bluuebunny/crossref_metadata_2025 huggingface dataset:
CIGB-300 peptide targets the CK2 phospho-acceptor domain on Human Papillomavirus E7 and disrupts the Retinoblastoma (RB) complex in cervical cancer cells
Authors: Ramón Ailyn C. , Basukala Om , Massimi Paola , Thomas Miranda , Perera Yasser , Banks Lawrence , Perea Silvio E.
Published: June 2022

CIGB-300 is a clinical-grade anti- Protein Kinase CK2 peptide, binding both its substrate’s phospho-acceptor site and the CK2α catalytic subunit. The cyclic p15 inhibitory domain of CIGB-300 was initially selected in a phage display library screen for its ability to bind the CK2 phospho-acceptor domain of HPV-16 E7. However, the actual role of this targeting in CIGB-300’s antitumoral mechanism remains unexplored. Here, we investigated the physical interaction of CIGB-300 with HPV-E7 and its impact on CK2-mediated phosphorylation. Hence, we studied the relevance of targeting E7 phosphorylation for the cytotoxic effect induced by CIGB-300. Finally, co-immunoprecipitation experiments followed by western blot were performed to study the impact of the peptide on the E7-pRB interaction. Interestingly, we found a clear binding of CIGB-300 to the N terminal region of E7 proteins from HPV-16 type. Accordingly, the in vivo physical interaction of the peptide with HPV-16 E7 reduces the CK2-mediated phosphorylation of E7, as well as its binding to the tumour suppressor pRB. However, the targeting of E7 phosphorylation by CIGB-300 seemed to be dispensable for the induction of cell death in HPV-18 cervical cancer-derived C4-1 cells. These findings unveil novel molecular clues to the means by which the CIGB-300 triggers cell death in cervical cancer cells.
Toxicity of House Cricket (Acheta domesticus) in Mice
Authors: Yasuki Matano , Kiyo Sakagami , Yuuto Nojiri , Kenta Nomura , Akira Masuda , Yuuki Moriike , Akane Yamamoto , Nobuo Nagai , Atsushi Ogura
Published: June 2022

There is an urgent need to address the shortage of animal protein due to food shortages caused by the global population growth. Crickets contain an abundance of proteins in their exoskeleton and muscles and have attracted attention as a new protein source; however, their safety as a food source has not been confirmed. We evaluated the toxicity of the House cricket (Acheta domesticus), on cells and mammals. In genotoxicity in vitro, cricket powder was added to Chinese hamster lung CHL-IU cells at concentrations of 5,000 µg/mL, and the rate of chromosomal aberrations was assessed. In genotoxicity in vivo, mice were orally administered up to 2,000 mg/kg of cricket powder for 2 days. In both tests, cricket powder did not show any toxic effect. A repeated oral toxicity study was performed administering up to 3,000 mg/kg of cricket powder or control (saline) for 14 or 90 consecutive days and measuring body weight changes, blood biochemistry, blood properties, and organ weights. In each time course, there were no differences in there parameters between the control and cricket powder treated groups. These results suggest that House crickets (≤3,000 mg/kg) are not toxic to cells and organisms.
Verkko: telomere-to-telomere assembly of diploid chromosomes
Authors: Rautiainen Mikko , Nurk Sergey , Walenz Brian P. , Logsdon Glennis A. , Porubsky David , Rhie Arang , Eichler Evan E. , Phillippy Adam M. , Koren Sergey
Published: June 2022

The Telomere-to-Telomere consortium recently assembled the first truly complete sequence of a human genome. To resolve the most complex repeats, this project relied on manual integration of ultra-long Oxford Nanopore sequencing reads with a high-resolution assembly graph built from long, accurate PacBio HiFi reads. We have improved and automated this strategy in Verkko, an iterative, graph-based pipeline for assembling complete, diploid genomes. Verkko begins with a multiplex de Bruijn graph built from long, accurate reads and progressively simplifies this graph via the integration of ultra-long reads and haplotype-specific markers. The result is a phased, diploid assembly of both haplotypes, with many chromosomes automatically assembled from telomere to telomere. Running Verkko on the HG002 human genome resulted in 20 of 46 diploid chromosomes assembled without gaps at 99.9997% accuracy. The complete assembly of diploid genomes is a critical step towards the construction of comprehensive pangenome databases and chromosome-scale comparative genomics.
The impact of the COVID-19 pandemic on the nexus between the investor’s sentiment and the financial market dynamics: evidence from the Chinese market
Authors: Soltani Hayet , Boujelbene Abbes Mouna
Published: June 2022

Purpose

This study aims to investigate the impact of the COVID-19 pandemic on both of stock prices and investor's sentiment in China during the onset of the COVID-19 crisis.

Design/methodology/approach

In this study, the ADCC-GARCH model was used to analyze the asymmetric volatility and the time-varying conditional correlation among the Chinese stock market, the investors' sentiment and its variation. The authors relied on Diebold and Yilmaz (2012, 2014) methodology to construct network-associated measures. Then, the wavelet coherence model was applied to explore the co-movements between these variables. To check the robustness of the study results, the authors referred to the RavenPack COVID sentiments and the Chinese VIX, as other measures of the investor's sentiment using daily data from December 2019 to December 2021.

Findings

Using the ADCC-GARCH model, a strong co-movement was found between the investor's sentiment and the Shanghai index returns during the COVID-19 pandemic. The study results provide a significant peak of connectivity between the investor's sentiment and the Chinese stock market return during the 2015–2016 and the end of 2019–2020 turmoil periods. These periods coincide, respectively, with the 2015 Chinese economy recession and the COVID-19 pandemic outbreak. Furthermore, the wavelet coherence analysis confirms the ADCC results, which revealed that the used proxies of the investor's sentiment can detect the Chinese investors' behavior especially during the health crisis.

Practical implications

This study provides two main types of implications: on the one hand, for investors since it helps them to understand the economic outlook and accordingly design their portfolio strategy and allocate decisions to optimize their portfolios. On the other hand, for portfolios managers, who should pay attention to the volatility spillovers between investor sentiment and the Chinese stock market to predict the financial market dynamics during crises periods and hedge their portfolios.

Originality/value

This study attempted to examine the time-varying interactions between the investor's sentiment proxies and the stock market dynamics. Findings showed that the investor's sentiment is considered a prominent channel of shock spillovers during the COVID-19 crisis, which typically confirms the behavioral contagion theory.
Healing fields foundation: the challenge faced in “effectually” covering the proverbial last mile
Authors: Ahmed Nadeem , Kuzhikkat Prabath
Published: June 2022

Study level/applicability

This case study can be used at the graduate and executive levels.

Subject area

This case study can be used in entrepreneurship, leadership, social entrepreneurship and human resource management.

Case overview

Healing Fields Foundation is a non-governmental organisation (NGO) that was co-founded by Mukti Bosco to create an affordable and quality health-care ecosystem, primarily through women. The pragmatism of Mukti and her strong alignment with the core values of the foundation ensured that they emerged unscathed from past challenges. During the second wave of the pandemic in 2021, they employed bikers on a contractual basis to satisfy last-mile delivery demand in rural India. However, owing to the recovery post the second wave, the demand for their services dropped and subsequently their earnings. Being provided with four options by her COO, Mukti is cognisant of the social implications her decisions will have on all the stakeholders in the ecosystem.

Expected learning outcomes

A. Identify and prioritise key stakeholders of the organisation for effective decision-making. B. Differentiate effectual from causal reasoning and apply their right balance while making decisions. C. Delineate social entrepreneurs from their for-profit, non-mission-driven counterparts. D. Create value for the organisation’s stakeholders through the management of its diverse workforce. E. Formulate entrepreneurial solutions through the application of relevant concepts and frameworks.

Subject code

CSS 3: Entrepreneurship.
Relationship networks between variation orders and claims/disputes causes on construction project performance and stakeholder performance
Authors: Do Sy Tien , Nguyen Viet Thanh , Nguyen Nghia Hoai
Published: June 2022

Purpose

This study aims to examine the mutual influence of causes of variation orders (VOs), claims/disputes (CDs) on project performance (PP) and stakeholder performance (SP).

Design/methodology/approach

Firstly, this study identifies the VOs, the CDs, criteria for measuring the PP and criteria for measuring the SP. Then, a survey questionnaire is created to collect data from stakeholders in construction projects. Using the factor analysis method, this study discovers the constructs of the VOs, CDs, PP and SP. The relationships among the constructs are then uncovered using a structural equation model.

Findings

The research findings confirm that the VOs and CDs have a direct effect on the PP, as well as the PP’s effect on SP, whereas the VOs and CDs have no effect on the SP. It is strongly recommended that critical factors such as poor management, construction method change, design/scope problems, uncontrollable objective problems, impediment problems, lack of commitment among parties and lack of experience and competence of parties should be given special attention to improve the SP.

Originality/value

The results of the study fill the gap in knowledge by examining the mutual influence of the VOs, the CDs, the PP and the SP. Discovering the mutual influence will assist managers in improving the PP and the SP.
Supply chain analytics and post-pandemic performance: mediating role of triple-A supply chain strategies
Authors: Khan Syed Abdul Rehman , Piprani Arsalan Zahid , Yu Zhang
Published: June 2022

Purpose

The abrupt outbreak of coronavirus disease (COVID-19) hit every nation in 2020–2021, causing a worldwide pandemic. The worldwide COVID-19 epidemic, described as a “black swan”, has severely disrupted manufacturing firms' supply chain. The purpose of this study is to investigate how supply chain data analytics enable the effective deployment of agility, adaptability and alignment (3As) strategies, resulting in improving post-COVID disruption performance. It also analyses the indirect effect of supply chain data analytics on disruption performance through the 3As supply chain strategies.

Design/methodology/approach

The hypothesis and theoretical framework were tested using a questionnaire survey. The authors employed structural equation modelling through the SMART PLS version 3.2.7 to analyse data from 163 textile firms located in Pakistan.

Findings

The results revealed that the supply chain data analytics contributed positively and significantly to the agility and adaptability, while all 3As supply chain strategies impacted the PPERF substantially. Further, the connection between supply chain data analytics (SCDA) and disruption performance has substantially been influenced through 3As supply chain strategies.

Practical implications

The results imply that in the event of low likelihood, high effect disruptions, managers and decision-makers should focus their efforts on integrating data analytics capabilities with 3As supply chain policies to ensure long-term company success.

Originality/value

This research sheds fresh light on the importance of data analytics in effectively implementing 3As strategies for sustaining company performance amid COVID-19 disruptions.
Congruity or dispel? A segmented bibliometric analysis of Sukuk structures
Authors: Nasir Adeel , Farooq Umar , Khan Kanwal Iqbal , Khan Ather Azim
Published: June 2022

Purpose

This study aims to explain the Sukuk structures individually by highlighting the key differences and commonalities in their influential aspects. It also compares the core aspects of Sukuk literature with conventional bonds and suggests the point of differences between them.

Design/methodology/approach

This study uses a quali-quantitative approach with the help of segmented bibliometric analysis to describe core differences and commonalities in various Sukuk structures in terms of core authors, countries, sources, affiliation, documents and keywords. In addition, it deploys “biblioshiny” from R-package “bibliometrix 3.0” to identify key influential aspects of different Sukuk instruments.

Findings

Results reported that Malaysia is the core contributing country in Sukuk publications and the center of author correspondence. There is a structural difference among various Sukuk instruments. The significant literature commonalities in Ijarah, Mudarabah, Musharakah and Murabahah Sukuk affiliations and globally cited journal articles are also found. However, the influential aspects of Sukuk compared with conventional bonds are different from other Sukuk literature. It also conducted a keyword analysis to report significant themes in the literature.

Originality/value

This study contributes to the existing body of knowledge as it helps investors to understand the shariah permissibility and investment supremacy of various Sukuk alternatives. Investors, policymakers, scholars and researchers should understand the dynamics of multiple Sukuk structures and their Shari’ah permissibility. This study significantly elaborates on this objective.
The effectiveness of the auditor’s opinion on the internal controls over financial reporting
Authors: Radu Camélia , Segalin Zanella Aline
Published: June 2022

Purpose

Recent studies have concluded that auditors underreport existing internal control over financial reporting (ICFR) weaknesses. This study aims to assess how effective external auditors are, as independent third parties, at disclosing reliable opinions to the public on the ICFR.

Design/methodology/approach

Using a logistic regression, the authors analyzed a sample of 106 US companies classified as large accelerated filers or accelerated filers consisting in 53 companies which restated their financial statements and a control group of 53 companies having “clean financial statements” at any given moment during the research period, between 2005 and 2018.

Findings

The results indicate that only 34% of companies with financial statements deemed unreliable have received an adverse ICFR opinion issued by the external auditor during the misrepresentation period or its prior year. The authors also notice that external auditors are somewhat effective in identifying and disclosing red flags to the public that certain companies have internal control (IC) material weaknesses. The results also indicate that the average presence of an adverse IC opinion issued by the external auditor during the misrepresentation period or its prior year for companies with unreliable financial statements is higher than for companies with financial statements deemed reliable.

Practical implications

This study tests if an increase in efforts and disbursements with audit fees are justifiable by external auditors’ issuing effective, reliable opinions and reinforcing a more transparent and ethical capital markets environment, that is, an environment where accurate information is available for stakeholders. If external auditors are negligent in providing a qualitative and independent opinion to stakeholders, the increase of disbursements made with audit fees is less justifiable. Thus, the research has practical implication for auditors as well as standard setters.

Originality/value

This study extends the literature on ICFR by empirically testing whether the public can rely on external auditors’ opinions expressed on Sarbanes–Oxley Section 404 reports.
SOTIF risk mitigation based on unified ODD monitoring for autonomous vehicles
Authors: Yu Wenhao , Li Jun , Peng Li-Ming , Xiong Xiong , Yang Kai , Wang Hong
Published: June 2022

Purpose

The purpose of this paper is to design a unified operational design domain (ODD) monitoring framework for mitigating Safety of the Intended Functionality (SOTIF) risks triggered by vehicles exceeding ODD boundaries in complex traffic scenarios.

Design/methodology/approach

A unified model of ODD monitoring is constructed, which consists of three modules: weather condition monitoring for unusual weather conditions, such as rain, snow and fog; vehicle behavior monitoring for abnormal vehicle behavior, such as traffic rule violations; and road condition monitoring for abnormal road conditions, such as road defects, unexpected obstacles and slippery roads. Additionally, the applications of the proposed unified ODD monitoring framework are demonstrated. The practicability and effectiveness of the proposed unified ODD monitoring framework for mitigating SOTIF risk are verified in the applications.

Findings

First, the application of weather condition monitoring demonstrates that the autonomous vehicle can make a safe decision based on the performance degradation of Lidar on rainy days using the proposed monitoring framework. Second, the application of vehicle behavior monitoring demonstrates that the autonomous vehicle can properly adhere to traffic rules using the proposed monitoring framework. Third, the application of road condition monitoring demonstrates that the proposed unified ODD monitoring framework enables the ego vehicle to successfully monitor and avoid road defects.

Originality/value

The value of this paper is that the proposed unified ODD monitoring framework establishes a new foundation for monitoring and mitigating SOTIF risks in complex traffic environments.
A framework for assessment of critical factor for circular economy practice implementation
Authors: Singh Rubee , Khan Shahbaz , Dsilva Jacinta
Published: June 2022

Purpose

Consumers, governments and regulatory agencies are concerned about the social and environmental aspect that pushes firms to move towards the circular economy. The transformation of the existing linear model into a circular model depends on several circular economy practices. Therefore, the purpose of this study is to identify and analyse the critical factors that are responsible for the adoption of circular practices.

Design/methodology/approach

In total, 15 critical factors are identified through the literature review and 12 are finalised with the grey Delphi method. Further, these critical factors are prioritised using the weighted aggregated sum/product assessment (WASPAS) method. A sensitivity analysis is also conducted to test the robustness of the ranking of critical factors obtained from WASPAS.

Findings

The finding of this study show that “top management participation,” “market for recovered products” and “circular economy oriented R&D activities promotion” are the most significant factors for circular practice adoption. These factors need to address on the highest priority by the stakeholders.

Research limitations/implications

This study is beneficial for the managers to formulate their strategies for the adoption of circular practices. The prioritisation of critical factors supports the managers and professionals to optimise their effort and resources to adopt the circular practice.

Originality/value

This study explores and analyses the critical factor for circular economy practice adoption in the supply chain in the context of emerging economies.
Determinants of Facebook adoption and its impact on service-based small and medium enterprise performance in northwestern Nigeria
Authors: Abdullahi Idris Na’umma , Husin Mohd Heikal , Baharudin Ahmad Suhaimi , Abdullah Nor Athiyah
Published: June 2022

Purpose

This study aims to examine the determinants of Facebook adoption and its impact on the performance of service-based small and medium enterprises (SMEs) in northwestern Nigeria. The mediating effect of Facebook adoption between the determinants of Facebook adoption and the performance of the SMEs was examined.

Design/methodology/approach

A comprehensive framework was built using the technology – organisation–environment framework integrated with the resource-based view theory. Data were collected from 165 SME decision-makers using an online survey. The hypothesised relationships were tested using partial least squares structural equation modelling.

Findings

Facebook adoption exerted a positive impact on the financial and non-financial performance of the SMEs. The important determinants of Facebook adoption were relative advantage, perceived risks, top management support, organisational readiness and government support. The mediating effect of Facebook adoption between these determinants and financial and non-financial performance was confirmed.

Research limitations/implications

The findings contribute to better insight into the determinants of Facebook adoption and its impact on the financial and non-financial performance of SMEs. The findings can inspire and guide SMEs on adopting Facebook as a marketing strategy to improve performance and reduce failure rates.

Originality/value

The findings confirm the potential of adopting Facebook for enhancing the performance of SMEs. This is arguably among the first empirical studies to test the mediating effect of Facebook adoption.
The dyadic utility space and the interaction – utility matrix: how individual goal-setting determines realizable utilities in dyadic relations
Authors: Nechansky Helmut
Published: June 2022

Purpose

The paper analyzes how the goal-setting of two individuals or social units A and B determines the utilities, which the two parties can gain in a dyadic interaction.

Design/methodology/approach

The analysis is based on a dyadic utility space representing the utilities of A and B along the x and y axis, respectively. In this space the goal-orientation of an individual action is mapped with a vector, where its angle shows the combination of utilities of A and B aimed at, and the length corresponds to the strength of an action.

Findings

Analyzing actions of A and responses of B in the dyadic utility space allows (a) calculating single and joint utilities, (b) identifying the narrow range of equal utility for both and (c) identifying four vectors for maximizing different combinations of utility. Studying combinations of these four vectors in a 4 × 4 ‘Interaction - Utility Matrix’ shows how the goal-setting of A for a prime action widely predetermines, before a response of B, the realizable dyadic utility for both.

Practical implications

The dyadic utility space allows illustrating any dyadic interaction: It shows all possible dyadic “payoffs” investigated in game theory; it allows studying repeated exchange and resulting accumulation of utility; it allows mapping power relations.

Originality/value

The paper shows the interrelation between cybernetic principles of control, goal-orientated human behavior and the utility concept of social sciences. And it allows rejecting Adam Smith’s 18th myth of an “invisible hand”.
A production and inventory model for deteriorating items with two-level partial trade credit and stochastic demand in a supply chain
Authors: Dai Zhuo , Wang Yiju
Published: June 2022

Purpose

The purpose of this paper is to maximize the average profit of the supply chain by calculating the order quantity, the number of shipments during the production time of the vendor, the number of shipments during the supply cycle of the vendor and the time when the retailer’s inventory level reaches to zero.

Design/methodology/approach

A production and inventory model for degrading commodities with stochastic demand and two-level partial trade credit in a supply chain is presented. The model’s applicability and the processes' feasibility for solving are verified by GAMS software with BARON.

Findings

The impact of the model’s parameters on the vendor and retailer’s average profit was found through sensitivity analysis. The effect of the model’s parameters on the supply chain’s average profit was also found. Moreover, the reasons for this effect were given.

Practical implications

First, decision-makers may use this model to increase the supply chain's average profit. Second, the proposed model takes a general form. Third, the policymakers can also adjust the model’s parameters according to their preferences to get the desired results.

Originality/value

First, this paper develops an inventory and production model for perishable goods. Second, it is believed that the demand is random because the demand is affected by many factors, which make the study more realistic. Third, this paper studies production and inventory problems from the supply chain perspective. Finally, the interest for partial trade credit is calculated. The interest caused by stochastic shortages is also considered and calculated.
A reflection on the development and delivery of a community peer support service for clients experiencing anxiety and depression
Authors: Lidbetter Nicky , Seccombe Nic , Rogers Ember Girling , Lee Tina
Published: June 2022

Purpose

The purpose of this paper is to describe the development, implementation, delivery and evolution of a community-led, comprehensive, peer support service, including co-production approaches, peer support worker role development, outcomes, acceptability and lessons learnt over a five-year timeframe.

Design/methodology/approach

This case study presents a reflection on a charity’s peer support service development along with outcomes to highlight client progress.

Findings

Improvement in well-being as measured through the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) was evidenced along with demonstrating that the peer support service offers complementary support to Improving Access to Psychological Therapies (IAPT) services.

Research limitations/implications

There was limited quantitative data, and that which existed was analysed on a service-wide basis as opposed to looking at individual components of the service.

Practical implications

This paper demonstrates the value of peer support provision as part of an overall primary care, community-based mental health service, including findings that suggest that for some individuals, where IAPT services did not help them as much, a peer-based service appeared to be more suitable.

Social implications

The peer support service provided a complementary and alternative service to conventional primary care mental health services whilst offering individuals with lived experience to gain volunteering, employment and development opportunities.

Originality/value

Whilst peer support services have been well documented in the literature for clients experiencing serious mental illness, research on the use of such approaches in the management of common mental health difficulties including anxiety and depression is not as well established. The aim of this paper is to detail the experiences of a user-led charity in developing and delivering peer support services, including challenges encountered. Furthermore, this paper describes a peer support service that has been integrated with a co-existing low intensity IAPT service, reporting recovery rates for clients that have accessed both peer support and IAPT services.
The making of box-office collection: qualitative insights from Bollywood
Authors: Patil Vijaya , Date Hema , Kumar Satish , Lim Weng Marc , Donthu Naveen
Published: June 2022

Purpose

This study explores the making of box-office collection using the Indian film industry, Bollywood, as a case.

Design/methodology/approach

This study conducts in-depth interviews with cinematic experts in the Indian film industry and analyzes the interview transcripts using thematic analysis.

Findings

This study uncovers several noteworthy findings. First, films that drew both general (MASS audience) and niche (CLASS audience) viewers dominate the box office. Second, viewers prefer to see films that are based on true events, and their engagement will be deeper if the subject of the film resonates with them. Third, stakeholder share is variable and changes over time. Fourth, the marketing budget for a film is typically higher than its production budget, and it is determined by the producer's financial resources. Fifth, the dominance of big over small banner films motivates the latter to pursue online rather than cinematic releases. Finally, Internet access creates value and returns on investment through sales of satellite and musical rights, while strategic promotion and distribution reap maximum benefit for box-office collection.

Originality/value

Unlike past studies that rely on secondary data, this study uses primary qualitative data to explore the making of box-office collection. This study also focuses on an alternative film industry, Bollywood, as it is a vast context that remains underexplored.
Examining the mass loss and thermal properties of 3D printed models produced by fused deposition modeling and stereolithography under elevated temperatures
Authors: Hsieh Shu-An , Anderson Jared L.
Published: June 2022

Purpose

This paper aims to study the mass loss of three-dimensional (3D) printed materials at high temperatures. A preconcentration and analysis technique, static headspace gas chromatography-mass spectrometry (SHS-GC-MS), is demonstrated for the analysis of volatile compounds liberated from fused deposition modeling (FDM) and stereolithography (SLA) 3D printed models under elevated temperatures.

Design/methodology/approach

A total of seven commercial 3D printing materials were tested using the SHS-GC-MS approach. The printed model mass and mass loss were examined as a function of FDM printing parameters including printcore temperature, model size and printing speed, and the use of SLA postprocessing procedures. A high temperature resin was used to demonstrate that thermal degradation products can be identified when the model is incubated under high temperatures.

Findings

At higher printing temperatures and larger model sizes, the initial printed model mass increased and showed more significant mass loss after thermal incubation for FDM models. For models produced by SLA, the implementation of a postprocessing procedure reduced the mass loss at elevated temperatures. All FDM models showed severe structural deformation when exposed to high temperatures, while SLA models remained structurally intact. Mass spectra and chromatographic retention times acquired from the high temperature resin facilitated identification of eight compounds (monomers, crosslinkers and several photoinitiators) liberated from the resin.

Originality/value

The study exploits the high sensitivity of SHS-GC-MS to identify thermal degradation products emitted from 3D printed models under elevated temperatures. The results will aid in choosing appropriate filament/resin materials and printing mechanisms for applications that require elevated temperatures.
Process window identification for 3D printing low melting point alloy (LMPA) using fused deposition modelling (FDM)
Authors: Parvanda Rishi , Kala Prateek
Published: June 2022

Purpose

Fused deposition modelling (FDM) has gained popularity owing to its capability of producing complex and customized profiles at relatively low cost and in shorter periods. The study aims to extend the use of FDM printers for 3D printing of low melting point alloy (LMPA), which has applications in the electronics industry, rapid tooling, biomedical, etc.

Design/methodology/approach

Solder is the LMPA with alloy’s melting temperature (around 200°C) lower than the parent metals. The most common composition of the solder, which is widely used, is tin and lead. However, lead is a hazardous material having environmental and health deteriorating effects. Therefore, lead-free Sn89Bi10Cu non-eutectic alloy in the form of filament was used. The step-by-step method has been used to identify the process window for temperature, print speed, filament length (E) and layer height. The existing FDM printer was customized for the present work.

Findings

Analysis of infrared images has been done to understand discontinuity at a certain range of process parameters. The effect of printing parameters on inter-bonding, width and thickness of the layers has also been studied. The microstructure of the parent material and deposited bead has been observed. Conclusions were drawn out based on the results, and the scope for the future has been pointed out.

Originality/value

The experiments resulted in the process window identification of print speed, extrusion temperature, filament length and layer height of Sn89Bi10Cu which is not done previously.
Differential Thermal Regimes of the Tarim and Sichuan Basins in China: Implications for Hydrocarbon Generation and Conservation
Authors: CHANG Jian , LI Dan , QIU Nansheng , ZHU Chuanqing , ZHONG Ningning , FENG Qianqian , ZHANG Haizu , WANG Xiang
Published: June 2022

The uncertainty surrounding the thermal regimes of the ultra‐deep strata in the Tarim and Sichuan basins, China, is unfavorable for further hydrocarbon exploration. This study summarizes and contrasts the present‐day and paleo heat flow, geothermal gradient and deep formation temperatures of the Tarim and Sichuan basins. The average heat flow of the Tarim and Sichuan basins are 42.5 ± 7.6 mW/m2 and 53.8 ± 7.6 mW/m2, respectively, reflecting the characteristics of ‘cold’ and ‘warm’ basins. The geothermal gradient with unified depths of 0–5,000 m, 0–6,000 m and 0–7,000 m in the Tarim Basin are 21.6 ± 2.9 °C/km, 20.5 ± 2.8 °C/km and 19.6 ± 2.8 °C/km, respectively, while the geothermal gradient with unified depths of 0–5,000 m, 0–6,000m and 0–7,000 m in the Sichuan Basin are 21.9 ± 2.3 °C/km, 22.1 ± 2.5 °C/km and 23.3 ± 2.4 °C/km, respectively. The differential change of the geothermal gradient between the Tarim and Sichuan basins with depth probably results from the rock thermal conductivity and heat production rate. The formation temperatures at depths of 6,000 m, 7,000 m, 8,000 m, 9,000 m and 10,000 m in the Tarim Basin are 80°C–190°C, 90°C–220°C, 100°C–230°C, 110°C–240°C and 120°C–250°C, respectively, while the formation temperatures at depths of 6,000 m, 7,000 m, 8,000 m and 9,000 m in the Sichuan Basin are 120°C–200°C, 140°C–210°C, 160°C–260°C and 180°C–280°C, respectively. The horizontal distribution pattern of the ultra‐deep formation temperatures in the Tarim and Sichuan basins is mainly affected by the basement relief, fault activity and hydrothermal upwelling. The thermal modeling revealed that the paleo‐heat flow in the interior of the Tarim Basin decreased since the early Cambrian with an early Permian abrupt peak, while that in the Sichuan Basin experienced three stages of steady state from Cambrian to early Permian, rapidly rising at the end of the early Permian and declining since the late Permian. The thermal regime of the Sichuan Basin was always higher than that of the Tarim Basin, which results in differential oil and gas generation and conservation in the ultra‐deep ancient strata. This study not only promotes theoretical development in the exploration of ultra‐deep geothermal fields, but also plays an important role in determining the maturation phase of the ultra‐deep source rocks and the occurrence state of hydrocarbons in the Tarim and Sichuan basins.
A comprehensive insight into effects of resveratrol on molecular mechanism in rheumatoid arthritis: A literature systematic review
Authors: Karimi Arash , Azar Pouria Sefidmooye , Kadkhodayi Mahtab , Tandorost Arash , Vajdi Mahdi , Shoorei Hamed , Farhangi Mahdieh Abbasalizad
Published: June 2022

Aim

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is characterized by massive pain and destruction of synovial joints, leads to bone erosion, damage to cartilage, and disability. Several studies suggested that resveratrol supplementation may be effective in the prevention and management of RA. Therefore, a systematic review was conducted to summarize published studies that assess the effect of resveratrol supplementation on the complications of RA.

Methods

A comprehensive search to identify in vitro, animal, and human studies investigating the impact of resveratrol on the complications of RA was performed up to February 2022. Two independent reviewers evaluated studies based on inclusion/exclusion criteria and performed data extraction.

Results

All studies examining the effects of resveratrol supplementation on the complications of RA were included. From a total of 571 retrieved articles, 32 studies were eligible for the current systematic review. The evidence reviewed here indicates that resveratrol supplementation may exert beneficial effects on the complications of RA by attenuating inflammation and oxidative stress, modulating the immune response, and down‐regulating the messenger RNA expression of genes related to inflammatory pathways.

Conclusion

Due to the promising therapeutic effects of resveratrol on RA complications and limited number of human studies in this subject, further clinical trials are suggested.
Existing and emerging uses of drones in restoration ecology
Authors: Robinson Jake M. , Harrison Peter A. , Mavoa Suzanne , Breed Martin F.
Published: June 2022

In the absence of effective and scalable human intervention, up to 95% of the world's ecosystems will be affected by anthropogenic degradation by 2050. Therefore, immediate and large‐scale ecological restoration is imperative to stem biodiversity loss and ecosystem decline. Ecologists must draw upon the most effective and efficient tools available to achieve successful restoration goals. Drones (i.e., unmanned aerial vehicles) are a valuable set of tools in the environmental, forestry, and agriculture sectors; however, there has been limited uptake in restoration ecology.

Here, we aim to highlight the existing and emerging uses of drones in restoration science and practice. We discuss the strengths and weaknesses of these applications and provide a roadmap for increasing the utilisation of drones to refine and enhance restoration objectives. Our article is presented with the restoration continuum in mind, including sections for restoration planning, implementation and monitoring. We also take a novel approach by describing how drones relate to a globally recognised restoration tool published by the Society for Ecological Restoration.

Drones are used in several restoration scenarios from mapping habitats and managing wildfires, to monitoring the effectiveness of restoration interventions. Many applications in other disciplines can also be transferred to restoration scenarios. However, the use of drones will be context‐dependent, and several technical and practical constraints need to be addressed.

Drones have considerable potential to improve the science and practice of restoration at all stages of a restoration project, which is vital to realising the goals of the UN Decade on Ecosystem Restoration.
Nomogram based on the systemic immune‐inflammation index for predicting the prognosis of diffuse large B‐cell lymphoma
Authors: Wu Jing , Zhu Haizhen , Zhang Qi , Sun Yi , He XinYun , Liao Jiaqun , Liu Yuncong , Huang Limin
Published: June 2022

Aim

To investigate systemic immune‐inflammation index (SII) as prognostic factors and establish a nomogram based on SII for the prediction of survival in diffuse large B‐cell lymphoma (DLBCL).

Methods

One hundred and fifty‐five DLBCL patients were randomized into primary (N = 100) and validation (N = 55) cohorts. Kaplan–Meier survival curves and Cox regression models were used to evaluate the impact of SII on survival. The nomogram based on SII was analyzed by using R software.

Results

Univariate and multivariate analyses revealed that high SII (>1684.), C‐reactive protein‐to‐albumin ratio (CAR > 0.21), and age‐adjusted International Prognostic Index (aaIPI) score were independent predictors of overall survival (OS). High SII and aaIPI were independent predictors of progression‐free survival. The nomogram had better accuracy and discrimination than the International Prognostic Index, National Comprehensive Cancer Network‐International Prognostic Index, and aaIPI systems. The concordance index values of the nomogram for OS were 0.885 in the primary cohort and 0.821 in the validation cohort.

Conclusions

Our results suggested that SII, CAR, and aaIPI could be used to judge the prognosis of DLBCL patients. The nomogram was a reliable model for predicting the OS of DLBCL patients.
The reciprocal relationship between social identification and social support over time: A four‐wave longitudinal study
Authors: Häusser Jan , Abdel Hadi Sascha , Reichelt Charlene , Mojzisch Andreas
Published: June 2022

It has been argued that the positive effect of a shared social identity on health and well‐being critically hinges on the interplay between social identity and social support. This interplay, however, is poorly understood. Building on Haslam et al., we argue that their relationship can be conceptualized as being reciprocal and dynamic with each variable influencing the other. The present study is the first to examine how the reciprocal relationship between social identification and perceived social support unfolds over time. In a sample of university freshmen (NT1 = 172), we examined this reciprocal relationship in a four‐wave survey study spanning over a period of 13 months. In line with Haslam et al., the results revealed a self‐reinforcing cycle with social identification at T1 being positively related to perceived social support at T2, which, in turn, was positively related to social identification at T3, which predicted perceived social support at T4. In conclusion, our study advances knowledge regarding the interplay between social identity and social support over time and, hence, contributes to our understanding of the mechanisms underlying the social cure effect.
Influence of response to prior docetaxel on sensitivity to cabazitaxel in prostate cancer patients with PTEN alterations
Authors: Kamisawa Ken , Kosaka Takeo , Nakamura Kohei , Yasumizu Yota , Hongo Hiroshi , Takeda Toshikazu , Matsumoto Kazuhiro , Nishihara Hiroshi , Oya Mototsugu
Published: June 2022

The purpose of this study was to investigate factors predicting the sensitivity to cabazitaxel therapy in metastatic castration‐resistant prostate cancer (mCRPC) patients with phosphatase and tensin homolog deleted from chromosome 10 (PTEN) alterations. This single‐institution, retrospective study included 12 mCRPC patients with PTEN alterations who had received cabazitaxel therapy. Five patients (41%) responded to cabazitaxel therapy with a prostate‐specific antigen (PSA) level decline of ≥30% from baseline, and all of them had responded to prior docetaxel therapy with a PSA decline of ≥30%. None of the patients with a poor response to prior docetaxel therapy responded well to cabazitaxel therapy. Of the seven patients who did not respond to cabazitaxel and whose PSA declined from baseline was <30%, five (71%) were also refractory to prior docetaxel therapy. The PSA responses to docetaxel and cabazitaxel were significantly correlated (p = 0.027). Kaplan–Meier analysis revealed that progression‐free survival (PFS) for cabazitaxel was significantly shorter for prior docetaxel nonresponders (3.3 versus 9.1 months, p = 0.028). Multivariate analysis revealed that a poor response to prior docetaxel (PSA decline < 30%) (hazard ratio [HR] = 6.382, 95% confidence interval [CI] 1.172–34.750, p = 0.032) and baseline PSA of ≥20 ng/ml (HR = 33.584, 95% CI 2.332–483.671, p = 0.010) were independent prognostic factors for PFS with cabazitaxel therapy. These results demonstrate cross‐resistance between docetaxel and cabazitaxel. The response to prior docetaxel therapy can influence the sensitivity to cabazitaxel therapy in mCRPC patients with PTEN alterations.
Cretaceous lophocoronids with short proboscis and retractable female genitalia provide the earliest evidence for their feeding and oviposition habits
Authors: Zhang Weiting , Shih Chungkun , Engel Michael S. , Ren Dong
Published: June 2022

We describe two new species of Lophocoronidae: Acanthocorona hedida Zhang, Shih and Engel sp. n. and Acanthocorona venulosa Zhang, Shih and Engel sp. n., and an undetermined specimen from mid‐Cretaceous Kachin amber. Phylogenetic analysis of basal lepidopteran lineages, including three extinct families, was undertaken. The analysis supported monophyly of Glossata although internal relationships remain controversial. Acanthocorona and Lophocorona form a monophyletic group. It is likely that short and simply structured proboscides of Acanthocorona were used to sip water droplets, pollination drops from gymnosperms, nectar from early flowers, or sap from injured leaves. Both retracted and extended ovipositors are preserved in the material reported here, revealing their morphology and indicating that these Cretaceous lophocoronids inserted eggs into the tissues of their host plants.
The Lutheran transformation of passion devotion, 1520–1560, and lessons for today
Authors: Evener Vincent
Published: June 2022

This article examines how early Lutheran authors transformed three pedagogical strategies prominent in late‐medieval passion books: the use of Mary the mother of Jesus and Mary Magdalene as models for feeling in relationship to Christ; graphic depiction of Christ's wounded body; and the practice of “composition of place,” that is, imagining oneself in the scene of the crucifixion. It argues that early Lutheran authors transformed these strategies to equip lay Christians to endure temporal setbacks and persecution; they were to find Christ's body in the present, in themselves and their neighbors, and to discern invulnerability and triumph underneath the apparent opposite. This article commends practices of imagined relationship to Christ and of reading the present through the passion for Christians and the church today. Equally important are the warnings about human vulnerability to deceit found in these texts, which insist on the interconnection of discernment, feeling, and relationship.
A combination of severe complications in a case of infective endocarditis: Dehiscence of prosthetic aortic valve, aortic dissection, pseudoaneurysm, and hematoma causing right ventricular collapse
Authors: Sonsoz Mehmet Rasih , Cetin Ilyas , Kilicgedik Alev , Inan Duygu , Ozates Yelda Saltan , Yanartas Mehmed , Kayalar Nihan
Published: June 2022

Prosthetic valve endocarditis with mechanical complications causing pulmonary edema is fatal, therefore it needs to be diagnosed early and should be treated surgically in emergency setting. Transesophageal echocardiogram is crucial for recognizing the mechanical complications, which can be encountered on daily practice, but the coexistence of complications occurring on different mechanism is rather uncommon. Herein, we report a 21‐year‐old gentleman presenting with acute heart failure, whose imaging tests showed a combination of dehiscence of mechanical aortic valve prosthesis, aortic dissection, pseudoaneurysm, and hematoma causing right ventricular collapse.