bluuebunny/crossref_metadata_2025 huggingface dataset:
Recording the Costs of Restoring and Improving the Enterprise's Property, Plant and Equipment: Issues of Valuation, Accounting and Documentation
Authors:   Odesа Polytechnic National University, Selivanova Natalіа
Published: February 2025

This article examines the methodological aspects of reflecting the costs of restoration for the improvement of property, plant and equipment of an enterprise, as well as proposals for improving the accounting and documentation of such processes. The article analyses the interpretation of the concept of ‘property, plant and equipment’ provided in accounting regulations, considers the criteria for recognising property, plant and equipment as an enterprise asset. The methodology of accounting for the costs of restoring the efficiency and various types of improvement of property, plant and equipment is considered, the criteria for capitalising costs associated with the improvement of non-current tangible assets are presented. Recommendations for improving the analytical accounting of costs for the improvement of property, plant and equipment of an enterprise are proposed and documentary support for the calculation and generalisation of such costs is developed.
Type 2 diabetes remission through lifestyle intervention in a geriatric patient with long-standing diabetes and at thirty-three-months follow-up
Authors: Tripathi Pramod , Tiwari Diptika , Raizada Milanjeet Kaur , Kadam Nidhi
Published: February 2025

Type 2 diabetes (T2D) is a chronic metabolic disorder that affects millions of people worldwide, particularly the elderly population. Remission of T2D in elderly patients through lifestyle modifications has been well documented, especially in newly diagnosed patients with good glycemic control and without obesity. It is also common in patients with obesity undergoing bariatric surgery. In this report, we present the case of a 66-year-old male patient with a 30-year history of T2D and mild obesity who achieved remission of T2D through customized integrated intensive lifestyle modifications, including a vegan diet, exercise and psychological support. The patient showed an improvement in HbA1c (7.7 to 5.3%) and insulin resistance (HOMA-IR; 6.2 to 1.8) and a shift in BMI (25.3 to 23.7 kg/m2) through weight loss (73 to 67 kg). The patient remains in remission 33 months after the completion of the intervention. This case suggests the possibility of long-term remission with lifestyle changes in patients with advanced age, a longer duration of diabetes and mild obesity.

Learning points

Long-term sustained remission is possible in a geriatric patient with long-standing type 2 diabetes (T2D) of more than 30 years.

Customized integrated intensive lifestyle intervention can lead to a significant improvement in glycemic control and insulin resistance in elderly patients with T2D.

Integrated lifestyle interventions, including a vegan diet, exercise and psychological support, have the potential to stop the usage of oral hypoglycemic agents and insulin in an elderly patient with a prolonged history of T2D and mild obesity.
START:AV taikymas laisvės atėmimo bausmę atliekančių jaunų suaugusiųjų imtyje: psichometrinių charakteristikų ir konvergentinio validumo tikrinimas
Authors: Klimukienė Virginija , Laurinavičius Alfredas
Published: February 2025

In the penitentiary system, criminal risk assessment aids in tailoring the resocialization process and informs decisions about detention conditions and eligibility for conditional release. Risk assessment instruments such as START:AV facilitate both the identification of the risk level and the planning of targeted interventions. The final judgment about the risk is based on the analysis of risk and protective factors, which differ by age, leading to the implementation of separate assessment instruments for adolescents and adults. The transition from adolescence to adulthood does not occur with the 18th birthday; therefore, there is an increasing emphasis on extending correctional measures applied to adolescents up to the age of 24. The aim of the study is to examine the psychometric characteristics and convergent validity of START:AV, designed for adolescents, in a sample of male offenders aged 18 to 23. The study involved 99 young individuals incarcerated in four prisons in Lithuania. Negative correlations found between START:AV strengths and vulnerabilities align with the findings of other studies and support the assumption that although they are related, yet, they remain distinct constructs. The Achenbach System of Empirically Based Assessment (ASEBA) Adult Self-Report (ASR) was used to assess the convergent validity of START:AV. The results confirmed that START:AV may be applicable for assessing the risk of adverse outcomes in incarcerated adults aged 18–23. Further studies on its predictive validity in the sample of emerging adults would be necessary to substantiate the practical utility of this instrument.
Call to Action: Standardizing Follow-Up Care for Infants Prenatally Exposed to Opioids
Authors: Mills-Huffnagle Sara L. , Sullivan Rhea E. , Corr Tammy E. , Nyland Jennifer E.
Published: February 2025

Between 2007 and 2017, rates of neonatal opioid withdrawal syndrome (NOWS) have drastically increased. Although current evidence suggests that chronic prenatal opioid exposure may result in adverse neurodevelopmental consequences, there is no standardized protocol for the follow-up care of affected patients. We call on the American Academy of Pediatrics to develop a standardized protocol for the follow-up care of infants prenatally exposed to opioids that also supports families and providers. More specifically, special consideration should be given to identifying and providing solutions to barriers of care for families, as well as for providers. Educating families on the importance of follow-up care would also be beneficial, as well as educating providers on how to address family barriers. Prioritizing and attending to this call to action will allow for improvement in practice and patient care over time and potentially reduce hospital readmission rates commonly associated with NOWS.
Mecanismo molecular subjacente à propriedade de cicatrização de feridas in vitro do Stryphnodendron adstringens (Mart.)
Authors: Luiza Kaspary Pellenz Neida , Henrique Mastella Moisés , Farina Azzolin Verônica , Ferreira Teixeira Cibele , Köhler Carpilovsky Paula , Muller Brunelli Lucas , Köhler Carpilovsky Cristiane , Hilda Costabeber Ijoni , Beatrice Mânica da Cruz Ivana , Maria Medeiros Frescura Duarte Marta , Barbisan Fernanda
Published: February 2025

Objetivo: Analisar o mecanismo do extrato hidroalcóolico de barbatimão na indução da cicatrização células dérmicas de fibroblastos (HFF-1), em um modelo in vitro.
Métodos: Foram estudadas aqui duas concentrações de barbatimão utilizadas em pomadas comerciais (B1 = 0,49 mg/mL; B2 = 0,99 mg/mL), e seus efeitos foram avaliados com os seguintes marcadores às 24 e 72 horas após a indução da ferida in vitro: (1) metabolismo oxidativo [oxidação do DNA, lipoperoxidação, carbonilação de proteínas, enzimas antioxidantes (superóxido dismutase, SOD; catalase, CAT; glutationa peroxidase, GPX)]; (2) citocinas pró-inflamatórias (TNF-α, interleucina 6); (3) marcadores apoptóticos [caspase 3 (CASP3), CASP8, e fatores de crescimento:  de queratinócito (KGF) e de fibroblastos-1 (FGF-1)].
Resultados: O tratamento com ambas as concentrações mostrou diminuição nos marcadores pró-oxidantes, pró-inflamatórios e pró-apoptóticos, enquanto aumentava os níveis de antioxidantes e fatores de crescimento.
Conclusões:  O barbatimão atua por meio de um mecanismo pleiotrópico em cascata que envolve a modulação antioxidante, anti-inflamatória, anti-apoptótica e de migração/proliferação de fibroblastos. Nossos dados poderiam explicar o efeito e a importância do extrato de barbatimão nos mecanismos de cicatrização de feridas.
Caracterización del sistema de producción de nopal (Opuntia spp.) en la Huasteca de Tamaulipas, México
Authors: Zárate-Martínez William , Felipe Victoriano Moisés , Alcalá Rico Juan Samuel Guadalupe Jesús , Hernández Hernández Adán , Méndez Argüello Bulmaro , Arispe Vázquez José Luis
Published: February 2025

Introducción. En Tamaulipas, México se presentan las condiciones ambientales adecuadas para la producción del nopal; sin embargo, los rendimientos son inferiores a la media nacional. Objetivo. Caracterizar el sistema productivo de nopal en La Huasteca Tamaulipeca e identificar los principales problemas que limitan la producción. Materiales y métodos. Se realizó un diagnóstico del sistema productivo de nopal en La Huasteca Tamaulipeca, para lo cual, se aplicaron 28 encuestas de 65 preguntas, divididas en tres apartados: a) identificación del productor, b) caracterización de la unidad de producción familiar y c) caracterización técnico-productiva y comercialización. Resultados. La edad de los productores fue de 37 hasta los 78 años, con una media de 6,5 años de escolaridad. El 32 % del total de los productores no cuenta con asesoría técnica, el 57,1 % mencionó que sus tierras se encuentran bajo el régimen ejidal y el 100 % no utiliza maquinaria agrícola para sus actividades. El 82,1 % de los productores vende sus productos a intermediarios. Los productores de nopal de La Huasteca Tamaulipeca son en su mayoría adultos mayores con experiencia en el cultivo de nopal; sin embargo, la producción se realiza de forma tradicional, sin usar algún tipo de infraestructura, de temporal y con escaso acompañamiento técnico. Los principales problemas con los que se enfrentan los productores son los precios bajos originados por la poca demanda del producto; y la falta de asistencia técnica para el manejo del cultivo. Conclusiones. La producción de nopal en La Huasteca Tamaulipeca se realiza de forma tradicional, sin usar algún tipo de infraestructura, de temporal y con poco acompañamiento técnico. Los principales problemas con los que se enfrentan los productores son los bajos precios originados por la poca demanda del producto y la falta de asistencia técnica para el manejo del cultivo.
Archivos, descolonialidad y nuevos giros teóricos en América Latina
Authors: Agudelo Sebastián Alejandro Marín
Published: February 2025

El artículo revisa algunos trabajos referidos a los archivos subalternos, es decir de los grupos étnicos, indígenas y afrodescendientes, así como relativos al género, como las mujeres, comunidades LGBTQ+, campesinos, los archivos afectivos, espaciales, corporales, visuales y sonoros, entre otros, insertos en una lógica descolonial o que hacen énfasis en algunos de los nuevos discursos teóricos contemporáneos en las ciencias sociales, artes y humanidades en América Latina. Es una aproximación a un Estado de la cuestión, que sistematiza algunas de las posibilidades y ámbitos en los que se están dando estos nuevos abordajes de estudio, más allá de los relatos disciplinares de la archivística, que desde finales del siglo XX viene repensando sus postulados y objetivos, en cuanto al reconocimiento de nuevos productores de documentos y sujetos políticos y a las formas de registro de información y subjetividad de la memoria.
Análisis bibliométrico de las publicaciones del Instituto Geofísico del Perú: producción, colaboración, impacto y liderazgo científico
Authors: Lopez-Ramirez Joselyn , Limaymanta Cesar H.
Published: February 2025

La bibliometría, una disciplina clave dentro de las ciencias de la información, permite diagnosticar y evaluar los resultados de la investigación científica. En ese contexto, el presente estudio analiza la producción científica del Instituto Geofísico del Perú (IGP), indexada en Scopus durante el período 1961-2021. Se emplearon indicadores de producción, colaboración, impacto y liderazgo, además de evaluar el ajuste de la Ley de Lotka a los datos mediante el modelo del poder inverso generalizado. El análisis revela que el IGP ha publicado 624 documentos, esto evidencia un patrón creciente en su volumen de producción. Predomina el porcentaje de colaboración internacional (82.7 %), así como las publicaciones en revistas de cuartil 1 (71.9 %) y el porcentaje de documentos sin liderazgo institucional (67 %). Mediante el modelo del poder inverso generalizado se comprueba que la ley de Lotka no se ajusta a los datos de la literatura científica del IGP. Con la integración de diversos indicadores bibliométricos, este estudio se constituye en una herramienta estratégica para la gestión de la investigación, pues ofrece insumos valiosos para la toma de decisiones. Finalmente, se presentan recomendaciones para investigadores, gestores y tomadores de decisiones y, también, propuestas para futuras líneas de investigación orientadas al fortalecimiento institucional.
Multimorbidity and the combination of chronic non-communicable diseases and their relationship to all-cause mortality among Costa Rican older adults
Authors: Novak Beatriz
Published: February 2025

Objective: To estimate the prevalence of multimorbidity due to chronic non-communicable diseases, the prevalence of pairs and triads of these diseases and the respective associated mortality risks in older adults in Costa Rica. Methods: The data used belong to the study Costa Rica: Longevity and Healthy Aging Study. Gompertz models (adjusted for sociodemographic factors, health-related behaviors, and functional status) were estimated to assess the association of multimorbidity with all-cause mortality between 2005 and 2009. The study population comprised 2,565 individuals who provided data on all covariates at baseline. Results: The prevalence of multimorbidity was 42.6%. The five most frequent disease pairs combine hypertension with diabetes, coronary heart disease, respiratory conditions, arthritis, and osteoporosis (around 14%, 10%, 9%, 7%, and 6%, respectively). The most frequent disease triads were diabetes-hypertension-respiratory conditions and diabetes-hypertension-coronary heart disease (about 3% in both cases). Multimorbidity was associated with 64% increased mortality risk, not adjusting for functional limitations, and 37% when adjusting for functional limitations.  The following disease pairs at baseline increased the mortality risk, compared to persons without these combinations at baseline: diabetes-hypertension (49%); cancer-respiratory disease, diabetes-coronary heart disease, and diabetes-stroke (around two times); and cancer-hypertension and cancer-diabetes (around three times). The mortality risk among those with diabetes-hypertension-coronary heart disease and diabetes-hypertension-osteoporosis was twice that of persons without these diseases at baseline. Conclusion: There is a need to develop strategies to address the burdens that multimorbidity, particularly cardiometabolic multimorbidity, impose on individuals as well as on the healthcare system.
Life expectancy loss by education level and sex: the impact of COVID-19 in the US (2020) and their forecasts
Authors: Oviedo Carlos , Silva Urrutia Jose Eliud
Published: February 2025

Objective: Stratified life expectancy loss by education levels and sex helps measure particular mortality impacts during a catastrophic event. We propose a statistical approach to estimate them using the US case during the COVID-19 pandemic in 2020. Method: First, we estimate life expectancies according to available data, including those years when catastrophic events occur. Second, we use them to calculate a valid multivariate time series VAR(p) model, omitting the respective catastrophic(s) year(s). Through the model, we generate forecasts, which are compared with estimated data, and afterward, the life expectancy losses are quantified as their differences. Results: Less than four times the life expectancy losses with low education compared to the high education group. Our projections also indicate that life expectancies with almost all education falls outside the forecast intervals. Conclusion: The more educated the population is, the less life expectancy is lost. Women always outlive men within each education stratum. Long-term estimates continue to underscore gender disparities in life expectancy.
A robust stability criterion in the heat equation with a conformable fractional derivative defined on a radially symmetric sphere
Authors: Temoltzi-Ávila Raúl , Ávila-Pozos Roberto , Cruz-Castillo Ricardo , Jiménez-Munguía Ronald R. , Santillán-Hernández Alma S.
Published: February 2025

In this paper, we present a robust stability criterion for a heat equation with axial symmetry and with a general time-conformable fractional derivative defined on a sphere. The heat equation is assumed to have a heat source that is represented as a Fourier series with coefficients described by bounded, piecewise continuous functions. The robust stability criterion establishes conditions to guarantee that the solution of the heat equation, along with its partial derivative with respect to the radial axis and its general timeconformable fractional derivative, remains bounded by a predetermined value. The robust stability criterion is obtained by extending the concept of stability under constant-acting perturbations applied to systems of ordinary differential equations. The results are illustrated numerically.
Medición, simulación y evaluación de respuestas impulsionales para espacios acústicos con geometría rectangular
Authors: Abarca López Josué , Delgado Castro Alejandro
Published: February 2025

En este estudio se selecciona un espacio físico con geometría rectangular y se realiza un análisis comparativo entre los parámetros acústicos generados a partir de la medición in situ de sus respuestas impulsionales, utilizando un parlante unidireccional y los parámetros acústicos obtenidos a partir de métodos numéricos en un programa de simulación, donde se utiliza un parlante omnidireccional como fuente de sonido. Se evalúa también el posible beneficio de aproximar una fuente sonora onmidireccional mediante la rotación de una fuente unidireccional en el plano horizontal. Los resultados obtenidos indican que las mediciones realizadas con el parlante unidireccional permiten obtener una caracterización general de la acústica del espacio, con niveles de error que podrían ser tolerados, sobre todo a frecuencias medias, con la ventaja de tener un costo menor.
Agon interpretacji. Rola walki i rywalizacji w hermeneutyce Hansa-Georga Gadamera wobec „Rywalizacji Homera” Friedricha Nietzschego
Authors: Sznajder Paweł
Published: February 2025

Artykuł podejmuje problem roli walki i rywalizacji (agonu) w filozofii hermeneutycznej Hansa-Georga Gadamera, który jako jedno z istotnych źródeł swojej koncepcji wskazał grecki ideał wychowania. Filozof, poddając analizie wybrane aspekty filozofii Platona oraz relację retoryki i sofistyki, wyraźnie uznaje walor walki, pod warunkiem, że jest ona samodoskonalącą walką z samym sobą lub walką o prawdę i dobro. Funduje tym samym alternatywny względem Nietzscheańskiego, dialogiczny model hermeneutyki. Nietzsche dostrzega bowiem główny czynnik kulturotwórczy świata antycznego w rywalizacji. Ostatecznie Gadamer w swojej analizie Heglowskich kategorii panowania i niewoli odrzuca walkę jako przyczynę możliwego zakłamania interpretacji.
Methodological foundations of pharmaceutical development of cell-based preparations
Authors: Lyundup Alexey V. , Beregovykh Valery V.
Published: February 2025

Background. The Russian Federation and the Eurasian Economic Union (EAEU) have developed regulatory and legal bases for the circulation of cellular drugs — treatment products based on human somatic cells. Cellular preparations in the Russian Federation are represented by biomedical cellular products with a separate regulatory regulation from medicines, and in the EAEU cellular preparations are classified as a separate class of biological medicines — high-tech medicines. In both regulatory and legal regulations, a pharmaceutical approach has been applied, involving the pharmaceutical development of a cellular drug, its preclinical and clinical studies and subsequent registration for the possibility of release into civil circulation. Cellular drug developers and potential investors are faced with a number of regulated technological and organizational work related to pharmaceutical development that must be performed to bring cellular drugs to market. The requirements, recommendations, concepts and approaches existing in the world are described only for “traditional” medicines and do not describe the necessary types of work in the development of cellular drugs. Aims — to develop methodological foundations for the pharmaceutical development of cellular drugs, as well as to develop a scale of readiness levels of cellular drug technology. Methods. Analysis of the regulatory and legal bases of the Russian Federation and the EAEU, as well as on the basis of the life cycle of cellular drugs, ICH recommendations for the development of pharmaceutical products, the concept of “quality planned during development” QbD. Results. A methodological model for the creation of cellular preparations is proposed, including the stages of theoretical development, laboratory development and industrial development. Based on the methodological model, a scale of readiness levels of cellular drug technology (UGT1–UGT9) was proposed. Conclusions. This article proposes a methodology for the pharmaceutical development of cellular preparations, taking into account a specialized scale of technological readiness levels.
To the 75th anniversary of Academician of the Russian Academy of Sciences Anatoly A. Kulakov
Authors: Reshetov Igor V. , Usoltseva Natalia I.
Published: February 2025

October 18, 2024 marked the 75th anniversary of the birth of the country’s leading scientist, talented leader and teacher in the field of implantology and maxillofacial surgery, Honored Scientist of the Russian Federation, laureate of the Government of the Russian Federation in the field of science and technology, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences Anatoly Alekseevich Kulakov.
To the 75th anniversary of Academician of the Russian Academy of Sciences Sergei F. Goncharov
Authors: Zverev Vitaly V. , Reshetov Igor V. , Usoltseva Natalia I.
Published: February 2025

On October 19, 2024, Sergei Fedorovich Goncharov, the largest healthcare specialist, an outstanding scientist in the field of disaster medicine, a Russian statesman, a laureate of the Government of the Russian Federation in the field of science and technology, an Honored Scientist of the Russian Federation, an Honored Doctor of the Russian Federation, Academician of the Russian Academy of Sciences, turned 75 years old.
Genetic and epigenetic predictors of tongue squamous cell carcinoma sensitivity to platinum drugs
Authors: Kit Oleg I. , Engibaryan Marina A. , Gvaramiya Astanda K. , Volkova Victoria L. , Chertova Natalia A. , Kutilin Denis S.
Published: February 2025

Background. Treatment of locally advanced malignant tumors of the tongue at the present stage of development of clinical oncology is a difficult task and is an important problem in oncology. The aim — to screen for genetic and epigenetic predictors of locally advanced tongue cancer sensitivity to platinum therapy. Methods. A comprehensive clinical and molecular genetic examination was carried out in 100 patients with locally advanced malignant tumors of the tongue, as well as 30 donors without oncological pathology. The study used a new method for the treatment of locally advanced squamous cell carcinoma of the tongue using 2-stage superselective embolization as a component of complex treatment. At the first stage, a screening bioinformatics analysis was carried out to form a panel of genetic loci associated with sensitivity to therapy with platinum drugs. The determination of the relative copy number and expression of these loci responsible for repair and for the proliferation regulation and apoptosis was performed by Real-Time qPCR. Results. Integration of RNA-seq datasets, copy number variation data, and relevant clinicopathological information from TCGA and GEO databases allowed us to identify 65 genetic loci associated with sensitivity to platinum therapy. These genes were validated in patient biological material. Laboratory screening showed differential expression of BRCA1, BLM, ERCC1, EXO1, RAD50, PIF1, LIG1, BCL2, ERBB2, MAGEH1, NGFRAP1, and CASP8 genes, correlating with changes in their tissue copy numbers, between groups of patients sensitive and resistant to platinum therapy. The profile of gene copy numbers of BRCA1, BLM, EXO1, RAD50, PIF1, LIG1, CASP8, MAGEH1 and NGFRAP1 was detected in the blood plasma of patients with squamous cell carcinoma of the tongue, which was differential for two groups of patients — sensitive and resistant to platinum therapy. Based on bootstrap models, the final gene panel was obtained: BLM/NGFRAP1, BRCA1/MAGEH1, EXO1/RAD50, BLM/CASP8, BRCA1/RAD50 and BRCA1/EXO1, providing diagnostic sensitivity at the level of 95% and specificity at the level of 90% (AUC 0.98) when dividing patients into a group sensitive and resistant to platinum therapy. Conclusion. Comprehensive bioinformatics analysis of RNA sequencing data, gene copy number data, and clinical and pathological information from the TCGA and GEO databases, as well as laboratory screening of potential predictors, allowed us to obtain a panel of genes — BLM/NGFRAP1, BRCA1/MAGEH1, EXO1/RAD50, BLM/CASP8, BRCA1/RAD50, and BRCA1/EXO1, the combination of which provides high diagnostic sensitivity and specificity in dividing patients into a group susceptible and resistant to platinum therapy.
Modern Approaches to Identification of Pollutants Causing Toxicity of Water and Bottom Sediments of the Aquatic Ecosystems (a Review)
Authors: Yuryshynets V. I. , Konovets I. M. , Kipnis L. S. , Goncharova M. T. , Starosyla Ye. V. , Leontieva T. O. , Romanenko O. V.
Published: February 2025

The modern approaches to identification of pollutants that cause toxicity of water and bottom sediments were analyzed, which are mainly guided by the EDA (Effect Directed Analysis) methodology, based on biotesting of environmental mixtures in combination with successive reduction of the mixture complexity by physical-chemical manipulations/fractioning. The idea and procedure of TIE (Toxicity Identification Evaluation) consists in a sequence of analyses aimed at identification of substances causing toxicity in complex samples of the aquatic environment (matrices), in particular, bottom sediments. The performance of samples' examination according to this approach is divided into three phases: I - determination of the physical and chemical properties of the toxicity factor (Characterization); II - analytical determination of the toxicity factor (Identification), and III - prove that the determined toxicity factor is responsible for all detected negative effects (Confirmation). Various options for physical-chemical manipulation of water samples and bottom sediments in order to reduce their toxicity and narrow the range of assumptions regarding probable toxicity agent are considered.

Data on biotesting methodology, its modern modifications, and some standardized methods in Ukraine and the world are given.

The urgent need and possibility of the toxicological research development in Ukraine towards application of the state-of-the-art procedures of identification of the pollutants causing toxicity of water and bottom sediments in the aquatic ecosystems is shown.
State-of-the-art on impact and explosion behaviour of concrete structures: report of RILEM TC 288-IEC
Authors: Cadoni Ezio , Pérez Caldentey Alejandro , Colombo Matteo , Dancygier Avraham N. , di Prisco Marco , Grisaro Hezi , Martinelli Paolo , Ožbolt Josko , Pająk Małgorzata , Weerheijm Jaap
Published: February 2025

Extreme loads can arise from accidents such as vehicle collisions or airplane crashes, as well as deliberate acts of terrorism or military attacks involving blasts and fragmentation. Blast overpressure can also occur accidentally, for example, from explosions of hazardous materials such as gas. Distinguishing between accidental and deliberate loads is crucial for designing appropriate protection measures. The repercussions of extreme loading events can be devastating, leading to injuries, loss of life, economic setbacks, and significant social disruption. These consequences result not only from the direct effects of impacts or explosions, but also from secondary factors such as structural collapse, which is particularly concerning due to its potential for widespread devastation and substantial losses. Efforts to enhance the protection of concrete structures have focused on understanding the properties of construction materials and how structures respond to impact and blast loads. This document presents a comprehensive overview of RILEM TC 288-IEC, aiming to provide essential guidance for designing concrete structures to withstand extreme dynamic loads. This emphasizes the importance of a thorough understanding and accurate modelling of loading scenarios and material behaviour. By implementing the strategies outlined in this document, engineers can enhance the safety and resilience of structures facing such challenges.
Glomerular Filtration Rate Measurement Utilizing Transdermal Detection Methodology
Authors: Dorshow Richard B. , Debreczeny Martin P. , Goldstein Stuart L.
Published: February 2025

Background:

The well-known accuracy limitations of estimated GFR (eGFR) currently employed in clinical practice present barriers to optimal care for patients with, or at-risk for, decreased kidney function. A point-of-care glomerular filtration rate (GFR) measurement methodology has the potential to address these limitations. We prospectively assessed transdermal detection of the novel fluorescent GFR tracer agent relmapirazin in participants having normal or impaired kidney function across all human skin colors on the Fitzpatrick Skin Scale (FSS).

Methods:

A multi-center study comprising 74 participants with eGFR from normal to Stage 4 CKD was performed. Forty-six participants were FSS types I-III, and twenty-eight were FSS type IV-VI. A module containing an LED and photodetector to activate and collect transdermal relmapirazin fluorescence was attached adhesively to the upper chest of each participant. Relmapirazin (1.5mg/kg) was administered by intravenous push, and fluorescence emission was acquired for 12 hours. A two-compartment pharmacokinetic model fit the fluorescent intensity vs time data, and the fluorescence clearance rate (FCR) was extracted from the second (terminal) compartment. Plasma relmapirazin concentrations were measured contemporaneously and the corresponding plasma GFR for each participant was determined. Linear regression analysis was used to compare the FCR to the indexed plasma GFR.

Results:

Participant age range was 23 to 80 years old, with 59% females. The two-compartment pharmacokinetic behavior was observed in the fluorescence intensity vs time data and a FCR was successfully deduced for every participant completing the 12-hour study. The FCR vs. the indexed plasma GFR yielded an excellent correlation over the range of GFR measured and for all skin colors with a r2 = 0.90 (95% confidence interval 0.85 to 0.94). No severe adverse events were reported.

Conclusions:

Point-of-care transdermal detection of the fluorescent GFR tracer agent relmapirazin was feasible in patients with normal to impaired kidney function and for a range of skin color types.
Endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy after previous gastrectomy, Billroth II procedure or pancreatoduodenectomy
Authors: Sementsov K.V. , Savchenkov D.K. , Medvedeva A.V. , Koshelev T.E. , Gavrikova E.A.
Published: February 2025

Objective. To research the features of endoscopic treatment of choledocholithiasis and biliary strictures in patients with surgically altered anatomy of the upper gastrointestinal tract. Material and methods. A single-center retrospective study included 19 consecutive patients. Early outcomes including: the success of intubation of the afferent limb, the success of selective cannulation of the biliary ducts, the effectiveness of the performed operations; the frequency of complications; factors related to these indicators. Results. 3 (15.7%) patients failed intubation of the afferent limb. In 16 (84.2%) patients, endoscopic treatment was an effective final treatment method — regression of obstructive jaundice was achieved and cholangitis was stopped. 9 (69.2%) of 13 patients with choledocholithiasis, complete one-stage stone extraction was performed; 4 (30.8%) patients staged treatment was performed, during which 3 patients underwent cholangioscopy procedure with lithotripsy (laser and electrohydraulic). 3 patients with benign strictures underwent staged endoscopic treatment — multiple procedures to upsize and number of stents. In 1 (6.3%) 85-year-old patient with choledocholithiasis complicated by cholangitis and abscesses, surgery and complex therapy did not avoid a fatal outcome. There were no other complications. Conclusion. Endoscopic treatment of choledocholithiasis and biliary strictures in patients with surgically altered anatomy is a more difficult task. In a significant proportion of patients endoscopic treatment is effective. The success of the endoscopic treatment is due to the equipment of the hospital and the skills of physicians. It may be advisable to concentrate this technique in a centres with skill and expertise.
A vadlúd monitoring eredményei a 2012/2013-as idényben Magyarországon
Authors: Faragó Sándor
Published: February 2025

Jelen dolgozat folytatása mindazoknak a közléseknek, amelyek korábban, a libák állományváltozását mutatták be Magyarországon (STERBETZ, 1976; STERBETZ, 1983; FARAGÓ et al., 1991; FARAGÓ, 1995; FARAGÓ 1996, FARAGÓ & JÁNOSKA, 1996, FARAGÓ, 1998; FARAGÓ, 1999; FARAGÓ, 2001; FARAGÓ, 2002a; FARAGÓ, 2002b; FARAGÓ & GOSZTONYI, 2003; FARAGÓ, 2005; FARAGÓ, 2006; FARAGÓ, 2007a; FARAGÓ, 2007b; FARAGÓ, 2008; FARAGÓ, 2010a; FARAGÓ, 2010b; FARAGÓ, 2011a; FARAGÓ, 2011b; FARAGÓ, 2012).
История и культура Японии. Вып. 17
Authors: Трубникова Наталья , Коляда Мария , Мащеряков Александр
Published: February 2025

В 17-й выпуск "Истории и культуры Японии" вошли работы ведущих современных российских японоведов и молодых ученых по истории и культуре Японии от середины XIX в. до наших дней. Научному сообществу представляются новые материалы из российских и зарубежных архивов, переводы источников, исследования ряда памятников японской философской мысли, литературы, искусства. На нескольких примерах рассмотрены связи японской культуры с культурами нашей страны, стран Азии, Европы и США.
Для всех, кто интересуется историей и культурой Японии.
Hematoxylin and Eosin (H&E) Staining for Human Pancreas v1
Authors: Campbell-Thompson Martha , Fu Ann , Huang Hong
Published: February 2025

PURPOSE To provide instructions for using the automated Leica AutoStainer XL instrument to produce quality hematoxylin and eosin (H&E) stained slides from fixed paraffin-embedded samples for human pancreas studies by the HubMap Tissue Mapping Center- PNNL/UF (U54DK127823 (Qian, contact PI). SCOPE This procedure applies to tissue sections to be stained with H&E and includes instructions for properly using the Leica AutoStainer XL. This protocol is also used for paraffin-embedded sections following assay on the Nanostring GeoMx digital spatial profiler instrument and large paraffin-embedded sections placed on large format slides (2" x 3" slides). RESPONSIBILITIES The Lab Manager, or designate, is responsible for making sure that staff members are properly trained and equipment is appropriately cleaned, maintained in good working order, and available as requested. Lab staff members are responsible for reading and understanding this SOP and related documents and performing these tasks in accordance with the SOPs including cleaning and solution rotations and/orchanges.
Writing in the disciplines: Comparison of critical stance qualities in literary analyses by university students writing in L1 and L2 contexts
Authors: Ndoricimpa Clément , Barad Dilip P.
Published: February 2025

Construing critical stance in disciplinary writing is an important expectation. It is important because studies have shown a correlation between critical thinking and high score on writing. Therefore, this study compared the qualities of critical stance in literary analyses by university students in an outer circle country and by university students in an inner circle country. The data consisted of high-graded assignments by university students at seven universities in Gujarat state in India and successful assignments from British Academic Written English (BAWE) corpus. To analyze the data, appraisal theory- a subset of systemic functional linguistics- was employed. The results showed that university students in India predominantly construed in their literary analyses a descriptive and empty ethical stance. In contrast, university students in UK construed in their literary analyses a critic voice marked by caution, discourse alignment. Further, the results indicated that the descriptive and empty ethical stance was marked by the use of linguistic resources of affect and judgement in higher frequency while the critic voice in BAWE corpus was marked by the use of the linguistic resources of appreciation and engagement in higher frequency. These results have far-reaching implications for writing research and for assessing and teaching disciplinary writing in outer circle countries. They show evidence of the differences in the qualities of critical stance that students writing in L1 and L2 context construe in their disciplinary writing. They also give evidence of the differences in the assessment of students’ writing in L1 and L2 context.
Exploring the use of manga in translation practice: Insights from Vietnamese tertiary-level EFL lecturers
Authors: Thanh Thao Le , Trut Thuy Pham
Published: February 2025

This qualitative study explores the perceptions of Vietnamese tertiary-level English as a Foreign Language (EFL) lecturers regarding the use of manga in translation practice. With the growing interest in innovative language teaching methodologies, this research aims to provide insights into how manga, a popular Japanese graphic novel genre, can be integrated into language education to enhance learning experiences. The study involved semi-structured interviews with nine Vietnamese EFL teachers across different career stages, including three novice, three mid-career, and three near-end career teachers, from two educational institutions in Vietnam. A thematic analysis of the interview data revealed three key themes: enhanced engagement and motivation among students when using manga for translation exercises, challenges in maintaining academic rigor, and varied cultural perceptions and receptivity towards manga as a translation tool. Findings indicate that manga can significantly enhance student engagement and motivation, offering a culturally rich and visually appealing medium for language learning. However, challenges in aligning manga content with academic standards and maintaining language accuracy were noted. The study also highlighted diverse cultural attitudes toward the use of manga in educational settings, influenced by generational and pedagogical perspectives. This study contributes to the field of language education by providing empirical insights into the use of manga in translation practice, underscoring the importance of cultural sensitivity and pedagogical balance in incorporating innovative materials in language curriculums. It offers valuable guidance for educators and curriculum designers seeking to enhance language learning experiences through engaging and diverse educational resources.
French as a foreign language learners’ metacognitive strategy: A comparative study between Indonesia, Thailand, and Vietnam
Authors: Pranowo Dwiyanto Djoko , Tobing Roswita Lumban , Herman Herman , Van Cong Tran
Published: February 2025

Metacognition is central to language learning because it encompasses the processes that govern the efficient use of learning strategies. It is especially important as a way to address language learners’ issues of limited repertoire of strategies and their application. While much research on language learning strategies  have been related to the learning of English, this study observes the increasingly appealing French as an additional language hence French as a Foreign Language (FFL) is gaining importance. This research was carried out by examining some similarities and differences in models of learning strategies of FLE students in three ASEAN countries.  The present study aims to investigate into FFL learners’ metacognitive strategies which contribute to the development of learners’ autonomy, despite the different contexts of study in Indonesia, Thailand and Vietnam. This study is descriptive qualitative research involving 56 students from three universities in Bangkok (Thailand), Hanoi (Vietnam) and Yogyakarta (Indonesia) as an ad-hoc sample to study their French Language Education (FLE) learning strategies. Using a Metacognitive Strategy Questionnaire (MSQ), this study result in a few insights of FFL learning process. The participants showed a consistent metacognitive strategy in terms of planning, monitoring and evaluating. Even though they are located in different countries, these strategies are proved to contribute to their autonomy as an FFL learner with different specificities.
Mitigation strategies to manage rapport in the interaction between Iraqi veterinary students and their clients
Authors: Ahmed Wasan Khalid , Alkhawaja Hussein Walid , Nimehchisalem Vahid , Krishan Tamara
Published: February 2025

Soliciting accurate information about animals’ medical cases and maintaining harmonious relationships with clients require vets to use several mitigation strategies. This study analysed hedges, bushes, and shields proposed as mitigation strategies by Caffi (2007). In light of the Rapport Management Theory conceptualized by Spencer-Oatey (2008), the analysis was extended to include defining the roles of these strategies in expressing the relational work in terms of the interactional goals, sociality rights and obligations, and face sensitivities. For this purpose, the data were collected using a mixed-mode approach through audio-recordings and a client-satisfaction questionnaire, and then analysed using a discourse analysis (DA) following Dörnyei (2007). The findings showed that Iraqi veterinary students in this study employed bushes, hedges, and shields to mitigate their speech with bushes being the most frequently used. The use of these mitigators enabled the veterinary students to shield themselves against any future risks, solicit accurate information about the medical case of the animal, express politeness, maintain solidarity, and build good rapport with the clients. For clients, using these devices by the veterinary students enhanced clients’ face sensitivities, equity rights and identity, so they felt appreciated and valued. The findings about clients’ satisfaction revealed that Iraqi veterinary students need to increase their clients’ satisfaction by sharing the medical decision with clients and engaging clients regarding their animals during the medical visit. The findings would inform better veterinary students’ practices at the personal and interpersonal levels. The findings had also some pedagogical implications for veterinary stakeholders to improve veterinary students’ knowledge of the mitigation strategies through giving training courses that aim at improving the delivery of the communication skills within veterinary practice.
Inheritance of consonant phonemes from Proto-Austronesian into Acehnese: A comparative historical linguistics study
Authors: Dardanila Dardanila , Widayati Dwi , Gustianingsih Gustianingsih , Harahap Nur Hayati
Published: February 2025

Acehnese is a member of the Austronesian language family. As a descendant language, it retains significant vocabulary from Proto-Austronesian, while some vocabulary has evolved uniquely in Acehnese. In Comparative Historical Linguistics, such inheritance is termed linear inheritance, the direct preservation of phonemes from the ancestor language to the descendant language without significant change; and innovative inheritance, phonological modifications that occur as languages evolve over time. Despite the abundant of studies on Austronesian languages, there is only small portions discussing the preservation of specific consonant phonemes from Proto-Austronesian in its descendant languages. This study describes the inheritance of Proto-Austronesian consonant phonemes in Acehnese. It aims to contribute to the development of Comparative Historical Linguistics. In order to track the transmission of consonant phonemes from Proto-Austronesian to Acehnese, the study used the Comparative Historical approach. It is anticipated that this method will reveal patterns of phonological innovation and retention. By examining the evolution of consonant phonemes, this study reveals the mechanisms shaping the Acehnese language and offers insights into the historical phonology of Austronesian languages. It used a list of 200 Swadesh vocabulary items to demonstrate that many Proto-Austronesian consonant phonemes are inherited linearly in Acehnese (e.g., *b → b, *c → c, *d → d), while others show innovative changes (e.g., *p → t, *s → h). Our knowledge of the preservation of consonant phonemes during the history of Austronesian languages is anticipated to grow as a result of this work. Furthermore, it is anticipated that this research would shed light on certain linguistic mechanisms, such as phonological innovation and retention, that have shaped Acehnese's evolution as a descendant language. The study's findings also provide insights into more comprehensive language theories that differentiate between inventive and linear inheritance. These results give a framework for examining the phonological evolution of additional Austronesian languages, in addition to advancing the reconstruction of Proto-Austronesian phonology.
Trigeminal neuralgia associated with herpes zoster
Authors: Piradov Мikhail A. , Maksimova Marina Yu. , Sineva Nina A.
Published: February 2025

Neuropathy of the ophthalmic nerve (the first branch of the trigeminal nerve, CN V: V1) is the most common manifestation of herpes zoster. Neuropathy of the ophthalmic nerve occurs in 20% of cases of herpes zoster. Three types of pain are differentiated in trigeminal neuralgia: chronic burning pain, paroxysmal pain, and pain resulting from nonpain stimulation. Cutaneous hypoesthesia, anesthesia, and dysesthesia develop. Postherpetic neuralgia is characterized by pain persisting 3 months and longer after herpetic eruption. Combination therapy including early administration of antiviral drugs and tricyclic antidepressants has been proved to be most effective.