bluuebunny/crossref_metadata_2025 huggingface dataset:
Gene locus polymorphisms and expression levels of interleukin-1 in lumbar disc disease: a meta-analysis and immunohistochemical study
Authors: Jiang Hua , Xiao Qianyi , Zhang Ruijun , Wang Jiaqi , Meng Dihua , Zhan Xinli , Wei Qingjun
Published: April 2020

Background

To investigate the association between interleukin (IL)-1α (rs1800587), IL-1β (rs1143634) and IL-1RN variable number tandem repeat (VNTR) polymorphisms, expression levels and lumbar disc disease (LDD).

Methods

All relevant articles were searched from 4 databases including PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI). Odds ratios (OR) with 95% conﬁdence intervals (CI) were calculated to evaluate the association between IL-1 gene locus polymorphisms (rs1800587 in IL-1α, rs1143634 in IL-1β, VNTR in IL-1RN) and LDD susceptibility. Statistical analysis was conducted by Review Manager (Revman) 5.31 software. Furthermore, qRT-PCR and immunohistochemistry (IHC) were performed to evaluate IL-1α, IL-1β and IL-1RN expressions in the normal and degenerated disc.

Results

A total of 15 case-control studies (1455 cases and 2362 controls) were included in our meta-analysis. The pooled results suggested that IL-1α rs1800587 polymorphism was associated with an increased risk of LDD in overall population (T vs. C, OR=1.21, 95%CI=1.04-1.40, P=0.01). The subgroup analysis found a significant association between IL-1β rs1143634 polymorphism and LDD in Asian population (T vs. C, OR=0.61, 95%CI=0.39-0.96, P=0.03). Results of qRT-PCR and IHC demonstrated that expressions of IL-1α and IL-1-β were significantly increased in the degenerated disc. (all P<0.05)

Conclusion

IL-1α rs1800587 and IL-1β rs1143634 polymorphisms were significantly associated with LDD in overall population and in Asian population, respectively. The increased expression levels of IL-1α and IL-1β may be the important risk factors for LDD.
The effect of miR-23b-3p on growth hormone in pituitary cells of Yanbian yellow cattle
Authors: Ji Jiuxiu , Lou Angang , Zhang Rui , Jin Taihua , Xiang Siyu , Cui Changyan , Yu Longzheng , guan lizeng
Published: April 2020

Background There is a relationship between miR-23b-3p and GH in pituitary of Yanbian yellow cattle. However, the specific mechanism of the effect of miR-23b-3p on GH in pituitary of Yanbian yellow cattle is still unclear.This study aimed to evaluate the effect of miR-23b-3p on growth hormone (GH) in pituitary cells of Yanbian yellow cattle. Methods The primary culture of Yanbian yellow cattle pituitary cells was carried out, and mimics (miR-23b-3p-mi group), mimics reference substance (NC group), inhibitor (miR-23b-3p-in group) and inhibitor reference substance (iNC group) of miR-23b-3p were transfected into the established pituitary primary cells. After 48 h, the cells were collected and the total RNA and protein were extracted.The mRNA transcription and protein expression level of GH and miR-23b-3p target genes were detected by real time fluorescence quantitative PCR (qPCR) and Western blot, respectively. The target relationship of miR-23b-3p was validated by double luciferase reporter gene system. Results Compared with the NC control group, GH mRNA transcription and protein expression level in pituitary cells of Yanbian yellow cattle was significantly decreased by adding miR-23b-3p minics ( P <0.01), while compared with the iNC control group, GH mRNA transcription and protein expression level were significantly increased by adding miR-23b-3p inhibitor( P <0.05). The result of bioinformatics analysis and double luciferase reporter gene system validation proved that miR-23b-3p targeted 3'UTR of pituitary specific transcription factor 1 (POU1F1). Compared with the NC control group, POU1F1 mRNA transcription and protein expression level were significantly inhibited by the addition of miR-23b-3p minics ( P <0.01), while compared with the iNC control group, POU1F1 mRNA transcription and protein expression level were significantly increased by the addition of miR-23b-3p inhibitor ( P <0.01). Conclusions miR-23b-3p could regulate GH in pituitary cells by regulating POU1F1 gene.
Clinical value of oblique lateral lumbar interbody fusion combined with posterior navigation and long segment internal fixation in the treatment of degenerative scoliosis
Authors: Lou Yuliang , Fei Hui , Hong Feng , Wang Canfeng , Quan Renfu
Published: April 2020

Background ：To assess the short-term clinical outcomes of oblique lateral lumbar interbody fusion (OLIF) combined with multiple level fixation with the guidance of posterior "O" arm CT navigation for degenerative scoliosis. Methods ：A total of 15 patients (3 males and 12 females; average age: 62.2±5.3 years) with degenerative scoliosis were enrolled in our study. All patients were treated with OLIF combined with posterior "O" arm CT navigation and long segment (T 10 -L 5 ) internal fixation during Apr. 2016 and Dec. 2017. Collected perioperative data included surgery time, blood loss, excellent rate of intraoperative pedicle screw. Coronal Cobb angle, lumbar lordosis (LL), intervertebral space height, sagittal balance (SVA) were measured by plain radiograph. Accuracy of pedicle screw placement and intervertebral fusion was investigated with postoperative CT. Visual analogue scale (VAS) and Oswestry disability index (ODI) were used to evaluate the clinical efficacy of surgery. Results ： All patients were followed for 12-25 months (16.5±5.3 months).The OLIF operation time was (98.7±16.8) min, and the blood loss was (50.2±10.7) ml. The posterior "O" arm CT-navigated long segment internal fixation was (101.5 ± 23.4) min, and the blood loss was (63.1 ± 19.7) ml. The total operation time was (200.2±40.2) min, and the blood loss was (113.3±30.4) ml. Coronal Cobb angle, LL, intervertebral space height, SVA, VAS, ODI at the last follow-up were 5.5°± 3.1°, 39.3°± 9.1°, (10.9±1.2) mm, (25.1±10.9) mm, (1.3± 0.8)and(15.8±4.5)%, respectively, showing statistically significant differences ( P <0.05). The "O" arm CT navigation has 240 nails, and the excellent rate of three-dimensional scanning of the "O" arm during surgery is 96%. Lumbar CT showed lumbar fusion at the 6-month postoperative period. Conclusion ： The short-term clinical outcomes of oblique lateral lumbar interbody fusion combined with posterior "O" arm CT-navigated long segment internal fixation for degenerative scoliosis are satisfactory, with advantages like minimal invasiveness, accurate navigation, high bone fusion rate and few complications. Keywords ：Scoliosis; Surgery,computer-assisted; Spine fusion
Molecular Imaging in the selection and evaluation of response in patients treated with Radium-223 in six different solid tumors: A single center experience
Authors: MEDINA-ORNELAS SEVASTIAN , GARCIA-PEREZ FRANCISCO OSVALDO , Alvarez-Avitia MIGUEL , SOBREVILLA-MORENO NORA , SANTANA-RIOS ZAEL , GARCIA-ORTEGA DORIAN , BARRON-BARRON FELICIANO , ARRIETA-RODRIGUEZ OSCAR
Published: April 2020

Objective: Evaluate impact after 223 Ra therapy and 18 F-NaF (sodium fluoride) PET/CT in the selection and evaluation of response in patients treated with 223 Ra in six different solid tumors. Material and Methods: Twenty patients with metastatic castration-resistant prostate cancer (mCRPC), seven metastatic castration-sensitive prostate cancer (mCSPC), three osteosarcoma, two breast cancer, two non-small cell lung cancer (NSCLC), one chondrosarcoma, one chordoma and one patient lung neuroendocrine carcinoma. Three groups of study were defined according total skeletal tumor-burden obtained by 18 F-NaF PET/CT, group 1 <1000cm 3 , group 2 1001–2999cm 3 and group 3 >3000cm 3 VOI´s. A semi-quantitative comparison was performed measuring the SUVmax values of VOIs values in all bone metastases in each patient previous to receive the first cycle of 223 Ra, after 3 and 6 cycles. Results: 30 patients non-progress disease was documented after 24±4 weeks. 8 patients progress disease was presented after three cycles of 223 Ra, two patients with osteosarcoma, four patients with mCRPC, one patient with chondrosarcoma and one patient with NSCLC. Group 1 patients showed better response rates compared to group 3 (p<0.05). Group 2 patients who showed improvement clinical and radiological, had prostate malignancies compared to those in the same group, but non-prostatic malignancies (p<0.05). No significant difference in group 2 patients compared to group 3 (p<0.67). Symptomatic skeletal-related event was observed in 7 patients. Conclusion: 18 F-NaF PET/CT allows to identify patients who show osteoblastic bone activity and discard or confirm progression in the interval PET/CT image, allowing change of treatment, reducing costs. High tumor-burden strongly suggests a poor response to treatment
Synergic effect of diabetes mellitus and H. pylori infection on proliferation of cells via downregulating the expression of PTEN by hypermethylating its promoter region
Authors: Lu Huibin , Han Xinwei , Ren Jianzhuang , Ren Kewei , Li Zongming , Zhang Quanhui
Published: April 2020

Background It has been reported that CagA of H. pylori reduced the expression of PTEN by enhancing its promoter methylation. Furthermore, DM may also promote the methylation status of PTEN, a tumor suppressor gene in Gastric cancer. It is intriguing to explore whether DM may strengthen the tumorigenic effect of HP by promoting the methylation of PTEN promoter and whether the administration of metformin may reduce the risk of GC by suppressing the methylation of PTEN promoter. Methods Bisulfite sequencing PCR was performed to measure the DNA methylation of PTEN promoter in GC patients and HGC-27 cells treated under different conditions. Quantitative real-time PCR was carried out to measure the expression of PTEN mRNA. Immunohistochemistry and Western blot were used to evaluate the expression of PTEN protein. Immunofluorescence and flow cytometry were performed to analyze the apoptosis of GC tissue samples and HGC-27 cells treated under different conditions. MTT assay was carried out to examine the proliferation of HGC-27 cells. Results DNA methylation of PTEN promoter was synergetic enhanced by HP infection and Diabetes mellitus in patients with Gastric cancer. Accordingly, the expression of PTEN was suppressed in GC patients with HP infection and DM. Furthermore, cell apoptosis was decreased in GC patients with HP infection and DM. Metformin showed an apparent effect on maintaining CagA induced elevation of PTEN promoter methylation, thus attenuating the PTEN expression, increasing the proliferation and suppressing the apoptosis of HGC-27 cells. Conclusion In this study, we collected GC tumor tissues from GC patients with or without DM/HP to compare their PTEN methylation and expression while testing the effect of Metformin on the methylation of PTEN promoter. Our study provided evidence for the mechanism underlying the therapeutic role of Metformin in GC treatment.
Barriers to recruitment into a multi-site randomized controlled trial comparing the effectiveness of specialty outpatient versus nurse-led telephonic palliative care of older adults with advanced illness
Authors: Brickey Julia A , Cho Jeanne , Flannery Mara , Grudzen Corita R. , Investigators EMPallA
Published: April 2020

Background Emergency department (ED) visits among older adults are common near the end of life. Palliative care has been shown to reduce ED visits and to increase quality of life among patients, but recruitment into these programs is often challenging. Methods A multi-site randomized controlled trial investigating two modes of community-based palliative care delivery for patients in the ED who are discharged home. Research coordinators monitored factors that prevented eligibility and enrollment by screening electronic health records to identify and recruit eligible patients and their caregivers. Reasons for ineligibility and non-participation were documented. Results Among the 7,091 patients who met the age and disease qualifier, 4,292 (60.5%) were deemed ineligible due to hospital admission. Additional reasons for ineligibility included previous palliative care (919 [13%]) or residence in a nursing facility (462 [6.5%]). Of the 695 patients who were eligible, 298 were enrolled, yielding an enrollment rate of 43% (range of 9% to 80% across all sites). Of the 397 eligible patients who did not participate, 180 (45.3%) refused due to barriers related to illness severity. Patients commonly refused due to misconceptions/stigma related to palliative care (118 [29.7%]). One-hundred fifteen patients (29%) refused due to the mode of palliative care delivery. Conclusions Hospital admission from the ED proved to be the most significant barrier to eligibility. Eligible patients often refused participation due to the nature of their illness, misconceptions about palliative care, and concerns about being able to attend clinic visits if assigned to the outpatient arm.
Chemical Profiling of Wen-Dan Decoction by UPLC/Q-TOF-MS/MS and Variation Analysis between Different Processes Based on Chemometric
Authors: Gao Ximei , Luo Zichen , Qiao Ping , Zhang Wen , Zhao Xiaoli , Di Liuqing , Chi Yumei
Published: April 2020

Background: Wen-Dan decoction (WDD) is a traditional Chinese medical prescription composed of six herbs for the treatment of neurological diseases. The research of classic prescription (CP) is the hotspot in China which aims to develop the ancient and highly effective prescriptions into modern formulations under the condition of ancient dosage. In order to clarify the effects of ancient and modern techniques on WDD in the research of CP, the compounds in WDD should be systematically studied first, and the issue whether there are significant differences on components even efficacy between different preparation processes has to be explored.Methods: In this study, ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was employed to analyze the components of WDD rapidly in both positive and negative ion mode. The analysis methods of chemometric, such as partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA), was innovatively adopted to compare three typical processes (ancient decoction process, modern decoction process and modern alcohol precipitation process).Results: The 121 compounds were identified in WDD, including 23 organic acids, 69 flavonoids, 4 amino acids, 5 phenylpropanoids, 6 triterpenoid saponins and 14 other components, and most of them were from Zhishi (Immature orange fruit), Chenpi (Dried tangerine peel) and Gancao (Liquorice root). Additionally, significant differences between three processes were proved in this study, and 24 components were considered to be related to the differences between ancient and modern technology, as well as 18 compounds could be affected in the process of alcohol precipitation. The relative content of compounds in modern decoction process was higher than that in ancient decoction process, indicating the extraction efficiency of modern technology was greater than that of ancient process. Conclusion: The chemical profiling of WDD provided the bases for the study of active components and quality control. The obvious differences among three processes suggested that the content of active ingredients in the study of CP should be strictly controlled to ensure the transfer of significant efficacy from ancient prescriptions to modern formulations.
Chest CT imaging of pediatric COVID-19 infection: a case report
Authors: Xu Huayan , Hou Keke , Zhang Na , Yang Ming , Guo Yingkun
Published: April 2020

Background: Coronavirus Disease 2019 (COVID-19) outbreak in Wuhan, China spreading rapidly worldwide. Over 100 countries have reported surpassing 100,000 laboratory-confirmed cases of COVID- 19, and in which 2.1% were under aged 19 years. However, little is known about the imaging features about pediatric COVID-19 patients. Herein, we report two cases about COVID-19 involving the clinical data as well as chest images.Case presentation: Two pediatric patients admitted to hospital because of high fever or dry cough. Both children had been recent exposure to the COVID-19 confirmed patients of their family members. Real-time polymerase chain reaction(RT-PCR) test of these two patients’ sputum were positive for SARS-CoV-2 nucleic acid, and diagnosed as COVID-19 infection. Laboratory tests indicate normal white cell count (5.02 x10^9/L) and neutrophils (40.8%) in one case, and slightly increased white cell count (11.86 x10^9/L) and normal neutrophils (16.1%)in the other one. CRP of both cases were within the normal range. Computed tomography (CT) was used to evaluate the novel coronavirus pneumonia (NCP) of these two pediatric patients. Small nodule was found in the upper right lobe of one case; and bilateral peripheral ground-glass opacities were observed in the other patient.Conclusion: In summary, clinical symptoms and signs, laboratory tests and chest CT images of pediatric patients were untypical. Epidemic exposure history and RT-PCR results still play an important role in the precise diagnosis of COVID-19 children.
Особенности релаксации остаточной намагниченности антиферромагнитных наночастиц на примере ферригидрита
Authors: Балаев Д.А. , Красиков А.А. , Балаев А.Д. , Столяр С.В. , Ладыгина В.П. , Исхаков Р.С.
Published: April 2020

In this work, we studied the relaxation of the remanent magnetization of antiferromagnetically ordered ferrihydrite nanoparticles under the conditions of realization of the exchange bias effect for these systems. Magnetization relaxation is characterized by a logarithmic dependence on time, which is typical for thermo-activation processes of the hopping of the magnetic moment of particles through potential barriers caused by magnetic anisotropy. The energy of the barriers obtained from processing the data on relaxation of the remanent magnetization (under the conditions of field cooling) significantly exceeds that for ordinary conditions (zero field cooling). The observed difference indicates the possibility of using the residual magnetization relaxation process to analyze the mechanisms responsible for the effect of exchange bias in antiferromagnetic nanoparticles and obtain the parameters characterizing the exchange coupling of magnetic subsystems in such objects.
Влияние термообработки на формирование активных центров меди, полученных путем взаимодействия хлорида меди с H-морденитом
Authors: Срабионян В.В. , Сухарина Г.Б. , Каптелинин С.Ю. , Дурыманов В.А. , Ермакова А.М. , Курзина T.И. , Авакян Л.A. , Бугаев Л.A.
Published: April 2020

The heat treatment effect on the formation of catalytically active copper centers obtained by solid-phase ion exchange between copper chloride and zeolite H-Mordenite was studied using X-ray absorption spectroscopy in the near edge (XANES) and extended (EXAFS) regions beyonds the copper K-edge. The spectra were measured in reaction conditions, at temperatures ranging from room temperature to 400°C. The analysis of the spectra performed by direct calculations of Cu K-XANES and Cu K-EXAFS fitting with account for anharmonic corrections showed that up to 200 ° C ion exchange does not occurs and copper remains in the state of CuCl. The heating above 200 ° C result in implantation of copper atom in zeolite framework.
Рассеяние фононов на парамагнитных ионах европия и самария в феррите висмута
Authors: Митаров Р.Г. , Каллаев С.Н. , Бакмаев А.М. , Резниченко С.А. , Темиров А.Т.
Published: April 2020

The temperature dependence of the thermal diffusivity and thermal conductivity of the multiferroics BiFeO3, Bi0.90Sm0.10FeO3 and Bi0.90Еu0.10FeO3 is studied. It was found that the substitution of bismuth ions by the rare-earth europium and samarium ions in bismuth ferrite leads to a decrease in phonon thermal conductivity in a wide temperature range. It was established that the decrease in the thermal conductivity of bismuth ferrite is due to resonance scattering of phonons at paramagnetic levels of europium and samarium ions.
Пределы "физической детонации" при течении предварительно колебательно-возбужденного водорода в ударной трубе
Authors: Куликов С.В. , Червонная Н.А. , Терновая О.Н.
Published: April 2020

Physical detonation" - - - is a phenomenon when the detonation is caused not by chemical, but by physical energy focused on internal degrees of freedom, in this case on the vibrational degrees of freedom of hydrogen molecules. The Monte-Carlo method of non-stationary statistical simulation has been used to study the possibility of this phenomenon for pre-vibrationally excited hydrogen to a certain temperature in a shock tube. The boundary of this temperature above which "physical detonation" takes place in the numerical experiment is determined.
Динамика подъема скользящей дуги в униполярной лестнице Иакова
Authors: Алмазова К.И. , Белоногов А.Н. , Боровков В.В. , Горелов Е.В. , Дубинов А.Е. , Клюшин Д.С. , Морозов И.В.
Published: April 2020

The authors created a device with a gliding unipolar arc of the Jacob’s ladder type. This paper presents investigation results of the arc ascent dynamics. It was found that the arc motion is uniform on the major part of its way. The arc ascent has the convection nature due to the air heating by the plasma. Dependence of the arc ascent velocity on the apex angle between the electrodes is obtained. The dependence is decreasing.
Численное моделирование процесса получения мультикремния методом направленной кристаллизации
Authors: Смирнов С.А. , Калаев В.В.
Published: April 2020

Numerical simulation of silicon multi-crystal growth by directional solidification with a square crucible is considered. We validate the use of 2D geometry of the vertical cross section as a computational domain. The model describes melt hydrodynamics, global heat transfer, thermal stresses and the evolution of the dislocation density in the crystal. The sensitivity of the stresses and dislocation density in the Si crystal to the parameters of the Alexander-Haazen model is analyzed.
Исследование плазменных колебаний в стеклообразных диэлектриках методом полного внешнего отражения рентгеновских лучей
Authors: Стожаров В.М.
Published: April 2020

Glass-like dielectrics are studied by methods of plasmon dispersion and asymmetry of the number of localized electrons in the zone of formation of the total external reflection of x-rays and the excitation of plasma vibrations. Defined by the internal mechanical stress and the associated polarization of the investigated dielectrics. The absence of internal mechanical stress in a single crystal of lithium fluoride was found out, and the observed polarization is caused by a large macroscopic dipole moment in this single crystal
Usability Methods and Attributes Reported in Usability Studies of Mobile Apps for Health Care Education: Protocol for a Scoping Review (Preprint)
Authors: Johnson Susanne Grødem , Potrebny Thomas , Larun Lillebeth , Ciliska Donna , Olsen Nina Rydland
Published: April 2020

BACKGROUND

E-learning technologies, including mobile apps, are used to a large extent in health care education. Mobile apps can provide extendable learning environments and motivate students for adaptive and collaborative learning outside the classroom context. Developers should design practical, effective, and easy-to-use mobile apps. Usability testing is an important part of app development in order to understand if apps meet the needs of users.

OBJECTIVE

The aim of this study is to perform a scoping review of usability methods and attributes reported in usability studies of mobile apps for health care education.

METHODS

The scoping review is guided by the methodological framework developed by Arksey & O’Malley and further developed by Levac et al and Kahlil et al. The stages we will follow are as follows: (1) identifying the research question; (2) identifying relevant studies; (3) selecting studies; (4) charting the data; and (5) summarizing and reporting the results. We have developed two research questions to meet the aim of the study, which are as follows: (1) What usability methods are used to evaluate the usability of mobile apps for health care education? and (2) What usability attributes are reported in the usability studies of mobile apps for health care education? We will apply a comprehensive search of the literature, including 10 databases, a reference search, and a search for grey literature. Two review authors will independently screen articles for eligibility.

RESULTS

The initial electronic database searches were completed in March 2019. The literature search identified 14,297 unique references. Following title and abstract screening, the full texts of 369 records were obtained. The scoping review is expected to be completed in spring 2021.

CONCLUSIONS

We expect the overview of usability methods and attributes reported in usability studies of mobile apps for health care education to contribute to the knowledge base for researchers and developers. It will give an overview of the research field and provide researchers and developers with relevant and important information on the usability research area, including highlighting possible research gaps.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/19072
Estimation of the Probability of Reinfection With COVID-19 by the Susceptible-Exposed-Infectious-Removed-Undetectable-Susceptible Model (Preprint)
Authors: Victor Okhuese Alexander
Published: April 2020

BACKGROUND

With the sensitivity of the polymerase chain reaction test used to detect the presence of the virus in the human host, the worldwide health community has been able to record a large number of the recovered population.

OBJECTIVE

The aim of this study was to evaluate the probability of reinfection in the recovered class and the model equations, which exhibits the disease-free equilibrium state for the coronavirus disease.

METHODS

The model differential equation was evaluated for the disease-free equilibrium for the case of reinfection as well as the existence and stability criteria for the disease, using the model proportions. This evaluation shows that the criteria for a local or worldwide asymptotic stability with a basic reproductive number (R0=0) were satisfied. Hence, there is a chance of no secondary reinfections from the recovered population, as the rate of incidence of the recovered population vanishes (ie, B=0).

RESULTS

With a total of about 900,000 infected cases worldwide, numerical simulations for this study were carried out to complement the analytical results and investigate the effect that the implementation of quarantine and observation procedures has on the projection of further virus spread.

CONCLUSIONS

As shown by the results, the proportion of the infected population, in the absence of a curative vaccination, will continue to grow worldwide; meanwhile, the recovery rate will continue slowly, which means that the ratio of infection rate to recovery rate will determine the death rate that is recorded. Most significant for this study is the rate of reinfection by the recovered population, which will decline to zero over time as the virus is cleared clinically from the system of the recovered class.
Analisis Pemanfaatan Joule Thief Tipe Toroida Pada Sel Volta Menggunakan Elektroda (Cu(Ag)-Zn) Berbahan Elektrolit
Authors: Pauzi Ahmad Gurum , Wicaksana Bela
Published: April 2020

Pasangan tembaga-seng (Cu-Zn) merupakan pasangan elektroda yang sering digunakan pada sel volta air laut sebagai sumber energi listrik terbarukan. namun, katoda Cu mengalami korosi ketika bereaksi dengan air laut. Oleh karena itu, penelitian ini dilakukan dengan lektroplating Ag pada Cu, namun karena rendahnya intensitas cahaya yang dihasilkan maka pada penelitian ini digunakan joule thief untuk menaikkan besar energi yang ada dalam keluara sel volta. Pada sistem sel volta ini tersusun dari 20 sel dengan elektrolit air laut serta pasangan elektroda Cu(Ag)-Zn. Elektroda antar sel dihubungkan secara seri dengan kabel penghubung dan air laut diganti setiap 24 jam sekali. Pada sistem ini dilakukan pengukuran massa elektroda dan karakteristik elektrik (tegangan, arus, dan intensitas cahaya) selama 72 jam dengan menggunakan joule thief dan tanpa menggunakan joule thief. Hasil penelitian menunjukkan bahwa sel volta yang menggunakan rangkaian joule thief menghasilkan intensitas cahaya 3 kali lebih besar dibandingkan tanpa penggunaan rangkaian joule thief.
XANTHINE OXIDASE INHIBITORY ACTIVITY OF METHANOL EXTRACT FRACTIONS OF VARIOUS INDONESIAN ETHNOPHARMACOLOGICAL PLANTS
Authors: SAKTI ADITYA SINDU , WIDYASTANTO HARNANDA , MAULIDINA ASTRI , MITASARI DIAN , ERIYANI DIYAH SANTI , MUN’IM ABDUL
Published: April 2020

Objective: Hyperuricemia involves an increase in serum uric acid levels, resulting in kidney damage, increased mortality, and reduced quality of life.Inhibitors of xanthine oxidase, which catalyzes the last step in uric acid synthesis, are targets for therapeutic intervention.Methods: An ethnopharmacological approach, screening four native Indonesian herbal medicinal plants with reported activity against hyperuricemia,was used for preliminary studies, fractionating methanolic extracts by solvent partitioning. Fractions were then tested in vitro for xanthine oxidaseinhibitory activity, and the most active fraction was then subjected to preliminary phytochemical screening.Results: The target tissue of the four herbal medicinal plants investigated was Indian bay leaf (Syzygium polyanthum Wight.), God’s crown fruit(Phaleria macrocarpa Boerl.), snake fruit peel (Salacca edulis Reinw.), and Job’s tears tuber (Cyperus rotundus Linn.). Each sample was extracted bymaceration with 80% methanol. The concentrated extract was then fractionated by the liquid-liquid partition method (1:1 v/v) using n-hexane, ethylacetate, butanol, and methanol sequentially as solvents. The results revealed that the ethyl acetate fraction was the most active fraction. S. polyanthumleaf and C. rotundus tuber showed the greatest potential in inhibiting xanthine oxidase, with half-maximal inhibitory concentrations of 18.43 and10.50 μg/ml, respectively. Enzyme kinetics analysis shows that each plant fraction works as a competitive inhibitor of xanthine oxidase.Conclusion: Preliminary screening identified the ethyl acetate fractions of two native Indonesian herbal medicinal plants as showing potential foranti-hyperuricemia activity.
Epilepsia refractaria con convulsiones febriles plus en niños con mutaciones de la subunidad alfa de canales de sodio (SCN1A): un reporte de caso
Authors: Restrepo Daniel Alejandro , Rojas Sara , Lizcano Luis Artuto , Ríos Erika Natalia , Carreño Orlando
Published: April 2020

Se presenta caso de una niña de 10 años con cuadro de epilepsia mioclónica juvenil severa en la infancia, que a los 6 meses de edad debutó con crisis tónico-clónicas generalizadas (TCG) luego de la administración de una dosis de vacuna DPT, con posteriores crisis TCG, mioclónicas y múltiples episodios de estado epiléptico refractarios a fármacos antiepilépticos (FAE) de primera y segunda línea durante los primeros 5 años. Las crisis se asociaron a retraso global en el desarrollo luego del primer episodio. Durante la evolución se realizaron estudios que incluyen resonancia magnética cerebral que fue normal y tomografía por emisión de positrones (PET-CT) que evidenció alteraciones en el metabolismo en región temporal izquierda, además de estudios para inmunodeficiencias y trombofilias sin alteraciones. Los electroencefalogramas iniciales fueron normales, pero video electroencefalograma de 12 horas mostró actividad irritativa en la región central con diseminación bilateral. Los estudios genéticos identificaron una mutación en el marco de lectura de tipo "frameshift" del gen SCN1A mediante secuenciación de la región codificante. Luego de los primeros años de vida, la paciente presenta, atípicamente, remisión progresiva de las crisis con posterior desmonte de FAE y mejoría del neuro-desarrollo en el proceso interdisciplinario de rehabilitación.
Telling Us your Hopes: Ethnographic lessons from a communications for development project in Madagascar
Authors: Kraemer Antonie L.
Published: April 2020

This article discusses ethnographic lessons from a “communications for development” project in Madagascar. Analysing the project’s methodology of participatory oral testimony, the article argues that anthropologists can learn from an explicit focus on empowering informants to become active producers of ethnographic knowledge, and highlights the vital role of communicating joint research findings to influential decision makers. The multiple, differing actor groups united by the project are also assessed, demonstrating how ostensibly incompatible rationalities became creatively translated into mutually acceptable forms, generating unforeseen, new social expression rather than a predictable, universalist development agenda.
Comment: Ethnography under arrest?
Authors: Corsín Jiménez Alberto
Published: April 2020

In this article, Corsín Jiménez comments on the articles of Konopinski, Morreira, and Mateos.
The Lines Between: Relational Subjectivities and the Practice of Observational Drawing
Authors: Taylor Jessica
Published: April 2020

I suggest that language can lock us into rigid and predefined models of relationship, and may prevent versions of ourselves from coming into being. I suggest that in a social context that privileges verbal communication, people with learning disability can be positioned in a discourse of representation depicting them as passive and dependent. Drawing opens a space for non-discursive subjectivities to be explored in the context of relationship. I illustrate these ideas with a vignette of my time spent in a community with adults with learning disability and communication difficulties, whilst also drawing on my experience of working for organisations that support adults with learning disability.
Caste within the Sri Lankan Tamil Diaspora: Ūr Associations and Territorial Belonging
Authors: Paramsothy Thanges
Published: April 2020

This article considers data on London Tamils from Jaffna peninsula, northern Sri Lanka, to examine caste interactions in relation to their efforts to reconnect with people in the diaspora and ‘at home’. The Tamils are part of a substantial number of ūr (home/native place) associations in London and areas outside London. I consider their efforts through changing and unchanging attitudes to caste to recreate a sense of community away from home. They do so by forming associations comprising members of a specific caste group, hailing from a particular village, region, or island in Sri Lanka. I examine the diaspora communities’ understanding of the institution of caste as a wider landscape of belonging. This further considers how caste divisions in the ūr become re-territorialized among the Tamil diaspora. The historical context of these activities relate to the wide dispersal and separation of Tamils from their Sri Lankan homeland during the upheaval of the armed conflict. The article also demonstrates how caste-based relationships and kinship ties shape the lives of members of the Tamil diaspora in London, and how caste-based and fragmented identities operate in such transnational Tamil diaspora localities.
Associação entre a ocorrência de quedas e a hipovitaminose D em idosos.
Authors: Caires Sabrina Da Silva , Souza Adriano Almeida , Santos Lucas Dos , Pinto Lélia Lessa Teixeira , Leal Neto João De Souza , Almeida Cláudio Bispo de , Casotti Cezar Augusto
Published: April 2020

Analisar os fatores associados à ocorrência de quedas em idosos residentes em comunidade. Trata-se de um estudo epidemiológico, transversal, de base populacional. Obtiveram-se informações sociodemográficas, nível de atividade física, funcionalidade, quedas, índice de massa corporal e concentração de vitamina D. Participaram do estudo 289 idosos, tendo a hipovitaminose D associada à ocorrência de quedas. Os achados servem de subsídios para o planejamento de ações, as quais possibilitem melhores condições de saúde à população idosa.
A contribuição dos laudos periciais do assistente social na elaboração das sentenças de processos judiciais do Benefício de Prestação Continuada/Idoso
Authors: Pozatti Lisete Maria , Carlos Sergio Antonio
Published: April 2020

Fundamentando-se na legislação e no trabalho dos assistentes sociais peritos judiciais, estudaram-se os laudos e as sentenças de 79 processos de idosos requerentes do Benefício de Prestação Continuada (BPC), junto ao Tribunal Regional Federal da 4ª Região (TRF4-RS), com sentenças proferidas em 2017. A análise do conteúdo foi realizada com o auxílio do software NVivo12. Identificou-se uma variedade de concepções empregadas na construção do documento pericial e uma efetiva contribuição dos laudos sociais nas sentenças.
Interventions pour favoriser l’activité physique et l’appartenance sociale chez les enfants et les jeunes dans des espaces extérieurs : revue rapide de la littérature
Authors: Wray Alexander , Martin Gina , Ostermeier Emma , Medeiros Alina , Little Malcolm , Reilly Kristen , Gilliland Jason
Published: April 2020

Introduction

La conjugaison d’une augmentation du comportement sédentaire et d’une baisse de la santé mentale globale chez les enfants et les jeunes canadiens dans les dernières décennies est le signe évident que l’on a besoin de recherche appliquée axée sur l’élaboration et l’évaluation d’interventions interdisciplinaires. Les espaces extérieurs offrent des possibilités d’activité physique et d’interactions sociales, ce qui en fait un cadre idéal pour répondre à ces préoccupations essentielles en matière de santé chez les enfants et les jeunes.

Méthodologie

Nous avons procédé à une revue rapide de la littérature évaluée par les pairs (n = 3 096) et de la littérature grise (n = 7) afin de sélectionner les interventions en faveur de l’activité physique et de l’appartenance sociale portant sur les espaces extérieurs et visant les enfants et les jeunes (19 ans ou moins) en Australie et en Nouvelle­Zélande, au Canada, en Europe et aux États­Unis. Nous avons déterminé si les interventions étaient efficaces en analysant la conception de l’étude, les intervalles de confiance et les limites signalées, puis en réalisant une synthèse narrative des interventions efficaces.

Résultats

Nous avons relevé 104 études, dont 70 (67 %) ont été jugées efficaces. Sur l’ensemble, 55 interventions visaient l’activité physique, 10 visaient l’appartenance sociale et 5 visaient les deux. Le jeu (n = 47) et le contact avec la nature (n = 25) étaient les thèmes dominants dans toutes les interventions, la plupart ayant lieu dans une école ou un parc. Nous rendons compte des caractéristiques, des limites et des conséquences de ces interventions.

Conclusion

L’intégration d’éléments naturels et ludiques dans les espaces extérieurs peut être un moyen efficace d’améliorer l’activité physique et l’appartenance sociale. Il y a un besoin considérable de recherches plus spécifiques au Canada. De nouvelles stratégies, comme l’intégration de la technologie des téléphones intelligents dans la conception et l’évaluation de ces interventions, méritent d’être envisagées.
Aperçu - Blessures et intoxications associées à la consommation de méthamphétamine : surveillance sentinelle à l’aide de la plateforme électronique du Système canadien hospitalier d’information et de recherche en prévention des traumatismes (eSCHIRPT), 2011 à 2019
Authors: McFaull Steven R. , Champagne André , Thompson Wendy , Bang Felix
Published: April 2020

Des données sur les consultations à un service des urgences pour des blessures et des intoxications liées à la méthamphétamine entre le 1er avril 2011 et le 9 août 2019 ont été saisies dans 19 sites sentinelles au Canada pour des patients de tous âges. On a recensé au total 1093 cas (97,6/100000 cas de l’eSCHIRPT) (dont 59,4 % de patients de sexe masculin). La proportion d’intoxications était plus élevée chez les femmes que chez les hommes (71 % contre 57,4 %). Les blessures et les intoxications accidentelles étaient en cause dans 14,8 % des consultations à un service des urgences. Les blessures auto­infligées (durant ou à la suite de la consommation de méthamphétamine) étaient à l’origine de 11,4 % des cas. Les circonstances des blessures et les intoxications associées à la méthamphétamine étaient variées : blessures auto­infligées, traumatismes cérébraux liés aux chutes, maladies mentales, activités criminelles et diverses autres situations. Ces facteurs devraient être pris en compte dans la préparation des stratégies de réduction des méfaits.
Evaluation of the environmental security of industrial regions: Evidence from the Kemerovo Oblast
Authors: Radionova E.A. , Slesarenko E.V.
Published: April 2020

Subject. The article studies the technological footprint of mining enterprises on the region's environmental system, especially in the vicinity of their location.
Objectives. The research evaluates the technological footprint of coal mining enterprises on the region's environmental system, substantiates the continuing reporting and statistical monitoring of environmental indicators. We also analyze the ratio of current indicators to thresholds and identify menacing environmental trends.
Methods. The research involves the method of environmental security assessment by pollution and water contamination. We also apply methods of statistical observation, consolidation and grouping of statistical materials, absolute and relative statistical values, analytical and synthetic methods.
Results. The article describes the environmental specifics of the industrially advanced region with the predominance of the mining industry. We conducted the environmental monitoring by air and water contamination and point out the main environmental challenges and disparity of the region's environmental and economic well-being. We captured the correlation of the industrial development level, use of natural resources, environmental situation, finance of natural protection activities and public health. The article presents our recommendations for improving the environmental situation.
Conclusions. The governmental involvement is not enough to eliminate the environmental challenges if there are no effective set of environmental standards in the region. The region's environmental situation cannot be improved if the social and environmental liability of most coal business owners and management is raised. It is necessary to tighten the governmental control and increase the social and environmental liability of industrial enterprises for their operations.
ESTADO DE DIREITO E FRONTEIRAS DE EXCESSOS: CIVIL FORFEITURE AMERICANA E PROPOSTA DE AÇÃO CIVIL PÚBLICA DE EXTINÇÃO DE DOMÍNIO NO BRASIL
Authors: Francisco José Carlos , Skorkowski Denis
Published: April 2020

Partindo do problema relativo à busca de meios para combater a criminalidade expropriando bens, direitos e valores envolvidos com ilícitos, este estudo tem como hipótese a compatibilidade do Projeto de Lei do Senado Federal nº 257/2015 com o sistema jurídico brasileiro, desde que não incida em vícios incorridos pela Civil Forfeiture americana, pretendendo aplicar sanção civil como subterfúgio para evitar garantias penais. Como pressuposto para aplicação do confisco previsto na ação civil pública de extinção de domínio, é necessário comprovar o abuso ao exercício do direito à propriedade (ou descumprimento de sua função social) mediante nexo de causalidade do bem, direito ou valor com atividade criminosa, não bastando mera suspeita ou dúvida, desde que respeitadas as garantias do Estado de Direito (notadamente o devido processo legal, a certificação da culpabilidade de pessoas envolvidas em ilícitos, a individualização da pena e a proteção de lesados e de terceiros de boa-fé). Adotamos o método dedutivo, alternando dissertação e argumentação para expor conceitos e ideias, com levantamento bibliográfico.
ADUBAÇÃO FOLIAR E VIABILIDADE ECONOMICA DE POTÁSSIO NA CULTURA DO TRIGO (Triticum aestiavum L.).
Authors: Alves Donizete Aparecido Da Silva , Welz Caio Cesar , Cruz Rayane Monique Sete da , De Oliveira Karym Mayara , Bonett Lucimar Pereira
Published: April 2020

A disponibilidade do nitrogênio (N) e do potássio (K) e a adequada proporção entre os dois são de grande importância para a realização de processos como crescimento e desenvolvimento das plantas. Este trabalho objetivou avaliar o efeito de fontes e doses de K em associação ao N em cobertura via foliar sobre as características produtivas do trigo (Triticum aestivum L.) cultivado em sistema de semeadura direta, em sucessão à cultura da soja. O experimento foi desenvolvido no ano de 2018 no município de Juranda, região centro oeste do Paraná. O delineamento experimental adotado foi o de blocos casualizados em esquema fatorial 5 x 1, com 6 repetições, totalizando 30 parcelas experimentais, K e KN em combinação, em fase fenológicas diferentes, fase V5 (emborrachamento) e fase R7 (enchimento de grãos). Foram avaliados, tamanho de espiga, quantidade de grão por espiga, e peso de grão, para avaliar os reais benefícios da aplicação da adubação potássica via foliar. Para o número de espigas somente o tratamento com K em enchimento não diferiu do controle, no parâmetro número de grãos obteve-se os melhores resultados em K no emborrachamento e K e N no enchimento, entretanto na massa de mil grãos o K no enchimento obteve a melhor média (40,75 g planta-1) em relação controle. Conclui-se que, a utilização do K via foliar aumenta o comprimento das espiga, número de grãos e massa de mil grãos. Aplicação do produto comercial K-40 no estádio de R7 aumenta em cerca de 30% a produtividade.
Pengaruh Pembiasaan Membaca Al-Qur’an Setiap Pergantian Jam Pelajaran Terhadap Kesiapan Mental Mahasiswa Genta Pare Kediri
Authors: Sofyan Erviana , Hosna Rofiatul
Published: April 2020

This study discusses the effect of quran reading habits on mental readiness, this is motivated by the many students who complain about the lessons learned, it is necessary to have mental readiness when receiving lessons, one of which is to get used to reading the Qur'an. This habituation aims to improve the intelligence of the brain and memory of a person, and can nourish various kinds of physical and psychological illnesses. The purpose of this study is (1) To find out and analyze the habit of reading the Qur'an every turn of the lesson, (2) To find out and analyze mental readiness, (3) To find out and analyze the influence of the habit of reading the Qur'an every turn lesson hours for students' mental readiness in the Golden English Training Area (GENTA) Pare Kediri. In this study, the study design used a quantitative approach with Expost Facto design and used a type of field research. The population in this study were all D1 GENTA Pare students. Sampling in this study used Simple Random Sampling. So that every sample withdrawal using this method provides the same opportunity for each member of the population to be a research sample. In this study, data collection uses a questionnaire that serves to measure the level of mental readiness of students who are influenced by the habit of reading the Qur'an.
Manajemen Tenaga Kependidikan di Madrasah Aliyah
Authors: Hafidzi Dinta , Adistiana Olianda , Thobi’i Fahruruzi Ahmad
Published: April 2020

Education staff management is an activity to manage every individual who is in the Education environment in carrying out their respective duties and functions to run more effectively. The success of school / madrasah-based management is largely determined by its leaders in managing the teaching staff available at school / madrasas. The school principal has responsibility tasks related to the management of the teaching staff which is not an easy task. In addition to striving to achieve the goals of the school but also striving to achieve the goals of educational staff (teachers and employees) in person. From the field of Administration whose role is very important in the world of education. In MAN 3 BANTUL there is an activity that is related to administration which is modern, systematic and makes it easy for all parties. At this school they use a one door service, in which all other information and administrative services become very clear and valid. And this service is placed in the front of the school environment after the entrance gate and in the lobby in order to facilitate and make it a strategic place.