bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of nutritional supplements on antibody levels in pregnant women vaccinated with inactivated SARS-CoV-2 vaccines
Authors: Zhang Xi , Han Xue , Chen Baolan , Fu Xi , Gong Yajie , Yang Wenhan , Chen Qingsong
Published: July 2023

Background

Because of the significantly higher demand for nutrients during pregnancy, pregnant women are more likely to have nutrient deficiencies, which may adversely affect maternal and fetal health. The effect of nutritional supplements on the immune effects of inactivated SARS-CoV-2 vaccines during pregnancy is not clear.

Methods

In a multicenter cross-sectional study, we enrolled 873 pregnant women aged 18-45 y in Guangdong, China. The general demographic characteristics of pregnant women and their use of nutritional supplements were investigated, and the serum antibody levels induced by inactivated SARS-CoV-2 vaccines were measured. A logistic regression model was used to analyze the association between nutritional supplements and SARS-CoV-2 antibody levels.

Results

Of the 873 pregnant women enrolled, 825 (94.5%) took folic acid during pregnancy, 165 (18.9%) took iron supplements, and 197 (22.6%) took DHA. All pregnant women received at least one dose of inactivated SARS-CoV-2 vaccine, and the positive rates of serum SARS-CoV-2 neutralizing antibodies (NAbs) and immunoglobulin G (IgG) antibodies were 44.7% and 46.4%, respectively. After adjustment for confounding factors, whether pregnant women took folic acid, iron supplements, or DHA did not influence NAb positivity or IgG positivity (P> 0.05).Compared with pregnant women who did not take folic acid, the odds ratios (ORs) for the presence of SARS-CoV-2 NAb and IgG antibody in pregnant women who took folic acid were 0.69 (P= 0.282; 95% CI, 0.35-1.35) and 1.31 (P= 0.456; 95% CI, 0.64-2.67), respectively. Compared with pregnant women who did not take iron supplements, the ORs for the presence of NAb and IgG antibody in pregnant women who took iron supplements were 1.22 (P= 0.336; 95% CI, 0.81-1.84) and 1.01 (P= 0.956; 95% CI, 0.66-1.54), respectively. Similarly, the ORs for NAb and IgG antibody were 0.74 (P= 0.125; 95% CI, 0.51-1.08) and 0.97 (P= 0.881; 95% CI, 0.66-1.44) in pregnant women who took DHA compared with those who did not.

Conclusions

Nutritional supplementation with folic acid, iron, or DHA during pregnancy was not associated with antibody levels in pregnant women who received inactivated SARS-CoV-2 vaccines.
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
Authors: Simon Márton A. , Iordanov Iordan , Szöllősi András , Csanády László
Published: July 2023

CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings. Bursts of CFTR pore openings are coupled to tight dimerization of its two nucleotide binding domains (NBDs) and in wild-type (WT) channels are mostly terminated by ATP hydrolysis. The slow rate of non-hydrolytic closure – which determines how tightly bursts and ATP hydrolysis are coupled – is unknown, as burst durations of catalytic site mutants span a range of ∼200-fold. Here we show that Walker A mutation K1250A, Walker B mutation D1370N, and catalytic glutamate mutations E1371S and E1371Q all completely disrupt ATP hydrolysis. True non-hydrolytic closing rate of WT CFTR approximates that of K1250A and E1371S. That rate is slowed ∼15-fold in E1371Q by a non-native inter-NBD H-bond, and accelerated ∼15-fold in D1370N. These findings uncover unique features of the NBD interface in human CFTR.
Chromosome level assembly of wild spinach provides insights into the divergence of homo- and heteromorphic plant sex-chromosomes
Authors: Severing Edouard I. , van der Werf Edwin , van Kaauwen Martijn P.W. , Kodde Linda , Kik Chris , van Treuren Rob , Visser Richard G.F. , Finkers Richard , Bai Yuling
Published: July 2023

Background

Cultivated spinach (Spinacia oleracea)is a highly nutritional crop species of great economical value that belongs to a genus of dioecious plant species with both homomorphic and heteromorphic sex chromosomes. The wild spinach speciesSpinacia turkestanicaandSpinacia tetrandraare important genetic sources for improving cultivated spinach and excellent material for studying sex chromosome evolution in plants. However, until now there were no publicly available genome assemblies for these species.

Results

Here we sequenced and assembled the genomes ofS. turkestanicaandS. tetrandraand performed a tri-way comparative analysis withS. oleracea. We show that many abiotic- and biotic stress related gene clusters have expanded through tandem duplication inS. tetrandraafter it diverged from theS. turkestanica-S. oleracealineage. Focussing on the sex chromosomes we found that the previously identified inversion distinguishing theS. oleraceamale- and female-SEX DETERMINING REGIONs (SDRs) is conserved inS. turkestanica. Although, the SDRs of these two species coincides with the PSEUDO AUTOSOMAL REGION ofS. tetrandrathe gene content is only partially conserved and the genetic factors determining sex in these species might differ. Finally, we show that recombination suppression between theS. tetrandraX- and Y-chromosomes resulted in a highly degenerated Y-chromosome and started before the species diverged fromS. turkestanicaandS. oleracea.

Conclusions

We expect that the novel wild spinach species genomes are of great value to the breeding community and evolutionary biologist especially focussing on the evolution of sex chromosomes in plants.
Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion
Authors: Martí-Pàmies Íngrid , Thoonen Robrecht , Morley Michael , Graves Lauren , Tamez Jesus , Caplan Alex , McDaid Kendra , Yao Vincent , Hindle Allyson , Gerszten Robert E. , Farrell Laurie A. , Li Li , Tseng Yu-Hua , Profeta Gerson , Buys Emmanuel S. , Bloch Donald B. , Scherrer-Crosbie Marielle
Published: July 2023

BACKGROUND:

Despite advances in treatment, myocardial infarction (MI) is a leading cause of heart failure and death worldwide, with both ischemia and reperfusion (I/R) causing cardiac injury. A previous study using a mouse model of nonreperfused MI showed activation of brown adipose tissue (BAT). Recent studies showed that molecules secreted by BAT target the heart. We investigated whether BAT attenuates cardiac injury in I/R and sought to identify potential cardioprotective proteins secreted by BAT.

METHODS:

Myocardial I/R surgery with or without BAT transplantation was performed in wild-type (WT) mice and in mice with impaired BAT function (uncoupling protein 1 [
Ucp1
]–deficient mice). To identify potential cardioprotective factors produced by BAT, RNA-seq (RNA sequencing) was performed in BAT from WT and
Ucp1

−/−

mice. Subsequently, myocardial I/R surgery with or without BAT transplantation was performed in
Bmp3b
(bone morphogenetic protein 3b)–deficient mice, and WT mice subjected to myocardial I/R were treated using BMP3b.

RESULTS:

Dysfunction of BAT in mice was associated with larger MI size after I/R; conversely, augmenting BAT by transplantation decreased MI size. We identified Bmp3b as a protein secreted by BAT after I/R. Compared with WT mice,
Bmp3b
-deficient mice developed larger MIs. Increasing functional BAT by transplanting BAT from WT mice to
Bmp3b
-deficient mice reduced I/R injury whereas transplanting BAT from
Bmp3b
-deficient mice did not. Treatment of WT mice with BMP3b before reperfusion decreased MI size. The cardioprotective effect of BMP3b was mediated through SMAD1/5/8. In humans, the plasma level of BMP3b increased after MI and was positively correlated with the extent of cardiac injury.

CONCLUSIONS:

The results of this study suggest a cardioprotective role of BAT and BMP3b, a protein secreted by BAT, in a model of I/R injury. Interventions increasing BMP3b levels or targeting Smad 1/5 may represent novel therapeutic approaches to decrease myocardial damage in I/R injury.
Έλληνες και ελληνικής καταγωγής συνθέτες της διασποράς με συνθετικό έργο μετά το 1950
Authors: Παπαματθαίου-Μάτσκε Δανάη
Published: July 2023

Η παρούσα διατριβή ξεκίνησε ως έρευνα για έργα με τίτλο Σονάτα για βιολί και πιάνο Ελλήνων και ελληνικής καταγωγής συνθετών της διασποράς μετά το 1950 με σκοπό το περιεχόμενό της να οργανωθεί σε δύο μέρη. Κατόπιν εννοιολογικής αποσαφήνισης του όρου «διασπορά», η έρευνα εστιάστηκε σε τέσσερεις ερευνητικές υποθέσεις: στην επίδραση εθνικών καταβολών στη συνθετική δημιουργία των συνθετών της διασποράς, στα περιθώρια εξέλιξης της μορφής της σονάτας, στο βιολί ως βασικό όργανο της σύγχρονης συνθετικής δημιουργίας και στη δυνατότητα εξέλιξης συνθετικών πειραματισμών και νέων εκφραστικών δυνατοτήτων του συνδυασμού βιολί/πιάνο. Το Μέρος Ι επιχειρεί να διερευνήσει τις υποθέσεις αυτές μέσω εμπειρικής έρευνας - τόσο ποσοτικής μέσω ερωτηματολογίων όσο και ποιοτικής μέσω ημιδομημένων συνεντεύξεων - με απώτερο στόχο να παρέχει εμπειρικό υπόβαθρο στην αναλυτική, ερμηνευτική και κριτική προσέγγιση δύο αντιπροσωπευτικών έργων συνθετών της διασποράς του Μέρους ΙΙ (Σονάτα για βιολί και πιάνο του Ντίνου Κωνσταντινίδη [1971/77] και Σονάτα για βιολί και πιάνο του Boris Papandopulo [1988]), τα οποία βρίσκονται στο επίκεντρο της εστίασης της παρούσας διατριβής. Στο πλαίσιο της μελέτης των δύο αυτών περιπτώσεων, τα έργα προσεγγίζονται κριτικά τόσο σε σχέση με ζητήματα δομικής οργάνωσης, όσο και σε σχέση με ζητήματα εκτελεστικής πρακτικής και μουσικής ερμηνείας. Τα πορίσματα της έρευνας καταδεικνύουν αφενός την ύπαρξη πρωτότυπων έργων σε διακριτή μορφή σονάτας στα τέλη του 20ού αιώνα, αφετέρου την υποχώρηση ελληνικών επιρροών σε δημιουργούς της διασποράς. Η έρευνα οδήγησε, κατόπιν συγκριτικής διασταύρωσης των διαθέσιμων πηγών, στην κατάρτιση αναθεωρημένων εκδόσεων των δύο έργων καθώς και σε δημόσιες εκτελέσεις, ηχογραφήσεις και μαγνητοσκόπηση νέων πρωτότυπων μουσικών ερμηνειών, ενημερωμένων από τα συμπεράσματα της έρευνας. Με τον τρόπο αυτόν, η παρούσα διατριβή στοχεύει, παράλληλα με την απάντηση των ερευνητικών ερωτημάτων, στον εμπλουτισμό του ρεπερτορίου των δύο οργάνων, κάνοντας διαθέσιμες σύγχρονες και αξιόπιστες παρτιτούρες, ερμηνευτικά σχόλια και μαγνητοσκοπημένες ερμηνείες των δύο υπό διερεύνηση έργων.
Barbie eta superman: beste aukerarik ote?
Authors: Gutiérrez Estibaliz , Perez de Pipaon Galder
Published: July 2023

Diziplinartekotasunak hainbat abantaila izan ditzake Lehen Hezkuntzan, horien artean kontzeptu teoriko eta metodologia praktikoen artean loturak ezartzea, edota eguneroko arazoei aurre egiteko ikuspuntu eta baliabide desberdinak garatzeko aukera ematea. Planteamendu horretatik abiatuta kasu azterketa bat egiten da bi helburuekin, alde batetik 6. mailako ikasleriak dituen gorputz osasuntsuari buruzko aurreiritziak identifikatzea, eta bestetik gai horri buruzko ezagutzak garatzeko Gorputz Hezkuntza eta Artearen Hezkuntzaren bidezko proiektu baten eraginkortasuna ebaluatzea. Emaitzak erakusten dutenez, parte-hartzaileen osasunari eta gorputz irudiari buruzko aurreiritziak zuzenki erlazionatuta daude ikusizko kulturan kontsumitzen dituzten estereotipoekin. Horretaz gain, ondorioztatu da Artearen Hezkuntza eta Gorputz Hezkuntzaren arteko elkarlanak ikasleen adierazpen gaitasunak sustatzen dituela, osagarriak diren hiru komunikazio-bide eskaintzen baititu: hitzen bidezkoa, gorputz adierazpena eta ikusizko lengoaia. Gainera, metodologia praktiko, motibatzaile eta erakargarrien bidez parte-hartzaileek eduki eta eredu berriak barneratzea lortzen dute, baita beraien aurreiritziaz hausnartzea eta estereotipatutako irudiei buruzko pentsamendu kritikoa garatzea ere, gorputz aniztasunarekiko begirunea suspertuz.
EN PRENSA. Frutos de Mango Partenocárpicos y Estenospermocárpicos: Factores Causantes. EN PRENSA
Authors: Arias Navarro C.F , Balois-Morales R. , Jiménez Zurita J.O. , Ochoa Jiménez V.A. , Pérez Ramírez I.F. , Berumen Varela G. , Bautista Rosales Pedro Ulises
Published: July 2023

Los frutos de mango (Mangifera indica L.) son de importancia comercial por su consumo en fresco y procesado. A nivel mundial se producen aproximadamente 52,000 t por año, principalmente en la India, China, Tailandia, Indonesia, Pakistán, México, Brasil, Bangladesh, Nigeria y Filipinas. Sin embargo, la producción y comercialización de este fruto se ve afectada por el desarrollo de mangos partenocárpicos y estenospermocárpicos al no cumplir con estándares de calidad como tamaño y peso. Se han llevado a cabo investigaciones que intentan resolver el problema o encontrar el factor causante, entre los cuales se menciona a la temperatura, nutrientes y fitohormonas como los responsables de estas fisiopatías en mango. El objetivo de esta investigación es hacer un análisis de las investigaciones que se han realizado tratando de explicar los factores que intervienen en el desarrollo de la partenocárpia y estenospermocárpia en frutos de mango.
Gauge Fields and Quantum Dynamics at the Event Horizon and Beyond
Authors: Ganesan Timothy
Published: July 2023

The field dynamics of neutral and charged matter (treated as gauge fields) beyond the event horizon of black holes are investigated. As an extension of the work done in Ganesan (2023) [1], the analysis was done using the combined dynamics of the two-dimensional Yang-Mills and Liouville gravity fields beyond the event horizon. The quantum interactions and symmetry breaking mechanisms of the combined two-dimensional fields are discussed. The second part of this paper explores the quantum dynamics occurring at the event horizon. By considering the structure of the event horizon as a Möbius strip (embedded in three-dimensional space), a formulation for the lower bound of the first energy eigenvalue of a quantum particle (electron) at the event horizon is obtained.
The Policy Role of Bank Syariah Indonesia for MSMEs Sector in Community Economic Empowerment
Authors: Habibi Ahmad , Utami Pertiwi , Muzammil Rozina , Nasor Muhammad
Published: July 2023

The people's economy can be improved through the micro business sector. The issue of the role of Bank Syariah Indonesia (BSI) as a competent Islamic bank is a new hope for these business actors. Unfortunately, previous studies have not disclosed in depth the programs and policies of BSI after the merger. This study aims to determine the policy of Islamic banking toward the micro-business sector to empower the community's economy. The study was conducted on Bank Syariah Mandiri (BSM), which merged with two other large Islamic banks, Bank Rakyat Indonesia Syariah (BRI Syariah) and Bank Negara Indonesia Syariah (BNI Syariah), and became BSI. The research design used a qualitative approach with data collection techniques in interviews, observation, and documentation. BSI is a bank that collects and distributes funds to the public based on sharia principles. The findings show that BSI maintained its reputation as a competent Islamic bank in community empowerment efforts. This is evidenced by the inclusion of BSI in the Forbes list of The World's Best Banks 2021 because it has met the criteria for trust, terms and conditions, customer services, digital services, and financial advice. Although it has merged with two other Islamic banks, BSM continues to use the same system as before, except for some adjustments related to product policies regarding costs, benefits, and margin provisions by applicable regulations. Community empowerment through Micro Business products refers to Law Number 21 of 2008 concerning Islamic Banking. In its development, to support the community's economy, BSI carries out a sustainable finance agendavillage economic programs, food security, sociopreneur scholarships, and siding with MSMEs.
Keywords: Bank Syariah Indonesia; policy; MSMEs
Patterns of diversity and phylogenetic community structure in free-living Nematodes: a metabarcoding meta-analysis
Authors: Macheriotou Lara , Derycke Sofie , Vanreusel Ann
Published: July 2023

Identifying and understanding patterns of biological diversity is
crucial at a time when even the most remote and pristine marine
ecosystems are threatened by resource exploitation such as deep-seabed
mining. Metabarcoding provides the means through which to perform
comprehensive investigations of diversity by examining entire
assemblages simultaneously. Nematodes commonly represent the most
abundant infaunal metazoan group in marine soft sediments. In this
meta-analysis, we compiled all publicly available metabarcoding datasets
targeting the 18S rRNA v1-v2 region from sediment samples to conduct a
global-scale examination of nematode Amplicon Sequence Variant (ASV)
alpha diversity patterns, evolutionary distinctiveness (ED) and
phylogenetic community structure at different depths and environments.
We found that nematode ASV richness followed a parabolic trend,
increasing from the intertidal to the shelf, reaching a maximum in the
bathyal and decreasing in the abyssal zone. No depth- or
environment-specific assemblages were identified as a large fraction of
genera were shared. Contrastingly, the vast majority of ASVs were unique
to each environment and/or depth zone; genetic diversity was thus highly
localised. The abyssal samples had the highest ED values, indicating
that a relatively stable yet very old environment can produce highly
diversified assemblages. Overwhelmingly, nematode ASVs in all
environments exhibited phylogenetic clustering, pointing to
environmental filtering as the primary force defining community assembly
rather than competitive interactions. This finding stresses the
importance of habitat preservation for the maintenance of marine
nematode diversity.
Effects of Delivery Method on Skin Diseases and Allergy Status Depending on Sociodemographic Characteristics
Authors: Metin Zuhal , Durmaz Koray
Published: July 2023

Background Recent data support a relationship between gut
microbiota and various chronic diseases, with emerging evidence
indicating a similar association with skin microbiota. This study
examined the impact of delivery method on skin microbiota and explored
its effects on skin diseases and allergies. Sociodemographic
characteristics, which are potential factors impacting skin microbiota,
were also considered to investigate this relationship. Methods
A cross-sectional study was conducted with 285 pediatric patients. The
delivery method, allergy status, age, gender, consanguineous marriage
and parental smoking exposure factors were questioned. The present
diagnoses of the patients were also recorded. Categorical variables were
analyzed using chi-square analysis and a binary logistic test was used
for further analysis. Results An increased risk of infectious
skin diseases (viral, bacterial, fungal) and allergies has been observed
in cesarean section (p<0.001, p=0.057). The risk of scabies
was higher in normal delivery (p=0.032). There was no significant
relationship between the method of delivery and atopic or non-atopic
dermatitis. For children born by cesarean section, parental smoking
exposure and allergies were identified as factors increasing the risk of
atopic dermatitis (p=0.045, p=0.018). Allergic children born by cesarean
section exhibited a lower prevalence of infectious skin diseases
(p=0.037). In addition, a decrease in infectious skin diseases from
21,2% to 10,3% was observed after 3 years of age in normal births
(p=0,139). Conclusions Minimizing sociodemographic risk factors
and creating a balanced and healthy microbiota, especially in early
life, through personal and environmental measures, will be an important
part of the treatment of skin diseases and allergies.
Perception Teacher to leadership Principal SDN 13 Surau Gadang
Authors: Halimahturrafiah Nur , Dewi Fitra , Gistituati Nurhizrah
Published: July 2023

The purpose of this study was to determine the teacher's perception of the leadership of the principal of the State Elementary School 13 Surau Gadang seen from influencing, moving and motivating. This research includes descriptive research, the population is 16 people who teach at SDN 13 Surau Gadang. The sampling technique used is total sampling. The instrument uses a questionnaire/questionnaire. Research results In general, the teacher's perception of the leadership of the Principal of the State Elementary School 13 Surau Gadang is on an average score of 4.5 with a good category. This means that the leadership at the State Senior High School 1 Lembah Melintang has been going well. That the principal's leadership must be able to encourage the performance of teachers by showing a sense of friendship, closeness, and consideration for teachers, both as individuals and as groups.
Kajian Analisis Kearifan Lokal Sebagai Landasan Konservasi Ikan Barau (Hampala macrolepidota)
Authors: Permana Rega , Delami Apri Nur
Published: July 2023

Hampala barb (Hampala macrolepidota) is one of the commercial freshwater fish in Indonesia which is commonly caught in lakes and rivers in Sumatra. Due to the high market demand and habitat destruction, the new fish population is under pressure which affects its sustainability in nature. One of the efforts to preserve hampala barb is through the implementation of local wisdom in the form of the Mancokao tradition. This paper aims to examine the role of local wisdom in the conservation of hampala barb. Mancokao traditional activities as a form of local wisdom are one of the good management approaches because they involve the community in its implementation. Government support and its integration with the initiation of tourism areas can help sustain this tradition and at the same time as an effort to conserve this fish resourcesAbstrakIkan barau (Hampala macrolepidota) merupakan salah satu ikan air tawar komersial di Indonesia yang umum ditangkap di danau maupun sungai di daerah Sumatera. Permintaan pasar yang tinggi dan kerusakan habitat populasi ikan barau mengalami tekanan sehingga mempengaruhi kelestariannya di alam. Salah satu upaya pelestarian ikan barau di tempuh melalui pelaksanaan kearifan local berupa tradisi mancokao. Tulisan ini bersifat deskriptif dan bertujuan untuk mengkaji peranan kearifan lokal dalam konservasi ikan barau. Kegiatan tradisi mancokao sebagai bentuk kearifan local menjadi salah satu pendekataan pengelolaan yang baik karena melibatkan masyarakat dalam pelaksanaannya. Dukungan pemerintah dan integrasinya dengan inisiasi kawasam wisata dapat membantu keberlanjutan tradisi ini dan secara bersamaan sebagai upaya konservasi sumberdaya ikan barau
IDENTIFICATION OF CULTURAL TOURISM ATTRACTIONS OF SEKADAU HILIR DISTRICT, SEKADAU REGENCY
Authors: Erni Yuniarti
Published: July 2023

Tourism is one of the important sectors in the development of Indonesia, especially in cultural attractions. Cultural heritage tourism in Sekadau Regency, West Kalimantan Province consists of 4 tours, 2 of which are located in the center of the district capital, namely Lawang Kuari Cave and King of Sekadau Tomb. Both tours are potential historical sites to be developed as ODTW (Objects and Tourist Attractions) in Sekadau Regency. The cultural attractions of Sekadau Hilir District have problems in the form of unregulated cultural attractions to the characteristics of the district. The data analysis method used is qualitative descriptive analysis, which is reviewed based on variables: attraction, facilities, support, and additional services. Based on the results of identification, known that ODTW culture in Sekadau Hilir District consists of (1) art, (2) a livelihood system, (3) cultural tourism festivals, (4) palaces, and (5) sites, buildings, and historical monuments. The driving factor for the development of cultural tourism is the availability of cultural attractions that can attract tourists, both from the tourist of internal and outside the area. Inhibiting factors in the development of cultural tourism are lack of promotion, lack of availability of infrastructure and tourism support facilities, and inadequate human resources.
PERFORMANCE ANALYSIS OF BANJAR SUGIHAN ROAD (STA 0+000-03+000) DIRECTION TO BENOWO, SURABAYA CITY, EAST JAVA PROVINCE USING MKJI 1997 METHOD
Authors: Romadhon Adam , Fatmawati Laily Endah , Hartatik Nurani
Published: July 2023

Transportation is important as a tool for to go everyday. The increased demand for transportation causes an increase in traffic flow and volume of vehicles which will then cause congestion. One of the traffic jams that occur in the city of Surabaya is on the Banjar Sugihan road. The purpose of this study is to review and analyze the density of traffic flow that occurs on the Banjar Sugihan road, so that it can solve congestion problems and improve services. The method in this study was carried out by conducting traffic surveys to collect primary data which was carried out for three days during rush hour (06.00-17.00) which was guided by the 2014 PKJI. This research resulted in a large volume of vehicles, large capacity roads, as well as the performance of the Banjar Sugihan highway section. From the results of the study it can be concluded that the Banjar Sugihan highway is a road that is densely packed with vehicles, the performance of the Banjar Sugihan Street section has a forced or jammed flow, low speed, volume below capacity. The queues were long and there were big obstacles.
3D Biomimetic in Vitro Model of Self-induced Cardiac Ischemia Based on the Co-culture of Cardiomyocytes Derived from hiPSC and Primary Human Cardiac Fibroblast
Authors: Laura Paz Artigas  , González-Lana Sandra , Polo Nicolás , Castro-Abril Héctor , Mazo Manuel M. , Ochoa Ignacio , Ciriza Jesús
Published: July 2023

Large cardiac spheroids (i.e., > 500 µm diameter) that self-induce an ischemic core were generated by co-culture of cardiomyocytes derived from induced pluripotent cells (hiPSC-CMs) and primary cardiac fibroblast (hCF). Without modification of culture conditions, spheroids’ large size allowed the recreation of a dead core, fibrotic remodelling and tissue stiffening.
Development of the technological process of preserving sheepskins with a new salting composition
Authors: Sydykova Gulzhamal Ergalievna , Smagulova Zauresh Turcynkhanovna , Elena N. Moiseeva Elena Nikolaevna , Derbyshev Kamil Yurievich
Published: July 2023

The article presents the results of studies of the whey-salt method of preserving sheepskin raw materials. The peculiarity of this method is that the use of table salt in the preservative composition is reduced due to the use of whey; the duration of the skin processing process is reduced by 1.5-2.0 times compared to the traditional method, the canning process is reduced from 8 to 4 hours, the drying process is reduced from 72 to 48-50 hours. The use of this method of processing sheepskins makes it possible to reduce the cost of the canning process, reduce the pollution of wastewater from enterprises, and improve the quality of hides.
Evaluación de la absorción de humedad de leche en polvo envasada en diferentes materiales y almacenada a diferentes condiciones de humedad relativa
Authors: Soto-Flores S.C. , Amador-López L.F. , Martínez-García J.J. , Candelas-Cadillo M.G. , Minjares-Fuentes J.R.
Published: July 2023

La leche en polvo al ser un producto deshidratado es altamente perecedero cuando se expone a condiciones extremas de almacenamiento. Por esto, el objetivo de este estudio fue evaluar la absorción de humedad de leche en polvo envasada en diferentes materiales de envase y almacenada en diferentes condiciones de humedad relativa. Aproximadamente 5 g de leche en polvo fueron envasados en diferente material de envase (papel, plástico y aluminio) y almacenados a tres diferentes condiciones de humedad relativa (11%, 32% y 78%) a 25 ºC. El incremento de peso fue monitoreado cada 8 h durante 5 días. Una muestra expuesta directamente a la condición de almacenamiento fue tomada como testigo. La leche envasada en papel presentó un mayor incremento de peso en las distintas humedades de almacenamiento, alcanzando un incremento de aproximadamente 30%, superando en algunos casos a la muestra testigo, lo cual podría ser atribuido a la absorción de agua por parte del material. Por el contrario, la leche envasada en aluminio fue la que presentó la menor tasa de absorción de humedad (1.16´10–4 g/g·h). Estos resultados demuestran que el aluminio extiende la vida útil de un producto deshidratado debido a la baja tasa de absorción de agua.
Pan gourmet a base de harina de trigo, linaza y chapulín (Sphenarium purpurascens) como alimento funcional
Authors: Gomez- Galicia P.F , Parola-Contreras I. , Báez- González Juan Gabriel , Durán-Lugo R.
Published: July 2023

Hoy en día las enfermedades no transmisibles (ENT) se han vuelto una de las principales causas de muerte a nivel mundial, debido a diversos motivos que van desde el sedentarismo, la mala alimentación, sobrepeso u obesidad, tabaquismo, alcoholismo o bien genética. Para esto se propone la creación de un producto funcional pan gourmet a base de harina de trigo, linaza y chapulín (Sphenarium purpurascens) (PHTLC) para contribuir en la dieta de personas con estas enfermedades, principalmente el cáncer de colon. La elaboración del producto se lleva a cabo en los laboratorios del Tecnológico de Estudios Superiores de Chimalhuacán pretendiendo obtener resultados favorables en las personas que consuman el producto.
Pengembangan E-Modul Matematika Berbasis Matematika Realistik Bernilai Budaya Kediri pada Materi Perbandingan
Authors: Nurfadilah Zenik , Hamidah Dewi , Wulan Eka Resti
Published: July 2023

Based on the results of observations, the activeness of the Comparative Mathematics learning process in class VII E MTsN 2 Kediri City is still relatively low. This is because the teaching materials used are only printed teaching materials. The aim of study was to develop a Mathematics E-Module on Comparative Material with a Realistic Mathematics Approach in collaboration with Kediri Culture. This study uses the R&D method with the ADDIE model which consists of 5 stages, namely Analysis, Design, Development, Implementation, and Evaluation. The research instruments used were material expert validation sheets, media experts, teacher response sheets, and student responses. The data analysis technique in this research is descriptive quantitative analysis. The experimental subjects in this study were students at MTsN 2 Kediri City. The results of this study indicate that the e-module developed is in the very good category with an average score of 94.5% from material expert validation, from media experts at 82.5%, from teacher response sheets at 100%, from group trials small by 83%, and from the large group trial by 81%.
Pemahaman Konsep Matematika Siswa Madrasah Tsanawiyah pada Statistika Ditinjau dari Gaya Belajar
Authors: Putri Alifia Nur Haliza , Sutrisno Sutrisno , Prasetyowati Dina
Published: July 2023

Understanding the concept is essential in learning mathematics, where it is possible to have different achievements based on the characteristics of students' learning styles. Therefore, this study wants to describe the ability to understand mathematical concepts in terms of students' learning styles. This qualitative research was conducted at MTs Negeri 2 Semarang. Of the 31 grade VIII students at the school, it was found that 42% had a visual learning style, 32% had an auditory learning style, and 26% had a kinesthetic learning style. Furthermore, research subjects were selected purposively based on mapping learning styles, and six students were obtained. Data collection techniques used learning style questionnaires, concept comprehension tests, and interviews. Data analysis techniques use interactive models and check the validity of the data using triangulation. Research data management and analysis using Nvivo software. The results showed no significant difference in conceptual understanding between subjects with visual, auditory, and kinesthetic learning styles. The six subjects can do the test correctly and have been confirmed through interviews. However, the two visual learning style subjects cannot show the location of the mean, median, and mode of data presented in the diagram. This finding suggests that teachers should emphasize using various mathematical representations in student learning.
Biodiversity of Migrant Birds in the Limboto Lake Region, Gorontalo Province
Authors: Ibrahim Mustamin , Husain Ilyas H. , Langaru Tutin Pratiwi
Published: July 2023

The bird population in Indonesia is rich in diversity, this is based on the number of bird populations and environmental conditions that are still maintained so as to allow the birds to live. This study aims to describe the types of migratory birds in Lake Limboto. The method used in this study is the count point method and with 4 observation points for 7 days on different days. The starting point of the observations is carried out alternately for each station so that there are variations in the observation time at each station. Overall, the classification of migratory birds in the Limboto Lake area is classified as moderate with an index carbon index value of 1.79. Migratory birds found in the Lake Limboto area are 9 species of migratory birds belonging to 7 families with a total of 706 individuals. The highest index value H'= 1.63 is at station 1, the diversity index value is moderate and the lowest hidden index H'= 0 is at station 4, the index value is relatively low.
The Gambler's Grind: Secrets of Success in the Casino
Authors: harris Huxley
Published: July 2023

The Gambler's Grind: Secrets of Success in the Casino" unveils the hidden strategies and techniques employed by successful gamblers to thrive in the fast-paced and unpredictable world of casinos. This book takes readers on a captivating journey, delving into the mindset, skills, and behaviors that contribute to a gambler's long-term success. From mastering popular games of chance to managing bankroll effectively, readers will gain valuable insights and practical tips to elevate their gambling experience and increase their chances of winning. "The Gambler's Grind" is a must-read for both novice and seasoned gamblers looking to enhance their skills and unlock the secrets to success in the casino.
RANCANG BANGUN SMS GATEWAY UNTUK TERIMA SMS PADA STASIUN RADIO RANSTRA FM
Authors: Subekti Rino
Published: July 2023

SMS gateway on Ranstra FM radio station is one application that can bridge the gap between mobile phones (mobile) by computers to be used to fulfill the programs associated with the delivery of SMS scales that require a lot more storage capacity as well as other programs, n this case as an example the issue is the program to send greetings and song requests in the event program Ranstra FM radio station. In this final project, the authors built an SMS gateway to receive an SMS on Ranstra FM radio stations with programming languages in use Visual Basic 6.0, and Microsoft Access as a database, and in order to run the SMS gateway MFBUS added a component. This application is expected to provide the ease of the "announcer" when aired (on-air)
Book Reviews
Authors: Cristofoletti Evandro Coggo , Aarnikoivu Melina
Published: July 2023

Amy J. Binder and Jeffrey L. Kidder (2022), The Channels of Student Activism: How the Left and Right are Winning (and Losing) in Campus Politics Today, Chicago: The University of Chicago Press, 225 pp., ISBN: 978-0-226-68427-7

Julia Molinari (2022), What Makes Writing Academic: Rethinking Theory for Practice, London: Bloomsbury Academic, 224 pp., ISBN: 978-1-3502-4392-7
Social Media and Youth Engagement in a Dynamic World: The Nigerian Perspective
Authors: Umuze N. Anthonia  , Edih O. University
Published: July 2023

Effects of globalization are reverberating across human endeavours in modern times and the social media being drivers of globalization are serving as veritable channels for transmitting information and communication from person to person, group to group and nation to nation as well as continent to continent. The unrestrained attitude of youth in the use of social media is rather contagious. It seems to demonstrate the indispensability and high premium placed on social media networks, maybe, due to the rewardable exercise derivable from social networking. Hence, the study seeks to examine social media and youth engagement in a dynamic world: the Nigerian perspective. The main objectives are to demonstrate the indispensable significance of the social media networks in a dynamic world and to secure or devise profitable measures of engaging the youths through the social media. The study is therefore, structured into six perspectives; introduction, general significance of the social media, effects of social media networks, the Nigerian perspective on the use of the social media, engaging the youth through social media, conclusion and recommendations.
Herramienta basada en optimización para reducir la temperatura superficial en circuitos electrónicos con transistores BJTs y MOSFETs en escenarios peligrosos
Authors: Collado Edwin , Delgado Jaime , Bernal Nieves , Cárdenas Dorindo , Sáez Yessica
Published: July 2023

El uso inadecuado de equipos electrónicos en áreas con alto riesgo de explosión es una de las principales causas de muertes y daños materiales en la industria. El objetivo de este trabajo es establecer un punto de operación óptimo que mejore el desempeño de circuitos electrónicos utilizando transistores de tecnología BJT o MOSFET que alimentan una carga en escenarios peligrosos. Para ello se aplica optimización convexa no lineal a la caracterización del comportamiento térmico de MOSFETs y BJTs en aplicaciones con alto riesgo de explosión. En este problema se utiliza como variable de decisión la corriente en el transistor y la temperatura límite en la superficie de los elementos eléctricos que genera la autoignición de gases, polvos, fibras combustibles u otros productos altamente inflamables almacenados en recintos clasificados como peligrosos. Esta variable de control permite trabajar en diferentes categorías de temperatura, considerando la clasificación de los niveles de riesgo térmico estandarizados por la industria de seguridad contra incendios. Además, se consideraron transistores que mantienen como restricción máxima la corriente nominal dada por el fabricante. Con esto es posible obtener un punto de trabajo adecuado que permita determinar los valores óptimos de las ecuaciones de comportamiento térmico para modelos específicos de MOSFETs y BJTs comúnmente utilizados en aplicaciones industriales. En el análisis matemático se utiliza el método Karush Kuhn Tucker (KKT) para resolver el problema propuesto y obtener las soluciones óptimas para los diferentes escenarios considerados. Con base en estas soluciones matemáticas, se propone un algoritmo para resolver el problema general de minimizar la temperatura superficial en transistores de manera rápida y eficiente mediante el control de la corriente en los transistores. Con este análisis de optimización es posible determinar un punto de operación térmica segura para el dispositivo que se encuentra operando en una instalación clasificada como peligrosa y al mismo tiempo manteniendo los niveles de tensión y corriente requeridos para la carga o señal que se necesita alimentar. o amplificado respectivamente.
The ethics of advancing artificial intelligence in healthcare: analyzing ethical considerations for Japan’s innovative AI hospital system
Authors: Katirai Amelia
Published: July 2023

Public and private investments into developing digital health technologies—including artificial intelligence (AI)—are intensifying globally. Japan is a key case study given major governmental investments, in part through a Cross-Ministerial Strategic Innovation Promotion Program (SIP) for an “Innovative AI Hospital System.” Yet, there has been little critical examination of the SIP Research Plan, particularly from an ethics approach. This paper reports on an analysis of the Plan to identify the extent to which it addressed ethical considerations set out in the World Health Organization’s 2021 Guidance on the Ethics and Governance of Artificial Intelligence for Health. A coding framework was created based on the six ethical principles proposed in the Guidance and was used as the basis for a content analysis. 101 references to aspects of the framework were identified in the Plan, but attention to the ethical principles was found to be uneven, ranging from the strongest focus on the potential benefits of AI to healthcare professionals and patients (n = 44; Principle 2), to no consideration of the need for responsive or sustainable AI (n = 0; Principle 6). Ultimately, the findings show that the Plan reflects insufficient consideration of the ethical issues that arise from developing and implementing AI for healthcare purposes. This case study is used to argue that, given the ethical complexity of the use of digital health technologies, consideration of the full range of ethical concerns put forward by the WHO must urgently be made visible in future plans for AI in healthcare.
Conservation Tillage in Medicinal Plant Cultivation in China: What, Why, and How
Authors: Hao Da-Cheng , Li Cheng-Xun , Xiao Pei-Gen , Xie Hong-Tu , Bao Xue-Lian , Wang Lian-Feng
Published: July 2023

Ecological cultivation is a promising regime for medicinal plant production. For a long time, unreasonable farming methods have threatened soil health and medicinal agriculture and restricted the sustainable development of ecological agriculture for medicinal plants. However, there is a lack of comprehensive discourse and discussion about the pros and cons of different tillage regimes. Here, the research trend and application prospects of no-tillage (NT) are comprehensively reviewed, and the ecological benefits, challenges, and opportunities of the NT system in ecological agriculture of medicinal plants are scrutinized, aiming to call for an about-face in the sustainable conservation and utilization of both phytomedicine resources and agricultural/ecological resources. An exhaustive literature search in PubMed, Bing, Scopus, and CNKI was performed to outline the research trend in conservation tillage and medicinal plants during the recent four decades. The application of NT has a long history and can reduce tillage frequency and intensity and protect soil from erosion and deterioration. NT is often combined with organic mulch to significantly reduce soil disturbance. NT and stover mulching have the advantages of saving manpower and resources and improving soil quality, crop yield, and quality. The ecological and economic benefits of NT in long-term medicinal plant cultivation could be prominent. In developing medicinal plant cultivation, competing with food crops should be avoided as much as possible, and the impact on the production of major grain crops should be minimized. Therefore, the full utilization of soil resources in forests, mountains, and wasteland is advocated, and sustainable soil utilization is the core issue in the process of land reclamation. NT and stover mulching not only inherit the traditional concept of “natural farming”, conform to the basic laws of ecology, as well as the growth characteristics of medicinal plants, but also protect the ecological environment of the production area. It would become the core strategy of ecological agriculture for medicinal plants. Our summary and discussions would help propose countermeasures to popularize NT and organic mulch, promote relevant research and scientific allocation of resources, and adapt to local conditions to achieve precise management and harmonize conservation and production of medicinal plants.
Pengaruh Rasio Etanol dan Air Cucian Surimi Ikan Gabus (Channa striata) Terhadap Recovery Protein Larut Air
Authors: Wiranata Nurhadi , Baehaki Ace , Lestari Susi
Published: July 2023

The objective of this research was to know the deposition of protein in snakehead fish (Channa striata) surimi wash water and know the effect of the ratio of ethanol and surimi wash water from snakehead fish (Channa striata) on the recovery of protein water solubility. Design was used with two factors of treatment which were repeated twice. The factors of treatment consist of surimi wash frequency and the addition of ethanol concentration. The parameters observed were water-soluble protein analysis and SDS-PAGE analysis. The highest precipitation in the treatment T2, while the lowest precipitation in treatment T0. Based on BJND test, every treatment showed different precipitated with other treatments. In each sample the water-soluble protein content (PLA) in the first washing is greater than the second washing. Based on BJND test, treatment T1, T2, and T3 were not different but significantly different with treatment T0 (without ethanol). The treatment effect of the ratio of ethanol and surimi wash water from snakehead fish effect on the percentage of water-soluble protein content. SDS-PAGE analysis showed treatment P1T0, P1T1, and P2T0 still contains albumin with a molecular weigh of 68.75 kDa. Results recovery of protein from the ratio effects of ethanol and snakehead fish surimi wash water from showed thet the use of ethanol is able to precipitate proteins. The use of ethanol is added to snakehead surimi wash water serves as a coagulant.
Desain Basis Data Website MyUnsri sebagai Media Informasi Dan Berbagi Pengetahuan Untuk Mahasiswa Universitas Sriwijaya
Authors: Abdul Haris Dalimunthe  , Iwan Pahendra Anto Saputra  , Desi Windi Sari  , Puspa Kurniasari  , Nadia Thereza  , Melia Sari
Published: July 2023

Website dapat berperan sebagai sarana untuk menyampaikan informasi seputar kegiatan akademis maupun non-akademis di Universitas Sriwijaya. Myunsri merupakan website yang dibentuk mahasiswa Universitas Sriwijaya yang bertujuan untuk berbagi pengetahuan dan informasi bagi mahasiswa Universitas Sriwijaya. Untuk menunjang kinerjanya, MyUnsri menggunakan basis data dengan tabel-tabel sebagai media penyimpanan datanya. Dengan demikian dibutuhkan perancangan basis data agar website dapat bekerja dengan semestinya. Tahapan yang dilakukan dalam perancangan basis data adalah dengan melakukan perencanaan, desain dan koding. Tahapan perencanaan adalah mengidentifikasi aktor dan aktivitas yang terkait dengan sistem yang akan dibuat. Setelah mengidentifikasi pada perencanaan dibuatlah suatu desain guna mengilustrasikan rancangan data yang akan dibuat. Tahapan terakhir adalah tahapan koding yang merupakan bentuk pengimplementasian dari desain data yang dibuat pada tahapan sebelumnya dimana pada tahapan ini digunakan perangkat lunak pengembangan basis data MySQL yang terintegrasi fitur phpMyAdmin sebagai alat bantunya
Evaluation on Prescribing Pattern of Antibiotics in Treating Respiratory Tract Infections with Who Core Drug Indicators
Authors: Melam Yesu Ratnam , K Sai Pradeep , P Srilekha , R Naresh
Published: July 2023

A respiratory tract infection (RTI) in defined as any infectious disease of the upper and lower respiratory tract Acute respiratory tract infection accounts for 12-39% of the in patients attendance in general hospital. A six months hospital based prospective observational study was carried out in the department of medicine at lalitha hospital, Guntur. The aim of the study was to analyse the prescribing patterns of antibiotic in respiratory tract infection at medicine department. The study results showed that out of 100 patients, more prevalent LRTI were 90 (90%) URTI were 10 (10%) The COPD, pneumonia, asthma were more prominent among LRTIs, whereas Pharyngitis and tonsilitis are prominent among URTI Results showed that for 100 patients 107 antibiotics were prescribed, most widely used antibiotics were penicillin+betalactam (38.31%). In our study the prescribers are relying upon higher antibiotics, this practise may lead to the antibiotic resistance and other complications of antibiotic resistance. Prescription analysis shows the way towards ratio use of drugs. Irrational drug use could also lead to ineffective and unsafe treatment and exacerbation and prolongation of illness, distress and harm to the patients. Hence prescription audit is necessary and the Clinical Pharmacist interventional programs should focus on promoting infections control with rational antibiotic prescription aimed at minimizing the future emergence of bacterial resistance. To overcome the irrational use of antibiotic, the study suggests the need of antibiotic prescribing guidelines for respiratory tract infections at the study site.