bluuebunny/crossref_metadata_2025 huggingface dataset:
Central and Peripheral Analgesic and Anti-inflammatory effect of Plumbagin and Resveratrol: A Preclinical Study
Authors: Amale PN , Deshpande SA , Bora VR
Published: November 2023

Introduction: Millions of people are suffering from pain worldwide and current therapy provides its symptomatic relief with experience of some adverse effects. The plant nathoquinone-Plumbagin (PL) obtained from plumbago plants and a phytolexin-Resveratrol (RSV) from the skin of berries and grapes being a pleiotropic phytoconstituents have therapeutic potential to reduce experimentally induced pain and inflammation. We designed this preclinical study to evaluate the analgesic and anti-inflammatory effect of PL and RSV. Methods: Neuropathic pain (NP) was induced using chronic constriction injury (CCI) of sciatic nerve model followed by its assessment by thermal, mechanical and cold allodynia method. While, sub-plantar injection of 50µL 2.5% formalin induced nociception as well as inflammation. Evaluation of nociception and inflammation was done using nociceptive scoring and paw volume measurement using plethysmometer. NP and formalin induced animals were subjected for PL and RSV treatment following its evaluation. In vitro, and in-silico docking studies using Swiss-Dock web server were performed to correlate the anti-inflammatory and antioxidant potential. Results: The CCI and formalin induced pain and inflammation were confirmed by parametric assessment. In provoked rats, PL 2mg/kg and RSV 50mg/kg alone, while RSV (25mg/kg) and PL (1 mg/kg) in combination had synergistic analgesic and anti-inflammatory effects with agreeable in-silico interaction with the oxidative parameters. Discussion: PL and RSV through exhibit strong analgesic effect, PL-RSV combination was found to be safe with synergistic effects owing to their multi-target interactions. Future study may be designed to investigate the molecular and clinical robustness.
Revolutionized Drug Delivery by using Pulmonary Nanotechnology: A Review
Authors: Al-Halaseh Lidia Kamal , Al-Suhaimat Rawan , Al-Suhaimat Duaa , Al-Adaileh Teeb , Abu Hajleh Maha Nour , Al-Samydai Ali Mahmoud , Alkasasbeh Rehan , Nahar Al Soub Manal , Abu Dayyih Wael
Published: November 2023

Nanotechnology innovations have a positive impact on multidisciplinary health sectors, in particular, drug delivery. Variable nanocarriers were utilized in order to decrease systemic toxicity and enhance the delivery of drug particles to the targeted tissues. Systemic delivery of medicines through the pulmonary route of administration is still within limited boundaries. Delivering medicines loaded into nanoparticles through the pulmonary route for treating chronic and acute diseases such as diabetes, cancers, and even hormone therapy would be a novelty. Nanocarriers include lipid nanoparticles, liposomes, nano-emulsions, solid lipid nanoparticles, non-structured lipid carriers, and Multifarious inhaled Lipid-Based Nanocarriers. Promising results were obtained after delivering cytotoxic, hypoglycemic and anabolic agents. Although revolution in drug delivery and enhancements of drug efficacy are predicted, limitations and health hazards have to be taken into consideration. Physical stability, high loading capacity, good adhesion to the pulmonary wall are among the formulation supremacy. Also from a patient perspective, inhaled drugs carried by nanoparticles have minor side effects, faster response, more convenience to carry, and wide dosage intervals. Disadvantages range from expelling the minute particles which could result in delivering sub-effective doses to more serious health problems such as increased thrombosis activity.
Anal squamous cell carcinoma mimicking pyoderma gangrenosum in a patient with crohn’s disease
Authors:   Department of Gastroenterology, Saint George General Hospital of Chania, 73300, Crete, Greece., Mantaka Aikaterini
Published: November 2023

Anal neoplasia in Inflammatory Bowel Disease is rare and has been associated with HPV and perianal disease. We report a case of a large perianal ulcer in a patient with a non perianal Crohns disease that it was initially misdiagnosed and treated as pyoderma gangrenosum.
Osteogenesis Stimulator Devices Reduce Surgical Intervention, Opioid Utilization, and Overall Costs in Patients with Fracture Nonunions
Authors: Segina Daniel , Ryaby James
Published: November 2023

Background

Approximately 10% of fractures result in delayed union or nonunion. These cases result in pain and disability as well as increased utilization of healthcare resources such as pain medication, physical therapy, and subsequent surgery. Osteogenesis stimulator devices are a safe and low-cost, non-invasive option to aid healing in nonunion cases.

Objective

Study objectives aimed to evaluate real-world data of osteogenesis stimulator device usage in a variety of healthcare utilization endpoints including surgical intervention for nonunion, pain medication use, and overall healthcare costs. Data were stratified into three groups: the Stim Device group and the No Stim and Surgical control groups.

Methods

A retrospective analysis of a large claims-based database was conducted. The database was queried for adult patients having a diagnosis of nonunion, with evidence of a prior fracture in the previous 180 days (n = 11,010). The osteogenesis stimulator group (Stim Device group, n = 1,628) was defined as those patients having at least one claim for an osteogenesis stimulator in the period 90 to 180 days following fracture and up to 60 days following the nonunion diagnosis. The control group (No Stim group, n = 9,382) had a nonunion diagnosis with evidence of a fracture in the prior 180 days but did not receive a device. A total of 1,751 patients from the No Stim group were sub-grouped into surgical/operative controls (No Stim - Surgical group).

Results

Stim Device patients showed lower rates of surgical intervention for their bone nonunion compared to the No Stim patients (214/1,628, 13.1% vs. 1,751/9,382, 18.7%, p < 0.001). Stim Device patients had lower rates of opioid utilization post-index compared to No Stim patients (948/1,628, 58.2% vs. 6,359/9,382, 67.8%, p < 0.001). Overall healthcare costs were significantly reduced in the Stim Device group ($21,654) compared with No Stim ($29,101; p < 0.001) and Surgical ($35,914; p < 0.001) control groups.

Conclusion

The results show that bone growth stimulator devices have a positive individual and societal impact on treating patients with fracture nonunions.
Concrete Solarities
Authors: Simonetti Cristián
Published: November 2023

Concrete is a material that substantiates key contradictions of contemporary urban life. This anthropic rock, the most abundant in earth history, not only materializes modern narratives of progress but is currently a candidate to mark the onset of the Anthropocene. Moreover, contrary to how it has been traditionally portrayed by the industry, as a synthetic product of modern ingenuity, concrete results from a deep planetary relationship between the Earth and the Sun; the very same relationship that has made the existence of life in this planet, as we know it, possible, including humans. Attending to contemporary dystopias of Chile’s neoliberal experiment in Santiago, this chapter addresses the importance of the relationship between sunlight and concrete for understanding the human condition in the Anthropocene.
Affective Energy
Authors: Lennon Myles
Published: November 2023

This chapter draws from ethnographic research on solar energy activists in New York City to explore the unlikely preponderance of pastoral images of solar technology in a twenty-first century megacity. Why would activists focused on bringing renewable energy to urban communities aestheticize solar technology in rural landscapes bereft of humans? I respond to this line of inquiry by exploring the sun’s affective energy—its capacity to shape our imaginaries. I suggest that the sun’s shine on glossy solar panels enables us to imagine, feel, and pursue the technological natures of tomorrow—a vision that is often troublingly at-odds with the material realities of solar technologies.
Solar as Narrative Element
Authors: Williams Rhys
Published: November 2023

A poetics of weightlessness and light, of being sheer surface without depth or footprint, has come to dominate popular, corporate, and activist representations of solar technologies. This chapter claims that this widespread uptake is due to solar’s narrative and aesthetic affordance as an interrupting surface, acting to break the purchase of history upon the present, and excusing imaginaries of the future from the need to engage with the past. This claim will be explored through three examples in the final season of Detectorists, a quirky British comedy whose homely realism casts solar’s usual future-oriented aesthetics into relief.
The Ray and the Flame, or, What It Takes for the Sun to Shine
Authors: Ingold Tim
Published: November 2023

For the sun to shine, it cannot be a distant cosmic object, or an emitter of energetic rays. Shining does not connect me, by a long straight line of transmission, to the sun. It rather carries on, in real time, along an axis orthogonal to this line. This is the temporal axis of sentient awareness in the midst of a world forever on the burn. The sun’s shining, rather than spanning an interval of transmission, endures in the glare of combustion. In our experience, the sun is its light, not a source of light, and in its shining it erupts into a vision that, far from having closed itself off from a world ‘out there’, has opened itself to the boundless sky. Thus sunlight does not arrive from afar but ignites in the consciousness of the seer who sees with it, with eyes bathed in its luminosity. But the sun doesn’t only illuminate our world; it warms us too. So do the flames of the fire. Ray and flame rest on wholly different ontologies of the sun and its light. As an emitter of rays, the sun is transcendental, but as a beaming fireball, it is elemental.
Twilight
Authors: Boyer Dominic
Published: November 2023

Twilight is a one-scene play about the situations in which and the emotions with which we find ourselves in the climate emergency.
Frecuencia de la depresión y factores de riesgo en Embarazadas atendidas en Centros de Salud de Ibarra, 2021.
Authors: Benalcazar Vilatuña Katherin Estefanía , Alvear Reascos Rodrigo Roberto , Acosta Vinueza Lola Yesenia
Published: November 2023

sin embargo no se le ha dado la debida importancia, sabiendo que tiene  consecuencias tanto en la madre como en el feto. El objetivo de este artículo es determinar la frecuencia de la depresión  y los factores de riesgo en Embarazadas atendidas en Centros de Salud de Ibarra. Se realizó un estudio cuantitativo, observacional, y relacional de corte transversal, la muestra estuvo conformada por 120 mujeres embarazadas incluidas mediante un muestreo no probabilístico. Para la recolección de datos se empleó un cuestionario que contenía datos psicosociales, clínicos y sociodemográficos, la Escala de Depresión Perinatal de Edimburgo y la Escala de APGAR familiar. Los resultados y conclusiones obtenidos de la población estudiada tienen una alta prevalencia de depresión en el embarazo con un porcentaje del 35%, lo que representa una frecuencia de 42 casos positivos de 120 gestantes estudiadas. Dentro de los factores socioeconómicos estudiados como factores de riesgo para desarrollar depresión durante el embarazo encontramos a gestantes mayores de 35 años,  baja escolaridad, vivir en una población rural, el empleo inestable y desempleo. En cuanto a las características clínicas como factores de riesgo se presenta la multiparidad, antecedentes de aborto y complicaciones en el embarazo actual. En relación a los factores psicosociales se evidencia el consumo de sustancias psicoactivas, antecedentes de depresión, no tener apoyo social o familiar, disfunción familiar moderada y severa, violencia intrafamiliar.
brecha digital: Tecnologías de la Información y Comunicación (TIC), Necesidades Específicas de Apoyo Educativo (NEAE), Inclusión y Equidad
Authors: Huaca Guevara Grace Andrea
Published: November 2023

A partir de temas enfocados a la Educación en TIC; recursos digitales en contextos educativos; experiencias educativas de atención NEAE y NEE con TIC; metodologías innovadoras con TIC para la atención a la diversidad, inclusión y equidad, que con las TIC están desarrollando un papel diferenciador en la inclusión y revelan conciencia de la brecha digital y / o la brecha educativa con respecto a la diversidad de grupos sociales.
التقييم الكمي للتعرية المائية بحوض واد محاصر بالاعتماد على المعادلة العالمية لفقدان التربة: الأطلس الكبير−المغرب
Authors: السنبري عبد اللطيف , الهواري جواد , شطار الحسين
Published: November 2023

الملخص

تشكل التعرية المائية أحد التحديات الطبيعية التي يصعب معالجتها على المدى القصير؛ فقد أكدت العديد من الدراسات التي قام بها عدد من الباحثين المغاربة حول التعرية أن الوسط الطبيعي في تدهور مستمر؛ مما يهدد مستقبل التوازن البيئي. ويهدف هذا العمل إلى تقدير كمية الأتربة المفقودة بحوض واد محاصر بالأطلس الكبير الأوسط، من خلال توظيف نظم المعلومات الجغرافية، لنمذجة مختلف عوامل التعرية اعتماداً على المعادلة العالمية لفقدان التربة (USLE). ويمتد حوض واد محاصر على مساحة تقدر ب 214 كم2. ويتميز بوجود فوارق ارتفاعية وانحدارات مهمة، كما يتسم مناخه بشدة التساقطات وشبكة مائية تعرف بكثافتها، بالإضافة إلى صخور متنوعة المقاومة. والغطاء النباتي هو الآخر يتميز بطابع الانفتاح. بجانب ذلك نجد التدخلات السلبية للإنسان التي تساهم بشكل كبير في تدهور الوسط نتيجة استعمالاته المختلفة للمجال الطبيعي. لقد أظهرت نتائج تطبيق المعادلة العالمية للتربة أن الحوض يعرف فقدان التربة بشكل مهم، وبلغت أعلى النسب بالمنطقة العليا من الحوض، حيث سجلت أكثر من 20 طنّاً/هـ/السنة، كما سجلت أخفض القيم بسافلة الحوض أقل من 5 طن/هـ/السنة. هذا الاختلاف ناتج عن استعمالات التربة وطبيعة الانحدار داخل الحوض، بالإضافة إلى طبيعة الصخور. من خلال هذه النتائج، نأمل في أن يقدم هذا العمل الأفكار الأولى حول انجراف التربة في مناطق الأطلس الكبير. لذلك، هناك حاجة ملحة لبلورة إستراتيجيات الحفاظ على التربة في المناطق الزراعية؛ للحد من التعرية.
Efeito do pinçamento tardio do cordão umbilical nos níveis séricos de ferritina de crianças de 0, 3 e 6 meses de vida
Authors: Steffen Elizandra Leal , Silva José Edson Paz da , Weinmann Ângela Regina Maciel , Beltrame Paulo Afonso
Published: November 2023

Este estudo analisou o efeito do pinçamento tardio do cordão umbilical nos níveis de ferritina sérica de crianças de 0, 3 e 6 meses, que foi realizado no Centro Obstétrico do Hospital Universitário de Santa Maria-RS, Brasil, de maio de 2008 a abril de 2009. Foram analisados 101 recém-nascidos a termo, divididos em dois grupos: pinçamento precoce – de 0 segundo a 1 minuto após o nascimento (n = 41) e pinçamento tardio – de 1 a 3 minutos pós-nascimento (n = 60). Foram coletadas amostras de sangue venoso dos bebês, e a dosagem da ferritina sérica foi realizada no primeiro dia de vida, no terceiro e no sexto meses. Os resultados foram analisados pelo programa Statsoft Statistica v. 7.0.61.0EN. Para análise estatística foram utilizados teste Qui-Quadrado, teste de U Mann Whitney e teste de Correlação de Spearman. Os valores médios da ferritina no terceiro e no sexto meses mostraram-se superiores nas amostras de crianças do grupo de pinçamento tardio (111,82 ng/mL e 33,19 ng/mL, respectivamente) em relação às amostras do grupo de pinçamento precoce (97,79 ng/mL e 24,81 ng/mL, respectivamente). Estes dados fundamentam a alternativa de intervenção sustentável, de baixo custo e segura para integrar programas que visem à redução da deficiência de ferro em crianças, principalmente em países em desenvolvimento.
Desempenho da metodologia de revisão rápida de 100% em esfregaços citopatológicos do colo do útero com e sem informações clínicas
Authors: Manrique Edna Joana Cláudio , Souza Nadja Lindany Alves , Tavares Suelene Brito do Nascimento , Zeferino Luiz Carlos , Amaral Rita Goreti
Published: November 2023

Neste estudo foi avaliada a metodologia de revisão rápida de 100% em esfregaços com e sem informações de critérios de risco clínicos utilizando-se o tempo médio de um e dois minutos. Um total de 5.395 esfregaços foi analisado, dos quais 274 foram classificados como alterados e 5.121 como negativos após análise de rotina. Das amostras negativas, 958 continham informações de critérios de risco clínicos, as quais foram submetidas a revisão rápida, que identificou 10 (1,04%) como alteradas quando foi utilizado o tempo de um minuto e 9 (0,93 %) com o tempo de dois minutos. Dos 4.163 esfregaços negativos sem informações de critérios de risco clínicos, após revisão rápida utilizando tempo de um e dois minutos, 35 (0,84%) foram identificados como alterados em ambos os tempos. Em esfregaços com informações de critérios de risco clínicos, a metodologia de revisão rápida apresentou sensibilidade de 83% e 75%, respectivamente para o tempo de um minuto e dois minutos. Não houve diferença significativa na detecção de resultados falso-negativos em esfregaços com e sem informação de critérios de risco clínicos. Observou-se também que não houve diferença no desempenho da revisão rápida na detecção de resultados falso-negativos, utilizando-se os tempos de um e dois minutos.
Leveduras isoladas de uvas Vitis vinifera L. cultivadas na região equatorial brasileira
Authors: Assis Mariana Oliveira , Mamede Maria Eugênia de Oliveira , Guimarães Alaíse Gil , Santos Luize Sales , Rosa Carlos Augusto
Published: November 2023

O Vale do Submédio São Francisco, localizado nos estados da Bahia e Pernambuco, é uma das regiões mais promissoras na produção de vinho no Brasil. É ainda desconhecida a possibilidade dessa região em produzir vinhos por fermentação espontânea e gerar produto com características típicas regionais. Neste estudo foram isoladas e identificadas as leveduras da superfície de uvas Vitis vinifera L. frescas, cultivadas na região do Vale do Submédio São Francisco, Brasil. Os isolados foram identificados pelas características morfofisiológicas, habilidade de crescimento em meio de cultura ágar L-lisina e identificação bioquímica, baseando-se em testes fisiológicos (habilidade de fermentação da glicose, assimilação de fontes de carbono e nitrogênio, osmotolerância e termotolerância). Sessenta isolados de leveduras foram obtidos no meio ágar extrato de malte-extrato de levedura (YM); e todos foram pertencentes ao grupo não-Saccharomyces. Por meio de testes fisiológicos, 20 dos 60 isolados não foram agrupados em nenhum gênero. 40 dessas leveduras foram sugestivamente identificadas como pertencentes ao gênero Hanseniaspora spp. Dessas 40 amostras, 17 receberam sugestiva identificação como pertencentes à espécie Hanseniaspora guilliermondi. Em conclusão, a microbiota da casca das uvas cultivadas nessa região é predominada por leveduras não Saccharomyces, especificamente Hanseniaspora spp.
Avaliação da técnica de reação de polimerase em cadeia (PCR) para identificação de Mycobacterium bovis em microcolônias isoladas em camada delgada de ágar Middlebrook 7H11 modificado
Authors: Rosário Tatiana Reis do , Dib Cristina Corsi , Roxo Eliana , Pinheiro Sônia Regina , Vasconcellos Silvio Arruda , Benites Nilson Roberti
Published: November 2023

A associação da técnica de cultivo em camada delgada no meio de ágar Middlebrook 7H11 modificado com a Reação de Polimerase em Cadeia (PCR) possibilitou a identificação precoce de Mycobacterium bovis em colônias macroscópicas entre o 12º e o 25º dia de crescimento. Com o objetivo de diminuir o tempo necessário para efetuar a identificação de Mycobacterium bovis, avaliou-se o uso combinado dessas duas técnicas, em microcolônias de micobactérias, no oitavo dia pós-semeadura. Até o último dia de observação, todas as amostras com positividade no ensaio da PCR já apresentavam crescimento microscópico, possibilitando-se a realização de diagnóstico precoce da tuberculose bovina mesmo sem aparente crescimento macroscópico das colônias.
Precision medicine in immunotherapy and lung cancer
Authors: Sánchez Céspedes Montserrat
Published: November 2023

The inclusion into cancer clinical settings of the so-called immune-checkpoint inhibitors (ICIs), such as those targeting the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) and its ligand (PD-L1), has represented a breakthrough in cancer treatment, especially in non-small cell lung cancer (NSCLC), the most common type of lung cancer. Despite becoming the standard of care in some cancers, either alone or in combination with chemotherapy, a proportion of patients do not respond while others progress during treatment. Therefore, there is a clinical need to identify accurate predictive biomarkers and to develop novel therapeutic strategies based on ICIs. The current marker used to predict response to ICI treatments are the levels of PD-L1, but this is a quite inaccurate biomarker. In this review it will be described what is currently known about the dynamic interaction between the cancer cell and the immune system during carcinogenesis, with a particular focus on the description of the functions and alterations that preclude the host immunoresponse in cancer. We emphasize the deleterious gene alterations in components of the major histocompatibility complex and of the response to IFNγ. The role of other gene alterations, such as those of common oncogenes and tumor suppressors, and of the epigenetic alterations will also be discussed, in detail. Finally, we discuss the potential use of the tumor’s genetic profile to predict response to ICIs.
Trichomonas vaginalis: diagnosis of a forgotten sexually transmitted infection
Authors: Méndez Izquierdo Judit Ester , Fonseca Berzal Cristina , Ibáñez Escribano Alexandra
Published: November 2023

Trichomonas vaginalis is the protozoan parasite causative of one of the curable sexually transmitted infections that shows the highest annual incidence worldwide. However, the diagnostic methods most frequently used, are not sensitive enough and therefore, a large percentage of cases are not detected, especially in asymptomatic people. These traditional tests are not fast enough, and most of them are not suitable for carrying out diagnosis in men, with the consequent aggravation of the situation. In the last decades, new diagnostic techniques for trichomoniasis have been developed, which show much more acceptable sensitivity and specificity values, making it possible to reduce the time to diagnosis. Accordingly, their implementation could lead to a result in a few hours and thus, facilitate the start of treatment in those cases in which it is needed. In this framework, a bibliographic review of the most relevant techniques is carried out in the present work, including tests that are available for diagnosis in men, as well as for the detection of co-infections, highlighting their usefulness and both the advantages and disadvantages of each one.
Active cannabinoid nanocarriers for the treatment of atherosclerosis
Authors: Martín-Navarro Lucía , Martín-Banderas Lucía , Herrera María Dolores
Published: November 2023

In order to selectively deliver cannabinoid drugs (CB2 agonists) to the atherosclerotic plaque, biocompatible and biodegradable nanoparticles have been obtained. For this purpose, the PEGylated nanoparticles have been functionalized with a peptide capable of selectively binding to endothelial adhesion proteins overexpressed in the atherosclerotic plaque (vascular cell adhesion molecules 1, VCAM-1). The particles have been characterized physicochemically, in vitro in cell cultures and in vivo in an animal model of atherosclerosis (apolipoprotein E-deficient ApoE-/- mice), demonstrating optimal spatiotemporal control of cannabinoid release and superior pharmacological response. Given that CB2 agonist drugs present high lipophilicity and low availability, the introduction of selective nanosystems for the vehiculation of these antiatherogenic drugs would improve their bioavailability and efficacy.
The work presented shows part of the results obtained from a previous project. These results have supported us for the award of a new funding grant to address a more advanced strategy involving the introduction of diagnostic elements and a phytocannabinoid.
Novel Drugs Recently Authorized by EMA and FDA (Q2, 2023)
Authors: Cuéllar Rodríguez Santiago
Published: November 2023

EMA (EUROPEAN MEDICINES AGENCY):
(A) TRACTO ALIMENTARIO Y METABOLISMO: Cipaglucosidasa Alfa (Pombiliti®): enfermedad de Pompe. Pegunigalsidasa Alfa (Elfabrio®): enfermedad de Fabry. Velmanasa Alfa (Lamzede®): alfa manosidosis. (B) SANGRE Y SISTEMA HEMATOPOYÉTICO: Vadadustat (Vafseo®): anemia por insuficiencia renal. (D) DERMATOLOGÍA: Ruxolitinib (Opzelura®): vitíligo. (J) ANTIINFECCIOSOS SISTÉMICOS: Vacuna COVID-19 recombinante (Bimervax®): COVID-19. Vacuna Virus Respiratorio Sincitial (Arexvy®): Virus respiratorio sincitial. (L) AGENTES ANTINEOPLÁSICOS E INMUNOMODULADORES: Ivosidenib (Tibsovo®): leucemia mieloide aguda. Mirikizumab (Omvoh®): Colitis ulcerosa.FDA (U.S. FOOD & DRUG ADMINISTRATION):
(A) TRACTO ALIMENTARIO Y METABOLISMO: Esporas de microbiota fecal viva (Vowst®): recurrencia de infección por Clostridioides difficile . (B) SANGRE Y SISTEMA HEMATOPOYÉTICO: Efanesostocog alfa (Altuviiio®): hemofilia. Omidubicel (Omisirge®): trasplante de sangre de cordón umbilical. (D) DERMATOLOGÍA: Beremagene Geperpavec (Vyjuzek®): epidermolisis ampollosa. (G) SISTEMA GENITOURINARIO Y HORMONAS SEXUALES: Fezolinetant (Veozah®): sofocos asociados a menopausia. (J) ANTIINFECCIOSOS SISTÉMICOS: Rezafungina (Rezzayo®): candidiasis invasiva. Durlobactam/Sulbactam (Xacduro®): neumonía por Acinetobacter. (L) AGENTES ANTINEOPLÁSICOS E INMUNOMODULADORES: Ratifanlimab (Zynyz®): carcinoma de células de Merkel. Leniolisib (Joenja®): síndrome de PI3K-delta activado. Epcoritamab (Epkinly®): linfoma de células B. Glofitamab (Columvi®): linfoma de células B. (N) SISTEMA NERVIOSO: Tofersen (Qalsody®): esclerosis lateral amiotrófica. (S) ÓRGANOS SENSORIALES: Perfluorohexiloctano (Miebo®): ojo seco. (V) VARIOS: Flotufolastat F-18 (Posluma®): diagnóstico por imagen (PET).
HUBUNGAN DUKUNGAN SOSIAL DENGAN TINGKAT STRES PERAWAT DI RUMAH SAKIT SANTA ELISABETH MEDAN TAHUN 2022
Authors: Tampubolon Lindawati F. , Agustaria Ginting  , Sigalingging Vina Yolanda S. , Simanjuntak Reza Novita Yanti
Published: November 2023

Stres merupakan kondisi seseorang yang tidak mampu mengatasi masalah yang disebabkan oleh adanya emosi berlebihan dan tuntutan waktu yang berdampak pada kehidupan pribadi dan sosial di lingkungan. Dukungan sosial salah satu dorongan baik dari keluarga maupun teman sejawat berupa interaksi emosional, kognitif dan perilaku dalam membantu mengatasi stres di lingkungan kerja. Penelitian ini bertujuan menganalisis hubungan dukungan sosial dengan tingkat stres perawat di Rumah Sakit Santa Elisabeth Medan tahun 2022. Metode penelitian menggunakan rancangan korelasi dengan desain cross sectional. Populasi penelitian sebanyak 139 orang dengan jumlah sampel sebanyak 57 orang. Adapun teknik pengambilan sampel menggunakan proportional random sampling. Pengumpulan data dikumpulkan secara langsung dengan menggunakan kuesioner. Hasil penelitian didapatkan rerata dukungan sosial 37,60 dengan standar deviasi 5,250 dengan nilai CI 95% = 36,20-38,99, sedangkan rerata tingkat stres 58,79 dengan standar deviasi 13,089 dimana nilai CI 95% = 55,32-62,26. Hasil uji pearson product moment ditemukan nilai p-value = 0,004 (α <0,05) dimana nilai r = -0,380, artinya ada korelasi dukungan sosial dengan tingkat stres perawat. Korelasi sedang berpola negatif menunjukkan bahwa semakin rendah dukungan sosial semakin tinggi tingkat stres perawat
HUBUNGAN SPIRITUALITAS DENGAN PSYCHOLOGICAL WELL-BEING PADA SISWA SMP SWASTA ASSISI MEDAN TAHUN 2022
Authors: Derang Imelda , Lilis Novitarum  , Primerya Cindia
Published: November 2023

Psychological well-being merupakan kemampuan seseorang untuk menerima kelebihan dan kekurangan dalam dirinya agar menjadi pribadi yang mandiri, bertanggung jawab serta berfikir positif baik untuk diri sendiri dan orang lain. Oleh karena itu sangatlah diperlukan spiritualitas yang baik dalam diri seseorang agar dapat merasakan Tuhan dalam realita hdup untuk mencapai tujuan yang lebih baik. Penelitian ini bertujuan untuk mengetahui hubungan spiritualitas dengan psychological well-being  pada siswa SMP Swasta Assisi Medan tahun 2022. Jenis penelitian yang digunakan dalam penelitian ini adalah analitik korelasi. Populasi pada penelitian ini siswa SMP Swasta Assisi Medan sebanyak 420 orang. Pengambilan sampel menggunakan teknik Purposive Sampling responden sebanyak 78 orang di temukan bahwa responden yang memiliki spiritualitas yang tinggi sebanyak 50 orang (64,1%) dan psychological well-being sedang sebanyak 57 orang (73,1%). Hasil uji statistik pearson product moment  diperoleh r = (.542) dan p (value) = 0,000 (p<0,05) sehingga dapat disimpulkan bahwa terdapat hubungan yang signifikan antara spiritualitas dengan psychological well-being siswa. Hubungan yang kuat artinya semakin tinggi spiritualitas maka akan semakin tinggi psychological well-being siswa SMP. Siswa yang memiliki spiritualitas yang tinggi akan berusaha meningkatkan kesejahteraan psikologikalnya dengan cara dapat menerima siapa dirinya, menjalani kehidupan secara mandiri, memiliki tujuan hidup, dan membangun hubungan positif dengan orang lain.
INFLUENCE OF BRAND IMAGE ON THE WORD OF MOUTH WHICH IMPLICATES TO BRAND EQUITY SPORT EVENT SRIWIJAYA RANAU GRAN FONDO 2022
Authors: Kurniawan Ahmad , Rini Andari  , Caria Ningsih
Published: November 2023

There is a change in consumer behavior from the pandemic to the pandemic transition that affects the brand equity sport event Sriwijaya Ranau Gran Fondo 2022, thus making researchers analyze the extent to which the relationship between brand image factors includes brand congruence, brand trust, brand commitment, to word of mouth which has implications for brand equity sport event can affect the behavior of consumers or participants. Using a quantitative research method with a descriptive and survey research design using a sample of 353 respondents from the participants present, then analyzed using quantitative descriptive statistical analysis and structural equation model (SEM) analysis. The results showed that there was a significant effect of brand congruence on brand trust, there was a positive relationship between brand congruence and brand commitment, a positive direct effect of brand trust on brand commitment, there was no significant relationship between brand trust and word of mouth, there was an influence between brand commitment on word of mouth, and there is a significant strong relationship between word of mouth and brand equity. Thus it has implications for sport event organizers to continue to increase the satisfaction and comfort of consumers or attendees, as well as correcting deficiencies in values that do not meet the needs of consumers or participants in order to develop a very good sports event brand image.
Chemical composition and antimicrobial activity of Cordia globosa (JACQ.) essential oil against Staphylococcus aureus
Authors: Catunda Jr Francisco Eduardo Aragão , De Sá Ponte Junior Eriberto , Ferreira de Araújo Thiago , Thais Arruda Cavalcante Theodora
Published: November 2023

Cordia globosa (Jacq.), conhecida como "maria preta" na região Nordeste do Brasil, é uma planta de ampla utilização no tratamento de doenças gastrointestinais. Este trabalho teve como objetivo obter o perfil químico do óleo essencial da parte aérea de C. globosa, atividade antimicrobiana e antibiofilme contra Staphylococcus aureus. Nas análises de GC/MS foram detectados 47 compostos, dos quais monoterpenos 17,74%, monoterpenos oxigenados 6,84%, sesquiterpenos 40,50%, sesquiterpenos oxigenados 29,87%. Óxido de cariofileno 13,04%, β-Elemeno 12,30% e E-cariofileno 10,13%. Nos resultados, a CIM e o CBM foram de 1 mg/mL e 8 mg/mL, respectivamente. A ação antibiofilme foi confirmada para reduzir a biomassa do biofilme de S. aureus em até 97% entre concentrações de 2mg/mL e 4mg/mL. O óleo essencial de C. globosa demonstrou ser um antibiótico promissor contra S. aureus.
A fitoterapia como tratamento alternativo da dermatite atópica
Authors: Araújo Eliza Mayara Lopes de , Lima Salatiel Henrique Pereira de , De Santana Souza Ednaldo , Lima Liliane Bezerra de
Published: November 2023

A Dermatite Atópica (DA) é uma condição cutânea crônica com sintomas inflamatórios, multifatoriais e genéticos, afetando 6,3% da população brasileira. O tratamento convencional inclui hidratação da pele e corticosteroides, aliado a terapias adjuvantes, como a fitoterapia, são exploradas para melhorar o manejo dessa condição. Nesta revisão de literatura, os objetivos incluem analisar o potencial da fitoterapia no tratamento complementar da dermatite atópica. A pesquisa envolveu a busca em diversas fontes eletrônicas, na qual logo em seguida foi feita a seleção criteriosa de estudos baseado em critérios como atualidade, conteúdo apropriado e relevância ao tema pesquisado para cumprir os objetivos. Os dados mostraram uma abordagem multifacetadas, incluindo educação sobre a doença, cuidados com a pele, uso de corticosteroides tópicos e, em complemento, fitoterapia com substâncias como camomila, aloe vera, óleo de coco, entre outros que podem ajudar a aliviar os sintomas e promover a cicatrização da pele. No entanto, a eficácia e segurança dessas substâncias variam de pessoa para pessoa, e o tratamento deve ser personalizado de acordo com a gravidade das lesões e a frequência das crises inflamatórias.
Ethical Considerations for using Chatbots in Research
Authors: Khan Rehan Ahmed
Published: November 2023

The use of artificial intelligence (AI) chatbots for generating original written content, including articles, thesis, and assignments, has experienced a significant surge(Khan, R. A., Jawaid, M., Khan, A. R., and Sajjad, M 2023). Researchers now have the ability to command chatbots, such as ChatGPT, to draft complete research papers, including systematic reviews, case reports, and original research. However, this widespread adoption has raised several ethical concerns regarding the appropriate usage of chatbots in academic writing (Fatani., 2023). This editorial explores the ethical implications associated with utilizing chatbots in research and highlights the need for clear guidelines and distinctions between plagiarism and legitimate support from AI chatbots.
Disseminating the evidence and outputs generated by your programme
Authors: Haßler Björn , Friese Laila , Mansour Hassan
Published: November 2023

An output of the EdTech Hub, https://edtechhub.org/
Estrategias de gestión del conocimiento para el fortalecimiento de la competencia en lengua extranjera de docentes universitarios
Authors: Novikova Olga , Romero Díaz Carmen Helena
Published: November 2023

este libro permite responder a la necesidad de proveer mecanismos que contribuyan a la consolidación de la competencia en lengua extranjera de los docentes, por medio de la gestión del conocimiento, considerando los requerimientos para la acreditación en alta calidad de las IES públicas de la nación. En cuanto a las motivaciones que han promovido el desarrollo de este libro, se encuentra el deseo permanente de una mejora continua de la actividad docente universitaria, en los términos de una calidad educativa que promueve la figura de profesores bilingües.
Introducción del cigarrillo y del tabaco elaborados en el departamento de Antioquia: desafíos y recomendaciones
Authors: Gómez Zapata Yuliana , Zapata Montoya Maria Gardenia , Zapata Álvarez Luisa Fernanda , Usma Zuleta Leidy Jhojana , Ceballos Urrego Leonardo , Giraldo González Laura Catalina , Jaime Laínez Gabriel
Published: November 2023

este producto responde a los ejes misionales del Tecnológico de Antioquia - Institución Universitaria, los cuales se enmarcan desde los componentes de docencia, extensión e investigación. Con ellos se pretende impactar la realidad social de las comunidades, a partir del relacionamiento entre sujetos, de estos con el medio y sus manifestaciones culturales, permitiendo el análisis y la explicación.Es en este sentido que el Grupo de Investigación Observatorio Público, adscrito a la Facultad de Ciencias Administrativas y Económicas, incentiva a prácticas investigativas alrededor de fenómenos presentados en los territorios, los cuales, a partir de lo académico-investigativo, son objeto de estudio y pretenden mejorar las captación de recursos; además, en los que se busca conocer las prácticas sociales para fomentar la transformación de la cultura de la legalidad y fortalecer las rentas que hacen parte de la inversión social del departamento de Antioquia.
A Review of Hybrid Technology Applications and Development Trends
Authors: Li Jiayi
Published: November 2023

Currently, fossil fuel combustion and carbon emissions are triggering an increasingly serious greenhouse effect, which, coupled with the energy crisis, requires the transformation and upgrading of power modes for vehicles, transportation and engineering instruments. Due to the limitations of batteries in terms of energy density and range, pure electric drive cannot well meet the daily driving needs. The central idea of hybrid power is to make the internal combustion engine (ICE) and electric motor (EM) work together to improve energy utilization, energy saving and at the same time solving the problem of short range of electric vehicles. Vehicles and instruments utilizing hybrid powertrains have low emissions, low fuel consumption levels, high fuel economy, and energy recovery at the same time. This paper provides an overview of the structure and energy forms of hybrid technology and their applications, design simulations done by previous authors, optimization strategies, and summarizes the future trends of hybrid technology.
Analysis of Heat Dissipation of Lithium Battery Pack Based on Eddy Current Tube
Authors: Li Shuangliang , Jing Tao , Li Changpeng , Han Xue , Hua Ye , Teng Zhang
Published: November 2023

In this study, numerical heat dissipation simulation is carried out using vortex tube heat dissipation technique for the heat dissipation problem of lithium batteries. First of all, the type of lithium battery, thermal runaway phenomenon, thermal runaway temperature range, and then the lithium battery group cooling methods and advantages and disadvantages of the exposition; followed by the working principle of eddy current tube, the application of the way, as well as the advantages and disadvantages of the exposition. Combined with the vortex tube's own structural characteristics, numerical simulation is used to apply the vortex tube cooling to lithium battery heat dissipation. This study provides new ideas and methods for the development of lithium battery heat dissipation technology, and has important reference value for solving the heat dissipation problems of lithium battery in practical applications.
The New Mission of Abandoned Architectural Heritage
Authors: Cheng Zixuan , Yan Yuhan
Published: November 2023

The construction of pit cave dwellings is a longstanding custom in China. However, as living standards have increased, this distinctive style of building is being gradually forgotten. Sanmenxia, Henan Province is known for its unique clay, which has contributed to the advancement of construction and architectural design. The region's unique climate, which is warm in the winter and cool in the summer, has also made people more nostalgic, which has led to a boom in the tourism industry. It's urgent to figure out how to revitalize and change the historic structures that will soon decay and vanish into something new in order to stay relevant.This essay explores the distinctive architectural style of China's pit cave dwellings, capturing its essence and adapting it to modern demands. It also serves to highlight the disappearing ancient architectural and cultural form while revitalizing the abandoned kiln and bringing it back to life. Enhancing the recreational area for the locals and drawing attention to the region's distinctive culture, the abandoned kiln will be transformed into a tourist destination with cultural activities.
Exploration of Online and Offline Mixed Teaching Model for Data Structure Courses Based on the Ideological and Political Education
Authors: Zhang Hanfei
Published: November 2023

The traditional offline teaching in the data structure courses had problems such as programming training, concept and application separation. The paper analyzed the current situation of mixed online and offline teaching research in the data structure courses, explored the implementation path of ideological and political education, used diversified teaching methods and multi-dimensional evaluation systems, and strengthened the organic combination of ideological and political education with course content. A online and offline mixed teaching model based on the ideological and political perspective of the curriculum has been proposed. This provided valuable reference for the ideological and political education courses.
Study on Performance Characteristics and Influencing Factors of Four-outlet Centrifugal Pump
Authors: Hu Kun , Yang Kaifa , Zhang Zizhao
Published: November 2023

In order to study the influence of different geometric parameters and performance parameters on the external characteristics and outlet head uniformity of a single-stage multi-outlet centrifugal pump, a certain single-stage four-outlet water pump was chosen as the research object. Under the premise of keeping all parameters except the target parameter constant, the number of impeller blades, outlet width, and mass flow rate at the outlet were studied separately to explore the variation trends of the average pressure fluctuation rate and average head when the number of blades changed from 5 to 8. The study was combined with numerical simulation calculations. The research showed that as the number of blades increased, the head of the centrifugal pump gradually increased. When the number of blades was between 5 and 7, the increase in head was more significant, with an increase of 0.61m. When the number of blades increased to 8, the increase in head became relatively gentle, with only a 0.17m increase. When the impeller blades increased from 5 to 6, the pressure fluctuation rate at the outlet decreased by 0.4%. When the number of blades increased to 7, the pressure fluctuation rate decreased by 1.85%. When the number of blades increased to 8, the pressure fluctuation rate decreased by 0.8%. When the outlet width changed from 5.2mm to 6.7mm, the head increased by 0.4m, with an increase of 6.4%, and the pressure fluctuation rate at the outlet decreased by 2.9%. As the outlet flow rate increased from 15L/min to 30L/min, the head of the centrifugal pump decreased by 1m, and the pressure fluctuation rate at the outlet increased by 3.4%, indicating an increasing difference in head among the outlets.
Advancing Cancer Document Classification with R andom Forest
Authors: Che Chang , Hu Hao , Zhao Xinyu , Li Shulin , Lin Qunwei
Published: November 2023

In this study, we address the challenging task of biomedical text document classification of Cancer Doc Classification, specifically focusing on lengthy research papers related to cancer. Unlike previous research that often deals with shorter abstracts and concise summaries, we curated a unique dataset comprising documents with more extensive content, each exceeding 6 pages in length. To tackle this classification challenge, we employed the Random Forest Tree method. Random Forest is a powerful ensemble learning technique that combines multiple decision trees to enhance classification accuracy and robustness. It has been widely adopted in the field of machine learning and data science for its effectiveness in handling complex classification tasks.
A Comprehensive Study on Early Alzheimer’s Disease Detection through Advanced Machine Learning Techniques on MRI Data
Authors: Lin Qunwei , Che Chang , Hu Hao , Zhao Xinyu , Li Shulin
Published: November 2023

Alzheimer’s Disease (AD) is a neurodegenerative condition affecting predominantly elderly individuals, repre- senting the most common cause of dementia. Early clinical manifestations of AD include selective memory impairment, and while certain symptomatic improvements can be achieved through treatment, there is currently no cure. Magnetic Resonance Imaging (MRI) is utilized for brain imaging to assess suspected AD patients, providing results that include local and global brain atrophy. Some studies suggest that MRI features can predict the rate of AD decline and guide future treatments. However, to reach this stage, clinicians and researchers must employ machine learning techniques for accurate prediction of the progression from mild cognitive impairment to dementia. We propose the development of a reliable model to assist clinicians in achieving this and predicting early-stage Alzheimer’s Disease.
Family Language Ideology in English and Academic Performance of Junior High School Students in Chongzuo City of Guangxi Border Areas
Authors: Yi Chunyan
Published: November 2023

The study aimed to explore the family language ideology in English and academic achievement among junior high school students. By adopting a quantitative approach, data were collected from students. The findings indicated that students had a negative perception towards English as a destructive language, held a favorable view of English as a pluralistic language, and recognized its importance in embracing diversity but also perceiving it as relatively irrelevant to their local community. The results also revealed no significant relationship between students' perception of family language ideology and their English grades. The study highlighted the need for comprehensive language programs with differentiated instruction and interventions to enhance students' language proficiency. Recommendations include promoting multilingualism, enhancing cultural sensitivity and curriculum, involving community, implementing long-term research to delve into qualitative studies to gain deeper insights into language attitudes and academic performance among students, and considering the socio-cultural context.
Research and Practice of Mixed Online and Offline Marine English Teaching Strategies for Social Students
Authors: Huang Xiang
Published: November 2023

As the main practitioners of maritime industry, social trainees are the main practitioners of China's maritime power strategy. Maritime English, as the official language of maritime practitioners, is an important means of efficient communication and exchange among maritime practitioners from all over the world. In the context of the post pandemic, online teaching methods have injected new vitality into continuing education, and blended online and offline teaching has become an important content of teaching reform. This article takes the online and offline blended teaching of maritime English for social students as the main entry point, and proposes teaching optimization practical strategies from various aspects such as course teaching theory foundation, teaching design, and integration of course ideological and political points. Practice has proven that this teaching strategy can stimulate students' learning enthusiasm and effectively improve learning effectiveness.
Prepositions “about” and “for” Error Analysis and Teaching Strategy
Authors: Chu Guanfeng
Published: November 2023

Based on the combination of descriptive bias corpus and inductive bias types, and supported by contrastive analysis theory, interlanguage theory and bias analysis theory, this paper uses contrastive analysis, literature analysis and statistics to investigate the bias of international students in the use of prepositions “for” and “about”.