bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 6 from Glutamine Deprivation Enhances Antitumor Activity of 3-Bromopyruvate through the Stabilization of Monocarboxylate Transporter-1
Authors: Cardaci Simone , Rizza Salvatore , Filomeni Giuseppe , Bernardini Roberta , Bertocchi Fabio , Mattei Maurizio , Paci Maurizio , Rotilio Giuseppe , Ciriolo Maria Rosa
Published: March 2023

PDF file - 77K, Glutamine-deprivation up-regulates MCT-1 levels
Supplementary Methods from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

PDF file - 108K
Supplementary Movie 1 from Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI
Authors: Hompland Tord , Ellingsen Christine , Øvrebø Kirsti Marie , Rofstad Einar K.
Published: March 2023

MOV file - 305K, Video showing the outward movement of the peritumoral high-signal-intensity rim of a TS-415 cervical carcinoma xenograft
Supplementary Methods from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: March 2023

PDF file - 120K, Supplementary methods include information on Wnt reporter and beta-Catenin shRNA knockdown constructs, real-time PCR, tumor dissociation, FACS, immunostaining and western blotting
Supplementary Figure Legends from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 109K
Supplementary Figure 7 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: March 2023

PDF file - 867K, Beta-catenin knockdown
Supplementary Figure 3 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 99K, c-Myc activity is decreased in Pten-/Ink4a/Arf-/-mNSCs.
Supplementary Figure 1 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Authors: Young Nathan P. , Crowley Denise , Jacks Tyler
Published: March 2023

Supplementary Figure 1 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Supplementary Table 1 from Lymphatic Reprogramming by Kaposi Sarcoma Herpes Virus Promotes the Oncogenic Activity of the Virus-Encoded G-protein–Coupled Receptor
Authors: Aguilar Berenice , Choi Inho , Choi Dongwon , Chung Hee Kyoung , Lee Sunju , Yoo Jaehyuk , Lee Yong Suk , Maeng Yong Sun , Lee Ha Neul , Park Eunkyung , Kim Kyu Eui , Kim Nam Yoon , Baik Jae Myung , Jung Jae U. , Koh Chester J. , Hong Young-Kwon
Published: March 2023

PDF file - 91K, Regulation of the expression of the RGS genes by KSHV in BECs
Supplementary Figure 4 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: March 2023

PDF file - 3482K, Proliferative activity of 4T1 tumors in vivo. A. Immunofluorescence staining of frozen tumor sections from mice injected with PBS, Gr1+ cells or NEMs using an antibody against PCNA (red); nuclei are counterstained in blue with DAPI. Analysis was performed after the animal sacrifice at day 18 after tumor inoculation. Scale bar: 100 �m. B. Quantitative analysis showing the percentage of PCNA+ nuclei in the tumor sections. Data are mean�s.e.m.; n=5 per group.
Supplementary Figure 1 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: March 2023

PDF file - 251K, (A) Left. C4-HD tumors growing with MPA were untreated or FUL-treated for 48 h and processed for immunohistochemical studies with pER� (Ser167 and Ser118) antibodies. Bar: 60�m. Right. Quantification of positive cells / HPF in untreated or FUL-treated C4-HD tumors. (B) Top. H&E images showing tumor morphology and Ki67 staining after treatment as described in (A). Black arrows show mitotic cells in MPA growing tumors. White arrows show apoptotic cells. Bar: 60�m. Right. Quantification of mitotic or apoptotic cells / HPF in untreated or FUL-treated C4-HD tumors. (C) BCL/XL, BAX and AIF expression after treatment as described in (A). Bar: 60�m.
Supplementary Table 4 from Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages
Authors: Osawa Tsuyoshi , Tsuchida Rika , Muramatsu Masashi , Shimamura Teppei , Wang Feng , Suehiro Jun-ichi , Kanki Yasuharu , Wada Youichiro , Yuasa Yasuhito , Aburatani Hiroyuki , Miyano Satoru , Minami Takashi , Kodama Tatsuhiko , Shibuya Masabumi
Published: March 2023

PDF file - 47K, List of 769 genes down-regulated by JMJD1A siRNA in vivo (c.f. Fig. S20).
Supplementary Figure 1 from TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells
Authors: Weiss Michele B. , Abel Ethan V. , Mayberry Melanie M. , Basile Kevin J. , Berger Adam C. , Aplin Andrew E.
Published: March 2023

PDF file - 3777K, TWIST1 expression is not regulated by RSK, STAT3, AKT, or by protein stability in mutant B-RAF cell lines
Supplementary Figure 2 from The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA
Authors: Rabellino Andrea , Carter Brandon , Konstantinidou Georgia , Wu Shwu-Yuan , Rimessi Alessandro , Byers Lauren A. , Heymach John V. , Girard Luc , Chiang Cheng-Ming , Teruya-Feldstein Julie , Scaglioni Pier Paolo
Published: March 2023

PDF file - 109K
Supplementary Figure Legend from Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury
Authors: Zhan Yu , Chen Po-Ju , Sadler William D. , Wang Fuyuan , Poe Sara , Núñez Gabriel , Eaton Kathryn A. , Chen Grace Y.
Published: March 2023

PDF file - 98K
Supplementary Figure Legends from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: March 2023

PDF file - 60K, Legend for Supplementary Figures S1-S5
Supplementary Methods from Dysregulated Expression of FOXM1 Isoforms Drives Progression of Pancreatic Cancer
Authors: Kong Xiangyu , Li Lei , Li Zhaoshen , Le Xiangdong , Huang Chen , Jia Zhiliang , Cui Jiujie , Huang Suyun , Wang Liwei , Xie Keping
Published: March 2023

PDF file - 77K, Cell scratch-wound assay; Cell migration assay; Cell invasion assay.
Supplementary Tables from A Synthetic Lethality–Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
Authors: Oike Takahiro , Ogiwara Hideaki , Tominaga Yuichi , Ito Kentaro , Ando Osamu , Tsuta Koji , Mizukami Tatsuji , Shimada Yoko , Isomura Hisanori , Komachi Mayumi , Furuta Koh , Watanabe Shun-Ichi , Nakano Takashi , Yokota Jun , Kohno Takashi
Published: March 2023

PDF file, 106K, Supplementary Table S1. BRG1-deficient and -proficient cell lines subjected to BRM knockdown Supplementary Table S2. Verification of gene alterations in cell lines subjected to BRM knockdown Supplementary Table S3. Analysis of missense BRG1 mutations using the Polyphen software Supplementary Table S4. Negative correlation between BRG1 deficiency and alterations in therapeutic target genes in 373 NSCLC cases from three studies (this study and Refs 32 and 33) Supplementary Table S5. Correlation between BRG1 deficiency and smoking in 369 NSCLC cases from three studies (this study and Ref 32 and 33).
Supplementary Table 2 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Authors: Simon Susanne , Grabellus Florian , Ferrera Loretta , Galietta Luis , Schwindenhammer Benjamin , Mühlenberg Thomas , Taeger Georg , Eilers Grant , Treckmann Juergen , Breitenbuecher Frank , Schuler Martin , Taguchi Takahiro , Fletcher Jonathan A. , Bauer Sebastian
Published: March 2023

PDF - 42K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in cell lines.
Supplementary Table 1 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Authors: Simon Susanne , Grabellus Florian , Ferrera Loretta , Galietta Luis , Schwindenhammer Benjamin , Mühlenberg Thomas , Taeger Georg , Eilers Grant , Treckmann Juergen , Breitenbuecher Frank , Schuler Martin , Taguchi Takahiro , Fletcher Jonathan A. , Bauer Sebastian
Published: March 2023

PDF - 41K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in xenografts.
Supplementary Figure 3 from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: March 2023

PDF file - 239K, Figure S3. LJM716 is specific for HER3 and binds a conformational epitope that includes key residues in D2.
Supplementary Table and Figure Legends from A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer
Authors: Deshpande Raamesh , Asiedu Michael K. , Klebig Mitchell , Sutor Shari , Kuzmin Elena , Nelson Justin , Piotrowski Jeff , Ho Shin Seung , Yoshida Minoru , Costanzo Michael , Boone Charles , Wigle Dennis A. , Myers Chad L.
Published: March 2023

PDF file, 59K.
Supplementary Figure 2 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 959K, Representative pictures of tumors obtained in nude mice at end point for each group and data completing Figures 1 and 2.
Supplementary Figure 4 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 152K, Forced expression of PLK1 and TGF-β1 reversed the phenotype created by Mimic transfection in NCI-H446 cells.
Supplementary Table 1 from Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel
Authors: Nieuweboer Annemieke J.M. , Hu Shuiying , Gui Chunshan , Hagenbuch Bruno , Ghobadi Moghaddam-Helmantel Inge M. , Gibson Alice A. , de Bruijn Peter , Mathijssen Ron H.J. , Sparreboom Alex
Published: March 2023

PDF file - 77KB, Plasma pharmacokinetic parameters of paclitaxel (10 mg/kg) in mice using different formulations.
Supplementary Table S5 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

The evaluation of diagnostic performance with the diagnostic probability score (PS).
Supplementary Figure S5 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Figure S5. Reintroduction of WT BRAF in metastatic cell populations.
Supplementary Figure S1 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

A flow chart of study subjects and abbreviations of study groups.
Supplemental Figure S5 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S5. Determination of the specificity of 1A12 in inhibition of HDACs.
Supplementary Figure Legends from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Supplementary Figure Legends
Supplementary Table 2 from High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma
Authors: Udager Aaron M. , Rolland Delphine C.M. , McHugh Jonathan B. , Betz Bryan L. , Murga-Zamalloa Carlos , Carey Thomas E. , Marentette Lawrence J. , Hermsen Mario A. , DuRoss Kathleen E. , Lim Megan S. , Elenitoba-Johnson Kojo S.J. , Brown Noah A.
Published: March 2023

Sinonasal Squamous Cell Carcinoma Clinical and Genotypic Data.
Supplementary Table 1 from High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma
Authors: Udager Aaron M. , Rolland Delphine C.M. , McHugh Jonathan B. , Betz Bryan L. , Murga-Zamalloa Carlos , Carey Thomas E. , Marentette Lawrence J. , Hermsen Mario A. , DuRoss Kathleen E. , Lim Megan S. , Elenitoba-Johnson Kojo S.J. , Brown Noah A.
Published: March 2023

Sinonasal Papilloma Clinical and Genotypic Data.
Supplementary Figures S1-S5 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Figures S1-S5. Quantification of Western blotting bands (S1); LC-MRM analysis of IGF-1R and EGFR tyrosine phosphorylation (S2); Validation of drug effect (S3); Dasatinib-based drug combinations in DDR2-mutant squamous cell lung carcinoma cells (S4); Validation of ligand effects (S5).
Supplementary Figure and Table Legends from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Figure and Table Legends. Legend for Supplementary Figures S1-S5 and Supplementary Tables S1-S5.
Supplementary Table 3 from PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia
Authors: McElwee John L. , Mohanan Sunish , Horibata Sachi , Sams Kelly L. , Anguish Lynne J. , McLean Dalton , Cvitaš Iva , Wakshlag Joseph J. , Coonrod Scott A.
Published: March 2023

Supplementary Table 3: Primers for human quantitative RT-PCR (SYBR)
Supplementary Tables 1 and 2 from CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer
Authors: Karakasheva Tatiana A. , Waldron Todd J. , Eruslanov Evgeniy , Kim Sang-Bae , Lee Ju-Seog , O'Brien Shaun , Hicks Philip D. , Basu Devraj , Singhal Sunil , Malavasi Fabio , Rustgi Anil K.
Published: March 2023

Supplementary Tables 1 and 2. Supplementary Table 1. List of the genes differentially expressed in CD11b+Gr1+ splenocytes from tumor-bearing, compared to control mice. Supplementary Table 2. List of the genes differentially expressed in CD38high, compared to CD38low, CD11b+Gr1+ splenocytes from tumor-bearing mice.
Supplementary Fig 7 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

Treatment of CAL51 cells with AZ3146 and NMS-P715 selected for the same p.S611G and p.Y568C MPS1 mutations.
Supplementary Fig 5 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

Crystal structures of AZD3146 and ONCOII bound to MPS1-KD.
Supplementary Methods from Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
Authors: Kantara Carla , O'Connell Malaney , Sarkar Shubhashish , Moya Stephanie , Ullrich Robert , Singh Pomila
Published: March 2023

PDF file - 133KB
Supplementary Methods and References from Tenascin-C Protects Cancer Stem–like Cells from Immune Surveillance by Arresting T-cell Activation
Authors: Jachetti Elena , Caputo Sara , Mazzoleni Stefania , Brambillasca Chiara Svetlana , Parigi Sara Martina , Grioni Matteo , Piras Ignazio Stefano , Restuccia Umberto , Calcinotto Arianna , Freschi Massimo , Bachi Angela , Galli Rossella , Bellone Matteo
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S7 from NKX3.1 Suppresses TMPRSS2–ERG Gene Rearrangement and Mediates Repair of Androgen Receptor–Induced DNA Damage
Authors: Bowen Cai , Zheng Tian , Gelmann Edward P.
Published: March 2023

Supplementary Figures S1-S7. AR induces chromosome conformational change juxtaposing TMPRSS2 and ERG (S1); TMPRSS2-ERG rearrangement in different NKX3.1-expressing cell lines (S2); NKX3.1 has no effects on TMPRSS2-ERG gene rearrangement in the absence of AR (S3); NKX3.1 expression and TMPRSS2-ERG rearrangement are related to histologic grade (S4); AR and NKX3.1 are recruited to break sites on TMPRSS2 and ERG genes (S5); NKX3.1 facilitates assembly of OGG1 at ERG gene break site (S6); Transcription is not required for TMPRSS2-ERG juxtaposition or rearrangement (S7).
Supplementary Figure S3 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: March 2023

Supplementary Figure S3. (-)-Nutlin-3 and MLN8237 cooperate in p53 induction in vivo.
Supplementary Data Legends from Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Authors: Mansour Nassir M. , Bernal Giovanna M. , Wu Longtao , Crawley Clayton D. , Cahill Kirk E. , Voce David J. , Balyasnikova Irina V. , Zhang Wei , Spretz Ruben , Nunez Luis , Larsen Gustavo F. , Weichselbaum Ralph R. , Yamini Bakhtiar
Published: March 2023

Supplementary Data Legends. Legends for supplementary data presented for publication.
Figure S2 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: March 2023

Supplementary Figure 2
Supplementary Figure S6 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Inhibitory effect of BYL719 on the growth of orthotopic lung tumors of defined Kras or Pik3ca genotype.
Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Authors: Hughes Russell , Qian Bin-Zhi , Rowan Charlotte , Muthana Munitta , Keklikoglou Ioanna , Olson Oakley C. , Tazzyman Simon , Danson Sarah , Addison Christina , Clemons Mark , Gonzalez-Angulo Ana Maria , Joyce Johanna A. , De Palma Michele , Pollard Jeffrey W. , Lewis Claire E.
Published: March 2023

Effects of various cytotoxic agents on TAM accumulation in three mouse tumor models (S1); Further Characterization of MRC1+ TAMs in mouse tumors (S2); VEGFA lmmunofluorescence in control and CTX-treated LLC1 tumors (S3); Role of hypoxic (ie. HIF-expressing) TAMs in relapse of LLC1 tumors after CTX (S4); Effect of CXCR4 blockade on various tumor parameters in CTX-treated LLC1 tumors (S5); Co-localization of HIFs 1 and 2, but not CXCL12 or HO-1, with hypoxia in LLC1s (S6); Effect of CXCR4 blockade on the longer-term re-growth kinetics of primary and metastatic LLC1s (S7).
Supplementary Figure S5 from Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Authors: Taipaleenmäki Hanna , Browne Gillian , Akech Jacqueline , Zustin Jozef , van Wijnen Andre J. , Stein Janet L. , Hesse Eric , Stein Gary S. , Lian Jane B.
Published: March 2023

Supplementary Figure S5. Expression of exogenous miR-135 and miR-203 in orthotopically transplanted breast cancer.
Supplementary figure 3 from Ceacam1L Modulates STAT3 Signaling to Control the Proliferation of Glioblastoma-Initiating Cells
Authors: Kaneko Sadahiro , Nakatani Yuka , Takezaki Tatsuya , Hide Takuichiro , Yamashita Daisuke , Ohtsu Naoki , Ohnishi Takanori , Terasaka Shunsuke , Houkin Kiyohiro , Kondo Toru
Published: March 2023

Supplementary figure 3. The Ceacam1L/STAT3 axis regulated the expression of stemness-related genes in NSCL61s
Supplementary Methods and References from TGFβ Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response
Authors: Han Jianfeng , Chen Xilin , Chu Jianhong , Xu Bo , Meisen Walter H. , Chen Lichao , Zhang Lingling , Zhang Jianying , He Xiaoming , Wang Qi-En , Chiocca E. Antonio , Kaur Balveen , Caligiuri Michael A. , Yu Jianhua
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure 1 from BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
Authors: Alford Sarah E. , Kothari Anisha , Loeff Floris C. , Eichhorn Joshua M. , Sakurikar Nandini , Goselink Henriette M. , Saylors Robert L. , Jedema Inge , Falkenburg J.H. Frederik , Chambers Timothy C.
Published: March 2023

Supplemental Figure 1: Primary ALL cells are highly sensitive to ABT-263
Supplemental Figure S2 from Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat
Published: March 2023

CAIX activity assay.
Supplemental Figure S3 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Figure S3. Comparison of disruptive and truncating p53 classification systems in the training set.
Supplementary Figures 1 - 8 from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
Authors: Vangamudi Bhavatarini , Paul Thomas A. , Shah Parantu K. , Kost-Alimova Maria , Nottebaum Lisa , Shi Xi , Zhan Yanai , Leo Elisabetta , Mahadeshwar Harshad S. , Protopopov Alexei , Futreal Andrew , Tieu Trang N. , Peoples Mike , Heffernan Timothy P. , Marszalek Joseph R. , Toniatti Carlo , Petrocchi Alessia , Verhelle Dominique , Owen Dafydd R. , Draetta Giulio , Jones Philip , Palmer Wylie S. , Sharma Shikhar , Andersen Jannik N.
Published: March 2023

Figure S1. Genomic analysis of SWI/SNF alterations in human cancer. Figure S2. SMARCA4-deficient lung cancer cells depend on SMARCA2 expression for growth. Figure S3. In-situ cell extraction assay for PFI-3 treatment. Figure S4. SMARCA2/4 bromodomain inhibitor does not alter growth of lung cancer cells. Figure S5. Analysis of SMARCA4 target gene expression and promoter occupancy following prolonged treatment with PFI-3. Figure S6. Pharmacological PFI-3 inhibitor studies in leukemia cells. Figure S7. Pharmacological EZH2 inhibitor studies. Figure S8. Genome-wide microarray analysis of SMARCA2 knockdown in A549 cells reconstituted with SMARCA4 cDNAs. Table S1: Survey of genomic lesions in SWI/SNF across different cancer types. Table S2: Sequence information of shRNA's and siRNA's used in the study. Table S3. BROMOScan (DiscoveRx) profiling of PFI-3 (at 2uM) against 32 bromodomains. Table S4. Definition of gene sets (i.e. SMARCA2 knockdown signatures) from SMARCA4 rescue experiments in A549 cells. Table S5. Summary of GSEA normalized enrichment scores (NES) and false discovery rate (FDR) for rescue experiment using ATP-Dead, BRD-Mut and vector control and compared to WT.
Supplementary Table S1 from Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Authors: Wang Jian , Cao Ziquan , Zhang Xing-Mei , Nakamura Masaki , Sun Meili , Hartman Johan , Harris Robert A. , Sun Yuping , Cao Yihai
Published: March 2023

Supplementary Table S1. Clinical data of cancer patients
Supplementary Figure 3 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: March 2023

Supplementary Figure 3-Correlation (corr) of intratumoral FoxP3+ cells and CCL22 levels in CT26 tumors from untreated mice.
Supplementary Figure 2 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: March 2023

Supplementary Figure 2-CpG-induced suppression of Treg infiltration in different mouse tumor models.
Supplemental Tables S1-S3 from VEGF-A Expression Correlates with TP53 Mutations in Non–Small Cell Lung Cancer: Implications for Antiangiogenesis Therapy
Authors: Schwaederlé Maria , Lazar Vladimir , Validire Pierre , Hansson Johan , Lacroix Ludovic , Soria Jean-Charles , Pawitan Yudi , Kurzrock Razelle
Published: March 2023

Supplemental Tables S1-S3. Number/Frequency of mutations in 123 patients with lung cancer (S1); List of genes used in transcriptomic analysis (S2); Expression levels of VEGF-A in mutated (M) vs. wild-type (WT) TP53 lung cancer by histology (S3).
Figure S2 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: March 2023

Figure S2. Core necrosis in B16 melanomas. Representative images of central necrosis of B16 melanoma masses in P2X7R-KO (A and B) or wt (C and D) mice. Specimens were fixed and stained with haematoxylin-eosin as described in Materials and Methods.
Supplementary Figure S2 from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: March 2023

Quantitative analysis of miR-125b levels in enzalutamide-resistant 22Rv1 (22Rv1-EnzR) cells.
Supplemental Figure S2 from Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
Authors: Crompton Joseph G. , Sukumar Madhusudhanan , Roychoudhuri Rahul , Clever David , Gros Alena , Eil Robert L. , Tran Eric , Hanada Ken-ichi , Yu Zhiya , Palmer Douglas C. , Kerkar Sid P. , Michalek Ryan D. , Upham Trevor , Leonardi Anthony , Acquavella Nicolas , Wang Ena , Marincola Francesco M. , Gattinoni Luca , Muranski Pawel , Sundrud Mark S. , Klebanoff Christopher A. , Rosenberg Steven A. , Fearon Douglas T. , Restifo Nicholas P.
Published: March 2023

Supplemental Figure S2. CD8+ tumor-infiltrating lymhphocytes (TIL) isolated from patient with melanoma have reduced phosphorylation of Akt T308 and GSK3βS9 in presence of Akt inhibitor.
Supplementary Figure Legends from Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion
Authors: Wong Sophie Y. , Ulrich Theresa A. , Deleyrolle Loic P. , MacKay Joanna L. , Lin Jung-Ming G. , Martuscello Regina T. , Jundi Musa A. , Reynolds Brent A. , Kumar Sanjay
Published: March 2023

Legends for Supplementary Figures S1-S2.
Supplementary Table S4 from Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Authors: Crowther Andrew J. , Ocasio Jennifer K. , Fang Fang , Meidinger Jessica , Wu Jaclyn , Deal Allison M. , Chang Sha X. , Yuan Hong , Schmid Ralf , Davis Ian , Gershon Timothy R.
Published: March 2023

Control geneses used for transcriptomic analysis.
Supplementary Table S2 from Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Authors: Crowther Andrew J. , Ocasio Jennifer K. , Fang Fang , Meidinger Jessica , Wu Jaclyn , Deal Allison M. , Chang Sha X. , Yuan Hong , Schmid Ralf , Davis Ian , Gershon Timothy R.
Published: March 2023

List of published p53 targets identified by GRO-seq used for transcriptomic analysis.
Supplementary Figure S6 from Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells
Authors: Lerner Robin G. , Grossauer Stefan , Kadkhodaei Banafsheh , Meyers Ian , Sidorov Maxim , Koeck Katharina , Hashizume Rintaro , Ozawa Tomoko , Phillips Joanna J. , Berger Mitchel S. , Nicolaides Theodore , James C. David , Petritsch Claudia K.
Published: March 2023

GBM cell viability and tumor growth after combined PLK1 and MAPK inhibition compared with MAPK inhibition alone.
Supplementary Figure S2 from Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells
Authors: Lerner Robin G. , Grossauer Stefan , Kadkhodaei Banafsheh , Meyers Ian , Sidorov Maxim , Koeck Katharina , Hashizume Rintaro , Ozawa Tomoko , Phillips Joanna J. , Berger Mitchel S. , Nicolaides Theodore , James C. David , Petritsch Claudia K.
Published: March 2023

CD133+ and CD133-/NG2+ subpopulations with distinct viability in GBM cell lines.
Supplementary Figure Legends from Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity
Authors: Shanker Anil , Pellom Samuel T. , Dudimah Duafalia F. , Thounaojam Menaka C. , de Kluyver Rachel L. , Brooks Alan D. , Yagita Hideo , McVicar Daniel W. , Murphy William J. , Longo Dan L. , Sayers Thomas J.
Published: March 2023

Legends for Supplementary Figures S1-S3.
Supplemental Materials and Methods and Legends from MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1
Authors: Lee Jung-Hee , Park Seon-Joo , Jeong Seo-Yeon , Kim Min-Ji , Jun Semo , Lee Hyun-Seo , Chang In-Youb , Lim Sung-Chul , Yoon Sang Pil , Yong Jeongsik , You Ho Jin
Published: March 2023

Supplemental materials and methods and legends for all supplemental figures.
Supplementary Table S5 from CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer
Authors: Yoshida Taku , Kim Jee Hyun , Carver Kristopher , Su Ying , Weremowicz Stanislawa , Mulvey Laura , Yamamoto Shoji , Brennan Cameron , Mei Shenglin , Long Henry , Yao Jun , Polyak Kornelia
Published: March 2023

Supplementary Table S5. Pathway map enrichment of genes upregulated after expression of shCLK2 in MCF7 cells.
Supplementary Materials and Methods from Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53
Authors: Ng Jessica M.Y. , Martinez Daniel , Marsh Eric D. , Zhang Zhe , Rappaport Eric , Santi Mariarita , Curran Tom
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary Table S2 from CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer
Authors: Yoshida Taku , Kim Jee Hyun , Carver Kristopher , Su Ying , Weremowicz Stanislawa , Mulvey Laura , Yamamoto Shoji , Brennan Cameron , Mei Shenglin , Long Henry , Yao Jun , Polyak Kornelia
Published: March 2023

Supplementary Table S2. Copy number gain and expression of selected kinases in primary breast tumors based on qPCR.
Supplemental Figure S4 from Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53
Authors: Ng Jessica M.Y. , Martinez Daniel , Marsh Eric D. , Zhang Zhe , Rappaport Eric , Santi Mariarita , Curran Tom
Published: March 2023

Olig 2 is significantly reduced in Snf5F/F p53L/L GFAP-Cre adult mutant mice.
Table S6 from Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma
Authors: Guo Guangwu , Chmielecki Juliann , Goparaju Chandra , Heguy Adriana , Dolgalev Igor , Carbone Michele , Seepo Sara , Meyerson Matthew , Pass Harvey I.
Published: March 2023

Table S6. List of significant focal copy number alterations in the 22 MPMs
Supplementary Figure S2 from SND1 Acts Downstream of TGFβ1 and Upstream of Smurf1 to Promote Breast Cancer Metastasis
Authors: Yu Lin , Liu Xin , Cui Kang , Di Yanbo , Xin Lingbiao , Sun Xiaoming , Zhang Wei , Yang Xi , Wei Minxin , Yao Zhi , Yang Jie
Published: March 2023

Supplementary Figure S2. The collection of all q-RT-PCR results by using β-actin as reference gene.
Figure S3 from Disseminated Tumor Cells Persist in the Bone Marrow of Breast Cancer Patients through Sustained Activation of the Unfolded Protein Response
Authors: Bartkowiak Kai , Kwiatkowski Marcel , Buck Friedrich , Gorges Tobias M. , Nilse Lars , Assmann Volker , Andreas Antje , Müller Volkmar , Wikman Harriet , Riethdorf Sabine , Schlüter Hartmut , Pantel Klaus
Published: March 2023

Quantitative Western Blot analysis; detection of NOS2 and G6PD
Supplementary Figure 1 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: March 2023

A) PTENLOF/BRAFMUT melanoma lines were treated with serial dilutions of the indicated drugs and their effect on phosphorylated and total Akt was evaluated by RPPA. B) PTENLOF calls in CCLE translate into absence of PTEN protein as evaluated by immunoblotting in a panel of BRAFMUT melanoma lines using antibodies targeting the amino- and carboxy-terminus of PTEN. PI3Kβi1/2=rac-KIN-193/TGX221, panPI3Ki=GDC0941, PI3Kαi=BYL719
Supplementary Materials and Methods and Supplementary Figures 1 through 7 from Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas
Authors: Tang Xiaohu , Wu Jianli , Ding Chien-Kuang , Lu Min , Keenan Melissa M. , Lin Chao-Chieh , Lin Chih-An , Wang Charles C. , George Daniel , Hsu David S. , Chi Jen-Tsan
Published: March 2023

Supplementary materials and methods. Figure S1: VHL renders renal cancer cell resistant to cystine deprivation-induced cell death. Figure S2: Cystine deprivation induces a programmed necrosis in VHL-deficient renal cancer cells. Figure S3: VHL represses TNFalpha expression to protect from Cystine-deprived necrosis. Figure S4: Metabolomic and transcriptional response to cystine deprivation. Figure S5: Activation of Src and p38 kinases is required for cystine-deprived necrosis. Figure S6: Mutual amplification between the Src-p38-Noxa and TNF-RIP1/3-MLKL pathways. Figure S7: Low doses of erastin share a similar mechanism as cystine deprivation to trigger programmed necrosis in ccRCC.
Supplemental Methods from EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer
Authors: Amato Katherine R. , Wang Shan , Tan Li , Hastings Andrew K. , Song Wenqiang , Lovly Christine M. , Meador Catherine B. , Ye Fei , Lu Pengcheng , Balko Justin M. , Colvin Daniel C. , Cates Justin M. , Pao William , Gray Nathanael S. , Chen Jin
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary Figure S6 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: March 2023

Evaluation of the knockdown efficiency of PAI-1 in HUVECs transfected with siRNA against PAI-1
Supplementary Figure S2 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: March 2023

Effects of SK-216 on intrapleural tumors and pleural effusions of SCID mice inoculated with MPM cells
Supplementary Figure Legends from An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer
Authors: Olow Aleksandra , Chen Zhongzhong , Niedner R. Hannes , Wolf Denise M. , Yau Christina , Pankov Aleksandr , Lee Evelyn Pei Rong , Brown-Swigart Lamorna , van ‘t Veer Laura J. , Coppé Jean-Philippe
Published: March 2023

Legends for Supplementary Figures S1-S17.
Supplementary Materials and Methods, Figures 1 - 11, Tables 1 - 4 from Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells
Authors: Sakamoto Akihisa , Hino Shinjiro , Nagaoka Katsuya , Anan Kotaro , Takase Ryuta , Matsumori Haruka , Ojima Hidenori , Kanai Yae , Arita Kazunori , Nakao Mitsuyoshi
Published: March 2023

Supplementary Figure 1. Metabolic alteration in LSD1-inhibited cancer cells. Supplementary Figure 2. Overall view of the metabolomic analysis in LSD1-KD HepG2 cells. Supplementary Figure 3. GSEA results of the microarray experiment in LSD1-KD HepG2 cells. Supplementary Figure 4. Effect of LSD1-KD on energy metabolism in Huh-7, human hepatocellular carcinoma cells. Supplementary Figure 5. Effect of LSD1-KD on the expression of the glucose transporter GLUT1. Supplementary Figure 6. Overexpression of LSD1 in HepG2 cells. Supplementary Figure 7. Effect of LSD1-KD on the expression of metabolic genes in breast cancer cells. Supplementary Figure 8. Distinct expression of LSD1 in hepatocellular carcinoma and normal hepatic cells. Supplementary Figure 9. LSD1 regulates glycolytic genes through the HIF-1a-mediated pathway. Supplementary Figure 10. LSD1 physically interact with HDACs but not with HIF-1a/HIF-1B in HepG2 cells. Supplementary Figure 11. Effect of LSD1 inhibition in mouse xenograft model. Supplementary Table 1. siRNAs target sequences. Supplementary Table 2. Concentrations of the metabolites indicated in Figure 1E. Supplementary Table 3. Full descriptions of the gene abbreviations used in this study. Supplementary Table 4. Primers used in the study.
Supplementary Figures S1-S5 from Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases
Authors: Tanei Tomonori , Leonard Fransisca , Liu Xuewu , Alexander Jenolyn F. , Saito Yuki , Ferrari Mauro , Godin Biana , Yokoi Kenji
Published: March 2023

Dynamic light scattering analysis of nAb-PTX dispersed in water. The mean diameter of the aggregates is 12.4nm ; Gross appearance of breast (4T1) and lung (3LL) liver metastasis following various therapies ; Histological evaluation (H&E) consequently revealed that the tumor diameters at microscopic level in breast (4T1 cells) or lung (3LL cells) liver metastases were significantly smaller in the mice treated with MSV-nAb-PTX as compared to other therapy groups ; Dose response curves of viability of 4T1, 3LL cells, and abdominal macrophages treated with nAb-PTX and MSV-nAb-PTX as determined by MTT and WST-1 assay ; MSV biodistribution in 4T1 primary tumor and liver in the mice pre-treated with/without clodronate liposomes was evaluated by ICP-AES analysis .
Supplementary Figures 1 through 9 from Activated Thyroid Hormone Promotes Differentiation and Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt and BMP4 Signaling
Authors: Catalano Veronica , Dentice Monica , Ambrosio Raffaele , Luongo Cristina , Carollo Rosachiara , Benfante Antonina , Todaro Matilde , Stassi Giorgio , Salvatore Domenico
Published: March 2023

Supplemental Material. Fig. S1: Summary of TRα and β, MCT8 and MCT10 expressions in the cell lines used in this study. Fig. S2: E-Cadherin and sucrose isomaltase expressions. Fig. S3: Flow cytometry profiles on freshly purified CRC cells. Fig. S4: Functional promoter studies in HEK293 cells treated or not with 30nM T3 in the presence of an empty vector or TRα expressing plasmid. Fig. S5: FACS analysis of cell cycle distribution of CR-CSCs untreated and treated with T3, FBS or FBS plus rT3. Fig. S6: p21 and p27 protein expression levels measured by western blot analysis in CR- CRC cells under different conditions. Fig. S7: Hes-1 expressions in cells knocked down for D3 (iD3). Fig. S8: Clustergrams of up and down-regulated Wnt Targets- and Pathways-related genes in CR-CSCs treated cells.Fig. S9: Representative H&E, CK20, Ki67, CD133 immunohistochemical analysis of cells treated with different THs.
Supplementary table 3 from Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism
Authors: Jia Min , Andreassen Trygve , Jensen Lasse , Bathen Tone Frost , Sinha Indranil , Gao Hui , Zhao Chunyan , Haldosen Lars-Arne , Cao Yihai , Girnita Leonard , Moestue Siver Andreas , Dahlman-Wright Karin
Published: March 2023

Changed levels of intracellular metabolites in MCF7 and T47 D cells in response to estrogen
Supplementary Materials and Methods and Supplementary Figure and Table Legends from Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism
Authors: Jia Min , Andreassen Trygve , Jensen Lasse , Bathen Tone Frost , Sinha Indranil , Gao Hui , Zhao Chunyan , Haldosen Lars-Arne , Cao Yihai , Girnita Leonard , Moestue Siver Andreas , Dahlman-Wright Karin
Published: March 2023

Supplementary Materials and Methods and Supplementary Figure and Table Legends
Supplementary Table S2 from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Authors: Bakdash Ghaith , Buschow Sonja I. , Gorris Mark A.J. , Halilovic Altuna , Hato Stanleyson V. , Sköld Annette E. , Schreibelt Gerty , Sittig Simone P. , Torensma Ruurd , Duiveman-de Boer Tjitske , Schröder Christoph , Smits Evelien L. , Figdor Carl G. , de Vries I. Jolanda M.
Published: March 2023

GSEA raw data generated by Bubble GUM software.
Supplementary Figures 1-8 from Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest
Authors: Schaaf Lea , Schwab Matthias , Ulmer Christoph , Heine Simon , Mürdter Thomas E. , Schmid Jens O. , Sauer Georg , Aulitzky Walter E. , van der Kuip Heiko
Published: March 2023

Supplemental Figures (Supplementary Fig. 1-8): Cell lines are HR proficient (Supplementary Fig. 1); Influence of hyperthermia on the quantity of intra-nuclear Pt-DNA adducts and intracellular doxorubicin concentration (Supplementary Fig. 2); Hyperthermia sensitizes tumor cells to drugs which induce PARylation without altering PARP of PARG protein levels (Supplementary Fig. 3); Hyperthermia leads to a delayed DNA strand break repair capacity in different cell lines from ovarian and colon cancer (Supplementary Fig. 4); HR competence in 14 of 15 samples from PC patients (Supplementary Fig. 5); Gamma-irradiation leads to induction of γH2AX foci in all cells independent of proliferation status (Supplementary Fig. 6); Hyperthermia has no acute effect on cisplatin or doxorubicin induced apoptosis (Supplementary Fig. 7); Combined treatment of cells with hyperthermia and PARPi slightly enhanced the potentiating effect of either treatment alone (Supplementary Fig. 8).
Supplementary Dataset S1 from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Authors: Bakdash Ghaith , Buschow Sonja I. , Gorris Mark A.J. , Halilovic Altuna , Hato Stanleyson V. , Sköld Annette E. , Schreibelt Gerty , Sittig Simone P. , Torensma Ruurd , Duiveman-de Boer Tjitske , Schröder Christoph , Smits Evelien L. , Figdor Carl G. , de Vries I. Jolanda M.
Published: March 2023

The detailed composition of all gene sets used in GSEA.