bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between empirically proportionate and disproportionate fears of cancer recurrence and anxiety and depression in uveal melanoma survivors: Five‐year prospective study
Authors: Brown Stephen L. , Hope‐Stone Laura , van der Voort Nicola , Hussain Rumana , Heimann Heinrich , Coventry William L. , Cherry Mary Gemma
Published: March 2024

Objective

Fear of cancer recurrence (FCR) may develop into elevated anxiety or depression symptoms, but few risk factors for this development are known. Objective recurrence risk estimation is possible in some cancers. Using theories of risk communication and phobias, we examined whether the proportionality of FCR to known objective recurrence risk influences the development of anxiety and depression symptoms.

Method

Uveal melanoma (UM) patients can opt for reliable prognostic testing. Patients experience either a ‘good’ or ‘poor’ prognostic outcome, whereby 10‐year mortality due to metastatic disease is, respectively, low or high. In a five‐year prospective study of a consecutive sample of 589 UM survivors, we used random intercept cross lagged panel analyses to examine whether proportionality differentially influences whether FCR progresses to anxiety and depression.

Results

Positive cross paths predicting anxiety from FCR were stronger in the poor prognosis group than the good prognosis and not tested groups. Prognostic group differences were not evident for depression.

Conclusions

FCR was more likely to progress to elevated anxiety symptoms when proportionate to the known objective recurrence risk. Objective evidence may play a prominent role in the development and structure of fear because it assumes a high epistemic weight that activates a wide range of emotional and cognitive responses. Interventions that assist survivors to tolerate FCR in the presence of higher recurrence risks may be important in reducing anxiety symptoms.
Children's participation in everyday life: An international overview
Authors: Kosher Hanita , Gross‐Manos Daphna
Published: March 2024

Much of the research on children's right to participation has focused on formal settings, with less attention given to everyday contexts. The current study explores the scope of children's participation in everyday life in the family, school and community. Based on a sample of 46 000 children from 32 countries, children's participation was found to vary across the different contexts. Moreover, the quality of the children's relationships with adults was found to be positively related to the degree of their participation. Finally, some cross‐national differences were found.
Prevalence and factors associated with polydrug use among clients seeking treatment for alcohol misuse
Authors: Lawson Samuel , Bryant Jamie , Freund Megan , Dizon Joshua , Haber Paul S. , Shakeshaft Anthony , Jefferies Meryem , Farrell Michael
Published: March 2024

Introduction

The aim of this paper was to examine the client and psychosocial characteristics associated with polydrug use in patients with alcohol misuse as their primary drug of concern (PDC) seeking treatment from substance use treatment centres.

Methods

Self‐report surveys were undertaken with clients attending 1 of 34 community‐based substance use treatment centres across Australia with alcohol as their PDC. Survey items included client's socio‐demographic characteristics, level of alcohol dependence, use of other drugs including tobacco, health and wellbeing factors including health‐related quality of life. The factors associated with polydrug use (alcohol use concurrent with at least one other drug) were examined.

Results

In a sample of 1130 clients seeking treatment primarily for alcohol problems, 71% reported also using another drug. The most frequently used drug was tobacco (50%) followed by cannabis (21%) and benzodiazepines (15%). Excluding tobacco use, 35% of participants reported polydrug use. Factors associated with any polydrug use were younger age, lower education levels, lower levels of mental health related quality of life and housing risk (i.e., risk of eviction or experienced homelessness in past 4 weeks). When tobacco was excluded, factors associated with polydrug use were age, lower physical and mental health‐related quality of life, and housing risk.

Discussion and Conclusions

Most adults seeking treatment for alcohol misuse as their PDC reported using another drug in addition to alcohol. Treatment services should be designed accordingly to maximise the likelihood of treatment engagement and success.
Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators
Authors: Domazet Sidsel L. , Olesen Thomas B. , Stidsen Jacob V. , Svensson Camilla K. , Nielsen Jens S. , Thomsen Reimar W. , Jessen Niels , Vestergaard Peter , Andersen Mette K. , Hansen Torben , Brøns Charlotte , Jensen Verena H. , Vaag Allan A. , Olsen Michael H. , Højlund Kurt
Published: March 2024

Aims

To determine the magnitude of the association between abdominal adiposity and low‐grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities.

Materials and Methods

We measured waist circumference, clinical characteristics, and inflammatory markers i.e. tumour necrosis factor‐alpha (TNF‐α), interleukin‐6 (IL‐6), and high‐sensitivity C‐reactive protein (hsCRP), in >9000 persons with recently diagnosed T2D. We applied multiple mediation analysis using structural equation modelling, with adjustment for age and sex.

Results

Waist circumference as a proxy for abdominal adiposity was positively associated with all inflammatory markers. Hence, a one‐standard deviation (SD) increase in waist circumference (SD = 15 cm) was associated with a 22%, 35%, and 46% SD increase in TNF‐α (SD = 1.5 pg/mL), IL‐6 (SD = 4.4 pg/mL), and hsCRP (SD = 6.9 mg/L), respectively. The level of hyperinsulinaemia assessed by fasting C‐peptide was quantitatively the most important mediator, accounting for 9%–25% of the association between abdominal adiposity and low‐grade inflammation, followed by low physical activity (5%–7%) and high triglyceride levels (2%–6%). Although mediation of adiposity‐induced inflammation by greater comorbidity and higher glycated haemoglobin levels reached statistical significance, their impact was minor (1%–2%).

Conclusions

In persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low‐grade inflammation. A considerable part (20%–40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity‐induced inflammation in T2D.
Blockchain technology in the supply chain management classroom: Proof of Attendance Protocols
Authors: Dreyfus David
Published: March 2024

This research demonstrates a method to introduce blockchain technology in the classroom based on the Proof of Attendance Protocol (POAP). A blockchain is a digital distributed ledger with the potential to improve transparency and trust between parties. Businesses are testing, piloting, and deploying blockchain technology across their organizations, and students show growing interest in the technology. This teaching brief proposes an exercise that uses POAPs, nonfungible tokens (NFTs) associated with an event, to help students understand blockchain technology within supply chain management contexts. Instructors can use the exercise for various purposes: as incentives for behavior the instructor wishes to encourage (such as attending class) or as prizes for games. The exercise also includes a glossary of blockchain‐related terms to introduce the language of this industry to students. Student surveys showed a significant change in their knowledge of blockchain technology, specifically, a 41% increase in understanding of how blockchain technology may benefit supply chain management and a 35% improvement in the ability to explain blockchain technology to others. This brief concludes with resources to create and distribute POAPs for courses and other settings.
Overwintering conditions affect cold hardiness, survival, and post‐overwintering fitness of the pea leaf weevil
Authors: Wijerathna Asha , Cárcamo Héctor , Evenden Maya
Published: March 2024

Overwintering conditions affect the physiological state of ectotherms, and therefore, their cold hardiness and survival. A measure of the lethal and sublethal impacts of overwintering conditions on pest populations is crucial to predict population dynamics and to manage pests the following spring. The impact of winter conditions can be most intense for invasive insects undergoing range expansion. Insect herbivores can display plastic host use behaviours that depend on their body condition following winter. The pea leaf weevil, Sitona lineatus L. (Coleoptera: Curculionidae), is an invasive pest of field peas, Pisum sativum L., and faba bean, Vicia faba L. (Fabaceae). Pea leaf weevil has expanded its range in North America to include the Prairie Provinces of Canada. This study investigated the effects of temperature and microhabitat on overwintering survival and cold hardiness of pea leaf weevil in its expanded range. Further, we investigated the sublethal effect of overwintering temperature and duration on post‐overwintering survival, feeding, and oviposition of pea leaf weevil. We also investigated the role of juvenile hormone in modulating body condition of overwintering weevils. The overwintering survival of pea leaf weevil adults increased with soil temperature and varied with region and microhabitat. More weevils survived winters when positioned near tree shelterbelts compared to open alfalfa fields. The supercooling point of pea leaf weevil varied throughout its expanding range but did not differ for weevils held in the two microhabitats. The average threshold lethal temperature of pea leaf weevil at all three sites was −9.4 °C. Weevils that overwintered for a longer duration and at a higher temperature subsequently fed more on faba bean foliage and laid more eggs compared to those which overwintered for a shorter duration at a lower temperature. Our findings highlight that warm winters would increase overwintering survival and post‐overwintering fitness, facilitating further pea leaf weevil invasion northward in the Prairie Provinces of Canada.
Does the Neotropical‐native parasitoid Ganaspis pelleranoi successfully attack the worldwide invasive pest Drosophila suzukii?
Authors: Biancheri María Josefina Buonocore , Núñez‐Campero Segundo Ricardo , Suárez Lorena , Ponssa Marcos Darío , Kirschbaum Daniel Santiago , Garcia Flávio Roberto Mello , Ovruski Sergio Marcelo
Published: March 2024

The Asian Drosophila suzukii (Matsumura) (Diptera: Drosophilidae) is a harmful invasive pest widespread throughout Argentinian fruit‐producing regions. It coexists with both pests, the sub‐Saharan African Ceratitis capitata (Wiedemann) and the Neotropical‐native Anastrepha fraterculus (Wiedemann) (both Diptera: Tephritidae), in northwestern Argentina. The Neotropical‐native parasitoid Ganaspis pelleranoi (Brèthes) (Hymenoptera: Figitidae) is frequently found in non‐crop fruit infested by those frugivorous dipterans. The northwestern Argentinian region is known for producing and exporting berries and citrus, which are affected by those pests. Thus, eco‐friendly control strategies are under assessment. This study mainly assessed the potential of the G. pelleranoi population lineage from Tucumán (GpTuc) as a D. suzukii biocontrol agent. First, both the host‐killing effectiveness and the reproductive success of GpTuc on larvae of D. suzukii, C. capitata, A. fraterculus, and Drosophila melanogaster Meigen were compared in no‐choice tests under laboratory conditions. Then, the GpTuc host preference was evaluated in dual‐choice tests (D. suzukii vs. C. capitata or A. fraterculus) under laboratory and field conditions. Naive parasitoid females were allowed to forage for 8 h on screen‐covered Petri dishes filled with host larvae under laboratory conditions and for 48 h on peaches inoculated with host larvae under field conditions. Host puparia dissections were performed to determine the number and condition of parasitoid eggs, first and second instars, such as alive/dead, without/with melanization process, and proportions of parasitized, superparasitized, and dead puparia. Drosophila suzukii was not a suitable host for the successful development of GpTuc immature stages as they did not overcome the host's immune system. However, GpTuc performed efficiently regarding D. suzukii mortality, but parasitoid specificity was restricted to both tephritid species as only thriving offspring were achieved from them. Interestingly, the effectiveness of GpTuc on D. suzukii increased when it co‐occurred with C. capitata instead of A. fraterculus, the preferred host.
Interactions between soil structure dynamics, hydrological processes, and organic matter cycling: A new soil‐crop model
Authors: Jarvis Nicholas , Coucheney Elsa , Lewan Elisabet , Klöffel Tobias , Meurer Katharina H. E. , Keller Thomas , Larsbo Mats
Published: March 2024

The structure of soil is critical for the ecosystem services it provides since it regulates many key soil processes, including water, air and solute movement, root growth and the activity of soil biota. Soil structure is dynamic, driven by external factors such as land management and climate and mediated by a wide range of biological agents and physical processes operating at strongly contrasting time‐scales, from seconds (e.g., tillage) to many decades (e.g., faunal activity and soil aggregation). In this respect, positive feedbacks in the soil–plant system may lead in the longer term to soil physical degradation or to the recovery of structurally poor soils. As far as we are aware, no existing soil‐crop model can account for such processes. In this paper, we describe a new soil‐crop model (USSF, Uppsala model of Soil Structure and Function) that accounts for the effects of soil structure dynamics on water and organic matter cycling at the soil profile scale. Soil structure dynamics are expressed as time‐varying physical (bulk density, porosity) and hydraulic properties (water retention, hydraulic conductivity) responding to the activity of biological agents (i.e., earthworms, plant roots) and physical processes (i.e., tillage, soil swell‐shrink) at seasonal to decadal time‐scales. In this first application of the model, we present the results of 30‐year scenario simulations that illustrate the potential role and importance of soil structure dynamics for the soil water balance, carbon storage in soil, root growth, and winter wheat yields on two soils (loam and clay) in the climate of central Sweden. A sensitivity analysis was also performed for these two scenarios using the Morris method of elementary effects, which revealed that the most sensitive parameters controlling soil structure dynamics in the USSF model are those determining aggregation induced by organic matter turnover and swell/shrink. We suggest that the USSF model is a promising new tool to investigate a wide range of processes and phenomena triggered by land use and climate change. Results from this study show that feedback in the soil‐crop system mediated by the dynamics of soil physical and hydraulic properties are potentially of central importance for long‐term predictions of soil water balance, crop production, and carbon sequestration under global change.
Exchangeable acidity and pedotransfer functions for the soils of Ghana
Authors: Owusu Stephen , Hartemink Alfred E. , Zhang Yakun , Csorba Ádám , Michéli Erika
Published: March 2024

Soil exchangeable acidity (EA) is an indicator of aluminium toxicity potential in acidic soils. Predicting the distribution and dynamics of EA is needed for the identification and management of acidic soils. In this study, we used datasets of 355 pedons from across Ghana and the Cubist rule‐based algorithm to generate pedotransfer functions (PTFs) of EA. Eight soil properties (pH, organic carbon, calcium, sodium, magnesium, total exchangeable bases, cation exchange capacity [CEC] to clay ratio and soil depth) were used to predict EA. We first used the whole dataset to construct generic PTFs and then stratified the dataset based on World Reference Base‐Reference Soil Groups (WRB‐RSGs) to generate soil‐specific PTFs. Goodness‐of‐fit statistics comprising the root mean squared error (RMSE), Lin's concordance correlation coefficient () and coefficient of determination (R2) were used to evaluate the prediction accuracy and reliability of the developed PTF models on both calibration and validation datasets. The Fluvisols EA‐PTF exhibited lower performance metrics in the validation (RMSE = 0.17 cmolc kg−1, = 0.19, R2 = 0.24), whereas the EA‐PTFs for all other WRB‐RSGs and whole dataset had above‐average performance metrics in the validation (0.05 ≤ RMSE ≤ 0.97 cmolc kg−1; 0.34 ≤ ≤ 0.94; 0.52 ≤ R2 ≤ 0.96). Soil pH sufficed for predicting EA in soils with pH above 5.0, but in soils with a pH < 5.0, the levels of exchangeable bases (e.g., Na+, K+, Mg2+, Ca2+), CEC to clay ratio (CCR) and soil depth improved the prediction of EA. The developed EA‐PTFs are useful for estimating the missing values of EA in soil databases.
Effect of severe wildfire on soil phosphorus fractions and adsorption in a cold temperate coniferous forest after 5 years
Authors: Deng Yating , Zhang Yun , Zheng Xinxin , Cui Xiaoyang
Published: March 2024

Forest fires are a primary driver of biogeochemical processes in ecosystems and affect the soil nutrient balance by altering the distribution of organic matter and associated nutrients as well as the composition and availability of elemental nutrients. We investigated the changes in soils’ phosphorus (P) fractions and the adsorption characteristics of potassium dihydrogen orthophosphate (orthoP) and myo‐inositol hexakisphosphate (IHP) at two depths (0–5 and 5–10 cm) in soils from two sites differing in fire severity: long‐unburned and heavily burned. Five years after the fire, there were increases in the total P and extractable inorganic P (H2O‐P, NaHCO3‐Pi, NaOH‐Pi, D.HCl‐Pi and C.HCl‐Pi) contents. Conversely, there was a decrease in organic P (NaHCO3‐Po, NaOH‐Po and C.HCl‐Po). The adsorption of soil for orthoP at a depth of 0–5 cm was dependent on the amount of P supplied by the soil; at low concentrations, heavily burned soil showed a lower adsorption than long‐unburned soil. However, at high concentrations, the adsorption of heavily burned soil was significantly larger than that of long‐unburned soil. With respect to IHP, the adsorption of long‐unburned soil was also more significant at depths of 0–5 cm. The adsorption of both orthoP and IHP of heavily burned soil was significantly higher than that of long‐unburned soil at a depth of 5–10 cm. Fire also decreased the binding degree (k1) of soil‐P and the solid phase at depths of 0–5 and 5–10 cm. The increase in P adsorption capacity outweighed the addition of P from ash, resulting in less leaching in heavily burned areas and minimizing P loss. Overall, forest fires significantly affect the adsorption characteristics and P fractions of soil, specifically orthoP and IHP, during the initial stage of postfire recovery. These effects are closely related to the direct influences of iron oxide, soil organic matter and aluminium oxide in the soil and may even produce relatively long‐term effects on the P recycling process of the entire ecosystem.
Straw addition promotes the nitrification process and the wheat yield linked to trophic interactions among microbes
Authors: Jia Chunhua , Zhou Guixiang , Qiu Xiuwen , Zhang Congzhi , Wang Jingkuan , Zhang Jiabao , Chen Lin , Ma Donghao , Zhao Zhanhui , Xue Zaiqi
Published: March 2024

Straw return with nitrogen (N) fertilizer can generally regulate soil N cycling by affecting the microbial community, thereby influencing crop productivity. Bacteria and fungi play a key role in nitrification, while the effects of soil microbial interactions that include protists under the condition of straw return and N fertilizer remain uncertain. Here, we evaluated the importance of the soil microbiome, particularly protists and ammonia‐oxidizing bacteria (AOB), in regulating the soil N transformation potential and wheat yields under different fertilization practices. The results showed that the activity of β‐1,4‐N‐acetylglucosaminidase (NAG) and the potential nitrification rate (PNR) increased significantly by 156.4% ~ 312.3% and 183.1% ~ 402.6% with the addition of N fertilizer and straw, respectively. The effect on PNR was greater for straw than fertilizer addition. The fertilization practices changed the microbial community structure, and there were stronger responses from the protists and AOB. The soil microbiome formed three closely co‐occurring modules (Modules 0, 1 and 2). Among them, Module 0 showed strong positive correlations with the soil total N, NAG, PNR and crop yield and may be the key ecological cluster. Moreover, the predatory protists Cercozoa, Conosa and Ochrophyta in Module 0 were significantly positively associated with the activity of NAG and the PNR, yields and AOB. The predatory protists in Module 0 may change the soil potential nitrification rate and enhance the yield of wheat by preying on the competitors of AOB. The results suggest that the incorporation of straw promotes the N transformation potential and wheat yields linked to trophic interactions between predatory protists and AOB in fluvo‐aquic soil.
Neurological autoimmunity in patients with non‐pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles
Authors: Mangioris Georgios , Halfdanarson Thorvardur R. , Lennon Vanda A. , Chang Bryce K. , Dubey Divyanshu , Dyck P. James B. , Flanagan Eoin P. , McKeon Andrew , Mills John R. , Pittock Sean J. , Zekeridou Anastasia
Published: March 2024

Background and purpose

Paraneoplastic neurological autoimmunity is well described with small‐cell lung cancer, but information is limited for other neuroendocrine neoplasms (NENs).

Methods

Adult patients with histopathologically confirmed non‐pulmonary NENs, neurological autoimmunity within 5 years of NEN diagnosis, and neural antibody testing performed at the Mayo Clinic Neuroimmunology Laboratory (January 2008 to March 2023) were retrospectively identified. Control sera were available from patients with NENs without neurological autoimmunity (116).

Results

Thirty‐four patients were identified (median age 68 years, range 31–87). The most common primary tumor sites were pancreas (nine), skin (Merkel cell, eight), small bowel/duodenum (seven), and unknown (seven). Five patients received immune checkpoint inhibitor (ICI) therapy before symptom onset; symptoms preceded cancer diagnosis in 62.1% of non‐ICI‐treated patients. The most frequent neurological phenotypes (non‐ICI‐treated) were movement disorders (12; cerebellar ataxia in 10), dysautonomia (six), peripheral neuropathy (eight), encephalitis (four), and neuromuscular junction disorders (four). Neural antibodies were detected in 55.9% of patients studied (most common specificities: P/Q‐type voltage‐gated calcium channel [seven], muscle‐type acetylcholine receptor [three], anti‐neuronal nuclear antibody type 1 [three], and neuronal intermediate filaments [two]), but in only 6.9% of controls. Amongst patients receiving cancer or immunosuppressive therapy, 51.6% had partial or complete recovery. Outcomes were unfavorable in 48.3% (non‐ICI‐treated) and neural autoantibody positivity was associated with poor neurological outcome.

Discussion

Neurological autoimmunity associated with non‐pulmonary NENs is often multifocal and can be treatment responsive, underscoring the importance of rapid recognition and early treatment.
Demographic patterns of walleye (Sander vitreus) reproductive success in a Wisconsin population
Authors: Davis Robert P. , Simmons Levi M. , Shaw Stephanie L. , Sass Greg G. , Sard Nicholas M. , Isermann Daniel A. , Larson Wesley A. , Homola Jared J.
Published: March 2024

Harvest in walleye Sander vitreus fisheries is size‐selective and could influence phenotypic traits of spawners; however, contributions of individual spawners to recruitment are unknown. We used parentage analyses using single nucleotide polymorphisms to test whether parental traits were related to the probability of offspring survival in Escanaba Lake, Wisconsin. From 2017 to 2020, 1339 adults and 1138 juveniles were genotyped and 66% of the offspring were assigned to at least one parent. Logistic regression indicated the probability of reproductive success (survival of age‐0 to first fall) was positively (but weakly) related to total length and growth rate in females, but not age. No traits analyzed were related to reproductive success for males. Our analysis identified the model with the predictors' growth rate and year for females and the models with year and age and year for males as the most likely models to explain variation in reproductive success. Our findings indicate that interannual variation (i.e., environmental conditions) likely plays a key role in determining the probability of reproductive success in this population and provide limited support that female age, length, and growth rate influence recruitment.
Structural insights into the recognition of the A/T‐rich motif in target gene promoters by the LMX1a homeobox domain
Authors: Lin Liqing , Deng Jie , Peng Junhui , Cui Jing , Wang Lei , Zhang Min , Gao Jia , Li Fudong , Shi Yunyu , Lv Mengqi
Published: March 2024

LIM homeodomain transcription factor 1‐alpha (LMX1a) is a neuronal lineage‐specific transcription activator that plays an essential role during the development of midbrain dopaminergic (mDA) neurons. LMX1a induces the expression of multiple key genes, which ultimately determine the morphology, physiology, and functional identity of mDA neurons. This function of LMX1a is dependent on its homeobox domain. Here, we determined the structures of the LMX1a homeobox domain in complex with the promoter sequences of the Wnt family member 1 (WNT1) or paired like homeodomain 3 (Pitx3) gene, respectively. The complex structures revealed that the LMX1a homeobox domain employed its α3 helix and an N‐terminal loop to achieve specific target recognition. The N‐terminal loop (loop1) interacted with the minor groove of the double‐stranded DNA (dsDNA), whereas the third α‐helix (α3) was tightly packed into the major groove of the dsDNA. Structure‐based mutations in the α3 helix of the homeobox domain significantly reduced the binding affinity of LMX1a to dsDNA. Moreover, we identified a nonsyndromic hearing loss (NSHL)‐related mutation, R199, which yielded a more flexible loop and disturbed the recognition in the minor groove of dsDNA, consistent with the molecular dynamics (MD) simulations. Furthermore, overexpression of Lmx1a promoted the differentiation of SH‐SY5Y cells and upregulated the transcription of WNT1 and PITX3 genes. Hence, our work provides a detailed elucidation of the specific recognition between the LMX1a homeobox domain and its specific dsDNA targets, which represents valuable information for future investigations of the functional pathways that are controlled by LMX1a during mDA neuron development.
A novel fracture criterion for elastic‐brittle cracked body under compression and shear conditions
Authors: Zhu Fengjin , Shi Sheng , Liu Fushen , Zhu Jiancai
Published: March 2024

When the elastic‐brittle cracked body is subjected to compressive‐shear loading, not only does the phenomenon of wing crack initiation and propagation occur, but there is also a notable incidence of secondary crack initiation and propagation due to shear stress. Moreover, the shear fracture toughness (KIIc) predicted by the fracture criterion in the framework of classical fracture mechanics is usually smaller than the tensile fracture toughness (KIc), which is inconsistent with the actual observations. Therefore, this research firstly establishes a mechanical model of an elastic‐brittle cracked body under biaxial compression considering three kinds of crack parameters and materials' mechanical properties. Then, the stress field characteristics at the crack tip are analyzed. Next, a compression‐shear mixed fracture criterion is proposed. Finally, the effects of the lateral pressure coefficient (λ), critical plastic zone size (rc), friction coefficient (f), and deformation parameters of the crack surface on the failure modes at the crack tip are investigated.
Homozygous HLA‐DQB1*06:02 combined with T‐cell receptor alpha polymorphism results in narcolepsy onset – A familial case report
Authors: Jervis Steven , Payton Antony , Verma Arpana , Thomasson Rachel , Poulton Kay
Published: March 2024

Narcolepsy is a life‐long neurological disorder with well‐established genetic risk factors. Human leukocyte antigen‐DQB1*06:02 remains the strongest genetic predeterminant; however, polymorphisms in genes encoding the T‐cell receptor alpha chain are also strongly linked. This case report shows the inheritance pathway of these genetic markers contributing to narcolepsy onset in a 17‐year‐old female.
Negative social capital and requests for resources in a developing country: The case of rural–urban migrants in Kampala, Uganda
Authors: Solano Giacomo
Published: March 2024

This article analyses the social networks of rural–urban migrant entrepreneurs in Uganda. While social contacts are often an important asset to access resources for migrants, they are often expected to financially support the members of their social networks. These claims for support are here labelled ‘negative social capital’, following Portes' seminal work. This paper focuses on the kinds of networks that are more likely to produce negative social capital, operationalized here as requests for financial resources, and links this to the discourse on bridging and bonding social capital. By means of a regression analysis, this article provides evidence of dense networks with a higher share of migrants (bonding social capital) being associated with negative social capital. In addition, both a higher share of contacts met before migration, which is related to bonding social capital, and a higher share of contacts living in the city, which is related to bridging social capital, are negatively associated with requests for resources. These findings suggest that migrants can instrumentally keep some contacts from before migration and acquire new key contacts in the urban area.
Exploring the impact of diet and nutrition on vitiligo: A systematic review of dietary factors and nutritional interventions
Authors: Hadi Zeenat , Kaur Ravneet , Parekh Zahra , Khanna Sukul , Khalil Ahmed Bazil Bin , Abbasi Haleema Qayyum , Ashfaque Faiza , Shah Dhruvi , Patel Vikaskumar Jitendrakumar , Hasibuzzaman Md Al
Published: March 2024

Background

Vitiligo, an autoimmune skin disorder linked to hormonal and genetic factors, results in reduced pigmentation due to a gradual decline in melanocyte activity. This systematic review delves into the role of dietary intervention and nutrition in managing vitiligo.

Methods

A comprehensive search on PubMed, Google Scholar, and European PMC identified 214 studies, with 14 meeting inclusion criteria post‐screening. The selected studies primarily explored the impact of dietary supplements on disease activity.

Results

Heavy metal exposure, specifically Cd, Pb, and Hg, indicated potential links to heightened reactive oxygen species and vitiligo development. Conflicting evidence emerged regarding the role of trace minerals (Zn and Cu), with some studies suggesting deficiencies and others proposing excesses in vitiligo patients. Vitamins with anti‐inflammatory properties like vitamin C, D, and B12, along with antioxidants, were investigated for their potential in repigmentation strategies. Additionally, polyunsaturated fatty acids (PUFAs), especially in varying types of fat consumption, were implicated. Emphasizing the need to reduce reliance on pharmacological and phototherapy interventions, the review uncovers novel roles for dietary supplements as adjuncts or flare reducers.

Conclusion

While dietary interventions cannot be thought of as a standalone therapy, they still make a case for being used as adjuncts. Large scale clinical trials are warranted to establish strong evidence and protocols, and might also help reduce the dependency on pharmacological methods, which come with their adverse effect profiles.
Daily general discrimination predicts changes in trait negative affectivity: A 30‐year cohort longitudinal study using a random‐intercept cross‐lagged panel model
Authors: Daurio Allison M. , Taylor Jeanette
Published: March 2024

Objective

Increasing evidence indicates discrimination is an emerging risk factor for reducing psychological well‐being. Negative affectivity is a personality trait that has been associated with discrimination. Yet, few studies to date have examined the longitudinal relationship between discrimination and personality. The current study addresses this gap by examining how general discrimination and negative affectivity influence each other longitudinally.

Method

The Midlife in the United States (MIDUS) dataset was used for the current study. The MIDUS sample (N = 4244) was predominately white (90.7%), 52% female, and had an average age of 46 years old. Individuals completed follow‐up measures 10 and 20 years after baseline. Data were analyzed using a random‐intercept cross‐lagged panel model.

Results

Individuals that scored higher on trait negative affectivity also tended to score higher on perceived daily discrimination. We found general perceived discrimination at age 55 unidirectionally predicted changes in negative affectivity around retirement age, but not from age 45 to 55. In contrast, negative affectivity did not significantly predict increases in perceived discrimination at any timepoint.

Conclusion

Our results indicate that perceived discrimination has pernicious impacts on well‐being up to a decade later and may do so by increasing an individual's tendency to experience negative emotions (i.e., negative affectivity).
Exploring work‐related stressors experienced by mental health nurses: A qualitative descriptive study
Authors: Cooper Alannah L. , Best Megan C. , Read Richard A. , Brown Janie A.
Published: March 2024

Introduction

The challenging work environments mental health nurses (MHNs) encounter can negatively impact their mental health, psychological well‐being and physical health. While these impacts have been investigated in quantitative research, little is known about work‐related stress from the perspective of MHNs.

Aim

To explore the stresses faced by nurses working in mental health settings and to gain an understanding of the underlying workplace context.

Method

A descriptive qualitative study with data collected via semi‐structured individual telephone interviews conducted with n = 21 Western Australian MHNs. Data were analysed using reflexive thematic analysis.

Results

A total of 85 codes were generated that led to the identification of 13 subthemes and 4 main themes: (1) mental health nursing context, (2) work environment stressors, (3) factors that alleviate stress and (4) the impact of workplace stress.

Discussion

Many of the stressors MHNs were exposed to are modifiable, such as understaffing and poor skill mix. Modifiable stressors increased risk for MHNs, impeded patient care and exacerbated inherent stressors such as patient acuity and complexity.

Implications for Practice

This study collected data that provide rich descriptions of the experiences of MHNs and identify modifiable work‐related stressors that could be alleviated through effective leadership and management.
Structure, floristic composition, and distribution of swamp forests across a white‐water flood‐plain in the Colombian Amazon
Authors: Urrego Ligia E. , Gutiérrez Mariana , Sánchez Mauricio , Elejalde Daniel , Correa‐Metrio Alex
Published: March 2024

Questions

The fluvial dynamics of meandering white‐water rivers of Amazonia drive vegetation primary succession. Directional successional processes have been recorded for the seasonal várzea forests that occupy well‐drained soils on levees and point bars across the spatial gradient of the flood‐plains. However, the types of forests occupying the swampy depressions interspersed between the point bars and their distribution along the flood‐plain's spatial gradient are poorly understood. Here, we aimed to unravel the spatial patterns of swamp forests along the sequence defined by an axis perpendicular to the river and the relationship with edaphic and spatial factors.

Location

The flood‐plains of the middle Caquetá River basin, Colombian Amazonia.

Methods

Forest types were identified by cluster analysis performed on 42 square plots (33 m × 33 m) set in poorly drained depressions of the flood‐plain. Floristic composition and vegetation structure as response data, and edaphic and spatial variables as predictors, were analyzed through partial redundancy analysis (pRDA). The effect of geographic position was included by using the first two axes of a principal coordinates of neighbor matrix analysis as conditional factors in the pRDA.

Results

The three identified swamp forest types were not arranged along a directional spatial pattern. Permanent várzea forests, closest to the river, showed the greatest diversity and alluvial sediment input. Oxandrales, furthest from the river, dominated by Oxandra polyantha, showed the greatest tree density, basal area and soil sand content, and received additional flooding from black‐water streams. Cananguchales, dominated by Mauritia flexuosa, exhibited the highest dominance and soil organic matter layer thickness. Distribution of the permanent várzea and oxandrales was relatively constrained by the distance to the river, whereas that of the cananguchales was not.

Conclusions

Flooding dynamics delay vegetation development of the swamp forests in permanent várzea and oxandrales. Cananguchales keep accumulating organic matter, becoming ombrotrophic peats after isolation from the river flooding influence. The swamp forests across these flood‐plains are far from being arranged along a linear sequence.
Wetting property of Fe‐S melt in solid core: Implication for the core crystallization process in planetesimals
Authors: Matsubara Shiori , Terasaki Hidenori , Yoshino Takashi , Urakawa Satoru , Yumitori Daisuke
Published: March 2024

In differentiated planetesimals, the liquid core starts to crystallize during secular cooling, followed by the separation of liquid–solid phases in the core. The wetting property between liquid and solid iron alloys determines whether the core melts are trapped in the solid core or they can separate from the solid core during core crystallization. In this study, we performed high‐pressure experiments under the conditions of the interior of small bodies (0.5–3.0 GPa) to study the wetting property (dihedral angle) between solid Fe and liquid Fe‐S as a function of pressure and duration. The measured dihedral angles are approximately constant after 2 h and decrease with increasing pressure. The dihedral angles range from 30° to 48°, which are below the percolation threshold of 60° at 0.5–3.0 GPa. The oxygen content in the melt decreases with increasing pressure and there are strong positive correlations between the S + O or O content and the dihedral angle. Therefore, the change in the dihedral angle is likely controlled by the O content of the Fe‐S melt, and the dihedral angle tends to decrease with decreasing O content in the Fe‐S melt. Consequently, the Fe‐S melt can form interconnected networks in the solid core. In the obtained range of the dihedral angle, a certain amount of the Fe‐S melt can stably coexist with solid Fe, which would correspond to the “trapped melt” in iron meteorites. Excess amounts of the melt would migrate from the solid core over a long period of core crystallization in planetesimals.
Mining oomycete proteomes for phosphatome leads to the identification of specific expanded phosphatases in oomycetes
Authors: Qiu Min , Sun Yaru , Tu Siqun , Li Huaibo , Yang Xin , Zhao Haiyang , Yin Maozhu , Li Yaning , Ye Wenwu , Wang Ming , Wang Yuanchao
Published: March 2024

Phosphatases are important regulators of protein phosphorylation and various cellular processes, and they serve as counterparts to kinases. In this study, our comprehensive analysis of oomycete complete proteomes unveiled the presence of approximately 3833 phosphatases, with most species estimated to have between 100 and 300 putative phosphatases. Further investigation of these phosphatases revealed a significant increase in protein serine/threonine phosphatases (PSP) within oomycetes. In particular, we extensively studied the metallo‐dependent protein phosphatase (PPM) within the PSP family in the model oomycete Phytophthora sojae. Our results showed notable differences in the expression patterns of PPMs throughout 10 life stages of P. sojae, indicating their vital roles in various stages of oomycete pathogens. Moreover, we identified 29 PPMs in P. sojae, and eight of them possessed accessory domains in addition to phosphate domains. We investigated the biological function of one PPM protein with an extra PH domain (PPM1); this protein exhibited high expression levels in both asexual developmental and infectious stages. Our analysis confirmed that PPM1 is indeed an active protein phosphatase, and its accessory domain does not affect its phosphatase activity. To delve further into its function, we generated knockout mutants of PPM1 and validated its essential roles in mycelial growth, sporangia and oospore production, as well as infectious stages. To the best of our knowledge, this study provides the first comprehensive inventory of phosphatases in oomycetes and identifies an important phosphatase within the expanded serine/threonine phosphatase group in oomycetes.
Determining land subsidence potential using the evidential belief function model: A case study for the Bardaskan Aquifer, Iran
Authors: Eghbali Mehdi , Azarakhshi Maryam , Khalaj Mohammad R.
Published: March 2024

In this study, we employed the evidential belief function model (EBF) to evaluate the potential for land subsidence in the primary aquifer of Bardaskan. Through field visits, we recorded GPS coordinates for 174 land subsidence points. Factors considered in assessing land subsidence potential included well density, groundwater extraction rate, geological characteristics, proximity to faults, vegetation cover, distance from the river, slope, and land use. To develop and validate the model, 70% of the recorded points were randomly selected for training and implementation, while the remaining 30% were reserved for model validation. The number and percentage of land subsidence points in the different classes of the corresponding layers were determined by integrating the training points with influential variables maps such as distance from the river, distance from the fault, land use, and extraction volume. The EBF model rate was calculated for different layer classes. For modeling, all rates of the EBF model in each cell were summated, and the ‎potential of land subsidence was calculated.‎ Finally, the map of land subsidence potential based on the EBF model was determined with GIS. The results showed that most of the subsidence points were located in alluvial sediment of the Holocene period, in areas with high groundwater harvesting, a distance of at least 3000 m from a river, a distance of at least 6000 m from a fault, low‐density rangelands, slopes of at least 0%–2%, and farmlands and gardens. A receiver operating characteristic curve analysis of the EBF model showed that it could accurately predict land subsidence in 87.5% of cases using 30% of the validation data. This suggests that the model can be used for practical applications.
Seedlings of Poncirus trifoliata exhibit tissue‐specific detoxification in response to NH4+ toxicity
Authors: Fan Z. , Lali M. N. , Xiong H. , Luo Y. , Wang Y. , Wang Y. , Lu M. , Wang J. , He X. , Shi X. , Zhang Y.
Published: March 2024

Ammonium nitrogen (NH4+‐N) is essential for fruit tree growth, but the impact of excess NH4+‐N from fertilizer on evergreen citrus trees is unclear.

In a climate chamber, 8‐month‐old citrus plants were exposed to five different hydroponic NH4+‐N concentrations (0, 5, 10, 15 and 20 mm) for 1 month to study effects of NH4+‐N on growth characteristics, N uptake, metabolism, antioxidant enzymes and osmotic regulatory substances.

Application of 10 mm NH4+‐N adversely affected root plasma membrane integrity, root physiological functions, and plant biomass. MDA, CAT, POD, APX and SOD content were significantly correlated with leaf N metabolic enzyme activity (GOGAT, GDH, GS and NR). GDH was the primary enzyme involved in NH4+‐N assimilation in leaves, while the primary pathway involved in roots was GS‐GOGAT.

Under comparatively high NH4+ addition, roots were the main organs involved in NH4+ utilization in citrus seedlings. Our results demonstrated that variations in NH4+ concentration and enzyme activity in various organs are associated with more effective N metabolism in roots than in leaves to prevent NH4+ toxicity in evergreen woody citrus plants. These results provide insight into the N forms used by citrus plants that are important for N fertilizer management.
A critical evaluation and research agenda for the study of psychological dispositions and political attitudes
Authors: Arceneaux Kevin , Bakker Bert N. , Fasching Neil , Lelkes Yphtach
Published: March 2024

Political psychologists often examine the influence of psychological dispositions on political attitudes. Central to this field is the ideological asymmetry hypothesis (IAH), which asserts significant psychological differences between conservatives and liberals. According to the IAH, conservatives tend to exhibit greater resistance to change, a stronger inclination to uphold existing social systems, and heightened sensitivity to threats and uncertainty compared with their liberal counterparts. Our review and reanalysis, however, question the empirical strength of the IAH. We expose major concerns regarding the construct validity of the psychological dispositions and political attitudes traditionally measured. Furthermore, our research reveals that the internal validity of these studies is often compromised by endogeneity and selection biases. External and statistical validity issues are also evident, with many findings relying on small effect sizes derived from nonrepresentative student populations. Collectively, these data offer scant support for the IAH, indicating that simply amassing similar data is unlikely to clarify the validity of the hypothesis. We suggest a more intricate causal model that addresses the intricate dynamics between psychological dispositions and political attitudes. This model considers the bidirectional nature of these relationships and the moderating roles of individual and situational variables. In conclusion, we call for developing more sophisticated theories and rigorous research methodologies to enhance our comprehension of the psychological underpinnings of political ideology.