bluuebunny/crossref_metadata_2025 huggingface dataset:
New Paradigm of Personal Health Monitoring: Nanomaterial-based In-textile Sensors
Authors: Smith Aaron , Li Rui , Xu Lulu , Tse Zion
Published: December 2022

The use of nanomaterial-based in-textile sensors for personal health monitoring has recently emerged as a new paradigm for healthcare. This approach offers several advantages over traditional monitoring methods, such as increased comfort, convenience, and accuracy. In-textile sensors are integrated into clothing or wearable devices, allowing for continuous and unobtrusive monitoring of a range of physiological parameters, such as heart rate, body temperature, and blood pressure. Nanomaterials such as graphene and carbon nanotubes enable the sensors to be highly sensitive and selective, allowing for the detection of even small changes in the monitored parameters. However, there are also challenges and limitations to the widespread adoption of in-textile sensors for personal health monitoring. One major challenge is the integration of the sensors into wearable devices, as the sensors must be flexible, lightweight, and durable in order to be comfortable and practical for daily use. Additionally, there are concerns about the potential toxicity of some nanomaterials, and more research is needed to assess the safety of these materials for long-term use in personal health monitoring. In this review, we provide an overview of the current state of research on in-textile sensors for personal health monitoring, including the potential benefits and challenges of this technology. This review highlights the potential of in-textile sensors for personal health monitoring, as well as the challenges and limitations of this technology. Further research is needed to address these challenges and fully realize the potential of in-textile sensors for healthcare.
Safety and effectiveness of ByCross Rotational Atherectomy and Aspiration Device: A prospective, multi-center pre-market approval study
Authors: Teßarek Jörg , Kolvenbach Ralf
Published: December 2022

PurposeTo demonstrate safety and effectiveness of the novel ByCross Atherectomy System for percutaneous treatment of TASC A-D de novo infrainguinal arterial >80% stenosis down to the tibioperoneal tract.Materials and Methods41 lesions were treated in this prospective, nonrandomized pre-market approval study across 2 German centers. Mean patient age was 72 years with 62% male. Average lesion length was 125±118 mm (30 to 450mm) with 96.4±6.2% stenosis. The primary performance endpoint was the acute procedural success defined as residual stenosis of ≤ 50% and ≤ 30% after atherectomy and adjunctive treatment. The primary safety endpoint was the major adverse event (MAE) rate through 30 days. Secondary endpoints were DUS measured target lesion restenosis and the ABPI at discharge, 30 and 180 days and any MAE through 6 months.ResultsThe acute procedural success rate was 95.12% with 11/41 (26.82%) lesions being recanalized without wire guidance. Embolic protection was not used. Adjunctive POBA or stenting was used in 40/41 (97.56%) and 12/41 (29.26%), respectively. There were no MAE’s at 30 days. DUS measured mean residual stenosis was 5.7% at discharge and 21.7% at 6 months FU. Mean ABPI was 0.8, 1.0 and 0.8 at baseline, discharge, and 6 months FU respectively.ConclusionsThe ByCross Atherectomy System has shown to be safe and effective for the atherectomy of complex lower-extremity arterial lesions even without guidewire. Trial registration October 17, 2018 ,retrospectively registered. ClinicalTrials.gov Identifier: NCT03724279; https://clinicaltrials.gov/ct2/show/record/NCT03724279
Characterizing the tropical cyclone Seroja using the Indonesian CORS network
Authors: Putri Nabila S.E. , Wijaya Dudy D. , Abdillah Muhammad R. , Tanuwijaya Zamzam A.J. , Wibowo Sidik T. , Kuntjoro Wedyanto
Published: December 2022

In the early April 2021, the tropical cyclone Seroja was formed over the Savu Sea in the southeastern Indonesia. In this study, we utilized the Global Navigation Satellite Systems (GNSS) observations to derive precipitable water vapor (PWV) from several permanent stations in the region to study Seroja. From in situ meteorological observations, we found that surface pressure values dropped by more than 20 hPa during Seroja, relative humidity increased, and temperature was reduced. PWV at two nearest stations showed an upward trend (around 70 mm at its peak) during the formation of the cyclone, then dropped immediately (less than 20 mm). After Seroja, the mean PWV was lower (56 mm before and 39 mm after), whereas the standard deviation was higher (5-6 mm before and 9 mm after). We also compared hourly PWV with precipitation from GSMaP. Before Seroja, some precipitation events occurred, followed by heavy rains that lasted for several days when the cyclone was passing. After Seroja had passed, both PWV and precipitation dropped significantly. However, while PWV values after Seroja was fluctuating, no rain occurred. We then investigated the water vapor budget to understand the change of PWV over time. We found that precipitation and the divergence of moisture flux played an important role in the change of PWV over time. Heavy precipitation during Seroja resulted in a drop in PWV, although the negative divergence provided a bit of offset. After Seroja had passed, no precipitation occurred and the change of PWV could be attributed mainly to the moisture divergence. The lagged correlation between PWV and precipitation was determined using moving average over the timeseries. The highest correlation was found 1-2 days before the event with moving average periods of 7 and 10 days.
Ultra-scaled Phototransistors based on Monolayer MoS2
Authors: Schranghamer Thomas , Das Saptarshi
Published: December 2022

For decades, the fundamental diffraction limit of light has stymied the dimension scaling for optoelectronic devices, which remain largely stuck at the micrometer scale or larger. However, recent studies have shown that nanoantennas and plasmonic devices capable of capturing/directing electromagnetic waves are one avenue of artificially focusing incident light into sub-wavelength active areas, thus enabling applications such as photodetection and communication in defiance of the diffraction limit. Despite these advancements, the ultimate scaling limits of photodetector active areas have remained largely untested. In this work, we present a two-dimensional (2D) monolayer molybdenum disulfide (MoS2) photodetector that is able to reach responsivities and detectivities in excess of 108 A/W and 1012 Jones, respectively, and display a high dynamic range while possessing an active area of only 0.0065 μm2. Together, the nano-scale active area and ultra-thin-body nature of the sensing material correspond to an active volume of ~4.23 × 10-6 μm3, approximately 3× smaller than the current smallest photodetector reported in the literature. These results indicate that continued scaling of photodetectors beyond the diffraction limit has enormous potential so long as methods of focusing incident light continued to be developed concurrently.
Phase angle is related to physical function and quality of life in preoperative patients with lumbar spinal stenosis
Authors: Otsubo Ryota , Hashida Ryuki , Murotani Kenta , Iwanaga Sohei , Hirota Keisuke , Koya Syunji , Tsukada Yuya , Ogata Yuta , Yokosuka Kimiaki , Yoshida Tatsuhiro , Nakae Ichiro , Fudo Takuma , Morito Shinji , Shimazaki Takahiro , Yamada Kei , Sato Kimiaki , Matsuse Hiroo , Shiba Naoto , Hiraoka Koji
Published: December 2022

Lumbar spinal stenosis (LSS) can interfere with daily life and quality of life (QOL). Evaluating physical function and QOL and helping them to improve is the focus of rehabilitation. Phase angle (PhA) assessment is widely used to measure body composition and is considered an indicator of physical function and QOL. This study investigated the relationship between PhA and physical function, physical activity, and QOL in patients with LSS. PhA, handgrip strength, walking speed, Timed Up and Go test (TUG), Life Space Assessment (LSA), Prognostic Nutritional Index (PNI), Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ), and EQ-5D were assessed and statistically analyzed. The study included 104 patients with LSS. Multiple regression analysis of PhA adjusted for age, sex, and body mass index (Model 1) and for Model 1 + PNI (Model 2) showed significant correlations (P < 0.05) with handgrip strength, walking speed, TUG, and LSA. Regarding QOL, PhA showed a significant correlation (P < 0.05) with lumbar function in JOABPEQ and a significant trend (P < 0.1) in EQ-5D in both models. PhA was associated with physical function and QOL in patients with LSS and may be a new clinical indicator in this population.
Effects of Exogenous Glycine Betaine and Cycloleucine on Photosynthetic Capacity, Amino Acid Composition, and Hormone Metabolism in Solanum melongena L
Authors: Niu Tianhang , Zhang Jing , Li Jing , Gao Xiaoping , Ma Hongyan , Gao Yanqiang , Chang Youlin , Xie Jianming
Published: December 2022

Although exogenous glycine betaine and cycloleucine have been reported to affect animal cell metabolism, their effects on plant growth and development have not been studied extensively. Different concentrations of exogenous glycine betaine (20, 40, and 60 mmol L− 1) and cycloleucine (10, 20, and 40 mmol L− 1), with 0 mmol L− 1 as control, were used to investigate the effects of foliar spraying of betaine and cycloleucine on growth, photosynthesis, chlorophyll fluorescence, Calvin cycle pathway, abaxial leaf burr morphology, endogenous hormones, and amino acid content in eggplant. We found that 40 mmol L− 1 glycine betaine had the best effect on plant growth and development; it increased the fresh and dry weight of plants, increased the density of abaxial leaf hairs, increased the net photosynthetic rate and Calvin cycle key enzyme activity of leaves, had an elevating effect on chlorophyll fluorescence parameters, increased endogenous IAA content and decreased ABA content, and increased glutamate, serine, aspartate, and phenylalanine contents. However, cycloleucine significantly inhibited plant growth; plant apical dominance disappeared, plant height and dry and fresh weights decreased significantly, the development of abaxial leaf hairs was hindered, the net photosynthetic rate and Calvin cycle key enzyme activities were inhibited, the endogenous hormones IAA and ABA content decreased, and the conversion and utilization of glutamate, arginine, threonine, and glycine were affected. Combined with the experimental results and plant growth phenotypes, 20 mmol L− 1 cycloleucine significantly inhibited plant growth. In conclusion, 40 mmol L− 1 glycine betaine and 20 mmol L− 1 cycloleucine had different regulatory effects on plant growth and development.
Duodenal metastasis of renal cell carcinoma: a case report
Authors: Yinhe Sikong , Yang Jiao , Kun Feng , Aijun Zhang
Published: December 2022

Background
Duodenal metastasis of renal cell carcinoma(RCC) is a very rare disease entity, and often occurs years after nephrectomy for RCC.
Case presentation:
Here we report a case of 53-year-old woman presenting with chronic anemia and malnutrition 4 years after right nephrectomy. On esophagogastroduodenoscopy(EGD), a giant semitransparent mass was located in the descending segment of duodenum, and the patient underwent Whipple’s operation with excellent recovery. The histopathology confirmed the diagnosis of duodenal metastasis of RCC.
Conclusion
In a patient with past history of nephrectomy for RCC, when encountered with unique endoscopic features, metastasis of RCC should be suspected and perform thorough evaluation, including surgery.
Looking for biomarkers in interferon response pathway to predict response to oncolytic HSV-1 in breast cancer: An ex vivo study
Authors: Nejatipour Zahra , Toulabi Ladan Teimouri , Forooshani Ramin Sarrami , Barough Mahdieh Shokrollahi , Farahmand Mohammad , Biglari Alireza , Azadmanesh Kayhan
Published: December 2022

Breast cancer is the most common malignancy in women worldwide. Administration of oncolytic viruses is one of the novel promising cancer therapy approaches. Replication of these viruses is usually limited to cancer cells that have interferon (IFN) signaling defects. However, Interferon signaling is not completely impaired in all cancer cells which may limit the benefits of virotherapy. Identification of realistic IFN-mediated biomarkers to identify patients who most likely respond to virotherapy would be helpful. In this study, eight patients-derived primary tumor cultures were infected with an ICP34.5 deleted oHSV, then the rate of infectivity, cell survival, and expression of the gene involved in IFN pathway were analyzed. Data showed that mRNA expressions of Myeloid differentiation primary response protein (Myd88) is significantly higher in tumors whose primary cultures showed less cell death and resistance to oHSV infectivity (P-value < 0.05). The differentiating cut off of Myd88 expression, inferred from the receiver operating characteristic (ROC) curve, predicted that only 13 out of 16 other patients could be sensitive to this oHSV. Identifying such biomarker improves our ability to select the patients who do not exhibit resistance to virotherapy.
Pilot study examining the feasibility and safety of an exercise during chemotherapy in patients with gastrointestinal cancers
Authors: Park Song Ee , Kim Du Hwan , Kim Don-Kyu , Ha Joo Young , Jang Joung-Soon , Choi Jin Hwa , Hwang In Gyu
Published: December 2022

Purpose
Sarcopenia is a poor prognostic factor in cancer patients, and exercise is one of the treatments to improve sarcopenia. However, there is currently insufficient evidence on whether exercise can improve sarcopenia in patients with advanced cancers. This study examined the feasibility of exercise in advanced gastrointestinal (GI) cancer patients treated with palliative chemotherapy.
Methods
Between 2020 and 2021, 30 patients were enrolled in a resistance and aerobic exercise program for six weeks. The exercise intervention program (EIP) consisted of low, moderate, and high intensity levels. Patients were asked to select the intensity level according to their ability. The primary endpoint was the feasibility of the EIP measured by compliance during the six weeks. A compliance of over 50% was considered acceptable. The secondary endpoints were changes in weight and muscle mass, safety, quality of life (QoL) and overall survival (OS).
Results
The median age of the study’s participants was 60 (30–77). The total compliance to the EIP was 63.3% (19/30 patients). Sixteen (53.3%) patients had a compliance of over 80%. The attrition rate was 30.0% (9/30). The mean exercise time was 41.4 minutes, and the aerobic exercise was 92.3% and the resistant exercise was 73.7%, and both exercise was 66.5%. Most patients performed the moderate intensity level exercises at home or near their home. The mean skeletal muscle index (SMI) was 43.5 cm2/m2 pre-chemotherapy and 42.2 cm2/m2 after six weeks of chemotherapy, with a decrease of -1.2 ± 2.8 cm2/m2 (-3.0%) (p = 0.030). In the poor compliance group, the mean SMI decrease was − 2.8 ± 3.0 cm2/m2 which was significantly different (p = 0.033); however, in the good compliance group, the mean SMI decrease was − 0.5 ± 2.5 cm2/m2 which was maintained over the six weeks (p = 0.337). The insomnia was showed a better score (p = 0.042) and there were no serious adverse events.
Conclusions
The EIP during palliative chemotherapy in advanced GI cancer patients showed good compliance. In the good compliance group, muscle mass and physical functions were maintained for six weeks. The EIP was safe, and the QoL was maintained. Based on this study, further research in exercise intervention in advanced cancer patients is needed.
Novel Application of Real-Time Editable 3D-reconstructed Imaging in a Mixed-Reality Holographic Overlay Using a Video Pass-through Head-Mounted Display – A Pathway to future Navigation in Thoracic Surgery?
Authors: Arensmeyer Jan , Bedetti Benedetta , Schnorr Philipp , Buermann Jens , Zalepugas Donatas , Schmidt Joachim , Feodorovici Philipp
Published: December 2022

Introduction: 3D reconstructions of widely available high-resolution imaging is only rarely used for
preprocedural assessment in thoracic surgery. However, it is a promising tool that aims to improve
patient-specific treatment planning. Increasingly available mixed reality hardware based on video
pass-through technology enables to project image data as a hologram onto the patient. We describe
the novel method of real-time 3D surgical planning in a mixed reality setting presenting two
representative cases.
Material and Methods: A mixed reality system was set-up using a highperformance
workstation running a video pass-through based head-mounted display. Image data of
computer tomography was imported and visually customized through live editing. The image-based
hologram was projected onto the patient highlighting the regions of interest.
Results: Two oncological
cases were selected, both presenting large tumor masses in the thoracic cavity. We aligned 3D
holographic image data onto the patient allowing us to investigate the relationship between
anatomical structures and their respective body position.
Discussion and Outlook: The exploration of
holographic overlay proved to be promising in improving preprocedural surgical planning, particularly
on complex oncological tasks in the thoracic surgery area. A pilot study on approach planning shall
therefore be conducted. Ongoing technological progresses of extended reality hardware and
intelligent software features will most likely enhance applicability and range of use in surgical fields
within the near future.
The Schrödinger representation of Heisenberg group in terms of linear canonical transform
Authors: Kumar Amit , Prasad Akhilesh
Published: December 2022

In this paper, we deduce the Heisenberg group by using the translation and modulation operators of the linear canonical transform(LCT) in place of the Fourier transform and corresponding Schr\"{o}dinger representation is given. Apart from this the linear canonical Wigner transform is defined. Moreover, various analytic expressions, such as Schr\"{o}dinger representation is a unitary operator on $ L^{2}(\mathbb{R}^{n}) $ are discussed.
Food and feeding habits of four major commercial fish species on the central west coast of India
Authors: khandeparkar Akshadha S. , Gauns Manguesh , Sawant Nitin S.
Published: December 2022

In the present study, four species of commercial fish species namely Rastrelligar kanarguta, Tenualosa ilisha, Mugil cephalus and Sardinella longiceps were studied to understand their planktonic gut composition. This investigation was carried out by collecting locally caught fresh fish specimens from Coco beach at Nerul, Bardez-Goa, India from October 2019 to March 2020. These specimens were caught using the fishing gears such as cast net/gill net/seine nets operated from motorized canoes/crafts in the near shoreline region. Fishes mentioned in this report feed mainly on zooplankton i.e., copepods and bivalves. The copepod that dominated the gut content most of which were in semi-digested form apart from diatom and bivalve larvae. However, during the winter period, February and March, gut content was full of non-motile, marine dinoflagellates (ca. 200–500µm in size) represented by Pyrocystic sp. The study concludes that these commercial fishes show seasonal variation in feeding patterns and food selection (zooplankton ← → phytoplankton)
Characteristics of the tropical tropopause over the northeast monsoon region
Authors: Pooja Purushotham , Mehta Sanjay Kumar , Kakkanattu Sachin Philip , Betsy K. B. , Seetha C. J. , Musaid P. P.
Published: December 2022

In this study, we have characterized the tropical tropopause parameters such as the cold point tropopause (CPT) height (CPT-H) and temperature (CPT-T), convective tropopause (COT) height (COT-H) and temperature (COT-T), and the tropical tropopause layer (TTL) using radiosonde observations during 2014–2019 over Chennai (13.0oN, 80.06oE) located in the northeast (NE) monsoon region. The water vapor and ozone data from the microwave limb sounder (MLS) simultaneous to the radiosonde observations are also utilized to understand their roles on the CPT variations for different convective conditions obtained from Infrared brightness temperature (IRBT) data. CPT over Chennai becomes higher (17.6 ± 0.3 km) and colder (189.7 ± 0.9 K) during the winter season and lower (16.6 ± 0.2 km) and warmer (192.1 ± 1.0 K) during the summer monsoon season, however, not in the same month. The water vapor (CPT-W) and ozone (CPT-O) mixing ratios at CPT are found to be lower (~ 70 ± 1.4 ppmv and 3.1 ± 0.4 ppmv) during the winter season and higher (153 ± 4.2 ppbv and 4.8 ± 0.6 ppmv) during summer monsoon season. COT, however, becomes lower (12.4 ± 0.3 km) and higher (13.3 ± 0.3 km) during premonsoon and summer monsoon seasons, respectively. The TTL thickness is lesser (3.5 ± 0.6 km) and greater (4.8 ± 0.8 km) during winter and summer monsoon seasons. Over Chennai, the seasonal variation of the upper troposphere and lower stratospheric temperature, water vapor, and ozone anomalies are found to be in phase. We have categorized tropical convections as non-penetrative and penetrative. It is observed that the TTL temperature warms with the increasing strength of the non-penetrative convections and cools for the penetrative convection.
NRF2 suppression increases the susceptibility of hepatocellular carcinoma cancer cells to paclitaxel
Authors: Maghsoudi Mohaddeseh , Khalaj-Kondori Mohammad , Safaei Sahar , Amini Mohammad , Doustvandi Mohammad Amin , Hasani Shima , Riazi Negin , Baradaran Behzad
Published: December 2022

Background
Hepatocellular carcinoma (HCC) is one of the principal causes of cancer related death globally, and is one of the most common primary liver malignancies. The nuclear factor erythroid 2–related factor 2 (NRF2), regulates a wide range of detoxifying and antioxidant protection gene expression in the liver. Increased NRF2 expression is positively associated with the progression of a variety of cancers, including hepatocellular carcinoma. Our study aimed to consider the combination effect of NRF2-specific siRNA and paclitaxel (PTX) on apoptosis, autophagy induction, growth, and migration inhibition in HCC.
Methods
At first, using bioinformatics studies, HepG-2 cells were selected for the functional experiment. Then transfection of the cells was conducted with NRF2-siRNA and then treated with PTX. Cell viability was measured by the MTT assay, apoptosis was evaluated by the Annexin V/PI staining, autophagy was detected by the MDC staining, cell cycle arrest was determined by the flow cytometry, and cell migration was assessed by the wound healing assay. Finally, qRT-PCR was used to analyze the expression of migration and apoptosis genes (MMP-9, MMP-2, Bax, caspase-3, caspase-9, and Bcl-2).
Results
According to the results of our study, the expression of NRF2 was noticeably lessened by the NRF2-siRNA. Also, the NRF2-siRNA transfection could increase PTX-induced apoptosis. Besides, NRF2-siRNA and PTX were demonstrated to cooperatively suppress cell migration, increase arrest in sub-G1 and G2/M phase, and induce autophagy in HepG-2 cells. Additionally, we found that the use of NRF2-siRNA increased the sensitivity of HepG-2 cells to PTX via modulating the expression of apoptosis-related genes, including Bax, caspase-3, caspase-9, and Bcl-2 and migration-related genes including MMP-2 and MMP-9.
Conclusion
NRF2 knockdown in combination with PTX could be a promising treatment for hepatocellular carcinoma.
Runs of homozygosity and signatures of selection for number of oocytes and embryos in the Gir Indicine cattle
Authors: Rocha Renata de Fátima Bretanha , Garcia Arielly Oliveira , Otto Pamela Itajara , Silva Marcos Vinícius , Martins Marta Fonseca , Machado Marco Antônio , Panetto João Claudio , Guimarães Simone Eliza Facioni
Published: December 2022

Runs of homozygosity (ROH) and signatures of selection are results of selection processes in livestock species that has been shown to affect several traits in cattle. The aim of the current work was to verify the profile of ROH and inbreeding depression in the number of total (TO) and viable oocytes (VO), and number of embryos (EMBR) in Gir Indicine cattle. In addition, we aimed to identify signatures of selection, genes and enriched regions between Gir subpopulations sorted by breeding value for these traits. The genotype file contained 2,093 animals and 420,718 SNP markers. Breeding values used to sort Gir animals were previously obtained. ROH and signature of selection analyses were performed using PLINK software, followed by ROH- and pedigree-based inbreeding (FROH) and search for genes and their functions. A total of 105,327 ROHs were found in Gir cattle. ROHs were separated in classes according to the size, ranging from 1 to 2 Mb (ROH1–2 Mb: 58.17%), representing ancient inbreeding, ROH2–4 Mb (22.74%), ROH4 − 8 Mb (11.34%), ROH8 − 16 Mb (5.51%) and ROH> 16 Mb (2.24%). Putting together our results, we conclude that the increase in general ROH-based and pedigree-based inbreeding significantly decreases TO and VO; however, the way ROH affects the traits vary among chromosomes. In the analysis for signatures of selection, we identified 15 genes from 47 significant genomic regions, indicating differences in populations with high and low breeding value for the three traits.
Some Thermodynamics Aspects in Regular Gaussian Black Hole
Authors: malekolkalami Behrooz , Sharafi Maasoomeh
Published: December 2022

Asymptotically Anti–de Sitter (Black Hole) spacetimes are of theoretical and mathematical interest and attractive. Especially if these spaces are free of singularity, attraction to them may increase. An example of such spacetime is the Regular Gaussian Black Hole. In this manuscript, apart from examining some properties of these black holes, the comparison between the de Sitter and Anti–de Sitter types shows that the latter has a much better match with the laws of the real world and especially with the laws of thermodynamics.
Three-dimensional relationship between the degree of bilateral impacted mandibular third molars angulation and the mandibular dental arch parameters: a cross-sectional comparative study
Authors: Haider Ohood , Sharaf Mufeed A. , Abdulqader Abbas Ahmed , Alhashimi Najah , Sherrhan Hassan , Chen Chen , Alsoufi Waleed , Ting Zeng Yun , Wei Xiao Li , Alhammadi Maged S.
Published: December 2022

Objectives: The purpose of this study was to three-dimensionally evaluate the relationship between the degree of bilateral impacted mandibular third molars (IM3M) angulation and the mandibular dental arch parameters in normal skeletal and dental malocclusion patients.
Materials and Methods: In this retrospective cross-sectional comparative study, 120 adult subjects’ cone beam computed tomography (CBCT) images were three-dimensionally analyzed. The sample was divided into four groups according to degree of M3M buccolingual angulation (BL°); Group A <12° on the center of the ridge (N=30), Group B 12-24° off-center of the ridge (N=40), Group C >24° off center of the ridge (N=30), and Group D (control group with normal erupted bilateral M3M).The study subjects were further also divided into three groups according to IM3M mesiodistal angulation (MD°); Group 1 from10° to 45°, Group 2> 45° and Group 3 (control group with normal erupted bilateral M3M, 0 -10°). Comparison within and between groups were performed using One-way ANOVA followed by Tukey's post hoc test, respectively. Correlation between IM3M, BL and MD angulation and mandibular arch parameter was calculated using Pearson's correlation coefficient.
Results: Statistically significant differences (P < .001) were founded between the IM3M BL° and anterior teeth inclination, arch length (AL) and inter second molar width (inter 2nd MW) as well as between the IM3M MD° with anterior crowding and the arch length (P < .001). Significant positive correlation was founded between IM3M BL° and anterior teeth inclination, and between IM3M MD° and anterior teeth crowding and inter 2nd MW. Significant negative correlation was observed between IM3M BL° and inter 1st MW and 2nd MW.
Conclusion: The degree of buccolingual and mesiodistal angulation of the impacted mandibular third molars was associated with mandibular dentoalveolar changes. The increase in buccolingual angulation is associated with increase of anterior teeth inclination, and the decrease of 1st and 2nd inter-molars width. The increase in mesiodistal angulations was associated with increase in anterior teeth crowding and 2nd inter-molars width.
Clinical relevance: Assessment of the relationship between the impacted mandibular third molars and the degree of arch discrepancy, and the position of mandibular incisors in the three planes of space might help in the decision-making process for extraction of the impacted third molars in adult patients.
Exploration on effect of thermal cycling treatment on mechanical and tribological performance of polyimide composites
Authors: Wang Yanming , Wang Yizheng , Wu Zhicheng , Zhang Xiaoliang , Li Feibo , Wang Guangshuo , Li Zongqi , Mu Jingbo , Li Ping , Zhang Zhixiao , Wang Zehu , Gao Xiaohong
Published: December 2022

Polyimide (PI) and PI composites reinforced with glass fiber (GF), and aramid fiber (AF) were fabricated with hot-pressing technology. And then polyimide and its composites were treated with thermal cycling (TC) condition from -50 ℃ to 150 ℃ with 300 cycles continuously. Compared with the samples without suffering from TC treatment, the fracture morphology, mechanics and tribological properties of the samples were studied. The results showed that, based on the fractographic morphologies, the phenomenon of fiber stripping could be obviously observed in the PI composite materials after TC treatment. And the bending modulus slightly decreased compared with the almost unchanged bending strength before and after TC treatment. Compared with before TC treatment, the friction coefficients (FC) and wear rates (WR) of PI and PI composites showed different variations respectively. In conclusion, TC treatment had a great influence on the morphologies of the worn surface and the composition of transfer film. As the shear force increases, the elemental analysis demonstrated that GF was extruded into the groove.
Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and naïve patients
Authors: Kotani Satoshi , Shibagaki Kotaro , Hirahara Noriyuki , Tanabe Ryo , Ebisudani Yuri , Nonomura Saya , Kishimoto Kenichi , Takahashi Yusuke , Kataoka Masatoshi , Oka Akihiko , Fukuba Nobuhiko , Mishima Yoshiyuki , Oshima Naoki , Kawashima Kousaku , Ishimura Norihisa , Araki Asuka , Kadota Kyuichi , Ishihara Shunji
Published: December 2022

Purpose
The incidence of gastric neoplasms in Helicobacter pylori (Hp)-naïve patients has recently increased due to a remarkable decrease in the Hp–infected population in Japan. We investigated the clinicopathologic differences between patients with Hp-infected gastric neoplasms (HpIGNs) and those with Hp-naïve gastric neoplasms (HpNGNs) that have not been fully elucidated so far.
Methods
This retrospective study investigated 887 patients with 1010 gastric dysplasia or cancers who underwent endoscopic or surgical treatment for the recent decade. Clinical and neoplastic features were compared between HpIGN and HpNGN cases.
Results
HpNGNs accounted for 4.5% (45/1010) of all gastric neoplasm cases, but were found concentratedly in the latter five-years. Nine hundred sixty-five HpIGNs included 774 differentiated-type and 191 undifferentiated-type. Forty-five HpNGNs included 4 undifferentiated type, 5 fundic-gland type, 32 foveolar type, 3 intestinal type, and 1 other differentiated type. HpNGNs occurred in significantly younger patients (59.9 vs. 71.8 years, p<0.05), were found more frequently in the proximal compartment (p<0.05), and had smaller size (median 3.0 vs. 20.0 mm, p<0.05). Histologically, HpNGNs also showed a lower prevalence of invasive cancer (13.3% vs. 41.7%, p<0.05) and lymphovascular invasion (2.2% vs. 34.9%, p<0.05) as compared with HpIGN cases. Nearly all HpNGNs (44/45, 97.8%) were diagnosed in the early pathological stage, while 17.8% (172/965) of HpIGNs were diagnosed in an advanced stage (p=0.058).
Conclusions
HpNGN occurrence has recently been increasing along with an increase in Hp-naïve population and in knowledge about this type of tumor, though with a lower grade of biological malignancy regardless of histologic type.
Study on Land Use in Towns from the Perspective of Ecological Security: a case study of Zhongtai Town, China
Authors: XU L. H. , XU D. , GU Z. F. , MA Q. W. , SHI Y. J. , WU Y. Q.
Published: December 2022

Context

Maintaining regional ecological security is necessary to ensure sustainable human survival and development. Starting with the goal of ecological security, optimal strategies for land use zoning can be developed. Previous studies have mainly focused on identifying ecological sources and ecological corridors, but the importance of ecological security in optimizing urban land use is seldom explored. In this study, a novel strategy for optimizing ecological security patterns (ESP) was proposed.

Objectives

To examine how to realize the zoning control of land use based on ESP .

Methods

We used an ESP model based on an ecological sensitivity evaluation, rain and flood models, MCR (Minimal Cumulative Resistance) model, and gravity model. Using these tools. And we assessed the ecological restoration, development, and construction of Zhongtai and proposed an optimized land use zoning management strategy.

Results

The establishment of the ESP of Zhongtai allowed for the characterization of the circulation of ecological sources in the region. This revealed 10 ecological sources, 9 important corridors, and 12 ordinary corridors. Recently, the study area has undergone a significant population increase and a rapid increase in urban land. But these built-up lands are concentrated in flood prone areas. Therefore, the construction of disaster prevention infrastructure should be prioritized during urban planning. Notably, the ecological corridors were mainly composed of tea plantations, farm land, mining land, and forest land, accounting for 80.45% of the total area. Ecological recovery can be carried out by mixed planting, returning farmland to forest, and prohibiting mining. In total, 71 ecological patches for restoration were identified, these were mostly mine lands flagged for restoration, but some were tea plantation optimization and illegal construction demolition areas. 61 controlled construction blocks were identified where strategies for ecological protection and food security should be applied, with priority use given to wastelands.

Conclusions

The ultimate goal of the study was to propose an optimized plan for controlled zoning of land use. Based on the ecological security and ecological sensitivity of the study area, four control zones were established: core protection area, ecological control area, restricted construction area, and suitable construction area. This controlled zoning strategy puts forward a clear management plan that ensures ecological protection and ecological restoration with optimal configurations and controlled construction designed to improve human health and livelihoods.
Robot-Assisted Lateral Pelvic Lymph Node Dissection in Patients with Advanced Rectal Cancer: A Single-center Experience of 65 Cases
Authors: Kim Eon Bin , Yoon Yong Sik , Kim Min Hyun , Kim Young Il , Lee Jong Lyul , Kim Chan Wook , Park In Ja , Lim Seok-Byung , Yu Chang Sik , Kim Jin Cheon
Published: December 2022

The treatment of lateral pelvic lymph node (LPLN) metastasis of rectal cancer has evolved because of technical difficulties from open surgery to laparoscopy and, recently, robot-assisted surgery. This study aimed to evaluate the technical feasibility and short- and long-term outcomes of robot-assisted LPLN dissection (LPND) following total mesorectal excision (TME) in advanced rectal cancer. Clinical data of 65 patients who underwent robotic-assisted TME with LPND from April 2014 to July 2022 were reviewed. Data regarding operative details, postoperative morbidity (within 90 postoperative days) for short-term outcomes and lateral recurrence as long-term outcomes were analyzed. Among the 65 patients with LPND, preoperative chemoradiotherapy was performed in 49 (75.4%). The mean operative time was 306.8 (range, 191–477) min, and the mean time of unilateral LPND was 38.6 (range, 16–66) min. LPND was bilaterally performed in 19 (29.2%) patients. The mean number of each side of harvested LPLNs was 6.8. Lymph node metastasis was observed in 15 (23.0%) patients, and 10 (15.4%) patients had postoperative complications. Lymphocele (n = 3) and pelvic abscess (n = 3) were the most common, followed by voiding difficulty, erectile dysfunction, obturator neuropathy, and sciatic neuropathy (all n = 1). During the 25 months of median follow-up, no lateral recurrence of the LPND site was noted. Robot-assisted LPND following TME is safe and feasible and showed acceptable short- and long-term outcomes. Despite some study limitations, we may be able to apply this strategy more widely through subsequent prospective controlled studies.
Genetic Algorithm based Approach to Solve the Clustered Steiner Tree Problem
Authors: Do Tuan Anh , Ban Ha-Bang , Huynh Thi Thanh Binh , Le Minh Tu , Nguyen Binh Long
Published: December 2022

In a complex network application, a set of nodes might be partitioned into multiple local clusters with different functions, properties, or communication protocols, and the communication is restricted between nodes of the same cluster to maximize efficiency and other security concern. Thus, there has been a rise in network design problems with additional constraints regarding the clustering of vertices, one of them being Clustered Steiner Tree Problem - a variant of the Steiner Tree Problem. Recently, a heuristic-based algorithm was proposed to solve the problem. However, its obtained result is limited in terms of solution quality when applied to the problem in the Euclidean case. This paper proposes a Genetic Algorithm called Shortest-Path Genetic Algorithm for solving the CluSteiner. In the proposal, a permutation-based individual representation that reduces the dimensionality of chromosomes to the number of clusters is devised. The proposed algorithm can solve the problem in both Euclidean and non-Euclidean cases. Experiment results compared to existing works in the literature are analyzed in detail to prove the effectiveness of the proposed algorithm.
The effect of six weeks of concurrent training (endurance-resistance) on the performance of the cardio-respiratory system in inactive young women
Authors: jabbari aysan , Gazalian farshad
Published: December 2022

Introduction: Inactive lifestyle is associated with decreased cardiorespiratory function and increased chronic non-communicable diseases and death. The aim of this study was to investigate the effect of six weeks of concurrent training (endurance-resistance) on the performance of the cardio-respiratory system in inactive young women.
Method: In this quasi-experimental study, 16 inactive women of Tehran city were selected in a targeted and available manner and were randomly placed in two control groups (n = 8) and concurrent exercise (endurance and resistance) (n = 8). After the pre-test (anthropometric tests and gas analyzer), the concurrent exercise group (endurance and resistance) performed the concurrent exercise program for six weeks and three sessions every week, and the subjects of the control group did not have any special exercise. After the six-week training period, measuring anthropometric indices (body mass index (BMI), body fat percentage (PBF), muscle mass (SMM) and hip-to-waist ratio (WHR) and cardiorespiratory indices including (the first ventilatory threshold (VE/VO2), Second ventilatory threshold (VE/VCO2), maximum oxygen consumption (VO2max), respiratory exchange ratio (RER), heart rate (HR), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), expiratory volume forced in one second to forced capacity (FEV1/FVC) and the ratio of oxygen consumption to heart rate (VO2/HR) was done using in-body device and gas analyzer. The data were analyzed by covariance analysis test at the P<0.05.
Results: The results showed that six weeks of concurrent training (endurance-resistance) had no significant effect on the values ​​of VO2max, FEV1, FVC, VE/VO2, VE/VCO2, FEV1/FVC, VO2/HR,HR in inactive young women (P<0.05). Also, after the training period, there was no difference in BMI, PBF, SMM and WHR indices between the training and control groups (P<0.05).
Conclusion: According to the results of the research, it seems that six weeks of concurrent training (endurance-resistance) does not affect the performance of the cardio-respiratory system in inactive young women.
A FHIR has been lit on gICS – Facilitating the standardized exchange of informed consent in a large network of university medicine
Authors: Bialke Martin , Geidel Lars , Hampf Christopher , Blumentritt Arne , Penndorf Peter , Schuldt Ronny , Moser Frank-Michael , Lang Stefan , Werner Patrick , Stäubert Sebastian , Hund Hauke , Albashiti Fady , Gührer Jürgen , Prokosch Hans-Ulrich , Bahls Thomas , Hoffmann Wolfgang
Published: December 2022

Background

The Federal Ministry of Education and Research of Germany (BMBF) funds a network of university medicines (NUM) to support COVID-19 and pandemic research at national level. The “COVID-19 Data Exchange Platform” (CODEX) [1] as part of NUM establishes a harmonised infrastructure that supports research use of COVID-19 datasets. The broad consent (BC) of the Medical Informatics Initiative (MII) is agreed by all German federal states and forms the legal base for data processing. All 34 participating university hospitals (NUM sites) work upon a harmonised infrastructural as well as legal basis for their data protection-compliant collection and transfer of their research dataset to the central CODEX platform.
Each NUM site ensures that the exchanged consent information conforms to the already-balloted HL7 FHIR consent profiles and the interoperability concept of the MII Task Force “Consent Implementation” (TFCI).
The Independent Trusted Third-Party (TTP) of the University Medicine Greifswald supports data protection-compliant data processing and provides the consent management solutions gICS.

Methods

Based on a stakeholder dialogue a required set of FHIR-functionalities was identified and technically specified supported by official FHIR experts. Next, a “TTP-FHIR Gateway” for the HL7 FHIR-compliant exchange of consent information using gICS was implemented. A last step included external integration tests and the development of a pre-configured consent template for the BC for the NUM sites.

Results

A FHIR-compliant gICS-release and a corresponding consent template for the BC were provided to all NUM sites in June 2021. All FHIR functionalities comply with the already-balloted FHIR consent profiles of the HL7 Working Group Consent Management. The consent template simplifies the technical BC rollout and the corresponding implementation of the TFCI interoperability concept at the NUM sites.

Conclusions

This article shows that a HL7 FHIR-compliant and interoperable nationwide exchange of consent information could be built using of the consent management software gICS and the provided TTP-FHIR Gateway. The initial functional scope of the solution covers the requirements identified in the NUM-CODEX setting. The semantic correctness of these functionalities was validated by project-partners from the Ludwig-Maximilian University in Munich. The production rollout of the solution package to all NUM sites has started successfully.
Multi-product model for assessing the effectiveness of the safe operation of enterprises
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Alimkhanova A. N. , Mitsel A. A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

The concept of efficiency is very important in economic science, and today it has its increasing role in each sector of the economy. The evaluation of the efficiency of the enterprise allows to carry out a faithful and advantageous resource allocation strategy, and shows its potential level. There are various methods and models for assessing the efficiency of enterprises. This paper presents an assessment of the efficiency of enterprises by the Stochastic Frontier Analysis method. The results of the work showed how the efficiency of various enterprises of same industry will change in several years. It is shown that such a model can be used to assess the financial stability and bankruptcy prediction.
Calculation of signal attenuation of 5G cellular networks for frequencies of the FR1 band
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Movchan A. K. , Rogozhnikov E. V. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Dmitriev E. M. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Novichkov S. A. ,   Skoltech, Lakontsev D. V. ,   Skoltech
Published: December 2022

The paper presents a model for the propagation of a radio signal of a fifth-generation cellular communication system, taking into account the unevenness of the terrain. The aim of the study is to assess the signal power level on the receiving side of the fourth and fifth generation cellular communication system when the signal propagates over uneven terrain in the frequency bands FR1 (2.6 GHz), FR1 (4.9 GHz). When estimating the power of the radio signal on the receiving side in the model, the values of the height map of the of Tomsk city, obtained in the course of the SRTM3 program, were used as uneven terrain. The presented radio signal propagation model is the Longley Rice ITM (Irregular Terrain Model). For this model, the main expressions are given that determine the resulting signal attenuation, as well as expressions that describe the geometry of the propagation path. The article reflects the main factors that determine the propagation of centimeter waves characteristic of the fifth generation cellular communication system, presents the results of modeling the propagation of the fifth 5G and fourth 4G generation cellular signal using the example of various scenarios for the location of a subscriber terminal and a base station in the Tomsk city. The simulation was carried out for two frequency bands FR1 (4.9 GHz) of the 5G network and FR1 (2.6 GHz) of the 4G network. As a result of the simulation, the values of the attenuation of the signal power level during propagation along the given paths were obtained, and also, taking into account the parameters of the transceiver equipment, the values of the signal power on the receiving side were calculated. Based on the data obtained, a comparative assessment of the communication range for 4G and 5G systems was made.