bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Figure 6 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC
Authors: Nakazawa Mari , Harada Guilherme , Ghanem Paola , Bubie Adrian , Kiedrowski Lesli A. , Murray Joseph C. , Marrone Kristen A. , Scott Susan C. , Houseknecht Stefanie , Falcon Christina J. , Evans Patrick , Feliciano Josephine , Hann Christine L. , Ettinger David S. , Smith Kellie N. , Anagnostou Valsamo , Forde Patrick M. , Brahmer Julie R. , Levy Benjamin , Drilon Alexander , Lam Vincent K.
Published: March 2024

Kaplan-Meier curve for (A) Overall survival (OS), (B) first-line TKI progression-free survival (PFS) and (C) PFS on first-line alectinib or brigatinib by PD-L1 high (TPS > 50%) status
Supplemental Figure 3 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC
Authors: Nakazawa Mari , Harada Guilherme , Ghanem Paola , Bubie Adrian , Kiedrowski Lesli A. , Murray Joseph C. , Marrone Kristen A. , Scott Susan C. , Houseknecht Stefanie , Falcon Christina J. , Evans Patrick , Feliciano Josephine , Hann Christine L. , Ettinger David S. , Smith Kellie N. , Anagnostou Valsamo , Forde Patrick M. , Brahmer Julie R. , Levy Benjamin , Drilon Alexander , Lam Vincent K.
Published: March 2024

(A) Samples with single versus multiple ALK resistance mutations in liquid biopsy cohort. (B) Distribution of patients with multiple ALK resistance mutations across the ALK resistance cohort by fusion variant type, with percentages above each variant type column indicate the proportion of patients with multiple ALK resistance mutations. The inset chi-squared statistic demonstrates no significant association between multiple resistance mutations and variant type. (C) Distribution of most common ALK resistance co-mutation pairs
FIGURE 4 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC
Authors: Nakazawa Mari , Harada Guilherme , Ghanem Paola , Bubie Adrian , Kiedrowski Lesli A. , Murray Joseph C. , Marrone Kristen A. , Scott Susan C. , Houseknecht Stefanie , Falcon Christina J. , Evans Patrick , Feliciano Josephine , Hann Christine L. , Ettinger David S. , Smith Kellie N. , Anagnostou Valsamo , Forde Patrick M. , Brahmer Julie R. , Levy Benjamin , Drilon Alexander , Lam Vincent K.
Published: March 2024

Kaplan–Meier curve for OS (A) and PFS (B) on first-line TKI by TP53 mutation and CDKN2A/B loss.
FIGURE 3 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC
Authors: Nakazawa Mari , Harada Guilherme , Ghanem Paola , Bubie Adrian , Kiedrowski Lesli A. , Murray Joseph C. , Marrone Kristen A. , Scott Susan C. , Houseknecht Stefanie , Falcon Christina J. , Evans Patrick , Feliciano Josephine , Hann Christine L. , Ettinger David S. , Smith Kellie N. , Anagnostou Valsamo , Forde Patrick M. , Brahmer Julie R. , Levy Benjamin , Drilon Alexander , Lam Vincent K.
Published: March 2024

Kaplan–Meier curve for OS and PFS on first-line TKI by EML4-ALK v3 status (A). B, OS and PFS subgroup analysis by Cox regression. HR, unadjusted hazard ratio; CI, confidence interval.
FIGURE 2 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC
Authors: Nakazawa Mari , Harada Guilherme , Ghanem Paola , Bubie Adrian , Kiedrowski Lesli A. , Murray Joseph C. , Marrone Kristen A. , Scott Susan C. , Houseknecht Stefanie , Falcon Christina J. , Evans Patrick , Feliciano Josephine , Hann Christine L. , Ettinger David S. , Smith Kellie N. , Anagnostou Valsamo , Forde Patrick M. , Brahmer Julie R. , Levy Benjamin , Drilon Alexander , Lam Vincent K.
Published: March 2024

ALK resistance mutations observed in clinical (n = 26; A) and liquid biopsy (n = 202; B) cohorts, by patient (columns) and grouped by EML4-ALK variant type. Filled regions of the oncoprint indicate presence of the ALK resistance mutation designated by the row name for a given patient. Resistance mutation percentages indicate share of each among total patients, by cohort. Both G1202R and I1171N are associated with EML4-ALK v3 and L1196M is associated with EML4-ALK non-v3.
FIGURE 1 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC
Authors: Nakazawa Mari , Harada Guilherme , Ghanem Paola , Bubie Adrian , Kiedrowski Lesli A. , Murray Joseph C. , Marrone Kristen A. , Scott Susan C. , Houseknecht Stefanie , Falcon Christina J. , Evans Patrick , Feliciano Josephine , Hann Christine L. , Ettinger David S. , Smith Kellie N. , Anagnostou Valsamo , Forde Patrick M. , Brahmer Julie R. , Levy Benjamin , Drilon Alexander , Lam Vincent K.
Published: March 2024

A,EML4-ALK variant type observed in clinical and liquid biopsy cohorts. B, Clinically relevant somatic co-mutations observed in clinical and liquid biopsy (LB) cohorts. Copy-number deletion/loss not reported in the liquid biopsy cohort; loss-of-function mutations in CDKN2A/B, PTEN, and CTNNB1 are included.
The Application of Regional Citrate Anticoagulation in Protein A Immunoadsorption: A Single-Center Retrospective Cohort Study
Authors: Muhammad Amir , Hu Xueling , Pan Juan , Peng Weisheng , Li Xia , Huang Mingxia , Luo Zengyuan , Jiang Dayang , Chen Jinbiao , Tang Rong , Xiao Xiangcheng
Published: March 2024

Introduction: Protein A immunoadsorption (IA) is proving to be an effective treatment method for autoimmune diseases and other disorders. Regional citrate anticoagulation (RCA) prevents clotting in extracorporeal circuits without increasing hemorrhage risk in high bleeding risk patients, but there are no specific guidelines for its application in IA. We aimed to evaluate the safety and adverse effects of RCA used in IA therapy. Methods: We conducted a retrospective cohort study of forty-five RCA-IA sessions in 14 HLA-incompatible kidney transplant recipients with focus on the safety and adverse effects of RCA in IA. The extracorporeal circuit was equipped with 4% trisodium citrate solution as an anticoagulant and 10% calcium gluconate solution to compensate for calcium loss. The adverse events, including coagulation and blood biochemical indexes, especially calcium level, were recorded. Results: Our study found that 93.33% of the sessions were without circuit clotting or other significant complications. A slight decrease in fibrinogen level was observed, but without significant variations in other coagulation indexes or platelet count. There was a slight elevation in the potential of hydrogen, bicarbonate, and base excess after 2 h and 6 h posttreatment relative to prior treatment, but these returned to normal levels within 24 h posttreatment. Conclusion: RCA is a feasible, effective, and safe anticoagulation option for IA treatment in HLA-incompatible kidney transplant recipients. Electrolyte disturbances, especially alkalosis, hypocalcemia, hypomagnesemia, and fluid status, should be closely monitored and managed.
Acquired von Willebrand Syndrome Associated with a Smoldering Multiple Myeloma, Successfully Treated by Daratumumab, Lenalidomide, and Dexamethasone
Authors: Iarossi Michael , Vekemans Marie-Christiane Madeleine , Weynants Nicolas , Hermans Cedric
Published: March 2024

Introduction: Acquired von Willebrand syndrome (AvWS) is a rare entity with approximately 700 cases described in the literature. A number of etiologies are responsible for this condition, mainly lymphoproliferative, myeloproliferative syndromes and cardiac diseases. Management is aimed at preventing and treating bleeds, as well as treating the underlying pathology. In the case of a monoclonal gammopathy, there are limited evidence and high heterogeneity only based on old case reports, resulting in poor quality recommendations. It seems essential in 2023 to take into account and offer the new anti-myeloma treatments available. Case Presentation: We describe the case of a patient with an AvWS secondary to an IgG smoldering multiple myeloma, experiencing multiple bleeding, treated successfully with daratumumab, lenalidomide, and dexamethasone, after multiple treatment failure. Conclusion: Daratumumab, lenalidomide, and dexamethasone was demonstrated as a rapid and effective treatment for a patient with severe AvWS and multiple bleeding complications.
Bacterial Skin Dysbiosis in Darier Disease
Authors: Reiter Ofer , Leshem Avner , Alexander-Shani Rivka , Brandwein Michael , Cohen Yotam , Yeshurun Algit , Ziv Michael , Elinav Eran , Hodak Emmilia , Dodiuk-Gad Roni P.
Published: March 2024

Introduction: Darier disease is a rare inherited disease with dominant skin manifestations including keratotic papules and plaques on sebaceous and flexural areas. Secondary infection of skin lesions is common, and Staphylococcus aureus commonly colonizes these lesions. The aim of the study was to characterize the bacterial microbiome of cutaneous Darier lesions compared to normal-looking skin and disease severity. Methods: All patients with a history of Darier followed up at Emek Medical Center were invited to participate in the study. Patients that did not use antibiotics in the past month and signed informed consent had four skin sites sampled with swabs: scalp, chest, axilla, and palm. All samples were analyzed for bacterial microbiome using 16S rDNA sequencing. Results: Two hundred and eighty microbiome samples obtained from lesional and non-lesional skin of the scalp, chest, axilla, and palm of 42 Darier patients were included in the analysis. The most abundant bacterial genera across all skin sites were Propionibacterium, Corynebacterium, Paracoccus, Micrococcus, and Anaerococcus. Scalp and chest lesions featured a distinct microbiome configuration that was mainly driven by an overabundance of Staphylococci species. Patients with more severe disease exhibited microbiome alterations in the chest, axilla, and palm compared with patients with only mild disease, driven by Peptoniphilus and Moryella genera in scalp and palmar lesions, respectively. Conclusion: Staphylococci were significantly associated with Darier lesions and drove Darier-associated dysbiosis. Severity of the disease was associated with two other bacterial genera. Whether these associations also hold a causative role and may serve as a therapeutic target remains to be determined and requires further investigation.
Enhanced Survival with Lymphadenectomy in Early-Stage Metachronous Second Primary Lung Cancer: A Retrospective Analysis
Authors: Zhang Jieshi , Lin Yuxiao , Zhou Jiong , Geng Ruixuan , Zheng Zhibo , Guo Chao , Ma Xiaojun , Li Shanqing
Published: March 2024

Introduction: Lymphadenectomy is a cornerstone in the surgical management of resectable primary lung cancer. However, its prognostic significance in early-stage metachronous second primary lung cancer (MSPLC) remains poorly understood. This retrospective study aimed to evaluate the prognostic impact of lymphadenectomy in these patients using data from the Surveillance, Epidemiology, and End Results (SEER) Database. Methods: A retrospective cohort study was conducted using data from the SEER Database for patients surgically treated for stage I MSPLC between 2004 and 2015. Propensity score-matching was employed to create comparable cohorts, and the Cox proportional hazards model was utilized to estimate the hazard ratio (HR) for overall survival after lymphadenectomy compared to non-lymphadenectomy. Survival analysis was performed using Kaplan-Meier curves and the log-rank test. Results: Among 920 identified patients with MSPLC, 574 (62.4%) underwent lymphadenectomy. Propensity score-matching yielded 255 patients in both the lymphadenectomy and non-lymphadenectomy groups. Over a median follow-up of 38 months, the 5-year overall survival probability after a diagnosis of MSPLC was 58.7% in the lymphadenectomy group and 43.9% in the non-lymphadenectomy group (HR: 0.76; 95% confidence interval 0.64–0.90; p = 0.002). Conclusion: In this population-based study, lymphadenectomy is associated with prolonged overall survival in patients with stage I MSPLC. These findings suggest the potential benefit of incorporating lymphadenectomy into the surgical management of MSPLC, providing valuable guidance for thoracic surgeons in clinical decision-making.
The Use of Tetrahydrocannabinol Is Associated with an Increase in Survival Time in Palliative Cancer Patients: A Retrospective Multicenter Cohort Study
Authors: Gastmeier Knud , Gastmeier Anne , Schwab Frank , Herdegen Thomas
Published: March 2024

Introduction: Tetrahydrocannabinol (THC) is often prescribed for ambulatory palliative patients to improve sleep quality and appetite and to reduce anxiety, stress, and pain. However, it is not known if THC has also an effect on the mortality of these patients. Method: The objective was the impact of THC on mortality of ambulatory palliative patients. For this purpose, data from the palliative treatment documentation from 5 ambulatory palliative care teams in Brandenburg, Germany were used for this analysis. Survival time was calculated for 3 groups of patients: (1) without THC; (2) with THC in a low dosage (≤4.7 mg per day); and (3) THC in higher doses (≥4.7 mg per day). The analysis was done for 2 cohorts of patients. Cohort 1: all patients with a survival time of at least 7 days after inclusion in specialized ambulatory palliative care (SAPC) and cohort 2: a subgroup of patients with a survival time between 7 and 100 days. Kaplan-Meier curves were created, and multivariate analysis was done to investigate the impact of THC on mortality. Results: A total of 9,419 patients with a survival time of at least 7 days after inclusion in SAPC were included in the analysis (cohort 1). 7,085 among them had a survival time between 7 and 100 days (cohort 2). In both cohorts, survival time was significantly prolonged by THC, but only when the daily THC dose was above the median of 4.7 mg. Survival time was 15 days longer in cohort 2 (40 vs. 25 days), when more than 4.7 mg THC were prescribed per day. Conclusion: Use of THC is associated with a significant increase in survival time in ambulatory palliative patients which survive longer than 7 days the initiation of THC prescription and which use of THC >4.7 mg/day.
Perbaikan Kualitas Lahan untuk Kebun Kopi Rakyat
Authors: Soemarno S , Prijono Sugeng , Ifadah Nisfi Fariatul , Ramadhani Muhammad Hibatullah , Alfathin Syifa Chairani , Maulana Miko , Sasmita Nanda Ayu , Latifah Hanif
Published: March 2024

Indonesia merupakan produsen kopi terbesar ke empat di dunia pada tahun 2014. Kopi di Indonesia dimulai dengan sejarah kolonialnya, dan telah memainkan peranan penting dalam pertumbuhan negara. Indonesia menghasilkan sekitar 540.000 metrik ton kopi pada tahun 2014. Dari jumlah ini, diperkirakan bahwa 154.800 ton diperlukan untuk konsumsi domestik di tahun keuangan 2013/2014. Dari ekspor, 25% adalah biji kopi arabika; sisanya adalah kopi robusta. Secara umum, kopi arabika Indonesia memiliki keasaman rendah dan aroma yang kuat, yang membuatnya ideal untuk dicampur dengan kopi dengan keasaman yang lebih tinggi dari Amerika Tengah dan Afrika Timur. Pada saat ini, lebih dari 90% kopi Indonesia ditanam oleh petani kecil (kebun kopi rakyat) di lahan-lahan pertanian rata-rata seluas satu hektar. Sebagian dari produksi ini bersifat organik dan banyak koperasi petani dan eksportir secara internasional bersertifikat untuk memasarkan kopi organik. Ada lebih dari 20 varietas Coffea arabica yang ditanam secara komersial di Indonesia. Kekurangan air di musim kemarau merupakan permasalahan utama yang dihadapi oleh petani kopi di Indonesia. Permasalahan tersebut tentu saja dapat berdampak pada produksi tanaman kopi tahunan, Kekurangan air pada lahan disebabkan oleh berubahnya sifat fisik tanah yang diakibatkan oleh kurangnya aplikasi bahan organik pada lahan sehingga air yang masuk pada lahan sebagian besar terlimpas dan hanya sebagian kecil yang dapat disimpan dalam tanah. Buku Memperbaiki Kualitas Lahan untuk Kebun Kopi Rakyat ini disusun sebagai bahan untuk memahami pengetahuan tentang perbaikan kualitas lahan untuk kebun kopi baik dari sifat kimia, fisika, dan biologi tanah serta secara khusus meliputi peran pemberian bahan organik dalam tanah dalam memperbaiki kualitas tanah dan beberapa jenis bahan organik yang dapat dimanfaatkan dalam peningkatan kandungan karbon tanah dan nitrogen, fosfor, dan kalium yang dapat meningkatkan pertumbuhan dan produksi tanaman.
Pengantar Ekonomi Pertanian
Authors: Hanani Nuhfil , Syafrial Syafrial , Suhartini S , Toiba Hery , Asmara Rosihan , Sujarwo S , Nugroho Tri Wahyu , Fahriyah F , Andajani Tatiek Koerniawati , Nugroho Condro Puspo , Mutisari Rini , Andriatmoko Novil Dedy , Widyawati Wiwit , Meitasari Deny , ‘Ula Mahfudlotul , Rahman Moh Shadiqur , Andrianto Bagus
Published: March 2024

Buku ini merupakan komprehensif yang membahas pengantar ekonomi pertanian dalam konteks Indonesia. Dengan penekanan pada karakteristik, teori, dan kebijakan sektor pertanian, buku ini memberikan wawasan yang mendalam kepada pembaca tentang dimensi pertanian di Indonesia, permasalahan dalam ekonomi pertanian, serta program-program yang mendukung sektor ini. Buku ini juga membahas konsep dasar ekonomi pertanian yang tidak hanya memfokuskan pada aspek produksi dan konsumsi dalam pertanian, tetapi juga membahas pentingnya pemasaran produk pertanian. Selain itu, membahas struktur pasar produk pertanian dan pentingnya memahami perilaku konsumen dan produsen pangan. Buku ini juga mencakup topik yang relevan dengan pembangunan pertanian, seperti pembangunan pertanian berkelanjutan, ketahanan pangan, pertanian organik, pertanian kota, serta strategi modernisasi pertanian. Melalui buku ini, diharapkan memberi wawasan pengetahuan yang berharga bagi para praktisi, mahasiswa, peneliti, serta siapa pun yang tertarik dalam memahami aspek ekonomi yang terkait dengan pertanian.
Pengembangan dan Hibridisasi Tanaman Melon
Authors: Adiredjo Afifuddin Latif , Ardiarini Noer Rahmi , Roviq Mochammad , Suyadi S
Published: March 2024

Buku ini merupakan panduan komprehensif yang membahas berbagai aspek terkait pengembangan dan hibridisasi melon. Dalam buku ini, pembaca akan diperkenalkan dengan sejumlah topik penting yang berkaitan dengan etnobotani melon, budi daya melon, serta teknik persilangan yang digunakan untuk mengembangkan melon hibrida maupun melon unggul. Pembaca akan memahami langkah-langkah yang diperlukan untuk memulai program hibridisasi melon dan bagaimana melakukan seleksi untuk mendapatkan karakteristik yang diinginkan. Selain itu, buku ini juga memberikan informasi bersifat kebaruan karena menyajikan persilangan tanaman melon pada kondisi tanaman tercekam kekeringan. Dengan demikian, terdapat wawasan yang sangat berharga mengenai cekaman yang dapat memengaruhi tanaman melon, bagaimana mengatasi tantangan tersebut, serta ciri-ciri tanaman melon yang dapat beradaptasi dengan kondisi lingkungan yang berbeda, tetapi tetap produktif. Aspek lain yang menarik dari buku ini adalah adanya studi kasus yang mendalam terkait dengan persilangan pada tanaman melon. Pembaca akan memahami bagaimana hasil sidik ragam, kemampuan daya gabung umum dan khusus, serta penilaian heterosis dapat digunakan untuk mengevaluasi kualitas hibrida yang dihasilkan dari program persilangan. Akhirnya, buku ini memberikan rekomendasi yang berharga tentang budi daya dan hibridisasi pada tanaman melon berdasarkan pengetahuan dan data yang telah dipelajari. Hal Ini akan menjadi sumber informasi bagi siapa pun yang tertarik dengan pengelolaan tanaman melon, baik sebagai petani, peneliti, praktisi, ataupun masyarakat pada umumnya.
Hysteroscopic and morphological evaluation of endometrium in
reproductive age women with comorbid polycystic ovarian syndrome and chronic
endometritis in the protocols of in vitro fertilization
Authors: Khmil Doswald Anna S. , Malanchuk Larysa M.
Published: March 2024

Summary. Today, infertility, which is associated with polycystic ovary
syndrome, is a pressing problem in obstetrics, gynecology and reproductive
medicine. Polycystic ovary syndrome (PCOS) is a common endocrine disease
that affects about 6 to 20 % of women of childbearing potential. Its main
signs are ovulatory and menstrual dysfunction (including anovulation),
increased levels of gonadotropin-releasing hormone, hypersecretion of
luteinizing hormone, hyperandrogenemia, metabolic disorders and
morphological changes in the endometrium and ovaries. The aim of the study –
to evaluate hysteroscopic and morphological changes in the endometrium of
women with infertility against the background of PCOS and chronic
endometritis and to analyze the effect of a modified treatment regimen in
the protocols of in vitro fertilization on the manifestations of chronic
endometritis. Materials and Methods. We examined 140 women with endocrine
infertility against the background of PCOS and chronic endometritis, which
were divided into 2 study groups, depending on the cause and treatment
approach for infertility, as well as 35 women with male-caused infertility
who comprised the control group. All examined patients underwent
hysteroscopy, targeted biopsy and immunohistochemical study of the
endometrium. Histological study of the endometrium was performed by staining
the tissue with hematoxylin and eosin according to a standard protocol in
order to understand the structural changes of the endometrium in women of
the study groups. Immunohistochemical testing involved the detection of
CD138 using standard Daco antibody kits (Denmark). Results. Patients with
PCOS and chronic endometritis used standard anti-inflammatory treatment
which followed our modified protocol. This resulted in significantly reduced
manifestations of chronic endometritis. The modified protocol includes
inositol and alpha-lipoic acid in pre-pregnancy preparation; PRP therapy of
the uterine cavity; and lipofundin infusions on day 2–3 of the menstrual
cycle and on the day of embryo transfer. Conclusions. Histological
examination of the endometrium with manifestations of stromal-adenomatous
polyps revealed reduced signs of cytogenic stroma proliferation, decreased
perivascular edema and the number of erythrocyte diapedesis. The number of
glandular elements and the size of the glands also decreased
Characteristics of the sleep quality, stress and anxiety during the
COVID-19 pandemic in nurses of therapeutic departments and nurses working in
departments provided help to patients with coronavirus disease COVID-19
Authors: Dvulit Mykola M. , Ya. Krynytska Inna
Published: March 2024

Summary. The coronavirus disease (COVID-19) pandemic has become a
serious experience not only for Ukrainian society, but for the whole
humanity, negatively affecting the healthcare systems of many countries and
increasing the risk of psychological disorders among medical staff. The aim
of the study – to examine the frequency and severity of sleep disorders,
stress and anxiety during the COVID-19 pandemic in nurses working in
therapeutic units and in units where patients with COVID-19 coronavirus
disease are treated. Materials and Methods. A total of 56 therapeutic
nur­ses took part in the study, of whom 30 worked in therapeutic departments
and 26 in specialized departments where care for patients with coronavirus
COVID-19 is provided. We used a subjective sleep assessment questionnaire to
clinically assess the severity of insomnia. To assess stress and anxiety
during the COVID-19 pandemic, nurses used the SAVE-9 questionnaire for
medical staff. Statistical data processing was performed using standard
“Statistica” information processing software. Results. Sleep disturbances
among the nurses of therapeutic profile who work in the departments where
care is provided to patients with COVID-19 were found in 42.3 % (n=11) of
respondents. According to the structure of sleep disorders were distributed
as follows: presomnia (sleep initiation disorders) were observed in 50.0 %
(n=13); intrasomnic (sleep support disorders) – in 30.8 % (n=4); postsomnic
(awakening disorders) – in 19.2 % (n=4); daytime sleepiness – in 30.8 %
(n=8) of respondents. An analysis of the SAVE-9 mean score in therapeutic
nurses working in COVID-19 care units found that the mean stress and anxiety
level in the study group was (14.5±0.62) points. This result is
statistically significantly higher (by 42.2 %) than in the group of nurses
of therapeutic departments (p 0.05). Conclusions. Significantly higher
levels of sleep, stress, and anxiety disorders were found in therapeutic
nurses working in COVID-19 care units than in therapeutic nurses, which
indicate the need to develop and implement a number of preventive measures
for nurses involved in providing care to patients with acute coronavirus
disease to ensure their quality and effective professional activities
Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3
Authors: Abbey Colette A. , Duran Camille L. , Chen Zhishi , Chen Yanping , Roy Sukanya , Coffell Ashley , Sveeggen Timothy M. , Chakraborty Sanjukta , Wells Gregg B. , Chang Jiang , Bayless Kayla J.
Published: March 2024

BACKGROUND:

New blood vessel formation requires endothelial cells to transition from a quiescent to an invasive phenotype. Transcriptional changes are vital for this switch, but a comprehensive genome-wide approach focused exclusively on endothelial cell sprout initiation has not been reported.

METHODS:

Using a model of human endothelial cell sprout initiation, we developed a protocol to physically separate cells that initiate the process of new blood vessel formation (invading cells) from noninvading cells. We used this model to perform multiple transcriptomics analyses from independent donors to monitor endothelial gene expression changes.

RESULTS:

Single-cell population analyses, single-cell cluster analyses, and bulk RNA sequencing revealed common transcriptomic changes associated with invading cells. We also found that collagenase digestion used to isolate single cells upregulated the Fos proto-oncogene transcription factor. Exclusion of Fos proto-oncogene expressing cells revealed a gene signature consistent with activation of signal transduction, morphogenesis, and immune responses. Many of the genes were previously shown to regulate angiogenesis and included multiple tip cell markers. Upregulation of SNAI1 (snail family transcriptional repressor 1), PTGS2 (prostaglandin synthase 2), and JUNB (JunB proto-oncogene) protein expression was confirmed in invading cells, and silencing JunB and SNAI1 significantly reduced invasion responses. Separate studies investigated rounding 3, also known as RhoE, which has not yet been implicated in angiogenesis. Silencing rounding 3 reduced endothelial invasion distance as well as filopodia length, fitting with a pathfinding role for rounding 3 via regulation of filopodial extensions. Analysis of in vivo retinal angiogenesis in
Rnd3
heterozygous mice confirmed a decrease in filopodial length compared with wild-type littermates.

CONCLUSIONS:

Validation of multiple genes, including rounding 3, revealed a functional role for this gene signature early in the angiogenic process. This study expands the list of genes associated with the acquisition of a tip cell phenotype during endothelial cell sprout initiation.
Islam, Visual Morality and Gender Identity in Cyberspace: The Agency, Controversy and Popular Piety of Ria Ricis
Authors: Barizi Ahmad , Rohmah Siti , Kholish Moh Anas , Hikmah Nurul
Published: March 2024

Hijab wearing women are often key players in the digital market ecosystem and popular culture in Indonesia, as well as being a battleground for discourse on contemporary relations between Islam and gender. By analyzing the controversy and development of Instagram celebrity and YouTuber Ria Ricis, this article discusses sexual morality and visual culture in cyberspace that shows the latest developments in the use of hijab, popular piety, and the lifestyle of young millennial Muslim women. This article seeks to contribute to refreshing the literature on Islamic studies and gender studies in Indonesia with the intersection of Islam, gender, and digital media. This study argues that in the midst of the controversy over Muslim woman’s sexual morality in Indonesian cyberspace, Ria Ricis shows her agency by positioning herself as a millennial hijabi woman with popular piety and participating in spreading Islamic messages according to the digital market ecosystem while maintaining a cheerful and sensational millennial identity and character.
Just Police Violence: Liberal ideology and the critique of violence from Walter Benjamin to Black Lives Matter
Authors: Duff Koshka
Published: March 2024

Policing is broadly legitimate – even while imperfect and in need of reform. This axiom of liberal political theory and practice is shaken by movements like Black Lives Matter, which confront and expose carceral violence as the routine, deadly edge of racial capitalism. Thinking with abolitionist currents within these movements, this paper engages critical theory to unpick the ideological discourses that legitimise police violence in ‘real existing liberalism’. I argue that justifications of policing replicate the ‘analytic atomism’ and mythologisation of law that Neu’s Just Liberal Violence identifies in defences of sweatshops, torture, and war. I bring together Benjamin’s classic excavation of sovereign power in the policing function with the experiences of today’s policed subjects to reveal the limitations of liberal appeals to ‘the rule of law’. The standard figuration of oppressive violence as exceptional, deviant, and unlawful, I argue, serves to legitimise the institutions in and through which that violence is normalised.
On the validity of the recently described northern green anaconda Eunectes akayima (Squamata, Serpentes)
Authors: Vásquez-Restrepo Juan D. , Alfonso-Rojas Andrés , Palacios-Aguilar Ricardo
Published: March 2024

Recently, a taxonomic work was published concerning the existence of a new cryptic species of green anaconda. The authors justified the recognition of a phylogenetic lineage as a new species, which they named Eunectes akayima, based on genetic and geographical distribution differences. Regardless of whether the evidence provided to justify the recognition of this new species is sufficient, the article in question violates fundamental aspects of the International Code of Zoological Nomenclature, such as the principle of priority and the rules for the designation lectotypes. Furthermore, the authors make unjustified assumptions regarding the type locality of Eunectes murinus, compromising the integrity of their nomenclatural actions. Here, we present a critique of this work grounded in the application of the rules of zoological nomenclature, leading to the synonymizing of the recently described species.
Revision of some historical types of the genus Lithobius Leach, 1814 (Chilopoda, Lithobiomorpha) from the 1949/50 Austrian Iran Expedition, with new molecular data for L. iranicus Attems, 1951
Authors: AKKARI NESRINE , MACEK OLIVER , EDGECOMBE GREGORY D.
Published: March 2024

Lithobius (Lithobius) iranicus Attems, 1951, is recorded for the first time since its original description and is rediagnosed and redescribed based on recent and type material deposited at the Naturhistorisches Museum Wien (NHMW). The revision of the species includes genetic information from three loci and modern illustrations of its key morphological characters. Restudy of the syntypes of two nominal species collected in the same expedition, Lithobius inaequidens Attems, 1951, and L. rhiknus Attems, 1951, reveals no reliable distinguishing characters from L. iranicus, with which they are placed in junior subjective synonymy. Lithobius inquiriendus Attems, 1951 is based on immature specimens from southern Iran that likely include two species, neither of which can be confidently identified as conspecific with L. iranicus. Incorporating L. iranicus in a molecular phylogeny for Lithobiidae recovers it as an isolated lineage allied to a clade of mostly Palaearctic species of Lithobius (Lithobius).
Polythore vexilla sp. nov. from southwestern Ecuador (Odonata: Polythoridae)
Authors: TENNESSEN KENNETH J.
Published: March 2024

Polythore vexilla sp. nov. (holotype ♂, allotype ♀: ECUADOR, Azuay Province, small tributary of Río Pijilí, about 4.1 km SE of Victoria, -2.940°, -79.5625°; approximate elev. 730 m, 11-IV-2008, K. J. Tennessen leg., deposited in Florida State Collection of Arthropods) belongs in the Andean clade of Polythore Calvert. Based on genital ligula morphology it appears to be most closely related to P. gigantea (Selys). The male is distinct from all congeners by the narrow, medial black band in all four wings; the central band in the female wings is similar to the male.
Two new species of the genus Orphnebius Motschulsky, 1858 from Mindanao, Philippines (Coleoptera: Staphylinidae: Aleocharinae: Lomechusini)
Authors: SHAVRIN ALEXEY V. , MEDINA MILTON NORMAN D.
Published: March 2024

Two new species of aleocharine genus Orphnebius Motschulsky, 1858 (Lomechusini: Myrmedoniina) from southeastern Mindanao are described and illustrated: O. (Deroleptus) barsevskisi Shavrin, sp. n. (Candalaga Mts.) and O. (Deroleptus) poncei Shavrin, sp. n. (Davao Oriental). The distributional map for all species of the genus known from Mindanao is also provided.
A new species of the highly modified genus Pseudocerocoma Pic, 1919 from Colombia (Coleoptera: Cantharidae: Ichthyurini)
Authors: SERNA-MUÑOZ SEBASTIAN , ALZATE-CANO JULIAN DAVID
Published: March 2024

The genus Pseudocerocoma Pic, 1919 (Coleoptera: Cantharidae: Ichthyurini) was previously recognized as a monotypic genus. Based on material from Antioquia, Colombia, we describe and illustrate Pseudocerocoma tulenapa sp. nov. It differs from the other known species of the genus in the shape of the antennae and the abdominal segment 8, as well as in some aspects of coloration. This new species provides additional evidence for the position of Pseudocerocoma Pic, 1919 as a separate genus from Malthoichthyurus Pic, 1919, also represents the first record of the tribe Ichthyurini in Colombia and shows the importance of the conservation actions carried out in the only known locality, the Tulenapa Biological Station of the Universidad de Antioquia.
Life Cycle of Precipitating Cloud Systems from Synergistic Satellite Observations: Evolution of Macrophysical Properties and Precipitation Statistics from Geostationary Cloud Tracking and GPM Active and Passive Microwave Measurements
Authors: Guilloteau Clément , Foufoula-Georgiou Efi
Published: March 2024

Observations of clouds and precipitation in the microwave domain from the active dual-frequency precipitation radar (DPR) and the passive Global Precipitation Measurement (GPM) Microwave Imager (GMI) onboard the GPM Core Observatory satellite are used in synergy with cloud tracking information derived from infrared imagery from the GOES-13 and Meteosat-7 geostationary satellites for analysis of the life cycle of precipitating cloud systems, in terms of temporal evolution of their macrophysical characteristics, in several oceanic and continental regions of the tropics. The life cycle of each one of the several hundred thousand cloud systems tracked during the 2-yr (2015–16) analysis period is divided into five equal-duration stages between initiation and dissipation. The average cloud size, precipitation intensity, precipitation top height, and convective and stratiform precipitating fractions are documented at each stage of the life cycle for different cloud categories (based upon lifetime duration). The average life cycle dynamics is found remarkably homogeneous across the different regions and is consistent with previous studies: systems peak in size around midlife; precipitation intensity and convective fraction tend to decrease continuously from the initiation stage to the dissipation. Over the three continental regions, Amazonia (AMZ), central Africa (CAF), and Sahel (SAH), at the early stages of clouds’ life cycle, precipitation estimates from the passive GMI instrument are systematically found to be 15%–40% lower than active radar estimates. By highlighting stage-dependent biases in state-of-the-art passive microwave precipitation estimates over land, we demonstrate the potential usefulness of cloud tracking information for improving retrievals and suggest new directions for the synergistic use of geostationary and low-Earth-orbiting satellite observations.
The Making of the “Good Bad” Job: How Algorithmic Management Manufactures Consent Through Constant and Confined Choices
Authors: Cameron Lindsey D.
Published: March 2024

This research explores how a new relation of production—the shift from human managers to algorithmic managers on digital platforms—manufactures workplace consent. While most research has argued that the task standardization and surveillance that accompany algorithmic management will give rise to the quintessential “bad job” (Kalleberg, Reskin, and Hudson, 2000; Kalleberg, 2011), I find that, surprisingly, many workers report liking and finding choice while working under algorithmic management. Drawing on a seven-year qualitative study of the largest sector in the gig economy, the ride-hailing industry, I describe how workers navigate being managed by an algorithm. I begin by showing how algorithms segment the work at multiple sites of human–algorithm interactions and how this configuration of the work process allows for more-frequent and narrow choice. I find that workers use two sets of tactics. In engagement tactics, individuals generally follow the algorithmic nudges and do not try to get around the system; in deviance tactics, individuals manipulate their input into the algorithmic management system. While the behaviors associated with these tactics are practical opposites, they both elicit consent, or active, enthusiastic participation by workers to align their efforts with managerial interests, and both contribute to workers seeing themselves as skillful agents. However, this choice-based consent can mask the more-structurally problematic elements of the work, contributing to the growing popularity of what I call the “good bad” job.
School principals’ role in promoting physical activity for inactive children in school settings: An exploratory study
Authors: Augustsson Felicia , Grahn Karin
Published: March 2024

Objective:

The aim of this study was to explore the school principal’s role in promoting physical activity for inactive children in school settings.

Design:

Exploratory qualitative interview study.

Setting:

The study was conducted in seven elementary schools in central Sweden.

Method:

Data were collected by means of semi-structured interviews with eight school principals. Theories of bioecology and teacher agency informed the study and shed light on the environmental factors and resources affecting school principals’ efforts to promote physical activity for inactive children.

Result:

The most common strategy school principals described was to delegate responsibility for planning organised activities to dedicated school personnel working with the children. In their leadership role, principals described having the power and opportunity to recruit school personnel with positive attitudes towards promoting physical activity, which likely increases inactive children’s opportunities to engage in PA.

Conclusion:

When provided the adequate resources, and by virtue of their management position within the school, principals have the opportunity to make a difference to promote PA for inactive children. Delegating responsibility to school personnel may however create unequal PA opportunities, and if there are no initiators dedicated to this work, inactive children may be left out of PA opportunities in school.
A roundtrip probability estimation method for mechanical equipment fault detection under imbalanced samples
Authors: Yuyan Zhang , Yongqi Zhang , Wuyi Ming , Hao Li , Xiaoyu Wen , Lingdi Yan
Published: March 2024

Aiming at high misdetection of mechanical faults under imbalanced samples, a roundtrip probability-based method is proposed. By roundtrip mapping between latent variables and real fault data, biased estimation of the probability distribution of real fault data is obtained. Further, virtual fault data are sampled according to such distribution to increase sample amount. For recognition of real and virtual data, loss function based on binary cross-entropy is designed. For reconstruction between fault data and its roundtrip mapped results, objective function based on mean square error is designed. Thus, it preserves boundary data and avoids too many virtual data in central area. Meanwhile, a strategy for eliminating abnormal samples is designed to reduce boundary deviation. For supporting the advantage of roundtrip, in-depth reasons for misdetection are analyzed from empirical risk and structural risk. Experiments on 30 benchmark imbalanced test sets show that fault detection rate increases after amount enhancement. Additionally, it is verified on blade cracking and bearing fault detection. Results show that F1 score increases from 0.485 to 0.51 and 0.725 to 0.775 for such two cases.
Depressive symptomatology from a network perspective: Differences in the experience of symptoms involved in the self-recognition of depression and the diagnosis process by social position
Authors: Alcalde Eugenia , Rouquette Alexandra , Wiernik Emmanuel , Rigal Laurent
Published: March 2024

Background:

While social disparities in depression are well-documented, the symptom experience across social positions remains less studied.

Aims:

This study examines the connections between depressive symptoms and self-recognizing a depressive episode, on the one hand, and clinical diagnosis, on the other hand, by three social position indicators.

Methods:

We analyzed baseline data from a population-based cohort of adults living in France, grouping participants by three indicators: education, financial difficulties, and occupation, and stratifying by sex. Utilizing a psychometric network approach, we estimated 24 networks. Nodes corresponded to the 20 CES-D items and 1 external variable, either ‘Limitations due to depression’ or ‘Clinical depression’. Comparisons between socially disadvantaged and advantaged groups across the three social indicators were made in terms of network structures, global strength, and edge weights involving symptoms and both external nodes.

Results:

The study included data from 201,952 participants. Individuals in lower social positions exhibited higher rates of depressive-related variables. Four depressive symptoms emerged as crucial, being linked both to ‘Clinical depression’ and ‘Limitations’ across all social positions. Socially disadvantaged groups had denser networks. Some of the tests comparing network structures according to social position were significant, suggesting differences in the symptom activation chains. Connections between each external node and ‘Felt depressed’ and ‘Could not get going’ were non-invariant in educational and financial-based networks.

Conclusions:

Findings highlight four depressive symptoms, likely to play a key role in the experience of depression across all social positions. Other insights from specific symptoms could be used for improving depression care among disadvantaged populations.
Mapping Risk Judgment and Risk Taking in Mountain Hiking: An Information Integration Approach
Authors: Fruchart Eric , Rulence-Pâques Patricia
Published: March 2024

Risk analysis is essential for promoting hiking-based tourism. Our objective in the present study was to map 395 mountain hikers’ positions on risk judgment and risk taking, according to how they integrated three antecedent factors of confidence (environment, team, and self). For integrating information, people can develop an additive rule whereby they apply the same weight to all information or use interaction rules (i.e., conjunctive or disjunctive), to give different weights to information. In the questionnaire our participants completed, there were eight scenarios that combined the three confidence antecedent factors as information cues. We applied cluster analysis, repeated-measures analyses of variance, chi-square tests, and bivariate correlation analyses to the questionnaire results to identify three participant risk positions. In the first risk position (cluster 1), participants used a disjunctive integration rule for both risk judgment and risk taking. In the second risk position (Clusters 2 and 4), they used an additive integration rule for risk judgment while they used a disjunctive integration rule for risk taking. In the third risk position (cluster 3), they used an additive integration rule for both risk judgment and risk taking. In each risk position, confidence in the three antecedent factors (environment, team, and self) negatively affected risk judgment and positively affected risk taking. We found the compositions of the clusters to be related to the participants’ sex, and we discuss various advantages of applying information integration for mountain hiking practitioners and promoters.
Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats
Authors: Nabirumbi Ritah , Onohuean Hope , Drago Kato Charles , Alagbonsi Abdullateef Isiaka , Adedeji Ahmed A.
Published: March 2024

Background: Pro-inflammatory cytokines are implicated in depression caused by both environmental- and alcohol-induced stress. The purpose of the study was to investigate the cytokine levels in serum and hippocampus following induction of depression-like behaviors (DLB) by either forced swimming test (FST) or ethanol-induced DLB (EID). We also investigated the effect of prior administration of antidepressant drug fluoxetine on cytokines in animals exposed to both models of DLB. Methods: Animals were pretreated with fluoxetine before inducing DLB, while DLB was induced in some animals using FST and ethanol in different groups of rats without fluoxetine pretreatment. The ELISA was used to detect changes in cytokine (IL-1β, IL-6, and TNF-α) levels in serum and hippocampus. Results: The mean levels of IL-1β and IL-6 measured in serum and hippocampus were significantly higher in FST and EID models when compared to the control group. The serum concentrations of IL-1β and IL-6 were significantly reduced in animals pre-treated with 5 mg/kg and 10 mg/kg of fluoxetine in both FST and EID models when compared to the untreated FST and EID groups respectively. Conclusions: In conclusion, both environment and alcohol can induce stress and DLB in rats with similar intensity, and their mechanisms of DLB induction involve activation of pro-inflammatory cytokines. Moreover, fluoxetine can prevent stress-induced inflammation in models of DLB.
Investigation of fabric tactile perception using the event-related potential method
Authors: Yuan Jie , Xu Changliang , Fang Jiahui , Lou Lin
Published: March 2024

The mechanism of the neuro-electrophysiological response of the human brain to skin tactile stimulation has always been an important research topic in the field of comfort perception of textile materials. In order to explore the characteristic neural potential components induced by various fabric tactile stimulation and their influence rules, event-related potential technology with ultra-high time resolution was introduced to monitor the somatosensory brain region under tactile stimulation of fabrics with different tactile properties, and the signal changes of related potentials were extracted and analyzed. The results showed that the amplitudes of N100 increased with the stiffness of the fabric, the amplitudes of P200 decreased with the smoothness of the fabric, and the amplitudes of P300 decreased with the smoothness and softness of the fabric. These results indicated that N100, P200, and P300 potentials could be used as neurophysiological response indexes of brain neurons to distinguish the subtle differences in fabric tactile properties. This finding not only laid a scientific theoretical basis for the brain perception mechanism of fabric tactile properties, but also provided a possibility for further quantification characterization of textile comfort perception.