bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacoeconomic evaluation of using enzalutamide for treatment of patients with metastatic hormone-sensitive prostate cancer
Authors: Avxentyev N. A. , Derkach E. V. , Makarova Yu. V.
Published: May 2022

Background. The addition of enzalutamide to standard androgen deprivation therapy (ADT) significantly increases overall survival and progression-free survival in patients with metastatic hormone-sensitive prostate cancer (mHSPC) compared with ADT.

Objective: to evaluate the incremental cost/effectiveness ratio (ICER) of enzalutamide use in patients with mHSPC and the ICER of enzalutamide as the first-line therapy for metastatic castration-resistant prostate cancer (mCRPC) from the Russian healthcare system perspective and to assess the contribution of enzalutamide into the reduction of mortality of mHSPC patients in the Russian Federation on the horizon until 2024.

Materials and methods. Standard ADT regimens for mHSPC were used as a comparator as it is the most common treatment for mHSPC in Russia. We proposed a Markov model of mHSPC progression on enzalutamide + ADT (hereinafter enzalutamide) or ADT + 1st generation antiandrogen (hereinafter ADT) based on ENZAMET trial data. Model was used to calculate the average life-years gained (LYG) and costs of mHSPC and post-progression mCRPC treatment. Simulation period was 15 years with one cycle of 1 month. In the “cost–effectiveness” analysis, we calculated enzalutamide ICER compared to ADT. In addition, we calculated ICER for enzalutamide plus ADT vs ADT in the first-line therapy of mCRPC as a benchmark based on PREVAIL trial data. In both cases, the average LYG over a 15-year period was used as an efficacy criteria. To assess the contribution of the enzalutamide into the reduction of mortality rate of mHSPC patients, the potential number of patients who could be treated with enzalutamide on the horizon of 2021–2024 was taken into account.

Results. According to the Markov model, the average LYG over a period of 15 years for enzalutamide was 7.59 years compared to 5.12 for ADT. The average enzalutamide therapy costs were 11,193,802 rubles per patient for 15 years, which were 8,597,131 rubles higher than when using ADT (2,596,672 rubles). ICER for enzalutamide (vs ADT) in mHSPC treatment was 3,484,362 rubles per one life-year gained. ICER for enzalutamide in the first line of mCRPC treatment (vs ADT) was 5,899,418 rubles per one life-year gained. The combination therapy with enzalutamide + ADT in Russia can be started annually by 2,410 mHSPC patients. If they all receive enzalutamide a total of 561 averted deaths among prostate cancer patients can be expected in 2021–2024.

Conclusion. In the Russian healthcare system, ICER for enzalutamide in mHSPC was 3,484,362 rubles and the ICER for enzalutamide in mCRPC was 5,899,418 rubles. Enzalutamide can make a significant contribution to achieving the target cancer mortality rates by 2024.
THE PLACE OF ECONOMIC SYSTEM IN SOCIETY: KARL POLANYI’S SOCIETAL APPROACH AS AN ALTERNATIVE TO MARKET FUNDAMENTALISM
Authors:   Taras Shevchenko National University of Kyiv, Nazarov I.
Published: May 2022

This article based on the works of Karl Polanyi (1886-1964), the famous American and Canadian economist, one of the founders of economic anthropology, explores two conceptual approaches to identifying the place of economy in society – societal and economistic. The article examines the substantive definition of economics (as an institutionally formalized process of interaction between man and the environment aimed at satisfying needs) given by K. Polanyi, as opposed to its formal definition by representatives of neoclassical economics (as a process of satisfying needs by choosing alternative options for managing scarce resources). It analyses the core idea of K. Polanyi’s societal approach, i.e. the idea of “embeddedness” of the economy into society as a more complex and polystructural system, that gives economic processes different institutional forms for different societies. The article exposes the fundamental nature of the economistic approach implying a separation of the economy from a set of social ties into a separate sphere, operating according to its autonomous laws. This approach, typical for market fundamentalists, results in the inevitability of submission of all social life spheres to the logic of price forming markets. The author considers Polanyi’s arguments against the economistic approach, which (just like the formal definition of economics), in his opinion, is applicable only for a short historical period of the formation of the industrial system, when the main factors of production – labor and land – become goods and their flow is subject to the market laws not being mitigated by any social “shock absorbers”. This situation threatens with serious social cataclysms and to avoid them the society, in the next stages of its development, blocks the effects of spontaneous market forces by the means of social and labor legislation, strong trade unions, state regulation of money-and-credit relations, and the land market, environmental legislation and other institutional regulators.
METHODOLOGICAL TOOLSET FOR ASSESSING THE LEVEL OF EMPLOYEES’ LOYALTY TO COMPANY’S HR-BRAND
Authors:   Taras Shevchenko National University of Kyiv, Firsova S. , Bilorus T. ,   Taras Shevchenko National University of Kyiv
Published: May 2022

In this paper currently important issues of HR-brand management have been examined. The necessity of developing methodological tools for assessing the level of loyalty of the company’s employees to the internal HR-brand as a system-forming component of effective management of the company-employer in modern business conditions is proved. The article focuses on the essence of the category “employee loyalty to the HR-brand of the company”, which is proposed to understand the level of intangible behavior of employees of the company, which is accompanied by emotional attachment to it. This made it possible to distinguish two components of loyalty – behavioral and emotional. A system for assessing the level of employee satisfaction with the company’s HR brand has been developed by surveying the company’s employees using the method of semantic differential. To substantiate the level of “behavioral loyalty of the employee to the HR-brand of the company”, the use of indicators is proposed: the number of times the employee changes during his work; the number of times an employee has changed jobs in the last five years; work experience in the analyzed company. The level of “emotional loyalty of the employee to the HR-brand of the company” equally depends on the degree of awareness of the employee about the company’s activities; the level of employee satisfaction with the system of motivation and stimulation of work; the level of employee satisfaction with the system of relations in the team; the level of employee satisfaction with the personnel management system; the employee’s intentions to recommend the company as a potential job. It is proposed to distinguish the levels of employee loyalty to the HR brand of the company: absolute, hidden, false and lack of employee loyalty. The grouping of respondents according to the results of the survey allows to determine the structure of employees by the level of loyalty to the HR-brand of the company. The study proposes the separation of four threshold intervals of a comprehensive indicator of employee loyalty to the HR-brand of the company with a gradation to low, satisfactory, high and high. The obtained results allow mathematically formalize the definition of the degree of employee loyalty and to develop a clear program of actions to standardize employee satisfaction and justify management decisions to optimize the development of their HR-brand. The proposed methodological approach can be used by managers of employers to develop and justify strategic management decisions to optimize their development in general and the personnel component in particular.
Topical Issues of Expert Identification in the Forensic Authorship Studies
Authors: Sokolova T. P.
Published: May 2022

Within the school of forensic expertology, in the context of modern challenges of digitalization, the current problems of forensic and expert identification are considered to establish the author of a controversial speech work posted on the Internet, an information and media language personality. Based on the analysis of the main stages of the process of expert identification of the author of the text, the need for their correction and addition is revealed in connection with significant changes in the linguistic personality manifests itself mainly in a virtual environment. The necessity of developing a classifier of the author’s idiolect features with an indication of their identification significance, as well as the use of quantitative statistical methods for analyzing speech works using computer technology, is substantiated.
MALMI: An Automated Earthquake Detection and Location Workflow Based on Machine Learning and Waveform Migration
Authors: Shi Peidong , Grigoli Francesco , Lanza Federica , Beroza Gregory C. , Scarabello Luca , Wiemer Stefan
Published: May 2022

Robust automatic event detection and location is central to real-time earthquake monitoring. With the increase of computing power and data availability, automated workflows that utilize machine learning (ML) techniques have become increasingly popular; however, ML-based classical workflows still face challenges when applied to the analysis of microseismic data. These seismic sequences are often characterized by short interevent times and/or low signal-to-noise ratio (SNR). Full waveform methods that do not rely on phase picking and association are suitable for processing such datasets, but are computationally costly and lack clear event identification criteria, which is not ideal for real-time processing. To leverage the advantages of both the methods, we propose a new workflow—MAchine Learning aided earthquake MIgration location (MALMI), which integrates ML and waveform migration to perform automated event detection and location. The new workflow uses a pretrained ML model to generate continuous phase probabilities that are then backprojected and stacked to locate seismic sources using migration. We applied the workflow to one month of continuous data collected in the Hengill geothermal area of Iceland to monitor induced earthquakes around two geothermal production sites. With a ML model (EQ-Transformer) pretrained using a global distribution of earthquakes, the proposed workflow automatically detects and locates 250 additional seismic events (accounting for 36% events in the obtained catalog) compared to a reference catalog generated using the SeisComP software. Most of the new events are microseismic events with a magnitude less than 0. Visual inspection of the waveforms of the newly detected events indicates that they are real seismic events of low SNR and are only reliably recorded by very few stations in the array. Further comparison with the conventional migration method based on short-term average over long-term average confirms that MALMI can produce much clearer stacked images with higher resolution and reliability, especially for events with low SNR. The workflow is freely available on GitHub, providing an automated tool for simultaneous event detection and location from continuous seismic data.
Pengembangan Pembelajaran Berbasis Web Dengan Pendekatan Guided Discovery Berbantuan Hypermedia Untuk Siswa SMP
Authors: Abdurrokhim Abdurrokhim , Kuswandi Dedi , Ulfa Saida
Published: May 2022

The purpose of this study was to produce web-based learning using a hypermedia assisted discovery guided approach for junior high school students. The development model applied in this study is the ASSURE model. The development stage begins with analyzing the characteristics of students, then stating the learning objectives. The next stage is selecting strategies, technology, media and materials to support the achievement of predetermined learning objectives, then utilizing technology, media and materials, ensuring student participation, and the final stage is conducting evaluation and revision. The result of the development is in the form of a learning web whose activities use the guided discovery procedure and the content is presented using the hypermedia principle. Based on the results of observations, students looked excited and they were actively involved during the learning process. Students say that learning becomes more flexible because they can adjust to the time they have. Based on the response analysis, it was found that the average student gave a positive response. So it can be concluded that web-based learning with the guided discovery approach assisted by hypermedia can improve the quality of learning in junior high schools, especially in terms of student participation in learning, enthusiasm and learning flexibility
Takotsubo stress cardiomyopathy, a great mimicker of myocardial infarction in post-operative period: what surgeons should know? a case series
Authors: . Soundappan , . Swaminathan , Vijai Anand , Kumar Prashanth Ashok , John Joseph , Harsha Muvva Sri , Gajdhar Aniq Ur Rehman
Published: May 2022

Takotsubo stress cardiomyopathy (TCM) is a rare disorder of the myocardium precipitated mainly by physical, mental stress or sometimes due to non-specific factors. The clinical presentation of takotsubo cardiomyopathy is an eidetic image of CAD and myocardial infarction (MI), but unlike the later takotsubo cardiomyopathy in most cases is reversible. Coronary angiographic evidence showing the absence of narrowing of coronary vessels is the only definitive way to distinguish this from MI. This condition is a less familiar entity to the surgeons and knowing this will help in arriving at the diagnosis early and have an optimistic attitude towards management because the condition is a self-limiting and good recovery is seen generally with supportive management. In this series, 1056 HPB cases and 101 liver transplant cases done from January 2016 to February 2021 and among them we describe four cases who developed TCM in post-operative period and discuss the relevant literature.
On the concept of sustainability and future generations. A brief constitutional overview
Authors: Porena Daniele
Published: May 2022

O princípio da sustentabilidade nasceu na elaboração do direito ambiental internacional e imediatamente assumiu um significado intergeracional.Inicialmente, o conceito de sustentabilidade foi percebido principalmente como um princípio ético: ao longo do tempo, graças às progressivas codificações que o envolveram, e também às elaborações oferecidas pela teoria da justiça, ele amadureceu uma consistência autenticamente jurídica.Hoje o princípio da sustentabilidade vive uma fase de progressiva emancipação apenas do perímetro do direito ambiental.Em particular, o princípio da sustentabilidade é cada vez mais chamado para estimular a construção e operação de todos os aparatos públicos dentro dos quais as escolhas sistêmicas são feitas pelas diferentes comunidades.
A Comfort or a Threat? How Older Italians View Home Eldercare Assistants
Authors: Barrett Anne E. , Vecchione Katia
Published: May 2022

Increasing life expectancy has led, in many countries, to new arrangements to meet the growing need for care in later life. In Italy, with the second oldest population in the world, family members, especially women, provide the majority of care. Paid care workers, however, are increasingly filling in where families cannot. Known as “home eldercare assistants” or badanti, most are middle‐aged women from Eastern Europe, South America, or the Philippines. Research on this phenomenon is limited by its almost exclusive focus on care workers rather than older adults who receive their care —or may do so in the future. Our study addresses this issue using interviews with 28 older adults living in northern Italy. Participants with friends or family members who had received support from these care workers often held positive views. Most, however, also expressed negative views that resonated with cultural discourses about aging, as well as immigration. These views reflected the high value placed on independence, along with the centrality of the home as a site for decision‐making and identity maintenance. Negative views also were shaped by dominant discourses that construct immigrants as threats to security, particularly regarding one's belongings. Another discourse that influenced views of home eldercare assistants centered on the construction of aging as a biomedical phenomenon that is better addressed by medical professionals in health care settings, including nursing homes. Such views influence older adults' willingness to receive help from care workers and its effectiveness—knowledge of which can improve care.
Anchored Yet Displaced: Affordable Housing and Aging in a Gentrifying Place
Authors: Sweeney Brian N.
Published: May 2022

In an era of urban gentrification and rising economic inequality, how can policies better address the needs of older city residents who wish to age in place? Drawing on qualitative data from in‐depth interviews and participant observation, as well as US census data from 2010 to 2020, this study explores the perceptions and experiences of older adult residents of two affordable housing complexes in the Manhattan borough of New York City. These residents have aged in place while their surrounding community has grown wealthier and, in some respects, younger. While benefiting from housing security and numerous on‐site services targeting the aged‐in population, the residents nonetheless experience feelings of alienation and estrangement as their surrounding community undergoes physical, social, and cultural changes. This paper theorizes aging in place as an ongoing process of social integration and meaning making to explore issues of identity, housing, and community and to consider how policy can better address the needs of older adults aging within rapidly gentrifying urban contexts.
All life is in science
Authors: Pyshnaya O. N. , Gurkina L. K. , Pinchuk E. V.
Published: May 2022

The article describes the life and creative path of the famous scientist, a prominent specialist in the field of ecology, breeding and seed production of vegetable crops, аcademician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, laureate of the State Prize and the Prizes of the Government of the Russian Federation Viktor Fedorovich Pivovarov.
Study of an Immersed Axisymmetric Turbulent Jet in Comparative Analysis of Turbulence Models
Authors: Malikov Z.M. , Nazarov F.Kh.
Published: May 2022

The study comparatively analyzes RANS turbulence models, such as the Menter (SST), Spalart --- Allmaras (SA), Sekundov models, and a recently developed two-fluid model by numerical simulation of an axisymmetric immersed jet. The analysis is done by comparing the obtained numerical results with experimental data and using the results of the analysis of their numerical implementation. For all models, the same numerical algorithm is applied. To facilitate the study of a free jet, "parabolized" hydrodynamic equations are considered, for the numerical implementation of which the marching integration method is used. An absolutely stable implicit finite-difference scheme is applied. The study shows that the developed two-fluid model has advantages over other models both in terms of accuracy and simplicity of numerical implementation
Variational Formulation of the Mathematical Model of Stationary Heat Conduction with Account for Spatial Nonlocality
Authors: Savelyeva I.Yu.
Published: May 2022

In creating and using new structurally sensitive materials, it is essential to construct mathematical models which make it possible to describe the materials’ behavior in widely changing external influences. Modeling of non-local media is a class of methods of generalized continuum mechanics. The capability of analyzing mathematical models of a continuous medium can be extended through variational methods. The paper describes the construction of a functional for the problem of stationary heat conduction in a homogeneous body, taking into account the effects of nonlocality and with a temperature-independent heat conduction coefficient. A variational formulation used in the case of a linear problem in combination with acceptable admissible functions allowed us to quantify this effect. The study gives an example of using the variational formulation, which takes into account the influence of the spatial nonlocality of the stationary heat conduction process on the parameters that determine the well-known phenomenon of thermal explosion with an exponential temperature dependence of the volumetric heat release rate in the plate. The quantitative analysis was carried out for two versions of the function that is admissible for the constructed integral functional and describes the possible temperature distribution over the thickness of the plate under consideration. Having compared the obtained results, we opted for the admissible function, as its use leads to a smaller difference between the maximum value of the parameter characterizing the intensity of heat release in the plate and the known result found with no account for the influence of spatial nonlocality
Effect of Water Hyacinth (Eichhornia crassipes) Infestation on Selected Surface Water Quality Parameters
Authors: Asmath A.M.M. , Begum Sulaima Lebbe Rasmiya , Shama Latheef Fathima Zisath
Published: May 2022

Background: Infestation of aquatic weeds indicates surface water pollution, thus questioning its potential use. The present study was aimed to investigate the effect of water hyacinth infestation in surface water in terms of surface cover and morphological characteristics. Methods: Surface water samples at a depth of less than 30 cm were collected from water hyacinth covered and uncovered sites and analyzed for water quality parameters such pH, TSS, DO, turbidity and EC. Water hyacinth plants were also collected using a 1 m2 quadrate to investigate the relationship between water quality and weed morphological characters. Result: The water quality was comparatively low at water hyacinth covered sites than uncovered sites for pH (7.09-7.89), TSS (0.5-1.86), DO (4.15-6.08), turbidity (5.57-25.9) and EC (91-748). Amongst, TSS (p less than 0.05) only showed a significant difference. Hence, morphological characters, leaf length and width were significantly and positively (0.956) correlated to each other. Further turbidity and EC respectively showed positive and negative correlation to leaf length (r=0.219, r=-0.290) and leaf width (r=0.194, r=-0.257). Though water hyacinth infestation lowered the water quality, the values were within the tolerance limits for standard surface water. Therefore, the present study concluded that water hyacinth infestation did not degrade the surface water quality intensively and the surface water could be utilized for aquaculture, agriculture or recreational purposes with or without minimal treatment.
Effects of Binders on Physico-chemical Characteristics of Egg Albumen Paneer (EAP)
Authors: Thakuria Kushal J. , Nath Dilip R. , Das Ankur , Hazarika Mineswar , Laskar Saurabh Kumar , Saikia Rashmi R. , Choudhury Sadhana
Published: May 2022

Background: An innovative food product from egg albumen analogous to the conventional paneer was developed by inclusion of different types of binders and their effects on the physico-chemical qualities of the product were studied. Methods: Different cereal flours were used as binders viz., juoha rice flour (JRF), glutinous rice flour (GRF), wheat flour (WF) and oat flour (OF) in different ratios, with the egg albumen as the base material for the production of egg albumen paneer (EAP). EAP cubes were packed in food grade high density polyethylene bags and stored at 5-7oC for physico-chemical evaluation upto 90 days. Rehydration properties of the dried products were also studied. Result: Studies of EAP revealed that pH and water activity differ significant (P less than 0.01) among the treatments groups and decreased gradually during storage irrespective of the treatment groups and days of storage. The Thiobarbituric acid and Tyrosine values also showed significant (P less than 0.01) differences among the treatment formulations as well as during the storage days. The rehydration percentage, increase in volume after rehydration and coefficient of rehydration recorded highest in T1 than the other samples. Both the rehydration ratio and rehydration percentage were recorded highest in T2 group.
Influence of Differential Substitution of Nutrients through Organics on Growth, Yield and Nutrient Content of Green Gram (Vigna radiata) in Irrigated Sub-tropical Region of J and K
Authors: Banotra Monika , Sharma B.C. , Kumar Rakesh , Mahajan Amit
Published: May 2022

Background: Green gram is the important pulse crop of India and grown under extensive agroclimatic condition in India for its versatile uses. Moreover, extreme and inappropriate use of inorganic nutrients deteriorated the soil quality by reducing the soil microbial population and also declined the quality of crops. Now a days, majority of population living in urban and rural area had demand for safe and healthy food for which inclusive food production technology needs to be developed with priority on quality enhancement and yield stability. In fact, it is not possible for farmers to directly shift from inorganic source of nutrients to organics in their crop production as it may lead to decrease in crop yields in the initial years. This may be possible due to substitution of organic sources of nutrients in place of inorganics to fulfil the crop nutrient requirement for accomplishing higher and stable crop yield of better quality with upgradation in soil health. Therefore, the present study was carried out to evaluate the influence of differential substitution of nutrients through organics on growth, yield and nutrient content of green gram (Vigna radiata) in irrigated sub-tropical region of J and K. Methods: The experiment was conducted for two consecutive years in field during summer 2016 and 2017 at research farm of division of Agronomy located at latitude and longitude of 32°40' N and 73°64' E at Skuast-Jammu. Experiment was laid out with 16 treatments and three replications. Green gram variety “SML-668” was grown as per their respective recommended packages of cultivation except for the nutrient-N and its organic sources which were applied as per the treatments. Nutrient content of green gram was worked out in the laboratory following standard procedures. Result: The pooled result of the two-year study of green gram concluded that significantly highest growth parameters and yield of green gram were recorded with treatment 100% recommended dose of fertilizer whereas significantly lowest value of all these parameters were recorded with treatment 100% NPK through FYM. Numerically highest value of NPK content in seed and stover of green gram after two-year experiment was recorded with treatment 100% NPK through FYM whereas highest gross returns, net returns and b:c ratio were recorded with treatment 100% recommended dose of fertilizer when compared with other treatments.
Sindemia de la “COVID-19” en el mundo
Authors: Mora-Alvarado Darner A.
Published: May 2022

Este estudio tiene como objetivo describir la evolución, captada en tiempo real, de la crisis de la “COVID-19” en los cinco continentes del mundo, mediante el uso de la bibliografía existente, considerando los casos confirmados, muertes y letalidad por el virus del “SARS-CoV-2”. Además, se determina el avance en la vacunación contra la enfermedad, además de abordar la influencia de las estaciones climáticas en la evolución de la crisis sanitaria en América Latina y Europa;  esto último, como hipótesis de estudio para futuras investigaciones de esta sindemia, en donde se evidencia la sinergia entre el agente infeccioso, las enfermedades crónicas de los afectados en medio de inequidades sociales. Los resultados obtenidos hasta el 03/12/2021, indican que el continente más impactado es el Americano, mientras que el continente más abandonado en la vacunación contra la “COVID-19” es África.
Enfoques basados en microalgas para superar los efectos de la pandemia por COVID-19
Authors: Núñez-Montero Kattia , Guerrero-Barrantes Maritza , Gómez-Espinoza Olman
Published: May 2022

A finales del 2019 un nuevo coronavirus llamado coronavirus de tipo 2 causante del síndrome respiratorio agudo severo (SARS-CoV-2) empezó a propagarse rápidamente a nivel mundial, al punto de convertirse en una pandemia para inicios del 2020. Después de casi dos años de vivir con esta nueva enfermedad, la humanidad sigue enfrentado una de sus mayores crisis, no solamente a nivel de salud, sino también ambiental y económico. Para poder alivianar algunos de los efectos sufridos mundialmente por la pandemia es necesario la integración de estrategias novedades en terapias médicas y fortalecimiento económico. Bajo este escenario, la presente revisión presenta las funcionalidades de las microalgas que podrían ser explotadas para impulsar las áreas más afectadas por la pandemia. Entre los beneficios más promisorios se destacan las diversas biomoléculas derivadas de microalgas que podrían ser terapias adyuvantes o agentes preventivos, así como su potencial para convertirse en biofábricas de anticuerpos o vacunas a través de ingeniería genética. Finalmente, el desarrollo de industrias a base de microalgas podría convertirse en un impulsor de la economía y una fuente de generación de empleos locales. De esta forma se expone el impacto positivo de los productos derivados de microalgas en ámbitos farmacológicos, ambientales e industriales que podrían explotarse para contrarrestar las consecuencias de dos años en pandemia.
Turismo post-COVID en México y el mundo
Authors: Cruz-Jiménez Olga Carolina , Montes-Ortiz Daniel , Martínez-Rodríguez María Concepción
Published: May 2022

El constante incremento de turistas que se desplazan a nivel mundial ha hecho que los gobiernos de cada país trabajen de manera permanente y cada vez más específica en materia turística, garantizando una mejor gestión de la afluencia de visitantes en los lugares, esto con el objetivo de poder controlar el uso de recursos naturales y atender las necesidades de los habitantes, pues la inminente escasez de elementos vitales para la supervivencia es un tema cada vez más delicado y de urgencia a tratar. Como parte de los proyectos para poder erradicar dicho problema y con una pandemia de por medio, diversos organismos internacionales han brindado herramientas que deben ser adecuadas a los planes de desarrollo para una mejor política pública. Dentro de los puntos a observar está la sobrecarga de capacidad turística en los lugares de interés ya que, derivado del crecimiento acelerado de habitantes en el mundo y el aumento de viajes, el límite de personas que puede estar en un mismo espacio se ha visto excedido y con ello detona el aumento de problemas a nivel local en los destinos turísticos. Por los recientes acontecimientos del virus del COVID-19, la actividad turística fue de las más afectadas. Para poder garantizar el desarrollo y resurgimiento del turismo post-pandemia, se tiene que llegar a una buena planeación con base en las nuevas exigencias de los pasajeros y locales en cuanto a la bioseguridad y confianza que cada destino turístico brinde, además de apostar por un turismo sustentable.
Decolonising Knowledge for Development in the Covid-19 Era
Authors: Taylor Peter , Tremblay Crystal
Published: May 2022

This Working Paper seeks to explore current and emerging framings of decolonising knowledge for development. It does this with the intent of helping to better understand the importance of diverse voices, knowledges, and perspectives in an emerging agenda for development research. It aims to offer conceptual ideas and practical lessons on how to engage with more diverse voices and perspectives in understanding and addressing the impacts of Covid-19. The authors situate their thoughts and reflections around experiences recently shared by participants in international dialogues that include the Covid Collective; an international network of practitioners working in development contexts; engagement and dialogue with Community-based Research Canada, and their work with the Victoria Forum. Through these stories and reflections, they bring together key themes, tensions, and insights on the decolonisation of knowledge for development in the context of the Covid-19 era as well as offering some potential ways forward for individuals and organisations to transform current knowledge inequities and power asymmetries. These pathways, among other solutions identified, call for the inclusion of those whose challenges are being addressed, reflective spaces for inclusive processes, and connection, sharing and demonstrating the value of decolonised knowledge for liberation and trust.
Populist Constitutionalism in Brazil and Peru: Historical and Contextual Issues
Authors: Mesquita Ceia Eleonora
Published: May 2022

Given populism's common practice in South America, the region provides a crucial case to identify populism as a prevalent strategy by different ideologies. The link between populism and constitutionalism is paramount because populist governments typically use constituent power and constitutional identity to reach political goals. This study aimed to provide a comparative constitutional analysis of the recent development of populism in Brazil and Peru. The first was the rhetoric and practices of Jair Bolsonaro's government in Brazil, whereas the second was Pedro Castillo's government in Peru regarding constitutional reforms and human rights issues. This comparison justified that Brazil and Peru are presidential republics where harsh political polarization shakes their societies. Bolsonaro and Castillo have anti-corruption discourses and support a new constituent process but present antagonistic economic views. This study was comparative in nature that used a qualitative approach, sourced from bibliographic and documentary research that included specialized literature on South American populism and constitutionalism and the government's plans and legislation. This study showed that both governments have difficulties executing their respective agendas on customs and constituent referendums due to governability problems and important features of the constitutional design, such as eternity clauses, judicial review, and constitutional rigidity. It concluded that the populist strategies of Bolsonaro and Castillo are different. Bolsonarism is antiliberal and promotes human rights regression, whereas Castillo's populism is conservative but democratic. In common, both face the coalitional presidentialism and constitutional protection mechanisms as constraints to putting their political goals entirely into practice.

KEYWORDS: Authoritarianism, Constitutionalism, Fundamental Rights, Populism.
Recognition of Forest Carbon Rights in Indonesia: A Constitutional Approach
Authors: Cetera Kenny
Published: May 2022

As a forest-rich nation, Indonesia has actively participated in carbon market governance like the REDD+ program. With the rapid expansion of REDD+ to address the effects of climate change, questions surrounding carbon rights have surfaced. This study aims to analyze the regulatory development of carbon rights in Indonesia and its impact on the community rights over forest resources by elaborating on the ideal carbon rights governance under a constitutional perspective. The study uses the normative method, which includes pertinent rules and supporting statements from climate change specialists. This study shows that carbon rights are defined broadly as the right to participate in forest carbon trading, although they require a government permit. There is no clear explanation of the relationship between land tenure and carbon ownership under the existing legislation, despite four permits to acquire carbon benefits: environmental service, social forestry, ecosystem restoration, and forest carbon administration permit. While the state can claim state control rights on certain commodities like carbon under Article 33 of the Indonesian Constitution, it also has to manage the distribution of carbon incentives based on the public interest. By facilitating the transfer of carbon rights under a carbon trading scheme while highlighting the government's role in sharing the benefits of carbon via a result-based payment scheme, Presidential Regulation 98/2021 contributes to more explicit control of carbon rights. All concerns related to carbon rights governance in Indonesia include complicated administrative and technical requirements for applying for a license, insecure land tenure due to overlapping claims, and unlawful encroachment in forest regions. Since land tenure issues remain unresolved, recognizing carbon rights as an alternative to recognizing marginal and community rights to forest resources could be viable.

KEYWORDS: Environmental Regulation, Forest Carbon Rights, REDD+.
Syphilitic Balanitis of Follmann
Authors: Bonito Frederico , Cerejeira Diogo , Alves João
Published: May 2022

N/a.
Die Diskussion um den konfessionell-kooperativen Religionsunterricht seit 1993 bis heute
Authors: Schröder Bernd
Published: May 2022

Der Beitrag zeichnet anhand von Archivalien das Zustandekommen konfessionell-kooperati­ven Religionsunterrichts am Beispiel des Bundeslandes Niedersachsen in der Zeit seit 1991 nach. Gerahmt wird diese Rekonstruktion einerseits von Hinweisen auf frühere Initiativen zur Einführung eines konfessionsübergrei­fenden Religionsunterrichts in der ersten Hälfte des 19. Jahrhunderts und in den 1970er-Jahren sowie andererseits von religionspädagogischen Beobachtungen zu jener Genese.
Englert, Rudolf / Eck, Sebastian (2021). R-A-D-E-V. Religionsunterrichtliche Lehrstücke im Praxistest. Bad Heilbrunn: Verlag Julius Klinkhardt. ISBN 978-3-7815-2448-4. 234 Seiten.
Authors: Mendl Hans
Published: May 2022

-
The clinical pattern of intentional injuries at a primary Saudi Arabian trauma center
Authors: Shirah Bader Hamza , Shirah Hamza Asaad , Zabeery Ibrahim Abdulaziz , Sogair Osama Abdulqader , Alahmari Ahmed Medawi , Alhaidari Wael Awad , Alamri Maher Hamdan , Aljabri Waal Nafa
Published: May 2022

Purpose: The term “intentional injuries” refers to a spectrum of injuries resulting from self-inflicted injuries, interpersonal violence, and group acts of violence. Intentional injuries are underreported in Saudi Arabia. This study aimed to analyze and evaluate the characteristics of intentional injuries in patients who presented to the emergency department of a primary trauma center in Medina, Saudi Arabia in 2013.Methods: A prospective cohort database analysis of the clinical patterns and treatment outcomes of 252 patients who had intentional injuries between January and December 2013 was done.Results: The proportion of trauma patients with intentional injuries was 1.3%. The mean age was 34.2±9.4 years, 141 patients (56.0%) were males, and 111 (44.1%) were females (male to female ratio, 1.27:1). The majority (n=159, 63.1%) of injuries occurred at night. Most occurred outside the home (n=180, 71.0%). Financial problems (n=62, 24.6%) and social disputes (n=61, 24.2%) were the most common reasons. Sharp objects (n=93, 36.9%) were the most common weapons used. The head and neck were the most commonly injured areas (n=63, 54.4%). Superficial cuts (n=87, 34.5%), were the most common type of injury. Suturing of wounds (n=54, 21.4%) and surgical debridement (n=47, 18.7%) were the most commonly performed modalities of management.Conclusions: We conclude that intentional injuries in Saudi Arabia are a health care hazard that is, unfortunately, underreported. The clinical pattern is similar in most aspects to international reports but differs in certain features due to the specific religious and conservative characteristics of the community. Nationwide clinical studies are strongly recommended.
The incidence of unexpected delays in uploading outside radiologic images in the transfer of patients with major trauma
Authors: Woo Si Jun , Kim Yong Oh , Kim Hyung Il
Published: May 2022

Purpose: Critically ill patients are frequently transferred from one point of care to a hospital that can provide a higher level of care. To achieve optimal treatment within the targeted window of time necessary for time-sensitive cases like major trauma, rapid transportation and decision making are essential. Transferred patients have often undergone radiologic imaging at the referring hospital. Examining these outside images is paramount. Therefore, this study was conducted to estimate the upload time of outside images.Methods: This retrospective study was conducted from January to April 2020. Patients transferred from other hospitals with digitally recorded CDs or DVDs of radiologic or diagnostic images were included. When the patients were registered at the emergency department reception desk, the digital images were transmitted to our picture archiving and communication system using transmission software. The time of upload and the numbers of digital images were recorded. The time interval from patient registration to the time of upload was calculated.Results: The median number of images was 688 in the trauma team activation (TTA) group (688 in the TTA group, 281 in the non-TTA trauma group, and 176 in the nontrauma group, respectively; P<0.001). The median upload time was 10 minutes. The longest upload time was 169 minutes. The upload time was more than 20 minutes in 12 cases (19.4%).Conclusions: Patients with major trauma bring more images than patients with other diseases. Unexpected delays (>20 minutes) were noted in approximately 20% of cases. It is necessary to minimize this time.
Exploring the Mediating Effect of Emotional Intelligence on Perceived Stress and Interpersonal Relationships Among Nursing Students
Authors: Tung Chun-Ping , Rong Jiin-Ru
Published: May 2022

The aims of this study were twofold: 1. exploring the relationships of perceived stress (includes three types of emotions: stress, depression, and anxiety), emotional intelligence, and interpersonal relationships among nursing students, and 2. examining the mediating effect of emotional intelligence in perceived stress (stress, depression, and anxiety) on the interpersonal relationships of nursing students. The study was a cross-sectional design. There were 313nursing students participating in the study and they were recruited from a university in northern Taiwan. The data were self-administrated by participants and collected from four scales: the Emotional Intelligence Scale, the Social Relationship Scale, the Depression Anxiety Stress Scale, and the demographic instrument. The main findings of this study were as follows: (1) Stress perception was significantly positively correlated with depression and anxiety. Emotional intelligence was positively correlated with interpersonal relationships. All the perceived stress, anxiety, and depression significantly negatively correlated with emotional intelligence and interpersonal relationships. (2) The results concluded that the impact of perceived stress on interpersonal relationships was significantly mediated by emotional intelligence. In conclusion, this study confirmed that emotional intelligence is one of the most important mediators, which can mediate the negative impacts from perceived stress to interpersonal relationships. For nursing education, the result provides a new direction in improving the emotional intelligence and ability of nursing students to help students manage stress and build interpersonal and professional relationships.
Impact of the COVID-19 pandemic on the academic life of higher education students: A rural South African perspective from a global study
Authors: Alex J. K.
Published: May 2022

Globally, the COVID-19 pandemic has become a greatest challenge in all sectors of life in the 21st Century. Due to worldwide lockdown and social distancing regulations, higher education institutions who offer face-to face classes had to go online to provide educational services to their students, which had major impacts on student lives. To study the immediate effects of it, a global study on the life of higher education students, initiated by University of Ljubljana (with international partners) was conducted as a voluntary and anonymous online survey across the world started on 5 May 2020. The survey targeted higher education students ‒ on what student life looks like during the COVID-19 pandemic, in different parts of the world. This article reports on part of that global study, reporting on the teaching and learning aspect of a sample of 274 undergraduate students from a South African rural higher education institution (HEI) who participated in the study. Thus, this article highlights the immediate impacts of the pandemic during 5 May – 15 June 2020 of the rural HEI. The study is important as the student perspective can have an impact on post- COVID academic policies of HEIs with similar contexts.
Dominance of Three Sublineages of the SARS-CoV-2 Delta Variant in Mexico
Authors: Taboada Blanca , Zárate Selene , Muñoz-Medina José Esteban , Sanchez-Flores Alejandro , García-López Rodrigo , Herrera-Estrella Alfredo , Boukadida Celia , Gómez-Gil Bruno , Selem Mojica Nelly , Rosales-Rivera Mauricio , Salas-Lais Angel Gustavo , Gutiérrez-Ríos Rosa María , Loza Antonio , Rivera-Gutierrez Xaira , Vazquez-Perez Joel Armando , Matías-Florentino Margarita , Pérez-García Marissa , Ávila-Ríos Santiago , Hurtado Juan Manuel , Herrera-Nájera Carla , Núñez-Contreras José , Sarquiz-Martínez Brenda , García-Arias Víctor , Santiago-Mauricio María , Martínez-Miguel Bernardo , Enciso-Ibarra Julissa , Cháidez-Quiróz Cristóbal , Isa Pavel , Wong-Chew Rosa María , Jiménez-Corona María-Eugenia , López Susana , Arias Carlos F.
Published: May 2022

In this study, we analyzed sequences of SARS-CoV-2 isolates of the Delta variant in Mexico, which completely replaced other previously circulating variants in the country due to its transmission advantage. Among Delta sublineages detected, 81.5 % were classified as AY.20, AY.26, and AY.100. According to publicly available data, these sublineages only reached a world prevalence of less than 1%, suggesting a possible Mexican origin. The signature mutations of these sublineages are described, and phylogenetic analyses and haplotype networks were used to track their spread across the country. Other frequently detected sublineages include AY.3, AY.62, AY.103, and AY.113. Over time, the principal sublineages showed different geographical distributions, with AY.20 predominant in Central Mexico, AY.26 in the North, and AY.100 in the Northwest and South/Southeast. This work describes the circulation, from May to November 2021, of the primary sublineages of the Delta variants associated to the third wave of the COVID-19 pandemic in Mexico and reinforces the importance of SARS-CoV-2 genomic surveillance for timely identification of emerging variants that may impact public health.