bluuebunny/crossref_metadata_2025 huggingface dataset:
Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment
Authors: Cai Yuqi , Schrenk Sandra , Goines Jillian , Davis George E. , Boscolo Elisa
Published: August 2019

Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM). Gain-of-function mutations in the tyrosine kinase receptor TIE2 can cause VM and induce a ligand-independent hyperactivation of TIE2. Despite these important findings, the TIE2-dependent mechanisms triggering enlarged vascular lesions are not well understood. Herein we studied TIE2 p.L914F, the most frequent mutation identified in VM patients. We report that endothelial cells harboring a TIE2-L914F mutation display abnormal cell migration due to a loss of front-rear polarity as demonstrated by a non-polarized Golgi apparatus. Utilizing a three-dimensional fibrin-matrix based model we show that TIE2-L914F mutant cells form enlarged lumens mimicking vascular lesions present in VM patients, independently of exogenous growth factors. Moreover, these abnormal vascular channels demonstrate a dysregulated expression pattern of apico-basal polarity markers Podocalyxin and Collagen IV. Furthermore, in this system we recapitulated another pathological feature of VM, the paucity of pericytes around ectatic veins. The presented data emphasize the value of this in vitro model as a powerful tool for the discovery of cellular and molecular signals contributing to abnormal vascular development and subsequent identification of novel therapeutic approaches.
Nitro-functionalized metal–organic frameworks with catalase mimic properties for glutathione detection
Authors: Wang Jiayan , Li Wenying , Zheng Yue-Qing
Published: August 2019

Herein, four copper-based metal–organic frameworks were synthesized to investigate the effects of the substituents in ligands on the enzyme-like catalytic activity of these frameworks.
Biopolymer-enriched B. subtilis NCIB 3610 biofilms exhibit increased erosion resistance
Authors: Hayta Elif N. , Lieleg Oliver
Published: August 2019

By incorporating the macromolecule PGA into the matrix of B. subtilis biofilms, the superhydrophobobic properties of the material are enhanced.
Indirect state-of-charge determination of all-solid-state battery cells by X-ray diffraction
Authors: Bartsch Timo , Kim A-Young , Strauss Florian , de Biasi Lea , Teo Jun Hao , Janek Jürgen , Hartmann Pascal , Brezesinski Torsten
Published: August 2019

Ex situ and operando X-ray diffraction allows determining the state-of-charge of all-solid-state batteries in an indirect manner.
Atomistic simulations of bulk heterojunctions to evaluate the structural and packing properties of new predicted donors in OPVs
Authors: Marmolejo-Valencia Andrés F. , Mata-Pinzón Zaahel , Dominguez Laura , Amador-Bedolla Carlos
Published: August 2019

Electronic and packing properties exploration of BHJ with new predicted donors can lead to better optimized phases.
Purposefully designing novel hydroxylated and carbonylated melamine towards the synthesis of targeted porous oxygen-doped g-C3N4 nanosheets for highly enhanced photocatalytic hydrogen production
Authors: Song Peng , Liang Shuhua , Cui Jie , Ren Dong , Duan Ruyan , Yang Qing , Sun Shaodong
Published: August 2019

A new hydroxylated and carbonylated melamine was purposefully designed and constructed for the synthesis of targeted porous O-doped g-C3N4 nanosheets.
Titanium and zirconium complexes bearing new tridentate [OSO] bisphenolato-based ligands: synthesis, characterization and catalytic properties for alkene polymerization
Authors: Song Tingting , He Jianghao , Liang Liwei , Liu Ning , Li Feng , Tong Xiaobo , Mu Xiaoyue , Mu Ying
Published: August 2019

Titanium and zirconium complexes with new tridentate [OSO] ligands were synthesized and studied as catalysts for olefin polymerization reactions.
Assessment of cytotoxicity of metal oxide nanoparticles on the basis of fundamental physical–chemical parameters: a robust approach to grouping
Authors: Simeone Felice C. , Costa Anna L.
Published: August 2019

The most probable level of cytotoxicity of oxide nanoparticles can be determined on the basis of fundamental physical–chemical parameters that don’t need any experimental quantification.
Energetic materials with fluorinated four-membered heterocyclic ring: 3,3′-difluoroazetidine (DFAZ) salts
Authors: Chen Jifeng , Yu Yi , Zhang Shujuan , Li Yuchuan , Pang Siping
Published: August 2019

Fluorine atoms and four-membered rings form 3,3′-difluoroazetidinium (DFAZ) salts, which have a better detonation property than ammonium dinitramide (ADN).
A hierarchical porous architecture of silicon@TiO2@carbon composite novel anode materials for high performance Li-ion batteries
Authors: Pan Qiliang , Zhao Jianguo , Xing Baoyan , Jiang Shang , Pang Mingjun , Qu Wenshan , Zhang Shanshan , Zhang Yichan , Zhao Lu , Liang Wei
Published: August 2019

The excellent electrochemical properties are attributed to the synergistic action of hierarchical porous TiO2 and carbon layers.
Tuning the band gap of hybrid lead free defect perovskite nano crystals for solar cell applications
Authors: Ganesan R. , Vinodhini S. P. , Balasubramani V. , Parthipan G. , Sridhar T. M. , Arulmozhi R. , Muralidharan R.
Published: August 2019

In recent reports, combinations of lead free organic inorganic halide perovskites have shown significant advances in solar cell devices.
Plasmonic nanoparticle simulations and inverse design using machine learning
Authors: He Jing , He Chang , Zheng Chao , Wang Qian , Ye Jian
Published: August 2019

Ultrafast and computing resource-saving prediction of the far- and near-field optical properties of plasmonic nanoparticles and inverse design of their dimensions from the far-field spectra can be realized using machine learning.
Organic–inorganic nanoflowers: from design strategy to biomedical applications
Authors: Liu Yucheng , Ji Xinghu , He Zhike
Published: August 2019

This review summarized recent advances in organic–inorganic hybrid nanoflowers for versatile biomedical applications including bio-catalysis, biosensors and cancer therapy.
3D hollow Co–Fe–P nanoframes immobilized on N,P-doped CNT as an efficient electrocatalyst for overall water splitting
Authors: Li Wenxin , Chen Yuanfu , Yu Bo , Hu Yang , Wang Xinqiang , Yang Dongxu
Published: August 2019

The outstanding electrocatalytic performance of CoFeP NFs/NPCNT is attributed to its unique 3D hollow nanoarchitecture.
Mixing the valence control of Eu2+/Eu3+ and energy transfer construction of Eu2+/Mn2+ in the solid solution (1 − x)Ca3(PO4)2–xCa9Y(PO4)7 for multichannel photoluminescence tuning
Authors: Dang Peipei , Liu Dongjie , Li Guogang , Liang Sisi , Lian Hongzhou , Shang Mengmeng , Lin Jun
Published: August 2019

Multichannel photoluminescence control from blue-to-green to red across the white region was achieved by solid solution evolution, valence mixing of Eu2+/3+ and Eu2+ → Mn2+ energy transfer.
A sulfonate group functionalized active carbon-based Cu catalyst for electrochemical ammonia synthesis under ambient conditions
Authors: Zhang Shengbo , Li Wenyi , Liu Yanyan , Wang Jialu , Wang Guozhong , Zhang Yunxia , Han Miaomiao , Zhang Haimin
Published: August 2019

A copper-based catalyst supported by sulfonate group functionalized activated carbon shows superior NRR activity due to the suppressed hydrogen evolution reaction (HER) caused by the sulfonate group.
Tuning the electronic structure of PtRu bimetallic nanoparticles for promoting the hydrogen oxidation reaction in alkaline media
Authors: Long Chang , Wang Kun , Shi Yanan , Yang Zhongjie , Zhang Xiaofei , Zhang Yin , Han Jianyu , Bao Yini , Chang Lin , Liu Shaoqin , Tang Zhiyong
Published: August 2019

Alloying degree of PtRu bimetallic nanoparticles can be controlled to finely tune electronic effect for enhanced Hydrogen oxidation reaction in alkaline.
Spherical graphite produced from waste semi-coke with enhanced properties as an anode material for Li-ion batteries
Authors: Shi Ming , Tai Zige , Li Na , Zou Kunyang , Chen Yuanzhen , Sun Junjie , Liu Yongning
Published: August 2019

Spherical graphite produced from waste semi-coke displays an excellent cycle life with the capacity retention of 97.7% at 0.5C after 700 cycles.
Synergetic enhancement of polysulfide chemisorption and electrocatalysis over bicontinuous MoN@N-rich carbon porous nano-octahedra for Li–S batteries
Authors: Wang Peng , Li Na , Zhang Zhian , Hong Bo , Li Jie , Zhang Kai , Xie Keyu , Lai Yanqing
Published: August 2019

The schematic of the trapping effect of sulfur and LiPSs in MoN-NC and long-term cycling stability of 77S/MoN-NC electrode with different sulfur loading.
Layered cobalt hydrotalcite as an advanced lithium-ion anode material with high capacity and rate capability
Authors: Pan Long , Huang Haijian , Niederberger Markus
Published: August 2019

Layered cobalt hydrotalcite has been demonstrated as a conversion type anode material with high capacity and high rate capability for lithium-ion batteries.
Rapid advances in antimony triselenide photocathodes for solar hydrogen generation
Authors: Yang Wooseok , Moon Jooho
Published: August 2019

The advantages of antimony triselenide (Sb2Se3) over other semiconducting materials for solar-to-hydrogen conversion are highlighted. Rapid recent advances in Sb2Se3 photocathode technology are summarized and future research directions are discussed.
A ZnO–curcumin nanocomposite embedded hybrid collagen scaffold for effective scarless skin regeneration in acute burn injury
Authors: Kalirajan Cheirmadurai , Palanisamy Thanikaivelan
Published: August 2019

A nano-engineered hybrid collagen scaffold enables healing of severe burn injuries without the formation of scars by stimulating key bio-factors.
A fungal mycelium templates the growth of aragonite needles
Authors: Livne Achiya , Mijowska Sylwia Carolina , Polishchuk Iryna , Mashikoane Wilson , Katsman Alexander , Pokroy Boaz
Published: August 2019

Fungi live within diverse environments and survive well under extreme conditions that are usually beyond the tolerance of most other organisms.
Facile colorimetric detection of alkaline phosphatase activity based on the target-induced valence state regulation of oxidase-mimicking Ce-based nanorods
Authors: Song Hongwei , Ye Kun , Peng Yinxian , Wang Linjie , Niu Xiangheng
Published: August 2019

A novel ALP activity sensing strategy based on the target-induced valence state regulation of oxidase-mimicking Ce-based nanorods is proposed.
Rational molecular design for isoindigo-based polymer semiconductors with high ductility and high electrical performance
Authors: Tian Fengshou , Chen Han , Du Yuchang , Chen Junhui , Wang Xiaohong , Lu Hongbo , Cho Kilwon , Zhang Guobing , Qiu Longzhen
Published: August 2019

BIBDF monomers with enhanced local aggregation induced small area crystallization and enhanced intrinsic ductility and mobility.
In situ PTCDI-aided lateral crystallization of benzothieno-benzothiophene derivative for photoresponsive organic ambipolar devices
Authors: Tarsoly Gergely , Park Sunghwi , Pyo Seungmoon
Published: August 2019

Well-balanced, photosensitive ambipolar transistors were fabricated based on solution processed laterally stacked crystals from a mixed solution using PTCDI-C5 as n-type channel material and template for the crystallization of p-type C8-BTBT.
Novel approaches and scalability prospects of copper based hole transporting materials for planar perovskite solar cells
Authors: Bidikoudi Maria , Kymakis Emmanuel
Published: August 2019

A decade after their first appearance as components of solar cells, perovskites are still at the center of solar research.
Eco-friendly synthesis of glutathione-capped CdTe/CdSe/ZnSe core/double shell quantum dots: their cytotoxicity and genotoxicity effects on Chinese hamster ovary cells
Authors: Monaheng Neo Mervyn , Parani Sundararajan , Gulumian Mary , Oluwafemi Oluwatobi Samuel
Published: August 2019

In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay. The as-synthesised nanocrystals displayed good optical properties and were spherical in shape with an average particle diameter of 5.9 ± 1.13 nm. The intracellular uptake study showed that most of the as-synthesised glutathione stabilized QDs penetrated the cell membranes and were found randomly localized in the cytoplasm of Chinese Hamster Ovary (CHO) cells even at a lower concentration of 0.5 μg ml−1. The QDs showed no cytotoxicity to Chinese Hamster Ovary (CHO) cells at six concentrations tested (0.5, 1.0, 2.5, 5.0, 10, and 25 μg ml−1). However, at 50 and 100 μg ml−1 the material was cytotoxic at significant p values of 3.1 × 10−4 and 9.47 × 10−10, respectively. Likewise, the material was found to be genotoxic at almost all concentrations tested. The genotoxicity of the nanocrystals in question confers unfavorable potential to all complex heterostructured nanocrystals. Hence, more studies are needed to negate the prevailing assumption that multishell passivation provides enough protection against intracellular QD core dissolution or the production of reactive oxygen species (ROS) before these nanomaterials can be used in vivo for human health applications.
Étude de l’infestation des céréales par les nématodes à kyste « Heterodera spp. » et distribution des espèces en cause dans l’Ouest de l’Algérie
Authors: Assia Fatiha Righi , Righi Kada , Boungab Karima , Mokabli Aissa
Published: August 2019

L’extension des superficies céréalières dans l’Ouest de l’Algérie (plus de 1 million d’hectares depuis le littoral jusqu’aux régions sahariennes) s’est traduite par la manifestation de plusieurs bio-agresseurs dont les plus redoutables sont les nématodes à kyste des céréales. L’état actuel des infestations et celui de la distribution des espèces d’Heterodera dans cette région de l’Algérie fait l’objet de cette étude. L’analyse nématologique de 1787 prélèvements représentant 156 localités appartenant à 12 willayas a permis de conclure que ces nématodes sont présents dans 53 % des échantillons. La fréquence de l’infestation varie entre 48 et 51 % selon les régions et peut atteindre localement 100 %. Ces infestations sont causées par cinq espèces : Heterodera avenae, H. latipons, H. hordecalis, H. filipjevi et H. mani qui se rencontrent en populations pures ou mélangées. H. avenae est l’espèce dominante dans 50 % des relevés, suivie par H. latipons qui se trouve dans 34 % des localités prospectées et 33 % des echantillons prélevés. Heterodera mani, qui est parfois devancée par H. hordecalis ou H. filipjevi dans certaines localités, prend souvent la troisième place (7 %). Elle est présente dans 34 relevés soit un taux de 4 %. H. hordecalis, espèce inféodée surtout à l’orge, se classe quatrième et a été signalée dans 6 % des localités (35 relevés soit 4 %). H. filipjevi, espèce très proche d’H. avenae, semble s’étendre, avec des taux variables selon les localités. Sa présence est marquée dans 2 % des localités et dans 3 % des relevés (19 relevés). La réalisation des cartes d’infestation et de distribution pour certaines régions, à savoir Mascara, Relizane et Sidi Bel Abbès, pourrait permettre d’élaborer un outil d’aide à la décision à même de faciliter la surveillance et la gestion de ce risque phytosanitaire en temps opportun.
Domain decomposition and multiscale mortar mixed finite element methods for linear elasticity with weak stress symmetry
Authors: Khattatov Eldar , Yotov Ivan
Published: August 2019

Two non-overlapping domain decomposition methods are presented for the mixed finite element formulation of linear elasticity with weakly enforced stress symmetry. The methods utilize either displacement or normal stress Lagrange multiplier to impose interface continuity of normal stress or displacement, respectively. By eliminating the interior subdomain variables, the global problem is reduced to an interface problem, which is then solved by an iterative procedure. The condition number of the resulting algebraic interface problem is analyzed for both methods. A multiscale mortar mixed finite element method for the problem of interest on non-matching multiblock grids is also studied. It uses a coarse scale mortar finite element space on the non-matching interfaces to approximate the trace of the displacement and impose weakly the continuity of normal stress. A priori error analysis is performed. It is shown that, with appropriate choice of the mortar space, optimal convergence on the fine scale is obtained for the stress, displacement, and rotation, as well as some superconvergence for the displacement. Computational results are presented in confirmation of the theory of all proposed methods.
Liquid structure evolution of molten iron in blast furnace hearth
Authors: Deng Yong , Jiao Kexin , Zhang Jianliang
Published: August 2019

The iron-carbon interfacial reaction between molten iron and carbon brick was carried out to simulate the working condition of blast furnace (BF) hearth. The carbon content in molten iron after the reaction was detected to be 5.0% which was almost saturated. XRD and SEM-EDS were conducted on the surface of polished rectangle iron before and after iron-carbon interfacial reaction. Fine striped graphite was observed in iron before iron-carbon interfacial reaction, a large amount of flake-like graphite was observed in iron after iron-carbon interfacial reaction. As a structure-sensitive physical property, the viscosity of molten iron was the macroscopic expression of its liquid structure. The liquid structure of molten iron (Fe-4.5%C, Fe-5.0%C) was measured through a high temperature X-ray diffractometer. The X-ray original diffraction intensity, the structure factor, the pair distribution function, the radial distribution function, and the main parameters of molten iron were obtained through the calculation. The presence of pre-peak in the structure factor indicated that there was a medium-range order in molten iron, some compounds or cluster of atoms might exist in molten iron, the structure model of atoms in liquid Fe-4.5%C was predicted through the structure parameters. The increase of carbon content after iron-carbon interfacial reaction was the essential reason for liquid structure evolution of molten iron in hearth.
The World Building Framework for Immersive Storytelling Projects
Authors: Breuleux Yan , de Coninck Bruno , Therrien Simon
Published: August 2019

This article explores issues associated with immersive storytelling in order to examine how the field of World Building can constitute a theoretical framework for practice in the context of VR-based and Full Dome artistic projects. With respect to immersion, the intent will be to interpret the concept of storytelling in relation with the recent formulation of the concept of extended reality (XR). The very concept of World Building is transauthor and transmedia by nature. The transauthor dimension of World Building resides in the idea of subcreation, i.e., designing environments and interaction rules that help create a storytelling basis for generating multiple stories. Once the universe has been conceived, stories written by different authors take shape through transmedia processes across multiple distribution media (film, video games, web, etc.). The question then arises: How can the World Building approach shape the construction of immersive experiences? The article sets out to answer this question, and in doing so, to contribute to the research on environmental storytelling.
Exploring territories by documentary: The appropriation of public spaces by collective listening
Authors: Roça Luciana , Martins Maria J.S. , Tramontano Marcelo
Published: August 2019

Sound has a relational interplay with space, influencing the arrangement of ephemeral and symbolic territories in public spaces. Within this perspective, this article aims to discuss the influence of collective listening in the appropriation of public spaces, discussing the events conducted spontaneously by the youth in the Coronel Salles Square, Sao Carlos, Brazil. Weekly on Fridays, this marginalised community builds an ephemeral territory in the square, which is also influenced by collective listening by powerful speakers in cars. As methods, we use documentary procedures to take a closer look at these events. Being an assertion of the historical world, a perspective is taken by a non-neutral part, a documentary performed as practice-as-research offers a useful set of methods to researchers to explore urban issues and matters and, it is a reflexive method which questions the researcher’s posture.
Urban visions: Back from the future
Authors: Chamel Olivier
Published: August 2019

The persistent growth of the human civilization, fueled in large part by technological progress has brought upon us a series of very serious challenges. The quality of our overall environment, energy and food supply are subjected to increased pressure, while access to decent employment, housing and medical care remains broadly unequal. According to the current trends most of the world’s future population growth will occur in cities, therefore positioning the city as a key component to solving challenges associated with human development. Based on that assumption, it seems crucial to think about what the city of the future should be and look like. If we look for existing and graphically convincing representation of the city of the future, we are inevitably drawn to popular culture media such as movies and graphic novels. For almost a century, movies in particular have proposed realistic constructs of future urban settlements along with the life associated with them. Based on a number of ideas expressed in motion pictures over the years about urban life in the future, one can argue that both past and recent predictions tend to be technologically optimistic but socially and environmentally pessimistic. This paper proposes to identify and discuss a number of challenges as well as opportunities associated with urban development in the next 100 to 200 years and present a series of urban visions to illustrate both positive and negative trends.
Embraced by swirls of ether. Atmospheric imagination and the representation of assimilation and effect
Authors: Elvira Juan
Published: August 2019

Atmospheres have a diffuse, ungraspable nature that make them problematic to represent. Diverse artistic manifestations have relentlessly tried to grasp air infused with properties. Ether is the concept chosen to test the way the history of atmospheric representation was initiated; a cultural artefact whose representation permeates our present imaginary. Such substance has been the image of sensual assimilation, of psychological life and complex ambient effects. Before ambient was subject to technical representation, images of air within can be called ‘a state of animation’ opened up the ways of seeing and producing ambients. Several case studies are analysed as a useful vehicle for atmospheric representation. Two main strategies have been identified. The first one is the representation of chance, ambiguity and openness, the creation of conditions to let atmospheres leave its accidental traces. The second consists in the precise distribution in space of particles or discrete elements whose initial position is irritated by diverse agents. Both are still recognisable in our days.
Architecture as Landscape
Authors: Abbas Yasmine
Published: August 2019

This study constitutes the latest reflection on pedagogical research and experimental pedagogical projects involving the representation, design, and computation of ambiances. Led by the author at various architecture schools in France, Japan, and the United States, these creative explorations involving drawings and models offer ways to realize, feel, and fabricate architecture. The projects described were conducted in 2018 in courses offered by the Department of Architecture, Stuckeman School, College of Arts and Architecture at the Pennsylvania State University. They show that architectural productions are not static objects, but instead render a dynamic landscape itself nested within a changing milieu. Through these projects, by looking closely at the parameters of spatial effects, students engaged in processes of design taking movement into account in meaningful ways.
Studio_ L28: From a Socially Engaged Sound Art Practice to an Open Training Ground for Sonic Design Experimentation
Authors: Claus Caroline , Pak Burak
Published: August 2019

This paper reflects the preliminary findings of a PhD research on the spatial politics and potentials of noise and vibration, and the affective or attractive and repulsive power of sonic force. We focus on the public space of a railway area in transformation in Brussels, where sonic conflicts are prevalent. To explore the affordances of a sonic urbanism as critical spatial practice and thus to break free from prevailing modes of urbanism which focus on sonic risk and vibrational nuisance − we constitute a working practice exploiting and nurturing the productive encounters between disciplines such as sound art, urbanism and urban architecture. By setting up an experimental design studio at the KU Leuven Faculty of Architecture, embedded in local auditory culture and in connection to ongoing planning processes, we aimed to facilitate an open learning ground for sonic design experimentation in the development of innovative sonic spatial tools and approaches. The studio was oriented to students of the International Master in Architecture summoned to research the multiple (sonic) vibrations of the L28 railway area, to exploit and contrast these vibrational forces, transforming them to into actions and opportunities. From a critical sonic understanding of urban space, students played and explored a contradictory role compared to the widespread noise control practices, reformulated environments, perimeters and relations of urban phenomena and searched for interactivity with vibrational dynamics that already exist in the territory.
Envisioning the atmospheric effect through (im)materiality
Authors: Ünsal Gülmez Nilay , Atılgan Yagan Dürnev , Şahin Murat , Ekenyazıcı Güney Efsun , Tulum Hande
Published: August 2019

In an attempt to bridge the gap between architectural/interior design practice and education, ‘atmosphere’ as a prolific contemporary architectural debate in practice and theory is covered by the experiment of ‘Staging Poe’ carried out as a first year Design Studio through the study of Edgar Allen Poe’s selected poems. Poe’s 1846 text of ‘The Philosophy of Composition’, unfolding his analytical method of writing and emphasis on “effect” in poetry, provides a ground for experimenting with facets of materiality and structuring the studio. Aiming to cultivate intuitive design experiments of students into informed processes in hybridizing conceptual/textual and material/sensual aspects, studio is structured in two phases. In the first phase, “materialization”, idiosyncratic interpretations of students from words to materials with a focus on tectonic experiments and haptic experiences are sought in between materializing and dematerializing processes. In the second phase, the “atmospheric”, emphasis on dematerialization of the perception of materials through tools, such as light, color and sound is exercised to transform the object into a performance stage. Outcomes of the studio on aspects pertaining to material and materialities in creation of the immaterial that is the atmosphere is followed and evaluated through responses of students’ weekly reports.
Community-based grassroot communication strategies, process and product: The drawings that saved our hospital
Authors: Mounayar Michel
Published: August 2019

A case-study analysis of an urban design communication strategy employed by our university-based design team entrusted with re-envisioning the uncertain future of a local small-town community hospital in Indiana. The design process is carefully constructed from structured public input, and community participation, whereby students, faculty, physicians, nurses, as well as ordinary citizens combine their efforts to strategically develop their ‘plan for planning’. Finding a strategy to define the scope of their future needs and the definition of important priorities to organize the project scope prior to engaging professional consultants. In this scenario, the design team is only the guide and translator, working closely with stakeholders to help them visualize and clarify the aspirations of their town. This paper will present our community-based design methods and most importantly our graphic communication techniques, specifically formulated to envision and facilitate consensus for a new unified public health system in a small Midwestern American city.
Out of “touch”? − An experiential pedagogical approach to daylighting in architecture and interior design education
Authors: Treacy Gillian
Published: August 2019

A new challenge is emerging. Contemporary built environment pedagogy demands engagement with both analogue and digital tools for simulation and verification of lit architectural environments. The use of analogue tools within architectural design education grasps onto the historically valued craftsmanship of drawing and physical models to measure, represent and understand our lit environment ambiance. Digital tools can provide efficient, simultaneous and precise verification of lit architectural interior space through 3D computer modelling and calculation software. However, the understanding and representation of daylit scenarios is becoming more numerically complex as lighting metrics and software gain in accuracy and dynamic range. With the majority of easily accessible software tools focussing on numerical verification, the ephemeral ambience that daylight in particular creates in interior architectural spaces is becoming ever more difficult to grasp for the architectural design student and practitioner. This paper seeks to challenge the exclusive use of digital tools for the understanding and representation of lit interiors by proposing that this methodology cultivates design epistemologies that are out of “touch”. Questionnaire findings and workshop studies are presented as pedagogical constructs are proposed inviting physical, experiential learning of lighting principles in collaboration with numerical and digital modes of learning to provide connections and translations to develop through ‘touch’ing light.
Experiential Simulation and Psychological assessment as a learning process in architectural higher education
Authors: Piga Barbara E. A. , Rainiso Nicola , Boffi Marco
Published: August 2019

This paper presents the advancements of an applied methodology developed by the authors, namely an architect and two environmental psychologists, based on Virtual Reality coupled with psychological surveys − developed ad hoc by the authors − for urban design; in particular, the paper discusses its application in the field of architectural higher education. The proposed method is based on the pre-evaluation of people’s urban experience for testing the effectiveness of design solutions, discovering the unforeseen, and reducing the risk of failure. The method connects architectural to psychological approaches and investigations. The procedure can be schematized as follows: (1) final users navigate the simulation of the design scheme and feedback is collected; (2) the analysis of these collected data is run by professionals and discussed with the designers that then develop the final design solution. In this contribution, we illustrate the application to the urban design development carried out by 100 students of the last year of the Master of Science in Architecture and Urban Planning working in groups. The paper will firstly synthetically present the overall research; secondly, it will argue about its application for higher education; finally, it will conclude by describing the pros and cons of the experimentation, especially in relation to the whole learning and maieutic process and its impact on the design solutions adopted by students, with a focus on the experiential multisensory design.
Educational XRealities
Authors: Stellingwerff Martijn
Published: August 2019

XRealities is a recently approved pedagogic fellowship project that will run for two years, during 2019 and 2020. This paper will introduce the project plan, some early experiments and expectations. XRealities relates to the many real and digital situations that we encounter in our digitally expanded life experiences. In contemporary education, we notice a problematic situation with abundant screens. People sit next to each other and stare at screens, looking for contact and content. We describe the current dichotomy between latent online learning materials and potential real-world experiences in campus education. The XRealities project is focused on finding alternative approaches for educational settings in which both real- world social interactions and virtual content provide new forms of intertwined learning experiences. We assume there is huge educational potential in the right juxtaposition of visual digital and real-world experiences and the embodied interaction within this augmented reality.
Optimaler Schutz für die Hände
Authors: Nadler Sylvia
Published: August 2019

Die Hände sind das wichtigste Instrumentarium des OP-Personals und müssen deshalb
gut geschützt werden. Obwohl die meisten OP-Handschuhe ausreichend Schutz bei
den gängigen Anwendungen bieten, können von den Handschuhmaterialien
unterschiedliche Risiken für den Träger sowie für Patienten ausgehen. Unsere
Autorin erklärt, welche Aspekte bei der Auswahl des richtigen Handschuhs zu
beachten sind.
Verzögerungen im OP-Ablauf
Authors: Wellhöfer Denise
Published: August 2019

Wenn eine OP nicht pünktlich startet, ist das häufig auf eine Verkettung
zahlreicher Umstände zurückzuführen. Doch wie wirken sich Verzögerungen im
OP-Ablauf auf das Erleben von Patienten und Pflegenden aus? Dazu hat unsere
Autorin im Rahmen ihrer Bachelorarbeit Pflegekräfte befragt. Ihre Erkenntnisse
zu den Ursachen und Auswirkungen von OP-Verzögerungen hat sie in diesem Artikel
zusammengefasst. Außerdem gibt sie Empfehlungen, wie sich Wartezeiten verhindern
oder überbrücken lassen.
Epidemiology and Treatment of Patients with Haemophilia in Austria—Update from the Austrian Haemophilia Registry
Authors: Rejtő Judit , Reitter-Pfoertner Sylvia , Kepa Sylvia , Feistritzer Clemens , Grundbichler Michael , Hörbst Alexander , Jones Neil , Muntean Wolfgang , Neumeister Peter , Oberbichler Stefan , Schuster Gerhard , Schwarz Rudolf , Thom Katharina , Zwiauer Karl , Streif Werner , Male Christoph , Pabinger Ingrid
Published: August 2019

The Austrian Haemophilia Registry collects epidemiological data on patients with haemophilia, on treatment modalities and potential side effects. The Registry covers more than 85% of the assumed total number of haemophilia patients in Austria. This report summarizes data on 753 patients: 84.3% (635) have haemophilia A and 15.7% (118) have haemophilia B. Patients' median age is 34 years (range: 1–93 years). Of the total cohort, 39.0% (294) patients have severe haemophilia, 11.3% (85) moderate haemophilia, and 49.4% (372) mild haemophilia. Of the patients with severe haemophilia, 38.4% (113) have been infected with hepatitis C virus (HCV) and 12.6% (37) are human immunodeficiency virus (HIV) positive. Overall, 10.6% (67) of patients with haemophilia A and 1.7% (2) of those with haemophilia B have had an inhibitor in their history. Among patients with severe haemophilia, 68.4% (201) receive prophylaxis and 28.6% (84) receive on-demand therapy. There are 65.0% (191) patients with severe haemophilia who are treated with recombinant products. In conclusion, most patients with severe haemophilia receive prophylactic treatment. HCV and HIV infections are still important issues in the Austrian haemophilia population.
A Multifunctional HBED-Type Chelator with Dual Conjugation Capabilities for Radiopharmaceutical Development
Authors: Makarem Ata , Sarvestani Mohammadreza Kamali , Klika Karel D. , Kopka Klaus
Published: August 2019

Bifunctional HBED chelators are hexadentate complexing ligands (chelators) that tightly coordinate to trivalent gallium and, additionally, are able to bind to bioactive molecules. In nuclear medicine, HBED-based radiopharmaceuticals are used as powerful radiotracers for tumor imaging. Among variants of bifunctional HBED chelators, HBED-CC is the most well-known; it possesses two terminal carboxylic acid groups that are able to undergo bioconjugation by amide-bond formation. However, to permit bioconjugation through click coupling, we previously modified the structure of HBED-CC and introduced HBED-NN chelator bearing two azide functions. We have now combined the conjugation capabilities of HBED-CC and HBED-NN chelators in one molecule and have created HBED-NC, which possesses both azide and carboxylic acid groups. The advantage of HBED-NC is that it provides options for constructing either monomeric or heterodimeric radiolabeling precursors. This work describes the synthesis of HBED-NC by either of two pathways.
Recuperação do centro de rotação do quadril com tântalo em artroplastias de revisão
Authors: Barros Antônio Augusto Guimarães , Barbosa Victor Atsushi Kasuya , Costa Lincoln Paiva , Guedes Euler de Carvalho , Vassalo Carlos César
Published: August 2019

Objetivo O objetivo do presente estudo é avaliar a capacidade de restauração do centro de rotação anatômico do quadril com uso de copas acetabulares de tântalo associado ou não a cunhas de adição.

Métodos Análise retrospectiva dos pacientes submetidos a revisão de artroplastia do quadril com uso de tântalo entre o período de junho de 2013 e abril de 2017. Foram avaliados o ângulo de abdução do componente acetabular e as distâncias horizontal e vertical do componente ao centro de rotação anatômico do quadril. As medidas foram realizadas através de radiografias da bacia realizadas no pré-operatório e na última visita de seguimento.

Resultados Obteve-se uma amostra de 21 pacientes, 11 (52%) homens e 10 (48%) mulheres, com média de idade de 62 ± 13 anos. O ângulo médio de abdução da copa acetabular reduziu de 48,76° ± 13,88° no pré-operatório para 38,52° ± 10,08° no pós-operatório, sendo esta diferença estatisticamente significativa (p = 0,001). As distâncias do centro de rotação da prótese em relação ao centro de rotação anatômico do quadril também foram menores após a cirurgia de revisão com o tântalo. A distância média horizontal de 12,74 ± 10,59 mm foi reduzida para 7,11 ± 4,84 mm, e a distância média vertical foi reduzida de 14,79 ± 10,05 mm para 4,89 ± 6,21 mm, sendo essas reduções estatisticamente significativas (p < 0,001).

Conclusão As revisões de artroplastia do quadril com copas de tântalo, associadas ou não a cunhas de adição, recuperaram de forma significativa o centro de rotação anatômico do quadril.
Femoral Hernia Containing the Right Fallopian Tube: A Rare Finding
Authors: Viveiros Duarte , Lázaro André , Carvalho Hélder
Published: August 2019

Femoral hernias comprise a small proportion of all groin hernias. They are more common in women and have a high rate of incarceration and strangulation, leading to emergency repair. A 61-year-old female patient was admitted to the emergency department complaining of a 2-day painful lump in the right groin, that had become more intense in the last 24 hours. Physical examination suggested the presence of a strangulated femoral hernia, and the patient underwent emergency surgical repair. Intraoperatively, the right fallopian tube was observed in the hernia sac. Since there were no signs of ischemia, the tube was reduced back into the pelvic cavity and the hernia was repaired. The postoperative period was uneventful, and the patient was discharged without complications, 3 days after surgery.
Avaliação do perfil laboratorial de idosos com fratura de fêmur proximal por mecanismo de baixa energia
Authors: Baggio Marcelo , Oliveira Daniel Teixeira de , Locks Renato
Published: August 2019

Objetivo Avaliar o perfil laboratorial de idosos com fratura de fêmur proximal e verificar a relação dos dados com o desfecho da própria fratura e com o desfecho óbito.

Métodos Estudo transversal de pacientes admitidos na emergência ortopédica de um hospital referência, entre os meses de fevereiro e abril de 2017, com fratura de fêmur proximal, por mecanismo de baixa energia, sendo coletados exames laboratoriais e de imagem. Foram excluídos do estudo pacientes com suspeita ou confirmação de fratura patológica.

Resultados Foram avaliados 66 indivíduos, sendo 44 mulheres, todos com idade superior a 60 anos. A fratura transtrocantérica apresentou maior incidência no estudo (36). Alterações do hormônio da paratireoide (PTH) e da albumina foram significativos para óbito (p ≤ 0,05). O tempo de internação não foi fator significativo para óbito.

Conclusões Alterações laboratoriais não estavam relacionadas ao desfecho de óbito. A albumina pode estar relacionada ao risco de óbito. Nenhum resultado laboratorial foi apontado como facilitador na geração de fraturas de fêmur proximal. Mais estudos são necessários para poder entender melhor a influência do quadro laboratorial do paciente na ocorrência de fraturas e suas consequências.
Effectiveness of Solution-Focused Group Counseling on the Mental Health of Midwifery Students
Authors: Javid Nezhat , Ahmadi Atefeh , Mirzaei Moghadameh , Atghaei Monavvareh
Published: August 2019

Objective The present study was conducted with the objective of investigating the effectiveness of solution-focused group counseling (SFGC) on promoting the mental health of midwifery students.

Methods The present study is an intervention-based study with a pretest, a post-test, and a control group. The statistical population included all of the midwifery students studying in the midwifery department of the Bam University of Medical Sciences, Kerman, Iran, who filled out the General Health Questionnaire (GHQ) in the screening phase. In the second phase, 40 individuals, having a low level of mental health based on the cutoff score of 23, were selected and randomly divided into 2 groups (intervention and control), each group with 20 participants. The intervention group participated in 5 sessions of 75 minutes for SFGC. Then, the post-test was held in both groups and the data analysis was conducted using the Mann-Whitney and the Kruskal-Wallis test with IBM SPSS Statistics for Windows, Version 21.0 (IBM Corp, Armonk, NY, USA). The significance level was considered as p < 0.05.

Results The findings showed that the mean of the post-test mental health scores of the intervention group (14.5 ± 50.35) and of the control group (23.6 ± 35.83) showed a statistically significant difference (p < 0.0001). Moreover, the comparison between the mean scores of the mental health subscales (physical symptoms, stress, social performance, and depression) showed a statistically significant difference in these groups, and SFGC improved physical symptoms, stress, social performance, and depression in the members of the intervention group.

Conclusion Solution-focused group counseling may improve all levels of mental health. This type of counseling is recommended to be used to solve the psychological problems and to improve the mental health of students, as well as of the staff of the health system.
Efeito das posições dos enxertos na estabilidade da artroplastia total de quadril com diferentes tipos de encurtamento subtrocantérico
Authors: Yazar Ethem Aytac , Karakus Ozgun , Saygi Baransel
Published: August 2019

Objetivo O objetivo do presente estudo é investigar a estabilidade biomecânica de diferentes tipos de osteotomias subtrocantéricas e posições de enxertos em coxartroses displásicas que necessitam de artroplastia total de quadril com osteotomia de encurtamento, e determinar o tipo de osteotomia e a posição do enxerto que são mais eficazes.

Método Modelos de fêmur (sawbones) foram usados para comparar os tipos de osteotomia de encurtamento femoral (transversal, oblíqua e em degrau de escada [step-cut]). Os enxertos em haste, preparados do lado da osteotomia subtrocantérica, foram fixados em diferentes posições (ântero-lateral, medial-lateral e ântero-posterior). A fixação dos enxertos foi feita com 2 cabos de aço (de 2,0 mm de largura) de mesma resistência. Os valores de falha dos fêmures compostos para cargas axiais e rotacionais foram registrados.

Resultados Do ponto de vista biomecânico, não houve diferenças estatisticamente significativas entre os tipos de osteotomia de encurtamento subtrocantérico femoral e as posições dos enxertos em haste aplicados.

Conclusão Não houve superioridade entre os tipos de osteotomia de encurtamento subtrocantérico femoral quanto à estabilidade. Além disso, em relação à resistência ao estresse, os resultados obtidos com diferentes posições das hastes foram similares. Assim, acreditamos que o método mais indicado é aquele em que o cirurgião é experiente e cuja aplicação é mais fácil.
O tamanho dos implantes atualmente disponíveis para a artroplastia total do quadril está adequado à nossa população?
Authors: Busato Thiago Sampaio , Barbosa Gabriella Maira Rodrigues , Velho Anderson Emanuel Kumandala , Matioski Filho Gladyston Roberto , Godoi Lucas Dias , Capriotti Juan R.V.
Published: August 2019

Objetivo Definir se as dimensões de alguns implantes de fabricação nacional e estrangeira utilizados nas cirurgias de artroplastia do quadril estão adequadas ao perfil antropométrico da população brasileira.

Métodos Estudo retrospectivo de pacientes submetidos a cirurgia primária de substituição artroplástica total do quadril. Foram excluídos deste estudo pacientes com alterações morfológicas femorais ou acetabulares que pudessem influenciar na escolha do tamanho dos implantes, tais como sequelas de displasia, trauma, entre outras. Foram incluídos neste estudo dois implantes de fabricação nacional e seis modelos importados. Todos os pacientes foram operados pela mesma equipe, por um dos quatro autores seniores ou sob sua supervisão direta, seguindo a mesma técnica cirúrgica. Os dados foram estatisticamente analisados em relação a gênero, idade, tipo de fixação e modelo dos implantes.

Resultados A análise estatística de 682 quadris submetidos a artroplastia total demonstrou que 2 modelos de hastes femorais cimentadas e 1 de haste não cimentada não estão perfeitamente adequados à morfologia femoral da população estudada, pois, na maioria dos casos, nestes 3 implantes, foi utilizado o menor tamanho disponível, resultando em uma curva não gaussiana. O diâmetro médio do acetábulo nativo foi de 54 mm nos homens e de 52 mm nas mulheres.

Conclusão Dos oito modelos estudados, cinco se mostraram adequados à população estudada. Outros três modelos disponíveis em nosso mercado (dois nacionais e um importado) parecem necessitar de um escalonamento mais adequado. Destacamos que são necessários estudos antropométricos do quadril da população brasileira para dar subsídios científicos ao desenho ideal dos implantes para o nosso mercado.
A Report of a Novel Pathogenic Variant in a Family with Buschke–Ollendorf Syndrome
Authors: Jain Angita , Selvam Pavalan , Atwal Herjot , Atwal Paldeep S.
Published: August 2019

Buschke–Ollendorf Syndrome (BOS) is a benign autosomal dominant disorder caused by pathogenic mutations in LEMD3. Here, we describe a family diagnosed to have varied phenotypes associated with BOS. Single gene testing of LEMD3 detected a heterozygous frameshift pathogenic variant in both the affected family members. Besides the phenotypic description, this report highlights the need for a comprehensive evaluation in connective tissue disorders and the importance of genotype–phenotype correlation in BOS.