dahil edildi. COVID-19 pandemisi öncesinde hastaların ilk semptom ile hastaneye başvuru arasında geçen süre 33.95±61.64 (median 2 saat) saat iken, pandemi döneminde bu sürenin 264±586.064 (median 12 saat) saat olduğu ve aralarındaki farkın anlamlı olduğu belirlendi. Yapılan çoklu regresyon analizine göre COVID-19 döneminde ertelenen tedavi ile hastaların COVID-19 korkusu arasında bir ilişki olmadığı saptandı. Hastaların COVID-19 korkusuna karşı farkındalık geliştirebilecekleri varsayılsa da yüksek kardiyovasküler hastalık riskine sahip hastalara yardımcı olmak için önlemler alınmalı ve akut olaylar durumunda hastaneye zamanında erişim sağlamaları için rehberlik edilmelidir.
Importance of the female reproductive tract microbiome and its relationship with the uterine environment for health and productivity in cattle: A review
Authors: Ault-Seay Taylor B. , Moorey Sarah E. , Mathew Daniel J. , Schrick F. Neal , Pohler Ky G. , McLean Kyle J. , Myer Phillip R.
Published: February 2023

Once thought to be sterile, the reproductive tract microbiome has been characterized due to the transition from culture-dependent identification of bacteria to culture-independent sequencing methods. The urogenital microbiome was first identified in women through the Human Microbiome Project, which led to research in other species such as the bovine. Previous research focused on uterine bacteria associated with postpartum disease, but next generation sequencing methods identified a normal, healthy bacterial community of the reproductive tract of cows and heifers. Bacterial communities are now understood to differ between the uterus and vagina, and throughout the estrous cycle with changes in hormone dominance. In a healthy state, the bacterial communities largely interact with the uterine environment by assisting in maintaining the proper pH, providing and utilizing nutrients and metabolites, and influencing the immunological responses of the reproductive tract. If the bacterial communities become unbalanced due to an increase in potentially pathogenic bacteria, the health and fertility of the host may be affected. Although the presence of a reproductive tract microbiome has become widely accepted, the existence of a placental microbiome and in utero colonization of the fetus is still a popular debate due to conflicting study results. Currently, researchers are evaluating methods to manipulate the reproductive bacterial communities, such as diet changes and utilizing probiotics, to improve reproductive outcomes. The following review discusses the current understanding of the reproductive tract microbiome, how it differs between humans and cattle, and its relationship with the uterine environment.
Relative instability ratios of bone wall defects in trochanteric hip fractures: A finite element analysis
Authors: Yang Ao-Lei , Mao Wei , Chang Shi-Min , Dong You-Hai
Published: February 2023

Background: For decades, medial and lateral wall fragments of trochanteric hip fractures were considered two pivotal factors that could influence the stability of postoperative femur-implant complex. However, most studies seemed to misunderstand the concept of the posteromedial fragment and equated it with the medial wall, which overlooked vital roles of the anteromedial wall. Roles of the posterior coronal bone fragment were also highlighted in some research. However, influences of the bone walls above the trochanteric fracture instability are yet to be investigated and quantified by means of finite element analysis.

Methods: Eight trochanteric fracture fixation models with different wall defects were constructed. Outcome indicators were the von Mises stress of the implant models, the maximum/minimum principal strain, the risky tensile/compressive volume and the volume ratios of the bone models, the femoral head vertex displacement, and the fracture surface gap. Based on these indicator values, the relative instability ratios were computed.

Results: Outcome indicators, absolute values, and nephograms of all models showed the same upward and concentrating trends with exerted hip contact loads shifting from static walking to dynamic climbing. Similarly, these indicators also exhibited the same trends when the eight models were solved in sequence. Moreover, the relative instability ratio of the medial wall (100%), particularly the anteromedial part (78.7%), was higher than the figure for the lateral wall (36.6%).

Conclusion: The anteromedial wall played relatively pivotal stabilizing roles in trochanteric hip fractures compared with the posteromedial wall and the lateral wall, which indicated that orthopedic surgeons should attach more importance to the anteromedial cortex support in an operating theatre.
Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
Authors: Zhang Fan , Yan Yuanliang , Cai Yuan , Liang Qiuju , Liu Yuanhong , Peng Bi , Xu Zhijie , Liu Wei
Published: February 2023

Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in vitro and in vivo studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies.
OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression
Authors: Tanushi Xhaferr , Pinna Guillaume , Vandamme Marie , Siberchicot Capucine , D’Augustin Ostiane , Di Guilmi Anne-Marie , Radicella J. Pablo , Castaing Bertrand , Smith Rebecca , Huet Sebastien , Leteurtre François , Campalans Anna
Published: February 2023

One of the most abundant DNA lesions induced by Reactive oxygen species (ROS) is 8-oxoG, a highly mutagenic lesion that compromises genetic instability when not efficiently repaired. 8-oxoG is specifically recognized by the DNA-glycosylase OGG1 that excises the base and initiates the Base Excision Repair pathway (BER). Furthermore, OGG1 has not only a major role in DNA repair but it is also involved in transcriptional regulation. Cancer cells are particularly exposed to ROS, thus challenging their capacity to process oxidative DNA damage has been proposed as a promising therapeutic strategy for cancer treatment. Two competitive inhibitors of OGG1 (OGG1i) have been identified, TH5487 and SU0268, which bind to the OGG1 catalytic pocket preventing its fixation to the DNA. Early studies with these inhibitors show an enhanced cellular sensitivity to cytotoxic drugs and a reduction in the inflammatory response. Our study uncovers two unreported off-targets effects of these OGG1i that are independent of OGG1. In vitro and in cellulo approaches have unveiled that OGG1i TH5487 and SU0268, despite an unrelated molecular structure, are able to inhibit some members of the ABC family transporters, in particular ABC B1 (MDR1) and ABC G2 (BCRP). The inhibition of these efflux pumps by OGG1 inhibitors results in a higher intra-cellular accumulation of various fluorescent probes and drugs, and largely contributes to the enhanced cytotoxicity observed when the inhibitors are combined with cytotoxic agents. Furthermore, we found that SU0268 has an OGG1-independent anti-mitotic activity—by interfering with metaphase completion—resulting in a high cellular toxicity. These two off-target activities are observed at concentrations of OGG1i that are normally used for in vivo studies. It is thus critical to consider these previously unreported non-specific effects when interpreting studies using TH5487 and SU0268 in the context of OGG1 inhibition. Additionally, our work highlights the persistent need for new specific inhibitors of the enzymatic activity of OGG1.
Environmentally benign silver bio-nanomaterials as potent antioxidant, antibacterial, and antidiabetic agents: Green synthesis using Salacia oblonga root extract
Authors: Dugganaboyana Guru Kumar , Kumar Mukunda Chethan , Jain Anisha , Kantharaju Raghavendra Mandya , Nithya Rani R. , Ninganna Divya , Ahalliya Rathi Muthaiyan , Shati Ali A. , Alfaifi Mohammad Y. , Elbehairi Serag Eldin I. , Silina Ekaterina , Stupin Victor , Velliyur Kanniappan Gopalakrishnan , Achar Raghu Ram , Shivamallu Chandan , Kollur Shiva Prasad
Published: February 2023

Introduction: The use of plant extracts in the green synthesis of metallic nanoparticles is one of the simplest, most practical, economical, and ecologically friendly methods for avoiding the use of toxic chemicals.

Method: Silver nanoparticles (AgNPs) were synthesized, employing a high-efficiency, non- toxic, cost-effective, green, and simple technique that included the use of Salacia oblonga root extract (SOR) as a capping agent compared to synthetic nanoparticles. The use of S. oblonga can be seen in traditional medicines for treating diabetes, obesity, rheumatism, gonorrhea, asthma, and hyperglycemia. The objectives of the current study were to green synthesize S. oblonga root extract silver nanoparticles (SOR-AgNPs), characterize them, and study their antioxidant, antibacterial, and antidiabetic activities.

Result: The shape of SOR-AgNPs was spherical, at less than 99.8 nm in size, and exhibited a crystalline peak at XRD. The green synthesized SOR-AgNPs showed significant antioxidant properties like DPPH (80.64 μg/mL), reducing power capacity (81.09 ± SEM μg/mL), nitric oxide (96.58 μg/mL), and hydroxyl (58.38 μg/mL) radical scavenging activities. The MIC of SOR-AgNPs was lower in gram-positive bacteria. The SOR-AgNPs have displayed efficient inhibitory activity against α-amylase, with an EC50 of 58.38 μg/mL. Analysis of capping protein around the SOR-AgNPs showed a molecular weight of 30 kDa.

Discussion: These SOR-AgNPs could be used as antibacterial and antidiabetic drugs in the future as it is cheap, non-toxic, and environmentally friendly. Bio-fabricated AgNPs had a significant impact on bacterial strains and could be used as a starting point for future antibacterial drug development.
Cyprinid herpesvirus 2 infection changes microbiota and metabolites in the gibel carp (Carassius auratus gibelio) midgut
Authors: Chen Peng , Zhang Mingming , Zhang Yichan , Li Jun , Wan Xihe , Lv Tingli , Chen Yiyue , Zhao Zhigang , Ma Zhihao , Zhu Zhu , Chen Lihua , Li Zhen , Wang Zisheng , Qiao Guo
Published: February 2023

Cyprinid herpesvirus 2 (CyHV-2) infects gibel carp (Carassius auratus gibelio) and causes severe losses. Microbiota in animal guts involves nutrition intake, development, immunity, and disease resistance. However, the relationship between gibel carp gut microbiota and CyHV-2 infection is not well known. Herein, we analyzed the gut microbiota composition and metabolite profiles in CyHV-2-infected and -uninfected fish using high-throughput sequencing and gas chromatography/mass spectrometry. Results showed that CyHV-2 infection significantly changed gut microbiota and metabolite profiles (p < 0.05). High-throughput sequencing demonstrated that the relative abundance of Aeromonas in the midgut increased dramatically while Cetobacterium decreased. Time-course analysis showed that the number of Aeromonas in the midgut of infected fish increased more than 1,000 times within 5 days post infection. Metabolome analysis illustrated that CyHV-2 infection significantly altered 24 metabolites in the midgut of gibel carp, annotating to the anomaly of digestion and metabolisms of amino acids, carbohydrates, and lipids, such as tryptophan (Trp) metabolism. The Mantel test demonstrated that gut microbiota and metabolite profiles were well related (r = 0.89). Furthermore, Trp metabolism responded to CyHV-2 infection closely was taken as one example to prove the correlation among CyHV-2 infection, metabolites and microbiota in the midgut, and host immunity. Results showed that modulating Trp metabolism could affect the relative abundance of Aeromonas in the midgut of fish, transcription of antiviral cytokines, and CyHV-2 infection. Therefore, we can conclude that CyHV-2 infection significantly perturbed the gut microbiome, disrupted its’ metabolic functions, and caused the proliferation of the opportunistic pathogen Aeromonas. This study also suggests that modulation of the gut microbiome will open a therapeutic opportunity to control CyHV-2 infection in gibel carp.
Association of serum N-terminal pro-brain natriuretic peptide levels with survival and renal outcomes among elderly patients with acute kidney injury in chronic heart failure
Authors: Hou Jiebin , Zhang Xin , Wu Zhen , Liu Yang , Zhang Yabin , Zhao Jiahui , Wang Xiaohua , Chen Hongyu , Yang Guang , Ma Qiang , Cheng Qingli , Ao Qiangguo
Published: February 2023

Background

Elderly patients exhibit a higher incidence of chronic heart failure (CHF). Patients with CHF can develop acute kidney injury (AKI) during follow-up, which can result in poor prognosis. This relationship between kidney dysfunction and levels of N-terminal pro-brain natriuretic peptides (NT-proBNP), with regard to prognosis, is complicated and has rarely been analyzed in elderly patients with CHF.

Method

We conducted a retrospective cohort study involving patients with a CHF history aged ≥ 65 years, who experienced an episode of AKI. Kaplan–Meier curves and Cox or logistic proportional hazards regression models were used to evaluate the association between serum NT-proBNP concentrations and mortality or renal recovery by day 90.

Results

A total of 1,160 eligible patients with AKI were available for the study. Of this sample, 41.5% of patients died within 90 days of the onset of AKI. Patients with a decreased change in NT-proBNP accompanying the episode of AKI had a lower risk (adjusted OR = 0.56, 95% CI = 0.34−0.91) of more severe AKI (stage 2 and 3 vs. stage 1). The more severe AKI were associated with higher mortality and non-recovery of renal function in elderly patients with CHF, independent of NT-proBNP levels. Elevated levels of baseline lnNT-proBNP (adjusted HR = 1.27, 95% CI = 1.17−1.38) predicted mortality in elderly patients with CHF within 90 days of AKI onset. Patients with a decrease in NT-proBNP accompanying AKI had a lower risk of mortality (adjusted HR = 0.62, 95% CI = 0.48−0.79). However, a decrease in NT-proBNP is a risk factor (adjusted OR = 1.59, 95% CI = 1.02−2.48) for the non-recovery of renal function following AKI–especially in elderly survivors with low baseline NT-proBNP levels.

Conclusion

A decreased change in NT-proBNP maybe protective for elderly patients with CHF by improving survival outcomes and preventing severe AKI. However, an excessive decrease in NT-proBNP is a risk factor for the non-recovery of renal function following AKI. Avoiding excessive changes in NT-proBNP may be protective for survival and renal injury prognosis.
An adult female patient with single atrium and single ventricle undergoing appendectomy: A case report
Authors: Wu Yu , Cai Zenghua , Cheng Jianzheng , Zhang Bo , Wang Guoji , Li Wei , Zhang Zaiwang
Published: February 2023

Appendicitis is one of the common diseases, and appendectomy is one of the most commonly performed procedures. Single atrium and single ventricle are rare heart diseases, and very few patients survive to adulthood. We report a patient with single atrial and single ventricles undergoing appendectomy with transverse abdominis plane block and dexmedetomidine sedation anesthesia with smooth postoperative appendectomy.
Displacement prediction of open-pit mine slope based on SSA-ELM
Authors: Li Bo , Qiu Junbo
Published: February 2023

Mine geological disaster is a complex non-linear system. The traditional prediction model has the disadvantages of low prediction accuracy and poor reliability. In order to solve this problem, the open-pit mine slope displacement is taken as the research object. Based on a new algorithm extreme learning machine (ELM), the new intelligent algorithm sparrow search algorithm (SSA) are introduced to determine the weights and thresholds of the input layer and hidden layer of ELM. The open-pit mine slope displacement prediction model of improved ELM is constructed and applied to an engineering example. The results show that the root mean square error of SSA-ELM model is only a quarter of that of BP model, which is 50% higher than that of GM (1,1) and ELM models. The correlation coefficient of the prediction results of the SSA-ELM model is 0.983, and the accuracy is better than that of the traditional model. The single ELM model and the PSO-ELM model show that the SSA algorithm has better improvement effect. The SSA model has good comprehensive performance and high prediction accuracy. It is feasible to apply it to the prediction of slope displacement in open-pit mines.
One-degree resolution mascon solution over Antarctic derived from GRACE Level-2 data
Authors: Wang Wei , Shen Yunzhong , Chen Qiujie , Chen Tianyi
Published: February 2023

The mass loss of the Antarctic Ice Sheet (AIS) is an important contributor to global sea-level rise in response to the warming ocean and atmospheric temperatures as well as the changes in current systems and precipitation patterns. In this study, a regional mascon method is developed to squeeze more mass change signals, in which the pseudo-observations of the geopotential are generated from the unfiltered GRACE Level-2 data whereas the regularization matrix is constructed with the prior information derived from filtered GRACE Level-2 data. A series of mascon solutions with 1°×1° equal-area resolution over AIS is derived from the updated Tongji-Grace2018 model spanning April 2002 to December 2016. Compared to the filtering results from P4M6 decorrelation and 100 km Gaussian filtering, our mascon solutions can effectively suppress the strips, improve the spatial resolution over AIS, and get a stronger signal with an improvement of 116.86% in the Antarctic Peninsula Ice Sheet (APIS), and more coincide with the features of glaciers and ice streams, such as the most striking ice mass loss in Totten, Getz, Thwaites and Pine Island, and the ice mass gain in Kamb Ice Stream. During the period from 2002 to 2016, the mass change rates from our mascon solution are −103.6 ± 5.6 Gt/yr, 63.0 ± 4.3 Gt/yr, −143.3 ± 4.9 Gt/yr and −23.29 ± 1.2 Gt/yr in AIS, East AIS, West AIS, and APIS, respectively. The mass change signals at the basin scale are with even more distinguishing features, with the highest mass gain rates of 18.03 ± 1.88 Gt/yr and 14.55 ± 0.60 Gt/yr at Basin 7 and Basin 18, and the highest mass loss rates of −58.57 ± 2.48 Gt/yr and −44.12 ± 2.27 Gt/yr at Basin 21 and Basin 22. Relative to the cumulated surface mass balance from the regional atmospheric climate model, the correlation coefficients of our mascon solutions are 0.91, 0.94, and 0.96 in East AIS, West AIS, and APIS.
Reconstructing long-term global satellite-based soil moisture data using deep learning method
Authors: Hu Yifan , Wang Guojie , Wei Xikun , Zhou Feihong , Kattel Giri , Amankwah Solomon Obiri Yeboah , Hagan Daniel Fiifi Tawia , Duan Zheng
Published: February 2023

Soil moisture is an essential component for the planetary balance between land surface water and energy. Obtaining long-term global soil moisture data is important for understanding the water cycle changes in the warming climate. To date several satellite soil moisture products are being developed with varying retrieval algorithms, however with considerable missing values. To resolve the data gaps, here we have constructed two global satellite soil moisture products, i.e., the CCI (Climate Change Initiative soil moisture, 1989–2021; CCIori hereafter) and the CM (Correlation Merging soil moisture, 2006–2019; CMori hereafter) products separately using a Convolutional Neural Network (CNN) with autoencoding approach, which considers soil moisture variability in both time and space. The reconstructed datasets, namely CCIrec and CMrec, are cross-evaluated with artificial missing values, and further againt in-situ observations from 12 networks including 485 stations globally, with multiple error metrics of correlation coefficients (R), bias, root mean square errors (RMSE) and unbiased root mean square error (ubRMSE) respectively. The cross-validation results show that the reconstructed missing values have high R (0.987 and 0.974, respectively) and low RMSE (0.015 and 0.032 m3/m3, respectively) with the original ones. The in-situ validation shows that the global mean R between CCIrec (CCIori) and in-situ observations is 0.590 (0.581), RMSE is 0.093 (0.093) m3/m3, ubRMSE is 0.059 (0.058) m3/m3, bias is 0.032 (0.037) m3/m3 respectively; CMrec (CMori) shows quite similar results. The added value of this study is to provide long-term gap-free satellite soil moisture products globally, which helps studies in the fields of hydrology, meteorology, ecology and climate sciences.
Risk factors of recurrent secondary hyperparathyroidism after adequate primary surgical treatment
Authors: Kuo Yu-Chi , Wang Shang-Yu , Hung Yu-Liang , Hsu Chih-Chieh , Kou Hao-Wei , Chen Ming-Yang , Tsai Chun-Yi , Chang Chih-Hsiang , Wang Yu-Chao , Hsu Jun-Te , Yeh Ta-Sen , Lee Wei-Chen , Yeh Chun-Nan
Published: February 2023

Background

Secondary hyperparathyroidism (SHPT) is a common condition in patients with end-stage renal disease (ESRD) who are on dialysis. Parathyroidectomy is a treatment for patients when medical therapy has failed. Recurrence may occur and is indicated for further surgery in the era of improved quality of care for ESRD patients.

Methods

We identified, 1060 patients undergoing parathyroidectomy from January, 2011 to June, 2020. After excluding patients without regular check-up at our institute, primary hyperparathyroidism, or malignancy, 504 patients were enrolled. Sixty-two patients (12.3%, 62/504) were then excluded due to persistent SHPT even after the first parathyroidectomy. We aimed to identify risk factors for recurrent SHPT after the first surgery.

Results

During the study period, 20% of patients who underwent parathyroidectomy at our institute (in, 2019) was due to recurrence after a previous parathyroidectomy. There were 442 patients eligible for analysis of recurrence after excluding patients with the persistent disease (n = 62). While 44 patients (9.95%) had recurrence, 398 patients did not. Significant risk factors for recurrent SHPT within 5 years after the first parathyroidectomy, including dialysis start time to first operation time < 3 years (p = 0.046), postoperative PTH >106.5 pg/mL (p < 0.001), and postoperative phosphorus> 5.9 mg/dL (p = 0.016), were identified by multivariate analysis.

Conclusions

The starting time of dialysis to first operation time < 3 years in the patients with dialysis, postoperative PTH> 106.5 pg/mL, and postoperative phosphorus> 5.9 mg/dL tended to have a higher risk for recurrent SHPT within 5 years after primary treatment.