bluuebunny/crossref_metadata_2025 huggingface dataset:
Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76
Authors: Wang Xiaoli , Li Han , Fu Guolong , Wang Yunfu , Du Shiming , Yu Long , Wei Youheng , Chen Shi
Published: March 2016

As a member of the testis-specific serine/threonine protein kinase (TSSK) family, Tssk4 is exclusively expressed in the testis and plays an essential role in male fertility. We previously reported that Tssk4 can associate with and phosphorylate Odf2, but the phosphorylation site is still unknown. Here we confirm that the C-terminal region (amino acids 214-638) of Odf2 is required for association with Tssk4. Furthermore, to identify the site at which Tssk4 phosphorylates Odf2, we generated several Odf2 point mutants (Ser/Thr/Lys to Ala) and identified serine 76 of Odf2 as one of the phosphorylation sites. In vivo, phosphorylated Odf2 was evaluated in mouse sperm using a specific phospho-Ser-76 Odf2 antibody and LC-MS/MS. These findings are the first to demonstrate the phosphorylation site in Odf2 by Tssk4, providing essential clues regarding the function of Tssk4 in regulating sperm motility and/or structure and thus male fertility.
Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel
Authors: Wu Shih-Ying , Chen Yun-Wen , Tsai Sheng-Feng , Wu Sheng-Nan , Shih Yao-Hsiang , Jiang-Shieh Ya-Fen , Yang Ting-Ting , Kuo Yu-Min
Published: March 2016

Microglial activation is implicated in the pathogenesis of Parkinson’s disease (PD). Although the etiology of PD remains unclear, age and male gender are known PD risk factors. By comparing microglia and dopaminergic (DA) neurons in the substantia nigra (SN) of male and female mice of different ages, we found that the degrees of microglial activation and DA neuron loss increased with age in both genders, but were more pronounced in males, as were peripheral lipopolysaccharide (LPS)-induced microglial activation and DA neuron loss. A bilateral ovariectomy (OVX) eliminated the female-associated protection against age- and LPS-induced microglial activation, which suggests that ovary hormones are involved in gender-specific responses. Treating female mice with 17β-estradiol supplements reduced the age-associated microglial activation in OVX mice. Moreover, pretreating mouse BV2 microglial cells with 17β-estradiol inhibited LPS-induced elevation of Toll-like receptor 4, phosphorylated p38 and TNF-α levels. We then examined the effect of 17β-estradiol on inward-rectifier K+ channel Kir2.1, a known regulator of microglial activation. We found that 17β-estradiol inhibited the Kir2.1 activity of BV2 cells by reducing the probability that the channel would be open. We conclude that age- and inflammation-associated microglial activation is attenuated by ovarian estrogen, because it inhibits Kir2.1.
Silicon moderated the K deficiency by improving the plant-water status in sorghum
Authors: Chen Daoqian , Cao Beibei , Wang Shiwen , Liu Peng , Deng Xiping , Yin Lina , Zhang Suiqi
Published: March 2016

Although silicon (Si) has been widely reported to alleviate plant nutrient deficiency, the underlying mechanism in potassium (K) deficiency is poorly understood. In this study, sorghum seedlings were treated with Si under a K deficiency condition for 15 days. Under control conditions, plant growth was not affected by Si application. The growth and water status were reduced by K-deficient stress, but Si application significantly alleviated these decreases. The leaf gas exchanges, whole-plant hydraulic conductance (Kplant) and root hydraulic conductance (Lpr) were reduced by K deficiency, but Si application moderated the K-deficiency-induced reductions, suggesting that Si alleviated the plant hydraulic conductance. In addition, 29% of Si-alleviated transpiration was eliminated by HgCl2 treatment, suggesting that aquaporin was not the primary cause for the reversal of plant hydraulic conductance. Moreover, the K+ concentration in xylem sap was significantly increased and the xylem sap osmotic potential was decreased by Si application, suggesting that the major cause of Si-induced improvement in hydraulic conductance could be ascribed to the enhanced xylem sap K+ concentration, which increases the osmotic gradient and xylem hydraulic conductance. The results of this study show that Si mediates K+ accumulation in xylem, which ultimately alleviates the plant-water status under the K-deficient condition.
The three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition
Authors: Lou Deshuai , Wang Bochu , Tan Jun , Zhu Liancai , Cen Xiaoxi , Ji Qingzhi , Wang Yue
Published: March 2016

7α-hydroxysteroid dehydrogenase (7α-HSDH) can catalyse the oxidation of C7 α-OH of the steroid nucleus in the bile acid metabolism. In the paper we determined the crystal structure of 7α-HSDH from Clostridium absonum (CA 7α-HSDH) complexed with taurochenodeoxycholic acid (TCDCA) and NADP+ by X-ray diffraction, which, as a tetramer, possesses the typical α/β folding pattern. The four subunits of an asymmetric unit lie in the fact that there are the stable hydrophobic interactions between Q-axis-related subunits. Significantly, we captured an active state of the NADP+, confirming that nicotinamide moiety of NADP+ act as electron carrier in the dehydrogenation. On the basis of crystal structure analysis, site-directed mutagenesis and MD simulation, furthermore, we find that the guanidinium of Arg38 can form the stable cation-π interaction with the adenine ring of NADP+ and the cation-π interaction and hydrogen bonds between Arg38 and NADP+ have a significant anchor effect on the cofactor binding to CA 7α-HSDH.
A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission
Authors: Yu Nam-Kyung , Kim Hyoung F. , Shim Jaehoon , Kim Somi , Kim Dae Won , Kwak Chuljung , Sim Su-Eon , Choi Jun-Hyeok , Ahn Seohee , Yoo Juyoun , Choi Sun-Lim , Jang Deok-Jin , Lim Chae-Seok , Lee Yong-Seok , Kang Chulhun , Choi Soo Young , Kaang Bong-Kiun
Published: March 2016

Cell-permeable proteins are emerging as unconventional regulators of signal transduction and providing a potential for therapeutic applications. However, only a few of them are identified and studied in detail. We identify a novel cell-permeable protein, mouse LLP homolog (mLLP), and uncover its roles in regulating neural development. We found that mLLP is strongly expressed in developing nervous system and that mLLP knockdown or overexpression during maturation of cultured neurons affected the neuronal growth and synaptic transmission. Interestingly, extracellular addition of mLLP protein enhanced dendritic arborization, demonstrating the non-cell-autonomous effect of mLLP. Moreover, mLLP interacts with CCCTC-binding factor (CTCF) as well as transcriptional machineries and modulates gene expression involved in neuronal growth. Together, these results illustrate the characteristics and roles of previously unknown cell-permeable protein mLLP in modulating neural development.
Multistable internal resonance in electroelastic crystals with nonlinearly coupled modes
Authors: Kirkendall Christopher R. , Kwon Jae W.
Published: March 2016

Nonlinear modal interactions have recently become the focus of intense research in micro- and nanoscale resonators for their use to improve oscillator performance and probe the frontiers of fundamental physics. However, our understanding of modal coupling is largely restricted to clamped-clamped beams and lacking in systems with both geometric and material nonlinearities. Here we report multistable energy transfer between internally resonant modes of an electroelastic crystal plate and use a mixed analytical-numerical approach to provide new insight into these complex interactions. Our results reveal a rich bifurcation structure marked by nested regions of multistability. Even the simple case of two coupled modes generates a host of topologically distinct dynamics over the parameter space, ranging from the usual Duffing bistability to complex multistable behaviour and quasiperiodic motion.
Continuous variable quantum optical simulation for time evolution of quantum harmonic oscillators
Authors: Deng Xiaowei , Hao Shuhong , Guo Hong , Xie Changde , Su Xiaolong
Published: March 2016

Quantum simulation enables one to mimic the evolution of other quantum systems using a controllable quantum system. Quantum harmonic oscillator (QHO) is one of the most important model systems in quantum physics. To observe the transient dynamics of a QHO with high oscillation frequency directly is difficult. We experimentally simulate the transient behaviors of QHO in an open system during time evolution with an optical mode and a logical operation system of continuous variable quantum computation. The time evolution of an atomic ensemble in the collective spontaneous emission is analytically simulated by mapping the atomic ensemble onto a QHO. The measured fidelity, which is used for quantifying the quality of the simulation, is higher than its classical limit. The presented simulation scheme provides a new tool for studying the dynamic behaviors of QHO.
Local control on precipitation in a fully coupled climate-hydrology model
Authors: Larsen Morten A. D. , Christensen Jens H. , Drews Martin , Butts Michael B. , Refsgaard Jens C.
Published: March 2016

The ability to simulate regional precipitation realistically by climate models is essential to understand and adapt to climate change. Due to the complexity of associated processes, particularly at unresolved temporal and spatial scales this continues to be a major challenge. As a result, climate simulations of precipitation often exhibit substantial biases that affect the reliability of future projections. Here we demonstrate how a regional climate model (RCM) coupled to a distributed hydrological catchment model that fully integrates water and energy fluxes between the subsurface, land surface, plant cover and the atmosphere, enables a realistic representation of local precipitation. Substantial improvements in simulated precipitation dynamics on seasonal and longer time scales is seen for a simulation period of six years and can be attributed to a more complete treatment of hydrological sub-surface processes including groundwater and moisture feedback. A high degree of local influence on the atmosphere suggests that coupled climate-hydrology models have a potential for improving climate projections and the results further indicate a diminished need for bias correction in climate-hydrology impact studies.
Integrated mRNA and miRNA expression profiling in blood reveals candidate biomarkers associated with endurance exercise in the horse
Authors: Mach Núria , Plancade Sandra , Pacholewska Alicja , Lecardonnel Jérôme , Rivière Julie , Moroldo Marco , Vaiman Anne , Morgenthaler Caroline , Beinat Marine , Nevot Alizée , Robert Céline , Barrey Eric
Published: March 2016

The adaptive response to extreme endurance exercise might involve transcriptional and translational regulation by microRNAs (miRNAs). Therefore, the objective of the present study was to perform an integrated analysis of the blood transcriptome and miRNome (using microarrays) in the horse before and after a 160 km endurance competition. A total of 2,453 differentially expressed genes and 167 differentially expressed microRNAs were identified when comparing pre- and post-ride samples. We used a hypergeometric test and its generalization to gain a better understanding of the biological functions regulated by the differentially expressed microRNA. In particular, 44 differentially expressed microRNAs putatively regulated a total of 351 depleted differentially expressed genes involved variously in glucose metabolism, fatty acid oxidation, mitochondrion biogenesis, and immune response pathways. In an independent validation set of animals, graphical Gaussian models confirmed that miR-21-5p, miR-181b-5p and miR-505-5p are candidate regulatory molecules for the adaptation to endurance exercise in the horse. To the best of our knowledge, the present study is the first to provide a comprehensive, integrated overview of the microRNA-mRNA co-regulation networks that may have a key role in controlling post-transcriptomic regulation during endurance exercise.
Atomic structures of a liquid-phase bonded metal/nitride heterointerface
Authors: Kumamoto Akihito , Shibata Naoya , Nayuki Kei-ichiro , Tohei Tetsuya , Terasaki Nobuyuki , Nagatomo Yoshiyuki , Nagase Toshiyuki , Akiyama Kazuhiro , Kuromitsu Yoshirou , Ikuhara Yuichi
Published: March 2016

Liquid-phase bonding is a technologically important method to fabricate high-performance metal/ceramic heterostructures used for power electronic devices. However, the atomic-scale mechanisms of how these two dissimilar crystals specifically bond at the interfaces are still not well understood. Here we analyse the atomically-resolved structure of a liquid-phase bonded heterointerface between Al alloy and AlN single crystal using aberration corrected scanning transmission electron microscopy (STEM). In addition, energy-dispersive X-ray microanalysis, using dual silicon drift X-ray detectors in STEM, was performed to analyze the local chemistry of the interface. We find that a monolayer of MgO is spontaneously formed on the AlN substrate surface and that a polarity-inverted monolayer of AlN is grown on top of it. Thus, the Al alloy is bonded with the polarity-inverted AlN monolayer, creating a complex atomic-scale layered structure, facilitating the bonding between the two dissimilar crystals during liquid-phase bonding processes. Density-functional-theory calculations confirm that the bonding stability is strongly dependent on the polarity and stacking of AlN and MgO monolayers. Understanding the spontaneous formation of layered transition structures at the heterointerface will be key in fabricating very stable Al alloy/AlN heterointerface required for high reliability power electronic devices.
Colour-Difference Measurement Method for Evaluation of Quality of Electrolessly Deposited Copper on Polymer after Laser-Induced Selective Activation
Authors: Gedvilas Mindaugas , Ratautas Karolis , Kacar Elif , Stankevičienė Ina , Jagminienė Aldona , Norkus Eugenijus , Li Pira Nello , Račiukaitis Gediminas
Published: March 2016

In this work a novel colour-difference measurement method for the quality evaluation of copper deposited on a polymer is proposed. Laser-induced selective activation (LISA) was performed onto the surface of the polycarbonate/acrylonitrile butadiene styrene (PC/ABS) polymer by using nanosecond laser irradiation. The laser activated PC/ABS polymer was copper plated by using the electroless copper plating (ECP) procedure. The sheet resistance measured by using a four-point probe technique was found to decrease by the power law with the colour-difference of the sample images after LISA and ECP procedures. The percolation theory of the electrical conductivity of the insulator conductor mixture has been adopted in order to explain the experimental results. The new proposed method was used to determine an optimal set of the laser processing parameters for best plating conditions.
Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives
Authors: Song Gao-Peng , Hu De-Kun , Tian Hao , Li Ya-Sheng , Cao Yun-Shen , Jin Hong-Wei , Cui Zi-Ning
Published: March 2016

A pair of chemical isomeric structures of novel N-tert-butylphenyl thenoylhydrazide compounds I and II were designed and synthesized. Their structures were characterized by MS, IR, 1H NMR, elemental analysis and X-ray single crystal diffraction. The regioselectivity of the Meerwein arylation reaction and the electrophilic substitution reaction of N-tert-butyl hydrazine were studied by density functional theory (DFT) quantum chemical method. The larvicidal tests revealed that some compounds I had excellent larvicidal activity against Culex pipiens pallens. As the candidates of insect growth regulators (IGRs), the larval growth inhibition and regulation against Culex pipiens pallens were examined for some compounds, especially I1 and I7. Compounds I1 and I7 were further indicated as an ecdysteroid agonist by reporter gene assay on the Spodoptera frugiperda cell line (Sf9 cells). Finally, a molecular docking study of compound I7 was conducted, which was not only beneficial to understand the structure-activity relationship, but also useful for development of new IGRs for the control of mosquitos.
Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis
Authors: Bria E. , Pilotto S. , Simbolo M. , Fassan M. , de Manzoni G. , Carbognin L. , Sperduti I. , Brunelli M. , Cataldo I. , Tomezzoli A. , Mafficini A. , Turri G. , Karachaliou N. , Rosell R. , Tortora G. , Scarpa A.
Published: March 2016

In this study, we evaluated whether the presence of genetic alterations detected by next generation sequencing may define outcome in a prognostically-selected and histology-restricted population of resected gastric cancer (RGC). Intestinal type RGC samples from 34 patients, including 21 best and 13 worst prognostic performers, were studied. Mutations in 50 cancer-associated genes were evaluated. A significant difference between good and poor prognosis was found according to clinico-pathologic factors. The most commonly mutated genes in the whole population were PIK3CA (29.4%), KRAS (26.5%), TP53 (26.5%) MET (8.8%), SMAD4 (8.8%) and STK11 (8.8%). Multiple gene mutations were found in 14/21 (67%) patients with good prognosis, and 3/13 (23%) in the poor prognosis group. A single gene alteration was found in 5/21 (24%) good and 6/13 (46%) poor prognosis patients. No mutation was found in 2/21 (9.5%) and 4/13 (31%) of these groups, respectively. In the overall series, ß-catenin expression was the highest (82.4%), followed by E-Cadherin (76.5%) and FHIT (52.9%). The good prognosis group was characterized by a high mutation rate and microsatellite instability. Our proof-of-principle study demonstrates the feasibility of a molecular profiling approach with the aim to identify potentially druggable pathways and drive the development of customized therapies for RGC.
Growth of high quality and uniformity AlGaN/GaN heterostructures on Si substrates using a single AlGaN layer with low Al composition
Authors: Cheng Jianpeng , Yang Xuelin , Sang Ling , Guo Lei , Zhang Jie , Wang Jiaming , He Chenguang , Zhang Lisheng , Wang Maojun , Xu Fujun , Tang Ning , Qin Zhixin , Wang Xinqiang , Shen Bo
Published: March 2016

By employing a single AlGaN layer with low Al composition, high quality and uniformity AlGaN/GaN heterostructures have been successfully grown on Si substrates by metal-organic chemical vapor deposition (MOCVD). The heterostructures exhibit a high electron mobility of 2150 cm2/Vs with an electron density of 9.3 × 1012 cm−2. The sheet resistance is 313 ± 4 Ω/◻ with ±1.3% variation. The high uniformity is attributed to the reduced wafer bow resulting from the balance of the compressive stress induced and consumed during the growth and the thermal tensile stress induced during the cooling down process. By a combination of theoretical calculations and in situ wafer curvature measurements, we find that the compressive stress consumed by the dislocation relaxation (~1.2 GPa) is comparable to the value of the thermal tensile stress (~1.4 GPa) and we should pay more attention to it during growth of GaN on Si substrates. Our results demonstrate a promising approach to simplifying the growth processes of GaN-on-Si to reduce the wafer bow and lower the cost while maintaining high material quality.
Stability of titania nanotube arrays in aqueous environment and the related factors
Authors: Cao Can , Yan Jun , Zhang Yumei , Zhao Lingzhou
Published: March 2016

Titania nanotube arrays (NTAs) on titanium (Ti) fabricated by electrochemical anodization have attracted tremendous interest for diverse applications, of which most perform in aqueous environment or related to interaction with water. The NTAs are widely studied however the related factor of stability of NTAs when applied in such environment has rarely been concerned. We report that the annealed anatase NTAs are stable but the non-annealed amorphous NTAs are unstable to undergo specific structural change accompanied with a process of amorphous TiO2 dissolution and anatase TiO2 recrystallization. Quite unexpectedly, the non-annealed NTAs still show good stability without structural change in the cell culture media, possibly due to the presence of inorganics that may interfere with the TiO2 dissolution/redeposition process. The pH value of the aqueous environment is not a determinant factor for the structural change for non-annealed NTAs or not, while the temperature and the existence of F− can accelerate the structural change process. F− may play a very important role in the change process.
Detailed characterization of lysozyme (Lyz)–surfactant (SDDS) interaction and the structural transitions
Authors: Mandal Bithika , Ghosh Soumen , Moulik S. P.
Published: March 2016

Surfactant interaction can influence the protein structure manifesting molecular unfolding–folding.
Lipopolysaccharide of Klebsiella pneumoniae attenuates immunity of Caenorhabditis elegans and evades by altering its supramolecular structure
Authors: Kamaladevi Arumugam , Balamurugan Krishnaswamy
Published: March 2016

Given the prominence of lipopolysaccharide (LPS) in the pathogenesis of Gram-negative bacteria, investigations at the molecular level inin vivoconditions are in dire need to understand its role in provoking infection.
High-performance enzymatic membrane bioreactor based on a radial gradient of pores in a PSF membrane via facile enzyme immobilization
Authors: Zhu Xue-Yan , Chen Chen , Chen Peng-Cheng , Gao Qiao-Ling , Fang Fei , Li Jing , Huang Xiao-Jun
Published: March 2016

Hollow fiber polysulfone membranes with perfect radial gradient distributed pores were selected as substrates, and subsequently the enzyme-immobilization process was achieved by filtration and crosslinking, to finally construct an enhanced EMBR.
Multi-objective active machine learning rapidly improves structure–activity models and reveals new protein–protein interaction inhibitors
Authors: Reker D. , Schneider P. , Schneider G.
Published: March 2016

Active machine learning puts artificial intelligence in charge of a sequential, feedback-driven discovery process.
Iron–cobalt bimetal decorated carbon nanotubes as cost-effective cathode catalysts for Li–O2batteries
Authors: Kwak Won-Jin , Kang Tae-Geun , Sun Yang-Kook , Lee Yun Jung
Published: March 2016

FeCo bimetal decorated CNTs were synthesized as highly efficient and cost-effective non-noble metal catalysts for Li-O2batteries.
Silica-assisted incorporation of polydopamine into the framework of porous nanocarriers by a facile one-pot synthesis
Authors: Zheng Xianying , Chen Feng , Zhang Jixi , Cai Kaiyong
Published: March 2016

Mussel-inspired polydopamine (PDA), with its advanced bio-adhesive properties, has shown great potential in drug delivery based on host–guest interaction.
Micron-sized Fe–Cu–Si ternary composite anodes for high energy Li-ion batteries
Authors: Chae Sujong , Ko Minseong , Park Seungkyu , Kim Namhyung , Ma Jiyoung , Cho Jaephil
Published: March 2016

To develop a practicable Si-based anode for high-energy LIBs, a FeCuSi composite was developed by properly building Si-metal alloys.
Preparation and characterisation of an57Fe enriched haemoglobin spike material for species-specific isotope dilution mass spectrometry
Authors: Brauckmann C. , Frank C. , Schulze D. , Kaiser P. , Stosch R. , Swart C.
Published: March 2016

A species-specific ID-ICP-MS method for intact haemoglobin was developed applying an57Fe enriched haemoglobin spike, which was prepared and characterised carefully.
Facile synthesis of well-defined ABC miktoarm star terpolymers bearing poly(ε-caprolactone), polystyrene and stereoregular helical poly(phenyl isocyanide) blocks
Authors: Liu Chunhua , Mi Yan-Xin , Wang Rong-Hua , Jiang Zhi-Qiang , Zhang Xiao-Yan , Liu Na , Yin Jun , Wu Zong-Quan
Published: March 2016

A novel method for the synthesis of ABC miktoarm star terpolymers bearing poly(ε-caprolactone), polystyrene and helical poly(phenyl isocyanide) blocks has been developed.
Electrochemical sensing of nitrite using a copper–titanium oxide composite derived from a hexanuclear complex
Authors: Ehsan Muhammad Ali , Naeem Rabia , McKee Vickie , Saeed Abbas Hakeem , Pandikumar Alagarsamy , Huang Nay Ming , Mazhar Muhammad
Published: March 2016

An electrochemical nitrite ions sensor electrode, CuO–2TiO2, has been developed using single molecular precursor [Cu2Ti4(O)2(OH)4(TF)8(THF)6]·THF in aerosol assisted chemical vapour deposition technique.
A new indicator to evaluate the pollution of iron and manganese
Authors: Zhang Xu , Yang Huanhuan , Cui Zhaojie
Published: March 2016

Iron and manganese leaching into water via precipitation can cause water pollution. We evaluate the contamination of iron and manganese through behavior response, finally to obtain an online monitoring method on heavy metal pollution in water.
Fabrication of a polyaniline/MoS2 nanocomposite using self-stabilized dispersion polymerization for supercapacitors with high energy density
Authors: Kim Minkyu , Kim Yun Ki , Kim Jihoo , Cho Sunghun , Lee Gyeongseop , Jang Jyongsik
Published: March 2016

A honeycomb-like structured polyaniline/MoS2 nanocomposite has been prepared by self-stabilized dispersion polymerization, which exhibits enhanced electrochemical performances with high electrical conductivity.
In silico study on baicalein and baicalin as inhibitors of dengue virus replication
Authors: Hassandarvish Pouya , Rothan Hussin A. , Rezaei Sahar , Yusof Rohana , Abubakar Sazaly , Zandi Keivan
Published: March 2016

The dengue virus (DENV) is an important human arbovirus that belongs to the Flaviviridae.
A high-performance bioanode based on a nitrogen-doped short tubular carbon loaded Au nanoparticle co-immobilized mediator and glucose oxidase for glucose/O2 biofuel cells
Authors: Wang Wenyang , Jiang Kanghua , Zhang Xiaohua , Chen Jinhua
Published: March 2016

A high-performance bioanode for glucose/O2 biofuel cells based on N-STCs loaded Au NPs co-immobilized mediator and GOD was successfully developed.
The corrosion behaviors of multilayer diamond-like carbon coatings: influence of deposition periods and corrosive medium
Authors: Cui Mingjun , Pu Jibin , Zhang Guangan , Wang Liping , Xue Qunji
Published: March 2016

Electrochemical measurements, salt spray test and immersion test were employed to investigate the influence of deposition periods and corrosive medium on the corrosion behaviors of silicon doped multilayer diamond-like carbon (DLC) coating.
Palladium-catalyzed incorporation of atmospheric CO2: efficient synthesis of functionalized oxazolidinones
Authors: García-Domínguez Patricia , Fehr Lorenz , Rusconi Giulia , Nevado Cristina
Published: March 2016

CO2 at atmospheric pressure is used in two Pd-catalyzed multicomponent reactions to produce functionalized 5-methylene-1,3-oxazolidin-2-ones from propargylamines and aryl halides.
Low temperature synthesized ultrathin γ-Fe2O3 nanosheets show similar adsorption behaviour for As(iii) and As(v)
Authors: Liu Rui , Liu Jing-Fu , Zhang Li-Qiang , Sun Jie-Fang , Jiang Gui-Bin
Published: March 2016

As synthesised graphene-like, superparamagnetic γ-Fe2O3 nanosheets show superior inorganic arsenic scavenging performance, demonstrating the feasibility of solving an environmental problem through material innovation, and the foreground of 2D materials in environmental improvement.
Predicting high thermoelectric performance of ABX ternary compounds NaMgX (X = P, Sb, As) with weak electron–phonon coupling and strong bonding anharmonicity
Authors: Hong A. J. , Gong J. J. , Li L. , Yan Z. B. , Ren Z. F. , Liu J.-M.
Published: March 2016

The ABX ternary compounds have a variety of attractive physical properties.
Site-specific recombinases: molecular machines for the Genetic Revolution
Authors: Olorunniji Femi J. , Rosser Susan J. , Stark W. Marshall
Published: March 2016

The fields of molecular genetics, biotechnology and synthetic biology are demanding ever more sophisticated molecular tools for programmed precise modification of cell genomic DNA and other DNA sequences. This review presents the current state of knowledge and development of one important group of DNA-modifying enzymes, the site-specific recombinases (SSRs). SSRs are Nature's ‘molecular machines’ for cut-and-paste editing of DNA molecules by inserting, deleting or inverting precisely defined DNA segments. We survey the SSRs that have been put to use, and the types of applications for which they are suitable. We also discuss problems associated with uses of SSRs, how these problems can be minimized, and how recombinases are being re-engineered for improved performance and novel applications.
Energy harvesting and information processing in two‐way multiplicative relay networks
Authors: Shah S.T. , Choi K.W. , Hasan S.F. , Chung M.Y.
Published: March 2016

An energy harvesting (EH) and information processing network based on two‐way multiplicative relay is proposed. In the proposed scheme, two nodes communicate with each other via an energy constrained multiplicative relay node. The relay node uses power splitting‐based relaying protocol for EH and information processing. The numerical results show that the proposed scheme outperforms the legacy amplify‐and‐forward EH relaying technique.
Blind recognition of BCH codes in faster‐than‐Nyquist signalling system
Authors: Wu Gang , Zhang Bangning , Guo Daoxing , Liang Xiaohu
Published: March 2016

Proposed is a blind recognition method for Bose–Chaudhuri–Hocquenghem (BCH) codes in the faster‐than‐Nyquist (FTN) signalling system which is based on the Galois field Fourier transform of the code polynomial. Considering the signal‐to‐noise ratio estimation in coloured noise, the proposed method can maximise the correct recognition probability of the roots of the generator polynomial by an appropriate decision criterion. Moreover, an optimal threshold of the decision criterion is deduced. Simulation results demonstrate that the proposed method can recognise the BCH codes efficiently in the FTN signalling system.
Micropower CMOS lock‐in amplifier for portable applications
Authors: Maya Hernández P.M. , Sanz Pascual M.T. , Calvo B.
Published: March 2016

A new fully integrated micropower CMOS analogue lock‐in amplifier (LIA) is presented. To achieve a compact architecture able to operate under low voltage with low‐power consumption, it is based on a current‐mode amplifier with embedded rectification within the transconductance stage. Post‐layout results for a 0.18 µm CMOS implementation show a dynamic reserve of 51.2 dB, a power consumption of 482 µW and an integration area of 0.03 mm2. The frequency operation ranges from 450 Hz to 1.1 MHz, whereas the gain is programmable from 39 to 59 dB, providing the LIA with flexibility to match a wide range of applications.
Improvement of dynamic losses in pulse CW characterisation of non‐linear RF devices
Authors: Farah S. , Ayari L. , El‐Akhdar K. , Neveux G. , Barataud D.
Published: March 2016

A time‐domain (TD) measurement system that improves dynamic losses for pulsed radiofrequency characterisation of non‐linear devices is presented. This system allows the measurement of voltage and current TD waveforms at very high sampling rate at both ports of the device under test. The fully calibrated system is used to accurately characterise transients in a 40 W GaN wideband high power amplifier under pulsed signal excitation.
Prediction of power handling in tunable, high‐Q, substrate‐integrated, evanescent‐mode cavity bandpass filters
Authors: Saeedi S. , Lee J. , Sigmarsson H.
Published: March 2016

A circuit‐electromagnetic (EM) co‐design approach to predict the power handling of tunable, high‐Q, substrate‐integrated waveguide (SIW) bandpass filters is presented. The prediction approach is directly applied to a heavily‐loaded evanescent‐mode cavity filter in bandpass domain. To demonstrate the validity of the design method for structures with severe aspect ratios, a 4% second‐order Butterworth, evanescent‐mode cavity SIW bandpass filter, with a continuous tuning range from 3.0 to 3.6 GHz is designed, fabricated, and tested. The filter handles 26.9 W of continuous‐wave power at 3.0 GHz as predicted.
Simple compensation for lateral misalignments in resonant inductive coupling links
Authors: Eteng A.A. , Rahim S.K.A. , Leow C.Y. , Chew B.W. , Vandenbosch G.A.E.
Published: March 2016

This Letter describes a simple compensation method to reduce the transfer efficiency variation in a resonant inductive coupling (RIC) wireless power transfer link subject to lateral misalignment. The technique is based on impedance matching an RIC link such that the link operates at either over‐coupling or critical coupling within the extents of lateral misalignment. Applying the method in a test scenario led to a reduction in the range of obtained transfer efficiency values, from 45% of peak value in a conventional arrangement, to 5%. The proposed method has a potential for application in the design of free‐positioning planar wireless chargers.
Calculation method of winding eddy‐current losses for high‐voltage direct current converter transformers
Authors: Liu Yaqing , Zhang Dandan , Li Zhenbiao , Huang Qinqing , Li Bin , Li Menghu , Liu Jian
Published: March 2016

In this paper, a correction method is introduced to make a more accurate calculation of winding eddy‐current losses of high‐voltage direct current (HVDC) converter transformer. The assumption that winding eddy‐current losses of HVDC converter transformers follow the frequency with the exponent 2 proposed by IEC 61378‐2 Std. is thought to be inappropriate and the skin effect should be taken into consideration. The frequency characteristic of winding eddy‐current losses is proposed by analysing the distribution of magnetic flux in conductors, in which skin effect is taken into consideration. The correction method with a correction factor is then introduced to correct the assumption. To verify the validity of the correction method, a two‐dimension axisymmetric finite element analysis of a HVDC converter transformer is conducted. The geometrical complexity of windings and electrical connection are fully taken into account, it is shown that the correction method shows a significant advantage. Influence of different methods is revealed by applying the actual non‐sinusoidal load current and it is shown that the error of correction method is the least. At last, harmonic losses measurements are conducted on three coils to investigate the limits of the correction method.
Modified particle swarm optimisation‐based maximum power point tracking controller for single‐stage utility‐scale photovoltaic system with reactive power injection capability
Authors: Lal Vivek Nandan , Singh Sri Niwas
Published: March 2016

In this study, the control objectives such as maximum power point tracking (MPPT), synchronisation with grid and current control are realised for single‐stage utility‐scale photovoltaic (PV) system which is also capable of injecting the reactive power into the grid. For utility‐scale PV system, the single‐stage scheme is used for high efficiency and simple power converter topology. The proposed MPPT approach utilising a modified particle swarm optimisation method is interrelated with other control schemes. The MPP changes with variation in solar irradiation and temperature. Also, the PV power characteristic of large system is characterised by multiple peaks under partial shaded condition. The conventional methods such as hill climbing and incremental conductance methods do not work properly in these conditions. The proposed method is suitable to all conditions with reduced steady‐state fluctuations. The overall system is simulated in PSCAD and the effectiveness of the proposed method is tested on various conditions.
Ungleich­behandlung
Authors: Mühlnikel Ingrid
Published: March 2016

Einen richtig zufriedenen Eindruck machte der Hauptgeschäftsführer der Deutschen Krankenhausgesellschaft (DKG), Georg Baum, auf der Pressekonferenz des Gemeinsamen Bundesausschusses (GBA) nicht.
Unglückliche Formulierung
Authors: Lorenz Friederike
Published: March 2016

Mit dem Wettbewerbsstärkungsgesetz holt der Gesetzgeber wohl zum härtesten Schlag gegen die Pharmabranche aus. Künftig sollen nur noch die Medikamente bis zu einem Höchstpreis erstattet werden, die ihren Preis im Verhältnis zu ihrem Nutzen wert sind. Besonders umstritten dabei ist: Das IQWiG soll stets die Perspektive der gesetzlichen Krankenversicherung berücksichtigen.
Experiment auf der Seebühne
Authors: Glatzer Ulrich
Published: March 2016

Eins soll die Gesundheitspiazza auf keinen Fall werden: Ein weiterer Kongress, zu dem die immer selben Leute kommen, um einander die immer selben Geschichten zu erzählen. Die Initiatoren wollen vielmehr eine Plattform schaffen, die der Diskussion mit dem Blick nach Österreich und der Schweiz eine internationale Dimension verleiht.
Ein Chefarzt – zwei Standorte – zwei Länder
Authors: Dirks Claudia
Published: March 2016

Michael Jacobs ist Direktor der Klinik für Chirurgie und Gefäßchirurgie am Academisch Ziekenhuis Maastricht (AZM).
Gleichgesinnte lernen besser
Authors: Schiekiera Kirsten
Published: March 2016

Wer seine Mitarbeiter zur Schulung schickt, der sieht das als Investition – und die soll sich auszahlen. Die Erfahrung zeigt, dass Teilnehmer am meisten von Fortbildungen profitieren, wenn die Programme auf die Erfordernisse der Branche zugeschnitten sind.
Vergabe schützt vor Strafe nicht
Authors: Thalmayr Maria
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Politik der Nadelstiche
Authors: Mühlnikel Ingrid
Published: March 2016

Die Berliner Kassenärztliche Vereinigung stänkert gegen Hausarztverträge, bei denen sie nicht Vertragspartner ist. Das geschieht auf dem Rücken der Patienten – die sollen im Notfall eine Gebühr zahlen.
Voll befriedigend
Authors: Schiekira Kirsten
Published: March 2016

Diese Reform war überfällig. Nachdem die Beurteilung von Pflegeheimen zum Teil katas­trophale Ergebnisse zutage förderte, sollen künftig die Einrichtungen, für jedermann verständlich, nach dem Schulnotensystem bewertet werden. Dies ist nur eine der Neuerungen, die für einen stärkeren Qualitätswettbewerb unter den Heimen sorgen soll.
Ein fehlendes Puzzleteil
Authors: Dirks Claudia
Published: March 2016

Kaum hat das Jahr begonnen, schon geht es munter weiter im Reigen der Fusionen in der deutschen Gesundheits-IT-Branche. Den ersten Coup des Jahres 2008 meldet die Compugroup-Tochter Systema Deutschland GmbH. Sie hat mit der Übernahme der Fliegel-Data GmbH und der Herbert Dahm Datensysteme GmbH endlich den lang ersehnten Fuß in die Tür zum deutschen Kis-Markt bekommen.
Erfolgreicher Prototyp
Authors: Dirks Claudia
Published: March 2016

Medizinische Versorgungszentren (MVZ) sind in der deutschen Gesundheitslandschaft keine Seltenheit mehr. Nicht so oft kommt es dagegen vor, dass sie tatsächlich erfolgreich sind. Als Rarität können die bezeichnet werden, die erfolgreich und spezialisiert sind. Und dann gibt es noch das Endokrinologikum – ein erfolgreiches, spezialisiertes MVZ und bundesweit agierendes Franchiseunternehmen.
Auf dem Weg zum Alleskönner
Authors: Schmidt Hartmut
Published: March 2016

Die IT wird vom Hilfsmittel immer mehr zum wichtigen Werkzeug im Krankenhaus. Früher war sie nur zur Abrechnung da, seit einigen Jahren soll sie das papierlose Krankenhaus ermöglichen, und in Zukunft könnte sie eine Art Ärzteleitsystem sein.
Patschnass verwelken
Authors: Zehnder Adalbert
Published: March 2016

Es ist absurd: Da ertrinkt die Medizin geradezu in neuem Wissen. Zugleich verfällt das einmal erworbene aber gnadenlos schnell. Weil vor allem klinisches Wissen ein Wettbewerbsfaktor ist, müssen Krankenhausmitarbeiter ihr Know-how systematisch auffrischen. Organisieren müssen dies die Klinikmanager.
Sprich mit mir!
Authors: Schiekiera Kirsten
Published: March 2016

Patienten, die weder Deutsch noch Englisch sprechen, lassen viele Kliniken ins Stottern geraten. Das kann Ruf und Qualität beeinträchtigen, sogar juristische Folgen sind möglich. Ein hausinterner Dolmetschdienst mit fortgebildeten Kräften schafft Abhilfe.
Rechentricks
Authors: Mühlnikel Ingrid
Published: March 2016

Mit dem Mindestlohn wollen Arbeiterwohlfahrt und Volkssolidarität ausländische Konkurrenz auf dem Pflegemarkt vertreiben. Doch er könnte letztlich an der Sonderstellung der Kirchen im Tarifrecht scheitern.
Sozusagen verheiratet
Authors: Zehnder Adalbert
Published: March 2016

Der Kaiser ist tot – es lebe der Kaiser: Dieser zweigesichtige Spruch aus alten Zeiten illustriert anschaulich die sich wandelnde Bedeutung des Outsourcings im Gesundheitswesen. “Outsourcing ist out”, sagen die einen. Und die anderen prophezeien zugleich eine weiter wachsende Auslagerung von Dienstleistungen, die nicht zum Krankenhauskerngeschäft zählen. Was sich ändert, sind nicht die Geschäftsbeziehungen an sich. Dafür aber deren Form und Qualität.
Bevormundung geplant
Authors: Mühlnikel Ingrid
Published: March 2016

Das Gesetz zur Insolvenzfähigkeit der Kassen ließ lange auf sich warten. Jetzt kursiert ein Referentenentwurf, der es in sich hat. Die Entschuldung der Kassen gilt als Voraussetzung für den Start des Gesundheitsfonds.
Neue Holding in Hessen
Authors: Mau Jens
Published: March 2016

Der Hessische Landeswohlfahrtsverband (LWV) ist der Erste, der seine Kliniken und Heime in einer privatrechtlichen Holding bündelt. Mit elf Erwachsenen- und fünf Kinderkliniken ist der LWV Marktführer in der psychiatrischen Versorgung Hessens.
Kleine Starthilfe für die AOK
Authors: Mühlnikel Ingrid
Published: March 2016

Die großen Kassen, allen voran die Allgemeinen Ortskrankenkassen, haben es geschafft, den RSA zu ihren Gunsten zu verändern. Jetzt wird innerhalb des Kassenfinanzausgleichs künftig noch mehr Geld umverteilt: Volksleiden werden subventioniert, ihre Vermeidung dagegen wird nicht honoriert.
Luxus für Low-Care-Patienten
Authors: Gaede Kirsten
Published: March 2016

Ein Hotel für sogenannte Aufsteher und deren Aufenthalt aus der DRG-Pauschale bezahlen – davon haben schon viele Klinken geträumt. Im Klinikum Mannheim wird dieser Traum nun wahr. Die Krankenhausleitung ist überzeugt: Der Bedarf an Low-­Care-Pflege im Patientenhotel ist groß und wird in den nächsten Jahren sogar steigen.
Symbiotisch
Authors: Zehnder Adalbert
Published: March 2016

Im Gesundheitswesen ist es wie bei der Evolution: Nicht der Größte gewinnt den Kampf ums Dasein, sondern der Anpassungsfähigste. Partner, die sich verbünden und ergänzen, überstehen Umbrüche am besten. Eine Teilprivatisierung kommunaler Häuser kann solch eine Symbiose sein. Doch blind vertrauen darf man sich nicht.
Fels in der Brandung
Authors: Schmidt Hartmut
Published: March 2016

Nichts kann das Rhön-Klinikum erschüttern. Auch nicht die erheblichen Marktbelas­tungen in diesem Jahr, denen sehr viele Konkurrenten zum Opfer fallen werden. Die Zahlen für das 1. Quartal sehen gut aus, seine Prognose für 2008 konnte der Vorstand bestätigen. Trotzdem ist der Aktienkurs unverständlicherweise schwach.
Leistung lohnt sich nicht
Authors: Janning Martina
Published: March 2016

Gleich einer frischen Brise sollte das Leistungsentgelt die verstaubte Tarifwelt im öffentlichen Dienst durchpusten. Doch die Jahresprämien für 2007 richten sich nicht nach Einsatz und Können der Beschäftigten. Der aktuelle Tarifabschluss setzt das Leis­tungsentgelt in westdeutschen Krankenhäusern sogar bis 2009 außer Kraft.
Die Putzfrau in der Fallpauschale
Authors: Geißendorf Nicklas
Published: March 2016

Deckt mein Patient auch die Kosten für die Fläche, die seine medizinische Behandlung erfordert? Diese Frage treibt die Verantwortlichen in deutschen Kliniken immer wieder um. In welchem Rahmen tatsächlich eine Kostendeckung erreicht wird, hängt an der Berechnung der DRGs.
Porträt Joachim Bevelet
Authors: Stern Sara
Published: March 2016

Um den Job von Joachim Bovelet würden sich gegenwärtig nicht viele reißen. Die kommunale Berliner Klinikkette Vivantes ist trotz jahrelanger Sanierungsbemühungen nach dem zweiten Geschäftsführerwechsel innerhalb eines Jahres von ruhigem Fahrwasser weit entfernt.
Bye-Bye Blockbuster
Authors: Mau Jens
Published: March 2016

Jeder kennt die berühmte Kopfschmerztablette. Sie ist ein Blockbuster. Aber sie wirkt nicht bei jedem. Außerdem verträgt sie der eine besser als der andere. Das ist der Nachteil von Blockbustern. In Zukunft diagnostizieren Ärzte Krankheiten genauer – vor allem im Labor. Mithilfe von Gentests wird die Wahrscheinlichkeit einer künftigen Erkrankung prognostiziert. Solche Diagnosen beeinflussen auch die Strategien der Pharmaindustrie. Sie entwickelt weniger Blockbuster und mehr zielgerichtete Medikamente für kleinere Patientengruppen. Das sei “personalisierte Medizin”, sagen die Pharmahersteller.
Schutz vor bösem Erwachen
Authors: Gaede Kirsten
Published: March 2016

Zwei Sorten von Ängsten sind bei Patienten vor einer OP weit verbreitet: Nicht wieder aufzuwachen oder zu früh, sprich während des Eingriffs, aufzuwachen. Die unerwünschte Wachheit während der Operation, auch Awareness genannt, ist für den Patienten besonders dramatisch, wenn er sich nicht bewegen kann, aber Schmerzen empfindet und bei vollem Bewusstsein ist. Über dieses Phänomen gibt es sogar Filme wie den Thriller “Awake” von Joby Harold. Die Uniklinik Würzburg kann ihre Patienten jetzt beruhigen.
Der Machtkampf
Authors: Mühlnikel Ingrid
Published: March 2016

Das Institut für Qualität und Wirtschaftlichkeit soll neue innovative Arzneimittel und Verfahren einer Kosten-Nutzen-Bewertung unterziehen. Industrie und Institut streiten über die richtige Methodik. Für beide Seiten geht es um mehr als die korrekte Rechenweise.
Allrounder
Authors: Zehnder Adalbert
Published: March 2016

Baukonzerne mutieren zu Komplettdienstleistern für Großimmobilien. Durch Zukauf von Spezialunternehmen besorgen sie sich in ausgesuchten Branchen Kompetenz, Vertrauenswürdigkeit und Kunden. Im Visier haben sie auch den Krankenhaussektor, der wegen eines Generationswechsels in der Bausubstanz als besonders lukrativ gilt. Ein Beispiel für diese Geschäftsstrategie: Deutschlands Bauriese Nummer eins, Hochtief.
Teamgeist schützt vor Terror
Authors: Schiekiera Kirsten
Published: March 2016

Wenn Mitarbeiter ihren Vorgesetzten das Leben zur Hölle machen, gehen sie subtil vor. Trotzdem gibt es deutliche Mobbing-Warnhinweise. Schützen können sich Chefs, indem sie für klare Zuständigkeiten sorgen, ihre Entscheidungen transparent machen und Konflikten offensiv begegnen. Auch Seilschaften gehören zur Mobbing-Prävention.
Dicke Bretter bohren
Authors: Ekkernkamp Axel
Published: March 2016

Nach jahrelanger Diskussion hat die Bundesregierung die Finanznot der Krankenhäuser erkannt und rasche Hilfe versprochen.
Damit die Guten bleiben
Authors: Gaede Kirsten
Published: March 2016

Ausgebildete Anästhesie-Schwestern, OP-Pfleger und Intensiv-Schwestern – sie werden gebraucht wie nie zuvor und sind so rar wie lange nicht.
Dramatische Steigerung
Authors: Gaede Kirsten
Published: March 2016

Bundesweite Zahlen liegen zwar nicht vor. Doch die Dienstleistungsgewerkschaft Verdi beobachtet eine Zunahme von Überlastungsanzeigen. Der Medizin- und Pflegerechtsanwalt Volker Großkopf aus Köln bestätigt diesen Trend: „Überlastungsanzeigen nehmen drastisch zu, wir haben immer häufiger mit ihnen zu tun.“
Entschädigung wegen religionsbedingter Benachteiligung
Authors: Mau Jens
Published: March 2016

Tatbestand: Die muslimische Klägerin ist Deutsche türkischer Herkunft. Sie begehrt Entschädigung wegen religionsbedingter Benachteiligung in einem Personalauswahlverfahren. Die von dem Beklagten repräsentierte Diakonie versteht sich als unmittelbare Lebens- und Wesensäußerung der christlichen Kirche.
Sein durch Design
Authors: Schiekiera Kirsten
Published: March 2016

Mediziner legen auf die Gestaltung von Kommunikationsmitteln wie Websites und Visitenkarten nur wenig Wert. So verschenken sie Chancen. Wer sich ansprechend präsentiert, kann Geschäftspartner und Patienten beeindrucken. Aufdringliches und Avantgardistisches ist allerdings tabu.