bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Associated with Antenatal Care Visit Dropout among Mothers attending Immunization Clinic
Authors: Subedi Sabitra , Mandal Punam K , Mahato Anju K , Basnet Bidhya , Rai Munawatee , Khadgi Deepika
Published: July 2024

Introduction: Developing nations continue to have high maternal mortality rates. Prenatal care helps to improve the mother's and the unborn child's health. The purpose of this study was to identify the variables linked to mothers' antenatal care visit dropout.
Methods: A cross-sectional study was carried out using the multi-stage sampling technique in the four urban and four rural randomly chosen municipalities of Morang district. In total, 134 postnatal mothers who skipped four focused ANC visits were chosen as study group and 266 postnatal mothers who completed four focused ANC visit from the same vaccination facilities were chosen as control group. Using a semi-structured questionnaire and the consecutive sampling approach, data were gathered through interviews. The final model was chosen by employing the backward elimination technique after doing bivariate and multivariate analysis.
Results: This study found that the majority (56.0%) of cases was from the age group of 21-30 years and 35.1% of cases were janajatis. The number of factors were linked to ANC dropout, including age (OR 2.49, 95% CI 1.07-5.82), ethnicity (OR 2.29, 95% CI 1.05-4.99), education (OR 4.64, 95% CI 1.99- 10.81), income (OR 3.49, 95% CI 1.75- 6.95), and the existence of complications (OR 1.15, 95% CI 0.54-2.44).
Conclusion: The risk factors for ANC dropout were age, ethnicity, education, income, and the presence of complications during previous pregnancy. It suggests that efforts should be made to spread the information about the value of four focused ANC visits.
Influence of Budgetary-Allocation on Performance of Projects within Non-Governmental Organizations in Mogadishu, Somalia
Authors: Abdikani Ali A , Ouma Caren A
Published: July 2024

This paper investigates the influence of budgetary allocation on performance of projects within Non-Governmental Organizations (NGOs) in Mogadishu, Somalia. Descriptive research design was used and the target population constituted 78 managers and 390 senior employees in 78 NGOs in Mogadishu. The study adopted a stratified random sampling technique by which a sample size of 216 respondents was chosen using Yamane’s (1967) formula. Data was collected using questionnaire, and both descriptive and inferential statistics were applied in the data analysis process. With regard to the influence of budgetary allocation on project management, the findings showed that employees agreed to a great extent that, proper budgetary control aid the NGOs in decision making, and majority consider budget knowledge as important for success in the workplace, looking at it as a means through which the company has can have a better understanding of budget control techniques. The result also showed that the intercept between budgetary allocation and performance of project becomes better by β = 0.821, p<0.01 confirming that when budgetary allocation is improved by a single unit, the project performance also significantly improves by 82.1%. The study made a conclusion that what cannot be measured therefore cannot be achieved. Projects that are able to generate revenues are likely to be funded through provision of proper budgets that support its operations.  The study recommends that all departments embrace budgeting and effective resource allocation for each function in the organization.
ASSOCIAÇÃO ENTRE A QUALIDADEDE DE SONO, NÍVEL DE ATIVIDADE FÍSICA, FUNÇÕES COGNITIVAS DE IDOSOS NA CIDADE DE UBÁ-MG
Authors: Garcia Izadora Nogueira , Zinato Sarah Semíramis do Amaral , Correa Alexandre Augusto Macedo , Camargos Gustavo Leite
Published: July 2024

Introdução: O sono é uma condição fisiológica, e um declínio da sua qualidade, principalmente na senescência pode acarretar prejuízos na vida do indivíduo, incluindo alterações cognitivas. Outro fator que pode impactar as funções mentais é a prática de exercício físico, pois já foi demonstrado que o mesmo é um importante estímulo para processos neurogênicos. Objetivo: O estudo teve como objetivo investigar a qualidade de sono, nível de atividade física e a função cognitiva de idosos na cidade de Ubá-MG. Metodologia: A amostra foi composta por 104 pessoas com média de idade de 67,63 (DP 7,05) anos, sendo 36 (34%) do sexo masculino e 70 (66%) do sexo feminino. Resultado: A maioria dos idosos avaliados apresentou indicativo de sono ruim ou com distúrbio, sendo os valores mais elevados encontrados para o grupo feminino, no entanto não houve associação entre o nível de atividade física e os aspectos cognitivos. Mesmo assim, foi identificado uma associação entre a prática de exercício físico e melhor indicativo na latência do sono. Ainda, aqueles que apresentaram maior prevalência de indicativo de disfunção cognitiva não praticavam exercício físico.
Parkinson Hastalığında Bilişsel Rehabilitasyon Yaklaşımları: Derleme
Authors: Gün Neslişah , Karcı Makbule
Published: July 2024

Parkinson hastalığı, sadece motor semptomlarla sınırlı kalmayan, aynı zamanda bilişsel fonksiyonları da etkileyebilen nörodejeneratif bir hastalıktır. Özellikle erken dönemde sıklıkla göz ardı edilen bu bilişsel etkilenimler, hastaların günlük yaşam aktivitelerini olumsuz etkiler. Hafif bilişsel bozukluktan demansa kadar uzanan geniş bir yelpazede ortaya çıkan bilişsel sorunlar hem hastalarda hem de bakıcılarda daha düşük yaşam kalitesi ile ilişkilidir. Bu nedenle Parkinson hastalığında bilişsel rehabilitasyon, bilişsel bozulma ile mücadelede kritik bir rol oynamaktadır. Bu rehabilitasyon yaklaşımları arasında egzersiz, bilişsel eğitim, bilişsel stimülasyon terapisi, gerçeklik yönelimi terapisi, anımsama terapisi, çift görev eğitimi, farkındalık temelli müdahaleler ve müzik terapi bulunmaktadır. Bu yöntemler, hafıza, dikkat, yürütücü fonksiyonlar gibi bilişsel alanlarda iyileşmeye katkı sağlamaktadır. Bilişsel rehabilitasyonun erken dönemde uygulanması, hastalığın seyrini yavaşlatmanın yanı sıra bakım verenlerin tükenmişliğini önleme veya hafifletme açısından önemlidir. Bu derlemenin amacı Parkinson hastalığında bilişssel rehabilitasyon kapsamında kullanılan yöntemleri literatür ışığında incelemektir.
Göğüs ve Kalp Cerrahisi Sonrası Komplikasyonlar ve Bu Komplikasyonların Hemşirelik Bakım Kalitesi Algısı Üzerindeki Etkisi
Authors: Yıldız Fındık Ümmü , Soydaş Duygu , Gökce Işıklı Ayşe
Published: July 2024

Arka plan: Hemşireler perioperatif dönemde hasta güvenliğini sağlar. Ancak, ameliyat sonrası komplikasyon riski vardır ve ameliyat sonrası komplikasyonların iyileşme süreci gibi birçok konuda olumsuz etkileri vardır.
Amaçlar: Bu çalışma, göğüs ve kalp cerrahisi sonrası komplikasyonları ve bu komplikasyonların hastaların hemşirelik bakım kalitesi algıları üzerindeki etkisini belirlemeyi amaçlamaktadır.
Yöntemler: Bu çalışma Bu çalışma, Mayıs 2017-Mayıs 2019 tarihleri arasında Türkiye'de 103 hasta ile kesitsel bir çalışma olarak gerçekleştirildi. Veriler ameliyat sonrası 4. veya 5. günde hasta bilgi formu, komplikasyon kontrol formu ve Bakım Davranışları Envanteri-24 (CBI-24) kullanılarak toplandı.
Bulgular: Hastaların %49,5'inde ameliyat sonrası komplikasyon geliştiği, bunların en sık kalp ritim bozuklukları ve basınç yaralanmaları olduğu tespit edilmiştir. Komplikasyon yaşayan hastaların ortalama CBI-24 skorları, komplikasyon yaşamayan hastalarınkinden istatistiksel olarak anlamlı derecede yüksekti.
Sonuçlar: Sonuçlar, hastaların yaklaşık yüzde 50'sinin komplikasyon yaşadığını; en sık görülen komplikasyonların kalp ritim bozuklukları ve basınç yaralanması olduğunu ve komplikasyon yaşayan hastaların hemşirelik bakım kalitesi algısının diğer hastalara göre daha yüksek olduğunu göstermektedir. Göğüs ve kalp ameliyatları sonrası komplikasyonların azaltılması için hastaların bakım ve tedavilerinde iyileştirmelere ve bu konuda bilimsel çalışmalara ihtiyaç vardır. Hemşirelerin göğüs ve kalp cerrahisi sonrası komplikasyonları önlemek için hastaya özgü önlemler almalarını öneriyoruz.
Estimate of Temperature Rise in the 21st Century for Various Scenarios
Authors: Donald Rapp
Published: July 2024

The International Panel on Climate Change (IPCC) published a lengthy report on climate change in early 2023. This report hypothesizes five potential scenarios of greenhouse gas emissions from 2015 to the end of the century (2100) and estimates the global average temperature gain in the year 2100 from the mid-1800s for each scenario. The method of calculation in the IPCC report is obscure. The results are merely stated. The present paper provides a clear method for estimating the temperature gain each year from 2015 until 2100, along with yearly estimates of ppm of CO2. To facilitate the calculations, a set of scenarios of future emissions was chosen that is analogous to the scenarios used by the IPCC but is more amenable to computation. The basic assumption in this paper is that most of the temperature gain from the mid-1800s to 2015 (1.15 C – as reported by the IPCC) was due to rising CO2 concentration in the atmosphere and a relationship is thereby derived between warming and gigatons of CO2 emitted for the period: 1800s to 2015. If it is assumed that the amount of warming per gigaton CO2 from the past persists into the 21st century, then future warming in the 21st century can be estimated for any assumed future scenario of CO2 emissions. This paper provides a simple and clear estimate of yearly CO2 ppm and temperature rise from 2015 to 2100 since the 1800s for a set of scenarios that cover the likely range of future emissions.
Analisis Faktor-Faktor yang Mempengaruhi Kinerja Keuangan Sektor Perbankan di Bursa Efek Indonesia
Authors: Uli Evita , Siyo Kasim
Published: July 2024

The purpose of this study is to determine the partial to simultaneous influence of Capital, Asset, Management, Earnings, Liquidity variables as well as sensitivity to market risk on Return on Assets (ROA). This research was conducted on Banking Sector companies listed on the Indonesia Stock Exchange. The research approach uses quantitative research. The total population in this study is 46 banking companies that have entered and listed stocks during the observation period of 2018-2022, which is 5 years. The company met the sample withdrawal criteria, namely the entire population of 40 companies, so the sample in this study was 40 x 5 = 200 financial statements. The analysis tool in this study is Eviews version 13. The data analysis technique uses panel data regression analysis. The results of his research show that partially CAR has a significant positive effect on ROA. NPLs have no positive and insignificant effect on ROA. LDR has a significant positive effect on ROA. BOPO has a significant positive effect on ROA. PDN had a significant positive effect on ROA and NPM had no positive and insignificant effect on ROA. Meanwhile, simultaneously the variables CAR, NPL, LDR, BOPO, PDN and NPM simultaneously had a significant positive influence on ROA. The contribution of all variables was 53.30%.
Hubungan Status Gizi Dengan Gangguan Siklus Menstruasi Pada Remaja Putri SMAN 13 Makassar
Authors: Irmawati S.  , Riska Sari  , Musfira Aziz
Published: July 2024

Nutritional status affects the menstrual cycle. If a woman with a nutritional status is thin, fat tissue which is also a source of low estrogen will produce low estrogen, causing disruption to the menstrual cycle by looking at the relationship between nutritional status and menstrual cycle disorders in young women at Sman 13 Makassar. This research uses an observational analytical research design with a cross-sectional approach. Purposive sampling was used to determine the sample size. The data analysis technique uses the chi square test and ordinal regression
Re-proposing Cultural Based Curriculum System of Tamansiswa as the National Education Foundation in Indonesia
Authors: Rizki Ramadhan
Published: July 2024

The  problems  faced  by  the  Indonesia  educational  system should  have  been  examined  deeply  as  it  seems  difficult  to  apply  an educational system that can be implemented effectively. This issue can be seen from the number of curriculum changes recently. Considering that problems, developing educational system based on its own nation culture  will  be  considered  to  be  more  effective  in  order  to  build  the characters of the students. By developing Ki Hadjar Dewantara’s idea with  his  system,  the  educational  system  in  Indonesia  will  be  more practical  and  suitable,  since  this  idea  has  been  admitted  as  modern thought or ideas which will give a lot of beneficial for the learners.
Identification of Tropical Freshwater Eels, Anguilla spp., in Cagayan River, Philippines
Authors: Hilario Joyce ,   Bureau of Fisheries and Aquatic Resources-National Freshwater Fisheries Technology Center, Science City of Muñoz, Nueva Ecija, Philippines, Choresca Casiano Jr , Dantinga Ma. Jodecel , Magbanua Faith Loraine , Oclos Ma. Theresa ,   National Fisheries Research and Development Institute-Fisheries Biotechnology Center, Science City of Muñoz, Nueva Ecija, Philippines
Published: July 2024

Anguillid eels are high-value food fish with 16 known species worldwide. Due to its taxonomic ambiguity and insufficient data on species composition, this family of freshwater eels were inadvertently regarded as a single species. This study collected 63 freshwater eels at 3 life stages (glass eel, elver, yellow eel) from Cagayan River, Philippines, to evaluate the accuracy of morphological identification in comparison with molecular analysis. Morphological results displayed clear distinctiveness between Anguilla bicolor and Anguilla marmorata despite some overlapping physical characteristics between Anguilla marmorata and Anguilla luzonensis. Phylogenetic analysis revealed that 15 out of 23 glass eel specimens were molecularly identified as A. marmorata, while 8 were identified as A. bicolor pacifica. For elver specimens, there were A. bicolor pacifica (n = 10), A. marmorata (n = 8), and A. luzonensis (n = 2). For yellow eels, there were A. bicolor pacifica (n = 10) and A. marmorata (n = 10). The results showed the inaccuracy of morphological identification in determining the richness and composition of Anguillids, which otherwise proved that molecular analysis is a more reliable approach in identifying freshwater eel species.
Uruguai Em direção à educação inclusiva
Authors: Sena Alejandra Elizabeth Vergara , Selau Bento
Published: July 2024

Este artigo tem como objetivo apresentar como a educação inclusiva se desenvolveu no Uruguai. Realizaremos uma descrição do sistema formal educativo uruguaio e seus diferentes órgãos, detendo-nos no Conselho de Educação Técnica Profissional. Logo, nos antecedentes históricos e atuais da educação inclusiva e seu marco normativo.
ORGANIZED PATHS OF SELF-EDUCATION FOR YOUTH
Authors: Rzayeva Nurəngiz
Published: July 2024

The scientific article consistently explains ways to organize self-education for adolescents. The article discusses the directions of organizing self-education. The article states that one of the most important features of self-education is the development of self-confidence. Self-control is realized through conscious and focused attention. Self-awareness means self-discipline. Also in the article, in the form of a table, a number of exercises are presented to stimulate the process of self-education of adolescents.
Transport Service Website
Authors: Kawale Sakshi
Published: July 2024

Abstract— ShipEx Transport is an awesome website that offers a wide range of shipping services.They specialize in transporting goods by ship, providing efficient and reliable solutions for both domestic and international shipping needs. Whether you need to transport large cargo or small packages, ShipEx has got you covered. Their website provides all the information you need about their services, including rates, tracking options, and customer reviews. It’s a convenient and trustworthy platform for all your shipping needs.
TRAINTICKET RESERVATION SYSTEM
Authors: Tekade Bhushan P.
Published: July 2024

Abstract: Th This research paper presents the design and implementation of a Train Ticket Reservation System using Java, aiming to streamline the process of booking train tickets for passengers. The system leverages object-oriented programming principles and Java technologies to provide a user-friendly interface for booking, canceling, and managing train tickets. Through a detailed description of the system architecture, database design, and user interactions, this paper demonstrates the functionality and effectiveness of the Train Ticket Reservation System in facilitating smooth and efficient ticket booking operations. Keywords- Train schedule, Seat availability, Booking, Reservation, Ticketing, Passenger information, Payment processing, Seat selection, Confirmation.
Вступ до Map Waprer
Authors: Пікон Родріґес Антоні , Куадрос Міґель , Назарук Тарас , Корман Олександр
Published: July 2024

Заняття ознайомлює з основами використання Map Warper для історичних карт - від завантаження до експорту, демонструючи методи географічної прив’язки (геоприв’язки) та створення візуалізацій.
Espaço rizomático de Vasto Mar de Sargaços
Authors: Freitas Viviane
Published: July 2024

Este trabalho faz uma abordagem da cartografia rizomática de Vasto Mar de Sargaços da escritora caribenha Jean Rhys, a partir da sua estrutura marcadamente polifônica, definida não só pelo jogo intertextual que estabelece com o romance Jane Eyre de Charlotte Brontë, mas pela sua estrutura narrativa. O capítulo explora as formas pelas quais a topografia ficcional é construída através da inter-relação entre o tempo-espaço de Jane Eyre e o tempo-espaço de Vasto Mar de Sargaços, e definida pela pluralidade de vozes e discursos que se justapõem, e se contrapõem na narrativa do romance caribenho. O trabalho examina a maneira como a “espacialização da história” da personagem Bertha Mason em Vasto Mar de Sargaços, permite uma releitura da visão colonial endossada pelo texto de Charlote Brontë. Vasto Mar de Sargaços revela a alteridade que foi suprimida no romance Jane Eyre, ao trazer à tona a espacialidade caribenha enquanto dimensão da experiência humana. É essa dimensão espacial, feita da matéria própria da vida, que, no entanto, sempre escapa à representação, que Rhys explora em sua ficção. A história espacial desafia as imaginações míticas do objeto da história imperial, legitimada por um discurso lógico, coerente. Em contraste com a visibilidade da história imperial, está a invisibilidade do objeto da história espacial, a dimensão do vivido e experimentado, uma história composta por traços, vestígios de espaços. A história espacial começa e termina na linguagem, pois através da linguagem o espaço é simbolicamente transformado em um espaço com uma história.
Fabulações da diáspora: análise de possíveis diálogos entre o romance “Os estandartes” (1995), de Aline França, e a HQ “Black Panther: who is the Black Panther?” (2014) do roteirista Reginald Hudlin e desenhista John Romita Jr
Authors: Damasceno Daniela dos Santos
Published: July 2024

Por muito tempo a literatura brasileira esteve ligada as ideologias dominantes e privilegiadas. Desta forma, na sua maioria, as produções literárias brasileiras proliferaram estereótipos e mitos que contribuíram para reprodução da imagem negativa do negro e da sua cultura. No entanto, constituindo-se inversamente às ideologias europeias, a literatura negra surge como forma de (re) apresentar, (re) nomear, (re) posicionar e representar o mundo negro, a partir de um eu enunciador que fala não apenas do outro, mas também de si mesmo. A partir deste cenário, este artigo tem como objetivo analisar as fabulações da diáspora que revelam o desejo de construir outro mundo, operando por utopias, na medida em que centraliza o homem negro e a sua (s) cultura (s), lançando um olhar ao que está posto e ao que poderia ser. Portanto, toma como base o método comparatista para a elaboração de possíveis diálogos entre a HQ “Black Panther: who is the Black Panther?” (2014), dos autores Reginald Hudlin e John Romita Jr, e o romance “Os Estandartes” (1995), de Aline França. Ademais, tenta identificar possíveis utopias presentes na sociedade dos Fortiafri e no reino fictício de Wakanda, propondo uma reflexão acerca da reinvenção da(s) África(s) e da reparação histórica a todos os territórios e populações negras espoliadas pelo racismo e intolerância em todo o mundo.
Plano de aula de inglês: uma análise a partir da necessidade adequação ao contexto das escolas no campo
Authors: Bispo Célia
Published: July 2024

Este trabalho objetiva sintetizar as análises de planos de aula de língua inglesa em escolas públicas de três diferentes zonas rurais da Bahia. O objetivo da análise foi investigar se os conteúdos e objetivos apresentados em tais planos foram adequados a uma proposta de ensino que considere o contexto regional de tais escolas. Para isso foram analisados planos de três escolas, dez de cada uma, totalizando trinta amostras.
Folclore ucraniano em duas narrativas de Gógol
Authors: Bittencourt Rodrigo do Prado
Published: July 2024

Este artigo analisa duas novelas de Gógol: “Noite de Natal” e “Viy”. Os dois textos têm características de narrativa folclórica e descrevem a ação de seres sobrenaturais e acontecimentos extraordinários. A vida nas pequenas aldeias ucranianas, descrita por Gógol, pauta-se na independência típica dos cossacos e no gozo dos prazeres. Além disso, há a integração social das mais diversas personagens, mesmo das bruxas. Trata-se de outra realidade, bem distante daquela formada pelo capitalismo moderno e pela moralidade cristã tradicional.
Urban scenarios in Walt Whitman’s poetry
Authors: Satorno Marla Do Vale
Published: July 2024

One of the most striking features in 19th century poetry is the scenes of astonishing industrial progress, the development of the cities, the people who rush around, either working or just living their lives. Such urban scenarios are constant images in poems of this period. American poet Walt Whitman is also one of the poets who conveys urban movement through his poetry. With these characteristics as a starting point, the purpose of this article is to focus on the urban images in Whitman’s poetry, analyzing the poetry of the cities. Closely linked to Baudelaire’s flâneur, Whitman also observes city life from a contemplative point of view. In poems like City of Ships, I Hear America Singing, Crossing the Brooklyn Ferry, among others, Whitman sings of city life, its constant movement, its people and its landscapes. Focusing on the poet’s observation of urban life in the nineteenth century, this article also intends to make a link between the 19th Century idea of modernity and Whitman’s poems. A small selection of poems from Leaves of Grass which highlights these characteristics was chosen to be the focus of this analysis.
Tradução como atividade de desenvolvimento da criticidade em sala de aula de língua estrangeira
Authors: Rezende Patrick
Published: July 2024

Este trabalho objetiva contribuir com vozes que desconstroem a persistente ideia de tradução como atividade mecânica e neutra que transfere significados supostamente estáveis de uma determinada língua para outra. Entendendo a tradução como uma tarefa altamente subjetiva, e, portanto, ideológica, apresentaremos a atividade tradutória como vetor possível para o desenvolvimento do pensamento crítico dos alunos de língua estrangeira ao refletirmos sobre as possibilidades de produção de sentido via tradução.
Mundo de Wakanda e seu rei: análises
Authors: Damasceno Daniela dos Santos
Published: July 2024

Acerca da discussão da participação do negro nos diversos sistemas da sociedade, ainda há muitas trilhas possíveis. A arte dos quadrinhos pode servir como uma das trilhas, inclusive de artistas preocupados com as questões étnico-culturais. Muitos, negros ou negras ou não-negros, que refundam imaginários e personagens. Esta pesquisa consiste em um recorte temático de um projeto maior intitulado “Olhos de Pantera: o reino de Wakanda como heterotopia na contemporaneidade”. Nesta pesquisa, optou-se por analisar o super-herói Pantera Negra que, embora seja um dos mais influentes da Marvel, é pouco explorado: compreender o estereótipo sobre o negro e seu espaço ancestral a partir de representações de um super herói africano na HQ Black Panther: who is the Black Panther? (2014), de Reginald Hudlin e Romita Jr. A obra escolhida constitui o cenário da pesquisa. Os personagens negros da narrativa, em especial o super-herói Pantera Negra e o seu espaço ancestral, o denominado país fictício Wakanda, constituem-se como os principais sujeitos da mesma. Portanto, buscou-se respostas para as seguintes questões: Como a análise de obras como Black Panther: who is the Black Panther?, de Reginald Hudlin e Romita Jr, e outros textos a elas filiados, podem avultar reflexões acerca da ancestralidade, tradições e culturas negras? Sublinham a história factual de luta e desmistificam contemporaneamente a imagem de subalternidade dos negros? De que maneira é possível demarcar estereótipos do super-herói negro Pantera Negra como protagonista da HQ e do seu espaço ancestral Wakanda?. Para isto, recorreu-se a autores, como: Gianni Vattimo (1990), Michel Foucault (1984; 1988), Alex de Barros Cassal (2001), Pereira (2002), dentre outros que se fizeram pertinentes à compreensão de categorias conceituais e teóricas a saber: heterotopia, representação, herói, estereótipos como também para demais análises.
Desvendando Alice: uma análise psicanalítica do país das maravilhas
Authors: Oliveira Flávia Cristina Martins
Published: July 2024

Este artigo surgiu das inquietações da autora durante a leitura da história Alice no País das Maravilhas. Lewis Carroll, ao apresentar o mundo onírico de Alice, convida o leitor a entrar no mais íntimo dela, e assim mergulhar no sonho dessa menina curiosa, valente e determinada. Com o aprofundamento das bases psicanalíticas por parte da autora, surgiu a oportunidade de analisar essa obra à luz da teoria freudiana. Freud, com sua obra A Interpretação dos Sonhos, consegue provar a existência do inconsciente. Com isso, ele prova que existe mais no sujeito do que somente a parte consciente. Tudo o que é vivido, experenciado, afeta o sujeito psiquicamente, estando ele sempre em constante construção. Acordados, os sujeitos usam o ego e o superego para realizar suas funções diárias. Ao dormir, sonha para liberar o id, aliviando as pressões e dando vazão ao inconsciente. Durante a análise da obra, Alice em suas aventuras oníricas, vê-se perdida em um mundo estranho e que se esforça para compreender. Ao longo da história ela vai se fortalecendo, posicionando-se em relação ao que quer fazer e dizer. Percebe-se uma consolidação de sua estrutura psíquica ao se deparar com os outros personagens. É no encontro com seu inconsciente que ela se torna decidida e valente.
Frustração e nostalgia em dois romances de Joseph Roth
Authors: Vilela Marcos Antonio Maia
Published: July 2024

A referência a um passado distante e o tom saudosista diante do presente marcam dois textos ficcionais de Joseph Roth: Marcha de Radetzky e A Cripta dos Capuchinhos, publicados respectivamente em 1932 e 1938. A força nostálgica é uma das chaves para a compreensão da escrita de Roth, conforme destaca Luis Krausz. Neste artigo, buscou-se estabelecer uma análise comparativa entre os dois romances com o intuito de sublinhar a imagem de família associada à existência do Império Austro Húngaro em seus estertores e consequente colapso após a Primeira Guerra. Com este objetivo, os textos de Hermann Broch (2014), Bernhard Jankowsky (1978), Luis Krausz (2006, 2014) e Stefan Zweig (2013) serviram de apoio à análise.
Mitos del amor romántico y sexismo ambivalente en adolescentes
Authors: Martín Cabrera Eduardo , Torbay Betancor Ángela , Alonso Sánchez José Alexis
Published: July 2024

El objetivo de este trabajo fue analizar la prevalencia del sexismo y de los mitos del amor romántico entre los adolescentes, así como la relación entre ambas variables y su estabilidad en función de la edad. 900 adolescentes de centros públicos, de los que el 53.4 % eran chicas entre 13 y 17 años, con una media de 15.2, cumplimentaron el Inventario de Sexismo Ambivalente y la Escala de Mitos hacia el Amor. Los principales resultados señalaron que las puntuaciones difieren entre chicos y chicas, especialmente en el caso del sexismo, variable en la que las puntuaciones de los chicos fueron muy superiores a la de las chicas. En relación con los mitos del amor romántico, las chicas puntuaron más alto en los mitos relacionados con la idealización del amor, y los chicos en los que vinculan amor y maltrato. Se encontraron diferencias de género en la relación que mantienen ambas variables entre sí, y con la edad, aunque la prevalencia no varía mucho con el paso del tiempo. Se concluyó que factores como el consumo de pornografía, la proliferación de ideas negacionistas de la violencia de género y la ausencia de una educación afectivosexual adecuada, podrían estar detrás de estos resultados. Parece necesario implementar acciones, desde todos los ámbitos, para lograr que los y las adolescentes interioricen valores igualitarios.
Association with TFIIIC limits MYCN localization in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA Polymerase II
Authors: Vidal Raphael , Leen Eoin , Herold Steffi , Müller Mareike , Fleischhauer Daniel , Schülein-Völk Christina , Papadopoulos Dimitrios , Röschert Isabelle , Uhl Leonie , Ade Carsten P , Gallant Peter , Bayliss Richard , Eilers Martin , Büchel Gabriele
Published: July 2024

MYC family oncoproteins regulate the expression of a large number of genes and broadly stimulate elongation by RNA polymerase II. While the factors that control the chromatin association of MYC proteins are well understood, much less is known about how interacting proteins mediate MYC’s effects on transcription. Here we show that TFIIIC, an architectural protein complex that controls the three-dimensional chromatin organization at its target sites, binds directly to the amino-terminal transcriptional regulatory domain of MYCN. Surprisingly, TFIIIC has no discernible role in MYCN-dependent gene expression and transcription elongation. Instead, MYCN and TFIIIC preferentially bind to promoters with paused RNAPII and globally limit the accumulation of non-phosphorylated RNAPII at promoters. Consistent with its ubiquitous role in transcription, MYCN broadly participates in hubs of active promoters. Depletion of TFIIIC further increases MYCN localization to these hubs. This increase correlates with a failure of the nuclear exosome and BRCA1, both of which are involved in nascent RNA degradation, to localize to active promoters. Our data suggest that MYCN and TFIIIC exert an censoring function in early transcription that limits promoter accumulation of inactive RNAPII and facilitates promoter-proximal degradation of nascent RNA.
Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure
Authors: Passlick Stefan , Ullah Ghanim , Henneberger Christian
Published: July 2024

Ischemia leads to a severe dysregulation of glutamate homeostasis and excitotoxic cell damage in the brain. Shorter episodes of energy depletion, for instance during peri-infarct depolarizations, can also acutely perturb glutamate signaling. It is less clear if such episodes of metabolic failure also have persistent effects on glutamate signaling and how the relevant mechanisms such as glutamate release and uptake are differentially affected. We modelled acute and transient metabolic failure by using a chemical ischemia protocol and analyzed its effect on glutamatergic synaptic transmission and extracellular glutamate signals by electrophysiology and multiphoton imaging, respectively, in the hippocampus. Our experiments uncover a duration-dependent bidirectional dysregulation of glutamate signaling. Whereas short chemical ischemia induces a lasting potentiation of presynaptic glutamate release and synaptic transmission, longer episodes result in a persistent postsynaptic failure of synaptic transmission. We also observed unexpected differences in the vulnerability of the investigated cellular mechanisms. Axonal action potential firing and glutamate uptake were unexpectedly resilient compared to postsynaptic cells, which overall were most vulnerable to acute and transient metabolic stress. We conclude that even short perturbations of energy supply lead to a lasting potentiation of synaptic glutamate release, which may increase glutamate excitotoxicity well beyond the metabolic incident.
Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
Authors: Zhang Youyou , Xu Mu , Yuan Jiao , Hu Zhongyi , Jiang Junjie , Huang Jie , Wang Bingwei , Shen Jianfeng , Long Meixiao , Fan Yi , Montone Kathleen T , Tanyi Janos L , Tavana Omid , Chan Ho Man , Hu Xiaowen , Zhang Lin
Published: July 2024

An “induced PARP inhibitor (PARPi) sensitivity by epigenetic modulation” strategy is being evaluated in the clinic to sensitize homologous recombination (HR)-proficient tumors to PARPi treatments. To expand its clinical applications and identify more efficient combinations, we performed a drug screen by combining PARPi with 74 well-characterized epigenetic modulators that target five major classes of epigenetic enzymes. Both type I PRMT inhibitor and PRMT5 inhibitor exhibit high combination and clinical priority scores in our screen. PRMT inhibition significantly enhances PARPi treatment-induced DNA damage in HR-proficient ovarian and breast cancer cells. Mechanistically, PRMTs maintain the expression of genes associated with DNA damage repair and BRCAness and regulate intrinsic innate immune pathways in cancer cells. Analyzing large-scale genomic and functional profiles from TCGA and DepMap further confirms that PRMT1, PRMT4, and PRMT5 are potential therapeutic targets in oncology. Finally, PRMT1 and PRMT5 inhibition act synergistically to enhance PARPi sensitivity. Our studies provide a strong rationale for the clinical application of a combination of PRMT and PARP inhibitors in patients with HR-proficient ovarian or breast cancer.
Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition
Authors: Wang Liyi , Liu Shiqi , Zhang Shu , Wang Yizhen , Zhou Yanbing , Shan Tizhong
Published: July 2024

Conjugated linoleic acids (CLAs) can serve as a nutritional intervention to regulate quality, function and fat infiltration in skeletal muscles but the specific cytological mechanisms are still unknown. Here, we applied single-nucleus RNA-sequencing (snRNA-seq) to characterize the cytological mechanism of CLAs regulates fat infiltration in skeletal muscles based on pig models. We investigated the regulatory effects of CLAs on cell populations and molecular characteristics in pig muscles and found CLAs could promote the transformation of fast glycolytic myofibers into slow oxidative myofibers. We also observed three subpopulations including SCD
+
/DGAT2
+
, FABP5
+
/SIAH1
+
, and PDE4D
+
/PDE7B
+
subclusters in adipocytes and CLAs could increase the percentage of SCD
+
/DGAT2
+
adipocytes. RNA velocity analysis showed FABP5
+
/SIAH1
+
and PDE4D
+
/PDE7B
+
adipocytes could differentiate into SCD
+
/DGAT2
+
adipocytes. We further verified the differentiated trajectory of mature adipocytes and identified PDE4D
+
/PDE7B
+
adipocytes could differentiate into SCD
+
/DGAT2
+
and FABP5
+
/SIAH1
+
adipocytes by using high IMF content Laiwu pig models. The cell-cell communication analysis identified the interaction network between adipocytes and other subclusters such as fibro/adipogenic progenitors (FAPs). Pseudotemporal trajectory analysis and RNA velocity analysis also showed FAPs could differentiate into PDE4D
+
/PDE7B
+
preadipocytes and we discovered the differentiated trajectory of preadipocytes into mature adipocytes. Besides, we found CLAs could promote FAPs differentiate into SCD
+
/DGAT2
+
adipocytes via inhibiting c-Jun N-terminal kinase (JNK) signalling pathway
in vitro
. This study provides a foundation for regulating fat infiltration in skeletal muscles by using nutritional strategies and provides potential opportunities to serve pig as an animal model to study human fat infiltrated diseases.
Secretomic changes of amyloid beta peptides on Alzheimer’s disease related proteins in differentiated human SH-SY5Y neuroblastoma cells
Authors: Roytrakul Sittiruk , Jaresitthikunchai Janthima , Phaonakrop Narumon , Charoenlappanit Sawanya , Thaisakun Siriwan , Kumsri Nitithorn , Arpornsuwan Teerakul
Published: July 2024

Alzheimer’s disease (AD) is a neurodegenerative disease that causes physical damage to neuronal connections, leading to brain atrophy. This disruption of synaptic connections results in mild to severe cognitive impairments. Unfortunately, no effective treatment is currently known to prevent or reverse the symptoms of AD. The aim of this study was to investigate the effects of three synthetic peptides, i.e., KLVFF, RGKLVFFGR and RIIGL, on an AD in vitro model represented by differentiated SH-SY5Y neuroblastoma cells exposed to retinoic acid (RA) and brain-derived neurotrophic factor (BDNF). The results demonstrated that RIIGL peptide had the least significant cytotoxic activity to normal SH-SY5Y while exerting high cytotoxicity against the differentiated cells. The mechanism of RIIGL peptide in the differentiated SH-SY5Y was investigated based on changes in secretory proteins compared to another two peptides. A total of 380 proteins were identified, and five of them were significantly detected after treatment with RIIGL peptide. These secretory proteins were found to be related to microtubule-associated protein tau (MAPT) and amyloid-beta precursor protein (APP). RIIGL peptide acts on differentiated SH-SY5Y by regulating amyloid-beta formation, neuron apoptotic process, ceramide catabolic process, and oxidative phosphorylation and thus has the potentials to treat AD.
Dostoievski ante la cruz. Una lectura de El idiota a partir del “Cristo muerto” de Holbein
Authors: González Miguel
Published: July 2024

En el presente trabajo se propone una lectura de El idiota, de Dostoievski, a partir del pasaje en que el príncipe Myshkin junto a Rogozhin contemplan el cuadro Cristo muerto de Hans Holbein, el joven. Esta escena resulta premonitoria con respecto al destino de Myshkin, quien después de darlo todo por los demás, termina perdiendo la razón, transformándose así, tal como el Cristo de Holbein, en una imagen desfigurada de Jesús.
Design and Implementation of Computeraided Learning Module in Pharmacology for Vasoactive Drugs: An Experience from a State Medical College in Haryana, India
Authors: Kairi Jayant Kumar , Sharma Nitika
Published: July 2024

Introduction: In the Competency-based Medical Education (CBME) curriculum, one of the core competencies involves demonstrating the effects of autonomic drugs. It is a skill competency, and students have to learn to demonstrate the acquisition of this competency in a skill lab. Computer-aided demonstrations can enhance the teaching-learning experience and fulfill the learning objectives related to the effects of vasoactive drugs. Aim: To design and evaluate a Computer-aided Learning (CAL) module to teach the effects of vasoactive drugs. Materials and Methods: The study, being a curriculum implementation project, was conducted using a mixed methods study design at Kalpana Chawla Govt. Medical College, Karnal, Haryana, India over a period of one year from October 2020 to October 2021. Here, the impact of the intervention was measured through a multiple-choice quiz on the topics learned through CAL. The study population included all students undergoing the Phase-2 stage of the MBBS course at our institute. For skill acquisition in the cognitive domain, a video bank in the computer lab was made available to 120 undergraduate medical students. During practical training, in small groups, the training videos and animations were played, showing the effects of selected common vasopressors, vasodepressors, and their antagonists to the students. Simulated experiments on vasoactive drugs were shown to the students using ExPharm software (Free version). The achievement of learning objectives was assessed through a quiz. The perception of the students toward the new method was assessed through a questionnaire, and that of the faculty was evaluated with a Focused Group Discussion (FGD). Simple descriptive statistics, specifically the mean and standard deviation, were used to generate results. Results: All the students who participated in providing feedback on the module 113 (100%) had used CAL-based learning to acquire the skills. 60.7% of students (n=68) used both the animation and simulation components of the CAL to achieve proficiency in learning about vasoactive drugs. All teachers (n=5, 100%) during the FGD expressed satisfaction with the development and outcomes of the learning module, while highlighting the need for better CAL devices and methods. Conclusion: The CAL module developed for teaching and learning the effects of vasoactive drugs in experimental pharmacology was considered to be just about satisfactory
Cone Beam Computed Tomography Evaluation of Median Mandibular Lingual Canal in a Western Indian Subpopulation: A Cross-sectional Study
Authors: Venkatesh Rashmi , Badi Kavita , Shah Palak H , More Chandramani B
Published: July 2024

Introduction: The Mandibular Lingual Canals (MLC), which carry the sublingual artery, are present in the mandible near the genial tubercle. Identification of these canals is important before any dental surgical procedures. Aim: To identify and evaluate the mandibular lingual canal in Cone Beam Computed Tomography (CBCT) of the Western Indian Population. Materials and Methods: The current cross-sectional study was conducted at the Department of Oral Medicine and Radiology, Sumandeep Vidyapeeth, Vadodara, Gujarat, India between October 2022 and June 2023. A total of 100 CBCT volumes showing the mandibular anterior region were evaluated for the presence or absence of a mandibular lingual canal. The canals were further evaluated for their number, diameter, length, thickness of the buccal cortical plate, and the remaining bone above and below the canal. The evaluation was done by two separate investigators. The data were entered into Microsoft Excel and subjected to statistical analysis. Data collected were tested statistically using the Chi-square test. Results: A total of 59 males and 41 females’ mandibular CBCT volumes were evaluated, out of which 93 CBCT volumes showed the mandibular lingual canal. The maximum number (n=57) of individuals showed three canals, followed by two canals (n=26) and one canal (n=10). There was no statistical significance between genders regarding canal number, diameter, length, thickness of the buccal cortical plate, and the remaining bone above and below the canal. Conclusion: Three-canal morphology was the most common anatomical form of MLC found in the Western Indian population.
Echocardiographic Evaluation of Infants Born to Mothers with Gestational Diabetes Mellitus: A Cross-sectional Analytical Study
Authors: Sikdar Jahnabi , Das Partha Sarathi , Halder Dipanjan , Banerjee Joyashree , Mukhopadhyay Bulbul , Rana Ankita , Karan Suvomoy
Published: July 2024

Introduction: Gestational Diabetes Mellitus (GDM) is a chronic and progressive disease characterised by changes in the metabolism of carbohydrates, lipids, and proteins, leading to glucose intolerance. The foetal heart in GDM is affected throughout the gestational period, which may result in hyperplasia and hypertrophy of myocardial cells. Aim: To determine the cardiac function and structural changes in infants of gestational diabetic mothers using Dopplerechocardiographic data. Materials and Methods: A cross-sectional analytical study was conducted on 30 infants of mothers with GDM and 30 infants of non diabetic mothers at the Department of Physiology, R.G. Kar Medical College and Hospital, in collaboration with the Departments of Paediatric Medicine and Cardiology from January 2023 to August 2023. Neonatal screening echocardiography was performed by a cardiologist using a Philips Echocardiograph machine, Model: EPIQ 7C, Software Version: 4.0.2, with a linear convex probe of S8-3 MHz frequency to assess cardiac structure and function using 2D, M mode, and Conventional Doppler. The parameters studied included aortic root diameter (mm), left atrial diameter (mm), Interventricular Septal (IVS) in diastole (mm), left ventricular posterior wall thickness in diastole (mm), left ventricular internal diameter in diastole (mm), left ventricular internal diameter in end systole (mm), left ventricular fractional shortening (%), and left ventricular ejection fraction (%). Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) version-20.0 with an Independent Student’s t-test. Results: The mean gestational age for the cases was 38.50±2.57 weeks and 39.30±1.97 weeks for controls. The mean maternal age for cases was 25±4.37 years and for controls was 27±5.03 years. The left atrial diameter in cases (12.83±2.14 mm) was significantly smaller than that of the control (14.20±0.55 mm). The left ventricular posterior wall diameter in diastole was significantly increased in cases (4.53±0.50 mm) compared to controls (3.87±0.35 mm). Significant differences were observed in the interventricular septum in diastole {cases: 4.73±0.45 mm, control: 3.97±0.32 mm} and in the left ventricular internal diameter in end systole {cases: 12.30±1.84 mm, control: 13.83±1.02 mm} between cases and controls. Aortic root diameter was increased in 13.3% of cases. The percentage of left ventricular fractional shortening (cases: 35.47±3.74 %, Control: 38.53±2.43 %), Left Ventricular Ejection fraction (cases: 67.63±4.52 %, control: 72.17±4.89 %) were significantly decreased in cases compared to control. Conclusion: The present study demonstrated the development of ventricular hypertrophy and compromised myocardial contractility in infants of diabetic mothers.