bluuebunny/crossref_metadata_2025 huggingface dataset:
The perceived competence of paramedics to operate in different CBRNE incidents
Authors: Malinen Inka , Jama Timo , Tanninen Antti , Nordquist Hilla
Published: June 2024

Purpose

The aim of this study was to identify the perceived competence of Finnish paramedics to operate in different chemical, biological, radiological, nuclear, and explosive (CBRNE) incidents.

Design/methodology/approach

This was a descriptive cross-sectional survey study. The material was collected using a previously developed questionnaire, which was modified in accordance with the study aim. The target group was paramedics of the Päijät-Häme region of Finland (N = 166), whose role entailed active operational duties during the survey. Descriptive statistical methods were used.

Findings

Paramedics reported low levels of training related to CBRNE incidents, and most felt that more training was needed. Chemical and explosive-related incidents were regarded as more likely to occur than others. Additionally, paramedics with more work experience perceived themselves as having higher competence only in chemical and explosive-related incidents. Overall, paramedics perceived their CBRNE competence as low.

Originality/value

The perceived CBRNE competence of paramedics has not been studied sufficiently. Paramedics felt chemical and explosive related incidents were more likely to occur than others, and competence related to those two was also better perceived. This study showed that paramedics could benefit from more training to respond to CBRNE incidents to improve perceptions of their competence. However, the desired competence, actual competence, and appropriate training to respond to CBRNE incidents require further research.
A ripple effect in strengths use? Linking principals' use of personal strengths with teachers' strengths use and engagement
Authors: Lavy Shiri , Amoury-Naddaf Sahar
Published: June 2024

Purpose

Evidence has indicated plausible effects of employees' use of their personal strengths at work on their attitudes, performance and well-being. Although the use of personal strengths was also expected to benefit others in the organization, such effects have rarely been examined. Here we studied associations of principals’ use of their personal strengths with principals’ own engagement and with the strengths use and engagement of teachers under their supervision, anticipating that principals’ and teachers’ strengths use and engagement would be associated with students’ achievement.

Design/methodology/approach

We surveyed 92 Israeli principals and 474 of their teachers. Measures included self-reported strengths use and engagement of the participants’ and schools' student matriculation achievements.

Findings

The findings generally supported the hypotheses. HLM analyses indicated that principals' use of their personal strengths was associated with their own engagement and with teachers' strengths use and work engagement and teachers’ engagement (but not their strengths use) was associated with student achievement.

Research limitations/implications

These findings suggest the beneficial impact of principals' use of their personal strengths on teachers, with practical implications for fostering principals’ and teachers’ flourishing and creating and supporting humanizing schools, by building on principals’ and teachers’ strengths and fostering their use at work.

Originality/value

This is the first study about the potential effects of principals’ strengths use on their own engagement and on others in the school. The significant associations found propose a promising path forward for principals’ positive impact on teachers and students.
Consumers’ perception of distribution channel for the Malaysian microtakaful scheme: an exploratory study
Authors: Shari Wahidah , Mohamed Naim Asmadi , Isa Mohamad Yazid , Sofi Mohd Fikri , Muhamed Nurul Aini , Maamor Selamah , Ahmad Shahrul Nizam
Published: June 2024

Purpose

This paper aims to investigate consumers’ preferences regarding the distribution channels for subscription, contribution payment and compensation claims of microtakaful scheme in Malaysia.

Design/methodology/approach

Consumers’ preferences were explored through questionnaires and focus group discussions (FGD) conducted among the bottom 40% income classification households (B40) in five zones: northern, central, eastern, southern and Sabah and Sarawak.

Findings

Empirical findings from cross-tabulation analysis revealed that takaful company is the preferred distribution channel for purchasing protection plans and making compensation claims. However, the online platform is the favoured channel to make contribution payments. Further investigation through FGD suggested that the selection of a channel for subscription, contribution payment and compensation claim is influenced by consumer trust, cost-effectiveness and simplicity of procedure.

Research limitations/implications

Limitation is pertaining to only cross-tabulation analysis used in explaining the choice of distribution channel for microtakaful among B40 group. Thus, advanced analysis is required to strengthen the findings.

Practical implications

Findings of this study would help marketers and practitioners to formulate strategies to promote their microtakaful protection to enhance subscription among the low-income population.

Originality/value

Empirical findings offer academic contributions to the existing body of knowledge on microtakaful area as the primary data collected will eventually allow future researchers to explicate the contribution of the current study to understand the important of distribution channel for microtakaful from the perspective of subscribers and potential subscribers.
Implementing digitally enabled integrated healthcare
Authors: Kaye Rachelle , Arvanitis Theodoros N. , Lim Choi Keung Sarah N. , Kalra Dipak , Verdoy Berastegi Dolores
Published: June 2024

Purpose

The European funded project ADLIFE focuses on the application of digitally enabled integrated care for people with advanced chronic diseases. The implementation of the ADLIFE intervention required a robust practical tool that would be common to all pilot sites while allowing flexibility for local variations as well as the ability to adapt to unanticipated changes and problems.

Design/methodology/approach

The ADLIFE project combined the concepts of implementation research and formative evaluation with the standardized operating procedures (SOP) methodology. The ADLIFE project significantly modified the SOP approach and used it as a means to not only to define and organize the tasks that needed to be performed in preparing and implementing the ADLIFE intervention but also to create a deeper understanding of the unique challenges faced in each site, as well as a method for achieving a consensus.

Findings

The ADLIFE SOPs were developed by a dedicated working group, and they encompassed the preparatory phase leading up to implementation of the intervention. The SOP was also the basis for monitoring the implementation, and this created a structure for the dynamic ongoing tactical and even strategic changes necessitated by local diversity as well as many unanticipated changes.

Originality/value

The SOP methodology was useful in supporting the development of the ADLIFE SOP, which was a consensus-based approach to guide for managing the implementation process, both at project and local levels. It has supported continuous improvement and learning throughout the project. Both the process and the SOP produced by the process can be readily adapted and used in other similar projects.
After more than a hundred years of research on entrepreneurship, what about looking for H.E.R.?
Authors: Matricano Diego
Published: June 2024

Purpose

The purpose of this paper is to answer a well-known but always-current question: what is the focus of entrepreneurship research? Usually, scholars address their attention toward the boundaries of entrepreneurship, and question the possible overlaps with innovation, on the one hand, and management, on the other. Despite their relevance, achieved results are still uncertain and opaque. To overcome these limits, the present paper adopts a different approach and, instead of delimiting the boundaries, looks for the heart of entrepreneurship research – H.E.R.

Design/methodology/approach

This paper reviews entrepreneurship literature not as a whole, but according to four main strands of research, respectively dealing with the telos (the Greek word standing for the aims), psychological traits, the context and the network. The results are read and interpreted to intertwine them and look for H.E.R.

Findings

This paper achieves two main results. First, it is clarified that H.E.R. consists of the adoption of dynamic capabilities by entrepreneurs and their networks in an attempt to foresee the future; the effort to work on entrepreneurial opportunities to make them mature for stakeholders and the market, thus reducing the likeability bias; and the reference to a context characterized by unknown unknowns. Second, by looking for H.E.R., it is possible to clearly distinguish entrepreneurship from other fields of research.

Originality/value

To the best of the author’s knowledge, this paper is among the first that look for H.E.R., the heart – and not the boundaries – of entrepreneurship research. Originality consists of adopting an unusual perspective to advance entrepreneurship studies and contribute to the international debate about their focus.
Fostering social-emotional learning through human-centered use of generative AI in business research education: an insider case study
Authors: Aure Patrick Adriel , Cuenca Oriana
Published: June 2024

Purpose

This exploratory study innovates the pedagogy of undergraduate business research courses by integrating Generative Artificial Intelligence (GAI) tools, guided by human-centered artificial intelligence, social-emotional learning, and authenticity principles.

Design/methodology/approach

An insider case study approach was employed to examine an undergraduate business research course where 72 students utilized GAI for coursework. Thematic analysis was applied to their meta-reflective journals.

Findings

Students leverage GAI tools as brainstorming partners, co-writers, and co-readers, enhancing research efficiency and comprehension. They exhibit authenticity and human-centered AI principles in their GAI engagement. GAI integration imparts relevant AI skills to students.

Research limitations/implications

Future research could explore how teams collectively interact with GAI tools.

Practical implications

Incorporating meta-reflections can promote responsible GAI usage and develop students' self-awareness, critical thinking, and ethical engagement.

Social implications

Open discussions about social perceptions and emotional responses surrounding GAI use are necessary. Educators can foster a learning environment that nurtures students' holistic development, preparing them for technological challenges while preserving human learning and growth.

Originality/value

This study fills a gap in exploring the delivery and outcomes of AI-integrated undergraduate education, prioritizing student perspectives over the prevalent focus on educators' viewpoints. Additionally, it examines the teaching and application of AI for undergraduate research, diverging from current studies that primarily focus on research applications for academics.
The “Team Tree” Professional Tree of Life intervention: development and evaluation within the acute inpatient psychiatric setting
Authors: McDonald Claire , Townsend Jessica , Gillespie Caitlin
Published: June 2024

Purpose

Mental health staff often experience significant levels of stress working in the acute psychiatric inpatient setting. Team-building interventions can mitigate stress in health-care settings, via improvements in team-cohesion, staff interactions and communication skills. The “Tree of Life” (ToL) is a specific narrative therapy approach which uses the metaphor of a tree to facilitate the construction and sharing of strength-based stories. This study aims to describe the development of and evaluate the feasibility, acceptability and staff experiences of the “Team Tree”, an adapted Professional ToL (PToL) intervention.

Design/methodology/approach

A one-hour, Professional ToL intervention was designed for multidisciplinary acute inpatient staff teams working within a psychiatric hospital in London, UK. A mixed methods approach was used to evaluate the feasibility, acceptability and staff experiences of the session.

Findings

Participants were 46 multidisciplinary staff (33 women; 13 men) working across four acute psychiatric wards. The intervention was feasible to deliver and was acceptable to participants. Results showed significant improvements in self-reported mental well-being and team-cohesiveness scores post-session.

Practical implications

Psychologists face myriad barriers in working with staff teams in the acute inpatient setting. The “Team Tree” intervention was both well received by staff and practical to deliver within the challenging environment of the acute ward.

Originality/value

This adaptation of the original PToL emerged from the author’s work with distressed inpatient teams with limited time resources. To the best of the authors’ knowledge, this is the first description of this intervention using a single tree metaphor to facilitate a reflective and creative session with health-care teams.
Law enforcement officer naturalistic decision-making in high-stress conditions
Authors: Dailey Stephanie Fariss , Campbell Lauren N.P. , Ramsdell Justin
Published: June 2024

Purpose

This exploratory study aimed to investigate law enforcement officers’ decision-making processes in high-stress scenarios, exploring variations based on experience and how cognitive demands influence officer decision-making processes.

Design/methodology/approach

Employing a naturalistic decision-making approach and macrocognitive framework, the study utilizes scenario-based virtual reality simulations and qualitative interviews to examine the decision-making processes of law enforcement officers in high-stress policing contexts.

Findings

Thematic coding of interview data from twelve LEOs immediately following a high-stress virtual reality task revealed differences in decision-making processes and cognitive demands between novice and expert officers. Findings also revealed differences in the type of cognitive demands experienced by officers at key points in the simulated scenario.

Originality/value

The authors offer theoretical and practical contributions toward an increased understanding of officer decision-making, factors and conditions that impact LEO decisions and potential mitigation strategies that law enforcement organizations may leverage to improve officer decision-making in high-stress contexts.
Sensory experiences in hospitality industry: exploring their influence on satisfaction, decision-making and revisit intentions
Authors: Saribaş Özgür , Demir Cengiz
Published: June 2024

Purpose

The aim of this study is to investigate how sensory elements within hotels influence tourists' satisfaction, decision-making processes and intentions to revisit. Specifically, the study focuses on the sensory dimensions of hotels, namely Colorscape, Visualscape, Soundscape, Smellscape and Tastescape, and their effects on customers.

Design/methodology/approach

To comprehend these effects, interviews were conducted with 25 hotel managers, who were knowledgeable about the sensory experience framework offered by hotels. Content analysis was employed to analyze the data gathered from these interviews.

Findings

The findings of the study reveal the significant impact of sensory elements within hotels on tourists. Despite this importance, hotels may not be fully aware of the significance of sensory characteristics in enhancing the tourist experience. The study identifies the sensory dimensions as influential factors in shaping tourists' perceptions and behaviors.

Practical implications

The outcomes of this research hold practical implications for accommodation businesses in the tourism industry. By understanding and effectively managing sensory elements within hotels, businesses can gain a competitive advantage and enhance customer satisfaction. The study emphasizes the importance of addressing the sensory experience gap in tourism research and highlights the potential benefits of focusing on sensory dimensions in hotel management.

Originality/value

This study contributes to the existing literature by providing insights into the impact of sensory elements within hotels on tourist satisfaction, decision-making and revisit intention. By focusing on the sensory dimensions of hotels and exploring their influence on tourists' experiences, the research offers valuable implications for both academia and the tourism industry.
Additive partitioning of multispecies distributional aggregation of local assemblages
Authors: Wu Na , Van Chung Hoang , Shi Shengchao , Shi Xiaoqin , Liu Fangyao , Jiang Jianping , Chen Youhua
Published: June 2024

The distribution of species is not random in space. At the finest‐resolution spatial scale, that is, field sampling locations, distributional aggregation level of different species would be determined by various factors, for example spatial autocorrelation or environmental filtering. However, few studies have quantitatively measured the importance of these factors.

In this study, inspired by the statistical properties of a Markov transition model, we propose a novel additive framework to partition local multispecies distributional aggregation levels for sequential sampling‐derived field biodiversity data. The framework partitions the spatial distributional aggregation of different species into two independent components: regional abundance variability and the local spatial inertia effect.

Empirical studies from field amphibian surveys through line‐transect sampling in southwestern China (Minya Konka) and central‐southern Vietnam showed that local spatial inertia was always the dominant mechanism structuring the local occurrence and distributional aggregation of amphibians in the two regions with a latitudinal gradient from 1200 to nearly 4000 m. However, regional abundance variability is still nonnegligible in highly diverse tropical regions (i.e. Vietnam) where the altitude is not higher than 2000 m.

In summary, we propose a novel framework that shows that the multispecies distributional aggregation level can be structured by two additive components. The two partitioned components could be theoretically independent. These findings are expected to deepen our understanding of the local community structure from the perspective of both spatial distribution and regional diversity patterns. The partitioning framework might have potential applications in field ecology and macroecology research.
Comparative proteomics of a versatile, marine, iron‐oxidizing chemolithoautotroph
Authors: Barco Roman A. , Merino N. , Lam B. , Budnik B. , Kaplan M. , Wu F. , Amend J. P. , Nealson K. H. , Emerson D.
Published: June 2024

This study conducted a comparative proteomic analysis to identify potential genetic markers for the biological function of chemolithoautotrophic iron oxidation in the marine bacterium Ghiorsea bivora. To date, this is the only characterized species in the class Zetaproteobacteria that is not an obligate iron‐oxidizer, providing a unique opportunity to investigate differential protein expression to identify key genes involved in iron‐oxidation at circumneutral pH. Over 1000 proteins were identified under both iron‐ and hydrogen‐oxidizing conditions, with differentially expressed proteins found in both treatments. Notably, a gene cluster upregulated during iron oxidation was identified. This cluster contains genes encoding for cytochromes that share sequence similarity with the known iron‐oxidase, Cyc2. Interestingly, these cytochromes, conserved in both Bacteria and Archaea, do not exhibit the typical β‐barrel structure of Cyc2. This cluster potentially encodes a biological nanowire‐like transmembrane complex containing multiple redox proteins spanning the inner membrane, periplasm, outer membrane, and extracellular space. The upregulation of key genes associated with this complex during iron‐oxidizing conditions was confirmed by quantitative reverse transcription‐PCR. These findings were further supported by electromicrobiological methods, which demonstrated negative current production by G. bivora in a three‐electrode system poised at a cathodic potential. This research provides significant insights into the biological function of chemolithoautotrophic iron oxidation.
Dealing with callers’ racialised talk in suicide preventive helplines: Accomplishing (anti)racism in the context of unconditional support
Authors: Iversen Clara , Flinkfeldt Marie , Hamed Sarah
Published: June 2024

This article investigates how mental health counsellors on helplines in Sweden deal with racism from callers who self‐categorise as non‐racialised. Previous studies have identified racism as a problem in health care interactions, but there is limited knowledge about the features of racialised talk and how staff respond. In this study, we use conversation analysis and membership categorisation analysis to examine racialised talk in 17 audiorecorded calls, a subset of 458 calls to suicide preventive helplines. The analysis shows that racialisation functions as a resource for callers to make sense of their mental health difficulties. This speaks to the complexity of responding to racism in a mental health setting, as counsellors must see to callers’ needs, and calling out racialised talk may alienate callers. Call‐takers manage this problem in three ways: (1) questioning racialised talk, (2) supporting the callers’ stance in a way that makes it ambiguous if call‐takers are coproducing racism or affiliating with callers’ lives being difficult and (3) supporting callers’ problems as mental health issues while resisting a potentially racist trajectory. The study offers direct insight into the workings of racism in health care and how practitioners can balance health care users' needs for support with an antiracist position.
Maternal morbidity and death associated with pregnancy loss before 28 weeks in Nigeria
Authors: Etuk Saturday J. , Orazulike Ngozi , Abasiattai Aniekan M. , Omo‐Aghoja Lawrence O. , Njoku Anthonia , Ande Adedapo B. , Uwagboe Charles , Igbarumah Solomon , Ibrahim Isa Ayuba , Ekpebe Patrick , Ochigbo Sunny , Nyong Eno Etim , Ibeawuchi Amarabia , Idemudia Ebe , Okagua Joyce , Eigbedion Andrew , Ezekwe Bose , Adeyemi Oyedeji Oladele , Lavin Tina , Tukur Jamilu
Published: June 2024

Objective

To determine the prevalence of maternal morbidity and death from pregnancy loss before 28 weeks in referral‐level hospitals in Nigeria.

Design

Secondary analysis of a nationwide cross‐sectional study.

Setting

Fifty‐four referral‐level hospitals.

Population

Women admitted for complications arising from pregnancy loss before 28 weeks between 1 September 2019 to 31 August 2020.

Methods

Frequency and type of pregnancy loss were calculated using the extracted data. Multilevel logistic regression was used to determine sociodemographic and clinical factors associated with early pregnancy loss. Factors contributing to death were also analysed.

Main outcome measures

Prevalence and outcome of pregnancy loss at <28 weeks; sociodemographic and clinical predictors of morbidity after early pregnancy loss; contributory factors to death.

Results

Of the 4798 women who had pregnancy loss at <28 weeks of pregnancy, spontaneous abortion accounted for 49.2%, followed by missed abortion (26.9%) and ectopic pregnancy (15%). Seven hundred women (14.6%) had a complication following pregnancy loss and 99 women died (2.1%). Most complications (26%) and deaths (7%) occurred after induced abortion. Haemorrhage was the most frequent complication in all types of pregnancy loss with 11.5% in molar pregnancy and 6.9% following induced abortion. Predictors of complication or death were low maternal education, husband who was not gainfully employed, grand‐multipara, pre‐existing chronic medical condition and referral from another facility or informal setting.

Conclusion

Pregnancy loss before 28 weeks is a significant contributor to high maternal morbidity and mortality in Nigeria. Socio‐economic factors and delays in referral to higher levels of care contribute significantly to poor outcomes for women.
The Valuation of Loss Firms: A Stock Market Perspective
Authors: Mohrschladt Hannes , Siedhoff Susanne
Published: June 2024

The proportion of exchange‐listed firms with negative earnings has increased to over 40% in recent years. Previous research shows that the valuation of these loss firms is comparably difficult due to their uncertain future earnings path. Given these valuation issues, we argue that the stocks of loss firms should be particularly prone to mispricing such that simple firm value proxies might allow the prediction of subsequent stock returns. Supporting this hypothesis empirically, we find that book‐to‐market and revenue‐to‐price positively predict the cross‐section of loss firms’ stock returns. In particular, these value effects are significantly stronger compared to gain firms. Our further analyses support a behavioural mechanism for the empirical observations as the return predictability is disproportionately strong around earnings announcements and as analysts are too optimistic for loss firms with low values of book‐to‐market and revenue‐to‐price. Our analyses on short selling and option trading indicate that sophisticated investors are aware of the documented return predictability, but limits to arbitrage prevent an immediate correction of mispricing.
Examining early adherence measures as predictors of subsequent adherence in an intensive longitudinal study of individuals in mutual help groups: One day at a time
Authors: McCool Matison W. , Schwebel Frank J. , Pearson Matthew R. , Tonigan J. Scott
Published: June 2024

Background

Individuals with a substance use disorder complete ecological momentary assessments (EMA) at lower rates than community samples. Previous research in tobacco users indicates that early log‐in counts to smoking cessation websites predicted subsequent smoking cessation website usage. We extended this line of research to examine individuals who are seeking to change their drinking behaviors through mutual support groups. We examined whether adherence in the first 7 days (1487 observations) of an intensive longitudinal study design could predict subsequent EMA protocol adherence (50% and 80% adherence separately) at 30 (5700 observations) and 60 days (10,750 observations).

Methods

Participants (n = 132) attending mutual‐help groups for alcohol use completed two assessments per day for 6 months. We trained four classification models (logistic regression, recursive partitioning, support vector machines, and neural networks) using a training dataset (80% of the data) with each of the first 7 days' cumulative EMA assessment completion. We then tested these models to predict the remaining 20% of the data and evaluated model classification accuracy. We also used univariate receiver operating characteristic curves to examine the minimal combination of days and completion percentage to best predict subsequent adherence.

Results

Different modeling techniques can be used with early assessment completion as predictors to accurately classify individuals that will meet minimal and optimal adherence rates later in the study. Models ranged in their performance from poor to outstanding classification, with no single model clearly outperforming other models.

Conclusions

Traditional and machine learning approaches can be used concurrently to examine several methods of predicting EMA adherence based on early assessment completion. Future studies could investigate the use of several algorithms in real time to help improve participant adherence rates by monitoring early adherence and using early assessment completion as features in predictive modeling.
Global association of secondhand smoke exposure locations and smoking behaviour among adolescents in 99 countries
Authors: Hong Seohyun , Son Yejun , Lee Hyeri , Kim Soeun , Kim Hyeon Jin , Jo Hyesu , Park Jaeyu , Lee Kyeongmin , Lee Hayeon , Dragioti Elena , Fond Guillaume , Boyer Laurent , López Sánchez Guillermo F. , Tully Mark A. , Rahmati Masoud , Smith Lee , Kim Sunyoung , Woo Selin , Yon Dong Keon
Published: June 2024

Aim

This study classified 99 countries into four income groups and then analysed the impact of secondhand smoke (SHS) exposure at home, in public places and at school, on current cigarette smoking prevalence.

Methods

We utilised data from the WHO Global Youth Tobacco Survey and a meta‐analysis was conducted to evaluate the prevalence and weighted odds ratios (wORs) of adolescent smoking behaviour and SHS exposure locations.

Results

Both smoking behaviours increased with higher national income levels. Smoking behaviours in high and upper‐middle‐income countries (HICs and UMICs) exhibited an association with SHS exposure in public places (HIC: wOR, 3.50 [95% CI, 2.85–4.31]; UMIC: wOR, 2.90 [2.60–3.23]) compared to home. Low‐ and lower‐middle‐income countries (LICs and LMICs) showed an association with SHS exposure in the home (LIC: wOR, 5.33 [3.59–7.93]; LMIC: wOR, 2.71 [2.33–3.17]) than public places. The association between current cigarette smoking and SHS exposure at home increased with lower income levels, while anticipated future use of any form of tobacco with SHS exposure in public places rose in lower income countries.

Conclusions

Targeted interventions based on income levels are essential, emphasising home strategies in lower income countries and public place efforts in higher income countries.
Study on the mechanism of quercetin in Sini Decoction Plus Ginseng Soup to inhibit liver cancer and HBV virus replication through CDK1
Authors: Hao Liyuan , Li Shenghao , Chen Guo , Nie Aiyu , Zeng Liang , Xiao Zhonghui , Hu Xiaoyu
Published: June 2024

Background

To explore the anti‐tumor and anti‐virus key active ingredients of Sini Decoction Plus Ginseng Soup (SNRS) and their mechanisms.

Methods

The main ingredients of SNRS were analyzed by network pharmacology, and quercetin was identified as the key active ingredient. Then, we obtained the targets of quercetin by using Drugbank, PharmMapper, and SwissTargetPrediction databases. Then, the targets of HBV‐related hepatocellular carcinoma (HBV‐related HCC) were obtained by using Genecards database. In addition, using the gene expression profiles of HBV‐related HCC patients in GEO database and the genes with the greatest survival difference in GEPIA 2 database identified the potential targets of quercetin. In addition, the mechanism of potential genes was studied through GO, KEGG analysis, and PPI network. Using AUC and survival analysis to evaluate the diagnostic and prognostic value of cyclin‐dependent kinase 1 (CDK1) and CCNB1. Finally, the effects of quercetin on proliferation of Hep3B and HepG2215 cells and the level of CDK1 and CCNB1 were verified in vitro. ELISA was used to measure the expression levels of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) after the intervention by quercetin for 24 h and 48 h in HepG2215 cell.

Results

The first 10 key ingredients of SNRS were identified, and quercetin was the most key ingredient. The 101 potential quercetin targets were identified for the treatment of HBV‐related HCC. GO and KEGG showed that 101 potential target enrichment in cancer and cell cycle regulation. By Venn analysis, CDK1 and CCNB1 were intersection targets, which could be used as potential targets for the action of quercetin on HBV‐related HCC. Moreover, the expression of CDK1 and CCNB1 was highly expressed in the high‐risk group, while the OS rate was low. The 1‐year, 3‐year and 5‐year area under the curve (AUC) curves of CDK1 and CCNB1 were 0.724, 0.676, 0.622 and 0.745, 0.678, 0.634, respectively. Moreover, experimental results also showed that quercetin inhibited cell proliferation and reduced CDK1 expression in Hep3B and HepG2215 cells. The expressions of HBsAg and HBeAg in HepG2215 cell supernatant and cell gradually decreased with the increase of intervention time of quercetin and CDK1 inhibitor.

Conclusions

Quercetin is a key ingredient of anti‐HBV‐related HCC activity and inhibits HBV replication in SNRS by inhibiting CDK1.
Non‐dilated left ventricular cardiomyopathy with arrhythmias is commonly caused by the nonsense variant DSP:c.3793G>T in Slovenian patients
Authors: Vodnjov Nina , Zupan Mežnar Anja , Maver Aleš , Dolinšek Ajda , Peterlin Borut , Writzl Karin
Published: June 2024

DSP‐cardiomyopathy has recently been recognised as a specific type of cardiomyopathy. Using an in‐house Mendelian disease registry, we aimed to identify probands with likely pathogenic or pathogenic DSP variants. We detected these variants in 4.8% and 77.8% of genotype‐positive probands referred for dilated and non‐dilated left ventricular cardiomyopathy (NDLVC), respectively. We identified six Slovenian probands with the DSP:c.3793G>T and characterised them along with further eight of their relatives at the molecular and phenotypic level. Medical records revealed NDLVC with arrhythmia in six individuals (five probands, one relative; 33 ± 14 years; three males, three females). All had subepicardial late gadolinium enhancement on cardiac MRI (CMRI), and five received an ICD. Four individuals (one proband, three relatives; 48 ± 14 years; all female) had no ECG and/or cardiac abnormalities on CMRI detected. Our analysis presents a Slovenian‐specific molecular pathology of DSP cardiomyopathy, delineates the clinical manifestation of DSP:c.3793C>T, and thereby improves the understanding of the clinical outcomes associated with truncating DSP variants.
Clinical and radiographic outcomes of implant‐supported fixed prostheses with cantilever extension in anterior mandible: A retrospective study
Authors: Wang Siyuan , Chen Xiaoyu , Ling Zhaoting , Xie Yiwen , Chen Cong , Shen Xiaoting , He Fuming
Published: June 2024

Objectives

The objective of this study is to analyze the clinical and radiographic outcomes of implant‐supported fixed protheses with cantilever extensions (ISFPCs) in the partially edentulous anterior mandible.

Materials and Methods

Patients who received anterior mandible implant restoration between January 2016 and December 2021 were included. Patients with two, three, or four continuous missing teeth receiving adjacent implant supported single‐unit crowns (ISSCs), ISFPCs, implant‐supported fixed protheses without cantilever extensions (ISFPNs) were divided into groups: ISSC+ISSC, ISFPC, ISSC+ISFPC, three‐unit ISFPN, ISFPC+ISFPC, or four‐unit ISFPN, respectively. We recorded and evaluated survival rates, mechanical and biological complications, peri‐implant marginal bone loss (MBL), esthetic outcomes, and patient perceptions. Statistical analysis was performed using linear mixed models (LMM).

Results

The study included 87 patients and 152 implants. No implant loss occurred during an average follow‐up of 3.48 ± 1.85 years (range: 1–7 years). According to LMM models, prosthetic type had a statistically significant impact on MBL during follow‐up periods, in favor of the ISFPC and ISFPC+ISFPC groups (0.16 ± 0.48 mm vs. 0.51 ± 0.49 mm, p = .034; 0.22 ± 0.49 mm vs. 0.60 ± 0.62 mm, p = .043, respectively). Mechanical and biological complications were relatively low and comparable. The four‐unit ISFPC group had higher subjective esthetic scores compared with the ISSC+ISSC group (98.6 vs. 83.8, p < .05), and patients in the ISFPC+ISFPC group expressed greater satisfaction with cleanability than the ISFPN group (98.8 vs. 80.6).

Conclusion

ISFPCs offer a highly predictable treatment option in the anterior mandible, characterized by high survival rates, and comparable complication rates, peri‐implant bone stability and esthetics to adjacent ISSCs or ISFPNs.
Islamic faith‐based organisations and their role in building social capital for post‐disaster recovery in Indonesia
Authors: Nurdin Muhammad Riza
Published: June 2024

This paper investigates the role of Islamic faith‐based organisations (FBOs) in Indonesia and examines the way in which their disaster recovery aid can be successful or less successful depending on social capital formation in communities affected by a disaster. The paper argues that Islamic FBOs play a prominent role in disaster‐affected communities by building new social capital or strengthening existing social capital. Failure to do so may affect a community's recovery and its long‐term resilience. Applying a framework that considers three types of social capital—bonding, bridging, and linking—from a comparative perspective, the paper discusses two cases of disaster recovery: one following the earthquake that struck Aceh in 2013; and the other after the Mount Kelud volcanic eruptions in East Java in 2014. In both instances, the findings highlight the importance of the village facilitator, cultural sensitivity, and understanding of local indigenous and religious practices for successful disaster recovery.
Key results from observational studies and real‐world evidence of sodium‐glucose cotransporter‐2 inhibitor effectiveness and safety in reducing cardio‐renal risk
Authors: Nyström Thomas
Published: June 2024

Sodium‐glucose cotransporter 2 (SGLT2) inhibitors, originally designed to manage blood sugar levels in individuals with type 2 diabetes (T2D), have emerged as a crucial class of drugs for managing cardio‐renal diseases. These drugs work by targeting the SGLT2 protein in the kidneys, promoting the excretion of glucose and influencing metabolic pathways beyond glucose control. The relationship between cardio‐renal diseases and SGLT2 inhibitors has been explored through landmark trials and real‐world evidence (RWE) studies, demonstrating significant reductions in cardio‐renal complications. This review discusses the importance of RWE studies alongside randomized controlled trials in understanding the real‐world effectiveness and safety of SGLT2 inhibitors. It outlines the advantages and disadvantages of RWE compared to RCTs, highlighting their complementary roles in providing comprehensive insights into treatment outcomes. By examining a range of RWE studies, the review underscores the cardio‐renal benefits of SGLT2 inhibitors across various patient populations. Safety assessments indicate that SGLT2 inhibitors are generally well tolerated, with severe adverse events being rare. Common issues, such as genital mycotic infections and urinary tract infections, are acknowledged, alongside less frequent but significant adverse events including diabetic ketoacidosis, lower‐limb amputations, and bone fractures. In summary, SGLT2 inhibitors show promising cardio‐renal protective effects in real‐world scenarios across diverse populations in T2D, indicating their potential as early intervention measures. Continued research is essential for gaining a thorough understanding of their long‐term effects and safety profiles.
The how and how much of technology use in the classroom: A motivational approach to teachers' technology use
Authors: David Loukia , Weinstein Netta
Published: June 2024

Technology in the classroom can facilitate learning, but little is known about how the motivational climate set by teachers shapes its impacts on students. Informed by self‐determination theory, the current study explored technology use in English language classrooms to understand how autonomy‐supportive and structured teaching styles influenced positive outcomes of classroom technology use. Teachers (N = 101) reported on technology use and motivational styles, and students (N = 550) aged 9–16 years reported on basic psychological needs satisfaction (autonomy, relatedness and competence) and academic well‐being (interest and effort). Findings of nested models showed no direct benefits for the amount of technology use; more autonomous teaching style and low structure linked to students' need satisfaction and interest. Beyond these main effects, when teachers were more autonomous, using technology enhanced student need satisfaction and interest; the combination of both was most beneficial for these student outcomes. Counter to expectations, when teachers had low structure technology use enhanced their impact on students. Findings suggest that to optimize student well‐being and interest in learning, teachers benefit from combining autonomy‐supportive education styles and technology use.
Enhancing education quality: Exploring teachers' attitudes and intentions towards intelligent MR devices
Authors: Chen Yuyu , Zou Yuntao
Published: June 2024

This research paper focuses on the adoption of multi‐perspective theory to study teachers' attitudes and intentions towards using intelligent mixed reality (MR) devices for classroom behaviour analysis. The research model integrates TRI (Technology Readiness Index), IDT (Innovation Diffusion Theory), ECM (Expectation Confirmation Theory) and TAM (Technology Acceptance Model) model. The variable of insecurity is considered to address the concerns regarding information security in the use of artificial intelligence in education. The study identifies that innovation and relative advantage significantly and positively influence teachers' attitudes towards using intelligent MR devices. PeoU (perceived ease of use), however, does not have a significant impact on attitudes, suggesting that teachers prioritize the benefits of enhancing teaching quality over the complexity of the devices. PU (perceived usefulness) emerges as a key variable for teachers' adoption of intelligent MR devices, prompting the need for attention from designers and manufacturers. Regression analysis reveals that gender does not influence the use of new technology, while teachers with more teaching experience and those working in remote areas express greater receptiveness towards utilizing new technology. The paper recognizes the potential of intelligent teaching devices to address educational challenges and promote equity in remote areas by providing auxiliary tools for teachers to improve teaching efficiency and quality. Teacher training and technical support are emphasized as crucial factors for effective use of artificial intelligence teaching devices.
Predicting international student satisfaction in Chinese universities: A comparison between undergraduate and graduate students
Authors: Zhao Kai , Ma Jiani
Published: June 2024

With the rapid growth in the number of international students coming to China, improving the quality and effectiveness of international student education has become a new policy priority. This study investigates the quality issue from the perspective of student satisfaction, with a focus on how satisfaction varies by academic level. We analysed data from a national survey involving 1,322 international students studying at Chinese colleges and universities using ordered logit regression models. The results indicate that most international students are satisfied with the host institutions. Both individual and environmental factors are significantly associated with the level of student satisfaction and these associations are different among undergraduate and graduate students. These findings underscore the importance of tailoring support to meet the distinct needs of students at different academic stages and suggest that universities can enhance student satisfaction by fostering a supportive interpersonal environment.
Connecting the dots: Sensory cueing enhances functional connectivity between pre‐motor and supplementary motor areas in Parkinson's disease
Authors: Zadeh Ali K. , Sadeghbeigi Narges , Safakheil Hosein , Setarehdan Seyed Kamaledin , Alibiglou Laila
Published: June 2024

People with Parkinson's disease often exhibit improvements in motor tasks when exposed to external sensory cues. While the effects of different types of sensory cues on motor functions in Parkinson's disease have been widely studied, the underlying neural mechanism of these effects and the potential of sensory cues to alter the motor cortical activity patterns and functional connectivity of cortical motor areas are still unclear. This study aims to compare changes in oxygenated haemoglobin, deoxygenated haemoglobin and correlations among different cortical regions of interest during wrist movement under different external stimulus conditions between people with Parkinson's disease and controls. Ten Parkinson's disease patients and 10 age‐ and sex‐matched neurologically healthy individuals participated, performing repetitive wrist flexion and extension tasks under auditory and visual cues. Changes in oxygenated and deoxygenated haemoglobin in motor areas were measured using functional near‐infrared spectroscopy, along with electromyograms from wrist muscles and wrist movement kinematics. The functional near‐infrared spectroscopy data revealed significantly higher neural activity changes in the Parkinson's disease group's pre‐motor area compared to controls (p = 0.006), and functional connectivity between the supplementary motor area and pre‐motor area was also significantly higher in the Parkinson's disease group when external sensory cues were present (p = 0.016). These results indicate that external sensory cues' beneficial effects on motor tasks are linked to changes in the functional connectivity between motor areas responsible for planning and preparation of movements.
Selective knockdown of GABAA‐α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity
Authors: Tripathi Kuldeep , Hazra Somoday , Hazra Joyeeta Dutta , Mandel Silvia , Anunu Ruchi , Kriebel Martin , Volkmer Hansjurgen , Richter‐Levin Gal
Published: June 2024

Animal studies and clinical trials suggest that maintenance of gamma‐aminobutyric acid (GABA)‐ergic activity may be crucial in coping with stressful conditions, anxiety and mood disorders. Drugs highly efficient in promoting anxiolysis were shown to activate this system, particularly via the α2‐subunit of type A receptors (GABAA α2). Given the high expression of GABAA α2 in the dentate gyrus (DG) sub‐field of the hippocampus, we sought to examine whether manipulation of the α2 subunit in this area will evoke changes in emotional behaviour, memory and learning as well as in synaptic plasticity. We found that knockdown of GABAAα2 receptor specifically in the dorsal DG of rats caused increased anxiety without affecting locomotor activity. Spatial memory and learning in the Morris water maze were also impaired in GABAAα2 receptor knocked down rats, an effect accompanied by alterations in synaptic plasticity, as assessed by long‐term potentiation in the DG. Our findings provide further support to the notion that emotional information processing in the hippocampus may be controlled, at least in part, via the inhibitory GABAA α2 receptor subunit, opening a potential avenue for early interventions from pre‐ puberty into adulthood, as a strategy for controlling anxiety‐related psychopathology.