bluuebunny/crossref_metadata_2025 huggingface dataset:
If You Want to Say Something—Speak in the Language of the Language: Ewa Partum's Model of Conceptual Art
Authors: Majewska-Güde Karolina
Published: July 2021

The artistic practice of the Polish-born Ewa Partum can be divided chronologically into Polish (1965–1982), West Berlin (1982–89) and transnational / global (from 1989) periods. This essay focuses on the specificity of the conceptual art developed by Partum and her self-historicization as a conceptual artist. At the same time, it regards the local and global historicization of conceptual art as fragmentary and contradicting processes. The study examines local genealogy of Partum's conceptual strategies as part of a localized reflection on the geopolitics of knowledge; it considers a specific position of cultural production that is characteristic of Central and Eastern European neo-avant-gardes. It examines Partum's model of conceptual art in relation to Polish and Western practices. It is argued that Western conceptualism was only a point of reference for Partum's art. Works such as Presence / Absence or Luncheon on the Grass realized by Partum in years 1965–1972 formed a basis from which the artist responded to knowledge of the transnational conceptual movement that was disseminated through Mail Art and Fluxus networks. Analysis reveals Partum's model of conceptual art to be contrapuntal, as it is not subordinate to either its western inflection or local (Polish) cannons and protocols.
Australian Resource Reviews: Antimony 2020
Authors: Britt Allison , Senior Anthony
Published: July 2021

Statistics and commentary on Australia's antimony ore reserves and mineral resources, including information on current exploration, known deposits and operating mines as at June 2021.
A new species of the enigmatic genus Oressinoma Doubleday from the Andes of central Peru (Lepidoptera: Nymphalidae, Satyrinae)
Authors: FLORCZYK KLAUDIA , FÅHRAEUS CHRISTER , BOYER PIERRE , ZUBEK ANNA , PYRCZ TOMASZ W.
Published: July 2021

A new, and only the third known species of the Neotropical montane genus Oressinoma Doubleday is described—O. sorina n. sp., from the Andes of central Peru. It is distinguishable immediately from the other two congeners by the shape of the hindwing underside submarginal orange band, and by the male genitalia. The systematics of Oressinoma are reviewed. A preliminary analysis is carried out based on COI barcode confirming the separate specific status of O. sorina n. sp. in relation to other two congeners. Both barcode and genital morphology data suggest that the widespread O. typhla Doubleday may be a complex of allopatric or, locally parapatric species. The genus Oressinoma is the only neotropical member of the predominantly Australian subtribe Coenonymphina, represented in the entire Holarctic by one genus only—Coenonympha Hübner, considered as the putative sister-genus of Oressinoma. Their origins and relationships are briefly discussed.
Free Trade vis-à-vis Morality: Revisiting the Public-Morals Exception Clause in the World Trade Organization
Authors: Sarkar Swargodeep
Published: July 2021

The most sanctified obligation of the World Trade Organization (WTO) is the promotion and facilitation of international trade and liberalisation of the world economy. Although WTO members are committed to the WTO principle of free flow of goods and services among its members, the WTO permits its members to retain certain regulatory powers under its system to impose trade-restrictive measures based on certain exceptions, like, among other things, public morality under Article XX(a) of the General Agreement on Tariffs and Trade (GATT, 1994). Nevertheless, the question remains: what is public morality for a WTO member, and how far may this clause be invoked in defence of adopting trade-restrictive measures? Recently, the WTO panel on the US tariff case revived the long-standing debate on international trade versus public morality. Is a WTO member free to choose any trade-restrictive measure under the cloak of public morality? Then, what mechanism has the WTO panel/AB (Appellate Body) envisaged to check WTO members from adopting any trade-restrictive measure based on public morals? This article tries to answer these questions by analysing previous WTO disputes related to trade and morality. Against this background, this article looks back at the history of the public-morals exception clause, revisits previous WTO case laws on the public-morals exception and tries to ascertain the precise meaning of public morality—how the WTO Dispute Settlement Body (DSB) checks and balances two conflicting principles, that is, the right to regulate and the principle of free trade—and whether WTO has successfully developed a coherent jurisprudential approach to deal with contradictory interests, that is, trade versus morality.

JEL Codes: F, F1, F13
Do you have to be mad to believe in conspiracy theories? Personality disorders and conspiracy theories
Authors: Furnham Adrian , Grover Simmy
Published: July 2021

This study explored the relationship between belief in conspiracy theories and the personality disorders. A sample of 475 British adults, aged around 30 years, completed measures of Belief in Conspiracy Theories (CTs) and the Personality Disorders (PDs), as well as the SAPAS, a short intelligence test and two self-evaluations. Belief in CTs was correlated with nearly all PDs, as well as the three established higher order clusters (A: odd and eccentric; B: dramatic and emotional; C: anxious). A series of stepwise multiple regressions were computed. A final regression showed five of the variables (education, intelligence, Cluster A, B, and C) were significant, which indicated that less well-educated and less intelligent participants, scoring higher on two PD clusters (Cluster A and B) but lower on Cluster C, believed more in the CTs. Implications of the study for understanding the origin of CTs is discussed. Limitations of the study, particularly the sample and measures used, are acknowledged.
Teachers’ professional collaboration and trust relationships: An inferential social network analysis of teacher teams
Authors: Kolleck Nina , Schuster Johannes , Hartmann Ulrike , Gräsel Cornelia
Published: July 2021

In recent years, teachers around the world have been increasingly confronted with various expectations concerning the improvement of their classroom practices and school activities. One factor widely acknowledged to facilitate school and classroom improvement is a strong collaborative culture among teachers. As such, teachers are expected to work in teacher teams, to collaborate closely with colleagues, to co-construct classroom practices, and thus to strengthen trust relationships within the team. A growing number of researchers has analyzed how teachers address these expectations. They suggest that there is a link between teachers’ embeddedness in collaboration networks and teachers’ trust relationships. The present study seeks to contribute to the research literature by presenting results of Social Network Analyses (SNA) and exponential random graph models (ERGMs) on teacher collaboration in nine secondary schools in Germany (N = 366 teachers). We investigate how the involvement of teachers in co-constructive collaboration in schools, measured by the amount of team teaching (TT), relates to teachers’ trust levels. Results of our analyses suggest that a high amount of TT is not necessarily related to a higher degree of trust among teachers at the school level. However, a high involvement of teachers in TT is related positively to their being perceived as trustworthy. Furthermore, the emergence of trust relations in teacher networks depends on general network characteristics, such as homophily, reciprocity and transitivity.
A new approach to the assessment of changes in air permeability, waterproofness, surface, and thermal properties of polyamide 6.6 fabric with polyurethane coating after washing
Authors: Kowalski Mateusz , Nejman Alicja , Kamińska Irena , Cieślak Małgorzata , Salerno-Kochan Renata
Published: July 2021

The research aim was to analyse the changes in the air permeability, waterproofness, surface, mechanical and thermal properties of the polyamide 6.6 fabric with a polyurethane coating before and after 1, 5, and 10 washes in the same conditions using specialized (V1) and universal (V2) laundry detergent. A new approach based on SEM and DSC techniques and assessment of surface free energy combined with standard methods was proposed to explain the nature of observed changes in waterproof and breathable material after washing treatment. SEM analysis indicated that after 10 washes the porosity of the polyurethane coating increased from 8.94% to 14.56% and 18.75% for V1 and V2, respectively. The air permeability increased from 0.747 mm/s for the reference sample to 0.766 mm/s and 0.774 mm/s after 10 washes for V1 and V2, respectively. The waterproofness of the reference sample of 992 mbar decreased with the increasing number of washes to 246 mbar and 122 mbar for V1 and V2, respectively. After 10 washes the surface free energy (γS) decreased by 18.8% and 24.3% for V1 and V2, respectively. The average tensile strength amounted to 833 N and decreased by 13.5% for V1 and by 20% for V2 after 10 washes. The glass transition temperature of the reference fabric was 47.6°C. After 10 washes it increased by 7.2°C and 8.8°C for V1 and V2, respectively. The temperatures of thermal degradation increased by 24.6°C and 22.2°C and the heat of thermal decomposition decreased by 23.6% and 15.8% after 10 washes for V1 and V2, respectively.
The Resurrection and Unborn Beings: The Seeds of a Materialist Emergence Proposal
Authors: Kamitsuka Margaret D.
Published: July 2021

This article looks at how two apparently unrelated issues—the afterlife and reproductive loss—turn out to be interrelated in complex theological and ethical ways. Eschatology is important to address, because how one thinks about resurrected bodies in the afterlife has implications for how one treats bodies that procreate in this life. Rethinking the notion of personhood lies at the heart of clarifying the nature of the resurrection. This article presents a theological anthropology that draws from the recent philosophical theory known as emergence. This theory allows us to conceptualize the resurrection of the “spiritual body” as a divinely initiated organic process that begins from a “bare seed” at death (1 Cor 15:44, 37). I hope to demonstrate that an emergence model of the resurrection both speaks to those grieving reproductive loss and also avoids eclipsing women’s exercise of moral discernment in reproductive matters.
Computer-Assisted Qualitative Data Analysis Software, Phenomenology, and Colaizzi’s Method
Authors: Vignato Julie , Inman Michaela , Patsais Micayla , Conley Virginia
Published: July 2021

Technology is widely used to support qualitative research. Computer-Assisted Qualitative Data Analysis Software (CAQDAS) encompasses complementary technologies to support qualitative analysis. Advantages of CAQDAS include efficient management of data and transparency in analysis. Disadvantages include heavy emphasis on coding as a distractor from analysis and considerable time to learn the program. In this methods article, we, as less experienced, qualitative researchers describe our experiences using NVivo, a CAQDAS program, in a descriptive phenomenological study using Colaizzi’s method. Over 1 year, 24 postpartum women were given a secure research link to record their experiences with pain and depression during the third trimester of pregnancy. Although NVivo analysis was helpful, the philosophy of phenomenology, reflexivity, and Colaizzi’s method directed researchers away from NVivo for the final summation. Recommendations for future use of CAQDAS used concurrently with Colaizzi’s method include the use of word clouds and other visualizations for bracketing and triangulation.
The platform beat: Algorithmic watchdogs in the disinformation age
Authors: Napoli Philip M
Published: July 2021

As digital platforms have come to play a central role in the news and information ecosystem, a new realm of watchdog journalism has emerged – the platform beat. Journalists on the platform beat report on the operation, use and misuse of social media platforms and search engines. The platform beat can serve as an important mechanism for increasing the accountability of digital platforms, in ways that can affect public trust in the platforms, but that can also, hopefully, lead to the development of stronger, more reliable, and ultimately more trustworthy, platforms. However, there are a number of tensions, vulnerabilities and potential conflicts of interest that characterize the platform beat. This article explores these complex dynamics of the platform beat in an effort assess the capacity of those on the platform beat to enhance the accountability and trustworthiness of digital platforms.
Genesis at work: Advancing inclusive innovation through manufacturing extension
Authors: Lowe Nichola , Schrock Greg , Jain Ranita , Conway Maureen
Published: July 2021

US manufacturing is struggling with both a productivity and job quality challenge. These challenges are interconnected, reinforcing the need for increased coordination of economic and workforce development efforts. This article outlines the evaluation findings of a novel business-facing initiative called the Genesis Movement, to understand its role in reshaping the workforce experience within small- and medium-sized manufacturing businesses in Chicago, Illinois. Spearheaded in 2014 by the Illinois Manufacturing Excellence Center (IMEC), Genesis starts with the premise that workforce practices are central to business operations, productivity, and competitiveness—and therefore, manufacturing extension services need to promote improvements to job quality in support of long-term business success. This integrated approach represents a form of “inclusive innovation,” expanding the capacities of firms and workers to adapt in a competitive environment where pressures to maintain high quality while reducing costs are ever-present. Firms that participate in Genesis learn to adopt an inclusive organizational culture, using front-line worker engagement, skills training, and job quality improvements to drive performance and process innovation. As such, Genesis offers transferable lessons that could be leveraged by other manufacturing-supporting organizations to benefit their industry clients and the workers they employ.
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences
Authors: Ren Honglei , Han Ranran , Liu Xi , Wang Limin , Koehler Raymond C , Wang Jian
Published: July 2021

Post-stroke depression, observed in 30-50% of stroke patients, negatively affects quality of life and mortality. The pathogenesis of post-stroke depression is complex, but heightened reactive oxygen species production and inflammation might be two key factors. We have reported that intracerebral hemorrhage (ICH) in cerebral cortex produces depression-like behavior in young male mice. Here, we found that mice lacking nuclear factor erythroid-derived 2-related factor 2 (Nrf2), a transcription factor that upregulates antioxidant proteins and trophic factors such as brain-derived neurotrophic factor (BDNF), had more severe depression-like behavior than wild-type mice at days 21 to 28 after cortical ICH (c-ICH). Moreover, the expression of Nrf2, heme oxygenase-1, BDNF, and TrkB were significantly decreased in wild-type mice after c-ICH. Interestingly, TP-500 (2 mg/kg), a potent Nrf2 inducer, decreased the inflammatory response and reactive oxygen species production on day 28 after c-ICH and improved depression-like behaviors. TrkB receptor antagonist ANA-12 abolished this anti-depression effect. Depression was more severe in female than in male wild-type mice after ICH, but TP-500 improved depression-like behavior in females. These results suggest that downregulation of Nrf2-BDNF-TrkB signaling contributes to development of post-stroke depression, and that Nrf2 inducer TP-500 might improve depression after c-ICH.
Fuzzy logic control of a hybrid renewable energy system: A comparative study
Authors: Smida Mouna Ben , Sakly Anis
Published: July 2021

In this paper the authors have developed a hybrid renewable energy system. The studied structure comprises a wind energy generator, a shaded photovoltaic generator associated to an inertial storage system. The modeling of the global structure is developed and the control strategy is discussed. Conventional methods have been used to control the renewable sources. However, they may not have a suitable performance if the controlled system contains nonlinearity, as the wind turbine system or the shaded photovoltaic generator. In the presence of modeling uncertainties, the necessity of methods presenting controllers with appropriate performance as the advanced control strategies is inevitable. Fuzzy logic is used to control both the wind generator’s pitch angle and the maximum power point tracking (MPPT) of a shaded photovoltaic generator. The control of the storage flywheel, associated with the studied structure, to regulate the power supplied by renewable sources is also discussed. The design of the proposed strategy and its comparison with conventional controllers are carried out. The proposed method effectiveness is verified by MATLAB simulation results.
How older adults in the USA and India seek information during the COVID-19 pandemic: A comparative study of information behavior
Authors: Lund Brady D. , Maurya Sanjay Kumar
Published: July 2021

The 2020 COVID-19 pandemic introduced significant information challenges for older adults worldwide. Given the widespread disparities in information infrastructure and access between developing and developed countries, the challenges presented during this period may be even more grave in the developing world. This interview study examines how older adults (age 65+) in two countries—the USA and India—experienced information needs, sources, and barriers. The results indicate distinct experiences among the two populations, with individuals in the USA expressing more diverse needs, while Indian respondents focused on the impact of COVID-19. The American respondents also indicated much greater use of Internet resources compared to the Indian respondents, who used television and print resources more frequently. Far more Indian respondents reported significant challenges finding information to satisfy their information needs. The findings of this study have important ramifications for the design of intervention, education, and support for the information-related needs of older adults worldwide.
The Challenge of Imposing Just Sentences Under Mandatory Minimum Statutes: A Qualitative Study of Judicial Perceptions
Authors: Nir Esther , Liu Siyu
Published: July 2021

Mandatory minimums limit judicial discretion in many jurisdictions in the United States, often compelling judges to impose harsh incarcerative terms. Using qualitative interviews with 41 criminal term judges presiding in a state in the United States, we explore how mandatory minimums influence the judicial sentencing function. We find that judges vary in their approaches to sentencing and that their approaches correspond with their perceptions of mandatory minimum statutes. While our respondents consider case-level, systemic, and pragmatic factors, the majority of judges are focused on the case level and perceive that mandatory minimums often strip away the flexibility they need to craft appropriate sentences in individual cases, leading to punishments that are unduly harsh, and sometimes preventing the imposition of promising alternatives to incarceration. Some judges experience moral dilemmas and guilt feelings during this process. In contrast, judges who highlight pragmatic factors (e.g., public perceptions) are more receptive to statutory restrictions.
Multiple performance characteristic index optimization of dimensional accuracy and geometrical shape angle in turn-mill multitasking machining
Authors: Huang Wei-Tai , Yang Shih-Cheng , Ho Wen-Hsien , Tsai Jinn-Tsong
Published: July 2021

Multiple performance objectives in turn-mill multitasking machining are investigated using the Taguchi method combined with the fuzzy theory. Using these two methods, optimized processing parameters can be rapidly identified to obtain optimized dimensional accuracy and geometrical shape angle, thus reducing machining cost and time. Herein, control factors for determining the single objective optimization parameter using the Taguchi robust process L9(34) orthogonal table were spindle speed (rpm), feed (mm/min), C-axis brake pressure (kg/cm2), axial cutting depth (mm), with dimensional accuracy and geometrical shape angle as objective characteristics. Then, signal-to-noise ratios of different groups were generated by gray correlation according to the experimental sequence to obtain the gray correlation coefficient for the calculation of the multiple performance characteristic index (MPCI). The MPCI results demonstrated that optimized dimensional accuracy was 0.005 mm and optimized geometrical shape angle was 0.004°. The optimized MPCI parameters were A3 (4000 rpm), B3 (250 mm/min), C3 (30 kg/cm2), and D3 (1.5 mm). It can reduce the processing for burr elimination and tool wear reduction by MPCI optimized process parameters.
Effects of Cloisite®20B inclusions on interlaminar fracture toughness of S-glass fiber-reinforced polymer composite
Authors: Woldemariam Mulugeta H , Belingardi Giovanni , Beyene Alem T , Reda Daniel T , Koricho Ermias G
Published: July 2021

Fiber reinforced plastic materials are able to be customized according to the application and behavior of materials. In this work, the effect of meticulous nanoclay, Cloisite 20B, inclusion (with various concentrations) on the interlaminar fracture toughness glass fiber reinforced plastic (GFRP) composite was experimentally investigated. The mode-I tests were conducted based on a double cantilever beam (DCB) tests using American society of testing materials (ASTM D5528). Results showed that the inclusion of nanoclays improved the interlaminar fracture toughness of the GFRP composite in the range of 12.65% and 54.07% relative to the pristine, with a progressive increment of the nanoclays weight by percentage content (from 0.5 to 2%). The research provides a better understanding of Cloisite filler's contribution in improvement of the delamination resistance and the outcome can guide to a design of better melt flow rate and good elongation at break of flame for structures, which is made up of composite materials.
Limits to and opportunities for scaling participation: lessons from three city-wide urban poor networks in Dhaka, Bangladesh
Authors: Cawood Sally
Published: July 2021

In Dhaka, three urban poor networks play a central role in advocating for the rights and entitlements of low-income settlement residents. Despite their numerous achievements, this article outlines how attempts to scale participation via these networks are limited by three overlapping state–civil society processes: (1) the politicization and increased monitoring of non-governmental organizations (NGOs); (2) shifting donor preferences towards service delivery and the creation of new community-based organizations (CBOs); and (3) the ongoing dominance and paternalism of NGOs towards low-income settlement residents. By situating these findings within existing understandings of in/formal governance and political participation, it can be argued that attempts to scale may struggle to evade or transform deep structures of dependency, patronage and intermediation. Recognizing that scaling can and does occur under these conditions, the article outlines opportunities to support the city-wide networks and alternative forms of organizing, to address pressing needs and priorities.
Analysis of parametric instability of a spring-attached pre-twisted beam with viscoelastic end support
Authors: Nayak Dipesh K , Pradhan Madhusmita , Jena Prabir K , Dash Pusparaj
Published: July 2021

This study investigated the parametric instability of a single elastic beam with spring attachment on the top and viscoelastic springs as end supports. The beam considered is pre-twisted with a pin connection at both ends that supports the beam. The analytical solution of the problem is expressed in the matrix form achieved from the implementation of Hamilton’s principle and General Galerkin’s method, from which both static and dynamic stability of the beam can be investigated. The results of various influential dimensionless parameters such as stiffness, mass, length, position of the spring attachment, and stiffness of the viscoelastic springs on both the stabilities are studied. This analysis concluded that the spring attachment on the system leads to substantial contribution in improving the stability. The viscoelastic springs also contribute in upsurging the beam’s stability. Three different profiles of the beam have been considered, and for each profile, three different types of springs have been examined. The results revealed that the beam with parabolic profile and stiffness of the spring attachment with parabolic variation is most effective towards strength-to-weight ratio.
10 Years of belimumab experience: What have we learnt?
Authors: Levy Roger A , Gonzalez-Rivera Tania , Khamashta Munther , Fox Norma Lynn , Jones-Leone Angela , Rubin Bernie , Burriss Susan W , Gairy Kerry , Maurik Andre van , Roth David A
Published: July 2021

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease affecting both adults and children. Belimumab is the only biologic approved for SLE, and the first in a class of drugs known as B-lymphocyte stimulator-specific inhibitors. The introduction of intravenous belimumab in 2011 was a major advance, being the first new therapy approved for SLE in over 50 years. As of April 2021, more than 7200 people with SLE have received belimumab in clinical studies, and it is approved in over 75 countries for the treatment of adults with SLE. A subcutaneous, self-injectable belimumab formulation was licensed in 2017 by both the US Food and Drug Administration (FDA) and European Medicines Agency (EMA). Belimumab was then approved for use in children in Europe, the USA and Japan in 2019, and China and Brazil in 2020. Recently, belimumab became the first FDA-approved drug for the treatment of adults with active lupus nephritis (LN), the most-common severe manifestation of SLE.

Over the past 10 years, belimumab has established its position as a disease modifier in the SLE treatment paradigms. Robust evidence from randomised clinical studies and observational, real-world studies has demonstrated the tolerability and efficacy of belimumab for reducing disease activity and the risk of new, severe SLE flares. This enables patients to taper their glucocorticoid use, which limits damage accumulation. Significantly more patients with active LN met the criteria for renal responses and were at less risk of a renal-related event or death after receiving belimumab plus standard therapy, compared with standard therapy on top of mandatory steroid reduction. Ongoing clinical studies are evaluating belimumab’s effectiveness in various indications beyond SLE. Post-marketing and registry studies are gathering additional data on key areas such as pregnancy outcomes after belimumab exposure and belimumab co-administration with other biologics.
Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling
Authors: Yang Xu , Huang Mei , Zhang Qin , Chen Jiao , Li Juan , Han Qian , Zhang Lu , Li JiaQi , Liu Shuai , Ma YuLan , Li Lan , Yang Lei , Zou SiYing , Han Bin
Published: July 2021

Background:

Ovarian cancer is the most lethal gynecological malignancy, and chemotherapy remains the cornerstone for ovarian cancer management. Due to the unsatisfactory prognosis, a better understanding of the underlying molecular carcinogenesis is urgently required.

Methods:

Assays for determining cell growth, cell motility, and apoptosis were employed to evaluate the potential antitumor effects of metformin against ovarian cancer cells. Molecular biological methods were employed to explore the underlying mechanism. Human ovarian cancer samples and Gene Expression Profiling Interactive Analysis (GEPIA) dataset were used for uncovering the clinical significances of mesothelin (MSLN) on ovarian cancer.

Results:

In the present work, we found that metformin treatment led to cell growth and cell migration inhibition, and induced cell apoptosis. Metformin administration also impaired cancer cell stemness and the capillary-like structure formation capacity of SKOV3 cells. On mechanism, metformin treatment remarkably reduced mesothelin (MSLN) expression, downregulated IL-6/STAT3 signaling activity, subsequently resulted in VEGF and TGFβ1 expression. We also observed an oncogenic function of MSLN on ovarian cancer.

Conclusions:

Collectively, our findings suggested that metformin exerts anticancer effects by suppressing ovarian cancer cell malignancy, which attributed to MSLN inhibition mediated IL6/STAT3 signaling and VEGF and TGFβ1 downregulation.
Calling nurses to care for burn victims after color-dust explosion
Authors: Tsai Yu-Lun , Yi Tin , Chiang Hsien-Hsien , Lan Hsiang-Yun , Chiang Hui-Hsun , Liaw Jen-Jiuan
Published: July 2021

Background:

Healthcare professionals follow codes of ethics, making them responsible for providing holistic care to all disaster victims. However, this often results in ethical dilemmas due to the need to provide rapid critical care while simultaneously attending to a complex spectrum of patient needs. These dilemmas can cause negative emotions to accumulate over time and impact physiological and psychological health, which can also threaten nurse–patient relationships.

Aim:

This study aimed to understand the experience of nurses who cared for burn victims of the color-dust explosion and the meaning of ethical relationships between nurse and patient.

Research design:

A qualitative descriptive study using a phenomenological approach.

Participants and research context:

Clinical nurses who provided care to the patients of the Formosa color-dust explosion of 2015 were selected by purposive sampling (N = 12) from a medical center in Taiwan. Data were collected using individual in-depth semi-structured interviews. Audiotaped interviews were transcribed and analyzed using Colaizzi’s method.

Ethical considerations:

This study was approved by the institutional review board of the study hospital. All participants provided written informed consent.

Findings

Three main themes described the essence of the ethical dilemmas experienced by nurses who cared for the burn-injured patients: (1) the calling must be answered, (2) the calling provoked my feelings, and (3) the calling called out my strengths.

Conclusions:

Healthcare providers should recognize that nurses believed they had an ethical responsibility to care for color-dust explosion burn victims. Understanding the feelings of nurses during the care of patients and encouraging them to differentiate between the self and the other by fostering patient–nurse relationships based on intersubjectivity could help nurses increase self-care and improve patient caregiving.
Theorizing Factors Mediating With the Implementation of a Patient Feedback on Safety Intervention Implemented in the Primary Care Setting
Authors: Beks Hannah , Hernan Andrea L. , Giles Sally , Malakellis Mary , Mc Namara Kevin P. , Versace Vincent L.
Published: July 2021

Developing safety interventions using patient feedback is valuable for creating safer systems of health care. A qualitative process evaluation of a patient feedback on safety intervention was undertaken in six primary care practices. The purpose was to theorize factors mediating with the implementation of the intervention using existing theories. The intervention required practices to obtain patient feedback on safety using a validated tool and respond using quality improvement methods. Multiple methods of qualitative data collection were used, including interviews and overt observation. Abductive reasoning informed the iterative process of analysis that examined theories relevant to the intervention and setting. A theoretical framework was developed, which encompassed mediating factors grouped under three concepts: practice readiness, utilization of problem-solving skills, and agency. Theorizing mediating factors was necessary to understand the complexities of primary care practices, and to identify the essential components for implementation of the intervention on a larger scale.
Familial Pfeiffer Syndrome: Variable Manifestations and Role of Multidisciplinary Team Care
Authors: Chaisrisawadisuk Sarut , Moore Mark H
Published: July 2021

Pfeiffer syndrome is one of the autosomal dominant craniofacial syndromes. Classical clinical manifestations are coronal suture synostosis causing brachycephaly, midface retrusion, airway compromise, broad thumbs, and toes. Pfeiffer syndrome type I (classic type) is associated with FGFR1 mutation. However, wide range of clinical manifestations, with and without craniosynostosis, have been reported. Here, we present a family of Pfeiffer syndrome across 3 generations with identical FGFR1: c.755C>G (p.Pro252Arg) mutation. Where the members of the youngest generation have no cranial involvement. Lastly, we propose a guideline management for familial Pfeiffer syndrome management.
Expert Consensus on the Development of a School-Based Intervention to Improve the School Participation and Connectedness of Elementary Students on the Autism Spectrum: A Delphi Study
Authors: Hodges Amy , Cordier Reinie , Joosten Annette , Bourke-Taylor Helen
Published: July 2021

School participation and connectedness have significant implications for student outcomes while at school and in later life. The need to develop evidence-based interventions to proactively support students with autism spectrum disorder (ASD) is imperative. A two-round Delphi technique was used to gain expert consensus to inform the development of a school-based intervention to improve the school participation and connectedness of elementary students with ASD. Seventy-six expert clinicians, educators, and researchers completed Round 1 and 65 completed Round 2. Consensus was achieved on the application of a conceptual framework of participation in Round 1, which informed the theoretical rationale of the intervention. Consensus on the importance of proposed classroom modules and the feasibility of proposed intervention techniques was achieved in Round 2. The process of gaining expert perspectives to develop an evidence-based intervention provides greater confidence that the intervention will be effective in achieving meaningful outcomes for students with ASD.
Clinical outcomes of the piggyback secondary implantation of a novel multifocal lens in the ciliary sulcus: A case series
Authors: Valvecchia Gerardo , Cervantes-Coste Guadalupe , Asis Oscar , Pereyra Federico , Garza-León Manuel , Gomez Caride Gastón , Ferlini Leonardo , Gonzalez-Salinas Roberto
Published: July 2021

Purpose:

Evaluate the clinical outcomes of the secondary piggyback add-on IOL implantation in the ciliary sulcus for pseudophakic patients previously implanted with a monofocal IOL, who pursue a spectacle-free option after IOL surgery.

Methods:

A prospective case series including seven pseudophakic patients who underwent an in-the-bag monofocal IOL implantation. All eyes underwent a piggyback IOL implantation of the new sulcus designed A4 AddOn IOL in the ciliary sulcus as a secondary procedure for pseudophakic patients pursuing a spectacle-free option for near and intermediate distance after IOL surgery.

Results:

Seven eyes from six patients were included in this study, from which 4 (71.43%) were female, with a mean age of 58.33 ± 3.5 years (range 54–63; 95% CI 54.66, 62.01). The postoperative spherical equivalent at the 3-month visit was −0.10 m ± 0.82. Also, the UDVA was 0.11 ± 0.08 logMAR, the UIVA 0.01 ± 0.03, and the UNVA 0.01 ± 0.03 3 months after their surgical procedure.

Conclusions:

The A4 AddOn multifocal IOL’s secondary piggyback implant is an efficient alternative for monofocal pseudophakic patients seeking presbyopia solutions. This sulcus-designed IOL provides an optimal visual outcome for near and distance vision.
Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study
Authors: Hartung Hans-Peter , Derfuss Tobias , Cree Bruce AC , Sormani Maria Pia , Selmaj Krzysztof , Stutters Jonathan , Prados Ferran , MacManus David , Schneble Hans-Martin , Lambert Estelle , Porchet Hervé , Glanzman Robert , Warne David , Curtin Francois , Kornmann Gabrielle , Buffet Bénédicte , Kremer David , Küry Patrick , Leppert David , Rückle Thomas , Barkhof Frederik
Published: July 2021

Background:

The envelope protein of human endogenous retrovirus W (HERV-W-Env) is expressed by macrophages and microglia, mediating axonal damage in chronic active MS lesions.

Objective and Methods:

This phase 2, double-blind, 48-week trial in relapsing-remitting MS with 48-week extension phase assessed the efficacy and safety of temelimab; a monoclonal antibody neutralizing HERV-W-Env. The primary endpoint was the reduction of cumulative gadolinium-enhancing T1-lesions in brain magnetic resonance imaging (MRI) scans at week 24. Additional endpoints included numbers of T2 and T1-hypointense lesions, magnetization transfer ratio, and brain atrophy. In total, 270 participants were randomized to receive monthly intravenous temelimab (6, 12, or 18 mg/kg) or placebo for 24 weeks; at week 24 placebo-treated participants were re-randomized to treatment groups.

Results:

The primary endpoint was not met. At week 48, participants treated with 18 mg/kg temelimab had fewer new T1-hypointense lesions ( p = 0.014) and showed consistent, however statistically non-significant, reductions in brain atrophy and magnetization transfer ratio decrease, as compared with the placebo/comparator group. These latter two trends were sustained over 96 weeks. No safety issues emerged.

Conclusion:

Temelimab failed to show an effect on features of acute inflammation but demonstrated preliminary radiological signs of possible anti-neurodegenerative effects. Current data support the development of temelimab for progressive MS.

Trial registration:

CHANGE-MS: ClinicalTrials.gov: NCT02782858, EudraCT: 2015-004059-29; ANGEL-MS: ClinicalTrials.gov: NCT03239860, EudraCT: 2016-004935-18
Causal attributions and perceived stigma for myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Froehlich Laura , Hattesohl Daniel BR , Cotler Joseph , Jason Leonard A , Scheibenbogen Carmen , Behrends Uta
Published: July 2021

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disease with the hallmark symptom of post-exertional malaise. Evidence for physiological causes is converging, however, currently no diagnostic test or biomarker is available. People with ME/CFS experience stigmatization, including the perception that the disease is psychosomatic. In a sample of 499 participants with self-diagnosed ME/CFS, we investigated perceived stigma as a pathway through which perceived others’ causal attributions relate to lower satisfaction with social roles and activities and functional status. Higher perceived attributions by others to controllable and unstable causes predicted lower health-related and social outcomes via higher perceived stigma.
Media, mortality and necro-technologies: Eulogies for dead media
Authors: Nansen Bjørn , Gould Hannah , Arnold Michael , Gibbs Martin
Published: July 2021

Working at the intersection of death studies and media studies, this article examines what we can learn from the death of media technologies designed for the deceased, what we refer to as necro-technologies. Media deaths illuminate a tension between the promise of persistence and realities of precariousness embodied in all media. This tension is, however, more visibly strained by the mortality of technologies designed to mediate and memorialise the human dead by making explicit the limitations of digital eternity implied by products in the funeral industry. In this article, we historicise and define necro-technologies within broader discussions of media obsolescence and death. Drawing from our funeral industry fieldwork, we then provide four examples of recently deceased necro-technologies that are presented in the form of eulogies. These eulogies offer a stylised but culturally significant format of remembrance to create an historical record of the deceased and their life. These necro-technologies are the funeral attendance robot CARL, the in-coffin sound system CataCombo, the posthumous messaging service DeadSocial and the digital avatar service Virtual Eternity. We consider what is at stake when technologies designed to enliven the human deceased – often in perpetuity – are themselves subject to mortality. We suggest a number of entangled economic, cultural and technical reasons for the failure of necro-technologies within the specific contexts of the death care industry, which may also help to highlight broader forces of mortality affecting all media technologies. These are described as misplaced commercial imaginaries, cultural reticence and material impermanence. In thinking about the deaths of necro-technologies, and their causes, we propose a new form of death, a ‘material death’ that extends beyond biological, social and memorial forms of human death already established to account for the finitude of media materiality and memory.
Renegotiating the public good: Responding to the first wave of COVID-19 in England, Germany and Italy
Authors: Kelly Peter , Hofbauer Susann , Gross Barbara
Published: July 2021

We compare national education policy responses to the COVID-19 pandemic in England, Germany and Italy to explore negotiations about the public good and identify the role that research has played in framing, legitimating and rendering trustworthy the settlements reached. National data, comprising news media reports and publically available documents, are analysed and compared to identify debates about the public good and their consequences within and across national contexts. Our analysis contrasts policy contexts on three dimensions: (a) the range of interests included in debates; (b) the form and locus of decision-making; and (c) public acceptance of policy during implementation. These are related to processes of depoliticising debate and politicising research evidence in each context, as factions position themselves as trustworthy. We suggest that the way research is seen to inform decision-making during crises such as the current COVID-19 pandemic has enduring consequences for public trust in research, the politicians who employ it to justify their decisions and the schools tasked with putting these decisions into practice.
Visual Analysis Plus Hierarchical Linear Model Regressions: Morphosyntax Intervention with Deaf-and-Hard-of-Hearing Students
Authors: Hasko Janna , Rivera M. Christina , Erbacher Monica K. , Antia Shirin D.
Published: July 2021

We conducted a pilot study using intentional teaching strategies with specially designed materials to improve accuracy and production of targeted English morphosyntax structures with six deaf and hard-of-hearing students (kindergarten to first grade). A multiple baseline single-case research design (SCRD) consisting of 20-minute sessions four times per week for the duration of a school year was implemented to determine the effect of the supplemental syntax curriculum. The data were inconsistent and highly variable. Visual analyses were problematic; therefore, hierarchical linear model (HLM) regression analyses were conducted with the time series SCRD data as an additional analysis. HLM regression analyses were used to interpret data that might otherwise be overlooked in SCRDs to provide specific values for the rate students were learning during the intervention phase of the study. This pilot study demonstrates that the syntax intervention produces promising results when data that are too messy for visual analysis are analyzed with HLM.
Investigation of 18F and 89Zr Isotopes Self-Absorption and Dose Rate Parameters for PET Imaging
Authors: Alfuraih Abdulrahman A. , Alzimami Khalid , Ma Andy K.
Published: July 2021

This work concerns study of self-absorption factor (SAF) and dose rate constants of zirconium-89 (89Zr) for the purpose of radiation protection in positron emission tomography (PET) and to compare them with those of 18F-deoxyglucose (18F-FDG). We analyzed the emitted energy spectra by 18F and 89Zr through anthropomorphic phantom and calculated the absorbed energy using Monte Carlo method. The dose rate constants for both radionuclides were estimated with 2 different fluence-to-effective dose conversion coefficients. Our estimated SAF value of 0.65 for 18F agreed with the recommendation of the American Association of Physicists in Medicine (AAPM). The SAF for 89Zr was in the range of 0.61-0.66 depending on the biodistribution. Using the fluence-to-effective dose conversion coefficients recommended jointly by the American National Standards Institute and the American Nuclear Society (ANSI/ANS), the dose rate at 1 m from the patient for 18F was 0.143 μSv·MBq−1·hr−1, which is consistent with the AAPM recommendation, while that for 89Zr was 0.154 μSv·MBq−1·hr−1. With the conversion coefficients currently recommended by the International Committee on Radiological Protection (ICRP), the dose rate estimates were lowered by 2.8% and 2.6% for 89Zr and 18F, respectively. Also, we observed that the AAPM derived dose is an overestimation near the patient, compared to our simulations, which can be explained by the biodistribution nature and the assumption of the point source. Thus, we proposed new radiation protection factors for 89Zr radionuclide.
Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system
Authors: How Shing Koy Elsa , Labauge Pierre , Baillet Athan , Prati Clément , Marotte Hubert , Pers Yves-Marie
Published: July 2021

Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient’s comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokines is worth investigating in these neuropsychiatric diseases. This review aimed to explore the role of TNF-α and IL-17 in the pathogenesis of uveitis, multiple sclerosis, neuromyelitis optica, Alzheimer’s disease, Parkinson’s disease and depression. This update is critical to guide the therapeutic management of these co-morbidities in SpA patients.