bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethnomedicinal Value, Phytochemical Evaluation, and Pharmaco-Toxicological Profiling of Cipadessa Baccifera (Roth) Miq. among Communities of Bokod, Benguet
Authors:   herondsanchez@gmail.com, Benguet State University-Bokod Campus, Ambangeg, Daklan, Bokod, Benguet, Philippines, D. Sanchez Heronima
Published: January 2023

Cipadessa baccifera (Roth) Miq was studied for its traditional use, phytochemical properties, and pharmaco-toxicological properties. The descriptive qualitative method was used in this study to describe the traditional use of the medicinal plant, and the experimental quantitative method was used to determine the plant’s components and capabilities. Assays such as Thin Layer Chromatography (TLC), Chorioallantoic Membrane Assay (CAM), Brine Shrimp Assay, and Zebrafish Embryotoxicity Assay were done to profile the C. baccifera. Based on the results, traditionally, the plant parts were used as a treatment for diarrhea, toothache, cough, colds, indigestion, flu symptoms, dysmenorrhea, urinary tract infection, bleeding and swelling of gums, skin rashes, lowering blood sugar, dandruff, natural family planning, animal farm deworming and skin diseases. Its phytochemical contents include anthraquinones, anthrones, alkaloids, flavonoids, fatty acids, triterpenes, steroids, phenols, and essential oils. Furthermore, the CAM vascularity inhibition of Cipadessa baccifera concentrations increased with concentration, indicating that the inhibition of vascularity increased with concentration. Similarly, the brine shrimp cytotoxicity test revealed that the number of shrimp deaths increased as the concentration of plant extract increased. Furthermore, the plant extract’s calculated LC50 was 434ppm. Microscopic analysis of the zebrafish embryo exposed to the ethanolic extract of the plant sample, on the other hand, revealed malformation in the larvae exhibiting scoliosis at 100ppm extract concentration. Additionally, at plant extract concentrations ranging from 250ppm to 1000ppm, retarded and coagulated embryos were observed. Given the findings of the research study, it is highly recommended that future studies include the ecology and biology of C. baccifera in the Philippines to establish a further taxonomic classification of C. baccifera endemic to the country. Keywords: Pharmaco-toxicological properties, phytochemical analysis, CAM Assay, Embryotoxicity, Philippines
PROTEÇÃO SOCIAL E CRIANÇA: NOTAS SOBRE TRANSFERÊNCIA DE RENDA EM TEMPOS DE COVID-19
Authors: Rodrigues Jovina Moreira Sérvulo , Joazeiro Edna Maria Goulart
Published: January 2023

O presente artigo aborda o sistema brasileiro de proteção social não contributivo, notadamente, pelo viés da transferência de renda, como ação integrante das intervenções do Sistema Único de Assistência Social - SUAS e seus impactos no cotidiano das crianças oriundas de famílias vulneráveis. Trata-se de uma discussão que se encontra em pauta na atual conjuntura, posto que a ascensão do sistema capitalista neoliberal, com seus efeitos deletérios, já vinham promovendo o recrudescimento das vulnerabilidades sociais e que, a partir da crise sanitária da Covid-19, a ampliação do quadro de desigualdades sociais  tornou-se mais evidente desafiando a política da assistência social, por meio dos programas de transferência de renda, que se tornaram instrumento basilar de combate à pobreza e de redução das vulnerabilidades e desigualdades, a dar respostas concretas aos segmentos pauperizados numa realidade cujas condições de sobrevivência estão cada vez mais complexas.
IDENTIFICAÇÃO DE FADIGA POR COMPAIXÃO EM ENFERMEIROS DE UM HOSPITAL ONCOLÓGICO
Authors: Toebe Thayla Rafaella Pasa , Constant Hilda Maria Rodrigues Moleda , Brandão Mayara Lindner , Da Silva Giovani Basso , Medeiros João Gabriel Toledo , Rabin Eliane Goldberg
Published: January 2023

Identificar a Fadiga por Compaixão entre os enfermeiros de um Hospital Oncológico e suas associações com as variáveis sociodemográficas elencando segundo os participantes os motivos responsáveis para a ocorrência da Fadiga por Compaixão. Estudo transversal com utilização de questionário sobre dados sociodemográficos, quarta versão da Escala de Qualidade de Vida Profissional (ProQol-IV) e questão exploratória sobre os motivos responsáveis para a ocorrência da fadiga por compaixão. A amostra foi constituída por 29 enfermeiros e demonstrou alto nível de Satisfação por Compaixão, baixo nível de Fadiga por Compaixão e moderado nível de Burnout, As variáveis sociodemográficas não apresentaram correlações significativas com as subescalas da ProQol-IV e os três motivos mais mencionados para a ocorrência da Fadiga por Compaixão foram sobrecarga de trabalho, a perda do paciente e o contato com o sofrimento do paciente e familiares. Os níveis encontrados nas três subescalas são conhecidos como a melhor combinação, sugerindo que os profissionais possuem estratégias para enfrentar o sofrimento e os estressores vivenciados.
SÍNDROME DE CUSHING IATROGÊNICA
Authors: Salgado João Paulo Soares , Mansur Fernanda Dorado , Gotardelo Daniel Riani
Published: January 2023

Os glicocorticoides (GC) exógenos foram introduzidos na prática médica por simularem a ação endógena do cortisol, o principal corticoide endógeno. Somado aos seus benefícios, os GC exógenos têm seu uso e venda permitidos sem a necessidade de retenção de receita médica e, por responderem bem a diversas patologias, os pacientes os utilizam por longos períodos, sem conhecerem os riscos que trazem para a saúde. O uso indiscriminado de GC apresenta um perfil muito extenso de efeitos adversos, alguns esteticamente indesejáveis e outros graves. A Síndrome de Cushing Iatrogênica (SCI) é uma desordem provocada pelo uso excessivo ou prolongado de corticosteroides. A causa mais comum da SCI é a ingestão de prednisona, geralmente para o tratamento de uma doença não endócrina. Os GC agem sobre o hipotálamo e hipófise anterior inibindo a liberação de ACTH (hormônio adrenocorticotrófico) levando a uma inibição da função adrenal, em um processo conhecido como feedback ou retroalimentação negativa. Além disso, os GC alteram de forma importante o metabolismo ósseo, impedem a absorção e aumentam a excreção renal de cálcio, além de causar problemas no funcionamento dos demais sistemas do organismo, interferindo no controle do humor, na resposta imunológica e no metabolismo de carboidratos, lipídios e proteínas. O diagnóstico da SCI é sugerido por alguns achados, entre sinais e sintomas, e em sua grande maioria é apenas clínico e não é necessária a confirmação por testes bioquímicos. O manejo dessa patologia tem como objetivo minimizar a exposição aos glicocorticoides, além de certas medidas para amenizar seus efeitos indesejáveis. O presente trabalho tem como objetivo abordar a SCI em seus aspectos fisiopatológicos, clínicos e laboratoriais, além de discutir o seu manejo por meio de medidas farmacológicas e não-farmacológicas.
FINANÇAS PÚBLICAS MUNICIPAIS REVISITADAS: UMA ANÁLISE DA INFLUÊNCIA INSTITUCIONAL DA LEI DE RESPONSABILIDADE FISCAL (LRF)ANTES E APÓS A CRISE DE 2008
Authors: Silva William Gledson e , Souza José Antônio Nunes de , Ferreira Francisco Danilo da Silva
Published: January 2023

Este artigo teve o objetivo de discutir as finanças públicas municipais da Bahia (BA), Rio Grande do Norte (RN) e Piauí (PI), particularmente, a relação de alguns tipos de recursos diante da Receita Corrente Líquida (RCL) e determinados gastos frente à Despesa Corrente (DC) antes e após a crise de 2008, de como a aferir a influência da Lei de Responsabilidade Fiscal antes e após a crise do mesmo ano. Metodologicamente, foi usado uma revisão de literatura e o instrumento da econometria ligado aos dados em painel estático. Os resultados principais da pesquisa mostraram que houve relativa piora fiscal após 2008, com queda na repercussão de algumas rubricas de recursos, além da redução mais flagrante nos investimentos no mesmo período, conservando os gastos com funcionalismo, os mais representativos na integralidade dos entes examinados.
Estimation of low salinity water flooding efficiency to improve oil recovery in sandstone reservoir in Kazakhstan
Authors: Askarova Ingkar A. , Uteyev Rahim N. , Mardanov Altynbek S. , Jaxylykov Talgat S. , Junusbayeva Ainura U.
Published: January 2023

Background: The regular increase in demand for hydrocarbons necessitates the introduction of optimal technologies to improve the development of reserves. The method of utilization of water with low salinity as an injected agent seemed promising in solving this issue.

Aim: The aim of this article is to assess the potential of low-salt water to increase production and oil recovery in the terrigenous field of Kazakhstan.

Materials and methods: For the study, low-salinity water injection into the reservoir was simulated on the ECLIPSE 100 simulator. The impact of salt concentration on production and oil displacement efficiency in the considered field during the secondary injection were determined by simulating flooding of solutions with different salinity. The model has been running for 18 years. Analysis of salinity reduction efficiency was carried out by comparing oil recovery after flooding with high salinity water.

Results: The decrease in water salinity led to an increase in oil recovery by 1.32%. Such a slight increase in production is due to the initial hydrophilic properties of the rock. To obtain a response from the contact of low-salt water with rock, the presence of adsorbed oil on the surface of minerals is required. It can be said with high probability that in this reservoir, an increase in the oil recovery factor with a decrease in salinity is due to active interactions at the oil-water interface, one of which is an increase in viscoelastic properties.

Conclusion: A slight difference in the efficiency of oil displacement between the studied low-salinity waters indicates the presence of the optimal salinity of the injected water. The initial hydrophilic property of the reservoir rock surface excludes wettability change as a reason for the increase in oil production. Further study of low-salt water flooding on core material from the studied field is recommended to obtain accurate data and understand how low salinity can affect the distribution of oil in the rock.
Peculiarities of identifying reservoirs with high radioactivity according to well logging data
Authors: Zhamalidenova Gulzhamal T. , Jumagalieva Ainagul K.
Published: January 2023

This article discusses the peculiarities of identifying reservoirs with high radioactivity based on geophysical research materials, the integrated approach used in interpreting research and analyzing geological and geophysical material using the example of Cretaceous and Jurassic deposits of the South Western Kamyshitovoye, Botakhan, Nuraly fields.

The aim of the work is to study the distribution of highly radioactive productive reservoir rocks, substantiate the causes of their occurrence and the relationship with lithological differences of sedimentary facies.
Research of the impact of switching to low- salinity water during polymer water flooding
Authors: ABIROV Zhandos Zh. , Abirov Rustem , Sahuc Bertrand , Gil Ludwig , Divers Thomas
Published: January 2023

Background: Increasing the efficiency of a polymer flooding project, both technologically and economically, is always relevant.

Aim: This paper aims to consider switching to less saline water as a fairly simple and effective way to increase the effectiveness of a polymer flooding project.

Materials and methods: The work used data from a real polymer flooding project.

Results: As a result, we have been able to significantly reduce polymer consumption and improve pumping efficiency.

Conclusion: This work shows that, with the possibility of using less saline water, as a simple and effective way to reduce costs and increase efficiency, rolling polymer flooding.
The indicator study role in determining path of motion of formation fluids in the development of a fractured reservoir field
Authors: Kodar Bakhytgul K. , Assanov Karim B. , Mukhtanov Bakhytzhan M. , Urymbassarov Rustem D. , Mardanov Altynbek  S.
Published: January 2023

The high rate of oil production with the use of water flooding, complex geological and physical conditions of the carbonate reservoir of the deposit (fractures, faults) lead to progressive watering of the extracted products.

The field has considerable oil reserves and is at the development stage II, the average water cut is more than 60%, most of the remaining reserves pass into reserves difficult to recover category. This article focuses on determining relations between blocks and practical application of the results of indicator study method in order to determine the porosity and permeability properties of fractured carbonate formations. According to this study method, the introduction of complementary technologies to improve the existing development system was proposed.
A pragmatic approach to polymer flooding to accelerate field implementation
Authors: Thomas Antoine
Published: January 2023

Background: Polymer flooding is a well-known enhanced oil recovery technique which can increase recovery factors in mature oilfields above 10% of the oil originally in place. Despite a lengthy history and many published field cases, the speed of deployment is still rather slow. With the need to boost energy production while minimizing energy wastes and carbon emissions, considering this technique known to reduce water usage and accelerate oil recovery should be a must.
Aim: This short publication aims at providing guidelines to accelerate deployment of polymer injection in various oilfields and a couple of pragmatic approaches recognizing the need for field data instead of poorly constrained simulations or incomplete laboratory studies.
Materials and methods: After a brief review of the technique and current implementation workflows, we will discuss new approaches to foster the deployment of injection pilots by showing how polymer injection can reduce emissions and energy wastes while accelerating oil production.
Results: We provide a different perspective on polymer injection with pragmatic tools and ideas showing that going to the field fast provides more information than any laboratory study.
Conclusion: Given the current need for mitigating oil production declines, polymer flooding is a technique of choice which can be deployed fast if basic criteria explained in this paper are met.
Decentering Colonialism and Ableism in Artistic Practices
Authors: Kallio-Tavin Mira , Wexler Alice
Published: January 2023

This article introduces the work of five young disabled artists, creative workers, and scholars of color, who the authors invited to be on a panel titled Decentering Colonialism and Ableism in Artistic Practices at the 3rd International Conference on Disability Studies, Arts, and Education. In this article, we focus on three intersecting and interconnected themes that were discussed during the panel: crip time/wisdom, colonialism, and care. The artists work against colonial knowledge through lived experiences and desires that resist ableist, white, and normative structures. The power of artmaking materializes ideas through their bodies, writings, performances, and images through multiple media and technologies that elucidate the disabled bodymind conditions. The authors acknowledge how differently the pandemic allowed care to be offered for disabled, queer, Black, Indigenous, and people of color (BIPOC), particularly considering how black and brown people often provide the networks of care. We argue that the intersecting themes of crip time, colonialism, and care are significant for human ethical values and social justice.
Disability Justice Praxis: Sick, Disabled, Deaf Women and Non-Binary Educators of Color Holding Each Other in Radical Love and Accessible Kinship
Authors: Acevedo Sara M. , Yoshizaki Hailee M. , Abustan Paulina , Pearson Holly
Published: January 2023

Academic spaces in the United States remain exclusive and toxic for those who embody multiple marginalized identities. There is hope, however, as subversive practices and resistance to systemic oppression and hostility continue to infiltrate academia through the work of socially engaged scholar-activists. In this paper, we—four sick, disabled, and Deaf women and non-binary educators of color—come together to discuss our paths to understanding ourselves and our places within academia. Through the methodology of activist ethnography, we explore the diverse and complex ways we embrace Disability Justice in our teaching, research, scholarship, and activism. Collectively and through interwoven storytelling, we disrupt and challenge ableism, racism, settler colonialism, cis-hetero-sexism, classism, and other intersecting forms of oppression within academia by (re)centering and amplifying our lived experiences and disabled, Deaf, and chronically ill epistemologies. Simultaneously, through a Disability Justice praxis, we work to imagine and create educational spaces that build and support radical love, accessible kinship, and healing.
Decolonizing Relaxed Performance: A Visual Translation of Vital Ecosystems
Authors: Collins Kimberlee , Temple Jones Chelsea , Rice Carla
Published: January 2023

This essay draws on the visual translations produced by artist Sonny Bean in response to the 2022 report, Relaxed Performance: Exploring University-based Training Across Fashion, Theatre and Choir. Relaxed performance (RP) is a wide-reaching movement toward accessibility in arts that challenges normative comportment in performance contexts and has evolved into a contemporary cross-sector vital practice rooted in disability justice. Through a selection of illustrations, Bean transforms human-centric data about RPs into a vital ecosystem that extends to the more-than-human world, denoting the complex interconnectedness of RP production in a settler colonial state.
Book Review: Eco Soma: Pain and Joy in Speculative Performance Encounters, Petra Kuppers
Authors: Hoppe Erin J.
Published: January 2023

This book review considers Petra Kuppers’s (2022) most recent book, Eco Soma: Pain and Joy in Speculative Performance Encounters. In this accessible text, Kuppers describes a method, eco soma, for ethical, relational being with the world, each other, and ourselves. Like dance, water, and bodies, the eco soma method is unfixed and calls for audience engagement, grounded in somatics, performance art, and disability culture. Working to take eco soma and this book’s arrangement to heart and practice, this review considers lineages and provides glimpses of the encounters described within, which are woven with experiences and myriad theoretical tentacles. It concludes by echoing Kuppers’s call for un/bounding disciplines.
The Fibonacci Sequence and Numbers
Authors:   Ananya Institute of science, Kirc campus Kalol, Patel Sneha B
Published: January 2023

The Fibonacci sequence is one of the most beautiful and febulas mathematical concepts. The Number is sequence turn in place that you have probably seen nature. The Fibonacci sequence is a series of numbers the follows a unique integers sequence. These numbers generate mathematical patterns that can be found in all real life. The Fibonacci numbers are also called the golden ratio. The golden section is used for architect, art, Space exploration, etc. Keywords: Fibonacci Numbers, Golden ratio
CASE SELECTION AND DATA DESCRIPTION FOR THE WORKING LABOURS IN A RESIDENTIAL BUILDING
Authors:   RVS Technical Campus, Coimbatore, Tamil Nadu, India -  641402., Prabaharan D , Bhuvaneswari Dr.D
Published: January 2023

Nowadays, many construction companies are facing with ever stricter environmental impacts and changing, innovative material markets in which customers are being increasingly aware of environmental impacts. In today's societies the built environment accounts for 10% of global economic, activity, consumes 40% of the world's material and energy production, accounts for 70% of the fresh water consumption and uses 25% of the annual global wood harvest. As we know, the construction of a building consisting of many activities that begins with Earthwork and ends with handover of the building to the customer by the contractor. Hence it includes many different construction materials which cause great impacts to the environment. Not only the building materials, but also the pollution producing during the period of construction and demolition of a building creates largest impact to the surrounding environment.
Inventario de recursos forestales del área de intervención de la concesión minera no metálica en Otavalo, provincia Imbabura
Authors: Valencia Valenzuela Xavier Germán , Rosero Chamorro Edwin Guillermo , Yépez Duque Edison Santiago , Jaramillo Vallejos Jimmy Raúl
Published: January 2023

La Concesión Minera para minerales no metálicos tiene una superficie de 75,00 ha., obtuvo su título el 26 de abril del 2010, posee un área de intervención 24,49 ha. Se ubica en la provincia Imbabura, cantón Otavalo, parroquia San José de Quichinche. El objetivo del presente estudio fue evaluar el recurso forestal del área de intervención de la Concesión Minera no metálica en el cantón Otavalo. La metodología aplicada fue mediante un censo forestal de todos los árboles con DAP igual o mayor a 10 cm. y se registró el DAP, altura comercial y altura total; además se determinó el volumen total, el área basal y se describió la estructura horizontal y vertical de los árboles. Los resultados muestran un área basal de 1,75 m2/ha., un volumen total de 497,02 m³ de madera en pie, el cual corresponde a 20,29 m³/ha., se registró 1.567 individuos, que equivale a 64 árboles/ha., siendo el eucalipto la especie que presentó el mayor Índice de Valor de Importancia (IVI) con 171,14%. Las especies registradas en el área son: eucalipto (Eucalyptus globulus), aliso (Alnus acuminata), leucaena (Leucaena leucocephala), ciprés (Cupressus lusitánica) y acacia (Acacia melanoxylon). En conclusión, el área de intervención presenta una cobertura de árboles plantados de edades diferentes, por lo que no aplica ningún valor económico por concepto de aportes totales por bienes y servicios de la biodiversidad; el eucalipto es la especie forestal más dominante y con el mayor IVI del área.
NANOTECHNOLOGY IN PLANT DISEASE MANAGEMENT - AN OVERVIEW
Authors: Padmavathi Saripalli , Satya Anuradha Chippada
Published: January 2023

Generally, advancements in various branches of science and technology have had a significant impact on various aspects ofplant pathology like efficient pathogen detection. Nanotechnology is found to have many applications of which plantpathology is the one important field. In recent years, nanotechnology has been increasingly applied to the development ofnovel antimicrobials for the management of pathogenic bacteria affecting agricultural crops. This review discusses theapplications of different nanoparticles in plant disease management and their mode of action against the bacteria. Thesynthesis of nanoparticles (NPs) using biomolecules (protein, enzyme, DNA and plant extracts) have opened a newavenue of research in green nanobiotechnology. They are proved to be effective, cheap and eco-friendly in combatingmicrobes. Reactive oxygen species production, lipid peroxidation, protein oxidation, ATP depletion and DNAdegradation are some of the mechanisms by which nanomaterials used to kill bacteria.
FFECTIVENESS OF SIMULATION-BASED LEARNING REGARDING MANAGEMENT OF POSTPARTUM HEMORRHAGE (PPH) IN TERMS OF COMPETENCIES AMONG NURSING STUDENTS IN SELECTED NURSING COLLEGES OF AMBALA, HARYANA
Authors: Kamboj Neha , Deaver Uma , Siddiqui Adiba , Sarin Jyoti
Published: January 2023

Postpartum Hemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide and isresponsible for about a quarter of all maternal deaths. The aim of the study was to assess the effectiveness of simulationbasedlearning regarding management of PPH in terms of competencies among nursing students in selected nursingcolleges of Haryana. Quasi- experimental design was adopted to assess the effectiveness of simulation based learning interms of competency of nursing students. Data was collected from 109 students studying in BSc. 4th Year in M.M.College of Nursing and M.M. Institute of Nursing. Purposive sampling technique was used to randomly allocate theparticipants in experimental and comparison group. The study findings showed that majority (76.7%) and (73.5%) of thenursing students were female in experimental and comparison group respectively. In experimental group, the mean posttestknowledge score (23.7 ± 4.1) and (22.3 ± 4.2) was higher than the comparison group. The mean post-test skillsscore (27.2 ± 4.3) in experimental group was higher than (24.7 ± 5.3) in comparison group. The mean post-test CDMAscore (12.7±2.1) in comparison group was higher than the mean post-test CDMA score (9.6±2.5) in experimentalgroup. The calculated ‘t’ value post-test skills scores (t=2.65; p=0.00*) which was found to be statistically significant at0.05 level of significance. The study concluded that Simulation based learning was effective in enhancing the competencyof nursing students regarding management of PPH.
CHARACTERIZATION OF MARINE ACTINOMYCETES SPECIES ISOLATED FROM AZHIMALA COASTAL REGION, KERALA AND IT’S EFFICACY AGAINST UROPATHOGENIC BACTERIA
Authors: Smith V. Robin Perinba , Mathew P Deepa
Published: January 2023

Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic applications and hold aprominent position due to their diversity and proven ability to produce novel bioactive compounds. The present study isaimed to prove the antagonistic activity of marine actinomycetes against uropathogens. 13 marine actinomycetes wereisolated from various marine sediment samples collected from different stations in the Azhimala coastal region, part ofthe Arabian Sea on the western coast of India. The sample collection and isolation of actinomycetes were done byfollowing the standard microbiological methods and the isolated colonies were characterized based on theirmorphological parameters. The morphologically distinct 13 isolates obtained in the present study, the isolates SD65,SD66, SD67, SD68, SD69, SD70, SD71, V66, V67, V68, V69,V70,V71 among them 3 isolates,V67,V68 and V70showed significant antagonism against selected uropathogens collected from a tertiary care center inThiruvananthapuram, Kerala. The results were promising and indicated that actinomycetes with distinctive biologicalactivity are abundant in the marine environment along Kerala's coast.
EVALUATION OF THE IMPACT OF GREEN TEA PLANT EXTRACT ON INTESTINAL ABSORPTION OF ASPIRIN USING EVERTED SAC TECHNIQUE
Authors: M. Kadam Ankita , N. Jagtap Pradnya , K. Musale Sumit , P. More Vaishnavi , S. Bobade Shweta , P. Deshmukh Pratibha , D. Pol Komal , M. Kunjir Ashwini
Published: January 2023

In vivo Absorption investigations are time-consuming and expensive in order to find the best medication formulation.Models were employed to research drug permeability and dissolution in order to streamline the search for arecommended formulation. One example of an in vitro model is the use of a goat intestinal section (sac) to assess theabsorption of related drugs prior to formulation and clinical investigations. The investigation of excipient and additiveeffects on drug permeability is an intriguing use of this method. In this paper, the impact of epigallocatechin -3-gallate(EGCG), on the intestinal penetration of acetyl salicylic acid was investigated. When Aspirin was kept with green plantextract, the concentration of absorbed Aspirin was 12, 32 ,45, 49 and 51μg/ml after 15, 30, 45, 60 and 75 minrespectively; whereas 14 ,16 ,17 ,18 and 23 μg/ml of Aspirin was absorbed when kept alone. The study clearly showedthat the green tea extract enhances the absorption of Aspirin from goat intestine and this absorption enhancement activityof the plant is due to polyphenolic content, presence of polyphenols like catechins and epicatechins.
SYNTHESIS, CHARACTERIZATION AND ANTI-TUBERCULAR ACTIVITY OF 1, 3- THIAZINE DERIVATIVES
Authors: Bansal Hemant Kumar , Daniel Kratika , Jain Neetesh
Published: January 2023

Due to their potent biological activity, heterocyclic compounds have been used extensively in pharmacological research.Researchers' interest has been drawn to the heterocyclic molecule thiazine, which has four carbon atoms, one nitrogenatom, and one sulphur atom. It has interesting pharmacological properties. In the present work, a series of new thiazinederivatives were synthesized from substituted chalcone derivatives. Starting material was acetophenone derivatives. Thestructures of these compounds were confirmed by IR, NMR, Mass and elemental analysis. The synthesized compounds(IVa-IVe) were screened for anti-tuberculosis activity against Mycobacterium tuberculosis and the results show that some ofthese derivatives possess good activity against Mycobacterium tuberculosis.
ZEBRAFISH AS AN EMERGING ALTERNATIVE TOOL FOR STUDYING ANXIETY DISORDERS
Authors: War Radami , V Surendra , Paul Sukanya , Sharma Uday Raj , J Suresh , PM Manjunatha
Published: January 2023

Zebrafish are increasingly becoming popular as promising new model species for translational research in a variety of neurological fields. Because of their complex behaviors across all major neurobehavioral domains and strong genetic and physiological similarities to humans, zebrafish are well-suited to modelling many aspects of anxiety-related states. In this paper, we first summarized the behavioral models available in zebrafish, such as novel tank test, light/dark box test, open field test, and social preference test, and their efficacy in discovering anxiety-like indices in zebrafish, followed by highlighting the key neurotransmitter systems, such as glutamate and GABA. In addition, cortisol levels and gene expression were explored as well. Overall, this review discusses the benefits of using the zebrafish model for anxiety research and examines current research in the field.
SPHERICAL CRYSTALLIZATION: A TOOL TO IMPROVE SOLUBILITY OF DRUGS
Authors: B Hema Latha , E Manisha , G Harshavardhini , P Hyma
Published: January 2023

Spherical crystallization is a technique in which crystallization and agglomeration are carried out synchronously in one step to form compact spherical form. The most common methods used in spherical agglomeration are quasi emulsion solvent diffusion method, ammonia diffusion system, neutralization technique and co-agglomeration. It succeeded to improve dissolution property of poorly soluble drugs. This can change drug powder properties such as flowability, wettability, packability, compressibility. It has wider applications in improvement of poorly compressible drugs; it has wider application in improvement of compressability of poorly compressible drugs, masking bitter taste of drugs, improving dissolution property, bioavailability and solubility of drugs. Agglomeration crystals converted into tablet forms thus helping us by saving time and reducing cost.
ASSESSMENT OF FLUID INTAKE IN UROLITHIASIS PATIENTS ATTENDING UROLOGY CLINIC AT A TERTIARY CARE CENTERIN NORTH KARNATAKA
Authors: Sangolli Akshata . , Nerli Rajendra B , Ghagane Shridhar C
Published: January 2023

Urolithiasis is a highly prevalent disease all over the world. The prevalence of kidney stone disease in India is around 12%. Fluid intake is one of the important modifiable risk factors in kidney stone disease which can be considered for preventive measures. Nevertheless, various kinds of fluids cannot have the same effect on stone formation. North Karnataka region is more prone to stone formation due to a lack of fluid intake in several parts. We aim to assess the intake of various fluids and beverages along with water in urolithiasis patients attending the urology clinic at the tertiary care centre. A total of 240 kidney stone patients attending a urology clinic at a tertiary care centre were enrolled for the study between the period of 2020 to 2021. Structured and validated questionnaires comprising detailed information about brief medical history, lifestyle habits and fluid intake habits were provided to the subjects. Kidney stones were collected from all 240 patients to analyse the chemical composition and spectral studies. Out of 240 patients, 152 were male patients and 88 were females. The overall male-to-female ratio was 1.72: 1. The mean Body Mass Index (BMI) of all the patients was 25.83. The highest numbers of cases (43.3%) were seen in the age group above 50. Around 65.8% of cases used to consume less than an adequate amount of water. In stone analysis, 58.3% were calcium oxalates and 16.6% were uric acid stones which was the second-highest among cases. Fluids like milk, tea, and fruit juices are shown to reduce the risk of stone formation to some extent whereas less water intake was a major risk factor. Alcohol and aerated beverages are still having controversial results in stone formation. So, more studies have to be conducted in different geographic regions which may help to prevent the reoccurrence and may reduce the burden of urolithiasis.
FABRICATION OF NANO-STRUCTURED SURFACES BY FINE TUNING OF DEPOSITION PARAMETERS IN CHITOSAN/PSS POLYELECTROLYTE MULTILAYERS
Authors: Mathew Jissy .
Published: January 2023

The fabrication of chitosan/polystyrene sulfonate (CHI)/(PSS) polyelectrolyte multilayer on different polymeric supports (polyether sulfone, polycarbonate and nylon), is discussed in the present work. The permeation of model protein BSA through these multilayer membranes was carried out under ultrafiltration conditions. Different multilayer systems were prepared by varying the parameters such as nature of the polymeric support, pH and molecular weight of polyelectrolyte. Build up of multilayers on polymeric support was monitored by measuring area under the sulfonate peak at 1033 cm-1 in the FTIR spectrum. No appreciable rejection of BSA was observed when CHI/PSS multilayers were fabricated on polycarbonate and nylon supports even after 15 bilayer coating. When multilayers were fabricated on polyether sulfone membranes, more than 90% rejection of BSA was observed with 5 bilayer coated membrane. This study reveals that pH and molecular weight of the polyelectrolyte has decisive role in the multilayer build up.
GC- MS SCREENING AND IN-SILICO PREDICTION OF PILA GLOBOSA EXTRACT AGAINST THE BONE DISEASES IN CALCITONIN RECEPTOR
Authors: Pandirajan Shanmugam . , Samuel Shila . , Iswaran Vasumathi  . , Venkatachalam Rama Subramanian
Published: January 2023

India’s flora and fauna has diverse medicinal properties and constitutes the major portion of our traditional medicine system. One among them is snails. Snails have a long history of being used for treating diseases in traditional medicinal systems around the world including India and China. Pila globosa is one of the largest land snails, mainly used as food. Here in this study, the gas chromatography and mass spectrometry discovered the presence of thirteen bio active constituents with various medicinal applications. The constituent Stigmasta-4, 22-dien-3-beta-ol had the highest retention time and exhibited a efficient binding with the human protein calcitonin receptor ectodomain. The calcitonin receptor types is expressed widely in various tissues and cells but most importantly in the osteoclates and hence a very important receptor in the treatment for bone disorders. The binding of the Pila globosa snail constituent with the human calcitonin receptor proved that a novel drug can be developed from the snail for the treatment of bone disorders such as osteoporosis, hypercalcemia of malignancy and paget’s disease. In addition to that, the snail extract exhibited no cytotoxicity and an efficient antioxidant property against DPPH and H2O2 free radicals. The FTIR analysis revealed the snail contained biologically significant functional groups with properties suitable for a drug and prevalent in most of the pharmaceutical drugs. Thus, these results imply the safety and efficacy of the snail Pila globosa for a novel drug development.
MICROPROPAGATION OF PHARMACEUTICAL CROP RUBIA CORDIFOLIA
Authors: M Devi  Priya , Siril E. A. .
Published: January 2023

Plants are cherished as the chief resource for healthcare products attributed to synthesizing diverse array of bio-molecules through various metabolic alterations. Over exploitation of such resources can intimidate its existence. Developing medicinal plants into crops and the use of micropropagation as technique to mass produce high-demand biomass can make a continuous supply of natural therapeutic products. Rubia cordifolia is one such plant, so an improved, efficient, reproducible and reliable in vitro clonal propagation protocol is to be adopted for the conservation of germplasm. MS medium fortified with phytohormons viz., BA, Kin, 2-iP, TDZ, mT, IAA, IBA and NAA singly or in combinations were used for the study. After one month of inoculation, 2.5 μM of BA and TDZ (9.37) endorsed the instigation of multiple shoots through axillary bud proliferation in a short span of time. In vitro produced microshoots were subjected to ex vitro rooting by treating 2.5 mM IBA for 5 min and planting in plastic pots containing potting mixture, to produce maximum rooting (79.17%) response. It was found to be an efficient and effective mode of rooting, since it combines both hardening and rooting. Under green house condition, all the rooted plantlets showed more than 90% survival. So direct regeneration protocol from nodal explants without the intervention of callus and thus ensure production of clonally uniform plants of R. cordifolia.
AVALIAÇÃO DOS REFLEXOS PRIMITIVOS NO LACTENTE COMO FORMA DE DETECTAR A EXISTÊNCIA DE PATOLOGIAS NEUROLÓGICAS
Authors: da Silva Natália Rodrigues , de Arruda Eder Ferreira , Farias Ellen Polyana Carvalho , da Silva Gabriela Gomes , Ramos Giovanna Silva , Ferreira Jair José de Barros , Felinto Jaqueline de Oliveira Santos , Pinheiro Katia Rosa , Cardoso Maraysa Costa Vieira , de Sousa Stefhani Medeiros , de Araújo Caroline Marinho , Lima Edilberto da Silva , Medeiros Flaviane da Cunha , e Silva Larissa Gabriele Farias , Galdino Lívia Ferreira Cirilo
Published: January 2023

SEM RESUMO
Review: Dietary Intake and Type 2 Diabetes
Authors: Nweze Chibuzo Carole , Bisola Adedipe Lateefat , Ifeanacho Nwefia Wilson , Ekpe Ini Patrick
Published: January 2023

Diabetes occurs as a result of deficient insulin or inability of the body to make use of insulin effectively. Some range of dietary interventions can provide useful approaches for managing people with type 2 diabetes, including the regulation of blood glucose and lipid parameters, and for reducing the risks of acute and chronic diabetic complications. Dietary intake is measured to assess food, nutrient, or bioactive intake of individuals, groups, or populations. The purpose of collection of measurements varies from individual assessments in clinical situations or the adequacy of intake of population groups to use in research, relating diet to health status. Dietary intake measurement also determines daily eating pattern of an individual including specific foods and calories consumed and relative quantities. The role of vitamin D diet in glucose homeostasis is associated with insulin secretion, insulin resistance, and systemic inflammation and this is one of its important nonskeletal functions. In addition, there is a link between the consumption of dairy products and a lower risk of type 2 diabetic. Moreover, a low glycemic index (GI) diet is more effective in controlling glycated hemoglobin and fasting blood glucose than a high GI diet in patients with type 2 diabetes. Nutritional approaches employed in managing patients with type 2 diabetic may also involve the use of enteral nutrition, including oral nutritional supplements (ONS). In conclusion, in order to reduce the problems of diabetes, lifestyle changes usually dietary interventions, are adopted.
Pre-Historic Intra-Continental Africa-India Proximity Series on VedicPeriod-Earth: A Function of PANS-Domain and OMLAR-Codomain
Authors: Rao Rojukurthi Sudhakar
Published: January 2023

This is study of Africa-India Proximity on the Vedic-period-Earth by means of the specific knowledge of the Greek word Pan with implied sense of All/Entire/Whole. No wonder, Pan alone counts on the Vedic Universe of OMLAR (Ocean, Mountain, Land, Atmosphere, Rock) giving rise to the irrevocable four Pans’ Panthalassa, Pantheism, Pangaea and Pangenesis. Also, it accounts for all continental Geographies / Humans / Creatures for Proximity Series in research lookout. Proximity Series’ insight is escalated viewing from all-inclusive-breathed-out Vedic Knowledge elevating Earth as Super Vedic Conceptacle (SVC) bringing into play exponential power of Pan for material comprehension. Overall, the crux of matter is four Pans being invokers of SVC which functions as the many-one relationship between Pan’s domain of above four irrevocables and OMLAR-codomain.
Power Quality Improvement by Reduction of Harmonic using Shunt Active Power Filter
Authors: Kaiwart Jyotsana
Published: January 2023

This paper focuses on the harmonic reduction by using shunt active power filter. The reduction in harmonics reflects as improvement in power quality. This paper includes the operation of shunt active power filter. It also includes the Simulink model and their results. It also describes the PI controller used in Simulink model. The total harmonic distortion is compared with filter and without filter. The permissible limit of THD is also followed as per IEEE.
EFFECTS OF GROUP WORK WITH CREATIVE WRITING TECHNIQUE ON STUDENTS’ NARRATIVE WRITING AT DAYANU IKHSANUDDIN UNIVERSITY BAUBAU
Authors: Herman Ary Irjayanti
Published: January 2023

The aims of this research were to find out whether the use of Group Work with Creative Writing Technique improves the students’ writing skills and  interest of students’. Quasi-experimental design was applied in this research. The experiment of this research was third semester students of English Educational Study Program of Dayanu Ikhsanuddin Baubau, in  2014/2015 academic years. The sample of the research was  80 students which consist of two classes; in experimental 40 students and control class 40 students. There were two instruments in getting the data on this research : the test on narrative writing as well as questionaires to get the interest. The researcher used descriptive and inferential for test data analysis. Meanwhile , likert cale for interest. The findings were: (1) the application of Group Work with Creative Writing technique got the students’ writing performance improved, (2) the application of Group Work with Creative Writing technique is interesting to the students on  writing class.  On the other hand, the application of Group Work with Creative Writing technique improved the students’ writing performance on content, organization, vocabulary, language use and mechanics and they got very high interest on the application of Group Work with Creative Writing technique in teaching writing.
EFFECTIVENESS OF USING WORD MAPPING STRATEGY IN INCREASING STUDENTS’ VOCABULARY MASTERY AT SMP NEGERI 3 KAPONTORI
Authors: Edy Muhammad Zakaria , Amiruddin Esa Penilta
Published: January 2023

Lack of vacabularies effects the learners in understanding English. The aim of this study was to find out the effectiveness of using word mapping strategy in increasing students’ vocabulary mastery at SMP Negeri 3 Kapontori. This study used Pre-Experimental design. The population was students of class VIII SMP Negeri 3 Kapontori academic year 2019/2020. T-test was used for analyzing the data. Research findings showed ttest was lower than ttable (-13.248 < 2.079). In conclusion, word mapping strategy effect positively on students’vocabulary mastery at SMP Negeri 3 Kapontori.
STUDENTS’ OPINIONS TOWARD WRITING ACTIVITIES
Authors: Maneba Sanaria
Published: January 2023

Problem in this research is how is students’ opinions toward writing activities. This research is a qualitative research. The subject of the research is First semester consisted of 21 students who pragrammed Basic Writing subject in English Study Program at Dayanu Ikhsanuddin University, academic year 2019-2020. The instrument used in this research is questionairre about students’ opinion toward writing activities. The test consisted of 10 numbers with 5 optional degree of feeling, are: Strongly Agree (5), Agree (4), Neither Agree nor Disagree (3), Disagree (2) and Strongly Disagree (1). Data analysis uses the percentage formula as the frequency is divided by the number of the students, then the total number of the percentage is multiplied by 100% (Sugiyono,2010 in Husain, 2012).1 The research outcomes is majority students at the first semester of English Study Program, Teaching Training and Education Faculty, Dayanu Ikhsanuddin University, academic year 2019/2020 presented their positive opinion and responses toward writing activities.
USE OF LANGUAGE LEARNING STRATEGIES TOWARDS STUDENTS’ ENGLISH ACADEMIC ACHIEVEMENT AT SMA NEGERI 1 BAUBAU
Authors: Amiruddin Esa Penilta , Maneba Sanaria
Published: January 2023

The aim of this study was to what extent language learning strategies used by students give an impact on their English academic achievement. The instrument of the research was achievement test and interview. The intention of the researchers to take the achievement test was to find out English academic achievement of learners (English grade) in second semester academic year 2019/2020. The second instrument for gathering data concerning students’ strategies was semi-structured interview. In conclusion, 45 % of the variance in the English academic achievement of IPA 1 students can be explained by the language learning strategies used, while 57 % the variance of the English academic achievement of IPA 2 students can described by the LLS employed.
STUDENTS’ SELF CONFIDENCE IN SPEAKING ENGLISH
Authors: Nety Nety , Wahyuni B Asti , Nurhaeni Nurhaeni
Published: January 2023

This research intended to analyze factors of students’ lack of self confidence in speaking English. It was also aimed to present possible strategies used to overcome students’ lack of self confidence in speaking English. The type of this research was qualitative. This research was conducted in SMA Negeri 4 BauBau. This research focused on obtaining data from the English teacher and students at eleventh grade of SMA Negeri 4 BauBau in the academic year 2018/2019 as the subjects of the research. In collecting data, the researchers used observation, interview. The technique used in analyzing data were three steps, those were data reduction, data display, and conclusion drawing. The result of this research showed that the factors which cause students’ lack of self confidence were anxiety, shyness, fear of making mistakes, and lack of vocabulary. Meanwhile, the possible strtaegies to overcome students’ lack of self confidence in speaking English were lowering students’ anxiety in classroom, improving students’ vocabulary, boosting students’ self-confidence, and forming group discussion.
CORRELATION OF SELF EFFICACY TO THE STUDENTS’ SPEAKING PERFORMANCE IN EFL CONTEXT AT UNIVERSITY OF DAYANU IKHSANUDDIN BAUBAU
Authors: Suharja Suharja
Published: January 2023

The main purpose of this study was to find out the correlation of students’ self-efficacy and their speaking performance. A self-efficacy questionnaire and a measure of speaking performance tests were administered to 95 learners of Dayanu Ikhsanuddin University. The data analysis revealed that there is a significant correlation between the students’ speaking self efficacy and their speaking performance. The probability value of speaking self efficacy is 0.001. Because p < 0.05 then Ho was rejected and Ha was accepted. It can be concluded that students’ speaking self-efficacy and speaking performance denoted a positive correlation.