bluuebunny/crossref_metadata_2025 huggingface dataset:
MENINGKATKAN KEMAMPUAN BERFRAGMEN SISWA SMA NEGERI 2 DOLO MELALUI STRATEGI MODELING
Authors: Al-afandi Al-afandi
Published: March 2022

Permasalahan pada penelitian ini adalah bagaimana upaya meningkatkan kemampuan berfragmen siswa kelas XI SMA Negeri 2 Dolo melalui strategi modeling. Penelitian ini bertujuan untuk meningkatkan kemampuan berfragmen siswa melalui strategi modeling pada Mata Pelajaran Bahasa Inodonesia di kelas XI SMA Negeri 2 Dolo dengan jumlah siswa sebanyak 22 orang. Data dikumpulkan dengan menggunakan observasi dan angket. Hasil penelitian pada siklus I menunjukkan nilai rata-rata 5,04 dan tingkat kreatifitas kemampuan siswa memperoleht skor 6 sebanyak 5 orang, kemudian skor 5 diperoleh sebanyak 13 orang dan skor 4 sebanyak 4 orang. Pada siklus ke II nilai siswa mengalami peningkatan dengan porolehan persentasi kolektif rata-rata 7,63 dengan tingkat kreatifitas skor 8 diporoleh 14 siswa dan skor 7 diperoleh 8 orang siswa. Oleh karena itu, hasil penelitian menunjukkan bahwa menggunakan strategi modeling, untuk meningkatkan kemampuan berfragmen siswa XI SMA Negeri 2 Dolo dalam kategori berhasil.
ANALISIS KESALAHAN BERBAHASA DALAM INTERAKSI PEMBELAJARAN BAHASA INDONESIA SISWA KELAS VII MADRASAH TSANAWIYAH ALKHAIRAAT PINOTU
Authors: Idrus Idrus , Surtini Surtini
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan 1.Kesalahan lafal pada pembelajaran Bahasa Indonesia siswa Kelas VII MTs Alkhairaat Pinotu, 2. Kesalahan diksi ( pemilihan kata ) pada pembelajaran Bahasa Indonesia siswa Kelas VII MTs Alkhairaat Pinotu. 3. Kesalahan struktur kalimat pada pembelajaran Bahasa Indonesia siswa kelas VII MTs Alkhairaat Pinotu. Penelitian ini menggunakan rancangan deskriptif kualitatif, yaitu mengumpulkan menganalisis dan mengajukan data secara objektif mengenai objek penelitian yaitu analisis kesalahan berbahasa dalam kelas VII MTs Alkhairaat Pinotu. Hasil penelitian ini menunjukkan bahwa ditemukan 36 kalimat yang mengandung kesalahan,  yaitu, 1. Kesalahan lafal berjumlah 12 kesalahan disebabkan adanya Perubahan fonem,  dan Penghilangan fonem. 2. Kesalahan diksi berjumlah ( Pilihan Kata ) 8 kesalahan disebabkan Pemilihan kata kurang tepat Adanya BI Yang digunakan dilingkungan sekolah dan sekitarnya dan 3. Kesalahan struktur kalimat berjumlah 16 kesalahan yang disebabkan adanya keterbatasan kosakatadalam penyampaian kalimat yang baik dan benar
IMPLEMENTASI NILAI MORAL NOVEL KUBAH KARYA AHMAD TOHARI DALAM PEMBELAJARAN
Authors: Taha Nasim
Published: March 2022

This study aims to describe the form of moral values, story elements used to convey moral values ​​and techniques for conveying moral values ​​in the novel Dome by Ahmad Tohari published by Gramedia Pustaka Utama. This understanding is focused on problems related to the form of moral values, story elements used to convey moral values ​​and techniques for delivering moral values.Data collection techniques were carried out by reading and recording data points and analyzed by qualitative analysis techniques using content analysis methods. The validity of the data is done by semantic validity, while the reliability of the data is interrater reliability and interrater reliability.The results of the study are described as follows. The first point is the manifestation of moral values ​​in the novel Dome by Ahmad Tohari in the form of human relationships with God, namely belief in God, being grateful to God, and offering prayers. Human relationship with oneself, which is firm in stance, optimism, and completion.Human relations with other humans in the scope of the social environment, namely caring for others, being grateful, respecting others, seven, being patient, and helping each other. The two elements of the story that are used as a means to convey moral values ​​in the novel by Ahmad Tohari are characterizations
Hepatoprotective effect of morin via regulating the oxidative stress and carbohydrate metabolism in STZ induced diabetic rats
Authors: Shali Kochuvelickakathu Sivan , Soumya Neelakanta Pillai Padmakumari , Mondal Sukanta , Mini Saraswathy
Published: March 2022

Background: Diabetes mellitus is widely recognized as one of the leading causes of death and disability worldwide. Hyperglycaemia-mediated oxidative stress plays a significant role in the development and progression of diabetes - induced liver damage.Objective: The main aim of the study was to explore the modulatory effect of the flavonoid morin (3,5,7,2’,4’ -pentahydroxyflavone) on oxidative stress and carbohydrate metabolism in the liver of streptozotocin (STZ) induced diabetic rats.Methods: Diabetes was induced in male albino rats by intraperitoneal injection of streptozotocin (40 mg/kg body weight) and subsequently, the animals were given morin intragastrically at a dose of 50 mg/kg body weight for 60 consecutive days. At the end of the treatment period, the animals were sacrificed by an intraperitoneal injection of thiopentone sodium. Blood and liver tissue were collected for further biochemical evaluation and the effects were compared with diabetic rats administered metformin, a standard antidiabetic drug.Results: Elevated blood glucose and HbA1c levels in diabetic rats were significantly decreased by morin administration. Morin effectively modulated the alternations in the concentration of lipid peroxidation products, activities of antioxidant enzymes and carbohydrate metabolizing enzymes in the liver of diabetic rats. The overall effects were comparable with diabetic rats administered with metformin.Conclusion: The results of our study proved that the morin administration exerts hepatoprotective activity by decreasing oxidative stress and regulating the altered activities of carbohydrate metabolizing enzymes in diabetes.Keywords: diabetes, morin, liver, oxidative stress, carbohydrate metabolism
Risk factors for chronic kidney disease progression in patients with solitary kidney
Authors: KARAER BÜBERCİ Refika , DURANAY Murat
Published: March 2022

Introduction: The prevalence of chronic kidney disease (CKD) is rapidly increasing worldwide. Solitary kidney is also increasing in ranking among the CKD etiologies, because there has been a rapid increase in the number of radical nephrectomies due to an increased number of renal transplantations from live donors and an increased number of patients with renal cell carcinoma. The aim of the current study is to identify risk factors that affect the glomerular filtration rate (GFR) in individuals with solitary kidney.

Material and Method: The current study included 204 patients (75 with congenital, 129 with acquired solitary kidney). Laboratory data during the first and last admissions were recorded. Patients divided into two groups according to annual decline of eGFR. Group I and II consisted of patients whose annual decline eGFR was more than 1ml/min/1.73 m2 and less than 1ml/min/1.73 m2, respectively. In addition, patients were divided into two groups as patients with congenital and acquired solitary kidney. The first control is the first examination in the nephrology outpatient clinic for congenital solitary kidney patient and the post-operative examination on the fourteenth day after discharge from the hospital for the acquired solitary kidney patient. The final control is the examination within the last three months before reaching the primary endpoint of the study.

Results: Of the patients, 36.8% were male, and the average age was 57.16±15.04 years. The duration of the follow-up period was 6.48±3.69 years. Group I had higher rates of diabetes mellitus, cardiovascular disease, older age, higher mean blood pressure(MBP), glucose, CRP, total cholesterol (TC), LDL-cholesterol, non-HDL-cholesterol, triglyceride/non-HDL-cholesterol ratio and lower albumin. In the group with acquired solitary kidney, the patients were older, the incidence of cardiovascular diseases was higher, and the eGFR at the first and last admission was lower. There was no difference between acquired SK and congenital SK in terms of annual change in eGFR. In regression analysis CRP, LDL-cholesterol, non-HDL-cholesterol, TG/non-HDL-cholesterol ratio are independent risk factors on annual decline of eGFR. Having a congenital or acquired single kidney had no effect on the annual decline of eGFR. In addition, TC, TC/HDL-cholesterol, triglyceride/non-HDL-cholesterol, triglyceride/HDL-cholesterol ratios, non-HDL -cholesterol correlated with CRP positively.

Conclusıon:Patients with solitary kidney have higher risk of developing CKD. Inflammation and dyslipidemia must be paid attention to protect eGFR. Besides the atherosclerosis in the microcirculation, dyslipidemia affect eGFR through inflammation. Having a congenital or acquired single kidney has no effect on the annual decline of eGFR.
The efficiency of Coban bandage on acute phase edema among patients undergoing a flexor tendon repair
Authors: KAPAN Merve , VERGİLİ Özge , ALKAN Berat Meryem , KAPAN Nazife
Published: March 2022

Introduction: To evaluate the efficiency of 3M Coban self-adherent wrap application on early (1-4 weeks) edema among patients undergoing surgery following a flexor tendon injury in Zone V or distal.

Material and Method: The study included 56 patients who had flexor tendon injuries. The patients were randomized into two groups by the computerized randomization method. Both groups were applied the "Modified Duran Protocol" (MDP) early passive mobilization exercises and "Retrograde Edema Massage". In addition, was applied 3M Coban self-adherent wrap to Group II. Finger circumferences was measured using a tape measure, and the pain intensity was evaluated with a visual analog scale (VAS). A goniometer was used to measure the joint range of motion (ROM), the Duruoz hand index (DHI) to evaluate functionality level, and the quality of life was investigated using the short form-36 (SF-36).

Results: The results showed that was statistically significant differences in both groups compared to pre-treatment (p
Evaluation of thyroid dysfunctions frequency in the first trimester
Authors: UÇKAN Kazım , ÇELEĞEN İzzet , BAŞKIRAN Yusuf
Published: March 2022

Aim: The aim of the study is to determine the frequency of first-trimester thyroid dysfunction in pregnant women and to investigate the effect of thyroid dysfunction on some perinatal outcomes.

Material and Method: In the study, first-trimester Thyroid stimulating hormone (TSH), free T4 and free T3 hormone values of pregnant women who applied to our outpatient clinic were retrospectively scanned and recorded. As a result, 3224 pregnant women were included in the study. Pregnant women were evaluated as overt hypothyroidism, subclinical hypothyroidism, overt hyperthyroidism, subclinical hyperthyroidism and euthyroid according to TSH and fT4 values. Results of thyroid function tests of pregnant women and some perinatal results (age, gestational week, delivery type, baby gender, birth weight, gravida, parity, abortion) were compared

Results: In our study, the mean age of the pregnant women for screening was 28.6±3.1, the mean birth week was 38.7±2.1, and the mean birth weight was 3037±324.73.6% (n=2369) of the pregnant women were normal euthyroid, 0.71% (n=23) were subclinical hyperthyroidism, 0.65% (n=23) were overt hyperthyroidism, while 15.6% (n=507) were overtly hypothyroid and 9.4% 3 (n=304) were found to be subclinical hypothyroidism. A significant statistical difference was not found between thyroid outcome test results and perinatal outcomes (age, gravida, parity, abortion, birth strength, gestational age, delivery type, babies) (p> 0.05).

Conclusion: In our study, a high prevalence of thyroid disease, especially hypothyroidism, was observed in pregnant women. More studies should be done to evaluate the effect of thyroid functions on pregnancy outcomes.
Comparison of self-tapping and self-drilling screws in open reduction of mandible fracture
Authors: SANCAR Bahadır , ÜSTÜNDAĞ İrfan
Published: March 2022

Objective: The purpose of this study is to assess the early postoperative stability of screw systems with mini plates in the treatment of open reduction mandibular angulus fractures.

Material and Method: This study consisted of 3 groups of mini plate or screw fixation: a 1.6 mm diameter drill for Group 1, a 1.2 mm diameter drill for Group 2, and self-drilling screws without drilling in Group 3. We used 9 hemimandibles, 9 plates, and 36 screws in each group. We compared the self-tapping and self-drilling screw systems while maintaining the plate system constant. We generated angulus fractures in 27 hemimandibles taken from 14 sheep mandibles. We separated the samples into 3 groups, each with 9 hemimandibles. All the screws used in the study were 2 mm in diameter and 5 mm in length. We used the servo hydraulic test unit to apply force to the hemimandibles. We applied forces of 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, and 150 N to the hemimandibles and recorded the resulting displacements. Data were analyzed with IBM SPSS V23, and conformity to normal distribution was evaluated by the Shapiro-Wilk test.

Results: There was no difference between the groups in terms of the amount of displacement that occurred as a result of the applied forces.

Conclusion: In the treatment of mandibular fractures with open reduction, surgeons should focus on plate-related parameters rather than self-drilling and self-tapping of screws, or drill diameter.
The effect of altitude difference on gastrointestinal bleeding in the chronic period
Authors: POLAT Esra , İNANÇ İbrahim Halil , ŞABANOĞLU Cengiz
Published: March 2022

Aim: The susceptibility to gastrointestinal bleeding is observed with an increase in altitude. There is no recommendation regarding altitude in terms of drug selection and dose to be used in diseases requiring antiaggregant and anticoagulant use. In this study, we aimed to determine whether there is a difference between gastrointestinal bleeding requiring hospitalization due to the use of antiaggregant and/or anticoagulant therapy between two populations living at different altitudes.

Material and Method: This retrospective study was performed in two secondary care hospitals. Patients from Group B living in villages with an altitude of 9842 ft and above and Group F patients living in an area with an altitude of 30 ft were included. Patient’s demographic data, co-morbid diseases, antiaggregant and anticoagulant use, hemoglobin, hematocrit, MCV values and platelet count were noted.

Results: The study included a total of 118 patients with gastrointestinal bleeding. There was no statistically significant difference between the groups in terms of the drugs used by the patients, the types and numbers of drugs.

Conclusion: We found that there was no significant difference between the groups with different altitudes in terms of drugs used by patients with gastrointestinal bleeding, drug types and numbers.
Comparison of labral repair and biceps tenodesis concomitant with arthroscopic rotator cuff repair in patients between the age of 40 and 60
Authors: CENGİZ Bertan , OGUZKAYA Sinan
Published: March 2022

Aim: Superior labrum anterior to posterior (SLAP) lesions are frequently accompanied by rotator cuff tear (RCT). The optimal treatment for type 2 and 4 SLAP lesions with RCT were not established. We aimed to compare the clinical results of SLAP repair and biceps tenodesis (BT) concomitant with arthroscopic rotator cuff repair (ARCR) in patients between 40 and 60 years old.

Material and Method: Forthy three patients (16 male, 27 females) who received ARCR concomitant with SLAP repair or BT for full-thickness rotator cuff tear were evaluated retrospectively. The patients were divided into the two groups based on treatment methods (SLAP repair, Group 1, 20 patients), (BT, Group 2, 23 patients). American Shoulder and Elbow Surgeons (ASES) score, University of California Los Angeles (UCLA) shoulder score, visual analogue scale scores (VASs), and range of motion (ROM) values were used as outcome tools.

Results: The mean age of the patients was 48.8±5.03 years. There was no difference in preoperative shoulder and pain scores (P
Effects of blood group types on risk of infection, disease severity, and mortality in COVID-19 patients
Authors: GEMCİOĞLU Emin , BAŞER Salih , İNAN Osman , ASFUROGLU KALKAN Emra , GULER Bagdagul , KARAAHMETOĞLU Selma , HASANOĞLU İmran , GÜNER Rahmet , COPUROGLU Esra , ATEŞ İhsan
Published: March 2022

Aim: COVID-19 is an epidemic communicable disease that has been declared as a pandemic caused by severe acute respiratory syndrome coronavirus 2. Clinical studies have demonstrated that advanced age and comorbid conditions enhance the severity of the infection. The objective of this study was to examine the of effects of blood group types on risk of infection, disease severity, and mortality in COVID-19 patients.

Material and Method: Included in this study were 1618 patients who had been diagnosed with PCR confirmed COVID-19 infection. The age, gender, blood type, disease severity, need for intensive care, and deaths of the patients were analyzed retrospectively. For the distribution of the blood types in a healthy population, statistics for the blood types of individuals in Ankara for 2020 were obtained from the Republic of Turkey Red Crescent Blood Services and used as a healthy control group for comparison with the data of the patients included in the study.

Results: Among the COVID-19 patients, blood type A was the most common type at a rate of 46.2%. This was followed by blood type O at a rate of 28.4%. The least common blood type was found to be type AB at a rate of 9%. When compared to the healthy population, blood type A was determined to be statistically significantly more common in COVID-19 infection (p=0.07,). In contrast, blood type O was determined to be less common when compared to the healthy population (p
The role of inflammatory markers derived from complete blood count results in the diagnosis of intrahepatic cholestasis of pregnancy
Authors: IRAK Kader , BAYRAM Mehmet , BECERİK Tüba Fikriye
Published: March 2022

Objective: This study aimed to investigate complete blood count (CBC) markers, particularly those indicating systemic inflammation, in healthy subjects and those with mild and severe intrahepatic cholestasis of pregnancy (ICP).

Material and Method: Seventy-nine subjects with ICP and 100 healthy age-matched women who were matched based on their scheduled singleton deliveries (on the same day) were included. ICP was defined as the increase in serum bile acid levels ≥10 μmol/L coupled with pruritus which could not be explained by other conditions. Patients with ICP were further categorized to mild and severe ICP according to bile acid levels, as follows: Mild ICP (
Smartphone-based videoconference visits are easy to implement, effective, and feasible in Crohn's disease patients: a prospective cohort study
Authors: YILMAZ Hasan , DUMAN Ali Erkan
Published: March 2022

Aim: Crohn's disease patients require life-long follow-up resulting in frequent hospital visits. The benefits of telehealth have been established in the remote management of Crohn’s disease but the role of mobile technology is missing. Our goal was to determine the feasibility and effectiveness of smartphone-based real-time video visits.

Material and Method: We followed 139 patients with either traditional (FTF) or online clinics (OLV) at a university hospital between May 2020- December 2020. We measured patients' satisfaction, disease activity, visit outcomes, socioeconomic parameters, and travel expenses to assess the effectiveness and acceptance of OLV.

Results: Satisfaction scores were significantly higher at OLV compared to FTF (89.58±9.93 vs 70.85±18.51, p
Relationship of the CRP/albumin ratio and the systemic immune-inflammation index with Forrest classification in patients with gastrointestinal bleeding
Authors: BOZAN Öner , ATİŞ Şeref Emre
Published: March 2022

Aim: The present study aimed to investigate CRP/albumin ratio and the systemic immune-inflammation index (SII) and Forrest classification in patients who presented to the emergency department with acute upper gastrointestinal (GI) bleeding.

Materials and Method: Patients over 18 years of age who presented to the emergency department of our hospital with melena, hematemesis, and hematochezia and were diagnosed with upper GI bleeding via esophagoduodenoscopy were included in the study. Esophagoduodenoscopy results, and accordingly, the Forrest classifications, together with complete blood count, including hemoglobin, platelet, and neutrophil values, as well as demographic characteristics were recorded. SII (calculated by multiplying the platelet count with neutrophil count and dividing the value obtained by the lymphocyte count [platelet (P)×neutrophil (N)/lymphocyte (L)]) and CRP/albumin ratio was calculated.

Results: No statistically significant difference was observed among the Forrest classification groups in terms of the median SII values as well as median CRP/albumin ratios. However, a statistically significant difference in median CRP/albumin ratios was observed among the dichotomized Forrest classification groups.

Conclusion: The SII is not a reliable parameter either predicts GI bleeding or the Forrest classification in patients with upper GI bleeding. The CRP/albumin ratio might be a poor predictor of bleeding; however, it can not predict the Forrest classification.
Temperament and character traits in young men diagnosed with idiopathic scoliosis
Authors: MADEN Özgür , UMUR Levent , AKTAŞ Selman , ORHAN Serdar , YILDIRIM Cengiz
Published: March 2022

Introduction: The aim of this study is to examine whether the temperament and character traits of young men diagnosed with idiopathic scoliosis (IS), known as the three-dimensional deformity of the spine and trunk, which begins to emerge during the growth period and progress with changes in the quality of life in adulthood, are different from those without idiopathic scoliosis.

Material and Method: A total of 162 IS and 162 healthy male individuals were included in the study. Scoliosis level was evaluated with the Cobb method and temperament and character traits were evaluated with the Temperament and Character Inventory. The data were evaluated with SPSS ver.22.0 program and p
COVID-19 pandemic: depression and sleep quality in hemodialysis patients
Authors: YAVUZ Demet , DOĞRU BALAKBABALAR Ayşe Pınar , DEMİRAG Mehmet Derya , SEZER Siren
Published: March 2022

Introduction: Depression and sleep disturbance are prevalent comorbidities in hemodialysis patients. This study aimed to investigate the relationship between depressive mood, sleep disturbance, and the fear of COVID-19 Scale in hemodialysis patients during the pandemic process.

Material and Method: 116 hemodialysis patients followed up in our clinic and volunteered were included in the study. The socio-demographic characteristics of the patients and the laboratory test results studied in their routine follow-ups were obtained from the file records. Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and the Fear of COVID-19 Scale (FCV-19S) were applied through face-to-face interviews.

Results: 116 patients (70 males, 46 females) with a hemodialysis duration of 40 months (13-295) and age of 60.2±13.3 years were included in the study. The patients were divided into two groups according to their PSQI score as good sleeper (PSQI ≤ 5, n=66) and poor sleeper (PSQI >5, n=50). When evaluated by gender 28 (56%) female patients were in the poor sleeper group (p=0.002). Dialysis time was longer, BDI score and FCV-19 scale were higher in the poor sleeper group than the good sleeper group. PSQI score was positively correlated with dialysis time (r=0.259 p=0.005), BDI score (r=0.279 p=0.002), and FCV-19 scale (r=0.304 p=0.001). In the Multiple Logistic Regression analysis established to evaluate the risk factors affecting sleep quality, BDI was determined as an independent risk factor for poor sleep (OR: 1.084, 95%CI [1.021-1.152], p=0.008). Subjects were divided into two groups according to their BDI scores as those with depressive mood (BDI score ≥ 17, n=47) (40.5%) and those without (BDI score < 17, n=69) (59.5%). Thirty-two of the cases with depressive mood were women (68.1%) (p
Platelet-lymphocyte ratio predicts poor prognosis in stage II/III colon and rectum cancer
Authors: BENEK Suat , PEDÜK Şevki , ZENGIN Mehmet
Published: March 2022

Objective: There is an increasing number of studies in the literature reporting that serum platelet/lymphocyte ratio (PLR) can provide useful prognostic data for various cancers. In the present study, the effects of platelet-lymphocyte ratio on survival in stage II/III colorectal cancers (CRC) were examined.
Material and Method:A total of 106 Stage II/III CRC patients who underwent curative surgery 2015-2020 were included in the study. Emergency cases and patients diagnosed with other than adenocarcinoma were excluded from the study. The demographic data of the patients, preoperative imaging and laboratory results, postoperative pathology reports, and patient follow-up examination data were obtained from hospital records. The relations between demographic, histopathological, hematological values ​​and the prognosis was analyzed in terms of statistical significance.
Results:Among the 106 patients, 62 (58.5%) were male and 44 (41.5%) were female. The mean age was 64.3±12.01 (23-89). The mean follow-up period was calculated as 24.6±15.8 (2-63) months. When the pathology reports were reviewed, it was found that the mean tumor diameter was 5.3±2.33 cm (2-17) and the mean metastatic lymph node was 1.8±2.4 (0-10). The PLR ratio was determined as a poor prognostic factor affecting survival in the cox regression analysis, in which preoperative complete blood count, c-reactive protein and albumin values, neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and PLR were compared, and was separated from other variables (P=0.002 CI= 95%). When variables such as age, clinical stage, and tumor diameter were included in the model, PLR was similarly found to be an important predictive variable (P= 0.002). When only NLR, LMR, and PLR were evaluated, PLR again came to the forefront with a significance value of P=0.01. Also, high neutrophil count, increased platelet distribution volume (PDW), advanced age, and perineural invasion (PNI) were found to be significant factors in predicting poor prognosis.
Conclusions: High PLR is a poor prognostic factor for CRC patients. For this reason, it may be necessary to follow a more aggressive strategy in the management of postoperative treatment in patients who have high PLR.
Comparison of the in vitro Demodex folliculorum killing activity of azelaic acid and permethrin
Authors: BOTSALİ Ayşenur , YÜREKLİ Aslan
Published: March 2022

Aim: Demodex parasites have been linked to dermatological disorders, especially rosacea, without a proven mechanism. Moreover, some anti-Demodex agents demonstrate a dual therapeutic effect related to a direct effect on the skin disorder along with a decreased number of Demodex mites. Despite being considered a first-line treatment approach for rosacea, azelaic acid's efficacy against Demodex mites has not been investigated. In the current study, mites were continuously observed after exposure to the test agents to evaluate the potential anti-Demodex efficacy of azelaic acid. The efficacy of azelaic acid was compared to that of a positive control agent (permethrin).

Material and Method: The wastes of diagnostic standardized skin surface biopsy samples of rosacea patients were collected for the trial. To four active treatment groups were administered 10% azelaic acid, 20% azelaic acid, 30% azelaic acid, and 5% permethrin. In addition, there was a control group, and 20 Demodex mites were included in each of the five groups. The authors conducted the real-time observation of the study groups through a digital microscope. The survival times of the mites were recorded and compared between the groups.

Results: The mean survival time was 12.2±1.5 minutes in the 5% permethrin group. The mean survival times in the 10%, 20%, and 30% azelaic acid groups were 15.8±1.6, 14±1.5, and 12±1.2 minutes, respectively. The differences between the four active treatment groups did not reach statistical significance (p>0.05).

Discussion: The present study’s results revealed that all three concentrations of azelaic acid had anti-Demodex efficacy comparable to that of 5% permethrin.
The effect of colchicine treatment on complete blood cell count-based parameters in patients with Behçet's disease
Authors: TEZCAN Dilek , TURAN Çağrı , YİLMAZ Sema
Published: March 2022

Aim: Behçet's disease (BD) is a systemic disease, with still unknown etiology and pathogenesis and varying disease presentations, characterized by recurrent oral aphthae, followed by genital ulcers, arthritis, variable skin and ocular lesions, gastrointestinal and central nervous system involvement, as well as, vascular disease. Colchicine is one of the oldest remedies still in use today. The study aimed to investigate the effect of colchicine on levels of the complete blood cell count-based parameters in BD.

Material and Method: A total of 117 (participants 60 healthy control and 57 patients with BD) were recruited from the rheumatology department in a single-center case-control study. The laboratory data were obtained from the electronic registration database. Laboratory findings of patients and healthy controls were evaluated. In addition, patients with BD were evaluated for these parameters before colchicine therapy and after 3-month from the beginning of colchicine treatment.

Results: The levels of inflammatory markers such as neutrophil count, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and systemic immune-inflammation index (SII), significantly higher than the control group before treatment, decreased to similar levels with the control group in the third month of colchicine use. However, red blood cell distribution width (RDW), mean platelet volume (MPV), and plateletcrit (PCT) were still statistically significantly different from the control group in BD patients.

Conclusion: SII, CRP, ESR, and NLR are useful parameters to evaluate the colchicine response of patients with mucocutaneous BD.
The effect of the COVID-19 pandemic on the increase of hyperlipidemia and metabolic syndrome in the Turkish population: a retrospective study
Authors: KARABULUT Alpaslan , ŞAHİN Mustafa
Published: March 2022

Aim: With the Coronavirus Disease 2019 (COVID-19) pandemic starting in late 2019 and continuing into 2020, permanent or periodic quarantine processes and curfews have been implemented. The objective of the study was to investigate the impact of extended quarantine processes during the pandemic on the development of metabolic syndrome (MET-S) due to physical inactivity.

Material and Method: This retrospective study consists of two groups. The first group consists of patients who applied to our hospital in the 12 months preceding the pandemic. The second group consists of the same patients who applied to the same hospital within 12 months of the onset of the pandemic. A total of 44,024 participants who had lab data prior to and during the pandemic were included in the study. Fasting plasma glucose (FPG), Triglyceride (TRIG), Total Cholesterol (T-Chol), High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol (LDL-C) levels and demographic characteristics of the patients were recorded. The test averages were compared between the two groups and their effects on the development of MET-S were subjected to statistical analysis.

Results: When we compared our patients' HDL-C, FPG and TRIG levels measured during the pandemic and the pre-pandemic period, we found a statistically significant increase (p100 mg/dL and TRIG>150 mg/dL during the pandemic was statistically significantly higher than during the pre-pandemic period (51.7% vs 45.8%, p
Severity of subchondral insufficiency knee fracture: is it associated with increasing age, femorotibial angle, and severity of meniscus extrusion?
Authors: BALTA Orhan , ŞAHİN Kübra , ZENGİN Çağatay , EREN Mehmet Burtaç , ALTINAYAK Harun , DEMİR Osman
Published: March 2022

Aim: To evaluate the relationship between severity of subchondral insufficiency fracture of the knee (SIFK) and age, gender, knee alingment, meniscus tear, type and location, severity of meniscus extrusion, and degree of knee osteoarthritis.

Material and Method: This retrospective study included 308 patients with SIFK seen on MRI. SIFK lesions were categorized as grade 1 to 4, with distinction between low grade (1 and 2) and high grade (3 and 4). The relationships between SIFK grade and patients' age, body mass index (BMI), femorotibial angle (FTA), meniscus tear,type and location meniscusextrusiongrade and osteoarthritis (grade 0 to grade 4) evaluated.

Results: According to the gender, 39.3% were men and 60.7% were women. The distrubutin of the SIFK grades were respectively 42.2% grade 1, 30.8% grade 2, 22.7% grade 3 and 4.2% grade 4. FTAwas positively correlated with SIFK grade (from grade 1 to grade 4, respectively; 4.42±2.57, 5.09±2.26, 5.74±2.78 and 5.95±2.54) (p=0.002). No statistically significant difference was observed between height, weight and BMI and the degree of SIFK.The mean FTA was 4.99±2.57° in SIFK. The FTA angles showed a stastistically significance between low (4.73±2.48°) and high (5.71±2.69°)grade SIFK (p:0.003). Roc analysis showed that the FTA above 3.1° and the age above 52 year old were at risk. The mean extent of meniscal extrusion was larger in high grade SIFK (p=0.001). Multivariable logistic regression analysis showed that compared with low grade SIFK, high grade SIFK was more closely associated with age, FTA, lateral meniscus extrusion and medial meniscus tear type.

Conclusion: High-grade SIFK lesions are associated with higher FTA and older age. In particular, patients with acute knee pain, older than 52 years of ageanda higher FTA than 3.1°, we recommend to perform knee MRI if possible.
Our convalescent plasma experiences in COVID-19 patients hospitalized in the intensive care unit
Authors: GÜVEN Bülent Barış , ERTÜRK Tuna , YILDIZ Egemen , DURMAYÜKSEL Esra , ERSOY Aysin , TANOĞLU Alpaslan
Published: March 2022

Objective: Despite vaccine and drug studies, convalescent plasma (CP) therapy remains an alternative treatment for coronavirus disease 2019 (COVID-19). In this study, we aimed to reveal the efficacy of CP therapy on mortality and the factors affecting it for the patients diagnosed with COVID-19 and acute respiratory distress syndrome (ARDS) which were followed in our intensive care unit (ICU).

Material and Method: The data (demographic characteristics, the amount of CP used, PaO2/FiO2, leukocyte, neutrophil, lymphocyte, D-Dimer, C-reactive protein (CRP), procalcitonin, ferritin values, and the clinical findings) of the patients who were hospitalized in the ICU with the diagnosis of COVID-19 and received CP treatment between 20 March and 20 October 2020 were analyzed retrospectively. Data of deceased patients (n=29) and survivors (n=50) were compared with each other and logistic regression analysis was performed to investigate the relationship with mortality.

Results: 79 patients who received 166 units of CP therapy after a mean of 13.45±3.6 days symptom onset, were identified. 96.2% of the patients had at least one concomitant disease. Mortality was observed in 29 (36.7%) of the patients. Mortality (5.1%) was less common in those receiving CP therapy within the first 14 days after the onset of symptoms. Patient age (p=0.041), neutrophil/lymphocyte ratio (p=0.004), CRP values (p=0.002), the number of comorbidities (p
Evaluation of the health literacy level of the patients who applied to a tertiary hospital family medicine clinic
Authors: PALA Emin
Published: March 2022

Aim: This study aimed to reveal the level of health literacy of the patients who applied to the family medicine clinic of a tertiary hospital in Turkey and its relationship with demographic parameters.

Material and Method: This study is a cross-sectional descriptive study. Study conducted in the family medicine clinic of an education hospital. Demographic characteristics and health literacy levels of the participants such as age, gender, marital status, educational status, professions, and financial status were noted. The health literacy levels of the participants were determined by using the Turkish Health Literacy Scale-32.

Results: A total of 443 participants were included in the study. the median age of the participants was 36. The median health literacy of the participants was 33.9 (25th and 75th quartiles: 29.2-40.8). The health literacy index of 57 (12.9%) participants were inadequate 139 (31.4%) participants was problematic, 147 (33.2%) participants were sufficient, and 100 (22.6%) participants was excellent. There was a statistically significant, negative, and weak correlation between age and health literacy index. (r=-0.200, p=0.01, Spearman correlation test).

Conclusion: Low health literacy is an important public health problem. Health literacy can be considered a priority policy issue. Legal arrangements can be made to carry out activities for health literacy.
Does prior uterine surgery increase the risks of uterine leiomyoma and adenomyosis? a retrospective study
Authors: MAVRAL Nihal , KIRICI Pınar , YAKUT Kadriye , AVŞAR Filiz
Published: March 2022

Aim: Women frequently undergo obstetric and gynecologic surgeries throughout their life, and the two common gynecologic conditions are uterine leiomyoma (UL) and adenomyosis. This study aims to investigate the relationship between the presence and the types of prior uterine surgery and the risks of developing UL and adenomyosis.

Material and Method: This study is a single-center eleven-year cross-sectional study, in which we studied the effects of previous uterine surgery on developing UL and adenomyosis in patients who underwent hysterectomy for any indication in our hospital between 01/01/2004 and 31/12/2014.

Results: During the time period, 1299 eligible patients were included in the study. The median age was 49.0 years and the study population was mostly consisted of multigravid women. The overall prevalence of UL was 61.9% and the overall prevalence of adenomyosis was 18.3%.In the univariate analysis of patient characteristics for UL, age, gravida and parity were found as statistically significant protective factors for UL (OR [95.0% CI]: 0.92 [0.91-0.93], 0.91 [0.88-0.95], 0.88 [0.83-0.93], respectively). On the other hand, women who underwent previous any uterine surgery had 1.28 folded (95.0% CI: 1.02-1.61) risk for UL. However, we found that only undergoing myomectomy statistically significantly increased the risk of UL (OR [95.0% CI]: 8.59 [2.62-27.91]) among the types of uterine surgery. In the multivariate model, the protective effect of age remained (adjusted OR [95.0% CI]: 0.92 [0.91-0.94]), and the risk-increasing effect of having previous myomectomy dropped slightly with retaining its statistical significance (adjusted OR [95.0% CI]: 5.87 [1.78-19.41]). We also conducted similar analysis for adenomyosis, and we found that gravida was a risk factor (OR [95.0% CI]: 1.06 [1.01-1.12]), conversely to its risk-decreasing effect for UL. Also, women who had a history of any uterine surgery had 1.42 folded (95.0% CI: 1.07-1.88), and women who had a history of D&C had 1.62 folded (95.0% CI: 1.02-1.61) risk adenomyosis. In the multivariate model for the risk of adenomyosis, the risk-increasing effects of the gravida and the history of D&C decreased very slightly with saving their statistical significances (adjusted OR [95.0% CI]: 1.06 [1.01-1.12], 1.44 [1.07-1.95], respectively).

Conclusion: According to our findings, the frequency of adenomyosis is higher but, the frequency of UL is compatible with the literature. Patients, who underwent uterine surgery previously, diagnosed with adenomyosis and UL more than the others who did not, but this seems to be a correlation rather than a causative association.
Mahiyeti Meçhul Bir Kütüphane: Galatasaray Kütüphanesinin Yapımı Hakkında Düşürülen Tek Türkçe Tarih Manzumesi
Authors: Çukurlu Talip
Published: March 2022

“Tarih Düşürme”, Osmanlı şairleri arasında rağbet görmüş bedi’ sanatlardan biridir. Şairler, Arap alfabesindeki her harfin mevcut rakamsal karşılığından faydalanarak şiire mevzu ettikleri olayların tarihini, şiirin dizeleri arasına gizlemişlerdir. “Ebced” adı verilen bu sistemle birden çok tarih düşürme yöntemi vardır. Kimi zaman bir mısradaki harflerin tamamı toplanır, kimi zaman sadece noktalı/noktasız harfler hesaba alınır, kimi zaman ise verilen ipuçları ile eklemeler veya çıkarmalar yapılarak istenen neticeye ulaşılır.
Osmanlı Devleti’nin yirmi dördüncü padişahı olan I. Mahmûd, imar faaliyetlerine önem vermiş, kütüphane yapımı veya kitap koleksiyonlarının zenginleşmesi için büyük çabalar sarf etmiştir. Osmanlı padişahları içinde en çok kütüphane yaptıran padişah unvanına sahiptir. Onun yaptırdığı kütüphanelerden biri olan Galatasaray I. Mahmûd Kütüphanesi veya diğer adıyla Galatasaray Mektebi Kütüphanesi bu makalenin konusunu oluşturmaktadır. Çalışmamızda, günümüzde mevcut olmayan kütüphanenin açılış tarihi için XVIII. yüzyıl Osmanlı şairi Vâsık-zâde Erşed tarafından düşürülen ve günümüzde tespit edilebilmiş tek Türkçe tarih manzumesi incelenecektir.
The Impact of COVID-19 Mandatory Lockdown on Various Aspects of Life Leading to Weight Regain in Patients Undergone Bariatric Surgery
Authors:   Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran, Molahosseini Reyhane , Mohammadi Farsani Taiebeh ,   Department of Medical Biotechnology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran, Mohammadi Farsani Gholamreza ,   Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Published: March 2022

Introduction: Mandatory lockdown of COVID-19 has caused a great impact in patients lives. Meanwhile, people underwent bariatric surgery are very susceptible to adverse effects of this social isolation. This study investigates the effects of COVID-19 lockdown on patients undergone previous bariatric surgery. Methods: Data source included PubMed and ScienceDirect. Articles were screened and eligible data was extracted. The outcomes of this study were the effects of lockdown on previous bariatric surgery that could lead to patient’s weight regain. Results: Our review study included 8 articles on 691 patients. COVID-19 lockdown had a profound effect on the lifestyle of people with a history of bariatric surgery. Many factors in the studies, including psychological factors such as depression, decreased social support, anxiety, eating habits such as reduced healthy food intake and lack of control over eating, and ultimately physical activity were negatively affected by the mandatory lockdown. Conclusion: The results of this review study demonstrated that social isolation during COVID-19 pandemic has caused many complications for patients underwent bariatric surgery, which can eventually lead to weight regain and recurrence of comorbidities in these population.
Evaluation effects of sleeve gastrectomy to bone metabolism and bone mineral densitometry in patients over 50 years
Authors:   Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Malekpour Alamdari Nasser , Zeinalpour Adel ,   Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hosseinipour Forough ,   Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kimia Fereshteh ,   Department of anesthesiology, labbafinezhad hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Gholizadeh Barmak ,   Department of General Surgery, shahid Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Published: March 2022

Background: Despite the improvement in health, function and quality of life of patients with morbid obesity following bariatric surgery, such intervention may result in some potential complications such as metabolic disturbances especially involving bone motabolism. The aim of this study was to evaluate the extent of Bone Mineral Density (BMD) changes in older patients with morbid obesity and its relation with bone metabolism indices. Methods: This study was a single-center cross-sectional study on 50 new morbidly obese patients over 50 years old of age who were candidates for bariatric surgery. Before and 6 months after surgery, the values of BMD, anthropometric indices and metabolic serum biomarkers were assessed. Results: BMD examination before and 6 months after surgery showed decrease in the BMD in hip region from 1.242 ± 0.136 to 1.117 ± 0.112 g/cm2, in the femoral neck from 1.109 ± 0.131 to 0.987 ± 0.127 g/cm2, in the lumbar spine from 1.253 ± 0.146 to 1.190 ± 0.135 g/cm2. The analysis of BMD changes showed significant decrease in the bone density of all site measurement but with variable amounts. The decrement of BMD in the hip and femoral neck was significant but in the spine was not significant. The analysis on bone metabolism markers showed significant increase in 25-Hydroxy vitamin D and Alkaline phosphatase levels but decrease in calcium and parathyroid hormone (PTH) during 6 month follow up. Conclusion: There is significant decrease in BMD at various skeletal areas including femoral neck and hip region. Such changes can be in line with the changes in some serum metabolic and hormonal biomarkers such as calcium, PTH, vitamin D and alkaline phosphatase.
Sleeve Gastrectomy Seems to Work Better in Male Patients With Morbid Obesity; A Prospective Cross-Sectional Study
Authors:   Associate Professor of Surgery, Clinical Research and Development Center at Shahid Modarres Hospital, Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Malekpour Alamdari Nasser , Moradi Mohammad ,   Resident of General Surgery, Firoozgar Research Development Center, Firoozgar Hospital, Tehran,, Safari Saeed ,   Assistant professor of surgery, Iran University of Medical Sciences, Firoozgar General Hospital, Tehran, Iran,, Tavoosi Anahita ,   Cardiology department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran, Besharat Sara ,   Assistant Professor of Radiology, Clinical Research and Development Center at Shahid Modarres Hospital, Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Asherloo Hamid ,   Resident of General Surgery, Firoozgar Research Development Center, Firoozgar Hospital, Tehran,, Larti Farnoosh ,   Cardiology department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Published: March 2022

Background: The predictors of successful outcomes after sleeve gastrectomy are not yet well recognized. Therefore, the purpose of this study was to assess factors predicting successful weight loss after surgery. Materials and Methods: This was a retrospective cohort study performed in Firoozgar hospital during 2017-2019. Overall, 128 patients with morbid obesity (103 females and 25 males; BMI range: 36.05 to 58.47 kg/m2) were included. The success of sleeve was defined either as Estimated Weight Loss (EWL) % >= 50% at 6 months or EWL% >= 65% at 12 months after surgery. We had two groups (successful and unsuccessful) at 6 and 12 months after surgery. Results; The mean ± SD of age, height, baseline weight and BMI (Body Mass Index) were 36.25 ± 11.11 year, 166.95 ± 9.65 cm, 119.40 ± 19.30 kg and 42.64 ± 4.03 kg/m2, respectively. Male and female patients were significantly different in reaching enough EWL% at 12 months after surgery (92.9% vs 56% respectively; p=0.012). The significant difference seen in mean ages between the two groups at 6 months (p=0.017) was disappeared at 12 months. In logistic regression analysis, the only independent factor to predict success was gender. Conclusion; The patient’s gender, height, weight or BMI, may have a predictive value to reach to a desirable weight after sleeve gastrectomy. Further investigations with large sample size are necessary to elucidate and predict more detailed findings.