bluuebunny/crossref_metadata_2025 huggingface dataset:
Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy
Authors: Feyaerts Dorien , Benner Marilen , van Cranenbroek Bram , van der Heijden Olivier W. H. , Joosten Irma , van der Molen Renate G.
Published: May 2017

Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on the transition of pre-pregnancy endometrial lymphocytes to a pregnancy state. Here, we immunophenotyped lymphocytes from endometrium (MMC), term decidua parietalis (DPMC), and PBMC for direct comparison. We found that the immune cell composition of MMC and DPMC clearly differ from each other, with less NK-cells, and more NKT-cells and T-cells in DPMC. An increased percentage of central memory and effector memory T-cells, and less naive T-cells in DPMC indicates that decidual T-cells are more experienced than endometrial T-cells. The increased percentage of CD4+CD25highCD127− Treg in DPMC, including differentiated Treg, is indicative of a more experienced and tolerogenic environment during pregnancy. The Th cell composition of both MMC and DPMC was different from PBMC, with a preference for Th1 over Th2 in the uterine environment. Between MMC and DPMC, percentages of Th cell subsets did not differ significantly. Our results suggest that already before pregnancy a tightly controlled Th1/Th2/Th17 balance is present. These findings create opportunities to further investigate the underlying immune mechanism of pregnancy complications using menstrual blood as a source for endometrial lymphocytes.
Bacterial protease uses distinct thermodynamic signatures for substrate recognition
Authors: Bezerra Gustavo Arruda , Ohara-Nemoto Yuko , Cornaciu Irina , Fedosyuk Sofiya , Hoffmann Guillaume , Round Adam , Márquez José A. , Nemoto Takayuki K. , Djinović-Carugo Kristina
Published: May 2017

Porphyromonas gingivalis and Porphyromonas endodontalis are important bacteria related to periodontitis, the most common chronic inflammatory disease in humans worldwide. Its comorbidity with systemic diseases, such as type 2 diabetes, oral cancers and cardiovascular diseases, continues to generate considerable interest. Surprisingly, these two microorganisms do not ferment carbohydrates; rather they use proteinaceous substrates as carbon and energy sources. However, the underlying biochemical mechanisms of their energy metabolism remain unknown. Here, we show that dipeptidyl peptidase 11 (DPP11), a central metabolic enzyme in these bacteria, undergoes a conformational change upon peptide binding to distinguish substrates from end products. It binds substrates through an entropy-driven process and end products in an enthalpy-driven fashion. We show that increase in protein conformational entropy is the main-driving force for substrate binding via the unfolding of specific regions of the enzyme (“entropy reservoirs”). The relationship between our structural and thermodynamics data yields a distinct model for protein-protein interactions where protein conformational entropy modulates the binding free-energy. Further, our findings provide a framework for the structure-based design of specific DPP11 inhibitors.
Correction: Corrigendum: A new gender-specific model for skin autofluorescence risk stratification
Authors: Ahmad Muhammad S. , Damanhouri Zoheir A. , Kimhofer Torben , Mosli Hala H. , Holmes Elaine
Published: May 2017

Scientific Reports 5: Article number: 10198; published online: 14 May 2015; updated: 31 May 2017. The Acknowledgements section in this Article is incomplete. “We would like to express our gratitude to all the participants of the study, management of both King Fahad Medical Research Center (KFMRC) and Arabian centers, and all the students who volunteered to help us in recruiting the subjects.
Molecular motions and free-energy landscape of serine proteinase K in relation to its cold-adaptation: a comparative molecular dynamics simulation study and the underlying mechanisms
Authors: Sang Peng , Du Xing , Yang Li-Quan , Meng Zhao-Hui , Liu Shu-Qun
Published: May 2017

The physicochemical bases for enzyme cold-adaptation remain elusive.
Ultra-low fouling methylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysates
Authors: Aubé Alexandra , Campbell Shirley , Schmitzer Andreea R. , Claing Audrey , Masson Jean-François
Published: May 2017

We synthesized novel ultra-low fouling ionic liquids and demonstrated their use with surface plasmon resonance (SPR) sensing for the analysis of HER2 in breast cancer cell lysates.
A 365 nm UV LED-excitable antenna ligand for switchable lanthanide luminescence
Authors: Lahdenperä Susanne , Wang Qi , Vainio Jiri , Soukka Tero
Published: May 2017

Synthesis and evaluation of a new 365 nm excitable antenna ligand for EuIII employed in switchable lanthanide luminescence.
Isotope dilution quantification of 5-hydroxymethyl-2-furaldehyde in beverages using vortex-assisted liquid–liquid microextraction coupled with ESI-HPLC-MS/MS
Authors: Feng Ting-Ting , Liang Xu , Wu Jian-Hai , Qin Lei , Tan Ming-Qian , Zhu Bei-Wei , Xu Xian-Bing
Published: May 2017

The vortex-assisted liquid–liquid microextraction (VALLME) coupled with HPLC-ESI-MS/MS method was a valid and rapid technique for isotope dilution quantification of HMF in beverages (carbonated drinks and soft drinks).
Keratin: dissolution, extraction and biomedical application
Authors: Shavandi Amin , Silva Tiago H. , Bekhit Adnan A. , Bekhit Alaa El-Din A.
Published: May 2017

A comprehensive review that compared the properties of keratin extracted by different extraction methods and investigated keratin suitability for biomedical applications.
Investigation of zinc ion storage of transition metal oxides, sulfides, and borides in zinc ion battery systems
Authors: Liu Wenbao , Hao Jianwu , Xu Chengjun , Mou Jian , Dong Liubing , Jiang Fuyi , Kang Zhuang , Wu Junlin , Jiang Baozheng , Kang Feiyu
Published: May 2017

MnS has the capability of storing zinc ions with high capacity and long cycle performance.
Incorporation studies of clickable ceramides in Jurkat cell plasma membranes
Authors: Walter T. , Schlegel J. , Burgert A. , Kurz A. , Seibel J. , Sauer M.
Published: May 2017

The acyl chain length and the azide position strongly influence the accessibility of the DBCO-dye, which was studied via TCEP quenching and anisotropy experiments.
Metal-free radical trifluoromethylation of β-nitroalkenes through visible-light photoredox catalysis
Authors: Midya Siba P. , Rana Jagannath , Abraham Thomas , Aswin Bhaskaran , Balaraman Ekambaram
Published: May 2017

First report an efficient catalytic conversion of nitroalkenes to 1-trifluoromethyalkenes under metal-free visible-light photoredox catalysis is disclosed.
Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction
Authors: Mahajan Suruchi , Chauhan Pankaj , Kaya Uğur , Deckers Kristina , Rissanen Kari , Enders Dieter
Published: May 2017

A highly enantioselective organocatalytic Strecker reaction of pyrazolone-derived ketimines with TMSCN has been developed providing an efficient entry to pyrazolone α-aminonitrile derivatives with a tetra-substituted stereocenter.
Photoactivatable europium luminescence turn-on by photo-oxygenation of β-diketone having pyrrole rings
Authors: Yuasa Junpei , Nakagawa Takafumi , Kita Yuki , Kaito Ayaka , Kawai Tsuyoshi
Published: May 2017

Bright europium(iii) red luminescence (PA-EuIII) turn-on is triggered by efficient photo-oxygenation of a β-diketone substrate having redox-active pyrrole moieties (LH2) in the presence of europium(iii) ions.
A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide
Authors: Hu Kuan , Sun Chengjie , Yang Dan , Wu Yujie , Shi Chuan , Chen Longjian , Liao Tao , Guo Jialin , Liu Yinghuan , Li Zigang
Published: May 2017

A chiral center of R absolute configuration at the γ-position to the C-terminal of a 10-membered tether could function to efficiently induce helicity of the backbone peptides.
Influence of the alkyl side-chain length on the ultrafast vibrational dynamics of 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide (CnmimNTf2) ionic liquids
Authors: Mohammad Kazemi Mehdi , Namboodiri Mahesh , Donfack Patrice , Materny Arnulf , Kerlé Daniela , Rathke Bernd , Kiefer Johannes
Published: May 2017

Time-resolved femtosecond spectroscopy reveals enhanced ultrafast vibrational energy transfer in imidazolium ionic liquids with long alkyl side chain.
Crucial role of titanium dioxide support in soot oxidation catalysis of manganese doped ceria
Authors: Mukherjee Deboshree , Venkataswamy Perala , Devaiah Damma , Rangaswamy Agolu , Reddy Benjaram M.
Published: May 2017

The influence of an anatase-TiO2support on the diesel soot oxidation catalytic activity of manganese doped ceria is investigated.
Enhancement of the antiproliferative activity of [RuCp(PPh3)2(dmoPTA-1κP)]+via its coordination to one {CoCl2} unit: synthesis, crystal structure and properties of [RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2N,N′-CoCl2](OTf)·0.25H2O
Authors: Mendoza Zenaida , Lorenzo-Luis Pablo , Scalambra Franco , Padrón José M. , Romerosa Antonio
Published: May 2017

Antiproliferative activity up to 354-fold for WiDr-colon cells than cisplatin.
A superhydrophilic “nanoglue” for stabilizing metal hydroxides onto carbon materials for high-energy and ultralong-life asymmetric supercapacitors
Authors: Li Shaofeng , Yu Chang , Yang Juan , Zhao Changtai , Zhang Mengdi , Huang Huawei , Liu Zhibin , Guo Wei , Qiu Jieshan
Published: May 2017

A superhydrophilic “nanoglue” strategy to tune and stabilize metal hydroxides onto carbon materials is presented for high-performance supercapacitors.
Quantitative surface-enhanced Raman spectroscopy of single bases in oligodeoxynucleotides
Authors: Dick S. , Bell S. E. J.
Published: May 2017

To address the question of whether the SERS signals of ss-DNA are simply combinations of the signals from the individual bases that comprise the sequence, SERS spectra of unmodified ss-DNA sequences were obtained using a hydroxylamine-reduced Ag colloid aggregated with MgSO4. Initially, synthetic oligodeoxynucleotides with systematic structural variations were used to investigate the effect of adding single nucleobases to the 3′ terminus of 10-mer and 20-mer sequences. It was found that the resulting SERS difference spectra could be used to identify the added nucleobases since they closely matched reference spectra of the same nucleobase. Investigation of the variation in intensity of an adenine probe which was moved along a test sequence showed there was a small end effect where nucleobases near the 3′ terminus gave slightly larger signals but the effect was minor (30%). More significantly, in a sample set comprising 25-mer sequences where A, T or G nucleobases were substituted either near the centres of the sequences or the 5′ or 3′ ends, the SERS difference spectra only matched the expected form in approximately half the cases tested. This variation appeared to be due to changes in secondary structure induced by altering the sequences since uncoiling the sequences in a thermal pre-treatment step gave difference spectra which in all cases matched the expected form. Multivariate analysis of the set of substitution data showed that 99% of the variance could be accounted for in a model with just three factors whose loadings matched the spectra of the A, T, and G nucleobases and which contained no positional information. This suggests that aside from the differences in secondary structure which can be eliminated by thermal pre-treatment, the SERS spectra of the 25-mers studied here are simply the sum of their component parts. Although this means that SERS provides very little information on the primary sequence it should be excellent for the detection of post-transcription modifications to DNA which can occur at multiple positions along a given sequence.
Valorisation of woody biomass by combining enzymatic saccharification and pyrolysis
Authors: Kalyani Dayanand C. , Fakin Tomaz , Horn Svein Jarle , Tschentscher Roman
Published: May 2017

This study shows, by a combination of enzymatic saccharification and pyrolysis, how integrated biochemical and thermochemical processes can be used to valorize woody biomass.
Lithium-ion batteries for sustainable energy storage: recent advances towards new cell configurations
Authors: Di Lecce Daniele , Verrelli Roberta , Hassoun Jusef
Published: May 2017

Sustainable energy storage may be achieved by using advanced lithium-ion battery configurations with high energy, low cost and environmental compatibility.
Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device
Authors: Nashimoto Yuji , Hayashi Tomoya , Kunita Itsuki , Nakamasu Akiko , Torisawa Yu-suke , Nakayama Masamune , Takigawa-Imamura Hisako , Kotera Hidetoshi , Nishiyama Koichi , Miura Takashi , Yokokawa Ryuji
Published: May 2017

Creating vascular networks in tissues is crucial for tissue engineering.
Analysis of organic and high dissolved salt content solutions using inductively coupled plasma optical emission spectrometry
Authors: Swearingen Kevin John , Omoto Trevor , Wall Nathalie
Published: May 2017

Quantification of analytes present in organic solvents or high salt content aqueous solutions using ICP-OES with minimal to no sample processing is desirable to improve analysis turnaround time and decrease sample cost.
Depth profiling of nanometer thin layers by laser desorption and laser postionization time-of-flight mass spectrometry
Authors: Yin Zhibin , Cheng Xiaoling , Liu Rong , Hang Wei , Huang Benli
Published: May 2017

A laser desorption and laser postionization time-of-flight mass spectrometer was employed for the depth profiling of nanometer thin-layers.
Recent advances in inductively coupled plasma optical emission spectrometry
Authors: Donati George L. , Amais Renata S. , Williams Charles B.
Published: May 2017

Review of recent developments in instrumentation, calibration strategies, and method development and applications of ICP OES for trace element analysis.
Deterministic trapping, encapsulation and retrieval of single-cells
Authors: Sauzade M. , Brouzes E.
Published: May 2017

Passive strategy for efficient true single-cell encapsulation.
A new class of chiral semiconductors: chiral-organic-molecule-incorporating organic–inorganic hybrid perovskites
Authors: Ahn Jihoon , Lee Eunsong , Tan Jeiwan , Yang Wooseok , Kim Bokyung , Moon Jooho
Published: May 2017

Chiral organic–inorganic hybrid perovskites exhibiting circular dichroism were prepared as a new class of chiral semiconductors.
Influence of iron metabolism on manganese transport and toxicity
Authors: Ye Qi , Park Jo Eun , Gugnani Kuljeet , Betharia Swati , Pino-Figueroa Alejandro , Kim Jonghan
Published: May 2017

The structural and chemical similarities between manganese (Mn) and iron (Fe) allow the two metals to interact with each other in biological systems.
Photovoltaic properties of novel thiophene- and selenophene-based conjugated low bandgap polymers: a comparative study
Authors: Lee Young Nam , Attri Pankaj , Kim Seong Su , Lee Sang Jun , Kim Jun Heon , Cho Tae Jong , Kim In Tae
Published: May 2017

We investigated the photovoltaic properties of two newly synthesized low bandgap conjugated polymers, thiophene-based P1 and selenophene-based P2.
Functionalized MWCNTs, an efficient reinforcement for the preparation of eugenol based high performance PBz/BMI/CNT nanocomposites exhibiting outstanding thermo-mechanical properties
Authors: Periyasamy Thirukumaran , Asrafali Shakila Parveen , Kim Seong-Cheol
Published: May 2017

This work contemplates the stabilization of eugenol-based benzoxazine networks with the addition of BMI and amine functionalized multiwalled carbon nanotubes.
Visual and fluorescence detection of pyrogallol based on a ratiometric fluorescence-enzyme system
Authors: Rao Hanbing , Dai Yongcheng , Ge Hongwei , Liu Xin , Chen Bingyao , Zou Ping , Wang Xianxiang , Wang Yanying
Published: May 2017

Schematic illustration of the synthesis of a CQDs@SiO2@CdTe QD nanohybrid as a ratiometric fluorescent probe for the detection of PG.
An ultrasensitive chemiluminescence aptasensor for indirect hemin detection based on aptamer recognition materials
Authors: Sun Yuanling , Wang Yanhui , Li Jianbo , Ding Chaofan , Lin Yanna , Sun Weiyan , Luo Chuannan
Published: May 2017

MGO@H-Atp@Co-PP polymers were successfully prepared and used to construct a MGO@H-Atp@Co-PP-CL aptasensor.
Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles
Authors: Dalzon Bastien , Aude-Garcia Catherine , Collin-Faure Véronique , Diemer Hélène , Béal David , Dussert Fanny , Fenel Daphna , Schoehn Guy , Cianférani Sarah , Carrière Marie , Rabilloud Thierry
Published: May 2017

The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms.
A cascade C–H functionalization/cyclization reaction of N-arylpyridin-2-amines with α,β-unsaturated aldehydes for the synthesis of dihydroquinolinone derivatives under rhodium catalysis
Authors: Wu Zi-Jun , Huang Kenneth L. , Huang Zhi-Zhen
Published: May 2017

A novel rhodium catalyzed cascade C–H functionalization/cyclization reaction of N-arylpyridin-2-amines with α,β-unsaturated aldehydes has been developed.
Correction: Giant vesicles from rehydrated crude mixtures containing unexpected mixtures of amphiphiles formed under plausibly prebiotic conditions
Authors: Fiore Michele , Madanamoothoo Warren , Berlioz-Barbier Alexandra , Maniti Ofelia , Girard-Egrot Agnès , Buchet René , Strazewski Peter
Published: May 2017

Correction for ‘Giant vesicles from rehydrated crude mixtures containing unexpected mixtures of amphiphiles formed under plausibly prebiotic conditions’ by Michele Fiore et al., Org. Biomol. Chem., 2017, 15, 4231–4240.
Fe-Porphyrin functionalized microporous organic nanotube networks and their application for the catalytic olefination of aldehydes and carbene insertion into N–H bonds
Authors: Zhou Minghong , Zhang Hui , Xiong Linfeng , He Zidong , Wang Tianqi , Xu Yang , Huang Kun
Published: May 2017

Fe-Porphyrin functionalized microporous organic nanotubes networks were synthesized by an in situ hyper-crosslinking reaction between bottlebrush copolymers and meso-tetraphenylporphyrin iron(iii) chloride.
ADMET polymerization of α,ω-unsaturated glycolipids: synthesis and physico-chemical properties of the resulting polymers
Authors: Hibert G. , Grau E. , Pintori D. , Lecommandoux S. , Cramail H.
Published: May 2017

Trehalose diesters exhibiting α,ω-unsaturation are glycolipids which can be easily polymerized by ADMET (acyclic diene metathesis) polymerization.
Multifunctional silica nanoparticles as a promising theranostic platform for biomedical applications
Authors: Xu Zhigang , Ma Xiaoqian , Gao Yong-E. , Hou Meili , Xue Peng , Li Chang Ming , Kang Yuejun
Published: May 2017

Recent advances in the use of nonporous silica nanoparticles as theranostic platforms for various biomedical applications, particularly in drug delivery, bioimaging and bio-adhesives.
In situ alternative switching between Ti4+and Ti3+driven by H2O2in TiO2nanostructures: mechanism of pseudo-Fenton reaction
Authors: Liu Zhihe , Wang Teng , Yu Xin , Geng Zhaoxin , Sang Yuanhua , Liu Hong
Published: May 2017

The pseudo-Fenton reaction driven byin situalternative switching between Ti4+and Ti3+driven by H2O2in TiO2nanostructures.
Exploring concentration, surface area and surface chemistry effects of colloidal aggregates on fat crystal networks
Authors: Chauhan Raamanand R. , Dullens Roel P. A. , Velikov Krassimir P. , Aarts Dirk G. A. L.
Published: May 2017

An investigation into the effects of concentration, surface area and surface chemistry of silica aggregates on a model fat-structured system.
Preparation and investigation of temperature-responsive calix[4]arene-based molecular gels
Authors: Cai Xiuqin , Xu Yunhua , Yang Rong , Yang Hui
Published: May 2017

Higher temperature enhances the strength and the toughness of the gel comprised of kerosene and a tetracholesteryl derivative based on calix[4]arene.
Renewable DNA seesaw logic circuits enabled by photoregulation of toehold-mediated strand displacement
Authors: Song Xin , Eshra Abeer , Dwyer Chris , Reif John
Published: May 2017

We propose a scalable design and verifications for photoregulated renewable DNA seesaw logic circuits, which can be repeatedly reset to reliably process new inputs. Synchronized control of complex DNA reaction networks could be achieved efficiently.
Metabolomic studies on the systemic responses of mice with oxidative stress induced by short-term oxidized tyrosine administration
Authors: Yang Yuhui , Yan Biao , Cheng Xiangrong , Ding Yinyi , Tian Xu , Shi Yonghui , Le Guowei
Published: May 2017

Oxidized tyrosine (O-Tyr) has attracted more interest in recent years because many researchers have discovered that it and its product (dityrosine) are associated with pathological conditions, especially various age-related disorders in biological systems.
Waste activated sludge (WAS) dewatering properties of an original hydrophobically modified polyacrylamide containing a cationic microblock structure
Authors: Zhou Yuhao , Zheng Huaili , Gao Baoyu , Gu Yingpeng , Li Xiang , Liu Bingzhi , Jiménez Andrea Mavarro
Published: May 2017

Chemical conditioning, as one of the core technologies used for the dewatering pretreatment of sludge, can efficiently improve the dewaterability of WAS and hence reduce the expense of the transportation and disposal of WAS.
A Ni-containing decaniobate incorporating organic ligands: synthesis, structure, and catalysis for allylic alcohol epoxidation
Authors: Li Li , Niu Yanjun , Dong Kaili , Ma Pengtao , Zhang Chao , Niu Jingyang , Wang Jingping
Published: May 2017

Na8{Ni[Ni(en)]2Nb10O32}·28H2O, representing the first example of trinuclear nickel-containing polyoxoniobate, has been synthesized. It was found to catalyze the epoxidation of 3-methyl-2-buten-1-ol with high conversion and selectivity.
The growth mechanism of calcareous deposits under various hydrostatic pressures during the cathodic protection of carbon steel in seawater
Authors: Li C. J. , Du M.
Published: May 2017

Ca2+ was substituted by Mg2+ in CaCO3 crystallization under high pressure resulting in a crystal transformation from aragonite to dolomite.
Investigation on a smart nanocarrier with a mesoporous magnetic core and thermo-responsive shell for co-delivery of doxorubicin and curcumin: a new approach towards combination therapy of cancer
Authors: Asghar Khushnuma , Qasim Mohd , Dharmapuri Gangappa , Das Dibakar
Published: May 2017

A novel and smart MIO-P(NIPAM-MAm) nanocomposite has been prepared for combinational delivery of Dox and Cur for cancer treatment.
The mechanical and thermodynamic properties of β-Si1−xC
Authors: Zhao Qiang , Zhang Zheng , Li Yang , Ouyang Xiaoping
Published: May 2017

We report the enthalpy (a), free energy (b), entropy (c) and heat capacity (d) of β-Si1–xC.
C-Glycosylated cinnamoylfuran derivatives as novel anti-cancer agents
Authors: Dutta Ananya , Dhara Debashis , Parida Pravat Kumar , Si Anshupriya , Yesuvadian Ravichandran , Jana Kuladip , Misra Anup Kumar
Published: May 2017

Synthesis of C-glycosylated cinnamoylfuran derivatives and their cytotoxic effects on cancer cells (MCF-7 and HeLa) and normal cells is presented.
Detection of domestic detergent residues on porcelain tableware using laser induced breakdown spectroscopy
Authors: Zhao Xiande , Dong Daming , Li Yang , Zhao Chunjiang
Published: May 2017

Domestic detergents are widely used and the detection of detergent residues on tableware is closely related to people's health. Using LIBS to detect detergent rapidly has a promising potential.
Simple access toward 3-halo- and 3-nitro-pyrazolo[1,5-a]pyrimidines through a one-pot sequence
Authors: Castillo Juan-Carlos , Rosero Hernán-Alejandro , Portilla Jaime
Published: May 2017

Herein, a regioselective, time-efficient and one-pot route for the synthesis of diversely substituted 3-halo- and 3-nitropyrazolo[1,5-a]pyrimidines in good to excellent yields through a microwave-assisted process is provided.
Fabrication and properties of a superhydrophobic film on an electroless plated magnesium alloy
Authors: Yuan Jing , Wang Jihui , Zhang Kaili , Hu Wenbin
Published: May 2017

A superhydrophobic film with high stability, self-cleaning function and robust corrosion inhibition on a magnesium alloy.
Optical control of membrane tethering and interorganellar communication at nanoscales
Authors: He Lian , Jing Ji , Zhu Lei , Tan Peng , Ma Guolin , Zhang Qian , Nguyen Nhung T. , Wang Junfeng , Zhou Yubin , Huang Yun
Published: May 2017

A light-controllable membrane tether to control protein subcellular localization and manipulate interorganellar contact sites at nanoscales.
Emerging plasmonic nanostructures for controlling and enhancing photoluminescence
Authors: Park Jeong-Eun , Kim Jiyeon , Nam Jwa-Min
Published: May 2017

Here, we review recent advances and provide perspectives in photoluminescence modulation and enhancement with plasmonic nanostructures.
CdS/ZnS core–shell nanocrystal photosensitizers for visible to UV upconversion
Authors: Gray Victor , Xia Pan , Huang Zhiyuan , Moses Emily , Fast Alexander , Fishman Dmitry A. , Vullev Valentine I. , Abrahamsson Maria , Moth-Poulsen Kasper , Lee Tang Ming
Published: May 2017

Herein we report the first example of nanocrystal (NC) sensitized triplet–triplet annihilation based photon upconversion from the visible to ultraviolet (vis-to-UV).
Hydride oxidation from a titanium–aluminum bimetallic complex: insertion, thermal and electrochemical reactivity
Authors: Brown Alexandra C. , Altman Alison B. , Lohrey Trevor D. , Hohloch Stephan , Arnold John
Published: May 2017

We report the synthesis and reactivity of paramagnetic heterometallic complexes containing a Ti(iii)-μ-H-Al(iii) moiety.
Synthesis of nano-porous carbon and nitrogen doped carbon dots from an anionic MOF: a trace cobalt metal residue in carbon dots promotes electrocatalytic ORR activity
Authors: Bhattacharyya Sohini , Konkena Bharathi , Jayaramulu Kolleboyina , Schuhmann Wolfgang , Maji Tapas Kumar
Published: May 2017

Synthesis of nanoporous carbon (NPC-1) and N-doped C dots (NCD-1) has been reported from an anionic MOF. Co doping in NCD-1 enhances electrocatalytic ORR activity.
Molecular weight and uniformity define the mechanical performance of lignin-based carbon fiber
Authors: Li Qiang , Serem Wilson K. , Dai Wei , Yue Yuan , Naik Mandar T. , Xie Shangxian , Karki Pravat , Liu Li , Sue Hung-Jue , Liang Hong , Zhou Fujie , Yuan Joshua S.
Published: May 2017

Quality lignin-based carbon fiber with high mechanical performance has been made from enzyme–mediator and dialysis fractionated lignin. In particular, the elastic modulus of lignin-based carbon fiber showed good correlations with PDI.
On the energetics of bound charge-transfer states in organic photovoltaics
Authors: Zhang Jiangbin , Jakowetz Andreas C. , Li Guangru , Di Dawei , Menke S. Matthew , Rao Akshay , Friend Richard H. , Bakulin Artem A.
Published: May 2017

Using temperature-dependent optical-control spectroscopy, we show that the binding energy of localised charge-transfer state is about 90 meV in a range of organic photovoltaic systems.
From biomass with irregular structures to 1D carbon nanobelts: a stripping and cutting strategy to fabricate high performance supercapacitor materials
Authors: Ouyang Tian , Cheng Kui , Yang Fan , Zhou Limin , Zhu Kai , Ye Ke , Wang Guiling , Cao Dianxue
Published: May 2017

We report a “stripping and cutting” strategy to produce 1D carbon nanobelts from tofu with irregular structures through a molten salts assisted technique and a high capacitance performance is obtained.
Pen lithography for flexible microsupercapacitors with layer-by-layer assembled graphene flake/PEDOT nanocomposite electrodes
Authors: Lee Hee Uk , Kim Seung Wook
Published: May 2017

An energy device using an all solid-state microsupercapacitor (MSC) has to play the roles of both a current collector and an electrode material, as well as demonstrating properties of high charge storage, conductivity, and flexibility.
An extremely high power factor in Seebeck effects based on a new n-type copper-based organic/inorganic hybrid C6H4NH2CuBr2I film with metal-like conductivity
Authors: Liu Yuchun , Li Xiaolei , Wang Jinbin , Xu Ling , Hu Bin
Published: May 2017

An extremely high power factor for organic/inorganic hybrid C6H4NH2CuBr2I due to the coexisting entropy difference.
Smart hybridization of Sn2Nb2O7/SnO2@3D carbon nanocomposites with enhanced sodium storage performance through self-buffering effects
Authors: Zhai Pengbo , Qin Jian , Guo Lichao , Zhao Naiqin , Shi Chunsheng , Liu En-Zuo , He Fang , Ma Liying , Li Jiajun , He Chunnian
Published: May 2017

Mulberry-like Sn2Nb2O7/SnO2nanoparticles homogeneously anchored on 3D carbon networks were prepared as an anode material for high-performance SIBs.
Interfacial modification of a lightweight carbon foam current collector for high-energy density Si/LCO lithium-ion batteries
Authors: Liu Zhengjiao , Bai Shuai , Liu Boli , Guo Pengqian , Lv Mingzhi , Liu Dequan , He Deyan
Published: May 2017

A thin Ti layer was utilized to modify the interface between carbon foam current collector and Si active layer.
Interface effect of mixed phase Pt/ZrO2 catalysts for HCHO oxidation at ambient temperature
Authors: Yang Xueqin , Yu Xiaolin , Lin Mengya , Ge Maofa , Zhao Yao , Wang Fuyi
Published: May 2017

High-efficiency Pt/ZrO2 catalysts with a mixed phase were successfully prepared. The catalysts exhibited high activity and their interfacial structure can change the reaction pathway.
Functionalization of bone implants with nanodiamond particles and angiopoietin-1 to improve vascularization and bone regeneration
Authors: Wu Xujun , Bruschi Michela , Waag Thilo , Schweeberg Sarah , Tian Yuan , Meinhardt Thomas , Stigler Robert , Larsson Karin , Funk Martin , Steinmüller-Nethl Doris , Rasse Michael , Krueger Anke
Published: May 2017

Biodegradable β-TCP implant materials functionalized with diamond nanoparticles are generated and characterized.
Spatially resolved photochemical coding of reversibly anchored cysteine-rich domains
Authors: Gegenhuber Thomas , Abt Doris , Welle Alexander , Özbek Suat , Goldmann Anja S. , Barner-Kowollik Christopher
Published: May 2017

We present a novel methodology to create rewritable surfaces using cysteine-rich domains via a combination of photolithography and reversible peptide-driven disulfide formation.
Structure distribution and turbulence in self-consistently supernova-driven ISM of multiphase magnetized galactic discs
Authors: Iffrig Olivier , Hennebelle Patrick
Published: May 2017

Context. Galaxy evolution and star formation are two multi-scale problems tightly linked to each other.

Aims. We aim to describe simultaneously the large-scale evolution widely induced by the feedback processes and the details of the gas dynamics that controls the star formation process through gravitational collapse. This is a necessary step in understanding the interstellar cycle, which triggers galaxy evolution.

Methods. We performed a set of three-dimensional high-resolution numerical simulations of a turbulent, self-gravitating and magnetized interstellar medium within a 1 kpc stratified box with supernova feedback correlated with star-forming regions. In particular, we focussed on the role played by the magnetic field and the feedback on the galactic vertical structure, the star formation rate (SFR) and the flow dynamics. For this purpose we have varied their respective intensities. We extracted properties of the dense clouds arising from the turbulent motions and compute power spectra of various quantities.

Results. Using a distribution of supernovae sufficiently correlated with the dense gas, we find that supernova explosions can reproduce the observed SFR, particularly if the magnetic field is on the order of a few μG. The vertical structure, which results from a dynamical and an energy equilibrium is well reproduced by a simple analytical model, which allows us to roughly estimate the efficiency of the supernovae in driving the turbulence in the disc to be rather low, of the order of 1.5%. Strong magnetic fields may help to increase this efficiency by a factor of between two and three. To characterize the flow we compute the power spectra of various quantities in 3D but also in 2D in order to account for the stratification of the galactic disc. We find that within our setup, the compressive modes tend to dominate in the equatorial plane, while at about one scale height above it, solenoidal modes become dominant. We measured the angle between the magnetic and velocity fields and we conclude that they tend to be well aligned particularly at high magnetization and lower feedback. Finally, the dense structures present scaling relations that are reminiscent of the observational ones. The virial parameter is typically larger than 10 and shows a large spread of masses below 1000 M⊙. For masses larger than 104M⊙, its value tends to a few.

Conclusions. Using a relatively simple scheme for the supernova feedback, which is self-consistently proportional to the SFR and spatially correlated to the star formation process, we reproduce a stratified galactic disc that presents reasonable scale height, SFR as well as a cloud distribution with characteristics close to the observed ones.
Sc(OTf)3-Catalyzed Aza-Friedel–Crafts Reaction of Electron-Rich Arenes with Isatin-Derived Ketimines: Access to 3-Amino-3-Aryl-2-Oxindoles
Authors: Gao Hongjie , Xu Xiangsheng , Xu Jianfeng
Published: May 2017

A Sc(OTf)3-catalyzed aza-Friedel–Crafts reaction of electron-rich arenes with isatin-derived ketimines is disclosed, providing biologically interesting 3-amino-3-aryl-2-oxindoles in moderate to good yields with broad substrate scope. This reaction can be easily scaled up, and the Boc protecting group could be readily removed under mild reaction conditions to afford the free amine.
Kinetic Resolution of 5-Substituted Oxazinones with Bifunctional Chiral Base/Squaramide Organocatalysts
Authors: Berkessel Albrecht , Eröksüz Serap , Neudörfl Jörg
Published: May 2017

5-Substituted oxazinones provide N-protected β2-amino acid esters upon alcoholytic ring opening. Thus far, this access to enantiopure β2-amino acids has been restricted to the use of enzymes (hydrolases) as catalysts for the kinetic resolution of racemic 5-substituted oxazinones, and branched alkyl or ortho-substituted aryl groups on the substrate oxazinone’s 5-position were typically not tolerated. We herein report that certain bifunctional chiral base/squaramide organocatalysts, in particular those derived from cis-1,2-diaminocyclohexane or 9-amino-9-epi-quinine, allow the first organocatalytic kinetic resolution of this ‘difficult’ class of oxazinone substrates, affording N-protected β2-amino acid esters with selectivity factors up to 43.
The Human Gut Microbiome in Liver Diseases
Authors: Davis Brian , Bajaj Jasmohan
Published: May 2017

Recent advances in culture-independent laboratory techniques and bioinformatics have contributed to enriched characterizations of the gut microbiota and microbiome in chronic liver diseases such as alcoholic liver disease, nonalcoholic fatty liver disease, primary sclerosing cholangitis, primary biliary cholangitis, and cirrhosis. In this review, the authors focus on studies characterizing and modulating the gut microbiota and microbiome in humans. The majority of studies that characterized microbiota involved a small number of patients using 16S ribosomal RNA genetic sequencing. Few studies applied whole-genome shotgun sequencing and metagenomics analyses. The majority of clinical trials on modulating the microbiome have focused on probiotics or antibiotics in small groups of patients with cirrhosis versus healthy controls. Several trials are underway using fecal microbial transplantation in alcoholic liver disease, nonalcoholic fatty liver disease, primary sclerosing cholangitis, and cirrhosis. Future research is needed on understanding the viral and fungal microbiome and developing user-friendly microbiome tools.
Speech-evoked Brainstem Auditory Responses and Auditory Processing Skills: A Correlation in Adults with Hearing Loss
Authors: Sanguebuche Taissane , Peixe Bruna , Bruno Rúbia , Biaggio Eliara , Garcia Michele
Published: May 2017

Introduction The auditory system consists of sensory structures and central connections. The evaluation of the auditory pathway at a central level can be performed through behavioral and electrophysiological tests, because they are complementary to each other and provide important information about comprehension.

Objective To correlate the findings of speech brainstem-evoked response audiometry with the behavioral tests Random Gap Detection Test and Masking Level Difference in adults with hearing loss.

Methods All patients were submitted to a basic audiological evaluation, to the aforementioned behavioral tests, and to an electrophysiological assessment, by means of click-evoked and speech-evoked brainstem response audiometry.

Results There were no statistically significant values among the electrophysiological test and the behavioral tests. However, there was a significant correlation between the V and A waves, as well as the D and F waves, of the speech-evoked brainstem response audiometry peaks. Such correlations are positive, indicating that the increase of a variable implies an increase in another and vice versa.

Conclusion It was possible to correlate the findings of the speech-evoked brainstem response audiometry with those of the behavioral tests Random Gap Detection and Masking Level Difference. However, there was no statistically significant correlation between them. This shows that the electrophysiological evaluation does not depend uniquely on the behavioral skills of temporal resolution and selective attention.
Diagnostik und Behandlung der schwangerschaftsassoziierten Thromboembolie – aktuelle Empfehlungen
Authors: Linnemann Birgit
Published: May 2017

Was ist neu?

Diagnostik in der Schwangerschaft Studien belegen den hohen Stellenwert der Kompressionssonografie der Beinvenen plus Duplexsonografie der Beckenvenen in der Diagnostik der Becken- und Beinvenenthrombose auch bei Schwangeren. Perfusionsszintigrafie und CT-Angiografie der Pulmonalarterien sind bei vergleichbarer fötaler Strahlenbelastung gleich aussagekräftig. Aufgrund der mütterlichen Strahlenbelastung favorisieren aktuelle Leitlinien bei fehlender struktureller Lungenerkrankung die Perfusionsszintigrafie als primäre Bildgebung. Es gibt keinen Grund, einer Schwangeren mit Lungenembolieverdacht eine notwendige radiologische Diagnosesicherung vorzuenthalten.

Antikoagulation in der Schwangerschaft Heparine bleiben Antikoagulans der 1. Wahl bei der Behandlung der venöses Thromboembolien (VTE) in der Schwangerschaft. Neue orale Antikoagulantien (NOAK) sind aufgrund ihrer geringen Molekülgröße plazentagängig und daher in der Schwangerschaft kontraindiziert.

Peripartales Vorgehen Zur Minimierung des postpartalen Blutungsrisikos vor der Geburt ist in den letzten Wochen vor der Geburt eine Aufteilung der NMH-Injektion auf 2 Tagesdosen sinnvoll. Bei der Entbindung ist eine interdisziplinäre Abstimmung wichtig. Postpartal kann eine NMH-Therapie fortgesetzt oder Warfarin eingesetzt werden (Kein Phenprocoumon, da es in die Muttermilch übergeht).
Akute Nierenschädigung (ANS) – Aktuelles zu (Früh)diagnostik und konservativer Therapie
Authors: Patschan Daniel , Müller Gerhard
Published: May 2017

Was ist neu?

Epidemiologie Die Häufigkeit der akuten Nierenschädigung (ANS) nimmt auf gesamteuropäischer Ebene zu. Dabei lässt sich weltweit keine signifikante Verbesserung der Prognose feststellen.

ANS-Diagnosekriterien und neue Indikatoren der ANS Trotz intensiver Bemühungen konnte bislang kein Marker identifiziert werden, welcher die Serumkreatininkonzentration als ANS-Indikator ersetzen könnte. Mutmaßlich ist eher mit der Etablierung eines diagnostisch-prognostischen Marker-Panels bei ANS zu rechnen.

Konservative Maßnahmen mit gesichertem Nutzen Die derzeit verfügbaren konservativen Therapieempfehlungen sind in den letzten Jahren kaum durch neue Maßnahmen ergänzt worden. Kristalloide Volumenpräparate sind kolloidalen Lösungen meist vorzuziehen. Zudem sind balancierte Elektrolytlösungen Chlorid-reichen Präparationen bei drohender/manifester ANS wahrscheinlich überlegen. Im Rahmen einer jeden Volumentherapie ist eine Hyperhydratation betroffener Patienten jedoch zu vermeiden.
Das Dunkelfeld intentional lebensbeendender Handlungen durch Ärzte und Pflegekräfte
Authors: Beine Karl , Schubert Torben
Published: May 2017

Einleitung Intentional lebensbeendende Handlungen (LH), darunter Tötung auf Verlangen und Tötung ohne explizite Willensäußerung, sind in Deutschland verboten und wenig erforscht. In einer Pilotstudie wurde das Dunkelfeld der Anwendung von LH durch Ärzte und Pflegekräfte im deutschen Gesundheitswesen untersucht.

Methoden Alle 2015 in Deutschland eingetragenen Kliniken und Altenheime (n = 13 393) wurden per Post oder E-mail angeschrieben. Ärztliche und pflegerische Mitarbeiter wurden um Bearbeitung des anonymen Online-Fragebogens oder der mitgesandten identischen Paper-Pencil-Version gebeten. 4629 Personen beantworteten Fragen zu LH am eigenen Arbeitsplatz, Bitten um aktive Sterbehilfe und selbst durchgeführte LH, darunter befanden sich Ärzte (n = 356), Krankenpfleger (n = 3121) und Altenpfleger (n = 1152) aus vorrangig stationären Arbeitsbereichen..

Ergebnisse 2,25 – 4,01 % (172 Personen) der Befragten gaben an, in den vergangenen 12 Monaten von LH am eigenen Arbeitsplatz gehört zu haben und 1,42 – 3,39 % (77 Personen) gaben an, LH jemals selbst durchgeführt zu haben. LH wurde häufiger von Männern, Ärzten und auf Intensivstationen durchgeführt. Mehr als ein Drittel der Personen, die LH durchgeführt hatten (38,10 – 41,67 %), waren nie darum gebeten worden.

Diskussion Unsere Erhebung lässt vermuten, dass neben legalen Formen der passiven und indirekten Sterbehilfe auch strafbare intentional lebensbeendende Handlungen durch Ärzte und Pflegekräfte in allen erhobenen Bereichen des Gesundheitssystems angewandt werden.
Management of an outsourced satellite phone development project: Sasken's experience
Authors: Sridhar V. , Vadivelu Selvaraj
Published: May 2017

Although Indian IT industry is well known for its software services business capabilities, product development still eludes the sector. This case illustrates the 5-year journey of Sasken Technologies – a mid-sized communication services company located in India to design, pre-build, test, integrate and certify a complex end-to-end satellite phone for a global satellite communication service provider. Knowing very well the inherent risks and uncertainties associated with such technology-intensive project, the CEO of Sasken signed the contract with the client with immense belief in his team to execute the project successfully. The case highlights the challenges encountered by the project managers of Sasken in acquiring the technology know-how, integrating hardware and software components, managing globally distributed teams, meeting regulatory requirements and mitigating unforeseen risks inherent in such off-shore outsourcing projects.
Note: A SMA wire actuated extremely long-lifetime release actuator using two ball-lock mechanisms
Authors: Huang Dawei , Yan Xiaojun , Zhang Xiaoyong , Bai Haibo , Wang Xian , Liu Ying
Published: May 2017

A shape memory alloy (SMA)-wire actuated release actuator with an extremely long lifetime was designed and validated. To ensure the ability of repeated actuation, two stages of ball-lock mechanisms were adopted to reduce the load in the SMA wire. In addition, a length-increasing design of the SMA wire was employed. Validation tests, including function tests, vibration tests, shock tests, and thermal vacuum tests were conducted on prototypes. According to the test results, the actuator can release a maximum preload of 15 kN and has a lifetime of more than 693 cycles. Furthermore, the actuator can function well, even under severe thermal and vibration environments.
First principles centroid molecular dynamics simulation of hydride in nanoporous C12A7:H−
Authors: Ikeda Takashi
Published: May 2017

Hydrides in nanoporous [Ca24Al28O64]4+(H−)4 (C12A7:H−) were investigated via first principles centroid molecular dynamics (CMD). The quality of our CMD simulations was assessed by examining the temperature dependence of the distribution of hydrides in the cages constituting the C12A7 framework. The vibrational states of C12A7:H− were analyzed by using the trajectories of the centroids generated in our CMD simulations. We find that the rattling motions of H− and D− behave qualitatively differently, resulting in non-trivial isotope effects, which are suggested to be detectable by using infrared and Raman spectroscopy.
A scaling theory of the free-coating flow on a plate withdrawn from a pool
Authors: Orsini Gabriele , Tricoli Vincenzo
Published: May 2017

A theory of free coating of a Newtonian liquid on a plate is developed based on scaling analysis of the flow. The analysis addresses the flow in the apical portion of the meniscus, where the film is entrained, and also of the bulk liquid conveyed from pool depths up to the surface. Film thickness as well as the characteristic curvature of the meniscus is predicted as a function of the capillary number Ca and the non-dimensional parameter Po=μ(g∕ρσ3)1∕4. No term in the Navier-Stokes equations is arbitrarily neglected; thus, the theory is valid virtually for any Ca and Po. The theory entails two adjustable constants, determined by least-squares fitting with the experimental data of Kizito et al. [“Experimental free coating flows at high capillary and Reynolds number,” Exp. Fluids 27, 235 (1999)]. However, once determined, these constants are to be considered as “universal” for free-coating on a plate. Rich thickness-vs-Ca behavior as a function of Po is predicted with a steep ascent of thickness at a certain Ca threshold, which depends on Po. At diverging Ca, the film thickness scaled to d0=μUρg12 asymptotes to a finite value independent of Po, while in the small-Ca limit the classical Landau-Levich law is duly recovered. The theory provides full physical understanding of each aspect of this behavior, revealing the roles of capillary-, inertial-, and gravity forces in the various regimes. The theoretical predictions are in full qualitative and quantitative agreement with the whole set of experimental results of Kizito et al., spanning over three orders of magnitudes both of Ca and Po. A non-monotonous behavior of the characteristic meniscus curvature scaled to the reciprocal film thickness, with a growth followed by a drop as a function of Ca, is predicted, in qualitative accordance with earlier experimental observations and computational results.