bluuebunny/crossref_metadata_2025 huggingface dataset:
An analysis of the efficacy of botulinum neurotoxin type a in treating cervical dystonia
Authors: Zhou Xuan , Li Zhen-Fei , Guo Xuan-Zhu , Wei Qiao , Niu Ya-Nan , Li Meng , Xia Jia-Ning , Chen Li-Ping
Published: December 2023

BACKGROUND: The first-line treatment for cervical dystonia (CD) consists of repeated intramuscular injections of botulinum toxin (BoNT). However, the efficacy in some patients may be unsatisfactory and they may discontinue treatment. OBJECTIVE: To examine the factors associated with the maximum rate of remission in patients with CD after initial botulinum neurotoxin type A (or botulinum toxin type A abbreviated as BTX-A or BoNT-A) treatment. METHODS: Patients with CD who received BoNT-A injections were evaluated using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and the Tsui scale, with follow-up endpoints lasting until the start of the second injection. Patients who did not receive a second injection of BoNT-A were followed up for at least 5 months. The maximum remission rates were determined using the lowest Tsui and TWSTRS total scores during the follow-up period. We obtained basic information about these patients such as age, gender, duration of disease, presence of additional disease, types of torticollis, presence of anxiety, depression, tremors, single-photon emission computed tomography (SPECT) findings, injected dose, and so on from their medical records. RESULTS: A total of 70 patients with CD participated in this study, with males comprising 35.7% (25 individuals) with an average age of 45 ± 14 years old. The duration of disease was an independent risk factor for determining whether a complete remission has been attained using the Tsui scale (odds ratio [OR] = 0.978, 95% confidence interval [CI]: 0.959–0.997, P= 0.026). The optimal cut-off point for predicting patients who were unable to achieve complete remission based on duration of disease was 7.5 months (AUG = 0.711). Patients with CD with additional disease had greater difficulty achieving complete remission than those with CD alone based on TWSTRS assessments (P= 0.049). During the study, approximately 17% of all participants reported experiencing adverse reactions that lasted between 1 to 3 weeks before disappearing. CONCLUSION: BoNT is an effective and safe method for treating CD. The maximum remission rates of patients after their first injections are influenced by the duration of their disease. Thus, treatment using BoNT injections must be administered as soon as possible.
El procedimiento de tutela laboral y su aplicación a los funcionarios públicos de las Fuerzas Armadas tras la entrada en vigor de la Ley 21.280
Authors: Delgado Castro Jordi , Palomo Vélez Diego , Muñoz López Débora
Published: December 2023

Este trabajo trata sobre la aplicación del procedimiento de tutela laboral a los funcionarios públicos. Se tomará en específico el caso de las Fuerzas Armadas, puesto que se detectaron algunos casos en que estos fueron excluidos. Se confrontaron todas las causas de tutela desde la dictación de la Ley 21.280 y se concluye que, en efecto, este tipo de funcionario público está amparado por este instituto procesal.
New forms of regulation. The law under the test of the behavioral sciences
Authors: Taroni Marta
Published: December 2023

Thesis summary
Idiopathic Ventral Spinal Cord Herniation: An Illustrative Case and Literature Review
Authors:   Pars Advanced and Minimally Invasive Medical Manners Research Center, Rahimizadeh Abolfazl , Zafarshamspour Saber ,   Pars Advanced and Minimally Invasive Medical Manners Research Center, Williamson Walter ,   The Office of Clinical Research (OCR), Baylor College of Medicine, Houston, USA, Amirzadeh Mahan ,   Pars Advanced and Minimally Invasive Medical Manners Research Center, Rahimizadeh Shaghayegh ,   Pars Advanced and Minimally Invasive Medical Manners Research Center
Published: December 2023

Background and Importance: Idiopathic spinal cord herniation (ISCH), or spontaneous spinal cord herniation, is a rare but serious condition that can cause progressive myelopathy and irreversible neurological deficits if left untreated. The condition is marked by the gradual herniation of the spinal cord through a ventral defect in the dura, leading to compromised blood flow and neurological deficits. Common symptoms include Brown-Séquard syndrome or asymmetrical paraparesis. Treatment options typically focus on reducing the strangulated spinal cord and closing the dural defect with a synthetic patch. Case Presentation: We present the case of an adult woman with progressive asymmetrical weakness of the lower limbs compatible with spastic paraparesis. Thoracic magnetic resonance imaging (MRI) revealed characteristic features of ISCH at the T3-T4 level. Intraoperative neurophysiological monitoring was used during the surgical intervention, which involved a 3-level laminectomy, dura opening, excision of the dentate ligament, and reduction of the cord across the dural defect. The defect was then filled with an autogenous piece of muscle, followed by the closure of the defect with an artificial dural patch and dural closure. At the 6-month follow-up, the patient showed favorable improvement. Conclusion: Patients with slowly progressive paraparesis or Brown-Séquard syndrome should consider the possibility of ISCH as a potential cause, despite its rarity. In symptomatic cases, the preferred treatment option often involves reducing the incarcerated spinal cord followed by covering the dural defect.
ASSESSMENT OF FACTORS OF FOREIGN ECONOMIC RELATIONS OF UKRAINIAN BUSINESS
Authors:   Uzhhorod National University, Konar Mykola , Kushnir Nataliya ,   Uzhhorod National University
Published: December 2023

The article considers various factors of foreign economic relations and discloses several aspects, as well as a detailed analysis of statistical data, which in turn describe and substantiate: analysis of the impact of foreign economic factors on the Ukrainian economy and business environment; assessment of Ukraine's trade relations with other countries and regions; disclosure of the role of international investment in the development of Ukrainian business; analyze geopolitical risks and opportunities for Ukrainian business in the modern world; describe the study of the impact of international trade agreements and treaties on the development of Ukrainian business; conduct a comparative analysis of foreign economic challenges and opportunities for various sectors of the Ukrainian economy; describe the role of technological and innovative processes in Ukraine's foreign economic relations. The article describes foreign economic relations, which perform a variety of important functions in the economy and society, which allow businesses to exchange goods and services with others; which include direct investment and portfolio investment, help attract capital and technology from abroad to develop the domestic economy, and allow businesses to conduct financial transactions with other businesses, including currency exchange, loans, investments and other financial services. External cooperation and technology exchange are described as contributing to the development of the country's scientific and technical potential, increasing productivity and its competitiveness in the face of economic fluctuations in the domestic market, as they play a significant role in shaping the country's economic, political and socio-cultural landscape, contributing to its development and influencing its place in the global system in times of war. The article accurately reflects the importance of foreign economic relations for the country and its economic, political and socio-cultural development. Several key aspects are discussed in detail, such as foreign trade relations, which allow a country to exchange goods and services with other countries, which in turn helps to expand markets for domestic enterprises and increase the competitiveness of products, as well as foreign investment, which includes direct investment and portfolio investment, which in turn helps to attract capital and technology from abroad, which contributes to the development of the domestic economy and the creation of new jobs.
ANALYSIS OF INNOVATION AND INVESTMENT COOPERATION BETWEEN UKRAINE AND THE EU
Authors:   Uzhhorod National University, Mykhailiuk Odarka , Panov Alen ,   Uzhhorod National University
Published: December 2023

The present study critically delves into the intricate dynamics characterizing the bilateral relationship between Ukraine and the European Union, particularly within the realm of innovation and investment, spanning the expanse of the past decade. In this comprehensive exploration, the focal points of mutual interest and cooperation were meticulously unearthed, shedding light on the converging knowledge domains that have captured the attention of both parties. Drawing from a nuanced analysis, the study aptly elucidates the multifaceted factors that wield considerable influence over the successful implementation of collaborative endeavors at the international level. Moreover, the study proffers a series of judiciously crafted measures designed to mitigate the harmful impact of these identified factors. Notably, the conclusions drawn from this rigorous analysis find corroboration in the empirical evidence derived from global ratings and statistical data proffered by esteemed international organizations bolsters the credibility of the study's findings. In a pioneering stride, the study also presents a novel framework for appraising the efficacy of collaborative efforts in innovation and investment, predicated on the foundational tenets of sustainable development. This novel approach stands distinguished by its holistic consideration of the economic, environmental, and social ramifications inherent in the collaborative processes. Furthermore, the proposed evaluative framework offers a discerning vantage point for ascertaining the attractiveness of individual innovative projects for Ukraine and the European Union member states, thereby factoring in the intricate interplay of risks and uncertainties that often underlie such initiatives. Complementing these scholarly contributions, the study proffers a series of strategic recommendations tailored to enhance the efficacy of cooperative initiatives between Ukraine and the European Union in innovation and investment. Through its comprehensive scope and intelligent insights, this study significantly contributes to the ongoing discourse surrounding international collaboration in the dynamic domain of innovation and investment.
IMPACT OF PROTECTIONIST MEASURES ON THE TRADE WAR BETWEEN THE USA AND CHINA
Authors:   Uzhhorod National University, Rishko Mykhailo , Tsalan Myroslava ,   Uzhhorod National University
Published: December 2023

The article provides the analysis of the development of trade relations between the two largest economies in the world – the United States of America and China and the impact of protectionist measures on their course, and in particular on the period from 2018 – trade war and its consequences for both states. The main stages of the formation of trade between the USA and China and the role of the WTO in this process are studied. The positive and negative consequences of deepening trade relations between the United States and China are considered. Trade protection measures applied by both countries, in particular during the trade war between Washington and Beijing are taken into account. Important components of the study are statistical data on changes in trade volumes between states and trade volumes to which protectionist measures were applied, which makes it possible to assess the scale of the impact of the US-China trade conflict on the economies of both countries and on world trade. China's protectionist policy has always forced the US to turn to the WTO to settle dumping and subsidizing issues. Trump administration began to overprotect the American economy and this resulted in what the whole world still calls the biggest trade war in recent history. A particular concern about Beijing's "national leader" policy forced Washington to act. According to research by American experts, such a policy will create unrealistic competition in the market and establish China's monopoly in many areas of trade. The fact that the world economy is gradually recovering from the effects of COVID-19 adds relevance to this, as the reduction in domestic production has collapsed the volumes of US domestic production, threatening a wave of unemployment, the general decline of the United States economy and a potential recession. The issue of settling the dispute between the two giants of the economy falls on the WTO that cannot resolve the conflict and shuts down in attempts to find a solution. The ability of political leaders of both countries to step over national pride for the sake of global trade could be the way, but this way does not seem possible.
EURO-MEDITERRANEAN PARTNERSHIP: FORMATION AND DYNAMICS OF TRANSFORMATIONS IN THE CONTEXT OF SOCIO-POLITICAL, ENERGY AND ECONOMIC CHALLENGES
Authors:   Lviv Polytechnic National University, Ilnytska Uliana
Published: December 2023

The article is devoted to the current problem of the Euro-Mediterranean partnership in the context of sociopolitical, energy and economic challenges. The implementation of the Mediterranean vector of foreign policy by the European Union dates back to the 1950s. However, the policy of partnership was actualized only in the 21st century, which is determined by historical, geopolitical, economic, energy and socio-cultural factors. The article describes four stages of the formation and development of the Euro-Mediterranean partnership, defines the vectors, directions, features, forms and mechanisms of cooperation and cooperation. The dynamics of transformations of partnership and interaction strategies between the EU and the Mediterranean states are analyzed. Considerable attention is focused on the study of the impact of modern socio-political, economic, energy factors and historical events on the effectiveness of the Euro-Mediterranean partnership. Special attention is focused on the problems of illegal migration to the EU from the conflict zones of North Africa and the Middle East. The settlement of migration problems is considered as an actual vector and dimension of the Euro-Mediterranean partnership. In the context of modern regional and global challenges, the dynamics of the transformation of the Mediterranean vector of the European Union's foreign policy have been studied. The article indicates the positive dynamics of interstate interactions. The directions, features, vectors of the foreign policy strategies of the Euro-Mediterranean partnership (liberalization and intensification of trade; creation of a free trade zone between the EU and the countries of North Africa and the Middle East; implementation of investment projects; introduction of innovative technologies, standards; active cooperation and interaction in the energy sector) were comprehensively studied. formation of the regional energy security system). The priority directions of the partnership between the EU and the Mediterranean countries are the implementation of projects on the use of solar energy, the introduction of alternative energy sources, and the settlement of environmental and energy problems. In the context of modern security geopolitical challenges, the goals of the Euro-Mediterranean Partnership are to ensure peace and security; settlement of acute crises and conflicts; democratization of the political systems of the Mediterranean countries; fight against terrorism and illegal migration.
ФОРМУВАННЯ ВЕКТОРІВ АДАПТИВНОГО ІННОВАЦІЙНОГО РОЗВИТКУ ЕКОНОМІЧНИХ СУБ’ЄКТІВ ЗА УМОВ СТАЛОГО РОЗВИТКУ
Authors: Максименко Ж.В. , Командровська В.Є.
Published: December 2023

В статті визначено основні проблеми дестабілізації формування системи адаптивного інноваційного розвитку України. Авторами створено концептуальну модель реалізації адаптивного механізму інноваційного розвитку національної економіки. Визначено особливості модернізації фінансового механізму в контексті сталого розвитку. Проаналізовано інноваційний розвиток та адаптацію бізнес-структур в умовах невизначеного середовища. Описано пріоритетні напрямки формування системи адаптаційного інноваційного механізму: розвиток бізнес-технологій, інвестиційно-інноваційний розвиток, міжнародний бізнес. Зазначено короткострокові, середньострокові, довгострокові вектори адаптивного інноваційного розвитку національної економіки. Визначено вплив IT-сектору та хмарних технологій на досягнення цілей сталого розвитку економічних систем.
ПРОЄКТНИЙ ПІДХІД ДО РЕАЛІЗАЦІЇ ГЕОЗОННОГО МАРКЕТИНГУ
Authors: Деділова Тетяна , Кирчата Ірина , Согомонян Артуш
Published: December 2023

Геозонний маркетинг в сучасному світі є надзвичайно актуальним і важливим інструментом для бізнесу з різних галузей. За мету дослідження визначено розкриття особливостей реалізації геозонного маркетингу на засадах використання проєктного підходу у просуванні товарів та послуг. В роботі використано метод аналізу та синтезу, системний підхід. Доведено, що сутність проєктного підходу до реалізації геозонного маркетингу полягає в його орієнтації на створення та реалізацію цілеспрямованих проєктів для досягнення максимального впливу на цільову аудиторію в конкретних географічних локаціях. Розкрито взаємозв’язки геозонного маркетингу з елементами цільового проєктування. Запропоновано сфери застосування геозонного маркетингу за окремими напрямками з урахуванням світових тенденцій. Практична значущість дослідження полягає у можливості застосування таких сфер у проєктуванні стратегій просування товарів і послуг українськими компаніями.
ІНФОРМАЦІЙНА БЕЗПЕКА ПІДПРИЄМСТВА: КОНЦЕПТУАЛЬНІ ЗАСАДИ ЕФЕКТИВНОГО ЗАХИСТУ ІНФОРМАЦІЇ
Authors: Ясінська Алла
Published: December 2023

У статті розкрито проблематику щодо захисту інформації в системі управління підприємством. Обґрунтовано необхідність та доцільність застосування процедури інформаційної безпеки задля належного захисту та збереження її цілісності, корисності та актуальності. Досліджено сутність поняття комерційної таємниці та конфіденційної інформації на законодавчому рівнях. Визначено основні складові моделі інформаційної безпеки, зокрема джерела загроз (зовнішні та внутрішні), об’єкти загроз, а також у складі захисту інформації розподіл її за категоріями (публічна та з обмеженим доступом). Наведено характеристику видів захисту інформації на документальному та технічному рівнях. Досліджено різновиди методів та інструментів задля підвищення захисту, які доцільно застосовувати, їх взаємозв’язок з інформаційними джерелами та розпорядниками інформації.
ЕКОЛОГО-ЕКОНОМІЧНІ АСПЕКТИ ТРАНСФОРМАЦІЇ ЕНЕРГЕТИЧНОГО ЗАБЕЗПЕЧЕННЯ УКРАЇНИ В УМОВАХ ВІЙНИ ТА ПОВОЄННОГО ВІДНОВЛЕННЯ
Authors: Вовк Валерія , Красносельська Анастасія
Published: December 2023

У статті досліджено еколого-економічні аспекти трансформації енергетичного забезпечення України в умовах війни та повоєнного відновлення. Проаналізовано структуру загального постачання первинної енергії до країн ЄС-27 у 2021 р. Здійснено оцінку частки росії у попиті на природний газ країн ЄС-27 та Великобританії і встановлено, що близько половини спожитого природного газу у ЄС надходить із росії. Означено частку енергії з ВДЕ у країнах ЄС та зроблено висновок, що всі країни щороку збільшують використання чистої енергії. Також проаналізовано обсяги постачання енергії з ВДЕ в Україні у 2009-2020 рр. та простежено тенденцію до зростання цього показника протягом досліджуваного періоду. Визначено, що альтернативою для заміни природного газу є біогаз з подальшим доочищенням його до біометану, тому авторами запропоновано структурно-логічна схема виробництва біометану після доочищення біогазу. Встановлено, що основною перешкодою виробництва біометану в Україні є впорядкування регулятивних аспектів у частині визначення допустимої частки кисню у біометані для можливості подачі його у газорозподільну систему (для внутрішнього використання) та газотранспортну систему України для експорту за кордон (надходження валютної виручки та сприяння економічному зростанню країни).
Broad Range of Technologies Could Firm Up Wind and Solar Generation in Net Zero Carbon Dioxide Emission Electricity Systems
Authors: Wongel Alicia , Caldeira Ken
Published: December 2023

‘Firming’ technologies can be coupled to variable wind and solar generation to meet electricity demand reliably. Options that could participate in this firming role include dispatchable electricity generators, electricity storage technologies, atmospheric carbon dioxide removal, and demand management. In this study, we allow various firming technologies to participate in a stylized net zero CO2 emission electricity system reliant on wind and solar generation. By examining a series of least-cost systems in which the most valuable firming technologies are sequentially removed, we demonstrate that reliable wind-and-solar-reliant electricity systems do not depend on the feasibility of any particular firming technology.
PENDAMPINGAN KSM GELIS-IH MELALUI LITERASI SAMPAH DI JAMARAS KOTA BANDUNG
Authors: Hermawan Vera , Ardianti Dhini , Tapran Tini Martini
Published: December 2023

Program Kemitraan Masyarakat (PKM) literasi sampah melalui pemanfaatan media informasi di Jamaras Kelurahan Jatihandap Kecamatan Mandalajati, Kota Bandung, dilaksanakan per Januari 2022 selama 8 bulan. Mitra merupakan Kelompok Swadaya Masyarakat (KSM) di Jamaras RW 02, dengan populasi 1031 Jiwa. Pengelolaan sampah dibutuhkan melalui pendekatan komunikasi kepada KSM Gelis Ih (Gerakan Lingkungan Bersih). Permasalahan yang dihadapi di Jamaras adalah minimnya literasi tentang sampah dan juga sarana prasarana dalam pengelolaan sampah. Mitra terkendala dengan keterbatasan personil KSM sebagai motor penggerak pengelolaan sampah, sehingga diperlukan komunikasi persuasif, informasi dan edukasi untuk mengajak keterlibatan warga, dan peran dari pemangku kepentingan untuk mewujudkan kawasan bebas sampah. Solusi atas permasalahan ini melalui literasi sampah secara komprehensif, melalui pemanfaatan perangkat media informasi, kolaborasi antara pihak DLH, DKPP, GSSI, Ketapang.kita, perguruan tinggi dan stakeholder lainnya, hingga terorganisir dengan baik, dan pendampingan KSM Gelis Ih pengelolaan sampah untuk memberikan dampak positif bagi lingkungan dan pola hidup mitra. Metode pelaksanaan yang dilakukan melalui pendampingan dan menyiapkan perangkat media informasi untuk kebutuhan literasi. Pengintegrasian komunikasi top-down dan bottom-up untuk mengimplementasikan pengelolaan sampah. Hasil kegiatan PKM literasi sampah di Jamaras memiliki target mendukung kolaborasi dalam mewujudkan kawasan bebas sampah secara berkelanjutan. Kegiatan PKM FISIP Unpas yang dilakukan adalah social mapping dengan melakukan observasi dan wawancara dengan perangkat RW, Focus Group Discussion (FGD) bersama KSM Gelis Ih, dan pihak fasilitator ketapang.kita (GSSI), penyerahan bibit pohon hortikultura, liputan video pembuatan eco enzyme, serta fasilitasi signboard informasi jadwal pengangkutan dan pengelolaan sampah di Green House milik RW 02 Jamaras, atas inisiasi ketapang.kita.
PEMBERDAYAAN TENAGA KEPENDIDIKAN USB YPKP MENUJU PURNABAKTI PRODUKTIF
Authors: Setiawan Audita , Purwanto Heri , Ardiansyah Edi , Suryo Medianto , Fauzia Pertami Yuli Surya , Ammar Rafli , Maulidani Dinda
Published: December 2023

Kegiatan Pengabdian Masyarakat ini dilaksanakan di Universitas Sangga Buana (USB) YPKP untuk pada calon purna bakti tenaga kependidikan. Permasalahan utama yang dihadapi oleh para calon purna bakti adalah kurangnya persiapan yang baik dan matang bagi para calon purnabakti dalam menghadapi masa pensiun padahal usia pada saat mereka memasuki masa pensiun masih merupakan usia yang produktif. Para calon purnabakti akan mengalami momen penting dimana pada saat memasuki masa purnabakti, mereka akan mengalami perubahan peran dan status yang signifikan.  Seiring dengan berakhirnya masa kerja aktif, tenaga kependidikan perlu mempersiapkan diri secara baik untuk menghadapi perubahan tersebut. Persiapan yang matang menjadi kunci untuk menjalani masa purnabakti dengan sukses dan produktif. Kegiatan pengabdian ini dilaksanakan dengan program pemberdayaan wirausaha ikan hias. Pemahaman tentang wirausaha ikan hias dimulai dari keterampilan membudidayakan ikan hias di lahan pribadi yang dimiliki oleh para calon purnabakti sampai dengan bergabung dengan komunitas ikan hias untuk mempermudah proses penjualan ikan hias diharapkan memberikan peluang baru bagi tenaga kependidikan untuk mengembangkan minat dan keterampilan baru yang dapat digunakan sebagai sumber penghasilan.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Pelanggan Klinik Kecantikan Gaudentia Beauty Centre Bandung
Authors: Gulo Mintaniat , Hersusetiyati Hersusetiyati
Published: December 2023

Di era globalisasi kecantikan menjadi hal melekat bagi kaum wanita. Cantik sendiri didefinisikan sebagai hal yang utama. Hal inilah yang menyebabkan para pengusaha yang melihat peluang didalamnya, maka mendukung kemunculan klinik-klinik kecantikan menawarkan produk yang bervariasi dengan harga yang bervariasi juga, salah satunya Gaudentia Beauty Centre Bandung. Tujuan  penelitian ini adalah untuk mengetahui seberapa besar pengaruh kualitas pelayanan jasa terhadap kepuasan pelanggan Gaudentia Beauty Centre Bandung. Jenis Penelitian yang digunakan adalah penelitian kuantitatif. Berdasarkan hasil pengujian deskriptif dari 64 responden menunjukan bahwa kondisi Kepuasan Pelanggan terdapat nilai rata-rata sebesar 3,78 termasuk dalam kategori “Baik”. mean skor yang diperoleh 4,40 termasuk dalam kategori “Sangat Baik”, mean skor yang diperoleh 3,59 termasuk dalam kategori “Baik”. Dari 6 pernyataan dalam variabel Kepuasan Pelanggan terdapat 1 pernyataan dalam kategori “Sangat Baik” dan 5 lainnya termasuk dalam kategori “Baik”. Kesimpulan Berdasarkan hasil penelitian dari 64 pelanggan Klinik Kecantikan Gaudentia Beauty Center maka dapat disimpulkan, kualitas pelayanan di klinik tersebut kondisinya baik, namun perlu adanya peningkatan kualitas pelayanan agar pelanggan merasa lebih puas. kepuasan pelanggan Klinik Kecantikan Gaudentia Beauty Centre sebesar 51,9% sedangkan sisanya 48,1% dipengaruhi oleh faktor lain.
DIGITALISASI LAYANAN DAN FASILITAS PERPUSTAKAAN DALAM MEMPENGARUHI KEPUASAN PEMUSTAKA PADA PERPUSTAKAAN DAERAH KOTA SUKABUMI
Authors: Alhidayatullah Alhidayatullah
Published: December 2023

Digitalisasi layanan dan fasilitas perpustakaan merupakan faktor yang dapat meningkatkan kepuasan pemustaka. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh digitalisasi layanan dan fasilitas perpustakaan terhadap kepuasan pemustaka. Data penelitian ini adalah pemustaka pada Perpustakaan Daerah Kota Sukabumi dengan populasi sebanyak 1.120. Teknik pengambilan sampel dalam penelitian ini menggunakan web.raosoft.com sample size dengan tingkat error sebesar 5% sehingga didapatkan sampel sebanyak 287 responden. Menyebarkan kuesioner adalah metode pengumpulan data. Penelitian ini menggunakan analisis regresi linier berganda sebagai metode analisisnya. Hasil penelitian menunjukkan bahwa digitalisasi layanan dan fasilitas perpustakaan berpengaruh positif terhadap kepuasan pemustaka, dan pengaruhnya sebesar 60,9% sedangkan 39,1% dipengaruhi oleh variabel lain. Variabel yang memiliki pengaruh dominan yaitu fasilitas perpustakaan, dengan pengaruhnya sebesar 49,9%. Adapun kontribusi dalam penelitian ini adalah memperluas literature manajemen pemasaran terkait digitalisasi layanan dan fasilitas perpustakaan dalam konteks organisasi.
Reading, Writing, and Publishing an Obscene Canon: The Archival Logic of the Secret Museum, c. 1860–c. 1900
Authors: Bull Sarah
Published: December 2023

This article investigates how a loose network of Victorian book collectors, bibliographers, self-styled sexual scientists, and pornographers represented the obscene as a multifarious category of print, encompassing a generically, historically, and linguistically varied range of works about (or associated in the public imagination with) sex. By examining this elite network's reading, writing, collection, publishing, and advertising practices, this article demonstrates how diversely arrayed publications can, as a result of interacting historical, ideological, and commercial factors, become imaginatively linked, structuring the ways in which they are published, disseminated, and interpreted by their readers.
A Friend’s Reception: Dale Smith reviews Shake Hands, by Carl Thayler
Authors: Smith Dale
Published: December 2023

[para. 1]: "Our consideration of the world often forms through eyes of friends. These relations, carefully formed or abandoned with hazard, determine in us an awkward framework where emotion and intellect engage in fretful tug-of-war. That carefully exacted presence of self we bear to each other in friendship firms up or folds under the alien confrontation our relationships sustain. To form a deeper understanding of our nature we must enter with awkward certainty a recurring conflict of self-composition and presentation. Who we are and what we present ourselves to be are extended, challenged and confronted in the process of strengthening or abandoning friendships. Even those relations released of their animosity or enthusiasm provide a mundane meditation for our weaknesses and our strengths. We seek hints of ourselves in another’s confirmation, or denial. We embrace with love the sudden release of fire from the unknown that surprises us in another. A delicate mission, perhaps, to kindle friendship or extend love, but such is the structure of a psychology burdened by confrontation of animal hunger."

 
Energy performance of a geothermal heat pump system coupled to a greenhouse
Authors: Cepeda-Guerron Jonathan , Chiriboga Gonzalo , Carvajal Ghem
Published: December 2023

INTRODUCTION. The research focuses on designing and implementing a geothermal heat pump adapted to a 470 m2 greenhouse in the Andean region. OBJECTIVE. The goal is to maintain a temperature of 15 °C at night and 30 °C during the day, replacing conventional energy sources such as LPG and contributing to the sustainability and efficiency of food production in challenging climatic conditions. METHOD. We estimated the energy potential of solar and geothermal sources through precise measurements, which were compared to theoretical models. Subsequently, we calculated the appropriate size for the geothermal heat pump using the vapor compression cycle from the greenhouse's energy balance. Finally, we considered critical variables such as temperature and relative humidity to assess the energy efficiency of a geothermal heat pump. Prediction intervals were determined for the relevant variables to investigate values outside statistical control, and the construction of a heat map revealed heat transfer and thermal behavior in the greenhouse. RESULTS. The results demonstrated the impact of climatic conditions on the performance of the geothermal heat pump. Out of the 3169 analyzed data points, 7% fell outside the prediction intervals. CONCLUSIONS. This analysis underscores the critical influence of the environment on the energy efficiency of greenhouse cooling systems in the Andean region, suggesting the need for more efficient energy management strategies based on environmental conditions.
ПРОБЛЕМА НОРМАТИВНО-ПРАВОВОГО РЕГУЛЮВАННЯ ВІДПОВІДАЛЬНОСТІ ЗА ШКОДУ, ЗАВДАНУ КАЛІЦТВОМ
Authors: Лаговська Н. В. , Коваленко О. М.
Published: December 2023

У статті грунтовно проаналізовано особливості нормативно-правового регулювання відповідальності за шкоду, завдану каліцтвом.З’ясовано, що з метою формування порядку відшкодування збитків постраждалим Україна підписала у 2005 р. Європейську конвенцію про відшкодування збитку постраждалим від насильницьких злочинів, однак так і не ратифікувала її, що призвело до затягування процесу прийняття спеціального закону, який би урегулював відносини з надання державою компенсацій постраждалим від кримінальних правопорушень за тілесні ушкодження, а також фінансування їхнього лікування, відшкодування матеріальних та моральних витрат, витрат на поховання тощо.Звернено увагу, що хоч Кримінально-процесуальним кодексом України та Цивільним процесуальним кодексом України передбачено компенсацію шкоди, завданої постраждалому внаслідок кримінального правопорушення за рахунок державного бюджету, але відсутній унормований механізм відшкодування такої шкоди.

Встановлено, що боржником у зобов’язаннях із заподіяння шкоди є особа, на яку законом покладений обов’язок відшкодувати заподіяну потерпілому шкоду. Боржники поділяються на: а) осіб, які власними діями завдали шкоду потерпілому; осіб, на яких законом покладено обов’язок відшкодувати заподіяну шкоду.

Визначено, що основною причиною покладання обов’язку відшкодувати завдані збитки на інших осіб є необхідність захисту інтересів потерпілої особи, яка має отримати відшкодування заподіяної шкоди в будь-якому випадку, незалежно від того, чи може безпосередній заподіювач сам бути делінквентом і чи є у нього фінансова можливість відшкодувати заподіяну шкоду.

Виділено підстави, коли обов’язок відшкодувати завдані збитки покладається на інших осіб: неделіктоздатність заподіювача шкоди – зобов’язаними відшкодувати шкоду є батьки (усиновителі), опікуни (піклувальники) малолітніх, а іноді і неповнолітніх дітей, опікуни недієздатних фізичних осіб, повнолітні родичі неосудних осіб; діяльність заподіювача шкоди за вказівкою та на користь відповідальної особи – роботодавці за трудовими договорами, замовники за договорами.

Досліджено рішення Великої Палати Верховного Суду, яка постановила, що шкода, завдана потерпілому внаслідок кримінального правопорушення, компенсується йому за рахунок Державного бюджету України у випадках та порядку, передбачених законом.Встановлено, що держава несе майнову відповідальність перед потерпілими не за всі злочини, які залишилися нерозкритими, а лише у випадку, коли  шкода завдана фізичній особі, яка потерпіла від кримінального правопорушення. Шкода, завдана каліцтвом, іншим ушкодженням здоров’я або смертю внаслідок злочину, відшкодовується потерпілому або визначеним законодавством особам, державою, якщо не встановлено особу, яка вчинила злочин, або якщо вона є неплатоспроможною.Зауважено, що відсутність відповідного закону про порядок компенсації державою шкоди, завданої каліцтвом, не унеможливлює розгляд справи за позовом потерпілого, але значно утруднює цей прцес.
Least square-support vector machine based brain tumor classification system with multi model texture features
Authors: Khan Farhana , Gulzar Yonis , Ayoub Shahnawaz , Majid Muneer , Mir Mohammad Shuaib , Soomro Arjumand Bano
Published: December 2023

Radiologists confront formidable challenges when confronted with the intricate task of classifying brain tumors through the analysis of MRI images. Our forthcoming manuscript introduces an innovative and highly effective methodology that capitalizes on the capabilities of Least Squares Support Vector Machines (LS-SVM) in tandem with the rich insights drawn from Multi-Scale Morphological Texture Features (MMTF) extracted from T1-weighted MR images. Our methodology underwent meticulous evaluation on a substantial dataset encompassing 139 cases, consisting of 119 cases of aberrant tumors and 20 cases of normal brain images. The outcomes we achieved are nothing short of extraordinary. Our LS-SVM-based approach vastly outperforms competing classifiers, demonstrating its dominance with an exceptional accuracy rate of 98.97%. This represents a substantial 3.97% improvement over alternative methods, accompanied by a notable 2.48% enhancement in Sensitivity and a substantial 10% increase in Specificity. These results conclusively surpass the performance of traditional classifiers such as Support Vector Machines (SVM), Radial Basis Function (RBF), and Artificial Neural Networks (ANN) in terms of classification accuracy. The outstanding performance of our model in the realm of brain tumor diagnosis signifies a substantial leap forward in the field, holding the promise of delivering more precise and dependable tools for radiologists and healthcare professionals in their pivotal role of identifying and classifying brain tumors using MRI imaging techniques.
Hippo pathway in intestinal diseases: focusing on ferroptosis
Authors: Deng Hongwei , Jia Qiuting , Ming Xin , Sun Yuxin , Lu Yuxuan , Liu Li , Zhou Jun
Published: December 2023

The incidence of intestinal diseases, such as inflammatory bowel disease, gastric cancer, and colorectal cancer, has steadily increased over the past decades. The Hippo pathway is involved in cell proliferation, tissue and organ damage, energy metabolism, tumor formation, and other physiologic processes. Ferroptosis is a form of programmed cell death characterized by the accumulation of iron and lipid peroxides. The Hippo pathway and ferroptosis are associated with various intestinal diseases; however, the crosstalk between them is unclear. This review elaborates on the current research on the Hippo pathway and ferroptosis in the context of intestinal diseases. We summarized the connection between the Hippo pathway and ferroptosis to elucidate the underlying mechanism by which these pathways influence intestinal diseases. We speculate that a mutual regulatory mechanism exists between the Hippo pathway and ferroptosis and these two pathways interact in several ways to regulate intestinal diseases.
Salivary signatures of oral-brain communication in sleep bruxers
Authors: Deng Yuwei , Zhu Chenyuan , Jiang Ruixue , Yu Chunhua , Zhao Jun , Jiang Xinquan , Wen Jin
Published: December 2023

Introduction

Microbiota and their interaction with hosts have been of great interest in brain research in recent years. However, the role of oral microbiota in mental illness and the underlying mechanism of oral-brain communication remains elusive. Sleep bruxism (SB) is an oral parafunctional activity related to the nervous system and is considered a risk factor for harmful clinical consequences and severe systemic conditions. Exploring the connection between oral microbiota and sleep bruxism may deepen our understanding of the complex relationship between oral-brain axis and provide insights for treatment.

Methods

In this study, salivary samples were collected from 22 individuals with SB and 21 healthy controls, and metagenomics with metabolomics was performed. Nonparametric Wilcoxon test were applied for the statistical analysis between the two groups. Microbial dysbiosis and altered oral metabolites were found in the SB individuals.

Results

The characteristic metabolite N-acetylglucosamine (GlcNAc) (VIP=8.4823, P<0.05) was correlated to a statistically lower Streptococcus mitis level in SB individuals. Salivary IFN-g level and IFN-g/IL-4 ratio were detected with significant changes in a chip assay. Amino acid metabolism pathways were upregulated, and the pathway with the largest number of differentially expressed genes is related to amino-tRNA charging pathway, while the most significantly enriched pathway is related to arginine biosynthesis. Neurotransmitter-associated pathways with glutamatergic and GABAergic synapses and cardiovascular system-related pathways were enriched in the SB group.

Discussion

These results indicate a possible neuroimmune regulatory network of oral-brain communication in SB, which helps explain the mechanism of the oral microbiome with the host in sleep bruxers and provides a reference for early clinical and therapeutic intervention to improve the diagnosis and treatment of SB and similar diseases.
Application of invasive medical and pharmacological measures by German emergency paramedics
Authors: Koch Sebastian , Herwig Markus , Kahl Daniel
Published: December 2023

Introduction

German emergency paramedics are to avert serious damage to the patient's health in the event of acute illness or accidents. For this purpose, they have a variety of invasive medical and pharmacological measures at their disposal in addition to their three-year professional training. The aim of this thesis is to investigate the use of invasive medical and pharmacological measures by emergency paramedics in the German rescue service by means of instruments of professional scientific research. In doing so, the motivations of emergency paramedics to refrain from using these measures will be investigated for the first time.

Methods

For this study, rescue missions were analyzed during the period July 1, 2022, to June 30, 2023. The chosen method involved a quantitative document analysis of the deployment protocols to investigate the use of invasive and pharmacological measures by emergency paramedics and the reasons against their use.

Results

During the period, N = 10,102 (100%) rescue missions could be evaluated. Analysis of the data revealed that invasive medical measures were used by emergency paramedics in n = 1,211 (11.9%) missions and pharmacologic measures were used in n = 1,403 (13.8%) missions. Most frequently, emergency paramedics concluded that invasive medical measures were not required.

Discussion

In summary, the use of invasive medical measures is not a standard part of the emergency medical services mission. Rather, the focus is on diagnostics and transport of patients to an appropriate destination hospital. An adjustment of prehospital care structures based on evidence-based data and an update of the catalog of indications for emergency physician interventions would be elementary for this goal. Further studies of professional fields of action in emergency and rescue medicine are necessary in order to analyze and optimize care structures. This would not only allow conclusions to be drawn about the future education, further education and training of rescue service personnel, but also allow care structures to be adapted to the current state of science and the care needs of patients.
Molecular population genetics and phylogeographic studies of Ligia exotica and Ligia cinerascens in East Asia
Authors: Kim Gyeongmin , Kim Hyemin , Mun Sohyun , Choi Eun Hwa , Nguyen Anh D. , Hwang Ui Wook
Published: December 2023

Introduction

Sea slater, in the genusLigia, is widespread in rocky shore habitats, and the taxon is easily isolated due to its limited dispersal capacity. Therefore, mostLigiaspecies exhibit an allopatric distribution, butLigia exoticaandL. cinerascensexhibit an overlapping distribution distribution in East Asia. Previous studies on both species have confirmed the existence of highly divergent lineages based on16S rRNA.

Methods

In the present study, 282Ligiaindividuals were collected at ten, three, and three sites in South Korea, Japan, and Vietnam, respectively, and 41 haplotypes were observed based on16S rRNA.

Results and discussion

The results of phylogeny, phylogenetic network, and TCS network, Principal Coordinates Analysis, and four Molecular Species Delimitation Analyses revealed that six genetic lineages includingL. cinerascens, Lineages N and S ofL. exotica, Ligiasp. 1, sp.2 and sp.3 were present. The three genetic lineages, includingL. cinerascens,Lineage N ofL. exotica, and Lineage S ofL. exotica, were also identified in the phylogeny based on a nuclear gene of the sodium–potassium ATPase α-subunit (Nak). Phylogeographic analysis revealed thatL. cinerascensand Lineage N ofL. exoticawere distributed overlappingly in South Korea, Japan, and the northern region of China. Generally, the two lineages ofL. exoticawere distributed allopatrically, which was more evident along the coastline of mainland China than that of Japan. The results of time-calibrated phylogeny suggested that the speciation events ofLigiaspecies might be associated with Japanese mainland formation from Oligocene to Miocene (approximately 30-5 million years ago, Mya). The results of the present study provide insights that could facilitate the understanding of the evolutionary history ofLigia, tracking of geological processes, and evolutionary effects of palaeogeographical events at the population level.
CRISPR-Cas systems feature and targeting phages diversity in Lacticaseibacillus rhamnosus strains
Authors: Panahi Bahman , Dehganzad Behnaz , Nami Yousef
Published: December 2023

One of the most important adaptive immune systems in bacteria against phages is clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (CAS) genes. In this investigation, an approach based on genome mining was employed to characterize the CRISPR-Cas systems of Lacticaseibacillus rhamnosus strains. The analysis involved retrieving complete genome sequences of L. rhamnosus strains, and assessing the diversity, prevalence, and evolution of their CRISPR-Cas systems. Following this, an analysis of homology in spacer sequences from identified CRISPR arrays was carried out to investigate and characterize the range of target phages. The findings revealed that 106 strains possessed valid CRISPR-Cas structures (comprising CRISPR loci and Cas genes), constituting 45% of the examined L. rhamnosus strains. The diversity observed in the CRISPR-Cas systems indicated that all identified systems belonged to subtype II-A. Analyzing the homology of spacer sequences with phage and prophage genomes discovered that strains possessing only CRISPR-Cas subtype II targeted a broader spectrum of foreign phages. In summary, this study suggests that while there is not significant diversity among the CRISPR-Cas systems identified in L. rhamnosus strains, there exists notable variation in subtype II-A systems between L. rhamnosus and other lactobacilli. The diverse nature of these CRISPR-Cas systems underscores their natural activity and importance in adaptive immunity.
Masson pine pollen aqueous extract ameliorates cadmium-induced kidney damage in rats
Authors: Hu Zhiyong , Chen Sixin , Shi Tala , Dong Zhaoju , Cheng Mei , Li Ning , Zhao Huijuan , Zhu Haibo , Han Chunlei , Xu Lanlan
Published: December 2023

Introduction: Cadmium (Cd) is a hazardous environmental pollutant present in soil, water, and food. Accumulation of Cd in organisms can cause systematic injury and damage to the kidney. The Masson pine pollen aqueous extract (MPPAE) has attracted increasing attention due to its antioxidant activity and ability to enhance immunity.

Methods: In this study, we investigated the potential of MPPAE to protect against Cd-induced kidney damage in rats and the underlying mechanism. The transcriptome and metabolome of rats with Cd-induced kidney damage, following treatment with MPPAE, were explored.

Results: The concentrations of superoxide dismutase (SOD) and malondialdehyde (MDA) were both significantly altered after treatment with MPPAE. Furthermore, sequencing and analysis of the transcriptome and metabolome of rats with Cd-induced kidney damage, following treatment with MPPAE, revealed differential expression of numerous genes and metabolites compared with the untreated control rats. These differentially expressed genes (DEGs) included detoxification-related genes such as cytochrome P450 and the transporter. The differentially expressed metabolites (DEMs) included 4-hydroxybenzoic acid, L-ascorbate, and ciliatine. Conjoint transcriptome and metabolome analysis showed that several DEGs were correlated with DEMs.

Conclusion: These preliminary findings indicate the potential of MPPAE for the treatment of toxic metal poisoning.