bluuebunny/crossref_metadata_2025 huggingface dataset:
Consumo alimentar de adolescentes: Validação e calibração de um questionário de frequência alimentar em estudo com amostragem complexa
Authors: Barroso Rosemary da Rocha Fonseca , Aquino Rosana , Amorim Leila Denise Alves Ferreira
Published: June 2021

Estudos sobre padrões alimentares dependem da validade dos métodos, como o questionário de frequência alimentar (QFA), para estimar consumo alimentar de longo prazo, que pode ser superestimado e o método precisa ser validado. Questiona-se se estudos de validação aninhados a estudos com desenho amostral complexo (DAC) deveriam ignorar a dependência dos dados. Este estudo objetiva validar o QFA aplicado a adolescentes escolares e estimar os fatores de calibração em um estudo com amostragem complexa. A validade do QFA é testada frente a registros alimentares (RA) aplicados a 85 adolescentes em um estudo com DAC, com estimação dos fatores de calibração (λ) para energia, nutrientes e grupos alimentares (GA). Coeficiente de correlação intraclasse foi calculado; diferenças médias foram comparadas via modelagem, e foram realizadas análises de concordância. As médias entre os métodos diferiram para energia e nutrientes (p<0,05), mas quatro GA foram similares. Limites de concordância não se mostraram aceitáveis para os nutrientes. Coeficientes de correlação de concordância de fibras, zinco e ácidos graxos, ajustados pela energia, variaram de 0,16 a 0,22 e para os GA variaram de 0,07 a 0,36. Os fatores de atenuação corroboraram as diferenças (λ<0,40). O QFA apresentou validade relativa, sobretudo para os GA e λ aproximou as estimativas do QFA ao RA, sendo relevante quando nutrientes são usados em análises epidemiológicas. O ajuste das análises pelo DAC confirmou que a estrutura de dependência dos dados deve ser considerada, mesmo em estudos de validação, devendo-se evitar tratar tais dados como se fossem oriundos de amostra aleatória simples.
Diabetes mellitus e hipertensão arterial em pacientes com insuficiência renal crônica em diálise: Revisão integrativa
Authors: Silva Tayná Kelle da
Published: June 2021

Objetivo: Analisar as evidências científicas a cerca do diagnóstico de Hipertensão arterial (HAS) e Diabete Mellitus (DM) em pacientes portadores de insuficiência renal crônica em diálise no Brasil? Método: Foi realizada uma revisão integrativa da literatura, conduzida por uma revisora nas bases de dados PubMed, Web of Science, SciELO e LILACS. Foram estabelecidos como critérios de elegibilidade: estudos observacionais originais redigidos em português, inglês ou espanhol, que avaliaram a prevalência da associação entre a DM e HAS na população brasileira. Resultado: A nefropatia diabética (ND) é uma complicação crônica do diabetes que afeta os brasileiros em torno de 20 a 30% das pessoas com DM, sendo responsável por aproximadamente metade dos casos de insuficiência renal nos pacientes em diálise no Brasil. A hipertensão arterial ou primária é descrita como uma das causa mais prevalente de DRCT. Foi notado um percentual de concordância baixo (15%) para HAS.
Efeito analgésico da música durante a fotocoagulação retinal a laser em diabéticos: Um estudo cruzado, randomizado e controlado por placebo
Authors: Ribeiro Núbia Franca Passos , Ribeiro Caíque Jordan Nunes , Oliveira Aline Láyra Carvalho , Dias Emilly Mayara Feitoza , Santos Moniery da Silva , Santos Allan Dantas dos , Santos Eduesley Santana , Morais Fábio Barreto , Melo Gustavo Barreto , Ribeiro Maria do Carmo de Oliveira
Published: June 2021

Objetivo: Avaliar prospectivamente o efeito analgésico da música de preferência do paciente com retinopatia diabética que foram submetidos à fotocoagaluação retiniana a laser (FRL). Metodologia: Trata-se de um ensaio clínico controlado, randomizado, cego e crossover de dois períodos. Participaram vinte pacientes (40 olhos) com retinopatia diabética proliferativa que foram submetidos à FRL. A escuta musical de preferência do paciente antes e durante a FRL foi a intervenção não farmacológica testada. O grupo controle (GC) foi composto por pacientes que receberam apenas o tratamento farmacológico padrão e o grupo experimental (GE) por aqueles que receberam a intervenção associada ao tratamento farmacológico padrão. A dor foi mensurada pela Escala Numérica Verbal. As diferenças dos escores de dor foram examinadas por meio dos testes Aligned Rank Transformed ANOVA, Mann-Whitney U e de Wilcoxon. O tamanho do efeito das diferenças foi avaliado usando Tamanhos de Efeito Rank Bisserial e Parcial Square. Resultados: Os participantes eram predominantemente do sexo masculino (60%), adultos (57,4±9,1 anos), com comorbidades (65%), com deficiência visual ≥ 1 ano (65%). Os participantes que ouviram música apresentaram menores escores de dor (GE: 4,80±2,46) comparados aos que não ouviram (GC:6,75±1,59; p=0,013). A aplicação de música de preferência do paciente mostrou um grande tamanho do efeito analgésico (η²=0,189). Conclusão: Ouvir música de preferência do paciente, associada à analgesia padrão, é eficaz no alívio da dor aguda relacionada à FRL e deve ser incorporada à prática clínica para o tratamento multimodal da dor nesse procedimento.
A utilização do aplicativo “física interativa” no ensino de Física
Authors: Ferreira Alexandre Jader da Silva , Costa Renato Araujo da , Rocha Adriano Santos da , Feitosa Robson de Sousa , Rocha Elaine Cristina Medeiros da , Amador Davi Henrique Trindade , Rocha João Augusto Pereira da
Published: June 2021

Este trabalho aborda o uso do aplicativo “Física Interativa” que pode ser instalado em smartphones que utilizam o sistema Android, e além disso, pode ser utilizado como ferramenta de ensino de Física em sala de aula. Assim, esta pesquisa objetivou analisar o uso do aplicativo “Física Interativa” como recurso metodológico no ensino de Física, assim como identificar se os smartphones podem auxiliar no processo ensino aprendizagem, aumentando a concentração sobre os conteúdos estudados. A pesquisa de base qualitativa, lançou mão do estudo de caso com dados quantitativos e qualitativos, considerando como instrumentos de coleta de dados, a observação e a aplicação de entrevista com questões fechadas. A investigação foi realizada especificamente em uma turma de primeiro ano do ensino médio em uma escola pública localizada em Bragança-PA. Este estudo foi aplicado em duas fases, a primeira consistindo em uma pequena aula com correção de questões extraídas do livro didático, e a segunda consistindo em utilizar questões similares à da primeira fase onde os alunos contaram com ajuda do aplicativo “Física Interativa”. Posteriormente, os dados foram analisados, indicando que o aplicativo “Física Interativa” auxilia no processo de ensino e aprendizagem do ensino de Física em escolas públicas do Pará. Os resultados permitem apontar que o uso do aplicativo em sala de aula no ensino de Física altera drasticamente o nível de resolução das atividades pelos alunos. E, da mesma forma, demonstra que a facilidade e a melhoria do processo ensino e aprendizagem é largamente impactado pela utilização do aplicativo no ato de resolver as questões, indicando maior estímulo em aprender, dinamicidade no processo e significância dos conteúdos.
PERAN PROFESI NOTARIS DALAM MENJAGA KEWIBAWAAN NEGARA HUKUM INDONESIA
Authors: Primudyastutie Mirin , Sulistyono Anang
Published: June 2021

Eksistensi norma yuridis merupakan norma yang mengatur tentang peran yang bisa dilakukan oleh subyek hukum atau pihak yang ditunjukknya, diantaranya notaris. Norma yuridis yang menjadi pijakan utama bagi notaris diantaranya untuk menjalankan kewajiban-kewajiban atau kewenangan-kewenangannya. Peran mengimplementasikan norma yuridis ini adalah berkaitan  dengan tugas, kewajiban, kewenangan, larangan, dan lain sebagainya yang menentukan terhadap bekerjanya hukum, sehingga yang dilakukannya ini mengandung konsekuensi yuridis, yakni kewibawaan negara hukum. Ada hak-hak masyarakat dan martabat negara yang ikut dirugikan ketika norma hukum tidak dijalankan sebagaimana yang sudah digariskannya.  Kewibawaan negara hukum merupakan ujian riil propfesionalitas sebagai notaris, sehingga Ketika peran yang ditunjukkan tidak profesionalitas, dampak seriusnya terhadap kewibawaan negara hukum.Kata Kunci: kewibawaan, notaris, peran, negara The existence of juridical norms is a norm that regulates the roles that can be performed by a legal subject or party appointed by it, including a notary. Juridical norms that become the main foothold for notaries include to carry out their obligations or authorities. The role of implementing this juridical norm is related to the duties, obligations, authorities, prohibitions, etc. that determine the operation of the law, so that what it does has juridical consequences, namely the authority of the rule of law. There are community rights and state dignity that are also harmed when legal norms are not implemented as outlined by them. The authority of a rule of law is a real test of professionalism as a notary, so that when the role shown is not professional, it has a serious impact on the authority of the rule of law.Keywords: authority, notary, role, state
TINDAK PIDANA PEMBUNUHAN DENGAN CARA MEMOTONG-MOTONG MAYAT KORBAN DALAM PERSPEKTIF HUKUM DAN KRIMINOLOGI
Authors: Widyatmoko Bagus
Published: June 2021

Tindakan krimininalitas tidak hanya mengganggu ketentraman dan kenyaman terhadap kehidupan berbangsa dan bernegera, tetapi lebih dari itu kejahatan juga dapat menimbulkan kegelisahan dan rasa ketakutan yang lebih terhadap masyarakat secara umum. Terlebih dalam belakangan ini kasus-kasus kehajatan terus terjadi dan banyak mengalami peningkatan baik dari segi jumlah kasus ataupun dari jenis tindak pidana yang dilakukan oleh para pelaku, salah satunya adalah kasus pembunuhan yang disertai dengan memutilasi mayat korban hal ini tentu tergolong dalam kejahatan yang sangat sadis dan tidak manusiawi. Memutilasi mayat korban pembunuhan tentunya berbeda dengan pembunuhan biasa sehingga dalam penelitian ini dikemukakan bahwa pelaku mutilasi rata-rata dilatarbelakangi oleh karakter atau sifat bawaan manusia yang masuk dalam ketegori psikopat. Dengan demikian dari hasil penelitian ini diharapkan para pelaku dapat disadarkan sebelum melakukan tindak pidana pembunuhan yang disertai dengan mutilasi dengan cara memberikan penjatuhan pidana yang berat terhadap pelaku tindak pidana pembunuhan yang disertai dengan memutilasi mayat korban.Kata kunci: Tindak Pidana, Mutilasi, Hukum dan Kriminologi. Acts of criminality not only disturb peace and comfort in the life of the nation and haste, but more than that crime can also cause more anxiety and fear of society in general. Especially in recent times cases of corruption have continued to occur and have experienced an increase in both the number of cases and the types of criminal acts committed by the perpetrators, one of which is a murder case accompanied by mutilating the victim's corpse, this is certainly a very sadistic crime. and inhuman. Mutilating the corpse of a murder victim is certainly different from ordinary murder so that in this study it is argued that the perpetrators of mutilation are on average motivated by human characters or traits that fall into the category of psychopaths. Thus, from the results of this study, it is hoped that the perpetrators can be made aware of before committing the crime of murder which is accompanied by mutilation by giving the imposition of a serious punishment against the perpetrator of the crime of murder accompanied by mutilating the body of the victim.Keywords: Crime, Mutilation, Law and Criminology
IMPLEMENTASI PEMBAGIAN HARTA BERSAMA DALAM PERKAWINAN POLIGAMI
Authors: Fanani Zainul
Published: June 2021

Abstrak Pasal 94 ayat (1) kompilasi Hukum Islam menyebutkan harta bersama dari perkawinan seorang suami yang mempunyai istri lebih dari seorang, masing-masing terpisah dan berdiri sendiri, ayat (2) menyebutkan pemilikan harta bersama dari perkawinan seorang suami yang mempunyai isteri lebih dari seorang dihitung pada saat berlangsungnya akad perkawinan yang kedua, ketiga dan keempat. Dengan demikian momentum pelaksanaan perkawinan merupakan hal yang sangat signifikan dalam penentuan harta bersama dalam perkawinan poligami. Hal ini akan menjadi hambatan dalam pembagian harta bersama, khususnya menyangkut masalah pembuktian harta bersama tersebutKata kunci:  harta Bersama, poligami, pembagian Abstract Article 94 paragraph (1) compilation of Islamic law mentions joint property of marriage of more than one spouse, separate and independent, paragraph (2) mentions the joint ownership of marriage of husband of more than one spouse at the time of the second, third and fourth marriages. Thus the momentum of the marriage exercise is a very important factor in the determination of common property in polygamous marriage. This would be a hindrance in the sharing of common property, especially with regard to the issue of proof of the common propertyKeywords: Shared property, polygamy, subdivision
PELAKSANAAN PUTUSAN PERCERAIAN ATAS NAFKAH ISTRI DAN ANAK DI PENGADILAN AGAMA
Authors: Faizin Ahmad Nur
Published: June 2021

Dalam putusan mengenai pelaksanaan nafkah iddah, mut’ah serta nafkah untuk anak, eksekusi riil dilaksanakan oleh para pihak secara sukarela, atau oleh pengadilan melalui juru sita pengadilan setelah ada permohonan apabila salah satu pihak tidak bersedia melaksanakan putusan tersebut secara sukarela. Pengadilan tidak akan melaksanakan eksekusi apabila tidak ada permohonan eksekusi dari yang dirugikan. Untuk itu apabila permohonan eksekusi dilakukan maka terlebih dahulu mantan suami akan diberikan teguran agar memenuhi kewajibannya atas putusan pengadilan yang berkaitan dengan pemberian nafkah.Kata kunci: nafkah, perceraian, perkawinan, putusan pengadilan In the decision regarding the implementation of the iddah, mut'ah and maintenance for the child, the real execution is either voluntary, or by the court through the court's arbitrator upon application if either party is not willing to execute the decision voluntarily. The court will not execute the execution if there is no application for the execution of the damages. Therefore, if the execution of the application is made then the ex-husband will be reprimanded for fulfilling his duty on the court's decision relating to the provision of maintenance. Keywords: alimony, divorce, marriage, court decision
PERAN KPK DENGAN KEJAKSAAN DALAM PENANGGULANGAN TINDAK PIDANA KORUPSI DI INDONESIA
Authors: Zaini Agus
Published: June 2021

Kejaksaan dan Komisi Pemberantasan Korupsi (KPK) mempunyai peran strategis dalam penanggulangan korupsi. Tindak pidana Korupsi di Indonesia sudah meluas di masyarakat. Perkembangannya pun terus meningkat dari tahun ke tahun, baik dari jumlah kasus yang terjadi maupun jumlah kerugian keuangan negara. Kualitas tindak pidana korupsi yang dilakukan juga semakin sistematis dengan lingkup yang memasuki seluruh aspek kehidupan masyarakat. Kondisi tersebut menjadi salah satu faktor utama penghambat keberhasilan untuk mewujudkan masyarakat Indonesia yang adil dan makmur sebagaimana diamanatkan oleh Undang-Undang Dasar Negara Republik Indonesia Tahun 1945.Kata Kunci: Kejaksaan, korupsi, penanggulangan, hukum The Prosecutors' Office and the Corruption Eradication Commission (KPK) have a strategic role in tackling corruption. Corruption in Indonesia has become widespread. Its development continues to increase from year to year, both from the number of cases that occur and the amount of state financial losses. The quality of corruption committed is also more systematic with a scope that enters all aspects of people's lives. This condition is one of the main factors hampering success in realizing a just and prosperous Indonesian society as mandated by the 1945 Constitution of the Republic of Indonesia.Keywords: Prosecutors, corruption, countermeasures, law
Human Rights Education Potential "Preparing Students In Cultural Diversity Context"
Authors: Mustofa Muhammad Khairil
Published: June 2021

Human rights education is indispensable in preparing students who live in the context of a multicultural society. Human rights education has great potential to make a fundamental contribution in imparting the principles of democracy and human rights for students. However, the school environment where human rights education is implemented has its own problems and challenges that have the potential to hinder the implementation of human rights education. So it requires a strong commitment from schools to maximize the potential of human rights education by creating a school environment that is conducive to the implementation of democratic principles on the basis of human rights.Keywords: human rights, democracy, participation.
Persepsi Pengunjung Tentang Objek Wisata Di Taman Wisata Alam Sorong Provinsi Papua Barat
Authors: Pattiwael Maya , Serkadifat Yetty Siska
Published: June 2021

AbstrakSuatu kawasan yang dijadikan sebagai tempat wisata tentu harus memiliki daya tarik tersendiri yang unik dan berbeda dengan kawasan wisata lainnya. TWA Sorong merupakan salah satu kawasan wisata yang masih terus dikembangkan untuk menarik minat wisatawan atau pengunjung untuk datang ke tempat tersebut. Peningkatan jumlah pengunjung di suatu lokasi juga tidak terlepas dari kepuasan pengunjung itu sendiri terhadap daerah yang dikunjungi. Pemilihan responden sebagai sampel penelitian dilakukan dengan metode Accidental Sampling. Sampel dalam penelitian ini adalah sebanyak 67 orang. Pengumpulan data pada penelitian ini dilakukan dengan cara studi kepustakaan, observasi langsung di lapangan, serta pembagian kuesioner kepada pengunjung objek wisata di Taman Wisata Alam Sorong. Persepsi pengunjung tentang objek wisata di Taman Wisata Alam Sorong memberikan hasil yang positif untuk 4 indikator yaitu daya tarik (skor rata-rata 285,2 dengan kategori sangat baik), aksesibilitas (Skor rata-rata 260, kategori baik), fasilitas (Skor rata-rata 264,9 kategori baik) dan layanan tambahan (Skor rata-rata 241,5 dengan kategori baik) . Beberapa harapan yang disampaikan oleh responden terkait pengembangan lokasi tersebut ke depan yaitu berupa perbaikan fasilitas yang ada seperti penambahan tempat sampah dan adanya kebersihan toilet.
Strategi Pengembangan Agroforestri Dusung Di Negeri Hative Besar Kecamatan Teluk Ambon Kota Ambon
Authors: Maipauw Niny Jeni , Silaya M , Loppies R
Published: June 2021

Agroforestry adalah pendekatan terintegrasi memanfaatkan interaksi pohon dan belukar dengan tanaman pertanian dan atau peternakan. Agroforestry menggabungkan teknologi pertanian dan kehutanan untuk menciptakan kondisi yang lebih beranekaragam, produktif, sehat, menguntungkan dan system penggunaan lahan yang lestari. Penelitian ini bertujuan untuk mengetahui factor-faktor apa saja yang mempengaruhi pengembangan agroforestry dan strategi pengembangan di Negeri Hative Besar, Kecamatan Teluk Ambon Kota Ambon. Metode penelitian ini adalah metode survey dan wawancara. Data yang diperoleh melalui pengamatan langsung dan quisioner. Metode analisa adalah kuantitatif dan kualitatif. Hasil penelitian menunjukkan faktor-faktor yang mempengaruhi pengembangan agroforestry dusung adalah vegetasi pohon, tanaman pangan, tanaman tahunan, sosial ekonomi petani, pengelolaan lahan tradisional yang disebut dusung. Penerapan dan pengembangan agroforestry dilakukan melalui analisa SWOT
Kajian Karakteristik Morfometri Daerah Aliran Sungai Klawoguk Kota Sorong Berbasis Sistem Informasi Geografis
Authors: Farida Anif , Irnawati Irnawati
Published: June 2021

DAS Klawoguk yang masuk dalam wilayah Kota Sorong mempunyai permasalahan yang selalu berulang yaitu banjir. Hampir setiap ada hujan yang jatuh dengan intensitas yang cukup tinggi akan mengakibatkan banjir di beberapa lokasi yang dekat dengan sungai. Tujuan penelitian ini untuk mengidentifikasi karakteristik morfometri DAS Klawoguk dengan menggunakan Sistem Informasi Geografis (SIG). Parameter morfometri yang dihitung adalah luas DAS, panjang sungai utama, kemiringan sungai utama, bifurcation ratio, form factor, circularity ratio, drainage density, texture ratio dan length of overland flow. Analisis spasial dilakukan dengan bantuan software MapInfo Professional 11.5 sedangkan analisis dekripstif kualitatif Â dilakukan dengan cara mengkaji hasil perhitungan morfometri DAS. Hasil penelitian menunjukkan bahwa luas DAS Klawoguk 31,26 km2 dengan panjang sungai utama 20,61 km dan kemiringan sungai utama 0,01 (1 %). Nilai Rb (bifurcation ratio) sebesar 13,68, form factor sebesar 0,020 yang berarti bentuk DAS tidak bulat dan circularity ratio (Rc) 0,25 termasuk dalam kategori bentuk DAS memanjang. Kerapatan drainase 3,52 km/km2 masuk dalam kelas sedang, nilai texture ratio 3,87 dan nilai length of overland flow sebesar 1,76. Berdasarkan parameter morfometri tersebut DAS Klawoguk mempunyai kenaikan debit banjir yang cepat dengan air tidak tergenang terlalu lama, volume runoff yang dihasilkan juga cukup besar, kemampuan infiltrasi yang rendah dan durasi waktu yang diperlukan oleh aliran untuk mencapai outlet tidak terlalu cepat.
Potensi Ekowisata Hutan Mangrove Klawalu Kota Sorong Papua Barat
Authors: Naa Lusye , Wanggai Charly B. , Siburian Rima Herlina
Published: June 2021

Klawalu merupakan salah satu daerah di Kota Sorong yang memiliki potensi mangrove yang masih terjaga secara alami. Sejalan dengan pengembangan pembangunan maka ekowisata merupakan alternatif yang perlu dipertimbangkan dalam menjaga ekosistim kawasan dengan tetap meningkatkan ekonomi masyarakat sekitar. Tujuan penelitian ini adalah untuk mengetahui potensi ekowisata hutan mangrove Klawalu Kota Sorong. Metode yang digunakan adalah metode deskritif dengan teknik observasi lapangan dan wawancara berpedoman pada analisis ADO-ODTWA Dirjen PHKA Tahun 2003. Hasil penelitian menunjukkan bahwa nilai kriteria obyek dan daya tarik kawasan memiliki nilai tertinggi dengan total skor 960. Hal ini menunjukkan bahwa kawasan ekowisata mangrove Klawalu memiliki tingkat keunikan yang didukung oleh floran dan fauna penyusunannya dengan aksesisibilitas serta sarana dan prasarana penunjang serta ketersediaan air bersih yang dapat digunakan sebagai daerah pengembangan ekowisata yang sangat baik. Dari unsurur penilaian yang dilakukan baik terhadap aksesibilitas, kondisi lingkungan sekitar kawasan, maupun ketersediaan air bersih menunjukkan bahwa kawasan ini siap untuk menjadi destinasi wisata yang dapat dikembangkan.
Pertumbuhan Stek Batang Tumbuhan Obat Tali Kuning (Tinospora dissitiflora Diels) Pada Media Tanah Dan Pasir
Authors: Taam Yohanes , Tampang Ana , Wahyudi Wahyudi
Published: June 2021

Tali kuning (Tinospora dissitifloraÂ Diels) is medicinal plant endemic to New Guinea, widely used to prevent and cure malaria symptoms in Papua. In utilizing this plant, they harvest directly from the forest without planting. If this continue, it will become extinct. This research, therefore, is to investigate responds of cutting stem of Tali kuning planted on four media, soil, sand, and forest litter and their combinations. Variables consist of growing cuttings, callus cuttings, shoots cuttings, rooted cuttings and express in percent. The cuttings produce callus, shoots, and leaf are expressed in days. Numbers of leaf, roots, and tendrils (shoots enlengthen) are counted in sheets. Length of tendrils and roots are measured in cm. The results indicate that Tali kuning can be planted using cutting stem in the media tested. Soil media resulted the highest percentage of growing cuttings, callus, shoots, and rooted. Callus is produced at 16 days at average, shoots at 21 days, and leaf at 26 days. Each media produces a single tendril at average 27.44 cm in length, 15 roots with 5.84 cm long, and leaf of 8 sheets. Tukey test indicates that four planting media did not result significantly different for growth variable, except for the length of roots.Key words:Â Growth, cutting stem, Tali kuning, planting media
Persepsi Masyarakat Terhadap Pengelolaan Lingkungan Di Kelurahan Amban Kabupaten Manokwari
Authors: Tanati Agustina A , Siburian Rima Herlina , Murdjoko Agustinus A
Published: June 2021

Pengelolaan lingkungan pada kelurahan Amban merupakan suatu hal yang menarik karena kawasan ini merupakan salah satu kawasan padat penduduk di Kabupaten Manokwari. Tujuan penelitian ini adalah untuk mengetahui bagaimana persepsi masyarakat terhadap pengelolan lingkungan pada kawasan ini. Metode yang digunakan dalam penelitian ini adalah metode survei dengan metode deskriptif dengan pembagian kasus atas enam kategori penilaian, dan didukung oleh data sekunder. Hasil penelitian menunjukkan bahwa sebagian besar masyarakat yang berada pada kelurahan Amban sangat setuju terhadap pola perencanaan pemanfaatan, pengendalian, pemeliharaan, pengawasan serta penegakan hukum yang dilakukan pada wilayah ini. Data ini diperoleh dari tiga wilayah yang tersebar pada wilayah Kelurahan Amban Manokwari. Â Â
Partisipasi Masyarakat Terhadap Tanaman Pala (Myristica fragrans) Di Kampung Kamandur Tetar Distrik Wartutin Kabupaten Fakfak
Authors: Wattimena Lanny , Serkadifat Yetti , Kabes Terry
Published: June 2021

Hutan merupakan sumber kekayaan alam dan sumber penyangga bagi kehidupan. Hutan dapat menghasilkan hasil hutan kayu dan hasil hutan non kayu. Pala merupakan salah satu hasil hutan hasil hutan non kayu yang memiliki nilai ekonomis tinggi. Oleh sebab itu dibutuhkan partisipasi dari berbagai kalangan baik masyarakat kampung maupun pemerintah melalui dinas terkait.Penelitian ini bertujuan untuk mengetahui bentuk-bentuk partisipasi masyarakat terhadap tanaman pala (Myristica fragrans) di Kampung Kamandur Tetar Distrik Wartutin Kabupaten Fak-fak, serta mengetahui faktor-faktor yang mempengaruhi partisipasi masyarakat terhadap tanaman pala.Kampung Kamandur Tetar Distrik Wartutin Kabupaten Fak-fak merupakan lokasi penelitian, yang dilaksanakan pada bulan Agustus 2020. Objek yang diteliti tentang partisipasi masyarakat terhadap tanaman pala (Myristica fragrans). Metode wawancara dan observasi digunakan untuk pengumpulan data. Data yang diperoleh, dianalisis secara deskriptif, dan ditampilkan melalui tabel dan gambar. Hasil penelitian menunjukan bahwa Masyarakat Kampung Kamandur Tetar berpartisipasi aktif dalam setiap kegiatan yang berkaitan dengan pelestarian dan pengolahan tanaman pala. Partisipasi dilaksanakan dalam bentuk perencanaan, pelaksanaan, dan pengendalian kegiatan, serta pemanfaatan hasil. Faktor-faktor yang mempengaruhi partisipasi masyarakat terhadap tanaman pala adalah jenis kelamin, tingkat umur, tingkat pendidikan, jenis pekerjaan, dan lama tinggal.
Pengaruh Karakteristik Responden dengan Keterampilan Petani dalam Mengolah Limbah Hasil Pertanian di Kampung Majener Kabupaten Sorong
Authors: Rosalina Febrianti , Maipauw Niny Jeni
Published: June 2021

Penelitian ini bertujuan untuk mengetahui hubungan antar karakteristik petani dengan keterampilannya dalam mengolah limbah hasil pertanian dalam meningkatkan kesuburan tanah khususnya pada masyarakat petani di Kampung Majener, Kabupaten Sorong. Jenis penelitian adalah penelitian survei dengan menggunakan pendekatan kuantitatif. pengumpulan data yang digunakan yaitu observasi, wawancara, survei dan dokumentasi. Data hasil penelitian kemudian diolah dan dianalisis dengan menggunakan statistik deskriptif dan regresi linier berganda. Hasil penelitian menunjukkan bahwa aspek keterampilan dengan jenjang Pendidikan terakhir memiliki tingkat keterhubungan yang siginifikan sebesar 0,085 dengan korelasi sebesar 0,320 dibandingkan dengan 3 aspek lainnya, hal ini memperlihatkan bahwa penguasaan keterampilan oleh petani menjadi sebuah hal yang sangat menunjang kemampuan petani dalam mengolah limbah hasil pertanian secara mandiri yang dilandasi oleh tingkat/jenjang Pendidikan terakhir dari petani itu. Artinya keberhasilan petani dalam mengolah limbah hasil pertanian ditunjang oleh jenjang Pendidikan yang baik pula dan dapat berdampak pada kesejahteraan para petani dimasa yang akan datang.
Pengembangan Home Industri Bawang Merah Goreng Di Kelurahan Mlatiharo Kecamatan Semarang Timur
Authors: Rinawati Tri , Meiriyanti Rita , Yani Tri Endang
Published: June 2021

Masyarakat sebenarnya memiliki banyak potensi baik dilihat dari sumber sumber daya alam maupun dari sumber sosial budayanya. Masyarakat memiliki kekuatan yang bila digali dan disalurkan akan menjadi energi yang besar untuk membangun. Didalam pemberdayaan masyarakat yang penting adalah bagaimana menduduki masyarakat pada posisi pelaku pembangunan yang aktif, bukan penerima pasif, konsep gerakan pemberdayaan masyarakat mengutamakan inisiatif dan kreasi masyarakat dengan strategi pokok pemberian kekuatan kepada masyarakat. Masyarakat harus diberdayakan agar masyarakat mampu mengenali kebutuhan-kebutuhannya, merumuskan rencana-rencananya serta melaksanakan pembangunan secara mandiri dan swadaya. Permasalahan utama pengusaha industri rumahan produk bawang merah goreng di wilayah Kelurahan Mlatiharjo Kecamatan Semarang Timur ini tentang kualitas produk yang belum maksimal, kurangnya pemahaman tentang aspek pasar dan pemasaran.Kegiatan pengabdian ini dilakukan dengan pendekatan penyuluhan, pelatihan dan pendampingan para pelaku usaha industri rumahan di wilayah Kelurahan Mlatiharjo Kecamatan Semarang Timur, evaluasi hasil, serta metode sharing sebagai media pemecahan masalah. PelaksanaanÂ  kegiatan PengabdianÂ  Kepada MasyarakatÂ  di Kelurahan Mlatiharjo Kecamatan Semarang Timur telah terlaksana. Kegiatan yang dilakukan yaitu memberikan pemahaman tentang pentingnya perbaikan kualitas produk, aspek pasar dan pemasaran melalui kegiatan penyuluhan; melakukan diskusi mengenai kegiatan pengabdian tentang hal-hal yang terkait dengan kualitas produk, aspek pasar dan pemasaran; melatih cara menggunakan alat perajang baik manual maupun mesin serta cara menggunakan mesin spinner atau mesin peniris; kegiatan pendampingan melakukan proses produksi, penggunaan alat, pengemasan dan pelabelan; kegiatan evaluasi setelah kegiatan pengabdian.
Study of Susceptibility of Staphylococcosis and Streptococcosis Causative Agents to Medicinal Preparations
Authors: Abbasov S.
Published: June 2021

The article gives consideration to the determination of the susceptibility of causative agents of staphylococcosis and streptococcosis to antibiotics. Long-term use of medicinal preparations, including antibiotics, leads to the emergence of generations of microorganisms that are resistant to causative agents of infectious diseases, and this is the reason for the decrease in the effectiveness of medical and preventive measures. Considering all this, the susceptibility degree of cultures of causative agents of staphylococcosis and streptococcosis to drugs such as enroline, colistin, gentamicin, tilazine, furazalidone and neomycin was studied. The susceptibility of Staphylococcus pyugenes cultures to enroline, gentamicin and colistin by 22.2%, and to furasilidone by 74.0%, and Streptococcus feccalus cultures by 38.0% to enolin, by 33.3% to gentamicin, by 19.0% to colistin and by 33.3% to furazalidone were investigated. On the basis of findings of investigations, the highest sensitivity of Staphylococcus pyugenes to furazalidone by 74.0% was revealed. And from the preparations we studied, it was found that Streptococcus feccalus is susceptible to enroline by 38.0%.
Didaktisk modell som stöd för en fyllig behandling av det komplexa riskbegreppet
Authors: Sjöström Jesper
Published: June 2021

Många forskare menar att vårt samhälle kan betecknas som ett risksamhälle. Frågor om risk kopplar till flera olika skolämnen och inte minst till de naturvetenskapliga. En ny forskningsartikel presenterar en didaktisk modell som visar på riskbegreppets komplexitet och som hjälper lärare att behandla det på ett fylligt och mångsidigt sätt i sin undervisning.
Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
Authors: Wan Junlin , Jiang Jun , Li Juan
Published: June 2021

An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy.
Photodynamic Therapy—Current Limitations and Novel Approaches
Authors: Gunaydin Gurcan , Gedik M. Emre , Ayan Seylan
Published: June 2021

Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be applied in the settings of several malignant diseases. In fact, the earliest preclinical applications date back to 1900’s. Dougherty reported the treatment of skin tumors by PDT in 1978. Several further studies around 1980 demonstrated the effectiveness of PDT. Thus, the technique has attracted the attention of numerous researchers since then. Hematoporphyrin derivative received the FDA approval as a clinical application of PDT in 1995. We have indeed witnessed a considerable progress in the field over the last century. Given the fact that PDT has a favorable adverse event profile and can enhance anti-tumor immune responses as well as demonstrating minimally invasive characteristics, it is disappointing that PDT is not broadly utilized in the clinical setting for the treatment of malignant and/or non-malignant diseases. Several issues still hinder the development of PDT, such as those related with light, tissue oxygenation and inherent properties of the photosensitizers. Various photosensitizers have been designed/synthesized in order to overcome the limitations. In this Review, we provide a general overview of the mechanisms of action in terms of PDT in cancer, including the effects on immune system and vasculature as well as mechanisms related with tumor cell destruction. We will also briefly mention the application of PDT for non-malignant diseases. The current limitations of PDT utilization in cancer will be reviewed, since identifying problems associated with design/synthesis of photosensitizers as well as application of light and tissue oxygenation might pave the way for more effective PDT approaches. Furthermore, novel promising approaches to improve outcome in PDT such as selectivity, bioengineering, subcellular/organelle targeting, etc. will also be discussed in detail, since the potential of pioneering and exceptional approaches that aim to overcome the limitations and reveal the full potential of PDT in terms of clinical translation are undoubtedly exciting. A better understanding of novel concepts in the field (e.g.enhanced, two-stage, fractional PDT) will most likely prove to be very useful for pursuing and improving effective PDT strategies.
Proteomics Analysis of the Spinal Dorsal Horn in Diabetic Painful Neuropathy Rats With Electroacupuncture Treatment
Authors: Yu Xiangmei , Chen Xiaomei , Liu Weiting , Jiang Menghong , Wang Zhifu , Tao Jing
Published: June 2021

Background

Clinical evidence demonstrates that electro-acupuncture (EA) of the Zu sanli (ST36) and Shen shu (BL23) acupoints is effective in relieving diabetic painful neuropathy (DPN); however, the underlying molecular mechanism requires further investigation, including the protein molecules associated with EA’s effects on DPN.

Methods

Sprague-Dawley adult male rats (n =36) were randomly assigned into control, DPN, and EA groups (n=12 each). After four weeks of EA treatment, response to mechanical pain and fasting blood glucose were analyzed. A tandem mass tag (TMT) labeling approach coupled with liquid chromatography with tandem mass spectrometry was used to identify potential biomarkers in the spinal dorsal horn. Further, proteomics analysis was used to quantify differentially expressed proteins (DEPs), and gene ontology, KEGG pathways, cluster, and string protein network interaction analyses conducted to explore the main protein targets of EA.

Results

Compared with the DPN model group, the mechanical pain threshold was significantly increased, while the fasting blood glucose levels were clearly decreased in EA group rats. Proteomics analysis was used to quantify 5393 proteins, and DEPs were chosen for further analyses, based on a threshold of 1.2-fold difference in expression level (P < 0.05) compared with control groups. Relative to the control group, 169 down-regulated and 474 up-regulated proteins were identified in the DPN group, while 107 and 328 proteins were up- and down-regulated in the EA treatment group compared with the DPN group. Bioinformatics analysis suggested that levels of proteins involved in oxidative stress injury regulation were dramatically altered during the EA effects on DPN.

Conclusions

Our results provide the valuable protein biomarkers, which facilitates unique mechanistic insights into the DPN pathogenesis and EA analgesic, antioxidant stress and hypoglycemic effect.
Serum Progesterone Profile Across the Mid and Late Luteal Phase in Artificial Cycles Is Associated With Pregnancy Outcome
Authors: Labarta Elena , Rodríguez-Varela Cristina , Mariani Giulia , Bosch Ernesto
Published: June 2021

Introduction

Recent studies have shown that low serum progesterone levels on the day of embryo transfer (ET) are associated with poorer pregnancy outcome in hormonal replacement therapy cycles. It is of interest to know if serum progesterone levels during late luteal phase (following days after ET) are also related with the chances of ongoing pregnancy.

Objective

To evaluate the luteal phase endocrine profile through measurements of serum progesterone and estradiol on days ET+4, ET+7 and ET+11, to test their predictive value in relation to pregnancy outcome.

Setting

Private infertility center, Valencia, Spain.

Materials and Methods

Prospective cohort study performed between June 2017 and August 2018. Eligible patients were aged between 18-42 years, with a normal uterus, and being transferred 1-2 good quality blastocysts in a frozen ET cycle after an artificial endometrial preparation with estradiol valerate and vaginal micronized progesterone (400 mg/12 hours).

Results

A total of 127 patients were included. Mean age = 38.0 ± 3.9 years; BMI = 23.6 ± 3.6 kg/m2; endometrial thickness = 9.1 ± 1.6mm. Overall ongoing pregnancy rate = 47.2% (95%CI:38.3-56.3). Significantly higher levels of serum progesterone were observed on ET+4 (13.6 ± 6.0 vs. 11.1 ± 4.6ng/ml, p = 0.03) and ET+11 (15.7 ± 1.2 vs. 10.3 ± 0.6ng/ml, respectively; p = 0.000) in ongoing pregnancies versus negative β-hCG (β-human chorionic gonadotrophin) cases. On ET+7, ongoing pregnancies also had higher serum progesterone levels (14.2 ± 0.9 vs. 11.7 ± 0.8ng/ml, but did not reach statistical significance (p = 0.07). Serum estradiol levels were not related with pregnancy outcome at any moment of the luteal phase (p > 0.05). On days ET+4, +7 and +11, the ROC analysis showed that serum progesterone levels were predictive of ongoing pregnancy, and Pearson’s coefficient showed a significant association (p<0.05) of serum β-hCG levels with serum progesterone.

Conclusions

In hormonal replacement therapy cycles, serum progesterone levels across luteal phase days are associated with pregnancy outcome. Ongoing pregnancies were associated with a higher exposure to progesterone in comparison with pregnancy losses or negative β-hCG. Therefore, serum progesterone might be playing an important role not only during implantation, but also in pregnancy maintenance. It remains unknown if the variability in serum progesterone levels among patients, after receiving the exact same progesterone dose for luteal phase support, is the cause or just a consequence of pregnancy results.
Nitrogen Dioxide, Greenhouse Gas Emissions and Transportation in Urban Areas: Lessons From the Covid-19 Pandemic
Authors: Restrepo Carlos E.
Published: June 2021

Nitrogen dioxide (NO2) is a pollutant of concern in urban areas around the world. The main sources in urban environments are related to the burning of fuel and include transportation, electricity generation, and industrial and residential activities. From a public health perspective NO2 has also been widely associated with respiratory disease, including asthma exacerbation. NO2 also plays a key role in ground-level concentrations of ozone (O3), which is also a public health concern. This policy brief explores the relationships between transportation, climate change mitigation and ambient levels of air pollutants such as NO2. The Covid-19 pandemic has offered a glimpse of how rapid changes in transportation use can result in significant decreases in NO2 concentrations. Data from New York City supports this relationship. Transportation policies aimed at reducing traffic offer an opportunity to both mitigate greenhouse gas emissions and improve air quality. The implementation of measures to rethink public space and the use of streets in response to Covid-19 also provides insights into an additional policy alternative to achieve these goals.
Development and Exploitation of KASP Assays for Genes Underpinning Drought Tolerance Among Wheat Cultivars From Pakistan
Authors: Ur Rehman Shoaib , Ali Sher Muhammad , Saddique Muhammad Abu Bakar , Ali Zulfiqar , Khan Mahmood Alam , Mao Xinguo , Irshad Ahsan , Sajjad Muhammad , Ikram Rao Muhammad , Naeem Mahnoor , Jing Ruilian
Published: June 2021

High-throughput genotyping for functional markers offers an excellent opportunity to effectively practice marker-assisted selection (MAS) while breeding cultivars. We developed kompetitive allele-specific PCR (KASP) assays for genes conferring drought tolerance in common wheat (Triticum aestivum L.). In total, 11 KASP assays developed in this study and five already reported assays were used for their application in wheat breeding. We investigated alleles at 16 loci associated with drought tolerance among 153 Pakistani hexaploid wheat cultivars released during 1953–2016; 28 diploid wheat accessions (16 for AA and 12 for BB) and 19 tetraploid wheat (AABB) were used to study the evolutionary history of the studied genes. Superior allelic variations of the studied genes were significantly associated with higher grain yield. Favored haplotypes of TaSnRK2.3-1A, TaSnRK2.3-1B, TaSnRK2.9-5A, TaSAP-7B, and TaLTPs-1A predominated in Pakistani wheat germplasm indicating unconscious pyramiding and selection pressure on favorable haplotypes during selection breeding. TaSnRK2.8-5A, TaDreb-B1, 1-feh w3, TaPPH-7A, TaMOC-7A, and TaPARG-2A had moderate to low frequencies of favorable haplotype among Pakistani wheat germplasm pointing toward introgression of favorable haplotypes by deploying functional markers in marker-assisted breeding. The KASP assays were compared with gel-based markers for reliability and phenotypically validated among 62 Pakistani wheat cultivars. Association analyses showed that the favorable allelic variations were significantly associated with grain yield-contributing traits. The developed molecular marker toolkit of the genes can be instrumental for the wheat breeding in Pakistan.
Transcriptional and Microenvironmental Landscape of Macrophage Transition in Cancer: A Boolean Analysis
Authors: Avila-Ponce de León Ugo , Vázquez-Jiménez Aarón , Matadamas-Guzman Meztli , Pelayo Rosana , Resendis-Antonio Osbaldo
Published: June 2021

The balance between pro- and anti-inflammatory immune system responses is crucial to face and counteract complex diseases such as cancer. Macrophages are an essential population that contributes to this balance in collusion with the local tumor microenvironment. Cancer cells evade the attack of macrophages by liberating cytokines and enhancing the transition to the M2 phenotype with pro-tumoral functions. Despite this pernicious effect on immune systems, the M1 phenotype still exists in the environment and can eliminate tumor cells by liberating cytokines that recruit and activate the cytotoxic actions of TH1 effector cells. Here, we used a Boolean modeling approach to understand how the tumor microenvironment shapes macrophage behavior to enhance pro-tumoral functions. Our network reconstruction integrates experimental data and public information that let us study the polarization from monocytes to M1, M2a, M2b, M2c, and M2d subphenotypes. To analyze the dynamics of our model, we modeled macrophage polarization in different conditions and perturbations. Notably, our study identified new hybrid cell populations, undescribed before. Based on the in vivo macrophage behavior, we explained the hybrid macrophages’ role in the tumor microenvironment. The in silico model allowed us to postulate transcriptional factors that maintain the balance between macrophages with anti- and pro-tumoral functions. In our pursuit to maintain the balance of macrophage phenotypes to eliminate malignant tumor cells, we emulated a theoretical genetically modified macrophage by modifying the activation of NFκB and a loss of function in HIF1-α and discussed their phenotype implications. Overall, our theoretical approach is as a guide to design new experiments for unraveling the principles of the dual host-protective or -harmful antagonistic roles of transitional macrophages in tumor immunoediting and cancer cell fate decisions.
Pro-Resolving Ligands Orchestrate Phagocytosis
Authors: Decker Christa , Sadhu Sudeshna , Fredman Gabrielle
Published: June 2021

The resolution of inflammation is a tissue protective program that is governed by several factors including specialized pro-resolving mediators (SPMs), proteins, gasses and nucleotides. Pro-resolving mediators activate counterregulatory programs to quell inflammation and promote tissue repair in a manner that does not compromise host defense. Phagocytes like neutrophils and macrophages play key roles in the resolution of inflammation because of their ability to remove debris, microbes and dead cells through processes including phagocytosis and efferocytosis. Emerging evidence suggests that failed resolution of inflammation and defective phagocytosis or efferocytosis underpins several prevalent human diseases. Therefore, understanding factors and mechanisms associated with enhancing these processes is a critical need. SPMs enhance phagocytosis and efferocytosis and this review will highlight mechanisms associated with their actions.