bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Role of Local Many-Body Interactions on the Thermoelectric Properties of Fullerene Junctions
Authors: Perroni Carmine Antonio , Cataudella Vittorio
Published: August 2019

The role of local electron–vibration and electron–electron interactions on the thermoelectric properties of molecular junctions is theoretically analyzed focusing on devices based on fullerene molecules. A self-consistent adiabatic approach is used in order to obtain a non-perturbative treatment of the electron coupling to low frequency vibrational modes, such as those of the molecule center of mass between metallic leads. The approach also incorporates the effects of strong electron–electron interactions between molecular degrees of freedom within the Coulomb blockade regime. The analysis is based on a one-level model which takes into account the relevant transport level of fullerene and its alignment to the chemical potential of the leads. We demonstrate that only the combined effect of local electron–vibration and electron–electron interactions is able to predict the correct behavior of both the charge conductance and the Seebeck coefficient in very good agreement with available experimental data.
Comparative Thermogravimetric Assessment on the Combustion of Coal, Microalgae Biomass and Their Blend
Authors: Coimbra Ricardo N. , Escapa Carla , Otero Marta
Published: August 2019

In this work, thermogravimetric analysis (TGA), differential thermogravimetry (DTG), and differential scanning calorimetric (DSC) were used to assess the combustion of microalgae biomass, a bituminous coal, and their blend. Furthermore, different correlations were tested for estimating the high heating value of microalgae biomass and coal, with both materials possessing similar values. TGA evidenced differences between the combustion of the studied fuels, but no relevant interaction occurred during their co-combustion, as shown by the DTG and DSC curves. These curves also indicated that the combustion of the blend mostly resembled that of coal in terms of weight loss and heat release. Moreover, non-isothermal kinetic analysis revealed that the apparent activation energies corresponding to the combustion of the blend and coal were quite close. Overall, the obtained results indicated that co-combustion with coal might be a feasible waste to energy management option for the valorization of microalgae biomass resulting from wastewater treatment.
Finding Solutions for Optimal Reactive Power Dispatch Problem by a Novel Improved Antlion Optimization Algorithm
Authors: Li Zelan , Cao Yijia , Dai Le Van , Yang Xiaoliang , Nguyen Thang Trung
Published: August 2019

In this paper, a novel improved Antlion optimization algorithm (IALO) has been proposed for solving three different IEEE power systems of optimal reactive power dispatch (ORPD) problem. Such three power systems with a set of constraints in transmission power networks such as voltage limitation of all buses, limitations of tap of all transformers, maximum power transmission limitation of all conductors and limitations of all capacitor banks have given a big challenge for global optimal solution search ability of the proposed method. The proposed IALO method has been developed by modifying new solution generation technique of standard antlion optimization algorithm (ALO). By optimizing three single objective functions of systems with 30, 57 and 118 buses, the proposed method has been demonstrated to be more effective than ALO in terms of the most optimal solution search ability, solution search speed and search stabilization. In addition, the proposed method has also been compared to other existing methods and it has obtained better results than approximately all compared ones. Consequently, the proposed IALO method is deserving of a potential optimization tool for solving ORPD problem and other optimization problems in power system optimization fields.
Leakage Control and Energy Consumption Optimization in the Water Distribution Network Based on Joint Scheduling of Pumps and Valves
Authors: Shao Yu , Yu Yanxi , Yu Tingchao , Chu Shipeng , Liu Xiaowei
Published: August 2019

Apart from water quality, leakage control and energy consumption management are the most concerning challenges for water treatment plants (WTPs). The joint scheduling of pumps and pressure reducing valves (PRVs) in the water distribution network can reduce excessive pressure and distribute pressure more evenly, which achieves comprehensive reduction of leakages and energy consumption. Taking into account the main shortcomings of the commonly used methods, such as scheduling pumps or PRVs separately, or optimizing PRV settings when their position is given, etc., this paper has taken the PRV (position and setting) and the working status of variable speed pumps (VSPs) as decision variables and the cost savings contributed by leakage reduction and energy consumption savings as the objective function, which maximized the economic benefits brought by PRV and/or VSP scheduling. A genetic algorithm (GA) was used to optimize the solution under multiple working conditions. The performance of three control strategies (PRV-only scheduling, VSP-only scheduling, and joint scheduling of PRVs and VSPs) are compared to each other based on a small network. Joint scheduling has achieved the best economic benefits in reducing the gross cost (contributed by leakage and energy consumption) of the three control strategies, which results in a leakage reduction of 33.4%, an energy consumption reduction of 25.4%, and a total cost reduction of 33.1%, when compared to the original network, and saving about 1148 m 3 water (7% of the original consumption) and 722 kWh electric energy (25.4% of the original consumption) per day.
Flow Regime Analysis of the Pressure Build-Up during CO2 Injection in Saturated Porous Rock Formations
Authors: Sarris Ernestos , Gravanis Elias
Published: August 2019

In this work, we are concerned with the theoretical and numerical analysis of the pressure build-up on the cap of an aquifer during CO2 injection in saturated porous rock formations in all flow regimes of the problem. The latter are specific regions of the parameter space of the plume flow, defined by the CO2-to-brine relative mobility and the buoyancy parameter (injection pressure to buoyancy pressure scale ratio). In addition to the known asymptotic self-similar solutions for low buoyancy, we introduce two novel ones for the high buoyancy regimes via power series solutions of asymptotic self-similarity equations. The explicit results for the peak value of pressure on the cap, which arises in the vicinity of the well, are derived and discussed for all flow regimes. The analytical results derived in this work are applied for the purpose of cap integrity considerations in six test cases of CO2 geological storage from the PCOR partnership, most of which correspond to high buoyancy conditions. The validity of the self-similar solutions (late time asymptotics) is verified with CFD numerical simulations performed with the software Ansys-Fluent. The result is that the self-similar solutions and the associated pressure estimations are valid in typical injection durations of interest, even for early times.
The Advanced Control Approach based on SMC Design for the High-Fidelity Haptic Power Lever of a Small Hybrid Electric Aircraft
Authors: Hace Aleš
Published: August 2019

In the serial hybrid electric propulsion system of a small propeller aircraft the battery state of charge is fluctuating due to the diversity of possible power flows. Overwhelming visual information on the cockpit displays, besides requiring visual pilot attention, increases pilot workload, which is undesirable, especially in risky flight situations. Haptic interfaces, on the other hand, can provide intuitive cues that can be applied to enhance and simplify the cockpit. In this paper, we deal with an enhanced power lever stick, which can provide feedback force feel with haptic cues for enhanced information flow between the pilot and the powertrain system. We present selected haptic patterns for specific information related to the fluctuating battery state of charge. The haptic patterns were designed to reduce pilot workload, and for easy use, safe and energy-efficient control of the hybrid electric powertrain system. We focus on the advanced control design for high-performance force feedback required for rendering fine haptic signals, which stimulates the sensitive haptics of a pilot’s hand-arm system. The presented control algorithm has been designed by the sliding mode control (SMC) approach in order to provide disturbance rejection and high-fidelity haptic rendering. The proposed control design has been validated on an experimental prototype system.
DBSCAN-Based Thermal Runaway Diagnosis of Battery Systems for Electric Vehicles
Authors: Li Da , Zhang Zhaosheng , Liu Peng , Wang Zhenpo
Published: August 2019

Battery system diagnosis and prognosis are essential for ensuring the safe operation of electric vehicles (EVs). This paper proposes a diagnosis method of thermal runaway for ternary lithium-ion battery systems based on the Density-Based Spatial Clustering of Applications with Noise (DBSCAN) clustering. Two-dimensional fault characteristics are first extracted according to battery voltage, and DBSCAN clustering is used to diagnose the potential thermal runaway cells (PTRC). The periodic risk assessing strategy is put forward to evaluate the fault risk of battery cells. The feasibility, reliability, stability, necessity, and robustness of the proposed algorithm are analyzed, and its effectiveness is verified based on datasets collected from real-world operating electric vehicles. The results show that the proposed method can accurately predict the locations of PTRC in the battery pack a few days before the thermal runaway occurrence.
Estimation of Forest Biomass and Carbon Storage in China Based on Forest Resources Inventory Data
Authors: Lu Jing , Feng Zhongke , Zhu Yan
Published: August 2019

Forests are important in the global carbon cycle and it is necessary to quickly and accurately measure forest volume to estimate forest aboveground biomass (AGB) and aboveground carbon storage (AGC). In this paper, we used data from the eighth forest resources inventory of China to establish two stand volume models based on stand density and forest basal area for 37 arbor forest types (dominant species); and performed a comparative analysis to obtain the best model. Then the AGB, AGB density, AGC, and AGC density of the different forest types and regions were estimated by conversion function methods. The results showed that: (1) The volume model of tree height and forest basal area could better fit the natural growth process of forests, and 36 of the 37 forest types had R2 greater than 0.8; (2) The average AGB density of arbor forest in China was 95.03 Mg ha−1 and the average AGC density was 48.15 Mg ha−1 (3) Among forest types, Picea asperata Mast., Quercus spp., and Populus spp. had the highest AGB and AGC, while Cinnamomum camphora (L.) Presl, Pinus taiwanensis Hayata, and Pinus densiflora Sieb. et Zucc. had the lowest. The AGB density and AGC density of Phoebe zhennan S. Lee et F. N. Wei and Pinus densata Mast. were the highest, while those of Pinus densiflora Sieb. et Zucc., Pinus elliottii Engelmann, and Eucalyptus robusta Smith were the lowest. (4) Among regions, AGB and AGC ranging from high to low, were as follows: northwest, southwest, northeast, central south, east, and north. The northwest and southwest regions accounted for more than 70% of the country’s AGB and AGC. The average AGB density and AGC density among the regions were 91.34 Mg ha−1 and 46.4 Mg ha−1, respectively. Ranging from high to low as follows: southwest, northwest, northeast, east, central south, and north. The methods used in this paper provide a basis for fast and accurate estimation of stand volume, and the estimates of AGB and AGC have important reference value for explaining the role of ecosystems in coping with global climate change in China.
Scientific Challenges in Performing Life-Cycle Assessment in the Food Supply Chain
Authors: Djekic Ilija , Pojić Milica , Tonda Alberto , Putnik Predrag , Bursać Kovačević Danijela , Režek-Jambrak Anet , Tomasevic Igor
Published: August 2019

This paper gives an overview of scientific challenges that occur when performing life-cycle assessment (LCA) in the food supply chain. In order to evaluate these risks, the Failure Mode and Effect Analysis tool has been used. Challenges related to setting the goal and scope of LCA revealed four hot spots: system boundaries of LCA; used functional units; type and quality of data categories, and main assumptions and limitations of the study. Within the inventory analysis, challenging issues are associated with allocation of material and energy flows and waste streams released to the environment. Impact assessment brings uncertainties in choosing appropriate environmental impacts. Finally, in order to interpret results, a scientifically sound sensitivity analysis should be performed to check how stable calculations and results are. Identified challenges pave the way for improving LCA of food supply chains in order to enable comparison of results.
The Use of Upcycled Defatted Sunflower Seed Flour as a Functional Ingredient in Biscuits
Authors: Grasso Simona , Omoarukhe Ese , Wen Xiaokang , Papoutsis Konstantinos , Methven Lisa
Published: August 2019

Defatted sunflower seed flour (DSSF) is an upcycled by-product of sunflower oil extraction, rich in protein, fibre and antioxidants. This study assessed the instrumental and sensory quality of biscuits enriched with DSSF at 18% and 36% w/w as a replacement for wheat flour. Measurements included colour, texture, total phenolic content (TPC) and antioxidant capacity. Sensory analysis was carried out with Quantitative Descriptive Analysis (QDA). The inclusion of DSSF significantly increased the protein content of the biscuits, as well as the TPC and antioxidant capacity of the biscuits. The resulting products were significantly darker, less red and less yellow with increasing DSSF levels, while hardness (measured instrumentally) increased. Sensory results agreed with colour measurements, concluding that DSSF biscuits were more “Brown” than the control, and with texture measurements where biscuits with 36% DSSF had a significantly firmer bite. In addition, DSSF biscuits at 36% inclusion had higher QDA scores for “Off-note” and the lowest scores for “Crumbly” and “Crumb aeration”. DSSF biscuits at 18% inclusion were similar to the control in most parameters and should be considered for further developments. These results show the potential of the upcycled DSSF by-product as a novel, sustainable and healthy food ingredient.
Biogenic Amines, Phenolic, and Aroma-Related Compounds of Unroasted and Roasted Cocoa Beans with Different Origin
Authors: Spizzirri Umile Gianfranco , Ieri Francesca , Campo Margherita , Paolino Donatella , Restuccia Donatella , Romani Annalisa
Published: August 2019

Biogenic amines (BAs), polyphenols, and aroma compounds were determined by chromatographic techniques in cocoa beans of different geographical origin, also considering the effect of roasting (95, 110, and 125 °C). In all samples, methylxantines (2.22–12.3 mg kg−1) were the most abundant followed by procyanidins (0.69–9.39 mg kg−1) and epicatechin (0.16–3.12 mg kg−1), all reduced by heat treatments. Volatile organic compounds and BAs showed variable levels and distributions. Although showing the highest BAs total content (28.8 mg kg−1), Criollo variety presented a good aroma profile, suggesting a possible processing without roasting. Heat treatments influenced the aroma compounds especially for Nicaragua sample, increasing more than two-fold desirable aldehydes and pyrazines formed during the Maillard cascade and the Strecker degradation. As the temperature increased, the concentration of BAs already present in raw samples increased as well, although never reaching hazardous levels.
From Byproduct to Resource: Fermented Apple Pomace as Beer Flavoring
Authors: Ricci Annalisa , Cirlini Martina , Guido Angela , Liberatore Claudia , Ganino Tommaso , Lazzi Camilla , Chiancone Benedetta
Published: August 2019

One of the main struggles of the large-scale apple processing industry is pomace disposal. One solution for this problem is to convert this waste into a resource. Apple pomace could be used as a substrate for lactic acid bacteria and could induce the formation of a more complex aroma profile, making this fermented product an innovative aromatizer for alcoholic beverages, such as beer. In this study, for the first time, the effect of lacto-fermented apple pomace addition in beer was evaluated. Three bacterial strains (Lactobacillus rhamnosus 1473 and 1019, and L. casei 2246) were tested for apple pomace fermentation, and L. rhamnosus 1473 was the strain that best modified the aromatic profile. The addition of fermented apple pomace to beer increased the complexity of the aroma profile, demonstrating the potential of this byproduct as an aromatizer in the alcoholic beverage industry.
Classification of Hen Eggs by HPLC-UV Fingerprinting and Chemometric Methods
Authors: Campmajó Guillem , Cayero Laura , Saurina Javier , Núñez Oscar
Published: August 2019

Hen eggs are classified into four groups according to their production method: Organic, free-range, barn, or caged. It is known that a fraudulent practice is the misrepresentation of a high-quality egg with a lower one. In this work, high-performance liquid chromatography with ultraviolet detection (HPLC-UV) fingerprints were proposed as a source of potential chemical descriptors to achieve the classification of hen eggs according to their labelled type. A reversed-phase separation was optimized to obtain discriminant enough chromatographic fingerprints, which were subsequently processed by means of principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA). Particular trends were observed for organic and caged hen eggs by PCA and, as expected, these groupings were improved by PLS-DA. The applicability of the method to distinguish egg manufacturer and size was also studied by PLS-DA, observing variations in the HPLC-UV fingerprints in both cases. Moreover, the classification of higher class eggs, in front of any other with one lower, and hence cheaper, was studied by building paired PLS-DA models, reaching a classification rate of at least 82.6% (100% for organic vs. non-organic hen eggs) and demonstrating the suitability of the proposed method.
Solving Helmholtz Equation with Local Fractional Derivative Operators
Authors: Baleanu Dumitru , Jassim Hassan Kamil , Al Qurashi Maysaa
Published: August 2019

The paper presents a new analytical method called the local fractional Laplace variational iteration method (LFLVIM), which is a combination of the local fractional Laplace transform (LFLT) and the local fractional variational iteration method (LFVIM), for solving the two-dimensional Helmholtz and coupled Helmholtz equations with local fractional derivative operators (LFDOs). The operators are taken in the local fractional sense. Two test problems are presented to demonstrate the efficiency and the accuracy of the proposed method. The approximate solutions obtained are compared with the results obtained by the local fractional Laplace decomposition method (LFLDM). The results reveal that the LFLVIM is very effective and convenient to solve linear and nonlinear PDEs.
The Idea of Using Bayesian Networks in Forecasting Impact of Traffic-Induced Vibrations Transmitted through the Ground on Residential Buildings
Authors: Siemaszko Agata , Jakubczyk-Gałczyńska Anna , Jankowski Robert
Published: August 2019

Traffic–induced vibrations may constitute a considerable load to buildings. In this paper, vibrations transmitted through the ground caused by wheeled vehicles are considered. This phenomenon may cause cracking of plaster, cracks in load-bearing elements or even, in extreme cases, collapse of the whole structure. Measurements of vibrations of real structures are costly and laborious. Therefore, the aim of the present paper is to propose a method of using Bayesian networks combined with implementation of geoscience for assessment of impact of traffic–induced vibrations on residential buildings. Firstly, the experimental tests were performed on different buildings using specialized equipment taking into account five factors: Distance from the building to the edge of the road, condition of road surface, condition of the building, the absorption of soil and the type of vehicle. Then, probabilistic analyses applying Bayesian networks were conducted and two methods of assessing the information value (EVSI method and entropy method) were compared. Finally, the developed diagnostic–decision support model was tested, so as to verify the most important parameter, affecting the possibility of structural vibrations to occur. The results of the study clearly showed that the use of Bayesian networks was a very effective approach to assess the impact of traffic-induced vibrations. The developed algorithm could be successfully applied both to existing and planned buildings, for which the source of vibration is already present or may appear in the future.
Factors Influencing Hospitalization Rates and Inpatient Cost of Patients with Tuberculosis in Jiangsu Province, China: An Uncontrolled before and after Study
Authors: Hu Dan , Long Qian , Chen Jiaying , Wang Xuanxuan , Huang Fei , Ji John S.
Published: August 2019

Objective: The China Center for Disease Control and Prevention (CDC) introduced an innovative financing model of tuberculosis (TB) care and control with the aim of standardizing TB treatment and reducing the financial burden associated with patients with TB. This is a study of the pilot implementation of new financing mechanism in Zhenjiang, between 2014–2015. We compared TB hospitalization rates and inpatient service costs before and after implementation to examine the factors associated with hospital admissions. Our goal is to provide evidence-based recommendations for improving TB service provision and cost control. Methods: We reviewed new policy documents on TB financing. We conducted a patient survey to investigate the utilization of inpatient services, and patients’ out-of-pocket payment for inpatient care. We extracted total medical expenditures of inpatient services from inpatient records of TB designated hospitals. Findings: 63.6% (n = 159) of the surveyed patients with TB were admitted for treatment in 2015, which was higher than that in 2013 (54.8%, n = 144). The number of hospital admission was slightly lower in 2015 (1.16 per patient) than in 2013 (1.26 per patient), while the length of hospital stay was longer in 2015 (24 days) than in 2013 (16 days). In 2015, patients from families with low incomes were more likely to be admitted than those from higher income groups (OR = 3.06, 95% CI: 1.12–8.33). The average inpatient service cost in 2015 (3345 USD) was 1.7 times the cost in 2013 (1952 USD). It was found that 96.2% of patients with TB who were from low-income households spent more than 20% of their household income on inpatient care in 2013, versus 100% in 2015. Conclusion: The TB hospital admission rate and total inpatient service cost increased over the study period. The majority of patients with TB, particularly poor patient who used inpatient care, continue to suffer from heavy financial burden.
Cardiac Cx43 and ECM Responses to Altered Thyroid Status Are Blunted in Spontaneously Hypertensive versus Normotensive Rats
Authors: Sykora Matus , Szeiffova Bacova Barbara , Egan Benova Tamara , Barancik Miroslav , Zurmanova Jitka , Rauchova Hana , Weismann Peter , Pavelka Stanislav , Kurahara Lin Hai , Slezak Jan , Soukup Tomas , Tribulova Narcis
Published: August 2019

Heart function and its susceptibility to arrhythmias are modulated by thyroid hormones (THs) but the responsiveness of hypertensive individuals to thyroid dysfunction is elusive. We aimed to explore the effect of altered thyroid status on crucial factors affecting synchronized heart function, i.e., connexin-43 (Cx43) and extracellular matrix proteins (ECM), in spontaneously hypertensive rats (SHRs) compared to normotensive Wistar Kyoto rats (WKRs). Basal levels of circulating THs were similar in both strains. Hyperthyroid state (HT) was induced by injection of T3 (0.15 mg/kg b.w. for eight weeks) and hypothyroid state (HY) by the administration of methimazol (0.05% for eight weeks). The possible benefit of omega-3 polyunsaturated fatty acids (Omacor, 200 mg/kg for eight weeks) intake was examined as well. Reduced levels of Cx43 in SHRs were unaffected by alterations in THs, unlike WKRs, in which levels of Cx43 and its phosphorylated form at serine368 were decreased in the HT state and increased in the HY state. This specific Cx43 phosphorylation, attributed to enhanced protein kinase C-epsilon signaling, was also increased in HY SHRs. Altered thyroid status did not show significant differences in markers of ECM or collagen deposition in SHRs. WKRs exhibited a decrease in levels of profibrotic transforming growth factor β1 and SMAD2/3 in HT and an increase in HY, along with enhanced interstitial collagen. Short-term intake of omega-3 polyunsaturated fatty acids did not affect any targeted proteins significantly. Key findings suggest that myocardial Cx43 and ECM responses to altered thyroid status are blunted in SHRs compared to WKRs. However, enhanced phosphorylation of Cx43 at serine368 in hypothyroid SHRs might be associated with preservation of intercellular coupling and alleviation of the propensity of the heart to malignant arrhythmias.
Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice
Authors: Mensching Leonore , Djogo Nevena , Keller Christina , Rading Sebastian , Karsak Meliha
Published: August 2019

The G-protein coupled cannabinoid receptor 2 (CB2) has been implicated in the regulation of adult neurogenesis in the hippocampus. The contribution of CB2 towards basal levels of proliferation and the number of neural progenitors in the subgranular zone (SGZ) of the dentate gyrus, however, remain unclear. We stained hippocampal brain sections of 16- to 17-week-old wildtype and CB2-deficient mice, for neural progenitor and immature neuron markers doublecortin (DCX) and calretinin (CR) and for the proliferation marker Ki67 and quantified the number of positive cells in the SGZ. The quantification revealed that CB2 deficiency neither altered overall cell proliferation nor the size of the DCX+ or DCX and CR double-positive populations in the SGZ compared to control animals. The results indicate that CB2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice. CB2 signaling might be more relevant in conditions where adult neurogenesis is dynamically regulated, such as neuroinflammation.
Incomplete Spinal Cord Injury Reverses the Level-Dependence of Spinal Cord Injury Immune Deficiency Syndrome
Authors: Hong James , Chang Alex , Liu Yang , Wang Jian , Fehlings Michael G.
Published: August 2019

Spinal cord injury (SCI) is associated with an increased susceptibility to infections, such as pneumonia, which is the leading cause of death in these patients. This phenomenon is referred to as SCI immune deficiency syndrome (SCI-IDS), and has been shown to be more prevalent after high-level transection in preclinical SCI models. Despite the high prevalence of contusion SCIs, the effects of this etiology have not been studied in the context of SCI-IDS. Compared to transection SCIs, which involve a complete loss of supraspinal input and lead to the disinhibition of spinally-generated activity, contusion SCIs may cause significant local deafferentation, but only a partial disruption of sympathetic tone below the level of injury. In this work, we investigate the effects of thoracic (T6-7) and cervical (C6-7) moderate–severe contusion SCIs on the spleen by characterizing splenic norepinephrine (NE) and cortisol (CORT), caspase-3, and multiple inflammation markers at 3- and 7-days post-SCI. In contrary to the literature, we observe an increase in splenic NE and CORT that correspond to an increase in caspase-3 after thoracic SCI relative to cervical SCI. Further, we found differences in expression of leptin, eotaxin, IP-10, and IL-18 that implicate alterations in splenocyte recruitment and function. These results suggest that incomplete SCI drastically alters the level-dependence of SCI-IDS.
A Re-Evaluation of Olive Fruit Fly Organophosphate-Resistant Ace Alleles in Iberia, and Field-Testing Population Effects after in-Practice Dimethoate Use
Authors: Nobre Tânia , Gomes Luis , Rei Fernando
Published: August 2019

The management of the olive fruit fly (Bactrocera oleae) is traditionally based upon the use of organophosphate insecticides, mainly dimethoate. In this evolutionary arms race between man and pest, the flies have adapted a pesticide resistance, implying two point-mutations of the Ace gene -I214V and G488S- and a 9bp deletion -Δ3Q. We revisited 11 Iberian locations to evaluate this adaptation of organophosphate (OP)-resistant alleles through amplicon sequencing. Screening for populations where the wild type is prevalent allows an identification of hotspots for targeted mitigation measures; we have hence refined the scale to the region with the lowest OP-resistant alleles frequency 71 locations were sampled and individuals checked using a fast and low-cost allele-specific-primer polymerase chain reaction (ASP-PCR) method]. An increase in Ace gene point-mutations was observed, and the Δ3Q mutation remains undetected. The lowest frequencies of the OP-resistant alleles remain in the west, underlining the hypothesis of an introduction of resistance from eastern Mediterranean areas. A field test was performed by sampling the fly population before and after in-practice dimethoate application. A clear reduction in olive fruit fly numbers was observed, with no relevant changes in the genotypic frequencies of the resistance alleles. The findings are discussed in frame of the type and intensity of the selection pressure that has led to the adaptation to resistance and its consequences from the producer perspective.
Standardized Ixodid Tick Survey in Mainland Florida
Authors: Glass Gregory E. , Ganser Claudia , Wisely Samantha M. , Kessler William H.
Published: August 2019

A statewide survey of questing ixodid ticks in mainland Florida was developed consistent with U.S. CDC standards to maximize the amount of epidemiologic and environmental data gathered. Survey sites were stratified by climatic zones and proportional to recognized land cover categories. A total of 560 transects on 41 sites within the state were sampled repeatedly by flagging between 2015 and 2018. Four tick species were collected; Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis and Dermacentor variabilis. All species were more commonly found in northern and central regions of the state than in southern and western regions. Adult I. scapularis were active from autumn through spring and complementary to adult A. americanum and D. variabilis. Standardized survey methods help reduce sampling biases and better characterize risk from the species surveyed. However, differences in the attractiveness of collection methods for different tick species makes cross-species comparisons a continuing challenge.
The Role of Exosomes in Bronchoalveloar Lavage from Patients with Acute Respiratory Distress Syndrome
Authors: Kim Tae Hoon , Hong Sang-Bum , Lim Chae-Mann , Koh Younsuck , Jang Eun-young , Huh Jin Won
Published: August 2019

Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition caused by pulmonary and extrapulmonary insults. Exosomes are considered a major cell-to-cell communicator and immune modulator. However, their role in ARDS remains unclear. In this study, we investigated whether exosomes could be a potential biomarker of ARDS. Methods: We isolated exosomes from bronchoalveolar lavage (BAL) of patients with ARDS. The correlation between the level of exosomes with clinical data, including etiology, oxygenation, and 28-day mortality was analyzed. Enzyme-linked immune sorbent assays and western blotting were carried out to characterize BAL exosomes. Immune modulating response of exosomes was investigated by in vitro examination. Results: From 158 patients, we isolated mean 1568.9 µg/mL BAL exosomes, which presented a negative correlation with the PaO2/FiO2 ratio. The level of exosomes did not correlate with 28-day mortality but was elevated in the infectious etiology of ARDS. The exosomes have cargo proteins associated with apoptosis, necroptosis, and autophagy. An in vitro stimulation study revealed that BAL exosomes could induce the production of proinflammatory cytokines and chemokines, but those from patients with ARDS suppressed the production of vascular endothelial growth factor. Conclusions: In ARDS, exosomes are released in alveolar space, and the level is correlated with the etiology of ARDS. BAL exosomes could play an immune-modulating role by controlling the production of cytokines.
Sandwich Panels Bond with Advanced Adhesive Films
Authors: Pereira António Bastos , Fernandes Fábio A.O.
Published: August 2019

Sandwich structures present several advantages, being used in many industries such as the aeronautical industry. In this study, an automated laminating line is employed to manufacture sandwich panels for boards. This work focus on an innovative solution, employing an advanced adhesive film to increase the bonding strength of sandwich structures used for this application. This was used to bond ceramic steel sheets to honeycomb-cored structures, creating an innovative solution for the board industry. Bending tests were carried to evaluate the performance of the new sandwich solutions and to compare it against a typical one available on the market.
Biocompatibility of Nanocellulose-Reinforced PVA Hydrogel with Human Corneal Epithelial Cells for Ophthalmic Applications
Authors: Tummala Gopi Krishna , Lopes Viviana R. , Mihranyan Albert , Ferraz Natalia
Published: August 2019

Transparent composite hydrogel in the form of a contact lens made from poly(vinyl alcohol) (PVA) and cellulose nanocrystals (CNCs) was subjected to in vitro biocompatibility evaluation with human corneal epithelial cells (HCE-2 cells). The cell response to direct contact with the hydrogels was investigated by placing the samples on top of confluent cell layers and evaluating cell viability, morphology, and cell layer integrity subsequent to 24 h culture and removal of the hydrogels. To further characterize the lens–cell interactions, HCE-2 cells were seeded on the hydrogels, with and without simulated tear fluid (STF) pre-conditioning, and cell viability and morphology were evaluated. Furthermore, protein adsorption on the hydrogel surface was investigated by incubating the materials with STF, followed by protein elution and quantification. The hydrogel material was found to have affinity towards protein adsorption, most probably due to the interactions between the positively charged lysozyme and the negatively charged CNCs embedded in the PVA matrix. The direct contact experiment demonstrated that the physical presence of the lenses did not affect corneal epithelial cell monolayers in terms of integrity nor cell metabolic activity. Moreover, it was found that viable corneal cells adhered to the hydrogel, showing the typical morphology of epithelial cells and that such response was not influenced by the STF pre-conditioning of the hydrogel surface. The results of the study confirm that PVA-CNC hydrogel is a promising ophthalmic biomaterial, motivating future in vitro and in vivo biocompatibility studies.
Snowglow—The Amplification of Skyglow by Snow and Clouds Can Exceed Full Moon Illuminance in Suburban Areas
Authors: Jechow Andreas , Hölker Franz
Published: August 2019

Artificial skyglow, the fraction of artificial light at night that is emitted upwards from Earth and subsequently scattered back within the atmosphere, depends on atmospheric conditions but also on the ground albedo. One effect that has not gained much attention so far is the amplification of skyglow by snow, particularly in combination with clouds. Snow, however, has a very high albedo and can become important when the direct upward emission is reduced when using shielded luminaires. In this work, first results of skyglow amplification by fresh snow and clouds measured with all-sky photometry in a suburban area are presented. Amplification factors for the zenith luminance of 188 for snow and clouds in combination and 33 for snow alone were found at this site. The maximum zenith luminance of nearly 250 mcd/m2 measured with snow and clouds is a factor of 1000 higher than the commonly used clear sky reference of 0.25 mcd/m2. Compared with our darkest zenith luminance of 0.07 mcd/m2 measured for overcast conditions in a very remote area, this leads to an overall amplification factor of ca. 3500. Horizontal illuminance measurements show values of up to 0.79 lx, exceeding maximum possible full-moon illuminance levels by more than a factor of two. Additional measurements near the Arctic Circle for clear and overcast conditions are presented and strategies for further studies are discussed. We propose the term “snowglow” to describe the amplification of skyglow by snow with and without clouds.
An Integrated Approach for the Assessment of Central Cooling Retrofit Using Variable Speed Drive Pump in Marine Applications
Authors: Pariotis Efthimios G. , Zannis Theodoros C. , Katsanis John S.
Published: August 2019

The present study describes a model-based approach for the assessment of central cooling retrofit solutions using variable speed drive (VSD) seawater (SW) pumps in marine applications. There are two main innovative features of the proposed methodology. The effect of boundary conditions (fluid stream temperatures and mass flow rates) on the performance of central SW/fresh water (FW) cooler is considered via a detailed heat exchanger simulation model. Additionally, the repercussion of the higher FW temperature on the main engine fuel consumption due to the incorporation of a VSD SW pump is examined. The proposed methodology is applied on a handy-size bulk carrier equipped with a shell and tube SW/FW central cooler and a two-stroke main diesel engine. Both the reduced power demand for the VSD pump and the increased brake specific fuel consumption (bsfc) of the main engine due to the increased low temperature (LT)/FW temperature have been considered at each operating point examined. Predictions have shown that in all part-load operating cases examined the use of a VSD SW pump has a positive effect on the reduction of total fuel consumption, whereas at full engine load, there is a SW threshold temperature under which the operation with a VSD pump leads to slightly higher total fuel consumption. This study highlights the importance of using an integrated approach for the reliable assessment of central cooling retrofit solutions, which can lead to optimized control solutions of the VSD pump operation for maximizing a ship’s fuel savings.
The Growth of Photoactive Porphyrin-Based MOF Thin Films Using the Liquid-Phase Epitaxy Approach and Their Optoelectronic Properties
Authors: Ngongang Ndjawa Guy Olivier , Tchalala Mohamed R. , Shekhah Osama , Khan Jafar I. , Mansour Ahmed E. , Czaban-Jóźwiak Justyna , Weselinski Lukasz J. , Ahsaine Hassan Ait , Amassian Aram , Eddaoudi Mohamed
Published: August 2019

This study reports on the optoelectronic properties of porphyrin-based metal–organic framework (MOF) thin films fabricated by a facile liquid-phase epitaxy approach. This approach affords the growth of MOF thin films that are free of morphological imperfections, more suitable for optoelectronic applications. Chemical modifications such as the porphyrin ligand metallation have been found to preserve the morphology of the grown films making this approach particularly suitable for molecular alteration of MOF thin film optoelectronic properties without compromising its mesoscale morphology significantly. Particularly, the metallation of the ligand was found to be effective to tune the MOF bandgap. These porphyrin-based MOF thin films were shown to function effectively as donor layers in solar cells based on a Fullerene-C60 acceptor. The ability to fabricate MOF solar cells free of a liquid-phase acceptor greatly simplifies device fabrication and enables pairing of MOFs as light absorbers with a wide range of acceptors including non-fullerene acceptors.
A New Family of High Tc Molecule-Based Magnetic Networks: V[x-ClnPTCE]2·yCH2Cl2 (PTCE = Phenyltricyanoethylene)
Authors: Tatum David S. , Zadrozny Joseph M. , Yee Gordon T.
Published: August 2019

Using the structural and electronic tunability of molecules to control magnetism is a central challenge of inorganic chemistry. Herein, a ten-member family of the high-ordering temperature (Tc) molecule-based magnetic coordination networks of the form V[x-ClnPTCE]2·yCH2Cl2 (PTCE = phenyltricyanoethylene, y < 0.5) were synthesized and characterized, where x is (are) the position(s) and n is the number of chlorine substitutions on the phenyl ring. These chlorophenyltricyanoethelenes are tunable analogs of the more commonly investigated tetracyanoethylene (TCNE). Varying the number and position of chlorine substitution around the phenyl ring engendered a family of network solids with significantly different magnetic ordering temperatures ranging from 146 to 285 K. The Tcs of these ferrimagnets were rationalized with the aid of cyclic voltammetry and Density Functional Theory (DFT) calculations.
On the Oscillation of Non-Linear Fractional Difference Equations with Damping
Authors: Alzabut Jehad , Muthulakshmi Velu , Özbekler Abdullah , Adıgüzel Hakan
Published: August 2019

In studying the Riccati transformation technique, some mathematical inequalities and comparison results, we establish new oscillation criteria for a non-linear fractional difference equation with damping term. Preliminary details including notations, definitions and essential lemmas on discrete fractional calculus are furnished before proceeding to the main results. The consistency of the proposed results is demonstrated by presenting some numerical examples. We end the paper with a concluding remark.
Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects
Authors: Schmitz Christian , González Auza Lilian , Koberidze David , Rasche Stefan , Fischer Rainer , Bortesi Luisa
Published: August 2019

Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chitosan oligomers (COS). These molecules have various useful properties, including antimicrobial and anti-inflammatory activities. The chemical production of COS is environmentally hazardous and it is difficult to control the degree of polymerization and acetylation. These issues can be addressed by using specific enzymes, particularly chitinases, chitosanases and chitin deacetylases, which yield better-defined chitosan and COS mixtures. In this review, we summarize recent chemical and enzymatic approaches for the production of chitosan and COS. We also discuss a design-of-experiments approach for process optimization that could help to enhance enzymatic processes in terms of product yield and product characteristics. This may allow the production of novel COS structures with unique functional properties to further expand the applications of these diverse bioactive molecules.
Whole Grain Consumption for the Prevention and Treatment of Breast Cancer
Authors: Xie Mingsi , Liu Jie , Tsao Rong , Wang Ziyuan , Sun Baoguo , Wang Jing
Published: August 2019

Breast cancer is one of the most common and malignant cancers among females worldwide. Several epidemiological studies have indicated the inverse correlation between the intake of whole grains and the incidence of breast cancer. Whole grains are the most fundamental and important food source of bioactive phytochemicals, which have well-defined roles in the management of each stage of breast carcinogenesis. To better understand the value of whole grains in future prevention and treatment of breast cancer, the effects and possible mechanisms of six different whole grain cereals, which are the most commonly consumed throughout the world, are introduced in the current review. Moreover, the bioactive compounds extracted from whole grains are adequately formulated and the underlying mechanism of action is illustrated. In addition, the present limitations and future perspective of whole grain consumption for breast cancer are also concluded. The objective of this review is to promote the development of nutraceutical and functional food from whole grains and its application for reducing the risk of breast cancer.
Nutritrauma: A Key Concept for Minimising the Harmful Effects of the Administration of Medical Nutrition Therapy
Authors: Yébenes Juan , Campins Lluis , Martínez de Lagran Itziar , Bordeje Lluisa , Lorencio Carol , Grau Teodoro , Montejo Juan , Bodí Maria , Serra-Prat Mateu ,   Working Group on Nutrition and Metabolism of the Spanish Society of Critical Care
Published: August 2019

Critically ill patients often require life support measures such as mechanical ventilation or haemodialysis. Despite the essential role of nutrition in patients’ recovery, the inappropriate use of medical nutrition therapy can have deleterious effects, as is the case with the use of respiratory, circulatory, or renal support. To increase awareness and to monitor the effects of inappropriate medical nutrition therapy, we propose to introduce the concept of nutritrauma in clinical practice, defined as metabolic adverse events related to the inappropriate administration of medical nutrition therapy or inadequate nutritional monitoring.
Vitamin D Status and Indices of Mineral Homeostasis in the Population: Differences Between 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D
Authors: Cirillo Massimo , Bilancio Giancarlo , Guarino Ermanno , Cavallo Pierpaolo , Lombardi Cinzia , Costanzo Simona , De Curtis Amalia , Di Castelnuovo Augusto , Iacoviello Licia
Published: August 2019

Opinions are conflicting about the epidemiology of vitamin D deficiency. This population-based study investigated cross-sectionally the associations of 25-hydroxyvitamin D (calcidiol) and 1,25-dihydroxyvitamin D (calcitriol) with indices of mineral homeostasis. Study cohort consisted of 979 persons of the Moli-Sani study, both sexes, ages ≥35 years. Data collection included serum calcidiol by different assays, serum calcitriol, serum parathyroid hormone, serum and urine calcium, and phosphorus. Prevalence of mild-to-moderate calcidiol deficiency (10–19 ng/mL) was 36.4% and did not associate with hypocalcemia or hyperparathyroidism. Prevalence of severe calcidiol deficiency (<10 ng/mL) was 16.8% and associated with hyperparathyroidism only (odds ratio = 8.81, 95% confidence interval = 2.4/32.9). Prevalence of calcitriol deficiency (<18 pg/mL) was 3.1% and associated with hypocalcemia (29.1, 7.4/114.5) but not hyperparathyroidism. In ANOVA along concentration strata, lower calcidiol associated with higher parathyroid hormone only (p < 0.001). Lower calcitriol associated with lower serum and urine calcium (p < 0.001) but not with parathyroid hormone. Calcidiol findings were consistent with different calcidiol assays. In the population, mild-to-moderate calcidiol deficiency did not associate with abnormal mineral homeostasis. Severe calcidiol deficiency and calcitriol deficiency associated with different disorders: lower calcidiol associated with hyperparathyroidism whereas lower calcitriol associated with hypocalcemia and low urine calcium.