bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review and Meta-Analysis of Tau Protein and Other Major Biomarkers that Predict Unfavorable Outcomes in Severe Traumatic Brain Injury
Authors: Behzadi Faraz , Luy Diego D. , Zywiciel Joseph F. , Schaible Peter A. , Puccio Ava M. , Germanwala Anand V.
Published: January 2024

Introduction: Initial traumatic brain injury (TBI) presentation and late clinical outcomes are usually evaluated by the Glasgow Coma Scale which lacks strong prognostic predictability. Several blood biomarkers have been linked to TBI, such as Tau, GFAP, UCH-L1, S-100B, and NSE. Clinical values of TBI biomarkers have yet to be evaluated in a focused multi-study meta-analysis. We reviewed relevant articles evaluating potential relationships between TBI biomarkers and both early and 6-month outcomes.
Methods: All PubMed article publications from January 2000 to November 2023 with the search criteria: “Biomarker” AND “Traumatic Brain Injury” were included. Amongst all comparative studies, the sensitivity means and range values of biomarkers in predicting CT Rotterdam scores, early ICU admission in the early period, or predicting GOS-E < 4 at the 6-month period were calculated from confusion matrices. Sensitivity values were modeled for each biomarker across studies and compared statistically for heterogeneity and differences.
Results: From the 65 articles that met our criteria, 13 were included in this study. Six articles involved early-period TBI outcomes and seven involved 6-month outcomes. In the early period TBI outcomes, GFAP had a superior sensitivity to UCH-L1 and S-100B, and similar sensitivity to the CT Rotterdam score. In the 6-month period TBI outcomes, total Tau and NSE both had significant interstudy heterogeneity, making them inferior to GFAP, phosphorylated Tau, UCH-L1, and S-100B, all four of which had similar sensitivities at 75%. This sensitivity range at 6-month outcomes was still relatively inferior to the CT Rotterdam score (85%).
Conclusion: In this meta-analysis study, total Tau did not show any advantages in the severe TBI 6-month prognosis with GOS-E < 4, and phosphorylated Tau was similar in its sensitivity to other biomarkers such as GFAP and UCH-L1 and still inferior to the CT Rotterdam score. TBI biomarkers need stronger sensitivity evidence to support a more cost-efficient model.
Variation of Possion’s ratio of hard rocks during compression and an innovative determination method based on axial loading-unloading test
Authors: Yang Jianan , Fan Pengxian , Gao Hui , Dong Lu
Published: January 2024

The Poisson’s ratio of hard rock exhibits a marked stress dependence, which is contrary to its mechanical definition as an elastic constant. Thus, it is of great importance to determine the Poisson’s ratio through a reasonable method. To investigate the Poisson effect of multiple types of hard rocks (sandstone, basalt, granite, and marble), the uniaxial loading–unloading tests are carried out. The test results indicate that whether the tangent Poisson’s ratio or the average Poisson’s ratio, all gradually increases with the stress level. And the stress dependence of the average Poisson’s ratio under the unloading path is reduced, which is significant in the low and medium stress intervals. Appropriately increasing the number of loading–unloading cycles can also improve the stability of the average Poisson’s ratio to some extent. Based on this, a new method for testing the average Poisson’s ratio is proposed, which can effectively exclude the effect of irreversible displacement of rocks and improve the stability of the average Poisson’s ratio. The test procedure is simple and has good application prospects.
A study of using Haddon matrix to explore road environment improvement in school zones
Authors: Lin Wei-Quan , Liao Ying-Xin , Liu Hui , Ruan Hui-Hong , Sun Si-Yu , Liu Xiang-Yi , Fang Ying-Ying , Cui Min-Yan , Shen Ji-Chuan
Published: January 2024

Background
Road traffic-related injuries are a public health problem worldwide and could be extremely harmful to the lives of children. However, limited studies explore the risk factors of road traffic-related injuries in Haddon matrix to improve children road safety in China.
Methods
Based on literature review, we specified a framework of risk factors of road traffic-related injuries in Haddon matrix for schoolchildren pedestrians. Then, we formulated Haddon matrix under pre-intervention data including a baseline questionnaire survey and on-the-spot investigation toward schoolchildren and their parents of a primary school. According to the risk factors in Haddon matrix, some interventions were implemented in the school zones. After applying the interventions, we again conducted the questionnaire survey to compare the differences before and after the interventions, thereby to see the effect of implementation.
Results
We determined the risk factors of road traffic-related injuries for schoolchildren pedestrians of the school in Haddon matrix. Three main interventions were proposed according to the Haddon matrix and the possibility of implementation, including implementing road safety education, improving road safety environment near the school zones, and implementing Family-Police-School traffic assistant mode. The interventions effectively improve the road environment as 7.87% increase in schoolchildren who always felt safe when walked near the school, 15.46% increase in schoolchildren who thought it was easy to cross the road, and 11.25% increase in parents who agreed it was always safe for their children to walk to school alone (P < 0.05). Most participants were satisfied with the interventions and thought the interventions were worth promoting (P < 0.01).
Conclusions
Schoolchildren are vulnerable road users, and they are in high risks of road traffic-related injuries. Therefore, more future studies analyzing risk factors associated with road traffic-related injuries in Haddon matrix are required to better protect children from road traffic-related injuries and deaths.
Effects of integrated care on the quality of life and social relationships of older adults in South Korea
Authors: Lee Hyun-Ji , Yoo Ae Jung , Bang Hyo Jung , Choi Jae Woo
Published: January 2024

Objectives: This study examined the effects of integrated care on the subjective quality of life and social relationships of older adults in South Korea.
Methods: We combined data from the National Health Insurance Service and a survey of older adults across local governments participating in a pilot project for integrated care. To compare before and after participation in the pilot project, regression analysis was performed using the generalized estimation equations. The dependent variables were subjective quality of life and social relationships comprising the number of people who can help and the number of people met.
Results:
Older adults’ subjective quality of life significantly improved by 0.35 points, and the number of people who could help them significantly increased by 0.09 people after participation in the pilot project for integrated care. The results were similar when anayzed by sex and age. When analyzed by sex, subjective quality of life increased by 0.36 for men and by 0.34 for women. The number of people who can help increased by 0.13 for men and by 0.07 for women. As a results of analysis according to age, subjective quality of life significantly increased by 0.45 for older adults aged 65-74, by 0.31 for older adults aged 75 and over. The number of poeplle who can help significantly increased by 0.15 for older adults aged 65-74 and by 0.07 for aged 75 and over. The number of people met decreased slightly overall.
Discussion: Integrated care in Korea helped older adults feel more satisfied with their lives and alleviated their feelings of isolation by enabling them to live in their own homes and communities rather than in nursing hospitals or facilities. This study is the first to evaluate the achievements of an integrated care conducted in Korea in terms of older adults' quality of life and social relationships, and this can serve as the basis for developing integrated care in the future.
In-Situ Compressive Strength Assessment using CAPO-Test: A Study on Brick Chips based Concrete
Authors: Nasrin Umme Suraya , Khair Abul , Ahsan Raquib
Published: January 2024

This study presents the findings of an extensive investigation to evaluate the precision and reliability of a non-destructive CAPO test in estimating the in situ compressive strength of concrete made from machine-crushed brick aggregates. To estimate the compressive strength of concrete built from brick and stone aggregates for several target strengths at various ages, the CAPO test, core test, and standard cylinder test were used. The results of the core test and cylinder test are correlated with the CAPO pullout force, demonstrating a strong relationship between pullout force and compressive strength. The results suggest that the CAPO test displays estimated strengths ranging from 5–17% of the cylinder strength and 0–6% of the core strength for concrete containing brick chips. The study validates the CAPO test's reliability in conducting in-situ concrete strength assessments.
Bayesian Approach to Improve Consistency of the Individual Pairwise Comparison Matrices
Authors: Hinc Tomasz , Kliber Agata
Published: January 2024

This research addresses the problem of multi-criteria decision-making, using an analytical hierarchy process (further: AHP). In such a process, individuals present their preferences in the form of pair-wise comparison matrices (further: PCM). The goal of the AHP is to extract the ordered priority vector from such PCMs. The quality of the extracted priority vectors depends on the consistency of individual matrices. In the article, we propose a new approach to improve the consistency of the individual PCM. Using a Bayesian approach, we extend the work of Lin and Kou (2015). Instead of a univariate normal model with conjugate priors, as a first alternative, we apply more flexible non-conjugate priors. In the next two approaches, we use matrix normal distributions, relaxing the assumption of non-correlated error terms resulting from the imprecision of the judgements. We run the same experiment as Lin and Kou (2015) and compare the consistency of the obtained matrices with the results of the original paper. In each case, the consistency is higher (according to consistency ratio and Euclidian distance), while the ordering of preferences remains unchanged.
Effect of cylindrical micro-pit texture on the performance of misaligned radial journal bearing
Authors: Li Jianqiang , He Zhenpeng , Wang Yubo , Qian Junze
Published: January 2024

In order to study the influence of the circumferential distribution position, axial proportion, depth, inclined angle and area rate of cylindrical micro-pit texture on the lubrication and tribological performance of misaligned radial journal bearing, the mathematical model of friction lubrication of journal bearing is established based on the Reynolds equation, and the oil film pressure under the influence of different micro-pit texture parameters is solved iteratively by finite difference method, and the bearing load carrying capacity, friction force and end leakage of bearing under different texture parameters are calculated. The results are as follows: the bearing load carrying capacity is higher when the cylindrical micro-pit texture is distributed in the boost area and the axial ratio is around 55%; compared with smooth bearing, fully textured bearing and bucking zone micro-pit texture bearing, the coefficient of friction of journal bearing of the micro-pit texture in the boost area journal bearing is lower, and there exists an optimal axial proportion and depth of texture, which make the best friction and lubrication performance of the journal bearing; the micro-pit texture has the dual possibility of weakening and enhancing the bearing load carrying capacity, and the existence of the optimal circumferential and axial ratio, depth and inclined angle of the micro-pit texture make the bearing have higher load carrying capacity with less friction coefficient; the area ratio of cylindrical micro-pit texture is linearly correlated with bearing capacity and friction force; the smaller the degree of misalignment of the bearing, the more beneficial it is to improve the friction and lubrication performance of the bearing when machining suitable parameters of micro texture on the smooth bearing surface.
Extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: A propensity score matching, observational study
Authors: Shih Hong-Mo , Lin Wei-Jun , Lin You-Cian , Chang Shih-Sheng , Chang Kuan-Cheng , Yu Shao-Hua
Published: January 2024

Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly performed as an adjunct to conventional cardiopulmonary resuscitation (CCPR) for out-of-hospital cardiac arrest (OHCA). However, the specific benefits of ECPR concerning survival with favorable neurological outcomes remain uncertain. This study aimed to investigate the comparative advantages of ECPR over CCPR in the management of OHCA. We conducted a retrospective cohort study as a single center involved OHCA patients between January 2016 and May 2021. Patients were categorized into ECPR or CCPR groups. The primary endpoint assessed was survival with favorable neurological outcomes, and the secondary outcome was survival rate. Multivariate logistic regression analyses, with and without 1:4 propensity score matching (PSM), were employed to assess ECPR’s effect. In total, 1792 patients were included: 111 underwent ECPR, and 1681 received CCPR. Compared to the CCPR group, the ECPR group exhibited notably higher rates of sustained return of spontaneous circulation (ROSC) (93.7% vs. 27.7%; p < 0.001), survival to discharge (38.7% vs. 13.9%; p < 0.001), and survival with favorable neurological outcome (22.5% vs. 6.0%; p < 0.001). Multivariate logistic regression analysis demonstrated that ECPR correlated with increased odds of survival with favorable neurological outcome (adjusted odds ratio: 1.79; 95% confidence interval (CI): 1.03–3.11; p < 0.037). Following PSM, the ECPR group showed significantly elevated odds of survival with favorable neurological outcomes (adjusted odds ratio: 2.22; 95% CI: 1.20–4.11; p = 0.010). This study demonstrated that in comparison to CCPR, ECPR may improve survival rates and odds of favorable neurological outcomes in OHCA patients.
Real-Time Three-Dimensional Transesophageal Echocardiography Outperforms Three-Dimensional Printing in Detecting Multiple Perivalvular Leaks after Mitral Valve Replacement：A Case Report and Literature Review
Authors: Wang Zhirong , Wan Qiuxian , Fan Chengming , Ai Qi , You Hong , Wu Qin
Published: January 2024

To report on a patient who developed multiple perivalvular leaks (PVLs) after a mechanical mitral valve replacement, and how clinicians successfully used real-time three-dimensional transesophageal echocardiography combined with 3D printing to complete transapical perivalvular closure. Additionally, we reviewed the literature to explore the advantages and disadvantages of multimodal imaging for perivalvular leaks.The case is a 63-year-old female patient with a history of rheumatic heart disease underwent mitral mechanical valve replacement, tricuspid valvuloplasty, and left atrial folding four years ago. She presented with shortness of breath and TTE revealed two PVLs. Real-time 3D TEE combined with 3D printing technology was used to create a 3D model of the patient's heart, which allowed for precise identification of the PVLs. The transapical occlusion was successfully performed under the guidance of 3D TEE.The patient also showed good recovery during postoperative follow-up.The combination of 3D ultrasound and color mapping is advantageous in identifying and describing multiple PVLs. The use of 3D TEE combined with 3D printing technology provides a "double protection" in closure of PVLs, allowing for more accurate and precise placement of closure devices. Multimodal imaging plays a critical role in the management of PVLs, providing clinicians with essential information for successful treatment.
Jnk1 and Downstream Signalling Hubs Regulate Anxiety-like Behaviours in a Zebrafish Larvae Phenotypic Screen
Authors: Hong Ye , Sourander Christel , Hackl Benjamin , Patton Jedidiah , John Jismi , Paatero Ilkka , Coffey Eleanor
Published: January 2024

Current treatments for anxiety and depression show limited efficacy in many patients indicating that research into new underlying mechanisms is needed. Inhibition of JNK1 has been shown to evoke an anxiolytic-and antidepressant-like phenotype in mice however the downstream effectors that elicit these behavioural effects are unknown. Here we employ a zebrafish (D. Rerio) larvae behavioural assay to identify an antidepressant-/anxiolytic-like phenotype based on 2759 measured stereotypic responses to clinically proven antidepressant and anxiolytic (AA) drugs. Employing machine learning, we classify an AA phenotype from behavioural features measured during and after a startle battery in fish exposed to AA drugs (fluoxetine, imipramine, diazepam, lithium chloride, ketamine). We demonstrate that structurally independent JNK inhibitors replicate the AA classification with high accuracy, consistent with findings in mice. We go on to identify signalling hubs downstream from JNK1 by comparing phosphoproteome data from wildtype and Jnk1-/- mouse brains, and test these hubs as possible mediators of the AA phenotype in zebrafish larvae. Among these, we find that AKT, GSK-3, 14-3-3ζ/ε and PKCε, when pharmacologically targeted, phenocopy clinically proven AA drugs. This assay shows promise as an early phase screening for compounds with anti-stress-axis/anxiolytic-like properties, and for mode of action analysis.
Reservoir damage mechanism and “Double protection” drilling fluid of tight sandstone gas reservoir in central SiChuan Basin
Authors: Fan Yu , Huang Weian , Guo Jianhua , Bai Ruiyu , Lin Jiang , Wang Zengbao
Published: January 2024

It is very important to clarify the reservoir damage characteristics and damage characteristics and damage mechanism of tight sandstone gas reservoirs in Jinhua-Zhongtai mountain area of central SiChuan Basin, and put forward the technical countermeasures of “Double protection” drilling fluid to protect the reservoir and the environment, which is very important for the efficient well construction in this area. Through X-ray diffraction, scanning electron microscopy, casting thin sections and other testing methods, the mineral composition and microstructure characteristics of the block were analyzed, and the potential damage factors of the reservoir were clarified. Based on the sensitivity evaluation, it was revealed that the overall sensitivity damage of the block was weak. The main damage type was salt-sensitive damage, and the critical salinity was 9472.5 mg/L. On the basis of the environmental protection drilling fluid system used in this block, the surfactant which can effectively prevent gas invasion and reduce surface tension is selected, and the “Double protection” drilling fluid system is constructed. Through comprehensive performance test and reservoir protection performance evaluation, the core permeability damage rate of the optimized drilling fluid system is reduced from 88.77–18.66%, and the cuttings recovery rate is increased to more than 66%, and the cuttings expansion rate is reduced to less than 3.2%, which can effectively solve the problem of reservoir damage in drilling in Jinhua-Zhongtai mountain block in central Sichuan.
Numerical analysis of flow past five inline square cylinders at various gap spacing with Strouhal number
Authors: Manzoor raheela , perveen Sajida , Akhtar Yasmeen , Panezai Neelam
Published: January 2024

A two dimensional numerical study is carried out for flow past five inline square cylinders of similar size ‘D’ at Re = 150 for studding flow behavior. The gap spacing (g) between the cylinders is varied from g = 0.25–5. The flow structure mechanism is analyzed in terms of vorticity contour visualization, time-history analysis of drag and lift coefficients and physical parameters. Under the effect of gap spacing, four distinct flow modes are identified. These are, i). Shear layer reattachment flow mode, ii). Semi-developed irregular vortex shedding flow mode, iii). Fully-developed two rows vortex shedding flow mode and iv). Two rows single bluff body flow mode for cylinders C1-C5. In Force Statistics, the values of Cdmean, Cdrms, Clrms and St are calculated. The mean drag coefficient represents mixed trend by increasing the values of gap spacing for cylinders C3, C4 and C5. The maximum value of Cdmean is found at g = 5 for cylinder C1, that is 1.4594, while the minimum value of Cdmean is for cylinder C3 at g = 0.25. There may also observed some negative values of Cdmean for cylinder C2 at g = 0.25–2.25 and for cylinder C3 at g = 0.25–1.25 due to effect of thrust. Furthermore, St shows increasing behavior at small and large gap spacing i.e = 0.25–0.75 and = 1.5-5. While decreasing behavior at moderate gap spacing. The greatest value of Strouhal number is examined at g = 5 for cylinder C5, i.e 0.1521.
N-acetylaspartate from fat cells regulates postprandial body temperature
Authors: Felix Jessica , Saha Pradip , de Groot Evelyn , Tan Lin , Sharp Robert , Anaya Elizabeth , Li Yafang , Quang Holly , Saidi Nooshin , Abushamat Layla , Ballantyne Christie , Amos Christopher , Lorenzi Philip , Klein Samuel , Gao Xia , Hartig Sean
Published: January 2024

N-acetylaspartate (NAA), the brain's second most abundant metabolite, provides essential substrates for myelination through its hydrolysis. However, activities and physiological roles of NAA in other tissues remain unknown. Here, we show aspartoacylase (ASPA) expression in white adipose tissue (WAT) governs systemic NAA levels for postprandial body temperature regulation. Proteomics and mass spectrometry revealed NAA accumulation in WAT of Aspa knockout mice stimulated the pentose phosphate pathway and pyrimidine production. Stable isotope tracing confirmed higher incorporation of glucose-derived carbon into pyrimidine metabolites in Aspa knockout cells. Additionally, serum NAA positively correlates with the pyrimidine intermediate orotidine and this relationship predicted lower body mass index in humans. Using whole-body and tissue-specific knockout mouse models, we demonstrate that fat cells provided plasma NAA and suppressed postprandial body temperature elevation. Furthermore, exogenous NAA supplementation reduced body temperature. Our study unveils WAT-derived NAA as an endocrine regulator of postprandial body temperature and physiological homeostasis.
Developments in the molecular basis of heterosis to evaluate the quality and yield production of F1 garden peas using novel genetic resources
Authors: Aman Faiza , Basit Abdul , Ara Neelam , Shah Syed Mehar Ali , Khan Waleed , Khan Ayesha , Shah Syed Tanveer
Published: January 2024

The utilization of novel germplasm in hybridization programs presents a valuable opportunity for crop breeders to explore the potential of heterosis in key agronomic traits. This study aimed to evaluate the extent of heterosis for maturity and yield characteristics by employing new pea accessions in hybridization. The experimental material consisted of 51 F1 pea hybrids obtained through crossbreeding of parents in all possible combinations. The F1 cross UAP-47×UAP-29 demonstrated the highest metrics for seeds per pod (12.3), 100-green seed weight (g), 100-green pod weight (g), and green pod yield (tons ha− 1). Similarly, the F1 hybrids Green Gold×UAP-47 and UAP-29×UAP-47 exhibited the greatest pod length (cm) and pods per plant (66.0), respectively. The most noteworthy negative better-parent heterosis (-30.9%) for days to first picking was evident in the UAP-29×Leena Pak cross. Meanwhile, the F1 cross UAP-7×UAP-35 showcased the highest positive better-parent heterosis (%) for pods per plant. UAP-29×UAP-47 displayed the highest better-parent heterosis (%) for pod length. The F1 hybrid Leena Pak×UAP-31 exhibited significantly better parent heterosis (%) for seeds per pod. Similarly, the cross UAP-32×UAP-7 displayed remarkably better parent heterosis (%) for 100-green seed weight. For 100-green pod weight, the Leena Pak×UAP-31 cross demonstrated the highest better-parent heterosis (%). The cross combination UAP-47×UAP-29 showcased the maximum better-parent heterosis for green pod yield (%). The segregating generations from crosses like UAP-29×Leena Pak for early maturity and those such as UAP-29×UAP-47, UAP 47×UAP-29, UAP-7×UAP-35, Leena Pak×UAP-31, and UAP-32×UAP-7 for yield traits could be advanced for the development of early maturing and high-yielding pea cultivars.
Predictive Value of ICU Patients' Mortality Based on Serum Ionized Ca Rather Than Total Ca in Acute Ischemic Stroke: Insights from MIMIC-IV Database Analysis
Authors: Wu Caijiao , Li Xiaorong , Li Jiaxing , Huo Ruiling , zhao huihan , Ying Yanping
Published: January 2024

Background
While serum Ca has proven to be a reliable predictor of mortality across various diseases, its connection with the clinical outcomes of ischemic stroke (IS) remains inconclusive. Our research aimed to explore the relationships between serum total Ca (tCa) and serum ionized Ca (iCa) and mortality among acute IS (AIS) patients.
Methods
We gathered data from 1773 AIS patients in the Medical Information Mart for Intensive Care Database IV, including baseline demographic data, comorbidities, vital signs, laboratory-based data, and scoring systems. Endpoints for the study encompassed 30-d, 90-d, and 365-d all-cause mortalities. Employing restricted cubic spline Cox regression, we explored potential nonlinear relationships between admission serum iCa and tCa levels and mortality. Participants were categorized into four groups based on serum iCa and tCa quartiles. Multivariable Cox regression analysis was then conducted to evaluate the independent association of iCa and tCa quartiles with all-cause mortality.
Results
The restricted cubic spline revealed a U-shaped association between iCa and 30-d and 90-d mortality (P < 0.05), while the relationship between iCa and 365-d mortality was linear (P < 0.05). After adjusting for confounders, multivariable Cox analysis demonstrated that the lowest serum iCa level quartile was independently associated with increased risks of 30-d, 90-d, and 365-d mortality. Similarly, the highest serum iCa level quartile was independently associated with increased risks of 30-d and 90-d mortality, but not 365-d mortality. Notably, serum tCa level showed no association with increased risks of 30-d, 90-d, and 365-d mortality.
Conclusions
Our findings suggest that serum iCa, rather than tCa, is linked to ischemic stroke prognosis. Both high and low serum iCa levels are associated with poor short-term prognosis, while only low serum iCa is associated with poor long-term prognosis in AIS patients.
Concurrent Scaling: Evaluating AWS Lambda Performance through Load Testing
Authors: Balakrishna Balasubrahmanya
Published: January 2024

In the dynamic environment of serverless computing, efficient concurrency management and reasonable utilization of load testing techniques closely correlate with performance improvement. This paper, aiming to offer practitioners practical insights and contribute to the theory of serverless architectures, intends to illuminate the intricate connection between concurrency settings and load testing results within AWS Lambda. The paper thoroughly explores load testing and concurrency control in AWS Lambda. We specified a range of concurrency settings, including provisioned and unreserved, and meticulously selected representative Lambda functions. We subjected these functions to diverse simulated workloads using industry-standard load testing methods. We methodically measured and recorded performance metrics, including response times, throughput, and resource consumption, to identify significant patterns and correlations. The article shows discrete performance quirks associated with various concurrency settings by exposing necessary trade-offs and optimization techniques. In addition to providing helpful advice for developers and architects, this research advances our theoretical knowledge of how concurrency affects the performance of serverless functions. Focusing on the unique features of AWS Lambda, the need for customized load-testing approaches is emphasized, offering practitioners practical advice on how to improve the efficiency and scalability of their serverless apps. This article uniquely enriches the confluence of theory, practice, and policy in serverless computing. Defining the complex relationship between concurrency and load testing and providing a platform for future research enhances theoretical underpinnings. The results provide developers and architects with explicit guidelines on configuring concurrency settings to meet workload needs. Additionally, the study supports a sophisticated approach to load testing and concurrency control in the larger context of cloud computing, which adds to policy discussions surrounding serverless best practices.
Environmental assessment by vulnerability analysis of water intended for human consumption in urban environments using GIS methods: Case of the N'djili River (Kinshasa/DR Congo)
Authors: MUFUNGIZI Innocent , LOOLA Ruben , AKILIMALI Aymar
Published: January 2024

The Water Distribution Administration of the Democratic Republic of Congo (REGIDESO) continues to face numerous problems linked in particular to unregulated human activities throughout the river in general and in particular around the watershed of the N River 'djili. Domestic and industrial activities, agricultural activities, commercial activities, and road transport contribute to the pollution of the N'djili River and groundwater. Contaminated water constitutes a health danger for the population because it accentuates water-borne diseases such as cholera, diarrhea, and even malaria, which caused a total of 619,000 deaths in Africa in 2021. It is with this motivation that we are given the task of carrying out an environmental study to analyze the vulnerability of water in this area in order to propose a Water Security Plan (PSG). During the environmental investigation, we listed several sources of water contamination, mainly chemicals used in agricultural areas to increase profitability, domestic wastewater, industrial wastewater, and feces. Subsequently, we calculated the water protection perimeters of the N'djili River and the drilling observed in the study area using geographic information systems (GIS) techniques. It was noted that the immediate protection perimeter is occupied by activities likely to pollute water; this is the case for the close protection perimeter. To combat these problems, the government of the Democratic Republic of Congo must put in place a solid water safety plan, which will help combat several consequences that these problems present for the health of the population.
A Metanalysis of Burden of Stroke for HIV population in Africa: Current and Future perspectives
Authors: Zulu Francis , Webster Munengo , Sandra Situmbeko , Musonda Banda , Mavis Bwalya , Moonga Mirriam , Bwalya Nsofwa , Spelile Siamulandabala , Patience Phiri Mwanida , Shamapongo Shambana
Published: January 2024

Objective
Information on the current burden of stroke for HIV population in Africa is limited. The aim of this review was to comprehensively examine the current and future burden of stroke for HIV population in Africa. Methods: We systematically reviewed the available literature (PubMed) from January 1960 to September 2022 on stroke for HIV population in Africa. Percentage change in age-adjusted stroke incidence among HIV population in Africa was obtained from peer reviewed articles and entered in a data capturing tool called systematic literature HIV and Stroke review summary table. Results: Studies revealed that the prevalence of stroke among HIV population in Africa varies from country to country with the lowest being 2.3% and the highest 18%.
Conclusion
While the available study data and evidence are limited, the burden of stroke for HIV population in Africa appears to be increasing and more significantly among the young population of average age 46 years.
Successive Isolation, Identification and Antimicrobial Susceptibility Pattern of Bacteria Involved in the Processing of two Traditionally Fermented foods (Okpehe and Ogiri)
Authors: Ogbu J.C. , Ugoh S.C.
Published: January 2024

This research focuses on the Successive isolation and Antimicrobial Susceptibility Pattern of bacteria involved in the processing of two traditionally fermented foods (Okpehe and Ogiri). Successive Isolation of the bacteria was done on the 24 hour, 48 hour, 72 hour, 96 hour and 120 hour of the Fermented samples by innoculating the samples on Nutrient Agar, MacConkey Agar and Mannitol Salt Agar. Some Biochemical tests (Gram staining, citrate, Oxidase and Catalase) was done and the organisms obtained were Staphylococcus aureus, Escherichia coli and Staphylococcus epidermis.
WITHDRAWN: The economic effect of sex and germinated sprout feed on the growth performance of new hybrid broiler chickens for environmental adaptation in Egypt
Authors: Arafa Abdelsatar
Published: January 2024

In this study, a total of 360 one-day-old birds (180 males and 180 females) of a new hybrid broiler (WINZY line 105) were raised to 8 weeks of age. Birds were randomly taken to be similar in body weight (33.9 ± 0.58) and divided into four groups (90 birds in each group) in three replicates (30 birds/replicate). The experimental groups involved a 2X 2 factorial arrangement, two sex groups (male (M) and female (F)), and two types of rations (basal diet from one day up to 56 days and basal diet plus germinated sprouts from 28 to 56 days of age). The birds were reared in controlled, semi-closed houses in winter, aiming to simulate the effects of sex and ration type on productive, physiological and economic efficiency for environmental adaptation. Sex is the main determinant of broiler performance. Compared with females, males had significantly (P≤01) greater body weight, body weight gain, feed intake, feed conversion, carcass weight and economic efficiency. Body weight, feed intake and feed conversion gain were improved for the chicks fed a basal diet plus germinated sprout feed in comparison to those of the other groups fed only basic rations. The carcass yield, abdominal fat percentage, total antioxidant capacity, cholesterol and low-density lipoprotein content were greater for males fed a basal diet plus germinated sprouts than for those in the other groups, and the net return economic efficiency percentage was also greater. In conclusion, the use of germinated sprout feed improved birds' productivity and physiologic and economic efficiency, especially in males. This work highlighted the importance of breeding characteristics and feeding type on the growth performance of broilers and will help to select and improve their traits against environmental stresses.
Efficient separation of cadmium from cobalt-rich solutions using cyanex301 and P204/P507
Authors: Qian Zhen , Li Chongyang , He Limin , Chen Hufei , Peng Yanmei , Shi Qilong , Xiong Xueliang , Xia Xinbing , Wang Changhong
Published: January 2024

The presence of cadmium (Cd) in ternary batteries is a known detriment to both their service longevity and cycling performance. Traditional methods for reducing Cd levels in cobalt (Co) sulfate solutions can be effective but often result in significant losses of Co. This study introduces an enhanced dual-extractant system that combines 5% (V/V) di-2-ethylhexyl phosphoric acid (P204) with 5% (V/V) bis (2,4,4-trimethylpentyl) dithiophosphinic acid (Cyanex301) to effectively lower Cd content without substantial Co depletion. Conducted at a pH of 1.8 with a 1:1(V/V) organic-to-aqueous phase ratioat 25 °C for 10 minutes, our approach achieved a 99.99% extraction efficiency for Cd and limited Co extraction to just 0.53%. Subsequent stripping processes utilized 1 M sulfuric acid and 6 M hydrochloric acid to recover 87.13% of Co and 95.11% of Cd. An efficient process roadmap operated at optimized condition was constructed for plant-wide treatment of the cobalt sulfate solution containing Cd. The innovative results hold the potential to accelerate advancements in secondary resource recycling, especially Cd and Co.
The match between higher education skill supply and employers’ skill needs in Ethiopia
Authors: Teshome Asmera
Published: January 2024

The purpose of this study investigated the match between higher education skill supply and employers’ skill needs, with a special focus on engineering graduates in Ethiopia. Using an embedded mixed method design, the study analyzed both primary and secondary data on the match between higher education supply and employers needs for discipline-specific, technical, interpersonal, and generic skills. 275 research participants recruited from employees, employers, higher education instructors, and decision-makers took part in the study. The findings of the study revealed that higher learning institutes moderately equip graduates with discipline-specific skills, technical skills, interpersonal skills, and generic skills, while employers’ need for these skills is high. These indicate existence of a significant mismatch between higher education skill supply and employers’ needs, which was higher for technical and generic skills than interpersonal and discipline-specific academic skills. Such mismatch between higher education skill supply and employers’ skill needs negatively affect economic performance and social security through increasing rate of graduates’ unemployment. To mitigate such problems, higher learning institutes could conduct real employers’ needs assessments before preparing training curricula and need to update training styles and contents accordingly. The skills employees acquire at work, factors contributing to the mismatch between skill supply and employers’ needs, and impacts of skill mismatch could be future research areas.
Exploring Teacher Efficacy in Integrating Robotics and Concept-Based Approach for Teaching Chemistry Using the Periodic Table
Authors: MHLONGO THABO
Published: January 2024

This study investigates the efficacy of integrating robotics and a concept-based approach in teaching chemistry, with a focus on the periodic table. Utilizing Bandura's social-cognitive theory and situational efficacy, a multiple-case study design involves four purposefully selected chemistry teachers. Data, gathered through classroom observations and semi-structured interviews, highlights how teachers' conceptions, beliefs, and characteristics shape their integration of robotics in chemistry education. Positive outcomes include heightened learner interest, improved understanding, and increased motivation. The study emphasizes the value of interdisciplinary learning, inquiry-based activities, and continuous professional development for successful integration. The findings provide insights for enhancing teaching efficacy and improving learning outcomes in chemistry education, guiding future research and professional development initiatives.
The Correlation between University Students' Personality and Mastery of Writing Skills
Authors: Rahardi Panggih , Vina Oktaviana  , Tri Himatul Aliyah  , Afi Normawati
Published: January 2024

This study seeks to examine whether university students' personalities and writing skills are correlated. This study used correlational research as its methodology. The researchers examined two variables, university students' personality and writing skills, to establish a statistical correlation between them. This study's respondent sample consists of forty students majoring in English education. This study was conducted in the English Education Department of Universitas Tidar's Faculty of Teacher Training and Education. Using an International Personality Item Pool (IPIP) questionnaire makes it simple to ascertain the personality scores of each respondent, regardless of whether they are high-extroversion or low-extroversion learners. In addition, the participants' writing skills were shown by their mid-semester essay writing course test scores. Quantitative data exists for both extroversion and writing scores. Therefore, Pearson product-moment and SPSS were used to analyze the data. Based on the results of this study, the researchers conclude that there is only a weak correlation between university students' personalities and their mastery of writing skills. Because the findings of this study contrast with those of other studies, it is hoped that further research will be conducted to provide a more nuanced and comprehensive understanding.
Using Flash Cards to Improve the Vocabulary Mastery of XI Graders at SMA N 1 Ngaglik
Authors: Permani Kezia Intan , Yulia Made Frida , Rahayu Dewi
Published: January 2024

Vocabulary becomes one of the most essential aspects in learning English. However, since English was a foreign language in Indonesia, students had lack of vocabulary that made it difficult for them to learn English well. Teachers needed to help the students in mastering their vocabulary by using an interesting media. Therefore, this study aimed to investigate the use of flash cards as a learning media to improve students’ vocabulary mastery of XI Science 3 at SMA Negeri 1 Ngaglik. The participants of this study were thirty-two students from XI Science 3 at SMA Negeri 1 Ngaglik. Classroom Action Research was employed with 2 cycles. The data was collected using the pretest and posttest, and the questionnaires. The results showed that implementing flash cards in the learning process enhanced students’ vocabulary mastery. It could be proven based on the average of students’ scores which were 75.62 in the pretest, 94.68 in the posttest of cycle 1, and 98.12 in the posttest of cycle 2. Another thing, the results indicated that using flash cards gave many advantages for the students. By using flash cards, it was easy for students to remember the words, understand the meaning of the words, understand the synonym and definition of the words, and enhanced new vocabulary. Moreover, flash cards increased students’ motivation in learning vocabulary. From the results, it could be concluded that applying flash cards could improve students’ vocabulary mastery.
Nexus of business intelligence capabilities, firm performance, firm agility, and knowledge-oriented leadership in the Jordanian high-tech sector
Authors: Khawaldeh Khaldoon , Alzghoul Amro
Published: January 2024

The objective of this study is to investigate the influence of business intelligence capabilities on firm performance, with a specific emphasis on the role of firm agility and the impact of knowledge-oriented leadership within this association. The paper used a quantitative approach using data from a sample of 237 participants randomly chosen from a pool of 34 high-tech companies in Jordan. The study included a diverse range of participants, including individuals occupying various professions, such as managers, supervisors, analysts, and other relevant positions. This broad sample was selected to provide a full comprehension of the influence of business intelligence capabilities on firm performance. This approach allowed for the inclusion of various organizational levels and views, therefore capturing a wide range of insights. The study used the partial least squares modeling technique to analyze cross-sectional data to investigate the proposed model. The findings of this analysis, with a statistically significant p-value of less than 0.05, elucidate that the capabilities of business intelligence exert a substantial influence on the agility of a firm, subsequently affecting the firm’s overall performance. Moreover, firm agility mediates the correlation between its business intelligence capabilities and firm performance. Additionally, knowledge-oriented leadership moderates the effect of business intelligence capabilities on firm agility.
Gojek Accelerate Economic Recovery through the Digitalization of MSMEs in Makassar
Authors: Karim Abdul , Asrianto Asrianto , Ruslan Muhlis , Said Miah
Published: January 2024

It was a qualitative descriptive research to determine the role of the digital economy in Makassar City’s economic growth. Data were collected from some websites in Indonesia, and analysed by using NVivo 10 software. The results indicate the acceleration of the digital transformation of MSMEs in Makassar City could not be separated from the support of digital platforms. Before the pandemic, the digital economy, namely Gojek, contributed to economic growth. Makassar City's economy has experienced an increase in MSME turnover registered on social sellers GoFood, GoPay, and GoSend. The digital economy plays a vital role in driving the wheels of the Makassar City economy. In 2021, Gojek and GoTo Financial were estimated to contribute around IDR 4,6 trillion, or 3% of Makassar City's Gross Regional Domestic Product (GRDP). Since data reveals that Gojek Food is encouraging, Gojek is also accelerating digitization and financial inclusion for MSMEs. MSMEs are going digital for the first time (87%) and are using non-cash payments (51%). 37% of GoRide partners and 22% of GoCar partners have saved regularly since joining Gojek. According to estimates, the Gojek ecosystem contributes IDR 249 trillion, or 1,6% of Indonesia’s GDP—resilience and recovery speed through increased revenue, mainly for MSMEs in the Gojek ecosystem. During the pandemic, consumer loyalty aided economic recovery at the national and regional levels.
Network Externality as a Mediator on Business Growth:
Authors: Furinto Asnan , Selamet Thamrin , Heriyati Pantri , Mursitama Tirta Nugraha , Ichsan Mohammad
Published: January 2024

The Multilevel Marketing (MLM) business became a more dynamic and competitive environment that drove companies to be sustainable in their business. However, the practices were sometimes perceived to be challenging by some of them. The research aimed to determine the role of network externality on Business Growth in the network marketing industry, often called MLM industry. With a non-probability sampling approach, the data were collected using structured questionnaires that were sent through emails or hardcopy. The collected data were analyzed using the PLS-SEM method with SmartPLS software. The results reveal that network externalities fully mediate both digital adoption capabilities and strategic agility to sustainable business growth. Meanwhile, network externality partially mediates the perceived product advantage to sustainable business growth. The result shall be taken into action by the companies as a key strategy in performing their business.