bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Personal Branding terhadap Minat Beli Konsumen (Survei pada followers Social Media YouTube @GadgetIn)
Authors: Suprimansyah Reza , Yusuf Ramayani
Published: June 2023

Penelitian ini bertujuan untuk mengevaluasi pengaruh personal branding terhadap minat beli konsumen pada followers media sosial YouTube @GadgetIn.@GadgetIn adalah salah satu channel YouTube terkemuka di Indonesia yang fokus pada ulasan dan review gadget serta topik terkait teknologi. Metode survei digunakan untuk mengumpulkan data dari 100 responden yang merupakan mahasiswa/i Universitas Garut. Data dianalisis menggunakan teknik regresi linier sederhana dengan pendekatan kuantitatif diskriptif dengan bantuan software SPSS. Hasil penelitian menunjukkan bahwa personal branding yang terdiri dari citra personal, kepercayaan, dan kesetiaan berpengaruh positif dan signifikan terhadap minat beli. Implikasi dari penelitian ini adalah pentingnya personal branding dalam mempengaruhi perilaku konsumen terhadap minat beli konsumen dan pentingnya penerapan personal branding yang efektif bagi para influencer di media sosial.
HUBUNGAN PENGETAHUAN DAN SIKAP IBU DENGAN KEJADIAN STUNTING PADA BALITA DI DESA PARUNGSEHAH KECAMATAN SUKABUMI
Authors: Azmi Faizal , Alinda Alinda , Yusanti Ega , Alisa Meilia Siti , Nurul Sakinah Gina , Rosmala Ria , Lesmana Andi
Published: June 2023

Stunting merupakan masalah kekurangan gizi yang kronis yang terjadi pada saat periode kritis proses tumbuh kembang mulai janin. Masalah gizi ini mengacu pada kualitas kehidupan anak, dilihat dari tumbuh kembangnya yang tidak sesuai dengan kemampuan genetiknya. Terhambatnya pertumbuhan dan perkembangan balita di sebabkan stunting.Stunting adalah penyakit tumbuh kembang anak yang ditandai dengan rendahnya tinggi badan serta pada saat bertambahnya usia tubuh anak yang mengalami stunting tidak berkembang baik sesuai dengan usianya dan berlangsung dalam waktu lama. Stunting bisa dipicu oleh beberapa faktor di antaranya infeksi atau kekurangan gizi pada ibu hamil, kekurangan gizi pada saat bayi, dan stimulasi yang buruk dari lingkungan sekitar. Tujuan penelitian ini yaitu untuk memberikan binaan kepada masyarakat di desa Parungseah Kecamatan Sukabumi terkait pencegahan stunting yang terjadi pada balita dan di harapkan juga kepada orang tua untuk lebih menyadari sejak awal betapa pentingnya pengetahuan mengenai stunting. Disarankan juga kepada pihak tenaga kesehatan yang khususnya berada dilingkungan tersebut dapat memberikan pendidikan kesehatan untuk meningkatkan pengetahuan ibu mengenai stunting.
HUBUNGAN POLA ASUH ORANG TUA DENGAN KEMAMPUAN SOSIALISASI ANAK PRASEKOLAH
Authors: Julianti Hardiana , Jusmaeni Risnawati
Published: June 2023

Latar Belakang: Orang tua memiliki peranan penting dalam mengembangkan kemampuan sosialisasi anak, sebab orang tua merupakan sosok pertama dan utama dalam memberikan perlakuan terhadap anak yang diwujudkan dalam bentuk pola asuh. Tujuan: untuk mengetahui, menganalisis hubungan pola asuh orang tua dengan kemampuan sosialisasi anak di TK Islam Al- Hidayah Makassar. Metode: Desain penelitian deskriptif analitik dengan jenis penelitian cross sectional. Sampel pada penelitian ini adalah 35 orang anak termasuk orang tua dan siswa prasekolah yang memenuhi kriteria inklusi. Dan data didapatkan melalui kuesioner dan lembar observasi. Analisa data menggunakan uji Somer’s D.  Hasil: Hasil penelitian menunjukkan ada hubungan pola asuh orang tua dengan kemampuan sosialisasi anak prasekolah di TK Islam Al Hidayah Makassar dengan nilai (p = 0,022 < α  0,05 ). Kesimpulan: Kemampuan sosialisasi anak prasekolah dipengaruhi oleh gaya asuh orang tua.  Gaya asuh orang tua dengan demokratis dapat memfasilitasi kemampuan anak untuk bersosialisasi dibandingkan pola asuh orang tua dengan otoriter
De la política a la religión. Aspectos históricos y bibliográficos sobre los orígenes de la restauración antihegeliana, 1832-1844
Authors: Narváez León Angelo Antonio
Published: June 2023

In this work we’ll present a part of the debates that configured la indirect reception of the Hegelian philosophy through the second quarter of the XIX century. For this we’ll briefly describe the experience and path of the Verein in charge of the first edition of Hegel’s works; the, we’ll analyze the disputes over the hypothetical Hegelian republicanism; and, finally, we’ll focus on the interpretation that the Young Hegelians made of that same debate in the context of Schelling’s arrival at Berlin.

En este trabajo presentaremos una parte de los debates que configuraron la recepción indirecta de la filosofía hegeliana durante el segundo cuarto del siglo XIX. Para ello describiremos brevemente la experiencia y recorrido de la Verein a cargo de la primera edición de las obras de Hegel, luego, analizaremos las disputas en torno al hipotético republicanismo hegeliano y, finalmente, nos enfocaremos en la interpretación que los jóvenes hegelianos realizaron de esa misma disputa en el contexto de la llegada de Schelling a Berlín.
Gestación por sustitución: algunas cuestiones éticas en torno a la autonomía desde una visión transnacional
Authors: Barakat Molero Sara
Published: June 2023

Se reflexiona sobre la reprobabilidad moral de la Gestación por Sustitución a través del debate en torno a la autonomía de la gestante y los derechos reproductivos. En primer lugar, se contrastan las posturas liberal y feminista en países del Norte. Asimismo, se consideran las implicaciones para el debate de los intereses económicos de la industria de las Nuevas Técnicas de Reproducción Humana Asistida. Por último, se examina el fenómeno desde una perspectiva transnacional a través de un análisis interseccional y teniendo en cuenta los estudios etnográficos realizados por investigadoras en la India y sus implicaciones para el debate.
Teoría estética y feminismos: respuestas inclusivas y globales a la experiencia en el arte y la sociedad actual
Authors: Martínez-Collado Ana Luisa
Published: June 2023

El artículo analiza los procesos deconstructivos propuestos por la estética feminista desde la reivindicación de la experiencia y la defensa de un pluralismo interpretativo que reevalúe el proyecto moderno. Se revisan, de este modo, los conceptos de subjetividad, creatividad, genio, estética pura del placer y las categorías de lo bello y lo sublime para visibilizar perspectivas estéticas tradicionalmente silenciadas. Perspectivas necesariamente inclusivas que concilian la afirmación de la diferencia en un mundo global donde identidades, cuerpos y sexualidades habiten y coexistan en el espacio de lo público y lo privado en tanto testigos de la diversidad de nuestro tiempo.
Filosofía rusa en polaco. ¿Un ejemplo para el mundo hispanoparlante?
Authors: Morillas Esteban Jordi
Published: June 2023

Se ofrece una presentación contextualizada de cuatro autores aparecidos en una reciente colección de filosofía rusa de la denominada "Edad de plata" con el fin de darla a conocer al lector español e incentivar su traducción a nuestro idioma.
EDUCACIÓN FÍSICA INFANTIL. GRADO EN EDUCACIÓN INFANTIL. DOBLE GRADO EN EDUCACIÓN INFANTIL Y EDUCACIÓN PRIMARIA
Authors: Gómez Mármol Alberto , Cifo Izquierdo María Isabel , Ureña Ortín Nuria
Published: June 2023

El presente texto guía pretende reconocer el planteamiento multidisciplinar que implica la formación del maestro de Educación Infantil, así como la aportación que realiza la asignatura Educación Física Infantil como área de significatividad relevante para esta etapa. Por ello, es elemental profundizar en el conocimiento de los contenidos básicos que conforman la Educación Física, así como el papel que tiene en el desarrollo integral de los escolares en estas edades. Así, se plantea un texto guía con 3 temas teóricos sobre la motricidad, las actividades para desarrollar conductas motrices y el desarrollo motor con sus respectivas clases prácticas.
Coeval Dancefutures in the Nordics
Authors: Fiksdal Ingri Midgard
Published: June 2023

This paper looks at the conceptual boundaries of dance-as-art in the Nordics and discusses strategies towards coeval dancefutures away from contemporaneity as a colonial idea(l) of time. The future of dance-as-art in the Nordics needs to be pluralised for the artform to be representative of the regional demography and, as such, stay relevant. This paper proposes two research strands that can contribute to this pluralisation. The first investigates how the conceptual boundaries of dance-as-art shape the leading dance education courses in the Nordics in terms of curricula and student mass, and how these could be expanded. The second strand focuses on diversifying the professional field through artistic research in choreography as a format of speculative future fiction that can suggest new, coeval dancefutures.

Dance-as-art is frequently equated with the genre referred to as Contemporary Dance, a highly contradictory term. Rather than denoting all dance forms of the present, it commonly implies a specific set of formalized dance techniques and choreographic formats derived from Western-European and North American modern dance of the twentieth century. Contemporary Dance holds a somewhat exclusive access to formal dance education, art funding as well as networks of dissemination and distribution in the Nordics. Other dance forms are often met with a denial of coeavalness by the Contemporary Dance field, hence largely excluded from the realm of art.

This paper argues for the creation of structures for a large variety of coeval dancefutures through revising professional and ethical standards in the Nordic dance field. Instead of continuing to claim the defining power of what constitutes dance-as-art, those of us who currently do have access to education, funding, and dissemination need to take responsibility for challenging and expanding these systems to create a diverse, cultural sustainability within dance-as-art.
How to Resolve the Trauma of Exile?
Authors: Nõmm Martin
Published: June 2023

The Estonians, Latvians, and Lithuanians who were forced to leave their respective homelands after World War II in the wake of Soviet occupation came to form exile communities across the world. These communities continued their cultural traditions and practices with the arts becoming a medium to reaffirm their identities in exile and narrate their experiences. But with a quarter of a century having passed since their migration, the 1970s became a period of re-evaluating this focus, often represented by topics of generational conflict or inability to change with the times. In North America, first generation Baltic exile playwrights Ilmar Külvet, Alfreds Straumanis, and Algirdas Landsbergis often scrutinized the condition of exile within their works. In this study, I will examine the Baltic narrative of exile as a cultural trauma and take into focus three works by these authors with representations reflecting on the changing times and crises of belonging and identity. The three plays also present a way out of these tensions and can be considered deliberate efforts by the authors to shift cultural discourse and explore other creative potentials of exile, best facilitated by negotiating between the old and the new, the traumatic past, and the ever-changing present.
Precarization in the Name of Freedom
Authors: Farcas Liliana , Holgersson Helena
Published: June 2023

This article is written within the frame of the interdisciplinary research project “Expansion and Diversity: Digitally Mapping and Exploring Independent Performance in Gothenburg 1965–2000”. It contributes to the critical ambition of producing an inclusive historiography of local independent performing arts groups by exploring the municipal distribution of cultural grants and the material conditions in the field. Based on interviews with nine well-known members of early independent performing arts groups in Gothenburg, complemented with archived funding applications and news articles, the article uses a cultural studies perspective to elaborate on how artistic freedom was negotiated in relation to dependence on public funding.
Actors as Co-Creators in Contemporary Latvian Theatre
Authors: Rodiņa Ieva
Published: June 2023

In Latvian theatre, the last decade has been a time of significant changes regarding the working methods of independent theatre movements. Two of the oldest independent theatres in Riga – Dirty Deal Teatro and Ģertrūde Street Theatre – have become a centre for various theatre productions, therefore moving towards the model of state repertoire theatres. Meanwhile, in recent years, several new theatre companies and creative groups have appeared in the field. Theatre troupe KVADRIFRONS, formed by four young actors having just graduated from the Latvian Academy of Culture, as well as the theatre company esARTe, led by director and teacher Elmārs Seņkovs and the ‘scandalous’ young actors trained in the so-called puppet theatre course at the Latvian Academy of Culture, – these are just a few examples of the new creative formations in Latvian theatre. While in repertoire theatre the creative process mostly lies on the shoulders of the stage director, the aforementioned theatre companies highlight the importance of the actor as co-creator – both in the artistic (devised theatre methods), and the administrative process (actors as managers, etc.). Has the profession of actor changed from performer to administrator? How does the administrative status of the newly founded theatre companies influence the work of freelance actors? How has the status of the actor changed in today’s society? The research tackles the topic of actor as co-creators focusing on the examples and experiences of new independent Latvian theatre companies and including significant social, as well as aesthetical aspects.
Reduce, Reuse, or Refuse?
Authors: Balcare Kitija
Published: June 2023

Taking into account that the performing arts could play a huge role in shaping the ecological awareness of society, it is important not only to look at the econarratives of performances but also to analyse the process of their production in terms of sustainability. Reduce, reuse, and recycle – these are essential components of environmentally responsible consumer behaviour. But what about the theatre scene? What are the main challenges for theatre professionals in terms of their ecological footprint? Despite the fact that theatre has been perceived as anti-ecological per se, the first signs of a shift in the mindset of theatre makers is already visible. There has been an increase in ecotheatre performances that not only use ecodramaturgy and represent crucial econarratives pertaining to environmental conservation but also apply aspects of sustainability in the production process of the performances. Such aspects are important in regard to the conviction that ecotheatre is becoming a form of environmental activism. During the recent pandemic (2020–22), several performances in Latvia were based on ecodramaturgy and contained features of ecotheatre. This paper aims to explore the latest sustainable practices and ecological aspects in the theatre scene in Latvia.
”Unge, eksistens og Covid19”
Authors: Andersen Aida Hougaard , Viftrup Dorte Toudal , Bank Mads
Published: June 2023

Den Covid19-relaterede samfundsmæssige nedlukning kan ses som en krise, der kan forstyrre unges værens-betingelser og tydeliggøre eventuelle eksistentielle udfordringer. Covid19- nedlukningen kan dermed benyttes som en synkron indgang til at belyse de eksistentielle dimensioner af unges liv, hvordan de håndterer kriser, og hvilke psykologiske, sociale og trivselsmæssige følgevirkninger forandringerne i deres livsbetingelser har. Studiet ønsker derfor at udforske: Hvordan oplever unge sig selv og det, der er vigtigt for dem i livet, og hvilke eksistentielle temaer træder frem i relation til Covid19? Studiet anvender en kvalitativ forskningsmetodologi. Analysen anvender udvalgte begreber fra Søren Kierkegaard, Martin Buber og Martin Heidegger i interaktion med interviewmaterialet til fortolkningen af deltagernes oplevelser. Via semistrukturerede interviews blev 19 unge interviewet på Zoom de første dage efter skolernes åbning efter anden Covid19-nedlukning. 16 piger og 6 drenge mellem 16 og 17 år deltog. Interviewene varede mellem 15 og 46 minutter.De unges beskrivelse af Covid19 fokuserede på nedlukningen af samfundet, og de deraf ændrede værens-betingelser tydeliggjorde et alternativ til en præstationsorienteret tilværelsestolkning. Fortolkningen af analysens temaer peger på, at den etiske livsfære og det mellemmenneskelige møde af affektiv karakter er afgørende for de unges vej igennem eksistentielle udfordringer og oplevelsen af at være og blive sig selv. Studiets fund kan bidrage til prioritering i pædagogisk praksis og til et generelt fokus på betydningen af eksistentiel sundhed, og dermed forebyggelse af mistrivsel og mentale udfordringer blandt unge.
Refleksioner over spiritualitet i psykoterapi
Authors: Frøyr Hanne
Published: June 2023

I essayet påstås det, at spiritualitet og åndelighed  er blevet udelukket fra psykologien, og at dette kan have den konsekvens, at mennesker ikke får den hjælp, de har brug for, når de er i krise og henvender sig til en psykolog. Der reflekteres over, hvad spiritualitet er, hvorledes den kan inddrages i psykoterapi, og hvilke krav det stiller til behandlerne.
Resource Use Efficiency and Profitability Analysis of Catfish (Clarias gariepinus) Production in Kogi State, Nigeria
Authors: Oyewole B. O. Oyewole , Ibitoye S. J. , Adejo P. E. , Oyibo F. O.
Published: June 2023

Understanding the resource use efficiency and profitability in catfish production is essential for maximizing productivity, minimizing environmental impact, and ensuring sustainable economic growth in the aquaculture industry. This study assessed the resource use efficiency and profitability analysis of catfish (Clarias gariepinus) production in Kogi State, Nigeria. Primary data obtained through questionnaire administration to one hundred and sixty (160) catfish farmers in the State were analysed using descriptive statistics, Cobb-Douglass production function, efficiency ratio, gross margin, and mean score from the Likert type of scale. The result showed that 68.12 percent of catfish farmers in the State were males in a productive age of 48 years. The major catfish farming practices/enterprise combination include; sole catfish farming (78.75 percent), fish cum vegetable (44.38 percent) and fish cum poultry (40.63 percent). Analysis of the resource use efficiency showed that fingerlings, labour and vaccines were underused while feed, pond and fuel were overused by catfish farmers in the State. The calculated gross margin among catfish farmers is N2, 110,136.01k with a profit of N1, 333,910.54k, indicating the net financial gain from the catfish production after deducting all costs. The benefit-cost ratio (BCR) is 1.32, suggesting that for every unit of cost invested in catfish production, there is a return of 1.32 units in revenue. The serious constraints faced by catfish farmers include; inadequate finance (mean score = 2.88), high cost of feed (mean score = 2.87), inadequate power supply (mean score = 2.66), cannibalism (2.42), inadequate processing experience (mean score = 2.32), and low market price (mean score = 2.21). Among others, the study recommended that, the State government should: implement policies that promote access to quality inputs, provide technical assistance and training to catfish farmers, facilitate market access, and create an enabling business environment.
Blood Pressure Values in Apparently Healthy Sudanese Population
Authors: Hago Elnagi Y. , Bashir Amir A. , Abdalla Isam M. , Taha Elmutaz E. , Mohamed Abdelmuhsin H. , Awad Kamal , Abeadalla Abdarahiem A. , Ali Ibrahim A. , Musa Omer A.
Published: June 2023

Introduction: Blood pressure is one of the most often measured clinical parameters, and assessment of blood pressure has a considerable impact on diagnostic decisions.

Objectives: To establish blood pressure normal reference values in Sudanese.

Methods: A cross-sectional study was conducted from September 2016 to November 2018. Eight hundred eighty-eight healthy adult Sudanese between the ages of 18 and 60 (203 men and 685 women) were randomly selected from the states of Khartoum, Northern, Gezira, Red Sea, and North Darfur. Clinical, anthropometric, and blood pressure measurement data were collected.

Results: The mean for all volunteers was 113.93 ± 9.917 mmHg, systolic blood pressure (SBP) and 75.29 ± 6.79 mmHg, diastolic blood pressure (DBP). SBP in men was 118.6 + 7.642 mmHg compared to 112.53 + 9.121 mmHg in women, while DBP in men was 77.51 + 5.984 mmHg compared to 74.63 + 6.844 mmHg in women. Beside the gender variations, blood pressure values also showed geographical variability. There was a positive connection between blood pressures (SBP and DBP), BMI, and age. (P < 0.05) was used for significance.

Conclusion: Blood pressure of Sudanese was found to be within the normal international range with gender and geographical variability. It showed positive correlation with age and BMI.
Genetic Variability and Diversity Analysis for Yield and its Associated Traits in Chickpea (Cicer arietinum L.)
Authors: Mihoariya Manisha , Tiwari Sushma , Yadav Rakesh Kumar , Asati Ruchi , Solanki R. S. , Tiwari P. N. , Chauhan Shailja , Tripathi Niraj , Tripathi Manoj Kumar
Published: June 2023

Chickpea (Cicer arietinum L.) is a leguminous self-pollinating crop belongs to family- Leguminosae (Fabaceae). The aim of a plant breeder is to identify or develop high yielding cultivars. In the present investigation, 83 genotypes grown during Rabi 2021-22 to investigate genetic variability, heritability and genetic advance, correlation, direct and indirect effects and genetic divergence (D2 analysis) among yield and its attributing traits. High GCV and PCV recorded for the numbers of pods per plant and biological yield indicating the presence of substantial amount of genetic variability in the experimenting material. High heritability coupled with high genetic advance was shown for seed yield per plant, hundred seed weight. Selection based on these traits may be proved worthwhile. Significant and positive correlation was documented for seed yield per plant with numbers of pods per plant and biological yield and path analysis signified that biological yield had the highest positive direct effect on seed yield per plant. The data obtained from the present investigation may be proved helpful in the selection of high yielding superior genotype (s) of chickpea.
Interactive Effect of Conservation Tillage, Potassium and Magnesium Sulphate Fertilization on Dry Matter Production, Physiological and Yield Parameters, and Yield of Grain Cowpea
Authors: Pai Vandana G. , Prameela P. , Vijayan Roshni
Published: June 2023

This study conducted in Kerala, evaluated the role of conservation tillage (zero tillage (ZT), minimum tillage (MT), and conventional tillage (CT)) with five treatment combination of potassium (12 kg/ha, 20 kg/ha, 40 kg/ha) and magnesium sulphate (60 kg/ha and 80 kg/ha) on total DMP, physiology and grain yield of the test variety Anaswara (cowpea). In pot culture study, application of K: MgSO4, 10:80 kg/ha resulted in highest total chlorophyll content. While higher chlorophyll a content was obtained with the levels 20:60 kg/ha, and highest total DMP was recorded with the application at  40:100 kg/ha. Different levels of K and MgSO4 nutrition positively influenced 100 seed weight and grain yield, while there found no significant difference on chlorophyll b content, days to flowering, and grains/pod with any of the treatments imposed. Higher values for test weight and grain yield were recorded with K: MgSO4 40:60 kg/ha. In field experiment, tillage practices failed to produce notable difference in chlorophyll a, chlorophyll b, total chlorophyll contents, chlorophyll a/b ratio, grains per pod and test weight. Early flowering (45 DAS) and highest total DMP up to 75 DAS were recorded under CT. ZT produced highest LAI, while highest grain yield was noted under MT practice (734.5 kg/ha). Nutrient treatments failed to produce significant differences in chlorophyll b and chlorophyll a/b ratio. However, application at 40:80 kg/ha produced highest LAI, and higher content of chlorophyll a and total chlorophyll content (1.34 mg/g). K:MgSO4 applied at 40:60 kg/ha recorded highest grain yield.  LAI was recorded highest under ZT with K:MgSO4 at 40:80 kg/ha. MT + K:MgSO4 at 40:60 kg/ha reported highest chlorophyll a/b ratio (4.71). K: MgSO4 applied at 40:60 kg/ha produced highest grain yield (806 kg/ha). In interactions, MT + K: MgSO4 at 40:60 kg/ha registered highest grain yield (914.8 kg/ha). Overall, in terms of grain yield, the test crop responded well to MT with application of K: MgSO4 at 40:60 kg/ha.
Influence of Vermicompost and Bio-fertilizers on Growth and Flowering of Tuberose (Polianthes tuberosa L.) cv. Prajwal
Authors: Yadav Ritu , Beniwal Bijender Singh , Dalal Rajpal Singh , Kumar Sushil
Published: June 2023

The experiment was planned to sustainably improve the growth and yield of tuberose using bio-fertilizers and organic manures. performed in pots in completely randomized design (CRD) with 11 treatments having four replications to study the response of organic manures, chemical fertilizers and bio fertilizers on growth and flower yield of tuberose (Polianthes tuberosa L.) cv. Prajwal.  The treatment containing sand + vermicompost (4:1) + Bio-fertilizers (Azotobacter&Pseudomonas sp.) was significantly superior in terms of plant height (70.50 cm), length of leaf (36.98 cm), Number of leaf (25.67), spike length (66.58 cm), rachis length (27.23 cm), diameter of stem (1.096 cm), florets number per spike (35), number of opened florets per spike (33.67), spikes number per clump, spike weight (75.33 g), bulb number per clump (21), bulb diameter (1.20 cm), bulb weight (3.98 g). While lowest values of these parameters were observed in the control (sand). Minimum days taken to bulb sprouting (21.75 days), days taken to complete bulb sprouting (24.50 days), days taken to spike emergence (93 days) and days taken to opening of first floret (106.75 days) were observed   in sand + inorganic manures. Treatment having Sand + vermicompost (4:1) + Bio-fertilizers (Azotobacter&Pseudomonas sp. was observed best to promote growth and flowering of tuberose.
Assessment of the Safety of Aqueous Extract of Maize (Zea mays) Husks in Wistar Albino Rats
Authors: Odelola Olanrewaju Samson , Oyetayo Victor Olusegun , Ogundare Ayodele Oluwayemisi , Ogunlade Babatunde
Published: June 2023

Aims: The possible toxic impact of aqueous extract of maize husks (HA) on Wistar albino rats was investigated.

Study Design: Experimental design.

Place and Duration of Study: This study was conducted at the Federal University of Technology, Akure, Nigeria between January 2020 and April 2020.

Methodology: The extract was prepared adopting the cold extraction procedure. Forty-eight (48) Wistar albino rats were used for this study. Acute toxicity study was carried out by administering HA at a single dose of 2000, 4000 and 8000 mg/kg body weight to the rats by oral gavage. The rats were observed for 14 days for any mortality or signs of toxicity. For sub-acute study, doses of 200, 400 and 800 mg/kg body weight were orally administered daily for 28 days. Biochemical and haematological parameters as well as histopathological studies were carried out after the experiments.

Results: Acute toxicity results indicated that the median lethal dose (LD50) of HA was greater than 8000 mg/kg. There was remarkable body weight gain (P ≤ 0.05) in both male and female rats in all the sub-acute groups and acute group treated with 8000mg/kg. In the acute and sub-acute toxicity study, slight difference was recorded between the biochemical and haematological parameters of the treated rats dosed with the extract and the control. There was a significant increase in Packed Cell Volume (PCV) of female rats and lymphocytes of male rats treated with 800 mg/mL and 400 mg/mL respectively. The total protein, glucose and urea level of male rats treated with 200 mg/mL reduced while urea level of females treated with 200 mg/mL and 400 mg/mL also reduced remarkably. However, histological data showed no significant difference.

Conclusion: In general, the extract was found to show no toxic effect on the rats and hence it is safe for potential therapeutic use.
Zavegepant Nasal Spray for Treatment of Acute Migraine: A Systematic Review
Authors: Odoma Victor Ameh , Nwabueze Daniel , Alam Benish , Olaleye Kehinde Tolulope , Louise-Oluwasanmi Olusayo , Ballagan Jashanpreet Singh , Rahman Farzana , Nayab Khudija , Abung Akata , Chukwuneta Chidera Precious , Sadare Oluwaseun Christiannah , Hassanain Sahar , Okoye Chiugo , Okunromade Omolola , Adabanya Uzochukwu
Published: June 2023

Background: Migraine is a widespread neurological disorder that can impair quality of life. Current treatments are often insufficient, with side effects causing some patients to seek alternative options. Zavegepant nasal spray, a new treatment being developed for acute migraine, shows promise in blocking the CGRP receptor and providing several potential advantages, such as faster onset of action and higher bioavailability. This systematic review aimed to assess the efficacy and safety of Zavegepant nasal spray in treating acute migraine attacks and identify adverse events.

Methods: Adult patients diagnosed with acute migraine who were treated with Zavegepant nasal spray in randomized controlled trials (RCTs) or non-randomized clinical trials were included. A comprehensive search was conducted in PubMed, Embase, Cochrane Library, and ClinicalTrials.gov until March 2023. The following keywords were employed: "Zavegepant nasal spray", "migraine", "calcitonin gene-related peptide receptor antagonist." A narrative synthesis was conducted to summarize and analyze the extracted data from the included studies, with a focus on the efficacy and safety of Zavegepant nasal spray for the treatment of acute migraine.

Results: This systematic review included three clinical trials, of which two were RCTs, and one was an open-label trial. The total number of participants was 3681, and all of them were in phase 2/3 of testing. The inclusion criteria for these trials were broadly based on individuals who had a history of migraines with or without aura lasting for over a year, which is consistent with the third edition of the International Classification of Headache Disorder. The findings were tabulated and discussed.

Conclusion: Zavegepant nasal spray is an effective and well-tolerated treatment for acute migraines. Further research is needed to confirm its safety and efficacy, optimal dosing and administration, and effectiveness in different populations. The cost-effectiveness, patient satisfaction, and long-term effects on migraine burden ought to be investigated.
Gendered Practice of Naga Customary Laws: A Critical Analysis
Authors: Yanthan E. Chumthunglo
Published: June 2023

The Nagas are culturally and linguistically a diverse society situated in the North-eastern part of India. One of the common characteristics that Nagas share in culturally diverse region is the practice of customary laws although each tribe differs in varying degree of its usages and practices. Overall customary law act as a keeper and binds the community together. However, customary laws are not always conductive to modern development especially with regards to gender rights. Under customary laws, the distribution of power, status and resources have always been male centred. It is a male dominated arena based on discriminatory rules that invariably pose a great constraint on women to progress equally in the society. Accordingly, against this background, the paper critically analyses Naga traditional and customary law practices from gender perspective and examine its implication on women rights. It evaluates some of its intricate dimension of gendered meaning attached to certain symbolic function in the traditional practices of the Nagas which inadvertently constructed men as naturally superior and thereby resulted in the subjugation of women. Further, the paper attempts to address the impeding gender issues by offering feminist perspective of constructivist approach to culture as a means of alternative solution in the face of conflict between gender rights and customary laws.
Tool Condition Monitoring with Convolutional Neural Network for Milling Tools and Turning Inserts
Authors: Rifai Achmad Pratama , Briliananda Silvyaniza , Aoyama Hideki
Published: June 2023

Tool wear is one of the cost drivers in the manufacturing industry because it directly affects the quality of the manufactured workpiece and production efficiency. Identifying the right time to replace the cutting tool is a challenge. If the tool is replaced too soon, the production time can be disrupted, causing unscheduled downtime. Conversely, if it is replaced too late, there will be an additional cost to replace raw materials damaged by broken tools. Therefore, researchers continue to develop tool condition monitoring (TCM) methods to analyze tool wear. A recent popular method is machine vision with convolutional neural networks (CNN). The present research aims to develop classification models that can categorize the image data of milling and turning inserts into GO (suitable for use) and NO GO (not suitable for use). Two approaches are selected for the modeling process, custom learning and transfer learning, with image data input from smartphones and microscope cameras. The experimental results show that the best model is the transfer learning approach using Inception-V3 architecture with a smartphone image. The model reaches 92.2% accuracy, hence demonstrating a relatively good performance in determining whether the tool is suitable for use or not.
Determinants of Online Impulsive Buying Post Pandemic Covid-19
Authors: Andreani Fransisca , Anastasia Njo , Foedjiawati Foedjiawati
Published: June 2023

During the Covid-19 pandemic, the use of social media has increased in line with online buying transactions. This research was conducted to find out online impulsive buying due to the large amount of information and promotion spread on social media after the pandemic. Online questionnaires were distributed to 261 respondents who made online transactions. SEM-PLS 3.0. was used to analyze the data.  The results prove that hedonic browsing has a significant influence on flow experience. Flow experience has a significant influence on cognitive experience and affective experience as well as online impulsive buying. Cognitive experiences have significant influence on online impulsive buying. However, affective experiences do not have a significant influence on online impulsive buying. Moreover, financial management behavior cannot moderate the relationship among cognitive and affective experiences as well as online impulse buying. Theoretically, the study shows that irrational consumption processes lead to hedonic shopping due to easy and convenient searching for products through social media. Thus, in practice it is advisable for marketing managers to design their promotions on social media related to products and interspersed with financial literacy so that consumers can shop wisely.
As mulheres sob ataque:
Authors: Mantovani Emanuele , Areosa Silvia Virginia Coutinho
Published: June 2023

Este artigo teórico tem como objetivo discutir a relação entre o novo modelo neoliberal, o conservadorismo e a desdemocratização com a retirada de direitos e os ataques às políticas de gênero. Este novo modelo, que propõe não só uma política econômica, mas também uma racionalidade conservadora e antidemocrática tem como lastros a chamada ideologia de gênero e a necropolítica. A partir de uma pesquisa bibliográfica, esse trabalho conecta o novo neoliberalismo, seus produtos (conservadorismo e desdemocratização) e subprodutos (ideologia de gênero e necropolítica) a serviço de um modelo que aprofunda o domínio do capital sobre a sociedade e de forma mais aguda e violenta sobre as mulheres, impondo um retrocesso histórico à agenda feminista.
Desigualdade de gênero e educação:
Authors: Parisoto Dyeniffer Jessica Bezerra , Favoreto Aparecida
Published: June 2023

O artigo, por intermédio da compreensão de estudantes, aponta como a desigualdade de gênero e a cultura machista são discutidas e vivenciadas no ambiente escolar. Para tal, foi realizada pesquisa bibliográfica para apreender o processo histórico da educação feminina e também pesquisa de campo com alunos/as do Ensino Médio de Cascavel-PR. Tais temas são estudados em aulas, o que contribui para a conscientização, entretanto, no ambiente escolar, permanecem as diferenças, já que se efetiva uma naturalização, inclusive, da cultura machista. Tal fator explicita a necessidade de repensar a educação para que possa contribuir à superação da desigualdade de gênero e à diminuição da cultura machista.
Pessoas com deficiência, roupa e autoestima:
Authors: Conceição Vanessa dos Santos da , Nery Maria Salete de Souza
Published: June 2023

Esse artigo discute a relação entre imagem social, autoimagem e autoestima a partir da relação entre a pessoa com deficiência, a roupa e a questão da representatividade. Uma imagem social e autoimagem negativas impactam a percepção a respeito do que se pode usar, quando e onde, podendo gerar sentimentos de inadequação e vergonha. Tais sentimentos se acentuam na medida em que não se encontra ou se encontram poucas referências positivas nas quais é possível se apoiar (representatividade), como ocorre com as pessoas com deficiência. Uma vez que depoimentos publicados nas redes sociais apresentaram a relação com a roupa como um tema recorrente, investigamos o projeto de resistência #pcdsnacapa, que reconstrói capas de revistas, mas com pessoas com deficiência como personagens centrais. O que pudemos perceber é a agência de pessoas na busca por representatividade e mudança na imagem social e autoimagem e o lugar que a roupa desempenha nesse processo como instrumento não apenas de expressão de si, mas também de reconstrução de si.
Highlights From the ASCO Annual Meeting—New Approaches to Cancers of the Blood, Brain, Lung, and More
Authors: Suran Melissa
Published: June 2023

This Medical News article discusses new research presented at the American Society of Clinical Oncology’s 2023 annual meeting.
Trichothiodystrophy
Authors: Garon Laurence , Kokta Victor , Coulombe Jérôme
Published: June 2023

This case report describes an infant with frizzy, coarse, and fragile hair and low-set ears, blepharophimosis, and osteopenia.
Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
Authors: Wang Xiaofei , McCaw Zachary R. , Tian Lu , Stinchcombe Thomas E. , Vokes Everett , Ludmir Ethan B. , Wei Lee-Jen
Published: June 2023

This cohort study demonstrates how to use cumulative event count curves to create a clinically meaningful end point by simultaneously considering recurrence, progression, and survival times from the individual patient.
High-definition Cathodal Direct Current Stimulation for Treatment of Acute Ischemic Stroke
Authors: Bahr-Hosseini Mersedeh , Nael Kambiz , Unal Gozde , Iacoboni Marco , Liebeskind David S. , Bikson Marom , Saver Jeffrey L. ,   TESSERACT Trial Group, Sanossian Nerses , Wu Allan , Dobkin Bruce , Avila Gilda
Published: June 2023

Importance

Cathodal transcranial direct current stimulation (C-tDCS) provides neuroprotection in preclinical models of acute ischemic stroke (AIS) by inhibiting peri-infarct excitotoxic effects and enhancing collateral perfusion due to its vasodilatory properties.

Objective

To report the first-in-human pilot study using individualized high-definition (HD) C-tDCS as a treatment of AIS.

Design, Setting, and Participants

This randomized clinical trial was sham controlled with 3 + 3 dose escalation design, and was conducted at a single center from October 2018 to July 2021. Eligible participants were treated for AIS within 24 hours from onset, had imaging evidence of cortical ischemia with salvageable penumbra, and were ineligible for reperfusion therapies. HD C-tDCS electrode montage was selected for each patient to deliver the electric current to the ischemic region only. Patients were followed for 90 days.

Main Outcomes and Measures

Primary outcomes were feasibility, assessed as time from randomization to study stimulation initiation; tolerability, assessed by rate of patients completing the full study stimulation period; and safety, assessed by rates of symptomatic intracranial hemorrhage at 24 hours. The efficacy imaging biomarkers of neuroprotection and collateral enhancement were explored.

Results

A total of 10 patients with AIS were enrolled, 7 were randomized to active treatment and 3 to sham. Patient age was mean (SD) 75 (10) years old, 6 (60%) were female, and National Institutes of Health Stroke Scale score was mean (SD) 8 (7). Two doses of HD C-tDCS (1 milliamp [mA] for 20 minutes and 2 mA for 20 minutes) were studied. The speed of HD C-tDCS implementation was a median (IQR) 12.5 minutes (9-15 minutes) in the last 4 patients. Patients tolerated the HD C-tDCS with no permanent stimulation cessation. The hypoperfused region was reduced by a median (IQR) 100% (46% to 100%) in the active group vs increased by 325% (112% to 412%) in sham. Change in quantitative relative cerebral blood volume early poststimulation was a median (IQR) 64% (40% to 110%) in active vs −4% (−7% to 1%) sham patients and followed a dose-response pattern. Penumbral salvage in the active C-tDCS group was median (IQR) 66% (29% to 80.5%) vs 0% (IQR 0% to 0%) in sham.

Conclusion and Relevance

In this randomized, first-in-human clinical trial, HD C-tDCS was started efficiently and well tolerated in emergency settings, with signals of beneficial effect upon penumbral salvage. These results support advancing HD C-tDCS to larger trials.

Trial Registration

ClinicalTrials.gov Identifier: NCT03574038
Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma
Authors: Hedegger Kathrin , Blutke Andreas , Hommel Theresa , Auer Kerstin E. , Nataraj Nishanth B. , Lindzen Moshit , Yarden Yosef , Dahlhoff Maik
Published: June 2023

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the effects on pancreatic lesions, we attempted simultaneous blockade of all ERBB ligands in a PDAC mouse model. To this end, we engineered a molecular decoy, TRAP‐FC, comprising the ligand‐binding domains of both EGFR and ERBB4 and able to trap all ERBB ligands. Next, we generated a transgenic mouse model (CBATRAP/0) expressing TRAP‐FC ubiquitously under the control of the chicken‐beta‐actin promoter and crossed these mice with KRASG12D/+ mice (Kras) to generate Trap/Kras mice. The resulting mice displayed decreased emergence of spontaneous pancreatic lesion areas and exhibited reduced RAS activity and decreased activities of ERBBs, with the exception of ERBB4, which showed increased activity. To identify the involved receptor(s), we employed CRISPR/Cas9 DNA editing to singly delete each ERBB receptor in the human pancreatic carcinoma cell line Panc‐1. Ablation of each ERBB family member, especially the loss of EGFR or ERBB2/HER2, altered signaling downstream of the other three ERBB receptors and decreased cell proliferation, migration, and tumor growth. We conclude that simultaneously blocking the entire ERBB receptor family is therapeutically more effective than individually inhibiting only one receptor or ligand in terms of reducing pancreatic tumor burden. In summary, trapping all ERBB ligands can reduce pancreatic lesion area and RAS activity in a murine model of pancreatic adenocarcinoma; hence, it might represent a promising approach to treat PDAC in patients.
Liver X receptors induce antiproliferative effects in basal‐like breast cancer
Authors: Haugen Mads Haugland , von der Lippe Gythfeldt Hedda , Egeland Eivind Valen , Svartdal Normann Lisa , Pandya Abhilash D. , Vedin Lise‐Lotte , Juell Siri , Tenstad Ellen , Øy Geir Frode , Kristian Alexandr , Marangoni Elisabetta , Sørlie Therese , Steffensen Knut , Mælandsmo Gunhild Mari , Engebraaten Olav
Published: June 2023

Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a therapeutic opportunity in cancers lacking targeted therapies, such as triple‐negative breast cancer. In this study, we investigated the impact of LXR agonists alone and in combination with carboplatin in preclinical models of breast cancer. In vitro experiments revealed a dose‐dependent decrease in tumor cell proliferation in estrogen receptor‐positive breast cancer cells, whereas LXR activation in vivo resulted in an increased growth inhibitory effect in a basal‐like breast cancer model (in combination with carboplatin). Functional proteomic analysis identified differences in protein expression between responding and nonresponding models related to Akt activity, cell‐cycle progression, and DNA repair. Furthermore, pathway analysis suggested that the LXR agonist in combination with carboplatin inhibits the activity of targets of E2F transcription factors and affects cholesterol homeostasis in basal‐like breast cancer.
Assessing the impact of festival music on bat activity
Authors: Hooker Jack , Daley Emma , Stone Emma , Lintott Paul
Published: June 2023

Sound is a critical component of an animal's habitat, where it is used to glean important environmental information from their surroundings. The modification of natural soundscapes due to the global rise in anthropogenic noise pollution over recent decades can have serious negative impacts on species fitness and survival.

Nocturnal species such as bats are reliant on sound for many aspects of their life history and are, therefore, highly sensitive to anthropogenic noise. Music festivals are a source of unregulated and potentially harmful, acute noise pollution; however, they have become ubiquitous across our landscapes throughout the summer months and are increasingly being held in settings important for wildlife.

Using an experimental approach, we provide the first evidence of the negative impacts of music festivals on bat activity in a habitat that represents a typical festival setting, that is, woodland edge. We found that loud music playback alone can reduce the activity of bats even in the absence of other anthropogenic factors commonly associated with music festivals such as lighting and habitat disturbance. Activity of Nyctalus/Eptesicus spp. was reduced along woodland edge habitats exposed to loud music, whereas no effect was recorded for Myotis spp., Pipistrellus pygmaeus and Pipistrellus pipistrellus compared with quiet nights. We also provide the first evidence of the spatial scale of negative effects from festival music on activity for P. pygmaeus as well as highlighting differential responses between cryptic species.

In light of the paucity of research or guidance into acute noise impacts on nocturnal biodiversity, we outline the potential negative impacts of music festivals for bats. We show that music alone can reduce the activity of bats even in the absence of other anthropogenic factors commonly associated with music festivals, which could potentially fragment important habitats for certain species, leading to a degradation of functional connectivity across the landscape.