bluuebunny/crossref_metadata_2025 huggingface dataset:
واقع التعليم في الولايات المتحدة الأمريكية: التحديات والفرص وآفاق الإصلاح
Authors: حسين احمد دعيس , بخيت حيدر نعمة , الموسوي عبد الوهاب محمد جواد , الاسدي أريج سعد عبدالعالي , محمد دلوفان أسعد
Published: December 2024

على الرغم من ان الولايات المتحدة الامريكية تعد اغنى دولة في العالم بناتج محلي اجمالي وصل في عام 2022 الى اكثر من 25 ترليون دولار، وتنفق على التعليم 12.5% من اجمالي الانفاق الحكومي، الا ان نظام التعليم لديها يواجه العديد من التحديات، منها التفاوت في التمويل، والنتائج التعليمية المتباينة، واختلاف الوصول إلى التعليم الجيد عبر المناطق والمجموعات السكانية المختلفة، والعنف المسلح اذ تمتلك حوالي 50% من الاسر الامريكية قطعة سلاح ناري على الاقل، وغيرها. يهدف هذا البحث إلى دراسة هذه التحديات بشكل شامل، مع التركيز على كيفية تأثيرها على أداء الطلبة والنتائج المجتمعية على المدى الطويل. لذا تأتي أهمية البحث من ان فهم واقع التعليم في الولايات المتحدة يعد أمرًا بالغ الأهمية لواضعي السياسات التعليمية وأصحاب المصلحة لتطوير استراتيجيات مستنيرة تعزز المساواة والتميز في التعليم. وهذا البحث يسلط الضوء على المجالات الرئيسية التي تحتاج إلى التدخل، مما يوفر الأساس لتغييرات سياسية فعالة وإصلاحات تعليمية متعددة المستويات.
    تتمثل الأهداف الرئيسية للبحث بتحليل التفاوت في التمويل والموارد التعليمية بين المناطق التعليمية المختلفة، وتقييم أثر هذه الفوارق على الأداء الأكاديمي للطلبة ومعدلات التخرج، وتقييم مدى فعالية السياسات التعليمية الحالية في معالجة عدم المساواة، ومن ثم اقتراح توصيات لتحسين المساواة والجودة في نظام التعليم في الولايات المتحدة.
     يستخدم البحث أساليب بحثية متعددة من خلال الجمع بين تحليل البيانات الكمية ودراسات الحالة النوعية. وتم الحصول على البيانات كأعداد الملتحقين، ومستويات التمويل، ودرجات الاختبارات الموحدة، ومعدلات التخرج، من المصادر الرسمية ومن الدراسات والبحوث المختلفة.
     ان اهم النتائج التي توصل اليها البحث هي وجود اختلافات كبيرة في التمويل لكل طالب عبر الولايات والمناطق التعليمية، ويتأثر ذلك إلى حد كبير بالضرائب المحلية.  واهم الاستنتاجات التي توصل اليها البحث هي أن نظام التعليم في الولايات المتحدة يتميز بتفاوتات كبيرة تعيق التطور الأكاديمي والاجتماعي للطلبة في المناطق التي تعاني من نقص الموارد.
Orthopedic rehabilitation of a patient after total resection of the maxilla (clinical case)
Authors: Dementyeva E. A. , Oreshaka O. V. , Shvets M. V.
Published: December 2024

Extensive surgical interventions are accompanied by the formation of defects in the maxillofacial area, which raises serious concerns regarding the functional, cosmetic, and social rehabilitation of patients. This article, using a clinical case as an example, describes the stages of rehabilitation of a female patient with a postoperative total maxillary defect through the use of a complete removable denture with an obturator. The use of orthopedic rehabilitation methods for patients after maxillary resection enables positive results in restoring lost functions of the dentoalveolar system, facilitating better adaptation of such patients in society and allowing them to return to an active life.
Low level laser therapy in management of post endodontic retreatment pain: A review
Authors: Humnabad V. K. , Kashikar R. , Hindlekar A. , Srinidhi S. R. , Adapa S. Sh.
Published: December 2024

Post-endodontic treatment pain is frequent which needs analgesics for patient’s pain relief. One of the most common reasons for post operative pain is chemical, mechanical, or microbial injuries to the periapical tissues that result in acute inflammation. Application of recently developed endodontic techniques and devices will reduce postoperative pain. Two proven methods for reducing pain associated with inflammation are low-level laser therapy (LLLT) and antimicrobial photodynamic therapy. The use of LLLT in root canal therapy procedures is supported by more and better-documented evidence.
Assessment of the association between the components of the metabolic syndrome and the pathology of dental hard tissues and inflammatory periodontal diseases
Authors: Senina V. O. , Usmanova I. N. , Lakman I. A. , Gerasimova L. P. , Ishmukhametova A. N. , Makarova N. A. , Berezin V. A.
Published: December 2024

AIM. Is to assess the interaction between the pathology of carious and non-carious dental hard tissues, inflammatory periodontal diseases and components of the metabolic syndrome (MS).

MATERIALS AND METHODS. A retrospective observational and comprehensive dental examination of 105 patients with MS has been performed. The complex of dental examination included analysis of complaints, anamnesis, assessment of the condition of dental hard tissues, and periodontal tissues. As a result of retrospective observational analysis, 3 clinical groups have been formed as follows: 2 main clinical groups with MS with impaired carbohydrate metabolism, and with type 2 diabetes mellitus, as well as a group with MS without impaired carbohydrate metabolism (experimental group).

RESULTS. The caries prevalence rate in patients of the 1st and 2nd main clinical groups according to WHO criteria is high, that is 92.5% and 97.3%, (р < 0.001), the average caries intensity level according to the DMF index (Decayed, Missing, Filled index) corresponds to the criterion of high and very high (< 0.001), there is a prevalence of increased abrasion in 76.3% and 51.0% (р < 0.05), hyperesthesia in 69.2% and 67.3%, wedge-shaped defects of hard tissues in 57.7% and 46.2% (р < 0.001), in 34.6% and 80.8% of cases there is a prevalence of chronic periodontitis (р < 0.001) as compared to the experimental group. In this category of patients, the median value of hygienic (SOHI / Simplified Oral Health Index) and periodontal indices of SBI, PI, periodontal pocket depth have been statistically and significantly different from the experimental group patients according to the Kruskal Wallis Test, р < 0.01.

CONCLUSIONS. Thus, in patients with metabolic syndrome with impaired carbohydrate metabolism and type 2 diabetes mellitus, the prevalence of carious and non-carious tooth hard tissue pathology and periodontal inflammatory diseases is observed among the main dental diseases. The data obtained require an interdisciplinary approach in the development and planning of early qualitative diagnostic and treatment and preventive interventions maneuvers in conjunction with a dentist, endocrinologist, and a therapist.
EFL Students’ Voices of Willingness to Communicate in Learning Interaction at the University Level
Authors: Artha Anggraini  Kesuma Dwindha , Susanto Fajar
Published: December 2024

One of the affective factors which influences the success of foreign language learning is Willingness to Communicate (WTC). WTC is a student’s tendency to involve or not to engage in a communication in a foreign language learning. This study aims to investigate the contributing factors influencing student’s willingness to communicate in English as a foreign language (EFL) at the university level. This research adopted a qualitative case study where interviews were conducted with four students of English Language Education Department at AB University in Surabaya and observations were also carried out to get additional information. Personal interviews were utilized to obtain primary data, while observation was used as complementary data focusing only on question-and-answer activities during the learning process. The findings of this study show that having English partner, self-confident, achievement in the study, interesting topic are the clear factors of the EFL student's willing to communicate in learning process. Therefore, it is advised that English teachers focus more on certain factors that affect students' WTC in order to assist the students in raising their WTC, which improves speaking.
Stop Cyberbullying Pencetus Kerusakan Mental Melalui Kampanye End Cyberbullying
Authors:   Universitas Bakrie, Revansyah Said , Marshall Steven , Puspita Tiara , Ramadhan Muhammad , Putra Rangga Bayu , Purnama Ken Ayuthaya , Lestari Annisa Fitriana
Published: December 2024

Kampanye "End Online Bullying" diluncurkan sebagai respons terhadap meningkatnya kasus perundungan online dan dampaknya yang merusak. Kampanye ini bertujuan untuk meningkatkan kesadaran masyarakat mengenai bahaya cyberbullying, serta memberikan edukasi tentang cara mencegah dan mengatasi masalah ini. Kampanye ini mengajak semua pihak, termasuk individu, komunitas, institusi pendidikan, dan pemerintah, untuk berperan aktif dalam menciptakan lingkungan online yang aman dan positif.
Literature Review Artikel: MANFAAT MINYAK ATSIRI PADA BERBAGAI BAGIAN TUMBUHAN
Authors: Fikayuniar Lia , Audiny Cindy , Ibrahim Asshasyfa , Hidayat Dhivira Azfari Pratama , Julianti Dine , Ramadhani Putri , Zaenudin Rian Ahmad
Published: December 2024

Essential oils are aromatic compounds naturally found in various parts and types of plants. This study aims to evaluate the benefits of essential oils extracted from different plant parts using various methods. The research was conducted through a literature review by analyzing data from multiple journal articles. The review revealed that essential oils extracted from different plant parts exhibit diverse compositions and benefits. Essential oil from the leaves of zodia (Evodia suaveolens), obtained through distillation, yielded 0.6471%, with 4(5H)-Benzofuranone identified as the main component through GC-MS analysis. Meanwhile, hydro-steam distillation of kaffir lime (Citrus hystrix) peel produced essential oil containing 25 components, primarily demonstrating antioxidant activity. Steam distillation of langsat (Lansium domesticum) fruit peel yielded essential oil with a 0.18% yield, comprising monoterpenoid and sesquiterpenoid compounds as its major components. This study highlights the potential of essential oils from various plant parts as sources of bioactive compounds with diverse benefits.
EVALUASI TINGKAT KUALITAS KEPUASAN PASIEN PADA PELAYANAN INSTALASI FARMASI RUMAH SAKIT DIINDONESIA (Narrative Review)
Authors: Milara sukma Sischa , Wahyuningsih Sri
Published: December 2024

Good quality standards for health services are a level of perfection in health services, giving rise to a feeling of satisfaction in patients. This means that the more perfect the patient's satisfaction, the better the quality of health services. The aim of this review is to determine the level of patient satisfaction in hospital pharmacy installation services in Indonesia and to find out what factors influence the level of patient satisfaction in hospital pharmacy installations. . This review uses a narrative review which uses articles or journals published in 2014 -2024. The literature sources were obtained from the Google Scholar and Pud Med websites, namely 10 journals and were included in the inclusion criteria. The results obtained show that the friendliness of the staff, speed in administering medication, and comfortable facilities and infrastructure can increase patient satisfaction. In conclusion, the level of patient satisfaction is a reflection of the level of satisfaction in health services. The level of patient satisfaction is influenced by many factors, including the provision of drug information, the timeliness of drug administration services, the friendly attitude of staff, and the comfort of facilities and infrastructure which can increase patient satisfaction. Assessment of the quality of patient satisfaction services covers five main dimensions including: physical evidence, reliability, responsiveness, assurance and empathy.
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN FACIAL WASH EKSTRAK ETANOL DAUN MATOA (Pometia Pinnata J.R & G. Forst.)
Authors: Dzakiyyatunnisa Hanifah , Nawangsari Desy , Samodra Galih
Published: December 2024

Kulit wajah adalah bagian tubuh yang selalu terpapar debu, polusi, sinar ultraviolet, radikal bebas bahkan seringkali sisa sisa riasan jika tidak dibersihkan dengan baik. Oleh karena itu, kulit wajah harus mendapat perhatian ekstra agar tetap terjaga dengan baik. Perawatan wajah awal bisa dilakukan secara rutin dengan menggunakan pembersih wajah. Namun banyak pembersih wajah yang mengandung bahan kimia sintetis seperti triclosan yang dapat menyebabkan disfungsi tiroid. Untuk mengatasinya, Anda bisa menggunakan bahan alami seperti daun matoa. Ekstrak etanol daun matoa mempunyai efek antibakteri terhadap bakteri staphylococcus aureus. Tujuan penelitian ini untuk mengetahui formula facial wash ekstrak etanol daun matoa dengan uji sifat fisik dan stabilitas sediaan, untuk mengetahui respon iritasi sediaan dan untuk mengetahui kesukaan responden. Metode penelitian ini yaitu eksperimental laboratorium. Hasil pengujian organoleptik dan homogenitas didapatkan hasil yaitu tidak ada perbedaan pada formula kecuali warna pada F3 lebih coklat tua. Pengujian pH didapatkan hasil tidak memenuhi standar pH. Berdasarkan pengujian statistik diketahui bahwa viskositas mendapatkan nilai p value <0,05 yang berarti terdapat perbedaan yang signifikan dengan penggunaan konsentrasi ekstrak etanol daun matoa. Pada hasil uji stabilitas, nilai pH pada ketiga formula tidak mempunyai pengaruh yang signifikan, nilai daya sebar F3 mempunyai pengaruh yang signifikan, nilai daya busa pada F1 mempunyai pengaruh yang signifikan, nilai viskositas pada ketiga formula mempunyai pengaruh yang signifikan. Hasil uji hedonik menunjukkan F1 mendapatkan rangking kesukaan pertama dengan persentase 33,90 %.
UJI STABILITAS WARNA ANTOSIANIN EKSTRAK BUNGA TELANG PADA BERBAGAI PH DAN UJI POTENSI ANTIBAKTERI
Authors: Fitriani Dewi , Novitasari Aprilia Donna , Ariani Lilies Wahyu
Published: December 2024

Anthocyanins are flavonoid compounds that can be found in red, orange, purple, and blue coloured plants. The colour stability of these compounds is generally affected by temperature, pH and solvents. Anthocyanins tend to be stable at acidic pH and unstable at alkaline pH. Telang flower is a plant that has anthocyanin content. This anthocyanin content provides many benefits both in the health and food fields. The purpose of this study was to determine the effect of variations in solvent pH on the extraction of telang flowers on yield, extract pH, colour stability and to test antibacterial activity in extractions using alkaline solvents. This research method is to extract anthocyanins in telang flowers, using variations in solvent pH, then calculate the yield, pH of the extract, colour stability formed. This study also tested the potential antibacterial activity of extracts extracted using solvents in an alkaline atmosphere. The results showed that increasing the pH of the solvent increased the percent yield, the pH of the extract was obtained in the pH range of 4-8, with the anthocyanin content decreasing. The extract obtained has a different colour spectrum at each pH condition and the extract conditioned at alkaline pH has inhibitory activity against Staphylococcus aureus bacteria.
STUDI INTERAKSI OBAT ANTIHIPERLIPIDEMIA PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT SWASTA CIKAMPEK
Authors: Amal Andi Nurzakiah , Agustini Dewi Darwati , Amal Surya
Published: December 2024

Hyperlipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol levels in the blood, which is a risk factor for various cardiovascular diseases. Treatment of hyperlipidemia is often combined with other drugs, increasing the potential for drug interactions. This study aims to identify the severity of antihyperlipidemia drug interactions in outpatients in private hospitals in Cikampek during the period of June to December 2023. The research uses an analytical survey design with a retrospective approach. Data were obtained from 251 patient prescriptions that met the inclusion criteria and were analyzed univariably using the Stockley Drug Interaction and drugs.com application. The results showed that 67.65% of prescriptions had potential drug interactions, while 32.35% did not. Patients aged 50–59 years were the largest group (42.6%) receiving antihyperlipidemia, with simvastatin being the most frequently prescribed drug and causing drug interactions most often (51.11%). Of the 135 cases of drug interactions identified, moderate severity accounted for 57.03%, while major severity reached 46.97%. No cases with minor severity were found. This study highlights the importance of monitoring drug interactions to prevent more serious risks in hyperlipidemia patients.
FORMULASI HAND AND BODY LOTION BERBASIS EKSTRAK JAMUR LINGZHI (GANODERMA LUCIDUM) SEBAGAI SEDIAAN FOTOPROTEKTIF
Authors: Hidayat Fahmi , Rosanti Aulia Dewi , Sa’diyah Asvikatu
Published: December 2024

Ultraviolet (UV) radiation can induce various health problems, particularly on the skin as the body's protective organ. This study aimed to enhance skin protection against free radical damage by utilizing the antioxidant potential of lingzhi mushroom (Ganoderma lucidum) extract. Through the formulation of hand and body lotion, various concentrations of lingzhi mushroom extract (0%, 0.25%, 0.50%, and 0.75%) were incorporated. In vitro testing was conducted to measure the Sun Protection Factor (SPF) value as an indicator of the product's ability to protect the skin from ultraviolet radiation. The results showed an increase in SPF value with increasing concentrations of lingzhi mushroom extract. The formulation with 0.75% lingzhi mushroom extract yielded the highest SPF value of 4.4. These findings indicate that lingzhi mushroom extract has the potential to be an active ingredient in skincare products, not only providing hydration but also offering optimal protection against free radical damage and UV radiation.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN CLEANSING BALM EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.)
Authors: Farhamzah Farhamzah , Warsito Ainun Mar’atus Putri , Yuniarsih Nia
Published: December 2024

Skin is the outermost layer of the human body that protects the organs inside and skin is the layer that adapts most to the external environment, weather or climate. Facial cleansing is the first step to remove dead skin cells, dirt, sebum and cosmetic residue, which causes acne, redness, irritation and can be made worse by the presence of free radicals. Compounds that are able to ward off free radicals are antioxidants, so this research will make Cleansing Balm with butterfly pea flower extract (Clitoria ternatea L.) as an antioxidant and find out the best formula and storage stability from experimental research by testing antioxidant activity using the DPPH method. The Cleansing Balm preparation was made with three additional concentrations of butterfly pea flower extract (Clitoria ternatea L.), namely F1 (0.1%), F2 (0.2%), and F3 (0.3%). In this research, the results showed that telang flower extract contains alkaloids, flavonoids, quinones, tannins and saponins. The antioxidant activity of Cleansing Balm of butterfly pea flower (Clitoria ternatea L.) shows an IC50 F1 of 95,732 ppm, F2 of 51,368 ppm, F3 of 10,213 ppm. From the research, it can be concluded that Cleansing Balm Formula 3 which contains 0.3% butterfly pea flower extract (Clitoria ternatea L.) is the most effective formula for antioxidant activity
Aplicación de ODS: explorando las perspectivas actuales sobre la educación
inclusiva
Authors:   Universidad Nacional de Ciencias
            Forestales, Durón Corea Dunia Yolanda , Fajardo Munguía Elda Ninoska ,   Universidad Nacional de
            Ciencias Forestales, Raudales García Eli Vicente ,   Universidad Nacional de
            Ciencias Forestales
Published: December 2024

Esta investigación tuvo como propósito explorar perspectivas actuales sobre la
educación inclusiva. La metodología empleada se desarrolló bajo un enfoque cualitativo,
de tipo documental y descriptivo, fundamentado en una revisión de la literatura básica
de los últimos cinco años. Los resultados revelan diversos enfoques y avances en el
ámbito de la educación inclusiva, destacando la implementación de normativas,
directrices y políticas públicas, prácticas educativas, avances tecnológicos y los retos
actuales. Se concluye que, aunque se han logrado progresos, la educación inclusiva sigue
siendo un desafío global que requiere políticas más inclusivas, enfoques pedagógicos
adaptados y una mayor sensibilización social.
Motivaciones y desafíos de mujeres propietarias de negocio de la Ciudad de México y zona conurbada
Authors: Hernández Herrera Claudia Alejandra
Published: December 2024

El objetivo del artículo es analizar las percepciones de mujeres empresarias con relación a sus motivaciones para iniciar el negocio, sus desafíos, sus estrategias para enfrentar los retos, la importancia de la capacitación y los consejos hacia mujeres emprendedoras. Es un estudio cualitativo, en el cual se entrevistaron a ocho microempresarias de la Ciudad de México y área conurbada. Se encontró que la falta de trabajo o quedarse sin éste las motivó a iniciar sus negocios; sus desafíos fueron decidir arrancar las ideas de negocio, el machismo, y la falta de conocimiento y confianza. Se concluye que es imperante el desarrollo de programas de capacitación y acceso a mentoría que coadyuve al desarrollo de habilidades empresariales.
Teoría de Markowitz en portafolios del S&P 500
Authors: Huamani Millio Jonathan Alex , Chancolla Taquima Lisbeth Marivel , Gutiérrez Monzón Sonia Gladys
Published: December 2024

En el presente artículo se propuso como objetivo analizar la Teoría de Markowitz para identificar su incidencia en el rendimiento debido a que los inversionistas requieren optimizar el equilibrio entre riesgo y rendimiento. Metodológicamente, el estudio empleó el tipo de investigación básica con enfoque cuantitativo; además, un diseño no experimental de tipo retrospectivo y un alcance descriptivo y explicativo. En cuanto a la muestra, se utilizó la cotización histórica mensual de las acciones de las empresas listadas en el índice bursátil S&P 500 abarcando un periodo comprendido entre enero del 2023 hasta agosto 2024 y procesados a través del programa Solver. Como hallazgos se encontró que la frontera eficiente fue útil para identificar portafolios con el mismo nivel de riesgo y rendimientos diferentes, la menor dispersión de datos y el menor coeficiente beta permitieron obtener un rendimiento superior al riesgo. En ese sentido, se concluyó que la teoría de Markowitz incide favorablemente en el rendimiento de un portafolio ya que permitió identificar alternativas de inversión que simultáneamente minimizan el riesgo y maximizan el rendimiento.
Estudio exploratorio del papel de la inteligencia emocional en la innovación empresarial desde la perspectiva de los procesos organizacionales
Authors: Chinchilla Leyla Patricia
Published: December 2024

El propósito de esta investigación fue explorar el papel de la inteligencia emocional (IE) en la innovación empresarial desde la perspectiva de los procesos organizativos. Se empleó un enfoque cualitativo, documental y descriptivo, y se identificaron un total de n = 20 artículos científicos, los cuales fueron seleccionados a partir de bases de datos. Los resultados revelan que la inteligencia emocional y la innovación empresarial se destacan por su impacto y la relación entre IE, competencia emprendedora y gestión del conocimiento. Asimismo, se analizó el papel de la IE en la innovación empresarial y la eficacia gerencial, su influencia en la colaboración y el rendimiento de los equipos, su relación con la adaptación al cambio organizacional, y su vínculo con la inteligencia de negocios y la toma de decisiones, además de la productividad científica. Se concluye, que la IE es un componente esencial para la innovación empresarial, especialmente desde la perspectiva de los procesos organizativos.
Martha Nussbaum y Amartya Sen. Un análisis en torno al desarrollo humano, las libertades individuales y la capacidad de agencia
Authors: Morales Carrero Jesús Alfredo
Published: December 2024

La construcción de condiciones dignificantes de la existencia humana constituye una de las preocupaciones generalizadas a las que tanto programas de gobierno como agendas globales han dedicado especial atención, por contener las posibilidades para otorgarle trascendencia a la vida plena. Esta investigación como resultado de una revisión documental con enfoque cualitativo analiza los referentes de Martha Nussbaum y Amartya Sen en torno al desarrollo humano, las libertades individuales y la capacidad de agencia. Se utilizó el análisis de contenido para precisar relaciones, argumentos comunes y planteamientos que redunden en la concreción de posibilidades de realización humana individual y colectiva fundada en los tres constructos trabajados. Los resultados indican que el alcance de la existencia plena como ideal universal requiere la operativización de las libertades individuales y la instrumentación de la capacidad de agencia, medios garantes del funcionamiento del ser humano en cualquier contexto; posibilitándole condiciones para seleccionar alternativas y asumir oportunidades que redunden en la consolidación de la calidad de vida y el bienestar integral a lo largo del ciclo vital. Esto involucra el acceso a bienes y servicios que satisfagan requerimientos asociados con el equilibrio físico, económico, en materia de salud, así como posibilidades de empleabilidad y educación. Se concluye que, alcanzar una existencia plena requiere enfocar los esfuerzos personales, sociales e institucionales que aporten a la construcción de una vida significativamente digna, saludable y libre de restricciones socio-históricas; en las que el ser humano goce de mayores oportunidades de realización dentro de cualquier contexto.
SMART TORQUE MANAGEMENT SYSTEM WITH IOT - DRIVEN SAFETY INTEGRATION
Authors: MANNE PRIYANKA , S. VASAVI  , T. AMRUTHA  , V. RAJITHA
Published: December 2024

This paper presents an intelligent torque control system designed to enhance vehicle safety by adjusting torque output based on the type of passenger. The system is tailored to ensure the safety of children and the elderly, with torque limits set at 40 for these groups, while accommodating adults with a limit of 70. In emergency situations, the system operates without torque restrictions to allow for quick responses. Key components of the system include the ESP8266 microcontroller, LM 398N motor driver, four geared motors, Blink IoT module, a battery, and the TP 4056 charging module, all working together to deliver optimal performance. The system is equipped with three userfriendly buttons—Child, Adult, and Emergency—that allow users to easily select the appropriate torque setting. The research offers valuable contributions to vehicle safety by introducing a flexible and adaptable torque control mechanism, aimed at reducing the risks of accidents and improving overall road safety for passengers. By integrating IoT technology with intelligent torque control, this system has the potential to significantly advance the future of automotive safety. The system's ability to adjust to different passenger needs, while maintaining quick responsiveness in critical situations, demonstrates its importance in enhancing vehicle safety. The combination of the ESP8266 microcontroller, LM 398N motor driver, and other key components ensures a robust and reliable safety mechanism. Further development and testing could lead to broader applications of this system, potentially benefiting a wide range of vehicles and scenarios where passenger safety is paramount. Future improvements could include refining the torque adjustment algorithm for more precise control, as well as exploring additional features that contribute to further enhancing vehicle safety. Additionally, as IoT technology continues to evolve, there may be opportunities to integrate more advanced monitoring and control systems to ensure that vehicle safety mechanisms are both adaptive and responsive to real-time conditions.
DETECTING SIDE EFFECTS OF ADVERSE DRUG REACTIONS THROUGH DRUG-DRUG INTERACTIONS USING GRAPH NEURAL NETWORKS AND SELFSUPERVISED LEARNING
Authors: B. VASANTHA  , B. RAKSHITHA  , B. ANKITHA  , MEGHANA D. SIRI , G. NIKITHA
Published: December 2024

Adverse Drug Reactions(ADRs) due to drug-drug interactions present a public health problem worldwide that deserves attention due to its impact on mortality, morbidity, and healthcare costs. There have been major challenges in healthcare with the everincreasing complexity of therapeutics and an aging population in many regions. At present, no standard method to detect such adverse drug reactions exists until otherwise reported by patients after the drug is released to the market. Further, several studies show that it is extremely challenging to detect these rare cases during clinical trials held before the drug is released. Therefore, a reliable and efficient technique to predict such side effects before the release of the drug to the market is the need of the hour. Through the power of Graph Neural Networks and the knowledge representation abilities of self-supervised learning, we designed an effective framework to model drug-drug interactions by leveraging the spatial and physical properties of drugs by representing them as molecular graphs. Through this approach, we developed a technique that resembles the dynamics of a chemical interaction. On training and testing this approach on the TwoSIDES Polypharmacy Dataset by Therapeutic Data Commons(TDC), we achieve a state of the art results by obtaining a precision of 75% and an accuracy of 90% on the test dataset. Further, we also perform a case study on the DrugBank dataset and compare our results on the interaction type prediction task to validate our approach on the drug-drug interaction domain and achieve excellent results with precision, F1, and accuracy of 99%. Our study and experimental approaches lay the groundwork for further research on side-effect prediction through drug-drug interaction and the use of Graph Neural Networks in the field of Molecular Biology.
Review of the “2023 international symposium on global art market research”
Authors: Liu Zhenling
Published: December 2024

The 2023 International Symposium on Global Art Market Research aimed to spark a renewed conversation about global art market research in the post-pandemic era. The event featured both cross-disciplinary and multi-disciplinary approaches to the study of international art markets, focusing on the theme of “re-globalization.” Scholars from around the world presented analyses of regional dynamics from a global perspective, highlighting the connections and divisions within the global art market, and exploring the construction and mobility of art market centers and non-centers. In the context of globalization and plurality, the research presented by several scholars reflects a concern for the identity of the participants in the market, demonstrating both cooperation and confrontation in the process of art market globalization. The symposium also advocated for the application of emerging tools and interdisciplinary research methods within the art market research paradigm. The topics covered during the event reflect the comprehensive nature of art market research, offering valuable insights and methodologies for advancing the field.
Unusual coexistence of congenitally corrected transposition of great arteries with type A interrupted aortic arch: A case report
Authors: Elhelw Eslam , Hussein Amira , Shalaby Hend , Abdelmoneim Ibrahim Tharwat , Hesham Gasser , Sabri Rami Ahmed
Published: December 2024

Congenitally corrected transposition of the great arteries (CCTGA) accounts for <1% of all cases of congenital heart defect, a pathological condition characterized by the existence of both ventriculoarterial and atrioventricular (AV) discordance in the heart. CCTGA is more commonly associated with type B interrupted aortic arch (IAA) than type A variant. This is a more intricate and unusual presentation than dextro-transposition of the major arteries with an IAA. Herein, we present a case of an extraordinarily rare congenital cardiac complex defect. CCTGA and type A IAA were found in a 34-week preterm infant weighing 2.4 kg at delivery. Antenatally, the fetal echocardiogram suggested CCTGA in the form of an apically displaced left AV valve ventricular septal defect and transposed great arteries. The pulmonary trunk appeared larger than the aorta with three abnormal vessels. This study emphasizes the usefulness of sequential imaging modalities including fetal echocardiography to determine the majority of the anatomic details.
Congenital myopathy-1B caused by a homozygous RYR1 variant: A case report
Authors: Bilgeç Nagehan , Eravcı Saliha Yavuz , Güven Ahmet Sami , Çaksen Hüseyin
Published: December 2024

Congenital myopathies are a group of clinically and genetically diverse neuromuscular diseases that often present with stable and/or slowly progressive trunk and proximal weakness. Genetic analysis can help diagnose each congenital myopathy more accurately. Although an increasing number of other causative genes have been reported, ryanodine receptor 1 (RYR1)-related myopathy is the most common cause. Herein, we report the clinical presentation of a patient with congenital myopathy-1B (multiminicore disease) that was caused by a c.115 G>A homozygous variant of RYR1. The patient had normal cognitive abilities but was developmentally delayed and unable to walk. Electromyography revealed myogenic changes. The c.115G>A variant located in the second exon of RYR1 was found to be homozygous in the congenital neuromuscular gene panel. The patient’s parents and sister both carried the heterozygous variant. Clinical differences between family members with the homozygous and heterozygous variants of RYR1 highlight the correlation between the genotype and phenotype.
Capability of questionnaires to screen for sleep apnea in patients with tachyarrhythmias
Authors: Weissman Yuliya Dmitrievna , Baymukanov Azamat Maratovich , Bulavina Irina Andreevna , Yunayeva Maria Vladimirovna , Evmenenko Artem Anatolievich , Ilyich Ilya Leonidovich , Termosesov Sergey Arturovich
Published: December 2024

Early screening for sleep apnea in patients with tachyarrhythmia is particularly relevant for managing their treatment. Herein, we aimed to assess the screening capabilities of the Berlin Questionnaire, STOP-BANG Sleep Apnea Risk Scale, and Epworth Sleepiness Scale in patients with atrial fibrillation (AF) and atrial flutter. This study included 207 patients with tachyarrhythmia. The patients were asked to fill the three questionnaires. Respiratory monitoring was performed, and the cohort was divided into two groups: those with sleep apnea (Group I) and those without sleep apnea (Group II). Sleep apnea was identified in 155 patients. The remaining 52 patients did not have sleep apnea. Patients in Group I were older (64 vs. 57 years; P = 0.001) and had a higher body mass index (34 vs. 31.65 kg/m²; P = 0.027), waist circumference (114 vs. 108 cm; P = 0.001), and neck circumference (43 cm vs. 41 cm; P = 0.001) than patients in Group II. Type-2 diabetes (59 vs. 8; P = 0.004), heart failure (OR 0.797 [95% CI:0.683–0.929]; P = 0.004), and AF (OR 1.252 [95% CI:1.088–1.441]; P = 0.013) were more common in Group I than in Group II. Eighty-seven patients exhibited paroxysmal AF. The Berlin (area under the curve [AUC] 0.709; sensitivity 80%; specificity 54%) and STOP-BANG (AUC 0.708; sensitivity 79%; specificity 46%) Questionnaires effectively identified sleep apnea. The Epworth Sleepiness Scale had a low predictive ability for sleep apnea (sensitivity 15%; specificity 87%; AUC 0.543). Thus, the Berlin Questionnaire and STOP-BANG Scale may be used to assess the risk of sleep apnea in patients with AF.
Planning and performing image-assisted robotic interventions using personalized, minimally invasive, safe, and precise therapeutics
Authors: Razek Adel
Published: December 2024

This review aims to analyze complex medical interventions planned and performed using image-guided robots. Such interventions, which may involve surgical or targeted drug delivery, are minimally invasive, precise, and safe therapies. The accuracy of robotic positioning is improved by reducing uncertainty and complexity, which can be achieved by matching real and virtual interventional procedures involving physical and virtual phantoms of the relevant part of the corresponding living tissues. Such tailored training includes personalized, patient, and interventional tool characteristics, and the results enable a real (with patient) intervention controlled by staff and a possible matched autonomous intervention under staff supervision. This paper discusses considerations for selecting appropriate scanners to control and monitor image-guided interventional procedures, planning personalized medical interventions using physical and virtual phantoms, involving staff in the loop, and employing augmented matched digital twins (DTs) for real interventions. Moreover, the paper positions the image-assisted robotic strategy in comparison to laparoscopic surgery. Each topic covered in this article, while self-contained, is supported by examples from the literature to facilitate a deeper understanding. The outcomes of this review highlight the importance of complex medical interventions involving image-assisted robotics or laparoscopic processes involving minimally invasive, nonionizing, and precise interventions. Furthermore, DTs already integrated into healthcare, combined with digital tools, could offer an effective solution for managing image-assisted robotics. This includes planning interventions with phantoms or patients and involving staff in the loop.
Navigating glioblastoma therapy: A narrative review of emerging immunotherapeutics and small-molecule inhibitors
Authors: A. Abikenari Matthew , Enayati Iman , M. Fountain Daniel , Isabel Leite Maria
Published: December 2024

Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system (CNS), accounting for the majority of brain tissue tumors and CNS neoplasms. GBM has an incidence rate of 3.2/100,000 people in the United States, with an abysmal survival rate of 15 months with treatment and under 3 months for untreated patients. GBM remains incurable, with no disease-modifying treatment available. As a grade IV astrocytoma, GBM is highly aggressive, characterized by rapid proliferation, high metabolic demands, substantial angiogenesis, and diffuse infiltration of healthy parenchyma. The GBM genome is highly heterogeneous, with unpredictable amplification patterns, dysregulation, and mutational activation of receptor tyrosine kinase genes, tumor suppressor genes, and growth factor signaling. GBM’s indistinct tumor margins, its highly adaptive interaction with the brain microenvironment, and the existence of the blood-brain barrier and the blood-brain tumor barrier further limit effective anti-GBM therapeutic strategies. Hence, anti-GBM drug discoveries and molecular techniques that aim for patient-specific treatment stratification are of profound clinical and therapeutic significance. The current paper aims to outline the fundamental pathophysiology, tumorigenicity, and immunosuppressive mechanism of GBMs, review current treatment options for GBMs, and examine the contemporary challenges and advances in anti-GBM drug discovery and delivery. Finally, the paper aims to shed light on the emergence of small-molecule inhibitors, immune checkpoint inhibitors, and vaccination therapy as potentially efficacious therapeutic strategies for treating GBM.
İNVA PROQRAM TƏMINATINDAN ISTIFADƏ ETMƏKLƏ KABEL XƏTLƏRİNİN TEXNİKİ VƏZİYYƏTİNİN KOMPLEKS MONİTORİNQ SİSTEMİ
Authors: İlham Rəhimli, Əliəşrəf Bəxtiyarov İlham Rəhimli, Əliəşrəf Bəxtiyarov
Published: December 2024

Bu məqalə iNVA proqram təminatının tətbiqi əsasında enerji avadanlıqlarının texniki vəziyyətinin izlənməsi üçün kompleks monitorinq sisteminin inkişafını ətraflı şəkildə təqdim edir. Təklif olunan sistemin əsas elementləri – məlumat bazasının strukturu, diaqnostika modulu, və ekspert alt sistemləri – geniş şəkildə araşdırılır. Bu elementlərin qarşılıqlı fəaliyyəti, texniki məlumatların səmərəli emalını və nəticə etibarilə avadanlıqların vəziyyəti ilə bağlı etibarlı qənaətlərin formalaşdırılmasını təmin edir. Xüsusi olaraq, kabel xətlərinin texniki vəziyyətini qiymətləndirmək üçün işlənib hazırlanan diaqnostik modellərin və onların əsasında qərar qəbuletmə alqoritminin təfərrüatları verilir.
Bundan əlavə, məqalədə istismar və diaqnostik parametrlərin təsnifatı sistematik şəkildə təqdim olunur. Bu parametrlərin düzgün təhlili və inteqrasiyası texniki vəziyyətin proqnozlaşdırılması prosesində mühüm rol oynayır. Belə yanaşma yalnız mövcud qüsurları müəyyən etmək deyil, həm də gələcəkdə avadanlıqda yarana biləcək nasazlıqları qabaqcadan aşkar etmək və planlı təmir işlərini optimallaşdırmaq məqsədini güdür. Yüksək gərginlikli avadanlıqların diaqnostikasına kompleks yanaşma – bir neçə parametrin birgə təhlili və sensorlardan alınan məlumatların inteqrasiyası – bu cür avadanlıqların təhlükəsizliyinin və davamlı istismarının təmin olunması baxımından əhəmiyyətli hesab olunur.
Bununla yanaşı, məqalədə müxtəlif diaqnostika və proqnozlaşdırma metodlarının texniki vəziyyətin qiymətləndirilməsində və enerji avadanlıqlarının xidmət müddətinin uzadılmasında effektiv tətbiqi göstərilir. İnteqrasiya olunmuş məlumat bazası və ekspert sistemləri, texniki xidmət göstəricilərinin dəqiqliklə analiz edilməsi və nasazlıqların erkən mərhələdə aşkarlanması imkanını artıraraq, diaqnostika prosesinin keyfiyyətini artırır.
Açar sözlər: iNVA proqram təminatı, Kabel xətlərinin monitorinqi, Enerji avadanlıqlarının diaqnostikası, Kompleks monitorinq sistemi.
КРИТЕРИИ ОЦЕНКИ ЭФФЕКТИВНОСТИ ИННОВАЦИОННОЙ ДЕЯТЕЛЬНОСТИ ПРЕДПРИЯТИЙ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: Натаван Ибрагимова, Туран Бахышев Натаван Ибрагимова, Туран Бахышев
Published: December 2024

В условиях современного рынка инновационная деятельность организаций становится ключевым фактором их конкурентоспособности и устойчивого развития. Цель данного исследования заключается в совершенствовании методик анализа эффективности инновационной деятельности организаций, что способствует более глубокому пониманию ее влияния на финансовые и экономические результаты.
В работе предложен комплекс экономических показателей, которые позволяют оценить рыночную привлекательность инновационных идей и готовность предприятий к их внедрению. Эти показатели служат инструментом для анализа финансово-экономических перспектив компаний, а также для прогнозирования потенциала инновационных продуктов на рынке. Ключевыми аспектами оценки являются не только потенциальная доходность, но и риски, связанные с внедрением новых технологий.
Также в статье разработаны методики, которые позволяют оценить влияние инноваций на хозяйственную деятельность организаций. Эти методики позволяют рассчитать темпы роста основных экономических показателей, таких как выручка, прибыль, рентабельность и другие, что дает возможность руководству принимать обоснованные решения в области инвестирования в инновации.
В заключительной части статьи акцентируется внимание на важности учета коммерческой и внутрифирменной эффективности инвестирования проектов. Это стало возможным благодаря разработанному механизму комплексной оценки внедрения инноваций на предприятии. Данный механизм позволяет не только оценить коммерческую эффективность внедрения инноваций, но и исследовать влияние новых технологий на внутрифирменные результаты, такие как производительность труда, организационные процессы и качество управления.
Таким образом, предложенные методики и механизмы анализа создают условия для более целенаправленного и обоснованного инвестирования в инновационные проекты, что в свою очередь способствует повышению конкурентоспособности организаций и их устойчивому развитию на рынке.
Ключевые слова: инновация, критерии эффективности инноваций, эффективность деятельности предприятия, оценка инноваций, современная бизнес-среда.
BİOLOJİ TOXUMALARIN İMPEDANSININ ÖLÇMƏ SİSTEMİ
Authors: Akif Xıdırov, Nərmin Qədirova Akif Xıdırov, Nərmin Qədirova
Published: December 2024

Bioloji toxumaların impedansının dəqiq ölçülməsi bir çox biotibbi tətbiqlərdə, o cümlədən toxumaların xassələrinin öyrənilməsində, diaqnostikasında və tibbi cihazların kalibrlənməsində çox vacibdir. Ənənəvi impedans ölçmə üsulları çox vaxt küy və maneələr, elektrodların polyarizasiyası və ətraf mühitin təsirləri səbəbindən qeyri-dəqiqliyə məruz qalır. Məqalədə bioloji toxumaların impedansını yüksək dəqiqliklə ölçmək üçün təkmilləşdirilmiş sistem təqdim olunur. Sistem LabVİEW və MATLAB mühitlərində simulyasiya edilmiş, bioloji toxumaların impedansının Cole modelinin informativ parametrləri qiymətləndirilmişdir. Sistem yüksək dəqiqlikli siqnal generasiyasını, adaptiv filtrasiyanı və ölçmə artefaktlarının real vaxt rejimində korreksiyasını özündə birləşdirir. Alınmış nəticələr bioloji toxumaların impedansının ölçmə dəqiqliyinin artdığını nümayiş etdirir. Bu da təqdim edilən xarakteristikalara malik sistemlərin klinik və biotibbi tədqiqatlar üçün tətbiqinin effektiv ola biləcəyini vəd edir.
Açar sözlər: İmpedans, bioloji toxumalar, Elektrik İmpedans Spektroskopiyası, ekvivalent elektrik sxemi, işçi siqnalın generasiyası
CƏNUB QAZ DƏHLİZİNİN CARİ VƏZİYYƏTİ VƏ İNKİŞAFI PERSPEKTİVLƏRİNİN ANALİTİK TƏHLİLİ
Authors: Ramiz İsmayılov, Türkan Guliyeva Ramiz İsmayılov, Türkan Guliyeva
Published: December 2024

Hal-hazırda Azərbaycan Avropanın qaza olan tələbatının Rusiyadan asılılığını aşağı salınması və qaz kəmərləri marşrutlarının diversifikasıyası baxımından mühüm yer tutur. Ölkənin qaz ehtiyatlarının proqnoz qiymətləri, real hasilatın həcmi və yaradılmış mövcud infrastruktur, siyasi stabillik və son illərdəki layihələrdə iştirakı, onu etibarlı tərəfdaş kimi göstərmiş və bir mənalı qəbul olunmuşdur.
Təbii qazın Avropaya çatdırilması Cənub Qaz Dəhlizi vasitəsilə həyata keçirilir və bu məqalədə həmin dəhlizin çari fəaliyyəti və perspektiv inkişafı istiqamətləri təhlil olunmuşdur. Təhlil etibarlı mənbələrə istinad edən məlumatlar əsasında aparılmış, hasilatın, daxili tələbatın və ixrac olunan qazın həcmlərin dinamikası təhlil olunmuş və yaxın illər üçün müvafiq proqnoz qiymətlər alınmışdır. Aparılmış tədqiqatların nəticələri əsasında müəyyən olunmuşdur ki, “Şah Dəniz Faza-2” layihəsi üzrə işlərin tamamlanması, perspektiv “Abşeron yatağının” hasilata daxil olunması və Tükmənistan qazının Cənub Qaz Dəhlizi ilə nəql olunması perspektivi, Avropaya ixrac oluna biləcək təbii qazın həcminin xeyli artırılması real görünür və aparılan hesablamalarla təsdiqlənir.
Açar sözlər: Cənub Qaz Dəhlizi, təbii qaz, təchizat zənciri, boru kəmərləri, ötürmə qabiliyyəti, proqnozlaşdırma.