bluuebunny/crossref_metadata_2025 huggingface dataset:
ASEGURADO GARRIDO, A.; MARRODÁN GIRONÉS, J. & ANELE (2021): LA LOMLOE Y SU ANÁLISIS: UNA MIRADA TÉCNICA
Authors: González Ortega Mª Pilar
Published: November 2021

"La LOMLOE y su análisis. Una mirada técnica"nace con el objetivo de proporcionar a los distintos agentes que intervienen en el proceso educativo, un análisis, desde una perspectiva descriptiva, técnica y crítica, de las principales propuestas contenidas en la Ley Orgánica 3/2020, de 29 de diciembre, por la que se modifica la Ley Orgánica 3/2006, de 3 de mayo, de Educación (LOMLOE).La obra es el resultadode las aportaciones de inspectores de educación de diferentes comunidades autónomas, que analizan los principales bloques de la nueva Ley Orgánica y lo hacen desde un punto de vista técnico e imparcial, fruto del estudio de las diferentes teorías de la educación, de la normativa educativa, anterior y la vigente y del ejercicio de la función de supervisión que les otorga un conocimiento privilegiado del funcionamiento del sistema educativo, al conocer de primera mano el funcionamiento de las aulas, los centros escolares y el propio sistema.Como aspecto a destacar, además del análisis de los diferentes bloques, los autores subrayan los puntos fuertes y las áreas de mejora de cada uno de ellos y realizan sus propias aportaciones con el fin de contribuir a la mejora de la calidad de nuestro sistema educativo.
LA INSPECCIÓN EDUCATIVA, FACTOR CLAVE PARA LA INTERNACIONALIZACIÓN DE LA EDUCACIÓN: INTERCAMBIO DE BUENAS PRÁCTICAS EN POLONIA.
Authors: Ferrero González. Javier , Lorenzana García Luisa María , Vázquez Blanco Delia
Published: November 2021

USÍE coordina, desde el año 2019, un proyecto europeo en el marco del programa Erasmus Plus titulado “Prevención del abandono escolar temprano como medio de promover la inclusión social y laboral”, cuyo propósito principal es identificar y analizar, a nivel europeo, los factores principales que afectan a esta compleja problemática social con el objetivo de crear una Guía de resultados y buenas prácticas, con propuestas de trabajo definidas y concretas. Después del estallido mundial como consecuencia de la crisis sanitaria, se realizó un estudio comparado entre los países participantes en este proyecto (España, Polonia, Portugal, Eslovaquia y Turquía) sobre el impacto de la pandemia en el abandono escolar temprano, enlazándolo con los objetivos principales del proyecto. El programa de trabajo llevado a cabo en Polonia incluía el análisis de este impacto, junto con otros dos objetivos:

Impulsar métodos efectivos de implementar el uso de las TIC para la prevención del abandono escolar temprano.
Estudiar modos de introducir los Objetivos de Desarrollo Sostenible (ODS), en especial el nº 4, en el programa de estudios de los alumnos.

Además de un enriquecedor intercambio de experiencias, se tuvo la oportunidad de visitar centros escolares de primaria, de secundaria y de formación profesional, comprobando de primera mano las respuestas educativas llevadas a cabo en Polonia, país con una tasa de abandono escolar del 4,6%.
What’s with Caesar and the Third Person in the Gallic Wars?
Authors: BREINDEL RUTH
Published: November 2021

While we say that the Gallic Wars were written by Caesar, they were really written by the scribes. The thesis of this paper is that they used the third person singular to refer to Caesar, since they were taking down dictation and would not use “I/we,” as they were not the ones who had done the action. This use of the third person is attested to in Greek authors, and Caesar obviously was pleased with how it sounded; while he had the last word on the subject, it’s the scribes who deserve the credit for style.
‘Conserere Sapientiam’, To Engage in Wisdom:	The Rhetoric of Philosophical Debate and the Speech of Caecilius in Minucius Felix’s Octavius
Authors: DUTMER EVAN
Published: November 2021

Here I will elucidate both the rhetorical and philosophical significance of the introduction to Minucius Felix’s Octavius—in effect, to give voice to what Minucius Felix hoped to do in having Caecilius and Octavius conserere sapientiam (‘engage in wisdom’). I draw special attention to the introduction to the dialogue because (i) Minucius’ rhetorical care in establishing an appropriate otium (in other words, a locus amoenus) for his dialogue participants has been underappreciated (ii) because Caecilius’ arguments have, in general, been given short-shrift, and, (iii) because the view that the introductory parts should, instead, be read with suspicion has found a recent prominent voice in an influential recent article (Powell 2007).
Assessment of Risk Factors for Overweight and Obesity: A Cross-Sectional Study among Rural School Going Children in Hooghly District, West Bengal
Authors: Das Malay Kumar , Dasgupta Aparajita , Sinha Rabindranath
Published: November 2021

Introduction: Intermediate school children are in the transition phase from adolescent to adulthood. This age group is known for experimentation and vulnerability to adopt lifestyles predisposing to non-communicable diseases.
Method: A pre-designed and pre-tested questionnaire was used in class-room setting to collect information from students regarding presence of risk factors of non-communicable diseases. The respondents were also subjected to anthropometric measurements and blood pressure examination using standard operating procedures.
Results: A total of 761 students of class VI-XII participated in the study of which 61.4% were boys and rests were girls. Increased body mass index among boys and girls were 12.6% and 11.6% were respectively. In Bivariate analysis fast food intake (>3 times/week) (OR=1.92), less physical activity (OR=1.86), high blood pressure (OR=2.53) were significantly associated with increased body mass index. In Multivariate analysis fast food intake (AOR=1.83), less physical activity (AOR= 1.94), high blood pressure (AOR=2.40) remains significant predictor.
Conclusion: Therefore it is strongly felt that all efforts must be made to obviate the risk factors of overweight and obesity among the general mass at a very early age. Those efforts must be well structured, scientifically systematized and socially implementable.

Keywords: Children, BMI, Risk factor, Rural school.
Prevalence and Determinants of High Blood Pressure among Adolescents: A School based Study in Rural Area of Hooghly District, West Bengal
Authors: Das Malay Kumar , Sinha Rabindranath , Dasgupta Aparajita
Published: November 2021

Introduction: The World Health Organization has already warned of increasing non-communicable diseases among adolescents as a major public health problem. The importance of this age group also lies in the fact that many serious diseases in adulthood have their roots in adolescence.
Method: A pre-designed and pre-tested questionnaire was used in class-room setting to collect information from students regarding presence of risk factors of non-communicable diseases. The respondents were also subjected to anthropometric measurements and blood pressure examination using standard operating procedures.
Results: A total of 761 students of class VI-XII participated in the study of which 61.4% were boys and rests were girls. High blood pressure among boys and girls were 19.9% and 22.1% were respectively. In Bivariate analysis age > 15 years (median) (OR= 2.11), fast food intake (>3 times/week) (OR= 1.66), Alcohol consumption (OR= 2.22), less physical activity (OR=1.54), increased body mass index (OR=2.53), significantly associated with high blood pressure. In Multivariate analysis age (AOR= 2.25), fast food intake (AOR= 1.50), Alcohol consumption (OR= 2.23), less physical activity (AOR=1.71), increased body mass index (AOR=2.42) remains significant predictor.
Conclusion: Detecting the risk factors of high blood pressure prevalent in the population is of utmost importance to achieve a healthy population. Formulation and dissemination of need--based, culturally acceptable and age appropriate scientific messages for school students should be conducted more proactively.

Keywords: Adolescents, Blood pressure, Risk factor, Rural school.
Building Customer Loyalty through Service Quality and Customer Trust with Customer Satisfaction as an Intervening Variable (Empirical Study at PT. Bank Cimb Niaga Medan Pemuda)
Authors: Primadany Femmy Melany , Fauzi Amrin , Ginting Paham
Published: November 2021

The purpose of this study was to determine customer loyalty through service quality and customer trust with customer satisfaction as an intervening variable, empirical study at PT. Bank Cimb Niaga Medan Pemuda. This type of research is associative research. The research sample was 99 customers of CIMB Niaga Pemuda Medan. The data analysis technique uses path analysis and is processed using SPSS software. The results of this study indicate that service quality, customer trust, and customer satisfaction positively and significantly effect customer loyalty.

Keywords: Customer Loyalty, Service Quality, Customer Trust, Customer Satisfaction.
Determination of Academic Fraud by Using Communication Media as a Mediation Variable
Authors: Ramadiyani Eka Wahyu , . Sukirno
Published: November 2021

The main purpose of education program is to develop the talent of students to become religious, noble character, democratic and responsible. Unfortunately, many students do not fully understand these objectives. They still consider academic achievement as the key to their future success. In order to get achievements, some even commit fraud. This is what underlies the background of this research to determine academic fraud in Vocational School students in Langkat Regency in terms of Fraud Pentagon Theory by including Mass Media as a mediating variable. The research method used is quantitative with the research subjects are Vocational School students in Langkat Regency, North Sumatra. Data collection was carried out through the distribution of Likert-type questionnaires. All research questionnaires were tested before being given to actual respondents and based on the results of validity and reliability testing, it was stated that all instruments were feasible to use. The data analysis used is Path Analysis using the SmartPLS Ver. 3 for Windows. The results showed: 1). Fraudulent Behavior has a positive and significant effect on Communication Media; 2). CommunicationMedia has a positive and significant effect on Academic Fraud; 3). Fraudulent Behavior has a positive and significant effect on Academic Fraud; 4). Fraudulent behavior through CommunicationMedia has a positive and significant effect on Academic Fraud at SMK Langkat Regency, North Sumatra. The suggestion in this research is that the role of parents and closest people is needed to make students aware that the main goal of education is not just achieving achievements, moreover get the achievements by fraud mechanism.

Keywords: Fraud Pentagon Theory, Academic Fraud, Vocational High School.
The Policy of the Department of Education Bogor Regency in Improving the Quality of PAUD Education
Authors: Srihartini Yusi , Wasliman Iim , Iriantara Yosal
Published: November 2021

The level of education of PAUD teachers in Bogor Regency is still a lot of only junior high school or high school graduates, not meeting the National Education Standards, PAUD learning is still focused on learning to read and write arithmetic (calistung), assistance to institutions provided by the local government still does not meet the needs of the number of institutions existing PAUD. This study aims to determine the policy of the Bogor Regency Education Office in Improving the Quality of PAUD Education. This research approach with qualitative methods and data collection through observation, interviews, and documentation studies. The policy of the Bogor Regency Education Office in improving the quality of PAUD has been carried out to the maximum in the competence of its teachers by providing education and training as well as providing incentive assistance to honorary teachers although it is carried out in stages. The implementation of PAUD policies always synergizes and partners with organizations/institutions whose members are managers and educators. Obstacles in implementing policies in Bogor Regency are still constrained in human resources, namely the number of inspectors as PAUD supervisors is not balanced with existing PAUD institutions. The results of policy implementation in improving quality with the spread of Holistic Integrative PAUD in Bogor Regency.

Keywords: Policy, Quality, PAUD Education.
Late Onset Alzheimer Dementia in Patient with Genotype E3/E4: A Case Report
Authors: Kaban Irfan Kurnia , Haryono Yudha
Published: November 2021

ackground: Alzheimer's dementia (AD) is a neurodegenerative disorder and there is progressive cognitive impairment, functional deficits and behavioral changes. This neurodegenerative disease process is classically characterized by two pathological features: amyloid- β plaque deposition and neurofibrillary tangle of tau hyperphosphorylation. The most established genetic risk factor for late-onset Alzheimer Disease is the APOE gene allele 4. We will report a case of late-onset Alzheimer's Dementia with genotype E3/E4.
Case: A 70-years-old woman patient, complained by her family that she often forgets. The Mini Mental State Examination showed disturbances in orientation, attention, calculation and recall. Non-contrast Brain Magnetic resonance imaging examination revealed decrease in hippocampal volume. Patient also performed a molecular examination of the Apolipoprotein E (APOE) genotype and the genotype E3/E4 was detected
Conclusion: The APOE E4 gene has a major role in the occurrence of Late-Onset Alzheimer's Dementia.

Keywords: Alzheimer Dementia, Apolipoprotein E.
Effectiveness of Beet Root Juice on Reduction of Blood Pressure among People with Hypertension at Sothupakkam, Kanchipuram District
Authors: D Vaishnavi.
Published: November 2021

Aim: Effectiveness of beet root juice on reduction of blood pressure among people with hypertension at Sothupakkam, Kanchipuram district
Objectives: (i) to assess the level of blood pressure among people with hypertension residing at Sothupakkam. (ii) to evaluate the effectiveness of beetroot juice on reduction of blood pressure among people with hypertension (iii) to find out the association between effectiveness of beetroot juice on reduction of blood pressure with the selected demographic variables.
Methodology: Researcher adopted the quantitative research approach, one group pre test and post test design, study samples with the age group 25-65 years old for 60 samples at Sothupakkam Kanchipuram district using purposive sampling technique
Results: The findings of the study was pre and post systolic mean difference 30.66 with the standard deviation 10.39 and applying paired ‘t’ test value 22.8 and pre and post diastolic mean difference 17.33 with standard deviation 10.22 and applying the paired ‘t’ test value 13.1 since the calculated value was greater than the table value at 0.05 level of significance. Hence it was significant improvement in reduction of blood pressure among people with hypertension. It has shown that the consumption of beet root juice was effective
Conclusion: The present study was conducted in sothupakkam village with the sample size 60 people with hypertension and they had been administered with the beet root juice on reduction of blood pressure which showed the remarkable changes in the health status of the susceptible of people with hypertension and they had give the feedback regarding the effectiveness of the natural home remedy.

Keywords: Beet root juice, hypertension, high blood pressure.
Meta-Analysis: The Effect of Anemia,
Pre-Eclampsia and Parity on the Prevalence of
Low-Birth-Weight Infants in Indonesia
Authors: Rahmah Afiatun , Panghiyangani Roselina , Muhyi Ruslan
Published: November 2021

The incidence of LBW in Indonesia varies greatly from one region to another. Nationally based on the Indonesian health demographic survey, the incidence of LBW has increased to 6.2% in 2018. This study aims to determine the magnitude of anemia, pre-eclampsia and parity on the incidence of LBW. LBW in Indonesia. This study is a meta-analysis using PRISMA, obtained 22 journals containing case-control and cross-sectional journals from 1219 from two databases, namely PubMed and scholar, data presentation using forest plots obtained using the Rev.Man 5.3 application. The magnitude of the combined odds ratio (OR) shows that the effect of anemia on LBW is 3.25, anemia tends to have a large effect on the incidence of LBW with a value of 3.65, then the effect of pre-eclampsia on LBW is 2.70, pre-eclampsia tends to have a similar effect. large in the incidence of LBW with a value of 5.50 while the effect of parity on LBW is 1.45 parity tends to have a large effect on the incidence of LBW with a value of 1.30. In the three variables analyzed by meta-analysis, the greatest influence on the incidence of LBW is pre-eclampsia. There is an influence of anemia, pre-eclampsia and parity on the incidence of LBW, early detection of anemia should be carried out early and need to be evaluated after giving Fe. In pre-eclampsia, it is necessary to have an early examination during pregnancy visits, while at parity, it must be socialized and evaluated again for the family planning program. so that the incidence of LBW can be reduced.

Keywords: anemia, pre-eclampsia, parity, LBW, meta-analysis
Calcaneal metastases, urothelial origin
Authors:   Hematology Oncology Fellow, Franciscan Health Olympia Fields, South Crawford Avenue, Olympia Fields Illinois 60461, USA, Qaiser Meshal , Kanwardeep Arora ,   Hematology Oncology Fellow, Franciscan Health Olympia Fields, South Crawford Avenue, Olympia Fields Illinois 60461, USA
Published: November 2021

Our patient is a 78-year-old lady with known metastatic papillary urothelial carcinoma that presented for evaluation of left foot pain. Imaging studies revealed an aggressive appearing mass measuring approximately 4.8 cm that was subsequently biopsied with pathology consistent with her known diagnosis of urothelial carcinoma.
Why primary malignancies of the heart and pericardium are so rare
Authors:   Department of Medicine, St George’s University, London, Shaw Naomi , Stephens Shiby ,   School of Biosciences, Cardiff University, UK
Published: November 2021

Primary Malignant Cardiac Tumours (PMCTs) of the heart and pericardium are extremely rare. The incidence rate of both malignant and benign primary tumours is 0.02%, however only one quarter of these are malignant. The reason why these specific malignancies are so uncommon is not yet well understood. This review aims to determine why the heart and pericardium are such inhospitable hosts to PMCTs.
Hemophagocytosis or emperipolesis by lymphoblast after rapid transformation of chronic myeloid leukemia
Authors:   Center of Pediatric Oncohematology, University Hospital Oswaldo Cruz, Brazil., Cruz-Souza João Lucas , Paula de Carvalho Fernanda ,   Center of Pediatric Oncohematology, University Hospital Oswaldo Cruz, Brazil., Wanderley de Melo Márcio Antonio ,   Marcelo Magalhães Laboratory, Brazil, Leite Edinalva Pereira ,   Center of Pediatric Oncohematology, University Hospital Oswaldo Cruz, Brazil., Marques-Salles Terezinha de Jesus ,   Center of Pediatric Oncohematology, University Hospital Oswaldo Cruz, Brazil
Published: November 2021

A Male, 11-Years-Old, Admitted In March 2019 With Chronic myelogenous leukemia (CML) in treatment with Imatinib. Three months after diagnosis in outpatient visit was observed increase of splenomegaly and appearing of inguinal and cervical adenomegalies. Bone marrow apiration revealed 70% of blasts, some of them with hemophagocytosis (Figure 1). The immunophenotyping showed blasts positive for CD10, CD19, CD20, CD22, CD79a, CD45, HLA-DR, indicating transformation to B precursors ALL. Bone marrow karyotype was 46,XY,t(9;22), FISH (BCR-ABLES probe) confirmed rearrangement with p210. The patient was treated with higher dose of Imatinib (600 mg/m²), but evolved with bone marrow aplasia and infectious process, being then reajusted to 400 mg/m² with clinical and hematologic improvement. After 30 days had disease aggravation and resistance to Imatinib. The patient initiated EsPh-ALL 2009 protocol, but in D33 with no remission of disease continued with protocol. In September, during consolidation phase evolved with Central Nervous System infiltration and disease persistence, dying for disease in progress. This patient had no clinical findings of Hemophagocytic Lymphohistiocytosis (HLH) and bone marrow cytology showed the several hematopoietic cells inside blast cells.
A novel FSHR-ALK and EML4-ALK double fusion variant in advanced lung adenocarcinoma: A case report
Authors:   Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China, Zhu Yili , Wu Ying ,   Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China, Huang Bo ,   Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China, Fan Jun ,   Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China, Nie Xiu ,   Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Published: November 2021

Anaplastic Lymphoma Kinase (ALK) gene fusions are detected in approximately 5% of lung adenocarcinomas, and data on double ALK fusions remain scarce because of their low occurrence rate. To date, there have been only a small number of case reports on double ALK fusions. In this report, we describe a novel double ALK fusion, FollicleStimulating Hormone Receptor (FSHR)-ALK and echinoderm microtubule-associated protein-like 4 (EML4)-ALK, which was observed in a patient with advanced lung adenocarcinoma who was sensitive to alectinib. Alectinib treatment was administered orally 300 mg twice daily. After a month, imaging re-examination revealed a significant decrease in tumour size and markedly relieved atelectasis. According to the Response Evaluation Criteria in Solid Tumours, the patient was considered to have a partial response to alectinib. To the best of our knowledge, this report is the first to describe this novel double ALK fusion in a patient, and these findings may provide a reference for other patients with such gene alterations.
Two cases of severe esophageal ulcer caused by chemotherapy for breast cancer after particle beam therapy for esophageal cancer
Authors:   Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, 260-8677 Japan, Uesato Masaya , Sakata Haruhito ,   Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, 260-8677 Japan, Matsubara Hisahiro ,   Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, 260-8677 Japan
Published: November 2021

Background: Particle beam treatment for esophageal cancer can produce a better local therapeutic effect than can conventional radiotherapy. However, events that occur in the esophagus during or after the treatment of other cancers after that are unknown. Case summary: The first patient, a 64-year-old woman, had undergone heavy ion radiotherapy for esophageal cancer. Endoscopic submucosal dissection was performed for local residual tumor. Five years later, cancer was found in the right breast, and the patient underwent partial mastectomy and adjuvant chemotherapy. Six years after heavy ion radiotherapy, oral intake became difficult. A benign esophageal ulcer with circumferential stenosis was observed at the site of heavy particle irradiation. The second patient, a 63-year-old woman, had undergone proton therapy for esophageal cancer and photodynamic therapy for local residual tumor. Four years later, cancer was found in the left breast, and the patient underwent preoperative adjuvant chemotherapy, which reduced the size of the breast cancer. Oral intake became difficult 5 years after proton therapy. Endoscopy showed a benign esophageal ulcer with severe stenosis at the site of proton irradiation. Conclusion: After particle beam therapy for esophageal cancer, patients who undergo chemotherapy for other cancers may develop an esophageal ulcer. Keywords: Particle beam therapy; esophageal cancer; esophageal ulcer; breast cancer; chemotherapy
A rare cause of familial atrioventricular block with a novel LMNA mutation (p. Ala502Val)
Authors:   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Mariem Drissa , Wael Yaakoubi ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Sana Helali ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Drissa Hbiba ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia.
Published: November 2021

Mutation in LMNA accounts for 10% of Dilated Cardiomyopathy (DCM). It is characterised by progressive conduction system disease, arrhythmia and systolic impairment, lamin A/C heart disease is the most malignant gene common in DCMs especially in man. It is likely to be an under-recognised cause of this cardiomyopathy. In certain clinical scenarios, particularly familial DCM with early conduction disease, the probability of finding an LMNA mutation may be quite high.
Neutrality on assisted dying: A personal view
Authors:   University of Milan, Italy
Published: November 2021

Medical bodies should take a neutral stance on the issue of assisted dying and should not be publicly opposed to or support any change in legislation that may allow assisted dying for terminally ill, mentally competent adults [1]. At the heart of the case of neutrality is the principle that the decriminalization of assisted dying should be a matter for society as a whole to decide, using parliamentary processes. No particular group within it should have a disproportionate influence on this decision. On the other hand, individual healthcare professionals, as responsible citizens, are entitled, perhaps obliged, to express their views about the ethical and clinical case for a law allowing assisted dying for the terminally ill.
Therapeutic approaches towards COVID-19: A critical insight
Authors:   Department of Biochemistry and Molecular Biology, Jahangirnagar University, Bangladesh, Azizur Rahman Mohammad , Rahman Nabidur ,   Department of Biochemistry and Molecular Biology, Jahangirnagar University, Bangladesh, Shakil Salman ,   Department of Pharmacology and Toxicology, University of Otago, University of Otago, 362 Leith St, North Dunedin, Dunedin 9016, New Zealand, Habiba Umme ,   Healthcare Pharmaceuticals Limited, Bangladesh
Published: November 2021

oronavirus disease 2019 (COVID-19) has been taking a heavy toll worldwide. Since its outcome, different therapeutic strategies have been formulated against COVID-19. Unfortunately, none of them alone or in combination has come out successful against this pandemic. Current review discusses the measures applied so far against COVID-19 and suggests future aspects for the betterment of the humankind. Keywords: Anti-viral drugs; COVID-19; Plasma therapy; SARSCoV-2; Vaccination.
An unruptured “Pocket – Like” giant apical pseudoaneurysm of the left ventricle: A case report
Authors:   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Bassem Rekik , Wael Yaakoubi ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Fourat Zouari ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Fathia Mghaith ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Farhati Abdejlil ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Noureddine Elarbi ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Sana Ouali ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Manel Ben Hlima ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Sami Mourali Mohamed ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia., Selim Boudiche ,   Hopital La Rabta Adult Cardiology Service Tunis Ministry of Public Health, Tunisia.
Published: November 2021

Cardiac pseudoaneurysm is rare and appears mostly as tardive complication of Acute Myocardial Infarct (AMI). Its apical localization is also scarce as it is usually described in posterior or lateral wall of left ventricle. Its diagnosis is based on cardiac imaging. We report a case of a hypertensive, diabetic and smoking 64-year-old man with a past history of anterior AMI. He was symptomatic of chest discomfort. Physical examination indicates an apical murmur, his electrocardiogram showed a regular sinus rhythm and a complete left branch block. The Transthoracic (TTE) echocardiography revealed a giant apical pocketlike aneurysm lined with a clot. Cardiac Magnetic Resonance Imaging (CMRI) confirmed the diagnosis of an apical pseudoaneurysm due to ischemic heart disease in the stage of severe heart failure.
Radiosurgery and re-irradiation of brain metastases with cyberknife
Authors:   Department of Clinical Oncology, Medical University –Plovdiv, Bulgaria, V Popov , V Graklanov ,   First Department of Internal Diseases, Medical University-Plovdiv, Bulgaria, A Botushanova ,   UMHAT ”Sv. Georgi”, Plovdiv, Bulgaria
Published: November 2021

Lung cancer is a leading cause of cancer incidence and mortality worldwide with more than 2 million newly diagnosed cases in 2018. The disease is usually diagnosed in stage 3 or 4 with extensive clinical symptoms, which is a bad prognostic factor. Around 40% of patients with brain metastases are with a primary lung cancer, which shows the importance of this pathology. The main treatment option for inoperable lesions is radiosurgery, which can be done more than once in case of progression. This gives an opportunity to deliver a high dose in low volume with a high dose gradient while maintaining healthy tissues. Re-irradiation gives a change for good quality of life for patients with a long life expectancy. This case confirms that two and even three times re-irradiation with CyberKnife is an effective and safe therapeutic option for patients with brain metastases. Keywords: CyberKnife; radiosurgery; re-irradiation; brain metastases; lung cancer.
Right ovarian torsion and oophorectomy in second trimester of pregnancy with subsequent live birth at term
Authors:   Department of Obstetrics, Gynaecology, and Perinatology, Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun state, Nigeria, Ijarotimi Omotade A , Omitinde Olumide A Adeniyi ,   Department of Obstetrics, Gynaecology, and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria, Omitinde Stephen O ,   Department of Obstetrics, Gynaecology, and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria, Ubom Akaninyene E ,   Department of Obstetrics, Gynaecology, and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria, Ibrahim Momoh ,   Department of Obstetrics, Gynaecology, and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria, Adeyemi Adebanjo B ,   Department of Obstetrics, Gynaecology, and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria
Published: November 2021

Introduction: Ovarian torsion is a cause of acute abdomen in pregnancy with an incidence of less than 1% occurring most commonly in the first trimester. The symptoms are non-specific with a propensity for missed or delayed diagnosis which may worsen the morbidity associated with this condition. Management is mainly surgical and pregnancy outcome is usually satisfactory. Case presentation: We present the case of a 29-year-old G2 P0 +1 with background polycystic ovaries who complained of abdominal pains at an Estimated Gestational Age (EGA) of 21 weeks in pregnancy. Clinical suspicion was confirmed with a 2D abdominopelvic ultrasound and she subsequently had emergency exploratory laparotomy with right oophorectomy. Pregnancy progressed well and she had a live birth at term. Conclusion: Ovarian torsion is rare in pregnancy. Complications following prompt surgical intervention are however, few and pregnancy outcomes are usually favourable. Keywords: Ovarian cyst; torsion; acute abdomen; cyst accident; pregnancy.
Children are victims of industrialization and commercialization of early feeding practices: A review of obesity in preschool children in Egypt
Authors:   Regional Advisor Nutrition, Eastern Mediterranean Office- World Health Organization., Al-Jawaldeh Ayoub , Abul-Fad Azza ,   Professor of Pediatrics, Faculty of Medicine, Benha University, Egypt.
Published: November 2021

Introduction: Obesity Is Global Problem Which Begins From Early Childhood. Early Exclusive Breastfeeding (EBF) without foods or Milk Formula (MF) before 6 months, with continued breastfeeding for two years are optimal feeding practices. Aim: To review studies conducted to assess the nutritional status of preschool children with a focus on obesity and stunting and their association with EBF vs MF feeding. Methods: We used online search engines of the Egyptian university libraries consortium (www.eulc.edu) to search for studies on overweight, obesity stunting and wasting in preschool children. We identified 919 theses that were filtered to 32 studies then to 18 theses fitting the criteria of the study. Analysis of the pooled data was done for the studies with children who were EBF (2 studies) vs children who were exposed to MF (16 studies) by age and sex. Findings: Pooled analysis for children aged 6-59 months among MF vs. EBF studies as follows: overweight 5.4% vs. 3.45%, obesity 13.8% vs. 5.65%, stunting 21.6% vs. 1.15% and wasting 9.7% vs. 0.85% respectively. Obesity and overweight were higher in males in both studies, whereas stunting and wasting were higher in females in both studies (ages 0-72 months). Early and extended MF feeding, foods before 6 months of life, chips and canned drinks were prominent risk factors for obesity. Large family size was associated with obesity and short birth interval with stunting. Colostrum feeding, longer duration of breastfeeding, fruits and vegetables were protective. Obese children showed clinical signs of anemia, vitamin A and D deficiency, severe asthma and developmental delay. Conclusions: Obesity and MF feeding beyond 6 months and well into 5 years of age threaten child health. Policies and legislations are needed to control, counter and monitor marketing tactics supported by guiding messages. Keywords: Obesity; overweight; stunting; wasting; fast foods; breastfeeding; birth spacing; child development; infancy; preschool children; anthropometry; growth.
Mycobacterium bovis meningitis together with systemic brucellosis
Authors:   Department of Infection Disease and Clinical Microbiology, Faculty of Medicine, Marmara University, İstanbul, Turkey., Başarı Tuğçe , Tigen Elif Tükenmez ,   Department of Infection Disease and Clinical Microbiology, Faculty of Medicine, Marmara University, İstanbul, Turkey.
Published: November 2021

M. bovis and Brucella spp. are zoonotic bacteria that can infect humans. These pathogens are usually seen in people who are primarily engaged in animal husbandry and consume infected animal products separately. Although our country is endemic for tuberculosis and brucellosis, it is rare to detect these two pathogens concomitantly. Thus, the case is instructive and unusual in terms of the coexistence of two concomitant zoonotic pathogens. Keywords: M. bovis; meningitis; brucellosis; concomitant.
A masked ST-elevation myocardial infarction
Authors:   Cremona Hospital, Cremona, Italy., Besana Michele , Regazzoni Valentina ,   Cremona Hospital, Cremona, Italy., Enrico Passamonti ,   Cremona Hospital, Cremona, Italy., Giuli Valeria De ,   Cremona Hospital, Cremona, Italy., Danzi Gian Battista ,   Cremona Hospital, Cremona, Italy., Loffi Marco ,   Cremona Hospital, Cremona, Italy.
Published: November 2021

Acute cardio-cerebral infarction is a rare circumstance characterized by high morbidity and mortality. It represents a management challenge due to the difficulty to choose which condition needs to be treated first. We describe the therapeutic challenge of a patient presenting with ischemic stroke and ST-elevation myocardial infarction. Keywords: Ischemic stroke; STEMI; cardio-cerebral infarction; myocardial infarction; haemodynamic stroke.
Tildrakizumab and omalizumab: An interlocking therapy for autoimmune conditions
Authors:   Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81 00133 Rome, Italy., Diluvio Laura , Pensa Chiara ,   Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81 00133 Rome, Italy., Piccolo Arianna ,   Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81 00133 Rome, Italy., Lanna Caterina ,   Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81 00133 Rome, Italy., Bianchi Luca ,   Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81 00133 Rome, Italy., Campione Elena ,   Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81 00133 Rome, Italy.
Published: November 2021

In Western countries the number of individuals suffering from an autoimmune condition is constantly growing and often patients suffering from autoimmune disease are susceptible to developing a second autoimmune disorder. We report a case of an adult female patient affected by psoriasis vulgaris and treated with tildrakizumab, a humanized monoclonal antibody targeting interleukin-23, who later developed chronic spontaneous urticaria and started omalizumab, a humanized antibody to IgE, showing a favorable outcome. We speculate that the two combined therapies have restored the cytokine balance bringing it towards tolerance and remission of the two pathologies. It is conceivable that tildrakizumab may have a synergic action with omalizumab in the treatment of urticaria in patients affected by both psoriasis and urticaria. Our case and the study of the mechanisms of action of the two drugs suggest how the two therapies can act with an interlocking mechanism in achieving the final therapeutic effect. Keywords: Chronic spontaneous urticarial; dual biologic therapy; omalizumab; psoriasis; tildrakizumab.
Clinical outcomes of patients with advanced solid tumors of cutaneous capillary hyperplasia following treatment with camrelizumab: A retrospective case-control study
Authors:   Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China., Wang Xiaolei , Long Qihe ,   Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China., He Qian ,   Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China., Li Jingjing ,   Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China., Su Yu ,   Department of Ophthalmology, Anhui Provincial Children’s Hospital, Hefei 230000, Anhui Province, China., zhao Jun yang ,   Department of Pediatric Oncology Center, Beijing Children Hospital, Capital meidical university, National Ccenter for Children’s Health, China., Li Fanfan ,   Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China.
Published: November 2021

Objective: To investigate the difference of clinical outcomes between patients with and without Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP) after camrelizumab treatment. Methods: A retrospective, matched case-control study was designed. A total of 92 patients with advanced solid tumors treated with camrelizumab at xx hospital between July 2019 and October 2020 were included, of whom 16 patients developed RCCEP (RCCEP group) and the remaining 76 served as the control group. The primary endpoint is Progression-Free Survival (PFS), and the secondary endpoint is Objective Response Rate (ORR) and Overall Survival (OS). Multivariate Cox regression analysis is used to assess the relevant indicators of PFS. Results: Compared with the control group, significantly increased ORR was observed in patients with RCCEP (56.3% vs 19.7%) (P < 0.05). The PFS was 13 months (5-15 months) in the RCCEP group and 6 months (2-11 months) in the control group. Compared with the control group, the PFS was significantly higher in the RCCEP group (HR = 0.555, 95% CI: 0.278-0.985, P < 0.05). In multivariate Cox regression, RCCEP remained statistically significant after excluding potential confounders (HR=0.312, 95% CI: 0.095-0.637, P < 0.01) and was associated with PFS in patients. Conclusion: In camrelizumab treatment, the occurrence of RCCEP may be a marker of strong immune response and improved tumor treatment outcomes, and has potential predictive value in patient efficacy and prognosis.
Middle Eastern Immigrants' Satisfaction With Malaysian Healthcare
Authors: Khalid Haliyana , Anis Mohamad Saleem , Mohd Rizal Adriana
Published: November 2021

There has been an increasing number of Middle Eastern immigrants arriving in Malaysia over the last decade due to political and economic instability in their countries. Given their somewhat ambiguous living conditions and residence status here (e.g. legal, illegal, refugee, etc.), it is imperative to understand their situation in-depth. One of the most important aspects that impact the living conditions of these immigrants is health; accordingly, in this research, we attempted to discover the extent and factors of Middle Eastern immigrants’ satisfaction with the Malaysian healthcare system and its facilities. In this cross-sectional study, we used a questionnaire to collect data from 219 respondents both online and in-person. Various statistical methods were employed to analyze the data, including descriptive analysis, Pearson’s correlation, and multiple regression. The findings indicate a slight dissatisfaction among Middle Eastern immigrants with respect to the Malaysian healthcare system, due to the cost of health services and communication barriers. The results also highlight that marital status, monthly income, awareness of services, Malay language proficiency, and culture are factors that impact immigrants’ perception of the quality of healthcare services. Therefore, this study provides valuable insights into this important group of immigrants in terms of their experience in public and private healthcare facilities that shape their opinions and satisfaction with the Malaysian healthcare system.
Developing a Taxonomy of Informal Learning Space
Authors: Chin David C.W. , Hsu Cathy H.C. , Yau Oscar K.T.
Published: November 2021

The move from traditional teaching-centred approach to student-centred approach has resulted in more student collaboration outside classroom, contributing to the growing importance of information learning space (ILS). Review of recent literature suggests the ILS research agenda is at an initial stage of development, without convergence in research methods and lacks theoretical underpinning. Research studies were conducted on a piece meal basis, lacking comparability and generalization. Using a mixed-method approach, this study contributes to ILS knowledge by introducing a qualitative methodology based on concept mapping and sorting for idea generation; to develop a taxonomy of four user-generated ILS types from a portfolio of 38 ILS sites on campus. This is followed by quantitative validation using seven ILS sites to evaluate satisfaction and usage behaviour. Drawing from middle range theory and the ILS taxonomy, practical design principles are proposed based on functionalities and features for the four ILS types. The learnings can be shared with designers, policy makers and different institutions to facilitate knowledge transfer, which contributes to generalization of learnings and theory building.
Adopting a New Marking and Reporting System (MaRS) at Faculty Level: A Survey of Lecturers’ Level of Readiness and Acceptance
Authors: Amir Johan Syafiqah Johan , Khairuddin Zulaikha , Sabri Salina , Mohd Yusof Fairuz Husna , Shamshul Bahrn Fatin Fatinah , Ismail Othman
Published: November 2021

At the end of each semester, academic and administrative staff of a faculty have to analyse students’ results for a myriad of factors such as calculating performance of students and lecturers, and for the university’s senate confirmation. Unfortunately, many relevant personnel at the faculty level lack the clearance to access students’ results directly. To circumvent this issue, individual lecturers were required to print out and submit hardcopies of students’ results and channel the data to relevant personnel. When the Covid-19 pandemic hit and lecturers were unable to submit the hardcopies, the faculty had to find an alternative. The introduction of the Marking and Reporting System (MaRS) marks a change from manual hardcopy submission of results following travel restrictions necessitated by the Malaysian government during the Covid-19 pandemic. As with any technological shift and innovation, the level of readiness and acceptance of academic and administrative staff at a faculty must be examined. This paper uses the Technology Acceptance Model (TAM) (Davis, 1986; Davis, Bagozzi & Warshaw, 1989) to determine the level of readiness and investigate the level of acceptance among academic and administrative staff in using MaRS via a questionnaire. The findings suggest that with adequate guidance and assistance, the respondents were positive towards using MaRS as the system offers advantages to them such as being cost effective, environmentally friendly, and more convenient in recording students' results. In short, the respondents are ready and willing to use MaRS to manage students’ results despite facing some difficulties in handling the system, because positively overcoming challenges will yield positive outcomes.
Certain Kinds of Bipolar Interval Valued Neutrosophic Graphs
Authors:   PG and Research Department of Mathematics, Islamiah College (Autonomous), Vaniyambadi, Thiruvalluvar University, Serkkadu, Vellore 632 115, Tamil Nadu, India, Jagadeeswari L. ,   PG and Research Department of Mathematics, Islamiah College (Autonomous), Vaniyambadi, Thiruvalluvar University, Serkkadu, Vellore 632 115, Tamil Nadu, India,   CMS Business School, Jain University, Bengaluru, India,   Laboratory of Information Processing, Faculty of Science Ben M’Sik, University Hassan II,B.P.7955, Sidi Othman, Casablanca, Morocco, Sudhakar V.J. , V.Navaneethakumar V , Broumi Said
Published: November 2021

Neutrosophic theory has several application in the field of graph theory. In this paper we initiated Certain Kinds of Bipolar interval valued nentrosphic graphs. Such as, sub divsicon BIVNG, Total BIVNG, BIVNLG and also investigate the isomorphism, Coweak isomorphism of BIVNG with properties .
A Novel Approach to Necessary and Sufficient Conditions for the Diagonalization of Refined Neutrosophic Matrices
Authors:   Department of Mathematics, Gaziantep University, Gaziantep27310, Turkey, Olgun Necati ,   Department of Mathematics,Gaziantep University, Turkey,   Department of Mathematics, Gaziantep University, Gaziantep 27310, Turkey,   Tishreen University, Faculty of Science, Department of Mathematics, Lattakia, Syria, Hatip Ahmed , Bal Mikail , Abobala Mohammad
Published: November 2021

This work is dedicated to study the conditions of diagonalization in the case of refined neutrosophic matrices, where it presents the necessary and sufficient conditions for the diagonalization of these matrices by finding a relationship with classical diagonalization of matrices. Also, it describes an algorithm to obtain all eigen values and eigen vectors of refined neutrosophic matrices from the classical ones.