bluuebunny/crossref_metadata_2025 huggingface dataset:
RELATIONS BETWEEN STATE BODIES AND TRADE UNIONS OF SIBERIA (1918—1929)
Authors: Baksheev A. I.
Published: February 2020

The problems of the trade union movement are multidimensional and each state has its own characteristics related to the cultural and historical past of nations, traditions, ethnic composition of the population, level of economic development of the state, its territorial communities, etc. Along with the specific features of trade union organizations, theory and practice defined relatively well-established principles of forming trade unions and their tasks, which can be used in the further development of the state, including in today’s Russia. In this regard, the development of relations between trade unions and state structures of Siberia in the 1920s is of great importance. Twentieth century. It was at this time that new areas of work of trade union bodies associated with the development of the Soviet state system are growing and gaining strength. This includes the nomination by the trade unions of candidates for leadership, above all economic, positions and uncritical support by the trade unions of any proposals from managers of enterprises and the abandonment of the struggle for workers’ rights in state enterprises, etc. Thus, Russia began the process of merging trade union organizations with the Soviet state. The reluctance of the trade unions to draw a clear distinction between their duties and the role of the appendages of economic bodies in production had a painful effect on relations with the workers. Such a position of the trade unions separated them from the real needs and demands of the workers, caused frustration and apathy of the population towards the trade union movement.
Impact of Prebiotics on Enteric Diseases and Oxidative Stress
Authors: Gao Jing , Azad Md A.K. , Han Hui , Wan Dan , Li TieJun
Published: February 2020

In animals, the gastrointestinal microbiota are reported to play a major role in digestion, nutrient absorption and the release of energy through metabolism of food. Therefore, microbiota may be a factor for association between diet and enteric diseases and oxidative stress. The gut microbial composition and concentration are affected by diet throughout the life of an animal, and respond rapidly and efficiently to dietary alterations, in particular to the use of prebiotics. Prebiotics, which play an important role in mammalian nutrition, are defined as dietary ingredients that lead to specific changes in both the composition and activity of the gastrointestinal microbiota through suppressing the proliferation of pathogens and by modifying the growth of beneficial microorganisms in the host intestine. A review of the evidence suggests possible beneficial effects of prebiotics on host intestinal health, including immune stimulation, gut barrier enhancement and the alteration of the gastrointestinal microbiota, and these effects appear to be dependent on alteration of the bacterial composition and short-chain fatty acid (SCFA) production. The production of SCFAs depends on the microbes available in the gut and the type of prebiotics available. The SCFAs most abundantly generated by gastrointestinal microbiota are acetate, butyrate and propionate, which are reported to have physiological effects on the health of the host. Nowadays, prebiotics are widely used in a range of food products to improve the intestinal microbiome and stimulate significant changes to the immune system. Thus, a diet with prebiotic supplements may help prevent enteric disease and oxidative stress by promoting a microbiome associated with better growth performance. This paper provides an overview of the hypothesis that a combination of ingestible prebiotics, chitosan, fructooligosaccharides and inulin will help relieve the dysbiosis of the gut and the oxidative stress of the host.
Synthesis of New Tetra Triazole Functionalized Calix[4]resorcinarene and Chemosensing of Copper Ions in Aqueous Medium
Authors: Qadri Tahir , Ali Imdad , Hussain Mumtaz , Ahmed Farid , Shah Muhammad R. , Hussain Zahid
Published: February 2020

A new tetra triazole functionalized calix[4]resorcinarene macrocycle (5) is synthesized
and utilized for the detection of copper ions in the aqueous medium. The photophysical
potential of compound (5) is examined by a range of cations (Ba2+, Ca2+, Co2+,
Hg2+, K+, Mg2+, Mn2+, Na+, NH4
+ and Pd2+). The triazole based calix[4]resorcinarene macrocycle
(5) has interacted with Cu2+ ion in preference of other cations. A significant
quenching has been observed after the addition of 15 μM Cu2+ ion solution, which produced
4.2 folds drift in the absorption intensity of compound (5). Tetra triazole functionalized
calix[4]resorcinarene macrocycle showed high selectivity towards copper ion chemosensing
without any interference in competitive studies. The pH studies of compound
(5) with Cu2+ indicated the maximum chelation between 7- 7.5 pH. The compound (5) is
capable to recognize Cu2+ at 1 μM detectable limit. Copper ion was detected in tap water with 15 μM concentration.
Job’s plot showed 1:2 binding ratio between macrocycle (5) and Cu2+.
MiR-101 Attenuates Myocardial Infarction-induced Injury by Targeting DDIT4 to Regulate Autophagy
Authors: Li Qiulan , Gao Yanping , Zhu Jie , Jia Qingzhe
Published: February 2020

Background:

Myocardial Infarction (MI), a kind of heart deficiency, is the main cause
of death and disability. Autophagy, a metabolic process for the degradation of damaged proteins or
organelles, is important for cardiac functions and regulated by several miRNAs including miRNA-
101. The aim of this research was to investigate the effects of miR-101 in myocardial infarctioninduced
injury and the related mechanisms.

Methods:

MI model was induced by ligation of the left coronary artery. The in vitro model was established
by hypoxia-induced H9c2 cells (rat myocardial cells). The overexpression of miR-101
was achieved by transfection. The expression of associated proteins was analyzed by Western blotting.
The level of miR-101 was analyzed by reverse transcription-polymerase chain reaction (RTPCR).
The target genes for miR-101 and the target sites were analyzed by TargetScan.

Results:

The results showed that miR-101 was decreased in MI mice (P<0.01). Autophagy and
apoptosis were increased in MI-induced injury (in vivo) and in hypoxia treated myocardial cells (in
vitro) (P<0.01). miR-101 overexpression inhibited the increase of autophagy and apoptosis in mice
and myocardial cells (P<0.01). DDIT4 was a target gene of miR-101 and expressed increasingly in
MI-induced injury mice and hypoxia treated myocardial cells. miR-101 could negatively regulate
the expression of DDIT4.

Conclusion:

This research suggested that miR-101 attenuated- MI-induced injury by targeting
DDIT4 to regulate autophagy, which indicated that miR-101 or DDIT4 may be potential therapeutic
targets for heart injury.
Interactions between Personality, Depression, Anxiety and Cognition to Understand Early Stage of Alzheimer’s Disease
Authors: Zufferey Valérie , Gunten Armin von , Kherif Ferath
Published: February 2020

The multifaceted nature of Alzheimer’s disease (AD) and Mild cognitive impairment (MCI) can lead to wide inter-individual differences in disease manifestation in terms of brain pathology and cognition. The lack of understanding of phenotypic diversity in AD arises from a difficulty in understanding the integration of different levels of network organization (i.e. genes, neurons, synapses, anatomical regions, functions) and in inclusion of other information such as neuropsychiatric characteristics, personal history, information regarding general health or subjective cognitive complaints in a coherent model. Non-cognitive factors, such as personality traits and behavioral and psychiatric symptoms, can be informative markers of early disease stage. It is known that personality can affect cognition and behavioral symptoms. The aim of the paper is to review the different types of interactions existing between personality, depression/anxiety, and cognition and cognitive disorders at behavioral and brain/genetic levels.
Syringic Acid: A Potential Natural Compound for the Management of Renal Oxidative Stress and Mitochondrial Biogenesis in Diabetic Rats
Authors: Rashedinia Marzieh , Khoshnoud Mohammad Javad , Fahlyan Bahman khalvati , Hashemi Seyedeh-Sara , Alimohammadi Mahshid , Sabahi Zahra
Published: February 2020

Background:

Diabetic nephropathy can lead to renal diseases; oxidative stress and mitochondrial
dysfunction have critical roles in its development.

Objectives:

In this study, the effect of syringic acid (SYR), a natural phenolic acid, on diabetic
nephropathy and mitochondrial biogenesis was examined.

Methods:

Diabetes was induced in rats by injecting streptozotocin. SYR (25, 50 and 100
mg/kg/day) was orally administered for 6 weeks. SYR effects on factors, such as antioxidant activities
and mRNA expression level of mitochondrial biogenesis indexes, were evaluated.

Results:

In SYR-treated rats, blood glucose and ALP level were significantly reduced. SYR
increased kidney GSH content in the diabetic group. Elevated renal catalase and superoxide dismutase
activities in diabetic rats were restored to normal levels after treatment. SYR significantly
reduced the renal TBARS level, which had increased in diabetic rats. This compound also significantly
upregulated renal mRNA expression of PGC-1α and NRF-1, and increased mtDNA/nDNA
ratio in diabetic rats. These values were reduced in the non-treated diabetic group. The results
show improvement of histopathological damages of kidney in the SYR treated group in comparison
with the diabetic group.

Conclusion:

According to the results, SYR alters renal antioxidant defense mechanisms. Also, it
could be considered as a novel approach by targeting mitochondria in renal diabetic complications.
Lifestyle Modification with Physical Activity Promotion on Leptin Resistance and Quality of Life in Metabolic Syndrome - A Systematic Review with Meta-Analysis
Authors: Parameshwar Anche , Maiya G. Arun , Kamath Shobha Ullas , Shastry B. Ananthakrishna , Ravishankar
Published: February 2020

Objective:

This study focused to systematically extract, summarize and analyse the data on
the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome.

Methods:

The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct,
CINAHL, Springer link, Web of Science from 2000-2018. English language articles and quantitative
studies focusing on leptin resistance and quality of life were included. Random effect analysis was
adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance
and quality of life which included a total of 9 studies on both RCTs and Non-RCTs.

Results:

The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance
in metabolic syndrome when compared to comparison group (-5.94(-14.28, 2.41). Two clinical
trials showed a significant effect with pooled data (5.52(2.14, 8.91). Meta-analysis of RCTs focusing on
quality of life showed significant effect on mental component (4.89 (0.16, 9.62) of quality of life (2.36
(-3.67, 8.39) when compared to comparison group.

Conclusion:

This meta-analysis suggested that lifestyle modification has a potential to improve leptin
resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined
studies are required to come to a stronger conclusion.
Trace of Long Non-Coding RNAs in Signaling Pathways in Thyroid Cancer
Authors: Safaei Mohsen , Mehri-Ghahfarrokhi Ameneh , Shojaeian Ali
Published: February 2020

Background:

Long non-coding ribonucleic acid (lncRNA) are known as similar transcripts
of messenger RNA (mRNA) whose size discrepancy is between 100 and 200 nucleotides.
Recent studies in this area have revealed that lncRNAs are involved in cancer tumorigenesis and
progression. Such molecules are transcribed from genome regions that lack open reading frame
(ORF) and fail to encode any protein. LncRNAs are characterized by tumorigenic behaviors,
which can be considered as new biomarkers. Among all types of thyroid cancer (TC), papillary
thyroid carcinoma (PTC) is the most common one.

Methods:

This review was prepared via searching of the databases of Science Direct, Directory of
Open Access Journals (DOAJ), Google Scholar, Pub-Med (NLM), Scopus, Web of Science, and
hand searching using relative keywords. The selected papers were fully reviewed and the required
information for the review was extracted and summarized.

Results:

Previous studies indicated that BRAF-activated non-protein coding RNA (BANCR) expression
had been increased in thyroid tumors compared with adjacent normal tissues.
Additionally, BANCR had mediated epithelial-mesenchymal transition (EMT) through regulating
the expression of epithelial (E)-cadherin, vimentin, and neuronal (N)-cadherin. Moreover, H19
was an example of a lncRNA that could function either as a tumor promoter or suppressor. An
important part of this study was dedicated to reviewing signaling pathways involved in TC including
extracellular-signal-regulated kinase (ERK) pathway and mitogen-activated protein kinase
(ERK/MAPK), transforming growth factor-β/ (TGF-ß)/Smads, the Janus kinase/signal transducers
and activators of transcription (JAK/STAT), P53, as well as other pathways.

Conclusion:

Briefly, this study provided an overview of the current understanding of the function
of lncRNA and micro RNAs (miRNAs) along with their interactions in TC.
The Application of Nanomaterials in Angiogenesis
Authors: Li Tianle , Zhang Tao
Published: February 2020

Induction of angiogenesis has enormous potential in the treatment of ischemic diseases and
the promotion of bulk tissue regeneration. However, the poor activity of angiogenic cells and proangiogenic
factors after transplantation is the main problem that imposes its wide applications. Recent
studies have found that the development of nanomaterials has solved this problem to some extent.
Nanomaterials can be mainly classified into inorganic nanomaterials represented by metals, metal oxides
and metal hydroxides, and organic nanomaterials including DNA tetrahedrons, graphene, graphene
oxide, and carbon nanotubes. These nanomaterials can induce the release of angiogenic factors
either directly or indirectly, thereby initiating a series of signaling pathways to induce angiogenesis.
Moreover, appropriate surface modifications of nanomaterial facilitate a variety of functions, such as
enhancing its biocompatibility and biostability. In clinical applications, nanomaterials can promote the
proliferation and differentiation of endothelial cells or mesenchymal stem cells, thereby promoting the
migration of hemangioblast cells to form new blood vessels. This review outlines the role of nanomaterials
in angiogenesis and is intended to provide new insights into the clinical treatment of systemic
and ischemic diseases.
Apoptotic Effects of Melittin on 4T1 Breast Cancer Cell Line is associated with Up Regulation of Mfn1 and Drp1 mRNA Expression
Authors: Moghaddam Farnaz D. , Mortazavi Pejman , Hamedi Somayeh , Nabiuni Mohammad , Roodbari Nasim H.
Published: February 2020

Background and Purpose:

Melittin, as the main ingredient of honeybee venom, that has shown anticancer
properties. The present study aimed at investigating the cytotoxic impacts of melittin on 4T1 breast cancer
cells.

Methods:

Hemolytic activity of different concentrations (0.125, 0.25, 0.5, 1, 2, 4, 8μg/ml) of melittin was assayed
and then cytotoxicity of selected concentrations of melittin (2, 4, 8, 16, 32, and 64μg/ml), 2 and 4μg/ml of
cisplatin and 0.513, 0.295 and 0.123μg/ml of doxorubicin was evaluated on 4T1 cells using MTT assay. We
used Morphological evaluation and flow cytometric analysis was used. Real time PCR was also used to determine
mRNA expression of Mfn1 and Drp1 genes.

Results:

All compounds showed anti-proliferative effects on the tumor cell line with different potencies. Melittin
had higher cytotoxicity against 4T1 breast cancer cells (IC50= 32μg/ml-72h) and higher hemolytic activity
(HD50= 1μg/ml), as compared to cisplatin and doxorubicin. Mellitin at 16 and 32μg/ml showed apoptotic effects
on 4T1 cells according to the flow cytometric analysis. The Real time PCR analysis of Drp1 and Mfn1 expression
in cells treated with 16μg/ml of melittin revealed an up-regulation in Drp1 and Mfn1 genes mRNA expression
in comparison with control group. Treatment with 32μg/ml of melittin was also associated with a rise in
mRNA expression of Drp1 and Mfn1 as compared to the control group.

Conclusion:

The results of this study showed that melittin has anticancer effects on 4T1 cell lines in a dose and
time dependent manner and can be a good candidate for further research on breast cancer treatment.
Etika bisnis dan undang-undang anti monopoli: penangkal bisnis curang
Authors: Widihastuti Setiati
Published: February 2020

The reality of business opportunity in New Order (ORBA) era gives only for certain businessman. The growth of private sector of during that period, in one hand be marked with biased policies lead to market distortion. In another hand, private sector of business was implication of the most of business practices unfairly. The phenomenon has been grown and  supported by the connection, directly as well as indirectly, of between policy maker and businessman. this fact pushed the release of the prohibition of monopoly and unfair business practice namely UU No. 5 /1999. Relying upon merely this law to be effective in shopping monopoly, oligopoly as well as monopsony is unreal hope. Because of those practices was common among the businessman moral "guardian" such as business ethic and good purpose as complement efforts can  be complemented as alternative solution.
Patients’ Experiences of Telehealth in Palliative Home Care: Scoping Review
Authors: Steindal Simen A , Nes Andréa Aparecida Goncalves , Godskesen Tove E , Dihle Alfhild , Lind Susanne , Winger Anette , Klarare Anna
Published: February 2020

Background

Telehealth is increasingly being used in home care and could be one measure to support the needs of home-based patients receiving palliative care. However, no previous scoping review has mapped existing studies on the use of telehealth for patients in palliative home care.

Objective

The aim of this study was to map and assess published studies on the use of telehealth for patients in palliative home care.

Methods

A scoping review was conducted using the methodological framework of Arksey and O’Malley. Reporting was guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. A systematic and comprehensive search of Medical Literature Analysis and Retrieval System Online, EMBASE, PsycINFO, and Cumulative Index to Nursing and Allied Health was performed for studies published between January 2000 and October 2018. Two authors independently assessed eligibility and extracted data.

Results

The review included 22 papers from 19 studies. Four thematic groupings were identified among the included papers: easy and effortless use of telehealth regardless of the current health condition, visual features that enhance communication and care via telehealth, symptom management and self-management promotion by telehealth, and perceptions of improved palliative care at home.

Conclusions

The use of telehealth in palliative home care seems to be feasible, improving access to health care professionals at home and enhancing feelings of security and safety. The visual features of telehealth seem to allow a genuine relationship with health care professionals. However, there are contradicting results on whether the use of telehealth improves burdensome symptoms and quality of life. Future research should investigate the experiences of using telehealth among patients with life-limiting illness other than cancer and patients aged 85 years or older. More research is needed to increase the body of knowledge regarding the effectiveness of telehealth on symptoms and quality of life.
Symptom Distribution Regularity of Insomnia: Network and Spectral Clustering Analysis
Authors: Hu Fang , Li Liuhuan , Huang Xiaoyu , Yan Xingyu , Huang Panpan
Published: February 2020

Background

Recent research in machine-learning techniques has led to signiﬁcant progress in various research ﬁelds. In particular, knowledge discovery using this method has become a hot topic in traditional Chinese medicine. As the key clinical manifestations of patients, symptoms play a signiﬁcant role in clinical diagnosis and treatment, which evidently have their underlying traditional Chinese medicine mechanisms.

Objective

We aimed to explore the core symptoms and potential regularity of symptoms for diagnosing insomnia to reveal the key symptoms, hidden relationships underlying the symptoms, and their corresponding syndromes.

Methods

An insomnia dataset with 807 samples was extracted from real-world electronic medical records. After cleaning and selecting the theme data referring to the syndromes and symptoms, the symptom network analysis model was constructed using complex network theory. We used four evaluation metrics of node centrality to discover the core symptom nodes from multiple aspects. To explore the hidden relationships among symptoms, we trained each symptom node in the network to obtain the symptom embedding representation using the Skip-Gram model and node embedding theory. After acquiring the symptom vocabulary in a digital vector format, we calculated the similarities between any two symptom embeddings, and clustered these symptom embeddings into five communities using the spectral clustering algorithm.

Results

The top five core symptoms of insomnia diagnosis, including difficulty falling asleep, easy to wake up at night, dysphoria and irascibility, forgetful, and spiritlessness and weakness, were identified using evaluation metrics of node centrality. The symptom embeddings with hidden relationships were constructed, which can be considered as the basic dataset for future insomnia research. The symptom network was divided into five communities, and these symptoms were accurately categorized into their corresponding syndromes.

Conclusions

These results highlight that network and clustering analyses can objectively and effectively find the key symptoms and relationships among symptoms. Identification of the symptom distribution and symptom clusters of insomnia further provide valuable guidance for clinical diagnosis and treatment.
Examining Patterns of Information Exchange and Social Support in a Web-Based Health Community: Exponential Random Graph Models (Preprint)
Authors: Liu Xuan , Jiang Shan , Sun Min , Chi Xiaotong
Published: February 2020

BACKGROUND

Although an increasing number of studies have attempted to understand how people interact with others in web-based health communities, studies focusing on understanding individuals’ patterns of information exchange and social support in web-based health communities are still limited. In this paper, we discuss how patients’ social interactions develop into social networks based on a network exchange framework and empirically validate the framework in web-based health care community contexts.

OBJECTIVE

This study aims to explore various patterns of information exchange and social support in web-based health care communities and identify factors that affect such patterns.

METHODS

Using social network analysis and text mining techniques, we empirically validated a network exchange framework on a 10-year data set collected from a popular web-based health community. A reply network was extracted from the data set, and exponential random graph models were used to discover patterns of information exchange and social support from the network.

RESULTS

Results showed that reciprocated information exchange was common in web-based health communities. The homophily effect existed in general conversations but was weakened when exchanging knowledge. New members in web-based health communities tended to receive more support. Furthermore, polarized sentiment increases the chances of receiving replies, and optimistic users play an important role in providing social support to the entire community.

CONCLUSIONS

This study complements the literature on network exchange theories and contributes to a better understanding of social exchange patterns in the web-based health care context. Practically, this study can help web-based patients obtain information and social support more effectively.
Оцінка ефективності спинномозкової анестезії при операціях на нижніх кінцівках хворих працездатного віку
Authors: Korobko E.Yu. , Geogiyants M.A. , Kryvobok V.I.
Published: February 2020

Актуальність. Останнім часом питанням періопераційного знеболювання при травмах нижніх кінцівок приділяється багато уваги. Остаточно не встановлено найбільш ефективного та безпечного методу анестезії при цих операціях. Більшість науковців та практикуючих лікарів вважає, що провідникові та нейроаксіальні методи анестезії найбільш відповідають цим вимогам, однак для остаточного рішення цього питання потребуються додаткові дослідження. Мета: дослідити клінічну ефективність методик спинномозкової анестезії та при її поєднанні із седацією при оперативних втручаннях на нижніх кінцівках у травматології за даними показників адекватності анестезії, інтенсивності болю та вивчення тривожності пацієнтів. Матеріали та методи. У дослідження були включені 35 хворих віком від 18 до 59 років, яким проводились операції металоостеосинтезу на нижніх кінцівках. Хворі були розподілені на групи: І (n = 17) — хворі, які прооперовані в умовах спинномозкової анестезії, ІІ — пацієнти (n = 18), які прооперовані в умовах спинномозкової анестезії з подальшою седацією 1% пропофолом. Хворі обох груп не відрізнялися за віком та антропометричними даними. Інтенсивність болю оцінювали за візуально-аналоговою шкалою (ВАШ) до та на 1-шу добу після операції, рівень особистісної та ситуативної тривожності за Спілбергером — Ханіним визначали також на цих етапах. Критерій Спірмена використовувався для виявлення взаємозв’язків між ВАШ та тривожністю. Результати. Установлено, що при поєднанні спинномозкової анестезії з внутрішньовенною седацією пропофолом у хворих зменшується інтенсивність больового синдрому після операції. У пацієнтів обох груп до операції був виявлений кореляційний зв’язок між показником ВАШ та ситуаційною тривожністю (r = 0,50; p < 0,05). У пацієнтів з ізольованою спинномозковою анестезією був виявлений взаємозв’язок між ВАШ після операції та ситуативною тривожністю до операції, що становив r = 0,51; p < 0,05; кореляційний зв’язок між ВАШ після операції та ситуативною тривожністю після операції — r = 0,53; p < 0,05. У хворих при проведенні спинномозкової анестезії з додатковою седацією кореляції між ВАШ після операції та особистісною і ситуативною тривожністю не виявлено. Висновки. Виконане дослідження дало можливість рекомендувати спинномозкову анестезію в поєднанні з внутрішньовенною седацією як метод вибору при травмах нижніх кінцівок, особливо в пацієнтів із підвищеною тривожністю.
Біль і депресія: нові можливості фармакотерапії хронічних психогенних больових синдромів
Authors: Burchinsky S.G.
Published: February 2020

У статті розглянуті сучасні погляди на проблему хронічного психогенного болю і його взаємозв’язку з депресивними розладами. З цього погляду проаналізовані вимоги до вибору оптимального фармакологічного інструменту в рамках комплексної терапії психогенного болю й депресії. Особливу увагу приділено механізмам дії та особливостям клінічного застосування дулоксетину (Дюлок) — антидепресанта з унікальними механізмами дії і клініко-фармакологічними властивостями, що дозволяють реалізувати стратегію патогенетично обгрунтованої фармакотерапії при депресії і хронічних психогенних больових синдромах. Детально розглянуті клінічна ефективність дулоксетину (Дюлок), його характеристики безпеки й рекомендації щодо практичного застосування препарату.
Закон Украины «О первичной медицинской помощи на основе семейной медицины»
Authors: . No authors
Published: February 2020

No abstract
Pengendalian Persediaan Obat dengan Minimum-Maximum Stock Level di Instalasi Farmasi RSUP Dr. Sardjito Yogyakarta
Authors: Indarti Titik Rahayu , Satibi Satibi , Yuniarti Endang
Published: February 2020

Inappropriate inventory control of medicines in hospital can lead to shortage or over stock, which is a problem faced by Dr. Sardjito Hospital Yogyakarta. The aim of this study was to examine the effect of the Minimum-Maximum Stock Level (MMSL) method on efficiency and effectivity of medicine inventory at Hospital Pharmacy Dr. Sardjito. A quasi experimental nonequivalent without control group design was applied, and purposive sampling was taken from retrospective data in January-June 2018 and the application of methods prospectively i.e. August-December 2018. Thirty-five types of medicines which met the inclusion and exclusion criteria were obtained, i.e. high cost, high volume, clinicaly important, and supply focus. These types of medicines were included in category A of ABC Pareto Analysis. The effect of minimum-maximum stock level method on inventory value, stock out value, and Inventory Turn Over Ratio (ITOR) was analysed using Wilcoxon Signed Rank Test statistic. The effect of minimum-maximum stock level method on stock out incident was analysed using Mc Nemar Test statistic. This study found that minimum-maximum stock level method to impact the positively their efficiency of drug control marked by decreased of inventory value and ITOR ideal value. The effectiveness of drug control marked by decreased incidence of stock out in Hospital Pharmacy Departement Dr. Sardjito.
Leisure Patterns and Values in Adolescents from Serbia born in 1990s: An Attempt at Building a Bridge between the Two Domains
Authors: Stepanović Ilić Ivana , Videnović Marina , Petrović Nebojša
Published: February 2020

This work is an attempt at empirically establishing a relation between leisure and values in adolescents. Being new, this topic could help a broader understanding of youth leisure and its association with inner psychological dispositions, but also with specific social context (prolonged economic crisis and post-war environment). Five typical leisure patterns were previously identified: academic, sports, going out, following celebrities in the media and music, and computers pattern. The main objective was to discover whether students with high and low scores on these patterns differ regarding their values. The sample consisted of 2426 Serbian secondary school students from 9 towns. A discriminant analysis was performed and showed that it was possible to identify a specific mix of personal and social values for every leisure pattern. This confirms the existence of a relation between students’ behaviour during free time and their values, expressed as a preference for specific personal and social goals. The resultss imply that connecting two domains is achievable and fruitful in both ways. The identified leisure patterns contribute to a more detailed and elaborate portrayal of adolescents’ values but those values also bring a new insight into specific features of adolescents’ behaviour during leisure time.
Kosovo and Metohija or the European Union ‒ a rhetorical dilemma in the Serbian political discourse
Authors: Marković Ksenija , Jovanović Marko , Matijević Branka
Published: February 2020

As the loss of Kosovo has been de facto re-inflicted in recent years, the question should be raised as to how great an influence the Kosovo myth wields today. It is particularly interesting to consider the issue in the context of European integration and the fact that recognition of Kosovo and Metohija’s self-proclaimed independence is usually stated as an essential condition and a key obstacle to Serbia’s accession to the EU. It is an undisputable fact that Kosovo and Metohija and the Kosovo myth are a part of culture, history, religion, and folklore of Serbian people, and it is without doubt difficult to renounce all that, even if personal and collective prosperity is offered in lieu of it, which is deemed by a certain portion of the Serbian public to come as a result of the accession to the EU. The aim of this paper is to establish which portion of public opinion is willing to make such a sacrifice in relation to the current attempts at resolution of the Kosovo question. It is the authors’ ambition to answer the following question: To what extent does the position on the status of Kosovo and Metohija influence the public opinion on Serbia’s membership in the European Union? With an intention of answering the research question the authors rely on the data acquired through empirical-quantitative study The Notions of the EU and Russia in the Serbian Public 2018, Institute of Social Sciences Belgrade, where a structured on-line questionnaire was used as a means of data collection. The study results clearly indicate the popular support for Serbia’s accession to the EU while at the same time the method of resolution of the Kosovo question deeply impacts the public opinion on Serbia’s membership in the EU. A conclusion can be drawn that, if the public is presented with the choice between Kosovo and the EU, the certainty of citizens opting for the EU will rapidly decline.
MODIFIED PYRAGAS METHOD FOR MULTIPLE SPATIAL LIMIT SETS AND CHAOS CONTROL IN MIMO CASCADE NONLINEAR SYSTEMS
Authors: Samardžić Biljana , Zlatković Bojana
Published: February 2020

The modified Pyragas method for the multiple spatial limit sets and chaos control in MIMO cascade nonlinear systems is presented in this paper. Also, oscillatory and chaotic dynamic analysis of concrete MIMO3 cascade nonlinear system is performed before and after the application of control. Bifurcation diagrams and spatial phase portraits of uncontrolled and controlled MIMO3 system are used for the purposes of analysis.
INFLUENCE OF CERTAIN MOTOR ABILITIES ON BALL THROWING VELOCITY IN GOALBALL: A PILOT STUDY
Authors: Jorgić Bojan , Grbović Aleksandra , Đorđević Stefan , Stanković Veroljub , Stanković Ratko
Published: February 2020

The aim of the research was to determine the influence of sprint performance and explosive strength on ball throwing velocity in Goalball. The sample of participants consisted of 12 nationally and internationally ranked Goalball players, with an average age of (25.17±8.03). To evaluate sprint performance, the 5 and 10 meter sprint tests were used. To evaluate explosive strength, the standing long jump and seated medicine ball throw were used. The results of the regression analysis have indicated that the entire system of applied variables is statistically significantly connected and influences ball throwing velocity. At the same time, we evaluated the statistically significant influence of the seated medicine ball throw variable. We can conclude that as part of the fitness training of Goalball players, it is necessary to work on improving sprint performance and explosive strength due to the ability of rapid transition of the players from the defensive phase to the attack phase. It is especially important to develop upper-body explosive strength in order to increase ball throwing velocity and create the possibility for greater effectiveness of Goalball players.
Investigations into the Sequential Application of Crease Resist Finish, Tannin and Cationic Reactant to Improve the Resistance of Sulphur Dyes to Oxidation
Authors: Mohtashim Quratulain , Rigout Muriel
Published: February 2020

The importance of sulphur dyes are realized due to the fact that they offer an economical method of achieving dyeing of good color strength and acceptable fastness on cellulosic substrates. However, the main limitations associated with this class of dye are the lack of availability of bright colors and it’s fading on exposure to laundering with detergent and perborates/peroxides formulations. In order to meet the growing requirements of customers regarding the higher wash fastness, garment traders are in turn demanding their suppliers to achieve these properties against single and multiple washes. In this study, sulphur black 1 dyed cotton fabric has been aftertreated with Fixapret CP, Bayprotect Cl and CC (Choline Chloride) with various sequential combinations to improve the wash fastnesss of the dyed fabric against the aggressive ISO-1O5 CO9 washing system. Sequential application of Bayprotect Cl followed by CC was found to offer a significant improvement causing a 12% reduction in percentage colour loss relating to the untreated fabric, which was comparable to the independent application of Fixapret CP with minimum deleterious effects on the hue, chroma and tensile strength of the fabric.
Review of Electrical Motor Drives for Electric Vehicle Applications
Authors: Cao Wenping , Bukhari Abid Ali Shah , Aarniovuori Lassi
Published: February 2020

EVs (Electric Vehicles) have been rejuvenated over the last decades while the motor drive technologies are still evolving. This paper provides a review of electrical motor drive technologies used in EV applications, with a performance comparison of candidate machines and their drive topologies. EV applications demand high efficiency, high torque density, high reliability, and wide speed range while reducing weight, complexity, total costs and environmental impact. In the literature, DC (Direct Current) motors, IMs (Induction Motors) and PM (Permanent Magnet) motors can be generally found in marketplace whilst RMs (Reluctance Motors) have been researched for some time and are nearing commercial availability. This paper evaluates the performance of these four main types of electrical motor drives for EV propulsion applications using analytical methods. PM motors may offer the best performance in terms of torque density and compactness but the cost is the highest (primarily dominated by rare-earth permanent magnets), limiting their widespread application in mass production EVs. DC motors have their own merits but suffer from limited power density and necessity for maintenance. Induction motor drives are a mature and proven technology. In particular, squirrel-cage IMs are robust, reliable and inexpensive, striking a balance between system cost and complexity, power density and extended speed range. Reluctance motors can provide a good torque density and cost effective EV drive solutions. Their drawbacks can also be overcome by the use of power electronic converters and advanced control strategies. Induction and reluctance motor drives are well suited for cost sensitive mass production EV applications. Looking to the future, increased hybridization may be a way forward in industry which combines attractive features of different electrical machines and control algorithms and still offer much promise in performance and total cost. At last, reliability study on EVs requires historical information and driving patterns, demanding research expertise in eco-sociology, human behaviors as well as human-machine interface.
Economically Effective and Intelligently Responsive Home Energy Management System
Authors: Irfan Mushtaq Muhammad , Siddiq Asif , Owais Tariq Muhammad , Ali Akbar , Zahra Anum
Published: February 2020

Energy management in home is one of the major issue now-a-days. There are different types of load like shiftable, non-shiftable, seasonal loads and auxiliary loads. In this research article, an energy management system is proposed for home which helps to schedule different loads on the basis of their types and price. It will help to minimize the cost of electricity by shifting load from peak time to off peak time. Emission will be minimized by charging penalty by adopting multi-objective optimization. Each source of energy has its own price of penalty with respect to time. Penalty is charged to minimize the use of sources like commercial supply and diesel generators which emits hazardous gases. In proposed model, user will get electricity from commercial supply, diesel generators and solar panels to provide continuous supply of electricity to fulfill the energy demand. The shiftable loads will be shifted from peak time to off peak time and higher price source to lower price source to minimize the overall price. In this research, we have proposed an EEIR (Economically Effective and Intelligently Responsive) HEMS (Home Energy Management System) by solving multi-objective optimization problem from BILP (Binary Integer Linear Programming) using branch and bound algorithm.
Routine of Encryption in Cognitive Radio Network
Authors: Raza Asif , Tanveer Meeran Muhammad , din Muizzud
Published: February 2020

Today data transmission is very important through different channels. Need of network security comes to secure data transformation from one network to another network. As the complexity of the systems and the networks increases, weakness expands and the task of securing the networks is becomes more convoluted. Duty of securing is done by Cryptography techniques. A colossal amount of data is exchanged over public networks like the internet due to immense accommodation. This includes personal details and confidential information. It is important to prevent the data from falling into the wrong hands. So, due to this factor we use cryptography. Encryption and decryption are the basic terms that are used in cryptography. There are few algorithms which used including, AES (Advanced Encryption Standard), DES (Data Encryption Standard), 3DES (Triple Data Encryption Standard) and BLOWFISH. The main contribution of this paper is to provide an algorithm that is useful for data transformation in cognitive radio networks. In this research, we have drawn a new symmetric key technique that is for the usage of cryptography which is helpful to make the data saved from others.
Role of Situational Agile Distributed Model to Support Modern Software Development Teams
Authors: Hashmi Amber Sarwar , Hafeez Yaser , Jamal Muhammad , Ali Sadia , Iqbal Naila
Published: February 2020

ADSD (Agile Distributed Software Development) is a growing trend for software development organizations to develop quality software with limited cost and time. However, it gives rise to additional situational challenges. Situational variations result in unstable agile architecture which gets highly affected. Although the present literature focuses on agile architecture but effect of situational variation on the agile architecture still needs consideration. One possible solution is development of conceptual model and incorporation of multiple situational factors. This research study aims to identify the most relevant situations and propose situational ADSD approach for the development of situation-based software architecture framework for agile distributed projects. The study focuses on agile methods, rendering identified situational variations. The approach is developed through analyzing data from literature and their associated work documents. Comprehensive survey helps to bridge the gaps from conceptual to architecture model. The experimental results are acquired through both practical and statistical analysis. The results support Conway’s law, e.g. correlation that maps architecture with the communication and coordination needs. Correlation results show that architecture has major contribution in ADSD and validate the relationship among conceptual model and architecture model. The results also suggest that stable architecture in ADSD can positively affect the product.
Methane Production by Anaerobic Digestion of Spent Wash in Continuous Stirred Tank Reactor
Authors: Panhwar Sallahuddin , Sahito Abdul Razaque , Solangi Ghulam Shabir , Mahar Rasool Bux Mahar , Lal Jawahar
Published: February 2020

DSW (Distillery Spent Wash) is superfluous residual liquid waste produced during the process of alcohol production. It is one of the most critical environmental issues which cause pollution. Despite strictness of standards imposed on effluent quality, partially or untreated effluent very often finds access to surface and groundwater. The distillery wastewater becomes a serious risk to the water quality in several regions around the globe. The ever-increasing generation of DSW lead to take an attempt to investigate a few aspects of anaerobic digestion of spent wash collected from a distillery. In the present study CSTR (Continuous Stirred Tank Reactor) was used at laboratory scale. The study was carried out to evaluate the performance of CSTR after the effective startup and the gradual increment in the OLR (Organic Loading Rate). The maximum methane gas (CH4) of 71.68 ml at the OLR of 1.0g of COD (Chemical Oxygen Demand)/L was observed. The optimum COD removal efficiency of the CSTR was 91% corresponding to OLR of 1g of COD/L. The pH ranges from 7.1-7.3 gave better performance and maximum stability of the process. By increasing the ORL, the VFA (Volatile Fatty Acids) content was also increased and reached to the 1.5g COD/L. However, the removal efficiency of TS (Total Solids) increased at an accelerated rate of OLR.
First cobalt complexes with methyl pyruvate semi/thiosemicarbazone - synthesis, physico-chemical and structural characterization
Authors: Rodic Marko , Miskov-Pajic Vukoslava , Leovac Vukadin , Radanovic Mirjana , Vojinovic-Jesic Ljiljana , Belosevic Svetlana , Jacimovic Zeljko , Zivkovic-Radovanovic Vukosava
Published: February 2020

In the reaction of acetone solutions of CoX2?nH2O (X = Cl, Br) with methyl pyruvate semi/thiosemicarbazone (Hmps, Hmpt) the first Co(II) complexes with these ligands, i.e., [Co(Hmps)(H2O)X2] (X = Cl (1), Br (2)), [Co(Hmpt)2][CoCl4]?2H2? (3) and [Co(Hmpt)2]Br2?Me2CO (4) were obtained. Complexes 1 and 2 represent the first examples of metal complexes of Hmps. All the obtained compounds were characterized by elemental analysis, conductometry, magnetic measurements, and IR spectra, and for complexes 2?4, single crystal X-ray diffraction analysis was also performed. The effective magnetic moments were close to the upper limit (5 ?B) for complexes 1 and 2, and close to the lower limit (4.4 ?B) for complexes 3 and 4, and as such are characteristic for high-spin Co(II) complexes. Structural analysis showed that both ligands coordinate in a neutral form in a tridentate manner, via the ester oxygen, imine nitrogen and the oxygen atom of the ureido (Hmps), or the sulfur atom of the thioureido group (Hmpt). The central metal atoms are situated in a deformed octahedral coordination environment. Complex 2 has cis-Br configuration, while complexes 3 and 4 have mer-configuration.
Development of bioactive components from Chaenomeles sinensis leaves
Authors: Zhou Ying , Zhao Weiwei , Shang Fude , Zhang Dangquan
Published: February 2020

Due to its good ornamental value, Chaenomeles sinensis has a long history of planting in China, and its fruit has health efficacy. The components from fruit and the functions of them have been fully excavated and developed, but there is little research on Chaenomeles sinensis leaves. In our study, the components of Chaenomeles sinensis leaves were extracted by ethanol and acetone. The extracts were identified by FT-IR and GC-MS in order to detect and excavate the bioactive components. The result shows that Chaenomeles sinensis leaves contain alcohols, ethers, aldehydes and other substances which were identified by FT-IR. The main volatile organic compounds (VOC) of Chaenomeles sinensis immature leaves are alcohols, ketones, alkenes and alkanes. Some substances can be simultaneously extracted by two solvents. Ethanol extracts contain high content of biogenic substances, and acetone solvents can effectively extract bioenergy substances.