bluuebunny/crossref_metadata_2025 huggingface dataset:
Symptoms of COVID-19 contagion in different social contexts in association to self-reported symptoms, mental health and study capacity in Swedish university students
Authors: Andersson Claes , Bendtsen Marcus , Molander Olof , Granlund Lilian , Topooco Naira , Engström Karin , Lindfors Petra , Berman Anne H.
Published: April 2022

Objective

The present study investigates if symptoms of COVID-19 contagion in different social contexts (cohabitants, family, acquaintances, and others) are associated with university students' own self-reported symptoms of COVID-19 contagion, mental health, and study capacity. This was investigated by a cross-sectional survey administrated in Sweden during the first wave of the COVID-19 pandemic, at the time when universities were locked down to limit viral spread and contagion.

Results

Mild to moderate symptoms of COVID-19 in cohabitants and family members were associated with student’s self-reported symptoms of contagion, while no associations could be seen in relation to mental health and study capacity. Symptoms of COVID-19 contagion in acquaintances and others were not associated with students’ self-reported symptoms, nor with their mental health and study capacity.

To conclude, during the initial lockdown of universities students’ self-reported symptoms of contagion were mainly associated with cohabitants and family members, while symptoms of contagion in different social contexts were not associated with mental health and study capacity. Findings suggest that lockdown of universities may have contributed to limiting infection pathways, while still allowing students to focus on their studies despite significant contagion among others known to the student.
Computational characterization and analysis of molecular sequence data of Elizabethkingia meningoseptica
Authors: Girdhar Neha , Kumari Nilima , Krishnamachari A.
Published: April 2022

Objective

Elizabethkingia meningoseptica is a multidrug resistance strain which primarily causes meningitis in neonates and immunocompromised patients. Being a nosocomial infection causing agent, less information is available in literature, specifically, about its genomic makeup and associated features. An attempt is made to study them through bioinformatics tools with respect to compositions, embedded periodicities, open reading frames, origin of replication, phylogeny, orthologous gene clusters analysis and pathways.

Results

Complete DNA and protein sequence pertaining to E. meningoseptica were thoroughly analyzed as part of the study. E. meningoseptica G4076 genome showed 7593 ORFs it is GC rich. Fourier based analysis showed the presence of typical three base periodicity at the genome level. Putative origin of replication has been identified. Phylogenetically, E. meningoseptica is relatively closer to E. anophelis compared to other Elizabethkingia species. A total of 2606 COGs were shared by all five Elizabethkingia species. Out of 3391 annotated proteins, we could identify 18 unique ones involved in metabolic pathway of E. meningoseptica and this can be an initiation point for drug designing and development. Our study is novel in the aspect in characterizing and analyzing the whole genome data of E. meningoseptica.
Metagenomic data for Halichondria panicea from Illumina and nanopore sequencing and preliminary genome assemblies for the sponge and two microbial symbionts
Authors: Strehlow Brian W. , Schuster Astrid , Francis Warren R. , Canfield Donald E.
Published: April 2022

Objectives

These data were collected to generate a novel reference metagenome for the sponge Halichondria panicea and its microbiome for subsequent differential expression analyses.

Data description

These data include raw sequences from four separate sequencing runs of the metagenome of a single individual of Halichondria panicea—one Illumina MiSeq (2 × 300 bp, paired-end) run and three Oxford Nanopore Technologies (ONT) long-read sequencing runs, generating 53.8 and 7.42 Gbp respectively. Comparing assemblies of Illumina, ONT and an Illumina-ONT hybrid revealed the hybrid to be the ‘best’ assembly, comprising 163 Mbp in 63,555 scaffolds (N50: 3084). This assembly, however, was still highly fragmented and only contained 52% of core metazoan genes (with 77.9% partial genes), so it was also not complete. However, this sponge is an emerging model species for field and laboratory work, and there is considerable interest in genomic sequencing of this species. Although the resultant assemblies from the data presented here are suboptimal, this data note can inform future studies by providing an estimated genome size and coverage requirements for future sequencing, sharing additional data to potentially improve other suboptimal assemblies of this species, and outlining potential limitations and pitfalls of the combined Illumina and ONT approach to novel genome sequencing.
Unspecified opioids among opioid overdoses in Oslo, Norway
Authors: Iqbal Zahra Zeineb , Nguyen Thanh Mai Thi , Brekke Mette , Vallersnes Odd Martin
Published: April 2022

Objective

Since 2017, an increasing number of opioid overdoses in Oslo, Norway, has been categorized as involving unspecified opioids, as noted in the patient records by the doctor treating the patient. In this study we compare the characteristics of overdoses involving unspecified opioids, long-acting opioids, and heroin. Data on patients presenting with opioid overdose was retrospectively collected from 1 October 2013 to 31 December 2019 at the Oslo Accident and Emergency Outpatient Clinic.

Results

Among 2381 included cases, 459 (19.3%) involved unspecified opioids, 134 (5.6%) long-acting opioids, and 1788 (75.1%) heroin. Overdoses involving unspecified opioids needed longer observation, median 5 h 29 min vs. 4 h 54 min (long-acting opioids) and 4 h 49 min (heroin) (p < 0.001), and had a lower Glasgow coma scale score, median 10 vs. 13 in both the other groups (p < 0.001). Naloxone was given in 23.3% of cases involving unspecified opioids, vs. 12.7% involving long-acting opioids and 30.2% involving heroin (p < 0.001). A larger proportion of patients were transferred to hospital care when unspecified or long-acting opioids were involved compared to heroin, 16.3% and 18.7% respectively vs. 10.1% (p < 0.001). Our results indicate that the category “unspecified opioids” encompasses a substantial proportion of opioids acting longer than heroin.
Bilateral emergency export reserve mechanism under climate change
Authors: Huang Kuang-Sheng
Published: April 2022

Consider that multilateral food aid and regional food security mechanisms may incompletely adapt to the challenges of climate change in future practice. This study proposes a framework of bilateral emergency export reserve mechanism to encourage both participating countries to jointly appoint a transnational agribusiness to manage emergency export reserves as a means of fulfilling its corporate social responsibility (CSR). This mechanism has the features of simplified negotiation, more transparent operating procedures, along with reciprocity in bilateral cooperation, which would provide grain importing countries with a higher degree of safeguarding food security.
Mapping the distributions of blood-sucking mites and mite-borne agents in China: a modeling study
Authors: Wang Tao , Meng Fanfei , Che Tianle , Chen Jinjin , Zhang Haiyang , Ji Yang , Fan Zhengwei , Zhao Guoping , Zhang Wenhui , Jiang Baogui , Xu Qiang , Lv Chenlong , Shi Taoxing , Ruan Shiman , Liu Lanzheng , Liu Wei , Yang Yang , Fang Liqun
Published: April 2022

Background

Emerging mite-borne pathogens and associated disease burdens in recent decades are raising serious public health concerns, yet their distributions and ecology remain under-investigated. We aim to describe the geographical distributions of blood-sucking mites and mite-borne agents and to assess their ecological niches in China.

Methods

We mapped 549 species of blood-sucking mites belonging to 100 genera at the county level and eight mite-associated agents detected from 36 species of blood-sucking mites in China during 1978–2020. Impacts of climatic and environmental factors on the ecology of 21 predominant vector mites and a leading pathogen, Orientia tsutsugamushi, were assessed using boosted regression tree (BRT) models, and model-predicted risks were mapped. We also estimated the model-predicted number, area and population size of affected counties for each of the 21 mite species in China.

Results

Laelaps echidninus is the leading mite species that potentially affects 744 million people, followed by La. jettmari (517 million) and Eulaelaps stabularis (452 million). Leptotrombidium scutellare is the mite species harboring the highest variety of mite-borne agents including four Rickettsia species and two viruses, followed by Eu. stabularis (2 agents), L. palpale (2) and La. echidninus (2). The top two agents that parasitize the largest number of mite species are O. tsutsugamushi (28 species) and hantavirus (8). Mammalian richness, annual mean temperature and precipitation of the driest quarter jointly determine the ecology of the mites, forming four clusters of major mite species with distinct geographic distributions. High-risk areas of O. tsutsugamushi are mainly distributed in southern and eastern coastal provinces where 71.5 million people live.

Conclusions

Ecological niches of major mite species and mite-borne pathogens are much more extensive than what have been observed, necessitating expansion of current filed surveillance.

Graphic Abstract
Evolutionary game analysis between employees and employers about working overtime from the perspective of information asymmetry
Authors: Dong Junjie , Yan Shumin
Published: April 2022

Background

Overtime is an international phenomenon, especially in some Chinese Internet technology companies, the 996 work regime is a common corporate atmosphere. This paper holds that overtime work is the result of a long-term dynamic game between employees and employers. In such a dynamic evolution process, employers and employees both cooperate and conflict, they will choose a strategy conducive to their own development through long-term learning and improvement.

Methods

Based on the evolutionary game theory and principal-agent theory, this paper constructs a $$2\times 2$$

2
×
2

evolutionary game matrix. The strategies of employees can be divided into voluntary overtime and involuntary overtime, while the strategies of employers can be divided into providing overtime pay and not providing overtime pay. The stability of the system is related to four parameters: resource consumption, information asymmetry coefficient, trust coefficient, and moral hazard coefficient.

Results

Through an in-depth study of the model and data simulation, the system has five equilibrium points, an ESS point, and a saddle point in any case. Accordingly, we put forward two theorems and three propositions, which are verified not only theoretically but also by data simulation. Besides, the strategies of the employees and the employers will evolve from the initial state to (Involuntarily, Not pay) or (Voluntarily, Pay) under different situations. This is closely related to the initial parameters of the evolutionary game model and the payment matrix.

Conclusions

By summarizing the influence of each parameter on the evolutionary path, we believe that fairness and information equivalence between employees and employers can effectively promote both parties to reach the Pareto optimal state. In other words, employees and employers need to communicate and share information promptly to ensure the unity of information acquired by each other and achieve a win–win situation. This paper contributes to providing theoretical guidance and practical enlightenment for organizations to manage employees' overtime behavior scientifically and improve their work psychology reasonably.
Intercultural competence outcomes of a STEM living–learning community
Authors: Starr Laura , Yngve Katherine , Jin Lan
Published: April 2022

Background

Living–learning communities and global or diversity learning experiences have been identified as educational practices which often have a “high impact” on student success, as well as providing interpersonal competencies that are greatly valued by employers. Even without a specific intercultural or diversity component, living–learning communities would seem to offer rich settings for the development of the ability to work effectively across cultural difference. Yet intercultural learning outcomes are rarely assessed outside the domain of study abroad or diversity training programs. The purpose of this study was to determine whether participation in a “global science” living–learning community can increase the intercultural competence of first year international and domestic students, as measured by a well-known quantitative instrument, the Intercultural Development Inventory (IDI).

Results

In the first 2 years of the study, the intercultural learning content focused primarily on ‘dealing effectively with difference’ and produced minimal mean gains in intercultural competence. Examination of qualitative data from these experiences (using a well-known rubric to frame the analysis) as well as a review of the literature around intercultural learning (principally in study abroad contexts) suggested that focusing on similarity and self-awareness, coupled with individualized feedback, was likely to be a more appropriate pedagogy for students’ competency development. Following the curriculum revision, 2 years worth of participants exhibited much higher mean gains in IDI scores, as well as higher rates of shifting to a new stage of effectiveness by semester’s end.

Conclusions

This study contributes to the STEM education literature by attempting to apply several years of research findings about effective intercultural competence development, principally from study abroad programs, to STEM education in on-campus contexts. In so doing, it has implications for how STEM educators can more effectively work towards cultivating global-ready STEM graduates, and towards reaching STEM students who, for whatever reason, do not typically participate in study abroad.
Feasibility and implementation fidelity of a co-designed intervention to promote in-hospital mobility among older medical patients—the WALK-Copenhagen project (WALK-Cph)
Authors: Pedersen Britt Stævnsbo , Kirk Jeanette Wassar , Olesen Maren Kathrine , Grønfeldt Birk Mygind , Stefánsdóttir Nina Thórný , Brødsgaard Rasmus , Tjørnhøj-Thomsen Tine , Nilsen Per , Andersen Ove , Bandholm Thomas , Pedersen Mette Merete
Published: April 2022

Background

Mobility interventions can prevent functional decline among older patients, but implementation of such interventions may be complicated by barriers in the clinical setting. The WALK-Copenhagen project (WALK-Cph) is aimed at promoting a 24-h mobility among older medical patients during hospitalization. The WALK-Cph intervention was co-designed by researchers and stakeholders to tailor the intervention to the clinical context. The aim of this study was to investigate the feasibility and implementation fidelity of the WALK-Cph intervention before evaluating clinical effectiveness in a randomized controlled trial (ClinicalTrials.gov NCT03825497).

Methods

The WALK-Cph intervention consisted of six components: a welcome folder explaining the importance of in-hospital activity, a WALK-plan prescribing up to three daily walking sessions during and after hospitalization, a WALK-path in the hallway that patients were motivated to use daily, exercise posters in the hallways and bedrooms, self-service on beverages and clothes, and discharge with a WALK-plan. The present study reports on phase 2 of WALK-Cph and consists of a feasibility and a fidelity component. The study was conducted at the two WALK-Cph intervention departments after the initiation of the WALK-Cph intervention. A cohort of older medical patients (+65) was recruited for the feasibility study to assess recruitment and data collection procedures and the method for assessment of activity. Simultaneously, implementation fidelity was assessed by observing clinical practice and intervention delivery at the intervention departments.

Results

A feasibility cohort of 48 patients was included. Inclusion was considered feasible with recruitment rates between 62% and 70% of all eligible patients. Also, data collection was conducted without obstacles, and all patients accepted to wear activity monitors. The fidelity observations showed that three of the six intervention components were partially implemented as planned whereas three components were not implemented as planned.

Conclusion

The WALK-Cph intervention was found feasible, and although the intervention was not implemented with fidelity, the level of fidelity was considered sufficient to continue with further testing of the WALK-Cph intervention in a large-scale trial.

Trial registration

ClinicalTrials.gov NCT03825497 (retrospectively registered). Protocol PubMed ID (PMID): 29523569.
Confirmatory factor analysis of the Dutch Screening Visual Complaints questionnaire in people with multiple sclerosis
Authors: van der Feen Fleur E. , de Haan Gera A. , van der Lijn Iris , Fuermaier Anselm B. M. , Heersema Thea J. , Meilof Jan F. , Heutink Joost
Published: April 2022

Background

Visual complaints among people with multiple sclerosis (pwMS) are common, but often difficult to recognize. The Screening Visual Complaints questionnaire (SVCq) has been developed to screen for visual complaints in people with a neurodegenerative disease, including multiple sclerosis (MS). A previous study performed a factor analysis in a normal population which revealed an acceptable one-factor model, a three-factor model and a five-factor model within the SVCq. To increase the usability of the SVCq in people with MS, the purpose of the current study was to investigate the fit of the three models in a cohort of pwMS.

Results

The confirmatory factor analysis on the SVCq in 493 people with MS showed good fit for all the models. The three-factor model (diminished visual perception, altered visual perception and ocular discomfort) outperformed the one-factor model. The five-factor model outperformed both models, which showed that dividing the first factor (diminished visual perception) into three more factors (function-related, luminance-related and task-related) has merit.

Conclusions

All models may be useful in clinical care for pwMS. The one-factor model may give a quick overview of the presence and severity of visual complaints in general. The individual factors, of either the three- or the five factor models, may contribute to a better recognition of the nature of visual complaints in pwMS and may guide further steps in rehabilitation for pwMS with visual complaints.
Misclassification of nodal stage in gastric cancer: 16 lymph nodes is not enough
Authors: Miftode Sorin , Bruns Helge
Published: April 2022

Background

In gastric cancer, nodal stage plays an important role. Insufficient lymph node harvesting or incomplete examination may lead to misclassification and affect postoperative strategy and group survival. This study’s objective was to determine the minimum number of examined lymph nodes needed in gastric cancer and compare this to the minimum lymph node count according to the current Union for International Cancer Control (UICC) classification using real world data.

Methods

Based on anatomical data, expected mean lymph node counts and their 95% confidence intervals for complete D2 lymphadenectomy were calculated. Using stochastic analysis, a threshold for correct classification in 95% of cases was determined. Survival data of nodal negative gastric cancer patients was extracted from the Surveillance, Epidemiology, and End Results (SEER)-Database for 2010–2017. Patients reaching at least the calculated theoretical threshold were compared to the minimum threshold according to the current UICC classification.

Results

The expected lymph node count was 30 (95% CI: 28–32; range 17–52), corresponding to a 27 lymph nodes. In nodal negative patients with exactly 16 and at least 27 examined lymph nodes, relative 5 year survival was 79 and 89% in T1/T2 and 39 and 64% T3/T4 gastric cancer, respectively. Theoretically, when only 16 lymph nodes are analyzed, nodal negative staging may be incorrect in up to 47% of cases.

Conclusions

A minimum threshold of 16 examined lymph nodes cannot be justified. Retrospective analysis confirmed systematic misclassification of patients with insufficient lymphadenectomy in nodal negative gastric cancer patients. Correct lymphadenectomy and thorough examination of the surgical specimen is mandatory.
Suppressing migration noise in reverse time migration of vertical seismic profiles by multiple stacking estimation
Authors: Guo Xuebao , Shi Ying , Wang Weihong , Ke Xuan , Wang Yanghua
Published: April 2022

Reverse time migration (RTM) has advantages of imaging steep dip structures but may inevitably produce migration swings when applied to vertical seismic profiles (VSPs). These artifacts often are not suppressed by stacking over shots. The noise is mainly generated from the limited coverage of VSP acquisition geometry, which leads to uneven superposition. The noise is processed by the imaging condition and then overlaps with the real layers, generating artificial images with different dip angles that are difficult to distinguish. The difference is that the real layers can be enhanced by the redundancy of multifold data, whereas the noise is usually generated by a smaller subset of the data. A VSP RTM processing flow is developed to suppress this type of noise. This method constructs the dip angle gather and estimates the redundancy of the coverage in the dip domain. In the stratigraphic dip domain, the false structure and the real structure are located at different dip angles. The real dip is determined by identifying the center of the stacking number. Then, the noise is suppressed by attenuating the imaging information of the other dip angles. The efficient wavefield decomposition method based on Hilbert transform-based instantaneous wavenumber method is adopted to determine the wave propagation direction. Compared with the Poynting vector method and the instantaneous wavenumber method, this approach alleviates the influence of multiwave arrivals and is suitable for complex media, ensuring the accuracy of image decomposition. The whole process is data-driven and does not require prior information. Theoretical and field examples indicate that this method can significantly reduce migration noise and improve the image quality of VSP RTM.
Efficient wavefield separation by reformulation of two-way wave-equation depth-extrapolation scheme
Authors: You Jiachun , Pan Naide , Liu Wei , Cao Junxing
Published: April 2022

In two-way wave-equation depth migration by either time extrapolation or depth extrapolation, an efficient wavefield separation scheme (to separate two-way wavefields into their one-way counterparts: down- and upgoing waves) is typically required for high-quality imaging. For a depth-extrapolation scheme, this wavefield separation is conventionally accomplished by using two wavefields, the pressure p and its derivative [Formula: see text]. However, that wavefield separation scheme presents a significant challenge in the accuracy and the computational cost for two-way wave-equation-based depth migration. To address this challenge, we have developed a new wavefield separation algorithm for a two-way wave-equation depth-extrapolation scheme, in which a new pressure wavefield q is introduced to replace the pressure derivative wavefield [Formula: see text] in boundary conditions and propagator of the conventional formulation. Because the pressure wavefield p represents the sum of down- and upgoing waves, whereas the pressure wavefield q denotes the difference between down- and upgoing waves, wavefield separation in the new algorithm becomes very simple and efficient — a summation and subtraction operation only at each depth step. The performance of our algorithm for wavefield separation is verified and demonstrated by numerical experiments conducted on several synthetic models. These experiments include examples of wavefield separation of the source and the receiver, migration tests on the 2D SEG/EAGE salt model (regarding one-way versus two-way depth extrapolation and comparison of evanescent-wave-suppression methods), and turning wave migration tests on three complex velocity models: the step model, the salt dome model, and the BP salt model.
Defining Reference Ranges for Serum Anti-Müllerian Hormone on a Large Cohort of Normozoospermic Adult Men Highlights New Potential Physiological Functions of AMH on FSH Secretion and Sperm Motility
Authors: Benderradji Hamza , Barbotin Anne-Laure , Leroy-Billiard Maryse , Prasivoravong Julie , Marcelli François , Decanter Christine , Robin Geoffroy , Mitchell Valérie , Rigot Jean-Marc , Bongiovanni Antonino , Sauve Florent , Buée Luc , Maurage Claude-Alain , Cartigny Maryse , Villers Arnauld , Prevot Vincent , Catteau-Jonard Sophie , Sergeant Nicolas , Giacobini Paolo , Pigny Pascal , Leroy Clara
Published: April 2022

Background

Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined in a large cohort.

Objective

In this study, we aimed, first, to establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Second, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters.

Methods

This single-center retrospective study included 578 normozoospermic adult men. Serum AMH concentrations were determined with an automated sandwich chemiluminescent immunoassay.

Results

The median serum AMH was 43.5 pmol/L. The 2.5th and 97.5th percentile values for serum AMH and AMH/tT were 16.4 and 90.3 pmol/L and 0.45 and 3.43, respectively. AMH was positively correlated with inhibin B and sperm concentration and negatively correlated with age, follicle-stimulating hormone (FSH), and progressive sperm motility. Interestingly, using immunofluorescence, we documented for the first time that AMH type II receptor (AMH-R2) is expressed in ejaculated human spermatozoa and gonadotrophic cells in the postmortem pituitary gland.

Conclusions

We establish a new age-specific reference range for serum AMH and AMH/tT. Moreover, AMH-R2 expression in human spermatozoa and gonadotrophic cells, together with the relationship between serum AMH levels and sperm motility or mean FSH levels, highlight new potential functions of AMH in regulating sperm motility or FSH secretion in adult men.
Jumonji Domain–containing Protein-3 (JMJD3/Kdm6b) Is Critical for Normal Ovarian Function and Female Fertility
Authors: Roy Sambit , Sinha Niharika , Huang Binbin , Cline-Fedewa Holly , Gleicher Norbert , Wang Jianrong , Sen Aritro
Published: April 2022

In females, reproductive success is dependent on the expression of a number of genes regulated at different levels, one of which is through epigenetic modulation. How a specific epigenetic modification regulates gene expression and their downstream effect on ovarian function are important for understanding the female reproductive process. The trimethylation of histone3 at lysine27 (H3K27me3) is associated with gene repression. JMJD3 (or KDM6b), a jumonji domain–containing histone demethylase specifically catalyzes the demethylation of H3K27me3, that positively influences gene expression. This study reports that the expression of JMJD3 specifically in the ovarian granulosa cells (GCs) is critical for maintaining normal female fertility. Conditional deletion of Jmjd3 in the GCs results in a decreased number of total healthy follicles, disrupted estrous cycle, and increased follicular atresia culminating in subfertility and premature ovarian failure. At the molecular level, the depletion of Jmjd3 and RNA-seq analysis reveal that JMJD3 is essential for mitochondrial function. JMJD3-mediated reduction of H3K27me3 induces the expression of Lif (Leukemia inhibitory factor) and Ctnnb1 (β-catenin), that in turn regulate the expression of key mitochondrial genes critical for the electron transport chain. Moreover, mitochondrial DNA content is also significantly decreased in Jmjd3 null GCs. Additionally, we have uncovered that the expression of Jmjd3 in GCs decreases with age, both in mice and in humans. Thus, in summary, our studies highlight the critical role of JMJD3 in nuclear–mitochondrial genome coordination that is essential for maintaining normal ovarian function and female fertility and underscore a potential role of JMJD3 in female reproductive aging.
The Impact of Neoadjuvant Chemotherapy on the Surgical Management of Colorectal Peritoneal Metastases: A Systematic Review and Meta-Analysis
Authors: Flood Michael P. , Kong Joseph C. H. , Wilson Kasmira , Mohan Helen , Waters Peadar S. , McCormick Jacob J. , Warrier Satish K. , Tie Jeanne , Ramsay Robert , Michael Michael , Heriot Alexander G.
Published: April 2022

Background

Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is a well-recognised treatment option for the management of colorectal peritoneal metastases (CRPM). However, incorporating the routine use of neoadjuvant chemotherapy (NAC) into this management plan is controversial.

Methods

A systematic review and meta-analysis were conducted to evaluate the impact of neoadjuvant chemotherapy on perioperative morbidity and mortality, and long-term survival of patients with CRPM undergoing CRS and HIPEC.

Results

Twelve studies met the inclusion criteria (n = 2,463 patients). Ten were retrospective cohort, one was prospective cohort, and one was a prospective randomised by design. Patients who received NAC followed by CRS and HIPEC experienced no difference in major perioperative morbidity and mortality compared with patients who underwent surgery first (SF). There was no difference in overall survival at 3 years, but at 5 years NAC patients had superior survival (relative risk [RR] 1.31; 95% confidence interval [CI] 1.11–1.54, P < 0.001). There were no differences in 1- and 3-year, disease-free survival (DFS) between groups. Study heterogeneity was generally high across all outcome measures.

Conclusions

Patients who received neoadjuvant chemotherapy did not experience any increase in perioperative morbidity or mortality. The potential improvement in 5-year overall survival in patients receiving NAC is based on limited confidence due to several limitations in the data, but not sufficiently enough to curtail its use. The practice of NAC in this setting will remain heterogeneous and guided by retrospective evidence until prospective, randomised data are reported.
A pseudo-metric structure on interpolation functors
Authors: Kaijser Sten , Sigstam Kibret Negussie
Published: April 2022

We consider topological properties of sets of interpolation functors. In particular we construct a distance function for describing nearness of interpolation functors. The idea of this paper is inspired by the concept of Banach-Mazur distance between Banach spaces.
Some dual Tauberian embeddings
Authors: Nygaard Olav
Published: April 2022

We show that if the famous construction of Davis, Figiel, Johnson and Pełczyński [1] is worked out on a weak-star compact set in a dual Banach space, then the resulting Banach space is a dual space. Next we apply this result to show that either a set is weak-star thick or it is contained in the operator range of a weak-star continuous Tauberian embedding. This result improves and, in some sense, completes the theory of thin sets and surjectivity described in [8].
On α-nuclearity and total accessibility for some tensor norms α
Authors: Kaijser Sten , Reinov Oleg
Published: April 2022

For a tensor norm α on the class of all Banach spaces there is a natural way to define the Banach operator ideal Nα associated with the tensor norm. We give sufficient conditions for an operatorto be in Nα  if its second adjoint posesses this property. We show one way to get from this the negative answers to some questions of A. Defant and K. Floret: their tensor norms g∞, w1 and w∞ are not totally accessible.
On transitivity of M(r,s)-inequalities and geometry of higher duals of Banach spaces
Authors: Haller Rainis
Published: April 2022

In this note we study the transitivity of M(r,s)-inequalities and geometry of higher duals of Banach spaces. Our main theorem shows that if X and Y are closed subspaces of a Banach space Z such that X is an ideal satisfying the M(r,s)-inequality in Y and Y is an ideal satisfying the M(r,s)-inequality in Z, then X is an ideal satisfying the M(r/(2−r),s/(2−r))-inequality in Z. This extends the corresponding result for M-ideals. As an application we show that if a Banach space X is an ideal satisfying the M(r,s)-inequality in its bidual, then X is an ideal satisfying the M(r/(r+n(1−r)),c/(r+n(1−r)))-inequality in its dual space of order 2n for every n∈N. It follows that if X is an ideal satisfying the M(1,s)-inequality in its bidual, then X has the strong uniqueness property SU in all its duals of even order. These results generalize the corresponding results for M-ideals established by  Rao [R].
Stability of the spline collocation method for Volterra integro-differential equations
Authors: Oja Peeter , Tarang Mare
Published: April 2022

Numerical stability of the spline collocation method for Volterra integro-differential equations is investigated and the connection between this theory and the corresponding theory for Volterra integral equations is explored. A series of numerical tests is presented.
Approximation by Kantorovich type operators
Authors: Rempulska Lucyna , Skorupka Mariola
Published: April 2022

We study approxiamtion properties of the Kantorovich type operators associated with the Szasz-Mirakyan and Baskakov operators. We prove that the approximation order of smoothness functions by considered operators is better than for the classical Szasz-Mirakyan and Baskakov operators given in [2]. Our paper is motivated by results obtained in [2], [6], [9] and [12].
Estimating parameters of stochastic differential equations using a criterion function based on the Kolmogorov-Smirnov statistics
Authors: Filatova Daria , Grzwaczewski Marek , McDonald David
Published: April 2022

We introduce a method for the estimation of stochastic differential equation coefficients from panel data. The method involves matching the distribution of the experimental/field data with a panel of simulated data generated by a Monte Carlo experiment. The fit between the two distributions is assessed by means of Kolmogorov-Smirnov goodness-of-fit statistic leading to a confidence function computed from an incomplete gamma function. A numerical optimization algorithm then optimizes the choice of parameters to maximize this function.
Preservation of stochastic order in R^2 under random rotations
Authors: Pincus Richard
Published: April 2022

For a specified order relation in R2, it is shown that a shift parameter family of distributions remains stochastically ordered, if it is transformed by random orthogonal rotations. The result has applications in monotonicity problems of the roots of Wishart matrices.
On descent theory for distributors
Authors: Laan Valdis , Penjam Pille
Published: April 2022

We give necessary and sufficient conditions for equalizer preservation of the functor of tensor multiplication by a distributor and some sufficient conditions for a functor between small categories to be an effective descent functor.
Free-lunch learning and directional distributions in artificial neural networks
Authors: Jupp Peter E. , Stone James V.
Published: April 2022

Free-lunch learning (FLL) is a phenomenon in which relearning partially-forgotten mental associations induces recovery of otherassociations. FLL occurs also in artificial neural networks (ANN’s). Two models for forgetting in ANN’s are presented which involve uniform distributions on spheres and Grassmann manifolds. It is shown that these models differ markedly in their amounts of FLL.
Prescribing in hypertension
Authors: Robertson Deborah
Published: April 2022

Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
When should pharmacological cognitive enhancers be used?
Authors: Winter George
Published: April 2022

The use of cognitive enhancers are associated with the treatment of medical disorders such as dementia and ADHD, but what are the ethical-clinical considerations surrounding them being taken in non-clinically prescribed circumstances?
Audit and re-audit of medication use in patients with impaired kidney function
Authors: Allison Katie
Published: April 2022

Background:

Medications prescribed for patients with chronic kidney disease (CKD) often require dose adjustments to ensure safety and efficacy. An audit was undertaken in primary care to assess how appropriate current medication use is in this patient cohort.

Aim:

To identify medications most likely to be prescribed at inappropriate doses in patients with CKD 3-5.

Methods:

Level 2 medication reviews were carried out by a clinical pharmacist for patients with a diagnosis of CKD level 3-5. The reviews focused on how appropriate medication use/dosages were where dose reduction or discontinuation would be recommended for patients with poor renal function. The audit was repeated a year later.

Findings:

Drugs that required creatinine clearance (CrCl) to be calculated had the most interventions: eight patients had dose changes implemented for rivaroxaban.

Conclusion:

The use of the correct calculation and regular review to assess the use and dose of medications in patients with poor renal function is vital in improving health outcomes.
A warfarin-antibiotic drug-drug interaction: a podiatric surgical case report
Authors: Feeney Sally , Rees Sharon , Modha Ravi Krishān
Published: April 2022

Several groups of antibiotics are known to interact with warfarin, presenting a challenge to the prescriber trying to manage underlying clinical infection, whilst mitigating the risk of coagulopathy. The authors present a case report of a 64-year old warfarinised patient who underwent forefoot surgery and developed a subsequent post-operative infection with combinations of antibiotics, leading to excessive anticoagulation and an adverse drug event. From reviewing both local and national guidance, careful monitoring is mandatory, dosing adjustments and pre-emptive dose reduction might also be needed. Consultation within the wider multi-disciplinary network will be central to decision making and implementing safety netting measures.
O Experimento de Queda de Corpos na Perspectiva Epistemológica
Authors: De Jesus José Carlos Oliveira , Alves Álvaro Santos , Burnham Teresinha Fróes
Published: April 2022

Neste trabalho, discute-se o clássico experimento de queda de corpos segundo uma perspectiva epistemológica, ressaltando-se a colocação do problema físico, a construção de hipóoteses e a escolha dos referenciais teóricos. Enfatiza-se principalmente o papel que esses elementos desempenham na elaboração da metodologia de trabalho experimental, desde a escolha das variáveis relevantes ao contexto teórico em foco, passando pela montagem do experimento até a coleta de dados. Além disso, a análise e discussão dos resultados, bem como a conclusão, estão inapelavelmente ligados ao horizonte teórico previamente estabelecido. As impressões aqui registradas são frutos de uma experiência didática realizada junto a turmas de Física Experimental I do Curso de Graduação em Física da Universidade Estadual de Feira de Santana durante o semestre letivo 2004.2.
Sobre os Sistemas de Referência Celeste
Authors: Martin V.A.F , Poppe P.C.R.
Published: April 2022

Apresentamos neste trabalho algumas discussões sobre os Sistemas de Referência utilizados em Astronomia. Claramente, não é possível esgotar todo este assunto num único texto, mas esperamos, contudo, que o presente material possa ser apreciado nos cursos de Introdução à Astronomia, queestão cada vez mais presentes nas atuais propostas curriculares das graduações de Física. As discussões pertinentes às "Bases de Referência Celeste" (Celestial Reference Frame), serão apresentadas em um outro trabalho.
Sobre as Bases de Referência Celeste
Authors: Poppe P.C.R. , Martin V.A.F.
Published: April 2022

Ao longo deste artigo, apresentamos, como continuidade à discussão apresentada no trabalho anterior [1], uma primeira discussão sobre algumas das principais bases de referência utilizadas em Astronomia. Da mesma forma, esperamos que o presente texto possa ser utilizado ao longo doscursos de Introdução À Astronomia das atuais graduações de Física e áreas afins.
Projectifying feminism: exploring the conditions for feminist politics in international development aid
Authors: Scott David , Rönnblom Malin
Published: April 2022

As an organisational form, the project poses a challenge today for the possibility of articulating feminist politics, understood as feminist visions and ambitions. With a focus on women’s organisations working in international development aid, we examine how the project format and its managerial attributes shape the possibility of articulating feminist politics. Mobilising assemblage thinking on a material consisting mainly of interviews with project workers in women’s organisations, we show that these organisations engage in assembly work to fit their activism with the project format, such as translating feminist ambitions into bureaucratic procedures and notions of temporality, activating repertoires of expertise, and adopting marketised approaches to development. We conclude that the project format depoliticises feminist politics, although it does not make the articulation of feminist ambitions impossible. Assemblage thinking is suggested as a suitable framework for feminist research when investigating how contemporary governing arrangements influence the articulation of feminist politics.
Does the gender composition of the board of directors have any effect on tax aggressiveness in western countries?
Authors: Cortellese Francesco
Published: April 2022

Women constitute more than half of the population, but they are still underrepresented in areas such as company boardrooms. This study analyses whether having an equal gender composition in a company’s board of directors would reduce tax aggressiveness. We use panel data from 2015 to 2019 taken from a sample of listed companies in the USA, the UK, Switzerland, Sweden, Spain, the Netherlands, Germany, and France. Women remain underrepresented in most of the countries in our sample, never exceeding one-third of board members. The results of the model are mixed. The gender composition of the board is not statistically significant in explaining tax aggressiveness except for in three countries: in the USA and the UK, an increase in women on the board produces an increase in tax aggressiveness, while in Switzerland, there is the opposite effect. We conclude that governments should promote policies for equality in the boardroom and a fairer tax system because, even if they are not clearly related, they are the basis for socio-economic development. Lastly, future research should include tests on non-listed companies and other variables on board diversity in the analysis.
Digital marketing employability skills in job advertisements – must-have soft skills for entry level workers: A content analysis
Authors: Kovacs Ildiko , Vamosi Zarandne Kornelia
Published: April 2022

The aim of the study is to explore the employers' demands for personal skills in graduate and junior positions in the field of digital marketing. The research summarizes the review of academic literature on transferable soft skills, focusing on the digital marketing sector. Job requirements in digital marketing related to graduate and junior employability skills are studied for the following occupations: junior digital marketing manager, social media manager and digital marketing manager assistant. The article presents the findings of a content analysis of 5548 digital marketing job advertisements downloaded in February 2021, in a period of one month, from the top five job finding websites in Hungary. The authors’ classification framework includes a core set of relevant skills and competences that can be used to conduct the assessment. Thirty-one most frequently mentioned soft and hard skill categories are grouped into five main categories and analyzed with quantitative methods. Within the scope of the study, an occurrence frequency analysis is conducted in job advertisement texts and the data is analyzed with descriptive statistical methods. Moreover, the findings cover the importance of foreign language knowledge and software knowledge as they appear in job ads. The differences between foreign and multinational companies’ soft skill requirements are still under examination. The data show that, while hard skills in job advertisements are still dominant, soft skills are also emphasized in the field of digital marketing. In analyzing the results, the authors look at what employers focus on when searching for graduate students and employees for junior positions. The academic and practical implications of the study are useful for further research, as it presents a collection of essential digital marketing employability skills.
International differences in patriotic entrepreneurship – the case of Poland and Ukraine
Authors: Sułkowski Łukasz , Ignatowski Grzegorz , Stopczyński Bartłomiej , Sułkowska Joanna
Published: April 2022

Objective: The aim of the paper is to examine whether the impact of patriotic entrepreneurship may differ from the perspective of buyers depending on the country in question and how it affects entrepreneurial behaviour. Methods: The method are semi-structured interviews with entrepreneurs and management and economics students from two countries who were introduced to the main elements that make up the concept of patriotic entrepreneurship and an online survey conducted among students coming from the two countries using questionnaire data will be mentioned. Results: Both quantitative and qualitative research indicated that most respondents understand and are willing to be guided by principles that take it into account. At the same time, the differences in the behaviour of entrepreneurs and buyers in Poland and Ukraine show that the very concept of this entrepreneurship, not supported by a strong economy and an attractive offer of domestic enterprises, will remain only a theoretical concept, not implemented in practice. Conclusions: Patriotic entrepreneurship can be one of the important motivations for consumer, managerial and employee actions. The research should be continued in the future. Other countries should be selected to see if there is a correlation that the intensity of patriotic entrepreneurship increases as the economic level rises. It would also be useful to investigate whether the attachment to local brands increases as the competitiveness of their offer improves.