bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbon nanotubes promote cell migration in hydrogels
Authors: Ravanbakhsh Hossein , Bao Guangyu , Mongeau Luc
Published: February 2020

Injectable hydrogels are increasingly used for in situ tissue regeneration and wound healing. Ideally, an injectable implant should promote the recruitment of cells from the surrounding native tissue and allow cells to migrate freely as they generate a new extracellular matrix network. Nanocomposite hydrogels such as carbon nanotube (CNT)-loaded hydrogels have been hypothesized to promote cell recruitment and cell migration relative to unloaded ones. To investigate this, CNT-glycol chitosan hydrogels were synthesized and studied. Chemoattractant-induced cell migration was studied using a modified Boyden Chamber experiment. Migrated cells were counted using flow cytometry. Cell adhesion was inferred from the morphology of the cells via an image segmentation method. Cell migration and recruitment results confirmed that small concentrations of CNT significantly increase cell migration in hydrogels, thereby accelerating tissue regeneration and wound healing in situations where there is insufficient migration in the unloaded matrix.
Light transport and vortex-supported wave-guiding in micro-structured optical fibres
Authors: Pryamikov Andrey , Alagashev Grigory , Falkovich Gregory , Turitsyn Sergei
Published: February 2020

In hydrodynamics, vortex generation upon the transition from smooth laminar flows to turbulence is generally accompanied by increased dissipation. However, vortices in the plane can provide transport barriers and decrease losses, as it happens in numerous geophysical, astrophysical flows and in tokamaks. Photon interactions with matter can affect light transport in ways resembling fluid dynamics. Here, we demonstrate significant impact of light vortex formation in micro-structured optical fibres on the energy dissipation. We show possibility of vortex formation in both solid core and hollow core fibres on the zero energy flow lines in the cladding. Through intensive numerical modelling using different independent approaches, we discovered a correlation between appearance of vortices and reduction of light leakage by three orders of magnitude, effectively improving wave guiding. This new effect potentially might have strong impact on numerous practical applications of micro-structured fibres. For instance, a strong light localization based on the same principle can also be achieved in the negative curvature hollow core fibres.
Cryptic species in the parasitic Amoebophrya species complex revealed by a polyphasic approach
Authors: Cai Ruibo , Kayal Ehsan , Alves-de-Souza Catharina , Bigeard Estelle , Corre Erwan , Jeanthon Christian , Marie Dominique , Porcel Betina M. , Siano Raffaele , Szymczak Jeremy , Wolf Matthias , Guillou Laure
Published: February 2020

As critical primary producers and recyclers of organic matter, the diversity of marine protists has been extensively explored by high-throughput barcode sequencing. However, classification of short metabarcoding sequences into traditional taxonomic units is not trivial, especially for lineages mainly known by their genetic fingerprints. This is the case for the widespread Amoebophrya ceratii species complex, parasites of their dinoflagellate congeners. We used genetic and phenotypic characters, applied to 119 Amoebophrya individuals sampled from the same geographic area, to construct practical guidelines for species delineation that could be applied in DNA/RNA based diversity analyses. Based on the internal transcribed spacer (ITS) regions, ITS2 compensatory base changes (CBC) and genome k-mer comparisons, we unambiguously defined eight cryptic species among closely related ribotypes that differed by less than 97% sequence identity in their SSU rDNA. We then followed the genetic signatures of these parasitic species during a three-year survey of Alexandrium minutum blooms. We showed that these cryptic Amoebophrya species co-occurred and shared the same ecological niche. We also observed a maximal ecological fitness for parasites having narrow to intermediate host ranges, reflecting a high cost for infecting a broader host range. This study suggests that a complete taxonomic revision of these parasitic dinoflagellates is long overdue to understand their diversity and ecological role in the marine plankton.
Author Correction: Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
Authors: Napso Tina , Hung Yin-Po , Davidge Sandra T. , Care Alison S. , Sferruzzi-Perri Amanda N.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publisher Correction: Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells
Authors: Vaněk Ondřej , Celadova Petra , Skořepa Ondřej , Bláha Jan , Kalousková Barbora , Dvorská Anna , Poláchová Edita , Pucholtová Helena , Kavan Daniel , Pompach Petr , Hofbauerová Kateřina , Kopecký Vladimír , Mesci Aruz , Voigt Sebastian , Carlyle James R.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Creep in Primary Consolidation with Rate of Loading Approach
Authors: Bi Gang , Ni Shuna , Wang Dong , Chen Yeqiang , Wei Jianfei , Gong Wenzong
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Whole rumen metagenome sequencing allows classifying and predicting feed efficiency and intake levels in cattle
Authors: Delgado Beatriz , Bach Alex , Guasch Isabel , González Carmen , Elcoso Guillermo , Pryce Jennie E. , Gonzalez-Recio Oscar
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publisher Correction: Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome
Authors: Weinberg Robert P. , Koledova Vera V. , Subramaniam Avinaash , Schneider Kirsten , Artamonova Anastasia , Sambanthamurthi Ravigadevi , Hayes K. C. , Sinskey Anthony J. , Rha ChoKyun
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Volume expansive pressure (VEP) driven non-trivial topological phase transition in LiMgBi
Authors: Sattigeri Raghottam M. , Pillai Sharad Babu , Jha Prafulla K. , Chakraborty Brahmananda
Published: February 2020

Half-Heusler compound LiMgBi exhibits pressure driven Topological Insulating (TI) nature with robust spin-locked dissipationless Fermion transport along the surface states.
Spontaneous liquid water dissociation on hybridised boron nitride and graphene atomic layers from ab initio molecular dynamics simulations
Authors: Grosjean Benoît , Robert Anton , Vuilleumier Rodolphe , Bocquet Marie-Laure
Published: February 2020

By means of ab initio simulations we unveil the high reactivity of boron nitride–graphene planar heterostructure immersed in liquid water: an interfacial water molecule is found to spontaneously chemisorb and deprotonate at one composite border.
Intramolecular hydrogen tunneling in 2-chloromalonaldehyde trapped in solid para-hydrogen
Authors: Gutiérrez-Quintanilla Alejandro , Chevalier Michèle , Platakyte Rasa , Ceponkus Justinas , Crépin Claudine
Published: February 2020

Trapping 2-chloromalonaldehyde in solid para-hydrogen is used for a powerful insight into the H-tunneling process at various vibrational levels.
Pulse radiolysis study on the reactivity of NO3˙ radical toward uranous(iv), hydrazinium nitrate and hydroxyl ammonium nitrate at room temperature and at 45 °C
Authors: Musat R. , Marignier J. L. , Le Naour C. , Denisov S. , Venault L. , Moisy Ph. , Mostafavi M.
Published: February 2020

Concentrated nitric acid solutions subjected to radiation produce radicals of extreme importance in the reprocessing of spent nuclear fuel.
Magnetic chains of Fe3 clusters in the {Fe3YO2} butterfly molecular compound
Authors: Rubín Javier , Badía-Romano Laura , Luis Fernando , Mereacre Valeriu , Prodius Denis , Arauzo Ana , Bartolomé Fernando , Bartolomé Juan
Published: February 2020

Supramolecular magnetic chains of Fe3 cluster in a molecular complex.
Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1
Authors: Gan Mailin , Shen Linyuan , Wang Shujie , Guo Zhixian , Zheng Ting , Tan Ya , Fan Yuan , Liu Lin , Chen Lei , Jiang Anan , Li Xuewei , Zhang Shunhua , Zhu Li
Published: February 2020

Genistein may regulate lipid metabolism in adipose tissue of obese mice by regulating the expression of miR-222 and its target genes, BTG2 and adipor1.
The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways
Authors: Yang Yi , Zhang Lihui
Published: February 2020

AD is a neurodegenerative disease that commonly occurs among older individuals. Caloric restriction and its mimetics have been shown to alleviate amyloid burden, tau pathology, and improve cognitive function of rodent models of AD by activating autophagy.
Understanding laccase/HBT-catalyzed grass delignification at the molecular level
Authors: Hilgers Roelant , van Erven Gijs , Boerkamp Vincent , Sulaeva Irina , Potthast Antje , Kabel Mirjam A. , Vincken Jean-Paul
Published: February 2020

An in-depth study on the pathways underlying wheat straw and corn stover delignification by a laccase/HBT system. New insights were obtained by comprehensive fractionation, purification and analysis.
Microfabricated electrochemical sensing devices
Authors: Sassa Fumihiro , Biswas Gokul Chandra , Suzuki Hiroaki
Published: February 2020

Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities.
Development and validation of a bioanalytical HPLC method for simultaneous estimation of cinnamaldehyde and cinnamic acid in rat plasma: application for pharmacokinetic studies
Authors: Shetty Varsha , Chellampillai Bothiraja , Kaul-Ghanekar Ruchika
Published: February 2020

A rapid, sensitive and accessible HPLC-UV method was developed and validated for simultaneous detection of CNAD and CA up to 1.0 ng ml−1 in plasma samples.
Unconventional DNA-relevant π-stacked hydrogen bonded arrays involving supramolecular guest benzoate dimers and cooperative anion–π/π–π/π–anion contacts in coordination compounds of Co(ii) and Zn(ii) phenanthroline: experimental and theoretical studies
Authors: Bhattacharyya Manjit K. , Saha Utpal , Dutta Debajit , Frontera Antonio , Verma Akalesh K. , Sharma Pranay , Das Amal
Published: February 2020

Antiproliferative evaluation and supramolecular assemblies of Co(ii) and Zn(ii) coordination compounds involving cooperative anion–π and unconventional DNA-relevant π-stacked hydrogen bonded arrays.
Efficient reduction of graphene oxide to graphene nanosheets using a silica-based ionic liquid: synthesis, characterization and catalytic properties of IMD-Si/FeCl4−@GNS
Authors: Khan Mohd Umar , Siddiqui Shaheen , Khan Waqas Ahmad , Siddiqui Zeba N.
Published: February 2020

Ionic liquid-modified graphene nanosheets (IMD-Si/FeCl4−@GNS) have been synthesized as efficient catalysts for the synthesis of (E)-selective thiosemicarbazones.
Original synthesis route of bulk binary superconducting graphite intercalation compounds with strontium, barium and ytterbium
Authors: Cahen S. , El-Hajj I. , Speyer L. , Berger P. , Medjahdi G. , Lagrange P. , Lamura G. , Hérold C.
Published: February 2020

The synthesis route in molten salts allows the bulk intercalation into graphite of elements hardly intercalated by themselves. XRD and ion beam analyses show for instance the possible synthesis of SrC6.
Seed-mediated growth of heterostructured Cu1.94S–MS (M = Zn, Cd, Mn) and alloyed CuNS2(N = In, Ga) nanocrystals for use in structure- and composition-dependent photocatalytic hydrogen evolution
Authors: Zhu Dongxu , Ye Haihang , Liu Zheming , Liu Jun , Fu Hao , Huang Yanbin , Teng Feng , Wang Zhijie , Tang Aiwei
Published: February 2020

A seed-mediated method was developed for the synthesis of Cu-based heterostructured and alloyed nanocrystals, and the heterostructured and alloyed CuGaS2nanocrystals showed enhanced photocatalytic activities toward hydrogen production by water splitting.
Polymer-functionalized polymer nanoparticles and their behaviour in suspensions
Authors: Wichaita Waraporn , Kim Young-Gon , Tangboriboonrat Pramuan , Thérien-Aubin Héloïse
Published: February 2020

In concentrated suspensions of polymer-functionalized nanoparticles, the softness of the core nanoparticles has a crucial effect on the mechanical behaviour of the resulting colloidal gels.
Facile and accelerated production of RuO2 monolayers via a dual-step intercalation process
Authors: Kim Se Yun , Shin Weon Ho , Jung Doh Won , Ko Dong-Su , Roh Jong Wook , Hwang Sungwoo , Lee Jongmin , Lee Kimoon , Park Hee Jung , Kwak Chan , Kim Sang-il , Jeong Hyung Mo , Lee Kyu Hyoung , Kim Hyun Sik
Published: February 2020

RuO2 monolayer nanosheets were prepared by a rapid and efficient dual step exfoliation process.
Efficient polymer dimerization method based on self-accelerating click reaction
Authors: Liu Xueping , Wu Ying , Zhang Minghui , Zhang Ke
Published: February 2020

A convenient and efficient method was developed to prepare topological polymers with a symmetric molecular structure by dimerizing azide terminated polymers based on the self-accelerating double strain-promoted azide–alkyne cycloaddition reaction.
Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors
Authors: AboulMagd Asmaa M. , Hassan Hossam M. , Sayed Ahmed M. , Abdelmohsen Usama Ramadan , Abdel-Rahman Hamdy M.
Published: February 2020

The E isomer of compound 5 exhibited a potent inhibitory effect against PIM kinase isoforms of IC50s 0.30–0.41 μM.
Highly selective colorimetric determination of catechol based on the aggregation-induced oxidase–mimic activity decrease of δ-MnO2
Authors: Xiao Pengyu , Liu Yang , Zong Wenjing , Wang Jin , Wu Minghuo , Zhan Jingjing , Yi Xianliang , Liu Lifen , Zhou Hao
Published: February 2020

A new determination mechanism for catechol: aggregation-induced oxidase-mimic activity decrease of δ-MnO2.
Dye-sensitized solar cells under ambient light powering machine learning: towards autonomous smart sensors for the internet of things
Authors: Michaels Hannes , Rinderle Michael , Freitag Richard , Benesperi Iacopo , Edvinsson Tomas , Socher Richard , Gagliardi Alessio , Freitag Marina
Published: February 2020

Indoor light harvesters enable machine learning on fully autonomous IoT devices at 2.72 × 1015 photons per inference.
Nickel mediated palladium free photocatalytic Suzuki-coupling reaction under visible light irradiation
Authors: Prajapati Pankaj Kumar , Saini Sandhya , Jain Suman L.
Published: February 2020

Suzuki coupling is an important, extensively investigated, and manifold approach for C–C bond construction in synthetic chemistry.
Bifunctional Au-templated RNA nanoparticles enable direct cell uptake detection and GRP75 knockdown in prostate cancer
Authors: Shah Sunil S. , Cultrara Christopher N. , Ramos Jorge A. , Samuni Uri , Zilberberg Jenny , Sabatino David
Published: February 2020

A new method for formulating Au-RNA nanoparticles has enabled direct cell uptake detection and RNAi activity in prostate cancer cells.
Application of ultrasonic sprayed zirconium oxide dielectric in zinc tin oxide-based thin film transistor
Authors: Oluwabi Abayomi T. , Katerski Atanas , Carlos Emanuel , Branquinho Rita , Mere Arvo , Krunks Malle , Fortunato Elvira , Pereira Luis , Oja Acik Ilona
Published: February 2020

A typical schematic for both spray pyrolysis set-up and ZrOx-based TFT device, and the corresponding electrical performance.
From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors
Authors: Arroyo-Currás Netzahualcoyotl , Dauphin-Ducharme Philippe , Scida Karen , Chávez Jorge L.
Published: February 2020

The ultimate goal of implantable electrochemical, aptamer-based (E-AB) sensors is to enable the continuous and precise monitoring of clinically and physiologically important targets in the body for prolonged periods.
Rational design and latest advances of polysaccharide-based hydrogels for wound healing
Authors: Hu Hao , Xu Fu-Jian
Published: February 2020

This review presented the crucial design considerations and current state of polysaccharide-based hydrogels as wound dressings. The commonly used crosslinking techniques are also discussed in detail.
A copper-catalyzed insertion of sulfur dioxide via radical coupling
Authors: Zhang Jun , Yang Min , Liu Jin-Biao , He Fu-Sheng , Wu Jie
Published: February 2020

A copper-catalyzed reaction of O-acyl oximes, DABCO·(SO2)2, and 2H-azirines is developed under mild conditions, leading to diverse tetrasubstituted β-sulfonyl N-unprotected enamines with excellent stereoselectivity and regioselectivity.
Asymmetric synthesis of quaternary α-trifluoromethyl α-amino acids by Ir-catalyzed allylation followed by kinetic resolution
Authors: Sun Xi-Shang , Ou-Yang Qiu , Xu Shi-Ming , Wang Xing-Heng , Tao Hai-Yan , Chung Lung Wa , Wang Chun-Jiang
Published: February 2020

Facile access to quaternary α-trifluoromethyl α-amino acids has been developed. This sequential reaction involves an Ir-catalyzed asymmetric allylation of α-trifluoromethyl aldimine esters followed by an unprecedented kinetic resolution.
Correction: A silver–manganese dual co-catalyst for selective reduction of carbon dioxide into carbon monoxide over a potassium hexatitanate photocatalyst with water
Authors: Zhu Xing , Yamamoto Akira , Imai Shota , Tanaka Atsuhiro , Kominami Hiroshi , Yoshida Hisao
Published: February 2020

Correction for ‘A silver–manganese dual co-catalyst for selective reduction of carbon dioxide into carbon monoxide over a potassium hexatitanate photocatalyst with water’ by Xing Zhu et al., Chem. Commun., 2019, 55, 13514–13517.
Modulating the luminance of organic light-emitting diodes via optical stimulation of a photochromic molecular monolayer at transparent oxide electrode
Authors: Ligorio Giovanni , Cotella Giovanni F. , Bonasera Aurelio , Zorn Morales Nicolas , Carnicella Giuseppe , Kobin Björn , Wang Qiankun , Koch Norbert , Hecht Stefan , List-Kratochvil Emil J. W. , Cacialli Franco
Published: February 2020

Molecular switches reversibly change isomeric configuration upon external stimuli. Chemically bound monolayer on electrodes can allow for adding multifunctionality to devices. As a proof-of-concept this approach is employed in a light emitting diode.
NaV6O15 microflowers as a stable cathode material for high-performance aqueous zinc-ion batteries
Authors: Li Runxia , Guan Chao , Bian Xiaofei , Yu Xin , Hu Fang
Published: February 2020

NaV6O15 microflowers were synthesized as a stable cathode material for aqueous zinc ion batteries, which show a high specific capacity and excellent long-term cycling performance.
Correction: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA
Authors: Archer Stuart A. , Raza Ahtasham , Dröge Fabian , Robertson Craig , Auty Alexander J. , Chekulaev Dimitri , Weinstein Julia A. , Keane Theo , Meijer Anthony J. H. M. , Haycock John W. , MacNeil Sheila , Thomas James A.
Published: February 2020

Correction for ‘A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA’ by Stuart A. Archer et al., Chem. Sci., 2019, 10, 3502–3513.
Synergistic optimization of thermoelectric performance of Sb doped GeTe with a strained domain and domain boundaries
Authors: Bayikadi Khasim Saheb , Wu Chien Ting , Chen Li-Chyong , Chen Kuei-Hsien , Chou Fang-Cheng , Sankar Raman
Published: February 2020

An optimized two-step melt-quenching synthesis method is proposed for GeTe to show a highly reproducible high ZT ∼ 2.35 at 800 K (in Ge0.9Sb0.1Te) through simultaneous carrier concentration and microstructural control.
Osteogenic differentiation of mesenchymal stem cells by silica/calcium micro-galvanic effects on the titanium surface
Authors: Tan Lu , Hu Yan , Hou Yanhua , Chen Maowen , Xue Chencheng , Chen Maohua , Sun Yuting , Mu Caiyun , Luo Zhong , Cai Kaiyong
Published: February 2020

Si/CaCO3 nanoparticles were immobilized on titanium surface using micro-arc oxidation to produce micro-galvanic effects by Schottky contact for regulating the osteogenic responses of mesenchymal stem cells (MSCs).
Actin polymerization downstream of integrins: signaling pathways and mechanotransduction
Authors: Romero Stéphane , Le Clainche Christophe , Gautreau Alexis M.
Published: February 2020

A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to migrate are dictated not only by soluble growth factors, but also through the direct interaction of the cell with the surrounding extracellular matrix (ECM). Integrins and their connections to the actin cytoskeleton are crucial for monitoring cell attachment and the physical properties of the substratum. Cell adhesion dynamics are modulated in complex ways by the polymerization of branched and linear actin arrays, which in turn reinforce ECM-cytoskeleton connection. This review describes the major actin regulators, Ena/VASP proteins, formins and Arp2/3 complexes, in the context of signaling pathways downstream of integrins. We focus on the specific signaling pathways that transduce the rigidity of the substrate and which control durotaxis, i.e. directed migration of cells towards increased ECM rigidity. By doing so, we highlight several recent findings on mechanotransduction and put them into a broad integrative perspective that is the result of decades of intense research on the actin cytoskeleton and its regulation.
Novel molecular aspects of the CRISPR backbone protein ‘Cas7’ from cyanobacteria
Authors: Kalwani Prakash , Rath Devashish , Ballal Anand
Published: February 2020

The cyanobacterium Anabaena PCC 7120 shows the presence of Type I-D CRISPR system that can potentially confer adaptive immunity. The Cas7 protein (Alr1562), which forms the backbone of the type I-D surveillance complex, was characterized from Anabaena. Alr1562, showed the presence of the non-canonical RNA recognition motif and two intrinsically disordered regions (IDRs). When overexpressed in E. coli, the Alr1562 protein was soluble and could be purified by affinity chromatography, however, deletion of IDRs rendered Alr1562 completely insoluble. The purified Alr1562 was present in the dimeric or a RNA-associated higher oligomeric form, which appeared as spiral structures under electron microscope. With RNaseA and NaCl treatment, the higher oligomeric form converted to the lower oligomeric form, indicating that oligomerization occurred due to the association of Alr1562 with RNA. The secondary structure of both these forms was largely similar, resembling that of a partially folded protein. The dimeric Alr1562 was more prone to temperature-dependent aggregation than the higher oligomeric form. In vitro, the Alr1562 bound more specifically to a minimal CRISPR unit than to the non-specific RNA. Residues required for binding of Alr1562 to RNA, identified by protein modeling-based approaches, were mutated for functional validation. Interestingly, these mutant proteins, showing reduced ability to bind RNA were predominantly present in dimeric form. Alr1562 was detected with specific antiserum in Anabaena, suggesting that the type I-D system is expressed and may be functional in vivo. This is the first report that describes the characterization of a Cas protein from any photosynthetic organism.
Systematic review of computational modelling for biomechanics analysis of total knee replacement
Authors: Shu Liming , Li Shihao , Sugita Naohiko
Published: February 2020

In vitro and in vivo testing can provide insight into knee joint mechanics and implant performance. However, these methods are costly and time‐consuming, which always limits their widespread use during the design stage of the implant. This review presents a critical analysis of computational modelling (in‐silicon) techniques including (i) development of a generic model of total knee replacement (TKR) and application of material properties, loading, and boundary conditions; (ii) design and execution of computational experiments; and (iii) practical applications and significant findings. The results show that the generic model and techniques provide significant insight into the general performance of TKR but have limited explicit validation. The introduction of design‐of‐experiments, probabilistic, and neural network methodologies in computational modelling has enabled simulation at the population level. Further advances in subjective modelling appear to be limited, mainly because of the lack of subjective materials and boundary conditions. Computational modelling will increasingly be used in the preclinical testing and design of TKR. This modelling should include subjective, multi‐scale, and closely corroborated analyses to account for the variability of TKR.
Communication to a spinning CubeSat using a two‐mode planar circular array
Authors: Abbasi M.A.B. , Fusco V.F. , Naeem U.
Published: February 2020

This Letter presents a novel technique for establishing a robust communication link to a spinning un‐stabilised small satellite such as a CubeSat. The authors propose a system that involves a multimode excited planar circular array radio combined with a 360° phase shifter that can electronically track the spinning CubeSat antenna and establish a communication link. The transmitter comprises a mode‐generating Rotman lens and a circular array of microstrip patch antennas. The authors’ proposed approach combines two spatially orthogonal modes of the circular array. They first present the system architecture, then they design and realise a proof‐of‐concept experimentally validated module operating in C‐band at 5.8 GHz.
High accuracy phase‐matching delay estimation method based on phase correction
Authors: Lu Jun , Zhang Qunfei , Shi Wentao , Zhang Lingling
Published: February 2020

In the integrated system of underwater single‐node detection and communication, active self‐interference cancellation requires high accuracy of time delay estimation. To solve this problem, this Letter proposes a high accuracy delay estimation method based on phase correction. Initially, the normalised frequency correction is calculated according to the phase difference and time delay of the signal. Then, the discrete spectrum is reconstructed, and the phase is obtained by the least square method. Finally, the time delay is estimated by the phase difference between the received signal and the reference signal. This method corrects the phase and frequency errors caused by the Fourier transform and improves the accuracy of time delay estimation. Simulation results confirm the efficacy of the proposed method and achieve the accuracy requirement of the active self‐interference cancellation.
Synthesisable glitch‐less phase rotator with conditionally cascading scheme
Authors: Kim Hyojun , Lee Kwangho , Jeong Deog‐Kyoon
Published: February 2020

This Letter presents a synthesisable phase rotator (PR) which operates without switching glitches that are reported in conventional implementations. The proposed conditionally cascading PR (CCPR) is comprised of two multiplexers (MUXes) with logic gates, and a phase interpolator (PI). This composition enables the automatic design flow through hardware description language which shortens the design time. With the MUXes operating as a cascaded PI at transition points, the proposed CCPR outputs a clock without any transient anomaly. A remarkable reduction in power and area is achieved by sharing a common PI for every pair of input clocks and merging low pass filters into the MUXes. Simulated in a 40‐nm technology, the proposed CCPR consumes 1.9 mW at a 1.1 V supply with 5.4 GHz operation.
Ranking of keyword‐combined searches in relational databases based on relevance to the user query
Authors: Loh W.‐K. , Kwon H.‐Y.
Published: February 2020

In this Letter, the authors deal with ranking of keyword‐combined searches in relational databases based on relevance to the user query, which they call KEYSIM searches. They formally define KEYSIM searches and propose a threshold‐based method for efficiently processing KEYSIM searches. Their proposed method is the first one to find top‐k results considering both numerical similarity and textual similarity. Through the experiments using five real and synthetic data sets, they show the efficiency and scalability of the proposed method.
Spiking neural network approaches PCA with metaheuristics
Authors: Enríquez‐Gaytán J. , Gómez‐Castañeda F. , Flores‐Nava L.M. , Moreno‐Cadenas J.A.
Published: February 2020

This Letter presents meaningful results that demonstrate the reduction of dimensionality by spiking neural networks (SNNs) on benchmarking data. This experimental scheme includes metaheuristics, namely, the artificial bee colony algorithm (ABC algorithm) for finding optimal conductance values in the SNNs. Therefore, the objective function in the used ABC algorithm leads the SNNs to compute the principal component analysis (PCA), efficiently. The eigendecomposition of the information drawn by the SNNs in the training phase is the base of the formulated objective function. In these experiments, the Izhikevich model represents the spiking neurons, which have biological plausibility with parameters for reproducing a uniform firing rate. The visualisation of clusters in the 3D PCA space, whose sample values are compared with the PCA function in Matlab, is also shown; this comparison demonstrates an acceptable error in the MSE sense.
Efficacy and safety of modified endoscopic mucosal resection for rectal neuroendocrine tumors: a meta-analysis
Authors: Zheng Jian-Chun , Zheng Kai , Zhao Shuai , Wang Zhen-Ning , Xu Hui-Mian , Jiang Cheng-Gang
Published: February 2020

Purpose Rectal neuroendocrine tumors are rare with good prognosis. Several endoscopic methods such as endoscopic polypectomy, endoscopic submucosal dissection (ESD), endoscopic mucosal resection (EMR), and modified endoscopic mucosal resection (m-EMR) are used in the treatment of rectal neuroendocrine tumors. Although m-EMR is derived from traditional EMR, it has not been widely used in clinical practice. In this study, we compared the efficacy and safety of EMR and m-EMR in the treatment of rectal neuroendocrine tumors by performing a meta-analysis.

Materials and Methods We searched PubMed, Web of Science, and EMBASE index up to the end of January 2017 for all published literature about EMR and m-EMR in the treatment of rectal neuroendocrine tumors.

Results A total of 11 studies involving 811 patients were included. The pooled data suggested that there was a significantly higher rate of histologic complete resection and endoscopic complete resection among patients treated with m-EMR than those treated with EMR (histologic complete resection: OR = 0.23, 95 % CI = 0.10–0.51, p < 0.01; endoscopic complete resection: OR = 0.13, 95 % CI = 0.02–0.74, p = 0.02). The procedure time of EMR was longer than m-EMR (MD = 2.40, 95 % CI = 0.33–4.46, p = 0.02). There was a significantly higher rate of vertical margin involvement among patients treated with EMR than those treated with m-EMR; whereas, there was no significant difference of lateral margin involvement between the m-EMR and EMR groups (vertical margin involvement: OR = 5.00, 95 % CI = 2.67–9.33, p < 0.01; lateral margin involvement: OR = 1.44, 95 % CI = 0.48–4.37, p = 0.52). There was no significant difference in mean tumor size among patients treated with m-EMR versus those treated with EMR (MD = −0.30, 95 % CI = −0.75–0.14, p = 0.18); further, there was no significant difference in endoscopic mean sizes of the tumor and pathological mean sizes of the tumor between the m-EMR and EMR groups (endoscopic mean sizes of the tumor: MD = 0.20, 95 % CI = −0.44–0.84, p = 0.43; pathological mean sizes of the tumor: MD = 0.62, 95 % CI = −0.68–1.92, p = 0.05). No significant differences were detected among the treatment groups with regard to complications (bleeding: OR = 0.87, 95 % CI = 0.39–1.95, p = 0.73; complications (bleeding and perforation): OR = 0.87, 95 % CI = 0.40–1.88, p = 0.73).

Conclusion The efficacy of m-EMR are better than EMR among patients undergoing endoscopic treatment of rectal neuroendocrine tumors, and the safety of m-EMR is equivalent to EMR treatment.
Mit einem komplexen Herzfehler aufwachsen
Authors: Lindemann-Wittke Dagmar
Published: February 2020

Svea Thiedemann lebt mit einem hypoplastischen Linksherzsyndrom. Die mittlerweile 23-Jährige wurde seit ihrer Geburt immer wieder operiert, sie hat diverse Untersuchungen im Herzkatheterlabor hinter sich und im MRT. Der folgende Beitrag beleuchtet Sveas Weg und lässt die Mutter und Svea selbst zu Wort kommen, was es bedeutet, mit HLHS zu leben.
Akademisierung sichtbar machen – TheraThesisLink: Volltextdatenbank für Absolventen
Authors: Sophia Laquai
Published: February 2020

Studenten therapiewissenschaftlicher Studiengänge haben es schwer, ihre Abschlussarbeiten zu publizieren. Nur wenige Ergebnisse schaffen es als Artikel in ein wissenschaftliches Journal. Ein Projekt der Hochschule Osnabrück will das ändern und eine Volltextdatenbank etablieren.
Aufbruch in eine Welt jenseits von p < 0,05
Authors: Vielitz Arne
Published: February 2020

Wasserstein RL, Schirm AL, Lazar NA. Moving to a World Beyond “p < 0.05”. American Statistician 2019; 73 (sup1): 1–19. doi: 10.1080/00031305.2019.1583913
11 Best-Practice-Empfehlungen für die muskuloskelettale Therapie
Authors: Vielitz Arne
Published: February 2020

Lin I, Wiles L, Waller R et al. What does best practice care for musculoskeletal pain look like? Eleven consistent recommendations from high-quality clinical
practice guidelines: systematic review. Br J Sports Med. 2019 Mar 2. pii: bjsports-2018–099878. doi: 10.1136/bjsports-2018–099878. [Epub ahead of print]
Diagnostische Herausforderungen bei Mischstaub-Pneumokoniosen – 5 Fallbeispiele
Authors: Baur X.
Published: February 2020

Die Exposition gegenüber granulären und faserförmigen anorganischen alveolengängigen Stäuben führt zu inflammatorischen und fibrosierenden Lungenveränderungen. Außerdem geht sie mit einem erhöhten Lungenkrebsrisiko einher. Unter Berücksichtigung einer eingehenden Arbeitsanamnese bereitet die Diagnose der relativ häufigen Pneumokoniosen Silikose und Asbestose bei vorherrschender Ausprägung mit vorwiegend rundlichen bzw. irregulären Verschattungen und Betonung der Ober- bzw. Unterfelder kaum Schwierigkeiten. Jedoch liegt im einzelnen Erkrankungsfall selten eine Monoexposition vor. Vielmehr finden sich praktisch immer gleichzeitig Mischexpositionen, z. B. im Steinkohlenbergbau Quarz und Kohlenstoff, im Baugewerbe Quarz, Asbest, verschiedene weitere Zement- und Betonbestandteile, z. T. auch Hartmetalle und Schweißrauche. Des Weiteren kommt es im Laufe eines Arbeitslebens durch Veränderungen der Produktionsprozesse und der Ausgangsmaterialien und infolge Arbeitsplatz-/Berufswechsel zu Variationen der Art und Intensität solcher Belastungen. Die damit einhergehende Heterogenität der Exposition und der damit verbundenen intrapulmonalen Deposition hat Einfluss auf die resultierenden strukturellen Lungenveränderungen, d. h. es kommt zu mehr oder weniger ausgeprägten Abweichungen der morphologischen Strukturen von in den Lehrbüchern als typisch dargestellten Pneumokoniosebildern. Dadurch kann sich die Diagnostik schwierig gestalten, insbesondere die Abgrenzung zu idiopathischen interstitiellen Lungenerkrankungen gelingt oft nicht mehr sicher. Zu berücksichtigen sind außerdem genetische Einflüsse hinsichtlich der Krankheitssuszeptibilität und des Ausmaßes der pathohistologisch und radiologisch feststellbaren Veränderungen.

Es werden 5 Fallbeispiele dargestellt, die durchwegs initial als idiopathische Lungenfibrose gedeutet wurden, deren genaue Aufarbeitung – großteils im Rahmen der Sozialgerichtsbarkeit − durch den Autor jedoch stets eine Mischstaub-Pneumokoniose wahrscheinlich machte.
Spitzengefühl beweisen – Semmes-Weinstein Monofilament Test
Authors: Schormann Niklas
Published: February 2020

Physiotherapeuten begegnen immer wieder Patienten, die von eingeschränkter Sensibilität in Händen und Füßen berichten. Um das Ausmaß der Einschränkungen zu bestimmen und Rückschlüsse auf die zugrunde liegende Schädigung ziehen zu können, steht der Semmes-Weinstein Monofilament Test zur Verfügung.
Class I and II Histone Deacetylase Inhibitor LBH589 Promotes Endocrine
Differentiation in Bone Marrow Derived Human Mesenchymal Stem Cells and Suppresses
Uncontrolled Proliferation
Authors: Schröder Christoph , Khatri Rahul , Petry Sebastian Friedrich , Linn Thomas
Published: February 2020

Mesenchymal stem cells are useful tools employed in clinical and preclinical medicine.
Their beneficial potential in especially degenerative as well as autoimmune diseases is
a constant focus of research. Regarding diabetes mellitus, transplantation of stem cells
is seen as a possible therapeutic approach to overcome the loss of endocrine pancreatic
cells. It was reported that co-transplantation of mesenchymal stem cells with pancreatic
islet cells improves function and survival of the graft. However, these multipotent
progenitors may be able to form tumors, especially under immunosuppressed conditions.
Histone deacetylase inhibitors might offer the potential to overcome this issue. These
small molecules can induce cell differentiation and control proliferation. Their
potential to control lineage development of stem cells has been distinctly demonstrated
in the treatment of cancer, mainly in hematopoietic neoplasias.

In this study, we demonstrate that human bone marrow-derived mesenchymal stem cells
exhibit low carcinogenic potential in an immunosuppressed condition in vivo.
Further, the effect of histone deacetylase inhibitors LBH589, MS-275, and MGCD0103 was
examined after normalizing histone deacetylase activities in culture. Interestingly,
transcripts of insulin gene enhancer protein and paired-box-gene 6, two markers of
pancreatic endocrine differentiation were constitutively expressed in the cell line. The
broad spectrum inhibitor of class I and class II histone deacetylases LBH589 upregulated
the expression of these transcription factors in a significant way, whereas addition of
selective class I histone deacetylase inhibitors MS-275 and MGCD0103 did not result in
significant changes in gene expression.

In conclusion, we deliver evidence that a combined class I and II histone deacetylase
inhibition is able to modulate the transcripts of differentiation markers of mesenchymal
stem cells. The treatment holds the capability to facilitate endocrine differentiation
in future approaches to replace endocrine cells by stem cell therapy.
Synthesis of 4-Vinyl-1,2,3,4-tetrahydroisoquinoline from N-Tethered Benzyl-Alkenol Catalyzed by Indium(III) Chloride: Formal Synthesis of (±)-Isocyclocelabenzine
Authors: Saikia Anil K. , Devi Ngangbam Renubala , Shit Sudip , Behera Bipin Kumar
Published: February 2020

An intramolecular Friedel–Crafts cyclization reaction catalyzed by indium(III) chloride for the formation of 4-vinyl-1,2,3,4-tetrahydroisoquinoline from N-tethered benzyl-alkenol in good yields has been described. The reaction is highly regioselective and generates an exocyclic vinyl functionality in the piperidine ring. The reaction is compatible with a wide range of functional groups. The strategy is demonstrated for the formal synthesis of (±)-isocyclocelabenzine alkaloid.
Parents Matter: Examination of Family Presence in the Neonatal Intensive Care Unit
Authors: Saxton Sage N. , Walker Bethany L. , Dukhovny Dmitry
Published: February 2020

Objective The aim of this study is to examine presence trends for parents and family members during an infant's Neonatal Intensive Care Unit (NICU) hospitalization.

Study Design We conducted a review of 386 infants hospitalized in a Level IV NICU in the Northwestern United States between June 2013 and April 2014 to quantitatively examine presence trends.

Results Infants were visited by multiple family members. The father was the most common first family member at the bedside after admission. Parents were present over half of the days their infants were in the NICU (medians: mothers 75% and fathers 59%), but a relatively small percentage of the total hospitalization time (medians: 10% mothers and 5% fathers). Fathers', grandmothers', and grandfathers' presence with their infants in the NICU were negatively correlated with infants' total length of stay in the NICU. This finding was not replicated for mothers. Female family members were present in the NICU more than male family members.

Conclusion Parents are present a small percent of the time their infants are hospitalized in the NICU. NICU based methods to improve family presence may lead to improved patient and family centered care.

Key Points
Umbilical Blood Levels of IL-6 and TNF-α as Predictors of the Central Nervous System Damage and Retinopathy in Preterm Infants
Authors: Bartkevičienė Daiva , Pilypienė Ingrida , Serapinas Danielius , Vaigauskaitė Brigita , Vankevičiūtė Rasa Aurelija , Bartkevičiūtė Agnė , Narkevičiūtė Ieva , Dumalakienė Irena
Published: February 2020

Objective The aim was to identify the critical levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor-A in umbilical cord blood that could be used as markers for predicting the central nervous system (CNS) damage and retinopathy of prematurity (ROP) in preterm infants.

Study Design A total of 158 preterm infants, born at 22 to 34 weeks of gestation, were evaluated in the first week after birth and at 36 to 37 weeks of postconceptual age.

Results A significant relationship between CNS changes and concentrations of IL-6 (p < 0.001) and TNF-α (p < 0.001) in umbilical cord blood at 22 to 34 weeks of gestation was determined. The concentration of IL-6 >13.0 pg/mL predicts significant CNS damages in 36 to 37-week infants (p = 0.013). ROP was diagnosed in 24.8% infants (n = 149). It was detected that the levels of TNF-α >116.4 pg/mL (p < 0.001) and IL-6 >13.0 pg/mL (p < 0.05) in umbilical cord blood could predict 2 to 3/3 to 4 stages of ROP.

Conclusion Critical values of IL-6 and TNF-α in predicting ≥grade III intraventricular hemorrhage in the early adaptation and in predicting marked CNS damages and severe ROP stages in the later adaptation of preterm infants were determined.
Use of the World Health Organization Access, Watch, and Reserve Classification to Follow Trends in Prescription of Antibiotic Use in Two Pediatric Intensive Care Units in Rio de Janeiro, Brazil
Authors: Araujo da Silva André Ricardo , Oliveira Cristina Vieira de Souza , Teixeira Cristiane Henriques , Leal Izabel Alves
Published: February 2020

Objective The recommended percentage of antibiotic use in pediatric intensive care units (PICUs) using the World Health Organization (WHO) Access, Watch, and Reserve (AWaRE) classification is not known.

Methods We have conducted an interrupted time series analysis in two PICUs in Rio de Janeiro, Brazil, over a period of 18 months. The type of antibiotics used was evaluated using the WHO AWaRE classification, and the amount of antibiotic was measured using days of therapy/1,000 patient-days (DOT/1000PD) after implementation of an antimicrobial stewardship program (ASP). The first and last semesters were compared using medians and the Mann–Whitney's test. The trends of antibiotic consumption were performed using time series analysis in three consecutive 6-month periods.

Results A total of 2,205 patients were admitted, accounting for 12,490 patient-days. In PICU 1, overall antibiotic consumption (in DOT/1000PD) was 1,322 in the first 6 months of analysis and 1,264.5 in the last 6 months (p = 0.81). In PICU 2, the consumption for the same period was 1,638.5 and 1,344.5, respectively (p = 0.031). In PICU 1, the antibiotics classified in the AWaRE groups were used 33.2, 57.9, and 8.4% of the time, respectively. The remaining 0.5% of antibiotics used were not classified in any of these groups. In PICU 2, the AWaRE groups corresponded to 30.2, 60.5, and 9.3% of all antibiotics used, respectively. There was no use of unclassified antibiotics in this unit. The use of all three groups of WHO AWaRE antibiotics was similar in the first and the last semesters, with the exception of Reserve group in PICU 2 (183.5 × 92, p = 0.031).

Conclusion A significant reduction of overall antibiotic use and also in the Reserve group was achieved in one of the PICU units studied. The antibiotics classified in the Watch group were the most used in both units, representing ∼60% of all the antibiotics consumed.
Exact non-symmetric closed line vacuum magnetic fields in a topological torus
Authors: Weitzner Harold , Sengupta Wrick
Published: February 2020

Non-symmetric vacuum magnetic fields with closed magnetic field lines are of interest in the construction of stellarator equilibria. Beyond the result of D. Lortz, Z. Angew Math. Phys. 21, 196 (1970), few results are available. This work presents a closed-form expression for a class of vacuum magnetic fields in a topological torus with closed field lines. We explicitly obtain the invariants of such a field. We finally show that a three-dimensional low beta magnetohydrodynamic equilibrium may be constructed in a topological torus, starting with these closed line vacuum magnetic fields.
Delamination and current-carrying degradation behavior of epoxy-impregnated superconducting coil winding with 2G HTS tape caused by thermal stress
Authors: Duan Yujie , Gao Yuanwen
Published: February 2020

A thermo-mechanical-electromagnetic model is developed for estimating the delamination and current-carrying degradation of epoxy-impregnated pancake coils. The mixed-mode traction–separation law and the Weibull distribution of delamination strength are considered in simulating the onset and extension of the delamination caused by thermal stress. Because of the considerable differences in thermal shrinkage between the epoxy resin, insulation tape, and second-generation high temperature superconducting (2G HTS) tape, the accumulated radial thermal stress locally exceeds the electro-mechanical delamination strength and even the mechanical delamination strength. The electro-mechanical delamination strength of the 2G HTS tape is the transverse tensile or shear stress level corresponding to an abrupt irreversible critical current degradation. The mechanical delamination strength is the transverse tensile or shear stress limit corresponding to a structural failure. After injecting current into the coil, we obtained the E–I curve of the coil. The critical current and n-value of the superconducting coil indicate a strong degradation after epoxy-impregnation. The current-carrying degradation precedes delamination because the electro-mechanical delamination strength is smaller than the mechanical delamination strength. The degradation is more obvious in large than in small superconducting coils because the radial thermal stress is larger. The onset of degradation depends on the minimum delamination strength, suggesting that caution is required in screening the 2G HTS tape before winding the coil. The simulation results indicate that reducing the thickness of the insulation tape and the amount of epoxy resin effectively reduces the degradation of epoxy-impregnated pancake coils.