bluuebunny/crossref_metadata_2025 huggingface dataset:
Inter-Firm Social Networks Created by Mobile Laborers: A Case Study on Siteler in Ankara
Authors: Beyhan Burak
Published: September 2020

Labor mobility, both as a mechanism of knowledge diffusion and as a kind of social glue that holds together small production communities operative within a given territory, deserves serious consideration. In this context, focusing on a specific industrial cluster in Ankara, this paper reveals the extent and characteristics of the social networks created by the mobile laborers in order to understand the interconnections between social context, knowledge spillovers, innovation and labor mobility. For this purpose a step-wise algorithm is employed in order to identify social sub-groups by employing social network analysis and by drawing on the flow data constructed for this study. What is evident from this study is that the social network created by the mobility of laborers in Siteler, an industrial cluster specialized in furniture production, reveals a topography of social relations that cannot be split into equally large blocks but eventually parceled out to micro parts consisting of generally 2 or 3 firms. Interestingly, the contexts of innovation also unveil that innovative firms tend to be located at an intermediate position, not an upper and central position, within the topography of the network.
INFLUÊNCIA DOS MÉTODOS DE CONTROLE DA LAGARTA-DO-CARTUCHO SOBRE O DESENVOLVIMENTO E PRODUÇÃO DE MILHO
Authors: Dos Santos Jailma Rodrigues , Maia Ana Gabriela de Freitas , Da Costa Andreza Ferreira , De Godoy Maurício Sekiguchi , Silva Raimundo Ivan Remígio
Published: September 2020

A cultura do milho é atacada por diversas espécies de insetos, sendo a Spodoptera frugiperda Smith a praga mais prejudicial, acarretando nível de dano econômico. Objetivou-se com o trabalho avaliar o desenvolvimento da planta e a produção do milho-verde após aplicação de técnicas controle da lagarta-do-cartucho. O experimento foi conduzido a campo com o milho híbrido Agroceres (AG 1051) em consórcio com feijão “paulistinha”. Utilizou-se delineamento inteiramente casualizado com quatro repetições, com os tratamentos (TI = inseticida Lannate BR + Certero; TII = bactéria Bacillus thuringiensis; TIII = fertilizante Matrix com poder de inseticida e TIV = aplicação de água - testemunha). Estudou-se os estágios de desenvolvimento da cultura, aos 45 e 70 dias após a emergência (DAE) e produção. Para as fases de desenvolvimento aos 45 e 70 DAE, não houve diferença entre os tratamentos para altura da planta e número de folhas verdes. Já para área foliar e diâmetro do colmo aos 45 dias, os tratamentos TI e TII foram superiores aos demais e aos 70 DAE não observou-se diferença entre os tratamentos. Na avaliação de produção, a quantidade de espiga por planta, comprimento da espiga, diâmetro da espiga, peso da espiga empalhada e despalhada e número de grão, não diferiram estatisticamente entre os tratamentos. Concluiu-se que os controles químico e biológico apresentaram melhores respostas para área foliar e diâmetro do colmo no desenvolvimento das plantas aos 45 DAE. Nas variáveis de produção todos os tratamentos se comportaram de forma igualitária, mostrando que características padrões não foram afetadas.
Comportamento do consumidor em relação a produtos sustentáveis: uma revisão sistemática de literatura
Authors: Damázio Luciana Faluba , Coutinho Leonardo Antunes Nogueira , Shigaki Helena Belintani
Published: September 2020

Este artigo tem por objetivo realizar uma revisão sistemática de literatura sobre o comportamento do consumidor em relação aos produtos sustentáveis, a fim de identificar os fatores que interferem no comportamento, bem como definir os atributos e a percepção do consumidor frente ao tema sustentabilidade. Identificou-se mais de 4600 textos a partir da revisão, conduzida em 22 bases acadêmicas e practitioners. A partir dos critérios de inclusão e exclusão, 219 artigos foram selecionados e, desses, 95 foram totalmente analisados. Como resultado, foram identificados onze fatores de influência nas práticas de sustentabilidade no comportamento do consumidor de produtos sustentáveis (ambiente, idade, nível educacional, classe econômica, gênero, consciência, preocupação com a própria imagem, emoção, acesso à informação, confiança e hábito) e sete em relação aos atributos e percepção do consumidor acerca de sustentabilidade (eco-friendly, garantia de origem, saúde do consumidor, fair trade, teste em animais, recicláveis e ingredientes naturais).
Analyzing the conditional behavior of rainfall deficiency and groundwater level deficiency signatures by using copula functions
Authors: Tahroudi Mohammad Nazeri , Ramezani Yousef , De Michele Carlo , Mirabbasi Rasoul
Published: September 2020

The complex hydrological events such as storm, flood and drought are often characterized by a number of correlated random variables. Copulas can model the dependence structure independently of the marginal distribution functions and provide multivariate distributions with different margins and the dependence structure. In this study, the conditional behavior of two signatures was investigated by analyzing the joint signatures of groundwater level deficiency and rainfall deficiency in Naqadeh sub-basin in Lake Urmia Basin using copula functions. The study results of joint changes in the two signatures showed that a 90–135 mm reduction in rainfall in the area increased groundwater level between 1.2 and 1.7 m. The study results of the conditional density of bivariate copulas in the estimation of groundwater level deficiency values by reducing rainfall showed that changes in values of rainfall deficiency signature in the sub-basin led to the generation of probability curves of groundwater level deficiency signature. Regarding the maximum groundwater level deficiency produced, the relationship between changes in rainfall deficiency and groundwater level deficiency was calculated in order to estimate the groundwater level deficiency signature values. The conditional density function presented will be an alternative method to the conditional return period.
Brines from industrial water recycling: new ways to resource recovery
Authors: Kieselbach Malena , Hogen Tobias , Geißen Sven-Uwe , Track Thomas , Becker Dennis , Rapp Hans-Jürgen , Koschikowski Joachim , Went Joachim , Horn Harald , Saravia Florencia , Bauer Annika , Schwantes Rebecca , Pfeifle Daniel , Heyn Nicolas , Weissroth Miriam , Fitzke Bernd
Published: September 2020

Stricter environmental regulation policies and freshwater as an increasingly valuable resource have led to global growth of zero liquid discharge (ZLD) processes in recent years. During this development, in addition to water, the recovery of recyclable materials, e.g. salts, from industrial wastewater and brines is considered more frequently. Within the framework of the HighCon research project, the subject of this study, a new ZLD process with the goal of pure single-salt recovery from industrial wastewater has been developed and investigated in a demonstrational setup at an industrial site. With regard to pure salts recovery, separating organic components is of great importance during the treatment of the concentrate arising from used water recycling. The removal of COD and of ions responsible for scaling worked very well using nanofiltration. The nanofiltration permeate containing the monovalent ions was pre-concentrated using electrodialysis and membrane distillation before selective crystallization for single-salt recovery was performed. An example economic case study for the newly developed ZLD process – based on demonstration results and considering optimization measures for a full-scale design – indicates that the costs are equal to those of a conventional ZLD process, which, however, does not provide inter alia the aforementioned benefit of single-salt recovery.
Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review
Authors: Baveloni Franciele Garcia , Riccio Bruno Vincenzo Fiod , Di Filippo Leonardo Delello , Fernandes Mariza Aires , Meneguin Andréia Bagliotti , Chorilli Marlus
Published: September 2020

Administration of substances through the skin represents a promising alternative, in
relation to other drug administration routes, due to its large body surface area, in order to offer
ideal and multiple sites for drug administration. In addition, the administration of drugs
through the skin avoids the first-pass metabolism, allowing an increase in the bioavailability
of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises
the main barrier of protection against external agents, mainly due to its structure, composition
and physicochemical properties, becoming the main limitation for the administration of substances
through the skin. In view of the above, pharmaceutical technology has allowed the
development of multiple drug delivery systems (DDS), which include liquid crystals (LC),
cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins
(CD) and dendrimers (DND). It appears that the DDS circumvents the problems
of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well
as optimizing the therapeutic effect locally. This review aims to highlight the DDS that include
LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin
therapies.
Prospects for the Use of Sialidase Inhibitors in Anti-atherosclerotic Therapy
Authors: Sobenin Igor A. , Markin Alexander M. , Glanz Victor Y. , Markina Yuliya V. , Wu Wei-Kai , Myasoedova Veronika A. , Orekhov Alexander N.
Published: September 2020

The most typical feature of atherogenesis in humans at its early stage is the formation
of foam cells in subendothelial arterial intima, which occurs as the consequence of
intracellular cholesterol deposition. The main source of lipids accumulating in the arterial
wall is circulating low-density lipoprotein (LDL). However, LDL particles should undergo
proatherogenic modification to acquire atherogenic properties. One of the known types of
atherogenic modification of LDL is enzymatic deglycosilation, namely, desialylation, which
is the earliest change in the cascade of following multiple LDL modifications. The accumulating
data make sialidases an intriguing and plausible therapeutic target, since pharmacological
modulation of activity of these enzymes may have beneficial effects in several pathologies,
including atherosclerosis. The hypothesis exists that decreasing LDL enzymatic
desialylation may result in the prevention of lipid accumulation in arterial wall, thus breaking
down one of the key players in atherogenesis at the cellular level. Several drugs acting
as glycomimetics and inhibiting sialidase enzymatic activity already exist, but the concept
of sialidase inhibition as an anti-atherosclerosis strategy remains unexplored to date. This
review is focused on the potential possibilities of the repurposing of sialidase inhibitors for
pathogenetic anti-atherosclerotic therapy.
Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility
Authors: Beygi Zahra , Forouhari Sedighe , Mahmoudi Elahe , Hayat Seyed M.G. , Nourimand Firoozeh
Published: September 2020

Nearly 15% of couples experience infertility as a universal health issue. About
50% of infertility cases have been known to be associated with the male partner .
Oxidative stress (OS) represents an imbalance in the level of reactive oxygen species
(ROS) and anti-oxidants. In fact, OS has been considered as one of the popular
pathologies reported in about 50% of all infertile males. Therefore, the increased level of
ROS may result in infertility via DNA damages or lipid peroxidation (LPO) as well as the
inactivation of enzymes and oxidation of protiens in spermatozoa. Basically, OS results
from lifestyle variables. As the absence of antioxidants and the respective deficiencies in
the semen cause OS, variations in the lifestyle and anti-oxidant regimes may be
advantageous to treatment strategies for resolving such an issue. Actually, anti-oxidants
like vitamins E and C, glutathione, coenzyme-Q10, carnitines, selenium, Nacetylcysteine,
carotenoids, zinc, and pentoxifylline decline the OS-induced sperm
damages. Therefore, the present review overviews the oxidative biochemistry
associated with sperm health and identifies which men would be most at risk of
oxidative infertility. Hence, the review would show the techniques provided to diagnose
OS and diverse therapeutic options.
Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility
Authors: de Lourdes Ochoa-González Fátima , González-Curiel Irma E. , Cervantes-Villagrana Alberto R. , Fernández-Ruiz Julio C. , Castañeda-Delgado Julio E.
Published: September 2020

Diabetes is a chronic disease characterized by marked alterations in the
metabolism of glucose and by high concentrations of glucose in the blood due to a
decreased insulin production or resistance to the action of this hormone in peripheral
tissues. The International Diabetes Federation estimates a global incidence of diabetes
of about 10% in the adult population (20 - 79 years old), some 430 million cases
reported worldwide in 2018. It is well documented that people with diabetes have a
higher susceptibility to infectious diseases and therefore show higher morbidity and
mortality compared to the non-diabetic population. Given that the innate immune
response plays a fundamental role in protecting against invading pathogens through a
myriad of humoral and cellular mechanisms, the present work makes a comprehensive
review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as
well as a brief description of the molecular events leading or associated to such
conditions. We show that in these patients a compromised innate immune response
increases susceptibility to infections.
Mini-Review; Deriving Avian Stem Cells by Small Molecules
Authors: Farzaneh Maryam
Published: September 2020

Avian embryos and related cell lines have found wide applications in basic and applied
sciences. The embryonated egg is a great host for monoclonal antibodies and recombinant proteins.
Avian cell lines derived from embryonated eggs have been used for the production of transgenic
birds and virus inoculation in vaccine preparation. Hitherto, many efforts have been invested to develop
efficient avian stem cell culture. Under the conventional conditions, there are various challenges,
such as the type of feeder layers, conditioned medium, serum, and growth factors. Researchers
have investigated different conditions to solve these problems. Recent studies have shown that
targeted strategies using small molecule inhibitors could be used as alternatives to multi-growth factor
delivery approaches. Since small molecule inhibitors were used for mammalian pluripotent
stem cells (PSC), several kinds of research have examined the effect of the small molecule on self-
-renewal and maintenance of avian PSC. Avian PSC can be derived from early blastodermal cells
(stage X), circular primoridial germ cells (PGC; stage HH17), gonadal PGC (stage HH28), and embryonic
germ cells (EGC; HH28). Previous studies have shown that the use of small molecule
drugs such as PD0325901, SB431542, SC1, IDE1, Z-VAD, Blebbistatin, H-1152, and IDE1 could
be an efficient method for the derivation of avian stem cells. This mini-review covers the recent development
of avian stem cell culture by small molecules.
Formulation, Optimization, and Ex-vivo Evaluation of Novel Lipid Carriers for Enhanced Transdermal Delivery of Hydroquinone
Authors: Verma Shivani , Kaur Sukhjinder , Kumar Lalit
Published: September 2020

Background:

HQ is used for hyper-pigmentation treatment using conventional creams and
gels. These formulations show various disadvantages like poor skin permeation, allergic reactions, and
repeated use and decreasing patient compliance.

Objectives:

The present work involved formulation, statistical optimization, and characterization of
Nanostructured Lipid Carriers (NLCs) for efficient topical delivery of hydroquinone (HQ) for hyperpigmentation
treatment.

Methods:

The NLCs were optimized exploring Box–Behnken Design (BBD) using three independent
variables and two dependent variables. Formulation having the minimum size and maximum drug entrapment
was considered as optimized formulation. The optimized formulation was evaluated for drug
release followed by its freeze-drying. The freeze-dried formulation was subjected to Differential Scanning
Calorimetry (DSC) analysis, X-Ray Diffraction (XRD) analysis, and Fourier Transform-Infrared
spectroscopy (FT-IR) analysis. Furthermore, NLCs based gel was prepared by using Carbopol 934 as a
gelling agent. NLCs based gel was evaluated for skin permeation, skin retention, and skin distribution
(through confocal microscopic analysis) using pig ear skin.

Results:

Optimized NLCs showed smaller particle size [(271.9 ± 9) nm], high drug entrapment [(66.4 ±
1.2) %], tolerable polydispersity index (PDI) (0.221 ± 0.012), and zeta potential [(-25.9 ± 1.2) mV]. The
FT-IR analysis revealed excellent compatibility between HQ and other excipients. The Carbopol 934
gel containing NLCs showed high transdermal flux [(163 ± 16.2) μg/cm2/h], permeability coefficient
(0.0326 ± 0.0016), and skin permeation enhancement ratio (3.7 ± 0.4) compared to marketed cream of
HQ. The results of confocal microscopic (CLSM) analysis revealed the accumulation of optimized
NLCs in the lower epidermal layers of skin.

Conclusion:

NLCs based gel was considered effective in the topical delivery of HQ to treat hyperpigmentation
due to high skin permeation, skin retention, and prolonged release of HQ.
Position and Pose Measurement of 3-PRS Ankle Rehabilitation Robot Based on Deep Learning
Authors: Chen Guoqiang , Zhou Hongpeng , Huang Junjie , Liu Mengchao , Bai Bingxin
Published: September 2020

Introduction:

The position and pose measurement of the rehabilitation robot plays a very important role in patient
rehabilitation movement, and the non-contact real-time robot position and pose measurement is of great significance.
Rehabilitation training is a relatively complicated process, so it is very important to detect the training process of the
rehabilitation robot in real time and accuracy. The method of the deep learning has a very good effect on monitoring the
rehabilitation robot state.

Methods:

The structure sketch and the 3D model of the 3-PRS ankle rehabilitation robot are established, and the
mechanism kinematics is analyzed to obtain the relationship between the driving input - the three slider heights - and the
position and pose parameters. The whole network of the position and pose measurement is composed of two stages: (1)
measuring the slider heights using the CNN based on the robot image and (2) calculating the position and pose parameter
using the BPNN based on the measured slider heights from the CNN. According to the characteristics of continuous
variation of the slider heights, a regression CNN is proposed and established to measure the robot slider height. Based on
the data calculated by using the inverse kinematics of the 3-PRS ankle rehabilitation robot, a BPNN is established to solve
the forward kinematics for the position and pose.

Results:

The experimental results show that the regression CNN outputs the slider height and then the BPNN accurately
outputs the corresponding position and pose. Eventually, the position and pose parameters are obtained from the robot
image. Compared with the traditional robot position and pose measurement method, the proposed method has significant
advantages.

Conclusion:

The proposed 3-PRS ankle rehabilitation position and pose method can not only shorten the experiment
period and cost, but also get excellent timeliness and precision. The proposed approach can help the medical staff to
monitor the status of the rehabilitation robot and help the patient rehabilitation in training.

Discussion:

The goal of the work is to construct a new position and pose detection network based on the combination of
the regression convolutional neural network (CNN) and the back propagation neural network (BPNN). The main
contribution is to measure the position and pose of the 3-PRS ankle rehabilitation robot in real time, which improves the
measurement accuracy and the efficiency of the medical staff work.
Analysis and Fitting of a Thorax Path Loss Based on Implantable Galvanic Coupling Intra-Body Communication
Authors: Zhang Shuang , Li Yao , Yu Yuanyu , Kuang Jiang-ming , Yang Jining , Wang Jiujiang , Liu Yihe
Published: September 2020

Objective:

The aim of this research was to study the channel transmission characteristics
of living and dead animal bodies and signal path loss characteristics of implantable communication
in the axial direction.

Methods:

By injecting fentanyl citrate injection solution, we kept the research object (a piglet) in a
comatose state and then a death state, so as to analyze the channel characteristics in each state. To
analyze channel gain when using an implantable device with a fixed implantation depth and varying
the axial distance, we proposed an implantable two-way communication path loss model.

Results:

Comparing the living-body and dead-body results showed that the channel gain difference was approximately
10dB for the same position and distance; heartbeat, pulse and breathing of the living animal contributed approximately
1dB of noise. Analyzing the calculated and experimental results of the path loss model showed that the determination
correlation coefficients of the model were 0.999 and 0.998, respectively. The model prediction result and the experimental
verification result also agreed closely.

Conclusion:

The path loss model not only fits the experimental results, but also has better predictability for those
positions not measured.
“Use Positive Reframing, Not Behavioural Disengagement” Coping Strategy for Caregivers of Palliative Cancer Patients
Authors: Nor Hadi Noor Melissa , Ahmad Fazlina , Isa Mohamad Rodi , Razali Salmi
Published: September 2020

Caregivers of palliative cancer patients (CPCP) who are depressed put both the patients and them at risk for serious physical and psychological complications. This study investigated the prevalence of depression and it's contributing factors among the CPCP in Malaysia using the diagnostic tool and validated questionnaires. About 6% of CPCPs was diagnosed to have a major depressive disorder (MDD). Coping by ‘behavioural disengagement’ increased the odds for MDD while using ‘positive reframing’ was protective for MDD. The CPCP should be trained with beneficial types of coping strategy to help them reduce the burden of caregiving and to ensure optimum mental health status.
Liječenje prijeloma proksimalnog dijela pete metatarzalne kosti kod sportaša
Authors: Japjec Mladen , Šebečić Božidar , Starešinić Mario , Dujmović Tomislav , Bagić Ivan , Zlodi Valentino , Jurina Andrija , Štivičić Josip
Published: September 2020

Cilj: Usporediti rezultate konzervativnog i operativnog liječenja prijeloma proksimalnog dijela pete metatarzalne (V MT) kosti kod sportaša. Ovi prijelomi predstavljaju velik dijagnostički i terapijski izazov. Uobičajeno su podijeljeni u 3 zone: tuberozitas (zona I), metafiza (zona II) i proksimalna dijafiza (zona III). Radi kompromitirane cirkulacije karakterizira ih otežano i dugotrajno cijeljenje koje nerijetko završava razvojem pseudartroze, naročito kod mladih i fizički aktivnih osoba. Ispitanici i metode: U Kliničkoj bolnici Merkur u periodu od 13 godina liječen je 61 sportaš s ukupno 65 prijeloma V MT kosti u zoni II i III. Svi ostali pacijenti isključeni su iz promatranja. Pacijenti su podijeljeni u 2 skupine: Skupina 1 – operativno liječeni i Skupina 2 – konzervativno liječeni prijelomi. U Skupini 1 bilo je 50 (77 %) prijeloma, a u Skupini 2 15 (23 %) prijeloma. Za osteosintezu je u početku studije korišten klasični maleolarni vijak koji je radi komplikacija u kasnijem tijeku studije zamijenjen debljim intramedularnim vijkom. Rezultati liječenja praćeni su radiološkim i kliničkim pregledom, a evaluirani Modified Foot scoreom (MFS). Rezultati: Period praćenja iznosio je u prosjeku 12 mjeseci. U Skupini 1 većina prijeloma je sanirana u periodu od 8 tjedana. Produženo cijeljenje bilo je prisutno kod 7 (14 %) prijeloma. U kasnijem rehabilitacijskom periodu 3 pacijenta (6 %) imala su refrakturu koja je riješena reoperacijom i postavljanjem jačeg vijka. U Skupini nisu zarasla 2 prijeloma, 7 (46 %) prijeloma zaraslo je u periodu od 6 mjeseci, a 5 (33 %) od njih naknadno je operirano. U konačnici su svi operirani prijelomi zarasli. S obzirom na MFS, Skupina 1 u odnosu na Skupinu 2 imala je statistički značajno (p < 0,01) bolji rezultat. Zaključak: Dobra dijagnostika i klasifikacija prijeloma te operativno liječenje prijeloma metafize i proksimalne dijafize garantira brzo cijeljenje i rani povratak punoj sportskoj aktivnosti.
Extensor digitorum tendon rupture after anterior ankle arthroscopy
Authors: Šumanovac Antun , Selthofer Robert , Kokić Tomislav , Mujkić Robert
Published: September 2020

Aim: The aim of this paper is to increase awareness of orthopaedic surgeons about an uncommon yet possible complication of ankle arthroscopy – iatrogenic extensor digitorum rupture. Ankle arthroscopy is becoming more widespread and according to the literature, the complication rate varies from 9% up to 17%. Case report: We are presenting a case of 32-year old police officer who recreationally plays soccer. The patient presented with clear signs of anterior ankle impingement confirmed by X-ray and the MRI. During ankle arthroscopy massive tibial and talar bone spurs were found with significant synovial reaction, nearly 10 loose intraarticular bodies and syndesmotic ossification. The patient was placed in a walking boot and early postoperative recovery went as planned. Physical therapy started 14 days after the procedure. Five weeks after the surgery while dorsiflexing his fingers patient felt a "snap" over his ankle followed by swelling. He couldn't dorsiflex his fingers afterwards. MRI showed a rupture of the common extensor digitorum tendon. The patient was treated with open reconstruction of the tendon and lower leg immobilisation for 6 weeks followed by physical therapy and partial weight bearing. The patient made a full recovery. Conclusion: It is of the utmost importance to keep in mind that ankle arthroscopy alongside it's obvious benefits is not void of complications. Iatrogenic tendon lesion is always possible and should be suspected with any loss of movement in foot and ankle after the procedure. Urgent MRI and immediate reconstruction showed good results in our case.
Učinak liječenja osteoartritisa koljenskog zgloba primjenom matičnih stanica
Authors: Rapan Vjeran , Rapan Domagoj , Rapan Saša
Published: September 2020

Cilj: Svrha istraživanja bila je ispitati učinkovitost liječenja osteoartritisa koljenskoga zgloba uporabom matičnih stanica. Ispitanici i metode: U ispitivanje je bilo uključeno 10 pacijenata s artrozom drugog stupnja, koji su operirani u Odjelu za ortopediju Kliničkog bolničkog centra Osijek. Prijeoperacijski pacijenti obrađeni su standardnom radiološkom snimkom koljena, te uz pomoć MRI-ja. Graft dobiven liposukcijom centrifugiran je i pomiješan s plazmom bogatom trombocitima (PRP) te je potom apliciran u oboljeli zglob. Tri mjeseca nakon procedure s pacijentima smo telefonski kontaktirali, a dobiveni podaci su statistički obrađeni. Rezultati: Nakon 3 mjeseca od aplikacije matičnih stanica u koljenski zglob postoji statistički značajno poboljšanje ako se prati oteklina zgloba, bol pri stajanju na mjestu, bol pri hodanju po ravnoj podlozi, bol pri hodanju uz stepenice. Zaključci: Iako je naše istraživanje provedeno na malom broju ispitanika, a vrijeme praćenja bilo relativno kratko, pacijenti su pokazali značajno funkcionalno poboljšanje kliničkih tegoba. Potrebna su daljnja istraživanja i praćenja kako bi se donijele smjernice u liječenju ovom metodom, dužim praćenjem i većim brojem ispitanika.
Efek Pendinginan Cepat (Quenching) Terhadap Sifat Fisis Kawat Nano Perak Yang Disintesis Menggunakan Metode Polyol
Authors: Saputra Muhamad Wahyudi , Sembiring Simon , Junaidi Junaidi
Published: September 2020

Penelitian tentang pengaruh quenching terhadap sifat fisis AgNWs telah dilakukan. AgNWs disintesis menggunakan metode polyol pada suhu 130˚C selama 2 jam. Sintesis AgNWs dilakukan dengan memvariasikan suhu medium quenching pada suhu 27˚C, 0˚C, dan -80˚C. Kemudian AgNWs diuji getar selama 45 menit untuk mengetahui kekuatan mekaniknya. Hasil uji Scanning Electron Microscopy (SEM) menunjukkan bahwa AgNWs yang di-quenching pada suhu 27˚C mengalami perubahan panjang dari (40 ± 10) µm ke (21 ± 6) µm, pada suhu 0˚C dari (37 ± 8) µm ke (24 ± 8) µm, dan pada suhu -80˚C dari (34 ± 9) µm ke (29 ± 10) µm. Diameter AgNWs yang diquenching pada suhu 27˚C sebelum dan setelah digetar memiliki ukuran (200 ± 10) nm menjadi (210 ± 10) nm, pada suhu 0˚C memiliki diameter (224± 4) nm menjadi (239 ± 8) nm, dan pada suhu -80˚C memiliki diameter (253 ± 6) nm menjadi (270 ± 10) nm. Semakin rendah suhu medium quenching menurunkan ukuran panjang dan meningkatkan kekuatan mekanik AgNWs. Spektrum Uv-Vis AgNWs menunjukkan puncak absorbansi pada panjang gelombang 348 nm dan 411-425 nm. Hasil TGA menunjukkan bahwa AgNWs yang di-quenching pada suhu -80˚C memiliki kestabilan termal yang lebih baik dengan menunjukkan kehilangan massa sekitar 2,88%, sedangkan pada suhu quenching 27˚C dan 0˚C menunjukkan kehilangan massa sebesar 8,73% dan 4,17%.
Pengembangan Rekam Medis Elektronik Berbasis Software as a Service (SaaS) bagi Dokter Praktik Mandiri
Authors: Santoso Dian Budi , Nuryati Nuryati , Pramono Angga Eko
Published: September 2020

Latar Belakang: Klinik dokter praktik mandiri di Indonesia, khususnya yang telah menjadi mitra BPJS Kesehatan telah terbiasa menggunakan sistem berbasis elektronik. Namun software yang disediakan oleh BPJS Kesehatan tersebut belum mampu menggantikan fungsi rekam medis di klinik dokter praktik mandiri karena beberapa keterbatasan. Di Indonesia, saat ini belum ada software rekam medis elektronik yang dapat digunakan baik untuk pasien umum maupun pasien BPJS Kesehatan serta asuransi kesehatan lain dengan konsep Software as a Service (SaaS).Tujuan: Mengembangkan sistem rekam medis elektronik berbasis SaaS bagi dokter praktik mandiri di Indonesia.Metode: Jenis penelitian ini adalah research and development dengan mengikuti tahapan pengembangan sistem informasi menggunakan metode prototyping. Subyek penelitian adalah dokter praktik mandiri di Daerah Istimewa Yogyakarta berjumlah 25 orang. Data kualitatif dikumpulkan dengan wawancara dan FGD pada tahap analisis kebutuhan. Data kuantitatif dikumpulkan dengan kuesioner pada tahap uji coba dan evaluasi.Hasil: Rekam medis elektronik harus dapat menyimpan dan menampilkan riwayat penyakit terdahulu, riwayat alergi, dan riwayat kunjungan pasien ke klinik dokter praktik mandiri serta interoperable dengan p-Care BPJS Kesehatan. Hasil evaluasi menunjukkan semua responden setuju terhadap aspek system usefulness, information quality, dan interface quality.Kesimpulan: Prototype rekam medis elektronik bagi dokter praktik mandiri telah dikembangkan dengan konsep SaaS dan responden merasa puas terhadap prototype yang telah dikembangkan.
Source Related Argumentation Found in Science Websites
Authors: Barnes Ralph , Neumann Zoë , Draznin-Nagy Samuel
Published: September 2020

In this paper, we consider the way that web documents seeking to persuade readers of certain science claims provide information about the sources of the arguments. Our quantitative analysis reveals that web documents in our sample include hundreds of examples in which the reader is provided information regarding the trustworthiness (or lack thereof) of sources. The web documents also contain a large number of examples in which the reader is provided with information about how many individuals hold a particular belief. We discuss ad hominem, ad verecundiam, and ad populum arguments, and the way that the examples found in our sample of documents are related to these argumentation schemes.
Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin
Authors: Lestari Febia Arien , Hajrin Wahida , Hanifa Nisa Isneni
Published: September 2020

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.
Introdução de “Elites e trabalho no Brasil e no Uruguai: as origens do debate atual”
Authors: Ranincheski Sônia Maria
Published: September 2020

Este livro é uma reflexão sociológica sobre o posicionamento das elites parlamentares brasileiras e uruguaias em relação as leis trabalhistas no começo do século XX. É uma contribuição para o debate atual e polêmico sobre como conduzir uma sociedade no qual há cada vez menos exigências de trabalho humano e as crises econômicas empurram a soluções drámaticas como fim de leis trabalhistas. O tema das leis de trabalho atualmente retorna como uma tragicomédia de busca de soluções para a crise nas quais presenciamos o inusitado da defesa dos trabalhadores pelo emprego a qualquer preço a qualquer situação. Retornar ao começo do século XX e às polêmicas para implantação das primeiras leis trabalhistas contribui para perceber vis a vis o drama atual da sociedade latinoamericana e em especial Brasil e Uruguai.
Anaesthetic Management of a Case of Peritonsillar Abscess in a Patient with Complete Heart Block with Pacemaker
Authors: M. Dr. Amukthamalyada , G. Dr. Kavya K. , Krishnaaithal Dr. Suresh
Published: September 2020

We report a case of complete heart block patient with pacemaker in situ (VVI mode-ventricle paced sensed and inhibited) with anticipated difficult airway of a morbid obese patient presenting for incision and drainage of peritonsillar abscess on an emergency basis because of impending respiratory distress.

The challenges encountered in this case was:

Programming the pacemaker to asynchronous mode { VOO mode-ventricle paced, none sensed and no response to sensing) in this case}

Managing difficult airway.
Universal Testing of all Pregnant Women for COVID-19: A Way Forward for Comprehensive Antenatal Care
Authors: Divakar Hema , Narayanan Poorni , Singh Rita , Jyothi Girish Divakar Gubbi
Published: September 2020

The COVID-19 global pandemic has placed undue stress on health systems all around the world. However, little is known about the impact of exposure to the virus on growing foetuses or the course of COVID-19 in pregnant women, who are often asymptomatic. To develop effective policies and recommendations, robust data for both asymptomatic and symptomatic pregnant women is crucial. This can only be acquired through universal testing of all pregnant women for COVID-19. The acquired data will not only enhance our ability to answer questions around negative obstetric outcomes, such as miscarriages and preterm labours, but also lead to enhanced contact tracing, which will slow the spread of COVID-19.
Complexity Theory: Artificial Intelligence System Help Safety Improvement in the Next Pandemic
Authors: Halabi Shahad Faisal
Published: September 2020

As the coronavirus pandemic spread from Asia to the western world, drug discovery came to a near standstill. Most laboratories shut down and instruments and reagents were left untouched, except for the most essential work. The pandemic forced large and small companies, regulatory and government agencies, and academia to tap into technology, particularly artificial intelligence (AI) and machine learning (ML), for providing more than just speed and efficiency. This essay aims to dig deeply in complexity theory to help improve safety and reduce the impact of the next pandemic. It is based on implementing Artificial Intelligence (AI) to provide the safer complex theory with an example of the current situation of COVID-19. While there are no shortcuts around scientific rigor and experimentation, AI can certainly accelerate the discovery of new drugs particularly when combined with high-performance computing (HPC) and quantum computing. Evaluating new AI technologies, particularly in areas of drug discovery where there are few demonstrations of success, can be a real challenge. It is considered that safety improvement of alert systems and the risk factors, in order to organize the safety of health facilities and control the hospital environment before the potential pandemic develops. Here, we will try to apply complexity theory in our dealing with future pandemics based on the situation analysis of previous experiences.
Profile of Patients with Placental Abruption in Ultrasonography
Authors: Miyamura Namiuchi Nickolas Yugo , Fortaleza de Melo João Italo , Dutra Luiz Dias , Ramos Franco Netto Raphael Oliveira , Ramos Fernandes Victor Augusto , Manfredini Rebecca Corrêa , Mendonça Messias Villa , Rocha Fabio , Rodrigues Franco Netto Juliana de Almeida , Delgado do Amaral Kayque Wellek , Baggio Namiuchi Gabriela Kamiji
Published: September 2020

Objective: The objective of this study was to evaluate the incidence of placental abruption (PA) among nulliparous and multiparous women in the city of Dourados-MS Brazil. Materials and methods: Retrospective single-center cross-sectional study. 240 examinations of patients submitted to ultrasonography (USG) with medical indications for investigating PA were evaluated. Results: The average age was 28.6 ± 6.38, minimum 15 and maximum 43 years. The patients’ weeks of pregnancy showed an average of 7.8 ± 3.1 minimum 4 and maximum 27 weeks. PA occurred in 66 (27.7%) of the patients out of the 240 evaluated patients. Conclusion: The occurrence of PA in the studied population was high. There was no correlation between the occurrence of PA and the age of the patients. The relevance of family planning and adequate prenatal care in the early identification of risk factors for PA, as both contribute to reducing the incidence of unfavorable pregnancy outcomes.
Pengaruh Konseling Pranikah Terhadap Keharmonisan Rumah Tangga Di Kua Desa Serapung Kecamatan Kuala Kampar Kabupaten Pelalawan
Authors: Silvi Silvi , Hadi M. Fahli Zatra , Darmawati Darmawati
Published: September 2020

Konseling pranikah bantuan yang diberikan untuk menganalisis kemungkinan masalah dan tantangan yang akan muncul dalam rumah tangga mereka dan membekali mereka kecakapan untuk memecahkan masalah. keharmonisan kehidupan keluarga adalah bilamana seluruh anggota keluarga merasa bahagia yang ditandai oleh berkurangnya ketegangan, kekecewaan dan puas terhadap seluruh keadaan dan keberadaan dirinya (eksistensi dan aktualisasi diri) yang meliputi aspek fisik, mental, emosi dan sosial. Adapun rumusan dari penelitian ini Apakah terdapat Pengaruh antara Konseling Pranikah Terhadap Keharmonisan Rumah Tangga di KUA desa Serapung Kecamatan Kuala Kampar Kabupaten Pelalawan. Sampel dalam penelitian ini berjumlah 32. Penelitian ini dianalisis dengan regresi linier, pengambilan data melalui angket yang disebarkan kepada responden, dan pengolahan data menggunakan SPSS (Statistical Product and Service Solution)17.0 for windows. Berdasarkan hasil pengolahan data konseling pranikah yang diberikan berpengaruh terhadap keharmonisan keluarga di desa Serapung Kecamatan Kuala Kampar Kabupaten Pelalawan bahwa konseling pranikah berpengaruh secara siginifikan terhadap pemahaman calon pengantin hal ini dibuktikan dengan pengujian signifikansi 0,05 dan 2-tailed. Adapun t hitung didapat sebesar 6.839 dan signifikansi 0,000. Dimana t hitung lebih > dari t tabel yakni 1.699. Karena nilai t hitung > t tabel (6.839 >1.699) dan signifikansi < 0,05 maka Ho ditolak. Jadi dapat disimpulkan bahwa, Konseling Pranikah berpengaruh terhadap terhadap tingkat pemahaman calon pengantin di KUA Desa Serapung.Kata Kunci: Keharmonisan keluarga, Pasangan Suami Istri, Konseling Pranikah
Pengaruh Lingkungan Keluarga Terhadap Kepercayaan Diri Santri Pondok Pesantren Nahdlatul Ulum Kecamatan Tapung Kabupaten Kampar
Authors: Arfina Neila Rahma
Published: September 2020

Kajian ini berangkat dari pandangan bahwa kepercayaan diri salah satu aspek kepribadian yang dianggap penting dalam kehidupan manusia. Menilik gejala yang timbul, ternyata kebanyakan santri mengalami ketidakpercayaan diri. Kepercayaan diri seseorang dapat tumbuh dan berkembang melalui interaksi dengan lingkungan. Lingkungan yang dianggap memiliki peran utama dalam mengembangkan kepribadian dan menciptakan karakter seorang anak yakni keluarga. Sehingga dapat dikatakan perkembangan kepercayaan diri seseorang bermula dari lingkungan keluarga. Penelitian ini bertujuan untuk mengetahui pengaruh lingkungan keluarga terhadap kepercayaan diri santri Pondok Pesantren Nahdlatul Ulum Kecamatan Tapung. Model penelitian yang digunakan adalah deskriptif kuantitatif. Subjek penelitian 56 santri Pondok Pesantren Nahdlatul Ulum yang tingkat MTs dan MA. Untuk Menjawab permasalahan tersebut, penulis mengumpulkan data yang dibutuhkan melalui angket. Kemudian dianalisis secara Regresi Linear Sederhana dengan menggunakan bantuan perangkat koputer melalui aplikasi SPSS versi 17.0 (Statistical Product And Servise Solutions) for windows. Hasil penelitian memperlihatkan bahwa lingkungan keluarga berpengaruh signfikan terhadap kepercayaan diri, berdasarkan uji hipotesis (Uji Signifikan) ternyata nilai probabilitas α0.05 ≥  Sig (0.05 ≥ 0.006) dengan nilai pengaruh yang diperoleh melalui R Square sebesar 13,2 % dan nilai coeficient 0,364 pada rentang 0,200-0,400 yaitu berpengaruh rendah
Layanan Konsultasi Kasus Anak Korban Kekerasan Fisik Di Pusat Pelayanan Terpadu Pemberdayaan Perempuan Dan Anak (P2tp2a) Kota Pekanbaru
Authors: Rahmad Rahmad
Published: September 2020

Anak merupakan amanah dan anugrah dari Allah SWT yang perlu dilindungi. Anak dinilai rentan terhadap tindakan kekerasan dan penganiayaan, seharusnya di rawat, di asuh, di didik dengan baik agar mereka tumbuh dan berkembang secara sehat. Tindak kekerasan merupakan pelanggaran Hak Asasi Manusia (HAM) pelanggaran ketentuan hukum negara dan norma agama serta norma sosial (budaya dan peradaban) manusia. Untuk penanganan permasalahan anak korban kekerasan telah di bentuk Pusat Pelayanan Terpadu Perlindungan Perempuan dan Anak (P2TP2A). Berdasarkan laporan kasus korban kekerasan fisik yang terjadi di salah satu perguruan tinggi negeri yang saat ini dibantu dan mendapatkan dampingan oleh konselor, maka dapat disimpulkan bahwa konselor berupaya dengan sekuat pikiran dan tenaga memberikan pelayanan kepada korban dengan rincian kegiatan sebagai berikut 1) Konselor membuat perencanaan layanan konsultasi terdahulu. Rencana yang dibuat oleh konselor tersebut didasari oleh kebutuhan. 2) Konselor melaksanakan layanan konsultasi berdasarkan standar operasional prosedur dan di mulai dari tata cara penerimaan klien, melakukan interaksi malalui tatap muka langsung atau face to face dan melalui media telepon, empati, ramah dan terbuka serta memberikan penguatan psikologis, pengetahuan dan keterampilan sehingga konsulti merasa nyaman, terlindungi dan memiliki wawasan yang baru. 3) Melakukan evaluasi layanan konsultasi untuk mengetahui bagaimana proses, tepat atau tidaknya layanan yang diberikan atau perkembangan sikap dan perilaku atau tingkat ketercapaian tugas-tugas perkembangan. Secara umum aspek yang dievaluasi meliputi: kesesuaian pelaksanaan layanan, serta hambatan-hambatan yang dijumpai, dampak psikologis terhadap klien, dan respon klien, serta perubahan perkembangan klien secara pribadi dan sosialnya. 4) Setelah mengevaluasi layanan konsultasi, Selanjutnya konselor menafsirkan hasil evaluasi. Analis layanan konsultasi berkaitan dengan diri klien dalam hal ini adalah korban. Analisis hasil evaluasi yang dilakukan konselor berupa hasil konsultasi tersebut mempunyai dampak terhadap perkembangan sikap konsulti hari demi hari maupun pihak ketiga adakah perubahan positif dari tingkahlaku sebelumnya.
Examining Students’ Confidence to Learn Online, Self-Regulation Skills and Perceptions of Satisfaction and Usefulness of Online Classes
Authors: Landrum Brittany
Published: September 2020

As online class offerings continue to proliferate and more students take at least one online class in college, more research is needed to explore factors that impact students’ perceptions of their online classes. Past research has found a positive relationship between students’ computer self-efficacy and their satisfaction with online learning, but little research has explored how learning management system and online learning self-efficacy relate to perceptions of satisfaction and perceived usefulness of online classes. In addition to confidence, students must also implement and apply their learning skills in an online environment; thus self-regulation and time management as well as past online learning experience are additional factors that have been shown to be related to satisfaction with and usefulness of online learning. This study explores how students’ confidence regarding their ability to use online learning platforms, utilize self-regulation strategies, and their confidence in their ability to learn in online classes predict both their satisfaction with and perceived usefulness of online classes. Multiple regression analyses revealed that students’ confidence to learn online was the strongest positive predictor of satisfaction and usefulness of online classes. The results indicate that exploring students’ purpose and reasons for taking online classes, beyond a students’ skill set and learning strategies, are fruitful directions to pursue when assessing evaluations of online classes.
KEPUTUSAN DIVERSIFIKASI PORTOFOLIO INVESTASI DIERA MEA
Authors: FEBRIYANTO FEBRIYANTO
Published: September 2020

Manajemen keuangan, memiliki tiga fungsi dalam aplikasinya, yaitu pertama terkait dengan Keputusan Investasi, Kedua, Keputusan Keuangan, dan ketiga adalah Manajemen Aset. Berdasarkan tiga keputusan dalam fungsi manajemen keuangan tersebut, keputusan investasi adalah yang menjadi dasar kebijakan selanjutnya. Investasi merupakan alokasi dana untuk mengadakan barang modal pada saat sekarang yang bertujuan untuk menghasilkan nilai keluaran barang atau jasa dengan tujuan memperoleh manfaat nilai dan keuntungan yang lebih besar di masa yang akan datang. Diversifikasi Portofolio Investasi, merupakan kumpulan investasi dari berbagai macam aset dengan tingkat return keuntungan dan risiko yang berbeda-beda pada kurun waktu dan periode investasi tertentu. Keputusan melakukan diversifikasi portofolio investasi terutama diera MEA yang telah diberlakukan awal tahun 2016 terdiri dari berbagai aspek, yaitu Nilai return yang diharapkan, Tingkat Risiko yang ditanggung karena berbagai investor dan perusahaan se-ASEAN akan berperan dan korelasi tingkat risiko dengan return yang diharapkan dengan pertimbangan optimalisasi dan efisiensi portofolio ditengah semakin banyaknya para investor dan perusahaan. Kata Kunci: Diversifikasi, Investasi, Portofolio, Return, Risiko.