bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of resistant exercise on the cardiorespiratory fitness of the elderly: a systematic review
Authors: Konzen Vanessa , Oliveira Murilo , Schneider Rodolfo , Wibelinger Lia
Published: May 2024

Introduction: Oxygen consumption is a physical condition that presents a significant decline due to aging. Resistance training has demonstrated efficiency in delaying some harmful effects of advancing age, however, the influence on the cardiorespiratory capacity of the elderly requires further elucidation. Objective: To elucidate the impact of resistance exercise programs on the cardiorespiratory fitness of healthy elderly people. Methods: This is a systematic review of randomized clinical trials searched in 9 databases, with the following keywords: “resistance training”, “elderly” and “cardiorespiratory fitness”. Results: 6 studies were selected for the review and showed that the elderly population, when subjected to resistance training programs, obtains gains in VO2 adaptations when evaluated through cardiorespiratory tests. The gain was greater in those who associated aerobic exercise with resistance training. Conclusion: Elderly people undergoing resistance training obtain an improvement in cardiorespiratory fitness, with its benefits increased when resistance training is associated with aerobic training (combined exercise).
Utilization of passion fruit (Passiflora cincinnata Mast.) peel flour in sweet preparation
Authors: Chauca Milton Nobel Cano , Silva Daniela Rodrigues , Neves Taiza Muniz , Ngolo Priscille
Published: May 2024

The aim of this study was to develop sweets added with flour from wild passion fruit peel and evaluate their physicochemical and sensory quality. The sweets were prepared using formulations of 0%, 10%, 15%, 20%, and 25% of passion fruit peel flour and concentrated until reaching 55 °Brix, except for the 0% formulation, which was concentrated until 65 °Brix. Physicochemical analyses of moisture, pH, titratable acidity, and ash, texture, color, and sensory evaluation were conducted. The results indicated that the sweets had appropriate values for moisture, pH, titratable acidity, and ash. Texture analysis revealed that the sweets had texture values ranging from 1.0 to 5.0 N, with formulations containing added flour being firmer. Regarding color, the Lab* parameter showed that the sweets resulted in shades of white, slightly green, and yellowish depending on the addition of flour. Sensory analysis demonstrated that all sweets were well-accepted, achieving scores above 6.0 points. It was concluded that the sweets exhibited texture and color characteristics typical of passion fruit sweets and good sensory acceptability, thus representing a viable option to add greater value to the product.
An Experimental Study of Oil Fields Scale Analysis and Dissolution Test Using Acidizing Fluids
Authors: Dankwa Ohenewaa Kakra
Published: May 2024

Formation damage reduces permeability of reservoirs thereby reducing well productivity. One of the methods that is used to remove formation damage is acidization. Oilfield scales are basically mineral scales that are formed during petroleum production and have the tendency to cause wellbore damage. Formation of oilfield scales result predominantly from over saturation of dissolved minerals in oil and gas produced water. In this study, scale samples have been analysed and identified using x-ray diffractometry. X-Ray diffractometry was used to identify minerals present in the wellbore scales. The X-Ray diffractometry results confirmed the presence of seventeen different minerals in the scales and these have been classified as carbonates, silicates and phosphates. Matrix acidizing fluids have also been designed and formulated to test the capability to dissolving the scales. 10% and 15% HCl (regular acids) as well as xylene and diesel were used on the scales to ascertain their dissolution capabilities. None of these three fluids was able to completely dissolve the sample scales because the mineralogical compositions revealed by XRD were mainly the HCl insoluble minerals such as Petalite, Xenotite, etc. Only 10% mineral composition of the scales identified were HCl soluble. The results of this study prove that, X-Ray Diffractometry must precede any action taken to remove/treat oilfield scales, especially when considering chemical dissolution. This will prevent wastage and save money and time.
Análise do perfil epidemiológico das infecções do trato urinário na mesorregião noroeste do Espírito Santo
Authors: Fedeszen Estêvão Kubit , Rocha Leonardo Dias Flor , Mischiatti Jamily de Souza , Loss Humberto Moreira , Ferreira Filipe de Carvalho Emery , Castro Fernanda Cristina de Abreu Quintela , Chiarelli-Neto Orlando , Rossoni Junior Joamyr Victor , Barcelos Rafael Mazioli , Marcolongo-Pereira Clairton
Published: May 2024

INTRODUÇÃO: As infecções do trato urinário (ITUs) são algumas das infecções bacterianas mais comuns, afetando cerca de 150 milhões de pessoas a cada ano em todo o mundo. As ITUs afetam principalmente mulheres e são causadas por uma variedade de uropatógenos, sendo Escherichia coli o mais comumente isolado. OBJETIVO: Investigar as características clínicas e epidemiológicas das ITUs diagnosticadas na mesorregião noroeste do Espírito Santo, contribuindo para uma compreensão mais profunda desta condição na região. METODOLOGIA: Trata-se de um estudo de caráter descritivo, retrospectivo, transversal e quantitativo, baseado na análise de prontuários médicos de pacientes portadores de ITUs com confirmação diagnóstica registrados nos serviços Clínica Médica e Laboratório de Análises Clínicas de um hospital localizado na mesorregião noroeste do Espírito Santo no período de 2016 a 2022. Foram calculadas as taxas de incidência, além das frequências relativas e absolutas. RESULTADOS: Durante o período analisado, foram registrados 62 casos de ITUs. Notou-se maior prevalência em crianças e idosos do sexo feminino. Os uropatógenos mais frequentemente identificados foram E. coli e Klebsiella pneumoniae. Quanto aos sintomas/sinais clínicos, os mais comumente relatados pelos pacientes incluíam febre, disúria e vômitos, indicando a variedade e a severidade dos sintomas associados a esta condição. CONCLUSÃO: Este estudo contribui para a compreensão da dinâmica das ITUs na mesorregião noroeste do Espírito Santo e sublinha a importância de práticas clínicas baseadas em evidências para lidar com esta condição.
Matéria seca e alocação da biomassa de Guadua angustifólia Kunth presente no BAG BAMBU da UFAL
Authors: Salvador Taciana de Lima , Lemos Eurico Eduardo Pinto de , Lemos Eurico Eduardo Pinto de , Silva José Vieira , Silva José Vieira , Alves Gilberto Dias , Rezende Leila de Paula , Salvador Tatiana de Lima
Published: May 2024

Grande sequestrador de carbono aliado a uma alta taxa de crescimento, o bambu possui metabolismo para fixação de CO2 do tipo C4, possuindo uma maior eficiência em economia de água devido ao seu controle estomático, sendo este um indicador de sensibilidade ao estresse hídrico. O bambu Guadua angustifolia Kunth é uma planta lenhosa nativa da América do Sul que possui alta rusticidade e resistência, o que a qualifica para inúmeros usos que vão desde as construção civil à produção de energia, sendo considerada uma das 20 espécies de bambu mais promissoras do mundo. O objetivo deste trabalho foi avaliar a produção de matéria seca e alocação da biomassa em plantas de bambu G.angustifolia sob condições de estresse hídrico. A produção de biomassa seca dos colmos folhas e raízes foram avaliados em um experimento conduzido em blocos casualizados com fatorial 3 x 3, sendo 3 épocas de coleta (180, 270 e 360 dias) e 3 lâminas de irrigações aplicadas [Controle (80-100% da capacidade de campo com irrigações diárias); Estresse moderado (40-60% da capacidade de campo com irrigações 4 vezes por semana) e Estresse severo (0-20% da capacidade de campo com irrigações 2 vezes por semana)], com 10 repetições e uma planta por parcela. Embora a deficiencia hídrica imposta pelas lâminas de irrigação nas diferentes épocas tenha limitado durante o período de estresse a produção de materia seca dos colmos, folhas e raízes do bambu nas diferentes épocas avaliadas, a resistência e a rusticidade da espécie pode ser comprovada ao longo de todo o experimento.
Enraizamento de estacas de marula em resposta a aplicação de ácido 3-indolacético e fosfato monoamônico
Authors: Souza Mirna Ariane Taveira de Sousa e , Maia Victor Martins Maia , Santos João Rafael Prudêncio dos , Silva Bruno Soares da , Oliveira Fernanda Soares
Published: May 2024

A marula (Sclerocarya birrea) é uma espécie de origem africana com importância nutricional e medicinal, com grande potencial de produção nas regiões de clima semiárido. Por se tratar de uma espécie dióica faz-se necessário o uso de propagação vegetativa a fim de se obter plantas com maior uniformidade e vigor, reduzindo o período juvenil e antecipando a floração e produção. Objetivou-se com o presente trabalho avaliar o enraizamento de estacas da maruleira tratadas com diferentes concentrações de fosfato monoamônico (MAP) e ácido indolacético (AIA). Os experimentos foram conduzidos no viveiro de mudas da Universidade Estadual de Montes Claros do campus Janaúba, utilizando estacas semilenhosas de plantas masculinas e femininas. Utilizou-se delineamento inteiramente casualizado, no esquema fatorial 5 x 5, correspondentes as concentrações de AIA (0; 250; 500; 1000 e 2000 mg L-1) e concentrações de MAP (0; 4834,3; 9668,8; 14503,2 e 24172 mg L-1), com 5 repetições. Avaliou-se a porcentagem de estacas vivas, número de ramos ou brotações, comprimento de ramo, diâmetro da base do ramo, número de folhas, porcentagem de estacas enraizadas, matéria fresca e seca de folhas, ramos e raízes; comprimento e volume de raízes.  Foi observado média geral de 2,4% de enraizamento e 74,4% de estacas vivas para as estacas da planta feminina e 32,8% de estacas vivas e 0% de estacas enraizadas para as estacas da planta masculina. Não foram encontradas diferenças significativas entre as variáveis enraizamento e estacas vivas, em função das concentrações de AIA e MAP, não havendo promoção do crescimento das mesmas.
In vitro control of Ganoderma lucidum
Authors: De Neelanjana , Harsh N.
Published: May 2024

Control of Ganoderma lucidum, a serious root-rot pathogen of tree species has been attempted in vitro using some chemicals, fungicides and plant materials. Borax, boric acid, copper sulphate, sodium carbonate, urea and zinc chloride among chemicals at 0.5% conc.; benomyl, bitertanol, blitox, captan and topsin-M among fungicides at 0.2% conc. and turmeric powder among plant materials were effective in controlling the growth of G. lucidum. However, only borax, boric acid, copper sulphate, sodium carbonate, urea and blitox were found effective in controlling the growth of G. lucidum in wooden feeder strips when added in soil.
Evaluating Communication through Work Authorization between Dentists and Dental Technicians for Fixed Prosthesis
Authors: Bashir Anam Fayyaz , Jatala Ussamah Waheed , Ahmad Moeen ud Din , Butt Aisha Arshad , Qaiser Aneela , Munir Nadia
Published: May 2024

Communication within the dental profession can be challenging and may affect the quality of prostheses delivered to the patient. A methodical investigation into the dynamics between dentists and dental technicians is lacking in Lahore. Objective: To assess adequate practice of communication between dentists and dental technicians through work authorization for fixed prosthesis. Methods: This cross-sectional study was conducted in dental laboratories of Lahore. A questionnaire concerning work authorization forms was distributed to 80 dental technicians through Google Forms and hard copies. The survey concentrated on inquiries related to various aspects of work authorization, including gender, years of experience, impression disinfection, patient demographic data, impression materials used, fixed prosthesis design, and shade selection. An adequate work authorization was assessed in the end. Statistical analysis was conducted SPSS version 25.0 and was analyzed using chi-square, with significance set at p ≤ 0.05. Results: Out of the 80 survey forms disbursed, only 73 completely filled responses were accepted, giving a response rate of 91%. Information regarding patient demographic data (19.2%), patient photographic record (5.5%), pontic design (13.7%), margin design (37%), surfaces covered by metal (9.6%) and occlusal scheme (6.8%), were all on the inferior side of the scale ranging below 40%. Adequate practice of work authorization was discouraging, at only 17.8%. Conclusions: Poorly filled work authorization forms lead to patient and dentist dissatisfaction with fixed dental prostheses. This highlights the importance of clear communication between technicians and dentists. Dental students should learn to complete these forms during their training.
Frequency of Depressive Symptoms in Women with Polycystic Ovary Syndrome and Obesity versus Women with Polycystic Ovary Syndrome without Obesity
Authors: Faryal Sheeba , Nighat Ayesha , Ahmed Adnan , Bashir Saba , Liaquat Farah , Shah Hanozia
Published: May 2024

Polycystic Ovary Syndrome (PCOS) is a complicated hormonal condition that impacts women globally. Its association with obesity and its potential impact on mental health, specifically depressive symptoms, has gained increasing attention. This study aimed to determine the relationship between depressive symptoms and PCOS in women, with a focus on the influence of obesity. Objective: To compare the frequency of depressive symptoms among women who have PCOS, categorized based on whether they are obese or not. Methods: A cross sectional descriptive study was conducted on electronic medical records of 194 women with PCOS from a tertiary care hospital. Data included demographic information, clinical characteristics of PCOS, and depressive symptom scores measured using the Center for Epidemiologic Studies-Depression (CES-D) scale. The study was conducted from Apr 2021 to Oct 2021 for a period of 6 months. Results: Women with PCOS and obesity exhibited significantly higher mean CES-D scores and a higher prevalence of clinically significant depressive symptoms (CES-D ≥ 16) compared to those without obesity. Hyperandrogenism, oligomenorrhea, and hirsutism were more prevalent in women with PCOS and obesity. Conclusions: The study found out that women with PCOS and obesity appear to be at a higher risk of experiencing clinically significant depressive symptoms. Healthcare providers should consider the mental health needs of this population, emphasizing a multidisciplinary approach to care.
Feasibility of My Chicken Restaurant Business Development in Bulukumba Regency
Authors: Syam Agus , Pertiwi Wiwi , Halim Nur , Jufri Muhammad , Sudarmi Sudarmi
Published: May 2024

This research aims to determine the feasibility of opening a new branch at the My Chicken restaurant on Jalan Poros Tanjung Bira, Bulukumba district. This research uses a qualitative approach. Data collection was carried out through observation, interviews and documentation techniques. The collected data is processed using data reduction steps, data presentation, and drawing conclusions/verification. The results of this research show that, based on the marketing aspect, the My Chicken restaurant is worthy of development, but must continue to carry out evaluations to continue developing new strategies in new locations. From a technical aspect, it is feasible to carry out, however there needs to be improvements in the technology and machines used in the My Chicken restaurant production process. From socio-economic and environmental aspects, it is feasible because it can provide positive benefits and the My Chicken restaurant will manage and be responsible for the waste produced
Analisis dan Perancangan Sistem Informasi Penyaluran Dana Zakat berbasis Web menggunakan Framework Laravel: Studi Kasus di Yayasan Baitul Maal PLN Depok
Authors: Munir Sirojul , Surya Tubagus Muhammad Billal Zakky
Published: May 2024

Yayasan Baitul Maal PLN Depok adalah salah satu lembaga amil zakat nasional yang saat ini dalam pengelolaan administrasinya YBM PLN masih menggunakan cara manual yaitu dengan menerima berkas pengajuan dan  menentukan waktu agar bisa berdiskusi dengan manajemen YBM PLN barulah diambil keputusan dari hasil diskusi tersebut. Cara tersebut sangat memakan waktu yang lama, karena seorang amil yang menerima berkas pengajuan tersebut harus menunggu waktu senggang dari manajemen YBM PLN tersebut. Dalam membangun sistem ini dilakukan tahapan pengumpulan data dengan studi pustaka dan studi lapangan, Tahapan desain dan pengembangan sistem menggunakan pemodelan diagram Unified Modeling Language dan model pengembangan Extreme Programming. Berdasarkan hasil dari pengujian black box terhadap fungsionalitas aplikasi didapatkan persentase keberhasilan sebesar 100%. Untuk pengujian UAT didapatkan hasil 100% pada sisi super-admin, 100% pada sisi admin, 100% pada sisi amil dan 100% pada sisi pegawai. Sedangkan dari hasil kuesioner yang diberikan kepada 10 responden terkait kelayakan aplikasi, didapatkan hasil sebesar 75%. Kesimpulannya adalah aplikasi penyaluran dana zakat cukup memudahkan YBM PLN dalam memberikan keputusan terhadap pengajuan yang diterima.
Potential Estimation of Secondary Pollutant Formation of BVOC from Peltophorum pterocarpum in Urban Area
Authors: Maneejantra Suteekan , Charoenpun Thanyaporn , Bualert Surat , Choomanee Parkpoom , Janyasuthiwong Suthee , Chommon Waraporn
Published: May 2024

Cimate change affects the emission of biogenic volatile organic compounds (BVOCs) from plants, especially isoprene, α-pinene, and β-pinene. These compounds play vital role in the secondary organic aerosol potential (SOAP) and ozone formation potential (OFP) through photochemical reactions. In Thailand, daytime temperatures typically reach up to 40°C resulting in potential plant stress. The considered plant Peltophorum pterocarpum, emits high levels of BVOCs and is widely cultivated in the urban areas of Bangkok. Consequently, this research aimed to study the variations in BVOC concentration, SOAP, and OFP associated with Peltophorum pterocarpum, during the daytime. The BVOCs (isoprene, α – pinene, and β – pinene) were sampled using a dynamic enclosure system from 9:00 to 11:00 local time and analyzed using gas chromatography with a flame ionization detector. SOAP and OFP were estimated using fractional aerosol coefficient and maximum incremental reactivity. The results revealed an average BVOC concentration of 4.68 μg/m3, which depended on temperature and light intensity. The highest SOAP and OFP were 1,367.10 and 188.58 μg/m3, respectively, which were largely influenced by β – piene. This study aids in understanding the role of secondary pollutant formation involving BVOCs emitted from trees in urban areas, which can lead to the selection of low BVOC-emitting tree species and improvement of guidelines for planning urban forest areas.
MEDICAL TOURISM TRENDS AND IMPACT ON HOSPITAL SERVICES
Authors: NAGAR GOVIND
Published: May 2024

Medical tourism, a rapidly growing phenomenon in developing countries, has garnered attention as a potential economic diversification strategy. Key factors influencing medical tourism include cost, quality, language, and ease of travel. India, for instance, attracts patients due to its cost-effective healthcare services and government initiatives promoting it as a premier healthcare destination. However, despite these efforts, certain regions, such as the eastern part of Uttar Pradesh, face challenges in fully tapping into the medical tourism market. This study investigates post-COVID factors affecting medical tourism and maps them with enablers. Additionally, it employs the SERVQUAL framework to assess service quality from patient expectations and perceptions. By providing a regional promotion framework and identifying future research directions, this study contributes to the existing literature in the field of medical tourism. Keywords: Medical tourism, hospital services, healthcare, trends, impacts, cost differentials, quality of care, regulatory compliance, cultural differences, patient safety, healthcare systems.
EXAMINING THE DETERMINANTS OF VENTURE CAPITAL INVESTMENT SUCCESS IN START UP COMPANIES
Authors: SHARMA BHUVNESHWAR
Published: May 2024

The Indian startup scene has witnessed an unparalleled upsurge in recent times, garnering interest from both local and global quarters. The plethora of creative concepts, in conjunction with a favorable legislative framework and heightened accessibility to venture capital (VC) funds, has driven India to the forefront of the global startup investment landscape. In this ever-changing environment, it is imperative that researchers, practitioners, and policymakers alike focus on understanding the factors that influence venture capital investment success in Indian businesses. Especially in its early phases of development, venture capital, a type of private equity funding, is essential to the development and expansion of startups. In contrast to conventional funding options like public ownership or bank loans, venture capital offers not just cash but also industry contacts, mentorship, and strategic advice—all of which are crucial tools for start-up companies navigating the cutthroat business world. As such, the success or failure of venture capital investments has important ramifications for wider economic growth and innovation ecosystems, in addition to investors and entrepreneurs. With initiatives covering a wide range of industries, including technology, e-commerce, healthcare, finance, and agriculture, among others, India's startup environment is distinguished by its diversity and energy. The Indian startup scene is characterized by a diverse range of innovative and ambitious ventures, ranging from social enterprises tackling urgent societal concerns to disruptive technology firms upending conventional wisdom. But below all of this excitement are intricate dynamics and difficulties that influence how venture capital investments turn out. A variety of internal and external factors that interact in complex ways make up the multiple and multifactorial drivers of venture capital investment success in Indian businesses. The attractiveness of investment prospects and their potential for yielding returns are influenced by market factors, such as market size, growth potential, and competitive environment. Investors consider the caliber and competencies of the management team, which consists of executives, founders, and other important individuals, while determining the feasibility and expandability of businesses.
CONSUMER BEHAVIOURL ANALYSIS IN E COMMERCE AS MYNTRA USING DATA ANALYTICS
Authors: Nagar Anjali
Published: May 2024

"Millennials exhibit significant changes in their shopping behavior, particularly when it comes to online shopping. Their tech-savviness plays a crucial role in their affinity for online purchases. Nowadays, everything from clothing to cosmetics, electronics, and groceries is bought online. Researchers actively study the factors influencing online shopping behavior among the potential target audience. This study primarily aims to understand how demographic factors contribute to variations in online shopping behavior. Product reviews serve as a method to establish customer relativity and frame customer opinions. These reviews act as opinion leaders, shaping perceptions that become prerequisites for forming expectations. Comparing actual performance with these predetermined expectations is essential. Housewives, who spend more time on household activities, exhibit different consumer behavior toward online shopping compared to working women who spend half their day outside the house. Economic status significantly impacts preferences and needs, especially in online shopping. Age also plays a key role in consumer behavior among the potential target audience. Electronic gadgets and devices like cellphones, laptops, pen drives, and printers are predominantly purchased through online platforms. Consequently, product literature, reviews, and referencing become critical when customers visit a company’s website or a general e-commerce platform. For e-commerce companies, understanding customer traffic reasons and expectations is vital. Factors such as user interface quality, processing speed, easy payment gateways, shopping window design, extensive product comparison options, and customer reviews significantly influence purchasing decisions in the online shopping landscape." Keywords: Online Shopping, Consumer Behaviour, MarketingTechniques, Sales Promotions.
AN ANALYSIS OF EFFECTIVENESS ON DIGITAL MARKETING
Authors: MISHRA RISHABH
Published: May 2024

Finding out how effective digital marketing strategies are in the modern business environment is the driving force behind this study. With the proliferation of online services, companies are increasingly relying on digital marketing to reach customers. This study employs both quantitative and qualitative methodologies to assess several digital marketing strategies, including social media marketing, search engine optimization, content marketing, email marketing, and influencer marketing. Data from surveys, case studies, and interviews with industry specialists will be analyzed to find the most effective digital marketing tactics and trends. Analyzing this research and applying its conclusions to digital marketing strategies might teach us more about how businesses can achieve their goals and get an edge in the digital realm.
CONSUMER BUYING BEHAVIOUR REGARDING ONLINE ADVERTISMENT
Authors: SINGH PRIYA
Published: May 2024

In the era of digitization, the landscape of marketing has undergone a profound transformation. Traditional methods of advertising are gradually being overshadowed by the pervasive influence of online platforms. Among the myriad forms of online marketing, online advertising stands out as a powerful tool for reaching consumers in an increasingly interconnected world. In the context of India, a country witnessing rapid digitalization and a burgeoning online population, understanding consumer buying behavior regarding online advertisements assumes paramount importance. This introduction serves to contextualize the significance of studying consumer behavior in the realm of online advertising within the Indian market. The proliferation of the internet and the widespread adoption of smartphones have revolutionized the way businesses engage with consumers. Online advertising, encompassing various formats such as display ads, social media promotions, search engine marketing, and influencer collaborations, has emerged as a cornerstone of modern marketing strategies. Its appeal lies in its ability to target specific demographics, track user interactions, and personalize content, thereby enhancing its effectiveness compared to traditional advertising channels.
ตัวแบบสมการโครงสร้างของปัจจัยที่ส่งผลต่อความได้เปรียบทางการแข่งขันของธุรกิจนำเที่ยวฝั่งอันดามัน
Authors: ณ พายัพ นุษณา , จันทร์กิ่งทอง วิวัฒน์ , ทองพูน สิริลักษณ์ , หวังเบ็ญหมัด ชุติมา
Published: May 2024

งานวิจัยนี้มีวัตถุประสงค์เพื่อตรวจสอบตัวแบบสมการโครงสร้างของปัจจัยที่ส่งผลต่อความได้เปรียบทางการแข่งขันของธุรกิจนำเที่ยวฝั่งอันดามัน เป็นการวิจัยเชิงปริมาณ ประชากรคือ ธุรกิจนำเที่ยวในพื้นที่ฝั่งอันดามัน จำนวน 1,978 ราย ผู้วิจัยทำการสุ่มตัวอย่างอย่างง่าย ได้ขนาดกลุ่มตัวอย่าง จำนวน 360 ตัวอย่าง และใช้แบบสอบถามเป็นเครื่องมือในการเก็บรวบรวมข้อมูล จากนั้นทำการวิเคราะห์ข้อมูลด้วยโปรแกรม Lisrel version 11
ผลการวิเคราะห์ความสัมพันธ์ของปัจจัยที่ส่งผลต่อความได้เปรียบทางการแข่งขันของธุรกิจนำเที่ยวฝั่งอันดามันมีความสอดคล้องกับข้อมูลเชิงประจักษ์ โดยพบว่า RMSEA เท่ากับ 0.069 NNFI เท่ากับ 0.95 CFI เท่ากับ 0.90 และ SRMR เท่ากับ 0.015 และเมื่อพิจารณาความสัมพันธ์ของปัจจัยพบว่า นวัตกรรมทางธุรกิจส่งผลทางตรงต่อความได้เปรียบทางการแข่งขัน การจัดการทุนมนุษย์ส่งผลทางตรงต่อความได้เปรียบทางการแข่งขัน และส่งผลทางอ้อมต่อความได้เปรียบทางการแข่งขันโดยผ่านนวัตกรรมทางธุรกิจ การปรับตัวของธุรกิจส่งผลทางตรงต่อความได้เปรียบทางการแข่งขันและส่งผลทางอ้อมต่อความได้เปรียบทางการแข่งขันโดยผ่านนวัตกรรมทางธุรกิจ ซึ่งผลจากการวิจัยครั้งนี้ สามารถใช้เป็นแนวทางในการพัฒนาความได้เปรียบทางการแข่งขันของธุรกิจนำเที่ยวในพื้นที่ฝั่งอันดามันให้ดีขึ้นได้ต่อไป
ผลของพฤติกรรมการแบ่งปันความรู้ที่มีต่อผลการปฏิบัติงานของพนักงาน โดยมีพฤติกรรมการทำงานเชิงนวัตกรรมเป็นตัวแปรส่งผ่าน
Authors: ทรงทิพย์ สมฤดี , ทวีไพบูลย์วงษ์ จุฑามาศ
Published: May 2024

การวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาความสัมพันธ์ระหว่างพฤติกรรมการแบ่งปันความรู้ พฤติกรรมการทำงานเชิงนวัตกรรม และผลการปฏิบัติงานของพนักงาน รวมถึงวิเคราะห์บทบาทการเป็นตัวแปรส่งผ่านของพฤติกรรมการทำงานเชิงนวัตกรรมในความสัมพันธ์ระหว่างพฤติกรรมการแบ่งปันความรู้และผลการปฏิบัติงานของพนักงาน กลุ่มตัวอย่างได้แก่พนักงาน บริษัทผู้ผลิตอาหารเสริมแห่งหนึ่ง ในจังหวัดชลบุรี จำนวน 220 คน ใช้แบบสอบถามเป็นเครื่องมือในการเก็บข้อมูล โดยการสุ่มตัวอย่างแบบแบ่งชั้นตามสัดส่วน การทดสอบสมมติฐานการวิจัยใช้การวิเคราะห์โมเดลสมการโครงสร้าง ผลการศึกษาพบว่า โมเดลการวัดมีความเที่ยงและความตรง และโมเดลโครงสร้างความสัมพันธ์ระหว่างพฤติกรรมการแบ่งปันความรู้ พฤติกรรมการทำงานเชิงนวัตกรรม และผลการปฏิบัติงานของพนักงานมีความสอดคล้องกับข้อมูลเชิงประจักษ์ โดยมีค่า CMIN/DF = 1.657, GFI = 0.962, AGFI = 0.923, TLI = 0.984, CFI = 0.990, NFI = 0.976, RMR = 0.014, RMSEA = 0.055 การวิเคราะห์เส้นทางอิทธิพลพบว่าพฤติกรรมการแบ่งปันความรู้ส่งผลทางบวกต่อผลการปฏิบัติงานของพนักงาน พฤติกรรมแบ่งปันความรู้ส่งผลทางบวกต่อพฤติกรรมการทำงานเชิงนวัตกรรมของพนักงาน และพฤติกรรมการทำงานเชิงนวัตกรรมส่งผลทางบวกต่อผลการปฏิบัติงานของพนักงานอย่างมีนัยสำคัญทางสถิติ  และจากการทดสอบการเป็นตัวแปรส่งผ่านของพฤติกรรมการทำงานเชิงนวัตกรรม พบว่า พฤติกรรมการทำงานเชิงนวัตกรรมของพนักงานเป็นตัวแปรส่งผ่านแบบบางส่วนระหว่างความสัมพันธ์ของพฤติกรรมการแบ่งปันความรู้และผลการปฏิบัติงานของพนักงาน โดยความแปรปรวนของพฤติกรรมแบ่งปันความรู้และพฤติกรรมการทำงานเชิงนวัตกรรมสามารถอธิบายความแปรปรวนของผลการปฏิบัติงานของพนักงานได้ร้อยละ 41
Do Intra-industry Peer Effects Influence the Debt Financing Policy of Companies Listed in Thailand?
Authors: Nuanpradit Sirada
Published: May 2024

Rational imitation of financial policies, namely peer effects, was documented to prevail among firms within an industry in both developed and top emerging economies. Lacking evidence from medium-sized emerging Asian countries, this study examined intra-industry peer effects, i.e., imitation, on debt financing at Thai listed companies. The sample consisting of the firms listed on the Stock Exchange of Thailand (SET) during the years 2001–2018 was incorporated to discover those effects. Numerous databases associated with the SET (e.g., SETSMART) and the firms’ websites were used to collect financial numbers. With 6,058 firm-year observations, unbalanced panel data was then analyzed by using the random-effects and fixed-effects ordinary least squares models as well as the two-stage least squares regression. The main findings show that a focal firm imitates the long-term debt financing of its industry peers. Using the instrument approach to address endogeneity, the key results are confirmed. Peers’ equity shock as the instrumental variable decreases their financing with debt, subsequently lowering debt levels at a focal firm. This mimicking was operated through peer action, not peer character, i.e., performance. In additional tests, severe market competition was found to strengthen the uniformity of decision-making on debt finance among industry peers. Meanwhile, the high cost of information embedded in innovation-driven businesses has not been found to both promote and reduce peer effects on debt finance. Including the extra control variables at firm-specific levels, the key results remain robust. This study highlights a vein of social learning theory and competition-based theory in discussing herding behaviors toward all member firms in a certain industry. The conclusions enrich the literature on peer effects on debt finance policy.
Attributes of Business Administration Graduates from Stakeholder Perspectives: Case Study of Prince of Songkla University, Pattani Campus
Authors: Wesarat Phathara-on , Benrit Parichard , Panrod Warrapojn , Tongsamsi Kanyaprin , Useng Nursahida , Tansui Daranat , Sangkhaduang Ranchida , Kaewsaeng-on Rudsada
Published: May 2024

Unemployment of new graduates remains because of a mismatch between employer demands and graduate attributes. To reduce the skills gap, the study programs need to know what attributes are required by stakeholders. This study aims to identify the attributes of business administration graduates based on the requirements of stakeholders, and to determine the importance of the attributes of business administration graduates. The qualitative data was collected from stakeholders consisting of 17 internal stakeholders and 29 external stakeholders. Based on qualitative data analysis approach, the data was analyzed and thematically categorized by researchers. The study found that the importances of both generic and specific attributes of graduates were mentioned by stakeholders. The attributes of business administration graduates include 36 generic attributes and 3 specific attributes. This study suggested that the study programs should integrate the attributes of graduates into curriculum design and provide students with teaching and learning activities that enable them to develop the expected attributes. However, this study investigated graduate attributes specifically for the Bachelor of Business Administration Program, Faculty of Humanities and Social Sciences, Prince of Songkla University, Pattani Campus. The results of the study may not be generalized to other programs of study or other areas because the required graduate attributes in a specific area can be different than others.
The Influence Of Financial Literacy On The Effectiveness Of Village Fund Management In Tompobulu District, Gowa Regency
Authors: Vira Prithy Fani  , Nasrullah Nasrullah , Abd. Khaliq
Published: May 2024

This research is a type of quantitative research with the aim of determining the influence of financial literacy on the effectiveness of village fund management in Tompobulu District, Gowa Regency. The type of data used is quantitative analysis with data collection through observation and questionnaires using data collection techniques: validity and reliability tests, classical assumption tests and simple regression analysis. The research results that can be written show that financial literacy for the t count of 6,489 is greater than the t table of 1,691 (6,489 > 1,691) has a significant effect on the effectiveness of village fund management. Based on the results of research conducted at the data collection, data management and data analysis stages regarding the influence of financial literacy on the effectiveness of village fund management in Tompobulu District, Gowa Regency, it can be concluded that financial literacy has a positive and significant effect on the effectiveness of village fund management in Tompobulu District, Gowa Regency.
Isolation and Identification of Coliform Bacteria from the Drinking Water of the Shah Abdul Latif University Khairpur
Authors: Talpur Mir Muhammad Ali , Katohar Imdadullah , Mughal Amjad Ali , Samejo Zuhaib Ahmed , Khoharo Saadullah
Published: May 2024

Contamination of drinking water in a developing countries is mostly due to the lack of awareness of the risks, and inadequate training of personnel and management working on drinking water systems. This usually results in avoidable disease outbreaks. A study was carried out to isolate and identify coliform bacteria in the drinking water of Shah Abdul Latif University, Campus, Khairpur (Mir’s) Sindh, Pakistan. Several water samples from different sites of the University were collected and analyzed for coliform bacteria. E.coli was used as an indicator organism, and various types of coliform bacteria were detected. Most of the samples isolated from the campus were contaminated with multiple bacteria. The main water supply of the university showed contamination with E.coli, Salmonella, Enterobacter, Shigella, and Neisseria. The most common microorganism found in water samples was E coli. It is recommended that efforts should be made to de-contaminatethe water supply of the university which might result in catastrophic outbreaks of the disease if the water supply remains contaminated.
Photo-catalytic Degradation of Ciprofloxacin using Manganese and Cobalt Co-Doped Titanium Dioxide Nanoparticles (Mn-Co-TiO2)
Authors: Tasleem Fouzia , Khan Mansoor , Khan Aziz Ahmed , Imran Muhammad , Sabir Nadim
Published: May 2024

The presence of Ciprofloxacin (CIP) in wastewater sources is a major concern for the health of the aquatic system and the soil environment. Several attempts have been made for Ciprofloxacin detection in wastewater. This study reports the synthesis of a new catalyst called 'Manganese and Cobalt codoped titanium dioxide (Mn-Co-TiO2) nanoparticles' for photocatalytic degradation of ciprofloxacin. Mn-Co-TiO2 nanoparticles were synthesized using the sol-gel method. The nanoparticles were characterized using Fourier Transform Infra-Red spectroscopy for a functional group, Scanning Electron Microscopy for surface morphology, and X-Ray diffraction analysis for crystallinity. Various parameters such as solution pH, ultraviolet (UV) light exposure time, and initial drug concentrations were optimized for quantitative percent degradation. Moreover, the limit of detection (LOD) and limit of quantification (LOQ) were also calculated under optimized experimental conditions. The kinetic data show that the degradation of CIP by Mn-Co-TiO2 follows pseudo-first-order kinetics. The proposed method was successfully applied to commercial formulations like Cipro, Cipro XR, and ProQuin XR with satisfied addiction recovery results.
Enhancing Oral Solubility and Permeability of Edoxaban Tosylate Via Development of Self-microemulsifying Drug Delivery System
Authors: Azad Syeda Aneela , Ilyas Umair , Altaf Reem , Saleem Kalsoom , Gul Shaista
Published: May 2024

Edoxaban tosylate monohydrate (EDTM) is present in class IV of the biopharmaceutics classification system (BCS), as it is poorly soluble and poorly permeable, which limits its bioavailability. The rationale of this study was to improve the permeability and solubility of EDTM by incorporating it into a self-micro-emulsifying drug delivery system (SMEDDS).  Suitable excipients were selected and evaluated for their compatibility. The solubility of EDTM was evaluated for all excipients (oil, surfactant, and co-surfactants) at different ratios. Olive oil, Kolliphor RH40, and PEG-400 were chosen as the oil, surfactant, and co-surfactants, respectively, and were developed into a SMEDDS by adding 15 mg of EDTM. The optimized EDTM-SMEDDS (F1, F2, F3, and F4) were characterized for particle size, polydispersity index (PDI), zeta potential, stability, in vitro release, and ex vivo permeation studies. F2 showed a particle size of 56.43 ± 1.78, PDI of 0.190 and -3.30 ± 0.56 mV of zeta-potential. The enhanced release and permeability of F2 were observed for all other EDTM-SMEDDSs and raw EDTM dispersions. Upon storage under continuous temperature and accelerated stability conditions, F2 showed no signs of phase separation and was visually clear while retaining the %encapsulation efficiency and drug loading, that is, it was stable. The liquid EDTM-SMEDDS improved the bioavailability of EDTM.
Development of Self-Nano-Emulsifying Drug Delivery System for Gemcitabine: In Vitro and Ex Vivo Evaluation
Authors: Gul Shaista , Azad Syeda Aneela , Saleem Kalsoom , Ilyas Umair
Published: May 2024

Researchers often aim to develop novel drug delivery systems to overcome the barriers associated with conventional drug delivery systems. Therefore, GEM (Gemcitabine), an anti-cancerous drug, belonging to the Biopharmaceutics Classification System (BCS) Class III with reduced permeability, is an important challenge. Self-nano-emulsifying drug delivery system (SNEDDS) was opted to be designed in such a way that it improves the permeability of GEM. From compatibility and solubility studies, Kolliphor RH40, castor oil, and polyethylene glycol-400 were chosen in optimized ratios for preparation into GEM-SNEDDS. GEM-SNEDDS F3 showed -12.1±6.83 mV zeta-potential, 0.406 PDI, and 94.81±82.73 nm particle size when tested for in vitro and ex vivo studies, F3 showed improved GEM release in simulated gastric fluid and simulated intestinal fluid in vitro and enhanced permeability ex vivo. These factors are prerequisites for the improvement of poor bioavailability of GEM. From stability studies, it was evident that F3 retained its physical stability at several stability conditions and in drug encapsulation and loading. Hence, we developed GEM-SNEDDS as a novel drug delivery system for increasing the permeability and, in turn, the oral bioavailability of GEM.
Genetic Polymorphisms in GABRD and Treatment Response and Dose in Methadone Maintenance Treatment
Authors: Editorial Staff
Published: May 2024

Xie and colleagues studied the association between the genetic polymorphs of the GABA receptor delta subunit (GABARD) and dose-response to methadone in heroin addicts subjected to methadone maintenance therapy (MMT) was studied. They investigated two groups: responders and non-responders were created from a total of 286 recruited MMT patients where the parameter for classification was retention time in therapy. According to stabilized methadone dose, 177 patients were divided into subgroups of high dose and low dose. TaqMan SNP assay was used for GABRD genotyping and the following single nucleotide polymorphisms (SNPs) were identified rs2376805 rs13303344, rs2229110, and rs4481796. MMT treatment response and dose showed no significant association with the SNPs whereas the ACGC haplotype for the 4 SNPs varied slightly between the non-responder and responder groups. They concluded that genetic polymorphs of the GABARD do not play a major role in effecting treatment response to methadone Per Med. 2021 Sep;18(5):423-430.
Novel Genetic Variants Associated With Cardiovascular Events in Clopidogrel and Aspirin Users
Authors: Editorial Staff
Published: May 2024

Despite reports showing the effects of genetic variations on major adverse cardiovascular events in individuals suffering from acute coronary syndrome (ACS) and in patients undergoing percutaneous coronary intervention (PCI), the data, studied until now, covers only a minute fraction of the genetic variations of the human genome.  Using two-stage large-scale sequencing data which consists of high-depth exome sequencing of 168 patients in the discovery cohort and 1793 patients of the replication cohort being subjected to high-depth targeted sequencing, Lie and colleagues discovered novel variants that show associations with major cardiovascular events in a 1.5 year-long follow-up. MYOM2 (rs17064642), ECHS1 (rs140410716), AGAP3 (rs75750968), WDR24 (rs11640115), EFR3A (rs4736529), NECAB1 (rs74569896), ZDHHC3 (rs3749187), and KRTAP10-4 (rs201441480) were the 8 novel genotypes that we found to bear associations with major cardiovascular adverse effects in patients with ACS. MYOM2 and ECHS1, interestingly, were downregulated both in human and animal models with adverse effect-related phenotypes. With AUC ranges between 0.92 and 0.94 for three machine-learning methods, Liu and colleagues were able to develop a superior classifier for predicting these adverse events over a period of 18 months. Their findings bring focus to predicting cardiovascular adverse outcomes and can aid clinicians in optimizing pharmacological intervention while treating patients suffering from ACS. Pharmacogenomics J. 2021 Dec;21(6):664-672.
MTHFR Gene Polymorphisms and Response to Chemotherapy in Metastatic Colorectal Cancer
Authors: Editorial Staff
Published: May 2024

Ramos-Esquivel and colleagues investigated the association between the first-line fluoropyrimidine-based chemotherapy being administered to patients diagnosed with metastatic colorectal adenocarcinoma and C677T, A1298C single nucleotide polymorphisms (SNPs) of the enzyme methylenetetrahydrofolate reductase (MTHFR). Between January 2019 and November 2020, 68 individuals admitted to San Juan de Dios Hospital in Jose, Costa Rica were subjected to a prospective follow-up. Capecitabine/5-fluorouracil was co-administered with oxaliplatin/irinotecan. Their findings reveal that patients that were homozygotes for the wild-type allele demonstrated a poorer overall response rate as compared to those that possessed one or both MTHFR677T T alleles. MTHFR A1298C genotypes and overall response exhibited no association. Patients with progression-free survival did not contain the MTHFR 677 TT and CT genotypes compared to CC individuals. These conclusions continued to hold post adjustment of confounding factors. A hazard ratio: 1.35; 95% CI, 0.72–2.55; P = 0.34 showed no association between progression-free survival and the MTHFR A1298C SNP. Moreover, no SNP was associated with overall survival. The authors conclude that MTHFR C677T SNP homozygotes and heterozygotes had a better overall response and longer progression-free survival than patients that were homozygous for the wildtype allele. Pharmacogenet Genomics. 2021 Dec 1;31(9):191-199.
Genetic Variations and Drug-Induced Liver Injury in Patients on Simvastatin
Authors: Riaz Muhammad Naeem , Salar Rehan Ullah , Rehman Halim Ur , Noor Sadia
Published: May 2024

Drug-induced liver injury, or DILI, is a primary reason for heart failure.  Uridine diphosphate glucuronosyltransferase 1-1 encoded by the UDP glucuronosyltransferase family 1-member A1 gene (UGT1A1) helps prevent DILI by taking part in reactions that conjugate glucuronic acid with bilirubin. UGT1A1 variations are reported to be linked with DILI.  In this study, we investigated the association between genetic variations in UGT1A1 and hepatic adverse effects in patients treated with simvastatin.  Our results show that rs4148325 is not significantly associated with elevated bilirubin levels.  Therefore, our study suggests that genotypic variations in the UGT1A1 gene may be responsible for simvastatin-related increases in bilirubin levels in our patient cohort.  We conclude that genotyping patients on simvastatin for variations in the UGT1A1 gene may not help predict whether these patients are more likely to suffer from liver injury and consequently can change the drug or dose of the drug.
Resistance of Breast Cancer Cells to Paclitaxel Elucidated
Authors: Editorial Staff
Published: May 2024

The effects of the gene SHOC2 in breast cancer patients and how it is regulated by the long noncoding RNA (lncRNA) MALAT1 were studied to elucidate the potential resistance mechanism to chemotherapy. Breast cancer cells were conferred resistance to Paclitaxel via titrating the cells with increasing doses of the drug. For predicting MALAT1 miRNA regulation, bioinformatic tools were used. It was observed that Paclitaxel resistance in the breast cancer cells was liked to an elevated expression of SHOC2 and MALAT1. They found that MALAT1 confers the Paclitaxel resistance by sequestering miR-497-5p to exaggerate the expression of SHOC1. Increased expression of SHOC2 and MALAT1 in breast cancer has demonstrated poorer therapeutic outcomes of Paclitaxel. They concluded that inhibition of MALAT1 and SHOC2 will lead to up-regulation of miR-497-5p, improving response to Paclitaxel in breast cancer patients. Pharmacogenomics. (2022) DOI: 10.2217/pgs-2022-0077.