bluuebunny/crossref_metadata_2025 huggingface dataset:
Event horizon detection: Zenith view as seen by falling into a Schwarzschild black hole
Authors: Iida Yukiyoshi
Published: January 2023

To visualize what is seen by an observer in curved spacetime, both general relativistic effects and special relativistic effects need to be considered. In this study, the author analytically proved that the zenith view seen by an observer falling freely into a Schwarzschild black hole (that is, the observer’s view of the point on the opposite side of the black hole) becomes enlarged, ``redder,'' and darker as the observer falls from an arbitrary initial rest position. An equation expressing the magnification factor of the zenith view (as seen by a falling observer) was also derived. The derived factor characterizes the brightness and frequency of light observed to emanate from the zenith view. Using these results, the author derived visualizations of the zenith views for various scenarios. As expressed by the derivations presented here, the moment when the observer sees the zenith view appear twice as large compared to the initial rest position coincides with the crossing of the event horizon---the threshold beyond which no return is possible; that is, a freely falling observer can detect the horizon through the simple procedure of continuing to observe the zenith view. This result implies that the effect of aberration (as described by special relativity) dominates the effect of light deflection (as described by general relativity) while the observer is falling.
Nomogram for predicting postoperative overall survival of elderly patients with soft tissue sarcoma
Authors: Huang Zhangheng , Zhao Zhen , Zhou Zhigang , Kong Qingquan
Published: January 2023

Background: With the aging world population, the incidence of soft tissue sarcoma (STS) in the elderly gradually increases and the prognosis is poor. The primary goal of this research was to analyze the relevant risk factors affecting the postoperative overall survival in elderly STS patients and to provide some guidance and assistance in clinical treatment.
Methods: The study included 2,353 elderly STS patients from the Surveillance, Epidemiology, and End Results database. To find independent predictive variables, we employed the Cox proportional risk regression, model. R software was used to develop and validate the nomogram model to predict postoperative overall survival. The performance and practical value of the nomogram were evaluated using calibration curves, the area under the curve, and decision curve analysis.
Results: Age, tumor primary site, disease stage, tumor size, tumor grade, N stage, and marital status, are the risk variables of postoperative overall survival, and the prognostic model was constructed on this basis. In the two sets, both calibration curves and receiver operating characteristic curves showed that the nomogram had high predictive accuracy and discriminative power, while decision curve analysis demonstrated that the model had good clinical usefulness.
Conclusions: A predictive nomogram was designed and tested to evaluate postoperative overall survival in elderly STS patients. The nomogram allows clinical practitioners to more accurately evaluate the prognosis of individual patients, facilitates the progress of individualized treatment, and provides clinical guidance.
Clinical effects of hyperbaric oxygen therapy on paroxysmal sympathetic hyperactivity after cardiopulmonary resuscitation: a case series
Authors: Hongyu Wang , Yihao Li , Meng Zhao , Caihong Ren , Sisen Zhang
Published: January 2023

Background
After cardiopulmonary resuscitation (CPR), paroxysmal sympathetic hyperactivity (PSH) will appear due to extensive brain injury. PSH is a serious clinical syndrome, and it is often treated with drugs. However, the application of hyperbaric oxygen in the treatment(HBOT) of PSH is rarely reported in the literature.We aimed to investigate the clinical effects of single-chamber pure oxygen treatment on PSH following CPR.
Methods
We retrospectively analysed clinical data of four patients treated at our hospital who developed signs of PSH post-CPR and received HBOT at an early stage to assess the clinical effects of HBOT on PSH.
Results
Following 3–4 HBOT sessions, signs of PSH were substantially diminished, and patients’ Clinical Symptom Scale scores decreased significantly. The time to awakening was 34, 25, 38, and 28 days for cases 1–4, respectively.
Conclusions
HBOT alleviated PSH, reduced brain damage, and promoted a return to full consciousness. HBOT efficacy was significant in these patients, and promoting HBOT in the clinical setting is recommended.
A qualitative investigation of paediatric intensive care staff attitudes towards the diagnosis of lower respiratory tract infection in the molecular diagnostics era
Authors: Clark John Alexander , Morris Andrew Conway , Kanaris Constantinos , Inwald David , Butt Warwick , Osowicki Joshua , Schlapbach Luregn , Curran Martin D , White Deborah , Daubney Esther , Agrawal Shruti , Navapurkar Vilas , Török M. Estée , Baker Stephen , Pathan Nazima
Published: January 2023

Background
In the past decade, molecular diagnostic syndromic arrays incorporating a range of bacterial and viral pathogens have been described. It is unclear how paediatric intensive care unit (PICU) staff diagnose lower respiratory tract infection (LRTI) and integrate diagnostic array results into antimicrobial decision-making.
Methods
An online survey with eleven questions was distributed throughout paediatric intensive care societies in the UK, continental Europe, and Australasia. Participants were asked to rate the clinical factors and investigations they used when prescribing for LRTI. Semi-structured interviews were undertaken with staff who participated in a single-centre observational study of a 52-pathogen diagnostic array.
Results
Seventy-two survey responses were received; most were from senior doctors. Whilst diagnostic arrays were used less frequently than routine investigations (i.e. microbiological culture), they were of comparable perceived utility when making antimicrobial decisions. Prescribers reported that for arrays to be clinically impactful, they would need to deliver results within six hours for stable patients and within one hour for unstable patients to inform their immediate decision to prescribe antimicrobials. From 16 staff interviews, we identified that arrays were helpful for the diagnosis and screening of bacterial LRTI. Staff reported it could be challenging to interpret results in some cases due to the high sensitivity of the test. Therefore, results were considered within the context of the patient and discussed within the multidisciplinary team.
Conclusions
Diagnostic arrays were considered of comparable value to microbiological investigations by PICU prescribers. Our findings support the need for further clinical and economic evaluation of diagnostic arrays in a randomised control trial.
Trial registration
Clinicaltrials.gov, NCT04233268, https://clinicaltrials.gov/ct2/show/NCT04233268. Registered 18 January 2020.
Generators' inertia assessment by state estimation
Authors: Ramirez Juan M
Published: January 2023

This paper merges two well-known strategies to estimate the inertia of synchronous generators in operation: (i) the extended Kalman filter (EKF) state estimation is used to estimate state variables. On the other hand, (ii) a novel and accurate method is used to calculate the rate-of-change of frequency (RoCoF) from the estimated angular velocity or position. The primary assumption lies in the fact that it is assumed that it is possible to have the measurement of the frequency or angular velocity in the machine under study. Furthermore, calculations become more precise using the RoCoF than the derivatives calculated in the transient stability algorithm, mainly under the integration step utilised there. Thus, an accurate inertia estimation is achieved by combining these two tools. Results are presented for the 16-generator system.
Social Media Posts as a Window into Mental Health: A Machine Learning Approach
Authors: Ganie Aadil , Dadvandipour Samad
Published: January 2023

Mental health is a crucial factor influencing the overall well-being of humans, which has gained significant attention in recent times due to the high prevalence of mental health disorders and their detrimental effects on individuals and society. In an attempt to tackle this pressing issue, researchers have explored the possibility of using the copious amounts of data available on social media platforms to predict and classify mental health status. In our study, we analyzed three datasets: the first one comprising 7 classes (depression, anxiety, autism, mental health, schizophrenia, BPD, and bipolar), the second dataset comprising 2 classes (positive and negative), and the third dataset comprising 2 classes (suicide and non-suicide). The final dataset included 14 classes, with 7 belonging to the non-suicidal subset and 7 belonging to the suicidal subset. We employed logistic regression, support vector machines, and multinomial naive Bayes for classification and prediction, and evaluated the performance of our models using receiver operating characteristic (ROC) curves and confusion matrices. The logistic regression model outperformed the other models, achieving an accuracy of 80%. Our models have been deployed using streamlit, providing a user-friendly interface for predicting mental health status and risk for suicidal ideation. If the prediction of the social media post falls within the suicide subset class, a chatbot (GPT2) will be activated in an effort to engage the individual with suicidal ideation and reduce the likelihood of suicide. Our research serves as a helpful tool for mental health professionals and has the potential to be extended to other platforms, addressing the urgent need to detect and address mental health issues and suicidal ideation.
Metastatic Malignant Melanoma of the Stomach: An Unexpected Phenomenon of the Disease
Authors: Hosseini Akram , Rouhi Tina , Nematollahi Mahvash , Shiravani Javad Shokri
Published: January 2023

Background
Gastrointestinal (GI) melanomas are uncommon, and the stomach is a rare site for metastasis and accounts for 27% of the cases with GI tract metastatic melanoma. Clinical manifestations are usually nonspecific, and many patients are asymptomatic until the disease progresses further, but may be presented with nausea, vomiting, weight loss, abdominal pain, hematemesis, melena, and iron deficiency. The prognosis is very poor, and the median survival of the patient is 4 to 6 months. The diagnosis is confirmed with postoperative pathological examination and immunohistochemical study. Treatment options include surgical resection, immunotherapy, and targeted therapy.
Case Presentation:
The presented case is a 71-year-old male, previously diagnosed with cutaneous melanoma of the left retroauricular region, that presented with upper GI tract symptoms and cervical lymphadenopathies about one year after the diagnosis of the primary tumor. An upper GI endoscopy was done, and a pathological examination of the biopsy specimen confirmed the metastatic melanoma of the stomach.
Conclusion
Regarding the unfavorable outcome of gastric metastatic melanoma, the treatment choice is still under investigation. However, early diagnosis is important for the appropriate assessment of patients as candidates for surgical interventions.
The Role of Double Skin Facade Configurations on Optimizing Building Energy Performance in Erbil City
Authors: Naddaf Mohammed Siyamand , Baper Salahaddin Yasin
Published: January 2023

Carefully designing a building façade is the most crucial way to save energy. A double skin façade is one of the effective strategies for achieving energy efficiency. This depends on the configuration chosen for the double skin façade that synchronizes with climate conditions. The study aims to investigate the best-case scenario with appropriate double-skin façade configuration for optimizing building energy performance. A methodology for optimizing the building's initial condition was introduced using EnergyPlus and ClimateStudio according to the one-year period of Erbil city. Analyzation of double skin parameters performed through utilizing a multi-objective analysis approach. Four geometric configurations were assessed; building-high, story-high, shaft-box, and box-window. The results offered annual and seasonal consumption curves for each orientation. Shaft-box double skin façade significantly reduces the amount of cooling energy due to massive airflow between two skins. a significant drop in the annual cooling demand of 9–14%. The use of an appropriate double skin façade greatly benefits Erbil city climate as it can result in annual energy savings of up to 116,574 kWh.
Decreased Hospital-Acquired Respiratory Infections among elder Inpatients in General Hospital during the COVID-19 Pandemic
Authors: Li Qian , Zhao Lihua , Chen Jin , Qu Shuang , Niu Xiaoting , Zhu Ruixia , Hu Wei
Published: January 2023

Background
In order to avoid nosocomial transmission of COVID-19, various prevention and control measures have been strictly implemented in medical institutions. These strict measures can probably reduce the incidence of hospital acquired respiratory infections. We conducted this study to assess changes in the prevalence of hospital acquired respiratory infections during a period of national attention to the prevention the COVID-19 pandemic.
Methods
We retrospectively analyzed the clinical data of patients from October to December 2019 and from October to December 2020. The diagnostic of hospital acquired respiratory infections was based on CDC/NHSN criteria. We compared the incidence and mortality rate of hospital acquired respiratory infections between these 2 periods. We also used multivariate logistics regression analysis for risk factors associated with mortality.
Results
In 2020, a total of 2921 patients’ data were surveyed, as compared with 2211 patients in 2019. Incidence of hospital acquired respiratory infections was lower in 2020 (2.9% vs. 4.7%, P = 0.001). In hospital mortality of patients with hospital acquired respiratory infections had no significant difference (38.4% vs. 30.5%, p = 0.252). Multivariate logistics regression analysis showed that severe pneumonia (RR = 28.235, 95%CI: 10.122, 78.759, p = 0.000), previous malignant tumor (RR = 4.599, 95%CI: 1.768, 11.963, p = 0.002) and cardiac injury (RR = 2.264, 95%CI: 0.935, 5.485, p = 0.07) were associated with an increased risk of mortality.
Conclusions
The incidence of hospital acquired respiratory tract infections was significantly decreased during COVID-19 period as a result of the adoption of infection prevention and control measures in medical institutions. Elder patients with severe pneumonia and previous malignant tumor were at high risk for death in hospital.
A Pseudo-Inverse for Substitution Integral Operators
Authors: Moayyerizadeh Zahra
Published: January 2023

In this paper, we characterize substitution integral operators that have closed ranges on L2(µ). Next, we give an explicit formula for the pseudo inverse (Tφu )† of a substitution integral operator Tφu on L2(µ) space using conditional expectation operators.
Comparison of surgical parameters employing the NGenuity 3D Visual System vs. Conventional Surgical Microscope in Phacoemulsification surgery
Authors: -Giles Claudia Cáceres , Sánchez-Hoil Alejandro , Gonzalez-Salinas Roberto
Published: January 2023

Purpose To compare the surgical parameters used during cataract phacoemulsification surgery and the complication rate using two visualization systems, the NGENUITY® 3D Visualization System (3D) and the binocular microscope (BM).
Methods A total of 76 eyes of 76 consecutive patients underwent cataract and retinal surgery at the same surgical time, 34 (44.7%) in the BM group and 42 (55.3%) in the 3D group. Cataracts graded NII to NIII using LOCS II were included. At the end of the phacoemulsification surgery, the surgical parameters were recorded. In addition, the success rate for performing anterior continuous circular capsulorhexis, in-the-bag IOL placement, and the rate of complications were registered and compared.
Results A median age of 57 ± 16 years was found (range 28–84), and no significant difference was evident between both groups. Forty-nine patients (64.4%) were included in the BM group, and 27 (35.5%) were in the 3D group. The median CDE used in the BM group was 4.12 pcs (IQR 2.82-6.64); in the 3D group, it was 3.88 pcs (IQR 2.46-8.28) p = 0.751. In the quadrant extraction time, the median was 302.0 sec (IQR±146.5) in the MB group and 294.0 sec (IQR±500.0) in the 3D group with a p= 0.829. No complications were reported in either group.
Conclusion The NGENUITY® 3D Visualization System performs similarly to that achieved with the MB in phacoemulsification surgery in patients with retinal pathology.
Controlling Hybrid Transformers by Lyapunov Method for Application in Smart Distribution Network
Authors: Fereydouni Mahmoud , Rokrok Esmaeel , Taheri Shamsodin
Published: January 2023

The hybrid distribution transformer (HDT) is one of the essential pieces of equipment for future smart distribution networks. This paper proposes a control scheme based on the Lyapunov energy function (LEF) with output voltage feedback loops for the HDT series converter to overcome the limitations of the existing HDT control schemes, including steady-state error (SSE), and improve the transient response of the distribution network. Accordingly, an energy function is defined based on the energy of the series converter. The switching functions resulting from the control scheme based on the single-loop direct Lyapunov method (DLM) cause a significant SSE in the output voltage and distort the output voltage waveforms. The output voltage feedback loops of the LV network were added to the switching variables resulting from the LEF to fix SSE, achieve fast-tracking of the reference voltage, and compensate for the sag or swell of the of the grid. Simulation and experimental results on an HDT experiment prototype confirmed the proposed control method's steady state and dynamic performance. As a result of combining the output voltage feedback loops in the control variables, the proposed method has stable and dynamic performance in fast-tracking the reference voltage and robustness to parametric uncertainty in the proposed HDT series converter. Simple implementation and understanding are other advantages of the proposed control scheme.
Knowledge and Awareness of Sudanese Women toward Breast Cancer Detection
Authors: Hussein Abdulaziz A.A , Alamin Asma , Mohammed Magdoleen S.H , Adil Sara , Saeed Esraa , Ahussine Amna , Salih Alsadig , Alawd Alwaleed M.A , Adil Sondos
Published: January 2023

Background: The most frequent cancer in women is breast cancer (BC), which unfortunately have a high mortality in Sudan whereas the most of patients are diagnosed at late stages of this disease sequence either due to a lack of awareness or unviability of screening programs.
objective: to asses of the knowledge and awareness of breast cancer detection among Sudanese women 2022 - 2023.
Material and Methods: a community representative descriptive cross - sectional study of women aged 17 to 70 years in different Sudanese provinces were included using semi-structural interviewed questionnaire.
Results: out of 200 participants, mean age 39.8 (±12.13) years and the majority of them were aged between 41 and 50 years 54 (27%). 120 (60%) had no prior experience with breast cancer at all and 73 (36.5%) had never heard of breast self-examination for BC. The study resulted that the dominant of interviewed women 181 (90.5%) had a good awareness of breast cancer, 161 (80.5%) believed that breast screening must require for early detection of breast tumors. Breast changes, discharge and lump pain were the common prevalent reasons for breast screening in this study 95 (38.7%), 46 (18.7%) and 45 (18.3). It was clear that education level has a significant effect in the level of knowledge of breast cancer and its diagnostic screening tools among participants, with graduated women having adequate knowledge in comparison to whom not graduated women 92 (50.5%) and 89 (49.2%) (p value = 0.004 < 0.05). As well, the central resident participants had a good knowledge about breast cancer 112 (70 %) in compare with other residents.
Conclusion: awareness and knowledge of BC detection increase with increasing educational level and central urban living, there is an urgent need for an intensive breast cancer awareness programs and the availability of screening centers authorities in Sudanese periphery areas.
Optimization of Machine Learning Algorithms for Proteomic Analysis Using TOPSIS
Authors: Javanbakht T. , Chakravorty S.
Published: January 2023

The present study focuses on a new application of the TOPSIS method for the optimization of machine learning algorithms, supervised neural networks (SNN), the quick classifier (QC), and genetic algorithm (GA) for proteomic analysis. The main hypotheses are that the change in the weights of alternatives could affect the ranking of algorithms. The obtained data confirmed this hypothesis for their ranking. Moreover, adding labor as a cost criterion to the list of criteria did not affect this ranking. This was because candidate 3 had better fuzzy membership degrees than the two other candidates concerning their criteria. This work showed the importance of the value of the fuzzy membership degrees of the cost criterion of the algorithms in their ranks. The values of the fuzzy membership degrees of the algorithms used for proteomic analysis could determine their priority according to their score differences. One of the advantages of this study was that the studied methods could be compared according to their characteristics. Another advantage was that the obtained results could be related to the new ones after improving these methods. The results of this work could be applied in engineering, where the analysis of proteins would be performed with these methods.
Machine Learning Approach for Solar Irradiance Estimation on Tilted Surfaces in Comparison with Sky Models Prediction
Authors: Mbah O. M. , Madueke C. I. , Umunakwe R. , Okafor C. O.
Published: January 2023

In this study, two supervised machine learning models (Extreme Gradient Boosting and K-nearest Neighbour) and four isotropic sky models (Liu and Jordan, Badescu, Koronakis, and Tian) were employed to estimate global solar radiation on daily data measured for one year period at the National Center for Energy, Research and Development (NCERD) at the University of Nigeria, Nsukka. Two solarimeters were employed to measure solar radiation: one measured solar radiation on a tilted surface at a 15° angle of tilt, facing south, and the other measured global horizontal solar radiation. The measured global horizontal solar radiation and the time and day number were used as input for the prediction process. Python computational software was used for model prediction, and the performance of each model was assessed using statistical methods such as mean bias error (MBE), mean absolute error (MAE), and root mean square error (RMSE) (RMSE). Compared to the measured data, it was discovered that the Extreme Gradient Boosting (XGBoost) algorithm oﬀered the best performance with the least inaccuracy to sky models.
Changes in the pituitary — thyroid system during extracorporeal membrane oxygenation: a prospective observational study
Authors: Altshuler N. E. , Kutcyi M. B. , Gubarev K. K. , Bagzhanov G. I. , Popugaev Konstantin A.
Published: January 2023

INTRODUCTION: The severity of the patient's condition that required ECMO and the changes observed in the pituitary — thyroid system (decreased T4 and T3 levels, low-normal or decreased TSH level) can be considered as a lack of body reserves due to the developed critical illness. OBJECTIVES: Study changes of TSH, T3, T4 levels during the ECMO procedure, during weaning/death on the ECMO. MATERIALS AND METHODS: The prospective observational study was performed in intensive care unit (47 patients on ECMO). After connecting ECMO (D0), (D1-D3-D5-D7-D9), and until the completion of ECMO, assessment of TSH, FT4, FT3 levels was carried out. OBJECTIVE: Analysis of changes in thyroid hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) levels in blood plasma during ECMO, at ECMO weaning/death on ECMO. RESULTS: On the day of ECMO (D 0) and every second day, median FT4 levels were D0 (p = 0.03); D1 (p = 0.03); D3 (p = 0.05), D11 (p = 0.02) and last observation day (p = 0.009) between surviving and dying patients respectively. T3 level D5 (3.1–1.9; p = 0.002); D11 (3.7–2.5; p = 0.05), last day of follow-up (3.1–2; p = 0.001), respectively. On the last day of ECMO between the survived and non-survived patients there were the following: differences in TSH levels; negative correlation of lactate levels, SOFA score and FT3, TSH, FT4. The analysis of the ROC curve (low levels of FT3, FT4, TSH in plasma in patients on the last day of ECMO) indicates a prognostically unfavorable outcome. CONCLUSIONS: The moment of ECMO connection initiation is regarded as subacute phase critical illness. Along with a high level of plasma lactate and high score of SOFA scale, the level of decrease in FT3, FT4 and TSH in patients correlates with the lethal outcome. Low levels of TSH, FT4, and FT3 may be considered as a predictor of adverse outcome at the time of weaning/death on ECMO.
Formation of CuO$_2$ sublattices by suppression of interlattice correlations in tetragonal CuO
Authors: Bramberger Max , Bacq-Labreuil Benjamin , Grundner Martin , Biermann Silke , Schollwöck Ulrich , Paeckel Sebastian , Lenz Benjamin
Published: January 2023

We investigate the tetragonal phase of the binary transition metal
oxide CuO (t-CuO) within the context of cellular dynamical mean-field
theory. Due to its strong antiferromagnetic correlations and simple
structure, analysing the physics of t-CuO is of high interest as it may
pave the way towards a more complete understanding of high-temperature
superconductivity in hole-doped antiferromagnets. In this work we give a
formal justification for the weak-coupling assumption that has
previously been made for the interconnected sublattices within a single
layer of t-CuO by studying the non-local self-energies of the system. We
compute momentum-resolved spectral functions using a Matrix Product
State (MPS)-based impurity solver directly on the real axis, which does
not require any numerically ill-conditioned analytic continuation. The
agreement with photoemission spectroscopy indicates that a single-band
Hubbard model is sufficient to capture the material’s low energy
physics. We perform calculations on a range of different temperatures,
finding two magnetic regimes, for which we identify the driving
mechanism behind their respective insulating state. Finally, we show
that in the hole-doped regime the sublattice structure of t-CuO has
interesting consequences on the symmetry of the superconducting
state.
The history of the creation and publication of the first complete translation of the Elder Edda: To the 140th anniversary of the birth of S. A. Sviridova (Sviridenko)
Authors: Dorofeeva Elena
Published: January 2023

The article deals with the main works of the poet and translator Sofya Alexandrovna Sviridova (1882 — not earlier than 1928, pseudonyms S. Sviridenko, G. Sviridova), first of all, the history of the creation and first publication of the first complete translation into Russian of the Elder Edda (1910, 1st volume published in 1917), in a manuscript awarded the Academic Prize of M. N. Akhmatov. Archival materials found by the author of the publication shed light on some episodes from Sviridova’s biography, including the years of her studies at the St Petersburg Higher Women’s (Bestuzhev) Courses. The article deals with the episodes that influenced the life and creative destiny of Sophia Sviridova, such as, for example, acquaintance with Professor F. A. Brown, who became her teacher and then chief reviewer, collaborated with A. Blok, who systematically gave the translator a job at the “World Literature” publishing house. Particular attention is paid to the description of the second volume of the complete translation of the Old Norse epic Elder Edda, which to this day remains in the manuscript and is stored in the archive of the publisher M. V. Sabashnikov. This study can serve as a theoretical basis for the publication of the second volume of the translation of the Elder Edda by S. Sviridenko (Sviridova), or the publication of the entire work in one book — this is exactly how it seemed logical and correct to the translator herself. Hopefully some other works from the rich literary heritage of S. A. Sviridova will be published in the future.
A Quinquennial Review of Potent LSD1 Inhibitors Explored for the
Treatment of Different Cancers, with Special Focus on SAR Studies
Authors: Sheikh Khursheed Ahmad , Iqubal Ashif , Alam Mohammad Mumtaz , Akhter Mymoona , Khan Mohammad Ahmed , Ehtaishamul Haque Syed , Parvez Suhel , Jahangir Umar , Amir Mohammad , Khanna Suruchi , Shaquiquzzaman Mohammad
Published: January 2023

Cancer bears a significant share of global mortality. The enzyme Lysine Specific
Demethylase 1 (LSD1, also known as KDM1A), since its discovery in 2004, has
captured the attention of cancer researchers due to its overexpression in several cancers
like acute myeloid leukaemia (AML), solid tumours, etc. The Lysine Specific Demethylase
(LSD1) downregulation is reported to have an effect on cancer proliferation, migration,
and invasion. Therefore, research to discover safer and more potent LSD1 inhibitors
can pave the way for the development of better cancer therapeutics. These efforts have resulted
in the synthesis of many types of derivatives containing diverse structural nuclei.
The present manuscript describes the role of Lysine Specific Demethylase 1 (LSD1) in
carcinogenesis, reviews the LSD1 inhibitors explored in the past five years and discusses
their comprehensive structural activity characteristics apart from the thorough description
of LSD1. Besides, the potential challenges, opportunities, and future perspectives in
the development of LSD1 inhibitors are also discussed. The review suggests that tranylcypromine
derivatives are the most promising potent LSD1 inhibitors, followed by triazole
and pyrimidine derivatives with IC50 values in the nanomolar and sub-micromolar
range. A number of potent LSD1 inhibitors derived from natural sources like resveratrol,
protoberberine alkaloids, curcumin, etc. are also discussed. The structural-activity relationships
discussed in the manuscript can be exploited to design potent and relatively
safer LSD1 inhibitors as anticancer agents.
The Effect of Auriculotherapy During Active Phase and the Use of Oxytocin
During Labor in Nulliparous Women-A Randomized Clinical Trial
Authors: Vakilian Katayon , Ghaemmaghami Mehrnoosh , Sheikhganbari Narges , Shabani Fatemeh , Vahedi Masoomeh
Published: January 2023

Background:

Since there was no study on the effect of auriculotherapy on reducing the use
of oxytocin and labor length, the present study is aimed to investigate this issue.

Methods:

The present study was a randomized clinical trial with two parallel arms, without blinding,
which was performed on 93 nulliparous women. Setting this study was done in one of the referral hospitals
in Qom, Iran. The samples were randomly assigned to two groups: oxytocin (n = 47) or auriculotherapy
and oxytocin (n = 46). After hospitalization of mothers in the active phase, in one group, 10-
unit oxytocin was administered for augmentation, and in the second intervention group, the auriculotherapy
technique, in addition to oxytocin, was performed. the master points zero, Shenmen, endocrine,
thalamic, uterine, prostaglandin points, vagina on the earlobe area. The points were stimulated
with the Pointer Plus electric device for 30 seconds, and 60 minutes later, the other ear was stimulated.
The results were analyzed by SPSS 22, T-test statistical analysis, and Chi-square test.

Results:

Regarding the main purpose of the study, the results showed that the length of the active
phase indicated a significant decrease in the auriculotherapy group compared to the oxytocin group
(244.86 ± 64.19 vs. 284 ± 62.75, p = 0.01). The other purpose of the study showed that the mean of
oxytocin consumption significantly decreased in the auriculotherapy group.

Conclusion:

It seems that auriculotherapy is an appropriate alternative method for labor augmentation.
Fuad Fuad fuad: Thank you for reviewing the copyediting of your manuscript, "The Effectiveness and Distribution of Fishing Light Attractors on the Stationary Lift Net," for Research Journal of Life Science. We look forward to publishing this work. Aminatus Suhriyah Institute of Research and Community Service, University of Brawijaya riris.aminatus@ub.ac.id
Authors: Fuad Fuad , Primyastanto Mimit , Pranowo Doddy , Maulana Eka , Sari Wahida Kartika , Supriyadi Supriyadi
Published: January 2023

A stationary lift net requires an effective fishing light attractor. The intensity and distribution of light are important factors to increase the effectiveness of fishing light attractors. This study aimed to probe the distribution of light intensity and its effect on the effectiveness of fishing light attractors. This research employed a descriptive-comparative method by comparing the effectiveness of LED lights with kerosene lights. The results showed that the concentration of fish school in LED lights was at a depth of 4–10 m with a light intensity of 1x10-8– 10x10-8 W/cm2, while the kerosene lights was deeper than LED lights at a depth of 8–12 meters with a light intensity of 1x10-8– 10x10-8 W/cm2. The distribution of fish schools from LED lights tends to be concentrated and form larger schools than kerosene lights. The optimum light intensity of LED and kerosene lights was almost the same, in the range of 1x10-8– 10x10-8 W/cm2, with concentrations of fish schools reaching 65% and 64%, respectively. The total catch of LED lights fish during eight fishing trips was 168.5 kg or an average of 21.06±2.32 kg/trip, while the total catch of kerosene lights was 139.6 or an average of 17.5±1.98 kg/trip.
Social economic and education of national athletes
Authors: Mikdar Ujen Zenal , Ulfa Zuly Daima , Sugiyanto Roso
Published: January 2023

The success of becoming a national athlete cannot be separated from various aspects which influence it, they are internal aspects, coaching and training, social environment, family, education, sociocultural, and other factors. The purpose of this research is to identify the national athlete profiles from their socio-economic and educational aspects. This research was categorized into descriptive qualitative research involving eight participants from national athletes in Palangka Raya, Central Kalimantan. The results of the study showed that the social attitude of the athlete's achievements was due to their disciplines, high willpower, determination to win, self-confidence, fighting, hard work, perseverance, patience, and prayer. In addition, based on the economic aspects, the athletes have the opportunity to become civil servants; get some money, land lots, and a house; be more convenient to choose a school; and have the opportunity to go Hajj and travel abroad. The research also showed that most of them are high school graduates, some are still in college and some of them are college graduates. As national athletes, they must be able to manage the time between training and studying, especially when they are taking part in training camps and matches.
Effects of online learning on responsibility character of junior high school students in Yogyakarta
Authors: Saliman Saliman , Wijayanti Agustina Tri , Hartati Yumi
Published: January 2023

This study aims to confirm the results of online learning for junior high school students in Yogyakarta and to clarify the impact of online learning on the development of character values. This study uses a mixed method that combines qualitative and quantitative methods. The research data were obtained by distributing questionnaires to 44 students in 249 public schools. The data collected were tabulated and analyzed to determine the effects of online learning on the responsibility character of junior high school students in Yogyakarta. The results show that the R-squared value of 0.107 has an impact on liabilities of 10.7 so the remaining 89.3 liabilities are influenced by other variables not included in this survey model. Hypothesis test proves that t count 2,590 t-table 1,6725 count and significance 0.012 0 F-table 4.01 and significance 0.012 . 0.050. To conclude, online learning affects your sense of responsibility at the same time.
Promoting the urgency of restorative justice to environmental law enforcement officials through civic engagement education
Authors: Anggraeni Dewi , Amrullah Muhammad Karim
Published: January 2023

Although bringing cases of environmental damage to court means prioritizing the principle of primum remedium by way of retributive justice or criminal justice, it unfortunately creates various problems including the practice of corruption, collusion and nepotism. Therefore, it is necessary for law enforcement officials to understand and apply restorative justice in environmental crime, which means prioritizing the principle of ultimum remedium, through civic engagement education. This research method includes social research which also covers the field of law since it analyzes positive laws that are relevant to solving problems using literature and other sources as needed. This research uses a juridical-normative legal approach which is very dependent on the researcher's conception of positive law. The results of this study indicate that law enforcement officials should understand their position as part of the community members who have duties and authorities based on the law, so that justice and ecological goals can be achieved in efforts to preserve the environment.
Gastroenteritis Forecasting Assessing the Use of Web and Electronic Health Record Data With a Linear and a Nonlinear Approach: Comparison Study
Authors: Poirier Canelle , Bouzillé Guillaume , Bertaud Valérie , Cuggia Marc , Santillana Mauricio , Lavenu Audrey
Published: January 2023

Background

Disease surveillance systems capable of producing accurate real-time and short-term forecasts can help public health officials design timely public health interventions to mitigate the effects of disease outbreaks in affected populations. In France, existing clinic-based disease surveillance systems produce gastroenteritis activity information that lags real time by 1 to 3 weeks. This temporal data gap prevents public health officials from having a timely epidemiological characterization of this disease at any point in time and thus leads to the design of interventions that do not take into consideration the most recent changes in dynamics.

Objective

The goal of this study was to evaluate the feasibility of using internet search query trends and electronic health records to predict acute gastroenteritis (AG) incidence rates in near real time, at the national and regional scales, and for long-term forecasts (up to 10 weeks).

Methods

We present 2 different approaches (linear and nonlinear) that produce real-time estimates, short-term forecasts, and long-term forecasts of AG activity at 2 different spatial scales in France (national and regional). Both approaches leverage disparate data sources that include disease-related internet search activity, electronic health record data, and historical disease activity.

Results

Our results suggest that all data sources contribute to improving gastroenteritis surveillance for long-term forecasts with the prominent predictive power of historical data owing to the strong seasonal dynamics of this disease.

Conclusions

The methods we developed could help reduce the impact of the AG peak by making it possible to anticipate increased activity by up to 10 weeks.
Characterizing Heated Tobacco Products Marketing on Instagram: Observational Study
Authors: Chen Jiarui , Xue Siyu , Xie Zidian , Li Dongmei
Published: January 2023

Background

Heated tobacco products (HTPs), including I Quit Ordinary Smoking (IQOS), are new tobacco products that use an electronic device to heat compressed tobacco leaves to generate an aerosol for consumers to inhale. Marketing of HTPs is prevalent on Instagram, a popular social media platform.

Objective

This study aims to characterize posts related to HTPs on Instagram and their associations with user engagement.

Methods

Through the Instagram application programming interface, 979 Instagram posts were collected using keywords related to HTPs, such as “IQOS” and “heat-not-burn.” Among them, 596 posts were related to IQOS and other HTP marketing. The codebook was developed from a randomly selected 200 posts on the post content by hand coding, which was applied to the remaining 396 Instagram posts. Summary statistics were calculated, and statistical hypothesis testing was conducted to understand the popularity of Instagram posts on HTPs. Negative binomial regression models were applied to identify Instagram post characteristics associated with user engagement (eg, count).

Results

Among Instagram posts related to HTP marketing (N=596), “product display” was dominant (n=550, 92.28%), followed by “brand promotion” (n=41, 6.88%), and “others” (n=5, 0.84%). Among posts within “product display,” “device only” was the most popular (n=338, 61.45%), followed by “heatstick only” (n=80, 14.55%), “accessory” (n=66, 12%), “device and heatstick” (n=56, 10.18%), and “capsule” (n=10, 1.82%). A univariate negative binomial regression model with pairwise comparisons across “product display” types showed that the number of likes for posts with HTP heatsticks was significantly lower compared to posts with HTP devices, accessories, and device-heatstick sets. Multivariate negative binomial regression models showed that HTP-related Instagram posts with a model or lifestyle elements (;=.60, 95% CI 0.36-0.84) or without obvious product advertising information (=.69, 95% CI 0.49-0.89) received more likes.

Conclusions

It is shown that posts with product displays were dominant among HTP-related posts on Instagram. Posts with model or lifestyle elements are associated with high user engagement, which might be one of the web-based marketing strategies of HTPs.
Híbrido y mestizo, valores de una arquitectura contradogmática
Authors: Fuentes-Hernández Pablo , Cerda-Brintrup Gonzalo
Published: January 2023

The survey of social values associated with an unorthodox, liquid, elusive reality, where concepts such as the pure, the clear, and the perfect, have been overcome by the tensions of contemporary life, has led architectural dogma into a frank crisis for at least fifty years. Venturi was one of the first to reflect on this, associating it with a chromatic idea where gray settled on white or black. It was the end of the great stories of modern and already historic architecture. From then, the possibility that otherness, diversity, and difference were installed in the blurred spaces that architectural rationality had left without suture or closure.
El primer “Barrio Jardín” de Tucumán. Escenario de la evolución de la arquitectura y el urbanismo del siglo XX
Authors: Villavicencio Susana
Published: January 2023

This article addresses the study of the first neighborhood designed and financed by the Caja Popular de Ahorros, called Barrio Jardín and located in the city of San Miguel de Tucumán. Its recipients were the province's salespeople and industrial workers, who were given access to mortgages. This was the first response from the provincial entity for a low-income sector, to face the lack of housing. The housing development, inspired by the English garden city structure, transformed and applied to the garden suburb concept, had its architectural expression in the Californian chalet. The three extensions it underwent in subsequent decades followed the trends of the Modern Movement, both in terms of urban layout and its architecture. The research adopted a qualitative methodology, viewing the problem from a historical perspective. Although work began in the context of Juan Domingo Perón's first government (1946-1952), the extensions were made between 1962 and 1973, in other political and economic circumstances. The unit of analysis is limited to the first garden neighborhood of San Miguel de Tucumán, with its different stages of expansion, but the timeline covers the 1940s, 1960s, and 1970s. The goal of this article was to look through the urban–architectural lines applied in the different stages of the Garden Neighborhood's design, where urban land occupation and architecture were the product of the prevailing principles at their times.
"A los ojos de Santa Lucía: arte urbano y organización comunitaria en el Centro Histórico de San Salvador "
Authors: Rivera-García Sofía , Reyes-Schade Emilio
Published: January 2023

Urban art has been and continues to be a transforming component within urban renewal processes, reinforcing memory, recovering the sense of place, and reducing stigmatization. This article delves into the role of urban art within the (physical-spatial) requalification and (symbolic) resignification processes in Urban Working-Class Settlements, analyzing how these processes are related to strengthening place attachment, sense of belonging, sense of security, and community organization, and trying to reflect on how they can affect deeper lying issues such as social and environmental risk. The methodology used is participatory action research, which was developed with the Santa Lucía Community in the Historic Center of San Salvador. Although the limitations of urban art are clear in the face of complex problems such as urban violence and environmental risk, the case of Santa Lucía reflects the potential of these interventions when they emerge as a collective and consensual expression, becoming an instrument of citizen vindication, strengthening community ties and organization.
Villa CEREPEC-Chiguayante. Cooperativismo y vivienda colectiva en el Gran Concepción
Authors: Pérez-Bustamante Leonel , Morales-Marchant Marco , Cvitanic-Díaz Boris , Matus-Carrasco Daniel
Published: January 2023

The Metropolitan Area of Concepción (AMC) has industrial traces in its urban development. Under the auspices of state industries and their workers, housing complexes were developed in the second half of the twentieth century, away from industrial plants, proposing new modes of urban development for the period and location. A case in question is the Cooperativa de Empleados Refinería de Petróleo Concepción (Concepcion Petrol Refinery Employees Cooperative or CEREPEC), in Chiguayante. This article records part of the urban evolution of this commune, through the analysis of a housing complex materialized by workers of the National Petroleum Company (ENAP) under the cooperative model. The results show both the foundational contribution in building the urban space of "Manantiales street", as well as the way cooperativism materialized in the urban design and the architectural project of the CEREPEC complex. The company-worker-savings bank relationship stands out, where the worker assumes the leadership and the company supports its management, in a model that is very distant from industrial paternalism, and which logically builds different new sectors in the city. It is a relevant model because participatory processes are in demand today, involving the dynamics of construction and transformation of houses and neighborhoods.