bluuebunny/crossref_metadata_2025 huggingface dataset:
Customer Experience: Conceptualization, Measurement, and Application in Omnichannel Environments
Authors: Gahler Markus , Klein Jan F. , Paul Michael
Published: September 2022

Managing customer experiences has become a key strategic priority for service research and management. Yet researchers and managers lack a customer experience (CX) measure that applies to the different experience partners, touchpoints, and journey stages in the omnichannel environments of today’s service industries. Without such a common measure, empirical research on CX remains fragmented, and service companies continue to struggle to improve customer interactions in customer journeys. To address this shortcoming, this article proposes an omnichannel-capable measurement of CX that applies to different customer interactions in the omnichannel environment. With seven studies, the authors develop and validate a six-dimensional, 18-item CX scale. The proposed CX scale overcomes the fragmentation of existing scales in service research and provides a valid measure that can be used consistently for various customer interactions in omnichannel environments. This article details how the proposed CX scale can monitor and compare CX for different interactions in customer journeys (i.e., pain-point analysis), as well as improve CX features and their marketing outcomes (i.e., CX profiling). By overcoming the existing fragmentation in available scales and providing a common omnichannel CX measure, this CX scale establishes an empirical foundation for developing CX knowledge and advancing related service research.
Multimodal ocular imaging in Proteus syndrome
Authors: Salerni Annabella , Scartozzi Luca , Piccinni Fabrizio , Mosca Luigi , Mattei Roberta , Leoni Chiara , Onesimo Roberta , Zampino Giuseppe , Rizzo Stanislao
Published: September 2022

In this report we illustrate the ophthalmologic assessment of two patients affected by Proteus Syndrome (PS), an extremely rare genetic disorder. Case #1 describes a 26 year old male patient followed for multiple ophthalmic anomalies: a limbal dermoid cyst, a unilateral cataract, bilateral nystagmus, severe myopia and unilateral optic nerve head drusen. Case #2 describes a 20 year old female patient referred to our Ophthalmology Department for a routine ophthalmologic evaluation after being treated for 3 years with Miransertib (an experimental AKT-pathway inhibitor). Both patients underwent a complete ophthalmologic examination and a multimodal imaging evaluation. The multimodal imaging approach has revealed useful to evaluate both cases in detail and to keep track of disease evolution over time, moreover providing helpful features to further characterize this rare syndrome.
South Asian youth mental health in Peel Region, Canada: Service provider perspectives
Authors: Islam Farah , Qasim Syeda , Ali Muhanad , Hynie Michaela , Shakya Yogendra , McKenzie Kwame
Published: September 2022

The Peel Region of Toronto, Canada is home to over a third of the province's South Asian population. Youth are at a vulnerable time period in terms of their mental health. South Asian youth populations may face additional challenges to their mental health such as acculturative stress, intergenerational conflict, and racism and discrimination. This qualitative study set out to understand the mental health concerns and service access barriers experienced by South Asian youth populations in the Peel Region of Toronto, Canada from the perspective of mental health service providers. In-depth semi-structured interviews were carried out with mental health service providers (n  =  22) who work with South Asian youth living in Peel Region. Thematic analysis was used to elucidate themes related to mental health stressors and service access barriers experienced by youth. According to mental health service providers, South Asian youth navigate a number of unique stressors related to the domains of culture, religion, and family dynamics, experiences of discrimination, the impact of migration, beliefs around mental illness and help-seeking, help-seeking trajectories and therapy recommendations, and lastly, sex differences. Mental health service providers outlined steps needed to effectively address the unique mental health challenges, best practice guidelines, and recommendations for working with South Asian youth, families, and communities to provide a practical and nuanced overview on how a multi-level strategy for mental health care can effectively meet the needs of South Asian youth populations.
Adaptability of traditional villages as tourist destinations in Yellow River Basin, China
Authors: Wang Fang , Zhao Xingguang , Qiu Yanxian , Luo Jie
Published: September 2022

Tourism has become an indispensable aspect of rural development. For traditional villages with historical and cultural importance, whether the development of tourism had led to traditional villages being restricted or supported needs to be studied. Taking 684 traditional villages in the Yellow River Basin in China as an example, we used Adaptive Cycle Theory to construct an index system and explored the adaptability of Chinese traditional villages in terms of undergoing development for tourism by describing the spatiotemporal coupling and evolution process of village adaptation. Then, we constructed a binary logistic regression model to measure the adaptation differences for villages providing different tourism services. The results showed that from 2000 to 2018, the social adaptability of traditional villages tended to deteriorate and was spatially and regionally different. Compared with the traditional villages without tourism, in villages where tourism has been developed, the adaptability of villages dominated by agriculture is poor. Villages dominated by traditional national culture and ecological leisure agriculture showed higher adaptability. By exploring the adaptation model and evaluating the technological development of traditional villages, we provide support for enhancing the interaction between the external and internal resources of tourism-oriented traditional villages.
Frictional matterings: (Re)thinking identity and subjectivity in the coming-to-be of literacies
Authors: Kuby Candace R , Price Erin , Gutshall Rucker Tara
Published: September 2022

The authors take up the guest editors’ invitation to address the difference that posthumanist and feminist ‘new’ materialist theories make and why this matters politically and ethically. Alongside events from an early childhood (kindergarten) classroom, the authors engage with current conversations which build on and extend Kimberlé Crenshaw's theory of intersectionality with post-philosophies by scholars who identify as Black feminist, Women of Colour feminist, queer theorist, Chicana and/or Indigenous scholars. In an iterative, slow thinking-making-with-reading, this contemplation brings intersectionality and post-philosophies into conversation to explore diffractive-affirmative possibilities for social and curricular (re)shapings. The authors create a philosophical playground to think identity and subjectivity when engaging with these theories both with/in classroom events and with/in their own co-constituted scholarly and teacherly becomings. The authors set forth several potentially generative frictions in teaching and researching environments.
Acetoacetate Improves Memory in Alzheimer’s Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation
Authors: Wu Xiao-Jun , Shu Qin-Qin , Wang Bin , Dong Lan , Hao Bin
Published: September 2022

The ketone bodies, especially the β-hydroxybutyrate, had been shown to modulate the function of the central nervous system and prevent the pathological progression of Alzheimer’s disease (AD). However, little is known about the role of acetoacetate in the AD brain. Thus, we intraventricularly injected acetoacetate into familial AD mice (APPSWE) for 14 days and monitored their memory and biochemical changes. During the behavior test, acetoacetate at 100 mg/kg led to significant improvement in both Y-maze and novel object recognition tests (NORTs) (both P < .05), indicating ameliorating spatial and recognition memory, respectively. Biomedical tests revealed two mechanisms were involved. Firstly, acetoacetate inhibited the GPR43-pERK pathway, which led to apparent inhibition in tumor necrosis factor-α and Interleukin-6 expression in the hippocampus in a concentration-dependent manner. Secondarily, acetoacetate stimulated the expression of hippocampal brain-derived neurotrophic factor (BDNF). We concluded that acetoacetate could ameliorate AD symptoms and exhibited promising features as a therapeutic for AD.
Removal of Basic Fuchsine (BF) in aqueous solution by Adsorption Process onto ‘Prunus Cerasefera’ (LPC) - Kinetics, Isotherm modeling and Thermodynamic Study
Authors: Abbas Moussa
Published: September 2022

The Leaves Pruna Cerasefera (LPC) was developed for the adsorption of Basic Fuchsin (BF) from its aqueous solution. LPC with a specific surface area of 22 m2/g was characterized by the BET surface area, Fourier transform infrared spectroscopy (FTIR), and pH of zero point charge pHpzc (=6.80). The adsorptive properties of LPC with BF was conducted at variable stirring speed (100–1000 rpm), adsorbent dose (2–16 g/L), solution pH (2–10), initial BF concentrations (100–200 mg/L), contact time (0–60 min), and temperature (295–313 K) using batch mode operation to find the optimal conditions for a maximum adsorption. The adsorption mechanism of BF onto LPC was studied using the first pseudo order and second pseudo order kinetic models. The BF elimination was found to follow a pseudo-second order kinetic model with a determination coefficient ( R2) of 0.999. The experimental data were fitted to Langmuir, Freundlich, Temkin, and Elovich isotherms, and the equilibrium behavior explained by the Langmuir model provides the best correlation ( qmax = 158.73 mg/g, R2 = 0.999 at 25°C). The effect of adsorption at different temperatures have been studied for the determination of thermodynamic parameters, that is, the free energy (Δ G° = −5.4437 to −4.5879 kJ/mol), enthalpy (Δ H° = −19.469 kJ/mol), and entropy (Δ S° = −0.4554 kJ/mol K). The negative values of Δ G° and Δ H° values that the overall adsorption is spontaneous and exothermic in nature. Our work has a dual environmental aspect; on the one hand the valorization of a natural by-product namely LPC, and on the other hand, the elimination of BF from aqueous solutions. The present adsorbent may be considered as an alternative adsorbent for the better performance of the BF removal from its aqueous medium.
Removal of methylene blue pollutant from the textile industry by adsorption onto Zeolithe: Kinetic and thermodynamic study
Authors: Abbas Moussa
Published: September 2022

In the textile industry, various acidic, basic and reactive dyes are used for different applications; the aim of this study is to eliminate Methylene blue (MB) a dangerous dye by a zeolithe produced at low economic cost by adsorption in batch mode. The adsorbent was characterized by the FTIR spectroscopy, X-ray diffraction (XRD), and point of zero charge (pHpzc = 10.42). Some examined factors were found to have a significant impact on the adsorption capacity of the zeolithe like the initial dye concentration (5–25 mg/L), solution pH (2–14), adsorbent dose (0.1–2 g/L), agitation speed (150–500 rpm), particles size (100–500 µm) and temperature (298–333 K). The best capacity was found at pH 6 with an adsorbent dose 0.2 g/L, an agitation speed 200 rpm and a contact time of 40 min. Modeling the Kinetics and Isotherms data shows respectively that the pseudo-second-order kinetic model and Langmuir isotherm provide better fitness to the experimental data with the maximum adsorption capacity of 12.50 mg/g at 25°C. The adsorption isotherms at different temperatures have been used for the determination of the free energy (ΔG°); enthalpy (ΔH°) and entropy (ΔS°) to predict the nature of MB adsorption. The positive values of ΔG° and ΔH° indicate a non-spontaneous and endothermic MB adsorption with a physisorption process. The adsorbent elaborated from the zeolithe was found to efficient and suitable for the removal of reactive dyes from aqueous solutions, due to its, low cost preparation and good adsorption capacity. The photocatalysis of MB in the presence of hybrid semiconductor (TiO2/Zeolithe) constitutes the logical continuation of this study.
Outcome prediction value of critical area perfusion score for acute basilar artery occlusion
Authors: Sun Dapeng , Huo Xiaochuan , Raynald  , Mo Dapeng , Gao Feng , Ma Ning , Albers Gregory W , Miao Zhongrong
Published: September 2022

Purpose

To investigate the performance of the Critical Area Perfusion Score (CAPS), based on computed tomography perfusion (CTP) time to maximum (Tmax) > 10s maps, to predict the outcome in acute basilar artery occlusion (BAO) in patients undergoing endovascular treatment (EVT).

Methods

We perform a retrospective analysis of a prospectively collected database of acute BAO treated with EVT in a comprehensive stroke center. The favorable outcome was defined as the 90-day modified Rankin Scale (mRS) ≤ 3. We performed the logistic regression analysis to find the independent predictors of the favorable outcome. Then, we used receiver operating characteristic analyses to assess the predictive value of the imaging parameters, including CAPS, Posterior Circulation Alberta Stroke Program Early CT Score (PC-ASPECTS), pons midbrain index (PMI), posterior circulation computed tomography angiography (PC-CTA) score, Basilar Artery on Computed Tomography Angiography (BATMAN) score, and CTP parameters. Finally, the Delong test was used to compare the area under the curve (AUC) of CAPS against the other imaging parameters.

Results

Of the 65 enrolled patients, the incidence of the favorable outcome was 44.6% (29/65). Low CAPS (per 1- point increased odds ratio [OR], 0.43; 95% confidence interval [CI], 0.22–0.86; P = 0.017) and admission National Institutes of Health Stroke Scale (NIHSS) (per 1- point increased OR, 0.80; 95% CI, 0.70–0.91; P = 0.001) were independently associated with favorable outcome. The AUC of CAPS was 0.83 (95% CI, 0.74–0.93; P < 0.001) with ≤ 3 cut-off value, 89.66% sensitivity, 77.22% specificity, and 80.00% accuracy, which was greater than the other imaging parameters (All P for Delong test < 0.05).

Conclusions

CAPS was the most accurate imaging-based outcome predictor in acute BAO patients. Future large prospective multicenter studies are needed to verify these results.
Elderly Patients’ Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol
Authors: Channa Kiran K. , Venables Rebecca , White Simon
Published: September 2022

The ageing population has resulted in an increase in multimorbidity and polypharmacy, and subsequently the complexity of optimising elderly patients’ medicines. The need for deprescribing can arise from factors such as increased susceptibility to adverse effects of medicines in older age, due to functional and cognitive changes, which increases elderly people’s risk of harm. Previous questionnaire-survey-based research suggests that patients tend not to disagree with deprescribing, but qualitative research on patients’ perspectives on deprescribing appears sparse and focused on specific conditions, circumstances (e.g., terminal illness) or medicines. Further exploration of this area is therefore important for health professionals, and greater understanding in particular is needed about elderly patients’ perspectives on the acceptability of deprescribing and how best to conduct deprescribing consultations. This study aims to explore these issues, with an approach informed by the Theoretical Framework of Acceptability (TFA). Semi-structured, audio-recorded interviews will therefore be undertaken with a purposive sample of approximately 20 hospital in-patients who are ≥65years of age, prescribed at least one regular medicine and have multimorbidities and/or frailty. Two acute Trusts were identified through existing networks where patients will be identified by the ward pharmacist and recruited to the study by the researcher. Due to the nature of the discussion and the potential vulnerable nature of participants, a distress protocol has been created to support management of any distress or fatigue that may occur. The TFA has been used so far to develop the study objectives and interview guide topics. The interview guide has been structured into five broad topics, which will cover the constructs of the TFA. Interview recordings will be transcribed verbatim and analysed using the Framework Analysis technique, informed by the TFA.
‘It's like we’re in two different schools’: Contrasting stories of teacher and leader autonomy within a distributed approach to leadership
Authors: Keddie Amanda , Blackmore Jill , MacDonald Katrina
Published: September 2022

The articulation of school autonomy into practice nationally, regionally and locally is highly situated in terms of what it enables or impedes with regard to the professional autonomy of principals and teachers. Principal autonomy does not necessarily mean greater teacher professional autonomy. In this paper, we draw on a three-year qualitative study investigating the social justice implications of school autonomy reform in Australia. We present interview data from a case study of a large secondary college to present two conflicting stories of autonomy. Supported by a managerial restructure reflecting distributed leadership, we juxtapose the positive account of autonomy expressed by the leadership team with the negative one expressed by teachers. We explore the justice implications of this disjuncture and argue the importance of critically examining the complex ways in which the intentions and enactments of distributed leadership can be differently articulated and understood within the context of school autonomy reform.
Object coding in peripersonal space depends on object ownership
Authors: Lenglart Lucie , Cartaud Alice , Quesque François , Sampaio Adriana , Coello Yann
Published: September 2022

Previous studies have shown that objects located in the peripersonal space (PPS) receive enhanced attention, as compared with extrapersonal space (EPS), However, most objects in the environment belong to someone in particular and how object ownership influences object coding in relation to PPS representation is still unclear. In the present study, after having chosen their own mug, participants performed a reachability judgement task of self-owned and other-owned mugs presented at different distances while facing a virtual character. This task was followed, on each trial, by a localisation task in which participants had to indicate where the mug, removed from view, was previously located. The two tasks were separated by a 900-ms visual mask during which the virtual character was unnoticeably shifted by 3° to evaluate the spatial frame-of-reference used. The results showed that self-owned mugs were processed faster than other-owned mugs, but only when located in the PPS. Furthermore, reachability judgements were biased for self-owned mugs, leading to an extension of the PPS representation, especially for participants with a high score on the fantasy scale of Interpersonal Reactivity Index (IRI). Finally, the virtual character shift altered the localisation performance but only for the distant mugs, suggesting a progressive shift from egocentric to allocentric frame-of-reference when moving from the PPS to EPS, irrespective of object ownership. Overall, our data reveal that the representations of ownership and PPS interact to facilitate the processing of manipulable objects, to an extent that depends on individual sensitivity to the social presence of others.
Arabic digit processing in adults with mathematical learning disability
Authors: Lepoittevin Samuel , Keymolen Gaétane , Andres Michael , Visscher Alice De
Published: September 2022

The processing of Arabic digits is a core difficulty of children suffering from mathematical learning disability (MLD). Dominant accounts assume a semantic impairment affecting either the magnitude representation per se or its access from numerical symbols. But recent data have raised the hypothesis that the impaired processing of Arabic digits may be explained by a selective deficit of digit visual recognition (i.e., recognising a symbol as one of the digits, no matter its identity or numerical meaning). This study aims at testing whether the difficulty to process Arabic digits remains prevalent in adults with MLD and whether it is effectively associated with a digit visual recognition deficit. To do so, we compared 19 adults with MLD to 19 matched controls in an Arabic digit comparison task that required to identify the largest of two digits, and in an Arabic digit lexical decision task that required to decide whether a visual stimulus is a digit or not. The results showed that MLD participants took more time than control participants to perform the comparison task. In contrast, their performance in the digit lexical decision task was within the range of the control participants. Overall, this finding indicates that adults with MLD continue to experience difficulties to process the magnitude of Arabic digits efficiently, and this cannot be explained by a visual recognition deficit for Arabic digits. We conclude that their difficulties are best explained by an impaired representation of number magnitude or by an impaired access to this representation.
The virtual mother: Mumsnet and the emergence of new forms of ‘good mothering’ online
Authors: Bailey Lucy
Published: September 2022

Whilst previous research into mothering on social media has focused on representations of intensive mothering ideology, this paper argues that social media are fundamentally changing mothering discourses for some users. The paper explores ‘good’ mothering in digital communities by considering: the legitimised expression of ambivalent emotions in digital mothering communities; the shifting relationship between private and public, with implications for new forms of maternal intimacy; the forms of surveillance engaged in, and resisted, online; and the opportunities for women to play with alternative identities. Through analysis of posts on the British mothering internet forum ‘Mumsnet’, the paper suggests the concept of virtual mothering to encapsulate the emerging ways in which mothering is performed through online spaces. Four aspects of virtual mothering discourse are explored – perfection, privacy, politics and play.
Emotions as Affective Position-Takings and as Nonconceptual Meta-Representations: A Comparison
Authors: Reisenzein Rainer
Published: September 2022

The theory of emotions as affective position-takings (PT) is investigated from the perspective of a computational model of the belief-desire theory of emotions (CBDTE) proposed by the author. Both theories assume that a core subset of typical emotion episodes are the products of an evaluation process in which cognized states of affairs are evaluated for their congruence with the person's desires; and that emotions are, on the conscious level, feelings of pleasure and displeasure. However, according to PT the evaluation is a concern-based construal and emotional feelings are intrinsically object-directed, whereas according to CBDTE, the evaluation is performed by a hardwired mechanism that produces nonintentional feelings. Furthermore, CBDTE suggests that hedonic feelings are simultaneously reactions to the detection of value, and representations of the detected value.
Finish-line photography system based on multi-scale convolutional neural network deblurring
Authors: Jin Zhixin , Tian Wenbo
Published: September 2022

In sports science research, the dynamic non-uniform blur caused by the movement of running athletes is a challenging problem in computer vision, that seriously affects the judgment accuracy of the finish-line photography system. With the rapid development of deep learning technology, image preprocessing, object identification, and object classification have been widely used and studied. This work proposes multi-scale convolutional neural network image deblurring to eliminate dynamic blur generated by the athletes in the shooting process. This network comprises three end-to-end convolutional neural subnetworks of different scales to recover the blurry athlete image caused by various factors on the field. The system effectively extracts the detailed edge of the image on each scale from coarse to fine. Many experiments show that this method can deblur the image captured by the finish-line photography system in real-time and rapidly achieve a better visual effect in the athlete’s dynamic image.
Variability in quantifying the Hill-Sachs lesion: A scoping review
Authors: Khan Shahrukh , Shanmugaraj Ajaykumar , Faisal Haseeb , Prada Carlos , Munir Sohaib , Leroux Timothy , Khan Moin
Published: September 2022

Background

Currently, is there no consensus on a widely accepted measurement technique for calculating the Hill-Sachs lesion (HSL). The purpose of this review is to provide an overview of the techniques and imaging modalities to assess the HSL pre-operatively.

Methods

Four online databases (PubMed, Embase, MEDLINE, and COCHRANE) were searched for literature on the various modalities and measurement techniques used for quantifying HSLs, from data inception to 20 November 2021. The Methodological Index for Non-Randomized Studies tool was used to assess study quality.

Results

Forty-five studies encompassing 3413 patients were included in this review. MRA and MRI showed the highest sensitivity, specificity, and accuracy values. Intrarater and interrater agreement was shown to be the highest amongst MRA. The most common reference tests for measuring the HSL were arthroscopy, radiography, arthro-CT, and surgical techniques.

Conclusion

MRA and MRI are reliable imaging modalities with good test diagnostic properties for assessment of HSLs. There is a wide variety of measurement techniques and imaging modalities for HSL assessment, however a lack of comparative studies exists. Thus, it is not possible to comment on the superiority of one technique over another. Future studies comparing imaging modalities and measurement techniques are needed that incorporate a cost-benefit analysis.
Shades of Red: Changing Understandings of Political Loyalty in the Chinese Communist Party, 1921–2021
Authors: Doyon Jérôme , Yang Long
Published: September 2022

While changes in Chinese Communist Party (CCP) recruitment are generally described as different phases focused on recruiting either “reds” or “experts,” giving more or less weight to political or technical criteria, we instead stress the importance of changing understandings of political loyalty to examine these evolutions. By tracing these changes throughout the party's 100 years, we show that how the party understands loyalty is largely strategic, detached from a purely ideological approach. The CCP has alternatively approached loyalty in ascriptive terms, based on class background, and behavioural ones, looking at active displays of loyalty or passive obedience. The level and form of activism expected from party members and cadres have also dramatically changed over time. Relying on recruitment data, this article shows that it is paradoxically during periods of party expansion that the CCP becomes more politically demanding with its members.
Undesignated Glucagon in Illinois: An Issue of Access and Equity
Authors: Yonkaitis Catherine F. , Jacobs Jennifer
Published: September 2022

School nurses must identify and advocate for change when student safety is at risk. Using a population-focused approach (one that addresses the needs of a whole group rather than an individual), one Illinois nurse successfully sought legislation to address the need for undesignated glucagon in all Illinois schools. This article will tell her story and describe the steps all school nurses can take to make a population-level change through legislative advocacy.
Zinner’s syndrome: Triad of seminal vesicle cyst, ejaculatory duct obstruction and ipsilateral renal agenesis: A rare case series
Authors: Deka Hiranya , Thomas Appu
Published: September 2022

Zinner’s syndrome is a very rare congenital condition characterised by seminal vesicle cyst, obstruction of the ejaculatory duct and ipsilateral renal agenesis. Here, we present a 25-year- old young short-statured male presented with left lower abdominal colicky pain. MRI abdomen showed the absence of the left kidney with a seminal vesicle cyst on the left side. The cyst in question was laparoscopically de-roofed. A second case is a 16-years-old young male who presented with intermittent lower abdominal pain. MRI abdomen showed seminal vesicle cyst with ipsilateral absent kidney which is managed conservatively with medication.

Level of evidence: Not applicable
Robert Alter’s Translation of the Hebrew Bible: A Response to Lénart de Regt
Authors: Tioyé Samy Ikoa
Published: September 2022

This paper responds to Lénart de Regt's discussion (in this issue of TBT) of Robert Alter's translation of the Hebrew Bible. First is a summary of de Regt's discussion of Alter's translation. The second part presents the driving points of Alter's norms for reading the Bible as literature. The third part discusses the application of Alter's norms to translation and ends with a few examples and observations.
Translating Sexual Taboos
Authors: Palu Ma’afu
Published: September 2022

This paper outlines an approach for translating sexual references in the Bible in a culture that considers the subject taboo in public discussions. Such is the case in most Pacific Island cultures, especially in the Tongan culture. We will look at various examples of sex-related language, and conceptual metaphors in particular. For this, a method is proposed for understanding metaphorical expressions based on Lakoff and Johnson's cognitive linguistic view of metaphor. Then, this method is applied to biblical references to sex in the biblical storyline, focusing especially on the Old Testament. Finally, suggestions are offered for how best to translate sexual terms in Tongan Bible translation.
Characteristics of Sciatic Scoliotic List in Lumbar Disc Herniation
Authors: Zhao Yao , Qi Longtao , Ding Chenyuan , Quan Shuo , Xu Beiyu , Yu Zhengrong , Li Chunde
Published: September 2022

Study Design

Retrospective radiological study.

Objectives

Physical examination reveals sciatic scoliotic list (SSL) in some patients with lumbar disc herniation (LDH). We aimed to evaluate the coronal and sagittal parameters of the SSL curve, describe their characteristics, and establish a new classification system.

Methods

We retrospectively reviewed 230 patients (SSL group = 96; non-SSL group = 134) diagnosed with single-segment LDH from January 2018 to December 2020. The control group comprised 70 healthy volunteers. Radiographic parameters were compared between the groups.

Results

In the SSL group, the Cobb’s angle was 12.5 ± 5.3° (4.2-31.2), trunk shift 26.2 ± 17.9 mm (.0-88.2 mm), and apical vertebral translation 31.7 ± 16.0 mm (1.18-8.58 mm). Further, 62.5% of patients had L4/5 disc herniation, 76.0% had disc herniation at the convex side of the lumbosacral scoliosis, and 81.3% had disc herniation at the opposite side of the trunk shift. Compared to the control group, lumbar lordosis and thoracic kyphosis decreased, pelvic tilt increased, and the sagittal vertical axis moved forward in the other patients. The sagittal imbalance in the SSL group exacerbated. Using the positional relationship between vertebrae and the central sacral vertical line (CSVL), we identified two main SSL patterns with which 95.8% of the patients were defined as Type 1.

Conclusions

The SSL curve is characterized by a long thoracic or thoracolumbar curve, with a relatively straight sagittal profile and little rotation. Further, the lumbar and thoracic vertebrae shifts are on the same side as the CSVL. These features of the SSL curve differentiate it from other types of structural scoliosis.
A Theory of Marketing’s Contribution to Customers’ Perceived Value
Authors: Misra Shekhar , Pedada Kiran , Sinha Ashish
Published: September 2022

The way customers perceive value is fundamental to business survival and success and is central to marketing theory and practice. Perceived value as an overarching concept describes the contribution of marketing as a key driver in a firm’s success. Though perceived value has gained the attention of academics and practitioners in recent years, the conceptual roots have diverged in different directions. This article synthesizes the concept of customers’ perceive value and presents a theory of marketing’s role in it. This study develops a new theoretical framework of how marketing drives perceived value of customers by reducing and eliminating marketplace imperfections that are always present in oligopolistic markets.

This study develops a new theoretical framework of how marketing drives perceived value of customers. We first consider the constituents of customer value—the types of costs and benefits that determine customer’s utility from a purchase, and how marketing can influence these costs and benefits. We then draw upon economics and marketing theories to argue that irrespective of the conceptual lens one adopts, marketing’s primary function is to contribute to perceived value for firms’ customers, which in turn allows marketing to capture value.

This article presents four distinct propositions, which articulate how marketing creates value for customers by reducing different types of marketplace imperfections.

This article contributes to theory buildings in marketing literature. Laying out theoretical arguments to establish the existence of a marketing-value relationship is critical to validate the relevance and importance of marketing within the firm. The propositions presented in this article can be further used to investigate marketing challenges and questions.

From a managerial perspective, it is critical to understand the role of the marketing function in influencing customer value as well. Improved empirical understanding of marketing’s role will enable CEOs to better leverage their firms’ marketing to achieve strategic priorities. Furthermore, by identifying specific marketing activities that create value for customer in different circumstances, managers can more effectively build and leverage their marketing and allocate resources more judiciously.

This article synthesizes key developments in the area of customers’ perceived value and presents four novel propositions on marketing’s role in creating customer value.
Creating and Managing Value in Indian Management Education
Authors: Salunkhe Uday , Rajan Bharath , Natarajan Sujatha
Published: September 2022

Stakeholder theory and stakeholder engagement (SE) concepts have been widely used in management and marketing literature. In this study, we extend the SE concept to investigate value creation and management in Indian management education. Specifically, for an Indian management institute, we (a) define value, (b) identify nine value categories in which value can be created and managed, (c) advance a SE approach in creating and managing value, (d) identify and categorize value measures as contiguous and future measures, and (e) recognize the resources and capabilities needed to create and manage value. This is the first study in the Indian context to focus on value creation and management through the SE perspective. We conclude the study by discussing the implications of the proposed value categorizations for an Indian management institute and identifying areas for future research.
CyberKnife Stereotactic Body Radiotherapy as a treatment option for renal cell carcinoma: The complex case of a patient with unilateral renal agenesis
Authors: Soto-Monge Tatiana , Mejías Ricardo , Bermudez-Guzman Luis
Published: September 2022

Surgery is the standard treatment for local renal cell carcinoma (RCC), but many patients are medically inoperable and local approaches such as radiofrequency ablation and cryoablation may be limited to smaller tumours. Conventional radiotherapy has not been effective in RCC, but higher dose-per-fraction radiotherapy has shown high local control rates accompanied by low toxicity. This is particularly important in the case of patients with a solitary kidney, either congenital or due to previous surgical history. Here, we present the case of a 68-year-old female patient with congenital right renal agenesis diagnosed with clear cell renal cell carcinoma in her left (solitary) kidney. Originally, the patient started treatment with sunitinib but 9 months later, due to important side effects, it was decided to treat her with CyberKnife Stereotactic Body Radiotherapy (SBRT) using a prescription dose of 45 Gy in five sessions. Ten months after her treatment, PET/CT images showed no signs of local hypermetabolism and more than a year after treatment, kidney function remains stable. Curiously, PET/CT also revealed the presence of percutaneous tumour seeding probably after renal biopsy. This case supports the growing body of evidence showing the value of Stereotactic Body Radiotherapy for renal cancer, especially for medically inoperable renal tumours in a solitary kidney.
Visual impact assessment of urban developments around heritage landmarks using ULVIA method: (The case of Ark-e-Alishah monument in Tabriz)
Authors: Salimi Sirwan , Mirgholami Morteza , Shakibamanesh Amir
Published: September 2022

Urban intensification and erection of high-rise buildings can affect the visibility of urban landmarks and pedestrians’ viewshed toward important monuments. Current 2D and 3D Isovist techniques use static rather than dynamic and cumulative view sheds to analyze visibility. The purpose of this research is to develop a method called ULVIA 1 to assess the average visibility degree of urban landmarks in urban design process. Several factors such as observer and environmental characteristics as well as the concept of cumulative viewshed (using Nurbs data and ray casting in Grasshopper) have been considered to develop this method. Ark-e-Alishah Mosque in Tabriz was selected as a case study and three alternative 3D urban models were reproduced based on data and aerial photos of the monument and its urban context in 2003, 2020 and a proposed model. The ULVIA is executed in sequential steps. The findings reveal that the 2003 urban fabric creates visibility with normal intensity and distribution in all paths, the 2020 option does not have this balance, and the difference between riding and pedestrian mode is higher. The final proposed alternative has a higher visibility intensity and better distribution in both pedestrian and rider modes than other alternatives and therefore UlVIA has the potential to be integrated into urban design process to assess various development alternatives to achieve the best results in terms of historical landmarks’ visibility from surrounding environments.
OYO: Growth, Descend, Resilience, Resurgence
Authors: Kumar Raj , Singh Jagandeep
Published: September 2022

The year 2021 had drawn to a close. OYO, the India-based hotel start-up that had witnessed a pandemic-induced descent in business, appeared to have ticked the right boxes and was on a resurgence path. Founded in 2013, OYO grew rapidly in its initial years and had operations in 800 cities in 80 countries in 2019, just prior to the onset of COVID-19. It was the ‘fastest growing’ hotel chain in the world. Burgeoning losses at the time compelled OYO to make a strategic shift from aggressive growth to an accretive growth strategy. In the mid of its course correction endeavour, OYO’s business plunged in wake of COVID-19. OYO exhibited resilience and strived for resurgence even though it remained in the red. What were the resource-based and position-based sources of competitive advantage that propelled OYO’s meteoric rise initially and enabled it to remain resolute in the COVID-19 crisis? Can OYO be termed as successful in light of the Balanced Scorecard framework? What strategic options are available to OYO to maintain its growth trajectory in the post-pandemic phase?
Introduction to a review series on single-cell genomics: getting ready for clinical impact in leukemia and myeloid neoplasms
Authors: Sturgess Katherine H. M. , Wilson Nicola K. , Göttgens Berthold
Published: September 2022

Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myeloproliferative neoplasm, leading experts bring us up to date with recent data and speculate how these rapidly developing technologies may inform the directions of clinical care.
Eltrombopag in patients with chronic immune thrombocytopenia in Asia-Pacific, the Middle East, and Turkey: final analysis of CITE
Authors: Wong Raymond Siu Ming , Yavaşoğlu İrfan , Yassin Mohamed A. , Tarkun Pınar , Yoon Sung-Soo , Wei Xie , Elghandour Ashraf , Angchaisuksiri Pantep , Ozcan Mehmet , Yang Renchi , Mattar Mervat , Rahman Masiur , Ingles Sara , Goldbrunner Michael , Frueh Jennifer A. , Jang Jun Ho
Published: September 2022

CITE was a prospective, noninterventional study in adult patients with chronic immune thrombocytopenia treated with eltrombopag under routine clinical care in Asia-Pacific, the Middle East, and Turkey. Data to assess eltrombopag usage, compliance, and outcomes were collected from May 2017 to December 2020. Platelet response was defined as platelet count ≥50 × 103/μL in the absence of rescue medications and splenectomy. Quality of life was evaluated using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire. Noncompliance was defined as the number of missed doses and number of days where the patient did not follow food instructions. A total of 231 patients were enrolled; the median (range) duration of eltrombopag treatment was 484.5 (1-642) days. Compliance to prescribed eltrombopag dose since the previous routine visit was high at ≥96.0%. Baseline median platelet count was 19.0 × 103/μL, which increased to ≥50 × 103/μL at month 2 and mostly fluctuated between 70 × 103/μL and 100 × 103/μL thereafter. The median time to first platelet response was 1.05 (95% confidence interval: 0.92-1.28) months, and the median (interquartile range) maximum duration of platelet response was 193 (57-456) days. FACIT-F scores improved from a mean (standard deviation) 34.4 (12.1) at baseline to 38.5 (9.1) at month 18. Adverse events occurred in 50.9% of patients (n = 116), the most common being upper respiratory tract infection (8.3%) and headache (6.6%). These findings confirmed the effectiveness of eltrombopag treatment in routine practice and reassured that real-world compliance to eltrombopag-prescribed doses and dietary instructions in Asia-Pacific, the Middle East, and Turkey were in line with current recommendations.
Variants influencing age at diagnosis of HNF1A-MODY
Authors: Ludwig-Słomczyńska Agnieszka H. , Seweryn Michał T. , Radkowski Piotr , Kapusta Przemysław , Machlowska Julita , Pruhova Stepanka , Gasperikova Daniela , Bellanne-Chantelot Christine , Hattersley Andrew , Kandasamy Balamurugan , Letourneau-Freiberg Lisa , Philipson Louis , Doria Alessandro , Wołkow Paweł P. , Małecki Maciej T. , Klupa Tomasz
Published: September 2022

Background

HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease onset, but other factors are postulated to influence this trait. Here, we searched for genetic variants influencing age of HNF1A-MODY onset.

Methods

Blood samples from 843 HNF1A-MODY patients from Czech Republic, France, Poland, Slovakia, the UK and the US were collected. A validation set consisted of 121 patients from the US. We conducted a genome-wide association study in 843 HNF1A-MODY patients. Samples were genotyped using Illumina Human Core arrays. The core analysis was performed using the GENESIS package in R statistical software. Kinship coefficients were estimated with the KING and PC-Relate algorithms. In the linear mixed model, we accounted for year of birth, sex, and location of the HNF1A causative variant.

Results

A suggestive association with age of disease onset was observed for rs2305198 (p = 2.09E−07) and rs7079157 (p = 3.96E−06) in the HK1 gene, rs2637248 in the LRMDA gene (p = 2.44E−05), and intergenic variant rs2825115 (p = 2.04E−05). Variant rs2637248 reached nominal significance (p = 0.019), while rs7079157 (p = 0.058) and rs2825115 (p = 0.068) showed suggestive association with age at diabetes onset in the validation set.

Conclusions

rs2637248 in the LRMDA gene is associated with age at diabetes onset in HNF1A-MODY patients.
Timing matters: there are significant differences in short-term outcomes between two time points of status epilepticus
Authors: Pan Yiwen , Feng Yu , Peng Weifeng , Cai Yang , Ding Jing , Wang Xin
Published: September 2022

Background

In 2015, the International League Against Epilepsy proposed a new conceptual definition of status epilepticus (SE) with two operational dimensions (t1 and t2) to guide emergency treatment. The purpose of this study was to compare clinical characteristics and prognoses of patients at these two different time points.

Methods

We conducted a prospective observational cohort study of consecutive adults diagnosed with SE. In case of convulsive SE, t1 is 5 min and t2 is 30 min, whereas in case of focal SE with impaired consciousness, t1 is 10 min, t2 is 60 min. Data on clinical characteristics, including age, gender, history of prior seizures, neuroimaging, semiology, duration, and etiology of SE, were collected. The primary outcome was mortality, with seizure recurrence as a secondary measure, and functional status as tertiary outcome of enrolled patients at 3 months after SE onset.

Results

We screened one hundred patients with SE, with a median age of 66 years and 61% were male. Fifty-six (56.0%) patients reached t1 of SE, while 44 (44.0%) reached t2 of SE. Convulsive SE (52.0%, n = 52) was more common than focal SE with impaired consciousness (48.0%, n = 48). Status epilepticus secondary to an acute symptomatic process was the most common (50%, n = 50). Patients meeting t2 of SE demonstrated a remarkably increased risk of mortality (unadjusted analysis-RR 3.606, 95%CI 1.552–8.376, p = 0.003; adjusted analysis-RR 2.924, 95%CI 1.221–7.003, p = 0.016) and unfavorable functional status (unadjusted analysis-RR 1.803, 95%CI 1.280–2.539, p = 0.001; adjusted analysis-RR 1.664, 95%CI 1.184–2.340, p = 0.003) at 3 months compared to those who only reached t1 of SE. Patients reaching t2 of SE were more likely to experience seizure recurrence, however, there was no significant difference between the two cohorts.

Conclusions

Our study provides strong support for the new definition of SE. Patients meeting t2 of SE tend to have a remarkably increased risk of mortality and unfavorable functional outcomes compared to those who only reached t1 of SE. Furthermore, patients were likely to experience seizure recurrence after undergoing an episode of SE. Physicians must be educated about prompt recognition and appropriate management of SE.